SGTCid condition conc unit SCO2|YBR024W.score SCO2|YBR024W.strain.pval SCO2|YBR024W.strain.significant SCO2|YBR024W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1783 st039459 87.517 µM 7.62222203775537 3.4083028636871e-15 yes 1 1.24672821312717e-14 3 729761 SGTC_1784 st039334 36.3 µM 7.08710215061944 2.2228224532464e-13 yes 2 6.84746497475627e-13 3 3496984 SGTC_451 chloral hydrate 100 µM 5.8880965248057 8.90843212061337e-10 yes 3 1.953344697774e-09 16 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1663 st014140 55.4 µM 4.77799674111168 5.23298583046161e-07 yes 4 8.85251249282967e-07 10 4207120 SGTC_520 3584-0023 682 µM 4.66809034695147 9.19269435711212e-07 yes 5 1.5200610885094e-06 13 1340790 SGTC_975 1335-0046 28.5 µM 4.480745567849 2.33548309271704e-06 yes 6 3.71913708221587e-06 22 16486740 SGTC_2895 9054447 58.44 µM 4.34663817124025 4.45493482591617e-06 yes 7 6.91199907677952e-06 6 2697450 SGTC_1195 1502-0147 41.1 µM 4.22099859860622 8.02594472876959e-06 yes 8 1.21611224517091e-05 17 817940 SGTC_1563 conessine 56.1 µM 4.05157794604828 1.73135261545896e-05 yes 9 2.54366861301241e-05 14 441082 An anti-amoebic, histamine inhibitor. SGTC_2088 5278280 127.392 µM 3.95328405631364 2.66931705058101e-05 yes 10 3.85429167554957e-05 22 791502 SGTC_2049 5262831 67.185 µM 3.85721262200956 4.03764125545109e-05 yes 11 5.73436972853034e-05 29 763417 SGTC_47 0149-0135 24.25 µM 3.84239246765113 4.30029341021914e-05 yes 12 6.09204003436388e-05 21 5239155 SGTC_1807 st050092 58.9 µM 3.71269673621893 7.39580072258697e-05 yes 13 0.000102531273188419 18 5008496 SGTC_2149 5554786 194.827 µM 3.6643612267368 9.01354050395219e-05 yes 14 0.000123978317214352 47 745063 YPR165W RHO1 SGTC_3232 9132874 49.47 µM 3.65240511388745 9.46217441988935e-05 yes 15 0.000129897802362749 22 3784940 SGTC_1423 4048-0112 5.59 µM 3.64371876225725 9.80118872492378e-05 yes 16 0.000134363522582797 31 X1423 SGTC_674 0498-0004 451 µM 3.63253127490703 0.000102546478339241 yes 17 0.000140327273803037 30 4231473 SGTC_1324 1418-0026 34.4 µM 3.48502900955344 0.000184022697333943 yes 18 0.000246041844365468 26 1372513 SGTC_1711 st032263 62.8 µM 3.40253292638958 0.000252836955726434 yes 19 0.00033382154951231 28 3958979 SGTC_2907 7721985 69.9 µM 3.34266582738424 0.000317061846075792 yes 20 0.000414888800023294 51 3267881 SGTC_2475 5812728 15.03 µM 3.33914878997065 0.00032127098557021 yes 21 0.000420177699320429 41 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2471 5466956 24.79 µM 3.31198136975438 0.000355579061622186 yes 22 0.000463188574226385 26 724419 SGTC_1656 st012921 11 µM 3.30672481211007 0.000362598356172628 yes 23 0.000471967865074496 50 6732821 SGTC_208 k072-0098 12.366 µM 3.27864106915855 0.000402330863192706 yes 24 0.000521541073121013 79 5948901 SGTC_2310 7668677 200 µM 3.26974962888006 0.000415729115972888 yes 25 0.000538213565871325 64 2197143 SGTC_1456 k015-0012 13 µM 3.26670388971181 0.000420413020631959 yes 26 0.000544037121643578 55 2989616 SGTC_2425 5628681 7.85 µM 3.25308130535853 0.000441967763562111 yes 27 0.000570804136426466 56 5714958 SGTC_105 0111-0055 734.78 µM 3.22407221921414 0.000491324223213767 yes 28 0.000631907613932265 24 5179370 SGTC_284 0988-0104 32.6 µM 3.21351315379661 0.000510522437929718 yes 29 0.000655608959547493 27 4666532 SGTC_2066 5222451 176 µM 3.19674738675513 0.000542436886400137 yes 30 0.000694932937285439 64 2281147 SGTC_1608 st001473 40.5 µM 3.16840401694907 0.000600616641196112 yes 31 0.000766391759061165 67 7292267 SGTC_1525 8-methoxypsoralen 92.5 µM 3.16152795462252 0.000615574345433248 yes 32 0.000784718767000086 71 4114 Related to psoralen; DNA damaging agent. SGTC_1519 esterone 74 µM 3.14281143977611 0.000658049044453855 yes 33 0.000836667979303014 52 698 A steroid. SGTC_2111 5486399 200 µM 3.10474955835324 0.000752886208480273 yes 34 0.000952200990172728 98 689674 SGTC_748 act1.228 77.9 µM 3.02483993909275 0.000994242083693248 yes 35 0.00124382369969928 133 4421505 YNR035C ARC35 SGTC_2323 6148992 148.28 µM 3.02122582280209 0.00100667698502256 no 36 0.00125876762144619 68 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_350 k064-0020 19.8 µM 2.98956589589907 0.00112186664227897 no 37 0.00139687089794647 66 2790705 SGTC_774 k060-0086 136 µM 2.97470961382437 0.00117997808929057 no 38 0.00146633008528647 61 5911235 SGTC_3002 9075603 71.4286 µM 2.96330982726659 0.0012264239553263 no 39 0.00152175029556753 72 20105405 SGTC_2794 7785382 27.27 µM 2.95133448092699 0.00127701157396178 no 40 0.00158202038383131 100 2205081 SGTC_2838 9002687 71.43 µM 2.94226132628804 0.00131660224448626 no 41 0.00162912420716619 74 6457060 SGTC_417 st075190 100 µM 2.93421563286954 0.00135264483615747 no 42 0.00167195903995957 55 222757 SGTC_1121 fusaric acid 630.51 nM 2.93205768956097 0.00136246401037546 no 43 0.00168362095584996 82 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_912 3474-0017 2.18 µM 2.86044351462144 0.00172766856056987 no 44 0.00211524454078454 79 3360550 SGTC_449 xestospongin c 11.1929 µM 2.8324752444514 0.00189301390964926 no 45 0.0023094571279126 142 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1698 5-fluorocytosine 1.055 µM 2.82040310424301 0.00196872702932609 no 46 0.00239816781039602 43 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_584 0986-0246 15.4 µM 2.81670067721029 0.00199249269712541 no 47 0.00242598604957423 67 53315 YDR232W HEM1 SGTC_3175 9106517 49.47 µM 2.8165557797101 0.00199342806047474 no 48 0.00242708065152443 59 41468073 SGTC_1911 st060208 74.3 µM 2.78903898926675 0.00217845813683283 no 49 0.00264323501697729 96 688783 SGTC_184 1494-0393 24.714 µM 2.75894993994396 0.00239849238354687 no 50 0.0028993708569077 148 3090647 SGTC_269 exalamide 29 µM 2.74509081593826 0.00250645036752384 no 51 0.00302470772568459 58 3316 A derivative of salicylamide. SGTC_1063 disulfiram 1.84 µM 2.7446903021829 0.00250963454793709 no 52 0.00302840131068507 97 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2343 7990716 14.84 µM 2.74420340125311 0.00251351045272913 no 53 0.00303289704017141 74 6456862 SGTC_329 k048-0121 21.3 µM 2.7317785284744 0.0026142661247838 no 54 0.00314967351134774 75 6832902 SGTC_1578 josamycin 24.2 µM 2.73145945214379 0.00261690096679621 no 55 0.00315272497296676 65 5282165 A P450 substrate. SGTC_3185 9108267 49.47 µM 2.73118975039705 0.0026191299582041 no 56 0.00315530631944699 95 4910486 SGTC_218 alverine citrate 93.75 µM 2.69274174437747 0.00295500511419545 no 57 0.00354335695114189 84 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2695 st077686 51.995 µM 2.68951876738317 0.00298485217742211 no 58 0.00357775617098921 106 2876092 SGTC_2351 9026858 72.31 µM 2.65988257009005 0.00327230209913938 no 59 0.00390839499044484 96 1409300 SGTC_2837 9008476 45.46 µM 2.65658912330317 0.00330573651102156 no 60 0.00394677916489774 120 2992805 SGTC_1949 st076024 69.1 µM 2.64167554728238 0.00346101290075721 no 61 0.00412485213124156 112 2921930 SGTC_2846 9008642 19.48 µM 2.62310923146391 0.0036634595001914 no 62 0.00435656663407418 78 2992898 SGTC_2961 9083290 32.55 µM 2.57086409244565 0.00429134991427379 no 63 0.00507225645905955 93 17741490 SGTC_3192 9110362 49.47 µM 2.54585063337667 0.00462471931854315 no 64 0.00545059111716036 79 16649480 SGTC_1529 apigenin 74 µM 2.53180683012546 0.00482185273507049 no 65 0.00567382434297679 141 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2462 5162487 171.77 µM 2.52790367341535 0.004877955641838 no 66 0.00573729146540647 109 2259986 SGTC_260 nsc-65238 3.989 µM 2.52621043484024 0.00490247419392401 no 67 0.00576501971469851 89 3246252 SGTC_747 3448-8087 38.7 µM 2.51626744755863 0.00504867975697843 no 68 0.0059302571462568 140 5168703 SGTC_710 3448-4187 58 µM 2.51056850712282 0.0051342184666802 no 69 0.00602684656960064 202 3946412 SGTC_1515 3460-0031 42.1 µM 2.47848946524693 0.00564021020116251 no 70 0.00659700036665176 83 2876596 SGTC_1653 st012112 65 µM 2.47226603026867 0.00574335134723931 no 71 0.00671297825149937 84 720429 SGTC_1603 st002045 67.8 µM 2.45804364503053 0.00598536703903743 no 72 0.00698480978070236 97 5887985 SGTC_2614 arthonioic acid 13.39 µM 2.44880582184345 0.00614736584313469 no 73 0.00716653475312464 112 6710684 SGTC_890 0929-0006 47.2 µM 2.43820646230217 0.00633801648698185 no 74 0.00738017050258352 113 1378169 SGTC_2533 agelasine 13.65 µM 2.43694190314091 0.0063611080094815 no 75 0.00740602945077236 164 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_907 3448-6986 75.5 µM 2.42565703132084 0.00657049518837115 no 76 0.00764035170138834 147 590582 SGTC_173 1273-0061 2.693 µM 2.41503632928529 0.00677310247983941 no 77 0.0078668201579516 289 2847414 YPL266W DIM1 SGTC_2056 5235370 200 µM 2.40349133287916 0.00699958525754822 no 78 0.00811967598070308 146 5511916 SGTC_1287 0971-0001 34.6 µM 2.40287058585838 0.00701194989772214 no 79 0.00813347152698256 175 4665869 SGTC_406 estrone 100 µM 2.3977950279224 0.0071137751346338 no 80 0.00824704608520508 105 5870 A steroid. SGTC_715 0868-0130 184 µM 2.39392791082755 0.00719223020059105 no 81 0.00833451232621516 87 2876258 SGTC_1638 st008370 60.6 µM 2.3914639382996 0.00724261575991043 no 82 0.0083906662154322 158 24207134 SGTC_2098 5376439 882.5 nM 2.38864851836181 0.00730056883587135 no 83 0.00845523592081945 115 2844116 SGTC_1710 st031758 61.5 µM 2.37849929422616 0.00751288941939245 no 84 0.00869163510094458 104 5394341 SGTC_799 1310-0557 151 µM 2.36552450352021 0.00779223003315143 no 85 0.00900227590414496 142 5354492 SGTC_984 1492-0255 2.91 µM 2.35937283927894 0.00792783686622316 no 86 0.0091529267319329 128 1585198 SGTC_3211 9128781 49.47 µM 2.35932162198041 0.00792897455386261 no 87 0.00915419022369343 203 17194361 SGTC_493 zm226600 134 µM 2.34094873369169 0.00834647058893578 no 88 0.00961740406170665 143 5240098 A potassium channel opener. YCR052W RSC6 SGTC_291 SEC14.278 35.5 µM 2.33569185956152 0.00846942273424404 no 89 0.00975365353442701 116 1068044 SGTC_1620 st003704 16.5 µM 2.31933845238937 0.00886213142080684 no 90 0.0101883460115355 116 2834414 SGTC_2931 9014674 55.67 µM 2.30864482753821 0.00912747460352171 no 91 0.0104816491259793 156 2996810 SGTC_2924 9010168 62.78 µM 2.28086805313386 0.00984945264358063 no 92 0.0112781279432146 166 2993929 SGTC_583 1488-1091 88.9 µM 2.28034414073995 0.00986353636215334 no 93 0.0112936428907026 175 4303273 SGTC_832 4083-0019 164 µM 2.27910371511056 0.00989695138919659 no 94 0.0113304503672397 337 1990758 SGTC_1896 st058441 89 µM 2.26086836873733 0.010399710247671 no 95 0.0118837046869255 135 688759 SGTC_474 dl-dihydrosphingosine 5 µM 2.26012999845027 0.0104205282633274 no 96 0.0119065919080063 168 3058739 A sphingolipid protein kinase C inhibitor. SGTC_3115 9123671 49.47 µM 2.25856534649946 0.0104647629871367 no 97 0.0119552177255738 97 3286988 SGTC_1506 4226-2149 212 µM 2.25765577597035 0.0104905528594343 no 98 0.0119835641952724 192 991114 SGTC_865 0488-0499 301 µM 2.23357678590423 0.0111937203444833 no 99 0.0127554663856683 138 9634651 SGTC_2187 6125751 200 µM 2.23196110484819 0.0112423361450913 no 100 0.0128087668568776 149 874498 SGTC_3054 9094397 49.47 µM 2.23079596890264 0.0112775088634279 no 101 0.0128473235480073 208 2598354 SGTC_852 0418-0143 439 µM 2.22644667252073 0.0114096501376272 no 102 0.0129921386047339 239 5369229 SGTC_166 k072-0058 166.424 µM 2.20767951849025 0.0119953793902123 no 103 0.0136333107858074 181 5846229 SGTC_141 0443-0274 32.331 µM 2.2066417866662 0.0120285147491942 no 104 0.0136695475880658 278 1627241 SGTC_2625 euphol 100 µM 2.20025329875085 0.0122342561655728 no 105 0.0138944643467397 194 6708538 A triterpene alcohol. SGTC_1133 3473-0247 50 µM 2.19616390403649 0.0123675501206645 no 106 0.0140401069730261 228 711311 SGTC_289 k017-0060 526 µM 2.18956716247429 0.012585222684275 no 107 0.0142778213491363 127 5512909 SGTC_926 2268-1401 59.4 µM 2.18501983071442 0.0127371948732968 no 108 0.0144436963040229 170 2931578 SGTC_408 cantharidin 100 µM 2.18067945543409 0.0128837290231342 no 109 0.0146035668233409 189 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1408 3909-7976 48.8 µM 2.17388986355631 0.0131158743870802 no 110 0.0148567037412107 193 24152374 SGTC_3029 9088683 49.47 µM 2.16150779012251 0.0135485509137432 no 111 0.0153280679246815 175 25236615 SGTC_2394 5221648 200 µM 2.16017970177273 0.0135956828290657 no 112 0.0153793804430679 209 788586 SGTC_1327 1436-0082 2.18 µM 2.15624533986819 0.0137361389735613 no 113 0.0155322564487191 169 15992205 SGTC_2806 7952793 58.44 µM 2.15555713883733 0.0137608358481348 no 114 0.0155591312059497 183 2972490 SGTC_3290 9121031 71.43 µM 2.15531956545623 0.0137693703272347 no 115 0.0155684178828274 142 17014854 SGTC_1333 1482-0047 286 µM 2.15298053067713 0.0138536408053776 no 116 0.0156601043432489 200 3811116 SGTC_1290 0986-0249 10.2 µM 2.15178599182826 0.0138968488225618 no 117 0.0157071068210964 134 53329 SGTC_1741 st038134 10.228 µM 2.15009508205405 0.0139582098493699 no 118 0.0157738472762506 227 1272587 SGTC_1994 st072947 40.9 µM 2.14802656184548 0.0140335914128021 no 119 0.0158558227137097 177 5286565 YDL195W SEC31 SGTC_2966 9084041 48.03 µM 2.14742250849373 0.0140556705731223 no 120 0.0158798301519014 198 17741380 SGTC_2561 acetosyringone 100 µM 2.13519007216023 0.0145092715594729 no 121 0.0163727437607135 230 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_714 4296-0578 26.1 µM 2.12061174517744 0.0150662678472103 no 122 0.0169772444561342 80 1589775 SGTC_909 3448-9333 149 µM 2.11786477428887 0.0151732541629674 no 123 0.0170932608203755 160 3344074 SGTC_1611 st001856 99.4 µM 2.11217614657299 0.0153968860658717 no 124 0.0173356718365274 182 647478 SGTC_1873 rapamycin 2 nM 2.09833761315186 0.0159527547933353 no 125 0.0179376660566767 264 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2118 5526350 200 µM 2.08790652128029 0.0163830441256425 no 126 0.0184031339070975 202 743594 SGTC_651 3253-0966 34.4 µM 2.08767040924197 0.016392897817583 no 127 0.0184137879301023 223 781462 SGTC_3280 9140961 49.47 µM 2.06843689709157 0.017212798860302 no 128 0.0192994793281881 163 4901226 SGTC_3118 9124250 49.47 µM 2.06720012661166 0.017266699181965 no 129 0.0193576501442084 163 1504786 SGTC_555 4296-0685 37 µM 2.06379648593114 0.0174157799568189 no 130 0.0195185082012649 187 2908540 YHR072W ERG7 SGTC_1077 5-fluorocytosine 377 nM 2.05577964480127 0.0177712697971421 no 131 0.0199018804563515 181 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 2.05377404909674 0.0178611656753206 no 132 0.0199987828738093 117 4620898 SGTC_1745 st081495 74 µM 2.05013857058291 0.0180251059401991 no 133 0.0201754552274965 306 13842402 YBL026W LSM2 SGTC_802 4112-3352 742 µM 2.03841704524659 0.0185624465076538 no 134 0.0207541215378728 230 704594 SGTC_1082 camptothecin 424.86 nM 2.03648552884202 0.018652287595769 no 135 0.0208508123862205 224 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1300 1094-0077 113 µM 2.03479508984582 0.0187312188505464 no 136 0.0209357476736226 191 5532636 SGTC_297 0986-0032 24 µM 2.02915971879095 0.0189964063395807 no 137 0.021221012451395 171 2847425 SGTC_3296 9122258 64.045 µM 2.02187206583728 0.0193440751507898 no 138 0.0215947851432014 228 4730474 SGTC_513 4245-1575 41.7 µM 2.02143062442125 0.0193653073587714 no 139 0.0216176036002795 377 719745 SGTC_2115 tiliquinol 12.7705 µM 2.02135281746416 0.0193690517271837 no 140 0.0216216276149269 171 71208 A bioactive hydroxyquinoline. SGTC_1659 st012954 42.1 µM 2.01882006854453 0.01949127365395 no 141 0.0217529622054376 172 24207262 SGTC_2849 9019321 12.99 µM 2.01818478325772 0.0195220329453096 no 142 0.0217860101596755 237 16489627 SGTC_6 0844-0013 19.835 µM 1.99419454796986 0.0207141426629885 no 143 0.0230653988737369 453 1584900 SGTC_1227 3909-8010 46.6 µM 1.98584201600288 0.0211434085509805 no 144 0.0235254343881324 220 15982272 SGTC_1727 st034309 9.9045 µM 1.98199007669904 0.0213438947512503 no 145 0.0237401756473956 303 870305 SGTC_237 nikkomycin 200 µM 1.98069529113596 0.0214116458737722 no 146 0.0238127275807587 228 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_792 4534-1957 155 µM 1.9748346054869 0.0217205912187829 no 147 0.0241434602551926 221 1717904 SGTC_877 0771-0151 33.1 µM 1.97361384512739 0.0217854151640362 no 148 0.0242128341186902 228 6166523 SGTC_3032 9089427 49.47 µM 1.97235796169056 0.0218522746461714 no 149 0.0242843786096251 213 17173707 SGTC_887 0885-0007 9.62 µM 1.96879386008679 0.0220429611656239 no 150 0.0244883838290759 255 5719458 SGTC_2872 9044037 25.97 µM 1.96747106233728 0.0221140899793773 no 151 0.0245644644259581 143 6465195 SGTC_2874 9043904 71.43 µM 1.96654415082974 0.0221640467448468 no 152 0.0246178937752511 167 4463428 SGTC_1857 st056007 79.3 µM 1.96593200957712 0.0221970908621698 no 153 0.0246532324680995 174 619834 SGTC_2013 4024628 200 µM 1.95773214518643 0.0226437522838411 no 154 0.0251307256080903 249 5230760 SGTC_1957 st077035 62.4 µM 1.95645500069549 0.022713998013647 no 155 0.0252057892288608 194 705593 SGTC_1264 0783-0040 158 µM 1.94818833694799 0.0231731380884955 no 156 0.025696215921502 230 2855798 SGTC_1690 st023502 41.2 µM 1.92974179173647 0.0242259080070717 no 157 0.0268194194914195 211 24207482 SGTC_1821 st053465 65.6 µM 1.91951491356095 0.0248266831599326 no 158 0.0274596003654001 195 675086 SGTC_1628 st004252 77.7 µM 1.91476483911327 0.0251099463497589 no 159 0.0277612502129288 257 692968 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.90912496194808 0.0254497841815671 no 160 0.0281229866600254 189 5357218 A potent inhibitor of glutathione S-transferases. SGTC_270 tamoxifen 5.46 µM 1.90759561596743 0.0255425979448551 no 161 0.0282217511065883 271 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2411 st077133 39.94 µM 1.90514782129183 0.0256917407937985 no 162 0.0283804293182387 298 1403142 YNL221C POP1 SGTC_1342 1486-1464 234 µM 1.90425530203068 0.0257463025698158 no 163 0.02843847124526 241 3253938 SGTC_1215 3852-0577 11.2 µM 1.89891121680641 0.0260750314745046 no 164 0.0287880751441886 256 2884876 SGTC_1278 0874-0585 172 µM 1.89363169305929 0.0264032287504047 no 165 0.0291369568592422 233 766306 SGTC_2797 7859098 81.82 µM 1.8878230284428 0.0267683011818147 no 166 0.0295248562840015 275 972681 SGTC_473 2-arachidonoylglycerol 10 µM 1.88406943102828 0.0270064481623137 no 167 0.0297777922471796 258 5282280 An endocannabinoid. SGTC_2060 5238662 140 µM 1.87795142808501 0.0273983935480094 no 168 0.0301939050204259 249 790130 SGTC_134 0269-0018 6.916 µM 1.87088995892893 0.0278566671271753 no 169 0.0306801675320291 369 4378915 SGTC_2381 9035592 200 µM 1.8702143659852 0.0279008443580216 no 170 0.0307270277722077 225 4749657 SGTC_1100 amiodarone 5.07 µM 1.86474254797378 0.0282608030208012 no 171 0.0311087498798449 282 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1462 k081-0014 26.5 µM 1.85652243286089 0.0288088147953649 no 172 0.0316895642806436 159 3270634 SGTC_2006 4011487 200 µM 1.84939490391872 0.0292911112809883 no 173 0.0322004053820994 360 45595294 SGTC_1430 4049-0248 69.1 µM 1.84498510064211 0.029592852331621 no 174 0.0325198530056874 295 22774488 SGTC_3207 9114163 49.47 µM 1.84250639270535 0.0297635876831224 no 175 0.0327005561506909 335 849233 SGTC_2944 9067346 25.62 µM 1.83629306160081 0.0301951614127926 no 176 0.033157162693475 305 6473075 SGTC_2191 5911152 200 µM 1.83607530871915 0.0302103799693165 no 177 0.0331732597453201 262 2875902 SGTC_217 ketoconazole 989 nM 1.83435643173077 0.0303307340673164 no 178 0.0333005512229242 287 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_207 4185-0010 4.486 µM 1.8342231139112 0.0303400854318615 no 179 0.0333104408642797 359 3761753 SGTC_3282 9108498 15.4605 µM 1.83138273594496 0.0305398875428722 no 180 0.0335217181430209 287 16459645 SGTC_387 norethindrone acetate 66.7 µM 1.82891673871493 0.0307142371115202 no 181 0.0337060411317063 250 541197 SGTC_1903 st060211 78.3 µM 1.82770097625377 0.0308004961196661 no 182 0.0337972207757507 306 688960 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.82259038277614 0.031165291727945 no 183 0.0341827266553831 289 16486 A toxic proline analog. SGTC_3128 9127691 49.47 µM 1.8182009129178 0.0314814597370163 no 184 0.0345167152700586 237 41316314 SGTC_2185 6113692 200 µM 1.81364063131509 0.0318127346972013 no 185 0.0348665353580214 247 874150 SGTC_2084 5306078 60.6385 µM 1.81115729303525 0.031994340902236 no 186 0.0350582534590699 288 679340 SGTC_419 nsc-638432 893 µM 1.80614469738349 0.0323635197644136 no 187 0.0354478702962515 279 368090 SGTC_21 0849-0113 22.993 µM 1.80240870674121 0.0326409567182316 no 188 0.0357405631751148 297 1560156 SGTC_1048 3161-0300 24.5 µM 1.79549861308 0.0331592728256469 no 189 0.0362871467654802 299 2165101 SGTC_534 k292-0788 63.4 µM 1.79135652020256 0.0334732024689905 no 190 0.0366180507637478 320 4146317 SGTC_1222 0366-0074 1.18 µM 1.79121273120192 0.03348414404577 no 191 0.0366295819834674 283 286520 SGTC_2287 7945887 168.79 µM 1.78225279332751 0.0341717778246901 no 192 0.0373540085439489 271 1245853 SGTC_312 4092-0653 6.84 µM 1.78117832275982 0.0342550125311609 no 193 0.037441661885162 409 1148278 SGTC_2439 5492030 7.2 µM 1.78074527497492 0.0342886060006214 no 194 0.0374770365930691 263 5722370 SGTC_1188 1403-0014 4.57 µM 1.77879537466027 0.0344402041748692 no 195 0.0376366578931392 365 9614867 SGTC_2729 fluphenazine 10.66 µM 1.77710398009996 0.0345721500333873 no 196 0.0377755667272167 305 3372 An atypical antipsychotic. SGTC_3246 9135460 32.98 µM 1.7609850994262 0.0358505354199365 no 197 0.039120462510772 209 41446951 SGTC_2818 7996756 12.99 µM 1.75662086468075 0.036203247704239 no 198 0.0394912270886207 214 2241621 SGTC_233 rapamycin 362 pM 1.75306214600549 0.0364929576024171 no 199 0.0397956701399298 290 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1571 st070080 73.4 µM 1.7514049763522 0.0366285111826778 no 200 0.0399380882082543 304 4315245 SGTC_1429 4049-0205 9.46 µM 1.74025807942694 0.0375510467561498 no 201 0.0409068557061673 314 22774478 SGTC_215 1287-0124 461.5 µM 1.7376143698506 0.0377726054388224 no 202 0.0411393930456166 215 5560863 SGTC_1755 st041960 45.185 µM 1.7362328166746 0.037888811652914 no 203 0.0412613384546797 294 2257073 SGTC_1813 st051246 8.6015 µM 1.73465154164238 0.0380221748753291 no 204 0.0414012721465332 248 5291959 SGTC_1956 st077085 54 µM 1.73372096514939 0.0381008376354258 no 205 0.0414838023919714 347 24208685 SGTC_442 cape 100 µM 1.73297021222259 0.0381643963913558 no 206 0.0415504816982657 261 5281787 SGTC_755 1995-0008 37.3 µM 1.72201416127103 0.0391018128323929 no 207 0.0425334766101691 293 689533 SGTC_1885 st057546 99.9 µM 1.72035907598645 0.0392450405929251 no 208 0.0426835955362744 340 702008 SGTC_95 0471-0001 561.058 µM 1.7197010747417 0.0393021011864594 no 209 0.0427433961901391 330 4015405 SGTC_182 3448-4371 550.524 µM 1.71799574276541 0.039450298532377 no 210 0.0428986958990443 345 3491403 SGTC_2317 5986382 200 µM 1.71758070845972 0.0394864346834489 no 211 0.0429365607954968 296 877883 SGTC_558 k064-0027 21.3 µM 1.71756822636753 0.0394875218894966 no 212 0.0429376999945528 325 5088526 SGTC_2092 5303694 80.6725 µM 1.71721588706183 0.0395182211356201 no 213 0.0429698669078399 343 1963699 SGTC_256 clotrimazole 625 nM 1.71172016984928 0.0399995795520373 no 214 0.0434741248748322 323 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_157 1348-1695 65.819 µM 1.71125733432048 0.0400403349493524 no 215 0.0435168093968018 414 5380510 SGTC_1700 st030840 7.9285 µM 1.70890115314054 0.0402483340071919 no 216 0.0437346304448849 324 5499307 SGTC_3045 9092950 49.47 µM 1.7015553463968 0.0409024464703777 no 217 0.0444193771406488 339 44120432 SGTC_3273 9137859 49.47 µM 1.69694261809102 0.0413175795903022 no 218 0.0448537548147905 252 2377234 SGTC_2258 7960471 200 µM 1.69055232633603 0.0418983246057501 no 219 0.0454611682071741 248 2974708 SGTC_1146 3579-1023 7 µM 1.68554907473826 0.0423576145607331 no 220 0.0459413424825417 369 X1146 SGTC_2257 7960413 200 µM 1.67958550797463 0.0429103711176671 no 221 0.0465189946299683 373 2974689 YIL048W NEO1 SGTC_229 benomyl 22.8748 µM 1.66228312741072 0.0445471617815305 no 222 0.0482280096101111 373 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2867 9039098 71.43 µM 1.65959011700017 0.0448063836196062 no 223 0.0484984689372857 356 6463460 SGTC_3006 9075424 71.4286 µM 1.65300635473436 0.0454452345960942 no 224 0.0491647851329495 338 7465181 SGTC_3035 9091303 49.47 µM 1.65206686050052 0.045536992118877 no 225 0.0492604608563267 295 25237002 SGTC_930 2810-3379 265 µM 1.64265576092034 0.0464643882797592 no 226 0.0502270883718874 398 1015764 SGTC_2762 leflunomide 42.06 µM 1.64154743883563 0.0465745962384104 no 227 0.0503419140615845 391 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2779 methotrexate 400 µM 1.64107235142119 0.0466219015807124 no 228 0.0503911986396668 356 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1898 st060199 18.6 µM 1.63869863939332 0.0468588343742572 no 229 0.050638018783721 313 688866 SGTC_2275 7947463 200 µM 1.62662680687397 0.0480787714126824 no 230 0.0519081911901374 333 1225414 SGTC_106 0092-0003 11.579 µM 1.61985517002589 0.0487741380448301 no 231 0.0526316958982829 272 1072148 SGTC_319 1348-1596 45.5 µM 1.6173963836934 0.0490286065323864 no 232 0.0528963729257768 383 5380505 SGTC_396 dithiazanine 1.25 µM 1.61355309597684 0.0494284853057459 no 233 0.0533121987976724 307 10578 An antihelmenthic. SGTC_2188 6126565 140.678 µM 1.60873010498176 0.0499339770899746 no 234 0.0538376850022825 286 874518 SGTC_929 2805-0021 398 µM 1.59652667476811 0.0512314269679569 no 235 0.0551856275594592 351 3098024 SGTC_3286 9117135 37.221 µM 1.59485098803963 0.0514116590986027 no 236 0.0553727809539056 381 3438150 SGTC_1968 st069590 43.6 µM 1.59482743044083 0.0514141964774207 no 237 0.055375415613138 345 6384066 SGTC_569 4130-2812 160 µM 1.58873048149183 0.052074251938356 no 238 0.0560606270604167 261 743552 SGTC_2997 9067075 71.4286 µM 1.5844896484855 0.052537320898899 no 239 0.0565411677215364 418 27209819 SGTC_101 0490-5701 117.494 µM 1.58320826809931 0.0526778797221545 no 240 0.0566870012873385 319 4661669 SGTC_1125 tnp00248 1.32998 µM 1.58312570848163 0.0526869461804446 no 241 0.0566964075271778 492 24207736 SGTC_2342 7990637 118.86 µM 1.58183311929044 0.052829056096699 no 242 0.0568438360746595 405 2033102 YER133W GLC7 SGTC_2853 9015042 58.44 µM 1.57946420873261 0.0530902881428606 no 243 0.057114809882411 343 6457456 SGTC_2956 9076196 2.52 µM 1.55336071189418 0.0560371583430673 no 244 0.0601684917171786 400 16423868 SGTC_631 k072-0230 41.5 µM 1.55284079120492 0.0560971375394015 no 245 0.0602305874200577 425 5773147 SGTC_2713 st079149 53.4 µM 1.54917019964688 0.056522026638244 no 246 0.0606704055709261 407 3103253 SGTC_1277 0873-0036 22 µM 1.54080616650987 0.0574996769914938 no 247 0.0616819840992906 447 5965735 SGTC_1847 st056231 15 µM 1.53622673971839 0.0580405622230134 no 248 0.0622413900048311 482 5393180 SGTC_227 fluconazole 33.516 µM 1.53085633979554 0.058679955928745 no 249 0.0629024508741904 485 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1781 st038725 66.3 µM 1.52862321034965 0.0589474518959694 no 250 0.0631789393317253 515 4270275 YIL048W NEO1 SGTC_966 1300-0360 30.2 µM 1.52620390330639 0.059238327884954 no 251 0.0634795458428397 402 70588 SGTC_2557 derrustone 83.84 µM 1.52568745212087 0.0593005669275445 no 252 0.0635438604739503 464 629853 An antioxidant. SGTC_843 0310-0051 143 µM 1.51779269769153 0.0602583827380977 no 253 0.0645333332753262 400 2065037 SGTC_1795 st049545 62.3 µM 1.51471453995135 0.0606350991526045 no 254 0.0649223553238631 394 5291882 SGTC_1076 itraconazole 331 nM 1.51315661860115 0.0608264642365384 no 255 0.0651199403240111 419 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_944 3370-0224 231 µM 1.51205100293501 0.0609625572505108 no 256 0.0652604440504247 408 4580514 SGTC_2954 9074818 52.69 µM 1.50925443258366 0.0613078567197298 no 257 0.0656168873353464 427 16648742 SGTC_1353 1498-1206 8.11 µM 1.50466761648349 0.0618775084320632 no 258 0.066204776372903 491 6756808 SGTC_3136 9095672 49.47 µM 1.50457007026691 0.0618896677263944 no 259 0.0662173229616713 355 17217380 SGTC_706 4262-0057 46.9 µM 1.49869624449601 0.0626252925883752 no 260 0.0669762257202595 417 883298 SGTC_3289 9119912 71.43 µM 1.49842662241426 0.0626592223566659 no 261 0.0670112219231563 417 17014829 SGTC_2029 5175081 200 µM 1.49784313235828 0.0627326989358766 no 262 0.0670870057450652 458 1380876 SGTC_2377 9073351 62.6 µM 1.49390785449815 0.0632300076811284 no 263 0.0675998526092928 416 7337946 YHR072W ERG7 SGTC_1524 corynanthine 62.1 µM 1.49122709166672 0.0635705349553415 no 264 0.0679509415821168 412 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2067 5224629 34.075 µM 1.49033890416011 0.0636836722851854 no 265 0.0680675740173346 443 2835000 SGTC_433 pimozide 108 µM 1.48863594212974 0.0639010336522841 no 266 0.0682916308208599 323 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_509 pifithrin 175 µM 1.48863538103 0.0639011053644664 no 267 0.0682917047378036 365 4817 A p53 inhibitor. SGTC_2259 7964009 200 µM 1.48521264248809 0.0643397193617157 no 268 0.0687437520296784 389 313134 SGTC_3323 9138564 53.9225 µM 1.48134828924194 0.0648377328825304 no 269 0.0692568933853267 480 43912313 YNL103W MET4 SGTC_1323 1348-1351 11.2 µM 1.47046886442641 0.0662558837823461 no 270 0.0707174061577821 402 6989654 SGTC_3067 9117431 49.47 µM 1.46870986629145 0.0664874111885292 no 271 0.0709557501199091 380 17150885 SGTC_1864 st057645 30.4 µM 1.46858333280755 0.0665040902245007 no 272 0.0709729191471436 385 688666 SGTC_176 1486-1328 72.834 µM 1.46651854497527 0.0667767185423959 no 273 0.0712535363710156 486 22310231 SGTC_1701 st028638 40.4 µM 1.46598873367342 0.0668468124448982 no 274 0.0713256780913054 430 3490878 SGTC_2050 5263056 171 µM 1.46520969484398 0.0669499824569808 no 275 0.0714318576761546 517 763468 YGL055W OLE1 SGTC_415 dibenzyl ketone 100 µM 1.46519766155025 0.0669515770208202 no 276 0.0714334987123078 432 7593 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.4524033575675 0.0686636650272792 no 277 0.0731947416390636 489 442882 SGTC_2871 9038510 12.99 µM 1.45083276205475 0.0688761426429871 no 278 0.0734132172130427 452 4945164 SGTC_3241 9133421 49.47 µM 1.44805724676795 0.069252866402058 no 279 0.0738005205132821 351 17018221 SGTC_2968 9090663 33.37 µM 1.44385572535527 0.0698261612916558 no 280 0.0743897814895155 453 25236811 SGTC_1801 st050089 28.441 µM 1.44340138425728 0.069888374049458 no 281 0.0744537171969493 577 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1307 1187-1599 12.2 µM 1.44152638593078 0.0701455682043699 no 282 0.0747180142419492 447 1538471 SGTC_954 1189-0853 2.85 µM 1.43826747580165 0.0705943255799031 no 283 0.0751790881993083 461 2828194 SGTC_582 0987-0078 156 µM 1.43778574044725 0.0706608481257313 no 284 0.0752474282590105 616 1625765 SGTC_1743 st037606 46.3785 µM 1.43597480794728 0.0709113497029222 no 285 0.0755047549209798 448 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2810 7959871 45.46 µM 1.4342461242711 0.0711511098876721 no 286 0.0757510194035554 531 2974535 SGTC_891 0929-0073 133 µM 1.43413824375753 0.0711660930103545 no 287 0.0757664080826558 441 5603632 SGTC_1177 0983-0204 23.6 µM 1.4327696710577 0.0713563793446794 no 288 0.075961835701721 489 766818 SGTC_581 0958-0271 211 µM 1.42618874093423 0.0722768500781108 no 289 0.0769069343577357 567 4591145 SGTC_231 b-estradiol 524 µM 1.42491490427375 0.0724560673397449 no 290 0.0770909003939993 388 450 A steroid. SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.42313819088473 0.0727066031088645 no 291 0.0773480495586662 470 5377381 SGTC_224 benfluorex 43.875 µM 1.42092654270223 0.0730193955747374 no 292 0.0776690578490409 333 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1442 4112-3290 3 µM 1.42009296305027 0.0731375552659443 no 293 0.0777903093341575 480 704353 SGTC_3130 9127414 49.47 µM 1.418674777439 0.0733389188194157 no 294 0.0779969269588458 428 1494646 SGTC_1750 st081859 2.357 µM 1.41408146212289 0.0739940202492015 no 295 0.0786689927206804 673 5291695 SGTC_2189 6047310 154.431 µM 1.4098390787601 0.0746030344769438 no 296 0.0792936023199767 440 711535 SGTC_2417 cerulenin 830 nM 1.40863543502149 0.0747765180397042 no 297 0.0794714976577144 431 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1391 3442-0225 151 µM 1.40309823888592 0.0755785724784944 no 298 0.0802937731367285 412 5227075 SGTC_671 0560-0003 407 µM 1.40009326470904 0.076016573539849 no 299 0.080742695856897 458 3238678 SGTC_905 2-aminofluorene 215 µM 1.39931006616937 0.0761310483974734 no 300 0.080860011175656 507 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2271 7849410 118.62 µM 1.39914987222453 0.0761544790245881 no 301 0.0808840224732075 463 972430 SGTC_2712 st079126 47.7 µM 1.39721264976926 0.0764382598722028 no 302 0.0811748169344578 450 3152970 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.39698865701417 0.0764711240605058 no 303 0.0812084910702543 502 5711223 A potent inhibitor of glutathione S-transferases. SGTC_150 3970-0969 77.2 µM 1.391482950587 0.0772823039617608 no 304 0.0820395130848777 573 6615640 SGTC_2780 5215298 71.43 µM 1.38682410732832 0.0779738037136663 no 305 0.0827477020887396 513 2834131 SGTC_3343 9148379 18.9835 µM 1.38662933356072 0.0780028153767012 no 306 0.0827774094446405 471 1955036 SGTC_2076 5212012 200 µM 1.38565714768954 0.0781477454854625 no 307 0.0829258095399517 382 604802 SGTC_2314 7727897 200 µM 1.38536373072897 0.0781915271739355 no 308 0.0829706377017064 471 900724 SGTC_2024 5144227 134 µM 1.38193011081204 0.0787052522039089 no 309 0.0834965807156509 539 3475211 SGTC_2465 5809242 33.21 µM 1.38055533227115 0.0789116568566363 no 310 0.0837078627182466 440 2731748 SGTC_1022 4477-0945 21.3 µM 1.38019011554809 0.0789665581481166 no 311 0.0837640582913021 505 4648966 SGTC_2429 5902844 64.44 µM 1.37921132866765 0.0791138371892252 no 312 0.0839148030986162 508 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_383 2324-0395 7.37 µM 1.37917536670701 0.0791192523804168 no 313 0.0839203455453534 506 3146421 SGTC_450 aminopyrene 156 nM 1.3785402023019 0.0792149423923644 no 314 0.0840182822068118 496 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2726 cimetidine 79.27 µM 1.37799879643859 0.0792965764664224 no 315 0.0841018298693934 411 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1182 1222-0449 220 µM 1.37766622108022 0.079346754297262 no 316 0.0841531825293712 477 658318 SGTC_993 3909-8757 62.7 µM 1.37673670560591 0.0794871238670704 no 317 0.0842968329938423 450 4288324 YLR208W SEC13 SGTC_1469 k284-2957 126 µM 1.37422326654983 0.0798676286465159 no 318 0.0846861898697097 463 23884841 SGTC_2618 avocadyne 43.43 µM 1.37269201314719 0.0801001165077238 no 319 0.084924056587039 465 3015189 SGTC_1920 st075728 45.7 µM 1.37215913792089 0.0801811420210953 no 320 0.0850069514254052 482 3400306 SGTC_2819 7996655 46.38 µM 1.37175961597267 0.0802419313339013 no 321 0.0850691414064036 429 6456960 SGTC_2158 5657123 3.6195 µM 1.37142159931022 0.080293389497857 no 322 0.0851217840373082 471 2858827 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.36902784360547 0.080658518169079 no 323 0.0854952857607152 500 115019 SGTC_2401 5128683 200 µM 1.36680297805608 0.080999008479472 no 324 0.0858435345466344 465 708373 SGTC_268 camptothecin 39.6153 µM 1.36546971920299 0.0812035677552252 no 325 0.0860527320418845 611 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_763 3453-1109 128 µM 1.36439445946472 0.0813688264855729 no 326 0.0862217253694864 504 1560353 SGTC_942 3253-1115 227 µM 1.36328474999919 0.0815396457375789 no 327 0.0863963931538189 513 46497897 SGTC_675 1309-0189 238 µM 1.36068264728032 0.0819412516048514 no 328 0.0868070003561886 492 4246530 SGTC_2912 7964298 10.93 µM 1.36053178598178 0.0819645810152194 no 329 0.0868308506450903 585 2975850 SGTC_181 1447-1644 8.07 µM 1.35563776784611 0.0827241165902897 no 330 0.0876072244631748 501 534600 SGTC_2520 obtusaquinone 4.71 µM 1.35487674837443 0.0828426986249996 no 331 0.0877284144330803 499 5967872 SGTC_718 1130-0073 349 µM 1.35446773610767 0.0829064837213472 no 332 0.0877936000065297 535 6740020 SGTC_1829 berberine 14.4 µM 1.35274884628552 0.083174946981463 no 333 0.0880679398864734 493 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1387 3342-1166 1.8 µM 1.35012186183745 0.0835865023308648 no 334 0.088488448438071 425 3418228 SGTC_3019 9081971 49.47 µM 1.34802627562236 0.0839159021017712 no 335 0.0888249658206912 544 16451803 SGTC_1466 k213-0079 57.5 µM 1.34709545955628 0.0840625269478392 no 336 0.088974745145377 531 3657981 SGTC_445 e6 berbamine 66 µM 1.34634938027843 0.0841801903251439 no 337 0.0890949338099157 653 6610268 A calcium/calmodulin antagonist. SGTC_306 1672-3436 11.6 µM 1.33922847879748 0.0853094475797064 no 338 0.0902481519752832 531 6797378 SGTC_1757 st041620 31.8375 µM 1.3380648047822 0.0854950608482384 no 339 0.0904376562589106 521 5289815 SGTC_3072 9116419 49.47 µM 1.33751053442582 0.085583576695564 no 340 0.0905280229852379 452 17170162 SGTC_410 α-linolenic acid 100 µM 1.33717462324441 0.0856372544129643 no 341 0.0905828216412266 547 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_863 0466-0191 129 µM 1.33712629740667 0.085644978827481 no 342 0.0905907072715011 576 765160 YPR165W RHO1 SGTC_2877 9040724 71.43 µM 1.33362832546476 0.0862054820203611 no 343 0.0911628475586281 505 6463895 SGTC_2975 9084847 53.72 µM 1.33045722142979 0.0867159761031792 no 344 0.09168383602204 529 27211724 SGTC_1185 1319-0113 81.3 µM 1.32176122188081 0.0881274734204776 no 345 0.0931238374726863 468 4672763 SGTC_931 2812-0076 566 µM 1.32008992004938 0.088400703275377 no 346 0.0934024988972809 558 3450959 SGTC_2012 4023501 200 µM 1.31969839058331 0.0884648029467193 no 347 0.0934678688005612 493 3477460 SGTC_2338 7999974 200 µM 1.31706229618599 0.0888972757201846 no 348 0.0939088719519396 569 315925 SGTC_2731 amoxapine 43.43 µM 1.31573048350803 0.0891163680375648 no 349 0.0941322594677525 387 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1216 1165-0504 9.65 µM 1.31520350554263 0.0892031703990059 no 350 0.0942207586670667 550 6304004 SGTC_360 0957-0399 1.01 µM 1.31373041448509 0.089446147620919 no 351 0.0944684709864654 568 6752301 YPR165W RHO1 SGTC_1457 k015-0032 57.3 µM 1.31288745104093 0.089585410469465 no 352 0.0946104380246078 541 4302660 SGTC_1507 4075-3230 155 µM 1.31234314958725 0.0896754181095691 no 353 0.0947021896542528 465 659771 SGTC_3239 9133757 49.47 µM 1.31116753462756 0.0898700514207713 no 354 0.0949005840860944 507 17036923 SGTC_3046 9092212 49.47 µM 1.30712055299525 0.0905424653427924 no 355 0.0955858860034992 511 25236637 SGTC_1902 st060212 70.5 µM 1.30319830989395 0.0911977107754161 no 356 0.096253533500933 549 688944 SGTC_659 k018-0002 107 µM 1.30179184637304 0.0914335274450469 no 357 0.0964937759220281 558 6797879 YHR007C ERG11 SGTC_162 k030-0015 37.8 µM 1.30076767819512 0.0916055302125531 no 358 0.0966689942904496 537 1809920 YMR134W ERG29 SGTC_2406 ethylparaben 405.7 µM 1.30033385746565 0.0916784599908426 no 359 0.0967432843166161 468 8434 A possible steroid mimic. SGTC_3174 9107204 49.47 µM 1.2947048605485 0.0926286564927624 no 360 0.0977110312915134 541 3938802 SGTC_587 k089-0003 57 µM 1.29331457808127 0.0928644594111793 no 361 0.0979511403339371 392 9659696 SGTC_26 0302-0163 425.158 µM 1.29307906150088 0.092904448811247 no 362 0.0979918580701624 540 3100915 SGTC_712 r015-0009 80.6 µM 1.29233891525769 0.0930302043833202 no 363 0.0981199004127138 483 6813872 YLR060W FRS1 SGTC_2754 granisetron 64.02 µM 1.291784224095 0.0931245324036157 no 364 0.0982159400909173 574 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3061 glucosamine 200 µM 1.28642748190363 0.0940391131129429 no 365 0.0991469561971788 526 91431 and experimental redox chemotherapeutic SGTC_2897 9048598 12.99 µM 1.28202752186592 0.0947952821806 no 366 0.0999164959324553 532 6467404 SGTC_3302 9125395 16.351 µM 1.28189988079561 0.0948172850222425 no 367 0.0999388848971129 535 17599668 SGTC_2174 5790901 200 µM 1.2811820073466 0.0949411025669933 no 368 0.100064872206606 532 786020 SGTC_49 0717-0965 32.132 µM 1.28070528439225 0.0950233926913349 no 369 0.100148601481371 563 5889349 YGL099W LSG1 SGTC_1104 tacrolimus 29.8 µM 1.28063501074272 0.0950355275063543 no 370 0.100160948323757 606 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1575 cyproterone acetate 48 µM 1.28036969312353 0.0950813526966342 no 371 0.100207573749227 548 9880 An androgen receptor antagonist and liver toxin. SGTC_1045 1348-1485 165 µM 1.28020870111473 0.0951091668845007 no 372 0.100235873301459 614 6810614 SGTC_1993 st073995 70.8 µM 1.27993201846563 0.0951569826541618 no 373 0.100284522852688 568 3098394 SGTC_641 4092-0595 30 µM 1.27948442023581 0.0952343732107489 no 374 0.100363261249942 575 786260 SGTC_1948 st076329 66.6 µM 1.27902863210009 0.0953132274325817 no 375 0.100443486710621 510 24208413 SGTC_1974 st069448 26.9 µM 1.27825876677748 0.0954465281396801 no 376 0.100579100657224 527 6323587 YNR016C ACC1 SGTC_1514 1189-1591 158 µM 1.27571221032821 0.0958884371399021 no 377 0.101028635327501 611 767698 YMR146C TIF34 SGTC_815 1582-0027 36.9 µM 1.27527573485729 0.0959643304185425 no 378 0.101105831603189 562 3128206 SGTC_3226 9131256 49.47 µM 1.27516382705698 0.0959837957837351 no 379 0.101125630852888 424 17178073 SGTC_585 0kpi-0023 191 µM 1.27334733146666 0.0963001651923236 no 380 0.101447409003875 521 64601 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.27281062179301 0.0963937875855593 no 381 0.101542625550635 536 5355888 SGTC_1046 2001-0062 216 µM 1.27169347902838 0.0965888738508342 no 382 0.101741024214595 558 739778 SGTC_996 3970-0799 1.8 µM 1.26792231250214 0.0972495733792576 no 383 0.102412847568399 742 6615648 YGL040C HEM2 SGTC_2480 5767542 37.17 µM 1.26724485844614 0.0973686122692741 no 384 0.102533875231694 566 2867358 SGTC_2166 5933061 31.504 µM 1.26638828944219 0.0975192773327351 no 385 0.102687050720356 563 2877375 SGTC_2181 6316240 54.2555 µM 1.26492194008414 0.0977775956663718 no 386 0.102949655784682 520 12779990 SGTC_2404 5161160 200 µM 1.26356296871596 0.0980174453722727 no 387 0.103193466060986 593 2831543 SGTC_339 3091-4833 71.4 µM 1.25794114697357 0.0990142419516497 no 388 0.104206520670213 568 3240077 SGTC_1320 1313-0481 95.3 µM 1.25527223099553 0.0994900507204607 no 389 0.104689976096752 580 6813365 YLR208W SEC13 SGTC_2247 cerulenin 830 nM 1.2527009544614 0.0999500310360581 no 390 0.105157279250047 580 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2751 anetholtrithion 17.25 µM 1.25211444346356 0.100055170242293 no 391 0.105264082715312 578 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1662 st014054 52 µM 1.25081342257341 0.100288682207935 no 392 0.105501278300388 540 2838777 SGTC_314 1671-0008 2.74 µM 1.25024800986231 0.100390288440523 no 393 0.105604481913665 634 3913060 SGTC_2305 7443522 69.23 µM 1.24995254699704 0.100443413811373 no 394 0.105658441171501 605 5415886 SGTC_1643 st009866 20.2 µM 1.24812573391351 0.100772337463334 no 395 0.105992507780342 550 3156273 YOR207C RET1 SGTC_2603 homopterocarpin 100 µM 1.24767523827415 0.100853571273914 no 396 0.106075006440884 607 101795 A weak amylase inhibitor. SGTC_2598 perillyl alcohol 100 µM 1.24753504326533 0.100878861112789 no 397 0.106100689627157 593 10819 An apoptosis inducer. SGTC_3222 9128301 49.47 µM 1.24706978866103 0.100962821727325 no 398 0.106185954674179 582 4911358 SGTC_2617 dihydrotanshinone i 20.83 µM 1.24601687548935 0.101153020251666 no 399 0.10637909990625 618 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2022 5136654 200 µM 1.24597440309368 0.101160697952121 no 400 0.106386896315317 570 1713771 SGTC_595 3909-8003 73.7 µM 1.24523666142969 0.101294126674417 no 401 0.106522385066913 583 699517 SGTC_2020 4017018 200 µM 1.24432137565936 0.101459844372791 no 402 0.106690653482675 578 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2386 9075165 157.42 µM 1.23827586296366 0.102559380567781 no 403 0.107806895222092 567 16452277 SGTC_823 0417-1665 178 µM 1.23702400842902 0.10278814194988 no 404 0.108039084798661 588 3429856 SGTC_1173 0443-0020 122 µM 1.23600177787957 0.102975217140184 no 405 0.108228951405101 586 5331295 SGTC_2732 terfenadine 20 µM 1.23493873946803 0.103170022665226 no 406 0.108426652174965 528 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_492 tmb-8 126 µM 1.23364791288625 0.103406930785472 no 407 0.108667065480555 416 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3058 9093861 49.47 µM 1.23357866833164 0.103419650535048 no 408 0.108679972936177 577 17217477 SGTC_462 ag-879 158 µM 1.23083625331004 0.103924326913818 no 409 0.109192056704622 636 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2371 9071574 200 µM 1.23032102041817 0.104019342260835 no 410 0.109288457899582 528 45596039 SGTC_42 0133-0086 60.653 µM 1.2302435437104 0.104033635374827 no 411 0.109302959246941 545 162923 Model of phenazepam hydroxylation. SGTC_1190 1486-1332 13 µM 1.22954853009797 0.104161917068717 no 412 0.109433107053474 584 4150046 SGTC_936 3005-4620 401 µM 1.22808270393277 0.104432846874674 no 413 0.109707961562597 657 777207 SGTC_2715 st079500 56.4 µM 1.22614492120559 0.104791791971033 no 414 0.110072071943434 558 28246688 SGTC_1376 2910-0861 41.3 µM 1.22496934507264 0.10500998468552 no 415 0.110293385385088 633 1112859 SGTC_1588 farnesol 29.9 µM 1.22489536307779 0.105023727098595 no 416 0.110307323868169 603 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_305 1682-2595 20.8 µM 1.21335470969 0.107183411152857 no 417 0.112497117083099 628 226033 SGTC_2123 5259487 200 µM 1.2115569098411 0.1075227085539 no 418 0.112841018787965 642 2173474 SGTC_3170 9103054 49.47 µM 1.2101094311419 0.107796452073589 no 419 0.113118452358166 562 16432970 SGTC_2121 5257820 149.641 µM 1.20929746521025 0.107950228627316 no 420 0.113274292172179 660 791256 SGTC_652 0437-0092 114 µM 1.20802076550559 0.108192339516078 no 421 0.113519637505293 579 3091274 SGTC_2063 5246145 200 µM 1.20463883083845 0.108835571550349 no 422 0.114171379717843 644 711240 SGTC_34 0469-0683 81.75 µM 1.20384983232563 0.108986031034904 no 423 0.114323812497441 606 3690923 SGTC_1827 berberine 7.24 µM 1.20343419936789 0.109065351005079 no 424 0.114404170121761 567 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2816 7982706 58.44 µM 1.20201825509463 0.109335883186783 no 425 0.114678227702693 598 2981853 SGTC_3326 9140064 16.379 µM 1.20072598250343 0.109583206925281 no 426 0.114928755945454 599 1868434 SGTC_3225 9130819 49.47 µM 1.20056448662489 0.109614143298234 no 427 0.114960091914233 613 4547121 SGTC_1530 rhein 70.4 µM 1.19831501143664 0.110045707994642 no 428 0.115397202369773 665 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2345 9052315 157.45 µM 1.19752355613256 0.110197839235947 no 429 0.115551275841957 616 6469265 SGTC_937 3122-0005 46.7 µM 1.19503078158766 0.110677978741954 no 430 0.116037501916752 669 759535 SGTC_1127 asiatic acid 681.4 nM 1.19353135540926 0.110967508084861 no 431 0.116330669862244 605 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_3138 9097216 49.47 µM 1.18479169603598 0.112665878082269 no 432 0.11804990831572 613 25237486 SGTC_204 PMA1.184 62.41 µM 1.18373499439374 0.112872477105528 no 433 0.118258990902857 684 2252213 YGL008C PMA1 SGTC_1254 0550-0035 264 µM 1.1821606103376 0.113180791241838 no 434 0.11857098933287 676 15121435 SGTC_126 0417-1624 672.48 µM 1.18212307464884 0.113188149241938 no 435 0.118578434938272 776 41912 YDL195W SEC31 SGTC_893 0958-0369 48.9 µM 1.18093836150574 0.113420560143517 no 436 0.118813605259312 670 6819948 SGTC_1034 k072-0165 12.7 µM 1.17627847542678 0.114338014097675 no 437 0.119741807088106 683 5835461 SGTC_1070 indatraline 8.81 µM 1.17607476046813 0.114378242381804 no 438 0.119782501366574 635 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2436 5633522 8.09 µM 1.17489060891146 0.114612280343164 no 439 0.120019241612019 664 5724242 SGTC_854 0422-0053 192 µM 1.17372223634436 0.114843533541543 no 440 0.120253150294282 629 3596728 SGTC_1706 st031321 9.9705 µM 1.17233009112342 0.115119510662142 no 441 0.120532277459585 649 6103185 SGTC_3088 9117578 49.47 µM 1.16818560036736 0.115943899857957 no 442 0.121365953779242 620 678341 SGTC_2320 7373003 200 µM 1.16772116144048 0.116036542871525 no 443 0.121459629026882 618 5415828 SGTC_3306 9127676 59.7925 µM 1.16650502594311 0.116279377946307 no 444 0.12170515886682 612 41905287 SGTC_2099 5377090 177.372 µM 1.16227943889205 0.117125935684716 no 445 0.122560987852578 643 2243829 SGTC_2829 7992743 58.44 µM 1.15989306339662 0.117605949030033 no 446 0.123046173634364 670 16462845 SGTC_728 3030-5151 22.5 µM 1.15971526380809 0.117641768624889 no 447 0.1230823767661 607 3125388 SGTC_2889 9059656 51.95 µM 1.15510096061608 0.118574070378012 no 448 0.124024542452354 702 3949838 SGTC_2380 9035439 200 µM 1.15237091653501 0.119128117109237 no 449 0.124584343414941 710 6462575 SGTC_1820 st053765 18.6 µM 1.14831454184366 0.119954705986415 no 450 0.125419369038825 630 3690829 SGTC_1149 3909-7961 23.3 µM 1.14556490778921 0.12051730750301 no 451 0.125987612133469 655 735261 SGTC_3070 9117005 49.47 µM 1.14346263775341 0.120948703729757 no 452 0.126423279331734 615 8779016 SGTC_1252 0493-0875 34.8 µM 1.13523131636404 0.122648263577115 no 453 0.128139205716393 649 3960963 SGTC_1228 0124-0032 52.5 µM 1.13398400580462 0.12290725622113 no 454 0.128400628556393 681 X1228 SGTC_393 acivicin 6.25 µM 1.13096845257723 0.123534991849956 no 455 0.129034184910773 609 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2245 6637752 200 µM 1.12913856893715 0.123917004305964 no 456 0.129419691658243 588 681890 SGTC_953 1188-0045 9.7 µM 1.12459592918699 0.124868912065213 no 457 0.130380149764946 697 6144426 SGTC_1265 0819-1001 68.8 µM 1.12266899468734 0.125274239485819 no 458 0.13078905042012 647 3106768 SGTC_285 1486-1325 46 µM 1.12234446323287 0.125342594409447 no 459 0.130858003981409 724 22310230 SGTC_1477 0139-0234 16 µM 1.12150647174824 0.125519218023772 no 460 0.131036169150441 694 620880 SGTC_2942 9052777 62.25 µM 1.12067929973135 0.125693731483749 no 461 0.131212198285132 745 6469503 SGTC_1067 clotrimazole 1.36 µM 1.11735349313238 0.126397105115384 no 462 0.13192160587772 723 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1159 4092-0538 61.2 µM 1.11296152917735 0.127330155371288 no 463 0.132862476180939 731 717301 SGTC_74 000s-0487 160.283 µM 1.11253933327538 0.127420100483509 no 464 0.132953164098631 663 677548 SGTC_2065 5221596 34.26 µM 1.11146430983397 0.127649324212177 no 465 0.133184272113693 671 788581 SGTC_1766 st045414 44.774 µM 1.1112615516081 0.127692589797128 no 466 0.133227891947423 743 253960 SGTC_2096 5468907 200 µM 1.11072622017706 0.127806870531893 no 467 0.133343106240763 672 759785 SGTC_443 clozapine 122 µM 1.10626813376792 0.128761328555559 no 468 0.134305240070611 598 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2725 haloperidol 53.21 µM 1.10482655280604 0.129071020510269 no 469 0.134617376292904 698 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3108 9121785 49.47 µM 1.10167680297465 0.12974947089735 no 470 0.135301102622233 685 17140271 SGTC_2661 dactinomycin 12.96 µM 1.09856320589027 0.130422557422566 no 471 0.135979317044675 743 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_1418 3966-3099 2.4 µM 1.09793002143049 0.13055973199811 no 472 0.136117523751966 721 740335 SGTC_640 3381-0960 37.1 µM 1.0972314719363 0.130711183117334 no 473 0.136270109353061 740 1745025 SGTC_148 3253-0744 288.01 µM 1.09423825850717 0.131361510633383 no 474 0.136925248013793 684 6893655 SGTC_1369 1866-0067 208 µM 1.09353759950342 0.131514063084451 no 475 0.137078914932778 776 3531355 SGTC_1219 1469-0211 33.1 µM 1.09327981803652 0.131570219855781 no 476 0.137135480608406 682 6822282 SGTC_1036 k216-0215 33.5 µM 1.09054236126555 0.132167586163625 no 477 0.137737151855851 728 622330 SGTC_3256 9138902 49.47 µM 1.08777836892755 0.132772637599917 no 478 0.138346480512634 747 17228773 SGTC_3339 9145883 14.936 µM 1.08630312117818 0.133096356142948 no 479 0.138672453303053 689 2030670 SGTC_2094 5332512 191.667 µM 1.08175055870889 0.134098763163371 no 480 0.139681690482541 752 755774 SGTC_2155 5570423 76 µM 1.08017722242923 0.134446391449995 no 481 0.140031634671058 688 797402 SGTC_1154 4088-0362 150 µM 1.07918285023996 0.13466641656972 no 482 0.140253111628763 784 6618304 SGTC_1164 k060-0068 93.7 µM 1.07791763873599 0.134946727475908 no 483 0.14053525652255 768 5963676 SGTC_317 4495-0002 170 µM 1.07778645857754 0.134975813664374 no 484 0.140564532010621 666 15991618 SGTC_519 k048-0011 62.8 µM 1.07506467552221 0.135580276848449 no 485 0.141172886646517 714 6836379 SGTC_958 1222-0007 33 µM 1.07071546649948 0.136550009054742 no 486 0.142148693145324 782 7312461 SGTC_336 4111-0029 111 µM 1.06703846480476 0.137373552812089 no 487 0.1429772334682 674 3131175 SGTC_209 4077-0173 175.592 µM 1.06676793178711 0.137434278175772 no 488 0.143038321404351 619 15993494 SGTC_375 3970-0961 9.27 µM 1.06441520770235 0.13796315663255 no 489 0.143570323762579 745 2898222 SGTC_943 3253-1379 105 µM 1.06431564303177 0.137985568757763 no 490 0.14359286692894 722 668464 SGTC_119 0121-0043 24.815 µM 1.06260864384587 0.13837020257284 no 491 0.143979732729109 886 1092378 SGTC_849 0386-0493 241 µM 1.0598618236626 0.138990669440219 no 492 0.1446037328864 721 726119 SGTC_2558 carylophyllene oxide 100 µM 1.05955296194086 0.139060555107786 no 493 0.144674011340192 791 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2438 5259590 200 µM 1.05931301762102 0.139114863447055 no 494 0.144728624191824 777 1201127 SGTC_1488 4013-0813 75.9 µM 1.05850047999363 0.139298878189933 no 495 0.144913666028288 702 2910057 SGTC_796 1234-0020 70.7 µM 1.05675443592234 0.139694863501054 no 496 0.145311837019553 706 46495034 SGTC_2591 skatole 100 µM 1.05509669796686 0.140071529487536 no 497 0.145690551038615 735 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_149 3970-0822 46.1 µM 1.05436892709436 0.140237109055546 no 498 0.145857021365967 872 3114250 YBL034C STU1 SGTC_2905 7799065 20.05 µM 1.05379343800919 0.140368136161832 no 499 0.145988749230318 715 1296806 SGTC_738 1315-0003 72.4 µM 1.05263244393764 0.140632723743589 no 500 0.146254740795589 770 6251474 SGTC_376 3970-0862 59.1 µM 1.05193541333005 0.140791737753959 no 501 0.146414591464298 772 3135186 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.05108672753227 0.140985513591729 no 502 0.146609379649236 743 390807 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.05037866251672 0.14114732060178 no 503 0.146772025930646 803 5357218 A potent inhibitor of glutathione S-transferases. SGTC_228 caffeine 993.056 µM 1.05022884666488 0.141181572652021 no 504 0.146806454935171 703 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1892 st058411 7.36 µM 1.05015467636005 0.141198532122047 no 505 0.146823501930557 808 3934738 SGTC_1651 st011928 86.1 µM 1.0497908671528 0.141281739208791 no 506 0.146907137561016 747 720198 SGTC_604 1000-0114 314 µM 1.04605430475268 0.142138255080502 no 507 0.147767980416829 828 1572745 SGTC_3274 9138298 49.47 µM 1.04531693269772 0.14230769397507 no 508 0.147938257132111 783 17015756 SGTC_1363 1636-0063 10.4 µM 1.03935289823077 0.143683176630396 no 509 0.149320320716139 805 6072185 SGTC_1947 st076332 61.6 µM 1.03793215381274 0.144012161088179 no 510 0.149650821349702 718 24208416 SGTC_2587 piperic acid 92.2 µM 1.03768313173663 0.144069876376149 no 511 0.149708800337578 691 5370536 SGTC_2004 4023728 41.89 µM 1.03716033703465 0.144191094071452 no 512 0.149830569651822 769 360084 YDR527W RBA50 SGTC_491 tetrandrine 80.3 µM 1.03496532979094 0.144700789271949 no 513 0.150342551417117 730 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1678 st019265 80.2 µM 1.03249274744494 0.145276390991645 no 514 0.150920671723371 788 5367020 SGTC_170 4197-0004 226 µM 1.03228439130718 0.145324965277008 no 515 0.150969455470373 707 218692 SGTC_3154 9100113 49.47 µM 1.03040213660409 0.145764272465272 no 516 0.151410635339821 747 25237525 SGTC_392 N-ethylmaleimide 8.33 µM 1.02559181190928 0.146891026085823 no 517 0.152542014311848 744 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2242 6630449 61.2675 µM 1.02518269395068 0.146987125283906 no 518 0.152638496217031 668 691249 YDR170C SEC7 SGTC_1136 pergolide 1.05886 µM 1.02262844575857 0.147588055080743 no 519 0.153241777392062 842 47811 A dopamine receptor agonist. SGTC_897 1000-0139 31.4 µM 1.02161670928364 0.147826537479358 no 520 0.1534811730373 776 6151020 SGTC_867 0518-0118 155 µM 1.02144003083638 0.147868209850762 no 521 0.153523003831001 791 6848158 SGTC_2560 caryophyllene 100 µM 1.02134082498359 0.147891612548306 no 522 0.153546495345624 852 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_850 0388-0143 75.9 µM 1.0211143005931 0.147945059030921 no 523 0.153600144259423 738 67273 SGTC_2464 5717415 7.67 µM 1.02023994434084 0.148151477129226 no 524 0.153807338865551 754 5285744 SGTC_2964 9083345 53.42 µM 1.02022561177925 0.148154862366181 no 525 0.153810736766894 716 17741579 SGTC_3057 9095946 49.47 µM 1.01974589350898 0.148268197861415 no 526 0.153924494949931 803 24540043 SGTC_136 0097-0015 404.482 µM 1.01617174815594 0.149114430590753 no 527 0.154773803688683 851 4861337 SGTC_1717 st033143 58.0435 µM 1.01549825468103 0.14927425080737 no 528 0.154934189045536 803 674616 SGTC_128 0906-2981 13.371 µM 1.014893542578 0.149417846597372 no 529 0.155078288338001 717 6740226 SGTC_2157 5649910 96.377 µM 1.0094488436787 0.150714904294452 no 530 0.156379711871632 789 2858091 SGTC_910 3454-3003 490 µM 1.00936641613295 0.150734597946595 no 531 0.156399469294444 809 820824 SGTC_1841 st054148 70 µM 1.00909826314247 0.150798677117166 no 532 0.156463755442858 730 675442 SGTC_1777 st045864 34.765 µM 1.00680733387432 0.151346868209479 no 533 0.157013684815425 813 4691462 SGTC_1356 1502-0781 85.8 µM 1.00534009311463 0.151698656175573 no 534 0.157366557805644 776 567702 SGTC_1257 0669-0121 16 µM 1.00529191417705 0.151710216841749 no 535 0.15737815372526 870 4307855 SGTC_613 3914-0030 117 µM 1.00485191394235 0.151815823176826 no 536 0.157484080913109 579 1145395 SGTC_2607 solasodine 47.35 µM 1.00478492449683 0.151831905883153 no 537 0.157500212294286 798 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2337 9009472 200 µM 1.004498752314 0.151900622335951 no 538 0.157569136161564 815 5742383 SGTC_3331 9141060 1.957 µM 1.00419728376244 0.151973034138712 no 539 0.157641765554427 757 4906567 YPR165W RHO1 SGTC_3208 9114115 49.47 µM 1.00072292095695 0.15280921992633 no 540 0.158480391452458 695 650895 SGTC_1835 st008666 49.2 µM 1.00059963683889 0.152838947050262 no 541 0.158510202873121 688 690455 SGTC_2138 5575593 77.673 µM 0.997905655612375 0.153489496025119 no 542 0.159162554635418 783 762213 SGTC_3005 9076496 71.4286 µM 0.997214552897524 0.153656680299425 no 543 0.159330189274751 791 21368410 SGTC_1910 st062352 60.4 µM 0.996437614301722 0.153844772992075 no 544 0.15951878235249 788 2245730 SGTC_20 0481-0013 4.944 µM 0.993946312006614 0.154448931360533 no 545 0.160124502941422 806 182045 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.991578931349809 0.155024489302031 no 546 0.160701485516432 891 688761 SGTC_1299 1079-1439 3.74 µM 0.983897402984447 0.156901765347892 no 547 0.162582980371749 778 323161 SGTC_53 0973-0023 39.979 µM 0.981515528206611 0.157486893131075 no 548 0.163169290359053 809 674768 SGTC_2693 st077581 40.7 µM 0.980840773942987 0.157652912580014 no 549 0.163335633830317 896 25238761 SGTC_1493 4348-0038 111 µM 0.978650135252011 0.15819269908331 no 550 0.163876439117287 880 800424 SGTC_1985 st071382 65.5 µM 0.977859104427953 0.158387911532439 no 551 0.164072006961907 832 6123237 SGTC_2002 4023503 131 µM 0.977593096435754 0.158453593103186 no 552 0.164137806555185 935 4736863 YCR052W RSC6 SGTC_1126 isoteolin 1.0172 µM 0.976170718139448 0.158805103882684 no 553 0.164489935679471 792 133323 SGTC_1904 st060225 78 µM 0.975758233113439 0.158907136386484 no 554 0.164592143484209 815 66595 SGTC_2101 5377231 179.231 µM 0.975468488312682 0.158978833489118 no 555 0.164663962644005 825 2844213 SGTC_2742 clothiapine 36.27 µM 0.973305183651303 0.159514811211376 no 556 0.165200823459134 781 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1066 ketoconazole 628 nM 0.972392841846535 0.159741206093879 no 557 0.165427575835697 874 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_3087 9117406 49.47 µM 0.972120760149068 0.159808763027779 no 558 0.165495237665198 788 42546093 SGTC_58 0957-0393 9 µM 0.970031573214175 0.160328123506302 no 559 0.166015377265976 969 6997992 SGTC_2127 5253358 187.912 µM 0.967984000471673 0.160838208042915 no 560 0.166526180141311 738 20612 SGTC_211 3455-0679 143.504 µM 0.967872604018998 0.160865989113407 no 561 0.166553999005304 854 748649 SGTC_2663 amphotericin b 100 µM 0.965388003442216 0.161486435701861 no 562 0.167175253970591 805 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_32 0928-0142 34.1 µM 0.964817837545922 0.161629035547452 no 563 0.167318029976066 834 2244242 SGTC_1419 3993-2473 62.6 µM 0.963704531661065 0.16190771253277 no 564 0.1675970408595 853 704026 SGTC_1470 k295-0292 231 µM 0.963217379690139 0.162029752297577 no 565 0.167719222536065 861 5045612 SGTC_3319 9138450 16.7555 µM 0.959801812942935 0.162887091445795 no 566 0.168577484862576 800 2029690 SGTC_1635 st007035 42.4 µM 0.959037478404635 0.163079349713395 no 567 0.168769932481515 950 3716403 SGTC_1217 1183-1422 255 µM 0.957408643727119 0.163489553452972 no 568 0.169180518665936 895 2849664 SGTC_1934 st074720 32.6 µM 0.957320475257875 0.163511776794382 no 569 0.16920276188997 875 17250992 SGTC_1337 1486-1011 40.3 µM 0.957181611093276 0.163546782238966 no 570 0.169237798478748 848 X1337 SGTC_1633 st005664 67.9 µM 0.957056834521029 0.16357824057652 no 571 0.169269284622852 851 2063822 SGTC_457 grayanotoxin iii 135 µM 0.95527387862856 0.164028183833106 no 572 0.169719606784152 876 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1979 st071809 45.3 µM 0.953794573264752 0.164402107293306 no 573 0.170093818443807 871 4976333 SGTC_3221 9128209 49.47 µM 0.951784958618743 0.164910961347988 no 574 0.17060302591883 809 16460723 SGTC_2280 7785178 200 µM 0.951757767725874 0.164917853333957 no 575 0.170609922385469 835 2954328 SGTC_2850 9015429 58.44 µM 0.95064404924292 0.165200304166067 no 576 0.170892549823792 796 6457570 SGTC_3252 9135871 49.47 µM 0.950588800889231 0.165214323881547 no 577 0.170906577948406 843 17682838 SGTC_2197 6588183 93.1375 µM 0.949372608176422 0.165523137634139 no 578 0.171215568383549 825 884136 SGTC_618 k072-0232 33.2 µM 0.947207136835206 0.166073914320919 no 579 0.171766619696777 827 5872756 YGL099W LSG1 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.946013930905662 0.166377905621002 no 580 0.172070740417824 897 165506 SGTC_1243 0416-0003 5.65 µM 0.943084845799102 0.167125666814196 no 581 0.172818753193539 827 2141977 SGTC_1288 0973-0013 65.5 µM 0.942259726812511 0.167336700603191 no 582 0.173029840863802 884 4315430 SGTC_2409 alverine citrate 63.97 µM 0.939328090842013 0.168087888997243 no 583 0.173781160168497 850 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_377 3970-0964 33.1 µM 0.938920023620968 0.168192621971946 no 584 0.173885903865673 950 16481235 SGTC_2979 9012552 45.46 µM 0.936758974460263 0.168747968305833 no 585 0.174441276380054 828 17100905 SGTC_1840 st055363 71 µM 0.935985124915419 0.168947118339037 no 586 0.174640423256324 808 676033 SGTC_81 0411-0046 9.971 µM 0.935655024271977 0.169032115594974 no 587 0.174725417152848 797 12925265 SGTC_960 1222-0186 7.7 µM 0.934986861063439 0.169204244254898 no 588 0.174897535326915 871 3126296 SGTC_2612 dictamnine 15.46 µM 0.930306182825227 0.170413209728759 no 589 0.176106288753554 826 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1065 prochlorperazine maleate 2.48 µM 0.928911741581085 0.170774444873737 no 590 0.176467413738345 899 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_998 3996-0085 177 µM 0.92888744062087 0.170780744468558 no 591 0.176473711221826 934 715391 SGTC_495 decylubiquinone 155 µM 0.928648090520136 0.17084279970169 no 592 0.176535745308684 817 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1279 0874-0590 65.2 µM 0.926856455507036 0.17130776707652 no 593 0.177000534153457 888 3523074 SGTC_1775 st081588 35.1725 µM 0.924037131435567 0.172041078118316 no 594 0.177733491844325 913 1426443 YGL099W LSG1 SGTC_344 k064-0035 6.43 µM 0.923535338421271 0.172171805098486 no 595 0.177864146636905 847 5088750 SGTC_2405 ticlatone 3.52 µM 0.920387916479101 0.172993215879586 no 596 0.178685040439094 918 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_597 k018-0003 82.8 µM 0.919654290873769 0.173185034912532 no 597 0.178876723037683 977 6786234 SGTC_1005 4092-0690 4.4 µM 0.917491076878954 0.173751432620241 no 598 0.179442683320408 837 1529343 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.913888800362388 0.174697233924341 no 599 0.180387639577774 860 6708514 SGTC_2383 9036125 200 µM 0.912856854132003 0.174968779341267 no 600 0.180658916008618 872 79580 SGTC_2774 tamoxifen 10.92 µM 0.91139999860557 0.175352590685577 no 601 0.181042327177706 888 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_3209 9113616 49.47 µM 0.905680088707679 0.176864668731687 no 602 0.182552602212554 945 16649353 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.900256775849787 0.178305927459719 no 603 0.183991808975553 882 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1284 0929-0043 16 µM 0.899325040313096 0.178554281383915 no 604 0.184239776710401 910 1239883 SGTC_1446 4239-0190 62 µM 0.898241544398137 0.178843360850085 no 605 0.184528394649898 938 1340085 SGTC_713 1488-1073 324 µM 0.896688777361715 0.179258156327729 no 606 0.184942505376202 924 3312542 SGTC_2506 ethyl hematommate 54.16 µM 0.894166819298194 0.179933142967221 no 607 0.185616321210963 826 3940691 An allergen. SGTC_2759 disulfiram 3.38 µM 0.892177664384372 0.180466652523912 no 608 0.186148856021717 876 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_976 1348-1067 47.6 µM 0.89127680673527 0.18070859692092 no 609 0.186390344069808 1006 5310671 YGL099W LSG1 SGTC_69 0096-0274 206.684 µM 0.88784353497032 0.181632538008372 no 610 0.187312460659296 984 6741392 SGTC_45 0kpi-0036 14.9 µM 0.887794774654746 0.18164568134013 no 611 0.187325577104703 864 2795021 SGTC_2836 9010338 19.48 µM 0.887480088233471 0.181730519305813 no 612 0.187410240895944 880 2994051 SGTC_3126 9127922 49.47 µM 0.887398361516486 0.18175255649532 no 613 0.18743223266478 898 45595682 SGTC_2032 5185112 25.99 µM 0.885638302284443 0.182227553056221 no 614 0.187906232419771 884 5718189 SGTC_68 0986-0284 82.829 µM 0.884377315418938 0.182568338884046 no 615 0.18824628218035 761 423278 YIL048W NEO1 SGTC_2777 climbazole 1.536 µM 0.884177940718376 0.182622256966906 no 616 0.188300082207743 945 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_3082 9117008 49.47 µM 0.883884596585058 0.182701605836922 no 617 0.18837925654805 931 41448529 SGTC_3147 9097027 49.47 µM 0.88376882096003 0.182732928783582 no 618 0.188410510339402 966 25236841 SGTC_921 1561-0023 372 µM 0.882550048877625 0.183062869389802 no 619 0.188739713576006 959 24050882 SGTC_1995 st072814 61.1 µM 0.882457820340965 0.183087852210486 no 620 0.188764639900667 888 5769371 SGTC_3044 9093193 49.47 µM 0.881277825014751 0.183407676431623 no 621 0.189083732640871 952 25236277 SGTC_2951 9072950 58.06 µM 0.879927403420777 0.183774119837819 no 622 0.189449319202606 1033 16488155 SGTC_978 1416-0512 87.4 µM 0.877405141570548 0.184459768170193 no 623 0.190133310732751 955 6814003 SGTC_2677 mitomycin C 100 µM 0.877402012373601 0.184460619794037 no 624 0.190134160255426 913 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_368 fentichlor 4.58 µM 0.877155726731697 0.18452765511749 no 625 0.190201029849589 862 7329 A pesticide. SGTC_1986 st071812 45 µM 0.875167166407167 0.185069466844249 no 626 0.19074147772201 905 11838594 SGTC_2107 5363541 170.161 µM 0.874182482081635 0.185338123656296 no 627 0.191009442230661 967 244052 SGTC_2171 5739187 198.077 µM 0.873006348923522 0.185659331651442 no 628 0.191329808586675 909 2262761 SGTC_2363 9053361 176 µM 0.871599530396555 0.186043994347072 no 629 0.191713443482396 960 6469797 YMR079W SEC14 SGTC_3227 9130768 49.47 µM 0.870550922539778 0.186331033577816 no 630 0.191999701665982 972 17720899 SGTC_1546 5-methoxyflavanone 78.7 µM 0.870098808146825 0.186454877096095 no 631 0.192123204488311 977 147795 SGTC_236 1509-0011 5.31 µM 0.869034439000177 0.186746631133525 no 632 0.192414147074951 1104 3107280 SGTC_2517 totarol 10 µM 0.867735961110078 0.187102939095719 no 633 0.192769447260543 891 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2274 7947094 46.08 µM 0.867375606160668 0.187201896547691 no 634 0.192868121554164 1027 2971028 SGTC_2478 5763493 32.33 µM 0.867188763331382 0.187253218392578 no 635 0.192919295987109 961 1365576 YLR208W SEC13 SGTC_2303 7774051 200 µM 0.866282601703063 0.18750224556469 no 636 0.193167602463337 913 2953184 SGTC_203 k066-0004 30.888 µM 0.866246022729352 0.187512302325839 no 637 0.193177629931303 1081 6795412 SGTC_1476 4112-3294 3.34 µM 0.865213503575852 0.187796313237543 no 638 0.193460807547412 976 704369 SGTC_881 0833-0569 170 µM 0.865020425958811 0.187849451795226 no 639 0.193513788902132 908 5418700 SGTC_870 0573-2213 57.6 µM 0.864958665287079 0.187866451442729 no 640 0.193530738172587 973 3916321 SGTC_1475 4092-1048 11.7 µM 0.863408271228538 0.188293509176074 no 641 0.193956516697689 967 2881759 SGTC_2200 6600604 21.907 µM 0.862945768899499 0.188421021838488 no 642 0.194083642323002 967 2904777 SGTC_2468 5987765 72.9 µM 0.859035640076223 0.189501178189843 no 643 0.195160426651437 1007 26772094 SGTC_1330 1469-0054 61.8 µM 0.857923769442259 0.189809022118455 no 644 0.195467279061554 1013 7102664 SGTC_2928 9011484 9.79 µM 0.855895381556102 0.190371414098387 no 645 0.196027824901245 895 2994751 SGTC_701 4424-0219 185 µM 0.854754233605417 0.190688258792563 no 646 0.196343609773586 1029 2911779 SGTC_879 0831-1030 162 µM 0.854270230548166 0.190822742039586 no 647 0.196477638896311 966 1549252 SGTC_3036 9090181 49.47 µM 0.852589492988207 0.191290197123722 no 648 0.196943495640137 951 25236586 SGTC_111 0083-0039 52.457 µM 0.852514371917794 0.191311106542966 no 649 0.196964332846415 889 759313 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.852056340199179 0.191438626743873 no 650 0.197091411312221 1009 3256 An antibiotic and ribosome inhibitor. SGTC_981 1488-1094 54.9 µM 0.851408304215063 0.191619134811358 no 651 0.197271290188261 928 3449522 SGTC_1047 2043-3044 82 µM 0.850944736959159 0.191748323723275 no 652 0.197400025983941 1020 669592 SGTC_550 4123-0385 25.7 µM 0.850527396329494 0.191864675610193 no 653 0.197515967777245 954 5731123 SGTC_286 k060-0067 22.9 µM 0.850268325659961 0.19193692458669 no 654 0.197587961151089 943 5985051 SGTC_57 miconazole 162.5 nM 0.848825402021662 0.19233962808123 no 655 0.197989226587451 927 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2224 6650123 117.647 µM 0.845648624521388 0.193228049647444 no 656 0.198874395658138 957 2908370 SGTC_1186 1319-0216 26 µM 0.845647509336902 0.193228361960458 no 657 0.198874706808498 1030 4565136 SGTC_1964 st076914 61 µM 0.84492100148447 0.193431889608437 no 658 0.199077473905672 1027 24208661 SGTC_2936 9038235 15.59 µM 0.844147394413116 0.193648755594536 no 659 0.199293523187621 998 4749415 SGTC_523 1934-0222 13.7 µM 0.844141675173879 0.193650359426072 no 660 0.199295120954997 945 1361595 SGTC_86 0417-1630 471.922 µM 0.841283283550345 0.194452944188473 no 661 0.200094626592009 1089 3634867 SGTC_2685 mycophenolic acid 18.85 µM 0.833892370524067 0.196537545883358 no 662 0.202170818453213 988 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3304 9125678 46.087 µM 0.831093798183677 0.197330402401333 no 663 0.202960321495068 952 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1238 0333-0287 48.8 µM 0.830659475456259 0.197453622470023 no 664 0.203083012782347 993 7226 SGTC_3317 9138495 8.753 µM 0.829738573484623 0.197715041969739 no 665 0.203343303679141 1028 17020139 SGTC_3295 9122362 53.5725 µM 0.826908598510445 0.19851970439859 no 666 0.204144434718221 964 4730473 SGTC_1970 st070122 35.8 µM 0.825795795323762 0.198836654246543 no 667 0.204459969834077 1000 102928 SGTC_3352 9151559 45.5865 µM 0.825260223004772 0.198989305226064 no 668 0.20461193466921 983 17159339 SGTC_2163 5671233 125 µM 0.825178313793673 0.199012657544002 no 669 0.204635181748411 1046 701023 SGTC_3150 9097574 49.47 µM 0.82451476264896 0.199201896859246 no 670 0.204823565570632 994 17217476 SGTC_3275 9138069 49.47 µM 0.823788527534031 0.199409137304808 no 671 0.20502986369017 994 17617007 SGTC_1982 st072467 71.9 µM 0.822230850484555 0.199854077855625 no 672 0.205472761860453 1014 3163533 SGTC_591 4299-0174 154 µM 0.822092121175213 0.199893733937972 no 673 0.205512234640901 1000 5509088 SGTC_1401 3807-4679 7.6 µM 0.820493032729322 0.200351178488992 no 674 0.205967549741565 982 3291456 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.817352284679575 0.20125146779655 no 675 0.206863567698401 940 61125 An anti-inflammatory. SGTC_2820 7989630 71.43 µM 0.816581978568156 0.201472644370363 no 676 0.207083678660998 917 2984098 SGTC_2534 helenine 20.12 µM 0.815854570930674 0.201681637245453 no 677 0.207291658751342 992 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2996 9066192 71.4286 µM 0.814849598015275 0.201970591461435 no 678 0.207579203303465 1027 6472854 SGTC_2264 7948757 110.76 µM 0.81409913991376 0.202186527988778 no 679 0.207794079285109 1039 2971411 SGTC_2730 imipramine 71.33 µM 0.81380744515249 0.202270497391239 no 680 0.207877634644742 1091 3696 A tricyclic antidepressant. SGTC_771 0250-0039 27.3 µM 0.813103216214626 0.202473307874482 no 681 0.208079441317066 980 3005115 SGTC_1664 st014217 9.02 µM 0.812715148735712 0.202585119142322 no 682 0.208190696892318 1123 3982782 SGTC_1163 k060-0048 49.9 µM 0.811641977687017 0.202894516783891 no 683 0.208498548410456 1076 6809982 SGTC_1055 3448-0672 86 µM 0.811448744020052 0.202950256458125 no 684 0.208554008224996 973 748378 SGTC_3000 9075062 71.4286 µM 0.810072700840645 0.203347450627227 no 685 0.208949196526361 965 17057871 SGTC_866 0495-0101 262 µM 0.809871904674978 0.20340544909545 no 686 0.209006900393512 952 635694 SGTC_1138 3761-0006 1.03 µM 0.807936509112139 0.203964979447044 no 687 0.209563566391037 1039 12061087 SGTC_1866 st057638 64 µM 0.80782134970459 0.203998301361191 no 688 0.209596716453652 1011 688802 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.807269875424382 0.204157917979667 no 689 0.209755507903602 1053 688751 SGTC_1038 k292-0204 154 µM 0.804849596870793 0.204859313295074 no 690 0.210453238560205 973 4454212 SGTC_409 arachidonic acid 100 µM 0.804316312007082 0.205014051363884 no 691 0.210607159690798 1059 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1093 fluphenazine 7.97 µM 0.803763197145954 0.205174616686956 no 692 0.210766874085053 1094 6602611 An atypical antipsychotic. SGTC_661 1304-0007 33.6 µM 0.801904218688637 0.205714812291241 no 693 0.211304182808689 989 3117130 SGTC_1184 1269-1718 139 µM 0.800723691094915 0.206058296444002 no 694 0.211645812080896 1056 5403821 SGTC_192 3455-0609 60.9 µM 0.795985764532904 0.207440252447597 no 695 0.213020154804639 1041 3769639 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.79524832349101 0.207655840528693 no 696 0.213234533565243 1029 688667 SGTC_2344 7990960 76.95 µM 0.79435862577611 0.20791611638517 no 697 0.213493341683727 986 140813 SGTC_814 3342-0569 96 µM 0.790608660185491 0.20901526188831 no 698 0.214586195823389 1046 4346283 SGTC_914 3820-6779 408 µM 0.790333505788739 0.20909604642688 no 699 0.214666512042495 1077 2893481 SGTC_2948 9070189 9.45 µM 0.789650262739062 0.209296724110888 no 700 0.214866022873018 966 6473636 YDL196W YDL196W SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.788870375902201 0.209525925863099 no 701 0.215093885824816 1227 16725076 SGTC_1512 0259-0544 12.2 µM 0.788390606792563 0.209666999030224 no 702 0.215234131737908 1080 18476 SGTC_1870 st057514 26.5 µM 0.785961244750354 0.210382195072839 no 703 0.215945096147702 1065 5393161 SGTC_3131 9127911 49.47 µM 0.784687877072047 0.21075764165174 no 704 0.21631829615666 1035 45595681 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.784364138876915 0.21085315698634 no 705 0.216413237198427 1057 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_3330 9141424 71.43 µM 0.784305171123129 0.210870557495359 no 706 0.216430532965431 1084 27261020 SGTC_2221 6807166 181.081 µM 0.783273899905676 0.211175006440082 no 707 0.216733143297067 1020 674925 SGTC_600 1495-0418 41.6 µM 0.781670558101275 0.211648851608202 no 708 0.217204104344384 1052 5377768 SGTC_2243 6634756 200 µM 0.781118759842451 0.211812071677778 no 709 0.217366324623891 1032 885676 SGTC_970 1315-0089 19.5 µM 0.780526588193613 0.211987315963247 no 710 0.217540491862175 1044 6811083 YLR033W RSC58 SGTC_2644 guaiazulene 100 µM 0.779952539986735 0.212157277808039 no 711 0.217709405564883 1090 3515 A coloring agent. SGTC_355 1311-2252 105 µM 0.777902576731239 0.212764872401579 no 712 0.218313224559461 1032 5338538 SGTC_1444 4112-3581 28 µM 0.776474978754929 0.213188601730494 no 713 0.218734294440917 1075 2877249 SGTC_3162 9099653 49.47 µM 0.77581866632674 0.213383568671569 no 714 0.218928030449651 1061 25237511 SGTC_800 3448-7362 155 µM 0.775187112366816 0.213571278853042 no 715 0.219114551197207 1202 15991913 SGTC_2018 5133068 143 µM 0.772441007342287 0.214388592894388 no 716 0.219926637056876 1034 785362 SGTC_1298 1079-1278 263 µM 0.772032721357613 0.214510264818853 no 717 0.220047523842107 1114 2840950 SGTC_1319 1306-0155 43.7 µM 0.771078582513018 0.214794760988969 no 718 0.220330177292316 1104 3122360 SGTC_2673 kobusone 100 µM 0.770327477565963 0.215018872543471 no 719 0.220552830460717 1128 6710676 An epoxy ketone and protein crosslinker. SGTC_2508 celastrol 40.54 µM 0.770036567258238 0.215105709610835 no 720 0.220639100838342 1064 122724 Celastrol is a natural product and antioxidant. SGTC_3120 9124077 49.47 µM 0.769425498207906 0.215288180723614 no 721 0.220820378245438 1168 18774327 YGL155W CDC43 SGTC_1120 ficusin 1.78878 µM 0.768913981013071 0.215440993734267 no 722 0.220972188530924 1090 6199 A DNA cross-linker. SGTC_627 1391-0720 175 µM 0.766832773168007 0.216063391836266 no 723 0.22159047403409 1041 997839 SGTC_1049 3226-0134 66 µM 0.764844909296771 0.216658846157801 no 724 0.222181951001271 1133 5702385 SGTC_2 0422-0095 29 µM 0.763678860364313 0.217008571302922 no 725 0.222529320711827 1012 6790840 SGTC_3018 9082602 49.47 µM 0.76312199992099 0.217175701714333 no 726 0.222695320416782 1105 17332089 SGTC_1301 naphtanilide LB 4.81 µM 0.762756203607061 0.217285528540814 no 727 0.222804402437961 1141 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1879 gemcitabine 100 µM 0.760695294579087 0.217904895805531 no 728 0.223419542985486 1101 60750 A nucleoside analog which inhibits DNA replication. SGTC_1641 st009299 47.1 µM 0.758335946741093 0.218615201570764 no 729 0.224124946429141 1065 4046054 SGTC_171 k064-0041 9.68 µM 0.758278570518244 0.218632491853984 no 730 0.224142116649331 1020 53325 SGTC_37 0566-0070 1.56 µM 0.755656508470399 0.219423487949713 no 731 0.224927583099157 1123 1626686 SGTC_2443 5493264 126.67 µM 0.754803989012979 0.219681020821993 no 732 0.225183300037294 1103 5340055 SGTC_2488 5268135 45.7 µM 0.753737283127 0.220003500392004 no 733 0.225503494951637 1113 1270356 YLR208W SEC13 SGTC_1583 clindamycin 39.6 µM 0.751424907761677 0.220703494384314 no 734 0.226198488657655 1042 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2891 9063876 19.48 µM 0.746987892298025 0.222050217853202 no 735 0.227535434712728 1082 6472478 SGTC_2263 7948595 193.29 µM 0.746852115624591 0.222091502645705 no 736 0.227576416516149 1034 2971371 SGTC_885 0865-0106 16.8 µM 0.746655431700163 0.222151314907814 no 737 0.227635789473697 1128 2793380 SGTC_2211 7117706 200 µM 0.745501564782147 0.222502394951055 no 738 0.227984282771167 1081 822771 SGTC_3245 9134821 49.47 µM 0.743781538888808 0.223026323603872 no 739 0.228504325258932 1103 17014901 SGTC_2132 5317594 122.667 µM 0.743119969805785 0.223228027855582 no 740 0.228704525157168 1076 794577 SGTC_1315 1237-0019 3.69 µM 0.742354403009089 0.223461569279592 no 741 0.228936319068118 1130 825140 SGTC_1839 st053978 48 µM 0.742236182295362 0.223497645707995 no 742 0.22897212500264 1170 3788398 SGTC_818 4072-2707 53.5 µM 0.738700641274089 0.224578087291737 no 743 0.230044398149941 1110 882871 SGTC_2541 muurolladie-3-one 83.07 µM 0.738482172946206 0.224644947058985 no 744 0.230110748158125 1129 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_1372 2752-0194 270 µM 0.73805342857997 0.224776192251577 no 745 0.230240991250925 1090 823334 SGTC_1151 3909-8316 15.3 µM 0.738045984156768 0.224778471487075 no 746 0.230243253066791 1126 800431 SGTC_1644 st010134 20.9 µM 0.737791295417576 0.224856456625806 no 747 0.230320641836436 1116 3818134 SGTC_541 4513-1321 94 µM 0.737147645237192 0.225053609263257 no 748 0.230516283791629 1095 747515 SGTC_2112 5488546 200 µM 0.735070431853347 0.225690535781933 no 749 0.231148300405314 1133 600757 SGTC_2972 9093619 59.92 µM 0.734374080578439 0.22590428283747 no 750 0.231360389681253 1133 25236256 SGTC_1915 st067105 30.6 µM 0.733640440111264 0.226129599693419 no 751 0.231583953565598 1157 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_3311 9131146 2.8755 µM 0.731917738911631 0.226659177426075 no 752 0.232109389156398 1092 4900406 YPR165W RHO1 SGTC_1044 1222-0021 1.78 µM 0.727104563508591 0.228142505532386 no 753 0.233580951696359 1085 4306703 SGTC_121 0557-0495 61.343 µM 0.723216087131063 0.229344834610604 no 754 0.234773568423696 1292 3104427 SGTC_1286 0929-0070 131 µM 0.723083986643805 0.22938574278428 no 755 0.234814143393881 1187 1420408 SGTC_1390 3413-2614 145 µM 0.722603619906355 0.229534534663522 no 756 0.234961721818788 1190 3421432 SGTC_3266 9136860 49.47 µM 0.722197968300122 0.229660225901729 no 757 0.2350863861392 1114 4871271 YPR165W RHO1 SGTC_1559 coumarin 343 70.1 µM 0.720209412118361 0.230276937862195 no 758 0.235698034855004 1155 108770 A hepatotoxic, DNA x-linker. SGTC_525 k781-2675 26.7 µM 0.719786613705006 0.230408179843153 no 759 0.235828194065232 1209 3651118 YDL195W SEC31 SGTC_1020 4335-0961 93.3 µM 0.71893837325469 0.230671610482624 no 760 0.236089445788452 1072 669075 SGTC_2079 5212404 121 µM 0.718126877735281 0.230923786983993 no 761 0.236339529511038 1163 758462 SGTC_2733 amorolfine 100 µM 0.716975263824798 0.231281921130672 no 762 0.236694679892074 1157 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3212 9128307 49.47 µM 0.716880009297262 0.231311557684966 no 763 0.236724068919699 1096 27243542 SGTC_1681 tripelennamine 100 µM 0.716782608932334 0.231341864064162 no 764 0.236754122081128 1171 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2761 levamisole 97.89 µM 0.716171156562734 0.231532169655265 no 765 0.236942835386096 1144 26879 An alkaline phosphatase inhibitor. SGTC_2367 9070478 135.38 µM 0.713924253533982 0.232232234328917 no 766 0.237637009538525 1139 572802 SGTC_2697 mebhydrolin 72.4 µM 0.713439475939028 0.232383430190232 no 767 0.237786926384261 1161 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_55 0767-0285 6.563 µM 0.712138258318335 0.23278953374002 no 768 0.23818958261962 1151 3116166 SGTC_1090 efavirenz 20.7 µM 0.709803296473431 0.233519251457896 no 769 0.238913062300181 1183 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_642 0335-0876 158 µM 0.708723398401203 0.233857167665767 no 770 0.239248070876596 1187 6812350 SGTC_2395 5646831 180.19 µM 0.705715452980908 0.234799825601618 no 771 0.24018255455428 1178 6808628 SGTC_848 0368-0089 85.6 µM 0.705557338258129 0.234849435105613 no 772 0.240231731305121 1167 762535 SGTC_3351 9150312 21.596 µM 0.705271128792918 0.234939249885901 no 773 0.240320761963203 1170 4904905 SGTC_1256 0570-0116 285 µM 0.705140039745101 0.234980392996341 no 774 0.240361545596449 1187 410638 SGTC_1953 st076800 12.1 µM 0.70346264261794 0.235507205715467 no 775 0.240883739906447 1160 297591 SGTC_614 0462-0418 107 µM 0.701708252543996 0.236058895795768 no 776 0.241430562697934 1081 5188303 SGTC_1671 st016596 74.5 µM 0.700293853776919 0.236504189259178 no 777 0.241871904663168 1236 2829167 SGTC_646 4092-0839 27.3 µM 0.700113960595445 0.236560857930983 no 778 0.241928068998272 1216 877796 SGTC_2563 tomatine 8.54 µM 0.699475538661121 0.23676202936778 no 779 0.242127447396171 1192 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1341 1486-1360 280 µM 0.698764647225339 0.236986147143318 no 780 0.242349562721335 1189 3976547 SGTC_2926 9010726 65.15 µM 0.697903572561671 0.23725776822165 no 781 0.242618750017206 1187 2994293 SGTC_1587 estradiol valerate 56.1 µM 0.697626570307456 0.237345183335565 no 782 0.242705380267213 1199 13791 A steroid. SGTC_432 NS 1619 61.3 µM 0.695451423244599 0.238032220690085 no 783 0.243386221836341 1190 4552 A K+/calcium channel activator. SGTC_2159 5658611 73.75 µM 0.694429429706626 0.238355401432461 no 784 0.243706471469067 1217 793844 SGTC_829 1635-0120 117 µM 0.693714372551073 0.238581663776174 no 785 0.243930675397194 1217 285054 SGTC_1581 himbacine 57.9 µM 0.693351421555498 0.238696555702925 no 786 0.244044520109954 1198 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2993 9054257 71.4286 µM 0.692206676146167 0.239059122433419 no 787 0.244403773361006 1212 6470217 YGL055W OLE1 SGTC_2970 9090938 41.86 µM 0.690523770885964 0.239592682700373 no 788 0.244932433290343 1221 17217104 SGTC_2602 kawain 100 µM 0.689878656808999 0.239797386484522 no 789 0.245135249412138 1198 5369129 SGTC_2645 abamectin 100 µM 0.689201388775346 0.240012395801861 no 790 0.24534827149668 1198 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_463 ikarugamyin 104 µM 0.68773412823391 0.240478560913467 no 791 0.245810112118088 1239 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1889 st059080 5.18 µM 0.68683388074192 0.240764823518281 no 792 0.246093708351772 1214 176925 Isolated from Daphnopsis sellowiana. SGTC_1199 1638-0010 4.46 µM 0.686163029005333 0.240978262892731 no 793 0.24630515433053 1196 3111136 SGTC_2051 5263410 176 µM 0.6859603909397 0.241042754808681 no 794 0.246369043035885 1272 227584 SGTC_2512 diallyl trisulfide 49.23 µM 0.685427013033187 0.241212553371644 no 795 0.246537251442275 1222 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_3089 9117425 49.47 µM 0.685322561229704 0.241245812764661 no 796 0.246570199025827 1166 9401657 SGTC_2595 hexamethylquercetagetin 100 µM 0.684515513062321 0.241502875884494 no 797 0.246824848442372 1142 386331 SGTC_2106 5357045 167.29 µM 0.683797393611515 0.241731738214147 no 798 0.247051556330029 1219 668842 SGTC_3229 9132204 49.47 µM 0.683490187244 0.241829679821359 no 799 0.247148574354182 1216 17682924 SGTC_3021 9087658 49.47 µM 0.682804739541849 0.24204828755775 no 800 0.247365117200545 1201 25237042 SGTC_1399 3562-5772 25 µM 0.682254734177997 0.242223776550247 no 801 0.247538945159744 1169 23847490 SGTC_733 4069-0007 56.1 µM 0.681275370749163 0.242536430530746 no 802 0.247848632265107 1244 5717425 YNL287W SEC21 SGTC_573 3702-0553 84.7 µM 0.680138804158809 0.242899544203468 no 803 0.248208288115294 1203 1222756 SGTC_1632 st005650 90 µM 0.679203506915549 0.243198576227323 no 804 0.248504462788762 1215 2759605 SGTC_135 0933-0004 26.348 µM 0.676622052533175 0.244024947186762 no 805 0.249322891815331 1194 21230617 YGL099W LSG1 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.676509747039869 0.24406093258651 no 806 0.249358529852776 1265 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_194 1486-1323 56.904 µM 0.675961105802593 0.244236771663704 no 807 0.249532669757782 1205 5178754 SGTC_2709 st078560 56 µM 0.674854978708879 0.244591492068888 no 808 0.249883953231772 1245 17250903 SGTC_2290 7904846 200 µM 0.673998684367964 0.244866284825884 no 809 0.250156075055624 1252 2962154 SGTC_820 1582-0060 59.9 µM 0.673279420650875 0.245097231524367 no 810 0.250384771314372 1217 3848840 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.672919775471851 0.245212753070334 no 811 0.250499165226398 1173 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_693 4161-2696 114 µM 0.672791067859753 0.245254102325251 no 812 0.250540110546319 1246 805759 SGTC_761 k216-0224 480 µM 0.672582240551308 0.245321199211146 no 813 0.250606551619247 1277 1340404 SGTC_3348 9149464 3.537 µM 0.672448869843697 0.245364056811118 no 814 0.250648990095377 1234 1951442 SGTC_486 niguldipine 82 µM 0.671201571762129 0.245765060699598 no 815 0.251046063762764 1235 1236 A calcium channel blocker. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.670740135101352 0.245913500792867 no 816 0.251193045055288 1236 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_79 0052-0007 94.094 µM 0.670675762578657 0.245934212687781 no 817 0.251213553233961 1282 2801472 SGTC_1932 st074806 40.9 µM 0.670037880479699 0.246139502195305 no 818 0.251416821332826 1335 17251235 SGTC_1616 st002734 56.1 µM 0.669350187353509 0.246360925287977 no 819 0.251636059598016 1210 4026101 SGTC_2335 9018011 154.17 µM 0.667717067727563 0.246887183876306 no 820 0.252157106544115 1268 6458208 SGTC_2586 curcumin 80 µM 0.667284283115124 0.247026745733939 no 821 0.252295281829073 1256 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1996 st072960 66.8 µM 0.667147490152837 0.247070866707983 no 822 0.252338964064403 1238 1719405 SGTC_490 phenamil 164 µM 0.665850785326029 0.24748931302296 no 823 0.252753240079363 1181 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1510 1123-0200 71.5 µM 0.665836387696517 0.247493961258997 no 824 0.252757841896254 1314 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1922 5578187 25 µM 0.664562278749415 0.247905488567062 no 825 0.253165251346857 1289 1350412 SGTC_1158 4092-0494 91.8 µM 0.664521389362463 0.247918701567651 no 826 0.253178331866637 1320 1148199 SGTC_530 4358-1714 28 µM 0.663445101503929 0.248266628443339 no 827 0.25352276424989 1267 1564641 SGTC_617 3770-0098 35 µM 0.663392838057616 0.248283530044876 no 828 0.253539495802346 1217 5962639 SGTC_1295 1013-0063 9.78 µM 0.663384205965613 0.248286321656889 no 829 0.253542259324994 1249 6826038 SGTC_2070 5230947 200 µM 0.662667880458333 0.248518039087067 no 830 0.253771642617457 1310 2835538 SGTC_1482 3346-2049 8.48 µM 0.661854118575945 0.248781415033719 no 831 0.254032359331484 1248 3826804 SGTC_2373 9071805 200 µM 0.66165567577253 0.248845664045416 no 832 0.254095958640675 1261 10149009 SGTC_2704 st078022 71.1 µM 0.661057724219679 0.249039313759086 no 833 0.254287647752695 1271 54697681 SGTC_700 3453-2283 142 µM 0.659750340806113 0.249462995806524 no 834 0.254707027869248 1316 565664 SGTC_1626 st003712 1.76 µM 0.658669005682721 0.249813711895683 no 835 0.255054170079769 1236 24207035 SGTC_2400 5203494 178.7 µM 0.658097302106931 0.249999241773034 no 836 0.255237804677885 1225 6777674 SGTC_3336 9143619 71.43 µM 0.657795134905527 0.250097330934092 no 837 0.255334890501088 1268 45595730 SGTC_1198 1612-1005 86.7 µM 0.656097424633957 0.250648819022739 no 838 0.255880720687987 1317 6998509 SGTC_527 4476-4215 268 µM 0.655640718186439 0.250797286459975 no 839 0.25602766007671 1250 4418754 SGTC_1851 st056236 18.9 µM 0.655337321601966 0.250895941222299 no 840 0.256125298329051 1265 5393171 SGTC_323 4013-0906 34.3 µM 0.655173373968613 0.250949260240895 no 841 0.25617806758507 1281 2910086 SGTC_933 2914-0560 114 µM 0.654943898250902 0.251023900360523 no 842 0.256251937657784 1279 463887 SGTC_412 gemfibrozil 100 µM 0.654649750384755 0.251119593158056 no 843 0.256346642450763 1243 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1808 st050063 61.5 µM 0.654528376610887 0.251159084350532 no 844 0.256385725657127 1265 4011993 SGTC_2932 9016711 44.54 µM 0.653983926390576 0.251336271663339 no 845 0.256561080644625 1254 7117328 SGTC_2995 9067767 71.4286 µM 0.65360461077668 0.251459756181343 no 846 0.256683286456191 1258 11673567 SGTC_2532 xanthone 78.9 µM 0.653531407990572 0.251483590714397 no 847 0.256706874014366 1206 7020 An insecticide. SGTC_1248 0469-0687 58.6 µM 0.652982141808067 0.251662467654607 no 848 0.256883895732498 1268 4017482 SGTC_1231 0242-0792 125 µM 0.652809415599978 0.251718732473941 no 849 0.256939576385615 1254 3707635 SGTC_1852 st056254 31.4 µM 0.65272792717868 0.251745279282751 no 850 0.256965847471481 1210 442583 SGTC_1097 itavastatin 7.23 µM 0.652467781716612 0.25183003780222 no 851 0.257049725225489 1283 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2229 7354935 190 µM 0.651375484198124 0.252186085828623 no 852 0.257402066100694 1211 318112 SGTC_2915 7971052 15.16 µM 0.651373957545887 0.25218658364572 no 853 0.257402558726312 1144 5741558 SGTC_1734 st037168 69.4 µM 0.650845857280363 0.252358819864544 no 854 0.257572997403398 1257 708907 SGTC_1169 aniline yellow 25.8 µM 0.647644527084598 0.253404237213794 no 855 0.258607445422517 1244 6051 A DNA damaging agent. SGTC_1438 4092-1045 4 µM 0.647310246573404 0.253513530009074 no 856 0.258715585616227 1255 1351342 SGTC_1375 2910-0797 186 µM 0.647075383926318 0.253590333009284 no 857 0.258791577995169 1266 742508 SGTC_1463 k081-0032 34.1 µM 0.646737053447501 0.253700992756361 no 858 0.258901068825219 1157 977755 SGTC_2655 perillic acid 100 µM 0.646088925113192 0.253913050714356 no 859 0.25911088363926 1257 5702197 An apoptosis inducer. SGTC_2001 4023502 57.655 µM 0.645984279070345 0.253947298064483 no 860 0.259144768334882 1291 108941 YCR052W RSC6 SGTC_1954 st077032 68.9 µM 0.643800114780973 0.254662659091432 no 861 0.259852529667448 1201 698907 SGTC_2629 bisabolol 100 µM 0.643037010848256 0.25491284066467 no 862 0.260100042385555 1291 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_1357 1503-1303 39.5 µM 0.642713859542412 0.255018823705258 no 863 0.260204893113949 1273 292895 SGTC_4 0960-0234 25.671 µM 0.641759320558078 0.255332015783123 no 864 0.260514733106356 1280 6821112 SGTC_2719 novobiocin 32.65 µM 0.641558079028493 0.255398070433129 no 865 0.260580079636926 1307 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_538 2922-0838 53.3 µM 0.640811683061762 0.255643142183893 no 866 0.260822520707565 1317 777039 SGTC_880 0833-0487 87.2 µM 0.639967037791795 0.255920621174551 no 867 0.261097014575907 1252 76075 SGTC_476 mead acid 10 µM 0.639819759536138 0.255969020437719 no 868 0.261144892445193 1308 5312531 An omega 9 fatty acid. SGTC_2206 7254556 146.969 µM 0.636418125343644 0.257088208780353 no 869 0.262251965062248 1270 4398905 SGTC_147 4466-0538 29.23 µM 0.636158125773338 0.257173857086971 no 870 0.262336681542443 1349 6742687 YHR072W ERG7 SGTC_2845 9003024 42.97 µM 0.635743654708148 0.25731042161585 no 871 0.262471758930725 1358 2990173 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.635573189520081 0.257366599315359 no 872 0.262527324388858 1240 2333 A French combination drug. SGTC_82 0054-0107 293.755 µM 0.635446872752457 0.257408231781577 no 873 0.262568502949469 1294 3104697 SGTC_1867 st057372 64 µM 0.634948866925623 0.257572402515415 no 874 0.262730882268075 1279 688837 SGTC_3075 9116269 49.47 µM 0.632953176557416 0.258230839488041 no 875 0.263382110219844 1315 17015205 YNL244C SUI1 SGTC_3307 9126885 69.2785 µM 0.63249648145528 0.258381639220096 no 876 0.263531253447345 1268 24824909 SGTC_500 h-89 112 µM 0.628953550209191 0.259553055517039 no 877 0.264689733155569 1376 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_274 sirtinol 40.1 µM 0.628107787354379 0.259833099036733 no 878 0.264966666004679 1275 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_3168 9103419 49.47 µM 0.628049888848488 0.259852275714692 no 879 0.264985629418464 1251 16649256 SGTC_1310 1188-0297 994 nM 0.626917840463376 0.260227370338901 no 880 0.265356546091018 1246 1588352 SGTC_3214 9129694 49.47 µM 0.624390323600016 0.261065847418909 no 881 0.266185639157558 1297 17158655 SGTC_1072 oxiconazole 14.9 nM 0.622627109536626 0.261651596390393 no 882 0.26676479605609 1318 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_3102 9121669 49.47 µM 0.620683693220017 0.26229798996029 no 883 0.267403880338152 1351 41905072 SGTC_2594 a-mangostin 100 µM 0.620582089814384 0.262331806433307 no 884 0.267437313421465 1341 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_9 0092-0002 10.449 µM 0.618102302121356 0.263157841283402 no 885 0.268253952439514 1307 759368 SGTC_1249 0481-0015 10.2 µM 0.617617491267299 0.263319490370004 no 886 0.268413755927135 1268 4227577 SGTC_2359 9039622 200 µM 0.614833871314471 0.264248605091917 no 887 0.269332219020417 1288 6463596 SGTC_3182 9108849 49.47 µM 0.614443246896207 0.264379120885209 no 888 0.269461232606194 1329 17133045 SGTC_1521 st012942 49.4 µM 0.614389026280626 0.26439723972079 no 889 0.269479142782672 1393 24207259 SGTC_1010 4112-3296 15.2 µM 0.613332481175563 0.264750430194122 no 890 0.269828260252169 1359 704384 SGTC_2868 9035608 32.47 µM 0.612681971188331 0.264968007212774 no 891 0.270043322858313 1307 6462614 SGTC_2027 5150920 200 µM 0.611085408818084 0.265502396624536 no 892 0.270571519506207 1303 786715 SGTC_992 3909-8734 162 µM 0.610851960934519 0.265580580347954 no 893 0.27064879516041 1323 4288319 SGTC_557 1315-0110 16.2 µM 0.610294196362827 0.265767427814889 no 894 0.270833470373135 1314 6833801 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.608645393958717 0.266320155156371 no 895 0.271379754471809 1373 804 An inhibitor of viral and cellular DNA polymerases. SGTC_205 1486-1330 71.903 µM 0.60818674932113 0.266474009759968 no 896 0.271531810962839 1332 4118834 SGTC_2682 pyrogallin 40.03 µM 0.607740464823875 0.26662376124033 no 897 0.27167981036328 1328 822798 An ATP competetive kinase inhibitor. SGTC_521 r062-0005 13.8 µM 0.607477344067686 0.266712071767314 no 898 0.271767086776921 1296 2832033 SGTC_370 0180-0345 38.7 µM 0.606859812152973 0.266919390431623 no 899 0.271971975161737 1296 3989527 SGTC_2217 6934799 96.0675 µM 0.606570290522919 0.267016617053986 no 900 0.272068060803671 1282 675606 SGTC_647 0140-0236 81 µM 0.606048656491561 0.267191836365409 no 901 0.272241221860101 1343 990837 SGTC_840 0245-0196 390 µM 0.605690122107518 0.267312303386227 no 902 0.272360272288483 1398 3827528 SGTC_1612 st002233 45.4 µM 0.602748924724291 0.268301574704533 no 903 0.273337864549747 1338 1035021 SGTC_2379 9035213 200 µM 0.602747149267326 0.268302172434956 no 904 0.273338455198777 1434 646551 SGTC_2842 9000675 19.48 µM 0.601967613328238 0.268564677930585 no 905 0.273597847874493 1277 2989072 SGTC_282 k297-0036 65.7 µM 0.601096892715884 0.268858042032829 no 906 0.273887726435402 1352 5061378 SGTC_3338 9144300 39.5675 µM 0.600540269462275 0.269045664404967 no 907 0.274073115858244 1346 4901274 SGTC_2198 6589944 200 µM 0.600531467090865 0.269048631969716 no 908 0.274076048081617 1310 5290268 SGTC_782 0083-0095 30.5 µM 0.596246435430517 0.270495202662476 no 909 0.275505304394185 1348 3591729 An indicator and reagent. SGTC_2890 9046729 58.44 µM 0.595676490542034 0.270687901018638 no 910 0.275695683255686 1288 903329 SGTC_1762 st045503 25.4615 µM 0.593633640319085 0.271379151331392 no 911 0.276378587950524 1357 4645554 SGTC_539 4859-0462 2.54 µM 0.593350030746824 0.271475187327883 no 912 0.276473461384744 1344 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_435 c-PAF 6.7 µM 0.593221414523462 0.271518744988097 no 913 0.276516491509646 1315 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1786 berberine 21.6 µM 0.592628960047051 0.271719432813825 no 914 0.276714746762337 1310 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.592044710774841 0.271917413492236 no 915 0.276910324458246 1390 279621 SGTC_2129 girgensonine 121.053 µM 0.588923824396051 0.272976181458813 no 916 0.277956187502854 1423 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2649 anisomycin 9.56 µM 0.58739035539393 0.273497162243866 no 917 0.278470784873874 1317 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1267 0828-0272 9.49 µM 0.586028538857032 0.273960238063993 no 918 0.278928168372665 1437 745334 SGTC_1346 1488-2224 62.4 µM 0.585031204837219 0.274299619911258 no 919 0.279263367432189 1363 3722427 SGTC_3217 9129673 49.47 µM 0.583822693554323 0.274711141040715 no 920 0.279669804268886 1345 17248312 SGTC_193 1273-0060 1.558 µM 0.583238496582971 0.274910180340355 no 921 0.279866379592748 1262 2847393 YHR072W ERG7 SGTC_3191 9110352 49.47 µM 0.582450675847469 0.275178707927958 no 922 0.280131577963504 1395 17122424 SGTC_1539 benzyladenosine 56 µM 0.582081051058548 0.275304738511223 no 923 0.280256044027732 1332 92208 A nucleotide analog. SGTC_440 fluspirilene 35.1 µM 0.58149467486893 0.275504732860688 no 924 0.28045355308522 1442 3396 An atypical antipsychotic. SGTC_1856 st057054 55.7 µM 0.581106950538834 0.275637012587335 no 925 0.280584187244988 1481 1266018 SGTC_638 3970-0837 4.09 µM 0.578948207144167 0.276374080469225 no 926 0.28131206048451 1358 4118451 YLR208W SEC13 SGTC_507 nimesulide 162 µM 0.57728142137247 0.27694383802117 no 927 0.281874681012837 1420 4495 A COX2 inhibitor. SGTC_3244 9134489 49.47 µM 0.577233618375941 0.276960187003796 no 928 0.281890824822459 1321 16584271 SGTC_1916 st067606 49.2 µM 0.576262801153121 0.277292315963889 no 929 0.282218781135118 1435 19590279 SGTC_1455 4262-0120 131 µM 0.574566015164476 0.277873275429444 no 930 0.282792420928512 1446 1529587 SGTC_1050 3232-1156 69.3 µM 0.573486607644449 0.278243160760298 no 931 0.283157632162036 1353 700529 SGTC_2945 9067681 61.76 µM 0.57296760959031 0.27842109353282 no 932 0.283333312649693 1434 16456930 SGTC_681 1642-0006 26.6 µM 0.572006205337307 0.278750846817546 no 933 0.283658885351354 1365 4446530 SGTC_1266 0828-0227 32.9 µM 0.570980392172195 0.279102901304953 no 934 0.284006467157573 1398 3913820 SGTC_2309 7664088 163.95 µM 0.570917057167655 0.279124644679022 no 935 0.284027933976004 1402 704922 SGTC_3079 9117512 49.47 µM 0.570129604518783 0.279395051730827 no 936 0.284294898626456 1448 7185044 SGTC_1368 1852-0141 284 µM 0.568359971252922 0.280003198284895 no 937 0.284895282460446 1374 2838987 SGTC_1428 4049-0204 61.7 µM 0.567530971248582 0.280288310358842 no 938 0.285176745341779 1453 X1428 SGTC_767 0929-0023 86 µM 0.567330003846835 0.280357448817201 no 939 0.285244997939903 1416 1204563 SGTC_342 k048-0088 23.3 µM 0.565088088127342 0.281129290516398 no 940 0.286006925125298 1352 6820570 SGTC_39 0986-0283 58.349 µM 0.561641305756368 0.282317939210684 no 941 0.287180215851953 1473 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_991 3996-0057 64.7 µM 0.561157818279505 0.282484866669658 no 942 0.287344977873569 1402 715343 SGTC_586 0957-0265 8.15 µM 0.559354520864257 0.283107886098443 no 943 0.28795989656587 1332 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2038 4100038 30.985 µM 0.559244492931958 0.283145920872636 no 944 0.287997435842467 1414 3596803 SGTC_807 1315-0151 48 µM 0.559088367085929 0.283199895114552 no 945 0.288050706747228 1441 4011080 SGTC_1713 st033146 12.748 µM 0.558755906404908 0.28331484648811 no 946 0.288164159455932 1474 674619 SGTC_2057 5236571 38.335 µM 0.558710359804353 0.283330596391492 no 947 0.288179703943827 1457 54684039 YBR257W POP4 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.558638693621044 0.283355379232899 no 948 0.288204163521111 1439 5024745 SGTC_1172 0370-0043 85 µM 0.558092868787552 0.283544164699097 no 949 0.288390484968144 1444 376585 SGTC_1174 0739-0097 51.1 µM 0.55590792911101 0.284300476830195 no 950 0.289136898744579 1413 728447 SGTC_2469 5655019 90.81 µM 0.554322751188453 0.284849785587461 no 951 0.289678991329596 1503 2788239 SGTC_2839 9003951 25.97 µM 0.554322317722255 0.284849935864923 no 952 0.289679139629789 1408 2990634 SGTC_3254 9136651 49.47 µM 0.554177719964674 0.284900068260599 no 953 0.289728612316138 1370 16454030 SGTC_3153 9100258 49.47 µM 0.552874707679434 0.285352015542912 no 954 0.290174603769308 1355 25236848 SGTC_2701 st077767 14.721 µM 0.55176639597907 0.285736699856285 no 955 0.290554206621735 1385 5721188 SGTC_1317 1273-0028 910 nM 0.551686842028611 0.285764321752352 no 956 0.290581463223249 1391 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1648 st011736 69.8 µM 0.551335013611207 0.28588649518582 no 957 0.290702020253089 1464 2855514 SGTC_2718 lomofungin 53.02 µM 0.551233296157244 0.285921821492492 no 958 0.290736878971209 1470 5351222 A RNA synthesis inhibitor. SGTC_2190 6049624 200 µM 0.551209477208312 0.28593009407465 no 959 0.290745042041797 1401 2265554 SGTC_2938 9059746 27.26 µM 0.547459401848826 0.287233953315227 no 960 0.292031577391875 1429 6471769 SGTC_844 0330-0132 15.3 µM 0.547298457153165 0.287289974904488 no 961 0.292086851822205 1437 2828079 SGTC_750 4073-0104 132 µM 0.547045500348143 0.287378034493186 no 962 0.292173736493398 1298 22330957 SGTC_438 sphingosine 6.67 µM 0.546312858605764 0.287633154526351 no 963 0.292425449409328 1274 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_670 4204-0025 119 µM 0.546059537543151 0.287721390721083 no 964 0.292512506097079 1484 719039 SGTC_698 k064-0052 127 µM 0.545646555471805 0.287865267076592 no 965 0.292654457940444 1480 5088751 SGTC_2139 5578692 56.4705 µM 0.545536954132171 0.287903456136714 no 966 0.292692135922081 1412 650991 YMR113W FOL3 SGTC_1534 6-azauridine 81.6 µM 0.544463173794986 0.288277726410267 no 967 0.293061391720511 1414 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2162 5663267 200 µM 0.544282729129338 0.288340643606302 no 968 0.293123464941999 1454 6456493 SGTC_1771 st048882 4.1505 µM 0.543812136277271 0.288504759723951 no 969 0.293285378231669 1354 4580403 SGTC_561 1550-0330 72.9 µM 0.54284973827453 0.288840526599014 no 970 0.293616632172893 1374 6812934 SGTC_3033 9090887 49.47 µM 0.542164495014659 0.289079710206456 no 971 0.293852595964133 1383 19325384 SGTC_2799 7812892 81.82 µM 0.541685953579293 0.289246799930697 no 972 0.294017433900456 1476 20205235 SGTC_2194 5927483 104.545 µM 0.540906987235476 0.289518884444277 no 973 0.294285847307365 1440 760979 SGTC_1123 mangostin 811.285 nM 0.539233152222552 0.290103943152967 no 974 0.294862993863834 1434 5281650 An antioxidant. SGTC_2267 7931562 200 µM 0.539103054716181 0.290149439576822 no 975 0.294907873967125 1326 934880 SGTC_1824 st053723 68.6 µM 0.538799340402749 0.290255664578799 no 976 0.295012659400583 1384 675225 SGTC_1591 genipin 88.4 µM 0.537899063917698 0.29057064598963 no 977 0.295323367359713 1460 442424 A DNA cross-linking agent. SGTC_2291 7917025 104.35 µM 0.536002788203548 0.291234622206014 no 978 0.295978311731045 1371 2964612 SGTC_456 gingerol 170 µM 0.535294303855218 0.291482877858129 no 979 0.296223182289247 1483 442793 A herb. SGTC_351 caspofungin 25 nM 0.534849429352214 0.2916388140338 no 980 0.296376989930112 1524 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_783 0848-0141 92.7 µM 0.534692321432954 0.291693892355896 no 981 0.296431316013818 1421 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2865 9030313 51.95 µM 0.53409141390276 0.291904601050239 no 982 0.296639144922067 1377 42562754 SGTC_946 3434-1334 87.4 µM 0.531038857495496 0.292976075473513 no 983 0.297695926225773 1488 4047976 SGTC_2441 5730946 39.09 µM 0.530677630660258 0.293102989961486 no 984 0.29782109491467 1498 1774275 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.530100406567795 0.293305846464807 no 985 0.298021158605009 1464 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2778 tioconazole 65.09 nM 0.529152795589751 0.293639010743733 no 986 0.298349729729996 1390 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.528983447693772 0.293698569097384 no 987 0.298408466156163 1666 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1707 st032323 6.317 µM 0.528834788213427 0.293750856101931 no 988 0.298460031373485 1415 3132057 YMR211W DML1 SGTC_2415 st077333 57.7 µM 0.528247422794742 0.293957488330632 no 989 0.298663809289027 1651 2766255 SGTC_2136 5328288 199.296 µM 0.528041978977047 0.294029778304484 no 990 0.298735099972788 1411 262395 SGTC_2091 4-phenylthiadiazole 200 µM 0.527601253551561 0.294184885060694 no 991 0.298888061387055 1451 270010 SGTC_3195 9113082 49.47 µM 0.526471360426325 0.29458270672901 no 992 0.299280372869261 1442 17018038 SGTC_888 0916-0002 6.97 µM 0.525394382596761 0.294962128444426 no 993 0.299654528872255 1486 2802138 YIL048W NEO1 SGTC_687 k029-0044 34.9 µM 0.524697330240954 0.29520782152801 no 994 0.299896806768843 1533 5829338 SGTC_1931 st074438 57.1 µM 0.523056032462864 0.295786708680853 no 995 0.300467630541508 1413 2787313 SGTC_263 alizarin 107.927 µM 0.522439214558872 0.296004395632595 no 996 0.300682279247325 1474 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_3334 9142812 21.919 µM 0.522041037169433 0.296144959173366 no 997 0.300820879193105 1489 45283678 SGTC_2318 6029776 164 µM 0.521303107109445 0.29640554225368 no 998 0.301077818430174 1530 818325 SGTC_2119 5528445 120.635 µM 0.520800441520476 0.296583107241712 no 999 0.301252897745084 1511 791935 SGTC_678 1218-2179 85.9 µM 0.520580130257182 0.296660946836549 no 1000 0.301329646998426 1478 6820081 YOR116C RPO31 SGTC_1733 st037357 54.9 µM 0.520161919782591 0.296808733210812 no 1001 0.301475362090809 1380 1272339 YGL099W LSG1 SGTC_1 0258-0098 57.368 µM 0.511701077416738 0.299805817365452 no 1002 0.304430115980961 1431 6790032 YDR047W HEM12 SGTC_964 1287-0107 19.4 µM 0.511349941902443 0.299930495742488 no 1003 0.304553020098485 1564 51516812 YPR165W RHO1 SGTC_2086 5274770 176.623 µM 0.510879187559379 0.300097684220485 no 1004 0.304717827710228 1463 689278 SGTC_1705 st027868 56.3335 µM 0.509689623513789 0.300520345794116 no 1005 0.305134461863593 1540 292948 SGTC_2459 5811157 9.22 µM 0.509561938467393 0.300565729279743 no 1006 0.305179197432253 1426 2870684 YBR192W RIM2 SGTC_2519 cryptotanshinone 88.04 µM 0.509085483210582 0.300735104537329 no 1007 0.305346153374312 1523 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_428 3448-4153 16.5 µM 0.508664831670567 0.300884677899619 no 1008 0.305493588653369 1395 3834874 SGTC_54 0159-0055 9 µM 0.508297401940587 0.301015354337836 no 1009 0.305622395894104 1555 3319099 SGTC_2679 rapamycin 1 nM 0.506925849488302 0.301503373002366 no 1010 0.306103423750264 1459 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1933 st074711 15.9 µM 0.506338651081962 0.30171241566934 no 1011 0.306309467000818 1431 17250958 SGTC_2976 9009005 19.48 µM 0.503109957445018 0.302862993145817 no 1012 0.307443483143182 1636 2993148 SGTC_1791 st048313 56.1 µM 0.502319898225857 0.303144837585535 no 1013 0.307721257245462 1552 1204976 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.501667185773372 0.303377773611868 no 1014 0.307950825267818 1449 4330530 SGTC_2179 6298986 200 µM 0.501554397281968 0.303418032981719 no 1015 0.307990502164891 1570 738374 SGTC_1291 0993-0025 5.79 µM 0.500648093562681 0.303741620831866 no 1016 0.308309404435127 1568 4353356 SGTC_956 1185-0240 191 µM 0.500378005856888 0.303838083071606 no 1017 0.308404468549354 1483 1416193 SGTC_1548 st061468 90.8 µM 0.500331883100824 0.303854557250906 no 1018 0.308420703889938 1494 390799 SGTC_657 3534-0529 86.7 µM 0.500274474327834 0.303875063139355 no 1019 0.308440912463792 1560 1049549 SGTC_2980 9014342 25.29 µM 0.500199648129287 0.303901791299342 no 1020 0.308467253050738 1477 2996599 SGTC_760 0568-0725 82.9 µM 0.499474669138365 0.304160810409446 no 1021 0.308722513791154 1581 3916171 SGTC_76 0433-0009 400.328 µM 0.498787294717646 0.304406485029238 no 1022 0.308964619570536 1486 2841569 SGTC_947 3447-0010 211 µM 0.497393705135145 0.304904839001437 no 1023 0.309455721874131 1465 748350 SGTC_1017 4239-0030 168 µM 0.497000513858819 0.305045511527683 no 1024 0.309594344480806 1425 1149593 SGTC_2326 6164455 177.58 µM 0.496761481110226 0.305131044651474 no 1025 0.309678630555858 1488 2888790 SGTC_3269 9137823 49.47 µM 0.496668223288734 0.305164417998423 no 1026 0.309711517198478 1454 17682936 SGTC_692 k241-0027 77.8 µM 0.496393414716117 0.305262770717629 no 1027 0.309808435153203 1568 3600480 SGTC_1403 3909-7815 62.9 µM 0.493979955445395 0.306127140052974 no 1028 0.310660167845715 1527 6615483 SGTC_2967 9089538 49.85 µM 0.493720102396733 0.306220269738678 no 1029 0.310751933107392 1648 728216 SGTC_1802 st050112 57.9 µM 0.493088434295484 0.306446707794135 no 1030 0.31097505130567 1477 4662563 SGTC_707 0865-0008 204 µM 0.492625774271776 0.306612607365626 no 1031 0.311138516467761 1567 723043 SGTC_3321 9137793 26.8275 µM 0.489266954467738 0.307818191860349 no 1032 0.312326356557349 1491 4904192 SGTC_272 doxorubicin 8.13 µM 0.488644559886102 0.308041817112985 no 1033 0.312546680042954 1487 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_178 4092-0806 87.505 µM 0.488596745235436 0.308058999780678 no 1034 0.312563608879757 1475 2169044 SGTC_598 3937-0236 20.2 µM 0.485922125022742 0.30902082012517 no 1035 0.31351119045986 1541 1379313 SGTC_2965 9082772 38.63 µM 0.485307880667711 0.309241893898827 no 1036 0.313728983076593 1602 16459634 SGTC_1927 st060202 13.8 µM 0.483555739612678 0.309872889466072 no 1037 0.314350596291716 1534 688887 SGTC_1726 st035556 14.5795 µM 0.482907735384185 0.310106396210538 no 1038 0.314580624562796 1599 5919439 SGTC_2176 5809774 33.9695 µM 0.481887101020529 0.310474334628085 no 1039 0.314943074890203 1547 2870539 SGTC_1421 4029-0249 71.4 µM 0.481487300745337 0.310618514254662 no 1040 0.315085101622049 1612 2894095 SGTC_1396 3511-0007 98.6 µM 0.481362787913018 0.310663423151819 no 1041 0.315129339669067 1488 X1396 SGTC_1051 3253-3903 78 µM 0.479414414505201 0.311366523502089 no 1042 0.315821920458475 1474 5509239 SGTC_1619 st003326 88.7 µM 0.478947577618769 0.311535091096596 no 1043 0.315987961361767 1583 2849032 SGTC_1037 k284-1091 78.7 µM 0.477559142009717 0.312036667158386 no 1044 0.31648200863033 1493 3334711 SGTC_980 1473-0395 201 µM 0.477458300150528 0.312073110141837 no 1045 0.316517903978738 1474 768876 SGTC_2858 9025781 8.96 µM 0.476569770788079 0.312394292980127 no 1046 0.316834256745243 1535 4894980 YPL153C RAD53 SGTC_2299 7976368 114.88 µM 0.476246582581476 0.312511153427374 no 1047 0.316949358196525 1615 2979718 SGTC_2782 7736369 71.43 µM 0.473091435982318 0.313653000510374 no 1048 0.318073973215629 1532 2950836 YOL077C BRX1 SGTC_1313 1220-0047 237 µM 0.467036759085774 0.315849187281409 no 1049 0.320236789403323 1585 3528706 SGTC_1196 1588-0294 184 µM 0.466807342914326 0.315932531031365 no 1050 0.320318860923219 1487 6144269 SGTC_3335 9143315 29.6265 µM 0.466554928792762 0.31602424043272 no 1051 0.320409169903211 1511 4899691 SGTC_2930 9013230 14.89 µM 0.465368486572128 0.316455461058656 no 1052 0.320833798816258 1626 2995857 SGTC_2321 7390090 138.78 µM 0.464688869192251 0.316702585195434 no 1053 0.321077140260943 1457 649046 SGTC_1064 honokiol 6.76 µM 0.463206888297702 0.317241750372976 no 1054 0.321608039630448 1524 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2470 5664817 21.68 µM 0.462754268030522 0.317406497318554 no 1055 0.321770257363474 1551 2859561 SGTC_85 0868-0259 160.055 µM 0.460927806960674 0.318071668868505 no 1056 0.32242520043452 1572 83173 SGTC_2329 6138490 200 µM 0.458777513125053 0.318855528424515 no 1057 0.323196972195504 1559 720019 SGTC_1816 st051957 91.6 µM 0.45751568690334 0.319315887377631 no 1058 0.32365021482758 1546 674121 SGTC_3299 9121982 43.1275 µM 0.456713191124495 0.31960881133311 no 1059 0.323938604107941 1517 17594604 YPL160W CDC60 SGTC_2312 7706453 155.7 µM 0.455472547884186 0.320061887716462 no 1060 0.324384656461361 1531 976098 SGTC_619 1652-1634 108 µM 0.455006247427153 0.32023224764621 no 1061 0.324552372145421 1540 5400454 SGTC_3024 9090631 49.47 µM 0.453895415823596 0.320638235595929 no 1062 0.324952051596292 1596 25236383 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.450796444657578 0.321771984536735 no 1063 0.326068131994418 1534 689007 SGTC_560 2332-1943 155 µM 0.449508468179248 0.322243676118111 no 1064 0.326532450355049 1569 21177716 SGTC_2446 5162541 200 µM 0.443928685468776 0.324290442425646 no 1065 0.328547072224287 1515 1549321 SGTC_2943 9068529 45.32 µM 0.442261608190693 0.324902992024613 no 1066 0.329149954507077 1543 3270634 SGTC_2639 lactacystin 53 µM 0.441023540620079 0.325358213272927 no 1067 0.329597977415437 1651 3870 A proteasome inhibitor. SGTC_407 eburnamonine 100 µM 0.440324040154881 0.325615525745256 no 1068 0.329851215784342 1524 3195 SGTC_940 3232-1287 54.8 µM 0.44014662225005 0.325680802451654 no 1069 0.329915458342212 1571 1585493 YIL048W NEO1 SGTC_161 4065-0411 162.148 µM 0.438105446467283 0.326432188724684 no 1070 0.330654923211176 1633 1906281 YLR208W SEC13 SGTC_2771 fluoxetine 41.05 µM 0.437572370709787 0.326628537806563 no 1071 0.330848151735149 1615 3386 A selective serotonin reuptake inhibitor. SGTC_31 0508-1974 57.237 µM 0.437402939663229 0.326690954815481 no 1072 0.330909576296716 1612 6810525 SGTC_1661 st013063 9.66 µM 0.437291296660573 0.326732085834106 no 1073 0.3309500531999 1584 721395 SGTC_1349 flufenamic acid 69 µM 0.435839221437058 0.32726724458805 no 1074 0.331476692452436 1545 3371 A non-steroidal anti-inflammatory. SGTC_2643 anethole 100 µM 0.432300590073176 0.328572884500246 no 1075 0.332761479180032 1567 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2575 plumbagin 510 nM 0.431998440909433 0.328684465050642 no 1076 0.332871273157434 1508 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1425 4048-4433 7.33 µM 0.431602890972761 0.328830560623739 no 1077 0.333015028464153 1634 23734946 SGTC_868 0527-0199 213 µM 0.429489284606215 0.329611659763663 no 1078 0.333783595120026 1595 2849450 SGTC_2565 isoliquiritigenin 100 µM 0.428255825462323 0.330067837840784 no 1079 0.334232438224824 1493 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1945 st075991 56.6 µM 0.427089928551313 0.330499261359651 no 1080 0.334656914165011 1539 1084980 SGTC_1311 1190-0148 100 µM 0.426913304178695 0.330564638357844 no 1081 0.33472123744153 1684 1961333 SGTC_2072 5231554 129 µM 0.426645498932689 0.330663775553924 no 1082 0.334818776330323 1711 789545 SGTC_1224 0823-0416 294 µM 0.426082262516589 0.330872315381173 no 1083 0.335023952266968 1654 3598164 SGTC_266 formosanin C 406 nM 0.425221069612692 0.331191275893378 no 1084 0.335337763079589 1597 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1116 jasmonic acid  1.58368 µM 0.424000839166694 0.331643423101194 no 1085 0.335782600645319 1645 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_826 1683-5028 118 µM 0.423757830451439 0.33173349747458 no 1086 0.33587121748711 1590 722377 SGTC_3213 9129884 49.47 µM 0.423528568256784 0.331818485438724 no 1087 0.335954829816356 1461 17190742 SGTC_666 0272-0154 136 µM 0.42277154416747 0.332099177273881 no 1088 0.336230975492108 1603 6870312 SGTC_1030 k029-0042 36.7 µM 0.420602002855868 0.332904128381766 no 1089 0.337022865485646 1614 6080581 SGTC_2760 etidronate 98.04 µM 0.420513679726857 0.332936914700754 no 1090 0.337055119065091 1561 3305 A chelator and antioxidant. SGTC_2173 5763948 167 µM 0.415947173545499 0.334633776952354 no 1091 0.338724329641284 1615 2867177 SGTC_252 miconazole 1.30953 nM 0.415772883904283 0.334698608258304 no 1092 0.338788101385012 1609 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_99 0109-0120 622.8 µM 0.414823846472056 0.335051712436428 no 1093 0.339135430681566 1691 759414 SGTC_2898 9056270 58.44 µM 0.41393778917445 0.33538151552915 no 1094 0.339459833927162 1603 19154699 SGTC_1459 k035-0031 35.7 µM 0.413415402827989 0.335576014617428 no 1095 0.339651145761217 1499 3877128 YMR208W ERG12 SGTC_667 1498-1044 59 µM 0.413379086415967 0.335589537874982 no 1096 0.339664447338046 1641 6739982 SGTC_1145 3546-0597 10.2 µM 0.413174194396455 0.335665838155953 no 1097 0.339739496679319 1600 875334 SGTC_1362 1611-0397 101 µM 0.412663798634391 0.335855935240793 no 1098 0.3399264757778 1597 27816 SGTC_304 1310-0298 97 µM 0.410020125745113 0.336841243465235 no 1099 0.340895592048528 1587 1550234 SGTC_819 1013-0258 27.7 µM 0.409869816741986 0.336897298011971 no 1100 0.340950723878306 1590 5753198 SGTC_719 2810-4230 27.3 µM 0.40947740932469 0.33704365508657 no 1101 0.341094670976259 1641 721079 SGTC_2622 2-methoxyxanthone 59.94 µM 0.409437543489111 0.337058525317592 no 1102 0.341109296284368 1760 71034 A hepatoprotective. SGTC_1202 1988-0068 29.6 µM 0.409216987459399 0.337140798835085 no 1103 0.341190214489039 1547 2850480 SGTC_414 piperonyl butoxide 100 µM 0.408274201101872 0.337492572078658 no 1104 0.341536188844905 1570 5794 A potent inhibitor of cytochrome P450. SGTC_2984 9022109 38.96 µM 0.408048650132905 0.337576750917699 no 1105 0.341618979049319 1639 6459207 SGTC_3110 9122132 49.47 µM 0.407823729582781 0.337660702569302 no 1106 0.341701545441782 1704 918317 SGTC_2878 9043973 25.97 µM 0.407631088428291 0.337732612351471 no 1107 0.341772268368395 1701 6465167 SGTC_2939 9044578 71.43 µM 0.405734019315096 0.338441073182912 no 1108 0.34246902166238 1567 2653634 SGTC_1262 0737-0114 49.6 µM 0.404706109267946 0.338825185592593 no 1109 0.342846775484477 1697 765919 SGTC_1251 0490-5699 265 µM 0.403955565246323 0.339105756992589 no 1110 0.343122697435598 1757 3883818 SGTC_3310 9130229 44.1445 µM 0.403285737422286 0.339356230116484 no 1111 0.343369016409123 1701 7761258 SGTC_1992 st073643 23.3 µM 0.402965731763548 0.339475917003622 no 1112 0.343486717109346 1623 3161292 SGTC_298 1391-0729 10 µM 0.402780306860976 0.339545276092182 no 1113 0.343554924852401 1613 3237558 SGTC_1132 3456-3614 2.5 µM 0.401351408401854 0.340079944681022 no 1114 0.344080709669804 1829 3125502 SGTC_11 0438-0307 1.3 µM 0.400691701264919 0.340326904088726 no 1115 0.344323560724672 1719 4011476 SGTC_579 4491-1009 110 µM 0.398833958468322 0.341022712331826 no 1116 0.345007776730283 1799 1271041 SGTC_2226 7298446 200 µM 0.398200314000267 0.341260164551213 no 1117 0.345241267260389 1708 3283010 SGTC_1433 4060-0023 7.6 µM 0.397368435284773 0.341571998599095 no 1118 0.345547894220077 1673 3840627 SGTC_1244 0416-0015 52.5 µM 0.39701448260128 0.34170471241226 no 1119 0.345678390429089 1622 96201 SGTC_422 cantharidin 155 µM 0.39598232494785 0.342091829432201 no 1120 0.346059033698823 1554 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2785 7756463 72.73 µM 0.39403270453736 0.342823499195832 no 1121 0.346778446867445 1572 2201551 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.393587830815332 0.342990537869238 no 1122 0.346942683565404 1628 6857784 SGTC_3190 9110366 49.47 µM 0.392509476422441 0.343395559594636 no 1123 0.347340905411234 1758 17123768 SGTC_3283 9109332 35.8195 µM 0.391811802255101 0.343657696600418 no 1124 0.347598636989989 1586 17027281 SGTC_1609 st001574 46.4 µM 0.390022819911366 0.344330214030905 no 1125 0.348259836348582 1605 3960012 SGTC_644 1498-1197 63.3 µM 0.389120961928426 0.344669428954774 no 1126 0.348593333848812 1704 6741615 SGTC_977 1348-1378 135 µM 0.388974551077535 0.344724510113013 no 1127 0.348647486076105 1615 X977 SGTC_2885 9057732 51.95 µM 0.388626329922396 0.344855527454916 no 1128 0.348776293229697 1645 6471414 SGTC_280 3448-3607 3.04 µM 0.386966148196249 0.345480422269147 no 1129 0.349390634603262 1733 626179 SGTC_794 k038-0031 316 µM 0.386553907417773 0.34563565566868 no 1130 0.349543243343646 1627 6624242 SGTC_2156 5649887 115 µM 0.38604708315195 0.345826541004781 no 1131 0.349730899578149 1739 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3341 9147222 25.867 µM 0.385180175396279 0.346153135503403 no 1132 0.350051965055262 1670 1939759 SGTC_1558 st069300 45.6 µM 0.383696748931906 0.346712259572702 no 1133 0.350601611251987 1737 24208000 SGTC_2717 st081029 62.2815 µM 0.382598777864666 0.347126315343325 no 1134 0.351008638279923 1740 5292846 SGTC_1649 st011737 51.3 µM 0.381265413363764 0.347629385754582 no 1135 0.351503157524491 1643 1761035 SGTC_690 glyoxal 20.3 µM 0.379619491064084 0.348250752496391 no 1136 0.35211394515089 1632 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1073 triclabendazole 3.09 µM 0.37809698249554 0.348825891151797 no 1137 0.352679274923829 1686 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1567 st069303 68.4 µM 0.376964052272343 0.349254089376948 no 1138 0.35310015984436 1654 5581319 SGTC_3316 9136639 10.545 µM 0.376394739053882 0.349469337453224 no 1139 0.353311728281528 1725 4903665 SGTC_80 0159-0065 512.242 µM 0.375868376082452 0.349668389814526 no 1140 0.353507375868873 1730 1548079 SGTC_578 3460-0051 92 µM 0.375560763991128 0.34978473726206 no 1141 0.353621732314887 1777 2876744 SGTC_1789 tunicamycin 25 nM 0.374859434820722 0.350050052192346 no 1142 0.353882504582687 1739 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1009 4106-0057 9.87 µM 0.373704413634119 0.350487159706332 no 1143 0.354312120633945 1769 2928005 SGTC_518 1021-0119 62.6 µM 0.373004535651213 0.350752118721452 no 1144 0.354572534114354 1597 1097762 SGTC_709 3807-1509 243 µM 0.371453715245623 0.351339485091806 no 1145 0.355149811843302 1681 1886677 YPL242C IQG1 SGTC_3016 9080866 49.47 µM 0.370408856858303 0.351735420968651 no 1146 0.355538937788879 1624 17066299 SGTC_1561 5-methoxyflavone 52.9 µM 0.3691563930946 0.352210238243627 no 1147 0.356005578551568 1732 94525 SGTC_2525 harmine 47.85 µM 0.368765186247312 0.352358594612142 no 1148 0.356151377975784 1745 5280953 A monoamine oxidase inhibitor SGTC_1614 st002383 48.6 µM 0.368294000399 0.35253731103651 no 1149 0.356327012808728 1675 1947235 SGTC_3112 9123419 49.47 µM 0.367246896547581 0.352934584335913 no 1150 0.356717430539861 1698 17015854 SGTC_2300 7976697 71.57 µM 0.36624351273507 0.353315420658035 no 1151 0.357091687936576 1607 2236109 SGTC_1832 st054113 55 µM 0.365424508740302 0.35362638418502 no 1152 0.357397274516461 1779 1251267 SGTC_611 3453-1652 23.7 µM 0.362205400631314 0.354849576236262 no 1153 0.358599272030525 1768 1560575 SGTC_488 nitrendipine 139 µM 0.361998470475578 0.354928256626206 no 1154 0.35867658671337 1732 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1972 st070201 17.4 µM 0.360922585057957 0.355337436738755 no 1155 0.359078659773673 1791 2829099 SGTC_277 nystatin 15.5 µM 0.360457016364493 0.355514553295104 no 1156 0.359252697579033 1641 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_793 0488-0545 106 µM 0.35893097037495 0.356095326420747 no 1157 0.359823365146529 1638 292548 SGTC_330 1488-0319 80.1 µM 0.358561779243393 0.356235881126003 no 1158 0.359961471831056 1706 6846614 SGTC_2246 7293507 91.5585 µM 0.358543403378827 0.356242877509397 no 1159 0.359968346335648 1847 887656 SGTC_2035 5154463 94.595 µM 0.358356241560308 0.356314139815588 no 1160 0.360038367105502 1775 2769623 SGTC_1838 st055369 84.5 µM 0.35736371286887 0.356692131279504 no 1161 0.360409769267366 1651 676036 SGTC_398 bronopol 33.3 µM 0.356699418612853 0.356945197652901 no 1162 0.360658420412175 1719 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2315 7733312 200 µM 0.355312744597427 0.357473661154553 no 1163 0.361177654384818 1653 726316 SGTC_855 0428-0020 25 µM 0.354543145700622 0.357767074474072 no 1164 0.361465937774414 1693 6812414 SGTC_17 0960-0276 49.807 µM 0.354330187476942 0.35784828068846 no 1165 0.36154572351534 1711 6821114 SGTC_2016 5121758 140 µM 0.352212657142129 0.358656096650569 no 1166 0.362339392681063 1673 2795203 SGTC_1103 duloxetine 36.1 µM 0.351778001924144 0.358821991518263 no 1167 0.362502378666529 1801 60835 A selective serotonin reuptake inhibitor. SGTC_3134 9127454 49.47 µM 0.351076373064394 0.359089838409797 no 1168 0.362765526371178 1726 24262820 SGTC_2421 5690543 90.72 µM 0.351054478381483 0.359098197822701 no 1169 0.362773739071847 1717 3397993 SGTC_2900 5328528 85.29 µM 0.350960052280008 0.359134250580145 no 1170 0.362809159047675 1643 795359 SGTC_3056 9094900 49.47 µM 0.3484512859134 0.36009257927708 no 1171 0.363750646135019 1610 25236784 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.348281073459843 0.360157631016338 no 1172 0.36381455316379 1870 551469 SGTC_2859 9028643 45.46 µM 0.347772196056536 0.360352137757974 no 1173 0.364005636054687 1791 17151580 SGTC_2477 5967686 25.23 µM 0.347077003950342 0.360617917446133 no 1174 0.364266734557597 1650 776118 SGTC_2368 9071271 200 µM 0.34689127888945 0.360688933610716 no 1175 0.364336499378293 1646 27209959 SGTC_3140 9094243 49.47 µM 0.346641773063024 0.36078434535146 no 1176 0.364430229557441 1815 19291112 SGTC_3159 9100096 49.47 µM 0.346086158056943 0.360996845243747 no 1177 0.364638982837498 1652 25236875 SGTC_1605 st000082 49.1 µM 0.345236871738003 0.36132174524572 no 1178 0.364958150601631 1771 1114022 SGTC_326 k292-0812 17.5 µM 0.345026258752033 0.361402332102952 no 1179 0.365037314932224 1825 3579357 SGTC_688 0527-0193 473 µM 0.343260169564471 0.362078332573654 no 1180 0.365701371247985 1752 4007154 SGTC_2252 omeprazole 400 µM 0.343102113272801 0.362138852305382 no 1181 0.365760820679693 1792 4594 A proton pump inhibitor. SGTC_3189 9110682 49.47 µM 0.341426544033119 0.362780639197869 no 1182 0.366391247548387 1700 17122418 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.340344427348749 0.363195323303771 no 1183 0.366798581863559 1738 97141 SGTC_2514 salinomycin 42.74 µM 0.339925104224864 0.363356057660297 no 1184 0.366956465365615 1872 23682228 A polyether potassium ionophore. SGTC_3098 9119039 49.47 µM 0.338691405345843 0.3638290968441 no 1185 0.36742110797088 1716 17161528 SGTC_2062 5245942 200 µM 0.338439799878378 0.363925595852956 no 1186 0.367515892896692 1736 1376160 SGTC_2487 5918373 44.05 µM 0.338251104823251 0.363997972303976 no 1187 0.367586983480348 1823 2876279 SGTC_1392 3455-1037 33.9 µM 0.338213539971263 0.364012381372363 no 1188 0.367601136524572 1803 981132 SGTC_2223 6903751 107.57 µM 0.337923232353547 0.364123743606695 no 1189 0.367710519740438 1796 5598863 SGTC_3121 9125696 49.47 µM 0.336180002696606 0.364792688912007 no 1190 0.368367565887147 1792 1235365 SGTC_708 3448-5400 146 µM 0.335817619887144 0.364931801120333 no 1191 0.368504201141598 1767 3462195 SGTC_2250 alverine citrate 130 µM 0.335474148585905 0.365063669956826 no 1192 0.368633721223632 1698 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_125 0133-0007 11.75 µM 0.334417967046323 0.365469269360194 no 1193 0.369032091675786 1898 26541 SGTC_3337 9144342 33.5465 µM 0.334395731650579 0.365477809912035 no 1194 0.369040479934185 1792 17682949 SGTC_785 1270-0111 65.3 µM 0.334318806184187 0.365507357277922 no 1195 0.369069500393042 1712 6741994 SGTC_100 0086-0128 49.5915 µM 0.334268996222585 0.365526489900429 no 1196 0.369088291810675 1630 93297 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.333701772103238 0.365744391291911 no 1197 0.36930230611048 1690 16623 A steroid. SGTC_1193 1488-0126 41.5 µM 0.332881473164938 0.36605958899339 no 1198 0.369611877467621 1708 1384710 SGTC_487 nimodipine 119 µM 0.331269350487424 0.366679306146743 no 1199 0.370220520141874 1822 4497 L-type voltage-gated calcium channels inhibitor SGTC_2292 7671323 168.05 µM 0.330904102276612 0.366819759824497 no 1200 0.370358461603458 1715 937504 SGTC_2908 7930301 100 µM 0.329870813184235 0.367217200535147 no 1201 0.370748788965979 1663 2223178 SGTC_2449 5812982 45.77 µM 0.329692470129273 0.367285812198634 no 1202 0.370816171946437 1730 776185 SGTC_2764 methyldopa 94.69 µM 0.328927076443811 0.367580320507479 no 1203 0.371105403995717 1852 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1531 st059297 52.4 µM 0.328547405738102 0.367726439177563 no 1204 0.371248903515354 1767 7566702 SGTC_261 5-fluorouridine 15.376 µM 0.328093603076986 0.367901113117855 no 1205 0.371420445272476 1815 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2737 bleomycin 30.5 nM 0.324849965181803 0.369150420772605 no 1206 0.372647313381452 1742 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2220 6782180 200 µM 0.324755759050114 0.369186725595854 no 1207 0.372682965133396 1839 833803 SGTC_828 2074-0507 139 µM 0.324170820224704 0.36941217333943 no 1208 0.372904356164756 1843 X828 SGTC_1862 st057513 3.81 µM 0.324080001394226 0.369447180859493 no 1209 0.372938733568264 1711 5393163 SGTC_2077 5212015 200 µM 0.323130089680643 0.369813403812306 no 1210 0.373298361641531 1698 780900 SGTC_3097 9117246 49.47 µM 0.322040161446573 0.370233753341209 no 1211 0.373711134711097 1717 16423892 SGTC_281 1672-3440 14.9 µM 0.321558677830339 0.370419495160126 no 1212 0.373893526348505 1820 6833000 SGTC_974 1326-0144 138 µM 0.320931370244776 0.370661536778018 no 1213 0.374131200174997 1714 5411856 SGTC_1484 3473-2379 286 µM 0.320771138899118 0.37072336897474 no 1214 0.374191916182803 1780 671917 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.320403050717628 0.37086542436708 no 1215 0.374331406606578 1878 756377 SGTC_1785 bathophenanthroline 24 µM 0.319443672401778 0.371235757632616 no 1216 0.374695049178798 1691 72812 An iron chelator. SGTC_536 3852-0578 10.6 µM 0.318491560864663 0.371603403732979 no 1217 0.375056047551799 1858 2869208 SGTC_810 3825-7150 143 µM 0.317481330338746 0.371993619852975 no 1218 0.375439201769781 1926 22330411 YGL099W LSG1 SGTC_2244 6635614 200 µM 0.317371599568582 0.372036012871884 no 1219 0.375480827209319 1751 836499 SGTC_2366 9070441 60.58 µM 0.316328918895073 0.372438915971443 no 1220 0.375876431572608 1690 6837235 SGTC_497 capsazepine 133 µM 0.315947995641482 0.372586143691275 no 1221 0.376020990556887 1665 2733484 A calcium channel blocker. SGTC_2795 7780010 54.55 µM 0.31420432593947 0.373260313447976 no 1222 0.376682928661911 1769 953673 SGTC_2830 7992007 71.43 µM 0.313124914222373 0.37367785019627 no 1223 0.377092880687215 1685 1952075 SGTC_2666 tannic acid 100 µM 0.313122166251713 0.37367891335246 no 1224 0.377093924521754 1775 16134267 A thiamine antagonist. SGTC_3172 9105863 49.47 µM 0.311679442102305 0.37423721820681 no 1225 0.377642076528554 1801 2348785 SGTC_3069 9117009 49.47 µM 0.311636751733233 0.374253742534869 no 1226 0.377658300168397 1850 41904981 SGTC_2597 laccaic acid a 100 µM 0.310956210264632 0.374517193557496 no 1227 0.377916955771345 1758 5491415 A textile dye. SGTC_2037 5169046 200 µM 0.310904485529647 0.374537219619756 no 1228 0.377936617198937 1813 5718022 SGTC_160 3453-0671 289.699 µM 0.308096788450251 0.375624771089404 no 1229 0.379004342448291 1718 5322268 SGTC_2904 7225135 42.03 µM 0.30709062661922 0.376014745456086 no 1230 0.37938719605481 1870 4446116 SGTC_3263 9137018 49.47 µM 0.306143933741131 0.376381786135039 no 1231 0.379747529228143 1668 43844957 SGTC_2990 9074105 71.4286 µM 0.305045398131742 0.376807837635251 no 1232 0.380165788153314 1779 6502001 SGTC_1665 st014639 11.4 µM 0.303788576143866 0.377295462313116 no 1233 0.38064448530102 1828 981133 YIL048W NEO1 SGTC_1694 st024011 44.9 µM 0.303171229685632 0.377535053532049 no 1234 0.380879686617572 1791 2787533 SGTC_1268 0828-0275 2.46 µM 0.302815630668256 0.377673082368848 no 1235 0.381015185405215 1842 745337 SGTC_348 k064-0012 10.7 µM 0.302378901618417 0.377842623904148 no 1236 0.381181618248827 1733 5066323 SGTC_795 0685-0265 78 µM 0.302242144923301 0.377895718732215 no 1237 0.38123373930617 1757 302754 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.301538429099514 0.378168967920969 no 1238 0.381501975306328 1767 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1016 4226-1401 38 µM 0.301453083508561 0.37820211131622 no 1239 0.381534510435737 1756 2901613 SGTC_2180 6301957 200 µM 0.299815765701517 0.378838126113444 no 1240 0.382158844469092 1888 845462 SGTC_1225 1216-0074 20.6 µM 0.29953823091691 0.378945966860616 no 1241 0.382264703105736 1756 4241466 SGTC_3177 9107506 49.47 µM 0.299070987138836 0.379127543470064 no 1242 0.382442941324677 1870 8897194 SGTC_2817 7995342 71.43 µM 0.298944940163025 0.379176531426287 no 1243 0.382491028390849 1694 18879975 SGTC_1828 st055811 49 µM 0.298767465478798 0.379245509968644 no 1244 0.38255873825853 1919 5877589 SGTC_3164 9100705 49.47 µM 0.298438886939369 0.379373227730755 no 1245 0.382684106511325 1876 17174235 SGTC_3218 9131285 49.47 µM 0.298398522720526 0.379388918122905 no 1246 0.382699508217985 1907 17156417 SGTC_650 1328-0195 38 µM 0.297269684650027 0.379827800796765 no 1247 0.383130312105095 1891 2780821 SGTC_3146 9095609 49.47 µM 0.295717422846917 0.380431559777958 no 1248 0.383722945232636 1848 17173999 SGTC_589 1227-0070 34.1 µM 0.295647098344217 0.380458919709851 no 1249 0.383749800654976 1812 2841384 SGTC_139 0099-0334 718.624 µM 0.29534985007019 0.380574571533294 no 1250 0.383863319574899 1905 97690 SGTC_1522 st012842 45.6 µM 0.294123771527251 0.38105172055192 no 1251 0.384331663399725 1680 3491067 YOR116C RPO31 SGTC_3215 9129942 49.47 µM 0.287976250992488 0.383446845306435 no 1252 0.386682458958321 1954 17682944 SGTC_1028 k015-0029 4.8 µM 0.287657135740119 0.383571297822296 no 1253 0.386804602212277 1760 4588309 SGTC_512 prima-1 270 µM 0.286345323488609 0.38408302065792 no 1254 0.38730682378708 1885 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3279 9140807 49.47 µM 0.286304044267101 0.384099126491488 no 1255 0.387322630422523 1792 45595718 SGTC_3233 9132340 49.47 µM 0.285552373216963 0.384392439502164 no 1256 0.387610492874809 1760 17682950 SGTC_3353 9151644 39.2805 µM 0.277903832259729 0.387380748637759 no 1257 0.390543091010741 1826 4909158 SGTC_2416 tofa 880 nM 0.277634714294884 0.387486016658621 no 1258 0.39064639059938 1684 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3145 9085516 49.47 µM 0.277515597227501 0.387532613060481 no 1259 0.390692115556283 1742 25236195 SGTC_1410 3909-8106 77.9 µM 0.2766773533167 0.387860564411149 no 1260 0.391013931356421 1905 1039210 SGTC_1092 toremifene 6.32 µM 0.274692397012918 0.388637469789294 no 1261 0.391776286427407 1857 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_544 k015-0020 52.4 µM 0.27281591161823 0.389372329888948 no 1262 0.392497363838525 1805 3008304 SGTC_636 0kpi-0074 126 µM 0.272505784522872 0.389493818538534 no 1263 0.392616572056206 1827 616434 SGTC_2735 sertaconazole 140 nM 0.272258144119316 0.389590836516154 no 1264 0.392711768558969 1915 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2765 myclobutanil 7.74 µM 0.270929819332121 0.390111351065784 no 1265 0.393222504967252 1828 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3038 9091290 49.47 µM 0.270882551612486 0.390129876931492 no 1266 0.393240682638537 1918 25236843 SGTC_1646 st011709 75.6 µM 0.270009356572994 0.390472157323395 no 1267 0.393576527682238 1946 5757843 SGTC_3127 9126946 49.47 µM 0.269269819918712 0.390762111890825 no 1268 0.393861027478977 1752 27243249 SGTC_2102 5377816 72.7585 µM 0.268854282854214 0.390925060664631 no 1269 0.39402090948507 1944 1379702 SGTC_2566 crystal violet carbinol 226 nM 0.268426999799654 0.391092635485132 no 1270 0.394185329504436 1697 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1160 4092-0570 10.5 µM 0.26842423100749 0.391093721435146 no 1271 0.39418639500691 1766 4994975 SGTC_3099 9120367 49.47 µM 0.26777783931714 0.391347266416829 no 1272 0.394435164819124 1825 24824940 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.266920177515357 0.391683752656386 no 1273 0.394765310344602 1846 364106 SGTC_2222 6885208 172.143 µM 0.266914041460669 0.391686160305485 no 1274 0.394767672609998 1862 609514 SGTC_246 cycloheximide 667 µM 0.266273441997107 0.391937539857003 no 1275 0.395014312599033 1815 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1939 st074455 53.6 µM 0.26069248337121 0.394129478440018 no 1276 0.39716483154166 1986 1644229 SGTC_103 0844-0104 51.839 µM 0.260285138221556 0.394289596803794 no 1277 0.397321917806132 1935 5375804 SGTC_1872 amphotericin b 148 nM 0.260260400443377 0.394299321252642 no 1278 0.397331458078791 1934 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2357 9067248 200 µM 0.260194669116979 0.3943251606322 no 1279 0.397356808057832 1863 9150235 SGTC_1865 st057639 52.2 µM 0.259957488930794 0.394418401454985 no 1280 0.397448282701245 1912 688818 SGTC_1812 st052057 4.327 µM 0.259735448858496 0.394505695844298 no 1281 0.397533923281791 1814 3645418 SGTC_3109 9122853 49.47 µM 0.259665073287415 0.39453336489518 no 1282 0.397561068083299 1908 1234709 SGTC_2164 5685496 200 µM 0.259637373677521 0.394544255495061 no 1283 0.397571752330342 1932 759046 SGTC_1747 st037496 66.6 µM 0.259627088447086 0.394548299339399 no 1284 0.397575719551728 1831 723305 SGTC_345 1362-0200 395 µM 0.259155488286296 0.394733730587156 no 1285 0.397757636644218 1778 1419823 SGTC_1683 st010134 710 nM 0.256355773220432 0.395835056800857 no 1286 0.398838067421122 1769 3818134 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.255498836577376 0.396172317405708 no 1287 0.399168921038045 1964 6728940 SGTC_894 0960-0238 55.9 µM 0.255112111743695 0.396324544383799 no 1288 0.399318254892659 1964 6741907 YDL195W SEC31 SGTC_805 3852-0218 479 µM 0.254747361608383 0.396468135920229 no 1289 0.399459116716152 1797 6615355 SGTC_3015 9080845 49.47 µM 0.252686946510198 0.397279524700735 no 1290 0.400255067894015 1955 5296973 SGTC_1634 st006576 41 µM 0.251409232780807 0.397782910344607 no 1291 0.40074886508794 2003 3915356 SGTC_1780 st038448 24.544 µM 0.249928543850909 0.398366475788404 no 1292 0.401321304378447 1940 728868 YDL195W SEC31 SGTC_1787 fluconazole 80 µM 0.249456522414693 0.398552555560493 no 1293 0.40150383403798 1877 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2137 5261020 140 µM 0.248133529758738 0.399074227073626 no 1294 0.402015546837349 1867 763655 SGTC_2869 9037858 32.47 µM 0.247272431245994 0.399413865244298 no 1295 0.402348696547527 1942 27187042 SGTC_3026 9090633 49.47 µM 0.245977535537462 0.39992474683344 no 1296 0.402849811187345 1842 25236842 SGTC_789 1309-1135 70.6 µM 0.245810530427662 0.39999064867539 no 1297 0.402914452513986 1788 3092424 SGTC_545 4218-0007 221 µM 0.245142597982625 0.400254249779171 no 1298 0.403173010274981 1880 2840508 SGTC_1122 capsaicin 818.572 nM 0.244931228741841 0.400337676617174 no 1299 0.403254840484177 1928 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_3074 9116018 49.47 µM 0.244678933152198 0.400437262921966 no 1300 0.403352520605843 1882 17027303 SGTC_2678 equilin 100 µM 0.243345083569706 0.400963868457607 no 1301 0.403869041081224 1993 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2213 7173844 200 µM 0.242943836565697 0.401122316553754 no 1302 0.40402445298782 1875 892728 SGTC_2855 9016525 58.44 µM 0.242676093606444 0.401228054397449 no 1303 0.404128164231811 1889 43811474 SGTC_1006 4099-6547 255 µM 0.24194329819907 0.401517489107609 no 1304 0.404412049734544 1946 3146833 SGTC_364 0083-0097 67.7 µM 0.241265712476121 0.401785165549278 no 1305 0.404674591756633 1860 5207356 SGTC_1961 st076550 68.7 µM 0.239565970475014 0.402456841628634 no 1306 0.405333374114947 1895 1579337 SGTC_1347 1493-0251 600 nM 0.239164585002577 0.402615496654639 no 1307 0.405488981463191 1974 3986378 SGTC_1179 1021-1431 9.29 µM 0.238008262694166 0.403072643993554 no 1308 0.405937342815516 1909 2840958 SGTC_2589 lobaric acid 100 µM 0.237116413210469 0.403425323625977 no 1309 0.406283239759664 1823 73157 A novel microtubule depolymerizer. SGTC_1085 doxorubicin 7.67 µM 0.236688408222034 0.403594605034422 no 1310 0.406449264187676 1986 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_764 1951-2361 146 µM 0.236461135247825 0.403684501726035 no 1311 0.406537430899784 1805 5438930 SGTC_2453 5731132 22.18 µM 0.235963723747506 0.403881268113333 no 1312 0.406730409818426 1995 1362040 SGTC_72 0744-0168 198.391 µM 0.23557349983849 0.404035650188727 no 1313 0.406881819417597 1898 677577 SGTC_2656 pseudo-anisatin 100 µM 0.234807802668332 0.404338622045805 no 1314 0.407178955693459 1913 6708809 A neurotoxin. SGTC_1976 st070609 63.5 µM 0.233971002324137 0.404669793695021 no 1315 0.407503745345355 1937 682556 SGTC_299 1273-0059 1.44 µM 0.233198061956357 0.404975752843705 no 1316 0.407803805352408 1991 2848077 SGTC_295 k015-0027 31 µM 0.231407844561907 0.405684611672261 no 1317 0.408498985731597 1932 3887424 SGTC_2497 7-hydroxyflavone 100 µM 0.230819333467723 0.405917707642047 no 1318 0.408727580413146 1987 5281894 SGTC_447 ml7 120 µM 0.230276020421479 0.406132931300686 no 1319 0.408938646439516 2013 4216 Selective myosin light chain kinase inhibitor. SGTC_1274 0865-0114 173 µM 0.229891296846786 0.40628534976233 no 1320 0.409088119668218 1914 870624 SGTC_3240 9133527 49.47 µM 0.226602643574884 0.407588814404944 no 1321 0.410366368244352 1907 17617455 SGTC_2007 4011539 71.82 µM 0.226311784464306 0.407704146510955 no 1322 0.410479466733265 1870 45595301 SGTC_3291 9121177 71.43 µM 0.225334037009385 0.408091903709266 no 1323 0.410859711377475 1878 17015612 SGTC_711 k292-0785 179 µM 0.224718124354366 0.40833620992256 no 1324 0.411099281998742 1920 4146315 SGTC_703 3875-0075 71.8 µM 0.222573381920776 0.409187215027616 no 1325 0.411933777473044 1931 2850814 SGTC_2486 5283202 22.39 µM 0.222486611361341 0.409221653463541 no 1326 0.411967547345377 1824 1377751 SGTC_1113 artemisinin 1.17947 µM 0.221028119415955 0.409800620147808 no 1327 0.412535269131028 2037 2240 An anti-malaria and mitochondrial poison. SGTC_3242 9133940 49.47 µM 0.220771945476007 0.4099023319556 no 1328 0.412635004435238 1975 17248444 SGTC_3179 9107801 49.47 µM 0.219972674740643 0.410219714926722 no 1329 0.412946217942472 1904 4818259 SGTC_1793 st048256 72.231 µM 0.218999655439298 0.410606171204139 no 1330 0.413325158085955 1979 672022 SGTC_677 0929-0063 136 µM 0.218652194737023 0.410744194010321 no 1331 0.413460495448216 1952 1539583 SGTC_2662 daunorubicin 22.37 µM 0.217886727777093 0.411048301608673 no 1332 0.413758684210789 1968 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1443 4112-3303 14 µM 0.217499870548527 0.411202014056464 no 1333 0.413909403935018 1904 704433 SGTC_2584 androsterone 48.74 µM 0.21640722220069 0.411636236546462 no 1334 0.41433516857445 2012 2754130 A steroid. SGTC_2266 7929956 200 µM 0.21522988499481 0.41210423584402 no 1335 0.414794046010247 1956 2967153 SGTC_1897 st060201 15 µM 0.215188137710617 0.412120832963789 no 1336 0.414810319516584 1853 611878 SGTC_1074 carmofur 3.8 µM 0.214545445612061 0.412376362522633 no 1337 0.415060865717787 1988 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2789 5281112 71.43 µM 0.213786067170698 0.412678333564855 no 1338 0.415356945282118 1843 765948 SGTC_860 0443-0016 25.1 µM 0.213685856571032 0.412718186729024 no 1339 0.415396020713022 2069 5337942 SGTC_2802 7925815 54.55 µM 0.213654646123991 0.412730599123412 no 1340 0.415408190870641 1893 1262923 SGTC_952 1185-0122 232 µM 0.210726640748411 0.413895453271517 no 1341 0.416550292526717 1962 678600 SGTC_3047 9092122 49.47 µM 0.2090164536689 0.414576171708348 no 1342 0.417217697063419 1910 17173831 SGTC_869 0564-0080 44.1 µM 0.20895753285928 0.414599628979558 no 1343 0.417240695310922 1871 6843321 SGTC_384 k007-0144 5.16 µM 0.207312554753179 0.415254642452289 no 1344 0.417882884928428 1949 6824886 SGTC_511 blebbistatin 171 µM 0.20637493759729 0.415628097559953 no 1345 0.418249023173326 2028 3476986 A myosin inhibitor. SGTC_3086 9117350 49.47 µM 0.206177847265338 0.415706608806416 no 1346 0.418325995706922 2004 2679265 SGTC_988 1497-1057 103 µM 0.205543585239484 0.415959290913734 no 1347 0.4185737244309 2084 3533044 SGTC_1756 st041558 35.5 µM 0.205504350051262 0.415974922867256 no 1348 0.418589049889694 2090 3955792 SGTC_250 brefeldin a 552.239 µM 0.205302705748765 0.416055263418001 no 1349 0.418667815101673 1953 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_464 bw-b 70c 158 µM 0.20454921118317 0.416355507077905 no 1350 0.418962169926184 2030 5353454 SGTC_570 0987-0065 62.6 µM 0.203408801105424 0.416810017076984 no 1351 0.419407760659049 2067 3104428 SGTC_2030 5175110 200 µM 0.202677985194095 0.417101341993256 no 1352 0.419693365657661 2003 2831986 SGTC_367 0335-0881 7.1 µM 0.202505232433254 0.417170213029826 no 1353 0.419760884130346 2015 23828853 SGTC_3023 9089636 49.47 µM 0.202318255254015 0.417244757754117 no 1354 0.419833964718651 2103 17249241 SGTC_720 r052-1644 49.9 µM 0.202070501990669 0.417343537484889 no 1355 0.419930804078924 1951 1422863 YOR257W CDC31 SGTC_615 k087-0205 167 µM 0.201624929571172 0.417521201240257 no 1356 0.420104977242999 1909 9642773 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.200006200125173 0.418166781092271 no 1357 0.420737866048749 1838 641818 YHR062C RPP1 SGTC_2117 5521686 200 µM 0.199903665492589 0.418207681284108 no 1358 0.420777961829043 1893 803312 SGTC_645 0845-0943 5.41 µM 0.199318009497895 0.418441311414319 no 1359 0.421006996132085 1957 1885106 SGTC_3028 9087778 49.47 µM 0.198522357305598 0.418758759401118 no 1360 0.421318197120296 1934 17217395 SGTC_108 0509-0257 621.132 µM 0.198093824784439 0.418929756528409 no 1361 0.421485828104426 2036 536624 SGTC_1467 k284-1082 293 µM 0.195830148726731 0.419833283516017 no 1362 0.422371555828752 2090 3334705 SGTC_2814 7977482 42.97 µM 0.195764755042759 0.419859391152347 no 1363 0.422397148827406 2040 6456762 SGTC_38 0929-0051 58.268 µM 0.19490728517083 0.420201758205493 no 1364 0.422732765415184 2081 1379719 SGTC_3025 9087895 49.47 µM 0.194397421775252 0.420405363017187 no 1365 0.422932354270065 2076 17173641 SGTC_839 0122-0028 230 µM 0.193439788481627 0.420787834242995 no 1366 0.423307278569992 1984 759448 SGTC_1981 st071826 47 µM 0.193167950208204 0.420896417959828 no 1367 0.423413719009721 1957 11838600 SGTC_1156 4092-0367 4.88 µM 0.192462294442794 0.421178314819575 no 1368 0.423690050209447 1956 1357585 SGTC_572 0960-0087 17.7 µM 0.19193495424832 0.421389004189638 no 1369 0.423896578451951 1929 6796365 SGTC_2150 5556613 200 µM 0.19165704081269 0.421500048607721 no 1370 0.42400542926901 1980 743190 SGTC_762 1165-0429 115 µM 0.191354125778612 0.42162108989455 no 1371 0.424124079107244 2080 5967793 SGTC_338 4055-0136 114 µM 0.191178333334479 0.421691337885631 no 1372 0.424192939012685 1922 2900563 SGTC_1761 st044296 37 µM 0.190938150969874 0.421787320604319 no 1373 0.424287024925018 1969 1826700 SGTC_1718 roemerine 11.9335 µM 0.190802558388426 0.421841508752425 no 1374 0.424340142103341 2057 235224 An aporphine alkaloid with mutagenic activity. SGTC_1187 1391-0724 117 µM 0.188379642279694 0.422810050215705 no 1375 0.42528952855505 1963 6997986 SGTC_3101 9120531 49.47 µM 0.187600999618966 0.423121405824105 no 1376 0.425594721287681 2076 24824904 SGTC_1192 1488-0095 21.4 µM 0.187414999242467 0.423195788852186 no 1377 0.425667631632879 1978 915875 SGTC_2815 7968870 71.43 µM 0.186389537044485 0.423605928415334 no 1378 0.426069648445582 1963 2977326 YHR190W ERG9 SGTC_1715 st032160 10.2275 µM 0.186016372466066 0.423755198322119 no 1379 0.426215961018314 2052 5289825 SGTC_118 0083-0097 135.343 µM 0.185650887233833 0.423901407012507 no 1380 0.426359272472982 1949 5207356 SGTC_1218 1348-1416 30.7 µM 0.185142554471846 0.424104777833607 no 1381 0.426558612443324 1963 6787668 SGTC_2721 ifenprodil 61.44 µM 0.184856650061476 0.424219169695095 no 1382 0.426670736573482 2058 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2694 st077685 81.9 µM 0.184601555302635 0.424321239842405 no 1383 0.426770782977939 1948 2838096 SGTC_951 1171-0579 82.7 µM 0.183896798343153 0.424603258069435 no 1384 0.427047208264273 2016 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2624 nerol 100 µM 0.183652894012065 0.424700868753375 no 1385 0.427142882680537 2032 637566 A natural product oil. SGTC_1161 k007-0610 110 µM 0.183362603106952 0.424817049394625 no 1386 0.427256758375428 2099 5843850 SGTC_424 splitomicin 100 mM 0.182738985525779 0.425066656588109 no 1387 0.42750141237954 1879 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1415 3966-0071 78.1 µM 0.18079793154677 0.425843768541003 no 1388 0.42826309337082 2050 2893185 SGTC_1610 st001799 48.1 µM 0.178078285202328 0.426933078344306 no 1389 0.429330747674654 1916 621897 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.178019239048045 0.426956734527073 no 1390 0.429353933246914 1900 23665772 A membrane-active detergent. SGTC_2428 5615643 7.78 µM 0.176552460883374 0.427544466935637 no 1391 0.429929969036455 2044 2253075 SGTC_772 k072-0172 35.3 µM 0.176137166935013 0.42771090290554 no 1392 0.430093091184054 1870 5861980 SGTC_1905 st060207 84.5 µM 0.17587526707495 0.427815870254824 no 1393 0.430195968234169 1961 1948547 SGTC_1846 st056244 14.8 µM 0.173512125782213 0.428763228348715 no 1394 0.431124448722714 2025 5393182 SGTC_3063 1327-0034 4 µM 0.172929951895309 0.428996678883435 no 1395 0.431353244056912 2071 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1744 st037937 38.9 µM 0.172803381708482 0.429047436558878 no 1396 0.43140298940805 2047 1016152 SGTC_1679 SEC14.276 6.7 µM 0.172302045590251 0.429248495865761 no 1397 0.431600038128078 2113 1005053 YMR079W SEC14 SGTC_2696 st077691 74.316 µM 0.1721142953893 0.429323797233245 no 1398 0.431673837188443 2019 757133 SGTC_1331 1472-0049 76.2 µM 0.171834799868748 0.42943589985208 no 1399 0.431783703041832 1958 24051409 SGTC_97 0535-0701 19.132 µM 0.17130559926205 0.429648172050794 no 1400 0.431991738984792 2030 2832013 YGL099W LSG1 SGTC_1943 st076331 65.2 µM 0.171189800202361 0.42969462392039 no 1401 0.43203726368425 2133 24208415 SGTC_2766 oltipraz 83.91 µM 0.170923840696005 0.429801315139928 no 1402 0.43214182517342 2080 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1052 3253-3998 198 µM 0.170362267065993 0.430026610534941 no 1403 0.432362622415694 2094 5450317 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.170308982559862 0.430047988709594 no 1404 0.432383573700072 1954 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_2686 alizarin 95.37 µM 0.169271492288189 0.430464278988939 no 1405 0.43279154912364 1957 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_654 1124-0271 80.9 µM 0.167794517367642 0.431057044573763 no 1406 0.433372467927107 1942 5403748 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.166988307266955 0.431380672630279 no 1407 0.433689624596619 2077 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2432 5630864 12.22 µM 0.165990489723278 0.431781279328853 no 1408 0.43408221722458 1998 5714970 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.165729581755715 0.431886041009777 no 1409 0.434184882548832 2040 676296 Flavone; oxidizing agent. SGTC_1880 MG-132 525 µM 0.165034765047247 0.432165052256172 no 1410 0.434458309336033 2107 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_934 2950-0684 338 µM 0.164751071915883 0.43227898207066 no 1411 0.434569958306466 2130 1121253 SGTC_15 0266-0086 27.098 µM 0.164096067331858 0.432542050297019 no 1412 0.434827758831836 2123 1712902 YIL048W NEO1 SGTC_234 nsc-17383 10.7 µM 0.163004037118388 0.432980706718762 no 1413 0.435257628013012 2103 408974 SGTC_391 gliotoxin 8.33 µM 0.161247665022422 0.433686394929142 no 1414 0.435949170504394 2047 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2356 9061756 188.97 µM 0.160678943894041 0.433914945349417 no 1415 0.436173137134198 2123 20104043 SGTC_689 0833-0039 98 µM 0.160646352808365 0.433928043310885 no 1416 0.436185972367984 2106 5374726 SGTC_499 genistein 192 µM 0.160589990152589 0.433950694948847 no 1417 0.436208169635041 2141 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3201 9113999 49.47 µM 0.160352873224802 0.434045992457089 no 1418 0.436301555436027 2061 16649224 SGTC_1302 1159-0335 255 µM 0.1592858538026 0.434474875889493 no 1419 0.436721832747939 2005 649284 SGTC_467 ro 31-8220 72.8 µM 0.158258559152804 0.434887865018536 no 1420 0.437126530780073 2124 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1938 st074717 56.4 µM 0.158166389504538 0.434924922193593 no 1421 0.437162843814603 2091 17250979 SGTC_140 0062-0056 502.533 µM 0.155005887320146 0.436195958432061 no 1422 0.438408337997875 2075 3758964 SGTC_3194 9111903 49.47 µM 0.153290152917305 0.436886239791375 no 1423 0.439084732867499 2071 17087251 SGTC_528 3492-0019 172 µM 0.152849670138814 0.437063487734719 no 1424 0.439258413403071 2146 2869262 SGTC_1547 harmine 94.2 µM 0.15156871766229 0.437579007910378 no 1425 0.439763553991335 2110 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_906 1165-0455 526 µM 0.150636128824195 0.43795439562517 no 1426 0.440131379945607 2104 3252859 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.150476261202751 0.438018751508719 no 1427 0.440194439146926 2123 6710655 SGTC_2544 sphondin 68.51 µM 0.148871932878153 0.438664676136915 no 1428 0.440827344350105 2119 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2722 naftopidil 47.16 µM 0.148368755948874 0.438867295823929 no 1429 0.441025878139523 2114 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_3013 9080133 71.4286 µM 0.148347157770823 0.438875993354465 no 1430 0.441034400261658 2094 17050193 SGTC_1714 st033236 13.627 µM 0.147734694683699 0.439122642927765 no 1431 0.441276074831458 2104 2916566 SGTC_2225 6654152 15.4 µM 0.14754820722917 0.439197749379165 no 1432 0.441349666103715 2119 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2272 7805186 180 µM 0.146978470706864 0.439427220123265 no 1433 0.441574506819229 2169 2956062 YPR165W RHO1 SGTC_273 hydroxyurea 18.1 mM 0.146266624706263 0.439713956389623 no 1434 0.441855456043684 2044 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_734 2023-0417 80 µM 0.145857245480171 0.439878871377522 no 1435 0.442017041855673 2096 3935732 SGTC_2866 9034245 58.44 µM 0.145612481516237 0.439977477472735 no 1436 0.442113657093744 2174 6462273 SGTC_2046 4110841 106 µM 0.145283776750444 0.440109905982001 no 1437 0.442243411549524 2180 44119630 YMR134W ERG29 SGTC_3071 9117417 49.47 µM 0.144291332579108 0.440509782282959 no 1438 0.442635211143443 2160 45595590 YGL055W OLE1 SGTC_1432 4049-0298 68.4 µM 0.1442572045828 0.440523534240603 no 1439 0.442648685279335 2185 741646 SGTC_2000 st075254 36.4 µM 0.143954470299364 0.440645524881978 no 1440 0.442768211251168 2123 17234175 SGTC_1674 st016616 23.6 µM 0.143409506844173 0.440865139048097 no 1441 0.442983387603534 1992 625830 SGTC_2499 avocadenofuran 51.48 µM 0.143194307893058 0.440951866826983 no 1442 0.443068362569992 2088 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2504 purpurogallin 52.29 µM 0.143067514831831 0.441002967289631 no 1443 0.443118430193187 1999 5281571 An antioxidant. SGTC_3 0833-0587 95.581 µM 0.142941289535781 0.441053839905824 no 1444 0.443168274521296 2072 5382644 SGTC_2293 7624732 200 µM 0.142109787100981 0.441388984833601 no 1445 0.443496643824979 2108 894453 SGTC_1660 st012960 28.1 µM 0.14194448996156 0.441455614419311 no 1446 0.443561926083724 2061 24207266 SGTC_90 0870-0863 4.608 µM 0.141593966706289 0.441596912236983 no 1447 0.443700366393703 2045 1738164 SGTC_1774 st048371 48.465 µM 0.14115806539497 0.441772636777279 no 1448 0.443872536630752 2063 4242727 SGTC_1411 3909-8223 150 µM 0.140415940435403 0.442071835354374 no 1449 0.444165681989904 2169 X1411 SGTC_489 paxilline 115 µM 0.139736046199731 0.442345973715096 no 1450 0.444434272527875 2038 105008 A toxic potassium channel blocker. SGTC_3200 9114385 49.47 µM 0.139713875889484 0.442354913412946 no 1451 0.444443031284455 2031 17018030 YLR208W SEC13 SGTC_61 0978-8327 98.565 µM 0.138475811693068 0.442854182468985 no 1452 0.44493219245301 2183 6150059 YHR072W ERG7 SGTC_2892 9047358 58.44 µM 0.137836918507334 0.443111861847906 no 1453 0.445184653038998 2050 6466771 SGTC_1980 st071811 45.7 µM 0.137603000221629 0.443206212152735 no 1454 0.445277092126946 2130 4974850 SGTC_1400 3771-8998 51.5 µM 0.136167340299769 0.443785352014926 no 1455 0.445844496656844 2126 670767 SGTC_335 4077-0256 27.6 µM 0.135300635889679 0.444135035549808 no 1456 0.44618709116738 2147 3121989 SGTC_352 k048-0007 5.11 µM 0.134484089694627 0.444464521875772 no 1457 0.446509895691803 2160 6811911 SGTC_2146 5545642 200 µM 0.134346955464271 0.444519860976821 no 1458 0.446564112334896 2152 825326 SGTC_1946 st076057 65.1 µM 0.131001369763477 0.445870269965882 no 1459 0.447887111914759 2111 953009 SGTC_2372 9071633 200 µM 0.13095162359022 0.445890354241681 no 1460 0.447906788268293 2205 21321366 SGTC_2399 5884133 200 µM 0.130849268177326 0.44593167915033 no 1461 0.447947273821512 2038 722445 SGTC_1860 st056228 74.6 µM 0.128860892151625 0.446734580801756 no 1462 0.448733861071604 2051 688679 SGTC_3305 9127027 53.8275 µM 0.128767886765287 0.446772141534245 no 1463 0.448770658291722 2090 41905295 SGTC_908 3448-7491 47.7 µM 0.128536394054473 0.446865633200645 no 1464 0.448862249397114 2089 1203031 SGTC_2790 5423970 71.43 µM 0.126549909112073 0.4476680246304 no 1465 0.44964832240428 2162 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_145 3737-0113 38.366 µM 0.124690896277634 0.448419120954528 no 1466 0.450384132434229 2198 6849351 SGTC_743 1275-0778 158 µM 0.123947128590728 0.448719677107609 no 1467 0.450678568702454 2170 2849257 YMR203W TOM40 SGTC_1273 0849-0096 14.1 µM 0.123922680628803 0.448729557017458 no 1468 0.450688247410171 2073 5286025 SGTC_1983 st071813 46.9 µM 0.123542255116014 0.448883298660447 no 1469 0.45083885790441 2067 11838595 SGTC_1773 st048542 73.5835 µM 0.123385913237149 0.448946483445981 no 1470 0.450900755721643 2013 3237138 SGTC_639 0833-0042 114 µM 0.12332400888461 0.448971502137242 no 1471 0.450925264803485 2060 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_957 1187-1561 14.1 µM 0.122418827348409 0.449337355068749 no 1472 0.451283664292926 2191 1538454 SGTC_18 0111-0177 500 nM 0.119721288222891 0.45042789072843 no 1473 0.452351968043771 2152 721752 SGTC_374 0880-0231 82.3 µM 0.118581416516351 0.450888820305892 no 1474 0.452803494464119 2177 6833587 SGTC_2684 capsaicin 100 µM 0.117897642210631 0.45116534973888 no 1475 0.453074380731495 2136 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_522 1273-0010 11.6 µM 0.117871524731976 0.451175912542165 no 1476 0.453084727951134 2117 5705015 SGTC_649 1123-0311 367 µM 0.117621338785704 0.45127709806222 no 1477 0.453183848203125 2198 693629 YIL048W NEO1 SGTC_3236 9132701 49.47 µM 0.117279375723744 0.451415407154581 no 1478 0.453319334010749 2086 24282524 SGTC_2135 5326629 150.42 µM 0.116956423553783 0.451546032588812 no 1479 0.453447292689934 2085 5020077 SGTC_3187 9109394 49.47 µM 0.115514597693005 0.45212927602671 no 1480 0.454018625321759 2077 17098090 SGTC_2130 NSC 7 2.4545 µM 0.115487127324506 0.452140389271772 no 1481 0.454029511556864 2190 21448 SGTC_836 0330-0104 1.35 µM 0.115013632691708 0.452331949264432 no 1482 0.454217158213786 2206 46494820 SGTC_78 0336-0123 156.75 µM 0.11461205283598 0.452494423657016 no 1483 0.454376312943648 1994 6765896 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.113500772968976 0.452944075543981 no 1484 0.454816775150978 2159 65057 A dermal irritant. YDR527W RBA50 SGTC_62 0180-0423 3.232 µM 0.112678949788719 0.453276644796183 no 1485 0.455142545291868 2157 30102 YGL099W LSG1 SGTC_455 paf C-16 10 µM 0.112540348785908 0.453332736048336 no 1486 0.455197489612564 2164 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2334 9017922 200 µM 0.11157789682825 0.453722261991205 no 1487 0.455579049171366 2176 3163164 SGTC_554 4483-2211 187 µM 0.111568325344989 0.453726136009851 no 1488 0.455582843947318 2103 747107 SGTC_2095 5432005 200 µM 0.108482284252532 0.454975426028966 no 1489 0.456806566346791 2162 783734 SGTC_722 3534-0461 190 µM 0.108376372285116 0.455018309249117 no 1490 0.456848571456042 2105 658262 SGTC_526 4469-0568 170 µM 0.107627578482032 0.455321506999482 no 1491 0.457145559796315 2134 2901964 SGTC_25 0118-0223 35.662 µM 0.105301878311342 0.456263382766486 no 1492 0.458068136293407 2202 5333628 SGTC_531 3788-1495 174 µM 0.104862814382132 0.456441225209179 no 1493 0.45824233303098 2078 2896655 SGTC_2319 6033012 152.6 µM 0.10404476388369 0.456772599062343 no 1494 0.458566912437658 2146 847246 SGTC_2728 chlorpromazine 9.18 µM 0.103711832584637 0.456907470661702 no 1495 0.458699018125983 2237 2726 A thorazine and dopamine antagonist. SGTC_152 4469-0003 551.229 µM 0.102308704808362 0.457475936849818 no 1496 0.459255823063958 2247 697280 SGTC_2882 9058044 58.44 µM 0.102185759321064 0.457525751410462 no 1497 0.459304615499057 2070 18076804 SGTC_1014 4130-3005 69.3 µM 0.101959875896178 0.457617275691482 no 1498 0.459394261723231 2157 743608 SGTC_1504 k297-0033 30 µM 0.100980753347207 0.458014026110235 no 1499 0.459782869336113 2137 4388117 SGTC_903 1134-0042 114 µM 0.100590866602923 0.458172023855026 no 1500 0.459937623662502 2093 701009 SGTC_1041 0206-0046 107 µM 0.100547194568443 0.458189721926904 no 1501 0.459954958398607 2126 50494 SGTC_423 5-fluorouracil 457 µM 0.100528495315804 0.458197299815779 no 1502 0.459962380714288 2125 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_3017 9080681 49.47 µM 0.10037404293883 0.458259892360634 no 1503 0.460023688205808 2111 16451914 SGTC_1448 4255-0083 152 µM 0.0992618849389863 0.458710630034159 no 1504 0.460465170163694 2212 5399660 SGTC_1004 4084-0029 199 µM 0.0992054274485247 0.458733512662445 no 1505 0.460487582819287 2227 716894 YLR208W SEC13 SGTC_1822 st052468 42 µM 0.0990203354556017 0.458808532741419 no 1506 0.46056106204657 2187 2873678 SGTC_1112 tnp00069 1.16933 µM 0.0983822532633631 0.459067166592796 no 1507 0.46081438307723 2209 145826 SGTC_2195 6536160 144.242 µM 0.0982833803424325 0.459107244306422 no 1508 0.460853637424383 2185 3834386 SGTC_3260 9137109 49.47 µM 0.0967932221976194 0.459711323612052 no 1509 0.461445303281987 2235 17478346 SGTC_2798 7813637 45.45 µM 0.0956659939343781 0.460168340517999 no 1510 0.461892924947823 2188 956368 SGTC_1926 methyl fluorone black 53.6 µM 0.0945558657586614 0.460618475903015 no 1511 0.462333803362027 2227 72721 Reacts with homocysteine. SGTC_1760 st045453 10.4495 µM 0.0943736820366216 0.460692352695383 no 1512 0.462406160586916 2237 3323419 YIL048W NEO1 SGTC_1966 st070145 16.1 µM 0.0930157121789923 0.461243061686333 no 1513 0.462945539412385 2230 3748532 SGTC_2440 5628896 157.78 µM 0.0928645317416946 0.461304375783982 no 1514 0.46300559175778 2173 5522048 SGTC_1545 lovastatin 49.4 µM 0.0925086603779191 0.46144870980288 no 1515 0.463146955370826 2169 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_300 r073-0011 5.04 µM 0.0914954118060071 0.461859690084123 no 1516 0.463549475897357 2264 2735780 SGTC_3267 9137951 49.47 µM 0.091435189070394 0.461884118108168 no 1517 0.463573401005683 2101 16643986 SGTC_2078 5212016 200 µM 0.0903578057442407 0.462321159093212 no 1518 0.464001442810806 2269 1899708 SGTC_1806 st050005 60.3 µM 0.0902134442994488 0.462379722839945 no 1519 0.464058800442493 2120 5194765 SGTC_2126 5251174 33.877 µM 0.0900888394571492 0.462430272494047 no 1520 0.464108308989443 2258 790722 SGTC_1168 k815-0004 80.5 µM 0.0900003922238761 0.462466154108705 no 1521 0.464143451572584 2212 642433 SGTC_167 3672-0051 66.205 µM 0.0898811389461984 0.462514533721732 no 1522 0.464190834709811 2244 3237971 SGTC_2458 5808907 16.39 µM 0.0884476761659966 0.46309611543251 no 1523 0.464760434821839 2247 2731747 SGTC_2433 5607874 27.82 µM 0.0871608317832847 0.463618278648441 no 1524 0.465271836267822 2225 2252428 SGTC_1687 st020778 55.3625 µM 0.0865603169691009 0.463861971222588 no 1525 0.465510504964325 2161 4259299 SGTC_302 1094-0063 18.9 µM 0.0864283771804508 0.463915515013523 no 1526 0.465562944798776 2196 5440289 SGTC_132 0417-1715 25.805 µM 0.0841830535871239 0.464826811406011 no 1527 0.466455445817499 2269 6769098 SGTC_955 1216-0110 33 µM 0.0829345115374774 0.465333630022895 no 1528 0.466951806158302 2221 3619719 SGTC_441 propafenone 146 µM 0.0823533957914797 0.465569540608973 no 1529 0.467182847438538 2259 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2434 5670830 169.91 µM 0.0818517125116467 0.465773214412071 no 1530 0.467382316679858 2180 1549830 SGTC_769 0302-0231 76 µM 0.0806600770513523 0.466257031427396 no 1531 0.467856143609059 2240 571869 YER009W NTF2 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.0806276912122386 0.466270181131212 no 1532 0.467869021745341 2181 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2232 chlorophetanol 41.5365 µM 0.0800175336595522 0.466517931804912 no 1533 0.46811165542074 2269 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_363 0455-0021 3.06 µM 0.0797117306545211 0.46664210609711 no 1534 0.468233264715456 2227 4597466 SGTC_2378 9074213 121.43 µM 0.0790600527187454 0.466906737095141 no 1535 0.468492428663551 2253 657714 SGTC_2917 7979103 53.79 µM 0.0789805236710996 0.466939032964515 no 1536 0.468524057261119 2230 2980565 SGTC_2389 9091542 195.52 µM 0.0789439955190533 0.466953866717267 no 1537 0.4685385845257 2125 3626624 YOL127W RPL25 SGTC_2635 hydroquinidine 100 µM 0.0759661931748868 0.468163277894181 no 1538 0.469722997194736 2232 442912 An experimental heart treatment. SGTC_196 k015-0023 18.111 µM 0.0757156538525725 0.468265046043277 no 1539 0.469822660885415 2188 5211998 SGTC_1893 st059353 36.1 µM 0.0756620795890381 0.468286807980997 no 1540 0.469843972790894 2125 3112488 SGTC_2963 9082507 9 µM 0.0742086291074938 0.468877237461218 no 1541 0.470422189875229 2237 16459611 SGTC_2204 7233102 200 µM 0.0736580515422394 0.469100914370222 no 1542 0.470641239046444 2223 2172480 SGTC_635 k038-0028 24.7 µM 0.0702215933366549 0.470497222935678 no 1543 0.472008643875232 2212 4035102 SGTC_1597 7-benzyloxygramine 47.5 µM 0.0684540672860276 0.471215550035762 no 1544 0.472712091628007 2269 260807 SGTC_244 nsc-207895 1.295 µM 0.0679658614341205 0.471413974746947 no 1545 0.472906405024578 2266 42640 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0666617560362742 0.471944045530992 no 1546 0.473425490409413 2169 2374 Ca(2+)-ATPase inhibitor. SGTC_2294 7971431 200 µM 0.0663653204888328 0.472064542622607 no 1547 0.473543489775775 2256 5741572 SGTC_2203 7227154 166.4 µM 0.0663121835939374 0.472086142331391 no 1548 0.473564641735461 2294 896304 SGTC_1958 st076513 41.9 µM 0.0658145920305664 0.472288413166339 no 1549 0.473762719332382 2259 732122 YGL099W LSG1 SGTC_1876 myriocin 605 nM 0.0647372294135098 0.47272638519674 no 1550 0.474191610097034 2296 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2199 6590217 200 µM 0.0643837886722662 0.472870073982466 no 1551 0.474332319004291 2255 703109 SGTC_1240 0356-0016 42.1 µM 0.0639509874074864 0.473046031023574 no 1552 0.474504626626751 2240 4305613 SGTC_3183 9108214 49.47 µM 0.0637067554663173 0.473145326794826 no 1553 0.474601862796038 2280 4974831 SGTC_2698 st077697 67.5 µM 0.0631775925573688 0.473360470788742 no 1554 0.474812543838213 2213 3154499 SGTC_729 4092-0585 94.1 µM 0.0629160854617285 0.473466795703653 no 1555 0.474916662937516 2252 2169061 SGTC_247 mechlorethamine 29.705 µM 0.0620051214679075 0.47383719489459 no 1556 0.475279376754928 2267 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_483 fpl-64176 144 µM 0.0619028785497174 0.473878768421003 no 1557 0.4753200875727 2293 3423 SGTC_12 0849-0099 9.267 µM 0.0617011825036803 0.473960781936336 no 1558 0.475400399131934 2305 6071388 SGTC_1769 st044406 64.4 µM 0.0616063729985063 0.473999333697319 no 1559 0.475438150833227 2188 670903 SGTC_2918 7977171 22.06 µM 0.0614917724402264 0.474045933288119 no 1560 0.475483783324828 2316 2236483 SGTC_1111 tnp00062 510.699 nM 0.0608818717289261 0.474293940862205 no 1561 0.475726643462697 2290 676306 SGTC_924 2046-0044 21.3 µM 0.0598967011684446 0.474694567661143 no 1562 0.476118953632955 2309 3623589 SGTC_1153 4055-0057 267 µM 0.0598129590370885 0.474728623195807 no 1563 0.476152302119104 2245 882706 SGTC_1735 st034310 56.75 µM 0.0596707240874115 0.474786466513213 no 1564 0.476208944483208 2221 871153 SGTC_3114 9122766 49.47 µM 0.0592591261228022 0.474953855871733 no 1565 0.47637285825044 2178 17176985 SGTC_324 1315-0088 19.6 µM 0.0587115613045289 0.475176547308956 no 1566 0.476590925317641 2295 6787421 SGTC_2714 st079313 56.9 µM 0.0586441022022728 0.475203983072729 no 1567 0.476617791314893 2265 2939799 SGTC_470 aa-861 153 µM 0.0585942005182098 0.475224278271957 no 1568 0.476637665032096 2238 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1673 st016611 27.3 µM 0.0577986484840962 0.475547840869204 no 1569 0.476954507367285 2266 5226799 SGTC_1708 st033234 31.827 µM 0.0576889323893328 0.475592465272783 no 1570 0.476998204844304 2286 674664 SGTC_210 3551-0445 56.827 µM 0.057395873085823 0.475711661651203 no 1571 0.477114925192661 2272 2865180 YOR207C RET1 SGTC_776 4476-4378 112 µM 0.0570935213908906 0.475834639813642 no 1572 0.477235348594074 2171 2892008 SGTC_1739 st037196 92.5 µM 0.0563524564881878 0.476136069366838 no 1573 0.477530515478027 2298 612214 SGTC_2346 9031566 143.75 µM 0.0559657502137121 0.476293368310158 no 1574 0.477684545874452 2275 4771086 SGTC_853 0419-0306 21 µM 0.0547304463927692 0.476795872466566 no 1575 0.478176606496812 2215 762713 SGTC_14 0354-0009 295 µM 0.053863427451571 0.477148585618818 no 1576 0.478521987505357 2307 1713507 SGTC_1057 3448-5381 134 µM 0.053786524732591 0.477179871386718 no 1577 0.478552622842025 2301 5497911 SGTC_606 k015-0008 38.6 µM 0.0537539010791736 0.477193143470343 no 1578 0.478565618995655 2297 1970475 SGTC_3141 9094609 49.47 µM 0.0534764762320103 0.477306007563911 no 1579 0.478676136536037 2233 25236309 YDL196W YDL196W SGTC_2437 5741531 144.16 µM 0.0532707414864853 0.477389707319216 no 1580 0.47875809600056 2303 2262990 SGTC_501 nsc-95397 161 µM 0.0512952441286695 0.478193455754891 no 1581 0.479545128876535 2281 262093 SGTC_1380 2291-0730 164 µM 0.050480107751565 0.478525127179837 no 1582 0.479869900453305 2247 2999191 SGTC_2985 9022375 71.43 µM 0.0490529577486267 0.479105856943903 no 1583 0.48043854626081 2262 4939335 SGTC_3301 9125354 19.7965 µM 0.0486456361132524 0.479271610709149 no 1584 0.480600850316857 2305 41905162 SGTC_919 tnp00227 403.569 nM 0.0484334735989728 0.479357948658388 no 1585 0.480685391262305 2274 1269246 A methoxyflavone. YNL221C POP1 SGTC_2414 st077232 92.9 µM 0.047138889939375 0.479884790637965 no 1586 0.481201266042299 2216 729801 SGTC_2152 5568786 200 µM 0.0471077335096182 0.479897470452365 no 1587 0.48121368186645 2321 5399883 SGTC_3073 9114972 49.47 µM 0.0467521278869476 0.480042193648514 no 1588 0.481355391845449 2329 41905075 SGTC_2634 4'-methoxyflavone 100 µM 0.0464938371350816 0.480147313612045 no 1589 0.481458323015033 2266 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2884 9058502 51.95 µM 0.044705064902904 0.480875351124223 no 1590 0.482171198263821 2280 6471554 SGTC_2081 5214970 32.255 µM 0.0442006847558865 0.481080647513171 no 1591 0.48237221811613 2322 2063512 SGTC_2540 epiandrosterone 100 µM 0.041344675321076 0.482243213807985 no 1592 0.483510558871529 2343 441302 A steroid. SGTC_2700 st077718 96.8 µM 0.0397611919857634 0.482887851738367 no 1593 0.484141758028695 2296 904970 SGTC_1516 st013856 110 µM 0.0391035264280667 0.483155601406907 no 1594 0.484403924719121 2278 5281404 A mutagen and neurotoxin. SGTC_533 1222-0222 6.71 µM 0.038991565371642 0.483201183899776 no 1595 0.484448556679874 2319 3982874 SGTC_2426 5582046 32.21 µM 0.0386742875143573 0.483330357823711 no 1596 0.484575036829497 2330 2251934 SGTC_2333 9017922 200 µM 0.0382893484143206 0.483487081143121 no 1597 0.484728491647053 2335 3163164 SGTC_896 0964-0007 44.5 µM 0.0375232893336871 0.483798980440667 no 1598 0.485033885508764 2348 6756758 SGTC_925 2064-1272 59.6 µM 0.0372949192627454 0.483891962747904 no 1599 0.485124928258668 2266 6815817 SGTC_2812 7970281 58.44 µM 0.0371088102224359 0.483967738859424 no 1600 0.485199123663305 2337 2233435 SGTC_963 1269-2853 151 µM 0.0370951670456208 0.483973293834786 no 1601 0.485204562758474 2307 3668223 SGTC_214 4373-3496 70 µM 0.0368076074604861 0.484090377728324 no 1602 0.485319204142041 2283 3779166 SGTC_349 k015-0014 24 µM 0.0365162358430655 0.484209015143128 no 1603 0.485435366506177 2319 2196908 SGTC_2390 9097792 176.6 µM 0.036420638102816 0.48424793985981 no 1604 0.485473479134345 2302 4497149 SGTC_950 1165-0508 94.1 µM 0.03631640853528 0.484290379385338 no 1605 0.485515033225431 2293 6148369 SGTC_117 lucigenin 22.078 µM 0.0357293810644783 0.484529404768513 no 1606 0.485749071400963 2273 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2352 9027995 87.8 µM 0.035690652641593 0.48454517437366 no 1607 0.485764511958225 2294 2997347 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.034752234109872 0.484927290982406 no 1608 0.486138654630173 2309 368090 SGTC_303 1348-1668 34.2 µM 0.0345305389191621 0.48501756554607 no 1609 0.486227045163559 2317 5380509 SGTC_1481 3346-2004 36 µM 0.0345190946382648 0.485022225692692 no 1610 0.486231608050871 2349 2770522 SGTC_1209 2323-2347 50.3 µM 0.0343725195141086 0.485081911717823 no 1611 0.486290048384687 2356 5412760 SGTC_1736 st036774 51 µM 0.0340547072173041 0.485211327407229 no 1612 0.486416762960648 2349 1272247 SGTC_89 0302-0250 142.109 µM 0.0336259972260759 0.485385903983238 no 1613 0.486587695599428 2343 4203518 YLR208W SEC13 SGTC_3333 9141820 12.094 µM 0.031980008494923 0.486056198850788 no 1614 0.487243996826097 2317 1939433 SGTC_1332 1480-0653 17.5 µM 0.0314510099424814 0.486271631026791 no 1615 0.487454930599448 2357 5749438 SGTC_665 3914-0008 307 µM 0.0308514925417574 0.486515786512487 no 1616 0.487693987416289 2346 1069549 SGTC_900 1112-0045 141 µM 0.0306857915140814 0.486583269710953 no 1617 0.487760061278285 2351 56211 YIL048W NEO1 SGTC_2184 6075246 200 µM 0.0299391577140133 0.486887347619619 no 1618 0.488057788248136 2311 2267320 SGTC_421 streptovitacin 30 mM 0.0298448227363357 0.486925767512315 no 1619 0.488095405649325 2260 91467 include heat shock SGTC_2772 vinpocetine 57.06 µM 0.0295953690510374 0.487027363326782 no 1620 0.488194879329672 2335 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_3188 9110789 49.47 µM 0.0295387256340309 0.487050432793148 no 1621 0.488217466908314 2334 849217 SGTC_1281 0884-0031 11.8 µM 0.0293468032094221 0.487128598383697 no 1622 0.488293999698507 2350 1548255 SGTC_2202 7226349 200 µM 0.0282897868308039 0.487559105630263 no 1623 0.488715513134837 2357 844334 SGTC_1294 1000-1494 117 µM 0.027037706344072 0.488069078340518 no 1624 0.489214829851032 2341 712797 YDL207W GLE1 SGTC_172 1112-0046 2.638 µM 0.0257393759541092 0.488597909240347 no 1625 0.489732608390911 2331 2802135 YIL048W NEO1 SGTC_847 0342-0274 5.54 µM 0.0236493359451231 0.489449257946387 no 1626 0.490566159373438 2357 18097 SGTC_372 0155-0182 15.9 µM 0.022853610863994 0.489773398328155 no 1627 0.490883521943885 2317 771486 SGTC_1165 k072-0275 30.3 µM 0.0224565359002017 0.489935150237415 no 1628 0.491041891287456 2366 6153523 YGL055W OLE1 SGTC_833 3852-0053 558 µM 0.0210060783285247 0.490526020499104 no 1629 0.491620403470793 2342 3123681 SGTC_1124 fisetin 1.16336 µM 0.019680607641384 0.491065993294451 no 1630 0.492149080322433 2314 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1449 4112-4002 201 µM 0.0187618084347762 0.491440305148496 no 1631 0.492515560455077 2337 2059539 SGTC_110 0850-0284 111.64 µM 0.0184961101714428 0.491548550032908 no 1632 0.492621540334713 2370 3906265 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0182995885850592 0.491628612893099 no 1633 0.49269992783695 2364 688803 SGTC_2237 6667747 47.222 µM 0.0180635956972459 0.491724756800033 no 1634 0.49279405981765 2256 729940 YDL015C TSC13 SGTC_3092 9117248 49.47 µM 0.0174898524160998 0.491958502790158 no 1635 0.493022914104259 2379 17141857 SGTC_780 0109-0199 192 µM 0.0165438526213058 0.492343914007924 no 1636 0.493400258767166 2375 610414 SGTC_480 am 92016 50 µM 0.0162363642108594 0.492469189886328 no 1637 0.493522912418665 2334 2129 K+ channel blocker. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.0157462240966511 0.492668882628902 no 1638 0.4937184250316 2368 616764 SGTC_3202 9113761 49.47 µM 0.0154515971446769 0.492788920343201 no 1639 0.493835949879967 2357 4798415 SGTC_1936 st074407 74.3 µM 0.0154417761924548 0.492792921633579 no 1640 0.493839867405653 2372 809813 SGTC_2384 9036245 200 µM 0.0153327494204631 0.492837341791766 no 1641 0.493883357645825 2345 6462766 SGTC_2412 st077135 33.4 µM 0.0152805934581188 0.492858591430579 no 1642 0.493904162427014 2347 13258915 SGTC_2059 5238311 157 µM 0.0131179012590289 0.493739743254583 no 1643 0.494766864643813 2375 703021 SGTC_251 melphalan 456.522 µM 0.0109679341059942 0.494615740762627 no 1644 0.495624515081886 2351 460612 A DNA alkylator. SGTC_2893 9048488 25.97 µM 0.0103632577702385 0.494862119137467 no 1645 0.495865732314287 2378 6467338 SGTC_102 gallobenzophenone 83.616 µM 0.0098231983498717 0.495082170689061 no 1646 0.496081173874237 2390 70837 SGTC_2734 clemastine 41.6 µM 0.00937275387149991 0.495265709059632 no 1647 0.496260866943157 2392 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3104 9120930 49.47 µM 0.00912201003085591 0.495367877728254 no 1648 0.496360894985484 2378 17014836 SGTC_3166 9102297 49.47 µM 0.00818286343042216 0.49575054723247 no 1649 0.496735546233793 2388 25237072 SGTC_3264 9137442 49.47 µM 0.00810063988022699 0.495784050654396 no 1650 0.496768347597213 2385 17015726 SGTC_2863 9028737 58.44 µM 0.00806295962511097 0.495799404142547 no 1651 0.496783379353203 2395 6460917 SGTC_3083 9117465 49.47 µM 0.00796867363519124 0.495837822668375 no 1652 0.496820992812603 2369 16420915 SGTC_987 1497-1013 404 µM 0.00737346377647474 0.496080352528732 no 1653 0.497058440201018 2381 1676435 SGTC_146 3448-8650 53.125 µM 0.00721976117352462 0.496142981889646 no 1654 0.49711975703559 2381 2891488 YIL048W NEO1 SGTC_1359 1582-0056 520 nM 0.00706378198427156 0.496206538990747 no 1655 0.497181982142069 2383 3661189 SGTC_2711 st079103 59.1 µM 0.00690691752559349 0.496270456911168 no 1656 0.497244560480087 2384 54693780 SGTC_359 0081-0058 15.9 µM 0.00681627083587399 0.496307392969292 no 1657 0.497280722425893 2390 3494159 SGTC_1666 st014829 29 µM 0.00608459103886824 0.496605533697582 no 1658 0.497572614353532 2395 3858230 SGTC_2261 9010538 184.68 µM 0.00552454441654125 0.496833739604373 no 1659 0.497796036863335 2376 6457250 SGTC_325 2810-4341 181 µM 0.00539332228019587 0.496887209710027 no 1660 0.497848386141601 2394 774970 SGTC_3031 9088762 49.47 µM 0.00449895179537903 0.497251647255288 no 1661 0.49820518396602 2398 205253 SGTC_2576 guaiol 23.12 µM 0.00361839967039933 0.497610456345859 no 1662 0.498556470534065 2399 227829 SGTC_1826 st055655 41.6 µM 0.00359674668817699 0.497619279570661 no 1663 0.498565108767959 2389 676168 SGTC_1340 1486-1359 257 µM 0.00344748440153894 0.497680101464706 no 1664 0.498624655435565 2389 4309068 SGTC_2834 9001755 58.44 µM 0.00274576759181329 0.497966040068407 no 1665 0.498904598591885 2389 2989575 SGTC_938 3126-1755 342 µM 0.00200378690282865 0.498268386705455 no 1666 0.499200605218497 2400 1777771 SGTC_1668 st014914 51.6 µM 0.00157458789245998 0.498443279697289 no 1667 0.499371830575062 2399 2839556 SGTC_1334 1486-0610 236 µM 0.00152070702728317 0.49846523546805 no 1668 0.499393325904541 2392 3742339 SGTC_1967 st070177 51.4 µM 0.00138201111650458 0.498521752317884 no 1669 0.499448657509148 2402 5729214 SGTC_1367 1812-0510 76.9 µM 0.00137353892409245 0.498525204631356 no 1670 0.499452037421701 2403 1142582 YDR527W RBA50 SGTC_1191 1487-1166 10.6 µM 0.00103056908272365 0.498664960683581 no 1671 0.499588862492803 2403 3955771 SGTC_48 0382-0018 55 µM 0.00093072825193721 0.498705644643218 no 1672 0.499628693202346 2403 762596 SGTC_2460 5552655 174.22 µM 0.000880977873548635 0.498725917340016 no 1673 0.499648540723606 2402 5401989 SGTC_1929 genistein trimethyl ether 50.5 µM 0 0.499084906007123 no 1674 0.5 2406 136420 SGTC_1441 4106-0040 13 µM -0.000285587531716303 0.499201279917208 no 1675 0.499886067060392 2407 2904180 SGTC_2463 5473429 200 µM -0.00105875455954563 0.499516337647377 no 1676 0.499577618120542 2412 5399405 SGTC_1511 0906-3109 28.5 µM -0.0017594152607143 0.49980185004991 no 1677 0.499298095225847 2407 2882180 SGTC_1886 st057356 49.9 µM -0.001999704562108 0.499899765627553 no 1678 0.499202233833551 2410 24207747 SGTC_1212 0520-0165 585 µM -0.00249166399123147 0.499899765627553 no 1679 0.499005970913897 2410 5403258 SGTC_2775 cyproheptadine 69.59 µM -0.00466209430515117 0.499015337098664 no 1680 0.498140100203984 2413 2913 A selective serotonin reuptake inhibitor. SGTC_2034 5197015 53.07 µM -0.00468927455380975 0.499004261442248 no 1681 0.498129256972131 2423 780676 SGTC_2045 5106652 78.05 µM -0.00567101810137383 0.498604212180266 no 1682 0.497737603233062 2415 673349 SGTC_248 streptozotocin 5.23457 mM -0.00596681010200494 0.498483680581402 no 1683 0.497619601296011 2416 5300 DNA alkylating agent. SGTC_177 1327-0068 8.361 µM -0.00622180293025013 0.498379774253707 no 1684 0.49751787576499 2419 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1344 1488-0097 29.1 µM -0.00707447309775507 0.498032322865761 no 1685 0.497177717111445 2423 747966 SGTC_1472 k841-0093 193 µM -0.00739156710780319 0.497903111776338 no 1686 0.497051218213543 2443 X1472 SGTC_380 3970-0968 6 µM -0.00779517374691959 0.497738648398195 no 1687 0.4968902071036 2424 2891601 SGTC_1339 1486-1321 22.7 µM -0.00789031925529884 0.497699878150057 no 1688 0.496852250704873 2421 3469382 SGTC_886 0866-0150 153 µM -0.00802213858106183 0.49764616395342 no 1689 0.496799664066925 2418 271463 SGTC_1973 st070275 50.2 µM -0.00803527285892729 0.497640811954585 no 1690 0.496794424417039 2417 17118334 SGTC_1128 3448-9350 235 µM -0.0083840886703026 0.497498675496455 no 1691 0.49665527173196 2433 619386 SGTC_1170 0310-0127 64.8 µM -0.00863159782269423 0.497397819955161 no 1692 0.496556533440108 2431 774975 SGTC_2593 nobiletin 86.24 µM -0.00936852844512243 0.497097534950994 no 1693 0.496262552570384 2428 72344 An anti-infammatory. SGTC_1451 4152-0210 104 µM -0.0096914690120902 0.496965943411645 no 1694 0.496133723775028 2428 659563 SGTC_1386 3228-0095 33.8 µM -0.01021424471389 0.496752923932604 no 1695 0.49592517677631 2422 870181 SGTC_1570 verbenone 133 µM -0.01049633541211 0.496637978623654 no 1696 0.495812644903928 2427 29025 A natural terpanoid with antifungal properties. SGTC_2227 7312221 64.1025 µM -0.0106767680285028 0.496564456732115 no 1697 0.495740666738175 2428 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1912 st060209 90.8 µM -0.0107486199480868 0.496535178859257 no 1698 0.495712003614294 2426 688787 SGTC_2104 5389443 200 µM -0.0108342772696273 0.496500275652344 no 1699 0.495677833276834 2437 2244536 SGTC_1088 bifonazole 369 nM -0.0109688476166132 0.496445441670409 no 1700 0.495624150665798 2416 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1144 3486-0183 12.5 µM -0.011379477117924 0.49627812104807 no 1701 0.495460343424257 2436 6744069 SGTC_459 nigericin 15.3 µM -0.0115419242151038 0.49621192834695 no 1702 0.49539554066492 2441 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_911 3456-4043 236 µM -0.0125988748531064 0.495781252810661 no 1703 0.494973909102576 2438 914281 SGTC_91 0417-1751 58.384 µM -0.0132647974525971 0.495509911910393 no 1704 0.494708266640012 2438 6795624 SGTC_1098 clofazimine 15.1 µM -0.0133899925770403 0.495458899366521 no 1705 0.494658325447065 2474 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1304 1165-0502 251 µM -0.0148258608614409 0.494873839817395 no 1706 0.494085553931753 2444 767425 SGTC_2276 7947513 42.08 µM -0.0156555764865401 0.49453576845433 no 1707 0.493754583738713 2471 2105100 SGTC_1221 2958-7315 257 µM -0.0158738091341039 0.494446849222528 no 1708 0.49366753232673 2459 4562705 SGTC_478 N-arachidonylglycine 10 µM -0.0175914229102255 0.493747014801592 no 1709 0.492982399572841 2441 5283389 SGTC_2823 7987624 58.44 µM -0.0181828856527384 0.493506030170694 no 1710 0.492746477825643 2453 2239440 SGTC_735 3076-0345 636 µM -0.0184891080348058 0.493381264340223 no 1711 0.492624333305465 2453 2888990 SGTC_1139 k015-0024 46.9 µM -0.0185659268469821 0.493349965739935 no 1712 0.49259369229287 2430 2766652 SGTC_56 0957-0365 83.25 µM -0.0187180221904869 0.493287997038057 no 1713 0.492533025572215 2437 6752360 SGTC_770 0389-1121 67.2 µM -0.0190341155675035 0.493159210602331 no 1714 0.49240694502372 2476 6753108 SGTC_2270 7924575 90.91 µM -0.0205163397872079 0.492555315322912 no 1715 0.491815738777304 2452 1262135 SGTC_697 0508-1955 564 µM -0.0206606527583762 0.49249651949241 no 1716 0.491758178432355 2441 6243113 SGTC_1358 1509-0022 2.48 µM -0.0215018137383123 0.492153817904997 no 1717 0.491422678322217 2465 3258434 SGTC_1492 4158-0558 28.5 µM -0.0220700040314868 0.491922331927336 no 1718 0.491196056980557 2466 3967268 SGTC_1935 st074532 41.6 µM -0.0220978973945927 0.491910967982783 no 1719 0.49118493185187 2549 2829742 SGTC_2825 7998094 58.44 µM -0.0223430373129788 0.491811096607493 no 1720 0.49108715931459 2461 2987815 SGTC_2008 4012253 172 µM -0.0225702022870876 0.491718548783268 no 1721 0.490996556450369 2457 603940 SGTC_739 1486-1183 203 µM -0.0233808720671224 0.491388282679718 no 1722 0.49067323135745 2444 4346692 SGTC_892 0929-0076 29 µM -0.023382971273568 0.491387427472558 no 1723 0.490672394124139 2450 5751038 SGTC_197 4544-0043 41.561 µM -0.0240540266640693 0.491114044608756 no 1724 0.490404757053903 2450 896523 SGTC_2857 9024691 58.44 µM -0.0240722261101313 0.491106630350365 no 1725 0.490397498627132 2489 16478292 SGTC_2813 7971799 71.43 µM -0.0255703982781831 0.490496301914142 no 1726 0.489799998549353 2484 2234054 SGTC_3278 9139605 49.47 µM -0.0257886686277783 0.490407384316624 no 1727 0.489712949984832 2572 7958859 SGTC_253 dyclonine 31.25 µM -0.0257964089414287 0.490404231125224 no 1728 0.489709863073415 2450 3180 An oral anasthetic. SGTC_2876 9059903 25.97 µM -0.0262694198414077 0.490211540608787 no 1729 0.489521222960806 2446 6916095 SGTC_2582 agaric acid 100 µM -0.0263931723155276 0.490161127921305 no 1730 0.489471869978701 2443 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1253 0550-0034 176 µM -0.0266721336534005 0.490047488825581 no 1731 0.489360619672768 2485 5969915 SGTC_397 arbidol 50 µM -0.027731146222868 0.489616091564168 no 1732 0.488938291078597 2528 131410 A RNA synthesis inhibitor. SGTC_1422 4031-0024 15.5 µM -0.0277377099894681 0.489613417798571 no 1733 0.488935673521486 2448 782427 SGTC_2608 thymoquinone 42.66 µM -0.0285511554540835 0.489282062547323 no 1734 0.488611284243084 2444 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1874 staurosporine 7.6 µM -0.0310576595994319 0.488261091015018 no 1735 0.487611778055658 2480 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2297 7971671 152.32 µM -0.0318283893689779 0.487947165672166 no 1736 0.487304453329395 2491 909016 SGTC_3143 9086658 49.47 µM -0.0327818776103858 0.487558811473116 no 1737 0.486924265008577 2522 25236626 SGTC_213 1246-0773 967 nM -0.0338255850716614 0.487133724670879 no 1738 0.486508116839768 2502 6251622 SGTC_1220 1838-0075 193 µM -0.0362473883564966 0.48614741670043 no 1739 0.485542550175653 2490 5529645 SGTC_2880 9042983 58.44 µM -0.0365624438781849 0.486019112720824 no 1740 0.485416944469227 2509 6464714 SGTC_395 anisomycin 6.25 µM -0.0366564725630749 0.485980820529517 no 1741 0.485379457580633 2508 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_574 1315-0397 40 µM -0.0372120382450108 0.485754574908534 no 1742 0.485157970064851 2483 6794277 SGTC_2840 9008771 71.43 µM -0.0374176056803648 0.485670861875067 no 1743 0.485076017598565 2533 2992978 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.0374192629205701 0.485670187001257 no 1744 0.485075356918062 2534 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2689 tacrolimus 100 µM -0.0375454379391752 0.485618805182676 no 1745 0.485025055715606 2510 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_2100 5377183 190 µM -0.0378453798527716 0.485496661829481 no 1746 0.484905481189585 2520 2844202 SGTC_862 0452-0056 10.2 µM -0.038257839657013 0.485328700787505 no 1747 0.484741052619092 2486 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2568 diosmetin 100 µM -0.0382605128898393 0.485327612207532 no 1748 0.484739986933734 2471 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2706 st078239 82.5 µM -0.038820519036694 0.485099571839043 no 1749 0.484516742669288 2471 15434492 SGTC_746 1095-0025 46.6 µM -0.0394302114624574 0.484851304240594 no 1750 0.484273696684275 2480 6749286 SGTC_2549 cedrol 20.94 µM -0.0402211778780311 0.48452923038782 no 1751 0.483958396892398 2495 6708665 A sedative which affects the nervous system. SGTC_2282 7944268 200 µM -0.0414292358242855 0.484037340460165 no 1752 0.483476852990987 2509 2970414 SGTC_1007 4101-0031 70 µM -0.0418963742995413 0.483847140235784 no 1753 0.483290653375896 2473 1146276 SGTC_3250 9135583 49.47 µM -0.0423296462910064 0.483670732382384 no 1754 0.483117956068679 2575 7699353 SGTC_390 dec-rvkr-cmk 16.7 µM -0.0437344081748678 0.483098801972832 no 1755 0.482558055844488 2508 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1445 4239-0156 97.7 µM -0.0440420324653582 0.482973561371169 no 1756 0.482435449646446 2560 4008346 SGTC_2753 fluvastatin 17.09 µM -0.0452729737307998 0.48247243509497 no 1757 0.481944864590957 2544 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1855 st056195 39.6 µM -0.0458122340756093 0.482252906465575 no 1758 0.481729953833771 2512 4028379 SGTC_1157 4092-0394 27.6 µM -0.046363271066827 0.482028589215307 no 1759 0.481510355229179 2606 3659885 SGTC_3344 9148862 3.898 µM -0.0464601944519789 0.481989134034462 no 1760 0.481471730015608 2529 4905352 SGTC_2749 bexarotene 57.39 µM -0.0465032949813021 0.481971588901402 no 1761 0.481454553957069 2519 82146 An retinoic acid receptor inhibitor. SGTC_2332 7982454 138.89 µM -0.0465043882520322 0.481971143859052 no 1762 0.481454118276508 2468 2981748 SGTC_2551 apiole 73.87 µM -0.0465470787311604 0.481953765682331 no 1763 0.481437105662508 2482 10659 A possible DNA adduct former. SGTC_2621 lithochol-11-enic acid 100 µM -0.0465921149715591 0.481935432644761 no 1764 0.481419158274116 2481 6708711 SGTC_1471 k673-0312 37 µM -0.0473636142962168 0.481621382063434 no 1765 0.481111714021469 2500 24099884 SGTC_2120 5538279 151.968 µM -0.048172594270951 0.481292086663976 no 1766 0.480789345712893 2505 2058197 SGTC_201 4262-0159 12.803 µM -0.0484013396899274 0.481198978117836 no 1767 0.480698195819946 2496 1341029 SGTC_2958 9077254 16.72 µM -0.0486065594926503 0.481115446312307 no 1768 0.480616421213431 2557 16457351 SGTC_2108 5365811 200 µM -0.0523374262910993 0.47959699819273 no 1769 0.479129916150237 2551 780283 SGTC_1636 st007707 68.9 µM -0.052606879721031 0.479487342905165 no 1770 0.47902256766926 2527 403051 SGTC_3198 9112019 49.47 µM -0.0533773057797807 0.479173823142262 no 1771 0.478715643397288 2521 45595555 SGTC_1393 3470-5649 58.2 µM -0.0541265945496662 0.47886891741662 no 1772 0.478417151956847 2568 4108395 SGTC_1833 st055984 71 µM -0.0542416115393107 0.478822115004625 no 1773 0.478371334124806 2533 676288 SGTC_2571 chrysanthemic acid 100 µM -0.0546328152854545 0.478662929591108 no 1774 0.478215497486303 2553 2743 An insecticide. SGTC_1763 st044482 94.5 µM -0.0547381377559667 0.478620073217404 no 1775 0.478173542679635 2584 88505 SGTC_2626 ethyl orsellinate 100 µM -0.055595863201016 0.478271068602942 no 1776 0.477831880048533 2523 75653 A natural product. SGTC_1351 1496-0003 46.5 µM -0.0556222131167036 0.478260347203536 no 1777 0.47782138419414 2528 3891978 SGTC_313 3474-0040 5.03 µM -0.0562921058536292 0.477987782847645 no 1778 0.477554553740465 2499 1043375 YIL048W NEO1 SGTC_2681 menadione 3.18 µM -0.0571940994099683 0.477620798152397 no 1779 0.477195289228453 2538 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_721 1187-1332 279 µM -0.0572198964460246 0.477610302659478 no 1780 0.477185014526528 2490 25730 SGTC_1413 3910-0535 34.4 µM -0.0579159308409582 0.477327127793423 no 1781 0.476907796723024 2580 2876951 SGTC_1845 st056753 3.01 µM -0.0583744118122554 0.477140605486635 no 1782 0.476725198211539 2486 5375839 SGTC_2448 5185112 27.17 µM -0.0590637008182277 0.476860193742388 no 1783 0.47645068534747 2580 5718189 SGTC_856 0433-0016 11.3 µM -0.05934451551004 0.476745957945553 no 1784 0.476338852660015 2565 3911780 SGTC_2896 9052656 71.43 µM -0.0597487482320781 0.47658151888472 no 1785 0.476177872791629 2511 6469436 SGTC_1602 st001878 87.6 µM -0.0601607496180404 0.476413923689125 no 1786 0.476013803165529 2682 595405 YLR310C CDC25 SGTC_73 0327-0325 16.231 µM -0.0602533566707166 0.476376253279607 no 1787 0.47597692519665 2636 53298 SGTC_1379 2144-0755 36.5 µM -0.0605121650994089 0.47627097711066 no 1788 0.475873863628821 2519 5392327 SGTC_2669 eugenol 100 µM -0.061975698016751 0.475675683448186 no 1789 0.475291092481329 2494 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_3203 9113543 49.47 µM -0.0623656227240458 0.475517090238691 no 1790 0.475135835369717 2635 17018012 SGTC_2483 5729050 27.16 µM -0.0624302407627891 0.475490808661403 no 1791 0.475110106638208 2544 2865180 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.064326054831299 0.474719787329332 no 1792 0.474355303828676 2507 91467 include heat shock SGTC_2214 7179297 48.276 µM -0.0643766588417002 0.47469920812951 no 1793 0.474335157506525 2509 769744 SGTC_660 4031-1742 102 µM -0.0645552988261289 0.474626560910974 no 1794 0.474264038398121 2516 6738706 SGTC_1513 0337-0559 19 µM -0.0650283039019599 0.474434208822243 no 1795 0.474075732343677 2548 775073 SGTC_2957 9076800 11.52 µM -0.0663825936110423 0.473883506926261 no 1796 0.473536613959416 2567 16459615 SGTC_2973 9094665 17.96 µM -0.0664730584879201 0.473846722487458 no 1797 0.473500603234335 2673 25237061 YIL048W NEO1 SGTC_1811 st050069 61.5 µM -0.0677191806455419 0.473340052486096 no 1798 0.473004590206527 2527 3877702 SGTC_2864 9034755 47.6 µM -0.0681387342194815 0.473169472767068 no 1799 0.472837598272059 2528 4930451 SGTC_1345 1488-0192 31.4 µM -0.0686228252855147 0.472972659874925 no 1800 0.472644924870894 2536 658348 SGTC_2353 9059630 146.67 µM -0.0686713060080309 0.472952949832102 no 1801 0.472625629378732 2585 4779114 SGTC_846 0335-0850 148 µM -0.0724890917991178 0.471401024724568 no 1802 0.471106343057648 2543 6819598 SGTC_3008 9078912 71.4286 µM -0.072647426045643 0.471336671267234 no 1803 0.471043342935041 2567 16648731 SGTC_1258 0671-0043 57.1 µM -0.0726899140527799 0.471319402545781 no 1804 0.47102643736848 2583 4298767 SGTC_1800 st050079 29.0735 µM -0.0731126218385456 0.471147601171912 no 1805 0.470858248882898 2547 3645560 SGTC_2304 7443016 91.4 µM -0.0738391871119227 0.470852315384573 no 1806 0.470569172655493 2528 939854 SGTC_2909 7941780 10.49 µM -0.0741078238936165 0.470743141873961 no 1807 0.470462294907696 2538 1243215 SGTC_831 k061-1017 217 µM -0.0746561469742695 0.470520311181844 no 1808 0.470244149948791 2613 1240153 SGTC_2485 5633444 17.78 µM -0.0763842581840343 0.469818092106647 no 1809 0.469556696581826 2587 5724239 SGTC_188 3229-0966 278.469 µM -0.0776622481012378 0.469298840351313 no 1810 0.469048362509678 2565 5722370 SGTC_1494 4358-1428 177 µM -0.0791018881721416 0.468713972154983 no 1811 0.46847579083861 2544 1564571 SGTC_2253 7938677 135.83 µM -0.0800921701970913 0.46831169928076 no 1812 0.468081975010403 2699 2301972 SGTC_2281 7943571 200 µM -0.0807005127586554 0.468064594068158 no 1813 0.467840064512943 2582 1244024 SGTC_2177 5811945 192 µM -0.081454809600561 0.467758220172142 no 1814 0.467540131059038 2642 5343475 SGTC_680 0417-1641 114 µM -0.081538189052203 0.467724354982281 no 1815 0.467506977750304 2554 2835990 SGTC_460 trequinsin 123 µM -0.0815658641314378 0.467713114592833 no 1816 0.467495973644678 2544 5537 A vasodilator. SGTC_1207 2099-0101 141 µM -0.0824992708057356 0.467334021343201 no 1817 0.467124849086092 2612 5837381 SGTC_311 1315-0136 58 µM -0.0834717220613619 0.466939102066098 no 1818 0.466738230715944 2676 6759207 SGTC_779 1360-0071 233 µM -0.0847611768014621 0.466415495700921 no 1819 0.466225629423446 2703 7566 SGTC_1573 oleylamine 1.06 µM -0.085174174762951 0.466247802672025 no 1820 0.466061460755261 2550 5356789 An amine of the fatty acid oleic acid. SGTC_1032 k061-1018 98.7 µM -0.0852735712132574 0.466207444790469 no 1821 0.466021951051208 2759 4005393 SGTC_1373 2887-0003 58.5 µM -0.0855824626500377 0.466082028003972 no 1822 0.465899170040517 2641 776948 SGTC_1321 1326-2144 215 µM -0.0870754891019868 0.465475873800888 no 1823 0.465305754116172 2650 3513030 SGTC_2025 5147754 141 µM -0.0876728723552398 0.465233364371834 no 1824 0.465068340650746 2622 315777 YLR208W SEC13 SGTC_753 1322-0200 289 µM -0.0880019829528917 0.465099766499921 no 1825 0.464937550045276 2674 5403907 SGTC_1414 3917-0015 5.4 µM -0.0880213590938059 0.46509190114735 no 1826 0.464929849963885 2573 6618702 SGTC_2524 avocatin b 10.57 µM -0.0881106785628635 0.465055643891537 no 1827 0.464894354562938 2624 6710748 SGTC_1615 st002656 86.5 µM -0.0884184580330746 0.464930709871564 no 1828 0.464772045680714 2541 1584458 SGTC_3258 9138477 49.47 µM -0.0889487323077454 0.464715468748132 no 1829 0.464561327113769 2572 4970355 SGTC_1725 st036284 20.55 µM -0.0894600775490662 0.464507920796564 no 1830 0.464358139913249 2710 707914 SGTC_1913 st060213 96.1 µM -0.0894868196003039 0.464497066833557 no 1831 0.464347513996461 2619 688959 SGTC_2786 7743617 45.45 µM -0.0903734429208973 0.464137222507566 no 1832 0.4639952298989 2606 583674 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.0909340399329752 0.463909714111552 no 1833 0.463772501138015 2610 279621 SGTC_997 3996-0078 137 µM -0.0912751336996859 0.463771293000598 no 1834 0.463636987964881 2611 735687 SGTC_1937 st074714 47.2 µM -0.0914146422318375 0.463714679549423 no 1835 0.463581563822412 2561 17250970 SGTC_1427 4048-4900 550 nM -0.0926690904866787 0.463205649599562 no 1836 0.463083226766831 2660 24132586 SGTC_1107 amlodipine 47 µM -0.0933678711760011 0.462922124476564 no 1837 0.462805657039423 2594 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2528 xanthyletin 44.79 µM -0.0965782672978576 0.461619774117544 no 1838 0.461530657992293 2612 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1203 3992-3522 103 µM -0.097093317914143 0.461410873241053 no 1839 0.461326143661478 2746 5322312 SGTC_1499 4480-0877 67.3 µM -0.0974068308751647 0.461283719817095 no 1840 0.46120166013665 2572 2861909 SGTC_1782 st039423 80.636 µM -0.0978167122545037 0.461117487619024 no 1841 0.461038918282255 2618 2068169 SGTC_2021 4019055 173 µM -0.0984165909788814 0.460874212025845 no 1842 0.46080075046921 2684 44827708 YER133W GLC7 SGTC_2581 avocatin a 64 µM -0.0992594033608459 0.460532441561256 no 1843 0.460466155305023 2633 6710728 A skin care supplement. SGTC_327 1273-0057 3.96 µM -0.0996728811854867 0.460364782020127 no 1844 0.460302015491256 2632 3108138 SGTC_2960 9079389 5.97 µM -0.100781708896802 0.459915202581272 no 1845 0.459861873544551 2636 16457355 SGTC_399 oxolinic acid 75 µM -0.101344971333283 0.459686844754675 no 1846 0.459638308988601 2585 4628 A DNA gyrase inhibitor. SGTC_2844 9010103 25.97 µM -0.101461446305163 0.459639625134681 no 1847 0.45959208048462 2750 2480525 SGTC_381 3461-2219 42.7 µM -0.102427430768748 0.459248031508264 no 1848 0.459208705782714 2630 2883159 SGTC_2041 5107442 45.335 µM -0.102632160417822 0.459165042665003 no 1849 0.459127458643627 2622 793005 SGTC_1395 3486-0190 4.35 µM -0.103361819634559 0.458869283811329 no 1850 0.458837906657321 2607 6748079 SGTC_1306 1185-0270 9.02 µM -0.103602935475762 0.458771555313578 no 1851 0.45874222901486 2628 1548076 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.103881222021968 0.458658763972296 no 1852 0.458631804564636 2580 88881 An O-methylated flavonoid and antioxidant. SGTC_1907 st060210 83.7 µM -0.103964602176254 0.458624970102814 no 1853 0.458598719836062 2659 688793 SGTC_2720 fluspirilene 36.88 µM -0.105597347218239 0.457963281195863 no 1854 0.457950914798721 2664 3396 An atypical antipsychotic. SGTC_724 3910-0327 137 µM -0.106573218660686 0.457567853450283 no 1855 0.45756378298349 2634 2885483 SGTC_1019 4262-0212 3.4 µM -0.108992791968497 0.45658761283815 no 1856 0.456604103725765 2592 4677213 SGTC_206 4546-0025 72.014 µM -0.109355152195246 0.456440832601771 no 1857 0.456460401856392 2619 6620745 YIL048W NEO1 SGTC_1848 st056003 16.4 µM -0.110107765148024 0.456135992807518 no 1858 0.456161954953968 2572 146492 SGTC_93 0109-0045 59.227 µM -0.110699385514942 0.455896379874139 no 1859 0.455927366637102 2572 88733 SGTC_1242 0402-0103 60.1 µM -0.111417201357784 0.455605677892058 no 1860 0.455642760137469 2605 432868 SGTC_548 1436-0017 110 µM -0.111480228931755 0.455580154036976 no 1861 0.455617771446249 2651 9677137 SGTC_2316 5844804 197.44 µM -0.111607428430715 0.455528643465105 no 1862 0.455567340895093 2696 776813 SGTC_2757 clomiphene 4.22 µM -0.111651389543264 0.455510841194183 no 1863 0.455549911880171 2704 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1722 st034304 3.6505 µM -0.112147078183185 0.455310115807622 no 1864 0.455353394922742 2633 4036148 YLR033W RSC58 SGTC_2085 5307070 144.047 µM -0.112764726649951 0.455060019676117 no 1865 0.455108541989527 2597 2840351 SGTC_623 k072-0108 16.9 µM -0.114036560212811 0.454545089331481 no 1866 0.454604405806582 2688 5382803 SGTC_328 k915-0120 63.5 µM -0.114484917637272 0.454363579936247 no 1867 0.454426700883882 2740 6624543 SGTC_3022 9087993 49.47 µM -0.115870326486066 0.453802782599162 no 1868 0.453877656645434 2614 17173644 SGTC_1234 0326-0494 15.5 µM -0.115918165617316 0.453783419515604 no 1869 0.453858699334117 2717 1547813 SGTC_2796 7949634 45.45 µM -0.117003177640498 0.453344286061921 no 1870 0.45342876769314 2600 2971588 SGTC_723 4182-0001 115 µM -0.118493846166546 0.452741065673616 no 1871 0.452838185396896 2645 744821 YLR208W SEC13 SGTC_1474 0330-0125 5.35 µM -0.118713049048017 0.452652371249009 no 1872 0.452751349006647 2653 X1474 SGTC_1604 st002052 72.4 µM -0.119010835707522 0.452531883842714 no 1873 0.452633385571489 2743 6254834 YHR062C RPP1 SGTC_968 1309-0633 340 µM -0.119298973409617 0.45241530465993 no 1874 0.45251924839633 2629 3761976 SGTC_2031 5180455 200 µM -0.11935362162467 0.452393194707132 no 1875 0.452497601574702 2617 29949 SGTC_2402 5553605 200 µM -0.12038745012951 0.451974949110068 no 1876 0.452088116221361 2749 6758546 SGTC_2482 5981709 142.65 µM -0.121602566516179 0.451483429863137 no 1877 0.451606890395271 2687 877755 SGTC_183 3914-0051 30.55 µM -0.121637247960064 0.451469402173881 no 1878 0.451593156449641 2685 1596232 SGTC_1672 st016598 6.51 µM -0.122606917488503 0.451077222141422 no 1879 0.451209188206976 2687 4665860 YNL267W PIK1 SGTC_2702 st077768 96.8 µM -0.122896999526576 0.450959908563285 no 1880 0.451094330823557 2697 6484119 SGTC_401 neomycin 50 µM -0.123365677197868 0.450770377256696 no 1881 0.450908767524495 2660 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2284 7945075 39.21 µM -0.123433762128845 0.450742844925697 no 1882 0.450881811585822 2733 1245402 SGTC_2523 spermine 47.74 µM -0.124244502461692 0.45041501425531 no 1883 0.450560843660866 2677 1103 A DNA binding polyamine. SGTC_1385 3091-4834 14.1 µM -0.125754174135325 0.449804654271192 no 1884 0.449963258723963 2729 4072814 SGTC_1483 3453-0561 55.9 µM -0.126922482323334 0.449332388899166 no 1885 0.449500876112159 2722 4546991 SGTC_2273 7815444 169.05 µM -0.126977537481714 0.449310135710687 no 1886 0.449479088558439 2651 2824616 SGTC_2833 9001315 45.46 µM -0.127168250692547 0.44923305103307 no 1887 0.449403616802648 2690 2989378 SGTC_1712 st032288 53.4 µM -0.127847941906703 0.448958341157075 no 1888 0.449134654592031 2660 2883011 SGTC_686 1319-0111 510 µM -0.127977387086702 0.44890602624382 no 1889 0.449083434180655 2726 4562600 SGTC_2580 diallyl disulphide 81.36 µM -0.129095427530532 0.44845421034142 no 1890 0.448641070018212 2678 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1370 2001-0092 44.6 µM -0.130437018052161 0.44791214298655 no 1891 0.448110340291572 2724 790957 SGTC_44 0929-0055 61.211 µM -0.130664378651413 0.447820287935432 no 1892 0.448020406205746 2646 1379590 SGTC_2277 7947813 106.88 µM -0.130926040131759 0.447714578585196 no 1893 0.447916907471909 2884 1246798 SGTC_1984 st072354 53.1 µM -0.132642725572416 0.447021142492954 no 1894 0.447237970413629 2649 5762938 SGTC_1794 st048918 76.9 µM -0.133588369629625 0.446639229071955 no 1895 0.446864040720649 2600 672303 SGTC_3238 9133470 49.47 µM -0.133650875585251 0.446613986785526 no 1896 0.446839326070108 2754 3534688 SGTC_2114 5491910 81.25 µM -0.133935403261877 0.44649908640376 no 1897 0.4467268273672 2748 2849228 SGTC_3066 9117245 49.47 µM -0.134063673558265 0.446447288672087 no 1898 0.446676112289549 2699 17176980 SGTC_1056 3448-1962 115 µM -0.136003685558189 0.445663990683543 no 1899 0.4459091836926 2751 715507 SGTC_2172 5754775 163.918 µM -0.137154787764983 0.445199322438582 no 1900 0.445454223615844 2665 2263357 SGTC_3288 9119690 36.221 µM -0.13729187777203 0.445143987984164 no 1901 0.445400045121827 2684 17595618 YKL019W RAM2 SGTC_1526 st051518 75 µM -0.137504169267696 0.445058301615316 no 1902 0.445316148725015 2722 673993 SGTC_1776 st049249 45.9 µM -0.137567270241626 0.445032832915845 no 1903 0.44529121204946 2681 1822314 SGTC_3152 9099253 49.47 µM -0.137807561891765 0.444935848918348 no 1904 0.445196253929996 2742 25236131 SGTC_858 0438-0351 2.77 µM -0.138107903756083 0.444814632717837 no 1905 0.445077569672482 2666 2799119 SGTC_2151 5563267 85.4165 µM -0.140261026706045 0.443945796801252 no 1906 0.444226878024792 2697 5310824 SGTC_787 4152-0075 138 µM -0.141114468504605 0.443601487202558 no 1907 0.443889756907492 2694 9566539 SGTC_3285 9112818 20.8695 µM -0.141679709420934 0.443373471786706 no 1908 0.443666501391708 2638 17017947 YPR165W RHO1 SGTC_2652 actinonin 100 µM -0.143421341914057 0.442671023979779 no 1909 0.442978714400914 2636 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1285 0929-0069 65.5 µM -0.143584684550971 0.442605152654319 no 1910 0.442914217642214 2699 1206237 SGTC_2248 tofa 1.1 µM -0.147257880596328 0.441124282133076 no 1911 0.441464238195104 2658 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1239 0337-0584 35.4 µM -0.147604919238082 0.440984413689252 no 1912 0.441327286320163 2810 914301 YML130C ERO1 SGTC_1389 3405-0187 19 µM -0.147871091458289 0.440877142166659 no 1913 0.441222251517575 2733 799890 SGTC_2537 larixol 68.93 µM -0.149449119038244 0.440241261996257 no 1914 0.440599627750659 2650 6708759 SGTC_153 4077-0274 519.67 µM -0.150065541031922 0.439992911064633 no 1915 0.440356453174446 2727 3121976 SGTC_2707 st078556 66.6 µM -0.150617927929977 0.439770379357179 no 1916 0.440138559145502 2755 17250899 SGTC_2927 9011802 47.9 µM -0.152182485614121 0.439140193298913 no 1917 0.439521503758002 2778 43912568 SGTC_159 3970-0959 50 µM -0.152945907826966 0.438832751392025 no 1918 0.439220466281647 2771 6615653 SGTC_837 0091-0265 12.5 µM -0.154176059390268 0.438337428086717 no 1919 0.438735459157226 2683 759367 SGTC_225 nsc-122657 1.016 µM -0.154790779403774 0.438089945824887 no 1920 0.438493130282621 2785 275685 SGTC_2005 4024620 188 µM -0.155151576402967 0.437944702579034 no 1921 0.438350911172187 2678 236743 SGTC_1810 st050138 53 µM -0.155425914550785 0.437834269995234 no 1922 0.438242777774564 2674 3444541 SGTC_331 k048-0133 24.5 µM -0.155486304758665 0.437809961059524 no 1923 0.438218974928972 2687 6813582 SGTC_2362 9071156 126 µM -0.156804316697599 0.437279478902807 no 1924 0.437699535353696 2851 653133 SGTC_979 1426-2828 121 µM -0.157152814408778 0.437139232046934 no 1925 0.43756220738605 2804 747872 SGTC_2407 paclitaxel 400 µM -0.157325865234968 0.43706959367904 no 1926 0.437494018287625 2952 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_310 1273-0058 1.06 µM -0.158104040941999 0.436756467691769 no 1927 0.437187408226156 2768 2734232 SGTC_2616 abietic acid 100 µM -0.158172497132559 0.436728923862233 no 1928 0.437160437512516 2736 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1686 st019653 115.5 µM -0.159025767387656 0.436385630358168 no 1929 0.436824286358781 2692 97252 SGTC_1699 st031318 29.054 µM -0.159099381557729 0.436356015644931 no 1930 0.43679528772985 2791 5340658 SGTC_2552 juarezic acid 87.02 µM -0.160860395462575 0.435647672867986 no 1931 0.436101677923999 2660 1549512 SGTC_2484 5809818 12.04 µM -0.161877946374723 0.435238471439642 no 1932 0.43570098499427 2758 2870548 SGTC_1625 st003711 30.1 µM -0.16233655455234 0.435054067810442 no 1933 0.435520415036582 2861 24207034 YER133W GLC7 SGTC_2676 harmalol 100 µM -0.162578277994776 0.434956877929284 no 1934 0.435425245534786 2703 5459187 A monoamine oxidase inhibitor SGTC_425 3825-7017 13.1 µM -0.163284694807503 0.434672871066575 no 1935 0.435147141975009 2952 3397440 SGTC_3355 9151058 44.0485 µM -0.163475711072716 0.434596080928261 no 1936 0.435071947819957 2676 17015728 SGTC_845 0330-0138 4.51 µM -0.163566848500228 0.434559443788424 no 1937 0.435036072111502 2774 9039800 SGTC_2601 securinine 100 µM -0.163702519897018 0.434504905085826 no 1938 0.434982666860578 2724 442872 A GABA receptor antagonist. SGTC_2207 7258803 200 µM -0.164426278687002 0.434213981532828 no 1939 0.434697788849917 2773 3666799 SGTC_2154 5570129 200 µM -0.164553456336579 0.434162864622166 no 1940 0.434647734073582 2680 673366 SGTC_2283 7944793 200 µM -0.166120805828306 0.433532985579447 no 1941 0.434030940481243 2753 2970533 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.167686710983613 0.432903855515052 no 1942 0.433414875624467 2700 66535 A nucleotide analog. SGTC_1398 3558-0053 112 µM -0.168234065267801 0.432683986282082 no 1943 0.433199571322091 2698 4532369 SGTC_3322 9139058 2.11 µM -0.168810111768579 0.432452614050975 no 1944 0.4329730022179 2875 4908926 YPR165W RHO1 SGTC_1130 3454-2858 15.9 µM -0.16894528223418 0.432398325445408 no 1945 0.432919840512288 2821 715628 YIL048W NEO1 SGTC_1232 0279-0259 161 µM -0.169275903939083 0.432265543006924 no 1946 0.432789814164875 2710 1560000 SGTC_3234 9132280 49.47 µM -0.171531743881541 0.431359770127018 no 1947 0.431902836153674 2776 17612295 SGTC_790 1575-0012 79.1 µM -0.17329149987694 0.430653436915615 no 1948 0.431211152365716 2872 378741 YLR208W SEC13 SGTC_1486 3970-0793 4.53 µM -0.173703472551599 0.430488110729337 no 1949 0.431049254157308 2812 2844330 SGTC_1998 st075797 76.8 µM -0.174427227718461 0.430197694574679 no 1950 0.430764858837777 2666 24208315 SGTC_2053 5265679 138 µM -0.175194729007172 0.429889765972275 no 1951 0.430463312962172 2707 764595 SGTC_927 2425-1185 123 µM -0.175620475263697 0.429718971019644 no 1952 0.430296057714811 2690 730375 SGTC_1881 5652484 16 µM -0.176177900464631 0.429495370830782 no 1953 0.430077091046725 2821 2255129 SGTC_2251 lansoprazole 556 µM -0.176209873630503 0.429482546107422 no 1954 0.430064532062195 2717 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2451 5856223 45.7 µM -0.176765330512222 0.429259759263102 no 1955 0.429846361205331 2757 2179896 SGTC_1328 1441-0025 69.2 µM -0.182456205462016 0.426978530369616 no 1956 0.427612360194835 2708 4562601 SGTC_1742 st038235 28.8875 µM -0.183058485631541 0.42673724340955 no 1957 0.427376064476731 2861 564103 YBR002C RER2 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.183197438251513 0.426681579758365 no 1958 0.427321552166481 2703 2346 DNA damaging agent; causes G2/M arrest. SGTC_1043 0916-0009 19.3 µM -0.183675328220268 0.426490150832994 no 1959 0.427134082412676 2822 3101130 SGTC_3345 9148410 3.559 µM -0.184483575092546 0.42616642990015 no 1960 0.426817055596128 2841 4903596 SGTC_2445 5742597 35.57 µM -0.184772414102413 0.426050755476053 no 1961 0.42670377281406 2749 1774255 SGTC_801 0866-0028 10.1 µM -0.186667506897668 0.425291965811735 no 1962 0.425960666995506 2720 6849771 SGTC_309 k408-0051 1.48 µM -0.186906825963849 0.425196162766969 no 1963 0.425866843584584 2773 3640463 SGTC_2467 5474540 200 µM -0.187157901996572 0.425095657978549 no 1964 0.425768415446024 2724 5413519 SGTC_2388 9080168 200 µM -0.187600758151159 0.424918396200926 no 1965 0.425594815939073 2727 15943073 SGTC_3129 9127257 49.47 µM -0.187632753540279 0.424905590012542 no 1966 0.425582274312399 2766 837894 SGTC_198 3454-2873 16.191 µM -0.188355008506601 0.424616527808848 no 1967 0.425299183196061 2739 710957 SGTC_1183 1254-0324 198 µM -0.18862770265089 0.424507400192891 no 1968 0.425192309493781 2859 5799357 SGTC_2015 5119600 184 µM -0.189990933362664 0.423961945093838 no 1969 0.424658117630911 2905 2828786 SGTC_1960 st011366 51.8 µM -0.19077228015779 0.423649378647541 no 1970 0.424352003516508 2724 3972846 SGTC_2903 5923464 63.88 µM -0.191265218862212 0.423452210370879 no 1971 0.424158904671091 2825 2876576 SGTC_477 mead ethanolamide 10 µM -0.192047351315429 0.423139408171513 no 1972 0.423852557354404 2727 16061185 SGTC_1501 4491-0275 38.4 µM -0.192920975093758 0.422790072665768 no 1973 0.423510428927775 2743 5104718 SGTC_2769 toremifene 3.73 µM -0.193550295954463 0.422538464046915 no 1974 0.423264010089066 2931 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_133 0724-0033 378.92 µM -0.194370587517804 0.422210550934769 no 1975 0.422942859237458 2709 280309 SGTC_864 0469-0573 172 µM -0.196098904108953 0.421519829819765 no 1976 0.422266377001077 2731 689425 SGTC_454 lyso-paf C-16 6.67 µM -0.1962209273978 0.421471072354651 no 1977 0.422218624376584 2817 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1354 1498-1681 81 µM -0.196689961213638 0.421283669346455 no 1978 0.422035083215205 2830 5754243 SGTC_2122 5258151 111.688 µM -0.197250377828037 0.42105977761821 no 1979 0.42181580456601 2784 2173356 SGTC_590 k048-0076 22.4 µM -0.198991002560528 0.420364544685107 no 1980 0.421134891384673 2872 6832814 SGTC_932 2857-0803 154 µM -0.200362475045898 0.419816931803741 no 1981 0.420598552483267 2988 674898 SGTC_717 1532-0246 73.2 µM -0.20155155418527 0.419342272034436 no 1982 0.420133661002582 2844 9561992 SGTC_2234 tolnaftate 200 µM -0.202094615130709 0.41912553051833 no 1983 0.419921378758704 2793 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_605 1315-0399 119 µM -0.203890667363895 0.418408881726625 no 1984 0.419219469128926 2878 24020461 SGTC_556 4058-0063 51.5 µM -0.204178328604722 0.418294126148865 no 1985 0.419107072947254 2783 6615692 SGTC_575 k072-0246 11.9 µM -0.204245960261018 0.418267147125169 no 1986 0.419080648586818 2755 6796779 SGTC_2596 sinensetin 100 µM -0.205875608921772 0.417617178611937 no 1987 0.418444039287123 2832 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2600 tangeritin 87.95 µM -0.206005853710678 0.417565241511657 no 1988 0.418393169389559 2771 68077 A bioactive flavone. SGTC_3197 9113331 49.47 µM -0.207373997371616 0.417019760374328 no 1989 0.417858894149257 2974 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_609 0986-0026 86.3 µM -0.208311101107593 0.416646227656268 no 1990 0.41749303217015 2781 2848610 SGTC_221 trifluoperazine 10.304 µM -0.209015523825779 0.416365491902304 no 1991 0.41721806000196 2787 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2350 9023895 38.85 µM -0.211639277376846 0.415320215779904 no 1992 0.416194232220291 2928 2997209 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.211693253339442 0.415298718581115 no 1993 0.416173175937761 2771 229346 A bile salt which induces apoptosis. SGTC_1502 4534-4282 27.7 µM -0.211931524225833 0.415203824617864 no 1994 0.416080228195405 2806 3278949 SGTC_876 0720-0963 56.8 µM -0.212183726784962 0.415103387603635 no 1995 0.415981850921937 2984 765861 SGTC_1134 3477-0009 42.5 µM -0.212983208845159 0.414785038989006 no 1996 0.415670029808435 3050 3973534 SGTC_3163 9099914 49.47 µM -0.213418833741179 0.41461159949462 no 1997 0.415500145840181 2874 16268368 SGTC_151 3013-0144 2.285 µM -0.213816532716301 0.414453274342691 no 1998 0.415345065923055 3003 906558 YHR107C CDC12 SGTC_825 1988-2224 89.6 µM -0.214601264236758 0.414140911167593 no 1999 0.415039104090688 2779 1180859 SGTC_2147 5545932 89.7195 µM -0.214769132634855 0.41407409802615 no 2000 0.414973659952528 2813 797404 SGTC_3156 9099931 49.47 µM -0.214876447599564 0.414031387002054 no 2001 0.41493182403855 2780 18111053 SGTC_131 0141-0277 33.849 µM -0.215474970865352 0.413793195256495 no 2002 0.414698512051672 2956 1547771 SGTC_1453 4237-0541 195 µM -0.216234960364144 0.413490791195753 no 2003 0.41440230184008 2893 739892 SGTC_2210 7115885 190.385 µM -0.216354357559756 0.413443287044504 no 2004 0.414355770526801 2794 2927039 SGTC_3055 9094636 49.47 µM -0.219358779080689 0.412248347036733 no 2005 0.413185288783704 2961 25236176 SGTC_3004 9076122 71.4286 µM -0.21977893044868 0.412081305978116 no 2006 0.413021664758759 2936 44782551 SGTC_156 3474-0145 5.642 µM -0.220391050268013 0.411837971860463 no 2007 0.412783307461473 2723 2265471 SGTC_620 0109-0052 432 µM -0.221278506000769 0.411485244522197 no 2008 0.412437792454605 2921 493037 SGTC_3144 9087057 49.47 µM -0.22214498025146 0.411140925472074 no 2009 0.412100511667097 2777 17249618 SGTC_3243 9134147 49.47 µM -0.22263377732125 0.410946717745483 no 2010 0.411910272823823 2850 24282180 SGTC_67 0335-0847 266 µM -0.222745360025413 0.410902387020577 no 2011 0.411866847958896 3167 4552207 YOR254C SEC63 SGTC_1119 parthenolide 318.541 nM -0.222897333731794 0.410842011173151 no 2012 0.4118077057827 3000 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3124 9127567 49.47 µM -0.225878365493426 0.409658140914431 no 2013 0.410648012416179 3025 17592030 SGTC_2219 9098279 200 µM -0.227677168834523 0.408944171766069 no 2014 0.409948611472872 2818 902349 SGTC_394 menadione 8.33 µM -0.228073425903814 0.408786932536779 no 2015 0.409794579368516 2870 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1640 st009078 66.4 µM -0.228166752951839 0.408749901457024 no 2016 0.409758303525122 2947 690618 SGTC_2826 7992541 19.48 µM -0.230962417104316 0.407640993767086 no 2017 0.408671999742063 2752 2985066 SGTC_279 1273-0055 2.93 µM -0.231718038667831 0.407341401040438 no 2018 0.408378509918125 2881 2847562 SGTC_1491 4138-0063 26.5 µM -0.232707377677883 0.406949224772133 no 2019 0.407994319960796 2806 23883227 SGTC_851 0394-0702 453 µM -0.235089256558315 0.406005425836899 no 2020 0.407069728539947 2945 762646 SGTC_566 0958-0068 16.5 µM -0.235794476247038 0.405726093139612 no 2021 0.406796077318676 2994 6815365 SGTC_2929 9013348 24.6 µM -0.238803362895102 0.404534834620897 no 2022 0.405629031227258 2924 2995952 SGTC_482 fipronil 114 µM -0.240482780963117 0.403870314373244 no 2023 0.404978005227648 2810 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_3122 9126309 49.47 µM -0.240679632673058 0.403792441261822 no 2024 0.404901712889895 2851 17591206 SGTC_568 1193-0097 7.48 µM -0.240692569743788 0.4037873235838 no 2025 0.404896699093171 2931 3646150 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.24156358966089 0.403442801326814 no 2026 0.404559168921068 2889 77254 SGTC_232 clozapine 119 µM -0.241576045556232 0.403437875078442 no 2027 0.404554342633702 2814 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_567 1080-0542 68.4 µM -0.24167572381212 0.403398453346236 no 2028 0.40451572081029 2837 5950415 SGTC_1436 4092-1007 8.32 µM -0.242035943476895 0.403255998333648 no 2029 0.404376156100263 2855 2881121 SGTC_3204 9114183 49.47 µM -0.242829555879642 0.402942196089633 no 2030 0.404068719217353 2782 17027248 SGTC_2808 7946468 45.46 µM -0.24340528718513 0.402714585308269 no 2031 0.403845724187891 2921 2970879 SGTC_448 monastrol 171 µM -0.243496681722767 0.402678456236795 no 2032 0.403810327686342 2882 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2585 alliin 100 µM -0.244154404491174 0.402418477121865 no 2033 0.403555619245939 3043 87310 A garlic compound which reacts with lipids. SGTC_107 0358-0022 2.6945 µM -0.244443784385867 0.402304107138216 no 2034 0.40344356750031 2905 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.244672472084008 0.402213730104423 no 2035 0.403355022187077 3039 94937 An inhibitor of serotonin biosynthesis. SGTC_2061 5245884 80.95 µM -0.244721458669951 0.402194371359097 no 2036 0.403336055774256 2826 573863 SGTC_2418 pentamidine 31.67 µM -0.246183616951397 0.401616659542567 no 2037 0.402770048569702 2826 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.246310568971205 0.401566509787855 no 2038 0.402720914539752 2896 75037 A free radical scavenger. SGTC_2743 auranofin 4.32 µM -0.249211166176422 0.400421132427832 no 2039 0.401598721252404 2875 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3080 9117754 49.47 µM -0.250460205203843 0.399928179428561 no 2040 0.40111573787995 3057 9550191 SGTC_1658 st012944 20 µM -0.251454254078242 0.399535976214618 no 2041 0.400731463035422 2905 24207260 SGTC_2505 galangin 7.89 µM -0.252328926505108 0.399190956940489 no 2042 0.400393415610089 2803 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1607 st000305 50.6 µM -0.253104805739521 0.3988849730611 no 2043 0.400093612662215 2997 5457690 SGTC_1965 Pectolinarigenin 58.4 µM -0.256210353448393 0.397660860485402 no 2044 0.398894207248794 2859 5320438 An anti-inflammatory. SGTC_1068 loratadine 26.9 µM -0.257441467358797 0.397175870824169 no 2045 0.398418997496454 2907 3957 A H1 histamine antagonist. SGTC_2080 5212524 12.4 µM -0.257552233512808 0.397132242970362 no 2046 0.398376249154464 2908 260183 SGTC_2133 5320837 200 µM -0.257883628300475 0.397001723030799 no 2047 0.398248360170704 3018 2841355 SGTC_1691 st019933 84.6 µM -0.25818458767253 0.396883200083884 no 2048 0.398132226026107 2909 6176082 SGTC_1818 st052136 56.3 µM -0.258633290893325 0.396706510771921 no 2049 0.397959097272181 2955 674169 SGTC_1825 st052143 62.6 µM -0.258785776520813 0.396646470161785 no 2050 0.39790026641495 3034 674173 SGTC_2962 9082311 13.18 µM -0.258974765565508 0.396572059876766 no 2051 0.39782735530576 2841 16459453 SGTC_3161 9100388 49.47 µM -0.258994329774818 0.396564357114194 no 2052 0.397819807727057 2873 25236368 SGTC_1487 3970-0795 2.82 µM -0.25943741349362 0.396389918319341 no 2053 0.39764888291593 2948 3765103 SGTC_1226 3909-7979 35.4 µM -0.259677255517391 0.396295502931052 no 2054 0.397556369198327 2970 6615510 SGTC_1834 st055981 52.8 µM -0.25984742317695 0.396228519001904 no 2055 0.397490734308418 3009 471719 YDL150W RPC53 SGTC_1137 ixabepilone 100 µM -0.260729658233392 0.395881289649937 no 2056 0.39715049646968 2847 154225 A novel microtubule stabilizer. SGTC_2435 5706476 10.6 µM -0.260934865259158 0.395800536268187 no 2057 0.397071368684301 3022 5725375 SGTC_2671 danthron 100 µM -0.261072061151558 0.395746549225746 no 2058 0.397018468340483 2924 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1078 idebenone 36.1 µM -0.261456598340001 0.395595243218455 no 2059 0.396870207606585 2936 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_751 0833-0568 350 µM -0.262127901700745 0.395331139437117 no 2060 0.396611418105151 2940 6954252 SGTC_3167 9103034 49.47 µM -0.26271933904235 0.395098496324303 no 2061 0.396383454925897 2844 5127859 SGTC_278 4092-0821 23.9 µM -0.266413125385389 0.393646386815979 no 2062 0.394960528899268 2944 877900 SGTC_1670 st016595 4.04 µM -0.266713944553796 0.393528192921994 no 2063 0.394844708267213 2921 597879 SGTC_1962 st076595 64.5 µM -0.266807080948496 0.393491600988413 no 2064 0.394808851012509 2869 279619 SGTC_2923 7992654 58.14 µM -0.267473570084705 0.393229774579425 no 2065 0.394552280555632 2916 2985126 SGTC_3205 9113483 49.47 µM -0.268087898546374 0.392988481951051 no 2066 0.394315830281056 3069 17018033 SGTC_77 0828-0286 12.516 µM -0.268117761487894 0.39297675359258 no 2067 0.394304337257538 2842 745345 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.268536596992534 0.392812270562645 no 2068 0.394143154320484 2893 4174840 SGTC_222 nsc-310342 10.666 µM -0.268674909191238 0.392757957475019 no 2069 0.394089930801746 2933 432556 SGTC_875 0709-0210 25.7 µM -0.269557489616857 0.39241143084035 no 2070 0.393750354187032 2965 6251364 SGTC_1059 3448-6867 171 µM -0.269663956988026 0.392369634426517 no 2071 0.393709395863131 2849 3934407 SGTC_1877 wortmannin 25 µM -0.27029806915131 0.392120723662998 no 2072 0.393465475344225 3015 312145 A covalent inhibitor of PI 3-kinase. SGTC_2699 st077704 54.6 µM -0.270880064010128 0.391892309570834 no 2073 0.393241639298241 2933 645852 SGTC_593 1203-0218 61.7 µM -0.271594843993427 0.391611832609238 no 2074 0.392966782192118 3027 3666956 SGTC_1557 sumaresinolic acid 42.3 µM -0.273099510436572 0.391021591460374 no 2075 0.392388361521872 2883 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_514 4466-0038 2.65 nM -0.274476077033029 0.390481820268793 no 2076 0.391859392843923 2932 5722064 SGTC_1282 0886-0010 32.4 µM -0.275630194857253 0.390029436945757 no 2077 0.39141605777639 3052 2836211 YNL267W PIK1 SGTC_2690 usnic acid 100 µM -0.275711456377529 0.389997590207034 no 2078 0.391384847829217 3139 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2978 9011784 42.97 µM -0.276429212759832 0.389716330484189 no 2079 0.391109210977911 3023 2994934 SGTC_1255 0566-0045 221 µM -0.276979668804403 0.389500668118527 no 2080 0.390897858788113 3034 2788469 SGTC_2727 riluzole 51.77 µM -0.278207297763381 0.389019819819392 no 2081 0.390426616558265 2904 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2989 9073649 71.4286 µM -0.279367523824955 0.388565528644908 no 2082 0.389981395753032 2908 21367202 SGTC_2854 9024559 71.43 µM -0.279397219513447 0.388553903176101 no 2083 0.389970002332088 2992 3163529 SGTC_3272 9137413 49.47 µM -0.279468204067253 0.388526114067807 no 2084 0.389942767889395 2862 17614870 SGTC_458 nppb 133 µM -0.279784846797487 0.388402161387043 no 2085 0.389821289051924 3095 4549 A chloride channel blocker. SGTC_3171 9103192 49.47 µM -0.279861251803635 0.388372253652964 no 2086 0.389791978159072 2979 13018434 SGTC_1292 0kpi-0043 232 µM -0.280356834675305 0.388178280336709 no 2087 0.389601875258469 2938 3333905 SGTC_684 1140-0066 328 µM -0.281639765496095 0.387676265237777 no 2088 0.389109872745282 2961 6813534 SGTC_2611 pyromycin 23.93 µM -0.281742339070192 0.387636135950043 no 2089 0.389070543559694 2925 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1523 st012844 44.7 µM -0.28233183239076 0.387405535046605 no 2090 0.388844539630747 3015 4274103 SGTC_301 4119-0100 24.5 µM -0.282371350945873 0.387390077403159 no 2091 0.388829390084703 2925 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1689 st020265 53.493 µM -0.282484387380392 0.387345864300183 no 2092 0.38878605819218 3035 5758320 YPR016C TIF6 SGTC_2387 9077560 195.08 µM -0.282615208248234 0.387294696813071 no 2093 0.388735910462721 2904 5303272 SGTC_2567 aureobasidin a 60 nM -0.282654796806682 0.387279213071009 no 2094 0.388720735295705 3150 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3178 9107506 49.47 µM -0.283362356032826 0.387002505184632 no 2095 0.388449540908876 3046 8897194 SGTC_195 4234-0266 16.654 µM -0.283389162344691 0.386992023065975 no 2096 0.388439267612606 2937 2303354 SGTC_2097 5376186 200 µM -0.283896180812453 0.386793778284526 no 2097 0.388244971703261 3043 742755 SGTC_2055 5235184 200 µM -0.287295418981035 0.385465437546965 no 2098 0.386943065002775 3084 2836034 SGTC_962 1254-0300 21.5 µM -0.287386566735559 0.385429837602525 no 2099 0.386908172886491 2881 7340576 SGTC_3077 9117319 49.47 µM -0.288340088648494 0.385057474643712 no 2100 0.386543211633889 2890 17154678 SGTC_3228 9131799 49.47 µM -0.288801633866814 0.384877273151158 no 2101 0.386366590859238 2969 17015818 SGTC_2216 7189485 200 µM -0.28911765924169 0.384753901433447 no 2102 0.386245670137947 3024 731273 SGTC_3011 9081274 71.4286 µM -0.291072686285151 0.38399094708734 no 2103 0.385497864560038 2938 6625322 SGTC_1758 st042942 75.2445 µM -0.29306625313027 0.383213415217856 no 2104 0.384735755456789 2921 669317 SGTC_2239 6685329 187.64 µM -0.293298016272329 0.383123053300423 no 2105 0.384647184899361 3051 805680 SGTC_1316 1272-0050 65.9 µM -0.294345320712073 0.382714800102452 no 2106 0.384247022372954 2922 7340392 SGTC_3324 9138759 60.749 µM -0.29444078638628 0.382677592785721 no 2107 0.384210552206026 3058 45595710 SGTC_765 1319-0117 244 µM -0.294479169140837 0.382662633585114 no 2108 0.384195889366261 2908 3487746 YGL099W LSG1 SGTC_580 1123-0028 41 µM -0.294647777237351 0.382596922753005 no 2109 0.384131480280121 2906 1677248 YPR107C YTH1 SGTC_999 SEC7.066 22.7 µM -0.294768307143147 0.382549951277191 no 2110 0.384085439250179 2925 740511 YDR170C SEC7 SGTC_2047 4141938 200 µM -0.295692675271354 0.382189775052056 no 2111 0.383732395738361 2958 3807862 SGTC_168 3970-0862 530.542 µM -0.295761665645309 0.38216289732116 no 2112 0.383706050141107 3018 3135186 SGTC_2824 7998404 51.95 µM -0.296403631593107 0.381912823178745 no 2113 0.383460926131244 2903 837851 SGTC_809 3998-0021 90 µM -0.29652236423901 0.381866576954927 no 2114 0.383415595154861 3094 715485 SGTC_1908 st060353 56.5 µM -0.297227652835663 0.381591902658742 no 2115 0.383146355703192 3143 4227716 SGTC_1071 trifluoperazine 6.31 µM -0.298737102875953 0.381004248570793 no 2116 0.382570322511632 3080 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_658 3253-0951 102 µM -0.29888087947857 0.380948288229646 no 2117 0.38251546831013 2971 1184878 SGTC_3042 9091578 49.47 µM -0.301248321386263 0.380027197751517 no 2118 0.38161257250489 2988 25236497 SGTC_1569 carminic acid 40.6 µM -0.302205770971612 0.379654879783758 no 2119 0.381247602601335 3109 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1618 st003135 44.5 µM -0.302563146999484 0.379515937573118 no 2120 0.381111401591471 2960 1270615 SGTC_1991 st073000 8.92 µM -0.303859108073768 0.379012218795825 no 2121 0.380617616319531 3132 4301969 YIL048W NEO1 SGTC_3012 9080433 71.4286 µM -0.305230102974655 0.37847955917993 no 2122 0.380095453398911 3044 17688859 SGTC_1233 0325-0408 14.2 µM -0.305273347680396 0.378462761475288 no 2123 0.380078986586702 3047 12874 SGTC_1250 0485-0349 40.2 µM -0.306182180735287 0.378109793189193 no 2124 0.379732969512233 2961 6842794 YDL195W SEC31 SGTC_2922 7999257 32.47 µM -0.306515464281601 0.377980379574085 no 2125 0.379606103655736 2934 2988377 SGTC_1555 citronellol 128 µM -0.308559690576786 0.377186908906019 no 2126 0.378828243868789 3045 8842 A terpine precursor. SGTC_3059 1327-0034 3 µM -0.310022480059324 0.376619442034916 no 2127 0.378271930696753 2951 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_175 3793-3120 23.7 µM -0.310130528392216 0.376577536886836 no 2128 0.37823084884746 2955 5322297 SGTC_2646 retinol 96.75 µM -0.310457470703186 0.37645074540172 no 2129 0.378106548099488 3021 445354 A vitamin A analog and teratogen. SGTC_917 harmaline 728.087 nM -0.312817681829123 0.375535828231496 no 2130 0.377209590472892 3057 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_187 1488-2104 32.728 µM -0.314223053085151 0.374991379103476 no 2131 0.376675817465812 3020 2852859 SGTC_2241 6772625 37.8075 µM -0.316207325812762 0.374223084325512 no 2132 0.375922573811833 2929 2285411 SGTC_1900 st060200 72.8 µM -0.316402539106951 0.374147526200756 no 2133 0.375848494978805 2933 688945 SGTC_1978 st071761 42 µM -0.316806263005075 0.373991278512255 no 2134 0.375695305816734 2976 5147680 SGTC_2071 5230951 39.92 µM -0.317142534446906 0.373861151817852 no 2135 0.375567725796904 3035 1799272 SGTC_2408 sulbentine 18.36 µM -0.317449667367895 0.373742313394266 no 2136 0.375451212701137 2996 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1887 st057648 70.8 µM -0.318513646396843 0.373330722657183 no 2137 0.375047672458196 3095 688672 SGTC_1989 st071868 50.2 µM -0.318983275154615 0.37314909692026 no 2138 0.374869597660568 3098 16414057 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.321071612254038 0.372341788556407 no 2139 0.374078061231683 3101 6708760 SGTC_1553 gossypol 38.6 µM -0.323636579090133 0.37135099236746 no 2140 0.373106595526037 2947 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.324419169646533 0.371048862352253 no 2141 0.372810354305995 2902 4000243 SGTC_404 fumagillin 50 µM -0.325571524756659 0.370604124270101 no 2142 0.372374279641064 3034 12015870 A methionine aminopeptidase binder. SGTC_33 0986-0033 35.816 µM -0.325755768156162 0.370533033680852 no 2143 0.372304573336463 3004 2848082 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.326070352982509 0.370411660877806 no 2144 0.372185563570166 3155 688798 SGTC_2461 5755302 26.15 µM -0.326496655712671 0.370247205770758 no 2145 0.372024309575983 3120 2788904 SGTC_3064 1327-0027 10 µM -0.328202943239657 0.369589207720775 no 2146 0.371379111305661 2949 16000455 YPR107C YTH1 SGTC_3049 9092223 49.47 µM -0.329544752990769 0.369072031766386 no 2147 0.370871986601484 3083 8623917 SGTC_1906 st060206 94.7 µM -0.329586761541371 0.369055844161335 no 2148 0.370856113469686 3124 5133468 SGTC_2358 9037157 4 µM -0.330491557887042 0.368707245700567 no 2149 0.370514285226195 3069 2388925 SGTC_2375 9072683 200 µM -0.330968825303158 0.368523408381117 no 2150 0.370334016766398 3153 16798029 SGTC_2235 salicylic acid 500 µM -0.331875013109274 0.368174439232596 no 2151 0.369991819364817 3023 338 A COX inhibitor and kinase inhibitor. SGTC_2809 7964133 12.99 µM -0.334089290152682 0.367322188375383 no 2152 0.36915609072534 3025 1253665 SGTC_3293 9120939 62.045 µM -0.334452782512386 0.367182346471104 no 2153 0.36901895773641 3149 934087 SGTC_1308 1187-1617 41.4 µM -0.334750642939251 0.367067767457736 no 2154 0.368906597812954 2987 2882570 SGTC_2492 derrusnin 100 µM -0.334970592782399 0.366983166179721 no 2155 0.368823634774982 2923 1715307 Part of coumarin class of compounds. SGTC_2783 7738165 71.43 µM -0.335225053385413 0.366885298778316 no 2156 0.368727662225145 3050 17201110 SGTC_797 k781-0471 270 µM -0.335627702171708 0.366730454799739 no 2157 0.368575815637814 2995 23738129 SGTC_3027 9089541 49.47 µM -0.335715322473892 0.366696762112083 no 2158 0.368542775057398 3090 9943819 SGTC_1015 4130-4525 82 µM -0.337130694372617 0.366152650764866 no 2159 0.36800918984892 3010 1363237 SGTC_2336 9001819 198.65 µM -0.33954795124953 0.365224007401299 no 2160 0.367098490192946 3235 2989602 SGTC_1329 1447-1697 50.6 µM -0.340423517882466 0.364887833415709 no 2161 0.366768805228282 3096 2840515 SGTC_40 0327-0103 19.753 µM -0.340934421351366 0.364691719882335 no 2162 0.366576475536694 3012 409036 SGTC_1853 st056710 91.2 µM -0.34135118957513 0.36453176697532 no 2163 0.36641960787943 3157 269167 SGTC_2705 st078069 42.8 µM -0.342169254932008 0.364217867465537 no 2164 0.36611176065073 3075 1530061 SGTC_524 r073-0010 27.8 µM -0.342648641477256 0.364033964559869 no 2165 0.365931402108633 2980 2772106 SGTC_378 3970-0959 8.33 µM -0.343021730799386 0.363890861198681 no 2166 0.365791056033194 3135 6615653 SGTC_995 3931-2021 34.6 µM -0.343083769721547 0.363867067186739 no 2167 0.365767720415803 3110 730143 SGTC_290 2043-6722 48.1 µM -0.344006683047216 0.363513160938598 no 2168 0.365420630073234 3106 773758 YLR208W SEC13 SGTC_1564 D-Arginine 115 µM -0.344647592483764 0.363267462198264 no 2169 0.365179660897182 3055 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_959 1222-0044 107 µM -0.345295320907835 0.363019206482433 no 2170 0.364936181991707 3152 6083612 SGTC_2992 9074591 71.4286 µM -0.345839757114435 0.362810584217642 no 2171 0.364731572392406 3134 17741321 SGTC_1197 1601-0112 267 µM -0.345970323494135 0.362760558595831 no 2172 0.364682508760211 3003 7350313 SGTC_2178 5812956 200 µM -0.348932928778537 0.361626087553429 no 2173 0.363569831704216 2966 5403383 SGTC_2003 4023581 200 µM -0.352143611643793 0.3603979923006 no 2174 0.362365281532534 3161 16641307 SGTC_22 0964-0034 14.468 µM -0.352711419408018 0.360180953601629 no 2175 0.362152398728954 3085 138402 SGTC_1748 st037455 53.6035 µM -0.355645900940332 0.35905999764877 no 2176 0.361052882073571 3195 580690 SGTC_883 0850-0245 24.6 µM -0.355716216764399 0.359033152223297 no 2177 0.361026549575994 3209 6823229 YPR165W RHO1 SGTC_2670 beta-carotene 100 µM -0.356000677649157 0.358924556840343 no 2178 0.360920028847168 3130 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1924 st058459 75.1 µM -0.356357441908025 0.358788375140583 no 2179 0.360786448262633 3001 688683 SGTC_515 4092-1064 102 µM -0.357814270626117 0.358232470545621 no 2180 0.360241155147173 3244 717353 SGTC_916 4466-0038 42 nM -0.359503558818089 0.357588238939638 no 2181 0.359609207985539 3259 5722064 YGL116W CDC20 SGTC_283 0987-0079 11.7 µM -0.360979920598658 0.357025541545633 no 2182 0.359057228756972 3142 411556 SGTC_928 2764-0428 58.7 µM -0.361099550922114 0.356979959497508 no 2183 0.359012514474416 3146 662578 SGTC_120 rhodamine 6G 52.259 µM -0.361155866249882 0.356958502701564 no 2184 0.358991466136346 3010 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2521 angolensin 13.4 µM -0.361603492766162 0.35678796788079 no 2185 0.358824177105702 3190 821428 A flavenoid. SGTC_3158 9100007 49.47 µM -0.362574537551405 0.356418121842307 no 2186 0.358461366919224 3042 19297233 SGTC_2192 5915882 198.485 µM -0.362831466382011 0.356320286814804 no 2187 0.358365392292323 3062 2876149 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.362886316104795 0.356299402006034 no 2188 0.358344904579912 3103 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2588 indole-3-carbinol 100 µM -0.363629463357948 0.356016480668022 no 2189 0.3580673611259 3168 3712 Induces cell cycle arrest. SGTC_2349 9023730 187.07 µM -0.364253403156356 0.355779003642898 no 2190 0.357834396026094 3193 4126287 SGTC_2546 rhodinyl acetate 100 µM -0.36459239203839 0.355650004919363 no 2191 0.357707847384982 3185 6708682 SGTC_154 3389-1638 511.116 µM -0.366082123476333 0.355083299107108 no 2192 0.35715189821431 3109 5238686 SGTC_2553 4-methylesculetin 85.09 µM -0.367516328770522 0.354538018562158 no 2193 0.356616957070482 3110 5319502 SGTC_2971 9092186 9.93 µM -0.367685578756074 0.354473689861576 no 2194 0.356553847460123 3010 25236400 SGTC_2254 7938975 95.19 µM -0.368996705995091 0.353975496090709 no 2195 0.356065090016897 3223 2969277 SGTC_264 promethazine 12.5 mM -0.370753350759751 0.353308409204945 no 2196 0.355410624778428 3161 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3037 9091026 49.47 µM -0.370848968041069 0.353272111394021 no 2197 0.355375013290258 3150 25236398 YIL048W NEO1 SGTC_1108 betulinic acid 729.144 nM -0.372084122139043 0.352803347723857 no 2198 0.354915108848818 3094 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2946 9065502 71.43 µM -0.372172999498042 0.352769625740004 no 2199 0.354882023880023 3086 16489101 SGTC_973 1325-0077 65.9 µM -0.377061335402551 0.350916673833938 no 2200 0.353064011983394 3103 2835149 SGTC_84 0443-0269 128.823 µM -0.377551263983238 0.350731158032997 no 2201 0.352881987525314 3181 6150058 SGTC_2017 5132927 60.65 µM -0.378166969624847 0.350498066099133 no 2202 0.352653280529058 3058 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_3135 9127742 49.47 µM -0.379467910707083 0.350005745041378 no 2203 0.352170214538432 3119 3643468 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.379481210993338 0.350000713053586 no 2204 0.352165277100529 3154 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2328 6201408 200 µM -0.380652941862528 0.34955750761059 no 2205 0.351730395749977 3185 2890418 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.381541381539731 0.349221593238716 no 2206 0.351400785575147 3144 6708739 YPR165W RHO1 SGTC_2768 sulfasalazine 50.2 µM -0.381840316544573 0.349108594022242 no 2207 0.351289906112836 3216 5384001 An antioxidant and salicylic acid derivative. SGTC_2481 5478948 45.16 µM -0.383546684050399 0.348463833298932 no 2208 0.350657231449465 3222 77792 SGTC_2776 terbinafine 19.92 µM -0.384341378132223 0.348163702826034 no 2209 0.350362721680848 3140 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1951 sophoraflavanone G 9.2 µM -0.386332193364494 0.347412253499036 no 2210 0.349625330441522 3086 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_10 0279-0212 42.575 µM -0.387468820974692 0.34698349276729 no 2211 0.349204581490359 3098 39851 YBR002C RER2 SGTC_3300 9124615 50.48 µM -0.389004919298773 0.346404354206803 no 2212 0.348636253684999 3264 24824903 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.389374522699984 0.346265060143459 no 2213 0.348499557930711 3320 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_816 0325-0417 81.3 µM -0.389374780386156 0.346264963035387 no 2214 0.348499462633779 3151 68101 SGTC_2215 7188065 200 µM -0.389686002866216 0.346147687384151 no 2215 0.348384374003827 3194 940217 SGTC_1439 4092-1168 46 µM -0.390248333723864 0.345935825847766 no 2216 0.348176462058396 3161 2886240 SGTC_874 0599-0792 117 µM -0.390868079867322 0.345702388617635 no 2217 0.347947374668748 3250 765305 SGTC_2170 morpholine 200 µM -0.392463147238584 0.345101851073925 no 2218 0.347358017938735 3195 121171 Reacts with secondary amines. SGTC_2745 rifampicin 24.3 µM -0.393341047701533 0.344771490724589 no 2219 0.347033802370112 3136 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2153 5569715 200 µM -0.395097069730134 0.344111042076564 no 2220 0.34638562567033 3151 2054701 SGTC_5 0352-0601 109.883 µM -0.395763224264192 0.343860622257116 no 2221 0.34613985456728 3146 762456 SGTC_986 1493-0483 84 µM -0.395767332741215 0.343859078016934 no 2222 0.346138338986385 3214 40079 SGTC_643 k048-0106 28.4 µM -0.397825847946531 0.343085678548937 no 2223 0.345379281299156 3185 6763920 SGTC_164 4100-3994 89.624 µM -0.39815592233598 0.342961728171721 no 2224 0.345257627275753 3238 4615967 SGTC_2920 7982904 15.77 µM -0.399559331789342 0.342434905079521 no 2225 0.344740557631793 3170 6456808 SGTC_1677 st019204 53.9 µM -0.401791084889121 0.341597763092791 no 2226 0.343918891883347 3183 3945625 SGTC_827 3253-0474 693 µM -0.403263522031695 0.341045870392847 no 2227 0.343377186921095 3232 5402065 SGTC_2201 6605497 169.863 µM -0.404699614675877 0.34050792758407 no 2228 0.342849162727385 3141 670741 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.407070203605983 0.339620643764673 no 2229 0.341978213495097 3185 1241132 A phosphatase inhibitor. SGTC_2724 maprotiline 69.64 µM -0.408836589176312 0.338960083295213 no 2230 0.341329793220071 3250 4011 A tricyclic antidepressant. SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.410236258332029 0.33843701197376 no 2231 0.340816322746176 3296 23847180 SGTC_219 mitoxanthrone 164.414 µM -0.412969268601117 0.33741655571427 no 2232 0.339814564747472 3154 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_35 0133-0054 64.071 µM -0.413857564959374 0.337085138906189 no 2233 0.339489211490344 3154 99677 SGTC_1882 5615643 20 µM -0.415154406592279 0.336601523908396 no 2234 0.339014436552406 3208 2253075 SGTC_2397 5161689 200 µM -0.416157240951306 0.336227734538833 no 2235 0.338647473129126 3336 2259942 SGTC_1061 3448-9325 110 µM -0.416251204311041 0.336192719589692 no 2236 0.338613097309298 3213 723482 SGTC_3176 9106582 49.47 µM -0.417206488809514 0.335836818584137 no 2237 0.338263689702017 3183 17018027 SGTC_2396 5342950 42.78 µM -0.418440081897961 0.335377448624929 no 2238 0.33781269316293 3201 1886677 SGTC_2286 7945697 125 µM -0.418471599963204 0.335365715031493 no 2239 0.337801173335184 3185 1245733 SGTC_1779 st039427 55 µM -0.420905112550759 0.334460248898882 no 2240 0.336912185895173 3343 1124498 SGTC_257 daunorubicin 18.5 µM -0.423014325832699 0.333676226721449 no 2241 0.33614240446556 3252 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1819 st053448 58.6 µM -0.424008761626654 0.333306833443247 no 2242 0.335779711752879 3140 2857616 SGTC_346 4513-0042 7.16 µM -0.4241084128404 0.333269825890913 no 2243 0.335743375176402 3100 2827372 SGTC_46 0329-0187a 2.197 µM -0.424355732456525 0.333177985617525 no 2244 0.335653199788221 3220 46494817 SGTC_726 3448-4391 34.2 µM -0.425241407964854 0.332849178780947 no 2245 0.335330350644286 3339 1356692 SGTC_1008 4106-0037 6 µM -0.427503051559762 0.332010127607991 no 2246 0.334506481480419 3077 2905394 SGTC_2913 7966556 36.57 µM -0.431493751426872 0.330531665491482 no 2247 0.333054697534142 3290 2976516 SGTC_1407 3909-7909 12.3 µM -0.432240022181189 0.330255481816198 no 2248 0.332783486994104 3191 4411780 SGTC_2974 9094440 9.66 µM -0.432256132480577 0.330249520653637 no 2249 0.332777633135421 3316 25236134 SGTC_2255 7941087 197.44 µM -0.433798117526201 0.329679152123587 no 2250 0.332217524365515 3297 935561 SGTC_1189 1431-2119 7.28 µM -0.43380165595141 0.32967784374183 no 2251 0.332216239502554 3254 3107275 SGTC_1693 xanthone 101.9 µM -0.433976635798023 0.329613145119184 no 2252 0.332152703775695 3193 7020 An insecticide. SGTC_596 1155-0152 116 µM -0.434361856275775 0.329470728206239 no 2253 0.332012846025708 3200 280313 SGTC_3040 9091894 49.47 µM -0.43439451683257 0.329458654658943 no 2254 0.332000989393418 3135 25236966 SGTC_3349 9149703 23.001 µM -0.43572218345215 0.328968010050177 no 2255 0.331519154369089 3192 4910494 SGTC_3196 9111891 49.47 µM -0.435951355153097 0.328883348500006 no 2256 0.331436011858651 3208 18891510 SGTC_2168 5727979 200 µM -0.436014743046728 0.328859933033968 no 2257 0.331413016468948 3209 695210 SGTC_694 1315-0438 43.2 µM -0.436166537066329 0.328803863105842 no 2258 0.331357952344208 3185 6793154 SGTC_1420 4'-methoxyflavone 42 µM -0.436593280116811 0.328646252691696 no 2259 0.331203168463625 3248 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2145 5634607 200 µM -0.438886730409209 0.327799727774045 no 2260 0.330371806085905 3162 308662 SGTC_3065 9113888 49.47 µM -0.438973553803642 0.327767698131597 no 2261 0.330340349519874 3357 16648368 SGTC_2161 5662504 8.5105 µM -0.439977934362519 0.327397268610733 no 2262 0.329976544436418 3184 2859334 SGTC_3030 9087619 49.47 µM -0.441314609912944 0.326904547602688 no 2263 0.32949262534994 3208 25236973 SGTC_3001 9076041 71.4286 µM -0.445413734922344 0.325395425252717 no 2264 0.328010394108292 3186 16004211 SGTC_8 0354-0001 70 µM -0.445607178716775 0.325324277970557 no 2265 0.327940512067841 3210 4993152 SGTC_752 1896-0090 130 µM -0.44759460893298 0.324593684034537 no 2266 0.327222897299708 3222 772567 SGTC_1348 1493-0373 93.8 µM -0.44864218665003 0.324208858027765 no 2267 0.326844898045371 3231 3010129 SGTC_2424 5537928 59.2 µM -0.448683391622391 0.32419372528127 no 2268 0.326830033613224 3176 5382802 SGTC_1406 3909-7906 11.9 µM -0.449318604664041 0.323960476655906 no 2269 0.326600919326782 3248 X1406 SGTC_3223 9129970 49.47 µM -0.449707365672728 0.323817758675474 no 2270 0.326460729798419 3168 17248386 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.4501560595334 0.323653070954707 no 2271 0.326298958594171 3297 688662 SGTC_2167 5876490 200 µM -0.450543225701019 0.32351099398816 no 2272 0.326159396721296 3357 686534 SGTC_235 0330-0087 5 mM -0.451257052033453 0.323249111176339 no 2273 0.325902147413704 3242 46494818 YHR062C RPP1 SGTC_1554 st069299 38.7 µM -0.451584995613831 0.323128827243492 no 2274 0.325783990611404 3277 24207999 SGTC_3309 9129340 25.759 µM -0.45270908726154 0.322716670596551 no 2275 0.325379117579855 3228 17158987 SGTC_3094 9117742 49.47 µM -0.452928531788788 0.322636234994671 no 2276 0.325300102516837 3161 17149698 SGTC_1627 st003713 25.6 µM -0.453576590090121 0.322398742965573 no 2277 0.325066802984519 3262 16195070 YER133W GLC7 SGTC_1990 st072050 59.8 µM -0.453718361996454 0.322346797887014 no 2278 0.325015774554816 3189 17233948 SGTC_3048 9093155 49.47 µM -0.453762341276297 0.322330684629639 no 2279 0.324999945614601 3314 25236002 SGTC_1645 Cervolide 78 µM -0.454008612126301 0.322240461363384 no 2280 0.324911314108092 3251 23173 A fragrance. SGTC_316 k060-0003 58.6 µM -0.454225783722596 0.322160907526942 no 2281 0.324833163482809 3304 6152314 SGTC_2382 9035899 200 µM -0.455088084027377 0.321845111938046 no 2282 0.324522935154323 3206 6462679 SGTC_1997 st073024 93.8 µM -0.456126753795743 0.32146489631192 no 2283 0.324149416302904 3305 686268 SGTC_1594 piperine 70.1 µM -0.456644680665236 0.321275373754094 no 2284 0.323963229301935 3196 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2710 st078562 53.7235 µM -0.458378734652423 0.320641178402026 no 2285 0.323340183410715 3177 17250908 SGTC_3206 9114350 49.47 µM -0.458770317630556 0.320498037157132 no 2286 0.323199556043553 3284 17087243 SGTC_565 1418-0001 44.5 µM -0.461637793533182 0.319450659966675 no 2287 0.32217054367502 3352 2862145 SGTC_1018 4259-0013 28.1 µM -0.461755195349803 0.319407808264058 no 2288 0.322128442231798 3303 6801262 SGTC_3091 9116372 49.47 µM -0.461764156891316 0.319404537397456 no 2289 0.322125228628843 3351 17169793 SGTC_1704 st028805 70.8 µM -0.463530547083301 0.318760098552885 no 2290 0.321492062153374 3278 2876101 SGTC_873 0591-4978 488 µM -0.46443123691156 0.318431707160789 no 2291 0.321169407278937 3403 3305145 SGTC_3160 9100216 49.47 µM -0.465064812815255 0.318200790889787 no 2292 0.320942521684909 3280 17191039 SGTC_510 ag-490 170 µM -0.466506583486699 0.317675579246668 no 2293 0.320426468149542 3357 5328779 SGTC_43 0570-0105 72.5 µM -0.467815222396147 0.317199182566149 no 2294 0.319958366893288 3227 1114046 YDL195W SEC31 SGTC_939 1165-0479 45.3 µM -0.46863107901848 0.31690233141853 no 2295 0.319666679220142 3334 1377347 SGTC_320 4092-0846 5.34 µM -0.469447466800872 0.316605404944202 no 2296 0.319374913255203 3280 1359356 SGTC_1181 1222-0449 220 µM -0.46964892139625 0.316532152534851 no 2297 0.319302933296057 3374 658318 SGTC_918 glabranin 770.725 nM -0.469767479310333 0.316489046170029 no 2298 0.31926057559968 3270 124049 Also referred to as licorice root. SGTC_967 1306-0166 352 µM -0.469964040692488 0.316417584087338 no 2299 0.319190354466425 3346 4437607 SGTC_386 1509-0011 3.07 µM -0.470270315496879 0.316306248127607 no 2300 0.319080951376302 3254 3107280 SGTC_2340 7987427 183.45 µM -0.472497574736144 0.315497103839703 no 2301 0.318285836214284 3320 2239331 SGTC_2089 5281248 129.67 µM -0.473610231792267 0.31509321582012 no 2302 0.317888938894386 3285 2737878 SGTC_532 1548-0774 215 µM -0.478469642145267 0.313331873061313 no 2303 0.316157988187593 3452 5932993 SGTC_2821 7996764 71.43 µM -0.479243254443767 0.313051860470512 no 2304 0.315882793021646 3454 2987135 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.479482752616654 0.312965194829061 no 2305 0.31579761760899 3282 6708561 SGTC_143 4032-1194 15.74 µM -0.479710332489283 0.312882851560604 no 2306 0.315716689897248 3238 1806963 SGTC_2986 9022445 71.43 µM -0.481482465932871 0.312241975361386 no 2307 0.315086819328534 3358 6459286 SGTC_1556 plumbagin 1.48 µM -0.48252190277791 0.311866336326261 no 2308 0.314717621459895 3309 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1289 0976-0073 69.1 µM -0.484347557027783 0.311207042153087 no 2309 0.314069615116048 3346 3391136 SGTC_2427 5545055 42.75 µM -0.48488359338384 0.311013579463952 no 2310 0.31387946053668 3263 5372858 SGTC_427 1354-0053 47.3 µM -0.486567068124533 0.310406330601112 no 2311 0.313282582939486 3417 6813657 SGTC_1305 1181-0477 144 µM -0.487066704525971 0.310226205258243 no 2312 0.31310553035867 3372 6252086 SGTC_904 1141-0088 396 µM -0.487115140530362 0.310208745875835 no 2313 0.31308836872807 3288 1378119 SGTC_2308 7584454 197.62 µM -0.488529981491188 0.309698937094791 no 2314 0.312587247328468 3439 893577 SGTC_1562 morin hydrate 59.1 µM -0.48869217638154 0.309640516865776 no 2315 0.312529821756329 3392 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3106 9121286 49.47 µM -0.489616632570129 0.309307633106783 no 2316 0.312202602294002 3416 15943471 SGTC_2064 5220758 200 µM -0.492394441426878 0.308308325118248 no 2317 0.311220264024503 3406 788518 SGTC_1654 st012436 41.8 µM -0.492829754017476 0.308151851198101 no 2318 0.311066442577685 3344 4323132 SGTC_2110 5483698 200 µM -0.494564739692007 0.307528553942549 no 2319 0.310453698521729 3280 2848765 YHR062C RPP1 SGTC_1060 3448-7350 82 µM -0.494979848310537 0.307379507553327 no 2320 0.310307172671158 3369 570178 SGTC_1844 rapamycin 4 nM -0.496267750848633 0.306917283549114 no 2321 0.309852757990839 3295 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_1283 0922-0125 16.4 µM -0.496657551427688 0.306777445836596 no 2322 0.309715280644089 3317 3360884 SGTC_1842 st055362 61.2 µM -0.496945546066924 0.306674148215534 no 2323 0.309613725957149 3266 676032 SGTC_2630 antimycin a 100 µM -0.49723524572588 0.306570254529577 no 2324 0.30951158469677 3268 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2835 9006588 71.43 µM -0.498871923402499 0.305983592311452 no 2325 0.308934807324475 3415 2345538 SGTC_1140 3229-1848 2.98 µM -0.499076851241125 0.305910171546611 no 2326 0.308862622368633 3360 2849525 SGTC_2103 5378138 10 µM -0.499343100703048 0.305814792352959 no 2327 0.308768848159657 3406 244142 SGTC_1921 5740136 50 µM -0.49967556783057 0.305695710333933 no 2328 0.308651769306495 3401 1774243 SGTC_1027 k015-0025 8.67 µM -0.500001963782504 0.30557882285479 no 2329 0.308536847346597 3311 3598955 SGTC_1485 3909-9022 254 µM -0.500197363382529 0.305508856691055 no 2330 0.308468057351003 3358 714516 SGTC_2010 4012422 159 µM -0.500935464348611 0.305244631135704 no 2331 0.308208271222951 3298 952393 SGTC_3342 9147791 14.508 µM -0.502530228936979 0.30467408348389 no 2332 0.30764729704625 3324 1838168 SGTC_1495 4469-0029 237 µM -0.504408671768408 0.304002655256164 no 2333 0.306987112742083 3350 793680 SGTC_1724 st037281 8.293 µM -0.505268393268805 0.30369557769177 no 2334 0.306685169526464 3285 574124 YDL195W SEC31 SGTC_3231 9132313 49.47 µM -0.505710001087014 0.303537896900597 no 2335 0.306530123193345 3329 4905967 SGTC_2311 7694451 200 µM -0.506140308452408 0.303384286236859 no 2336 0.306379077697787 3289 2163142 SGTC_1685 st024049 53.0905 µM -0.507012013039881 0.303073212575392 no 2337 0.306073194803402 3347 1941139 SGTC_83 0170-0301 39.027 µM -0.507627483560243 0.302853663746475 no 2338 0.305857306353075 3345 3089716 SGTC_411 enrofloxacin 100 µM -0.50772895466712 0.302817474111218 no 2339 0.305821719830884 3442 71188 A bacterial gyrase inhibitor. SGTC_1478 0453-0656 35.7 µM -0.508439078505485 0.302564262904698 no 2340 0.305572726492579 3390 5258496 SGTC_3281 9140613 49.47 µM -0.508573630845719 0.302516295827766 no 2341 0.305525558035832 3333 16013766 SGTC_3354 9151612 71.43 µM -0.509754493776304 0.302095471828365 no 2342 0.305111735117063 3392 27261949 SGTC_2455 5377712 9.75 µM -0.509839205466692 0.302065293238482 no 2343 0.305082058225952 3342 2243908 SGTC_1167 k781-0610 148 µM -0.510442121786937 0.301850543059204 no 2344 0.304870876690336 3310 4525169 SGTC_2398 5228213 48.84 µM -0.512876700367707 0.300984079736525 no 2345 0.304018786344343 3452 80771 YMR134W ERG29 SGTC_1166 k206-0078 225 µM -0.51339606379591 0.300799384189814 no 2346 0.303837149220752 3367 5404595 SGTC_1975 st070967 30.8 µM -0.513662572675434 0.30070462840114 no 2347 0.303743961790285 3426 261391 SGTC_3287 9117173 37.0625 µM -0.514171650666034 0.300523665931886 no 2348 0.303565993162206 3312 2789709 SGTC_389 tpck 16.7 µM -0.514559484064785 0.300385835415231 no 2349 0.303430441700896 3360 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1087 pterostilbene 9.05 µM -0.515916430995157 0.299903820571896 no 2350 0.30295638881693 3409 5281727 Similar to reservatol, lowers cholesterol. SGTC_599 1935-0052 86.5 µM -0.516626810797262 0.299651619071269 no 2351 0.302708348074255 3280 9557311 SGTC_2376 9072922 81.32 µM -0.51717404520276 0.299457403558848 no 2352 0.302517334275296 3417 17087968 SGTC_1817 st052116 64.4 µM -0.517429664967494 0.299366702719034 no 2353 0.302428127953744 3409 4361398 SGTC_505 gw-5074 63.9 µM -0.51774613090085 0.299254429268625 no 2354 0.302317703849234 3401 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_784 4579-0127 173 µM -0.520182240986107 0.298390804408293 no 2355 0.301468280937301 3458 1948547 SGTC_2688 kanamycin b 96.69 µM -0.520699949860399 0.298207417793951 no 2356 0.301287904667424 3504 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_616 4092-0450 108 µM -0.520922487649561 0.298128604612238 no 2357 0.301210384647188 3366 787165 SGTC_116 0155-0182 31.788 µM -0.523765251800726 0.297122657469229 no 2358 0.300220912305048 3318 771486 SGTC_1749 st037932 54.2 µM -0.524732605633018 0.296780701634817 no 2359 0.299884543798503 3404 594497 SGTC_1579 chlormadinone acetate 49.4 µM -0.525011722622557 0.296682068361015 no 2360 0.29978752089382 3429 45114258 A steroidal progestin. SGTC_1322 1348-1070 12 µM -0.525204397442514 0.296613990443156 no 2361 0.299720554150651 3414 6758089 SGTC_1426 4048-4480 71.7 µM -0.526257731340181 0.296241941852359 no 2362 0.299354573519743 3415 14224343 SGTC_1520 flindersine 88 µM -0.527893966877961 0.295664431174107 no 2363 0.298786466174242 3498 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3050 9093513 49.47 µM -0.529149392517362 0.295221678788532 no 2364 0.298350909995828 3409 25236664 SGTC_385 1494-0393 12.4 µM -0.530957837730534 0.294584429417961 no 2365 0.297723998291533 3349 3090647 SGTC_1314 1222-0010 41.1 µM -0.53604777765514 0.292794281837631 no 2366 0.295962765348652 3372 3526027 SGTC_2490 carminic acid 95.39 µM -0.53925365625962 0.291669363235852 no 2367 0.294855920815588 3414 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2196 6573537 42.6665 µM -0.539796041842054 0.291479243656928 no 2368 0.294668848532649 3464 2903087 SGTC_2934 9036370 36.88 µM -0.539921697288304 0.2914352065594 no 2369 0.294625516971063 3380 6462800 SGTC_2738 aclarubicin 5.55 µM -0.539964164933405 0.291420324087504 no 2370 0.294610872911297 3331 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_88 0180-0332 8.668 µM -0.540609251635399 0.291194301837844 no 2371 0.294388469851491 3360 3101745 SGTC_3248 9135562 49.47 µM -0.543822354393757 0.29006973194238 no 2372 0.29328186212211 3415 17650701 SGTC_2628 lathosterol 100 µM -0.546172602279059 0.289248448162492 no 2373 0.292473648615888 3475 6710616 SGTC_2683 piperine 63.03 µM -0.547298029534236 0.288855559949394 no 2374 0.292086998689031 3355 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2370 9071495 200 µM -0.548534113039705 0.288424331149369 no 2375 0.291662606242557 3393 21791103 SGTC_626 0214-0009 33 µM -0.551252378317537 0.287477086906846 no 2376 0.290730339338413 3456 3437874 SGTC_1171 0368-0077 21.4 µM -0.556044988254527 0.28581058066865 no 2377 0.289090050239846 3380 3239779 SGTC_835 0312-0010 67.2 µM -0.55623927881459 0.285743118161878 no 2378 0.289023645449329 3393 1626196 SGTC_2674 ligustilide 100 µM -0.556311755154962 0.285717954516796 no 2379 0.288998876262598 3426 5319022 A signalling regulator. SGTC_543 3844-1095 191 µM -0.556814127477428 0.28554356080367 no 2380 0.288827215223635 3428 4230703 SGTC_2875 9039966 71.43 µM -0.558105006441327 0.285095677117981 no 2381 0.288386341070696 3412 6463691 SGTC_824 1304-0008 100 µM -0.559286990208267 0.284685869677038 no 2382 0.287982936368525 3408 768245 SGTC_1377 2944-0135 198 µM -0.560062086701576 0.284417287510284 no 2383 0.287718544809036 3437 1894137 SGTC_2148 5546263 113.568 µM -0.560425120874128 0.284291532554189 no 2384 0.287594750426447 3365 792097 SGTC_2452 5863136 48.41 µM -0.560959085735965 0.284106615554225 no 2385 0.287412714570879 3415 2184096 SGTC_2736 butenafine 14.65 µM -0.561294812634356 0.283990379669212 no 2386 0.287298288635161 3391 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_989 1501-0895 10.3 µM -0.562596706141418 0.283539851418903 no 2387 0.286854767734247 3486 2830112 SGTC_1230 0170-0365 3.77 µM -0.56268117604586 0.283510631924961 no 2388 0.286826002270617 3544 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2856 9022925 19.48 µM -0.564236932213037 0.282972729137603 no 2389 0.286296448170086 3444 4944862 SGTC_673 1082-0474 110 µM -0.564504594377552 0.282880234351299 no 2390 0.286205387144675 3435 3098046 SGTC_768 0384-0033 77.3 µM -0.564612026323558 0.282843113670345 no 2391 0.286168841719569 3360 3965305 YMR134W ERG29 SGTC_1799 st045822 46.1415 µM -0.565099908922172 0.28267456630889 no 2392 0.286002905228993 3472 3674992 SGTC_2124 5246320 200 µM -0.565763695552967 0.282445327438034 no 2393 0.285777214489801 3448 579342 SGTC_2090 5301565 104.445 µM -0.566497683956326 0.282191948505544 no 2394 0.285527753461985 3435 2056344 SGTC_2160 5660466 132.927 µM -0.567893743637757 0.281710319203803 no 2395 0.28505356020347 3458 2859134 SGTC_2784 7567673 72.73 µM -0.568321447240303 0.281562844262017 no 2396 0.284908359233892 3506 3471247 SGTC_754 3474-0146 171 µM -0.568586327788874 0.281471530427796 no 2397 0.28481845270903 3320 24762078 SGTC_1503 4585-0012 61.3 µM -0.569234175991848 0.281248254122203 no 2398 0.284598615254142 3505 2922052 SGTC_481 bay k-8644 50 µM -0.569571250326753 0.281132117665784 no 2399 0.284484266248682 3417 2303 A calcium channel antagonist. SGTC_811 0416-0114 265 µM -0.569918014265094 0.281012666905704 no 2400 0.284366653051997 3476 6612453 SGTC_186 3455-3465 67.277 µM -0.57075745745514 0.280723603107165 no 2401 0.284082032276035 3441 755278 SGTC_508 roscovitine 141 µM -0.570959521761344 0.280654043374989 no 2402 0.284013540906006 3464 160355 A CDKinase inhibitor. SGTC_36 0335-0881 14.2 µM -0.571261431604244 0.280550127803107 no 2403 0.283911220787515 3430 23828853 SGTC_1447 4239-0816 81.9 µM -0.571539790912495 0.280454334685937 no 2404 0.283816897803749 3403 1341554 SGTC_594 1487-1584 10.8 µM -0.57164020625711 0.280419782160736 no 2405 0.28378287541047 3378 5013332 SGTC_902 1120-0002 2.07 µM -0.572832688989177 0.280009611181401 no 2406 0.283378991739577 3478 3280475 SGTC_2128 5255449 168.493 µM -0.573942069473508 0.27962828571632 no 2407 0.283003501714935 3430 736008 SGTC_1029 k015-0030 64.7 µM -0.574159733792333 0.279553497920648 no 2408 0.282929857300496 3470 2208316 SGTC_2755 lomerizine 42.69 µM -0.574361063447636 0.279484331237028 no 2409 0.28286174773923 3433 3949 A calcium channel blocker. SGTC_3297 9117502 71.43 µM -0.576620135949622 0.278708798527992 no 2410 0.282098046839444 3475 7453720 SGTC_741 4582-0002 126 µM -0.576964223452168 0.278590766340859 no 2411 0.281981811973901 3439 2912688 SGTC_1260 0700-1617 7.75 µM -0.577205841226216 0.278507898852194 no 2412 0.28190020579921 3465 2853078 SGTC_469 w7 172 µM -0.577332301042403 0.278464531800027 no 2413 0.281857498652555 3486 45115570 A P450 inhibitor. SGTC_1204 4049-0315 18.3 µM -0.581305746725174 0.27710359053232 no 2414 0.280517204090214 3545 588402 SGTC_3230 9131665 49.47 µM -0.583274993912973 0.276430313885144 no 2415 0.279854096713538 3429 15943720 SGTC_941 3237-0776 460 µM -0.583930296715164 0.276206446874193 no 2416 0.279633604395948 3529 760008 SGTC_1883 5-benzylidenerhodanine 20 µM -0.584341479238184 0.27606602259709 no 2417 0.279495295258645 3475 1273210 SGTC_3271 9137798 49.47 µM -0.584569518824311 0.275988159171887 no 2418 0.279418604087912 3459 6498326 SGTC_3216 9129716 49.47 µM -0.585125028212269 0.275798527325284 no 2419 0.279231825517346 3433 8056934 SGTC_2667 digitoxin 100 µM -0.585186707167168 0.275777476196059 no 2420 0.279211090984637 3465 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2516 gossypol 71.55 µM -0.585596500024278 0.275637633271457 no 2421 0.27907335046773 3536 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3257 9139206 32.98 µM -0.586233154317323 0.275420442448265 no 2422 0.278859422328522 3478 4910041 SGTC_496 calpeptin 138 µM -0.587608787308992 0.274951441148038 no 2423 0.278397455742489 3468 73364 A calpain inhibitor. SGTC_356 1634-0012 32.5 µM -0.587883936378822 0.274857680474507 no 2424 0.278305099657526 3512 735457 SGTC_1206 3978-0017 132 µM -0.588572904715585 0.274622974584582 no 2425 0.27807390721896 3561 3873677 SGTC_2740 felodipine 17.08 µM -0.588867884332557 0.274522516230731 no 2426 0.277974951558873 3464 3333 L-type calcium channel blocker SGTC_2862 9027634 71.43 µM -0.589771159881105 0.274215009231678 no 2427 0.277672040159996 3450 5012562 SGTC_1988 st071872 53.4 µM -0.589991952249352 0.274139869568852 no 2428 0.277598022472113 3530 16414116 SGTC_453 enantio-paf c16 10 µM -0.590870323553762 0.273841044578471 no 2429 0.277303655738346 3511 13871343 A lipid and platelet activating factor SGTC_321 4534-3890 65.3 µM -0.591880051471853 0.273497730719269 no 2430 0.276965456454647 3494 699746 SGTC_3328 9140624 29.0385 µM -0.592205006118857 0.273387289423076 no 2431 0.276856658785501 3523 4904392 SGTC_3007 9078383 71.4286 µM -0.592667213905357 0.273230238395043 no 2432 0.276701943627946 3456 6496995 SGTC_1917 st066507 28.5 µM -0.59358987463775 0.272916866331035 no 2433 0.27639322745977 3416 3156428 SGTC_1089 terbinafine 2.25 µM -0.593677001050189 0.272887283968976 no 2434 0.27636408427118 3513 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_922 1866-0035 480 µM -0.593945497620657 0.272796130310309 no 2435 0.276274283487172 3489 3156169 SGTC_2925 9010536 32.5 µM -0.594234805797892 0.272697928092531 no 2436 0.276177538125679 3473 2994177 SGTC_913 3487-1245 167 µM -0.594571392502462 0.272583699822661 no 2437 0.276065003638949 3439 4016153 SGTC_2647 atorvastatin 60.16 µM -0.595233042436681 0.272359223294371 no 2438 0.275843853076714 3497 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_3284 9108171 64.8615 µM -0.596675416895427 0.271870190578983 no 2439 0.275362054250835 3457 8687505 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.596682614365197 0.271867751394385 no 2440 0.275359651106339 3534 1273210 SGTC_3132 9126706 49.47 µM -0.597700638137921 0.271522858219224 no 2441 0.275019849794789 3550 850858 SGTC_1374 2889-5571 141 µM -0.599492161695 0.270916443070154 no 2442 0.274422367744496 3465 2853281 SGTC_1657 st012939 43.4 µM -0.600970963489467 0.270416391197894 no 2443 0.273929663105648 3538 24207257 SGTC_1081 sertraline 6 µM -0.601377193162472 0.270279106801172 no 2444 0.273794392802401 3533 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2262 9014885 67.46 µM -0.601705032495216 0.270168339656998 no 2445 0.273685249768687 3468 6457424 SGTC_2756 carbadox 75.1 µM -0.602377604198265 0.269941168806193 no 2446 0.273461407128078 3488 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2793 7325131 81.82 µM -0.602900925796779 0.269764475503163 no 2447 0.273287300032123 3454 4176441 SGTC_465 cgp-37157 41 µM -0.603300770030463 0.269629511904198 no 2448 0.273154310395953 3446 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2987 9018338 71.43 µM -0.603539233225926 0.269549037038399 no 2449 0.273075011944733 3564 5055682 SGTC_3313 9133968 57.047 µM -0.604861503442446 0.269103025194442 no 2450 0.272635511918283 3502 1494643 SGTC_2653 dihydrofissinolide 100 µM -0.605086499390585 0.269027169227287 no 2451 0.27256076207707 3534 6857746 SGTC_664 1222-0054 14.9 µM -0.605434356149254 0.268909912638277 no 2452 0.272445214524834 3534 6813991 SGTC_1647 st011722 22.4 µM -0.607016351750408 0.268376972785695 no 2453 0.271920030261539 3539 2854783 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.608947851621024 0.267727013529079 no 2454 0.271279502562769 3458 803109 SGTC_628 1636-0253 16 µM -0.609240431323868 0.267628628233719 no 2455 0.271182542347173 3504 4456143 SGTC_3237 9133362 49.47 µM -0.609543330295418 0.267526792098369 no 2456 0.271082180557399 3504 43845137 SGTC_672 1441-0018 53.7 µM -0.609722327583706 0.267466621509053 no 2457 0.271022880751702 3498 251141 SGTC_2952 9073731 13.78 µM -0.609774584611642 0.267449056406291 no 2458 0.271005569801436 3484 16457353 SGTC_3053 9095903 49.47 µM -0.612034918586623 0.266689849841321 no 2459 0.270257327480869 3554 17174018 SGTC_254 nsc-64875 3.808 µM -0.612065187185278 0.266679690546582 no 2460 0.270247314626942 3554 56993 SGTC_2365 9042475 200 µM -0.613723197390711 0.266123498196605 no 2461 0.269699128300588 3520 6464479 SGTC_1572 epiandrosterone 68.9 µM -0.614654115577146 0.265811472180598 no 2462 0.269391584047995 3522 441302 A steroid. SGTC_2739 tacrine 100.86 µM -0.615508031253894 0.265525419083229 no 2463 0.269109633545007 3541 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3051 9093778 49.47 µM -0.616084395911983 0.265332431076762 no 2464 0.268919410079137 3527 17217378 SGTC_2860 9025725 38.96 µM -0.616255017704689 0.265275314309653 no 2465 0.268863110994256 3431 40546248 SGTC_727 3032-0951 202 µM -0.61733047267035 0.264915442412435 no 2466 0.268508385630597 3490 3652836 SGTC_608 k048-0125 159 µM -0.618653127489578 0.264473192242574 no 2467 0.268072447334021 3579 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2906 7926292 26.41 µM -0.619135203362141 0.264312096167034 no 2468 0.267913646947878 3547 2966319 SGTC_2879 9041815 71.43 µM -0.619190098099512 0.264293755072636 no 2469 0.267895567103308 3509 4942971 SGTC_1458 k015-0034 6.33 µM -0.619317601145291 0.264251157034404 no 2470 0.26785357573612 3506 3598957 SGTC_430 0958-0115 16.4 µM -0.620474407442746 0.263864834493728 no 2471 0.267472749118517 3470 6833180 SGTC_1500 4488-1866 171 µM -0.621227824581447 0.26361338115657 no 2472 0.26722486721392 3615 2900003 SGTC_2556 citropten 84.59 µM -0.623157994484916 0.262969744294769 no 2473 0.266590351105616 3486 2775 A potential DNA crosslinker. SGTC_2623 humulene 100 µM -0.623899927723497 0.262722552227235 no 2474 0.266346653890204 3513 6187145 An anti-inflammatory. SGTC_191 3914-0123 66.505 µM -0.628565217953979 0.261170932150572 no 2475 0.264816868672819 3446 3144412 SGTC_1269 0831-0796 3.05 µM -0.629200498377595 0.260960010323344 no 2476 0.264608901312595 3565 927758 SGTC_1338 1486-1223 76 µM -0.629796514736336 0.260762204376377 no 2477 0.264413863122267 3547 3444526 SGTC_2914 7968218 45.32 µM -0.630328673123521 0.260585656830725 no 2478 0.264239783431227 3526 2977111 SGTC_66 0109-0187 42.4 µM -0.63067226802261 0.260471699339987 no 2479 0.264127417657527 3593 759417 SGTC_1767 st044992 70.3 µM -0.630941185063623 0.260382527589386 no 2480 0.264039490753243 3517 9600693 SGTC_402 epigallocatechin gallate 10 µM -0.632613724149693 0.259828273975644 no 2481 0.263492961309956 3525 65064 An antioxidant. SGTC_3277 9138724 49.47 µM -0.63617653734002 0.258649645385902 no 2482 0.262330681982516 3486 15943418 SGTC_2218 6965428 192.983 µM -0.636218464493404 0.258635791792157 no 2483 0.262317019938121 3551 675684 SGTC_3210 9128157 49.47 µM -0.636262899436422 0.25862110999248 no 2484 0.262302541123377 3492 17590849 SGTC_662 k832-1615 104 µM -0.637356580031537 0.25825988181866 no 2485 0.261946302037628 3551 5878478 SGTC_655 k060-0012 42 µM -0.637403461480593 0.25824440334596 no 2486 0.261931037125404 3509 5994525 SGTC_1080 nisoldipine 24.4 µM -0.637528807605762 0.258203021180961 no 2487 0.261890225832005 3540 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1950 st077106 7.18 µM -0.639651453882597 0.257502766408236 no 2488 0.261199611518365 3535 13831864 SGTC_466 geldanamycin 89.2 µM -0.639811936831366 0.257449863694544 no 2489 0.261147435610987 3485 5288382 HSP90 inhibitor. SGTC_985 1493-0307 8.71 µM -0.63991352930764 0.257416376964044 no 2490 0.261114408829652 3573 3278274 SGTC_2019 4016004 108 µM -0.63999831108476 0.257388433078615 no 2491 0.26108684869577 3539 45595336 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.640493883733115 0.257225124974552 no 2492 0.260925782104892 3539 2724278 An inhibitor of dopamine biosynthesis. SGTC_200 k038-0079 37.545 µM -0.641690824095703 0.256830914546616 no 2493 0.260536974119697 3537 3436683 SGTC_265 mycophenolic acid 32.932 µM -0.641776155391509 0.256802822830372 no 2494 0.260509266933502 3681 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1772 st048439 82.2 µM -0.641871648964086 0.256771387511199 no 2495 0.260478261841528 3555 2927068 YDL195W SEC31 SGTC_766 1391-0721 126 µM -0.643948487989338 0.256088213261929 no 2496 0.259804418939521 3601 1020919 YIL115C NUP159 SGTC_2902 5787006 60.46 µM -0.644510517641042 0.255903497262735 no 2497 0.259622219803573 3549 591003 SGTC_2341 7987486 176.74 µM -0.645896591176367 0.255448249326233 no 2498 0.259173163696104 3596 1258686 SGTC_2828 7998861 71.43 µM -0.647600027682909 0.254889345498138 no 2499 0.258621839688096 3524 2988188 SGTC_3312 9133330 71.43 µM -0.647689908576177 0.254859873029541 no 2500 0.258592766253698 3615 17617324 SGTC_2750 bromebric acid 70.15 µM -0.649842780818822 0.254154467061623 no 2501 0.25789689085021 3608 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_737 1950-0117 57.9 µM -0.652122808623003 0.253408515538976 no 2502 0.257160975602772 3581 5393513 SGTC_362 0310-0100 9.03 µM -0.652529499693484 0.253275580377393 no 2503 0.257029824434553 3611 790235 SGTC_1062 mesoridazine 14.2 µM -0.652713162732933 0.253215558436627 no 2504 0.256970607536788 3606 4078 A neuroleptic. SGTC_2466 5983409 37.09 µM -0.654517400291879 0.252626323047308 no 2505 0.256389260261924 3549 2879657 SGTC_2843 9000894 45.46 µM -0.654723107917787 0.25255918809361 no 2506 0.256323022316252 3473 2242070 SGTC_1489 4065-0444 182 µM -0.657276843511675 0.251726531559125 no 2507 0.255501461608931 3579 2877968 SGTC_1001 4048-4355 44.4 µM -0.65840112662114 0.251360414310748 no 2508 0.255140205826051 3602 21824233 SGTC_778 3456-2434 196 µM -0.658710677904813 0.251259659904876 no 2509 0.255040787416508 3642 5539063 SGTC_1613 st002381 52.1 µM -0.658717917746239 0.251257303698195 no 2510 0.255038462443319 3610 551167 SGTC_379 3970-0972 5.9 µM -0.659086938792845 0.251137221260194 no 2511 0.254919971214683 3602 2898042 YBL034C STU1 SGTC_400 oxethazaine 37.5 µM -0.660385654430084 0.250714850201803 no 2512 0.254503187873903 3575 4621 A local anesthetic. SGTC_1754 st042065 16.137 µM -0.660818809287352 0.250574062362468 no 2513 0.254364259415885 3576 1126236 YIL048W NEO1 SGTC_3014 9081533 49.47 µM -0.662585974903435 0.250000116776186 no 2514 0.253797877529853 3620 21367265 SGTC_2347 9049783 174.81 µM -0.66711312751181 0.248532962446421 no 2515 0.252349937747931 3620 6467988 YPL169C MEX67 SGTC_468 gf-109203x 121 µM -0.667559254972718 0.248388630700051 no 2516 0.252207486850043 3548 2396 A protein kinase C inhibitor. SGTC_63 0099-0242 26.702 µM -0.667624180944121 0.248367629488548 no 2517 0.252186759173566 3618 3898502 YLR359W ADE13 SGTC_1940 st075990 51.1 µM -0.667827835173855 0.248301760827113 no 2518 0.252121748201385 3722 1084979 SGTC_1753 st043925 64 µM -0.667995060142028 0.248247681584366 no 2519 0.252068372872364 3626 670181 SGTC_861 0443-0273 110 µM -0.668219048552728 0.248175255330785 no 2520 0.251996888971602 3625 6149169 SGTC_2638 epoxomicin 18 µM -0.669375208019927 0.247801592506042 no 2521 0.25162808117802 3612 9915668 A protesome inhibitor. SGTC_1590 st077108 57.8 µM -0.66969608104068 0.247697941815575 no 2522 0.251525775216547 3597 5489485 SGTC_3268 9137683 49.47 µM -0.670154550429832 0.24754988394894 no 2523 0.25137963668412 3632 1953228 SGTC_1460 k062-0059 9.15 µM -0.670687812249615 0.247377732150797 no 2524 0.251209714311224 3557 1373085 SGTC_1729 st035615 45.989 µM -0.671258051224771 0.247193713917627 no 2525 0.251028076501211 3593 17385451 SGTC_1622 st003707 19.4 µM -0.671295148753159 0.247181744944149 no 2526 0.251016262260107 3649 10140899 SGTC_202 3594-0513 34.79 µM -0.671949685737229 0.246970619169068 no 2527 0.250807863947606 3608 708429 SGTC_1318 1280-3875 124 µM -0.673356934008623 0.246517027712712 no 2528 0.250360119929945 3625 373245 SGTC_2770 toltrazuril 17.5 µM -0.673903279927259 0.246341047058093 no 2529 0.250186403366513 3624 68591 Kills coccidiodes. SGTC_138 0850-0259 40.9225 µM -0.675103146889815 0.245954800580844 no 2530 0.249805117230375 3671 6813004 SGTC_1205 4161-2785 76 µM -0.675652112159887 0.245778192816042 no 2531 0.249630773438035 3607 3498106 SGTC_1909 st060837 51.5 µM -0.677096346410173 0.245313893163101 no 2532 0.249172413438698 3611 678937 SGTC_889 0919-1524 82.7 µM -0.677496346261425 0.245185382633445 no 2533 0.249045543752334 3623 3905452 SGTC_1509 1326-1131 80 µM -0.678217891310604 0.244953658782541 no 2534 0.248816775124769 3590 768313 SGTC_1508 1080-0625 72.9 µM -0.678809745707836 0.244763673028122 no 2535 0.24862920896937 3581 767111 SGTC_1565 sinapyl alcohol 95.1 µM -0.679850170118338 0.244429888307661 no 2536 0.248299667947818 3623 5280507 A phenol propionate derived from cinnamic acid. SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.680111782917986 0.244345997360968 no 2537 0.2482168421196 3681 1377 SGTC_2539 epi(13)torulosol 80 µM -0.683990568645154 0.243104016078907 no 2538 0.246990560673011 3637 6708597 SGTC_1378 2093-0007 380 nM -0.684066756680695 0.243079655018623 no 2539 0.24696650626422 3661 3618014 SGTC_1437 4092-1038 11.6 µM -0.684375139472821 0.242981063368123 no 2540 0.246869155152199 3647 3977136 SGTC_1312 1218-2183 165 µM -0.684563582136905 0.242920827876164 no 2541 0.246809677175509 3664 6744073 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.686993917927902 0.242144698169353 no 2542 0.246043280566699 3632 15053 SGTC_1732 st034308 51.822 µM -0.687448655527996 0.241999626802918 no 2543 0.245900022815562 3582 830119 SGTC_1394 3474-0001 65.7 µM -0.687498575551765 0.241983704081639 no 2544 0.245884299043978 3611 5017666 YIL048W NEO1 SGTC_1895 st058434 18.3 µM -0.688972129476035 0.241513948567923 no 2545 0.245420403286442 3666 5393175 SGTC_3325 9138760 55.175 µM -0.692667439564345 0.240338098873019 no 2546 0.244259138604893 3660 43844959 SGTC_1809 st050081 57.6 µM -0.693413331039441 0.240101134664136 no 2547 0.244025099297679 3714 5036894 SGTC_935 2996-0153 430 µM -0.69441536827627 0.239782995422273 no 2548 0.243710879313795 3663 23738523 SGTC_612 0302-0167 22.4 µM -0.694971622356768 0.239606488282749 no 2549 0.243536542855039 3697 235821 SGTC_1987 st072290 61.9 µM -0.69503900149136 0.239585112764966 no 2550 0.24351543003018 3672 54697379 SGTC_3111 9122088 49.47 µM -0.69563194636199 0.239397050410996 no 2551 0.243329677152377 3579 16876704 SGTC_1180 1193-0155 285 µM -0.695819235096745 0.239337665424457 no 2552 0.243271020799984 3658 2921347 SGTC_648 0375-0473 33.3 µM -0.696274461741187 0.239193356991849 no 2553 0.243128481711203 3678 1713139 SGTC_3249 9135183 49.47 µM -0.698460962175685 0.238500891823122 no 2554 0.242444481606156 3691 4902779 SGTC_1837 st055472 66.5 µM -0.699217084079955 0.238261683479157 no 2555 0.242208187775276 3734 676091 SGTC_857 0438-0306 1.35 µM -0.700402787238791 0.23788683667589 no 2556 0.241837898055945 3710 4686136 SGTC_1606 st000094 49.2 µM -0.700515974414158 0.237851070730922 no 2557 0.241802566282314 3695 1242210 SGTC_271 rotenone 740 µM -0.700572259228805 0.237833286425295 no 2558 0.241784997822934 3701 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1270 0831-1170 17.3 µM -0.701154750839552 0.237649279458519 no 2559 0.241603222503391 3653 6764716 SGTC_2887 9044784 58.44 µM -0.701189529042731 0.237638295623125 no 2560 0.241592371786757 3690 6465546 SGTC_872 0588-0139 234 µM -0.701653248920778 0.237491867789053 no 2561 0.241447717576343 3688 2047100 SGTC_1764 st044502 93.5 µM -0.702566045333308 0.237203780765384 no 2562 0.241163114544312 3689 8407 SGTC_293 4049-0273 38.5 µM -0.702727087253023 0.237152974369276 no 2563 0.241112921820627 3600 1380311 SGTC_3151 9099821 49.47 µM -0.708208374895957 0.23542727692741 no 2564 0.239407933052896 3647 17174189 SGTC_621 3584-0052 32.1 µM -0.708469572776359 0.235345216222641 no 2565 0.23932685050894 3696 2273927 SGTC_504 lovastatin 124 µM -0.709814537703816 0.234922917800899 no 2566 0.238909576368249 3673 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2054 5233173 129 µM -0.710387138203322 0.234743257166012 no 2567 0.238732048406941 3708 6889 SGTC_549 1661-1316 519 µM -0.711050472912311 0.234535222533577 no 2568 0.238526479652322 3715 2857282 SGTC_2193 5925765 200 µM -0.712286437033932 0.234147872393083 no 2569 0.238143710508325 3682 877370 SGTC_1888 azatryptophan 97.5 µM -0.714880329589549 0.233336101604731 no 2570 0.237341496311611 3671 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2569 tetrandrine 100 µM -0.716288428364384 0.232896085319851 no 2571 0.236906635236898 3708 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1746 st038117 42 µM -0.71710017882513 0.23264263131451 no 2572 0.236656142714438 3753 2898218 SGTC_179 1273-0063 6.77 µM -0.717262367803724 0.232592009202128 no 2573 0.236606111396568 3699 3108139 SGTC_1402 3909-7673 35.9 µM -0.717539760499612 0.232505444121963 no 2574 0.236520556049663 3705 5328014 SGTC_2228 7354201 200 µM -0.718703132391208 0.232142589450307 no 2575 0.236161926448518 3726 753451 SGTC_1229 0139-0193 12.2 µM -0.719413435850101 0.23192120148375 no 2576 0.235943110417827 3733 3090752 SGTC_1000 4048-0884 8.67 µM -0.721671902070832 0.231218062743785 no 2577 0.235248110523034 3690 13040088 SGTC_1143 3454-2408 5.08 µM -0.722049405664093 0.231100648925938 no 2578 0.23513205135279 3659 X1143 SGTC_2141 5621638 7.665 µM -0.722845568047936 0.2308531300358 no 2579 0.234887384027129 3721 2856238 SGTC_2752 diclazuril 33.15 µM -0.722990462346689 0.230808099781387 no 2580 0.234842871941454 3756 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1999 st074831 12.5 µM -0.723677171368872 0.230594751063381 no 2581 0.234631975712599 3698 17112523 SGTC_2977 9011197 71.43 µM -0.724141589967655 0.230450526656373 no 2582 0.234489406816411 3716 2704722 SGTC_1245 0418-0076 17.2 µM -0.725198883526282 0.2301223740835 no 2583 0.234165013848724 3727 6790114 SGTC_2606 farnesol 9.78 µM -0.725271759589714 0.230099765148873 no 2584 0.234142663575004 3739 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1952 st077036 64.1 µM -0.725309763082394 0.230087975508908 no 2585 0.2341310087974 3719 2937007 SGTC_2955 9076254 12.21 µM -0.726061394008205 0.229854870136318 no 2586 0.233900567284635 3657 16459619 SGTC_2143 5623677 140.463 µM -0.726190181363235 0.229814942230807 no 2587 0.233861095157909 3669 5375313 SGTC_2249 haloperidol 116.36 µM -0.727138978468618 0.229520906666603 no 2588 0.233570411461914 3709 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_144 4161-2749 112.381 µM -0.728001668641961 0.22925373901159 no 2589 0.233306282419757 3646 797501 YMR168C CEP3 SGTC_2513 baicalein 25.65 µM -0.72883193905144 0.228996776226102 no 2590 0.233052235905936 3712 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_812 4251-0442 148 µM -0.729638739492992 0.228747232116566 no 2591 0.232805517971697 3703 5723007 SGTC_3303 9125618 40.5795 µM -0.730364951743832 0.228522744625971 no 2592 0.232583567903653 3752 22695467 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.730560095864405 0.228462442573701 no 2593 0.232523946651983 3730 521171 SGTC_2822 7994718 71.43 µM -0.731000660190645 0.228326335390275 no 2594 0.232389374843675 3688 1018011 SGTC_749 1000-0129 128 µM -0.73160218029057 0.228140576416872 no 2595 0.23220570854308 3760 708470 SGTC_1652 st011932 78 µM -0.731646001342091 0.228127047100837 no 2596 0.232192331515288 3673 1551076 SGTC_2142 5622915 118.518 µM -0.732094221380882 0.227988689508968 no 2597 0.232055530311769 3736 5322196 SGTC_2941 9056145 11.23 µM -0.733615111285907 0.227519569696389 no 2598 0.231591674224416 3612 2119517 SGTC_1131 3454-3128 32.3 µM -0.733814507059941 0.227458106229259 no 2599 0.231530898865895 3814 710982 SGTC_948 3448-0295 75.3 µM -0.735071358086604 0.227070899003725 no 2600 0.231148018372632 3742 678569 SGTC_1352 1496-0991 99 µM -0.735108383437493 0.227059497972888 no 2601 0.231136744524207 3726 3000039 SGTC_2256 7954252 200 µM -0.735406121416857 0.226967828742152 no 2602 0.231046097447612 3693 2972920 SGTC_13 0199-0087 65 µM -0.735549388241077 0.226923726391487 no 2603 0.23100248657471 3762 4589825 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.739094147514623 0.225834070580951 no 2604 0.229924915196649 3758 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3096 9117468 49.47 µM -0.740652044692671 0.225356112037704 no 2605 0.229452221525023 3691 41316311 SGTC_1740 st038286 13.222 µM -0.742211337963088 0.224878299243531 no 2606 0.228979650094823 3758 716786 SGTC_2069 5228469 200 µM -0.7438680333796 0.224371269439573 no 2607 0.228478158116133 3711 2835210 SGTC_2746 daunorubicin 9.88 µM -0.743882652983112 0.224366798016314 no 2608 0.22847373541981 3628 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2988 9073640 71.4286 µM -0.743885074627365 0.224366057358399 no 2609 0.228473002832962 3755 9102229 SGTC_452 diindolylmethane 8 µM -0.744135876682033 0.224289357270249 no 2610 0.228397138270862 3716 3071 Inhibits expression of several cancer promoting factors. SGTC_2385 9074692 200 µM -0.744739874629544 0.224104704195384 no 2611 0.228214494365573 3755 17046906 SGTC_1435 4092-0789 56.7 µM -0.745205890584239 0.223962293736763 no 2612 0.22807363118962 3751 2248285 SGTC_180 1486-1293 102.781 µM -0.745522678078105 0.223865515573809 no 2613 0.227977903395163 3725 4140536 SGTC_2313 7726885 200 µM -0.745789533065173 0.223784010172351 no 2614 0.227897281896814 3749 726423 SGTC_2831 7999036 19.48 µM -0.746007774553263 0.223717365311141 no 2615 0.227831359301317 3781 2988270 SGTC_2507 purpurin 79.67 µM -0.746551797929768 0.223551284882664 no 2616 0.22766707689788 3760 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2301 7769476 200 µM -0.746590408896972 0.2235395003233 no 2617 0.227655419819041 3788 977820 SGTC_418 lividomycin a 100 µM -0.746638257613894 0.223524896775243 no 2618 0.227640974227442 3744 72394 An antibiotic. SGTC_174 3553-0389 74.3 µM -0.747267567020437 0.223332880479679 no 2619 0.22745103290961 3726 738071 SGTC_365 0121-0052 13.6 µM -0.747500000882127 0.223261983483898 no 2620 0.227380901137984 3776 3101739 SGTC_601 0986-0029 62.9 µM -0.748698952939272 0.222896482551983 no 2621 0.227019337452822 3731 24747981 SGTC_1703 st026983 48.3 µM -0.748982401680632 0.222810122956022 no 2622 0.226933906234711 3756 1104023 SGTC_1963 st076565 50.3 µM -0.750867023867725 0.222236411712793 no 2623 0.226366343940333 3763 4914280 SGTC_2183 6420625 130.508 µM -0.75090935790438 0.222223534195075 no 2624 0.226353604071674 3761 2897619 SGTC_2355 9061122 103.12 µM -0.751236438149652 0.222124054573257 no 2625 0.226255187248668 3777 5302957 SGTC_1518 st038567 90.8 µM -0.752016917454421 0.221886778889732 no 2626 0.226020442593741 3746 77966 SGTC_1303 1160-0052 261 µM -0.75209958022261 0.221861656831996 no 2627 0.225995588189765 3749 3562476 SGTC_2327 6189656 200 µM -0.752939847299193 0.221606383305282 no 2628 0.225743030856885 3817 5349088 SGTC_1942 st076330 65.2 µM -0.753270503293474 0.221505975903552 no 2629 0.225643690062623 3787 24208414 SGTC_3169 9102970 49.47 µM -0.753568225745817 0.221415591394958 no 2630 0.225554264839492 3821 17027839 SGTC_75 0159-0059 199.013 µM -0.753687217533341 0.221379472997202 no 2631 0.225518529554584 3807 5377270 SGTC_2052 5265182 7.135 µM -0.753818304504671 0.221339687165298 no 2632 0.225479165587363 3761 1239884 SGTC_2354 9060492 162 µM -0.754260251002753 0.221205583382508 no 2633 0.225346482606979 3823 6471895 SGTC_2502 avocadyne acetate 18.59 µM -0.755715829305561 0.220764233009223 no 2634 0.224909795682642 3734 3952079 SGTC_775 4577-0580 57.3 µM -0.757642406445534 0.220180845818045 no 2635 0.224332543077208 3833 2006902 SGTC_2048 5246248 200 µM -0.758422924979675 0.219944748734627 no 2636 0.224098919031506 3738 677046 SGTC_2011 4012611 177 µM -0.75905566796472 0.219753458569079 no 2637 0.223909628485971 3799 2049887 SGTC_322 k048-0136 19.3 µM -0.760076939663227 0.219444910404833 no 2638 0.223604297967671 3807 6823282 SGTC_1465 k213-0056 144 µM -0.760176950283086 0.219414708429821 no 2639 0.223574410436991 3667 24048857 YMR208W ERG12 SGTC_2393 9031399 185.94 µM -0.76055474958797 0.219300639248251 no 2640 0.223461528048534 3795 1526623 YDL150W RPC53 SGTC_602 3130-1533 38.1 µM -0.763040647436077 0.218550920989262 no 2641 0.222719577442423 3797 720941 SGTC_2949 9072542 2.23 µM -0.76366872246984 0.218361734557261 no 2642 0.222532342180316 3844 16457352 SGTC_1891 st059073 26.2 µM -0.764160193082841 0.21821376141491 no 2643 0.222385892636171 3781 688754 SGTC_878 0828-0289 13.7 µM -0.765463491265824 0.21782164119581 no 2644 0.221997799149812 3770 745350 YLR208W SEC13 SGTC_2899 9053889 58.44 µM -0.765889412027659 0.217693583596094 no 2645 0.221871053214521 3709 6470052 SGTC_895 0964-0006 13.7 µM -0.769125906945504 0.2167219171638 no 2646 0.220909284989333 3750 6738897 SGTC_730 1436-0052 41.2 µM -0.769603656665502 0.216578699013926 no 2647 0.220767517633308 3805 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1002 4049-0206 172 µM -0.770627514571735 0.21627195492396 no 2648 0.220463873781673 3809 4662749 SGTC_1129 3453-1384 223 µM -0.770901508876809 0.216189909911481 no 2649 0.220382656356406 3931 1084452 SGTC_2982 9019404 25.97 µM -0.771407044933188 0.216038579216767 no 2650 0.220232850319933 3721 22333232 SGTC_3116 9124943 49.47 µM -0.772286409564468 0.215775490317474 no 2651 0.219972406440128 3744 41905195 YPL160W CDC60 SGTC_3261 9137475 49.47 µM -0.773728243302719 0.21534452364524 no 2652 0.219545757175937 3694 17027690 SGTC_1759 st043059 70 µM -0.778189340897398 0.214014261081782 no 2653 0.218228699853853 3807 669426 SGTC_92 0063-0024 660.874 µM -0.778594646410635 0.213893639799988 no 2654 0.218109266852907 3874 3594437 SGTC_923 1900-2434 73.3 µM -0.780990460481879 0.213181440548541 no 2655 0.217404052702286 3784 5910570 SGTC_1863 st057641 20.1 µM -0.781619443337312 0.212994693436393 no 2656 0.217219128366457 3821 3921635 SGTC_1114 scopoletin 1.73284 µM -0.783075258417828 0.212562823393053 no 2657 0.216791459611305 3803 5280460 A coumarin with genotoxic properties. SGTC_1843 st055809 45.5 µM -0.784464181974341 0.212151273975784 no 2658 0.216383895497427 3848 16413835 SGTC_1025 k007-0731 70 µM -0.78496836081688 0.212001996979705 no 2659 0.216236059623144 3792 6256118 SGTC_1752 st044819 83.042 µM -0.785772486073417 0.211764039177236 no 2660 0.216000394187364 3817 441209 YML126C ERG13 SGTC_1084 voriconazole 435 nM -0.786430070676692 0.211569562095873 no 2661 0.215807786140258 3809 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_446 go6976 132 µM -0.787826630201223 0.21115688419783 no 2662 0.215399060990605 3789 3501 A protein kinase C inhibitor. SGTC_781 4335-2806 94.4 µM -0.787875234033331 0.211142530454012 no 2663 0.21538484440478 3938 845254 SGTC_1142 3253-1408 9.78 µM -0.788033773645066 0.211095714314476 no 2664 0.21533847546681 3762 256655 SGTC_3142 9086498 49.47 µM -0.788047947583502 0.211091529101092 no 2665 0.21533433022044 3778 25236367 SGTC_245 methotrexate 289.6 µM -0.790003868827075 0.210514460482716 no 2666 0.214762754453235 3814 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2479 5617353 43.85 µM -0.790474999830617 0.210375598022918 no 2667 0.214625208443687 3833 2731746 SGTC_1919 st067113 52.3 µM -0.791635465066207 0.210033788726716 no 2668 0.214286630772075 3863 1268243 SGTC_2665 lovastatin 100 µM -0.793133623110486 0.209592996582803 no 2669 0.213849987539086 3836 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2240 6690706 185.951 µM -0.795033065633854 0.209034920370497 no 2670 0.213297134095531 3728 805876 SGTC_2658 polymyxin b sulfate 77.05 µM -0.795418292193333 0.208921843585915 no 2671 0.213185111437833 3839 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1631 benzylvanillin 81.9 µM -0.795775064544033 0.208817151202728 no 2672 0.213081393784769 3890 75506 SGTC_1977 st070720 65.3 µM -0.799192252222673 0.207815968052728 no 2673 0.212089471886531 3876 682188 SGTC_1412 3909-8563 178 µM -0.799655317644637 0.207680515499831 no 2674 0.211955263916248 3908 23767530 SGTC_2651 TUB2.036 5 µM -0.800282115567816 0.207497252205047 no 2675 0.211773681309415 3882 15992207 YFL037W TUB2 SGTC_1473 k844-0725 134 µM -0.803682682950881 0.206504660852857 no 2676 0.210790128841505 3893 54682906 SGTC_27 0485-0001 32.618 µM -0.803800313968868 0.206470375952344 no 2677 0.210756154212936 3770 2054479 SGTC_3184 9108758 49.47 µM -0.805851615623106 0.205873043047352 no 2678 0.21016420620171 3838 902885 SGTC_1109 tnp00067 928.257 nM -0.808396883838851 0.205133295601746 no 2679 0.209431072632329 3835 676295 SGTC_2870 9038528 12.99 µM -0.810653879827844 0.204478653805184 no 2680 0.208782232912487 3882 6463316 SGTC_592 k241-0073 46.5 µM -0.812787356384485 0.203860983460764 no 2681 0.208169992929004 3838 4230158 SGTC_2165 5727197 32.143 µM -0.813048471199979 0.203785463639957 no 2682 0.208095134110826 3956 1361712 SGTC_2536 dehydroabietamide 32.04 µM -0.813869842552186 0.20354801476899 no 2683 0.207859759371037 3897 3983547 SGTC_633 0437-0093 97.7 µM -0.814080620747872 0.203487107869446 no 2684 0.207799383472009 3810 2831118 SGTC_564 3555-0129 330 µM -0.814431746100549 0.203385670110412 no 2685 0.20769882914097 3730 563260 SGTC_3123 9126162 49.47 µM -0.814623683492923 0.203330233441253 no 2686 0.207643874781953 3936 25239884 SGTC_822 1487-0950 154 µM -0.815317347990141 0.203129959711537 no 2687 0.207445340577579 3840 1958375 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.817654002867687 0.202456191395505 no 2688 0.206777391053488 3886 5282362 SGTC_1162 k048-0130 20.1 µM -0.820908190969312 0.201520084307996 no 2689 0.205849282542192 3832 6797406 SGTC_2231 micatex 6.853 µM -0.822607731415398 0.201032223312995 no 2690 0.205365550306304 3900 20737 An antifungal of unknown mechanism. SGTC_607 4491-0986 66.8 µM -0.823075247606588 0.200898144963061 no 2691 0.205232601865875 3874 698981 YDR232W HEM1 SGTC_1026 k007-1105 30.6 µM -0.823793508519799 0.200692260437004 no 2692 0.205028448344965 3865 7066794 SGTC_3052 9092717 49.47 µM -0.824644888010551 0.200448382508578 no 2693 0.204786614529339 3854 25237534 SGTC_1830 st055982 50.3 µM -0.825558114335901 0.200186986499033 no 2694 0.204527401830968 3771 455313 An antimicrobial agent. SGTC_1117 retinoic acid 1.10837 µM -0.825696467379402 0.200147403093595 no 2695 0.204488148356594 3846 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_972 1319-0219 195 µM -0.827340715714987 0.199677336780895 no 2696 0.20402198619496 3850 23903702 SGTC_1550 gossypolone 36.6 µM -0.829963496736179 0.198928898717293 no 2697 0.203279711255652 3879 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1054 3429-0080 167 µM -0.83016206258675 0.198872304800023 no 2698 0.203223580710388 3882 1162877 SGTC_1971 st069429 63.5 µM -0.830596165793009 0.198748613398097 no 2699 0.203100900747592 3881 1246522 YGL099W LSG1 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.831489664299037 0.198494170011712 no 2700 0.202848532339767 3932 688664 SGTC_3270 9137563 49.47 µM -0.833182551677349 0.198012622239707 no 2701 0.20237089077355 3864 17015724 SGTC_340 k038-0059 454 µM -0.83457077531575 0.197618264124355 no 2702 0.201979711267956 3869 23733424 SGTC_296 1222-0039 74.9 µM -0.835194312080698 0.197441288212151 no 2703 0.201804155850891 3866 5984176 SGTC_899 1083-0020 478 µM -0.836442402499096 0.197087335794992 no 2704 0.201453033310316 3953 767123 SGTC_444 curcumin 90.4 µM -0.839421756780968 0.196243959114585 no 2705 0.200616339535036 3853 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2330 7979373 200 µM -0.84277003649184 0.195298765235154 no 2706 0.199678534430023 3848 1863007 SGTC_3276 9139060 49.47 µM -0.843247989886676 0.195164068585108 no 2707 0.199544882004161 3964 4870619 SGTC_19 0279-0214 38.434 µM -0.84364749761581 0.195051522796016 no 2708 0.199433207041968 3947 3566274 YBR002C RER2 SGTC_1102 cgs 12066b 26.1 µM -0.844718715705776 0.19474994348157 no 2709 0.199133953680881 3899 6438352 A 5-HT1B full agonist. SGTC_624 k048-0052 28 µM -0.844811157096809 0.194723931820147 no 2710 0.199108142122237 3890 6835531 SGTC_3003 9075612 71.4286 µM -0.845136429242376 0.194632421778406 no 2711 0.199017335400313 3922 6501993 SGTC_71 0417-1750 47.813 µM -0.847115845701958 0.194076109403459 no 2712 0.198465276875963 3855 6811472 SGTC_3090 9117696 49.47 µM -0.848454814199624 0.193700343932889 no 2713 0.198092363453405 3849 7923821 SGTC_2068 5226020 147 µM -0.848488955680365 0.19369076833868 no 2714 0.198082860313255 3941 1810509 SGTC_2811 7967822 32.47 µM -0.849568310359584 0.19338819266437 no 2715 0.19778256833395 3977 2232244 SGTC_3247 9135149 49.47 µM -0.850433527131911 0.193145854674889 no 2716 0.197542051337926 3876 8934436 YOR116C RPO31 SGTC_2476 5806916 10.51 µM -0.851157176844917 0.192943310543777 no 2717 0.197341023670237 3800 2870194 SGTC_1235 benzylparaben 21.5 µM -0.851243475886473 0.192919164749188 no 2718 0.197317058322062 3919 7180 SGTC_3294 9122953 26.2835 µM -0.852435917126785 0.192585718010647 no 2719 0.196986096190246 3904 16459826 SGTC_821 1114-0266 29.2 µM -0.853059864385722 0.192411381812363 no 2720 0.19681305358736 3941 3123235 SGTC_547 1120-0019 610 nM -0.854550616833415 0.191995243701005 no 2721 0.196399988152976 3832 3676939 SGTC_1814 st052110 31.539 µM -0.855268603706301 0.191795016959512 no 2722 0.196201232235582 3830 674163 SGTC_1350 1495-0454 146 µM -0.855778353117335 0.191652939540727 no 2723 0.196060195483865 3943 1069057 SGTC_803 4488-1585 147 µM -0.857488849622002 0.191176660988465 no 2724 0.195587387273284 3932 747204 SGTC_3119 9125183 49.47 µM -0.85787446739495 0.191069388116535 no 2725 0.195480892148777 3735 22695334 SGTC_2827 7993847 71.43 µM -0.858081281700099 0.191011870801121 no 2726 0.195423791255318 3980 2985692 SGTC_3318 9139014 38.6185 µM -0.860655370125297 0.190296877623236 no 2727 0.194713940193742 3912 16643984 SGTC_1431 4049-0260 9.09 µM -0.861857682463987 0.189963480658637 no 2728 0.194382919140042 3891 3854841 SGTC_1468 k284-1086 134 µM -0.862500024388474 0.189785508762475 no 2729 0.194206209836545 3914 15996457 SGTC_1241 0364-0022 50.8 µM -0.863839155415964 0.189414809285926 no 2730 0.193838127456138 3943 4563895 SGTC_2489 cantharidin 73.42 µM -0.865037259949932 0.189083526877479 no 2731 0.193509169228129 3877 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1033 k072-0102 21.3 µM -0.865425563047627 0.188976235578038 no 2732 0.193402627685388 3898 5965931 SGTC_1731 st035964 63 µM -0.865664574473382 0.188910213431003 no 2733 0.193337066181647 3905 6739575 SGTC_2723 salbutamol 83.58 µM -0.866957321138994 0.188553364268219 no 2734 0.192982697249286 3937 9884233 β2-adrenoceptor agonist SGTC_542 3381-0244 89.3 µM -0.867681770918594 0.18835356935072 no 2735 0.192784283933997 3966 1112843 SGTC_1836 st055642 81 µM -0.870310784071503 0.187629615270634 no 2736 0.192065293567714 3942 8571 SGTC_1440 4100-1550 40 µM -0.870946618465284 0.18745478340179 no 2737 0.191891650399303 3927 742806 SGTC_1505 k297-0037 20.6 µM -0.871573166867013 0.187282603377056 no 2738 0.19172063722585 3941 4089396 SGTC_255 tunicamycin 200.472 nM -0.87264854583236 0.186987309502241 no 2739 0.191427335697537 3880 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1409 3909-8004 61.9 µM -0.872875394246004 0.186925054833573 no 2740 0.191365499633717 3943 2119279 SGTC_2748 diazoxide 86.69 µM -0.873292944019917 0.186810498970517 no 2741 0.191251712752243 3931 3019 A potassium channel activatior. SGTC_1676 st018489 23.4 µM -0.873338417486539 0.186798025831274 no 2742 0.191239323239945 3979 3696235 SGTC_806 3966-4455 5.86 µM -0.874943426410187 0.186358110312444 no 2743 0.190802344361338 3923 714982 SGTC_2911 7942208 15.64 µM -0.875638786076921 0.18616771921186 no 2744 0.190613216477645 3973 1243384 SGTC_1096 rimcazole 32.2 µM -0.877530546669846 0.185650361147332 no 2745 0.190099267344042 3871 18528119 A dopamine reuptake inhibitor. SGTC_1461 k072-0203 53.8 µM -0.881198963899369 0.184649668738987 no 2746 0.189105069993576 3861 5418714 SGTC_2610 ononetin 44.17 µM -0.881975904753414 0.184438161412865 no 2747 0.188894918748621 3946 259632 SGTC_1040 k898-0338 155 µM -0.884869393474736 0.183651790851439 no 2748 0.18811353856298 3935 20969351 SGTC_2788 5282734 71.43 µM -0.885970435627285 0.183353107454984 no 2749 0.187816729316409 4036 743706 SGTC_1326 1431-2094 10.8 µM -0.886241260777579 0.183279686245414 no 2750 0.187743767000327 3936 616278 SGTC_920 mycophenolic acid 780.421 nM -0.88704155991502 0.183062830795436 no 2751 0.187528262768759 3973 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3224 9130643 49.47 µM -0.887427008881224 0.182958443602129 no 2752 0.187424523789586 3967 17644395 SGTC_2583 asiatic acid 100 µM -0.888248618260366 0.182736059555496 no 2753 0.187203515868369 3950 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2419 paclitaxel 166.5 µM -0.888398561777825 0.182695492736162 no 2754 0.187163199371402 3877 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2741 miltefosine 3.04 µM -0.89053836892592 0.182117186423357 no 2755 0.186588437776208 3923 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1297 1068-0111 14.1 µM -0.892189396582281 0.181671761132506 no 2756 0.186145712314453 3912 767057 SGTC_65 0798-0905 34.986 µM -0.892253337681019 0.181654524397233 no 2757 0.186128579522073 4035 3602145 SGTC_2620 irigenin 100 µM -0.893142225710314 0.181415011003125 no 2758 0.185890506350103 4017 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1155 4088-0394 48.2 µM -0.893178941474806 0.181405122090238 no 2759 0.185880676735121 3946 2326248 SGTC_3078 9116413 49.47 µM -0.894165215596996 0.181139608306196 no 2760 0.185616750171325 3870 17177322 SGTC_226 1,3-diallylurea 8.28947 mM -0.89477588863014 0.180975331775549 no 2761 0.18545345092881 3937 74537 YKL182W FAS1 SGTC_1271 0832-2808 169 µM -0.895197667595909 0.180861923971172 no 2762 0.185340715673352 4012 3663794 SGTC_403 arphamenine a 50 µM -0.895843852748156 0.180688264315511 no 2763 0.185168082523227 3935 5487158 An arginine aminopeptidase inhibitor. SGTC_669 0108-0021 26.2 µM -0.899313704535405 0.179757544603499 no 2764 0.184242794841176 3907 17201 SGTC_2640 pentamidine 10.38 µM -0.900417317708391 0.179462154439151 no 2765 0.18394910411357 3967 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2791 5663188 71.43 µM -0.902006748562634 0.179037268139781 no 2766 0.183526641412876 4007 54690634 SGTC_29 0299-0004 12.984 µM -0.902086719635556 0.179015907027408 no 2767 0.183505401495798 3859 16871 A napthoquinone isolated from Swertia calycina. SGTC_190 3970-0790 3.722 µM -0.902318820265841 0.178953919596157 no 2768 0.183443765405763 3879 2832352 SGTC_1115 galangin 695.678 nM -0.902715289318276 0.178848065313741 no 2769 0.183338509883984 3995 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_965 1291-5240 308 µM -0.903579981305037 0.178617335743446 no 2770 0.183109080108312 3984 2834598 SGTC_2364 9055074 200 µM -0.904176370093367 0.178458307975045 no 2771 0.182950943958501 3998 6470630 SGTC_429 1112-0049 25.5 µM -0.904942217482064 0.178254224723869 no 2772 0.182747999848125 3942 2836170 SGTC_3020 9089140 49.47 µM -0.906300976988755 0.177892504201247 no 2773 0.182388284273273 4032 17217859 SGTC_439 amiodarone 34.4 µM -0.907441517639819 0.177589234196074 no 2774 0.182086681324902 3848 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_275 trichlorophene 5.69 µM -0.908415824631107 0.177330424329804 no 2775 0.181829284061343 4017 62616 SGTC_576 1073-0113 22.7 µM -0.909475000179496 0.177049340746462 no 2776 0.181549724134411 4124 5439563 SGTC_113 0099-0221 2.5 µM -0.90992136566469 0.17693096880952 no 2777 0.181431990567582 3914 89219 SGTC_308 4092-1169 104 µM -0.910062567266323 0.176893533885435 no 2778 0.181394757121516 3915 2268590 YDL196W YDL196W SGTC_292 k038-0015 474 µM -0.912845448333132 0.176156766943058 no 2779 0.180661915776022 3979 46368540 SGTC_3180 9109287 49.47 µM -0.913492366807516 0.175985774109221 no 2780 0.180491823172049 4033 18891271 SGTC_1417 3966-0327 90.4 µM -0.914767059550309 0.175649156298929 no 2781 0.18015696558374 4068 651118 SGTC_1871 st057448 67.3 µM -0.91576266037223 0.175386524375493 no 2782 0.179895695944599 4017 691747 SGTC_695 3505-6186 243 µM -0.916312184183548 0.175241670857987 no 2783 0.179751589634629 4011 1819379 SGTC_3186 9110464 49.47 µM -0.916556993747288 0.1751771639195 no 2784 0.179687414494782 4009 17018021 SGTC_2543 pimpinellin 60.67 µM -0.916574051177513 0.175172669874522 no 2785 0.17968294354356 3826 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_223 busulfan 5 mM -0.917494112889048 0.174930373675621 no 2786 0.179441888223027 4001 2478 A DNA alkylator. SGTC_3315 9136395 68.55 µM -0.919665112641335 0.174359489175598 no 2787 0.178873894572845 3969 16876844 SGTC_2496 diffractaic acid 79.83 µM -0.920582750526152 0.174118544081821 no 2788 0.178634155703045 3993 94870 An apoptosis inducer which activates caspases. SGTC_1490 4089-0339 670 nM -0.920821400956049 0.174055916094941 no 2789 0.178571839893703 3925 742542 SGTC_2495 cafestol 54.53 µM -0.92179031688598 0.173801794850308 no 2790 0.178318979617917 4021 16667697 An anti-infammatory. SGTC_699 0375-0592 111 µM -0.92233860682524 0.173658097380942 no 2791 0.178175991110076 4066 762578 SGTC_1790 st045711 43.5 µM -0.922618175814223 0.17358485620894 no 2792 0.178103110154302 3979 585119 SGTC_1720 st037298 9.481 µM -0.923590720822299 0.17333022310408 no 2793 0.177849723422727 4022 597396 SGTC_1969 st069479 40.1 µM -0.924226166818969 0.17316397825594 no 2794 0.17768428729794 4011 3895485 SGTC_1086 cerivastatin 2.18 µM -0.92561460294769 0.17280109024389 no 2795 0.177323150834675 3974 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_94 0334-0113 514.748 µM -0.926939872693628 0.172455164148311 no 2796 0.176978876785328 4020 6795178 SGTC_3308 9128332 17.569 µM -0.927544771475926 0.17229741846682 no 2797 0.176821878725926 4026 17332805 YDL196W YDL196W SGTC_630 4356-0227 183 µM -0.927588245092557 0.172286084951306 no 2798 0.176810598786309 3976 779312 SGTC_3347 9188721 44.724 µM -0.927834924519107 0.172221784951503 no 2799 0.176746602394768 4032 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1768 st044301 37.178 µM -0.930079740146505 0.171637350278393 no 2800 0.176164899837969 4008 3931349 SGTC_2781 5567276 71.43 µM -0.930100733482768 0.171631890679037 no 2801 0.176159465527689 4062 2853274 SGTC_2442 5158906 48.48 µM -0.930784921674279 0.171454019074024 no 2802 0.175982415461917 4036 1893835 SGTC_2916 7875993 68.79 µM -0.931157690922724 0.171357158106629 no 2803 0.175885999933599 3879 1299250 SGTC_1730 st033808 45.1 µM -0.931752826852884 0.171202589536584 no 2804 0.175732139356521 3963 1045166 SGTC_994 3910-0338 138 µM -0.932215052739764 0.171082601863963 no 2805 0.175612698880599 4101 3479481 SGTC_354 2783-3500 4.88 µM -0.933416473909497 0.170770980614411 no 2806 0.175302488945591 4025 6740761 SGTC_1388 3346-4487 254 µM -0.934150062098072 0.170580883309493 no 2807 0.175113245607834 4071 3345614 SGTC_625 k213-0058 121 µM -0.934774666562131 0.170419134172126 no 2808 0.174952218922051 4077 3655420 SGTC_3148 9097893 49.47 µM -0.934841912827448 0.170401725769744 no 2809 0.174934888045539 4010 17174100 SGTC_3262 9137218 49.47 µM -0.935371229847652 0.17026473839383 no 2810 0.174798509171656 3838 17650664 SGTC_622 1348-1566 26.3 µM -0.936277350729341 0.170030397900143 no 2811 0.174565203233393 4051 7340407 SGTC_3219 9131112 49.47 µM -0.936695241000285 0.169922393032442 no 2812 0.174457672460821 3950 17612988 YMR079W SEC14 SGTC_249 wiskostatin 11.211 µM -0.937415310097038 0.169736392446042 no 2813 0.174272484309102 3973 2775510 A n-wasp and actin depolymerizer. SGTC_2937 9044753 11.33 µM -0.937613640963673 0.16968518467158 no 2814 0.174221499310197 3971 6465530 YGL099W LSG1 SGTC_3220 9131269 49.47 µM -0.938784471807595 0.169383085503043 no 2815 0.173920706519697 4032 17722206 SGTC_2851 9015922 71.43 µM -0.939488087390218 0.169201703929983 no 2816 0.173740102816066 4044 2996893 SGTC_1480 1070-0044 41.2 µM -0.941292827613543 0.168737039272325 no 2817 0.173277408651269 4024 3124987 SGTC_1737 st035557 69.7 µM -0.944637814511638 0.167877979597994 no 2818 0.172421907300324 3905 5716916 SGTC_2014 4013930 200 µM -0.946092702495883 0.167505215380683 no 2819 0.172050652763183 3955 64556 SGTC_517 1365-0151 113 µM -0.947098811134015 0.167247747318692 no 2820 0.171794215246818 4092 768657 SGTC_3157 9099274 49.47 µM -0.949300169565129 0.166685299238316 no 2821 0.171233983670634 4038 17217662 SGTC_3350 9150499 3.57 µM -0.949857226800846 0.166543164602582 no 2822 0.17109240159266 4001 4910996 YPR165W RHO1 SGTC_2116 5511452 16.8835 µM -0.951100502765321 0.166226221675073 no 2823 0.170776679773707 4071 870744 SGTC_882 0843-0131 351 µM -0.952231366199357 0.165938274152492 no 2824 0.170489828418011 4005 5425421 SGTC_1175 0741-0056 27.6 µM -0.954336633604992 0.165403077012451 no 2825 0.169956635114423 4132 765927 SGTC_3084 9116877 49.47 µM -0.954695804417227 0.165311880920771 no 2826 0.169865776107041 3948 27241325 SGTC_7 0192-1582 4.227 µM -0.957799852582747 0.1645250964119 no 2827 0.169081846776946 4070 252616 SGTC_637 1181-0519 7.26 µM -0.958000091730788 0.164474425167794 no 2828 0.16903135615168 4039 6252091 YGR060W ERG25 SGTC_817 1391-0715 46 µM -0.958517165709869 0.164343624509444 no 2829 0.168901019905093 4046 1353946 SGTC_220 paclitaxel 373.376 µM -0.962062454644592 0.163448614109665 no 2830 0.168009116258914 4008 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1944 st076371 56.9 µM -0.963171821224333 0.163169205344233 no 2831 0.167730651902103 4025 24208455 SGTC_96 0929-0093 37.281 µM -0.966177835001682 0.162413661714204 no 2832 0.166977600994229 4043 6991579 SGTC_420 mitomycin C 81.9 mM -0.967013973354688 0.162203908729351 no 2833 0.166768524175677 4037 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_742 0kpi-0133 140 µM -0.96949232130667 0.16158322905399 no 2834 0.166149804786306 4108 2728852 SGTC_603 3794-0023 45.9 µM -0.971840445258696 0.160996593117025 no 2835 0.165564965661125 4097 3802260 SGTC_842 0271-0008 11.1 µM -0.972839950287955 0.160747307321571 no 2836 0.165316426873563 4113 1221709 SGTC_1178 0988-0033 191 µM -0.974138928556529 0.1604237069732 no 2837 0.164993781467556 4111 5392207 SGTC_109 0132-0036 33.701 µM -0.974685187960497 0.160287750526014 no 2838 0.164858221243671 3854 67274 A color developer. SGTC_2692 st077426 47.7 µM -0.977839955190187 0.159504046126726 no 2839 0.164076743135387 4082 25238571 SGTC_1042 0350-0096 82 µM -0.979782748465863 0.159022669247727 no 2840 0.163596684776137 4041 3122515 SGTC_98 0074-0023 107.663 µM -0.979816397310467 0.159014340277762 no 2841 0.163588378290721 4088 3563821 SGTC_64 000l-0018 272.079 µM -0.98182161419087 0.15851851265965 no 2842 0.163093868968312 3997 6811119 SGTC_2680 butyl paraben 22.24 µM -0.982425874373372 0.158369296988329 no 2843 0.162945042228003 4135 7184 An antifungal and steroid mimetic. SGTC_2306 7482397 179.52 µM -0.984034464808069 0.15797252187434 no 2844 0.162549283699756 4085 891448 SGTC_1434 4073-0095 163 µM -0.984333473398078 0.157898840376056 no 2845 0.162475788159597 4006 24133745 SGTC_744 1594-0068 283 µM -0.985603850432216 0.157586046564909 no 2846 0.162163773914235 4047 668392 SGTC_2888 9058547 12.99 µM -0.986741269847502 0.157306335427935 no 2847 0.161884746339604 3975 16476514 SGTC_2175 5807670 165.306 µM -0.992400743874566 0.155919427972556 no 2848 0.16050103812121 4062 241186 SGTC_859 0439-0102 54.6 µM -0.99323694606368 0.155715194297553 no 2849 0.160297248687359 4093 610143 SGTC_1630 st005209 31.3 µM -0.994275245399969 0.155461846134439 no 2850 0.160044441958962 4033 3367314 SGTC_50 0929-0078 56.389 µM -0.997652387559972 0.154639695132168 no 2851 0.15922397419856 3947 1377751 SGTC_2212 7123476 200 µM -0.997851156477352 0.15459139537504 no 2852 0.159175769808437 4052 1085715 SGTC_163 TUB2.036 7.546 µM -0.999952736012523 0.154081333103284 no 2853 0.158666690703018 4072 15992207 YJR013W GPI14 SGTC_2074 5212007 75.395 µM -1.00026666953584 0.154005235790629 no 2854 0.158590736314252 3955 758611 SGTC_1497 4476-2978 41.3 µM -1.00047911632786 0.153953752915857 no 2855 0.158539349578963 4130 1528379 SGTC_731 3966-0296 387 µM -1.00263663413393 0.153431560247144 no 2856 0.158018106729631 4085 660956 SGTC_382 3229-0966 23.2 µM -1.00496495945003 0.15286934408901 no 2857 0.157456861472556 4125 5722370 SGTC_2807 7945238 51.95 µM -1.00766238740774 0.152219711622833 no 2858 0.15680828374392 4134 17148797 SGTC_2131 toluylene red 5.2905 µM -1.00863954395797 0.151984831984027 no 2859 0.156573767663794 4093 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2763 lisinopril 49.32 µM -1.00942091517886 0.15179718667706 no 2860 0.156386405993086 3972 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3259 9138485 49.47 µM -1.01030240726129 0.151585682341991 no 2861 0.156175214092856 4090 17646153 SGTC_2208 7283366 200 µM -1.01520668132697 0.150412533924237 no 2862 0.15500365819541 4084 898663 SGTC_3133 9127736 49.47 µM -1.01567285339222 0.150301336856376 no 2863 0.154892599670788 4116 27243420 SGTC_2572 astragaloside iv 100 µM -1.01584707670309 0.150259793045563 no 2864 0.154851107067151 4159 45006101 An anti-inflammatory agent. SGTC_1135 dihydrocapsaicin 536.708 nM -1.01745567015175 0.149876583050337 no 2865 0.154468355203118 4024 107982 A Capsaicinoid. SGTC_3010 9080089 71.4286 µM -1.01747301216018 0.149872455274485 no 2866 0.154464232222243 4131 17027233 SGTC_3062 9077494 49.47 µM -1.01831403296419 0.149672364996588 no 2867 0.154264370796898 4091 16459633 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.01967966871274 0.14934784153118 no 2868 0.153940203565862 4108 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2873 9040596 71.43 µM -1.02194018666015 0.148811695405192 no 2869 0.153404605357989 4106 6463863 SGTC_1366 1683-0113 21.9 µM -1.02227602536992 0.14873215158493 no 2870 0.153325138505007 4121 708623 SGTC_1600 coumarin 106 71.1 µM -1.02345878346841 0.148452240164113 no 2871 0.153045489023375 4184 100336 A hepatotoxic, DNA x-linker. SGTC_1751 st044839 27.194 µM -1.02619599024439 0.147805804894985 no 2872 0.152399605520989 4136 5291326 SGTC_112 phenothiazine 287.218 µM -1.02790377697006 0.147403439911208 no 2873 0.151997546361611 4061 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_169 k015-0017 16.025 µM -1.0286767942838 0.147221553840723 no 2874 0.151815789029212 4069 1840002 SGTC_808 0711-0032 135 µM -1.02896465899871 0.147153859559122 no 2875 0.151748141146729 4051 4252555 SGTC_791 1348-1292 225 µM -1.02990687215473 0.146932434613872 no 2876 0.151526862223779 4101 5437054 SGTC_1079 idarubicin 2.36 µM -1.03175596612223 0.14649853790566 no 2877 0.151093226073449 4136 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2894 9048625 32.47 µM -1.03371924880595 0.146038788692777 no 2878 0.150633715852846 4120 4092861 SGTC_716 1683-5115 658 µM -1.03498078763444 0.145743881531887 no 2879 0.150338941829995 4063 723597 SGTC_2675 theaflavin digallate 100 µM -1.03723000302165 0.145219081145152 no 2880 0.149814339239864 4064 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2391 6285546 200 µM -1.03873102896016 0.14486956108997 no 2881 0.149464923022828 4111 846083 SGTC_258 haloperidol 50.781 µM -1.03944428432991 0.144703675334886 no 2882 0.149299078720901 4127 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2999 9069765 71.4286 µM -1.03948173077581 0.144694969743554 no 2883 0.149290375165598 4099 2097066 SGTC_990 3985-0011 41.3 µM -1.04190944516016 0.144131324743245 no 2884 0.148726832331525 4128 5399565 YGL099W LSG1 SGTC_216 k038-0035 28.382 µM -1.04347230827483 0.143769257477835 no 2885 0.148364799793629 4070 4444231 YPR107C YTH1 SGTC_1928 4'-methoxychalcone 40.3 µM -1.04434595519231 0.143567128022441 no 2886 0.148162679174935 4179 641818 SGTC_3125 9127534 49.47 µM -1.0461067901588 0.143160319344795 no 2887 0.147755865295569 4035 1639235 SGTC_1452 4194-0072 190 µM -1.05029013303478 0.142196959578599 no 2888 0.146792370131867 4206 1343545 SGTC_838 0109-0203 71.4 µM -1.05064846718832 0.142114645177818 no 2889 0.146710036099934 4146 759422 SGTC_3149 9097855 49.47 µM -1.05132606281661 0.141959080088504 no 2890 0.146554430430853 4143 25236625 YMR079W SEC14 SGTC_2940 9060638 45.86 µM -1.05268951579327 0.141646402656387 no 2891 0.146241657647501 4137 4027022 SGTC_2708 st078559 56 µM -1.05276182829423 0.141629832440392 no 2892 0.146225081863838 4085 17250902 SGTC_786 4544-0069 423 µM -1.05324705467889 0.141518678083463 no 2893 0.14611388881766 4146 748821 YLR208W SEC13 SGTC_1382 3002-2117 298 µM -1.05428226744119 0.141281731949192 no 2894 0.145876852411153 4220 1497314 SGTC_1637 st007924 17.4 µM -1.05432637249726 0.14127164287769 no 2895 0.145866759259969 4071 683336 SGTC_2302 7771753 200 µM -1.05511963835017 0.141090265984315 no 2896 0.145685305732179 4155 2203047 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.05584340842788 0.140924916833576 no 2897 0.145519881278742 4141 5106787 A p450 inhibitor. SGTC_1697 st025554 27.742 µM -1.05644247681926 0.140788155916823 no 2898 0.145383054152275 4141 1269519 SGTC_405 ebelactone b 50 µM -1.0565525213906 0.140763043709896 no 2899 0.145357929401127 4112 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2919 7978188 46.38 µM -1.05886389514577 0.140236289784889 no 2900 0.14483088463388 4167 2980291 SGTC_2073 5212005 126 µM -1.05898453977842 0.14020883211256 no 2901 0.14480341034763 3957 691789 SGTC_1405 3909-7894 12 µM -1.06224583498296 0.139467973051212 no 2902 0.144062048424183 4153 7104060 SGTC_961 1252-1571 372 µM -1.06286938324232 0.139326627164198 no 2903 0.143920594605312 4179 6813498 SGTC_1276 0871-0068 94.2 µM -1.06371663188155 0.139134729117814 no 2904 0.143728543854332 4163 3414906 SGTC_1540 guanosine 70.6 µM -1.063790766627 0.139117946490948 no 2905 0.143711747534203 4029 6802 Guanosine is a purine nucleoside SGTC_1642 st009582 77.7 µM -1.06481281179886 0.138886716295062 no 2906 0.143480323125352 4156 6739311 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.06672272585291 0.138455314111002 no 2907 0.143048530887761 4175 5379071 SGTC_1013 4112-3890 241 µM -1.06822084044307 0.138117566921851 no 2908 0.142710453058684 4106 705171 SGTC_2969 9091408 28.7 µM -1.06947692881738 0.137834817449631 no 2909 0.142427409667015 4116 4286311 SGTC_1498 4478-3555 97.6 µM -1.07169200536128 0.13733715955638 no 2910 0.141929196423585 4142 3437919 SGTC_2886 9058944 51.95 µM -1.07301835400996 0.137039758855437 no 2911 0.14163144061065 4024 4949929 SGTC_416 estradiol valerate 100 µM -1.07499843387371 0.136596594535293 no 2912 0.141187714752632 4200 13791 A steroid. SGTC_2491 paeonol 100 µM -1.07799014934377 0.135928875461094 no 2913 0.140519076099896 4091 11092 Increases levels of cortical cytochrome oxidase. SGTC_3060 1327-0027 12.5 µM -1.07892030229731 0.135721731401759 no 2914 0.14031162872876 4071 16000455 YPR107C YTH1 SGTC_1335 1486-0900 202 µM -1.08258977203471 0.134906654088177 no 2915 0.139495274568463 4170 X1335 SGTC_2348 9022543 33.42 µM -1.08344254736206 0.134717714070707 no 2916 0.139306019515368 4213 3162678 YDL140C RPO21 SGTC_2260 7964312 200 µM -1.08372243327728 0.134655742434985 no 2917 0.13924394298186 4232 231951 SGTC_2374 9071832 200 µM -1.08497908194894 0.134377739587098 no 2918 0.138965460023237 4109 17381698 SGTC_1075 aripiprazole 15.2 µM -1.08505108618567 0.134361822353544 no 2919 0.138949514827738 4230 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1479 0549-0158 134 µM -1.08611453440967 0.13412688758785 no 2920 0.138714161382828 4231 5440202 SGTC_185 k048-0037 25.491 µM -1.086657871041 0.134006963778151 no 2921 0.138594019541801 4229 6827589 SGTC_3327 9140648 26.9345 µM -1.08754277314215 0.133811808299847 no 2922 0.138398503010233 4201 8029710 SGTC_634 1611-4317 11.2 µM -1.08932134132601 0.133420155685501 no 2923 0.138006102413653 4214 2843522 SGTC_1343 1487-0095 224 µM -1.09258405831725 0.13270373526073 no 2924 0.137288232614289 4196 4560101 YGL055W OLE1 SGTC_898 1000-0849 28.3 µM -1.09523995472899 0.132122518854138 no 2925 0.136705762840376 4181 6751807 SGTC_696 1560-0013 611 µM -1.09533183197782 0.132102443894707 no 2926 0.136685643344138 4247 1650269 SGTC_1901 st060216 58.6 µM -1.0959391433874 0.131969800701754 no 2927 0.136552703782781 4144 688792 SGTC_2747 doxorubicin 7.63 µM -1.096087940638 0.131937315833931 no 2928 0.136520145777711 4167 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_663 1486-0733 13.9 µM -1.0963522520782 0.131879625934424 no 2929 0.136462325454695 4198 722445 YPR165W RHO1 SGTC_3320 9137005 35.139 µM -1.09739963424186 0.131651190322622 no 2930 0.136233366623425 4226 4908713 SGTC_759 3486-0358 89.3 µM -1.0982487191887 0.131466204151336 no 2931 0.136047948806591 4184 875103 SGTC_2805 7950783 58.44 µM -1.09854787025039 0.131401072274356 no 2932 0.135982663256325 4215 1178958 YDL195W SEC31 SGTC_28 pentachloropyridine N-oxide 1.606 µM -1.09883449900145 0.131338687686976 no 2933 0.135920130649119 4173 140250 A respiratory chain inhibitor. SGTC_2703 st077852 53.4 µM -1.0992496137478 0.131248374457015 no 2934 0.135829601695712 4231 6281836 SGTC_130 0136-0219 337.655 µM -1.09990938049918 0.131104922497113 no 2935 0.135685803585863 4027 234244 SGTC_1788 fluconazole 20 µM -1.09993215442752 0.131099972735313 no 2936 0.13568084180358 4237 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1365 1672-3266 55.4 µM -1.10154821114348 0.130749063124784 no 2937 0.135329066950225 4210 6415873 SGTC_2322 7413319 38.22 µM -1.10349855701335 0.130326431466385 no 2938 0.134905358924382 4214 1840400 SGTC_1101 ebselen 5.29 µM -1.10487684912282 0.130028331935886 no 2939 0.134606477580267 4234 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3041 9091929 49.47 µM -1.10593372723464 0.129800068341735 no 2940 0.134377602646053 4201 25236887 SGTC_871 0574-0004 149 µM -1.10826815537573 0.129296864369178 no 2941 0.133873011997535 4166 9551173 SGTC_1152 3909-8331 15.9 µM -1.10892908287 0.129154642273125 no 2942 0.13373038823031 4162 16001939 SGTC_1176 0848-0131 83.3 µM -1.10949412667801 0.129033138992414 no 2943 0.133608538381142 4244 6769040 SGTC_3251 9135047 49.47 µM -1.1097459435082 0.128979015508915 no 2944 0.133554259505801 4232 17682963 SGTC_804 1595-0054 20.9 µM -1.11026316084891 0.12886789835771 no 2945 0.133442821371139 4145 761523 Stimulates phospholipase C. SGTC_1454 4239-0054 42.6 µM -1.11608705080382 0.1276212967367 no 2946 0.132192437235923 4312 1340767 SGTC_1223 0764-0573 147 µM -1.11650584645965 0.127531977887007 no 2947 0.132102834514369 4209 1609797 SGTC_1797 st048695 56.8 µM -1.11781431771338 0.127253193125037 no 2948 0.131823152606839 4181 592262 YIL048W NEO1 SGTC_1496 4469-0713 57.4 µM -1.11794055913869 0.127226318388219 no 2949 0.131796190494582 4196 746691 SGTC_287 k060-0039 29.6 µM -1.11862413103281 0.127080865679181 no 2950 0.131650262165292 4251 5861974 SGTC_2134 5324836 1.464 µM -1.12155617326735 0.126458288827176 no 2951 0.131025597449469 4160 699272 SGTC_2450 5739737 12.93 µM -1.12187084610565 0.126391599071434 no 2952 0.130958679023183 4237 2262825 SGTC_2832 7992762 51.95 µM -1.12335869695321 0.126076605318041 no 2953 0.130642592020169 4158 2985177 SGTC_3165 9101544 49.47 µM -1.12522555877946 0.125682145664607 no 2954 0.130246732562609 4228 5002184 SGTC_1371 2421-0008 32.7 µM -1.12581478362744 0.125557824015315 no 2955 0.130121962630428 4199 2827552 SGTC_371 0195-0006 7.36 µM -1.13009993364657 0.124656273490973 no 2956 0.129217058853337 4041 3928593 SGTC_2403 6032726 181.2 µM -1.1377825200016 0.12305128665372 no 2957 0.127605652881737 4278 2881040 SGTC_1796 st049173 110.4 µM -1.1416926586881 0.12223999677297 no 2958 0.126790896709725 4191 94134 SGTC_294 k038-0071 157 µM -1.14181463865738 0.122214748463094 no 2959 0.12676553811754 4233 24152826 SGTC_2767 sibutramine 71.45 µM -1.14204792006002 0.122166472361852 no 2960 0.126717050744924 4266 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_702 1488-0190 94 µM -1.14311267980777 0.121946297133473 no 2961 0.126495905196686 4259 949357 SGTC_2360 9040895 200 µM -1.14601091431515 0.121348401073668 no 2962 0.125895318045706 4256 4914414 SGTC_1246 0422-0085 105 µM -1.14721209610459 0.121101206460892 no 2963 0.125646986758693 4268 264295 SGTC_2265 7929201 200 µM -1.15585994759806 0.119331993694282 no 2964 0.123869223841565 4224 1265108 SGTC_2186 6124449 200 µM -1.1571660008067 0.119066389557725 no 2965 0.123602272763945 4247 3834182 YLR033W RSC58 SGTC_2233 sulbentine 40.3845 µM -1.1578910350513 0.118919124026815 no 2966 0.123454253233577 4258 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1194 1488-0194 225 µM -1.15831320346873 0.118833434451332 no 2967 0.12336812256563 4197 1391452 SGTC_983 1491-0821 12.2 µM -1.16070971355866 0.118347829619936 no 2968 0.122879985144502 4245 46495113 SGTC_3332 9141069 11.198 µM -1.16146438810944 0.118195200760609 no 2969 0.122726548690175 4202 17332883 SGTC_1884 5633444 25 µM -1.16215520953376 0.118055607923474 no 2970 0.122586212369956 4233 5724239 SGTC_2236 dapsone 200 µM -1.16377088570417 0.11772958701824 no 2971 0.122258436907109 4238 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1141 3253-0389 52.6 µM -1.16415212468273 0.117652751315773 no 2972 0.122181183988611 4250 5402031 SGTC_3340 9146634 11.102 µM -1.16563321533413 0.117354586027121 no 2973 0.121881386246272 4266 4907387 SGTC_2526 patulin 37.61 µM -1.16585633017457 0.117309716155114 no 2974 0.121836268861295 4280 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_366 0181-0206 4.31 µM -1.16677349154353 0.117125396567868 no 2975 0.121650927434309 4275 274874 SGTC_2657 nystatin 74.44 µM -1.16780051998644 0.116919240905909 no 2976 0.121443619164727 4284 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2744 captopril 92.04 µM -1.16931525450391 0.116615657463631 no 2977 0.12113831968353 4317 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_51 1013-0126 23.419 µM -1.16993592101119 0.116491424925893 no 2978 0.121013378464705 4287 1627850 SGTC_2036 5160441 105 µM -1.17918005748001 0.114652222179585 no 2979 0.119163242670728 4237 134534 YIL048W NEO1 SGTC_1941 st076221 61.8 µM -1.17924650605813 0.114639076878446 no 2980 0.119150016230522 4147 2828568 SGTC_1381 2324-0066 62.1 µM -1.18015829530673 0.114458808967956 no 2981 0.118968631296634 4299 10885928 SGTC_1003 4049-0218 100 µM -1.1807258666586 0.11434669759582 no 2982 0.118855821160947 4289 295161 SGTC_2331 7980721 200 µM -1.18211445293307 0.11407274228595 no 2983 0.118580145194486 4224 2981221 SGTC_506 n9-isopropylolomoucine 153 µM -1.183024417033 0.113893468513117 no 2984 0.118399735310686 4281 6610355 SGTC_656 4090-1979 187 µM -1.18467567661221 0.113568663585328 no 2985 0.118072851528119 4316 22330961 SGTC_23 0213-0011 39.996 µM -1.18502938140489 0.113499175357806 no 2986 0.11800291512114 4271 627608 SGTC_945 3381-0768 11.3 µM -1.1853164104188 0.113442808425734 no 2987 0.117946183747994 4293 1126236 YIL048W NEO1 SGTC_1106 tegaserod maleate 11.7 µM -1.18753153636608 0.113008472107895 no 2988 0.117509012421494 4290 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2687 chenodiol 100 µM -1.18779654633642 0.112956589215865 no 2989 0.117456787699739 4346 5702181 A cholesterol synthesis inhibitor. SGTC_2009 4012297 12.05 µM -1.19117358266408 0.11229693105684 no 2990 0.116792723997285 4261 45595307 SGTC_1105 epirubicin 18.1 µM -1.19174588221708 0.112185413468305 no 2991 0.116680450720144 4306 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_52 0329-0193 875 nM -1.19546008563023 0.111463591888183 no 2992 0.11595366100976 4351 3739292 SGTC_1236 0330-0013 258 µM -1.19619395028124 0.111321366099972 no 2993 0.115810440572813 4292 4617066 SGTC_1397 3532-0190 20.1 µM -1.19795611461293 0.110980382486231 no 2994 0.115467051106742 4229 5322280 SGTC_546 peri-Naphthalide 147 µM -1.1982295818906 0.110927532950206 no 2995 0.115413826000681 4224 223824 A penicillin ester. SGTC_1623 st003709 20.3 µM -1.19902266351058 0.110774366133808 no 2996 0.115259566642612 4255 16192618 SGTC_373 0844-0104 25.9 µM -1.20034891552635 0.110518567522103 no 2997 0.115001929875884 4297 5375804 SGTC_1875 nocodazole 6 µM -1.20485512838713 0.109652603538954 no 2998 0.114129616799486 4309 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_653 0203-0016 55.2 µM -1.20537011557064 0.109553948915112 no 2999 0.114030226425286 4357 295302 SGTC_732 3970-1727 52.7 µM -1.20641699006246 0.109353598666841 no 3000 0.113828374136402 4366 1275699 SGTC_2592 piperlongumine 83.33 µM -1.21023622272008 0.108624907950069 no 3001 0.113094131193303 4299 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2804 7954240 19.48 µM -1.21122769049155 0.108436313112566 no 3002 0.112904076480446 4315 828705 SGTC_571 k831-0106 44.2 µM -1.21140242437091 0.108403100048588 no 3003 0.11287060534261 4182 4783639 SGTC_1293 1000-1278 195 µM -1.21181096573036 0.108325473895322 no 3004 0.112792374870967 4327 678847 SGTC_1021 4476-0760 85.3 µM -1.21230818561206 0.108231052087346 no 3005 0.112697215829712 4305 746768 SGTC_2636 apigenin dimethyl ether 100 µM -1.21632657132448 0.10747013596517 no 3006 0.111930271685384 4295 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2883 9059145 45.46 µM -1.21771040322553 0.107208990030542 no 3007 0.1116670211523 4289 16476510 SGTC_2279 7948423 32.93 µM -1.22011970286417 0.106755418210123 no 3008 0.111209750245613 4287 1247112 SGTC_2026 5148700 152 µM -1.22121030971302 0.106550557810192 no 3009 0.111003200863029 4274 79838 SGTC_484 loperamide 105 µM -1.22421349170846 0.105987904929329 no 3010 0.110435850448747 4367 3955 An opioid-receptor agonist. SGTC_2447 5741742 33.78 µM -1.22606999879891 0.105641159768122 no 3011 0.110086167290048 4348 1776504 SGTC_745 0469-0705 296 µM -1.22687594721964 0.105490886067751 no 3012 0.109934610069048 4356 3486736 SGTC_2933 9026794 32.47 µM -1.22717868092381 0.105434479595858 no 3013 0.109877720215246 4258 17586027 SGTC_2268 7933382 153.85 µM -1.22975189359953 0.104955909634954 no 3014 0.10939501381983 4338 935025 YOR257W CDC31 SGTC_129 0088-0017 176.636 µM -1.22998313277939 0.104912980555895 no 3015 0.109351710599557 4190 182446 SGTC_2570 licareol 100 µM -1.23369442605446 0.104225725102284 no 3016 0.108658395863251 4290 443158 SGTC_2847 9005661 71.43 µM -1.23548188586039 0.103895890963919 no 3017 0.10832560695917 4353 2991449 SGTC_2431 5490079 200 µM -1.23585505839724 0.103827126277286 no 3018 0.108256222420197 4360 5722345 SGTC_122 0236-0016 402.397 µM -1.23759428344097 0.103507073886967 no 3019 0.107933267582029 4310 6808838 SGTC_2841 9004761 38.96 µM -1.24019855707888 0.103029174890787 no 3020 0.107450980988678 4282 2991039 SGTC_41 0478-0632 82.643 µM -1.24049905827926 0.102974134521218 no 3021 0.10739543114872 4290 3750424 SGTC_502 l-744,832 89.3 µM -1.2420039415476 0.102698818565195 no 3022 0.107117553893998 4339 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2289 7946404 165.07 µM -1.24213380530381 0.102675085300754 no 3023 0.10709359882871 4307 1246120 YPR165W RHO1 SGTC_1011 4112-3381 17.4 µM -1.24382514777331 0.102366347812233 no 3024 0.106781961409086 4372 2877139 SGTC_70 0141-0289 43.283 µM -1.24483616464886 0.102182119585001 no 3025 0.106595989802375 4282 352408 SGTC_1384 3089-0840 101 µM -1.24518667653486 0.102118305393422 no 3026 0.106531569465814 4320 1069836 SGTC_3009 9080819 71.4286 µM -1.24738639857246 0.101718485875248 no 3027 0.106127925669678 4345 17027216 SGTC_1850 st056238 17 µM -1.25781323046824 0.099838813793721 no 3028 0.10422965486242 4350 5393177 SGTC_1091 telmisartan 47.6 µM -1.25928837016404 0.0995749486071391 no 3029 0.10396309617507 4371 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_3314 9135860 59.4275 µM -1.260660563586 0.0993299557572057 no 3030 0.103715584077284 4320 25252478 SGTC_2716 st080858 38.6235 µM -1.26125531745101 0.0992239047868684 no 3031 0.103608437084149 4307 5296050 SGTC_1669 st015249 58.4 µM -1.26220978832472 0.0990538855193394 no 3032 0.103436653732446 4432 722793 SGTC_2981 9013952 38.96 µM -1.26851206540092 0.0979366111970289 no 3033 0.102307572387754 4296 2996344 SGTC_59 0330-0160 1.33 µM -1.27803103232066 0.0962666314619476 no 3034 0.100619242311821 4306 4293482 SGTC_2093 5331342 194.4 µM -1.28067172949318 0.0958070853420451 no 3035 0.100154496824957 4395 33839 SGTC_1039 k821-0043 94 µM -1.28681977722952 0.0947434300268053 no 3036 0.099078555964427 4334 15992768 SGTC_1237 0330-0133 46.1 µM -1.28835265554544 0.0944795918938689 no 3037 0.0988116157017232 4287 X1237 YHR072W ERG7 SGTC_2654 protoveratrine a 100 µM -1.29040533455087 0.0941271349118184 no 3038 0.0984549804564443 4370 5702278 A heart drug and vasodilator. SGTC_629 3448-6466 76.7 µM -1.29359434831647 0.0935814882485971 no 3039 0.0979027878341462 4370 573744 SGTC_884 0851-0618 334 µM -1.29624590183195 0.0931295834684855 no 3040 0.0974453899849323 4372 9642473 SGTC_725 1497-0963 19 µM -1.29895564860412 0.0926694291310591 no 3041 0.0969795751256198 4468 3549977 SGTC_1792 st045773 43.6 µM -1.2997101800737 0.0925415985548114 no 3042 0.0968501599750412 4327 2919270 SGTC_1667 st014849 34.6 µM -1.30630578629919 0.0914297394191993 no 3043 0.095724295082708 4442 5348460 SGTC_758 0868-0029 16 µM -1.30680755989311 0.091345559628764 no 3044 0.0956390385013359 4365 762687 SGTC_668 1682-0499 62.6 µM -1.307126883635 0.0912920183700535 no 3045 0.0955848111584005 4358 682214 SGTC_2493 resveratrol 26.09 µM -1.30838405398949 0.0910814537569617 no 3046 0.0953715392206383 4289 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1624 st003710 6.25 µM -1.30957812990469 0.0908817906362791 no 3047 0.0951692954748789 4407 24207033 SGTC_2288 7946289 167.31 µM -1.31137565843883 0.0905818359979588 no 3048 0.094865439238741 4402 1246052 SGTC_3265 9137266 49.47 µM -1.31178709651543 0.0905132825587093 no 3049 0.0947959899280663 4330 17224265 SGTC_551 k048-0028 34.9 µM -1.31247534904276 0.090398692666035 no 3050 0.0946798990722574 4345 6836383 SGTC_16 erodoxin 22.806 µM -1.31262491629997 0.090373804875023 no 3051 0.0946546847112168 4389 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1296 1068-0102 11.9 µM -1.31365785770756 0.0902020637061208 no 3052 0.0944806843987944 4362 767053 SGTC_2881 9058953 51.95 µM -1.31569322467177 0.0898643647528327 no 3053 0.0941385145966889 4319 17122249 SGTC_691 1548-0686 185 µM -1.31630543866702 0.0897629730128051 no 3054 0.0940357730843908 4348 46495133 SGTC_2182 6325192 200 µM -1.3175148412544 0.0895629279352271 no 3055 0.0938330548229452 4389 736248 SGTC_2413 inermin 26.06 µM -1.31836117145247 0.0894231353031771 no 3056 0.0936913861867084 4430 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_199 4063-0024 41.6 µM -1.31914913260917 0.0892931297324603 no 3057 0.0935596300578058 4402 306215 SGTC_2555 cholic acid 100 µM -1.32035541566906 0.0890943777957948 no 3058 0.0933581908699374 4330 6708657 Influences liver metabolism. SGTC_559 1550-0661 158 µM -1.32133662544345 0.0889329527958789 no 3059 0.0931945734879059 4433 5830875 SGTC_3076 9116187 49.47 µM -1.32204026130594 0.088817327352914 no 3060 0.0930773722671496 4365 27241210 SGTC_3255 9139072 49.47 µM -1.32361881696755 0.0885583374220845 no 3061 0.0928148362923317 4378 17646060 SGTC_1688 st021091 57.6 µM -1.32396229045803 0.0885020591284388 no 3062 0.0927577844317262 4392 3656366 SGTC_485 niflumic acid 177 µM -1.32779637315546 0.0878756506093776 no 3063 0.092122692716013 4419 4488 A COX2 inhibitor. SGTC_2044 5102272 200 µM -1.3320795920462 0.0871797797958769 no 3064 0.0914170178379056 4373 592666 SGTC_189 3970-0742 2.116 µM -1.33507395620115 0.0866957514657765 no 3065 0.0909260712020915 4365 2891807 SGTC_1798 st045719 60.953 µM -1.33544065180042 0.0866366147322784 no 3066 0.0908660836238575 4344 3980186 SGTC_1692 fluoroquinolonic acid 71 µM -1.33951721790469 0.0859812192852833 no 3067 0.0902011765220679 4405 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_777 1315-0167 517 µM -1.33971423708016 0.0859496384681548 no 3068 0.0901691335659652 4418 4221767 SGTC_3095 9117207 49.47 µM -1.34032143622785 0.0858523632257041 no 3069 0.090070432632879 4379 17015229 SGTC_2803 7707263 71.43 µM -1.3421751823079 0.0855558969695327 no 3070 0.0897696006698575 4366 2199229 SGTC_2325 6158266 200 µM -1.34391855805574 0.085277782181768 no 3071 0.0894873620963923 4394 3623240 SGTC_1899 st063254 59.6 µM -1.34506542213725 0.0850951965551437 no 3072 0.0893020541963205 4353 3093813 SGTC_1831 st055328 12 µM -1.3459752862771 0.0849505508620163 no 3073 0.0891552434562946 4385 1103068 SGTC_2642 cholecalciferol 100 µM -1.34657922457707 0.0848546415647148 no 3074 0.0890578944722877 4390 9821465 A vitamin D precursor, similar to steriods. SGTC_1815 st051655 58.2 µM -1.34842973266678 0.0845612744217564 no 3075 0.0887601031600477 4343 5984156 SGTC_529 4076-0302 30.3 µM -1.35042732071138 0.0842454448485232 no 3076 0.0884394760865237 4363 5816522 SGTC_736 0958-0254 92.6 µM -1.35067963112303 0.0842056162526283 no 3077 0.0883990399341696 4461 6812352 SGTC_155 k072-0202 43.6 µM -1.35301231780123 0.0838380578746989 no 3078 0.0880258476297924 4381 5857737 SGTC_2947 9072639 7.68 µM -1.35517107510119 0.0834989801206884 no 3079 0.0876815289998585 4375 16488146 SGTC_610 4215-0184 155 µM -1.35726549561014 0.0831709937963137 no 3080 0.0873484333155998 4418 5605015 SGTC_3068 9116768 49.47 µM -1.3584466709289 0.0829864494338729 no 3081 0.0871609968010497 4362 41904888 SGTC_315 k915-0449 187 µM -1.35937153830906 0.082842165219414 no 3082 0.0870144426672646 4433 20970215 YNL149C PGA2 SGTC_1147 3809-1045 12.3 µM -1.36674133248768 0.0816991754321356 no 3083 0.0858531987602819 4415 325925 SGTC_361 000s-0510 1.45 µM -1.36790079859661 0.0815204400768531 no 3084 0.0856715648835601 4319 660 SGTC_1261 0712-0010 12.7 µM -1.36849911772607 0.0814283227153766 no 3085 0.0855779489883241 4394 2840123 SGTC_2641 levomentholum 100 µM -1.374538869659 0.0805028329100832 no 3086 0.0846372258737908 4421 16666 SGTC_114 0364-0001 490.298 µM -1.37468006265103 0.0804812929223459 no 3087 0.0846153274739484 4442 4003655 SGTC_1023 4482-3888 16 µM -1.37519569505303 0.0804026665433614 no 3088 0.0845353912989543 4423 3303168 SGTC_431 k089-0097 107 µM -1.37911881565336 0.0798063477431301 no 3089 0.0839290617330531 4155 5499420 SGTC_2125 5246583 200 µM -1.3796244766833 0.0797297306944227 no 3090 0.083851148567004 4428 835267 SGTC_632 0781-2353 4.65 µM -1.38205271900335 0.0793625818020098 no 3091 0.0834777572330208 4468 6811515 YHR007C ERG11 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.38428553457218 0.0790261120372941 no 3092 0.0831355207753638 4358 6708630 An antioxidant. SGTC_2921 7974240 10.71 µM -1.39335104371316 0.0776710944565989 no 3093 0.0817568311028727 4502 2979074 YDR527W RBA50 SGTC_3117 9124945 49.47 µM -1.39409386103846 0.0775608525664722 no 3094 0.0816446313820522 4339 17592065 SGTC_1861 st057647 17.4 µM -1.39546838348002 0.0773571723924971 no 3095 0.0814373212309818 4476 688668 SGTC_788 1182-0090 188 µM -1.39724342166655 0.0770947442209256 no 3096 0.0811701916391335 4428 5715185 SGTC_3346 9158254 43.5805 µM -1.40112571351252 0.0765231306276218 no 3097 0.0805882417858119 4457 17639500 SGTC_2144 5628481 200 µM -1.40277659657738 0.0762810402287228 no 3098 0.0803417339773226 4418 2818399 SGTC_1094 duloxetine 25.4 µM -1.40877806676631 0.0754058758343144 no 3099 0.0794504013041169 4463 60834 A selective serotonin reuptake inhibitor. SGTC_3356 9151811 4.48 µM -1.40984821559743 0.0752506285353083 no 3100 0.0792922530735788 4443 1859254 YPR165W RHO1 SGTC_2444 5485484 36.41 µM -1.41658877432767 0.0742783664324276 no 3101 0.0783015962359587 4504 6790631 SGTC_537 1334-0398 209 µM -1.4178443332035 0.074098328508708 no 3102 0.0781181087947752 4465 5846986 SGTC_1930 st074634 34.3 µM -1.42234636097196 0.073455510684648 no 3103 0.0774628632011562 4359 684253 YOR116C RPO31 SGTC_1680 diphenhydramine 100 µM -1.42394882165721 0.0732277368784096 no 3104 0.0772306437816876 4414 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.42519285061682 0.0730512834521609 no 3105 0.0770507312042418 4455 7104 SGTC_2910 7948405 25.97 µM -1.42537987710657 0.0730247837221433 no 3106 0.0770237108316472 4410 2971328 SGTC_2959 9079155 11 µM -1.42625883011349 0.0729003436457489 no 3107 0.0768968218530631 4463 16189457 SGTC_1035 k081-0041 55.2 µM -1.42676991972671 0.0728280594690175 no 3108 0.0768231121246777 4465 731709 SGTC_479 n-linoleoylglycine 10 µM -1.42910112724012 0.0724990490575689 no 3109 0.0764875847888834 4486 6433346 An anti-infammatory. SGTC_3173 9105693 49.47 µM -1.43230176037346 0.0720491902532738 no 3110 0.0760287397595249 4425 17096658 SGTC_137 0438-0332 85.389 µM -1.43721059084097 0.0713634011972761 no 3111 0.0753290822898244 4401 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1854 st056233 32.9 µM -1.4397091362683 0.0710162710807297 no 3112 0.0749748537251053 4381 5393174 SGTC_1925 st057770 10.1 µM -1.44295186879385 0.0705676844624422 no 3113 0.0745170151089573 4456 5989122 SGTC_563 tetrahydrosecaminediol 614 µM -1.44642600442209 0.0700895065109961 no 3114 0.0740288762371644 4503 334274 A psychoactive constituent of the cannabis plant. SGTC_2994 9053520 71.4286 µM -1.44905078401956 0.0697298894064426 no 3115 0.0736617004340271 4481 4647384 SGTC_588 3970-1144 52.9 µM -1.44962515669068 0.069651385208319 no 3116 0.0735815384294487 4356 1888707 SGTC_2800 7887935 81.82 µM -1.45284053061161 0.0692131698738221 no 3117 0.0731340178630738 4449 2961002 SGTC_2324 6149169 200 µM -1.45574021771391 0.0688198031116584 no 3118 0.0727322237802442 4401 2888231 SGTC_1464 k208-0027 110 µM -1.45657995086923 0.068706208763847 no 3119 0.0726161826646254 4468 X1464 SGTC_1719 st032227 49.2 µM -1.45748198194805 0.0685843482410094 no 3120 0.0724916907387667 4462 3125804 SGTC_2420 aureobasidin a 50 nM -1.4576741830735 0.0685584042530571 no 3121 0.0724651856461876 4537 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2627 acetyl isogambogic acid 100 µM -1.46143612955014 0.0680521261557887 no 3122 0.0719478958309329 4487 6857789 A caspase activator and apoptosis inducer. SGTC_1728 st035614 33.7865 µM -1.46392064356441 0.0677193491789698 no 3123 0.0716078161042673 4424 15945546 SGTC_3107 9121808 49.47 µM -1.46515007410841 0.0675551442771451 no 3124 0.0714399887162289 4429 662681 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.46559571470723 0.067495699767087 no 3125 0.0713792297045641 4434 2724 A muscle relaxant with antifungal properties. SGTC_358 0075-0058 9.45 µM -1.46625835411759 0.067407384287143 no 3126 0.0712889582385811 4446 1069125 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.46721550444814 0.0672799745956093 no 3127 0.07115872026211 4515 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_562 3772-2733 112 µM -1.46722227064806 0.0672790745857857 no 3128 0.0711578002464136 4463 2876874 YIL048W NEO1 SGTC_2238 6671620 73.2395 µM -1.46852668883437 0.067105740474365 no 3129 0.0709806060669045 4396 729941 SGTC_2950 9072895 21.46 µM -1.47001282386937 0.066908680484463 no 3130 0.0707791404245211 4425 17332245 SGTC_1959 st077091 55.8 µM -1.47008913168354 0.0668985742419275 no 3131 0.0707688077425866 4485 821356 YKL052C ASK1 SGTC_1675 st018485 24.5 µM -1.47203469706841 0.0666413013383999 no 3132 0.0705057541008027 4488 3323024 SGTC_475 α-linolenic acid 10 µM -1.47565712617996 0.0661643283877509 no 3133 0.0700179805186558 4476 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1450 4112-4260 37.6 µM -1.4760748451276 0.0661094969247342 no 3134 0.0699619004703629 4475 1633175 SGTC_901 1112-0062 60.1 µM -1.47624160622997 0.0660876170282429 no 3135 0.0699395219367602 4462 1908457 SGTC_2472 5377652 49.4 µM -1.47855537275837 0.0657846177983377 no 3136 0.0696295937578668 4529 1610903 SGTC_318 1488-0629 67.2 µM -1.47866634669829 0.0657701123155776 no 3137 0.0696147554556034 4522 3662576 SGTC_3181 9108277 49.47 µM -1.48133571082641 0.0654219443704794 no 3138 0.0692585684582458 4452 17097298 SGTC_2659 sanguinarine 24.21 µM -1.48189512582332 0.0653491608004657 no 3139 0.0691841010953249 4439 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2296 7971656 126.45 µM -1.48199412773829 0.0653362865444727 no 3140 0.0691709287349692 4485 666570 SGTC_3093 9117344 49.47 µM -1.48274897435624 0.0652381906128809 no 3141 0.069070558734637 4511 24824913 SGTC_2082 5219693 150 µM -1.4858414047739 0.0648375070686413 no 3142 0.068660537707134 4437 2834649 SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.49003026750773 0.0642978099335655 no 3143 0.0681081388347353 4589 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2023 5144124 124 µM -1.49150220404389 0.0641089953542632 no 3144 0.0679148464911196 4460 2830192 SGTC_2457 5731572 11.68 µM -1.49206243556603 0.064037244281747 no 3145 0.0678413891849749 4536 2865357 SGTC_2773 thioridazine 9.09 µM -1.49383216097089 0.0638109986303342 no 3146 0.0676097466271602 4470 5452 An antipsychotic. SGTC_1247 0448-0043 5.84 µM -1.49594797569201 0.0635413247183651 no 3147 0.0673336064107633 4480 3089013 YGL099W LSG1 SGTC_1574 spiramycin 23.7 µM -1.50183268046651 0.0627959448779066 no 3148 0.0665701629948316 4460 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2935 9038016 29.96 µM -1.50326411116782 0.0626156685245096 no 3149 0.0663854754506535 4449 6463195 SGTC_757 1066-0008 322 µM -1.50551026450717 0.0623335983627421 no 3150 0.0660964699469081 4523 6842497 SGTC_1361 1608-0041 5.61 µM -1.50656491283222 0.0622014987978313 no 3151 0.0659611083672982 4498 X1361 SGTC_679 0422-0091 41.4 µM -1.50804069942501 0.0620170164331231 no 3152 0.0657720554205376 4523 627384 YHR062C RPP1 SGTC_949 1165-0505 146 µM -1.50935493013219 0.0618530891921596 no 3153 0.0656040520956254 4469 6244267 SGTC_3043 9092303 49.47 µM -1.51030247378109 0.0617351097031795 no 3154 0.0654831304035239 4506 25236084 SGTC_158 k038-0087 26.446 µM -1.51302560711549 0.061397027826328 no 3155 0.0651365772404148 4416 X158 SGTC_982 1491-0518 27.5 µM -1.51576190177125 0.0610587704769861 no 3156 0.0647897843939921 4457 3091256 SGTC_1721 st082152 9.2685 µM -1.51708359041222 0.0608959075386345 no 3157 0.0646227903644691 4442 5296051 SGTC_1325 1431-0015 227 µM -1.51835835594029 0.0607391485889242 no 3158 0.0644620419306725 4496 1103340 SGTC_262 fenpropimorph 62.5 µM -1.51864096537811 0.06070443865266 no 3159 0.0644264468755368 4527 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1923 st058458 19.1 µM -1.52024991400649 0.0605071239600409 no 3160 0.0642240884306175 4497 3534982 SGTC_3139 9095020 49.47 µM -1.5287962613036 0.0594674355659306 no 3161 0.0631574797590828 4384 25236292 SGTC_142 0335-0849 62.6745 µM -1.53198807729022 0.0590827527264132 no 3162 0.0627626884676331 4478 3889043 YPR107C YTH1 SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.5330014644962 0.058961026749062 no 3163 0.0626377470359205 4508 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3193 9111931 49.47 µM -1.53365276435286 0.0588828978785838 no 3164 0.0625575500753334 4511 17087244 SGTC_3329 9141233 27.5565 µM -1.54115659491638 0.0579885992161182 no 3165 0.061639339267449 4485 4909101 YNL103W MET4 SGTC_1272 0839-0021 27 µM -1.55004765292259 0.0569428286827933 no 3166 0.0605650394336363 4553 5027250 SGTC_1770 st043884 66.3 µM -1.55492546565326 0.056375438916024 no 3167 0.0599819108052442 4534 670149 SGTC_740 k014-0057 261 µM -1.55535993841189 0.0563251177235561 no 3168 0.0599301848178401 4509 4012779 SGTC_2545 solidagenone 89.61 µM -1.555843843238 0.0562691129323226 no 3169 0.0598726148461819 4463 6708572 An anti ulcer agent SGTC_2028 5153890 36.43 µM -1.56066398772225 0.0557136465616388 no 3170 0.0593015262259725 4512 2830968 YPR165W RHO1 SGTC_1208 2323-2347 50.3 µM -1.5618345190446 0.0555794114053734 no 3171 0.0591634887822549 4537 5412760 SGTC_3113 9123498 49.47 µM -1.56735566932121 0.0549496911850587 no 3172 0.0585157898986737 4624 8897275 SGTC_1716 st033144 30.6155 µM -1.56844204397686 0.0548264500736447 no 3173 0.058389002766706 4491 674617 SGTC_552 k242-0005 476 µM -1.56914770796222 0.0547465148689969 no 3174 0.0583067627505246 4573 4088318 SGTC_115 0527-0192 112.043 µM -1.57305611411378 0.0543054509844851 no 3175 0.0578529127582496 4507 4233931 SGTC_830 4076-0286 57.8 µM -1.58033391609937 0.0534916462802448 no 3176 0.0570152083265813 4589 6866659 SGTC_2511 berberine 10.47 µM -1.58102610325395 0.0534147517465593 no 3177 0.0569360347017247 4521 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1696 st025591 34.7925 µM -1.58270238610308 0.0532288976981867 no 3178 0.0567446571036749 4535 2787147 SGTC_1150 3909-7983 10.9 µM -1.58627359264908 0.0528346578352199 no 3179 0.0563386299813908 4542 23965914 SGTC_2619 obliquin 87.91 µM -1.58995658101063 0.0524305078067357 no 3180 0.0559222961911335 4519 6708593 A bioactive alkalod. YER133W GLC7 SGTC_841 0251-0215 91.2 µM -1.592172291405 0.052188553294105 no 3181 0.0556729986541245 4581 3888614 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.59297375286802 0.052101252801312 no 3182 0.0555830396567027 4593 165521 SGTC_1210 3013-0140 750 nM -1.61552855877347 0.0496916622807858 no 3183 0.053098140442897 4575 905973 SGTC_123 0083-0120 66.675 µM -1.61865377032883 0.0493649163683494 no 3184 0.052760889441501 4534 16001701 SGTC_2040 5100729 123 µM -1.62004889132052 0.0492196090618828 no 3185 0.0526108874373633 4595 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2691 st077356 60.2 µM -1.62662835276711 0.0485389304252544 no 3186 0.0519080269285946 4529 2839272 SGTC_1031 k035-0009 16 µM -1.62931425635646 0.048263232610539 no 3187 0.0516232548428243 4591 5180959 SGTC_971 1315-0384 26.7 µM -1.62958774217126 0.0482352307429938 no 3188 0.0515943284059552 4581 6769120 SGTC_332 4112-0506 40.9 µM -1.63004989539042 0.0481879409996766 no 3189 0.051545476017555 4553 2790355 SGTC_1416 3966-0321 25.3 µM -1.63552413413863 0.0476306079744929 no 3190 0.0509696098228709 4609 582530 YLR208W SEC13 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.63923160791009 0.0472560905205683 no 3191 0.0505825167034213 4638 688801 SGTC_1200 1643-0193 18.4 µM -1.64108567438858 0.0470696857848224 no 3192 0.0503898160190153 4585 5403974 SGTC_1617 st002906 78 µM -1.64200612924049 0.0469773640288444 no 3193 0.0502943669301116 4548 5150859 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.64210826193631 0.0469671290606788 no 3194 0.0502837848876414 4551 6312947 SGTC_259 usnic acid 108.925 µM -1.6424586443891 0.0469320299647161 no 3195 0.0502474949941837 4594 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2664 lyso-paf C-16 73.48 µM -1.64803723690766 0.0463760305230967 no 3196 0.0496725150999248 4553 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1118 chelidonine 707.474 nM -1.64887169399945 0.0462933195278389 no 3197 0.0495869616113076 4566 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_472 calcifediol 10 µM -1.65157233582741 0.0460264448782418 no 3198 0.0493108816940664 4598 5283731 A vitamin D metabolite. SGTC_2787 5284540 71.43 µM -1.65890050155469 0.045308506360049 no 3199 0.0485679217883354 4563 736958 SGTC_756 0508-1999 28.3 µM -1.66204236226062 0.0450034709556752 no 3200 0.0482521404564544 4599 6753853 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.66506680516248 0.0447113988999577 no 3201 0.0479497142195611 4600 688788 SGTC_1868 st057644 42.7 µM -1.66804412690988 0.044425370318729 no 3202 0.0476534836816428 4607 688665 SGTC_1309 pyrazolanthrone 13.4 µM -1.66845268666232 0.0443862356532897 no 3203 0.047612948378286 4569 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1629 st005085 44.9 µM -1.6684845296919 0.044383186676049 no 3204 0.0476097902288804 4538 24207091 SGTC_2369 9071472 200 µM -1.66983803944923 0.0442537437869779 no 3205 0.0474757059935701 4585 17296037 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.67271161651259 0.0439799380518051 no 3206 0.0471920406417659 4608 688664 SGTC_343 4130-2827 29.8 µM -1.67702864934118 0.0435711637746066 no 3207 0.0467684398480289 4567 1118244 SGTC_369 0957-0393 4.5 µM -1.67909399427776 0.0433766862337691 no 3208 0.0465668632555701 4570 6997992 SGTC_1360 1598-0022 39.8 µM -1.68130421151862 0.0431693441070016 no 3209 0.0463519201401046 4590 761525 SGTC_540 1187-0821 17.3 µM -1.68435866736413 0.042884121664115 no 3210 0.0460561868241578 4513 847520 SGTC_2983 9022671 12.99 µM -1.68628825085605 0.0427047250763201 no 3211 0.0458701464672695 4568 6405161 SGTC_413 propylparaben 100 µM -1.68849294645833 0.042500493969918 no 3212 0.0456583209181929 4566 7175 A pharmaceutical preservative. SGTC_1259 0671-0132 43 µM -1.6911805683182 0.0422525963294199 no 3213 0.0454011605460062 4515 X1259 SGTC_1859 st055998 20 µM -1.693332589158 0.0420549453605871 no 3214 0.0451960891344675 4514 676301 SGTC_1214 0358-0031 63.7 µM -1.69639965630932 0.0417745465727257 no 3215 0.0449051093858344 4593 4301366 SGTC_2650 prasterone 100 µM -1.69697469089774 0.0417221444239369 no 3216 0.044850722774798 4613 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_3081 9117243 49.47 µM -1.70016876045497 0.0414320414494146 no 3217 0.0445495932700607 4551 45595589 SGTC_1404 3909-7820 48.3 µM -1.7070626671667 0.0408114697049678 no 3218 0.0439052025831687 4575 23741373 SGTC_1695 st026914 34.495 µM -1.71237713040166 0.0403382409519219 no 3219 0.0434135954149956 4598 3289191 SGTC_1914 st062367 72.6 µM -1.71373568545222 0.0402179856929089 no 3220 0.0432886399444386 4564 978205 SGTC_2339 9000433 200 µM -1.71961896024424 0.0397005725827128 no 3221 0.0427508636938144 4557 2988954 SGTC_104 0074-0074 590.992 µM -1.72253335055077 0.0394462742472584 no 3222 0.0424864733689587 4492 3943124 SGTC_1778 st046819 58.9 µM -1.72281041009279 0.0394221682423847 no 3223 0.0424614078111318 4633 671715 SGTC_1148 3909-7663 27.7 µM -1.72458609125707 0.0392679566902691 no 3224 0.0423010458882256 4618 4084526 SGTC_2531 methyl deoxycholate 70.07 µM -1.72671952068029 0.0390833255975395 no 3225 0.0421090240588327 4530 16667744 Haematoxylin. SGTC_2648 atorvastatin 78.68 µM -1.73088514974292 0.0387248612240123 no 3226 0.041736125386711 4604 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_704 1310-0270 142 µM -1.74231466220247 0.0377550576349384 no 3227 0.0407266995966972 4587 5718033 SGTC_1024 4507-0395 26 µM -1.74909364906106 0.0371892820806351 no 3228 0.0401374164299301 4632 4201836 SGTC_2105 5350118 200 µM -1.75664391593384 0.0365673102706939 no 3229 0.0394892612814761 4583 2133313 SGTC_471 1-acyl-paf 4 µM -1.75946445845608 0.0363371556071717 no 3230 0.0392493259520092 4587 16759367 SGTC_124 0136-0217 7.121 µM -1.76012768468678 0.0362832092607915 no 3231 0.0391930798605651 4653 3976905 SGTC_1213 1315-0166 115 µM -1.76105199118967 0.036208136202965 no 3232 0.0391148018300651 4594 768401 SGTC_3253 9135987 49.47 µM -1.76322110511511 0.0360324580352667 no 3233 0.0389316027728204 4627 4182430 SGTC_212 3807-4682 38.772 µM -1.76332291384712 0.036024229651574 no 3234 0.0389230214055652 4675 3125501 YBL034C STU1 SGTC_2423 st077119 87.2 µM -1.77792573870579 0.034859844629557 no 3235 0.0377080261423207 4545 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1878 temozolomide 1 mM -1.77969287513835 0.0347210580878008 no 3236 0.0375631185631841 4596 5394 DNA alkylating agent. SGTC_685 1278-0033 54.9 µM -1.78385809068226 0.034395726901086 no 3237 0.0372233636861846 4654 3590572 SGTC_1765 st044815 90.4 µM -1.78691097620224 0.034158870345122 no 3238 0.0369759390971835 4622 645695 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.78912717253187 0.0339877692526868 no 3239 0.0367971684914787 4615 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2140 5586273 200 µM -1.79093375207964 0.0338488145813374 no 3240 0.0366519633048455 4609 854421 SGTC_535 2293-4129 48.2 µM -1.79094988419041 0.0338475758740931 no 3241 0.0366506687888044 4602 396118 YIL048W NEO1 SGTC_3085 9117376 49.47 µM -1.79409438131796 0.0336068361474953 no 3242 0.0363990528579789 4667 16480349 SGTC_1650 st011916 45.8 µM -1.80193731009259 0.0330125249764198 no 3243 0.0357776346422026 4606 242528 SGTC_3034 9090421 49.47 µM -1.80827079712658 0.0325389391349728 no 3244 0.0352821823054318 4589 17173761 SGTC_3103 9120822 49.47 µM -1.8099526284491 0.0324141263293123 no 3245 0.0351515668317093 4617 17141819 SGTC_798 1287-0182 476 µM -1.817176689164 0.0318824954051692 no 3246 0.0345950315555748 4660 1649755 SGTC_230 MPP+ 141.667 µM -1.82130334120421 0.0315820538968715 no 3247 0.0342803794183417 4617 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2278 7948257 134.34 µM -1.82623785933891 0.031225871423744 no 3248 0.0339072204452052 4631 1247028 SGTC_3039 9090270 49.47 µM -1.82661601052733 0.0311987134004449 no 3249 0.0338787622011691 4633 17173750 SGTC_1012 4112-3522 18 µM -1.83958755667602 0.0302788884282329 no 3250 0.0329144062992157 4633 3112398 SGTC_3298 9116858 71.43 µM -1.84003091751871 0.0302478508115637 no 3251 0.0328818491672174 4668 2506942 SGTC_2456 5770359 74.46 µM -1.85120015162648 0.0294746035433701 no 3252 0.0320703819838463 4604 3118787 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.87854371038001 0.0276506520146153 no 3253 0.0301534116645193 4595 17037758 SGTC_1560 lithocholic acid 53.1 µM -1.88343625881444 0.0273344273873642 no 3254 0.0298206352168796 4606 9903 A bile acid which acts as a detergent. SGTC_2033 5192550 145 µM -1.88835754274395 0.0270193941022144 no 3255 0.029488983549572 4650 182073 SGTC_1355 1499-0035 1.68 µM -1.89916145196684 0.0263384067208337 no 3256 0.0287716256769273 4667 1548538 SGTC_2852 9023854 51.95 µM -1.8994006647557 0.0263234926113425 no 3257 0.0287559080834361 4658 19798528 SGTC_553 k007-0256 45.7 µM -1.90165950911161 0.0261830090401116 no 3258 0.0286078413119104 4690 6287000 SGTC_3292 9120825 59.784 µM -1.90263877758677 0.0261223008047361 no 3259 0.0285438477982835 4634 24824900 SGTC_165 k038-0023 64.381 µM -1.91056310100949 0.0256353619466173 no 3260 0.0280303750213866 4623 46368543 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.91352191598777 0.0254555058678563 no 3261 0.0278406352933847 4651 688669 SGTC_813 k007-0158 173 µM -1.9191313736608 0.0251174270092877 no 3262 0.0274838549213984 4659 6523916 SGTC_2083 5306046 65.942 µM -1.92202648823626 0.0249444176300165 no 3263 0.0273012124274724 4664 539837 SGTC_1424 4048-1941 275 µM -1.92781546571301 0.024601469290932 no 3264 0.0269390416672525 4720 X1424 SGTC_1263 0774-1208 64.8 µM -1.93227948199575 0.0243397234049159 no 3265 0.0266625097477851 4641 906585 SGTC_87 0100-0052 35.5 µM -1.93439145858642 0.024216705634471 no 3266 0.0265325079192419 4670 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_3235 9132602 49.47 µM -1.93890941109396 0.0239552980107283 no 3267 0.0262561849008339 4646 4912240 SGTC_2518 prenyletin 46.28 µM -1.94009753262931 0.0238869487351961 no 3268 0.0261839189144229 4705 3873459 A coumarin with calcium channel inhibitory activity. SGTC_969 1313-0238 134 µM -1.95468897998633 0.0230608278880175 no 3269 0.0253098957937362 4690 5212874 SGTC_2564 betulinic acid 100 µM -1.95498408942285 0.0230443711509056 no 3270 0.0252924741243724 4634 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2205 7238770 200 µM -1.96220360303326 0.0226448460092604 no 3271 0.0248693923157393 4700 279867 SGTC_1364 1653-0028 37.6 µM -1.96503321493264 0.0224898569976663 no 3272 0.0247051966772168 4692 5718652 SGTC_834 0312-0008 75.7 µM -1.97717080399777 0.0218351438635282 no 3273 0.024011163293965 4699 6385573 YIL048W NEO1 SGTC_2361 9034121 116 µM -1.98118166185943 0.0216223639698068 no 3274 0.0237854524858777 4689 6496917 SGTC_2605 digitonin 300 nM -1.98260878232731 0.0215470776781704 no 3275 0.0237055728129596 4657 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.98734694587275 0.0212987076057945 no 3276 0.0234419813123675 4730 4213774 SGTC_1383 3049-0032 20.7 µM -1.99120976873503 0.0210980175373643 no 3277 0.0232289151752075 4693 712864 SGTC_1655 st012546 55.1 µM -1.9947546176667 0.0209152576486135 no 3278 0.0230348246189016 4684 720985 YLR208W SEC13 SGTC_1709 st033179 39.1045 µM -2.01751637108275 0.0197733902404916 no 3279 0.0218208271696502 4689 573381 SGTC_2295 7971645 200 µM -2.02552077694053 0.0193846220022605 no 3280 0.0214069586097148 4708 2978226 YKL099C UTP11 SGTC_503 tyrphostin 8 294 µM -2.02987631899467 0.0191758183215872 no 3281 0.0211845563830686 4698 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1058 3448-5425 97.3 µM -2.06526650453875 0.0175490358021966 no 3282 0.0194488955062008 4667 7279705 SGTC_1804 st050076 49.1 µM -2.07302369998271 0.0172086456690044 no 3283 0.0190850369890817 4709 3895976 SGTC_2075 5212009 200 µM -2.07610649075992 0.0170749459866502 no 3284 0.0189420514971926 4667 780898 SGTC_2298 7976326 193.81 µM -2.07840899200318 0.0169756673182279 no 3285 0.0188358526084333 4683 2235818 SGTC_1053 3366-3204 134 µM -2.08072497432565 0.0168763056300721 no 3286 0.0187295433905898 4697 3632071 YPR165W RHO1 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -2.082615014287 0.0167955869336227 no 3287 0.0186431647671117 4669 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1805 st050013 60.3 µM -2.08890420593852 0.0165293652872215 no 3288 0.0183581735846474 4660 4037144 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -2.09104864004756 0.0164394209137888 no 3289 0.0182618520065115 4715 6708784 An antioxidant flavonoid SGTC_2285 7945142 200 µM -2.09431864684339 0.0163030732272522 no 3290 0.0181158021715575 4694 2970608 SGTC_60 0986-0278 202 µM -2.0994322246665 0.0160917969970878 no 3291 0.0178894082561561 4671 3110598 SGTC_2043 5101342 149 µM -2.1003779052411 0.0160529827586395 no 3292 0.0178478055254958 4708 678451 SGTC_1552 6-methylflavone 10.6 µM -2.12416446675066 0.0151027522029733 no 3293 0.0168281966795471 4695 689013 SGTC_436 n,n-dimethylsphingosine 3.3 µM -2.14890020328819 0.0141662732159624 no 3294 0.0158211558542589 4705 5282309 SGTC_333 3486-0131 40.1 µM -2.15647786522375 0.0138895881978141 no 3295 0.0155231851715217 4721 6744690 SGTC_307 1501-1223 22.3 µM -2.16323702417155 0.0136467338502234 no 3296 0.0152614769832058 4724 2830329 SGTC_1596 piperlongumine 63 µM -2.17662242568758 0.0131765966640681 no 3297 0.0147543752707218 4728 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2087 5276107 200 µM -2.18094387468258 0.0130278328549464 no 3298 0.0145937840049214 4718 144405 SGTC_2991 9074669 71.4286 µM -2.19047090135346 0.012704990020084 no 3299 0.0142450514500223 4664 17333109 SGTC_353 1988-1175 58.3 µM -2.19272723625055 0.0126295513227004 no 3300 0.0141635185937671 4587 2788357 SGTC_773 4358-1457 44.6 µM -2.20869608525407 0.0121066439772579 no 3301 0.0135978934553767 4721 1186886 SGTC_2792 7535235 81.82 µM -2.21888646547688 0.0117828548481582 no 3302 0.0132472247640201 4676 1281891 SGTC_1803 st050068 52.4 µM -2.22788172163141 0.0115033108002076 no 3303 0.0129442016848608 4720 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1527 coumarin 137 µM -2.2390101416375 0.0111654604052786 no 3304 0.0125776281442577 4732 323 A hepatotoxic, DNA x-linker. SGTC_2953 9074162 66.49 µM -2.2411201816907 0.0111023834946832 no 3305 0.0125091456292887 4709 16451992 SGTC_2861 9024595 19.48 µM -2.25913691725652 0.0105762999089402 no 3306 0.0119374346785406 4722 16482810 SGTC_1955 wogonin 32.4 µM -2.26960636390656 0.0102806809792365 no 3307 0.0116157385805892 4704 5281703 A flavanone. SGTC_24 0417-1663 219 µM -2.27929427030723 0.0100135748971442 no 3308 0.0113247892042413 4741 4329390 SGTC_1275 0867-0008 21.1 µM -2.28658305740918 0.00981662747727215 no 3309 0.0111100855443294 4722 3422836 SGTC_705 1124-0212 310 µM -2.30179529729187 0.00941645386674179 no 3310 0.0106733594461573 4723 9554485 SGTC_2522 biochanin a 4.94 µM -2.31509421443212 0.00907837592152077 no 3311 0.0103038882940936 4731 5280373 A possible chelator. SGTC_2269 7935389 174.42 µM -2.3294932432139 0.00872436089651168 no 3312 0.00991647526870127 4738 97605 SGTC_2058 5236698 133 µM -2.33185782866028 0.0086673971106956 no 3313 0.0098540858136809 4725 766665 SGTC_334 1502-1024 68.5 µM -2.39712591344771 0.00721863944652304 no 3314 0.00826212214979595 4748 3296216 SGTC_1702 st027038 51 µM -2.43885671191196 0.00640838790053216 no 3315 0.00736690456445057 4783 5521182 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -2.44374811466092 0.00631889418336452 no 3316 0.00726778547242609 4765 5393153 SGTC_1723 st034307 2.5525 µM -2.45131081576349 0.006182703073456 no 3317 0.00711684933568203 4738 867466 SGTC_3155 9099265 49.47 µM -2.464058097147 0.00595902409326245 no 3318 0.00686869212718925 4740 25236499 SGTC_1568 digitonin 820 nM -2.46572336520578 0.00593033964241524 no 3319 0.00683684458277238 4730 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_1738 st035555 74 µM -2.47215047623041 0.00582077675105851 no 3320 0.00671514861123407 4745 5331140 SGTC_3105 9121040 49.47 µM -2.47715776082549 0.00573666610182989 no 3321 0.00662166750282886 4751 41448907 SGTC_682 0kpi-0099 17 µM -2.54364402869126 0.00471782377751186 no 3322 0.00548514097238849 4758 1714895 YML126C ERG13 SGTC_577 r071-0003 38.6 µM -2.55217027973707 0.004599592061273 no 3323 0.00535270918376512 4757 4568517 YMR134W ERG29 SGTC_1682 st012968 530 nM -2.55536344956774 0.00455599829126316 no 3324 0.00530384862054826 4739 24207270 SGTC_3199 9111318 49.47 µM -2.55677264626816 0.00453687725095066 no 3325 0.00528241212011393 4716 8548020 SGTC_337 1315-0038 354 µM -2.57226293083993 0.00433136780695468 no 3326 0.00505180631493654 4763 1626437 SGTC_683 panaxydol 45 µM -2.58085614063654 0.00422098625701711 no 3327 0.00492778209024438 4765 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_276 colchicine 750 µM -2.59199681752479 0.00408162977085668 no 3328 0.00477103271440188 4787 2833 A microtubule depolymerizer. SGTC_1201 1889-3372 45.9 µM -2.5941080715781 0.00405568951221844 no 3329 0.00474183356940971 4737 5392199 SGTC_2473 5854593 8.94 µM -2.64318527885511 0.00349283171210484 no 3330 0.00410650395946925 4773 2872951 SGTC_341 1486-1430 230 µM -2.65996603176614 0.003317119652051 no 3331 0.00390742662875723 4757 2054753 YPL210C SRP72 SGTC_2474 5321570 43.32 µM -2.6716628925751 0.00319938513111633 no 3332 0.00377382149556839 4775 2841384 SGTC_357 1325-0123 420 µM -2.67192068513934 0.00319683321515911 no 3333 0.00377092361089101 4766 1098503 SGTC_288 1315-0019 35.1 µM -2.70294066594493 0.00290280838696901 no 3334 0.00343645069301002 4780 6811474 SGTC_1336 1486-0901 104 µM -2.70601580364068 0.00287503155967478 no 3335 0.00340479026251431 4780 5006114 SGTC_1621 st003705 32.4 µM -2.70656645911447 0.00287008302700431 no 3336 0.00339914867758445 4775 24207032 SGTC_426 0988-0037 14.6 µM -2.70746710157312 0.00286200584693281 no 3337 0.003389939504076 4756 5383008 SGTC_1280 0880-0253 10.1 µM -2.72233382682622 0.00273160676652519 no 3338 0.0032411312400236 4779 6836607 SGTC_3137 9097352 49.47 µM -2.72723961052741 0.00268976892275987 no 3339 0.00319333214469306 4742 44120435 SGTC_2430 5571206 200 µM -2.74950016072571 0.00250710217853174 no 3340 0.0029843116798812 4750 1731771 SGTC_127 0180-0333 59.125 µM -2.76610139736053 0.00237825903450517 no 3341 0.00283654460483353 4753 771601 SGTC_2801 7907800 81.82 µM -2.78030276605803 0.00227283038908045 no 3342 0.00271541193109359 4754 6620925 SGTC_2848 9016370 25.97 µM -2.79042024254154 0.00220032211824464 no 3343 0.00263198338843826 4744 7894410 SGTC_2515 chrysin 20.77 µM -2.79690175515435 0.00215497997422642 no 3344 0.00257976098020413 4788 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2113 5491891 107.031 µM -2.82192205313121 0.00198778630626757 no 3345 0.00238683891199506 4783 789979 SGTC_2109 5483026 200 µM -2.85224219962317 0.00180100513601871 no 3346 0.00217060048555642 4787 759335 SGTC_2529 gangaleoidin 93.61 µM -2.85910061847043 0.00176103381708505 no 3347 0.00212422003265413 4779 4565183 SGTC_2307 7538926 6.34 µM -2.8682371999279 0.00170903913058353 no 3348 0.00206382974596898 4755 96582 SGTC_676 falcarinol 140 µM -2.86867193967181 0.00170660029344635 no 3349 0.00206099545083461 4785 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_516 3992-2719 87.3 µM -2.8768488955907 0.00166131486355779 no 3350 0.0020083394247744 4750 5350887 YDR037W KRS1 SGTC_1211 1056-0033 32.3 µM -3.00619374881445 0.00107635300046728 no 3351 0.00132270190194765 4796 6741922 SGTC_3100 9120536 49.47 µM -3.05192278920593 0.000919654561020609 yes 3352 0.00113690290398944 4767 16421196 SGTC_1849 st056239 19.2 µM -3.1721213100469 0.00060228357964586 yes 3353 0.000756648896026894 4785 5393181 SGTC_1684 st024538 14.6195 µM -3.30691681653548 0.000368434938543704 yes 3354 0.000471644493116705 4805 6732859 SGTC_347 4534-1311 26.2 µM -3.45834531995709 0.000207659408842752 yes 3355 0.000271752132603764 4797 2862016 SGTC_2998 9066762 71.4286 µM -3.58420136891012 0.000126745897786236 yes 3356 0.000169055581874011 4792 4945196