SGTCid condition conc unit YRO2|YBR054W.score YRO2|YBR054W.strain.pval YRO2|YBR054W.strain.significant YRO2|YBR054W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2604 4'-hydroxychalcone 11.32 µM 5.32843499816489 1.01830669348605e-09 yes 1 4.95313188855182e-08 10 5282362
SGTC_2483 5729050 27.16 µM 5.13256072421141 3.89550093830434e-09 yes 2 1.42913233332308e-07 9 2865180
SGTC_2919 7978188 46.38 µM 4.70165460279802 6.29663053974128e-08 yes 3 1.29030880314062e-06 10 2980291
SGTC_1475 4092-1048 11.7 µM 4.23025323337796 1.0144012954506e-06 yes 4 1.16714192638115e-05 27 2881759
SGTC_2572 astragaloside iv 100 µM 3.84054488871951 8.20105519191091e-06 yes 5 6.13807605659815e-05 29 45006101 An anti-inflammatory agent.
SGTC_1182 1222-0449 220 µM 3.82796797721436 8.74596099078689e-06 yes 6 6.46027807946743e-05 23 658318
SGTC_2703 st077852 53.4 µM 3.77584252224831 1.1394519300469e-05 yes 7 7.9733860801914e-05 29 6281836
SGTC_1836 st055642 81 µM 3.53558900382344 3.69410223856168e-05 yes 8 0.00020343357977806 32 8571
SGTC_1314 1222-0010 41.1 µM 3.51869757855556 4.00190762565651e-05 yes 9 0.000216835378967021 21 3526027
SGTC_1464 k208-0027 110 µM 3.40215875891324 6.88570213960704e-05 yes 10 0.00033427894192148 38 X1464
SGTC_1156 4092-0367 4.88 µM 3.24276161735328 0.000140818999160664 yes 11 0.000591886055037028 56 1357585
SGTC_940 3232-1287 54.8 µM 3.22173503313376 0.000154399768734063 yes 12 0.000637084546261931 69 1585493 YIL048W NEO1
SGTC_2258 7960471 200 µM 3.19031681113537 0.000176994221503674 yes 13 0.000710584535228817 33 2974708
SGTC_259 usnic acid 108.925 µM 3.05087586415614 0.000319839430950716 yes 14 0.00114087445040247 52 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1004 4084-0029 199 µM 3.00801377035449 0.000381829861201529 yes 15 0.00131480611214074 60 716894 YLR208W SEC13
SGTC_2123 5259487 200 µM 2.96685737726583 0.000451689546829294 yes 16 0.00150430242393814 59 2173474
SGTC_2287 7945887 168.79 µM 2.95979694266443 0.00046480314325582 yes 17 0.0015392093612888 38 1245853
SGTC_1693 xanthone 101.9 µM 2.91290005010978 0.000561259230962968 yes 18 0.0017904459844226 51 7020 An insecticide.
SGTC_1718 roemerine 11.9335 µM 2.90993645495214 0.000567936923840452 yes 19 0.00180751123852999 126 235224 An aporphine alkaloid with mutagenic activity.
SGTC_704 1310-0270 142 µM 2.90477368801166 0.000579745568063672 yes 20 0.00183759365803069 90 5718033
SGTC_268 camptothecin 39.6153 µM 2.8965876600793 0.000598935204016391 yes 21 0.00188622615893035 157 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1268 0828-0275 2.46 µM 2.89504626847026 0.000602613526416586 yes 22 0.00189551324817394 74 745337
SGTC_1507 4075-3230 155 µM 2.88466594656904 0.000627933327326289 yes 23 0.00195914594744372 40 659771
SGTC_1881 5652484 16 µM 2.86403705348065 0.000681191245353445 yes 24 0.00209139539583438 87 2255129
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 2.85792973896275 0.000697740117858399 yes 25 0.00213207399234878 95 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1350 1495-0454 146 µM 2.82801290937578 0.000784292576101966 yes 26 0.00234189588723501 89 1069057
SGTC_1308 1187-1617 41.4 µM 2.78780162902219 0.000916227092462748 yes 27 0.00265335137321208 117 2882570
SGTC_856 0433-0016 11.3 µM 2.77732234148068 0.000953810983941459 yes 28 0.00274043968574585 65 3911780
SGTC_2639 lactacystin 53 µM 2.75362264288583 0.00104408778658063 no 29 0.00294698412566254 92 3870 A proteasome inhibitor.
SGTC_2335 9018011 154.17 µM 2.74516132943521 0.00107817247378494 no 30 0.00302405786220646 93 6458208
SGTC_2308 7584454 197.62 µM 2.72579122765477 0.00116007525038256 no 31 0.00320737792219162 100 893577
SGTC_2313 7726885 200 µM 2.70349490454161 0.00126138214972798 no 32 0.00343072499981475 102 726423
SGTC_851 0394-0702 453 µM 2.68356064882537 0.00135874163656515 no 33 0.00364213809390555 73 762646
SGTC_1663 st014140 55.4 µM 2.67048034152895 0.00142630670141826 no 34 0.00378714033218179 99 4207120
SGTC_2426 5582046 32.21 µM 2.61502579567018 0.00174816348719475 no 35 0.00446103584362152 107 2251934
SGTC_917 harmaline 728.087 nM 2.60276514882224 0.0018277013766105 no 36 0.004623763829818 113 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_37 0566-0070 1.56 µM 2.60173305644028 0.0018345447398478 no 37 0.00463770093869698 126 1626686
SGTC_2835 9006588 71.43 µM 2.60092398733383 0.00183992561254522 no 38 0.00464865259735241 137 2345538
SGTC_722 3534-0461 190 µM 2.58965181456341 0.00191640087710411 no 39 0.00480365251228515 135 658262
SGTC_2606 farnesol 9.78 µM 2.58933665995864 0.00191857993115751 no 40 0.00480805154471851 105 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_633 0437-0093 97.7 µM 2.58091460976895 0.00197765234806476 no 41 0.00492694759165689 80 2831118
SGTC_1500 4488-1866 171 µM 2.55181868080725 0.00219466052025663 no 42 0.00535811359061241 96 2900003
SGTC_1345 1488-0192 31.4 µM 2.54830991514001 0.00222223896698385 no 43 0.0054123129950728 100 658348
SGTC_180 1486-1293 102.781 µM 2.54196629549585 0.00227289734380437 no 44 0.00551154012560488 140 4140536
SGTC_732 3970-1727 52.7 µM 2.51469182229609 0.00250283301150178 no 45 0.0059568236346211 85 1275699
SGTC_898 1000-0849 28.3 µM 2.49612966572201 0.0026711367238583 no 46 0.00627783480472682 69 6751807
SGTC_322 k048-0136 19.3 µM 2.46272547322595 0.00299994873870505 no 47 0.0068942722973644 98 6823282
SGTC_3341 9147222 25.867 µM 2.44715207737913 0.00316536101535662 no 48 0.00719950346329216 98 1939759
SGTC_842 0271-0008 11.1 µM 2.38487555047251 0.00391194278994623 no 49 0.00854244992856903 125 1221709
SGTC_1676 st018489 23.4 µM 2.37416401472019 0.00405518821759331 no 50 0.00879436779418305 168 3696235
SGTC_994 3910-0338 138 µM 2.37248978786522 0.00407799706640617 no 51 0.00883432577715132 162 3479481
SGTC_1399 3562-5772 25 µM 2.36514398493444 0.00417943565737942 no 52 0.0090115311774194 107 23847490
SGTC_3027 9089541 49.47 µM 2.35435532673738 0.00433251004203085 no 53 0.00927743245359988 142 9943819
SGTC_2247 cerulenin 830 nM 2.34546812338829 0.0044623491534456 no 54 0.00950160173475405 130 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 2.34533375384769 0.00446433863709041 no 55 0.00950502708065192 119 6857784
SGTC_3068 9116768 49.47 µM 2.33677390204131 0.00459272059949086 no 56 0.00972547176297061 145 41904888
SGTC_2643 anethole 100 µM 2.3264118381186 0.00475253444510735 no 57 0.00999829534713649 146 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2035 5154463 94.595 µM 2.31430231310413 0.00494556946962604 no 58 0.0103255725042407 162 2769623
SGTC_183 3914-0051 30.55 µM 2.30382107358868 0.0051182556343517 no 59 0.0106163448278994 132 1596232
SGTC_737 1950-0117 57.9 µM 2.30097052722356 0.00516613953584493 no 60 0.0106966485260496 149 5393513
SGTC_1312 1218-2183 165 µM 2.29924682910013 0.0051952875243512 no 61 0.0107454636101611 116 6744073
SGTC_2163 5671233 125 µM 2.29795579291203 0.00521721489292446 no 62 0.0107821526545441 165 701023
SGTC_1301 naphtanilide LB 4.81 µM 2.29054546286644 0.00534467429999038 no 63 0.0109948581392713 133 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2162 5663267 200 µM 2.26882610322679 0.00573434763970835 no 64 0.011639451463505 122 6456493
SGTC_1565 sinapyl alcohol 95.1 µM 2.26119863402141 0.00587706106321034 no 65 0.0118734798325381 170 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1883 5-benzylidenerhodanine 20 µM 2.26018067256262 0.00589634393942926 no 66 0.0119050199443527 237 1273210
SGTC_845 0330-0138 4.51 µM 2.2400836987679 0.00628869567707727 no 67 0.0125427448063817 156 9039800
SGTC_553 k007-0256 45.7 µM 2.23609573283099 0.0063692454098207 no 68 0.0126727504582078 168 6287000
SGTC_642 0335-0876 158 µM 2.2360092922777 0.00637100141816252 no 69 0.012675581240158 177 6812350
SGTC_1825 st052143 62.6 µM 2.23313360002817 0.00642966482437194 no 70 0.0127700677220468 124 674173
SGTC_1173 0443-0020 122 µM 2.22838606106722 0.00652755972812154 no 71 0.0129273908986783 206 5331295
SGTC_2112 5488546 200 µM 2.20873319255971 0.00694696872871415 no 72 0.0135966021351109 158 600757
SGTC_152 4469-0003 551.229 µM 2.20676060336708 0.00699035166512667 no 73 0.0136653943912121 149 697280
SGTC_1229 0139-0193 12.2 µM 2.20060205752929 0.00712733859125483 no 74 0.013882103907274 165 3090752
SGTC_3346 9158254 43.5805 µM 2.18755157499769 0.00742547608931371 no 75 0.014351141247489 169 17639500
SGTC_2545 solidagenone 89.61 µM 2.17989048978712 0.00760556579821659 no 76 0.0146327900276904 60 6708572 An anti ulcer agent
SGTC_1293 1000-1278 195 µM 2.17853077756792 0.00763792743998281 no 77 0.0146832717136092 179 678847
SGTC_692 k241-0027 77.8 µM 2.16612569024084 0.00793881581324198 no 78 0.0151507917798954 155 3600480
SGTC_973 1325-0077 65.9 µM 2.14582341912077 0.00845377009740943 no 79 0.0159435347269082 182 2835149
SGTC_2795 7780010 54.55 µM 2.1453993836454 0.00846483100758978 no 80 0.0159604641728802 184 953673
SGTC_2327 6189656 200 µM 2.14174903830478 0.00856057627110155 no 81 0.016106841148633 163 5349088
SGTC_1358 1509-0022 2.48 µM 2.12887407055126 0.00890590203123806 no 82 0.0166323402895515 170 3258434
SGTC_2381 9035592 200 µM 2.12649995560205 0.00897089535070283 no 83 0.0167308264737475 169 4749657
SGTC_1503 4585-0012 61.3 µM 2.12234187293519 0.00908572776698805 no 84 0.0169045197974669 170 2922052
SGTC_75 0159-0059 199.013 µM 2.12110013261346 0.00912026916212292 no 85 0.0169566884007816 177 5377270
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 2.10518037213056 0.00957339895668679 no 86 0.017637805069502 146 61125 An anti-inflammatory.
SGTC_1179 1021-1431 9.29 µM 2.10100601972733 0.0096954240143407 no 87 0.0178202189126003 259 2840958
SGTC_3116 9124943 49.47 µM 2.09676517968471 0.00982078215207259 no 88 0.0180071836988224 181 41905195 YPL160W CDC60
SGTC_2620 irigenin 100 µM 2.09522765853651 0.00986657928566021 no 89 0.0180753798453735 220 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2658 polymyxin b sulfate 77.05 µM 2.09517165302362 0.0098682509996796 no 90 0.0180778680982265 206 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1401 3807-4679 7.6 µM 2.08493914609889 0.0101778633397914 no 91 0.0185374123586129 169 3291456
SGTC_3012 9080433 71.4286 µM 2.0787217099883 0.0103700991339619 no 92 0.0188214681794702 179 17688859
SGTC_2971 9092186 9.93 µM 2.07718320535172 0.0104181536149945 no 93 0.0188923266698051 192 25236400
SGTC_1418 3966-3099 2.4 µM 2.07609624876721 0.0104522210992813 no 94 0.0189425250268277 211 740335
SGTC_1207 2099-0101 141 µM 2.06634755337525 0.0107621306963143 no 95 0.0193978371468642 206 5837381
SGTC_2650 prasterone 100 µM 2.05689532887115 0.011070223676128 no 96 0.0198481477047157 108 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_861 0443-0273 110 µM 2.05418976303722 0.0111598112052536 no 97 0.0199786644091046 186 6149169
SGTC_1815 st051655 58.2 µM 2.05102676785514 0.0112653439578824 no 98 0.0201321700263265 138 5984156
SGTC_979 1426-2828 121 µM 2.04965621579211 0.0113113408758931 no 99 0.0201989952429974 235 747872
SGTC_894 0960-0238 55.9 µM 2.04700520568799 0.0114007744309443 no 100 0.0203287867109704 154 6741907 YDL195W SEC31
SGTC_38 0929-0051 58.268 µM 2.04283162633219 0.0115428178350104 no 101 0.0205345543193356 231 1379719
SGTC_1912 st060209 90.8 µM 2.03791999896103 0.0117119463222026 no 102 0.0207789671009565 222 688787
SGTC_1499 4480-0877 67.3 µM 2.03768625332673 0.0117200485327687 no 103 0.0207906599115615 132 2861909
SGTC_3342 9147791 14.508 µM 2.02894368441668 0.0120266019033713 no 104 0.0212320133130732 193 1838168
SGTC_706 4262-0057 46.9 µM 2.02600578841488 0.0121311668325971 no 105 0.0213820957376837 220 883298
SGTC_209 4077-0173 175.592 µM 2.02099775010045 0.0123112289348139 no 106 0.0216399989991274 123 15993494
SGTC_1411 3909-8223 150 µM 2.01802345884961 0.0124192606903537 no 107 0.0217944091092155 194 X1411
SGTC_3096 9117468 49.47 µM 2.01249697441212 0.0126221740721347 no 108 0.0220837876494727 125 41316311
SGTC_1393 3470-5649 58.2 µM 2.01125008969148 0.0126683500925007 no 109 0.0221495237076593 155 4108395
SGTC_1392 3455-1037 33.9 µM 2.00167104627245 0.0130279925432863 no 110 0.0226600611830495 203 981132
SGTC_735 3076-0345 636 µM 1.9978943998235 0.0131721928459289 no 111 0.0228640549606608 261 2888990
SGTC_1164 k060-0068 93.7 µM 1.9946633076899 0.0132966554118055 no 112 0.0230398069087856 245 5963676
SGTC_1711 st032263 62.8 µM 1.98630369770981 0.0136233939851703 no 113 0.0234998061574688 195 3958979
SGTC_2916 7875993 68.79 µM 1.98515538326286 0.0136688131400826 no 114 0.0235635932700243 241 1299250
SGTC_1811 st050069 61.5 µM 1.97129443802233 0.0142274426354097 no 115 0.0243451035936077 155 3877702
SGTC_1269 0831-0796 3.05 µM 1.96987123247858 0.0142858993273884 no 116 0.0244265650830546 215 927758
SGTC_2753 fluvastatin 17.09 µM 1.95157365495109 0.0150560737864151 no 117 0.0254944217991589 259 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_3026 9090633 49.47 µM 1.93525654616567 0.015772722891081 no 118 0.0264794109238992 234 25236842
SGTC_1814 st052110 31.539 µM 1.93209057619417 0.0159151108474408 no 119 0.0266741636428446 201 674163
SGTC_2592 piperlongumine 83.33 µM 1.92517106295783 0.0162301533229932 no 120 0.0271039804885938 249 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_3349 9149703 23.001 µM 1.92240640343012 0.0163575126108199 no 121 0.027277320240408 211 4910494
SGTC_3255 9139072 49.47 µM 1.9223711584414 0.0163591417471765 no 122 0.027279536000518 224 17646060
SGTC_1032 k061-1018 98.7 µM 1.92158851352095 0.0163953539201502 no 123 0.0273287775317286 292 4005393
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.90814242919198 0.0170282916693246 no 124 0.0281864050551894 267 688761
SGTC_1495 4469-0029 237 µM 1.90200053552662 0.0173242838052841 no 125 0.0285855422926034 400 793680
SGTC_2784 7567673 72.73 µM 1.90159761145258 0.0173438543260925 no 126 0.0286118902240478 294 3471247
SGTC_2328 6201408 200 µM 1.90053615882317 0.0173955008084618 no 127 0.0286813972327897 241 2890418
SGTC_3343 9148379 18.9835 µM 1.89539342894283 0.0176475911622679 no 128 0.0290201493010136 222 1955036
SGTC_1041 0206-0046 107 µM 1.88984133257516 0.017923241500131 no 129 0.0293895918951827 246 50494
SGTC_3262 9137218 49.47 µM 1.88653261423275 0.0180892523805906 no 130 0.0296116088605053 113 17650664
SGTC_2584 androsterone 48.74 µM 1.8775797215255 0.0185450382731826 no 131 0.0302193409933481 429 2754130 A steroid.
SGTC_2025 5147754 141 µM 1.86444333724722 0.0192314813867277 no 132 0.0311297358924944 218 315777 YLR208W SEC13
SGTC_1383 3049-0032 20.7 µM 1.85817545370288 0.0195665478084884 no 133 0.0315720512879631 267 712864
SGTC_1704 st028805 70.8 µM 1.8581694709053 0.0195668699882636 no 134 0.0315724759537935 237 2876101
SGTC_307 1501-1223 22.3 µM 1.85715109138962 0.0196217764586122 no 135 0.0316448305259059 235 2830329
SGTC_2015 5119600 184 µM 1.8496057398639 0.0200326778560883 no 136 0.032185197466263 275 2828786
SGTC_2532 xanthone 78.9 µM 1.83501761812739 0.0208478302206062 no 137 0.0332515395220898 272 7020 An insecticide.
SGTC_634 1611-4317 11.2 µM 1.83462494091956 0.0208701546727784 no 138 0.0332806402980281 291 2843522
SGTC_3003 9075612 71.4286 µM 1.82697469959515 0.0213091396922032 no 139 0.0338517867630806 256 6501993
SGTC_748 act1.228 77.9 µM 1.82475052530544 0.0214382226661649 no 140 0.0340193424622 353 4421505 YNR035C ARC35
SGTC_1878 temozolomide 1 mM 1.82142662859953 0.0216323612382729 no 141 0.0342710152133455 227 5394 DNA alkylating agent.
SGTC_772 k072-0172 35.3 µM 1.8205943508542 0.0216812039091807 no 142 0.0343342710969958 254 5861980
SGTC_194 1486-1323 56.904 µM 1.81878205675916 0.0217878817739164 no 143 0.0344723434688058 256 5178754
SGTC_2671 danthron 100 µM 1.8167916165491 0.0219055564583814 no 144 0.0346245134905421 282 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_3080 9117754 49.47 µM 1.8150857881175 0.0220068315399916 no 145 0.0347553634364265 294 9550191
SGTC_1203 3992-3522 103 µM 1.81500354952212 0.0220117240189234 no 146 0.0347616820045169 302 5322312
SGTC_2861 9024595 19.48 µM 1.81095596100228 0.0222536575081998 no 147 0.035073834484697 156 16482810
SGTC_2353 9059630 146.67 µM 1.80529439272565 0.022595823096023 no 148 0.0355143133139398 227 4779114
SGTC_277 nystatin 15.5 µM 1.79461252035953 0.0232534822587017 no 149 0.0363577284645884 298 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2812 7970281 58.44 µM 1.79187812555143 0.0234243996481758 no 150 0.036576245325139 332 2233435
SGTC_662 k832-1615 104 µM 1.79183977930679 0.0234268040325549 no 151 0.0365793173558551 280 5878478
SGTC_2167 5876490 200 µM 1.79015603413085 0.023532583066933 no 152 0.036714415409663 300 686534
SGTC_1656 st012921 11 µM 1.78652363376737 0.0237621526049548 no 153 0.0370072570424033 241 6732821
SGTC_2433 5607874 27.82 µM 1.7801050690211 0.0241724123238078 no 154 0.0375293835881304 316 2252428
SGTC_2057 5236571 38.335 µM 1.77822909111052 0.0242934381361085 no 155 0.037683118441888 351 54684039 YBR257W POP4
SGTC_1377 2944-0135 198 µM 1.75860823154707 0.0255900150048785 no 156 0.0393220369404513 330 1894137
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.75787616378011 0.0256394913732778 no 157 0.0393842911893349 330 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1087 pterostilbene 9.05 µM 1.75491158779868 0.0258406700252015 no 158 0.0396372158853173 322 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1882 5615643 20 µM 1.74764827089372 0.0263391533692521 no 159 0.0402624756533917 262 2253075
SGTC_326 k292-0812 17.5 µM 1.743237624562 0.0266457612514208 no 160 0.0406460579157465 248 3579357
SGTC_1688 st021091 57.6 µM 1.74270190901296 0.0266832039732655 no 161 0.040692849015812 254 3656366
SGTC_1620 st003704 16.5 µM 1.74062899538231 0.0268285002012719 no 162 0.0408743158680625 264 2834414
SGTC_249 wiskostatin 11.211 µM 1.73036577016559 0.027557643815574 no 163 0.0417824727418059 278 2775510 A n-wasp and actin depolymerizer.
SGTC_1013 4112-3890 241 µM 1.73025536537631 0.0275655763732124 no 164 0.0417923301931551 319 705171
SGTC_2879 9041815 71.43 µM 1.72897601630837 0.0276576362009408 no 165 0.0419066938187729 192 4942971
SGTC_1701 st028638 40.4 µM 1.72785012517794 0.0277388652961296 no 166 0.0420075490180097 313 3490878
SGTC_1956 st077085 54 µM 1.72764655243192 0.0277535735565631 no 167 0.0420258056374695 349 24208685
SGTC_3236 9132701 49.47 µM 1.72082221935999 0.0282504091431875 no 168 0.0426415445826667 303 24282524
SGTC_1209 2323-2347 50.3 µM 1.71992548960491 0.0283162412115625 no 169 0.0427229932500006 276 5412760
SGTC_762 1165-0429 115 µM 1.71819804343042 0.02844341896535 no 170 0.0428802491521563 317 5967793
SGTC_3299 9121982 43.1275 µM 1.71812010473711 0.0284491681415499 no 171 0.042887355217548 324 17594604 YPL160W CDC60
SGTC_1707 st032323 6.317 µM 1.71496189422468 0.028682949347207 no 172 0.0431761067667285 356 3132057 YMR211W DML1
SGTC_2719 novobiocin 32.65 µM 1.71215648541144 0.0288919527454706 no 173 0.0434339170826882 212 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_896 0964-0007 44.5 µM 1.70441042177909 0.029475617509694 no 174 0.0441522191294044 281 6756758
SGTC_984 1492-0255 2.91 µM 1.70224360498771 0.0296406279240008 no 175 0.0443548558525275 301 1585198
SGTC_2605 digitonin 300 nM 1.69916875714505 0.0298761031469219 no 176 0.0446436956360446 389 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1052 3253-3998 198 µM 1.69442618067836 0.0302423356450449 no 177 0.045092164038755 370 5450317
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.6943434936442 0.0302487537810742 no 178 0.0451000151437627 406 688788
SGTC_2646 retinol 96.75 µM 1.68942130083386 0.0306328512270484 no 179 0.0455693609048364 304 445354 A vitamin A analog and teratogen.
SGTC_884 0851-0618 334 µM 1.68902174066019 0.0306642068823177 no 180 0.0456076318571184 360 9642473
SGTC_1505 k297-0037 20.6 µM 1.68807643750378 0.0307384957834924 no 181 0.0456982784362219 337 4089396
SGTC_3197 9113331 49.47 µM 1.68407201271145 0.0310548475298136 no 182 0.0460838762058618 361 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1514 1189-1591 158 µM 1.68289489062252 0.0311483515115041 no 183 0.0461977204389304 399 767698 YMR146C TIF34
SGTC_2326 6164455 177.58 µM 1.67315376491753 0.0319311039771442 no 184 0.0471485147849469 327 2888790
SGTC_1394 3474-0001 65.7 µM 1.67268756293464 0.0319689695647131 no 185 0.0471944094412143 287 5017666 YIL048W NEO1
SGTC_263 alizarin 107.927 µM 1.66785595134924 0.0323635878146792 no 186 0.0476721628360255 440 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_162 k030-0015 37.8 µM 1.66674103609178 0.0324552161669113 no 187 0.0477829546736699 322 1809920 YMR134W ERG29
SGTC_501 nsc-95397 161 µM 1.66657886596656 0.0324685617913043 no 188 0.0477990870743202 297 262093
SGTC_964 1287-0107 19.4 µM 1.66333770164796 0.0327362409012876 no 189 0.0481224279472435 377 51516812 YPR165W RHO1
SGTC_2621 lithochol-11-enic acid 100 µM 1.6529951902271 0.033602592943539 no 190 0.0491659212262437 392 6708711
SGTC_2959 9079155 11 µM 1.65075523412322 0.0337926901438081 no 191 0.0493942821823829 297 16189457
SGTC_1281 0884-0031 11.8 µM 1.65074702468157 0.0337933884741861 no 192 0.0493951206802288 385 1548255
SGTC_1189 1431-2119 7.28 µM 1.6463055340705 0.0341729453173287 no 193 0.0498504353464384 396 3107275
SGTC_1834 st055981 52.8 µM 1.64511689023178 0.0342751157082022 no 194 0.0499728540512348 353 471719 YDL150W RPC53
SGTC_23 0213-0011 39.996 µM 1.6424701449246 0.0345035199481896 no 195 0.0502463042119596 332 627608
SGTC_1872 amphotericin b 148 nM 1.63959177330327 0.0347533305100804 no 196 0.0505450373771436 352 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1636 st007707 68.9 µM 1.63554550445323 0.0351070109707306 no 197 0.0509673718350122 400 403051
SGTC_726 3448-4391 34.2 µM 1.63355735692647 0.0352818721087329 no 198 0.0511759139779959 379 1356692
SGTC_1347 1493-0251 600 nM 1.6324855309306 0.0353764371158038 no 199 0.0512886220496943 363 3986378
SGTC_1051 3253-3903 78 µM 1.62792128061674 0.0357814615149581 no 200 0.0517707892238397 393 5509239
SGTC_535 2293-4129 48.2 µM 1.62658088851288 0.035901125019302 no 201 0.0519130705131783 442 396118 YIL048W NEO1
SGTC_324 1315-0088 19.6 µM 1.6263613255892 0.0359207577137662 no 202 0.0519364064890531 283 6787421
SGTC_1058 3448-5425 97.3 µM 1.62629421445238 0.0359267603561434 no 203 0.0519435409768642 341 7279705
SGTC_2139 5578692 56.4705 µM 1.62553983364843 0.0359942912230903 no 204 0.052023791694684 306 650991 YMR113W FOL3
SGTC_3132 9126706 49.47 µM 1.62423922949701 0.03611096318902 no 205 0.0521623806997189 338 850858
SGTC_746 1095-0025 46.6 µM 1.6241195959185 0.0361217105714084 no 206 0.0521751432566501 369 6749286
SGTC_2764 methyldopa 94.69 µM 1.62162542592736 0.0363463735915928 no 207 0.0524417875620848 384 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2923 7992654 58.14 µM 1.62091596099994 0.0364104873549945 no 208 0.0525178316466939 364 2985126
SGTC_2907 7721985 69.9 µM 1.62047184505428 0.0364506688316675 no 209 0.0525654787950993 368 3267881
SGTC_1176 0848-0131 83.3 µM 1.61979911314401 0.0365116034899688 no 210 0.052637718434119 389 6769040
SGTC_2602 kawain 100 µM 1.61893830333367 0.0365896953865065 no 211 0.0527302692261065 410 5369129
SGTC_878 0828-0289 13.7 µM 1.61856610620164 0.0366235030654707 no 212 0.0527703263192349 440 745350 YLR208W SEC13
SGTC_1215 3852-0577 11.2 µM 1.6181034801945 0.0366655602613439 no 213 0.0528201493178749 388 2884876
SGTC_3242 9133940 49.47 µM 1.61496863052913 0.0369515904594685 no 214 0.0531587441531782 333 17248444
SGTC_2245 6637752 200 µM 1.60759429283886 0.0376316369201129 no 215 0.0539620314920873 287 681890
SGTC_728 3030-5151 22.5 µM 1.60600505873292 0.037779523099591 no 216 0.0541363992323815 324 3125388
SGTC_2931 9014674 55.67 µM 1.602569687834 0.038100822634085 no 217 0.0545148452450888 376 2996810
SGTC_2747 doxorubicin 7.63 µM 1.60135111531598 0.0382153260538846 no 218 0.054649586779723 217 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1266 0828-0227 32.9 µM 1.60046201999923 0.0382990470191323 no 219 0.0547480629947092 349 3913820
SGTC_2596 sinensetin 100 µM 1.60037404570789 0.0383073391738453 no 220 0.0547578146510851 359 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1330 1469-0054 61.8 µM 1.595866499267 0.0387341677881966 no 221 0.0552593012262877 356 7102664
SGTC_284 0988-0104 32.6 µM 1.59450276734248 0.0388640630271516 no 222 0.055411735705945 376 4666532
SGTC_1152 3909-8331 15.9 µM 1.58350782597268 0.0399243383253604 no 223 0.0566528821734433 347 16001939
SGTC_1371 2421-0008 32.7 µM 1.58302378944129 0.0399715504381383 no 224 0.0567080211340043 402 2827552
SGTC_651 3253-0966 34.4 µM 1.57961950524065 0.0403048817072627 no 225 0.0570970148120322 409 781462
SGTC_1923 st058458 19.1 µM 1.57779175263398 0.0404847758331812 no 226 0.0573067295780593 433 3534982
SGTC_438 sphingosine 6.67 µM 1.57685097114059 0.0405776248084992 no 227 0.0574149100737083 317 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1026 k007-1105 30.6 µM 1.57554269361225 0.040707030477109 no 228 0.0575656159401168 476 7066794
SGTC_1822 st052468 42 µM 1.57229464652852 0.0410297528150491 no 229 0.0579411170111715 343 2873678
SGTC_305 1682-2595 20.8 µM 1.5715083704221 0.0411081874801986 no 230 0.058032305834623 372 226033
SGTC_1093 fluphenazine 7.97 µM 1.57064256822989 0.0411946958454004 no 231 0.0581328481728322 437 6602611 An atypical antipsychotic.
SGTC_3110 9122132 49.47 µM 1.56980208714267 0.0412788153285737 no 232 0.0582305809393319 377 918317
SGTC_1678 st019265 80.2 µM 1.56897721068559 0.0413615083583569 no 233 0.0583266246300268 424 5367020
SGTC_810 3825-7150 143 µM 1.5676692797091 0.0414929022934555 no 234 0.0584791673107493 385 22330411 YGL099W LSG1
SGTC_3062 9077494 49.47 µM 1.56676153509523 0.0415842924216286 no 235 0.0585852206880679 373 16459633
SGTC_2338 7999974 200 µM 1.55811725966814 0.0424627775910382 no 236 0.0596027269781784 410 315925
SGTC_591 4299-0174 154 µM 1.55775059382726 0.0425003697830401 no 237 0.0596461909922377 350 5509088
SGTC_840 0245-0196 390 µM 1.55638839009311 0.0426402646847926 no 238 0.0598078821263099 427 3827528
SGTC_3295 9122362 53.5725 µM 1.55441236779194 0.0428438587092199 no 239 0.0600430424929303 373 4730473
SGTC_1692 fluoroquinolonic acid 71 µM 1.54686140175821 0.043629099580355 no 240 0.0609483351005157 343 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2182 6325192 200 µM 1.54057513338003 0.0442916450311735 no 241 0.0617101119088201 362 736248
SGTC_3296 9122258 64.045 µM 1.54041288246797 0.0443088523337464 no 242 0.061729871609629 408 4730474
SGTC_1248 0469-0687 58.6 µM 1.53942625994067 0.0444136032839394 no 243 0.0618501336343102 416 4017482
SGTC_701 4424-0219 185 µM 1.53741364839108 0.0446279034591727 no 244 0.0620960231116574 437 2911779
SGTC_1476 4112-3294 3.34 µM 1.53692136242713 0.0446804479813197 no 245 0.0621562837595892 378 704369
SGTC_2290 7904846 200 µM 1.53676500487679 0.0446971473469619 no 246 0.0621754330058783 415 2962154
SGTC_3228 9131799 49.47 µM 1.53590325297791 0.0447892747538472 no 247 0.0622810551069633 373 17015818
SGTC_2017 5132927 60.65 µM 1.5321303608842 0.0451944253500539 no 248 0.0627451344833432 415 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_530 4358-1714 28 µM 1.5319582039608 0.0452129824722345 no 249 0.062766374522355 474 1564641
SGTC_1107 amlodipine 47 µM 1.53171969425719 0.0452387020163712 no 250 0.0627958101622777 424 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_2486 5283202 22.39 µM 1.53130496226937 0.045283452407559 no 251 0.0628470198624073 409 1377751
SGTC_1910 st062352 60.4 µM 1.52952538138876 0.0454758770499304 no 252 0.0630671259177757 423 2245730
SGTC_2358 9037157 4 µM 1.52883076901772 0.0455511631139407 no 253 0.063153201231269 400 2388925
SGTC_2466 5983409 37.09 µM 1.52639140520124 0.0458163495867985 no 254 0.063456208421104 407 2879657
SGTC_767 0929-0023 86 µM 1.5232029990697 0.0461648345628583 no 255 0.0638539630082342 521 1204563
SGTC_1244 0416-0015 52.5 µM 1.5190102998726 0.0466263229919072 no 256 0.0643799517004508 417 96201
SGTC_1453 4237-0541 195 µM 1.51880292277377 0.0466492446239946 no 257 0.0644060549991061 396 739892
SGTC_2379 9035213 200 µM 1.51663891061179 0.0468889752484565 no 258 0.0646789378514336 441 646551
SGTC_775 4577-0580 57.3 µM 1.51589786812464 0.0469712951528643 no 259 0.0647725897351814 400 2006902
SGTC_3032 9089427 49.47 µM 1.51501088526835 0.0470699794155905 no 260 0.064884823757883 385 17173707
SGTC_356 1634-0012 32.5 µM 1.51185447134397 0.0474225058687402 no 261 0.0652854442577098 457 735457
SGTC_1121 fusaric acid 630.51 nM 1.51100604671919 0.0475176226667735 no 262 0.0653934551458984 427 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2218 6965428 192.983 µM 1.50994028684237 0.0476373214026584 no 263 0.0655293308132235 393 675684
SGTC_32 0928-0142 34.1 µM 1.509805137144 0.0476525177155753 no 264 0.065546576924856 359 2244242
SGTC_1748 st037455 53.6035 µM 1.50827035338046 0.0478253622472542 no 265 0.0657426738225934 436 580690
SGTC_1946 st076057 65.1 µM 1.50530954354803 0.048160221203007 no 266 0.0661222563582216 282 953009
SGTC_1368 1852-0141 284 µM 1.50255264837182 0.0484737021573889 no 267 0.066477220893916 417 2838987
SGTC_1470 k295-0292 231 µM 1.50045070102153 0.0487138049179729 no 268 0.0667488472855338 431 5045612
SGTC_2217 6934799 96.0675 µM 1.50038030052557 0.0487218630998879 no 269 0.0667579597066226 393 675606
SGTC_2917 7979103 53.79 µM 1.49937110069587 0.048837495285966 no 270 0.0668886932209052 479 2980565
SGTC_2430 5571206 200 µM 1.49636960316185 0.0491826976104758 no 271 0.0672786830888393 478 1731771
SGTC_470 aa-861 153 µM 1.49531151676215 0.0493048516957874 no 272 0.0674165804027981 472 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_659 k018-0002 107 µM 1.49423854986047 0.0494289709609066 no 273 0.0675566400273401 427 6797879 YHR007C ERG11
SGTC_3010 9080089 71.4286 µM 1.49057458099432 0.0498546946683566 no 274 0.0680366110360469 404 17027233
SGTC_598 3937-0236 20.2 µM 1.49035614535714 0.0498801672251697 no 275 0.0680653085177759 481 1379313
SGTC_895 0964-0006 13.7 µM 1.48995359917577 0.0499271367587245 no 276 0.0681182184211114 415 6738897
SGTC_2043 5101342 149 µM 1.48716012903403 0.0502540543930747 no 277 0.068486261860726 435 678451
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.48666448805503 0.050312236693265 no 278 0.0685517231657134 437 5377381
SGTC_693 4161-2696 114 µM 1.48632636981488 0.0503519585091122 no 279 0.0685964074920853 353 805759
SGTC_2763 lisinopril 49.32 µM 1.48019934175385 0.0510760947759992 no 280 0.0694100280293358 382 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2594 a-mangostin 100 µM 1.47831589527551 0.0513003519070081 no 281 0.0696616225388024 471 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1472 k841-0093 193 µM 1.47664140339606 0.0515003864723122 no 282 0.0698858935222113 480 X1472
SGTC_1130 3454-2858 15.9 µM 1.47633716464919 0.051536797288721 no 283 0.0699267009416202 461 715628 YIL048W NEO1
SGTC_1717 st033143 58.0435 µM 1.47049965520576 0.0522393934728585 no 284 0.0707132394977597 491 674616
SGTC_1875 nocodazole 6 µM 1.46920125225084 0.0523966972682781 no 285 0.0708891053783017 430 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_319 1348-1596 45.5 µM 1.46912373548854 0.0524061004430596 no 286 0.070899615475691 457 5380505
SGTC_2714 st079313 56.9 µM 1.46397840393835 0.0530332566226464 no 287 0.0715999245719075 416 2939799
SGTC_2968 9090663 33.37 µM 1.46264226459185 0.0531970861494374 no 288 0.0717826459803132 441 25236811
SGTC_901 1112-0062 60.1 µM 1.46184276043703 0.0532953083381262 no 289 0.071892151684774 416 1908457
SGTC_1369 1866-0067 208 µM 1.46034958648056 0.0534791354366682 no 290 0.0720970102599017 504 3531355
SGTC_393 acivicin 6.25 µM 1.45727042062671 0.0538598026650886 no 291 0.0725208742441275 403 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2918 7977171 22.06 µM 1.45539552457534 0.0540926388449952 no 292 0.0727798973488202 419 2236483
SGTC_2420 aureobasidin a 50 nM 1.45404788030533 0.0542604892121728 no 293 0.0729665160114456 496 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_962 1254-0300 21.5 µM 1.45186565219561 0.0545331614485836 no 294 0.0732694823506084 445 7340576
SGTC_1491 4138-0063 26.5 µM 1.44837506257773 0.0549715668543808 no 295 0.0737560925774705 399 23883227
SGTC_1556 plumbagin 1.48 µM 1.44424072722849 0.0554944220713889 no 296 0.0743356361429717 387 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_982 1491-0518 27.5 µM 1.44002175568588 0.0560320204555734 no 297 0.0749306220239664 418 3091256
SGTC_1403 3909-7815 62.9 µM 1.43946982124271 0.0561026529739165 no 298 0.0750087272359658 401 6615483
SGTC_3176 9106582 49.47 µM 1.43789266772652 0.056304872529064 no 299 0.0752322552268925 277 17018027
SGTC_556 4058-0063 51.5 µM 1.43735463510912 0.056373989319509 no 300 0.0753086259779695 491 6615692
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.43377547690528 0.0568354790271599 no 301 0.0758181726393604 431 229346 A bile salt which induces apoptosis.
SGTC_1421 4029-0249 71.4 µM 1.43265559572929 0.0569804838437289 no 302 0.075978142591888 491 2894095
SGTC_2207 7258803 200 µM 1.42618111058015 0.0578245331150478 no 303 0.0769080353303633 404 3666799
SGTC_2684 capsaicin 100 µM 1.42426844008123 0.0580757511144994 no 304 0.0771843898423921 446 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3165 9101544 49.47 µM 1.41978005962509 0.0586686411010153 no 305 0.0778358609555979 484 5002184
SGTC_753 1322-0200 289 µM 1.41841118705311 0.058850403912946 no 306 0.0780353756902919 461 5403907
SGTC_48 0382-0018 55 µM 1.41774993785445 0.0589383646154711 no 307 0.0781318923869485 431 762596
SGTC_2876 9059903 25.97 µM 1.41683173074801 0.0590606774031894 no 308 0.0782660650927084 484 6916095
SGTC_1230 0170-0365 3.77 µM 1.41269427215992 0.0596142928083093 no 309 0.0788728182309145 632 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.40085982139948 0.0612202751456738 no 310 0.0806279978242046 471 4330530
SGTC_352 k048-0007 5.11 µM 1.40021924968418 0.0613081585018552 no 311 0.0807238365721886 537 6811911
SGTC_193 1273-0060 1.558 µM 1.39646263764548 0.061825533025717 no 312 0.081287612063862 381 2847393 YHR072W ERG7
SGTC_1734 st037168 69.4 µM 1.39322257223008 0.0622744986282603 no 313 0.0817762480133585 476 708907
SGTC_2891 9063876 19.48 µM 1.3932112782439 0.0622760680355874 no 314 0.081777955128944 393 6472478
SGTC_1076 itraconazole 331 nM 1.38299322813018 0.0637086458139235 no 315 0.0833334711571091 500 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.38136199258026 0.0639397006161963 no 316 0.0835838429806751 449 616764
SGTC_2137 5261020 140 µM 1.37983508189586 0.0641565683962121 no 317 0.0838187141637938 477 763655
SGTC_3215 9129942 49.47 µM 1.37913715586156 0.0642558853439855 no 318 0.0839262348907768 436 17682944
SGTC_2250 alverine citrate 130 µM 1.37873384330384 0.0643133323728359 no 319 0.0839884154100492 647 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2767 sibutramine 71.45 µM 1.37423687826199 0.0649565776965776 no 320 0.0846840776530808 502 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_3168 9103419 49.47 µM 1.37358896159976 0.0650496657926932 no 321 0.0847846628608672 369 16649256
SGTC_2487 5918373 44.05 µM 1.37255789693595 0.0651980153304868 no 322 0.0849449141894546 504 2876279
SGTC_676 falcarinol 140 µM 1.37141460356365 0.0653628191089071 no 323 0.0851228738109359 516 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2976 9009005 19.48 µM 1.37069109399939 0.0654672786052901 no 324 0.0852356361369834 491 2993148
SGTC_1089 terbinafine 2.25 µM 1.36911119423583 0.0656958327641866 no 325 0.0854822598309896 477 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3314 9135860 59.4275 µM 1.36872473548901 0.065751833370126 no 326 0.0855426676410379 500 25252478
SGTC_1805 st050013 60.3 µM 1.36702892731953 0.0659980055069458 no 327 0.085808119303167 445 4037144
SGTC_2047 4141938 200 µM 1.35640869839636 0.0675559645960833 no 328 0.0874845835997088 437 3807862
SGTC_2807 7945238 51.95 µM 1.35463311242316 0.0678191887039834 no 329 0.0877672391126685 527 17148797
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.35135900921512 0.0683066386559132 no 330 0.0882902289061057 490 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1529 apigenin 74 µM 1.34861155046689 0.0687177640772346 no 331 0.0887308843525327 548 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2690 usnic acid 100 µM 1.34553155431272 0.0691809155442772 no 332 0.0892268191852645 593 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2175 5807670 165.306 µM 1.3432050655271 0.0695323507830317 no 333 0.0896027909412477 484 241186
SGTC_606 k015-0008 38.6 µM 1.3430883499034 0.0695500177833813 no 334 0.0896216837306748 556 1970475
SGTC_2177 5811945 192 µM 1.33921658901214 0.0701380393757693 no 335 0.0902500867340023 511 5343475
SGTC_1856 st057054 55.7 µM 1.33908191917877 0.0701585608929502 no 336 0.0902720029585432 536 1266018
SGTC_644 1498-1197 63.3 µM 1.33881194075797 0.0701997151729242 no 337 0.0903159512637447 559 6741615
SGTC_2355 9061122 103.12 µM 1.33732644666018 0.0704264893418691 no 338 0.0905580509765248 504 5302957
SGTC_1323 1348-1351 11.2 µM 1.33338585197563 0.0710307855808837 no 339 0.0912026064410027 489 6989654
SGTC_45 0kpi-0036 14.9 µM 1.33079056179558 0.0714309471658244 no 340 0.0916289671832815 481 2795021
SGTC_792 4534-1957 155 µM 1.32995836494623 0.071559627279864 no 341 0.0917659947870964 509 1717904
SGTC_1546 5-methoxyflavanone 78.7 µM 1.32821066323344 0.0718304481052231 no 342 0.0920542613559503 567 147795
SGTC_1524 corynanthine 62.1 µM 1.32708557199712 0.072005205742897 no 343 0.0922401887336905 498 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_321 4534-3890 65.3 µM 1.32624795637105 0.0721355220500104 no 344 0.0923787896159953 525 699746
SGTC_403 arphamenine a 50 µM 1.32535633425522 0.0722744392552217 no 345 0.092526496269137 544 5487158 An arginine aminopeptidase inhibitor.
SGTC_182 3448-4371 550.524 µM 1.32439547300925 0.0724243735244309 no 346 0.0926858686416115 561 3491403
SGTC_2673 kobusone 100 µM 1.32326400083684 0.0726012355789523 no 347 0.092873799438233 495 6710676 An epoxy ketone and protein crosslinker.
SGTC_2362 9071156 126 µM 1.3213279859876 0.0729046238479031 no 348 0.0931960131976642 522 653133
SGTC_1813 st051246 8.6015 µM 1.32125059853759 0.072916771192111 no 349 0.0932089100514999 484 5291959
SGTC_2237 6667747 47.222 µM 1.32112434121181 0.0729365928630214 no 350 0.0932299540496179 498 729940 YDL015C TSC13
SGTC_3042 9091578 49.47 µM 1.31557943220238 0.0738111858072087 no 351 0.0941576203276099 475 25236497
SGTC_3087 9117406 49.47 µM 1.31387409056021 0.0740817729770338 no 352 0.0944442895663268 516 42546093
SGTC_555 4296-0685 37 µM 1.31352954208674 0.0741365345094584 no 353 0.0945022864933372 546 2908540 YHR072W ERG7
SGTC_1320 1313-0481 95.3 µM 1.30992524275625 0.074711246334157 no 354 0.0951105633600547 540 6813365 YLR208W SEC13
SGTC_3339 9145883 14.936 µM 1.30883623376284 0.0748855577985365 no 355 0.0952949151666694 502 2030670
SGTC_991 3996-0057 64.7 µM 1.30821641122088 0.0749849077084033 no 356 0.0953999586219433 532 715343
SGTC_2539 epi(13)torulosol 80 µM 1.30454215352763 0.07557591135847 no 357 0.0960243983749731 527 6708597
SGTC_2069 5228469 200 µM 1.30288283218685 0.075843973389912 no 358 0.096307382947452 512 2835210
SGTC_1042 0350-0096 82 µM 1.30247666236691 0.0759096999843798 no 359 0.0963767453907 531 3122515
SGTC_2709 st078560 56 µM 1.3006340917601 0.0762084104321605 no 360 0.0966918659550998 538 17250903
SGTC_464 bw-b 70c 158 µM 1.29968422004037 0.0763627490362012 no 361 0.0968546104607422 588 5353454
SGTC_912 3474-0017 2.18 µM 1.29266957946517 0.0775098853663498 no 362 0.0980626816858997 563 3360550
SGTC_34 0469-0683 81.75 µM 1.29258695231464 0.0775234753156083 no 363 0.0980769773441954 534 3690923
SGTC_826 1683-5028 118 µM 1.29140403800313 0.0777182314030877 no 364 0.0982818055800818 534 722377
SGTC_2696 st077691 74.316 µM 1.29089850323523 0.0778015762969538 no 365 0.0983694372522843 496 757133
SGTC_665 3914-0008 307 µM 1.29029020922673 0.0779019524760374 no 366 0.0984749575059731 544 1069549
SGTC_2382 9035899 200 µM 1.28934309003494 0.078058434664628 no 367 0.0986394184211941 566 6462679
SGTC_2970 9090938 41.86 µM 1.28093859830038 0.0794574799265858 no 368 0.100107616985832 643 17217104
SGTC_948 3448-0295 75.3 µM 1.28067941681916 0.0795009239943377 no 369 0.100153146197185 620 678569
SGTC_2372 9071633 200 µM 1.27772065213097 0.0799981475282207 no 370 0.100673970346749 610 21321366
SGTC_804 1595-0054 20.9 µM 1.27381840649665 0.0806575149552269 no 371 0.10136389016755 538 761523 Stimulates phospholipase C.
SGTC_2101 5377231 179.231 µM 1.27189541054414 0.0809839519169851 no 372 0.101705141362567 559 2844213
SGTC_1603 st002045 67.8 µM 1.27094617285588 0.081145456320502 no 373 0.101873899289694 560 5887985
SGTC_1321 1326-2144 215 µM 1.26953620943942 0.0813857975839565 no 374 0.102124942283126 539 3513030
SGTC_2798 7813637 45.45 µM 1.26499553530701 0.0821634465121179 no 375 0.102936464171273 567 956368
SGTC_1410 3909-8106 77.9 µM 1.2647033968148 0.0822136699724837 no 376 0.102988835923233 548 1039210
SGTC_965 1291-5240 308 µM 1.2619469074786 0.0826886952191742 no 377 0.103483945747359 591 2834598
SGTC_825 1988-2224 89.6 µM 1.25867655704525 0.0832549495975579 no 378 0.10407359113722 609 1180859
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.25769922927073 0.0834247363967149 no 379 0.104250275554736 651 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2635 hydroquinidine 100 µM 1.25485612969883 0.0839201350847529 no 380 0.104765496069037 576 442912 An experimental heart treatment.
SGTC_139 0099-0334 718.624 µM 1.2450830432447 0.0856399091435778 no 381 0.106550613229247 669 97690
SGTC_3188 9110789 49.47 µM 1.24196171047809 0.0861946937224508 no 382 0.107125344798715 610 849217
SGTC_1921 5740136 50 µM 1.23903910363544 0.0867165897397047 no 383 0.107665508519335 651 1774243
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.23847285214974 0.0868179789806186 no 384 0.107770391115004 568 75037 A free radical scavenger.
SGTC_1793 st048256 72.231 µM 1.23323398297056 0.0877602202066535 no 385 0.108744240039719 574 672022
SGTC_314 1671-0008 2.74 µM 1.23253088506151 0.0878872548666301 no 386 0.108875418420822 642 3913060
SGTC_2902 5787006 60.46 µM 1.22692520403098 0.0889049900589353 no 387 0.109925352267424 584 591003
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.22593537504093 0.08908560549962 no 388 0.110111497660341 652 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2623 humulene 100 µM 1.22578219946974 0.0891135800370105 no 389 0.110140323764521 522 6187145 An anti-inflammatory.
SGTC_646 4092-0839 27.3 µM 1.22237451455285 0.0897376190248096 no 390 0.110783016163488 611 877796
SGTC_849 0386-0493 241 µM 1.22110834564047 0.0899703146110364 no 391 0.111022500126567 569 726119
SGTC_2058 5236698 133 µM 1.21712176890201 0.0907058929583438 no 392 0.111778944658588 588 766665
SGTC_2692 st077426 47.7 µM 1.21645599188176 0.0908291716980375 no 393 0.111905632826459 623 25238571
SGTC_944 3370-0224 231 µM 1.21183511904045 0.0916882241740166 no 394 0.112787751031755 606 4580514
SGTC_649 1123-0311 367 µM 1.2114733176237 0.0917557388350151 no 395 0.112857027409994 668 693629 YIL048W NEO1
SGTC_2354 9060492 162 µM 1.20586080968317 0.0928077933030298 no 396 0.113935581894312 680 6471895
SGTC_1579 chlormadinone acetate 49.4 µM 1.20379445430412 0.0931973660242999 no 397 0.114334516849378 634 45114258 A steroidal progestin.
SGTC_420 mitomycin C 81.9 mM 1.20331672610946 0.0932876044894685 no 398 0.114426889447916 627 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_761 k216-0224 480 µM 1.2001816934236 0.0938813856811004 no 399 0.115034391738819 673 1340404
SGTC_131 0141-0277 33.849 µM 1.1987207918421 0.0941590341312996 no 400 0.115318265293711 623 1547771
SGTC_801 0866-0028 10.1 µM 1.19360968404835 0.0951351814258042 no 401 0.116315342042348 658 6849771
SGTC_543 3844-1095 191 µM 1.19207670066755 0.0954294068330725 no 402 0.116615585930614 674 4230703
SGTC_360 0957-0399 1.01 µM 1.19202985444493 0.0954384085608733 no 403 0.116624769687216 658 6752301 YPR165W RHO1
SGTC_2724 maprotiline 69.64 µM 1.19061401449359 0.0957107640184553 no 404 0.116902573669471 638 4011 A tricyclic antidepressant.
SGTC_1974 st069448 26.9 µM 1.1890360806006 0.0960149736672024 no 405 0.117212734600664 602 6323587 YNR016C ACC1
SGTC_418 lividomycin a 100 µM 1.18890675224106 0.0960399383523883 no 406 0.117238181389144 684 72394 An antibiotic.
SGTC_1570 verbenone 133 µM 1.18691770042856 0.0964244930417932 no 407 0.117630042369079 675 29025 A natural terpanoid with antifungal properties.
SGTC_1682 st012968 530 nM 1.18633261390222 0.0965378262170784 no 408 0.117745485909783 577 24207270
SGTC_2681 menadione 3.18 µM 1.18297957514018 0.0971892087020588 no 409 0.11840862113662 627 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_156 3474-0145 5.642 µM 1.17943262897338 0.0978817651808401 no 410 0.11911297439922 648 2265471
SGTC_2941 9056145 11.23 µM 1.17738575095175 0.0982830692796502 no 411 0.119520787270426 543 2119517
SGTC_600 1495-0418 41.6 µM 1.17593509321981 0.0985682091937517 no 412 0.119810407052619 612 5377768
SGTC_1903 st060211 78.3 µM 1.17354859016703 0.0990386148435055 no 413 0.120287941727721 682 688960
SGTC_150 3970-0969 77.2 µM 1.17176984700391 0.0993902910056958 no 414 0.120644735876187 726 6615640
SGTC_2587 piperic acid 92.2 µM 1.16937855878561 0.0998645110803226 no 415 0.121125572270634 596 5370536
SGTC_3223 9129970 49.47 µM 1.16820725609909 0.100097396026854 no 416 0.121361587155185 682 17248386
SGTC_2616 abietic acid 100 µM 1.16814292498234 0.100110198176321 no 417 0.121374559092949 694 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2444 5485484 36.41 µM 1.16448180197167 0.100840747459821 no 418 0.12211440698683 673 6790631
SGTC_1225 1216-0074 20.6 µM 1.16427780677592 0.100881567184881 no 419 0.122155723726897 638 4241466
SGTC_2216 7189485 200 µM 1.16385860592293 0.100965487677352 no 420 0.12224065855572 661 731273
SGTC_3253 9135987 49.47 µM 1.16377890153044 0.100981449584228 no 421 0.122256812255601 584 4182430
SGTC_2226 7298446 200 µM 1.16143538284569 0.101451594128318 no 422 0.122732443403311 603 3283010
SGTC_636 0kpi-0074 126 µM 1.15950412489575 0.101840229769002 no 423 0.123125378068992 623 616434
SGTC_3271 9137798 49.47 µM 1.15746737453543 0.102251266978894 no 424 0.12354073065563 574 6498326
SGTC_1139 k015-0024 46.9 µM 1.1565820244549 0.102430315525766 no 425 0.123721584920097 655 2766652
SGTC_1842 st055362 61.2 µM 1.1536872097267 0.103017338786817 no 426 0.124314214756708 706 676032
SGTC_1131 3454-3128 32.3 µM 1.15087495361228 0.103589956922293 no 427 0.124891841598122 697 710982
SGTC_2683 piperine 63.03 µM 1.14811435265768 0.104154300278286 no 428 0.125460679927281 641 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2050 5263056 171 µM 1.14672747434865 0.104438656305471 no 429 0.125747135883954 742 763468 YGL055W OLE1
SGTC_281 1672-3440 14.9 µM 1.14378905519478 0.10504298721458 no 430 0.126355564957016 726 6833000
SGTC_569 4130-2812 160 µM 1.14281698609395 0.105243464202944 no 431 0.126557292395879 540 743552
SGTC_2871 9038510 12.99 µM 1.14130717039057 0.10555539333191 no 432 0.126871059646828 710 4945164
SGTC_3209 9113616 49.47 µM 1.14097942977584 0.105623193030988 no 433 0.12693924160175 715 16649353
SGTC_1745 st081495 74 µM 1.13904170413121 0.106024693836859 no 434 0.12734288010501 733 13842402 YBL026W LSM2
SGTC_524 r073-0010 27.8 µM 1.13721810500413 0.106403553574864 no 435 0.127723560070877 664 2772106
SGTC_357 1325-0123 420 µM 1.13654364124525 0.106543923356622 no 436 0.127864555906641 645 1098503
SGTC_1913 st060213 96.1 µM 1.13412341126858 0.107048723429836 no 437 0.128371392310012 714 688959
SGTC_669 0108-0021 26.2 µM 1.1325321224744 0.107381565496406 no 438 0.128705393685929 791 17201
SGTC_2491 paeonol 100 µM 1.13141526477019 0.10761561824675 no 439 0.128940174802161 648 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2188 6126565 140.678 µM 1.12811746519774 0.108308861657994 no 440 0.129635157049003 633 874518
SGTC_2159 5658611 73.75 µM 1.12690993752142 0.10856350291723 no 441 0.129890280669898 671 793844
SGTC_325 2810-4341 181 µM 1.12651376552218 0.108647140702883 no 442 0.129974058643564 679 774970
SGTC_399 oxolinic acid 75 µM 1.12385444504348 0.109209762495787 no 443 0.13053738989288 667 4628 A DNA gyrase inhibitor.
SGTC_1699 st031318 29.054 µM 1.12029488547579 0.109966116304343 no 444 0.131294060421426 683 5340658
SGTC_2154 5570129 200 µM 1.11454427572758 0.111195964427322 no 445 0.132522880523238 712 673366
SGTC_283 0987-0079 11.7 µM 1.1132394912157 0.111476376293345 no 446 0.132802793036292 722 411556
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.11231622292058 0.111675101824442 no 447 0.133001105535471 704 5282309
SGTC_623 k072-0108 16.9 µM 1.1110851057042 0.111940483276218 no 448 0.133265859150869 682 5382803
SGTC_3286 9117135 37.221 µM 1.10682773888181 0.112861682848503 no 449 0.134184206411273 666 3438150
SGTC_2803 7707263 71.43 µM 1.10559875004685 0.113128612543714 no 450 0.134450115541475 667 2199229
SGTC_1796 st049173 110.4 µM 1.10211659948943 0.113887362203847 no 451 0.135205491854019 660 94134
SGTC_351 caspofungin 25 nM 1.10208203939481 0.113894910869897 no 452 0.135213003463042 832 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2074 5212007 75.395 µM 1.10190676966079 0.113933199028679 no 453 0.135251102604875 637 758611
SGTC_1081 sertraline 6 µM 1.10122023040327 0.114083263748707 no 454 0.135400409488171 733 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3059 1327-0034 3 µM 1.10071594331159 0.114193581189826 no 455 0.135510152550566 701 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1432 4049-0298 68.4 µM 1.10029482347529 0.114285763224796 no 456 0.135601843425002 686 741646
SGTC_215 1287-0124 461.5 µM 1.10026444756575 0.11429241448057 no 457 0.135608458847554 667 5560863
SGTC_3195 9113082 49.47 µM 1.10020202944869 0.114306082717889 no 458 0.135622053281605 681 17018038
SGTC_323 4013-0906 34.3 µM 1.09692409044967 0.115025517730146 no 459 0.136337288389575 695 2910086
SGTC_1210 3013-0140 750 nM 1.09563700943673 0.115308882085907 no 460 0.136618829396918 756 905973
SGTC_2525 harmine 47.85 µM 1.09500024223759 0.115449256363832 no 461 0.136758265178535 668 5280953 A monoamine oxidase inhibitor
SGTC_1489 4065-0444 182 µM 1.09193677036046 0.116126291089971 no 462 0.137430447091913 691 2877968
SGTC_952 1185-0122 232 µM 1.08875533520418 0.116832373797696 no 463 0.13813089638051 700 678600
SGTC_186 3455-3465 67.277 µM 1.08854358927257 0.116879476138401 no 464 0.138177602246248 633 755278
SGTC_53 0973-0023 39.979 µM 1.08784996340296 0.117033865695257 no 465 0.138330674197557 696 674768
SGTC_1 0258-0098 57.368 µM 1.08671682555878 0.117286394064419 no 466 0.138580987865506 623 6790032 YDR047W HEM12
SGTC_3212 9128307 49.47 µM 1.08549282730883 0.117559604693459 no 467 0.138851719395141 613 27243542
SGTC_2073 5212005 126 µM 1.08525765512083 0.117612149415363 no 468 0.138903777459652 631 691789
SGTC_1828 st055811 49 µM 1.08508711946019 0.117650262740302 no 469 0.138941535798204 685 5877589
SGTC_1817 st052116 64.4 µM 1.0789370647691 0.119030596145146 no 470 0.140307892187149 712 4361398
SGTC_1391 3442-0225 151 µM 1.07851632294171 0.119125444642105 no 471 0.140401700665265 680 5227075
SGTC_3260 9137109 49.47 µM 1.07273067956329 0.120435125125865 no 472 0.141695985507069 613 17478346
SGTC_211 3455-0679 143.504 µM 1.07263020309423 0.120457958948416 no 473 0.141718533890241 762 748649
SGTC_1384 3089-0840 101 µM 1.07120514677773 0.12078213903472 no 474 0.142038598967244 691 1069836
SGTC_1252 0493-0875 34.8 µM 1.0698887420104 0.121082147627508 no 475 0.142334695562326 697 3960963
SGTC_1936 st074407 74.3 µM 1.06819191565982 0.121469627102138 no 476 0.142716975363502 771 809813
SGTC_1998 st075797 76.8 µM 1.06660967837091 0.121831724174818 no 477 0.143074064124338 827 24208315
SGTC_934 2950-0684 338 µM 1.06065123251996 0.123202124561311 no 478 0.144424215170141 786 1121253
SGTC_3084 9116877 49.47 µM 1.05981770016649 0.123394689019618 no 479 0.144613771346624 675 27241325
SGTC_279 1273-0055 2.93 µM 1.0587541903003 0.123640689387915 no 480 0.144855870659888 800 2847562
SGTC_376 3970-0862 59.1 µM 1.05377561255696 0.124796849686947 no 481 0.145992830703064 768 3135186
SGTC_2253 7938677 135.83 µM 1.05322071757123 0.124926177698684 no 482 0.146119922693354 741 2301972
SGTC_995 3931-2021 34.6 µM 1.04990893274307 0.125699994233448 no 483 0.146879992112764 733 730143
SGTC_1568 digitonin 820 nM 1.04959943393046 0.125772480793855 no 484 0.146951158726491 796 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_430 0958-0115 16.4 µM 1.04835868113253 0.126063365594646 no 485 0.147236691412991 722 6833180
SGTC_2001 4023502 57.655 µM 1.04552842251073 0.1267286518835 no 486 0.14788940568452 752 108941 YCR052W RSC6
SGTC_2100 5377183 190 µM 1.04545238702265 0.126746558597763 no 487 0.147906967668299 817 2844202
SGTC_252 miconazole 1.30953 nM 1.0451620816576 0.126814943077901 no 488 0.147974032595439 735 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2408 sulbentine 18.36 µM 1.04378524258708 0.127139621795256 no 489 0.148292380390667 742 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1362 1611-0397 101 µM 1.04334323851218 0.127243975337766 no 490 0.148394676066921 752 27816
SGTC_2340 7987427 183.45 µM 1.04314399612647 0.127291034311752 no 491 0.148440803366042 736 2239331
SGTC_110 0850-0284 111.64 µM 1.0418976134109 0.127585691659895 no 492 0.148729575370767 626 3906265
SGTC_1569 carminic acid 40.6 µM 1.04173672938194 0.127623760783485 no 493 0.148766877624476 778 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1558 st069300 45.6 µM 1.0403873070236 0.127943378250299 no 494 0.149079998189279 697 24208000
SGTC_169 k015-0017 16.025 µM 1.04005457044688 0.128022273980352 no 495 0.149157274139341 681 1840002
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.03704804815833 0.128736688040176 no 496 0.149856732586895 794 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1040 k898-0338 155 µM 1.03385778829987 0.129497781656884 no 497 0.150601325599465 832 20969351
SGTC_987 1497-1013 404 µM 1.03080234599331 0.130229629442256 no 498 0.151316758955115 747 1676435
SGTC_2544 sphondin 68.51 µM 1.03070552132151 0.13025286783496 no 499 0.151339467390691 731 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_3060 1327-0027 12.5 µM 1.02878266195848 0.130714957746307 no 500 0.151790907916195 734 16000455 YPR107C YTH1
SGTC_2445 5742597 35.57 µM 1.02721710258525 0.131092019498638 no 501 0.152159123303933 729 1774255
SGTC_3029 9088683 49.47 µM 1.02158199110289 0.132455440791792 no 502 0.15348939239725 757 25236615
SGTC_2497 7-hydroxyflavone 100 µM 1.01900133744011 0.133083083536118 no 503 0.154101165790559 718 5281894
SGTC_2981 9013952 38.96 µM 1.01831137265999 0.133251236645445 no 504 0.154265002725771 705 2996344
SGTC_3200 9114385 49.47 µM 1.01549712993143 0.133938616944792 no 505 0.154934456984551 720 17018030 YLR208W SEC13
SGTC_3103 9120822 49.47 µM 1.01365134367134 0.134390772209493 no 506 0.155374574447659 810 17141819
SGTC_1455 4262-0120 131 µM 1.01308647490532 0.134529355180899 no 507 0.155509428975466 827 1529587
SGTC_457 grayanotoxin iii 135 µM 1.00905512083103 0.135521241963485 no 508 0.156474099868622 828 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1644 st010134 20.9 µM 1.00741539314643 0.135926115663839 no 509 0.156867598568157 757 3818134
SGTC_2741 miltefosine 3.04 µM 1.00336146131615 0.136930645172256 no 510 0.157843245763459 706 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2711 st079103 59.1 µM 1.00271782864872 0.13709059732204 no 511 0.157998512632685 782 54693780
SGTC_2905 7799065 20.05 µM 1.00137479592063 0.137424771595863 no 512 0.158322822236462 769 1296806
SGTC_863 0466-0191 129 µM 1.0013294525761 0.137436063653917 no 513 0.158333779163212 846 765160 YPR165W RHO1
SGTC_2261 9010538 184.68 µM 1.00109782725182 0.137493756238954 no 514 0.158389757690451 690 6457250
SGTC_2431 5490079 200 µM 0.999187235623563 0.137970271683972 no 515 0.158851999037706 808 5722345
SGTC_2441 5730946 39.09 µM 0.997742959615651 0.138331231388168 no 516 0.159202007955422 809 1774275
SGTC_597 k018-0003 82.8 µM 0.991949623327147 0.139785593031412 no 517 0.160611050210473 886 6786234
SGTC_619 1652-1634 108 µM 0.991204606231002 0.139973373996746 no 518 0.160792840914068 752 5400454
SGTC_1018 4259-0013 28.1 µM 0.9902916919109 0.140203706945862 no 519 0.161015783115296 783 6801262
SGTC_567 1080-0542 68.4 µM 0.989374834836694 0.14043529366089 no 520 0.161239891124409 759 5950415
SGTC_1492 4158-0558 28.5 µM 0.986271243758615 0.141221149070415 no 521 0.162000013477257 806 3967268
SGTC_2413 inermin 26.06 µM 0.985396952487875 0.141443064180696 no 522 0.162214563005634 839 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_615 k087-0205 167 µM 0.982912890161476 0.142074865018623 no 523 0.162825156568545 763 9642773
SGTC_2729 fluphenazine 10.66 µM 0.982470011399227 0.142187707929558 no 524 0.162934174925557 843 3372 An atypical antipsychotic.
SGTC_1414 3917-0015 5.4 µM 0.981585237423571 0.142413324728241 no 525 0.163152111604217 826 6618702
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.98154874791553 0.142422634726234 no 526 0.163161103730658 854 16623 A steroid.
SGTC_1650 st011916 45.8 µM 0.981298924293436 0.142486386227688 no 527 0.163222676532895 831 242528
SGTC_1133 3473-0247 50 µM 0.98034623405909 0.142729676601261 no 528 0.163457619973665 782 711311
SGTC_2398 5228213 48.84 µM 0.980299102389676 0.142741719994224 no 529 0.163469248838576 904 80771 YMR134W ERG29
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.974212668632576 0.144302739550004 no 530 0.164975477851343 780 17037758
SGTC_2309 7664088 163.95 µM 0.972199502318699 0.144821589876491 no 531 0.165475654061974 888 704922
SGTC_3160 9100216 49.47 µM 0.971242720290321 0.145068619731037 no 532 0.165713712481933 843 17191039
SGTC_1129 3453-1384 223 µM 0.970619453549639 0.145229692328519 no 533 0.16586890749275 865 1084452
SGTC_2048 5246248 200 µM 0.970443185576142 0.145275267583009 no 534 0.165912815704543 817 677046
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.965723302737697 0.146499203422482 no 535 0.16709132791176 817 140250 A respiratory chain inhibitor.
SGTC_1949 st076024 69.1 µM 0.965026105822232 0.146680581973286 no 536 0.167265868130513 826 2921930
SGTC_1424 4048-1941 275 µM 0.963985954463932 0.146951461474907 no 537 0.167526483865036 930 X1424
SGTC_1441 4106-0040 13 µM 0.963152539069957 0.147168744095405 no 538 0.167735489415359 847 2904180
SGTC_3294 9122953 26.2835 µM 0.962141277663605 0.147432682653086 no 539 0.16798932091924 846 16459826
SGTC_1571 st070080 73.4 µM 0.960858840418688 0.147767853819021 no 540 0.168311574232645 844 4315245
SGTC_607 4491-0986 66.8 µM 0.957218986263555 0.148721924624284 no 541 0.169228367952993 881 698981 YDR232W HEM1
SGTC_230 MPP+ 141.667 µM 0.957070034162303 0.148761055129666 no 542 0.169265953644997 805 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_847 0342-0274 5.54 µM 0.953975917890417 0.149575451948307 no 543 0.170047916284213 891 18097
SGTC_710 3448-4187 58 µM 0.952246229736794 0.150032014169472 no 544 0.170486060234098 916 3946412
SGTC_128 0906-2981 13.371 µM 0.95121683945514 0.150304168878395 no 545 0.170747155919808 788 6740226
SGTC_3063 1327-0034 4 µM 0.950441377483762 0.150509406040062 no 546 0.170944013871549 830 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_104 0074-0074 590.992 µM 0.947679070578207 0.151242006536167 no 547 0.171646429453364 712 3943124
SGTC_1587 estradiol valerate 56.1 µM 0.9474676771495 0.151298168425939 no 548 0.171700259661843 877 13791 A steroid.
SGTC_3332 9141069 11.198 µM 0.946600014992587 0.151528829618257 no 549 0.171921318152367 791 17332883
SGTC_778 3456-2434 196 µM 0.946520663612414 0.151549936223456 no 550 0.171941543953418 958 5539063
SGTC_2129 girgensonine 121.053 µM 0.945978421443459 0.15169421905926 no 551 0.172079796225518 897 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.945740314526165 0.151757604719091 no 552 0.172140527348411 879 165521
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.944701599486101 0.152034323474372 no 553 0.172405620113867 862 6312947
SGTC_3101 9120531 49.47 µM 0.943845770363834 0.152262572187002 no 554 0.172624233716548 868 24824904
SGTC_2492 derrusnin 100 µM 0.939978578482812 0.153296783334897 no 555 0.17361427439818 781 1715307 Part of coumarin class of compounds.
SGTC_2138 5575593 77.673 µM 0.936312061279406 0.154281616045282 no 556 0.174556269974591 860 762213
SGTC_41 0478-0632 82.643 µM 0.935504304486957 0.154499142052848 no 557 0.174764233023365 950 3750424
SGTC_2367 9070478 135.38 µM 0.935229153731372 0.154573285432753 no 558 0.174835108547486 851 572802
SGTC_1138 3761-0006 1.03 µM 0.93381190261482 0.154955556858462 no 559 0.175200464316482 877 12061087
SGTC_2229 7354935 190 µM 0.933781049402751 0.154963885752554 no 560 0.17520842340433 833 318112
SGTC_1997 st073024 93.8 µM 0.932028545381493 0.155437463511581 no 561 0.17566088671714 876 686268
SGTC_247 mechlorethamine 29.705 µM 0.931635457563255 0.155543818298254 no 562 0.17576247610398 829 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_499 genistein 192 µM 0.931387916567612 0.155610818214343 no 563 0.175826469549358 869 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2516 gossypol 71.55 µM 0.931374601329589 0.155614422681386 no 564 0.175829912177028 905 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1102 cgs 12066b 26.1 µM 0.930365081459691 0.155887862508968 no 565 0.176091045802367 843 6438352 A 5-HT1B full agonist.
SGTC_2518 prenyletin 46.28 µM 0.929694000186923 0.156069807589976 no 566 0.176264770915837 786 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1996 st072960 66.8 µM 0.928139810821375 0.156491720091554 no 567 0.176667525548547 905 1719405
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.927642379313558 0.156626915277061 no 568 0.176796553414684 908 688798
SGTC_941 3237-0776 460 µM 0.927036134120396 0.15679178848012 no 569 0.176953886784617 862 760008
SGTC_1989 st071868 50.2 µM 0.925472479011181 0.157217563924962 no 570 0.177360096395968 910 16414057
SGTC_69 0096-0274 206.684 µM 0.924961019163138 0.157356996726581 no 571 0.177493092193829 931 6741392
SGTC_1158 4092-0494 91.8 µM 0.924761528734921 0.157411403297323 no 572 0.177544983098875 920 1148199
SGTC_2982 9019404 25.97 µM 0.923871002829564 0.157654425174296 no 573 0.177776741018151 781 22333232
SGTC_1113 artemisinin 1.17947 µM 0.923771814596031 0.157681508596924 no 574 0.177802566401598 918 2240 An anti-malaria and mitochondrial poison.
SGTC_3081 9117243 49.47 µM 0.922710244084407 0.157971562630767 no 575 0.178079112952939 887 45595589
SGTC_2999 9069765 71.4286 µM 0.921412645019278 0.158326582494063 no 576 0.178417514691537 898 2097066
SGTC_3315 9136395 68.55 µM 0.919601525451154 0.158822974825475 no 577 0.178890514639232 946 16876844
SGTC_2341 7987486 176.74 µM 0.918594931270446 0.159099303094996 no 578 0.179153742091711 921 1258686
SGTC_280 3448-3607 3.04 µM 0.918053979510088 0.159247934149185 no 579 0.179295303226184 917 626179
SGTC_1450 4112-4260 37.6 µM 0.917885928046257 0.159294126212064 no 580 0.179339294764896 923 1633175
SGTC_1715 st032160 10.2275 µM 0.91397405615408 0.160371855811225 no 581 0.180365239102179 861 5289825
SGTC_2462 5162487 171.77 µM 0.912774087264798 0.160703402727481 no 582 0.180680684710653 918 2259986
SGTC_3073 9114972 49.47 µM 0.912584193849608 0.160755910560545 no 583 0.180730635224977 824 41905075
SGTC_2458 5808907 16.39 µM 0.910977257635224 0.161200696376412 no 584 0.181153678329299 972 2731747
SGTC_1097 itavastatin 7.23 µM 0.910885635179326 0.161226080837523 no 585 0.181177817595319 918 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1270 0831-1170 17.3 µM 0.908616031834868 0.161855718137957 no 586 0.181776420529624 953 6764716
SGTC_827 3253-0474 693 µM 0.908184771399149 0.161975540052011 no 587 0.181890304256411 945 5402065
SGTC_549 1661-1316 519 µM 0.907579478048888 0.162143812916708 no 588 0.182050220420728 946 2857282
SGTC_3224 9130643 49.47 µM 0.907129779019285 0.162268903900193 no 589 0.182169086061994 866 17644395
SGTC_1854 st056233 32.9 µM 0.906557996545594 0.16242804504995 no 590 0.182320291159112 879 5393174
SGTC_184 1494-0393 24.714 µM 0.90602330154548 0.162576955716958 no 591 0.182461759589512 885 3090647
SGTC_298 1391-0729 10 µM 0.904814353419359 0.162913970837194 no 592 0.182781873138199 893 3237558
SGTC_3187 9109394 49.47 µM 0.902122836631126 0.163665907652734 no 593 0.183495809504626 893 17098090
SGTC_2206 7254556 146.969 µM 0.899848833924203 0.164302955534649 no 594 0.184100351145948 919 4398905
SGTC_164 4100-3994 89.624 µM 0.892246711420507 0.166444297986418 no 595 0.18613035495986 977 4615967
SGTC_2797 7859098 81.82 µM 0.891291652394807 0.16671458441772 no 596 0.186386362901928 903 972681
SGTC_2695 st077686 51.995 µM 0.890879233033881 0.166831388645816 no 597 0.186496981201232 882 2876092
SGTC_257 daunorubicin 18.5 µM 0.889738410218372 0.167154764136807 no 598 0.18680318215732 925 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_459 nigericin 15.3 µM 0.889102348572818 0.167335236320025 no 599 0.186974038421596 990 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2772 vinpocetine 57.06 µM 0.888325998193278 0.167555683265468 no 600 0.187182709444517 893 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1984 st072354 53.1 µM 0.888105125587275 0.167618434851525 no 601 0.187242102904325 918 5762938
SGTC_1561 5-methoxyflavone 52.9 µM 0.887524419692876 0.167783490014832 no 602 0.187398312450622 905 94525
SGTC_2929 9013348 24.6 µM 0.88706643091933 0.167913738842023 no 603 0.187521567964708 884 2995952
SGTC_1750 st081859 2.357 µM 0.885411322856884 0.168384982536361 no 604 0.187967413852419 1039 5291695
SGTC_832 4083-0019 164 µM 0.883589075390429 0.168904796998113 no 605 0.188459039243126 1083 1990758
SGTC_2745 rifampicin 24.3 µM 0.88344865619874 0.168944895723875 no 606 0.188496955912809 806 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_368 fentichlor 4.58 µM 0.881735479438926 0.169434610420919 no 607 0.188959934933306 854 7329 A pesticide.
SGTC_1794 st048918 76.9 µM 0.881253122669988 0.169572657169621 no 608 0.189090416163699 870 672303
SGTC_2448 5185112 27.17 µM 0.880499909227672 0.169788365257268 no 609 0.189294277163257 840 5718189
SGTC_537 1334-0398 209 µM 0.878628238914212 0.170325142734897 no 610 0.189801439671077 972 5846986
SGTC_2839 9003951 25.97 µM 0.878228658701213 0.170439879247421 no 611 0.18990982120508 926 2990634
SGTC_1643 st009866 20.2 µM 0.875977737805435 0.171087139099379 no 612 0.190521068188928 945 3156273 YOR207C RET1
SGTC_986 1493-0483 84 µM 0.875478509599057 0.171230906573421 no 613 0.190656799178589 918 40079
SGTC_687 k029-0044 34.9 µM 0.874317306060154 0.171565608052447 no 614 0.190972738621488 994 5829338
SGTC_2991 9074669 71.4286 µM 0.873740398642022 0.171732049272613 no 615 0.191129822519669 971 17333109
SGTC_2564 betulinic acid 100 µM 0.872560171166086 0.172072873124486 no 616 0.191451428849072 998 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2184 6075246 200 µM 0.871365038722239 0.172418440855299 no 617 0.191777434380964 922 2267320
SGTC_848 0368-0089 85.6 µM 0.870377913591623 0.172704197672997 no 618 0.19204695629565 964 762535
SGTC_2390 9097792 176.6 µM 0.870357637724924 0.172710070372232 no 619 0.192052494790524 895 4497149
SGTC_2820 7989630 71.43 µM 0.870044102681832 0.172800898822822 no 620 0.192138151522691 837 2984098
SGTC_3090 9117696 49.47 µM 0.865276094329348 0.174185900824658 no 621 0.193443634266422 928 7923821
SGTC_113 0099-0221 2.5 µM 0.864211291179059 0.174496163892972 no 622 0.19373591532054 915 89219
SGTC_1008 4106-0037 6 µM 0.860013851487084 0.175722632998386 no 623 0.194890703551957 969 2905394
SGTC_757 1066-0008 322 µM 0.858919197812797 0.176043380554186 no 624 0.195192548483347 984 6842497
SGTC_1988 st071872 53.4 µM 0.858698489256276 0.176108095863553 no 625 0.195253442092782 981 16414116
SGTC_1015 4130-4525 82 µM 0.857880103101082 0.176348191315572 no 626 0.195479336010638 952 1363237
SGTC_617 3770-0098 35 µM 0.857711205203582 0.176397767798002 no 627 0.195525975572589 917 5962639
SGTC_908 3448-7491 47.7 µM 0.85723349192033 0.176538038379391 no 628 0.195657928173844 1004 1203031
SGTC_564 3555-0129 330 µM 0.856748060656923 0.176680647429737 no 629 0.195792067977587 880 563260
SGTC_429 1112-0049 25.5 µM 0.853672555737952 0.17758585513649 no 630 0.196643222247901 890 2836170
SGTC_2850 9015429 58.44 µM 0.852404105506117 0.177960046746705 no 631 0.196994921142405 936 6457570
SGTC_3064 1327-0027 10 µM 0.85181011456048 0.178135444314285 no 632 0.197159745807893 842 16000455 YPR107C YTH1
SGTC_883 0850-0245 24.6 µM 0.849878884234748 0.178706463536666 no 633 0.197696213207933 994 6823229 YPR165W RHO1
SGTC_534 k292-0788 63.4 µM 0.849814870619177 0.178725410564012 no 634 0.19771401034158 1047 4146317
SGTC_921 1561-0023 372 µM 0.849563699547179 0.178799765482702 no 635 0.197783850542905 1023 24050882
SGTC_359 0081-0058 15.9 µM 0.846028907496182 0.179848245092699 no 636 0.198768309083551 910 3494159
SGTC_3337 9144342 33.5465 µM 0.844593165221284 0.18027521134342 no 637 0.199169013214684 979 17682949
SGTC_713 1488-1073 324 µM 0.842930551680187 0.180770439508202 no 638 0.199633642783692 1003 3312542
SGTC_874 0599-0792 117 µM 0.842418915994712 0.18092300740252 no 639 0.199776754266999 1046 765305
SGTC_1540 guanosine 70.6 µM 0.839968229152902 0.181654911767214 no 640 0.200463100139648 943 6802 Guanosine is a purine nucleoside
SGTC_3182 9108849 49.47 µM 0.83852999838259 0.182085304799448 no 641 0.20086655350645 1038 17133045
SGTC_3085 9117376 49.47 µM 0.835155698530764 0.183097569624378 no 642 0.201815024757101 988 16480349
SGTC_408 cantharidin 100 µM 0.835072060848266 0.183122704810977 no 643 0.201838568216204 983 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1178 0988-0033 191 µM 0.834349074365518 0.183340069794233 no 644 0.202042152709723 992 5392207
SGTC_1742 st038235 28.8875 µM 0.83429788949286 0.18335546455764 no 645 0.202056570424783 960 564103 YBR002C RER2
SGTC_546 peri-Naphthalide 147 µM 0.834030472693896 0.183435908034239 no 646 0.202131906191484 987 223824 A penicillin ester.
SGTC_2757 clomiphene 4.22 µM 0.833883484084398 0.183480134052047 no 647 0.202173322488164 1066 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_3214 9129694 49.47 µM 0.833101092557435 0.183715652294025 no 648 0.202393858731617 958 17158655
SGTC_2725 haloperidol 53.21 µM 0.830922848701092 0.184372346449946 no 649 0.203008607518023 1004 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_635 k038-0028 24.7 µM 0.828901111471957 0.184983162223324 no 650 0.203580183200164 991 4035102
SGTC_3017 9080681 49.47 µM 0.828812401091196 0.185009992541367 no 651 0.203605284926452 974 16451914
SGTC_2193 5925765 200 µM 0.82508778303881 0.186138678626891 no 652 0.204660877580895 996 877370
SGTC_1445 4239-0156 97.7 µM 0.824468726950938 0.186326686473004 no 653 0.204836639044577 1079 4008346
SGTC_2187 6125751 200 µM 0.824328978125165 0.186369144578849 no 654 0.204876328734018 985 874498
SGTC_1963 st076565 50.3 µM 0.824300074640747 0.186377926704342 no 655 0.204884538105814 1000 4914280
SGTC_2581 avocatin a 64 µM 0.824007404284734 0.186466867024705 no 656 0.204967675424554 990 6710728 A skin care supplement.
SGTC_17 0960-0276 49.807 µM 0.822643446667188 0.186881710123081 no 657 0.205355392090108 1063 6821114
SGTC_1078 idebenone 36.1 µM 0.822233673357098 0.187006452770605 no 658 0.20547195871262 1033 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1473 k844-0725 134 µM 0.821882793974433 0.187113307935765 no 659 0.205571803227089 1112 54682906
SGTC_1840 st055363 71 µM 0.820893467503202 0.187414796085589 no 660 0.205853476164764 931 676033
SGTC_2780 5215298 71.43 µM 0.820867271234384 0.187422783236195 no 661 0.205860937662519 1039 2834131
SGTC_2272 7805186 180 µM 0.820142132804765 0.187643958915788 no 662 0.20606754292964 1007 2956062 YPR165W RHO1
SGTC_2909 7941780 10.49 µM 0.820116553475747 0.187651763852795 no 663 0.206074833195118 1023 1243215
SGTC_3309 9129340 25.759 µM 0.81744433380896 0.188468234116018 no 664 0.206837274404596 1045 17158987
SGTC_3320 9137005 35.139 µM 0.817425321900713 0.188474050854212 no 665 0.206842704882547 937 4908713
SGTC_35 0133-0054 64.071 µM 0.814290677535694 0.189434616205827 no 666 0.207739224520995 990 99677
SGTC_251 melphalan 456.522 µM 0.81161050767203 0.190258299298758 no 667 0.208507579997236 1119 460612 A DNA alkylator.
SGTC_2701 st077767 14.721 µM 0.810922238142417 0.190470176232376 no 668 0.208705164314387 1039 5721188
SGTC_2754 granisetron 64.02 µM 0.807964277385141 0.191382403312949 no 669 0.209555573411026 1006 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1221 2958-7315 257 µM 0.807113955510057 0.191645134931191 no 670 0.209800416290951 1014 4562705
SGTC_481 bay k-8644 50 µM 0.805375419624263 0.192182993165615 no 671 0.210301535877173 969 2303 A calcium channel antagonist.
SGTC_1262 0737-0114 49.6 µM 0.805128514300519 0.192259454131955 no 672 0.210372761388487 1086 765919
SGTC_3124 9127567 49.47 µM 0.804688583638649 0.192395736761989 no 673 0.210499704583837 995 17592030
SGTC_2897 9048598 12.99 µM 0.804533603439466 0.192443760915224 no 674 0.210544435250526 1029 6467404
SGTC_248 streptozotocin 5.23457 mM 0.801115610039703 0.193504766632816 no 675 0.21153236002121 1082 5300 DNA alkylating agent.
SGTC_1939 st074455 53.6 µM 0.799793571323392 0.193916106027874 no 676 0.211915204164932 1029 1644229
SGTC_1231 0242-0792 125 µM 0.799359083629605 0.194051408877745 no 677 0.212041114236426 1027 3707635
SGTC_482 fipronil 114 µM 0.799155192897278 0.194114921862393 no 678 0.21210021475531 1041 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2708 st078559 56 µM 0.796657751163252 0.194893914606006 no 679 0.212824913601393 948 17250902
SGTC_2141 5621638 7.665 µM 0.794375325686507 0.195607500319065 no 680 0.213488482087398 1050 2856238
SGTC_99 0109-0120 622.8 µM 0.792076179604355 0.19632791514292 no 681 0.214158129217495 1037 759414
SGTC_2887 9044784 58.44 µM 0.791573177749457 0.196485739996745 no 682 0.214304795843315 1111 6465546
SGTC_747 3448-8087 38.7 µM 0.790389241097898 0.196857522331623 no 683 0.214650241768213 1046 5168703
SGTC_3305 9127027 53.8275 µM 0.790046906928939 0.196965102178536 no 684 0.214750187416884 1031 41905295
SGTC_68 0986-0284 82.829 µM 0.789267263727869 0.197210240875404 no 685 0.214977907844423 893 423278 YIL048W NEO1
SGTC_959 1222-0044 107 µM 0.789155024212296 0.197245546889475 no 686 0.215010702628199 1063 6083612
SGTC_170 4197-0004 226 µM 0.788721525177794 0.197381944060804 no 687 0.215137392130889 995 218692
SGTC_95 0471-0001 561.058 µM 0.786846230109141 0.197972648204987 no 688 0.215685943532421 1035 4015405
SGTC_2215 7188065 200 µM 0.786716106829539 0.198013675655696 no 689 0.215724036567867 1062 940217
SGTC_2560 caryophyllene 100 µM 0.784535412509925 0.198702005381135 no 690 0.216363005653637 1146 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1691 st019933 84.6 µM 0.78320620852181 0.199122271544391 no 691 0.216753014823566 1060 6176082
SGTC_1928 4'-methoxychalcone 40.3 µM 0.781824792234736 0.199559613104873 no 692 0.217158774367836 1106 641818
SGTC_3072 9116419 49.47 µM 0.781704711531319 0.199597656656309 no 693 0.217194066055107 1050 17170162
SGTC_2092 5303694 80.6725 µM 0.777744529730862 0.200854751728852 no 694 0.218359817506843 1044 1963699
SGTC_1999 st074831 12.5 µM 0.774158740836972 0.201997090361075 no 695 0.219418461976343 1045 17112523
SGTC_72 0744-0168 198.391 µM 0.77369226061037 0.202145984085543 no 696 0.219556398934455 1024 677577
SGTC_395 anisomycin 6.25 µM 0.773485419863884 0.202212025661338 no 697 0.219617577125818 997 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_309 k408-0051 1.48 µM 0.771678648072798 0.202789453150114 no 698 0.220152389992273 1087 3640463
SGTC_3306 9127676 59.7925 µM 0.771349035881652 0.202894900298976 no 699 0.22025003723746 1073 41905287
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.770892369741678 0.203041047737179 no 700 0.220385365103437 1058 688667
SGTC_509 pifithrin 175 µM 0.769501003144107 0.203486715892414 no 701 0.220797974623176 1131 4817 A p53 inhibitor.
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.76892797025418 0.203670433379265 no 702 0.220968035949066 1031 689007
SGTC_2565 isoliquiritigenin 100 µM 0.767507094276951 0.204126400453139 no 703 0.221390038428583 998 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_358 0075-0058 9.45 µM 0.764637642658238 0.205049075340697 no 704 0.222243673772696 1109 1069125
SGTC_1897 st060201 15 µM 0.763552876825092 0.205398527514062 no 705 0.222566870139128 1049 611878
SGTC_312 4092-0653 6.84 µM 0.763044022753623 0.205562574242311 no 706 0.222718570987608 1124 1148278
SGTC_2259 7964009 200 µM 0.758328603569494 0.207086449507849 no 707 0.224127143880893 1055 313134
SGTC_1775 st081588 35.1725 µM 0.757575164773243 0.207330554991327 no 708 0.224352676255377 1153 1426443 YGL099W LSG1
SGTC_83 0170-0301 39.027 µM 0.756364991658388 0.207722993024444 no 709 0.224715195763939 1056 3089716
SGTC_1459 k035-0031 35.7 µM 0.755935928743647 0.207862235942137 no 710 0.224843805596435 981 3877128 YMR208W ERG12
SGTC_3007 9078383 71.4286 µM 0.755477032340399 0.208011221646485 no 711 0.224981404066162 1104 6496995
SGTC_2357 9067248 200 µM 0.7536423165403 0.208607511603374 no 712 0.225532013720304 1084 9150235
SGTC_3131 9127911 49.47 µM 0.753012200125548 0.208812534193028 no 713 0.225721291386112 1107 45595681
SGTC_949 1165-0505 146 µM 0.752972935439966 0.208825313772759 no 714 0.225733088891395 1123 6244267
SGTC_2386 9075165 157.42 µM 0.750634802059357 0.209587142607617 no 715 0.226436235226819 1095 16452277
SGTC_1103 duloxetine 36.1 µM 0.749321880297716 0.210015644728942 no 716 0.226831611524709 1181 60835 A selective serotonin reuptake inhibitor.
SGTC_2301 7769476 200 µM 0.749202807840426 0.210054532199001 no 717 0.226867488532149 1086 977820
SGTC_2066 5222451 176 µM 0.745558528437015 0.211246749828527 no 718 0.227967071450044 1159 2281147
SGTC_2561 acetosyringone 100 µM 0.745165773434179 0.211375474959681 no 719 0.228085755522679 1158 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_60 0986-0278 202 µM 0.744703899954144 0.211526912382206 no 720 0.22822537050506 978 3110598
SGTC_2915 7971052 15.16 µM 0.743688286894299 0.211860131285318 no 721 0.228532538632441 1004 5741558
SGTC_1035 k081-0041 55.2 µM 0.741589420616461 0.212549733882468 no 722 0.229168067656723 1152 731709
SGTC_3058 9093861 49.47 µM 0.741129782336978 0.212700927248 no 723 0.229307376625688 1123 17217477
SGTC_2493 resveratrol 26.09 µM 0.740743518919552 0.212828033240019 no 724 0.229424483558043 1066 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1137 ixabepilone 100 µM 0.740617192617725 0.212869612495825 no 725 0.229462790304496 1118 154225 A novel microtubule stabilizer.
SGTC_844 0330-0132 15.3 µM 0.740369359292717 0.212951198554928 no 726 0.229537952829078 1146 2828079
SGTC_1809 st050081 57.6 µM 0.73921817674558 0.213330403879067 no 727 0.229887262566042 1162 5036894
SGTC_1465 k213-0056 144 µM 0.737629929997689 0.213854226082923 no 728 0.23036968125691 1056 24048857 YMR208W ERG12
SGTC_2334 9017922 200 µM 0.736468049953372 0.214237901505801 no 729 0.230722952280405 1140 3163164
SGTC_1184 1269-1718 139 µM 0.735779451504536 0.214465478996569 no 730 0.230932464207256 1147 5403821
SGTC_1611 st001856 99.4 µM 0.734990304426256 0.214726459950917 no 731 0.231172699471286 1116 647478
SGTC_385 1494-0393 12.4 µM 0.734913061269623 0.214752015155144 no 732 0.231196221627702 1112 3090647
SGTC_58 0957-0393 9 µM 0.733965594503422 0.215065619771233 no 733 0.231484853693274 1133 6997992
SGTC_398 bronopol 33.3 µM 0.733931565917503 0.215076887930136 no 734 0.231495223746359 1099 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_3069 9117009 49.47 µM 0.732329721440414 0.215607707284831 no 735 0.231983671341893 1022 41904981
SGTC_2036 5160441 105 µM 0.731550881870962 0.215866073437922 no 736 0.232221368693583 1146 134534 YIL048W NEO1
SGTC_2770 toltrazuril 17.5 µM 0.731289583854135 0.215952794578125 no 737 0.232301145695773 1137 68591 Kills coccidiodes.
SGTC_686 1319-0111 510 µM 0.730068912969818 0.21635818540359 no 738 0.232674031138192 1174 4562600
SGTC_3047 9092122 49.47 µM 0.729632216796234 0.216503321269493 no 739 0.232807512017028 1131 17173831
SGTC_2391 6285546 200 µM 0.72813014871389 0.21700296314532 no 740 0.233266959981938 1132 846083
SGTC_1084 voriconazole 435 nM 0.725197011992045 0.217980548690437 no 741 0.234165587842904 1167 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2865 9030313 51.95 µM 0.725156000923827 0.217994235250195 no 742 0.234178166015408 1103 42562754
SGTC_1105 epirubicin 18.1 µM 0.723688155444446 0.218484423144417 no 743 0.234628603228086 1128 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2647 atorvastatin 60.16 µM 0.721635857906862 0.219170852189996 no 744 0.235259193543717 1120 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2081 5214970 32.255 µM 0.721133544153901 0.219339049030115 no 745 0.235413677222015 1117 2063512
SGTC_9 0092-0002 10.449 µM 0.721040881404258 0.219370084715098 no 746 0.235442181227949 1147 759368
SGTC_3028 9087778 49.47 µM 0.72024383814593 0.219637143888283 no 747 0.235687438488447 1132 17217395
SGTC_2614 arthonioic acid 13.39 µM 0.718816125988613 0.220115982888793 no 748 0.236127110174515 1127 6710684
SGTC_568 1193-0097 7.48 µM 0.718658630429282 0.220168841817577 no 749 0.236175639439612 1084 3646150
SGTC_1190 1486-1332 13 µM 0.71832553747447 0.22028065902066 no 750 0.236278293800107 1153 4150046
SGTC_2986 9022445 71.43 µM 0.717463815254635 0.220570084758195 no 751 0.236543977907422 1133 6459286
SGTC_3173 9105693 49.47 µM 0.717393507153513 0.220593708676019 no 752 0.236565662382133 1209 17096658
SGTC_2920 7982904 15.77 µM 0.71729700387004 0.220626136682818 no 753 0.236595427774605 1118 6456808
SGTC_1753 st043925 64 µM 0.71562328051294 0.221188992337084 no 754 0.237111997265338 1180 670181
SGTC_852 0418-0143 439 µM 0.714195919608732 0.221669647202113 no 755 0.237553019835574 1205 5369229
SGTC_2037 5169046 200 µM 0.71418997537083 0.221671650134203 no 756 0.237554857412865 1158 5718022
SGTC_228 caffeine 993.056 µM 0.714141727922282 0.221687907666088 no 757 0.237569772719573 1159 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_66 0109-0187 42.4 µM 0.713257636995486 0.221985932852643 no 758 0.237843173218219 1123 759417
SGTC_2125 5246583 200 µM 0.71238264584078 0.22228111563276 no 759 0.238113929463307 1208 835267
SGTC_2006 4011487 200 µM 0.712334356799446 0.22229741270809 no 760 0.238128876884612 1192 45595294
SGTC_677 0929-0063 136 µM 0.712232010273452 0.22233195590495 no 761 0.238160558994632 1125 1539583
SGTC_320 4092-0846 5.34 µM 0.712171824662789 0.222352270710045 no 762 0.238179190965692 1149 1359356
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.711453026578418 0.222594972703338 no 763 0.23840177472596 1231 5393153
SGTC_397 arbidol 50 µM 0.711369484879259 0.222623190330593 no 764 0.238427651721672 1194 131410 A RNA synthesis inhibitor.
SGTC_462 ag-879 158 µM 0.710162745912158 0.223031014304923 no 765 0.238801609961595 1185 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2899 9053889 58.44 µM 0.71013377425978 0.223040810659016 no 766 0.238810591974746 1147 6470052
SGTC_2921 7974240 10.71 µM 0.709895799191306 0.223121287831874 no 767 0.238884377817516 1163 2979074 YDR527W RBA50
SGTC_2810 7959871 45.46 µM 0.709299479104809 0.223323020866468 no 768 0.239069325804753 1184 2974535
SGTC_1206 3978-0017 132 µM 0.708831953789632 0.223481255638234 no 769 0.23921438296372 1190 3873677
SGTC_57 miconazole 162.5 nM 0.707730244579402 0.223854383191639 no 770 0.239556395866641 1126 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_689 0833-0039 98 µM 0.706681862999725 0.224209778248841 no 771 0.239882101544202 1182 5374726
SGTC_1674 st016616 23.6 µM 0.702162444061633 0.225745496481963 no 772 0.241288931879775 1184 625830
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.701681215906639 0.225909369695787 no 773 0.241438994972908 1205 688669
SGTC_3149 9097855 49.47 µM 0.701107564144232 0.226104803887561 no 774 0.24161794506309 1176 25236625 YMR079W SEC14
SGTC_386 1509-0011 3.07 µM 0.700910870840945 0.226171836214514 no 775 0.241679319915658 1226 3107280
SGTC_3344 9148862 3.898 µM 0.700734572997977 0.226231927388568 no 776 0.241734337897627 1215 4905352
SGTC_587 k089-0003 57 µM 0.700298804777248 0.22638049781771 no 777 0.241870359014557 1133 9659696
SGTC_488 nitrendipine 139 µM 0.700130043524251 0.226438049928246 no 778 0.241923047469394 1212 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1622 st003707 19.4 µM 0.699892597861479 0.226519039252221 no 779 0.241997190223916 1196 10140899
SGTC_1993 st073995 70.8 µM 0.699203345400169 0.226754226036464 no 780 0.242212480103097 1187 3098394
SGTC_3261 9137475 49.47 µM 0.698571213118103 0.226970043342402 no 781 0.242410019575182 1062 17027690
SGTC_2808 7946468 45.46 µM 0.697469254792759 0.227346541551821 no 782 0.242754586896576 1184 2970879
SGTC_1071 trifluoperazine 6.31 µM 0.697009932163563 0.227503578866097 no 783 0.242898289052499 1227 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_660 4031-1742 102 µM 0.696912989837047 0.227536730178273 no 784 0.242928623988669 1127 6738706
SGTC_1199 1638-0010 4.46 µM 0.694779724484819 0.228266929952536 no 785 0.243596678254581 1186 3111136
SGTC_1986 st071812 45 µM 0.692720366776457 0.228973079529652 no 786 0.244242527579449 1145 11838594
SGTC_3133 9127736 49.47 µM 0.69015365728786 0.229854912364092 no 787 0.245048781520021 1214 27243420
SGTC_54 0159-0055 9 µM 0.689828631135064 0.22996671560769 no 788 0.245150980656068 1235 3319099
SGTC_2823 7987624 58.44 µM 0.689458659842668 0.230094016216925 no 789 0.245267339942295 1231 2239440
SGTC_2837 9008476 45.46 µM 0.688803657502863 0.230319487654914 no 790 0.24547341683987 1235 2992805
SGTC_777 1315-0167 517 µM 0.688595642145031 0.230391118616064 no 791 0.245538882109981 1179 4221767
SGTC_3265 9137266 49.47 µM 0.68723233022605 0.230860888981946 no 792 0.245968167032145 1163 17224265
SGTC_458 nppb 133 µM 0.68397271722852 0.231986252672221 no 793 0.246996196979038 1243 4549 A chloride channel blocker.
SGTC_1243 0416-0003 5.65 µM 0.6839422860814 0.231996773231999 no 794 0.247005805297166 1212 2141977
SGTC_2831 7999036 19.48 µM 0.683882576711028 0.23201741653833 no 795 0.247024658490846 1214 2988270
SGTC_2 0422-0095 29 µM 0.682169291507321 0.232610185716975 no 796 0.247565954979215 1116 6790840
SGTC_2507 purpurin 79.67 µM 0.681710159311647 0.232769181007027 no 797 0.247711121099552 1208 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_404 fumagillin 50 µM 0.681339014417379 0.232897750842052 no 798 0.247828501050756 1204 12015870 A methionine aminopeptidase binder.
SGTC_1937 st074714 47.2 µM 0.68117917099661 0.232953135012612 no 799 0.247879062995158 1192 17250970
SGTC_51 1013-0126 23.419 µM 0.679491044506464 0.233538500594195 no 800 0.248413390032437 1305 1627850
SGTC_2944 9067346 25.62 µM 0.677855984238649 0.234106242053743 no 801 0.248931505164823 1171 6473075
SGTC_2946 9065502 71.43 µM 0.677354104575745 0.234280662757943 no 802 0.249090655226082 1061 16489101
SGTC_1728 st035614 33.7865 µM 0.675927626547161 0.234776806229849 no 803 0.249543298236606 1213 15945546
SGTC_2383 9036125 200 µM 0.674912688766091 0.235130165201998 no 804 0.249865619202937 1181 79580
SGTC_415 dibenzyl ketone 100 µM 0.672291428649341 0.236044136064097 no 805 0.250699092684047 1224 7593
SGTC_2190 6049624 200 µM 0.671887948252131 0.236184993692461 no 806 0.250827516658797 1172 2265554
SGTC_872 0588-0139 234 µM 0.671240360272288 0.236411167617453 no 807 0.251033710542897 1255 2047100
SGTC_1755 st041960 45.185 µM 0.670135255340787 0.236797407212646 no 808 0.251385786148475 1239 2257073
SGTC_2191 5911152 200 µM 0.669636160381468 0.236971957030921 no 809 0.251544878427828 1236 2875902
SGTC_396 dithiazanine 1.25 µM 0.669602140695163 0.236983857401071 no 810 0.251555724531744 1215 10578 An antihelmenthic.
SGTC_935 2996-0153 430 µM 0.669398957765966 0.237054939324144 no 811 0.251620508144088 1241 23738523
SGTC_1412 3909-8563 178 µM 0.668058668483413 0.237524122242152 no 812 0.252048071750747 1297 23767530
SGTC_384 k007-0144 5.16 µM 0.665968736519205 0.238256741682089 no 813 0.252715541798861 1244 6824886
SGTC_1951 sophoraflavanone G 9.2 µM 0.66456834962615 0.238748334922561 no 814 0.253163309302966 1258 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_465 cgp-37157 41 µM 0.663809910332048 0.239014809701155 no 815 0.253405990980273 1175 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2480 5767542 37.17 µM 0.66333673733925 0.239181139573911 no 816 0.253557456459705 1255 2867358
SGTC_1452 4194-0072 190 µM 0.662527051941247 0.239465907025581 no 817 0.25381675184036 1283 1343545
SGTC_2465 5809242 33.21 µM 0.661909482744668 0.239683231343246 no 818 0.254014617054562 1246 2731748
SGTC_2052 5265182 7.135 µM 0.661258104552659 0.239912569727391 no 819 0.254223402116807 1251 1239884
SGTC_109 0132-0036 33.701 µM 0.660754699282052 0.240089891501011 no 820 0.254384819311018 1147 67274 A color developer.
SGTC_2397 5161689 200 µM 0.656789785262942 0.241489005231521 no 821 0.255658046578041 1321 2259942
SGTC_3205 9113483 49.47 µM 0.656155231481522 0.241713332889419 no 822 0.255862125221269 1251 17018033
SGTC_695 3505-6186 243 µM 0.655105128817991 0.242084813860005 no 823 0.25620003508589 1273 1819379
SGTC_1861 st057647 17.4 µM 0.654975259549151 0.242130777499643 no 824 0.256241841549465 1320 688668
SGTC_2819 7996655 46.38 µM 0.654127364543095 0.242430982767378 no 825 0.256514876429888 1165 6456960
SGTC_2479 5617353 43.85 µM 0.652278668981613 0.243086229485437 no 826 0.257110709093604 1309 2731746
SGTC_3147 9097027 49.47 µM 0.651031210632139 0.243528915886826 no 827 0.257513169929127 1292 25236841
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.651002618953334 0.243539067337655 no 828 0.257522398144506 1249 97141
SGTC_2738 aclarubicin 5.55 µM 0.650371807694537 0.243763094467704 no 829 0.257726041709618 1192 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1966 st070145 16.1 µM 0.64926993033647 0.244154683340842 no 830 0.258081959062781 1208 3748532
SGTC_103 0844-0104 51.839 µM 0.647581116569591 0.244755517407465 no 831 0.258627957010271 1303 5375804
SGTC_2761 levamisole 97.89 µM 0.647349566127927 0.244837958771002 no 832 0.25870286447302 1306 26879 An alkaline phosphatase inhibitor.
SGTC_764 1951-2361 146 µM 0.646995927467604 0.24496389733879 no 833 0.258817289616441 1244 5438930
SGTC_1749 st037932 54.2 µM 0.64645385839265 0.245157007794859 no 834 0.258992735099006 1266 594497
SGTC_2790 5423970 71.43 µM 0.646078242920992 0.245290867664048 no 835 0.25911434245944 1308 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_3273 9137859 49.47 µM 0.644208671763756 0.245957719690419 no 836 0.259720064194393 1336 2377234
SGTC_1006 4099-6547 255 µM 0.64395716231432 0.246047504059294 no 837 0.259801606390049 1291 3146833
SGTC_1288 0973-0013 65.5 µM 0.643561631552742 0.246188737016735 no 838 0.259929868633571 1315 4315430
SGTC_1792 st045773 43.6 µM 0.643196157668955 0.246319276138129 no 839 0.260048413094245 1232 2919270
SGTC_350 k064-0020 19.8 µM 0.642936464417782 0.246412055321141 no 840 0.26013266367448 1291 2790705
SGTC_12 0849-0099 9.267 µM 0.642404300565254 0.246602237077995 no 841 0.260305354055331 1220 6071388
SGTC_1591 genipin 88.4 µM 0.642123170039751 0.246702737670456 no 842 0.260396606444708 1298 442424 A DNA cross-linking agent.
SGTC_3111 9122088 49.47 µM 0.640067980056723 0.247438107759143 no 843 0.261064202422427 1203 16876704
SGTC_63 0099-0242 26.702 µM 0.637587890538283 0.248327069062115 no 844 0.261870990222263 1271 3898502 YLR359W ADE13
SGTC_1214 0358-0031 63.7 µM 0.636795399489156 0.24861148744666 no 845 0.262129061564301 1404 4301366
SGTC_2075 5212009 200 µM 0.636375173967092 0.248762373230672 no 846 0.262265959078349 1250 780898
SGTC_3045 9092950 49.47 µM 0.635665526078334 0.249017289396987 no 847 0.262497225278159 1348 44120432
SGTC_3202 9113761 49.47 µM 0.634470751763952 0.249446784051703 no 848 0.262886824373226 1347 4798415
SGTC_797 k781-0471 270 µM 0.633029004607009 0.249965583623313 no 849 0.263357351174818 1301 23738129
SGTC_779 1360-0071 233 µM 0.632541405252639 0.250141171292572 no 850 0.263516580741507 1382 7566
SGTC_2960 9079389 5.97 µM 0.629878406213828 0.251101287606604 no 851 0.264387070976429 1301 16457355
SGTC_1373 2887-0003 58.5 µM 0.627865302329401 0.251828382869187 no 852 0.26504609137724 1293 776948
SGTC_442 cape 100 µM 0.626310008160914 0.252390886016649 no 853 0.265555811565435 1315 5281787
SGTC_1810 st050138 53 µM 0.624872228424187 0.252911476216959 no 854 0.266027460366896 1305 3444541
SGTC_2118 5526350 200 µM 0.624540316087526 0.253031735025831 no 855 0.266136401033239 1327 743594
SGTC_2404 5161160 200 µM 0.623522031855564 0.253400868438275 no 856 0.266470764408597 1278 2831543
SGTC_988 1497-1057 103 µM 0.623182480877319 0.253524020355514 no 857 0.266582306446195 1324 3533044
SGTC_2157 5649910 96.377 µM 0.620873688791073 0.254362230457365 no 858 0.267341367050541 1280 2858091
SGTC_1626 st003712 1.76 µM 0.618094795964937 0.25537303429985 no 859 0.26825642625601 1302 24207035
SGTC_3247 9135149 49.47 µM 0.617866460757052 0.255456182954608 no 860 0.268331684555985 1283 8934436 YOR116C RPO31
SGTC_1296 1068-0102 11.9 µM 0.617776479803126 0.255488953557452 no 861 0.268361344807212 1296 767053
SGTC_625 k213-0058 121 µM 0.617422628125866 0.255617845825899 no 862 0.268478000254324 1376 3655420
SGTC_2877 9040724 71.43 µM 0.616573606626649 0.255927244656515 no 863 0.268758003898711 1361 6463895
SGTC_3048 9093155 49.47 µM 0.6163616202302 0.256004526819495 no 864 0.268827938980683 1272 25236002
SGTC_2156 5649887 115 µM 0.615777853797514 0.256217408727069 no 865 0.26902057287298 1361 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_468 gf-109203x 121 µM 0.615412659348948 0.256350630977119 no 866 0.269141116610123 1255 2396 A protein kinase C inhibitor.
SGTC_2204 7233102 200 µM 0.615295079986516 0.256393531389669 no 867 0.269179933086466 1271 2172480
SGTC_2811 7967822 32.47 µM 0.61509288022145 0.256467315442813 no 868 0.26924669186444 1357 2232244
SGTC_2099 5377090 177.372 µM 0.614555937015637 0.256663303307217 no 869 0.269424010667473 1307 2243829
SGTC_521 r062-0005 13.8 µM 0.613984209690559 0.256872073303844 no 870 0.269612880822802 1276 2832033
SGTC_285 1486-1325 46 µM 0.613832816946664 0.256927370155523 no 871 0.269662904530548 1344 22310230
SGTC_2514 salinomycin 42.74 µM 0.61355208909839 0.257029923599321 no 872 0.269755675887614 1368 23682228 A polyether potassium ionophore.
SGTC_1488 4013-0813 75.9 µM 0.613018063200666 0.257225068794822 no 873 0.269932198062012 1292 2910057
SGTC_2455 5377712 9.75 µM 0.612766170994846 0.257317142655966 no 874 0.27001548105253 1267 2243908
SGTC_1186 1319-0216 26 µM 0.610159985208066 0.258270783143748 no 875 0.270877916919269 1381 4565136
SGTC_1606 st000094 49.2 µM 0.610117181382933 0.258286460948395 no 876 0.270892092975949 1359 1242210
SGTC_1938 st074717 56.4 µM 0.606039017768698 0.259782433447344 no 877 0.27224442203517 1255 17250979
SGTC_1853 st056710 91.2 µM 0.605028693371143 0.260153735550936 no 878 0.2725799658551 1481 269167
SGTC_2220 6782180 200 µM 0.604599182634506 0.260311666923396 no 879 0.272722674949196 1282 833803
SGTC_1224 0823-0416 294 µM 0.603999960338969 0.260532083844304 no 880 0.272921834270026 1396 3598164
SGTC_2788 5282734 71.43 µM 0.60366558459644 0.260655121813977 no 881 0.273032999737977 1429 743706
SGTC_2851 9015922 71.43 µM 0.603218585583043 0.260819647703132 no 882 0.273181642621451 1375 2996893
SGTC_1651 st011928 86.1 µM 0.602875210814534 0.260946069129823 no 883 0.273295854025573 1340 720198
SGTC_1640 st009078 66.4 µM 0.602854875395642 0.26095355707665 no 884 0.273302618621131 1369 690618
SGTC_876 0720-0963 56.8 µM 0.601874283448561 0.26131476360106 no 885 0.273628911805234 1436 765861
SGTC_1743 st037606 46.3785 µM 0.60172445878053 0.261369974965005 no 886 0.273678783118615 1369 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_813 k007-0158 173 µM 0.599382020071831 0.262233957274899 no 887 0.274459082035303 1369 6523916
SGTC_3024 9090631 49.47 µM 0.599241617314076 0.262285789699445 no 888 0.274505886999589 1296 25236383
SGTC_3016 9080866 49.47 µM 0.59908906997768 0.26234211148042 no 889 0.274556744970425 1329 17066299
SGTC_2063 5246145 200 µM 0.598145935686743 0.262690462197472 no 890 0.274871281011115 1388 711240
SGTC_1898 st060199 18.6 µM 0.597085760928297 0.263082324642095 no 891 0.275225062028083 1335 688866
SGTC_743 1275-0778 158 µM 0.596947577288308 0.263133422159627 no 892 0.275271190507765 1365 2849257 YMR203W TOM40
SGTC_2200 6600604 21.907 µM 0.596515773232116 0.263293127246797 no 893 0.275415359912137 1302 2904777
SGTC_3014 9081533 49.47 µM 0.595563409726592 0.263645538991159 no 894 0.275733463360937 1377 21367265
SGTC_2996 9066192 71.4286 µM 0.594539746222801 0.264024602676261 no 895 0.276075583305401 1310 6472854
SGTC_2283 7944793 200 µM 0.594305582489093 0.264111352770792 no 896 0.276153872758925 1296 2970533
SGTC_159 3970-0959 50 µM 0.593714607218342 0.264330354556431 no 897 0.276351505731065 1408 6615653
SGTC_2122 5258151 111.688 µM 0.593029886717803 0.264584211722787 no 898 0.276580575555893 1327 2173356
SGTC_2748 diazoxide 86.69 µM 0.592763990246671 0.264682825112672 no 899 0.276669554975427 1347 3019 A potassium channel activatior.
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.592732877607927 0.264694365121223 no 900 0.27667996740497 1385 551469
SGTC_155 k072-0202 43.6 µM 0.590641996693924 0.265470481036194 no 901 0.277380159754878 1302 5857737
SGTC_2723 salbutamol 83.58 µM 0.590370391124313 0.265571383212524 no 902 0.277471178327862 1358 9884233 β2-adrenoceptor agonist
SGTC_1132 3456-3614 2.5 µM 0.590171028154233 0.26564545945266 no 903 0.277537996751397 1484 3125502
SGTC_2977 9011197 71.43 µM 0.58975920088467 0.265798513094854 no 904 0.277676049528777 1412 2704722
SGTC_523 1934-0222 13.7 µM 0.589575876220159 0.265866659206971 no 905 0.277737514427956 1348 1361595
SGTC_327 1273-0057 3.96 µM 0.589489801841986 0.265898658142567 no 906 0.277766375646279 1304 3108138
SGTC_820 1582-0060 59.9 µM 0.588829310939614 0.266144266588054 no 907 0.277987890647657 1337 3848840
SGTC_27 0485-0001 32.618 µM 0.588715188465416 0.266186715513096 no 908 0.278026173699675 1311 2054479
SGTC_1851 st056236 18.9 µM 0.584445484183722 0.267777331198582 no 909 0.279460316462726 1395 5393171
SGTC_1142 3253-1408 9.78 µM 0.584356680559523 0.267810464451902 no 910 0.279490182639133 1358 256655
SGTC_153 4077-0274 519.67 µM 0.584010694305362 0.26793957403932 no 911 0.279606558510086 1461 3121976
SGTC_1024 4507-0395 26 µM 0.582982602433111 0.268323405694672 no 912 0.279952506027693 1392 4201836
SGTC_681 1642-0006 26.6 µM 0.582494646651653 0.268505677662907 no 913 0.280116773182956 1359 4446530
SGTC_1034 k072-0165 12.7 µM 0.582470281201575 0.268514780812745 no 914 0.280124976878303 1393 5835461
SGTC_1955 wogonin 32.4 µM 0.581382951336066 0.268921174844975 no 915 0.280491192557063 1440 5281703 A flavanone.
SGTC_2374 9071832 200 µM 0.579918386531004 0.269469049665306 no 916 0.280984827974739 1332 17381698
SGTC_513 4245-1575 41.7 µM 0.579543693068372 0.269609307484439 no 917 0.281111186800409 1355 719745
SGTC_1954 st077032 68.9 µM 0.578778293123335 0.26989593084871 no 918 0.281369389833084 1294 698907
SGTC_807 1315-0151 48 µM 0.57857292178456 0.269972863285745 no 919 0.281438690081128 1395 4011080
SGTC_2567 aureobasidin a 60 nM 0.578088975855757 0.270154193606257 no 920 0.281602024753443 1443 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1061 3448-9325 110 µM 0.577902257809391 0.270224171512697 no 921 0.281665055440558 1341 723482
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.577465262374557 0.270387983423679 no 922 0.281812599220749 1387 5379071
SGTC_2394 5221648 200 µM 0.576776433717754 0.270646298161739 no 923 0.282045245636779 1497 788586
SGTC_2852 9023854 51.95 µM 0.576433470142542 0.270774957432047 no 924 0.282161113342811 1446 19798528
SGTC_3040 9091894 49.47 µM 0.576341043836133 0.270809635435872 no 925 0.282192342805653 1320 25236966
SGTC_1322 1348-1070 12 µM 0.576143952356697 0.27088359082359 no 926 0.282258942616738 1355 6758089
SGTC_59 0330-0160 1.33 µM 0.575747377415654 0.271032429688666 no 927 0.282392973438626 1368 4293482
SGTC_1563 conessine 56.1 µM 0.574404724814783 0.271536644390926 no 928 0.282846978194437 1434 441082 An anti-amoebic, histamine inhibitor.
SGTC_1045 1348-1485 165 µM 0.574194263029172 0.271615722750359 no 929 0.282918175545019 1373 6810614
SGTC_3300 9124615 50.48 µM 0.573933378549722 0.271713762714638 no 930 0.283006442387884 1453 24824903
SGTC_2756 carbadox 75.1 µM 0.571026747248226 0.272807259985795 no 931 0.283990756022053 1373 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2324 6149169 200 µM 0.57005041700675 0.273175052183421 no 932 0.284321751659214 1329 2888231
SGTC_1621 st003705 32.4 µM 0.569608622197798 0.273341560881911 no 933 0.284471589576994 1426 24207032
SGTC_3071 9117417 49.47 µM 0.569254191708583 0.273475179039212 no 934 0.284591824514966 1352 45595590 YGL055W OLE1
SGTC_1250 0485-0349 40.2 µM 0.568774638692988 0.27365601908956 no 935 0.284754543909356 1386 6842794 YDL195W SEC31
SGTC_2120 5538279 151.968 µM 0.568661538183552 0.273698678055652 no 936 0.284792927046328 1424 2058197
SGTC_906 1165-0455 526 µM 0.566486252527526 0.274519786325088 no 937 0.285531637872995 1346 3252859
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.564808417968787 0.275153950191073 no 938 0.286102040355292 1346 1241132 A phosphatase inhibitor.
SGTC_1525 8-methoxypsoralen 92.5 µM 0.564333135360248 0.275333721725903 no 939 0.286263717428718 1487 4114 Related to psoralen; DNA damaging agent.
SGTC_85 0868-0259 160.055 µM 0.563687371241609 0.275578069001031 no 940 0.286483456755971 1412 83173
SGTC_1776 st049249 45.9 µM 0.56231580807849 0.276097401043486 no 941 0.286950434865378 1356 1822314
SGTC_2038 4100038 30.985 µM 0.562155453786099 0.27615814934264 no 942 0.287005054460773 1412 3596803
SGTC_1490 4089-0339 670 nM 0.56061608559124 0.276741654073902 no 943 0.287529641707213 1380 742542
SGTC_2490 carminic acid 95.39 µM 0.557755560436831 0.277827551056203 no 944 0.288505656114153 1369 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_33 0986-0033 35.816 µM 0.556699992461037 0.27822878482609 no 945 0.28886621103956 1393 2848082
SGTC_990 3985-0011 41.3 µM 0.5566145371722 0.278261279742249 no 946 0.28889540964978 1404 5399565 YGL099W LSG1
SGTC_1379 2144-0755 36.5 µM 0.556361802084055 0.278357394691071 no 947 0.288981773033049 1433 5392327
SGTC_1169 aniline yellow 25.8 µM 0.555438982050923 0.278708479743175 no 948 0.289297217627432 1413 6051 A DNA damaging agent.
SGTC_1346 1488-2224 62.4 µM 0.554557324845949 0.27904410572164 no 949 0.289598742736499 1426 3722427
SGTC_835 0312-0010 67.2 µM 0.553998351668321 0.279256995307712 no 950 0.289789986906007 1374 1626196
SGTC_29 0299-0004 12.984 µM 0.553901832187748 0.279293763544836 no 951 0.289823015576053 1314 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2447 5741742 33.78 µM 0.5511671869564 0.280336478627084 no 952 0.290759535737652 1492 1776504
SGTC_1101 ebselen 5.29 µM 0.549299241361454 0.281049804748628 no 953 0.291400053955468 1471 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_3249 9135183 49.47 µM 0.548495329431741 0.281357070199007 no 954 0.291675917697643 1439 4902779
SGTC_1731 st035964 63 µM 0.548468461040217 0.281367342442247 no 955 0.291685139733588 1440 6739575
SGTC_362 0310-0100 9.03 µM 0.548311680178759 0.281427286042554 no 956 0.291738954326535 1422 790235
SGTC_1185 1319-0113 81.3 µM 0.548292283608632 0.281434702556224 no 957 0.291745612466679 1448 4672763
SGTC_714 4296-0578 26.1 µM 0.547875875786885 0.28159394387466 no 958 0.29188856726767 1417 1589775
SGTC_73 0327-0325 16.231 µM 0.546594982686527 0.282084051065164 no 959 0.292328508414017 1425 53298
SGTC_2255 7941087 197.44 µM 0.546047250632234 0.282293754678248 no 960 0.292516728941165 1503 935561
SGTC_514 4466-0038 2.65 nM 0.545620848962547 0.282457057890756 no 961 0.292663294942071 1423 5722064
SGTC_3136 9095672 49.47 µM 0.545184589201139 0.282624183557357 no 962 0.292813284735387 1322 17217380
SGTC_2223 6903751 107.57 µM 0.542284989529807 0.283736190071323 no 963 0.293811097273934 1419 5598863
SGTC_2225 6654152 15.4 µM 0.541736259895097 0.283946865321082 no 964 0.294000103423297 1427 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_3144 9087057 49.47 µM 0.541388436492463 0.284080444850574 no 965 0.294119937903863 1408 17249618
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.540848752984983 0.284287766605912 no 966 0.294305918000731 1471 5024745
SGTC_933 2914-0560 114 µM 0.539812457341284 0.284686066709115 no 967 0.294663187574759 1540 463887
SGTC_1790 st045711 43.5 µM 0.539731026062122 0.284717376096439 no 968 0.29469127000617 1548 585119
SGTC_2997 9067075 71.4286 µM 0.539498996451506 0.284806597817188 no 969 0.294771294621623 1466 27209819
SGTC_2475 5812728 15.03 µM 0.538194910118955 0.285308302666245 no 970 0.295221246816366 1397 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2145 5634607 200 µM 0.537470483023096 0.285587184230613 no 971 0.295471334246277 1404 308662
SGTC_1559 coumarin 343 70.1 µM 0.536341870246645 0.286021922850487 no 972 0.295861149077195 1491 108770 A hepatotoxic, DNA x-linker.
SGTC_381 3461-2219 42.7 µM 0.535853515441212 0.286210133249198 no 973 0.296029896539857 1491 2883159
SGTC_2117 5521686 200 µM 0.534722622684479 0.286646201411745 no 974 0.296420837839656 1387 803312
SGTC_502 l-744,832 89.3 µM 0.534609664550587 0.286689774961452 no 975 0.296459899630673 1464 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_703 3875-0075 71.8 µM 0.534356946477128 0.286787272217183 no 976 0.296547300025158 1494 2850814
SGTC_453 enantio-paf c16 10 µM 0.530841169471447 0.288145267282868 no 977 0.297764424117606 1422 13871343 A lipid and platelet activating factor
SGTC_133 0724-0033 378.92 µM 0.528806839528057 0.288932425556072 no 978 0.298469726330972 1336 280309
SGTC_2625 euphol 100 µM 0.528127485245522 0.28919551830445 no 979 0.298705427659064 1543 6708538 A triterpene alcohol.
SGTC_1220 1838-0075 193 µM 0.527581089565129 0.289407202013183 no 980 0.298895060499924 1431 5529645
SGTC_3238 9133470 49.47 µM 0.527266275542155 0.289529199783115 no 981 0.299004345118057 1517 3534688
SGTC_3319 9138450 16.7555 µM 0.527145395408065 0.28957605006774 no 982 0.299046312298597 1430 2029690
SGTC_758 0868-0029 16 µM 0.52608013529201 0.289989073541402 no 983 0.299416265020584 1487 762687
SGTC_2557 derrustone 83.84 µM 0.525851169220745 0.29007788449263 no 984 0.29949580942117 1408 629853 An antioxidant.
SGTC_315 k915-0449 187 µM 0.525468455354885 0.290226359319987 no 985 0.299628788254372 1501 20970215 YNL149C PGA2
SGTC_503 tyrphostin 8 294 µM 0.523381850868553 0.291036488399976 no 986 0.300354275752985 1479 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1339 1486-1321 22.7 µM 0.52186486832844 0.291626122804036 no 987 0.300882210282506 1448 3469382
SGTC_812 4251-0442 148 µM 0.521424231853678 0.291797497665971 no 988 0.301035637324537 1448 5723007
SGTC_1012 4112-3522 18 µM 0.519393372245962 0.292587957053834 no 989 0.30174322611133 1495 3112398
SGTC_2098 5376439 882.5 nM 0.519257742409588 0.292640782869617 no 990 0.301790508662602 1553 2844116
SGTC_3175 9106517 49.47 µM 0.518430133796806 0.292963220147896 no 991 0.302079097302462 1414 41468073
SGTC_2948 9070189 9.45 µM 0.517696957386045 0.293249004165349 no 992 0.302334860721862 1497 6473636 YDL196W YDL196W
SGTC_1641 st009299 47.1 µM 0.517232087540843 0.293430272184611 no 993 0.302497077594156 1423 4046054
SGTC_970 1315-0089 19.5 µM 0.516974309350995 0.293530810733618 no 994 0.302587046407486 1390 6811083 YLR033W RSC58
SGTC_1795 st049545 62.3 µM 0.51654157377934 0.293699621950513 no 995 0.302738105171751 1469 5291882
SGTC_2704 st078022 71.1 µM 0.516308233261791 0.293790667306321 no 996 0.302819573388043 1561 54697681
SGTC_688 0527-0193 473 µM 0.515925715346579 0.293939947295069 no 997 0.302953146446975 1489 4007154
SGTC_227 fluconazole 33.516 µM 0.513976070122361 0.294701352859587 no 998 0.303634360676961 1416 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1975 st070967 30.8 µM 0.513449381326575 0.294907199448076 no 999 0.303818505205375 1525 261391
SGTC_2746 daunorubicin 9.88 µM 0.512363420687266 0.295331836131367 no 1000 0.304198343339291 1446 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2965 9082772 38.63 µM 0.510052358280802 0.296236452214522 no 1001 0.305007390461857 1540 16459634
SGTC_236 1509-0011 5.31 µM 0.509522834470852 0.296443901841136 no 1002 0.305192898440435 1490 3107280
SGTC_1166 k206-0078 225 µM 0.508483554053811 0.296851250428652 no 1003 0.305557134857244 1435 5404595
SGTC_719 2810-4230 27.3 µM 0.508429050032757 0.296872620485478 no 1004 0.305576242187432 1479 721079
SGTC_1547 harmine 94.2 µM 0.507841686458059 0.29710295995143 no 1005 0.305782186269501 1473 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1044 1222-0021 1.78 µM 0.506477735826987 0.297638159384811 no 1006 0.306260657730479 1490 4306703
SGTC_538 2922-0838 53.3 µM 0.506232858566286 0.297734293134477 no 1007 0.306346595268451 1598 777039
SGTC_2348 9022543 33.42 µM 0.505441978664124 0.298044872942665 no 1008 0.306624220419479 1501 3162678 YDL140C RPO21
SGTC_705 1124-0212 310 µM 0.50533760233004 0.298085872722288 no 1009 0.306660868278548 1551 9554485
SGTC_610 4215-0184 155 µM 0.504971897642764 0.298229544441744 no 1010 0.306789287097334 1505 5605015
SGTC_4 0960-0234 25.671 µM 0.50417284891512 0.298543570529053 no 1011 0.307069959099846 1469 6821112
SGTC_1908 st060353 56.5 µM 0.502035514523175 0.299384281079217 no 1012 0.307821269690833 1638 4227716
SGTC_2520 obtusaquinone 4.71 µM 0.501818452466473 0.299469721451641 no 1013 0.307897615978292 1565 5967872
SGTC_1498 4478-3555 97.6 µM 0.501546598492645 0.29957674470993 no 1014 0.307993245717141 1506 3437919
SGTC_1712 st032288 53.4 µM 0.501435844089038 0.299620351384857 no 1015 0.308032209396501 1441 2883011
SGTC_171 k064-0041 9.68 µM 0.500163730300103 0.300121419292825 no 1016 0.308479897324081 1414 53325
SGTC_3183 9108214 49.47 µM 0.499996067146497 0.300187487731135 no 1017 0.308538923348702 1434 4974831
SGTC_2778 tioconazole 65.09 nM 0.498838737986571 0.300643717874093 no 1018 0.308946497439867 1435 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1763 st044482 94.5 µM 0.497872568351363 0.301024830659961 no 1019 0.309286931579253 1532 88505
SGTC_246 cycloheximide 667 µM 0.497624525702913 0.30112270804437 no 1020 0.309374356935495 1426 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1526 st051518 75 µM 0.497506049768593 0.301169463591257 no 1021 0.309416118888616 1484 673993
SGTC_2859 9028643 45.46 µM 0.496351300362408 0.301625347075213 no 1022 0.309823288977104 1476 17151580
SGTC_433 pimozide 108 µM 0.496337461184402 0.301630812525619 no 1023 0.309828170152987 1418 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_3264 9137442 49.47 µM 0.495505554317817 0.301959435906839 no 1024 0.31012165114367 1565 17015726
SGTC_1929 genistein trimethyl ether 50.5 µM 0.495405431668916 0.301998997621526 no 1025 0.310156980679289 1635 136420
SGTC_1924 st058459 75.1 µM 0.494964344032899 0.302173313403979 no 1026 0.310312644860279 1476 688683
SGTC_1782 st039423 80.636 µM 0.494591330061175 0.302320762026451 no 1027 0.310444311699274 1442 2068169
SGTC_1297 1068-0111 14.1 µM 0.493961494935403 0.302569802667181 no 1028 0.310666686655322 1425 767057
SGTC_82 0054-0107 293.755 µM 0.493807887111637 0.302630554079518 no 1029 0.310720931240629 1577 3104697
SGTC_1487 3970-0795 2.82 µM 0.493779892106988 0.302641626604848 no 1030 0.310730817752124 1527 3765103
SGTC_1349 flufenamic acid 69 µM 0.492708446880638 0.303065538710096 no 1031 0.311109304182118 1455 3371 A non-steroidal anti-inflammatory.
SGTC_2004 4023728 41.89 µM 0.492305025744239 0.303225219135911 no 1032 0.3112518639077 1532 360084 YDR527W RBA50
SGTC_2659 sanguinarine 24.21 µM 0.491687555550204 0.303469696362619 no 1033 0.311470118465592 1474 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_367 0335-0881 7.1 µM 0.489428460932132 0.304364897303244 no 1034 0.312269195317394 1558 23828853
SGTC_890 0929-0006 47.2 µM 0.48934935460642 0.304396265695092 no 1035 0.312297192490868 1448 1378169
SGTC_2434 5670830 169.91 µM 0.488464114557362 0.304747392078163 no 1036 0.312610569006984 1499 1549830
SGTC_1255 0566-0045 221 µM 0.486671045068607 0.305459155924018 no 1037 0.313245733824699 1569 2788469
SGTC_353 1988-1175 58.3 µM 0.486477209088721 0.305536143774039 no 1038 0.31331443021205 1422 2788357
SGTC_2989 9073649 71.4286 µM 0.485497090989559 0.305925559079363 no 1039 0.313661887850896 1521 21367202
SGTC_593 1203-0218 61.7 µM 0.481322972136392 0.307586451483631 no 1040 0.315143486338407 1590 3666956
SGTC_1516 st013856 110 µM 0.480042916223228 0.308096582364816 no 1041 0.315598438560025 1493 5281404 A mutagen and neurotoxin.
SGTC_2041 5107442 45.335 µM 0.47969098245949 0.308236900891116 no 1042 0.315723570450516 1584 793005
SGTC_394 menadione 8.33 µM 0.479034338482085 0.308498784495105 no 1043 0.315957100124651 1515 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2121 5257820 149.641 µM 0.477222675139439 0.309221819487116 no 1044 0.316601783047144 1576 791256
SGTC_2523 spermine 47.74 µM 0.476345717110247 0.309572079308813 no 1045 0.316914050172081 1606 1103 A DNA binding polyamine.
SGTC_1351 1496-0003 46.5 µM 0.475804876823312 0.309788178920359 no 1046 0.317106697582715 1561 3891978
SGTC_2019 4016004 108 µM 0.475120311399793 0.31006180001645 no 1047 0.31735061100392 1462 45595336
SGTC_157 1348-1695 65.819 µM 0.474377571079499 0.310358792654273 no 1048 0.317615342119423 1484 5380510
SGTC_2886 9058944 51.95 µM 0.473339188263089 0.310774208428564 no 1049 0.317985603928545 1463 4949929
SGTC_3322 9139058 2.11 µM 0.472924136221785 0.310940321826081 no 1050 0.318133652231142 1574 4908926 YPR165W RHO1
SGTC_3230 9131665 49.47 µM 0.471842970207166 0.311373210243268 no 1051 0.318519438573563 1517 15943720
SGTC_2477 5967686 25.23 µM 0.471236536576359 0.311616134678934 no 1052 0.318735915047892 1462 776118
SGTC_586 0957-0265 8.15 µM 0.469305265764574 0.312390306847179 no 1053 0.319425725948147 1475 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1933 st074711 15.9 µM 0.468070138292842 0.312885856739989 no 1054 0.319867216577782 1485 17250958
SGTC_1043 0916-0009 19.3 µM 0.46803670102708 0.312899276931517 no 1055 0.319879172126331 1716 3101130
SGTC_2010 4012422 159 µM 0.467995442896452 0.312915836402774 no 1056 0.31989392429565 1577 952393
SGTC_1624 st003710 6.25 µM 0.467714676304264 0.31302853564011 no 1057 0.319994322164176 1618 24207033
SGTC_2316 5844804 197.44 µM 0.467361776982154 0.313170213614494 no 1058 0.320120532301688 1612 776813
SGTC_3257 9139206 32.98 µM 0.467059928826573 0.313291418040704 no 1059 0.320228501131016 1567 4910041
SGTC_111 0083-0039 52.457 µM 0.466007148623314 0.31371431030251 no 1060 0.320605191827052 1492 759313
SGTC_1124 fisetin 1.16336 µM 0.465396934257325 0.31395954002783 no 1061 0.320823614613948 1518 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_3142 9086498 49.47 µM 0.46500420379208 0.314117411948891 no 1062 0.320964223083269 1510 25236367
SGTC_1819 st053448 58.6 µM 0.463678464122176 0.314650591087038 no 1063 0.321439064456059 1569 2857616
SGTC_2180 6301957 200 µM 0.462291214278641 0.315208922141272 no 1064 0.321936249589959 1547 845462
SGTC_3150 9097574 49.47 µM 0.46016332753866 0.316066160324769 no 1065 0.322699495784624 1663 17217476
SGTC_1687 st020778 55.3625 µM 0.458191201739415 0.316861532884034 no 1066 0.323407540171162 1558 4259299
SGTC_1779 st039427 55 µM 0.457277579521882 0.317230290696575 no 1067 0.323735771362059 1704 1124498
SGTC_3054 9094397 49.47 µM 0.455775111667827 0.317837114049366 no 1068 0.324275851488818 1474 2598354
SGTC_1218 1348-1416 30.7 µM 0.455280171007843 0.318037120146163 no 1069 0.324453844915215 1543 6787668
SGTC_2196 6573537 42.6665 µM 0.453699015072923 0.31867642252425 no 1070 0.325022737963417 1638 2903087
SGTC_1907 st060210 83.7 µM 0.452549565944968 0.319141513795337 no 1071 0.325436561109484 1626 688793
SGTC_2675 theaflavin digallate 100 µM 0.452483746504052 0.319168154352482 no 1072 0.32546026385898 1566 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1771 st048882 4.1505 µM 0.451994790704879 0.319366089470017 no 1073 0.325636367620601 1488 4580403
SGTC_3086 9117350 49.47 µM 0.448826770325264 0.320649787218801 no 1074 0.3267783127985 1489 2679265
SGTC_3329 9141233 27.5565 µM 0.4484981643489 0.32078306322006 no 1075 0.326896855334671 1635 4909101 YNL103W MET4
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.447981243609834 0.320992762665697 no 1076 0.327083366591425 1581 66535 A nucleotide analog.
SGTC_3180 9109287 49.47 µM 0.447095995263485 0.321352014340784 no 1077 0.327402875212261 1553 18891271
SGTC_656 4090-1979 187 µM 0.446272092386468 0.3216865210232 no 1078 0.327700356338546 1666 22330961
SGTC_3105 9121040 49.47 µM 0.446122092267628 0.321747437023818 no 1079 0.327754527659234 1497 41448907
SGTC_3162 9099653 49.47 µM 0.444750808847742 0.322304545896721 no 1080 0.328249923425725 1572 25237511
SGTC_3338 9144300 39.5675 µM 0.443375702569033 0.32286360896888 no 1081 0.328747003742758 1609 4901274
SGTC_210 3551-0445 56.827 µM 0.443359540522682 0.322870182192693 no 1082 0.328752847884329 1592 2865180 YOR207C RET1
SGTC_1303 1160-0052 261 µM 0.443202275346614 0.322934145991802 no 1083 0.328809716628828 1564 3562476
SGTC_1275 0867-0008 21.1 µM 0.442842441882248 0.323080519232813 no 1084 0.32893985110954 1581 3422836
SGTC_2240 6690706 185.951 µM 0.442610844131681 0.323174743179331 no 1085 0.329023619862189 1485 805876
SGTC_1423 4048-0112 5.59 µM 0.441160513431088 0.323765058010495 no 1086 0.329548398640159 1643 X1423
SGTC_601 0986-0029 62.9 µM 0.439895766329566 0.324280198649741 no 1087 0.330006301174108 1559 24747981
SGTC_102 gallobenzophenone 83.616 µM 0.438907888845804 0.324682802446893 no 1088 0.330364140164137 1657 70837
SGTC_877 0771-0151 33.1 µM 0.438698216290146 0.324768279671373 no 1089 0.330440109855347 1602 6166523
SGTC_3318 9139014 38.6185 µM 0.437913288498673 0.325088353142219 no 1090 0.330724571152997 1571 16643984
SGTC_3244 9134489 49.47 µM 0.437598548562548 0.32521673231648 no 1091 0.33083866177239 1512 16584271
SGTC_1456 k015-0012 13 µM 0.436521126578319 0.325656358638852 no 1092 0.331229337233186 1748 2989616
SGTC_828 2074-0507 139 µM 0.436305096751465 0.325744535675396 no 1093 0.331307692230496 1658 X828
SGTC_1976 st070609 63.5 µM 0.435751871435243 0.325970390460893 no 1094 0.331508383227933 1533 682556
SGTC_525 k781-2675 26.7 µM 0.435163330157751 0.326210733136609 no 1095 0.33172193875066 1593 3651118 YDL195W SEC31
SGTC_924 2046-0044 21.3 µM 0.43500439865688 0.326275648398158 no 1096 0.331779617325156 1521 3623589
SGTC_1053 3366-3204 134 µM 0.434642866594398 0.326423335065383 no 1097 0.331910837468616 1540 3632071 YPR165W RHO1
SGTC_2427 5545055 42.75 µM 0.434421683986172 0.326513702082012 no 1098 0.331991127137639 1618 5372858
SGTC_1000 4048-0884 8.67 µM 0.434339857488773 0.326547135936763 no 1099 0.332020832252835 1607 13040088
SGTC_1785 bathophenanthroline 24 µM 0.433253326544924 0.326991218471615 no 1100 0.332415370846507 1520 72812 An iron chelator.
SGTC_522 1273-0010 11.6 µM 0.43270958193539 0.327213547634952 no 1101 0.332612883896047 1625 5705015
SGTC_1906 st060206 94.7 µM 0.432022782774587 0.327494457334305 no 1102 0.332862427358972 1674 5133468
SGTC_1341 1486-1360 280 µM 0.431929955682533 0.327532432307883 no 1103 0.332896161088471 1553 3976547
SGTC_2935 9038016 29.96 µM 0.431648134416146 0.32764773452832 no 1104 0.332998584328191 1599 6463195
SGTC_2419 paclitaxel 166.5 µM 0.431433696172762 0.327735479181386 no 1105 0.333076526679818 1610 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2457 5731572 11.68 µM 0.431024872414886 0.327902789588694 no 1106 0.333225142749453 1709 2865357
SGTC_891 0929-0073 133 µM 0.429649555775788 0.328465888948143 no 1107 0.333725291527488 1640 5603632
SGTC_2292 7671323 168.05 µM 0.425085627359279 0.330337297182151 no 1108 0.335387127461822 1562 937504
SGTC_946 3434-1334 87.4 µM 0.424570354578903 0.330548849277642 no 1109 0.335574953926785 1668 4047976
SGTC_580 1123-0028 41 µM 0.423477980552418 0.330997516996136 no 1110 0.335973280335446 1620 1677248 YPR107C YTH1
SGTC_374 0880-0231 82.3 µM 0.42242067279884 0.331432013317281 no 1111 0.33635899560868 1616 6833587
SGTC_1501 4491-0275 38.4 µM 0.420704047700939 0.332137936642104 no 1112 0.336985602542301 1677 5104718
SGTC_620 0109-0052 432 µM 0.420349106027944 0.332283972845454 no 1113 0.33711522079803 1681 493037
SGTC_1736 st036774 51 µM 0.420112388527117 0.332381381386409 no 1114 0.337201676483411 1783 1272247
SGTC_188 3229-0966 278.469 µM 0.419591356984396 0.332595824182475 no 1115 0.337392001693782 1731 5722370
SGTC_2858 9025781 8.96 µM 0.418617143425927 0.332996931666053 no 1116 0.337747979286385 1630 4894980 YPL153C RAD53
SGTC_2860 9025725 38.96 µM 0.418360593037434 0.333102591534244 no 1117 0.337841746952888 1543 40546248
SGTC_2027 5150920 200 µM 0.417766297374829 0.333347402139202 no 1118 0.338058997194561 1652 786715
SGTC_245 methotrexate 289.6 µM 0.416553990252773 0.333847012766078 no 1119 0.338502334396632 1639 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1886 st057356 49.9 µM 0.416532350442017 0.333855933548401 no 1120 0.338510250048665 1534 24207747
SGTC_2829 7992743 58.44 µM 0.416524118207802 0.333859327224243 no 1121 0.338513261346112 1779 16462845
SGTC_189 3970-0742 2.116 µM 0.415742204712749 0.334181727014465 no 1122 0.338799327232419 1674 2891807
SGTC_563 tetrahydrosecaminediol 614 µM 0.415467201811208 0.33429514574161 no 1123 0.338899960156188 1700 334274 A psychoactive constituent of the cannabis plant.
SGTC_1062 mesoridazine 14.2 µM 0.414744463962793 0.33459329473102 no 1124 0.339164489342465 1610 4078 A neuroleptic.
SGTC_612 0302-0167 22.4 µM 0.414345571944175 0.334757893216458 no 1125 0.339310521729422 1692 235821
SGTC_888 0916-0002 6.97 µM 0.414022239088435 0.334891336332731 no 1126 0.339428909995696 1685 2802138 YIL048W NEO1
SGTC_1277 0873-0036 22 µM 0.413476096575596 0.335116782851733 no 1127 0.339628915967229 1700 5965735
SGTC_2468 5987765 72.9 µM 0.413235682058239 0.335216044314207 no 1128 0.339716973863328 1642 26772094
SGTC_2049 5262831 67.185 µM 0.413093356407948 0.335274812628812 no 1129 0.339769108354584 1615 763417
SGTC_2884 9058502 51.95 µM 0.409069667400357 0.336937915334288 no 1130 0.34124426774744 1572 6471554
SGTC_435 c-PAF 6.7 µM 0.408668023084857 0.337104101905905 no 1131 0.341391651759061 1620 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_3157 9099274 49.47 µM 0.407192647238032 0.337714834275074 no 1132 0.34193325075068 1707 17217662
SGTC_274 sirtinol 40.1 µM 0.406970558294489 0.33780680513996 no 1133 0.342014806081662 1561 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1145 3546-0597 10.2 µM 0.405757925805593 0.338309147871958 no 1134 0.342460237972662 1609 875334
SGTC_2130 NSC 7 2.4545 µM 0.405201770119888 0.338539636192153 no 1135 0.342664601982925 1735 21448
SGTC_2160 5660466 132.927 µM 0.404854070835919 0.338683764394084 no 1136 0.342792390365428 1705 2859134
SGTC_3251 9135047 49.47 µM 0.404262245324538 0.338929142049283 no 1137 0.343009942745642 1721 17682963
SGTC_1884 5633444 25 µM 0.403574010877296 0.339214577921436 no 1138 0.343263000077047 1647 5724239
SGTC_661 1304-0007 33.6 µM 0.402488972556411 0.339664770213982 no 1139 0.343662101196977 1595 3117130
SGTC_1217 1183-1422 255 µM 0.400828345037876 0.340354222679461 no 1140 0.34427325421377 1699 2849664
SGTC_2670 beta-carotene 100 µM 0.400442060638249 0.340514675273487 no 1141 0.344415475054153 1644 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_1259 0671-0132 43 µM 0.399325221451325 0.34097874383051 no 1142 0.344826792701226 1613 X1259
SGTC_2601 securinine 100 µM 0.398512199798859 0.341316721686949 no 1143 0.345126333645444 1592 442872 A GABA receptor antagonist.
SGTC_3199 9111318 49.47 µM 0.398088220662319 0.341493022821666 no 1144 0.345282578472231 1698 8548020
SGTC_1278 0874-0585 172 µM 0.398067767646882 0.341501528572205 no 1145 0.345290116486199 1665 766306
SGTC_1479 0549-0158 134 µM 0.39778401672089 0.341619539748971 no 1146 0.34539469998546 1633 5440202
SGTC_1548 st061468 90.8 µM 0.397331922216433 0.341807596508219 no 1147 0.345561355105687 1700 390799
SGTC_3287 9117173 37.0625 µM 0.396544494508498 0.342135234808754 no 1148 0.345851695219328 1631 2789709
SGTC_365 0121-0052 13.6 µM 0.395933614400618 0.342389495885168 no 1149 0.346077001218977 1669 3101739
SGTC_2669 eugenol 100 µM 0.39548307877222 0.342577064024406 no 1150 0.346243203577326 1725 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1287 0971-0001 34.6 µM 0.395476799920587 0.342579678326306 no 1151 0.346245520051735 1663 4665869
SGTC_2894 9048625 32.47 µM 0.395338492111727 0.342637266942128 no 1152 0.346296547799732 1753 4092861
SGTC_2298 7976326 193.81 µM 0.39469919922634 0.342903503270204 no 1153 0.346532446908208 1630 2235818
SGTC_741 4582-0002 126 µM 0.393781799748551 0.34328569461125 no 1154 0.346871071354214 1596 2912688
SGTC_566 0958-0068 16.5 µM 0.392672430225914 0.343748075390406 no 1155 0.347280717929631 1676 6815365
SGTC_902 1120-0002 2.07 µM 0.392281584850415 0.34391103391964 no 1156 0.347425084311004 1580 3280475
SGTC_585 0kpi-0023 191 µM 0.389967800907473 0.344876332900317 no 1157 0.348280178434675 1734 64601
SGTC_2222 6885208 172.143 µM 0.388159567584016 0.345631422621759 no 1158 0.348948976159034 1664 609514
SGTC_3015 9080845 49.47 µM 0.387445058083954 0.345929960095062 no 1159 0.349213375978503 1755 5296973
SGTC_629 3448-6466 76.7 µM 0.386908701534898 0.346154124386301 no 1160 0.349411899508446 1645 573744
SGTC_3354 9151612 71.43 µM 0.386535055899249 0.346310317317188 no 1161 0.349550222629634 1749 27261949
SGTC_2275 7947463 200 µM 0.386335737838801 0.346393647790629 no 1162 0.349624018085046 1690 1225414
SGTC_2744 captopril 92.04 µM 0.386163215514735 0.346465781562641 no 1163 0.349687897283757 1757 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1879 gemcitabine 100 µM 0.385334590609544 0.346812317704732 no 1164 0.349994768423886 1683 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1014 4130-3005 69.3 µM 0.384043716870511 0.347352424534406 no 1165 0.35047302297301 1619 743608
SGTC_2409 alverine citrate 63.97 µM 0.383595414502556 0.347540068677917 no 1166 0.350639169594979 1780 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_254 nsc-64875 3.808 µM 0.380558571143919 0.34881216993512 no 1167 0.351765413740219 1774 56993
SGTC_2781 5567276 71.43 µM 0.377801377312623 0.349968603311327 no 1168 0.352789075238491 1720 2853274
SGTC_1553 gossypol 38.6 µM 0.376855053010165 0.35036583611524 no 1169 0.353140662687561 1649 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_328 k915-0120 63.5 µM 0.376843504396373 0.350370684818767 no 1170 0.353144954114035 1760 6624543
SGTC_1758 st042942 75.2445 µM 0.376049200874506 0.350704232868066 no 1171 0.353440159451552 1693 669317
SGTC_80 0159-0065 512.242 µM 0.372724617879668 0.352101555625358 no 1172 0.354676706111799 1739 1548079
SGTC_2011 4012611 177 µM 0.372389685366141 0.352242438979464 no 1173 0.354801366245827 1621 2049887
SGTC_2305 7443522 69.23 µM 0.372151203406968 0.35234276449955 no 1174 0.354890137464859 1750 5415886
SGTC_1797 st048695 56.8 µM 0.3687414026009 0.353778333493891 no 1175 0.356160242614543 1772 592262 YIL048W NEO1
SGTC_562 3772-2733 112 µM 0.368315599089013 0.353957748744539 no 1176 0.356318961216056 1757 2876874 YIL048W NEO1
SGTC_2973 9094665 17.96 µM 0.367663700716608 0.354232493453284 no 1177 0.356562005080582 1782 25237061 YIL048W NEO1
SGTC_3218 9131285 49.47 µM 0.367034809643118 0.354497613585074 no 1178 0.356796526466694 1801 17156417
SGTC_201 4262-0159 12.803 µM 0.366867743589376 0.354568055087914 no 1179 0.35685883660285 1781 1341029
SGTC_203 k066-0004 30.888 µM 0.366195438935819 0.354851574966574 no 1180 0.357109622691193 1801 6795412
SGTC_570 0987-0065 62.6 µM 0.365654680817002 0.355079678265303 no 1181 0.357311383515993 1751 3104428
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.363980707118392 0.355786125026848 no 1182 0.357936208090709 1779 165506
SGTC_799 1310-0557 151 µM 0.363249846652316 0.356094716740188 no 1183 0.358209127343289 1697 5354492
SGTC_2442 5158906 48.48 µM 0.360937400856464 0.357071722580738 no 1184 0.359073121846274 1774 1893835
SGTC_1085 doxorubicin 7.67 µM 0.360776220537538 0.357139856131653 no 1185 0.359133370268116 1788 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1070 indatraline 8.81 µM 0.360746117761273 0.357152581571336 no 1186 0.359144622928265 1645 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2134 5324836 1.464 µM 0.360426696471633 0.357287621306668 no 1187 0.359264032704218 1717 699272
SGTC_3281 9140613 49.47 µM 0.360037782109592 0.357452064323041 no 1188 0.359409439746617 1587 16013766
SGTC_3139 9095020 49.47 µM 0.359925032380627 0.357499742765438 no 1189 0.359451598348187 1613 25236292
SGTC_112 phenothiazine 287.218 µM 0.359731252052284 0.357581691787884 no 1190 0.359524059349835 1836 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1615 st002656 86.5 µM 0.35941539936046 0.357715278858456 no 1191 0.359642178151845 1659 1584458
SGTC_892 0929-0076 29 µM 0.358621743734568 0.358051025300836 no 1192 0.35993903912436 1661 5751038
SGTC_3203 9113543 49.47 µM 0.357722883725945 0.358431409798358 no 1193 0.360275353053822 1737 17018012
SGTC_725 1497-0963 19 µM 0.357409586295066 0.358564025762735 no 1194 0.360392600620608 1832 3549977
SGTC_1271 0832-2808 169 µM 0.355382268455958 0.359422582701541 no 1195 0.361151615381975 1820 3663794
SGTC_2651 TUB2.036 5 µM 0.355311660982223 0.35945249736561 no 1196 0.361178060239929 1771 15992207 YFL037W TUB2
SGTC_1238 0333-0287 48.8 µM 0.353897493031887 0.360051827004467 no 1197 0.361707852944766 1679 7226
SGTC_1430 4049-0248 69.1 µM 0.353893867290773 0.360053364049999 no 1198 0.361709211605016 1792 22774488
SGTC_1263 0774-1208 64.8 µM 0.353613288044667 0.360172315717512 no 1199 0.361814357290515 1830 906585
SGTC_1050 3232-1156 69.3 µM 0.352935913994691 0.3604595444563 no 1200 0.362068242849314 1668 700529
SGTC_2158 5657123 3.6195 µM 0.351472049706168 0.361080539600912 no 1201 0.362617118852886 1744 2858827
SGTC_2707 st078556 66.6 µM 0.35089106988349 0.361327102368992 no 1202 0.362835035631 1826 17250899
SGTC_2103 5378138 10 µM 0.350773981541747 0.361376800618316 no 1203 0.362878959085271 1748 244142
SGTC_972 1319-0219 195 µM 0.350641209280415 0.361433158751324 no 1204 0.362928768244986 1666 23903702
SGTC_269 exalamide 29 µM 0.349981131432692 0.361713388054034 no 1205 0.363176429095502 1731 3316 A derivative of salicylamide.
SGTC_2055 5235184 200 µM 0.348681406981506 0.362265389488616 no 1206 0.363664252174719 1724 2836034
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.348326225844883 0.362416287127804 no 1207 0.36379760012913 1826 756377
SGTC_1333 1482-0047 286 µM 0.348303881693161 0.362425780688533 no 1208 0.363805989490481 1799 3811116
SGTC_3323 9138564 53.9225 µM 0.345930127342633 0.36343481988683 no 1209 0.364697613248612 1837 43912313 YNL103W MET4
SGTC_512 prima-1 270 µM 0.345688583852116 0.363537548841076 no 1210 0.364788382351514 1775 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2192 5915882 198.485 µM 0.345514406517695 0.363611632917544 no 1211 0.364853840776789 1709 2876149
SGTC_456 gingerol 170 µM 0.344712293152217 0.363952867249889 no 1212 0.365155337691326 1735 442793 A herb.
SGTC_1284 0929-0043 16 µM 0.344603475875488 0.363999168514674 no 1213 0.365196246158089 1688 1239883
SGTC_1336 1486-0901 104 µM 0.344433584750258 0.364071460398561 no 1214 0.365260117625925 1746 5006114
SGTC_958 1222-0007 33 µM 0.342668420850487 0.364822856785864 no 1215 0.36592396119478 1791 7312461
SGTC_1901 st060216 58.6 µM 0.340600655579885 0.365703725368669 no 1216 0.366702117923168 1667 688792
SGTC_1112 tnp00069 1.16933 µM 0.340181656702587 0.365882305498583 no 1217 0.366859865577404 1804 145826
SGTC_2285 7945142 200 µM 0.337384282535878 0.36707530815517 no 1218 0.367913615764073 1706 2970608
SGTC_213 1246-0773 967 nM 0.33591428770097 0.367702735941953 no 1219 0.368467751231267 1755 6251622
SGTC_3336 9143619 71.43 µM 0.335456119852259 0.367898364859084 no 1220 0.368640520116854 1810 45595730
SGTC_3006 9075424 71.4286 µM 0.334799523247643 0.368178778801419 no 1221 0.368888160086568 1667 7465181
SGTC_443 clozapine 122 µM 0.334155285835092 0.36845398275779 no 1222 0.369131191618403 1834 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_483 fpl-64176 144 µM 0.333307427422438 0.368816271945151 no 1223 0.369451116680244 1752 3423
SGTC_715 0868-0130 184 µM 0.332842741758444 0.369014881227354 no 1224 0.369626496345277 1879 2876258
SGTC_469 w7 172 µM 0.332191288769944 0.36929337480212 no 1225 0.369872410596634 1780 45115570 A P450 inhibitor.
SGTC_78 0336-0123 156.75 µM 0.331717161918323 0.369496105302296 no 1226 0.370051420218876 1675 6765896
SGTC_685 1278-0033 54.9 µM 0.331487441314174 0.3695943439117 no 1227 0.370138162828848 1811 3590572
SGTC_1655 st012546 55.1 µM 0.330894043167567 0.369848146379697 no 1228 0.370362260812755 1746 720985 YLR208W SEC13
SGTC_910 3454-3003 490 µM 0.330623086182324 0.369964056322874 no 1229 0.370464602893234 1825 820824
SGTC_3194 9111903 49.47 µM 0.3291963793956 0.37057456739763 no 1230 0.371003629695922 1784 17087251
SGTC_2186 6124449 200 µM 0.328154574035586 0.371020578967372 no 1231 0.371397396179458 1805 3834182 YLR033W RSC58
SGTC_1941 st076221 61.8 µM 0.327598568050705 0.371258683944753 no 1232 0.371607602387241 1870 2828568
SGTC_1648 st011736 69.8 µM 0.32709763932225 0.371473244747518 no 1233 0.37179701862304 1815 2855514
SGTC_3288 9119690 36.221 µM 0.322690999877008 0.373362437313396 no 1234 0.373464634440349 1687 17595618 YKL019W RAM2
SGTC_1845 st056753 3.01 µM 0.321016803745927 0.374080991869986 no 1235 0.374098828377592 1679 5375839
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.320321411020655 0.374379578911038 no 1236 0.374362346955215 1812 279621
SGTC_2828 7998861 71.43 µM 0.320189027136502 0.374436430316279 no 1237 0.374412520388976 1873 2988188
SGTC_1181 1222-0449 220 µM 0.319375975309268 0.374785650007678 no 1238 0.374720713285291 1821 658318
SGTC_2667 digitoxin 100 µM 0.318726598248037 0.375064642371358 no 1239 0.374966921634441 1863 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1340 1486-1359 257 µM 0.317735336680856 0.375490644870417 no 1240 0.375342852176531 1774 4309068
SGTC_2936 9038235 15.59 µM 0.317167134074575 0.375734902942402 no 1241 0.375558393331921 1727 4749415
SGTC_2994 9053520 71.4286 µM 0.317037438120295 0.375790663427358 no 1242 0.375607597455578 1857 4647384
SGTC_2910 7948405 25.97 µM 0.316403293725371 0.376063339939051 no 1243 0.375848208627819 1880 2971328
SGTC_1007 4101-0031 70 µM 0.316304919500818 0.376105645538469 no 1244 0.3758855387412 1862 1146276
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.315447156345252 0.37647458756399 no 1245 0.376211083715647 1768 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1849 st056239 19.2 µM 0.315287301873512 0.376543356832033 no 1246 0.376271762679027 1643 5393181
SGTC_1952 st077036 64.1 µM 0.315211912637545 0.376575790581939 no 1247 0.376300380648247 1733 2937007
SGTC_2303 7774051 200 µM 0.314439282882659 0.376908239416751 no 1248 0.376593712282961 1845 2953184
SGTC_1844 rapamycin 4 nM 0.313920608155059 0.377131467146866 no 1249 0.376790668980515 1775 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1001 4048-4355 44.4 µM 0.312624827314574 0.377689325868442 no 1250 0.377282856737662 1725 21824233
SGTC_2612 dictamnine 15.46 µM 0.312001882927231 0.377957606395049 no 1251 0.377519546173666 1764 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_548 1436-0017 110 µM 0.310780368160258 0.378483841193993 no 1252 0.37798379755422 1872 9677137
SGTC_1400 3771-8998 51.5 µM 0.308904788128299 0.37929228917129 no 1253 0.378696977212356 1820 670767
SGTC_868 0527-0199 213 µM 0.308278937444342 0.37956217286774 no 1254 0.378935045796721 1769 2849450
SGTC_860 0443-0016 25.1 µM 0.307662641870326 0.379827993497251 no 1255 0.379169524584188 1789 5337942
SGTC_2332 7982454 138.89 µM 0.307631378791821 0.37984147940401 no 1256 0.379181420271528 1772 2981748
SGTC_1332 1480-0653 17.5 µM 0.306238708083527 0.380442381679104 no 1257 0.379711451214958 1896 5749438
SGTC_1968 st069590 43.6 µM 0.3051431094418 0.380915307766686 no 1258 0.380128579642142 1859 6384066
SGTC_978 1416-0512 87.4 µM 0.304414286386046 0.381230010125395 no 1259 0.38040614249381 1793 6814003
SGTC_1618 st003135 44.5 µM 0.303693823334054 0.381541179888773 no 1260 0.38068058207893 1877 1270615
SGTC_1405 3909-7894 12 µM 0.30349496979745 0.381627078713456 no 1261 0.380756340169377 1862 7104060
SGTC_387 norethindrone acetate 66.7 µM 0.303033953892122 0.381826246317721 no 1262 0.380931992972304 1738 541197
SGTC_1798 st045719 60.953 µM 0.302765329950074 0.381942311378151 no 1263 0.381034353358489 1858 3980186
SGTC_3186 9110464 49.47 µM 0.302451758190764 0.382077810584933 no 1264 0.381153851847711 1853 17018021
SGTC_2279 7948423 32.93 µM 0.302372716916555 0.382111967822022 no 1265 0.38118397533151 1938 1247112
SGTC_1703 st026983 48.3 µM 0.302310283528718 0.382138948704112 no 1266 0.381207769879278 1884 1104023
SGTC_2143 5623677 140.463 µM 0.300200553767462 0.383051014001373 no 1267 0.382012091349276 1863 5375313
SGTC_1431 4049-0260 9.09 µM 0.300020907942682 0.383128707413951 no 1268 0.382080603801471 1838 3854841
SGTC_2622 2-methoxyxanthone 59.94 µM 0.299137284693428 0.383510926092035 no 1269 0.382417649458803 1914 71034 A hepatoprotective.
SGTC_637 1181-0519 7.26 µM 0.298207216068448 0.383913357594305 no 1270 0.38277250729616 1775 6252091 YGR060W ERG25
SGTC_2890 9046729 58.44 µM 0.297939428596588 0.38402924982221 no 1271 0.382874697034161 1715 903329
SGTC_2524 avocatin b 10.57 µM 0.297750300818729 0.384111106202222 no 1272 0.382946874547204 1882 6710748
SGTC_3098 9119039 49.47 µM 0.297730896210901 0.384119505001622 no 1273 0.382954280227324 1774 17161528
SGTC_2197 6588183 93.1375 µM 0.29741686044934 0.384255435094206 no 1274 0.383074136491493 1824 884136
SGTC_2165 5727197 32.143 µM 0.297223271551473 0.384339236965959 no 1275 0.38314802805659 1828 1361712
SGTC_1163 k060-0048 49.9 µM 0.294979939282076 0.385310736872517 no 1276 0.384004602178794 1773 6809982
SGTC_2273 7815444 169.05 µM 0.292893363259667 0.386214998391377 no 1277 0.384801830934304 1926 2824616
SGTC_2299 7976368 114.88 µM 0.290676377035231 0.387176453481955 no 1278 0.385649420122228 1894 2979718
SGTC_2742 clothiapine 36.27 µM 0.2901359668225 0.387410921966852 no 1279 0.38585611053591 1908 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3283 9109332 35.8195 µM 0.288877007885092 0.38795730729494 no 1280 0.386337749512148 1770 17027281
SGTC_1662 st014054 52 µM 0.288662888204462 0.388050256859387 no 1281 0.386419682569294 1861 2838777
SGTC_1031 k035-0009 16 µM 0.288656365268552 0.388053088572992 no 1282 0.386422178655142 1936 5180959
SGTC_2495 cafestol 54.53 µM 0.287962804811392 0.388354208491572 no 1283 0.386687605337393 1852 16667697 An anti-infammatory.
SGTC_1697 st025554 27.742 µM 0.283075553438862 0.390477976821004 no 1284 0.388559460502194 1780 1269519
SGTC_1088 bifonazole 369 nM 0.282498603210171 0.390728909261739 no 1285 0.388780608730327 1830 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1434 4073-0095 163 µM 0.28189450406561 0.390991698329667 no 1286 0.389012201919244 1893 24133745
SGTC_953 1188-0045 9.7 µM 0.281226128028994 0.391282506483215 no 1287 0.389268482865257 1846 6144426
SGTC_2775 cyproheptadine 69.59 µM 0.280997504744844 0.391381993661226 no 1288 0.389356156843297 1952 2913 A selective serotonin reuptake inhibitor.
SGTC_3117 9124945 49.47 µM 0.280731638811064 0.391497696200558 no 1289 0.389458119963741 1718 17592065
SGTC_1632 st005650 90 µM 0.280177197904379 0.391739014929281 no 1290 0.389670779899739 1815 2759605
SGTC_1754 st042065 16.137 µM 0.279471117924091 0.392046394407263 no 1291 0.389941649949739 1853 1126236 YIL048W NEO1
SGTC_3078 9116413 49.47 µM 0.278517131494842 0.392461802584322 no 1292 0.390307708032638 1807 17177322
SGTC_377 3970-0964 33.1 µM 0.278230482442608 0.392586646314341 no 1293 0.390417718347012 1858 16481235
SGTC_1628 st004252 77.7 µM 0.2778159354781 0.392767212733066 no 1294 0.390576828902794 1923 692968
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.27568011101964 0.393697890101553 no 1295 0.391396886494376 1858 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3104 9120930 49.47 µM 0.27548615317101 0.393782436666149 no 1296 0.391471381292145 1829 17014836
SGTC_2680 butyl paraben 22.24 µM 0.275307494083495 0.393860318904502 no 1297 0.391540003705813 1875 7184 An antifungal and steroid mimetic.
SGTC_616 4092-0450 108 µM 0.275169227308536 0.393920595976054 no 1298 0.391593113871778 1850 787165
SGTC_3193 9111931 49.47 µM 0.27503054945465 0.393981054809252 no 1299 0.391646383968529 1817 17087244
SGTC_426 0988-0037 14.6 µM 0.273498020946263 0.394649355010726 no 1300 0.392235206714305 1995 5383008
SGTC_3304 9125678 46.087 µM 0.27158847040088 0.395482499605855 no 1301 0.392969232818707 1786 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2898 9056270 58.44 µM 0.271556057132751 0.395496645780795 no 1302 0.392981695685526 1840 19154699
SGTC_1670 st016595 4.04 µM 0.271537307542801 0.395504828757468 no 1303 0.392988904932826 1930 597879
SGTC_253 dyclonine 31.25 µM 0.268332993215745 0.396903977422799 no 1304 0.394221506099936 1888 3180 An oral anasthetic.
SGTC_760 0568-0725 82.9 µM 0.268071225381799 0.397018336030733 no 1305 0.394322247139483 1952 3916171
SGTC_817 1391-0715 46 µM 0.267856546038253 0.397112129682768 no 1306 0.394404871506107 1789 1353946
SGTC_1852 st056254 31.4 µM 0.267599416562913 0.397224477678252 no 1307 0.394503840051998 1866 442583
SGTC_1957 st077035 62.4 µM 0.267321092144169 0.397346096025975 no 1308 0.394610974158037 1892 705593
SGTC_873 0591-4978 488 µM 0.267098927600572 0.397443181573456 no 1309 0.394696496629446 1994 3305145
SGTC_121 0557-0495 61.343 µM 0.266658811433448 0.397635530384672 no 1310 0.394865934785984 1807 3104427
SGTC_1365 1672-3266 55.4 µM 0.26647266740362 0.397716890450671 no 1311 0.394937603445531 1939 6415873
SGTC_1299 1079-1439 3.74 µM 0.266158600852265 0.397854173136978 no 1312 0.395058532538454 1807 323161
SGTC_2653 dihydrofissinolide 100 µM 0.260912008224056 0.400149386941302 no 1313 0.397080182142541 1877 6857746
SGTC_2843 9000894 45.46 µM 0.260210499071651 0.400456537862866 no 1314 0.397350703029277 1849 2242070
SGTC_3208 9114115 49.47 µM 0.260094713431327 0.400507239727912 no 1315 0.397395357852766 1710 650895
SGTC_1732 st034308 51.822 µM 0.258948929881628 0.401009061996192 no 1316 0.397837322383941 1781 830119
SGTC_1515 3460-0031 42.1 µM 0.257997960956154 0.401425684824809 no 1317 0.398204240445279 1910 2876596
SGTC_1483 3453-0561 55.9 µM 0.256868296704846 0.401920740332198 no 1318 0.398640222574314 1922 4546991
SGTC_2685 mycophenolic acid 18.85 µM 0.255393679483637 0.402567202156622 no 1319 0.399209526006462 1922 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.254188827005893 0.403095598946101 no 1320 0.399674840976959 1974 77254
SGTC_1555 citronellol 128 µM 0.253815645448597 0.403259296370501 no 1321 0.399818992925776 1992 8842 A terpine precursor.
SGTC_515 4092-1064 102 µM 0.252245638592701 0.403948170870016 no 1322 0.400425601896035 1996 717353
SGTC_3190 9110366 49.47 µM 0.249219765414287 0.405276677145643 no 1323 0.401595395550098 1993 17123768
SGTC_106 0092-0003 11.579 µM 0.247332167103029 0.406105979268281 no 1324 0.402325583097195 1980 1072148
SGTC_2009 4012297 12.05 µM 0.247321567811433 0.406110637180718 no 1325 0.402329684230476 1837 45595307
SGTC_1208 2323-2347 50.3 µM 0.247199720963638 0.406164184350158 no 1326 0.402376830621479 2006 5412760
SGTC_1366 1683-0113 21.9 µM 0.246590507944603 0.406431937179924 no 1327 0.402612575652744 1831 708623
SGTC_2846 9008642 19.48 µM 0.246058611604942 0.406665744642946 no 1328 0.402818430682385 1831 2992898
SGTC_1194 1488-0194 225 µM 0.245422109035401 0.406945577946981 no 1329 0.403064805923362 1877 1391452
SGTC_2417 cerulenin 830 nM 0.24382007939458 0.407650107550842 no 1330 0.403685084228286 1877 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2205 7238770 200 µM 0.243441018456458 0.407816852165685 no 1331 0.403831885608441 1976 279867
SGTC_2102 5377816 72.7585 µM 0.243414697452871 0.40782843109753 no 1332 0.4038420796169 1992 1379702
SGTC_2437 5741531 144.16 µM 0.242549375694908 0.408209141509665 no 1333 0.404177251242104 1996 2262990
SGTC_1983 st071813 46.9 µM 0.242184767906419 0.408369581779088 no 1334 0.404318498617217 1880 11838595
SGTC_3270 9137563 49.47 µM 0.238420011462326 0.410027100681146 no 1335 0.405777673986761 1955 17015724
SGTC_2435 5706476 10.6 µM 0.238185121992095 0.410130569693605 no 1336 0.405868758015395 2009 5725375
SGTC_2649 anisomycin 9.56 µM 0.237418654184271 0.410468242902735 no 1337 0.406166009720915 1907 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_621 3584-0052 32.1 µM 0.235861892604626 0.411154290113807 no 1338 0.406769919668879 2007 2273927
SGTC_1721 st082152 9.2685 µM 0.235107335176327 0.411486912964622 no 1339 0.407062712802888 1909 5296051
SGTC_532 1548-0774 215 µM 0.234608067382301 0.41170703442306 no 1340 0.40725647371752 1996 5932993
SGTC_244 nsc-207895 1.295 µM 0.234232307605364 0.411872720941908 no 1341 0.407402317358724 1870 42640
SGTC_192 3455-0609 60.9 µM 0.232111152132868 0.412808311479337 no 1342 0.408225841623904 1918 3769639
SGTC_2866 9034245 58.44 µM 0.22849761602176 0.414403293570937 no 1343 0.40962970462321 2034 6462273
SGTC_2246 7293507 91.5585 µM 0.226884342048691 0.415115835754978 no 1344 0.410256838909128 2043 887656
SGTC_3035 9091303 49.47 µM 0.226022816436707 0.41549646431363 no 1345 0.410591837260565 1925 25237002
SGTC_100 0086-0128 49.5915 µM 0.225870440014807 0.41556379363819 no 1346 0.410651094588216 1811 93297
SGTC_1602 st001878 87.6 µM 0.225637626121741 0.415666669997774 no 1347 0.410741637003233 1959 595405 YLR310C CDC25
SGTC_1629 st005085 44.9 µM 0.225464946215241 0.415742977941697 no 1348 0.410808796101366 1838 24207091
SGTC_3297 9117502 71.43 µM 0.225236203120078 0.415844065325232 no 1349 0.410897763459738 2021 7453720
SGTC_2934 9036370 36.88 µM 0.225049205974117 0.415926708250784 no 1350 0.4109704975507 1989 6462800
SGTC_1724 st037281 8.293 µM 0.224865132480773 0.416008062706599 no 1351 0.411042097452301 1852 574124 YDL195W SEC31
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.224150743572299 0.416323833268708 no 1352 0.411320004596236 1918 1377
SGTC_897 1000-0139 31.4 µM 0.22409721938475 0.416347493936185 no 1353 0.411340828037638 2020 6151020
SGTC_2580 diallyl disulphide 81.36 µM 0.223594109143742 0.416569911446274 no 1354 0.411536573925816 1875 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2710 st078562 53.7235 µM 0.222860992899988 0.416894058974291 no 1355 0.411821848019794 1944 17250908
SGTC_1511 0906-3109 28.5 µM 0.222392467188762 0.417101247343448 no 1356 0.412004187660865 1966 2882180
SGTC_2691 st077356 60.2 µM 0.222137553197984 0.417213983412464 no 1357 0.412103402420914 1966 2839272
SGTC_1223 0764-0573 147 µM 0.222072064233692 0.417242947097841 no 1358 0.412128892207298 1921 1609797
SGTC_3043 9092303 49.47 µM 0.221617229474518 0.417444118423524 no 1359 0.412305934407127 1830 25236084
SGTC_1439 4092-1168 46 µM 0.220118921643164 0.418106965674628 no 1360 0.412889269422814 1972 2886240
SGTC_996 3970-0799 1.8 µM 0.219214956325629 0.418506990096181 no 1361 0.413241302678124 2029 6615648 YGL040C HEM2
SGTC_2932 9016711 44.54 µM 0.218588868242341 0.418784097199166 no 1362 0.413485162484704 2052 7117328
SGTC_1977 st070720 65.3 µM 0.218477571002158 0.418833361672539 no 1363 0.413528515989295 1899 682188
SGTC_2766 oltipraz 83.91 µM 0.217766792980203 0.419148009570509 no 1364 0.413805409495811 2003 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_803 4488-1585 147 µM 0.217277035274078 0.419364846089771 no 1365 0.413996226401099 2012 747204
SGTC_2845 9003024 42.97 µM 0.216948463348255 0.419510332554917 no 1366 0.4141242543071 1996 2990173
SGTC_282 k297-0036 65.7 µM 0.21590325452759 0.419973207613682 no 1367 0.414531580092192 1977 5061378
SGTC_809 3998-0021 90 µM 0.215602928565965 0.42010622871663 no 1368 0.414648636412427 2053 715485
SGTC_1291 0993-0025 5.79 µM 0.215321424026853 0.420230921676664 no 1369 0.414758363697534 2006 4353356
SGTC_1876 myriocin 605 nM 0.214896557120523 0.420419132421711 no 1370 0.414923984603711 2041 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1098 clofazimine 15.1 µM 0.214683028751243 0.420513729701695 no 1371 0.415007227586829 2000 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1406 3909-7906 11.9 µM 0.214473642145478 0.420606496556888 no 1372 0.415088859629575 1975 X1406
SGTC_2277 7947813 106.88 µM 0.213394127382055 0.421084835736407 no 1373 0.415509780345599 2016 1246798
SGTC_1572 epiandrosterone 68.9 µM 0.212728778512168 0.421379713716425 no 1374 0.415769259242537 1957 441302 A steroid.
SGTC_738 1315-0003 72.4 µM 0.211319098197451 0.422004619706487 no 1375 0.416319140600968 2028 6251474
SGTC_784 4579-0127 173 µM 0.211265436501027 0.422028411625832 no 1376 0.416340075942523 2041 1948547
SGTC_1982 st072467 71.9 µM 0.210412212698548 0.422406742573942 no 1377 0.416672980826984 1896 3163533
SGTC_2432 5630864 12.22 µM 0.208878606541296 0.423086944021883 no 1378 0.417271502646204 1918 5714970
SGTC_1807 st050092 58.9 µM 0.208870393824382 0.423090587233302 no 1379 0.417274708347836 1946 5008496
SGTC_1433 4060-0023 7.6 µM 0.207239519758779 0.423814182867965 no 1380 0.417911402444297 2002 3840627
SGTC_3213 9129884 49.47 µM 0.206928827825785 0.423952061674276 no 1381 0.418032721195277 1866 17190742
SGTC_2961 9083290 32.55 µM 0.206290806986195 0.424235231610443 no 1382 0.418281879533035 2022 17741490
SGTC_489 paxilline 115 µM 0.20613732102435 0.424303358440912 no 1383 0.418341823392872 1926 105008 A toxic potassium channel blocker.
SGTC_3089 9117425 49.47 µM 0.205943640715266 0.424389329306316 no 1384 0.418417467839887 1878 9401657
SGTC_3152 9099253 49.47 µM 0.205793502946157 0.424455974973348 no 1385 0.418476108239061 2000 25236131
SGTC_1122 capsaicin 818.572 nM 0.205451728845869 0.424607695435918 no 1386 0.418609604187071 1979 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_690 glyoxal 20.3 µM 0.205191347914914 0.4247232913163 no 1387 0.418711314497106 1970 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_3246 9135460 32.98 µM 0.205124100623862 0.424753146743062 no 1388 0.418737583597451 2000 41446951
SGTC_1657 st012939 43.4 µM 0.20452515045457 0.425019078529608 no 1389 0.418971570067571 2047 24207257
SGTC_1607 st000305 50.6 µM 0.202624008150634 0.425863404579054 no 1390 0.419714461723892 2040 5457690
SGTC_712 r015-0009 80.6 µM 0.20253723894683 0.425901948237176 no 1391 0.419748374566335 1995 6813872 YLR060W FRS1
SGTC_2349 9023730 187.07 µM 0.20206026800407 0.426113835637664 no 1392 0.419934804343319 2032 4126287
SGTC_2760 etidronate 98.04 µM 0.201164290844518 0.426511918078623 no 1393 0.420285056239914 1931 3305 A chelator and antioxidant.
SGTC_1315 1237-0019 3.69 µM 0.198952231627069 0.427495055274887 no 1394 0.421150055585523 2061 825140
SGTC_1356 1502-0781 85.8 µM 0.198177582379839 0.427839450544481 no 1395 0.421453063151167 1940 567702
SGTC_216 k038-0035 28.382 µM 0.197883422805794 0.427970243073954 no 1396 0.421568137198649 2037 4444231 YPR107C YTH1
SGTC_2536 dehydroabietamide 32.04 µM 0.196953932527518 0.42838357541614 no 1397 0.421931794052233 2042 3983547
SGTC_855 0428-0020 25 µM 0.196205952809016 0.428716249432901 no 1398 0.422224484474386 1945 6812414
SGTC_474 dl-dihydrosphingosine 5 µM 0.195686626353953 0.428947256650126 no 1399 0.422427726329633 2042 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_3269 9137823 49.47 µM 0.195618980900819 0.428977348549164 no 1400 0.422454201348327 1897 17682936
SGTC_2076 5212012 200 µM 0.194906227804846 0.429294439915901 no 1401 0.422733179306459 2021 604802
SGTC_118 0083-0097 135.343 µM 0.194248706203069 0.429587000226197 no 1402 0.422990573534816 1939 5207356
SGTC_1212 0520-0165 585 µM 0.194195651802397 0.429610608153274 no 1403 0.4230113437117 2087 5403258
SGTC_1935 st074532 41.6 µM 0.193728741530037 0.429818382795079 no 1404 0.423194142840679 2086 2829742
SGTC_2645 abamectin 100 µM 0.192314327405173 0.43044791418464 no 1405 0.423747998111418 2036 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_3174 9107204 49.47 µM 0.191552577638987 0.430787029256025 no 1406 0.424046346033526 2040 3938802
SGTC_1766 st045414 44.774 µM 0.191017344717416 0.43102533430958 no 1407 0.424256002120397 1997 253960
SGTC_1666 st014829 29 µM 0.189822545287776 0.431557392705152 no 1408 0.42472409425283 1939 3858230
SGTC_2618 avocadyne 43.43 µM 0.187768315106638 0.432472455647872 no 1409 0.425529137411336 1996 3015189
SGTC_864 0469-0573 172 µM 0.187227961657456 0.432713218085059 no 1410 0.425740951116702 1898 689425
SGTC_2347 9049783 174.81 µM 0.187082770894466 0.432777914229668 no 1411 0.425797868248676 2035 6467988 YPL169C MEX67
SGTC_2533 agelasine 13.65 µM 0.186162705602979 0.433187931698372 no 1412 0.426158584645806 2094 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2950 9072895 21.46 µM 0.183912527423854 0.434191002252261 no 1413 0.427041038489848 1922 17332245
SGTC_172 1112-0046 2.638 µM 0.183885005404337 0.434203273485396 no 1414 0.427051834088109 1974 2802135 YIL048W NEO1
SGTC_2304 7443016 91.4 µM 0.18336454578171 0.434435342557013 no 1415 0.427255996280283 1987 939854
SGTC_1376 2910-0861 41.3 µM 0.182227183866271 0.434942562301586 no 1416 0.42770222025036 2029 1112859
SGTC_1188 1403-0014 4.57 µM 0.181523646130304 0.435256366777592 no 1417 0.42797828726116 1961 9614867
SGTC_2002 4023503 131 µM 0.180732406730472 0.435609338229194 no 1418 0.42828881037435 2147 4736863 YCR052W RSC6
SGTC_763 3453-1109 128 µM 0.180116557643092 0.435884103681 no 1419 0.428530532034641 2097 1560353
SGTC_2549 cedrol 20.94 µM 0.180113646045491 0.435885402784594 no 1420 0.428531674904679 2077 6708665 A sedative which affects the nervous system.
SGTC_2847 9005661 71.43 µM 0.17955717269679 0.436133704081502 no 1421 0.428750114679345 2116 2991449
SGTC_311 1315-0136 58 µM 0.178740853569635 0.436497995435765 no 1422 0.429070594598988 2077 6759207
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.177781679684761 0.436926106100254 no 1423 0.429447217817569 2002 364106
SGTC_336 4111-0029 111 µM 0.177714519437019 0.436956084687817 no 1424 0.429473590950349 1967 3131175
SGTC_65 0798-0905 34.986 µM 0.177174735472705 0.437197043341547 no 1425 0.429685569937078 2103 3602145
SGTC_297 0986-0032 24 µM 0.176801402089352 0.437363712370467 no 1426 0.429832193848472 1983 2847425
SGTC_81 0411-0046 9.971 µM 0.174998325735709 0.43816882443321 no 1427 0.430540474577393 2030 12925265
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.174130413500751 0.438556457237967 no 1428 0.430881485897847 2003 7104
SGTC_2954 9074818 52.69 µM 0.172950614224242 0.439083481594334 no 1429 0.431345123331554 2017 16648742
SGTC_2589 lobaric acid 100 µM 0.172842943230277 0.439131584351529 no 1430 0.431387440591681 1952 73157 A novel microtubule depolymerizer.
SGTC_2307 7538926 6.34 µM 0.172348415384328 0.439352529603196 no 1431 0.431581811898691 1969 96582
SGTC_3226 9131256 49.47 µM 0.171876141394769 0.439563549911743 no 1432 0.43176745192259 2060 17178073
SGTC_700 3453-2283 142 µM 0.171861905094386 0.439569911207587 no 1433 0.431773048118438 2066 565664
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.17139481935475 0.439778630717738 no 1434 0.43195666403172 2093 88881 An O-methylated flavonoid and antioxidant.
SGTC_2181 6316240 54.2555 µM 0.170452395238209 0.440199808369572 no 1435 0.432327184761588 1964 12779990
SGTC_2511 berberine 10.47 µM 0.168982294886227 0.440856944134814 no 1436 0.432905283877523 1972 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2975 9084847 53.72 µM 0.168714813773517 0.440976525925227 no 1437 0.433010483057345 1955 27211724
SGTC_1733 st037357 54.9 µM 0.168357028224514 0.441136488197738 no 1438 0.433151206007519 1874 1272339 YGL099W LSG1
SGTC_1700 st030840 7.9285 µM 0.168128406263383 0.441238707777069 no 1439 0.433241131230878 2125 5499307
SGTC_1609 st001574 46.4 µM 0.167840459091049 0.441367457928273 no 1440 0.433354396107036 1974 3960012
SGTC_2088 5278280 127.392 µM 0.16592054892662 0.442226067316564 no 1441 0.434109737966488 2029 791502
SGTC_2082 5219693 150 µM 0.164186376679175 0.443001845708683 no 1442 0.434792212702703 2054 2834649
SGTC_2153 5569715 200 µM 0.164128108151843 0.443027915826435 no 1443 0.434815147373499 2081 2054701
SGTC_212 3807-4682 38.772 µM 0.16391915984857 0.443121404116696 no 1444 0.434897391868504 2086 3125501 YBL034C STU1
SGTC_306 1672-3436 11.6 µM 0.162916049506148 0.443570262820604 no 1445 0.435292266988706 2049 6797378
SGTC_301 4119-0100 24.5 µM 0.16240607297538 0.443798488252908 no 1446 0.435493044392861 2004 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_927 2425-1185 123 µM 0.161313261162237 0.444287607647127 no 1447 0.435923339574095 1957 730375
SGTC_2350 9023895 38.85 µM 0.16031061031005 0.444736447574478 no 1448 0.436318200576573 2058 2997209
SGTC_652 0437-0092 114 µM 0.159884870072428 0.444927053049682 no 1449 0.436485883562065 2045 3091274
SGTC_1992 st073643 23.3 µM 0.158017249536688 0.445763343530344 no 1450 0.4372216031594 2096 3161292
SGTC_1016 4226-1401 38 µM 0.157706750656078 0.44590240344206 no 1451 0.437343940406753 2124 2901613
SGTC_1109 tnp00067 928.257 nM 0.157350049938141 0.446062163504065 no 1452 0.437484488673909 1984 676295
SGTC_528 3492-0019 172 µM 0.157073748376209 0.446185920199293 no 1453 0.437593363251785 2138 2869262
SGTC_1880 MG-132 525 µM 0.156838545559307 0.446291272715497 no 1454 0.437686046898029 2127 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1240 0356-0016 42.1 µM 0.156745204464096 0.446333083296871 no 1455 0.437722829688826 2035 4305613
SGTC_682 0kpi-0099 17 µM 0.155631603262313 0.446831948211135 no 1456 0.438161706331061 1991 1714895 YML126C ERG13
SGTC_2702 st077768 96.8 µM 0.155134833628215 0.447054515515317 no 1457 0.438357510670064 2005 6484119
SGTC_3245 9134821 49.47 µM 0.154622726939759 0.447283971723257 no 1458 0.438559375984957 1986 17014901
SGTC_1948 st076329 66.6 µM 0.154513397273644 0.447332960621508 no 1459 0.438602474287014 2138 24208413
SGTC_3156 9099931 49.47 µM 0.154314621508032 0.447422030963545 no 1460 0.43868083455441 2033 18111053
SGTC_2731 amoxapine 43.43 µM 0.153491030963593 0.447791105622288 no 1461 0.439005531377058 2176 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_115 0527-0192 112.043 µM 0.153006840208782 0.448008106574492 no 1462 0.439196440551737 2008 4233931
SGTC_932 2857-0803 154 µM 0.152972164940261 0.44802364767204 no 1463 0.439210113034874 2137 674898
SGTC_2825 7998094 58.44 µM 0.152353204571767 0.44830107272219 no 1464 0.439454181736361 2050 2987815
SGTC_2080 5212524 12.4 µM 0.15227867596397 0.448334478996929 no 1465 0.439483571441353 2172 260183
SGTC_3234 9132280 49.47 µM 0.151190917024943 0.448822091386002 no 1466 0.439912557548388 2042 17612295
SGTC_865 0488-0499 301 µM 0.151029346585789 0.44889452557887 no 1467 0.439976283095331 2171 9634651
SGTC_117 lucigenin 22.078 µM 0.150873884697822 0.448964222834447 no 1468 0.44003760081579 1912 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2502 avocadyne acetate 18.59 µM 0.150250916615302 0.449243529996196 no 1469 0.440283328074961 2149 3952079
SGTC_1590 st077108 57.8 µM 0.150025196716005 0.449344737518639 no 1470 0.440372368064871 2140 5489485
SGTC_1625 st003711 30.1 µM 0.149946179112364 0.449380167942722 no 1471 0.440403538943192 2099 24207034 YER133W GLC7
SGTC_135 0933-0004 26.348 µM 0.149882205086236 0.449408853325905 no 1472 0.440428775698943 1989 21230617 YGL099W LSG1
SGTC_2438 5259590 200 µM 0.149786253080314 0.449451877845869 no 1473 0.440466627722707 2128 1201127
SGTC_422 cantharidin 155 µM 0.14963262294326 0.449520766261033 no 1474 0.440527234275199 1956 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1888 azatryptophan 97.5 µM 0.14962894209575 0.449522416787581 no 1475 0.440528686373782 2033 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2864 9034755 47.6 µM 0.148740769836802 0.449920707022883 no 1476 0.440879094686928 2178 4930451
SGTC_1508 1080-0625 72.9 µM 0.147555788548539 0.450452176210507 no 1477 0.441346674340509 2150 767111
SGTC_1422 4031-0024 15.5 µM 0.147200273360258 0.450611643668964 no 1478 0.441486972419055 2147 782427
SGTC_2107 5363541 170.161 µM 0.147167579959995 0.450626308797425 no 1479 0.441499874687487 2150 244052
SGTC_2268 7933382 153.85 µM 0.14658797708123 0.450886309771913 no 1480 0.441728622030635 2163 935025 YOR257W CDC31
SGTC_270 tamoxifen 5.46 µM 0.145279836731987 0.451473198788634 no 1481 0.442244966888438 2166 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_3034 9090421 49.47 µM 0.144968346633355 0.451612962565933 no 1482 0.442367931734909 2152 17173761
SGTC_2263 7948595 193.29 µM 0.143661055796463 0.452199601493988 no 1483 0.442884062545336 1997 2971371
SGTC_1916 st067606 49.2 µM 0.142693336913208 0.452633926843928 no 1484 0.443266189619832 2117 19590279
SGTC_495 decylubiquinone 155 µM 0.142662651830502 0.452647699654754 no 1485 0.443278307227728 2003 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.141476252312197 0.453180251315648 no 1486 0.443746859622009 2111 688751
SGTC_2262 9014885 67.46 µM 0.141204588457961 0.453302207818702 no 1487 0.443854160665929 2131 6457424
SGTC_574 1315-0397 40 µM 0.140216983840967 0.453745604546705 no 1488 0.444244276652633 2138 6794277
SGTC_1264 0783-0040 158 µM 0.139499465013782 0.454067779272709 no 1489 0.44452773933186 2015 2855798
SGTC_1768 st044301 37.178 µM 0.139469974666613 0.454081021447255 no 1490 0.444539390383768 2036 3931349
SGTC_2232 chlorophetanol 41.5365 µM 0.139438450576225 0.454095176898512 no 1491 0.44455184498032 2162 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1066 ketoconazole 628 nM 0.137192445092891 0.455103863199703 no 1492 0.445439341194605 2124 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2090 5301565 104.445 µM 0.136628155598211 0.455357332691311 no 1493 0.445662360122621 2064 2056344
SGTC_1594 piperine 70.1 µM 0.136464504352445 0.45543084552364 no 1494 0.445727041713392 2028 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2553 4-methylesculetin 85.09 µM 0.135851393111885 0.455706271236506 no 1495 0.445969380900995 2011 5319502
SGTC_1803 st050068 52.4 µM 0.135768642318319 0.455743446705307 no 1496 0.446002090640908 2168 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1669 st015249 58.4 µM 0.135637425165866 0.455802396289597 no 1497 0.446053958920106 2205 722793
SGTC_1962 st076595 64.5 µM 0.135586264365119 0.45582538065165 no 1498 0.446074182309166 2112 279619
SGTC_1123 mangostin 811.285 nM 0.135242960824425 0.455979616086325 no 1499 0.446209890634697 2014 5281650 An antioxidant.
SGTC_925 2064-1272 59.6 µM 0.134669187162959 0.456237409262178 no 1500 0.446436718149718 1974 6815817
SGTC_3166 9102297 49.47 µM 0.134517089987617 0.456305748733731 no 1501 0.446496849024757 2032 25237072
SGTC_1443 4112-3303 14 µM 0.134303790704817 0.456401589378587 no 1502 0.446581177926044 2110 704433
SGTC_1990 st072050 59.8 µM 0.133859779569556 0.456601102695816 no 1503 0.446756727616216 2013 17233948
SGTC_1816 st051957 91.6 µM 0.133797447516977 0.456629112047304 no 1504 0.446781372817287 2112 674121
SGTC_427 1354-0053 47.3 µM 0.13353544673807 0.456746846317016 no 1505 0.446884966420319 2125 6813657
SGTC_1407 3909-7909 12.3 µM 0.132621483241723 0.457157580192512 no 1506 0.447246370666011 2093 4411780
SGTC_2824 7998404 51.95 µM 0.132449514834897 0.457234867675479 no 1507 0.447314376222508 2087 837851
SGTC_1477 0139-0234 16 µM 0.13242054656212 0.457247886998725 no 1508 0.447325831987969 2177 620880
SGTC_2000 st075254 36.4 µM 0.131737926189906 0.457554692970967 no 1509 0.447595793085778 2162 17234175
SGTC_2116 5511452 16.8835 µM 0.131260771328306 0.457769166825533 no 1510 0.447784511590868 2096 870744
SGTC_1435 4092-0789 56.7 µM 0.130751080338907 0.457998278757832 no 1511 0.447986111446241 2183 2248285
SGTC_1764 st044502 93.5 µM 0.130282084199573 0.458209110220994 no 1512 0.44817162699612 2070 8407
SGTC_2774 tamoxifen 10.92 µM 0.130006811150791 0.458332861324273 no 1513 0.44828051895468 2150 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_698 k064-0052 127 µM 0.129242140889794 0.458676645840721 no 1514 0.448583026100573 2181 5088751
SGTC_2485 5633444 17.78 µM 0.129214244616079 0.458689188181538 no 1515 0.44859406256375 2046 5724239
SGTC_657 3534-0529 86.7 µM 0.128620365514135 0.458956209713239 no 1516 0.448829025405902 2171 1049549
SGTC_332 4112-0506 40.9 µM 0.128258176235011 0.459119067337622 no 1517 0.448972331102064 2072 2790355
SGTC_2065 5221596 34.26 µM 0.125830111665901 0.460211017145271 no 1518 0.449933202773169 2118 788581
SGTC_1892 st058411 7.36 µM 0.122844824526624 0.461553971763595 no 1519 0.451114989105223 2181 3934738
SGTC_913 3487-1245 167 µM 0.122707463346142 0.461615775427632 no 1520 0.451169376819393 2086 4016153
SGTC_1447 4239-0816 81.9 µM 0.12251454562625 0.461702577512814 no 1521 0.451245763512901 2021 1341554
SGTC_2736 butenafine 14.65 µM 0.122268472460652 0.461813299195312 no 1522 0.451343199979054 2160 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_582 0987-0078 156 µM 0.11941784346082 0.463096165548721 no 1523 0.452472162705958 2201 1625765
SGTC_3151 9099821 49.47 µM 0.119329428923548 0.46313596088104 no 1524 0.452507184579998 2100 17174189
SGTC_985 1493-0307 8.71 µM 0.118602238109003 0.463463283007044 no 1525 0.452795246057764 2198 3278274
SGTC_207 4185-0010 4.486 µM 0.118535423019586 0.463493358967035 no 1526 0.452821714710769 2198 3761753
SGTC_734 2023-0417 80 µM 0.118069551904569 0.463703070695233 no 1527 0.453006274364424 2154 3935732
SGTC_751 0833-0568 350 µM 0.117047363142782 0.464163243890571 no 1528 0.453411260519094 2110 6954252
SGTC_2546 rhodinyl acetate 100 µM 0.11599816825667 0.464635624671126 no 1529 0.453826996757961 2213 6708682
SGTC_1310 1188-0297 994 nM 0.114227521447419 0.46543293867189 no 1530 0.454528717865331 2134 1588352
SGTC_1695 st026914 34.495 µM 0.113827802671606 0.465612949488415 no 1531 0.45468714924215 2092 3289191
SGTC_2953 9074162 66.49 µM 0.113579262612659 0.465724881478314 no 1532 0.45478566349662 2220 16451992
SGTC_3266 9136860 49.47 µM 0.113518319597238 0.465752328063726 no 1533 0.45480982001019 2196 4871271 YPR165W RHO1
SGTC_1619 st003326 88.7 µM 0.113280584411176 0.465859397165454 no 1534 0.454904054772223 2218 2849032
SGTC_791 1348-1292 225 µM 0.113118297864914 0.465932487785903 no 1535 0.454968384251176 2170 5437054
SGTC_187 1488-2104 32.728 µM 0.110948328248628 0.466909908214521 no 1536 0.455828660869004 2184 2852859
SGTC_1251 0490-5699 265 µM 0.108650413300879 0.467945176575553 no 1537 0.456739886686114 2205 3883818
SGTC_446 go6976 132 µM 0.108108269456395 0.468189457858703 no 1538 0.456954904262588 2222 3501 A protein kinase C inhibitor.
SGTC_231 b-estradiol 524 µM 0.10757287080419 0.468430711622976 no 1539 0.457167259023034 2112 450 A steroid.
SGTC_383 2324-0395 7.37 µM 0.107557395945977 0.46843768485742 no 1540 0.457173396986438 2161 3146421
SGTC_2022 5136654 200 µM 0.105817121362382 0.469221943471288 no 1541 0.45786372608815 2120 1713771
SGTC_313 3474-0040 5.03 µM 0.103941257080164 0.470067439552447 no 1542 0.45860798299664 2185 1043375 YIL048W NEO1
SGTC_2844 9010103 25.97 µM 0.103572510258351 0.470233658397595 no 1543 0.45875430197247 2108 2480525
SGTC_3126 9127922 49.47 µM 0.103524706571182 0.470255207095713 no 1544 0.458773270915862 2155 45595682
SGTC_2569 tetrandrine 100 µM 0.103364887225547 0.470327250263321 no 1545 0.458836689385631 2042 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_508 roscovitine 141 µM 0.102530151169401 0.470703547284162 no 1546 0.459167940889301 2223 160355 A CDKinase inhibitor.
SGTC_2543 pimpinellin 60.67 µM 0.102460196638387 0.470735083812402 no 1547 0.459195702504277 2092 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_366 0181-0206 4.31 µM 0.102242339808936 0.470833298040206 no 1548 0.459282160757452 2232 274874
SGTC_10 0279-0212 42.575 µM 0.101967540523331 0.470957185598714 no 1549 0.45939121983322 2223 39851 YBR002C RER2
SGTC_2638 epoxomicin 18 µM 0.101785807880214 0.471039117536482 no 1550 0.459463345404843 2224 9915668 A protesome inhibitor.
SGTC_2737 bleomycin 30.5 nM 0.101692935099472 0.471080988566445 no 1551 0.459500205024155 2188 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_449 xestospongin c 11.1929 µM 0.101344246255958 0.471238195290918 no 1552 0.459638596770934 2164 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_3052 9092717 49.47 µM 0.101072288523433 0.471360810827146 no 1553 0.459746537963565 2142 25237534
SGTC_478 N-arachidonylglycine 10 µM 0.100845121983647 0.471463233776793 no 1554 0.45983670361396 2230 5283389
SGTC_1361 1608-0041 5.61 µM 0.100224069046311 0.471743258544959 no 1555 0.460083218941453 2165 X1361
SGTC_1829 berberine 14.4 µM 0.099980253822987 0.471853195514139 no 1556 0.460180001025978 2232 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2805 7950783 58.44 µM 0.0999329236864784 0.471874537054489 no 1557 0.460198788925778 2151 1178958 YDL195W SEC31
SGTC_1202 1988-0068 29.6 µM 0.0976990402442438 0.472881903902147 no 1558 0.461085638843212 2088 2850480
SGTC_2278 7948257 134.34 µM 0.09519565986935 0.474011005861718 no 1559 0.462079708627704 2262 1247028
SGTC_1474 0330-0125 5.35 µM 0.0951127373396157 0.474048410109532 no 1560 0.462112640504919 2237 X1474
SGTC_565 1418-0001 44.5 µM 0.0939500090884113 0.474572911246728 no 1561 0.462574433987627 2225 2862145
SGTC_3302 9125395 16.351 µM 0.0938790046100047 0.474604942463485 no 1562 0.462602636031427 2141 17599668
SGTC_2170 morpholine 200 µM 0.0931510638839017 0.474933337198283 no 1563 0.462891775319827 2201 121171 Reacts with secondary amines.
SGTC_2146 5545642 200 µM 0.0922135619711549 0.475356295995238 no 1564 0.463264181530627 2225 825326
SGTC_1037 k284-1091 78.7 µM 0.0907212333894983 0.476029624786942 no 1565 0.463857049198985 2236 3334711
SGTC_1294 1000-1494 117 µM 0.088065177509352 0.477228187748791 no 1566 0.464912436567217 2156 712797 YDL207W GLE1
SGTC_1504 k297-0033 30 µM 0.0877327378425907 0.477378218098814 no 1567 0.465044549451241 2200 4388117
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.0870864135333923 0.477669914055478 no 1568 0.465301412391691 2237 688662
SGTC_2318 6029776 164 µM 0.0859773036055807 0.478170499968726 no 1569 0.465742229751889 2207 818325
SGTC_1925 st057770 10.1 µM 0.0858114632625067 0.478245353363964 no 1570 0.465808146864283 2035 5989122
SGTC_2689 tacrolimus 100 µM 0.0855014163917231 0.478385297611345 no 1571 0.465931384739443 2170 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_355 1311-2252 105 µM 0.084723557765916 0.478736407315413 no 1572 0.466240583456294 2147 5338538
SGTC_551 k048-0028 34.9 µM 0.0837972472648738 0.479154546707999 no 1573 0.466608818343985 2241 6836383
SGTC_2068 5226020 147 µM 0.0834948322383545 0.479291062765802 no 1574 0.466729043161219 2211 1810509
SGTC_3178 9107506 49.47 µM 0.0832683998378468 0.479393280371453 no 1575 0.466819063143011 2215 8897194
SGTC_1274 0865-0114 173 µM 0.0825876185843402 0.479700611264503 no 1576 0.467089723289307 2187 870624
SGTC_1111 tnp00062 510.699 nM 0.0823227782505527 0.479820173667954 no 1577 0.467195020735316 2239 676306
SGTC_536 3852-0578 10.6 µM 0.0814398587040781 0.480218781535719 no 1578 0.467546075853142 2241 2869208
SGTC_2885 9057732 51.95 µM 0.0803160788939008 0.480726158104439 no 1579 0.467992935208767 2195 6471414
SGTC_2322 7413319 38.22 µM 0.0802792366559472 0.480742792579638 no 1580 0.468007585827477 2187 1840400
SGTC_276 colchicine 750 µM 0.0798693853834905 0.480927844961871 no 1581 0.468170569472091 2173 2833 A microtubule depolymerizer.
SGTC_101 0490-5701 117.494 µM 0.0790180206946847 0.481312258624777 no 1582 0.46850914471943 2266 4661669
SGTC_2291 7917025 104.35 µM 0.07879292518121 0.48141389811881 no 1583 0.468598665720298 2210 2964612
SGTC_2504 purpurogallin 52.29 µM 0.0787764525851529 0.481421336192541 no 1584 0.468605216971852 2110 5281571 An antioxidant.
SGTC_2124 5246320 200 µM 0.0766325135954309 0.482389469561485 no 1585 0.469457946444093 2212 579342
SGTC_2537 larixol 68.93 µM 0.076496221268368 0.482451018330712 no 1586 0.469512160079766 2246 6708759
SGTC_1261 0712-0010 12.7 µM 0.0762417788750177 0.482565924054902 no 1587 0.4696133723311 2244 2840123
SGTC_866 0495-0101 262 µM 0.0761380690124822 0.482612759657037 no 1588 0.469654626667464 2078 635694
SGTC_977 1348-1378 135 µM 0.0760951124608693 0.482632159000584 no 1589 0.469671714279801 2275 X977
SGTC_1141 3253-0389 52.6 µM 0.0756076445903077 0.482852304231335 no 1590 0.469865627186334 2257 5402031
SGTC_2155 5570423 76 µM 0.0749418013067905 0.483153013967836 no 1591 0.470130508708352 2174 797402
SGTC_2888 9058547 12.99 µM 0.0738399768498065 0.483650643533615 no 1592 0.470568858453389 2256 16476514
SGTC_2281 7943571 200 µM 0.0728236175581651 0.484109696090003 no 1593 0.470973238379362 2307 1244024
SGTC_291 SEC14.278 35.5 µM 0.0728232031833486 0.484109883252386 no 1594 0.470973403253233 2267 1068044
SGTC_3022 9087993 49.47 µM 0.0726763056013218 0.484176233309475 no 1595 0.471031852033841 2282 17173644
SGTC_724 3910-0327 137 µM 0.0725450178711723 0.484235533147817 no 1596 0.471084090370284 2210 2885483
SGTC_1696 st025591 34.7925 µM 0.0721689615761876 0.484405391597146 no 1597 0.471233722909024 2286 2787147
SGTC_2927 9011802 47.9 µM 0.0718336599656644 0.484556844212626 no 1598 0.471367142612454 2173 43912568
SGTC_222 nsc-310342 10.666 µM 0.0708981359628535 0.484979423405276 no 1599 0.471739413465133 2289 432556
SGTC_3128 9127691 49.47 µM 0.0703470492488701 0.485228358967578 no 1600 0.471958717674837 2203 41316314
SGTC_2740 felodipine 17.08 µM 0.0702729927134372 0.485261812048213 no 1601 0.471988189022063 2293 3333 L-type calcium channel blocker
SGTC_1253 0550-0034 176 µM 0.0700756672396639 0.485350949116298 no 1602 0.4720667169054 2220 5969915
SGTC_1413 3910-0535 34.4 µM 0.0700536249668677 0.48536090623191 no 1603 0.472075488942324 2249 2876951
SGTC_3004 9076122 71.4286 µM 0.0697617958052427 0.485492734543819 no 1604 0.472191627795732 2271 44782551
SGTC_673 1082-0474 110 µM 0.0697055885477723 0.485518125293321 no 1605 0.472213996793183 2256 3098046
SGTC_519 k048-0011 62.8 µM 0.0696903881379633 0.485524991850814 no 1606 0.47222004616812 2175 6836379
SGTC_2769 toremifene 3.73 µM 0.0696896303864662 0.485525334153817 no 1607 0.472220347734033 2243 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1457 k015-0032 57.3 µM 0.0695558050368499 0.485585787938248 no 1608 0.472273607084959 2307 4302660
SGTC_3330 9141424 71.43 µM 0.0694701137505269 0.485624497987281 no 1609 0.472307710467859 2265 27261020
SGTC_2450 5739737 12.93 µM 0.0693559958346995 0.485676049648186 no 1610 0.472353127384249 2202 2262825
SGTC_1282 0886-0010 32.4 µM 0.068567305895788 0.486032339171457 no 1611 0.472667021855352 2277 2836211 YNL267W PIK1
SGTC_3021 9087658 49.47 µM 0.0684460207366292 0.486087130560526 no 1612 0.472715294225239 2289 25237042
SGTC_1871 st057448 67.3 µM 0.0677625363214771 0.486395904137843 no 1613 0.472987333433906 2266 691747
SGTC_347 4534-1311 26.2 µM 0.0677433404473141 0.486404576259217 no 1614 0.472994973922895 2279 2862016
SGTC_2872 9044037 25.97 µM 0.0672535060439522 0.486625870944808 no 1615 0.47318994492102 2198 6465195
SGTC_968 1309-0633 340 µM 0.0668392322401613 0.486813032496533 no 1616 0.473354845207837 2289 3761976
SGTC_2183 6420625 130.508 µM 0.0666480683207721 0.486899397944274 no 1617 0.473430938900906 2282 2897619
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.0662226175832662 0.487091613420985 no 1618 0.473600295034602 2141 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2679 rapamycin 1 nM 0.0660411354709438 0.487173606603611 no 1619 0.473672537775289 2232 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2958 9077254 16.72 µM 0.0659715019635776 0.48720506699917 no 1620 0.47370025707549 2213 16457351
SGTC_3258 9138477 49.47 µM 0.0654428964117692 0.487443893394818 no 1621 0.473910685431177 2293 4970355
SGTC_391 gliotoxin 8.33 µM 0.0647876661215291 0.487739935664564 no 1622 0.474171530913707 2248 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_496 calpeptin 138 µM 0.0638505609136268 0.488163344689851 no 1623 0.474544609287043 2178 73364 A calpain inhibitor.
SGTC_2619 obliquin 87.91 µM 0.0629168025745203 0.488585254781379 no 1624 0.474916377416578 2260 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3232 9132874 49.47 µM 0.0617955916242551 0.489091880442614 no 1625 0.475362807077136 2267 3784940
SGTC_3106 9121286 49.47 µM 0.061457068501566 0.489244847572824 no 1626 0.475497602057355 2268 15943471
SGTC_3013 9080133 71.4286 µM 0.060468972403469 0.489691343689134 no 1627 0.475891063524485 2263 17050193
SGTC_808 0711-0032 135 µM 0.0602603934507179 0.489785597014094 no 1628 0.475974123019411 2295 4252555
SGTC_3210 9128157 49.47 µM 0.0598106396823539 0.489988835120995 no 1629 0.476153225754163 2084 17590849
SGTC_1148 3909-7663 27.7 µM 0.0592069503529282 0.490261638860681 no 1630 0.476393636887589 2300 4084526
SGTC_2875 9039966 71.43 µM 0.057602589061234 0.49098666230969 no 1631 0.477032593663406 2260 6463691
SGTC_2270 7924575 90.91 µM 0.0573538707873616 0.491099062774736 no 1632 0.477131654127928 2320 1262135
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.0569512305365273 0.491281024970003 no 1633 0.477292022218407 2263 368090
SGTC_1118 chelidonine 707.474 nM 0.0569096803368811 0.491299802544701 no 1634 0.477308571509301 2309 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1680 diphenhydramine 100 µM 0.0567165511914825 0.491387082689522 no 1635 0.477385494647065 2163 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_3141 9094609 49.47 µM 0.0561393876648468 0.491647920521897 no 1636 0.47761538328984 2220 25236309 YDL196W YDL196W
SGTC_2361 9034121 116 µM 0.0552169921879265 0.49206478658952 no 1637 0.477982795889525 2240 6496917
SGTC_3292 9120825 59.784 µM 0.054180631719087 0.492533168146228 no 1638 0.478395625832312 2319 24824900
SGTC_431 k089-0097 107 µM 0.0536962451450261 0.49275208950027 no 1639 0.478588587214026 2318 5499420
SGTC_2598 perillyl alcohol 100 µM 0.0529494761741802 0.493089600371758 no 1640 0.478886081685404 2263 10819 An apoptosis inducer.
SGTC_1826 st055655 41.6 µM 0.0528127639257083 0.493151389596164 no 1641 0.478940545776221 2189 676168
SGTC_2083 5306046 65.942 µM 0.0520044358643058 0.493516729328655 no 1642 0.479262579445057 2278 539837
SGTC_3118 9124250 49.47 µM 0.0516531929985828 0.493675482148623 no 1643 0.479402516995944 2212 1504786
SGTC_2416 tofa 880 nM 0.0513533972134321 0.493810982993188 no 1644 0.47952195968837 2095 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.0502149261102512 0.49432555228988 no 1645 0.479975558621811 2329 23665772 A membrane-active detergent.
SGTC_939 1165-0479 45.3 µM 0.0499265752182573 0.49445588345055 no 1646 0.480090449872733 2332 1377347
SGTC_2657 nystatin 74.44 µM 0.0494055039039827 0.494691402955191 no 1647 0.480298071019628 2286 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1720 st037298 9.481 µM 0.0489661015835294 0.49489001025732 no 1648 0.480473155268126 2273 597396
SGTC_1149 3909-7961 23.3 µM 0.0487301021000648 0.494996681181989 no 1649 0.480567193179389 2171 735261
SGTC_2377 9073351 62.6 µM 0.0487225528101483 0.495000093440047 no 1650 0.480570201337136 2282 7337946 YHR072W ERG7
SGTC_1027 k015-0025 8.67 µM 0.0485232414091716 0.495090181770835 no 1651 0.480649621144707 2335 3598955
SGTC_533 1222-0222 6.71 µM 0.0483453111352952 0.495170606089177 no 1652 0.480720521842801 2302 3982874
SGTC_2235 salicylic acid 500 µM 0.0481874966981083 0.495241938232398 no 1653 0.480783407400973 2322 338 A COX inhibitor and kinase inhibitor.
SGTC_2337 9009472 200 µM 0.0467597620953877 0.495887281068106 no 1654 0.481352349564136 2305 5742383
SGTC_1380 2291-0730 164 µM 0.0454319391260338 0.496487473064816 no 1655 0.481881511760744 2267 2999191
SGTC_1630 st005209 31.3 µM 0.04428067624714 0.497007864255151 no 1656 0.482340337342604 2332 3367314
SGTC_2148 5546263 113.568 µM 0.0440555867948108 0.497109609292862 no 1657 0.482430047494779 2292 792097
SGTC_2359 9039622 200 µM 0.0439609899433153 0.49715236906165 no 1658 0.482467749651298 2309 6463596
SGTC_1539 benzyladenosine 56 µM 0.0434102303662011 0.497401324621814 no 1659 0.482687261368554 2325 92208 A nucleotide analog.
SGTC_190 3970-0790 3.722 µM 0.0432247340441349 0.497485173311552 no 1660 0.482761194297599 2347 2832352
SGTC_3066 9117245 49.47 µM 0.0427448761905221 0.497702080826264 no 1661 0.482952453106684 2308 17176980
SGTC_343 4130-2827 29.8 µM 0.0425642896469981 0.497783710550837 no 1662 0.483024431205317 2275 1118244
SGTC_287 k060-0039 29.6 µM 0.0425149639472296 0.497806007041747 no 1663 0.483044091515569 2332 5861974
SGTC_2389 9091542 195.52 µM 0.0420934504469462 0.49799654230848 no 1664 0.483212100665619 2225 3626624 YOL127W RPL25
SGTC_354 2783-3500 4.88 µM 0.0415533057966837 0.498240702659252 no 1665 0.483427398819937 2293 6740761
SGTC_2333 9017922 200 µM 0.0410427873561274 0.498471471749513 no 1666 0.483630892602341 2327 3163164
SGTC_819 1013-0258 27.7 µM 0.040564406003954 0.498687714412643 no 1667 0.483821580340768 2301 5753198
SGTC_1216 1165-0504 9.65 µM 0.0404644716821111 0.498732887762518 no 1668 0.483861415660338 2322 6304004
SGTC_3192 9110362 49.47 µM 0.0403462355505715 0.498786334107394 no 1669 0.483908546563764 2344 16649480
SGTC_653 0203-0016 55.2 µM 0.0403097270375714 0.498802837075454 no 1670 0.483923099514313 2300 295302
SGTC_1449 4112-4002 201 µM 0.0402320941293643 0.498837929538736 no 1671 0.483954045460328 2187 2059539
SGTC_1213 1315-0166 115 µM 0.0397151025504102 0.499071625856562 no 1672 0.484160130541203 2192 768401
SGTC_31 0508-1974 57.237 µM 0.0395019435216296 0.499167980482987 no 1673 0.484245102010812 2327 6810525
SGTC_2693 st077581 40.7 µM 0.0390937692373946 0.499352488306803 no 1674 0.484407814300872 2351 25238761
SGTC_1116 jasmonic acid 1.58368 µM 0.0381382573346515 0.499784410702528 no 1675 0.484788724272115 2329 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_445 e6 berbamine 66 µM 0.038031380904223 0.499832722343298 no 1676 0.484831330888307 2298 6610268 A calcium/calmodulin antagonist.
SGTC_134 0269-0018 6.916 µM 0.037813486199574 0.499931217880486 no 1677 0.484918195815332 2284 4378915
SGTC_1235 benzylparaben 21.5 µM 0.0377683896252317 0.499951603008613 no 1678 0.484936173903204 2306 7180
SGTC_1659 st012954 42.1 µM 0.037554259158355 0.499951603008613 no 1679 0.485021539038426 2318 24207262
SGTC_1064 honokiol 6.76 µM 0.0372615485469513 0.499819288233128 no 1680 0.485138232001028 2265 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1730 st033808 45.1 µM 0.0371307133265665 0.499760146437413 no 1681 0.485190391606917 2155 1045166
SGTC_225 nsc-122657 1.016 µM 0.0366973185416765 0.499564237874765 no 1682 0.485363173349201 2325 275685
SGTC_1096 rimcazole 32.2 µM 0.0364743111084413 0.499463431287393 no 1683 0.485452080920699 2334 18528119 A dopamine reuptake inhibitor.
SGTC_3352 9151559 45.5865 µM 0.0363495734370279 0.499407045831763 no 1684 0.48550181107397 2308 17159339
SGTC_787 4152-0075 138 µM 0.0357299240077315 0.499126944477044 no 1685 0.485748854936158 2231 9566539
SGTC_147 4466-0538 29.23 µM 0.0355461962937069 0.499043893752293 no 1686 0.485822105157985 2248 6742687 YHR072W ERG7
SGTC_639 0833-0042 114 µM 0.0340613255479999 0.498372687148711 no 1687 0.486414124159588 2306 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1658 st012944 20 µM 0.0334070960531523 0.498076956927962 no 1688 0.486674975495269 2327 24207260
SGTC_1039 k821-0043 94 µM 0.0328335749737252 0.497817710055605 no 1689 0.486903651841003 2326 15992768
SGTC_605 1315-0399 119 µM 0.0325647142549399 0.497696178127993 no 1690 0.487010854421295 2321 24020461
SGTC_2791 5663188 71.43 µM 0.0322820210687999 0.497568393801828 no 1691 0.487123573420358 2347 54690634
SGTC_2149 5554786 194.827 µM 0.0318521715908006 0.497374091667188 no 1692 0.487294970403718 2321 745063 YPR165W RHO1
SGTC_1686 st019653 115.5 µM 0.0315148527024078 0.497221615982292 no 1693 0.487429473642496 2358 97252
SGTC_3347 9188721 44.724 µM 0.0310900805034415 0.497029610024378 no 1694 0.487598850229248 2306 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1285 0929-0069 65.5 µM 0.0300429816519374 0.496556302376586 no 1695 0.488016387113207 2330 1206237
SGTC_2755 lomerizine 42.69 µM 0.0298830897277278 0.496484028740651 no 1696 0.488080146134677 2338 3949 A calcium channel blocker.
SGTC_3127 9126946 49.47 µM 0.028917833087848 0.49604772026623 no 1697 0.488465061410967 2268 27243249
SGTC_1801 st050089 28.441 µM 0.0284020539423818 0.495814583332289 no 1698 0.48867074302716 2345 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2110 5483698 200 µM 0.0283332162435109 0.495783468163469 no 1699 0.488698194248187 2326 2848765 YHR062C RPP1
SGTC_2260 7964312 200 µM 0.0282137583377706 0.495729472333184 no 1700 0.488745832013103 2349 231951
SGTC_2126 5251174 33.877 µM 0.0279885223388012 0.495627664259617 no 1701 0.488835652704432 2345 790722
SGTC_1527 coumarin 137 µM 0.0271008487201673 0.49522643309443 no 1702 0.489189648914829 2321 323 A hepatotoxic, DNA x-linker.
SGTC_527 4476-4215 268 µM 0.0261203073742805 0.494783231064719 no 1703 0.489580689822708 2227 4418754
SGTC_2312 7706453 155.7 µM 0.0257115652294566 0.494598482593665 no 1704 0.489743699594138 2344 976098
SGTC_961 1252-1571 372 µM 0.025576514361031 0.494537440837906 no 1705 0.489797559383055 2357 6813498
SGTC_510 ag-490 170 µM 0.0255198641641402 0.4945118355057 no 1706 0.489820152167314 2349 5328779
SGTC_2571 chrysanthemic acid 100 µM 0.0255089610106412 0.494506907390071 no 1707 0.48982450048066 2303 2743 An insecticide.
SGTC_2568 diosmetin 100 µM 0.0252345156788961 0.494382861140871 no 1708 0.489933953092441 2365 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1367 1812-0510 76.9 µM 0.0249070853453569 0.494234866969484 no 1709 0.490064537850142 2345 1142582 YDR527W RBA50
SGTC_3312 9133330 71.43 µM 0.0244603049289041 0.494032929426372 no 1710 0.49024272315577 2344 17617324
SGTC_1385 3091-4834 14.1 µM 0.0236489536734019 0.493666215689132 no 1711 0.490566311835149 2336 4072814
SGTC_3277 9138724 49.47 µM 0.0235440936051348 0.493618821523315 no 1712 0.490608133305255 2266 15943418
SGTC_1236 0330-0013 258 µM 0.0234318146049028 0.49356807428302 no 1713 0.490652913791583 2343 4617066
SGTC_1273 0849-0096 14.1 µM 0.022765285998259 0.493266822548084 no 1714 0.490918749302149 2337 5286025
SGTC_2256 7954252 200 µM 0.0221045483059315 0.4929681919293 no 1715 0.491182279170082 2270 2972920
SGTC_1318 1280-3875 124 µM 0.0220162205032781 0.492928271107809 no 1716 0.491217508291729 2344 373245
SGTC_1348 1493-0373 93.8 µM 0.0217659289178178 0.492815149176705 no 1717 0.491317336264733 2341 3010129
SGTC_3095 9117207 49.47 µM 0.0214486515870636 0.49267175316067 no 1718 0.491443882062071 2372 17015229
SGTC_2094 5332512 191.667 µM 0.0211372692582882 0.492531022358377 no 1719 0.491568077480206 2362 755774
SGTC_1324 1418-0026 34.4 µM 0.0208962368077108 0.492422087173131 no 1720 0.491664214281112 2296 1372513
SGTC_76 0433-0009 400.328 µM 0.0197127940191808 0.491887235763221 no 1721 0.492136242306037 2256 2841569
SGTC_2955 9076254 12.21 µM 0.0190233759487125 0.49157566316602 no 1722 0.492411228736109 2368 16459619
SGTC_296 1222-0039 74.9 µM 0.0189623848322164 0.491548099351418 no 1723 0.492435556282977 2365 5984176
SGTC_105 0111-0055 734.78 µM 0.0186282943334823 0.491397114007768 no 1724 0.492568815567797 2322 5179370
SGTC_3181 9108277 49.47 µM 0.017907285803474 0.49107127323037 no 1725 0.492856408358111 2370 17097298
SGTC_1649 st011737 51.3 µM 0.0173747517303152 0.490830612323202 no 1726 0.493068825657847 2354 1761035
SGTC_2463 5473429 200 µM 0.0173638892857689 0.490825703440278 no 1727 0.493073158492602 2294 5399405
SGTC_50 0929-0078 56.389 µM 0.0170945844630875 0.490704001461185 no 1728 0.493180579627378 2318 1377751
SGTC_1117 retinoic acid 1.10837 µM 0.0169711834205973 0.490648235384426 no 1729 0.493229802379893 2366 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_1171 0368-0077 21.4 µM 0.0165763228687575 0.490469795468803 no 1730 0.493387306788677 2366 3239779
SGTC_733 4069-0007 56.1 µM 0.0162693660288046 0.4903310810979 no 1731 0.493509748336955 2370 5717425 YNL287W SEC21
SGTC_2119 5528445 120.635 µM 0.0145570152623685 0.489557288506362 no 1732 0.494192796233675 2367 791935
SGTC_132 0417-1715 25.805 µM 0.0139513004695607 0.489283581873335 no 1733 0.494434416923081 2378 6769098
SGTC_1531 st059297 52.4 µM 0.0135239042986685 0.489090455779203 no 1734 0.494604907236463 2381 7566702
SGTC_1987 st072290 61.9 µM 0.0111659930252836 0.488025041417843 no 1735 0.495545505843683 2368 54697379
SGTC_854 0422-0053 192 µM 0.0109352850881429 0.487920801271045 no 1736 0.495637539374444 2384 3596728
SGTC_802 4112-3352 742 µM 0.00903516412927718 0.487062306766215 no 1737 0.496395540059727 2373 704594
SGTC_1744 st037937 38.9 µM 0.00680768953952651 0.486055987092322 no 1738 0.497284145788399 2385 1016152
SGTC_2682 pyrogallin 40.03 µM 0.00666502476779415 0.485991537522522 no 1739 0.497341059506374 2395 822798 An ATP competetive kinase inhibitor.
SGTC_2947 9072639 7.68 µM 0.00650728278844698 0.48592027716997 no 1740 0.49740398808641 2391 16488146
SGTC_603 3794-0023 45.9 µM 0.00638891598626176 0.48586680495203 no 1741 0.497451208626692 2389 3802260
SGTC_3185 9108267 49.47 µM 0.00568782687031822 0.485550093097178 no 1742 0.497730897612597 2391 4910486
SGTC_2980 9014342 25.29 µM 0.00458253190388032 0.485050802810319 no 1743 0.498171840670691 2373 2996599
SGTC_750 4073-0104 132 µM 0.00440358466432545 0.484969969903662 no 1744 0.498243229569828 2393 22330957
SGTC_1970 st070122 35.8 µM 0.00440200264100105 0.484969255284918 no 1745 0.498243860699703 2396 102928
SGTC_584 0986-0246 15.4 µM 0.00374007494967823 0.484670258940542 no 1746 0.498507929449258 2395 53315 YDR232W HEM1
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.0027994404953629 0.484245384100226 no 1747 0.498883186283652 2400 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_3114 9122766 49.47 µM 0.00163820666088751 0.483720891528286 no 1748 0.499346450391261 2397 17176985
SGTC_344 k064-0035 6.43 µM 0.000346971903818329 0.483137714767702 no 1749 0.499861578240233 2404 5088750
SGTC_2436 5633522 8.09 µM 0 0.482981013535239 no 1750 0.5 2406 5724242
SGTC_3325 9138760 55.175 µM 0 0.482981013535239 no 1751 0.5 2405 43844959
SGTC_2816 7982706 58.44 µM -0.000446853403677616 0.482779207183482 no 1752 0.499821731290064 2409 2981853
SGTC_2251 lansoprazole 556 µM -0.00109711012640532 0.482485548440552 no 1753 0.499562316472123 2407 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1242 0402-0103 60.1 µM -0.00226971872037451 0.481956017462197 no 1754 0.499094514015278 2412 432868
SGTC_983 1491-0821 12.2 µM -0.00253408355553079 0.481836638964273 no 1755 0.498989048009614 2413 46495113
SGTC_2385 9074692 200 µM -0.00260046355936627 0.481806664184801 no 1756 0.498962566306785 2409 17046906
SGTC_471 1-acyl-paf 4 µM -0.00284326182680223 0.481697026253774 no 1757 0.498865704171338 2414 16759367
SGTC_2804 7954240 19.48 µM -0.00328582633386451 0.481497185491618 no 1758 0.498689147308169 2414 828705
SGTC_2284 7945075 39.21 µM -0.00410432011126896 0.481127605510988 no 1759 0.498362617772386 2417 1245402
SGTC_141 0443-0274 32.331 µM -0.00432423741796591 0.481028307527022 no 1760 0.498274884239813 2411 1627241
SGTC_2219 9098279 200 µM -0.0045679963718036 0.480918245838327 no 1761 0.498177639448311 2414 902349
SGTC_2802 7925815 54.55 µM -0.0048364056618702 0.48079705574858 no 1762 0.498070560818171 2415 1262923
SGTC_2515 chrysin 20.77 µM -0.00505885785500917 0.480696617196815 no 1763 0.49798181631934 2416 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1140 3229-1848 2.98 µM -0.00540320491350894 0.48054114477248 no 1764 0.497844443598776 2404 2849525
SGTC_2822 7994718 71.43 µM -0.006715127379952 0.479948840140722 no 1765 0.497321071903326 2419 1018011
SGTC_476 mead acid 10 µM -0.00732453153770995 0.479673722316738 no 1766 0.497077960812795 2418 5312531 An omega 9 fatty acid.
SGTC_2699 st077704 54.6 µM -0.0076113031474531 0.479544261525652 no 1767 0.496963558683377 2434 645852
SGTC_2878 9043973 25.97 µM -0.007718553092669 0.479495844933852 no 1768 0.49692077340254 2442 6465167
SGTC_1342 1486-1464 234 µM -0.00881196798779151 0.479002254400654 no 1769 0.49648457889205 2419 3253938
SGTC_1388 3346-4487 254 µM -0.00930049855184539 0.478781731768071 no 1770 0.496289691388767 2438 3345614
SGTC_1821 st053465 65.6 µM -0.0118189706795219 0.477644998313183 no 1771 0.495285022656382 2436 675086
SGTC_822 1487-0950 154 µM -0.0122246080196168 0.477461927270004 no 1772 0.49512320846541 2423 1958375
SGTC_1305 1181-0477 144 µM -0.0131609595032829 0.477039354115925 no 1773 0.494749688372421 2439 6252086
SGTC_2628 lathosterol 100 µM -0.0134633123983659 0.476902908478787 no 1774 0.494629077706791 2457 6710616
SGTC_402 epigallocatechin gallate 10 µM -0.0135266388128184 0.476874330914049 no 1775 0.494603816422929 2435 65064 An antioxidant.
SGTC_316 k060-0003 58.6 µM -0.0135449625152362 0.476866061925632 no 1776 0.494596506992942 2434 6152314
SGTC_717 1532-0246 73.2 µM -0.0138590201433159 0.476724337813237 no 1777 0.49447122788792 2441 9561992
SGTC_2399 5884133 200 µM -0.014039940292261 0.476642695700925 no 1778 0.494399058213246 2442 722445
SGTC_2840 9008771 71.43 µM -0.0143013545953692 0.476524731491075 no 1779 0.494294779465821 2450 2992978
SGTC_1575 cyproterone acetate 48 µM -0.0151693209971096 0.476133073125808 no 1780 0.493948548571695 2450 9880 An androgen receptor antagonist and liver toxin.
SGTC_145 3737-0113 38.366 µM -0.0153730621686918 0.476041140942755 no 1781 0.493867277081419 2444 6849351
SGTC_191 3914-0123 66.505 µM -0.0178545419739788 0.474921550327588 no 1782 0.492877446738186 2444 3144412
SGTC_3044 9093193 49.47 µM -0.0181456047084679 0.474790241851197 no 1783 0.492761348317179 2460 25236277
SGTC_1942 st076330 65.2 µM -0.0188636374481977 0.474466324163058 no 1784 0.492474943744409 2486 24208414
SGTC_526 4469-0568 170 µM -0.0194491899619058 0.474202183210084 no 1785 0.492241384950886 2434 2901964
SGTC_609 0986-0026 86.3 µM -0.0205134827958477 0.473722113077892 no 1786 0.491816878312134 2436 2848610
SGTC_2395 5646831 180.19 µM -0.0209393603701439 0.473530023306001 no 1787 0.491647014232167 2455 6808628
SGTC_407 eburnamonine 100 µM -0.0213959404272123 0.473324092183048 no 1788 0.491464905947743 2444 3195
SGTC_1054 3429-0080 167 µM -0.0228001824454315 0.472690782377037 no 1789 0.49090483124651 2453 1162877
SGTC_2461 5755302 26.15 µM -0.024104741275388 0.472102491270579 no 1790 0.490384530715851 2443 2788904
SGTC_2967 9089538 49.85 µM -0.0247912784565058 0.471792921528706 no 1791 0.490110723852731 2451 728216
SGTC_916 4466-0038 42 nM -0.0248806094293816 0.471752642124257 no 1792 0.490075096940177 2447 5722064 YGL116W CDC20
SGTC_2570 licareol 100 µM -0.0250203634265613 0.471689627519046 no 1793 0.490019360513301 2494 443158
SGTC_2786 7743617 45.45 µM -0.0251596253557141 0.471626835490607 no 1794 0.489963820525937 2472 583674
SGTC_1523 st012844 44.7 µM -0.0254418212209486 0.471499597920991 no 1795 0.48985127669123 2527 4274103
SGTC_1429 4049-0205 9.46 µM -0.0254867776112348 0.471479328077121 no 1796 0.489833347500232 2449 22774478
SGTC_3327 9140648 26.9345 µM -0.0255662597434976 0.471443491519229 no 1797 0.489801649046233 2454 8029710
SGTC_444 curcumin 90.4 µM -0.0268637476493212 0.47085851872257 no 1798 0.489284204130033 2467 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1386 3228-0095 33.8 µM -0.0268680112666442 0.470856596572422 no 1799 0.489282503806552 2463 870181
SGTC_697 0508-1955 564 µM -0.0269227789578357 0.470831905925905 no 1800 0.489260662559934 2448 6243113
SGTC_3201 9113999 49.47 µM -0.0274224985766174 0.470606625000038 no 1801 0.489061376862837 2505 16649224
SGTC_477 mead ethanolamide 10 µM -0.0279889356219242 0.470351278258929 no 1802 0.488835487892887 2452 16061185
SGTC_3240 9133527 49.47 µM -0.0280426762138061 0.470327052923741 no 1803 0.488814056910697 2453 17617455
SGTC_3082 9117008 49.47 µM -0.028618512928607 0.470067482540494 no 1804 0.488584423474712 2481 41448529
SGTC_123 0083-0120 66.675 µM -0.0306278526706491 0.469161831171424 no 1805 0.487783164673297 2471 16001701
SGTC_1893 st059353 36.1 µM -0.0307106159052246 0.469124531442672 no 1806 0.487750162444402 2499 3112488
SGTC_1513 0337-0559 19 µM -0.0318809308563002 0.468597123143328 no 1807 0.487283502940709 2486 775073
SGTC_602 3130-1533 38.1 µM -0.0322354706966724 0.468437358820344 no 1808 0.487142134671787 2501 720941
SGTC_1994 st072947 40.9 µM -0.0331162575721474 0.468040476767111 no 1809 0.48679093909642 2550 5286565 YDL195W SEC31
SGTC_1520 flindersine 88 µM -0.0332428894582861 0.467983419115365 no 1810 0.486740448083053 2513 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1143 3454-2408 5.08 µM -0.0342471952116027 0.467530923556182 no 1811 0.486340016128857 2451 X1143
SGTC_2983 9022671 12.99 µM -0.0344915295080301 0.467420843698653 no 1812 0.486242598402191 2499 6405161
SGTC_754 3474-0146 171 µM -0.0360995832837459 0.466696430258328 no 1813 0.485601477302069 2468 24762078
SGTC_2329 6138490 200 µM -0.0361356473231929 0.466680184995901 no 1814 0.485587099212971 2629 720019
SGTC_179 1273-0063 6.77 µM -0.0370977509943007 0.466246820216777 no 1815 0.485203532621149 2480 3108139
SGTC_1862 st057513 3.81 µM -0.0390294607545393 0.465376832659247 no 1816 0.484433450108522 2482 5393163
SGTC_1806 st050005 60.3 µM -0.0394761727196557 0.465175669601569 no 1817 0.484255375060372 2488 5194765
SGTC_2018 5133068 143 µM -0.0412423845296818 0.464380397829105 no 1818 0.483551332215822 2478 785362
SGTC_2874 9043904 71.43 µM -0.0420950870337254 0.463996502406077 no 1819 0.48321144834015 2546 4463428
SGTC_40 0327-0103 19.753 µM -0.042430320597016 0.463845585972889 no 1820 0.483077828883141 2504 409036
SGTC_491 tetrandrine 80.3 µM -0.0429596998842533 0.463607279047875 no 1821 0.482866829504795 2497 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2727 riluzole 51.77 µM -0.0429598860157282 0.463607195260679 no 1822 0.48286675531757 2486 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1713 st033146 12.748 µM -0.0431733953054819 0.463511084987899 no 1823 0.482781656389397 2492 674619
SGTC_2519 cryptotanshinone 88.04 µM -0.0435080319792768 0.463360454039745 no 1824 0.482648280998445 2491 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_780 0109-0199 192 µM -0.0436122491891963 0.463313543525301 no 1825 0.48260674377393 2482 610414
SGTC_11 0438-0307 1.3 µM -0.0450943728799389 0.462646461779603 no 1826 0.482016043326506 2508 4011476
SGTC_2908 7930301 100 µM -0.045195699040343 0.462600860202374 no 1827 0.481975661208879 2483 2223178
SGTC_1057 3448-5381 134 µM -0.0455558828177836 0.462438764405205 no 1828 0.481832116524765 2523 5497911
SGTC_1751 st044839 27.194 µM -0.0458273086412831 0.462316617034725 no 1829 0.481723946261779 2481 5291326
SGTC_2481 5478948 45.16 µM -0.0462859495048977 0.462110227011875 no 1830 0.481541168988972 2552 77792
SGTC_2166 5933061 31.504 µM -0.0471630528013813 0.461715555860229 no 1831 0.48119163716451 2634 2877375
SGTC_2591 skatole 100 µM -0.0478219167395977 0.461419110890031 no 1832 0.480929084752518 2528 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2698 st077697 67.5 µM -0.0493642327038223 0.460725255344001 no 1833 0.480314515780823 2525 3154499
SGTC_1150 3909-7983 10.9 µM -0.0505213897956401 0.46020475306659 no 1834 0.47985345228797 2503 23965914
SGTC_1254 0550-0035 264 µM -0.0524651838016844 0.459330566576345 no 1835 0.479079018205904 2547 15121435
SGTC_1560 lithocholic acid 53.1 µM -0.0537082583374188 0.458771618899775 no 1836 0.478583801549401 2507 9903 A bile acid which acts as a detergent.
SGTC_3140 9094243 49.47 µM -0.0537390533137397 0.458757772988196 no 1837 0.478571533847815 2503 19291112
SGTC_2248 tofa 1.1 µM -0.0540445618632342 0.458620414194046 no 1838 0.478449830432508 2500 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_571 k831-0106 44.2 µM -0.0546191859363918 0.458362072565054 no 1839 0.47822092670346 2516 4783639
SGTC_1818 st052136 56.3 µM -0.0548091673151137 0.45827666389308 no 1840 0.478145248460682 2525 674169
SGTC_2243 6634756 200 µM -0.0549611842290365 0.458208324041655 no 1841 0.47808469376212 2575 885676
SGTC_838 0109-0203 71.4 µM -0.0559200533155887 0.457777288911329 no 1842 0.477702747794459 2505 759422
SGTC_2700 st077718 96.8 µM -0.0563528815551345 0.457582738256131 no 1843 0.477530346169893 2553 904970
SGTC_3285 9112818 20.8695 µM -0.0567743749610317 0.457393292228508 no 1844 0.477362463411287 2492 17017947 YPR165W RHO1
SGTC_1627 st003713 25.6 µM -0.0569645905794516 0.457307800361697 no 1845 0.477286700971026 2554 16195070 YER133W GLC7
SGTC_1420 4'-methoxyflavone 42 µM -0.0569830508090548 0.457299503569293 no 1846 0.477279348347988 2498 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3137 9097352 49.47 µM -0.0573780891193432 0.457121961443594 no 1847 0.477122008295925 2570 44120435
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.059705878889888 0.456075957493664 no 1848 0.476194944706822 2502 15053
SGTC_1249 0481-0015 10.2 µM -0.0597625367642275 0.456050501759766 no 1849 0.476172381775413 2511 4227577
SGTC_1915 st067105 30.6 µM -0.0600937692370491 0.455901686417614 no 1850 0.47604047621249 2503 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_198 3454-2873 16.191 µM -0.0604080812913291 0.455760478761111 no 1851 0.475915311236937 2530 710957
SGTC_2373 9071805 200 µM -0.0610343949749151 0.455479118107526 no 1852 0.475665908438536 2522 10149009
SGTC_1354 1498-1681 81 µM -0.0613123151455377 0.455354274393347 no 1853 0.475555241593688 2574 5754243
SGTC_672 1441-0018 53.7 µM -0.0615676611557535 0.455239575038198 no 1854 0.475453565362962 2525 251141
SGTC_507 nimesulide 162 µM -0.0616849311239218 0.455186899570065 no 1855 0.47540687016822 2547 4495 A COX2 inhibitor.
SGTC_2624 nerol 100 µM -0.0619579393796688 0.455064272440658 no 1856 0.475298163563385 2510 637566 A natural product oil.
SGTC_702 1488-0190 94 µM -0.0621873534564627 0.454961229820658 no 1857 0.475206816738527 2518 949357
SGTC_2664 lyso-paf C-16 73.48 µM -0.0622442619364413 0.454935669526344 no 1858 0.475184157437107 2514 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1360 1598-0022 39.8 µM -0.063463715793386 0.454388000034847 no 1859 0.47469862578893 2587 761525
SGTC_2676 harmalol 100 µM -0.0635117922372774 0.454366410170367 no 1860 0.47467948467766 2512 5459187 A monoamine oxidase inhibitor
SGTC_1009 4106-0057 9.87 µM -0.063686510617976 0.454287949883958 no 1861 0.474609922954322 2502 2928005
SGTC_2045 5106652 78.05 µM -0.0637966816840955 0.454238476593344 no 1862 0.47456606025544 2550 673349
SGTC_2688 kanamycin b 96.69 µM -0.0639447166634946 0.454172001295986 no 1863 0.474507123181821 2550 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2297 7971671 152.32 µM -0.064341430014867 0.453993862991415 no 1864 0.474349182698159 2558 909016
SGTC_923 1900-2434 73.3 µM -0.0654859655654522 0.453479978100153 no 1865 0.473893540103121 2509 5910570
SGTC_2928 9011484 9.79 µM -0.065490041715479 0.453478148088673 no 1866 0.473891917437812 2590 2994751
SGTC_1396 3511-0007 98.6 µM -0.0660230509597101 0.453238858984594 no 1867 0.473679736739723 2585 X1396
SGTC_2488 5268135 45.7 µM -0.066042281216859 0.453230226072128 no 1868 0.473672081684508 2582 1270356 YLR208W SEC13
SGTC_1578 josamycin 24.2 µM -0.0666859423315106 0.452941284311178 no 1869 0.47341586289652 2530 5282165 A P450 substrate.
SGTC_766 1391-0721 126 µM -0.067757952276266 0.45246011061493 no 1870 0.472989158009818 2546 1020919 YIL115C NUP159
SGTC_1870 st057514 26.5 µM -0.067805481672088 0.452438778566492 no 1871 0.472970240032229 2511 5393161
SGTC_1466 k213-0079 57.5 µM -0.0685463064491344 0.452106300855488 no 1872 0.47267537975817 2521 3657981
SGTC_736 0958-0254 92.6 µM -0.0692668808275865 0.451782943619195 no 1873 0.472388593834243 2591 6812352
SGTC_1485 3909-9022 254 µM -0.0705176497492071 0.45122173803078 no 1874 0.471890826525639 2525 714516
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0705619669022121 0.451201855217021 no 1875 0.471873190471495 2588 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2402 5553605 200 µM -0.0719964030306387 0.450558364330806 no 1876 0.471302385195053 2602 6758546
SGTC_1760 st045453 10.4495 µM -0.0729267769430024 0.450141066117976 no 1877 0.470932192876099 2530 3323419 YIL048W NEO1
SGTC_2522 biochanin a 4.94 µM -0.0732952427744596 0.449975814300338 no 1878 0.470785588617916 2576 5280373 A possible chelator.
SGTC_2806 7952793 58.44 µM -0.0742511747957341 0.449547132551779 no 1879 0.470405263299021 2620 2972490
SGTC_107 0358-0022 2.6945 µM -0.0748421552211524 0.44928214048706 no 1880 0.470170150417566 2620 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1180 1193-0155 285 µM -0.0749002282541746 0.44925610210733 no 1881 0.47014704747421 2606 2921347
SGTC_2629 bisabolol 100 µM -0.0756943482229113 0.448900062130852 no 1882 0.469831136279775 2602 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2040 5100729 123 µM -0.0757211041024458 0.448888066972224 no 1883 0.469820492774405 2538 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2489 cantharidin 73.42 µM -0.0759556459941712 0.448782919479125 no 1884 0.469727192789167 2563 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1427 4048-4900 550 nM -0.0763080866174679 0.448624923563298 no 1885 0.469586996207196 2604 24132586
SGTC_363 0455-0021 3.06 µM -0.0767632158482764 0.448420905339479 no 1886 0.469405956930212 2556 4597466
SGTC_770 0389-1121 67.2 µM -0.0768386283450346 0.44838710191904 no 1887 0.469375960293178 2722 6753108
SGTC_1204 4049-0315 18.3 µM -0.0768754978170763 0.448370575427624 no 1888 0.469361294880309 2789 588402
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.077436767415121 0.448119001208187 no 1889 0.469138046207169 2594 23847180
SGTC_2412 st077135 33.4 µM -0.0776787934066908 0.448010525905441 no 1890 0.469041781767612 2827 13258915
SGTC_1460 k062-0059 9.15 µM -0.0790801620555732 0.447382513475257 no 1891 0.468484431238255 2492 1373085
SGTC_1843 st055809 45.5 µM -0.0823860092276218 0.445901549194378 no 1892 0.467169880623066 2667 16413835
SGTC_1478 0453-0656 35.7 µM -0.0841754719304604 0.445100213203711 no 1893 0.466458459763324 2569 5258496
SGTC_1926 methyl fluorone black 53.6 µM -0.0844621236200139 0.444971868995901 no 1894 0.466344508084675 2544 72721 Reacts with homocysteine.
SGTC_1778 st046819 58.9 µM -0.0854289920066538 0.444539010076029 no 1895 0.465960172559098 2563 671715
SGTC_2470 5664817 21.68 µM -0.0859321775722955 0.44431376422408 no 1896 0.46576016605333 2546 2859561
SGTC_2496 diffractaic acid 79.83 µM -0.0872391036819811 0.443728816362856 no 1897 0.46524072879123 2578 94870 An apoptosis inducer which activates caspases.
SGTC_573 3702-0553 84.7 µM -0.0876997690515838 0.443522663069096 no 1898 0.465057651593959 2565 1222756
SGTC_1722 st034304 3.6505 µM -0.087922030343397 0.443423203930383 no 1899 0.464969323363469 2583 4036148 YLR033W RSC58
SGTC_1642 st009582 77.7 µM -0.0881995962471312 0.443299001677358 no 1900 0.464859019108029 2597 6739311
SGTC_862 0452-0056 10.2 µM -0.0887242748358046 0.443064239282297 no 1901 0.464650520042061 2562 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_79 0052-0007 94.094 µM -0.0927286798208046 0.441273170991533 no 1902 0.463059555983296 2592 2801472
SGTC_999 SEC7.066 22.7 µM -0.0927597715669453 0.441259269094993 no 1903 0.463047205402282 2589 740511 YDR170C SEC7
SGTC_3075 9116269 49.47 µM -0.0928401491480426 0.441223330605652 no 1904 0.463015277163534 2680 17015205 YNL244C SUI1
SGTC_447 ml7 120 µM -0.0931286105960595 0.441094357476018 no 1905 0.462900694116251 2603 4216 Selective myosin light chain kinase inhibitor.
SGTC_2213 7173844 200 µM -0.0931734024923882 0.441074331266076 no 1906 0.462882902094346 2573 892728
SGTC_199 4063-0024 41.6 µM -0.0937231487387585 0.44082855503818 no 1907 0.462664540590098 2673 306215
SGTC_2185 6113692 200 µM -0.0950929015173252 0.440216276074804 no 1908 0.462120518147572 2665 874150
SGTC_3241 9133421 49.47 µM -0.0953959986899227 0.440080811017346 no 1909 0.462000147084253 2555 17018221
SGTC_2751 anetholtrithion 17.25 µM -0.0955329391774597 0.44001960967415 no 1910 0.461945764108046 2667 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1605 st000082 49.1 µM -0.0955958036442347 0.439991514812212 no 1911 0.461920799072194 2700 1114022
SGTC_292 k038-0015 474 µM -0.095764079785658 0.439916311733233 no 1912 0.461853973189635 2664 46368540
SGTC_3134 9127454 49.47 µM -0.095910644631229 0.43985081325936 no 1913 0.461795770182155 2551 24262820
SGTC_46 0329-0187a 2.197 µM -0.0966563753288317 0.439517578642438 no 1914 0.461499642498045 2628 46494817
SGTC_217 ketoconazole 989 nM -0.0974300732126205 0.439171892000669 no 1915 0.461192431680269 2581 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1827 berberine 7.24 µM -0.0975192779843254 0.439132038467366 no 1916 0.461157012788524 2589 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_262 fenpropimorph 62.5 µM -0.0976925052171427 0.439054648436419 no 1917 0.461088233529787 2574 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.0984472791905217 0.438717477058665 no 1918 0.460788566810072 2675 6708760
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.0984603662479715 0.438711631221565 no 1919 0.460783371072197 2576 688803
SGTC_3145 9085516 49.47 µM -0.0986905087349224 0.438608831422248 no 1920 0.46069200250352 2654 25236195
SGTC_1462 k081-0014 26.5 µM -0.0999348520081933 0.438053081409543 no 1921 0.460198023468502 2566 3270634
SGTC_2762 leflunomide 42.06 µM -0.100702347595309 0.437710362491458 no 1922 0.459893373869168 2599 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2096 5468907 200 µM -0.101010327437067 0.43757284971757 no 1923 0.459771131000278 2683 759785
SGTC_2224 6650123 117.647 µM -0.102171810646947 0.437054316285957 no 1924 0.459310151241389 2576 2908370
SGTC_2310 7668677 200 µM -0.102844399964238 0.436754094382032 no 1925 0.459043232997515 2699 2197143
SGTC_260 nsc-65238 3.989 µM -0.103055642459968 0.436659810139512 no 1926 0.458959404848855 2594 3246252
SGTC_2249 haloperidol 116.36 µM -0.104504633122332 0.436013176800336 no 1927 0.45838444585693 2584 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1241 0364-0022 50.8 µM -0.104611587867884 0.435965453432025 no 1928 0.458342009686561 2672 4563895
SGTC_3276 9139060 49.47 µM -0.107037358230321 0.434883322739284 no 1929 0.457379671202833 2583 4870619
SGTC_2922 7999257 32.47 µM -0.107664907139645 0.434603453643981 no 1930 0.457130753849052 2593 2988377
SGTC_2376 9072922 81.32 µM -0.108695183450145 0.434144050619428 no 1931 0.45672213113538 2729 17087968
SGTC_557 1315-0110 16.2 µM -0.108877283938201 0.434062860744418 no 1932 0.456649912154097 2609 6833801
SGTC_1010 4112-3296 15.2 µM -0.108983484225963 0.434015512412809 no 1933 0.456607794989386 2614 704384
SGTC_3284 9108171 64.8615 µM -0.109336117298508 0.43385830129362 no 1934 0.45646795041927 2689 8687505
SGTC_909 3448-9333 149 µM -0.110259049575016 0.433446888577165 no 1935 0.456101966448897 2603 3344074
SGTC_1741 st038134 10.228 µM -0.111250138545582 0.433005174157582 no 1936 0.455708996774232 2731 1272587
SGTC_752 1896-0090 130 µM -0.112005673883777 0.432668498867279 no 1937 0.455409453886886 2603 772567
SGTC_2013 4024628 200 µM -0.112382640785781 0.432500536314321 no 1938 0.455260009386807 2719 5230760
SGTC_1690 st023502 41.2 µM -0.112688123359968 0.432364433487481 no 1939 0.455138908727661 2632 24207482
SGTC_2453 5731132 22.18 µM -0.112802750336251 0.432313365359438 no 1940 0.455093468905023 2697 1362040
SGTC_2716 st080858 38.6235 µM -0.113308077064492 0.432088247814262 no 1941 0.454893156955365 2647 5296050
SGTC_1756 st041558 35.5 µM -0.113366830305142 0.432062075315841 no 1942 0.454869867863539 2687 3955792
SGTC_2856 9022925 19.48 µM -0.117448093261184 0.430244752483431 no 1943 0.453252487421381 2736 4944862
SGTC_3216 9129716 49.47 µM -0.117576175457638 0.430187743173534 no 1944 0.453201741607324 2656 8056934
SGTC_195 4234-0266 16.654 µM -0.117732179425572 0.430118307865506 no 1945 0.453139934296508 2640 2303354
SGTC_411 enrofloxacin 100 µM -0.118476123538983 0.429787217916265 no 1946 0.452845206247206 2736 71188 A bacterial gyrase inhibitor.
SGTC_1100 amiodarone 5.07 µM -0.118560396458403 0.429749715631821 no 1947 0.452811821512514 2626 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2072 5231554 129 µM -0.119166567628337 0.42947998215065 no 1948 0.452571696519297 2698 789545
SGTC_406 estrone 100 µM -0.119427213164045 0.429364010456894 no 1949 0.452468451295359 2665 5870 A steroid.
SGTC_255 tunicamycin 200.472 nM -0.121037089428687 0.428647847166972 no 1950 0.451830829011771 2727 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3225 9130819 49.47 µM -0.122807607573858 0.427860492636613 no 1951 0.451129724946437 2631 4547121
SGTC_663 1486-0733 13.9 µM -0.123719298110083 0.427455173028328 no 1952 0.450768765685468 2632 722445 YPR165W RHO1
SGTC_1765 st044815 90.4 µM -0.12389504269429 0.427377049244944 no 1953 0.450699189031979 2701 645695
SGTC_2133 5320837 200 µM -0.124584556031865 0.427070567242993 no 1954 0.450426227814575 2724 2841355
SGTC_2911 7942208 15.64 µM -0.12520380872187 0.426795352929993 no 1955 0.450181101025037 2711 1243384
SGTC_2663 amphotericin b 100 µM -0.126062710478661 0.426413690459079 no 1956 0.4498411423301 2634 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1863 st057641 20.1 µM -0.127315941505627 0.425856927131893 no 1957 0.449345171742036 2625 3921635
SGTC_1326 1431-2094 10.8 µM -0.127637892811572 0.42571392011057 no 1958 0.449217771124458 2622 616278
SGTC_2271 7849410 118.62 µM -0.127813004145126 0.425636141796419 no 1959 0.449148479327178 2598 972430
SGTC_3025 9087895 49.47 µM -0.128007954449438 0.425549555110959 no 1960 0.449071339046118 2684 17173641
SGTC_3119 9125183 49.47 µM -0.128458757196153 0.425349345966003 no 1961 0.448892967370815 2624 22695334
SGTC_3353 9151644 39.2805 µM -0.128584871278646 0.425293340006641 no 1962 0.448843068945188 2730 4909158
SGTC_583 1488-1091 88.9 µM -0.129139729264333 0.425046951236929 no 1963 0.448623542894522 2613 4303273
SGTC_24 0417-1663 219 µM -0.130642836311156 0.424379632837468 no 1964 0.448028927315601 2700 4329390
SGTC_1022 4477-0945 21.3 µM -0.131560124095899 0.423972500722178 no 1965 0.447666113829736 2649 4648966
SGTC_2759 disulfiram 3.38 µM -0.131598413523935 0.4239555079738 no 1966 0.447650970218499 2641 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_14 0354-0009 295 µM -0.133029528007889 0.423320484764156 no 1967 0.447085014030615 2608 1713507
SGTC_611 3453-1652 23.7 µM -0.133991552512803 0.422893720959397 no 1968 0.446704627158262 2653 1560575
SGTC_127 0180-0333 59.125 µM -0.134665691462995 0.422594719981087 no 1969 0.446438100143794 2624 771601
SGTC_3204 9114183 49.47 µM -0.135168462881887 0.422371754697707 no 1970 0.446239340598541 2626 17027248
SGTC_92 0063-0024 660.874 µM -0.135317917830861 0.422305480334852 no 1971 0.446180259496647 2591 3594437
SGTC_1417 3966-0327 90.4 µM -0.135882050355727 0.422055341017376 no 1972 0.445957262796679 2678 651118
SGTC_1481 3346-2004 36 µM -0.136251390786196 0.421891590558523 no 1973 0.445811274978731 2656 2770522
SGTC_2423 st077119 87.2 µM -0.136758872026449 0.421666616137129 no 1974 0.445610696742549 2579 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2342 7990637 118.86 µM -0.13692179462469 0.421594395402716 no 1975 0.445546305730565 2756 2033102 YER133W GLC7
SGTC_2893 9048488 25.97 µM -0.136954872959451 0.421579732678248 no 1976 0.445533232535676 2665 6467338
SGTC_805 3852-0218 479 µM -0.137173324529548 0.421482901780766 no 1977 0.445446897756157 2664 6615355
SGTC_1317 1273-0028 910 nM -0.137734574750368 0.421234143651074 no 1978 0.445225096554582 2666 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_487 nimodipine 119 µM -0.138559460889689 0.420868593514189 no 1979 0.444899139869861 2636 4497 L-type voltage-gated calcium channels inhibitor
SGTC_310 1273-0058 1.06 µM -0.139465928406037 0.42046696908717 no 1980 0.444540988984896 2705 2734232
SGTC_2152 5568786 200 µM -0.140278366075206 0.420107076369729 no 1981 0.444220028335701 2633 5399883
SGTC_1694 st024011 44.9 µM -0.141156128072846 0.419718321426117 no 1982 0.443873301848747 2679 2787533
SGTC_786 4544-0069 423 µM -0.141488629401773 0.419571079238123 no 1983 0.443741971051286 2780 748821 YLR208W SEC13
SGTC_776 4476-4378 112 µM -0.141555221718741 0.419541591390089 no 1984 0.443715669275719 2753 2892008
SGTC_2930 9013230 14.89 µM -0.141657990182606 0.419496085212578 no 1985 0.443675079598233 2741 2995857
SGTC_2603 homopterocarpin 100 µM -0.142377217579761 0.419177639376769 no 1986 0.44339102839297 2764 101795 A weak amylase inhibitor.
SGTC_432 NS 1619 61.3 µM -0.142819892747911 0.418981666384706 no 1987 0.443216212998014 2828 4552 A K+/calcium channel activator.
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.143323160418941 0.418758893415082 no 1988 0.443017482643523 2684 641818 YHR062C RPP1
SGTC_966 1300-0360 30.2 µM -0.14342308151486 0.418714666134407 no 1989 0.442978027501792 2675 70588
SGTC_2234 tolnaftate 200 µM -0.143708309245509 0.418588423704585 no 1990 0.44286540474197 2679 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1919 st067113 52.3 µM -0.145888013470203 0.417623959532778 no 1991 0.442004897106377 2798 1268243
SGTC_1183 1254-0324 198 µM -0.146261796037121 0.417458619760998 no 1992 0.441857361908252 2783 5799357
SGTC_2393 9031399 185.94 µM -0.146843441583289 0.417201362471094 no 1993 0.441627797450218 2784 1526623 YDL150W RPC53
SGTC_2848 9016370 25.97 µM -0.147089028048287 0.417092752127952 no 1994 0.441530875015934 2686 7894410
SGTC_1496 4469-0713 57.4 µM -0.147538342308787 0.416894059773598 no 1995 0.441353559033478 2671 746691
SGTC_1967 st070177 51.4 µM -0.147765406818344 0.416793657094041 no 1996 0.441263955470297 2811 5729214
SGTC_2300 7976697 71.57 µM -0.147788534550199 0.416783430849845 no 1997 0.441254829037911 2706 2236109
SGTC_160 3453-0671 289.699 µM -0.147956890060552 0.416708991846654 no 1998 0.441188395223986 2690 5322268
SGTC_974 1326-0144 138 µM -0.148429652457617 0.416499974204328 no 1999 0.44100184998735 2687 5411856
SGTC_2079 5212404 121 µM -0.148604006250397 0.416422894886342 no 2000 0.440933055792241 2704 758462
SGTC_1389 3405-0187 19 µM -0.149602829521849 0.415981391431637 no 2001 0.440538987837226 2738 799890
SGTC_1581 himbacine 57.9 µM -0.150108847164994 0.415757760116253 no 2002 0.440339370023548 2668 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1289 0976-0073 69.1 µM -0.150245680574254 0.415697292134087 no 2003 0.440285393507938 2785 3391136
SGTC_3107 9121808 49.47 µM -0.152750748262318 0.414590633135213 no 2004 0.439297419498491 2662 662681
SGTC_2227 7312221 64.1025 µM -0.153077885223271 0.414446164293863 no 2005 0.439168427678381 2686 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_158 k038-0087 26.446 µM -0.154856567760102 0.413660873046903 no 2006 0.438467197208455 2680 X158
SGTC_2064 5220758 200 µM -0.156395112910958 0.412981881146923 no 2007 0.437860794554364 2829 788518
SGTC_2794 7785382 27.27 µM -0.156562032862911 0.412908231520759 no 2008 0.437795013421564 2663 2205081
SGTC_1857 st056007 79.3 µM -0.156565313888035 0.41290678387388 no 2009 0.437793720426495 2755 619834
SGTC_250 brefeldin a 552.239 µM -0.1577881376369 0.412367334841205 no 2010 0.437311873176063 2672 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_928 2764-0428 58.7 µM -0.157837876132393 0.412345396186395 no 2011 0.437292275946947 2810 662578
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.158632040469545 0.411995143335969 no 2012 0.436979391887839 2714 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2993 9054257 71.4286 µM -0.158761125705004 0.411938219074977 no 2013 0.436928538736717 2676 6470217 YGL055W OLE1
SGTC_1832 st054113 55 µM -0.159481589798951 0.411620541467049 no 2014 0.436644730944305 2689 1251267
SGTC_2228 7354201 200 µM -0.159664611282248 0.411539850165422 no 2015 0.436572639655265 2707 753451
SGTC_3033 9090887 49.47 µM -0.159866304420569 0.411450931157351 no 2016 0.43649319613045 2702 19325384
SGTC_793 0488-0545 106 µM -0.160123424248842 0.411337583176877 no 2017 0.436391924682019 2681 292548
SGTC_2418 pentamidine 31.67 µM -0.160604459078592 0.411125545018636 no 2018 0.436202471328412 2657 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2363 9053361 176 µM -0.16086102729326 0.411012461426038 no 2019 0.436101429100243 2826 6469797 YMR079W SEC14
SGTC_853 0419-0306 21 µM -0.162394954862035 0.410336530539128 no 2020 0.435497421771735 2681 762713
SGTC_2949 9072542 2.23 µM -0.164255018532885 0.409517243934332 no 2021 0.434765195340364 2790 16457352
SGTC_815 1582-0027 36.9 µM -0.164947787988878 0.409212206355705 no 2022 0.434492539073841 2782 3128206
SGTC_3217 9129673 49.47 µM -0.165284376499109 0.40906402082817 no 2023 0.434360077718076 2857 17248312
SGTC_2732 terfenadine 20 µM -0.165965180311947 0.408764331769152 no 2024 0.434092176093091 2690 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1874 staurosporine 7.6 µM -0.166377966376596 0.408582649777767 no 2025 0.433929756280423 2819 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_308 4092-1169 104 µM -0.166671537480322 0.408453450529367 no 2026 0.433814251018332 2712 2268590 YDL196W YDL196W
SGTC_1363 1636-0063 10.4 µM -0.167294901715495 0.408179143901269 no 2027 0.433569007725855 2703 6072185
SGTC_2951 9072950 58.06 µM -0.16753018151143 0.408075622528322 no 2028 0.433476450842386 2694 16488155
SGTC_2913 7966556 36.57 µM -0.168570923383092 0.407617780847695 no 2029 0.43306707649803 2711 2976516
SGTC_1125 tnp00248 1.32998 µM -0.170147486693671 0.4069244618439 no 2030 0.432447074479851 2876 24207736
SGTC_2221 6807166 181.081 µM -0.170424328153947 0.406802746406338 no 2031 0.432338220449317 2717 674925
SGTC_2777 climbazole 1.536 µM -0.170683157490277 0.406688958276999 no 2032 0.432236453429028 2728 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1292 0kpi-0043 232 µM -0.17176356566782 0.406214067830692 no 2033 0.431811705072746 2768 3333905
SGTC_349 k015-0014 24 µM -0.172307917862441 0.40597485153216 no 2034 0.431597729949758 2710 2196908
SGTC_3 0833-0587 95.581 µM -0.17251092174652 0.405885650185525 no 2035 0.431517937883965 2735 5382644
SGTC_3211 9128781 49.47 µM -0.172588417176337 0.405851599432352 no 2036 0.431487478511757 2852 17194361
SGTC_837 0091-0265 12.5 µM -0.173277942179895 0.405548660110821 no 2037 0.431216480505151 2715 759367
SGTC_300 r073-0011 5.04 µM -0.174561771254409 0.404984767139982 no 2038 0.430711994702604 2729 2735780
SGTC_2429 5902844 64.44 µM -0.174653104217753 0.40494465869622 no 2039 0.430676109344697 2864 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2046 4110841 106 µM -0.176022724156582 0.40434331649011 no 2040 0.430138044941047 2807 44119630 YMR134W ERG29
SGTC_2654 protoveratrine a 100 µM -0.176504939785487 0.404131649696665 no 2041 0.429948634110029 2716 5702278 A heart drug and vasodilator.
SGTC_441 propafenone 146 µM -0.177023293035387 0.40390415172433 no 2042 0.429745046660707 2704 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2677 mitomycin C 100 µM -0.177515889652033 0.403687988094433 no 2043 0.429551592648676 2737 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_938 3126-1755 342 µM -0.178337159335876 0.403327659991808 no 2044 0.429229098802902 2764 1777771
SGTC_1973 st070275 50.2 µM -0.178616694322078 0.403205034071141 no 2045 0.429119342561901 2676 17118334
SGTC_3301 9125354 19.7965 µM -0.178926667702136 0.403069066618118 no 2046 0.42899764143873 2717 41905162
SGTC_1574 spiramycin 23.7 µM -0.179479521534434 0.40282659061249 no 2047 0.428780597844428 2692 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_3092 9117248 49.47 µM -0.180239751624489 0.40249322255401 no 2048 0.428482176069904 2722 17141857
SGTC_1617 st002906 78 µM -0.180388152337793 0.402428155705506 no 2049 0.428423927412541 2711 5150859
SGTC_3038 9091290 49.47 µM -0.180607977485142 0.402331777514573 no 2050 0.428337646867838 2855 25236843
SGTC_2172 5754775 163.918 µM -0.180741750910557 0.402273129983911 no 2051 0.42828514297708 2749 2263357
SGTC_2517 totarol 10 µM -0.181038273360645 0.402143139590902 no 2052 0.428168767271616 2801 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_129 0088-0017 176.636 µM -0.181327749019001 0.402016248830834 no 2053 0.428055163235659 2773 182446
SGTC_330 1488-0319 80.1 µM -0.181403910073068 0.401982865583589 no 2054 0.428025275000947 2789 6846614
SGTC_2033 5192550 145 µM -0.182019037962313 0.401713266260246 no 2055 0.427783892668566 2764 182073
SGTC_178 4092-0806 87.505 µM -0.183819206887333 0.400924554247366 no 2056 0.427077643983697 2724 2169044
SGTC_1226 3909-7979 35.4 µM -0.183898417551672 0.400889858751217 no 2057 0.42704657312453 2857 6615510
SGTC_1767 st044992 70.3 µM -0.184958555053222 0.400425577478232 no 2058 0.426630771457172 2785 9600693
SGTC_2003 4023581 200 µM -0.185015297880636 0.400400731235372 no 2059 0.426608518372312 2853 16641307
SGTC_627 1391-0720 175 µM -0.187685568048904 0.399231945199581 no 2060 0.425561572123804 2832 997839
SGTC_278 4092-0821 23.9 µM -0.189353805022474 0.398502209844786 no 2061 0.424907763841495 2822 877900
SGTC_2925 9010536 32.5 µM -0.189398113823663 0.398482832712052 no 2062 0.424890401333484 2819 2994177
SGTC_727 3032-0951 202 µM -0.189859533677748 0.398281059383172 no 2063 0.424709601543249 2813 3652836
SGTC_2370 9071495 200 µM -0.189893623284765 0.398266153487904 no 2064 0.424696244718552 2812 21791103
SGTC_1980 st071811 45.7 µM -0.189998597376691 0.398220253837876 no 2065 0.424655114821466 2894 4974850
SGTC_947 3447-0010 211 µM -0.190361954471452 0.398061387766235 no 2066 0.424512754221415 2699 748350
SGTC_2799 7812892 81.82 µM -0.19090754471546 0.397822877920771 no 2067 0.424299014530691 2908 20205235
SGTC_299 1273-0059 1.44 µM -0.193782248550041 0.396566807041927 no 2068 0.423173193572141 2850 2848077
SGTC_539 4859-0462 2.54 µM -0.194003552750094 0.396470154856243 no 2069 0.423086550031997 2924 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1359 1582-0056 520 nM -0.194193818576184 0.396387063426082 no 2070 0.423012061402131 2852 3661189
SGTC_2608 thymoquinone 42.66 µM -0.194358175999158 0.396315290302914 no 2071 0.42294771806749 2714 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1664 st014217 9.02 µM -0.194724540278594 0.396155315602426 no 2072 0.422804299639312 2758 3982782
SGTC_466 geldanamycin 89.2 µM -0.194755296177005 0.39614188668868 no 2073 0.422792260277377 2803 5288382 HSP90 inhibitor.
SGTC_1304 1165-0502 251 µM -0.194841623080571 0.39610419452718 no 2074 0.42275846809312 2792 767425
SGTC_16 erodoxin 22.806 µM -0.195813320328875 0.395679997923597 no 2075 0.422378141894711 2775 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2900 5328528 85.29 µM -0.196719891182072 0.395284343777558 no 2076 0.422023371667716 2746 795359
SGTC_1604 st002052 72.4 µM -0.197970383804457 0.394738769248068 no 2077 0.421534117706329 2874 6254834 YHR062C RPP1
SGTC_224 benfluorex 43.875 µM -0.19819109393291 0.394642497532822 no 2078 0.421447777646774 2852 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_505 gw-5074 63.9 µM -0.199736948248113 0.393968390840851 no 2079 0.420843157731339 2867 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2551 apiole 73.87 µM -0.200464089847269 0.393651413074149 no 2080 0.420558820045281 2748 10659 A possible DNA adduct former.
SGTC_3252 9135871 49.47 µM -0.200561741659405 0.393608849762654 no 2081 0.420520637939671 2900 17682838
SGTC_168 3970-0862 530.542 µM -0.200639247359738 0.393575068403821 no 2082 0.420490333547029 2844 3135186
SGTC_1889 st059080 5.18 µM -0.201037979363135 0.393401291157229 no 2083 0.420334438515389 2771 176925 Isolated from Daphnopsis sellowiana.
SGTC_1554 st069299 38.7 µM -0.202161036959621 0.392911949175456 no 2084 0.419895416097749 2832 24207999
SGTC_578 3460-0051 92 µM -0.204983814634338 0.391682748777628 no 2085 0.418792385286992 2767 2876744
SGTC_1120 ficusin 1.78878 µM -0.20513987003594 0.391614824654507 no 2086 0.418731423491234 2908 6199 A DNA cross-linker.
SGTC_3046 9092212 49.47 µM -0.208071615975192 0.390339379546128 no 2087 0.417586524647872 2756 25236637
SGTC_1922 5578187 25 µM -0.20877158800618 0.390035033217853 no 2088 0.417313276036898 3019 1350412
SGTC_1458 k015-0034 6.33 µM -0.209216826857473 0.389841479382772 no 2089 0.417139488577967 2828 3598957
SGTC_559 1550-0661 158 µM -0.211335245393823 0.388920937280305 no 2090 0.416312841050256 2858 5830875
SGTC_2595 hexamethylquercetagetin 100 µM -0.213996154249906 0.387765543876375 no 2091 0.415275028091287 2880 386331
SGTC_1104 tacrolimus 29.8 µM -0.215267136000929 0.387214020608003 no 2092 0.41477952532124 2792 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1019 4262-0212 3.4 µM -0.215503018136091 0.387111688136554 no 2093 0.414687579605936 2865 4677213
SGTC_1877 wortmannin 25 µM -0.215928400811864 0.386927164702446 no 2094 0.414521779314024 2916 312145 A covalent inhibitor of PI 3-kinase.
SGTC_552 k242-0005 476 µM -0.215953724715332 0.386916180449341 no 2095 0.414511909362457 2902 4088318
SGTC_1011 4112-3381 17.4 µM -0.216189838211858 0.386813770487359 no 2096 0.414419887096954 2957 2877139
SGTC_3237 9133362 49.47 µM -0.216598211478485 0.386636664568465 no 2097 0.414260739843095 2908 43845137
SGTC_3290 9121031 71.43 µM -0.218286384719125 0.385904777747893 no 2098 0.413602991054774 2832 17014854
SGTC_2352 9027995 87.8 µM -0.21861354218596 0.385762989512718 no 2099 0.413475551410506 2849 2997347
SGTC_2563 tomatine 8.54 µM -0.218854919027473 0.385658387908535 no 2100 0.41338153225884 2812 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2841 9004761 38.96 µM -0.219233807299397 0.385494211957005 no 2101 0.413233960787605 2812 2991039
SGTC_144 4161-2749 112.381 µM -0.220353073894567 0.385009342838787 no 2102 0.412798094392602 2792 797501 YMR168C CEP3
SGTC_3097 9117246 49.47 µM -0.221210272516007 0.384638123730321 no 2103 0.412464355536418 2798 16423892
SGTC_1833 st055984 71 µM -0.22146180599675 0.384529214496275 no 2104 0.412366436326698 2838 676288
SGTC_1387 3342-1166 1.8 µM -0.222864809320734 0.38392190802989 no 2105 0.411820362833022 2871 3418228
SGTC_1494 4358-1428 177 µM -0.224208255483394 0.383340648603986 no 2106 0.411297630020142 2935 1564571
SGTC_25 0118-0223 35.662 µM -0.224446243491956 0.383237707334205 no 2107 0.411205045644732 2939 5333628
SGTC_650 1328-0195 38 µM -0.225591813764479 0.382742308514921 no 2108 0.410759454204068 2829 2780821
SGTC_2325 6158266 200 µM -0.226623092147991 0.382296498925045 no 2109 0.410358417243006 2888 3623240
SGTC_2014 4013930 200 µM -0.227230747637333 0.382033889550793 no 2110 0.410122159903942 2827 64556
SGTC_3129 9127257 49.47 µM -0.227383391012938 0.381967930462318 no 2111 0.410062817060218 2843 837894
SGTC_561 1550-0330 72.9 µM -0.227984481765888 0.381708225047008 no 2112 0.409829152311225 2808 6812934
SGTC_2067 5224629 34.075 µM -0.228307332588196 0.381568757085634 no 2113 0.409703662251344 2959 2835000
SGTC_64 000l-0018 272.079 µM -0.228439558985324 0.381511641190852 no 2114 0.409652269361453 2773 6811119
SGTC_3125 9127534 49.47 µM -0.228469972050592 0.381498504470643 no 2115 0.40964044883002 2777 1639235
SGTC_2610 ononetin 44.17 µM -0.228597865485669 0.381443263250607 no 2116 0.409590741869757 2872 259632
SGTC_1789 tunicamycin 25 nM -0.228670734629422 0.381411789842418 no 2117 0.409562421256411 2928 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3077 9117319 49.47 µM -0.229683226905953 0.380974558641179 no 2118 0.409168964741643 2789 17154678
SGTC_2903 5923464 63.88 µM -0.229964813416623 0.380852986264148 no 2119 0.409059555906772 2904 2876576
SGTC_1971 st069429 63.5 µM -0.23094290249719 0.380430796784326 no 2120 0.408679580060203 2963 1246522 YGL099W LSG1
SGTC_331 k048-0133 24.5 µM -0.231166848569466 0.38033415108871 no 2121 0.408592591765917 2805 6813582
SGTC_1065 prochlorperazine maleate 2.48 µM -0.23402982406739 0.379099271518454 no 2122 0.407480912617482 2833 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.234364858533958 0.378954842332088 no 2123 0.407350868900702 2833 4174840
SGTC_2371 9071574 200 µM -0.235671658751198 0.37839165870838 no 2124 0.406843731763503 2919 45596039
SGTC_2964 9083345 53.42 µM -0.235996964172678 0.378251503933944 no 2125 0.406717512945588 2869 17741579
SGTC_49 0717-0965 32.132 µM -0.236209191427135 0.378160076454475 no 2126 0.406635173787714 3110 5889349 YGL099W LSG1
SGTC_811 0416-0114 265 µM -0.236947825602908 0.37784192614939 no 2127 0.40634863339232 2909 6612453
SGTC_1126 isoteolin 1.0172 µM -0.237809190068642 0.377471017135683 no 2128 0.406014545242544 2828 133323
SGTC_3051 9093778 49.47 µM -0.239898662200157 0.376571747203722 no 2129 0.405204408994769 2819 17217378
SGTC_905 2-aminofluorene 215 µM -0.240079624902952 0.376493895652717 no 2130 0.405134264661778 2828 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1787 fluconazole 80 µM -0.240224724612565 0.37643147626673 no 2131 0.405078023658248 2878 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1144 3486-0183 12.5 µM -0.240533425382494 0.376298689285323 no 2132 0.404958377005474 2839 6744069
SGTC_3298 9116858 71.43 µM -0.242440211578985 0.375478814298377 no 2133 0.40421953960775 2978 2506942
SGTC_3275 9138069 49.47 µM -0.243669732664774 0.374950445820019 no 2134 0.403743308356035 2910 17617007
SGTC_666 0272-0154 136 µM -0.243703998855498 0.374935723787831 no 2135 0.403730038048843 2881 6870312
SGTC_1090 efavirenz 20.7 µM -0.243744434742579 0.374918351258628 no 2136 0.403714378538775 2885 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2084 5306078 60.6385 µM -0.244387900777985 0.374641932181754 no 2137 0.40346520575961 2899 679340
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.244941248237671 0.374404277591681 no 2138 0.403250961406689 2857 2724 A muscle relaxant with antifungal properties.
SGTC_576 1073-0113 22.7 µM -0.245661930907378 0.374094826535309 no 2139 0.402971971968068 2884 5439563
SGTC_1934 st074720 32.6 µM -0.245758235732634 0.374053480730202 no 2140 0.402934694347271 2829 17250992
SGTC_2717 st081029 62.2815 µM -0.248157299021942 0.373023978191825 no 2141 0.402006351774645 2948 5292846
SGTC_89 0302-0250 142.109 µM -0.249552699000496 0.372425590819736 no 2142 0.401466641017273 2821 4203518 YLR208W SEC13
SGTC_1382 3002-2117 298 µM -0.250977272912972 0.371815010380148 no 2143 0.400915840258115 2995 1497314
SGTC_2406 ethylparaben 405.7 µM -0.251013286283133 0.371799579016114 no 2144 0.400901918507432 2788 8434 A possible steroid mimic.
SGTC_454 lyso-paf C-16 6.67 µM -0.251840639871487 0.371445123155166 no 2145 0.400582121692659 2925 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1740 st038286 13.222 µM -0.252534011758283 0.371148151829856 no 2146 0.400314164105043 3066 716786
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.254024805766255 0.370509904415967 no 2147 0.399738197144466 2831 803109
SGTC_2566 crystal violet carbinol 226 nM -0.254933991520803 0.370120833281809 no 2148 0.399387041001552 3019 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.255672992552624 0.369804687775812 no 2149 0.399101675498293 2984 521171
SGTC_626 0214-0009 33 µM -0.255933679980511 0.369693186369334 no 2150 0.399001023814005 2969 3437874
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.256737330029839 0.369349517601972 no 2151 0.398690775990586 2897 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1493 4348-0038 111 µM -0.257011052271439 0.369232488249003 no 2152 0.398585120557901 2905 800424
SGTC_13 0199-0087 65 µM -0.257105602017709 0.369192066524691 no 2153 0.398548626549774 2853 4589825
SGTC_3143 9086658 49.47 µM -0.258023040897257 0.368799919999573 no 2154 0.398194562543447 2920 25236626
SGTC_2051 5263410 176 µM -0.258876316110319 0.368435321896624 no 2155 0.397865336210241 2884 227584
SGTC_2446 5162541 200 µM -0.259359180914005 0.368229049834741 no 2156 0.397679060636063 2831 1549321
SGTC_425 3825-7017 13.1 µM -0.261021850684436 0.367519074977717 no 2157 0.397037828401305 3119 3397440
SGTC_1155 4088-0394 48.2 µM -0.261433791679193 0.36734324235079 no 2158 0.396879000442645 2822 2326248
SGTC_678 1218-2179 85.9 µM -0.262838111237411 0.366744032719176 no 2159 0.396337679725506 2880 6820081 YOR116C RPO31
SGTC_1943 st076331 65.2 µM -0.263860616414687 0.36630794371954 no 2160 0.395943661985455 2971 24208415
SGTC_295 k015-0027 31 µM -0.264693508773881 0.365952850352655 no 2161 0.395622789221634 2942 3887424
SGTC_1028 k015-0029 4.8 µM -0.265644967275687 0.365547348254377 no 2162 0.395256325276005 2854 4588309
SGTC_691 1548-0686 185 µM -0.266240798194112 0.365293487536419 no 2163 0.395026882059211 2893 46495133
SGTC_266 formosanin C 406 nM -0.267443084649483 0.364781419131322 no 2164 0.394564015176537 2998 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2208 7283366 200 µM -0.267517651855251 0.364749667984475 no 2165 0.394535312527987 2968 898663
SGTC_632 0781-2353 4.65 µM -0.267777338341814 0.364639099220685 no 2166 0.394435357640819 2969 6811515 YHR007C ERG11
SGTC_42 0133-0086 60.653 µM -0.268505493664566 0.364329126858525 no 2167 0.394155123374811 2830 162923 Model of phenazepam hydroxylation.
SGTC_2482 5981709 142.65 µM -0.268509070245827 0.364327604543157 no 2168 0.394153747044482 2927 877755
SGTC_1021 4476-0760 85.3 µM -0.268639962622833 0.364271893741231 no 2169 0.394103378303369 2896 746768
SGTC_1257 0669-0121 16 µM -0.270031394121475 0.363679846015753 no 2170 0.393568050706828 2977 4307855
SGTC_1167 k781-0610 148 µM -0.271965483712988 0.362857440441852 no 2171 0.392824279667348 2941 4525169
SGTC_2853 9015042 58.44 µM -0.272568508626744 0.362601153775186 no 2172 0.392592461035564 2826 6457456
SGTC_2640 pentamidine 10.38 µM -0.273792464154916 0.362081159836973 no 2173 0.39212205757689 3001 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3061 glucosamine 200 µM -0.274508946616919 0.361776882358772 no 2174 0.391846764596981 2973 91431 and experimental redox chemotherapeutic
SGTC_667 1498-1044 59 µM -0.27497394897194 0.36157945078866 no 2175 0.391668126403112 2930 6739982
SGTC_2815 7968870 71.43 µM -0.276384507922365 0.360980778637269 no 2176 0.391126377186028 2890 2977326 YHR190W ERG9
SGTC_1448 4255-0083 152 µM -0.277422684824248 0.360540370973805 no 2177 0.390727782490713 3046 5399660
SGTC_1003 4049-0218 100 µM -0.278075894447627 0.360263366001961 no 2178 0.390477049846211 3053 295161
SGTC_2821 7996764 71.43 µM -0.278439776760475 0.360109087137221 no 2179 0.39033739440579 3127 2987135
SGTC_1239 0337-0584 35.4 µM -0.281576736086316 0.358780025904094 no 2180 0.389134040306841 3082 914301 YML130C ERO1
SGTC_2883 9059145 45.46 µM -0.281810369977904 0.358681108469639 no 2181 0.389044459493514 2852 16476510
SGTC_1072 oxiconazole 14.9 nM -0.282649990801978 0.358325702634016 no 2182 0.388722577534181 2905 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2131 toluylene red 5.2905 µM -0.282727277139912 0.358292994010597 no 2183 0.388692952426513 2932 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_419 nsc-638432 893 µM -0.285270886321387 0.357217085753029 no 2184 0.387718307946351 2978 368090
SGTC_341 1486-1430 230 µM -0.285989670920421 0.356913255900529 no 2185 0.387443016360607 2880 2054753 YPL210C SRP72
SGTC_3091 9116372 49.47 µM -0.28669122068842 0.356616798695082 no 2186 0.387174380209833 3067 17169793
SGTC_122 0236-0016 402.397 µM -0.286796316689914 0.356572395234317 no 2187 0.387134141691502 2953 6808838
SGTC_2459 5811157 9.22 µM -0.288430964309642 0.355882000983635 no 2188 0.386508434135775 2892 2870684 YBR192W RIM2
SGTC_389 tpck 16.7 µM -0.2890743192045 0.355610409131113 no 2189 0.38626225267365 2990 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3083 9117465 49.47 µM -0.292695470758915 0.354083113053246 no 2190 0.384877466085479 3026 16420915
SGTC_1668 st014914 51.6 µM -0.292906613073554 0.353994131489608 no 2191 0.384796766969314 2987 2839556
SGTC_1161 k007-0610 110 µM -0.292946922538598 0.353977144805128 no 2192 0.384781361159067 3019 5843850
SGTC_2575 plumbagin 510 nM -0.295031284660611 0.353099177105829 no 2193 0.383984990558864 2881 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1438 4092-1045 4 µM -0.295119260162476 0.353062137528515 no 2194 0.383951388573746 2929 1351342
SGTC_2607 solasodine 47.35 µM -0.295615092863436 0.352853407347128 no 2195 0.383762023047925 2936 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_749 1000-0129 128 µM -0.295749943884632 0.352796646908129 no 2196 0.383710526333264 3083 708470
SGTC_960 1222-0186 7.7 µM -0.298212812775037 0.351760572857466 no 2197 0.382770371637348 3054 3126296
SGTC_1931 st074438 57.1 µM -0.299270969522832 0.351315767251731 no 2198 0.382366651535032 2873 2787313
SGTC_3167 9103034 49.47 µM -0.299575058393731 0.351187978418515 no 2199 0.382250655687908 2915 5127859
SGTC_1059 3448-6867 171 µM -0.29979216708389 0.351096752007715 no 2200 0.382167845223464 2906 3934407
SGTC_1497 4476-2978 41.3 µM -0.300060353546196 0.350984075189496 no 2201 0.382065559912305 3020 1528379
SGTC_1451 4152-0210 104 µM -0.300652740597043 0.350735234022364 no 2202 0.381839654891466 3102 659563
SGTC_492 tmb-8 126 µM -0.300843954295085 0.350654925470561 no 2203 0.381766744707887 2993 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_596 1155-0152 116 µM -0.301413636961917 0.350415701900685 no 2204 0.381549548384703 2967 280313
SGTC_2854 9024559 71.43 µM -0.30229221469287 0.350046882117505 no 2205 0.381214656338983 3031 3163529
SGTC_1233 0325-0408 14.2 µM -0.303018353872688 0.349742161512211 no 2206 0.380937937203497 3043 12874
SGTC_1055 3448-0672 86 µM -0.303119811839399 0.349699592894328 no 2207 0.380899278164196 3073 748378
SGTC_149 3970-0822 46.1 µM -0.30349391655996 0.349542646482629 no 2208 0.380756741437986 2962 3114250 YBL034C STU1
SGTC_1683 st010134 710 nM -0.30549763311687 0.348702474899866 no 2209 0.379993586183112 2928 3818134
SGTC_3227 9130768 49.47 µM -0.307040840600369 0.348055902980751 no 2210 0.379406143156657 2943 17720899
SGTC_96 0929-0093 37.281 µM -0.307132757274382 0.348017405713834 no 2211 0.379371162586645 2946 6991579
SGTC_451 chloral hydrate 100 µM -0.307407769636303 0.347902232221405 no 2212 0.379266507505059 3068 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_93 0109-0045 59.227 µM -0.307504766170963 0.347861614013589 no 2213 0.379229597891734 2921 88733
SGTC_721 1187-1332 279 µM -0.308482734664598 0.347452178155003 no 2214 0.37885751791961 2875 25730
SGTC_2031 5180455 200 µM -0.308542445566469 0.347427185373579 no 2215 0.378834803815178 2951 29949
SGTC_1461 k072-0203 53.8 µM -0.310285414357724 0.34669793558804 no 2216 0.378171960919413 2987 5418714
SGTC_2945 9067681 61.76 µM -0.311477698612524 0.346199416349541 no 2217 0.37771874709613 2924 16456930
SGTC_992 3909-8734 162 µM -0.31150093100832 0.346189705037124 no 2218 0.377709917614165 2999 4288319
SGTC_3002 9075603 71.4286 µM -0.312114742834622 0.34593316382953 no 2219 0.377476661325971 2959 20105405
SGTC_2171 5739187 198.077 µM -0.312245408606939 0.34587856150167 no 2220 0.377427012438992 2892 2262761
SGTC_56 0957-0365 83.25 µM -0.312656133778953 0.345706949438449 no 2221 0.37727096297594 3073 6752360
SGTC_1660 st012960 28.1 µM -0.314950124492679 0.34474904201411 no 2222 0.376399761455533 3047 24207266
SGTC_288 1315-0019 35.1 µM -0.31501722873905 0.344721036067815 no 2223 0.376374286357316 3050 6811474
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.316109406189313 0.344265335715375 no 2224 0.375959733717801 3112 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_294 k038-0071 157 µM -0.316461334074764 0.344118545365198 no 2225 0.375826184574035 3025 24152826
SGTC_2161 5662504 8.5105 µM -0.316830342947336 0.343964655698378 no 2226 0.375686169532436 2993 2859334
SGTC_1887 st057648 70.8 µM -0.317058711244577 0.343869431037564 no 2227 0.37559952670706 3092 688672
SGTC_47 0149-0135 24.25 µM -0.318614378827818 0.343221014944152 no 2228 0.375009474282623 2951 5239155
SGTC_2034 5197015 53.07 µM -0.318795947020353 0.343145365731059 no 2229 0.374940625931593 3115 780676
SGTC_1128 3448-9350 235 µM -0.319417206743705 0.34288656945058 no 2230 0.374705082297938 3036 619386
SGTC_167 3672-0051 66.205 µM -0.319577501281547 0.34281980799699 no 2231 0.374644316009382 2902 3237971
SGTC_2474 5321570 43.32 µM -0.319859682272242 0.342702293690625 no 2232 0.374537351172745 3086 2841384
SGTC_333 3486-0131 40.1 µM -0.320243703152151 0.342542392602948 no 2233 0.37439179794529 3124 6744690
SGTC_463 ikarugamyin 104 µM -0.320477150755754 0.342445201972965 no 2234 0.374303324388025 3015 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2793 7325131 81.82 µM -0.321156931302297 0.342162250152889 no 2235 0.374045734256802 3027 4176441
SGTC_980 1473-0395 201 µM -0.322542877941281 0.341585638392239 no 2236 0.37352072998806 2957 768876
SGTC_1855 st056195 39.6 µM -0.324308787961303 0.340851481400057 no 2237 0.372852133551467 3153 4028379
SGTC_3278 9139605 49.47 µM -0.3243419565069 0.340837697709186 no 2238 0.372839579166576 3154 7958859
SGTC_768 0384-0033 77.3 µM -0.326321223564454 0.340015568564218 no 2239 0.37209066612208 2990 3965305 YMR134W ERG29
SGTC_2652 actinonin 100 µM -0.327938184557005 0.339344494609159 no 2240 0.371479200836753 2959 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2739 tacrine 100.86 µM -0.328658621207301 0.339045661587135 no 2241 0.371206866902223 3076 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_2078 5212016 200 µM -0.331357715488602 0.337926994088429 no 2242 0.370187150281289 3021 1899708
SGTC_2021 4019055 173 µM -0.332841824794381 0.337312498250456 no 2243 0.36962684244874 3152 44827708 YER133W GLC7
SGTC_1311 1190-0148 100 µM -0.333394464108758 0.337083788529671 no 2244 0.36941827068748 3121 1961333
SGTC_7 0192-1582 4.227 µM -0.333589511541583 0.33700308254068 no 2245 0.369344666951382 3033 252616
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.333950855594762 0.336853586792141 no 2246 0.369208321635563 2966 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_744 1594-0068 283 µM -0.333960971862099 0.336849401847129 no 2247 0.369204504718878 3008 668392
SGTC_2400 5203494 178.7 µM -0.334089872085459 0.33679607956553 no 2248 0.369155871169086 2977 6777674
SGTC_1847 st056231 15 µM -0.335749922678355 0.336109658301476 no 2249 0.368529727996874 2983 5393180
SGTC_20 0481-0013 4.944 µM -0.335765968381438 0.33610302615797 no 2250 0.368523677527443 3036 182045
SGTC_2321 7390090 138.78 µM -0.336264930900099 0.33589681628792 no 2251 0.368335546392414 3052 649046
SGTC_3179 9107801 49.47 µM -0.336272683564286 0.335893612677506 no 2252 0.36833262354097 2986 4818259
SGTC_2060 5238662 140 µM -0.33973636737861 0.334463520573584 no 2253 0.367027535890905 3094 790130
SGTC_2168 5727979 200 µM -0.339773610064248 0.334448156744123 no 2254 0.367013511467938 2987 695210
SGTC_1647 st011722 22.4 µM -0.340777286646675 0.334034211727294 no 2255 0.366635625356169 3149 2854783
SGTC_1904 st060225 78 µM -0.341211048266995 0.333855378420572 no 2256 0.366472353266646 3020 66595
SGTC_318 1488-0629 67.2 µM -0.341962692347313 0.333545576372909 no 2257 0.366189484359277 3081 3662576
SGTC_71 0417-1750 47.813 µM -0.34220637194161 0.333445164305134 no 2258 0.366097795142927 3197 6811472
SGTC_2787 5284540 71.43 µM -0.342419618853732 0.333357302299982 no 2259 0.36601756309157 3054 736958
SGTC_2132 5317594 122.667 µM -0.343858545385703 0.332764674892403 no 2260 0.365476334444982 2989 794577
SGTC_671 0560-0003 407 µM -0.344015005418014 0.332700261374468 no 2261 0.365417500686974 3029 3238678
SGTC_1419 3993-2473 62.6 µM -0.34472450145915 0.332408228735056 no 2262 0.365150748229829 3050 704026
SGTC_630 4356-0227 183 µM -0.345113724510548 0.332248065485024 no 2263 0.365004437969135 3039 779312
SGTC_90 0870-0863 4.608 µM -0.346429661926028 0.331706791128687 no 2264 0.364509918300294 2975 1738164
SGTC_2176 5809774 33.9695 µM -0.347547584329859 0.33124724056626 no 2265 0.364089988265417 3132 2870539
SGTC_618 k072-0232 33.2 µM -0.34791834117324 0.331094887554139 no 2266 0.363950755264671 3094 5872756 YGL099W LSG1
SGTC_823 0417-1665 178 µM -0.348014352907257 0.331055438552345 no 2267 0.363914702210143 3094 3429856
SGTC_1950 st077106 7.18 µM -0.349760629645669 0.330338261443663 no 2268 0.363259174001031 3096 13831864
SGTC_2077 5212015 200 µM -0.350991424617653 0.329833161116215 no 2269 0.362797390906024 2982 780900
SGTC_120 rhodamine 6G 52.259 µM -0.351101276155206 0.329788094707799 no 2270 0.362756185292739 2991 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2583 asiatic acid 100 µM -0.354785903065018 0.328277917628151 no 2271 0.361374995000892 3206 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_369 0957-0393 4.5 µM -0.355220232906211 0.328100087822366 no 2272 0.361212304094795 3071 6997992
SGTC_640 3381-0960 37.1 µM -0.355627605938194 0.32793333047805 no 2273 0.361059733457271 3100 1745025
SGTC_1201 1889-3372 45.9 µM -0.356534142996374 0.327562364453057 no 2274 0.36072029367747 3038 5392199
SGTC_2368 9071271 200 µM -0.357661606629469 0.327101230026185 no 2275 0.360298284192135 3046 27209959
SGTC_2834 9001755 58.44 µM -0.357807924114963 0.327041405267084 no 2276 0.360243530040006 3053 2989575
SGTC_2425 5628681 7.85 µM -0.359021187992358 0.326545509989777 no 2277 0.359789619403506 3119 5714958
SGTC_774 k060-0086 136 µM -0.359346300112897 0.326412679474714 no 2278 0.359668020847918 3221 5911235
SGTC_218 alverine citrate 93.75 µM -0.361044745872871 0.325719106497937 no 2279 0.359032998743866 3174 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1227 3909-8010 46.6 µM -0.361644284770714 0.325474424150586 no 2280 0.358808933476728 3041 15982272
SGTC_1077 5-fluorocytosine 377 nM -0.361856535830787 0.325387818785066 no 2281 0.358729620670609 3102 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_61 0978-8327 98.565 µM -0.362937959404331 0.324946709119833 no 2282 0.3583256149177 3150 6150059 YHR072W ERG7
SGTC_554 4483-2211 187 µM -0.36294397955247 0.324944254204183 no 2283 0.358323366312169 3123 747107
SGTC_816 0325-0417 81.3 µM -0.363846786707335 0.324576190650134 no 2284 0.357986211467287 3093 68101
SGTC_237 nikkomycin 200 µM -0.364119018316854 0.324465238707503 no 2285 0.357884567834755 3180 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_439 amiodarone 34.4 µM -0.364771372222858 0.324199425820939 no 2286 0.357641038229686 3054 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1808 st050063 61.5 µM -0.365275505237794 0.323994069455538 no 2287 0.357452880508427 3193 4011993
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.36562548817851 0.323851536933163 no 2288 0.357322276639313 3172 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_919 tnp00227 403.569 nM -0.367585434818757 0.32305381541633 no 2289 0.356591188465316 3051 1269246 A methoxyflavone. YNL221C POP1
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.367981129186136 0.3228928616603 no 2290 0.356443652599601 3070 115019
SGTC_1106 tegaserod maleate 11.7 µM -0.367984891276149 0.322891331541081 no 2291 0.356442249995787 3097 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1029 k015-0030 64.7 µM -0.36805089428646 0.32286448724989 no 2292 0.356417642693651 3161 2208316
SGTC_2449 5812982 45.77 µM -0.369500052169262 0.32227532848867 no 2293 0.355877517143623 3146 776185
SGTC_647 0140-0236 81 µM -0.370573806744621 0.321839078561411 no 2294 0.355477497163909 3097 990837
SGTC_3115 9123671 49.47 µM -0.371802701049478 0.321340098981021 no 2295 0.355019876243104 3164 3286988
SGTC_3055 9094636 49.47 µM -0.371956574060875 0.321277643151914 no 2296 0.354962591066374 3241 25236176
SGTC_2978 9011784 42.97 µM -0.372210819211523 0.32117445814595 no 2297 0.354867945665329 3145 2994934
SGTC_2142 5622915 118.518 µM -0.372379246763867 0.321106109682076 no 2298 0.354805251689051 3094 5322196
SGTC_870 0573-2213 57.6 µM -0.372981216994751 0.320861877697338 no 2299 0.354581211787054 3090 3916321
SGTC_1352 1496-0991 99 µM -0.373112096931587 0.320808787207443 no 2300 0.354532507845984 3055 3000039
SGTC_272 doxorubicin 8.13 µM -0.373863031577145 0.320504246911483 no 2301 0.354253110879083 3083 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3340 9146634 11.102 µM -0.374554254739933 0.320224029279735 no 2302 0.353995999821231 3150 4907387
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.375030431414321 0.320031049788695 no 2303 0.353818917315417 3063 5106787 A p450 inhibitor.
SGTC_1800 st050079 29.0735 µM -0.375797133275554 0.31972043185424 no 2304 0.353533859588621 3161 3645560
SGTC_1552 6-methylflavone 10.6 µM -0.376019495708797 0.319630368634632 no 2305 0.353451201179123 3154 689013
SGTC_1873 rapamycin 2 nM -0.37677600869497 0.319324038657109 no 2306 0.35317003566572 3085 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_716 1683-5115 658 µM -0.376864835183967 0.319288078797559 no 2307 0.353137027678922 3090 723597
SGTC_1486 3970-0793 4.53 µM -0.377233335207837 0.31913891612751 no 2308 0.353000104609366 3154 2844330
SGTC_859 0439-0102 54.6 µM -0.380876365235222 0.317665856854047 no 2309 0.351647495414566 3196 610143
SGTC_413 propylparaben 100 µM -0.381198386514052 0.317535785835125 no 2310 0.351528023138038 3064 7175 A pharmaceutical preservative.
SGTC_21 0849-0113 22.993 µM -0.38231196054684 0.317086164067479 no 2311 0.351114992040243 3078 1560156
SGTC_765 1319-0117 244 µM -0.383358386103613 0.316663900430649 no 2312 0.350727026917085 3066 3487746 YGL099W LSG1
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.384196468036872 0.316325881779409 no 2313 0.350416417958491 3138 676296 Flavone; oxidizing agent.
SGTC_1850 st056238 17 µM -0.385466188275788 0.315814065315265 no 2314 0.349946026280599 3105 5393177
SGTC_3155 9099265 49.47 µM -0.385779028295997 0.315688015572232 no 2315 0.349830164143892 3186 25236499
SGTC_1705 st027868 56.3335 µM -0.386398141723335 0.315438625109907 no 2316 0.349600913079458 3140 292948
SGTC_1374 2889-5571 141 µM -0.386558503917982 0.315374041920585 no 2317 0.349541541616325 3134 2853281
SGTC_1991 st073000 8.92 µM -0.387043493055421 0.315178754996012 no 2318 0.349362004772328 3270 4301969 YIL048W NEO1
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.387077768828271 0.315164955381689 no 2319 0.349349317589288 3063 3256 An antibiotic and ribosome inhibitor.
SGTC_405 ebelactone b 50 µM -0.388213694294456 0.314707771563989 no 2320 0.34892894989079 3111 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_943 3253-1379 105 µM -0.388385326550637 0.314638718207871 no 2321 0.348865450687874 3261 668464
SGTC_1675 st018485 24.5 µM -0.388620373287313 0.314544161618461 no 2322 0.348778496743238 3119 3323024
SGTC_3153 9100258 49.47 µM -0.388961846971081 0.314406812368379 no 2323 0.34865218502395 3082 25236848
SGTC_338 4055-0136 114 µM -0.390127590623782 0.313938114758186 no 2324 0.348221100851973 3079 2900563
SGTC_3020 9089140 49.47 µM -0.391374272108547 0.313437207343251 no 2325 0.347760303319455 3202 17217859
SGTC_2293 7624732 200 µM -0.392285403978863 0.313071338728171 no 2326 0.347423673534114 3063 894453
SGTC_2195 6536160 144.242 µM -0.392633836444502 0.312931472900968 no 2327 0.347294972311875 3077 3834386
SGTC_2179 6298986 200 µM -0.39383801853572 0.312448304194315 no 2328 0.346850316724579 3210 738374
SGTC_2969 9091408 28.7 µM -0.39516291908261 0.311917070458761 no 2329 0.346361328322412 3060 4286311
SGTC_1036 k216-0215 33.5 µM -0.395182664343007 0.311909156329616 no 2330 0.346354042763324 3064 622330
SGTC_206 4546-0025 72.014 µM -0.395866325663375 0.311635190527759 no 2331 0.346101822116605 3178 6620745 YIL048W NEO1
SGTC_885 0865-0106 16.8 µM -0.396025408831851 0.311571455561496 no 2332 0.346043141935555 3087 2793380
SGTC_177 1327-0068 8.361 µM -0.39780907138289 0.310857237126468 no 2333 0.345385464987991 3213 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_957 1187-1561 14.1 µM -0.399118876899416 0.310333214854422 no 2334 0.344902806865633 3201 1538454
SGTC_2375 9072683 200 µM -0.400124592396912 0.309931112907721 no 2335 0.344532375873635 3289 16798029
SGTC_834 0312-0008 75.7 µM -0.400761648359825 0.309676524765545 no 2336 0.344297808791423 3115 6385573 YIL048W NEO1
SGTC_136 0097-0015 404.482 µM -0.401270647320725 0.309473177930912 no 2337 0.344110435946037 3209 4861337
SGTC_1583 clindamycin 39.6 µM -0.402838749447601 0.30884708254942 no 2338 0.343533426451498 3110 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_67 0335-0847 266 µM -0.403952128632372 0.308402881011337 no 2339 0.343123961028006 3383 4552207 YOR254C SEC63
SGTC_3065 9113888 49.47 µM -0.404562411224041 0.308159517307444 no 2340 0.342899596609427 3298 16648368
SGTC_1397 3532-0190 20.1 µM -0.404614366272032 0.308138802974037 no 2341 0.342880498402212 3042 5322280
SGTC_161 4065-0411 162.148 µM -0.406616829002888 0.307340892818275 no 2342 0.342144717499305 3217 1906281 YLR208W SEC13
SGTC_3023 9089636 49.47 µM -0.407329794195336 0.307057021279268 no 2343 0.341882891433658 3232 17249241
SGTC_2995 9067767 71.4286 µM -0.407813229991211 0.30686460406199 no 2344 0.341705399936278 3165 11673567
SGTC_1159 4092-0538 61.2 µM -0.409269523363731 0.306285291516755 no 2345 0.341170939308739 3141 717301
SGTC_2244 6635614 200 µM -0.409711798229976 0.306109450604545 no 2346 0.341008687140753 3002 836499
SGTC_1679 SEC14.276 6.7 µM -0.409869169744267 0.306046893157398 no 2347 0.340950961197901 3228 1005053 YMR079W SEC14
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.411144945356036 0.305539962867151 no 2348 0.34048312745441 3281 1273210
SGTC_790 1575-0012 79.1 µM -0.411697917767396 0.305320354587763 no 2349 0.340280425687504 3264 378741 YLR208W SEC13
SGTC_334 1502-1024 68.5 µM -0.411798265745416 0.305280509751044 no 2350 0.340243646315425 3226 3296216
SGTC_2257 7960413 200 µM -0.411986916369316 0.305205609123498 no 2351 0.340174506520675 3104 2974689 YIL048W NEO1
SGTC_867 0518-0118 155 µM -0.412144982706344 0.305142857764242 no 2352 0.340116579897493 3237 6848158
SGTC_2582 agaric acid 100 µM -0.412612517524519 0.304957282862266 no 2353 0.339945264349519 3225 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1835 st008666 49.2 µM -0.412657138685561 0.30493957435824 no 2354 0.339928915853192 3099 690455
SGTC_2749 bexarotene 57.39 µM -0.41291768320987 0.304836182904642 no 2355 0.33983346242111 3184 82146 An retinoic acid receptor inhibitor.
SGTC_497 capsazepine 133 µM -0.413173040638048 0.304734864957607 no 2356 0.339739919304344 3150 2733484 A calcium channel blocker.
SGTC_345 1362-0200 395 µM -0.413798846990945 0.304486627637663 no 2357 0.33951071423017 3139 1419823
SGTC_1175 0741-0056 27.6 µM -0.417211375304161 0.30313457337645 no 2358 0.338261902761364 3317 765927
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.417675469579626 0.302950905394017 no 2359 0.338092204883764 3148 6708784 An antioxidant flavonoid
SGTC_2768 sulfasalazine 50.2 µM -0.418245226128169 0.302725489092255 no 2360 0.337883916164372 3298 5384001 An antioxidant and salicylic acid derivative.
SGTC_1154 4088-0362 150 µM -0.421744926318338 0.301342532434382 no 2361 0.336605604213307 3119 6618304
SGTC_2642 cholecalciferol 100 µM -0.425733031142426 0.299770053041373 no 2362 0.335151195117138 3231 9821465 A vitamin D precursor, similar to steriods.
SGTC_1830 st055982 50.3 µM -0.427135854783065 0.299217815110076 no 2363 0.334640189489452 3265 455313 An antimicrobial agent.
SGTC_5 0352-0601 109.883 µM -0.428106357406188 0.2988360357686 no 2364 0.334286844235665 3194 762456
SGTC_1425 4048-4433 7.33 µM -0.428929537448439 0.29851238424491 no 2365 0.333987251930316 3259 23734946
SGTC_1446 4239-0190 62 µM -0.429074337405045 0.298455469420921 no 2366 0.333934563635813 3148 1340085
SGTC_2044 5102272 200 µM -0.429594421943755 0.298251086608036 no 2367 0.333745347710367 3252 592666
SGTC_3221 9128209 49.47 µM -0.431076437997079 0.297669033830074 no 2368 0.333206396127547 3176 16460723
SGTC_2231 micatex 6.853 µM -0.431421318271548 0.29753365858453 no 2369 0.333081025923637 3229 20737 An antifungal of unknown mechanism.
SGTC_3293 9120939 62.045 µM -0.432301883699417 0.297188139358235 no 2370 0.332761009137173 3279 934087
SGTC_3350 9150499 3.57 µM -0.432524168464017 0.297100947516274 no 2371 0.332680245224868 3126 4910996 YPR165W RHO1
SGTC_2331 7980721 200 µM -0.432766001599497 0.297006101056816 no 2372 0.332592387517371 3190 2981221
SGTC_1048 3161-0300 24.5 µM -0.432777761079506 0.297001489366015 no 2373 0.332588115545826 3232 2165101
SGTC_1295 1013-0063 9.78 µM -0.43340400334477 0.296755944573088 no 2374 0.332360646333491 3291 6826038
SGTC_154 3389-1638 511.116 µM -0.433619761711495 0.296671368902112 no 2375 0.332282290979715 3218 5238686
SGTC_2826 7992541 19.48 µM -0.43386715551695 0.29657440596251 no 2376 0.332192455841597 3213 2985066
SGTC_2473 5854593 8.94 µM -0.434521167673105 0.296318143942156 no 2377 0.331955013432507 3095 2872951
SGTC_1136 pergolide 1.05886 µM -0.434762097559508 0.296223765821765 no 2378 0.331867559623772 3123 47811 A dopamine receptor agonist.
SGTC_857 0438-0306 1.35 µM -0.436055229681963 0.295717450157492 no 2379 0.331398329360429 3267 4686136
SGTC_1404 3909-7820 48.3 µM -0.436565147094715 0.295517905407667 no 2380 0.331213371698472 3263 23741373
SGTC_1068 loratadine 26.9 µM -0.43683456219071 0.295412500854527 no 2381 0.331115665853707 3203 3957 A H1 histamine antagonist.
SGTC_2071 5230951 39.92 µM -0.437983525361194 0.294963180785799 no 2382 0.330699113017866 3291 1799272
SGTC_711 k292-0785 179 µM -0.438420091905399 0.294792537183891 no 2383 0.330540892164837 3165 4146315
SGTC_3041 9091929 49.47 µM -0.438481692894771 0.294768462469566 no 2384 0.330518569114193 3349 25236887
SGTC_484 loperamide 105 µM -0.439228257658025 0.294476764358338 no 2385 0.330248075910642 3188 3955 An opioid-receptor agonist.
SGTC_1786 berberine 21.6 µM -0.440850655688878 0.293843320098844 no 2386 0.329660559242856 3227 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_455 paf C-16 10 µM -0.442199907165648 0.293317002928808 no 2387 0.329172276624269 3171 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_3233 9132340 49.47 µM -0.442517325754304 0.293193247524266 no 2388 0.329057447831283 3186 17682950
SGTC_3094 9117742 49.47 µM -0.443181957338442 0.292934198894713 no 2389 0.328817064123805 3140 17149698
SGTC_683 panaxydol 45 µM -0.444992666590559 0.29222899131342 no 2390 0.32816252688107 3223 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2320 7373003 200 µM -0.445052854337684 0.292205563871128 no 2391 0.328140779189146 3243 5415828
SGTC_1074 carmofur 3.8 µM -0.448251681041102 0.290961713782587 no 2392 0.326985784103893 3215 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2678 equilin 100 µM -0.448756600271886 0.290765604403894 no 2393 0.326803624735641 3303 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2912 7964298 10.93 µM -0.449368152662692 0.290528161766197 no 2394 0.326583050662139 3273 2975850
SGTC_2097 5376186 200 µM -0.451177480482123 0.289826200175365 no 2395 0.325930819372208 3291 742755
SGTC_680 0417-1641 114 µM -0.451313501364511 0.28977346057443 no 2396 0.325881807692036 3145 2835990
SGTC_929 2805-0021 398 µM -0.453743550311698 0.288832013390587 no 2397 0.325006708784816 3278 3098024
SGTC_945 3381-0768 11.3 µM -0.454318380871241 0.288609523847604 no 2398 0.32479984413468 3341 1126236 YIL048W NEO1
SGTC_2914 7968218 45.32 µM -0.456851255756105 0.287630131457313 no 2399 0.323888980911884 3265 2977111
SGTC_2988 9073640 71.4286 µM -0.457187641781084 0.287500178578648 no 2400 0.323768090136016 3382 9102229
SGTC_1777 st045864 34.765 µM -0.457198667457524 0.28749591960175 no 2401 0.323764128031011 3287 4691462
SGTC_3279 9140807 49.47 µM -0.457727131352943 0.287291820586113 no 2402 0.323574246606996 3256 45595718
SGTC_1698 5-fluorocytosine 1.055 µM -0.459053670274924 0.286779797824666 no 2403 0.323097812682949 3319 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_544 k015-0020 52.4 µM -0.459959705879038 0.286430331403649 no 2404 0.322772571553165 3253 3008304
SGTC_417 st075190 100 µM -0.462157974290236 0.285583279736056 no 2405 0.321984019101625 3345 222757
SGTC_416 estradiol valerate 100 µM -0.462232226887561 0.285554689049534 no 2406 0.321957397524182 3287 13791 A steroid.
SGTC_594 1487-1584 10.8 µM -0.462908669017827 0.285294290282242 no 2407 0.321714916697201 3207 5013332
SGTC_2956 9076196 2.52 µM -0.462935576888927 0.285283934342887 no 2408 0.321705272736643 3349 16423868
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.46387975805747 0.284920664042875 no 2409 0.321366948008625 3160 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1995 st072814 61.1 µM -0.464201037759699 0.284797103168486 no 2410 0.321251858885927 3216 5769371
SGTC_1596 piperlongumine 63 µM -0.465123949958619 0.284442302909599 no 2411 0.320921347890904 3350 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.465224184241499 0.284403782004212 no 2412 0.320885460777076 3318 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_3019 9081971 49.47 µM -0.46550646372561 0.284295312943392 no 2413 0.320784404588937 3387 16451803
SGTC_1545 lovastatin 49.4 µM -0.466156056213471 0.284045774874907 no 2414 0.320551900619862 3290 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_3171 9103192 49.47 µM -0.466350220492262 0.283971207875136 no 2415 0.320482418457033 3346 13018434
SGTC_614 0462-0418 107 µM -0.4673256102622 0.28359676021847 no 2416 0.320133468064162 3234 5188303
SGTC_2029 5175081 200 µM -0.467599712158606 0.283491576352979 no 2417 0.320035435401415 3242 1380876
SGTC_2059 5238311 157 µM -0.467679813566525 0.283460841768292 no 2418 0.320006789469986 3174 703021
SGTC_1959 st077091 55.8 µM -0.46841056896095 0.283180527665249 no 2419 0.319745505692981 3181 821356 YKL052C ASK1
SGTC_2895 9054447 58.44 µM -0.4693313723758 0.282827501577562 no 2420 0.319416397019211 3228 2697450
SGTC_1211 1056-0033 32.3 µM -0.470238236575072 0.282480026380991 no 2421 0.319092409409778 3343 6741922
SGTC_361 000s-0510 1.45 µM -0.47058801099451 0.28234606126617 no 2422 0.31896748539882 3271 660
SGTC_140 0062-0056 502.533 µM -0.470794571504345 0.282266962055321 no 2423 0.318893720741788 3193 3758964
SGTC_165 k038-0023 64.381 µM -0.470835086957983 0.282251448528535 no 2424 0.318879253142205 3222 46368543
SGTC_3018 9082602 49.47 µM -0.471093637797596 0.282152458058956 no 2425 0.31878693413069 3344 17332089
SGTC_1799 st045822 46.1415 µM -0.471464042796172 0.282010671501849 no 2426 0.318654695699849 3345 3674992
SGTC_3123 9126162 49.47 µM -0.472030468730485 0.281793916883175 no 2427 0.31845252041881 3192 25239884
SGTC_181 1447-1644 8.07 µM -0.473248156107208 0.281328215615234 no 2428 0.318018072442615 3301 534600
SGTC_3093 9117344 49.47 µM -0.473420330750026 0.281262397875292 no 2429 0.317956663950126 3350 24824913
SGTC_1067 clotrimazole 1.36 µM -0.473651140423401 0.281174177203516 no 2430 0.317874350307188 3244 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_541 4513-1321 94 µM -0.473899046048675 0.281079436960339 no 2431 0.317785949758561 3247 747515
SGTC_43 0570-0105 72.5 µM -0.47428554148665 0.280931763652902 no 2432 0.317648150252378 3243 1114046 YDL195W SEC31
SGTC_1706 st031321 9.9705 µM -0.474509304372864 0.280846284817889 no 2433 0.317568382289572 3334 6103185
SGTC_1134 3477-0009 42.5 µM -0.474899665360123 0.280697194565658 no 2434 0.317429244990702 3425 3973534
SGTC_176 1486-1328 72.834 µM -0.474959206489239 0.280674457436358 no 2435 0.317408024870419 3297 22310231
SGTC_547 1120-0019 610 nM -0.47500215572214 0.28065805685172 no 2436 0.317392718380273 3260 3676939
SGTC_214 4373-3496 70 µM -0.476151888706904 0.280219192471227 no 2437 0.316983086182131 3368 3779166
SGTC_2906 7926292 26.41 µM -0.476545654586829 0.280068964630496 no 2438 0.316842844967036 3344 2966319
SGTC_2942 9052777 62.25 µM -0.476858443388719 0.279949658638259 no 2439 0.316731462798204 3282 6469503
SGTC_2792 7535235 81.82 µM -0.477521591665493 0.279696797734091 no 2440 0.316495374729799 3249 1281891
SGTC_264 promethazine 12.5 mM -0.479365732999652 0.278994203020692 no 2441 0.315839233381883 3390 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_44 0929-0055 61.211 µM -0.479607292476917 0.278902235515414 no 2442 0.315753329971291 3196 1379590
SGTC_1614 st002383 48.6 µM -0.479759182356037 0.278844414937831 no 2443 0.31569931996988 3336 1947235
SGTC_1719 st032227 49.2 µM -0.47992271671427 0.278782168127848 no 2444 0.315641173747827 3231 3125804
SGTC_2020 4017018 200 µM -0.480019227994798 0.278745435783705 no 2445 0.315606860370161 3332 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2336 9001819 198.65 µM -0.480087337787807 0.278719514508153 no 2446 0.315582645742591 3439 2989602
SGTC_2201 6605497 169.863 µM -0.482498504859278 0.277802627634754 no 2447 0.314725930137718 3287 670741
SGTC_954 1189-0853 2.85 µM -0.484289312035541 0.277122597509259 no 2448 0.314090280032651 3333 2828194
SGTC_1652 st011932 78 µM -0.487337501317339 0.275966973375071 no 2449 0.31300958803535 3319 1551076
SGTC_2722 naftopidil 47.16 µM -0.488024470204175 0.275706858135751 no 2450 0.312766254254977 3345 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_412 gemfibrozil 100 µM -0.489493315683256 0.275151096259676 no 2451 0.312246242845066 3343 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2264 7948757 110.76 µM -0.491682844646605 0.27432367731201 no 2452 0.311471783863428 3184 2971411
SGTC_2388 9080168 200 µM -0.492133484164177 0.274153534029625 no 2453 0.31131249132703 3244 15943073
SGTC_1917 st066507 28.5 µM -0.492152107681483 0.274146503663426 no 2454 0.311305909026201 3221 3156428
SGTC_2472 5377652 49.4 µM -0.493283016301966 0.273719753344315 no 2455 0.310906313517982 3302 1610903
SGTC_3219 9131112 49.47 µM -0.494729229282108 0.273174501606146 no 2456 0.310395633065351 3342 17612988 YMR079W SEC14
SGTC_400 oxethazaine 37.5 µM -0.494808431124683 0.273144656449905 no 2457 0.310367676196277 3329 4621 A local anesthetic.
SGTC_1091 telmisartan 47.6 µM -0.495693402436112 0.272811287942719 no 2458 0.310055371302308 3386 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_723 4182-0001 115 µM -0.495752402456101 0.272789069826152 no 2459 0.310034555162223 3277 744821 YLR208W SEC13
SGTC_875 0709-0210 25.7 µM -0.495890588909899 0.272737035344901 no 2460 0.309985803179098 3384 6251364
SGTC_645 0845-0943 5.41 µM -0.496662900552768 0.272446310025685 no 2461 0.309713394265712 3305 1885106
SGTC_3307 9126885 69.2785 µM -0.49759454844954 0.272095809856604 no 2462 0.309384923478765 3243 24824909
SGTC_3184 9108758 49.47 µM -0.498078436159368 0.271913852407885 no 2463 0.309214379407087 3309 902885
SGTC_831 k061-1017 217 µM -0.500275870290884 0.271088308362362 no 2464 0.308440421061238 3345 1240153
SGTC_789 1309-1135 70.6 µM -0.500412026298085 0.271037197686162 no 2465 0.308392493497945 3367 3092424
SGTC_2972 9093619 59.92 µM -0.502157757674821 0.270382305689143 no 2466 0.307778277303646 3223 25236256
SGTC_126 0417-1624 672.48 µM -0.502833146668822 0.27012915326151 no 2467 0.307540793500195 3442 41912 YDL195W SEC31
SGTC_956 1185-0240 191 µM -0.502957507690066 0.270082552616793 no 2468 0.307497073817377 3272 1416193
SGTC_879 0831-1030 162 µM -0.503443178516755 0.269900600253389 no 2469 0.307326360225687 3374 1549252
SGTC_273 hydroxyurea 18.1 mM -0.503882168635431 0.269736189225646 no 2470 0.307172090841761 3287 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_506 n9-isopropylolomoucine 153 µM -0.504486402878775 0.269509972861775 no 2471 0.306959807372368 3398 6610355
SGTC_1079 idarubicin 2.36 µM -0.505215360224785 0.269237188617732 no 2472 0.306703791494873 3373 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_175 3793-3120 23.7 µM -0.505941635344074 0.268965545888004 no 2473 0.30644881138619 3263 5322297
SGTC_1689 st020265 53.493 µM -0.506126393695624 0.268896464194933 no 2474 0.306383961508986 3401 5758320 YPR016C TIF6
SGTC_531 3788-1495 174 µM -0.50616575132022 0.268881749414047 no 2475 0.306370147830954 3236 2896655
SGTC_151 3013-0144 2.285 µM -0.506680370745307 0.268689383959143 no 2476 0.306189552832366 3383 906558 YHR107C CDC12
SGTC_841 0251-0215 91.2 µM -0.509790175326673 0.267528408099704 no 2477 0.305099234708747 3351 3888614
SGTC_3280 9140961 49.47 µM -0.512065246613737 0.266680666250718 no 2478 0.30430267315203 3264 4901226
SGTC_1177 0983-0204 23.6 µM -0.512230321176031 0.266619208702548 no 2479 0.30424491231106 3406 766818
SGTC_1985 st071382 65.5 µM -0.512915836236727 0.266364066887184 no 2480 0.304005097659216 3384 6123237
SGTC_346 4513-0042 7.16 µM -0.513163816258661 0.266271801654182 no 2481 0.303918367236427 3325 2827372
SGTC_480 am 92016 50 µM -0.513239587008995 0.266243613069881 no 2482 0.303891868797787 3345 2129 K+ channel blocker.
SGTC_2721 ifenprodil 61.44 µM -0.515222223611928 0.265506560731669 no 2483 0.30319887053676 3421 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_3198 9112019 49.47 µM -0.516054102880102 0.265197615170759 no 2484 0.302908311317656 3381 45595555
SGTC_36 0335-0881 14.2 µM -0.516600040188033 0.264994962760779 no 2485 0.302717693821187 3343 23828853
SGTC_8 0354-0001 70 µM -0.518035967492194 0.264462321182743 no 2486 0.302216587363046 3389 4993152
SGTC_2439 5492030 7.2 µM -0.518238803925111 0.26438712516107 no 2487 0.30214583200998 3369 5722370
SGTC_3049 9092223 49.47 µM -0.519414548739587 0.263951464636981 no 2488 0.301735843975498 3376 8623917
SGTC_699 0375-0592 111 µM -0.51976341292907 0.263822266915659 no 2489 0.301614241440884 3431 762578
SGTC_971 1315-0384 26.7 µM -0.523221326466898 0.262543415711467 no 2490 0.300410121041141 3336 6769120
SGTC_2862 9027634 71.43 µM -0.523753964779025 0.262346710768893 no 2491 0.300224838037504 3262 5012562
SGTC_1550 gossypolone 36.6 µM -0.525065712005683 0.261862600572275 no 2492 0.299768755469253 3369 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_137 0438-0332 85.389 µM -0.525297311465187 0.261777174658382 no 2493 0.299688263045349 3434 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_800 3448-7362 155 µM -0.526697318231993 0.261261084005332 no 2494 0.299201899116174 3447 15991913
SGTC_423 5-fluorouracil 457 µM -0.527394805875135 0.261004161299304 no 2495 0.298959724874497 3254 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_70 0141-0289 43.283 µM -0.527930722366405 0.260806842343541 no 2496 0.298773710154397 3337 352408
SGTC_1735 st034310 56.75 µM -0.528136243824741 0.260731191814359 no 2497 0.298702388339886 3443 871153
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.529855447582892 0.260098811554117 no 2498 0.2981060789714 3427 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_955 1216-0110 33 µM -0.533004375806236 0.258942585064986 no 2499 0.297015275621337 3383 3619719
SGTC_3250 9135583 49.47 µM -0.534554663723367 0.258374327114216 no 2500 0.296478920193483 3438 7699353
SGTC_1325 1431-0015 227 µM -0.534823015110863 0.258276028572312 no 2501 0.296386123347103 3314 1103340
SGTC_2924 9010168 62.78 µM -0.535262330250771 0.258115146946563 no 2502 0.296234235387016 3408 2993929
SGTC_3220 9131269 49.47 µM -0.536249553562462 0.257753805515553 no 2503 0.295893045051573 3453 17722206
SGTC_401 neomycin 50 µM -0.53641482598399 0.257693338514656 no 2504 0.295835943544546 3381 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1681 tripelennamine 100 µM -0.537858300853347 0.257165538227766 no 2505 0.295337439276782 3431 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2880 9042983 58.44 µM -0.53876463426236 0.256834428860921 no 2506 0.295024634567471 3446 6464714
SGTC_2855 9016525 58.44 µM -0.539806206595134 0.256454187057178 no 2507 0.294665343166445 3405 43811474
SGTC_1848 st056003 16.4 µM -0.540688264820292 0.256132407819382 no 2508 0.294361234231838 3466 146492
SGTC_1684 st024538 14.6195 µM -0.540984381284439 0.256024430283709 no 2509 0.294259174082697 3359 6732859
SGTC_1564 D-Arginine 115 µM -0.544374711871871 0.254789855894549 no 2510 0.293091821985927 3364 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2356 9061756 188.97 µM -0.548265507250068 0.25337688948463 no 2511 0.291754803937306 3380 20104043
SGTC_2938 9059746 27.26 µM -0.548552887677352 0.25327268908701 no 2512 0.291656162442876 3397 6471769
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.5493319255218 0.252990333478889 no 2513 0.291388840906022 3405 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1454 4239-0054 42.6 µM -0.550156999428358 0.252691473197187 no 2514 0.291105847123923 3542 1340767
SGTC_2360 9040895 200 µM -0.55050289033771 0.252566239082598 no 2515 0.290987247493113 3375 4914414
SGTC_1378 2093-0007 380 nM -0.550580596675236 0.252538109033348 no 2516 0.290960606525175 3416 3618014
SGTC_926 2268-1401 59.4 µM -0.550864993988704 0.252435169984128 no 2517 0.290863113004872 3445 2931578
SGTC_1017 4239-0030 168 µM -0.551320791871803 0.252270237762244 no 2518 0.290706893946141 3359 1149593
SGTC_1197 1601-0112 267 µM -0.552791974615657 0.251738272523643 no 2519 0.29020293227146 3365 7350313
SGTC_1773 st048542 73.5835 µM -0.553152927600118 0.251607846021666 no 2520 0.290079348416884 3333 3237138
SGTC_1911 st060208 74.3 µM -0.553552786471322 0.251463402979018 no 2521 0.289942472687028 3434 688783
SGTC_2686 alizarin 95.37 µM -0.554002455949343 0.251301018963352 no 2522 0.289788582472781 3370 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_707 0865-0008 204 µM -0.554462251787902 0.251135035475116 no 2523 0.289631266354788 3411 723043
SGTC_664 1222-0054 14.9 µM -0.554915698280615 0.250971400873558 no 2524 0.289476161897714 3447 6813991
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.556202264320516 0.250507426916196 no 2525 0.289036295740863 3418 2333 A French combination drug.
SGTC_2765 myclobutanil 7.74 µM -0.556903767143296 0.250254635751387 no 2526 0.288796590322384 3461 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_850 0388-0143 75.9 µM -0.557516963100763 0.250033777393152 no 2527 0.288587136286755 3368 67273
SGTC_2267 7931562 200 µM -0.558045161762335 0.249843615947269 no 2528 0.288406772821222 3294 934880
SGTC_116 0155-0182 31.788 µM -0.558214584762758 0.24978263674962 no 2529 0.288348931377562 3392 771486
SGTC_1859 st055998 20 µM -0.559167193827075 0.249439918225469 no 2530 0.288023810095088 3510 676301
SGTC_1634 st006576 41 µM -0.559552853304004 0.249301241280049 no 2531 0.287892235435958 3492 3915356
SGTC_950 1165-0508 94.1 µM -0.560690759433846 0.248892307549819 no 2532 0.287504183830277 3415 6148369
SGTC_460 trequinsin 123 µM -0.561920531424002 0.248450761385785 no 2533 0.287085082190657 3484 5537 A vasodilator.
SGTC_628 1636-0253 16 µM -0.562323475758196 0.248306176210805 no 2534 0.286947823237249 3423 4456143
SGTC_1534 6-azauridine 81.6 µM -0.563255120230694 0.247972053781535 no 2535 0.286630586969703 3419 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_643 k048-0106 28.4 µM -0.563691350228121 0.247815687955523 no 2536 0.286482102549354 3473 6763920
SGTC_1506 4226-2149 212 µM -0.563870685314901 0.247751420900736 no 2537 0.286421070874036 3443 991114
SGTC_590 k048-0076 22.4 µM -0.564661796791099 0.247468022090628 no 2538 0.286151911911952 3467 6832814
SGTC_2966 9084041 48.03 µM -0.565241318155212 0.247260530903553 no 2539 0.285954818289902 3254 17741380
SGTC_337 1315-0038 354 µM -0.566010633696567 0.246985229786115 no 2540 0.285693275921796 3416 1626437
SGTC_2343 7990716 14.84 µM -0.566889439359831 0.246670948206377 no 2541 0.285394649786374 3412 6456862
SGTC_1978 st071761 42 µM -0.567319652918068 0.246517171838886 no 2542 0.285248513535615 3386 5147680
SGTC_1355 1499-0035 1.68 µM -0.567745818546055 0.246364893024791 no 2543 0.285103787459228 3449 1548538
SGTC_638 3970-0837 4.09 µM -0.567809022374667 0.246342313132172 no 2544 0.285082326386019 3416 4118451 YLR208W SEC13
SGTC_2800 7887935 81.82 µM -0.567960259213639 0.246288287497392 no 2545 0.285030976533639 3466 2961002
SGTC_26 0302-0163 425.158 µM -0.568171832029687 0.246212718981191 no 2546 0.284959148045178 3426 3100915
SGTC_575 k072-0246 11.9 µM -0.568962887165615 0.245930284060614 no 2547 0.284690663138905 3465 6796779
SGTC_967 1306-0166 352 µM -0.570503544241684 0.24538071390598 no 2548 0.28416810946244 3481 4437607
SGTC_91 0417-1751 58.384 µM -0.570887761138066 0.245243762202684 no 2549 0.284037863858893 3522 6795624
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.570898034891275 0.245240100751975 no 2550 0.284034381553557 3587 16725076
SGTC_146 3448-8650 53.125 µM -0.571780803664603 0.244925601621881 no 2551 0.28373524194569 3442 2891488 YIL048W NEO1
SGTC_1612 st002233 45.4 µM -0.573531153452697 0.244302656534271 no 2552 0.283142555872094 3493 1035021
SGTC_2940 9060638 45.86 µM -0.57403066684465 0.244125037737225 no 2553 0.282973524623316 3446 4027022
SGTC_846 0335-0850 148 µM -0.57538324559424 0.243644432634628 no 2554 0.282516066380869 3474 6819598
SGTC_1025 k007-0731 70 µM -0.575532152565434 0.24359155349538 no 2555 0.282465726005768 3372 6256118
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.576262743480704 0.243332199333282 no 2556 0.282218800623161 3456 65057 A dermal irritant. YDR527W RBA50
SGTC_2414 st077232 92.9 µM -0.57651774648937 0.243241710370916 no 2557 0.282132639079276 3315 729801
SGTC_3109 9122853 49.47 µM -0.576736093142652 0.243164243539054 no 2558 0.282058873212438 3455 1234709
SGTC_1056 3448-1962 115 µM -0.577574494881513 0.242866912419913 no 2559 0.281775715305197 3459 715507
SGTC_3316 9136639 10.545 µM -0.578177860201579 0.242653056500955 no 2560 0.281572022323347 3485 4903665
SGTC_2199 6590217 200 µM -0.578326290945297 0.242600462556044 no 2561 0.281521923766014 3412 703109
SGTC_1193 1488-0126 41.5 µM -0.579354243238068 0.242236394362755 no 2562 0.281175085892576 3488 1384710
SGTC_1645 Cervolide 78 µM -0.580970087147679 0.241664712674427 no 2563 0.280630307022422 3452 23173 A fragrance.
SGTC_1518 st038567 90.8 µM -0.58143877826722 0.241499028021557 no 2564 0.280472384251454 3502 77966
SGTC_2814 7977482 42.97 µM -0.582144890921165 0.241249530198496 no 2565 0.280234544918304 3527 6456762
SGTC_3172 9105863 49.47 µM -0.583037650142671 0.240934283308719 no 2566 0.279933977504874 3462 2348785
SGTC_2323 6148992 148.28 µM -0.584632575945792 0.240371648845864 no 2567 0.279397399378902 3410 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1831 st055328 12 µM -0.584770147681102 0.240323151865372 no 2568 0.279351139773931 3504 1103068
SGTC_84 0443-0269 128.823 µM -0.584909775945322 0.240273935365853 no 2569 0.279304192449735 3466 6150058
SGTC_1820 st053765 18.6 µM -0.585986482388956 0.239894599865443 no 2570 0.278942299390939 3479 3690829
SGTC_1567 st069303 68.4 µM -0.586323317968092 0.239775996106378 no 2571 0.278829132052353 3505 5581319
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.587657722939799 0.239306451038513 no 2572 0.278381028997098 3488 442882
SGTC_2405 ticlatone 3.52 µM -0.588259838084906 0.239094745752517 no 2573 0.278178949253239 3325 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1469 k284-2957 126 µM -0.588414067858914 0.239040534627661 no 2574 0.278127198716158 3478 23884841
SGTC_379 3970-0972 5.9 µM -0.58947114979157 0.238669155636019 no 2575 0.277772629975711 3468 2898042 YBL034C STU1
SGTC_2344 7990960 76.95 µM -0.590858460705097 0.238182238510318 no 2576 0.277307630292811 3442 140813
SGTC_2214 7179297 48.276 µM -0.591074850118941 0.238106339449225 no 2577 0.277235135096782 3509 769744
SGTC_2636 apigenin dimethyl ether 100 µM -0.591111888710371 0.238093349410762 no 2578 0.277222727286177 3529 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1075 aripiprazole 15.2 µM -0.592026497328848 0.237772704480147 no 2579 0.276916422504909 3491 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3067 9117431 49.47 µM -0.592215601766528 0.237706437509438 no 2580 0.276853111622021 3445 17150885
SGTC_3057 9095946 49.47 µM -0.593553618056474 0.237237852392534 no 2581 0.276405355482159 3493 24540043
SGTC_1108 betulinic acid 729.144 nM -0.595689781537761 0.236490801855482 no 2582 0.275691242924077 3480 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1174 0739-0097 51.1 µM -0.59692780978571 0.236058436873538 no 2583 0.275277789609033 3488 728447
SGTC_2194 5927483 104.545 µM -0.597104619697901 0.235996723913012 no 2584 0.275218766886427 3515 760979
SGTC_3102 9121669 49.47 µM -0.597617653727949 0.235817707088626 no 2585 0.275047541031468 3461 41905072
SGTC_3100 9120536 49.47 µM -0.598371154030431 0.235554918339034 no 2586 0.274796154375071 3441 16421196
SGTC_1468 k284-1086 134 µM -0.599055436019467 0.235316410032038 no 2587 0.274567958868429 3543 15996457
SGTC_1381 2324-0066 62.1 µM -0.599464034724601 0.235174055461713 no 2588 0.274431743277166 3498 10885928
SGTC_2061 5245884 80.95 µM -0.599522799608242 0.235153585863975 no 2589 0.274412155421846 3490 573863
SGTC_1147 3809-1045 12.3 µM -0.599882947515386 0.235028156881996 no 2590 0.274292123887401 3462 325925
SGTC_2484 5809818 12.04 µM -0.599976539022053 0.234995567749266 no 2591 0.274260935580157 3488 2870548
SGTC_1005 4092-0690 4.4 µM -0.600333841081466 0.234871175958322 no 2592 0.274141884830947 3457 1529343
SGTC_942 3253-1115 227 µM -0.600335373825526 0.23487064242441 no 2593 0.274141374185474 3556 46497897
SGTC_2597 laccaic acid a 100 µM -0.600373358486502 0.23485742053218 no 2594 0.274128719453631 3482 5491415 A textile dye.
SGTC_2735 sertaconazole 140 nM -0.600531610627792 0.234802339756741 no 2595 0.27407600026684 3544 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_55 0767-0285 6.563 µM -0.600920506262049 0.234667012225416 no 2596 0.273946467149689 3503 3116166
SGTC_1298 1079-1278 263 µM -0.601380951132981 0.234506842836332 no 2597 0.273793141591096 3521 2840950
SGTC_1791 st048313 56.1 µM -0.601838892743333 0.234347604229435 no 2598 0.273640691709036 3487 1204976
SGTC_3206 9114350 49.47 µM -0.602187740098068 0.234226340794666 no 2599 0.273524587760892 3486 17087243
SGTC_1187 1391-0724 117 µM -0.602523575778757 0.234109633196239 no 2600 0.273412837419411 3530 6997986
SGTC_1222 0366-0074 1.18 µM -0.602563820567284 0.234095649730133 no 2601 0.273399447360886 3552 286520
SGTC_2319 6033012 152.6 µM -0.60371423181955 0.233696123146131 no 2602 0.273016825245835 3428 847246
SGTC_1237 0330-0133 46.1 µM -0.60422048308435 0.233520426875028 no 2603 0.272848532282114 3481 X1237 YHR072W ERG7
SGTC_2984 9022109 38.96 µM -0.604442264929906 0.233443479793543 no 2604 0.272774821618239 3590 6459207
SGTC_1170 0310-0127 64.8 µM -0.605467029287528 0.233088121099634 no 2605 0.27243436274098 3475 774975
SGTC_937 3122-0005 46.7 µM -0.60583344839935 0.232961130465901 no 2606 0.272312678055976 3530 759535
SGTC_2809 7964133 12.99 µM -0.608880312269107 0.23190666211577 no 2607 0.271301887397451 3494 1253665
SGTC_2164 5685496 200 µM -0.609416643443076 0.231721322439786 no 2608 0.271124154409322 3544 759046
SGTC_1739 st037196 92.5 µM -0.609831229909197 0.23157811059291 no 2609 0.270986805791891 3551 612214
SGTC_2346 9031566 143.75 µM -0.610137799873998 0.231472242946839 no 2610 0.270885264360158 3462 4771086
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.610608728258574 0.231309670068414 no 2611 0.270729321488481 3462 390807
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.61103288107408 0.231163299480556 no 2612 0.270588906219569 3560 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2499 avocadenofuran 51.48 µM -0.612710003963949 0.230585048835435 no 2613 0.270034053282091 3425 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3334 9142812 21.919 µM -0.612752057168061 0.230570559821071 no 2614 0.270020147880198 3542 45283678
SGTC_893 0958-0369 48.9 µM -0.613432929909101 0.230336042688256 no 2615 0.26979505892739 3531 6819948
SGTC_467 ro 31-8220 72.8 µM -0.614721146610238 0.229892699506097 no 2616 0.269369446023013 3468 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1080 nisoldipine 24.4 µM -0.617068392961331 0.229086117984942 no 2617 0.2685948076576 3497 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2576 guaiol 23.12 µM -0.61767798583157 0.228876904259821 no 2618 0.268393813078464 3522 227829
SGTC_993 3909-8757 62.7 µM -0.619269732396006 0.228331118933602 no 2619 0.267869340258867 3496 4288324 YLR208W SEC13
SGTC_3268 9137683 49.47 µM -0.619487293602011 0.228256577416741 no 2620 0.267797695012115 3549 1953228
SGTC_2720 fluspirilene 36.88 µM -0.620823410322723 0.227799092914319 no 2621 0.267357909204805 3526 3396 An atypical antipsychotic.
SGTC_1092 toremifene 6.32 µM -0.621445035945199 0.227586425177635 no 2622 0.267153424002247 3561 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2108 5365811 200 µM -0.622366033001992 0.227271543457585 no 2623 0.266850605071435 3550 780283
SGTC_2974 9094440 9.66 µM -0.622971722983536 0.227064596658508 no 2624 0.266651552002909 3580 25236134
SGTC_740 k014-0057 261 µM -0.623070546125341 0.227030841725231 no 2625 0.266619082034746 3525 4012779
SGTC_1981 st071826 47 µM -0.62314936770983 0.227003920734704 no 2626 0.266593185340335 3515 11838600
SGTC_1958 st076513 41.9 µM -0.623532015787965 0.226873255400142 no 2627 0.26646748505761 3483 732122 YGL099W LSG1
SGTC_3345 9148410 3.559 µM -0.625752272694662 0.226115927606393 no 2628 0.265738720561461 3537 4903596
SGTC_581 0958-0271 211 µM -0.626762340909252 0.225771867571817 no 2629 0.265407516236611 3535 4591145
SGTC_317 4495-0002 170 µM -0.627006371919645 0.22568878760436 no 2630 0.265327529184247 3529 15991618
SGTC_1759 st043059 70 µM -0.627639611529337 0.225473282884854 no 2631 0.265120026708787 3499 669426
SGTC_1597 7-benzyloxygramine 47.5 µM -0.629084483412278 0.22498199904962 no 2632 0.264646874128153 3545 260807
SGTC_1334 1486-0610 236 µM -0.630998341592345 0.224332185984102 no 2633 0.264020804396575 3566 3742339
SGTC_2881 9058953 51.95 µM -0.632343038046275 0.223876258626049 no 2634 0.26358137323624 3526 17122249
SGTC_2115 tiliquinol 12.7705 µM -0.633295030647421 0.22355379848348 no 2635 0.2632704989078 3525 71208 A bioactive hydroxyquinoline.
SGTC_1865 st057639 52.2 µM -0.633495540988711 0.223485915060574 no 2636 0.26320504589688 3575 688818
SGTC_2109 5483026 200 µM -0.634405779604697 0.223177898322551 no 2637 0.262908019353395 3587 759335
SGTC_138 0850-0259 40.9225 µM -0.635269714662211 0.222885773979559 no 2638 0.262626261065941 3610 6813004
SGTC_1509 1326-1131 80 µM -0.635682708051736 0.222746204570753 no 2639 0.262491624634942 3516 768313
SGTC_794 k038-0031 316 µM -0.636345549211246 0.222522304294324 no 2640 0.262275611362335 3617 6624242
SGTC_1940 st075990 51.1 µM -0.63828858814951 0.221866707618579 no 2641 0.261642919610368 3673 1084979
SGTC_3037 9091026 49.47 µM -0.63841554232373 0.221823910706086 no 2642 0.261601608107738 3590 25236398 YIL048W NEO1
SGTC_1372 2752-0194 270 µM -0.638847220582186 0.221678425000717 no 2643 0.261461162963483 3554 823334
SGTC_232 clozapine 119 µM -0.639425795543156 0.221483517193798 no 2644 0.261272986184081 3553 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_604 1000-0114 314 µM -0.640076332558948 0.221264484172126 no 2645 0.26106148746453 3617 1572745
SGTC_668 1682-0499 62.6 µM -0.643656192517784 0.220061379743202 no 2646 0.259899201546106 3587 682214
SGTC_1953 st076800 12.1 µM -0.644122270262795 0.219905018846217 no 2647 0.259748075044459 3528 297591
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.64436491680181 0.219823640437873 no 2648 0.259669414446096 3568 2374 Ca(2+)-ATPase inhibitor.
SGTC_1905 st060207 84.5 µM -0.644486564090527 0.219782849070799 no 2649 0.259629983735069 3522 1948547
SGTC_2365 9042475 200 µM -0.644712038972879 0.219707253216562 no 2650 0.259556906558055 3580 6464479
SGTC_3229 9132204 49.47 µM -0.644865489223598 0.219655813883546 no 2651 0.259507178883709 3578 17682924
SGTC_2712 st079126 47.7 µM -0.645521369353307 0.219436028823128 no 2652 0.259294687334557 3561 3152970
SGTC_1086 cerivastatin 2.18 µM -0.647016678091978 0.218935424378338 no 2653 0.25881057471451 3566 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1060 3448-7350 82 µM -0.647761258601571 0.218686396438024 no 2654 0.258569688134432 3563 570178
SGTC_1672 st016598 6.51 µM -0.651445514445696 0.217456584025693 no 2655 0.257379469015952 3541 4665860 YNL267W PIK1
SGTC_166 k072-0058 166.424 µM -0.651824272457991 0.217330380521458 no 2656 0.257257270737663 3617 5846229
SGTC_2239 6685329 187.64 µM -0.65442298604393 0.216465621400168 no 2657 0.25641966467738 3610 805680
SGTC_1896 st058441 89 µM -0.654511377980611 0.216436242776096 no 2658 0.256391199583175 3551 688759
SGTC_1726 st035556 14.5795 µM -0.654522101985407 0.216432678620327 no 2659 0.256387746214946 3644 5919439
SGTC_1196 1588-0294 184 µM -0.656279624806 0.215849019623877 no 2660 0.255822112424306 3588 6144269
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.65636653429974 0.21582018137767 no 2661 0.255794158747242 3548 279621
SGTC_62 0180-0423 3.232 µM -0.65694466779 0.215628402377264 no 2662 0.255608247765996 3579 30102 YGL099W LSG1
SGTC_631 k072-0230 41.5 µM -0.657536056491308 0.215432328620952 no 2663 0.255418147335523 3608 5773147
SGTC_869 0564-0080 44.1 µM -0.658496029031356 0.215114271928708 no 2664 0.255109723918746 3575 6843321
SGTC_1049 3226-0134 66 µM -0.658757593888461 0.215027657925484 no 2665 0.255025721205483 3639 5702385
SGTC_1002 4049-0206 172 µM -0.663156232280042 0.213574139054526 no 2666 0.253615249729101 3645 4662749
SGTC_2054 5233173 129 µM -0.663282338122242 0.213532552293771 no 2667 0.253574873019323 3613 6889
SGTC_674 0498-0004 451 µM -0.663438401634901 0.213481092727185 no 2668 0.253524909104922 3579 4231473
SGTC_3030 9087619 49.47 µM -0.663606609525906 0.213425636830722 no 2669 0.253471062946138 3585 25236973
SGTC_1375 2910-0797 186 µM -0.664336192587651 0.21318520024891 no 2670 0.253237580787365 3604 742508
SGTC_2513 baicalein 25.65 µM -0.666216619943064 0.212566227787996 no 2671 0.252636325639691 3580 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1191 1487-1166 10.6 µM -0.667175751169525 0.212250919208839 no 2672 0.25232993911854 3674 3955771
SGTC_290 2043-6722 48.1 µM -0.667362115163146 0.212189684910657 no 2673 0.252270429421917 3619 773758 YLR208W SEC13
SGTC_256 clotrimazole 625 nM -0.668592337625923 0.211785725397218 no 2674 0.25187778087055 3610 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_756 0508-1999 28.3 µM -0.668689293882037 0.211753907693925 no 2675 0.251846849184246 3602 6753853
SGTC_2718 lomofungin 53.02 µM -0.668917577227348 0.211679004011615 no 2676 0.251774028499362 3653 5351222 A RNA synthesis inhibitor.
SGTC_2655 perillic acid 100 µM -0.67048372933949 0.211165540938922 no 2677 0.251274737578328 3610 5702197 An apoptosis inducer.
SGTC_588 3970-1144 52.9 µM -0.670496746964668 0.211161276170386 no 2678 0.251270589740849 3562 1888707
SGTC_1153 4055-0057 267 µM -0.670706357637516 0.211092611531732 no 2679 0.251203805968906 3627 882706
SGTC_2697 mebhydrolin 72.4 µM -0.671737822105983 0.210754913253334 no 2680 0.250875309272615 3635 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2531 methyl deoxycholate 70.07 µM -0.672572656078701 0.210481823367705 no 2681 0.250609601265518 3608 16667744 Haematoxylin.
SGTC_1769 st044406 64.4 µM -0.673334348672819 0.210232840695295 no 2682 0.250367302556473 3630 670903
SGTC_1761 st044296 37 µM -0.674490759476595 0.209855163056876 no 2683 0.249999679274407 3642 1826700
SGTC_424 splitomicin 100 mM -0.674525564236916 0.20984380219239 no 2684 0.24998861927431 3606 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2236 dapsone 200 µM -0.674736886473709 0.209774830789545 no 2685 0.249921472426606 3654 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1151 3909-8316 15.3 µM -0.675371426035212 0.209567809722926 no 2686 0.249719907401089 3653 800431
SGTC_2818 7996756 12.99 µM -0.676828385521576 0.209092925850151 no 2687 0.249257422977764 3639 2241621
SGTC_1671 st016596 74.5 µM -0.678268995533646 0.208623994565055 no 2688 0.248800576578221 3677 2829167
SGTC_2813 7971799 71.43 µM -0.678577734954669 0.208523577884487 no 2689 0.248702727139584 3665 2234054
SGTC_2985 9022375 71.43 µM -0.678672338993812 0.208492813876017 no 2690 0.248672748183597 3673 4939335
SGTC_1772 st048439 82.2 µM -0.678699695118545 0.208483918517367 no 2691 0.248664079694092 3622 2927068 YDL195W SEC31
SGTC_3254 9136651 49.47 µM -0.678833444298843 0.208440430677022 no 2692 0.248621700154225 3637 16454030
SGTC_3191 9110352 49.47 µM -0.682900492427466 0.207120607858406 no 2693 0.247334861385962 3635 17122424
SGTC_1329 1447-1697 50.6 µM -0.683269433227944 0.207001125672453 no 2694 0.247218302671901 3631 2840515
SGTC_235 0330-0087 5 mM -0.687023897762104 0.205787556180202 no 2695 0.246033834524778 3679 46494818 YHR062C RPP1
SGTC_1267 0828-0272 9.49 µM -0.687924712889235 0.205497011572436 no 2696 0.245750096592361 3695 745334
SGTC_2674 ligustilide 100 µM -0.688182133011023 0.205414029284451 no 2697 0.245669046922552 3629 5319022 A signalling regulator.
SGTC_2505 galangin 7.89 µM -0.688429275659914 0.205334378783859 no 2698 0.24559124666124 3586 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3000 9075062 71.4286 µM -0.688431018135964 0.205333817274171 no 2699 0.24559069817849 3640 17057871
SGTC_1866 st057638 64 µM -0.688633432172579 0.205268595931869 no 2700 0.245526988375793 3650 688802
SGTC_2694 st077685 81.9 µM -0.690448183393672 0.204684401365709 no 2701 0.244956192419638 3637 2838096
SGTC_2005 4024620 188 µM -0.691117114579189 0.204469312504346 no 2702 0.244745972900051 3665 236743
SGTC_989 1501-0895 10.3 µM -0.691396972621886 0.204379366571924 no 2703 0.244658053032892 3652 2830112
SGTC_833 3852-0053 558 µM -0.692131801409178 0.204143305908043 no 2704 0.244427281081125 3704 3123681
SGTC_806 3966-4455 5.86 µM -0.693453852892377 0.203719011557234 no 2705 0.244012388170054 3622 714982
SGTC_2665 lovastatin 100 µM -0.694765719388659 0.203298506073749 no 2706 0.243601067372047 3666 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_3328 9140624 29.0385 µM -0.695572254048948 0.2030402368956 no 2707 0.24334837360073 3674 4904392
SGTC_2127 5253358 187.912 µM -0.695702988635746 0.202998391420915 no 2708 0.24330742675298 3619 20612
SGTC_1900 st060200 72.8 µM -0.696088615793323 0.2028749900372 no 2709 0.243186667735401 3670 688945
SGTC_3121 9125696 49.47 µM -0.696623250642926 0.202703980070381 no 2710 0.243019300626352 3722 1235365
SGTC_2384 9036245 200 µM -0.697183405845621 0.202524899521788 no 2711 0.242844011242779 3674 6462766
SGTC_2963 9082507 9 µM -0.698489715605595 0.202107642425089 no 2712 0.242435493657618 3682 16459611
SGTC_2008 4012253 172 µM -0.698632614124524 0.202062029492392 no 2713 0.242390828115419 3686 603940
SGTC_2266 7929956 200 µM -0.698805893272165 0.202006727386538 no 2714 0.242336672534473 3664 2967153
SGTC_335 4077-0256 27.6 µM -0.699521728501918 0.201778364330563 no 2715 0.242113019375795 3702 3121989
SGTC_448 monastrol 171 µM -0.701639110713584 0.201103790549727 no 2716 0.24145212719692 3613 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1119 parthenolide 318.541 nM -0.701927539789674 0.201012005126237 no 2717 0.241362176584737 3785 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_261 5-fluorouridine 15.376 µM -0.702104629835168 0.200955663050114 no 2718 0.241306957617188 3707 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1331 1472-0049 76.2 µM -0.70536020337354 0.19992157515934 no 2719 0.24029305176877 3653 24051409
SGTC_373 0844-0104 25.9 µM -0.707925872994162 0.199108884742142 no 2720 0.239495645798591 3727 5375804
SGTC_2282 7944268 200 µM -0.70920971523825 0.198702968636186 no 2721 0.239097172740751 3713 2970414
SGTC_2957 9076800 11.52 µM -0.710500324296507 0.198295416399657 no 2722 0.238696964952868 3654 16459615
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.710613490483813 0.198259704530238 no 2723 0.238661890489383 3671 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1471 k673-0312 37 µM -0.710910650401664 0.198165948215909 no 2724 0.238569802866869 3682 24099884
SGTC_1716 st033144 30.6155 µM -0.714980005747759 0.196884729135818 no 2725 0.237310699061394 3704 674617
SGTC_2202 7226349 200 µM -0.715636821598497 0.196678404562658 no 2726 0.237107815528298 3654 844334
SGTC_2345 9052315 157.45 µM -0.715895645232021 0.196597136670794 no 2727 0.237027893805304 3718 6469265
SGTC_202 3594-0513 34.79 µM -0.716453326854763 0.196422099677097 no 2728 0.236855738545275 3684 708429
SGTC_1920 st075728 45.7 µM -0.716784272507483 0.19631827194095 no 2729 0.23675360876264 3701 3400306
SGTC_2952 9073731 13.78 µM -0.717056073456477 0.196233024588524 no 2730 0.236669749144239 3731 16457353
SGTC_208 k072-0098 12.366 µM -0.717324647759225 0.196148811287793 no 2731 0.236586901105836 3707 5948901
SGTC_342 k048-0088 23.3 µM -0.719836788746254 0.195362174086158 no 2732 0.235812745521518 3699 6820570
SGTC_3074 9116018 49.47 µM -0.720135100512061 0.195268889946255 no 2733 0.235720908939205 3747 17027303
SGTC_2779 methotrexate 400 µM -0.72013760542747 0.19526810675659 no 2734 0.235720137873549 3761 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3158 9100007 49.47 µM -0.720609933471488 0.195120462253267 no 2735 0.235574770226383 3716 19297233
SGTC_3248 9135562 49.47 µM -0.721876431596997 0.194724904031947 no 2736 0.235185226329353 3731 17650701
SGTC_2783 7738165 71.43 µM -0.722003547852213 0.194685229484942 no 2737 0.235146148125895 3680 17201110
SGTC_174 3553-0389 74.3 µM -0.723032122096768 0.194364379742741 no 2738 0.234830074769068 3686 738071
SGTC_2990 9074105 71.4286 µM -0.724566199677223 0.193886443673637 no 2739 0.234359100547111 3669 6502001
SGTC_390 dec-rvkr-cmk 16.7 µM -0.727170307364536 0.193076785460198 no 2740 0.233560816622496 3776 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.728240674800404 0.192744590830723 no 2741 0.233233135460027 3775 4213774
SGTC_2212 7123476 200 µM -0.728832451164882 0.192561079668133 no 2742 0.233052079256652 3675 1085715
SGTC_2387 9077560 195.08 µM -0.729150849843125 0.192462387735982 no 2743 0.232954696286173 3721 5303272
SGTC_821 1114-0266 29.2 µM -0.729475571779856 0.192361767683727 no 2744 0.232855402616269 3745 3123235
SGTC_2062 5245942 200 µM -0.730405847068366 0.19207368581007 no 2745 0.23257107268838 3804 1376160
SGTC_1082 camptothecin 424.86 nM -0.730591781757286 0.192016138381732 no 2746 0.232514266646886 3675 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2796 7949634 45.45 µM -0.730638919491841 0.192001550766867 no 2747 0.232499866535956 3706 2971588
SGTC_2666 tannic acid 100 µM -0.73075462646372 0.191965746051197 no 2748 0.232464521305134 3726 16134267 A thiamine antagonist.
SGTC_931 2812-0076 566 µM -0.733609378444662 0.191083657622169 no 2749 0.231593421712307 3752 3450959
SGTC_2198 6589944 200 µM -0.735251203589236 0.190577478536347 no 2750 0.231093260093441 3716 5290268
SGTC_1824 st053723 68.6 µM -0.736035603224745 0.190335936883206 no 2751 0.230854515466012 3713 675225
SGTC_2534 helenine 20.12 µM -0.73633303562381 0.190244397155448 no 2752 0.230764023166561 3746 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1228 0124-0032 52.5 µM -0.736443771949116 0.190210323134894 no 2753 0.23073033726314 3787 X1228
SGTC_2585 alliin 100 µM -0.736960023672559 0.190051519858758 no 2754 0.230573330151522 3782 87310 A garlic compound which reacts with lipids.
SGTC_1502 4534-4282 27.7 µM -0.738077914805626 0.18970792672263 no 2755 0.230233551765076 3707 3278949
SGTC_1562 morin hydrate 59.1 µM -0.740451009547173 0.188979803751324 no 2756 0.229513188536954 3774 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_130 0136-0219 337.655 µM -0.741861792619526 0.188547758398218 no 2757 0.229085538485792 3673 234244
SGTC_1673 st016611 27.3 µM -0.743287325780391 0.188111815078698 no 2758 0.228653871635208 3770 5226799
SGTC_3001 9076041 71.4286 µM -0.743731994618375 0.187975957973496 no 2759 0.228519314625058 3748 16004211
SGTC_1610 st001799 48.1 µM -0.743781057104292 0.187960971906523 no 2760 0.228504471017718 3675 621897
SGTC_2752 diclazuril 33.15 µM -0.74448217111078 0.18774689821633 no 2761 0.228292411700023 3782 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2136 5328288 199.296 µM -0.744746077964208 0.187666357603946 no 2762 0.228212618955366 3752 262395
SGTC_2415 st077333 57.7 µM -0.745095079354893 0.187559880134438 no 2763 0.228107121794931 3754 2766255
SGTC_410 α-linolenic acid 100 µM -0.745750264221698 0.187360089437426 no 2764 0.227909144685664 3830 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2541 muurolladie-3-one 83.07 µM -0.746361993920956 0.187173668677965 no 2765 0.227724385717078 3765 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_886 0866-0150 153 µM -0.747039307207151 0.186967395603642 no 2766 0.22751991711063 3766 271463
SGTC_2526 patulin 37.61 µM -0.747628263053123 0.186788145805017 no 2767 0.227342206084269 3804 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2254 7938975 95.19 µM -0.74995683237362 0.186080483600397 no 2768 0.226640351975459 3792 2969277
SGTC_2528 xanthyletin 44.79 µM -0.750575878072201 0.185892632958786 no 2769 0.226453971387617 3813 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_39 0986-0283 58.349 µM -0.751104994556531 0.185732164765722 no 2770 0.226294735067927 3801 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2586 curcumin 80 µM -0.751197827489987 0.18570401965258 no 2771 0.226266803746004 3773 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2857 9024691 58.44 µM -0.751508837139511 0.185609746947881 no 2772 0.226173242197813 3831 16478292
SGTC_1463 k081-0032 34.1 µM -0.75156760067059 0.185591937984512 no 2773 0.226155566723225 3575 977755
SGTC_1608 st001473 40.5 µM -0.752602822600363 0.185278375979219 no 2774 0.22584431049055 3727 7292267
SGTC_520 3584-0023 682 µM -0.753416991861913 0.185032000630834 no 2775 0.225599687606221 3785 1340790
SGTC_392 N-ethylmaleimide 8.33 µM -0.753487024211752 0.185010817688076 no 2776 0.22557865289942 3725 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2593 nobiletin 86.24 µM -0.754154577085864 0.184808976149736 no 2777 0.225378204439023 3764 72344 An anti-infammatory.
SGTC_880 0833-0487 87.2 µM -0.75430810927787 0.184762573465284 no 2778 0.225332117053862 3742 76075
SGTC_798 1287-0182 476 µM -0.754567631456979 0.184684153448252 no 2779 0.225254225666775 3777 1649755
SGTC_286 k060-0067 22.9 µM -0.755780606750721 0.184317902226072 no 2780 0.224890373006506 3749 5985051
SGTC_271 rotenone 740 µM -0.757054244690223 0.183933821017129 no 2781 0.2245086823882 3778 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_911 3456-4043 236 µM -0.759112450472021 0.183314198089711 no 2782 0.223892645950844 3850 914281
SGTC_3108 9121785 49.47 µM -0.75945943850316 0.18320986568511 no 2783 0.223788884535665 3678 17140271
SGTC_1390 3413-2614 145 µM -0.759674902974959 0.18314509844304 no 2784 0.223724466970016 3820 3421432
SGTC_1286 0929-0070 131 µM -0.75976962075711 0.183116631403236 no 2785 0.223696152463668 3847 1420408
SGTC_998 3996-0085 177 µM -0.761100766875453 0.18271685293622 no 2786 0.223298441234573 3803 715391
SGTC_473 2-arachidonoylglycerol 10 µM -0.761708134902111 0.182534625393304 no 2787 0.223117109525113 3668 5282280 An endocannabinoid.
SGTC_1530 rhein 70.4 µM -0.7621787995587 0.182393490809418 no 2788 0.222976648731899 3822 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1677 st019204 53.9 µM -0.762451221262473 0.182311832971301 no 2789 0.222895372743673 3802 3945625
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.762644387922553 0.182253945511604 no 2790 0.222837752426799 3798 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1637 st007924 17.4 µM -0.762964900236334 0.182157920929542 no 2791 0.222742164483245 3749 683336
SGTC_1752 st044819 83.042 µM -0.763009632434576 0.182144521804802 no 2792 0.222728825641068 3779 441209 YML126C ERG13
SGTC_3053 9095903 49.47 µM -0.764388975861449 0.18173165441629 no 2793 0.222317738173845 3842 17174018
SGTC_1616 st002734 56.1 µM -0.766059662650832 0.181232366390015 no 2794 0.221820401424263 3760 4026101
SGTC_1370 2001-0092 44.6 µM -0.76675201817754 0.18102570660903 no 2795 0.221614484647051 3836 790957
SGTC_1195 1502-0147 41.1 µM -0.767485883442258 0.180806817938234 no 2796 0.221396341570071 3769 817940
SGTC_2233 sulbentine 40.3845 µM -0.767847565563139 0.180699000723068 no 2797 0.221288875940499 3753 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_304 1310-0298 97 µM -0.770306891471243 0.179966946557165 no 2798 0.220558934697098 3718 1550234
SGTC_3231 9132313 49.47 µM -0.770901740499307 0.179790161176474 no 2799 0.220382587706093 3784 4905967
SGTC_1276 0871-0068 94.2 µM -0.772823252277788 0.179219845688704 no 2800 0.219813495148645 3786 3414906
SGTC_1633 st005664 67.9 µM -0.774008780194276 0.178868542556659 no 2801 0.219462799506927 3805 2063822
SGTC_2529 gangaleoidin 93.61 µM -0.774549118406608 0.178708570007867 no 2802 0.219303066649477 3829 4565183
SGTC_3308 9128332 17.569 µM -0.775359415608523 0.178468842282399 no 2803 0.219063654750743 3779 17332805 YDL196W YDL196W
SGTC_3207 9114163 49.47 µM -0.775692937612111 0.178370228140925 no 2804 0.218965155407497 3791 849233
SGTC_293 4049-0273 38.5 µM -0.775882421406851 0.178314217802999 no 2805 0.218909206343276 3683 1380311
SGTC_1416 3966-0321 25.3 µM -0.778238286042181 0.177618763260555 no 2806 0.218214274991447 3818 582530 YLR208W SEC13
SGTC_2882 9058044 58.44 µM -0.778646864885063 0.177498324611748 no 2807 0.218093882165744 3762 18076804
SGTC_205 1486-1330 71.903 µM -0.778717020164002 0.177477649806888 no 2808 0.218073213894405 3778 4118834
SGTC_1046 2001-0062 216 µM -0.778754789241056 0.177466519865615 no 2809 0.218062087308595 3714 739778
SGTC_1738 st035555 74 µM -0.779300220231082 0.177305839227314 no 2810 0.21790144249119 3829 5331140
SGTC_1395 3486-0190 4.35 µM -0.784266685751692 0.17584697793087 no 2811 0.2164418214988 3796 6748079
SGTC_3291 9121177 71.43 µM -0.785251095720537 0.175558720372686 no 2812 0.216153181382939 3815 17015612
SGTC_558 k064-0027 21.3 µM -0.785567489840094 0.175466136628774 no 2813 0.216060458412344 3851 5088526
SGTC_2634 4'-methoxyflavone 100 µM -0.786310850848329 0.175248734966959 no 2814 0.215842698513548 3834 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_348 k064-0012 10.7 µM -0.786391714089597 0.175225096193866 no 2815 0.215819018138565 3733 5066323
SGTC_2656 pseudo-anisatin 100 µM -0.786622390456218 0.175157673622204 no 2816 0.215751474052457 3855 6708809 A neurotoxin.
SGTC_2294 7971431 200 µM -0.787769339398127 0.174822685332181 no 2817 0.215415819208201 3776 5741572
SGTC_329 k048-0121 21.3 µM -0.789245997325 0.174391998459643 no 2818 0.214984121360612 3819 6832902
SGTC_265 mycophenolic acid 32.932 µM -0.789520979762641 0.174311870693569 no 2819 0.214903786347709 3884 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2456 5770359 74.46 µM -0.791864285428136 0.173629998739091 no 2820 0.214219906767057 3803 3118787
SGTC_1932 st074806 40.9 µM -0.793489960810544 0.17315794651503 no 2821 0.213746208030156 3886 17251235
SGTC_1757 st041620 31.8375 µM -0.793880574913444 0.173044644635615 no 2822 0.213632479597622 3900 5289815
SGTC_1784 st039334 36.3 µM -0.794347268037103 0.172909337142548 no 2823 0.213496646769836 3865 3496984
SGTC_795 0685-0265 78 µM -0.794856327254443 0.172761823421405 no 2824 0.213348540537144 3861 302754
SGTC_2086 5274770 176.623 µM -0.796091924743871 0.172404109278517 no 2825 0.21298930371955 3877 689278
SGTC_1246 0422-0085 105 µM -0.796835966824259 0.17218893194842 no 2826 0.212773151767344 3840 264295
SGTC_2396 5342950 42.78 µM -0.798468195871981 0.171717491184093 no 2827 0.212299421132842 3846 1886677
SGTC_2144 5628481 200 µM -0.799215130129051 0.171502027555145 no 2828 0.212082840129014 3825 2818399
SGTC_148 3253-0744 288.01 µM -0.80036768608618 0.171169895812454 no 2829 0.211748898696741 3778 6893655
SGTC_142 0335-0849 62.6745 µM -0.800928151594097 0.171008535357127 no 2830 0.211586620744483 3848 3889043 YPR107C YTH1
SGTC_2743 auranofin 4.32 µM -0.801320866974613 0.17089552888962 no 2831 0.211472956787248 3787 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_22 0964-0034 14.468 µM -0.80282369751218 0.170463520795006 no 2832 0.211038321571758 3862 138402
SGTC_2889 9059656 51.95 µM -0.803234793007634 0.170345467999493 no 2833 0.210919519479726 3919 3949838
SGTC_3164 9100705 49.47 µM -0.805529632028309 0.169687429867505 no 2834 0.210257056952241 3848 17174235
SGTC_2987 9018338 71.43 µM -0.805578018931393 0.169673572644249 no 2835 0.210243102031832 3883 5055682
SGTC_1802 st050112 57.9 µM -0.807737207536497 0.169055955041819 no 2836 0.209620939769417 3844 4662563
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.808269291703737 0.16890397889202 no 2837 0.209467788132289 3867 6728940
SGTC_2849 9019321 12.99 µM -0.809411887054345 0.168577922639684 no 2838 0.209139133491419 3858 16489627
SGTC_1631 benzylvanillin 81.9 µM -0.809925092017269 0.16843160389094 no 2839 0.208991614749025 3920 75506
SGTC_1165 k072-0275 30.3 µM -0.811086777296789 0.168100700080453 no 2840 0.208657919359516 3827 6153523 YGL055W OLE1
SGTC_1484 3473-2379 286 µM -0.811203151838118 0.168067574084503 no 2841 0.208624507958681 3954 671917
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.811262369391478 0.168050719429458 no 2842 0.208607507672498 3863 91467 include heat shock
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.814318891096279 0.167182241422224 no 2843 0.207731145117377 3682 6708630 An antioxidant.
SGTC_98 0074-0023 107.663 µM -0.816245995880006 0.166636165091685 no 2844 0.207179727346276 3822 3563821
SGTC_3177 9107506 49.47 µM -0.816264211534426 0.166631008889187 no 2845 0.207174519290436 3759 8897194
SGTC_1398 3558-0053 112 µM -0.817766798542785 0.166206034648252 no 2846 0.206745179850404 3759 4532369
SGTC_1895 st058434 18.3 µM -0.820361068045115 0.165473950978668 no 2847 0.206005151301492 3878 5393175
SGTC_1127 asiatic acid 681.4 nM -0.823891691728386 0.164480991466089 no 2848 0.205000550809215 3843 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_3310 9130229 44.1445 µM -0.824446399350896 0.164325336189317 no 2849 0.204842979939498 3948 7761258
SGTC_1357 1503-1303 39.5 µM -0.826716486900977 0.163689327495087 no 2850 0.204198887202777 3846 292895
SGTC_730 1436-0052 41.2 µM -0.828333073387246 0.163237385221458 no 2851 0.203740948700997 3889 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.829824656106378 0.162821109587067 no 2852 0.203318964186183 3861 16486 A toxic proline analog.
SGTC_3079 9117512 49.47 µM -0.830040122885442 0.162761033549437 no 2853 0.203258049498615 3894 7185044
SGTC_1899 st063254 59.6 µM -0.832501501893239 0.162075779692664 no 2854 0.20256296539463 3811 3093813
SGTC_3331 9141060 1.957 µM -0.833173949585698 0.161888895890731 no 2855 0.202373316118732 3856 4906567 YPR165W RHO1
SGTC_1846 st056244 14.8 µM -0.83414009929861 0.161620633535947 no 2856 0.202101020518365 3908 5393182
SGTC_918 glabranin 770.725 nM -0.83433726432993 0.161565924064723 no 2857 0.202045479296706 3916 124049 Also referred to as licorice root.
SGTC_1867 st057372 64 µM -0.834651586255356 0.161478730797132 no 2858 0.201956953969557 3858 688837
SGTC_3256 9138902 49.47 µM -0.834709573220495 0.161462648498525 no 2859 0.201940625113091 3918 17228773
SGTC_1033 k072-0102 21.3 µM -0.839358694186351 0.160176644633333 no 2860 0.20063402779764 3849 5965931
SGTC_87 0100-0052 35.5 µM -0.83948026520642 0.160143106679999 no 2861 0.200599929496793 3957 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1746 st038117 42 µM -0.840436854494121 0.159879371359618 no 2862 0.20033174627849 3963 2898218
SGTC_428 3448-4153 16.5 µM -0.841191171530102 0.159671603728596 no 2863 0.200120422783848 3858 3834874
SGTC_1635 st007035 42.4 µM -0.84157737962945 0.159565295731859 no 2864 0.200012277660799 3874 3716403
SGTC_1258 0671-0043 57.1 µM -0.846200561648117 0.158296311687319 no 2865 0.198720434339447 3935 4298767
SGTC_2842 9000675 19.48 µM -0.846665674414275 0.158169013828707 no 2866 0.198590748249633 3954 2989072
SGTC_2506 ethyl hematommate 54.16 µM -0.847087389378441 0.158053651712441 no 2867 0.198473206782862 3984 3940691 An allergen.
SGTC_2771 fluoxetine 41.05 µM -0.852133671878764 0.156677503264664 no 2868 0.197069952568067 3867 3386 A selective serotonin reuptake inhibitor.
SGTC_2979 9012552 45.46 µM -0.853609792011336 0.156276452755353 no 2869 0.19666061558391 3945 17100905
SGTC_969 1313-0238 134 µM -0.8538384267492 0.156214394988708 no 2870 0.196597259892864 3922 5212874
SGTC_2276 7947513 42.08 µM -0.857807743001615 0.1551396011038 no 2871 0.195499316742529 3869 2105100
SGTC_3333 9141820 12.094 µM -0.860909240888624 0.15430319691389 no 2872 0.194644015860123 3913 1939433
SGTC_1114 scopoletin 1.73284 µM -0.861488550879734 0.154147301159768 no 2873 0.194484512112364 3911 5280460 A coumarin with genotoxic properties.
SGTC_2314 7727897 200 µM -0.863974398246512 0.153479527973683 no 2874 0.193800977376512 3937 900724
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.868091832359673 0.152377682725645 no 2875 0.192672030993797 3905 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1737 st035557 69.7 µM -0.869345038976536 0.152043363369257 no 2876 0.192329217541094 3824 5716916
SGTC_2364 9055074 200 µM -0.869808198057739 0.151919929280598 no 2877 0.19220261528884 3948 6470630
SGTC_3239 9133757 49.47 µM -0.871302303435705 0.151522196990428 no 2878 0.191794556555099 3934 17036923
SGTC_1729 st035615 45.989 µM -0.87154163555155 0.151458550936313 no 2879 0.191729241305844 3976 17385451
SGTC_1646 st011709 75.6 µM -0.872024668704822 0.151330151141452 no 2880 0.191597459993517 3861 5757843
SGTC_1135 dihydrocapsaicin 536.708 nM -0.874823456671871 0.150587603079216 no 2881 0.190834986056988 3859 107982 A Capsaicinoid.
SGTC_2892 9047358 58.44 µM -0.875736877722922 0.15034578892579 no 2882 0.190586546217771 3936 6466771
SGTC_1402 3909-7673 35.9 µM -0.875802211444816 0.15032850275013 no 2883 0.190568783821795 3931 5328014
SGTC_1623 st003709 20.3 µM -0.877872998181928 0.149781294525995 no 2884 0.190006322026005 3903 16192618
SGTC_622 1348-1566 26.3 µM -0.882462085237498 0.148573362390005 no 2885 0.188763487195379 3990 7340407
SGTC_2411 st077133 39.94 µM -0.885370359734911 0.147811232012765 no 2886 0.187978456614452 4060 1403142 YNL221C POP1
SGTC_829 1635-0120 117 µM -0.889537091346788 0.146723884928484 no 2887 0.186857249149816 3971 285054
SGTC_3039 9090270 49.47 µM -0.890190990181666 0.146553732450365 no 2888 0.186681670847521 3946 17173750
SGTC_3272 9137413 49.47 µM -0.891043418000054 0.146332119231617 no 2889 0.186452938966245 3893 17614870
SGTC_414 piperonyl butoxide 100 µM -0.8912063779878 0.146289778712147 no 2890 0.186409231699673 3945 5794 A potent inhibitor of cytochrome P450.
SGTC_1930 st074634 34.3 µM -0.893929340817467 0.145583511434026 no 2891 0.185679849003856 3885 684253 YOR116C RPO31
SGTC_500 h-89 112 µM -0.894760944215677 0.145368272466242 no 2892 0.185457446129538 4003 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1783 st039459 87.517 µM -0.895797680519013 0.145100240091106 no 2893 0.185180414462188 4070 729761
SGTC_2962 9082311 13.18 µM -0.895849500667 0.145086851515165 no 2894 0.185166574080272 3957 16459453
SGTC_2773 thioridazine 9.09 µM -0.895970904853282 0.14505548802994 no 2895 0.185134151364462 3990 5452 An antipsychotic.
SGTC_119 0121-0043 24.815 µM -0.897653529536049 0.144621269693372 no 2896 0.184685145687297 3985 1092378
SGTC_2827 7993847 71.43 µM -0.899386853726837 0.14417488430863 no 2897 0.184223319539573 4048 2985692
SGTC_1902 st060212 70.5 µM -0.901428344985419 0.143650328752129 no 2898 0.183680308125379 3969 688944
SGTC_675 1309-0189 238 µM -0.901502711052131 0.143631244940965 no 2899 0.183660546515455 3993 4246530
SGTC_86 0417-1630 471.922 µM -0.90351116621083 0.1431164825251 no 2900 0.183127332338566 3982 3634867
SGTC_903 1134-0042 114 µM -0.904992452717585 0.142737631719415 no 2901 0.182734692781607 3997 701009
SGTC_1804 st050076 49.1 µM -0.905286753105165 0.142662442859899 no 2902 0.18265674621192 4008 3895976
SGTC_3282 9108498 15.4605 µM -0.905944654400528 0.142494456869324 no 2903 0.18248257366181 3972 16459645
SGTC_1781 st038725 66.3 µM -0.907059967545916 0.142209982844105 no 2904 0.182187543165004 3974 4270275 YIL048W NEO1
SGTC_490 phenamil 164 µM -0.907666658224698 0.142055400587966 no 2905 0.182027182338096 3955 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2380 9035439 200 µM -0.907774659687983 0.142027894195955 no 2906 0.18199864458601 4097 6462575
SGTC_788 1182-0090 188 µM -0.908383480623548 0.141872903865048 no 2907 0.181837825208005 4039 5715185
SGTC_219 mitoxanthrone 164.414 µM -0.908751001803863 0.141779397772416 no 2908 0.181740787931319 3947 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1415 3966-0071 78.1 µM -0.908921509688721 0.141736030705237 no 2909 0.181695779432353 3925 2893185
SGTC_2896 9052656 71.43 µM -0.90899478322327 0.141717397035415 no 2910 0.181676439760979 3864 6469436
SGTC_2288 7946289 167.31 µM -0.909625895913335 0.141556971963677 no 2911 0.181509918456954 4036 1246052
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.913238218216742 0.14064110935662 no 2912 0.180558633821221 3775 4000243
SGTC_579 4491-1009 110 µM -0.913444633803862 0.140588896814456 no 2913 0.180504370053884 4114 1271041
SGTC_2302 7771753 200 µM -0.913877515524704 0.14047944270456 no 2914 0.180390604735659 3997 2203047
SGTC_3311 9131146 2.8755 µM -0.915144278664857 0.140159474169385 no 2915 0.180057946187563 3962 4900406 YPR165W RHO1
SGTC_440 fluspirilene 35.1 µM -0.915468332756736 0.140077701741251 no 2916 0.179972909812952 4088 3396 An atypical antipsychotic.
SGTC_185 k048-0037 25.491 µM -0.915853719493694 0.139980494720642 no 2917 0.17987181172129 4032 6827589
SGTC_936 3005-4620 401 µM -0.915957893602921 0.139954226507395 no 2918 0.179844489963593 4007 777207
SGTC_1969 st069479 40.1 µM -0.916793784346143 0.13974357222859 no 2919 0.179625355169718 4001 3895485
SGTC_6 0844-0013 19.835 µM -0.917642711130029 0.139529853447022 no 2920 0.179402974698429 4123 1584900
SGTC_2782 7736369 71.43 µM -0.918916527265911 0.13920958526383 no 2921 0.179069617283646 4028 2950836 YOL077C BRX1
SGTC_769 0302-0231 76 µM -0.921787537511515 0.138489579444361 no 2922 0.178319704635003 3936 571869 YER009W NTF2
SGTC_2295 7971645 200 µM -0.923013920557013 0.138182796040356 no 2923 0.177999975428508 4056 2978226 YKL099C UTP11
SGTC_2830 7992007 71.43 µM -0.924126939077465 0.1379047724912 no 2924 0.177710114491316 3891 1952075
SGTC_2926 9010726 65.15 µM -0.924591446013046 0.137788855133727 no 2925 0.177589232112553 4044 2994293
SGTC_1030 k029-0042 36.7 µM -0.925193148418638 0.137638799611911 no 2926 0.177432723418091 3993 6080581
SGTC_1338 1486-1223 76 µM -0.926729397447152 0.137256188279082 no 2927 0.177033525095783 4027 3444526
SGTC_963 1269-2853 151 µM -0.92678656876942 0.13724196347836 no 2928 0.177018679938535 3984 3668223
SGTC_1979 st071809 45.3 µM -0.927509266272028 0.137062235873793 no 2929 0.176831091468203 4097 4976333
SGTC_108 0509-0257 621.132 µM -0.927711010646048 0.137012092800438 no 2930 0.176778747714985 3972 536624
SGTC_3138 9097216 49.47 µM -0.928021063783031 0.136935054285837 no 2931 0.17669832171819 3977 25237486
SGTC_2992 9074591 71.4286 µM -0.929374293687321 0.136599165538866 no 2932 0.176347572565712 3960 17741321
SGTC_739 1486-1183 203 µM -0.931516367161641 0.13606862847961 no 2933 0.175793261102448 4012 4346692
SGTC_608 k048-0125 159 µM -0.93405310559672 0.135442169352983 no 2934 0.175138249988109 4062 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_15 0266-0086 27.098 µM -0.939143482592425 0.134191047703561 no 2935 0.173828540895616 4077 1712902 YIL048W NEO1
SGTC_2452 5863136 48.41 µM -0.939344417011093 0.134141825090997 no 2936 0.173776970362408 3987 2184096
SGTC_1860 st056228 74.6 µM -0.940085496917375 0.133960391060755 no 2937 0.173586853714684 4008 688679
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.940554690533804 0.133845608496006 no 2938 0.173466555228664 3969 6708514
SGTC_2440 5628896 157.78 µM -0.941583238788131 0.133594223130799 no 2939 0.173203027211637 4017 5522048
SGTC_2998 9066762 71.4286 µM -0.9425126316794 0.133367351518527 no 2940 0.172965123534343 4062 4945196
SGTC_3009 9080819 71.4286 µM -0.943765085239235 0.133062037894358 no 2941 0.172644853095361 4040 17027216
SGTC_3159 9100096 49.47 µM -0.943843212323527 0.133043008620769 no 2942 0.172624887409007 3977 25236875
SGTC_1927 st060202 13.8 µM -0.945527006475949 0.132633345101534 no 2943 0.172194944931638 3906 688887
SGTC_2403 6032726 181.2 µM -0.945619882822645 0.132610773799478 no 2944 0.172171249650975 4089 2881040
SGTC_3130 9127414 49.47 µM -0.946877843539746 0.132305318146849 no 2945 0.171850514658141 4031 1494646
SGTC_1344 1488-0097 29.1 µM -0.952843502367078 0.130863353519504 no 2946 0.170334684616651 4061 747966
SGTC_2706 st078239 82.5 µM -0.953672326388974 0.130663880336199 no 2947 0.170124766193607 4002 15434492
SGTC_3170 9103054 49.47 µM -0.953888600138448 0.130611864306116 no 2948 0.170070017262546 4040 16432970
SGTC_2469 5655019 90.81 µM -0.95418965525213 0.130539481337095 no 2949 0.169993825032637 4093 2788239
SGTC_3154 9100113 49.47 µM -0.958050102800357 0.129613768304117 no 2950 0.169018747290997 4070 25237525
SGTC_2135 5326629 150.42 µM -0.960337456406257 0.129067424449392 no 2951 0.168442702227062 4010 5020077
SGTC_302 1094-0063 18.9 µM -0.961103202691053 0.12888488006269 no 2952 0.168250139764278 4021 5440289
SGTC_1364 1653-0028 37.6 µM -0.96402058984656 0.128191052407307 no 2953 0.167517801568329 4036 5718652
SGTC_3169 9102970 49.47 µM -0.966000263791334 0.12772171630792 no 2954 0.167022024518477 4103 17027839
SGTC_2203 7227154 166.4 µM -0.966282955069189 0.127654794153535 no 2955 0.166951306381591 4032 896304
SGTC_2867 9039098 71.43 µM -0.967858861455059 0.1272821729446 no 2956 0.166557431122407 4010 6463460
SGTC_981 1488-1094 54.9 µM -0.973045612222315 0.126061117872946 no 2957 0.165265316557114 4030 3449522
SGTC_2471 5466956 24.79 µM -0.975594442591052 0.125464079277313 no 2958 0.16463273981214 4024 724419
SGTC_94 0334-0113 514.748 µM -0.977065342502445 0.12512043480774 no 2959 0.164268402139347 4083 6795178
SGTC_409 arachidonic acid 100 µM -0.978230558548146 0.124848673887956 no 2960 0.163980152905133 4064 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_340 k038-0059 454 µM -0.978311118144539 0.124829900394898 no 2961 0.163960236340311 4044 23733424
SGTC_3112 9123419 49.47 µM -0.983651085641825 0.123589878548292 no 2962 0.162643548953161 4109 17015854
SGTC_2750 bromebric acid 70.15 µM -0.984307483254845 0.123438050463312 no 2963 0.162482175611493 4131 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1146 3579-1023 7 µM -0.984746305126451 0.123336621646468 no 2964 0.162374350730896 4113 X1146
SGTC_2028 5153890 36.43 µM -0.984986279025067 0.123281179041284 no 2965 0.162315405376282 4039 2830968 YPR165W RHO1
SGTC_540 1187-0821 17.3 µM -0.988924126711282 0.122373888299182 no 2966 0.161350132587265 4025 847520
SGTC_364 0083-0097 67.7 µM -0.989588709810348 0.122221229946235 no 2967 0.161187595328332 4165 5207356
SGTC_1588 farnesol 29.9 µM -0.990064360219484 0.122112052577803 no 2968 0.161071330995307 4071 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3070 9117005 49.47 µM -0.990950327288164 0.12190887669038 no 2969 0.160854917945653 4155 8779016
SGTC_1272 0839-0021 27 µM -0.991037056679742 0.121889000094935 no 2970 0.160833742970915 4093 5027250
SGTC_1426 4048-4480 71.7 µM -0.991876325841477 0.121696774437169 no 2971 0.160628929483288 4076 14224343
SGTC_1205 4161-2785 76 µM -0.991934941610488 0.121683357082904 no 2972 0.160614631380879 4162 3498106
SGTC_3313 9133968 57.047 µM -0.99603923415537 0.120746453756463 no 2973 0.15961554128553 4081 1494643
SGTC_577 r071-0003 38.6 µM -0.996628915460176 0.120612263149853 no 2974 0.159472332600549 4103 4568517 YMR134W ERG29
SGTC_2366 9070441 60.58 µM -0.996690696642345 0.120598210017242 no 2975 0.159457333429972 4083 6837235
SGTC_976 1348-1067 47.6 µM -0.997757667021108 0.120355692154912 no 2976 0.159198441187783 4098 5310671 YGL099W LSG1
SGTC_814 3342-0569 96 µM -0.998806108123456 0.120117720752474 no 2977 0.158944313263632 4144 4346283
SGTC_1725 st036284 20.55 µM -1.0002604504671 0.119788168618635 no 2978 0.158592240750207 4177 707914
SGTC_796 1234-0020 70.7 µM -1.00617860818299 0.118453698933712 no 2979 0.157164830243839 4017 46495034
SGTC_2648 atorvastatin 78.68 µM -1.00703706477008 0.118261003895871 no 2980 0.156958481450261 4105 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_382 3229-0966 23.2 µM -1.01025276850596 0.11754115548746 no 2981 0.156187101777383 4132 5722370
SGTC_1702 st027038 51 µM -1.0135933010865 0.116796654451509 no 2982 0.155388427745606 4120 5521182
SGTC_3326 9140064 16.379 µM -1.01438233262261 0.116621292928611 no 2983 0.155200175628863 4029 1868434
SGTC_975 1335-0046 28.5 µM -1.01535413801826 0.116405566782331 no 2984 0.154968523158822 4119 16486740
SGTC_2933 9026794 32.47 µM -1.01587768262337 0.116289465177926 no 2985 0.154843818793241 4062 17586027
SGTC_1467 k284-1082 293 µM -1.01722966201296 0.115990029432729 no 2986 0.154522094226378 4070 3334705
SGTC_1512 0259-0544 12.2 µM -1.01982700855462 0.115416307152487 no 2987 0.153905255791043 4075 18476
SGTC_3163 9099914 49.47 µM -1.0224332957744 0.114842640002277 no 2988 0.153287934233273 4115 16268368
SGTC_1480 1070-0044 41.2 µM -1.02851199976306 0.113512552715465 no 2989 0.15185452457286 4131 3124987
SGTC_52 0329-0193 875 nM -1.02935468489092 0.113329034433506 no 2990 0.151656517464379 4216 3739292
SGTC_889 0919-1524 82.7 µM -1.03147138135146 0.112868998202898 no 2991 0.151159911021051 4148 3905452
SGTC_1788 fluconazole 20 µM -1.03319233885977 0.112495954396519 no 2992 0.150756948706215 4169 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2306 7482397 179.52 µM -1.03322421887976 0.112489052234469 no 2993 0.150749490751021 4138 891448
SGTC_1283 0922-0125 16.4 µM -1.03604132918086 0.111880329689428 no 2994 0.150091430875001 4127 3360884
SGTC_759 3486-0358 89.3 µM -1.03618769237948 0.111848767958076 no 2995 0.150057293732257 4129 875103
SGTC_2715 st079500 56.4 µM -1.03687653578113 0.111700311408613 no 2996 0.14989670028193 4096 28246688
SGTC_2407 paclitaxel 400 µM -1.0385885684853 0.111331952187198 no 2997 0.149498062292362 4242 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3196 9111891 49.47 µM -1.040108426806 0.111005670336154 no 2998 0.149144764528814 4117 18891510
SGTC_2687 chenodiol 100 µM -1.04092076191515 0.110831560069812 no 2999 0.14895616250336 4225 5702181 A cholesterol synthesis inhibitor.
SGTC_2776 terbinafine 19.92 µM -1.04444969116509 0.110077465136627 no 3000 0.148138691815337 4160 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_694 1315-0438 43.2 µM -1.04668484885165 0.109601743651459 no 3001 0.14762247694924 4121 6793154
SGTC_2728 chlorpromazine 9.18 µM -1.04825736409095 0.109267941955731 no 3002 0.147260023772979 4180 2726 A thorazine and dopamine antagonist.
SGTC_3031 9088762 49.47 µM -1.04935546611154 0.109035278628604 no 3003 0.147007273343701 4118 205253
SGTC_2832 7992762 51.95 µM -1.05161678601318 0.108557277457941 no 3004 0.146487701607826 4082 2985177
SGTC_3222 9128301 49.47 µM -1.05182863127263 0.108512574634666 no 3005 0.146439090248287 4157 4911358
SGTC_2056 5235370 200 µM -1.05274776496523 0.108318775727824 no 3006 0.146228305421988 4082 5511916
SGTC_2095 5432005 200 µM -1.0534120485797 0.108178866985578 no 3007 0.146076092245943 4156 783734
SGTC_1812 st052057 4.327 µM -1.05550332627409 0.107739259973921 no 3008 0.145597594512018 4163 3645418
SGTC_771 0250-0039 27.3 µM -1.05642709962735 0.107545484116284 no 3009 0.145386565217952 4112 3005115
SGTC_3259 9138485 49.47 µM -1.0636372919465 0.106041659599341 no 3010 0.143746520954293 4155 17646153
SGTC_592 k241-0073 46.5 µM -1.06786134203028 0.105167741604362 no 3011 0.142791531357787 4192 4230158
SGTC_504 lovastatin 124 µM -1.06923970374468 0.104883701915279 no 3012 0.142480836185693 4182 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2401 5128683 200 µM -1.07047978008156 0.104628633759296 no 3013 0.142201702797605 4166 708373
SGTC_3348 9149464 3.537 µM -1.07065868045016 0.104591873313558 no 3014 0.142161464014697 4111 1951442
SGTC_2943 9068529 45.32 µM -1.07378759473696 0.103950456142297 no 3015 0.141458945574971 4159 3270634
SGTC_745 0469-0705 296 µM -1.07415624298904 0.10387507271343 no 3016 0.141376330136505 4232 3486736
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.07646855536071 0.103403141257417 no 3017 0.140858878298979 4199 688664
SGTC_3076 9116187 49.47 µM -1.08010166060074 0.10266478955276 no 3018 0.140048456242914 4156 27241210
SGTC_289 k017-0060 526 µM -1.08573048680277 0.101528429575509 no 3019 0.138799124236011 4159 5512909
SGTC_529 4076-0302 30.3 µM -1.08607892083331 0.101458389210781 no 3020 0.138722038683883 4136 5816522
SGTC_2540 epiandrosterone 100 µM -1.08712711070638 0.101247899826281 no 3021 0.138490318985824 4221 441302 A steroid.
SGTC_518 1021-0119 62.6 µM -1.08792242698528 0.101088402996829 no 3022 0.138314677258374 4153 1097762
SGTC_1600 coumarin 106 71.1 µM -1.08839965835159 0.100992784511327 no 3023 0.13820935596035 4251 100336 A hepatotoxic, DNA x-linker.
SGTC_2016 5121758 140 µM -1.08918928081511 0.100834719900186 no 3024 0.138035212453717 4096 2795203
SGTC_655 k060-0012 42 µM -1.09273221502977 0.100127724639209 no 3025 0.137255695508747 4180 5994525
SGTC_1909 st060837 51.5 µM -1.09745618454592 0.0991906919586951 no 3026 0.136221012152226 4164 678937
SGTC_1343 1487-0095 224 µM -1.09786550602519 0.0991098030584636 no 3027 0.136131611081155 4202 4560101 YGL055W OLE1
SGTC_1047 2043-3044 82 µM -1.10244645321134 0.098207819181222 no 3028 0.135133812806876 4185 669592
SGTC_1157 4092-0394 27.6 µM -1.10554683194673 0.0976007791056619 no 3029 0.134461356716156 4283 3659885
SGTC_2269 7935389 174.42 µM -1.10697279733952 0.0973225071717662 no 3030 0.134152844812265 4172 97605
SGTC_339 3091-4833 71.4 µM -1.10697645555526 0.0973217940336699 no 3031 0.134152053972115 4065 3240077
SGTC_2904 7225135 42.03 µM -1.10730465438161 0.0972578300591915 no 3032 0.13408111634737 4302 4446116
SGTC_3243 9134147 49.47 µM -1.11056662951066 0.0966237669235357 no 3033 0.133377466681657 4288 24282180
SGTC_871 0574-0004 149 µM -1.11092823326661 0.0965536657312457 no 3034 0.133299620834292 4171 9551173
SGTC_233 rapamycin 362 pM -1.11130286124542 0.0964810790518059 no 3035 0.133219004114824 4198 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_773 4358-1457 44.6 µM -1.11138674985756 0.096464830567094 no 3036 0.133200956605253 4210 1186886
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.11368501894666 0.0960204578894049 no 3037 0.132707169224742 4263 6710655
SGTC_2937 9044753 11.33 µM -1.11421450592796 0.0959182947173084 no 3038 0.132593586887639 4149 6465530 YGL099W LSG1
SGTC_882 0843-0131 351 µM -1.1152662257101 0.0957156051899909 no 3039 0.132368177009086 4206 5425421
SGTC_2211 7117706 200 µM -1.11668191287707 0.095443268951275 no 3040 0.132065177026455 4128 822771
SGTC_2147 5545932 89.7195 µM -1.12120589374848 0.0945768131074835 no 3041 0.131100115785628 4237 797404
SGTC_599 1935-0052 86.5 µM -1.12987688894343 0.0929323325461624 no 3042 0.129264051765083 4210 9557311
SGTC_88 0180-0332 8.668 µM -1.13095044027607 0.0927302100282208 no 3043 0.129037975728498 4302 3101745
SGTC_2873 9040596 71.43 µM -1.1361327845084 0.0917590771307039 no 3044 0.127950498004038 4201 6463863
SGTC_1661 st013063 9.66 µM -1.13838339086782 0.0913396845633086 no 3045 0.127480213188501 4283 721395
SGTC_1914 st062367 72.6 µM -1.14061079773339 0.0909260159649518 no 3046 0.127015960931509 4228 978205
SGTC_781 4335-2806 94.4 µM -1.14183840449585 0.0906986227401596 no 3047 0.126760597814095 4290 845254
SGTC_2870 9038528 12.99 µM -1.14903222071975 0.0893745684358803 no 3048 0.12527134740665 4280 6463316
SGTC_1613 st002381 52.1 µM -1.15297641240145 0.0886547524661492 no 3049 0.124460033107407 4225 551167
SGTC_2467 5474540 200 µM -1.15375651128766 0.0885128971152406 no 3050 0.124300004104599 4202 5413519
SGTC_234 nsc-17383 10.7 µM -1.15966716733221 0.0874435771663781 no 3051 0.123092171339692 4266 408974
SGTC_200 k038-0079 37.545 µM -1.16347832268043 0.0867592173223902 no 3052 0.122317744092423 4220 3436683
SGTC_2464 5717415 7.67 µM -1.16692965571174 0.0861429304336785 no 3053 0.121619389282421 4234 5285744
SGTC_1557 sumaresinolic acid 42.3 µM -1.16867348644131 0.0858327915917465 no 3054 0.121267604069354 4239 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_452 diindolylmethane 8 µM -1.17087616172466 0.0854422430971705 no 3055 0.120824279169186 4250 3071 Inhibits expression of several cancer promoting factors.
SGTC_1256 0570-0116 285 µM -1.17569988930934 0.0845916164513542 no 3056 0.119857411438941 4264 410638
SGTC_658 3253-0951 102 µM -1.1757455505755 0.0845835949043357 no 3057 0.119848285234533 4261 1184878
SGTC_2140 5586273 200 µM -1.17825666028401 0.0841433334645999 no 3058 0.119347150088981 4233 854421
SGTC_930 2810-3379 265 µM -1.18197483086399 0.0834946059979525 no 3059 0.118607843907906 4290 1015764
SGTC_613 3914-0030 117 µM -1.18446431220601 0.0830623594838963 no 3060 0.118114657622151 3979 1145395
SGTC_550 4123-0385 25.7 µM -1.18461224428824 0.0830367272362723 no 3061 0.118085396806669 4294 5731123
SGTC_2705 st078069 42.8 µM -1.18663973783426 0.082686021947485 no 3062 0.11768487723087 4310 1530061
SGTC_2265 7929201 200 µM -1.1866593438471 0.0826826360516033 no 3063 0.117681008876471 4257 1265108
SGTC_2089 5281248 129.67 µM -1.18694316417842 0.0826336328733824 no 3064 0.117625019931406 4262 2737878
SGTC_1440 4100-1550 40 µM -1.18833990701091 0.0823927957927023 no 3065 0.11734976063529 4268 742806
SGTC_2730 imipramine 71.33 µM -1.18883138859618 0.0823081766051773 no 3066 0.11725301182623 4244 3696 A tricyclic antidepressant.
SGTC_951 1171-0579 82.7 µM -1.1899041038781 0.0821237127942474 no 3067 0.117042042652129 4234 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_220 paclitaxel 373.376 µM -1.18994073311448 0.0821174195443454 no 3068 0.117034843591743 4227 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2641 levomentholum 100 µM -1.19217892423515 0.0817335660438718 no 3069 0.116595547752487 4268 16666
SGTC_1891 st059073 26.2 µM -1.19648745092734 0.0809984568708902 no 3070 0.115753196404541 4359 688754
SGTC_378 3970-0959 8.33 µM -1.19746086495836 0.0808330688078978 no 3071 0.11556348624559 4314 6615653
SGTC_1972 st070201 17.4 µM -1.19788492386807 0.080761098794121 no 3072 0.115480909866466 4293 2829099
SGTC_2150 5556613 200 µM -1.19836764999626 0.0806792308564717 no 3073 0.115386960344114 4302 743190
SGTC_3120 9124077 49.47 µM -1.20318418043507 0.0798658008313514 no 3074 0.114452527635407 4420 18774327 YGL155W CDC43
SGTC_3036 9090181 49.47 µM -1.2095509657343 0.0788000967768852 no 3075 0.113225621633496 4338 25236586
SGTC_1780 st038448 24.544 µM -1.21004392463204 0.0787180344510996 no 3076 0.113131019281231 4323 728868 YDL195W SEC31
SGTC_2128 5255449 168.493 µM -1.21036556148384 0.0786645268393182 no 3077 0.113069325272163 4231 736008
SGTC_2369 9071472 200 µM -1.21087672097597 0.0785795468976521 no 3078 0.11297132783203 4333 17296037
SGTC_1290 0986-0249 10.2 µM -1.21294806574024 0.0782358993163196 no 3079 0.112574838535468 4150 53329
SGTC_1313 1220-0047 237 µM -1.21372649637668 0.0781070484319658 no 3080 0.112426091414674 4274 3528706
SGTC_517 1365-0151 113 µM -1.213786466057 0.0780971285443728 no 3081 0.112414637882428 4331 768657
SGTC_1573 oleylamine 1.06 µM -1.21397270086105 0.078066328597725 no 3082 0.112379074450716 4291 5356789 An amine of the fatty acid oleic acid.
SGTC_2105 5350118 200 µM -1.21546906801245 0.0778191902981804 no 3083 0.112093619664909 4262 2133313
SGTC_2070 5230947 200 µM -1.21695787152223 0.0775738909572631 no 3084 0.111810122542805 4401 2835538
SGTC_2817 7995342 71.43 µM -1.21713663519264 0.0775444768892988 no 3085 0.111776116980262 4295 18879975
SGTC_3263 9137018 49.47 µM -1.22347043087618 0.0765077608798675 no 3086 0.11057603290322 4262 43844957
SGTC_143 4032-1194 15.74 µM -1.23130381736533 0.0752402159704342 no 3087 0.109104627348248 4350 1806963
SGTC_1234 0326-0494 15.5 µM -1.23199206759459 0.0751296177345705 no 3088 0.108976023642558 4383 1547813
SGTC_907 3448-6986 75.5 µM -1.23449089673429 0.0747291108120755 no 3089 0.108510018400704 4343 590582
SGTC_173 1273-0061 2.693 µM -1.23567218368485 0.0745403447585271 no 3090 0.10829022059669 4277 2847414 YPL266W DIM1
SGTC_2114 5491910 81.25 µM -1.23630504451896 0.0744393653670461 no 3091 0.108172598361169 4355 2849228
SGTC_900 1112-0045 141 µM -1.24088505799066 0.0737116878866811 no 3092 0.107324106662023 4202 56211 YIL048W NEO1
SGTC_1864 st057645 30.4 µM -1.24096259253121 0.0736994160893207 no 3093 0.107309784057595 4356 688666
SGTC_2151 5563267 85.4165 µM -1.24476753008532 0.0730991056592741 no 3094 0.106608607392685 4383 5310824
SGTC_1885 st057546 99.9 µM -1.2472524474068 0.0727090811661929 no 3095 0.106152473755826 4360 702008
SGTC_720 r052-1644 49.9 µM -1.24765189032795 0.0726465348553279 no 3096 0.106079283383042 4341 1422863 YOR257W CDC31
SGTC_2521 angolensin 13.4 µM -1.24829909815836 0.0725452800424231 no 3097 0.105960772176748 4369 821428 A flavenoid.
SGTC_1510 1123-0200 71.5 µM -1.24956303796618 0.072347850068885 no 3098 0.105729606180518 4342 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2734 clemastine 41.6 µM -1.25000482780017 0.0722789387833494 no 3099 0.10564889187623 4382 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_114 0364-0001 490.298 µM -1.25117475579883 0.0720966939883656 no 3100 0.105435363107536 4364 4003655
SGTC_475 α-linolenic acid 10 µM -1.2592659214029 0.0708459261457172 no 3101 0.103967148972763 4353 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_3321 9137793 26.8275 µM -1.25987985725587 0.0707517059648481 no 3102 0.103856353048065 4296 4904192
SGTC_1710 st031758 61.5 µM -1.26069862241832 0.0706262006790972 no 3103 0.103708725238663 4375 5394341
SGTC_560 2332-1943 155 µM -1.26178794324978 0.070459488325112 no 3104 0.103512550874394 4312 21177716
SGTC_3303 9125618 40.5795 µM -1.26215443359068 0.0704034678026412 no 3105 0.103446610692515 4353 22695467
SGTC_1232 0279-0259 161 µM -1.26215637649026 0.0704031709086054 no 3106 0.103446261200714 4324 1560000
SGTC_97 0535-0701 19.132 µM -1.26498506482905 0.0699719397509742 no 3107 0.102938340882526 4235 2832013 YGL099W LSG1
SGTC_2443 5493264 126.67 µM -1.26577914995174 0.0698512482327452 no 3108 0.102796080905664 4378 5340055
SGTC_2032 5185112 25.99 µM -1.26593134493734 0.0698281347069983 no 3109 0.102768831568068 4212 5718189
SGTC_2836 9010338 19.48 µM -1.26758547937722 0.0695773043612928 no 3110 0.102473010062029 4314 2994051
SGTC_18 0111-0177 500 nM -1.27040516370867 0.0691513318439397 no 3111 0.101970172427203 4416 721752
SGTC_1073 triclabendazole 3.09 µM -1.27290310636554 0.0687756463457753 no 3112 0.101526213415378 4376 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_3056 9094900 49.47 µM -1.27294755057324 0.0687689763050553 no 3113 0.101518327118634 4325 25236784
SGTC_2726 cimetidine 79.27 µM -1.27374712808622 0.0686490635250603 no 3114 0.101376524193927 4330 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_3050 9093513 49.47 µM -1.27690518031687 0.0681770256003545 no 3115 0.100817862516811 4315 25236664
SGTC_3267 9137951 49.47 µM -1.27859644085584 0.0679252630126388 no 3116 0.100519601980892 4400 16643986
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.27972916988597 0.0677570457769164 no 3117 0.100320200989276 4306 6708739 YPR165W RHO1
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.28066612703758 0.0676181451936908 no 3118 0.100155481158981 4346 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_450 aminopyrene 156 nM -1.28772240728183 0.066579133635552 no 3119 0.0989213053443648 4305 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3099 9120367 49.47 µM -1.29373110599727 0.0657041538072916 no 3120 0.0978791584637176 4400 24824940
SGTC_2280 7785178 200 µM -1.29536885369876 0.0654672195924739 no 3121 0.0975965085885928 4353 2954328
SGTC_2644 guaiazulene 100 µM -1.30420156794943 0.0642007906838507 no 3122 0.0960824327158618 4387 3515 A coloring agent.
SGTC_511 blebbistatin 171 µM -1.30641186132978 0.0638868783944839 no 3123 0.0957062671664752 4425 3476986 A myosin inhibitor.
SGTC_2617 dihydrotanshinone i 20.83 µM -1.3071783437904 0.0637782995156114 no 3124 0.0955760743468165 4331 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1482 3346-2049 8.48 µM -1.3120108454666 0.0630970361079767 no 3125 0.0947582376174245 4394 3826804
SGTC_836 0330-0104 1.35 µM -1.31243077479534 0.0630381051078575 no 3126 0.0946874144495489 4397 46494820
SGTC_2626 ethyl orsellinate 100 µM -1.31422763945048 0.0627864252414792 no 3127 0.0943848049094381 4322 75653 A natural product.
SGTC_1868 st057644 42.7 µM -1.31434627953316 0.0627698353808394 no 3128 0.0943648498891337 4398 688665
SGTC_197 4544-0043 41.561 µM -1.31733552094372 0.0623529655056497 no 3129 0.0938630918412858 4390 896523
SGTC_742 0kpi-0133 140 µM -1.31790480889971 0.0622738197573998 no 3130 0.0937677578515823 4401 2728852
SGTC_595 3909-8003 73.7 µM -1.32065201809867 0.0618929875277842 no 3131 0.0933087098550887 4441 699517
SGTC_124 0136-0217 7.121 µM -1.32079680975374 0.0618729663033079 no 3132 0.0932845618728314 4442 3976905
SGTC_2189 6047310 154.431 µM -1.32105280020226 0.0618375813133058 no 3133 0.0932418797385418 4353 711535
SGTC_783 0848-0141 92.7 µM -1.32422885333085 0.0613998751499764 no 3134 0.0927135255059484 4309 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1442 4112-3290 3 µM -1.33112719148929 0.0604575235827625 no 3135 0.091573581607258 4381 704353
SGTC_1038 k292-0204 154 µM -1.33181547442119 0.0603641245952238 no 3136 0.0914604158617528 4336 4454212
SGTC_125 0133-0007 11.75 µM -1.3348044348261 0.059959836390779 no 3137 0.090970180819577 4471 26541
SGTC_1428 4049-0204 61.7 µM -1.33585831791874 0.0598177944054855 no 3138 0.0907977935753957 4427 X1428
SGTC_1306 1185-0270 9.02 µM -1.33898992444122 0.0593972726610528 no 3139 0.0902869764925323 4411 1548076
SGTC_2093 5331342 194.4 µM -1.34742537285868 0.0582760603141818 no 3140 0.0889216366950264 4444 33839
SGTC_1708 st033234 31.827 µM -1.35026845132828 0.0579019362272685 no 3141 0.0884649441215054 4492 674664
SGTC_2451 5856223 45.7 µM -1.35209067587159 0.0576631420669428 no 3142 0.0881731548745331 4391 2179896
SGTC_229 benomyl 22.8748 µM -1.35676334629818 0.0570543487315455 no 3143 0.0874282086940354 4424 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1327 1436-0082 2.18 µM -1.3597474010016 0.0566682170521838 no 3144 0.0869549362361134 4426 15992205
SGTC_226 1,3-diallylurea 8.28947 mM -1.36249003819573 0.0563151427932705 no 3145 0.0865216429361928 4371 74537 YKL182W FAS1
SGTC_718 1130-0073 349 µM -1.3715698198092 0.0551586159351941 no 3146 0.0850986972090436 4434 6740020
SGTC_3351 9150312 21.596 µM -1.37948942074073 0.0541652582080797 no 3147 0.0838719529120664 4329 4904905
SGTC_2085 5307070 144.047 µM -1.3798031900661 0.0541261955248117 no 3148 0.0838236250818414 4362 2840351
SGTC_2868 9035608 32.47 µM -1.38252472954496 0.0537883123879174 no 3149 0.0834053213545314 4396 6462614
SGTC_1762 st045503 25.4615 µM -1.38600316269604 0.0533588940076751 no 3150 0.0828729688779824 4477 4645554
SGTC_3146 9095609 49.47 µM -1.38780863144539 0.0531370794479152 no 3151 0.0825976628960901 4468 17173999
SGTC_74 000s-0487 160.283 µM -1.38918890081974 0.0529679972263456 no 3152 0.0823876579492985 4298 677548
SGTC_881 0833-0569 170 µM -1.3927014785826 0.0525396328093085 no 3153 0.0818550406576985 4449 5418700
SGTC_3274 9138298 49.47 µM -1.39274582004316 0.05253424292498 no 3154 0.0818483337229454 4406 17015756
SGTC_3161 9100388 49.47 µM -1.39384615634774 0.0524006331047437 no 3155 0.0816820333211284 4501 25236368
SGTC_887 0885-0007 9.62 µM -1.39552714629733 0.052197037681074 no 3156 0.0814284672803615 4461 5719458
SGTC_2428 5615643 7.78 µM -1.39686583925036 0.0520353498356332 no 3157 0.0812269594535822 4421 2253075
SGTC_589 1227-0070 34.1 µM -1.39733084219295 0.0519792798044534 no 3158 0.0811570526259043 4479 2841384
SGTC_997 3996-0078 137 µM -1.39856679719246 0.0518304817574341 no 3159 0.0809714644138897 4481 735687
SGTC_755 1995-0008 37.3 µM -1.3987785437177 0.0518050233491387 no 3160 0.080939701201637 4390 689533
SGTC_3324 9138759 60.749 µM -1.39928662206137 0.0517439773270236 no 3161 0.08086352485152 4464 45595710
SGTC_2012 4023501 200 µM -1.39998841935278 0.0516597498706497 no 3162 0.080758393188786 4429 3477460
SGTC_729 4092-0585 94.1 µM -1.40640459505983 0.0508947451661297 no 3163 0.0798020082909079 4444 2169061
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.4067393250864 0.0508550839554081 no 3164 0.0797523500951254 4517 688801
SGTC_2317 5986382 200 µM -1.40748647916133 0.0507666445535506 no 3165 0.0796415918834689 4462 877883
SGTC_1279 0874-0590 65.2 µM -1.41890090476166 0.0494307074787935 no 3166 0.0779639542499827 4505 3523074
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.4195336366523 0.0493574817728221 no 3167 0.0778717487822376 4435 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2023 5144124 124 µM -1.42390589577484 0.0488538467583459 no 3168 0.0772368574527083 4422 2830192
SGTC_679 0422-0091 41.4 µM -1.42540726279091 0.0486818564085147 no 3169 0.077019754930364 4484 627384 YHR062C RPP1
SGTC_2785 7756463 72.73 µM -1.42706302267706 0.0484927410480521 no 3170 0.0767808648403149 4425 2201551
SGTC_839 0122-0028 230 µM -1.43009360579431 0.048148119994164 no 3171 0.0763450775783146 4474 759448
SGTC_2030 5175110 200 µM -1.43011952590106 0.0481451809781041 no 3172 0.0763413584918583 4456 2831986
SGTC_1162 k048-0130 20.1 µM -1.43087627485371 0.0480594383644585 no 3173 0.0762328388774975 4432 6797406
SGTC_2661 dactinomycin 12.96 µM -1.43770653140206 0.0472910612854485 no 3174 0.0752586695645703 4432 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_3088 9117578 49.47 µM -1.44314450316971 0.0466863769343748 no 3175 0.0744898845317643 4524 678341
SGTC_572 0960-0087 17.7 µM -1.44423603407946 0.0465657531282703 no 3176 0.0743362959901677 4413 6796365
SGTC_922 1866-0035 480 µM -1.45275907537767 0.0456324611510756 no 3177 0.0731453291540217 4405 3156169
SGTC_3148 9097893 49.47 µM -1.48747893594588 0.0419848823936248 no 3178 0.0684441812364585 4452 17174100
SGTC_1192 1488-0095 21.4 µM -1.48947221815219 0.0417828525149378 no 3179 0.0681815319041582 4519 915875
SGTC_493 zm226600 134 µM -1.49422223603389 0.0413045852101419 no 3180 0.0675587712849618 4495 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2733 amorolfine 100 µM -1.49483594662164 0.04124311723787 no 3181 0.0674786311855796 4648 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1172 0370-0043 85 µM -1.49742218362211 0.040984899366436 no 3182 0.0671417198067888 4513 376585
SGTC_2611 pyromycin 23.93 µM -1.50068213892029 0.0406612851578071 no 3183 0.0667188974671414 4444 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_830 4076-0286 57.8 µM -1.50260069845483 0.0404718020688105 no 3184 0.0664710215900867 4542 6866659
SGTC_221 trifluoperazine 10.304 µM -1.50292385786679 0.0404399564673309 no 3185 0.0664293399820645 4477 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2863 9028737 58.44 µM -1.51263153323447 0.0394927652976439 no 3186 0.0651866398663701 4490 6460917
SGTC_1023 4482-3888 16 µM -1.51350350515738 0.0394085764877648 no 3187 0.0650759057396066 4504 3303168
SGTC_19 0279-0214 38.434 µM -1.51966517353067 0.0388178210291436 no 3188 0.0642975743735827 4571 3566274 YBR002C RER2
SGTC_2315 7733312 200 µM -1.52003852462158 0.0387822586860169 no 3189 0.0642506467780999 4412 726316
SGTC_1774 st048371 48.465 µM -1.52053235157774 0.0387352615766978 no 3190 0.0641886171131143 4502 4242727
SGTC_3355 9151058 44.0485 µM -1.52374562087682 0.0384305893338761 no 3191 0.0637861341945072 4527 17015728
SGTC_1444 4112-3581 28 µM -1.52811163509004 0.0380197505205481 no 3192 0.0632424115753225 4589 2877249
SGTC_1353 1498-1206 8.11 µM -1.53061274809914 0.0377860163192483 no 3193 0.0629325645916157 4531 6756808
SGTC_2111 5486399 200 µM -1.53437908434099 0.037436258317341 no 3194 0.0624682100373405 4478 689674
SGTC_2210 7115885 190.385 µM -1.5363400272985 0.0372552061780168 no 3195 0.0622275036360902 4593 2927039
SGTC_204 PMA1.184 62.41 µM -1.54901692880963 0.0361019503535481 no 3196 0.0606888253045114 4493 2252213 YGL008C PMA1
SGTC_1115 galangin 695.678 nM -1.56064341463964 0.0350701133256725 no 3197 0.0593039546075824 4589 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1727 st034309 9.9045 µM -1.56987766690651 0.0342679366540963 no 3198 0.0582217870998212 4547 870305
SGTC_3317 9138495 8.753 µM -1.5733455712703 0.0339706030630085 no 3199 0.0578194113216663 4455 17020139
SGTC_1408 3909-7976 48.8 µM -1.57944923141 0.0334524382012172 no 3200 0.0571165263302282 4569 24152374
SGTC_3235 9132602 49.47 µM -1.58074915057646 0.0333429274540101 no 3201 0.0569677026565035 4517 4912240
SGTC_1519 esterone 74 µM -1.58476532639202 0.0330064512819755 no 3202 0.0565098315674525 4529 698 A steroid.
SGTC_479 n-linoleoylglycine 10 µM -1.58679235832687 0.0328376915043963 no 3203 0.0562798400658383 4574 6433346 An anti-infammatory.
SGTC_1337 1486-1011 40.3 µM -1.58814059516427 0.0327258389284308 no 3204 0.0561272752319476 4536 X1337
SGTC_624 k048-0052 28 µM -1.6027014007452 0.0315377428667764 no 3205 0.0545002970670819 4541 6835531
SGTC_2274 7947094 46.08 µM -1.61251946325038 0.0307569338381742 no 3206 0.0534244740328427 4514 2971028
SGTC_2113 5491891 107.031 µM -1.61888555971136 0.0302592569971738 no 3207 0.0527359442025194 4543 789979
SGTC_2330 7979373 200 µM -1.61943138318341 0.0302168990617899 no 3208 0.0526772394890448 4488 1863007
SGTC_1265 0819-1001 68.8 µM -1.62342408561303 0.0299085428839119 no 3209 0.0522493896968393 4498 3106768
SGTC_486 niguldipine 82 µM -1.62627490652039 0.0296899748925079 no 3210 0.0519455937194108 4630 1236 A calcium channel blocker.
SGTC_3289 9119912 71.43 µM -1.62966757361881 0.029431593295264 no 3211 0.0515858871102031 4555 17014829
SGTC_2508 celastrol 40.54 µM -1.63387832905842 0.0291135062475057 no 3212 0.0511422004634621 4495 122724 Celastrol is a natural product and antioxidant.
SGTC_858 0438-0351 2.77 µM -1.64111375235711 0.0285736033925324 no 3213 0.0503869022642035 4549 2799119
SGTC_223 busulfan 5 mM -1.64234275183818 0.0284827288345836 no 3214 0.050259495933437 4554 2478 A DNA alkylator.
SGTC_2801 7907800 81.82 µM -1.65310964775823 0.0276968388886227 no 3215 0.0491542750935787 4542 6620925
SGTC_670 4204-0025 119 µM -1.65440248739801 0.0276036997408165 no 3216 0.0490228807087984 4586 719039
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.65540432435972 0.0275317047641614 no 3217 0.0489212547041501 4598 94937 An inhibitor of serotonin biosynthesis.
SGTC_472 calcifediol 10 µM -1.65625010443614 0.027471046425622 no 3218 0.0488355901611881 4600 5283731 A vitamin D metabolite.
SGTC_163 TUB2.036 7.546 µM -1.65860553490487 0.0273027047802765 no 3219 0.0485976528689486 4522 15992207 YJR013W GPI14
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.66139005774911 0.0271048067950003 no 3220 0.048317566644806 4654 4620898
SGTC_1335 1486-0900 202 µM -1.67884979556478 0.0258910341430156 no 3221 0.0465906605156339 4583 X1335
SGTC_2627 acetyl isogambogic acid 100 µM -1.68175638993248 0.0256934556495017 no 3222 0.0463080441947055 4584 6857789 A caspase activator and apoptosis inducer.
SGTC_696 1560-0013 611 µM -1.68326917171057 0.0255911232596771 no 3223 0.0461614977386047 4606 1650269
SGTC_684 1140-0066 328 µM -1.69426989894264 0.0248571941948726 no 3224 0.0451070038601944 4591 6813534
SGTC_2630 antimycin a 100 µM -1.69829345934689 0.0245932030855877 no 3225 0.0447261942924445 4519 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2758 dehydroepiandrosterone 69.35 µM -1.70466965435377 0.0241796729069477 no 3226 0.0441280262407687 4558 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_824 1304-0008 100 µM -1.70602933212334 0.0240922502318266 no 3227 0.0440013092496749 4602 768245
SGTC_2296 7971656 126.45 µM -1.70610464741954 0.0240874154853154 no 3228 0.0439942987257956 4581 666570
SGTC_1770 st043884 66.3 µM -1.70787715503886 0.0239738672675642 no 3229 0.0438295694611564 4605 670149
SGTC_2024 5144227 134 µM -1.70911934195809 0.0238945601600832 no 3230 0.0437144227335474 4571 3475211
SGTC_818 4072-2707 53.5 µM -1.71246483110775 0.023682064211053 no 3231 0.0434055202071334 4532 882871
SGTC_641 4092-0595 30 µM -1.72031844564713 0.0231894619972168 no 3232 0.0426872861538271 4636 786260
SGTC_1328 1441-0025 69.2 µM -1.72164231482072 0.0231072805093014 no 3233 0.042567166447821 4627 4562601
SGTC_1841 st054148 70 µM -1.72206074950913 0.0230813565065085 no 3234 0.042529257167392 4613 675442
SGTC_1247 0448-0043 5.84 µM -1.72255227055944 0.023050935744638 no 3235 0.0424847612964643 4564 3089013 YGL099W LSG1
SGTC_1747 st037496 66.6 µM -1.72493418870652 0.0229039941585425 no 3236 0.0422696666906978 4561 723305
SGTC_1437 4092-1038 11.6 µM -1.72660564768476 0.0228013529342086 no 3237 0.0421192554788668 4655 3977136
SGTC_1653 st012112 65 µM -1.72665569616458 0.022798285535304 no 3238 0.0421147584053288 4572 720429
SGTC_1961 st076550 68.7 µM -1.73452952244476 0.0223200215283162 no 3239 0.0414120861044671 4600 1579337
SGTC_2939 9044578 71.43 µM -1.73575386891777 0.0222464192781288 no 3240 0.0413036820241567 4537 2653634
SGTC_1094 duloxetine 25.4 µM -1.7444092000387 0.0217319185854278 no 3241 0.0405438809549177 4613 60834 A selective serotonin reuptake inhibitor.
SGTC_1521 st012942 49.4 µM -1.75475919152124 0.0211299134438545 no 3242 0.0396502532841828 4542 24207259
SGTC_2106 5357045 167.29 µM -1.75593854227785 0.0210622207685252 no 3243 0.0395494514930225 4629 668842
SGTC_2351 9026858 72.31 µM -1.77330441345571 0.0200865052551489 no 3244 0.0380891390690778 4520 1409300
SGTC_3011 9081274 71.4286 µM -1.77480112172113 0.0200042356603101 no 3245 0.0379653655369382 4622 6625322
SGTC_654 1124-0271 80.9 µM -1.77848941968678 0.0198027202258445 no 3246 0.0376617540578069 4623 5403748
SGTC_1280 0880-0253 10.1 µM -1.78698003792628 0.0193453629997187 no 3247 0.0369703574998239 4622 6836607
SGTC_843 0310-0051 143 µM -1.7877504304319 0.0193043126470311 no 3248 0.0369081407400353 4637 2065037
SGTC_1839 st053978 48 µM -1.78986022005183 0.0191922713087868 no 3249 0.0367381926318834 4643 3788398
SGTC_1260 0700-1617 7.75 µM -1.79218125205899 0.0190696508859131 no 3250 0.0365519683953609 4588 2853078
SGTC_1200 1643-0193 18.4 µM -1.79471364797089 0.0189366246280081 no 3251 0.0363496674705956 4643 5403974
SGTC_421 streptovitacin 30 mM -1.79519389145084 0.0189114867730941 no 3252 0.0363114066965254 4596 91467 include heat shock
SGTC_485 niflumic acid 177 µM -1.80465092633824 0.018422221159269 no 3253 0.0355646617796679 4656 4488 A COX2 inhibitor.
SGTC_2311 7694451 200 µM -1.81702209038763 0.0177985011598333 no 3254 0.0346068654709619 4617 2163142
SGTC_2053 5265679 138 µM -1.82425643670387 0.0174421811107693 no 3255 0.0340566565099446 4546 764595
SGTC_1723 st034307 2.5525 µM -1.82908784835944 0.017207622362947 no 3256 0.0336932245302193 4623 867466
SGTC_648 0375-0473 33.3 µM -1.82953120616554 0.0171862335555668 no 3257 0.0336600344200361 4623 1713139
SGTC_2478 5763493 32.33 µM -1.83824247641208 0.0167705631335831 no 3258 0.0330133416281261 4590 1365576 YLR208W SEC13
SGTC_2421 5690543 90.72 µM -1.84120445052878 0.0166312014899823 no 3259 0.0327958017059753 4625 3397993
SGTC_1709 st033179 39.1045 µM -1.84522774795657 0.0164434923949351 no 3260 0.0325022078439646 4648 573381
SGTC_2178 5812956 200 µM -1.84526941006 0.016441558154939 no 3261 0.0324991789963171 4621 5403383
SGTC_2789 5281112 71.43 µM -1.85193647824827 0.0161345266226409 no 3262 0.0320174724943098 4646 765948
SGTC_1838 st055369 84.5 µM -1.85984550132319 0.0157766835834008 no 3263 0.0314536938484085 4623 676036
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -1.86709359164204 0.0154547434729356 no 3264 0.0309442595901224 4577 5355888
SGTC_1522 st012842 45.6 µM -1.86948893829299 0.0153495961334847 no 3265 0.030777410596152 4495 3491067 YOR116C RPO31
SGTC_370 0180-0345 38.7 µM -1.87361862903625 0.015169759432845 no 3266 0.0304915042588519 4528 3989527
SGTC_1964 st076914 61 µM -1.87422257475291 0.0151436115723864 no 3267 0.0304498769416742 4673 24208661
SGTC_303 1348-1668 34.2 µM -1.87955818356525 0.0149142836944095 no 3268 0.0300841584147477 4675 5380509
SGTC_3005 9076496 71.4286 µM -1.88093373171485 0.0148556481265678 no 3269 0.0299904669755628 4627 21368410
SGTC_3189 9110682 49.47 µM -1.89352157577867 0.0143282110059592 no 3270 0.0291442708658133 4643 17122418
SGTC_1219 1469-0211 33.1 µM -1.89412823180506 0.0143032043694937 no 3271 0.0291039956182577 4659 6822282
SGTC_3335 9143315 29.6265 µM -1.90454320231423 0.0138797203193439 no 3272 0.0284197378569573 4670 4899691
SGTC_2007 4011539 71.82 µM -1.91140611769003 0.0136066143452655 no 3273 0.0279762055656842 4639 45595301
SGTC_709 3807-1509 243 µM -1.91348776845787 0.013524698237577 no 3274 0.0278428189511157 4712 1886677 YPL242C IQG1
SGTC_380 3970-0968 6 µM -1.92272582808283 0.0131662829863756 no 3275 0.0272572456940788 4594 2891601
SGTC_1965 Pectolinarigenin 58.4 µM -1.92293121686694 0.0131584085497889 no 3276 0.0272443443512783 4660 5320438 An anti-inflammatory.
SGTC_3135 9127742 49.47 µM -1.92369128457113 0.0131293035668723 no 3277 0.0271966455645564 4696 3643468
SGTC_375 3970-0961 9.27 µM -1.9403749181705 0.0125043125114951 no 3278 0.0261670712581349 4647 2898222
SGTC_1309 pyrazolanthrone 13.4 µM -1.96368660638067 0.0116742540498927 no 3279 0.0247832233931782 4692 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2869 9037858 32.47 µM -1.97086779321729 0.0114283841546356 no 3280 0.0243694999290744 4643 27187042
SGTC_2552 juarezic acid 87.02 µM -1.97260074719578 0.0113697293833986 no 3281 0.0242705339104128 4645 1549512
SGTC_731 3966-0296 387 µM -1.97315414226432 0.0113510539722305 no 3282 0.0242390016565586 4692 660956
SGTC_2838 9002687 71.43 µM -1.98563432427938 0.0109369077369318 no 3283 0.0235369711464549 4663 6457060
SGTC_1685 st024049 53.0905 µM -1.99392278653236 0.0106691824476407 no 3284 0.0230802466648142 4711 1941139
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.99512771209296 0.0106307412615388 no 3285 0.0230144763081329 4702 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3122 9126309 49.47 µM -1.99925108156686 0.0105001032222339 no 3286 0.0227905970719543 4734 17591206
SGTC_1638 st008370 60.6 µM -2.00233934221586 0.0104031782061294 no 3287 0.0226241237222282 4646 24207134
SGTC_542 3381-0244 89.3 µM -2.01142998717206 0.0101223811959547 no 3288 0.0221400292879018 4690 1112843
SGTC_275 trichlorophene 5.69 µM -2.02138435667056 0.00982251156437232 no 3289 0.0216199963962269 4708 62616
SGTC_1945 st075991 56.6 µM -2.0224644479576 0.00979044578655153 no 3290 0.0215641964272092 4674 1084980
SGTC_2173 5763948 167 µM -2.02343931625972 0.0097615824178603 no 3291 0.0215139370662313 4674 2867177
SGTC_3008 9078912 71.4286 µM -2.07814187211358 0.00825661551814675 no 3292 0.0188481470182578 4692 16648731
SGTC_1063 disulfiram 1.84 µM -2.08559750706236 0.00806815061170398 no 3293 0.0185075486827446 4710 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2833 9001315 45.46 µM -2.09459691085247 0.00784570679126094 no 3294 0.0181034200314553 4641 2989378
SGTC_371 0195-0006 7.36 µM -2.10507640629636 0.00759349282027138 no 3295 0.0176423288182933 4581 3928593
SGTC_782 0083-0095 30.5 µM -2.11655664397925 0.00732541387222404 no 3296 0.0171487465172636 4699 3591729 An indicator and reagent.
SGTC_2378 9074213 121.43 µM -2.12545262649113 0.00712345350463568 no 3297 0.0167744315046413 4704 657714
SGTC_2252 omeprazole 400 µM -2.12739767440158 0.00707995629647555 no 3298 0.0166935276111532 4748 4594 A proton pump inhibitor.
SGTC_1654 st012436 41.8 µM -2.13272700923331 0.00696197463999975 no 3299 0.0164735634619277 4732 4323132
SGTC_2460 5552655 174.22 µM -2.14524357662963 0.00669168163983285 no 3300 0.0159666885757105 4687 5401989
SGTC_372 0155-0182 15.9 µM -2.14931399560938 0.00660580251516891 no 3301 0.0158047589092342 4602 771486
SGTC_2091 4-phenylthiadiazole 200 µM -2.14988822820023 0.00659376591944864 no 3302 0.0157820285016065 4729 270010
SGTC_2713 st079149 53.4 µM -2.16789331441405 0.00622606330080801 no 3303 0.0150834023280232 4725 3103253
SGTC_258 haloperidol 50.781 µM -2.16916862577504 0.00620072099454145 no 3304 0.0150349420687294 4716 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_545 4218-0007 221 µM -2.16972453073791 0.00618970296947853 no 3305 0.0150138602786992 4716 2840508
SGTC_2558 carylophyllene oxide 100 µM -2.19157986435573 0.00577004581002518 no 3306 0.0142049285929854 4759 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2174 5790901 200 µM -2.19969688406633 0.00562073736445198 no 3307 0.0139142040137808 4698 786020
SGTC_2242 6630449 61.2675 µM -2.20544097864571 0.00551716075253939 no 3308 0.0137115825781081 4700 691249 YDR170C SEC7
SGTC_2289 7946404 165.07 µM -2.2073778544684 0.00548261959043855 no 3309 0.0136438361072328 4700 1246120 YPR165W RHO1
SGTC_1947 st076332 61.6 µM -2.20821510359731 0.00546774813753897 no 3310 0.0136146410154706 4630 24208416
SGTC_2424 5537928 59.2 µM -2.21843864049306 0.00528902511856901 no 3311 0.0132624694690641 4725 5382802
SGTC_1245 0418-0076 17.2 µM -2.2274833251752 0.00513526194343455 no 3312 0.0129574945097955 4711 6790114
SGTC_516 3992-2719 87.3 µM -2.26777044180014 0.00449763098650311 no 3313 0.011671600932269 4665 5350887 YDR037W KRS1
SGTC_3356 9151811 4.48 µM -2.26829866602999 0.00448976258546591 no 3314 0.0116555045906523 4755 1859254 YPR165W RHO1
SGTC_1667 st014849 34.6 µM -2.26957160070222 0.00447085150011704 no 3315 0.0116167941748339 4787 5348460
SGTC_899 1083-0020 478 µM -2.29325308351468 0.00413176885137358 no 3316 0.0109167193054498 4756 767123
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -2.29463397851152 0.00411272594127892 no 3317 0.0108770546515923 4727 6708561
SGTC_2104 5389443 200 µM -2.32244213112903 0.0037455953445972 no 3318 0.0101045705006977 4746 2244536
SGTC_920 mycophenolic acid 780.421 nM -2.3643418633155 0.00324777495507421 no 3319 0.00903106831766885 4730 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1307 1187-1599 12.2 µM -2.37907880874971 0.00308736698674564 no 3320 0.0086779824517782 4763 1538471
SGTC_1837 st055472 66.5 µM -2.38552871222855 0.00301943366526192 no 3321 0.00852729551586387 4761 676091
SGTC_1714 st033236 13.627 µM -2.39496489394817 0.00292247246854078 no 3322 0.0083109783347144 4736 2916566
SGTC_2026 5148700 152 µM -2.39632069927357 0.00290877397542096 no 3323 0.00828029681473898 4750 79838
SGTC_1316 1272-0050 65.9 µM -2.42050661911937 0.00267394254326447 no 3324 0.00774944856173689 4758 7340392
SGTC_2588 indole-3-carbinol 100 µM -2.42254667902948 0.0026549399000924 no 3325 0.00770607278661979 4735 3712 Induces cell cycle arrest.
SGTC_1198 1612-1005 86.7 µM -2.45609538656442 0.00235945289966776 no 3326 0.00702279351863272 4760 6998509
SGTC_77 0828-0286 12.516 µM -2.47071998194502 0.0022402261698811 no 3327 0.00674206784858517 4693 745345
SGTC_2286 7945697 125 µM -2.47944862173791 0.00217169431038181 no 3328 0.00657928429646681 4718 1245733
SGTC_2556 citropten 84.59 µM -2.48100167275514 0.00215970181505572 no 3329 0.00655068791272127 4731 2775 A potential DNA crosslinker.
SGTC_1409 3909-8004 61.9 µM -2.58348010319412 0.00148920305314809 no 3330 0.00489045542830689 4787 2119279
SGTC_1319 1306-0155 43.7 µM -2.61609946904623 0.00131955410436845 no 3331 0.00444703218094506 4775 3122360
SGTC_904 1141-0088 396 µM -2.62326849153927 0.00128472174487288 no 3332 0.0043545305260966 4765 1378119
SGTC_196 k015-0023 18.111 µM -2.63024994537323 0.00125161082522611 no 3333 0.00426610559884216 4769 5211998
SGTC_1300 1094-0077 113 µM -2.6705623558087 0.00107521788720698 no 3334 0.00378621526349934 4782 5532636
SGTC_914 3820-6779 408 µM -2.69405592836792 0.000983239023316087 yes 3335 0.00352941594633749 4734 2893481
SGTC_2087 5276107 200 µM -2.70314243094844 0.000949644846801712 yes 3336 0.00343436531874568 4776 144405
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -2.72881519803755 0.000860343646050958 yes 3337 0.00317811566732766 4788 688664
SGTC_2238 6671620 73.2395 µM -2.73923666414748 0.000826349637282745 yes 3338 0.00307910130850434 4730 729941
SGTC_1960 st011366 51.8 µM -2.77169040571229 0.000728247560514406 yes 3339 0.00278830236218745 4790 3972846
SGTC_1168 k815-0004 80.5 µM -2.80906250217694 0.000628631697202318 yes 3340 0.00248429996985405 4780 642433
SGTC_1436 4092-1007 8.32 µM -2.80955929223413 0.000627396612659199 yes 3341 0.00248046901073029 4789 2881121
SGTC_2241 6772625 37.8075 µM -2.81069796504247 0.000624574172681386 yes 3342 0.00247170837000343 4677 2285411
SGTC_1160 4092-0570 10.5 µM -2.84088201067029 0.00055389879488052 yes 3343 0.00224944770717081 4777 4994975
SGTC_2476 5806916 10.51 µM -3.00911148648032 0.000277985316957659 yes 3344 0.00131006475041847 4778 2870194
SGTC_2555 cholic acid 100 µM -3.00945233281919 0.000277587668296136 yes 3345 0.00130859571727846 4775 6708657 Influences liver metabolism.
SGTC_3113 9123498 49.47 µM -3.13502127250208 0.000162259938196321 yes 3346 0.000859208249997351 4804 8897275
SGTC_1944 st076371 56.9 µM -3.16625829044899 0.00014155091442853 yes 3347 0.000772068080276726 4789 24208455
SGTC_785 1270-0111 65.3 µM -3.17971626584826 0.000133415469247736 yes 3348 0.000737096597964925 4778 6741994
SGTC_2662 daunorubicin 22.37 µM -3.19721285318291 0.000123493052224233 yes 3349 0.000693812453459321 4717 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2600 tangeritin 87.95 µM -3.24613528470151 9.92971614223498e-05 yes 3350 0.000584916169695056 4779 68077 A bioactive flavone.
SGTC_2512 diallyl trisulfide 49.23 µM -3.28939347928727 8.16850155918311e-05 yes 3351 0.000502017764227097 4802 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1302 1159-0335 255 µM -3.4589977807481 3.71641812108914e-05 yes 3352 0.000271094686006021 4802 649284
SGTC_1020 4335-0961 93.3 µM -3.69474674256612 1.17308963341228e-05 yes 3353 0.000110053031069091 4792 669075
SGTC_1665 st014639 11.4 µM -3.79855657372646 6.90897037677555e-06 yes 3354 7.27706054615487e-05 4810 981133 YIL048W NEO1
SGTC_708 3448-5400 146 µM -3.81777688314708 6.25478417939229e-06 yes 3355 6.73298106708179e-05 4799 3462195
SGTC_2339 9000433 200 µM -4.95506447958351 7.69544824752634e-09 yes 3356 3.61531535267106e-07 4805 2988954