SGTCid condition conc unit ZTA1|YBR046C.score ZTA1|YBR046C.strain.pval ZTA1|YBR046C.strain.significant ZTA1|YBR046C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_69 0096-0274 206.684 µM 5.35064008714707 5.67846431400362e-08 yes 1 4.38218383301793e-08 13 6741392
SGTC_2944 9067346 25.62 µM 5.26259521409166 9.13674479592495e-08 yes 2 7.10180320945671e-08 8 6473075
SGTC_3106 9121286 49.47 µM 4.7950427658431 1.0088242717468e-06 yes 3 8.13200650919151e-07 4 15943471
SGTC_1889 st059080 5.18 µM 4.62029714875588 2.34649638338406e-06 yes 4 1.91595417064246e-06 10 176925 Isolated from Daphnopsis sellowiana.
SGTC_1182 1222-0449 220 µM 4.54848631324753 3.291712718441e-06 yes 5 2.70165783979132e-06 10 658318
SGTC_308 4092-1169 104 µM 4.31830219463199 9.4258074014867e-06 yes 6 7.86170250305719e-06 43 2268590 YDL196W YDL196W
SGTC_1921 5740136 50 µM 4.15160348974393 1.9571207894463e-05 yes 7 1.6507695460532e-05 49 1774243
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 4.13649249325708 2.0884183443593e-05 yes 8 1.76327443135585e-05 28 5377381
SGTC_736 0958-0254 92.6 µM 4.08654138721592 2.58446374438295e-05 yes 9 2.18925704537693e-05 28 6812352
SGTC_626 0214-0009 33 µM 4.07915117551811 2.6667167576204e-05 yes 10 2.2600218729952e-05 15 3437874
SGTC_1965 Pectolinarigenin 58.4 µM 3.94973938019114 4.57747855569549e-05 yes 11 3.91181663592775e-05 15 5320438 An anti-inflammatory.
SGTC_1782 st039423 80.636 µM 3.77065621478388 9.42057953963296e-05 yes 12 8.14094220048216e-05 27 2068169
SGTC_1856 st057054 55.7 µM 3.72100960973137 0.000114463056599863 yes 13 9.92139432364593e-05 32 1266018
SGTC_1120 ficusin 1.78878 µM 3.70943896739383 0.000119738982099174 yes 14 0.000103859510382257 32 6199 A DNA cross-linker.
SGTC_2882 9058044 58.44 µM 3.44412116035522 0.000325168968379195 yes 15 0.000286459450504927 27 18076804
SGTC_3027 9089541 49.47 µM 3.43919014600024 0.000331057568898295 yes 16 0.00029172863514807 35 9943819
SGTC_254 nsc-64875 3.808 µM 3.42701195379879 0.000346028226804166 yes 17 0.000305131102437455 47 56993
SGTC_1435 4092-0789 56.7 µM 3.39401062471122 0.00038981840766122 yes 18 0.000344385101572773 28 2248285
SGTC_3054 9094397 49.47 µM 3.3320662246127 0.000486201412003735 yes 19 0.00043101870070206 54 2598354
SGTC_2823 7987624 58.44 µM 3.3162748620272 0.000514079998252455 yes 20 0.00045613028797792 63 2239440
SGTC_3032 9089427 49.47 µM 3.29076113355321 0.000562265941109525 yes 21 0.000499583583536103 27 17173707
SGTC_1864 st057645 30.4 µM 3.2780385479339 0.000587824060918686 yes 22 0.000522655598401088 25 688666
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 3.27010140979187 0.000604308172972497 yes 23 0.000537544676342987 92 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_656 4090-1979 187 µM 3.26627369950153 0.000612409371619846 yes 24 0.000544864340879774 42 22330961
SGTC_1221 2958-7315 257 µM 3.24012680993592 0.000670487151051183 yes 25 0.000597382762630311 39 4562705
SGTC_761 k216-0224 480 µM 3.21744592267429 0.000724938334762054 yes 26 0.00064668703070774 53 1340404
SGTC_1127 asiatic acid 681.4 nM 3.18041932995789 0.000822654308592186 yes 27 0.00073531039139422 55 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_550 4123-0385 25.7 µM 3.1750716343659 0.000837728899849998 yes 28 0.000748997578531046 61 5731123
SGTC_652 0437-0092 114 µM 3.12489420751854 0.000992068830882398 yes 29 0.000889345084142778 42 3091274
SGTC_1390 3413-2614 145 µM 3.11969679976955 0.00100946454371951 no 30 0.000905186408293453 54 3421432
SGTC_2404 5161160 200 µM 3.07943207980058 0.00115401203371543 no 31 0.00103697826841656 59 2831543
SGTC_330 1488-0319 80.1 µM 3.05905145016351 0.00123418918921681 no 32 0.00111019506707023 43 6846614
SGTC_319 1348-1596 45.5 µM 3.05519240614231 0.00124993276545195 no 33 0.00112458090395108 52 5380505
SGTC_1298 1079-1278 263 µM 3.04043415390219 0.00131185096833349 no 34 0.00118118670518961 52 2840950
SGTC_324 1315-0088 19.6 µM 3.02815393210013 0.0013654961845857 no 35 0.00123026358910925 33 6787421
SGTC_1377 2944-0135 198 µM 3.00996247141043 0.00144865409782416 no 36 0.00130639985530659 91 1894137
SGTC_1745 st081495 74 µM 3.00562359234852 0.0014691591529259 no 37 0.00132518430963896 141 13842402 YBL026W LSM2
SGTC_993 3909-8757 62.7 µM 2.98896641337123 0.00155036299767467 no 38 0.00139961450183374 65 4288324 YLR208W SEC13
SGTC_682 0kpi-0099 17 µM 2.95310317471308 0.00173925496066771 no 39 0.00157298398217777 128 1714895 YML126C ERG13
SGTC_3118 9124250 49.47 µM 2.92945267883788 0.00187504015460388 no 40 0.00169779755571319 47 1504786
SGTC_1621 st003705 32.4 µM 2.91670293773331 0.00195217299789693 no 41 0.00176876256108007 78 24207032
SGTC_2911 7942208 15.64 µM 2.90387377091347 0.00203268463671898 no 42 0.00184288364721272 46 1243384
SGTC_68 0986-0284 82.829 µM 2.90066234636341 0.0020533045542128 no 43 0.00186187444656588 141 423278 YIL048W NEO1
SGTC_2865 9030313 51.95 µM 2.874137397443 0.00223101103169154 no 44 0.00202566337341577 60 42562754
SGTC_748 act1.228 77.9 µM 2.81617146950466 0.00266876238335897 no 45 0.00242998601798216 150 4421505 YNR035C ARC35
SGTC_2725 haloperidol 53.21 µM 2.80635460070047 0.00275014508178358 no 46 0.00250527597486459 110 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1573 oleylamine 1.06 µM 2.7552860832337 0.00321075377361802 no 47 0.00293204182677478 102 5356789 An amine of the fatty acid oleic acid.
SGTC_92 0063-0024 660.874 µM 2.73414229937047 0.00342097443905217 no 48 0.00312715044126394 63 3594437
SGTC_85 0868-0259 160.055 µM 2.71267488562738 0.00364698564968386 no 49 0.00333712763492762 65 83173
SGTC_777 1315-0167 517 µM 2.69381734373753 0.00385647744333823 no 50 0.00353194321281221 87 4221767
SGTC_1413 3910-0535 34.4 µM 2.68580446083827 0.00394871275606469 no 51 0.00361777098934841 69 2876951
SGTC_262 fenpropimorph 62.5 µM 2.67959288177821 0.00402156780703387 no 52 0.00368558750562996 83 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2350 9023895 38.85 µM 2.66675327253425 0.00417598910121478 no 53 0.00382939372229423 108 2997209
SGTC_171 k064-0041 9.68 µM 2.64897062028989 0.00439861781537948 no 54 0.00403686750246706 81 53325
SGTC_1189 1431-2119 7.28 µM 2.64538736786425 0.00444474111426423 no 55 0.00407987233668976 125 3107275
SGTC_3330 9141424 71.43 µM 2.64100400537997 0.00450175052620343 no 56 0.00413303710567557 87 27261020
SGTC_2686 alizarin 95.37 µM 2.62567841275888 0.00470624013160821 no 57 0.00432382379826896 109 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_464 bw-b 70c 158 µM 2.59841707134747 0.00509054752620585 no 58 0.00468273319130754 115 5353454
SGTC_1477 0139-0234 16 µM 2.59500495232239 0.00514056507386334 no 59 0.00472947780366863 79 620880
SGTC_665 3914-0008 307 µM 2.59427270313268 0.00515135580097643 no 60 0.0047395633884078 108 1069549
SGTC_751 0833-0568 350 µM 2.58322592675068 0.00531660954490482 no 61 0.00489406011106797 101 6954252
SGTC_2105 5350118 200 µM 2.55978142175794 0.00568303103764074 no 62 0.00523690078911787 106 2133313
SGTC_174 3553-0389 74.3 µM 2.55515838574342 0.005757877060025 no 63 0.00530697446217239 105 738071
SGTC_577 r071-0003 38.6 µM 2.54681234867181 0.00589521547898478 no 64 0.00543559369841122 180 4568517 YMR134W ERG29
SGTC_919 tnp00227 403.569 nM 2.52822445856227 0.00621157733737218 no 65 0.00573205168754885 143 1269246 A methoxyflavone. YNL221C POP1
SGTC_2749 bexarotene 57.39 µM 2.52030279130988 0.00635091031195871 no 66 0.00586269607898248 129 82146 An retinoic acid receptor inhibitor.
SGTC_2694 st077685 81.9 µM 2.51071281027978 0.00652328336389389 no 67 0.00602438371876287 133 2838096
SGTC_712 r015-0009 80.6 µM 2.50108783052854 0.00670043318933666 no 68 0.00619062341384677 96 6813872 YLR060W FRS1
SGTC_226 1,3-diallylurea 8.28947 mM 2.49242980893171 0.00686340459451506 no 69 0.00634362021816533 88 74537 YKL182W FAS1
SGTC_229 benomyl 22.8748 µM 2.4912626522931 0.00688563983790529 no 70 0.00636449911212993 108 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2109 5483026 200 µM 2.48274462841516 0.00704985002919584 no 71 0.0065187257573455 135 759335
SGTC_680 0417-1641 114 µM 2.4690210123851 0.00732168833038461 no 72 0.00677416313404273 105 2835990
SGTC_778 3456-2434 196 µM 2.4502815714088 0.00770778629419481 no 73 0.00713722702970323 200 5539063
SGTC_203 k066-0004 30.888 µM 2.44323105989234 0.00785762615208696 no 74 0.00727820716694484 139 6795412
SGTC_276 colchicine 750 µM 2.44216299522285 0.00788054710450997 no 75 0.00729977668007003 128 2833 A microtubule depolymerizer.
SGTC_2950 9072895 21.46 µM 2.42180408753755 0.00832883997466254 no 76 0.00772183697594874 178 17332245
SGTC_1931 st074438 57.1 µM 2.41684535001085 0.00844136288964946 no 77 0.00782783355791723 107 2787313
SGTC_3175 9106517 49.47 µM 2.3941669045214 0.00897315393124851 no 78 0.00832908326001331 103 41468073
SGTC_1843 st055809 45.5 µM 2.37985606463392 0.00932363689220784 no 79 0.00865970078828764 120 16413835
SGTC_825 1988-2224 89.6 µM 2.37939061551983 0.00933523444734989 no 80 0.00867064445235472 156 1180859
SGTC_1028 k015-0029 4.8 µM 2.37819708599669 0.00936503121229271 no 81 0.00869876222438975 172 4588309
SGTC_907 3448-6986 75.5 µM 2.36093616397416 0.00980534866210732 no 82 0.00911443408078706 161 590582
SGTC_1985 st071382 65.5 µM 2.36071921670139 0.00981099603451326 no 83 0.00911976733781087 130 6123237
SGTC_157 1348-1695 65.819 µM 2.35994229553615 0.00983124344368954 no 84 0.00913888896154588 215 5380510
SGTC_1789 tunicamycin 25 nM 2.34969723355027 0.010101674009737 no 85 0.00939434348251624 167 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2908 7930301 100 µM 2.30595444788469 0.011330629684346 no 86 0.010556588883629 181 2223178
SGTC_1657 st012939 43.4 µM 2.3044358354702 0.0113755335397199 no 87 0.0105990951654443 120 24207257
SGTC_1529 apigenin 74 µM 2.29908057839095 0.0115351194698142 no 88 0.0107501820657895 182 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2928 9011484 9.79 µM 2.29619432964901 0.011621932933422 no 89 0.0108323863106871 134 2994751
SGTC_3253 9135987 49.47 µM 2.29474306074123 0.0116657985655605 no 90 0.0108739267393504 99 4182430
SGTC_2489 cantharidin 73.42 µM 2.29030816673087 0.0118007382429565 no 91 0.0110017293674065 215 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_819 1013-0258 27.7 µM 2.28919389735156 0.0118348540519991 no 92 0.0110340445120854 172 5753198
SGTC_3062 9077494 49.47 µM 2.27532308032724 0.012266755102186 no 93 0.0114432779386758 155 16459633
SGTC_2549 cedrol 20.94 µM 2.27213863296149 0.0123678165166373 no 94 0.0115390691811251 125 6708665 A sedative which affects the nervous system.
SGTC_187 1488-2104 32.728 µM 2.24149454630783 0.0133777656639587 no 95 0.0124970291993841 171 2852859
SGTC_1442 4112-3290 3 µM 2.22255251535462 0.0140370318682586 no 96 0.0131229945791046 164 704353
SGTC_1531 st059297 52.4 µM 2.21681474701247 0.014242178339383 no 97 0.0133178766801148 163 7566702
SGTC_1439 4092-1168 46 µM 2.20984331345175 0.0144949035584773 no 98 0.0135580192582362 135 2886240
SGTC_3137 9097352 49.47 µM 2.2008093765221 0.0148281325422692 no 99 0.0138747607618525 228 44120435
SGTC_82 0054-0107 293.755 µM 2.19895385276472 0.0148973856454127 no 100 0.0139406018934007 117 3104697
SGTC_414 piperonyl butoxide 100 µM 2.1952334564534 0.0150370788895435 no 101 0.0140734277454803 129 5794 A potent inhibitor of cytochrome P450.
SGTC_579 4491-1009 110 µM 2.18677264736618 0.0153589620278572 no 102 0.0143795625983756 229 1271041
SGTC_816 0325-0417 81.3 µM 2.17163544578572 0.0159496145731506 no 103 0.0149415856092212 150 68101
SGTC_2119 5528445 120.635 µM 2.164209334485 0.0162464316715792 no 104 0.0152241436111637 171 791935
SGTC_3346 9158254 43.5805 µM 2.16222264852999 0.0163266359802886 no 105 0.0153005093032757 177 17639500
SGTC_1514 1189-1591 158 µM 2.16175504685562 0.0163455627051325 no 106 0.0153185310723801 227 767698 YMR146C TIF34
SGTC_3081 9117243 49.47 µM 2.16100099703866 0.0163761233338711 no 107 0.0153476311986391 159 45595589
SGTC_902 1120-0002 2.07 µM 2.15950427866625 0.0164369282857038 no 108 0.015405532873915 222 3280475
SGTC_1136 pergolide 1.05886 µM 2.14893890218621 0.0168716749187493 no 109 0.0158196217526023 280 47811 A dopamine receptor agonist.
SGTC_2926 9010726 65.15 µM 2.1411398208342 0.0171988682978634 no 110 0.0161313821366092 203 2994293
SGTC_9 0092-0002 10.449 µM 2.12660897157469 0.01782295117513 no 111 0.0167262932245944 181 759368
SGTC_31 0508-1974 57.237 µM 2.12443231610841 0.0179180797256217 no 112 0.0168170050697323 174 6810525
SGTC_2168 5727979 200 µM 2.11490136515714 0.0183397356828432 no 113 0.0172191774110768 158 695210
SGTC_1601 4'-hydroxyflavanone 55.5 µM 2.11117563318621 0.0185068476405646 no 114 0.0173786092095686 225 165506
SGTC_3245 9134821 49.47 µM 2.10893856768475 0.0186078094397928 no 115 0.0174749423064691 201 17014901
SGTC_2481 5478948 45.16 µM 2.10666735566606 0.0187107916158275 no 116 0.0175732118788683 220 77792
SGTC_3103 9120822 49.47 µM 2.10544122643313 0.0187665885842458 no 117 0.0176264591663901 180 17141819
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 2.10331365220145 0.018863743264266 no 118 0.0177191804146114 150 364106
SGTC_3280 9140961 49.47 µM 2.10231007364102 0.0189097195321742 no 119 0.0177630613607253 155 4901226
SGTC_3333 9141820 12.094 µM 2.10228963572047 0.0189106568303595 no 120 0.0177639559604938 156 1939433
SGTC_1016 4226-1401 38 µM 2.08948192892043 0.0195058527391818 no 121 0.0183321814972502 201 2901613
SGTC_323 4013-0906 34.3 µM 2.08653472004857 0.0196450443954685 no 122 0.0184651067761451 150 2910086
SGTC_956 1185-0240 191 µM 2.08089228976818 0.019913880445187 no 123 0.0187218830220316 197 1416193
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 2.06576852108304 0.0206499001775881 no 124 0.0194251708873487 211 1377
SGTC_3031 9088762 49.47 µM 2.06391401364228 0.0207417186704793 no 125 0.0195129349066722 203 205253
SGTC_1836 st055642 81 µM 2.0607661170339 0.0208983655904083 no 126 0.0196626792261447 225 8571
SGTC_1409 3909-8004 61.9 µM 2.03844822816028 0.0220379244031082 no 127 0.0207525636546888 253 2119279
SGTC_618 k072-0232 33.2 µM 2.03414608356983 0.0222635189843841 no 128 0.0209684343853038 179 5872756 YGL099W LSG1
SGTC_2699 st077704 54.6 µM 2.02475741023935 0.0227626115549995 no 129 0.0214461401564011 245 645852
SGTC_317 4495-0002 170 µM 2.01389503094749 0.0233517769662859 no 130 0.0220102776822878 179 15991618
SGTC_1956 st077085 54 µM 2.01107190283519 0.023506985080568 no 131 0.0221589312331066 237 24208685
SGTC_2398 5228213 48.84 µM 2.00355055713825 0.0239247299953823 no 132 0.0225591133637679 295 80771 YMR134W ERG29
SGTC_1341 1486-1360 280 µM 2.00303893166598 0.0239533715405949 no 133 0.0225865549454064 223 3976547
SGTC_3200 9114385 49.47 µM 1.97408947956911 0.0256215929511048 no 134 0.0241857846900899 229 17018030 YLR208W SEC13
SGTC_821 1114-0266 29.2 µM 1.97116003289996 0.0257956959343121 no 135 0.0243527869125078 219 3123235
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.96619931348268 0.0260927791367466 no 136 0.0246377958788485 276 65057 A dermal irritant. YDR527W RBA50
SGTC_2037 5169046 200 µM 1.95437887249271 0.0268122193800329 no 137 0.0253282136994298 203 5718022
SGTC_2777 climbazole 1.536 µM 1.95155715951614 0.0269863879143311 no 138 0.0254954018423555 268 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_235 0330-0087 5 mM 1.95072521180974 0.027037919280968 no 139 0.0255448712855875 253 46494818 YHR062C RPP1
SGTC_1986 st071812 45 µM 1.94681910666452 0.0272809650843869 no 140 0.0257782127308225 176 11838594
SGTC_231 b-estradiol 524 µM 1.93531201954016 0.0280075730087645 no 141 0.0264760091330748 174 450 A steroid.
SGTC_3151 9099821 49.47 µM 1.93309322177601 0.0281495150058202 no 142 0.0266123574711693 223 17174189
SGTC_469 w7 172 µM 1.9317564516132 0.0282353202529641 no 143 0.0266947867296729 138 45115570 A P450 inhibitor.
SGTC_1170 0310-0127 64.8 µM 1.92899269982167 0.0284134117508054 no 144 0.0268658842543358 269 774975
SGTC_953 1188-0045 9.7 µM 1.92592286194755 0.0286123215803249 no 145 0.0270570031670189 269 6144426
SGTC_2934 9036370 36.88 µM 1.92161826096585 0.0288931871475217 no 146 0.0273269045626382 269 6462800
SGTC_1470 k295-0292 231 µM 1.92039420753574 0.0289734711004647 no 147 0.0274040623315786 248 5045612
SGTC_1380 2291-0730 164 µM 1.91981023629252 0.0290118382309541 no 148 0.0274409367105929 236 2999191
SGTC_2302 7771753 200 µM 1.91806908914946 0.0291264829325844 no 149 0.0275511256522377 298 2203047
SGTC_3276 9139060 49.47 µM 1.91478212075632 0.0293439372140288 no 150 0.0277601477710935 164 4870619
SGTC_1804 st050076 49.1 µM 1.90665507779858 0.0298873866263571 no 151 0.0282826338789786 243 3895976
SGTC_1289 0976-0073 69.1 µM 1.90148455678705 0.0302374612996712 no 152 0.0286192867001795 237 3391136
SGTC_2165 5727197 32.143 µM 1.8888003990759 0.0311106678305112 no 153 0.0294592896496934 280 1361712
SGTC_1244 0416-0015 52.5 µM 1.88503251335187 0.0313740411811817 no 154 0.0297127241560941 280 96201
SGTC_3083 9117465 49.47 µM 1.87578700148314 0.0320281171536936 no 155 0.0303422667915912 277 16420915
SGTC_879 0831-1030 162 µM 1.87381030876097 0.0321694098754006 no 156 0.030478287516393 334 1549252
SGTC_1431 4049-0260 9.09 µM 1.85928988976913 0.0332231660758319 no 157 0.0314930296425816 256 3854841
SGTC_2614 arthonioic acid 13.39 µM 1.85900369501671 0.0332442177644892 no 158 0.0315133073192396 241 6710684
SGTC_1209 2323-2347 50.3 µM 1.85708857137862 0.0333853718407693 no 159 0.0316492769540722 230 5412760
SGTC_1425 4048-4433 7.33 µM 1.85316917870795 0.0336757890887879 no 160 0.0319290569170839 282 23734946
SGTC_837 0091-0265 12.5 µM 1.85232268167815 0.0337387846316224 no 161 0.0319897502885928 274 759367
SGTC_1004 4084-0029 199 µM 1.84879655421346 0.0340022398864738 no 162 0.0322435975581837 262 716894 YLR208W SEC13
SGTC_123 0083-0120 66.675 µM 1.84323785196946 0.0344209932782101 no 163 0.0326471452840017 292 16001701
SGTC_2146 5545642 200 µM 1.84217731981325 0.0345013656796373 no 164 0.0327246084116445 240 825326
SGTC_793 0488-0545 106 µM 1.84191318781815 0.0345214068791383 no 165 0.0327439246300488 260 292548
SGTC_1607 st000305 50.6 µM 1.83897945092684 0.0347446499037816 no 166 0.0329591042830516 264 5457690
SGTC_463 ikarugamyin 104 µM 1.83842335349335 0.0347870995605334 no 167 0.0330000232458296 162 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2624 nerol 100 µM 1.83506356637443 0.0350444753667529 no 168 0.0332481357298382 226 637566 A natural product oil.
SGTC_2959 9079155 11 µM 1.83438022590556 0.0350970132948478 no 169 0.0332987864029671 229 16189457
SGTC_2406 ethylparaben 405.7 µM 1.83302869275523 0.0352011148552897 no 170 0.0333991521032741 258 8434 A possible steroid mimic.
SGTC_2977 9011197 71.43 µM 1.82200034593373 0.0360600709004512 no 171 0.0342274665805168 210 2704722
SGTC_1145 3546-0597 10.2 µM 1.8216160180857 0.0360903115514292 no 172 0.0342566343674852 300 875334
SGTC_877 0771-0151 33.1 µM 1.80899468435735 0.0370950113070658 no 173 0.0352259145894335 286 6166523
SGTC_18 0111-0177 500 nM 1.80889337542782 0.0371031673754335 no 174 0.0352337848940898 401 721752
SGTC_3084 9116877 49.47 µM 1.80433267152473 0.0374718562829394 no 175 0.0355895854635761 203 27241325
SGTC_714 4296-0578 26.1 µM 1.79246973334 0.0384448889478968 no 176 0.0365288766239386 146 1589775
SGTC_2897 9048598 12.99 µM 1.78827655253131 0.0387937137858594 no 177 0.0368657004272731 255 6467404
SGTC_2247 cerulenin 830 nM 1.78115035248998 0.0393924429819498 no 178 0.0374439458900285 293 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.77467155883853 0.0399432826192307 no 179 0.0379760670300266 291 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1779 st039427 55 µM 1.77222205631301 0.0401531680950939 no 180 0.038178851855846 359 1124498
SGTC_704 1310-0270 142 µM 1.77109572757727 0.0402499777592695 no 181 0.0382723921859472 346 5718033
SGTC_1347 1493-0251 600 nM 1.77026162354668 0.0403217923806437 no 182 0.0383417839491161 303 3986378
SGTC_2972 9093619 59.92 µM 1.76990364799634 0.0403526452272037 no 183 0.0383715965126088 294 25236256
SGTC_301 4119-0100 24.5 µM 1.76962806538746 0.0403764099293702 no 184 0.0383945601805949 357 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2135 5326629 150.42 µM 1.76640139279418 0.0406555065416398 no 185 0.0386642658028454 292 5020077
SGTC_2701 st077767 14.721 µM 1.7656393532716 0.0407216485058525 no 186 0.038728186675926 351 5721188
SGTC_928 2764-0428 58.7 µM 1.76395420828907 0.0408682223804212 no 187 0.0388698445425513 344 662578
SGTC_2728 chlorpromazine 9.18 µM 1.76342338359019 0.0409144820479816 no 188 0.0389145544106418 183 2726 A thorazine and dopamine antagonist.
SGTC_1947 st076332 61.6 µM 1.76326747059751 0.0409280774318141 no 189 0.038927694476614 237 24208416
SGTC_2846 9008642 19.48 µM 1.76273213352883 0.0409747859321924 no 190 0.0389728392234684 272 2992898
SGTC_2552 juarezic acid 87.02 µM 1.76155566915653 0.0410775851147066 no 191 0.0390721997530995 365 1549512
SGTC_3101 9120531 49.47 µM 1.76148353181045 0.041083895258342 no 192 0.0390782989536311 317 24824904
SGTC_2872 9044037 25.97 µM 1.74822956208647 0.042256680529931 no 193 0.0402121422927103 213 6465195
SGTC_1098 clofazimine 15.1 µM 1.74815840237385 0.0422630494856867 no 194 0.0402183011865611 352 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2013 4024628 200 µM 1.74116349688621 0.042892909759804 no 195 0.0408274618783104 314 5230760
SGTC_2173 5763948 167 µM 1.73619273988059 0.043345098487343 no 196 0.0412648802775332 312 2867177
SGTC_156 3474-0145 5.642 µM 1.73164400469135 0.0437622613529985 no 197 0.0416684830786008 328 2265471
SGTC_1520 flindersine 88 µM 1.72485949603451 0.0443904785092803 no 198 0.0422763982640433 324 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2200 6600604 21.907 µM 1.72280604902376 0.0445820452528358 no 199 0.0424618022640804 353 2904777
SGTC_2837 9008476 45.46 µM 1.72262919848574 0.044598574795761 no 200 0.0424778006593518 356 2992805
SGTC_421 streptovitacin 30 mM 1.71120650056257 0.0456767098451311 no 201 0.0435214995478533 368 91467 include heat shock
SGTC_940 3232-1287 54.8 µM 1.70850616931467 0.0459346192868836 no 202 0.0437712313216422 319 1585493 YIL048W NEO1
SGTC_1954 st077032 68.9 µM 1.70677654981094 0.0461004296124664 no 203 0.0439317963340754 295 698907
SGTC_2043 5101342 149 µM 1.70655592748682 0.0461216141452917 no 204 0.0439523113877976 335 678451
SGTC_890 0929-0006 47.2 µM 1.7059852935574 0.0461764436581778 no 205 0.0440054088797333 282 1378169
SGTC_995 3931-2021 34.6 µM 1.70418504528289 0.0463497641452291 no 206 0.0441732610866558 320 730143
SGTC_984 1492-0255 2.91 µM 1.70219473987789 0.0465419900542593 no 207 0.0443594342546361 302 1585198
SGTC_2568 diosmetin 100 µM 1.69839179790439 0.0469110613260818 no 208 0.0447169195594643 340 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1862 st057513 3.81 µM 1.69621593082109 0.0471232802075597 no 209 0.0449224972784264 302 5393163
SGTC_378 3970-0959 8.33 µM 1.69600829028936 0.0471435721792432 no 210 0.0449421550290862 315 6615653
SGTC_2965 9082772 38.63 µM 1.69500029168507 0.0472421798659975 no 211 0.0450376827245004 349 16459634
SGTC_3349 9149703 23.001 µM 1.69492085128312 0.0472499581632451 no 212 0.0450452182070973 301 4910494
SGTC_471 1-acyl-paf 4 µM 1.69116787949277 0.0476185964090479 no 213 0.0454023719112913 338 16759367
SGTC_1572 epiandrosterone 68.9 µM 1.68565755361819 0.048164022230249 no 214 0.0459308884509703 346 441302 A steroid.
SGTC_119 0121-0043 24.815 µM 1.68161129611752 0.0485677049641786 no 215 0.0463221193573193 536 1092378
SGTC_1939 st074455 53.6 µM 1.68081281312522 0.0486476858634374 no 216 0.0463996395301351 353 1644229
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.66682835550328 0.050065597276237 no 217 0.0477742700970648 334 688662
SGTC_1943 st076331 65.2 µM 1.66576589148033 0.0501746555817235 no 218 0.0478800260953771 320 24208415
SGTC_1373 2887-0003 58.5 µM 1.66514214970176 0.0502387687174883 no 219 0.0479421996296089 349 776948
SGTC_560 2332-1943 155 µM 1.66496703456435 0.0502567801775772 no 220 0.0479596664264832 311 21177716
SGTC_2662 daunorubicin 22.37 µM 1.66304734019088 0.0504545679131152 no 221 0.0481514798314723 296 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1619 st003326 88.7 µM 1.65951637919923 0.0508199848908091 no 222 0.0485058914567217 297 2849032
SGTC_2333 9017922 200 µM 1.65883465782488 0.0508907779183716 no 223 0.0485745572274556 336 3163164
SGTC_2464 5717415 7.67 µM 1.65834048892686 0.0509421437142857 no 224 0.0486243805138445 353 5285744
SGTC_1746 st038117 42 µM 1.65420289425132 0.0513738421336759 no 225 0.0490431475031662 365 2898218
SGTC_810 3825-7150 143 µM 1.65282903191467 0.0515178266878356 no 226 0.0491828318706226 339 22330411 YGL099W LSG1
SGTC_99 0109-0120 622.8 µM 1.64972753872543 0.0518440516295459 no 227 0.0494993375290452 299 759414
SGTC_2170 morpholine 200 µM 1.64743646358331 0.0520860868482179 no 228 0.0497341828329155 297 121171 Reacts with secondary amines.
SGTC_715 0868-0130 184 µM 1.64476513874101 0.0523694251321905 no 229 0.0500091269524382 300 2876258
SGTC_21 0849-0113 22.993 µM 1.64108563530618 0.0527616995666962 no 230 0.0503898200748344 361 1560156
SGTC_1368 1852-0141 284 µM 1.640975990559 0.0527734245419066 no 231 0.0504011996030617 359 2838987
SGTC_789 1309-1135 70.6 µM 1.63912685200657 0.0529714756759722 no 232 0.0505934219074493 395 3092424
SGTC_362 0310-0100 9.03 µM 1.63835051963295 0.0530547998900828 no 233 0.050674297332942 367 790235
SGTC_1787 fluconazole 80 µM 1.63803683957836 0.0530884968238986 no 234 0.0507070045493811 443 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_616 4092-0450 108 µM 1.63294995722956 0.0536373252591241 no 235 0.051239760990485 375 787165
SGTC_1645 Cervolide 78 µM 1.63152304537783 0.0537920805773608 no 236 0.0513900006056098 302 23173 A fragrance.
SGTC_585 0kpi-0023 191 µM 1.62895388071674 0.0540716098542617 no 237 0.0516613912540209 325 64601
SGTC_2114 5491910 81.25 µM 1.62870424654371 0.05409883162785 no 238 0.0516878216827586 337 2849228
SGTC_3077 9117319 49.47 µM 1.62677550271212 0.0543095205192611 no 239 0.0518923931481155 279 17154678
SGTC_3065 9113888 49.47 µM 1.62536425979048 0.0544640903819292 no 240 0.0520424832921257 322 16648368
SGTC_2483 5729050 27.16 µM 1.62209743198241 0.0548232327581888 no 241 0.0523912439763159 453 2865180
SGTC_1093 fluphenazine 7.97 µM 1.62137915080636 0.0549024482891489 no 242 0.0524681746797645 403 6602611 An atypical antipsychotic.
SGTC_2001 4023502 57.655 µM 1.62061324354268 0.0549870158832282 no 243 0.0525503050830171 381 108941 YCR052W RSC6
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.61904695237679 0.0551602782697275 no 244 0.0527185806051273 331 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2477 5967686 25.23 µM 1.61721413398672 0.0553635710469659 no 245 0.0529160332200027 369 776118
SGTC_693 4161-2696 114 µM 1.61052864416036 0.0561101319705415 no 246 0.0536412486707165 298 805759
SGTC_2836 9010338 19.48 µM 1.60884706036201 0.0562991565180237 no 247 0.0538248938511706 351 2994051
SGTC_2802 7925815 54.55 µM 1.60689101062092 0.0565196645988842 no 248 0.0540391393572536 399 1262923
SGTC_1574 spiramycin 23.7 µM 1.60660649689027 0.0565517948277795 no 249 0.0540703582112816 397 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1774 st048371 48.465 µM 1.60188146293149 0.057087501429912 no 250 0.0545909121878371 399 4242727
SGTC_488 nitrendipine 139 µM 1.59582335016303 0.0577801825789105 no 251 0.0552641192441267 374 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2029 5175081 200 µM 1.59036099142207 0.0584103951251783 no 252 0.0558767289425001 405 1380876
SGTC_2793 7325131 81.82 µM 1.58933882091199 0.0585289241060044 no 253 0.055991959361554 348 4176441
SGTC_170 4197-0004 226 µM 1.58878223113442 0.0585935445840959 no 254 0.0560547831181616 322 218692
SGTC_3125 9127534 49.47 µM 1.58841805281124 0.0586358562577392 no 255 0.0560959189645461 264 1639235
SGTC_1854 st056233 32.9 µM 1.58640265339077 0.0588704471283211 no 256 0.0563239994533562 342 5393174
SGTC_121 0557-0495 61.343 µM 1.58149210526358 0.059445114352918 no 257 0.0568827813231716 549 3104427
SGTC_3170 9103054 49.47 µM 1.58052781656513 0.0595584770989813 no 258 0.0569930209041352 342 16432970
SGTC_762 1165-0429 115 µM 1.57391383719113 0.0603405955306801 no 259 0.057753685245564 388 5967793
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.56952283397421 0.0608642660339891 no 260 0.0582630815908459 362 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1422 4031-0024 15.5 µM 1.56571927975185 0.0613207437409359 no 261 0.0587071753398783 373 782427
SGTC_2685 mycophenolic acid 18.85 µM 1.56087596367074 0.061905873142497 no 262 0.0592765097954808 326 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_26 0302-0163 425.158 µM 1.55726493428202 0.0623449564810691 no 263 0.0597037985700035 358 3100915
SGTC_246 cycloheximide 667 µM 1.55491774958739 0.0626316624357892 no 264 0.0599828297543806 330 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_578 3460-0051 92 µM 1.55056092746099 0.06316656637944 no 265 0.0605034709167294 443 2876744
SGTC_2367 9070478 135.38 µM 1.54976605453128 0.0632645386117893 no 266 0.0605988386546538 422 572802
SGTC_2017 5132927 60.65 µM 1.54887800869739 0.0633741347706975 no 267 0.0607055241798681 408 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2340 7987427 183.45 µM 1.54554514751643 0.0637867708527023 no 268 0.0611072286646342 394 2239331
SGTC_2848 9016370 25.97 µM 1.54383757629779 0.0639989905664793 no 269 0.0613138428537101 453 7894410
SGTC_2681 menadione 3.18 µM 1.54227621615564 0.0641935190629015 no 270 0.0615032429939024 399 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1460 k062-0059 9.15 µM 1.54023180199339 0.0644489253486129 no 271 0.0617519302979637 371 1373085
SGTC_2648 atorvastatin 78.68 µM 1.5375134035043 0.0647897537132538 no 272 0.0620838176596799 357 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2133 5320837 200 µM 1.53584878633568 0.0649991505787915 no 273 0.0622877356036436 392 2841355
SGTC_22 0964-0034 14.468 µM 1.53079630326847 0.065637934213962 no 274 0.0629098717717533 454 138402
SGTC_1335 1486-0900 202 µM 1.52863949856549 0.0659120961284516 no 275 0.0631769192328675 454 X1335
SGTC_162 k030-0015 37.8 µM 1.52724583473471 0.0660897229372348 no 276 0.0633499463945935 392 1809920 YMR134W ERG29
SGTC_2652 actinonin 100 µM 1.52691148554301 0.066132391891797 no 277 0.0633915115741483 343 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.52223879839383 0.0667309460659357 no 278 0.0639746284163466 423 5393153
SGTC_552 k242-0005 476 µM 1.52039706528461 0.0669680139044755 no 279 0.0642056058098642 360 4088318
SGTC_1328 1441-0025 69.2 µM 1.51928811676608 0.0671110716315306 no 280 0.0643449947767332 360 4562601
SGTC_3221 9128209 49.47 µM 1.51781348470053 0.0673016695743439 no 281 0.0645307123522375 369 16460723
SGTC_2217 6934799 96.0675 µM 1.51369881707192 0.0678357082318075 no 282 0.065051122562668 381 675606
SGTC_2619 obliquin 87.91 µM 1.51338610353305 0.0678764284523341 no 283 0.0650908063864278 544 6708593 A bioactive alkalod. YER133W GLC7
SGTC_260 nsc-65238 3.989 µM 1.50986031809725 0.0683368483705619 no 284 0.0655395349976884 387 3246252
SGTC_1567 st069303 68.4 µM 1.50766062589372 0.0686253168986426 no 285 0.0658207038439522 449 5581319
SGTC_1497 4476-2978 41.3 µM 1.50623521141549 0.0688127472170171 no 286 0.0660034016531295 458 1528379
SGTC_189 3970-0742 2.116 µM 1.50599226453996 0.0688447320700164 no 287 0.0660345797234789 374 2891807
SGTC_1515 3460-0031 42.1 µM 1.49418484012366 0.070413079450177 no 288 0.0675636569269954 360 2876596
SGTC_2171 5739187 198.077 µM 1.49054428718307 0.0709021437033838 no 289 0.0680405903968179 367 2262761
SGTC_2068 5226020 147 µM 1.48968234647443 0.0710183161615955 no 290 0.0681538892607487 474 1810509
SGTC_1277 0873-0036 22 µM 1.48689285418109 0.0713952864812991 no 291 0.0685215559362514 478 5965735
SGTC_47 0149-0135 24.25 µM 1.48420263843287 0.0717602935804263 no 292 0.0688775850296797 399 5239155
SGTC_208 k072-0098 12.366 µM 1.47988008091328 0.0723497712604657 no 293 0.0694526261931337 519 5948901
SGTC_305 1682-2595 20.8 µM 1.47912583190665 0.0724530091545376 no 294 0.0695533436920088 437 226033
SGTC_1401 3807-4679 7.6 µM 1.47875342903358 0.0725040234271227 no 295 0.0696031133996539 389 3291456
SGTC_3251 9135047 49.47 µM 1.47061065566375 0.073626366618002 no 296 0.0706982202950628 356 17682963
SGTC_2044 5102272 200 µM 1.46663288783838 0.0741794410682504 no 297 0.0712379742346592 384 592666
SGTC_3076 9116187 49.47 µM 1.46599537728645 0.0742683757117958 no 298 0.0713247731171921 405 27241210
SGTC_1108 betulinic acid 729.144 nM 1.46335609813041 0.0746374296539226 no 299 0.0716849824717232 444 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1615 st002656 86.5 µM 1.46287503599091 0.0747048477625931 no 300 0.0717507880325913 421 1584458
SGTC_209 4077-0173 175.592 µM 1.46193787541691 0.074836318890808 no 301 0.0718791173594061 328 15993494
SGTC_2097 5376186 200 µM 1.46101473244539 0.074965996042281 no 302 0.0720056992094532 458 742755
SGTC_207 4185-0010 4.486 µM 1.46090005269213 0.0749821174731415 no 303 0.072021436084783 521 3761753
SGTC_2142 5622915 118.518 µM 1.45190424074124 0.0762549860896424 no 304 0.0732641166229099 397 5322196
SGTC_79 0052-0007 94.094 µM 1.44642461256243 0.0770383496475534 no 305 0.0740290713122223 452 2801472
SGTC_2569 tetrandrine 100 µM 1.44333847705631 0.0774822254095726 no 306 0.0744625729182839 408 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2138 5575593 77.673 µM 1.43975084277118 0.0780006694056508 no 307 0.0749689516304948 375 762213
SGTC_201 4262-0159 12.803 µM 1.43868729532406 0.0781548658190748 no 308 0.075119570258659 383 1341029
SGTC_3012 9080433 71.4286 µM 1.43642623466702 0.0784834495652012 no 309 0.0754405462307868 470 17688859
SGTC_1697 st025554 27.742 µM 1.43564548055036 0.0785971538844254 no 310 0.0755516230770498 423 1269519
SGTC_1314 1222-0010 41.1 µM 1.43519075849324 0.0786634343720549 no 311 0.0756163731777522 448 3526027
SGTC_1840 st055363 71 µM 1.43516943296306 0.0786665438302919 no 312 0.0756194108620117 402 676033
SGTC_433 pimozide 108 µM 1.43211115426162 0.0791134341836292 no 313 0.076056006368994 359 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2070 5230947 200 µM 1.43204443035039 0.0791232055863724 no 314 0.0760655531253019 465 2835538
SGTC_1079 idarubicin 2.36 µM 1.43176441762581 0.0791642220973285 no 315 0.0761056268701368 428 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1715 st032160 10.2275 µM 1.43050276563468 0.0793492297084439 no 316 0.0762863863131233 454 5289825
SGTC_2968 9090663 33.37 µM 1.4300278131379 0.0794189610816083 no 317 0.0763545183042572 463 25236811
SGTC_2429 5902844 64.44 µM 1.42805614931234 0.0797089319495076 no 318 0.0766378488409667 485 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1778 st046819 58.9 µM 1.42483076926054 0.0801850114470606 no 319 0.0771030628396054 536 671715
SGTC_594 1487-1584 10.8 µM 1.4218933115994 0.0806204595907309 no 320 0.0775286125765235 466 5013332
SGTC_710 3448-4187 58 µM 1.42045121327328 0.0808348885136118 no 321 0.0777381810981827 571 3946412
SGTC_1148 3909-7663 27.7 µM 1.41949232435479 0.0809777060798588 no 322 0.0778777665304129 473 4084526
SGTC_1466 k213-0079 57.5 µM 1.41562636951003 0.0815554363113545 no 323 0.078442463259295 495 3657981
SGTC_950 1165-0508 94.1 µM 1.40828648579633 0.0826608560607799 no 324 0.0795231278569751 464 6148369
SGTC_525 k781-2675 26.7 µM 1.40442006400941 0.0832476726451396 no 325 0.0800968998337599 504 3651118 YDL195W SEC31
SGTC_1628 st004252 77.7 µM 1.40246497473847 0.0835455911769021 no 326 0.0803882212855704 510 692968
SGTC_2388 9080168 200 µM 1.40020308286311 0.0838912594038301 no 327 0.0807262564737737 426 15943073
SGTC_1072 oxiconazole 14.9 nM 1.39923178104853 0.0840400254997423 no 328 0.0808717445755358 518 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1463 k081-0032 34.1 µM 1.39731364234302 0.0843343922683891 no 329 0.0811596375790993 387 977755
SGTC_2308 7584454 197.62 µM 1.39671407838377 0.0844265627721403 no 330 0.0812497844531849 547 893577
SGTC_3161 9100388 49.47 µM 1.39212959537813 0.0851338317184279 no 331 0.0819415788415481 462 25236368
SGTC_1636 st007707 68.9 µM 1.3916500734442 0.0852080654758184 no 332 0.0820141939101523 539 403051
SGTC_1187 1391-0724 117 µM 1.38956488773349 0.0855314326565561 no 333 0.0823305221010991 516 6997986
SGTC_177 1327-0068 8.361 µM 1.38915193573187 0.0855955814545728 no 334 0.0823932768617854 504 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_3089 9117425 49.47 µM 1.38547831208696 0.0861678360972546 no 335 0.0829531298248663 468 9401657
SGTC_298 1391-0729 10 µM 1.38219182992444 0.0866822053015439 no 336 0.0834564040229044 454 3237558
SGTC_558 k064-0027 21.3 µM 1.3819954725853 0.0867130097938241 no 337 0.0834865456204507 498 5088526
SGTC_2689 tacrolimus 100 µM 1.38172755065043 0.0867550545186593 no 338 0.0835276858515325 492 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_76 0433-0009 400.328 µM 1.38042464626024 0.0869597352151164 no 339 0.083727968003834 403 2841569
SGTC_61 0978-8327 98.565 µM 1.37352060484807 0.0880503541317702 no 340 0.0847952800620082 514 6150059 YHR072W ERG7
SGTC_2571 chrysanthemic acid 100 µM 1.37095756342282 0.0884578183820606 no 341 0.0851940926273681 464 2743 An insecticide.
SGTC_2821 7996764 71.43 µM 1.36684382460027 0.0891147420856719 no 342 0.0858371314573031 522 2987135
SGTC_252 miconazole 1.30953 nM 1.35398317884374 0.0911918749827358 no 343 0.0878708721712272 489 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.35272751696755 0.0913965858791587 no 344 0.0880713481186365 489 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_32 0928-0142 34.1 µM 1.34858076940795 0.0920750512348599 no 345 0.088735830481268 459 2244242
SGTC_2178 5812956 200 µM 1.34588034352739 0.0925188787979525 no 346 0.0891705545049307 471 5403383
SGTC_1264 0783-0040 158 µM 1.34320423190456 0.0929602696859509 no 347 0.0896029258694518 482 2855798
SGTC_2144 5628481 200 µM 1.34235397255992 0.0931008346098358 no 348 0.0897406255445954 461 2818399
SGTC_1278 0874-0585 172 µM 1.33776418963029 0.0938623313451684 no 349 0.0904866594171771 522 766306
SGTC_2465 5809242 33.21 µM 1.33758477835168 0.0938921907869992 no 350 0.0905159145714165 474 2731748
SGTC_1945 st075991 56.6 µM 1.33727023320356 0.0939445574950383 no 351 0.0905672218653749 505 1084980
SGTC_250 brefeldin a 552.239 µM 1.33634598048307 0.0940985554206647 no 352 0.0907181070346023 431 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_931 2812-0076 566 µM 1.33401716018654 0.0944874065080291 no 353 0.0910991163553099 545 3450959
SGTC_843 0310-0051 143 µM 1.32915949621611 0.0953023178878574 no 354 0.0918976774095145 522 2065037
SGTC_3254 9136651 49.47 µM 1.32898357759807 0.095331926409322 no 355 0.0919266939892981 550 16454030
SGTC_2516 gossypol 71.55 µM 1.32884697716443 0.0953549220339617 no 356 0.0919492299814376 561 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2958 9077254 16.72 µM 1.32764395952552 0.0955576170969906 no 357 0.0921478774778339 480 16457351
SGTC_752 1896-0090 130 µM 1.32684831576866 0.0956918482950312 no 358 0.0922794320648629 529 772567
SGTC_526 4469-0568 170 µM 1.32204008111682 0.0965059877596983 no 359 0.0930774022664288 521 2901964
SGTC_2760 etidronate 98.04 µM 1.31752603575216 0.0972749353771177 no 360 0.0938311799258028 520 3305 A chelator and antioxidant.
SGTC_2062 5245942 200 µM 1.31289538910833 0.09806840680938 no 361 0.0946091004080105 566 1376160
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.31168447539295 0.0982766795672269 no 362 0.0948133085072194 518 521171
SGTC_3312 9133330 71.43 µM 1.31155036809335 0.0982997654468778 no 363 0.0948359442808682 560 17617324
SGTC_660 4031-1742 102 µM 1.30933980881453 0.0986808743145485 no 364 0.0952096352902234 574 6738706
SGTC_1222 0366-0074 1.18 µM 1.30802730733431 0.0989076656532043 no 365 0.0954320236701788 563 286520
SGTC_1860 st056228 74.6 µM 1.3070584917842 0.0990753148629405 no 366 0.0955964235120003 523 688679
SGTC_944 3370-0224 231 µM 1.30686300530806 0.0991091681114026 no 367 0.0956296211746082 535 4580514
SGTC_1147 3809-1045 12.3 µM 1.30460849137379 0.0995002037171107 no 368 0.0960130976865392 534 325925
SGTC_923 1900-2434 73.3 µM 1.30138955300657 0.100060467112699 no 369 0.0965625738677994 534 5910570
SGTC_3038 9091290 49.47 µM 1.29726228218991 0.100782193335892 no 370 0.0972704787117949 554 25236843
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.29502995590641 0.101174133370864 no 371 0.0976549479281353 482 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2762 leflunomide 42.06 µM 1.28913693136497 0.10221413352874 no 372 0.0986752431240831 595 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_3248 9135562 49.47 µM 1.28375460521212 0.103170780899828 no 373 0.0996139157996373 597 17650701
SGTC_2244 6635614 200 µM 1.283514761322 0.103213561244436 no 374 0.0996558956908158 409 836499
SGTC_1115 galangin 695.678 nM 1.28328639746835 0.103254305893736 no 375 0.0996958782424928 605 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_516 3992-2719 87.3 µM 1.27933925280827 0.103960401244672 no 376 0.100388807790092 514 5350887 YDR037W KRS1
SGTC_2086 5274770 176.623 µM 1.27394852881924 0.104930382481272 no 377 0.101340829075428 545 689278
SGTC_2063 5246145 200 µM 1.27107334659395 0.105450400378852 no 378 0.101851278198033 590 711240
SGTC_1893 st059353 36.1 µM 1.27047261695628 0.105559285954032 no 379 0.10195816544045 572 3112488
SGTC_2078 5212016 200 µM 1.27026088851317 0.105597682279026 no 380 0.101995857526359 510 1899708
SGTC_3179 9107801 49.47 µM 1.26761953469957 0.10607753303838 no 381 0.102466926199741 560 4818259
SGTC_707 0865-0008 204 µM 1.26652310949893 0.106277180963757 no 382 0.102662930574375 588 723043
SGTC_512 prima-1 270 µM 1.25860204311965 0.10772759325456 no 383 0.104087054350876 605 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2446 5162541 200 µM 1.2569938812144 0.108023794158134 no 384 0.104377925622783 541 1549321
SGTC_2484 5809818 12.04 µM 1.2555526173548 0.108289752652276 no 385 0.10463910983866 572 2870548
SGTC_1709 st033179 39.1045 µM 1.25548431000812 0.108302369191383 no 386 0.10465150015821 599 573381
SGTC_1979 st071809 45.3 µM 1.25121777220639 0.109092507218178 no 387 0.105427517945541 585 4976333
SGTC_2449 5812982 45.77 µM 1.2484924123178 0.10959939150857 no 388 0.105925392692135 528 776185
SGTC_3174 9107204 49.47 µM 1.24835004694187 0.109625916161318 no 389 0.105951446931821 577 3938802
SGTC_2000 st075254 36.4 µM 1.24755604131931 0.109773935007376 no 390 0.10609684257842 541 17234175
SGTC_2727 riluzole 51.77 µM 1.24385164223323 0.110466406534281 no 391 0.10677708489742 534 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_790 1575-0012 79.1 µM 1.24242330463952 0.110734243646645 no 392 0.107040210803864 599 378741 YLR208W SEC13
SGTC_2352 9027995 87.8 µM 1.24223717216904 0.110769180830745 no 393 0.107074534222629 529 2997347
SGTC_139 0099-0334 718.624 µM 1.24101120555634 0.110999492894484 no 394 0.107300804696548 673 97690
SGTC_2785 7756463 72.73 µM 1.23976003853198 0.111234892575012 no 395 0.107532081498607 571 2201551
SGTC_2296 7971656 126.45 µM 1.23855627618979 0.111461710497752 no 396 0.10775493447288 586 666570
SGTC_2339 9000433 200 µM 1.237448823854 0.111670673444853 no 397 0.107960251200664 533 2988954
SGTC_952 1185-0122 232 µM 1.23451701918792 0.112225222408996 no 398 0.108505154422359 581 678600
SGTC_93 0109-0045 59.227 µM 1.23430563064887 0.112265282350436 no 399 0.1085445192873 704 88733
SGTC_601 0986-0029 62.9 µM 1.23370260246768 0.11237961751844 no 400 0.108656871908102 626 24747981
SGTC_2291 7917025 104.35 µM 1.23097062643917 0.112898647074777 no 401 0.109166925248233 623 2964612
SGTC_703 3875-0075 71.8 µM 1.22749257650129 0.113561891063245 no 402 0.109818755131315 627 2850814
SGTC_1444 4112-3581 28 µM 1.22009645067947 0.114981513601789 no 403 0.111214156957028 608 2877249
SGTC_497 capsazepine 133 µM 1.21711251296133 0.11555781315294 no 404 0.111780705232744 584 2733484 A calcium channel blocker.
SGTC_2045 5106652 78.05 µM 1.21573448756317 0.115824648145531 no 405 0.112043041021943 580 673349
SGTC_2826 7992541 19.48 µM 1.21356594329191 0.116245441400629 no 406 0.112456759346047 594 2985066
SGTC_2134 5324836 1.464 µM 1.21171535893665 0.116605393345619 no 407 0.11281067888474 535 699272
SGTC_2497 7-hydroxyflavone 100 µM 1.2110339087233 0.116738139213966 no 408 0.112941204620741 541 5281894
SGTC_3136 9095672 49.47 µM 1.21048029337388 0.116846061820218 no 409 0.113047324057785 536 17217380
SGTC_1395 3486-0190 4.35 µM 1.20922994850853 0.117090066112144 no 410 0.113287257479346 652 6748079
SGTC_169 k015-0017 16.025 µM 1.20897950122723 0.117138984165575 no 411 0.113335360395136 547 1840002
SGTC_1941 st076221 61.8 µM 1.20766535049125 0.117395905025262 no 412 0.113588005527519 665 2828568
SGTC_2719 novobiocin 32.65 µM 1.20589177780802 0.117743276722248 no 413 0.113929610675315 529 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.19775219716513 0.119346822304846 no 414 0.115506751036662 713 368090
SGTC_771 0250-0039 27.3 µM 1.1965140201092 0.119592094573636 no 415 0.115748015361324 629 3005115
SGTC_1233 0325-0408 14.2 µM 1.195539041802 0.119785479480294 no 416 0.115938245952526 611 12874
SGTC_1557 sumaresinolic acid 42.3 µM 1.19328007446424 0.12023438792099 no 417 0.11637985170392 586 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1602 st001878 87.6 µM 1.19032143148863 0.120824128884182 no 418 0.116960040227126 617 595405 YLR310C CDC25
SGTC_1117 retinoic acid 1.10837 µM 1.19000188521887 0.120887945069762 no 419 0.117022825539372 687 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2216 7189485 200 µM 1.1895326746343 0.120981693508082 no 420 0.117115060575123 643 731273
SGTC_222 nsc-310342 10.666 µM 1.18793482160829 0.121301328764283 no 421 0.117429544731335 506 432556
SGTC_1162 k048-0130 20.1 µM 1.18508850300037 0.121872177784702 no 422 0.117991228141369 634 6797406
SGTC_3208 9114115 49.47 µM 1.18344558697511 0.122202533748253 no 423 0.118316299687895 557 650895
SGTC_1025 k007-0731 70 µM 1.18263613838689 0.122365527860238 no 424 0.118476691860797 609 6256118
SGTC_256 clotrimazole 625 nM 1.17697223636155 0.123510305561532 no 425 0.119603293935303 629 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1134 3477-0009 42.5 µM 1.17222713484518 0.124475134999697 no 426 0.120552938448086 691 3973534
SGTC_112 phenothiazine 287.218 µM 1.17162892632356 0.124597142771534 no 427 0.120673034662638 666 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_327 1273-0057 3.96 µM 1.1712812415175 0.124668093316183 no 428 0.120742874480354 607 3108138
SGTC_1257 0669-0121 16 µM 1.16943528593444 0.125045262494037 no 429 0.121114150078934 699 4307855
SGTC_1801 st050089 28.441 µM 1.16886711529845 0.125161512449853 no 430 0.12122858725547 747 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1664 st014217 9.02 µM 1.16525023958328 0.125903308876328 no 431 0.121958857421326 702 3982782
SGTC_2580 diallyl disulphide 81.36 µM 1.16455273410838 0.126046714391274 no 432 0.122100042846699 611 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2665 lovastatin 100 µM 1.16410114341656 0.126139621105867 no 433 0.122191512666547 636 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_543 3844-1095 191 µM 1.15835349083935 0.127326269136056 no 434 0.123359905349914 701 4230703
SGTC_3014 9081533 49.47 µM 1.15678399067501 0.127651650124948 no 435 0.123680312101678 686 21367265
SGTC_2925 9010536 32.5 µM 1.15163778363431 0.128722589244076 no 436 0.124734974162097 723 2994177
SGTC_2034 5197015 53.07 µM 1.14957210847851 0.129154209988415 no 437 0.125160075701807 667 780676
SGTC_2517 totarol 10 µM 1.14860639428996 0.12935633879278 no 438 0.125359159601982 590 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2607 solasodine 47.35 µM 1.14798219189559 0.129487104056815 no 439 0.125487957725671 674 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1809 st050081 57.6 µM 1.14787868395242 0.129508796968745 no 440 0.12550932451203 673 5036894
SGTC_1167 k781-0610 148 µM 1.14473825527534 0.13016815671089 no 441 0.126158799699603 709 4525169
SGTC_2792 7535235 81.82 µM 1.14421877629657 0.13027744925872 no 442 0.126266459071513 611 1281891
SGTC_1919 st067113 52.3 µM 1.13838670901791 0.131508808774832 no 443 0.127479520719197 686 1268243
SGTC_3146 9095609 49.47 µM 1.13812099199266 0.131565101932326 no 444 0.127534981852871 686 17173999
SGTC_3249 9135183 49.47 µM 1.13665579975294 0.131875807144788 no 445 0.127841101811264 700 4902779
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.13665349263041 0.131876296786554 no 446 0.127841584236492 715 676296 Flavone; oxidizing agent.
SGTC_345 1362-0200 395 µM 1.13639010074322 0.131932204822753 no 447 0.127896668471487 632 1419823
SGTC_3300 9124615 50.48 µM 1.13576814175057 0.132064287832264 no 448 0.128026806773808 664 24824903
SGTC_2106 5357045 167.29 µM 1.13384222929981 0.13247386458479 no 449 0.128430366800442 691 668842
SGTC_1578 josamycin 24.2 µM 1.13125151319728 0.133026202058342 no 450 0.128974622918871 615 5282165 A P450 substrate.
SGTC_195 4234-0266 16.654 µM 1.1311819996686 0.133041044062756 no 451 0.128989248281424 729 2303354
SGTC_1116 jasmonic acid 1.58368 µM 1.12829864089442 0.133657681467019 no 452 0.129596908637809 692 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1070 indatraline 8.81 µM 1.12660836093419 0.134020078341623 no 453 0.129954051277113 676 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_3305 9127027 53.8275 µM 1.1256917826329 0.134216875254324 no 454 0.130148001585293 681 41905295
SGTC_1249 0481-0015 10.2 µM 1.1231479816073 0.13476408977487 no 455 0.130687325427333 617 4227577
SGTC_1152 3909-8331 15.9 µM 1.12273755466927 0.134852522753621 no 456 0.130774486617812 645 16001939
SGTC_2321 7390090 138.78 µM 1.12168270909928 0.135079988542732 no 457 0.130998685459637 609 649046
SGTC_674 0498-0004 451 µM 1.12108868525184 0.135208198960819 no 458 0.131125057214126 659 4231473
SGTC_1280 0880-0253 10.1 µM 1.1196701748081 0.135514698854745 no 459 0.131427169595325 707 6836607
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.11889325440949 0.13568277095815 no 460 0.131592840545429 650 6708760
SGTC_1632 st005650 90 µM 1.11599842573011 0.136310269531858 no 461 0.132211404235158 667 2759605
SGTC_2556 citropten 84.59 µM 1.11485268289868 0.136559174480312 no 462 0.132456778059974 733 2775 A potential DNA crosslinker.
SGTC_2328 6201408 200 µM 1.1127774244228 0.137010801430246 no 463 0.132902016747435 669 2890418
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.10956932341229 0.137710968989809 no 464 0.13359232820916 744 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2747 doxorubicin 7.63 µM 1.10775434115333 0.138108168239161 no 465 0.133983961900107 506 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1837 st055472 66.5 µM 1.10654102771008 0.138374130733058 no 466 0.134246208101365 711 676091
SGTC_1032 k061-1018 98.7 µM 1.10444475002636 0.13883446416798 no 467 0.134700128914832 790 4005393
SGTC_97 0535-0701 19.132 µM 1.10421023109274 0.138886028289483 no 468 0.134750976274086 658 2832013 YGL099W LSG1
SGTC_111 0083-0039 52.457 µM 1.10383040530173 0.138969568965344 no 469 0.134833356360628 557 759313
SGTC_1695 st026914 34.495 µM 1.10376808303255 0.13898327968575 no 470 0.13484687668272 704 3289191
SGTC_371 0195-0006 7.36 µM 1.10336872876986 0.139071158335194 no 471 0.134933535498784 624 3928593
SGTC_2203 7227154 166.4 µM 1.10263075324407 0.13923365073284 no 472 0.13509377473399 667 896304
SGTC_1591 genipin 88.4 µM 1.10211296918447 0.139347736992433 no 473 0.135206280884459 676 442424 A DNA cross-linking agent.
SGTC_2299 7976368 114.88 µM 1.10202039522554 0.139368141030889 no 474 0.135226402484399 697 2979718
SGTC_1990 st072050 59.8 µM 1.10142959047323 0.139498406985416 no 475 0.13535486640411 717 17233948
SGTC_1046 2001-0062 216 µM 1.10073354945737 0.139651982603232 no 476 0.135506320070937 695 739778
SGTC_1029 k015-0030 64.7 µM 1.09909126862715 0.140014793597056 no 477 0.135864129005412 694 2208316
SGTC_2192 5915882 198.485 µM 1.09841629288696 0.140164094092388 no 478 0.136011375539571 651 2876149
SGTC_1129 3453-1384 223 µM 1.09824381065414 0.140202263447298 no 479 0.136049020204737 744 1084452
SGTC_191 3914-0123 66.505 µM 1.09773091866978 0.140315805288597 no 480 0.136161002256773 563 3144412
SGTC_508 roscovitine 141 µM 1.09743827467235 0.140380617541507 no 481 0.136224924815994 711 160355 A CDKinase inhibitor.
SGTC_3020 9089140 49.47 µM 1.09500493411558 0.140920319914052 no 482 0.136757237421225 682 17217859
SGTC_2812 7970281 58.44 µM 1.09493971245056 0.140934805085169 no 483 0.136771524720382 712 2233435
SGTC_2768 sulfasalazine 50.2 µM 1.09465457365839 0.140998143819071 no 484 0.136833998511523 708 5384001 An antioxidant and salicylic acid derivative.
SGTC_2827 7993847 71.43 µM 1.09382226578015 0.141183137275429 no 485 0.137016468375634 651 2985692
SGTC_2806 7952793 58.44 µM 1.09220896184836 0.141542187795835 no 486 0.137370632136919 714 2972490
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.09160908514312 0.141675851631997 no 487 0.137502480560255 755 6708561
SGTC_1699 st031318 29.054 µM 1.08736113367142 0.14262482148514 no 488 0.138438620379285 728 5340658
SGTC_1961 st076550 68.7 µM 1.08611653759697 0.142903669899728 no 489 0.138713718310588 653 1579337
SGTC_2301 7769476 200 µM 1.07992028790246 0.144297403987652 no 490 0.140088839030145 669 977820
SGTC_29 0299-0004 12.984 µM 1.0789449942994 0.144517610381666 no 491 0.140306124630096 612 16871 A napthoquinone isolated from Swertia calycina.
SGTC_597 k018-0003 82.8 µM 1.07845002533028 0.144629453381098 no 492 0.140416486244921 805 6786234
SGTC_998 3996-0085 177 µM 1.07690990673178 0.144977830878376 no 493 0.140760258411885 789 715391
SGTC_1212 0520-0165 585 µM 1.0747125349127 0.145475857413216 no 494 0.141251724973802 704 5403258
SGTC_1071 trifluoperazine 6.31 µM 1.07463035266372 0.14549450602318 no 495 0.14127012848441 754 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_408 cantharidin 100 µM 1.0731908965128 0.145821404853928 no 496 0.141592737177886 752 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_348 k064-0012 10.7 µM 1.07306709994953 0.145849541945769 no 497 0.141620505562878 694 5066323
SGTC_2050 5263056 171 µM 1.07186553253441 0.146122829672521 no 498 0.141890216731029 804 763468 YGL055W OLE1
SGTC_2539 epi(13)torulosol 80 µM 1.07139444296004 0.146230069359821 no 499 0.141996055226853 686 6708597
SGTC_141 0443-0274 32.331 µM 1.07086916288298 0.146349707383064 no 500 0.142114131570974 840 1627241
SGTC_2997 9067075 71.4286 µM 1.06920645301421 0.146728840088212 no 501 0.142488325814271 756 27209819
SGTC_2905 7799065 20.05 µM 1.06819390992851 0.146960043703973 no 502 0.142716525665563 700 1296806
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.06782192563283 0.147045043759738 no 503 0.142800422899878 726 6312947
SGTC_332 4112-0506 40.9 µM 1.06599444679069 0.14746310949019 no 504 0.14321307611244 737 2790355
SGTC_780 0109-0199 192 µM 1.0646676197731 0.147767141445181 no 505 0.143513184001827 783 610414
SGTC_1168 k815-0004 80.5 µM 1.06267180844465 0.14822525591761 no 506 0.143965404905698 732 642433
SGTC_628 1636-0253 16 µM 1.06249393851255 0.148266129886645 no 507 0.144005754157429 755 4456143
SGTC_2502 avocadyne acetate 18.59 µM 1.06126012596671 0.148549863801628 no 508 0.144285850701577 787 3952079
SGTC_447 ml7 120 µM 1.06092382329972 0.148627264626087 no 509 0.144362260804694 762 4216 Selective myosin light chain kinase inhibitor.
SGTC_1177 0983-0204 23.6 µM 1.06037965044395 0.148752564347135 no 510 0.144485958093399 785 766818
SGTC_1468 k284-1086 134 µM 1.06033969004715 0.148761768298256 no 511 0.144495044404763 792 15996457
SGTC_1474 0330-0125 5.35 µM 1.05893799125873 0.149084857962895 no 512 0.144814010381417 749 X1474
SGTC_304 1310-0298 97 µM 1.05739601113032 0.149440823307649 no 513 0.145165445617655 765 1550234
SGTC_2831 7999036 19.48 µM 1.05618874228018 0.149719916369624 no 514 0.145440996512801 790 2988270
SGTC_1169 aniline yellow 25.8 µM 1.05611124432841 0.149737844000656 no 515 0.145458696900971 715 6051 A DNA damaging agent.
SGTC_172 1112-0046 2.638 µM 1.05562967558573 0.149849277580321 no 516 0.145568718779599 668 2802135 YIL048W NEO1
SGTC_841 0251-0215 91.2 µM 1.05527630117471 0.149931082547365 no 517 0.145649488254747 788 3888614
SGTC_1348 1493-0373 93.8 µM 1.05520475520991 0.149947648817959 no 518 0.145665844916943 750 3010129
SGTC_1452 4194-0072 190 µM 1.05420262030563 0.150179818673253 no 519 0.145895080321856 818 1343545
SGTC_521 r062-0005 13.8 µM 1.04887043933627 0.15141918060876 no 520 0.147118876191793 732 2832033
SGTC_3338 9144300 39.5675 µM 1.0486505845527 0.151470427160017 no 521 0.147169482660846 770 4901274
SGTC_620 0109-0052 432 µM 1.04798986750539 0.151624504895215 no 522 0.147321637624773 781 493037
SGTC_2300 7976697 71.57 µM 1.04671234257279 0.151922716206977 no 523 0.147616134721101 649 2236109
SGTC_721 1187-1332 279 µM 1.04505964874223 0.152309080493604 no 524 0.147997701004469 669 25730
SGTC_2458 5808907 16.39 µM 1.04470088733227 0.15239303728672 no 525 0.148080617303319 828 2731747
SGTC_2351 9026858 72.31 µM 1.0421758070607 0.152984821464626 no 526 0.148665088692269 704 1409300
SGTC_412 gemfibrozil 100 µM 1.04082792263575 0.153301337913182 no 527 0.148977709179997 711 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2967 9089538 49.85 µM 1.03760605718801 0.154059668107768 no 528 0.149726748386825 781 728216
SGTC_1732 st034308 51.822 µM 1.03331800706069 0.155072789216706 no 529 0.150727551535127 728 830119
SGTC_1627 st003713 25.6 µM 1.03308996798173 0.155126790046264 no 530 0.15078089882835 820 16195070 YER133W GLC7
SGTC_1874 staurosporine 7.6 µM 1.03296517708997 0.155156346428092 no 531 0.150810097638337 802 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.0329136044717 0.155168562347473 no 532 0.150822165796801 828 66535 A nucleotide analog.
SGTC_2645 abamectin 100 µM 1.03243096480781 0.15528291516765 no 533 0.150935136190469 738 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2858 9025781 8.96 µM 1.03178076072972 0.155437057291285 no 534 0.151087417037204 865 4894980 YPL153C RAD53
SGTC_1563 conessine 56.1 µM 1.03045963183992 0.155750564612579 no 535 0.151397146405729 878 441082 An anti-amoebic, histamine inhibitor.
SGTC_1600 coumarin 106 71.1 µM 1.02902012847639 0.156092636856741 no 536 0.151735108184408 798 100336 A hepatotoxic, DNA x-linker.
SGTC_1819 st053448 58.6 µM 1.02752435021834 0.156448605919455 no 537 0.152086812741723 771 2857616
SGTC_457 grayanotoxin iii 135 µM 1.02694820964622 0.156585859795091 no 538 0.152222425839197 812 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2929 9013348 24.6 µM 1.02689204688404 0.156599243680068 no 539 0.152235649833564 725 2995952
SGTC_817 1391-0715 46 µM 1.02282056391511 0.157571505932053 no 540 0.153196346635098 742 1353946
SGTC_1724 st037281 8.293 µM 1.02232940306111 0.15768906172087 no 541 0.153312510677162 755 574124 YDL195W SEC31
SGTC_3156 9099931 49.47 µM 1.02128290006942 0.157939726728145 no 542 0.153560212814146 822 18111053
SGTC_3273 9137859 49.47 µM 1.02066474811395 0.158087913234478 no 543 0.153706650795388 782 2377234
SGTC_2471 5466956 24.79 µM 1.02009419738864 0.158224769500635 no 544 0.153841894235185 766 724419
SGTC_3284 9108171 64.8615 µM 1.01918433131844 0.158443177112197 no 545 0.154057731941697 742 8687505
SGTC_2842 9000675 19.48 µM 1.01867450577566 0.158565643927004 no 546 0.154178759888161 714 2989072
SGTC_1910 st062352 60.4 µM 1.0174353285426 0.158863569372339 no 547 0.154473191417656 764 2245730
SGTC_2421 5690543 90.72 µM 1.01489376504685 0.159475764251408 no 548 0.155078235308733 787 3397993
SGTC_3063 1327-0034 4 µM 1.01468501890452 0.159526114170476 no 549 0.155127998799374 764 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3267 9137951 49.47 µM 1.01138393158172 0.160323725133779 no 550 0.155916354385606 771 16643986
SGTC_955 1216-0110 33 µM 1.00759683753808 0.161241969877926 no 551 0.156824023881294 787 3619719
SGTC_3323 9138564 53.9225 µM 1.00714474056401 0.161351817184433 no 552 0.15693261180644 863 43912313 YNL103W MET4
SGTC_3132 9126706 49.47 µM 1.00591165662237 0.161651671190608 no 553 0.157229034229047 764 850858
SGTC_2906 7926292 26.41 µM 1.00500478275141 0.161872431024029 no 554 0.157447273433652 774 2966319
SGTC_1330 1469-0054 61.8 µM 1.00265593499594 0.162445122581308 no 555 0.158013448844832 861 7102664
SGTC_423 5-fluorouracil 457 µM 1.00165931932351 0.162688513452802 no 556 0.158254080346297 765 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1132 3456-3614 2.5 µM 1.00163107972561 0.162695413507714 no 557 0.158260902260368 895 3125502
SGTC_840 0245-0196 390 µM 1.00153797646831 0.162718163678123 no 558 0.158283394826355 853 3827528
SGTC_1654 st012436 41.8 µM 0.997744527295988 0.163646868402432 no 559 0.159201627766805 760 4323132
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.993772043266949 0.164623085494535 no 560 0.160166929817146 797 616764
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.992322922133909 0.16498013682003 no 561 0.160520012532515 886 688761
SGTC_3293 9120939 62.045 µM 0.9916049502073 0.165157224724097 no 562 0.16069513678041 784 934087
SGTC_337 1315-0038 354 µM 0.99029916656524 0.165479611745816 no 563 0.161013956916174 807 1626437
SGTC_1480 1070-0044 41.2 µM 0.989513961152013 0.165673668230671 no 564 0.16120587129331 820 3124987
SGTC_2526 patulin 37.61 µM 0.988246392340671 0.165987246888138 no 565 0.161515996307062 845 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1957 st077035 62.4 µM 0.986735457114138 0.166361531699496 no 566 0.161886171502452 839 705593
SGTC_2529 gangaleoidin 93.61 µM 0.986649733910875 0.16638278314519 no 567 0.161907190020619 832 4565183
SGTC_1951 sophoraflavanone G 9.2 µM 0.986409371161012 0.166442380279328 no 568 0.161966134173112 815 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.984414591947986 0.166937510788651 no 569 0.162455853158966 867 6708784 An antioxidant flavonoid
SGTC_1959 st077091 55.8 µM 0.984122227538218 0.167010159231652 no 570 0.162527709604617 836 821356 YKL052C ASK1
SGTC_2242 6630449 61.2675 µM 0.982172405849072 0.167495183790371 no 571 0.16300745970506 701 691249 YDR170C SEC7
SGTC_1915 st067105 30.6 µM 0.980601473225882 0.167886617884859 no 572 0.163394653778831 809 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_562 3772-2733 112 µM 0.979839294233109 0.168076744355206 no 573 0.163582726159495 894 2876874 YIL048W NEO1
SGTC_3304 9125678 46.087 µM 0.979408816567409 0.168184188731508 no 574 0.163689011276282 801 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2593 nobiletin 86.24 µM 0.977602511324079 0.168635512163862 no 575 0.164135477401365 753 72344 An anti-infammatory.
SGTC_1053 3366-3204 134 µM 0.976523017411333 0.168905605809261 no 576 0.164402673610133 805 3632071 YPR165W RHO1
SGTC_622 1348-1566 26.3 µM 0.975469325394514 0.169169511589852 no 577 0.164663755126955 880 7340407
SGTC_2893 9048488 25.97 µM 0.972278808399549 0.169970216181009 no 578 0.165455931726253 797 6467338
SGTC_1570 verbenone 133 µM 0.971977910222182 0.170045855925536 no 579 0.165530769040895 855 29025 A natural terpanoid with antifungal properties.
SGTC_2368 9071271 200 µM 0.971551652881178 0.170153045364007 no 580 0.165636822290399 795 27209959
SGTC_1681 tripelennamine 100 µM 0.970044283380652 0.170532445476344 no 581 0.166012209657565 780 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_377 3970-0964 33.1 µM 0.968470688238695 0.170929091812015 no 582 0.166404675537563 915 16481235
SGTC_2250 alverine citrate 130 µM 0.967950773129207 0.171060273201778 no 583 0.166534477640286 881 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_343 4130-2827 29.8 µM 0.96583081259161 0.171595833387965 no 584 0.167064423741257 843 1118244
SGTC_3341 9147222 25.867 µM 0.965307937080163 0.171728090611512 no 585 0.167195298753811 791 1939759
SGTC_646 4092-0839 27.3 µM 0.96416413475428 0.172017633299405 no 586 0.167481821239877 880 877796
SGTC_2507 purpurin 79.67 µM 0.959486097133845 0.173205075439702 no 587 0.168656960114518 839 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2472 5377652 49.4 µM 0.959482485353531 0.173205994242145 no 588 0.168657869448556 849 1610903
SGTC_1967 st070177 51.4 µM 0.958789522265925 0.173382334862624 no 589 0.16883239432003 826 5729214
SGTC_1663 st014140 55.4 µM 0.95865916524358 0.17341552001496 no 590 0.16886523809719 980 4207120
SGTC_580 1123-0028 41 µM 0.957311169807203 0.173758917966516 no 591 0.16920510958732 951 1677248 YPR107C YTH1
SGTC_211 3455-0679 143.504 µM 0.956835585832722 0.17388017476616 no 592 0.169325123804182 870 748649
SGTC_2540 epiandrosterone 100 µM 0.956714283308595 0.17391111115582 no 593 0.169355743392759 1020 441302 A steroid.
SGTC_1235 benzylparaben 21.5 µM 0.955513668020984 0.174217498822955 no 594 0.169658998363259 808 7180
SGTC_3294 9122953 26.2835 µM 0.954830002462582 0.174392118131502 no 595 0.169831836182887 858 16459826
SGTC_1303 1160-0052 261 µM 0.954799265582833 0.174399971441673 no 596 0.169839609439495 864 3562476
SGTC_1100 amiodarone 5.07 µM 0.953928401096833 0.174622571729784 no 597 0.170059943021797 901 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1063 disulfiram 1.84 µM 0.95182351717649 0.175161342373592 no 598 0.170593246560423 835 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1158 4092-0494 91.8 µM 0.947765509363307 0.176203010933325 no 599 0.17162442138403 891 1148199
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.947659222822588 0.176230346695564 no 600 0.171651483119738 880 94937 An inhibitor of serotonin biosynthesis.
SGTC_2095 5432005 200 µM 0.945705106296955 0.176733402785502 no 601 0.172149508656908 816 783734
SGTC_3240 9133527 49.47 µM 0.945415268738475 0.176808094073871 no 602 0.17222345502354 830 17617455
SGTC_2771 fluoxetine 41.05 µM 0.941821885112628 0.177735767540362 no 603 0.173141919244602 827 3386 A selective serotonin reuptake inhibitor.
SGTC_1971 st069429 63.5 µM 0.941395789708647 0.177845972278153 no 604 0.173251035201203 876 1246522 YGL099W LSG1
SGTC_2353 9059630 146.67 µM 0.938824384493358 0.178511951614088 no 605 0.173910458558257 897 4779114
SGTC_1546 5-methoxyflavanone 78.7 µM 0.938573788557956 0.178576938433929 no 606 0.173974807809728 910 147795
SGTC_1936 st074407 74.3 µM 0.937802603436005 0.178777022646405 no 607 0.174172931467372 899 809813
SGTC_2726 cimetidine 79.27 µM 0.937613878282672 0.178826008930639 no 608 0.174221438308181 838 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_509 pifithrin 175 µM 0.937121213578312 0.178953926838368 no 609 0.174348105275458 933 4817 A p53 inhibitor.
SGTC_529 4076-0302 30.3 µM 0.935861699177745 0.179281215103353 no 610 0.174672199686036 849 5816522
SGTC_1271 0832-2808 169 µM 0.932871268106868 0.180059793478238 no 611 0.175443219354422 918 3663794
SGTC_2868 9035608 32.47 µM 0.932778610084764 0.180083951461137 no 612 0.175467143681659 865 6462614
SGTC_711 k292-0785 179 µM 0.93210410608768 0.180259870793614 no 613 0.175641363116215 907 4146315
SGTC_925 2064-1272 59.6 µM 0.931885469207207 0.180316917246379 no 614 0.175697858933106 812 6815817
SGTC_1204 4049-0315 18.3 µM 0.929762400636016 0.180871454526183 no 615 0.176247058894267 853 588402
SGTC_3051 9093778 49.47 µM 0.928169525466698 0.181288208384333 no 616 0.17665981980508 827 17217378
SGTC_3315 9136395 68.55 µM 0.927678143510541 0.181416892977112 no 617 0.176787274616845 936 16876844
SGTC_900 1112-0045 141 µM 0.926994682052694 0.181595974990901 no 618 0.176964647698107 770 56211 YIL048W NEO1
SGTC_1218 1348-1416 30.7 µM 0.926465515893876 0.181734704183496 no 619 0.177102055012045 883 6787668
SGTC_2273 7815444 169.05 µM 0.924418752921494 0.182271919117351 no 620 0.177634167364539 866 2824616
SGTC_3122 9126309 49.47 µM 0.922231466382542 0.182847113056503 no 621 0.178203926578322 952 17591206
SGTC_1902 st060212 70.5 µM 0.921968730320692 0.182916281280037 no 622 0.17827244325233 909 688944
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.921365878448672 0.183075050524152 no 623 0.178429718536041 827 4620898
SGTC_228 caffeine 993.056 µM 0.920860119560318 0.183208315308003 no 624 0.178561731078567 854 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_532 1548-0774 215 µM 0.917281155933766 0.184153081304363 no 625 0.179497664659123 940 5932993
SGTC_483 fpl-64176 144 µM 0.915336936698281 0.184667580310605 no 626 0.180007386955992 846 3423
SGTC_1555 citronellol 128 µM 0.915098090255836 0.184730847862115 no 627 0.180070068732722 859 8842 A terpine precursor.
SGTC_3004 9076122 71.4286 µM 0.913381210472421 0.185186025149235 no 628 0.180521042070816 898 44782551
SGTC_3288 9119690 36.221 µM 0.913319598428042 0.185202372603445 no 629 0.180537238881689 820 17595618 YKL019W RAM2
SGTC_2438 5259590 200 µM 0.913099637404847 0.185260741924458 no 630 0.180595070515672 944 1201127
SGTC_297 0986-0032 24 µM 0.912476467689349 0.185426169571158 no 631 0.180758975901863 871 2847425
SGTC_2385 9074692 200 µM 0.911953623181476 0.185565035442434 no 632 0.180896565789543 898 17046906
SGTC_2635 hydroquinidine 100 µM 0.909616475574771 0.186186563243904 no 633 0.181512403343853 885 442912 An experimental heart treatment.
SGTC_1476 4112-3294 3.34 µM 0.908464373553971 0.18649342091277 no 634 0.181816464121381 926 704369
SGTC_484 loperamide 105 µM 0.908363040298851 0.186520425589592 no 635 0.181843223054772 828 3955 An opioid-receptor agonist.
SGTC_1822 st052468 42 µM 0.908079825353808 0.186595913437407 no 636 0.18191802429857 898 2873678
SGTC_3250 9135583 49.47 µM 0.907870853500519 0.18665162472755 no 637 0.181973229182569 880 7699353
SGTC_642 0335-0876 158 µM 0.90540841547058 0.187308878988279 no 638 0.182624529540838 913 6812350
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.905398676029336 0.187311481399652 no 639 0.182627108452376 982 91467 include heat shock
SGTC_438 sphingosine 6.67 µM 0.904970059049079 0.187426031432685 no 640 0.182740624679392 822 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1730 st033808 45.1 µM 0.904660828992066 0.1875087015952 no 641 0.182822549458078 978 1045166
SGTC_818 4072-2707 53.5 µM 0.904349922720357 0.187591842594394 no 642 0.182904941427047 902 882871
SGTC_1415 3966-0071 78.1 µM 0.90375726024936 0.187750392508576 no 643 0.18306206460396 896 2893185
SGTC_1333 1482-0047 286 µM 0.903266896132318 0.187881637973392 no 644 0.18319213068518 959 3811116
SGTC_2634 4'-methoxyflavone 100 µM 0.902177026449451 0.188173543322245 no 645 0.183481418299652 833 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_215 1287-0124 461.5 µM 0.902100209204801 0.188194128229015 no 646 0.183501818884685 899 5560863
SGTC_2952 9073731 13.78 µM 0.901483439088719 0.18835945600401 no 647 0.183665667608755 952 16457353
SGTC_555 4296-0685 37 µM 0.900451682321624 0.188636222882394 no 648 0.183939963772763 941 2908540 YHR072W ERG7
SGTC_3286 9117135 37.221 µM 0.897845862776265 0.189336344654148 no 649 0.18463386502634 863 3438150
SGTC_2860 9025725 38.96 µM 0.897683100820502 0.189380127932064 no 650 0.184677260696642 852 40546248
SGTC_885 0865-0106 16.8 µM 0.897159425048939 0.189521039992937 no 651 0.184816926400727 923 2793380
SGTC_2382 9035899 200 µM 0.895798281140431 0.189887601854663 no 652 0.185180254041563 909 6462679
SGTC_1883 5-benzylidenerhodanine 20 µM 0.895548102047926 0.189955023543011 no 653 0.185247082115757 945 1273210
SGTC_1603 st002045 67.8 µM 0.890874569626876 0.191217214818682 no 654 0.186498232243399 948 5887985
SGTC_781 4335-2806 94.4 µM 0.889998408804536 0.191454412547163 no 655 0.186733370237499 1012 845254
SGTC_2279 7948423 32.93 µM 0.887760920666007 0.192060971784442 no 656 0.18733468410646 915 1247112
SGTC_3219 9131112 49.47 µM 0.886604213660971 0.192375003318607 no 657 0.187646012243672 883 17612988 YMR079W SEC14
SGTC_2305 7443522 69.23 µM 0.886030988090329 0.192530743202401 no 658 0.187800414511322 955 5415886
SGTC_880 0833-0487 87.2 µM 0.884182486097941 0.193033488221267 no 659 0.188298855559581 910 76075
SGTC_2697 mebhydrolin 72.4 µM 0.88073365041037 0.19397362337025 no 660 0.189230999464534 958 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_3223 9129970 49.47 µM 0.878540761962444 0.194572842103092 no 661 0.189825163534922 966 17248386
SGTC_2683 piperine 63.03 µM 0.878423858929658 0.194604818090246 no 662 0.189856870636912 904 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3214 9129694 49.47 µM 0.877599330549108 0.19483043861622 no 663 0.190080596358186 895 17158655
SGTC_2323 6148992 148.28 µM 0.876856878338584 0.195033736226365 no 664 0.190282190281523 832 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1659 st012954 42.1 µM 0.875001128286286 0.195542439790481 no 665 0.190786645896739 911 24207262
SGTC_474 dl-dihydrosphingosine 5 µM 0.87336618026845 0.195991283424153 no 666 0.191231759349315 965 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2284 7945075 39.21 µM 0.873030659036937 0.196083471578904 no 667 0.191323183434998 1017 1245402
SGTC_1008 4106-0037 6 µM 0.870317764420128 0.1968298348912 no 668 0.192063386747853 951 2905394
SGTC_1665 st014639 11.4 µM 0.869429447540315 0.197074599299113 no 669 0.192306141076708 1008 981133 YIL048W NEO1
SGTC_2930 9013230 14.89 µM 0.868999021386926 0.197193263967639 no 670 0.192423833018095 961 2995857
SGTC_3309 9129340 25.759 µM 0.867823400674654 0.197517592375078 no 671 0.192745508748524 989 17158987
SGTC_2873 9040596 71.43 µM 0.866618930666024 0.197850213939376 no 672 0.193075418817486 939 6463863
SGTC_1913 st060213 96.1 µM 0.861832670267906 0.199175308885175 no 673 0.194389802015175 1006 688959
SGTC_2640 pentamidine 10.38 µM 0.859598479668044 0.19979567906545 no 674 0.19500520668808 1020 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2251 lansoprazole 556 µM 0.858887971277606 0.199993210044843 no 675 0.195201163200205 796 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_3178 9107506 49.47 µM 0.858566449131813 0.200082636143228 no 676 0.195289877552103 938 8897194
SGTC_1950 st077106 7.18 µM 0.856900676265865 0.200546328212381 no 677 0.195749889509008 942 13831864
SGTC_2007 4011539 71.82 µM 0.856779269082465 0.200580148876096 no 678 0.195783442437448 941 45595301
SGTC_2197 6588183 93.1375 µM 0.855635559158016 0.200898922707419 no 679 0.196099697314519 938 884136
SGTC_233 rapamycin 362 pM 0.854552684912959 0.201201020451715 no 680 0.196399415483967 1032 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2789 5281112 71.43 µM 0.853545838705582 0.201482152299061 no 681 0.196678339539413 937 765948
SGTC_312 4092-0653 6.84 µM 0.852011803703033 0.201910938181787 no 682 0.1971037703726 1028 1148278
SGTC_244 nsc-207895 1.295 µM 0.851838014308805 0.2019595493602 no 683 0.197152002127972 854 42640
SGTC_1319 1306-0155 43.7 µM 0.851455631902212 0.202066531407861 no 684 0.19725814982386 992 3122360
SGTC_1867 st057372 64 µM 0.85067142343422 0.202286041472063 no 685 0.19747595081991 997 688837
SGTC_1865 st057639 52.2 µM 0.849828598248908 0.202522118063718 no 686 0.197710193689776 1005 688818
SGTC_2316 5844804 197.44 µM 0.848912620635011 0.202778871440862 no 687 0.197964957827331 1098 776813
SGTC_1674 st016616 23.6 µM 0.848779223672207 0.202816279533292 no 688 0.198002076536488 954 625830
SGTC_2585 alliin 100 µM 0.848169942548811 0.202987190741891 no 689 0.198171667031689 984 87310 A garlic compound which reacts with lipids.
SGTC_1461 k072-0203 53.8 µM 0.847057611773358 0.20329943562019 no 690 0.198481505095187 928 5418714
SGTC_2626 ethyl orsellinate 100 µM 0.843424396215559 0.204321319001313 no 691 0.199495566253299 964 75653 A natural product.
SGTC_2581 avocatin a 64 µM 0.843128632474252 0.204404640323591 no 692 0.199578253451358 970 6710728 A skin care supplement.
SGTC_271 rotenone 740 µM 0.842874976434463 0.204476115349483 no 693 0.199649184951181 1031 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_35 0133-0054 64.071 µM 0.842780369405682 0.204502777461657 no 694 0.199675644417705 939 99677
SGTC_2774 tamoxifen 10.92 µM 0.842577524456781 0.204559950111128 no 695 0.199732382716767 999 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_824 1304-0008 100 µM 0.842196088961185 0.204667484965689 no 696 0.199839101315781 973 768245
SGTC_2659 sanguinarine 24.21 µM 0.841766110836727 0.204788745342372 no 697 0.199959442355824 935 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_874 0599-0792 117 µM 0.841454096524621 0.204876764874739 no 698 0.200046795299972 1051 765305
SGTC_40 0327-0103 19.753 µM 0.841178873953358 0.204954424091799 no 699 0.200123866900909 943 409036
SGTC_2314 7727897 200 µM 0.839430490432216 0.205448171908162 no 700 0.200613889929803 982 900724
SGTC_2466 5983409 37.09 µM 0.838211473502553 0.20579284284444 no 701 0.200955972159575 941 2879657
SGTC_2710 st078562 53.7235 µM 0.837858733125466 0.205892642390607 no 702 0.201055023901442 1011 17250908
SGTC_1300 1094-0077 113 µM 0.835371433918962 0.206597179487226 no 703 0.201754304251748 928 5532636
SGTC_369 0957-0393 4.5 µM 0.835322339258538 0.206611100093665 no 704 0.201768121387405 966 6997992
SGTC_737 1950-0117 57.9 µM 0.83420862851454 0.206927037801234 no 705 0.202081714860698 997 5393513
SGTC_83 0170-0301 39.027 µM 0.833457194244574 0.207140366281281 no 706 0.202293464903958 940 3089716
SGTC_2832 7992762 51.95 µM 0.833263858838356 0.207195274283144 no 707 0.202347967215771 854 2985177
SGTC_2664 lyso-paf C-16 73.48 µM 0.831392810154022 0.207727103967193 no 708 0.202875879710453 1043 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1687 st020778 55.3625 µM 0.829061420819011 0.208390908718066 no 709 0.203534826320602 1058 4259299
SGTC_1388 3346-4487 254 µM 0.829054966800365 0.208392748073152 no 710 0.203536652262031 1056 3345614
SGTC_797 k781-0471 270 µM 0.828395095030934 0.208580857947952 no 711 0.203723391725159 1022 23738129
SGTC_1014 4130-3005 69.3 µM 0.825729782813292 0.209341677540242 no 712 0.204478696783864 999 743608
SGTC_359 0081-0058 15.9 µM 0.823412167300091 0.210004571896152 no 713 0.205136823103998 951 3494159
SGTC_1846 st056244 14.8 µM 0.82087778038199 0.210730878127034 no 714 0.205857944316914 1019 5393182
SGTC_3244 9134489 49.47 µM 0.820165392434983 0.210935299719305 no 715 0.206060913925294 1001 16584271
SGTC_2286 7945697 125 µM 0.820115280393806 0.210949683876805 no 716 0.206075196035266 1020 1245733
SGTC_1236 0330-0013 258 µM 0.819745657693815 0.211055798119329 no 717 0.206180557950313 971 4617066
SGTC_1139 k015-0024 46.9 µM 0.81871343011819 0.211352303916088 no 718 0.206474966188707 1041 2766652
SGTC_2423 st077119 87.2 µM 0.818424591413519 0.211435316062265 no 719 0.206557392299885 1016 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1459 k035-0031 35.7 µM 0.818011886624224 0.21155396040573 no 720 0.206675199979679 896 3877128 YMR208W ERG12
SGTC_1355 1499-0035 1.68 µM 0.81645381719854 0.212002225296478 no 721 0.207120313544873 994 1548538
SGTC_2985 9022375 71.43 µM 0.81608763793848 0.212107657587818 no 722 0.207225006885305 1047 4939335
SGTC_1252 0493-0875 34.8 µM 0.815914500132489 0.212157519024009 no 723 0.207274519151356 980 3960963
SGTC_927 2425-1185 123 µM 0.815349940062502 0.212320152576505 no 724 0.207436015138311 1017 730375
SGTC_743 1275-0778 158 µM 0.814793433157129 0.212480537527654 no 725 0.207595280239123 1041 2849257 YMR203W TOM40
SGTC_3334 9142812 21.919 µM 0.814292556413138 0.212624950399262 no 726 0.207738686468665 987 45283678
SGTC_1482 3346-2049 8.48 µM 0.813763503615951 0.212777549223803 no 727 0.20789022332607 1006 3826804
SGTC_406 estrone 100 µM 0.813383317598103 0.212887248711712 no 728 0.207999160493577 1039 5870 A steroid.
SGTC_1396 3511-0007 98.6 µM 0.813130389314752 0.212960247327922 no 729 0.208071652340158 935 X1396
SGTC_910 3454-3003 490 µM 0.811833307556408 0.213334832591156 no 730 0.208443643572411 1019 820824
SGTC_2117 5521686 200 µM 0.807458193151801 0.214601154957109 no 731 0.209701275764767 1004 803312
SGTC_893 0958-0369 48.9 µM 0.807194700506544 0.214677558855116 no 732 0.209777159238686 1051 6819948
SGTC_1980 st071811 45.7 µM 0.806829501905755 0.214783480152832 no 733 0.209882359787428 1025 4974850
SGTC_540 1187-0821 17.3 µM 0.806108065752654 0.214992812923112 no 734 0.210090270639491 988 847520
SGTC_2419 paclitaxel 166.5 µM 0.805861879364476 0.215064273761792 no 735 0.21016124683189 1037 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1790 st045711 43.5 µM 0.802569224711211 0.216021361739075 no 736 0.211111881072995 1043 585119
SGTC_2595 hexamethylquercetagetin 100 µM 0.80225501116975 0.216112824122281 no 737 0.211202730336212 965 386331
SGTC_1398 3558-0053 112 µM 0.801690566832629 0.216277180884782 no 738 0.211365986913663 984 4532369
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.798899016719674 0.217091096862113 no 739 0.212174484577698 1039 6710655
SGTC_420 mitomycin C 81.9 mM 0.798326288600617 0.217258302390367 no 740 0.212340583162205 1018 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_145 3737-0113 38.366 µM 0.79664936659298 0.21774830011566 no 741 0.212827349038291 1128 6849351
SGTC_1502 4534-4282 27.7 µM 0.794941780898316 0.21824791228898 no 742 0.213323684435396 1009 3278949
SGTC_1510 1123-0200 71.5 µM 0.791719090998885 0.219192617019437 no 743 0.214262244053049 1098 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1362 1611-0397 101 µM 0.791254155258233 0.219329102836616 no 744 0.214397847545407 1077 27816
SGTC_1519 esterone 74 µM 0.790877674388223 0.219439657756012 no 745 0.214507688786409 1037 698 A steroid.
SGTC_77 0828-0286 12.516 µM 0.79058313893753 0.219526171434661 no 746 0.214593644615505 1070 745345
SGTC_2457 5731572 11.68 µM 0.788639854381028 0.220097461795333 no 747 0.215161265160289 1089 2865357
SGTC_1066 ketoconazole 628 nM 0.78863801483527 0.220098002992076 no 748 0.215161802891986 1093 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_1773 st048542 73.5835 µM 0.787106126702435 0.220548951386429 no 749 0.215609871586691 999 3237138
SGTC_397 arbidol 50 µM 0.784044886710995 0.22145168573004 no 750 0.216506886257869 1084 131410 A RNA synthesis inhibitor.
SGTC_764 1951-2361 146 µM 0.779155849689528 0.222897794220603 no 751 0.217943957046748 1027 5438930
SGTC_2008 4012253 172 µM 0.779014532151242 0.222939673806066 no 752 0.217985577179143 1058 603940
SGTC_2976 9009005 19.48 µM 0.777848181155552 0.223285494132212 no 753 0.218329259966792 1084 2993148
SGTC_2383 9036125 200 µM 0.77616287731292 0.223785721631973 no 754 0.218826410951554 1051 79580
SGTC_3053 9095903 49.47 µM 0.775136903080897 0.224090560316811 no 755 0.219129383736758 1109 17174018
SGTC_2345 9052315 157.45 µM 0.774682773224649 0.224225567190214 no 756 0.219263566398475 1042 6469265
SGTC_2743 auranofin 4.32 µM 0.774042693473303 0.224415932937702 no 757 0.219452772218737 1036 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_661 1304-0007 33.6 µM 0.77341561996624 0.224602519423171 no 758 0.219638224355544 1054 3117130
SGTC_2537 larixol 68.93 µM 0.772105576508669 0.224992608288052 no 759 0.220025949832761 1093 6708759
SGTC_2310 7668677 200 µM 0.77068137970531 0.225417123627474 no 760 0.220447905717723 1077 2197143
SGTC_451 chloral hydrate 100 µM 0.770209108094972 0.225557995337116 no 761 0.220587930971688 1122 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2084 5306078 60.6385 µM 0.769688576953947 0.225713319862326 no 762 0.220742323858625 1048 679340
SGTC_870 0573-2213 57.6 µM 0.766852453219123 0.226560670674943 no 763 0.221584622855209 1097 3916321
SGTC_413 propylparaben 100 µM 0.766749525447247 0.226591456213504 no 764 0.22161522582592 1057 7175 A pharmaceutical preservative.
SGTC_393 acivicin 6.25 µM 0.766353844229491 0.226709825842838 no 765 0.221732894120454 1001 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_131 0141-0277 33.849 µM 0.765983640569908 0.226820605347572 no 766 0.221843018172808 1058 1547771
SGTC_268 camptothecin 39.6153 µM 0.764882252916162 0.227150364393106 no 767 0.22217083133383 1111 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_587 k089-0003 57 µM 0.764610915652474 0.227231645121681 no 768 0.222251633628055 1032 9659696
SGTC_2276 7947513 42.08 µM 0.763559981012849 0.227546613629916 no 769 0.222564752637975 1035 2105100
SGTC_1027 k015-0025 8.67 µM 0.761886871343323 0.228048556894962 no 770 0.223063763147671 1124 3598955
SGTC_3169 9102970 49.47 µM 0.760210550991307 0.228552087300948 no 771 0.223564369591306 1138 17027839
SGTC_576 1073-0113 22.7 µM 0.759384205346336 0.228800533291025 no 772 0.223811379528953 1286 5439563
SGTC_2426 5582046 32.21 µM 0.759231611555257 0.228846428146223 no 773 0.223857009586081 1083 2251934
SGTC_2317 5986382 200 µM 0.757831988955358 0.229267626459066 no 774 0.22427578471634 1131 877883
SGTC_295 k015-0027 31 µM 0.756177228554447 0.229766165441921 no 775 0.224771471842528 1082 3887424
SGTC_2261 9010538 184.68 µM 0.755152051057254 0.230075330729621 no 776 0.225078877418062 1042 6457250
SGTC_1495 4469-0029 237 µM 0.751908931105891 0.23105489764961 no 777 0.226052913424248 1156 793680
SGTC_3275 9138069 49.47 µM 0.750755487991767 0.231403849292672 no 778 0.226399911126653 1097 17617007
SGTC_1752 st044819 83.042 µM 0.750172489499469 0.23158033582587 no 779 0.226575412691898 1087 441209 YML126C ERG13
SGTC_3043 9092303 49.47 µM 0.750143309546503 0.231589171213901 no 780 0.226584198827339 1082 25236084
SGTC_1744 st037937 38.9 µM 0.750108120635191 0.231599826302291 no 781 0.226594794526571 1135 1016152
SGTC_1966 st070145 16.1 µM 0.749213688050869 0.23187074931146 no 782 0.226864210148369 1099 3748532
SGTC_788 1182-0090 188 µM 0.74698046456005 0.232547961120287 no 783 0.227537676537474 1174 5715185
SGTC_866 0495-0101 262 µM 0.745526497456735 0.232989458445763 no 784 0.227976749381788 1060 635694
SGTC_1486 3970-0793 4.53 µM 0.745259351445639 0.233070627964928 no 785 0.228057474640907 1145 2844330
SGTC_2575 plumbagin 510 nM 0.744802795115795 0.233209384167212 no 786 0.228195472462618 1068 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1548 st061468 90.8 µM 0.741965839447017 0.234072616136311 no 787 0.229054016524919 1146 390799
SGTC_2920 7982904 15.77 µM 0.74148548074861 0.234218955192241 no 788 0.229199566005018 1074 6456808
SGTC_867 0518-0118 155 µM 0.741392759155153 0.234247208227689 no 789 0.229227666771894 1169 6848158
SGTC_807 1315-0151 48 µM 0.740269161973371 0.234589727480585 no 790 0.22956834443952 1166 4011080
SGTC_2606 farnesol 9.78 µM 0.739769994240685 0.234741983431499 no 791 0.229719784385626 1126 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2052 5265182 7.135 µM 0.739670539958662 0.234772325464226 no 792 0.229749963994433 1116 1239884
SGTC_2083 5306046 65.942 µM 0.739574469540419 0.234801637188693 no 793 0.229779118870907 1143 539837
SGTC_1239 0337-0584 35.4 µM 0.738822040114662 0.23503127837152 no 794 0.230007533295782 1169 914301 YML130C ERO1
SGTC_1726 st035556 14.5795 µM 0.738816762067707 0.235032889667615 no 795 0.230009135997129 1136 5919439
SGTC_55 0767-0285 6.563 µM 0.738282222253325 0.235196106993972 no 796 0.230171483643616 1120 3116166
SGTC_1198 1612-1005 86.7 µM 0.738208440273025 0.235218640628394 no 797 0.230193897355619 1159 6998509
SGTC_2863 9028737 58.44 µM 0.738149802701151 0.235236549883854 no 798 0.230211711324327 1116 6460917
SGTC_2989 9073649 71.4286 µM 0.73760602223034 0.235402668736679 no 799 0.230376947393464 1147 21367202
SGTC_2021 4019055 173 µM 0.737324966540345 0.235488553480294 no 800 0.230462376478954 1162 44827708 YER133W GLC7
SGTC_2358 9037157 4 µM 0.737229310248955 0.235517787986553 no 801 0.230491455998946 1123 2388925
SGTC_2307 7538926 6.34 µM 0.735052300781381 0.236183667416647 no 802 0.231153821250767 1142 96582
SGTC_403 arphamenine a 50 µM 0.733096992151606 0.236782618307676 no 803 0.231749637270028 1105 5487158 An arginine aminopeptidase inhibitor.
SGTC_2092 5303694 80.6725 µM 0.732582748208929 0.236940280325625 no 804 0.231906478194779 1120 1963699
SGTC_2936 9038235 15.59 µM 0.732168347156959 0.237067373495305 no 805 0.232032910714075 1144 4749415
SGTC_3271 9137798 49.47 µM 0.731880383336567 0.237155711530444 no 806 0.232120790207064 1081 6498326
SGTC_2711 st079103 59.1 µM 0.731278637522651 0.237340366151344 no 807 0.232304488057354 1141 54693780
SGTC_1506 4226-2149 212 µM 0.730897194270451 0.237457458539525 no 808 0.232420974953134 1166 991114
SGTC_2528 xanthyletin 44.79 µM 0.730735445975397 0.237507120306074 no 809 0.232470380199095 1150 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_604 1000-0114 314 µM 0.730377391700677 0.237617074400004 no 810 0.232579766942154 1173 1572745
SGTC_1777 st045864 34.765 µM 0.728929761519716 0.238061908571706 no 811 0.233022314261662 1150 4691462
SGTC_501 nsc-95397 161 µM 0.726902120549758 0.238685737622891 no 812 0.233642959032222 1135 262093
SGTC_1813 st051246 8.6015 µM 0.72663056968959 0.238769351499699 no 813 0.233726148126201 1106 5291959
SGTC_1284 0929-0043 16 µM 0.725913118195035 0.238990340784995 no 814 0.233946017013737 1116 1239883
SGTC_2094 5332512 191.667 µM 0.722935587109706 0.239908673354363 no 815 0.234859729276716 1179 755774
SGTC_1618 st003135 44.5 µM 0.720629557435907 0.240621221304572 no 816 0.235568731660472 1123 1270615
SGTC_1358 1509-0022 2.48 µM 0.719653311409554 0.240923221626083 no 817 0.235869239618342 1181 3258434
SGTC_80 0159-0065 512.242 µM 0.719383331350974 0.24100677595142 no 818 0.235952382139457 1098 1548079
SGTC_1385 3091-4834 14.1 µM 0.718933818109375 0.241145927756928 no 819 0.236090849169479 1108 4072814
SGTC_2227 7312221 64.1025 µM 0.718580412519841 0.241255359033203 no 820 0.236199742844222 1178 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2224 6650123 117.647 µM 0.717807990746745 0.241494631689755 no 821 0.236437842840575 1138 2908370
SGTC_2002 4023503 131 µM 0.71703693653416 0.241733609200581 no 822 0.236675652985476 1232 4736863 YCR052W RSC6
SGTC_1010 4112-3296 15.2 µM 0.71579827661881 0.242117783153375 no 823 0.237057958361512 1197 704384
SGTC_1205 4161-2785 76 µM 0.715705976056146 0.242146423686709 no 824 0.237086459987873 1101 3498106
SGTC_1020 4335-0961 93.3 µM 0.715479332712869 0.242216758094624 no 825 0.23715645350667 1081 669075
SGTC_2953 9074162 66.49 µM 0.715444497849313 0.242227569407119 no 826 0.237167212449526 1105 16451992
SGTC_2018 5133068 143 µM 0.715049278906939 0.242350247468796 no 827 0.237289296812285 1150 785362
SGTC_686 1319-0111 510 µM 0.714608266231195 0.242487179883209 no 828 0.237425567736504 1204 4562600
SGTC_643 k048-0106 28.4 µM 0.71446283583932 0.242532344540134 no 829 0.237470514488731 1164 6763920
SGTC_1487 3970-0795 2.82 µM 0.71388001649688 0.242713389797542 no 830 0.237650687634498 1189 3765103
SGTC_3325 9138760 55.175 µM 0.711944805440039 0.243315062379718 no 831 0.238249477669038 1161 43844959
SGTC_1887 st057648 70.8 µM 0.711471143477355 0.243462450368905 no 832 0.238396163229328 1158 688672
SGTC_1526 st051518 75 µM 0.711420557232624 0.243478193990919 no 833 0.238411831905386 1089 673993
SGTC_520 3584-0023 682 µM 0.710983265622573 0.243614312286791 no 834 0.238547302913597 1119 1340790
SGTC_210 3551-0445 56.827 µM 0.710249977579149 0.243842659311615 no 835 0.238774566849223 1199 2865180 YOR207C RET1
SGTC_2222 6885208 172.143 µM 0.710072126933991 0.243898059676612 no 836 0.238829704964923 1126 609514
SGTC_2695 st077686 51.995 µM 0.707785474041599 0.244610955280007 no 837 0.239539244164491 1174 2876092
SGTC_677 0929-0063 136 µM 0.707173508418389 0.244801934189634 no 838 0.239729329661168 1134 1539583
SGTC_709 3807-1509 243 µM 0.707150908322957 0.24480898864117 no 839 0.239736351157873 1207 1886677 YPL242C IQG1
SGTC_2071 5230951 39.92 µM 0.705664081603677 0.245273330841347 no 840 0.240198531448976 1234 1799272
SGTC_1677 st019204 53.9 µM 0.703485028128418 0.245954712906805 no 841 0.240876766961562 1128 3945625
SGTC_1673 st016611 27.3 µM 0.700468667208124 0.246899591593093 no 842 0.241817333051815 1185 5226799
SGTC_2807 7945238 51.95 µM 0.700467622686181 0.246899919126999 no 843 0.241817659101 1209 17148797
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.700453386879988 0.246904383114994 no 844 0.241822102854317 1148 689007
SGTC_3203 9113543 49.47 µM 0.70003096084112 0.247036864869637 no 845 0.241953984683415 1196 17018012
SGTC_1653 st012112 65 µM 0.697930817960299 0.247696078328733 no 846 0.242610230140154 1185 720429
SGTC_479 n-linoleoylglycine 10 µM 0.695968424382369 0.248312901673104 no 847 0.243224302159999 1192 6433346 An anti-infammatory.
SGTC_1523 st012844 44.7 µM 0.695836802500394 0.248354302602232 no 848 0.243265519313804 1218 4274103
SGTC_965 1291-5240 308 µM 0.695494985606192 0.248461836384069 no 849 0.243372576285961 1184 2834598
SGTC_427 1354-0053 47.3 µM 0.694632037400226 0.248733425666878 no 850 0.24364296469608 1233 6813657
SGTC_486 niguldipine 82 µM 0.69315323986282 0.249199203958094 no 851 0.244106694695183 1201 1236 A calcium channel blocker.
SGTC_2798 7813637 45.45 µM 0.692622777702845 0.249366397106364 no 852 0.244273156051929 1182 956368
SGTC_3337 9144342 33.5465 µM 0.691499006167153 0.249720788705991 no 853 0.24462600252789 1202 17682949
SGTC_2706 st078239 82.5 µM 0.689644452571542 0.250306223492945 no 854 0.245208902753409 1212 15434492
SGTC_614 0462-0418 107 µM 0.689113537257791 0.250473953650828 no 855 0.245375910848589 1101 5188303
SGTC_2267 7931562 200 µM 0.688910274271294 0.25053818555557 no 856 0.245439866724286 1140 934880
SGTC_3298 9116858 71.43 µM 0.688758560914016 0.250586133261689 no 857 0.2454876085552 1213 2506942
SGTC_1192 1488-0095 21.4 µM 0.688747036081374 0.250589775784913 no 858 0.245491235444452 1191 915875
SGTC_769 0302-0231 76 µM 0.686784250893084 0.251210540014109 no 859 0.246109347864264 1218 571869 YER009W NTF2
SGTC_659 k018-0002 107 µM 0.686637872539285 0.251256867223993 no 860 0.246155478171567 1201 6797879 YHR007C ERG11
SGTC_3120 9124077 49.47 µM 0.686196703081225 0.251396520039621 no 861 0.246294538266352 1264 18774327 YGL155W CDC43
SGTC_812 4251-0442 148 µM 0.686101772427423 0.251426575835398 no 862 0.246324466662792 1202 5723007
SGTC_2409 alverine citrate 63.97 µM 0.684549546080897 0.251918292254905 no 863 0.246814107097923 1263 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2336 9001819 198.65 µM 0.684185564909169 0.252033668133976 no 864 0.246928998129613 1259 2989602
SGTC_289 k017-0060 526 µM 0.684117138249188 0.252055361341449 no 865 0.246950600270939 1194 5512909
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.683566780050957 0.252229876443322 no 866 0.247124383877237 1187 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2999 9069765 71.4286 µM 0.682520523017312 0.252561813544246 no 867 0.247454935046802 1232 2097066
SGTC_615 k087-0205 167 µM 0.682362647204261 0.252611921441204 no 868 0.247504834344992 1197 9642773
SGTC_2600 tangeritin 87.95 µM 0.681712280730291 0.252818395197255 no 869 0.247710450255507 1198 68077 A bioactive flavone.
SGTC_3131 9127911 49.47 µM 0.681365406264464 0.252928554771957 no 870 0.24782015326613 1263 45595681
SGTC_2272 7805186 180 µM 0.680713170879461 0.253135758534278 no 871 0.24802650036931 1199 2956062 YPR165W RHO1
SGTC_1464 k208-0027 110 µM 0.680632023357419 0.253161543924846 no 872 0.248052179346074 1239 X1464
SGTC_941 3237-0776 460 µM 0.677232868830588 0.254242897031578 no 873 0.249129108167393 1224 760008
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.676820550104983 0.254374230075912 no 874 0.249259908964933 1253 279621
SGTC_64 000l-0018 272.079 µM 0.674410143343233 0.255142711311155 no 875 0.250025297872 1184 6811119
SGTC_2139 5578692 56.4705 µM 0.672987379060032 0.255596883468248 no 876 0.250477660144612 1185 650991 YMR113W FOL3
SGTC_913 3487-1245 167 µM 0.67202263767921 0.255905086474758 no 877 0.250784642422351 1192 4016153
SGTC_300 r073-0011 5.04 µM 0.671884367855672 0.255949275000661 no 878 0.250828656420832 1269 2735780
SGTC_932 2857-0803 154 µM 0.670928538473162 0.256254849574875 no 879 0.251133027484169 1307 674898
SGTC_1808 st050063 61.5 µM 0.670597902164494 0.256360596847624 no 880 0.251238359647934 1230 4011993
SGTC_600 1495-0418 41.6 µM 0.66964483517645 0.256665543077722 no 881 0.251542112782606 1237 5377768
SGTC_2128 5255449 168.493 µM 0.667488194875526 0.257356284944581 no 882 0.252230173881581 1241 736008
SGTC_3212 9128307 49.47 µM 0.66687218707754 0.257553760889553 no 883 0.252426888959515 1193 27243542
SGTC_1316 1272-0050 65.9 µM 0.666614689119724 0.257636331299903 no 884 0.252509141958302 1242 7340392
SGTC_2715 st079500 56.4 µM 0.665253976952668 0.258072891279638 no 885 0.252944030881635 1212 28246688
SGTC_1661 st013063 9.66 µM 0.665105483472867 0.258120555942776 no 886 0.252991513821213 1285 721395
SGTC_917 harmaline 728.087 nM 0.664895059139159 0.258188107499233 no 887 0.253058808079246 1241 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2808 7946468 45.46 µM 0.660798711046584 0.25950496276185 no 888 0.254370704770427 1251 2970879
SGTC_856 0433-0016 11.3 µM 0.660370270273663 0.259642893941812 no 889 0.254508122861286 1254 3911780
SGTC_386 1509-0011 3.07 µM 0.659332391685519 0.259977182864538 no 890 0.254841173198625 1285 3107280
SGTC_144 4161-2749 112.381 µM 0.658847810795621 0.260133336848551 no 891 0.254996751002553 1185 797501 YMR168C CEP3
SGTC_2121 5257820 149.641 µM 0.65743949430273 0.260587434706765 no 892 0.255449181963767 1291 791256
SGTC_129 0088-0017 176.636 µM 0.656994809048223 0.260730903833064 no 893 0.255592127116385 1182 182446
SGTC_2520 obtusaquinone 4.71 µM 0.656573171246488 0.260866974673605 no 894 0.255727702186988 1313 5967872
SGTC_1357 1503-1303 39.5 µM 0.655976910655885 0.261059462067065 no 895 0.255919490225809 1265 292895
SGTC_1489 4065-0444 182 µM 0.653881753637732 0.261736408187277 no 896 0.256593995116081 1231 2877968
SGTC_722 3534-0461 190 µM 0.653244186756081 0.261942584899233 no 897 0.256799433953809 1233 658262
SGTC_1122 capsaicin 818.572 nM 0.652591915970921 0.262153602711732 no 898 0.257009699293629 1301 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2375 9072683 200 µM 0.652040728497121 0.26233198668114 no 899 0.257187449310129 1311 16798029
SGTC_3166 9102297 49.47 µM 0.651413949560568 0.262534910262547 no 900 0.257389654121284 1222 25237072
SGTC_672 1441-0018 53.7 µM 0.65131627296282 0.262566540903344 no 901 0.257421172953367 1240 251141
SGTC_1694 st024011 44.9 µM 0.649788063001073 0.26306167542098 no 902 0.257914565313002 1318 2787533
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.649125947858482 0.263276346396693 no 903 0.258128485658301 1228 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1793 st048256 72.231 µM 0.648079411458498 0.263615836805363 no 904 0.258466794782516 1200 672022
SGTC_838 0109-0203 71.4 µM 0.647941860685227 0.263660474088965 no 905 0.258511277274945 1271 759422
SGTC_783 0848-0141 92.7 µM 0.647885235841097 0.263678850818242 no 906 0.258529590313855 1261 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1191 1487-1166 10.6 µM 0.647516762354111 0.263798449223654 no 907 0.258648774720812 1324 3955771
SGTC_351 caspofungin 25 nM 0.647302549835124 0.263867990617873 no 908 0.258718075797029 1306 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1375 2910-0797 186 µM 0.646839848228241 0.264018232752257 no 909 0.258867799746547 1267 742508
SGTC_2202 7226349 200 µM 0.645979352897404 0.264297756894032 no 910 0.259146363500586 1235 844334
SGTC_1279 0874-0590 65.2 µM 0.645328128924203 0.264509401248012 no 911 0.259357283878796 1306 3523074
SGTC_1 0258-0098 57.368 µM 0.645061336639344 0.264596132227575 no 912 0.259443718969846 1199 6790032 YDR047W HEM12
SGTC_696 1560-0013 611 µM 0.644676426769149 0.264721287307896 no 913 0.259568447888223 1313 1650269
SGTC_1265 0819-1001 68.8 µM 0.644123483795136 0.26490113173578 no 914 0.259747681613735 1267 3106768
SGTC_1511 0906-3109 28.5 µM 0.643362398144221 0.26514877598531 no 915 0.259994488172684 1310 2882180
SGTC_2468 5987765 72.9 µM 0.642286811679228 0.26549895379953 no 916 0.260343487865774 1323 26772094
SGTC_982 1491-0518 27.5 µM 0.642232173458776 0.265516748580743 no 917 0.26036122297922 1252 3091256
SGTC_1834 st055981 52.8 µM 0.640299279900064 0.266146649681573 no 918 0.260989024408713 1342 471719 YDL150W RPC53
SGTC_3100 9120536 49.47 µM 0.639470367441918 0.266417011484078 no 919 0.261258492425267 1182 16421196
SGTC_3149 9097855 49.47 µM 0.63735673845485 0.267107030475952 no 920 0.261946250453173 1293 25236625 YMR079W SEC14
SGTC_801 0866-0028 10.1 µM 0.636059534809927 0.267530964182783 no 921 0.262368809411648 1308 6849771
SGTC_204 PMA1.184 62.41 µM 0.635580182707863 0.267687705041989 no 922 0.262525044745278 1305 2252213 YGL008C PMA1
SGTC_2059 5238311 157 µM 0.635540896908057 0.26770055295365 no 923 0.262537851285463 1287 703021
SGTC_844 0330-0132 15.3 µM 0.633166801127763 0.268477546585545 no 924 0.263312361496229 1285 2828079
SGTC_180 1486-1293 102.781 µM 0.633093446999309 0.268501571956539 no 925 0.263336310659266 1349 4140536
SGTC_809 3998-0021 90 µM 0.632707432192451 0.268628019578955 no 926 0.263462357767043 1238 715485
SGTC_1597 7-benzyloxygramine 47.5 µM 0.63225910587304 0.268774916256192 no 927 0.263608790370475 1282 260807
SGTC_3124 9127567 49.47 µM 0.631131091550252 0.269144694975578 no 928 0.263977406652013 1271 17592030
SGTC_373 0844-0104 25.9 µM 0.630934153170825 0.269209280266533 no 929 0.264041789757761 1304 5375804
SGTC_2669 eugenol 100 µM 0.628039642210061 0.270159421494858 no 930 0.264988985556928 1286 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1525 8-methoxypsoralen 92.5 µM 0.625682353228998 0.270934453512708 no 931 0.265761655110792 1348 4114 Related to psoralen; DNA damaging agent.
SGTC_95 0471-0001 561.058 µM 0.623851079377896 0.271537306441572 no 932 0.266362695270559 1227 4015405
SGTC_592 k241-0073 46.5 µM 0.623060012974834 0.271797930924022 no 933 0.266622542779353 1325 4230158
SGTC_2395 5646831 180.19 µM 0.62270856414519 0.271913759066296 no 934 0.266738026915219 1349 6808628
SGTC_3029 9088683 49.47 µM 0.622449195481143 0.271999255791229 no 935 0.266823270230264 1304 25236615
SGTC_499 genistein 192 µM 0.622401670445372 0.272014923107052 no 936 0.266838891155833 1317 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_293 4049-0273 38.5 µM 0.622249323755423 0.272065149423097 no 937 0.266888968852497 1243 1380311
SGTC_1323 1348-1351 11.2 µM 0.62174098914544 0.27223277273282 no 938 0.267056097253402 1308 6989654
SGTC_2194 5927483 104.545 µM 0.620100641901349 0.27277402692215 no 939 0.267595764802925 1320 760979
SGTC_307 1501-1223 22.3 µM 0.619445560680851 0.272990328683053 no 940 0.267811437363867 1289 2830329
SGTC_1643 st009866 20.2 µM 0.61916752874305 0.27308215795575 no 941 0.267903000354525 1303 3156273 YOR207C RET1
SGTC_1630 st005209 31.3 µM 0.618465113335373 0.27331422212821 no 942 0.268134393828581 1326 3367314
SGTC_416 estradiol valerate 100 µM 0.617843984864312 0.273519512042108 no 943 0.268339093087397 1310 13791 A steroid.
SGTC_2913 7966556 36.57 µM 0.617075292733625 0.273773679024272 no 944 0.268592532245799 1294 2976516
SGTC_2730 imipramine 71.33 µM 0.61600141531903 0.274128950558705 no 945 0.268946792844015 1329 3696 A tricyclic antidepressant.
SGTC_179 1273-0063 6.77 µM 0.615742034124611 0.274214795937371 no 946 0.269032395066567 1276 3108139
SGTC_1701 st028638 40.4 µM 0.615730823617059 0.274218506491251 no 947 0.269036095120162 1331 3490878
SGTC_2504 purpurogallin 52.29 µM 0.615083722604787 0.274432731778504 no 948 0.269249715562522 1289 5281571 An antioxidant.
SGTC_2373 9071805 200 µM 0.614052228066889 0.274774382701643 no 949 0.269590407472214 1357 10149009
SGTC_1203 3992-3522 103 µM 0.612375567156539 0.27533017224926 no 950 0.270144651621763 1547 5322312
SGTC_831 k061-1017 217 µM 0.611521858568599 0.275613377072941 no 951 0.270427075974795 1360 1240153
SGTC_1832 st054113 55 µM 0.611389499433817 0.275657298021819 no 952 0.270470876306425 1317 1251267
SGTC_3353 9151644 39.2805 µM 0.608984877538009 0.276455826219233 no 953 0.271267231307264 1324 4909158
SGTC_1195 1502-0147 41.1 µM 0.607561189283053 0.276929139431943 no 954 0.271739274040462 1316 817940
SGTC_756 0508-1999 28.3 µM 0.607531684805054 0.276938952557558 no 955 0.271749060964165 1277 6753853
SGTC_2415 st077333 57.7 µM 0.606564211980226 0.277260826218138 no 956 0.272070078314584 1428 2766255
SGTC_1859 st055998 20 µM 0.606383833405682 0.277320857553317 no 957 0.272129950612743 1375 676301
SGTC_717 1532-0246 73.2 µM 0.605888628246797 0.277485698195084 no 958 0.272294355635511 1308 9561992
SGTC_360 0957-0399 1.01 µM 0.603323496870068 0.278340327986544 no 959 0.273146752330317 1361 6752301 YPR165W RHO1
SGTC_2612 dictamnine 15.46 µM 0.602383520945624 0.278653822480158 no 960 0.273459438341976 1322 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2408 sulbentine 18.36 µM 0.601782173252232 0.278854470084653 no 961 0.273659571487333 1411 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2974 9094440 9.66 µM 0.601714807731107 0.278876951859274 no 962 0.273681995764517 1445 25236134
SGTC_1000 4048-0884 8.67 µM 0.600734349234209 0.279204258304136 no 963 0.274008468441479 1339 13040088
SGTC_768 0384-0033 77.3 µM 0.600672230472343 0.279225001697455 no 964 0.274029159203309 1314 3965305 YMR134W ERG29
SGTC_3045 9092950 49.47 µM 0.600601870706166 0.279248497923949 no 965 0.274052595843784 1429 44120432
SGTC_970 1315-0089 19.5 µM 0.599937568450346 0.279470385071924 no 966 0.274273921868049 1264 6811083 YLR033W RSC58
SGTC_1326 1431-2094 10.8 µM 0.599454208194509 0.279631888612529 no 967 0.274435018781092 1309 616278
SGTC_392 N-ethylmaleimide 8.33 µM 0.599431972394701 0.279639319275508 no 968 0.274442430771776 1290 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1553 gossypol 38.6 µM 0.599268564758855 0.279693929069232 no 969 0.27449690343623 1276 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1308 1187-1617 41.4 µM 0.598689983867393 0.279887328719779 no 970 0.274689818833917 1334 2882570
SGTC_2692 st077426 47.7 µM 0.598142094789019 0.280070528921343 no 971 0.274872562316585 1326 25238571
SGTC_3352 9151559 45.5865 µM 0.596124236971102 0.280745750126508 no 972 0.27554611693587 1299 17159339
SGTC_110 0850-0284 111.64 µM 0.593001863752969 0.281792116405865 no 973 0.276589952481035 1222 3906265
SGTC_2072 5231554 129 µM 0.592644276551908 0.281912070488477 no 974 0.276709620466281 1395 789545
SGTC_1748 st037455 53.6035 µM 0.59240350404827 0.281992852461436 no 975 0.276790210235147 1366 580690
SGTC_153 4077-0274 519.67 µM 0.592374490133855 0.282002587719549 no 976 0.276799922355507 1449 3121976
SGTC_3033 9090887 49.47 µM 0.588228015486292 0.283395547678663 no 977 0.278189627649866 1314 19325384
SGTC_3025 9087895 49.47 µM 0.588207731953898 0.283402369795397 no 978 0.27819643409977 1361 17173641
SGTC_1446 4239-0190 62 µM 0.586988259558055 0.283812668930927 no 979 0.278605795876882 1344 1340085
SGTC_34 0469-0683 81.75 µM 0.581858340577078 0.285541769675556 no 980 0.280331051650148 1398 3690923
SGTC_1259 0671-0132 43 µM 0.581057901781017 0.285812018753566 no 981 0.280600715113132 1344 X1259
SGTC_811 0416-0114 265 µM 0.580996526603962 0.285832745638938 no 982 0.280621397255197 1372 6612453
SGTC_1488 4013-0813 75.9 µM 0.580500265632774 0.286000363164761 no 983 0.280788653836804 1343 2910057
SGTC_2432 5630864 12.22 µM 0.578859641525582 0.286554834004297 no 984 0.281341942007225 1345 5714970
SGTC_3108 9121785 49.47 µM 0.575927402378729 0.287547091590972 no 985 0.282332126431053 1377 17140271
SGTC_1085 doxorubicin 7.67 µM 0.575344984796154 0.287744372491151 no 986 0.282529001750064 1421 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_678 1218-2179 85.9 µM 0.574859724832861 0.287908792246569 no 987 0.282693085153337 1402 6820081 YOR116C RPO31
SGTC_197 4544-0043 41.561 µM 0.574605421692231 0.287994975032293 no 988 0.282779092242248 1378 896523
SGTC_2443 5493264 126.67 µM 0.57450474230381 0.288029098424601 no 989 0.282813146184055 1430 5340055
SGTC_1518 st038567 90.8 µM 0.574316675258215 0.288092845337381 no 990 0.282876763529443 1346 77966
SGTC_2003 4023581 200 µM 0.57331301801348 0.288433155957501 no 991 0.283216386316469 1402 16641307
SGTC_1763 st044482 94.5 µM 0.573022447935576 0.288531715073024 no 992 0.283314747437903 1409 88505
SGTC_871 0574-0004 149 µM 0.5726711947115 0.288650878622729 no 993 0.283433672328509 1391 9551173
SGTC_1034 k072-0165 12.7 µM 0.572385828816643 0.288747706791055 no 994 0.283530307156512 1425 5835461
SGTC_309 k408-0051 1.48 µM 0.571922067353134 0.288905099391599 no 995 0.28368738660574 1357 3640463
SGTC_2998 9066762 71.4286 µM 0.569207694666489 0.289827119131694 no 996 0.284607599701501 1464 4945196
SGTC_1033 k072-0102 21.3 µM 0.568834138705222 0.289954116822864 no 997 0.284734352267111 1394 5965931
SGTC_746 1095-0025 46.6 µM 0.566863762811879 0.290624416252687 no 998 0.285403372801684 1408 6749286
SGTC_417 st075190 100 µM 0.566301931338901 0.290815677653165 no 999 0.285594273870844 1472 222757
SGTC_1207 2099-0101 141 µM 0.564454016939778 0.291445168355756 no 1000 0.286222592980296 1417 5837381
SGTC_448 monastrol 171 µM 0.563822291928563 0.291660510718806 no 1001 0.286437539600125 1388 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_3061 glucosamine 200 µM 0.563474120911334 0.291779226917284 no 1002 0.28655603872801 1356 91431 and experimental redox chemotherapeutic
SGTC_2678 equilin 100 µM 0.563181806051658 0.291878915172865 no 1003 0.28665554530825 1468 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_641 4092-0595 30 µM 0.562311816087732 0.292175702032971 no 1004 0.286951794550436 1413 786260
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.561186853990308 0.292559677683976 no 1005 0.287335081872424 1394 7104
SGTC_2849 9019321 12.99 µM 0.560481839311996 0.292800435003319 no 1006 0.287575411755722 1389 16489627
SGTC_2467 5474540 200 µM 0.559141620444885 0.293258363336345 no 1007 0.288032535917244 1354 5413519
SGTC_1534 6-azauridine 81.6 µM 0.558570853147868 0.293453484852854 no 1008 0.288227318290642 1393 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1154 4088-0362 150 µM 0.557563163703222 0.293798118547485 no 1009 0.288571358093014 1381 6618304
SGTC_2712 st079126 47.7 µM 0.555050930663801 0.294658126296456 no 1010 0.289429912294622 1353 3152970
SGTC_2653 dihydrofissinolide 100 µM 0.553963967593489 0.295030583751892 no 1011 0.289801752828399 1424 6857746
SGTC_557 1315-0110 16.2 µM 0.553774042190436 0.295095685612804 no 1012 0.289866747637584 1374 6833801
SGTC_2447 5741742 33.78 µM 0.552662922663012 0.295476683167889 no 1013 0.290247123340337 1488 1776504
SGTC_887 0885-0007 9.62 µM 0.551567679363739 0.295852458097897 no 1014 0.29062229271431 1463 5719458
SGTC_1756 st041558 35.5 µM 0.550347779638308 0.296271260502692 no 1015 0.29104042930697 1544 3955792
SGTC_1880 MG-132 525 µM 0.546996564699438 0.297423159336509 no 1016 0.292190546117825 1420 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1728 st035614 33.7865 µM 0.546372464004904 0.297637904542804 no 1017 0.292404967081146 1461 15945546
SGTC_2164 5685496 200 µM 0.546274619033804 0.297671578183202 no 1018 0.292438590104764 1417 759046
SGTC_2853 9015042 58.44 µM 0.546164024553847 0.297709641698151 no 1019 0.29247659647831 1326 6457456
SGTC_2198 6589944 200 µM 0.545776077688505 0.297843179671215 no 1020 0.292609934603842 1409 5290268
SGTC_1736 st036774 51 µM 0.544284477622985 0.298356868254831 no 1021 0.293122863428445 1491 1272247
SGTC_1898 st060199 18.6 µM 0.544279768940195 0.298358490505213 no 1022 0.293124483302105 1403 688866
SGTC_586 0957-0265 8.15 µM 0.544025596113765 0.298446064893512 no 1023 0.293211929598425 1347 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_3320 9137005 35.139 µM 0.543700429821718 0.298558116890647 no 1024 0.293323818305963 1412 4908713
SGTC_1920 st075728 45.7 µM 0.542059766507926 0.299123779541513 no 1025 0.293888666993651 1520 3400306
SGTC_2980 9014342 25.29 µM 0.541179051313596 0.299427630235255 no 1026 0.294192087590116 1414 2996599
SGTC_344 k064-0035 6.43 µM 0.541165848549541 0.299432186312625 no 1027 0.294196637256292 1380 5088750
SGTC_1317 1273-0028 910 nM 0.538752852921393 0.300265402449031 no 1028 0.29502869970665 1405 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1364 1653-0028 37.6 µM 0.538497497080849 0.300353639037472 no 1029 0.29511681630783 1434 5718652
SGTC_3201 9113999 49.47 µM 0.536550066814928 0.301026946249238 no 1030 0.295789221697104 1517 16649224
SGTC_1707 st032323 6.317 µM 0.535757638234521 0.301301116209257 no 1031 0.296063031400977 1398 3132057 YMR211W DML1
SGTC_278 4092-0821 23.9 µM 0.533299387583509 0.302152353461394 no 1032 0.29691317576907 1466 877900
SGTC_492 tmb-8 126 µM 0.533107644437908 0.302218795190909 no 1033 0.296979533824664 1366 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_460 trequinsin 123 µM 0.533096161450871 0.302222774417469 no 1034 0.296983508047433 1460 5537 A vasodilator.
SGTC_1649 st011737 51.3 µM 0.53224751711453 0.302516922194808 no 1035 0.297277288279835 1409 1761035
SGTC_2700 st077718 96.8 µM 0.531814489508974 0.302667062900384 no 1036 0.297427243159572 1433 904970
SGTC_860 0443-0016 25.1 µM 0.531351274431446 0.302827707249498 no 1037 0.297587690013042 1449 5337942
SGTC_1220 1838-0075 193 µM 0.529757967474386 0.303380562054085 no 1038 0.298139875639973 1426 5529645
SGTC_1848 st056003 16.4 µM 0.528486832519815 0.303821950925528 no 1039 0.298580741918698 1463 146492
SGTC_1091 telmisartan 47.6 µM 0.52814646838673 0.303940187566205 no 1040 0.298698840327042 1504 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1693 xanthone 101.9 µM 0.526627295063917 0.304468172199714 no 1041 0.299226216732365 1480 7020 An insecticide.
SGTC_1011 4112-3381 17.4 µM 0.526097338304748 0.304652453240169 no 1042 0.299410288961618 1480 2877139
SGTC_1881 5652484 16 µM 0.524772356970165 0.305113403823345 no 1043 0.299870725103815 1502 2255129
SGTC_2675 theaflavin digallate 100 µM 0.523131077890785 0.305684820795588 no 1044 0.300441519933504 1454 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1379 2144-0755 36.5 µM 0.522808007611745 0.305797354646703 no 1045 0.300553933291529 1498 5392327
SGTC_138 0850-0259 40.9225 µM 0.52248974908759 0.305908230370261 no 1046 0.300664690950303 1441 6813004
SGTC_459 nigericin 15.3 µM 0.521419749777229 0.306281129884684 no 1047 0.301037198138495 1482 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_167 3672-0051 66.205 µM 0.521390924087686 0.306291178544262 no 1048 0.301047236327215 1401 3237971
SGTC_375 3970-0961 9.27 µM 0.520922886434615 0.306454357248415 no 1049 0.301210245740305 1471 2898222
SGTC_1048 3161-0300 24.5 µM 0.519493757358594 0.306952852538072 no 1050 0.301708232532814 1423 2165101
SGTC_3021 9087658 49.47 µM 0.519373968922074 0.306994652241051 no 1051 0.301749990190625 1448 25237042
SGTC_1214 0358-0031 63.7 µM 0.518767338857684 0.307206371925919 no 1052 0.301961498321137 1644 4301366
SGTC_142 0335-0849 62.6745 µM 0.518598201532277 0.307265413930198 no 1053 0.302020481748908 1493 3889043 YPR107C YTH1
SGTC_1356 1502-0781 85.8 µM 0.516965398524162 0.307835645158651 no 1054 0.302590156646533 1442 567702
SGTC_74 000s-0487 160.283 µM 0.516746447802994 0.307912145658614 no 1055 0.302666583806479 1363 677548
SGTC_2935 9038016 29.96 µM 0.513788949461232 0.308946300633986 no 1056 0.303699777372166 1444 6463195
SGTC_760 0568-0725 82.9 µM 0.513089185205487 0.309191210878491 no 1057 0.303944468109028 1548 3916171
SGTC_1173 0443-0020 122 µM 0.511090323039798 0.309891258819557 no 1058 0.304643905836869 1462 5331295
SGTC_2082 5219693 150 µM 0.509550686349102 0.310430945871697 no 1059 0.305183139849511 1441 2834649
SGTC_2511 berberine 10.47 µM 0.509256927956129 0.310533963084447 no 1060 0.30528607230299 1460 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1842 st055362 61.2 µM 0.509142759403643 0.310574004507984 no 1061 0.305326080930276 1502 676032
SGTC_1720 st037298 9.481 µM 0.509056340158769 0.310604315131175 no 1062 0.305356366782597 1459 597396
SGTC_3099 9120367 49.47 µM 0.508674270790332 0.310738337270125 no 1063 0.305490279965021 1459 24824940
SGTC_2543 pimpinellin 60.67 µM 0.508557613009085 0.310779263445679 no 1064 0.305531173054214 1414 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3218 9131285 49.47 µM 0.507359422870229 0.311199750957944 no 1065 0.305951325652309 1612 17156417
SGTC_63 0099-0242 26.702 µM 0.507162855363243 0.311268757035503 no 1066 0.306020277641479 1465 3898502 YLR359W ADE13
SGTC_1164 k060-0068 93.7 µM 0.506093092589207 0.311644419221033 no 1067 0.306395649694574 1499 5963676
SGTC_94 0334-0113 514.748 µM 0.505658739343646 0.311797004452302 no 1068 0.306548119163566 1405 6795178
SGTC_859 0439-0102 54.6 µM 0.50561305770642 0.311813053967517 no 1069 0.306564156572341 1509 610143
SGTC_2667 digitoxin 100 µM 0.502860228210589 0.312780875510575 no 1070 0.307531272628098 1479 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1036 k216-0215 33.5 µM 0.502842538925938 0.312787098776751 no 1071 0.307537491514024 1445 622330
SGTC_1545 lovastatin 49.4 µM 0.500138247621995 0.313739122108928 no 1072 0.308488868214095 1524 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1716 st033144 30.6155 µM 0.499107469194866 0.314102326288035 no 1073 0.30885183795904 1562 674617
SGTC_1130 3454-2858 15.9 µM 0.498974953000433 0.314149032651547 no 1074 0.308898514666056 1451 715628 YIL048W NEO1
SGTC_1370 2001-0092 44.6 µM 0.496880702106008 0.314887562498451 no 1075 0.309636590421329 1651 790957
SGTC_734 2023-0417 80 µM 0.495870365438343 0.315244119110827 no 1076 0.309992937782261 1516 3935732
SGTC_453 enantio-paf c16 10 µM 0.494982895652411 0.315557456985285 no 1077 0.310306097125759 1472 13871343 A lipid and platelet activating factor
SGTC_387 norethindrone acetate 66.7 µM 0.494703114571705 0.315656266462761 no 1078 0.310404851342813 1475 541197
SGTC_125 0133-0007 11.75 µM 0.494197964163725 0.315834702350369 no 1079 0.31058318869852 1603 26541
SGTC_2141 5621638 7.665 µM 0.493631108922985 0.316034985544511 no 1080 0.31078336322847 1576 2856238
SGTC_635 k038-0028 24.7 µM 0.490975713423724 0.31697391703922 no 1081 0.311721812504266 1549 4035102
SGTC_1668 st014914 51.6 µM 0.490779846776173 0.317043221073789 no 1082 0.311791082719979 1488 2839556
SGTC_3192 9110362 49.47 µM 0.49040876367261 0.317174540026704 no 1083 0.31192233826031 1551 16649480
SGTC_2148 5546263 113.568 µM 0.490277115681112 0.317221133174607 no 1084 0.311968909119043 1508 792097
SGTC_1146 3579-1023 7 µM 0.4897234757492 0.317417110347477 no 1085 0.31216479374547 1597 X1146
SGTC_1119 parthenolide 318.541 nM 0.489692733440447 0.317427993994531 no 1086 0.312175672309977 1604 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1285 0929-0069 65.5 µM 0.487294304661592 0.318277591541447 no 1087 0.313024891605603 1508 1206237
SGTC_2964 9083345 53.42 µM 0.485917713231336 0.318765655247181 no 1088 0.313512754517044 1450 17741579
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.485829491020648 0.318796944729929 no 1089 0.313544031536997 1544 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1560 lithocholic acid 53.1 µM 0.485282826682247 0.318990857175262 no 1090 0.313737867846743 1508 9903 A bile acid which acts as a detergent.
SGTC_2093 5331342 194.4 µM 0.484053395633672 0.319427141186177 no 1091 0.314173987486509 1550 33839
SGTC_1783 st039459 87.517 µM 0.483136665644175 0.319752620851878 no 1092 0.314499350766349 1648 729761
SGTC_1310 1188-0297 994 nM 0.482756360400045 0.319887686786461 no 1093 0.314634369967524 1488 1588352
SGTC_3274 9138298 49.47 µM 0.480760836833843 0.320596790829604 no 1094 0.315343243686921 1478 17015756
SGTC_1644 st010134 20.9 µM 0.47838323067674 0.321442522341821 no 1095 0.3161887334509 1497 3818134
SGTC_3356 9151811 4.48 µM 0.475721995964564 0.32239024145814 no 1096 0.317136224142284 1486 1859254 YPR165W RHO1
SGTC_1297 1068-0111 14.1 µM 0.474791768629617 0.322721786954157 no 1097 0.317467700301538 1462 767057
SGTC_1496 4469-0713 57.4 µM 0.471359462846281 0.323946324856881 no 1098 0.31869202948914 1593 746691
SGTC_767 0929-0023 86 µM 0.469377230075259 0.324654392635489 no 1099 0.319400010518829 1523 1204563
SGTC_1895 st058434 18.3 µM 0.46114271010723 0.327602587963025 no 1100 0.322348110543564 1638 5393175
SGTC_2900 5328528 85.29 µM 0.459688368991716 0.328124409435712 no 1101 0.322869959608422 1476 795359
SGTC_3331 9141060 1.957 µM 0.459194556764384 0.328301666956959 no 1102 0.323047229532933 1493 4906567 YPR165W RHO1
SGTC_2620 irigenin 100 µM 0.458417213859785 0.328580778215835 no 1103 0.323326363433879 1652 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3172 9105863 49.47 µM 0.455994983220673 0.329451112659411 no 1104 0.324196792884671 1576 2348785
SGTC_37 0566-0070 1.56 µM 0.454690449967651 0.329920229442738 no 1105 0.32466597617877 1641 1626686
SGTC_1437 4092-1038 11.6 µM 0.452243544017689 0.330800870561213 no 1106 0.325546771028222 1507 3977136
SGTC_2047 4141938 200 µM 0.450151337251456 0.331554599086974 no 1107 0.326300660986367 1567 3807862
SGTC_2988 9073640 71.4286 µM 0.45001079324369 0.331605255307391 no 1108 0.326351329042007 1585 9102229
SGTC_3335 9143315 29.6265 µM 0.449966008377994 0.331621397745708 no 1109 0.326367475277876 1533 4899691
SGTC_73 0327-0325 16.231 µM 0.449797624070734 0.331682093665115 no 1110 0.32642818558887 1656 53298
SGTC_2035 5154463 94.595 µM 0.449121080574246 0.3319260055177 no 1111 0.326672157070229 1622 2769623
SGTC_288 1315-0019 35.1 µM 0.448727128250031 0.332068068596642 no 1112 0.326814256203168 1556 6811474
SGTC_1994 st072947 40.9 µM 0.447388744283182 0.332550883227579 no 1113 0.327297200645242 1599 5286565 YDL195W SEC31
SGTC_411 enrofloxacin 100 µM 0.445309552919335 0.333301491074905 no 1114 0.32804803260473 1723 71188 A bacterial gyrase inhibitor.
SGTC_274 sirtinol 40.1 µM 0.445269094221643 0.333316103685389 no 1115 0.32806264984715 1513 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2027 5150920 200 µM 0.445215071168597 0.333335615776347 no 1116 0.328082168139094 1614 786715
SGTC_3091 9116372 49.47 µM 0.444884959280182 0.333454855657587 no 1117 0.32820144631263 1559 17169793
SGTC_629 3448-6466 76.7 µM 0.444007387330975 0.333771925674933 no 1118 0.32851862147563 1564 573744
SGTC_961 1252-1571 372 µM 0.442926266774835 0.334162701792246 no 1119 0.328909533818781 1676 6813498
SGTC_973 1325-0077 65.9 µM 0.440401647235799 0.335075937129981 no 1120 0.329823116041591 1686 2835149
SGTC_713 1488-1073 324 µM 0.440214198873228 0.335143782158472 no 1121 0.32989098843264 1591 3312542
SGTC_648 0375-0473 33.3 µM 0.438143725942841 0.335893526169951 no 1122 0.330641049458525 1597 1713139
SGTC_2281 7943571 200 µM 0.436911860632828 0.336339910226443 no 1123 0.331087634990323 1675 1244024
SGTC_3290 9121031 71.43 µM 0.436653480061771 0.336433567434434 no 1124 0.331181335674749 1535 17014854
SGTC_1051 3253-3903 78 µM 0.436176664995462 0.336606428931182 no 1125 0.331354278511314 1530 5509239
SGTC_182 3448-4371 550.524 µM 0.434248847764337 0.337305679249383 no 1126 0.332053872354871 1715 3491403
SGTC_1899 st063254 59.6 µM 0.434154289200433 0.337339991648078 no 1127 0.332088202208089 1502 3093813
SGTC_2174 5790901 200 µM 0.434128434618582 0.337349373717295 no 1128 0.332097589059637 1576 786020
SGTC_1060 3448-7350 82 µM 0.430894680375242 0.338523628975756 no 1129 0.333272475804529 1685 570178
SGTC_1312 1218-2183 165 µM 0.429392614145846 0.339069601277244 no 1130 0.333818763928987 1586 6744073
SGTC_3255 9139072 49.47 µM 0.428966853625637 0.339224418628714 no 1131 0.333973673396809 1580 17646060
SGTC_1263 0774-1208 64.8 µM 0.428729807308247 0.339310626463972 no 1132 0.334059933015752 1711 906585
SGTC_740 k014-0057 261 µM 0.42827173181916 0.339477240926997 no 1133 0.334226648554418 1702 4012779
SGTC_1996 st072960 66.8 µM 0.428181377058819 0.339510109107147 no 1134 0.334259536828356 1640 1719405
SGTC_2646 retinol 96.75 µM 0.426651965324088 0.340066645356934 no 1135 0.334816421037394 1600 445354 A vitamin A analog and teratogen.
SGTC_3085 9117376 49.47 µM 0.426259564857538 0.340209491859666 no 1136 0.334959359201573 1629 16480349
SGTC_1614 st002383 48.6 µM 0.42538646740805 0.340527409927645 no 1137 0.335277484713294 1590 1947235
SGTC_206 4546-0025 72.014 µM 0.42469618213037 0.340778841453267 no 1138 0.335529083661578 1585 6620745 YIL048W NEO1
SGTC_1421 4029-0249 71.4 µM 0.424389619891025 0.340890527273602 no 1139 0.335640844802737 1705 2894095
SGTC_2561 acetosyringone 100 µM 0.422641643171738 0.341527611036038 no 1140 0.336278369396593 1570 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_645 0845-0943 5.41 µM 0.422455157379349 0.341595606073958 no 1141 0.336346412606711 1587 1885106
SGTC_1019 4262-0212 3.4 µM 0.422420693895909 0.341608172451259 no 1142 0.336358987910561 1608 4677213
SGTC_2473 5854593 8.94 µM 0.422350333779214 0.341633828318568 no 1143 0.336384662025509 1584 2872951
SGTC_3073 9114972 49.47 µM 0.42148893176785 0.341947986217962 no 1144 0.336699045865821 1700 41905075
SGTC_814 3342-0569 96 µM 0.420201497821343 0.342417724242618 no 1145 0.337169130330243 1610 4346283
SGTC_116 0155-0182 31.788 µM 0.420106816416806 0.342452279693821 no 1146 0.337203711673615 1568 771486
SGTC_1731 st035964 63 µM 0.420088108071362 0.342459107751517 no 1147 0.337210544854123 1572 6739575
SGTC_3107 9121808 49.47 µM 0.41973240883526 0.342588938480443 no 1148 0.337340473403767 1627 662681
SGTC_1327 1436-0082 2.18 µM 0.419426909394709 0.342700461059715 no 1149 0.337452080637448 1596 15992205
SGTC_3090 9117696 49.47 µM 0.419151917835836 0.34280085846179 no 1150 0.33755255474522 1700 7923821
SGTC_986 1493-0483 84 µM 0.418782642550232 0.342935695626074 no 1151 0.337687495667312 1669 40079
SGTC_2629 bisabolol 100 µM 0.418245728287353 0.34313178016827 no 1152 0.337883732609437 1682 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_847 0342-0274 5.54 µM 0.417948592963344 0.343240314062632 no 1153 0.337992351628029 1712 18097
SGTC_2 0422-0095 29 µM 0.417921965981484 0.343250040666725 no 1154 0.338002085887578 1565 6790840
SGTC_2161 5662504 8.5105 µM 0.417470631752823 0.343414924913723 no 1155 0.33816710057907 1574 2859334
SGTC_2293 7624732 200 µM 0.417055013418719 0.34356678756819 no 1156 0.338319084495507 1519 894453
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.416847573914949 0.343642593273206 no 1157 0.338394951132597 1600 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1712 st032288 53.4 µM 0.416282590023031 0.343849090176392 no 1158 0.338601615371675 1580 2883011
SGTC_2752 diclazuril 33.15 µM 0.413590537982866 0.344833651717969 no 1159 0.339587001982771 1656 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2450 5739737 12.93 µM 0.413438181688729 0.344889404341365 no 1160 0.339642802672014 1605 2262825
SGTC_2649 anisomycin 9.56 µM 0.412225425190382 0.34533331538941 no 1161 0.340087101562384 1602 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_926 2268-1401 59.4 µM 0.411913889766183 0.345447382573168 no 1162 0.340201269878337 1584 2931578
SGTC_39 0986-0283 58.349 µM 0.41189063040456 0.345455899438816 no 1163 0.340209794319193 1751 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2371 9071574 200 µM 0.411831019782775 0.345477727379489 no 1164 0.340231641689738 1622 45596039
SGTC_342 k048-0088 23.3 µM 0.410979035878682 0.345789759014912 no 1165 0.340543953483552 1559 6820570
SGTC_1590 st077108 57.8 µM 0.406991355066116 0.347251601997288 no 1166 0.342007168794309 1717 5489485
SGTC_2159 5658611 73.75 µM 0.405395262587501 0.347837352073183 no 1167 0.342593496346629 1701 793844
SGTC_2772 vinpocetine 57.06 µM 0.404980127144826 0.34798976225417 no 1168 0.342746059367399 1664 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2306 7482397 179.52 µM 0.40409248753235 0.348315726980063 no 1169 0.343072354552086 1742 891448
SGTC_1423 4048-0112 5.59 µM 0.403823276855457 0.348414610415729 no 1170 0.343171339197128 1700 X1423
SGTC_971 1315-0384 26.7 µM 0.401062086514256 0.349429413472997 no 1171 0.344187206785592 1583 6769120
SGTC_1565 sinapyl alcohol 95.1 µM 0.398777260577744 0.350269956181709 no 1172 0.345028666833498 1557 5280507 A phenol propionate derived from cinnamic acid.
SGTC_62 0180-0423 3.232 µM 0.39698586226851 0.350929490076113 no 1173 0.345688943050453 1677 30102 YGL099W LSG1
SGTC_1794 st048918 76.9 µM 0.396412372572484 0.351140725162159 no 1174 0.345900420068306 1735 672303
SGTC_1223 0764-0573 147 µM 0.395446762603453 0.351496494927185 no 1175 0.346256601883281 1614 1609797
SGTC_1073 triclabendazole 3.09 µM 0.393506114567118 0.352211901460712 no 1176 0.346972854369813 1666 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2006 4011487 200 µM 0.392554808166991 0.352562785315402 no 1177 0.347324161607306 1757 45595294
SGTC_2881 9058953 51.95 µM 0.391597659066233 0.352915950870276 no 1178 0.347677758918799 1557 17122249
SGTC_1722 st034304 3.6505 µM 0.390125541416715 0.353459375060961 no 1179 0.348221858463153 1594 4036148 YLR033W RSC58
SGTC_2460 5552655 174.22 µM 0.387840516025448 0.354303471344564 no 1180 0.349067030160851 1589 5401989
SGTC_1620 st003704 16.5 µM 0.386483765579072 0.354804998836793 no 1181 0.349569211798336 1701 2834414
SGTC_1926 methyl fluorone black 53.6 µM 0.38617372385466 0.354919642200236 no 1182 0.349684006278115 1569 72721 Reacts with homocysteine.
SGTC_2886 9058944 51.95 µM 0.383605957399455 0.355869622970351 no 1183 0.35063526193362 1629 4949929
SGTC_2240 6690706 185.951 µM 0.38209008651033 0.356430861267586 no 1184 0.351197272402835 1565 805876
SGTC_2576 guaiol 23.12 µM 0.381485627945558 0.356654743728341 no 1185 0.351421466816349 1822 227829
SGTC_2343 7990716 14.84 µM 0.380978346151222 0.356842671484667 no 1186 0.351609658154279 1693 6456862
SGTC_2175 5807670 165.306 µM 0.380108611501551 0.357164954466722 no 1187 0.351932396827639 1715 241186
SGTC_220 paclitaxel 373.376 µM 0.379614368223143 0.357348143345747 no 1188 0.352115846789834 1693 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2938 9059746 27.26 µM 0.379165941524764 0.357514378981844 no 1189 0.352282320640774 1692 6471769
SGTC_591 4299-0174 154 µM 0.375455345365102 0.358890963781458 no 1190 0.35366092529511 1684 5509088
SGTC_1512 0259-0544 12.2 µM 0.374990622073113 0.359063499956854 no 1191 0.353833720563291 1718 18476
SGTC_3351 9150312 21.596 µM 0.374833199009427 0.359121952382946 no 1192 0.353892261064905 1664 4904905
SGTC_2451 5856223 45.7 µM 0.372283641746039 0.360069081487529 no 1193 0.354840838369412 1618 2179896
SGTC_1250 0485-0349 40.2 µM 0.370454215619246 0.360749220866301 no 1194 0.355522042158211 1637 6842794 YDL195W SEC31
SGTC_25 0118-0223 35.662 µM 0.370269745552385 0.360817827170506 no 1195 0.35559075696322 1718 5333628
SGTC_2971 9092186 9.93 µM 0.37016742647638 0.3608558826125 no 1196 0.355628872679295 1548 25236400
SGTC_2761 levamisole 97.89 µM 0.369288983945606 0.361182657604364 no 1197 0.355956167859088 1789 26879 An alkaline phosphatase inhibitor.
SGTC_328 k915-0120 63.5 µM 0.368503934759337 0.361474776618333 no 1198 0.356248755871702 1777 6624543
SGTC_3177 9107506 49.47 µM 0.366564709249545 0.362196713759758 no 1199 0.356971868177344 1766 8897194
SGTC_49 0717-0965 32.132 µM 0.364155824762751 0.363094178929821 no 1200 0.357870826115236 1753 5889349 YGL099W LSG1
SGTC_2731 amoxapine 43.43 µM 0.363773806232785 0.363236574760361 no 1201 0.358013462037173 1780 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_306 1672-3436 11.6 µM 0.360825832505704 0.364336054257686 no 1202 0.359114825181627 1731 6797378
SGTC_1290 0986-0249 10.2 µM 0.359827353758324 0.36470870173281 no 1203 0.359488123048579 1729 53329
SGTC_1322 1348-1070 12 µM 0.359490198358739 0.364834562157536 no 1204 0.359614204507257 1729 6758089
SGTC_439 amiodarone 34.4 µM 0.359442594727169 0.364852333811427 no 1205 0.359632007426983 1754 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_160 3453-0671 289.699 µM 0.358662142785559 0.36514373787226 no 1206 0.359923926117729 1618 5322268
SGTC_541 4513-1321 94 µM 0.358229969580308 0.365305135621704 no 1207 0.360085610490471 1643 747515
SGTC_1393 3470-5649 58.2 µM 0.357565859165032 0.365553198245058 no 1208 0.360334115850773 1675 4108395
SGTC_3220 9131269 49.47 µM 0.356860291936114 0.365816807691542 no 1209 0.360598198710727 1686 17722206
SGTC_2364 9055074 200 µM 0.356121158484706 0.366093025895174 no 1210 0.360874916207012 1633 6470630
SGTC_3005 9076496 71.4286 µM 0.355130484067698 0.366463355172612 no 1211 0.361245920082716 1745 21368410
SGTC_430 0958-0115 16.4 µM 0.354714113283986 0.366619038093315 no 1212 0.361401888371836 1687 6833180
SGTC_1906 st060206 94.7 µM 0.353350218313104 0.367129158166082 no 1213 0.361912950848577 1804 5133468
SGTC_3138 9097216 49.47 µM 0.353197002833571 0.367186478055875 no 1214 0.361970377335269 1743 25237486
SGTC_1765 st044815 90.4 µM 0.352731533033798 0.367360634472332 no 1215 0.362144858498605 1621 645695
SGTC_1960 st011366 51.8 µM 0.351126997862569 0.367961183335708 no 1216 0.362746537239307 1685 3972846
SGTC_2315 7733312 200 µM 0.349616608837793 0.368526790047486 no 1217 0.363313222306321 1663 726316
SGTC_2268 7933382 153.85 µM 0.349488448775732 0.368574796240892 no 1218 0.363361320659956 1683 935025 YOR257W CDC31
SGTC_688 0527-0193 473 µM 0.345960507869521 0.369897095306618 no 1219 0.36468619715334 1748 4007154
SGTC_2891 9063876 19.48 µM 0.343964576062481 0.370645868713433 no 1220 0.365436463321429 1859 6472478
SGTC_904 1141-0088 396 µM 0.343732348322973 0.370733020793158 no 1221 0.365523790706974 1641 1378119
SGTC_2214 7179297 48.276 µM 0.342528622461168 0.371184869810877 no 1222 0.365976553819789 1772 769744
SGTC_1039 k821-0043 94 µM 0.34244747338951 0.371215337569916 no 1223 0.366007083529218 1804 15992768
SGTC_1224 0823-0416 294 µM 0.341599345524157 0.371533818999425 no 1224 0.36632621490141 1790 3598164
SGTC_2414 st077232 92.9 µM 0.341550446379587 0.371552183855069 no 1225 0.366344617367179 1619 729801
SGTC_990 3985-0011 41.3 µM 0.34143019305158 0.371597348158771 no 1226 0.366389874225844 1708 5399565 YGL099W LSG1
SGTC_3289 9119912 71.43 µM 0.341387183673338 0.371613501892422 no 1227 0.366406061084372 1742 17014829
SGTC_1114 scopoletin 1.73284 µM 0.339876410261009 0.372181070962295 no 1228 0.366974801071155 1826 5280460 A coumarin with genotoxic properties.
SGTC_2851 9015922 71.43 µM 0.337916309943518 0.372917857547189 no 1229 0.367713128123624 1797 2996893
SGTC_431 k089-0097 107 µM 0.337054264916207 0.373242041037937 no 1230 0.368037996721031 1718 5499420
SGTC_1696 st025591 34.7925 µM 0.336476033162645 0.373459543082338 no 1231 0.368255960918535 1711 2787147
SGTC_1613 st002381 52.1 µM 0.334659354314986 0.37414314939777 no 1232 0.368941032828173 1722 551167
SGTC_2157 5649910 96.377 µM 0.333634933939086 0.374528807918381 no 1233 0.369327526894538 1675 2858091
SGTC_3257 9139206 32.98 µM 0.333409385045265 0.374613736083614 no 1234 0.369412639905057 1801 4910041
SGTC_2356 9061756 188.97 µM 0.332200069878894 0.37506919517761 no 1235 0.369869095498633 1854 20104043
SGTC_3193 9111931 49.47 µM 0.331974353976214 0.375154224890129 no 1236 0.369954312217674 1731 17087244
SGTC_547 1120-0019 610 nM 0.331494551597577 0.375334991980046 no 1237 0.37013547788335 1728 3676939
SGTC_3142 9086498 49.47 µM 0.331457794980325 0.375348841283381 no 1238 0.370149357780022 1868 25236367
SGTC_2983 9022671 12.99 µM 0.331365288579614 0.375383696921133 no 1239 0.370184290450231 1881 6405161
SGTC_978 1416-0512 87.4 µM 0.330317816319149 0.37577844662139 no 1240 0.370579916137258 1756 6814003
SGTC_2654 protoveratrine a 100 µM 0.3302977577548 0.375786007148963 no 1241 0.37058749350641 1764 5702278 A heart drug and vasodilator.
SGTC_2087 5276107 200 µM 0.329006423674795 0.376272840475621 no 1242 0.371075416350961 1698 144405
SGTC_2349 9023730 187.07 µM 0.32880337437972 0.376349408055036 no 1243 0.371152156193383 1834 4126287
SGTC_1365 1672-3266 55.4 µM 0.328113880068678 0.376609444817345 no 1244 0.371412779829803 1840 6415873
SGTC_1075 aripiprazole 15.2 µM 0.327095571901851 0.376993593252707 no 1245 0.371797800441291 1718 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1339 1486-1321 22.7 µM 0.325895452198416 0.377446484933193 no 1246 0.372251728324174 1716 3469382
SGTC_2899 9053889 58.44 µM 0.325855966568635 0.377461388575661 no 1247 0.372266666211819 1869 6470052
SGTC_3189 9110682 49.47 µM 0.325277915210619 0.37767959188735 no 1248 0.372485371970176 1729 17122418
SGTC_1635 st007035 42.4 µM 0.323772422877748 0.378248069490273 no 1249 0.373055167937562 1717 3716403
SGTC_2927 9011802 47.9 µM 0.322916852050277 0.378571252714683 no 1250 0.373379106683715 1671 43912568
SGTC_1907 st060210 83.7 µM 0.321711051260426 0.37902687594198 no 1251 0.373835802450901 1829 688793
SGTC_3185 9108267 49.47 µM 0.32147921714896 0.379114495942341 no 1252 0.373923629701936 1686 4910486
SGTC_2786 7743617 45.45 µM 0.319253988587076 0.379955820053067 no 1253 0.374766960102371 1664 583674
SGTC_2601 securinine 100 µM 0.318972712518288 0.380062206684581 no 1254 0.374873602529628 1694 442872 A GABA receptor antagonist.
SGTC_1678 st019265 80.2 µM 0.317646551124625 0.38056392089432 no 1255 0.37537652939774 1906 5367020
SGTC_861 0443-0273 110 µM 0.317584195793036 0.380587516155387 no 1256 0.375400181946593 1810 6149169
SGTC_2051 5263410 176 µM 0.316373080340467 0.381045890315175 no 1257 0.375859673591623 1822 227584
SGTC_3007 9078383 71.4286 µM 0.315179755734184 0.381497694442012 no 1258 0.376312587707491 1729 6496995
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.314895101113996 0.381605491290624 no 1259 0.376420650639314 1750 688667
SGTC_610 4215-0184 155 µM 0.314310339677875 0.381826965434702 no 1260 0.376642672973371 1769 5605015
SGTC_2716 st080858 38.6235 µM 0.313498216574465 0.382134615316321 no 1261 0.37695108771101 1840 5296050
SGTC_3277 9138724 49.47 µM 0.313320706340046 0.382201869970342 no 1262 0.377018510089393 1790 15943418
SGTC_1740 st038286 13.222 µM 0.312470226837727 0.382524146890609 no 1263 0.377341593318055 1789 716786
SGTC_2565 isoliquiritigenin 100 µM 0.312104480745397 0.382662766124334 no 1264 0.377480560683132 1642 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_10 0279-0212 42.575 µM 0.310138612991733 0.383408095026064 no 1265 0.378227774997918 1725 39851 YBR002C RER2
SGTC_1675 st018485 24.5 µM 0.309316796594594 0.383719802347877 no 1266 0.378540277609048 1755 3323024
SGTC_855 0428-0020 25 µM 0.307812250357908 0.384290657633291 no 1267 0.379112599727341 1766 6812414
SGTC_664 1222-0054 14.9 µM 0.304295423261385 0.385625990350049 no 1268 0.380451415825088 1774 6813991
SGTC_1805 st050013 60.3 µM 0.303872796798674 0.385786552460621 no 1269 0.380612401697009 1845 4037144
SGTC_2256 7954252 200 µM 0.303490970681868 0.385931630738429 no 1270 0.380757863776617 1771 2972920
SGTC_1882 5615643 20 µM 0.30344353915507 0.385949653889446 no 1271 0.380775934667574 1822 2253075
SGTC_2338 7999974 200 µM 0.302836727267475 0.38618025350666 no 1272 0.381007146270359 1949 315925
SGTC_1082 camptothecin 424.86 nM 0.30224646190687 0.386404603726582 no 1273 0.381232093973544 1531 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_631 k072-0230 41.5 µM 0.302077942532018 0.386468662160443 no 1274 0.381296323382868 1827 5773147
SGTC_3126 9127922 49.47 µM 0.301228986734411 0.386791418538487 no 1275 0.381619943760226 1809 45595682
SGTC_857 0438-0306 1.35 µM 0.300418583284852 0.387099591132442 no 1276 0.381928945274248 1802 4686136
SGTC_3003 9075612 71.4286 µM 0.298989940707421 0.387643035114064 no 1277 0.382473860423417 1788 6501993
SGTC_3272 9137413 49.47 µM 0.298136509362283 0.387967778562652 no 1278 0.382799488720962 1696 17614870
SGTC_1703 st026983 48.3 µM 0.297977213310861 0.388028401788725 no 1279 0.382860277605313 1896 1104023
SGTC_1857 st056007 79.3 µM 0.297657994560535 0.388149894935869 no 1280 0.382982103192154 1906 619834
SGTC_3006 9075424 71.4286 µM 0.296551417992055 0.388571137423743 no 1281 0.383404502955839 1734 7465181
SGTC_3098 9119039 49.47 µM 0.2959288699444 0.38880818155275 no 1282 0.383642201476541 1777 17161528
SGTC_310 1273-0058 1.06 µM 0.295395671136506 0.389011237593451 no 1283 0.383845819889887 1828 2734232
SGTC_605 1315-0399 119 µM 0.295073348576993 0.389134001155427 no 1284 0.383968924260446 1834 24020461
SGTC_536 3852-0578 10.6 µM 0.294882151780551 0.389206827847466 no 1285 0.384041953417589 1903 2869208
SGTC_1299 1079-1439 3.74 µM 0.294488962733555 0.389356605439982 no 1286 0.384192148080263 1744 323161
SGTC_2123 5259487 200 µM 0.294059865103158 0.389520080456184 no 1287 0.384356079343632 1877 2173474
SGTC_1870 st057514 26.5 µM 0.293151871845328 0.389866066652937 no 1288 0.38470303472429 1768 5393161
SGTC_3010 9080089 71.4286 µM 0.292130875942218 0.390255216174446 no 1289 0.385093280114044 1886 17027233
SGTC_2418 pentamidine 31.67 µM 0.292017365130618 0.39029848728027 no 1290 0.385136673451268 1821 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1815 st051655 58.2 µM 0.291038363391489 0.390671745863428 no 1291 0.385510989541456 1915 5984156
SGTC_455 paf C-16 10 µM 0.2902611037499 0.390968159128334 no 1292 0.38580824659468 1783 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_513 4245-1575 41.7 µM 0.289170413502143 0.391384208082165 no 1293 0.386225485862344 1881 719745
SGTC_3088 9117578 49.47 µM 0.289109854385786 0.391407312290113 no 1294 0.386248656375276 1879 678341
SGTC_957 1187-1561 14.1 µM 0.287890021732717 0.391872778154968 no 1295 0.386715462612287 1840 1538454
SGTC_1078 idebenone 36.1 µM 0.28782575186882 0.391897306660223 no 1296 0.386740061991979 1814 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.286712694293318 0.392322171631123 no 1297 0.387166158427928 1828 4000243
SGTC_322 k048-0136 19.3 µM 0.284486073623719 0.393172479371074 no 1298 0.38801895249236 1846 6823282
SGTC_2158 5657123 3.6195 µM 0.281756987540539 0.394215365066306 no 1299 0.389064927075122 1883 2858827
SGTC_906 1165-0455 526 µM 0.281516271042669 0.394307388355994 no 1300 0.389157225008663 1764 3252859
SGTC_2187 6125751 200 µM 0.280248869975865 0.394791999142168 no 1301 0.389643287682721 1837 874498
SGTC_2270 7924575 90.91 µM 0.280047207983781 0.394869122819908 no 1302 0.389720643284277 1955 1262135
SGTC_1733 st037357 54.9 µM 0.278227668306563 0.395565174096154 no 1303 0.390418798401035 1690 1272339 YGL099W LSG1
SGTC_2753 fluvastatin 17.09 µM 0.277948580181397 0.395671966700784 no 1304 0.390525915493061 1830 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_719 2810-4230 27.3 µM 0.277843413716435 0.395712210505226 no 1305 0.390566281695 1832 721079
SGTC_1845 st056753 3.01 µM 0.276915452431173 0.396067359416312 no 1306 0.390922513541175 1731 5375839
SGTC_106 0092-0003 11.579 µM 0.274665344900309 0.396928877247378 no 1307 0.391786679113808 1926 1072148
SGTC_3205 9113483 49.47 µM 0.27437022303042 0.397041910493838 no 1308 0.39190006192986 1920 17018033
SGTC_1648 st011736 69.8 µM 0.273258090339809 0.397467940868159 no 1309 0.392327414394434 1908 2855514
SGTC_3233 9132340 49.47 µM 0.272496081771549 0.397759918060245 no 1310 0.392620301811305 1789 17682950
SGTC_1500 4488-1866 171 µM 0.269787836657147 0.398798093028381 no 1311 0.393661740455 1924 2900003
SGTC_1441 4106-0040 13 µM 0.268972366383121 0.399110834962553 no 1312 0.393975473858464 1853 2904180
SGTC_561 1550-0330 72.9 µM 0.268434149672841 0.399317282561219 no 1313 0.394182578052909 1796 6812934
SGTC_1670 st016595 4.04 µM 0.267221590407569 0.399782495616535 no 1314 0.394649276826973 1945 597879
SGTC_1052 3253-3998 198 µM 0.266896517638284 0.399907237937917 no 1315 0.394774418972607 1851 5450317
SGTC_2389 9091542 195.52 µM 0.266362813678477 0.400112061831805 no 1316 0.394979900691191 1812 3626624 YOL127W RPL25
SGTC_272 doxorubicin 8.13 µM 0.265367169955376 0.400494241504298 no 1317 0.395363312188274 1893 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_465 cgp-37157 41 µM 0.265107336958367 0.400593994570626 no 1318 0.395463387715113 1936 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3238 9133470 49.47 µM 0.263392716833998 0.401252420479633 no 1319 0.396123951802423 1951 3534688
SGTC_2344 7990960 76.95 µM 0.26251996020269 0.401587672877266 no 1320 0.39646029940726 1817 140813
SGTC_1669 st015249 58.4 µM 0.26230039494659 0.401672025993173 no 1321 0.396544928779581 1992 722793
SGTC_1751 st044839 27.194 µM 0.261639702843509 0.401925879918131 no 1322 0.396799615749774 1945 5291326
SGTC_1184 1269-1718 139 µM 0.26145138658907 0.401998243171972 no 1323 0.396872216930374 1950 5403821
SGTC_2703 st077852 53.4 µM 0.260253618652432 0.402458581425274 no 1324 0.397334073527909 1849 6281836
SGTC_1963 st076565 50.3 µM 0.259247015403708 0.402845553994519 no 1325 0.397722328836704 1809 4914280
SGTC_3321 9137793 26.8275 µM 0.259110434158199 0.402898067819245 no 1326 0.397775017183261 1924 4904192
SGTC_2122 5258151 111.688 µM 0.258002105344352 0.403324271444928 no 1327 0.398202641195493 1828 2173356
SGTC_566 0958-0068 16.5 µM 0.255990357743213 0.404098174446921 no 1328 0.398979141359955 1904 6815365
SGTC_510 ag-490 170 µM 0.255508220769841 0.40428370452707 no 1329 0.399165297513943 1998 5328779
SGTC_3048 9093155 49.47 µM 0.254603734368518 0.404631816018585 no 1330 0.39951458730668 1978 25236002
SGTC_1105 epirubicin 18.1 µM 0.254469315356282 0.404683556583465 no 1331 0.399566503405071 1811 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.254069396566073 0.404837503172764 no 1332 0.39972097288098 1822 2333 A French combination drug.
SGTC_3348 9149464 3.537 µM 0.253231222527844 0.405160201525744 no 1333 0.400044770264741 1929 1951442
SGTC_1433 4060-0023 7.6 µM 0.252737841713237 0.40535018410132 no 1334 0.400235401754198 1919 3840627
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.251379588343736 0.405873311971876 no 1335 0.400760323640274 1829 442882
SGTC_2521 angolensin 13.4 µM 0.250661919503289 0.406149788267669 no 1336 0.401037752343506 1886 821428 A flavenoid.
SGTC_1662 st014054 52 µM 0.250181274803772 0.406334979050764 no 1337 0.401223582718704 1949 2838777
SGTC_992 3909-8734 162 µM 0.249989087348841 0.406409034096438 no 1338 0.401297893897105 1818 4288319
SGTC_2875 9039966 71.43 µM 0.249415197810156 0.4066301892352 no 1339 0.401519815196193 1964 6463691
SGTC_58 0957-0393 9 µM 0.249359312875887 0.406651726749758 no 1340 0.401541427424866 1843 6997992
SGTC_3231 9132313 49.47 µM 0.248757026772672 0.406883859910872 no 1341 0.401774366992504 1885 4905967
SGTC_2057 5236571 38.335 µM 0.247404371882777 0.407405319409906 no 1342 0.402297645532686 1967 54684039 YBR257W POP4
SGTC_1305 1181-0477 144 µM 0.246836464026222 0.407624301497877 no 1343 0.402517394620355 1987 6252086
SGTC_2058 5236698 133 µM 0.246716013924713 0.407670750095034 no 1344 0.402564006143203 1848 766665
SGTC_758 0868-0029 16 µM 0.245140850377721 0.408278292125577 no 1345 0.403173686831329 1991 762687
SGTC_3241 9133421 49.47 µM 0.245116619285475 0.408287639806344 no 1346 0.403183067527984 1922 17018221
SGTC_689 0833-0039 98 µM 0.244532931387908 0.408512826104775 no 1347 0.403409050191481 1967 5374726
SGTC_1831 st055328 12 µM 0.244293768439803 0.408605103697971 no 1348 0.403501654681852 1977 1103068
SGTC_649 1123-0311 367 µM 0.244004342137686 0.408716781461501 no 1349 0.403613728503718 1966 693629 YIL048W NEO1
SGTC_2074 5212007 75.395 µM 0.243388943431405 0.408954263258204 no 1350 0.403852054098904 2024 758611
SGTC_1371 2421-0008 32.7 µM 0.243068250453456 0.409078031638071 no 1351 0.403976263094853 1844 2827552
SGTC_313 3474-0040 5.03 µM 0.242896640518389 0.409144266571334 no 1352 0.404042734065004 1847 1043375 YIL048W NEO1
SGTC_1324 1418-0026 34.4 µM 0.242728279499309 0.409209250067058 no 1353 0.40410794930065 1901 1372513
SGTC_3129 9127257 49.47 µM 0.242373741857215 0.409346101630734 no 1354 0.404245289422366 1749 837894
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.240694299716503 0.409994516311719 no 1355 0.404896028638753 1901 6708739 YPR165W RHO1
SGTC_2512 diallyl trisulfide 49.23 µM 0.240328323509271 0.41013584854931 no 1356 0.405037869671067 1979 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_528 3492-0019 172 µM 0.240113553577115 0.410218793571868 no 1357 0.405121113648867 1921 2869262
SGTC_582 0987-0078 156 µM 0.239275898567637 0.410542337699232 no 1358 0.405445826413658 1973 1625765
SGTC_363 0455-0021 3.06 µM 0.238674105215554 0.410774817893396 no 1359 0.405679148780078 1874 4597466
SGTC_2069 5228469 200 µM 0.238386913867464 0.410885774507932 no 1360 0.405790508064778 1866 2835210
SGTC_1797 st048695 56.8 µM 0.236609403571379 0.411572675398087 no 1361 0.406479912170102 1991 592262 YIL048W NEO1
SGTC_949 1165-0505 146 µM 0.236159436511235 0.411746603706178 no 1362 0.406654477148648 1829 6244267
SGTC_3130 9127414 49.47 µM 0.234456838031648 0.41240487538276 no 1363 0.40731516882017 2007 1494646
SGTC_3134 9127454 49.47 µM 0.233557319277309 0.412752753848755 no 1364 0.407664332804646 1992 24262820
SGTC_314 1671-0008 2.74 µM 0.233486472157919 0.412780156067211 no 1365 0.407691836477007 1921 3913060
SGTC_214 4373-3496 70 µM 0.233392052257044 0.412816676416654 no 1366 0.407728492083377 1966 3779166
SGTC_898 1000-0849 28.3 µM 0.233159761563866 0.412906526548059 no 1367 0.407818675198471 2019 6751807
SGTC_2557 derrustone 83.84 µM 0.232875515277596 0.413016479330645 no 1368 0.407929035879602 1810 629853 An antioxidant.
SGTC_574 1315-0397 40 µM 0.232268796678358 0.413251194389782 no 1369 0.408164623201723 1949 6794277
SGTC_1812 st052057 4.327 µM 0.232128191689636 0.413305593241683 no 1370 0.408219224510682 1864 3645418
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.23159139074646 0.413513292173395 no 1371 0.408427697464877 1917 97141
SGTC_482 fipronil 114 µM 0.231387868386366 0.413592045341783 no 1372 0.408506744544323 1951 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_42 0133-0086 60.653 µM 0.230300717252005 0.414012778293903 no 1373 0.408929051651683 1850 162923 Model of phenazepam hydroxylation.
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.229540423754031 0.414307074383641 no 1374 0.409224452797775 1920 16486 A toxic proline analog.
SGTC_681 1642-0006 26.6 µM 0.229244852794841 0.414421497643154 no 1375 0.409339306586005 1972 4446530
SGTC_908 3448-7491 47.7 µM 0.228977907099083 0.414524845555778 no 1376 0.409443043778204 1871 1203031
SGTC_2324 6149169 200 µM 0.226789015580752 0.415372496543844 no 1377 0.410293902738035 1998 2888231
SGTC_2666 tannic acid 100 µM 0.225817437475275 0.41574886788088 no 1378 0.410671707106037 1939 16134267 A thiamine antagonist.
SGTC_2750 bromebric acid 70.15 µM 0.225332498527127 0.415936753175268 no 1379 0.410860309757227 1904 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_697 0508-1955 564 µM 0.224890235970856 0.416108120634707 no 1380 0.41103233265932 2036 6243113
SGTC_787 4152-0075 138 µM 0.224803033760532 0.416141911544816 no 1381 0.411066252941852 1900 9566539
SGTC_1457 k015-0032 57.3 µM 0.224275119222633 0.416346491979686 no 1382 0.411271617548402 1884 4302660
SGTC_918 glabranin 770.725 nM 0.223825265798648 0.416520839616689 no 1383 0.411446634707243 1929 124049 Also referred to as licorice root.
SGTC_2223 6903751 107.57 µM 0.223753343956727 0.41654871556021 no 1384 0.411474617804 1974 5598863
SGTC_1140 3229-1848 2.98 µM 0.222409824718176 0.417069522637187 no 1385 0.411997432162701 2027 2849525
SGTC_2046 4110841 106 µM 0.22190550085355 0.41726505834559 no 1386 0.412193724113018 2043 44119630 YMR134W ERG29
SGTC_3176 9106582 49.47 µM 0.220922045593724 0.417646420994448 no 1387 0.412576565796629 2029 17018027
SGTC_2781 5567276 71.43 µM 0.220660219689834 0.417747964481335 no 1388 0.412678504011773 1960 2853274
SGTC_1850 st056238 17 µM 0.220373951013938 0.417858993842235 no 1389 0.412789965414505 2023 5393177
SGTC_2834 9001755 58.44 µM 0.218504066219769 0.418584389693314 no 1390 0.413518195237589 1877 2989575
SGTC_1050 3232-1156 69.3 µM 0.215269470852024 0.419839858627394 no 1391 0.414778615184691 1879 700529
SGTC_1081 sertraline 6 µM 0.214826786361706 0.420011745025408 no 1392 0.414951183970453 2040 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2145 5634607 200 µM 0.214791102293951 0.42002560116988 no 1393 0.414965095171318 1883 308662
SGTC_1792 st045773 43.6 µM 0.213959999510773 0.42034834687466 no 1394 0.415289125291264 1907 2919270
SGTC_3195 9113082 49.47 µM 0.21391559450635 0.420365592369498 no 1395 0.415306439525502 2082 17018038
SGTC_184 1494-0393 24.714 µM 0.213696619484152 0.420450637555521 no 1396 0.415391823856708 1857 3090647
SGTC_117 lucigenin 22.078 µM 0.2133812617324 0.420573122243589 no 1397 0.415514797461541 1808 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1478 0453-0656 35.7 µM 0.212980525787899 0.420728778844733 no 1398 0.415671076189642 1996 5258496
SGTC_732 3970-1727 52.7 µM 0.212801667620623 0.420798256161523 no 1399 0.415740831481459 2053 1275699
SGTC_368 fentichlor 4.58 µM 0.212343664161736 0.420976178493072 no 1400 0.415919466482828 1890 7329 A pesticide.
SGTC_1065 prochlorperazine maleate 2.48 µM 0.211547976836327 0.421285320509749 no 1401 0.416229849547641 1971 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2949 9072542 2.23 µM 0.211232006138269 0.421408095544753 no 1402 0.41635311843928 1883 16457352
SGTC_1493 4348-0038 111 µM 0.210732858043144 0.421602062402028 no 1403 0.416547866650381 1956 800424
SGTC_980 1473-0395 201 µM 0.208738506834932 0.422377248320188 no 1404 0.417326189060813 1887 768876
SGTC_1747 st037496 66.6 µM 0.208553125682809 0.422449319587404 no 1405 0.417398553059098 1927 723305
SGTC_2470 5664817 21.68 µM 0.2081363103141 0.422611375808308 no 1406 0.417561268198671 2004 2859561
SGTC_3047 9092122 49.47 µM 0.207835853177145 0.422728200519913 no 1407 0.417678568516221 1915 17173831
SGTC_1833 st055984 71 µM 0.207319145775802 0.42292912424467 no 1408 0.41788031139443 1916 676288
SGTC_2741 miltefosine 3.04 µM 0.206585412839326 0.423214473648578 no 1409 0.418166826694471 1964 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2099 5377090 177.372 µM 0.206140070001381 0.423387687536436 no 1410 0.418340749764687 1917 2243829
SGTC_2265 7929201 200 µM 0.205933941823488 0.423467865083793 no 1411 0.41842125595174 1905 1265108
SGTC_261 5-fluorouridine 15.376 µM 0.203835966453845 0.4242840929476 no 1412 0.419240842839459 2030 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_202 3594-0513 34.79 µM 0.203821626246904 0.424289673198972 no 1413 0.419246446139089 2046 708429
SGTC_1417 3966-0327 90.4 µM 0.203718114026093 0.424329953696257 no 1414 0.419286893041711 1957 651118
SGTC_1291 0993-0025 5.79 µM 0.202853084465154 0.424666600086265 no 1415 0.419624932490248 2028 4353356
SGTC_966 1300-0360 30.2 µM 0.202835783754425 0.424673333621947 no 1416 0.419631693931821 1911 70588
SGTC_2493 resveratrol 26.09 µM 0.200959714470372 0.425403640554136 no 1417 0.420365037301313 1932 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2402 5553605 200 µM 0.199223863633524 0.426079592044832 no 1418 0.42104381654321 2013 6758546
SGTC_2020 4017018 200 µM 0.198064470738389 0.426531188232939 no 1419 0.421497311179106 1958 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_44 0929-0055 61.211 µM 0.193448388716652 0.428330152234047 no 1420 0.423303911170809 1944 1379590
SGTC_785 1270-0111 65.3 µM 0.192755793843697 0.428600197482624 no 1421 0.423575112774147 2105 6741994
SGTC_390 dec-rvkr-cmk 16.7 µM 0.190699233869509 0.429402254210627 no 1422 0.424380619480061 1993 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2628 lathosterol 100 µM 0.189906532920969 0.429711484961402 no 1423 0.424691186549997 1976 6710616
SGTC_1107 amlodipine 47 µM 0.189754366218643 0.429770849769156 no 1424 0.42475080829233 1995 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_396 dithiazanine 1.25 µM 0.189361774221236 0.429924019046715 no 1425 0.424904641081462 1917 10578 An antihelmenthic.
SGTC_168 3970-0862 530.542 µM 0.18843481631197 0.430285712328958 no 1426 0.425267904524161 1991 3135186
SGTC_1367 1812-0510 76.9 µM 0.188073351529688 0.430426769537636 no 1427 0.425409575355465 2027 1142582 YDR527W RBA50
SGTC_3332 9141069 11.198 µM 0.18734865965988 0.430709598398583 no 1428 0.425693636721448 1903 17332883
SGTC_3326 9140064 16.379 µM 0.18604497006623 0.431218484781488 no 1429 0.426204747942672 1931 1868434
SGTC_1786 berberine 21.6 µM 0.184311000915895 0.431895504689695 no 1430 0.426884742142725 2012 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2625 euphol 100 µM 0.183868323791471 0.432068377979801 no 1431 0.42705837752954 2092 6708538 A triterpene alcohol.
SGTC_2440 5628896 157.78 µM 0.182766016252845 0.432498905132556 no 1432 0.427490807263957 1967 5522048
SGTC_476 mead acid 10 µM 0.182678305858564 0.432533165542882 no 1433 0.427525219361856 1952 5312531 An omega 9 fatty acid.
SGTC_2400 5203494 178.7 µM 0.18228197580441 0.432687981682855 no 1434 0.427680721470784 2033 6777674
SGTC_1761 st044296 37 µM 0.179423830746812 0.433804747059562 no 1435 0.428802460386289 2003 1826700
SGTC_1400 3771-8998 51.5 µM 0.178473851730668 0.43417605063475 no 1436 0.429175427400726 2040 670767
SGTC_1412 3909-8563 178 µM 0.176354634516876 0.435004565054335 no 1437 0.430007671211284 2103 23767530
SGTC_805 3852-0218 479 µM 0.175906397509808 0.435179841372494 no 1438 0.430183739620018 1926 6615355
SGTC_2077 5212015 200 µM 0.173506354124727 0.436118557975317 no 1439 0.431126716880689 2104 780900
SGTC_1711 st032263 62.8 µM 0.172990837067003 0.436320236648133 no 1440 0.431329315000343 2033 3958979
SGTC_653 0203-0016 55.2 µM 0.172795389978636 0.43639670306498 no 1441 0.431406130400732 2040 295302
SGTC_200 k038-0079 37.545 µM 0.171102675223151 0.437059057311856 no 1442 0.432071516185102 2051 3436683
SGTC_1629 st005085 44.9 µM 0.170969824569359 0.437111048869671 no 1443 0.432123746358386 1954 24207091
SGTC_445 e6 berbamine 66 µM 0.170841546893454 0.437161251807647 no 1444 0.432174179793322 2007 6610268 A calcium/calmodulin antagonist.
SGTC_1141 3253-0389 52.6 µM 0.170154126608696 0.437430298831179 no 1445 0.432444463605973 2097 5402031
SGTC_2482 5981709 142.65 µM 0.169231739429542 0.43779135416553 no 1446 0.432807182688026 2034 877755
SGTC_52 0329-0193 875 nM 0.169201400721718 0.437803230702484 no 1447 0.432819114030107 2078 3739292
SGTC_1363 1636-0063 10.4 µM 0.168231770902624 0.438182836124263 no 1448 0.433200473779758 1998 6072185
SGTC_2377 9073351 62.6 µM 0.16805653607673 0.438251445797369 no 1449 0.433269401069287 1918 7337946 YHR072W ERG7
SGTC_1891 st059073 26.2 µM 0.167979855473977 0.438281469129666 no 1450 0.433299563441318 2145 688754
SGTC_1392 3455-1037 33.9 µM 0.167809360131448 0.438348225724334 no 1451 0.433366629302935 2075 981132
SGTC_905 2-aminofluorene 215 µM 0.167200268636564 0.438586726753493 no 1452 0.433606236526609 2108 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2717 st081029 62.2815 µM 0.165958145423294 0.439073172077013 no 1453 0.434094944222236 2124 5292846
SGTC_2587 piperic acid 92.2 µM 0.16435188944471 0.439702356900859 no 1454 0.434727067568375 1983 5370536
SGTC_1984 st072354 53.1 µM 0.163346767554645 0.440096149716301 no 1455 0.435122706585021 2030 5762938
SGTC_2904 7225135 42.03 µM 0.162705758417295 0.440347319180483 no 1456 0.435375056425482 2132 4446116
SGTC_1171 0368-0077 21.4 µM 0.162108940003271 0.440581194778715 no 1457 0.435610033107042 1998 3239779
SGTC_975 1335-0046 28.5 µM 0.161953519349784 0.440642102970817 no 1458 0.435671228367349 1947 16486740
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.16188349821785 0.440669544187867 no 1459 0.435698798960691 2087 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2937 9044753 11.33 µM 0.161474255362152 0.44082993178035 no 1460 0.435859943253049 2075 6465530 YGL099W LSG1
SGTC_1579 chlormadinone acetate 49.4 µM 0.160786476071232 0.441099503271919 no 1461 0.436130788588104 2125 45114258 A steroidal progestin.
SGTC_598 3937-0236 20.2 µM 0.160785006896445 0.44110007913654 no 1462 0.436131367176648 2071 1379313
SGTC_2403 6032726 181.2 µM 0.160197709937744 0.441330288761474 no 1463 0.436362666651497 2012 2881040
SGTC_150 3970-0969 77.2 µM 0.159990499966686 0.441411516000588 no 1464 0.436444278873967 2017 6615640
SGTC_1090 efavirenz 20.7 µM 0.158409917761188 0.442031192170013 no 1465 0.437066899604851 2053 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_3153 9100258 49.47 µM 0.158017675962109 0.442184994813288 no 1466 0.437221435150963 1977 25236848
SGTC_2231 micatex 6.853 µM 0.156026526273685 0.442965882067497 no 1467 0.438006056167187 2060 20737 An antifungal of unknown mechanism.
SGTC_2189 6047310 154.431 µM 0.152851043803347 0.444211697146777 no 1468 0.43925787175464 2070 711535
SGTC_1766 st045414 44.774 µM 0.151578313289583 0.444711174197668 no 1469 0.439759769612709 2107 253960
SGTC_3008 9078912 71.4286 µM 0.151292245006359 0.44482345245168 no 1470 0.439872593228436 2029 16648731
SGTC_491 tetrandrine 80.3 µM 0.151238562813506 0.44484452254033 no 1471 0.439893765707856 2127 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2391 6285546 200 µM 0.150432817403178 0.445160793722177 no 1472 0.44021157565772 1966 846083
SGTC_3055 9094636 49.47 µM 0.150117560871643 0.445284547725708 no 1473 0.440335932704769 2095 25236176
SGTC_66 0109-0187 42.4 µM 0.149224750028238 0.445635049663642 no 1474 0.440688145471484 2135 759417
SGTC_1443 4112-3303 14 µM 0.149064066169495 0.445698135859256 no 1475 0.440751540044762 2073 704433
SGTC_2499 avocadenofuran 51.48 µM 0.148121957784818 0.446068045263549 no 1476 0.44112326039133 2028 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2778 tioconazole 65.09 nM 0.147908762544812 0.446151760760579 no 1477 0.441207386381418 2104 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_934 2950-0684 338 µM 0.147658628790478 0.446249983985177 no 1478 0.441306091543521 2159 1121253
SGTC_2015 5119600 184 µM 0.146474943234041 0.446714841585388 no 1479 0.441773234483772 2128 2828786
SGTC_2475 5812728 15.03 µM 0.146301554458559 0.446782941078599 no 1480 0.441841669391147 2158 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2956 9076196 2.52 µM 0.14586316711613 0.446955127361587 no 1481 0.4420147044617 2172 16423868
SGTC_2262 9014885 67.46 µM 0.145580556111877 0.44706613436039 no 1482 0.442126259205018 2125 6457424
SGTC_3171 9103192 49.47 µM 0.144654903641112 0.447429751114724 no 1483 0.442491673117081 2175 13018434
SGTC_3291 9121177 71.43 µM 0.144199049467799 0.447608836969916 no 1484 0.442671645758198 2030 17015612
SGTC_1798 st045719 60.953 µM 0.14406273569913 0.44766239096958 no 1485 0.442725465156204 2144 3980186
SGTC_515 4092-1064 102 µM 0.1438032501698 0.447764338464737 no 1486 0.442827918145076 2165 717353
SGTC_2782 7736369 71.43 µM 0.143260088527516 0.447977748691457 no 1487 0.443042387689468 2025 2950836 YOL077C BRX1
SGTC_1144 3486-0183 12.5 µM 0.142809408729244 0.448154833891602 no 1488 0.443220353079709 2055 6744069
SGTC_1389 3405-0187 19 µM 0.14102915815047 0.448854446801794 no 1489 0.443923453835303 2005 799890
SGTC_2012 4023501 200 µM 0.140980046552464 0.448873749219017 no 1490 0.443942852719263 2031 3477460
SGTC_3159 9100096 49.47 µM 0.138792582594804 0.449733614068855 no 1491 0.44480702774331 2138 25236875
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.138613537210896 0.449804005086878 no 1492 0.444877772718444 2066 6708514
SGTC_247 mechlorethamine 29.705 µM 0.137067452210293 0.450411908052116 no 1493 0.445488739491669 2066 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2435 5706476 10.6 µM 0.137036227432067 0.450424186481801 no 1494 0.445501079933429 2181 5725375
SGTC_284 0988-0104 32.6 µM 0.136690730491485 0.450560048414016 no 1495 0.445637628376247 2147 4666532
SGTC_1656 st012921 11 µM 0.136248567981237 0.450733931204928 no 1496 0.445812390710511 2147 6732821
SGTC_1419 3993-2473 62.6 µM 0.136162266697636 0.45076787075391 no 1497 0.445846502053923 2077 704026
SGTC_2589 lobaric acid 100 µM 0.134832187136881 0.451290994103606 no 1498 0.446372278273805 2028 73157 A novel microtubule depolymerizer.
SGTC_2941 9056145 11.23 µM 0.133688351812454 0.451740934865977 no 1499 0.446824508191369 2206 2119517
SGTC_822 1487-0950 154 µM 0.133568932771078 0.451787913301657 no 1500 0.446871726033053 2185 1958375
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.131325968123823 0.452670401233393 no 1501 0.447758725046716 2083 5379071
SGTC_1404 3909-7820 48.3 µM 0.130729037669251 0.452905301366021 no 1502 0.447994830363738 2183 23741373
SGTC_668 1682-0499 62.6 µM 0.13005324715364 0.453171253876635 no 1503 0.448262149620671 2049 682214
SGTC_903 1134-0042 114 µM 0.129672443082627 0.45332112584853 no 1504 0.448412792843012 2034 701009
SGTC_1269 0831-0796 3.05 µM 0.128737510630126 0.453689112703769 no 1505 0.448782676587184 2162 927758
SGTC_3160 9100216 49.47 µM 0.127466087614858 0.454189605070502 no 1506 0.449285756183985 2205 17191039
SGTC_2887 9044784 58.44 µM 0.127104832445721 0.454331825535687 no 1507 0.449428713374103 2206 6465546
SGTC_1522 st012842 45.6 µM 0.126671636929864 0.454502375500083 no 1508 0.449600147709777 2030 3491067 YOR116C RPO31
SGTC_2048 5246248 200 µM 0.1263598842704 0.454625118354814 no 1509 0.449723527640125 2202 677046
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.126087885282875 0.454732212984773 no 1510 0.449831178538937 2104 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_326 k292-0812 17.5 µM 0.126072535133349 0.454738256923752 no 1511 0.449837253882689 2180 3579357
SGTC_1015 4130-4525 82 µM 0.125579022974768 0.454932577048298 no 1512 0.450032584361946 1987 1363237
SGTC_1958 st076513 41.9 µM 0.123751292070211 0.45565233859706 no 1513 0.450756099278174 2090 732122 YGL099W LSG1
SGTC_2990 9074105 71.4286 µM 0.123720735810249 0.455664372914736 no 1514 0.450768196498965 2204 6502001
SGTC_2219 9098279 200 µM 0.123688716649513 0.455676983426826 no 1515 0.450780872931121 2184 902349
SGTC_1754 st042065 16.137 µM 0.123662268874532 0.455687399723092 no 1516 0.450791343681441 2106 1126236 YIL048W NEO1
SGTC_545 4218-0007 221 µM 0.123529770297517 0.455739583944925 no 1517 0.450843800765242 2110 2840508
SGTC_3225 9130819 49.47 µM 0.1210826773683 0.456703501510352 no 1518 0.451812774837522 2171 4547121
SGTC_3105 9121040 49.47 µM 0.120366539946783 0.456985638733572 no 1519 0.452096397955706 2207 41448907
SGTC_2355 9061122 103.12 µM 0.119292479767281 0.457408827670592 no 1520 0.452521820616301 2182 5302957
SGTC_755 1995-0008 37.3 µM 0.118752392651873 0.457621644912726 no 1521 0.452735763426239 2198 689533
SGTC_1094 duloxetine 25.4 µM 0.11762594382801 0.458065552582758 no 1522 0.453182023721943 2122 60834 A selective serotonin reuptake inhibitor.
SGTC_741 4582-0002 126 µM 0.117455537578411 0.458132710349926 no 1523 0.453249537982462 2094 2912688
SGTC_839 0122-0028 230 µM 0.117382473766201 0.458161505449316 no 1524 0.453278485980647 2122 759448
SGTC_3302 9125395 16.351 µM 0.117197768986327 0.458234300227626 no 1525 0.453351667413928 2102 17599668
SGTC_3 0833-0587 95.581 µM 0.117134974564057 0.458259048720922 no 1526 0.453376547400782 2121 5382644
SGTC_1988 st071872 53.4 µM 0.116875739402893 0.458361220011191 no 1527 0.453479261762146 2209 16414116
SGTC_230 MPP+ 141.667 µM 0.115159775826771 0.459037594753873 no 1528 0.454159240370589 2067 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3204 9114183 49.47 µM 0.113600887123777 0.459652158762269 no 1529 0.45477709204108 2107 17027248
SGTC_505 gw-5074 63.9 µM 0.113107098047674 0.459846846457401 no 1530 0.454972823839649 2172 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2287 7945887 168.79 µM 0.113051486158078 0.459868773327446 no 1531 0.454994868381223 2190 1245853
SGTC_698 k064-0052 127 µM 0.112962748777805 0.459903761296289 no 1532 0.455030044147459 2211 5088751
SGTC_830 4076-0286 57.8 µM 0.112511117440342 0.460081838331915 no 1533 0.455209077635489 2127 6866659
SGTC_1309 pyrazolanthrone 13.4 µM 0.112016608104315 0.460276831230961 no 1534 0.455405119043035 2210 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2431 5490079 200 µM 0.110199781008302 0.460993316732426 no 1535 0.456125467973549 2124 5722345
SGTC_3068 9116768 49.47 µM 0.110010477691802 0.461067977876686 no 1536 0.456200532678437 2118 41904888
SGTC_2191 5911152 200 µM 0.109570041580587 0.461241690990221 no 1537 0.456375185461487 2207 2875902
SGTC_496 calpeptin 138 µM 0.109276633252104 0.461357418746423 no 1538 0.456491539777167 2094 73364 A calpain inhibitor.
SGTC_2890 9046729 58.44 µM 0.109080022476607 0.461434968901308 no 1539 0.456569510041462 2085 903329
SGTC_2814 7977482 42.97 µM 0.106426895875965 0.462481596887503 no 1540 0.457621827217222 2177 6456762
SGTC_1288 0973-0013 65.5 µM 0.106112240602847 0.462605742155747 no 1541 0.457746649691324 2150 4315430
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.106021764746394 0.462641439513328 no 1542 0.457782541869639 2246 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2820 7989630 71.43 µM 0.105827146879686 0.462718227245166 no 1543 0.45785974881726 2223 2984098
SGTC_869 0564-0080 44.1 µM 0.105019537796734 0.463036889419398 no 1544 0.458180152763777 2049 6843321
SGTC_596 1155-0152 116 µM 0.104863191592403 0.463098582435105 no 1545 0.45824218337097 2190 280313
SGTC_2271 7849410 118.62 µM 0.103676675333953 0.46356680149045 no 1546 0.458712968636348 2254 972430
SGTC_2195 6536160 144.242 µM 0.101544303693222 0.464408397243753 no 1547 0.459559195013153 2167 3834386
SGTC_1575 cyproterone acetate 48 µM 0.100255360050404 0.46491718974213 no 1548 0.460070798195769 2113 9880 An androgen receptor antagonist and liver toxin.
SGTC_2630 antimycin a 100 µM 0.0994861186995237 0.465220864406937 no 1549 0.46037615444665 2212 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1982 st072467 71.9 µM 0.097725292369331 0.465916064660052 no 1550 0.461075215638172 2087 3163533
SGTC_3057 9095946 49.47 µM 0.097048775679308 0.466183191221545 no 1551 0.461343829918687 2242 24540043
SGTC_2280 7785178 200 µM 0.0966328588456667 0.466347425979777 no 1552 0.461508980506129 2159 2954328
SGTC_1268 0828-0275 2.46 µM 0.0952363557673132 0.466898910549185 no 1553 0.462063546742211 2197 745337
SGTC_2116 5511452 16.8835 µM 0.094958728066169 0.467008554429193 no 1554 0.462173804480895 2162 870744
SGTC_534 k292-0788 63.4 µM 0.0937591336852767 0.467482340518536 no 1555 0.462650247610712 2275 4146317
SGTC_2955 9076254 12.21 µM 0.0937087703569549 0.467502232791474 no 1556 0.462670251600386 2231 16459619
SGTC_1885 st057546 99.9 µM 0.0932614502454818 0.467678916762338 no 1557 0.462847928405264 2224 702008
SGTC_100 0086-0128 49.5915 µM 0.0907750332100068 0.468661125058843 no 1558 0.463835674370607 2131 93297
SGTC_2445 5742597 35.57 µM 0.0898841165422866 0.469013110240639 no 1559 0.46418965160957 2153 1774255
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.0874355527698397 0.469980617767379 no 1560 0.465162655277729 2250 3256 An antibiotic and ribosome inhibitor.
SGTC_2866 9034245 58.44 µM 0.0861177959911743 0.470501380245646 no 1561 0.465686388511705 2267 6462273
SGTC_2322 7413319 38.22 µM 0.0861175660274756 0.470501471129111 no 1562 0.465686479914385 2176 1840400
SGTC_101 0490-5701 117.494 µM 0.0847730373488756 0.471032865561335 no 1563 0.466220914718746 2254 4661669
SGTC_1178 0988-0033 191 µM 0.0839075635817291 0.47137495176388 no 1564 0.466564962950917 2199 5392207
SGTC_2720 fluspirilene 36.88 µM 0.0830899961391216 0.471698121969731 no 1565 0.466889990132343 2230 3396 An atypical antipsychotic.
SGTC_1049 3226-0134 66 µM 0.0819773411104652 0.472137965069281 no 1566 0.467332365985952 2242 5702385
SGTC_603 3794-0023 45.9 µM 0.0796956097913105 0.473040060837678 no 1567 0.468239675613836 2261 3802260
SGTC_3299 9121982 43.1275 µM 0.0792719875398825 0.473207557721116 no 1568 0.46840814343579 2154 17594604 YPL160W CDC60
SGTC_1841 st054148 70 µM 0.0788758159901605 0.473364205101796 no 1569 0.468565699670945 2138 675442
SGTC_339 3091-4833 71.4 µM 0.0781051487419703 0.473668940946713 no 1570 0.468872205802419 2204 3240077
SGTC_991 3996-0057 64.7 µM 0.0776198048942098 0.473860862649478 no 1571 0.469065243940996 2196 715343
SGTC_3154 9100113 49.47 µM 0.0775854442221392 0.473874450275218 no 1572 0.469078910652238 2196 25237525
SGTC_701 4424-0219 185 µM 0.0771811552263472 0.474034325083269 no 1573 0.469239716436976 2276 2911779
SGTC_3263 9137018 49.47 µM 0.0768012593903522 0.474184557504779 no 1574 0.469390824425524 2158 43844957
SGTC_1042 0350-0096 82 µM 0.0762160925016697 0.47441597295125 no 1575 0.46962358998167 2148 3122515
SGTC_2748 diazoxide 86.69 µM 0.0761252183375737 0.47445191165518 no 1576 0.469659738509343 2243 3019 A potassium channel activatior.
SGTC_385 1494-0393 12.4 µM 0.0756095499105876 0.474655850938754 no 1577 0.469864869243068 2200 3090647
SGTC_1360 1598-0022 39.8 µM 0.0754115077807711 0.47473417545821 no 1578 0.46994365169888 2238 761525
SGTC_3310 9130229 44.1445 µM 0.0752168827870372 0.474811149471464 no 1579 0.470021075941925 2254 7761258
SGTC_2610 ononetin 44.17 µM 0.075106503482488 0.474854804807015 no 1580 0.470064986705927 2198 259632
SGTC_1768 st044301 37.178 µM 0.0739139415859435 0.47532648564351 no 1581 0.470539431206652 2266 3931349
SGTC_1925 st057770 10.1 µM 0.0724572609255701 0.47590267731003 no 1582 0.471119008433649 2138 5989122
SGTC_951 1171-0579 82.7 µM 0.070616582558754 0.476630831619807 no 1583 0.471851456193718 2276 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3035 9091303 49.47 µM 0.0703048936665614 0.476754140481382 no 1584 0.471975493782485 2281 25237002
SGTC_2176 5809774 33.9695 µM 0.0701964293268505 0.476797051144856 no 1585 0.472018658150537 2276 2870539
SGTC_1022 4477-0945 21.3 µM 0.0683597218512182 0.477523729833263 no 1586 0.472749642049378 2270 4648966
SGTC_1414 3917-0015 5.4 µM 0.0678418389613726 0.477728639687417 no 1587 0.47295576889461 2279 6618702
SGTC_1318 1280-3875 124 µM 0.0675216688821275 0.477855323794236 no 1588 0.473083206057735 2234 373245
SGTC_1816 st051957 91.6 µM 0.0652448622712514 0.478756268799802 no 1589 0.47398952113564 2285 674121
SGTC_3157 9099274 49.47 µM 0.0645732701764321 0.479022042457758 no 1590 0.474256883794351 2284 17217662
SGTC_2857 9024691 58.44 µM 0.0639718111843759 0.47926006979222 no 1591 0.474496336117557 2235 16478292
SGTC_728 3030-5151 22.5 µM 0.0625827661445933 0.479809812349677 no 1592 0.475049376568691 2275 3125388
SGTC_537 1334-0398 209 µM 0.062261625672958 0.479936915665151 no 1593 0.475177243718266 2311 5846986
SGTC_2264 7948757 110.76 µM 0.0608248839956602 0.480505584549619 no 1594 0.475749336222874 2302 2971411
SGTC_2147 5545932 89.7195 µM 0.0607352770431621 0.480541052714995 no 1595 0.475785018255317 2237 797404
SGTC_1017 4239-0030 168 µM 0.0596510688355031 0.480970215425603 no 1596 0.476216771851367 2137 1149593
SGTC_3023 9089636 49.47 µM 0.0595711572219117 0.481001847760869 no 1597 0.476248595380242 2322 17249241
SGTC_2611 pyromycin 23.93 µM 0.0593246555533888 0.481099424110853 no 1598 0.47634676170189 2239 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_690 glyoxal 20.3 µM 0.0579735564209937 0.481634269340914 no 1599 0.476884846004667 2249 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_198 3454-2873 16.191 µM 0.0575495772557478 0.481802112319449 no 1600 0.477053707289062 2254 710957
SGTC_2248 tofa 1.1 µM 0.0567893018865229 0.482103094795927 no 1601 0.477356518021816 2235 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3071 9117417 49.47 µM 0.056141616702728 0.482359512432624 no 1602 0.477614495432642 2293 45595590 YGL055W OLE1
SGTC_1196 1588-0294 184 µM 0.0560199835326051 0.48240766764757 no 1603 0.477662943800521 2220 6144269
SGTC_1188 1403-0014 4.57 µM 0.0552231218567604 0.482723155713393 no 1604 0.477980354230921 2260 9614867
SGTC_549 1661-1316 519 µM 0.0551122825383623 0.482767039325528 no 1605 0.478024505483567 2300 2857282
SGTC_633 0437-0093 97.7 µM 0.0545369803662902 0.48299481687047 no 1606 0.478253673172657 2298 2831118
SGTC_2981 9013952 38.96 µM 0.0539017151707636 0.48324634182834 no 1607 0.478506735072865 2141 2996344
SGTC_1076 itraconazole 331 nM 0.0530862594553127 0.483569220628287 no 1608 0.478831589690814 2316 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2031 5180455 200 µM 0.0526367776337307 0.4837471970847 no 1609 0.479010656630382 2314 29949
SGTC_407 eburnamonine 100 µM 0.051808012795255 0.484075362599926 no 1610 0.479340835420162 2300 3195
SGTC_2769 toremifene 3.73 µM 0.0514409158382952 0.484220725221934 no 1611 0.479487090894913 2280 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_118 0083-0097 135.343 µM 0.0505833989583314 0.484560291886893 no 1612 0.479828745800647 2322 5207356
SGTC_2840 9008771 71.43 µM 0.0497948499351454 0.484872557974983 no 1613 0.480142935375101 2310 2992978
SGTC_78 0336-0123 156.75 µM 0.0495359777967185 0.484975073595462 no 1614 0.480246083122701 2164 6765896
SGTC_1258 0671-0043 57.1 µM 0.0493275003865655 0.485057633187061 no 1615 0.480329152024648 2267 4298767
SGTC_2514 salinomycin 42.74 µM 0.0491819898919691 0.485115257493559 no 1616 0.480387131939956 2318 23682228 A polyether potassium ionophore.
SGTC_613 3914-0030 117 µM 0.0489143770488165 0.485221236945406 no 1617 0.480493765674692 2299 1145395
SGTC_36 0335-0881 14.2 µM 0.047063126756481 0.485954393214566 no 1618 0.481231457670526 2296 23828853
SGTC_640 3381-0960 37.1 µM 0.0467793425190944 0.486066785405706 no 1619 0.481344546643939 2303 1745025
SGTC_1905 st060207 84.5 µM 0.0466532071959544 0.486116741409098 no 1620 0.481394812477084 2220 1948547
SGTC_1503 4585-0012 61.3 µM 0.0466434770963391 0.486120595032495 no 1621 0.481398690004036 2289 2922052
SGTC_2658 polymyxin b sulfate 77.05 µM 0.046449753551498 0.486197319859047 no 1622 0.481475890840168 2306 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2459 5811157 9.22 µM 0.04602075910528 0.486367226289363 no 1623 0.481646852032042 2327 2870684 YBR192W RIM2
SGTC_120 rhodamine 6G 52.259 µM 0.045939454101424 0.486399428018703 no 1624 0.48167925376618 2331 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_820 1582-0060 59.9 µM 0.0448092329401447 0.486847073469393 no 1625 0.482129682832254 2276 3848840
SGTC_1237 0330-0133 46.1 µM 0.0446157426952597 0.486923710614702 no 1626 0.4822067971494 2311 X1237 YHR072W ERG7
SGTC_1255 0566-0045 221 µM 0.0434454596856525 0.487387243652656 no 1627 0.482673220150473 2269 2788469
SGTC_3181 9108277 49.47 µM 0.0433890571629146 0.487409584353207 no 1628 0.482695700303324 2321 17097298
SGTC_1849 st056239 19.2 µM 0.0432645870295386 0.487458886365278 no 1629 0.482745310116178 2275 5393181
SGTC_1972 st070201 17.4 µM 0.04287210935255 0.487614346108187 no 1630 0.482901740906964 2332 2829099
SGTC_279 1273-0055 2.93 µM 0.042558833128053 0.48773843564173 no 1631 0.483026606070666 2336 2847562
SGTC_2874 9043904 71.43 µM 0.0421418860076758 0.487903591328078 no 1632 0.483192794803482 2210 4463428
SGTC_1829 berberine 14.4 µM 0.0417019855356003 0.488077841246731 no 1633 0.483368135555645 2326 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1465 k213-0056 144 µM 0.040972967967249 0.488366618952937 no 1634 0.483658723098189 2234 24048857 YMR208W ERG12
SGTC_3024 9090631 49.47 µM 0.0400317693100514 0.488739454617223 no 1635 0.484033899169461 2348 25236383
SGTC_1234 0326-0494 15.5 µM 0.0391191511297188 0.489100978138442 no 1636 0.484397696130762 2314 1547813
SGTC_2592 piperlongumine 83.33 µM 0.0386990327755246 0.489267406370346 no 1637 0.484565172283265 2296 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_367 0335-0881 7.1 µM 0.0380267775287862 0.489533721515084 no 1638 0.484833166041912 2309 23828853
SGTC_2661 dactinomycin 12.96 µM 0.0377135012553939 0.489657828084542 no 1639 0.484958055605163 2344 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2056 5235370 200 µM 0.0366122954051342 0.490094086289447 no 1640 0.485397069894246 2316 5511916
SGTC_2803 7707263 71.43 µM 0.03629747543569 0.490218808854809 no 1641 0.485522581462695 2313 2199229
SGTC_2735 sertaconazole 140 nM 0.0356562963364481 0.490472828411532 no 1642 0.485778209422497 2362 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_630 4356-0227 183 µM 0.034244535776829 0.491032147066829 no 1643 0.486341076467876 2346 779312
SGTC_1260 0700-1617 7.75 µM 0.0340976591634083 0.491090338440504 no 1644 0.4863996375591 2300 2853078
SGTC_3147 9097027 49.47 µM 0.0333217652359036 0.49139774470686 no 1645 0.486708998623787 2304 25236841
SGTC_3001 9076041 71.4286 µM 0.0325031210978596 0.491722093982087 no 1646 0.487035413535026 2343 16004211
SGTC_1583 clindamycin 39.6 µM 0.0319391310024328 0.49194555175525 no 1647 0.487260296259805 2273 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2603 homopterocarpin 100 µM 0.0289652798857556 0.493123857542987 no 1648 0.488446140802953 2330 101795 A weak amylase inhibitor.
SGTC_1667 st014849 34.6 µM 0.028927507677645 0.493138824137462 no 1649 0.488461203422033 2351 5348460
SGTC_2245 6637752 200 µM 0.0280380883569659 0.493491244148443 no 1650 0.488815886481364 2345 681890
SGTC_518 1021-0119 62.6 µM 0.0276438101167363 0.49364747304804 no 1651 0.488973119791585 2255 1097762
SGTC_2011 4012611 177 µM 0.0246925502648614 0.49481691022129 no 1652 0.490150098648901 2343 2049887
SGTC_533 1222-0222 6.71 µM 0.023687999113136 0.495214974436085 no 1653 0.490550739320831 2351 3982874
SGTC_3093 9117344 49.47 µM 0.0234412503502005 0.495312752035483 no 1654 0.49064915050751 2336 24824913
SGTC_2721 ifenprodil 61.44 µM 0.0231908801276104 0.495411964975991 no 1655 0.490749006628269 2348 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2618 avocadyne 43.43 µM 0.0220786947362601 0.495852688395238 no 1656 0.491192590735589 2349 3015189
SGTC_706 4262-0057 46.9 µM 0.0215639665544385 0.49605666042003 no 1657 0.491397888683737 2373 883298
SGTC_2818 7996756 12.99 µM 0.0207373071912664 0.496384243965862 no 1658 0.491727604288516 2367 2241621
SGTC_1040 k898-0338 155 µM 0.0206819457127649 0.496406182365492 no 1659 0.491749685587276 2364 20969351
SGTC_889 0919-1524 82.7 µM 0.0204835953345454 0.496484783856919 no 1660 0.491828799179323 2286 3905452
SGTC_2524 avocatin b 10.57 µM 0.0203490877990975 0.4965380860408 no 1661 0.491882448739747 2362 6710748
SGTC_2770 toltrazuril 17.5 µM 0.0200207203352623 0.496668210628541 no 1662 0.492013421720089 2362 68591 Kills coccidiodes.
SGTC_1642 st009582 77.7 µM 0.0200034387533857 0.496675058937917 no 1663 0.492020314693373 2365 6739311
SGTC_3210 9128157 49.47 µM 0.0198438851248287 0.496738286564501 no 1664 0.492083954749441 2273 17590849
SGTC_2854 9024559 71.43 µM 0.01964301788703 0.49681788599058 no 1665 0.492164073566378 2355 3163529
SGTC_2236 dapsone 200 µM 0.0179494950869365 0.497488997882394 no 1666 0.492839571996363 2378 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1558 st069300 45.6 µM 0.0173036919127402 0.497744919759697 no 1667 0.493097170162321 2369 24208000
SGTC_1872 amphotericin b 148 nM 0.0153885050088997 0.498503883960445 no 1668 0.493861117008213 2375 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_987 1497-1013 404 µM 0.0152519892868439 0.498557983643256 no 1669 0.493915572510639 2367 1676435
SGTC_2193 5925765 200 µM 0.0151027810234579 0.49861711327123 no 1670 0.49397509113989 2363 877370
SGTC_702 1488-0190 94 µM 0.0150434674216569 0.498640618621394 no 1671 0.493998751155529 2380 949357
SGTC_1676 st018489 23.4 µM 0.0139459359627494 0.499075559442508 no 1672 0.494436556843476 2345 3696235
SGTC_2912 7964298 10.93 µM 0.0134816853927653 0.499259537695038 no 1673 0.494621748607683 2372 2975850
SGTC_126 0417-1624 672.48 µM 0.0134473361817536 0.499273149979769 no 1674 0.494635450718149 2378 41912 YDL195W SEC31
SGTC_1928 4'-methoxychalcone 40.3 µM 0.0128843833165378 0.499496243268083 no 1675 0.494860016951008 2383 641818
SGTC_2677 mitomycin C 100 µM 0.0128712810335486 0.499501435590185 no 1676 0.494865243572256 2380 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2518 prenyletin 46.28 µM 0.0125771638590741 0.499617991718348 no 1677 0.494982569849834 2384 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2288 7946289 167.31 µM 0.0118305299425405 0.499913876496095 no 1678 0.495280411500022 2378 1246052
SGTC_1949 st076024 69.1 µM 0.0113958829324887 0.499913876496095 no 1679 0.495453798875543 2385 2921930
SGTC_2859 9028643 45.46 µM 0.0112874768366148 0.49987091606 no 1680 0.495497043869148 2371 17151580
SGTC_2054 5233173 129 µM 0.0111750527867471 0.499826363343671 no 1681 0.495541891747276 2374 6889
SGTC_1608 st001473 40.5 µM 0.010390173149816 0.499515322159826 no 1682 0.495854995209462 2384 7292267
SGTC_490 phenamil 164 µM 0.00950544589624298 0.499164712570029 no 1683 0.496207932842431 2381 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2127 5253358 187.912 µM 0.00861839027890947 0.498813180918198 no 1684 0.496561802291764 2392 20612
SGTC_1758 st042942 75.2445 µM 0.00817295496124614 0.498636659495185 no 1685 0.496739499008902 2393 669317
SGTC_1737 st035557 69.7 µM 0.00789581938404007 0.49852683365629 no 1686 0.496850056539321 2393 5716916
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.00759477769680976 0.498407534210723 no 1687 0.496970151193795 2393 2374 Ca(2+)-ATPase inhibitor.
SGTC_2113 5491891 107.031 µM 0.00735718795135719 0.498313380158318 no 1688 0.497064933139689 2388 789979
SGTC_1064 honokiol 6.76 µM 0.00683643806634253 0.498107013372315 no 1689 0.497272677052437 2374 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_400 oxethazaine 37.5 µM 0.00646067719198601 0.497958104262596 no 1690 0.497422580638502 2354 4621 A local anesthetic.
SGTC_2919 7978188 46.38 µM 0.00620577574610261 0.497857090321058 no 1691 0.497524269562945 2393 2980291
SGTC_1955 wogonin 32.4 µM 0.00605665278880669 0.4977979950048 no 1692 0.497583759897349 2388 5281703 A flavanone.
SGTC_1124 fisetin 1.16336 µM 0.00548011259912398 0.497569520758148 no 1693 0.497813762325569 2382 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2975 9084847 53.72 µM 0.00435536215052226 0.497123801355252 no 1694 0.49826246738496 2367 27211724
SGTC_3186 9110464 49.47 µM 0.00363733649448093 0.496839261887245 no 1695 0.498548915883998 2397 17018021
SGTC_936 3005-4620 401 µM 0.00344217037339537 0.496761921657681 no 1696 0.498626775413492 2400 777207
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.00246374198402091 0.496374192955772 no 1697 0.499017110148935 2396 16725076
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.00208904284508645 0.496225709178693 no 1698 0.499166593089703 2400 6728940
SGTC_245 methotrexate 289.6 µM 0.00169759361992926 0.496070588325534 no 1699 0.499322758455352 2381 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_16 erodoxin 22.806 µM 0.00165688396643599 0.496054456212906 no 1700 0.499338999234506 2402 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_340 k038-0059 454 µM 0.00086257931849862 0.495739696516957 no 1701 0.499655880682324 2402 23733424
SGTC_1376 2910-0861 41.3 µM 0.000391542333070355 0.495553039579217 no 1702 0.499843797212762 2404 1112859
SGTC_3279 9140807 49.47 µM -0.000131056530765186 0.495345951454177 no 1703 0.499947716008905 2406 45595718
SGTC_2376 9072922 81.32 µM -0.000421365330884852 0.495230912505669 no 1704 0.499831899558989 2412 17087968
SGTC_1241 0364-0022 50.8 µM -0.000803081971336831 0.495079652518838 no 1705 0.499679616681444 2411 4563895
SGTC_1202 1988-0068 29.6 µM -0.000988337227931046 0.495006243062998 no 1706 0.499605710556675 2401 2850480
SGTC_1329 1447-1697 50.6 µM -0.00176735536814412 0.494697550340423 no 1707 0.499294927586207 2423 2840515
SGTC_2319 6033012 152.6 µM -0.00223868393303682 0.494510783821588 no 1708 0.499106895072653 2412 847246
SGTC_2363 9053361 176 µM -0.00263884471335351 0.49435221886899 no 1709 0.498947254494229 2408 6469797 YMR079W SEC14
SGTC_2258 7960471 200 µM -0.00271345042064675 0.494322656223598 no 1710 0.498917491229816 2413 2974708
SGTC_1818 st052136 56.3 µM -0.00313371231963715 0.494156127279171 no 1711 0.498749831707223 2422 674169
SGTC_1086 cerivastatin 2.18 µM -0.00328264622582077 0.494097112402584 no 1712 0.498690415980882 2412 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3097 9117246 49.47 µM -0.00414917508077867 0.493753754016451 no 1713 0.498344723380936 2412 16423892
SGTC_2359 9039622 200 µM -0.00420980518566968 0.493729729764631 no 1714 0.498320535679891 2415 6463596
SGTC_1940 st075990 51.1 µM -0.00465056593355698 0.493555082113278 no 1715 0.498144699308979 2458 1084979
SGTC_3070 9117005 49.47 µM -0.00481728785615951 0.493489020307154 no 1716 0.49807818763033 2416 8779016
SGTC_1690 st023502 41.2 µM -0.00522817362185565 0.493326211915538 no 1717 0.497914269994788 2411 24207482
SGTC_2674 ligustilide 100 µM -0.0057324062037054 0.493126417527103 no 1718 0.497713113321613 2424 5319022 A signalling regulator.
SGTC_265 mycophenolic acid 32.932 µM -0.00606079780985807 0.492996298338957 no 1719 0.497582106303549 2422 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1243 0416-0003 5.65 µM -0.00724106469898882 0.492528645348643 no 1720 0.497111258380713 2424 2141977
SGTC_733 4069-0007 56.1 µM -0.00910096348414845 0.491791725298274 no 1721 0.4963692909943 2422 5717425 YNL287W SEC21
SGTC_2330 7979373 200 µM -0.0092919548863471 0.491716053157357 no 1722 0.496293099670889 2418 1863007
SGTC_2739 tacrine 100.86 µM -0.00987474491558209 0.491485149490766 no 1723 0.496060610767125 2437 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_176 1486-1328 72.834 µM -0.0107040727546626 0.491156571527063 no 1724 0.495729774350892 2443 22310231
SGTC_1455 4262-0120 131 µM -0.0109269995829791 0.491068249395736 no 1725 0.495640844615291 2433 1529587
SGTC_1588 farnesol 29.9 µM -0.0115820542286172 0.490808723638473 no 1726 0.495379532175857 2430 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1023 4482-3888 16 µM -0.0121334056796 0.490590287006928 no 1727 0.495159590236581 2417 3303168
SGTC_419 nsc-638432 893 µM -0.0122450456977955 0.490546057357722 no 1728 0.495115055621698 2438 368090
SGTC_2991 9074669 71.4286 µM -0.0123488768946966 0.49050492151913 no 1729 0.495073636098999 2436 17333109
SGTC_251 melphalan 456.522 µM -0.0126568053645963 0.490382927028296 no 1730 0.494950800014809 2434 460612 A DNA alkylator.
SGTC_2800 7887935 81.82 µM -0.0126623818023623 0.490380717774494 no 1731 0.494948575516272 2439 2961002
SGTC_775 4577-0580 57.3 µM -0.0133465528581145 0.49010966751514 no 1732 0.494675653839138 2487 2006902
SGTC_2755 lomerizine 42.69 µM -0.014433145682924 0.489679197959817 no 1733 0.494242207854994 2440 3949 A calcium channel blocker.
SGTC_999 SEC7.066 22.7 µM -0.0154029052838449 0.489295023722808 no 1734 0.493855372810495 2450 740511 YDR170C SEC7
SGTC_1325 1431-0015 227 µM -0.0158745446536833 0.489108185422745 no 1735 0.49366723893384 2427 1103340
SGTC_565 1418-0001 44.5 µM -0.0169405554944385 0.488685897796262 no 1736 0.493242019398266 2449 2862145
SGTC_1658 st012944 20 µM -0.0175165873051871 0.488457714834126 no 1737 0.493012250060298 2456 24207260
SGTC_1721 st082152 9.2685 µM -0.0198203068150035 0.487545183015544 no 1738 0.492093359284491 2446 5296051
SGTC_796 1234-0020 70.7 µM -0.0201013378523404 0.487433867508981 no 1739 0.491981266455006 2441 46495034
SGTC_2303 7774051 200 µM -0.0212985747949376 0.486959656810797 no 1740 0.491503740365565 2475 2953184
SGTC_929 2805-0021 398 µM -0.0214899329915576 0.486883863894989 no 1741 0.491427416959497 2502 3098024
SGTC_1908 st060353 56.5 µM -0.0216946901393575 0.486802764464058 no 1742 0.491345749716161 2452 4227716
SGTC_2835 9006588 71.43 µM -0.0216958462211184 0.486802306569146 no 1743 0.491345288614797 2521 2345538
SGTC_2702 st077768 96.8 µM -0.0237326819891428 0.485995594712602 no 1744 0.49053291844236 2475 6484119
SGTC_2942 9052777 62.25 µM -0.0238056258437961 0.485966705516706 no 1745 0.490503826273951 2458 6469503
SGTC_2756 carbadox 75.1 µM -0.0240205485499341 0.48588158644925 no 1746 0.490418109031215 2467 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_655 k060-0012 42 µM -0.024179900985846 0.485818476125636 no 1747 0.490354555066525 2447 5994525
SGTC_2828 7998861 71.43 µM -0.0278666091657597 0.484358485735193 no 1748 0.488884270060441 2461 2988188
SGTC_1128 3448-9350 235 µM -0.0280008653631396 0.484305322154612 no 1749 0.488830730479314 2508 619386
SGTC_2679 rapamycin 1 nM -0.0287087155995723 0.484025027974808 no 1750 0.488548452595394 2466 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_504 lovastatin 124 µM -0.0295051330232819 0.483709672449156 no 1751 0.488230862582317 2459 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1997 st073024 93.8 µM -0.0298712084665131 0.483564721827332 no 1752 0.488084883957054 2451 686268
SGTC_2283 7944793 200 µM -0.0300655719246413 0.48348776287825 no 1753 0.488007378967565 2478 2970533
SGTC_916 4466-0038 42 nM -0.0302640984763474 0.483409156171562 no 1754 0.487928214357255 2458 5722064 YGL116W CDC20
SGTC_2847 9005661 71.43 µM -0.0310267929101017 0.483107172879516 no 1755 0.487624086151496 2463 2991449
SGTC_2940 9060638 45.86 µM -0.0315485616714484 0.482900587920203 no 1756 0.48741603239315 2488 4027022
SGTC_2188 6126565 140.678 µM -0.0324283707808871 0.482552253748377 no 1757 0.487065218885006 2462 874518
SGTC_2211 7117706 200 µM -0.0335354261783565 0.482113967142683 no 1758 0.486623807852743 2457 822771
SGTC_1741 st038134 10.228 µM -0.0345272886038106 0.481721304129104 no 1759 0.486228341079022 2512 1272587
SGTC_1026 k007-1105 30.6 µM -0.0346927746534975 0.481655792473929 no 1760 0.486162361226022 2462 7066794
SGTC_2582 agaric acid 100 µM -0.0357881939593969 0.481222156823675 no 1761 0.485725623446687 2457 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1814 st052110 31.539 µM -0.0360248928947812 0.481128459444165 no 1762 0.485631255087081 2483 674163
SGTC_1876 myriocin 605 nM -0.036726527325771 0.480850723285865 no 1763 0.485351528580119 2487 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2163 5671233 125 µM -0.0369240793528682 0.480772525628942 no 1764 0.485272770144442 2471 701023
SGTC_772 k072-0172 35.3 µM -0.0371915562764605 0.480666650554017 no 1765 0.485166135535737 2480 5861980
SGTC_2397 5161689 200 µM -0.0375533992495205 0.480523424848913 no 1766 0.4850218818506 2506 2259942
SGTC_3113 9123498 49.47 µM -0.0377982812925568 0.480426496374123 no 1767 0.484924257362224 2462 8897275
SGTC_151 3013-0144 2.285 µM -0.0394512688169717 0.479772246375295 no 1768 0.484265302546628 2578 906558 YHR107C CDC12
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.0395247403803267 0.479743167691826 no 1769 0.484236014476989 2475 140250 A respiratory chain inhibitor.
SGTC_572 0960-0087 17.7 µM -0.0409076480361444 0.479195858747401 no 1770 0.483684760150842 2470 6796365
SGTC_135 0933-0004 26.348 µM -0.0413206422053564 0.47903241692401 no 1771 0.483520138511149 2500 21230617 YGL099W LSG1
SGTC_747 3448-8087 38.7 µM -0.0416525800592229 0.478901055570264 no 1772 0.483387828378448 2510 5168703
SGTC_881 0833-0569 170 µM -0.0428034608382108 0.478445622922343 no 1773 0.482929102584917 2478 5418700
SGTC_2022 5136654 200 µM -0.0445229351326122 0.477765236049146 no 1774 0.482243785254752 2544 1713771
SGTC_3236 9132701 49.47 µM -0.0445825898791566 0.477741632133492 no 1775 0.482220010062113 2496 24282524
SGTC_399 oxolinic acid 75 µM -0.0449456010066544 0.477597999246933 no 1776 0.482075334600629 2495 4628 A DNA gyrase inhibitor.
SGTC_1420 4'-methoxyflavone 42 µM -0.0463078197744117 0.47705903522015 no 1777 0.481532453359334 2482 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_181 1447-1644 8.07 µM -0.0466220496539389 0.476934715587577 no 1778 0.481407229027178 2476 534600
SGTC_3261 9137475 49.47 µM -0.0468355983734106 0.476850230000039 no 1779 0.481322128377122 2477 17027690
SGTC_813 k007-0158 173 µM -0.046894606957144 0.476826884808696 no 1780 0.481298613195993 2538 6523916
SGTC_1055 3448-0672 86 µM -0.0479919669418742 0.476392757822155 no 1781 0.480861322341664 2570 748378
SGTC_1666 st014829 29 µM -0.049055021756491 0.475972229029838 no 1782 0.480437723830906 2483 3858230
SGTC_2172 5754775 163.918 µM -0.0519789507236467 0.474815705329794 no 1783 0.479272732812942 2512 2263357
SGTC_2492 derrusnin 100 µM -0.0524424400934934 0.474632397112012 no 1784 0.479088079158972 2471 1715307 Part of coumarin class of compounds.
SGTC_2234 tolnaftate 200 µM -0.054757207687259 0.473716996810114 no 1785 0.478165946270681 2491 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2636 apigenin dimethyl ether 100 µM -0.0548497061986421 0.473680420107744 no 1786 0.478129100077473 2577 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3311 9131146 2.8755 µM -0.0551562084670561 0.473559221450127 no 1787 0.478007008187636 2559 4900406 YPR165W RHO1
SGTC_1112 tnp00069 1.16933 µM -0.0567426045448152 0.472931960155726 no 1788 0.477375117574298 2622 145826
SGTC_2246 7293507 91.5585 µM -0.0567484942698045 0.472929631481497 no 1789 0.477372771693956 2559 887656
SGTC_606 k015-0008 38.6 µM -0.0572901108102309 0.47271549158012 no 1790 0.477157048923064 2537 1970475
SGTC_2737 bleomycin 30.5 nM -0.0589920605972745 0.472042640254081 no 1791 0.476479215912866 2510 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2243 6634756 200 µM -0.0590129518566989 0.472034381564661 no 1792 0.47647089600084 2629 885676
SGTC_3247 9135149 49.47 µM -0.0595911610753173 0.471805809877759 no 1793 0.476240629149623 2502 8934436 YOR116C RPO31
SGTC_800 3448-7362 155 µM -0.0616751180095273 0.470982079164772 no 1794 0.475410777594624 2506 15991913
SGTC_1229 0139-0193 12.2 µM -0.0618055917911931 0.470930510569254 no 1795 0.475358825199018 2516 3090752
SGTC_51 1013-0126 23.419 µM -0.0621890836234508 0.470778941676801 no 1796 0.475206127835176 2502 1627850
SGTC_1387 3342-1166 1.8 µM -0.0626947473048605 0.470579092827474 no 1797 0.475004790105164 2587 3418228
SGTC_2254 7938975 95.19 µM -0.0627522422085348 0.47055637010878 no 1798 0.47498189803292 2582 2969277
SGTC_352 k048-0007 5.11 µM -0.0631202858080434 0.470410916861763 no 1799 0.474835360384303 2506 6811911
SGTC_1194 1488-0194 225 µM -0.0641181588115581 0.470016570815988 no 1800 0.474438071477894 2516 1391452
SGTC_687 k029-0044 34.9 µM -0.0649467442664943 0.4696891472709 no 1801 0.474108201293856 2528 5829338
SGTC_2844 9010103 25.97 µM -0.0650795047708724 0.469636687574616 no 1802 0.474055349328508 2649 2480525
SGTC_234 nsc-17383 10.7 µM -0.0662783721254324 0.469162984690762 no 1803 0.473578100950233 2540 408974
SGTC_3110 9122132 49.47 µM -0.0676892436967548 0.468605569524293 no 1804 0.473016505979704 2670 918317
SGTC_2787 5284540 71.43 µM -0.0676900522386179 0.468605250098514 no 1805 0.473016184156294 2579 736958
SGTC_1742 st038235 28.8875 µM -0.0698983205545369 0.467732918892664 no 1806 0.472137294932539 2619 564103 YBR002C RER2
SGTC_2295 7971645 200 µM -0.0701108372560761 0.467648976624831 no 1807 0.472052720523676 2599 2978226 YKL099C UTP11
SGTC_2337 9009472 200 µM -0.0706726374574008 0.467427077319007 no 1808 0.471829149257312 2550 5742383
SGTC_1770 st043884 66.3 µM -0.070904497324544 0.467335500477405 no 1809 0.471736882019781 2535 670149
SGTC_958 1222-0007 33 µM -0.0715295402414045 0.467088638194269 no 1810 0.471488157526036 2616 7312461
SGTC_2416 tofa 880 nM -0.0722630242880669 0.466798962962696 no 1811 0.471196295039585 2583 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1647 st011722 22.4 µM -0.0750629565913098 0.46569334726189 no 1812 0.470082310499784 2597 2854783
SGTC_2845 9003024 42.97 µM -0.0750640320575179 0.465692922640397 no 1813 0.470081882657886 2672 2990173
SGTC_2824 7998404 51.95 µM -0.0755722708201791 0.465492261391119 no 1814 0.46987969901926 2534 837851
SGTC_2386 9075165 157.42 µM -0.0759161617626621 0.465356492411149 no 1815 0.469742899369057 2541 16452277
SGTC_3343 9148379 18.9835 µM -0.0779286049128839 0.464562056321349 no 1816 0.46894242258271 2591 1955036
SGTC_1785 bathophenanthroline 24 µM -0.0782431562014048 0.464437896108537 no 1817 0.46881731676727 2562 72812 An iron chelator.
SGTC_873 0591-4978 488 µM -0.078490722977018 0.464340178569737 no 1818 0.46871885472446 2625 3305145
SGTC_2125 5246583 200 µM -0.0797076229399677 0.463859885121621 no 1819 0.468234898258748 2544 835267
SGTC_1788 fluconazole 20 µM -0.0797127219811222 0.463857872711486 no 1820 0.468232870487822 2644 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_553 k007-0256 45.7 µM -0.079949446771327 0.463764446877628 no 1821 0.468138731413108 2595 6287000
SGTC_1725 st036284 20.55 µM -0.0828952544558064 0.462602022846242 no 1822 0.466967413725611 2633 707914
SGTC_750 4073-0104 132 µM -0.0830359669890408 0.462546505195004 no 1823 0.466911470415555 2570 22330957
SGTC_766 1391-0721 126 µM -0.08362561688913 0.462313868780134 no 1824 0.466677049469723 2617 1020919 YIL115C NUP159
SGTC_1594 piperine 70.1 µM -0.0839019072145796 0.462204867526408 no 1825 0.466567211585779 2573 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.0854504203620547 0.461594005399294 no 1826 0.465951655027684 2604 75037 A free radical scavenger.
SGTC_2204 7233102 200 µM -0.0867494185573318 0.461081642494718 no 1827 0.465435347058836 2555 2172480
SGTC_1186 1319-0216 26 µM -0.0879013727652839 0.460627332056248 no 1828 0.46497753276039 2684 4565136
SGTC_232 clozapine 119 µM -0.0888790111262496 0.460241809004504 no 1829 0.464589032110799 2562 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2923 7992654 58.14 µM -0.0890942782341065 0.46015692533 no 1830 0.464503492310126 2593 2985126
SGTC_2455 5377712 9.75 µM -0.0911465832736656 0.459347756436982 no 1831 0.463688059280607 2630 2243908
SGTC_3028 9087778 49.47 µM -0.0916591901547891 0.459145675426506 no 1832 0.463484411191691 2583 17217395
SGTC_795 0685-0265 78 µM -0.092482693475901 0.458821054261069 no 1833 0.463157270446362 2569 302754
SGTC_1604 st002052 72.4 µM -0.0932576076817018 0.458515611769784 no 1834 0.462849454714553 2697 6254834 YHR062C RPP1
SGTC_2374 9071832 200 µM -0.0937775450602029 0.45831068542293 no 1835 0.462642934754734 2559 17381698
SGTC_3347 9188721 44.724 µM -0.0953835602860468 0.457677766262861 no 1836 0.462005086764665 2644 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1944 st076371 56.9 µM -0.0957854435610786 0.457519403650984 no 1837 0.461845489276358 2576 24208455
SGTC_2816 7982706 58.44 µM -0.0962698021423262 0.457328550505593 no 1838 0.461653147032044 2665 2981853
SGTC_3216 9129716 49.47 µM -0.0963907618470315 0.457280889953998 no 1839 0.461605114469092 2617 8056934
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.0988510452430136 0.456311623200326 no 1840 0.460628269342136 2696 688751
SGTC_361 000s-0510 1.45 µM -0.099743088295455 0.455960252921695 no 1841 0.460274145787472 2643 660
SGTC_481 bay k-8644 50 µM -0.0997953905004546 0.455939652470596 no 1842 0.460253383815414 2583 2303 A calcium channel antagonist.
SGTC_2479 5617353 43.85 µM -0.100058009992472 0.455836215410997 no 1843 0.460149135575483 2673 2731746
SGTC_20 0481-0013 4.944 µM -0.101336545566409 0.455332685773949 no 1844 0.459641653166817 2569 182045
SGTC_1912 st060209 90.8 µM -0.103116017548433 0.45463199038909 no 1845 0.458935446312132 2647 688787
SGTC_1968 st069590 43.6 µM -0.103440454672241 0.454504253262549 no 1846 0.458806703073911 2657 6384066
SGTC_2829 7992743 58.44 µM -0.103745983448593 0.454383965016889 no 1847 0.458685467001818 2654 16462845
SGTC_3296 9122258 64.045 µM -0.10512391878862 0.453841516946985 no 1848 0.458138740004803 2678 4730474
SGTC_502 l-744,832 89.3 µM -0.105203418597665 0.453810223089936 no 1849 0.458107199064705 2616 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2729 fluphenazine 10.66 µM -0.106219882823029 0.45341013317758 no 1850 0.457703947988354 2611 3372 An atypical antipsychotic.
SGTC_2534 helenine 20.12 µM -0.106326607034785 0.453368128256475 no 1851 0.457661610941627 2600 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3328 9140624 29.0385 µM -0.107652501205739 0.452846321436989 no 1852 0.457135674501669 2668 4904392
SGTC_1287 0971-0001 34.6 µM -0.107971049016814 0.452720968761388 no 1853 0.457009328732255 2590 4665869
SGTC_937 3122-0005 46.7 µM -0.109016290658791 0.452309685844443 no 1854 0.456594784634137 2644 759535
SGTC_2946 9065502 71.43 µM -0.109062876538992 0.452291356365063 no 1855 0.456576309713954 2582 16489101
SGTC_3260 9137109 49.47 µM -0.109972745442441 0.451933383707132 no 1856 0.456215494886193 2568 17478346
SGTC_454 lyso-paf C-16 6.67 µM -0.11015955753165 0.451859890449765 no 1857 0.456141417713235 2662 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2469 5655019 90.81 µM -0.110243860821384 0.451826725452228 no 1858 0.45610798916921 2767 2788239
SGTC_1504 k297-0033 30 µM -0.1102729208399 0.451815293290116 no 1859 0.456096466154603 2570 4388117
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.110618018274306 0.451679535600609 no 1860 0.455959629329714 2657 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.111227589519584 0.45143975051975 no 1861 0.455717937048758 2598 688803
SGTC_1974 st069448 26.9 µM -0.112919729720738 0.450774211890071 no 1862 0.455047097158863 2678 6323587 YNR016C ACC1
SGTC_1547 harmine 94.2 µM -0.115237458421672 0.44986284688912 no 1863 0.454128454453923 2619 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2060 5238662 140 µM -0.115427307289729 0.449788207172444 no 1864 0.454053217763961 2701 790130
SGTC_2684 capsaicin 100 µM -0.115720227836406 0.449673047966656 no 1865 0.453937137229144 2702 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_86 0417-1630 471.922 µM -0.115743651834232 0.449663839205286 no 1866 0.453927854778677 2604 3634867
SGTC_570 0987-0065 62.6 µM -0.117062558814123 0.449145376391933 no 1867 0.453405239713067 2597 3104428
SGTC_2555 cholic acid 100 µM -0.117309332647844 0.44904837912336 no 1868 0.453307464856315 2762 6708657 Influences liver metabolism.
SGTC_930 2810-3379 265 µM -0.117539893598319 0.448957757264771 no 1869 0.453216116302684 2767 1015764
SGTC_3308 9128332 17.569 µM -0.117670252444641 0.448906520967823 no 1870 0.453164469050498 2732 17332805 YDL196W YDL196W
SGTC_1406 3909-7906 11.9 µM -0.118175880306456 0.448707796845379 no 1871 0.45296415037434 2651 X1406
SGTC_2186 6124449 200 µM -0.118180015598609 0.448706171627356 no 1872 0.452962512111507 2718 3834182 YLR033W RSC58
SGTC_1855 st056195 39.6 µM -0.118541128371881 0.448564253420301 no 1873 0.452819454539623 2701 4028379
SGTC_895 0964-0006 13.7 µM -0.121309669606293 0.447476429899709 no 1874 0.451722880672741 2589 6738897
SGTC_1929 genistein trimethyl ether 50.5 µM -0.12139141166839 0.447444317526537 no 1875 0.451690509535658 2627 136420
SGTC_1995 st072814 61.1 µM -0.122393162163693 0.447050807838442 no 1876 0.451293826800764 2633 5769371
SGTC_2801 7907800 81.82 µM -0.122710589782975 0.446926126125341 no 1877 0.451168138906664 2693 6620925
SGTC_1626 st003712 1.76 µM -0.123309170619891 0.446691025125896 no 1878 0.450931139575624 2749 24207035
SGTC_2487 5918373 44.05 µM -0.124552357679747 0.446202805968008 no 1879 0.450438973822151 2608 2876279
SGTC_1562 morin hydrate 59.1 µM -0.124691213517381 0.446148280140614 no 1880 0.450384006853938 2775 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_853 0419-0306 21 µM -0.125048056931926 0.446008159755257 no 1881 0.450242752482255 2621 762713
SGTC_1176 0848-0131 83.3 µM -0.125302295585827 0.445908332914413 no 1882 0.450142117447007 2716 6769040
SGTC_3117 9124945 49.47 µM -0.12578344037344 0.445719420740154 no 1883 0.44995167516063 2605 17592065
SGTC_1405 3909-7894 12 µM -0.128037135980459 0.444834715579539 no 1884 0.449059792312532 2725 7104060
SGTC_1007 4101-0031 70 µM -0.129824159913011 0.444133400956279 no 1885 0.448352773914939 2685 1146276
SGTC_2588 indole-3-carbinol 100 µM -0.1313188552149 0.443546944451487 no 1886 0.447761538323643 2739 3712 Induces cell cycle arrest.
SGTC_3119 9125183 49.47 µM -0.131650801325234 0.443416719282379 no 1887 0.447630250771815 2640 22695334
SGTC_2682 pyrogallin 40.03 µM -0.131657313432792 0.443414164590491 no 1888 0.447627675234401 2662 822798 An ATP competetive kinase inhibitor.
SGTC_398 bronopol 33.3 µM -0.13304632839343 0.442869309629697 no 1889 0.447078370697873 2638 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2888 9058547 12.99 µM -0.133158175280133 0.442825441259396 no 1890 0.447034143753058 2662 16476514
SGTC_2817 7995342 71.43 µM -0.13386594063144 0.442547859170635 no 1891 0.446754291631731 2645 18879975
SGTC_1937 st074714 47.2 µM -0.133944109750615 0.442517203353571 no 1892 0.446723384997442 2635 17250970
SGTC_357 1325-0123 420 µM -0.134043219795633 0.442478335565902 no 1893 0.446684199170887 2681 1098503
SGTC_402 epigallocatechin gallate 10 µM -0.134996566614705 0.442104491786195 no 1894 0.446307294463592 2655 65064 An antioxidant.
SGTC_3350 9150499 3.57 µM -0.136228641487512 0.441621424485188 no 1895 0.445820266797278 2651 4910996 YPR165W RHO1
SGTC_947 3447-0010 211 µM -0.137307907601802 0.441198341180551 no 1896 0.445393710138488 2611 748350
SGTC_429 1112-0049 25.5 µM -0.13788017034942 0.440974035546689 no 1897 0.445167561239249 2668 2836170
SGTC_1246 0422-0085 105 µM -0.138322708689086 0.440800590016866 no 1898 0.444992689539806 2706 264295
SGTC_2381 9035592 200 µM -0.139292595775582 0.440420498692977 no 1899 0.444609470280017 2690 4749657
SGTC_808 0711-0032 135 µM -0.141142962802505 0.439695506564161 no 1900 0.443878501971322 2621 4252555
SGTC_848 0368-0089 85.6 µM -0.141569384727076 0.439528458808685 no 1901 0.443710075385092 2685 762535
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.141632311091962 0.439503808763828 no 1902 0.443685221817731 2770 1273210
SGTC_1240 0356-0016 42.1 µM -0.142507887368211 0.439160845041163 no 1903 0.443339424868813 2737 4305613
SGTC_2124 5246320 200 µM -0.143587200241839 0.438738140445175 no 1904 0.442913224319353 2763 579342
SGTC_2809 7964133 12.99 µM -0.144283346227011 0.438465537250624 no 1905 0.4426383642436 2702 1253665
SGTC_2915 7971052 15.16 µM -0.145750417964143 0.437891143653933 no 1906 0.442059209264573 2644 5741558
SGTC_70 0141-0289 43.283 µM -0.145888253615937 0.437837184411985 no 1907 0.442004802316203 2781 352408
SGTC_2372 9071633 200 µM -0.146387999702962 0.437641555903255 no 1908 0.441807550054849 2658 21321366
SGTC_617 3770-0098 35 µM -0.147702469702714 0.437127071877124 no 1909 0.441288791238284 2683 5962639
SGTC_3072 9116419 49.47 µM -0.147847255599648 0.437070409109369 no 1910 0.441231657269523 2749 17170162
SGTC_3252 9135871 49.47 µM -0.148230956084755 0.436920252032403 no 1911 0.441080251123633 2817 17682838
SGTC_223 busulfan 5 mM -0.148253793678854 0.436911315070769 no 1912 0.441071239803243 2769 2478 A DNA alkylator.
SGTC_336 4111-0029 111 µM -0.148575976357514 0.436785239801124 no 1913 0.440944115333499 2724 3131175
SGTC_91 0417-1751 58.384 µM -0.14964268094635 0.436367867008104 no 1914 0.440523266385472 2637 6795624
SGTC_405 ebelactone b 50 µM -0.149701700129845 0.436344776454092 no 1915 0.440499983393881 2681 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2994 9053520 71.4286 µM -0.151859883067213 0.43550056266286 no 1916 0.439648724957904 2786 4647384
SGTC_3184 9108758 49.47 µM -0.153577517113365 0.434828887656008 no 1917 0.438971432673569 2644 902885
SGTC_1311 1190-0148 100 µM -0.15366250094851 0.434795659879668 no 1918 0.438937926725527 2799 1961333
SGTC_237 nikkomycin 200 µM -0.154895397551869 0.434313662330399 no 1919 0.438451891039256 2814 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_166 k072-0058 166.424 µM -0.15495756049831 0.434289362476211 no 1920 0.438427387453468 2677 5846229
SGTC_3283 9109332 35.8195 µM -0.155043437730596 0.434255792979391 no 1921 0.438393536484174 2644 17027281
SGTC_1043 0916-0009 19.3 µM -0.156874325753122 0.433540210182181 no 1922 0.437671947191397 2681 3101130
SGTC_2085 5307070 144.047 µM -0.157957569499665 0.43311693846814 no 1923 0.437245116760692 2663 2840351
SGTC_1018 4259-0013 28.1 µM -0.158311721445746 0.432978572101597 no 1924 0.437105586119689 2838 6801262
SGTC_1930 st074634 34.3 µM -0.158411092262387 0.432939749623074 no 1925 0.43706643688891 2679 684253 YOR116C RPO31
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.158669256683691 0.43283889222498 no 1926 0.436964730446887 2673 23665772 A membrane-active detergent.
SGTC_3354 9151612 71.43 µM -0.159227630024604 0.432620766827907 no 1927 0.436744767972969 2806 27261949
SGTC_827 3253-0474 693 µM -0.160278328289502 0.432210373192815 no 1928 0.436330914843515 2748 5402065
SGTC_3128 9127691 49.47 µM -0.160365713128621 0.432176244720145 no 1929 0.43629649849519 2852 41316314
SGTC_2100 5377183 190 µM -0.160644954181013 0.432067189486418 no 1930 0.436186523186028 2781 2844202
SGTC_1622 st003707 19.4 µM -0.160827862119724 0.431995759141456 no 1931 0.436114490043349 2808 10140899
SGTC_23 0213-0011 39.996 µM -0.161409512140897 0.431768624346695 no 1932 0.435885437650743 2808 627608
SGTC_277 nystatin 15.5 µM -0.161463374746143 0.43174759209651 no 1933 0.435864227771801 2654 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1321 1326-2144 215 µM -0.16344705186077 0.430973141845532 no 1934 0.435083229459449 2819 3513030
SGTC_2870 9038528 12.99 µM -0.163975938364591 0.430766703182143 no 1935 0.434875042901916 2842 6463316
SGTC_3075 9116269 49.47 µM -0.16443045506411 0.430589308170209 no 1936 0.434696145088318 2866 17015205 YNL244C SUI1
SGTC_2111 5486399 200 µM -0.164638203811677 0.430508229801136 no 1937 0.434614379612589 2695 689674
SGTC_2221 6807166 181.081 µM -0.164834030381236 0.430431806997697 no 1938 0.434537309012238 2708 674925
SGTC_2140 5586273 200 µM -0.16522010318105 0.430281146795504 no 1939 0.434385371330745 2687 854421
SGTC_1835 st008666 49.2 µM -0.165712946263993 0.43008883554257 no 1940 0.434191428640414 2720 690455
SGTC_2108 5365811 200 µM -0.165732064208774 0.430081375903767 no 1941 0.434183905701282 2801 780283
SGTC_3030 9087619 49.47 µM -0.167082139633642 0.429554652676719 no 1942 0.433652709487051 2725 25236973
SGTC_2091 4-phenylthiadiazole 200 µM -0.168869499624807 0.428857518710983 no 1943 0.43294964519299 2728 270010
SGTC_2797 7859098 81.82 µM -0.168997550363834 0.428807582860405 no 1944 0.43289928410656 2741 972681
SGTC_1698 5-fluorocytosine 1.055 µM -0.170344211372926 0.428282495638098 no 1945 0.432369721830749 2766 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2924 9010168 62.78 µM -0.171688582278553 0.427758427989304 no 1946 0.431841181272712 2796 2993929
SGTC_381 3461-2219 42.7 µM -0.174377736386437 0.426710515223547 no 1947 0.430784305022594 2817 2883159
SGTC_627 1391-0720 175 µM -0.174757900691481 0.426562413893536 no 1948 0.430634934784951 2801 997839
SGTC_2430 5571206 200 µM -0.175071069643079 0.426440419847357 no 1949 0.430511895123939 2834 1731771
SGTC_996 3970-0799 1.8 µM -0.175141613430467 0.426412940692748 no 1950 0.430484180396016 2784 6615648 YGL040C HEM2
SGTC_2332 7982454 138.89 µM -0.179071128961807 0.424882831428475 no 1951 0.428940925655514 2775 2981748
SGTC_2155 5570423 76 µM -0.180223632398558 0.424434273000395 no 1952 0.428488503109524 2737 797402
SGTC_2434 5670830 169.91 µM -0.18035788251808 0.424382028729389 no 1953 0.428435808471181 2816 1549830
SGTC_2961 9083290 32.55 µM -0.180688078293484 0.42425353663911 no 1954 0.428306208452699 2731 17741490
SGTC_1513 0337-0559 19 µM -0.181956779280013 0.423759910474878 no 1955 0.427808322370089 2745 775073
SGTC_1993 st073995 70.8 µM -0.182102845940545 0.423703086523963 no 1956 0.427751007670044 2752 3098394
SGTC_2023 5144124 124 µM -0.182127081689159 0.423693658304179 no 1957 0.427741498017925 2764 2830192
SGTC_683 panaxydol 45 µM -0.182653356733213 0.42348893694219 no 1958 0.427535007946058 2776 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1530 rhein 70.4 µM -0.18456864962551 0.422744061406371 no 1959 0.426783688700683 2715 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_568 1193-0097 7.48 µM -0.185152585005095 0.42251701821616 no 1960 0.426554678841812 2790 3646150
SGTC_791 1348-1292 225 µM -0.1852459102009 0.422480734307044 no 1961 0.426518080526534 2807 5437054
SGTC_506 n9-isopropylolomoucine 153 µM -0.185410128060213 0.422416889631773 no 1962 0.426453682551755 2827 6610355
SGTC_2898 9056270 58.44 µM -0.186051883243224 0.422167407395558 no 1963 0.426202037305413 2705 19154699
SGTC_864 0469-0573 172 µM -0.1865474000949 0.421974796648467 no 1964 0.426007755629969 2714 689425
SGTC_2996 9066192 71.4286 µM -0.187246436987723 0.421703108029679 no 1965 0.425733708598778 2782 6472854
SGTC_1123 mangostin 811.285 nM -0.191402237230519 0.420088682702712 no 1966 0.424105233706408 2839 5281650 An antioxidant.
SGTC_1024 4507-0395 26 µM -0.191482193568369 0.420057634736573 no 1967 0.424073914951562 2910 4201836
SGTC_1877 wortmannin 25 µM -0.191493379781798 0.420053291040831 no 1968 0.424069533369955 2867 312145 A covalent inhibitor of PI 3-kinase.
SGTC_3258 9138477 49.47 µM -0.191733008220113 0.419960243749773 no 1969 0.423975674412165 2766 4970355
SGTC_835 0312-0010 67.2 µM -0.192422311699343 0.419692613411719 no 1970 0.423705708372691 2738 1626196
SGTC_899 1083-0020 478 µM -0.192731047951605 0.419572754896451 no 1971 0.423584803273455 2918 767123
SGTC_749 1000-0129 128 µM -0.193737455466631 0.419182096207595 no 1972 0.423190731112837 2907 708470
SGTC_2810 7959871 45.46 µM -0.194530532819035 0.418874302304029 no 1973 0.422880245303215 2857 2974535
SGTC_149 3970-0822 46.1 µM -0.200063908728229 0.416728186870803 no 1974 0.420715299679373 2756 3114250 YBL034C STU1
SGTC_968 1309-0633 340 µM -0.200151988039696 0.416694045259958 no 1975 0.420680857651945 2860 3761976
SGTC_2984 9022109 38.96 µM -0.200342467488507 0.416620213098819 no 1976 0.420606375740409 2812 6459207
SGTC_103 0844-0104 51.839 µM -0.200638605867348 0.416505432087789 no 1977 0.420490584365837 2877 5375804
SGTC_1056 3448-1962 115 µM -0.200841402348914 0.416426833801119 no 1978 0.420411294041102 2860 715507
SGTC_1811 st050069 61.5 µM -0.200956378452157 0.41638227373929 no 1979 0.420366341576329 2751 3877702
SGTC_2713 st079149 53.4 µM -0.201713955656771 0.416088694517239 no 1980 0.420070175912881 2841 3103253
SGTC_1817 st052116 64.4 µM -0.202110251614304 0.415935139028272 no 1981 0.419915266810082 2905 4361398
SGTC_2822 7994718 71.43 µM -0.203416233943359 0.415429192128879 no 1982 0.419404856102049 2707 1018011
SGTC_1727 st034309 9.9045 µM -0.203418349582327 0.415428372628713 no 1983 0.419404029366951 3061 870305
SGTC_1163 k060-0048 49.9 µM -0.20367496409158 0.415328974828992 no 1984 0.419303753923074 2769 6809982
SGTC_1784 st039334 36.3 µM -0.204515936945782 0.415003268001 no 1985 0.41897516965017 3019 3496984
SGTC_2325 6158266 200 µM -0.204699078547024 0.414932345423074 no 1986 0.418903620188635 2850 3623240
SGTC_3050 9093513 49.47 µM -0.206400441802037 0.414273616083476 no 1987 0.418239062876647 2783 25236664
SGTC_2225 6654152 15.4 µM -0.207374186677368 0.41389671245755 no 1988 0.417858820233731 2776 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2028 5153890 36.43 µM -0.207653340438796 0.413788676111686 no 1989 0.417749826190781 2781 2830968 YPR165W RHO1
SGTC_2486 5283202 22.39 µM -0.208543748958971 0.413444119403185 no 1990 0.417402213361152 2837 1377751
SGTC_846 0335-0850 148 µM -0.209007894060889 0.413264538018193 no 1991 0.41722103807229 2781 6819598
SGTC_75 0159-0059 199.013 µM -0.209018925362115 0.413260270141719 no 1992 0.417216732306689 3083 5377270
SGTC_3158 9100007 49.47 µM -0.21029164642432 0.41276793875368 no 1993 0.416720027356157 2796 19297233
SGTC_3194 9111903 49.47 µM -0.210421905561013 0.412717557856952 no 1994 0.416669198597737 2962 17087251
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.210664758507428 0.412623632399139 no 1995 0.416574438034937 2932 551469
SGTC_269 exalamide 29 µM -0.211366525636164 0.412352246083783 no 1996 0.416300637663313 2803 3316 A derivative of salicylamide.
SGTC_1211 1056-0033 32.3 µM -0.211752935774046 0.41220283202339 no 1997 0.416149893813159 2814 6741922
SGTC_1637 st007924 17.4 µM -0.212306985167644 0.411988618730404 no 1998 0.415933773135746 2767 683336
SGTC_985 1493-0307 8.71 µM -0.212596037766795 0.411876872115413 no 1999 0.415821031102576 2908 3278274
SGTC_2098 5376439 882.5 nM -0.212895127293925 0.411761252785525 no 2000 0.415704381560573 2877 2844116
SGTC_2651 TUB2.036 5 µM -0.213119535917716 0.41167450795483 no 2001 0.415616863602582 2886 15992207 YFL037W TUB2
SGTC_1160 4092-0570 10.5 µM -0.213312428574695 0.411599949025502 no 2002 0.415541640019208 2780 4994975
SGTC_1839 st053978 48 µM -0.214957125478061 0.410964353119248 no 2003 0.414900373023066 2817 3788398
SGTC_1571 st070080 73.4 µM -0.216770646786229 0.410263785677121 no 2004 0.414193544258949 2938 4315245
SGTC_2951 9072950 58.06 µM -0.2182510511572 0.409692114190123 no 2005 0.413616755297534 2796 16488155
SGTC_2733 amorolfine 100 µM -0.218300806482501 0.40967290405004 no 2006 0.413597373065434 2817 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1456 k015-0012 13 µM -0.219458457428571 0.409226005426638 no 2007 0.413146468616837 2801 2989616
SGTC_2780 5215298 71.43 µM -0.220148749171581 0.408959581864944 no 2008 0.412877654813219 2929 2834131
SGTC_2841 9004761 38.96 µM -0.220592814608077 0.408788213516843 no 2009 0.412704748181236 2814 2991039
SGTC_426 0988-0037 14.6 µM -0.220752321502106 0.408726662805199 no 2010 0.412642644801057 2840 5383008
SGTC_2902 5787006 60.46 µM -0.22156245375534 0.408414082780705 no 2011 0.412327256791976 2804 591003
SGTC_1540 guanosine 70.6 µM -0.2222222332749 0.408159557630162 no 2012 0.412070443569102 2765 6802 Guanosine is a purine nucleoside
SGTC_1137 ixabepilone 100 µM -0.222515050464319 0.408046609060402 no 2013 0.411956479177601 2776 154225 A novel microtubule stabilizer.
SGTC_2621 lithochol-11-enic acid 100 µM -0.22324620769559 0.407764612671885 no 2014 0.411671945367908 2837 6708711
SGTC_1150 3909-7983 10.9 µM -0.223322730988268 0.407735101544047 no 2015 0.41164216859481 2831 23965914
SGTC_356 1634-0012 32.5 µM -0.224000400186484 0.407473781990882 no 2016 0.411378495921169 2874 735457
SGTC_389 tpck 16.7 µM -0.224005233234181 0.407471918441876 no 2017 0.411376615585895 2877 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2065 5221596 34.26 µM -0.224056535832684 0.407452137076475 no 2018 0.411356656031374 2932 788581
SGTC_1215 3852-0577 11.2 µM -0.224345749111125 0.407340626020083 no 2019 0.41124414032873 2964 2884876
SGTC_2563 tomatine 8.54 µM -0.224765892787931 0.407178645920276 no 2020 0.41108070039552 2833 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_3206 9114350 49.47 µM -0.225198814343257 0.407011756105522 no 2021 0.410912305889661 2922 17087243
SGTC_59 0330-0160 1.33 µM -0.228201717543036 0.405854613211571 no 2022 0.409744713129847 2826 4293482
SGTC_1606 st000094 49.2 µM -0.228858698189526 0.405601560627834 no 2023 0.409489371344489 2901 1242210
SGTC_354 2783-3500 4.88 µM -0.23108782135972 0.404743252477885 no 2024 0.408623288116205 2834 6740761
SGTC_3092 9117248 49.47 µM -0.231155797528877 0.404717085910899 no 2025 0.408596884261491 2816 17141857
SGTC_346 4513-0042 7.16 µM -0.232119224216818 0.404346272854607 no 2026 0.408222706920944 2818 2827372
SGTC_2894 9048625 32.47 µM -0.233040199718646 0.403991879136077 no 2027 0.407865095060864 2974 4092861
SGTC_1002 4049-0206 172 µM -0.23403689481767 0.403608437100462 no 2028 0.407478167998513 2815 4662749
SGTC_1524 corynanthine 62.1 µM -0.23526496155802 0.403136110690051 no 2029 0.40700154427766 3012 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.23658050833661 0.402630295361974 no 2030 0.406491121534936 2816 2724278 An inhibitor of dopamine biosynthesis.
SGTC_842 0271-0008 11.1 µM -0.23709699470571 0.402431755722585 no 2031 0.406290771891675 2934 1221709
SGTC_2776 terbinafine 19.92 µM -0.237250307006597 0.402372826638846 no 2032 0.406231305410107 2828 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3243 9134147 49.47 µM -0.238477313843925 0.401901278580478 no 2033 0.405755454387015 2884 24282180
SGTC_3116 9124943 49.47 µM -0.238758604161973 0.401793196663941 no 2034 0.405646385519497 2850 41905195 YPL160W CDC60
SGTC_1706 st031321 9.9705 µM -0.239262109861694 0.401599750318481 no 2035 0.40545117208151 2931 6103185
SGTC_3329 9141233 27.5565 µM -0.239428099583678 0.401535982528934 no 2036 0.405386821607714 2993 4909101 YNL103W MET4
SGTC_669 0108-0021 26.2 µM -0.239877908572848 0.401363193899863 no 2037 0.405212453661174 2864 17201
SGTC_1342 1486-1464 234 µM -0.240308811914578 0.401197685731439 no 2038 0.405045432110755 2824 3253938
SGTC_2746 daunorubicin 9.88 µM -0.240886207503062 0.400975938302106 no 2039 0.404821656122339 2812 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_531 3788-1495 174 µM -0.240917112944328 0.400964070038237 no 2040 0.404809679256732 2787 2896655
SGTC_1485 3909-9022 254 µM -0.241143563556945 0.400877111583129 no 2041 0.404721924986208 2829 714516
SGTC_1450 4112-4260 37.6 µM -0.241261599969932 0.400831786807326 no 2042 0.404676185347716 2977 1633175
SGTC_225 nsc-122657 1.016 µM -0.242081015947521 0.400517176281753 no 2043 0.404358693927837 2960 275685
SGTC_1769 st044406 64.4 µM -0.246322117276832 0.398889863012695 no 2044 0.402716445094378 2835 670903
SGTC_782 0083-0095 30.5 µM -0.246827726058285 0.39869597720102 no 2045 0.4025207759739 2800 3591729 An indicator and reagent.
SGTC_1998 st075797 76.8 µM -0.246835923492957 0.398692833936355 no 2046 0.402517603791668 2879 24208315
SGTC_2856 9022925 19.48 µM -0.251269137577854 0.396993908367028 no 2047 0.400803017254643 3006 4944862
SGTC_1092 toremifene 6.32 µM -0.252374647219927 0.39657055063952 no 2048 0.400375747307357 2842 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.252448735917458 0.396542182537642 no 2049 0.400347116920644 2864 4174840
SGTC_2033 5192550 145 µM -0.253228272454225 0.396243736063781 no 2050 0.400045910037535 2887 182073
SGTC_1640 st009078 66.4 µM -0.254233352523284 0.395859029730408 no 2051 0.399657642647115 2985 690618
SGTC_1275 0867-0008 21.1 µM -0.255354995192315 0.395429827436129 no 2052 0.399224463688993 2839 3422836
SGTC_2313 7726885 200 µM -0.256036497773477 0.395169108889267 no 2053 0.398961327604491 2963 726423
SGTC_3339 9145883 14.936 µM -0.257863638245665 0.394470342048287 no 2054 0.398256074248554 3001 2030670
SGTC_1692 fluoroquinolonic acid 71 µM -0.258046229371471 0.394400530992784 no 2055 0.398185614580664 2984 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2921 7974240 10.71 µM -0.259020726028481 0.394028003807992 no 2056 0.397809624508658 2993 2979074 YDR527W RBA50
SGTC_1210 3013-0140 750 nM -0.259075967928588 0.394006889027164 no 2057 0.397788313363795 3006 905973
SGTC_632 0781-2353 4.65 µM -0.259734972794674 0.393755025585393 no 2058 0.397534106904324 2948 6811515 YHR007C ERG11
SGTC_379 3970-0972 5.9 µM -0.259839702293082 0.39371500336673 no 2059 0.397493712246006 2911 2898042 YBL034C STU1
SGTC_2784 7567673 72.73 µM -0.261040616354076 0.393256156231956 no 2060 0.397030592738753 2811 3471247
SGTC_1399 3562-5772 25 µM -0.261854699126693 0.392945194466399 no 2061 0.396716733045493 2820 23847490
SGTC_1729 st035615 45.989 µM -0.2620650312877 0.392864863289568 no 2062 0.396635652911046 2985 17385451
SGTC_1481 3346-2004 36 µM -0.263394468557408 0.392357223237408 no 2063 0.396123276791575 2893 2770522
SGTC_1633 st005664 67.9 µM -0.263604080068497 0.392277200649991 no 2064 0.396042507131445 2839 2063822
SGTC_2348 9022543 33.42 µM -0.263783876410129 0.392208564115349 no 2065 0.395973229714213 3012 3162678 YDL140C RPO21
SGTC_1143 3454-2408 5.08 µM -0.264400630705423 0.391973146122919 no 2066 0.395735612790515 2854 X1143
SGTC_2709 st078560 56 µM -0.264492684373047 0.391938012197796 no 2067 0.395700150595501 3036 17250903
SGTC_147 4466-0538 29.23 µM -0.264871061925971 0.391793606909398 no 2068 0.395554395799748 3094 6742687 YHR072W ERG7
SGTC_1552 6-methylflavone 10.6 µM -0.266836527098163 0.391043740377628 no 2069 0.394797514511594 2902 689013
SGTC_1165 k072-0275 30.3 µM -0.269095012939991 0.390182580303127 no 2070 0.393928284019151 2966 6153523 YGL055W OLE1
SGTC_3197 9113331 49.47 µM -0.270122863060415 0.389790839397472 no 2071 0.393532866754168 3098 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_3269 9137823 49.47 µM -0.270291155834005 0.389726709216839 no 2072 0.393468134427616 2853 17682936
SGTC_1934 st074720 32.6 µM -0.271483061638117 0.389272603812136 no 2073 0.393009762776573 2871 17250992
SGTC_2723 salbutamol 83.58 µM -0.271626480486028 0.389217972697223 no 2074 0.392954618121513 2981 9884233 β2-adrenoceptor agonist
SGTC_1847 st056231 15 µM -0.272157688087171 0.389015644154498 no 2075 0.392750387120606 2883 5393180
SGTC_1978 st071761 42 µM -0.272355463280589 0.388940322407814 no 2076 0.392674356919626 2909 5147680
SGTC_299 1273-0059 1.44 µM -0.273337797658388 0.388566266914243 no 2077 0.392296781421012 2985 2848077
SGTC_1671 st016596 74.5 µM -0.275507266516866 0.387740538149116 no 2078 0.391463271943145 2932 2829167
SGTC_2864 9034755 47.6 µM -0.275558520027897 0.387721036500751 no 2079 0.391443586362857 2864 4930451
SGTC_2354 9060492 162 µM -0.276954420755513 0.387190013845109 no 2080 0.390907552282472 3038 6471895
SGTC_1106 tegaserod maleate 11.7 µM -0.277033817625923 0.387159816357173 no 2081 0.390877069636184 2941 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1142 3253-1408 9.78 µM -0.277072709196239 0.387145024742135 no 2082 0.390862138335343 2918 256655
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.277474029026841 0.38699240050877 no 2083 0.390708072518695 2898 16623 A steroid.
SGTC_1080 nisoldipine 24.4 µM -0.278720632221345 0.386518421688394 no 2084 0.390229613753831 2861 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_3046 9092212 49.47 µM -0.278722743215537 0.386517619197405 no 2085 0.39022880367394 2896 25236637
SGTC_282 k297-0036 65.7 µM -0.279099907610507 0.386374248562313 no 2086 0.390084077015241 3045 5061378
SGTC_1149 3909-7961 23.3 µM -0.279396603600294 0.386261477096461 no 2087 0.389970238640107 2916 735261
SGTC_2292 7671323 168.05 µM -0.279432292542619 0.386247912699 no 2088 0.389956545894815 3052 937504
SGTC_2260 7964312 200 µM -0.279587149743 0.386189057294561 no 2089 0.389897133550105 3064 231951
SGTC_2757 clomiphene 4.22 µM -0.279870899256917 0.386081221560276 no 2090 0.389788277196544 3126 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2160 5660466 132.927 µM -0.280127796228379 0.385983598415843 no 2091 0.389689729884108 2930 2859134
SGTC_102 gallobenzophenone 83.616 µM -0.280347221929961 0.385900220405209 no 2092 0.389605562404388 3077 70837
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.281533157488872 0.385449676507732 no 2093 0.389150750034063 2905 165521
SGTC_105 0111-0055 734.78 µM -0.281640285348663 0.38540898560492 no 2094 0.389109673418388 2989 5179370
SGTC_962 1254-0300 21.5 µM -0.281827262917286 0.385337968016092 no 2095 0.389037982565729 2872 7340576
SGTC_19 0279-0214 38.434 µM -0.282009664676166 0.385268692110454 no 2096 0.388968049808037 2909 3566274 YBR002C RER2
SGTC_1462 k081-0014 26.5 µM -0.282563188315313 0.385058487109921 no 2097 0.388755851107694 2919 3270634
SGTC_258 haloperidol 50.781 µM -0.282668966678447 0.385018320777795 no 2098 0.388715303712809 2945 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3102 9121669 49.47 µM -0.282695306355989 0.385008319224431 no 2099 0.388705207268374 2921 41905072
SGTC_1226 3909-7979 35.4 µM -0.282896727086607 0.384931839413822 no 2100 0.388628001777543 3013 6615510
SGTC_2969 9091408 28.7 µM -0.283351004624926 0.384759365860397 no 2101 0.388453891265146 2890 4286311
SGTC_3224 9130643 49.47 µM -0.28359631562641 0.384666239191774 no 2102 0.388359880471109 3103 17644395
SGTC_1776 st049249 45.9 µM -0.284084669488051 0.384480866717065 no 2103 0.388172747579563 2959 1822314
SGTC_2088 5278280 127.392 µM -0.284171563343177 0.384447885759881 no 2104 0.388139453340165 3001 791502
SGTC_3270 9137563 49.47 µM -0.284277295984501 0.384407755583998 no 2105 0.388098941942458 3010 17015724
SGTC_3115 9123671 49.47 µM -0.28504042361568 0.384118151932158 no 2106 0.387806586186204 2928 3286988
SGTC_548 1436-0017 110 µM -0.286925172310934 0.383403175397734 no 2107 0.38708480788958 3048 9677137
SGTC_3019 9081971 49.47 µM -0.288366081355581 0.382856836312335 no 2108 0.38653326430842 3076 16451803
SGTC_2657 nystatin 74.44 µM -0.288449304470583 0.382825288311114 no 2109 0.386501415591324 2975 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1796 st049173 110.4 µM -0.289208848099288 0.38253739844249 no 2110 0.386210780618317 3021 94134
SGTC_1611 st001856 99.4 µM -0.289343661223213 0.382486306993495 no 2111 0.386159201823102 2936 647478
SGTC_2892 9047358 58.44 µM -0.289426500761209 0.38245491349757 no 2112 0.386127508847596 2964 6466771
SGTC_2740 felodipine 17.08 µM -0.291134738833367 0.381807719211702 no 2113 0.385474136166779 3019 3333 L-type calcium channel blocker
SGTC_159 3970-0959 50 µM -0.292363428010215 0.38134241402967 no 2114 0.385004383734723 3007 6615653
SGTC_1719 st032227 49.2 µM -0.294272840976376 0.380619658905693 no 2115 0.384274712046963 2934 3125804
SGTC_779 1360-0071 233 µM -0.295203499268405 0.38026753491807 no 2116 0.383919214511717 3121 7566
SGTC_2326 6164455 177.58 µM -0.295396783675157 0.380194416237424 no 2117 0.383845394999273 2996 2888790
SGTC_3188 9110789 49.47 µM -0.296176101647184 0.37989964697243 no 2118 0.383547799322401 3100 849217
SGTC_727 3032-0951 202 µM -0.296404696672192 0.379813196405096 no 2119 0.383460519487254 2982 3652836
SGTC_1109 tnp00067 928.257 nM -0.296502550917935 0.379776191507689 no 2120 0.383423159578383 2953 676295
SGTC_2239 6685329 187.64 µM -0.297385280694972 0.379442425183846 no 2121 0.383086189978534 3060 805680
SGTC_2201 6605497 169.863 µM -0.297407771830881 0.379433922299959 no 2122 0.383077605460161 2956 670741
SGTC_248 streptozotocin 5.23457 mM -0.298920728866608 0.378862075591598 no 2123 0.38250026523574 3032 5300 DNA alkylating agent.
SGTC_3114 9122766 49.47 µM -0.299105783422009 0.378792149382471 no 2124 0.382429666821893 2992 17176985
SGTC_1753 st043925 64 µM -0.299351396216652 0.378699346275541 no 2125 0.382335971442019 3045 670181
SGTC_2945 9067681 61.76 µM -0.299723524341227 0.378558753547616 no 2126 0.382194026630276 2891 16456930
SGTC_3039 9090270 49.47 µM -0.30062324165185 0.37821890020361 no 2127 0.381850903274325 3059 17173750
SGTC_3202 9113761 49.47 µM -0.301218232106978 0.377994204121085 no 2128 0.381624043935638 3090 4798415
SGTC_1125 tnp00248 1.32998 µM -0.301377561599973 0.377934040892188 no 2129 0.381563301315508 3095 24207736
SGTC_1624 st003710 6.25 µM -0.301539167601656 0.377873021071929 no 2130 0.381501693780936 3090 24207033
SGTC_2916 7875993 68.79 µM -0.301687365288424 0.377817066693474 no 2131 0.381445200410797 2985 1299250
SGTC_286 k060-0067 22.9 µM -0.303137092137731 0.377269834778729 no 2132 0.380892693883698 2969 5985051
SGTC_358 0075-0058 9.45 µM -0.303745755865133 0.377040154368388 no 2133 0.380660797871631 2942 1069125
SGTC_1283 0922-0125 16.4 µM -0.304097350752966 0.37690749918749 no 2134 0.380526862560208 3037 3360884
SGTC_858 0438-0351 2.77 µM -0.304185957557571 0.376874070527435 no 2135 0.38049311125634 2963 2799119
SGTC_1074 carmofur 3.8 µM -0.30465110734097 0.376698598767724 no 2136 0.380315945529256 2952 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_886 0866-0150 153 µM -0.305318092848895 0.376447031536732 no 2137 0.380061948653881 3121 271463
SGTC_2722 naftopidil 47.16 µM -0.306466340170796 0.376014069536973 no 2138 0.379624802151861 3047 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2263 7948595 193.29 µM -0.307171666290056 0.375748194212686 no 2139 0.379356355347164 2918 2971371
SGTC_1820 st053765 18.6 µM -0.307173108031782 0.375747650803105 no 2140 0.379355806680426 3003 3690829
SGTC_1410 3909-8106 77.9 µM -0.30864510294111 0.375192967190746 no 2141 0.378795753795074 3034 1039210
SGTC_2182 6325192 200 µM -0.30966713822444 0.374807991019869 no 2142 0.378407047525253 2968 736248
SGTC_2014 4013930 200 µM -0.31121264571539 0.374226072434869 no 2143 0.377819485084737 3011 64556
SGTC_1795 st049545 62.3 µM -0.311388248787293 0.374159971997505 no 2144 0.377752743137042 3086 5291882
SGTC_2232 chlorophetanol 41.5365 µM -0.311541878151885 0.374102145928146 no 2145 0.377694355790288 3031 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_374 0880-0231 82.3 µM -0.313321412568268 0.373432536201283 no 2146 0.377018241840604 3027 6833587
SGTC_1953 st076800 12.1 µM -0.313525402945156 0.373355802321312 no 2147 0.376940762047394 2981 297591
SGTC_370 0180-0345 38.7 µM -0.313618270210786 0.373320870642575 no 2148 0.376905490767202 2873 3989527
SGTC_3056 9094900 49.47 µM -0.313715195378351 0.373284413709322 no 2149 0.376868679378637 3002 25236784
SGTC_2480 5767542 37.17 µM -0.313811563471214 0.373248167435852 no 2150 0.376832080672175 2991 2867358
SGTC_3155 9099265 49.47 µM -0.313840361828811 0.373237335923696 no 2151 0.376821143837096 3069 25236499
SGTC_716 1683-5115 658 µM -0.314362922049276 0.373040810270047 no 2152 0.376622706817633 2941 723597
SGTC_2931 9014674 55.67 µM -0.315365102878094 0.37266400024923 no 2153 0.376242229908767 2944 2996810
SGTC_2532 xanthone 78.9 µM -0.315788838075876 0.372504716654532 no 2154 0.376081395426694 3065 7020 An insecticide.
SGTC_3037 9091026 49.47 µM -0.317038690033214 0.372035019878276 no 2155 0.375607122494483 3061 25236398 YIL048W NEO1
SGTC_1216 1165-0504 9.65 µM -0.317450081332237 0.371880459839591 no 2156 0.375451055668432 3085 6304004
SGTC_2040 5100729 123 µM -0.317928272630849 0.371700828934826 no 2157 0.37526967297812 2966 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_90 0870-0863 4.608 µM -0.31811824048534 0.371629475918034 no 2158 0.375197623942279 2923 1738164
SGTC_2598 perillyl alcohol 100 µM -0.318910393232852 0.371331986361095 no 2159 0.374897231429767 3129 10819 An apoptosis inducer.
SGTC_2320 7373003 200 µM -0.320248386014651 0.370829683535605 no 2160 0.37439002313725 3036 5415828
SGTC_2401 5128683 200 µM -0.320513389104756 0.3707302234287 no 2161 0.374289591125928 2991 708373
SGTC_3162 9099653 49.47 µM -0.320935663909917 0.370571754458392 no 2162 0.374129573231631 3101 25237511
SGTC_1803 st050068 52.4 µM -0.323970823674079 0.369433383958679 no 2163 0.372980061651356 3053 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1282 0886-0010 32.4 µM -0.325231339379301 0.368960949048532 no 2164 0.372502995729368 3154 2836211 YNL267W PIK1
SGTC_676 falcarinol 140 µM -0.325295718464202 0.36893682539934 no 2165 0.372478635494198 3169 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_495 decylubiquinone 155 µM -0.32530371155087 0.368933830325714 no 2166 0.372475611046438 3041 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_3139 9095020 49.47 µM -0.325618030122476 0.368816058950063 no 2167 0.37235668449298 2863 25236292
SGTC_1397 3532-0190 20.1 µM -0.325707381879629 0.368782582172949 no 2168 0.372322879305217 2914 5322280
SGTC_3015 9080845 49.47 µM -0.326810445154054 0.368369387513952 no 2169 0.37190562938742 3106 5296973
SGTC_1617 st002906 78 µM -0.327109621938505 0.368257345589596 no 2170 0.371792487272497 2958 5150859
SGTC_2120 5538279 151.968 µM -0.327399744886058 0.368148705033437 no 2171 0.371682779694961 3010 2058197
SGTC_1825 st052143 62.6 µM -0.328064382589272 0.367899861995998 no 2172 0.371431491772648 3157 674173
SGTC_485 niflumic acid 177 µM -0.329495702248267 0.367364158483334 no 2173 0.370890520937266 3097 4488 A COX2 inhibitor.
SGTC_1625 st003711 30.1 µM -0.330433381320659 0.367013350868029 no 2174 0.370536261015889 3192 24207034 YER133W GLC7
SGTC_2623 humulene 100 µM -0.333046216721728 0.366036414655 no 2175 0.369549698359043 3070 6187145 An anti-inflammatory.
SGTC_1381 2324-0066 62.1 µM -0.333109404087991 0.366012799692649 no 2176 0.369525850476455 3116 10885928
SGTC_2335 9018011 154.17 µM -0.335269848246719 0.365205684579863 no 2177 0.368710768209254 3081 6458208
SGTC_1499 4480-0877 67.3 µM -0.336815012811512 0.364628796049282 no 2178 0.368128177545605 2996 2861909
SGTC_551 k048-0028 34.9 µM -0.336993675716868 0.364562111837497 no 2179 0.36806083380117 3145 6836383
SGTC_2241 6772625 37.8075 µM -0.340751630747958 0.363160443763152 no 2180 0.366645283242068 2984 2285411
SGTC_3345 9148410 3.559 µM -0.341336244308556 0.362942554630164 no 2181 0.366425232752221 3138 4903596
SGTC_219 mitoxanthrone 164.414 µM -0.341842633582965 0.362753856028877 no 2182 0.366234661628932 3050 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2794 7785382 27.27 µM -0.34227674781933 0.362592116197477 no 2183 0.366071316264296 3097 2205081
SGTC_798 1287-0182 476 µM -0.34231126005617 0.362579258874797 no 2184 0.36605833129051 3192 1649755
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.344562701476642 0.361740833566784 no 2185 0.36521157516821 3152 756377
SGTC_774 k060-0086 136 µM -0.346398116699359 0.361057824808738 no 2186 0.364521770132341 3199 5911235
SGTC_2490 carminic acid 95.39 µM -0.348686333080036 0.360206936465387 no 2187 0.363662402853714 2986 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_8 0354-0001 70 µM -0.349535735777134 0.359891256368186 no 2188 0.3633435736409 3054 4993152
SGTC_1270 0831-1170 17.3 µM -0.350263386265845 0.359620901392965 no 2189 0.363070520227092 3021 6764716
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.353542773846765 0.358403334369984 no 2190 0.361840783778313 3046 688669
SGTC_911 3456-4043 236 µM -0.353711973283326 0.358340553120198 no 2191 0.361777374295387 3104 914281
SGTC_2215 7188065 200 µM -0.354896251763228 0.357901235281232 no 2192 0.361333658301648 3146 940217
SGTC_2914 7968218 45.32 µM -0.354985946840494 0.357867969811731 no 2193 0.361300059655864 3117 2977111
SGTC_1498 4478-3555 97.6 µM -0.355230641329418 0.357777224757036 no 2194 0.36120840562423 3098 3437919
SGTC_148 3253-0744 288.01 µM -0.35535274800905 0.357731944449117 no 2195 0.361162671694926 3038 6893655
SGTC_935 2996-0153 430 µM -0.355478469516816 0.357685325761477 no 2196 0.361115585938514 3167 23738523
SGTC_1810 st050138 53 µM -0.356586999998048 0.357274364452969 no 2197 0.36070050551445 3164 3444541
SGTC_514 4466-0038 2.65 nM -0.356837279058469 0.357181602327826 no 2198 0.360606813194065 3053 5722064
SGTC_2966 9084041 48.03 µM -0.357600877841477 0.356898638239725 no 2199 0.360321010638088 2943 17741380
SGTC_33 0986-0033 35.816 µM -0.358106043377107 0.356711484092404 no 2200 0.360131978304658 3076 2848082
SGTC_311 1315-0136 58 µM -0.358824062946137 0.356445530963808 no 2201 0.359863355099192 3213 6759207
SGTC_2876 9059903 25.97 µM -0.360854173738136 0.355693959670517 no 2202 0.359104231302076 3098 6916095
SGTC_1472 k841-0093 193 µM -0.362759446962605 0.354989114607018 no 2203 0.358392293925335 3165 X1472
SGTC_137 0438-0332 85.389 µM -0.364002005172378 0.35452970425757 no 2204 0.357928256020332 3153 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1569 carminic acid 40.6 µM -0.364397253261937 0.354383613719029 no 2205 0.357780693136091 3213 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_475 α-linolenic acid 10 µM -0.365253933109796 0.354067043573414 no 2206 0.357460931171201 3272 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1206 3978-0017 132 µM -0.365438808003651 0.353998739707716 no 2207 0.357391938393563 3289 3873677
SGTC_1909 st060837 51.5 µM -0.367234799404633 0.353335437654133 no 2208 0.356721941896212 3069 678937
SGTC_729 4092-0585 94.1 µM -0.368234899835512 0.35296626979731 no 2209 0.356349044734501 3033 2169061
SGTC_1739 st037196 92.5 µM -0.368766346111039 0.352770152892844 no 2210 0.356150945673458 3232 612214
SGTC_2441 5730946 39.09 µM -0.369782747330307 0.352395184526129 no 2211 0.355772185568875 3192 1774275
SGTC_458 nppb 133 µM -0.37008128497264 0.352285075947183 no 2212 0.355660963074918 3241 4549 A chloride channel blocker.
SGTC_1683 st010134 710 nM -0.371368828672427 0.351810337713602 no 2213 0.355181419653 3029 3818134
SGTC_2016 5121758 140 µM -0.371748991968847 0.351670209474401 no 2214 0.355039872296286 3040 2795203
SGTC_2448 5185112 27.17 µM -0.373972014628298 0.350851207017613 no 2215 0.354212568546165 3178 5718189
SGTC_2153 5569715 200 µM -0.374300405733699 0.350730280308062 no 2216 0.354090415125196 3111 2054701
SGTC_2009 4012297 12.05 µM -0.374542059173952 0.350641303525231 no 2217 0.354000535572578 3158 45595307
SGTC_2815 7968870 71.43 µM -0.374689121132993 0.350587159330012 no 2218 0.353945841954359 3047 2977326 YHR190W ERG9
SGTC_1983 st071813 46.9 µM -0.375107655113841 0.350433083167506 no 2219 0.353790202032941 3122 11838595
SGTC_3242 9133940 49.47 µM -0.375430339146637 0.350314309329551 no 2220 0.353670222439847 3194 17248444
SGTC_1261 0712-0010 12.7 µM -0.377139879695542 0.349685304486236 no 2221 0.353034827950528 3244 2840123
SGTC_435 c-PAF 6.7 µM -0.377164418502355 0.349676278726279 no 2222 0.35302571045265 3201 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_216 k038-0035 28.382 µM -0.377510442934723 0.349549014534157 no 2223 0.352897152591984 3149 4444231 YPR107C YTH1
SGTC_1991 st073000 8.92 µM -0.378810734697359 0.349070931979274 no 2224 0.352414207656463 3257 4301969 YIL048W NEO1
SGTC_3215 9129942 49.47 µM -0.379895538376671 0.348672261809491 no 2225 0.352011479682042 3200 17682944
SGTC_832 4083-0019 164 µM -0.380177368834942 0.348568715184482 no 2226 0.351906878663481 3199 1990758
SGTC_1952 st077036 64.1 µM -0.380820327958567 0.348332529415637 no 2227 0.351668287155949 3088 2937007
SGTC_2992 9074591 71.4286 µM -0.380994957287988 0.348268390911559 no 2228 0.351603495180531 3194 17741321
SGTC_868 0527-0199 213 µM -0.382099296693047 0.347862885611784 no 2229 0.351193856735185 3101 2849450
SGTC_921 1561-0023 372 µM -0.382120850335477 0.347854973002134 no 2230 0.351185863446804 3046 24050882
SGTC_1650 st011916 45.8 µM -0.384015128174903 0.347159819253763 no 2231 0.350483617457656 3219 242528
SGTC_1301 naphtanilide LB 4.81 µM -0.38427720785847 0.347063682824062 no 2232 0.350386499536865 3199 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1372 2752-0194 270 µM -0.385938653912798 0.346454458093286 no 2233 0.349771051247027 3103 823334
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.388511813070849 0.345511707218314 no 2234 0.348818656871593 3072 5355888
SGTC_588 3970-1144 52.9 µM -0.388842504195444 0.345390618322788 no 2235 0.348696328221321 3179 1888707
SGTC_3307 9126885 69.2785 µM -0.389013223680233 0.345328112302055 no 2236 0.348633182139975 3073 24824909
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.390968962627591 0.344612353259539 no 2237 0.3479100888942 3223 688664
SGTC_2304 7443016 91.4 µM -0.394550535172553 0.343303016274988 no 2238 0.346587312486403 3064 939854
SGTC_164 4100-3994 89.624 µM -0.396362323180606 0.342641384524264 no 2239 0.345918878298599 3231 4615967
SGTC_456 gingerol 170 µM -0.396491266122262 0.342594315293469 no 2240 0.345871324847807 3283 442793 A herb.
SGTC_2425 5628681 7.85 µM -0.396928201678371 0.342434834855595 no 2241 0.345710203487948 3169 5714958
SGTC_875 0709-0210 25.7 µM -0.397329057152199 0.342288548266622 no 2242 0.345562411346791 3238 6251364
SGTC_1101 ebselen 5.29 µM -0.398909378164741 0.341712062950315 no 2243 0.344979989387281 3250 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_366 0181-0206 4.31 µM -0.399698596527078 0.34142430203095 no 2244 0.344689262978556 3299 274874
SGTC_650 1328-0195 38 µM -0.399736293123295 0.341410559588294 no 2245 0.344675378879212 3208 2780821
SGTC_2690 usnic acid 100 µM -0.399975624441159 0.34132331531957 no 2246 0.344587235223912 3348 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2266 7929956 200 µM -0.400264930865534 0.341217864774481 no 2247 0.344480697433269 3112 2967153
SGTC_1970 st070122 35.8 µM -0.400715781213082 0.341053557107048 no 2248 0.344314695296918 3271 102928
SGTC_1981 st071826 47 µM -0.401175811288302 0.340885935048568 no 2249 0.344145344114406 3166 11838600
SGTC_3104 9120930 49.47 µM -0.403350530197676 0.340093954116604 no 2250 0.343345186944737 3197 17014836
SGTC_2691 st077356 60.2 µM -0.404329457674615 0.33973768189216 no 2251 0.342985233168416 3269 2839272
SGTC_217 ketoconazole 989 nM -0.404522789733464 0.339667337268839 no 2252 0.342914161381937 3187 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2896 9052656 71.43 µM -0.404642745412417 0.339623693734567 no 2253 0.34287006665561 3198 6469436
SGTC_264 promethazine 12.5 mM -0.405544631248592 0.339295629057931 no 2254 0.342538609374822 3241 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_3324 9138759 60.749 µM -0.405638107162704 0.339261633771046 no 2255 0.342504262429484 3232 45595710
SGTC_2196 6573537 42.6665 µM -0.405731750115221 0.339227579047534 no 2256 0.342469855413092 3233 2903087
SGTC_1427 4048-4900 550 nM -0.406084544008996 0.339099291828899 no 2257 0.34234024089932 3230 24132586
SGTC_657 3534-0529 86.7 µM -0.406502408251894 0.338947367067986 no 2258 0.342186743923035 3243 1049549
SGTC_3042 9091578 49.47 µM -0.40730457720679 0.338655792348181 no 2259 0.341892150708529 3221 25236497
SGTC_1888 azatryptophan 97.5 µM -0.407532296811201 0.338573037769302 no 2260 0.341808539160866 3202 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_624 k048-0052 28 µM -0.407585772086557 0.33855360568478 no 2261 0.341788905829778 3158 6835531
SGTC_130 0136-0219 337.655 µM -0.408333099325027 0.338282083571588 no 2262 0.341514571057769 3090 234244
SGTC_213 1246-0773 967 nM -0.409448536572933 0.337876974588828 no 2263 0.341105263302593 3161 6251622
SGTC_3317 9138495 8.753 µM -0.410075056562826 0.337649514838119 no 2264 0.340875444825037 3154 17020139
SGTC_2405 ticlatone 3.52 µM -0.410521838401647 0.33748734571365 no 2265 0.340711593498523 2930 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.41261862006445 0.3367266770682 no 2266 0.339943028456455 3184 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3246 9135460 32.98 µM -0.413203436945126 0.336514636615504 no 2267 0.339728785116846 3202 41446951
SGTC_2970 9090938 41.86 µM -0.414130099564858 0.336178757618182 no 2268 0.339389415139666 3312 17217104
SGTC_684 1140-0066 328 µM -0.415699553239586 0.335610190305659 no 2269 0.338814934104826 3205 6813534
SGTC_763 3453-1109 128 µM -0.415939221776349 0.335523398458677 no 2270 0.338727239054839 3286 1560353
SGTC_2427 5545055 42.75 µM -0.416201527313998 0.335428419068327 no 2271 0.338631271114136 3123 5372858
SGTC_2112 5488546 200 µM -0.417827934044205 0.334839741116575 no 2272 0.338036462835198 3116 600757
SGTC_316 k060-0003 58.6 µM -0.41833552634289 0.334656101054744 no 2273 0.337850909222953 3241 6152314
SGTC_2199 6590217 200 µM -0.418556065620696 0.33457632523257 no 2274 0.33777030195386 3161 703109
SGTC_3232 9132874 49.47 µM -0.419140005112504 0.334365132476816 no 2275 0.33755690757786 3173 3784940
SGTC_3262 9137218 49.47 µM -0.419475659848086 0.334243760315081 no 2276 0.337434269815021 3151 17650664
SGTC_1521 st012942 49.4 µM -0.419769412722405 0.334137554010842 no 2277 0.337326955851373 3319 24207259
SGTC_2545 solidagenone 89.61 µM -0.420081341102616 0.334024790892812 no 2278 0.337213016487251 3035 6708572 An anti ulcer agent
SGTC_67 0335-0847 266 µM -0.420403625014643 0.333908299953327 no 2279 0.33709531019624 3396 4552207 YOR254C SEC63
SGTC_1475 4092-1048 11.7 µM -0.42088486827733 0.333734382249324 no 2280 0.336919577590598 3229 2881759
SGTC_2839 9003951 25.97 µM -0.421054924222841 0.333672933845262 no 2281 0.336857487828538 3252 2990634
SGTC_296 1222-0039 74.9 µM -0.42322037738613 0.332890854630986 no 2282 0.336067240366144 3181 5984176
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.423569216378974 0.332764935122094 no 2283 0.335940004781813 3271 61125 An anti-inflammatory.
SGTC_1948 st076329 66.6 µM -0.423717371197422 0.332711461766087 no 2284 0.33588597245871 3153 24208413
SGTC_692 k241-0027 77.8 µM -0.424626089124198 0.332383553686394 no 2285 0.335554635670645 3309 3600480
SGTC_2297 7971671 152.32 µM -0.427155344752154 0.331471555429354 no 2286 0.334633092045499 3324 909016
SGTC_2764 methyldopa 94.69 µM -0.432503911865105 0.329546263521491 no 2287 0.332687604841785 3338 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2597 laccaic acid a 100 µM -0.433203998550498 0.329294590150557 no 2288 0.332433287124556 3260 5491415 A textile dye.
SGTC_602 3130-1533 38.1 µM -0.435384786827666 0.328511117065703 no 2289 0.33164157552644 3270 720941
SGTC_607 4491-0986 66.8 µM -0.436686133687643 0.328043952021503 no 2290 0.331169493383731 3292 698981 YDR232W HEM1
SGTC_3016 9080866 49.47 µM -0.438896613724846 0.327251037607017 no 2291 0.330368225248937 3170 17066299
SGTC_452 diindolylmethane 8 µM -0.439442390430498 0.327055383504999 no 2292 0.330170508299604 3260 3071 Inhibits expression of several cancer promoting factors.
SGTC_266 formosanin C 406 nM -0.439761167486212 0.326941127910924 no 2293 0.330055047788663 3249 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_57 miconazole 162.5 nM -0.441039261725028 0.326483198278935 no 2294 0.329592286841036 3228 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.441918930788475 0.32616817259402 no 2295 0.329273935596082 3238 1241132 A phosphatase inhibitor.
SGTC_128 0906-2981 13.371 µM -0.442355908239407 0.326011729008204 no 2296 0.329115839934069 3326 6740226
SGTC_2553 4-methylesculetin 85.09 µM -0.444341319171199 0.325301312152069 no 2297 0.328397916067197 3239 5319502
SGTC_1315 1237-0019 3.69 µM -0.448385361960988 0.323856242818638 no 2298 0.3269375521144 3308 825140
SGTC_338 4055-0136 114 µM -0.450309987497487 0.32316944051313 no 2299 0.326243469233343 3174 2900563
SGTC_939 1165-0479 45.3 µM -0.451132503851231 0.322876109256065 no 2300 0.325947026223865 3306 1377347
SGTC_1527 coumarin 137 µM -0.454640048640161 0.321626463548546 no 2301 0.324684108911372 3341 323 A hepatotoxic, DNA x-linker.
SGTC_583 1488-1091 88.9 µM -0.456033578045649 0.321130544404249 no 2302 0.324182916268215 3304 4303273
SGTC_2137 5261020 140 µM -0.457339118540367 0.320666227340858 no 2303 0.323713658323288 3196 763655
SGTC_2110 5483698 200 µM -0.458151683981121 0.32037737899749 no 2304 0.323421734621673 3224 2848765 YHR062C RPP1
SGTC_1126 isoteolin 1.0172 µM -0.459963623983879 0.319733667902834 no 2305 0.322771165358582 3192 133323
SGTC_1382 3002-2117 298 µM -0.460469722215024 0.319553967943857 no 2306 0.322589549725371 3361 1497314
SGTC_489 paxilline 115 µM -0.462239086306207 0.318926054181432 no 2307 0.321954938281971 3271 105008 A toxic potassium channel blocker.
SGTC_1973 st070275 50.2 µM -0.463054828713387 0.318636737466188 no 2308 0.321662533533025 3277 17118334
SGTC_1181 1222-0449 220 µM -0.463360488507621 0.318528358554595 no 2309 0.321552997507415 3361 658318
SGTC_2162 5663267 200 µM -0.463561202128762 0.318457199235564 no 2310 0.32148107835467 3352 6456493
SGTC_5 0352-0601 109.883 µM -0.464238817291927 0.318217012734007 no 2311 0.321238326593283 3256 762456
SGTC_2734 clemastine 41.6 µM -0.464276083100825 0.318203805764539 no 2312 0.321224978544288 3246 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_662 k832-1615 104 µM -0.466659629999948 0.317359559610214 no 2313 0.320371708508153 3294 5878478
SGTC_122 0236-0016 402.397 µM -0.467154646257948 0.317184345037825 no 2314 0.320194619774422 3269 6808838
SGTC_1166 k206-0078 225 µM -0.468320987435337 0.316771672222126 no 2315 0.319777531028574 3253 5404595
SGTC_1391 3442-0225 151 µM -0.469271948598485 0.316435373413292 no 2316 0.319437631660691 3191 5227075
SGTC_2369 9071472 200 µM -0.470366319912518 0.316048546681792 no 2317 0.319046661299949 3323 17296037
SGTC_792 4534-1957 155 µM -0.47162306152909 0.315604575338573 no 2318 0.318597931444661 3224 1717904
SGTC_1383 3049-0032 20.7 µM -0.472738617626922 0.315210703670263 no 2319 0.318199835773625 3353 712864
SGTC_997 3996-0078 137 µM -0.473422700001763 0.314969277130414 no 2320 0.317955818958293 3263 735687
SGTC_2357 9067248 200 µM -0.474110803398717 0.314726511221256 no 2321 0.317710447529871 3318 9150235
SGTC_205 1486-1330 71.903 µM -0.474782085062025 0.314489757233036 no 2322 0.31747115170359 3269 4118834
SGTC_2075 5212009 200 µM -0.476377170455271 0.313927493444433 no 2323 0.316902848011242 3336 780898
SGTC_2081 5214970 32.255 µM -0.476521494170364 0.313876640960746 no 2324 0.316851449033652 3315 2063512
SGTC_3164 9100705 49.47 µM -0.478278760694495 0.313257751616097 no 2325 0.316225905643635 3377 17174235
SGTC_3002 9075603 71.4286 µM -0.478686032565134 0.313114390038889 no 2326 0.31608100189655 3334 20105405
SGTC_883 0850-0245 24.6 µM -0.478878031098072 0.313046815464932 no 2327 0.316012700304248 3396 6823229 YPR165W RHO1
SGTC_425 3825-7017 13.1 µM -0.479177063149836 0.312941582565448 no 2328 0.315906335096067 3406 3397440
SGTC_1448 4255-0083 152 µM -0.47966927212975 0.312768401618608 no 2329 0.315731290363764 3372 5399660
SGTC_3141 9094609 49.47 µM -0.480629177716442 0.312430783154534 no 2330 0.31539003716143 3155 25236309 YDL196W YDL196W
SGTC_2584 androsterone 48.74 µM -0.482004144652182 0.311947453331824 no 2331 0.314901500994629 3338 2754130 A steroid.
SGTC_666 0272-0154 136 µM -0.482150674462164 0.311895964086726 no 2332 0.314849456915213 3287 6870312
SGTC_1975 st070967 30.8 µM -0.482298756605327 0.311843933100298 no 2333 0.3147968652175 3397 261391
SGTC_107 0358-0022 2.6945 µM -0.48418406314963 0.311181829559626 no 2334 0.314127623080872 3303 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_353 1988-1175 58.3 µM -0.486002846013075 0.310543667029361 no 2335 0.313482574049484 3175 2788357
SGTC_1884 5633444 25 µM -0.486011100254801 0.310540772132838 no 2336 0.313479647900277 3363 5724239
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.48605742620354 0.31052452508856 no 2337 0.313463225454136 3256 4330530
SGTC_347 4534-1311 26.2 µM -0.487063392141523 0.310171812437618 no 2338 0.313106704002852 3307 2862016
SGTC_2474 5321570 43.32 µM -0.487991942261374 0.309846398301772 no 2339 0.312777774258493 3323 2841384
SGTC_1349 flufenamic acid 69 µM -0.488014672479877 0.309838434271597 no 2340 0.312769724169845 3267 3371 A non-steroidal anti-inflammatory.
SGTC_2644 guaiazulene 100 µM -0.490891406523042 0.308831228884849 no 2341 0.311751627673738 3338 3515 A coloring agent.
SGTC_2551 apiole 73.87 µM -0.491296043021378 0.308689672125664 no 2342 0.311608539066777 3257 10659 A possible DNA adduct former.
SGTC_2861 9024595 19.48 µM -0.491457333188653 0.308633254802616 no 2343 0.311551511147191 3262 16482810
SGTC_1097 itavastatin 7.23 µM -0.491595814807767 0.308584819233985 no 2344 0.311502551331067 3308 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1407 3909-7909 12.3 µM -0.491732954669839 0.308536856242776 no 2345 0.311454069174293 3319 4411780
SGTC_1453 4237-0541 195 µM -0.492004805675517 0.308441789332096 no 2346 0.311357973134126 3358 739892
SGTC_1492 4158-0558 28.5 µM -0.492154123512927 0.308389578010871 no 2347 0.311305196553826 3342 3967268
SGTC_1800 st050079 29.0735 µM -0.492243258343817 0.308358412467838 no 2348 0.311273693582537 3323 3645560
SGTC_1605 st000082 49.1 µM -0.492987421769143 0.308098273403567 no 2349 0.31101073746071 3359 1114022
SGTC_1199 1638-0010 4.46 µM -0.493311312463016 0.307985080220454 no 2350 0.310896318202174 3241 3111136
SGTC_3143 9086658 49.47 µM -0.494289706537045 0.30764326242866 no 2351 0.310550796832547 3319 25236626
SGTC_1190 1486-1332 13 µM -0.495222066074652 0.307317682856841 no 2352 0.310221688078294 3331 4150046
SGTC_2987 9018338 71.43 µM -0.497729319697615 0.306442904373756 no 2353 0.309337419824098 3415 5055682
SGTC_1873 rapamycin 2 nM -0.497741132675499 0.306438785440912 no 2354 0.309333256182661 3304 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1440 4100-1550 40 µM -0.498893133178162 0.306037225037798 no 2355 0.308927335929168 3325 742806
SGTC_2103 5378138 10 µM -0.499713988033714 0.305751236370737 no 2356 0.308638240821313 3407 244142
SGTC_3306 9127676 59.7925 µM -0.500809022809385 0.305369906858125 no 2357 0.308252767477801 3333 41905287
SGTC_1429 4049-0205 9.46 µM -0.501270004801627 0.305209439875411 no 2358 0.308090556123219 3369 22774478
SGTC_440 fluspirilene 35.1 µM -0.501348550722747 0.305182101916595 no 2359 0.308062920948523 3449 3396 An atypical antipsychotic.
SGTC_1914 st062367 72.6 µM -0.501410568784327 0.305160517257887 no 2360 0.308041101615917 3259 978205
SGTC_2180 6301957 200 µM -0.501896768563175 0.304991324614366 no 2361 0.307870069241133 3360 845462
SGTC_2687 chenodiol 100 µM -0.50240603040148 0.304814151295819 no 2362 0.307690968983761 3375 5702181 A cholesterol synthesis inhibitor.
SGTC_1556 plumbagin 1.48 µM -0.505793752188788 0.303636721660129 no 2363 0.30650072249838 3348 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2616 abietic acid 100 µM -0.506051815517079 0.303547112978178 no 2364 0.306410137597119 3417 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_249 wiskostatin 11.211 µM -0.50611624754782 0.303524741748973 no 2365 0.306387522632817 3389 2775510 A n-wasp and actin depolymerizer.
SGTC_1561 5-methoxyflavone 52.9 µM -0.506291184144337 0.303464006314196 no 2366 0.306326125449024 3354 94525
SGTC_1346 1488-2224 62.4 µM -0.506604220867349 0.303355338081378 no 2367 0.306216273083179 3391 3722427
SGTC_878 0828-0289 13.7 µM -0.509089557487888 0.302493190923775 no 2368 0.305344725524338 3318 745350 YLR208W SEC13
SGTC_1253 0550-0034 176 µM -0.509986878170096 0.302182186326475 no 2369 0.305030327383347 3379 5969915
SGTC_942 3253-1115 227 µM -0.510664572683746 0.301947397679079 no 2370 0.304792975947092 3439 46497897
SGTC_2718 lomofungin 53.02 µM -0.510742283967855 0.301920479684408 no 2371 0.304765764086097 3410 5351222 A RNA synthesis inhibitor.
SGTC_1411 3909-8223 150 µM -0.511012742852907 0.301826805289356 no 2372 0.304671066961324 3384 X1411
SGTC_2533 agelasine 13.65 µM -0.511471054807263 0.301668097146614 no 2373 0.304510625781256 3475 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1306 1185-0270 9.02 µM -0.512206092342622 0.301413640519359 no 2374 0.304253389857798 3382 1548076
SGTC_507 nimesulide 162 µM -0.512477953420739 0.301319551638841 no 2375 0.3041582730698 3454 4495 A COX2 inhibitor.
SGTC_3259 9138485 49.47 µM -0.513341342782448 0.301020827423641 no 2376 0.303856284535125 3553 17646153
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.513840790445612 0.300848084423294 no 2377 0.303681653324676 3310 5106787 A p450 inhibitor.
SGTC_691 1548-0686 185 µM -0.514307672088015 0.300686645417497 no 2378 0.30351844930287 3317 46495133
SGTC_1155 4088-0394 48.2 µM -0.515789626525403 0.300174472297117 no 2379 0.303000674240528 3280 2326248
SGTC_1710 st031758 61.5 µM -0.516371133422885 0.29997360754247 no 2380 0.302797611538043 3447 5394341
SGTC_1369 1866-0067 208 µM -0.517535581939217 0.299571565408892 no 2381 0.302391168449432 3429 3531355
SGTC_1473 k844-0725 134 µM -0.518410504914659 0.299269646779813 no 2382 0.302085943433725 3428 54682906
SGTC_720 r052-1644 49.9 µM -0.518919645093638 0.299094016130232 no 2383 0.301908388844197 3386 1422863 YOR257W CDC31
SGTC_1491 4138-0063 26.5 µM -0.519035195546622 0.299054162894155 no 2384 0.301868098979461 3367 23883227
SGTC_1418 3966-3099 2.4 µM -0.523244651459412 0.297603972702262 no 2385 0.300402006152224 3410 740335
SGTC_2673 kobusone 100 µM -0.523584736113317 0.297486951163714 no 2386 0.300283700143595 3417 6710676 An epoxy ketone and protein crosslinker.
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.525134208066925 0.296954051253853 no 2387 0.299744948634209 3396 17037758
SGTC_1702 st027038 51 µM -0.525885749053901 0.296695735982992 no 2388 0.29948379553329 3377 5521182
SGTC_1432 4049-0298 68.4 µM -0.526885574135785 0.296352241549897 no 2389 0.299136526132498 3403 741646
SGTC_2274 7947094 46.08 µM -0.527103117086463 0.29627752784241 no 2390 0.299060991123008 3420 2971028
SGTC_1353 1498-1206 8.11 µM -0.530125550515649 0.295240387758784 no 2391 0.298012442531878 3454 6756808
SGTC_3355 9151058 44.0485 µM -0.532158704866947 0.294543657761704 no 2392 0.297308040615705 3417 17015728
SGTC_2346 9031566 143.75 µM -0.534919223235359 0.293598887888923 no 2393 0.296352857484711 3334 4771086
SGTC_2282 7944268 200 µM -0.535185387190952 0.293507869175357 no 2394 0.296260834951493 3481 2970414
SGTC_81 0411-0046 9.971 µM -0.535194364672251 0.293504799420267 no 2395 0.296257731339075 3360 12925265
SGTC_2010 4012422 159 µM -0.535460462301956 0.293413816894069 no 2396 0.296165745281701 3343 952393
SGTC_2327 6189656 200 µM -0.537315584926412 0.292779887732979 no 2397 0.295524820960434 3410 5349088
SGTC_3237 9133362 49.47 µM -0.539718690821011 0.291959649495784 no 2398 0.2946955240512 3410 43845137
SGTC_1172 0370-0043 85 µM -0.539890423820439 0.291901073853474 no 2399 0.294636301172742 3447 376585
SGTC_2132 5317594 122.667 µM -0.54360151188869 0.290636614657936 no 2400 0.293357859583195 3344 794577
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.544313680431004 0.290394254626276 no 2401 0.293112817217001 3443 688798
SGTC_270 tamoxifen 5.46 µM -0.548433626276775 0.288994045066653 no 2402 0.291697096269066 3540 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_539 4859-0462 2.54 µM -0.550337562046601 0.288348046095172 no 2403 0.291043932706708 3448 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1394 3474-0001 65.7 µM -0.552207670362652 0.287714188248623 no 2404 0.290403039878754 3367 5017666 YIL048W NEO1
SGTC_546 peri-Naphthalide 147 µM -0.552724642138672 0.287539081142494 no 2405 0.290225988438485 3346 223824 A penicillin ester.
SGTC_2567 aureobasidin a 60 nM -0.552892359812715 0.287482283149444 no 2406 0.290168559697002 3498 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_71 0417-1750 47.813 µM -0.553050076444261 0.287428876874293 no 2407 0.290114560302496 3464 6811472
SGTC_765 1319-0117 244 µM -0.554343010869553 0.286991238223366 no 2408 0.289672059999321 3438 3487746 YGL099W LSG1
SGTC_708 3448-5400 146 µM -0.554977899376721 0.286776453723485 no 2409 0.289454888632847 3441 3462195
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.555356441796373 0.286648428068175 no 2410 0.289325439978799 3386 15053
SGTC_2889 9059656 51.95 µM -0.555615663211111 0.286560773237285 no 2411 0.289236810752846 3447 3949838
SGTC_3034 9090421 49.47 µM -0.556017431015183 0.286424941965312 no 2412 0.289099469357209 3416 17173761
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.557041905103254 0.286078722017425 no 2413 0.28874939923766 3427 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_963 1269-2853 151 µM -0.557120660894177 0.286052114812801 no 2414 0.288722496084456 3380 3668223
SGTC_2879 9041815 71.43 µM -0.55787196902084 0.285798348688056 no 2415 0.288465906916872 3412 4942971
SGTC_948 3448-0295 75.3 µM -0.558779632280386 0.285491914042209 no 2416 0.288156062266631 3473 678569
SGTC_901 1112-0062 60.1 µM -0.558861698454102 0.285464215533678 no 2417 0.288128055472817 3422 1908457
SGTC_467 ro 31-8220 72.8 µM -0.559134499835036 0.285372150359009 no 2418 0.288034965542808 3362 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_88 0180-0332 8.668 µM -0.559255395904911 0.285331354802988 no 2419 0.287993715868327 3423 3101745
SGTC_1135 dihydrocapsaicin 536.708 nM -0.559742289091061 0.285167084139696 no 2420 0.287827616410684 3421 107982 A Capsaicinoid.
SGTC_2693 st077581 40.7 µM -0.56129243524995 0.284644387828245 no 2421 0.28729909884427 3464 25238761
SGTC_634 1611-4317 11.2 µM -0.563958591466559 0.283746453678703 no 2422 0.286391156730579 3493 2843522
SGTC_1426 4048-4480 71.7 µM -0.565499796643957 0.28322801096103 no 2423 0.285866931280437 3478 14224343
SGTC_1227 3909-8010 46.6 µM -0.567060995330194 0.282703306383676 no 2424 0.285336370858293 3399 15982272
SGTC_1680 diphenhydramine 100 µM -0.569148104329861 0.282002578636124 no 2425 0.284627817698532 3400 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_43 0570-0105 72.5 µM -0.569336948228986 0.281939217317708 no 2426 0.284563748502829 3488 1114046 YDL195W SEC31
SGTC_2962 9082311 13.18 µM -0.570136509508884 0.281671022782768 no 2427 0.284292557154041 3385 16459453
SGTC_1248 0469-0687 58.6 µM -0.571207701712131 0.281311908775332 no 2428 0.283929429068658 3444 4017482
SGTC_2252 omeprazole 400 µM -0.572920326217543 0.280738216065229 no 2429 0.28334932063658 3405 4594 A proton pump inhibitor.
SGTC_1866 st057638 64 µM -0.574592625527813 0.28017857800909 no 2430 0.282783420326115 3423 688802
SGTC_380 3970-0968 6 µM -0.576489391903058 0.279544476599591 no 2431 0.282142219026432 3424 2891601
SGTC_3256 9138902 49.47 µM -0.576509236969381 0.279537845948935 no 2432 0.282135514109248 3460 17228773
SGTC_1354 1498-1681 81 µM -0.577735683160951 0.279128212946831 no 2433 0.281721292031681 3485 5754243
SGTC_2560 caryophyllene 100 µM -0.578257113091139 0.278954143819056 no 2434 0.281545272239465 3446 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2185 6113692 200 µM -0.578291098567351 0.278942800269461 no 2435 0.281533801558952 3483 874150
SGTC_1516 st013856 110 µM -0.579352350751001 0.278588692300596 no 2436 0.281175724240517 3462 5281404 A mutagen and neurotoxin.
SGTC_1384 3089-0840 101 µM -0.581034937531971 0.278027712762298 no 2437 0.280608453495065 3477 1069836
SGTC_590 k048-0076 22.4 µM -0.581239776256528 0.27795945656116 no 2438 0.280539431576681 3493 6832814
SGTC_2838 9002687 71.43 µM -0.582540996237783 0.277526056119391 no 2439 0.280101167887276 3428 6457060
SGTC_212 3807-4682 38.772 µM -0.582857229185305 0.27742077756142 no 2440 0.279994707660939 3511 3125501 YBL034C STU1
SGTC_2670 beta-carotene 100 µM -0.583132907263453 0.277329016242067 no 2441 0.279901916290792 3466 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_849 0386-0493 241 µM -0.583287040269949 0.2772777184945 no 2442 0.279850042667586 3404 726119
SGTC_2136 5328288 199.296 µM -0.585840382528324 0.276428604235685 no 2443 0.27899139180661 3420 262395
SGTC_1175 0741-0056 27.6 µM -0.586065652566882 0.276353751919124 no 2444 0.278915698415725 3557 765927
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.58659888105815 0.276176611362109 no 2445 0.27873656717657 3415 390807
SGTC_3301 9125354 19.7965 µM -0.587434069524661 0.27589927059167 no 2446 0.278456108979334 3487 41905162
SGTC_1232 0279-0259 161 µM -0.588298002216606 0.27561252877158 no 2447 0.278166143154306 3475 1560000
SGTC_1875 nocodazole 6 µM -0.589058206540203 0.275360335960413 no 2448 0.27791111403302 3535 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.590638751232117 0.274836364354622 no 2449 0.27738124726533 3431 6857784
SGTC_639 0833-0042 114 µM -0.591182979529114 0.274656059241509 no 2450 0.277198912848565 3459 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1044 1222-0021 1.78 µM -0.591188844301666 0.27465411653558 no 2451 0.277196948275845 3462 4306703
SGTC_742 0kpi-0133 140 µM -0.591682561259909 0.274490597094879 no 2452 0.277031588136361 3511 2728852
SGTC_1366 1683-0113 21.9 µM -0.592186534199369 0.274323730426444 no 2453 0.276862842785216 3482 708623
SGTC_1852 st056254 31.4 µM -0.593445033793793 0.273907256950717 no 2454 0.276441679066174 3426 442583
SGTC_897 1000-0139 31.4 µM -0.594557116384125 0.273539497371464 no 2455 0.276069776262838 3520 6151020
SGTC_2342 7990637 118.86 µM -0.595137418474702 0.273347691750492 no 2456 0.27587580914758 3512 2033102 YER133W GLC7
SGTC_3327 9140648 26.9345 µM -0.596161287009054 0.273009437869476 no 2457 0.275533742437814 3517 8029710
SGTC_89 0302-0250 142.109 µM -0.596177804472153 0.273003982721735 no 2458 0.275528225788906 3567 4203518 YLR208W SEC13
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.596791379868218 0.272801378250553 no 2459 0.275323336931338 3499 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_850 0388-0143 75.9 µM -0.597962779520571 0.272414785755094 no 2460 0.274932384325781 3459 67273
SGTC_3074 9116018 49.47 µM -0.600912188848661 0.271442610271804 no 2461 0.273949237191887 3511 17027303
SGTC_834 0312-0008 75.7 µM -0.601997805346129 0.271085208292211 no 2462 0.273587799132451 3524 6385573 YIL048W NEO1
SGTC_757 1066-0008 322 µM -0.602063911949968 0.271063452544501 no 2463 0.27356579765654 3525 6842497
SGTC_804 1595-0054 20.9 µM -0.602642712247667 0.2708730060027 no 2464 0.273373199830725 3460 761523 Stimulates phospholipase C.
SGTC_3234 9132280 49.47 µM -0.60268463792366 0.270859213510657 no 2465 0.273359251523632 3536 17612295
SGTC_1471 k673-0312 37 µM -0.602940322073231 0.270775107449059 no 2466 0.27327419526413 3509 24099884
SGTC_922 1866-0035 480 µM -0.604032649627817 0.27041593848738 no 2467 0.272910967700238 3511 3156169
SGTC_1159 4092-0538 61.2 µM -0.604888186760351 0.270134795114605 no 2468 0.272626646454537 3557 717301
SGTC_2641 levomentholum 100 µM -0.60607842283575 0.269743907591642 no 2469 0.272231339184101 3491 16666
SGTC_2485 5633444 17.78 µM -0.609769486773208 0.268533522906833 no 2470 0.271007258515132 3508 5724239
SGTC_994 3910-0338 138 µM -0.610528290983188 0.268285032314368 no 2471 0.270755954253013 3585 3479481
SGTC_3222 9128301 49.47 µM -0.610714343942996 0.268224121994258 no 2472 0.270694354144473 3501 4911358
SGTC_395 anisomycin 6.25 µM -0.61078215417898 0.268201923899326 no 2473 0.27067190465414 3496 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3067 9117431 49.47 µM -0.611613674386451 0.267929795870388 no 2474 0.27039669433443 3490 17150885
SGTC_2508 celastrol 40.54 µM -0.612053749178247 0.26778583078336 no 2475 0.270251098298428 3499 122724 Celastrol is a natural product and antioxidant.
SGTC_2089 5281248 129.67 µM -0.613400350929918 0.267345548711239 no 2476 0.269805827034818 3553 2737878
SGTC_3287 9117173 37.0625 µM -0.613871474307281 0.267191597485956 no 2477 0.269650130791351 3485 2789709
SGTC_2218 6965428 192.983 µM -0.615672014656178 0.266603638946921 no 2478 0.269055505570285 3526 675684
SGTC_2513 baicalein 25.65 µM -0.616250612107281 0.26641483947748 no 2479 0.268864564609276 3496 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3060 1327-0027 12.5 µM -0.618217055910528 0.265773684271734 no 2480 0.268216134270777 3479 16000455 YPR107C YTH1
SGTC_320 4092-0846 5.34 µM -0.621424453267103 0.264729599520205 no 2481 0.26716019345838 3502 1359356
SGTC_981 1488-1094 54.9 µM -0.622367682596543 0.264422953106942 no 2482 0.266850062849157 3538 3449522
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.626009875808 0.263240565482286 no 2483 0.265654231845573 3577 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1251 0490-5699 265 µM -0.62762160752543 0.262718202347595 no 2484 0.265125925193846 3609 3883818
SGTC_2228 7354201 200 µM -0.627786220653275 0.262664881002846 no 2485 0.265071997000687 3585 753451
SGTC_2804 7954240 19.48 µM -0.628508705153219 0.262430919936446 no 2486 0.264835372901536 3566 828705
SGTC_3018 9082602 49.47 µM -0.629908714906864 0.261977860786167 no 2487 0.264377155338614 3563 17332089
SGTC_3285 9112818 20.8695 µM -0.630918482415934 0.261651337581576 no 2488 0.264046913185458 3601 17017947 YPR165W RHO1
SGTC_753 1322-0200 289 µM -0.631857499913755 0.261347879959448 no 2489 0.263739998392845 3612 5403907
SGTC_2855 9016525 58.44 µM -0.632131263147888 0.261259443300926 no 2490 0.263650554043255 3583 43811474
SGTC_1294 1000-1494 117 µM -0.633155646386621 0.260928662311242 no 2491 0.263316003301533 3543 712797 YDL207W GLE1
SGTC_315 k915-0449 187 µM -0.63344505131044 0.260835250337398 no 2492 0.263221526565304 3569 20970215 YNL149C PGA2
SGTC_1185 1319-0113 81.3 µM -0.634063275742305 0.26063576208396 no 2493 0.263019764151222 3575 4672763
SGTC_625 k213-0058 121 µM -0.635827843008892 0.260066804948593 no 2494 0.26244431882453 3623 3655420
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.636894771034458 0.259723101593573 no 2495 0.262096694497686 3575 2724 A muscle relaxant with antifungal properties.
SGTC_3078 9116413 49.47 µM -0.63691914391611 0.25971525278102 no 2496 0.262088756132667 3527 17177322
SGTC_2149 5554786 194.827 µM -0.63741272680867 0.259556330355523 no 2497 0.261928020326822 3575 745063 YPR165W RHO1
SGTC_1111 tnp00062 510.699 nM -0.639175054677059 0.258989310995498 no 2498 0.261354529058492 3607 676306
SGTC_527 4476-4215 268 µM -0.640495224324962 0.258564973733655 no 2499 0.260925346467032 3525 4418754
SGTC_969 1313-0238 134 µM -0.641657817324894 0.258191584111754 no 2500 0.260547691869383 3582 5212874
SGTC_2379 9035213 200 µM -0.641684396816332 0.258183050854562 no 2501 0.260539061127372 3607 646551
SGTC_2038 4100038 30.985 µM -0.641890353563479 0.258116934083074 no 2502 0.260472189007984 3575 3596803
SGTC_3052 9092717 49.47 µM -0.642556143381691 0.257903260579995 no 2503 0.260256074123702 3571 25237534
SGTC_1892 st058411 7.36 µM -0.644535165331968 0.257268670633375 no 2504 0.259614231009316 3562 3934738
SGTC_1031 k035-0009 16 µM -0.644808103187282 0.257181214557912 no 2505 0.259525775045866 3611 5180959
SGTC_2152 5568786 200 µM -0.644896561158239 0.257152873741516 no 2506 0.259497110192922 3571 5399883
SGTC_544 k015-0020 52.4 µM -0.646293878129947 0.256705406561206 no 2507 0.259044525888627 3578 3008304
SGTC_3211 9128781 49.47 µM -0.646805625258376 0.256541629658532 no 2508 0.258878875614602 3542 17194361
SGTC_2424 5537928 59.2 µM -0.649438998033403 0.255699720099412 no 2509 0.258027331964546 3616 5382802
SGTC_854 0422-0053 192 µM -0.651846881975114 0.25493116562408 no 2510 0.257249977208156 3605 3596728
SGTC_6 0844-0013 19.835 µM -0.651967068332611 0.254892835938635 no 2511 0.2572112084922 3688 1584900
SGTC_3297 9117502 71.43 µM -0.652495900948512 0.254724217130148 no 2512 0.25704065815755 3590 7453720
SGTC_1180 1193-0155 285 µM -0.652554424581542 0.254705560401327 no 2513 0.257021787700524 3597 2921347
SGTC_257 daunorubicin 18.5 µM -0.653010417231554 0.254560219172351 no 2514 0.256874781361525 3635 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_556 4058-0063 51.5 µM -0.653038524874007 0.254551261679327 no 2515 0.256865721240306 3656 6615692
SGTC_1896 st058441 89 µM -0.653952657042594 0.254260031211796 no 2516 0.256571153684379 3548 688759
SGTC_920 mycophenolic acid 780.421 nM -0.656395796782327 0.253482537275787 no 2517 0.255784747084972 3594 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2041 5107442 45.335 µM -0.65677704346049 0.253361323809134 no 2518 0.255662143628686 3625 793005
SGTC_132 0417-1715 25.805 µM -0.657463231874678 0.253143234041729 no 2519 0.255441552638373 3648 6769098
SGTC_569 4130-2812 160 µM -0.658379898989479 0.252852045859985 no 2520 0.255147024234957 3525 743552
SGTC_321 4534-3890 65.3 µM -0.658426311943265 0.252837307027099 no 2521 0.255132116313117 3616 699746
SGTC_473 2-arachidonoylglycerol 10 µM -0.658923200968068 0.252679543984672 no 2522 0.254972543240219 3537 5282280 An endocannabinoid.
SGTC_730 1436-0052 41.2 µM -0.66029349998587 0.252244740676131 no 2523 0.254532750271402 3626 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3163 9099914 49.47 µM -0.660780115745712 0.25209042983901 no 2524 0.254376668219695 3631 16268368
SGTC_2495 cafestol 54.53 µM -0.661106888615299 0.25198683477368 no 2525 0.254271883951403 3625 16667697 An anti-infammatory.
SGTC_1161 k007-0610 110 µM -0.66242400762578 0.251569503401479 no 2526 0.253849760954049 3658 5843850
SGTC_3319 9138450 16.7555 µM -0.662821950195166 0.251443486495074 no 2527 0.253722296879856 3574 2029690
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.664653656713133 0.250863868459068 no 2528 0.253136020810063 3598 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2963 9082507 9 µM -0.664682446621917 0.250854763942153 no 2529 0.253126811687335 3628 16459611
SGTC_2978 9011784 42.97 µM -0.666014146383872 0.250433818629012 no 2530 0.252701029180083 3681 2994934
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.667029182500975 0.250113221106445 no 2531 0.252376746581802 3643 23847180
SGTC_472 calcifediol 10 µM -0.667748477544071 0.249886164798934 no 2532 0.252147079875441 3610 5283731 A vitamin D metabolite.
SGTC_1509 1326-1131 80 µM -0.66952386894986 0.249326204413142 no 2533 0.251580679947025 3578 768313
SGTC_2102 5377816 72.7585 µM -0.671371786673819 0.248744078422628 no 2534 0.250991856744499 3649 1379702
SGTC_2399 5884133 200 µM -0.671443598253909 0.248721471152888 no 2535 0.250968989327302 3639 722445
SGTC_3235 9132602 49.47 µM -0.671637738532961 0.248660358609822 no 2536 0.250907173525959 3657 4912240
SGTC_1438 4092-1045 4 µM -0.67191771517807 0.248572240109336 no 2537 0.250818040939451 3619 1351342
SGTC_1133 3473-0247 50 µM -0.67238294875624 0.248425851531295 no 2538 0.250669967549992 3602 711311
SGTC_567 1080-0542 68.4 µM -0.674203692652756 0.247853385433448 no 2539 0.250090911154517 3577 5950415
SGTC_2759 disulfiram 3.38 µM -0.674225983517573 0.247846381255015 no 2540 0.250083826326575 3601 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3148 9097893 49.47 µM -0.6744871329762 0.247764331411784 no 2541 0.250000831691898 3571 17174100
SGTC_3112 9123419 49.47 µM -0.674490759476595 0.247763192113524 no 2542 0.249999679274407 3675 17015854
SGTC_12 0849-0099 9.267 µM -0.674667494939693 0.247707672441786 no 2543 0.249943520270521 3580 6071388
SGTC_2765 myclobutanil 7.74 µM -0.674699100620181 0.247697744534834 no 2544 0.249933478036944 3654 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_291 SEC14.278 35.5 µM -0.675365509467156 0.247488463135385 no 2545 0.249721786433076 3633 1068044
SGTC_2384 9036245 200 µM -0.676287792341498 0.247198982084649 no 2546 0.249428970968124 3636 6462766
SGTC_349 k015-0014 24 µM -0.676722892604592 0.247062478106366 no 2547 0.249290894421409 3623 2196908
SGTC_2411 st077133 39.94 µM -0.677290256189039 0.246884539756823 no 2548 0.249110905941331 3732 1403142 YNL221C POP1
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.678013429213559 0.24665783543135 no 2549 0.248881589256075 3656 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_786 4544-0069 423 µM -0.678916514870125 0.246374887706023 no 2550 0.248595380489956 3654 748821 YLR208W SEC13
SGTC_2080 5212524 12.4 µM -0.680152222386103 0.245988007555382 no 2551 0.248204040420069 3620 260183
SGTC_1749 st037932 54.2 µM -0.682272081724908 0.245325073640831 no 2552 0.247533461509973 3640 594497
SGTC_3036 9090181 49.47 µM -0.68334672645994 0.244989372080272 no 2553 0.247193887300793 3661 25236586
SGTC_2883 9059145 45.46 µM -0.683572151566664 0.244918984310504 no 2554 0.247122687426982 3644 16476510
SGTC_959 1222-0044 107 µM -0.683677803252297 0.244885998889069 no 2555 0.24708932142054 3629 6083612
SGTC_3069 9117009 49.47 µM -0.683826551981266 0.244839562229764 no 2556 0.247042348961798 3536 41904981
SGTC_17 0960-0276 49.807 µM -0.683829960219256 0.244838498295131 no 2557 0.247041272750986 3656 6821114
SGTC_1228 0124-0032 52.5 µM -0.683930259213284 0.24480718951433 no 2558 0.247009602710794 3691 X1228
SGTC_450 aminopyrene 156 nM -0.688239204615756 0.243464170158359 no 2559 0.245651079662653 3611 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_418 lividomycin a 100 µM -0.688639457139658 0.24333962113309 no 2560 0.245525092153944 3667 72394 An antibiotic.
SGTC_575 k072-0246 11.9 µM -0.688707171624553 0.243318553408755 no 2561 0.245503781095499 3672 6796779
SGTC_1245 0418-0076 17.2 µM -0.688708823157519 0.243318039586529 no 2562 0.245503261338537 3655 6790114
SGTC_1976 st070609 63.5 µM -0.689253692758319 0.243148552666034 no 2563 0.245331816705537 3605 682556
SGTC_175 3793-3120 23.7 µM -0.689422560995278 0.243096037540226 no 2564 0.245278694942864 3660 5322297
SGTC_2206 7254556 146.969 µM -0.689751595033228 0.242993731218063 no 2565 0.245175206752899 3654 4398905
SGTC_2843 9000894 45.46 µM -0.689926184917577 0.242939455567026 no 2566 0.245120304064044 3534 2242070
SGTC_3265 9137266 49.47 µM -0.691305246286011 0.242510970298775 no 2567 0.244686867794809 3606 17224265
SGTC_2036 5160441 105 µM -0.69181137061026 0.242353816212603 no 2568 0.24452789750099 3677 134534 YIL048W NEO1
SGTC_2167 5876490 200 µM -0.692495501553772 0.242141477935676 no 2569 0.244313104966955 3742 686534
SGTC_2541 muurolladie-3-one 83.07 µM -0.692657368615497 0.242091252937499 no 2570 0.244262299406888 3691 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_894 0960-0238 55.9 µM -0.694255085090571 0.24159580791282 no 2571 0.243761126418333 3638 6741907 YDL195W SEC31
SGTC_1088 bifonazole 369 nM -0.696167635933108 0.241003458776838 no 2572 0.243161926605503 3614 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2642 cholecalciferol 100 µM -0.696235035702348 0.240982598352673 no 2573 0.243140824877967 3655 9821465 A vitamin D precursor, similar to steriods.
SGTC_845 0330-0138 4.51 µM -0.696493132466678 0.240902725735932 no 2574 0.243060028303719 3636 9039800
SGTC_1672 st016598 6.51 µM -0.697242184194595 0.240670999973109 no 2575 0.242825621699587 3677 4665860 YNL267W PIK1
SGTC_2004 4023728 41.89 µM -0.698204456322903 0.240373490728134 no 2576 0.242524669989732 3656 360084 YDR527W RBA50
SGTC_828 2074-0507 139 µM -0.698610287632045 0.240248078444565 no 2577 0.242397806374552 3714 X828
SGTC_1987 st072290 61.9 µM -0.69916468343916 0.240076813559679 no 2578 0.242224559346045 3678 54697379
SGTC_1296 1068-0102 11.9 µM -0.699640833563927 0.239929773609818 no 2579 0.242075817452563 3669 767053
SGTC_2366 9070441 60.58 µM -0.700651371163509 0.239617872228778 no 2580 0.241760305392081 3678 6837235
SGTC_1539 benzyladenosine 56 µM -0.700834826479591 0.239561272681341 no 2581 0.241703050553844 3664 92208 A nucleotide analog.
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.701985416048297 0.239206459816801 no 2582 0.241344129263286 3768 5282309
SGTC_2025 5147754 141 µM -0.702105639090145 0.239169402633363 no 2583 0.241306642938101 3689 315777 YLR208W SEC13
SGTC_3295 9122362 53.5725 µM -0.70310265346497 0.238862206888768 no 2584 0.240995889330215 3683 4730473
SGTC_1660 st012960 28.1 µM -0.705003220694595 0.23827721060932 no 2585 0.240404115934382 3666 24207266
SGTC_1337 1486-1011 40.3 µM -0.705292033372844 0.238188382552593 no 2586 0.240314258605048 3690 X1337
SGTC_2656 pseudo-anisatin 100 µM -0.707786340045834 0.237421981924493 no 2587 0.239538975229194 3721 6708809 A neurotoxin.
SGTC_2638 epoxomicin 18 µM -0.708465539569542 0.237213525852682 no 2588 0.239328102406093 3698 9915668 A protesome inhibitor.
SGTC_3152 9099253 49.47 µM -0.70850032515094 0.237202852366072 no 2589 0.23931730516759 3678 25236131
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.709285535509681 0.236961991357806 no 2590 0.239073651331 3667 77254
SGTC_13 0199-0087 65 µM -0.709305515304022 0.236955864368031 no 2591 0.239067453292472 3720 4589825
SGTC_2917 7979103 53.79 µM -0.709608630794207 0.236862921866378 no 2592 0.238973432995494 3708 2980565
SGTC_1231 0242-0792 125 µM -0.710132798300965 0.23670224680847 no 2593 0.238810894552176 3685 3707635
SGTC_1631 benzylvanillin 81.9 µM -0.71100660568226 0.23643452863576 no 2594 0.238540071201942 3710 75506
SGTC_718 1130-0073 349 µM -0.712483635037002 0.235982373794063 no 2595 0.238082670863886 3736 6740020
SGTC_638 3970-0837 4.09 µM -0.712753334076797 0.235899863795438 no 2596 0.237999203510089 3689 4118451 YLR208W SEC13
SGTC_2329 6138490 200 µM -0.712971571220582 0.235833109361547 no 2597 0.237931674497971 3730 720019
SGTC_2655 perillic acid 100 µM -0.713724361259397 0.235602925686264 no 2598 0.23769881968228 3702 5702197 An apoptosis inducer.
SGTC_3144 9087057 49.47 µM -0.713801277289229 0.235579413739039 no 2599 0.23767503487349 3613 17249618
SGTC_1759 st043059 70 µM -0.720660561715869 0.233487857730772 no 2600 0.235559191387733 3707 669426
SGTC_976 1348-1067 47.6 µM -0.723244748354331 0.232702558197427 no 2601 0.234764765574408 3751 5310671 YGL099W LSG1
SGTC_183 3914-0051 30.55 µM -0.724009569537488 0.232470421171169 no 2602 0.234529930047973 3711 1596232
SGTC_114 0364-0001 490.298 µM -0.725365257381551 0.232059262084866 no 2603 0.234113990577781 3744 4003655
SGTC_273 hydroxyurea 18.1 mM -0.725454648559931 0.232032165362064 no 2604 0.234086578775299 3768 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2773 thioridazine 9.09 µM -0.726635519652091 0.231674378906403 no 2605 0.233724631567619 3728 5452 An antipsychotic.
SGTC_2179 6298986 200 µM -0.726707426009714 0.231652602279537 no 2606 0.233702601671708 3659 738374
SGTC_2104 5389443 200 µM -0.728262926253698 0.23118180299262 no 2607 0.233226326131956 3752 2244536
SGTC_2024 5144227 134 µM -0.72930453988288 0.230866839137436 no 2608 0.232907697922006 3762 3475211
SGTC_2546 rhodinyl acetate 100 µM -0.730238726488876 0.230584563081887 no 2609 0.232622137300221 3687 6708682
SGTC_1238 0333-0287 48.8 µM -0.730637786168372 0.230464041071434 no 2610 0.23250021274923 3733 7226
SGTC_3082 9117008 49.47 µM -0.730784787071375 0.230419653469559 no 2611 0.232455308577419 3781 41448529
SGTC_3086 9117350 49.47 µM -0.732125320815372 0.230015093701652 no 2612 0.232046040120723 3650 2679265
SGTC_700 3453-2283 142 µM -0.732353448046738 0.229946286769675 no 2613 0.231976432245315 3778 565664
SGTC_1490 4089-0339 670 nM -0.73243521484546 0.229921627360834 no 2614 0.231951485783131 3681 742542
SGTC_2331 7980721 200 µM -0.734038548644178 0.229438389666933 no 2615 0.231462622131493 3706 2981221
SGTC_2754 granisetron 64.02 µM -0.734113120278971 0.229415927968327 no 2616 0.231439898895668 3706 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1501 4491-0275 38.4 µM -0.735329926898728 0.229049588207219 no 2617 0.231069293170902 3714 5104718
SGTC_1068 loratadine 26.9 µM -0.736419263486852 0.228721904002121 no 2618 0.230737792481462 3763 3957 A H1 histamine antagonist.
SGTC_519 k048-0011 62.8 µM -0.736507153290857 0.228695477280012 no 2619 0.230711057944718 3780 6836379
SGTC_2506 ethyl hematommate 54.16 µM -0.738365355707804 0.228137154110938 no 2620 0.230146230575452 3794 3940691 An allergen.
SGTC_2298 7976326 193.81 µM -0.741481642538332 0.227202544431658 no 2621 0.229200729197908 3632 2235818
SGTC_2129 girgensonine 121.053 µM -0.742420372435889 0.226921432228846 no 2622 0.228916340035503 3799 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1791 st048313 56.1 µM -0.74347797607813 0.22660495721436 no 2623 0.228596175313018 3684 1204976
SGTC_424 splitomicin 100 mM -0.743975050898793 0.226456299733054 no 2624 0.228445784480129 3806 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1469 k284-2957 126 µM -0.74431713291872 0.226354027108413 no 2625 0.228342319283239 3749 23884841
SGTC_2586 curcumin 80 µM -0.744596591423991 0.226270496467403 no 2626 0.228257814572895 3767 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1623 st003709 20.3 µM -0.744835283760816 0.2261991646972 no 2627 0.228185650957215 3735 16192618
SGTC_2220 6782180 200 µM -0.74645499090745 0.225715460732167 no 2628 0.227696305488 3667 833803
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.747546315773802 0.225389881324611 no 2629 0.227366928100559 3705 279621
SGTC_2596 sinensetin 100 µM -0.74868003990827 0.225051934536177 no 2630 0.227025038470172 3793 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1718 roemerine 11.9335 µM -0.749772480602332 0.224726565557251 no 2631 0.226695872829439 3652 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1568 digitonin 820 nM -0.754288198569475 0.22338445288132 no 2632 0.225338093561029 3755 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_946 3434-1334 87.4 µM -0.75598883019034 0.222880194275507 no 2633 0.224827946351715 3753 4047976
SGTC_84 0443-0269 128.823 µM -0.756102269353498 0.222846581228013 no 2634 0.224793940734755 3673 6150058
SGTC_2341 7987486 176.74 µM -0.756167901314698 0.222827135204773 no 2635 0.224774267597309 3753 1258686
SGTC_3227 9130768 49.47 µM -0.758701058556511 0.222077327946524 no 2636 0.224015701769008 3785 17720899
SGTC_1449 4112-4002 201 µM -0.759075460679018 0.221966628292035 no 2637 0.22390370878991 3780 2059539
SGTC_589 1227-0070 34.1 µM -0.760355364682783 0.221588436513766 no 2638 0.223521098083144 3794 2841384
SGTC_415 dibenzyl ketone 100 µM -0.761193982503889 0.221340837789066 no 2639 0.223270605956869 3800 7593
SGTC_2895 9054447 58.44 µM -0.761727772670807 0.221183320708714 no 2640 0.223111248004662 3798 2697450
SGTC_2536 dehydroabietamide 32.04 µM -0.761790659981155 0.221164767405192 no 2641 0.223092477864555 3786 3983547
SGTC_912 3474-0017 2.18 µM -0.762097067841585 0.221074382287747 no 2642 0.223001036373022 3801 3360550
SGTC_2362 9071156 126 µM -0.762624099543521 0.220918966339729 no 2643 0.222843803915043 3779 653133
SGTC_3281 9140613 49.47 µM -0.762752200774742 0.220881200123305 no 2644 0.222805596268014 3754 16013766
SGTC_2779 methotrexate 400 µM -0.763558769779103 0.220643496074543 no 2645 0.222565113662088 3811 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2452 5863136 48.41 µM -0.763682254462123 0.220607116827907 no 2646 0.222528309150045 3743 2184096
SGTC_2488 5268135 45.7 µM -0.763984025402194 0.220518227959789 no 2647 0.222438381164863 3829 1270356 YLR208W SEC13
SGTC_2566 crystal violet carbinol 226 nM -0.765983695691568 0.219929729075048 no 2648 0.221843001773507 3776 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_945 3381-0768 11.3 µM -0.76621214850751 0.219862553288064 no 2649 0.221775040492436 3805 1126236 YIL048W NEO1
SGTC_581 0958-0271 211 µM -0.766677224464458 0.219725835652696 no 2650 0.221636724139401 3804 4591145
SGTC_161 4065-0411 162.148 µM -0.768993517905593 0.219045645909642 no 2651 0.220948579306451 3834 1906281 YLR208W SEC13
SGTC_15 0266-0086 27.098 µM -0.770898700598649 0.218487089366938 no 2652 0.220383488699561 3860 1712902 YIL048W NEO1
SGTC_3121 9125696 49.47 µM -0.771684651807664 0.218256905404107 no 2653 0.220150611622769 3839 1235365
SGTC_449 xestospongin c 11.1929 µM -0.771773653724691 0.218230847947476 no 2654 0.220124249283912 3803 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1917 st066507 28.5 µM -0.772289168796893 0.21807995374931 no 2655 0.219971589508777 3758 3156428
SGTC_2442 5158906 48.48 µM -0.772427830823443 0.218039376850528 no 2656 0.219930537812839 3807 1893835
SGTC_524 r073-0010 27.8 µM -0.773216014787207 0.217808811968873 no 2657 0.21969727491991 3738 2772106
SGTC_290 2043-6722 48.1 µM -0.774330940351211 0.217482906715674 no 2658 0.219367555624786 3803 773758 YLR208W SEC13
SGTC_3266 9136860 49.47 µM -0.775504214807426 0.217140249603996 no 2659 0.219020887948036 3719 4871271 YPR165W RHO1
SGTC_2005 4024620 188 µM -0.77602640829867 0.216987842327164 no 2660 0.218866696693408 3779 236743
SGTC_823 0417-1665 178 µM -0.777039879382414 0.21669222737742 no 2661 0.218567621201607 3825 3429856
SGTC_11 0438-0307 1.3 µM -0.777343791219355 0.216603626079393 no 2662 0.218477982645589 3778 4011476
SGTC_2436 5633522 8.09 µM -0.778138663681433 0.216371991103229 no 2663 0.21824363576235 3763 5724242
SGTC_1771 st048882 4.1505 µM -0.778277197710624 0.216331635370578 no 2664 0.218202807535843 3813 4580403
SGTC_1634 st006576 41 µM -0.779928013713682 0.215851078901073 no 2665 0.217716624106653 3767 3915356
SGTC_2026 5148700 152 µM -0.780046698644101 0.21581655328906 no 2666 0.217681694190198 3791 79838
SGTC_124 0136-0217 7.121 µM -0.784008020012219 0.214666036805119 no 2667 0.216517702202481 3876 3976905
SGTC_784 4579-0127 173 µM -0.786912883475102 0.213824625405014 no 2668 0.215666432554145 3917 1948547
SGTC_2736 butenafine 14.65 µM -0.7872748357547 0.213719918450506 no 2669 0.215560498637522 3781 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1922 5578187 25 µM -0.787334151296884 0.213702762269809 no 2670 0.215543141415931 3793 1350412
SGTC_1242 0402-0103 60.1 µM -0.788272796218736 0.213431379327324 no 2671 0.215268578191854 3764 432868
SGTC_2850 9015429 58.44 µM -0.788705115269467 0.213306453954444 no 2672 0.215142188755357 3874 6457570
SGTC_462 ag-879 158 µM -0.788877561801255 0.213256634720405 no 2673 0.215091785649052 3831 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2830 7992007 71.43 µM -0.792222057866664 0.212291763468703 no 2674 0.214115604571764 3726 1952075
SGTC_2237 6667747 47.222 µM -0.7937253316446 0.211858908585424 no 2675 0.213677674905123 3798 729940 YDL015C TSC13
SGTC_517 1365-0151 113 µM -0.794004205557788 0.211778666033495 no 2676 0.213596491521926 3893 768657
SGTC_2249 haloperidol 116.36 µM -0.800087688947148 0.210032648178299 no 2677 0.211829996727165 3833 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.80098485173179 0.209775871445158 no 2678 0.211570207765108 3890 5024745
SGTC_50 0929-0078 56.389 µM -0.801191315463531 0.209716805646899 no 2679 0.21151044904215 3725 1377751
SGTC_98 0074-0023 107.663 µM -0.801701945278577 0.209570765059358 no 2680 0.211362695148704 3790 3563821
SGTC_3064 1327-0027 10 µM -0.802582292916286 0.209319125353429 no 2681 0.211108103129816 3707 16000455 YPR107C YTH1
SGTC_2156 5649887 115 µM -0.80381125341088 0.208968135261411 no 2682 0.210752994805818 3876 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_759 3486-0358 89.3 µM -0.803968102835772 0.208923364155495 no 2683 0.2107076983665 3817 875103
SGTC_2663 amphotericin b 100 µM -0.804585577906683 0.208747166964125 no 2684 0.210529433663726 3827 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2960 9079389 5.97 µM -0.805188167051779 0.208575301947955 no 2685 0.210355551884978 3822 16457355
SGTC_1345 1488-0192 31.4 µM -0.806407613069205 0.208227757940666 no 2686 0.210003929343192 3827 658348
SGTC_1340 1486-1359 257 µM -0.808041482255424 0.207762638693052 no 2687 0.209533351257866 3782 4309068
SGTC_60 0986-0278 202 µM -0.808445527027066 0.207647712570495 no 2688 0.209417076222908 3733 3110598
SGTC_1942 st076330 65.2 µM -0.808592001668773 0.207606058736552 no 2689 0.209374933480294 3865 24208414
SGTC_1734 st037168 69.4 µM -0.808960007396218 0.207501428624617 no 2690 0.209269075260059 3916 708907
SGTC_2289 7946404 165.07 µM -0.81500240730948 0.205787935751694 no 2691 0.207535466060873 3886 1246120 YPR165W RHO1
SGTC_1332 1480-0653 17.5 µM -0.816174296145493 0.205456588365987 no 2692 0.207200227840828 3811 5749438
SGTC_2428 5615643 7.78 µM -0.816996085082958 0.205224419573495 no 2693 0.206965332662336 3896 2253075
SGTC_2751 anetholtrithion 17.25 µM -0.818157064680557 0.204896689674074 no 2694 0.20663375398173 3863 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2775 cyproheptadine 69.59 µM -0.818821426763514 0.204709288705891 no 2695 0.206444152113263 3850 2913 A selective serotonin reuptake inhibitor.
SGTC_2862 9027634 71.43 µM -0.821867220587921 0.203851447721008 no 2696 0.205576235380962 3798 5012562
SGTC_443 clozapine 122 µM -0.82528098072582 0.202892520747932 no 2697 0.204606043562008 3751 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1878 temozolomide 1 mM -0.825562705235083 0.202813504725514 no 2698 0.204526099230825 3776 5394 DNA alkylating agent.
SGTC_2707 st078556 66.6 µM -0.825986351803311 0.202694718060838 no 2699 0.204405916995257 3847 17250899
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.828035519276955 0.202120737205502 no 2700 0.203825192329734 3894 229346 A bile salt which induces apoptosis.
SGTC_1717 st033143 58.0435 µM -0.828233636517081 0.202065295299358 no 2701 0.203769098994494 3863 674616
SGTC_1494 4358-1428 177 µM -0.828556529863646 0.201974955063991 no 2702 0.203677697271374 3879 1564571
SGTC_3217 9129673 49.47 µM -0.829870242581595 0.20160764925121 no 2703 0.20330607550951 3861 17248312
SGTC_2825 7998094 58.44 µM -0.831652070980876 0.201110101183226 no 2704 0.202802680744847 3879 2987815
SGTC_2126 5251174 33.877 µM -0.833480784217106 0.200600227747427 no 2705 0.202286815362373 3879 790722
SGTC_2053 5265679 138 µM -0.833578483939108 0.200573009417874 no 2706 0.202259277156227 3831 764595
SGTC_989 1501-0895 10.3 µM -0.834345289021948 0.200359460917025 no 2707 0.202043218941268 3820 2830112
SGTC_2177 5811945 192 µM -0.834378348114467 0.200350257321606 no 2708 0.202033907179688 3912 5343475
SGTC_3087 9117406 49.47 µM -0.834667351978582 0.200269809950779 no 2709 0.201952514337871 3874 42546093
SGTC_2957 9076800 11.52 µM -0.834747861396234 0.200247402735321 no 2710 0.201929843776216 3860 16459615
SGTC_1334 1486-0610 236 µM -0.835881904567461 0.199931938262137 no 2711 0.201610671653421 3951 3742339
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.836297087739429 0.19981651871996 no 2712 0.201493895551463 3933 5282362
SGTC_1131 3454-3128 32.3 µM -0.837455266891446 0.19949476066634 no 2713 0.201168355683533 3958 710982
SGTC_735 3076-0345 636 µM -0.838516135492499 0.199200310653471 no 2714 0.200870444702165 3941 2888990
SGTC_3239 9133757 49.47 µM -0.841025264922811 0.198504930265187 no 2715 0.200166890368833 3897 17036923
SGTC_2290 7904846 200 µM -0.841882090887123 0.198267805249997 no 2716 0.19992697790223 3954 2962154
SGTC_3196 9111891 49.47 µM -0.843633404986251 0.197783664448216 no 2717 0.19943714573439 3887 18891510
SGTC_1003 4049-0218 100 µM -0.845649109056602 0.197227319650592 no 2718 0.19887426046687 3926 295161
SGTC_2309 7664088 163.95 µM -0.845753475376383 0.197198539806552 no 2719 0.198845142274541 3897 704922
SGTC_2767 sibutramine 71.45 µM -0.846522002726494 0.19698669052188 no 2720 0.198630802374189 3883 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.846919732438689 0.196877107999876 no 2721 0.198519931524163 3984 4213774
SGTC_2183 6420625 130.508 µM -0.84777557037948 0.196641432654412 no 2722 0.198281485380111 3881 2897619
SGTC_3150 9097574 49.47 µM -0.849061511030294 0.196287639768343 no 2723 0.197923532917746 3905 17217476
SGTC_1331 1472-0049 76.2 µM -0.84983664161724 0.196074569423732 no 2724 0.197707957436841 3855 24051409
SGTC_1104 tacrolimus 29.8 µM -0.849845084223821 0.19607224946593 no 2725 0.197705610202361 3922 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2090 5301565 104.445 µM -0.850780349276467 0.195815349531061 no 2726 0.197445689766972 3907 2056344
SGTC_192 3455-0609 60.9 µM -0.852346258034745 0.195385681080073 no 2727 0.197010969387186 3971 3769639
SGTC_943 3253-1379 105 µM -0.853502210513354 0.195068867942314 no 2728 0.196690431168335 3872 668464
SGTC_1564 D-Arginine 115 µM -0.855975118421246 0.194392164808617 no 2729 0.196005771189555 3925 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2190 6049624 200 µM -0.858262261424023 0.193767569489324 no 2730 0.195373831535648 3794 2265554
SGTC_1061 3448-9325 110 µM -0.858478486708564 0.193708583946148 no 2731 0.195314152400465 3816 723482
SGTC_2205 7238770 200 µM -0.858738414591551 0.193637690971076 no 2732 0.195242425816198 3963 279867
SGTC_833 3852-0053 558 µM -0.862457299555977 0.192625132143755 no 2733 0.194217960468871 3980 3123681
SGTC_2461 5755302 26.15 µM -0.865074194425891 0.191914560972451 no 2734 0.193499033707136 3967 2788904
SGTC_892 0929-0076 29 µM -0.867250773224612 0.191324773727984 no 2735 0.192902311161333 3909 5751038
SGTC_2365 9042475 200 µM -0.867602814151605 0.191229485724856 no 2736 0.192805902669912 4009 6464479
SGTC_611 3453-1652 23.7 µM -0.867798455043055 0.191176543580272 no 2737 0.192752337980947 3898 1560575
SGTC_1156 4092-0367 4.88 µM -0.868123681635054 0.191088554294476 no 2738 0.19266331403375 3923 1357585
SGTC_924 2046-0044 21.3 µM -0.869122177679187 0.190818568747116 no 2739 0.192390153747866 3931 3623589
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.870248299033622 0.190514355307761 no 2740 0.192082363103825 3963 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1646 st011709 75.6 µM -0.871166082317068 0.190266643243503 no 2741 0.19183173824358 3860 5757843
SGTC_2993 9054257 71.4286 µM -0.871513522238312 0.19017291996926 no 2742 0.191736912900878 3881 6470217 YGL055W OLE1
SGTC_190 3970-0790 3.722 µM -0.872618941835876 0.189874917468987 no 2743 0.191435406282856 3845 2832352
SGTC_2544 sphondin 68.51 µM -0.872971721480209 0.189779874487682 no 2744 0.191339245727599 3898 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1350 1495-0454 146 µM -0.873824969807246 0.189550120344734 no 2745 0.191106790008452 3976 1069057
SGTC_2910 7948405 25.97 µM -0.87742302649509 0.188583155501056 no 2746 0.190128455330831 3828 2971328
SGTC_523 1934-0222 13.7 µM -0.878695419469539 0.188241933676224 no 2747 0.189783221454358 3917 1361595
SGTC_2878 9043973 25.97 µM -0.880080962822999 0.187870801513351 no 2748 0.189407725646135 4030 6465167
SGTC_3145 9085516 49.47 µM -0.880284597725907 0.187816293900402 no 2749 0.189352577159642 4004 25236195
SGTC_3344 9148862 3.898 µM -0.880894336645728 0.187653141525006 no 2750 0.189187506532812 3991 4905352
SGTC_3268 9137683 49.47 µM -0.881187926953789 0.187574614623125 no 2751 0.189108056364334 3967 1953228
SGTC_500 h-89 112 µM -0.882060240677378 0.187341415788485 no 2752 0.1888721157637 3984 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1684 st024538 14.6195 µM -0.882925231074334 0.187110351790469 no 2753 0.188638335144564 3922 6732859
SGTC_3198 9112019 49.47 µM -0.883619786431946 0.186924943583448 no 2754 0.188450747125997 3999 45595555
SGTC_1938 st074717 56.4 µM -0.884950763381221 0.186569963485067 no 2755 0.188091593678727 3783 17250979
SGTC_2235 salicylic acid 500 µM -0.885624050390245 0.186390552617387 no 2756 0.187910073601268 3968 338 A COX inhibitor and kinase inhibitor.
SGTC_3173 9105693 49.47 µM -0.88945596259352 0.185371498816317 no 2757 0.186879040146104 3957 17096658
SGTC_1344 1488-0097 29.1 µM -0.891346818584939 0.184869923981481 no 2758 0.186371569418942 3987 747966
SGTC_2491 paeonol 100 µM -0.891708805583905 0.18477399836972 no 2759 0.186274516261571 3814 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2433 5607874 27.82 µM -0.892791578539183 0.184487251092304 no 2760 0.185984398523193 3954 2252428
SGTC_1436 4092-1007 8.32 µM -0.893165460942243 0.184388301341413 no 2761 0.18588428573174 3938 2881121
SGTC_2591 skatole 100 µM -0.894085516098265 0.184144945010042 no 2762 0.185638069085714 4013 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_695 3505-6186 243 µM -0.89608822438439 0.183615916479994 no 2763 0.185102822864544 3982 1819379
SGTC_694 1315-0438 43.2 µM -0.89615704890469 0.183597752880437 no 2764 0.185084445795166 3928 6793154
SGTC_979 1426-2828 121 µM -0.900846879981952 0.182362689986998 no 2765 0.183834868957271 4079 747872
SGTC_3340 9146634 11.102 µM -0.901149493895172 0.182283175563098 no 2766 0.1837544202038 3999 4907387
SGTC_1638 st008370 60.6 µM -0.902925446298278 0.181816965493187 no 2767 0.183282732195946 3945 24207134
SGTC_522 1273-0010 11.6 µM -0.905910361742767 0.181035069301371 no 2768 0.182491649723951 4095 5705015
SGTC_2067 5224629 34.075 µM -0.906310667349318 0.180930370019736 no 2769 0.182385720454179 3981 2835000
SGTC_794 k038-0031 316 µM -0.906553496142048 0.180866877038284 no 2770 0.182321481579933 3975 6624242
SGTC_382 3229-0966 23.2 µM -0.907070476660215 0.180731747521625 no 2771 0.182184764638598 3997 5722370
SGTC_3209 9113616 49.47 µM -0.907119955492004 0.180718817954299 no 2772 0.182171683184116 4023 16649353
SGTC_647 0140-0236 81 µM -0.908159647798201 0.18044726476265 no 2773 0.181896940066587 3985 990837
SGTC_1352 1496-0991 99 µM -0.908199615059984 0.180436830980682 no 2774 0.181886383722559 3970 3000039
SGTC_1416 3966-0321 25.3 µM -0.908991022943618 0.180230305403988 no 2775 0.181677432210377 4007 582530 YLR208W SEC13
SGTC_3167 9103034 49.47 µM -0.909936934131197 0.179983655406045 no 2776 0.181427885084453 4027 5127859
SGTC_637 1181-0519 7.26 µM -0.910120236986873 0.179935883006375 no 2777 0.181379551570667 3991 6252091 YGR060W ERG25
SGTC_109 0132-0036 33.701 µM -0.910674155953967 0.179791569012824 no 2778 0.181233542558905 3795 67274 A color developer.
SGTC_255 tunicamycin 200.472 nM -0.911214897173734 0.179650758409519 no 2779 0.181091078132818 3918 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1293 1000-1278 195 µM -0.911376058770218 0.179608804864153 no 2780 0.181048631851435 4032 678847
SGTC_3213 9129884 49.47 µM -0.912316734702855 0.179364051212361 no 2781 0.180801003700617 3989 17190742
SGTC_493 zm226600 134 µM -0.912477577083747 0.179322222776984 no 2782 0.180758684027377 4034 5240098 A potassium channel opener. YCR052W RSC6
SGTC_954 1189-0853 2.85 µM -0.915254086645848 0.178601134801801 no 2783 0.18002912819575 3926 2828194
SGTC_2918 7977171 22.06 µM -0.916538313623951 0.178268226409483 no 2784 0.179692310852968 3928 2236483
SGTC_2278 7948257 134.34 µM -0.917164053129828 0.178106158603424 no 2785 0.179528340181772 3992 1247028
SGTC_836 0330-0104 1.35 µM -0.918971798604242 0.177638470836207 no 2786 0.179055161613151 3985 46494820
SGTC_1247 0448-0043 5.84 µM -0.919826036755613 0.177417737950715 no 2787 0.178831837464402 4038 3089013 YGL099W LSG1
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.923732311872481 0.176410574441215 no 2788 0.177812852282306 3976 803109
SGTC_186 3455-3465 67.277 µM -0.926796257776524 0.175623126915532 no 2789 0.177016164160133 3953 755278
SGTC_376 3970-0862 59.1 µM -0.927376536817428 0.175474243898641 no 2790 0.176865534240729 4048 3135186
SGTC_2852 9023854 51.95 µM -0.927462961016327 0.175452076766143 no 2791 0.176843107018752 4091 19798528
SGTC_2387 9077560 195.08 µM -0.927832528200812 0.175357305693651 no 2792 0.176747224004558 3981 5303272
SGTC_1219 1469-0211 33.1 µM -0.928333135008299 0.175228982849742 no 2793 0.176617395605433 4024 6822282
SGTC_1262 0737-0114 49.6 µM -0.93006993164485 0.174784243641289 no 2794 0.176167438891515 4081 765919
SGTC_554 4483-2211 187 µM -0.930433482809052 0.174691240342969 no 2795 0.17607334459931 4052 747107
SGTC_218 alverine citrate 93.75 µM -0.932755751724747 0.174097901357959 no 2796 0.175473046034602 4047 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_136 0097-0015 404.482 µM -0.933226867824031 0.173977687824082 no 2797 0.175351422604531 4009 4861337
SGTC_14 0354-0009 295 µM -0.933513238454438 0.173904641133097 no 2798 0.175277519227762 4077 1713507
SGTC_1713 st033146 12.748 µM -0.933772332959401 0.173838568774426 no 2799 0.175210671994198 4000 674619
SGTC_372 0155-0182 15.9 µM -0.935086416920135 0.173503706707804 no 2800 0.174871883018375 3928 771486
SGTC_56 0957-0365 83.25 µM -0.93685115886219 0.173054651820506 no 2801 0.17441756273697 4007 6752360
SGTC_3058 9093861 49.47 µM -0.938236902744852 0.172702555904992 no 2802 0.174061338851093 4019 17217477
SGTC_3228 9131799 49.47 µM -0.938536298956374 0.172626544029208 no 2803 0.173984435874864 4012 17015818
SGTC_3282 9108498 15.4605 µM -0.938701356888519 0.172584647601487 no 2804 0.173942048297577 4020 16459645
SGTC_2705 st078069 42.8 µM -0.93902966524597 0.172501332818638 no 2805 0.173857756840253 4075 1530061
SGTC_2833 9001315 45.46 µM -0.940602544957379 0.17210253915977 no 2806 0.173454288618393 3998 2989378
SGTC_1058 3448-5425 97.3 µM -0.942267007788527 0.171681166556461 no 2807 0.173027977475941 3891 7279705
SGTC_2259 7964009 200 µM -0.942753770070276 0.171558063293254 no 2808 0.172903431563175 4072 313134
SGTC_2143 5623677 140.463 µM -0.943099515542135 0.171470657762948 no 2809 0.172815001763497 3944 5375313
SGTC_1292 0kpi-0043 232 µM -0.94389141729567 0.171270569800409 no 2810 0.172612569171541 4040 3333905
SGTC_1775 st081588 35.1725 µM -0.94467179472926 0.171073539755484 no 2811 0.172413230493032 4026 1426443 YGL099W LSG1
SGTC_115 0527-0192 112.043 µM -0.946135655862788 0.170704334652648 no 2812 0.172039699795034 4027 4233931
SGTC_2390 9097792 176.6 µM -0.9479297868764 0.170252527283924 no 2813 0.171582599864204 4023 4497149
SGTC_2412 st077135 33.4 µM -0.948403248016411 0.170133425727133 no 2814 0.171462103276703 4126 13258915
SGTC_335 4077-0256 27.6 µM -0.950721440448647 0.169551043592324 no 2815 0.170872900640413 4019 3121989
SGTC_599 1935-0052 86.5 µM -0.951885967148631 0.169258971479059 no 2816 0.17057740853799 4026 9557311
SGTC_470 aa-861 153 µM -0.95253428866851 0.169096507581241 no 2817 0.170413042456023 4023 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_621 3584-0052 32.1 µM -0.953376401330181 0.168885630828724 no 2818 0.170199696868607 4033 2273927
SGTC_155 k072-0202 43.6 µM -0.956728768967965 0.168047827122506 no 2819 0.169352086687358 3933 5857737
SGTC_133 0724-0033 378.92 µM -0.957054217161191 0.167966635725921 no 2820 0.1692699451282 3885 280309
SGTC_1750 st081859 2.357 µM -0.958519813683153 0.167601318025248 no 2821 0.168900352609946 3999 5291695
SGTC_1844 rapamycin 4 nM -0.959067052905063 0.167465043337274 no 2822 0.168762483454955 3951 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_236 1509-0011 5.31 µM -0.96159305343954 0.166836938866724 no 2823 0.16812703113824 4103 3107280
SGTC_2639 lactacystin 53 µM -0.962026260960426 0.166729372205417 no 2824 0.168018206318167 4099 3870 A proteasome inhibitor.
SGTC_2181 6316240 54.2555 µM -0.963270559632041 0.166420658224681 no 2825 0.167705881785708 4066 12779990
SGTC_1507 4075-3230 155 µM -0.963525812272873 0.166357374979085 no 2826 0.167641858475612 3917 659771
SGTC_46 0329-0187a 2.197 µM -0.964424064945626 0.166134800195489 no 2827 0.167416680965546 4103 46494817
SGTC_2253 7938677 135.83 µM -0.965442607145974 0.165882652162775 no 2828 0.167161584706358 4129 2301972
SGTC_2680 butyl paraben 22.24 µM -0.966221146293929 0.165690085631469 no 2829 0.166966766833954 4109 7184 An antifungal and steroid mimetic.
SGTC_3199 9111318 49.47 µM -0.969090861667752 0.164981529319452 no 2830 0.166249928381456 4009 8548020
SGTC_2076 5212012 200 µM -0.970232138485638 0.164700284802978 no 2831 0.165965397247501 3991 604802
SGTC_2476 5806916 10.51 µM -0.97146108530455 0.16439778332878 no 2832 0.165659361251796 3917 2870194
SGTC_4 0960-0234 25.671 µM -0.972296885143069 0.164192259678447 no 2833 0.165451436500625 4060 6821112
SGTC_3165 9101544 49.47 µM -0.973037262686693 0.164010339668025 no 2834 0.165267391352564 4073 5002184
SGTC_705 1124-0212 310 µM -0.973463791302871 0.163905595649561 no 2835 0.165161423832539 4017 9554485
SGTC_2572 astragaloside iv 100 µM -0.974712984103496 0.163599077105082 no 2836 0.164851325257123 4125 45006101 An anti-inflammatory agent.
SGTC_3017 9080681 49.47 µM -0.976474326899554 0.163167523414643 no 2837 0.164414732122361 4077 16451914
SGTC_3318 9139014 38.6185 µM -0.97679200783035 0.163089765950607 no 2838 0.164336066769791 4054 16643984
SGTC_2714 st079313 56.9 µM -0.977449278423803 0.16292896498813 no 2839 0.164173388428272 4029 2939799
SGTC_3009 9080819 71.4286 µM -0.978885848706144 0.162577867689153 no 2840 0.163818192561327 4084 17027216
SGTC_3183 9108214 49.47 µM -0.98056162449233 0.162168931137652 no 2841 0.163404483219226 3995 4974831
SGTC_1655 st012546 55.1 µM -0.983157991281058 0.161536668356047 no 2842 0.162764843247859 4059 720985 YLR208W SEC13
SGTC_685 1278-0033 54.9 µM -0.984063400929352 0.16131656300375 no 2843 0.162542170330539 4119 3590572
SGTC_3316 9136639 10.545 µM -0.984070154231043 0.161314922009439 no 2844 0.162540510194948 4080 4903665
SGTC_1652 st011932 78 µM -0.985427837994367 0.160985237644772 no 2845 0.162206980606176 4021 1551076
SGTC_1581 himbacine 57.9 µM -0.986860544805082 0.160637812770174 no 2846 0.161855504374251 4066 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_938 3126-1755 342 µM -0.986894749257499 0.160629524335873 no 2847 0.161847119297531 4075 1777771
SGTC_1772 st048439 82.2 µM -0.989470508708663 0.160006167974092 no 2848 0.161216495989378 4132 2927068 YDL195W SEC31
SGTC_1916 st067606 49.2 µM -0.990653107251562 0.159720499355819 no 2849 0.160927498001681 4033 19590279
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.994113824038336 0.158886446637284 no 2850 0.160083727957321 4127 688788
SGTC_2277 7947813 106.88 µM -0.99707884597885 0.158174133771207 no 2851 0.15936312007005 4159 1246798
SGTC_422 cantharidin 155 µM -0.997719973600985 0.15802038615054 no 2852 0.159207582515476 4013 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.998520515626072 0.157828547439913 no 2853 0.15901351065895 4098 115019
SGTC_1827 berberine 7.24 µM -0.998860947904446 0.157747013971941 no 2854 0.158931028163458 4021 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_173 1273-0061 2.693 µM -0.998916688408152 0.157733666767854 no 2855 0.158917525606255 4067 2847414 YPL266W DIM1
SGTC_442 cape 100 µM -1.00152554231995 0.157109800001446 no 2856 0.158286398917642 4065 5281787
SGTC_535 2293-4129 48.2 µM -1.00156822015529 0.157099607771217 no 2857 0.158276088105205 4099 396118 YIL048W NEO1
SGTC_441 propafenone 146 µM -1.0020804331574 0.156977316076937 no 2858 0.158152373661771 4069 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_876 0720-0963 56.8 µM -1.00284920712397 0.156793887592977 no 2859 0.157966811374938 4122 765861
SGTC_1113 artemisinin 1.17947 µM -1.00315239665781 0.1567215857567 no 2860 0.157893668530909 4141 2240 An anti-malaria and mitochondrial poison.
SGTC_2643 anethole 100 µM -1.00456817996162 0.156384253368157 no 2861 0.157552412862619 4078 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1103 duloxetine 36.1 µM -1.00537945466081 0.156191170232858 no 2862 0.157357084511627 4191 60835 A selective serotonin reuptake inhibitor.
SGTC_2877 9040724 71.43 µM -1.00585199605183 0.156078777940469 no 2863 0.157243385430802 4090 6463895
SGTC_2439 5492030 7.2 µM -1.00602152862467 0.156038468213523 no 2864 0.157202607045853 4084 5722370
SGTC_478 N-arachidonylglycine 10 µM -1.01029352569447 0.15502498115745 no 2865 0.156177341041649 4049 5283389
SGTC_914 3820-6779 408 µM -1.01089080496556 0.154883629973612 no 2866 0.156034347709682 4053 2893481
SGTC_3094 9117742 49.47 µM -1.0111436394393 0.154823820213833 no 2867 0.155973843159266 4029 17149698
SGTC_1273 0849-0096 14.1 µM -1.01139483400243 0.15476441349754 no 2868 0.155913746363622 4121 5286025
SGTC_2269 7935389 174.42 µM -1.01262666640669 0.154473307081183 no 2869 0.155619258825037 4051 97605
SGTC_584 0986-0246 15.4 µM -1.01458354607203 0.154011602333809 no 2870 0.155152192957534 4191 53315 YDR232W HEM1
SGTC_2032 5185112 25.99 µM -1.01489132925273 0.153939067380423 no 2871 0.155078815922717 3973 5718189
SGTC_27 0485-0001 32.618 µM -1.01540816390712 0.153817316336248 no 2872 0.154955651532475 4034 2054479
SGTC_826 1683-5028 118 µM -1.01669379068511 0.153514737008883 no 2873 0.154649560264703 4149 722377
SGTC_446 go6976 132 µM -1.01891349723866 0.152993245332099 no 2874 0.154122017660484 4134 3501 A protein kinase C inhibitor.
SGTC_571 k831-0106 44.2 µM -1.02018610906406 0.152694791747788 no 2875 0.153820102155931 3980 4783639
SGTC_38 0929-0051 58.268 µM -1.02207389311942 0.152252779463266 no 2876 0.153372964189698 4113 1379719
SGTC_2311 7694451 200 µM -1.02231764969174 0.152195767443032 no 2877 0.153315291171484 4093 2163142
SGTC_1679 SEC14.276 6.7 µM -1.02436553827131 0.151717348344941 no 2878 0.152831326434672 4111 1005053 YMR079W SEC14
SGTC_595 3909-8003 73.7 µM -1.02508346203992 0.151549866879401 no 2879 0.152661904084831 4179 699517
SGTC_3168 9103419 49.47 µM -1.0259202924583 0.151354801361709 no 2880 0.152464578345635 4117 16649256
SGTC_2688 kanamycin b 96.69 µM -1.02605204864038 0.151324104162405 no 2881 0.152433525490254 4177 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2602 kawain 100 µM -1.02651688160464 0.151215838181751 no 2882 0.152324005215466 4118 5369129
SGTC_1458 k015-0034 6.33 µM -1.0280381429096 0.15086187587745 no 2883 0.151965942911684 4154 3598957
SGTC_134 0269-0018 6.916 µM -1.02821725015759 0.150820238085703 no 2884 0.151923822900033 4095 4378915
SGTC_1386 3228-0095 33.8 µM -1.03230551271239 0.149871903391426 no 2885 0.150964509703547 4134 870181
SGTC_3049 9092223 49.47 µM -1.03631250666228 0.148946287459403 no 2886 0.150028186658549 4108 8623917
SGTC_41 0478-0632 82.643 µM -1.03666486699834 0.148865075286729 no 2887 0.149946035462624 4064 3750424
SGTC_933 2914-0560 114 µM -1.03689848093657 0.148811248153674 no 2888 0.149891585984574 4177 463887
SGTC_2478 5763493 32.33 µM -1.03732208035634 0.148713679526403 no 2889 0.149792889350407 4054 1365576 YLR208W SEC13
SGTC_2166 5933061 31.504 µM -1.03751633924191 0.148668949735223 no 2890 0.149747642462616 4265 2877375
SGTC_432 NS 1619 61.3 µM -1.03756847475257 0.148656946613169 no 2891 0.149735500582456 4145 4552 A K+/calcium channel activator.
SGTC_2334 9017922 200 µM -1.04012353077829 0.148069491677377 no 2892 0.149141256344491 4193 3163164
SGTC_1035 k081-0041 55.2 µM -1.04084760145733 0.147903297261078 no 2893 0.14897314183143 4161 731709
SGTC_2796 7949634 45.45 µM -1.04287864285785 0.147437783262639 no 2894 0.148502251114069 4103 2971588
SGTC_3040 9091894 49.47 µM -1.04388795396454 0.147206815045098 no 2895 0.148268616031622 3987 25236966
SGTC_2973 9094665 17.96 µM -1.05285248267316 0.145166041498031 no 2896 0.146204303458231 4190 25237061 YIL048W NEO1
SGTC_2318 6029776 164 µM -1.05374378597774 0.144964182080504 no 2897 0.146000118187967 4201 818325
SGTC_2380 9035439 200 µM -1.05390790609688 0.14492703331085 no 2898 0.14596254143438 4246 6462575
SGTC_1359 1582-0056 520 nM -1.0578349818115 0.144040046766444 no 2899 0.14506534069886 4205 3661189
SGTC_1743 st037606 46.3785 µM -1.05824633588764 0.143947348804716 no 2900 0.144971575779455 4133 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1230 0170-0365 3.77 µM -1.05848263694279 0.143894116952507 no 2901 0.144917731270804 4206 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2564 betulinic acid 100 µM -1.05870136355666 0.143844855953703 no 2902 0.144867903345943 4213 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2948 9070189 9.45 µM -1.06070244731277 0.143394705635787 no 2903 0.144412573717872 4104 6473636 YDL196W YDL196W
SGTC_865 0488-0499 301 µM -1.06128845553709 0.143263061424763 no 2904 0.144279415288345 4123 9634651
SGTC_511 blebbistatin 171 µM -1.0635158199422 0.142763438540981 no 2905 0.143774047414756 4219 3476986 A myosin inhibitor.
SGTC_221 trifluoperazine 10.304 µM -1.06566902814824 0.142281570703372 no 2906 0.143286641549121 4126 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1688 st021091 57.6 µM -1.06847085531199 0.141656197428899 no 2907 0.142654085125647 4186 3656366
SGTC_2496 diffractaic acid 79.83 µM -1.06963675793175 0.141396515140983 no 2908 0.14239142147966 4188 94870 An apoptosis inducer which activates caspases.
SGTC_2394 5221648 200 µM -1.0699528642785 0.14132616418924 no 2909 0.142320262985888 4205 788586
SGTC_593 1203-0218 61.7 µM -1.07079331473492 0.141139233409477 no 2910 0.142131186768295 4189 3666956
SGTC_1863 st057641 20.1 µM -1.07404315606539 0.140417990258916 no 2911 0.141401669856971 4185 3921635
SGTC_1879 gemcitabine 100 µM -1.07634406238449 0.13990886164529 no 2912 0.140886704706885 4148 60750 A nucleoside analog which inhibits DNA replication.
SGTC_745 0469-0705 296 µM -1.07847642065756 0.139438149603953 no 2913 0.140410599477614 4237 3486736
SGTC_679 0422-0091 41.4 µM -1.07995216842219 0.139113013929832 no 2914 0.140081740231996 4182 627384 YHR062C RPP1
SGTC_2732 terfenadine 20 µM -1.08055458941144 0.138980437411291 no 2915 0.139947645794845 4229 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1780 st038448 24.544 µM -1.08078718109404 0.13892927331573 no 2916 0.139895895963811 4217 728868 YDL195W SEC31
SGTC_3191 9110352 49.47 µM -1.08087672378777 0.138909579681093 no 2917 0.139875976882173 4119 17122424
SGTC_2417 cerulenin 830 nM -1.08162734111805 0.138744566890835 no 2918 0.139709075273872 4200 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1037 k284-1091 78.7 µM -1.08182083629823 0.138702051317473 no 2919 0.139666073104346 4151 3334711
SGTC_623 k072-0108 16.9 µM -1.08431702323484 0.138154374304391 no 2920 0.139112130001201 4140 5382803
SGTC_259 usnic acid 108.925 µM -1.0848792829743 0.138031215209795 no 2921 0.138987562368215 4262 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_803 4488-1585 147 µM -1.08638696652507 0.137701337271227 no 2922 0.138653912707484 4165 747204
SGTC_2420 aureobasidin a 50 nM -1.08765009116599 0.137425382804085 no 2923 0.138374804194473 4294 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_799 1310-0557 151 µM -1.08803796609742 0.137340719711548 no 2924 0.138289173645621 4245 5354492
SGTC_1304 1165-0502 251 µM -1.08829416595979 0.137284817427399 no 2925 0.138232632612418 4174 767425
SGTC_1505 k297-0037 20.6 µM -1.08906596892592 0.137116505536284 no 2926 0.138062397819496 4186 4089396
SGTC_2696 st077691 74.316 µM -1.09097480097674 0.136700840293938 no 2927 0.137641985426409 4249 757133
SGTC_48 0382-0018 55 µM -1.09212656782586 0.136450449932835 no 2928 0.13738873661192 4248 762596
SGTC_104 0074-0074 590.992 µM -1.09329496746112 0.136196764386515 no 2929 0.137132155888752 3957 3943124
SGTC_1336 1486-0901 104 µM -1.09477259419093 0.135876401231462 no 2930 0.136808137896252 4213 5006114
SGTC_2413 inermin 26.06 µM -1.09517227744504 0.135789834936719 no 2931 0.136720584266312 4275 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_350 k064-0020 19.8 µM -1.09536172408981 0.13574881640722 no 2932 0.136679097935601 4221 2790705
SGTC_2766 oltipraz 83.91 µM -1.09580222662323 0.135653472674194 no 2933 0.136582666935025 4168 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_401 neomycin 50 µM -1.09853350186231 0.1350633310814 no 2934 0.13598579846636 4155 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.09901184301517 0.134960158242037 no 2935 0.135881450101592 4282 688801
SGTC_1911 st060208 74.3 µM -1.0991900215311 0.134921740950041 no 2936 0.135842595132095 4226 688783
SGTC_1217 1183-1422 255 µM -1.1011518691033 0.134499240546256 no 2937 0.135415282718627 4226 2849664
SGTC_3187 9109394 49.47 µM -1.10262141125224 0.134183357848158 no 2938 0.135095804029748 4199 17098090
SGTC_815 1582-0027 36.9 µM -1.10403555729017 0.133879864215043 no 2939 0.1347888568334 4232 3128206
SGTC_194 1486-1323 56.904 µM -1.1042812060837 0.133827193007097 no 2940 0.134735586400432 4268 5178754
SGTC_2738 aclarubicin 5.55 µM -1.10492953166408 0.133688249572687 no 2941 0.134595062445888 4163 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2647 atorvastatin 60.16 µM -1.10544197165751 0.133578498141663 no 2942 0.134484062766319 4164 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_563 tetrahydrosecaminediol 614 µM -1.10700809667033 0.133243458665022 no 2943 0.134145213868351 4260 334274 A psychoactive constituent of the cannabis plant.
SGTC_2982 9019404 25.97 µM -1.1088106412697 0.13285855849386 no 2944 0.133755939456212 4139 22333232
SGTC_2462 5162487 171.77 µM -1.10955775980029 0.13269924974883 no 2945 0.133594820890843 4141 2259986
SGTC_2907 7721985 69.9 µM -1.11104036594353 0.132383502071008 no 2946 0.133275487327564 4223 3267881
SGTC_2453 5731132 22.18 µM -1.11204073957138 0.132170747266608 no 2947 0.133060317176927 4257 1362040
SGTC_1861 st057647 17.4 µM -1.1121822393688 0.132140672789659 no 2948 0.133029901329488 4295 688668
SGTC_2811 7967822 32.47 µM -1.11222026288271 0.132132592046815 no 2949 0.133021728865846 4254 2232244
SGTC_1428 4049-0204 61.7 µM -1.11337496459376 0.131887357547465 no 2950 0.132773711306807 4261 X1428
SGTC_2207 7258803 200 µM -1.11582581208992 0.131367889680657 no 2951 0.13224835134188 4199 3666799
SGTC_384 k007-0144 5.16 µM -1.1170869471718 0.131101137799496 no 2952 0.131978575469393 4148 6824886
SGTC_2370 9071495 200 µM -1.11801594817494 0.13090487751586 no 2953 0.131780091036117 4218 21791103
SGTC_65 0798-0905 34.986 µM -1.11869446317911 0.130761663138251 no 2954 0.131635254049273 4306 3602145
SGTC_573 3702-0553 84.7 µM -1.12145421240508 0.130180278285353 no 2955 0.131047285545814 4171 1222756
SGTC_852 0418-0143 439 µM -1.12393123196499 0.129659980235347 no 2956 0.130521100270465 4220 5369229
SGTC_636 0kpi-0074 126 µM -1.12454220937707 0.129531866161077 no 2957 0.130391537256312 4221 616434
SGTC_2505 galangin 7.89 µM -1.12642829531476 0.129136931626895 no 2958 0.129992137820667 4110 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_178 4092-0806 87.505 µM -1.12930093703316 0.12853702390027 no 2959 0.129385452882442 4109 2169044
SGTC_1434 4073-0095 163 µM -1.12952676451155 0.128489945390461 no 2960 0.129337842779661 4180 24133745
SGTC_1704 st028805 70.8 µM -1.1326970254216 0.12783030072588 no 2961 0.128670753630543 4268 2876101
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -1.13361280274681 0.127640191360203 no 2962 0.128478500154815 4322 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_253 dyclonine 31.25 µM -1.13605715758794 0.127133722101013 no 2963 0.127966321847554 4327 3180 An oral anasthetic.
SGTC_530 4358-1714 28 µM -1.1377481967882 0.126784158891829 no 2964 0.127612820893826 4229 1564641
SGTC_1824 st053723 68.6 µM -1.13958767678334 0.12640467127648 no 2965 0.127229060887839 4261 675225
SGTC_3079 9117512 49.47 µM -1.14024913446059 0.126268405173304 no 2966 0.127091261283396 4288 7185044
SGTC_1799 st045822 46.1415 µM -1.14057658587529 0.126200985198143 no 2967 0.127023082705098 4217 3674992
SGTC_3140 9094243 49.47 µM -1.14343914188103 0.125612673114934 no 2968 0.126428154459245 4210 19291112
SGTC_2285 7945142 200 µM -1.14607506518896 0.125072633321368 no 2969 0.125882046903592 4280 2970608
SGTC_1183 1254-0324 198 µM -1.14682835148218 0.124918600724528 no 2970 0.12572628461197 4313 5799357
SGTC_2954 9074818 52.69 µM -1.15000762554472 0.124269960405822 no 2971 0.125070365267808 4264 16648742
SGTC_3080 9117754 49.47 µM -1.15228097320719 0.123807595462758 no 2972 0.124602816479593 4249 9550191
SGTC_1118 chelidonine 707.474 nM -1.15236809187052 0.123789900819351 no 2973 0.124584923531241 4231 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1479 0549-0158 134 µM -1.15307552963594 0.123646278922041 no 2974 0.124439692274109 4302 5440202
SGTC_24 0417-1663 219 µM -1.15354746670658 0.123550532577765 no 2975 0.124342873258644 4267 4329390
SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.15656616929125 0.122939328084584 no 2976 0.123724825411141 4344 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2255 7941087 197.44 µM -1.1568118098051 0.122889686052717 no 2977 0.123674627877255 4349 935561
SGTC_1830 st055982 50.3 µM -1.15863984685497 0.122520695519501 no 2978 0.123301509778872 4217 455313 An antimicrobial agent.
SGTC_341 1486-1430 230 µM -1.16019859383078 0.122206675992023 no 2979 0.122983979686092 4204 2054753 YPL210C SRP72
SGTC_851 0394-0702 453 µM -1.16222866899588 0.121798552148035 no 2980 0.122571296136205 4258 762646
SGTC_2650 prasterone 100 µM -1.16287737105205 0.121668339991582 no 2981 0.122439629895553 4244 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2233 sulbentine 40.3845 µM -1.16392950367125 0.121457356401405 no 2982 0.122226290958815 4259 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_1755 st041960 45.185 µM -1.16446505077861 0.121350062263024 no 2983 0.12211779936693 4290 2257073
SGTC_2055 5235184 200 µM -1.16486044994811 0.121270888829549 no 2984 0.122037742468007 4292 2836034
SGTC_972 1319-0219 195 µM -1.16560294116809 0.121122312992525 no 2985 0.121887509070451 4230 23903702
SGTC_394 menadione 8.33 µM -1.17122139895891 0.120002184042239 no 2986 0.120754897988303 4245 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2064 5220758 200 µM -1.17405468450489 0.119440101267289 no 2987 0.120186561364147 4320 788518
SGTC_275 trichlorophene 5.69 µM -1.17802990939358 0.118654609679558 no 2988 0.119392341302814 4300 62616
SGTC_1999 st074831 12.5 µM -1.17909083913901 0.118445591819721 no 2989 0.119181003011042 4236 17112523
SGTC_2788 5282734 71.43 µM -1.17928019087261 0.118408314290624 no 2990 0.119143311739717 4345 743706
SGTC_983 1491-0821 12.2 µM -1.18328591832377 0.117621652583716 no 2991 0.118347925858251 4261 46495113
SGTC_334 1502-1024 68.5 µM -1.1861182504896 0.117067664524106 no 2992 0.117787802061232 4279 3296216
SGTC_1933 st074711 15.9 µM -1.18618651122074 0.117054335967555 no 2993 0.117774325966083 4252 17250958
SGTC_444 curcumin 90.4 µM -1.18630523214112 0.117031157140877 no 2994 0.117750890573931 4205 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2922 7999257 32.47 µM -1.18696175581187 0.116903037541039 no 2995 0.11762135303712 4243 2988377
SGTC_1121 fusaric acid 630.51 nM -1.18731115211082 0.116834893927712 no 2996 0.117552455406153 4231 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1946 st076057 65.1 µM -1.18827176866524 0.116647687674283 no 2997 0.117363178221071 4217 953009
SGTC_1821 st053465 65.6 µM -1.19405623212915 0.11552489981967 no 2998 0.116227986194408 4288 675086
SGTC_2213 7173844 200 µM -1.19502618445861 0.115337382421168 no 2999 0.116038399945605 4271 892728
SGTC_542 3381-0244 89.3 µM -1.19576667002816 0.115194372698136 no 3000 0.115893812958469 4291 1112843
SGTC_1276 0871-0068 94.2 µM -1.19638764999602 0.115074540274404 no 3001 0.115772659255626 4289 3414906
SGTC_909 3448-9333 149 µM -1.19653386843863 0.11504633694747 no 3002 0.115744145005156 4211 3344074
SGTC_3322 9139058 2.11 µM -1.19758228850755 0.114844256541051 no 3003 0.115539837328057 4335 4908926 YPR165W RHO1
SGTC_658 3253-0951 102 µM -1.19778467594915 0.114805275950835 no 3004 0.115500427213666 4276 1184878
SGTC_2312 7706453 155.7 µM -1.19893026920137 0.114584807767165 no 3005 0.115277530369856 4276 976098
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.20204551816934 0.11398680573719 no 3006 0.114672946497382 4324 688664
SGTC_2671 danthron 100 µM -1.20593394014289 0.113243509865321 no 3007 0.113921481367023 4286 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_3207 9114163 49.47 µM -1.20916531809007 0.112628447930323 no 3008 0.113299669521994 4312 849233
SGTC_2531 methyl deoxycholate 70.07 µM -1.21087778593524 0.112303464919311 no 3009 0.112971123725628 4242 16667744 Haematoxylin.
SGTC_3303 9125618 40.5795 µM -1.21141622128956 0.11220142213318 no 3010 0.112867962776453 4299 22695467
SGTC_608 k048-0125 159 µM -1.2118969819205 0.112110365718134 no 3011 0.112775908799717 4337 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2880 9042983 58.44 µM -1.21334601447055 0.11183623747184 no 3012 0.112498778590565 4257 6464714
SGTC_2583 asiatic acid 100 µM -1.21662713055539 0.11121728783326 no 3013 0.111873057701239 4332 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_3022 9087993 49.47 µM -1.21678708870263 0.111187176155471 no 3014 0.111842616847682 4373 17173644
SGTC_477 mead ethanolamide 10 µM -1.21832905007979 0.110897205523018 no 3015 0.111549477467849 4232 16061185
SGTC_1225 1216-0074 20.6 µM -1.219092892581 0.110753763386554 no 3016 0.111404468602565 4310 4241466
SGTC_896 0964-0007 44.5 µM -1.22023065394189 0.110540349530928 no 3017 0.111188724722271 4274 6756758
SGTC_1286 0929-0070 131 µM -1.2256111247847 0.109535108976575 no 3018 0.110172524700809 4378 1420408
SGTC_1596 piperlongumine 63 µM -1.22796600056383 0.109097215866899 no 3019 0.109729865687472 4342 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1651 st011928 86.1 µM -1.22824261591488 0.109045861463425 no 3020 0.109677952684941 4310 720198
SGTC_154 3389-1638 511.116 µM -1.22904839805775 0.108896364810875 no 3021 0.109526830300517 4315 5238686
SGTC_1838 st055369 84.5 µM -1.23097743673351 0.108539069259712 no 3022 0.109165651647292 4303 676036
SGTC_193 1273-0060 1.558 µM -1.23489768623089 0.10781556267924 no 3023 0.108434292343494 4150 2847393 YHR072W ERG7
SGTC_1138 3761-0006 1.03 µM -1.23558295130362 0.107689450236525 no 3024 0.108306812547989 4345 12061087
SGTC_1992 st073643 23.3 µM -1.2370848618638 0.107413418615485 no 3025 0.108027789598244 4296 3161292
SGTC_2150 5556613 200 µM -1.23787153549288 0.107269041920859 no 3026 0.107881849128914 4335 743190
SGTC_165 k038-0023 64.381 µM -1.23807264846944 0.107232154510842 no 3027 0.10784456227435 4315 46368543
SGTC_1351 1496-0003 46.5 µM -1.23911319846589 0.107041446694594 no 3028 0.107651789922052 4335 3891978
SGTC_3313 9133968 57.047 µM -1.24055112569508 0.106778311956069 no 3029 0.107385808211407 4310 1494643
SGTC_1781 st038725 66.3 µM -1.24231449094069 0.106456260999089 no 3030 0.107060275431844 4309 4270275 YIL048W NEO1
SGTC_2184 6075246 200 µM -1.242663143424 0.106392668227711 no 3031 0.106995995472048 4303 2267320
SGTC_644 1498-1197 63.3 µM -1.24505539258686 0.105957071585401 no 3032 0.106555694758791 4340 6741615
SGTC_829 1635-0120 117 µM -1.24591657338764 0.105800577970075 no 3033 0.106397512439301 4330 285054
SGTC_2570 licareol 100 µM -1.24626495088415 0.105737318363447 no 3034 0.106333570400596 4305 443158
SGTC_2154 5570129 200 µM -1.24908483112799 0.105226280845067 no 3035 0.10581702404669 4373 673366
SGTC_487 nimodipine 119 µM -1.2528264949939 0.10455095378861 no 3036 0.105134428551984 4321 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2407 paclitaxel 400 µM -1.25487488292481 0.104182576119068 no 3037 0.104762091618569 4408 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1067 clotrimazole 1.36 µM -1.25542454550034 0.104083886292453 no 3038 0.104662341757555 4370 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_612 0302-0167 22.4 µM -1.25736600120763 0.103735847829918 no 3039 0.104310567255392 4340 235821
SGTC_2558 carylophyllene oxide 100 µM -1.25990032757476 0.10328279881423 no 3040 0.103852660281506 4449 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2066 5222451 176 µM -1.262079001744 0.102894477745723 no 3041 0.103460180153038 4284 2281147
SGTC_1320 1313-0481 95.3 µM -1.26232317298397 0.102851023506934 no 3042 0.103416260782808 4306 6813365 YLR208W SEC13
SGTC_974 1326-0144 138 µM -1.26700426666173 0.102020523584369 no 3043 0.102576882141521 4362 5411856
SGTC_1705 st027868 56.3335 µM -1.27092096669937 0.101329397454971 no 3044 0.101878383281456 4279 292948
SGTC_1559 coumarin 343 70.1 µM -1.27266013033017 0.101023607172865 no 3045 0.101569335607495 4370 108770 A hepatotoxic, DNA x-linker.
SGTC_1554 st069299 38.7 µM -1.27540800207183 0.100541831634368 no 3046 0.101082433914222 4305 24207999
SGTC_1689 st020265 53.493 µM -1.27641750864945 0.100365259755644 no 3047 0.10090398510674 4352 5758320 YPR016C TIF6
SGTC_410 α-linolenic acid 100 µM -1.28033934041956 0.0996814429815241 no 3048 0.100212908772403 4380 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1054 3429-0080 167 µM -1.28784907450243 0.0983815456457173 no 3049 0.0988992527832114 4372 1162877
SGTC_1200 1643-0193 18.4 µM -1.28866703436523 0.098240714057512 no 3050 0.0987569338787388 4373 5403974
SGTC_3180 9109287 49.47 µM -1.29483996489477 0.0971826543699124 no 3051 0.0976877210903683 4401 18891271
SGTC_2550 chrysin dimethyl ether 71.87 µM -1.29571991231392 0.0970325121964767 no 3052 0.0975359992899132 4194 88881 An O-methylated flavonoid and antioxidant.
SGTC_1989 st071868 50.2 µM -1.2965370631854 0.0968932373042558 no 3053 0.0973952597847803 4342 16414057
SGTC_2523 spermine 47.74 µM -1.29969827326332 0.0963558239856816 no 3054 0.0968522012129993 4382 1103 A DNA binding polyamine.
SGTC_882 0843-0131 351 µM -1.3018207979873 0.0959962208695537 no 3055 0.096488826169508 4357 5425421
SGTC_1361 1608-0041 5.61 µM -1.30594986845829 0.0952994931711874 no 3056 0.0957848031342813 4339 X1361
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.30640732357639 0.0952225331618723 no 3057 0.0957070383263993 4281 6708630 An antioxidant.
SGTC_2049 5262831 67.185 µM -1.31348319263253 0.0940379464286275 no 3058 0.0945100903768411 4343 763417
SGTC_2698 st077697 67.5 µM -1.3149614737268 0.093791843226286 no 3059 0.0942614253712734 4343 3154499
SGTC_2456 5770359 74.46 µM -1.31992028392069 0.092969776441666 no 3060 0.0934308172600877 4385 3118787
SGTC_2813 7971799 71.43 µM -1.32354795590508 0.0923717666639653 no 3061 0.0928266097314232 4392 2234054
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.3268599349723 0.0918282878687456 no 3062 0.092277509904491 4416 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_468 gf-109203x 121 µM -1.32802028322872 0.0916384420172384 no 3063 0.0920857031557802 4427 2396 A protein kinase C inhibitor.
SGTC_2995 9067767 71.4286 µM -1.32902271134858 0.0914746679262728 no 3064 0.0919202385565236 4394 11673567
SGTC_1084 voriconazole 435 nM -1.32918133344408 0.0914487725542076 no 3065 0.0918940759805936 4409 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2819 7996655 46.38 µM -1.33623371904631 0.0903029407397847 no 3066 0.0907364465234196 4361 6456960
SGTC_2745 rifampicin 24.3 µM -1.33765288791924 0.0900736565203874 no 3067 0.0905048076652532 4474 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_365 0121-0052 13.6 µM -1.33796276652848 0.0900236493963594 no 3068 0.0904542872651902 4397 3101739
SGTC_1179 1021-1431 9.29 µM -1.33825319709065 0.0899767994604046 no 3069 0.0904069565476996 4412 2840958
SGTC_1157 4092-0394 27.6 µM -1.3387818537954 0.0898915672970119 no 3070 0.0903208499391428 4446 3659885
SGTC_888 0916-0002 6.97 µM -1.33957963231107 0.0897630598533247 no 3071 0.0901910246046519 4429 2802138 YIL048W NEO1
SGTC_263 alizarin 107.927 µM -1.33961906627739 0.089756711310657 no 3072 0.0901846109722178 4434 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_428 3448-4153 16.5 µM -1.34131466574346 0.0894840494493229 no 3073 0.0899091550903376 4351 3834874
SGTC_152 4469-0003 551.229 µM -1.34477471685245 0.0889295658667748 no 3074 0.0893489987154308 4377 697280
SGTC_3229 9132204 49.47 µM -1.34726458716488 0.0885321420632788 no 3075 0.0889475165432238 4481 17682924
SGTC_1041 0206-0046 107 µM -1.35681506294186 0.0870199982390755 no 3076 0.0874199900712422 4401 50494
SGTC_2238 6671620 73.2395 µM -1.35694780411461 0.0869991178780295 no 3077 0.0873988979616463 4317 729941
SGTC_1096 rimcazole 32.2 µM -1.35723857529353 0.0869533922671647 no 3078 0.0873527087092866 4328 18528119 A dopamine reuptake inhibitor.
SGTC_2708 st078559 56 µM -1.36132846083581 0.086312132779732 no 3079 0.0867049563380214 4363 17250902
SGTC_466 geldanamycin 89.2 µM -1.3620228819146 0.0862036055519596 no 3080 0.0865953319700576 4419 5288382 HSP90 inhibitor.
SGTC_3190 9110366 49.47 µM -1.3624577589935 0.0861356930147365 no 3081 0.0865267331357408 4418 17123768
SGTC_2869 9037858 32.47 µM -1.36502325784375 0.0857358664586872 no 3082 0.0861228700848064 4377 27187042
SGTC_2257 7960413 200 µM -1.36709748653028 0.0854136201603651 no 3083 0.08579737550876 4452 2974689 YIL048W NEO1
SGTC_884 0851-0618 334 µM -1.36774175317659 0.085313713600699 no 3084 0.0856964627911707 4423 9642473
SGTC_158 k038-0087 26.446 µM -1.36993983620269 0.0849735152477201 no 3085 0.0853528415561369 4327 X158
SGTC_1587 estradiol valerate 56.1 µM -1.37316978089657 0.0844754615770188 no 3086 0.0848497858826598 4457 13791 A steroid.
SGTC_863 0466-0191 129 µM -1.37407973587051 0.084335543787161 no 3087 0.0847084648502324 4465 765160 YPR165W RHO1
SGTC_3230 9131665 49.47 µM -1.37996581290188 0.0834346784662361 no 3088 0.08379858558435 4435 15943720
SGTC_1174 0739-0097 51.1 µM -1.38468254461129 0.0827180169679708 no 3089 0.0830747794054758 4456 728447
SGTC_3336 9143619 71.43 µM -1.3855144835924 0.082592093960082 no 3090 0.0829476034448158 4431 45595730
SGTC_2101 5377231 179.231 µM -1.38554228277714 0.0825878887439164 no 3091 0.082943356398695 4452 2844213
SGTC_1484 3473-2379 286 µM -1.38616396986593 0.082493887486644 no 3092 0.0828484203084248 4547 671917
SGTC_1828 st055811 49 µM -1.39141386797534 0.0817032941932082 no 3093 0.0820499808462457 4440 5877589
SGTC_1932 st074806 40.9 µM -1.39719031755548 0.0808400211130244 no 3094 0.0811781737933192 4470 17251235
SGTC_1013 4112-3890 241 µM -1.40180499239973 0.080155334188625 no 3095 0.0804867436234944 4400 705171
SGTC_3109 9122853 49.47 µM -1.4021934014078 0.08009790591231 no 3096 0.0804287507850566 4462 1234709
SGTC_776 4476-4378 112 µM -1.40651094614785 0.0794616276984699 no 3097 0.0797862282562904 4493 2892008
SGTC_538 2922-0838 53.3 µM -1.40858325540724 0.0791575926508078 no 3098 0.0794792164908956 4458 777039
SGTC_559 1550-0661 158 µM -1.41026402354982 0.0789116494313386 no 3099 0.0792308686666254 4474 5830875
SGTC_1213 1315-0166 115 µM -1.41409542425498 0.0783531730401383 no 3100 0.0786669432383942 4443 768401
SGTC_2229 7354935 190 µM -1.41548856722515 0.0781508490653416 no 3101 0.0784626490703393 4403 318112
SGTC_2096 5468907 200 µM -1.4157495105493 0.078112996778752 no 3102 0.0784244284154683 4438 759785
SGTC_1009 4106-0057 9.87 µM -1.41997950514691 0.0775013346546482 no 3103 0.0778068238854177 4444 2928005
SGTC_1302 1159-0335 255 µM -1.42677812696327 0.0765258764904151 no 3104 0.0768219289092358 4458 649284
SGTC_1307 1187-1599 12.2 µM -1.42841919504674 0.0762918232113823 no 3105 0.0765856187457853 4454 1538471
SGTC_1338 1486-1223 76 µM -1.42930734902501 0.0761653798444394 no 3106 0.0764579573385769 4459 3444526
SGTC_404 fumagillin 50 µM -1.43229658573562 0.0757409844389991 no 3107 0.0760294799041742 4457 12015870 A methionine aminopeptidase binder.
SGTC_1685 st024049 53.0905 µM -1.43298778979447 0.0756431079788717 no 3108 0.0759306633880223 4472 1941139
SGTC_1021 4476-0760 85.3 µM -1.43363206423895 0.0755519636813545 no 3109 0.075838644155631 4478 746768
SGTC_1612 st002233 45.4 µM -1.43498866344067 0.0753603217739059 no 3110 0.0756451640492024 4469 1035021
SGTC_45 0kpi-0036 14.9 µM -1.4358562208971 0.075237959426327 no 3111 0.0755216290576758 4435 2795021
SGTC_3133 9127736 49.47 µM -1.43679028832549 0.075106385752423 no 3112 0.0753887953685126 4470 27243420
SGTC_2275 7947463 200 µM -1.43787670806108 0.0749535723842823 no 3113 0.0752345197629547 4408 1225414
SGTC_1802 st050112 57.9 µM -1.44027194255827 0.0746175020046974 no 3114 0.0748952380811566 4469 4662563
SGTC_87 0100-0052 35.5 µM -1.441749880734 0.0744107100425742 no 3115 0.0746864732075555 4476 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2519 cryptotanshinone 88.04 µM -1.44345584945102 0.0741725565737437 no 3116 0.0744460505432824 4452 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1935 st074532 41.6 µM -1.44901241751257 0.07340089437513 no 3117 0.0736670574121987 4427 2829742
SGTC_725 1497-0963 19 µM -1.45036625701843 0.0732138149591031 no 3118 0.0734782057451022 4545 3549977
SGTC_1274 0865-0114 173 µM -1.45080917214452 0.0731526902875913 no 3119 0.073416502453393 4459 870624
SGTC_977 1348-1378 135 µM -1.45184122916948 0.0730104123698071 no 3120 0.0732728785216795 4451 X977
SGTC_3264 9137442 49.47 µM -1.45225589214278 0.0729533071987612 no 3121 0.0732152334335648 4439 17015726
SGTC_1402 3909-7673 35.9 µM -1.45385053950713 0.0727340193797835 no 3122 0.0729938740251147 4492 5328014
SGTC_409 arachidonic acid 100 µM -1.45425105494939 0.0726790219113328 no 3123 0.0729383574327826 4466 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_283 0987-0079 11.7 µM -1.45670539092491 0.0723426958180786 no 3124 0.0725988605232294 4474 411556
SGTC_3127 9126946 49.47 µM -1.45694130088144 0.0723104311933445 no 3125 0.0725662920568619 4421 27243249
SGTC_1266 0828-0227 32.9 µM -1.46122528937636 0.0717264407218845 no 3126 0.0719768124974182 4446 3913820
SGTC_1012 4112-3522 18 µM -1.46142290705846 0.071699589160826 no 3127 0.0719497090298495 4477 3112398
SGTC_1153 4055-0057 267 µM -1.4619979823318 0.0716214939254332 no 3128 0.0718708813885884 4515 882706
SGTC_1508 1080-0625 72.9 µM -1.46528786026248 0.0711759824333489 no 3129 0.0714211985993843 4402 767111
SGTC_967 1306-0166 352 µM -1.46546170087692 0.0711525004588293 no 3130 0.0713974970904333 4476 4437607
SGTC_1451 4152-0210 104 µM -1.46634808618977 0.0710328621309604 no 3131 0.0712767407654005 4511 659563
SGTC_2378 9074213 121.43 µM -1.46696941745279 0.0709490911633991 no 3132 0.0711921874816398 4442 657714
SGTC_2704 st078022 71.1 µM -1.46842129877225 0.07075363716674 no 3133 0.0709949098188473 4500 54697681
SGTC_1964 st076914 61 µM -1.46879929536689 0.0707028187556181 no 3134 0.0709436176258123 4516 24208661
SGTC_3342 9147791 14.508 µM -1.46892687103028 0.0706856736303734 no 3135 0.0709263126908983 4431 1838168
SGTC_1447 4239-0816 81.9 µM -1.47053416255578 0.0704699404069122 no 3136 0.0707085701293297 4488 1341554
SGTC_364 0083-0097 67.7 µM -1.47341937443292 0.0700839529741248 no 3137 0.070318994629177 4501 5207356
SGTC_2437 5741531 144.16 µM -1.47656978533647 0.0696643466068811 no 3138 0.0698954979737935 4491 2262990
SGTC_3011 9081274 71.4286 µM -1.47717168748454 0.0695843991685253 no 3139 0.0698148105450115 4480 6625322
SGTC_862 0452-0056 10.2 µM -1.48118229859525 0.069053493582635 no 3140 0.0692790009418504 4438 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_3096 9117468 49.47 µM -1.48515176924236 0.0685311132529426 no 3141 0.0687518125018603 4447 41316311
SGTC_2867 9039098 71.43 µM -1.48770120728765 0.0681972195134946 no 3142 0.0684148545396684 4464 6463460
SGTC_2361 9034121 116 µM -1.49272161698655 0.0675433810105296 no 3143 0.0677550362060484 4511 6496917
SGTC_227 fluconazole 33.516 µM -1.49466617743289 0.0672914344703612 no 3144 0.0675007927820207 4493 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_480 am 92016 50 µM -1.49541659383341 0.0671944014479852 no 3145 0.0674028762524608 4514 2129 K+ channel blocker.
SGTC_1272 0839-0021 27 µM -1.49625253316019 0.0670864372558772 no 3146 0.0672939297436427 4523 5027250
SGTC_2605 digitonin 300 nM -1.49636899862334 0.0670714060284125 no 3147 0.0672787618142757 4499 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1708 st033234 31.827 µM -1.50030820000584 0.0665645384281316 no 3148 0.0667672931712168 4565 674664
SGTC_1313 1220-0047 237 µM -1.50476757057673 0.0659943229980376 no 3149 0.066191921988367 4488 3528706
SGTC_1445 4239-0156 97.7 µM -1.50673164667835 0.0657443822162136 no 3150 0.0659397281567355 4535 4008346
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.5080337169784 0.065579090643709 no 3151 0.0657729489041636 4519 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2151 5563267 85.4165 µM -1.51560655894772 0.0646241340036586 no 3152 0.0648094337892918 4557 5310824
SGTC_2799 7812892 81.82 µM -1.51586347268248 0.0645919269034158 no 3153 0.0647769391374391 4522 20205235
SGTC_699 0375-0592 111 µM -1.51634708613843 0.0645313342037051 no 3154 0.0647158056487016 4575 762578
SGTC_108 0509-0257 621.132 µM -1.51650632786366 0.0645113922208889 no 3155 0.064695685739718 4465 536624
SGTC_1924 st058459 75.1 µM -1.51699586131059 0.0644501174921807 no 3156 0.0646338644791944 4457 688683
SGTC_2030 5175110 200 µM -1.52120968098294 0.0639245434317731 no 3157 0.0641036134043199 4500 2831986
SGTC_1900 st060200 72.8 µM -1.52153154132002 0.0638845364055398 no 3158 0.0640632511552199 4491 688945
SGTC_2525 harmine 47.85 µM -1.52460321466758 0.0635037085099451 no 3159 0.0636790475541813 4506 5280953 A monoamine oxidase inhibitor
SGTC_1977 st070720 65.3 µM -1.52638300892418 0.0632838583589039 no 3160 0.0634572533208182 4531 682188
SGTC_1267 0828-0272 9.49 µM -1.5310858911574 0.062705783404765 no 3161 0.0628740831509016 4561 745334
SGTC_3044 9093193 49.47 µM -1.53587220227382 0.0621216873875938 no 3162 0.0622848635002669 4513 25236277
SGTC_1102 cgs 12066b 26.1 µM -1.5388346350211 0.0617622999486318 no 3163 0.0619223360188238 4528 6438352 A 5-HT1B full agonist.
SGTC_651 3253-0966 34.4 µM -1.54780891077865 0.0606834869614896 no 3164 0.0608341552395109 4544 781462
SGTC_2594 a-mangostin 100 µM -1.55249543910239 0.0601259995260877 no 3165 0.0602718615875379 4516 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_127 0180-0333 59.125 µM -1.55637436172206 0.0596676207540082 no 3166 0.0598095490532168 4429 771601
SGTC_140 0062-0056 502.533 µM -1.55661736425746 0.059638996132996 no 3167 0.0597806793226335 4435 3758964
SGTC_1378 2093-0007 380 nM -1.55977392128086 0.0592681447022818 no 3168 0.0594066581556245 4544 3618014
SGTC_1343 1487-0095 224 µM -1.56166040138245 0.0590473743651404 no 3169 0.0591840060158016 4515 4560101 YGL055W OLE1
SGTC_2073 5212005 126 µM -1.56334609092413 0.0588506483026128 no 3170 0.0589856063673437 4441 691789
SGTC_2463 5473429 200 µM -1.5636427281408 0.0588160829455144 no 3171 0.0589507472755345 4528 5399405
SGTC_2805 7950783 58.44 µM -1.56680370381178 0.0584487420889859 no 3172 0.0585802907017592 4529 1178958 YDL195W SEC31
SGTC_1550 gossypolone 36.6 µM -1.57306219978685 0.0577267515486121 no 3173 0.05785220825248 4561 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3095 9117207 49.47 µM -1.57459540547296 0.0575509521916959 no 3174 0.057674932028493 4537 17015229
SGTC_872 0588-0139 234 µM -1.57948999091691 0.0569925494766444 no 3175 0.0571118552589024 4491 2047100
SGTC_224 benfluorex 43.875 µM -1.58720930193338 0.0561205649511425 no 3176 0.056232624357696 4546 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1767 st044992 70.3 µM -1.58814058123683 0.0560160813298224 no 3177 0.0561272768062734 4569 9600693
SGTC_2943 9068529 45.32 µM -1.59145276225226 0.0556457184228686 no 3178 0.0557538591165595 4495 3270634
SGTC_1691 st019933 84.6 µM -1.59232347809135 0.0555486778514265 no 3179 0.0556560201138195 4536 6176082
SGTC_1062 mesoridazine 14.2 µM -1.59234140108181 0.0555466817528329 no 3180 0.0556540076003166 4587 4078 A neuroleptic.
SGTC_1059 3448-6867 171 µM -1.59312902619025 0.055459019182732 no 3181 0.0555656244802372 4508 3934407
SGTC_1424 4048-1941 275 µM -1.61252885409727 0.0533341045826439 no 3182 0.0534234531376668 4618 X1424
SGTC_744 1594-0068 283 µM -1.6182682834145 0.0527179744425595 no 3183 0.0528023963829406 4544 668392
SGTC_188 3229-0966 278.469 µM -1.6265202271731 0.0518420374790108 no 3184 0.0519195169960907 4603 5722370
SGTC_199 4063-0024 41.6 µM -1.62771673261576 0.0517159951428131 no 3185 0.0517924817282522 4601 306215
SGTC_1045 1348-1485 165 µM -1.62811400132525 0.0516741999508189 no 3186 0.051750357622565 4534 6810614
SGTC_1077 5-fluorocytosine 377 nM -1.62879112613622 0.0516030240125985 no 3187 0.0516786219437011 4587 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1735 st034310 56.75 µM -1.63530892265087 0.0509218856911371 no 3188 0.0509921520219671 4561 871153
SGTC_609 0986-0026 86.3 µM -1.63558606052121 0.0508930829679951 no 3189 0.0509631248506733 4555 2848610
SGTC_2933 9026794 32.47 µM -1.63895092947407 0.0505444085157629 no 3190 0.0506117398485599 4504 17586027
SGTC_1700 st030840 7.9285 µM -1.63923016617569 0.0505155591725617 no 3191 0.0505826667768399 4603 5499307
SGTC_1057 3448-5381 134 µM -1.64813976907224 0.0496019307774992 no 3192 0.0496619965520731 4549 5497911
SGTC_292 k038-0015 474 µM -1.65419962895605 0.048988096518171 no 3193 0.0490434791186216 4557 46368540
SGTC_2903 5923464 63.88 µM -1.65467835392273 0.0489398638162615 no 3194 0.0489948800899083 4585 2876576
SGTC_2208 7283366 200 µM -1.6635581310215 0.0480520651616433 no 3195 0.0481003824289917 4566 898663
SGTC_3123 9126162 49.47 µM -1.67094524285504 0.0473233651095463 no 3196 0.0473662469878972 4570 25239884
SGTC_988 1497-1057 103 µM -1.67788907958727 0.046646492198507 no 3197 0.0466843773999571 4569 3533044
SGTC_1281 0884-0031 11.8 µM -1.67910995255109 0.0465282905907614 no 3198 0.0465653084552176 4586 1548255
SGTC_2742 clothiapine 36.27 µM -1.69278408741548 0.0452207569584685 no 3199 0.0452482863253212 4629 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_96 0929-0093 37.281 µM -1.69887424687618 0.0446480047132962 no 3200 0.0446714401552008 4590 6991579
SGTC_1047 2043-3044 82 µM -1.69952620797496 0.0445870384594328 no 3201 0.0446100404097445 4552 669592
SGTC_726 3448-4391 34.2 µM -1.70037259105367 0.044507991452855 no 3202 0.0445304320100107 4645 1356692
SGTC_196 k015-0023 18.111 µM -1.70225273515754 0.0443328014309398 no 3203 0.0443540004461719 4544 5211998
SGTC_185 k048-0037 25.491 µM -1.70264989917289 0.0442958652586018 no 3204 0.04431680298288 4634 6827589
SGTC_7 0192-1582 4.227 µM -1.7090922503133 0.0437001848599728 no 3205 0.0437169314356423 4637 252616
SGTC_1295 1013-0063 9.78 µM -1.71153752942827 0.043475785715208 no 3206 0.0434909646577417 4597 6826038
SGTC_1723 st034307 2.5525 µM -1.71302949995176 0.0433393276041209 no 3207 0.0433535562935307 4583 867466
SGTC_724 3910-0327 137 µM -1.7173793082487 0.0429434598432591 no 3208 0.0429549449055705 4606 2885483
SGTC_1006 4099-6547 255 µM -1.7177491928892 0.0429099325766564 no 3209 0.0429211861713664 4603 3146833
SGTC_3226 9131256 49.47 µM -1.71859465786341 0.0428333769512609 no 3210 0.0428441025454242 4614 17178073
SGTC_2360 9040895 200 µM -1.71907769811587 0.042789687931787 no 3211 0.0428001125350581 4605 4914414
SGTC_2795 7780010 54.55 µM -1.7254260850613 0.0422188428337153 no 3212 0.0422253568731457 4561 953673
SGTC_2608 thymoquinone 42.66 µM -1.72595527755683 0.0421715375685055 no 3213 0.0421777294087741 4560 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2783 7738165 71.43 µM -1.72615847052106 0.0421533852626804 no 3214 0.0421594535427269 4577 17201110
SGTC_2744 captopril 92.04 µM -1.72662451682656 0.0421117747558421 no 3215 0.0421175599587895 4650 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_754 3474-0146 171 µM -1.73016931024901 0.0417963681473987 no 3216 0.0418000148998205 4579 24762078
SGTC_675 1309-0189 238 µM -1.73473814772815 0.0413926694944646 no 3217 0.0413935980662548 4610 4246530
SGTC_53 0973-0023 39.979 µM -1.73809757014804 0.0410978544240196 no 3218 0.0410968114955508 4532 674768
SGTC_2444 5485484 36.41 µM -1.74357961087004 0.0406204216589008 no 3219 0.0406162105861861 4635 6790631
SGTC_1408 3909-7976 48.8 µM -1.74741294541607 0.0402892573237231 no 3220 0.0402828667716284 4649 24152374
SGTC_1760 st045453 10.4495 µM -1.75159167454934 0.0399307556433093 no 3221 0.0399220225868601 4614 3323419 YIL048W NEO1
SGTC_960 1222-0186 7.7 µM -1.75435966740413 0.0396947145574942 no 3222 0.0396844488580453 4599 3126296
SGTC_3135 9127742 49.47 µM -1.76047793492443 0.0391770027374047 no 3223 0.0391634027414082 4646 3643468
SGTC_1256 0570-0116 285 µM -1.76088257577976 0.0391429577520365 no 3224 0.0391291398153365 4599 410638
SGTC_671 0560-0003 407 µM -1.76184172928926 0.0390623543138138 no 3225 0.0390480210462504 4586 3238678
SGTC_3000 9075062 71.4286 µM -1.76593197643571 0.0387201417332582 no 3226 0.0387036308872143 4597 17057871
SGTC_2947 9072639 7.68 µM -1.77553296852401 0.0379264594333804 no 3227 0.0379049634472311 4560 16488146
SGTC_806 3966-4455 5.86 µM -1.77745352306831 0.0377692977751296 no 3228 0.0377468256289488 4603 714982
SGTC_1197 1601-0112 267 µM -1.78212909361113 0.0373889107419637 no 3229 0.0373640911944565 4587 7350313
SGTC_287 k060-0039 29.6 µM -1.78950341635875 0.0367953277887638 no 3230 0.0367668888896967 4655 5861974
SGTC_3182 9108849 49.47 µM -1.79581835583102 0.036293163722083 no 3231 0.0362617052184053 4617 17133045
SGTC_1851 st056236 18.9 µM -1.81604954427701 0.0347220335144395 no 3232 0.0346813862394724 4613 5393171
SGTC_2676 harmalol 100 µM -1.81926367512243 0.0344776465370407 no 3233 0.0344356062117522 4615 5459187 A monoamine oxidase inhibitor
SGTC_1151 3909-8316 15.3 µM -1.82190504231746 0.0342778692128689 no 3234 0.0342346975521338 4659 800431
SGTC_723 4182-0001 115 µM -1.82774728956237 0.0338393748053501 no 3235 0.033793743660231 4632 744821 YLR208W SEC13
SGTC_2294 7971431 200 µM -1.8291486946636 0.0337348803318948 no 3236 0.033688667934817 4619 5741572
SGTC_2226 7298446 200 µM -1.82967602005799 0.0336956296144884 no 3237 0.0336491993706177 4650 3283010
SGTC_1927 st060202 13.8 µM -1.83102365954413 0.0335954906993771 no 3238 0.0335485058767281 4584 688887
SGTC_2515 chrysin 20.77 µM -1.83102697655077 0.0335952445254087 no 3239 0.0335482583415635 4646 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1254 0550-0035 264 µM -1.83499059186714 0.0333021411237913 no 3240 0.0332535417298057 4612 15121435
SGTC_1001 4048-4355 44.4 µM -1.84142688386425 0.0328306757067556 no 3241 0.0327795130775873 4625 21824233
SGTC_1610 st001799 48.1 µM -1.8419358626118 0.0327936284063864 no 3242 0.0327422660325177 4606 621897
SGTC_318 1488-0629 67.2 µM -1.84451784103096 0.0326062231170656 no 3243 0.032553854093201 4691 3662576
SGTC_1193 1488-0126 41.5 µM -1.84544497724039 0.0325391455639698 no 3244 0.0324864177665794 4628 1384710
SGTC_1641 st009299 47.1 µM -1.85115983934717 0.032128188788667 no 3245 0.0320732807462808 4591 4046054
SGTC_2763 lisinopril 49.32 µM -1.85649290740144 0.0317485610744987 no 3246 0.0316916665218688 4565 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2079 5212404 121 µM -1.87184796992109 0.0306761794638724 no 3247 0.0306138197777285 4610 758462
SGTC_2885 9057732 51.95 µM -1.87571422488749 0.0304109430365512 no 3248 0.0303472657806371 4641 6471414
SGTC_1969 st069479 40.1 µM -1.87843961642861 0.0302251172471483 no 3249 0.0301605251324107 4646 3895485
SGTC_739 1486-1183 203 µM -1.88017702519676 0.0301071471964195 no 3250 0.0300419778401922 4653 4346692
SGTC_355 1311-2252 105 µM -1.88043349399234 0.0300897653430019 no 3251 0.0300245111693507 4614 5338538
SGTC_2939 9044578 71.43 µM -1.88512074875325 0.029773555278985 no 3252 0.0297067686703188 4598 2653634
SGTC_1757 st041620 31.8375 µM -1.89844481744225 0.0288897171400897 no 3253 0.02881875525707 4636 5289815
SGTC_2979 9012552 45.46 µM -1.90266751532916 0.0286142018344649 no 3254 0.0285419716361092 4660 17100905
SGTC_1686 st019653 115.5 µM -1.9037035125506 0.0285469417452534 no 3255 0.0284744043606747 4660 97252
SGTC_670 4204-0025 119 µM -1.90688766660949 0.0283410395768846 no 3256 0.0282675678108068 4665 719039
SGTC_1030 k029-0042 36.7 µM -1.91001602604569 0.0281399504670498 no 3257 0.0280655749561726 4648 6080581
SGTC_2210 7115885 190.385 µM -1.91671700891224 0.0277132108454206 no 3258 0.0276369466083436 4726 2927039
SGTC_802 4112-3352 742 µM -1.91738985465154 0.0276706614418181 no 3259 0.0275942110775568 4689 704594
SGTC_1682 st012968 530 nM -1.92241304051282 0.0273547228081629 no 3260 0.0272769030012025 4623 24207270
SGTC_383 2324-0395 7.37 µM -1.93193626199449 0.0267640065556264 no 3261 0.0266836866847471 4643 3146421
SGTC_2932 9016711 44.54 µM -1.9400697616959 0.0262679632779915 no 3262 0.0261856061460589 4636 7117328
SGTC_2115 tiliquinol 12.7705 µM -1.94292210012623 0.026095836170557 no 3263 0.026012785622582 4643 71208 A bioactive hydroxyquinoline.
SGTC_2212 7123476 200 µM -1.94722991084115 0.0258376659697287 no 3264 0.0257535886240635 4715 1085715
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.94946202680308 0.025704736477996 no 3265 0.0256201366969376 4664 641818 YHR062C RPP1
SGTC_3066 9117245 49.47 µM -1.9567274860341 0.0252760136618296 no 3266 0.025189758272298 4692 17176980
SGTC_3026 9090633 49.47 µM -1.95928154824608 0.0251267329538788 no 3267 0.0250399117197633 4677 25236842
SGTC_1616 st002734 56.1 µM -1.96553307421685 0.0247644569985856 no 3268 0.0246762857622411 4670 4026101
SGTC_2884 9058502 51.95 µM -1.97236624800789 0.024373496699411 no 3269 0.0242839059780142 4661 6471554
SGTC_113 0099-0221 2.5 µM -1.97495841563513 0.0242265477241492 no 3270 0.0241364336570385 4637 89219
SGTC_770 0389-1121 67.2 µM -1.98229483959896 0.0238146763893588 no 3271 0.0237231256301888 4707 6753108
SGTC_2871 9038510 12.99 µM -1.98342626878103 0.0237516841823432 no 3272 0.0236599176532894 4636 4945164
SGTC_3041 9091929 49.47 µM -1.98957280470011 0.0234119191738184 no 3273 0.0233190072019582 4656 25236887
SGTC_2986 9022445 71.43 µM -1.99130644851912 0.0233168304227064 no 3274 0.0232236034782448 4663 6459286
SGTC_2019 4016004 108 µM -2.00004414891081 0.022842509353014 no 3275 0.022747748411047 4667 45595336
SGTC_654 1124-0271 80.9 µM -2.01409181896152 0.0220969911478954 no 3276 0.0219999471501849 4695 5403748
SGTC_731 3966-0296 387 µM -2.03374387778491 0.0210885857587648 no 3277 0.0209887128456526 4706 660956
SGTC_673 1082-0474 110 µM -2.0415568312655 0.0206986392549193 no 3278 0.0205977555491518 4675 3098046
SGTC_2130 NSC 7 2.4545 µM -2.05383810025015 0.0200980283506503 no 3279 0.019995682000429 4701 21448
SGTC_1403 3909-7815 62.9 µM -2.05751307754308 0.0199212038359412 no 3280 0.0198184491421447 4714 6615483
SGTC_2791 5663188 71.43 µM -2.06459130239664 0.0195843473995019 no 3281 0.0194808434542979 4666 54690634
SGTC_1853 st056710 91.2 µM -2.08065185636452 0.0188379186725831 no 3282 0.0187328918600687 4712 269167
SGTC_302 1094-0063 18.9 µM -2.09008269617689 0.0184109959204219 no 3283 0.0183051858926658 4715 5440289
SGTC_2107 5363541 170.161 µM -2.1018707871725 0.0178889758113466 no 3284 0.0177822980845937 4666 244052
SGTC_1467 k284-1082 293 µM -2.10323043028214 0.0178295857640528 no 3285 0.0177228157289921 4676 3334705
SGTC_2396 5342950 42.78 µM -2.10541066534954 0.0177347028552885 no 3286 0.0176277881037978 4674 1886677
SGTC_1923 st058458 19.1 µM -2.10908537598096 0.0175757559864685 no 3287 0.0174686064604642 4687 3534982
SGTC_619 1652-1634 108 µM -2.1104225759602 0.0175182189266591 no 3288 0.0174109867938686 4677 5400454
SGTC_1886 st057356 49.9 µM -2.11653308663416 0.0172573377826441 no 3289 0.0171497471355034 4705 24207747
SGTC_1962 st076595 64.5 µM -2.11886953231035 0.0171584668128903 no 3290 0.0170507472243074 4679 279619
SGTC_1806 st050005 60.3 µM -2.1238988083702 0.0169472851073903 no 3291 0.0168393030346673 4747 5194765
SGTC_1374 2889-5571 141 µM -2.14919685159079 0.0159184004239395 no 3292 0.0158093993814741 4709 2853281
SGTC_2522 biochanin a 4.94 µM -2.15730616692716 0.0156001340382518 no 3293 0.0154909084120318 4703 5280373 A possible chelator.
SGTC_3111 9122088 49.47 µM -2.15802352254721 0.0155722446956352 no 3294 0.0154630014984981 4687 16876704
SGTC_54 0159-0055 9 µM -2.17850677183239 0.0147937569050989 no 3295 0.0146841643126721 4700 3319099
SGTC_2118 5526350 200 µM -2.18229584782193 0.0146534785119932 no 3296 0.01454385263142 4720 743594
SGTC_325 2810-4341 181 µM -2.19335158518957 0.0142506981835453 no 3297 0.0141410288356808 4725 774970
SGTC_280 3448-3607 3.04 µM -2.21228809608357 0.013582947995369 no 3298 0.0134733825433414 4716 626179
SGTC_1609 st001574 46.4 µM -2.21335939851487 0.013545991846789 no 3299 0.0134364387522604 4725 3960012
SGTC_1807 st050092 58.9 µM -2.21940243913975 0.0133391497427248 no 3300 0.0132296789363254 4725 5008496
SGTC_2393 9031399 185.94 µM -2.2235637535199 0.0131983066539688 no 3301 0.0130889047638956 4698 1526623 YDL150W RPC53
SGTC_391 gliotoxin 8.33 µM -2.23024201099977 0.0129749611595084 no 3302 0.0128656903120935 4738 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1208 2323-2347 50.3 µM -2.25711287121365 0.0121090124839369 no 3303 0.0120005114088127 4734 5412760
SGTC_564 3555-0129 330 µM -2.25862135085724 0.0120619211389529 no 3304 0.011953474270158 4715 563260
SGTC_891 0929-0073 133 µM -2.27294862923948 0.0116225149725618 no 3305 0.0115146379090139 4742 5603632
SGTC_1005 4092-0690 4.4 µM -2.28621544406279 0.0112280931183346 no 3306 0.0111208288455748 4717 1529343
SGTC_2790 5423970 71.43 µM -2.30185303263046 0.0107781739723626 no 3307 0.0106717308251252 4710 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1764 st044502 93.5 µM -2.30507021342987 0.0106875822598009 no 3308 0.0105813206944336 4748 8407
SGTC_3278 9139605 49.47 µM -2.3062166423664 0.0106554609059242 no 3309 0.010549265058622 4722 7958859
SGTC_773 4358-1457 44.6 µM -2.322848936192 0.0101988190369053 no 3310 0.0100936345622661 4741 1186886
SGTC_146 3448-8650 53.125 µM -2.35847854432997 0.00927769259649785 no 3311 0.00917501026124092 4720 2891488 YIL048W NEO1
SGTC_1714 st033236 13.627 µM -2.38141378543347 0.00872402171006794 no 3312 0.00862316363571801 4732 2916566
SGTC_303 1348-1668 34.2 µM -2.43183338347146 0.00760767306055813 no 3313 0.00751130805111508 4771 5380509
SGTC_163 TUB2.036 7.546 µM -2.44137321551139 0.00741121420939903 no 3314 0.00731576246548646 4710 15992207 YJR013W GPI14
SGTC_3314 9135860 59.4275 µM -2.46001799200997 0.00704012076446524 no 3315 0.00694650253800731 4745 25252478
SGTC_1087 pterostilbene 9.05 µM -2.47080215408778 0.00683304994275268 no 3316 0.0067405189444221 4764 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1201 1889-3372 45.9 µM -2.47723534162459 0.00671210216159171 no 3317 0.0066202282414458 4721 5392199
SGTC_1089 terbinafine 2.25 µM -2.48916048326615 0.00649289798076184 no 3318 0.00640225760998006 4769 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_738 1315-0003 72.4 µM -2.49839542923411 0.0063275194849244 no 3319 0.00623784719921484 4760 6251474
SGTC_1903 st060211 78.3 µM -2.49882302625949 0.006319953259392 no 3320 0.00623032605191488 4760 688960
SGTC_1430 4049-0248 69.1 µM -2.50135163741065 0.00627537360316185 no 3321 0.00618601340981511 4770 22774488
SGTC_2622 2-methoxyxanthone 59.94 µM -2.50492044973642 0.00621292892452237 no 3322 0.00612394684889235 4744 71034 A hepatoprotective.
SGTC_667 1498-1044 59 µM -2.54802464378883 0.00550105707195462 no 3323 0.00541674088909087 4770 6739982
SGTC_285 1486-1325 46 µM -2.56406207497228 0.0052552955947438 no 3324 0.0051727520080754 4779 22310230
SGTC_1528 arabinosylhypoxanthine 74.6 µM -2.58035175540606 0.00501571524270546 no 3325 0.00493498614105804 4780 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1483 3453-0561 55.9 µM -2.58058083148633 0.00501241662589374 no 3326 0.00493171312300902 4781 4546991
SGTC_1826 st055655 41.6 µM -2.58533475036702 0.00494439653065297 no 3327 0.00486422471046786 4760 676168
SGTC_3013 9080133 71.4286 µM -2.65331988662975 0.00405773889684653 no 3328 0.00398521477023106 4784 17050193
SGTC_2909 7941780 10.49 µM -2.68082186409263 0.00374151898936821 no 3329 0.00367207996905859 4762 1243215
SGTC_663 1486-0733 13.9 µM -2.69236174684288 0.00361554846178194 no 3330 0.00354739721021846 4779 722445 YPR165W RHO1
SGTC_281 1672-3440 14.9 µM -2.71265957847048 0.00340318128342687 no 3331 0.00333728177403362 4790 6833000
SGTC_1901 st060216 58.6 µM -2.71566198576961 0.00337273861526791 no 3332 0.00330717051483872 4776 688792
SGTC_2061 5245884 80.95 µM -2.72176116752741 0.00331164896828216 no 3333 0.00324675264266931 4772 573863
SGTC_1762 st045503 25.4615 µM -2.72441364121515 0.00328539350922754 no 3334 0.00322078869903799 4766 4645554
SGTC_3292 9120825 59.784 µM -2.73250949736278 0.00320641050545153 no 3335 0.00314269296591781 4769 24824900
SGTC_503 tyrphostin 8 294 µM -2.74266509344116 0.00310975044871445 no 3336 0.00304714031200792 4780 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_3059 1327-0034 3 µM -2.77002603751252 0.00286225167890209 no 3337 0.00280259058282552 4708 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2724 maprotiline 69.64 µM -2.82513059231855 0.00241696927080057 no 3338 0.0023630674677021 4765 4011 A tricyclic antidepressant.
SGTC_1454 4239-0054 42.6 µM -2.93882931339824 0.0016902351148922 no 3339 0.00164727227404587 4798 1340767
SGTC_1038 k292-0204 154 µM -2.9639624041228 0.0015592661843773 no 3340 0.00151852694614801 4753 4454212
SGTC_72 0744-0168 198.391 µM -2.98458254375891 0.00145879848955135 no 3341 0.0014198278665055 4755 677577
SGTC_1897 st060201 15 µM -3.02762436662972 0.00126786459371249 no 3342 0.00123242133048438 4792 611878
SGTC_143 4032-1194 15.74 µM -3.13317396963994 0.000892375918311134 yes 3343 0.000864634567426287 4796 1806963
SGTC_2627 acetyl isogambogic acid 100 µM -3.17607293533694 0.000771407596518981 yes 3344 0.000746417067166448 4774 6857789 A caspase activator and apoptosis inducer.
SGTC_2131 toluylene red 5.2905 µM -3.19868080451679 0.000713916124492341 yes 3345 0.000690289663095784 4775 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1871 st057448 67.3 µM -3.43330481558619 0.000310777218187323 yes 3346 0.000298135671736163 4800 691747
SGTC_2347 9049783 174.81 µM -3.52467790885605 0.000221708841420195 yes 3347 0.000211998995345995 4794 6467988 YPL169C MEX67
SGTC_2617 dihydrotanshinone i 20.83 µM -3.62515590345231 0.000151567280045916 yes 3348 0.000144393590884711 4782 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_964 1287-0107 19.4 µM -3.68344567280761 0.000121033984128945 yes 3349 0.000115051170952547 4795 51516812 YPR165W RHO1
SGTC_294 k038-0071 157 µM -3.8478998392922 6.30712811509302e-05 yes 3350 5.95673694399844e-05 4809 24152826
SGTC_1868 st057644 42.7 µM -4.06203364641575 2.59855045616575e-05 yes 3351 2.43235316705147e-05 4808 688665
SGTC_333 3486-0131 40.1 µM -4.07500803850272 2.45921332420618e-05 yes 3352 2.3006378811591e-05 4810 6744690
SGTC_331 k048-0133 24.5 µM -4.27385077072914 1.03598145695057e-05 yes 3353 9.60628241982058e-06 4809 6813582
SGTC_329 k048-0121 21.3 µM -4.31084319396333 8.78448624987449e-06 yes 3354 8.13166027322966e-06 4807 6832902
SGTC_1904 st060225 78 µM -4.36910401005702 6.75701869131191e-06 yes 3355 6.2378670395643e-06 4805 66595
SGTC_1738 st035555 74 µM -4.92671464294788 4.65906206834156e-07 yes 3356 4.18118708852831e-07 4807 5331140