SGTCid condition conc unit CSG2|YBR036C.score CSG2|YBR036C.strain.pval CSG2|YBR036C.strain.significant CSG2|YBR036C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2873 9040596 71.43 µM 19.4078485121765 2.83472477149157e-57 yes 1 3.312165841907e-84 1 6463863
SGTC_955 1216-0110 33 µM 16.779778300602 2.30824194072059e-43 yes 2 1.71557327412483e-63 6 3619719
SGTC_2658 polymyxin b sulfate 77.05 µM 14.5111904320235 5.82500008959643e-33 yes 3 5.14594044285273e-48 4 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_470 aa-861 153 µM 14.3242176176613 3.6000579753345e-32 yes 4 7.72288750239316e-47 3 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2867 9039098 71.43 µM 13.9547351994112 1.22966692757106e-30 yes 5 1.47196544454489e-44 1 6463460
SGTC_2232 chlorophetanol 41.5365 µM 13.7935037746143 5.57967394911961e-30 yes 6 1.39439541356033e-43 6 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_266 formosanin C 406 nM 12.4128102983895 1.15968942978589e-24 yes 7 1.11348284386134e-35 10 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2776 terbinafine 19.92 µM 11.6614157675356 5.34074740821132e-22 yes 8 1.00338759643077e-31 7 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_221 trifluoperazine 10.304 µM 10.5960444452863 1.68041513503626e-18 yes 9 1.55425710268873e-26 53 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2954 9074818 52.69 µM 9.61186668449661 1.46939644473809e-15 yes 10 3.56227334719064e-22 2 16648742
SGTC_2036 5160441 105 µM 9.45057322812569 4.19541710228721e-15 yes 11 1.68490076392697e-21 20 134534 YIL048W NEO1
SGTC_658 3253-0951 102 µM 9.36921437894225 7.07586224697187e-15 yes 12 3.65372007312959e-21 5 1184878
SGTC_733 4069-0007 56.1 µM 8.99881513300291 7.2330032337646e-14 yes 13 1.14083374242527e-19 20 5717425 YNL287W SEC21
SGTC_206 4546-0025 72.014 µM 8.71011578431499 4.15897696928676e-13 yes 14 1.51782280647793e-18 16 6620745 YIL048W NEO1
SGTC_439 amiodarone 34.4 µM 8.4947985288591 1.47933462265226e-12 yes 15 9.91382710826403e-18 19 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_384 k007-0144 5.16 µM 8.45844845449596 1.82723771838567e-12 yes 16 1.35479171496233e-17 13 6824886
SGTC_146 3448-8650 53.125 µM 8.26150615864705 5.65227438359172e-12 yes 17 7.19228636441206e-17 25 2891488 YIL048W NEO1
SGTC_3311 9131146 2.8755 µM 8.13425160980425 1.15673609511762e-11 yes 18 2.07245442453281e-16 33 4900406 YPR165W RHO1
SGTC_2582 agaric acid 100 µM 8.08837309656325 1.4935860228769e-11 yes 19 3.02334713009573e-16 102 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_568 1193-0097 7.48 µM 8.06925654557888 1.66074454843843e-11 yes 20 3.5363756176336e-16 36 3646150
SGTC_1026 k007-1105 30.6 µM 7.93154447938598 3.54100516745237e-11 yes 21 1.08218525317189e-15 18 7066794
SGTC_309 k408-0051 1.48 µM 7.86009838296348 5.21910717497799e-11 yes 22 1.91915933157336e-15 4 3640463
SGTC_232 clozapine 119 µM 7.85840929356207 5.26697804384752e-11 yes 23 1.94521145312472e-15 21 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1161 k007-0610 110 µM 7.51242735865065 3.28613047740665e-10 yes 24 2.90204749735752e-14 30 5843850
SGTC_208 k072-0098 12.366 µM 7.32272987540441 8.6737616109898e-10 yes 25 1.2148829657093e-13 6 5948901
SGTC_352 k048-0007 5.11 µM 6.91690516353864 6.39315825915014e-09 yes 26 2.30808442088847e-12 22 6811911
SGTC_2006 4011487 200 µM 6.89891554833008 6.9677274830505e-09 yes 27 2.62005047806921e-12 36 45595294
SGTC_888 0916-0002 6.97 µM 6.79767187211452 1.12649743968996e-08 yes 28 5.31616357495061e-12 19 2802138 YIL048W NEO1
SGTC_2736 butenafine 14.65 µM 6.72308905289769 1.59798809493533e-08 yes 29 8.89558856802602e-12 6 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3189 9110682 49.47 µM 6.72117098865511 1.61234432599801e-08 yes 30 9.01349481818584e-12 5 17122418
SGTC_813 k007-0158 173 µM 6.55952235004885 3.39685025005793e-08 yes 31 2.69902014810905e-11 9 6523916
SGTC_993 3909-8757 62.7 µM 6.4728562806903 5.02971126530235e-08 yes 32 4.8083708054394e-11 2 4288324 YLR208W SEC13
SGTC_2359 9039622 200 µM 6.46810906061308 5.13829835655269e-08 yes 33 4.96184340828819e-11 4 6463596
SGTC_823 0417-1665 178 µM 6.32495830408264 9.71755518230597e-08 yes 34 1.2665048539001e-10 15 3429856
SGTC_1781 st038725 66.3 µM 6.27223864335827 1.22467027320574e-07 yes 35 1.77946767594658e-10 54 4270275 YIL048W NEO1
SGTC_1241 0364-0022 50.8 µM 6.21501311674399 1.57102026771311e-07 yes 36 2.56601813848199e-10 7 4563895
SGTC_1797 st048695 56.8 µM 6.0614123136199 3.03352934216733e-07 yes 37 6.74657215048401e-10 41 592262 YIL048W NEO1
SGTC_1941 st076221 61.8 µM 5.74415753817769 1.12512526788973e-06 yes 38 4.61898763488506e-09 34 2828568
SGTC_664 1222-0054 14.9 µM 5.70437854993922 1.32003333519279e-06 yes 39 5.83841573311395e-09 19 6813991
SGTC_3188 9110789 49.47 µM 5.59220885585452 2.05991438155774e-06 yes 40 1.12099449222863e-08 4 849217
SGTC_1803 st050068 52.4 µM 5.58790420355447 2.09505663736658e-06 yes 41 1.14913178751214e-08 95 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2293 7624732 200 µM 5.54291961506966 2.49838462172017e-06 yes 42 1.48734722314916e-08 4 894453
SGTC_2211 7117706 200 µM 5.50910255112394 2.84949583025842e-06 yes 43 1.80333876096499e-08 3 822771
SGTC_2934 9036370 36.88 µM 5.49317307899678 3.03080678238619e-06 yes 44 1.97387774767412e-08 13 6462800
SGTC_15 0266-0086 27.098 µM 5.4880660138187 3.09123707510994e-06 yes 45 2.03179106098461e-08 25 1712902 YIL048W NEO1
SGTC_103 0844-0104 51.839 µM 5.41021125850618 4.16809536995369e-06 yes 46 3.14752219396112e-08 90 5375804
SGTC_1344 1488-0097 29.1 µM 5.34599523717799 5.31777472635808e-06 yes 47 4.49607863014104e-08 5 747966
SGTC_940 3232-1287 54.8 µM 5.30060419397258 6.3068887004311e-06 yes 48 5.77100358669691e-08 14 1585493 YIL048W NEO1
SGTC_2858 9025781 8.96 µM 5.08188149513729 1.40850379058902e-05 yes 49 1.86857273254e-07 65 4894980 YPL153C RAD53
SGTC_2482 5981709 142.65 µM 4.98260071177465 2.00796735628712e-05 yes 50 3.13676597678571e-07 22 877755
SGTC_1673 st016611 27.3 µM 4.96060431592219 2.17023011216949e-05 yes 51 3.51371050257281e-07 21 5226799
SGTC_373 0844-0104 25.9 µM 4.84439844905191 3.25516831972693e-05 yes 52 6.34979253994325e-07 32 5375804
SGTC_1785 bathophenanthroline 24 µM 4.79767094596967 3.82223184850873e-05 yes 53 8.0260598718655e-07 26 72812 An iron chelator.
SGTC_1130 3454-2858 15.9 µM 4.79647179586882 3.83794611661543e-05 yes 54 8.07423412082412e-07 58 715628 YIL048W NEO1
SGTC_2567 aureobasidin a 60 nM 4.78041851384826 4.0542871341207e-05 yes 55 8.74653258900524e-07 62 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2120 5538279 151.968 µM 4.74064692385298 4.64098240634515e-05 yes 56 1.06518450228911e-06 6 2058197
SGTC_121 0557-0495 61.343 µM 4.66126638230921 6.05972687237529e-05 yes 57 1.57134826802269e-06 36 3104427
SGTC_2020 4017018 200 µM 4.61291907009111 7.11467680762992e-05 yes 58 1.9852646519977e-06 8 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2664 lyso-paf C-16 73.48 µM 4.58725293362807 7.74275951066504e-05 yes 59 2.2455821886037e-06 6 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_637 1181-0519 7.26 µM 4.48046821032651 0.000109598885397946 yes 60 3.72397364900776e-06 84 6252091 YGR060W ERG25
SGTC_313 3474-0040 5.03 µM 4.42064030209501 0.000132734389724464 yes 61 4.92044330307867e-06 55 1043375 YIL048W NEO1
SGTC_2016 5121758 140 µM 4.41856896083646 0.00013361202789791 yes 62 4.96782893871216e-06 34 2795203
SGTC_2882 9058044 58.44 µM 4.38331162139677 0.000149410740406912 yes 63 5.84443628077277e-06 10 18076804
SGTC_2581 avocatin a 64 µM 4.30519230912176 0.000190856206260355 yes 64 8.34203683063288e-06 42 6710728 A skin care supplement.
SGTC_3166 9102297 49.47 µM 4.27383095030606 0.000210338837268891 yes 65 9.60713684338585e-06 28 25237072
SGTC_1524 corynanthine 62.1 µM 4.23578316421584 0.000236467046282252 yes 66 1.13878242097362e-05 11 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_3152 9099253 49.47 µM 4.19770135638249 0.000265625644742419 yes 67 1.34818941384883e-05 116 25236131
SGTC_502 l-744,832 89.3 µM 4.1892505216627 0.000272535197949185 yes 68 1.39938643132759e-05 34 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_700 3453-2283 142 µM 4.1727968974665 0.000286470837113581 yes 69 1.50441569022817e-05 21 565664
SGTC_2968 9090663 33.37 µM 4.12396421020531 0.000331835194947987 yes 70 1.86203392778752e-05 24 25236811
SGTC_2459 5811157 9.22 µM 4.11717106637007 0.000338650620980586 yes 71 1.91775691000563e-05 11 2870684 YBR192W RIM2
SGTC_1633 st005664 67.9 µM 4.00848102870893 0.000466990529915057 yes 72 3.0555273480269e-05 26 2063822
SGTC_2055 5235184 200 µM 3.9422514528051 0.000565933788804897 yes 73 4.03601414336054e-05 29 2836034
SGTC_834 0312-0008 75.7 µM 3.92894066474647 0.000588023498951422 yes 74 4.26604433329607e-05 38 6385573 YIL048W NEO1
SGTC_1372 2752-0194 270 µM 3.84613586825824 0.000744319571423165 yes 75 5.99976201851507e-05 18 823334
SGTC_2220 6782180 200 µM 3.84354275603057 0.000749781968534644 yes 76 6.06354299118782e-05 8 833803
SGTC_3220 9131269 49.47 µM 3.82604886029339 0.000787608664253797 yes 77 6.51082274697796e-05 13 17722206
SGTC_1991 st073000 8.92 µM 3.8211102370343 0.000798601024428775 yes 78 6.64261239688091e-05 85 4301969 YIL048W NEO1
SGTC_2603 homopterocarpin 100 µM 3.75998185822106 0.000946863693389209 yes 79 8.49628396782567e-05 49 101795 A weak amylase inhibitor.
SGTC_2208 7283366 200 µM 3.75728450405458 0.000953954314839126 yes 80 8.58835870155273e-05 12 898663
SGTC_261 5-fluorouridine 15.376 µM 3.75575147296642 0.000958005943629816 yes 81 8.64110646623014e-05 17 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2472 5377652 49.4 µM 3.7515488817532 0.000969194094270939 yes 82 8.78727393756396e-05 68 1610903
SGTC_3350 9150499 3.57 µM 3.72364225385891 0.00104658292048978 no 83 9.8184565994563e-05 64 4910996 YPR165W RHO1
SGTC_1476 4112-3294 3.34 µM 3.70405520104817 0.00110424223704816 no 84 0.000106090027281846 24 704369
SGTC_825 1988-2224 89.6 µM 3.70336892814337 0.00110631425882697 no 85 0.000106377564077131 41 1180859
SGTC_301 4119-0100 24.5 µM 3.70177846031855 0.0011111299660539 no 86 0.000107046759136426 87 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_79 0052-0007 94.094 µM 3.68030631456595 0.00117805230693468 no 87 0.000116476973552083 48 2801472
SGTC_1521 st012942 49.4 µM 3.67293134787204 0.00120187624919162 no 88 0.000119891959863169 39 24207259
SGTC_2294 7971431 200 µM 3.64356913598812 0.00130116491081618 no 89 0.000134441692648999 18 5741572
SGTC_2475 5812728 15.03 µM 3.6189027772179 0.00139031022866761 no 90 0.000147927376666008 28 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_845 0330-0138 4.51 µM 3.61295488836575 0.00141262472602066 no 91 0.000151363693550739 27 9039800
SGTC_3219 9131112 49.47 µM 3.56189146270854 0.00161808344237105 no 92 0.000184096302234167 45 17612988 YMR079W SEC14
SGTC_1824 st053723 68.6 µM 3.55877304226279 0.00163147209433071 no 93 0.000186295659594912 46 675225
SGTC_2941 9056145 11.23 µM 3.53183541799815 0.00175139650626087 no 94 0.00020634305898296 29 2119517
SGTC_3207 9114163 49.47 µM 3.52617637912702 0.00177758791203763 no 95 0.000210803041206826 45 849233
SGTC_1721 st082152 9.2685 µM 3.52474938022544 0.00178424842241333 no 96 0.000211941809263732 32 5296051
SGTC_55 0767-0285 6.563 µM 3.52319671359808 0.00179152126951345 no 97 0.000213187386084586 56 3116166
SGTC_3191 9110352 49.47 µM 3.51662176028609 0.00182261883154418 no 98 0.000218538069107021 23 17122424
SGTC_2824 7998404 51.95 µM 3.50913925285306 0.00185860547820326 no 99 0.000224779730701083 46 837851
SGTC_1311 1190-0148 100 µM 3.49860326879571 0.00191037309450543 no 100 0.000233850965990318 40 1961333
SGTC_147 4466-0538 29.23 µM 3.44639184589884 0.00218676412204946 no 101 0.00028406296166616 42 6742687 YHR072W ERG7
SGTC_161 4065-0411 162.148 µM 3.43317548673529 0.00226224916424392 no 102 0.000298277924596114 92 1906281 YLR208W SEC13
SGTC_656 4090-1979 187 µM 3.39044256921651 0.00252274858209 no 103 0.000348899366852488 37 22330961
SGTC_3080 9117754 49.47 µM 3.38420421918721 0.00256296664792698 no 104 0.000356924430260004 36 9550191
SGTC_493 zm226600 134 µM 3.35949106594163 0.002728046803594 no 105 0.00039043088024653 32 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2596 sinensetin 100 µM 3.33125954086572 0.00292832905361372 no 106 0.000432269777554909 59 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_3131 9127911 49.47 µM 3.31380161172849 0.00305871897795531 no 107 0.000460183919825824 49 45595681
SGTC_2056 5235370 200 µM 3.31073737974281 0.00308213720081079 no 108 0.00046525246081545 66 5511916
SGTC_3276 9139060 49.47 µM 3.30782854323272 0.00310451707385791 no 109 0.000470111771391667 15 4870619
SGTC_1300 1094-0077 113 µM 3.29114837991647 0.00323569844140166 no 110 0.000498896341671179 29 5532636
SGTC_3284 9108171 64.8615 µM 3.28890360641251 0.0032537280612341 no 111 0.00050289231792235 44 8687505
SGTC_539 4859-0462 2.54 µM 3.26065854472406 0.00348843504029316 no 112 0.00055576903131021 51 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2072 5231554 129 µM 3.25537881038217 0.00353395806395941 no 113 0.000566206069498927 25 789545
SGTC_683 panaxydol 45 µM 3.23641874880227 0.00370186551258299 no 114 0.000605198396096376 63 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2114 5491910 81.25 µM 3.23461934988409 0.00371816671494013 no 115 0.000609025004737506 36 2849228
SGTC_1516 st013856 110 µM 3.21629510463546 0.00388787340058659 no 116 0.000649286123189013 31 5281404 A mutagen and neurotoxin.
SGTC_3317 9138495 8.753 µM 3.20993704452627 0.00394835957836709 no 117 0.000663820233371111 44 17020139
SGTC_2893 9048488 25.97 µM 3.19969616710706 0.00404755776066264 no 118 0.000687862654571293 48 6467338
SGTC_2576 guaiol 23.12 µM 3.17403373551588 0.00430600544806003 no 119 0.000751681081748203 64 227829
SGTC_425 3825-7017 13.1 µM 3.16244452816147 0.00442748231522652 no 120 0.000782252697495871 64 3397440
SGTC_2332 7982454 138.89 µM 3.16007486197558 0.0044526946518313 no 121 0.000788643031364095 95 2981748
SGTC_2333 9017922 200 µM 3.12421072556087 0.00485024657478494 no 122 0.000891413634058796 60 3163164
SGTC_2250 alverine citrate 130 µM 3.11783045526437 0.00492419668184871 no 123 0.000910937883835133 244 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_535 2293-4129 48.2 µM 3.10128763556639 0.00512063525080274 no 124 0.000963405126237477 117 396118 YIL048W NEO1
SGTC_1887 st057648 70.8 µM 3.08698765677692 0.00529603031448995 no 125 0.00101097996206575 44 688672
SGTC_2028 5153890 36.43 µM 3.0731136570348 0.00547128695662045 no 126 0.00105918894406331 62 2830968 YPR165W RHO1
SGTC_2424 5537928 59.2 µM 3.05940675189176 0.00564947494076521 no 127 0.00110887907931056 87 5382802
SGTC_371 0195-0006 7.36 µM 3.05106504151792 0.00576042117187637 no 128 0.00114015586008295 51 3928593
SGTC_2790 5423970 71.43 µM 3.03470027016636 0.00598370695432956 no 129 0.00120387419862671 116 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2721 ifenprodil 61.44 µM 3.03388952458906 0.0059949658428357 no 130 0.00120711410107091 58 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2541 muurolladie-3-one 83.07 µM 3.02280689886164 0.00615076494744959 no 131 0.00125220997466735 69 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1420 4'-methoxyflavone 42 µM 3.02147302014239 0.00616975633638077 no 132 0.00125774028211097 36 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1719 st032227 49.2 µM 3.01988851975869 0.0061923834913014 no 133 0.00126433870445065 70 3125804
SGTC_2619 obliquin 87.91 µM 3.01640312480583 0.00624241484167084 no 134 0.00127896469492047 218 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1307 1187-1599 12.2 µM 3.00462983406976 0.00641407227555993 no 135 0.00132952122137298 41 1538471
SGTC_2688 kanamycin b 96.69 µM 3.00247664767801 0.00644591417052776 no 136 0.00133896259090886 535 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1414 3917-0015 5.4 µM 2.97539138056251 0.00685856692980412 no 137 0.0014630747786969 39 6618702
SGTC_2188 6126565 140.678 µM 2.97016623789433 0.00694080576179803 no 138 0.00148819318357709 44 874518
SGTC_1044 1222-0021 1.78 µM 2.96876537977653 0.00696300142396256 no 139 0.00149499397356566 88 4306703
SGTC_1985 st071382 65.5 µM 2.96384955640704 0.00704138590909028 no 140 0.00151908390239278 59 6123237
SGTC_1314 1222-0010 41.1 µM 2.95672778167869 0.00715632626554317 no 141 0.00155461241705423 42 3526027
SGTC_2972 9093619 59.92 µM 2.94245494377696 0.00739167221306062 no 142 0.00162810583006039 55 25236256
SGTC_651 3253-0966 34.4 µM 2.9230456774529 0.00772264632696231 no 143 0.00173312831363935 82 781462
SGTC_3269 9137823 49.47 µM 2.90536333027105 0.00803545551661559 no 144 0.00183413505047973 57 17682936
SGTC_1308 1187-1617 41.4 µM 2.88517153859196 0.00840623179272503 no 145 0.00195600220631055 108 2882570
SGTC_119 0121-0043 24.815 µM 2.87291289351067 0.008638588503773 no 146 0.00203353118243481 212 1092378
SGTC_2925 9010536 32.5 µM 2.85599953416931 0.00896841245883264 no 147 0.00214507881807388 115 2994177
SGTC_3176 9106582 49.47 µM 2.85274116650504 0.00903320545969788 no 148 0.00216719547900244 10 17018027
SGTC_2988 9073640 71.4286 µM 2.83230872689501 0.00944892973032556 no 149 0.00231066027421265 66 9102229
SGTC_3303 9125618 40.5795 µM 2.83154940515128 0.0094646964094732 no 150 0.00231615383208774 128 22695467
SGTC_1391 3442-0225 151 µM 2.81594997014916 0.00979373548788874 no 151 0.00243166197133934 62 5227075
SGTC_1671 st016596 74.5 µM 2.81418372439891 0.00983161337365434 no 152 0.00244506355947454 68 2829167
SGTC_98 0074-0023 107.663 µM 2.78508920177178 0.0104742238357509 no 153 0.00267564996864186 100 3563821
SGTC_2942 9052777 62.25 µM 2.77581128185603 0.0106867011317796 no 154 0.00275320800311698 110 6469503
SGTC_509 pifithrin 175 µM 2.77552249231278 0.0106933746189446 no 155 0.00275565435125053 36 4817 A p53 inhibitor.
SGTC_3018 9082602 49.47 µM 2.75831526228455 0.0110976137998853 no 156 0.00290500672906651 96 17332089
SGTC_3044 9093193 49.47 µM 2.74104748265821 0.0115165706514578 no 157 0.00306218281518799 101 25236277
SGTC_2202 7226349 200 µM 2.70195834157754 0.0125160148660168 no 158 0.00344661992435806 60 844334
SGTC_1212 0520-0165 585 µM 2.69471071775694 0.0127093556383581 no 159 0.00352248826985359 114 5403258
SGTC_3185 9108267 49.47 µM 2.69248563524278 0.0127692290635491 no 160 0.00354607953371063 99 4910486
SGTC_2952 9073731 13.78 µM 2.6599018830442 0.0136743552759952 no 161 0.00390817089333423 135 16457353
SGTC_1027 k015-0025 8.67 µM 2.64390242184688 0.0141387062567431 no 162 0.00409781394328129 101 3598955
SGTC_2125 5246583 200 µM 2.62713506565629 0.0146398617454597 no 163 0.00430535740767564 133 835267
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 2.62633579266587 0.0146641279590843 no 164 0.0043154812641817 109 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_124 0136-0217 7.121 µM 2.62416743918144 0.0147301343048549 no 165 0.00434305360133917 142 3976905
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 2.6227958520504 0.0147720182988558 no 166 0.00436057561113962 81 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2865 9030313 51.95 µM 2.61891021807912 0.0148912300100179 no 167 0.00441055802781023 78 42562754
SGTC_106 0092-0003 11.579 µM 2.59783977461251 0.0155521778459732 no 168 0.00469061283197167 72 1072148
SGTC_70 0141-0289 43.283 µM 2.57824944154634 0.0161891271542111 no 169 0.00496511430984502 358 352408
SGTC_2071 5230951 39.92 µM 2.57298809785373 0.0163639518821309 no 170 0.00504123374861302 95 1799272
SGTC_3108 9121785 49.47 µM 2.5585704790138 0.0168513294675697 no 171 0.00525517563360421 93 17140271
SGTC_1295 1013-0063 9.78 µM 2.55448449440648 0.0169916908240158 no 172 0.00531725830650886 104 6826038
SGTC_701 4424-0219 185 µM 2.55015487355539 0.0171415110005841 no 173 0.0053837537311655 108 2911779
SGTC_2466 5983409 37.09 µM 2.548903315495 0.0171850290965265 no 174 0.00540311272339623 98 2879657
SGTC_2889 9059656 51.95 µM 2.54660609252835 0.0172651518315995 no 175 0.00543880705597532 82 3949838
SGTC_1547 harmine 94.2 µM 2.54151508242134 0.0174438544381888 no 176 0.00551865920433441 155 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2344 7990960 76.95 µM 2.54089375046174 0.017465771946133 no 177 0.00552847572852023 104 140813
SGTC_1423 4048-0112 5.59 µM 2.54013024150772 0.0174927369481866 no 178 0.0055405597718664 106 X1423
SGTC_1612 st002233 45.4 µM 2.53643496380231 0.0176237466633292 no 179 0.00559937708577251 100 1035021
SGTC_2449 5812982 45.77 µM 2.52895324431391 0.0178915638045293 no 180 0.00572016331778251 74 776185
SGTC_959 1222-0044 107 µM 2.52246272762711 0.0181267039115222 no 181 0.00582681496745219 103 6083612
SGTC_2796 7949634 45.45 µM 2.492544623804 0.0192449263750608 no 182 0.00634156961037397 115 2971588
SGTC_9 0092-0002 10.449 µM 2.48639266497315 0.0194819898325287 no 183 0.00645227454511382 125 759368
SGTC_901 1112-0062 60.1 µM 2.48057662316173 0.0197083853498228 no 184 0.00655850342068068 87 1908457
SGTC_1854 st056233 32.9 µM 2.45443343724135 0.0207538131344327 no 185 0.00705533927094189 111 5393174
SGTC_2471 5466956 24.79 µM 2.44385969583842 0.02118978429607 no 186 0.00726553818234706 77 724419
SGTC_270 tamoxifen 5.46 µM 2.43939620615644 0.0213761325179839 no 187 0.00735591413656618 152 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1242 0402-0103 60.1 µM 2.4373585940575 0.021461661246657 no 188 0.00739749973896498 116 432868
SGTC_968 1309-0633 340 µM 2.43603554273545 0.0215173510564202 no 189 0.00742461268916473 95 3761976
SGTC_877 0771-0151 33.1 µM 2.40762151460392 0.0227431534064899 no 190 0.00802840885066792 117 6166523
SGTC_382 3229-0966 23.2 µM 2.40127456546894 0.0230248635673179 no 191 0.00816903624917726 125 5722370
SGTC_2780 5215298 71.43 µM 2.40037167414403 0.0230651762876916 no 192 0.00818921616814704 168 2834131
SGTC_802 4112-3352 742 µM 2.39943763566691 0.0231069422127666 no 193 0.00821013831167283 139 704594
SGTC_143 4032-1194 15.74 µM 2.39768719300214 0.0231853855047004 no 194 0.00824947411900568 211 1806963
SGTC_925 2064-1272 59.6 µM 2.39556027106598 0.0232810017028727 no 195 0.00829749283337583 132 6815817
SGTC_1626 st003712 1.76 µM 2.39120198845612 0.0234779662578667 no 196 0.00839665553528024 135 24207035
SGTC_2070 5230947 200 µM 2.38987506191106 0.0235382119405397 no 197 0.00842705257637141 117 2835538
SGTC_82 0054-0107 293.755 µM 2.3821034973119 0.0238936767575062 no 198 0.00860702932040952 86 3104697
SGTC_3178 9107506 49.47 µM 2.38205151475067 0.0238960695030869 no 199 0.00860824441648281 121 8897194
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 2.37986124367029 0.0239970703551062 no 200 0.00865957908668738 130 688751
SGTC_3098 9119039 49.47 µM 2.37188168836519 0.0243680738684823 no 201 0.00884887834510902 144 17161528
SGTC_2189 6047310 154.431 µM 2.37131631128134 0.0243945423597278 no 202 0.00886242735581437 105 711535
SGTC_2854 9024559 71.43 µM 2.36800372990257 0.024550108428253 no 203 0.00894217779969505 148 3163529
SGTC_491 tetrandrine 80.3 µM 2.36451108145435 0.0247150316691561 no 204 0.00902694361537638 81 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_90 0870-0863 4.608 µM 2.35374339619628 0.0252293433585253 no 205 0.00929271797582594 179 1738164
SGTC_2195 6536160 144.242 µM 2.34228185297624 0.0257866200716823 no 206 0.00958311736219099 115 3834386
SGTC_3275 9138069 49.47 µM 2.34082664029063 0.0258581060982207 no 207 0.00962054955340964 96 17617007
SGTC_1013 4112-3890 241 µM 2.33596475936583 0.0260981452301041 no 208 0.00974653914619053 159 705171
SGTC_2827 7993847 71.43 µM 2.33352174118749 0.0262194628238267 no 209 0.00981038930460675 130 2985692
SGTC_1047 2043-3044 82 µM 2.33141975647218 0.0263242221059232 no 210 0.00986561838686785 170 669592
SGTC_2698 st077697 67.5 µM 2.32628735380901 0.0265814830332118 no 211 0.0100016131073768 130 3154499
SGTC_617 3770-0098 35 µM 2.30387407495019 0.0277296842319369 no 212 0.0106148566949998 120 5962639
SGTC_2756 carbadox 75.1 µM 2.29963247406969 0.0279515613771192 no 213 0.0107345253438061 227 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3025 9087895 49.47 µM 2.29877241115207 0.027996730908977 no 214 0.0107589331061229 153 17173641
SGTC_2088 5278280 127.392 µM 2.29641555143831 0.0281208221548897 no 215 0.0108260663116533 182 791502
SGTC_2153 5569715 200 µM 2.29531184312723 0.0281790908558239 no 216 0.0108576296922354 112 2054701
SGTC_496 calpeptin 138 µM 2.29459687458422 0.0282168902154047 no 217 0.0108781187781301 135 73364 A calpain inhibitor.
SGTC_2043 5101342 149 µM 2.29270977311893 0.0283168613235033 no 218 0.010932359753645 158 678451
SGTC_2145 5634607 200 µM 2.29005925003291 0.0284577730850078 no 219 0.0110089410988185 106 308662
SGTC_1413 3910-0535 34.4 µM 2.2836667457513 0.0288000242673902 no 220 0.0111955619192412 128 2876951
SGTC_2701 st077767 14.721 µM 2.27752744188525 0.0291319338551455 no 221 0.0113773739126936 198 5721188
SGTC_2821 7996764 71.43 µM 2.27383755308244 0.0293329451622046 no 222 0.0114878777254078 204 2987135
SGTC_1776 st049249 45.9 µM 2.26814542161108 0.0296452890424651 no 223 0.011660172353955 179 1822314
SGTC_2149 5554786 194.827 µM 2.26478804106729 0.0298308089715233 no 224 0.01176284482578 199 745063 YPR165W RHO1
SGTC_1617 st002906 78 µM 2.26452638225454 0.0298453079074404 no 225 0.0117708795023773 174 5150859
SGTC_985 1493-0307 8.71 µM 2.25913799520456 0.0301451891629104 no 226 0.0119374011624716 111 3278274
SGTC_2585 alliin 100 µM 2.25738278740511 0.0302434098920818 no 227 0.0119920831592505 181 87310 A garlic compound which reacts with lipids.
SGTC_1233 0325-0408 14.2 µM 2.25564909369478 0.0303406869439811 no 228 0.0120463080145597 158 12874
SGTC_1052 3253-3998 198 µM 2.25531050646186 0.0303597152060622 no 229 0.0120569228085286 183 5450317
SGTC_172 1112-0046 2.638 µM 2.25346588769004 0.0304635546867514 no 230 0.0121148946198897 153 2802135 YIL048W NEO1
SGTC_2771 fluoxetine 41.05 µM 2.25324955933027 0.0304757517544175 no 231 0.0121217090906031 146 3386 A selective serotonin reuptake inhibitor.
SGTC_970 1315-0089 19.5 µM 2.24796926974655 0.0307747228174665 no 232 0.0122890747576432 145 6811083 YLR033W RSC58
SGTC_252 miconazole 1.30953 nM 2.24605302857558 0.0308838195252324 no 233 0.0123503057429219 176 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1800 st050079 29.0735 µM 2.24543923462632 0.030918832064101 no 234 0.0123699745300747 367 3645560
SGTC_387 norethindrone acetate 66.7 µM 2.23248719977447 0.031665346236501 no 235 0.0127913901461751 134 541197
SGTC_45 0kpi-0036 14.9 µM 2.22703431658613 0.0319840578339332 no 236 0.0129724901962397 151 2795021
SGTC_1601 4'-hydroxyflavanone 55.5 µM 2.22640397140919 0.0320210706388646 no 237 0.0129935673570556 195 165506
SGTC_2291 7917025 104.35 µM 2.22558738196646 0.0320690719727457 no 238 0.0130209160749717 219 2964612
SGTC_2498 4'-Methoxychalcone 54.63 µM 2.22384665571284 0.0321715948905089 no 239 0.0130793815699467 165 641818 YHR062C RPP1
SGTC_2316 5844804 197.44 µM 2.21755515744185 0.0325444014886168 no 240 0.0132925891430864 225 776813
SGTC_3154 9100113 49.47 µM 2.20755453057752 0.0331443234644334 no 241 0.0136376708729337 174 25237525
SGTC_2372 9071633 200 µM 2.19947251575824 0.0336357813993537 no 242 0.0139221706630215 141 21321366
SGTC_1658 st012944 20 µM 2.18865346208301 0.0343030478034614 no 243 0.0143110184429807 204 24207260
SGTC_1955 wogonin 32.4 µM 2.18237260975153 0.0346953859660033 no 244 0.0145410220590744 150 5281703 A flavanone.
SGTC_2388 9080168 200 µM 2.17835555930794 0.0349482407367263 no 245 0.0146897878821051 127 15943073
SGTC_1076 itraconazole 331 nM 2.17478849669823 0.0351740368902858 no 246 0.0148229847561114 177 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1718 roemerine 11.9335 µM 2.17454668547004 0.0351893868336528 no 247 0.0148320516458059 245 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2001 4023502 57.655 µM 2.17353257578467 0.0352538214014239 no 248 0.0148701283942196 192 108941 YCR052W RSC6
SGTC_958 1222-0007 33 µM 2.17341707740326 0.0352611660803067 no 249 0.0148744703356145 201 7312461
SGTC_1145 3546-0597 10.2 µM 2.16945901101036 0.0355136237229475 no 250 0.0150239265100638 191 875334
SGTC_1648 st011736 69.8 µM 2.16556605701288 0.0357633719555003 no 251 0.0151721812544949 150 2855514
SGTC_1155 4088-0394 48.2 µM 2.161685194122 0.0360137752254717 no 252 0.0153212248209618 176 2326248
SGTC_3115 9123671 49.47 µM 2.16145476144331 0.0360286883858215 no 253 0.0153301139390673 112 3286988
SGTC_2265 7929201 200 µM 2.15897949671318 0.0361892019524067 no 254 0.0154258788181772 185 1265108
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 2.15591122513984 0.0363889824733501 no 255 0.0155452988949812 222 6708561
SGTC_1180 1193-0155 285 µM 2.15033963671221 0.0367540656541401 no 256 0.015764179648448 176 2921347
SGTC_2815 7968870 71.43 µM 2.14242136022523 0.0372780660998431 no 257 0.0160797952787786 216 2977326 YHR190W ERG9
SGTC_2881 9058953 51.95 µM 2.14013474181005 0.0374305161991641 no 258 0.0161719395701183 214 17122249
SGTC_1187 1391-0724 117 µM 2.1373147773865 0.037619225566623 no 259 0.0162861988671006 181 6997986
SGTC_1722 st034304 3.6505 µM 2.13600124387453 0.0377073907857669 no 260 0.016339656215951 213 4036148 YLR033W RSC58
SGTC_2907 7721985 69.9 µM 2.13396853980551 0.0378441596007375 no 261 0.0164226780865704 196 3267881
SGTC_397 arbidol 50 µM 2.12292817456924 0.0385940884340996 no 262 0.0168799355427467 194 131410 A RNA synthesis inhibitor.
SGTC_1634 st006576 41 µM 2.11519060952238 0.0391268542819702 no 263 0.0172068524865058 191 3915356
SGTC_3318 9139014 38.6185 µM 2.11080545317515 0.0394314400114001 no 264 0.0173945186131326 162 16643984
SGTC_315 k915-0449 187 µM 2.10966930472796 0.0395106688490312 no 265 0.0174434250988938 269 20970215 YNL149C PGA2
SGTC_457 grayanotoxin iii 135 µM 2.10669252752021 0.0397188673847732 no 266 0.0175721201770823 295 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1104 tacrolimus 29.8 µM 2.09256214575128 0.0407193580112591 no 267 0.0181941293499488 202 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1458 k015-0034 6.33 µM 2.08814728114868 0.0410361093948224 no 268 0.0183922755682208 177 3598957
SGTC_3273 9137859 49.47 µM 2.08747819528145 0.0410842879183835 no 269 0.0184224650300682 118 2377234
SGTC_1152 3909-8331 15.9 µM 2.07684958841673 0.0418557863169553 no 270 0.0189077218788379 177 16001939
SGTC_2618 avocadyne 43.43 µM 2.07377418415384 0.0420811959062673 no 271 0.0190501439094746 180 3015189
SGTC_2652 actinonin 100 µM 2.07084798382914 0.0422965808866541 no 272 0.0191865022218132 130 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2697 mebhydrolin 72.4 µM 2.06596917001576 0.0426576717677227 no 273 0.0194156953713697 276 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2614 arthonioic acid 13.39 µM 2.05889970296863 0.0431853152295054 no 274 0.0197519237789364 190 6710684
SGTC_956 1185-0240 191 µM 2.05084711427859 0.0437927444271418 no 275 0.0201409188628677 206 1416193
SGTC_945 3381-0768 11.3 µM 2.03744856980727 0.0448186928765416 no 276 0.0208025554217575 224 1126236 YIL048W NEO1
SGTC_2358 9037157 4 µM 2.03455054221818 0.0450431255892262 no 277 0.0209480590633315 220 2388925
SGTC_3033 9090887 49.47 µM 2.02784076857986 0.0455662243981952 no 278 0.0212882509835117 233 19325384
SGTC_1472 k841-0093 193 µM 2.0245938053293 0.0458211079336187 no 279 0.0214545454378158 233 X1472
SGTC_776 4476-4378 112 µM 2.02444353336299 0.0458329318255581 no 280 0.0214622681862044 178 2892008
SGTC_1525 8-methoxypsoralen 92.5 µM 2.0084986301184 0.0471015270056408 no 281 0.0222951657371232 238 4114 Related to psoralen; DNA damaging agent.
SGTC_3041 9091929 49.47 µM 1.99761765094039 0.0479832785642181 no 282 0.0228790640720663 231 25236887
SGTC_139 0099-0334 718.624 µM 1.99253746062654 0.048399456962334 no 283 0.0231560596240159 273 97690
SGTC_2085 5307070 144.047 µM 1.98694039116567 0.048861316263169 no 284 0.023464501452101 201 2840351
SGTC_1222 0366-0074 1.18 µM 1.97870545614265 0.049547242575302 no 285 0.0239245891547132 212 286520
SGTC_1962 st076595 64.5 µM 1.97480358872999 0.0498749198078789 no 286 0.0241452208185334 241 279619
SGTC_1872 amphotericin b 148 nM 1.96982231603678 0.0502957543152284 no 287 0.0244293690267338 218 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.95045635953011 0.0519588062311758 no 288 0.0255608750080816 241 16486 A toxic proline analog.
SGTC_2804 7954240 19.48 µM 1.9485771639664 0.0521224809894864 no 289 0.0256729707281003 261 828705
SGTC_2665 lovastatin 100 µM 1.94704528325069 0.0522562079868349 no 290 0.0257646529918055 221 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2266 7929956 200 µM 1.94544655538229 0.0523960608766581 no 291 0.0258606280823404 248 2967153
SGTC_906 1165-0455 526 µM 1.94055637644816 0.0528256872776376 no 292 0.0261560548726 192 3252859
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.92147595588784 0.0545287789827636 no 293 0.0273358653940469 307 551469
SGTC_2905 7799065 20.05 µM 1.9190368582946 0.0547495849940966 no 294 0.0274898346906007 195 1296806
SGTC_827 3253-0474 693 µM 1.91516267565221 0.0551017583393678 no 295 0.0277358804100662 247 5402065
SGTC_226 1,3-diallylurea 8.28947 mM 1.91300395746475 0.0552987665159922 no 296 0.0278737729113563 214 74537 YKL182W FAS1
SGTC_2992 9074591 71.4286 µM 1.91216464282221 0.0553755137740732 no 297 0.0279275398013079 203 17741321
SGTC_2222 6885208 172.143 µM 1.90975668861453 0.0555961648973635 no 298 0.028082274118565 147 609514
SGTC_2676 harmalol 100 µM 1.90769266061576 0.0557858524629784 no 299 0.0282154754409749 235 5459187 A monoamine oxidase inhibitor
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.90074094921311 0.0564284846798964 no 300 0.0286679760403532 321 688664
SGTC_2639 lactacystin 53 µM 1.8961020553933 0.0568605505947192 no 301 0.0289732754351248 259 3870 A proteasome inhibitor.
SGTC_117 lucigenin 22.078 µM 1.88774944084028 0.0576450764420271 no 302 0.0295297977873234 348 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_3224 9130643 49.47 µM 1.88529798222879 0.0578769402543172 no 303 0.029694809214726 274 17644395
SGTC_552 k242-0005 476 µM 1.88503951099246 0.0579014296388729 no 304 0.0297122518112146 218 4088318
SGTC_814 3342-0569 96 µM 1.8800549716654 0.0583752949077499 no 305 0.0300502931894466 281 4346283
SGTC_2732 terfenadine 20 µM 1.87832769059501 0.0585402111348756 no 306 0.0301681753595992 192 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2540 epiandrosterone 100 µM 1.87605415171069 0.0587578399860612 no 307 0.0303239222215596 365 441302 A steroid.
SGTC_2991 9074669 71.4286 µM 1.87504806852165 0.0588543472382043 no 308 0.0303930554596722 319 17333109
SGTC_3167 9103034 49.47 µM 1.86408122238934 0.0599144131286837 no 309 0.0311551495316565 167 5127859
SGTC_2083 5306046 65.942 µM 1.86236632767619 0.0600815202211434 no 310 0.0312757360292414 305 539837
SGTC_619 1652-1634 108 µM 1.86122933118635 0.060192515337537 no 311 0.0313558989783822 239 5400454
SGTC_1224 0823-0416 294 µM 1.85785863185043 0.0605225109910236 no 312 0.0315945461616629 254 3598164
SGTC_462 ag-879 158 µM 1.85422716497998 0.0608796182579384 no 313 0.0318533336281241 301 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2768 sulfasalazine 50.2 µM 1.85287294967005 0.0610132085788914 no 314 0.0319502855499079 251 5384001 An antioxidant and salicylic acid derivative.
SGTC_62 0180-0423 3.232 µM 1.85267779115287 0.0610324794080744 no 315 0.0319642775440772 256 30102 YGL099W LSG1
SGTC_719 2810-4230 27.3 µM 1.85210475336465 0.0610890912304564 no 316 0.0320053910405881 191 721079
SGTC_1963 st076565 50.3 µM 1.85104414900761 0.0611939792324699 no 317 0.0320816009713571 229 4914280
SGTC_3010 9080089 71.4286 µM 1.84727973058218 0.0615673962446127 no 318 0.0323533045303057 260 17027233
SGTC_1975 st070967 30.8 µM 1.84621961370959 0.0616728765789629 no 319 0.032430162090573 311 261391
SGTC_1320 1313-0481 95.3 µM 1.84612683097002 0.0616821150591011 no 320 0.0324368959221575 263 6813365 YLR208W SEC13
SGTC_95 0471-0001 561.058 µM 1.84543363216364 0.0617511718286429 no 321 0.0324872422668869 276 4015405
SGTC_3057 9095946 49.47 µM 1.84199922213762 0.0620941999183677 no 322 0.032737631828195 225 24540043
SGTC_2516 gossypol 71.55 µM 1.83666245064232 0.0626301831863245 no 323 0.0331298708848286 277 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_481 bay k-8644 50 µM 1.83292480759657 0.063007704891807 no 324 0.0334068769781847 262 2303 A calcium channel antagonist.
SGTC_1515 3460-0031 42.1 µM 1.82927551685571 0.0633780104382491 no 325 0.0336791722349764 207 2876596
SGTC_1608 st001473 40.5 µM 1.82875752088157 0.0634307102159559 no 326 0.0337179706055482 288 7292267
SGTC_2677 mitomycin C 100 µM 1.82796539190276 0.0635113656380619 no 327 0.0337773729058371 203 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1646 st011709 75.6 µM 1.82551412505803 0.0637614619621045 no 328 0.0339617408078258 215 5757843
SGTC_299 1273-0059 1.44 µM 1.82480263303429 0.063834196894611 no 329 0.0340154091968081 244 2848077
SGTC_2830 7992007 71.43 µM 1.82473431423628 0.06384118443369 no 330 0.0340205662041146 252 1952075
SGTC_3290 9121031 71.43 µM 1.82352966723489 0.0639644915841698 no 331 0.0341116039950959 231 17014854
SGTC_1959 st077091 55.8 µM 1.82233900402434 0.0640865492683321 no 332 0.0342017817303138 312 821356 YKL052C ASK1
SGTC_1768 st044301 37.178 µM 1.81256582790861 0.0650952745178029 no 333 0.0349494061740929 282 3931349
SGTC_144 4161-2749 112.381 µM 1.80788946555368 0.0655822770404058 no 334 0.035311852822653 233 797501 YMR168C CEP3
SGTC_359 0081-0058 15.9 µM 1.80723218271461 0.065650953196629 no 335 0.0353630424984877 299 3494159
SGTC_642 0335-0876 158 µM 1.80508657793924 0.0658755246950015 no 336 0.0355305675305652 313 6812350
SGTC_536 3852-0578 10.6 µM 1.80060744375433 0.0663462552019781 no 337 0.0358823875442452 266 2869208
SGTC_1839 st053978 48 µM 1.7946517169614 0.0669761959699626 no 338 0.0363546038863749 274 3788398
SGTC_2499 avocadenofuran 51.48 µM 1.79219262207614 0.0672376414002667 no 339 0.0365510580449855 315 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1228 0124-0032 52.5 µM 1.7879491661008 0.0676906507604025 no 340 0.0368921047806096 303 X1228
SGTC_1354 1498-1681 81 µM 1.78756113427967 0.0677321924049115 no 341 0.0369234203247295 301 5754243
SGTC_3175 9106517 49.47 µM 1.78701729233507 0.067790447801584 no 342 0.0369673468689576 250 41468073
SGTC_1625 st003711 30.1 µM 1.7846264688451 0.0680470077585158 no 343 0.0371609625629633 283 24207034 YER133W GLC7
SGTC_2855 9016525 58.44 µM 1.77587100509741 0.0689929619581948 no 344 0.0378770904940383 301 43811474
SGTC_2962 9082311 13.18 µM 1.77357761452122 0.0692424109796933 no 345 0.0380665215907154 261 16459453
SGTC_1419 3993-2473 62.6 µM 1.7652358099501 0.0701556009164559 no 346 0.038762071268005 280 704026
SGTC_792 4534-1957 155 µM 1.76301228731608 0.0704005701972661 no 347 0.0389492086596514 276 1717904
SGTC_781 4335-2806 94.4 µM 1.76144610113469 0.0705735139945353 no 348 0.039081464016416 328 845254
SGTC_3266 9136860 49.47 µM 1.75971201076867 0.0707653790982651 no 349 0.0392283241547438 313 4871271 YPR165W RHO1
SGTC_3307 9126885 69.2785 µM 1.75499067609126 0.071289793264843 no 350 0.039630451309307 337 24824909
SGTC_1363 1636-0063 10.4 µM 1.7526328496421 0.0715527992648426 no 351 0.0398325244218882 321 6072185
SGTC_1917 st066507 28.5 µM 1.75092950176208 0.071743263574203 no 352 0.0399790271437777 371 3156428
SGTC_801 0866-0028 10.1 µM 1.73293804642433 0.0737788393413388 no 353 0.0415533404931924 354 6849771
SGTC_1762 st045503 25.4615 µM 1.73218917779132 0.0738645145124576 no 354 0.0416199426363693 324 4645554
SGTC_3026 9090633 49.47 µM 1.72569282849297 0.0746109302866392 no 355 0.0422013444573946 297 25236842
SGTC_134 0269-0018 6.916 µM 1.7177257997329 0.0755341665148951 no 356 0.0429233205891902 418 4378915
SGTC_2314 7727897 200 µM 1.71333240248719 0.0760469929299511 no 357 0.0433257022519094 307 900724
SGTC_76 0433-0009 400.328 µM 1.71266046145648 0.076125659490144 no 358 0.0433875115433424 260 2841569
SGTC_1486 3970-0793 4.53 µM 1.70936961019042 0.0765118261456605 no 359 0.0436912532417559 280 2844330
SGTC_2 0422-0095 29 µM 1.70675120141636 0.0768201477760087 no 360 0.0439341530177338 221 6790840
SGTC_2132 5317594 122.667 µM 1.69887093710802 0.077753760738056 no 361 0.0446717520328142 279 794577
SGTC_2105 5350118 200 µM 1.69620283457828 0.0780718077320827 no 362 0.0449237369217705 314 2133313
SGTC_3085 9117376 49.47 µM 1.69485792744579 0.0782324989496801 no 363 0.0450511876971758 319 16480349
SGTC_1100 amiodarone 5.07 µM 1.69420096135098 0.0783110852321466 no 364 0.0451135511176147 351 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1441 4106-0040 13 µM 1.69343915851166 0.0784022870232982 no 365 0.0451859532748804 307 2904180
SGTC_2537 larixol 68.93 µM 1.68958670931591 0.0788647296941446 no 366 0.0455535251928685 342 6708759
SGTC_248 streptozotocin 5.23457 mM 1.68872309883394 0.0789686792739121 no 367 0.0456362534491293 345 5300 DNA alkylating agent.
SGTC_1292 0kpi-0043 232 µM 1.68736105707276 0.0791328340357325 no 368 0.0457669735926694 319 3333905
SGTC_3202 9113761 49.47 µM 1.68239735256004 0.0797332522348119 no 369 0.0462459072118001 420 4798415
SGTC_2621 lithochol-11-enic acid 100 µM 1.68221149684258 0.0797558004085912 no 370 0.0462639177679872 379 6708711
SGTC_998 3996-0085 177 µM 1.67795049118884 0.0802740730722534 no 371 0.0466783822378289 372 715391
SGTC_2729 fluphenazine 10.66 µM 1.67716052162209 0.0803704373346531 no 372 0.0467555482958225 356 3372 An atypical antipsychotic.
SGTC_1982 st072467 71.9 µM 1.67422194442377 0.0807296664317206 no 373 0.0470434941223547 409 3163533
SGTC_459 nigericin 15.3 µM 1.67387453034199 0.0807722164081717 no 374 0.0470776303806694 383 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_3227 9130768 49.47 µM 1.66657186101391 0.0816705436503046 no 375 0.0477997840130104 279 17720899
SGTC_2365 9042475 200 µM 1.66603080388601 0.0817373995211868 no 376 0.0478536396077628 356 6464479
SGTC_395 anisomycin 6.25 µM 1.65320312583173 0.0833345635666576 no 377 0.0491447652697784 273 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1403 3909-7815 62.9 µM 1.65063816665735 0.0836567204003597 no 378 0.0494062403206051 282 6615483
SGTC_1742 st038235 28.8875 µM 1.63968500021083 0.0850429641380575 no 379 0.05053533965686 407 564103 YBR002C RER2
SGTC_1829 berberine 14.4 µM 1.63915748612149 0.0851101588181882 no 380 0.0505902326688763 333 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_603 3794-0023 45.9 µM 1.63762355317903 0.0853057770681033 no 381 0.0507501233200285 305 3802260
SGTC_542 3381-0244 89.3 µM 1.63746847544179 0.0853255724379186 no 382 0.0507663103372645 402 1112843
SGTC_1901 st060216 58.6 µM 1.63330880887308 0.0858578306381398 no 383 0.0512020325296603 345 688792
SGTC_1146 3579-1023 7 µM 1.63324771999968 0.0858656658564053 no 384 0.0512084536477985 403 X1146
SGTC_1818 st052136 56.3 µM 1.63077805979304 0.0861828711388959 no 385 0.0514685792774136 380 674169
SGTC_1016 4226-1401 38 µM 1.62583800373222 0.086820005139347 no 386 0.0519920607201842 377 2901613
SGTC_1367 1812-0510 76.9 µM 1.6218604045293 0.0873355606728893 no 387 0.0524166206307675 352 1142582 YDR527W RBA50
SGTC_3073 9114972 49.47 µM 1.6216651813292 0.0873609231920961 no 388 0.0524375289621652 318 41905075
SGTC_947 3447-0010 211 µM 1.61857602126798 0.0877629851052885 no 389 0.0527692589139077 336 748350
SGTC_1892 st058411 7.36 µM 1.61700697039452 0.0879677288587947 no 390 0.052938388152326 422 3934738
SGTC_3341 9147222 25.867 µM 1.6169069806518 0.0879807884745627 no 391 0.0529491806814288 336 1939759
SGTC_1485 3909-9022 254 µM 1.61581249407795 0.0881238334141384 no 392 0.0530674297081873 354 714516
SGTC_1231 0242-0792 125 µM 1.61252769389331 0.0885541844113342 no 393 0.0534235792646052 350 3707635
SGTC_2343 7990716 14.84 µM 1.6122492177893 0.0885907402195127 no 394 0.0534538595077645 367 6456862
SGTC_1961 st076550 68.7 µM 1.61100454920347 0.0887542663899206 no 395 0.0535893654564976 314 1579337
SGTC_1816 st051957 91.6 µM 1.61061082348731 0.0888060413542041 no 396 0.0536322866313684 338 674121
SGTC_255 tunicamycin 200.472 nM 1.60988530467249 0.0889015060360589 no 397 0.0537114488457137 393 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1430 4049-0248 69.1 µM 1.60968167897281 0.0889283130884759 no 398 0.0537336833099302 401 22774488
SGTC_1220 1838-0075 193 µM 1.60963869194279 0.0889339730429834 no 399 0.0537383781166911 371 5529645
SGTC_1063 disulfiram 1.84 µM 1.60633602134439 0.0893696265428229 no 400 0.0541000499309892 378 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2179 6298986 200 µM 1.60271728345811 0.0898487928088986 no 401 0.0544985429701979 318 738374
SGTC_2067 5224629 34.075 µM 1.59670061093154 0.0906496983036223 no 402 0.055166229708948 388 2835000
SGTC_513 4245-1575 41.7 µM 1.59411584769823 0.0909953899747038 no 403 0.0554550450074051 534 719745
SGTC_389 tpck 16.7 µM 1.58814576030017 0.0917975781262521 no 404 0.0561266913792134 352 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2833 9001315 45.46 µM 1.58177497173344 0.09265937254893 no 405 0.056850475286872 415 2989378
SGTC_1449 4112-4002 201 µM 1.58087126629184 0.0927821023574729 no 406 0.0569537377138616 370 2059539
SGTC_2073 5212005 126 µM 1.57853512829472 0.0930999239458937 no 407 0.0572213622804414 271 691789
SGTC_1557 sumaresinolic acid 42.3 µM 1.57629807060587 0.0934050195548067 no 408 0.0574785630444024 361 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1604 st002052 72.4 µM 1.575085102347 0.0935707557279621 no 409 0.0576184011424631 393 6254834 YHR062C RPP1
SGTC_2682 pyrogallin 40.03 µM 1.57454300850084 0.0936448959047189 no 410 0.0576809833469729 421 822798 An ATP competetive kinase inhibitor.
SGTC_1888 azatryptophan 97.5 µM 1.56678756353281 0.0947103329643157 no 411 0.0585821776392413 323 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_341 1486-1430 230 µM 1.56615869086579 0.094797117011836 no 412 0.058655735422245 386 2054753 YPL210C SRP72
SGTC_1906 st060206 94.7 µM 1.56561341076932 0.0948724127558342 no 413 0.0587195742457287 404 5133468
SGTC_3270 9137563 49.47 µM 1.56363146775063 0.0951464632155845 no 414 0.0589520702363311 325 17015724
SGTC_2735 sertaconazole 140 nM 1.56060953972027 0.0955654376243929 no 415 0.059307953265824 291 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1165 k072-0275 30.3 µM 1.55856913961264 0.0958490951992128 no 416 0.059549195960797 368 6153523 YGL055W OLE1
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.55752344210678 0.0959947084566313 no 417 0.0596731296701995 285 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2600 tangeritin 87.95 µM 1.5519767766812 0.0967698015253699 no 418 0.0603338902295269 372 68077 A bioactive flavone.
SGTC_3134 9127454 49.47 µM 1.54966359831809 0.0970944003918891 no 419 0.0606111397580412 352 24262820
SGTC_107 0358-0022 2.6945 µM 1.54915189771517 0.097166313063729 no 420 0.0606726048246839 260 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2650 prasterone 100 µM 1.54731657260965 0.0974245649563249 no 421 0.0608934637064293 269 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_22 0964-0034 14.468 µM 1.54507279357614 0.097740974723702 no 422 0.0611643284381698 442 138402
SGTC_815 1582-0027 36.9 µM 1.54499497434022 0.0977519620180624 no 423 0.0611737394950771 404 3128206
SGTC_778 3456-2434 196 µM 1.54497795310037 0.0977543653668189 no 424 0.061175798106826 505 5539063
SGTC_73 0327-0325 16.231 µM 1.54278187393437 0.0980648087029441 no 425 0.0614418544235045 462 53298
SGTC_1272 0839-0021 27 µM 1.54196379729697 0.0981806385733351 no 426 0.061541195638889 414 5027250
SGTC_3113 9123498 49.47 µM 1.5391005644546 0.0985868273339314 no 427 0.0618898736407746 369 8897275
SGTC_411 enrofloxacin 100 µM 1.53534873837326 0.0991209354569502 no 428 0.0623490941042128 369 71188 A bacterial gyrase inhibitor.
SGTC_2588 indole-3-carbinol 100 µM 1.53416160213796 0.0992903755414284 no 429 0.0624949507105753 455 3712 Induces cell cycle arrest.
SGTC_1479 0549-0158 134 µM 1.53230847016023 0.099555296422903 no 430 0.0627231659621878 430 5440202
SGTC_1806 st050005 60.3 µM 1.52869973349892 0.100072677577471 no 431 0.063169449206395 397 5194765
SGTC_3309 9129340 25.759 µM 1.52603980763357 0.10045528351362 no 432 0.0634999754899989 422 17158987
SGTC_1232 0279-0259 161 µM 1.52527424276039 0.100565600549855 no 433 0.063595354714061 417 1560000
SGTC_2081 5214970 32.255 µM 1.5245440278865 0.100670906017398 no 434 0.0636864336355145 387 2063512
SGTC_1376 2910-0861 41.3 µM 1.52331360947811 0.100848528544211 no 435 0.0638401319352023 425 1112859
SGTC_1249 0481-0015 10.2 µM 1.52074718471443 0.10121975140099 no 436 0.0641616464308109 359 4227577
SGTC_2749 bexarotene 57.39 µM 1.519822828926 0.10135369929202 no 437 0.064277754955619 428 82146 An retinoic acid receptor inhibitor.
SGTC_1410 3909-8106 77.9 µM 1.51969507349377 0.101372222414199 no 438 0.0642938151784491 369 1039210
SGTC_1891 st059073 26.2 µM 1.5191689288713 0.101448533546848 no 439 0.064359990049625 425 688754
SGTC_3218 9131285 49.47 µM 1.51905131600473 0.101465597640172 no 440 0.0643747898267954 488 17156417
SGTC_1933 st074711 15.9 µM 1.5187322025114 0.10151190737814 no 441 0.0644149586921608 440 17250958
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 1.51822630408392 0.101585354881415 no 442 0.0644786792839483 423 688801
SGTC_2268 7933382 153.85 µM 1.51772196955293 0.101658613846355 no 443 0.0645422516284207 486 935025 YOR257W CDC31
SGTC_1450 4112-4260 37.6 µM 1.51723936662882 0.101728752116555 no 444 0.0646031302397103 421 1633175
SGTC_1499 4480-0877 67.3 µM 1.51118824790292 0.102611172946954 no 445 0.0653702478744066 348 2861909
SGTC_463 ikarugamyin 104 µM 1.50963144543823 0.102839095125238 no 446 0.0655687464527965 296 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1977 st070720 65.3 µM 1.50847020036851 0.103009345476984 no 447 0.0657171139655418 370 682188
SGTC_1390 3413-2614 145 µM 1.50754954211579 0.103144468784757 no 448 0.0658349275440675 432 3421432
SGTC_2121 5257820 149.641 µM 1.50719500278466 0.103196538181123 no 449 0.0658803403973802 442 791256
SGTC_229 benomyl 22.8748 µM 1.50672845381067 0.103265086948677 no 450 0.0659401375263691 442 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_790 1575-0012 79.1 µM 1.50469729738344 0.103563904504846 no 451 0.0662009591217959 433 378741 YLR208W SEC13
SGTC_273 hydroxyurea 18.1 mM 1.50345305632498 0.103747263117722 no 452 0.066361126840934 488 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1029 k015-0030 64.7 µM 1.49979780463349 0.104287284247469 no 453 0.0668333930981041 414 2208316
SGTC_1518 st038567 90.8 µM 1.49492808188106 0.105009890410896 no 454 0.0674666062428021 359 77966
SGTC_2651 TUB2.036 5 µM 1.49383411936234 0.105172718169746 no 455 0.0676094906286903 632 15992207 YFL037W TUB2
SGTC_1469 k284-2957 126 µM 1.49379500450367 0.105178543491558 no 456 0.0676146038157778 384 23884841
SGTC_1253 0550-0034 176 µM 1.49124265519525 0.105559166189156 no 457 0.0679488992323223 410 5969915
SGTC_623 k072-0108 16.9 µM 1.48332711608538 0.106745914596737 no 458 0.0689937606572014 439 5382803
SGTC_679 0422-0091 41.4 µM 1.47982526442061 0.10727399545444 no 459 0.0694599422434664 470 627384 YHR062C RPP1
SGTC_2003 4023581 200 µM 1.47833829161308 0.107498800421859 no 460 0.0696586266725768 440 16641307
SGTC_3143 9086658 49.47 µM 1.47323864283737 0.108272358948872 no 461 0.0703433493405836 497 25236626
SGTC_1748 st037455 53.6035 µM 1.46976121535143 0.10880213730193 no 462 0.0708132184214268 450 580690
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.46832865058313 0.109020926578042 no 463 0.071007486046544 444 688669
SGTC_1764 st044502 93.5 µM 1.46575972259539 0.109414059209061 no 464 0.0713568787192485 454 8407
SGTC_900 1112-0045 141 µM 1.46179959977861 0.110022084542647 no 465 0.0718980669141846 329 56211 YIL048W NEO1
SGTC_3147 9097027 49.47 µM 1.46112629271234 0.110125702746281 no 466 0.0719903929340463 450 25236841
SGTC_1964 st076914 61 µM 1.45844219036958 0.110539466884825 no 467 0.0723593493113708 412 24208661
SGTC_2653 dihydrofissinolide 100 µM 1.45299700014762 0.111382283668963 no 468 0.0731122934570199 391 6857746
SGTC_3258 9138477 49.47 µM 1.45258869096775 0.111445667410999 no 469 0.0731689939343768 417 4970355
SGTC_2349 9023730 187.07 µM 1.44900181709681 0.112003584244793 no 470 0.0736685375628543 449 4126287
SGTC_3159 9100096 49.47 µM 1.44204215534746 0.113091808458969 no 471 0.0746452408541678 443 25236875
SGTC_1277 0873-0036 22 µM 1.44047188821302 0.113338377748344 no 472 0.0748669689215283 498 5965735
SGTC_681 1642-0006 26.6 µM 1.43912681496478 0.113549890949832 no 473 0.0750572979325346 393 4446530
SGTC_1708 st033234 31.827 µM 1.43706760019081 0.113874248142712 no 474 0.0753493931620923 489 674664
SGTC_3348 9149464 3.537 µM 1.43668220270801 0.113935027299196 no 475 0.075404157102562 452 1951442
SGTC_756 0508-1999 28.3 µM 1.43620767388428 0.114009894671204 no 476 0.0754716280305125 442 6753853
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.43444935906152 0.114287613080314 no 477 0.0757220353251021 370 4620898
SGTC_628 1636-0253 16 µM 1.43381047000039 0.114388642132322 no 478 0.0758131781704554 488 4456143
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.43356718172102 0.114427130599941 no 479 0.0758479072276537 432 229346 A bile salt which induces apoptosis.
SGTC_2452 5863136 48.41 µM 1.43355628212907 0.114428855142861 no 480 0.0758494634124764 454 2184096
SGTC_140 0062-0056 502.533 µM 1.4323472218424 0.11462026859007 no 481 0.0760222374991032 501 3758964
SGTC_709 3807-1509 243 µM 1.42456212538042 0.115858231302178 no 482 0.0771419074027872 414 1886677 YPL242C IQG1
SGTC_148 3253-0744 288.01 µM 1.42008448454036 0.116574538306886 no 483 0.0777915433455909 438 6893655
SGTC_410 α-linolenic acid 100 µM 1.41999770453866 0.116588451824029 no 484 0.0778041746639243 507 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1713 st033146 12.748 µM 1.4183448151532 0.116853685951665 no 485 0.0780450593235047 475 674619
SGTC_1473 k844-0725 134 µM 1.41732709863922 0.117017208416305 no 486 0.0781936579359752 518 54682906
SGTC_1305 1181-0477 144 µM 1.4149618118833 0.117397879067961 no 487 0.0785398465263753 453 6252086
SGTC_794 k038-0031 316 µM 1.41456724618404 0.117461465953326 no 488 0.0785977089277255 569 6624242
SGTC_258 haloperidol 50.781 µM 1.41228853999519 0.117829171711973 no 489 0.0789325096774862 485 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2352 9027995 87.8 µM 1.41109994270131 0.118021293833017 no 490 0.0791075734559538 406 2997347
SGTC_2809 7964133 12.99 µM 1.40810828499215 0.118505838909678 no 491 0.0795495040693559 494 1253665
SGTC_1408 3909-7976 48.8 µM 1.40698635272599 0.118687915129285 no 492 0.0797157178020052 520 24152374
SGTC_3030 9087619 49.47 µM 1.40331053193203 0.119285841247234 no 493 0.0802621294768679 458 25236973
SGTC_1149 3909-7961 23.3 µM 1.40126375869711 0.11961969884586 no 494 0.0805676071878542 464 735261
SGTC_878 0828-0289 13.7 µM 1.39826619264615 0.120109832696456 no 495 0.0810165730052915 554 745350 YLR208W SEC13
SGTC_233 rapamycin 362 pM 1.39688277987563 0.120336512018385 no 496 0.0812244118652807 475 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1429 4049-0205 9.46 µM 1.39531013143551 0.120594564391515 no 497 0.0814611690998641 495 22774478
SGTC_1889 st059080 5.18 µM 1.39218232031995 0.121108957439135 no 498 0.081933597544111 516 176925 Isolated from Daphnopsis sellowiana.
SGTC_2280 7785178 200 µM 1.39158995193318 0.12120655064034 no 499 0.0820233016632083 445 2954328
SGTC_3192 9110362 49.47 µM 1.39077060581817 0.121341629760392 no 500 0.0821474996314038 491 16649480
SGTC_2978 9011784 42.97 µM 1.39073012281059 0.121348306617117 no 501 0.0821536397895531 562 2994934
SGTC_3229 9132204 49.47 µM 1.38976592910968 0.121507407300116 no 502 0.0822999836300922 415 17682924
SGTC_3112 9123419 49.47 µM 1.38820327224695 0.121765571110436 no 503 0.0825375780779488 522 17015854
SGTC_2315 7733312 200 µM 1.3860383908611 0.12212386381496 no 504 0.0828675905336786 447 726316
SGTC_2645 abamectin 100 µM 1.38523418563915 0.122257149962431 no 505 0.0829904353641066 490 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2108 5365811 200 µM 1.38470785050248 0.122344438166993 no 506 0.0830709088102749 494 780283
SGTC_748 act1.228 77.9 µM 1.38306914843054 0.122616483029992 no 507 0.0833218321988258 552 4421505 YNR035C ARC35
SGTC_195 4234-0266 16.654 µM 1.37928025195978 0.123247110980422 no 508 0.0839041814295097 555 2303354
SGTC_447 ml7 120 µM 1.37912855307049 0.123272407137982 no 509 0.0839275608610139 489 4216 Selective myosin light chain kinase inhibitor.
SGTC_942 3253-1115 227 µM 1.37711657822851 0.123608252955217 no 510 0.0842381039742213 497 46497897
SGTC_698 k064-0052 127 µM 1.37498230159585 0.123965213604839 no 511 0.0845684658544401 424 5088751
SGTC_1957 st077035 62.4 µM 1.372072256658 0.124453084024568 no 512 0.0850204725482227 488 705593
SGTC_1680 diphenhydramine 100 µM 1.37084019665767 0.124660043463389 no 513 0.0852123886441543 487 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1173 0443-0020 122 µM 1.37002097067509 0.124797788795854 no 514 0.0853401777724005 506 5331295
SGTC_416 estradiol valerate 100 µM 1.36888408646536 0.124989121603813 no 515 0.0855177554351954 480 13791 A steroid.
SGTC_2156 5649887 115 µM 1.35809724200318 0.126814700112922 no 516 0.0872164151251148 585 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2758 dehydroepiandrosterone 69.35 µM 1.35715943082875 0.126974289067685 no 517 0.0873652790704033 550 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_92 0063-0024 660.874 µM 1.35590896875876 0.127187299746374 no 518 0.0875640667705686 564 3594437
SGTC_1746 st038117 42 µM 1.35581697177156 0.127202980838681 no 519 0.0875787049785988 516 2898218
SGTC_873 0591-4978 488 µM 1.35550349566367 0.127256423642942 no 520 0.0876285978074418 559 3305145
SGTC_989 1501-0895 10.3 µM 1.35361038256406 0.127579502001939 no 521 0.0879303563701673 487 2830112
SGTC_2868 9035608 32.47 µM 1.35211364914603 0.127835337617328 no 522 0.0881694807940336 529 6462614
SGTC_2704 st078022 71.1 µM 1.35133607797903 0.127968387950008 no 523 0.0882939000062268 493 54697681
SGTC_2342 7990637 118.86 µM 1.34632931032781 0.128827400954053 no 524 0.0890981686204302 541 2033102 YER133W GLC7
SGTC_635 k038-0028 24.7 µM 1.34533626860909 0.128998251744183 no 525 0.0892583330908669 525 4035102
SGTC_296 1222-0039 74.9 µM 1.34045997635744 0.129839487638267 no 526 0.0900479240235542 483 5984176
SGTC_2883 9059145 45.46 µM 1.33643060364767 0.130537477088245 no 527 0.0907042844658139 478 16476510
SGTC_1568 digitonin 820 nM 1.33518512422322 0.130753749692035 no 528 0.0909078821697875 566 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2518 prenyletin 46.28 µM 1.33477137962482 0.130825649590008 no 529 0.0909755916956641 415 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2274 7947094 46.08 µM 1.33297089283365 0.131138853575871 no 530 0.0912706779835475 530 2971028
SGTC_1417 3966-0327 90.4 µM 1.33187303222885 0.131330086103604 no 531 0.0914509570506145 571 651118
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.33053771167917 0.131562940378631 no 532 0.0916705848531849 487 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1596 piperlongumine 63 µM 1.32862372601239 0.131897199445331 no 533 0.0919860701958399 569 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_703 3875-0075 71.8 µM 1.32678870147881 0.132218218330709 no 534 0.0922892944998826 544 2850814
SGTC_911 3456-4043 236 µM 1.32396915984431 0.132712517364694 no 535 0.0927566436729718 549 914281
SGTC_1136 pergolide 1.05886 µM 1.32096437616746 0.13324069088005 no 536 0.0932566213387277 615 47811 A dopamine receptor agonist.
SGTC_2146 5545642 200 µM 1.3198156927509 0.133442985281177 no 537 0.0934482804432064 530 825326
SGTC_1864 st057645 30.4 µM 1.31823089369323 0.133722430560064 no 538 0.0937131833106821 481 688666
SGTC_890 0929-0006 47.2 µM 1.31765468728425 0.133824131842304 no 539 0.0938096348619538 511 1378169
SGTC_932 2857-0803 154 µM 1.31187598985786 0.134847020855659 no 540 0.0947809899652892 583 674898
SGTC_2775 cyproheptadine 69.59 µM 1.31091697165455 0.135017294545732 no 541 0.094942908151741 545 2913 A selective serotonin reuptake inhibitor.
SGTC_1692 fluoroquinolonic acid 71 µM 1.3062918234427 0.1358405597412 no 542 0.0957266683174133 510 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2350 9023895 38.85 µM 1.30011598166315 0.136945194363194 no 543 0.0967806104696464 546 2997209
SGTC_3184 9108758 49.47 µM 1.29961008982755 0.137035951355734 no 544 0.0968673198786078 518 902885
SGTC_1505 k297-0037 20.6 µM 1.29849497568207 0.137236147935792 no 545 0.0970586508594399 562 4089396
SGTC_1780 st038448 24.544 µM 1.29510032149401 0.137846819881504 no 546 0.0976428120167355 547 728868 YDL195W SEC31
SGTC_3355 9151058 44.0485 µM 1.29176265000088 0.138449046031756 no 547 0.098219676837777 532 17015728
SGTC_484 loperamide 105 µM 1.28998229446649 0.138771013172541 no 548 0.098528402805252 443 3955 An opioid-receptor agonist.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.28987323558998 0.138790752410422 no 549 0.0985473374355331 656 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2031 5180455 200 µM 1.28934362336741 0.138886637379432 no 550 0.0986393257550377 499 29949
SGTC_1616 st002734 56.1 µM 1.28882682304345 0.138980246260027 no 551 0.0987291493505587 577 4026101
SGTC_3322 9139058 2.11 µM 1.28313873496678 0.140013376997858 no 552 0.0997217376250641 554 4908926 YPR165W RHO1
SGTC_170 4197-0004 226 µM 1.2810554818633 0.140393061807167 no 553 0.100087089535946 491 218692
SGTC_592 k241-0073 46.5 µM 1.28058829068829 0.14047830595887 no 554 0.100169157494154 595 4230158
SGTC_1734 st037168 69.4 µM 1.28037078513746 0.14051800421662 no 555 0.100207381812378 545 708907
SGTC_2933 9026794 32.47 µM 1.2789279875801 0.140781530757402 no 556 0.100461207941633 580 17586027
SGTC_599 1935-0052 86.5 µM 1.27719009635008 0.141099401036612 no 557 0.10076757128972 586 9557311
SGTC_837 0091-0265 12.5 µM 1.27705348836823 0.141124408036423 no 558 0.100791682015841 594 759367
SGTC_2478 5763493 32.33 µM 1.27420176906609 0.141647120437201 no 559 0.101295959212895 581 1365576 YLR208W SEC13
SGTC_2398 5228213 48.84 µM 1.27339677798791 0.141794910181043 no 560 0.101438640072238 662 80771 YMR134W ERG29
SGTC_1546 5-methoxyflavanone 78.7 µM 1.26820596584005 0.142750407975786 no 561 0.10236220355695 603 147795
SGTC_2217 6934799 96.0675 µM 1.26741837959247 0.142895762195014 no 562 0.102502865650607 561 675606
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.26689677034213 0.142992083653107 no 563 0.102596101850651 535 688803
SGTC_2666 tannic acid 100 µM 1.26508985888566 0.143326090876491 no 564 0.102919558888699 619 16134267 A thiamine antagonist.
SGTC_579 4491-1009 110 µM 1.26503381825719 0.143336458392072 no 565 0.102929602609822 718 1271041
SGTC_949 1165-0505 146 µM 1.26205124914762 0.143888964388612 no 566 0.103465172902116 608 6244267
SGTC_2455 5377712 9.75 µM 1.26120071481457 0.144046784522701 no 567 0.103618270590608 521 2243908
SGTC_860 0443-0016 25.1 µM 1.25802035943414 0.144637946547094 no 568 0.104192196658125 575 5337942
SGTC_448 monastrol 171 µM 1.25800900951367 0.144640059183978 no 569 0.10419424897991 571 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1952 st077036 64.1 µM 1.25708984388666 0.144811218658925 no 570 0.104360552164941 585 2937007
SGTC_1219 1469-0211 33.1 µM 1.25275773097059 0.145619744885214 no 571 0.105146944430493 553 6822282
SGTC_468 gf-109203x 121 µM 1.24991137286769 0.146152625658586 no 572 0.105665962228191 422 2396 A protein kinase C inhibitor.
SGTC_2689 tacrolimus 100 µM 1.24895084813481 0.146332745453551 no 573 0.105841525968621 559 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1884 5633444 25 µM 1.24584053697631 0.146917020527445 no 574 0.106411472034529 610 5724239
SGTC_3110 9122132 49.47 µM 1.24575552193666 0.146933012626061 no 575 0.106427081590357 597 918317
SGTC_2766 oltipraz 83.91 µM 1.24183183282782 0.147672364548187 no 576 0.107149307548371 570 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2326 6164455 177.58 µM 1.24133640226958 0.147765896803537 no 577 0.107240751214411 544 2888790
SGTC_2414 st077232 92.9 µM 1.24125201834651 0.1477818315837 no 578 0.107256331910335 568 729801
SGTC_2630 antimycin a 100 µM 1.23856243927644 0.148290325594667 no 579 0.10775379265165 622 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_471 1-acyl-paf 4 µM 1.23840513814412 0.148320101260393 no 580 0.107782938207069 577 16759367
SGTC_743 1275-0778 158 µM 1.23707616772166 0.148571822827693 no 581 0.108029403293676 626 2849257 YMR203W TOM40
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.23644020010094 0.148692383057585 no 582 0.108147490539684 602 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1193 1488-0126 41.5 µM 1.23506609855561 0.14895309439267 no 583 0.10840295261366 597 1384710
SGTC_2317 5986382 200 µM 1.2300985461771 0.149898145607814 no 584 0.109330102209259 604 877883
SGTC_25 0118-0223 35.662 µM 1.2294879836018 0.15001457733249 no 585 0.109444450220024 572 5333628
SGTC_2605 digitonin 300 nM 1.22678660819984 0.150530441732874 no 586 0.109951402736322 686 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2719 novobiocin 32.65 µM 1.22612553184082 0.150656863011798 no 587 0.110075719590711 514 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1842 st055362 61.2 µM 1.22583307403486 0.150712813883675 no 588 0.110130749081962 653 676032
SGTC_677 0929-0063 136 µM 1.21927177151858 0.151971711121832 no 589 0.111370529495893 535 1539583
SGTC_829 1635-0120 117 µM 1.2190042659445 0.15202318437286 no 590 0.111421286677513 637 285054
SGTC_2528 xanthyletin 44.79 µM 1.21855470034503 0.152109715577025 no 591 0.111506625675702 577 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2753 fluvastatin 17.09 µM 1.20896817212541 0.153962689924913 no 592 0.113337536697765 630 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2376 9072922 81.32 µM 1.20842984992856 0.15406718296494 no 593 0.113440981905903 628 17087968
SGTC_1454 4239-0054 42.6 µM 1.20533148525168 0.154669514560373 no 594 0.114037679775498 661 1340767
SGTC_61 0978-8327 98.565 µM 1.19962643128917 0.155782659739661 no 595 0.115142228316287 647 6150059 YHR072W ERG7
SGTC_548 1436-0017 110 µM 1.1955544108814 0.15658039733958 no 596 0.115935245529944 707 9677137
SGTC_3046 9092212 49.47 µM 1.19376965953061 0.156930888964294 no 597 0.116284041528364 607 25236637
SGTC_2321 7390090 138.78 µM 1.19353927170432 0.156976170389186 no 598 0.116329120688849 556 649046
SGTC_2386 9075165 157.42 µM 1.19308593146366 0.157065296944631 no 599 0.116417860348854 607 16452277
SGTC_1867 st057372 64 µM 1.18749293796008 0.158167615607763 no 600 0.117516620265268 619 688837
SGTC_2529 gangaleoidin 93.61 µM 1.18578950888379 0.158504349354309 no 601 0.117852717807366 626 4565183
SGTC_2224 6650123 117.647 µM 1.18324890511719 0.159007448700368 no 602 0.118355258056486 592 2908370
SGTC_3289 9119912 71.43 µM 1.18279922565271 0.159096604685512 no 603 0.118444363776343 622 17014829
SGTC_3294 9122953 26.2835 µM 1.18223730327611 0.159208060604944 no 604 0.118555777495213 644 16459826
SGTC_7 0192-1582 4.227 µM 1.18138556867272 0.159377097548142 no 605 0.118724794160906 743 252616
SGTC_2700 st077718 96.8 µM 1.18060826985719 0.15953146433348 no 606 0.118879188421948 584 904970
SGTC_919 tnp00227 403.569 nM 1.17749559875997 0.160150602037594 no 607 0.119498876593656 683 1269246 A methoxyflavone. YNL221C POP1
SGTC_560 2332-1943 155 µM 1.17137399483014 0.161372819411182 no 608 0.120724240241464 634 21177716
SGTC_2782 7736369 71.43 µM 1.16978718684842 0.161690625978923 no 609 0.121043310640323 676 2950836 YOL077C BRX1
SGTC_1474 0330-0125 5.35 µM 1.16710854446327 0.162228030485261 no 610 0.121583268846756 653 X1474
SGTC_318 1488-0629 67.2 µM 1.16675457973915 0.162299131796284 no 611 0.121654747159981 605 3662576
SGTC_133 0724-0033 378.92 µM 1.16662477672321 0.1623252105638 no 612 0.121680966494667 602 280309
SGTC_396 dithiazanine 1.25 µM 1.16654735639669 0.162340766406195 no 613 0.12169660676945 618 10578 An antihelmenthic.
SGTC_2159 5658611 73.75 µM 1.16552899376533 0.162545473389909 no 614 0.121902465533563 638 793844
SGTC_1001 4048-4355 44.4 µM 1.16004247406115 0.163651239161192 no 615 0.123015756760754 642 21824233
SGTC_2168 5727979 200 µM 1.1560119053935 0.164466673592073 no 616 0.123838143660391 595 695210
SGTC_578 3460-0051 92 µM 1.15376974626079 0.164921428477757 no 617 0.12429729033248 738 2876744
SGTC_544 k015-0020 52.4 µM 1.15223413947849 0.16523334972946 no 618 0.124612436211257 644 3008304
SGTC_2233 sulbentine 40.3845 µM 1.15206092130922 0.165268558744624 no 619 0.124648020043897 723 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.15087916820499 0.165508896130846 no 620 0.124890974535937 718 1377
SGTC_294 k038-0071 157 µM 1.14980672058491 0.165727199239289 no 621 0.125111743302354 674 24152826
SGTC_1893 st059353 36.1 µM 1.14676465814823 0.166347441673583 no 622 0.125739449723501 652 3112488
SGTC_3008 9078912 71.4286 µM 1.14626061948972 0.166450354078477 no 623 0.125843666052278 649 16648731
SGTC_2027 5150920 200 µM 1.14542600699524 0.166620851963356 no 624 0.12601636511627 665 786715
SGTC_1198 1612-1005 86.7 µM 1.1444382746304 0.166822775345985 no 625 0.126220961351184 689 6998509
SGTC_1192 1488-0095 21.4 µM 1.14169766292632 0.167383868393623 no 626 0.126789856301934 639 915875
SGTC_3193 9111931 49.47 µM 1.14025803805454 0.167679093411788 no 627 0.127089407131567 669 17087244
SGTC_1487 3970-0795 2.82 µM 1.13991708314406 0.167749062392707 no 628 0.127160423606152 704 3765103
SGTC_2728 chlorpromazine 9.18 µM 1.13376311180266 0.169015179310893 no 629 0.128446964121034 568 2726 A thorazine and dopamine antagonist.
SGTC_2186 6124449 200 µM 1.13235698789046 0.169305334199804 no 630 0.128742190117097 669 3834182 YLR033W RSC58
SGTC_1463 k081-0032 34.1 µM 1.13053688822268 0.169681387856875 no 631 0.129125031959484 554 977755
SGTC_1674 st016616 23.6 µM 1.1293580849014 0.169925227903491 no 632 0.129373403529233 667 625830
SGTC_2818 7996756 12.99 µM 1.12758607877877 0.170292196694154 no 633 0.129747384332971 595 2241621
SGTC_3285 9112818 20.8695 µM 1.12721590562618 0.170368920756162 no 634 0.129825603588049 719 17017947 YPR165W RHO1
SGTC_1265 0819-1001 68.8 µM 1.12369189292625 0.171100434859757 no 635 0.130571878432061 646 3106768
SGTC_1312 1218-2183 165 µM 1.12057382245963 0.17174935601252 no 636 0.131234656467488 715 6744073
SGTC_339 3091-4833 71.4 µM 1.11864454990525 0.172151655174218 no 637 0.131645904878076 695 3240077
SGTC_582 0987-0078 156 µM 1.11761792207642 0.172365976423377 no 638 0.131865105524669 818 1625765
SGTC_730 1436-0052 41.2 µM 1.11366687622759 0.173192393286304 no 639 0.132711062277948 654 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3267 9137951 49.47 µM 1.11211361446055 0.173517969696222 no 640 0.133044651881756 650 16643986
SGTC_819 1013-0258 27.7 µM 1.11163019622798 0.173619377550199 no 641 0.133148591910597 687 5753198
SGTC_3328 9140624 29.0385 µM 1.10979764393597 0.17400413897134 no 642 0.133543117404924 721 4904392
SGTC_3032 9089427 49.47 µM 1.10516500166289 0.174979220641961 no 643 0.134544049458843 663 17173707
SGTC_1534 6-azauridine 81.6 µM 1.10379043320753 0.17526920643169 no 644 0.134842027882527 751 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_66 0109-0187 42.4 µM 1.10351415360414 0.175327528510617 no 645 0.134901974273786 642 759417
SGTC_204 PMA1.184 62.41 µM 1.10233785945188 0.175575979587236 no 646 0.135157407956726 759 2252213 YGL008C PMA1
SGTC_1637 st007924 17.4 µM 1.10223184623672 0.175598382133224 no 647 0.135180445133123 698 683336
SGTC_2869 9037858 32.47 µM 1.09993769793281 0.176083621622602 no 648 0.135679634052438 650 27187042
SGTC_1998 st075797 76.8 µM 1.09831974164147 0.176426348439806 no 649 0.136032447204107 794 24208315
SGTC_2173 5763948 167 µM 1.09420972325784 0.177298857291402 no 650 0.136931503998367 726 2867177
SGTC_2234 tolnaftate 200 µM 1.09046999324846 0.178095121568659 no 651 0.137753082173348 667 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.09031983600126 0.178127140095331 no 652 0.137786140186479 729 688664
SGTC_1230 0170-0365 3.77 µM 1.08771252170464 0.178683684791028 no 653 0.13836101906121 857 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2787 5284540 71.43 µM 1.08537288472225 0.179184023364226 no 654 0.138878268403781 711 736958
SGTC_1512 0259-0544 12.2 µM 1.08479028001358 0.179308752085386 no 655 0.139007275753301 783 18476
SGTC_430 0958-0115 16.4 µM 1.08298290114946 0.179696037640592 no 656 0.13940800634216 691 6833180
SGTC_499 genistein 192 µM 1.08246252760727 0.179807640775776 no 657 0.139523528705671 692 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1795 st049545 62.3 µM 1.08048585671935 0.180231968844836 no 658 0.139962940771389 708 5291882
SGTC_2417 cerulenin 830 nM 1.07922772770935 0.180502375971391 no 659 0.140243110926543 698 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1947 st076332 61.6 µM 1.07818187048136 0.18072735354288 no 660 0.14047630046542 666 24208416
SGTC_2508 celastrol 40.54 µM 1.07805921928302 0.18075374893299 no 661 0.140503664623376 671 122724 Celastrol is a natural product and antioxidant.
SGTC_2488 5268135 45.7 µM 1.07758058758502 0.180856776916692 no 662 0.140610484604711 801 1270356 YLR208W SEC13
SGTC_2227 7312221 64.1025 µM 1.077457600222 0.180883256534777 no 663 0.140637941556219 733 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1659 st012954 42.1 µM 1.07426082715911 0.181572385422681 no 664 0.141352898392584 709 24207262
SGTC_1061 3448-9325 110 µM 1.0716792539007 0.182130093157183 no 665 0.141932061090956 709 723482
SGTC_2029 5175081 200 µM 1.06901470436743 0.182706848306803 no 666 0.142531521824505 775 1380876
SGTC_2095 5432005 200 µM 1.06820335725796 0.182882694701068 no 667 0.142714395351515 696 783734
SGTC_1741 st038134 10.228 µM 1.0625784422126 0.184104707034796 no 668 0.143986583799851 787 1272587
SGTC_3330 9141424 71.43 µM 1.06216042474956 0.184195723753078 no 669 0.144081431293381 792 27261020
SGTC_3037 9091026 49.47 µM 1.06214795242925 0.184198439834553 no 670 0.14408426189003 826 25236398 YIL048W NEO1
SGTC_1275 0867-0008 21.1 µM 1.06210812111964 0.184207114015566 no 671 0.144093301868207 744 3422836
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.06078128506911 0.184496208260858 no 672 0.144394654624075 730 390807
SGTC_1873 rapamycin 2 nM 1.0575378711771 0.185204078313853 no 673 0.145133090109093 786 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_390 dec-rvkr-cmk 16.7 µM 1.05715687773747 0.185287340103624 no 674 0.145219998265585 769 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2465 5809242 33.21 µM 1.0559299534372 0.185555628386119 no 675 0.145500109062289 747 2731748
SGTC_734 2023-0417 80 µM 1.05563810635578 0.185619481288444 no 676 0.145566792157763 735 3935732
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.05459133767828 0.185848614785587 no 677 0.145806133604955 720 5355888
SGTC_593 1203-0218 61.7 µM 1.04769859414498 0.187361785859781 no 678 0.147388747748661 788 3666956
SGTC_1394 3474-0001 65.7 µM 1.04759764132085 0.187384004577419 no 679 0.147412012316219 656 5017666 YIL048W NEO1
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.04661958521748 0.18759934936762 no 680 0.147637532639532 723 279621
SGTC_2183 6420625 130.508 µM 1.04512133033726 0.187929525995267 no 681 0.147983448395297 811 2897619
SGTC_332 4112-0506 40.9 µM 1.04420563714061 0.188131497636364 no 682 0.148195129716798 755 2790355
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.04189510182811 0.188641720497357 no 683 0.148730157653359 815 66535 A nucleotide analog.
SGTC_2244 6635614 200 µM 1.04041648864056 0.188968681740753 no 684 0.149073222220381 617 836499
SGTC_2309 7664088 163.95 µM 1.03761868594482 0.189588305899121 no 685 0.1497238074792 827 704922
SGTC_1282 0886-0010 32.4 µM 1.03723086078211 0.189674295351345 no 686 0.149814139410693 856 2836211 YNL267W PIK1
SGTC_1084 voriconazole 435 nM 1.03698067484957 0.189729779856828 no 687 0.149872431806445 787 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3078 9116413 49.47 µM 1.03367109900284 0.190464693825589 no 688 0.150644974265714 707 17177322
SGTC_3125 9127534 49.47 µM 1.03212677998082 0.190808217746847 no 689 0.151006364983419 652 1639235
SGTC_785 1270-0111 65.3 µM 1.03205705245947 0.190823737154238 no 690 0.151022695731224 754 6741994
SGTC_920 mycophenolic acid 780.421 nM 1.02951881528205 0.191389205305642 no 691 0.151617971452732 747 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_162 k030-0015 37.8 µM 1.02939451526742 0.191416923196056 no 692 0.151647162704581 812 1809920 YMR134W ERG29
SGTC_3013 9080133 71.4286 µM 1.02699005619579 0.191953581882595 no 693 0.152212573213256 835 17050193
SGTC_2716 st080858 38.6235 µM 1.02438845323681 0.192535277834418 no 694 0.152825916821625 807 5296050
SGTC_3352 9151559 45.5865 µM 1.02179904002914 0.193115316997468 no 695 0.153438011908362 754 17159339
SGTC_2240 6690706 185.951 µM 1.01774262590411 0.194026112249884 no 696 0.154400142181133 664 805876
SGTC_34 0469-0683 81.75 µM 1.01517068447451 0.194604949184249 no 697 0.155012236093784 788 3690923
SGTC_2674 ligustilide 100 µM 1.01486026826668 0.194674881944596 no 698 0.155086219975971 742 5319022 A signalling regulator.
SGTC_2996 9066192 71.4286 µM 1.01391948880329 0.194886920773161 no 699 0.155310585562247 761 6472854
SGTC_3083 9117465 49.47 µM 1.01247355885829 0.195213087301919 no 700 0.155655841442932 777 16420915
SGTC_393 acivicin 6.25 µM 1.01077692481995 0.195596229261294 no 701 0.156061604848358 726 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2565 isoliquiritigenin 100 µM 1.00853276214214 0.19610371755558 no 702 0.156599383892924 627 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2841 9004761 38.96 µM 1.00676928934284 0.196503063839851 no 703 0.15702282798832 707 2991039
SGTC_1068 loratadine 26.9 µM 1.00665463074209 0.196529045842036 no 704 0.157050385799024 758 3957 A H1 histamine antagonist.
SGTC_2247 cerulenin 830 nM 1.00563978752738 0.196759103265731 no 705 0.157294438642967 788 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1213 1315-0166 115 µM 1.00315675304319 0.197322676049986 no 706 0.157892617738464 686 768401
SGTC_2245 6637752 200 µM 1.00058772018618 0.197906794346002 no 707 0.158513084642352 703 681890
SGTC_12 0849-0099 9.267 µM 0.998642555052773 0.198349758548985 no 708 0.158983938803263 794 6071388
SGTC_71 0417-1750 47.813 µM 0.998506892285898 0.198380674758749 no 709 0.159016812007938 844 6811472
SGTC_521 r062-0005 13.8 µM 0.996677878814407 0.198797772743892 no 710 0.159460445252858 780 2832033
SGTC_1986 st071812 45 µM 0.995268833248108 0.199119459252822 no 711 0.159802765897069 764 11838594
SGTC_1065 prochlorperazine maleate 2.48 µM 0.995254302980176 0.199122778160212 no 712 0.159806298456253 834 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_3149 9097855 49.47 µM 0.992562908253165 0.199738103311901 no 713 0.160461504088729 795 25236625 YMR079W SEC14
SGTC_129 0088-0017 176.636 µM 0.991546036369578 0.199970884973298 no 714 0.160709512296475 779 182446
SGTC_2447 5741742 33.78 µM 0.989838447826694 0.200362151812331 no 715 0.161126544460444 816 1776504
SGTC_872 0588-0139 234 µM 0.988199262791283 0.200738177381452 no 716 0.161527534578581 825 2047100
SGTC_1613 st002381 52.1 µM 0.985976396466584 0.201248774344666 no 717 0.162072347814273 835 551167
SGTC_283 0987-0079 11.7 µM 0.984670387006926 0.201549130207067 no 718 0.162393001578411 861 411556
SGTC_2198 6589944 200 µM 0.982942834175115 0.201946844888781 no 719 0.162817787308489 735 5290268
SGTC_323 4013-0906 34.3 µM 0.981846072268848 0.202199583429899 no 720 0.163087843331505 847 2910086
SGTC_2248 tofa 1.1 µM 0.98071551634286 0.202460307455254 no 721 0.163366525019377 791 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1124 fisetin 1.16336 µM 0.976517782036651 0.203430128473559 no 722 0.164403970156172 771 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1685 st024049 53.0905 µM 0.97641265013915 0.203454453079905 no 723 0.164430007584037 801 1941139
SGTC_843 0310-0051 143 µM 0.972855791770094 0.204278433457126 no 724 0.165312489645541 825 2065037
SGTC_2606 farnesol 9.78 µM 0.972640123446127 0.204328458905196 no 725 0.16536609687101 826 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1643 st009866 20.2 µM 0.972275312425491 0.204413095419383 no 726 0.165456801095062 834 3156273 YOR207C RET1
SGTC_1089 terbinafine 2.25 µM 0.972014430471189 0.204473633083844 no 727 0.165521684809804 836 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_980 1473-0395 201 µM 0.970606817009305 0.204800453888429 no 728 0.165872054994935 752 768876
SGTC_3048 9093155 49.47 µM 0.968586186609498 0.205270148134413 no 729 0.166375849062902 776 25236002
SGTC_714 4296-0578 26.1 µM 0.967647634652854 0.205488531416457 no 730 0.166610189403114 818 1589775
SGTC_3052 9092717 49.47 µM 0.96676021151739 0.205695144822801 no 731 0.166831959591875 801 25237534
SGTC_278 4092-0821 23.9 µM 0.965048101418289 0.206094113381976 no 732 0.167260359833985 850 877900
SGTC_1696 st025591 34.7925 µM 0.963791912000744 0.206387131556281 no 733 0.167575131225251 844 2787147
SGTC_1210 3013-0140 750 nM 0.956483513304403 0.208096775214053 no 734 0.16941400493962 902 905973
SGTC_2526 patulin 37.61 µM 0.954931387376073 0.208460935062151 no 735 0.169806197886304 885 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_680 0417-1641 114 µM 0.950049168747024 0.209608848890952 no 736 0.171043634834753 810 2835990
SGTC_400 oxethazaine 37.5 µM 0.948729201503754 0.209919838631702 no 737 0.171379179053337 821 4621 A local anesthetic.
SGTC_244 nsc-207895 1.295 µM 0.946634742374563 0.210413857994623 no 738 0.171912466999503 750 42640
SGTC_3003 9075612 71.4286 µM 0.946025285344011 0.210557738507734 no 739 0.172067844814102 829 6501993
SGTC_1513 0337-0559 19 µM 0.945438269708664 0.210696375631127 no 740 0.172217586036954 786 775073
SGTC_1199 1638-0010 4.46 µM 0.944290239388592 0.210967663882864 no 741 0.17251067618051 839 3111136
SGTC_767 0929-0023 86 µM 0.9435705999365 0.211137824500705 no 742 0.172694560979937 930 1204563
SGTC_209 4077-0173 175.592 µM 0.941850198580623 0.211544943705898 no 743 0.173134670186857 772 15993494
SGTC_3072 9116419 49.47 µM 0.93892231592569 0.212238859376122 no 744 0.173885315359154 789 17170162
SGTC_2427 5545055 42.75 µM 0.938551629413409 0.212326807814556 no 745 0.173980498671811 922 5372858
SGTC_1251 0490-5699 265 µM 0.938326753129095 0.212380171949156 no 746 0.174038257592726 946 3883818
SGTC_2171 5739187 198.077 µM 0.937255965072688 0.212634382162656 no 747 0.174313454069104 813 2262761
SGTC_2914 7968218 45.32 µM 0.933654806511696 0.213490617071087 no 748 0.175240992199947 826 2977111
SGTC_3260 9137109 49.47 µM 0.933637745124694 0.213494678474283 no 749 0.175245394079509 739 17478346
SGTC_1789 tunicamycin 25 nM 0.93271985235031 0.213713245989716 no 750 0.175482316016561 871 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1966 st070145 16.1 µM 0.926929878246357 0.215094948569676 no 751 0.176981471527098 857 3748532
SGTC_3129 9127257 49.47 µM 0.925354049553823 0.215471895655555 no 752 0.177390886215437 738 837894
SGTC_2113 5491891 107.031 µM 0.925250806435286 0.215496605357448 no 753 0.17741773057579 879 789979
SGTC_1870 st057514 26.5 µM 0.922746859044078 0.216096390971921 no 754 0.17806956998666 864 5393161
SGTC_160 3453-0671 289.699 µM 0.92160869093702 0.21636934255486 no 755 0.178366361779764 957 5322268
SGTC_1539 benzyladenosine 56 µM 0.921548877968626 0.216383692213217 no 756 0.178381967386238 865 92208 A nucleotide analog.
SGTC_1151 3909-8316 15.3 µM 0.919941895324269 0.216769427660977 no 757 0.178801561975963 884 800431
SGTC_2264 7948757 110.76 µM 0.919127437508989 0.216965079482801 no 758 0.17901445974559 848 2971411
SGTC_1874 staurosporine 7.6 µM 0.916776278053539 0.217530455256142 no 759 0.179629942849783 924 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2534 helenine 20.12 µM 0.915257029341689 0.217896235942153 no 760 0.180028355954894 844 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2053 5265679 138 µM 0.912877664371552 0.218469813987155 no 761 0.180653442918917 889 764595
SGTC_1728 st035614 33.7865 µM 0.909358514791338 0.219319744500412 no 762 0.18158045623988 945 15945546
SGTC_3038 9091290 49.47 µM 0.908766057473872 0.219463019006214 no 763 0.18173681344664 880 25236843
SGTC_1832 st054113 55 µM 0.908469085130738 0.219534856331854 no 764 0.181815220001708 883 1251267
SGTC_2074 5212007 75.395 µM 0.906253904186614 0.220071132438893 no 765 0.182400738841134 851 758611
SGTC_337 1315-0038 354 µM 0.904298331309156 0.220545183593334 no 766 0.18291861569223 885 1626437
SGTC_2131 toluylene red 5.2905 µM 0.903639989676705 0.22070490398084 no 767 0.183093164662951 877 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1759 st043059 70 µM 0.898708236624159 0.221903502654884 no 768 0.184404044310939 911 669426
SGTC_676 falcarinol 140 µM 0.897994431372516 0.222077291202594 no 769 0.184594259132142 952 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_842 0271-0008 11.1 µM 0.897779624856908 0.22212960486275 no 770 0.184651524646813 945 1221709
SGTC_1666 st014829 29 µM 0.897415543776194 0.222218288690932 no 771 0.184748610662584 932 3858230
SGTC_1834 st055981 52.8 µM 0.895941505925392 0.222577545132638 no 772 0.185142002442979 925 471719 YDL150W RPC53
SGTC_927 2425-1185 123 µM 0.892674875232442 0.223374876001718 no 773 0.186015654481811 881 730375
SGTC_1416 3966-0321 25.3 µM 0.89237715604832 0.223447625085669 no 774 0.186095405605269 923 582530 YLR208W SEC13
SGTC_2687 chenodiol 100 µM 0.891811264046405 0.223585940613058 no 775 0.186247051577619 864 5702181 A cholesterol synthesis inhibitor.
SGTC_3342 9147791 14.508 µM 0.888801668552862 0.224322364613868 no 776 0.18705483949676 942 1838168
SGTC_2616 abietic acid 100 µM 0.887400489251442 0.224665691218288 no 777 0.18743166009427 969 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3198 9112019 49.47 µM 0.886471356684137 0.224893517926419 no 778 0.187681791204412 922 45595555
SGTC_1571 st070080 73.4 µM 0.883183022629888 0.225700880602142 no 779 0.188568696440554 929 4315245
SGTC_647 0140-0236 81 µM 0.882626923244612 0.225837577881704 no 780 0.188718938526147 1009 990837
SGTC_1672 st016598 6.51 µM 0.882173960272738 0.225948957331042 no 781 0.188841370624537 886 4665860 YNL267W PIK1
SGTC_1690 st023502 41.2 µM 0.881549661175442 0.226102517653397 no 782 0.1890101936387 917 24207482
SGTC_2731 amoxapine 43.43 µM 0.877164153586936 0.227182892288907 no 783 0.19019874161558 900 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1172 0370-0043 85 µM 0.8768687055092 0.227255780714718 no 784 0.190278977886512 939 376585
SGTC_517 1365-0151 113 µM 0.876356341005206 0.227382214678038 no 785 0.190418172492896 904 768657
SGTC_3142 9086498 49.47 µM 0.875919695182636 0.227489995139967 no 786 0.190536845864562 883 25236367
SGTC_1357 1503-1303 39.5 µM 0.874920437197338 0.227736757488394 no 787 0.190808599064105 969 292895
SGTC_852 0418-0143 439 µM 0.874668958260081 0.227798882822308 no 788 0.190877027455826 1010 5369229
SGTC_2580 diallyl disulphide 81.36 µM 0.872266909593516 0.228392765108546 no 789 0.191531392624352 885 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_3055 9094636 49.47 µM 0.871916567409945 0.22847945631917 no 790 0.191626947415247 911 25236176
SGTC_833 3852-0053 558 µM 0.871395925745474 0.228608321811475 no 791 0.191769004812079 991 3123681
SGTC_3257 9139206 32.98 µM 0.871319619635763 0.228627211981827 no 792 0.191789830397366 922 4910041
SGTC_704 1310-0270 142 µM 0.868324968402246 0.229369253073481 no 793 0.192608228600006 990 5718033
SGTC_597 k018-0003 82.8 µM 0.867572522941409 0.229555912640384 no 794 0.192814196939484 1038 6786234
SGTC_3111 9122088 49.47 µM 0.865863663087304 0.229980146423041 no 795 0.193282465971402 854 16876704
SGTC_2904 7225135 42.03 µM 0.865056989226939 0.230180559964079 no 796 0.193503755099887 999 4446116
SGTC_893 0958-0369 48.9 µM 0.864930509472803 0.230211991998374 no 797 0.193538465405078 984 6819948
SGTC_594 1487-1584 10.8 µM 0.864559433852565 0.230304223469065 no 798 0.193640322968703 970 5013332
SGTC_169 k015-0017 16.025 µM 0.864343720153672 0.230357848968521 no 799 0.19369954983504 899 1840002
SGTC_2007 4011539 71.82 µM 0.863946755287821 0.23045655097304 no 800 0.193808570314207 927 45595301
SGTC_2726 cimetidine 79.27 µM 0.863735302385335 0.230509136623128 no 801 0.19386665796528 967 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2059 5238311 157 µM 0.862341215116687 0.230855996223199 no 802 0.194249889417484 908 703021
SGTC_1280 0880-0253 10.1 µM 0.860112098698869 0.231411222608285 no 803 0.194863626294219 948 6836607
SGTC_1945 st075991 56.6 µM 0.85679585980398 0.23223860472677 no 804 0.195778857105069 863 1084980
SGTC_60 0986-0278 202 µM 0.854239541861674 0.232877512909472 no 805 0.196486139012477 864 3110598
SGTC_2911 7942208 15.64 µM 0.852771085102676 0.233244969810323 no 806 0.196893130832427 917 1243384
SGTC_2627 acetyl isogambogic acid 100 µM 0.851991602711104 0.233440152994723 no 807 0.197109376385334 943 6857789 A caspase activator and apoptosis inducer.
SGTC_2051 5263410 176 µM 0.848968791363333 0.234197924354024 no 808 0.197949329156856 1015 227584
SGTC_3295 9122362 53.5725 µM 0.84883829031818 0.234230669555537 no 809 0.197985640279067 934 4730473
SGTC_3087 9117406 49.47 µM 0.846463780749072 0.234826921717284 no 810 0.198647035423764 940 42546093
SGTC_2444 5485484 36.41 µM 0.845957219140891 0.234954230562399 no 811 0.198788305191675 1008 6790631
SGTC_1817 st052116 64.4 µM 0.845898534901113 0.23496898152484 no 812 0.198804674950906 959 4361398
SGTC_2929 9013348 24.6 µM 0.845528585610549 0.235061984337908 no 813 0.19890788969334 945 2995952
SGTC_3308 9128332 17.569 µM 0.845108632303501 0.235167582469916 no 814 0.199025094538914 1025 17332805 YDL196W YDL196W
SGTC_59 0330-0160 1.33 µM 0.845102517529377 0.235169120236063 no 815 0.199026801419662 1053 4293482
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.842858609481587 0.235733801350219 no 816 0.199653762270315 974 6312947
SGTC_1375 2910-0797 186 µM 0.841876142740269 0.235981274982617 no 817 0.199928642795403 953 742508
SGTC_1107 amlodipine 47 µM 0.841747576941635 0.236013670022947 no 818 0.199964630548464 934 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2022 5136654 200 µM 0.841713781542386 0.236022185939498 no 819 0.199974091101813 955 1713771
SGTC_2313 7726885 200 µM 0.841176584854598 0.236157573908231 no 820 0.200124508000584 935 726423
SGTC_2389 9091542 195.52 µM 0.840525177855132 0.236321803309399 no 821 0.200306995376457 959 3626624 YOL127W RPL25
SGTC_2926 9010726 65.15 µM 0.838764650767233 0.236765972865858 no 822 0.200800695434381 976 2994293
SGTC_588 3970-1144 52.9 µM 0.837869520748977 0.236991984299511 no 823 0.201051994234101 972 1888707
SGTC_2152 5568786 200 µM 0.836518676024576 0.237333283553408 no 824 0.201431587323796 967 5399883
SGTC_1181 1222-0449 220 µM 0.835963015485321 0.237473752924976 no 825 0.201587854881836 985 658318
SGTC_1655 st012546 55.1 µM 0.835005926918821 0.237715809102775 no 826 0.20185718564783 936 720985 YLR208W SEC13
SGTC_1857 st056007 79.3 µM 0.834619620772922 0.237813547676821 no 827 0.201965955636879 984 619834
SGTC_661 1304-0007 33.6 µM 0.833958392667933 0.237980894862552 no 828 0.202152215210693 950 3117130
SGTC_1883 5-benzylidenerhodanine 20 µM 0.833318697571064 0.238142853776186 no 829 0.202332506983994 1015 1273210
SGTC_2844 9010103 25.97 µM 0.83248904228614 0.238352997013413 no 830 0.20256648035854 935 2480525
SGTC_3116 9124943 49.47 µM 0.831244935220521 0.23866830690267 no 831 0.202917637366175 949 41905195 YPL160W CDC60
SGTC_1369 1866-0067 208 µM 0.829790871063333 0.239037117982725 no 832 0.20332851655527 1049 3531355
SGTC_1337 1486-1011 40.3 µM 0.826097848989172 0.239975220744324 no 833 0.204374293889682 1051 X1337
SGTC_3235 9132602 49.47 µM 0.825327672304961 0.240171113990944 no 834 0.204592792712274 1033 4912240
SGTC_1235 benzylparaben 21.5 µM 0.824516380576405 0.240377559008134 no 835 0.204823106111611 951 7180
SGTC_2891 9063876 19.48 µM 0.821756592095421 0.241080550600134 no 836 0.205607721655924 961 6472478
SGTC_994 3910-0338 138 µM 0.819491940499272 0.24165825160586 no 837 0.206252899179444 1038 3479481
SGTC_1331 1472-0049 76.2 µM 0.818583395463178 0.24189022783742 no 838 0.206512071860878 1003 24051409
SGTC_793 0488-0545 106 µM 0.818223418476986 0.241982173147519 no 839 0.206614812680116 988 292548
SGTC_1565 sinapyl alcohol 95.1 µM 0.817906281122368 0.242063192064581 no 840 0.206705351742989 1014 5280507 A phenol propionate derived from cinnamic acid.
SGTC_2481 5478948 45.16 µM 0.817812627226423 0.242087120590388 no 841 0.206732093344248 980 77792
SGTC_1994 st072947 40.9 µM 0.816527420846436 0.242415619743639 no 842 0.207099273498549 994 5286565 YDL195W SEC31
SGTC_2963 9082507 9 µM 0.816367547368876 0.242456500336812 no 843 0.207144975905108 965 16459611
SGTC_2353 9059630 146.67 µM 0.816326527529622 0.242466989954159 no 844 0.207156703047973 1044 4779114
SGTC_174 3553-0389 74.3 µM 0.816312048999263 0.242470692471129 no 845 0.207160842402084 962 738071
SGTC_1274 0865-0114 173 µM 0.812285960665241 0.243501449827271 no 846 0.208313782253013 1021 870624
SGTC_2339 9000433 200 µM 0.810134284312252 0.244053290057391 no 847 0.208931500835622 950 2988954
SGTC_191 3914-0123 66.505 µM 0.809708345021912 0.244162610594939 no 848 0.209053910340512 901 3144412
SGTC_880 0833-0487 87.2 µM 0.803730912739521 0.245699545366085 no 849 0.210776198545876 1010 76075
SGTC_237 nikkomycin 200 µM 0.803062115295043 0.245871831067756 no 850 0.210969416668837 1043 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1137 ixabepilone 100 µM 0.802814549472807 0.245935621750656 no 851 0.211040965700927 1013 154225 A novel microtubule stabilizer.
SGTC_1640 st009078 66.4 µM 0.801156092795135 0.246363187881015 no 852 0.211520643168216 976 690618
SGTC_504 lovastatin 124 µM 0.797264443296812 0.2473680550413 no 853 0.212648733031417 1030 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1912 st060209 90.8 µM 0.796793218506501 0.247489879044932 no 854 0.212785567129175 1003 688787
SGTC_2094 5332512 191.667 µM 0.796370764318182 0.247599121811928 no 855 0.212908282920299 1085 755774
SGTC_2063 5246145 200 µM 0.795740654331244 0.247762110307917 no 856 0.213091395929919 1067 711240
SGTC_86 0417-1630 471.922 µM 0.795726762193973 0.247765704387087 no 857 0.213095434086984 1141 3634867
SGTC_1594 piperine 70.1 µM 0.795721725694413 0.247767007402838 no 858 0.213096898104294 1028 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_643 k048-0106 28.4 µM 0.795689482785977 0.247775349199285 no 859 0.213106270660702 1040 6763920
SGTC_96 0929-0093 37.281 µM 0.795597608786153 0.247799119409781 no 860 0.213132978448799 990 6991579
SGTC_2626 ethyl orsellinate 100 µM 0.794914026483423 0.247976018280456 no 861 0.213331757241994 1039 75653 A natural product.
SGTC_1378 2093-0007 380 nM 0.794249373324454 0.24814808322091 no 862 0.21352513522992 1014 3618014
SGTC_181 1447-1644 8.07 µM 0.793985963828038 0.248216292100494 no 863 0.213601801348542 1042 534600
SGTC_2984 9022109 38.96 µM 0.7920444078091 0.248719358881612 no 864 0.214167391594085 1030 6459207
SGTC_197 4544-0043 41.561 µM 0.791302449462367 0.248911747254176 no 865 0.214383759700713 1089 896523
SGTC_3344 9148862 3.898 µM 0.790703281603311 0.249067168116347 no 866 0.214558580332235 1069 4905352
SGTC_3250 9135583 49.47 µM 0.789472142558285 0.249386680805298 no 867 0.21491805266698 1035 7699353
SGTC_841 0251-0215 91.2 µM 0.789155249432008 0.249468958078506 no 868 0.215010636819306 1084 3888614
SGTC_3264 9137442 49.47 µM 0.787414440081634 0.249921194260995 no 869 0.215519648186502 1022 17015726
SGTC_930 2810-3379 265 µM 0.786931298201641 0.250046784375515 no 870 0.215661042319173 1108 1015764
SGTC_1131 3454-3128 32.3 µM 0.78556051801691 0.250403293454266 no 871 0.216062501337808 1090 710982
SGTC_3241 9133421 49.47 µM 0.784154382989319 0.250769277271894 no 872 0.216474764105127 1090 17018221
SGTC_662 k832-1615 104 µM 0.783019247958933 0.251064932659109 no 873 0.216807904560754 1024 5878478
SGTC_1591 genipin 88.4 µM 0.782530410006308 0.251192311367042 no 874 0.216951460430527 1003 442424 A DNA cross-linking agent.
SGTC_1928 4'-methoxychalcone 40.3 µM 0.782517908560161 0.251195569373348 no 875 0.216955132420589 1104 641818
SGTC_892 0929-0076 29 µM 0.782055146191747 0.251316185761008 no 876 0.217091082674266 1099 5751038
SGTC_1299 1079-1439 3.74 µM 0.781389373829498 0.251489769252294 no 877 0.217286759495562 1066 323161
SGTC_3089 9117425 49.47 µM 0.780510958647674 0.251718890942853 no 878 0.217545089854616 1034 9401657
SGTC_326 k292-0812 17.5 µM 0.780416661123981 0.25174349361636 no 879 0.21757283204899 1066 3579357
SGTC_2714 st079313 56.9 µM 0.780004234000216 0.251851112738937 no 880 0.217694191500231 1046 2939799
SGTC_875 0709-0210 25.7 µM 0.779504404222226 0.2519815713373 no 881 0.217841322104989 1135 6251364
SGTC_1678 st019265 80.2 µM 0.779031941179678 0.252104919829169 no 882 0.217980449711952 1101 5367020
SGTC_2779 methotrexate 400 µM 0.778664394506667 0.252200899257529 no 883 0.218088717701934 1173 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1786 berberine 21.6 µM 0.777885165583078 0.252404447191218 no 884 0.218318357161391 1021 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1324 1418-0026 34.4 µM 0.77776677947083 0.252435379245261 no 885 0.218353257839713 1069 1372513
SGTC_3203 9113543 49.47 µM 0.777691929941764 0.252454937043602 no 886 0.218375325425188 1048 17018012
SGTC_2054 5233173 129 µM 0.777664485495433 0.252462108336843 no 887 0.218383417082726 1060 6889
SGTC_473 2-arachidonoylglycerol 10 µM 0.776658730754596 0.25272498826356 no 888 0.218680070612698 994 5282280 An endocannabinoid.
SGTC_1333 1482-0047 286 µM 0.774615786372391 0.253259407874433 no 889 0.219283363134533 1098 3811116
SGTC_2470 5664817 21.68 µM 0.774339561857672 0.253331711802848 no 890 0.219365007076852 1106 2859561
SGTC_2256 7954252 200 µM 0.772998125738852 0.253682997453889 no 891 0.21976174493128 968 2972920
SGTC_2990 9074105 71.4286 µM 0.772801628236711 0.253734476279989 no 892 0.21981989482642 1062 6502001
SGTC_995 3931-2021 34.6 µM 0.772042590563306 0.253933382062052 no 893 0.22004460128262 1037 730143
SGTC_407 eburnamonine 100 µM 0.771439775664371 0.254091407953296 no 894 0.220223153200693 1015 3195
SGTC_624 k048-0052 28 µM 0.771022382225364 0.254200856451756 no 895 0.220346832516281 1036 6835531
SGTC_2862 9027634 71.43 µM 0.770152370123687 0.254429069617763 no 896 0.220604756814303 1041 5012562
SGTC_1465 k213-0056 144 µM 0.766475008966786 0.255394864195954 no 897 0.22169685817177 1014 24048857 YMR208W ERG12
SGTC_1511 0906-3109 28.5 µM 0.766170704979519 0.25547487005932 no 898 0.221787368436304 1168 2882180
SGTC_1710 st031758 61.5 µM 0.765709661657601 0.255596109876658 no 899 0.221924538472078 1067 5394341
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.763657649010936 0.256136088638583 no 900 0.222535642508428 1076 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_291 SEC14.278 35.5 µM 0.760949354686419 0.256849674920342 no 901 0.223343658895608 1116 1068044
SGTC_2713 st079149 53.4 µM 0.760729900721195 0.256907542328611 no 902 0.223409205767053 1089 3103253
SGTC_804 1595-0054 20.9 µM 0.75871918799237 0.257438059086654 no 903 0.224010278071125 1051 761523 Stimulates phospholipase C.
SGTC_2267 7931562 200 µM 0.757153132171232 0.25785164922301 no 904 0.224479062645639 1033 934880
SGTC_2034 5197015 53.07 µM 0.756643216009708 0.257986390760087 no 905 0.224631821469373 1081 780676
SGTC_3236 9132701 49.47 µM 0.756330268091612 0.258069102992125 no 906 0.224725602457517 1086 24282524
SGTC_3211 9128781 49.47 µM 0.75527324209082 0.258348576929009 no 907 0.225042525154034 1004 17194361
SGTC_2380 9035439 200 µM 0.753840026267401 0.258727764451632 no 908 0.225472643157987 1158 6462575
SGTC_2917 7979103 53.79 µM 0.749105134574096 0.259982524859669 no 909 0.226896920267378 1120 2980565
SGTC_2300 7976697 71.57 µM 0.748922298156281 0.260031039909331 no 910 0.226952019872739 1020 2236109
SGTC_2760 etidronate 98.04 µM 0.748523776893122 0.26013680240667 no 911 0.227072144435236 1122 3305 A chelator and antioxidant.
SGTC_372 0155-0182 15.9 µM 0.747767881310117 0.260337468423205 no 912 0.227300089262603 1135 771486
SGTC_3056 9094900 49.47 µM 0.746258786784256 0.260738322972958 no 913 0.227755551159677 1080 25236784
SGTC_335 4077-0256 27.6 µM 0.743830219047786 0.261384079559082 no 914 0.228489597863299 1161 3121989
SGTC_1359 1582-0056 520 nM 0.741151474648909 0.262097309627084 no 915 0.229300800967616 1143 3661189
SGTC_78 0336-0123 156.75 µM 0.740777438991365 0.262196977927904 no 916 0.229414198364394 999 6765896
SGTC_213 1246-0773 967 nM 0.739582920549073 0.262515408108592 no 917 0.229776554126197 1111 6251622
SGTC_2435 5706476 10.6 µM 0.737988947754428 0.262940631413633 no 918 0.23026058267123 1159 5725375
SGTC_1732 st034308 51.822 µM 0.736645126567653 0.263299395271236 no 919 0.230669092384736 1044 830119
SGTC_1545 lovastatin 49.4 µM 0.73648592627316 0.263341913993464 no 920 0.230717514672668 1182 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_472 calcifediol 10 µM 0.735944683890381 0.26348649355148 no 921 0.230882181166566 1080 5283731 A vitamin D metabolite.
SGTC_443 clozapine 122 µM 0.735631114323588 0.263570274461195 no 922 0.230977610955986 1046 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1101 ebselen 5.29 µM 0.735206959343161 0.263683623698755 no 923 0.231106730644456 1205 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1856 st057054 55.7 µM 0.735199306100525 0.263685669144676 no 924 0.231109060786144 1162 1266018
SGTC_2505 galangin 7.89 µM 0.735134202196108 0.263703069484204 no 925 0.23112888315245 1037 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2400 5203494 178.7 µM 0.734784963908776 0.263796420499642 no 926 0.231235232896082 1110 6777674
SGTC_566 0958-0068 16.5 µM 0.733662232318365 0.264096639557781 no 927 0.231577311043279 1110 6815365
SGTC_1332 1480-0653 17.5 µM 0.732971314082806 0.264281477964893 no 928 0.23178796277342 1135 5749438
SGTC_423 5-fluorouracil 457 µM 0.732511891369742 0.264404421815578 no 929 0.231928093684423 1120 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1929 genistein trimethyl ether 50.5 µM 0.731440788636624 0.264691167354049 no 930 0.232254979444372 1169 136420
SGTC_1763 st044482 94.5 µM 0.73094762920783 0.264823244503323 no 931 0.232405571036289 1124 88505
SGTC_889 0919-1524 82.7 µM 0.727574883729923 0.265727424849283 no 932 0.233436930035576 1114 3905452
SGTC_3141 9094609 49.47 µM 0.725699934734441 0.266230745369283 no 933 0.234011370907486 1108 25236309 YDL196W YDL196W
SGTC_29 0299-0004 12.984 µM 0.72562998202924 0.266249533151374 no 934 0.234032817934275 1056 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1531 st059297 52.4 µM 0.724366143803037 0.266589088289679 no 935 0.234420489662612 1156 7566702
SGTC_2442 5158906 48.48 µM 0.724210803595774 0.266630838615123 no 936 0.234468163471491 1142 1893835
SGTC_1564 D-Arginine 115 µM 0.723719494657082 0.266762908015894 no 937 0.234618981172051 1137 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_715 0868-0130 184 µM 0.719244770924717 0.267967284182264 no 938 0.235995059203559 1173 2876258
SGTC_2411 st077133 39.94 µM 0.718859240466002 0.268071178041799 no 939 0.23611382622501 1202 1403142 YNL221C POP1
SGTC_2971 9092186 9.93 µM 0.718453830530889 0.268180450947639 no 940 0.236238752853905 1126 25236400
SGTC_1922 5578187 25 µM 0.717127392969346 0.268538131284405 no 941 0.236647747412789 1145 1350412
SGTC_2484 5809818 12.04 µM 0.715390805577148 0.269006772718179 no 942 0.237183796133886 1145 2870548
SGTC_2301 7769476 200 µM 0.714989220908035 0.269115204148366 no 943 0.237307851935714 1139 977820
SGTC_1705 st027868 56.3335 µM 0.710273520351543 0.270390123750975 no 944 0.238767268527217 1192 292948
SGTC_1028 k015-0029 4.8 µM 0.710180485690304 0.270415306595908 no 945 0.238796110231178 1186 4588309
SGTC_508 roscovitine 141 µM 0.709692440933421 0.270547430919493 no 946 0.238947440352965 1197 160355 A CDKinase inhibitor.
SGTC_1140 3229-1848 2.98 µM 0.708314158692981 0.270920735936492 no 947 0.239375093232484 1180 2849525
SGTC_836 0330-0104 1.35 µM 0.704793008911542 0.271875597957183 no 948 0.240469529934393 1199 46494820
SGTC_2814 7977482 42.97 µM 0.704197843263237 0.272037159672412 no 949 0.240654786985107 1215 6456762
SGTC_334 1502-1024 68.5 µM 0.703774908185568 0.272151997251323 no 950 0.240786481076159 1215 3296216
SGTC_405 ebelactone b 50 µM 0.701465879436695 0.272779381593511 no 951 0.241506160526835 1172 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.700138320505068 0.273140416133688 no 952 0.241920463192347 1186 5377381
SGTC_202 3594-0513 34.79 µM 0.699392736978449 0.273343284106347 no 953 0.242153312786475 1170 708429
SGTC_2257 7960413 200 µM 0.699021662493548 0.273444278636559 no 954 0.242269246537971 1173 2974689 YIL048W NEO1
SGTC_1651 st011928 86.1 µM 0.69798619630908 0.273726196864393 no 955 0.242592913340146 1187 720198
SGTC_1054 3429-0080 167 µM 0.696981584002037 0.273999852086265 no 956 0.242907159472113 1207 1162877
SGTC_868 0527-0199 213 µM 0.696885163153841 0.27402612412253 no 957 0.242937331819299 1131 2849450
SGTC_2557 derrustone 83.84 µM 0.695576253241138 0.274382889269226 no 958 0.24334712097481 1202 629853 An antioxidant.
SGTC_3233 9132340 49.47 µM 0.694968521810022 0.274548614474542 no 959 0.243537514415509 1162 17682950
SGTC_3172 9105863 49.47 µM 0.693970464371121 0.274820886655044 no 960 0.243850365821182 1174 2348785
SGTC_855 0428-0020 25 µM 0.693421301277222 0.274970756253339 no 961 0.244022599119486 1189 6812414
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.691183303502236 0.275581934144067 no 962 0.244725177531744 1146 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2126 5251174 33.877 µM 0.690352843928999 0.27580889530232 no 963 0.244986161879748 1231 790722
SGTC_851 0394-0702 453 µM 0.686935066491757 0.276743925417279 no 964 0.246061824034683 1215 762646
SGTC_2864 9034755 47.6 µM 0.68481034094641 0.277325986225228 no 965 0.246731804531152 1215 4930451
SGTC_304 1310-0298 97 µM 0.684605966442038 0.277382005420474 no 966 0.246796300514911 1163 1550234
SGTC_2097 5376186 200 µM 0.683674360325797 0.277637429376925 no 967 0.247090408697981 1181 742755
SGTC_515 4092-1064 102 µM 0.681743041585877 0.278167316185643 no 968 0.247700723035674 1238 717353
SGTC_695 3505-6186 243 µM 0.681304517075789 0.278287700758011 no 969 0.247839412842962 1230 1819379
SGTC_3002 9075603 71.4286 µM 0.681142680347222 0.278332134896162 no 970 0.247890606551745 1213 20105405
SGTC_2258 7960471 200 µM 0.681065255025573 0.27835339413307 no 971 0.247915100450091 1171 2974708
SGTC_2330 7979373 200 µM 0.680693845468841 0.278455385774593 no 972 0.248032615729537 1195 1863007
SGTC_3216 9129716 49.47 µM 0.6796729085458 0.278735835919079 no 973 0.248355796803597 1183 8056934
SGTC_2393 9031399 185.94 µM 0.678853935436254 0.278960906191198 no 974 0.248615207706841 1258 1526623 YDL150W RPC53
SGTC_2825 7998094 58.44 µM 0.676909748373591 0.279495561642782 no 975 0.24923160930238 1196 2987815
SGTC_2041 5107442 45.335 µM 0.675752834437303 0.27981395133801 no 976 0.249598792451635 1236 793005
SGTC_531 3788-1495 174 µM 0.674490759476595 0.280161482515886 no 977 0.249999679274407 1208 2896655
SGTC_2018 5133068 143 µM 0.673461997242308 0.280444922190213 no 978 0.250326708979402 1232 785362
SGTC_158 k038-0087 26.446 µM 0.672251531111305 0.280778601716218 no 979 0.250711790139484 1195 X158
SGTC_570 0987-0065 62.6 µM 0.670644979186446 0.281221763327078 no 980 0.251223360701907 1126 3104428
SGTC_3332 9141069 11.198 µM 0.66917920075985 0.281626387494445 no 981 0.251690586217021 1205 17332883
SGTC_777 1315-0167 517 µM 0.668254651065587 0.281881751239598 no 982 0.251985527732942 1212 4221767
SGTC_3247 9135149 49.47 µM 0.667333261193851 0.282136353174286 no 983 0.252279642578867 1210 8934436 YOR116C RPO31
SGTC_2384 9036245 200 µM 0.66602741915789 0.282497377909159 no 984 0.252696787393705 1243 6462766
SGTC_2751 anetholtrithion 17.25 µM 0.664967411178829 0.282790600418054 no 985 0.253035668643495 1227 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1168 k815-0004 80.5 µM 0.661805016850433 0.283666258889263 no 986 0.254048095258694 1231 642433
SGTC_1329 1447-1697 50.6 µM 0.661484901238825 0.283754970377221 no 987 0.254150697179647 1230 2840515
SGTC_3101 9120531 49.47 µM 0.660170261685658 0.284119426838098 no 988 0.254572286928895 1309 24824904
SGTC_2856 9022925 19.48 µM 0.658603658282664 0.284554027170831 no 989 0.25507515655539 1249 4944862
SGTC_1826 st055655 41.6 µM 0.656919450884856 0.285021606524865 no 990 0.255616355319919 1290 676168
SGTC_2722 naftopidil 47.16 µM 0.65612851415273 0.285241317285594 no 991 0.255870719637883 1245 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2531 methyl deoxycholate 70.07 µM 0.654523508478464 0.285687412464387 no 992 0.256387293294675 1245 16667744 Haematoxylin.
SGTC_1859 st055998 20 µM 0.654445618659252 0.285709069598033 no 993 0.256412376078278 1283 676301
SGTC_1135 dihydrocapsaicin 536.708 nM 0.649929672296353 0.286966054287274 no 994 0.257868825229411 1230 107982 A Capsaicinoid.
SGTC_370 0180-0345 38.7 µM 0.649812478640488 0.286998709233703 no 995 0.257906678712682 1223 3989527
SGTC_755 1995-0008 37.3 µM 0.64808505545527 0.287480244048153 no 996 0.258464969657223 1259 689533
SGTC_1425 4048-4433 7.33 µM 0.642271848999275 0.289103527813921 no 997 0.260348344565777 1317 23734946
SGTC_581 0958-0271 211 µM 0.642128728381274 0.289143547224832 no 998 0.260394802098389 1289 4591145
SGTC_2033 5192550 145 µM 0.641890765595758 0.289210092183728 no 999 0.260472055234037 1259 182073
SGTC_354 2783-3500 4.88 µM 0.641546879055448 0.289306270844822 no 1000 0.260583716705596 1247 6740761
SGTC_441 propafenone 146 µM 0.640643347866791 0.289559043294429 no 1001 0.260877214640683 1240 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_3306 9127676 59.7925 µM 0.640537574983559 0.28958864116138 no 1002 0.26091158441695 1286 41905287
SGTC_2019 4016004 108 µM 0.639746268773079 0.289810113245393 no 1003 0.261168784836185 1246 45595336
SGTC_1092 toremifene 6.32 µM 0.639573832495206 0.289858385536932 no 1004 0.26122484955634 1288 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1949 st076024 69.1 µM 0.639449641763731 0.289893154172025 no 1005 0.261265231888897 1258 2921930
SGTC_2068 5226020 147 µM 0.637633683498893 0.29040177600445 no 1006 0.261856081922488 1296 1810509
SGTC_1421 4029-0249 71.4 µM 0.637155783879169 0.290535697708346 no 1007 0.262011687763199 1373 2894095
SGTC_629 3448-6466 76.7 µM 0.635643509251817 0.290959672403626 no 1008 0.262504401981527 1272 573744
SGTC_2979 9012552 45.46 µM 0.635554907335617 0.290984521411725 no 1009 0.262533284074268 1339 17100905
SGTC_3077 9117319 49.47 µM 0.634950624742726 0.291154022998532 no 1010 0.262730309025532 1283 17154678
SGTC_1179 1021-1431 9.29 µM 0.634364527947333 0.291318467491644 no 1011 0.26292147677163 1296 2840958
SGTC_627 1391-0720 175 µM 0.633202342636946 0.291644676527203 no 1012 0.263300758058596 1270 997839
SGTC_1257 0669-0121 16 µM 0.632456653218127 0.291854070674745 no 1013 0.263544262224555 1319 4307855
SGTC_2572 astragaloside iv 100 µM 0.63173239299055 0.292057514391375 no 1014 0.2637808786729 1322 45006101 An anti-inflammatory agent.
SGTC_2694 st077685 81.9 µM 0.630599782977134 0.292375795277876 no 1015 0.264151120401944 1260 2838096
SGTC_1900 st060200 72.8 µM 0.629950074024005 0.292558446280932 no 1016 0.264363624805686 1292 688945
SGTC_914 3820-6779 408 µM 0.62821473237031 0.29304655815942 no 1017 0.264931640271855 1273 2893481
SGTC_1023 4482-3888 16 µM 0.625121592793408 0.293917523023399 no 1018 0.265945628556093 1334 3303168
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.624578624580173 0.294070535202764 no 1019 0.266123826220649 1336 1273210
SGTC_2502 avocadyne acetate 18.59 µM 0.624513785996526 0.294088809622495 no 1020 0.266145109746479 1270 3952079
SGTC_467 ro 31-8220 72.8 µM 0.62367445936301 0.29432541685548 no 1021 0.266420699857122 1272 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2087 5276107 200 µM 0.622322893882902 0.294706609505123 no 1022 0.266864785111862 1282 144405
SGTC_2832 7992762 51.95 µM 0.621789556538438 0.294857093457879 no 1023 0.267040127159865 1195 2985177
SGTC_2906 7926292 26.41 µM 0.618997580589323 0.295645441624317 no 1024 0.267958976368313 1295 2966319
SGTC_2236 dapsone 200 µM 0.618658026335459 0.295741384914403 no 1025 0.268070833369241 1311 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2953 9074162 66.49 µM 0.618556432350205 0.295770093744154 no 1026 0.268104305338418 1316 16451992
SGTC_3204 9114183 49.47 µM 0.61799757197125 0.295928041607273 no 1027 0.268288469566914 1330 17027248
SGTC_1402 3909-7673 35.9 µM 0.617082939419617 0.296186623075697 no 1028 0.268590010527587 1298 5328014
SGTC_928 2764-0428 58.7 µM 0.613030441838546 0.297333574985531 no 1029 0.269928105650798 1371 662578
SGTC_737 1950-0117 57.9 µM 0.612568917602717 0.297464325780048 no 1030 0.270080707815685 1277 5393513
SGTC_2216 7189485 200 µM 0.609323148883535 0.298384599633454 no 1031 0.271155133078582 1331 731273
SGTC_674 0498-0004 451 µM 0.606872168575876 0.299080384386733 no 1032 0.271967874721665 1292 4231473
SGTC_1386 3228-0095 33.8 µM 0.605832162248233 0.299375843998173 no 1033 0.272313105128643 1367 870181
SGTC_3177 9107506 49.47 µM 0.605599118536386 0.29944206848002 no 1034 0.272390493906977 1285 8897194
SGTC_2015 5119600 184 µM 0.605565919422422 0.29945150327685 no 1035 0.272401519503882 1363 2828786
SGTC_2710 st078562 53.7235 µM 0.60263816895163 0.300284064884166 no 1036 0.273374711366894 1302 17250908
SGTC_2931 9014674 55.67 µM 0.593872835507228 0.302782886268101 no 1037 0.27629858448787 1322 2996810
SGTC_3298 9116858 71.43 µM 0.592828927660766 0.303081103122727 no 1038 0.276647823067503 1416 2506942
SGTC_2836 9010338 19.48 µM 0.591715437159598 0.303399342642453 no 1039 0.277020578758185 1236 2994051
SGTC_1090 efavirenz 20.7 µM 0.590201660454705 0.303832224662214 no 1040 0.277527729529 1371 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_305 1682-2595 20.8 µM 0.589823132980012 0.303940512033538 no 1041 0.277654616006323 1355 226033
SGTC_1745 st081495 74 µM 0.58806621809631 0.304443347180825 no 1042 0.278243923501342 1318 13842402 YBL026W LSM2
SGTC_3109 9122853 49.47 µM 0.586938902666398 0.304766183645955 no 1043 0.278622370548909 1430 1234709
SGTC_2139 5578692 56.4705 µM 0.582981286335524 0.305900754184053 no 1044 0.279952949020599 1344 650991 YMR113W FOL3
SGTC_2890 9046729 58.44 µM 0.581464876236156 0.306335973909761 no 1045 0.280463591955786 1305 903329
SGTC_750 4073-0104 132 µM 0.578072779296554 0.307310517258789 no 1046 0.281607491980444 1251 22330957
SGTC_1094 duloxetine 25.4 µM 0.574691245801739 0.308283381894049 no 1047 0.282750064526865 1374 60834 A selective serotonin reuptake inhibitor.
SGTC_1470 k295-0292 231 µM 0.574638126274534 0.308298675114193 no 1048 0.282768030620968 1432 5045612
SGTC_3063 1327-0034 4 µM 0.574412894834749 0.30836352340084 no 1049 0.282844214522855 1290 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1364 1653-0028 37.6 µM 0.574065350726069 0.308463599494213 no 1050 0.28296178968028 1376 5718652
SGTC_1502 4534-4282 27.7 µM 0.572238828493712 0.308989784423812 no 1051 0.283580092744734 1371 3278949
SGTC_1297 1068-0111 14.1 µM 0.571658024526166 0.309157184794927 no 1052 0.28377683848778 1326 767057
SGTC_3209 9113616 49.47 µM 0.571656870676459 0.309157517399034 no 1053 0.28377722941623 1421 16649353
SGTC_1098 clofazimine 15.1 µM 0.570356850011094 0.309532355477369 no 1054 0.284217844840781 1437 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_3245 9134821 49.47 µM 0.569673390115548 0.309729498636141 no 1055 0.284449620707835 1325 17014901
SGTC_2287 7945887 168.79 µM 0.569180991114536 0.309871564448318 no 1056 0.284616659681888 1410 1245853
SGTC_772 k072-0172 35.3 µM 0.568996479940711 0.309924806497563 no 1057 0.284679264390691 1303 5861980
SGTC_553 k007-0256 45.7 µM 0.567417469698349 0.310380604402375 no 1058 0.285215291809459 1421 6287000
SGTC_2903 5923464 63.88 µM 0.566374548485695 0.310681814398373 no 1059 0.285569596342612 1407 2876576
SGTC_1048 3161-0300 24.5 µM 0.564532383042012 0.311214167188985 no 1060 0.286195933984563 1366 2165101
SGTC_2964 9083345 53.42 µM 0.563883220085842 0.311401857858399 no 1061 0.28641680524646 1348 17741579
SGTC_2793 7325131 81.82 µM 0.562018259520504 0.311941341325247 no 1062 0.287051789237328 1426 4176441
SGTC_215 1287-0124 461.5 µM 0.558198311157313 0.313047610093126 no 1063 0.288354486990434 1476 5560863
SGTC_2206 7254556 146.969 µM 0.55604985116886 0.313670551850155 no 1064 0.289088388101364 1399 4398905
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.555599037495839 0.313801331932709 no 1065 0.289242494793215 1395 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2661 dactinomycin 12.96 µM 0.555013314472994 0.313971283876462 no 1066 0.289442776719013 1403 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1105 epirubicin 18.1 µM 0.552019883027436 0.314840466189478 no 1067 0.290467365420584 1351 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_47 0149-0135 24.25 µM 0.551505828795075 0.314989832041297 no 1068 0.290643486041229 1315 5239155
SGTC_2918 7977171 22.06 µM 0.551442013597894 0.31500837657682 no 1069 0.290665353313148 1363 2236483
SGTC_2440 5628896 157.78 µM 0.551354936158236 0.315033681813696 no 1070 0.290695192996426 1449 5522048
SGTC_1695 st026914 34.495 µM 0.550821871833875 0.315188612490284 no 1071 0.290877894619019 1367 3289191
SGTC_1197 1601-0112 267 µM 0.549279475495552 0.315637080112244 no 1072 0.291406835185952 1380 7350313
SGTC_1358 1509-0022 2.48 µM 0.546647327135207 0.316403031411946 no 1073 0.292310523918753 1420 3258434
SGTC_2436 5633522 8.09 µM 0.545325440255129 0.31678799610724 no 1074 0.292764855051555 1457 5724242
SGTC_203 k066-0004 30.888 µM 0.54384772294407 0.317218577261484 no 1075 0.293273132750189 1468 6795412
SGTC_1665 st014639 11.4 µM 0.541354929734013 0.317945494703135 no 1076 0.2941314830717 1480 981133 YIL048W NEO1
SGTC_2207 7258803 200 µM 0.53947819956839 0.3184932269088 no 1077 0.294778467740992 1437 3666799
SGTC_847 0342-0274 5.54 µM 0.538987141759373 0.318636609922138 no 1078 0.294947863438128 1468 18097
SGTC_220 paclitaxel 373.376 µM 0.538740591756782 0.318708609820158 no 1079 0.295032930435868 1454 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_374 0880-0231 82.3 µM 0.53818770416102 0.318870094242884 no 1080 0.295223733984332 1396 6833587
SGTC_2673 kobusone 100 µM 0.536693861806107 0.319306579581578 no 1081 0.295739548350047 1490 6710676 An epoxy ketone and protein crosslinker.
SGTC_2525 harmine 47.85 µM 0.536016477180177 0.319504586990726 no 1082 0.295973581381085 1487 5280953 A monoamine oxidase inhibitor
SGTC_2812 7970281 58.44 µM 0.531206119402629 0.320912188474657 no 1083 0.297637976443816 1543 2233435
SGTC_550 4123-0385 25.7 µM 0.529654071801546 0.321366897974942 no 1084 0.298175898526839 1405 5731123
SGTC_2586 curcumin 80 µM 0.528488191216554 0.321708646831376 no 1085 0.298580270525207 1511 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_712 r015-0009 80.6 µM 0.527510891062808 0.321995234317511 no 1086 0.298919427653416 1483 6813872 YLR060W FRS1
SGTC_275 trichlorophene 5.69 µM 0.525633590262603 0.322546038636303 no 1087 0.299571406734987 1481 62616
SGTC_2251 lansoprazole 556 µM 0.524383985666629 0.322912891580901 no 1088 0.300005746355134 1375 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1662 st014054 52 µM 0.522518830650324 0.323460775450885 no 1089 0.300654569464306 1430 2838777
SGTC_2194 5927483 104.545 µM 0.522442664325621 0.323483157234655 no 1090 0.300681078558013 1468 760979
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.521947617302309 0.323628644375284 no 1091 0.300853401507822 1469 4213774
SGTC_1737 st035557 69.7 µM 0.52187589522438 0.323649724690332 no 1092 0.300878371234222 1410 5716916
SGTC_2150 5556613 200 µM 0.520048216653643 0.324187100690596 no 1093 0.301514984614836 1471 743190
SGTC_1822 st052468 42 µM 0.519271833423453 0.324415484683407 no 1094 0.301785596173364 1403 2873678
SGTC_324 1315-0088 19.6 µM 0.518448160024567 0.324657851961108 no 1095 0.302072810203893 1458 6787421
SGTC_897 1000-0139 31.4 µM 0.517243659204558 0.325012412035941 no 1096 0.302493039175133 1529 6151020
SGTC_1844 rapamycin 4 nM 0.515838788162862 0.325426153909346 no 1097 0.302983504597034 1446 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2969 9091408 28.7 µM 0.515215011446144 0.325609928447238 no 1098 0.303201390150588 1404 4286311
SGTC_666 0272-0154 136 µM 0.514784058343029 0.325736918849484 no 1099 0.303351963219689 1463 6870312
SGTC_882 0843-0131 351 µM 0.514735276328118 0.325751294884562 no 1100 0.303369009540755 1467 5425421
SGTC_1958 st076513 41.9 µM 0.514047395296817 0.32595404065648 no 1101 0.30360942731414 1407 732122 YGL099W LSG1
SGTC_3029 9088683 49.47 µM 0.512984179991127 0.326267513543297 no 1102 0.303981193492257 1459 25236615
SGTC_5 0352-0601 109.883 µM 0.50887406252458 0.327480472287698 no 1103 0.30542025082899 1436 762456
SGTC_853 0419-0306 21 µM 0.506639888687804 0.328140577139332 no 1104 0.306203757463882 1409 762713
SGTC_2555 cholic acid 100 µM 0.505479575705687 0.328483613092238 no 1105 0.306611020093383 1474 6708657 Influences liver metabolism.
SGTC_1926 methyl fluorone black 53.6 µM 0.502169232581412 0.329463079938343 no 1106 0.307774241764159 1376 72721 Reacts with homocysteine.
SGTC_1644 st010134 20.9 µM 0.502151384564378 0.329468364003444 no 1107 0.307780518633795 1453 3818134
SGTC_2409 alverine citrate 63.97 µM 0.497786341343972 0.330761694436945 no 1108 0.30931732201128 1614 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2922 7999257 32.47 µM 0.495003017983528 0.331587430145925 no 1109 0.3102989950816 1460 2988377
SGTC_1401 3807-4679 7.6 µM 0.494989049971368 0.331591576140967 no 1110 0.310303924991931 1496 3291456
SGTC_2231 micatex 6.853 µM 0.493171645851851 0.332131195114985 no 1111 0.310945655291721 1514 20737 An antifungal of unknown mechanism.
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.492541700288699 0.332318318277876 no 1112 0.311168225147778 1527 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1182 1222-0449 220 µM 0.489850158391385 0.333118301978952 no 1113 0.312119967178257 1518 658318
SGTC_1807 st050092 58.9 µM 0.489476106406932 0.333229538439778 no 1114 0.312252333236687 1471 5008496
SGTC_1178 0988-0033 191 µM 0.489150255926536 0.333326452581318 no 1115 0.312367661946338 1521 5392207
SGTC_401 neomycin 50 µM 0.489030257724732 0.333362145136879 no 1116 0.312410137707362 1490 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2695 st077686 51.995 µM 0.488093284549352 0.333640892572136 no 1117 0.312741883765286 1453 2876092
SGTC_1774 st048371 48.465 µM 0.487397735686204 0.333847876225567 no 1118 0.312988248937504 1458 4242727
SGTC_1669 st015249 58.4 µM 0.486918974300625 0.333990376953901 no 1119 0.313157875978451 1562 722793
SGTC_1810 st050138 53 µM 0.485483707683505 0.334417719664326 no 1120 0.313666633456797 1517 3444541
SGTC_325 2810-4341 181 µM 0.48520924116202 0.334499465021658 no 1121 0.313763963738037 1605 774970
SGTC_870 0573-2213 57.6 µM 0.483910825957646 0.334886283030823 no 1122 0.314224578449288 1461 3916321
SGTC_591 4299-0174 154 µM 0.48307601973819 0.335135077324434 no 1123 0.314520880129435 1526 5509088
SGTC_356 1634-0012 32.5 µM 0.481587593671083 0.335578847027476 no 1124 0.315049470571239 1550 735457
SGTC_1805 st050013 60.3 µM 0.480441623418601 0.335920670942946 no 1125 0.315456701671075 1538 4037144
SGTC_404 fumagillin 50 µM 0.480151872318361 0.336007120403784 no 1126 0.315559702935128 1521 12015870 A methionine aminopeptidase binder.
SGTC_1827 berberine 7.24 µM 0.47712829968504 0.336909743350706 no 1127 0.316635381978648 1393 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1007 4101-0031 70 µM 0.477070850503736 0.336926902691312 no 1128 0.316655835400946 1613 1146276
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.476847982759086 0.336993473667194 no 1129 0.316735187495645 1536 2724278 An inhibitor of dopamine biosynthesis.
SGTC_693 4161-2696 114 µM 0.474065437496998 0.33782505393297 no 1130 0.317726622135412 1606 805759
SGTC_3253 9135987 49.47 µM 0.472928948968017 0.338164928422757 no 1131 0.318131935366795 1530 4182430
SGTC_1115 galangin 695.678 nM 0.471968778795086 0.33845217656242 no 1132 0.318474536880679 1564 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_200 k038-0079 37.545 µM 0.471761989153786 0.33851405284463 no 1133 0.318548342512901 1562 3436683
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.470247706623241 0.338967294252166 no 1134 0.319089026855139 1469 88881 An O-methylated flavonoid and antioxidant.
SGTC_684 1140-0066 328 µM 0.469986520394258 0.33904549375999 no 1135 0.319182324054354 1502 6813534
SGTC_2512 diallyl trisulfide 49.23 µM 0.468853002447481 0.339384950879345 no 1136 0.319587355728467 1499 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_64 000l-0018 272.079 µM 0.468112632904767 0.339606741386499 no 1137 0.319852022830446 1538 6811119
SGTC_708 3448-5400 146 µM 0.467650327334456 0.339745261199951 no 1138 0.32001733423577 1506 3462195
SGTC_1316 1272-0050 65.9 µM 0.466706748458522 0.340028051253236 no 1139 0.320354850434455 1522 7340392
SGTC_2739 tacrine 100.86 µM 0.46572169056853 0.34032336859528 no 1140 0.320707362199224 1526 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2154 5570129 200 µM 0.465400698272861 0.340419622273103 no 1141 0.320822267115614 1521 673366
SGTC_1256 0570-0116 285 µM 0.463162221003112 0.341091147281849 no 1142 0.321624046741593 1494 410638
SGTC_1030 k029-0042 36.7 µM 0.463087937791693 0.341113440287893 no 1143 0.321650667838455 1568 6080581
SGTC_1930 st074634 34.3 µM 0.462680717254052 0.341235660391438 no 1144 0.321796620949258 1483 684253 YOR116C RPO31
SGTC_2009 4012297 12.05 µM 0.461086935973383 0.341714165960773 no 1145 0.322368117063905 1516 45595307
SGTC_718 1130-0073 349 µM 0.460818174191616 0.341794882181543 no 1146 0.322464530758632 1603 6740020
SGTC_1845 st056753 3.01 µM 0.459558148078557 0.342173397504466 no 1147 0.322916702726432 1472 5375839
SGTC_1701 st028638 40.4 µM 0.454712124613701 0.34363063174034 no 1148 0.324658178484925 1633 3490878
SGTC_1132 3456-3614 2.5 µM 0.450888651135425 0.344782021368418 no 1149 0.326034901686394 1760 3125502
SGTC_1150 3909-7983 10.9 µM 0.450233058015437 0.344979589591048 no 1150 0.326271200996183 1516 23965914
SGTC_1971 st069429 63.5 µM 0.449702129093162 0.345139620242786 no 1151 0.326462617977315 1613 1246522 YGL099W LSG1
SGTC_1424 4048-1941 275 µM 0.447547466671767 0.345789354729778 no 1152 0.32723991189316 1666 X1424
SGTC_571 k831-0106 44.2 µM 0.445019413327978 0.346552263882939 no 1153 0.328152862386859 1650 4783639
SGTC_1835 st008666 49.2 µM 0.444660747672154 0.346660551561337 no 1154 0.32828246989917 1509 690455
SGTC_2046 4110841 106 µM 0.444246602947818 0.34678560496523 no 1155 0.328432151056617 1592 44119630 YMR134W ERG29
SGTC_1885 st057546 99.9 µM 0.444177815269667 0.346806377421011 no 1156 0.328457015128259 1618 702008
SGTC_1819 st053448 58.6 µM 0.443166255229704 0.347111900775193 no 1157 0.328822742440546 1593 2857616
SGTC_1703 st026983 48.3 µM 0.443088898820065 0.347135268968851 no 1158 0.328850717234277 1645 1104023
SGTC_1460 k062-0059 9.15 µM 0.439651483463545 0.34817424543511 no 1159 0.330094773330461 1519 1373085
SGTC_549 1661-1316 519 µM 0.438779298136868 0.348438049657157 no 1160 0.330410731014508 1672 2857282
SGTC_2497 7-hydroxyflavone 100 µM 0.438500613004128 0.348522357200414 no 1161 0.330511712940162 1630 5281894
SGTC_1726 st035556 14.5795 µM 0.438201782388707 0.348612767448397 no 1162 0.3306200083194 1661 5919439
SGTC_1335 1486-0900 202 µM 0.43701489837491 0.348971940273708 no 1163 0.331050271713534 1555 X1335
SGTC_2098 5376439 882.5 nM 0.436980049159705 0.348982488331105 no 1164 0.331062908456621 1679 2844116
SGTC_1091 telmisartan 47.6 µM 0.435756778566762 0.349352818144007 no 1165 0.331506602877692 1646 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1336 1486-0901 104 µM 0.433917576766586 0.349909883308746 no 1166 0.332174147754502 1603 5006114
SGTC_475 α-linolenic acid 10 µM 0.430553794630234 0.350929555223933 no 1167 0.333396421947575 1651 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3186 9110464 49.47 µM 0.429258181304038 0.351322584857077 no 1168 0.333867673156215 1618 17018021
SGTC_307 1501-1223 22.3 µM 0.428757973086241 0.35147436765623 no 1169 0.33404968321261 1589 2830329
SGTC_1987 st072290 61.9 µM 0.427177164522171 0.351954202606609 no 1170 0.334625146254117 1615 54697379
SGTC_3047 9092122 49.47 µM 0.424195123244855 0.352860006093888 no 1171 0.335711758554646 1551 17173831
SGTC_931 2812-0076 566 µM 0.421432606949244 0.353699873198016 no 1172 0.336719606579303 1582 3450959
SGTC_357 1325-0123 420 µM 0.421141261600052 0.353788490348731 no 1173 0.33682596656734 1681 1098503
SGTC_3102 9121669 49.47 µM 0.420875367999058 0.353869372875338 no 1174 0.336923046403804 1627 41905072
SGTC_741 4582-0002 126 µM 0.420403423777347 0.354012950454147 no 1175 0.33709538368825 1552 2912688
SGTC_1281 0884-0031 11.8 µM 0.419244232037507 0.354365694498716 no 1176 0.337518824465316 1569 1548255
SGTC_830 4076-0286 57.8 µM 0.417685544548006 0.35484020274307 no 1177 0.338088521297031 1632 6866659
SGTC_3036 9090181 49.47 µM 0.41536422572359 0.355547294795193 no 1178 0.33893764557162 1616 25236586
SGTC_2448 5185112 27.17 µM 0.414244861988437 0.355888439757979 no 1179 0.339347394961255 1592 5718189
SGTC_2284 7945075 39.21 µM 0.414127062938865 0.355924347721134 no 1180 0.339390527025201 1748 1245402
SGTC_524 r073-0010 27.8 µM 0.414021889424196 0.355956408199786 no 1181 0.339429038033775 1553 2772106
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.413372143240795 0.356154495600871 no 1182 0.339666990430786 1661 676296 Flavone; oxidizing agent.
SGTC_3214 9129694 49.47 µM 0.413054333735096 0.356251399977822 no 1183 0.339783403061149 1715 17158655
SGTC_2260 7964312 200 µM 0.412651455593445 0.356374256265364 no 1184 0.339930998032633 1711 231951
SGTC_1415 3966-0071 78.1 µM 0.409476890921858 0.357342849340041 no 1185 0.34109486115765 1629 2893185
SGTC_1754 st042065 16.137 µM 0.404508712571455 0.358860537156809 no 1186 0.342919336171835 1577 1126236 YIL048W NEO1
SGTC_2142 5622915 118.518 µM 0.403644359200161 0.359124809833458 no 1187 0.34323713043336 1593 5322196
SGTC_616 4092-0450 108 µM 0.403283226721989 0.359235244659691 no 1188 0.343369939806136 1652 787165
SGTC_1290 0986-0249 10.2 µM 0.401734488259293 0.359708984365646 no 1189 0.343939720008374 1632 53329
SGTC_764 1951-2361 146 µM 0.400570727879813 0.360065106043546 no 1190 0.344368100354235 1561 5438930
SGTC_1820 st053765 18.6 µM 0.399951944568121 0.360254509076594 no 1191 0.344595955940402 1594 3690829
SGTC_2683 piperine 63.03 µM 0.399947367116156 0.360255910314146 no 1192 0.344597641713224 1619 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_595 3909-8003 73.7 µM 0.399287179627907 0.360458024822183 no 1193 0.344840806254 1651 699517
SGTC_1773 st048542 73.5835 µM 0.398993715485788 0.360547880551839 no 1194 0.344948917459053 1544 3237138
SGTC_586 0957-0265 8.15 µM 0.397802092290288 0.360912822506767 no 1195 0.345388037430229 1661 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2558 carylophyllene oxide 100 µM 0.39626308309159 0.361384340973454 no 1196 0.34595547915514 1673 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_3324 9138759 60.749 µM 0.395124938683497 0.361733178837368 no 1197 0.346375342399326 1652 45595710
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.394704970594622 0.361861926847402 no 1198 0.346530317006593 1645 97141
SGTC_1506 4226-2149 212 µM 0.394265506711064 0.361996668350171 no 1199 0.34669251336591 1673 991114
SGTC_640 3381-0960 37.1 µM 0.393781933645658 0.362144953683746 no 1200 0.346871021922063 1714 1745025
SGTC_3123 9126162 49.47 µM 0.392159553200372 0.362642599823286 no 1201 0.34747016362252 1645 25239884
SGTC_1112 tnp00069 1.16933 µM 0.391564302146754 0.362825244342348 no 1202 0.34769008427803 1728 145826
SGTC_2994 9053520 71.4286 µM 0.390456758782187 0.363165161677776 no 1203 0.348099412143734 1743 4647384
SGTC_81 0411-0046 9.971 µM 0.389997841647628 0.363306040038168 no 1204 0.348269071466977 1601 12925265
SGTC_228 caffeine 993.056 µM 0.388742791038517 0.363691409804948 no 1205 0.348733212272434 1708 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1488 4013-0813 75.9 µM 0.388078524863391 0.363895432014624 no 1206 0.348978961832015 1625 2910057
SGTC_1086 cerivastatin 2.18 µM 0.387886206020334 0.363954507884688 no 1207 0.349050123260947 1686 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3255 9139072 49.47 µM 0.387775181937543 0.363988613369765 no 1208 0.349091206584354 1652 17646060
SGTC_263 alizarin 107.927 µM 0.38518319050142 0.364785152817239 no 1209 0.350050848203607 1684 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_109 0132-0036 33.701 µM 0.385167866315521 0.364789863800523 no 1210 0.35005652458375 1644 67274 A color developer.
SGTC_2549 cedrol 20.94 µM 0.383840689369336 0.365197943823431 no 1211 0.350548264033666 1720 6708665 A sedative which affects the nervous system.
SGTC_449 xestospongin c 11.1929 µM 0.382852495169546 0.365501892721581 no 1212 0.350914567951017 1709 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_110 0850-0284 111.64 µM 0.382847310910942 0.365503487519429 no 1213 0.350916490018241 1600 3906265
SGTC_2396 5342950 42.78 µM 0.379295085537768 0.366596779462688 no 1214 0.352234374335888 1639 1886677
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.377639917410299 0.367106572070949 no 1215 0.352849053479774 1607 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1455 4262-0120 131 µM 0.376988910503059 0.367307146799952 no 1216 0.353090923051368 1741 1529587
SGTC_3182 9108849 49.47 µM 0.376176855978754 0.367557390929491 no 1217 0.353392710089027 1676 17133045
SGTC_2374 9071832 200 µM 0.37585526134737 0.367656509642745 no 1218 0.353512251072274 1650 17381698
SGTC_725 1497-0963 19 µM 0.375789244038652 0.367676857934819 no 1219 0.353536792368155 1801 3549977
SGTC_2740 felodipine 17.08 µM 0.374608836819464 0.368040753512148 no 1220 0.3539757000135 1775 3333 L-type calcium channel blocker
SGTC_3345 9148410 3.559 µM 0.368242465306654 0.370005411196929 no 1221 0.356346224397934 1765 4903596
SGTC_1347 1493-0251 600 nM 0.366596928830785 0.370513777175144 no 1222 0.356959849701744 1786 3986378
SGTC_2948 9070189 9.45 µM 0.364342271763945 0.371210689775184 no 1223 0.357801218790396 1796 6473636 YDL196W YDL196W
SGTC_3199 9111318 49.47 µM 0.363304992886727 0.371531453852828 no 1224 0.358188532006326 1749 8548020
SGTC_1600 coumarin 106 71.1 µM 0.362380240729002 0.37181749585005 no 1225 0.358533951574437 1713 100336 A hepatotoxic, DNA x-linker.
SGTC_2799 7812892 81.82 µM 0.361560918325866 0.37207098571966 no 1226 0.358840087055727 1788 20205235
SGTC_497 capsazepine 133 µM 0.35984418469531 0.372602305046791 no 1227 0.359481829410739 1599 2733484 A calcium channel blocker.
SGTC_2338 7999974 200 µM 0.35847761595386 0.373025423745602 no 1228 0.359992958117959 1869 315925
SGTC_3237 9133362 49.47 µM 0.358427406483512 0.373040972584621 no 1229 0.36001174241067 1742 43845137
SGTC_2281 7943571 200 µM 0.358277652261856 0.373087349611364 no 1230 0.360067770245977 1851 1244024
SGTC_2431 5490079 200 µM 0.35752442601987 0.373320642319336 no 1231 0.360349621793784 1650 5722345
SGTC_816 0325-0417 81.3 µM 0.356569089539586 0.373616600343923 no 1232 0.360707210640592 1665 68101
SGTC_1188 1403-0014 4.57 µM 0.356073024981967 0.37377030785171 no 1233 0.360892939002176 1687 9614867
SGTC_1446 4239-0190 62 µM 0.355993451906068 0.373794965744101 no 1234 0.360922734503692 1669 1340085
SGTC_1046 2001-0062 216 µM 0.355845002387554 0.373840968265359 no 1235 0.360978322493965 1656 739778
SGTC_2786 7743617 45.45 µM 0.353726324787521 0.374497713695844 no 1236 0.361771996074619 1600 583674
SGTC_2730 imipramine 71.33 µM 0.351633388981278 0.375146837405576 no 1237 0.362556610812499 1779 3696 A tricyclic antidepressant.
SGTC_486 niguldipine 82 µM 0.351335738079302 0.375239182560888 no 1238 0.362668243297773 1716 1236 A calcium channel blocker.
SGTC_1897 st060201 15 µM 0.350558556014484 0.375480334287187 no 1239 0.362959776568421 1660 611878
SGTC_196 k015-0023 18.111 µM 0.34994914135251 0.375669463531197 no 1240 0.363188433210756 1688 5211998
SGTC_3187 9109394 49.47 µM 0.348977260914995 0.375971144288145 no 1241 0.363553190422151 1641 17098090
SGTC_2112 5488546 200 µM 0.348607330378247 0.376085994110438 no 1242 0.363692061871242 1687 600757
SGTC_3140 9094243 49.47 µM 0.348191303391369 0.376215168296376 no 1243 0.363848259264521 1806 19291112
SGTC_438 sphingosine 6.67 µM 0.347800672625058 0.37633646971374 no 1244 0.363994942241614 1535 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1937 st074714 47.2 µM 0.347314028926536 0.376487602829582 no 1245 0.364177706228656 1616 17250970
SGTC_414 piperonyl butoxide 100 µM 0.347135910196688 0.37654292450124 no 1246 0.364244608252967 1666 5794 A potent inhibitor of cytochrome P450.
SGTC_3068 9116768 49.47 µM 0.344996485684338 0.377207603504742 no 1247 0.365048506372886 1703 41904888
SGTC_2235 salicylic acid 500 µM 0.342484352091512 0.377988540721981 no 1248 0.365993209007074 1757 338 A COX inhibitor and kinase inhibitor.
SGTC_2702 st077768 96.8 µM 0.342018734543008 0.378133340334198 no 1249 0.366168396709633 1680 6484119
SGTC_1523 st012844 44.7 µM 0.341858510299844 0.378183171471912 no 1250 0.3662286872255 1714 4274103
SGTC_306 1672-3436 11.6 µM 0.341406355331934 0.378323806538136 no 1251 0.366398845676921 1772 6797378
SGTC_2887 9044784 58.44 µM 0.340851895581926 0.378496283759 no 1252 0.366607540108363 1723 6465546
SGTC_561 1550-0330 72.9 µM 0.340414815513126 0.378632264445738 no 1253 0.366772081526486 1688 6812934
SGTC_2624 nerol 100 µM 0.340381498800774 0.378642630278589 no 1254 0.36678462480766 1805 637566 A natural product oil.
SGTC_2961 9083290 32.55 µM 0.337694028467122 0.379479070222818 no 1255 0.367796887639717 1728 17741490
SGTC_1442 4112-3290 3 µM 0.337299128032221 0.379602025463077 no 1256 0.367945708478839 1729 704353
SGTC_3162 9099653 49.47 µM 0.335839963387172 0.380056452946242 no 1257 0.368495776116709 1796 25237511
SGTC_2635 hydroquinidine 100 µM 0.335441737415886 0.380180501214176 no 1258 0.368645943968727 1716 442912 An experimental heart treatment.
SGTC_1200 1643-0193 18.4 µM 0.33531798166405 0.380219053914726 no 1259 0.368692615367029 1815 5403974
SGTC_20 0481-0013 4.944 µM 0.330447952709594 0.381737118700571 no 1260 0.370530756736317 1692 182045
SGTC_511 blebbistatin 171 µM 0.328306180701982 0.382405320615856 no 1261 0.371340085709922 1822 3476986 A myosin inhibitor.
SGTC_2939 9044578 71.43 µM 0.327945884458607 0.382517762312532 no 1262 0.371476289838607 1691 2653634
SGTC_1259 0671-0132 43 µM 0.323101449864481 0.384030577826522 no 1263 0.373309206135573 1729 X1259
SGTC_3122 9126309 49.47 µM 0.320449081623325 0.384859607742049 no 1264 0.374313961868355 1886 17591206
SGTC_3252 9135871 49.47 µM 0.320401971344496 0.384874337403576 no 1265 0.374331815669219 1803 17682838
SGTC_1302 1159-0335 255 µM 0.32010732485749 0.384966466354424 no 1266 0.374443486578092 1704 649284
SGTC_1653 st012112 65 µM 0.315414779780795 0.38643458570675 no 1267 0.376223373249093 1834 720429
SGTC_1374 2889-5571 141 µM 0.31375701268978 0.386953628202341 no 1268 0.376852797850237 1733 2853281
SGTC_1482 3346-2049 8.48 µM 0.313387984652666 0.387069197457478 no 1269 0.376992955832091 1829 3826804
SGTC_2671 danthron 100 µM 0.312045457392214 0.387489723824876 no 1270 0.377502988438164 1765 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_93 0109-0045 59.227 µM 0.31047775312044 0.387980950577722 no 1271 0.378098837308588 1869 88733
SGTC_747 3448-8087 38.7 µM 0.309867364463904 0.388172259193688 no 1272 0.378330910741044 1727 5168703
SGTC_1777 st045864 34.765 µM 0.309731495650533 0.38821484702584 no 1273 0.378382574855805 1767 4691462
SGTC_83 0170-0301 39.027 µM 0.309339823985061 0.388337623317204 no 1274 0.378531520166969 1817 3089716
SGTC_971 1315-0384 26.7 µM 0.308805258976487 0.388505210016478 no 1275 0.378734834228808 1708 6769120
SGTC_2634 4'-methoxyflavone 100 µM 0.30858171255519 0.388575298214257 no 1276 0.378819866829871 1747 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1006 4099-6547 255 µM 0.307775738122413 0.388828024356941 no 1277 0.379126492104984 1826 3146833
SGTC_422 cantharidin 155 µM 0.305036724378698 0.389687236893041 no 1278 0.380169091176006 1680 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_846 0335-0850 148 µM 0.30121485878137 0.390887034374264 no 1279 0.381625330010514 1810 6819598
SGTC_3049 9092223 49.47 µM 0.300301198875361 0.39117401380802 no 1280 0.381973709421504 1810 8623917
SGTC_1196 1588-0294 184 µM 0.298925265744428 0.391606304458873 no 1281 0.382498534367668 1731 6144269
SGTC_1440 4100-1550 40 µM 0.297599204607798 0.392023053034946 no 1282 0.383004540857681 1841 742806
SGTC_108 0509-0257 621.132 µM 0.296289582343148 0.392434756892788 no 1283 0.383504470534539 1865 536624
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.295699926796901 0.392620165305758 no 1284 0.383729626547464 1939 5024745
SGTC_2077 5212015 200 µM 0.295575602864661 0.392659260228796 no 1285 0.383777103820698 1773 780900
SGTC_2383 9036125 200 µM 0.295200111369155 0.392777343916674 no 1286 0.383920508461584 1811 79580
SGTC_1661 st013063 9.66 µM 0.29304991682412 0.393453721830129 no 1287 0.384741998763404 1777 721395
SGTC_713 1488-1073 324 µM 0.29301191758504 0.393465677993987 no 1288 0.384756521188932 1911 3312542
SGTC_245 methotrexate 289.6 µM 0.291795637153697 0.393848424143812 no 1289 0.385221440599395 1845 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1128 3448-9350 235 µM 0.29138545979502 0.393977524268992 no 1290 0.385378266861954 1752 619386
SGTC_2302 7771753 200 µM 0.288965346628713 0.394739472751336 no 1291 0.386303948101825 1720 2203047
SGTC_2601 securinine 100 µM 0.288574119527316 0.39486268459851 no 1292 0.386453651455669 1745 442872 A GABA receptor antagonist.
SGTC_1848 st056003 16.4 µM 0.287685959252802 0.395142438050586 no 1293 0.386793569381169 1981 146492
SGTC_2401 5128683 200 µM 0.287299777768034 0.395264094682504 no 1294 0.386941396402162 1714 708373
SGTC_716 1683-5115 658 µM 0.285882923877214 0.395710525733977 no 1295 0.387483896470607 1924 723597
SGTC_116 0155-0182 31.788 µM 0.284784674815784 0.39605666300184 no 1296 0.387904556998077 1785 771486
SGTC_2986 9022445 71.43 µM 0.284584488126213 0.396119765065875 no 1297 0.387981248368312 1928 6459286
SGTC_613 3914-0030 117 µM 0.28330955374135 0.396521708692084 no 1298 0.38846977717655 1832 1145395
SGTC_3096 9117468 49.47 µM 0.282864205875345 0.396662137732535 no 1299 0.38864046700941 1874 41316311
SGTC_1866 st057638 64 µM 0.281438812046566 0.397111689183042 no 1300 0.389186926444139 1794 688802
SGTC_2850 9015429 58.44 µM 0.281115505515143 0.397213675080239 no 1301 0.389310904419236 1766 6457570
SGTC_3356 9151811 4.48 µM 0.280217564509468 0.397496964229313 no 1302 0.389655295872112 1787 1859254 YPR165W RHO1
SGTC_2594 a-mangostin 100 µM 0.27990511316083 0.397595551407977 no 1303 0.389775152116233 1920 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1003 4049-0218 100 µM 0.277936145383581 0.398216966303251 no 1304 0.390530688298652 1888 295161
SGTC_453 enantio-paf c16 10 µM 0.277844355760796 0.398245941824061 no 1305 0.390565920103464 1848 13871343 A lipid and platelet activating factor
SGTC_1749 st037932 54.2 µM 0.277398289144551 0.398386761071044 no 1306 0.390737147583396 1795 594497
SGTC_2937 9044753 11.33 µM 0.27607812569208 0.398803602354847 no 1307 0.39124403058838 1802 6465530 YGL099W LSG1
SGTC_2975 9084847 53.72 µM 0.275629269984953 0.398945354757685 no 1308 0.391416412994241 1786 27211724
SGTC_223 busulfan 5 mM 0.274098776387945 0.399428797594985 no 1309 0.392004357070945 1894 2478 A DNA alkylator.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.272608779400335 0.399899596814932 no 1310 0.392576981247655 1834 364106
SGTC_1439 4092-1168 46 µM 0.268526493661203 0.401190233732455 no 1311 0.394147042231795 1856 2886240
SGTC_765 1319-0117 244 µM 0.266663791710975 0.401779496462608 no 1312 0.394864017342155 1775 3487746 YGL099W LSG1
SGTC_3163 9099914 49.47 µM 0.266075882145302 0.401965527137395 no 1313 0.395090384470869 1918 16268368
SGTC_1384 3089-0840 101 µM 0.264809624536615 0.402366281087577 no 1314 0.395578061100215 1939 1069836
SGTC_289 k017-0060 526 µM 0.262359945376249 0.403141863462487 no 1315 0.396521975142132 1851 5512909
SGTC_2451 5856223 45.7 µM 0.261834020015569 0.403308424235536 no 1316 0.396724704797539 1799 2179896
SGTC_77 0828-0286 12.516 µM 0.261663513103146 0.403362427610218 no 1317 0.39679043648373 1944 745345
SGTC_1163 k060-0048 49.9 µM 0.259550620701977 0.404031780763002 no 1318 0.397605215039632 1822 6809982
SGTC_2551 apiole 73.87 µM 0.259026272726147 0.404197935041844 no 1319 0.397807484697427 1905 10659 A possible DNA adduct former.
SGTC_2099 5377090 177.372 µM 0.258807226105496 0.404267351192109 no 1320 0.397891991083827 1821 2243829
SGTC_2524 avocatin b 10.57 µM 0.25801333404589 0.404518961829739 no 1321 0.398198308236786 1947 6710748
SGTC_3353 9151644 39.2805 µM 0.258001992381145 0.404522556664589 no 1322 0.398202684786074 1853 4909158
SGTC_1573 oleylamine 1.06 µM 0.256657477753056 0.404948768775093 no 1323 0.398721599974193 1807 5356789 An amine of the fatty acid oleic acid.
SGTC_2656 pseudo-anisatin 100 µM 0.255622180549279 0.405277035621626 no 1324 0.399121294846553 1876 6708809 A neurotoxin.
SGTC_1863 st057641 20.1 µM 0.255617468545846 0.405278529832581 no 1325 0.399123114241309 2012 3921635
SGTC_1349 flufenamic acid 69 µM 0.255533394518628 0.405305190557209 no 1326 0.399155577201503 1837 3371 A non-steroidal anti-inflammatory.
SGTC_2947 9072639 7.68 µM 0.255029614453071 0.405464953513741 no 1327 0.399350113141723 1801 16488146
SGTC_2826 7992541 19.48 µM 0.254447078914147 0.405649711701951 no 1328 0.399575091865231 1921 2985066
SGTC_2429 5902844 64.44 µM 0.253984229386386 0.405796525013624 no 1329 0.399753870911729 1979 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2354 9060492 162 µM 0.252788162970454 0.406175971985883 no 1330 0.400215957638382 1948 6471895
SGTC_965 1291-5240 308 µM 0.251726524855456 0.406512846005066 no 1331 0.400626226590236 1940 2834598
SGTC_2956 9076196 2.52 µM 0.250946168742421 0.406760509084594 no 1332 0.400927864352301 1964 16423868
SGTC_583 1488-1091 88.9 µM 0.250603985965316 0.406869120041058 no 1333 0.401060149846623 2018 4303273
SGTC_1677 st019204 53.9 µM 0.250121706372421 0.407022210765084 no 1334 0.401246615059296 1798 3945625
SGTC_380 3970-0968 6 µM 0.249212933812179 0.407310722371567 no 1335 0.401598037629574 1845 2891601
SGTC_297 0986-0032 24 µM 0.248805345251579 0.407440137464286 no 1336 0.401755678097433 1871 2847425
SGTC_1753 st043925 64 µM 0.247090237338671 0.407984818862017 no 1337 0.402419194502664 1989 670181
SGTC_1060 3448-7350 82 µM 0.246842300369311 0.40806357305279 no 1338 0.402515136119976 1971 570178
SGTC_286 k060-0067 22.9 µM 0.245378829256213 0.408528502581634 no 1339 0.403081559911106 1865 5985051
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.243993672130747 0.408968671207912 no 1340 0.403617860375105 2009 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1481 3346-2004 36 µM 0.243427786470221 0.409148528723461 no 1341 0.403837010290115 1954 2770522
SGTC_1191 1487-1166 10.6 µM 0.242505679101154 0.409441646455638 no 1342 0.404194178442498 1945 3955771
SGTC_1014 4130-3005 69.3 µM 0.241831509344942 0.409655982303188 no 1343 0.404455361251029 1830 743608
SGTC_300 r073-0011 5.04 µM 0.241753704028019 0.409680720347167 no 1344 0.404485506863944 2010 2735780
SGTC_2733 amorolfine 100 µM 0.24052126432761 0.410072619964815 no 1345 0.404963090235193 2036 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_445 e6 berbamine 66 µM 0.239342789042765 0.410447443639479 no 1346 0.405419894262201 1873 6610268 A calcium/calmodulin antagonist.
SGTC_667 1498-1044 59 µM 0.239127006415278 0.410516083935389 no 1347 0.40550355052917 1884 6739982
SGTC_413 propylparaben 100 µM 0.238710285847666 0.410648650199225 no 1348 0.405665120175409 1847 7175 A pharmaceutical preservative.
SGTC_43 0570-0105 72.5 µM 0.238399011157724 0.410747678905004 no 1349 0.405785817151245 1876 1114046 YDL195W SEC31
SGTC_1459 k035-0031 35.7 µM 0.237969312502731 0.410884392272567 no 1350 0.405952447815631 1791 3877128 YMR208W ERG12
SGTC_3104 9120930 49.47 µM 0.236412047988976 0.411379943751912 no 1351 0.406556474095223 1911 17014836
SGTC_1575 cyproterone acetate 48 µM 0.235939858756397 0.411530231413053 no 1352 0.406739669201472 1828 9880 An androgen receptor antagonist and liver toxin.
SGTC_1950 st077106 7.18 µM 0.232918314618124 0.412492230228773 no 1353 0.407912418258003 1852 13831864
SGTC_450 aminopyrene 156 nM 0.232586273555862 0.412597977594133 no 1354 0.408041343573881 1979 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3082 9117008 49.47 µM 0.230692469200739 0.41320123134939 no 1355 0.408776862224463 1878 41448529
SGTC_1798 st045719 60.953 µM 0.230470983961889 0.413271796827482 no 1356 0.408862904043338 1982 3980186
SGTC_53 0973-0023 39.979 µM 0.230136829213024 0.413378264255898 no 1357 0.408992723634109 2055 674768
SGTC_1057 3448-5381 134 µM 0.229861333287654 0.413466046769074 no 1358 0.409099761698552 1996 5497911
SGTC_720 r052-1644 49.9 µM 0.227128866817091 0.414336938446998 no 1359 0.410161769041383 1899 1422863 YOR257W CDC31
SGTC_996 3970-0799 1.8 µM 0.226543315592083 0.414523620290344 no 1360 0.410389436902109 2015 6615648 YGL040C HEM2
SGTC_1301 naphtanilide LB 4.81 µM 0.226341240283904 0.414588049182056 no 1361 0.410468012709123 2002 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2977 9011197 71.43 µM 0.225927351763954 0.414720018931701 no 1362 0.410628962066039 1981 2704722
SGTC_2178 5812956 200 µM 0.220854239129109 0.41633837566354 no 1363 0.412602964719781 1983 5403383
SGTC_545 4218-0007 221 µM 0.219368956049434 0.416812460695071 no 1364 0.413181325279973 1917 2840508
SGTC_751 0833-0568 350 µM 0.218263841733754 0.417165278844198 no 1365 0.413611772696736 1930 6954252
SGTC_349 k015-0014 24 µM 0.215930231299286 0.417910524795237 no 1366 0.414521065882619 1866 2196908
SGTC_2877 9040724 71.43 µM 0.214726011033357 0.418295211901118 no 1367 0.414990470848961 2078 6463895
SGTC_678 1218-2179 85.9 µM 0.21435230810678 0.418414606882516 no 1368 0.415136164932257 1973 6820081 YOR116C RPO31
SGTC_2276 7947513 42.08 µM 0.214050386283069 0.418511073888306 no 1369 0.415253882525286 1767 2105100
SGTC_3005 9076496 71.4286 µM 0.213873227987013 0.418567679996317 no 1370 0.41532295907453 2048 21368410
SGTC_2460 5552655 174.22 µM 0.212339875700156 0.41905769129443 no 1371 0.415920944168271 1889 5401989
SGTC_3263 9137018 49.47 µM 0.20894376922644 0.420143426458898 no 1372 0.41724606763762 1843 43844957
SGTC_3313 9133968 57.047 µM 0.208617817282586 0.420247665395458 no 1373 0.41737330021273 1969 1494643
SGTC_2148 5546263 113.568 µM 0.208090814302584 0.420416211978819 no 1374 0.417579029650874 1937 792097
SGTC_2155 5570423 76 µM 0.207993860243441 0.420447221506443 no 1375 0.41761688067014 1912 797402
SGTC_820 1582-0060 59.9 µM 0.206589947417355 0.420896300481791 no 1376 0.418165055854023 1920 3848840
SGTC_2938 9059746 27.26 µM 0.20422869397286 0.421651842306955 no 1377 0.41908739466255 1987 6471769
SGTC_975 1335-0046 28.5 µM 0.203733104206797 0.421810455315913 no 1378 0.419281035647846 1858 16486740
SGTC_1039 k821-0043 94 µM 0.203678414698921 0.421827959415829 no 1379 0.41930240558925 2032 15992768
SGTC_551 k048-0028 34.9 µM 0.203489706771219 0.42188835906821 no 1380 0.419376145095294 2015 6836383
SGTC_177 1327-0068 8.361 µM 0.203480880313474 0.421891184193134 no 1381 0.419379594191085 2022 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_13 0199-0087 65 µM 0.202884183592692 0.422082180970756 no 1382 0.419612778428784 2040 4589825
SGTC_1058 3448-5425 97.3 µM 0.202612061286154 0.422169290743966 no 1383 0.419719130996448 2045 7279705
SGTC_2847 9005661 71.43 µM 0.20241699191079 0.422231737247896 no 1384 0.419795372857152 2065 2991449
SGTC_2347 9049783 174.81 µM 0.202132192611834 0.422322912017229 no 1385 0.419906690601783 2006 6467988 YPL169C MEX67
SGTC_36 0335-0881 14.2 µM 0.200679607707339 0.422788002724282 no 1386 0.420474553012767 1955 23828853
SGTC_2305 7443522 69.23 µM 0.199686118901307 0.423106161417956 no 1387 0.420863035321988 1981 5415886
SGTC_1289 0976-0073 69.1 µM 0.197063014067896 0.423946435143051 no 1388 0.421889113175148 1999 3391136
SGTC_222 nsc-310342 10.666 µM 0.196652528387894 0.424077959694321 no 1389 0.422049730715472 2067 432556
SGTC_706 4262-0057 46.9 µM 0.196323512149602 0.424183386562419 no 1390 0.422178479718682 1947 883298
SGTC_126 0417-1624 672.48 µM 0.196100919982325 0.424254714979835 no 1391 0.422265588099401 2089 41912 YDL195W SEC31
SGTC_3283 9109332 35.8195 µM 0.194343716384277 0.424817887981316 no 1392 0.422953378695855 2004 17027281
SGTC_2404 5161160 200 µM 0.192798795154036 0.425313152620962 no 1393 0.42355827355713 1962 2831543
SGTC_3133 9127736 49.47 µM 0.192284829510477 0.42547794383212 no 1394 0.423759550483574 2116 27243420
SGTC_1697 st025554 27.742 µM 0.191105913310512 0.425855985213939 no 1395 0.424221307435282 1955 1269519
SGTC_523 1934-0222 13.7 µM 0.189611288530258 0.426335362356134 no 1396 0.424806870360472 1891 1361595
SGTC_1024 4507-0395 26 µM 0.188947617299901 0.426548259297082 no 1397 0.425066936240932 1964 4201836
SGTC_3223 9129970 49.47 µM 0.188487657680264 0.426695820812151 no 1398 0.425247194931177 1976 17248386
SGTC_1073 triclabendazole 3.09 µM 0.188389877335938 0.426727191444975 no 1399 0.425285517173243 1975 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_218 alverine citrate 93.75 µM 0.188088667869451 0.426823830666247 no 1400 0.425403572144718 2063 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2319 6033012 152.6 µM 0.186844791011641 0.427222959176969 no 1401 0.425891163562626 1954 847246
SGTC_2715 st079500 56.4 µM 0.184182554738763 0.42807745310695 no 1402 0.4269351223301 1953 28246688
SGTC_572 0960-0087 17.7 µM 0.182757833993036 0.428534882404397 no 1403 0.427494017449956 1961 6796365
SGTC_2163 5671233 125 µM 0.182566221464425 0.428596409999137 no 1404 0.427569195102256 2064 701023
SGTC_1167 k781-0610 148 µM 0.182108579598829 0.428743367760723 no 1405 0.427748757886538 1977 4525169
SGTC_1984 st072354 53.1 µM 0.18026697969112 0.429334841211341 no 1406 0.428471488684288 1993 5762938
SGTC_962 1254-0300 21.5 µM 0.178372915416134 0.429943330358895 no 1407 0.429215059278284 1986 7340576
SGTC_178 4092-0806 87.505 µM 0.177403264932805 0.430254905832524 no 1408 0.429595821474233 2075 2169044
SGTC_789 1309-1135 70.6 µM 0.177199555376621 0.430320368864735 no 1409 0.429675822447886 2092 3092424
SGTC_2184 6075246 200 µM 0.177005692619616 0.430382669359902 no 1410 0.429751959060889 2010 2267320
SGTC_600 1495-0418 41.6 µM 0.173870346734206 0.431390495990675 no 1411 0.430983678755605 2004 5377768
SGTC_3014 9081533 49.47 µM 0.173347080721941 0.431558738478959 no 1412 0.431189309370043 2112 21367265
SGTC_1223 0764-0573 147 µM 0.172523417676472 0.43182359091282 no 1413 0.43151302636445 2026 1609797
SGTC_907 3448-6986 75.5 µM 0.170689269181623 0.432413479277848 no 1414 0.43223405047668 2091 590582
SGTC_1170 0310-0127 64.8 µM 0.170039330435245 0.432622545091664 no 1415 0.432489602901676 2025 774975
SGTC_433 pimozide 108 µM 0.169713183643094 0.432727463850756 no 1416 0.43261785271825 1858 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2421 5690543 90.72 µM 0.169106709847615 0.432922574121521 no 1417 0.432856353624043 1999 3397993
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.16799578166745 0.433280016112724 no 1418 0.433293298829317 2061 16725076
SGTC_2204 7233102 200 µM 0.167664253415368 0.43338669616987 no 1419 0.433423709833773 2055 2172480
SGTC_1341 1486-1360 280 µM 0.167351036759939 0.433487488331029 no 1420 0.433546924390355 1958 3976547
SGTC_2438 5259590 200 µM 0.166519376209031 0.433755135126212 no 1421 0.433874118016018 2100 1201127
SGTC_366 0181-0206 4.31 µM 0.166102591161243 0.433889277224879 no 1422 0.43403810751646 2132 274874
SGTC_6 0844-0013 19.835 µM 0.163894764167661 0.434599992085298 no 1423 0.434906994477437 2120 1584900
SGTC_886 0866-0150 153 µM 0.163805302062789 0.434628795030873 no 1424 0.434942208810047 2132 271463
SGTC_2369 9071472 200 µM 0.162868038317352 0.434930574429331 no 1425 0.435311168249743 2029 17296037
SGTC_2480 5767542 37.17 µM 0.161603986296591 0.435337632853741 no 1426 0.43580885898454 2060 2867358
SGTC_3256 9138902 49.47 µM 0.159157783455674 0.436125569595612 no 1427 0.436772281871321 2127 17228773
SGTC_1916 st067606 49.2 µM 0.158600128653815 0.436305229186471 no 1428 0.436991963713805 2087 19590279
SGTC_2331 7980721 200 µM 0.156927361404573 0.436844223130438 no 1429 0.437651047865898 2099 2981221
SGTC_351 caspofungin 25 nM 0.154385863175519 0.437663361015757 no 1430 0.438652749787326 2054 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1445 4239-0156 97.7 µM 0.153573231841591 0.437925332804041 no 1431 0.438973122207556 2129 4008346
SGTC_476 mead acid 10 µM 0.152681651880799 0.438212786931085 no 1432 0.439324665389233 2011 5312531 An omega 9 fatty acid.
SGTC_1619 st003326 88.7 µM 0.150678074321773 0.438858878724942 no 1433 0.440114834948203 2143 2849032
SGTC_1849 st056239 19.2 µM 0.149674323925064 0.439182618555815 no 1434 0.440510783245702 1931 5393181
SGTC_2047 4141938 200 µM 0.147856198499601 0.439769122381625 no 1435 0.441228128351495 2037 3807862
SGTC_653 0203-0016 55.2 µM 0.147338425460253 0.439936173533205 no 1436 0.44143245214751 2078 295302
SGTC_2642 cholecalciferol 100 µM 0.146541566695429 0.440193288092771 no 1437 0.441746939296714 2138 9821465 A vitamin D precursor, similar to steriods.
SGTC_1868 st057644 42.7 µM 0.146512525507171 0.440202659003602 no 1438 0.441758401345658 2125 688665
SGTC_2495 cafestol 54.53 µM 0.143409998152949 0.441203963747097 no 1439 0.442983193604906 2079 16667697 An anti-infammatory.
SGTC_652 0437-0092 114 µM 0.143185201198566 0.441276529042053 no 1440 0.443071958560998 2100 3091274
SGTC_806 3966-4455 5.86 µM 0.142275044045279 0.44157035128881 no 1441 0.443431378973773 1986 714982
SGTC_885 0865-0106 16.8 µM 0.141873336710008 0.441700043034519 no 1442 0.443590027737285 2110 2793380
SGTC_3210 9128157 49.47 µM 0.141604477339077 0.441786848131375 no 1443 0.443696215084778 1892 17590849
SGTC_1997 st073024 93.8 µM 0.140485618429293 0.442148117728063 no 1444 0.444138157317035 2162 686268
SGTC_1045 1348-1485 165 µM 0.140326033869453 0.442199650092206 no 1445 0.444201197888159 2160 6810614
SGTC_3179 9107801 49.47 µM 0.139314128804362 0.442526432881021 no 1446 0.444600962791887 2092 4818259
SGTC_1037 k284-1091 78.7 µM 0.13610251877687 0.443563842386117 no 1447 0.44587011818134 2161 3334711
SGTC_2781 5567276 71.43 µM 0.136081733584308 0.443570557655927 no 1448 0.445878333838722 2111 2853274
SGTC_948 3448-0295 75.3 µM 0.135963740365942 0.443608679154042 no 1449 0.445924972858501 2125 678569
SGTC_2135 5326629 150.42 µM 0.134665988126686 0.444027994045389 no 1450 0.446437982860401 2034 5020077
SGTC_2876 9059903 25.97 µM 0.134526920207522 0.44407293180979 no 1451 0.446492962658152 2168 6916095
SGTC_1071 trifluoperazine 6.31 µM 0.133905743991113 0.444273664591161 no 1452 0.446738554073807 2118 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1221 2958-7315 257 µM 0.132781414789434 0.444637027324932 no 1453 0.447183126522833 2093 4562705
SGTC_1578 josamycin 24.2 µM 0.132141805940936 0.444843758047156 no 1454 0.447436064731967 1997 5282165 A P450 substrate.
SGTC_2223 6903751 107.57 µM 0.131629376514511 0.445009393389912 no 1455 0.447638724296336 2135 5598863
SGTC_1862 st057513 3.81 µM 0.130741538539742 0.445296396786355 no 1456 0.447989885675633 2109 5393163
SGTC_510 ag-490 170 µM 0.130492339718734 0.44537695820783 no 1457 0.448088457171146 2206 5328779
SGTC_360 0957-0399 1.01 µM 0.129627280047367 0.445656633664562 no 1458 0.448430659493461 2158 6752301 YPR165W RHO1
SGTC_249 wiskostatin 11.211 µM 0.129387937490294 0.445734018356242 no 1459 0.448525345968694 2178 2775510 A n-wasp and actin depolymerizer.
SGTC_1738 st035555 74 µM 0.128065174061688 0.44616173395517 no 1460 0.449048698067063 2101 5331140
SGTC_950 1165-0508 94.1 µM 0.12674082362157 0.446590025480867 no 1461 0.449572766890005 2064 6148369
SGTC_2297 7971671 152.32 µM 0.126524210361064 0.446660083594539 no 1462 0.449658492972136 2158 909016
SGTC_2272 7805186 180 µM 0.12590484520366 0.446860410862677 no 1463 0.449903623641164 2204 2956062 YPR165W RHO1
SGTC_91 0417-1751 58.384 µM 0.123691147926664 0.447576518893749 no 1464 0.450779910383211 2193 6795624
SGTC_1462 k081-0014 26.5 µM 0.123579596076026 0.447612609299327 no 1465 0.450824074301377 2150 3270634
SGTC_37 0566-0070 1.56 µM 0.12334559374215 0.447688317557376 no 1466 0.450916718936614 2160 1626686
SGTC_1771 st048882 4.1505 µM 0.122402555725897 0.447993443911929 no 1467 0.451290107277774 2008 4580403
SGTC_1121 fusaric acid 630.51 nM 0.122036076149089 0.448112029181164 no 1468 0.451435223575687 2029 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1706 st031321 9.9705 µM 0.121951652979727 0.448139347443554 no 1469 0.4514686538564 2185 6103185
SGTC_918 glabranin 770.725 nM 0.121666654567493 0.448231571115855 no 1470 0.451581511398911 2111 124049 Also referred to as licorice root.
SGTC_673 1082-0474 110 µM 0.120749808855796 0.448528275507133 no 1471 0.451944602917328 2140 3098046
SGTC_3282 9108498 15.4605 µM 0.118670208227139 0.449201370490477 no 1472 0.452768320057852 2080 16459645
SGTC_2848 9016370 25.97 µM 0.118480149852457 0.449262893150996 no 1473 0.452843611214695 2198 7894410
SGTC_2511 berberine 10.47 µM 0.116575711754476 0.449879434531703 no 1474 0.453598142839967 2112 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3304 9125678 46.087 µM 0.115848784335744 0.450114801464967 no 1475 0.453886193232137 2121 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_810 3825-7150 143 µM 0.115498711957456 0.450228155307912 no 1476 0.454024920677291 2207 22330411 YGL099W LSG1
SGTC_532 1548-0774 215 µM 0.115392778404229 0.450262457516257 no 1477 0.454066901362961 2204 5932993
SGTC_987 1497-1013 404 µM 0.114768334512507 0.450464665436114 no 1478 0.454314374283469 2190 1676435
SGTC_1147 3809-1045 12.3 µM 0.114698134585261 0.450487398437651 no 1479 0.454342196278156 2060 325925
SGTC_621 3584-0052 32.1 µM 0.113194600007036 0.450974330324427 no 1480 0.454938138361751 2203 2273927
SGTC_797 k781-0471 270 µM 0.113050440222185 0.451021021529995 no 1481 0.454995282991324 2142 23738129
SGTC_1268 0828-0275 2.46 µM 0.111573919252506 0.451499283569085 no 1482 0.455580626147855 2163 745337
SGTC_138 0850-0259 40.9225 µM 0.11011968912698 0.451970394173852 no 1483 0.456157226726634 2215 6813004
SGTC_1995 st072814 61.1 µM 0.109962196477818 0.452021419370148 no 1484 0.456219677945036 2052 5769371
SGTC_2012 4023501 200 µM 0.10783095001608 0.452711988032363 no 1485 0.457064895730814 2104 3477460
SGTC_3320 9137005 35.139 µM 0.10701239396327 0.452977255540857 no 1486 0.457389573628947 2055 4908713
SGTC_1346 1488-2224 62.4 µM 0.1034419684862 0.454134558682817 no 1487 0.458806102371911 2232 3722427
SGTC_1287 0971-0001 34.6 µM 0.102671376150473 0.4543843867804 no 1488 0.459111896040772 2155 4665869
SGTC_2111 5486399 200 µM 0.101860885217034 0.454647169581275 no 1489 0.45943354874774 2210 689674
SGTC_149 3970-0822 46.1 µM 0.101543117758078 0.454750203699235 no 1490 0.459559665699902 2205 3114250 YBL034C STU1
SGTC_2419 paclitaxel 166.5 µM 0.101430356163135 0.454786766675779 no 1491 0.459604419998498 2065 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2770 toltrazuril 17.5 µM 0.10120500248159 0.454859838813177 no 1492 0.459693862852148 2240 68591 Kills coccidiodes.
SGTC_2800 7887935 81.82 µM 0.100738996539579 0.455010948576526 no 1493 0.459878827029545 2144 2961002
SGTC_1471 k673-0312 37 µM 0.0999577464420059 0.455264295815079 no 1494 0.460188935415887 2233 24099884
SGTC_1206 3978-0017 132 µM 0.0993465203914248 0.455462519594736 no 1495 0.460431571575684 2138 3873677
SGTC_3301 9125354 19.7965 µM 0.0984877425707429 0.455741044420705 no 1496 0.4607725023254 2196 41905162
SGTC_622 1348-1566 26.3 µM 0.0973862491999188 0.456098320275769 no 1497 0.461209832184666 2185 7340407
SGTC_3326 9140064 16.379 µM 0.0966603008767212 0.456333805311321 no 1498 0.461498083729709 2213 1868434
SGTC_1267 0828-0272 9.49 µM 0.0960255173320682 0.456539730647426 no 1499 0.461750153152872 2222 745334
SGTC_602 3130-1533 38.1 µM 0.0946643205191535 0.456981345507265 no 1500 0.462290729383707 2222 720941
SGTC_1034 k072-0165 12.7 µM 0.0946402026658822 0.456989170574538 no 1501 0.462300308011139 2225 5835461
SGTC_1240 0356-0016 42.1 µM 0.0945309442127525 0.457024619823417 no 1502 0.462343701285312 2169 4305613
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.0944336622614201 0.457056183546412 no 1503 0.462382338328738 2122 803109
SGTC_1932 st074806 40.9 µM 0.0936035398451233 0.457325532830978 no 1504 0.462712048786663 2176 17251235
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.0921823047442061 0.45778672551176 no 1505 0.46327659847286 2163 2724 A muscle relaxant with antifungal properties.
SGTC_1159 4092-0538 61.2 µM 0.0917310845516315 0.457933158982614 no 1506 0.463455849801876 2247 717301
SGTC_2980 9014342 25.29 µM 0.0916270825013741 0.457966911343754 no 1507 0.463497166616552 2138 2996599
SGTC_1042 0350-0096 82 µM 0.090710138387461 0.458264505383322 no 1508 0.463861457289205 2067 3122515
SGTC_375 3970-0961 9.27 µM 0.0884964481922476 0.458983054220833 no 1509 0.464741053598471 2182 2898222
SGTC_2927 9011802 47.9 µM 0.0880095321071637 0.459141121946961 no 1510 0.464934550008641 2128 43912568
SGTC_1602 st001878 87.6 µM 0.0876810237879506 0.459247769359658 no 1511 0.465065101174878 2206 595405 YLR310C CDC25
SGTC_577 r071-0003 38.6 µM 0.0868659612268531 0.459512385089227 no 1512 0.465389028109668 2246 4568517 YMR134W ERG29
SGTC_1093 fluphenazine 7.97 µM 0.0816092187176246 0.461219448926392 no 1513 0.467478735137079 2253 6602611 An atypical antipsychotic.
SGTC_1886 st057356 49.9 µM 0.0791051696332448 0.462032862002234 no 1514 0.468474485814436 2125 24207747
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.0788254112068965 0.462123748406158 no 1515 0.468585745855391 2229 15053
SGTC_2748 diazoxide 86.69 µM 0.0786264002190344 0.462188403223293 no 1516 0.468664894100916 2239 3019 A potassium channel activatior.
SGTC_1017 4239-0030 168 µM 0.0777143176896064 0.462484733936071 no 1517 0.469027652341545 2092 1149593
SGTC_2575 plumbagin 510 nM 0.0776827208665867 0.462494999948201 no 1518 0.469040219658041 2221 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2124 5246320 200 µM 0.0776805738584019 0.462495697525951 no 1519 0.469041073609931 2205 579342
SGTC_988 1497-1057 103 µM 0.0767666610576014 0.462792644538246 no 1520 0.469404586534275 2278 3533044
SGTC_2892 9047358 58.44 µM 0.0765737669537943 0.462855322022183 no 1521 0.469481314300819 2196 6466771
SGTC_2900 5328528 85.29 µM 0.0760507250497233 0.463025279756318 no 1522 0.469689371129954 2247 795359
SGTC_3009 9080819 71.4286 µM 0.073552907426386 0.463837015538856 no 1523 0.470683072005545 2196 17027216
SGTC_665 3914-0008 307 µM 0.0733178197808886 0.463913421657141 no 1524 0.470776605863917 2229 1069549
SGTC_758 0868-0029 16 µM 0.0728643621020884 0.464060804239646 no 1525 0.47095702672672 2289 762687
SGTC_2127 5253358 187.912 µM 0.0710302687759426 0.464656970420038 no 1526 0.471686832662532 2244 20612
SGTC_1201 1889-3372 45.9 µM 0.0709423344480151 0.464685555196643 no 1527 0.47172182510824 2160 5392199
SGTC_3319 9138450 16.7555 µM 0.0707649547557126 0.464743216496331 no 1528 0.471792411963093 2153 2029690
SGTC_367 0335-0881 7.1 µM 0.0703377980531624 0.46488207652505 no 1529 0.471962399248355 2228 23828853
SGTC_179 1273-0063 6.77 µM 0.069954958196463 0.465006533675805 no 1530 0.472114754957188 2256 3108139
SGTC_235 0330-0087 5 mM 0.0698156414075837 0.465051824926913 no 1531 0.472170198756635 2263 46494818 YHR062C RPP1
SGTC_1752 st044819 83.042 µM 0.0667492737413746 0.46604880065002 no 1532 0.473390653488487 2229 441209 YML126C ERG13
SGTC_850 0388-0143 75.9 µM 0.0666626334530024 0.466076973346878 no 1533 0.473425141147678 2179 67273
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.0666249491251121 0.466089227158156 no 1534 0.473440141670743 2297 16623 A steroid.
SGTC_1623 st003709 20.3 µM 0.0660923068755962 0.466262429848573 no 1535 0.473652167842433 2269 16192618
SGTC_115 0527-0192 112.043 µM 0.0655821451651956 0.466428328389648 no 1536 0.473855252300176 2145 4233931
SGTC_798 1287-0182 476 µM 0.0649986670220495 0.466618075714829 no 1537 0.47408753078721 2288 1649755
SGTC_426 0988-0037 14.6 µM 0.0618425654064819 0.467644571645266 no 1538 0.475344103023196 2319 5383008
SGTC_2283 7944793 200 µM 0.0615104019707687 0.4677526176878 no 1539 0.47547636525969 2256 2970533
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.0610419788309345 0.467904990289779 no 1540 0.475662888548507 2300 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_381 3461-2219 42.7 µM 0.0605896559432153 0.468052130129916 no 1541 0.475843005875403 2299 2883159
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.060247913318894 0.468163301300436 no 1542 0.47597909284184 2158 61125 An anti-inflammatory.
SGTC_1365 1672-3266 55.4 µM 0.0589868644442053 0.468573550385167 no 1543 0.47648128527445 2299 6415873
SGTC_1979 st071809 45.3 µM 0.0589345341683144 0.468590575388292 no 1544 0.476502125777956 2275 4976333
SGTC_2363 9053361 176 µM 0.0578805015966202 0.46893350393819 no 1545 0.476921907275999 2300 6469797 YMR079W SEC14
SGTC_2791 5663188 71.43 µM 0.0569101391461695 0.469249230873145 no 1546 0.477308388767044 2289 54690634
SGTC_1404 3909-7820 48.3 µM 0.0566776160195075 0.469324889827455 no 1547 0.47740100258772 2294 23741373
SGTC_1080 nisoldipine 24.4 µM 0.0564653639225596 0.469393953910705 no 1548 0.477485543535233 2309 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_19 0279-0214 38.434 µM 0.0554749311761627 0.469716240039215 no 1549 0.477880050605624 2303 3566274 YBR002C RER2
SGTC_2242 6630449 61.2675 µM 0.0537495189850175 0.470277735235071 no 1550 0.47856736467462 2239 691249 YDR170C SEC7
SGTC_983 1491-0821 12.2 µM 0.0530872699450926 0.470493264511488 no 1551 0.478831187131364 2306 46495113
SGTC_766 1391-0721 126 µM 0.0529891579071917 0.470525195859263 no 1552 0.478870273157288 2310 1020919 YIL115C NUP159
SGTC_1321 1326-2144 215 µM 0.0526509571324442 0.470635267458838 no 1553 0.479005007661966 2314 3513030
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.0522217862706036 0.470774949620386 no 1554 0.479175986841434 2293 23847180
SGTC_3158 9100007 49.47 µM 0.0514602943640619 0.471022801090513 no 1555 0.479479370207385 2273 19297233
SGTC_3071 9117417 49.47 µM 0.051344121094647 0.471060614320885 no 1556 0.479525655448842 2305 45595590 YGL055W OLE1
SGTC_3333 9141820 12.094 µM 0.0512458483710439 0.471092601307408 no 1557 0.479564809049387 2213 1939433
SGTC_145 3737-0113 38.366 µM 0.0509679444662608 0.471183057817192 no 1558 0.479675531972652 2315 6849351
SGTC_102 gallobenzophenone 83.616 µM 0.0506037118641467 0.471301616192175 no 1559 0.479820652488568 2319 70837
SGTC_2474 5321570 43.32 µM 0.0498908251809511 0.471533669456037 no 1560 0.480104694322492 2289 2841384
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.0494218734873313 0.471686324196174 no 1561 0.480291548468678 2250 5282362
SGTC_1629 st005085 44.9 µM 0.049328568138615 0.47171669776549 no 1562 0.480328726571144 2271 24207091
SGTC_1021 4476-0760 85.3 µM 0.0488287836435081 0.471879394760907 no 1563 0.480527871748645 2288 746768
SGTC_1325 1431-0015 227 µM 0.0482256938662296 0.472075727414319 no 1564 0.480768186631486 2296 1103340
SGTC_3238 9133470 49.47 µM 0.0456229484234479 0.472923114510942 no 1565 0.481805389008712 2325 3534688
SGTC_2416 tofa 880 nM 0.0453279518653368 0.473019165620785 no 1566 0.481922953981863 2132 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2514 salinomycin 42.74 µM 0.0413346284831694 0.474319546903487 no 1567 0.483514563556555 2334 23682228 A polyether potassium ionophore.
SGTC_2643 anethole 100 µM 0.0407035813781663 0.47452506575959 no 1568 0.483766103218292 2316 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2659 sanguinarine 24.21 µM 0.0402900176283069 0.474659758512089 no 1569 0.483930956048581 2337 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1588 farnesol 29.9 µM 0.0392736291904435 0.474990796308908 no 1570 0.484336115624001 2340 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1702 st027038 51 µM 0.0389592000910759 0.475093209399699 no 1571 0.484461458755341 2262 5521182
SGTC_1264 0783-0040 158 µM 0.0384075135039352 0.475272903892975 no 1572 0.48468138524689 2315 2855798
SGTC_1772 st048439 82.2 µM 0.0382982514748805 0.475308493148258 no 1573 0.484724942443028 2233 2927068 YDL195W SEC31
SGTC_2506 ethyl hematommate 54.16 µM 0.0382750801424388 0.475316040630582 no 1574 0.484734179694451 2172 3940691 An allergen.
SGTC_2286 7945697 125 µM 0.0379645863579528 0.475417177072882 no 1575 0.484857958826638 2288 1245733
SGTC_1368 1852-0141 284 µM 0.0378056162791725 0.475468958652699 no 1576 0.484921333215967 2297 2838987
SGTC_1480 1070-0044 41.2 µM 0.037201275797223 0.475665815225407 no 1577 0.485162260689454 2317 3124987
SGTC_543 3844-1095 191 µM 0.0370980121131173 0.475699452711966 no 1578 0.485203428521471 2311 4230703
SGTC_2584 androsterone 48.74 µM 0.0369330446505128 0.475753190170108 no 1579 0.485269195946087 2342 2754130 A steroid.
SGTC_2170 morpholine 200 µM 0.034223816871287 0.476635772119752 no 1580 0.486349337273137 2301 121171 Reacts with secondary amines.
SGTC_2061 5245884 80.95 µM 0.033540696709181 0.47685832963757 no 1581 0.486621706397349 2346 573863
SGTC_1684 st024538 14.6195 µM 0.0327792880268179 0.477106401711645 no 1582 0.486925297548035 2332 6732859
SGTC_2215 7188065 200 µM 0.0316275058379775 0.477481676931718 no 1583 0.48738455393592 2347 940217
SGTC_3268 9137683 49.47 µM 0.0304723360039336 0.477858075976033 no 1584 0.487845177901412 2343 1953228
SGTC_2005 4024620 188 µM 0.0302851735176896 0.477919062626601 no 1585 0.487919810484385 2354 236743
SGTC_1389 3405-0187 19 µM 0.0296565855273012 0.478123890974854 no 1586 0.488170468204192 2327 799890
SGTC_1025 k007-0731 70 µM 0.0273671075726513 0.478869976566806 no 1587 0.489083466385895 2342 6256118
SGTC_3084 9116877 49.47 µM 0.0270024372064571 0.478988820739195 no 1588 0.489228895065886 2359 27241325
SGTC_1443 4112-3303 14 µM 0.0268644870274391 0.479033778471378 no 1589 0.489283909267258 2351 704433
SGTC_3090 9117696 49.47 µM 0.0244327387478269 0.479826324437655 no 1590 0.490253717185226 2352 7923821
SGTC_1944 st076371 56.9 µM 0.0243365837549423 0.479857664559844 no 1591 0.4902920660743 2350 24208455
SGTC_1898 st060199 18.6 µM 0.0241879303165162 0.479906115923011 no 1592 0.490351352763627 2364 688866
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.0226664088614943 0.480402050010981 no 1593 0.490958185396536 2357 2333 A French combination drug.
SGTC_3145 9085516 49.47 µM 0.0222356185757687 0.480542469997672 no 1594 0.491130002546666 2303 25236195
SGTC_1904 st060225 78 µM 0.0211394794294155 0.480899777305785 no 1595 0.491567195946467 2366 66595
SGTC_8 0354-0001 70 µM 0.0210863134164233 0.480917108166837 no 1596 0.49158840139019 2362 4993152
SGTC_1162 k048-0130 20.1 µM 0.0201195876090208 0.481232244141971 no 1597 0.49197398732756 2362 6797406
SGTC_917 harmaline 728.087 nM 0.0190884553720582 0.481568388426553 no 1598 0.492385270516062 2350 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_264 promethazine 12.5 mM 0.0186409909131364 0.481714263837851 no 1599 0.492563751244726 2373 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_3181 9108277 49.47 µM 0.0180984658847745 0.481891132701122 no 1600 0.492780150899283 2369 17097298
SGTC_1911 st060208 74.3 µM 0.0179921532657412 0.481925792151441 no 1601 0.492822556593023 2365 688783
SGTC_3019 9081971 49.47 µM 0.017123319803103 0.48220904951407 no 1602 0.493169117562993 2356 16451803
SGTC_2040 5100729 123 µM 0.0168114899539985 0.482310714578525 no 1603 0.49329350176764 2368 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_922 1866-0035 480 µM 0.016768941653232 0.482324586578299 no 1604 0.493310473691316 2346 3156169
SGTC_3206 9114350 49.47 µM 0.0167333529888804 0.482336189547966 no 1605 0.493324669522406 2384 17087243
SGTC_618 k072-0232 33.2 µM 0.0161096117625205 0.482539550275128 no 1606 0.493573472716569 2358 5872756 YGL099W LSG1
SGTC_1783 st039459 87.517 µM 0.0155424361470129 0.482724472645788 no 1607 0.493799714712573 2371 729761
SGTC_1969 st069479 40.1 µM 0.0155299227769394 0.482728552556569 no 1608 0.493804706222522 2383 3895485
SGTC_2058 5236698 133 µM 0.0144334966797797 0.483086042816836 no 1609 0.494242067842092 2368 766665
SGTC_899 1083-0020 478 µM 0.014199190702626 0.483162440167483 no 1610 0.494335532824041 2380 767123
SGTC_2888 9058547 12.99 µM 0.0136165462582191 0.483352418754444 no 1611 0.494567951844715 2378 16476514
SGTC_2203 7227154 166.4 µM 0.0118982712867734 0.483912705878027 no 1612 0.49525338851568 2383 896304
SGTC_2908 7930301 100 µM 0.0103676617927355 0.48441182670051 no 1613 0.495863975457892 2392 2223178
SGTC_2285 7945142 200 µM 0.00912522539510351 0.48481699433147 no 1614 0.496359612294126 2376 2970608
SGTC_3346 9158254 43.5805 µM 0.00862820293952033 0.484979081416578 no 1615 0.49655788775211 2381 17639500
SGTC_1217 1183-1422 255 µM 0.00712088923515578 0.485470655932155 no 1616 0.497159200218164 2387 2849664
SGTC_2476 5806916 10.51 µM 0.0069639031218273 0.485521854501754 no 1617 0.497221827063123 2380 2870194
SGTC_1782 st039423 80.636 µM 0.00696343873077585 0.485522005955999 no 1618 0.497222012323856 2384 2068169
SGTC_2387 9077560 195.08 µM 0.00681769906006965 0.48556953688825 no 1619 0.497280152660115 2394 5303272
SGTC_329 k048-0121 21.3 µM 0.00575020234699827 0.485917692049693 no 1620 0.497706013804635 2383 6832902
SGTC_3272 9137413 49.47 µM 0.00417748067254821 0.486430641604894 no 1621 0.498333431181473 2398 17614870
SGTC_615 k087-0205 167 µM 0.00139030028619557 0.487339746410865 no 1622 0.499445350612066 2398 9642773
SGTC_2017 5132927 60.65 µM 0 0.487793250622145 no 1623 0.5 2405 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2390 9097792 176.6 µM 0 0.487793250622145 no 1624 0.5 2405 4497149
SGTC_274 sirtinol 40.1 µM -0.000264148872838874 0.487879415555793 no 1625 0.49989461984753 2407 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_905 2-aminofluorene 215 µM -0.00163576089243671 0.488326842176525 no 1626 0.499347426110397 2407 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2103 5378138 10 µM -0.00181120028472766 0.488384072445071 no 1627 0.499277436023202 2415 244142
SGTC_2323 6148992 148.28 µM -0.00232280863716373 0.48855096610488 no 1628 0.499073334258649 2419 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2879 9041815 71.43 µM -0.00271124916564071 0.488677682072114 no 1629 0.498918369400278 2410 4942971
SGTC_541 4513-1321 94 µM -0.00438257918541326 0.489222911487395 no 1630 0.498251609462623 2417 747515
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.00578229638775993 0.4896795495863 no 1631 0.497693210347684 2394 368090
SGTC_909 3448-9333 149 µM -0.00839414357340931 0.490531663796632 no 1632 0.496651260547136 2420 3344074
SGTC_1467 k284-1082 293 µM -0.00900952021427139 0.490732436640262 no 1633 0.496405770085273 2425 3334705
SGTC_3012 9080433 71.4286 µM -0.0105962747657249 0.491250142046726 no 1634 0.495772777087513 2424 17688859
SGTC_2166 5933061 31.504 µM -0.0108289334654407 0.491326052127329 no 1635 0.495679965021206 2436 2877375
SGTC_3128 9127691 49.47 µM -0.0109031681424027 0.49135027290966 no 1636 0.495650351418207 2452 41316314
SGTC_1980 st071811 45.7 µM -0.011067920695503 0.491404027358911 no 1637 0.495584628624951 2463 4974850
SGTC_1852 st056254 31.4 µM -0.0120793896054872 0.491734046595594 no 1638 0.495181137953236 2451 442583
SGTC_1078 idebenone 36.1 µM -0.012330668693942 0.491816034117439 no 1639 0.495080899567104 2444 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1244 0416-0015 52.5 µM -0.0133008007548386 0.492132572717794 no 1640 0.494693904667532 2435 96201
SGTC_402 epigallocatechin gallate 10 µM -0.0136069605697089 0.49223246881452 no 1641 0.494571775626897 2436 65064 An antioxidant.
SGTC_1730 st033808 45.1 µM -0.014047722047129 0.492376284594618 no 1642 0.494395954048344 2460 1045166
SGTC_1245 0418-0076 17.2 µM -0.0143874939773056 0.492487149237428 no 1643 0.494260418359665 2452 6790114
SGTC_2657 nystatin 74.44 µM -0.0144949728711147 0.492522218792336 no 1644 0.494217544955535 2442 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_557 1315-0110 16.2 µM -0.014576261202617 0.492548742602095 no 1645 0.494185119028928 2439 6833801
SGTC_1879 gemcitabine 100 µM -0.0150828369576983 0.492714035439074 no 1646 0.493983046764796 2434 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2811 7967822 32.47 µM -0.0151780473804563 0.492745102208287 no 1647 0.493945067649171 2453 2232244
SGTC_688 0527-0193 473 µM -0.0155163985815148 0.492855505167843 no 1648 0.493810100945867 2435 4007154
SGTC_2829 7992743 58.44 µM -0.016914690969088 0.493311769397566 no 1649 0.493252336372749 2429 16462845
SGTC_386 1509-0011 3.07 µM -0.0185282525357653 0.493838287015988 no 1650 0.492608719583623 2445 3107280
SGTC_2328 6201408 200 µM -0.0191334075313261 0.49403575658846 no 1651 0.49236734047371 2466 2890418
SGTC_736 0958-0254 92.6 µM -0.019216289226311 0.494062802027252 no 1652 0.492334281539346 2466 6812352
SGTC_2432 5630864 12.22 µM -0.0201923330034297 0.494381300576464 no 1653 0.491944972008552 2471 5714970
SGTC_774 k060-0086 136 µM -0.0216688297105366 0.49486311158739 no 1654 0.49135606410993 2445 5911235
SGTC_2843 9000894 45.46 µM -0.0217464036868178 0.494888425772472 no 1655 0.491325123861641 2440 2242070
SGTC_1020 4335-0961 93.3 µM -0.0218604081107766 0.494925628093689 no 1656 0.491279653486127 2441 669075
SGTC_2413 inermin 26.06 µM -0.0231180765058151 0.495336037687506 no 1657 0.49077804328641 2450 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_762 1165-0429 115 µM -0.0233034364705684 0.495396525846555 no 1658 0.490704115276123 2423 5967793
SGTC_2691 st077356 60.2 µM -0.0239681542285465 0.49561344276827 no 1659 0.490439005325101 2477 2839272
SGTC_2450 5739737 12.93 µM -0.024489476856716 0.495783566559485 no 1660 0.490231088725518 2468 2262825
SGTC_1974 st069448 26.9 µM -0.0249754014192573 0.49594213955181 no 1661 0.490037292155461 2452 6323587 YNR016C ACC1
SGTC_902 1120-0002 2.07 µM -0.0251819774827762 0.496009552237121 no 1662 0.489954906141782 2466 3280475
SGTC_1540 guanosine 70.6 µM -0.025728041550928 0.496187751767421 no 1663 0.489737128666599 2438 6802 Guanosine is a purine nucleoside
SGTC_520 3584-0023 682 µM -0.0268963739877421 0.496569021427798 no 1664 0.489271192805618 2515 1340790
SGTC_1120 ficusin 1.78878 µM -0.0274869079722694 0.496761735507458 no 1665 0.489035690914015 2524 6199 A DNA cross-linker.
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.0287622888685436 0.497177944141832 no 1666 0.488527088775489 2469 65057 A dermal irritant. YDR527W RBA50
SGTC_2886 9058944 51.95 µM -0.0289952656509561 0.497253974282257 no 1667 0.488434183235778 2450 4949929
SGTC_2468 5987765 72.9 µM -0.0298897140600077 0.497545871387378 no 1668 0.488077504588425 2512 26772094
SGTC_966 1300-0360 30.2 µM -0.0307994632515105 0.497842763144788 no 1669 0.487714734240722 2473 70588
SGTC_2408 sulbentine 18.36 µM -0.0317529414648456 0.498153926912832 no 1670 0.487334537482252 2573 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2486 5283202 22.39 µM -0.0320043663939513 0.498235978618916 no 1671 0.487234284401918 2496 1377751
SGTC_1279 0874-0590 65.2 µM -0.0321135327428237 0.498271604724476 no 1672 0.487190755704407 2509 3523074
SGTC_2199 6590217 200 µM -0.0333832770191242 0.498685982841448 no 1673 0.486684472617766 2479 703109
SGTC_811 0416-0114 265 µM -0.0351327854640397 0.49925693311881 no 1674 0.48598692926107 2519 6612453
SGTC_262 fenpropimorph 62.5 µM -0.0359723811415064 0.499530934915034 no 1675 0.485652190676048 2470 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_691 1548-0686 185 µM -0.0364338844093294 0.49968154646986 no 1676 0.485468198127584 2494 46495133
SGTC_114 0364-0001 490.298 µM -0.0367270554898681 0.499777222853656 no 1677 0.485351318015189 2498 4003655
SGTC_2706 st078239 82.5 µM -0.0373377627453249 0.499976527204703 no 1678 0.485107848078324 2468 15434492
SGTC_2275 7947463 200 µM -0.0374816131479355 0.499976527204703 no 1679 0.485050500213494 2462 1225414
SGTC_2875 9039966 71.43 µM -0.038303889277899 0.499708177348657 no 1680 0.484722694934156 2560 6463691
SGTC_630 4356-0227 183 µM -0.0384403920045114 0.499663629686528 no 1681 0.484668278302014 2466 779312
SGTC_2539 epi(13)torulosol 80 µM -0.0388495756254593 0.499530092647274 no 1682 0.484505159505437 2514 6708597
SGTC_141 0443-0274 32.331 µM -0.0399434328158092 0.499173112747421 no 1683 0.484069112167711 2469 1627241
SGTC_2774 tamoxifen 10.92 µM -0.0401313509224083 0.499111785799755 no 1684 0.483994203752736 2466 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1981 st071826 47 µM -0.040423104220568 0.499016572349299 no 1685 0.483877905398131 2531 11838600
SGTC_330 1488-0319 80.1 µM -0.0418361765698448 0.498555418233778 no 1686 0.483314647757739 2529 6846614
SGTC_2254 7938975 95.19 µM -0.0419838848665268 0.498507213945801 no 1687 0.48325577240162 2518 2969277
SGTC_94 0334-0113 514.748 µM -0.0423571489818198 0.498385400095621 no 1688 0.483106993914266 2476 6795178
SGTC_866 0495-0101 262 µM -0.0436764452056852 0.497954852215465 no 1689 0.482581157648928 2506 635694
SGTC_2356 9061756 188.97 µM -0.0443555131445033 0.497733241577248 no 1690 0.482310511045325 2472 20104043
SGTC_2119 5528445 120.635 µM -0.0466971180397547 0.496969075590203 no 1691 0.48137731365652 2551 791935
SGTC_1840 st055363 71 µM -0.0474308442919252 0.496729631438976 no 1692 0.481084923243288 2540 676033
SGTC_290 2043-6722 48.1 µM -0.0479865417060371 0.496548285980226 no 1693 0.480863484206833 2529 773758 YLR208W SEC13
SGTC_2366 9070441 60.58 µM -0.0480138122555842 0.496539386568137 no 1694 0.480852617357525 2512 6837235
SGTC_2044 5102272 200 µM -0.0488655701045197 0.496261426645444 no 1695 0.480513213571984 2540 592666
SGTC_589 1227-0070 34.1 µM -0.0498838167123445 0.495929137708865 no 1696 0.48010748681987 2556 2841384
SGTC_1899 st063254 59.6 µM -0.0506129464156054 0.495691199297356 no 1697 0.479816973150335 2483 3093813
SGTC_1775 st081588 35.1725 µM -0.0522576869843076 0.495154473447933 no 1698 0.479161684058239 2503 1426443 YGL099W LSG1
SGTC_1010 4112-3296 15.2 µM -0.0534348519246085 0.494770336216857 no 1699 0.478692718523636 2507 704384
SGTC_427 1354-0053 47.3 µM -0.0550226549581888 0.494252205647235 no 1700 0.478060207541791 2735 6813657
SGTC_23 0213-0011 39.996 µM -0.0558419960076912 0.493984842692809 no 1701 0.477733839571973 2537 627608
SGTC_867 0518-0118 155 µM -0.0558543281213973 0.493980818564283 no 1702 0.477728927436903 2520 6848158
SGTC_1679 SEC14.276 6.7 µM -0.0561853306795116 0.493872808369967 no 1703 0.47759708356217 2543 1005053 YMR079W SEC14
SGTC_2663 amphotericin b 100 µM -0.0578060488696821 0.493343954779941 no 1704 0.476951559968493 2517 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1603 st002045 67.8 µM -0.0579372891199027 0.49330113051335 no 1705 0.476899290286137 2519 5887985
SGTC_2407 paclitaxel 400 µM -0.0581857329487125 0.493220062419214 no 1706 0.476800342462851 2780 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1123 mangostin 811.285 nM -0.0587461838362338 0.493037186359195 no 1707 0.476577136725387 2573 5281650 An antioxidant.
SGTC_1385 3091-4834 14.1 µM -0.0596530232492425 0.49274128626153 no 1708 0.476215993539086 2565 4072814
SGTC_1936 st074407 74.3 µM -0.0600043273741903 0.492626657410894 no 1709 0.476076094078265 2504 809813
SGTC_786 4544-0069 423 µM -0.0605119356975404 0.492461028328145 no 1710 0.475873954979522 2633 748821 YLR208W SEC13
SGTC_1607 st000305 50.6 µM -0.0621183691165685 0.491936868922931 no 1711 0.475234284403626 2511 5457690
SGTC_1032 k061-1018 98.7 µM -0.0632969036792135 0.491552336437942 no 1712 0.474765040663635 2713 4005393
SGTC_1250 0485-0349 40.2 µM -0.0644271101006888 0.491183579837931 no 1713 0.474315072062658 2549 6842794 YDL195W SEC31
SGTC_2107 5363541 170.161 µM -0.0669335125067647 0.490365834059452 no 1714 0.47331731686416 2522 244052
SGTC_480 am 92016 50 µM -0.0673611744108338 0.490226307853465 no 1715 0.473147088642686 2586 2129 K+ channel blocker.
SGTC_46 0329-0187a 2.197 µM -0.0683213152820732 0.48991306288706 no 1716 0.472764928315252 2552 46494817
SGTC_49 0717-0965 32.132 µM -0.0684895487863001 0.489858177515347 no 1717 0.472697969700749 2787 5889349 YGL099W LSG1
SGTC_2213 7173844 200 µM -0.0690917734510564 0.489661706196067 no 1718 0.472458284608249 2523 892728
SGTC_1081 sertraline 6 µM -0.0702612083802001 0.489280193953173 no 1719 0.471992878698976 2542 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3343 9148379 18.9835 µM -0.0730026144782013 0.488385886551158 no 1720 0.470902018505737 2575 1955036
SGTC_184 1494-0393 24.714 µM -0.0739826457477054 0.488066192574734 no 1721 0.470512097050324 2526 3090647
SGTC_1649 st011737 51.3 µM -0.0774699884225083 0.486928657331783 no 1722 0.469124832636502 2585 1761035
SGTC_2052 5265182 7.135 µM -0.0786731814511059 0.486536212370459 no 1723 0.468646288723073 2599 1239884
SGTC_99 0109-0120 622.8 µM -0.0787095978455356 0.486524334651857 no 1724 0.468631805595315 2552 759414
SGTC_1716 st033144 30.6155 µM -0.0795396208066342 0.486253614265485 no 1725 0.468301709288489 2569 674617
SGTC_2428 5615643 7.78 µM -0.0817952438383737 0.485517952353052 no 1726 0.467404769134691 2612 2253075
SGTC_1522 st012842 45.6 µM -0.0824469771958949 0.485305401341876 no 1727 0.467145640388368 2545 3491067 YOR116C RPO31
SGTC_687 k029-0044 34.9 µM -0.0830971011830997 0.485093379357053 no 1728 0.466887165398489 2562 5829338
SGTC_292 k038-0015 474 µM -0.0832019038848623 0.485059200920525 no 1729 0.466845499454752 2635 46368540
SGTC_2644 guaiazulene 100 µM -0.0833137388534433 0.485022729230169 no 1730 0.466801038124704 2611 3515 A coloring agent.
SGTC_3171 9103192 49.47 µM -0.0856140958041685 0.484272563608446 no 1731 0.465886596386347 2561 13018434
SGTC_2834 9001755 58.44 µM -0.0866220344248098 0.483943883784494 no 1732 0.465485975396146 2698 2989575
SGTC_1144 3486-0183 12.5 µM -0.0869401060898435 0.483840165696131 no 1733 0.465359560072636 2592 6744069
SGTC_854 0422-0053 192 µM -0.0874905416311148 0.483660680047502 no 1734 0.465140801643875 2570 3596728
SGTC_614 0462-0418 107 µM -0.0886883655778766 0.483270105917276 no 1735 0.46466478951084 2572 5188303
SGTC_1756 st041558 35.5 µM -0.0898240668577303 0.482899802928547 no 1736 0.464213511453683 2621 3955792
SGTC_1194 1488-0194 225 µM -0.089853097942944 0.482890337341278 no 1737 0.464201976370059 2551 1391452
SGTC_721 1187-1332 279 µM -0.0914533955025967 0.482368575281647 no 1738 0.463566167994841 2546 25730
SGTC_483 fpl-64176 144 µM -0.0914696204332757 0.482363285447791 no 1739 0.46355972220066 2571 3423
SGTC_358 0075-0058 9.45 µM -0.0915024645146075 0.482352577261566 no 1740 0.463546674026995 2531 1069125
SGTC_1520 flindersine 88 µM -0.0915240961156712 0.48234552469761 no 1741 0.463538080326929 2816 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1645 Cervolide 78 µM -0.0916614552474547 0.482300741545948 no 1742 0.463483511338518 2636 23173 A fragrance.
SGTC_1352 1496-0991 99 µM -0.0920216502299476 0.482183308358708 no 1743 0.463340419088271 2575 3000039
SGTC_308 4092-1169 104 µM -0.0925998193731563 0.481994813008057 no 1744 0.463110743626137 2588 2268590 YDL196W YDL196W
SGTC_1694 st024011 44.9 µM -0.0935494377786821 0.481685226107437 no 1745 0.462733538095947 2583 2787533
SGTC_1761 st044296 37 µM -0.0955549966437285 0.481031426572223 no 1746 0.461937004525119 2565 1826700
SGTC_2243 6634756 200 µM -0.0956648642490036 0.480995611884151 no 1747 0.461893373569513 2816 885676
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.0971524149600799 0.480510714696332 no 1748 0.461302678285311 2620 279621
SGTC_2993 9054257 71.4286 µM -0.0986091310949595 0.480035896602359 no 1749 0.460724309897343 2578 6470217 YGL055W OLE1
SGTC_2200 6600604 21.907 µM -0.0997121612041546 0.479676381633777 no 1750 0.460286422709082 2579 2904777
SGTC_2999 9069765 71.4286 µM -0.100137054085636 0.479537899010356 no 1751 0.460117759127519 2650 2097066
SGTC_2308 7584454 197.62 µM -0.100534312664785 0.479408425292435 no 1752 0.459960071625825 2633 893577
SGTC_3271 9137798 49.47 µM -0.101704818380208 0.479026949105041 no 1753 0.459495488733709 2586 6498326
SGTC_2311 7694451 200 µM -0.103576180211388 0.478417098949148 no 1754 0.458752845705183 2657 2163142
SGTC_1392 3455-1037 33.9 µM -0.103934906492857 0.478300200893119 no 1755 0.458610502866361 2705 981132
SGTC_2853 9015042 58.44 µM -0.104606801691393 0.478081255580227 no 1756 0.458343908675848 2585 6457456
SGTC_1909 st060837 51.5 µM -0.104969210715775 0.477963162885069 no 1757 0.458200120002736 2645 678937
SGTC_501 nsc-95397 161 µM -0.105636766983518 0.477745641589087 no 1758 0.457935276056164 2758 262093
SGTC_954 1189-0853 2.85 µM -0.105782095641633 0.477698287539 no 1759 0.457877621342363 2559 2828194
SGTC_1861 st057647 17.4 µM -0.105806081220838 0.477690472081699 no 1760 0.457868105880353 2786 688668
SGTC_251 melphalan 456.522 µM -0.108937041810819 0.476670355152994 no 1761 0.456626213173771 2652 460612 A DNA alkylator.
SGTC_1393 3470-5649 58.2 µM -0.109162923308548 0.476596765188403 no 1762 0.456536633715729 2692 4108395
SGTC_1493 4348-0038 111 µM -0.11037478713336 0.476201965594352 no 1763 0.456056073946609 2603 800424
SGTC_1142 3253-1408 9.78 µM -0.110594613969106 0.476130353154027 no 1764 0.45596890935783 2585 256655
SGTC_303 1348-1668 34.2 µM -0.110989248740139 0.476001795904244 no 1765 0.455812436159094 2636 5380509
SGTC_2794 7785382 27.27 µM -0.111108188265713 0.475963050344216 no 1766 0.455765277825836 2576 2205081
SGTC_986 1493-0483 84 µM -0.111678025469812 0.475777424197369 no 1767 0.455539351725871 2590 40079
SGTC_934 2950-0684 338 µM -0.112477250605169 0.475517083122858 no 1768 0.455222503327937 2811 1121253
SGTC_2270 7924575 90.91 µM -0.113026986704298 0.475338017129175 no 1769 0.455004580003633 2824 1262135
SGTC_260 nsc-65238 3.989 µM -0.114273590317436 0.474931978415723 no 1770 0.454510458605797 2658 3246252
SGTC_164 4100-3994 89.624 µM -0.114280815669647 0.474929625078551 no 1771 0.454507594867669 2594 4615967
SGTC_1452 4194-0072 190 µM -0.114629998930158 0.474815895203661 no 1772 0.454369200364171 2767 1343545
SGTC_782 0083-0095 30.5 µM -0.115281811524309 0.474603603683874 no 1773 0.454110877269187 2589 3591729 An indicator and reagent.
SGTC_3035 9091303 49.47 µM -0.115345300795495 0.474582925986903 no 1774 0.454085716555624 2609 25237002
SGTC_415 dibenzyl ketone 100 µM -0.116089706034233 0.474340487218229 no 1775 0.453790723523544 2704 7593
SGTC_1548 st061468 90.8 µM -0.116994708113737 0.474045757889359 no 1776 0.453432123498286 2670 390799
SGTC_210 3551-0445 56.827 µM -0.117430477890705 0.473903847102158 no 1777 0.453259466642461 2752 2865180 YOR207C RET1
SGTC_412 gemfibrozil 100 µM -0.117567643204394 0.47385917915948 no 1778 0.45320512203885 2609 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_533 1222-0222 6.71 µM -0.117867611166295 0.473761495611272 no 1779 0.453086278429872 2793 3982874
SGTC_1572 epiandrosterone 68.9 µM -0.118656621565607 0.473504564601492 no 1780 0.452773702324016 2638 441302 A steroid.
SGTC_2133 5320837 200 µM -0.11870364704455 0.473489251710763 no 1781 0.452755073528314 2710 2841355
SGTC_2023 5144124 124 µM -0.119673972678542 0.473173293680762 no 1782 0.452370709473748 2643 2830192
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.121642147983032 0.472532467270126 no 1783 0.451591216031957 2726 6708739 YPR165W RHO1
SGTC_3251 9135047 49.47 µM -0.122736861177614 0.472176065693689 no 1784 0.451157736766174 2732 17682963
SGTC_88 0180-0332 8.668 µM -0.123358270676343 0.471973765680004 no 1785 0.450911699901263 2599 3101745
SGTC_3053 9095903 49.47 µM -0.126129691007742 0.471071617876329 no 1786 0.449814632561086 2627 17174018
SGTC_859 0439-0102 54.6 µM -0.126185180047481 0.471053556683334 no 1787 0.449792671100262 2616 610143
SGTC_2816 7982706 58.44 µM -0.128845365318354 0.470187760366676 no 1788 0.448740004172265 2729 2981853
SGTC_982 1491-0518 27.5 µM -0.129461765107447 0.469987163973589 no 1789 0.448496138660801 2685 3091256
SGTC_1234 0326-0494 15.5 µM -0.130080320605821 0.469785873699711 no 1790 0.448251439850702 2745 1547813
SGTC_469 w7 172 µM -0.132617042846323 0.468960455095227 no 1791 0.447248126617658 2629 45115570 A P450 inhibitor.
SGTC_884 0851-0618 334 µM -0.13315347217187 0.468785924475952 no 1792 0.44703600346174 2792 9642473
SGTC_1400 3771-8998 51.5 µM -0.135531837614692 0.468012181193687 no 1793 0.446095696851784 2683 670767
SGTC_2185 6113692 200 µM -0.137416778979425 0.467399047102001 no 1794 0.445350684575667 2756 874150
SGTC_1965 Pectolinarigenin 58.4 µM -0.137453035284666 0.467387254397493 no 1795 0.445336356361762 2669 5320438 An anti-inflammatory.
SGTC_2808 7946468 45.46 µM -0.138465699548155 0.467057887417332 no 1796 0.444936188124149 2718 2970879
SGTC_3239 9133757 49.47 µM -0.139132480944725 0.466841030432969 no 1797 0.444672730876759 2637 17036923
SGTC_2161 5662504 8.5105 µM -0.139560527316218 0.46670182230633 no 1798 0.444503614978308 2679 2859334
SGTC_2564 betulinic acid 100 µM -0.141216839199361 0.466163199394512 no 1799 0.443849321813015 2836 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_155 k072-0202 43.6 µM -0.141541964111105 0.466057477924862 no 1800 0.443720905575046 2631 5857737
SGTC_3190 9110366 49.47 µM -0.141983904743977 0.46591377511294 no 1801 0.443546359516556 2702 17123768
SGTC_2805 7950783 58.44 µM -0.143151950950113 0.465533990964107 no 1802 0.443085088237967 2772 1178958 YDL195W SEC31
SGTC_1062 mesoridazine 14.2 µM -0.143282910424264 0.465491412122785 no 1803 0.443033376036047 2640 4078 A neuroleptic.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.146347912335733 0.464495002199456 no 1804 0.441823372206011 2775 6728940
SGTC_2940 9060638 45.86 µM -0.146956129573148 0.464297301453622 no 1805 0.441583323904205 2761 4027022
SGTC_2446 5162541 200 µM -0.147064346735476 0.464262126434846 no 1806 0.441540615512336 2655 1549321
SGTC_1501 4491-0275 38.4 µM -0.14725380359403 0.464200545853607 no 1807 0.441465847144333 2662 5104718
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.147771061137979 0.46403242213251 no 1808 0.441261724216805 2802 5393153
SGTC_876 0720-0963 56.8 µM -0.149496297868992 0.463471716701399 no 1809 0.440581015207585 2864 765861
SGTC_2037 5169046 200 µM -0.150397851688973 0.463178738677497 no 1810 0.440225368048779 2786 5718022
SGTC_1902 st060212 70.5 µM -0.151962470628911 0.462670331818928 no 1811 0.439608267958865 2668 688944
SGTC_3312 9133330 71.43 µM -0.153198537571964 0.46226872763001 no 1812 0.439120855454016 2825 17617324
SGTC_72 0744-0168 198.391 µM -0.153564887964491 0.46214970596835 no 1813 0.438976411912004 2707 677577
SGTC_1636 st007707 68.9 µM -0.154778648243984 0.461755398017797 no 1814 0.43849791228633 2795 403051
SGTC_3173 9105693 49.47 µM -0.155927313003317 0.461382271920046 no 1815 0.438045157980643 2812 17096658
SGTC_1381 2324-0066 62.1 µM -0.156173518398605 0.461302300292811 no 1816 0.437948124922507 2797 10885928
SGTC_598 3937-0236 20.2 µM -0.15767890791767 0.460813358770898 no 1817 0.437354910800268 2749 1379313
SGTC_1689 st020265 53.493 µM -0.159573056645289 0.460198234826926 no 1818 0.436608702326757 2806 5758320 YPR016C TIF6
SGTC_2982 9019404 25.97 µM -0.160886999980945 0.459771588183865 no 1819 0.436091200714667 2713 22333232
SGTC_1238 0333-0287 48.8 µM -0.160979309275413 0.459741616442316 no 1820 0.43605484844791 2701 7226
SGTC_131 0141-0277 33.849 µM -0.161437380452317 0.459592889509869 no 1821 0.435874463715319 2843 1547771
SGTC_2803 7707263 71.43 µM -0.161670678493818 0.459517144278758 no 1822 0.435782597953891 2718 2199229
SGTC_799 1310-0557 151 µM -0.162428741508956 0.459271032961545 no 1823 0.435484119453473 2835 5354492
SGTC_2165 5727197 32.143 µM -0.163394471038019 0.458957523642846 no 1824 0.435103927928959 3101 1361712
SGTC_250 brefeldin a 552.239 µM -0.163612483303414 0.45888675282037 no 1825 0.435018108442481 2682 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_3022 9087993 49.47 µM -0.166107800725646 0.458076819891185 no 1826 0.434036057675431 2708 17173644
SGTC_171 k064-0041 9.68 µM -0.166700671374902 0.457884410733449 no 1827 0.433802788624257 2727 53325
SGTC_2764 methyldopa 94.69 µM -0.168325939360722 0.457356999974831 no 1828 0.433163434170309 2833 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_3156 9099931 49.47 µM -0.169517193849968 0.456970477249963 no 1829 0.432694924667476 2710 18111053
SGTC_1070 indatraline 8.81 µM -0.170411596745271 0.456680299792845 no 1830 0.432343226325156 2728 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1881 5652484 16 µM -0.17391006637288 0.455545489857134 no 1831 0.430968070682188 2814 2255129
SGTC_1342 1486-1464 234 µM -0.174597430772435 0.455322569567648 no 1832 0.430697983761319 2724 3253938
SGTC_742 0kpi-0133 140 µM -0.17570219382403 0.454964311530595 no 1833 0.430263955848562 2885 2728852
SGTC_1169 aniline yellow 25.8 µM -0.176481373825935 0.454711657186786 no 1834 0.429957890275145 2764 6051 A DNA damaging agent.
SGTC_2789 5281112 71.43 µM -0.176688706807824 0.454644431158089 no 1835 0.429876455985271 2777 765948
SGTC_136 0097-0015 404.482 µM -0.178285098294183 0.454126857887876 no 1836 0.429249540584956 2684 4861337
SGTC_2205 7238770 200 µM -0.179718567689552 0.453662172665663 no 1837 0.428686757938017 2832 279867
SGTC_2949 9072542 2.23 µM -0.180827419575977 0.453302761601345 no 1838 0.428251520087886 2822 16457352
SGTC_2976 9009005 19.48 µM -0.182158476840824 0.452871377864326 no 1839 0.427729179213055 2941 2993148
SGTC_142 0335-0849 62.6745 µM -0.183277611611899 0.45250871932677 no 1840 0.427290100097536 2744 3889043 YPR107C YTH1
SGTC_1663 st014140 55.4 µM -0.18385474899327 0.452321711918767 no 1841 0.427063702323057 2737 4207120
SGTC_2681 menadione 3.18 µM -0.184349001902144 0.452161569624908 no 1842 0.426869837320418 2794 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1725 st036284 20.55 µM -0.184982949746871 0.451956176338611 no 1843 0.426621204453961 2980 707914
SGTC_435 c-PAF 6.7 µM -0.185040363365493 0.451937575487021 no 1844 0.426598688404967 2867 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2822 7994718 71.43 µM -0.187657564840221 0.451089767787674 no 1845 0.425572548773458 2686 1018011
SGTC_1778 st046819 58.9 µM -0.18781288481071 0.451039460917727 no 1846 0.425511667445661 2755 671715
SGTC_2351 9026858 72.31 µM -0.189074476143283 0.450630870995005 no 1847 0.425017222872616 2735 1409300
SGTC_1920 st075728 45.7 µM -0.189879588414459 0.450370147662468 no 1848 0.424701743782983 2920 3400306
SGTC_2066 5222451 176 µM -0.190002405213269 0.450330377194832 no 1849 0.424653622888499 2738 2281147
SGTC_487 nimodipine 119 µM -0.190823790913589 0.450064409374662 no 1850 0.424331824361166 2821 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2011 4012611 177 µM -0.191242109094136 0.449928964965386 no 1851 0.424167957052601 2745 2049887
SGTC_1675 st018485 24.5 µM -0.191746055602364 0.44976580328701 no 1852 0.42397056406693 2824 3323024
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.192891338043556 0.44939502927363 no 1853 0.423522034441993 2776 115019
SGTC_1477 0139-0234 16 µM -0.194343761303271 0.448924884999301 no 1854 0.42295336111101 2733 620880
SGTC_39 0986-0283 58.349 µM -0.195566701886444 0.448529079036167 no 1855 0.422474662503574 2888 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3254 9136651 49.47 µM -0.195607511636201 0.448515871800245 no 1856 0.42245869021389 2751 16454030
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.195683938424939 0.448491137995911 no 1857 0.422428778322271 2833 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_857 0438-0306 1.35 µM -0.196321826847178 0.448284707630875 no 1858 0.422179139224292 2841 4686136
SGTC_3208 9114115 49.47 µM -0.196388867141609 0.44826301318733 no 1859 0.422152904664869 2827 650895
SGTC_24 0417-1663 219 µM -0.197276157399034 0.447975897956981 no 1860 0.421805718171627 2828 4329390
SGTC_938 3126-1755 342 µM -0.19766616732216 0.447849704588501 no 1861 0.421653130975057 2884 1777771
SGTC_3150 9097574 49.47 µM -0.198369094224392 0.447622275729252 no 1862 0.421378148089163 2874 17217476
SGTC_14 0354-0009 295 µM -0.201560386692509 0.446589964943673 no 1863 0.420130208193998 2722 1713507
SGTC_1650 st011916 45.8 µM -0.201958604738225 0.446461175680964 no 1864 0.419974542966739 2838 242528
SGTC_2341 7987486 176.74 µM -0.205438862630625 0.445335853619924 no 1865 0.418614629875697 2900 1258686
SGTC_1398 3558-0053 112 µM -0.205792961394574 0.445221382278413 no 1866 0.418476319760077 2751 4532369
SGTC_3279 9140807 49.47 µM -0.207968746576972 0.444518105540233 no 1867 0.417626685210048 2752 45595718
SGTC_611 3453-1652 23.7 µM -0.208847988254384 0.444233958603536 no 1868 0.417283454028801 2869 1560575
SGTC_946 3434-1334 87.4 µM -0.208883722394381 0.444222410908925 no 1869 0.417269505758215 2919 4047976
SGTC_1186 1319-0216 26 µM -0.210203753180343 0.443795868566405 no 1870 0.416754325195534 2944 4565136
SGTC_1587 estradiol valerate 56.1 µM -0.211851492260899 0.443263525052207 no 1871 0.416111447560471 2929 13791 A steroid.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.213349691840569 0.442779582875348 no 1872 0.415527108581672 2789 756377
SGTC_1790 st045711 43.5 µM -0.216288232610532 0.441830636251759 no 1873 0.41438154050394 2942 585119
SGTC_1284 0929-0043 16 µM -0.216624405401999 0.441722096727172 no 1874 0.41425053228236 2850 1239883
SGTC_2654 protoveratrine a 100 µM -0.216648226008277 0.441714405975369 no 1875 0.414241249634497 2788 5702278 A heart drug and vasodilator.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.216967142234759 0.441611442386891 no 1876 0.414116975842417 2937 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_399 oxolinic acid 75 µM -0.217003694158505 0.441599641680024 no 1877 0.414102733007763 2778 4628 A DNA gyrase inhibitor.
SGTC_1262 0737-0114 49.6 µM -0.218138166082297 0.441233405780065 no 1878 0.413660730561252 2897 765919
SGTC_3074 9116018 49.47 µM -0.219188052229452 0.4408945210426 no 1879 0.413251781071531 2758 17027303
SGTC_2091 4-phenylthiadiazole 200 µM -0.219451124398024 0.440809612755907 no 1880 0.413149324468599 2811 270010
SGTC_2819 7996655 46.38 µM -0.220198406167943 0.440568437465445 no 1881 0.412858318930872 2876 6456960
SGTC_3335 9143315 29.6265 µM -0.222903596390711 0.439695558147127 no 1882 0.411805268645674 2845 4899691
SGTC_1122 capsaicin 818.572 nM -0.225039812501573 0.439006475655175 no 1883 0.410974151300523 2943 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1670 st016595 4.04 µM -0.225355012762899 0.438904816621849 no 1884 0.410851553055028 2812 597879
SGTC_361 000s-0510 1.45 µM -0.225370555075419 0.438899803987611 no 1885 0.410845508043329 2891 660
SGTC_2998 9066762 71.4286 µM -0.227408684699003 0.438242561110329 no 1886 0.410052983886036 2964 4945196
SGTC_1760 st045453 10.4495 µM -0.227453527687339 0.438228102341174 no 1887 0.410035550863524 2910 3323419 YIL048W NEO1
SGTC_2845 9003024 42.97 µM -0.227551825169587 0.438196408475093 no 1888 0.409997337658145 3046 2990173
SGTC_3106 9121286 49.47 µM -0.227648553232881 0.438165221020675 no 1889 0.409959735399701 3007 15943471
SGTC_2895 9054447 58.44 µM -0.229474442671473 0.437576582602338 no 1890 0.409250091235748 2823 2697450
SGTC_282 k297-0036 65.7 µM -0.229479491656639 0.437574955078786 no 1891 0.409248129324954 2948 5061378
SGTC_2253 7938677 135.83 µM -0.22978894992939 0.437475204252492 no 1892 0.40912788583296 3013 2301972
SGTC_2823 7987624 58.44 µM -0.229959887262199 0.437420105990259 no 1893 0.409061469875154 3011 2239440
SGTC_2228 7354201 200 µM -0.230640231058996 0.437200822685262 no 1894 0.408797155120927 2836 753451
SGTC_2141 5621638 7.665 µM -0.231372785535386 0.436964732795482 no 1895 0.408512602797349 2949 2856238
SGTC_2010 4012422 159 µM -0.231823546078156 0.436819471464157 no 1896 0.40833753402969 2895 952393
SGTC_512 prima-1 270 µM -0.232487718887022 0.436605451784531 no 1897 0.408079612419962 2969 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2648 atorvastatin 78.68 µM -0.232937958148587 0.436460379515947 no 1898 0.40790479135585 2921 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_763 3453-1109 128 µM -0.233476848984716 0.436286753927989 no 1899 0.407695572339407 2960 1560353
SGTC_641 4092-0595 30 µM -0.234682333736198 0.435898402508084 no 1900 0.407227650238769 2876 786260
SGTC_1943 st076331 65.2 µM -0.23477602191062 0.435868223095668 no 1901 0.407191289683251 2917 24208415
SGTC_2761 levamisole 97.89 µM -0.234919931493283 0.435821866780983 no 1902 0.407135439663225 2957 26879 An alkaline phosphatase inhibitor.
SGTC_284 0988-0104 32.6 µM -0.237394916414606 0.435024760395209 no 1903 0.406175216572204 2918 4666532
SGTC_319 1348-1596 45.5 µM -0.238326865962736 0.434724680168236 no 1904 0.405813792779364 3024 5380505
SGTC_2464 5717415 7.67 µM -0.23834706209614 0.434718177592016 no 1905 0.40580596130818 2829 5285744
SGTC_1118 chelidonine 707.474 nM -0.238365891503382 0.434712115078363 no 1906 0.405798659847477 2947 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1504 k297-0033 30 µM -0.239809706460803 0.434247295078271 no 1907 0.405238890923676 2794 4388117
SGTC_1609 st001574 46.4 µM -0.239916431086834 0.434212939884053 no 1908 0.405197521326263 2827 3960012
SGTC_2692 st077426 47.7 µM -0.240065867731066 0.434164836311216 no 1909 0.405139597077063 2990 25238571
SGTC_122 0236-0016 402.397 µM -0.240941486848434 0.433882994617045 no 1910 0.404800233637515 2868 6808838
SGTC_2617 dihydrotanshinone i 20.83 µM -0.244615709786339 0.43270071464375 no 1911 0.403376999450386 2839 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1621 st003705 32.4 µM -0.245163439257419 0.432524519289968 no 1912 0.403164941942323 3004 24207032
SGTC_489 paxilline 115 µM -0.246109695849619 0.432220156097925 no 1913 0.402798658838737 2900 105008 A toxic potassium channel blocker.
SGTC_3121 9125696 49.47 µM -0.247875744572325 0.431652214693476 no 1914 0.402115273686635 2852 1235365
SGTC_838 0109-0203 71.4 µM -0.248673919539742 0.431395576877721 no 1915 0.401806512204423 2839 759422
SGTC_1236 0330-0013 258 µM -0.251195402553493 0.430585033227292 no 1916 0.400831519434054 2895 4617066
SGTC_132 0417-1715 25.805 µM -0.2514153768653 0.430514335172114 no 1917 0.400746490207391 2956 6769098
SGTC_111 0083-0039 52.457 µM -0.251681204647778 0.430428903135542 no 1918 0.400643742981174 2818 759313
SGTC_2507 purpurin 79.67 µM -0.252122039237316 0.430287234390818 no 1919 0.400473367626742 2842 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_783 0848-0141 92.7 µM -0.253621495613369 0.429805429081841 no 1920 0.399893994200995 2832 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.254132013559098 0.429641413275011 no 1921 0.399696785898417 2922 6857784
SGTC_368 fentichlor 4.58 µM -0.254786074204446 0.429431298773685 no 1922 0.399444165786931 2925 7329 A pesticide.
SGTC_1348 1493-0373 93.8 µM -0.25480776869096 0.429424329844383 no 1923 0.399435787370875 2914 3010129
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.255928482782554 0.429064352336098 no 1924 0.399003030391904 2946 5379071
SGTC_3299 9121982 43.1275 µM -0.255936093325971 0.429061908002744 no 1925 0.399000092050199 2891 17594604 YPL160W CDC60
SGTC_3213 9129884 49.47 µM -0.25744331142434 0.428577877585109 no 1926 0.398418285800263 2976 17190742
SGTC_3217 9129673 49.47 µM -0.260574361860229 0.4275727112057 no 1927 0.397210381532585 3044 17248312
SGTC_3222 9128301 49.47 µM -0.261473597093438 0.427284114784477 no 1928 0.396863653974045 2890 4911358
SGTC_1628 st004252 77.7 µM -0.263036188423441 0.426782716546644 no 1929 0.396261343295941 3031 692968
SGTC_2064 5220758 200 µM -0.264987424944423 0.426156777508496 no 1930 0.395509574543883 3038 788518
SGTC_2210 7115885 190.385 µM -0.26514775092874 0.42610535462925 no 1931 0.395447821689625 2881 2927039
SGTC_2092 5303694 80.6725 µM -0.266283849613702 0.425740998928806 no 1932 0.395010305180763 2888 1963699
SGTC_2080 5212524 12.4 µM -0.266339999513567 0.425722992859918 no 1933 0.394988685039547 2929 260183
SGTC_526 4469-0568 170 µM -0.267839006783183 0.425242350749229 no 1934 0.394411622108651 2868 2901964
SGTC_669 0108-0021 26.2 µM -0.267888023371969 0.425226635928296 no 1935 0.394392756420643 3006 17201
SGTC_2675 theaflavin digallate 100 µM -0.267968892611593 0.425200709340553 no 1936 0.394361631706772 2895 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_636 0kpi-0074 126 µM -0.269287662580351 0.424777958893225 no 1937 0.393854162738343 2970 616434
SGTC_1432 4049-0298 68.4 µM -0.269612852918639 0.424673727787109 no 1938 0.393729055608478 2992 741646
SGTC_3076 9116187 49.47 µM -0.270024684879953 0.424541733574593 no 1939 0.393570631481988 2996 27241210
SGTC_2180 6301957 200 µM -0.270629188534003 0.424348002446119 no 1940 0.393338122038556 3007 845462
SGTC_1422 4031-0024 15.5 µM -0.270730864476942 0.424315419168297 no 1941 0.393299018289202 2941 782427
SGTC_1141 3253-0389 52.6 µM -0.271154120193552 0.42417978734823 no 1942 0.393136249117897 2985 5402031
SGTC_707 0865-0008 204 µM -0.271487786658824 0.42407287063204 no 1943 0.393007945968342 2906 723043
SGTC_3327 9140648 26.9345 µM -0.271925572904474 0.423932599300584 no 1944 0.392839623773847 3020 8029710
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.272076333025237 0.423884296397335 no 1945 0.392781663422684 2991 7104
SGTC_2717 st081029 62.2815 µM -0.273565627631943 0.423407194280027 no 1946 0.3922092258958 3001 5292846
SGTC_159 3970-0959 50 µM -0.274523888747226 0.423100270411167 no 1947 0.391841023980558 2979 6615653
SGTC_2192 5915882 198.485 µM -0.275649910487199 0.422739673716095 no 1948 0.391408485570174 2869 2876149
SGTC_3021 9087658 49.47 µM -0.276908267707679 0.422336774565646 no 1949 0.390925272017339 2959 25237042
SGTC_546 peri-Naphthalide 147 µM -0.280043350621035 0.421333342116612 no 1950 0.389722122974136 2964 223824 A penicillin ester.
SGTC_1792 st045773 43.6 µM -0.280922303719024 0.421052110773862 no 1951 0.389384996664269 2890 2919270
SGTC_3064 1327-0027 10 µM -0.280968641076046 0.421037285709979 no 1952 0.389367226075571 2880 16000455 YPR107C YTH1
SGTC_953 1188-0045 9.7 µM -0.281203986596378 0.420961991552374 no 1953 0.389276973562693 3017 6144426
SGTC_428 3448-4153 16.5 µM -0.281945039253115 0.420724925265562 no 1954 0.388992826756715 2843 3834874
SGTC_1956 st077085 54 µM -0.284011150614396 0.42006411843017 no 1955 0.388200917704491 2941 24208685
SGTC_1833 st055984 71 µM -0.284307094236317 0.419969484834071 no 1956 0.388087524980181 2932 676288
SGTC_1303 1160-0052 261 µM -0.285035675937718 0.419736526720788 no 1957 0.387808404834936 2933 3562476
SGTC_1426 4048-4480 71.7 µM -0.285157535213217 0.419697565945018 no 1958 0.387761726117638 3023 14224343
SGTC_2560 caryophyllene 100 µM -0.285977699430824 0.419435364019444 no 1959 0.387447600929559 2874 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_331 k048-0133 24.5 µM -0.288272863361209 0.418701803374939 no 1960 0.386568938881027 2905 6813582
SGTC_639 0833-0042 114 µM -0.288423812661338 0.418653568128781 no 1961 0.386511170989951 2947 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_495 decylubiquinone 155 µM -0.288914402750854 0.418496810474783 no 1962 0.386323440858301 2980 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2685 mycophenolic acid 18.85 µM -0.289236047050032 0.418394042886426 no 1963 0.386200374280233 2948 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1097 itavastatin 7.23 µM -0.289407737167491 0.418339188980774 no 1964 0.386134687407701 2954 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1428 4049-0204 61.7 µM -0.289616107513585 0.41827261810771 no 1965 0.386054971441451 3014 X1428
SGTC_2913 7966556 36.57 µM -0.290397256287507 0.418023074871262 no 1966 0.385756171239536 3036 2976516
SGTC_2296 7971656 126.45 µM -0.290855143062216 0.417876815191781 no 1967 0.385581054715919 2994 666570
SGTC_1717 st033143 58.0435 µM -0.29154643092336 0.417656023303905 no 1968 0.385316719297049 3090 674616
SGTC_729 4092-0585 94.1 µM -0.291605598335499 0.417637126904247 no 1969 0.385294097269538 2901 2169061
SGTC_2035 5154463 94.595 µM -0.29250129516964 0.417351089899563 no 1970 0.384951684879557 3071 2769623
SGTC_2769 toremifene 3.73 µM -0.293629744366515 0.416990786681743 no 1971 0.384520422231897 3122 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3323 9138564 53.9225 µM -0.294880522160822 0.416591506555304 no 1972 0.384042575881677 3094 43912313 YNL103W MET4
SGTC_2370 9071495 200 µM -0.295541586602921 0.416380512677178 no 1973 0.383790094377869 3001 21791103
SGTC_236 1509-0011 5.31 µM -0.295702424753847 0.416329181134185 no 1974 0.383728672636509 3036 3107280
SGTC_1082 camptothecin 424.86 nM -0.295983004902538 0.41623963731409 no 1975 0.383621530168336 2782 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1304 1165-0502 251 µM -0.298556337780875 0.415418592050274 no 1976 0.382639292047979 2953 767425
SGTC_796 1234-0020 70.7 µM -0.298615543480902 0.415399706264032 no 1977 0.38261670215696 2912 46495034
SGTC_675 1309-0189 238 µM -0.299097763139566 0.415245892252381 no 1978 0.38243272648303 2970 4246530
SGTC_3315 9136395 68.55 µM -0.300901564997046 0.414670647396294 no 1979 0.381744778448623 3131 16876844
SGTC_3130 9127414 49.47 µM -0.301054834257831 0.414621777187098 no 1980 0.381686340599775 2955 1494646
SGTC_3337 9144342 33.5465 µM -0.302862112593423 0.414045622747826 no 1981 0.380997472928214 3027 17682949
SGTC_1185 1319-0113 81.3 µM -0.303073134879998 0.413978361565688 no 1982 0.380917063573139 3040 4672763
SGTC_2292 7671323 168.05 µM -0.30365139468235 0.413794060141457 no 1983 0.380696745921729 3102 937504
SGTC_3045 9092950 49.47 µM -0.305117076979657 0.413327006925063 no 1984 0.380138492707132 3087 44120432
SGTC_2897 9048598 12.99 µM -0.306458732007317 0.412899583622751 no 1985 0.379627698132058 2955 6467404
SGTC_2517 totarol 10 µM -0.308137674124737 0.41236485317394 no 1986 0.3789887875888 3035 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2885 9057732 51.95 µM -0.308919312619281 0.41211596260719 no 1987 0.378691452758477 3108 6471414
SGTC_1366 1683-0113 21.9 µM -0.309000761287613 0.41209002962498 no 1988 0.37866047385934 2948 708623
SGTC_3232 9132874 49.47 µM -0.310010677695632 0.411768507559934 no 1989 0.378276418243413 2958 3784940
SGTC_2004 4023728 41.89 µM -0.31177539863542 0.411206824425447 no 1990 0.377605610912779 3114 360084 YDR527W RBA50
SGTC_1744 st037937 38.9 µM -0.312672856849054 0.410921247210257 no 1991 0.377264609696462 3147 1016152
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.313643543531411 0.410612421351118 no 1992 0.376895892058181 3079 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2318 6029776 164 µM -0.314625007286866 0.410300223080753 no 1993 0.37652319483927 3156 818325
SGTC_1550 gossypolone 36.6 µM -0.315486963596093 0.410026086348278 no 1994 0.376195973805776 2961 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2176 5809774 33.9695 µM -0.315778984187533 0.409933222033857 no 1995 0.376085135360306 3081 2870539
SGTC_280 3448-3607 3.04 µM -0.316810543765724 0.409605220321946 no 1996 0.375693681628082 3060 626179
SGTC_1431 4049-0260 9.09 µM -0.320529927778222 0.408423106448456 no 1997 0.37428332351102 2951 3854841
SGTC_1656 st012921 11 µM -0.320949620415607 0.408289769653159 no 1998 0.374124284887732 3080 6732821
SGTC_2945 9067681 61.76 µM -0.322118106449304 0.407918596380973 no 1999 0.373681610888973 2953 16456930
SGTC_1356 1502-0781 85.8 µM -0.322756891642507 0.407715719160296 no 2000 0.373439681302662 2978 567702
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.323388819189716 0.407515044265212 no 2001 0.373200398012611 3014 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2395 5646831 180.19 µM -0.325182252670874 0.406945653909618 no 2002 0.372521569864537 3150 6808628
SGTC_182 3448-4371 550.524 µM -0.326462669734007 0.406539259408233 no 2003 0.372037164347015 2991 3491403
SGTC_1317 1273-0028 910 nM -0.328215535986119 0.40598307645375 no 2004 0.371374350952853 2993 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2745 rifampicin 24.3 µM -0.328667818998281 0.405839598186342 no 2005 0.371203390440414 3031 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1087 pterostilbene 9.05 µM -0.329563910860068 0.405555367290006 no 2006 0.370864747681668 3116 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.329758811676698 0.405493553392122 no 2007 0.370791105796537 2928 6708630 An antioxidant.
SGTC_3028 9087778 49.47 µM -0.33007375513505 0.405393672272579 no 2008 0.370672116658552 2982 17217395
SGTC_3000 9075062 71.4286 µM -0.330787046041212 0.405167482091239 no 2009 0.370402673174057 3003 17057871
SGTC_328 k915-0120 63.5 µM -0.331872846581073 0.404823226989313 no 2010 0.36999263737319 3101 6624543
SGTC_3086 9117350 49.47 µM -0.332734542941425 0.404550076942094 no 2011 0.369667336172357 3025 2679265
SGTC_3195 9113082 49.47 µM -0.335376994223707 0.403712734056339 no 2012 0.368670360008895 3094 17018038
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.337125450622004 0.40315892351094 no 2013 0.368011166236663 3051 1241132 A phosphatase inhibitor.
SGTC_1747 st037496 66.6 µM -0.339223066735924 0.402494775531551 no 2014 0.367220846822977 3011 723305
SGTC_960 1222-0186 7.7 µM -0.342314142498605 0.401516591231659 no 2015 0.366057246799809 3125 3126296
SGTC_4 0960-0234 25.671 µM -0.342622170206252 0.401419148225985 no 2016 0.36594136056412 3092 6821112
SGTC_2025 5147754 141 µM -0.343250724929785 0.401220327145615 no 2017 0.365704923551029 3080 315777 YLR208W SEC13
SGTC_1478 0453-0656 35.7 µM -0.344374753098602 0.400864844339597 no 2018 0.365282236568123 3087 5258496
SGTC_2463 5473429 200 µM -0.345247832269438 0.400588782756987 no 2019 0.364954030960337 3062 5399405
SGTC_1972 st070201 17.4 µM -0.345784235420144 0.400419200410978 no 2020 0.364752436750124 3141 2829099
SGTC_1022 4477-0945 21.3 µM -0.347900526170056 0.399750324455771 no 2021 0.363957445051152 3008 4648966
SGTC_350 k064-0020 19.8 µM -0.348246204798693 0.399641096976963 no 2022 0.363827645226546 3203 2790705
SGTC_166 k072-0058 166.424 µM -0.348558170959779 0.399542528700181 no 2023 0.363710517602415 3144 5846229
SGTC_189 3970-0742 2.116 µM -0.350334557437442 0.398981386970915 no 2024 0.363043816727574 3064 2891807
SGTC_479 n-linoleoylglycine 10 µM -0.351666548310908 0.398560761973167 no 2025 0.362544175294531 3034 6433346 An anti-infammatory.
SGTC_1865 st057639 52.2 µM -0.353824043124921 0.397879703963403 no 2026 0.361735376890535 3011 688818
SGTC_1466 k213-0079 57.5 µM -0.357294929919441 0.396784700090407 no 2027 0.360435512588778 3036 3657981
SGTC_460 trequinsin 123 µM -0.358700534345568 0.396341487461177 no 2028 0.359909564302571 3107 5537 A vasodilator.
SGTC_69 0096-0274 206.684 µM -0.359069080831307 0.396225300192527 no 2029 0.359771705614431 3312 6741392
SGTC_646 4092-0839 27.3 µM -0.361171692569918 0.395562611371674 no 2030 0.35898555099018 3190 877796
SGTC_2456 5770359 74.46 µM -0.362104462340437 0.395268723010266 no 2031 0.358636984572516 3200 3118787
SGTC_2026 5148700 152 µM -0.362465519937384 0.395154980344729 no 2032 0.358502092668243 3019 79838
SGTC_1387 3342-1166 1.8 µM -0.362976817935507 0.394993923274323 no 2033 0.358311100825125 3094 3418228
SGTC_972 1319-0219 195 µM -0.366776753355306 0.393797520849019 no 2034 0.356892774570195 3115 23903702
SGTC_1821 st053465 65.6 µM -0.367177598750398 0.393671373655372 no 2035 0.356743273860238 3117 675086
SGTC_2430 5571206 200 µM -0.367964708022929 0.393423700592185 no 2036 0.356449774853879 3208 1731771
SGTC_51 1013-0126 23.419 µM -0.368338908046719 0.393305969330417 no 2037 0.35631027213904 3325 1627850
SGTC_1838 st055369 84.5 µM -0.369504216248197 0.392939401202966 no 2038 0.355875965537411 3065 676036
SGTC_519 k048-0011 62.8 µM -0.37160049149137 0.392280220229118 no 2039 0.355095161551114 3143 6836379
SGTC_1074 carmofur 3.8 µM -0.371682601296545 0.392254406794008 no 2040 0.355064590296186 3059 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3338 9144300 39.5675 µM -0.371844451327442 0.392203526253536 no 2041 0.355004332764164 3113 4901274
SGTC_417 st075190 100 µM -0.375148095338396 0.3911653687651 no 2042 0.353775164850666 3202 222757
SGTC_1925 st057770 10.1 µM -0.375157578480905 0.391162389835817 no 2043 0.353771638697962 3067 5989122
SGTC_1156 4092-0367 4.88 µM -0.376298861371917 0.390803926548438 no 2044 0.35334736285182 3095 1357585
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.377396199577823 0.390459353233324 no 2045 0.35293959537319 3078 165521
SGTC_2916 7875993 68.79 µM -0.378658814737427 0.390062988021453 no 2046 0.352470620409688 3203 1299250
SGTC_2340 7987427 183.45 µM -0.380851317903631 0.389374980356598 no 2047 0.351656788774248 3206 2239331
SGTC_831 k061-1017 217 µM -0.380893052477045 0.389361887399283 no 2048 0.351641303964301 3147 1240153
SGTC_1668 st014914 51.6 µM -0.380994870187098 0.38932994570615 no 2049 0.351603527496128 3148 2839556
SGTC_1667 st014849 34.6 µM -0.381166860408808 0.3892759915763 no 2050 0.351539718908893 3097 5348460
SGTC_2104 5389443 200 µM -0.382638572382512 0.388814396091515 no 2051 0.350993883130996 3252 2244536
SGTC_2290 7904846 200 µM -0.383536979343189 0.388532692099009 no 2052 0.350660828522056 3146 2962154
SGTC_444 curcumin 90.4 µM -0.388659517211661 0.386927596024644 no 2053 0.348764016485526 3207 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1339 1486-1321 22.7 µM -0.390164200744784 0.386456484311633 no 2054 0.348207565847019 3110 3469382
SGTC_2649 anisomycin 9.56 µM -0.390531831728432 0.386341405606333 no 2055 0.348071660950832 3155 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1129 3453-1384 223 µM -0.391391299862654 0.386072407238036 no 2056 0.347754011087614 3275 1084452
SGTC_3043 9092303 49.47 µM -0.393067762347668 0.385547861738983 no 2057 0.347134716818642 3143 25236084
SGTC_48 0382-0018 55 µM -0.394377063764489 0.385138342125403 no 2058 0.34665133747231 3345 762596
SGTC_2593 nobiletin 86.24 µM -0.395438440382978 0.384806461697083 no 2059 0.346259672268845 3147 72344 An anti-infammatory.
SGTC_1353 1498-1206 8.11 µM -0.396337895163421 0.384525278437485 no 2060 0.345927887491424 3148 6756808
SGTC_1059 3448-6867 171 µM -0.396916228022267 0.384344514854509 no 2061 0.34571461843904 3175 3934407
SGTC_2197 6588183 93.1375 µM -0.398946308822375 0.383710192594575 no 2062 0.344966383102655 3095 884136
SGTC_2959 9079155 11 µM -0.39907912649396 0.383668703012907 no 2063 0.344917451023878 3248 16189457
SGTC_1434 4073-0095 163 µM -0.400948675417621 0.383084835072636 no 2064 0.344228955892056 3206 24133745
SGTC_1828 st055811 49 µM -0.401706185020319 0.382848337168122 no 2065 0.343950136060624 3223 5877589
SGTC_963 1269-2853 151 µM -0.402366644601277 0.382642174349577 no 2066 0.3437071070699 3099 3668223
SGTC_125 0133-0007 11.75 µM -0.402737790630332 0.382526335503663 no 2067 0.343570564980751 3255 26541
SGTC_2193 5925765 200 µM -0.402778897894571 0.382513506110936 no 2068 0.343555443154063 3195 877370
SGTC_2872 9044037 25.97 µM -0.405175768789113 0.381765676846137 no 2069 0.34267415751458 3102 6465195
SGTC_482 fipronil 114 µM -0.406680573045848 0.381296399616592 no 2070 0.342121305337571 3189 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_3034 9090421 49.47 µM -0.408064670201874 0.380864919242667 no 2071 0.341613098509318 3179 17173761
SGTC_52 0329-0193 875 nM -0.408663388704762 0.380678319763167 no 2072 0.341393352493333 3309 3739292
SGTC_2418 pentamidine 31.67 µM -0.408836304639726 0.380624433117178 no 2073 0.341329897632601 3219 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_130 0136-0219 337.655 µM -0.4101394536407 0.380218400927691 no 2074 0.34085182619654 3098 234244
SGTC_991 3996-0057 64.7 µM -0.410936917562816 0.379969993995961 no 2075 0.340559395635962 3188 715343
SGTC_788 1182-0090 188 µM -0.412455060078067 0.379497235389835 no 2076 0.340002956703014 3303 5715185
SGTC_2306 7482397 179.52 µM -0.412681667257823 0.379426683997871 no 2077 0.339919929095722 3279 891448
SGTC_2607 solasodine 47.35 µM -0.415057382204043 0.378687276112537 no 2078 0.339049948435898 3142 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1968 st069590 43.6 µM -0.415364193047079 0.378591817854279 no 2079 0.338937657530262 3232 6384066
SGTC_385 1494-0393 12.4 µM -0.416595873379666 0.378208678956663 no 2080 0.338487014120688 3161 3090647
SGTC_1632 st005650 90 µM -0.416753768499403 0.378159571159872 no 2081 0.338429260645372 3215 2759605
SGTC_89 0302-0250 142.109 µM -0.418369103274949 0.377657290544585 no 2082 0.337838636349428 3206 4203518 YLR208W SEC13
SGTC_2852 9023854 51.95 µM -0.419037212661555 0.377449605538526 no 2083 0.337594468182469 3290 19798528
SGTC_2038 4100038 30.985 µM -0.420821264064215 0.376895198392742 no 2084 0.336942801504678 3225 3596803
SGTC_1072 oxiconazole 14.9 nM -0.421061756636493 0.376820482932652 no 2085 0.336854993313331 3216 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_154 3389-1638 511.116 µM -0.421286702764985 0.376750601567079 no 2086 0.336772869457572 3194 5238686
SGTC_3153 9100258 49.47 µM -0.421711401941909 0.376618676283989 no 2087 0.336617840513668 3129 25236848
SGTC_454 lyso-paf C-16 6.67 µM -0.421953286327076 0.376543545619465 no 2088 0.336529557292724 3192 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_977 1348-1378 135 µM -0.423279167286701 0.376131802599526 no 2089 0.336045796012809 3107 X977
SGTC_1293 1000-1278 195 µM -0.42389689348702 0.375940020169299 no 2090 0.335820504908762 3272 678847
SGTC_2357 9067248 200 µM -0.426169656193979 0.375234670721173 no 2091 0.334992113241961 3232 9150235
SGTC_2757 clomiphene 4.22 µM -0.426308897135693 0.375191470977152 no 2092 0.33494138781353 3357 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_3212 9128307 49.47 µM -0.431706376373869 0.373518104985858 no 2093 0.332977416238206 3039 27243542
SGTC_1079 idarubicin 2.36 µM -0.432387674880964 0.373307052506632 no 2094 0.332729837248503 3263 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_75 0159-0059 199.013 µM -0.43361108139118 0.372928161376327 no 2095 0.332285443205275 3424 5377270
SGTC_466 geldanamycin 89.2 µM -0.435736760637011 0.372270127238174 no 2096 0.331513865581629 3184 5288382 HSP90 inhibitor.
SGTC_11 0438-0307 1.3 µM -0.436244426414137 0.372113027175362 no 2097 0.33132969896532 3267 4011476
SGTC_1878 temozolomide 1 mM -0.438989846759932 0.371263810640697 no 2098 0.330334446630915 3278 5394 DNA alkylating agent.
SGTC_31 0508-1974 57.237 µM -0.441048554311586 0.370627419588617 no 2099 0.329588923218461 3265 6810525
SGTC_1635 st007035 42.4 µM -0.442071666580309 0.370311284945262 no 2100 0.329218673286033 3263 3716403
SGTC_3136 9095672 49.47 µM -0.442124046519967 0.370295102259564 no 2101 0.329199722225469 3194 17217380
SGTC_1205 4161-2785 76 µM -0.443981169514961 0.369721496091086 no 2102 0.328528099114182 3264 3498106
SGTC_1407 3909-7909 12.3 µM -0.444493033411552 0.36956344851669 no 2103 0.328343082260927 3217 4411780
SGTC_952 1185-0122 232 µM -0.445987267942134 0.369102201741134 no 2104 0.327803221459421 3180 678600
SGTC_2967 9089538 49.85 µM -0.446847201759202 0.36883683902537 no 2105 0.327492693886929 3365 728216
SGTC_269 exalamide 29 µM -0.447533733590083 0.368625030441317 no 2106 0.327244868507009 3193 3316 A derivative of salicylamide.
SGTC_3059 1327-0034 3 µM -0.450420100687094 0.367734966629522 no 2107 0.326203776983003 3183 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1915 st067105 30.6 µM -0.451086518313214 0.367529565322236 no 2108 0.325963596964493 3280 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2707 st078556 66.6 µM -0.451368480468191 0.367442671168657 no 2109 0.325861998218165 3240 17250899
SGTC_3157 9099274 49.47 µM -0.451816341632208 0.367304664766577 no 2110 0.325700648061426 3330 17217662
SGTC_2759 disulfiram 3.38 µM -0.452920519195196 0.366964490671538 no 2111 0.325302987461322 3157 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_728 3030-5151 22.5 µM -0.455695006787537 0.366110190263979 no 2112 0.324304656547609 3202 3125388
SGTC_686 1319-0111 510 µM -0.455997642902463 0.366017044758477 no 2113 0.324195836598782 3359 4562600
SGTC_2057 5236571 38.335 µM -0.458001248854899 0.365400573262839 no 2114 0.323475772020502 3365 54684039 YBR257W POP4
SGTC_1905 st060207 84.5 µM -0.458317230135834 0.365303383513879 no 2115 0.323362273534979 3168 1948547
SGTC_957 1187-1561 14.1 µM -0.458392626021622 0.365280194471217 no 2116 0.323335194236155 3309 1538454
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.460367116752448 0.364673088242684 no 2117 0.322626366739498 3214 4174840
SGTC_2734 clemastine 41.6 µM -0.4608985161656 0.364509754160839 no 2118 0.322435708197347 3238 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_26 0302-0163 425.158 µM -0.464371961551425 0.363442742376044 no 2119 0.32119063739519 3262 3100915
SGTC_1334 1486-0610 236 µM -0.465966344959629 0.36295331581702 no 2120 0.32061979533129 3299 3742339
SGTC_2110 5483698 200 µM -0.466249657283858 0.362866371056275 no 2121 0.320518404462258 3241 2848765 YHR062C RPP1
SGTC_1931 st074438 57.1 µM -0.468759540333624 0.362096430699861 no 2122 0.319620761475808 3284 2787313
SGTC_3288 9119690 36.221 µM -0.468957218683743 0.36203581386038 no 2123 0.319550107909179 3240 17595618 YKL019W RAM2
SGTC_1214 0358-0031 63.7 µM -0.468959813370668 0.362035018238739 no 2124 0.319549180567981 3406 4301366
SGTC_2269 7935389 174.42 µM -0.468990363145457 0.36202565065555 no 2125 0.319538262162256 3283 97605
SGTC_1948 st076329 66.6 µM -0.470815883110386 0.361466035361713 no 2126 0.31888611057952 3264 24208413
SGTC_2368 9071271 200 µM -0.471309047037744 0.361314906153648 no 2127 0.318710027986314 3248 27209959
SGTC_431 k089-0097 107 µM -0.472804026157274 0.36085690477682 no 2128 0.318176500694068 3278 5499420
SGTC_2762 leflunomide 42.06 µM -0.477373671465174 0.359458188665645 no 2129 0.31654802947106 3266 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_573 3702-0553 84.7 µM -0.477940783206115 0.359284733082005 no 2130 0.316346176492939 3268 1222756
SGTC_1227 3909-8010 46.6 µM -0.479773281690413 0.358724447408079 no 2131 0.315694306635508 3231 15982272
SGTC_105 0111-0055 734.78 µM -0.481657029551167 0.358148808986006 no 2132 0.315024803105986 3305 5179370
SGTC_3225 9130819 49.47 µM -0.483605305015431 0.357553791159382 no 2133 0.314333004551761 3351 4547121
SGTC_898 1000-0849 28.3 µM -0.484063765660069 0.35741382411313 no 2134 0.314170307810601 3315 6751807
SGTC_492 tmb-8 126 µM -0.485566184405661 0.356955273408197 no 2135 0.313637388406819 3276 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_293 4049-0273 38.5 µM -0.486996301079775 0.356518981781766 no 2136 0.313130476117922 3269 1380311
SGTC_2241 6772625 37.8075 µM -0.488425138324654 0.356083267903134 no 2137 0.312624369777606 3336 2285411
SGTC_1260 0700-1617 7.75 µM -0.488508912245155 0.356057727459694 no 2138 0.312594707290205 3342 2853078
SGTC_1530 rhein 70.4 µM -0.489271281472072 0.355825331026082 no 2139 0.312324825061717 3327 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1709 st033179 39.1045 µM -0.490170609834123 0.355551253596872 no 2140 0.312006588070946 3265 573381
SGTC_2225 6654152 15.4 µM -0.491327279605221 0.355198859134136 no 2141 0.311597494287425 3313 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2048 5246248 200 µM -0.49168990606588 0.355088405750357 no 2142 0.311469287513134 3366 677046
SGTC_584 0986-0246 15.4 µM -0.493337298324035 0.354586775465931 no 2143 0.310887139098005 3385 53315 YDR232W HEM1
SGTC_1641 st009299 47.1 µM -0.494272621641227 0.354302082022794 no 2144 0.310556828957346 3344 4046054
SGTC_2750 bromebric acid 70.15 µM -0.494515020709712 0.354228313939044 no 2145 0.310471250442997 3383 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2746 daunorubicin 9.88 µM -0.496033691105971 0.353766269229014 no 2146 0.309935320450146 3276 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_529 4076-0302 30.3 µM -0.496173378051374 0.353723781268613 no 2147 0.309886045988759 3266 5816522
SGTC_3114 9122766 49.47 µM -0.496517268305982 0.353619189455886 no 2148 0.309764753522907 3313 17176985
SGTC_257 daunorubicin 18.5 µM -0.496988609883188 0.353475852168954 no 2149 0.309598541741515 3373 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2798 7813637 45.45 µM -0.497484772053585 0.35332498926451 no 2150 0.309423619397775 3376 956368
SGTC_632 0781-2353 4.65 µM -0.500425527198638 0.352431297994108 no 2151 0.308387741294558 3356 6811515 YHR007C ERG11
SGTC_2797 7859098 81.82 µM -0.50141841537326 0.352129744278601 no 2152 0.308038341059866 3267 972681
SGTC_1715 st032160 10.2275 µM -0.502332355454492 0.351852250336454 no 2153 0.307716876596993 3341 5289825
SGTC_2738 aclarubicin 5.55 µM -0.502806398870822 0.351708350546505 no 2154 0.307550197167547 3282 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_999 SEC7.066 22.7 µM -0.504867903641648 0.351082811068189 no 2155 0.306825809382593 3275 740511 YDR170C SEC7
SGTC_2089 5281248 129.67 µM -0.505542893045973 0.350878081000837 no 2156 0.306588789934117 3337 2737878
SGTC_2840 9008771 71.43 µM -0.506222230651754 0.350672075792219 no 2157 0.306350325283579 3308 2992978
SGTC_1138 3761-0006 1.03 µM -0.507762793699536 0.350205071681357 no 2158 0.305809852688086 3380 12061087
SGTC_3070 9117005 49.47 µM -0.50826909949715 0.350051640253459 no 2159 0.305632318679589 3394 8779016
SGTC_268 camptothecin 39.6153 µM -0.508739764323797 0.349909031453187 no 2160 0.305467322998011 3383 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2723 salbutamol 83.58 µM -0.508925261356801 0.349852832708102 no 2161 0.305402306237544 3360 9884233 β2-adrenoceptor agonist
SGTC_2552 juarezic acid 87.02 µM -0.509531367321153 0.349669227940432 no 2162 0.305189908731641 3359 1549512
SGTC_1814 st052110 31.539 µM -0.509663318658438 0.349629261214295 no 2163 0.305143677760803 3401 674163
SGTC_1809 st050081 57.6 µM -0.510504356836942 0.34937455843342 no 2164 0.304849081521143 3456 5036894
SGTC_1837 st055472 66.5 µM -0.5111216861874 0.349187647520255 no 2165 0.304632925782879 3458 676091
SGTC_3297 9117502 71.43 µM -0.511765496708188 0.348992757774275 no 2166 0.304407570398815 3367 7453720
SGTC_80 0159-0065 512.242 µM -0.512465149256994 0.348781009083966 no 2167 0.304162752600704 3365 1548079
SGTC_601 0986-0029 62.9 µM -0.513063349405715 0.348600002137247 no 2168 0.303953503949619 3352 24747981
SGTC_175 3793-3120 23.7 µM -0.513567405577407 0.348447508584903 no 2169 0.303777236430811 3280 5322297
SGTC_626 0214-0009 33 µM -0.514989458549485 0.348017422920922 no 2170 0.303280193146506 3401 3437874
SGTC_525 k781-2675 26.7 µM -0.516140318757957 0.347669499837324 no 2171 0.302878204921092 3413 3651118 YDL195W SEC31
SGTC_355 1311-2252 105 µM -0.516427146812529 0.347582807174804 no 2172 0.302778054833057 3314 5338538
SGTC_1288 0973-0013 65.5 µM -0.517185302488754 0.347353695962305 no 2173 0.302513405453348 3413 4315430
SGTC_981 1488-1094 54.9 µM -0.518312410622122 0.347013192079238 no 2174 0.302120157653853 3355 3449522
SGTC_127 0180-0333 59.125 µM -0.520203246670796 0.346442240400043 no 2175 0.301460961347254 3410 771601
SGTC_929 2805-0021 398 µM -0.52208671647185 0.34587385965821 no 2176 0.300804977407341 3392 3098024
SGTC_575 k072-0246 11.9 µM -0.522573382486412 0.34572705327504 no 2177 0.300635583772731 3378 6796779
SGTC_10 0279-0212 42.575 µM -0.524187659696182 0.345240260853381 no 2178 0.300074011550091 3374 39851 YBR002C RER2
SGTC_1610 st001799 48.1 µM -0.525838711854672 0.344742643509576 no 2179 0.299500137471267 3267 621897
SGTC_3160 9100216 49.47 µM -0.526089110455544 0.344667198280348 no 2180 0.299413147181667 3368 17191039
SGTC_1148 3909-7663 27.7 µM -0.527687031167462 0.344185889545109 no 2181 0.298858287986931 3455 4084526
SGTC_717 1532-0246 73.2 µM -0.528586079097237 0.343915198709878 no 2182 0.298546309672716 3373 9561992
SGTC_3168 9103419 49.47 µM -0.530758904429773 0.343261321667537 no 2183 0.297792930653124 3373 16649256
SGTC_3054 9094397 49.47 µM -0.530985357135286 0.34319320129709 no 2184 0.297714463118068 3339 2598354
SGTC_2324 6149169 200 µM -0.531494566182347 0.343040042190175 no 2185 0.297538052886436 3316 2888231
SGTC_1298 1079-1278 263 µM -0.533103698571108 0.342556219432066 no 2186 0.296980899473003 3399 2840950
SGTC_1882 5615643 20 µM -0.534566997680508 0.342116468936686 no 2187 0.296474654776146 3382 2253075
SGTC_3024 9090631 49.47 µM -0.536187557562083 0.341629708241279 no 2188 0.295914465932059 3408 25236383
SGTC_317 4495-0002 170 µM -0.537209367068182 0.341322926917661 no 2189 0.295561500835219 3390 15991618
SGTC_379 3970-0972 5.9 µM -0.538109996963857 0.341052614667907 no 2190 0.295250555576863 3394 2898042 YBL034C STU1
SGTC_1153 4055-0057 267 µM -0.540576755378539 0.340312667455977 no 2191 0.294399671556259 3342 882706
SGTC_1497 4476-2978 41.3 µM -0.543274149080814 0.339504240435958 no 2192 0.29347053014584 3438 1528379
SGTC_2212 7123476 200 µM -0.544880386978493 0.33902319043999 no 2193 0.292917893144754 3398 1085715
SGTC_1406 3909-7906 11.9 µM -0.545876921736915 0.338724871423198 no 2194 0.292575271583206 3436 X1406
SGTC_1116 jasmonic acid 1.58368 µM -0.546618571834798 0.338502919384514 no 2195 0.292320403595451 3472 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1243 0416-0003 5.65 µM -0.547018370268213 0.338383295823751 no 2196 0.292183055747285 3346 2141977
SGTC_322 k048-0136 19.3 µM -0.547199451587949 0.338329119905755 no 2197 0.292120856456575 3440 6823282
SGTC_2965 9082772 38.63 µM -0.548089100338603 0.338063003378179 no 2198 0.291815362181213 3495 16459634
SGTC_157 1348-1695 65.819 µM -0.548828517770353 0.337841886404703 no 2199 0.291561568783803 3448 5380510
SGTC_58 0957-0393 9 µM -0.549118887255233 0.337755068987182 no 2200 0.291461932180598 3448 6997992
SGTC_791 1348-1292 225 µM -0.550401764507043 0.337371605569926 no 2201 0.291021919345027 3463 5437054
SGTC_540 1187-0821 17.3 µM -0.550999278348919 0.337193060981139 no 2202 0.290817084632382 3356 847520
SGTC_1990 st072050 59.8 µM -0.551382518212361 0.337078563425819 no 2203 0.290685741027437 3345 17233948
SGTC_1622 st003707 19.4 µM -0.551791470134931 0.336956400725321 no 2204 0.290545616016943 3450 10140899
SGTC_516 3992-2719 87.3 µM -0.55484277655582 0.336045453683099 no 2205 0.289501102637074 3284 5350887 YDR037W KRS1
SGTC_563 tetrahydrosecaminediol 614 µM -0.555190213282922 0.335941789695962 no 2206 0.289382281135927 3479 334274 A psychoactive constituent of the cannabis plant.
SGTC_1175 0741-0056 27.6 µM -0.555572721372222 0.335827675970109 no 2207 0.289251491921515 3509 765927
SGTC_1686 st019653 115.5 µM -0.555651093638322 0.335804297021832 no 2208 0.289224697886551 3466 97252
SGTC_2783 7738165 71.43 µM -0.556419768554645 0.335575030068602 no 2209 0.288961963944226 3366 17201110
SGTC_1711 st032263 62.8 µM -0.556508995465451 0.335548420984087 no 2210 0.288931473362286 3400 3958979
SGTC_2345 9052315 157.45 µM -0.557939290137269 0.335121993799872 no 2211 0.288442920440159 3444 6469265
SGTC_2817 7995342 71.43 µM -0.558718393384247 0.33488980176074 no 2212 0.288176962154262 3310 18879975
SGTC_2705 st078069 42.8 µM -0.558828878213751 0.334856879655405 no 2213 0.288139255910402 3409 1530061
SGTC_818 4072-2707 53.5 µM -0.559978947976537 0.334514258981733 no 2214 0.287746898595292 3392 882871
SGTC_805 3852-0218 479 µM -0.559992528930347 0.334510213862288 no 2215 0.287742266831199 3354 6615355
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.561742651145997 0.333989096692252 no 2216 0.287145685216663 3423 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1714 st033236 13.627 µM -0.56332170257969 0.333519192140683 no 2217 0.286607921240391 3537 2916566
SGTC_2116 5511452 16.8835 µM -0.563958704344661 0.333329702813515 no 2218 0.286391118319525 3474 870744
SGTC_1560 lithocholic acid 53.1 µM -0.566044535081597 0.332709527229559 no 2219 0.2856817531674 3433 9903 A bile acid which acts as a detergent.
SGTC_1271 0832-2808 169 µM -0.566208387438674 0.332660828718804 no 2220 0.285626064445806 3501 3663794
SGTC_488 nitrendipine 139 µM -0.566389321023481 0.33260705678182 no 2221 0.285564576306532 3464 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1660 st012960 28.1 µM -0.567091442735761 0.332398424745352 no 2222 0.285326028224711 3430 24207266
SGTC_1627 st003713 25.6 µM -0.568620336240201 0.331944301194447 no 2223 0.284806910442429 3452 16195070 YER133W GLC7
SGTC_277 nystatin 15.5 µM -0.569789664683616 0.331597144880174 no 2224 0.284410183141587 3374 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2371 9071574 200 µM -0.570545229260695 0.331372905817956 no 2225 0.284153977285686 3467 45596039
SGTC_3351 9150312 21.596 µM -0.571340515019181 0.331136943455148 no 2226 0.283884421581889 3436 4904905
SGTC_188 3229-0966 278.469 µM -0.573021560989717 0.330638395557028 no 2227 0.283315047703768 3518 5722370
SGTC_2304 7443016 91.4 µM -0.57543106953575 0.329924331353933 no 2228 0.282499898264933 3441 939854
SGTC_1216 1165-0504 9.65 µM -0.576770476584696 0.329527662170524 no 2229 0.282047258014548 3510 6304004
SGTC_1758 st042942 75.2445 µM -0.579040569575043 0.328855805740307 no 2230 0.281280899571558 3473 669317
SGTC_807 1315-0151 48 µM -0.580170360105993 0.328521638901716 no 2231 0.28089986972567 3550 4011080
SGTC_690 glyoxal 20.3 µM -0.581220554959129 0.328211137633509 no 2232 0.280545907985213 3432 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_186 3455-3465 67.277 µM -0.582539696835316 0.327821287452363 no 2233 0.280101605373246 3458 755278
SGTC_1508 1080-0625 72.9 µM -0.583235615422718 0.327615695975499 no 2234 0.279867349234905 3450 767111
SGTC_944 3370-0224 231 µM -0.584143914574382 0.327347440667456 no 2235 0.279561745780846 3440 4580514
SGTC_923 1900-2434 73.3 µM -0.584162312500357 0.327342007980292 no 2236 0.279555557347401 3470 5910570
SGTC_2252 omeprazole 400 µM -0.584207548340559 0.327328650534028 no 2237 0.279540341839754 3432 4594 A proton pump inhibitor.
SGTC_3031 9088762 49.47 µM -0.586267837218966 0.326720513572026 no 2238 0.278847770496039 3435 205253
SGTC_276 colchicine 750 µM -0.586602528109035 0.326621766017228 no 2239 0.278735342189685 3541 2833 A microtubule depolymerizer.
SGTC_1723 st034307 2.5525 µM -0.58687894707847 0.326540220229044 no 2240 0.278642505043855 3479 867466
SGTC_2361 9034121 116 µM -0.588365922379119 0.326101693014358 no 2241 0.278143353033309 3438 6496917
SGTC_1934 st074720 32.6 µM -0.588469038839324 0.326071291613949 no 2242 0.278108754789222 3486 17250992
SGTC_340 k038-0059 454 µM -0.588581196480477 0.326038225951962 no 2243 0.278071125378248 3474 23733424
SGTC_2912 7964298 10.93 µM -0.588655438052202 0.326016339236909 no 2244 0.278046218351458 3500 2975850
SGTC_2813 7971799 71.43 µM -0.590497901350841 0.325473365801006 no 2245 0.277428446167993 3501 2234054
SGTC_1924 st058459 75.1 µM -0.591732301821422 0.325109795321245 no 2246 0.277014931256237 3480 688683
SGTC_1960 st011366 51.8 µM -0.593158921295921 0.324689817539965 no 2247 0.27653740056573 3518 3972846
SGTC_1942 st076330 65.2 µM -0.593244305619545 0.32466468859256 no 2248 0.276508832774303 3569 24208414
SGTC_377 3970-0964 33.1 µM -0.594645466914406 0.324252435303203 no 2249 0.276040240603651 3505 16481235
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.595336642693745 0.324049155068402 no 2250 0.27580923350233 3528 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1405 3909-7894 12 µM -0.595751948111979 0.323927035700523 no 2251 0.275670474427402 3524 7104060
SGTC_2167 5876490 200 µM -0.596658653448965 0.323660487452155 no 2252 0.275367651394464 3543 686534
SGTC_1804 st050076 49.1 µM -0.598604383456222 0.323088797845748 no 2253 0.27471836613298 3522 3895976
SGTC_1380 2291-0730 164 µM -0.599650485451597 0.322781607265005 no 2254 0.274369596807209 3463 2999191
SGTC_2943 9068529 45.32 µM -0.60043503280266 0.322551302203814 no 2255 0.274108173039268 3546 3270634
SGTC_112 phenothiazine 287.218 µM -0.603005425976673 0.321797236612686 no 2256 0.27325253979948 3524 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2415 st077333 57.7 µM -0.603122589295006 0.321762882348913 no 2257 0.273213569990702 3598 2766255
SGTC_2680 butyl paraben 22.24 µM -0.604392606064279 0.321390589810941 no 2258 0.272791325212408 3541 7184 An antifungal and steroid mimetic.
SGTC_68 0986-0284 82.829 µM -0.605678833298786 0.321013728141382 no 2259 0.272364021128565 3505 423278 YIL048W NEO1
SGTC_231 b-estradiol 524 µM -0.607156919300616 0.320580879877869 no 2260 0.271873389609025 3458 450 A steroid.
SGTC_2385 9074692 200 µM -0.607261020601834 0.320550403647898 no 2261 0.271838851111398 3485 17046906
SGTC_1489 4065-0444 182 µM -0.609749454863494 0.319822261291348 no 2262 0.271013894351067 3516 2877968
SGTC_2140 5586273 200 µM -0.609902148003084 0.3197776042164 no 2263 0.27096331476811 3522 854421
SGTC_2709 st078560 56 µM -0.61123508099254 0.319387881792112 no 2264 0.270521980991471 3576 17250903
SGTC_3321 9137793 26.8275 µM -0.611842861352484 0.319210245384703 no 2265 0.270320864345663 3538 4904192
SGTC_634 1611-4317 11.2 µM -0.612141527099849 0.319122969333721 no 2266 0.270222062203349 3567 2843522
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.612404166969214 0.319046229041952 no 2267 0.270135192770355 3518 688761
SGTC_1740 st038286 13.222 µM -0.617270180261757 0.317625842705282 no 2268 0.268528266100183 3560 716786
SGTC_2457 5731572 11.68 µM -0.618337756378387 0.317314575686106 no 2269 0.268176359214255 3571 2865357
SGTC_44 0929-0055 61.211 µM -0.618444037071023 0.317283595102628 no 2270 0.268141338439358 3467 1379590
SGTC_1036 k216-0215 33.5 µM -0.619010123344445 0.317118603797474 no 2271 0.267954844945724 3549 622330
SGTC_2320 7373003 200 µM -0.619011221038082 0.317118283899374 no 2272 0.267954483381052 3539 5415828
SGTC_2147 5545932 89.7195 µM -0.619907681356204 0.316857076370054 no 2273 0.267659284155494 3536 797404
SGTC_2453 5731132 22.18 µM -0.620206527607431 0.316770019852477 no 2274 0.267560912246136 3589 1362040
SGTC_2679 rapamycin 1 nM -0.622268361641738 0.316169666317162 no 2275 0.266882710672275 3551 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1397 3532-0190 20.1 µM -0.628013901448141 0.314499270597917 no 2276 0.264997416667097 3484 5322280
SGTC_574 1315-0397 40 µM -0.628330812060396 0.31440724545007 no 2277 0.264893625490503 3609 6794277
SGTC_295 k015-0027 31 µM -0.628620679820188 0.314323083158208 no 2278 0.264798709195182 3537 3887424
SGTC_757 1066-0008 322 µM -0.630616783000649 0.313743782449057 no 2279 0.264145561265442 3566 6842497
SGTC_2545 solidagenone 89.61 µM -0.633762090750057 0.312831896006336 no 2280 0.26311804837146 3420 6708572 An anti ulcer agent
SGTC_1225 1216-0074 20.6 µM -0.63527025209412 0.312395055894313 no 2281 0.262626085839416 3543 4241466
SGTC_2930 9013230 14.89 µM -0.635425221534896 0.312350183795196 no 2282 0.262575561457295 3560 2995857
SGTC_2187 6125751 200 µM -0.635636374912763 0.31228904786321 no 2283 0.26250672754418 3547 874498
SGTC_364 0083-0097 67.7 µM -0.636243863830055 0.312113188423889 no 2284 0.262308743692176 3584 5207356
SGTC_2587 piperic acid 92.2 µM -0.636992905615567 0.311896410366852 no 2285 0.262064732342477 3512 5370536
SGTC_2602 kawain 100 µM -0.637510094290805 0.311746770273175 no 2286 0.261896318470522 3572 5369129
SGTC_3174 9107204 49.47 µM -0.638815366911211 0.311369249194085 no 2287 0.261471525130531 3619 3938802
SGTC_2190 6049624 200 µM -0.639145630745263 0.311273759140649 no 2288 0.261364098806224 3532 2265554
SGTC_1614 st002383 48.6 µM -0.639206595710082 0.311256133567775 no 2289 0.261344270951233 3588 1947235
SGTC_3161 9100388 49.47 µM -0.639690175290379 0.311116341271767 no 2290 0.261187021998502 3603 25236368
SGTC_2788 5282734 71.43 µM -0.641432778335172 0.310612818875245 no 2291 0.260620771154979 3609 743706
SGTC_1496 4469-0713 57.4 µM -0.643029872366912 0.310151652428518 no 2292 0.260102358325248 3576 746691
SGTC_185 k048-0037 25.491 µM -0.644662118255967 0.309680644086808 no 2293 0.259573085116895 3609 6827589
SGTC_2201 6605497 169.863 µM -0.645970560477361 0.309303299504808 no 2294 0.259149210625366 3584 670741
SGTC_1164 k060-0068 93.7 µM -0.64612422439367 0.309258997207489 no 2295 0.259099454145407 3623 5963676
SGTC_555 4296-0685 37 µM -0.647148629171742 0.308963725595951 no 2296 0.258767877455255 3565 2908540 YHR072W ERG7
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.647502571960241 0.308861734775818 no 2297 0.258653365236325 3639 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.647604044801097 0.308832497462221 no 2298 0.25862054024986 3546 689007
SGTC_3075 9116269 49.47 µM -0.64858149682141 0.308550926810689 no 2299 0.258304459243336 3623 17015205 YNL244C SUI1
SGTC_1246 0422-0085 105 µM -0.648996714007767 0.308431350923966 no 2300 0.258170250075767 3600 264295
SGTC_391 gliotoxin 8.33 µM -0.64954406624992 0.308273753309228 no 2301 0.257993386621905 3630 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_3261 9137475 49.47 µM -0.649930782415475 0.308162428493102 no 2302 0.257868466675359 3477 17027690
SGTC_3165 9101544 49.47 µM -0.651329141073325 0.307760027290759 no 2303 0.257417020484648 3595 5002184
SGTC_1370 2001-0092 44.6 µM -0.653433881639972 0.307154788656816 no 2304 0.256738300916661 3679 790957
SGTC_1939 st074455 53.6 µM -0.654925851917565 0.306726075926401 no 2305 0.256257747388065 3631 1644229
SGTC_3015 9080845 49.47 µM -0.655611731131466 0.306529079428506 no 2306 0.256036987771821 3629 5296973
SGTC_2623 humulene 100 µM -0.655797037979081 0.306475865650764 no 2307 0.25597736125234 3557 6187145 An anti-inflammatory.
SGTC_2690 usnic acid 100 µM -0.655993751995975 0.306419380589798 no 2308 0.255914072155759 3672 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1247 0448-0043 5.84 µM -0.656376010653179 0.306309630830214 no 2309 0.25579111085761 3623 3089013 YGL099W LSG1
SGTC_2592 piperlongumine 83.33 µM -0.657378328793643 0.306021939174345 no 2310 0.255468841286829 3556 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2172 5754775 163.918 µM -0.657731222786523 0.305920677782763 no 2311 0.255355427832328 3532 2263357
SGTC_3023 9089636 49.47 µM -0.657910004997302 0.305869382667757 no 2312 0.255297980656086 3687 17249241
SGTC_1788 fluconazole 20 µM -0.659013751631326 0.305552786683294 no 2313 0.254943469038291 3591 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.659113047663843 0.305524311974311 no 2314 0.254911588848731 3637 688788
SGTC_2134 5324836 1.464 µM -0.660460105068013 0.305138138219667 no 2315 0.254479306027532 3569 699272
SGTC_2684 capsaicin 100 µM -0.660526322250533 0.305119160698782 no 2316 0.25445806624818 3626 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_316 k060-0003 58.6 µM -0.66208343489086 0.304673050949832 no 2317 0.253958875715237 3632 6152314
SGTC_821 1114-0266 29.2 µM -0.662266007807179 0.304620763166715 no 2318 0.253900378835211 3609 3123235
SGTC_1126 isoteolin 1.0172 µM -0.662347253803404 0.304597496086276 no 2319 0.253874349661551 3599 133323
SGTC_824 1304-0008 100 µM -0.66437090268216 0.304018222466459 no 2320 0.253226475634737 3633 768245
SGTC_2377 9073351 62.6 µM -0.664725298751308 0.3039168264217 no 2321 0.253113104762255 3582 7337946 YHR072W ERG7
SGTC_1796 st049173 110.4 µM -0.664811494919172 0.303892167168553 no 2322 0.253085534749814 3578 94134
SGTC_2928 9011484 9.79 µM -0.666072293770373 0.303531576163241 no 2323 0.252682446395072 3609 2994751
SGTC_2014 4013930 200 µM -0.666969929434358 0.303274967070167 no 2324 0.25239567065449 3600 64556
SGTC_590 k048-0076 22.4 µM -0.668764689024235 0.302762186207869 no 2325 0.251822797466499 3626 6832814
SGTC_1815 st051655 58.2 µM -0.669356531077189 0.302593176161519 no 2326 0.251634036741894 3603 5984156
SGTC_2915 7971052 15.16 µM -0.670309209227063 0.302321212394953 no 2327 0.251330348840931 3510 5741558
SGTC_1345 1488-0192 31.4 µM -0.671529928981217 0.301972890394375 no 2328 0.25094149994542 3645 658348
SGTC_3137 9097352 49.47 µM -0.672447993193216 0.301711047410202 no 2329 0.250649269057607 3720 44120435
SGTC_2669 eugenol 100 µM -0.673371347267055 0.301447798713749 no 2330 0.250355536258323 3608 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1498 4478-3555 97.6 µM -0.6756099300433 0.300810007214952 no 2331 0.249644167603272 3615 3437919
SGTC_1880 MG-132 525 µM -0.676215545624702 0.300637566802729 no 2332 0.249451901979213 3582 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_924 2046-0044 21.3 µM -0.676296456983488 0.300614531825076 no 2333 0.249426220897609 3652 3623589
SGTC_585 0kpi-0023 191 µM -0.677491059166604 0.300274528531036 no 2334 0.249047220458947 3593 64601
SGTC_2299 7976368 114.88 µM -0.677774946387212 0.300193755160133 no 2335 0.248957199252433 3631 2979718
SGTC_702 1488-0190 94 µM -0.678068249315628 0.300110313093 no 2336 0.248864210496793 3640 949357
SGTC_2563 tomatine 8.54 µM -0.678163726425466 0.300083152970195 no 2337 0.248833944424729 3640 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_3300 9124615 50.48 µM -0.678702718303124 0.299929848224823 no 2338 0.248663121730422 3663 24824903
SGTC_353 1988-1175 58.3 µM -0.680073257071714 0.299540187453103 no 2339 0.248229038361906 3520 2788357
SGTC_3194 9111903 49.47 µM -0.680101222027665 0.299532239066479 no 2340 0.248220185380422 3652 17087251
SGTC_1313 1220-0047 237 µM -0.680539471884373 0.299407689253938 no 2341 0.248081468812443 3666 3528706
SGTC_2924 9010168 62.78 µM -0.681760829444572 0.29906070564153 no 2342 0.247695098239314 3680 2993929
SGTC_2122 5258151 111.688 µM -0.683218446688915 0.298646840574676 no 2343 0.247234408995794 3644 2173356
SGTC_500 h-89 112 µM -0.686118609627805 0.297824165313964 no 2344 0.246319158325723 3679 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2553 4-methylesculetin 85.09 µM -0.686790863074516 0.297633618066081 no 2345 0.246107264182283 3681 5319502
SGTC_101 0490-5701 117.494 µM -0.689797591332584 0.296782056060256 no 2346 0.245160741811076 3572 4661669
SGTC_2743 auranofin 4.32 µM -0.689832305612987 0.296772230838918 no 2347 0.245149825148743 3606 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1630 st005209 31.3 µM -0.691537880496535 0.296289683584559 no 2348 0.244613792022146 3661 3367314
SGTC_2128 5255449 168.493 µM -0.692723068394099 0.29595457808301 no 2349 0.24424167970228 3684 736008
SGTC_556 4058-0063 51.5 µM -0.695627235163918 0.295134177090323 no 2350 0.243331152735791 3728 6615692
SGTC_246 cycloheximide 667 µM -0.695910180845184 0.29505430349516 no 2351 0.243242540552438 3562 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_458 nppb 133 µM -0.696252402714184 0.294957709951427 no 2352 0.243135387720805 3701 4549 A chloride channel blocker.
SGTC_879 0831-1030 162 µM -0.696552082491272 0.294873136057929 no 2353 0.243041576176882 3697 1549252
SGTC_3011 9081274 71.4286 µM -0.698108381357431 0.294434106241854 no 2354 0.242554708464465 3675 6625322
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.700202652328625 0.293843791923273 no 2355 0.241900377724846 3677 688667
SGTC_3197 9113331 49.47 µM -0.700366428999601 0.293797651114501 no 2356 0.241849248002194 3692 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2857 9024691 58.44 µM -0.700681688701311 0.293708842422772 no 2357 0.241750843039645 3706 16478292
SGTC_1066 ketoconazole 628 nM -0.701705772008781 0.293420443808769 no 2358 0.241431336328713 3709 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2060 5238662 140 µM -0.70242111179975 0.293219070279137 no 2359 0.241208291543982 3646 790130
SGTC_1190 1486-1332 13 µM -0.703434079809586 0.292934021823416 no 2360 0.240892637199976 3674 4150046
SGTC_871 0574-0004 149 µM -0.703838959646725 0.29282012491674 no 2361 0.240766534126996 3659 9551173
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.704358420176147 0.292674025387895 no 2362 0.240604796601514 3676 521171
SGTC_916 4466-0038 42 nM -0.704453391931031 0.292647318013899 no 2363 0.240575232904489 3734 5722064 YGL116W CDC20
SGTC_3092 9117248 49.47 µM -0.705197719060423 0.292438042124437 no 2364 0.240343600291551 3732 17141857
SGTC_1360 1598-0022 39.8 µM -0.705610476836702 0.292322020658542 no 2365 0.24021520356262 3725 761525
SGTC_2909 7941780 10.49 µM -0.705684354579343 0.292301256733257 no 2366 0.240192226327934 3678 1243215
SGTC_3286 9117135 37.221 µM -0.705690812499547 0.292299441716186 no 2367 0.240190217861826 3666 3438150
SGTC_668 1682-0499 62.6 µM -0.705718767069326 0.292291585064304 no 2368 0.240181523867098 3718 682214
SGTC_3099 9120367 49.47 µM -0.70580893517543 0.292266243922805 no 2369 0.240153482356505 3713 24824940
SGTC_2568 diosmetin 100 µM -0.706088817260818 0.292187591449782 no 2370 0.240066452786319 3662 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1791 st048313 56.1 µM -0.706209668194227 0.292153632960994 no 2371 0.240028879402567 3625 1204976
SGTC_1561 5-methoxyflavone 52.9 µM -0.706479253002284 0.292077887639408 no 2372 0.239945075192617 3649 94525
SGTC_2182 6325192 200 µM -0.706641453334555 0.292032318569878 no 2373 0.239894660639279 3631 736248
SGTC_1444 4112-3581 28 µM -0.706920653936546 0.291953886830898 no 2374 0.239807893995174 3716 2877249
SGTC_2327 6189656 200 µM -0.707435786809002 0.29180920384231 no 2375 0.239647852069602 3736 5349088
SGTC_990 3985-0011 41.3 µM -0.709288396370403 0.291289146256619 no 2376 0.239072763842754 3673 5399565 YGL099W LSG1
SGTC_1993 st073995 70.8 µM -0.709727597814318 0.291165918743378 no 2377 0.238936537356373 3697 3098394
SGTC_856 0433-0016 11.3 µM -0.710126628975493 0.291053982984802 no 2378 0.238812807238813 3704 3911780
SGTC_2784 7567673 72.73 µM -0.710384381718125 0.290981689171884 no 2379 0.238732902849408 3709 3471247
SGTC_1294 1000-1494 117 µM -0.712512509374795 0.290385118370516 no 2380 0.238073733971237 3686 712797 YDL207W GLE1
SGTC_869 0564-0080 44.1 µM -0.71491516473651 0.289712279195723 no 2381 0.237330732939278 3728 6843321
SGTC_1064 honokiol 6.76 µM -0.715307133068795 0.289602581907358 no 2382 0.237209640945296 3712 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_609 0986-0026 86.3 µM -0.715583696279906 0.289525193934827 no 2383 0.237124221839162 3689 2848610
SGTC_321 4534-3890 65.3 µM -0.715832807023958 0.289455496031166 no 2384 0.237047296150957 3723 699746
SGTC_1361 1608-0041 5.61 µM -0.716975887850664 0.289135778172923 no 2385 0.23669448736702 3678 X1361
SGTC_2069 5228469 200 µM -0.717121703387923 0.289095005748428 no 2386 0.236649502580369 3676 2835210
SGTC_612 0302-0167 22.4 µM -0.717413549220815 0.289013408972223 no 2387 0.236559480881979 3726 235821
SGTC_394 menadione 8.33 µM -0.717993104833463 0.288851403940599 no 2388 0.236380769153547 3665 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2902 5787006 60.46 µM -0.719068718723013 0.288550847484712 no 2389 0.236049289992349 3677 591003
SGTC_2693 st077581 40.7 µM -0.720713310494841 0.288091587869126 no 2390 0.235542960643085 3746 25238761
SGTC_287 k060-0039 29.6 µM -0.720975302660266 0.288018457248678 no 2391 0.235462355068668 3734 5861974
SGTC_2589 lobaric acid 100 µM -0.721319552817451 0.287922379043748 no 2392 0.235356464811046 3710 73157 A novel microtubule depolymerizer.
SGTC_1850 st056238 17 µM -0.721611477642185 0.287840916392664 no 2393 0.235266690259944 3714 5393177
SGTC_2874 9043904 71.43 µM -0.72203817263075 0.287721865240713 no 2394 0.235135504364097 3697 4463428
SGTC_735 3076-0345 636 µM -0.722077780153963 0.28771081562019 no 2395 0.235123329217783 3740 2888990
SGTC_2923 7992654 58.14 µM -0.72223295894397 0.287667526111319 no 2396 0.235075631420727 3741 2985126
SGTC_2443 5493264 126.67 µM -0.723631061145793 0.287277642877814 no 2397 0.234646133410691 3736 5340055
SGTC_2570 licareol 100 µM -0.7243481387837 0.287077771334767 no 2398 0.234426015116545 3715 443158
SGTC_2871 9038510 12.99 µM -0.724855719038414 0.286936332955548 no 2399 0.234270274436016 3713 4945164
SGTC_2491 paeonol 100 µM -0.72524284705505 0.286828481059896 no 2400 0.234151530584712 3634 11092 Increases levels of cortical cytochrome oxidase.
SGTC_153 4077-0274 519.67 µM -0.726265715605474 0.286543607569786 no 2401 0.233837946332449 3777 3121976
SGTC_2334 9017922 200 µM -0.727676537764642 0.28615090763371 no 2402 0.233405807968786 3763 3163164
SGTC_3243 9134147 49.47 µM -0.728137225474199 0.286022731389001 no 2403 0.233264794185089 3764 24282180
SGTC_2755 lomerizine 42.69 µM -0.728779455949049 0.285844090398882 no 2404 0.233068290159804 3726 3949 A calcium channel blocker.
SGTC_1583 clindamycin 39.6 µM -0.729956583701399 0.285516801720531 no 2405 0.232708361722066 3689 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_254 nsc-64875 3.808 µM -0.731095365651151 0.285200344579908 no 2406 0.232360452410522 3741 56993
SGTC_663 1486-0733 13.9 µM -0.731422581926814 0.285109445078471 no 2407 0.232260538095682 3737 722445 YPR165W RHO1
SGTC_2249 haloperidol 116.36 µM -0.732399167118564 0.284838235380788 no 2408 0.231962483501205 3714 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1682 st012968 530 nM -0.732523898022782 0.284803604943931 no 2409 0.231924430872454 3732 24207270
SGTC_1757 st041620 31.8375 µM -0.733262117161717 0.284598686046242 no 2410 0.231699287796611 3770 5289815
SGTC_835 0312-0010 67.2 µM -0.733366381330239 0.284569749504256 no 2411 0.231667498986866 3691 1626196
SGTC_800 3448-7362 155 µM -0.733538593383309 0.284521958392975 no 2412 0.231614999060095 3800 15991913
SGTC_1127 asiatic acid 681.4 nM -0.734290618732713 0.284313306394337 no 2413 0.231385817125091 3718 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_342 k048-0088 23.3 µM -0.735477355743926 0.283984191005636 no 2414 0.231024412919516 3723 6820570
SGTC_564 3555-0129 330 µM -0.736174139894849 0.283791038232814 no 2415 0.230812363921284 3635 563260
SGTC_2214 7179297 48.276 µM -0.736418193543704 0.283723399965159 no 2416 0.230738117950061 3752 769744
SGTC_234 nsc-17383 10.7 µM -0.736596249594578 0.283674057478388 no 2417 0.230683958178229 3741 408974
SGTC_151 3013-0144 2.285 µM -0.738119642794865 0.283252066331504 no 2418 0.230220874139531 3715 906558 YHR107C CDC12
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.739048062192542 0.282995035068582 no 2419 0.229938906597613 3732 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1978 st071761 42 µM -0.740230375818547 0.282667875812145 no 2420 0.229580109568147 3762 5147680
SGTC_3314 9135860 59.4275 µM -0.740761388557016 0.282520997887428 no 2421 0.229419065120978 3707 25252478
SGTC_3259 9138485 49.47 µM -0.74097449379039 0.282462063379627 no 2422 0.229354452813562 3845 17646153
SGTC_3230 9131665 49.47 µM -0.74141356793362 0.282340655541674 no 2423 0.229221360169519 3666 15943720
SGTC_1266 0828-0227 32.9 µM -0.741531776947456 0.282307974006061 no 2424 0.229185535922119 3766 3913820
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.742184458658395 0.282127558271931 no 2425 0.228987791715454 3725 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_137 0438-0332 85.389 µM -0.742690839177371 0.281987621690092 no 2426 0.228834438626857 3761 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_672 1441-0018 53.7 µM -0.744762527139319 0.281415466002237 no 2427 0.228207646034773 3744 251141
SGTC_1377 2944-0135 198 µM -0.745377727580823 0.281245668806872 no 2428 0.228021702165831 3813 1894137
SGTC_1051 3253-3903 78 µM -0.747345253956905 0.28070295786111 no 2429 0.227427591241049 3753 5509239
SGTC_1581 himbacine 57.9 µM -0.749654933485896 0.280066516446843 no 2430 0.22673127826621 3756 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1618 st003135 44.5 µM -0.75000528622212 0.279970036480302 no 2431 0.226625760500669 3679 1270615
SGTC_828 2074-0507 139 µM -0.750040884865898 0.279960234244992 no 2432 0.226615040602104 3806 X828
SGTC_1767 st044992 70.3 µM -0.750867165464609 0.279732761197734 no 2433 0.226366301327947 3782 9600693
SGTC_3069 9117009 49.47 µM -0.750923295209833 0.279717312068431 no 2434 0.226349409912466 3681 41904981
SGTC_1237 0330-0133 46.1 µM -0.751362085406587 0.279596553896319 no 2435 0.226217387040531 3699 X1237 YHR072W ERG7
SGTC_2987 9018338 71.43 µM -0.751601038844661 0.279530802861729 no 2436 0.22614550920783 3813 5055682
SGTC_576 1073-0113 22.7 µM -0.751605436579965 0.27952959284008 no 2437 0.226144186478259 3901 5439563
SGTC_3088 9117578 49.47 µM -0.754736242966978 0.278668808304042 no 2438 0.225203627820865 3811 678341
SGTC_2138 5575593 77.673 µM -0.754964240179474 0.278606173156411 no 2439 0.225135219434469 3748 762213
SGTC_3051 9093778 49.47 µM -0.7561476525596 0.278281177579849 no 2440 0.224780337044265 3780 17217378
SGTC_3274 9138298 49.47 µM -0.75753382697387 0.277900733503706 no 2441 0.224365053929553 3737 17015756
SGTC_705 1124-0212 310 µM -0.757807640004933 0.277825613874319 no 2442 0.224283073996343 3733 9554485
SGTC_2065 5221596 34.26 µM -0.757827625654685 0.27782013127076 no 2443 0.224277090936072 3752 788581
SGTC_2678 equilin 100 µM -0.757923501624482 0.277793830637104 no 2444 0.224248390016689 3764 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1615 st002656 86.5 µM -0.758413539292512 0.277659422812651 no 2445 0.224101727525083 3771 1584458
SGTC_1031 k035-0009 16 µM -0.760319781399225 0.277136879931052 no 2446 0.223531730216018 3834 5180959
SGTC_3060 1327-0027 12.5 µM -0.760378872451754 0.277120689466494 no 2447 0.223514074220153 3710 16000455 YPR107C YTH1
SGTC_2375 9072683 200 µM -0.763272429027809 0.276328445392515 no 2448 0.222650470649734 3816 16798029
SGTC_2312 7706453 155.7 µM -0.763692854995438 0.276213426980321 no 2449 0.222525149831233 3814 976098
SGTC_3062 9077494 49.47 µM -0.765378972135342 0.27575238216633 no 2450 0.222022955353677 3756 16459633
SGTC_3200 9114385 49.47 µM -0.767801855090822 0.275090542125369 no 2451 0.221302456122158 3788 17018030 YLR208W SEC13
SGTC_2362 9071156 126 µM -0.76795726989539 0.275048115391388 no 2452 0.221256285687258 3788 653133
SGTC_2966 9084041 48.03 µM -0.768425571217589 0.274920293165034 no 2453 0.221117196637558 3737 17741380
SGTC_1211 1056-0033 32.3 µM -0.768791734844585 0.274820369683494 no 2454 0.221008478119869 3772 6741922
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.773218724880512 0.273613693800592 no 2455 0.219696473113448 3776 77254
SGTC_1296 1068-0102 11.9 µM -0.773412140031109 0.273561033974786 no 2456 0.219639253770467 3802 767053
SGTC_474 dl-dihydrosphingosine 5 µM -0.773734448180908 0.273473292474625 no 2457 0.219543922134328 3794 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_3196 9111891 49.47 µM -0.774364815005359 0.273301728866658 no 2458 0.219357542254601 3796 18891510
SGTC_1681 tripelennamine 100 µM -0.774833646491048 0.273174164055981 no 2459 0.219218982333235 3771 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2641 levomentholum 100 µM -0.774925082930155 0.273149288465641 no 2460 0.21919196478666 3761 16666
SGTC_1652 st011932 78 µM -0.775382026598047 0.273024992229932 no 2461 0.219056976222506 3730 1551076
SGTC_1657 st012939 43.4 µM -0.77572835100566 0.272930804945147 no 2462 0.21895469823546 3799 24207257
SGTC_506 n9-isopropylolomoucine 153 µM -0.777188447152817 0.272533890651489 no 2463 0.218523798609955 3768 6610355
SGTC_3095 9117207 49.47 µM -0.779490202510412 0.271908761267747 no 2464 0.21784550337885 3791 17015229
SGTC_18 0111-0177 500 nM -0.781276830647236 0.271424026524634 no 2465 0.217319847067727 3868 721752
SGTC_969 1313-0238 134 µM -0.783016188132026 0.27095253086047 no 2466 0.216808802961937 3812 5212874
SGTC_165 k038-0023 64.381 µM -0.783447633295448 0.270835640314904 no 2467 0.216682146832789 3800 46368543
SGTC_1794 st048918 76.9 µM -0.785036508934021 0.270405386663389 no 2468 0.216216081644784 3714 672303
SGTC_419 nsc-638432 893 µM -0.789731856262134 0.269135927271652 no 2469 0.214842191441374 3792 368090
SGTC_2880 9042983 58.44 µM -0.79097487354786 0.268800359714702 no 2470 0.214479327038095 3846 6464714
SGTC_625 k213-0058 121 µM -0.791907883344857 0.26854862057013 no 2471 0.214207194987992 3875 3655420
SGTC_2239 6685329 187.64 µM -0.793480128207771 0.268124675107008 no 2472 0.213749071275985 3892 805680
SGTC_1362 1611-0397 101 µM -0.793523943394954 0.268112865456731 no 2473 0.213736312501587 3797 27816
SGTC_3281 9140613 49.47 µM -0.793754945607132 0.268050607006285 no 2474 0.213669053089253 3818 16013766
SGTC_2101 5377231 179.231 µM -0.793784116061038 0.268042745662966 no 2475 0.213660560594721 3864 2844213
SGTC_2303 7774051 200 µM -0.794713034579477 0.267792465830642 no 2476 0.213390224202698 3777 2953184
SGTC_3280 9140961 49.47 µM -0.795803967876017 0.267498684534811 no 2477 0.213072992556885 3863 4901226
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.796905692945433 0.267202162114438 no 2478 0.212752902169774 3861 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1569 carminic acid 40.6 µM -0.798038325739414 0.266897494114852 no 2479 0.212424124826873 3882 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2997 9067075 71.4286 µM -0.798572081962479 0.266753979370801 no 2480 0.21226929059283 3860 27209819
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.798591761146627 0.26674868883743 no 2481 0.212263583234034 3819 6708760
SGTC_1258 0671-0043 57.1 µM -0.798805932985582 0.266691114510956 no 2482 0.212201474897693 3855 4298767
SGTC_1970 st070122 35.8 µM -0.798994322168586 0.266640476350077 no 2483 0.212146852134467 3829 102928
SGTC_984 1492-0255 2.91 µM -0.800110729994709 0.266340490767884 no 2484 0.211823322460094 3805 1585198
SGTC_211 3455-0679 143.504 µM -0.802742021520345 0.265634123001765 no 2485 0.211061929707985 3878 748649
SGTC_926 2268-1401 59.4 µM -0.803793576159743 0.265352100067332 no 2486 0.210758100165328 3811 2931578
SGTC_2520 obtusaquinone 4.71 µM -0.804213035263508 0.265239645155525 no 2487 0.210636975920018 3849 5967872
SGTC_3180 9109287 49.47 µM -0.804391701105668 0.265191753075966 no 2488 0.210585396251483 3877 18891271
SGTC_3139 9095020 49.47 µM -0.804440132683757 0.265178771558092 no 2489 0.210571415646316 3591 25236292
SGTC_1328 1441-0025 69.2 µM -0.805154903396707 0.264987223163253 no 2490 0.210365148171739 3798 4562601
SGTC_2093 5331342 194.4 µM -0.80555630117709 0.264879685095995 no 2491 0.210249365426635 3877 33839
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.805700171670019 0.264841146300716 no 2492 0.210207875254669 3870 23665772 A membrane-active detergent.
SGTC_527 4476-4215 268 µM -0.80685137041753 0.264532875727155 no 2493 0.209876059385019 3844 4418754
SGTC_2483 5729050 27.16 µM -0.808562628654626 0.264074968819693 no 2494 0.209383384095094 3835 2865180
SGTC_3006 9075424 71.4286 µM -0.808645249911238 0.264052870841101 no 2495 0.20935961447514 3816 7465181
SGTC_74 000s-0487 160.283 µM -0.809369778942263 0.263859127821353 no 2496 0.209151240023092 3765 677548
SGTC_2425 5628681 7.85 µM -0.810000830645482 0.263690440221467 no 2497 0.208969849170006 3918 5714958
SGTC_176 1486-1328 72.834 µM -0.816653921724547 0.261915343562632 no 2498 0.207063115414307 3917 22310231
SGTC_2337 9009472 200 µM -0.816965180711419 0.26183244752678 no 2499 0.206974163328342 3816 5742383
SGTC_2946 9065502 71.43 µM -0.819611042102963 0.261128332402473 no 2500 0.20621893840776 3691 16489101
SGTC_3336 9143619 71.43 µM -0.820067189100244 0.26100704125206 no 2501 0.206088902776926 3855 45595730
SGTC_1996 st072960 66.8 µM -0.820515765660367 0.260887791364661 no 2502 0.205961072710009 3824 1719405
SGTC_1526 st051518 75 µM -0.821695025219707 0.26057442995235 no 2503 0.205625245611036 3867 673993
SGTC_1811 st050069 61.5 µM -0.821769270831857 0.260554707355114 no 2504 0.205604112981162 3799 3877702
SGTC_740 k014-0057 261 µM -0.822561511239559 0.260344304554312 no 2505 0.20537869680082 3870 4012779
SGTC_3155 9099265 49.47 µM -0.82415684101054 0.2599208834398 no 2506 0.204925223219398 3890 25236499
SGTC_383 2324-0395 7.37 µM -0.824997795007233 0.259697826451236 no 2507 0.204686421271519 3891 3146421
SGTC_3228 9131799 49.47 µM -0.825414292173335 0.25958739017375 no 2508 0.204568211754874 3879 17015818
SGTC_1846 st056244 14.8 µM -0.827148455121607 0.259127829112346 no 2509 0.204076461439684 3899 5393182
SGTC_2426 5582046 32.21 µM -0.827506454445547 0.259033010071295 no 2510 0.203975032626513 3867 2251934
SGTC_2115 tiliquinol 12.7705 µM -0.827939688756246 0.25891828843001 no 2511 0.2038523283214 3867 71208 A bioactive hydroxyquinoline.
SGTC_2246 7293507 91.5585 µM -0.828926636761607 0.258657040050114 no 2512 0.20357296083797 3924 887656
SGTC_2100 5377183 190 µM -0.829269653933008 0.258566274245449 no 2513 0.203475919203645 3897 2844202
SGTC_2957 9076800 11.52 µM -0.83022755843175 0.258312890421414 no 2514 0.20320506839031 3853 16459615
SGTC_3347 9188721 44.724 µM -0.831517453623051 0.257971892207165 no 2515 0.20284068625775 3926 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_759 3486-0358 89.3 µM -0.831972705221827 0.257851597132721 no 2516 0.202712175610866 3851 875103
SGTC_2523 spermine 47.74 µM -0.832177690651986 0.257797441562167 no 2517 0.202654327210436 3889 1103 A DNA binding polyamine.
SGTC_1457 k015-0032 57.3 µM -0.835517373196556 0.256915955446345 no 2518 0.201713234642275 3880 4302660
SGTC_659 k018-0002 107 µM -0.83553021098781 0.256912570028534 no 2519 0.201709622125395 3863 6797879 YHR007C ERG11
SGTC_2608 thymoquinone 42.66 µM -0.835731498557332 0.256859492085297 no 2520 0.201652985459473 3859 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_230 MPP+ 141.667 µM -0.835893632795677 0.256816742716464 no 2521 0.201607372368053 3889 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1184 1269-1718 139 µM -0.836218904970462 0.256730990505206 no 2522 0.201515882455962 3959 5403821
SGTC_864 0469-0573 172 µM -0.836464774903296 0.256666181173563 no 2523 0.201446742672873 3871 689425
SGTC_1000 4048-0884 8.67 µM -0.837132054979602 0.256490334469202 no 2524 0.201259172031228 3908 13040088
SGTC_1720 st037298 9.481 µM -0.83887101215593 0.256032366373424 no 2525 0.200770848073825 3909 597396
SGTC_505 gw-5074 63.9 µM -0.841981621587717 0.255214228036054 no 2526 0.19989912038115 3937 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1700 st030840 7.9285 µM -0.843824058913201 0.25473028396483 no 2527 0.199383864602852 3945 5499307
SGTC_1976 st070609 63.5 µM -0.844145722094549 0.254645843551126 no 2528 0.199293990377639 3804 682556
SGTC_760 0568-0725 82.9 µM -0.844384735820425 0.254583109098049 no 2529 0.199227224605345 3933 3916171
SGTC_605 1315-0399 119 µM -0.844446405897085 0.254566923732756 no 2530 0.199209999955805 3975 24020461
SGTC_1215 3852-0577 11.2 µM -0.84522763221039 0.25436193688091 no 2531 0.19899187860854 3964 2884876
SGTC_429 1112-0049 25.5 µM -0.845899588835237 0.254185690662715 no 2532 0.198804380952578 3872 2836170
SGTC_3278 9139605 49.47 µM -0.846144978497954 0.254121343844868 no 2533 0.19873593584868 3936 7958859
SGTC_2367 9070478 135.38 µM -0.846368552588503 0.254062725011351 no 2534 0.198673588006082 3852 572802
SGTC_1484 3473-2379 286 µM -0.848366153141806 0.253539289628422 no 2535 0.198117043178315 4003 671917
SGTC_2591 skatole 100 µM -0.849552008183922 0.253228825806953 no 2536 0.197787101786538 3957 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_1171 0368-0077 21.4 µM -0.84969235002368 0.253192096721917 no 2537 0.197748076348067 3858 3239779
SGTC_723 4182-0001 115 µM -0.849992380970958 0.253113584545728 no 2538 0.197664661104471 3897 744821 YLR208W SEC13
SGTC_1676 st018489 23.4 µM -0.851448845029506 0.25273263869906 no 2539 0.197260034142463 3945 3696235
SGTC_3262 9137218 49.47 µM -0.852639483023669 0.252421445488255 no 2540 0.196929630061262 3715 17650664
SGTC_2521 angolensin 13.4 µM -0.85419575497051 0.252014992411098 no 2541 0.196498267439712 3992 821428 A flavenoid.
SGTC_2261 9010538 184.68 µM -0.854988030763695 0.251808205691124 no 2542 0.196278887005997 3904 6457250
SGTC_633 0437-0093 97.7 µM -0.855284518430124 0.251730844426007 no 2543 0.19619682804199 3855 2831118
SGTC_2763 lisinopril 49.32 µM -0.855296816216946 0.251727635887931 no 2544 0.196193424829903 3820 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1896 st058441 89 µM -0.858753902098355 0.250826526406538 no 2545 0.195238152574706 3939 688759
SGTC_2218 6965428 192.983 µM -0.859648201194203 0.25059370049126 no 2546 0.194991498089297 3822 675684
SGTC_1119 parthenolide 318.541 nM -0.861216201929372 0.25018575651984 no 2547 0.194559489131694 4044 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2477 5967686 25.23 µM -0.862113068085052 0.249952578882496 no 2548 0.194312650422482 3913 776118
SGTC_1688 st021091 57.6 µM -0.862207097467144 0.249928138717703 no 2549 0.194286782368474 3919 3656366
SGTC_749 1000-0129 128 µM -0.862422885884897 0.249872055678034 no 2550 0.194227425593108 3975 708470
SGTC_3039 9090270 49.47 µM -0.862740557110096 0.24978950562897 no 2551 0.194140064081284 3898 17173750
SGTC_1176 0848-0131 83.3 µM -0.863823684879934 0.249508152918226 no 2552 0.193842377360243 3976 6769040
SGTC_1035 k081-0041 55.2 µM -0.864557448418124 0.249317646601277 no 2553 0.193640868043948 3900 731709
SGTC_1456 k015-0012 13 µM -0.865516706626143 0.249068711998446 no 2554 0.193377625146553 3921 2989616
SGTC_1736 st036774 51 µM -0.867966645908456 0.248433535228202 no 2555 0.192706296127338 4010 1272247
SGTC_2806 7952793 58.44 µM -0.868556275595742 0.248280795496245 no 2556 0.1925449394709 3993 2972490
SGTC_844 0330-0132 15.3 µM -0.86875062382641 0.248230461825779 no 2557 0.192491772699048 3970 2828079
SGTC_63 0099-0242 26.702 µM -0.869376595256488 0.248068380339913 no 2558 0.192320590168845 3969 3898502 YLR359W ADE13
SGTC_2995 9067767 71.4286 µM -0.869759751454193 0.247969198362112 no 2559 0.19221585554131 3973 11673567
SGTC_2084 5306078 60.6385 µM -0.870593039156333 0.24775357057347 no 2560 0.191988199262232 3874 679340
SGTC_746 1095-0025 46.6 µM -0.870782438871518 0.247704574047511 no 2561 0.191936477813014 3952 6749286
SGTC_849 0386-0493 241 µM -0.871106558043422 0.247620738443545 no 2562 0.191847986838075 3886 726119
SGTC_1075 aripiprazole 15.2 µM -0.873524088938485 0.246995906212931 no 2563 0.191188741071403 3961 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1379 2144-0755 36.5 µM -0.874394774028728 0.246771076758867 no 2564 0.190951651199117 4023 5392327
SGTC_3067 9117431 49.47 µM -0.875507850384379 0.246483816358026 no 2565 0.190648820316138 3988 17150885
SGTC_2082 5219693 150 µM -0.875537701894287 0.24647611481106 no 2566 0.190640702778815 3915 2834649
SGTC_696 1560-0013 611 µM -0.878750835202933 0.245647896162501 no 2567 0.189768194465386 3990 1650269
SGTC_1239 0337-0584 35.4 µM -0.879687379316077 0.245406773752537 no 2568 0.189514344104192 4023 914301 YML130C ERO1
SGTC_2458 5808907 16.39 µM -0.881396345778833 0.244967111684899 no 2569 0.189051667415948 4070 2731747
SGTC_2008 4012253 172 µM -0.881503273929373 0.244939616608339 no 2570 0.189022741391158 3946 603940
SGTC_1154 4088-0362 150 µM -0.881543269001856 0.244929332862239 no 2571 0.189011922691504 3935 6618304
SGTC_1203 3992-3522 103 µM -0.881892166777224 0.24483963226185 no 2572 0.18891756173694 4079 5322312
SGTC_3325 9138760 55.175 µM -0.881991504727133 0.244814095998836 no 2573 0.18889070065588 3890 43844959
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.882216964004977 0.244756143736051 no 2574 0.18882974497344 3962 91467 include heat shock
SGTC_2298 7976326 193.81 µM -0.887648786984876 0.243362177844169 no 2575 0.187364850944835 3822 2235818
SGTC_2920 7982904 15.77 µM -0.887723607101901 0.243343006797081 no 2576 0.187344722079574 3962 6456808
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.888101690287021 0.243246143589418 no 2577 0.187243026761277 4001 6710655
SGTC_2157 5649910 96.377 µM -0.888397444486492 0.24317038722767 no 2578 0.187163499766482 3937 2858091
SGTC_2310 7668677 200 µM -0.888879900302192 0.243046835308319 no 2579 0.187033814373602 3953 2197143
SGTC_3146 9095609 49.47 µM -0.889353586135582 0.242925562329579 no 2580 0.186906540471127 4008 17173999
SGTC_2741 miltefosine 3.04 µM -0.889990174320667 0.242762634690095 no 2581 0.186735581021565 3921 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_795 0685-0265 78 µM -0.890019257252422 0.242755192651419 no 2582 0.186727772944382 3984 302754
SGTC_2878 9043973 25.97 µM -0.892777273053776 0.242050004739669 no 2583 0.185988229701891 4040 6465167
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.894836078419213 0.241524320646271 no 2584 0.185437360488696 3961 688662
SGTC_1355 1499-0035 1.68 µM -0.894937562426469 0.241498424319174 no 2585 0.185410232893625 3954 1548538
SGTC_1468 k284-1086 134 µM -0.895421647748678 0.241374917908 no 2586 0.185280866404294 3959 15996457
SGTC_343 4130-2827 29.8 µM -0.896498019371475 0.241100422406878 no 2587 0.184993418827783 4000 1118244
SGTC_3126 9127922 49.47 µM -0.896502477460052 0.241099285861429 no 2588 0.184992228861203 4020 45595682
SGTC_670 4204-0025 119 µM -0.896938729512927 0.240988081819453 no 2589 0.184875806139007 3974 719039
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.897688829117744 0.240796940827731 no 2590 0.184675733307641 3922 140250 A respiratory chain inhibitor.
SGTC_1877 wortmannin 25 µM -0.900596416433811 0.240056807286871 no 2591 0.18390147032515 3979 312145 A covalent inhibitor of PI 3-kinase.
SGTC_754 3474-0146 171 µM -0.901079145975442 0.239934047452534 no 2592 0.183773119972799 3937 24762078
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.901622015584251 0.239796034696354 no 2593 0.183628845984286 3969 3256 An antibiotic and ribosome inhibitor.
SGTC_225 nsc-122657 1.016 µM -0.901874622207369 0.239731829741303 no 2594 0.183561736869047 3976 275685
SGTC_2831 7999036 19.48 µM -0.90209104723582 0.239676828514233 no 2595 0.183504252150509 4041 2988270
SGTC_1263 0774-1208 64.8 µM -0.902344616653247 0.239612396350877 no 2596 0.183436915775594 3990 906585
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.902676682297694 0.239528032542128 no 2597 0.183348757709985 3965 75037 A free radical scavenger.
SGTC_826 1683-5028 118 µM -0.903029718204348 0.239438358866643 no 2598 0.18325506135519 4032 722377
SGTC_67 0335-0847 266 µM -0.903264660697617 0.239378691934429 no 2599 0.183192723752501 4145 4552207 YOR254C SEC63
SGTC_682 0kpi-0099 17 µM -0.903649053416633 0.239281087542419 no 2600 0.183090760849085 4020 1714895 YML126C ERG13
SGTC_1286 0929-0070 131 µM -0.904628997144563 0.239032360174019 no 2601 0.182830984017984 4069 1420408
SGTC_903 1134-0042 114 µM -0.907759995243886 0.238238604547388 no 2602 0.182002519279271 4001 701009
SGTC_1683 st010134 710 nM -0.908188201079433 0.238130160214742 no 2603 0.181889398398517 3971 3818134
SGTC_406 estrone 100 µM -0.909726913858089 0.237740700210847 no 2604 0.181483273389221 3959 5870 A steroid.
SGTC_1326 1431-2094 10.8 µM -0.909986161985714 0.237675116932413 no 2605 0.181414903833666 3969 616278
SGTC_1318 1280-3875 124 µM -0.911912807566776 0.237188035013056 no 2606 0.180907309441812 4006 373245
SGTC_865 0488-0499 301 µM -0.913296494995871 0.236838558828195 no 2607 0.180543312635645 3990 9634651
SGTC_336 4111-0029 111 µM -0.914517244725466 0.236530470844008 no 2608 0.180222560373992 3990 3131175
SGTC_219 mitoxanthrone 164.414 µM -0.915338637531483 0.236323295163843 no 2609 0.180006940646177 3957 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_645 0845-0943 5.41 µM -0.915783089098782 0.236211235103442 no 2610 0.1798903374474 3992 1885106
SGTC_1285 0929-0069 65.5 µM -0.91776343128988 0.235712285137946 no 2611 0.179371365532428 4018 1206237
SGTC_2742 clothiapine 36.27 µM -0.918798136533275 0.23545182106713 no 2612 0.179100583676541 3942 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_822 1487-0950 154 µM -0.920134561355598 0.235115640975166 no 2613 0.178751222751775 4021 1958375
SGTC_2884 9058502 51.95 µM -0.921533631688754 0.234763986527153 no 2614 0.178385945380965 4024 6471554
SGTC_56 0957-0365 83.25 µM -0.922241953623366 0.234586061690915 no 2615 0.178201192045652 3993 6752360
SGTC_199 4063-0024 41.6 µM -0.922484264677857 0.234525212206766 no 2616 0.178138017158702 4014 306215
SGTC_2532 xanthone 78.9 µM -0.922818596250133 0.234441268740485 no 2617 0.178050874035003 4011 7020 An insecticide.
SGTC_1766 st045414 44.774 µM -0.923028110606881 0.234388672666563 no 2618 0.177996278070271 4029 253960
SGTC_2118 5526350 200 µM -0.923388442573486 0.234298230908998 no 2619 0.177902406230901 4049 743594
SGTC_1427 4048-4900 550 nM -0.923569021276638 0.23425291370605 no 2620 0.177855374537896 3991 24132586
SGTC_3305 9127027 53.8275 µM -0.923911173182592 0.234167062141307 no 2621 0.177766282640647 3927 41905295
SGTC_2086 5274770 176.623 µM -0.924534940053495 0.234010593570355 no 2622 0.177603934340292 4063 689278
SGTC_1453 4237-0541 195 µM -0.925006575841339 0.233892324723667 no 2623 0.177481243458016 3987 739892
SGTC_745 0469-0705 296 µM -0.925311257858195 0.233815939332215 no 2624 0.177402012221573 4088 3486736
SGTC_1254 0550-0035 264 µM -0.925921509083276 0.233662987709906 no 2625 0.177243386204682 4082 15121435
SGTC_1125 tnp00248 1.32998 µM -0.927365743443151 0.233301230020371 no 2626 0.1768683352654 4103 24207736
SGTC_1189 1431-2119 7.28 µM -0.927427818324031 0.233285688221565 no 2627 0.17685222638843 4013 3107275
SGTC_1727 st034309 9.9045 µM -0.927823735895371 0.2331865751522 no 2628 0.176749504758131 4107 870305
SGTC_344 k064-0035 6.43 µM -0.928496616335513 0.233018181486488 no 2629 0.176575011087472 3964 5088750
SGTC_2174 5790901 200 µM -0.93170670937869 0.232215760526279 no 2630 0.175744059065113 4034 786020
SGTC_2711 st079103 59.1 µM -0.932641160684657 0.23198246676616 no 2631 0.175502636964105 3965 54693780
SGTC_2504 purpurogallin 52.29 µM -0.933505776026644 0.23176672444173 no 2632 0.175279444798228 3916 5281571 An antioxidant.
SGTC_554 4483-2211 187 µM -0.935721516960847 0.231214354397085 no 2633 0.174708294587635 4057 747107
SGTC_446 go6976 132 µM -0.936301886950822 0.231069793350101 no 2634 0.174558888454165 4033 3501 A protein kinase C inhibitor.
SGTC_3296 9122258 64.045 µM -0.936437008219638 0.23103614400564 no 2635 0.174524115487732 4020 4730474
SGTC_862 0452-0056 10.2 µM -0.938106113797725 0.230620711110136 no 2636 0.174094940109223 3973 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2487 5918373 44.05 µM -0.939193203154924 0.230350364051542 no 2637 0.173815779030215 4081 2876279
SGTC_722 3534-0461 190 µM -0.940359525904251 0.230060509678534 no 2638 0.173516587845873 4071 658262
SGTC_2434 5670830 169.91 µM -0.943382165743632 0.229310274273131 no 2639 0.172742730981863 4067 1549830
SGTC_1611 st001856 99.4 µM -0.943450076616851 0.229293434199618 no 2640 0.172725369733179 4000 647478
SGTC_1309 pyrazolanthrone 13.4 µM -0.943522036267088 0.229275590894709 no 2641 0.172706974638309 4012 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2611 pyromycin 23.93 µM -0.944793901614701 0.228960344317052 no 2642 0.172382052946888 4014 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_432 NS 1619 61.3 µM -0.944835687846361 0.228949991243232 no 2643 0.172371384496033 4069 4552 A K+/calcium channel activator.
SGTC_1202 1988-0068 29.6 µM -0.944868523716016 0.228941855920497 no 2644 0.172363001459356 3986 2850480
SGTC_2307 7538926 6.34 µM -0.945557968522523 0.228771078478282 no 2645 0.172187045440699 4037 96582
SGTC_2420 aureobasidin a 50 nM -0.947891484879691 0.228193590806179 no 2646 0.17159235014621 4160 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_644 1498-1197 63.3 µM -0.948867174278252 0.227952374967651 no 2647 0.171344085801891 4071 6741615
SGTC_302 1094-0063 18.9 µM -0.949326880937354 0.227838773236869 no 2648 0.171227192979096 3999 5440289
SGTC_2348 9022543 33.42 µM -0.951188060355067 0.227379168271099 no 2649 0.170754459158077 4084 3162678 YDL140C RPO21
SGTC_1529 apigenin 74 µM -0.951763246387382 0.227237235910787 no 2650 0.170608532810037 4061 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2462 5162487 171.77 µM -0.951841867663296 0.227217839278809 no 2651 0.170588592570811 3924 2259986
SGTC_848 0368-0089 85.6 µM -0.952841343785369 0.226971340163711 no 2652 0.170335231542806 4047 762535
SGTC_943 3253-1379 105 µM -0.952990874296244 0.226934474678473 no 2653 0.170297347220411 4053 668464
SGTC_2403 6032726 181.2 µM -0.95341569624457 0.226829756841579 no 2654 0.170189745853572 4103 2881040
SGTC_2485 5633444 17.78 µM -0.953802647704154 0.22673439773924 no 2655 0.170091774463547 4061 5724239
SGTC_1743 st037606 46.3785 µM -0.953870350821778 0.226717715521105 no 2656 0.170074636575933 4001 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1002 4049-0206 172 µM -0.95466272082435 0.226522525060283 no 2657 0.169874143921176 4038 4662749
SGTC_2445 5742597 35.57 µM -0.955665380058961 0.226275668513006 no 2658 0.169620659272025 3996 1774255
SGTC_1739 st037196 92.5 µM -0.956319126334625 0.226114796860177 no 2659 0.169455514880783 4120 612214
SGTC_620 0109-0052 432 µM -0.958352174062463 0.225614924697077 no 2660 0.168942601507072 4030 493037
SGTC_424 splitomicin 100 mM -0.95982849666105 0.225252328630122 no 2661 0.16857076886437 4125 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1514 1189-1591 158 µM -0.963413496588239 0.22437320062073 no 2662 0.16767002792677 4090 767698 YMR146C TIF34
SGTC_2670 beta-carotene 100 µM -0.963997267981308 0.224230230479348 no 2663 0.167523647793615 3972 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2801 7907800 81.82 µM -0.966721192890559 0.223563804356217 no 2664 0.166841714853734 4073 6620925
SGTC_214 4373-3496 70 µM -0.968411900389542 0.223150728894584 no 2665 0.166419349246474 4122 3779166
SGTC_936 3005-4620 401 µM -0.96925691975634 0.222944435832928 no 2666 0.166208508950814 4099 777207
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.970899481101604 0.222543751247568 no 2667 0.165799168298113 4043 5106787 A p450 inhibitor.
SGTC_739 1486-1183 203 µM -0.973135737701244 0.2219989019119 no 2668 0.165242922141036 4068 4346692
SGTC_2533 agelasine 13.65 µM -0.973594784108919 0.221887152538872 no 2669 0.165128888578673 4120 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2090 5301565 104.445 µM -0.974318829267862 0.221710957694379 no 2670 0.164949129176945 4069 2056344
SGTC_1117 retinoic acid 1.10837 µM -0.974512229104058 0.221663907788413 no 2671 0.16490113506234 4113 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1770 st043884 66.3 µM -0.97698011784793 0.221064026119205 no 2672 0.16428949776119 4066 670149
SGTC_596 1155-0152 116 µM -0.978049143039378 0.220804461640101 no 2673 0.16402500959381 4063 280313
SGTC_657 3534-0529 86.7 µM -0.982258557485827 0.219784093631013 no 2674 0.162986242831192 4131 1049549
SGTC_937 3122-0005 46.7 µM -0.982389285886229 0.219752448278977 no 2675 0.162954051306331 4103 759535
SGTC_1510 1123-0200 71.5 µM -0.983329475872328 0.219524934075472 no 2676 0.162722653773689 4139 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1018 4259-0013 28.1 µM -0.98431228976874 0.219287250126346 no 2677 0.162480994329185 4135 6801262
SGTC_1103 duloxetine 36.1 µM -0.984843468970785 0.219158851216461 no 2678 0.162350482468282 4160 60835 A selective serotonin reuptake inhibitor.
SGTC_3016 9080866 49.47 µM -0.984871972837628 0.219151962361947 no 2679 0.162343480937149 4055 17066299
SGTC_2461 5755302 26.15 µM -0.986788806575088 0.218688985063637 no 2680 0.161873091617007 4126 2788904
SGTC_2346 9031566 143.75 µM -0.989222257221989 0.218102039866463 no 2681 0.161277205515622 4039 4771086
SGTC_2536 dehydroabietamide 32.04 µM -0.989375464008509 0.218065116992626 no 2682 0.161239737265771 4172 3983547
SGTC_32 0928-0142 34.1 µM -0.989435048733876 0.21805075803216 no 2683 0.161225166759872 4068 2244242
SGTC_3340 9146634 11.102 µM -0.991320534593604 0.217596667853171 no 2684 0.160764544554432 4107 4907387
SGTC_346 4513-0042 7.16 µM -0.991572316613072 0.217536071368782 no 2685 0.160703099572579 4060 2827372
SGTC_638 3970-0837 4.09 µM -0.992363228996553 0.217345785517552 no 2686 0.160510184774617 4049 4118451 YLR208W SEC13
SGTC_2394 5221648 200 µM -0.993089640443642 0.21717110267438 no 2687 0.160333136016328 4140 788586
SGTC_1278 0874-0585 172 µM -0.996412706644575 0.216373027546246 no 2688 0.15952483082153 4143 766306
SGTC_1102 cgs 12066b 26.1 µM -0.996542293069483 0.216341940203572 no 2689 0.159493364248923 4082 6438352 A 5-HT1B full agonist.
SGTC_1491 4138-0063 26.5 µM -0.997232717371969 0.216176353349528 no 2690 0.159325781800865 4049 23883227
SGTC_1914 st062367 72.6 µM -0.999958616689468 0.215523308778147 no 2691 0.158665267688286 4078 978205
SGTC_3287 9117173 37.0625 µM -1.00049373790957 0.21539524410081 no 2692 0.158535813305218 4065 2789709
SGTC_974 1326-0144 138 µM -1.00188399407726 0.215062735795576 no 2693 0.158199811948859 4121 5411856
SGTC_2237 6667747 47.222 µM -1.00211731200829 0.215006962241903 no 2694 0.158143468788979 4092 729940 YDL015C TSC13
SGTC_1913 st060213 96.1 µM -1.00369572396751 0.214629870962925 no 2695 0.157762649385182 4141 688959
SGTC_392 N-ethylmaleimide 8.33 µM -1.00442113657948 0.214456694916286 no 2696 0.157587833136597 4031 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2629 bisabolol 100 µM -1.00537634020426 0.214228785374635 no 2697 0.157357834066149 4133 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1563 conessine 56.1 µM -1.00557350964878 0.214181758717866 no 2698 0.157310386034671 4163 441082 An anti-amoebic, histamine inhibitor.
SGTC_442 cape 100 µM -1.00597225880635 0.214086671874921 no 2699 0.157214457406255 4074 5281787
SGTC_2744 captopril 92.04 µM -1.00677739432259 0.213894751901348 no 2700 0.157020880103957 4126 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2279 7948423 32.93 µM -1.00819150940237 0.213557912192444 no 2701 0.156681266593596 4057 1247112
SGTC_1704 st028805 70.8 µM -1.011401499355 0.212794446442197 no 2702 0.15591215192583 4127 2876101
SGTC_2960 9079389 5.97 µM -1.01485873808437 0.211973959719399 no 2703 0.155086584733826 4104 16457355
SGTC_247 mechlorethamine 29.705 µM -1.01515377333309 0.211904026483808 no 2704 0.155016266055804 4000 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1412 3909-8563 178 µM -1.01545637551031 0.211832313655067 no 2705 0.154944165751404 4175 23767530
SGTC_2640 pentamidine 10.38 µM -1.01593631108917 0.211718604212539 no 2706 0.154829858064518 4099 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1399 3562-5772 25 µM -1.02027718010734 0.210691761251183 no 2707 0.153798511404254 4063 23847490
SGTC_362 0310-0100 9.03 µM -1.02117481044383 0.210479789773088 no 2708 0.153585812191497 4190 790235
SGTC_409 arachidonic acid 100 µM -1.02138999904074 0.210428992533745 no 2709 0.153534850845163 4109 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_455 paf C-16 10 µM -1.02161211803344 0.210376566859606 no 2710 0.153482259976664 4088 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_113 0099-0221 2.5 µM -1.02352377857584 0.209925683930527 no 2711 0.153030131487924 4039 89219
SGTC_2162 5663267 200 µM -1.02526220206412 0.209516154056848 no 2712 0.152619742724467 4104 6456493
SGTC_408 cantharidin 100 µM -1.02548802051913 0.209462991287309 no 2713 0.152566487506619 4076 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1056 3448-1962 115 µM -1.02597417759015 0.209348565860783 no 2714 0.152451877962067 4126 715507
SGTC_2935 9038016 29.96 µM -1.02695587397833 0.209117618906488 no 2715 0.152220621266931 4109 6463195
SGTC_3135 9127742 49.47 µM -1.02738746948072 0.209016132291691 no 2716 0.152119024729094 4210 3643468
SGTC_2985 9022375 71.43 µM -1.0307676448127 0.208222311838982 no 2717 0.151324897214506 4198 4939335
SGTC_606 k015-0008 38.6 µM -1.03176131930765 0.207989290190726 no 2718 0.151091971882995 4216 1970475
SGTC_2002 4023503 131 µM -1.03204166672266 0.207923575172182 no 2719 0.151026299353133 4128 4736863 YCR052W RSC6
SGTC_1195 1502-0147 41.1 µM -1.03285265961509 0.207733542896196 no 2720 0.15083642791792 4093 817940
SGTC_2699 st077704 54.6 µM -1.03409549982516 0.207442519104331 no 2721 0.150545759934351 4134 645852
SGTC_57 miconazole 162.5 nM -1.03432757723227 0.207388202512691 no 2722 0.150491524434052 4026 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2625 euphol 100 µM -1.03501512137903 0.207227335499426 no 2723 0.150330924705933 4160 6708538 A triterpene alcohol.
SGTC_610 4215-0184 155 µM -1.03693791008314 0.20677784611772 no 2724 0.149882397352294 4140 5605015
SGTC_21 0849-0113 22.993 µM -1.03706205160897 0.206748845463243 no 2725 0.149853469663137 4088 1560156
SGTC_1273 0849-0096 14.1 µM -1.03729896750397 0.206693506315083 no 2726 0.149798273415852 4151 5286025
SGTC_1691 st019933 84.6 µM -1.03820840454105 0.206481160201861 no 2727 0.149586520335504 4117 6176082
SGTC_347 4534-1311 26.2 µM -1.03902946154443 0.20628956116014 no 2728 0.149395517291778 4128 2862016
SGTC_1562 morin hydrate 59.1 µM -1.03964854462343 0.206145163764709 no 2729 0.149251607283032 4202 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_939 1165-0479 45.3 µM -1.04001232765387 0.206060341526045 no 2730 0.149167086672269 4123 1377347
SGTC_2686 alizarin 95.37 µM -1.04245943579816 0.205490294477991 no 2731 0.148599361378382 4125 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_338 4055-0136 114 µM -1.04286395172559 0.205396153884566 no 2732 0.148505653630415 4089 2900563
SGTC_2079 5212404 121 µM -1.04313213812831 0.205333754575751 no 2733 0.148443548954823 4108 758462
SGTC_2974 9094440 9.66 µM -1.0444171505369 0.205034925196987 no 2734 0.148146216058945 4164 25236134
SGTC_421 streptovitacin 30 mM -1.04498025187691 0.204904057593341 no 2735 0.148016048388532 4197 91467 include heat shock
SGTC_2382 9035899 200 µM -1.04514275031211 0.204866301369909 no 2736 0.147978499151152 4118 6462679
SGTC_1396 3511-0007 98.6 µM -1.04580384878118 0.204712738968453 no 2737 0.147825801923421 4151 X1396
SGTC_272 doxorubicin 8.13 µM -1.04655240305345 0.204538944690661 no 2738 0.147653031990367 4139 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2835 9006588 71.43 µM -1.04702395682878 0.204429507609273 no 2739 0.147544264567432 4203 2345538
SGTC_1111 tnp00062 510.699 nM -1.04865092221089 0.204052193001769 no 2740 0.147169404929285 4186 676306
SGTC_1946 st076057 65.1 µM -1.05296277228947 0.20305422725114 no 2741 0.14617902723875 4082 953009
SGTC_1229 0139-0193 12.2 µM -1.05306351040119 0.203030946587231 no 2742 0.146155942601898 4231 3090752
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.05328132280476 0.202980615403175 no 2743 0.14610603818291 4105 6708514
SGTC_1519 esterone 74 µM -1.05349274546464 0.202931767861809 no 2744 0.146057608708565 4113 698 A steroid.
SGTC_1559 coumarin 343 70.1 µM -1.05353571787097 0.202921840284193 no 2745 0.146047766564844 4180 108770 A hepatotoxic, DNA x-linker.
SGTC_2433 5607874 27.82 µM -1.05457101661701 0.202682751033937 no 2746 0.145810782588421 4114 2252428
SGTC_104 0074-0074 590.992 µM -1.0554015142888 0.202491079763598 no 2747 0.145620865312862 3932 3943124
SGTC_2727 riluzole 51.77 µM -1.0556296596302 0.202438444884307 no 2748 0.145568722425815 4160 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2049 5262831 67.185 µM -1.05706737292701 0.202106941661388 no 2749 0.145240420226066 4146 763417
SGTC_320 4092-0846 5.34 µM -1.05739844034431 0.202030651258715 no 2750 0.145164891520499 4110 1359356
SGTC_2842 9000675 19.48 µM -1.05892818470026 0.201678364407894 no 2751 0.144816243598577 4205 2989072
SGTC_771 0250-0039 27.3 µM -1.05921285345291 0.201612848293432 no 2752 0.144751426300205 4118 3005115
SGTC_2226 7298446 200 µM -1.05934552205655 0.201582319156356 no 2753 0.144721225162836 4139 3283010
SGTC_1464 k208-0027 110 µM -1.05955397926964 0.201534355460547 no 2754 0.144673779819253 4159 X1464
SGTC_3117 9124945 49.47 µM -1.06217677510396 0.200931463629837 no 2755 0.144077720632585 4057 17592065
SGTC_2899 9053889 58.44 µM -1.0624864740927 0.200860345833448 no 2756 0.144007447605044 4138 6470052
SGTC_1451 4152-0210 104 µM -1.06288560442325 0.200768713731494 no 2757 0.143916916031829 4199 659563
SGTC_671 0560-0003 407 µM -1.06652361434017 0.199934658743784 no 2758 0.143093504863555 4058 3238678
SGTC_2870 9038528 12.99 µM -1.06674687496008 0.199883541664322 no 2759 0.143043076898535 4207 6463316
SGTC_1096 rimcazole 32.2 µM -1.06823320973705 0.19954343530927 no 2760 0.142707663944389 4079 18528119 A dopamine reuptake inhibitor.
SGTC_1642 st009582 77.7 µM -1.07067920469126 0.198984496215699 no 2761 0.142156848136441 4162 6739311
SGTC_1177 0983-0204 23.6 µM -1.07181252982654 0.198725838037175 no 2762 0.141902122046953 4184 766818
SGTC_1507 4075-3230 155 µM -1.07366530408136 0.19830341725932 no 2763 0.141486358588776 4085 659771
SGTC_1574 spiramycin 23.7 µM -1.07399007848589 0.198229426617288 no 2764 0.141413564168073 4134 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1338 1486-1223 76 µM -1.07411401289065 0.198201196069747 no 2765 0.141385792399099 4182 3444526
SGTC_1843 st055809 45.5 µM -1.08276729403973 0.196236103503745 no 2766 0.139455862990217 4234 16413835
SGTC_205 1486-1330 71.903 µM -1.08285906182114 0.196215327261523 no 2767 0.139435492637439 4205 4118834
SGTC_803 4488-1585 147 µM -1.08299514036557 0.196184521509946 no 2768 0.139405290032848 4158 747204
SGTC_2795 7780010 54.55 µM -1.08402099636005 0.195952380444455 no 2769 0.139177744749344 4158 953673
SGTC_2158 5657123 3.6195 µM -1.08413962772185 0.195925546095062 no 2770 0.139151447422572 4138 2858827
SGTC_440 fluspirilene 35.1 µM -1.08653758989348 0.195383606509126 no 2771 0.138620609830203 4264 3396 An atypical antipsychotic.
SGTC_3292 9120825 59.784 µM -1.08853028369839 0.19493395109288 no 2772 0.138180537483234 4188 24824900
SGTC_1558 st069300 45.6 µM -1.08875144009748 0.194884085523903 no 2773 0.138131755446591 4120 24208000
SGTC_769 0302-0231 76 µM -1.08898640901941 0.194831114055833 no 2774 0.138079939551457 4098 571869 YER009W NTF2
SGTC_271 rotenone 740 µM -1.08990564729287 0.194623964845754 no 2775 0.137877354356743 4234 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3103 9120822 49.47 µM -1.09382036716856 0.193743289180962 no 2776 0.137016884805095 4207 17141819
SGTC_2259 7964009 200 µM -1.09971435576261 0.192421938458238 no 2777 0.135728298941855 4231 313134
SGTC_2143 5623677 140.463 µM -1.10078074495591 0.192183458751192 no 2778 0.135496046991401 4161 5375313
SGTC_2229 7354935 190 µM -1.10090550937174 0.192155569142691 no 2779 0.135468891997761 4119 318112
SGTC_1269 0831-0796 3.05 µM -1.10192900834146 0.19192687154716 no 2780 0.135246268078845 4224 927758
SGTC_1261 0712-0010 12.7 µM -1.10222429985971 0.191860920575437 no 2781 0.135182085099412 4219 2840123
SGTC_418 lividomycin a 100 µM -1.10313518224006 0.191657569784219 no 2782 0.134984232175323 4226 72394 An antibiotic.
SGTC_2030 5175110 200 µM -1.10525786231116 0.191184202567122 no 2783 0.134523935475217 4194 2831986
SGTC_1436 4092-1007 8.32 µM -1.11165918034824 0.18976102551076 no 2784 0.133142358444008 4202 2881121
SGTC_1554 st069299 38.7 µM -1.11332164448076 0.189392485587272 no 2785 0.132785156877976 4174 24207999
SGTC_3105 9121040 49.47 µM -1.1140526294505 0.189230578226854 no 2786 0.132628304538338 4089 41448907
SGTC_3066 9117245 49.47 µM -1.11473182522546 0.189080218162766 no 2787 0.132482679386407 4262 17176980
SGTC_2075 5212009 200 µM -1.11794808963945 0.188369202675614 no 2788 0.13179458228218 4131 780898
SGTC_2647 atorvastatin 60.16 µM -1.1181925576364 0.188315225973983 no 2789 0.131742381094263 4182 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2325 6158266 200 µM -1.1194291212729 0.188042348211691 no 2790 0.131478556573977 4224 3623240
SGTC_528 3492-0019 172 µM -1.1229452822309 0.187267756712242 no 2791 0.130730367091276 4211 2869262
SGTC_1871 st057448 67.3 µM -1.12384649868421 0.187069541611535 no 2792 0.130539075718449 4261 691747
SGTC_2238 6671620 73.2395 µM -1.126429420541 0.186502168675271 no 2793 0.129991899794675 4137 729941
SGTC_3127 9126946 49.47 µM -1.1272936527072 0.186312566855537 no 2794 0.129809172571438 4209 27243249
SGTC_973 1325-0077 65.9 µM -1.12741921750916 0.186285029434692 no 2795 0.129782638830218 4220 2835149
SGTC_2851 9015922 71.43 µM -1.12789914389562 0.186179800769622 no 2796 0.129681257740068 4249 2996893
SGTC_2807 7945238 51.95 µM -1.12923235154606 0.185887675007513 no 2797 0.129399914829284 4245 17148797
SGTC_85 0868-0259 160.055 µM -1.1316289244062 0.18536326521097 no 2798 0.128895237213658 4131 83173
SGTC_2412 st077135 33.4 µM -1.131729657041 0.185341243376415 no 2799 0.128874054567158 4295 13258915
SGTC_183 3914-0051 30.55 µM -1.13203947656781 0.185273521840436 no 2800 0.128808919042894 4255 1596232
SGTC_2785 7756463 72.73 µM -1.13574667892898 0.184464379701432 no 2801 0.128031299282296 4184 2201551
SGTC_689 0833-0039 98 µM -1.13647521113457 0.184305627468672 no 2802 0.12787886717997 4187 5374726
SGTC_1907 st060210 83.7 µM -1.13663932954286 0.184269876662465 no 2803 0.12784454580209 4272 688793
SGTC_1509 1326-1131 80 µM -1.13672896351537 0.184250353028509 no 2804 0.127825803737368 4185 768313
SGTC_2262 9014885 67.46 µM -1.13732574463454 0.184120397900212 no 2805 0.127701068139404 4211 6457424
SGTC_1527 coumarin 137 µM -1.13743004199194 0.184097691953632 no 2806 0.127679277221872 4304 323 A hepatotoxic, DNA x-linker.
SGTC_2919 7978188 46.38 µM -1.13750681736993 0.184080978764543 no 2807 0.127663238141902 4235 2980291
SGTC_569 4130-2812 160 µM -1.14009745889471 0.183517577236281 no 2808 0.127122850243589 4066 743552
SGTC_207 4185-0010 4.486 µM -1.14144837122812 0.183224213462686 no 2809 0.126841692602163 4300 3761753
SGTC_333 3486-0131 40.1 µM -1.14412818079975 0.182643132837473 no 2810 0.126285241081578 4268 6744690
SGTC_503 tyrphostin 8 294 µM -1.14443210254253 0.182577304230789 no 2811 0.126222240548376 4243 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_420 mitomycin C 81.9 mM -1.14685515703018 0.182053007465266 no 2812 0.125720744319216 4220 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2479 5617353 43.85 µM -1.14908308957057 0.181571762435259 no 2813 0.125260860311294 4279 2731746
SGTC_135 0933-0004 26.348 µM -1.1512480757712 0.181104877636507 no 2814 0.124815095999859 4218 21230617 YGL099W LSG1
SGTC_1009 4106-0057 9.87 µM -1.1536543679801 0.180586837935677 no 2815 0.124320949527592 4244 2928005
SGTC_54 0159-0055 9 µM -1.15386192513202 0.180542197479303 no 2816 0.124278390616063 4251 3319099
SGTC_2583 asiatic acid 100 µM -1.15390822689412 0.180532240049362 no 2817 0.124268897982331 4283 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1166 k206-0078 225 µM -1.15425401642596 0.180457887140442 no 2818 0.12419802139548 4266 5404595
SGTC_2102 5377816 72.7585 µM -1.15471622381902 0.180358531648933 no 2819 0.124103326772736 4302 1379702
SGTC_1077 5-fluorocytosine 377 nM -1.15503835446967 0.180289307169473 no 2820 0.124037360215678 4301 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_731 3966-0296 387 µM -1.1567259266487 0.17992692775805 no 2821 0.12369217679157 4248 660956
SGTC_2839 9003951 25.97 µM -1.15692958115052 0.179883227130649 no 2822 0.123650565931989 4298 2990634
SGTC_1270 0831-1170 17.3 µM -1.15738059600487 0.179786471110667 no 2823 0.123558449089751 4267 6764716
SGTC_2289 7946404 165.07 µM -1.15754392658141 0.179751439938464 no 2824 0.123525101741783 4248 1246120 YPR165W RHO1
SGTC_2513 baicalein 25.65 µM -1.15831944784514 0.179585164521021 no 2825 0.123366848905947 4256 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1409 3909-8004 61.9 µM -1.16004337567713 0.17921589266198 no 2826 0.123015573226676 4288 2119279
SGTC_2546 rhodinyl acetate 100 µM -1.16120285309655 0.178967797032963 no 2827 0.122779707388399 4203 6708682
SGTC_2078 5212016 200 µM -1.16209218520541 0.178777651450858 no 2828 0.122599010723572 4130 1899708
SGTC_607 4491-0986 66.8 µM -1.16415993956932 0.178336042565051 no 2829 0.122179600766178 4275 698981 YDR232W HEM1
SGTC_2950 9072895 21.46 µM -1.16673823386812 0.177786361779667 no 2830 0.121658048697278 4229 17332245
SGTC_3310 9130229 44.1445 µM -1.17192259776891 0.176684317905299 no 2831 0.120614066725404 4289 7761258
SGTC_1624 st003710 6.25 µM -1.17226840150607 0.176610964139702 no 2832 0.12054465686633 4302 24207033
SGTC_1494 4358-1428 177 µM -1.17628409488058 0.175760544231297 no 2833 0.119740684679287 4291 1564571
SGTC_1910 st062352 60.4 µM -1.17773829481309 0.175453223185738 no 2834 0.119450477529338 4160 2245730
SGTC_1951 sophoraflavanone G 9.2 µM -1.17907066267987 0.175171948530574 no 2835 0.119185019717566 4228 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_288 1315-0019 35.1 µM -1.18070376029696 0.174827577508076 no 2836 0.118860213593365 4320 6811474
SGTC_534 k292-0788 63.4 µM -1.18553417605644 0.173811505763188 no 2837 0.117903155177183 4320 4146317
SGTC_1276 0871-0068 94.2 µM -1.18736602802835 0.173427162312108 no 2838 0.117541636993099 4278 3414906
SGTC_1143 3454-2408 5.08 µM -1.18747118356209 0.173405115911816 no 2839 0.117520908265973 4275 X1143
SGTC_2859 9028643 45.46 µM -1.18907092758706 0.173069941359395 no 2840 0.117205878738953 4121 17151580
SGTC_1248 0469-0687 58.6 µM -1.18947620129181 0.172985094940289 no 2841 0.117126165289929 4258 4017482
SGTC_752 1896-0090 130 µM -1.19595735510523 0.17163182948806 no 2842 0.115856600569337 4275 772567
SGTC_193 1273-0060 1.558 µM -1.19670561857422 0.171476028685863 no 2843 0.115710658156556 4113 2847393 YHR072W ERG7
SGTC_1204 4049-0315 18.3 µM -1.20098091950727 0.170587574774843 no 2844 0.114879301426732 4336 588402
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -1.20200050909483 0.170376129011793 no 2845 0.114681665422198 4295 688798
SGTC_1038 k292-0204 154 µM -1.20410750565208 0.169939705454409 no 2846 0.114274014650129 4235 4454212
SGTC_3291 9121177 71.43 µM -1.20712872937139 0.169315169198252 no 2847 0.11369128616947 4268 17015612
SGTC_2712 st079126 47.7 µM -1.20978775003467 0.168766726746059 no 2848 0.113180173984508 4272 3152970
SGTC_817 1391-0715 46 µM -1.21319455402426 0.168065718781345 no 2849 0.112527722899039 4274 1353946
SGTC_2439 5492030 7.2 µM -1.21508109249218 0.167678338622676 no 2850 0.112167582072232 4295 5722370
SGTC_2970 9090938 41.86 µM -1.21566507603635 0.167558540598123 no 2851 0.112056266583432 4370 17217104
SGTC_3231 9132313 49.47 µM -1.21705174385271 0.167274301366874 no 2852 0.111792264628493 4244 4905967
SGTC_348 k064-0012 10.7 µM -1.21749813999446 0.167182865231195 no 2853 0.111707371844402 4228 5066323
SGTC_2973 9094665 17.96 µM -1.2183401104971 0.16701049059662 no 2854 0.111547376780462 4309 25237061 YIL048W NEO1
SGTC_1208 2323-2347 50.3 µM -1.22126260407407 0.166413065088658 no 2855 0.110993303773063 4299 5412760
SGTC_1475 4092-1048 11.7 µM -1.22144678198441 0.166375461125523 no 2856 0.110958451790682 4296 2881759
SGTC_2543 pimpinellin 60.67 µM -1.2223641958579 0.166188232686568 no 2857 0.110784966350634 4134 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3331 9141060 1.957 µM -1.22256687244508 0.16614688823276 no 2858 0.110746665886346 4258 4906567 YPR165W RHO1
SGTC_1555 citronellol 128 µM -1.22305360806647 0.166047625078625 no 2859 0.110654724604393 4270 8842 A terpine precursor.
SGTC_2129 girgensonine 121.053 µM -1.22349216589991 0.165958219957246 no 2860 0.110571930663166 4319 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1255 0566-0045 221 µM -1.22360864227487 0.165934480121183 no 2861 0.110549948922615 4324 2788469
SGTC_452 diindolylmethane 8 µM -1.22660567046283 0.165324390419986 no 2862 0.109985418455142 4297 3071 Inhibits expression of several cancer promoting factors.
SGTC_1699 st031318 29.054 µM -1.23029492547529 0.164575383289951 no 2863 0.109293341946434 4361 5340658
SGTC_2045 5106652 78.05 µM -1.23069860949094 0.16449355945063 no 2864 0.10921780417951 4278 673349
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.2331055900458 0.164006229271291 no 2865 0.108768186077968 4276 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1134 3477-0009 42.5 µM -1.23564346578962 0.163493412886407 no 2866 0.108295560228989 4375 3973534
SGTC_1461 k072-0203 53.8 µM -1.23599161812518 0.163423144727513 no 2867 0.108230839657634 4221 5418714
SGTC_3058 9093861 49.47 µM -1.23857706311805 0.16290193395562 no 2868 0.107751083360219 4333 17217477
SGTC_3249 9135183 49.47 µM -1.23923367526175 0.162769737034967 no 2869 0.107629486430619 4299 4902779
SGTC_253 dyclonine 31.25 µM -1.2404239673326 0.162530271293849 no 2870 0.107409310317756 4426 3180 An oral anasthetic.
SGTC_2620 irigenin 100 µM -1.24068406516322 0.162477974738598 no 2871 0.107361241573104 4346 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1327 1436-0082 2.18 µM -1.24345986072797 0.161920541676503 no 2872 0.106849211717245 4330 15992205
SGTC_3132 9126706 49.47 µM -1.24600471729073 0.161410581647648 no 2873 0.106381331673456 4368 850858
SGTC_3246 9135460 32.98 µM -1.25084178685092 0.160444179016409 no 2874 0.105496102949517 4303 41446951
SGTC_1388 3346-4487 254 µM -1.25189188389451 0.160234879627996 no 2875 0.105304631276555 4397 3345614
SGTC_2076 5212012 200 µM -1.25445345212421 0.15972507136529 no 2876 0.104838617268221 4299 604802
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.25505046021264 0.159606406326539 no 2877 0.104730221299292 4217 4000243
SGTC_1875 nocodazole 6 µM -1.25774081005614 0.159072371697423 no 2878 0.104242754022934 4357 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1724 st037281 8.293 µM -1.25978680791171 0.158667025543886 no 2879 0.103873139991183 4298 574124 YDL195W SEC31
SGTC_881 0833-0569 170 µM -1.26181921658051 0.158265042725055 no 2880 0.103506922880746 4355 5418700
SGTC_403 arphamenine a 50 µM -1.26212032361357 0.158205544732033 no 2881 0.103452746587877 4319 5487158 An arginine aminopeptidase inhibitor.
SGTC_608 k048-0125 159 µM -1.26375943475675 0.157881917965485 no 2882 0.103158192586612 4373 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_874 0599-0792 117 µM -1.2659168760486 0.157456615022291 no 2883 0.102771421885114 4352 765305
SGTC_2160 5660466 132.927 µM -1.26594497795949 0.157451080179805 no 2884 0.102766390936852 4266 2859134
SGTC_2696 st077691 74.316 µM -1.26598966674448 0.157442278714806 no 2885 0.102758390889894 4387 757133
SGTC_2772 vinpocetine 57.06 µM -1.26820946890437 0.157005495202136 no 2886 0.102361578226991 4352 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2423 st077119 87.2 µM -1.26821062592025 0.157005267747785 no 2887 0.102361371689374 4271 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_883 0850-0245 24.6 µM -1.26837611202698 0.156972737553265 no 2888 0.102331834070217 4409 6823229 YPR165W RHO1
SGTC_1755 st041960 45.185 µM -1.26911854964542 0.156826848512978 no 2889 0.102199392649798 4360 2257073
SGTC_2522 biochanin a 4.94 µM -1.27089244477218 0.156478639372905 no 2890 0.101883457297921 4354 5280373 A possible chelator.
SGTC_1556 plumbagin 1.48 µM -1.27128050179603 0.156402533113905 no 2891 0.101814438192469 4266 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2828 7998861 71.43 µM -1.27165866819249 0.156328390075329 no 2892 0.10174721096617 4332 2988188
SGTC_2437 5741531 144.16 µM -1.27599088586365 0.155480670464241 no 2893 0.100979370468285 4361 2262990
SGTC_648 0375-0473 33.3 µM -1.27617875377163 0.155443977592166 no 2894 0.100946168660267 4319 1713139
SGTC_1322 1348-1070 12 µM -1.282342636221 0.154243265941502 no 2895 0.0998612387801266 4347 6758089
SGTC_194 1486-1323 56.904 µM -1.28424764002385 0.153873419225004 no 2896 0.0995276604727073 4446 5178754
SGTC_775 4577-0580 57.3 µM -1.28427415429901 0.153868275759211 no 2897 0.0995230234072859 4388 2006902
SGTC_378 3970-0959 8.33 µM -1.28551241464092 0.153628194174845 no 2898 0.0993066406518086 4372 6615653
SGTC_259 usnic acid 108.925 µM -1.28602301615778 0.153529267855824 no 2899 0.0992175146035393 4409 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1935 st074532 41.6 µM -1.29100842414095 0.152565588875329 no 2900 0.0983503782011739 4325 2829742
SGTC_3079 9117512 49.47 µM -1.29312615813067 0.152157448191666 no 2901 0.0979837146868722 4430 7185044
SGTC_685 1278-0033 54.9 µM -1.29358186590986 0.152069716703226 no 2902 0.0979049447870935 4434 3590572
SGTC_1438 4092-1045 4 µM -1.29717101048744 0.151379919829428 no 2903 0.0972861764517922 4373 1351342
SGTC_1664 st014217 9.02 µM -1.29732925399777 0.151349555014121 no 2904 0.0972589614715489 4419 3982782
SGTC_1008 4106-0037 6 µM -1.29899505995815 0.151030154875911 no 2905 0.0969728122585055 4367 2905394
SGTC_477 mead ethanolamide 10 µM -1.30403017285321 0.150067455559894 no 2906 0.0961116474671135 4319 16061185
SGTC_2397 5161689 200 µM -1.30525840457032 0.14983324320332 no 2907 0.0959024363364722 4424 2259942
SGTC_1895 st058434 18.3 µM -1.30687894517208 0.14952459444594 no 2908 0.0956269139371255 4373 5393175
SGTC_2849 9019321 12.99 µM -1.30776289334633 0.149356416329648 no 2909 0.0954768718356194 4396 16489627
SGTC_604 1000-0114 314 µM -1.30823504445902 0.149266637614624 no 2910 0.0953967995409121 4390 1572745
SGTC_896 0964-0007 44.5 µM -1.30970427174904 0.148987497161758 no 2911 0.0951479489607789 4346 6756758
SGTC_961 1252-1571 372 µM -1.31039979312325 0.14885547582853 no 2912 0.0950303117903697 4383 6813498
SGTC_1448 4255-0083 152 µM -1.31198775301758 0.148554348139782 no 2913 0.0947621334058085 4405 5399660
SGTC_398 bronopol 33.3 µM -1.31448601797613 0.148081422662765 no 2914 0.0943413501581848 4296 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2191 5911152 200 µM -1.31507057790748 0.14797091017094 no 2915 0.0942430918507874 4396 2875902
SGTC_2820 7989630 71.43 µM -1.31534439875056 0.147919162658903 no 2916 0.0941970914487891 4400 2984098
SGTC_2638 epoxomicin 18 µM -1.31793164362098 0.147430815152188 no 2917 0.0937632658254249 4350 9915668 A protesome inhibitor.
SGTC_2556 citropten 84.59 µM -1.32134406092176 0.146788368584641 no 2918 0.0931933344264212 4404 2775 A potential DNA crosslinker.
SGTC_558 k064-0027 21.3 µM -1.32444304474815 0.146206560943901 no 2919 0.0926779734245195 4390 5088526
SGTC_173 1273-0061 2.693 µM -1.3258359714711 0.145945556100757 no 2920 0.0924470175810212 4347 2847414 YPL266W DIM1
SGTC_2322 7413319 38.22 µM -1.32722464312418 0.145685660406213 no 2921 0.0922171914378842 4355 1840400
SGTC_17 0960-0276 49.807 µM -1.33039917906959 0.145092702018279 no 2922 0.0916933924590626 4376 6821114
SGTC_2467 5474540 200 µM -1.33312951157815 0.144584015588304 no 2923 0.0912446530896832 4369 5413519
SGTC_1765 st044815 90.4 µM -1.33360779952299 0.144495029899208 no 2924 0.0911662127419373 4419 645695
SGTC_2898 9056270 58.44 µM -1.33687579535451 0.143888005372527 no 2925 0.0906315914307097 4390 19154699
SGTC_1106 tegaserod maleate 11.7 µM -1.33735328976111 0.143799455866352 no 2926 0.0905536719285457 4416 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2622 2-methoxyxanthone 59.94 µM -1.3385976242973 0.143568871576322 no 2927 0.0903508499760495 4368 71034 A hepatoprotective.
SGTC_1860 st056228 74.6 µM -1.33882508060736 0.143526749252965 no 2928 0.0903138119319919 4365 688679
SGTC_3061 glucosamine 200 µM -1.33884229663752 0.143523561379502 no 2929 0.0903110090040069 4323 91431 and experimental redox chemotherapeutic
SGTC_3042 9091578 49.47 µM -1.33924920059772 0.143448229333371 no 2930 0.0902447801054751 4401 25236497
SGTC_27 0485-0001 32.618 µM -1.34014328575318 0.143282796923049 no 2931 0.0900993828769165 4391 2054479
SGTC_1733 st037357 54.9 µM -1.34123595078892 0.143080796328309 no 2932 0.0899219287459883 4304 1272339 YGL099W LSG1
SGTC_1043 0916-0009 19.3 µM -1.34176757712808 0.142982584367423 no 2933 0.0898356840241963 4410 3101130
SGTC_1447 4239-0816 81.9 µM -1.34220138278577 0.142902477431456 no 2934 0.089765354130324 4402 1341554
SGTC_941 3237-0776 460 µM -1.34248217733695 0.142850641835133 no 2935 0.089719852688698 4425 760008
SGTC_738 1315-0003 72.4 µM -1.34306133055245 0.142743768391525 no 2936 0.0896260577824748 4418 6251474
SGTC_2378 9074213 121.43 µM -1.34383405750285 0.142601258209909 no 2937 0.089501026822544 4356 657714
SGTC_490 phenamil 164 µM -1.34583165968689 0.142233296351266 no 2938 0.0891784063177392 4403 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_732 3970-1727 52.7 µM -1.34597553461773 0.14220681916035 no 2939 0.0891552034099296 4483 1275699
SGTC_2364 9055074 200 µM -1.34653139923844 0.14210455516725 no 2940 0.0890656005663997 4402 6470630
SGTC_167 3672-0051 66.205 µM -1.34837110092246 0.141766455065301 no 2941 0.0887695270305616 4306 3237971
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.34884838462522 0.141678829016744 no 2942 0.0886928349512817 4427 94937 An inhibitor of serotonin biosynthesis.
SGTC_1113 artemisinin 1.17947 µM -1.35548388757235 0.140464396205205 no 2943 0.0876317193341022 4443 2240 An anti-malaria and mitochondrial poison.
SGTC_1620 st003704 16.5 µM -1.36034765377892 0.1395787290024 no 2944 0.0868599675038634 4393 2834414
SGTC_2273 7815444 169.05 µM -1.36096340215758 0.139466875761596 no 2945 0.0867626276842521 4350 2824616
SGTC_770 0389-1121 67.2 µM -1.36343046583305 0.139019335051751 no 2946 0.0863734424669331 4465 6753108
SGTC_3118 9124250 49.47 µM -1.36432843733534 0.138856680386354 no 2947 0.0862321098285259 4369 1504786
SGTC_1209 2323-2347 50.3 µM -1.36447663241668 0.138829849435266 no 2948 0.0862088018937266 4407 5412760
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.36702415503902 0.138369168470584 no 2949 0.0858088671964132 4311 4330530
SGTC_522 1273-0010 11.6 µM -1.36747961550418 0.138286915249391 no 2950 0.0857375111892014 4449 5705015
SGTC_2379 9035213 200 µM -1.36816544174232 0.138163122350156 no 2951 0.0856301480892214 4414 646551
SGTC_2175 5807670 165.306 µM -1.36868811426174 0.138068829748581 no 2952 0.0855483936048145 4364 241186
SGTC_1109 tnp00067 928.257 nM -1.36878019236189 0.138052222970337 no 2953 0.0855339971496453 4422 676295
SGTC_2765 myclobutanil 7.74 µM -1.36905259241017 0.138003102139826 no 2954 0.0854914178940708 4425 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3040 9091894 49.47 µM -1.37015943586905 0.137803632044291 no 2955 0.0853185688377194 4274 25236966
SGTC_1133 3473-0247 50 µM -1.37019949770074 0.137796415981201 no 2956 0.0853123175365189 4382 711311
SGTC_2282 7944268 200 µM -1.37130280179055 0.137597786700422 no 2957 0.0851402913299878 4412 2970414
SGTC_562 3772-2733 112 µM -1.3734257935861 0.137216131758162 no 2958 0.0848100078397367 4404 2876874 YIL048W NEO1
SGTC_2718 lomofungin 53.02 µM -1.37726614402881 0.136527581943576 no 2959 0.0842149892488391 4399 5351222 A RNA synthesis inhibitor.
SGTC_3302 9125395 16.351 µM -1.37877836782957 0.136257099632014 no 2960 0.0839815491645866 4368 17599668
SGTC_1139 k015-0024 46.9 µM -1.37912432656533 0.13619527166258 no 2961 0.0839282123088497 4446 2766652
SGTC_2846 9008642 19.48 µM -1.37942295374347 0.136141917987397 no 2962 0.0838821930728736 4451 2992898
SGTC_1698 5-fluorocytosine 1.055 µM -1.37984621147474 0.136066321932556 no 2963 0.0838170004073882 4438 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1050 3232-1156 69.3 µM -1.38231485005082 0.135625982666383 no 2964 0.0834375241337338 4385 700529
SGTC_97 0535-0701 19.132 µM -1.38348720292708 0.135417208454127 no 2965 0.0832577642630864 4322 2832013 YGL099W LSG1
SGTC_311 1315-0136 58 µM -1.38723971041138 0.134750438026076 no 2966 0.0826843401470206 4446 6759207
SGTC_2109 5483026 200 µM -1.38848850715619 0.134529043971144 no 2967 0.0824941710050019 4432 759335
SGTC_1921 5740136 50 µM -1.38883090697269 0.134468384953613 no 2968 0.082442087271214 4375 1774243
SGTC_2381 9035592 200 µM -1.39050336839688 0.134172364176753 no 2969 0.08218803858529 4434 4749657
SGTC_1323 1348-1351 11.2 µM -1.39057162903667 0.13416029175857 no 2970 0.0821776822595503 4409 6989654
SGTC_1114 scopoletin 1.73284 µM -1.39107254415154 0.134071723903502 no 2971 0.0821017147993287 4454 5280460 A coumarin with genotoxic properties.
SGTC_1411 3909-8223 150 µM -1.3914453314804 0.134005836669467 no 2972 0.0820452132053753 4439 X1411
SGTC_100 0086-0128 49.5915 µM -1.39278835593302 0.133768652117896 no 2973 0.0818419002817522 4436 93297
SGTC_2050 5263056 171 µM -1.39279544064096 0.133767401690203 no 2974 0.0818408287753822 4416 763468 YGL055W OLE1
SGTC_3221 9128209 49.47 µM -1.39501687604851 0.133375721830744 no 2975 0.0815053752855287 4456 16460723
SGTC_1012 4112-3522 18 µM -1.39879606367766 0.132711195935322 no 2976 0.0809370735269477 4436 3112398
SGTC_3354 9151612 71.43 µM -1.39941435100318 0.132602694788205 no 2977 0.0808443829265946 4434 27261949
SGTC_1490 4089-0339 670 nM -1.4007160773853 0.132374459050623 no 2978 0.0806494965155656 4405 742542
SGTC_168 3970-0862 530.542 µM -1.40254649832833 0.132053983893824 no 2979 0.0803760577483854 4370 3135186
SGTC_727 3032-0951 202 µM -1.40299201108921 0.131976063315556 no 2980 0.0803096106196872 4479 3652836
SGTC_2000 st075254 36.4 µM -1.40500011708653 0.131625237422782 no 2981 0.0800106217274722 4325 17234175
SGTC_724 3910-0327 137 µM -1.40681935671704 0.131307963528007 no 2982 0.0797404806275904 4473 2885483
SGTC_2936 9038235 15.59 µM -1.40733989167652 0.131217279909892 no 2983 0.0796633128489775 4364 4749415
SGTC_2544 sphondin 68.51 µM -1.40874466312403 0.13097276728592 no 2984 0.079455341584659 4401 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_3242 9133940 49.47 µM -1.4155551139187 0.129791813388082 no 2985 0.0784529005619616 4444 17248444
SGTC_2636 apigenin dimethyl ether 100 µM -1.41609604872315 0.129698330668224 no 2986 0.0783736924115369 4412 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_530 4358-1714 28 µM -1.42032408620104 0.128969260635221 no 2987 0.0777566760548948 4431 1564641
SGTC_2130 NSC 7 2.4545 µM -1.42481372850269 0.12819819697815 no 2988 0.0771055264064629 4504 21448
SGTC_298 1391-0729 10 µM -1.42673408597208 0.127869368959538 no 2989 0.0768282783439747 4391 3237558
SGTC_1291 0993-0025 5.79 µM -1.42723028024732 0.127784499637685 no 2990 0.0767567645798834 4438 4353356
SGTC_2655 perillic acid 100 µM -1.42834372096687 0.127594198680946 no 2991 0.0765964747027309 4509 5702197 An apoptosis inducer.
SGTC_3183 9108214 49.47 µM -1.43452661293483 0.126541050237628 no 2992 0.0757110200756058 4437 4974831
SGTC_3091 9116372 49.47 µM -1.43563361622177 0.126353132371347 no 2993 0.0755533119599615 4505 17169793
SGTC_1751 st044839 27.194 µM -1.43591188842578 0.126305925244507 no 2994 0.0755137075863132 4502 5291326
SGTC_895 0964-0006 13.7 µM -1.43665811830862 0.126179392722805 no 2995 0.0754075804374681 4452 6738897
SGTC_3027 9089541 49.47 µM -1.43871213957861 0.125831564373496 no 2996 0.0751160492075731 4443 9943819
SGTC_345 1362-0200 395 µM -1.43908754368977 0.125768065722082 no 2997 0.0750628603903624 4446 1419823
SGTC_50 0929-0078 56.389 µM -1.44182186679792 0.125306236211548 no 2998 0.0746763162315777 4310 1377751
SGTC_281 1672-3440 14.9 µM -1.44192347197536 0.125289097854818 no 2999 0.0746619818986643 4501 6833000
SGTC_3120 9124077 49.47 µM -1.44236237468976 0.125215084296043 no 3000 0.0746000861713904 4575 18774327 YGL155W CDC43
SGTC_1597 7-benzyloxygramine 47.5 µM -1.44372871111847 0.124984870120601 no 3001 0.0744076509415322 4367 260807
SGTC_2096 5468907 200 µM -1.44737714218703 0.124371594930144 no 3002 0.0738956620394475 4463 759785
SGTC_1707 st032323 6.317 µM -1.44864752992059 0.124158546603425 no 3003 0.0737180202484168 4287 3132057 YMR211W DML1
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.45076616529423 0.123803812472912 no 3004 0.0734224920762575 4493 6708784 An antioxidant flavonoid
SGTC_123 0083-0120 66.675 µM -1.45103305110178 0.123759176763063 no 3005 0.0733853285607753 4444 16001701
SGTC_2255 7941087 197.44 µM -1.45218218899106 0.123567116200857 no 3006 0.0732254768680119 4555 935561
SGTC_1500 4488-1866 171 µM -1.45309223730007 0.12341516393531 no 3007 0.073099073041598 4512 2900003
SGTC_87 0100-0052 35.5 µM -1.45345625173095 0.123354420512346 no 3008 0.0730485589686252 4486 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_787 4152-0075 138 µM -1.46181422657603 0.121965476401819 no 3009 0.0718960622490592 4498 9566539
SGTC_832 4083-0019 164 µM -1.46371535522743 0.121651082667179 no 3010 0.0716358690996605 4551 1990758
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -1.46382510647702 0.121632950271365 no 3011 0.0716208703587133 4483 2374 Ca(2+)-ATPase inhibitor.
SGTC_655 k060-0012 42 µM -1.46516014418361 0.121412535993586 no 3012 0.0714386153155741 4469 5994525
SGTC_992 3909-8734 162 µM -1.46572179073376 0.121319892306717 no 3013 0.0713620475935033 4485 4288319
SGTC_3349 9149703 23.001 µM -1.46892475323745 0.120792513195726 no 3014 0.0709265999313444 4495 4910494
SGTC_2747 doxorubicin 7.63 µM -1.46932896643612 0.120726072904157 no 3015 0.0708717918820677 4522 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2278 7948257 134.34 µM -1.47029581238209 0.120567257358144 no 3016 0.0707408273612027 4482 1247028
SGTC_224 benfluorex 43.875 µM -1.47268662899232 0.120175170102509 no 3017 0.0704177768144301 4480 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2773 thioridazine 9.09 µM -1.47354712806208 0.120034270774824 no 3018 0.070301782941679 4460 5452 An antipsychotic.
SGTC_192 3455-0609 60.9 µM -1.47459094356071 0.119863511289224 no 3019 0.0701612755936924 4536 3769639
SGTC_2720 fluspirilene 36.88 µM -1.47711859747391 0.119450717956355 no 3020 0.0698219245926347 4468 3396 An atypical antipsychotic.
SGTC_1579 chlormadinone acetate 49.4 µM -1.4775539819667 0.11937971632478 no 3021 0.0697635996548143 4507 45114258 A steroidal progestin.
SGTC_1011 4112-3381 17.4 µM -1.47815872051466 0.119281146189538 no 3022 0.0696826499527289 4523 2877139
SGTC_654 1124-0271 80.9 µM -1.47894802421424 0.119152579051704 no 3023 0.069577103346139 4472 5403748
SGTC_1005 4092-0690 4.4 µM -1.48176892498419 0.118693891266349 no 3024 0.0692008951173481 4499 1529343
SGTC_190 3970-0790 3.722 µM -1.48467387639799 0.118222841853931 no 3025 0.0688151175430083 4452 2832352
SGTC_3020 9089140 49.47 µM -1.48637047717046 0.117948343528173 no 3026 0.0685905771701995 4508 17217859
SGTC_2921 7974240 10.71 µM -1.48823127224913 0.117647798495016 no 3027 0.0683449563826073 4551 2979074 YDR527W RBA50
SGTC_2117 5521686 200 µM -1.49210981201829 0.117023102221334 no 3028 0.0678351800208588 4474 803312
SGTC_780 0109-0199 192 µM -1.49517357093427 0.116531302892613 no 3029 0.0674345745651551 4520 610414
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.49543902723106 0.116488760546524 no 3030 0.0673999507679443 4410 17037758
SGTC_910 3454-3003 490 µM -1.49583993793779 0.116424530997309 no 3031 0.0673476855307026 4407 820824
SGTC_1590 st077108 57.8 µM -1.49635591020077 0.116341904515849 no 3032 0.0672804662587482 4504 5489485
SGTC_2737 bleomycin 30.5 nM -1.49664152488051 0.11629618480282 no 3033 0.0672432795690293 4583 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2288 7946289 167.31 µM -1.49681472972217 0.116268465282528 no 3034 0.0672207362471531 4508 1246052
SGTC_2951 9072950 58.06 µM -1.49860438825737 0.115982324673785 no 3035 0.0669881468187579 4417 16488155
SGTC_1784 st039334 36.3 µM -1.49931610135428 0.115868671060264 no 3036 0.0668958236189815 4487 3496984
SGTC_3164 9100705 49.47 µM -1.50143125981795 0.115531367786056 no 3037 0.0666220268473763 4516 17174235
SGTC_2571 chrysanthemic acid 100 µM -1.5059896972497 0.114806809379572 no 3038 0.0660349092521282 4479 2743 An insecticide.
SGTC_2062 5245942 200 µM -1.51573400314917 0.113268818404722 no 3039 0.0647933129645188 4533 1376160
SGTC_1729 st035615 45.989 µM -1.5210562718726 0.112435012128427 no 3040 0.0641228583214117 4505 17385451
SGTC_3138 9097216 49.47 µM -1.52287949461049 0.112150390205864 no 3041 0.0638944283986402 4436 25237486
SGTC_1315 1237-0019 3.69 µM -1.52840292763906 0.111291275686374 no 3042 0.0632062641979403 4510 825140
SGTC_773 4358-1457 44.6 µM -1.53033626176587 0.110991680989172 no 3043 0.0629667584742625 4493 1186886
SGTC_1004 4084-0029 199 µM -1.53392040225563 0.110437801871805 no 3044 0.0625246180437949 4518 716894 YLR208W SEC13
SGTC_3293 9120939 62.045 µM -1.54175174789758 0.10923447816341 no 3045 0.0615669658196088 4501 934087
SGTC_212 3807-4682 38.772 µM -1.54304144296474 0.10903721723581 no 3046 0.0614103604579436 4586 3125501 YBL034C STU1
SGTC_2335 9018011 154.17 µM -1.54675695491403 0.108470355347976 no 3047 0.0609609317444513 4489 6458208
SGTC_1183 1254-0324 198 µM -1.54845050408298 0.108212681474864 no 3048 0.0607569348669232 4558 5799357
SGTC_514 4466-0038 2.65 nM -1.55093864378439 0.10783491009411 no 3049 0.0604581942202774 4302 5722064
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.55464749624725 0.107273564012312 no 3050 0.0600150226818546 4558 5282309
SGTC_976 1348-1067 47.6 µM -1.55515052855955 0.107197591092597 no 3051 0.0599551116643666 4547 5310671 YGL099W LSG1
SGTC_2981 9013952 38.96 µM -1.55766168254408 0.106818911996365 no 3052 0.0596567341417645 4468 2996344
SGTC_1019 4262-0212 3.4 µM -1.55828203926186 0.106725511783065 no 3053 0.0595832023396966 4526 4677213
SGTC_565 1418-0001 44.5 µM -1.56281609908277 0.10604465793744 no 3054 0.0590479282020788 4566 2862145
SGTC_2894 9048625 32.47 µM -1.56872066592309 0.105162715079855 no 3055 0.0583565205237484 4522 4092861
SGTC_2515 chrysin 20.77 µM -1.5700099703737 0.104970844627031 no 3056 0.0582063958685572 4521 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1437 4092-1038 11.6 µM -1.57056664729449 0.104888079999491 no 3057 0.0581416711073394 4588 3977136
SGTC_858 0438-0351 2.77 µM -1.57193500792534 0.104684838120387 no 3058 0.0579828123192722 4517 2799119
SGTC_1343 1487-0095 224 µM -1.57255894013392 0.104592260539449 no 3059 0.057910490712067 4523 4560101 YGL055W OLE1
SGTC_913 3487-1245 167 µM -1.57323972844647 0.104491314458966 no 3060 0.0578316596784275 4469 4016153
SGTC_38 0929-0051 58.268 µM -1.57528208518542 0.104188900992245 no 3061 0.0575956736252483 4484 1379719
SGTC_3107 9121808 49.47 µM -1.5783118702802 0.10374144768335 no 3062 0.0572469901193185 4484 662681
SGTC_567 1080-0542 68.4 µM -1.57834124404902 0.103737116457217 no 3063 0.0572436177816794 4426 5950415
SGTC_1983 st071813 46.9 µM -1.58853441167754 0.102242022994384 no 3064 0.0560827730347706 4604 11838595
SGTC_1158 4092-0494 91.8 µM -1.59309060555621 0.101578830916714 no 3065 0.0555699332683496 4609 1148199
SGTC_2646 retinol 96.75 µM -1.5990192110003 0.100720570495043 no 3066 0.0549081670212321 4561 445354 A vitamin A analog and teratogen.
SGTC_1174 0739-0097 51.1 µM -1.60405036016414 0.0999963896688856 no 3067 0.0543514762142899 4566 728447
SGTC_2802 7925815 54.55 µM -1.60639084823248 0.0996607999388883 no 3068 0.054094030212733 4522 1262923
SGTC_16 erodoxin 22.806 µM -1.60818206309207 0.099404523911132 no 3069 0.0538976551994288 4588 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_518 1021-0119 62.6 µM -1.60848933210067 0.0993606101975655 no 3070 0.0538640253775796 4530 1097762
SGTC_152 4469-0003 551.229 µM -1.60859516266026 0.0993454885820583 no 3071 0.0538524463359552 4525 697280
SGTC_3124 9127567 49.47 µM -1.60929239566572 0.0992459063919537 no 3072 0.0537762105404807 4502 17592030
SGTC_285 1486-1325 46 µM -1.61326941522195 0.0986792844798318 no 3073 0.0533429941270757 4587 22310230
SGTC_1799 st045822 46.1415 µM -1.61745188178974 0.0980859499560182 no 3074 0.0528903871869705 4537 3674992
SGTC_3234 9132280 49.47 µM -1.62046618069035 0.0976599580739908 no 3075 0.0525660867200533 4569 17612295
SGTC_2810 7959871 45.46 µM -1.62125897219953 0.0975481434870134 no 3076 0.052481055027838 4505 2974535
SGTC_187 1488-2104 32.728 µM -1.6225142565854 0.0973712913938402 no 3077 0.0523466415227861 4554 2852859
SGTC_1903 st060211 78.3 µM -1.62658393768292 0.0967995475305914 no 3078 0.0519127464945496 4576 688960
SGTC_2610 ononetin 44.17 µM -1.62738607402569 0.0966871479366118 no 3079 0.0518275636547126 4533 259632
SGTC_1085 doxorubicin 7.67 µM -1.628904663923 0.0964746176529621 no 3080 0.0516666013125055 4567 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2708 st078559 56 µM -1.62920894779176 0.0964320737095108 no 3081 0.0516343967067135 4522 17250902
SGTC_1552 6-methylflavone 10.6 µM -1.63447611959487 0.0956978188866464 no 3082 0.051079458260764 4510 689013
SGTC_2181 6316240 54.2555 µM -1.63682198622502 0.0953721273449329 no 3083 0.0508338351928706 4586 12779990
SGTC_840 0245-0196 390 µM -1.63847397446111 0.0951432614747505 no 3084 0.0506614293864965 4627 3827528
SGTC_2473 5854593 8.94 µM -1.63854204021926 0.095133840351901 no 3085 0.0506543358679134 4522 2872951
SGTC_1015 4130-4525 82 µM -1.63857089341356 0.0951298469287464 no 3086 0.0506513291516903 4569 1363237
SGTC_2492 derrusnin 100 µM -1.64895447758756 0.0937007124072557 no 3087 0.0495784805625568 4592 1715307 Part of coumarin class of compounds.
SGTC_1923 st058458 19.1 µM -1.65145955931949 0.0933583135624463 no 3088 0.0493223859501301 4543 3534982
SGTC_2271 7849410 118.62 µM -1.65866517824261 0.0923785915127446 no 3089 0.0485916399621187 4509 972430
SGTC_42 0133-0086 60.653 µM -1.65947397351441 0.0922690992344565 no 3090 0.0485101604659777 4468 162923 Model of phenazepam hydroxylation.
SGTC_1940 st075990 51.1 µM -1.66187871841927 0.0919441194740693 no 3091 0.0482685472816241 4601 1084979
SGTC_2725 haloperidol 53.21 µM -1.662481868251 0.0918627422951315 no 3092 0.0482080979528751 4546 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2837 9008476 45.46 µM -1.66356526246095 0.0917167043737543 no 3093 0.0480996693365332 4532 2992805
SGTC_1207 2099-0101 141 µM -1.66601019392121 0.0913877679635135 no 3094 0.0478556920368301 4573 5837381
SGTC_692 k241-0027 77.8 µM -1.67046106153704 0.0907912031447579 no 3095 0.0474140886299766 4599 3600480
SGTC_1283 0922-0125 16.4 µM -1.67317241082284 0.0904292109915569 no 3096 0.0471466799570738 4580 3360884
SGTC_1373 2887-0003 58.5 µM -1.67418737006932 0.0902939798441155 no 3097 0.0470468904442683 4541 776948
SGTC_2402 5553605 200 µM -1.67539331222358 0.0901334978298483 no 3098 0.046928543958266 4611 6758546
SGTC_84 0443-0269 128.823 µM -1.6788314510424 0.089677127245872 no 3099 0.0465924485905398 4538 6150058
SGTC_2441 5730946 39.09 µM -1.68028087994113 0.0894852490456223 no 3100 0.0464513396719344 4612 1774275
SGTC_1769 st044406 64.4 µM -1.68278491180138 0.0891544801567118 no 3101 0.0462083684616345 4557 670903
SGTC_2752 diclazuril 33.15 µM -1.6840141217557 0.0889924415845807 no 3102 0.0460894698003893 4494 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1 0258-0098 57.368 µM -1.68571321938471 0.0887688219280601 no 3103 0.0459255247232193 4509 6790032 YDR047W HEM12
SGTC_150 3970-0969 77.2 µM -1.68827505009284 0.0884324487163413 no 3104 0.0456792211608593 4591 6615640
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.69010077386517 0.0881933079605856 no 3105 0.0455043384372988 4569 442882
SGTC_265 mycophenolic acid 32.932 µM -1.69079814139902 0.0881020912532489 no 3106 0.0454376811484934 4635 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1830 st055982 50.3 µM -1.6910487549884 0.088069327810173 no 3107 0.0454137456491239 4576 455313 An antimicrobial agent.
SGTC_2277 7947813 106.88 µM -1.69791643146361 0.0871750282176506 no 3108 0.0447617677726002 4597 1246798
SGTC_2490 carminic acid 95.39 µM -1.70216151808842 0.0866256402916145 no 3109 0.0443625471779138 4587 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3007 9078383 71.4286 µM -1.70244305902238 0.0865892957213449 no 3110 0.0443361720146211 4594 6496995
SGTC_1654 st012436 41.8 µM -1.70402152824197 0.0863857396699532 no 3111 0.0441885326832849 4592 4323132
SGTC_2329 6138490 200 µM -1.70653390393358 0.0860624873366551 no 3112 0.0439543597205581 4590 720019
SGTC_451 chloral hydrate 100 µM -1.71240754189176 0.0853102938694816 no 3113 0.0434107950823532 4575 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2469 5655019 90.81 µM -1.71812634680986 0.0845826713249469 no 3114 0.0428867860611081 4648 2788239
SGTC_753 1322-0200 289 µM -1.72095651674333 0.0842243058944927 no 3115 0.0426293573612325 4638 5403907
SGTC_904 1141-0088 396 µM -1.72161862576491 0.0841406322000514 no 3116 0.0425693134421768 4617 1378119
SGTC_1851 st056236 18.9 µM -1.72195882580642 0.0840976638666766 no 3117 0.0425384887189509 4572 5393171
SGTC_1033 k072-0102 21.3 µM -1.72287580234414 0.0839819288939669 no 3118 0.0424554935235148 4550 5965931
SGTC_3215 9129942 49.47 µM -1.72670738499511 0.0834996244907676 no 3119 0.0421101143470634 4566 17682944
SGTC_2136 5328288 199.296 µM -1.72769648738512 0.0833754588973691 no 3120 0.0420213268236044 4561 262395
SGTC_1693 xanthone 101.9 µM -1.73093792880346 0.0829695216974675 no 3121 0.0417314179260725 4647 7020 An insecticide.
SGTC_216 k038-0035 28.382 µM -1.73113839052063 0.0829444660651782 no 3122 0.0417135422983248 4555 4444231 YPR107C YTH1
SGTC_2164 5685496 200 µM -1.73362639954954 0.0826339643284224 no 3123 0.0414921966090106 4549 759046
SGTC_2196 6573537 42.6665 µM -1.73447502787735 0.082528256457145 no 3124 0.041416916427819 4629 2903087
SGTC_1750 st081859 2.357 µM -1.74393673349512 0.0813565618073269 no 3125 0.0405850612041552 4516 5291695
SGTC_1350 1495-0454 146 µM -1.74635122330032 0.0810595816483234 no 3126 0.0403749700520936 4630 1069057
SGTC_726 3448-4391 34.2 µM -1.74786461967587 0.0808738527743614 no 3127 0.0402437362767566 4665 1356692
SGTC_631 k072-0230 41.5 µM -1.74865643497454 0.0807768067594754 no 3128 0.0401752124006607 4609 5773147
SGTC_547 1120-0019 610 nM -1.76822481340598 0.0784063259066553 no 3129 0.0385116637712597 4586 3676939
SGTC_1041 0206-0046 107 µM -1.76939112456354 0.0782667242985198 no 3130 0.0384143128726822 4622 50494
SGTC_1553 gossypol 38.6 µM -1.76969219472935 0.0782307183350989 no 3131 0.0383892154294223 4587 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_808 0711-0032 135 µM -1.77064904004041 0.0781163694899388 no 3132 0.0383095407943716 4589 4252555
SGTC_227 fluconazole 33.516 µM -1.77510854237018 0.0775851037320872 no 3133 0.0379399833874869 4615 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1647 st011722 22.4 µM -1.7752302246768 0.0775706461205181 no 3134 0.0379299405278087 4618 2854783
SGTC_1876 myriocin 605 nM -1.77717432203828 0.0773399366747475 no 3135 0.0377697814408022 4601 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_839 0122-0028 230 µM -1.7813120197318 0.0768506444964217 no 3136 0.0374307459886284 4636 759448
SGTC_2373 9071805 200 µM -1.79192152955429 0.0756068017094062 no 3137 0.0365727683571738 4621 10149009
SGTC_1567 st069303 68.4 µM -1.79218670788533 0.07557591025577 no 3138 0.0365515315675342 4616 5581319
SGTC_33 0986-0033 35.816 µM -1.79381689753816 0.0753862156054456 no 3139 0.0364211994923119 4618 2848082
SGTC_1340 1486-1359 257 µM -1.79478834563556 0.075273347149266 no 3140 0.0363437141763209 4598 4309068
SGTC_861 0443-0273 110 µM -1.79836902259644 0.0748584357385182 no 3141 0.0360592741778908 4624 6149169
SGTC_3119 9125183 49.47 µM -1.80858581573237 0.0736841545513706 no 3142 0.035257686872003 4564 22695334
SGTC_538 2922-0838 53.3 µM -1.81102924026325 0.0734054138989654 no 3143 0.0350681627670781 4649 777039
SGTC_2391 6285546 200 µM -1.822188207656 0.0721426650839618 no 3144 0.0342132166238498 4636 846083
SGTC_2628 lathosterol 100 µM -1.82877613141056 0.0714050314150099 no 3145 0.0337165760232956 4655 6710616
SGTC_812 4251-0442 148 µM -1.8349615870574 0.0707177430597537 no 3146 0.033255690626428 4654 5723007
SGTC_1793 st048256 72.231 µM -1.83780566629918 0.0704034382058144 no 3147 0.0330455231945932 4639 672022
SGTC_3144 9087057 49.47 µM -1.84176058514859 0.069968158862886 no 3148 0.0327550888891431 4571 17249618
SGTC_2493 resveratrol 26.09 µM -1.84208189639829 0.0699328864187814 no 3149 0.0327315857303921 4618 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1953 st076800 12.1 µM -1.84231618680729 0.0699071754504804 no 3150 0.0327144567082222 4603 297591
SGTC_1919 st067113 52.3 µM -1.84271874965636 0.069863015296134 no 3151 0.0326850425125434 4598 1268243
SGTC_478 N-arachidonylglycine 10 µM -1.84412801361116 0.0697085916184685 no 3152 0.0325822431026699 4681 5283389
SGTC_1088 bifonazole 369 nM -1.84564617309021 0.0695425295756638 no 3153 0.0324717987812831 4641 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_65 0798-0905 34.986 µM -1.85580587446305 0.0684390526234767 no 3154 0.0317406164778875 4604 3602145
SGTC_3316 9136639 10.545 µM -1.857615934307 0.0682438819288787 no 3155 0.0316117870459585 4648 4903665
SGTC_2489 cantharidin 73.42 µM -1.8665512551696 0.0672867141877186 no 3156 0.0309821400392054 4602 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_279 1273-0055 2.93 µM -1.86735957452526 0.0672006400352774 no 3157 0.0309256955594099 4692 2847562
SGTC_649 1123-0311 367 µM -1.87212401428286 0.0666950258204023 no 3158 0.0305947241903456 4551 693629 YIL048W NEO1
SGTC_1306 1185-0270 9.02 µM -1.8721467416593 0.0666926210094868 no 3159 0.0305931524457048 4662 1548076
SGTC_3226 9131256 49.47 µM -1.87743795578541 0.0661345754853086 no 3160 0.0302290467359091 4672 17178073
SGTC_2496 diffractaic acid 79.83 µM -1.88188296646023 0.0656685775183729 no 3161 0.0299259538304697 4634 94870 An apoptosis inducer which activates caspases.
SGTC_1973 st070275 50.2 µM -1.88207265130323 0.065648748462091 no 3162 0.0299130760264864 4648 17118334
SGTC_1418 3966-3099 2.4 µM -1.88328101984893 0.0655225383804818 no 3163 0.0298311471093226 4662 740335
SGTC_1503 4585-0012 61.3 µM -1.88422805852076 0.0654237549231936 no 3164 0.0297670668782613 4678 2922052
SGTC_1812 st052057 4.327 µM -1.89111438944137 0.0647089274553166 no 3165 0.029304538040726 4680 3645418
SGTC_1433 4060-0023 7.6 µM -1.89134835744449 0.0646847476484066 no 3166 0.0292889287267486 4681 3840627
SGTC_1606 st000094 49.2 µM -1.89637343692363 0.0641671146038689 no 3167 0.0289553408967556 4679 1242210
SGTC_1252 0493-0875 34.8 µM -1.89785295449493 0.064015324809501 no 3168 0.0288577275910127 4622 3960963
SGTC_369 0957-0393 4.5 µM -1.89894965361995 0.0639029902218302 no 3169 0.0287855479523165 4640 6997992
SGTC_2123 5259487 200 µM -1.90230647655606 0.0635601043966957 no 3170 0.0285655497393707 4653 2173474
SGTC_2177 5811945 192 µM -1.91050892839381 0.0627282808870929 no 3171 0.0280338589587148 4640 5343475
SGTC_128 0906-2981 13.371 µM -1.9167105900643 0.0621050117930019 no 3172 0.0276373545644165 4649 6740226
SGTC_3244 9134489 49.47 µM -1.91801716709401 0.0619743186250098 no 3173 0.027554417208256 4659 16584271
SGTC_537 1334-0398 209 µM -1.92379300413405 0.0613991479589082 no 3174 0.0271902673437203 4681 5846986
SGTC_1992 st073643 23.3 µM -1.93402892372025 0.060390085075248 no 3175 0.0265547858737458 4665 3161292
SGTC_2566 crystal violet carbinol 226 nM -1.93406323936631 0.0603867241791235 no 3176 0.0265526764901974 4596 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1841 st054148 70 µM -1.94015293132344 0.0597926102890332 no 3177 0.0261805534211853 4688 675442
SGTC_1999 st074831 12.5 µM -1.94233452684958 0.0595808900889011 no 3178 0.0260483079020039 4651 17112523
SGTC_201 4262-0159 12.803 µM -1.94235100006849 0.0595792936283997 no 3179 0.0260473114459814 4710 1341029
SGTC_1802 st050112 57.9 µM -1.94273473508977 0.0595421144010765 no 3180 0.0260241085440697 4687 4662563
SGTC_1157 4092-0394 27.6 µM -1.94859339797919 0.0589767369631323 no 3181 0.0256720005952285 4699 3659885
SGTC_1813 st051246 8.6015 µM -1.95507878312963 0.0583558001133194 no 3182 0.0252868860483093 4648 5291959
SGTC_997 3996-0078 137 µM -1.96125692155764 0.0577690670614285 no 3183 0.0249245298919587 4703 735687
SGTC_3339 9145883 14.936 µM -1.96280600257119 0.0576226817484043 no 3184 0.0248343600376075 4615 2030670
SGTC_3277 9138724 49.47 µM -1.97894206837927 0.0561151434903888 no 3185 0.0239112645487102 4678 15943418
SGTC_465 cgp-37157 41 µM -1.98566023172012 0.0554967322892592 no 3186 0.0235355317928526 4738 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2106 5357045 167.29 µM -1.98681610960986 0.0553908775396538 no 3187 0.0234713893674735 4692 668842
SGTC_2561 acetosyringone 100 µM -1.98712378049356 0.0553627280690987 no 3188 0.0234543407800811 4640 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2360 9040895 200 µM -1.99271634725211 0.0548530184559108 no 3189 0.0231462581507256 4694 4914414
SGTC_1492 4158-0558 28.5 µM -1.99782075478055 0.0543910442189309 no 3190 0.0228680481923611 4683 3967268
SGTC_1108 betulinic acid 729.144 nM -2.00082885207587 0.0541202411561605 no 3191 0.022705418499702 4659 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3170 9103054 49.47 µM -2.00102468185413 0.0541026487001908 no 3192 0.0226948650445187 4656 16432970
SGTC_35 0133-0054 64.071 µM -2.00415847129434 0.0538217386208588 no 3193 0.0225265437833251 4635 99677
SGTC_2989 9073649 71.4286 µM -2.00616917120978 0.0536421103814828 no 3194 0.0224191009247946 4642 21367202
SGTC_559 1550-0661 158 µM -2.00659056314828 0.053604525095529 no 3195 0.0223966384804503 4703 5830875
SGTC_198 3454-2873 16.191 µM -2.00944507871715 0.0533504708074172 no 3196 0.0222449768170481 4694 710957
SGTC_978 1416-0512 87.4 µM -2.01037293264636 0.0532680968424324 no 3197 0.0221958665171441 4699 6814003
SGTC_921 1561-0023 372 µM -2.01456169686441 0.0528974766447902 no 3198 0.021975297117388 4668 24050882
SGTC_1160 4092-0570 10.5 µM -2.01884214515783 0.0525208602911508 no 3199 0.0217518145274334 4682 4994975
SGTC_1779 st039427 55 µM -2.0265226462442 0.0518504279781376 no 3200 0.0213556272202019 4673 1124498
SGTC_1495 4469-0029 237 µM -2.03182700277251 0.0513913933645686 no 3201 0.0210855862643651 4691 793680
SGTC_912 3474-0017 2.18 µM -2.03560237121249 0.0510666495589763 no 3202 0.020895149751712 4682 3360550
SGTC_118 0083-0097 135.343 µM -2.04220925426407 0.0505022806493213 no 3203 0.0205653894528264 4663 5207356
SGTC_2595 hexamethylquercetagetin 100 µM -2.047302824657 0.0500705822207683 no 3204 0.0203141803701305 4657 386331
SGTC_1687 st020778 55.3625 µM -2.04851257078978 0.0499684854920611 no 3205 0.020254900813524 4726 4259299
SGTC_3151 9099821 49.47 µM -2.0581533989134 0.0491607678623698 no 3206 0.0197877052023393 4642 17174189
SGTC_1383 3049-0032 20.7 µM -2.06344801750637 0.0487216356511105 no 3207 0.019535040909025 4711 712864
SGTC_891 0929-0073 133 µM -2.06620238030115 0.0484944335266704 no 3208 0.0194046871012653 4710 5603632
SGTC_761 k216-0224 480 µM -2.06887317963268 0.0482749342317616 no 3209 0.0192789944959292 4705 1340404
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -2.07592397191035 0.0476992830743728 no 3210 0.0189504916068745 4702 616764
SGTC_1483 3453-0561 55.9 µM -2.09025188110739 0.0465464425710836 no 3211 0.018297589646471 4731 4546991
SGTC_779 1360-0071 233 µM -2.10690233011703 0.0452349358370171 no 3212 0.017563023303032 4716 7566
SGTC_2336 9001819 198.65 µM -2.11164259335252 0.0448670458650132 no 3213 0.0173585581653431 4672 2989602
SGTC_1067 clotrimazole 1.36 µM -2.11187618290566 0.0448489795308793 no 3214 0.0173485353588378 4745 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_120 rhodamine 6G 52.259 µM -2.11833091341057 0.0443520692109 no 3215 0.0170735261620806 4699 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1330 1469-0054 61.8 µM -2.12841347398126 0.0435847618436945 no 3216 0.0166514084868416 4677 7102664
SGTC_1055 3448-0672 86 µM -2.13285949412143 0.0432498299097773 no 3217 0.0164681270105422 4687 748378
SGTC_3094 9117742 49.47 µM -2.14050012899131 0.042679095870789 no 3218 0.0161571851945643 4684 17149698
SGTC_2667 digitoxin 100 µM -2.14441472792395 0.0423890539163365 no 3219 0.0159998356070381 4719 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_156 3474-0145 5.642 µM -2.14948148050694 0.0420160157462036 no 3220 0.0157981262929711 4655 2265471
SGTC_1099 5-nonyloxytryptamine 2.85 µM -2.16055965465899 0.041209643513955 no 3221 0.0153646854007869 4738 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3334 9142812 21.919 µM -2.16151032076719 0.0411410337804296 no 3222 0.0153279702902579 4703 45283678
SGTC_2263 7948595 193.29 µM -2.16287845035848 0.041042458225036 no 3223 0.0152752648175234 4724 2971371
SGTC_1631 benzylvanillin 81.9 µM -2.16800010770102 0.0406751354821677 no 3224 0.0150793391718021 4717 75506
SGTC_2866 9034245 58.44 µM -2.17089696509396 0.0404685584230979 no 3225 0.0149694809043207 4734 6462273
SGTC_3050 9093513 49.47 µM -2.18353266006938 0.039577436821325 no 3226 0.0144983032534766 4687 25236664
SGTC_2662 daunorubicin 22.37 µM -2.18580656519252 0.0394187787175627 no 3227 0.0144148801265314 4632 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -2.18841452219878 0.0392374501333184 no 3228 0.0143197107027532 4692 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1371 2421-0008 32.7 µM -2.19322592799468 0.0389046997180471 no 3229 0.0141455526757596 4720 2827552
SGTC_1801 st050089 28.441 µM -2.19336762247577 0.0388949352594762 no 3230 0.0141404515599807 4735 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_784 4579-0127 173 µM -2.20549214912553 0.0380667726308615 no 3231 0.013709789053238 4731 1948547
SGTC_3169 9102970 49.47 µM -2.21416981815484 0.0374829230105267 no 3232 0.0134085496255132 4765 17027839
SGTC_2838 9002687 71.43 µM -2.21501510815729 0.0374264433326749 no 3233 0.0133795137700738 4700 6457060
SGTC_1954 st077032 68.9 µM -2.22613593555661 0.0366898362236237 no 3234 0.0130025387708348 4681 698907
SGTC_2932 9016711 44.54 µM -2.22678638098522 0.0366471225379081 no 3235 0.0129807770109695 4702 7117328
SGTC_2955 9076254 12.21 µM -2.23170408878628 0.0363254994564267 no 3236 0.0128172634195338 4700 16459619
SGTC_2519 cryptotanshinone 88.04 µM -2.23705888341134 0.0359779218357741 no 3237 0.0126412458962514 4729 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2221 6807166 181.081 µM -2.23978754242335 0.0358018561614522 no 3238 0.0125523595065536 4738 674925
SGTC_2399 5884133 200 µM -2.24195651249205 0.0356624083786883 no 3239 0.0124820915247278 4670 722445
SGTC_3201 9113999 49.47 µM -2.24989217910582 0.0351559964139677 no 3240 0.0122278952678209 4694 16649224
SGTC_464 bw-b 70c 158 µM -2.25183427824924 0.0350329647880828 no 3241 0.0121663733087886 4720 5353454
SGTC_1836 st055642 81 µM -2.25477856388612 0.0348471189193213 no 3242 0.0120736157193959 4713 8571
SGTC_699 0375-0592 111 µM -2.26358932580672 0.0342958058873995 no 3243 0.0117996924875076 4765 762578
SGTC_3097 9117246 49.47 µM -2.26814790963244 0.0340133891947436 no 3244 0.0116600965568684 4746 16423892
SGTC_1040 k898-0338 155 µM -2.27312081630796 0.0337074880967505 no 3245 0.0115094501618019 4717 20969351
SGTC_1908 st060353 56.5 µM -2.27741906851497 0.0334449147135519 no 3246 0.0113806062375625 4727 4227716
SGTC_327 1273-0057 3.96 µM -2.28032802177889 0.0332681686782156 no 3247 0.0112941205256387 4689 3108138
SGTC_580 1123-0028 41 µM -2.28161048503824 0.0331904917858265 no 3248 0.0112561735686351 4757 1677248 YPR107C YTH1
SGTC_2983 9022671 12.99 µM -2.2831431385364 0.0330978572670361 no 3249 0.0112109691089299 4721 6405161
SGTC_887 0885-0007 9.62 µM -2.28406853828343 0.0330420287470198 no 3250 0.0111837516236568 4743 5719458
SGTC_3081 9117243 49.47 µM -2.28441500714721 0.033021146571903 no 3251 0.0111735762118272 4704 45595589
SGTC_2958 9077254 16.72 µM -2.29268360800489 0.0325260042142364 no 3252 0.0109331134689274 4719 16457351
SGTC_1605 st000082 49.1 µM -2.30492571926998 0.0318041789302345 no 3253 0.0105853669534267 4730 1114022
SGTC_2021 4019055 173 µM -2.30776102653575 0.0316389032614396 no 3254 0.0105062158576956 4560 44827708 YER133W GLC7
SGTC_3148 9097893 49.47 µM -2.30813658091281 0.0316170647828132 no 3255 0.0104957705701405 4710 17174100
SGTC_1218 1348-1416 30.7 µM -2.3169680440823 0.0311070958444207 no 3256 0.0102527362954214 4730 6787668
SGTC_2569 tetrandrine 100 µM -2.31989882124783 0.0309393707273514 no 3257 0.0101731756828994 4727 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2860 9025725 38.96 µM -2.32052623010721 0.030903562250523 no 3258 0.0101562138300434 4755 40546248
SGTC_3001 9076041 71.4286 µM -2.33841771203268 0.0298967795789281 no 3259 0.00968279490169759 4733 16004211
SGTC_660 4031-1742 102 µM -2.33969794592763 0.0298257939764644 no 3260 0.00964967070348417 4656 6738706
SGTC_2861 9024595 19.48 µM -2.3415558341019 0.0297230276925403 no 3261 0.00960177668012846 4739 16482810
SGTC_1853 st056710 91.2 µM -2.34282591829599 0.0296529441098023 no 3262 0.00956915519286235 4756 269167
SGTC_180 1486-1293 102.781 µM -2.34342704879693 0.029619821413002 no 3263 0.00955374925938284 4692 4140536
SGTC_2032 5185112 25.99 µM -2.34349720920095 0.0296159575291447 no 3264 0.0095519525835478 4689 5718189
SGTC_863 0466-0191 129 µM -2.34483722610119 0.0295422401825051 no 3265 0.0095176939250387 4770 765160 YPR165W RHO1
SGTC_2863 9028737 58.44 µM -2.35051128884451 0.0292317830830586 no 3266 0.00937381948391001 4748 6460917
SGTC_2597 laccaic acid a 100 µM -2.35547370595631 0.02896248973759 no 3267 0.00924955310268386 4715 5491415 A textile dye.
SGTC_2219 9098279 200 µM -2.35708358604436 0.0288755712491662 no 3268 0.00920955018453008 4738 902349
SGTC_1310 1188-0297 994 nM -2.35725962928221 0.0288660797240034 no 3269 0.00920518499279809 4687 1588352
SGTC_964 1287-0107 19.4 µM -2.35755007743536 0.0288504256270406 no 3270 0.00919798696013582 4735 51516812 YPR165W RHO1
SGTC_1382 3002-2117 298 µM -2.35859942474475 0.0287939284245109 no 3271 0.00917202254245572 4766 1497314
SGTC_2754 granisetron 64.02 µM -2.36032606458835 0.0287011657826624 no 3272 0.00912943923536062 4717 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1735 st034310 56.75 µM -2.36078319858585 0.028676648193863 no 3273 0.00911819417468349 4726 871153
SGTC_2013 4024628 200 µM -2.36707157714629 0.0283411460085804 no 3274 0.00896473244547334 4733 5230760
SGTC_587 k089-0003 57 µM -2.3726367668514 0.0280469587020768 no 3275 0.00883081153870421 4714 9659696
SGTC_1638 st008370 60.6 µM -2.3784399230619 0.0277429048448358 no 3276 0.0086930348756321 4706 24207134
SGTC_2144 5628481 200 µM -2.38442887422186 0.0274320013610439 no 3277 0.00855282714296977 4760 2818399
SGTC_163 TUB2.036 7.546 µM -2.38568574957561 0.0273671235824492 no 3278 0.00852365551398448 4700 15992207 YJR013W GPI14
SGTC_3265 9137266 49.47 µM -2.38794660762754 0.027250744031254 no 3279 0.00847140151512462 4737 17224265
SGTC_1855 st056195 39.6 µM -2.39457256516544 0.0269120430137371 no 3280 0.00831987523632816 4703 4028379
SGTC_979 1426-2828 121 µM -2.41211631265277 0.0260321887953942 no 3281 0.00793011048105138 4767 747872
SGTC_711 k292-0785 179 µM -2.41272347075398 0.0260021745314894 no 3282 0.00791691379298159 4702 4146315
SGTC_650 1328-0195 38 µM -2.41597653539358 0.0258418550987703 no 3283 0.0078465363060249 4750 2780821
SGTC_2703 st077852 53.4 µM -2.41611320607205 0.0258351377601172 no 3284 0.00784359162857296 4751 6281836
SGTC_1731 st035964 63 µM -2.41898857654223 0.0256941522254195 no 3285 0.00778186448368122 4670 6739575
SGTC_1847 st056231 15 µM -2.41967197305403 0.0256607387280767 no 3286 0.00776725665921577 4746 5393180
SGTC_1053 3366-3204 134 µM -2.42501663367535 0.0254006733714287 no 3287 0.00765384268361693 4749 3632071 YPR165W RHO1
SGTC_2137 5261020 140 µM -2.44466545820221 0.0244634850863744 no 3288 0.00724932798202365 4749 763655
SGTC_951 1171-0579 82.7 µM -2.45417184078183 0.0240205831485546 no 3289 0.00706047418878953 4708 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3100 9120536 49.47 µM -2.4680249415652 0.0233872448514521 no 3290 0.00679304264377504 4714 16421196
SGTC_1049 3226-0134 66 µM -2.49494320710382 0.0221967278186273 no 3291 0.0062988645719055 4752 5702385
SGTC_2724 maprotiline 69.64 µM -2.49767330055973 0.0220788917134131 no 3292 0.00625056721856232 4728 4011 A tricyclic antidepressant.
SGTC_744 1594-0068 283 µM -2.50015586317377 0.0219721983218226 no 3293 0.00620693384144837 4760 668392
SGTC_2792 7535235 81.82 µM -2.51946978599225 0.0211569161040065 no 3294 0.0058765863434046 4722 1281891
SGTC_1988 st071872 53.4 µM -2.52931316173132 0.020751346836616 no 3295 0.00571430021630672 4779 16414116
SGTC_485 niflumic acid 177 µM -2.53254905305541 0.0206194669059231 no 3296 0.00566182623858693 4781 4488 A COX2 inhibitor.
SGTC_3329 9141233 27.5565 µM -2.53266270455115 0.0206148479325204 no 3297 0.00565999104144107 4736 4909101 YNL103W MET4
SGTC_908 3448-7491 47.7 µM -2.54423681043657 0.0201490257235359 no 3298 0.00547584044230035 4768 1203031
SGTC_1570 verbenone 133 µM -2.5594684287057 0.0195496287394339 no 3299 0.00524161887226169 4761 29025 A natural terpanoid with antifungal properties.
SGTC_40 0327-0103 19.753 µM -2.56866726008982 0.0191950216706297 no 3300 0.00510452157167406 4666 409036
SGTC_809 3998-0021 90 µM -2.56888323126285 0.0191867622941006 no 3301 0.00510134150142692 4748 715485
SGTC_1989 st071868 50.2 µM -2.58207407052409 0.0186880009149212 no 3302 0.004910425215718 4769 16414057
SGTC_1808 st050063 61.5 µM -2.58638758795686 0.0185273146427422 no 3303 0.00484939004058488 4761 4011993
SGTC_1927 st060202 13.8 µM -2.58686414896099 0.0185096342701629 no 3304 0.00484268847901534 4745 688887
SGTC_1395 3486-0190 4.35 µM -2.59068231316767 0.018368498686762 no 3305 0.00478929351038092 4761 6748079
SGTC_2598 perillyl alcohol 100 µM -2.60608944855884 0.0178082615685529 no 3306 0.00457912707235641 4752 10819 An apoptosis inducer.
SGTC_310 1273-0058 1.06 µM -2.61347171890679 0.0175450331866314 no 3307 0.00448137505663728 4441 2734232
SGTC_933 2914-0560 114 µM -2.62508343080288 0.0171377191107819 no 3308 0.00433138689056576 4757 463887
SGTC_3004 9076122 71.4286 µM -2.63300766293443 0.0168644163174124 no 3309 0.00423162189331157 4774 44782551
SGTC_1712 st032288 53.4 µM -2.64357016960941 0.0165059226082009 no 3310 0.00410183797826093 4647 2883011
SGTC_2767 sibutramine 71.45 µM -2.65506468616736 0.0161232280321815 no 3311 0.0039646600864366 4763 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_3240 9133527 49.47 µM -2.66105166251221 0.0159269286473425 no 3312 0.00389485019743583 4780 17617455
SGTC_935 2996-0153 430 µM -2.67365838680611 0.0155202739310855 no 3313 0.00375144184538367 4771 23738523
SGTC_3065 9113888 49.47 µM -2.70092131764188 0.0146712342968778 no 3314 0.00345738474492077 4770 16648368
SGTC_2910 7948405 25.97 µM -2.71368882623857 0.0142875593715275 no 3315 0.00332693175753703 4775 2971328
SGTC_3248 9135562 49.47 µM -2.71387580661424 0.0142820052698945 no 3316 0.00332505460144596 4777 17650701
SGTC_967 1306-0166 352 µM -2.7212465249229 0.0140645405661173 no 3317 0.00325181201602518 4773 4437607
SGTC_3093 9117344 49.47 µM -2.76212879059601 0.0129094577967504 no 3318 0.00287129105734577 4785 24824913
SGTC_3017 9080681 49.47 µM -2.80933985282324 0.0116784718442282 no 3319 0.00248216054199479 4779 16451914
SGTC_2151 5563267 85.4165 µM -2.81023614204438 0.0116561231750086 no 3320 0.00247525813248706 4795 5310824
SGTC_894 0960-0238 55.9 µM -2.83764967921599 0.0109902788505364 no 3321 0.00227235163095203 4778 6741907 YDL195W SEC31
SGTC_2355 9061122 103.12 µM -2.83935380067835 0.0109500025931923 no 3322 0.0022602502298138 4774 5302957
SGTC_1938 st074717 56.4 µM -2.86357967071233 0.0103911727710423 no 3323 0.00209441728736493 4754 17250979
SGTC_363 0455-0021 3.06 µM -2.8708612928441 0.0102281378712017 no 3324 0.00204677552626195 4746 4597466
SGTC_710 3448-4187 58 µM -2.89427457943931 0.00971894161837435 no 3325 0.00190017836941798 4770 3946412
SGTC_456 gingerol 170 µM -2.95612680131638 0.00847887496045368 no 3326 0.00155764493317347 4781 442793 A herb.
SGTC_2944 9067346 25.62 µM -2.9798304802964 0.00804179809529404 no 3327 0.00144203970183253 4751 6473075
SGTC_1435 4092-0789 56.7 µM -2.9906330559011 0.00784926462260121 no 3328 0.0013919990632487 4797 2248285
SGTC_1226 3909-7979 35.4 µM -3.02181797836747 0.00731602193069452 no 3329 0.00125630793552509 4782 6615510
SGTC_3205 9113483 49.47 µM -3.05602104608734 0.00676813007268918 no 3330 0.00112147755694229 4761 17018033
SGTC_1831 st055328 12 µM -3.0585188843881 0.00672957628743553 no 3331 0.00111217029663639 4792 1103068
SGTC_1967 st070177 51.4 µM -3.08067407074976 0.00639602088434804 no 3332 0.00103266295690702 4798 5729214
SGTC_2295 7971645 200 µM -3.16034303829802 0.00531428490701943 no 3333 0.000787917429729033 4789 2978226 YKL099C UTP11
SGTC_1351 1496-0003 46.5 µM -3.23681832407804 0.00443221335662618 no 3334 0.000604351676820726 4803 3891978
SGTC_1825 st052143 62.6 µM -3.24296063207878 0.00436739239160329 no 3335 0.000591472776642818 4804 674173
SGTC_376 3970-0862 59.1 µM -3.26827640093963 0.00410908125940666 no 3336 0.000541023189254841 4800 3135186
SGTC_697 0508-1955 564 µM -3.28662367062813 0.0039305090213698 no 3337 0.000506981198670133 4802 6243113
SGTC_768 0384-0033 77.3 µM -3.31094302528914 0.00370453448916418 no 3338 0.000464910690343219 4794 3965305 YMR134W ERG29
SGTC_1319 1306-0155 43.7 µM -3.35994121495371 0.00328430698380559 no 3339 0.000389795293090814 4800 3122360
SGTC_3 0833-0587 95.581 µM -3.4656646262979 0.00252017224299135 no 3340 0.000264461301019447 4725 5382644
SGTC_1787 fluconazole 80 µM -3.50705452861135 0.00226770878002655 no 3341 0.000226548145381083 4617 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_694 1315-0438 43.2 µM -3.55877779783027 0.0019845061317228 no 3342 0.000186292286969369 4805 6793154
SGTC_256 clotrimazole 625 nM -3.58676125155327 0.00184505145899555 no 3343 0.000167405304655897 4792 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2406 ethylparaben 405.7 µM -3.73699008468498 0.00123742901558513 no 3344 9.31181323590734e-05 4784 8434 A possible steroid mimic.
SGTC_2024 5144227 134 µM -3.83223831316672 0.000953599774496076 yes 3345 6.34913206656934e-05 4797 3475211
SGTC_2777 climbazole 1.536 µM -3.89812600275255 0.000793694989895981 yes 3346 4.84699873454997e-05 4743 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2778 tioconazole 65.09 nM -3.91418783354455 0.000758652766871597 yes 3347 4.53545025672394e-05 4773 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_507 nimesulide 162 µM -3.91982416979613 0.00074669765791154 yes 3348 4.43067976526582e-05 4808 4495 A COX2 inhibitor.
SGTC_312 4092-0653 6.84 µM -4.00185647239098 0.000591246866508408 yes 3349 3.14237100656293e-05 4776 1148278
SGTC_2612 dictamnine 15.46 µM -4.04088231566253 0.000528320883587081 yes 3350 2.66252386086549e-05 4793 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_314 1671-0008 2.74 µM -4.12489743670599 0.00041331307954188 yes 3351 1.85450000875373e-05 4790 3913060
SGTC_217 ketoconazole 989 nM -4.22344007526285 0.000308154848697157 yes 3352 1.20300682248724e-05 4771 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_365 0121-0052 13.6 µM -4.54104384764507 0.000114735606983839 yes 3353 2.79881936094769e-06 4799 3101739
SGTC_41 0478-0632 82.643 µM -5.01804847779852 2.30711746064768e-05 yes 3354 2.60995034512646e-07 4805 3750424
SGTC_2405 ticlatone 3.52 µM -5.50894343298448 3.80407038329187e-06 yes 3355 1.80496939145065e-08 4797 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2896 9052656 71.43 µM -8.05485729319988 2.71613641316228e-11 yes 3356 3.97857955117998e-16 4783 6469436