SGTCid condition conc unit TSC3|YBR058C-A.score TSC3|YBR058C-A.strain.pval TSC3|YBR058C-A.strain.significant TSC3|YBR058C-A.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2110 5483698 200 µM 62.4105728547954 8.08890321464457e-279 yes 1 0 1 2848765 YHR062C RPP1
SGTC_1603 st002045 67.8 µM 53.7236537747517 4.61412536331666e-207 yes 2 0 1 5887985
SGTC_3236 9132701 49.47 µM 53.0233333490466 9.57010106276029e-202 yes 3 0 1 24282524
SGTC_1604 st002052 72.4 µM 51.6743925917691 1.05998596983208e-191 yes 4 0 1 6254834 YHR062C RPP1
SGTC_1919 st067113 52.3 µM 51.4476366959267 4.8788972369836e-190 yes 5 0 1 1268243
SGTC_52 0329-0193 875 nM 51.0559894379077 3.49472993457743e-187 yes 6 0 1 3739292
SGTC_885 0865-0106 16.8 µM 45.9132463674826 1.01905071999779e-151 yes 7 0 1 2793380
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 44.6265273143837 1.96253735484547e-143 yes 8 0 1 756377
SGTC_16 erodoxin 22.806 µM 40.4743339724059 2.63216293152642e-118 yes 9 0 1 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2111 5486399 200 µM 40.0547943717264 6.6492481497907e-116 yes 10 0 1 689674
SGTC_2090 5301565 104.445 µM 38.6568721517207 4.43780765189579e-108 yes 11 0 1 2056344
SGTC_1173 0443-0020 122 µM 37.9424889350762 3.45442117911809e-104 yes 12 0 1 5331295
SGTC_3317 9138495 8.753 µM 37.6113206207214 2.07782873615376e-102 yes 13 0 1 17020139
SGTC_897 1000-0139 31.4 µM 37.6004821668638 2.3745254905081e-102 yes 14 0 1 6151020
SGTC_2225 6654152 15.4 µM 36.8991273736112 1.23339732164484e-98 yes 15 2.38618938502203e-298 1 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2627 acetyl isogambogic acid 100 µM 35.4313141590769 4.3720462823486e-91 yes 16 2.813866504985e-275 1 6857789 A caspase activator and apoptosis inducer.
SGTC_2405 ticlatone 3.52 µM 34.6128668632665 5.21538619186509e-87 yes 17 8.08981800758395e-263 1 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1299 1079-1439 3.74 µM 33.9490599792384 8.98886103935791e-84 yes 18 6.29670396469631e-253 1 323161
SGTC_210 3551-0445 56.827 µM 33.6086025584257 3.88435656740496e-82 yes 19 6.28028985623454e-248 2 2865180 YOR207C RET1
SGTC_46 0329-0187a 2.197 µM 33.3912152874668 4.21760354090958e-81 yes 20 9.19437912780936e-245 2 46494817
SGTC_790 1575-0012 79.1 µM 32.3176407170512 4.38177941654295e-76 yes 21 1.97689729277523e-229 1 378741 YLR208W SEC13
SGTC_1568 digitonin 820 nM 32.2854820320983 6.1573597431782e-76 yes 22 5.5917819173668e-229 2 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_28 pentachloropyridine N-oxide 1.606 µM 31.8257915898808 7.67801077683779e-74 yes 23 1.42359459096332e-222 1 140250 A respiratory chain inhibitor.
SGTC_985 1493-0307 8.71 µM 31.0411729052233 2.47274505670166e-70 yes 24 7.50480805362594e-212 1 3278274
SGTC_2112 5488546 200 µM 30.8891779760754 1.15509190401593e-69 yes 25 8.34632857606346e-210 1 600757
SGTC_428 3448-4153 16.5 µM 30.7853938735092 3.29481709492556e-69 yes 26 2.05531703532525e-208 1 3834874
SGTC_1726 st035556 14.5795 µM 30.3849065342354 1.82008841859485e-67 yes 27 4.34722011316806e-203 1 5919439
SGTC_3282 9108498 15.4605 µM 30.257731591289 6.43549756986568e-67 yes 28 2.06403663148852e-201 1 16459645
SGTC_2344 7990960 76.95 µM 29.486813997302 1.21417974877812e-63 yes 29 2.12468670370602e-191 1 140813
SGTC_1643 st009866 20.2 µM 28.6969511319354 2.25394223566599e-60 yes 30 2.08227206625315e-181 1 3156273 YOR207C RET1
SGTC_2323 6148992 148.28 µM 27.7391871153759 1.57611671112623e-56 yes 31 1.17650684615558e-169 1 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2949 9072542 2.23 µM 27.6255009717709 4.41875095405066e-56 yes 32 2.74878710782112e-168 1 16457352
SGTC_2701 st077767 14.721 µM 27.4903186819465 1.49719212680991e-55 yes 33 1.14593797652218e-166 1 5721188
SGTC_90 0870-0863 4.608 µM 27.1434846053646 3.33552930365277e-54 yes 34 1.51131257486156e-162 1 1738164
SGTC_59 0330-0160 1.33 µM 26.9863455364233 1.34346930688662e-53 yes 35 1.06881886524538e-160 1 4293482
SGTC_926 2268-1401 59.4 µM 26.7022274747381 1.63427853486609e-52 yes 36 2.21732252799504e-157 1 2931578
SGTC_1635 st007035 42.4 µM 26.6931418998949 1.76944269832702e-52 yes 37 2.82696465740414e-157 9 3716403
SGTC_1042 0350-0096 82 µM 26.3716499204656 2.89362948092765e-51 yes 38 1.44903614526055e-153 1 3122515
SGTC_2499 avocadenofuran 51.48 µM 26.3327663015025 4.04791362158298e-51 yes 39 4.04321085942571e-153 1 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2092 5303694 80.6725 µM 26.2285650982172 9.92796554338791e-51 yes 40 6.27695244530456e-152 1 1963699
SGTC_513 4245-1575 41.7 µM 26.1970852122366 1.30096851623628e-50 yes 41 1.43429537624583e-151 1 719745
SGTC_1634 st006576 41 µM 26.0351592321772 5.19947763196096e-50 yes 42 9.90608778235853e-150 1 3915356
SGTC_2218 6965428 192.983 µM 25.4207141649781 9.23222513575096e-48 yes 43 7.44296685096129e-143 1 675684
SGTC_77 0828-0286 12.516 µM 25.378103711364 1.31615755747984e-47 yes 44 2.20039576720454e-142 1 745345
SGTC_2077 5212015 200 µM 24.8270778981353 1.22351945537049e-45 yes 45 2.28687186970451e-136 1 780900
SGTC_1815 st051655 58.2 µM 24.3988630851525 3.86802413070747e-44 yes 46 8.79184393168249e-132 1 5984156
SGTC_1132 3456-3614 2.5 µM 23.9861282908218 1.01985497180182e-42 yes 47 1.94057976956147e-127 1 3125502
SGTC_275 trichlorophene 5.69 µM 23.9303506258076 1.58026102123072e-42 yes 48 7.40119528933144e-127 3 62616
SGTC_32 0928-0142 34.1 µM 23.7427514165467 6.84175217529945e-42 yes 49 6.52755377638442e-125 1 2244242
SGTC_548 1436-0017 110 µM 23.7405738566323 6.95865834959009e-42 yes 50 6.87452499269167e-125 1 9677137
SGTC_1891 st059073 26.2 µM 23.4693316847352 5.67311233839973e-41 yes 51 4.19618622692234e-122 1 688754
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 23.0453167028284 1.43713619956874e-39 yes 52 8.19443081570106e-118 2 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1013 4112-3890 241 µM 22.8872518603548 4.72326939599578e-39 yes 53 3.11211737582718e-116 1 705171
SGTC_2952 9073731 13.78 µM 22.6011776301049 3.98541189625739e-38 yes 54 2.10983903123102e-113 1 16457353
SGTC_1700 st030840 7.9285 µM 22.4381646074839 1.32763542289567e-37 yes 55 8.34979239886417e-112 2 5499307
SGTC_1239 0337-0584 35.4 µM 22.4376293189371 1.33287284049305e-37 yes 56 8.45088515545483e-112 5 914301 YML130C ERO1
SGTC_1332 1480-0653 17.5 µM 22.2532270006489 5.14534611304514e-37 yes 57 5.24811742378502e-110 1 5749438
SGTC_594 1487-1584 10.8 µM 22.2235218486119 6.38944265473248e-37 yes 58 1.01735796827369e-109 3 5013332
SGTC_2592 piperlongumine 83.33 µM 22.1470321102838 1.11444590964493e-36 yes 59 5.57108024157773e-109 1 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_134 0269-0018 6.916 µM 21.4803944159799 1.31092986211381e-34 yes 60 1.18740769627034e-102 5 4378915
SGTC_1813 st051246 8.6015 µM 21.4207002125303 1.99487008915319e-34 yes 61 4.28455531892029e-102 1 5291959
SGTC_955 1216-0110 33 µM 21.1524664759354 1.29719135391121e-33 yes 62 1.30942420020614e-99 3 3619719
SGTC_2526 patulin 37.61 µM 21.1145590538595 1.68690360105982e-33 yes 63 2.92264858581822e-99 2 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1030 k029-0042 36.7 µM 21.0717927164973 2.26754374731824e-33 yes 64 7.21806285947787e-99 1 6080581
SGTC_2552 juarezic acid 87.02 µM 20.9856617289035 4.10674708335677e-33 yes 65 4.43400892905212e-98 1 1549512
SGTC_235 0330-0087 5 mM 20.8874710526057 8.05889027209226e-33 yes 66 3.48045630804198e-97 1 46494818 YHR062C RPP1
SGTC_1738 st035555 74 µM 20.5552509242755 7.70449091837452e-32 yes 67 3.453611801697e-94 1 5331140
SGTC_2947 9072639 7.68 µM 20.1612461966314 1.06981665526966e-30 yes 68 1.07206667647096e-90 1 16488146
SGTC_328 k915-0120 63.5 µM 20.0768726780971 1.86692491140652e-30 yes 69 5.87835723085399e-90 1 6624543
SGTC_2416 tofa 880 nM 19.9366579692623 4.68554119310351e-30 yes 70 9.78556974933957e-89 4 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1222 0366-0074 1.18 µM 19.7514392247703 1.56458012484462e-29 yes 71 3.89820182357032e-87 1 286520
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 19.6792854905715 2.49501259535565e-29 yes 72 1.62272767110585e-86 2 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2980 9014342 25.29 µM 19.6746304860253 2.57112416446933e-29 yes 73 1.7788021256452e-86 1 2996599
SGTC_550 4123-0385 25.7 µM 19.4982966062189 7.983962819364e-29 yes 74 5.67498975858068e-85 1 5731123
SGTC_871 0574-0004 149 µM 19.4474993555925 1.10449247094189e-28 yes 75 1.52997038395945e-84 1 9551173
SGTC_1287 0971-0001 34.6 µM 19.2800874551576 3.19954633809289e-28 yes 76 3.94714642517065e-83 3 4665869
SGTC_1023 4482-3888 16 µM 18.8434547110118 4.91144664593818e-27 yes 77 1.66267662006051e-79 1 3303168
SGTC_2141 5621638 7.665 µM 18.7697858053374 7.73883446664896e-27 yes 78 6.67111625153886e-79 1 2856238
SGTC_1970 st070122 35.8 µM 18.7456517813675 8.97839923563251e-27 yes 79 1.05041019397836e-78 1 102928
SGTC_1978 st071761 42 µM 18.7199399327533 1.05159882280362e-26 yes 80 1.70267476320627e-78 1 5147680
SGTC_524 r073-0010 27.8 µM 18.7059802320747 1.14573361649226e-26 yes 81 2.21260270298568e-78 1 2772106
SGTC_2740 felodipine 17.08 µM 18.5704449429114 2.62515054957784e-26 yes 82 2.78695782019271e-77 1 3333 L-type calcium channel blocker
SGTC_2200 6600604 21.907 µM 18.4408143270592 5.76912070489968e-26 yes 83 3.09017065842348e-76 2 2904777
SGTC_315 k915-0449 187 µM 18.40267140225 7.26566892365416e-26 yes 84 6.25226616248641e-76 3 20970215 YNL149C PGA2
SGTC_266 formosanin C 406 nM 18.3058447383888 1.30204513809927e-25 yes 85 3.71650997132642e-75 5 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2113 5491891 107.031 µM 18.2629930077524 1.68393900537678e-25 yes 86 8.15502128879862e-75 1 789979
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 18.2494422069546 1.82639554401577e-25 yes 87 1.04516314176394e-74 2 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2151 5563267 85.4165 µM 18.1783191459424 2.794348144086e-25 yes 88 3.83236317230297e-74 1 5310824
SGTC_527 4476-4215 268 µM 17.9915808480219 8.46806872659752e-25 yes 89 1.13397338368464e-72 2 4418754
SGTC_1982 st072467 71.9 µM 17.857788052039 1.86097402575537e-24 yes 90 1.25703369154003e-71 1 3163533
SGTC_2567 aureobasidin a 60 nM 17.8498646364889 1.94945039556763e-24 yes 91 1.4486890869653e-71 3 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_720 r052-1644 49.9 µM 17.6823800762327 5.17880778024922e-24 yes 92 2.86621863220216e-70 1 1422863 YOR257W CDC31
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 17.6635696486445 5.77614549202002e-24 yes 93 4.00077254012129e-70 2 91467 include heat shock
SGTC_3060 1327-0027 12.5 µM 17.1374580447886 1.1678188395695e-22 yes 94 3.89931335737479e-66 1 16000455 YPR107C YTH1
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 17.048070475295 1.92903994210179e-22 yes 95 1.80631778785774e-65 1 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_589 1227-0070 34.1 µM 16.8522387908967 5.74016096086523e-22 yes 96 5.05085275116209e-64 1 2841384
SGTC_845 0330-0138 4.51 µM 16.7090802342556 1.26387481342522e-21 yes 97 5.62791289665663e-63 1 9039800
SGTC_575 k072-0246 11.9 µM 16.6659588239914 1.60098726489167e-21 yes 98 1.15871167639368e-62 2 6796779
SGTC_762 1165-0429 115 µM 16.6464329562966 1.78155007325788e-21 yes 99 1.60592421755655e-62 1 5967793
SGTC_439 amiodarone 34.4 µM 16.5740501038273 2.64467631677875e-21 yes 100 5.36728819226976e-62 2 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1888 azatryptophan 97.5 µM 16.4615757639675 4.86982156959501e-21 yes 101 3.46366777651165e-61 1 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_879 0831-1030 162 µM 16.3945061697961 6.99471733852684e-21 yes 102 1.04667445384054e-60 1 1549252
SGTC_2248 tofa 1.1 µM 16.2088967597347 1.8908640849273e-20 yes 103 2.18165538235913e-59 3 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1795 st049545 62.3 µM 16.2066091706197 1.9140485863161e-20 yes 104 2.26437935193767e-59 1 5291882
SGTC_212 3807-4682 38.772 µM 15.9872270294302 6.11077681458768e-20 yes 105 7.84297148482836e-58 2 3125501 YBL034C STU1
SGTC_1024 4507-0395 26 µM 15.7420699722061 2.19506878512852e-19 yes 106 3.89273128723105e-56 1 4201836
SGTC_1661 st013063 9.66 µM 15.5241265930625 6.73046397338706e-19 yes 107 1.19112789154287e-54 1 721395
SGTC_503 tyrphostin 8 294 µM 15.5122183369951 7.15219847655329e-19 yes 108 1.43398340248836e-54 1 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2071 5230951 39.92 µM 15.3852526005775 1.36337974739116e-18 yes 109 1.02786336285754e-53 1 1799272
SGTC_168 3970-0862 530.542 µM 15.356687035619 1.57521624689916e-18 yes 110 1.59744532528255e-53 2 3135186
SGTC_226 1,3-diallylurea 8.28947 mM 15.3214210083427 1.88199187509923e-18 yes 111 2.75008863014056e-53 1 74537 YKL182W FAS1
SGTC_1845 st056753 3.01 µM 15.1183399799251 5.20256740384943e-18 yes 112 6.12971077926283e-52 1 5375839
SGTC_47 0149-0135 24.25 µM 15.1029589025612 5.61600452074162e-18 yes 113 7.74134004875054e-52 1 5239155
SGTC_662 k832-1615 104 µM 14.9390784674529 1.26240801344673e-17 yes 114 9.17476092305095e-51 1 5878478
SGTC_1495 4469-0029 237 µM 14.6791383377495 4.48143709610766e-17 yes 115 4.38488901436604e-49 6 793680
SGTC_1617 st002906 78 µM 14.6372062148724 5.48637296173974e-17 yes 116 8.13070173866621e-49 3 5150859
SGTC_1925 st057770 10.1 µM 14.6241912411665 5.84127561423759e-17 yes 117 9.8448338582458e-49 1 5989122
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 14.5467107719965 8.47372652253436e-17 yes 118 3.06397382848573e-48 1 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 14.4611422393901 1.27504701032457e-16 yes 119 1.0661480716783e-47 1 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1119 parthenolide 318.541 nM 14.3518126125335 2.14168753195745e-16 yes 120 5.18943355323522e-47 1 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_878 0828-0289 13.7 µM 14.3162488804186 2.53313793904142e-16 yes 121 8.66120333872334e-47 1 745350 YLR208W SEC13
SGTC_883 0850-0245 24.6 µM 14.3056992869849 2.66225994778053e-16 yes 122 1.0080055452217e-46 1 6823229 YPR165W RHO1
SGTC_1001 4048-4355 44.4 µM 14.2988207012423 2.74992142408367e-16 yes 123 1.11274434302848e-46 1 21824233
SGTC_300 r073-0011 5.04 µM 14.1868368990602 4.64989110161518e-16 yes 124 5.52665252657766e-46 1 2735780
SGTC_612 0302-0167 22.4 µM 14.0824129365994 7.56097314635286e-16 yes 125 2.43587594918809e-45 3 235821
SGTC_1666 st014829 29 µM 14.0609422425456 8.35217269718102e-16 yes 126 3.30007726660971e-45 2 3858230
SGTC_664 1222-0054 14.9 µM 14.0595702929921 8.40541343556632e-16 yes 127 3.36467864059672e-45 4 6813991
SGTC_951 1171-0579 82.7 µM 14.0262579300864 9.8058274032472e-16 yes 128 5.38428121785967e-45 5 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 13.8993715191972 1.75781873800337e-15 yes 129 3.19499897862495e-44 1 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1401 3807-4679 7.6 µM 13.8959236796672 1.78579058283672e-15 yes 130 3.35264373775998e-44 1 3291456
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 13.7193823146237 3.98725002020482e-15 yes 131 3.88623651098492e-43 6 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_470 aa-861 153 µM 13.7093164650745 4.17283862543064e-15 yes 132 4.46475413963043e-43 4 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2265 7929201 200 µM 13.7079697889826 4.19830400799986e-15 yes 133 4.54838610439073e-43 1 1265108
SGTC_2581 avocatin a 64 µM 13.5931748493548 7.03680974497262e-15 yes 134 2.19795118972694e-42 1 6710728 A skin care supplement.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 13.5892852792676 7.16050063360856e-15 yes 135 2.31792608141222e-42 2 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_425 3825-7017 13.1 µM 13.5309924317546 9.29189096520323e-15 yes 136 5.13143461364938e-42 2 3397440
SGTC_1662 st014054 52 µM 13.3275710374626 2.28697042805343e-14 yes 137 8.00116981054089e-41 1 2838777
SGTC_1773 st048542 73.5835 µM 13.2651941359426 3.00636431744802e-14 yes 138 1.84232702278277e-40 3 3237138
SGTC_860 0443-0016 25.1 µM 13.258840870586 3.09107243201597e-14 yes 139 2.00523314068121e-40 1 5337942
SGTC_639 0833-0042 114 µM 13.0573790182573 7.41031617085381e-14 yes 140 2.88398093512177e-39 3 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1510 1123-0200 71.5 µM 13.0394858861977 8.00364308481271e-14 yes 141 3.6473634553745e-39 2 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1474 0330-0125 5.35 µM 13.0385970475257 8.03430317437844e-14 yes 142 3.69012952141879e-39 1 X1474
SGTC_1687 st020778 55.3625 µM 13.0310947797912 8.29773042348766e-14 yes 143 4.07154051605916e-39 28 4259299
SGTC_1711 st032263 62.8 µM 12.9906907191417 9.86919242554737e-14 yes 144 6.90871796788402e-39 1 3958979
SGTC_1706 st031321 9.9705 µM 12.9450520943891 1.19974012264632e-13 yes 145 1.25296596547979e-38 1 6103185
SGTC_858 0438-0351 2.77 µM 12.8680764556623 1.66518268850531e-13 yes 146 3.40382255166394e-38 1 2799119
SGTC_3062 9077494 49.47 µM 12.8135590298037 2.09795214619956e-13 yes 147 6.88360879044558e-38 2 16459633
SGTC_528 3492-0019 172 µM 12.7617593452515 2.6106090892028e-13 yes 148 1.34038560140967e-37 23 2869262
SGTC_1080 nisoldipine 24.4 µM 12.704376605664 3.32263664929223e-13 yes 149 2.79566025522786e-37 1 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_73 0327-0325 16.231 µM 12.6360617216051 4.42157635639049e-13 yes 150 6.67894117196478e-37 3 53298
SGTC_2585 alliin 100 µM 12.5737757224379 5.72994500987721e-13 yes 151 1.47162232604945e-36 1 87310 A garlic compound which reacts with lipids.
SGTC_922 1866-0035 480 µM 12.2668076198474 2.01846365301129e-12 yes 152 6.82654982444082e-35 4 3156169
SGTC_1941 st076221 61.8 µM 12.1266776486869 3.5504499439296e-12 yes 153 3.81409428721234e-34 10 2828568
SGTC_1608 st001473 40.5 µM 12.1094399325935 3.80420620090909e-12 yes 154 4.70673575406833e-34 2 7292267
SGTC_638 3970-0837 4.09 µM 12.0544361030366 4.73861657836684e-12 yes 155 9.18929955073388e-34 2 4118451 YLR208W SEC13
SGTC_2430 5571206 200 µM 11.9492425688497 7.19283711354836e-12 yes 156 3.27598202559163e-33 7 1731771
SGTC_3237 9133362 49.47 µM 11.9110973034337 8.360697986435e-12 yes 157 5.18023867083399e-33 3 43845137
SGTC_1573 oleylamine 1.06 µM 11.890889242979 9.05266146065445e-12 yes 158 6.5996852903622e-33 2 5356789 An amine of the fatty acid oleic acid.
SGTC_2408 sulbentine 18.36 µM 11.8205301782366 1.19280216529234e-11 yes 159 1.52874411893445e-32 3 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_12 0849-0099 9.267 µM 11.6233015902468 2.56260056650577e-11 yes 160 1.56885794817927e-31 1 6071388
SGTC_1279 0874-0590 65.2 µM 11.5775446201816 3.0546027757533e-11 yes 161 2.67790833186136e-31 1 3523074
SGTC_752 1896-0090 130 µM 11.5000690084965 4.106153173673e-11 yes 162 6.59050014653228e-31 1 772567
SGTC_1876 myriocin 605 nM 11.4488623891239 4.98761634651858e-11 yes 163 1.1912582010828e-30 4 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_505 gw-5074 63.9 µM 11.4125903896096 5.72133125117716e-11 yes 164 1.80895938701351e-30 11 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_236 1509-0011 5.31 µM 11.3158661344019 8.23269947828803e-11 yes 165 5.47576849297709e-30 166 3107280
SGTC_34 0469-0683 81.75 µM 11.3131303507772 8.31751310844698e-11 yes 166 5.6492613691002e-30 2 3690923
SGTC_177 1327-0068 8.361 µM 11.278786551419 9.45765496328013e-11 yes 167 8.35170250895193e-30 4 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2752 diclazuril 33.15 µM 11.211330032187 1.21586353429798e-10 yes 168 1.79380715662569e-29 19 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2161 5662504 8.5105 µM 11.0963894694095 1.85918976486808e-10 yes 169 6.53071801650255e-29 1 2859334
SGTC_1601 4'-hydroxyflavanone 55.5 µM 11.0738536511668 2.01962084704417e-10 yes 170 8.40082856980508e-29 1 165506
SGTC_806 3966-4455 5.86 µM 10.7129249857227 7.43595846017003e-10 yes 171 4.42599866922668e-27 1 714982
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 10.6052761940413 1.08807516531905e-09 yes 172 1.4081531702297e-26 4 368090
SGTC_3294 9122953 26.2835 µM 10.5612927522425 1.26982177642981e-09 yes 173 2.25207757331914e-26 2 16459826
SGTC_355 1311-2252 105 µM 10.4801482899792 1.68577264028005e-09 yes 174 5.32882501557221e-26 1 5338538
SGTC_1078 idebenone 36.1 µM 10.4204211297115 2.07391478072096e-09 yes 175 1.00032675691145e-25 3 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_488 nitrendipine 139 µM 10.3949767177491 2.26452871361696e-09 yes 176 1.30675382387428e-25 1 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_283 0987-0079 11.7 µM 10.3941394804793 2.27108206187293e-09 yes 177 1.31828005157227e-25 1 411556
SGTC_2043 5101342 149 µM 10.2821846327387 3.335591102779e-09 yes 178 4.23918425560473e-25 2 678451
SGTC_1511 0906-3109 28.5 µM 10.2410849815586 3.83725906510075e-09 yes 179 6.48864001549547e-25 2 2882180
SGTC_2620 irigenin 100 µM 10.2193082618092 4.13206012060415e-09 yes 180 8.12481446208894e-25 5 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_815 1582-0027 36.9 µM 10.217486446588 4.15769764320738e-09 yes 181 8.27893179700424e-25 1 3128206
SGTC_2233 sulbentine 40.3845 µM 10.2174437375577 4.15830051816173e-09 yes 182 8.2825793168677e-25 7 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_743 1275-0778 158 µM 10.1748577248037 4.80371826751206e-09 yes 183 1.28387479172365e-24 4 2849257 YMR203W TOM40
SGTC_2483 5729050 27.16 µM 10.1315486403895 5.55961749511788e-09 yes 184 2.00129641530268e-24 2 2865180
SGTC_2217 6934799 96.0675 µM 10.1001234365338 6.17922567428033e-09 yes 185 2.75863496595897e-24 1 675606
SGTC_847 0342-0274 5.54 µM 9.94325782302405 1.04219860392846e-08 yes 186 1.34927202269511e-23 1 18097
SGTC_2461 5755302 26.15 µM 9.92675356537768 1.10061915593992e-08 yes 187 1.59227569733378e-23 3 2788904
SGTC_1403 3909-7815 62.9 µM 9.82816945803772 1.52172616004188e-08 yes 188 4.25762257561956e-23 2 6615483
SGTC_2420 aureobasidin a 50 nM 9.79944049674984 1.67141792489925e-08 yes 189 5.66054906754383e-23 3 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_3025 9087895 49.47 µM 9.79602087546035 1.6901597548041e-08 yes 190 5.85541882076016e-23 4 17173641
SGTC_7 0192-1582 4.227 µM 9.74083257919059 2.02236085624095e-08 yes 191 1.00946681803986e-22 7 252616
SGTC_67 0335-0847 266 µM 9.72035976671313 2.16103015143326e-08 yes 192 1.23453781496503e-22 25 4552207 YOR254C SEC63
SGTC_843 0310-0051 143 µM 9.63051351771872 2.8865204139885e-08 yes 193 2.97158615827263e-22 1 2065037
SGTC_3210 9128157 49.47 µM 9.59953100072307 3.18761979622375e-08 yes 194 4.01545052897163e-22 2 17590849
SGTC_21 0849-0113 22.993 µM 9.47755271588911 4.69708295571593e-08 yes 195 1.30158237085564e-21 4 1560156
SGTC_3306 9127676 59.7925 µM 9.424979859983 5.54316246850775e-08 yes 196 2.15094059087474e-21 1 41905287
SGTC_1545 lovastatin 49.4 µM 9.40721674877584 5.86103649653456e-08 yes 197 2.54724035479079e-21 2 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_481 bay k-8644 50 µM 9.35755308176009 6.84621310233039e-08 yes 198 4.08023077041754e-21 2 2303 A calcium channel antagonist.
SGTC_2618 avocadyne 43.43 µM 9.35280490313051 6.94838235897479e-08 yes 199 4.26767920665939e-21 11 3015189
SGTC_1464 k208-0027 110 µM 9.33852898000477 7.26452713913412e-08 yes 200 4.88408815741458e-21 4 X1464
SGTC_1596 piperlongumine 63 µM 9.26110220897525 9.23677161686275e-08 yes 201 1.01166310358487e-20 1 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2158 5657123 3.6195 µM 9.25443606394151 9.42892987652616e-08 yes 202 1.07682124143839e-20 1 2858827
SGTC_1276 0871-0068 94.2 µM 9.22181359140753 1.04264099030328e-07 yes 203 1.46058477209174e-20 1 3414906
SGTC_1685 st024049 53.0905 µM 9.21987078740617 1.04889261762871e-07 yes 204 1.48729224715683e-20 1 1941139
SGTC_1679 SEC14.276 6.7 µM 9.17813223171918 1.19228956362147e-07 yes 205 2.19316590483077e-20 14 1005053 YMR079W SEC14
SGTC_150 3970-0969 77.2 µM 9.16659535624049 1.23515541807686e-07 yes 206 2.44097136439771e-20 4 6615640
SGTC_1616 st002734 56.1 µM 9.16261971443055 1.25026914339099e-07 yes 207 2.53262242433505e-20 2 4026101
SGTC_2086 5274770 176.623 µM 9.15557792403541 1.27747863110799e-07 yes 208 2.70338112351743e-20 1 689278
SGTC_3311 9131146 2.8755 µM 9.11988210549505 1.42444420918293e-07 yes 209 3.76030481725787e-20 22 4900406 YPR165W RHO1
SGTC_354 2783-3500 4.88 µM 9.10012707479151 1.51266370693052e-07 yes 210 4.51131001475433e-20 5 6740761
SGTC_398 bronopol 33.3 µM 9.09803385810107 1.52231465328163e-07 yes 211 4.59909123285453e-20 2 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_3064 1327-0027 10 µM 9.08497077548047 1.58389999859516e-07 yes 212 5.18632723177891e-20 3 16000455 YPR107C YTH1
SGTC_462 ag-879 158 µM 9.07751755843425 1.62010840812299e-07 yes 213 5.55396562753228e-20 2 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1928 4'-methoxychalcone 40.3 µM 9.05714546393037 1.72320197581552e-07 yes 214 6.69544800531459e-20 1 641818
SGTC_2487 5918373 44.05 µM 9.04366400556184 1.79487688629009e-07 yes 215 7.57532166117872e-20 2 2876279
SGTC_1333 1482-0047 286 µM 9.00691662925648 2.0051614109198e-07 yes 216 1.05965536890346e-19 1 3811116
SGTC_149 3970-0822 46.1 µM 8.92073115276844 2.59575885938027e-07 yes 217 2.31609917751761e-19 13 3114250 YBL034C STU1
SGTC_1029 k015-0030 64.7 µM 8.84893820522259 3.21273406170506e-07 yes 218 4.41779383905112e-19 1 2208316
SGTC_2858 9025781 8.96 µM 8.84709708036758 3.23028188471884e-07 yes 219 4.49126241415143e-19 25 4894980 YPL153C RAD53
SGTC_3063 1327-0034 4 µM 8.83509398965875 3.34696854304179e-07 yes 220 5.00070668257685e-19 12 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1696 st025591 34.7925 µM 8.83107502444783 3.38693834220447e-07 yes 221 5.18372085138117e-19 3 2787147
SGTC_1883 5-benzylidenerhodanine 20 µM 8.76961640849774 4.05855253958064e-07 yes 222 8.96379926827048e-19 12 1273210
SGTC_410 α-linolenic acid 100 µM 8.7523487329259 4.26924597843094e-07 yes 223 1.04478753599998e-18 3 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_332 4112-0506 40.9 µM 8.7226517882577 4.6564649734286e-07 yes 224 1.35880507894302e-18 2 2790355
SGTC_710 3448-4187 58 µM 8.69968149895398 4.97894819559928e-07 yes 225 1.66408475781763e-18 7 3946412
SGTC_670 4204-0025 119 µM 8.69670845303316 5.02222641150701e-07 yes 226 1.70824874583774e-18 4 719039
SGTC_3022 9087993 49.47 µM 8.62148426319218 6.24588179378677e-07 yes 227 3.30458847957017e-18 1 17173644
SGTC_2479 5617353 43.85 µM 8.56505211822248 7.34722380174466e-07 yes 228 5.40134855892432e-18 1 2731746
SGTC_2580 diallyl disulphide 81.36 µM 8.56250730661206 7.40105238573434e-07 yes 229 5.52195199827413e-18 2 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 8.48814062259521 9.15256360664186e-07 yes 230 1.04984703100759e-17 10 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_304 1310-0298 97 µM 8.44022065743644 1.04853505458127e-06 yes 231 1.58369574859794e-17 4 1550234
SGTC_214 4373-3496 70 µM 8.41849859799743 1.11491521296925e-06 yes 232 1.90669866877037e-17 2 3779166
SGTC_3118 9124250 49.47 µM 8.38754065823423 1.21653223832971e-06 yes 233 2.48208759617683e-17 1 1504786
SGTC_1195 1502-0147 41.1 µM 8.22792181607044 1.89824750936815e-06 yes 234 9.52446715396632e-17 2 817940
SGTC_586 0957-0265 8.15 µM 8.22045402289966 1.93779333734869e-06 yes 235 1.01367099610776e-16 6 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2456 5770359 74.46 µM 8.11419517589175 2.59354298712199e-06 yes 236 2.4450744971805e-16 1 3118787
SGTC_36 0335-0881 14.2 µM 8.00784979191588 3.45965448005972e-06 yes 237 5.83656774808469e-16 36 23828853
SGTC_628 1636-0253 16 µM 8.00215919787211 3.5130579635944e-06 yes 238 6.11280890153583e-16 5 4456143
SGTC_2529 gangaleoidin 93.61 µM 7.91651403748517 4.41848287648987e-06 yes 239 1.22131086188753e-15 2 4565183
SGTC_804 1595-0054 20.9 µM 7.87408092325481 4.94586503519614e-06 yes 240 1.71628363291664e-15 5 761523 Stimulates phospholipase C.
SGTC_1179 1021-1431 9.29 µM 7.75460629892379 6.77324084776329e-06 yes 241 4.43089841542766e-15 6 2840958
SGTC_1859 st055998 20 µM 7.71150491723011 7.57845242464508e-06 yes 242 6.21713333017499e-15 2 676301
SGTC_1923 st058458 19.1 µM 7.70158720901762 7.77624429082194e-06 yes 243 6.71932050711898e-15 3 3534982
SGTC_585 0kpi-0023 191 µM 7.61703951912694 9.67415278978538e-06 yes 244 1.29779943584871e-14 5 64601
SGTC_2833 9001315 45.46 µM 7.61140671976349 9.81515058590717e-06 yes 245 1.35564274429214e-14 6 2989378
SGTC_213 1246-0773 967 nM 7.58049336183178 1.06244684982272e-05 yes 246 1.72121689901071e-14 1 6251622
SGTC_352 k048-0007 5.11 µM 7.49653372840681 1.31554684557644e-05 yes 247 3.2763780455778e-14 19 6811911
SGTC_1273 0849-0096 14.1 µM 7.44605028803455 1.49431446271738e-05 yes 248 4.8088078942398e-14 1 5286025
SGTC_1117 retinoic acid 1.10837 µM 7.43728169283757 1.52762931481124e-05 yes 249 5.13891171949589e-14 2 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2751 anetholtrithion 17.25 µM 7.43097535880294 1.55202427762315e-05 yes 250 5.38998974558439e-14 3 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_137 0438-0332 85.389 µM 7.39287270107311 1.70747810735267e-05 yes 251 7.1845015188761e-14 44 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_3038 9091290 49.47 µM 7.3902942855847 1.71851520477279e-05 yes 252 7.32520988390069e-14 1 25236843
SGTC_2332 7982454 138.89 µM 7.36669760136418 1.82271893491429e-05 yes 253 8.74533080487614e-14 7 2981748
SGTC_764 1951-2361 146 µM 7.32742169003624 2.00958273019651e-05 yes 254 1.17311340823554e-13 2 5438930
SGTC_820 1582-0060 59.9 µM 7.32228757899271 2.03531227749936e-05 yes 255 1.21889511093674e-13 2 3848840
SGTC_836 0330-0104 1.35 µM 7.309722561056 2.09960683855122e-05 yes 256 1.33847260827877e-13 1 46494820
SGTC_2551 apiole 73.87 µM 7.23433015209332 2.52773090623265e-05 yes 257 2.33916212096795e-13 1 10659 A possible DNA adduct former.
SGTC_2458 5808907 16.39 µM 7.20278527563047 2.73037448511756e-05 yes 258 2.94974199764366e-13 1 2731747
SGTC_1346 1488-2224 62.4 µM 7.20117610582157 2.74111372940112e-05 yes 259 2.98476932815844e-13 5 3722427
SGTC_483 fpl-64176 144 µM 7.14675729844331 3.12877223673965e-05 yes 260 4.4425883543205e-13 2 3423
SGTC_2246 7293507 91.5585 µM 7.12396341218675 3.30610470278583e-05 yes 261 5.24334461825359e-13 8 887656
SGTC_776 4476-4378 112 µM 7.05114733883364 3.93848962858856e-05 yes 262 8.87242368348023e-13 3 2892008
SGTC_274 sirtinol 40.1 µM 7.03976209020183 4.04715424976517e-05 yes 263 9.6284172201768e-13 3 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_487 nimodipine 119 µM 7.03448175252781 4.09850792461985e-05 yes 264 1.00001486480012e-12 1 4497 L-type voltage-gated calcium channels inhibitor
SGTC_611 3453-1652 23.7 µM 7.00674679254451 4.3785110047974e-05 yes 265 1.21961560762025e-12 2 1560575
SGTC_225 nsc-122657 1.016 µM 6.99277862927724 4.52628038230597e-05 yes 266 1.3474728597368e-12 2 275685
SGTC_309 k408-0051 1.48 µM 6.99028841808525 4.55311423647216e-05 yes 267 1.37160855729262e-12 8 3640463
SGTC_459 nigericin 15.3 µM 6.94815520388446 5.03054559729761e-05 yes 268 1.85046863850321e-12 21 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_86 0417-1630 471.922 µM 6.88372131243936 5.85299191575728e-05 yes 269 2.91544476453085e-12 74 3634867
SGTC_457 grayanotoxin iii 135 µM 6.73366353658155 8.28611975421982e-05 yes 270 8.2721757326656e-12 17 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2484 5809818 12.04 µM 6.71777883334582 8.59319162703906e-05 yes 271 9.22577302589414e-12 2 2870548
SGTC_1433 4060-0023 7.6 µM 6.71406794701957 8.66645423321381e-05 yes 272 9.46360516974716e-12 5 3840627
SGTC_2132 5317594 122.667 µM 6.63931229234477 0.000102735024331543 yes 273 1.57575026833443e-11 10 794577
SGTC_2907 7721985 69.9 µM 6.61870579352797 0.000107634154586611 yes 274 1.8117860029318e-11 2 3267881
SGTC_1777 st045864 34.765 µM 6.6172265097441 0.000107994159067438 yes 275 1.83000238751018e-11 1 4691462
SGTC_1471 k673-0312 37 µM 6.56946688848203 0.000120243321221301 yes 276 2.52478607817767e-11 2 24099884
SGTC_2498 4'-Methoxychalcone 54.63 µM 6.56693705812424 0.00012092720007498 yes 277 2.56803716641551e-11 3 641818 YHR062C RPP1
SGTC_1082 camptothecin 424.86 nM 6.56065258274952 0.000122641881173903 yes 278 2.67864024069116e-11 17 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_337 1315-0038 354 µM 6.52972984269115 0.000131416249729159 yes 279 3.29442141864813e-11 8 1626437
SGTC_1232 0279-0259 161 µM 6.50253767178964 0.000139615061718747 yes 280 3.94881173013056e-11 2 1560000
SGTC_1320 1313-0481 95.3 µM 6.45251092581547 0.000155964710351578 yes 281 5.50059745325659e-11 3 6813365 YLR208W SEC13
SGTC_572 0960-0087 17.7 µM 6.44019752642033 0.000160255268580549 yes 282 5.96590581550597e-11 3 6796365
SGTC_490 phenamil 164 µM 6.42619313375001 0.000165269238246409 yes 283 6.54195753977713e-11 1 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2084 5306078 60.6385 µM 6.35177270324827 0.000194468726893816 yes 284 1.06423835916113e-10 2 679340
SGTC_2457 5731572 11.68 µM 6.34638362410595 0.000196760280669506 yes 285 1.10217577029332e-10 3 2865357
SGTC_2073 5212005 126 µM 6.3459700103294 0.000196937196782175 yes 286 1.10514146091947e-10 1 691789
SGTC_1873 rapamycin 2 nM 6.31783610290258 0.000209325960950978 yes 287 1.32625551589042e-10 31 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2031 5180455 200 µM 6.29496816608683 0.000219928104393964 yes 288 1.53731475889841e-10 4 29949
SGTC_2480 5767542 37.17 µM 6.26138767796926 0.000236408363704334 yes 289 1.9078330408861e-10 2 2867358
SGTC_1762 st045503 25.4615 µM 6.25422196283707 0.000240071065398281 yes 290 1.99751246150455e-10 3 4645554
SGTC_984 1492-0255 2.91 µM 6.1803798791196 0.000281024246709916 yes 291 3.19737687547475e-10 9 1585198
SGTC_2759 disulfiram 3.38 µM 6.17939075471543 0.000281614558873314 yes 292 3.21747220608791e-10 5 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3297 9117502 71.43 µM 6.1512904632432 0.000298875224337507 yes 293 3.84275080256055e-10 2 7453720
SGTC_2636 apigenin dimethyl ether 100 µM 6.12025165309099 0.000319082655687193 yes 294 4.67138444149888e-10 10 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_903 1134-0042 114 µM 6.10864432667568 0.000326960645462581 yes 295 5.02404853499003e-10 4 701009
SGTC_687 k029-0044 34.9 µM 6.09761682591435 0.000334612307632581 yes 296 5.38307168155479e-10 3 5829338
SGTC_2183 6420625 130.508 µM 6.05858056651898 0.000363056563301485 yes 297 6.86639804102368e-10 12 2897619
SGTC_1872 amphotericin b 148 nM 6.05099838635249 0.000368835565984435 yes 298 7.19754451370426e-10 10 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2394 5221648 200 µM 5.99840214364852 0.000411336292499187 yes 299 9.96342715786102e-10 4 788586
SGTC_2173 5763948 167 µM 5.9646118866758 0.000440991904558878 yes 300 1.22608097031518e-09 3 2867177
SGTC_1820 st053765 18.6 µM 5.95580057738491 0.000449044476502786 yes 301 1.29400880342728e-09 1 3690829
SGTC_2328 6201408 200 µM 5.94930764348019 0.000455065291125375 yes 302 1.34639546781959e-09 2 2890418
SGTC_767 0929-0023 86 µM 5.94522016269061 0.000458893841850979 yes 303 1.38042763258893e-09 23 1204563
SGTC_896 0964-0007 44.5 µM 5.93716735520718 0.000466523999722488 yes 304 1.44994308881318e-09 3 6756758
SGTC_2534 helenine 20.12 µM 5.9300943754086 0.000473322542014224 yes 305 1.51380306706683e-09 5 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2067 5224629 34.075 µM 5.89626762942882 0.000507124151681318 yes 306 1.85907871478775e-09 4 2835000
SGTC_1055 3448-0672 86 µM 5.84761030095282 0.000559676750938001 yes 307 2.49342578677957e-09 10 748378
SGTC_2189 6047310 154.431 µM 5.84256164973759 0.000565408640806744 yes 308 2.57020766240616e-09 4 711535
SGTC_1277 0873-0036 22 µM 5.82448880515048 0.000586375083595456 yes 309 2.86438388975871e-09 7 5965735
SGTC_2750 bromebric acid 70.15 µM 5.82007167627768 0.000591607540261207 yes 310 2.94111984354114e-09 5 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1954 st077032 68.9 µM 5.80955985752459 0.000604233637508856 yes 311 3.1318648300047e-09 2 698907
SGTC_1800 st050079 29.0735 µM 5.80534196615491 0.000609369505616114 yes 312 3.2117383069039e-09 43 3645560
SGTC_1833 st055984 71 µM 5.72459588707622 0.000715800464192674 yes 313 5.18401181161395e-09 4 676288
SGTC_2788 5282734 71.43 µM 5.71027650898739 0.000736375261053661 yes 314 5.63963832049216e-09 14 743706
SGTC_1237 0330-0133 46.1 µM 5.66144788026172 0.000810701635378097 yes 315 7.50505487921085e-09 7 X1237 YHR072W ERG7
SGTC_3318 9139014 38.6185 µM 5.65498392220058 0.000821042638073074 yes 316 7.79304308866916e-09 6 16643984
SGTC_129 0088-0017 176.636 µM 5.65485015226511 0.00082125791873184 yes 317 7.79911485844543e-09 33 182446
SGTC_2508 celastrol 40.54 µM 5.64859335375193 0.00083138542896537 yes 318 8.08829997419252e-09 7 122724 Celastrol is a natural product and antioxidant.
SGTC_2065 5221596 34.26 µM 5.6412914339255 0.000843349854379211 yes 319 8.438970062209e-09 2 788581
SGTC_799 1310-0557 151 µM 5.56803562716236 0.000972456168429573 yes 320 1.28813578515201e-08 8 5354492
SGTC_182 3448-4371 550.524 µM 5.55830884249043 0.000990901196593069 yes 321 1.36200535719452e-08 11 3491403
SGTC_1934 st074720 32.6 µM 5.55381419180217 0.000999532472822462 yes 322 1.39751291308945e-08 17 17250992
SGTC_2469 5655019 90.81 µM 5.54884819934618 0.00100914908506409 no 323 1.43778856017413e-08 4 2788239
SGTC_284 0988-0104 32.6 µM 5.50598123801271 0.00109575914967346 no 324 1.83558814812446e-08 2 4666532
SGTC_841 0251-0215 91.2 µM 5.50360496165181 0.00110075398669296 no 325 1.86051411925804e-08 44 3888614
SGTC_148 3253-0744 288.01 µM 5.50148107037573 0.00110523597232629 no 326 1.88307027038314e-08 5 6893655
SGTC_3197 9113331 49.47 µM 5.47554168937181 0.00116134106121633 no 327 2.18087627416378e-08 9 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_159 3970-0959 50 µM 5.45885761757463 0.0011987934538966 no 328 2.3960392384994e-08 32 6615653
SGTC_592 k241-0073 46.5 µM 5.4452513176629 0.00123015184560779 no 329 2.58661460338781e-08 8 4230158
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 5.44121165280667 0.00123960552290862 no 330 2.64596975442391e-08 5 5355888
SGTC_502 l-744,832 89.3 µM 5.37220247288293 0.00141171282613419 no 331 3.88903503613266e-08 15 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2739 tacrine 100.86 µM 5.36789847157455 0.00142313784880927 no 332 3.98296860203657e-08 3 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_305 1682-2595 20.8 µM 5.3314168693098 0.00152342254512053 no 333 4.87247145699066e-08 7 226033
SGTC_1506 4226-2149 212 µM 5.30657717619414 0.00159534876880349 no 334 5.58514394085056e-08 9 991114
SGTC_3074 9116018 49.47 µM 5.30537008384041 0.00159892164668003 no 335 5.62223145000061e-08 6 17027303
SGTC_2098 5376439 882.5 nM 5.26455727079186 0.00172409997653493 no 336 7.0263794510022e-08 2 2844116
SGTC_3121 9125696 49.47 µM 5.2550877656934 0.00175439069630267 no 337 7.39769492074464e-08 2 1235365
SGTC_994 3910-0338 138 µM 5.24726576398728 0.001779775775174 no 338 7.71865660237003e-08 20 3479481
SGTC_668 1682-0499 62.6 µM 5.22855876756106 0.00184184710101485 no 339 8.54182663827121e-08 8 682214
SGTC_2651 TUB2.036 5 µM 5.22724844542428 0.00184626775851133 no 340 8.60256217941191e-08 101 15992207 YFL037W TUB2
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 5.21593508892536 0.00188483890720183 no 341 9.14461096329964e-08 2 688798
SGTC_598 3937-0236 20.2 µM 5.21560527623105 0.00188597425945941 no 342 9.16089821425997e-08 12 1379313
SGTC_1063 disulfiram 1.84 µM 5.19690445220164 0.0019513761229193 no 343 1.01317223193136e-07 7 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2284 7945075 39.21 µM 5.19280512442162 0.00196598504961827 no 344 1.03574490868029e-07 11 1245402
SGTC_1737 st035557 69.7 µM 5.16353104315906 0.0020732310278612 no 345 1.21167185053051e-07 6 5716916
SGTC_1952 st077036 64.1 µM 5.13104155140912 0.00219845006365335 no 346 1.44071644032606e-07 10 2937007
SGTC_2520 obtusaquinone 4.71 µM 5.02474238976229 0.00265750743722747 no 347 2.52054372536341e-07 3 5967872
SGTC_1974 st069448 26.9 µM 5.02191444673815 0.00267082362858166 no 348 2.55794858358277e-07 8 6323587 YNR016C ACC1
SGTC_1410 3909-8106 77.9 µM 5.00687165600781 0.00274267500830626 no 349 2.76608938231633e-07 4 1039210
SGTC_98 0074-0023 107.663 µM 4.99656366626022 0.00279291334482732 no 350 2.9180456798014e-07 20 3563821
SGTC_1451 4152-0210 104 µM 4.95771055514277 0.00298982138105792 no 351 3.56643610111126e-07 8 659563
SGTC_1549 4'-methoxyflavonol 74.6 µM 4.94197120527987 0.00307308678022334 no 352 3.86683199358526e-07 2 97141
SGTC_1742 st038235 28.8875 µM 4.91860398970495 0.00320056002965998 no 353 4.35818038102609e-07 79 564103 YBR002C RER2
SGTC_2027 5150920 200 µM 4.91166941824324 0.00323929457040859 no 354 4.51521061634568e-07 2 786715
SGTC_2035 5154463 94.595 µM 4.89189652432321 0.0033520664017073 no 355 4.99344744336151e-07 4 2769623
SGTC_3338 9144300 39.5675 µM 4.88983177129602 0.003364043607298 no 356 5.04610952867627e-07 9 4901274
SGTC_420 mitomycin C 81.9 mM 4.88494996221658 0.00339251510294649 no 357 5.17275618383776e-07 6 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_621 3584-0052 32.1 µM 4.88221809692239 0.00340854210879061 no 358 5.24495707363817e-07 15 2273927
SGTC_1831 st055328 12 µM 4.86030250397621 0.00353959630754024 no 359 5.86032593292947e-07 12 1103068
SGTC_2435 5706476 10.6 µM 4.8516894881631 0.00359232804455133 no 360 6.12070873980477e-07 10 5725375
SGTC_3286 9117135 37.221 µM 4.8067565281655 0.00387902513541094 no 361 7.6699307416014e-07 3 3438150
SGTC_642 0335-0876 158 µM 4.79950554122646 0.00392716456878717 no 362 7.95289177216098e-07 22 6812350
SGTC_2716 st080858 38.6235 µM 4.79419756795685 0.00396274285010571 no 363 8.16636269230167e-07 9 5296050
SGTC_1801 st050089 28.441 µM 4.77659799043332 0.00408278385979415 no 364 8.91428468521892e-07 83 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_695 3505-6186 243 µM 4.77459535372148 0.0040966473918641 no 365 9.00344746119114e-07 14 1819379
SGTC_3160 9100216 49.47 µM 4.77390063666008 0.00410146650096485 no 366 9.03457786555846e-07 1 17191039
SGTC_444 curcumin 90.4 µM 4.75714494817086 0.00421924457269332 no 367 9.81750931034387e-07 12 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1240 0356-0016 42.1 µM 4.71736053530648 0.004511096462523 no 368 1.19462036906213e-06 21 4305613
SGTC_429 1112-0049 25.5 µM 4.70106202885748 0.00463577486407409 no 369 1.2940593726852e-06 23 2836170
SGTC_2801 7907800 81.82 µM 4.6978494539805 0.00466070974189655 no 370 1.31457550906482e-06 16 6620925
SGTC_704 1310-0270 142 µM 4.68020547510352 0.00479980133991253 no 371 1.43293772346574e-06 22 5718033
SGTC_2473 5854593 8.94 µM 4.67392784883505 0.00485017484059741 no 372 1.47746589013012e-06 4 2872951
SGTC_543 3844-1095 191 µM 4.65651188584517 0.00499240149944206 no 373 1.60805860361193e-06 35 4230703
SGTC_1917 st066507 28.5 µM 4.64257730181776 0.00510886045687516 no 374 1.72044918907263e-06 26 3156428
SGTC_2744 captopril 92.04 µM 4.64022317841893 0.00512877219519427 no 375 1.74016551662397e-06 5 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_735 3076-0345 636 µM 4.6041592241972 0.00544256309761929 no 376 2.07067766871788e-06 17 2888990
SGTC_748 act1.228 77.9 µM 4.60014353151827 0.00547853829956216 no 377 2.11099965101247e-06 58 4421505 YNR035C ARC35
SGTC_2358 9037157 4 µM 4.55541982022604 0.00589371510598171 no 378 2.61405276679981e-06 16 2388925
SGTC_1369 1866-0067 208 µM 4.55257404926302 0.0059210532489024 no 379 2.64967495344517e-06 25 3531355
SGTC_335 4077-0256 27.6 µM 4.53844112887195 0.00605849515010609 no 380 2.83358060920122e-06 11 3121989
SGTC_2541 muurolladie-3-one 83.07 µM 4.52203286496805 0.00622160552047285 no 381 3.06242734450563e-06 15 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1039 k821-0043 94 µM 4.51637689075643 0.0062787248134142 no 382 3.14533305295282e-06 15 15992768
SGTC_293 4049-0273 38.5 µM 4.49809182646684 0.00646657401295831 no 383 3.42830418079677e-06 10 1380311
SGTC_142 0335-0849 62.6745 µM 4.48894557550315 0.006562389152442 no 384 3.5788289762316e-06 104 3889043 YPR107C YTH1
SGTC_2417 cerulenin 830 nM 4.48060888889828 0.00665081484025957 no 385 3.7215197417104e-06 21 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_165 k038-0023 64.381 µM 4.47763466491707 0.00668261585589949 no 386 3.77373090159958e-06 60 46368543
SGTC_3235 9132602 49.47 µM 4.47393987306381 0.00672230846275039 no 387 3.83956719336845e-06 12 4912240
SGTC_200 k038-0079 37.545 µM 4.46814104127179 0.00678502461298048 no 388 3.94511391659551e-06 46 3436683
SGTC_2109 5483026 200 µM 4.45577981665528 0.00692044310641777 no 389 4.17943949288875e-06 16 759335
SGTC_1550 gossypolone 36.6 µM 4.42223239214621 0.00730005801541214 no 390 4.88431516721272e-06 7 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_683 panaxydol 45 µM 4.40419394922475 0.00751167200360386 no 391 5.3088960227721e-06 23 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_371 0195-0006 7.36 µM 4.38835858254287 0.00770187584729023 no 392 5.71046801938305e-06 13 3928593
SGTC_2800 7887935 81.82 µM 4.36012962130314 0.00805147596315528 no 393 6.4992711298506e-06 17 2961002
SGTC_1361 1608-0041 5.61 µM 4.35993997690887 0.0080538710174659 no 394 6.50490623471881e-06 12 X1361
SGTC_2691 st077356 60.2 µM 4.34156776792975 0.0082888866042157 no 395 7.07348148772015e-06 18 2839272
SGTC_773 4358-1457 44.6 µM 4.31611431356366 0.00862442842261105 no 396 7.93998824685301e-06 34 1186886
SGTC_216 k038-0035 28.382 µM 4.25421274079962 0.00949060734736825 no 397 1.04892890242223e-05 39 4444231 YPR107C YTH1
SGTC_389 tpck 16.7 µM 4.23803471947935 0.00972915877846983 no 398 1.1274245267634e-05 24 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_537 1334-0398 209 µM 4.21782506660275 0.0100345053335331 no 399 1.23335032776923e-05 18 5846986
SGTC_2452 5863136 48.41 µM 4.21272432426677 0.0101128815910063 no 400 1.26154465557572e-05 18 2184096
SGTC_964 1287-0107 19.4 µM 4.18546447305599 0.0105408659440916 no 401 1.42291789234878e-05 32 51516812 YPR165W RHO1
SGTC_265 mycophenolic acid 32.932 µM 4.16284342987948 0.0109079169437422 no 402 1.57154448215995e-05 12 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1262 0737-0114 49.6 µM 4.12164203955572 0.0116050929763017 no 403 1.88090707436988e-05 17 765919
SGTC_2371 9071574 200 µM 4.10555162263987 0.011887688070821 no 404 2.01675595654172e-05 11 45596039
SGTC_996 3970-0799 1.8 µM 4.07881377183003 0.0123704919121178 no 405 2.26330390524091e-05 79 6615648 YGL040C HEM2
SGTC_1902 st060212 70.5 µM 4.06310867280336 0.012661923534726 no 406 2.42117356723153e-05 10 688944
SGTC_2470 5664817 21.68 µM 4.06211175118401 0.0126806218255755 no 407 2.43153928070011e-05 7 2859561
SGTC_2465 5809242 33.21 µM 4.05698797381911 0.0127771010046631 no 408 2.48548202835013e-05 2 2731748
SGTC_184 1494-0393 24.714 µM 4.05089818550102 0.0128925952260659 no 409 2.55107029756464e-05 56 3090647
SGTC_2785 7756463 72.73 µM 4.01672377607129 0.013557610299015 no 410 2.95064131429162e-05 27 2201551
SGTC_852 0418-0143 439 µM 4.01179127541535 0.0136559981213264 no 411 3.01298837965762e-05 66 5369229
SGTC_1887 st057648 70.8 µM 3.9827848427244 0.0142471377036083 no 412 3.40562072281997e-05 14 688672
SGTC_1452 4194-0072 190 µM 3.96403365150941 0.0146409003702934 no 413 3.68469286600257e-05 13 1343545
SGTC_2446 5162541 200 µM 3.94691943782688 0.0150084251218532 no 414 3.95815895911375e-05 11 1549321
SGTC_3337 9144342 33.5465 µM 3.94183737665155 0.0151190771698519 no 415 4.04298978681861e-05 26 17682949
SGTC_666 0272-0154 136 µM 3.93696950881546 0.0152257221354036 no 416 4.12585435361188e-05 54 6870312
SGTC_378 3970-0959 8.33 µM 3.92730669401753 0.0154393300027368 no 417 4.29512064463432e-05 17 6615653
SGTC_796 1234-0020 70.7 µM 3.924947711055 0.0154918671023195 no 418 4.33742895151045e-05 28 46495034
SGTC_881 0833-0569 170 µM 3.91474670247212 0.0157208247898264 no 419 4.52495818590212e-05 29 5418700
SGTC_1424 4048-1941 275 µM 3.89290797739349 0.0162207617303882 no 420 4.95248658132264e-05 26 X1424
SGTC_379 3970-0972 5.9 µM 3.87971125855186 0.0165294175729399 no 421 5.22902680125726e-05 40 2898042 YBL034C STU1
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 3.87970254131658 0.0165296231089015 no 422 5.22921419767428e-05 22 5024745
SGTC_1736 st036774 51 µM 3.87566229115289 0.0166251203532042 no 423 5.31675391737466e-05 36 1272247
SGTC_2507 purpurin 79.67 µM 3.86209739688254 0.0169492076379776 no 424 5.62088644422085e-05 41 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2862 9027634 71.43 µM 3.85994786342316 0.0170010560908983 no 425 5.67056098564728e-05 32 5012562
SGTC_291 SEC14.278 35.5 µM 3.84704577353282 0.0173151224934333 no 426 5.97753203120248e-05 18 1068044
SGTC_376 3970-0862 59.1 µM 3.84172344912131 0.0174461165796889 no 427 6.10867220797946e-05 22 3135186
SGTC_1342 1486-1464 234 µM 3.83946718912208 0.0175019029602739 no 428 6.16508027725921e-05 18 3253938
SGTC_1265 0819-1001 68.8 µM 3.8363126409894 0.0175801549224142 no 429 6.2447698214403e-05 28 3106768
SGTC_2004 4023728 41.89 µM 3.83488466943825 0.0176156753660566 no 430 6.28116129543803e-05 30 360084 YDR527W RBA50
SGTC_2186 6124449 200 µM 3.79908876048814 0.0185263123145416 no 431 7.26145385930333e-05 22 3834182 YLR033W RSC58
SGTC_3108 9121785 49.47 µM 3.79357202621606 0.0186701612663081 no 432 7.42477652359919e-05 16 17140271
SGTC_2386 9075165 157.42 µM 3.78423521128724 0.0189157850217742 no 433 7.70909792909823e-05 12 16452277
SGTC_2007 4011539 71.82 µM 3.76652701644396 0.0193891897531662 no 434 8.27670893285512e-05 71 45595301
SGTC_3165 9101544 49.47 µM 3.76569557453947 0.0194116624640324 no 435 8.30430287649709e-05 13 5002184
SGTC_1418 3966-3099 2.4 µM 3.74919393961691 0.0198622773568581 no 436 8.87019285635864e-05 27 740335
SGTC_1092 toremifene 6.32 µM 3.74770693930092 0.0199033158271228 no 437 8.92292940119425e-05 24 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2905 7799065 20.05 µM 3.72546679919558 0.0205257388941805 no 438 9.7477056234116e-05 15 1296806
SGTC_2897 9048598 12.99 µM 3.72442172804657 0.0205553879586733 no 439 9.7881718454518e-05 20 6467404
SGTC_2753 fluvastatin 17.09 µM 3.70107926818613 0.0212271386233346 no 440 0.00010734219588288 47 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_725 1497-0963 19 µM 3.66986645920996 0.0221543182446392 no 441 0.000121338606073137 24 3549977
SGTC_3131 9127911 49.47 µM 3.66769463945529 0.0222200849725696 no 442 0.000122373614167928 39 45595681
SGTC_190 3970-0790 3.722 µM 3.65006736132401 0.0227599906112532 no 443 0.000131085773050807 12 2832352
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 3.64925220701543 0.0227852231041253 no 444 0.000131502397930465 36 115019
SGTC_107 0358-0022 2.6945 µM 3.64437514494666 0.0229366818247755 no 445 0.00013402110813021 33 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_445 e6 berbamine 66 µM 3.64299259464809 0.0229797713344341 no 446 0.000134743297050467 132 6610268 A calcium/calmodulin antagonist.
SGTC_1882 5615643 20 µM 3.63941953273514 0.0230914477374609 no 447 0.000136626653205918 37 2253075
SGTC_761 k216-0224 480 µM 3.63582509867364 0.0232042528939788 no 448 0.000138546147628777 29 1340404
SGTC_377 3970-0964 33.1 µM 3.63546511188307 0.0232155759770012 no 449 0.000138739773245507 52 16481235
SGTC_1193 1488-0126 41.5 µM 3.62983310711197 0.023393332469846 no 450 0.000141802263991945 33 1384710
SGTC_2026 5148700 152 µM 3.61517166168751 0.0238614534820896 no 451 0.000150074334522736 26 79838
SGTC_1546 5-methoxyflavanone 78.7 µM 3.60992064581506 0.0240310155398279 no 452 0.000153145346959571 16 147795
SGTC_158 k038-0087 26.446 µM 3.60682430869448 0.0241314739296185 no 453 0.0001549836914242 162 X158
SGTC_2923 7992654 58.14 µM 3.58799093916225 0.0247501359248691 no 454 0.000166617933844275 42 2985126
SGTC_2085 5307070 144.047 µM 3.58765873939873 0.0247611667463106 no 455 0.000166830299535451 41 2840351
SGTC_1803 st050068 52.4 µM 3.5683555059538 0.0254092569367718 no 456 0.000179614436514682 210 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_567 1080-0542 68.4 µM 3.55406887786826 0.0258980167789958 no 457 0.000189659928318522 21 5950415
SGTC_2449 5812982 45.77 µM 3.50178085057535 0.0277544083003594 no 458 0.000231079795715596 16 776185
SGTC_1268 0828-0275 2.46 µM 3.48793734580031 0.0282640554883213 no 459 0.00024338106417501 38 745337
SGTC_2793 7325131 81.82 µM 3.48461091808844 0.0283876715457747 no 460 0.000246426570584228 28 4176441
SGTC_348 k064-0012 10.7 µM 3.48436370455528 0.0283968763787752 no 461 0.000246654319399127 24 5066323
SGTC_397 arbidol 50 µM 3.48329555295531 0.0284366768528873 no 462 0.000247640626523357 35 131410 A RNA synthesis inhibitor.
SGTC_2104 5389443 200 µM 3.48145372043052 0.0285054145206311 no 463 0.000249349975831922 31 2244536
SGTC_771 0250-0039 27.3 µM 3.47295159014059 0.0288245103630474 no 464 0.000257384098078614 25 3005115
SGTC_1139 k015-0024 46.9 µM 3.47049796113536 0.0289171484408744 no 465 0.000259747143487624 19 2766652
SGTC_1490 4089-0339 670 nM 3.465057773802 0.0291234284320116 no 466 0.000265058791617202 18 742542
SGTC_671 0560-0003 407 µM 3.4128286513121 0.0311667374327195 no 467 0.000321461762862486 23 3238678
SGTC_747 3448-8087 38.7 µM 3.40722359476746 0.031392898601589 no 468 0.000328136706251745 46 5168703
SGTC_350 k064-0020 19.8 µM 3.39947167121407 0.0317079192277001 no 469 0.000337580867570713 41 2790705
SGTC_2134 5324836 1.464 µM 3.39490265944222 0.0318948138775278 no 470 0.000343265022889104 28 699272
SGTC_1953 st076800 12.1 µM 3.36858487059156 0.03298913168301 no 471 0.000377775658174519 72 297591
SGTC_1996 st072960 66.8 µM 3.36481353598856 0.0331484526746631 no 472 0.000382977017772318 37 1719405
SGTC_3302 9125395 16.351 µM 3.36365224335063 0.0331976392333766 no 473 0.00038459199294781 31 17599668
SGTC_1776 st049249 45.9 µM 3.35269388345989 0.033664747355488 no 474 0.000400145834163872 33 1822314
SGTC_2770 toltrazuril 17.5 µM 3.30437113181088 0.0357894829009426 no 475 0.000475948636107909 49 68591 Kills coccidiodes.
SGTC_427 1354-0053 47.3 µM 3.29994302603307 0.0359895629622416 no 476 0.000483522293196071 44 6813657
SGTC_1721 st082152 9.2685 µM 3.29867583353398 0.0360469882495598 no 477 0.000485710100635776 43 5296051
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 3.27277730797364 0.0372371611073866 no 478 0.00053248173810647 26 6708784 An antioxidant flavonoid
SGTC_935 2996-0153 430 µM 3.26464751947466 0.0376173217561912 no 479 0.000548001868278551 44 23738523
SGTC_1956 st077085 54 µM 3.25862367315971 0.0379010444652831 no 480 0.000559770338200876 45 24208685
SGTC_603 3794-0023 45.9 µM 3.25374443561524 0.0381321340534764 no 481 0.000569473462632444 24 3802260
SGTC_2135 5326629 150.42 µM 3.23708990760374 0.0389295924897496 no 482 0.000603776803020836 58 5020077
SGTC_1086 cerivastatin 2.18 µM 3.23313755687198 0.0391208208665968 no 483 0.000612192957410095 28 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2305 7443522 69.23 µM 3.22358878467828 0.0395859798692541 no 484 0.000632975238248667 34 5415886
SGTC_45 0kpi-0036 14.9 µM 3.20529739264439 0.0404895851963531 no 485 0.000674614987687277 50 2795021
SGTC_3144 9087057 49.47 µM 3.20188219236637 0.0406601391543603 no 486 0.000682664114426696 38 17249618
SGTC_3227 9130768 49.47 µM 3.1829158121068 0.0416179525980124 no 487 0.000729000001597498 17 17720899
SGTC_2531 methyl deoxycholate 70.07 µM 3.17479772674769 0.0420334686093649 no 488 0.000749704912232527 55 16667744 Haematoxylin.
SGTC_2852 9023854 51.95 µM 3.16929857205735 0.042316840370641 no 489 0.000764036668894909 55 19798528
SGTC_1236 0330-0013 258 µM 3.1647466879105 0.0425525665762166 no 490 0.000776090103123956 35 4617066
SGTC_1184 1269-1718 139 µM 3.15867986378881 0.0428683957673701 no 491 0.000792427395696734 57 5403821
SGTC_1146 3579-1023 7 µM 3.15424736533888 0.0431003400919163 no 492 0.000804563152681931 44 X1146
SGTC_2438 5259590 200 µM 3.13348014696943 0.0442005846679194 no 493 0.000863733020589772 43 1201127
SGTC_2845 9003024 42.97 µM 3.13126350331706 0.0443193476115652 no 494 0.000870279556937316 80 2990173
SGTC_864 0469-0573 172 µM 3.12153138006532 0.0448438201329742 no 495 0.000899565363483907 54 689425
SGTC_3123 9126162 49.47 µM 3.12031806857641 0.0449095554307128 no 496 0.000903279273014545 42 25239884
SGTC_1716 st033144 30.6155 µM 3.11336838794052 0.0452875741896325 no 497 0.000924824927224116 45 674617
SGTC_2117 5521686 200 µM 3.10803624512408 0.0455793410390068 no 498 0.000941674844714413 47 803312
SGTC_1771 st048882 4.1505 µM 3.10472574165459 0.0457612459738833 no 499 0.000952277659810015 58 4580403
SGTC_2830 7992007 71.43 µM 3.09692220151563 0.0461923425883247 no 500 0.000977705927288303 50 1952075
SGTC_2925 9010536 32.5 µM 3.09352010178603 0.0463813053261992 no 501 0.000988985763249181 89 2994177
SGTC_1304 1165-0502 251 µM 3.08006524528275 0.0471347161367573 no 502 0.00103477626517695 105 767425
SGTC_942 3253-1115 227 µM 3.07906856337262 0.0471909138478129 no 503 0.00103824443605627 75 46497897
SGTC_2971 9092186 9.93 µM 3.06998673328904 0.0477054689705139 no 504 0.00107034139817849 64 25236400
SGTC_1884 5633444 25 µM 3.06856630676755 0.0477863517984217 no 505 0.00107544295355603 102 5724239
SGTC_2829 7992743 58.44 µM 3.05829068586816 0.0483747478526861 no 506 0.0011130176457621 85 16462845
SGTC_2594 a-mangostin 100 µM 3.05125822380852 0.0487807657754631 no 507 0.00113942248494278 69 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_781 4335-2806 94.4 µM 3.03834167226532 0.0495335921448674 no 508 0.00118942035632138 50 845254
SGTC_222 nsc-310342 10.666 µM 3.03355592587419 0.0498148670609252 no 509 0.00120844954469083 18 432556
SGTC_2476 5806916 10.51 µM 3.02737315881153 0.050180134341052 no 510 0.00123344609994067 48 2870194
SGTC_155 k072-0202 43.6 µM 3.01834023423305 0.0507176187345433 no 511 0.00127081688668676 47 5857737
SGTC_544 k015-0020 52.4 µM 3.01057740399911 0.0511831831618161 no 512 0.00130375739162478 49 3008304
SGTC_1921 5740136 50 µM 2.99169615957975 0.0523297564376235 no 513 0.00138716118186952 118 1774243
SGTC_1241 0364-0022 50.8 µM 2.99071174646468 0.0523900903197062 no 514 0.00139164043752697 78 4563895
SGTC_2814 7977482 42.97 µM 2.98854915547588 0.0525228276967471 no 515 0.00140152703659446 112 6456762
SGTC_2931 9014674 55.67 µM 2.98655655152065 0.0526453676243278 no 516 0.00141069325060668 66 2996810
SGTC_3266 9136860 49.47 µM 2.98616234403548 0.0526696372135746 no 517 0.00141251312507485 89 4871271 YPR165W RHO1
SGTC_3013 9080133 71.4286 µM 2.98280472434659 0.0528767108395636 no 518 0.00142810081934446 64 17050193
SGTC_2811 7967822 32.47 µM 2.97952526264122 0.0530795871439821 no 519 0.0014434771170807 62 2232244
SGTC_1234 0326-0494 15.5 µM 2.97051484376377 0.0536401743445415 no 520 0.00148650518760109 52 1547813
SGTC_2388 9080168 200 µM 2.96928701651183 0.0537169259088914 no 521 0.0014924582609481 32 15943073
SGTC_855 0428-0020 25 µM 2.95084638675017 0.0548801448586881 no 522 0.0015845224141794 58 6812414
SGTC_153 4077-0274 519.67 µM 2.93868750665214 0.0556579454278668 no 523 0.00164802607733458 55 3121976
SGTC_1084 voriconazole 435 nM 2.93367367174149 0.0559812018546715 no 524 0.00167488095789516 72 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2706 st078239 82.5 µM 2.93119297019131 0.0561416865370888 no 525 0.00168831480608909 63 15434492
SGTC_2466 5983409 37.09 µM 2.92888554597481 0.0562912867975921 no 526 0.00170089829116702 61 2879657
SGTC_1378 2093-0007 380 nM 2.91065422745209 0.0574843785263286 no 527 0.00180336457182852 75 3618014
SGTC_1411 3909-8223 150 µM 2.9072007523032 0.0577126053749352 no 528 0.0018233953880093 42 X1411
SGTC_2804 7954240 19.48 µM 2.90235117856711 0.0580342970453541 no 529 0.00185186545177835 92 828705
SGTC_1828 st055811 49 µM 2.90113297680546 0.0581153262927893 no 530 0.00185908028782066 34 5877589
SGTC_667 1498-1044 59 µM 2.90022595183738 0.0581757151883574 no 531 0.00186446875531978 68 6739982
SGTC_1877 wortmannin 25 µM 2.89852450375068 0.0582891290244152 no 532 0.00187461505410778 157 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1844 rapamycin 4 nM 2.89113554029512 0.0587836729867532 no 533 0.00191926265471493 255 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2236 dapsone 200 µM 2.87692855136986 0.0597437949165782 no 534 0.00200783253834427 45 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_3185 9108267 49.47 µM 2.87270508776706 0.0600315773111661 no 535 0.00203486914696244 74 4910486
SGTC_1202 1988-0068 29.6 µM 2.8697883779898 0.060230951739015 no 536 0.00205373298212177 84 2850480
SGTC_58 0957-0393 9 µM 2.8689173033536 0.0602905952674797 no 537 0.00205939735675324 511 6997992
SGTC_1486 3970-0793 4.53 µM 2.86234181959296 0.0607423192884853 no 538 0.00210261554787733 40 2844330
SGTC_1774 st048371 48.465 µM 2.8615782395368 0.0607949469629291 no 539 0.00210768722729793 75 4242727
SGTC_2865 9030313 51.95 µM 2.85778767608393 0.0610567292505653 no 540 0.00213302870301175 61 42562754
SGTC_84 0443-0269 128.823 µM 2.84642908976809 0.0618464488718247 no 541 0.0022106287432727 69 6150058
SGTC_2089 5281248 129.67 µM 2.829551254592 0.0630345981446162 no 542 0.00233066665155024 82 2737878
SGTC_2918 7977171 22.06 µM 2.82227357405192 0.0635523791853084 no 543 0.00238422404640718 70 2236483
SGTC_2025 5147754 141 µM 2.82217185231426 0.0635596397077856 no 544 0.00238498045920086 46 315777 YLR208W SEC13
SGTC_117 lucigenin 22.078 µM 2.81144507985641 0.0643289063821834 no 545 0.00246597548469319 164 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2841 9004761 38.96 µM 2.78727907072575 0.066088461356348 no 546 0.00265763417531568 94 2991039
SGTC_2419 paclitaxel 166.5 µM 2.76935626792325 0.0674173508632108 no 547 0.00280835901779182 135 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1100 amiodarone 5.07 µM 2.7555756669517 0.0684530876332251 no 548 0.00292944755390591 65 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2482 5981709 142.65 µM 2.75456335367687 0.0685296534949788 no 549 0.00293852552851373 120 877755
SGTC_2297 7971671 152.32 µM 2.75253539945661 0.0686832356134897 no 550 0.00295678763630579 83 909016
SGTC_2766 oltipraz 83.91 µM 2.74929700654919 0.0689290375090428 no 551 0.0029861621326948 91 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2885 9057732 51.95 µM 2.74663784212952 0.0691313811007045 no 552 0.00301047894897234 69 6471414
SGTC_1469 k284-2957 126 µM 2.74568439400927 0.0692040431275623 no 553 0.00301924114257731 62 23884841
SGTC_1903 st060211 78.3 µM 2.72878448519141 0.0705017673401656 no 554 0.00317841165667535 99 688960
SGTC_2251 lansoprazole 556 µM 2.72876145165469 0.0705035487365542 no 555 0.00317863365438428 65 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_635 k038-0028 24.7 µM 2.72610658501587 0.0707091060471773 no 556 0.00320431500053879 128 4035102
SGTC_562 3772-2733 112 µM 2.72285348438549 0.0709616101118496 no 557 0.00323603769790068 160 2876874 YIL048W NEO1
SGTC_1161 k007-0610 110 µM 2.71444076268225 0.0716178127448869 no 558 0.0033193886098011 212 5843850
SGTC_2281 7943571 200 µM 2.69181611970327 0.0734056577881405 no 559 0.00355320573123359 59 1244024
SGTC_912 3474-0017 2.18 µM 2.67928131391722 0.0744107715138584 no 560 0.0036890189699239 96 3360550
SGTC_680 0417-1641 114 µM 2.67032866226142 0.0751350556579109 no 561 0.00378885171135628 73 2835990
SGTC_2994 9053520 71.4286 µM 2.66283622070405 0.0757453280636199 no 562 0.00387425587037996 80 4647384
SGTC_975 1335-0046 28.5 µM 2.66069289217966 0.0759205985766746 no 563 0.0038990023351057 134 16486740
SGTC_1512 0259-0544 12.2 µM 2.63800656332336 0.0777947494158475 no 564 0.00416974839004052 104 18476
SGTC_2106 5357045 167.29 µM 2.63689913291568 0.0778871268266511 no 565 0.00418338530799906 82 668842
SGTC_2144 5628481 200 µM 2.6324863152999 0.0782560532731635 no 566 0.00423812188074538 95 2818399
SGTC_430 0958-0115 16.4 µM 2.62361243623038 0.0790019494899874 no 567 0.00435013616379264 118 6833180
SGTC_1778 st046819 58.9 µM 2.61524279190526 0.0797103849354583 no 568 0.00445820244251494 115 671715
SGTC_2136 5328288 199.296 µM 2.59261107451255 0.0816500705978909 no 569 0.00476252090049537 83 262395
SGTC_1357 1503-1303 39.5 µM 2.59197232163162 0.081705327716249 no 570 0.0047713724372794 132 292895
SGTC_3158 9100007 49.47 µM 2.59160299548604 0.081737290175142 no 571 0.00477649707576322 83 19297233
SGTC_2584 androsterone 48.74 µM 2.58970507615121 0.0819016898051405 no 572 0.00480290942396049 275 2754130 A steroid.
SGTC_2287 7945887 168.79 µM 2.58924121611803 0.0819419076827169 no 573 0.00480938448985801 68 1245853
SGTC_1804 st050076 49.1 µM 2.58578527371415 0.0822420155186331 no 574 0.00485787181220851 104 3895976
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 2.58515982400544 0.0822964168016764 no 575 0.00486669336875748 86 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1563 conessine 56.1 µM 2.56432136645926 0.0841244648046514 no 576 0.00516888888959665 108 441082 An anti-amoebic, histamine inhibitor.
SGTC_360 0957-0399 1.01 µM 2.56308596237609 0.0842337898677392 no 577 0.00518731791648906 152 6752301 YPR165W RHO1
SGTC_1125 tnp00248 1.32998 µM 2.56208449683392 0.0843224911524723 no 578 0.00520230007286754 168 24207736
SGTC_1717 st033143 58.0435 µM 2.56048107016018 0.0844646549547378 no 579 0.00522636789105258 145 674616
SGTC_805 3852-0218 479 µM 2.55411493439093 0.0850308669927865 no 580 0.00532290545730233 163 6615355
SGTC_1186 1319-0216 26 µM 2.53267618648121 0.0869585812623659 no 581 0.00565977337588015 114 4565136
SGTC_1199 1638-0010 4.46 µM 2.53263323504562 0.0869624758379917 no 582 0.00566046685204976 123 3111136
SGTC_974 1326-0144 138 µM 2.53175638760675 0.0870420115285772 no 583 0.00567464056967558 144 5411856
SGTC_1423 4048-0112 5.59 µM 2.52703138945995 0.0874715346102405 no 584 0.00575156105376166 108 X1423
SGTC_1763 st044482 94.5 µM 2.52424367420182 0.0877256910577935 no 585 0.00579737636642348 107 88505
SGTC_892 0929-0076 29 µM 2.51896948414406 0.0882080462669386 no 586 0.005884942840657 160 5751038
SGTC_1097 itavastatin 7.23 µM 2.51239257691582 0.0888123087300118 no 587 0.00599578037058579 116 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_861 0443-0273 110 µM 2.51036584914121 0.0889991370026984 no 588 0.00603030688066533 103 6149169
SGTC_3124 9127567 49.47 µM 2.50989617355969 0.0890424744654455 no 589 0.00603833319048208 97 17592030
SGTC_2157 5649910 96.377 µM 2.50732331444216 0.0892801536201477 no 590 0.00608246913679165 119 2858091
SGTC_1419 3993-2473 62.6 µM 2.48148674716411 0.0916931409131992 no 591 0.00654177877551611 105 704026
SGTC_1760 st045453 10.4495 µM 2.4806256349906 0.0917743878380837 no 592 0.00655760180582473 232 3323419 YIL048W NEO1
SGTC_2072 5231554 129 µM 2.46936618128491 0.0928416422255021 no 593 0.00676763163261406 81 789545
SGTC_2363 9053361 176 µM 2.46839437277563 0.0929341858706272 no 594 0.00678603503453051 139 6469797 YMR079W SEC14
SGTC_792 4534-1957 155 µM 2.45565961933816 0.0941532030004413 no 595 0.00703131425331893 134 1717904
SGTC_1969 st069479 40.1 µM 2.44531869961813 0.0951517201198155 no 596 0.00723620959040351 92 3895485
SGTC_1028 k015-0029 4.8 µM 2.44018290582581 0.0956505200514247 no 597 0.00733991361024451 158 4588309
SGTC_1047 2043-3044 82 µM 2.42787534232945 0.0968536833110095 no 598 0.00759378122507335 153 669592
SGTC_1456 k015-0012 13 µM 2.42280415673303 0.0973526520491252 no 599 0.00770061350877433 144 2989616
SGTC_2904 7225135 42.03 µM 2.42224476871624 0.0974078071399959 no 600 0.00771247850418425 78 4446116
SGTC_1672 st016598 6.51 µM 2.42172222937986 0.0974593496919994 no 601 0.00772357644693395 198 4665860 YNL267W PIK1
SGTC_703 3875-0075 71.8 µM 2.40704894515461 0.0989148802979614 no 602 0.00804100717876822 79 2850814
SGTC_2659 sanguinarine 24.21 µM 2.38943520946091 0.100683018003753 no 603 0.00843714994644443 117 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2693 st077581 40.7 µM 2.38560059861791 0.101070988643267 no 604 0.00852562907680051 179 25238761
SGTC_1006 4099-6547 255 µM 2.37849655841076 0.101792624293041 no 605 0.00869169959803276 145 3146833
SGTC_18 0111-0177 500 nM 2.37369593984568 0.102282395110481 no 606 0.00880552313089176 216 721752
SGTC_1842 st055362 61.2 µM 2.37137933135665 0.102519353325231 no 607 0.00886091620792432 135 676032
SGTC_2403 6032726 181.2 µM 2.36774555825679 0.102891843539985 no 608 0.00894841961448599 157 2881040
SGTC_2877 9040724 71.43 µM 2.36621650958138 0.103048876596951 no 609 0.00898546572429849 110 6463895
SGTC_3156 9099931 49.47 µM 2.3617801588278 0.103505474196466 no 610 0.00909371195897112 118 18111053
SGTC_195 4234-0266 16.654 µM 2.36011848817509 0.103676873910021 no 611 0.00913454942444644 173 2303354
SGTC_1904 st060225 78 µM 2.35145220655023 0.104574130725838 no 612 0.00935014590229813 113 66595
SGTC_23 0213-0011 39.996 µM 2.34979586392983 0.104746257265168 no 613 0.00939185471809684 130 627608
SGTC_1984 st072354 53.1 µM 2.34568504448457 0.105174338463186 no 614 0.00949607426370646 113 5762938
SGTC_1012 4112-3522 18 µM 2.34520151476819 0.105224774043963 no 615 0.00950839917096995 138 3112398
SGTC_2224 6650123 117.647 µM 2.34490059534641 0.105256170908445 no 616 0.009516076500625 64 2908370
SGTC_1735 st034310 56.75 µM 2.34184537000334 0.105575326106066 no 617 0.00959433155160659 146 871153
SGTC_3208 9114115 49.47 µM 2.34010669577763 0.105757263775465 no 618 0.00963911576959704 161 650895
SGTC_3104 9120930 49.47 µM 2.33637965796678 0.106148030446541 no 619 0.00973573159191239 116 17014836
SGTC_3241 9133421 49.47 µM 2.32673628516067 0.107163942131336 no 620 0.00998965268737439 47 17018221
SGTC_2230 bromochlorosalicylanilide 954.5 nM 2.32655241249127 0.107183380664443 no 621 0.00999454990892589 69 77254
SGTC_3267 9137951 49.47 µM 2.3131294389621 0.108609296824279 no 622 0.0103577617909377 74 16643986
SGTC_380 3970-0968 6 µM 2.3112346933349 0.108811668599916 no 623 0.0104099475184528 138 2891601
SGTC_1446 4239-0190 62 µM 2.31038481588538 0.108902529344331 no 624 0.0104334294885895 181 1340085
SGTC_1699 st031318 29.054 µM 2.30728741424187 0.109234135429564 no 625 0.0105194013417941 128 5340658
SGTC_2214 7179297 48.276 µM 2.30432520347304 0.109551946140251 no 626 0.0106021975965512 83 769744
SGTC_259 usnic acid 108.925 µM 2.29334938103481 0.110735310961311 no 627 0.0109139491906471 157 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 2.29101775189073 0.110987872157291 no 628 0.0109811934858344 140 66535 A nucleotide analog.
SGTC_1487 3970-0795 2.82 µM 2.28874492919587 0.111234460314044 no 629 0.0110470884432069 135 3765103
SGTC_1629 st005085 44.9 µM 2.28792975521863 0.111322997488078 no 630 0.0110708060873008 187 24207091
SGTC_1785 bathophenanthroline 24 µM 2.28743126189141 0.111377164388622 no 631 0.0110853316589706 207 72812 An iron chelator.
SGTC_2683 piperine 63.03 µM 2.28671179346463 0.111455375974585 no 632 0.0111063254371127 109 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2381 9035592 200 µM 2.28529349256759 0.111609670962619 no 633 0.0111478121274829 141 4749657
SGTC_2934 9036370 36.88 µM 2.28500258651912 0.111641337106802 no 634 0.0111563380485288 183 6462800
SGTC_2055 5235184 200 µM 2.28409024460458 0.111740690414503 no 635 0.0111831138962515 168 2836034
SGTC_2434 5670830 169.91 µM 2.28147303435343 0.112026053431793 no 636 0.0112602353038141 163 1549830
SGTC_1123 mangostin 811.285 nM 2.2764923968098 0.112570547098194 no 637 0.0114082775788623 193 5281650 An antioxidant.
SGTC_2612 dictamnine 15.46 µM 2.27161462278068 0.11310562505461 no 638 0.0115548984537144 206 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2442 5158906 48.48 µM 2.26365490337085 0.113982676462493 no 639 0.0117976740926795 150 1893835
SGTC_3168 9103419 49.47 µM 2.24787970323072 0.115735179775699 no 640 0.0122919308682243 61 16649256
SGTC_1651 st011928 86.1 µM 2.24679826882343 0.115856015941915 no 641 0.01232646123036 135 720198
SGTC_1936 st074407 74.3 µM 2.24427022653933 0.11613884106362 no 642 0.0124075099941748 218 809813
SGTC_3350 9150499 3.57 µM 2.2342791526369 0.117261388170775 no 643 0.012732355583335 218 4910996 YPR165W RHO1
SGTC_2514 salinomycin 42.74 µM 2.23420547416223 0.11726969476301 no 644 0.012734778211089 218 23682228 A polyether potassium ionophore.
SGTC_910 3454-3003 490 µM 2.23325648451026 0.117376722157005 no 645 0.0127660176844469 171 820824
SGTC_2234 tolnaftate 200 µM 2.23323857454883 0.117378742713738 no 646 0.0127666078933482 56 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1957 st077035 62.4 µM 2.22972011364634 0.117776164452184 no 647 0.0128830148638193 130 705593
SGTC_1548 st061468 90.8 µM 2.21710184028359 0.119209267900321 no 648 0.0133080665396521 116 390799
SGTC_2502 avocadyne acetate 18.59 µM 2.21706066548996 0.119213964332228 no 649 0.013309473122274 199 3952079
SGTC_1145 3546-0597 10.2 µM 2.20395896063526 0.120714993489304 no 650 0.0137636151966008 183 875334
SGTC_3065 9113888 49.47 µM 2.19817705253698 0.121381625674196 no 651 0.0139682456457754 154 16648368
SGTC_2372 9071633 200 µM 2.19481506308028 0.12177043835721 no 652 0.0140884332607497 142 21321366
SGTC_375 3970-0961 9.27 µM 2.19434587611689 0.121824769138508 no 653 0.0141052768666782 171 2898222
SGTC_1263 0774-1208 64.8 µM 2.1892315571391 0.122418100350559 no 654 0.0142900070423741 245 906585
SGTC_189 3970-0742 2.116 µM 2.18073923076447 0.123407800760693 no 655 0.0146013547994412 110 2891807
SGTC_1159 4092-0538 61.2 µM 2.17675282519334 0.123874306653185 no 656 0.0147495072870576 187 717301
SGTC_463 ikarugamyin 104 µM 2.17675188989871 0.123874416249924 no 657 0.0147495421979068 72 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2906 7926292 26.41 µM 2.17390764217771 0.124208015872836 no 658 0.0148560360034367 197 2966319
SGTC_2232 chlorophetanol 41.5365 µM 2.17027156808955 0.124635402745977 no 659 0.0149931395863691 310 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1225 1216-0074 20.6 µM 2.16993722390175 0.124674753355192 no 660 0.0150058009598938 181 4241466
SGTC_1518 st038567 90.8 µM 2.1698447827432 0.124685634741239 no 661 0.015009303261322 141 77966
SGTC_1311 1190-0148 100 µM 2.16791275132634 0.124913208948621 no 662 0.0150826627432442 210 1961333
SGTC_2842 9000675 19.48 µM 2.16706721658446 0.125012895818283 no 663 0.0151148646098344 177 2989072
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 2.16636871178294 0.12509529005449 no 664 0.0151415114406943 151 229346 A bile salt which induces apoptosis.
SGTC_1157 4092-0394 27.6 µM 2.16204736875234 0.125605870186337 no 665 0.0153072626014261 206 3659885
SGTC_2383 9036125 200 µM 2.16003965741462 0.125843581586984 no 666 0.0153847998358259 109 79580
SGTC_514 4466-0038 2.65 nM 2.15550702368436 0.126381395039508 no 667 0.0155610897974789 363 5722064
SGTC_1421 4029-0249 71.4 µM 2.15490599621165 0.126452829210528 no 668 0.0155845955367716 195 2894095
SGTC_1476 4112-3294 3.34 µM 2.15252911924416 0.126735604737209 no 669 0.0156778521868506 147 704369
SGTC_777 1315-0167 517 µM 2.15073505749289 0.126949334511692 no 670 0.0157485587991531 172 4221767
SGTC_1000 4048-0884 8.67 µM 2.15004720595259 0.127031345989526 no 671 0.0157757404884432 193 13040088
SGTC_2809 7964133 12.99 µM 2.14850078109821 0.127215858449452 no 672 0.0158369972035613 231 1253665
SGTC_1979 st071809 45.3 µM 2.1465741975618 0.127445990467963 no 673 0.0159135979572696 153 4976333
SGTC_2397 5161689 200 µM 2.14622314172097 0.127487955546088 no 674 0.0159275900611546 204 2259942
SGTC_1520 flindersine 88 µM 2.14172851054974 0.128026091146738 no 675 0.0161076675430251 196 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_329 k048-0121 21.3 µM 2.13782156207051 0.128495144677813 no 676 0.0162656141504168 172 6832902
SGTC_1556 plumbagin 1.48 µM 2.13553090435262 0.128770706446513 no 677 0.0163588342959264 133 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_122 0236-0016 402.397 µM 2.12823248884633 0.129651424886414 no 678 0.0166589061921547 240 6808838
SGTC_294 k038-0071 157 µM 2.1280184745772 0.129677313347396 no 679 0.0166677759290321 241 24152826
SGTC_2273 7815444 169.05 µM 2.12519337407185 0.130019390191333 no 680 0.0167852403490725 177 2824616
SGTC_2772 vinpocetine 57.06 µM 2.11927780887748 0.130737697308403 no 681 0.0170334979566881 204 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2808 7946468 45.46 µM 2.103307835871 0.132690559088528 no 682 0.01771943446389 224 2970879
SGTC_1581 himbacine 57.9 µM 2.1001654240304 0.133077177307919 no 683 0.0178571458827814 227 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1067 clotrimazole 1.36 µM 2.08947840306604 0.134397825172214 no 684 0.0183323400323235 219 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1359 1582-0056 520 nM 2.08792005759877 0.134591146779061 no 685 0.0184025232704335 216 3661189
SGTC_1817 st052116 64.4 µM 2.08717695238621 0.134683400378359 no 686 0.0184360710206471 174 4361398
SGTC_2940 9060638 45.86 µM 2.08175458138724 0.135357880043176 no 687 0.0186824461401464 217 4027022
SGTC_1860 st056228 74.6 µM 2.08148447814594 0.135391538160697 no 688 0.0186947916917565 185 688679
SGTC_2792 7535235 81.82 µM 2.07088558890682 0.136716817535502 no 689 0.0191847446100592 202 1281891
SGTC_2601 securinine 100 µM 2.06937951306991 0.136905853677264 no 690 0.019255243724709 208 442872 A GABA receptor antagonist.
SGTC_2306 7482397 179.52 µM 2.06365518419179 0.137625976067974 no 691 0.0195252106765763 202 891448
SGTC_2400 5203494 178.7 µM 2.06028491585843 0.138051163941356 no 692 0.0196856555485042 196 6777674
SGTC_3251 9135047 49.47 µM 2.05891099550497 0.138224752395389 no 693 0.0197513827822612 134 17682963
SGTC_2242 6630449 61.2675 µM 2.05385252359085 0.138865149025807 no 694 0.019994983787411 208 691249 YDR170C SEC7
SGTC_744 1594-0068 283 µM 2.05142963978343 0.139172597780003 no 695 0.020112562536406 252 668392
SGTC_197 4544-0043 41.561 µM 2.04773586572813 0.139642205421309 no 696 0.0202929437653515 260 896523
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 2.04427332566406 0.140083392497818 no 697 0.02046327643019 207 6312947
SGTC_1015 4130-4525 82 µM 2.03889565732063 0.140770475596973 no 698 0.0207302212132686 199 1363237
SGTC_549 1661-1316 519 µM 2.03402086793854 0.141395280664873 no 699 0.0209747457439966 200 2857282
SGTC_2880 9042983 58.44 µM 2.03329163099683 0.141488908821066 no 700 0.0210115340994754 207 6464714
SGTC_2848 9016370 25.97 µM 2.03001727380021 0.141909827683002 no 701 0.0211773917361446 224 7894410
SGTC_2715 st079500 56.4 µM 2.02665859041542 0.142342466726583 no 702 0.0213486700626183 178 28246688
SGTC_830 4076-0286 57.8 µM 2.02618930139943 0.142402987804165 no 703 0.0213726947828152 379 6866659
SGTC_1743 st037606 46.3785 µM 2.01445984658149 0.143921312898224 no 704 0.0219806382544534 236 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_404 fumagillin 50 µM 2.00903112042205 0.144627720284445 no 705 0.0222669167379662 225 12015870 A methionine aminopeptidase binder.
SGTC_966 1300-0360 30.2 µM 2.00508126995962 0.145143156012294 no 706 0.0224771797424827 223 70588
SGTC_1358 1509-0022 2.48 µM 2.00361426907723 0.145334906740679 no 707 0.0225556980745008 203 3258434
SGTC_1046 2001-0062 216 µM 1.99774922105874 0.146103225407504 no 708 0.0228719275051073 226 739778
SGTC_2474 5321570 43.32 µM 1.99358904865452 0.146649857280017 no 709 0.023098491573028 186 2841384
SGTC_3224 9130643 49.47 µM 1.98971840301473 0.147159677318352 no 710 0.0233109821494246 243 17644395
SGTC_3077 9117319 49.47 µM 1.97899621221654 0.148578143261887 no 711 0.0239082163641221 171 17154678
SGTC_307 1501-1223 22.3 µM 1.97791135738651 0.148722169019626 no 712 0.0239693537390567 197 2830329
SGTC_724 3910-0327 137 µM 1.96561050560816 0.150361761855996 no 713 0.0246718098172178 232 2885483
SGTC_2228 7354201 200 µM 1.95474247785338 0.151820356744363 no 714 0.0253067368223574 159 753451
SGTC_1654 st012436 41.8 µM 1.95417271194127 0.151897083353673 no 715 0.0253403976526591 190 4323132
SGTC_1985 st071382 65.5 µM 1.950977474688 0.152327842081992 no 716 0.0255298626955851 222 6123237
SGTC_465 cgp-37157 41 µM 1.94788629789732 0.152745343093906 no 717 0.0257142848372199 142 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2279 7948423 32.93 µM 1.94746536538186 0.15280225380463 no 718 0.0257394840672542 190 1247112
SGTC_1336 1486-0901 104 µM 1.9441306677645 0.153253606886761 no 719 0.025939847940925 239 5006114
SGTC_3120 9124077 49.47 µM 1.94231213418506 0.15350011823019 no 720 0.0260496624731881 190 18774327 YGL155W CDC43
SGTC_3191 9110352 49.47 µM 1.93477454843717 0.154524674462039 no 721 0.0265089838212134 188 17122424
SGTC_2643 anethole 100 µM 1.93286885328363 0.154784422808937 no 722 0.0266261778382883 255 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_640 3381-0960 37.1 µM 1.93235871150346 0.154854004611058 no 723 0.0266576232212885 241 1745025
SGTC_1156 4092-0367 4.88 µM 1.92654993975334 0.15564776051473 no 724 0.0270178712353537 255 1357585
SGTC_1127 asiatic acid 681.4 nM 1.92650125989977 0.155654423828253 no 725 0.027020907342904 254 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1312 1218-2183 165 µM 1.91305237677287 0.157502517337671 no 726 0.0278706737803698 218 6744073
SGTC_1788 fluconazole 20 µM 1.91295944349052 0.157515337831052 no 727 0.027876622330435 275 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2850 9015429 58.44 µM 1.90815191135692 0.158179490166661 no 728 0.0281857924524949 242 6457570
SGTC_3342 9147791 14.508 µM 1.90305718673057 0.158885320563067 no 729 0.0285165418099492 235 1838168
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 1.90036597088854 0.15925899732727 no 730 0.0286925546853893 262 16486 A toxic proline analog.
SGTC_3046 9092212 49.47 µM 1.89977807837091 0.159340703053942 no 731 0.0287311244547731 209 25236637
SGTC_3225 9130819 49.47 µM 1.89502442482204 0.160002377342296 no 732 0.0290445829406069 249 4547121
SGTC_2334 9017922 200 µM 1.89072407357553 0.160602500971392 no 733 0.0293305935709108 229 3163164
SGTC_2188 6126565 140.678 µM 1.88908027951127 0.160832284008239 no 734 0.0294405362290907 188 874518
SGTC_37 0566-0070 1.56 µM 1.88199728087911 0.161824857522778 no 735 0.0299181924138943 286 1626686
SGTC_1267 0828-0272 9.49 µM 1.88198940015935 0.161825964102934 no 736 0.0299187274244723 261 745334
SGTC_1163 k060-0048 49.9 µM 1.88137157403582 0.161912732200193 no 737 0.0299606954421268 286 6809982
SGTC_458 nppb 133 µM 1.87623711336459 0.162634993158461 no 738 0.0303113639838379 215 4549 A chloride channel blocker.
SGTC_2227 7312221 64.1025 µM 1.86490311969972 0.164236746182458 no 739 0.0310974925427536 155 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1824 st053723 68.6 µM 1.86468189398527 0.164268111891145 no 740 0.0311130030772457 268 675225
SGTC_319 1348-1596 45.5 µM 1.85639709897469 0.165445538477763 no 741 0.0316984889680546 258 5380505
SGTC_215 1287-0124 461.5 µM 1.84971771147407 0.166398771422733 no 742 0.0321771231953394 166 5560863
SGTC_2316 5844804 197.44 µM 1.84415370365855 0.167195527490146 no 743 0.0325803716080579 365 776813
SGTC_1725 st036284 20.55 µM 1.84387962010999 0.167234839223699 no 744 0.0326003428978397 303 707914
SGTC_3159 9100096 49.47 µM 1.84243800070133 0.167441708403791 no 745 0.0327055537891211 267 25236875
SGTC_79 0052-0007 94.094 µM 1.84066262801043 0.167696696895287 no 746 0.0328355068931677 271 2801472
SGTC_1439 4092-1168 46 µM 1.83083612097718 0.169112551744394 no 747 0.0335625035882474 247 2886240
SGTC_921 1561-0023 372 µM 1.82672162831281 0.169707662864433 no 748 0.0338708173127149 273 24050882
SGTC_588 3970-1144 52.9 µM 1.81850341079444 0.170900343102381 no 749 0.0344936129409091 294 1888707
SGTC_536 3852-0578 10.6 µM 1.81388629093263 0.171572756176765 no 750 0.0348476168739874 262 2869208
SGTC_972 1319-0219 195 µM 1.80553148984562 0.172793796099291 no 751 0.0354957762279435 286 23903702
SGTC_772 k072-0172 35.3 µM 1.79536425366246 0.174287171938664 no 752 0.036297841942373 261 5861980
SGTC_2987 9018338 71.43 µM 1.79162985857121 0.174837737514186 no 753 0.0365961384659357 307 5055682
SGTC_523 1934-0222 13.7 µM 1.78954450851113 0.175145662527619 no 754 0.0367635830826788 308 1361595
SGTC_1118 chelidonine 707.474 nM 1.78665199353975 0.175573343466351 no 755 0.0369968763196649 304 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1307 1187-1599 12.2 µM 1.78525681695962 0.17577986762328 no 756 0.0371098349154459 283 1538471
SGTC_2733 amorolfine 100 µM 1.78380325089904 0.175995198625872 no 757 0.0372278205771851 146 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3312 9133330 71.43 µM 1.78030679806091 0.176513846220509 no 758 0.0375128825994787 267 17617324
SGTC_2023 5144124 124 µM 1.77958661645351 0.176620794566319 no 759 0.0375718190519107 286 2830192
SGTC_1238 0333-0287 48.8 µM 1.77578115427281 0.177186593072811 no 760 0.0378844975505289 282 7226
SGTC_1694 st024011 44.9 µM 1.77263886534033 0.177654652502553 no 761 0.0381442836358796 319 2787533
SGTC_1498 4478-3555 97.6 µM 1.77081375488083 0.177926869546279 no 762 0.0382958389237243 213 3437919
SGTC_2978 9011784 42.97 µM 1.77068058962551 0.177946741568128 no 763 0.0383069160199395 364 2994934
SGTC_656 4090-1979 187 µM 1.76937643016454 0.178141433008599 no 764 0.0384155381514605 328 22330961
SGTC_2126 5251174 33.877 µM 1.7663233998773 0.178597729480525 no 765 0.0386708039997379 383 790722
SGTC_3313 9133968 57.047 µM 1.76491491046798 0.178808485846192 no 766 0.0387890336840126 315 1494643
SGTC_509 pifithrin 175 µM 1.75372291976473 0.180488736280582 no 767 0.0397389981361571 244 4817 A p53 inhibitor.
SGTC_1425 4048-4433 7.33 µM 1.75323287697333 0.180562531883519 no 768 0.0397810209154003 323 23734946
SGTC_2184 6075246 200 µM 1.74433292538607 0.181906067917475 no 769 0.040550526767314 295 2267320
SGTC_663 1486-0733 13.9 µM 1.74403727302075 0.181950806610132 no 770 0.0405762953227422 378 722445 YPR165W RHO1
SGTC_2252 omeprazole 400 µM 1.74219399606675 0.182229890031042 no 771 0.0407372521085026 190 4594 A proton pump inhibitor.
SGTC_2844 9010103 25.97 µM 1.73753336366786 0.1829367309144 no 772 0.0411465351358124 344 2480525
SGTC_1951 sophoraflavanone G 9.2 µM 1.73667096041796 0.183067712069677 no 773 0.0412226331779624 332 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_775 4577-0580 57.3 µM 1.72994881031528 0.184090671554015 no 774 0.0418197107249146 294 2006902
SGTC_413 propylparaben 100 µM 1.72739507599692 0.184480223160654 no 775 0.042048367177264 278 7175 A pharmaceutical preservative.
SGTC_1076 itraconazole 331 nM 1.72421966972924 0.184965320380536 no 776 0.0423340972648028 314 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2537 larixol 68.93 µM 1.72177684219677 0.185339042647824 no 777 0.042554975578568 335 6708759
SGTC_2988 9073640 71.4286 µM 1.71607345573116 0.186213413346366 no 778 0.0430742994282656 299 9102229
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.71471513893853 0.186422029503858 no 779 0.0431987332942916 329 2333 A French combination drug.
SGTC_2270 7924575 90.91 µM 1.71354732771185 0.186601502683018 no 780 0.0433059471148818 314 1262135
SGTC_2714 st079313 56.9 µM 1.71137472722323 0.186935679821061 no 781 0.0435059797587307 287 2939799
SGTC_1355 1499-0035 1.68 µM 1.71109718047505 0.186978397152767 no 782 0.043531587292832 318 1548538
SGTC_1489 4065-0444 182 µM 1.70666955131479 0.187660671762882 no 783 0.0439417448606946 284 2877968
SGTC_303 1348-1668 34.2 µM 1.70407150794022 0.188061731811285 no 784 0.0441838644014575 291 5380509
SGTC_1618 st003135 44.5 µM 1.70269891224405 0.18827383288925 no 785 0.0443122142752518 277 1270615
SGTC_2299 7976368 114.88 µM 1.70056083788925 0.188604513825107 no 786 0.0445127416120735 303 2979718
SGTC_1768 st044301 37.178 µM 1.69978964750652 0.188723876241165 no 787 0.0445852497540297 327 3931349
SGTC_510 ag-490 170 µM 1.69911831936501 0.188827820193133 no 788 0.0446484461726606 274 5328779
SGTC_1852 st056254 31.4 µM 1.69181062738222 0.189961575209168 no 789 0.0453410433222045 306 442583
SGTC_2556 citropten 84.59 µM 1.69146282833014 0.190015638756903 no 790 0.0453742207229304 374 2775 A potential DNA crosslinker.
SGTC_842 0271-0008 11.1 µM 1.68697696300904 0.190713790475134 no 791 0.045803890857533 347 1221709
SGTC_1107 amlodipine 47 µM 1.68331148776047 0.19128542899806 no 792 0.0461574038521826 347 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_542 3381-0244 89.3 µM 1.68132706321355 0.191595341884597 no 793 0.0463497019854316 375 1112843
SGTC_2604 4'-hydroxychalcone 11.32 µM 1.68036013759732 0.191746460620594 no 794 0.0464436334582351 323 5282362
SGTC_2293 7624732 200 µM 1.67897765283045 0.191962652944503 no 795 0.046578199558198 313 894453
SGTC_227 fluconazole 33.516 µM 1.6732162382572 0.192865225594261 no 796 0.0471423673965378 412 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_692 k241-0027 77.8 µM 1.66040364851468 0.194881694307151 no 797 0.0484166383292372 324 3600480
SGTC_1323 1348-1351 11.2 µM 1.65970992105718 0.19499123905467 no 798 0.0484864112799106 296 6989654
SGTC_2722 naftopidil 47.16 µM 1.6596582518248 0.194999399510178 no 799 0.0484916112263196 328 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1288 0973-0013 65.5 µM 1.65592792982698 0.195589101849748 no 800 0.0488682073600283 347 4315430
SGTC_2524 avocatin b 10.57 µM 1.65313716925885 0.196030982302465 no 801 0.0491514750905329 304 6710748
SGTC_3084 9116877 49.47 µM 1.65302372814537 0.196048957018568 no 802 0.0491630172671828 269 27241325
SGTC_2735 sertaconazole 140 nM 1.65205339358418 0.196202747131834 no 803 0.0492618333731761 252 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2825 7998094 58.44 µM 1.65117686129939 0.196341733216547 no 804 0.0493512332044582 347 2987815
SGTC_261 5-fluorouridine 15.376 µM 1.6510910636257 0.196355340807678 no 805 0.0493599908901476 337 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1392 3455-1037 33.9 µM 1.65016746052204 0.196501861318757 no 806 0.0494543450618065 335 981132
SGTC_472 calcifediol 10 µM 1.64992157580674 0.196540879664404 no 807 0.0494794885967662 273 5283731 A vitamin D metabolite.
SGTC_296 1222-0039 74.9 µM 1.64783039694613 0.1968729091825 no 808 0.0496937397638659 343 5984176
SGTC_1663 st014140 55.4 µM 1.64354258697539 0.197554772770637 no 809 0.0501353608069612 394 4207120
SGTC_3319 9138450 16.7555 µM 1.64277686988285 0.197676690039843 no 810 0.0502145537611337 323 2029690
SGTC_3309 9129340 25.759 µM 1.64173633154642 0.197842437136704 no 811 0.0503223294014068 356 17158987
SGTC_2028 5153890 36.43 µM 1.64129623720121 0.197912564915464 no 812 0.0503679684075797 346 2830968 YPR165W RHO1
SGTC_2303 7774051 200 µM 1.63928382481649 0.198233428357531 no 813 0.0505770815657192 333 2953184
SGTC_2930 9013230 14.89 µM 1.63741421660824 0.198531803982004 no 814 0.0507719748461375 399 2995857
SGTC_794 k038-0031 316 µM 1.63290978132704 0.199251790277877 no 815 0.0512439863268228 456 6624242
SGTC_1196 1588-0294 184 µM 1.62950321324497 0.199797337016424 no 816 0.0516032676053676 326 6144269
SGTC_2926 9010726 65.15 µM 1.62157923454662 0.20106979782223 no 817 0.0524467359290923 378 2994293
SGTC_2670 beta-carotene 100 µM 1.61789560187921 0.201662980001779 no 818 0.0528425491417963 257 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_82 0054-0107 293.755 µM 1.616051475943 0.201960336330718 no 819 0.0530415921015774 317 3104697
SGTC_3014 9081533 49.47 µM 1.61150950301255 0.202693825717422 no 820 0.0535343588201079 355 21367265
SGTC_2644 guaiazulene 100 µM 1.60967173390879 0.20299106135086 no 821 0.0537347694261879 312 3515 A coloring agent.
SGTC_1384 3089-0840 101 µM 1.60771268864979 0.203308198308392 no 822 0.0539490591451159 326 1069836
SGTC_2743 auranofin 4.32 µM 1.60656417664481 0.203494260769932 no 823 0.0540750031065844 340 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2053 5265679 138 µM 1.6063341096935 0.203531544527986 no 824 0.0541002598302661 386 764595
SGTC_726 3448-4391 34.2 µM 1.60610877335222 0.203568065610997 no 825 0.0541250062778494 390 1356692
SGTC_3019 9081971 49.47 µM 1.60228039648051 0.20418914168632 no 826 0.0545468093255982 351 16451803
SGTC_1373 2887-0003 58.5 µM 1.60182067949346 0.204263797209713 no 827 0.0545976343872251 371 776948
SGTC_131 0141-0277 33.849 µM 1.60052430562409 0.204474408754337 no 828 0.0547411596713391 389 1547771
SGTC_2012 4023501 200 µM 1.5988477561743 0.204746975969336 no 829 0.0549272174032132 355 3477460
SGTC_2774 tamoxifen 10.92 µM 1.59744929121806 0.204974498463476 no 830 0.0550827962561237 367 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_92 0063-0024 660.874 µM 1.5919124333164 0.205876789020546 no 831 0.0557021907416752 400 3594437
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.59052665114476 0.20610298526446 no 832 0.0558580715674046 373 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1189 1431-2119 7.28 µM 1.59026881646921 0.206145086945316 no 833 0.0558871122467251 422 3107275
SGTC_693 4161-2696 114 µM 1.58940953651233 0.206285435100499 no 834 0.0559839814829969 305 805759
SGTC_3244 9134489 49.47 µM 1.58795056670119 0.206523861636963 no 835 0.0561487588555536 363 16584271
SGTC_3189 9110682 49.47 µM 1.58760461073045 0.206580422096854 no 836 0.0561878874749655 373 17122418
SGTC_2034 5197015 53.07 µM 1.58456525597971 0.207077721483711 no 837 0.0565325720974056 367 780676
SGTC_850 0388-0143 75.9 µM 1.57808553925156 0.208140294633394 no 838 0.0572729799296329 361 67273
SGTC_3113 9123498 49.47 µM 1.57377449020678 0.208849019016245 no 839 0.0577697967866865 351 8897275
SGTC_2731 amoxapine 43.43 µM 1.57314491283659 0.208952638624187 no 840 0.0578426336745519 202 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_302 1094-0063 18.9 µM 1.57212587070003 0.209120422834455 no 841 0.0579606813858847 319 5440289
SGTC_1131 3454-3128 32.3 µM 1.57021354448616 0.20943549935354 no 842 0.0581827197678243 445 710982
SGTC_1790 st045711 43.5 µM 1.56980291692298 0.209503191114922 no 843 0.0582304843872568 385 585119
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.56963882203488 0.209530245679395 no 844 0.0582495806855748 365 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2990 9074105 71.4286 µM 1.56698477966675 0.209968106888982 no 845 0.0585591246467827 342 6502001
SGTC_3122 9126309 49.47 µM 1.56629005864304 0.210082809990554 no 846 0.0586403636490016 342 17591206
SGTC_3242 9133940 49.47 µM 1.56106518905381 0.210946649845164 no 847 0.0592541852736841 368 17248444
SGTC_138 0850-0259 40.9225 µM 1.55942071958635 0.21121896409131 no 848 0.0594484177336852 569 6813004
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.55710455412825 0.211602856297599 no 849 0.0597228319877435 483 551469
SGTC_1166 k206-0078 225 µM 1.54960192729859 0.212849178155195 no 850 0.0606185450489897 427 5404595
SGTC_1165 k072-0275 30.3 µM 1.54922861206122 0.212911304257865 no 851 0.0606633868534261 372 6153523 YGL055W OLE1
SGTC_2338 7999974 200 µM 1.54707882070181 0.213269272548437 no 852 0.0609221201647699 420 315925
SGTC_3032 9089427 49.47 µM 1.54627382516791 0.213403405056748 no 853 0.0610192253145637 368 17173707
SGTC_3215 9129942 49.47 µM 1.54031425830538 0.214397947341046 no 854 0.0617418849507356 342 17682944
SGTC_2648 atorvastatin 78.68 µM 1.54005243429842 0.21444170268222 no 855 0.0617737864066756 353 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1408 3909-7976 48.8 µM 1.53965787447196 0.214507650292737 no 856 0.0618218851142687 449 24152374
SGTC_3192 9110362 49.47 µM 1.53829366811626 0.214735757632733 no 857 0.0619884136157316 402 16649480
SGTC_1313 1220-0047 237 µM 1.53364579866269 0.215513979793059 no 858 0.0625584073628718 458 3528706
SGTC_1301 naphtanilide LB 4.81 µM 1.52746919669303 0.216550694396226 no 859 0.0633221906018404 423 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_983 1491-0821 12.2 µM 1.52296193059998 0.217309036105567 no 860 0.0638841150419006 367 46495113
SGTC_2653 dihydrofissinolide 100 µM 1.52102358597984 0.217635631092669 no 861 0.0641269592925348 351 6857746
SGTC_1344 1488-0097 29.1 µM 1.5175945642384 0.218214085996228 no 862 0.0645583190162615 397 747966
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.51494669618531 0.218661370638608 no 863 0.064892951752666 486 688788
SGTC_2878 9043973 25.97 µM 1.51357278652845 0.218893662771866 no 864 0.0650671137708643 365 6465167
SGTC_819 1013-0258 27.7 µM 1.51163735795087 0.219221133779093 no 865 0.0653130712528645 433 5753198
SGTC_1644 st010134 20.9 µM 1.51146450399303 0.219250394047801 no 866 0.0653350728582684 365 3818134
SGTC_1863 st057641 20.1 µM 1.51074829527061 0.219371655916585 no 867 0.0654262962958379 444 3921635
SGTC_3288 9119690 36.221 µM 1.50585745472459 0.220200757503354 no 868 0.0660518851761734 371 17595618 YKL019W RAM2
SGTC_1741 st038134 10.228 µM 1.49944378519825 0.221290729571837 no 869 0.0668792709294174 466 1272587
SGTC_2280 7785178 200 µM 1.49785926086773 0.221560486382115 no 870 0.0670849100802391 380 2954328
SGTC_1898 st060199 18.6 µM 1.49445527661352 0.222140631670458 no 871 0.067528331517 399 688866
SGTC_119 0121-0043 24.815 µM 1.48998395817797 0.222903999850291 no 872 0.0681142269850852 627 1092378
SGTC_3137 9097352 49.47 µM 1.48384511422228 0.223954487487756 no 873 0.068925007734668 471 44120435
SGTC_929 2805-0021 398 µM 1.47865895038847 0.224844138962173 no 874 0.0696157443389119 417 3098024
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.47781274114632 0.224989490357359 no 875 0.0697289535524886 474 688664
SGTC_1327 1436-0082 2.18 µM 1.4685083380539 0.226591193690264 no 876 0.0709830965127008 421 15992205
SGTC_970 1315-0089 19.5 µM 1.4653969863144 0.227128228875914 no 877 0.0714063195980528 410 6811083 YLR033W RSC58
SGTC_1278 0874-0585 172 µM 1.46518688300044 0.227164519623445 no 878 0.0714349686577696 436 766306
SGTC_1382 3002-2117 298 µM 1.46165592360442 0.227774904367014 no 879 0.0719177606266388 453 1497314
SGTC_2166 5933061 31.504 µM 1.46165529477641 0.227775013152482 no 880 0.0719178468292692 441 2877375
SGTC_801 0866-0028 10.1 µM 1.46126015353458 0.227843377252086 no 881 0.0719720302737644 476 6849771
SGTC_27 0485-0001 32.618 µM 1.46048889702206 0.227976846989484 no 882 0.0720778784031274 319 2054479
SGTC_1843 st055809 45.5 µM 1.46003310277051 0.228055745100747 no 883 0.0721404882076527 419 16413835
SGTC_1572 epiandrosterone 68.9 µM 1.45334893459112 0.229214538816548 no 884 0.0730634485285747 476 441302 A steroid.
SGTC_816 0325-0417 81.3 µM 1.44695604258217 0.230325918075155 no 885 0.073954617679562 411 68101
SGTC_696 1560-0013 611 µM 1.44020977962565 0.231501990071098 no 886 0.0749040285977592 465 1650269
SGTC_2359 9039622 200 µM 1.43736251240359 0.23199935534173 no 887 0.0753075074135051 471 6463596
SGTC_2433 5607874 27.82 µM 1.43657426627434 0.232137152539521 no 888 0.075419500014463 468 2252428
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.43591043993151 0.232253234627865 no 889 0.075513913698557 477 688751
SGTC_3324 9138759 60.749 µM 1.43540162080157 0.23234223275326 no 890 0.0755863422058442 450 45595710
SGTC_615 k087-0205 167 µM 1.42930758802288 0.233409619933393 no 891 0.0764579230073209 443 9642773
SGTC_2945 9067681 61.76 µM 1.42678387030225 0.233852451577638 no 892 0.0768211009155892 423 16456930
SGTC_2849 9019321 12.99 µM 1.42385993494521 0.2343660902441 no 893 0.0772435108639548 443 16489627
SGTC_2616 abietic acid 100 µM 1.42028845889038 0.234994326524075 no 894 0.0777618598581714 498 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1316 1272-0050 65.9 µM 1.41887459213034 0.23524328792751 no 895 0.0779677904770454 457 7340392
SGTC_113 0099-0221 2.5 µM 1.41655694911103 0.235651706044281 no 896 0.0783062514183049 435 89219
SGTC_880 0833-0487 87.2 µM 1.41077746188667 0.23667187650037 no 897 0.0791551210460027 466 76075
SGTC_1025 k007-0731 70 µM 1.40732136905991 0.237283090151238 no 898 0.0796660578027108 449 6256118
SGTC_330 1488-0319 80.1 µM 1.40730880687705 0.237285313366616 no 899 0.0796679194924345 456 6846614
SGTC_1073 triclabendazole 3.09 µM 1.40656212812462 0.237417478756484 no 900 0.0797786348793995 555 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_832 4083-0019 164 µM 1.40629786446 0.237464264256895 no 901 0.0798178470093632 677 1990758
SGTC_2959 9079155 11 µM 1.40048674808219 0.238494348289284 no 902 0.0806838045060477 420 16189457
SGTC_2563 tomatine 8.54 µM 1.40014059023434 0.238555785663451 no 903 0.0807356110858416 560 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1569 carminic acid 40.6 µM 1.39932594593033 0.238700405922677 no 904 0.0808576312686147 482 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3273 9137859 49.47 µM 1.39886629407883 0.238782027081189 no 905 0.0809265408931743 425 2377234
SGTC_2051 5263410 176 µM 1.39873403477935 0.238805515417483 no 906 0.0809463770208109 489 227584
SGTC_3176 9106582 49.47 µM 1.39852019894917 0.238843493854501 no 907 0.0809784556847558 297 17018027
SGTC_1334 1486-0610 236 µM 1.39605195328504 0.239282107111305 no 908 0.0813494254036825 495 3742339
SGTC_1856 st057054 55.7 µM 1.39442076099293 0.239572215275743 no 909 0.0815952911940805 493 1266018
SGTC_3279 9140807 49.47 µM 1.39376236041994 0.239689366434598 no 910 0.0816946889327573 465 45595718
SGTC_3036 9090181 49.47 µM 1.3923468130772 0.239941344783868 no 911 0.081908701032534 447 25236586
SGTC_2022 5136654 200 µM 1.39170503056245 0.240055634602429 no 912 0.0820058691728878 480 1713771
SGTC_3219 9131112 49.47 µM 1.38851835538342 0.240623562933965 no 913 0.0824896296926887 461 17612988 YMR079W SEC14
SGTC_171 k064-0041 9.68 µM 1.3880981794101 0.240698501115741 no 914 0.0825535754485026 386 53325
SGTC_2824 7998404 51.95 µM 1.38713521034035 0.240870294088028 no 915 0.0827002685631686 452 837851
SGTC_386 1509-0011 3.07 µM 1.38369872324163 0.241483904252853 no 916 0.0832253623402287 602 3107280
SGTC_2713 st079149 53.4 µM 1.38290327373758 0.241626058545285 no 917 0.0833472631931592 523 3103253
SGTC_454 lyso-paf C-16 6.67 µM 1.38031440016531 0.242089028941046 no 918 0.0837449315474902 474 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2333 9017922 200 µM 1.38030189842505 0.242091265803981 no 919 0.083746855350629 478 3163164
SGTC_619 1652-1634 108 µM 1.38029095767256 0.242093223377743 no 920 0.0837485389717963 451 5400454
SGTC_2639 lactacystin 53 µM 1.37908692096487 0.242308708043266 no 921 0.0839339779464386 524 3870 A proteasome inhibitor.
SGTC_2962 9082311 13.18 µM 1.37608933641012 0.242845632521458 no 922 0.0843969882796027 461 16459453
SGTC_2054 5233173 129 µM 1.37560025958228 0.242933296546159 no 923 0.0844727131473859 551 6889
SGTC_634 1611-4317 11.2 µM 1.37391100981559 0.243236215862257 no 924 0.0847346555990126 543 2843522
SGTC_1655 st012546 55.1 µM 1.37185450180098 0.243605268013207 no 925 0.0850543682980434 452 720985 YLR208W SEC13
SGTC_1104 tacrolimus 29.8 µM 1.3711149441037 0.243738059769029 no 926 0.0851695635596296 528 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_803 4488-1585 147 µM 1.37045591588312 0.24385642492115 no 927 0.0852723138307576 467 747204
SGTC_1387 3342-1166 1.8 µM 1.36857645245593 0.244194157370987 no 928 0.0855658544161196 406 3418228
SGTC_254 nsc-64875 3.808 µM 1.36757311104815 0.244374557217218 no 929 0.0857228689409312 484 56993
SGTC_2558 carylophyllene oxide 100 µM 1.36672642475733 0.244526846478144 no 930 0.0858555359765994 527 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_690 glyoxal 20.3 µM 1.36212741120477 0.245354940499208 no 931 0.0865788394914408 538 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1154 4088-0362 150 µM 1.36164572038531 0.245441760408423 no 932 0.086654859488193 568 6618304
SGTC_2868 9035608 32.47 µM 1.3589870058761 0.245921263746578 no 933 0.0870753531604378 523 6462614
SGTC_3078 9116413 49.47 µM 1.35882763634463 0.245950022253326 no 934 0.087100606856331 460 17177322
SGTC_943 3253-1379 105 µM 1.35631637275275 0.246403422264177 no 935 0.0874992641533292 502 668464
SGTC_1298 1079-1278 263 µM 1.35623962383037 0.246417286069101 no 936 0.0875114692766549 513 2840950
SGTC_143 4032-1194 15.74 µM 1.35442007138311 0.246746089569985 no 937 0.0878011988337334 608 1806963
SGTC_1509 1326-1131 80 µM 1.35357618468116 0.246898664409615 no 938 0.0879358145633534 456 768313
SGTC_349 k015-0014 24 µM 1.35084887849325 0.247392106864181 no 939 0.0883719234773703 497 2196908
SGTC_755 1995-0008 37.3 µM 1.34990377874091 0.247563223518159 no 940 0.0885234247254329 519 689533
SGTC_890 0929-0006 47.2 µM 1.34647084453433 0.248185310896822 no 941 0.0890753584544419 487 1378169
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.34437166824471 0.248566116267366 no 942 0.0894141153543427 564 688761
SGTC_1192 1488-0095 21.4 µM 1.34370984954145 0.248686239351637 no 943 0.0895211155172563 491 915875
SGTC_108 0509-0257 621.132 µM 1.34306614021906 0.248803105153973 no 944 0.0896252791536803 562 536624
SGTC_2052 5265182 7.135 µM 1.34202662406945 0.248991891633182 no 945 0.0897936816207809 528 1239884
SGTC_1493 4348-0038 111 µM 1.34043050233403 0.249281911535034 no 946 0.0900527123169349 565 800424
SGTC_3085 9117376 49.47 µM 1.33896846564468 0.249547725327946 no 947 0.0902904695013173 515 16480349
SGTC_577 r071-0003 38.6 µM 1.33556063853501 0.250167888603138 no 948 0.0908464614220151 672 4568517 YMR134W ERG29
SGTC_1683 st010134 710 nM 1.33526578725745 0.250221584631358 no 949 0.0908946859769779 523 3818134
SGTC_844 0330-0132 15.3 µM 1.33283222925127 0.250664998639154 no 950 0.0912934333023281 520 2828079
SGTC_1368 1852-0141 284 µM 1.32544665183661 0.252013254812134 no 951 0.0925115262563979 514 2838987
SGTC_2343 7990716 14.84 µM 1.32366968049532 0.252338215639665 no 952 0.0928063860887111 543 6456862
SGTC_1040 k898-0338 155 µM 1.32178106356162 0.252683835475115 no 953 0.0931205329012074 572 20969351
SGTC_614 0462-0418 107 µM 1.32154241593842 0.252727526096205 no 954 0.0931602846834135 482 5188303
SGTC_1905 st060207 84.5 µM 1.31963816560213 0.253076290843713 no 955 0.0934779269834489 528 1948547
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.31904108372771 0.253185698914109 no 956 0.093577688968781 498 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2216 7189485 200 µM 1.31452431337775 0.254014147878072 no 957 0.0943349107967545 515 731273
SGTC_932 2857-0803 154 µM 1.31049437180535 0.254754503352129 no 958 0.0950143234809807 584 674898
SGTC_3280 9140961 49.47 µM 1.31021297359987 0.254806242223377 no 959 0.0950618990257053 509 4901226
SGTC_919 tnp00227 403.569 nM 1.30515352995427 0.255737427184484 no 960 0.0959202870889402 593 1269246 A methoxyflavone. YNL221C POP1
SGTC_286 k060-0067 22.9 µM 1.30433665770391 0.255887938021988 no 961 0.0960594109084854 514 5985051
SGTC_1630 st005209 31.3 µM 1.30187935943214 0.256340980158878 no 962 0.0964788147019149 612 3367314
SGTC_3111 9122088 49.47 µM 1.29966106542181 0.256750316789551 no 963 0.0968585801239011 421 16876704
SGTC_2099 5377090 177.372 µM 1.29700798848113 0.257240329376123 no 964 0.0973142190882441 556 2243829
SGTC_2874 9043904 71.43 µM 1.29273339477807 0.258030850985273 no 965 0.0980516417848794 444 4463428
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.29239460691142 0.25809355853392 no 966 0.0981102617166466 631 65057 A dermal irritant. YDR527W RBA50
SGTC_3136 9095672 49.47 µM 1.29170149302181 0.258221874265869 no 967 0.0982302701150505 477 17217380
SGTC_2629 bisabolol 100 µM 1.2914474539839 0.25826891263075 no 968 0.0982742823255195 581 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1624 st003710 6.25 µM 1.28888670931459 0.25874331300949 no 969 0.0987187376225113 610 24207033
SGTC_1678 st019265 80.2 µM 1.287257560871 0.259045361602322 no 970 0.0990022651896803 593 5367020
SGTC_1049 3226-0134 66 µM 1.28679636242337 0.259130902164044 no 971 0.0990826375785401 587 5702385
SGTC_1753 st043925 64 µM 1.2847916609192 0.259502892842604 no 972 0.0994325486038941 570 670181
SGTC_3290 9121031 71.43 µM 1.28247943286214 0.259932290107398 no 973 0.0998372576353231 489 17014854
SGTC_2719 novobiocin 32.65 µM 1.2806261981509 0.260276713413514 no 974 0.100162496744726 465 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_3259 9138485 49.47 µM 1.27931433426217 0.260520665129162 no 975 0.100393193428893 615 17646153
SGTC_2884 9058502 51.95 µM 1.27468375711031 0.261382698687621 no 976 0.101210599127802 580 6471554
SGTC_2231 micatex 6.853 µM 1.27163143489508 0.261951722518523 no 977 0.101752051191582 521 20737 An antifungal of unknown mechanism.
SGTC_1656 st012921 11 µM 1.27115127958696 0.262041292412559 no 978 0.10183741763516 518 6732821
SGTC_3169 9102970 49.47 µM 1.27097312626925 0.262074529764291 no 979 0.101869104632582 549 17027839
SGTC_1305 1181-0477 144 µM 1.26878608562096 0.262482733197858 no 980 0.102258684575378 546 6252086
SGTC_3182 9108849 49.47 µM 1.2679137850602 0.262645635776948 no 981 0.102414370356305 587 17133045
SGTC_1935 st074532 41.6 µM 1.26764062299932 0.262696659566721 no 982 0.102463158981617 663 2829742
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 1.26686337621855 0.262841868799293 no 983 0.102602073056253 543 616764
SGTC_2682 pyrogallin 40.03 µM 1.26513652154513 0.263164635491828 no 984 0.102911196450489 624 822798 An ATP competetive kinase inhibitor.
SGTC_1386 3228-0095 33.8 µM 1.25946466686738 0.264226185694554 no 985 0.103931272349215 548 870181
SGTC_1090 efavirenz 20.7 µM 1.25944658700574 0.264229573023689 no 986 0.103934535671985 570 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_340 k038-0059 454 µM 1.25922177121464 0.26427169494309 no 987 0.103975119982093 581 23733424
SGTC_508 roscovitine 141 µM 1.25794128347485 0.264511674772211 no 988 0.10420649598542 562 160355 A CDKinase inhibitor.
SGTC_1981 st071826 47 µM 1.25084583369888 0.26584345963802 no 989 0.105495364575922 526 11838600
SGTC_2364 9055074 200 µM 1.2495685919377 0.266083552740509 no 990 0.105728591202084 537 6470630
SGTC_2817 7995342 71.43 µM 1.24916199163202 0.266160007610395 no 991 0.105802915305627 503 18879975
SGTC_99 0109-0120 622.8 µM 1.24413782035932 0.267105641889306 no 992 0.106724421827026 533 759414
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.24318508075906 0.267285154783675 no 993 0.10689981956963 573 7104
SGTC_3059 1327-0034 3 µM 1.2430585513682 0.267308999724308 no 994 0.106923129050041 601 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_965 1291-5240 308 µM 1.24279354115418 0.267358945375974 no 995 0.106971961607861 605 2834598
SGTC_1109 tnp00067 928.257 nM 1.24217326855415 0.267475864627746 no 996 0.107086320082454 601 676295
SGTC_2975 9084847 53.72 µM 1.24037409313622 0.267815148809969 no 997 0.107418529352606 603 27211724
SGTC_681 1642-0006 26.6 µM 1.23966477653336 0.267948969595285 no 998 0.107549705276664 549 4446530
SGTC_2105 5350118 200 µM 1.23882941991775 0.268106612454778 no 999 0.107704338113978 582 2133313
SGTC_2642 cholecalciferol 100 µM 1.23555371909175 0.26872523068974 no 1000 0.108312248410256 552 9821465 A vitamin D precursor, similar to steriods.
SGTC_908 3448-7491 47.7 µM 1.23306526968832 0.269195654789598 no 1001 0.108775706844898 684 1203031
SGTC_2133 5320837 200 µM 1.23234905778904 0.269331126202578 no 1002 0.108909360805197 551 2841355
SGTC_3186 9110464 49.47 µM 1.23144737670983 0.269501727691137 no 1003 0.109077793420785 592 17018021
SGTC_1547 harmine 94.2 µM 1.22791146684629 0.270171257471458 no 1004 0.10974010222961 668 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1980 st071811 45.7 µM 1.2255265460282 0.270623315078819 no 1005 0.110188447231196 583 4974850
SGTC_1870 st057514 26.5 µM 1.225352852658 0.270656253108928 no 1006 0.110221151373424 608 5393161
SGTC_2206 7254556 146.969 µM 1.22189471579499 0.271312447109306 no 1007 0.110873722001775 553 4398905
SGTC_2705 st078069 42.8 µM 1.22142748723391 0.271401166184162 no 1008 0.110962102568311 562 1530061
SGTC_779 1360-0071 233 µM 1.22115112762783 0.271453649163527 no 1009 0.111014402267549 648 7566
SGTC_697 0508-1955 564 µM 1.21937092407409 0.271791845703244 no 1010 0.111351720244932 661 6243113
SGTC_2317 5986382 200 µM 1.21643278457171 0.272350480893054 no 1011 0.111910050708078 625 877883
SGTC_802 4112-3352 742 µM 1.21572663894127 0.272484826946606 no 1012 0.112044536429866 664 704594
SGTC_2696 st077691 74.316 µM 1.21450209511521 0.27271787759876 no 1013 0.112278025134277 540 757133
SGTC_606 k015-0008 38.6 µM 1.20770792031978 0.274012713764785 no 1014 0.113579815201418 664 1970475
SGTC_1121 fusaric acid 630.51 nM 1.20657430978245 0.274229053030681 no 1015 0.113798062679449 625 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 1.20521331402697 0.274488898078134 no 1016 0.114060481936631 543 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_714 4296-0578 26.1 µM 1.20141336242473 0.275215037809123 no 1017 0.114795447650786 553 1589775
SGTC_962 1254-0300 21.5 µM 1.20121201178355 0.275253540640319 no 1018 0.114834485561874 614 7340576
SGTC_2758 dehydroepiandrosterone 69.35 µM 1.19964160213205 0.275553929710174 no 1019 0.115139281056261 654 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2911 7942208 15.64 µM 1.19879021117472 0.275716851742194 no 1020 0.115304764891378 576 1243384
SGTC_2909 7941780 10.49 µM 1.19812208283389 0.275844737819256 no 1021 0.115434746528666 639 1243215
SGTC_395 anisomycin 6.25 µM 1.19525355274571 0.276394132528948 no 1022 0.115993990467039 543 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3146 9095609 49.47 µM 1.19175460231902 0.27706499411471 no 1023 0.116678740609495 624 17173999
SGTC_2006 4011487 200 µM 1.18954487052928 0.277489081104433 no 1024 0.117112662516174 661 45595294
SGTC_2812 7970281 58.44 µM 1.18921530758192 0.277552357295601 no 1025 0.11717747617369 628 2233435
SGTC_2003 4023581 200 µM 1.18646921104831 0.278079882683466 no 1026 0.117718526727388 610 16641307
SGTC_2979 9012552 45.46 µM 1.18096409631035 0.279138886511151 no 1027 0.118808493299249 580 17100905
SGTC_941 3237-0776 460 µM 1.179978026138 0.279328780971959 no 1028 0.119004477302595 602 760008
SGTC_1691 st019933 84.6 µM 1.1784014149946 0.279632530397966 no 1029 0.119318306940834 611 6176082
SGTC_6 0844-0013 19.835 µM 1.17822940807865 0.279665678895622 no 1030 0.119352580786549 871 1584900
SGTC_1431 4049-0260 9.09 µM 1.17238221775031 0.280793659337286 no 1031 0.120521817779418 648 3854841
SGTC_1908 st060353 56.5 µM 1.17145635748462 0.280972468420368 no 1032 0.120707695193817 695 4227716
SGTC_685 1278-0033 54.9 µM 1.16941175053415 0.281367533082957 no 1033 0.12111888891461 664 3590572
SGTC_2775 cyproheptadine 69.59 µM 1.16632500837943 0.281964469432679 no 1034 0.121741532854437 657 2913 A selective serotonin reuptake inhibitor.
SGTC_982 1491-0518 27.5 µM 1.16590537047634 0.28204566910161 no 1035 0.121826353701946 598 3091256
SGTC_2603 homopterocarpin 100 µM 1.1585156702869 0.283477413435698 no 1036 0.123326830289005 664 101795 A weak amylase inhibitor.
SGTC_2782 7736369 71.43 µM 1.15653605847298 0.283861551261944 no 1037 0.123730979647882 690 2950836 YOL077C BRX1
SGTC_2647 atorvastatin 60.16 µM 1.15535103680866 0.284091620375942 no 1038 0.123973351973473 643 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.15337942404514 0.284474601790684 no 1039 0.124377341570036 573 4620898
SGTC_70 0141-0289 43.283 µM 1.15030254872405 0.28507277031728 no 1040 0.12500964072056 856 352408
SGTC_2391 6285546 200 µM 1.14963986516157 0.285201679601399 no 1041 0.125146115820397 682 846083
SGTC_2900 5328528 85.29 µM 1.14719764362512 0.285676995236969 no 1042 0.125649972619101 706 795359
SGTC_688 0527-0193 473 µM 1.14584091126683 0.28594121105441 no 1043 0.125930491959994 634 4007154
SGTC_2622 2-methoxyxanthone 59.94 µM 1.14575618160748 0.285957715520859 no 1044 0.125948025226546 721 71034 A hepatoprotective.
SGTC_2191 5911152 200 µM 1.14478690173169 0.286146553486115 no 1045 0.126148721246866 654 2875902
SGTC_3011 9081274 71.4286 µM 1.14403121005708 0.286293820651055 no 1046 0.126305346947376 700 6625322
SGTC_2271 7849410 118.62 µM 1.14130440294982 0.286825512476885 no 1047 0.126871635268296 684 972430
SGTC_581 0958-0271 211 µM 1.14064877648292 0.286953420840825 no 1048 0.127008055341607 734 4591145
SGTC_2522 biochanin a 4.94 µM 1.13836023165606 0.287400112372749 no 1049 0.127485046389081 637 5280373 A possible chelator.
SGTC_179 1273-0063 6.77 µM 1.13519197931237 0.288019052655994 no 1050 0.128147444688479 609 3108139
SGTC_336 4111-0029 111 µM 1.1332369752073 0.288401290036107 no 1051 0.128557375275082 617 3131175
SGTC_856 0433-0016 11.3 µM 1.13219081588665 0.288605930591686 no 1052 0.128777110223992 699 3911780
SGTC_556 4058-0063 51.5 µM 1.12835210870156 0.289357410371008 no 1053 0.129585622422146 733 6615692
SGTC_1444 4112-3581 28 µM 1.12302908297392 0.290400984690392 no 1054 0.130712571455701 693 2877249
SGTC_1889 st059080 5.18 µM 1.11983927974234 0.291027185844848 no 1055 0.131391128653058 744 176925 Isolated from Daphnopsis sellowiana.
SGTC_555 4296-0685 37 µM 1.11973525031271 0.291047618834658 no 1056 0.131413299396213 701 2908540 YHR072W ERG7
SGTC_1560 lithocholic acid 53.1 µM 1.11959029678471 0.291076091068071 no 1057 0.131444196186315 606 9903 A bile acid which acts as a detergent.
SGTC_3098 9119039 49.47 µM 1.11955982170965 0.291082077244837 no 1058 0.131450692575084 681 17161528
SGTC_2974 9094440 9.66 µM 1.11582211377852 0.291816705650032 no 1059 0.132249143025248 711 25236134
SGTC_2976 9009005 19.48 µM 1.11509881702487 0.291958965814181 no 1060 0.132404039196997 694 2993148
SGTC_2354 9060492 162 µM 1.11377390253039 0.292219637673628 no 1061 0.132688097778097 756 6471895
SGTC_1756 st041558 35.5 µM 1.11300036274827 0.292371878712436 no 1062 0.132854136847614 776 3955792
SGTC_2953 9074162 66.49 µM 1.11118120840462 0.292730053337371 no 1063 0.133245179080834 639 16451992
SGTC_3043 9092303 49.47 µM 1.11023675703123 0.2929160873802 no 1064 0.133448508710785 634 25236084
SGTC_737 1950-0117 57.9 µM 1.10986718306651 0.292988899432281 no 1065 0.133528131844528 690 5393513
SGTC_1259 0671-0132 43 µM 1.10876143594287 0.293206799644883 no 1066 0.133766555433035 683 X1259
SGTC_2819 7996655 46.38 µM 1.10752817497663 0.293449916520389 no 1067 0.134032818863424 608 6456960
SGTC_616 4092-0450 108 µM 1.10730383720847 0.293494151014093 no 1068 0.134081292940982 736 787165
SGTC_1649 st011737 51.3 µM 1.10656204279878 0.293640438606661 no 1069 0.134241662891024 694 1761035
SGTC_1108 betulinic acid 729.144 nM 1.10651171457787 0.293650364943525 no 1070 0.134252548215532 698 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_128 0906-2981 13.371 µM 1.10285668823359 0.294371668065048 no 1071 0.135044702817218 646 6740226
SGTC_1257 0669-0121 16 µM 1.10262431557171 0.294417553416984 no 1072 0.135095173142439 762 4307855
SGTC_3220 9131269 49.47 µM 1.10169199919124 0.294601685998072 no 1073 0.135297798226261 695 17722206
SGTC_2404 5161160 200 µM 1.09546994853492 0.295831899806428 no 1074 0.136655402064784 742 2831543
SGTC_1521 st012942 49.4 µM 1.0930386119185 0.296313260122722 no 1075 0.137188423550115 764 24207259
SGTC_51 1013-0126 23.419 µM 1.08942009170693 0.297030325376638 no 1076 0.1379843376471 687 1627850
SGTC_3223 9129970 49.47 µM 1.08288827452481 0.298326710297904 no 1077 0.139429008508768 752 17248386
SGTC_2309 7664088 163.95 µM 1.08249515405072 0.298404815943099 no 1078 0.139516283757987 788 704922
SGTC_552 k242-0005 476 µM 1.08196487945334 0.298510186273842 no 1079 0.139634066946022 716 4088318
SGTC_3226 9131256 49.47 µM 1.08108546703992 0.29868497073054 no 1080 0.139829548709671 618 17178073
SGTC_450 aminopyrene 156 nM 1.08062645799642 0.298776217901627 no 1081 0.139931654207876 740 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1087 pterostilbene 9.05 µM 1.08021713838048 0.298857597913407 no 1082 0.140022749137448 753 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1779 st039427 55 µM 1.07770342547135 0.29935758938721 no 1083 0.140583064655866 809 1124498
SGTC_1913 st060213 96.1 µM 1.07364139521848 0.300166350585404 no 1084 0.141491718486702 765 688959
SGTC_100 0086-0128 49.5915 µM 1.07269168552266 0.300355582765916 no 1085 0.141704736049201 767 93297
SGTC_2895 9054447 58.44 µM 1.07190417745702 0.300512536711797 no 1086 0.14188153684591 705 2697450
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.07087630627595 0.30071745182703 no 1087 0.142112525380628 734 5377381
SGTC_3055 9094636 49.47 µM 1.06969178732446 0.300953674217487 no 1088 0.142379032118986 695 25236176
SGTC_418 lividomycin a 100 µM 1.06744959365241 0.301401052037601 no 1089 0.142884431929349 784 72394 An antibiotic.
SGTC_2860 9025725 38.96 µM 1.06720529505188 0.301449814246134 no 1090 0.14293957101263 687 40546248
SGTC_712 r015-0009 80.6 µM 1.06572877149891 0.301744605150925 no 1091 0.143273133816705 680 6813872 YLR060W FRS1
SGTC_2876 9059903 25.97 µM 1.0656674233118 0.301756856244053 no 1092 0.143287004408075 790 6916095
SGTC_988 1497-1057 103 µM 1.0648850903472 0.301913105957392 no 1093 0.143463966431816 767 3533044
SGTC_3015 9080845 49.47 µM 1.06211908071736 0.302465832306401 no 1094 0.14409081447715 785 5296973
SGTC_365 0121-0052 13.6 µM 1.06136489579081 0.302616618303571 no 1095 0.144262051902121 809 3101739
SGTC_1033 k072-0102 21.3 µM 1.05990307847681 0.302908978815016 no 1096 0.144594347499676 763 5965931
SGTC_1422 4031-0024 15.5 µM 1.05179998422658 0.304531868837946 no 1097 0.146445663148257 752 782427
SGTC_1494 4358-1428 177 µM 1.05179919995397 0.304532026099381 no 1098 0.146445843097882 788 1564571
SGTC_223 busulfan 5 mM 1.04600687134506 0.30569448113975 no 1099 0.147778929965672 672 2478 A DNA alkylator.
SGTC_1611 st001856 99.4 µM 1.04535090781397 0.305826249442398 no 1100 0.147930408585684 735 647478
SGTC_1485 3909-9022 254 µM 1.0407897351807 0.306743180759409 no 1101 0.148986572549678 778 714516
SGTC_3093 9117344 49.47 µM 1.04005005550794 0.3068919925995 no 1102 0.149158322889073 726 24824913
SGTC_497 capsazepine 133 µM 1.0356372840155 0.307780432963872 no 1103 0.150185695557804 745 2733484 A calcium channel blocker.
SGTC_758 0868-0029 16 µM 1.03512123129733 0.307884405637544 no 1104 0.150306149239076 787 762687
SGTC_3190 9110366 49.47 µM 1.03490699147412 0.307927574533148 no 1105 0.150356174616157 659 17123768
SGTC_2044 5102272 200 µM 1.03158113924561 0.308598067742068 no 1106 0.151134189829352 709 592666
SGTC_1975 st070967 30.8 µM 1.030843508332 0.308746861058317 no 1107 0.151307105776588 843 261391
SGTC_774 k060-0086 136 µM 1.02865237774556 0.309189036299023 no 1108 0.151821527809825 860 5911235
SGTC_3301 9125354 19.7965 µM 1.02778897726928 0.30936334850961 no 1109 0.152024551205596 704 41905162
SGTC_2495 cafestol 54.53 µM 1.02160651702943 0.310612779266711 no 1110 0.153483585973541 717 16667697 An anti-infammatory.
SGTC_2355 9061122 103.12 µM 1.01888433756861 0.311163606765681 no 1111 0.154128940116046 781 5302957
SGTC_1034 k072-0165 12.7 µM 1.01884219545273 0.311172137466918 no 1112 0.154138944945349 819 5835461
SGTC_2116 5511452 16.8835 µM 1.01803387536968 0.311335782886931 no 1113 0.154330928856856 797 870744
SGTC_2777 climbazole 1.536 µM 1.01141066702425 0.312678061950157 no 1114 0.155909958919368 820 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1513 0337-0559 19 µM 1.00961698552898 0.313042003678801 no 1115 0.156339414305072 716 775073
SGTC_392 N-ethylmaleimide 8.33 µM 1.00775411457899 0.313420177021347 no 1116 0.156786259537319 759 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2528 xanthyletin 44.79 µM 1.00760096114014 0.313451276771081 no 1117 0.156823033672282 794 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1488 4013-0813 75.9 µM 1.00497845247598 0.313984016091759 no 1118 0.157453612787366 757 2910057
SGTC_3214 9129694 49.47 µM 1.00497374709098 0.313984972297845 no 1119 0.157454745687213 760 17158655
SGTC_590 k048-0076 22.4 µM 1.00394784698074 0.314193480679133 no 1120 0.157701876149197 786 6832814
SGTC_1502 4534-4282 27.7 µM 0.998531989243145 0.315295204868262 no 1121 0.159010730287982 762 3278949
SGTC_900 1112-0045 141 µM 0.997075719842012 0.31559172832729 no 1122 0.159363878714481 674 56211 YIL048W NEO1
SGTC_3230 9131665 49.47 µM 0.996544867908803 0.315699849174568 no 1123 0.159492739059723 694 15943720
SGTC_2211 7117706 200 µM 0.994274329695776 0.316162477185588 no 1124 0.160044664801111 772 822771
SGTC_1292 0kpi-0043 232 µM 0.992029848916469 0.316620078980483 no 1125 0.160591482472636 768 3333905
SGTC_1075 aripiprazole 15.2 µM 0.990754208623319 0.316880280048523 no 1126 0.160902807014339 858 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1396 3511-0007 98.6 µM 0.988785544817486 0.317282019634295 no 1127 0.161384039061126 723 X1396
SGTC_917 harmaline 728.087 nM 0.986842498735104 0.317678742702156 no 1128 0.161859928405975 813 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2425 5628681 7.85 µM 0.985860274802292 0.317879368824691 no 1129 0.162100841498484 914 5714958
SGTC_665 3914-0008 307 µM 0.98418186577638 0.318222319362391 no 1130 0.162513050218959 791 1069549
SGTC_2267 7931562 200 µM 0.982624026793979 0.318540773238568 no 1131 0.162896257351209 731 934880
SGTC_3139 9095020 49.47 µM 0.982257412452585 0.318615736144239 no 1132 0.16298652481088 654 25236292
SGTC_2250 alverine citrate 130 µM 0.98180534023622 0.318708183139787 no 1133 0.163097878396242 866 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1440 4100-1550 40 µM 0.980845039361526 0.318904598341442 no 1134 0.163334581954174 826 742806
SGTC_2998 9066762 71.4286 µM 0.97989264256689 0.319099447127463 no 1135 0.163569557554934 840 4945196
SGTC_3095 9117207 49.47 µM 0.976506943465213 0.319792524374804 no 1136 0.164406654360839 770 17015229
SGTC_489 paxilline 115 µM 0.974989218690134 0.320103418229605 no 1137 0.164782803961087 763 105008 A toxic potassium channel blocker.
SGTC_1170 0310-0127 64.8 µM 0.973784799222778 0.320350223921199 no 1138 0.165081701071588 854 774975
SGTC_2018 5133068 143 µM 0.973410248403466 0.320426991855397 no 1139 0.165174723710264 783 785362
SGTC_1744 st037937 38.9 µM 0.97298173598603 0.32051482918305 no 1140 0.16528118973985 807 1016152
SGTC_963 1269-2853 151 µM 0.962365384829663 0.322694189502315 no 1141 0.167933047624321 804 3668223
SGTC_76 0433-0009 400.328 µM 0.961822008729894 0.32280590042349 no 1142 0.168069510286282 746 2841569
SGTC_1955 wogonin 32.4 µM 0.960371904771875 0.323104100831 no 1143 0.168434036442484 825 5281703 A flavanone.
SGTC_644 1498-1197 63.3 µM 0.959922740528703 0.323196490361955 no 1144 0.168547050096579 873 6741615
SGTC_1590 st077108 57.8 µM 0.959203610590076 0.323344432408275 no 1145 0.16872809096241 842 5489485
SGTC_409 arachidonic acid 100 µM 0.955783356250712 0.324048441744708 no 1146 0.169590849395307 839 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2497 7-hydroxyflavone 100 µM 0.948488148560312 0.32555215523031 no 1147 0.171440501677586 783 5281894
SGTC_172 1112-0046 2.638 µM 0.947313111447175 0.325794624479316 no 1148 0.171739625817387 768 2802135 YIL048W NEO1
SGTC_641 4092-0595 30 µM 0.944741740532656 0.326325484632309 no 1149 0.172395370793829 889 786260
SGTC_2376 9072922 81.32 µM 0.938488918903978 0.327617848312904 no 1150 0.173996604486417 880 17087968
SGTC_930 2810-3379 265 µM 0.936965938311007 0.327932939154233 no 1151 0.17438803957511 942 1015764
SGTC_3257 9139206 32.98 µM 0.935607669972117 0.328214055898016 no 1152 0.174737612031531 844 4910041
SGTC_1352 1496-0991 99 µM 0.934997928312279 0.328340283967285 no 1153 0.174894683538619 864 3000039
SGTC_2240 6690706 185.951 µM 0.933910511146749 0.328565448548702 no 1154 0.175175028179507 749 805876
SGTC_2641 levomentholum 100 µM 0.932238839325365 0.328911712451997 no 1155 0.1756065537517 846 16666
SGTC_209 4077-0173 175.592 µM 0.930224706936411 0.329329107464487 no 1156 0.176127376069116 779 15993494
SGTC_511 blebbistatin 171 µM 0.926493409193383 0.330102918017708 no 1157 0.177094810343186 879 3476986 A myosin inhibitor.
SGTC_2545 solidagenone 89.61 µM 0.924274028198746 0.330563526816113 no 1158 0.177671830689794 660 6708572 An anti ulcer agent
SGTC_2595 hexamethylquercetagetin 100 µM 0.922771075013891 0.33087559453909 no 1159 0.178063258749401 822 386331
SGTC_2837 9008476 45.46 µM 0.920660556869271 0.331314013257844 no 1160 0.178613837599049 885 2992805
SGTC_3042 9091578 49.47 µM 0.91789400048258 0.331889061306646 no 1161 0.179337181454113 879 25236497
SGTC_109 0132-0036 33.701 µM 0.917525819972837 0.331965620099843 no 1162 0.179433584621689 767 67274 A color developer.
SGTC_460 trequinsin 123 µM 0.91633705042519 0.33221285858599 no 1163 0.179745070463823 948 5537 A vasodilator.
SGTC_3088 9117578 49.47 µM 0.915362638753347 0.332415569729313 no 1164 0.180000642641839 903 678341
SGTC_414 piperonyl butoxide 100 µM 0.911699867169946 0.333177990311588 no 1165 0.180963366965235 873 5794 A potent inhibitor of cytochrome P450.
SGTC_25 0118-0223 35.662 µM 0.910245367797287 0.333480941750914 no 1166 0.181346561561166 897 5333628
SGTC_2540 epiandrosterone 100 µM 0.90995179781583 0.333542101366189 no 1167 0.181423965510129 1072 441302 A steroid.
SGTC_3163 9099914 49.47 µM 0.908275571811839 0.333891395273612 no 1168 0.181866322718633 889 16268368
SGTC_2780 5215298 71.43 µM 0.905677062561501 0.334433160136572 no 1169 0.182553403307782 943 2834131
SGTC_440 fluspirilene 35.1 µM 0.903162553855344 0.334957740160604 no 1170 0.183219814270975 899 3396 An atypical antipsychotic.
SGTC_591 4299-0174 154 µM 0.902152351341098 0.335168580673432 no 1171 0.18348797118773 913 5509088
SGTC_1698 5-fluorocytosine 1.055 µM 0.901574398182955 0.335289229296927 no 1172 0.183641498044584 929 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2724 maprotiline 69.64 µM 0.9007785852165 0.33545538429936 no 1173 0.183853027893618 928 4011 A tricyclic antidepressant.
SGTC_1294 1000-1494 117 µM 0.900513008195156 0.33551084036016 no 1174 0.183923652946519 877 712797 YDL207W GLE1
SGTC_2247 cerulenin 830 nM 0.899754021633296 0.335669346733565 no 1175 0.184125583806621 911 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1994 st072947 40.9 µM 0.897830432801031 0.33607119898683 no 1176 0.184637978701623 905 5286565 YDL195W SEC31
SGTC_2608 thymoquinone 42.66 µM 0.896588958411653 0.336330651926499 no 1177 0.184969146043196 863 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1366 1683-0113 21.9 µM 0.895667833345878 0.336523206174155 no 1178 0.185215097510572 911 708623
SGTC_2274 7947094 46.08 µM 0.894688187218067 0.336728040858775 no 1179 0.185476897558406 993 2971028
SGTC_1628 st004252 77.7 µM 0.894618968333587 0.33674251570206 no 1180 0.185495404255602 931 692968
SGTC_1710 st031758 61.5 µM 0.891114838609983 0.337475604306013 no 1181 0.186433782564731 911 5394341
SGTC_1720 st037298 9.481 µM 0.887829372220995 0.338163507833567 no 1182 0.187316270357267 875 597396
SGTC_669 0108-0021 26.2 µM 0.887327504375023 0.338268635445714 no 1183 0.187451300840206 1020 17201
SGTC_422 cantharidin 155 µM 0.885980400797008 0.338550879196865 no 1184 0.187814044315057 892 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_689 0833-0039 98 µM 0.884795447223763 0.338799224441934 no 1185 0.188133482710678 955 5374726
SGTC_1640 st009078 66.4 µM 0.884552775774349 0.338850092722568 no 1186 0.188198943137731 882 690618
SGTC_363 0455-0021 3.06 µM 0.879471200008527 0.339915955867249 no 1187 0.189572920967459 920 4597466
SGTC_1337 1486-1011 40.3 µM 0.877675184929176 0.340292977784818 no 1188 0.190060007432581 984 X1337
SGTC_3256 9138902 49.47 µM 0.872837475097668 0.341309309956159 no 1189 0.191375835071036 983 17228773
SGTC_1712 st032288 53.4 µM 0.872559212606249 0.341367803949426 no 1190 0.191451690186721 1017 2883011
SGTC_1211 1056-0033 32.3 µM 0.872414141930317 0.341398300994452 no 1191 0.191491244154389 967 6741922
SGTC_3345 9148410 3.559 µM 0.871780819642257 0.341531451389006 no 1192 0.1916639800635 935 4903596
SGTC_1507 4075-3230 155 µM 0.86905618920853 0.342104505551474 no 1193 0.192408199016089 894 659771
SGTC_654 1124-0271 80.9 µM 0.868587380505738 0.342203143825523 no 1194 0.192536429669195 960 5403748
SGTC_3006 9075424 71.4286 µM 0.868398319173336 0.342242925749185 no 1195 0.192588157348628 907 7465181
SGTC_1713 st033146 12.748 µM 0.867033968983517 0.342530061585944 no 1196 0.192961698933657 941 674619
SGTC_1961 st076550 68.7 µM 0.864591339167124 0.343044355237998 no 1197 0.193631563907209 888 1579337
SGTC_2871 9038510 12.99 µM 0.859528817741267 0.34411119024887 no 1198 0.195024413990823 1010 4945164
SGTC_1011 4112-3381 17.4 µM 0.858782629465424 0.344268541179995 no 1199 0.195230226402474 933 2877139
SGTC_3107 9121808 49.47 µM 0.856641815571282 0.344720130506856 no 1200 0.195821434252735 947 662681
SGTC_1302 1159-0335 255 µM 0.855833845163163 0.344890623635201 no 1201 0.196044845734911 933 649284
SGTC_1243 0416-0003 5.65 µM 0.85220203559963 0.345657375158122 no 1202 0.197050983517595 945 2141977
SGTC_1901 st060216 58.6 µM 0.852048826678782 0.345689734738757 no 1203 0.197093496312067 1022 688792
SGTC_2367 9070478 135.38 µM 0.845051746725943 0.347168801042698 no 1204 0.199040973944801 950 572802
SGTC_3181 9108277 49.47 µM 0.844010872194857 0.34738902430945 no 1205 0.199331665111728 974 17097298
SGTC_1144 3486-0183 12.5 µM 0.842085078088463 0.347796610453275 no 1206 0.199870166547243 999 6744069
SGTC_2736 butenafine 14.65 µM 0.837547999434235 0.348757558788972 no 1207 0.201142304155094 998 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3010 9080089 71.4286 µM 0.836100887973242 0.34906425997938 no 1208 0.201549074441214 988 17027233
SGTC_3141 9094609 49.47 µM 0.835130994437377 0.349269874687953 no 1209 0.201821978626247 911 25236309 YDL196W YDL196W
SGTC_2511 berberine 10.47 µM 0.831747736228033 0.349987461973915 no 1210 0.202775674876441 962 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1188 1403-0014 4.57 µM 0.829604319925893 0.350442357010475 no 1211 0.203381266768427 1031 9614867
SGTC_3193 9111931 49.47 µM 0.828362116139071 0.350706086904227 no 1212 0.203732727218517 1001 17087244
SGTC_677 0929-0063 136 µM 0.82515268315772 0.351387808319497 no 1213 0.204642456435278 951 1539583
SGTC_3125 9127534 49.47 µM 0.824666160020678 0.351491193379213 no 1214 0.20478057440118 905 1639235
SGTC_250 brefeldin a 552.239 µM 0.824292120767792 0.351570683340308 no 1215 0.204886797255308 903 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1659 st012954 42.1 µM 0.82151218099882 0.35216167292422 no 1216 0.205677294308204 971 24207262
SGTC_707 0865-0008 204 µM 0.821289156089169 0.352209101463006 no 1217 0.205740791482439 1056 723043
SGTC_334 1502-1024 68.5 µM 0.819849828107679 0.352515244608993 no 1218 0.206150860670585 1036 3296216
SGTC_1821 st053465 65.6 µM 0.81955627118896 0.352577695513802 no 1219 0.206234555439054 981 675086
SGTC_83 0170-0301 39.027 µM 0.81896820523313 0.352702811827764 no 1220 0.20640227700618 960 3089716
SGTC_1636 st007707 68.9 µM 0.818239327246179 0.352857909279177 no 1221 0.206610271528428 1029 403051
SGTC_2440 5628896 157.78 µM 0.817794864713576 0.352952498164189 no 1222 0.206737165420242 1006 5522048
SGTC_48 0382-0018 55 µM 0.815877273188609 0.35336069708102 no 1223 0.207285165864449 1029 762596
SGTC_1393 3470-5649 58.2 µM 0.815023824947073 0.35354242543702 no 1224 0.207529336316511 913 4108395
SGTC_1561 5-methoxyflavone 52.9 µM 0.810047995059966 0.354602613629038 no 1225 0.208956295852254 1006 94525
SGTC_271 rotenone 740 µM 0.807211485604301 0.355207486994395 no 1226 0.209772324802532 1091 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3112 9123419 49.47 µM 0.801071526020399 0.356518055267773 no 1227 0.211545119613907 1095 17015854
SGTC_3099 9120367 49.47 µM 0.798414645192093 0.357085690525138 no 1228 0.212314953648466 1051 24824940
SGTC_3275 9138069 49.47 µM 0.797872230194591 0.357201614934335 no 1229 0.212472319974655 1036 17617007
SGTC_2347 9049783 174.81 µM 0.797653619667507 0.357248339892574 no 1230 0.212535762878875 1058 6467988 YPL169C MEX67
SGTC_2803 7707263 71.43 µM 0.796541485916675 0.357486076138361 no 1231 0.212858686213444 999 2199229
SGTC_1724 st037281 8.293 µM 0.794828692847653 0.357852321019291 no 1232 0.213356578983121 1040 574124 YDL195W SEC31
SGTC_2081 5214970 32.255 µM 0.794030107426623 0.358023126527742 no 1233 0.21358895210411 1027 2063512
SGTC_827 3253-0474 693 µM 0.791686692190815 0.358524512062072 no 1234 0.214271691895153 1081 5402065
SGTC_1185 1319-0113 81.3 µM 0.78975036260781 0.358938983686763 no 1235 0.21483678641333 1035 4672763
SGTC_580 1123-0028 41 µM 0.787152464843962 0.359495324971185 no 1236 0.215596310009122 1159 1677248 YPR107C YTH1
SGTC_367 0335-0881 7.1 µM 0.785082140423911 0.359938899531507 no 1237 0.21620270513134 1044 23828853
SGTC_486 niguldipine 82 µM 0.784493887313715 0.360064969355616 no 1238 0.216375183643702 1012 1236 A calcium channel blocker.
SGTC_854 0422-0053 192 µM 0.782663899881178 0.360457255282861 no 1239 0.21691225332694 1094 3596728
SGTC_1881 5652484 16 µM 0.781691650263704 0.360665731722579 no 1240 0.217197904958011 1027 2255129
SGTC_2555 cholic acid 100 µM 0.780048470886104 0.361018167652981 no 1241 0.217681172629822 1044 6708657 Influences liver metabolism.
SGTC_2318 6029776 164 µM 0.779687427980784 0.361095621459316 no 1242 0.217787440316623 1047 818325
SGTC_1177 0983-0204 23.6 µM 0.779177211599642 0.361205086861428 no 1243 0.217937666042848 1096 766818
SGTC_1857 st056007 79.3 µM 0.778444780610232 0.361362247612177 no 1244 0.218153424018896 1059 619834
SGTC_1229 0139-0193 12.2 µM 0.777484080183857 0.361568424551096 no 1245 0.218436611669251 1110 3090752
SGTC_1708 st033234 31.827 µM 0.773833670228295 0.362352209036247 no 1246 0.219514579228049 1126 674664
SGTC_1348 1493-0373 93.8 µM 0.771897669137062 0.362768124981744 no 1247 0.220087518978546 1059 3010129
SGTC_1181 1222-0449 220 µM 0.771352082130449 0.362885364072808 no 1248 0.220249134675957 1094 658318
SGTC_1653 st012112 65 µM 0.760776511674407 0.36516043472562 no 1249 0.223395283015459 1071 720429
SGTC_1648 st011736 69.8 µM 0.759956491543456 0.36533704126373 no 1250 0.223640296129666 1099 2855514
SGTC_2407 paclitaxel 400 µM 0.759827206341974 0.365364887835974 no 1251 0.223678939084746 1084 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_716 1683-5115 658 µM 0.758235492774134 0.365707783081485 no 1252 0.22415500844468 1160 723597
SGTC_1948 st076329 66.6 µM 0.757794733867291 0.365802752652468 no 1253 0.224286937726705 1041 24208413
SGTC_2079 5212404 121 µM 0.756859563220723 0.366004279510603 no 1254 0.224567001760354 1106 758462
SGTC_1407 3909-7909 12.3 µM 0.756245811493964 0.366136561521424 no 1255 0.224750915339418 1121 4411780
SGTC_999 SEC7.066 22.7 µM 0.754622984100443 0.366486406396611 no 1256 0.225237614438903 1134 740511 YDR170C SEC7
SGTC_3174 9107204 49.47 µM 0.752584504321612 0.366926013743716 no 1257 0.22584981607128 1101 3938802
SGTC_760 0568-0725 82.9 µM 0.750151942637817 0.367450835044928 no 1258 0.226581599368244 1139 3916171
SGTC_2767 sibutramine 71.45 µM 0.749863051105464 0.367513179404559 no 1259 0.226668594933186 1128 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_464 bw-b 70c 158 µM 0.748948017655777 0.367710671625675 no 1260 0.226944268585144 1140 5353454
SGTC_2159 5658611 73.75 µM 0.746705237423674 0.368194880098939 no 1261 0.227620753800163 1143 793844
SGTC_204 PMA1.184 62.41 µM 0.741086524422907 0.369408858898359 no 1262 0.229320489847504 1175 2252213 YGL008C PMA1
SGTC_2011 4012611 177 µM 0.740896107787686 0.369450023204517 no 1263 0.229378217822381 1154 2049887
SGTC_740 k014-0057 261 µM 0.739961866668383 0.369652009312713 no 1264 0.22966156657219 1130 4012779
SGTC_2429 5902844 64.44 µM 0.734275153277107 0.370882270174795 no 1265 0.231390528994138 1158 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1841 st054148 70 µM 0.733591514290964 0.371030257507218 no 1266 0.231598867120813 1091 675442
SGTC_2932 9016711 44.54 µM 0.732066175298275 0.371360516374235 no 1267 0.232064088938281 1142 7117328
SGTC_1983 st071813 46.9 µM 0.731620837662757 0.371456956557926 no 1268 0.232200013050274 1101 11838595
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.731162539466632 0.371556211844144 no 1269 0.232339939177009 1192 6728940
SGTC_391 gliotoxin 8.33 µM 0.723350857406145 0.373249324272231 no 1270 0.234732177416542 1166 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2272 7805186 180 µM 0.717551293761055 0.374507914949422 no 1271 0.236516999251189 1147 2956062 YPR165W RHO1
SGTC_2624 nerol 100 µM 0.715857715950428 0.374875699318468 no 1272 0.237039604999708 1127 637566 A natural product oil.
SGTC_357 1325-0123 420 µM 0.714805678070129 0.375104221556522 no 1273 0.237364563059251 1150 1098503
SGTC_3114 9122766 49.47 µM 0.7139917184638 0.375281058846885 no 1274 0.237616150207727 1112 17176985
SGTC_2916 7875993 68.79 µM 0.712958466145023 0.375505576463832 no 1275 0.237935729298562 1145 1299250
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.710014924360626 0.376145415938172 no 1276 0.238847440662997 1128 689007
SGTC_95 0471-0001 561.058 µM 0.700127208420681 0.378297199097596 no 1277 0.241923932661923 1133 4015405
SGTC_1009 4106-0057 9.87 µM 0.6990651967936 0.378528542016972 no 1278 0.24225564368235 1217 2928005
SGTC_746 1095-0025 46.6 µM 0.698782502935055 0.378590129872584 no 1279 0.242343982421319 1193 6749286
SGTC_2294 7971431 200 µM 0.692912981398728 0.379869561929809 no 1280 0.244182081276828 1128 5741572
SGTC_2058 5236698 133 µM 0.690215894431045 0.380457912256527 no 1281 0.245029214687136 1199 766665
SGTC_2560 caryophyllene 100 µM 0.689311755519775 0.380655205705112 no 1282 0.245313550902057 1252 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2307 7538926 6.34 µM 0.686168585933663 0.381341322477516 no 1283 0.246303402440528 1218 96582
SGTC_715 0868-0130 184 µM 0.684465421537803 0.381713259139488 no 1284 0.246840658553644 1254 2876258
SGTC_2883 9059145 45.46 µM 0.679574741173187 0.382781890918003 no 1285 0.248386883846349 1218 16476510
SGTC_3057 9095946 49.47 µM 0.679309053417619 0.382839970322691 no 1286 0.248471030620664 1246 24540043
SGTC_859 0439-0102 54.6 µM 0.678331595442797 0.383053665527253 no 1287 0.248780734999961 1238 610143
SGTC_905 2-aminofluorene 215 µM 0.678181861455631 0.383086404029165 no 1288 0.248828195874243 1255 1539 An established DNA mutagen. YPR165W RHO1
SGTC_886 0866-0150 153 µM 0.676562735881862 0.383440470106465 no 1289 0.249341714502323 1249 271463
SGTC_1514 1189-1591 158 µM 0.67494781270898 0.383793714205229 no 1290 0.249854460953584 1252 767698 YMR146C TIF34
SGTC_2380 9035439 200 µM 0.674637562087595 0.383861588689104 no 1291 0.249953031185262 1295 6462575
SGTC_1054 3429-0080 167 µM 0.672129705312925 0.384410370871844 no 1292 0.25075056350267 1245 1162877
SGTC_220 paclitaxel 373.376 µM 0.671795727010852 0.384483471240813 no 1293 0.250856874692392 1212 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_698 k064-0052 127 µM 0.671280953089182 0.38459615176576 no 1294 0.251020783038579 1281 5088751
SGTC_1749 st037932 54.2 µM 0.671125477772383 0.384630186177183 no 1295 0.251070298826798 1221 594497
SGTC_2645 abamectin 100 µM 0.670827163145945 0.384695491397442 no 1296 0.25116532055434 1220 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1867 st057372 64 µM 0.670122496365376 0.384849765744499 no 1297 0.251389852556617 1238 688837
SGTC_916 4466-0038 42 nM 0.664296413502136 0.386125980127397 no 1298 0.253250308028609 1294 5722064 YGL116W CDC20
SGTC_1848 st056003 16.4 µM 0.663527922044935 0.386294411977993 no 1299 0.253496251376552 1294 146492
SGTC_745 0469-0705 296 µM 0.663295853073229 0.386345279225128 no 1300 0.253570545987535 1327 3486736
SGTC_521 r062-0005 13.8 µM 0.661676575742936 0.386700263287217 no 1301 0.25408925997617 1180 2832033
SGTC_754 3474-0146 171 µM 0.660751648625356 0.386903071854059 no 1302 0.254385797669594 1199 24762078
SGTC_1734 st037168 69.4 µM 0.66074911608276 0.386903627206544 no 1303 0.254386609868273 1241 708907
SGTC_2266 7929956 200 µM 0.659557114439873 0.387165042797716 no 1304 0.254769041383272 1256 2967153
SGTC_719 2810-4230 27.3 µM 0.659181577330563 0.387247411728235 no 1305 0.254889587789057 1230 721079
SGTC_2564 betulinic acid 100 µM 0.656214402783701 0.387898399139274 no 1306 0.255843091563501 1299 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3340 9146634 11.102 µM 0.655679449461835 0.388015799559585 no 1307 0.256015197082162 1259 4907387
SGTC_3325 9138760 55.175 µM 0.655306005521133 0.388097761329994 no 1308 0.256135377489351 1240 43844959
SGTC_2963 9082507 9 µM 0.653520319463718 0.388489744392655 no 1309 0.256710447081601 1272 16459611
SGTC_2674 ligustilide 100 µM 0.653417437290208 0.388512331933057 no 1310 0.256743600143123 1226 5319022 A signalling regulator.
SGTC_2692 st077426 47.7 µM 0.649875411288563 0.389290204877359 no 1311 0.257886351145244 1247 25238571
SGTC_2415 st077333 57.7 µM 0.648239778826728 0.389649560100866 no 1312 0.258414938646437 1332 2766255
SGTC_2339 9000433 200 µM 0.646454875157682 0.390041818495396 no 1313 0.25899240595638 1234 2988954
SGTC_1235 benzylparaben 21.5 µM 0.645255928755257 0.390305367212986 no 1314 0.259380673747127 1263 7180
SGTC_2765 myclobutanil 7.74 µM 0.644257876243645 0.39052479451231 no 1315 0.259704113092914 1297 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_607 4491-0986 66.8 µM 0.638429668472433 0.391806852122231 no 1316 0.261597011597585 1324 698981 YDR232W HEM1
SGTC_333 3486-0131 40.1 µM 0.637054502839038 0.392109525579502 no 1317 0.262044671321793 1352 6744690
SGTC_2024 5144227 134 µM 0.635266094282726 0.392503251305154 no 1318 0.262627441471014 1285 3475211
SGTC_260 nsc-65238 3.989 µM 0.634651751692449 0.392638526845943 no 1319 0.262827783845948 1238 3246252
SGTC_648 0375-0473 33.3 µM 0.633825387802758 0.392820509001328 no 1320 0.263097391397551 1302 1713139
SGTC_1331 1472-0049 76.2 µM 0.633664253750812 0.392855996731744 no 1321 0.26314997907675 1263 24051409
SGTC_301 4119-0100 24.5 µM 0.630711628497131 0.393506432374641 no 1322 0.264114547163227 1295 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_356 1634-0012 32.5 µM 0.625611853428739 0.394630564239257 no 1323 0.265784781033751 1303 735457
SGTC_2956 9076196 2.52 µM 0.62411199401145 0.394961342347105 no 1324 0.266277018797146 1342 16423868
SGTC_2650 prasterone 100 µM 0.621382404501766 0.395563518544182 no 1325 0.267174023185026 1283 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_3333 9141820 12.094 µM 0.621303810215011 0.395580860972587 no 1326 0.267199873604998 1307 1939433
SGTC_106 0092-0003 11.579 µM 0.620761836071056 0.395700457325387 no 1327 0.267378168496084 1305 1072148
SGTC_2737 bleomycin 30.5 nM 0.620291968031917 0.395804150116466 no 1328 0.267532790975691 1333 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1269 0831-0796 3.05 µM 0.616908279396582 0.396551096528914 no 1329 0.26864761274328 1307 927758
SGTC_1973 st070275 50.2 µM 0.614862162191272 0.397002959634588 no 1330 0.269322876446417 1277 17118334
SGTC_1709 st033179 39.1045 µM 0.614069838669801 0.397177972993869 no 1331 0.269584589061511 1298 573381
SGTC_3211 9128781 49.47 µM 0.612822924089562 0.397453441182596 no 1332 0.269996715683931 1323 17194361
SGTC_2703 st077852 53.4 µM 0.60899466822795 0.398299497954231 no 1333 0.271263986489715 1319 6281836
SGTC_1455 4262-0120 131 µM 0.608683299037813 0.39836833262698 no 1334 0.271367189531259 1390 1529587
SGTC_2614 arthonioic acid 13.39 µM 0.608523378141701 0.398403687715702 no 1335 0.271420202774135 1269 6710684
SGTC_3323 9138564 53.9225 µM 0.607328244017019 0.398667932687135 no 1336 0.27181654903673 1335 43912313 YNL103W MET4
SGTC_322 k048-0136 19.3 µM 0.603438447411804 0.399528290461281 no 1337 0.273108525824993 1333 6823282
SGTC_2939 9044578 71.43 µM 0.600243926249615 0.400235230228462 no 1338 0.274171841470987 1303 2653634
SGTC_2748 diazoxide 86.69 µM 0.600135166426594 0.400259304282112 no 1339 0.274208078797736 1336 3019 A potassium channel activatior.
SGTC_1922 5578187 25 µM 0.599048033377575 0.400499962663251 no 1340 0.2745704270136 1421 1350412
SGTC_2436 5633522 8.09 µM 0.599033230932159 0.400503239737925 no 1341 0.274575362390413 1345 5724242
SGTC_2222 6885208 172.143 µM 0.598449204267775 0.400632541460875 no 1342 0.27477012132771 1310 609514
SGTC_800 3448-7362 155 µM 0.594959541016195 0.401405368715624 no 1343 0.27593525792138 1422 15991913
SGTC_1940 st075990 51.1 µM 0.594861678632966 0.401427047075311 no 1344 0.275967967383212 1431 1084979
SGTC_2356 9061756 188.97 µM 0.594546750884942 0.401496811557436 no 1345 0.276073241559935 1344 20104043
SGTC_2704 st078022 71.1 µM 0.594383207199733 0.401533041869661 no 1346 0.276127918787239 1414 54697681
SGTC_1007 4101-0031 70 µM 0.590655699900128 0.402359036415322 no 1347 0.277375568018398 1347 1146276
SGTC_2286 7945697 125 µM 0.590148463013504 0.402471471037589 no 1348 0.277545560171436 1308 1245733
SGTC_1931 st074438 57.1 µM 0.588994521589691 0.402727284859229 no 1349 0.277932474325713 1321 2787313
SGTC_3243 9134147 49.47 µM 0.588855652767553 0.402758073082858 no 1350 0.277979054492683 1394 24282180
SGTC_3341 9147222 25.867 µM 0.586581668254537 0.403262317572838 no 1351 0.278742348721261 1351 1939759
SGTC_1329 1447-1697 50.6 µM 0.585782055556498 0.403439665895044 no 1352 0.279010991985621 1345 2840515
SGTC_346 4513-0042 7.16 µM 0.583452657141966 0.403956422709998 no 1353 0.2797943093351 1363 2827372
SGTC_3292 9120825 59.784 µM 0.583182359043188 0.404016396869972 no 1354 0.279885272734997 1388 24824900
SGTC_3061 glucosamine 200 µM 0.583117728655958 0.404030737494493 no 1355 0.279907024919091 1315 91431 and experimental redox chemotherapeutic
SGTC_1147 3809-1045 12.3 µM 0.581825169585251 0.40431756624398 no 1356 0.280342224283156 1309 325925
SGTC_1703 st026983 48.3 µM 0.580607073133333 0.404587918251393 no 1357 0.280752652058341 1410 1104023
SGTC_2685 mycophenolic acid 18.85 µM 0.579626557422356 0.404805573194299 no 1358 0.281083239880613 1364 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_191 3914-0123 66.505 µM 0.579553716333537 0.40482174364026 no 1359 0.281107806272026 1282 3144412
SGTC_821 1114-0266 29.2 µM 0.577062092141492 0.405374972470784 no 1360 0.281948755545598 1359 3123235
SGTC_3209 9113616 49.47 µM 0.57680468798777 0.405432136106732 no 1361 0.282035701162396 1415 16649353
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.575479228549171 0.405726522556223 no 1362 0.28248361731892 1374 3256 An antibiotic and ribosome inhibitor.
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.572373661501589 0.406416482033922 no 1363 0.283534427783952 1362 15053
SGTC_1587 estradiol valerate 56.1 µM 0.57038587483018 0.40685825851863 no 1364 0.284208003902938 1385 13791 A steroid.
SGTC_111 0083-0039 52.457 µM 0.569650130200947 0.407021804482503 no 1365 0.284457510230875 1315 759313
SGTC_256 clotrimazole 625 nM 0.56954615177514 0.407044918772077 no 1366 0.284492779918193 1366 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1376 2910-0861 41.3 µM 0.569472836808943 0.407061216802964 no 1367 0.2845176497551 1428 1112859
SGTC_904 1141-0088 396 µM 0.568066092656257 0.407373969350517 no 1368 0.284995045242162 1296 1378119
SGTC_2289 7946404 165.07 µM 0.567568454877898 0.407484620167531 no 1369 0.285164016003698 1398 1246120 YPR165W RHO1
SGTC_1172 0370-0043 85 µM 0.567466812813708 0.407507221404535 no 1370 0.285198533999352 1428 376585
SGTC_867 0518-0118 155 µM 0.566539992004257 0.407713324455554 no 1371 0.285513377363556 1413 6848158
SGTC_1021 4476-0760 85.3 µM 0.564542837932947 0.408157531094015 no 1372 0.286192377473553 1356 746768
SGTC_170 4197-0004 226 µM 0.561969932235666 0.408729970248754 no 1373 0.287068252626695 1433 218692
SGTC_2869 9037858 32.47 µM 0.561873305137546 0.408751472364776 no 1374 0.287101171387566 1336 27187042
SGTC_3023 9089636 49.47 µM 0.559913012645571 0.409187749138796 no 1375 0.287769386242469 1468 17249241
SGTC_3188 9110789 49.47 µM 0.55698627420225 0.409839324441897 no 1376 0.288768403588395 1438 849217
SGTC_3351 9150312 21.596 µM 0.556021379132769 0.41005419223369 no 1377 0.289098119874173 1395 4904905
SGTC_3201 9113999 49.47 µM 0.553497368065393 0.410616379562612 no 1378 0.289961441159108 1483 16649224
SGTC_331 k048-0133 24.5 µM 0.549023774722558 0.411613259066918 no 1379 0.29149456708975 1388 6813582
SGTC_857 0438-0306 1.35 µM 0.548882750137402 0.411644693794279 no 1380 0.291542958429263 1433 4686136
SGTC_533 1222-0222 6.71 µM 0.548868261482675 0.41164792338323 no 1381 0.291547930295236 1506 3982874
SGTC_1056 3448-1962 115 µM 0.548627693497025 0.411701547987815 no 1382 0.291630488373773 1437 715507
SGTC_1349 flufenamic acid 69 µM 0.547903874366996 0.411862903233558 no 1383 0.291878954197892 1380 3371 A non-steroidal anti-inflammatory.
SGTC_2684 capsaicin 100 µM 0.547840346705326 0.411877065662079 no 1384 0.291900766082131 1397 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_50 0929-0078 56.389 µM 0.544938678392457 0.412524066107574 no 1385 0.292897846674793 1464 1377751
SGTC_456 gingerol 170 µM 0.542237071236887 0.41312667163913 no 1386 0.293827600160085 1468 442793 A herb.
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.54169010921142 0.413248698926786 no 1387 0.29401600227131 1383 4174840
SGTC_499 genistein 192 µM 0.536928695713563 0.414311323600855 no 1388 0.295658434252262 1476 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1443 4112-3303 14 µM 0.536588656664887 0.414387235644882 no 1389 0.295775890626928 1410 704433
SGTC_3172 9105863 49.47 µM 0.534092594665636 0.414944566922806 no 1390 0.296638736479893 1441 2348785
SGTC_3073 9114972 49.47 µM 0.532830324448268 0.415226477215992 no 1391 0.297075520130335 1478 41905075
SGTC_2489 cantharidin 73.42 µM 0.532573523882229 0.415283835357445 no 1392 0.297164416879172 1401 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1297 1068-0111 14.1 µM 0.530812993632604 0.415677110238872 no 1393 0.29777418748737 1380 767057
SGTC_1404 3909-7820 48.3 µM 0.530802751259073 0.415679398472216 no 1394 0.297777736666519 1466 23741373
SGTC_35 0133-0054 64.071 µM 0.525475359951496 0.416869968724492 no 1395 0.299626388926921 1354 99677
SGTC_1784 st039334 36.3 µM 0.523603438000644 0.417288489219479 no 1396 0.300277194887188 1525 3496984
SGTC_1837 st055472 66.5 µM 0.523136133296889 0.417392982891256 no 1397 0.300439761039388 1509 676091
SGTC_230 MPP+ 141.667 µM 0.519631112108913 0.418176923677231 no 1398 0.301660354542718 1400 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_123 0083-0120 66.675 µM 0.518736252003427 0.418377122297988 no 1399 0.301972338882612 1383 16001701
SGTC_1051 3253-3903 78 µM 0.51644665254853 0.418889448965707 no 1400 0.302771244666978 1423 5509239
SGTC_2982 9019404 25.97 µM 0.514151909500577 0.419403064633132 no 1401 0.303572893610443 1298 22333232
SGTC_1971 st069429 63.5 µM 0.513148527765348 0.419627687490252 no 1402 0.30392371403141 1473 1246522 YGL099W LSG1
SGTC_3035 9091303 49.47 µM 0.51151421859628 0.419993609463514 no 1403 0.304495517378928 1470 25237002
SGTC_2421 5690543 90.72 µM 0.508360031709476 0.420700027518056 no 1404 0.305600438517853 1502 3397993
SGTC_224 benfluorex 43.875 µM 0.507334697148429 0.420929718639092 no 1405 0.305959998567883 1547 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1434 4073-0095 163 µM 0.504289796926851 0.421611982706532 no 1406 0.307028873144472 1476 24133745
SGTC_753 1322-0200 289 µM 0.502583577166087 0.421994394637396 no 1407 0.307628539042469 1469 5403907
SGTC_2492 derrusnin 100 µM 0.501389547099278 0.422262054197947 no 1408 0.308048497435978 1420 1715307 Part of coumarin class of compounds.
SGTC_2197 6588183 93.1375 µM 0.499478485406391 0.42269052171189 no 1409 0.308721169864014 1457 884136
SGTC_2881 9058953 51.95 µM 0.497754036800956 0.423077228375001 no 1410 0.309328707979702 1417 17122249
SGTC_2256 7954252 200 µM 0.496268603833235 0.423410395351923 no 1411 0.309852457125763 1454 2972920
SGTC_405 ebelactone b 50 µM 0.494433523849874 0.423822060073657 no 1412 0.310500021604637 1476 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_987 1497-1013 404 µM 0.494201604609957 0.423874092599527 no 1413 0.310581903322859 1493 1676435
SGTC_482 fipronil 114 µM 0.491745223066924 0.424425278395578 no 1414 0.311449732167573 1514 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1692 fluoroquinolonic acid 71 µM 0.490869731561276 0.424621765133342 no 1415 0.311759293232128 1518 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2898 9056270 58.44 µM 0.490008793133983 0.424815003988722 no 1416 0.312063838304514 1482 19154699
SGTC_1409 3909-8004 61.9 µM 0.488810139840175 0.425084073508059 no 1417 0.312488059309981 1514 2119279
SGTC_2150 5556613 200 µM 0.487718473760621 0.425329157282315 no 1418 0.312874632313541 1523 743190
SGTC_2761 levamisole 97.89 µM 0.486302783386233 0.425647028881584 no 1419 0.313376253042987 1603 26879 An alkaline phosphatase inhibitor.
SGTC_2292 7671323 168.05 µM 0.482814519422967 0.426430470984598 no 1420 0.314613720250633 1496 937504
SGTC_993 3909-8757 62.7 µM 0.481423890586768 0.426742878589986 no 1421 0.315107630226254 1520 4288324 YLR208W SEC13
SGTC_1477 0139-0234 16 µM 0.480666919951422 0.426912952918935 no 1422 0.315376622745397 1543 620880
SGTC_2587 piperic acid 92.2 µM 0.480595400560861 0.426929022425418 no 1423 0.315402042507832 1478 5370536
SGTC_3305 9127027 53.8275 µM 0.471452648246354 0.428984273311011 no 1424 0.318658763328285 1527 41905295
SGTC_2208 7283366 200 µM 0.471019190909137 0.429081760913855 no 1425 0.318813515228603 1606 898663
SGTC_1851 st056236 18.9 µM 0.470337192853953 0.429235155827559 no 1426 0.319057064502216 1601 5393171
SGTC_1906 st060206 94.7 µM 0.469454655223994 0.429433671935572 no 1427 0.319372344706198 1603 5133468
SGTC_139 0099-0334 718.624 µM 0.469049745997002 0.429524757317758 no 1428 0.319517039341552 1536 97690
SGTC_1540 guanosine 70.6 µM 0.468290992030359 0.429695451092133 no 1429 0.319788254666097 1532 6802 Guanosine is a purine nucleoside
SGTC_3203 9113543 49.47 µM 0.467599763956796 0.429850965284562 no 1430 0.320035416876956 1577 17018012
SGTC_3276 9139060 49.47 µM 0.467341033435074 0.429909177914666 no 1431 0.320127951626172 1558 4870619
SGTC_2315 7733312 200 µM 0.461683904996064 0.431182372564257 no 1432 0.322154007379914 1503 726316
SGTC_1158 4092-0494 91.8 µM 0.461372888359794 0.43125239090938 no 1433 0.322265549651535 1615 1148199
SGTC_3322 9139058 2.11 µM 0.46097171155225 0.431342709963623 no 1434 0.322409450392507 1588 4908926 YPR165W RHO1
SGTC_3039 9090270 49.47 µM 0.460857856030146 0.431368343513068 no 1435 0.32245029482588 1603 17173750
SGTC_2813 7971799 71.43 µM 0.460568969647917 0.431433384987445 no 1436 0.322553939298427 1577 2234054
SGTC_2679 rapamycin 1 nM 0.4600934154639 0.431540457929363 no 1437 0.322724585067683 1543 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1385 3091-4834 14.1 µM 0.458229070473222 0.431960271165427 no 1438 0.323393938277696 1591 4072814
SGTC_1987 st072290 61.9 µM 0.457968880376532 0.432018866897255 no 1439 0.323487399501715 1557 54697379
SGTC_1445 4239-0156 97.7 µM 0.45788076737328 0.43203871059689 no 1440 0.323519052535967 1683 4008346
SGTC_531 3788-1495 174 µM 0.456532586203982 0.432342352314557 no 1441 0.324003521860309 1525 2896655
SGTC_2688 kanamycin b 96.69 µM 0.456212042258458 0.432414552144592 no 1442 0.324118753343359 1531 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2145 5634607 200 µM 0.452716228931178 0.433202100732661 no 1443 0.325376545965943 1508 308662
SGTC_2640 pentamidine 10.38 µM 0.452296952134953 0.433296574702184 no 1444 0.325527535672661 1635 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2710 st078562 53.7235 µM 0.449556376044908 0.433914191438325 no 1445 0.326515174645054 1492 17250908
SGTC_345 1362-0200 395 µM 0.449344605634399 0.43396192279325 no 1446 0.326591542458084 1505 1419823
SGTC_630 4356-0227 183 µM 0.447899810674204 0.434287593668667 no 1447 0.327112752519253 1558 779312
SGTC_2447 5741742 33.78 µM 0.445251485241771 0.43488466770584 no 1448 0.328069011842713 1636 1776504
SGTC_81 0411-0046 9.971 µM 0.445240990305669 0.434887034121467 no 1449 0.328072803610047 1495 12925265
SGTC_934 2950-0684 338 µM 0.442130210035776 0.435588560469645 no 1450 0.329197492294497 1677 1121253
SGTC_1126 isoteolin 1.0172 µM 0.440396584972942 0.435979606341998 no 1451 0.329824948941504 1492 133323
SGTC_952 1185-0122 232 µM 0.43945497290399 0.436192027723747 no 1452 0.330165950642276 1516 678600
SGTC_2521 angolensin 13.4 µM 0.438798536510386 0.436340126273469 no 1453 0.33040376042001 1593 821428 A flavenoid.
SGTC_1204 4049-0315 18.3 µM 0.438464695728211 0.43641544748417 no 1454 0.330524728510391 1684 588402
SGTC_2091 4-phenylthiadiazole 200 µM 0.437875372564811 0.436548416296465 no 1455 0.330738314532076 1585 270010
SGTC_3161 9100388 49.47 µM 0.437528444098334 0.436626697018352 no 1456 0.330864076200167 1633 25236368
SGTC_2828 7998861 71.43 µM 0.436896299055605 0.436769340208864 no 1457 0.331093278035004 1687 2988188
SGTC_678 1218-2179 85.9 µM 0.434778714112207 0.437247231914733 no 1458 0.331861528410702 1607 6820081 YOR116C RPO31
SGTC_3154 9100113 49.47 µM 0.430756910593923 0.438155114849889 no 1459 0.333322566740546 1537 25237525
SGTC_451 chloral hydrate 100 µM 0.430433920748897 0.438228040846356 no 1460 0.333440012445399 1611 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_15 0266-0086 27.098 µM 0.429484643572615 0.438442384746074 no 1461 0.333785283499269 1637 1712902 YIL048W NEO1
SGTC_2174 5790901 200 µM 0.42883294544239 0.438589546659829 no 1462 0.334022400639395 1587 786020
SGTC_1182 1222-0449 220 µM 0.425798321406664 0.439274915735455 no 1463 0.335127405096461 1606 658318
SGTC_3018 9082602 49.47 µM 0.424166934783534 0.439643439377721 no 1464 0.33572203659295 1592 17332089
SGTC_2245 6637752 200 µM 0.423477866889625 0.439799112760319 no 1465 0.335973321791371 1727 681890
SGTC_3281 9140613 49.47 µM 0.423296556706891 0.439840075684672 no 1466 0.33603945310603 1486 16013766
SGTC_1909 st060837 51.5 µM 0.422998833377779 0.439907340916485 no 1467 0.33614805611427 1557 678937
SGTC_3221 9128209 49.47 µM 0.418361408541892 0.440955306397066 no 1468 0.33784144887483 1616 16460723
SGTC_1759 st043059 70 µM 0.417435823700891 0.441164519850737 no 1469 0.338179828226693 1548 669426
SGTC_2137 5261020 140 µM 0.415848693739762 0.441523303044082 no 1470 0.338760362361844 1597 763655
SGTC_1458 k015-0034 6.33 µM 0.414617085468611 0.441801750850978 no 1471 0.339211119352087 1529 3598957
SGTC_1214 0358-0031 63.7 µM 0.412366796794713 0.442310580917012 no 1472 0.34003529797819 1790 4301366
SGTC_2917 7979103 53.79 µM 0.411912551423601 0.442413305402701 no 1473 0.340201760372052 1699 2980565
SGTC_691 1548-0686 185 µM 0.41034821542025 0.442767098882562 no 1474 0.34077526386086 1565 46495133
SGTC_2423 st077119 87.2 µM 0.409442038655828 0.44297206259773 no 1475 0.341107647161169 1572 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3089 9117425 49.47 µM 0.408264503866206 0.443238426258347 no 1476 0.341539748132449 1548 9401657
SGTC_2575 plumbagin 510 nM 0.402428764184173 0.444558873071421 no 1477 0.343684252278282 1554 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1003 4049-0218 100 µM 0.396756356781697 0.445842952962182 no 1478 0.34577356850166 1680 295161
SGTC_3079 9117512 49.47 µM 0.392651460230935 0.446772545914664 no 1479 0.347288463045007 1693 7185044
SGTC_2924 9010168 62.78 µM 0.391177137828963 0.447106491948314 no 1480 0.347833153007143 1634 2993929
SGTC_2791 5663188 71.43 µM 0.391131037508541 0.447116934652355 no 1481 0.347850189890569 1729 54690634
SGTC_3092 9117248 49.47 µM 0.39048002674325 0.447264406361869 no 1482 0.348090810906679 1725 17141857
SGTC_647 0140-0236 81 µM 0.389278999398196 0.447536490960091 no 1483 0.348534884806164 1680 990837
SGTC_587 k089-0003 57 µM 0.387392426121513 0.447963931141818 no 1484 0.349232855006743 1696 9659696
SGTC_2968 9090663 33.37 µM 0.38676206377748 0.448106765588908 no 1485 0.349466182229828 1649 25236811
SGTC_118 0083-0097 135.343 µM 0.38424737993661 0.448676637144106 no 1486 0.350397552268912 1660 5207356
SGTC_3356 9151811 4.48 µM 0.384144170656073 0.448700028451641 no 1487 0.350435797430056 1625 1859254 YPR165W RHO1
SGTC_520 3584-0023 682 µM 0.381098698936806 0.449390332792653 no 1488 0.351565006399911 1621 1340790
SGTC_2021 4019055 173 µM 0.379482644868321 0.449756699361205 no 1489 0.352164744807557 1665 44827708 YER133W GLC7
SGTC_2296 7971656 126.45 µM 0.378783659321442 0.449915175747664 no 1490 0.352424261374154 1627 666570
SGTC_1111 tnp00062 510.699 nM 0.377526221694561 0.450200286386766 no 1491 0.352891290736771 1779 676306
SGTC_2324 6149169 200 µM 0.376284059058701 0.450481958822196 no 1492 0.353352864497722 1731 2888231
SGTC_3180 9109287 49.47 µM 0.374409827001209 0.450907006300299 no 1493 0.354049716436943 1672 18891271
SGTC_1627 st003713 25.6 µM 0.373756477557126 0.451055189329888 no 1494 0.354292751195308 1650 16195070 YER133W GLC7
SGTC_3310 9130229 44.1445 µM 0.373364531487686 0.451144087998428 no 1495 0.354438576882984 1744 7761258
SGTC_3264 9137442 49.47 µM 0.372629017203015 0.451310919194637 no 1496 0.354712286598432 1746 17015726
SGTC_2475 5812728 15.03 µM 0.371796507563508 0.451499761495648 no 1497 0.355022182076298 1624 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_3321 9137793 26.8275 µM 0.371627149406952 0.451538179193327 no 1498 0.355085236130773 1665 4904192
SGTC_2892 9047358 58.44 µM 0.371454835844311 0.451577267769759 no 1499 0.355149394591162 1647 6466771
SGTC_3048 9093155 49.47 µM 0.37060748230365 0.4517694930302 no 1500 0.355464954134613 1740 25236002
SGTC_1372 2752-0194 270 µM 0.370271783233941 0.451845650726125 no 1501 0.355589997904457 1622 823334
SGTC_2745 rifampicin 24.3 µM 0.368739953453624 0.452193188666581 no 1502 0.356160782743111 1796 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_3268 9137683 49.47 µM 0.368236039515858 0.452307523497399 no 1503 0.356348619871872 1676 1953228
SGTC_1767 st044992 70.3 µM 0.367991082339171 0.452363104134178 no 1504 0.356439941812656 1605 9600693
SGTC_403 arphamenine a 50 µM 0.367738357187353 0.452420448298248 no 1505 0.356534168342985 1714 5487158 An arginine aminopeptidase inhibitor.
SGTC_3132 9126706 49.47 µM 0.36686648052286 0.452618287577647 no 1506 0.356859307699612 1714 850858
SGTC_1053 3366-3204 134 µM 0.366102059442411 0.452791753575288 no 1507 0.357144460413626 1625 3632071 YPR165W RHO1
SGTC_2854 9024559 71.43 µM 0.364246709538328 0.453212815638654 no 1508 0.357836894991864 1618 3163529
SGTC_3075 9116269 49.47 µM 0.364169456108901 0.453230349048953 no 1509 0.357865736886686 1687 17015205 YNL244C SUI1
SGTC_3147 9097027 49.47 µM 0.361795126857243 0.453769270253216 no 1510 0.358752567011235 1760 25236841
SGTC_2080 5212524 12.4 µM 0.359966359611326 0.454184418818284 no 1511 0.359436145356267 1821 260183
SGTC_1375 2910-0797 186 µM 0.358964063921995 0.454411971289784 no 1512 0.359810986435845 1708 742508
SGTC_3005 9076496 71.4286 µM 0.358616982952416 0.454490773017589 no 1513 0.359940820114585 1740 21368410
SGTC_2984 9022109 38.96 µM 0.358278846264067 0.454567545746395 no 1514 0.36006732351974 1719 6459207
SGTC_3316 9136639 10.545 µM 0.356876744787522 0.454885905962706 no 1515 0.360592039906146 1752 4903665
SGTC_2512 diallyl trisulfide 49.23 µM 0.355967566580164 0.455092358854569 no 1516 0.36093242723879 1692 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_270 tamoxifen 5.46 µM 0.34904855399859 0.456663896560523 no 1517 0.363526429149816 1838 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2390 9097792 176.6 µM 0.346766498873548 0.457182377028365 no 1518 0.364383373635657 1640 4497149
SGTC_2319 6033012 152.6 µM 0.346093614005459 0.457335269700346 no 1519 0.364636181254722 1624 847246
SGTC_2755 lomerizine 42.69 µM 0.345605187226435 0.457446253824537 no 1520 0.364819723548535 1656 3949 A calcium channel blocker.
SGTC_2152 5568786 200 µM 0.345205716084391 0.457537027225804 no 1521 0.364969860896064 1731 5399883
SGTC_2960 9079389 5.97 µM 0.343074225599921 0.458021411534137 no 1522 0.365771310355109 1834 16457355
SGTC_1775 st081588 35.1725 µM 0.342377649856012 0.458179722936675 no 1523 0.366033353050867 1701 1426443 YGL099W LSG1
SGTC_833 3852-0053 558 µM 0.340584740319507 0.458587229571013 no 1524 0.366708109401579 1769 3123681
SGTC_566 0958-0068 16.5 µM 0.335423234877329 0.459760618815237 no 1525 0.368652921616972 1770 6815365
SGTC_1290 0986-0249 10.2 µM 0.334228519619388 0.460032269376648 no 1526 0.369103562335052 1788 53329
SGTC_3016 9080866 49.47 µM 0.333469477243727 0.460204867722013 no 1527 0.36938996291938 1680 17066299
SGTC_1253 0550-0034 176 µM 0.331969005857938 0.460546081348986 no 1528 0.369956331422218 1720 5969915
SGTC_13 0199-0087 65 µM 0.331718663094895 0.46060301320156 no 1529 0.370050853395618 1777 4589825
SGTC_1682 st012968 530 nM 0.331674668844359 0.460613018264418 no 1530 0.370067465125802 1667 24207270
SGTC_1381 2324-0066 62.1 µM 0.329545156014407 0.461097336462505 no 1531 0.370871834316031 1740 10885928
SGTC_1233 0325-0408 14.2 µM 0.328948074738696 0.46123314191413 no 1532 0.371097468048325 1805 12874
SGTC_181 1447-1644 8.07 µM 0.327986074935155 0.461451957169749 no 1533 0.371461095685489 1858 534600
SGTC_484 loperamide 105 µM 0.327737754553183 0.461508441706616 no 1534 0.371554977295655 1747 3955 An opioid-receptor agonist.
SGTC_931 2812-0076 566 µM 0.327501231922049 0.461562243373889 no 1535 0.371644405676757 1704 3450959
SGTC_1248 0469-0687 58.6 µM 0.32532726033001 0.462056788267098 no 1536 0.372466700635495 1802 4017482
SGTC_3130 9127414 49.47 µM 0.324062950476634 0.462344426222444 no 1537 0.372945187918289 1746 1494646
SGTC_1128 3448-9350 235 µM 0.322702550525701 0.462653947233259 no 1538 0.37346026018429 1713 619386
SGTC_1245 0418-0076 17.2 µM 0.320769134594152 0.463093880888555 no 1539 0.374192675688145 1756 6790114
SGTC_595 3909-8003 73.7 µM 0.319062726171125 0.463482198283183 no 1540 0.374839473897941 1780 699517
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.318078571569235 0.463706172440547 no 1541 0.375212668797397 1643 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2723 salbutamol 83.58 µM 0.317158582520994 0.463915554189111 no 1542 0.375561637562781 1835 9884233 β2-adrenoceptor agonist
SGTC_401 neomycin 50 µM 0.316021880118979 0.464174271866711 no 1543 0.375992950306701 1787 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2989 9073649 71.4286 µM 0.314894205260195 0.46443094981165 no 1544 0.376420990746009 1905 21367202
SGTC_3295 9122362 53.5725 µM 0.314560232846818 0.464506970449622 no 1545 0.376547788489532 1711 4730473
SGTC_2029 5175081 200 µM 0.313638282587943 0.464716836556219 no 1546 0.376897890137808 1747 1380876
SGTC_1261 0712-0010 12.7 µM 0.313617626291523 0.464721538719176 no 1547 0.376905735326232 1877 2840123
SGTC_1285 0929-0069 65.5 µM 0.311562774033405 0.465189326185165 no 1548 0.377686414457457 1768 1206237
SGTC_2348 9022543 33.42 µM 0.310626290331591 0.465402532857304 no 1549 0.378042369218926 1791 3162678 YDL140C RPO21
SGTC_1949 st076024 69.1 µM 0.310568117492215 0.465415777236124 no 1550 0.378064483967087 1667 2921930
SGTC_3293 9120939 62.045 µM 0.309994709002093 0.465546328855337 no 1551 0.378282489956478 1813 934087
SGTC_1197 1601-0112 267 µM 0.308894236040572 0.46579689102661 no 1552 0.378700990760772 1716 7350313
SGTC_1466 k213-0079 57.5 µM 0.306042494052611 0.46644625530474 no 1553 0.379786145717039 1763 3657981
SGTC_2929 9013348 24.6 µM 0.30491946401284 0.466702002767811 no 1554 0.380213745558689 1768 2995952
SGTC_2160 5660466 132.927 µM 0.303726524144276 0.466973685842633 no 1555 0.380668124348018 1901 2859134
SGTC_2582 agaric acid 100 µM 0.303426914512019 0.467041922103575 no 1556 0.380782268535612 1717 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_3233 9132340 49.47 µM 0.303009390834293 0.467137014969205 no 1557 0.380941352492236 1721 17682950
SGTC_1328 1441-0025 69.2 µM 0.301440578704538 0.467494335595723 no 1558 0.381539277541026 1672 4562601
SGTC_1391 3442-0225 151 µM 0.296361148563269 0.468651430667493 no 1559 0.383477146128904 1794 5227075
SGTC_2393 9031399 185.94 µM 0.294030734412006 0.469182388641069 no 1560 0.384367209101885 1869 1526623 YDL150W RPC53
SGTC_2694 st077685 81.9 µM 0.293903732415388 0.469211326163987 no 1561 0.384415732975036 1740 2838096
SGTC_473 2-arachidonoylglycerol 10 µM 0.293841906499385 0.469225413315255 no 1562 0.384439355565542 1740 5282280 An endocannabinoid.
SGTC_2992 9074591 71.4286 µM 0.292700349591282 0.469485526108588 no 1563 0.384875601327349 1837 17741321
SGTC_1295 1013-0063 9.78 µM 0.290618317426376 0.46995996710579 no 1564 0.385671624595074 1917 6826038
SGTC_3336 9143619 71.43 µM 0.290532478019952 0.469979528594748 no 1565 0.385704453934787 1901 45595730
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.29042272837358 0.47000453896753 no 1566 0.385746428954692 1822 165521
SGTC_2223 6903751 107.57 µM 0.290269943998726 0.470039356535686 no 1567 0.385804865331189 1860 5598863
SGTC_2155 5570423 76 µM 0.289822785209777 0.470141259512244 no 1568 0.385975907782066 1788 797402
SGTC_162 k030-0015 37.8 µM 0.286118575613953 0.470985486081481 no 1569 0.387393652365872 1935 1809920 YMR134W ERG29
SGTC_312 4092-0653 6.84 µM 0.284167970150716 0.471430101314949 no 1570 0.388140830091076 1890 1148278
SGTC_1037 k284-1091 78.7 µM 0.28390208727753 0.47149070863991 no 1571 0.388242708435605 1761 3334711
SGTC_22 0964-0034 14.468 µM 0.282649934622507 0.471776142507164 no 1572 0.388722599068919 1794 138402
SGTC_573 3702-0553 84.7 µM 0.281819247927146 0.471965509308511 no 1573 0.389041055592052 1803 1222756
SGTC_201 4262-0159 12.803 µM 0.28121435650257 0.472103406868993 no 1574 0.389272996950918 1936 1341029
SGTC_2453 5731132 22.18 µM 0.280307024860651 0.472310258221912 no 1575 0.389620980839966 1943 1362040
SGTC_64 000l-0018 272.079 µM 0.27989003746421 0.472405324544849 no 1576 0.389780935414141 1776 6811119
SGTC_3258 9138477 49.47 µM 0.278430356443405 0.472738120349303 no 1577 0.390341009678065 1844 4970355
SGTC_2179 6298986 200 µM 0.277616465176689 0.472923689442613 no 1578 0.390653395711907 1952 738374
SGTC_1992 st073643 23.3 µM 0.275032389215958 0.473512903500519 no 1579 0.391645677250732 1796 3161292
SGTC_1008 4106-0037 6 µM 0.272564774192355 0.474075616561188 no 1580 0.392593896533168 1834 2905394
SGTC_1465 k213-0056 144 µM 0.27187207524719 0.474233588450732 no 1581 0.39286019174043 1812 24048857 YMR208W ERG12
SGTC_2621 lithochol-11-enic acid 100 µM 0.271035246230941 0.474424434998683 no 1582 0.393181961952205 1971 6708711
SGTC_977 1348-1378 135 µM 0.270468902288806 0.474553598272457 no 1583 0.393399769023483 1842 X977
SGTC_918 glabranin 770.725 nM 0.268761942394082 0.474942912333715 no 1584 0.394056440819454 1868 124049 Also referred to as licorice root.
SGTC_29 0299-0004 12.984 µM 0.265846693762955 0.47560786139411 no 1585 0.395178640150939 1910 16871 A napthoquinone isolated from Swertia calycina.
SGTC_3116 9124943 49.47 µM 0.263835221033418 0.47606670483212 no 1586 0.395953446695055 1740 41905195 YPL160W CDC60
SGTC_321 4534-3890 65.3 µM 0.263410091963113 0.476163686458952 no 1587 0.396117256466592 1951 699746
SGTC_1733 st037357 54.9 µM 0.263291134158349 0.47619082369756 no 1588 0.396163096304757 1710 1272339 YGL099W LSG1
SGTC_953 1188-0045 9.7 µM 0.260926267423211 0.476730331466016 no 1589 0.397074683922991 1880 6144426
SGTC_96 0929-0093 37.281 µM 0.259802670154493 0.47698667781296 no 1590 0.397507995589796 1807 6991579
SGTC_2253 7938677 135.83 µM 0.256865802335712 0.477656762720661 no 1591 0.398641185390243 1981 2301972
SGTC_1657 st012939 43.4 µM 0.255815474238442 0.477896424285229 no 1592 0.399046662340984 1955 24207257
SGTC_2666 tannic acid 100 µM 0.255554291852013 0.477956021554447 no 1593 0.399147508184223 1891 16134267 A thiamine antagonist.
SGTC_560 2332-1943 155 µM 0.25387772926692 0.478338595601791 no 1594 0.399795010344737 1865 21177716
SGTC_2583 asiatic acid 100 µM 0.253842378427463 0.478346662509745 no 1595 0.399808666101074 1876 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1081 sertraline 6 µM 0.253225695417855 0.478487388317115 no 1596 0.400046905686587 1954 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3175 9106517 49.47 µM 0.250064515994462 0.479208804760597 no 1597 0.40126872824019 1851 41468073
SGTC_2014 4013930 200 µM 0.247221998619185 0.479857557197936 no 1598 0.402368210587342 2011 64556
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.247113065537313 0.479882420247803 no 1599 0.402410361204985 1982 1241132 A phosphatase inhibitor.
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.246590487274466 0.48000169538041 no 1600 0.402612583651996 1867 5379071
SGTC_2342 7990637 118.86 µM 0.246269942786649 0.480074858488007 no 1601 0.402736637857544 1882 2033102 YER133W GLC7
SGTC_2180 6301957 200 µM 0.244752008509623 0.480421330512183 no 1602 0.403324227735602 1986 845462
SGTC_3133 9127736 49.47 µM 0.244043576368738 0.480583036872208 no 1603 0.403598535466772 2042 27243420
SGTC_186 3455-3465 67.277 µM 0.242186600975391 0.481006924227646 no 1604 0.404317788463543 1898 755278
SGTC_2239 6685329 187.64 µM 0.241691690058556 0.481119900009591 no 1605 0.404509534536976 1830 805680
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.241387580147021 0.481189321447723 no 1606 0.404627368902063 1978 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2816 7982706 58.44 µM 0.239987511966721 0.481508932781571 no 1607 0.405169968878647 1853 2981853
SGTC_1914 st062367 72.6 µM 0.239515643650826 0.481616654839418 no 1608 0.4053528837761 1848 978205
SGTC_636 0kpi-0074 126 µM 0.236543494297927 0.482295192562468 no 1609 0.40650548054955 1876 616434
SGTC_2864 9034755 47.6 µM 0.236213688030313 0.482370490089638 no 1610 0.406633429256617 2046 4930451
SGTC_60 0986-0278 202 µM 0.235607459414226 0.482508898787471 no 1611 0.406868642312016 1710 3110598
SGTC_2437 5741531 144.16 µM 0.234487194574454 0.482764673175082 no 1612 0.407303386678394 2012 2262990
SGTC_780 0109-0199 192 µM 0.230597925212491 0.483652709990875 no 1613 0.408813589808201 2024 610414
SGTC_1680 diphenhydramine 100 µM 0.228452443621901 0.484142622760348 no 1614 0.409647261528298 1854 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_539 4859-0462 2.54 µM 0.228189326690283 0.484202706199391 no 1615 0.409749529320949 2030 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1650 st011916 45.8 µM 0.226968772988795 0.48448142749699 no 1616 0.410224012033506 2014 242528
SGTC_1057 3448-5381 134 µM 0.225480089521229 0.484821388204094 no 1617 0.410802906424563 2002 5497911
SGTC_889 0919-1524 82.7 µM 0.225056903916651 0.484918030300752 no 1618 0.410967503311675 1876 3905452
SGTC_949 1165-0505 146 µM 0.220905485624303 0.485866127939334 no 1619 0.412583013012072 1852 6244267
SGTC_3234 9132280 49.47 µM 0.220338695580947 0.485995577321468 no 1620 0.4128036929356 1921 17612295
SGTC_899 1083-0020 478 µM 0.21842707710947 0.486432183355103 no 1621 0.41354818517335 2004 767123
SGTC_136 0097-0015 404.482 µM 0.217306193545885 0.486688196287441 no 1622 0.413984865334684 2052 4861337
SGTC_1623 st003709 20.3 µM 0.216789911405088 0.486806118420257 no 1623 0.414186037267227 1855 16192618
SGTC_1447 4239-0816 81.9 µM 0.216287255335837 0.486920929379892 no 1624 0.41438192136668 1853 1341554
SGTC_613 3914-0030 117 µM 0.2156944904648 0.487056323355305 no 1625 0.414612948054859 1966 1145395
SGTC_958 1222-0007 33 µM 0.215662505538795 0.487063629104559 no 1626 0.414625414835886 1977 7312461
SGTC_822 1487-0950 154 µM 0.214857573304534 0.487247486918724 no 1627 0.414939181967464 2040 1958375
SGTC_877 0771-0151 33.1 µM 0.213464850840687 0.48756561064662 no 1628 0.415482201122132 1949 6166523
SGTC_3304 9125678 46.087 µM 0.211899225294511 0.487923238092483 no 1629 0.416092827499066 1903 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1814 st052110 31.539 µM 0.211343689293449 0.488050138550559 no 1630 0.416309546816727 2026 674163
SGTC_2950 9072895 21.46 µM 0.211012938193193 0.488125692224327 no 1631 0.416438587722341 1871 17332245
SGTC_978 1416-0512 87.4 µM 0.210979974279431 0.488133222214471 no 1632 0.41645144892399 1926 6814003
SGTC_2387 9077560 195.08 µM 0.20976920852755 0.488409801935435 no 1633 0.416923903196872 1900 5303272
SGTC_2820 7989630 71.43 µM 0.206538661099971 0.489147794807412 no 1634 0.418185084249885 2077 2984098
SGTC_237 nikkomycin 200 µM 0.205289363562467 0.489433196997331 no 1635 0.418673026869713 2040 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_387 norethindrone acetate 66.7 µM 0.203092655475845 0.489935048285931 no 1636 0.419531306095396 1904 541197
SGTC_1684 st024538 14.6195 µM 0.202334445065484 0.490108269793202 no 1637 0.419827636773179 1903 6732859
SGTC_3008 9078912 71.4286 µM 0.201854602488944 0.490217896073307 no 1638 0.420015196707471 1909 16648731
SGTC_1752 st044819 83.042 µM 0.201215704720111 0.490363861727194 no 1639 0.420264956018146 1909 441209 YML126C ERG13
SGTC_1574 spiramycin 23.7 µM 0.200840934303729 0.490449484178897 no 1640 0.420411477035899 1978 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1674 st016616 23.6 µM 0.199056483805947 0.490857177147162 no 1641 0.421109280434181 1848 625830
SGTC_1719 st032227 49.2 µM 0.198834727317681 0.490907842473688 no 1642 0.421196014928931 1890 3125804
SGTC_3143 9086658 49.47 µM 0.198281124259515 0.491034326354762 no 1643 0.421412559578123 1906 25236626
SGTC_2942 9052777 62.25 µM 0.196174408700809 0.491515664128316 no 1644 0.422236828880326 1953 6469503
SGTC_629 3448-6466 76.7 µM 0.195140678963048 0.491751853005012 no 1645 0.422641408734759 1977 573744
SGTC_2357 9067248 200 µM 0.194229102448574 0.491960134442941 no 1646 0.422998248150317 1964 9150235
SGTC_1213 1315-0166 115 µM 0.194169077589266 0.491973849292431 no 1647 0.423021747285543 1833 768401
SGTC_1607 st000305 50.6 µM 0.194002684963884 0.492011867753687 no 1648 0.423086889774588 2055 5457690
SGTC_249 wiskostatin 11.211 µM 0.192899900580745 0.492263840866799 no 1649 0.423518681448074 2050 2775510 A n-wasp and actin depolymerizer.
SGTC_1822 st052468 42 µM 0.19267293261755 0.492315700732786 no 1650 0.423607561438689 1971 2873678
SGTC_2677 mitomycin C 100 µM 0.192437444545901 0.492369507493983 no 1651 0.423699781987259 1966 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2439 5492030 7.2 µM 0.190745144403618 0.492756185837115 no 1652 0.424362633931423 2081 5722370
SGTC_264 promethazine 12.5 mM 0.189074027372307 0.493138030673719 no 1653 0.425017398734619 2110 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_507 nimesulide 162 µM 0.189031741367031 0.493147692972195 no 1654 0.425033969618246 2069 4495 A COX2 inhibitor.
SGTC_1152 3909-8331 15.9 µM 0.188805094452962 0.49319948157246 no 1655 0.425122789431053 1941 16001939
SGTC_2046 4110841 106 µM 0.187744236782189 0.493441888032005 no 1656 0.42553857544153 2110 44119630 YMR134W ERG29
SGTC_1819 st053448 58.6 µM 0.185486289346301 0.493957837997152 no 1657 0.42642381659611 1988 2857616
SGTC_1950 st077106 7.18 µM 0.184088141592277 0.49427732543922 no 1658 0.42697215456994 1939 13831864
SGTC_69 0096-0274 206.684 µM 0.182807525831169 0.494569959148966 no 1659 0.427474521682088 2049 6741392
SGTC_1282 0886-0010 32.4 µM 0.182323729989065 0.494680512182197 no 1660 0.427664338474596 2091 2836211 YNL267W PIK1
SGTC_1221 2958-7315 257 µM 0.181768216271243 0.494807454095887 no 1661 0.427882314349158 2006 4562705
SGTC_2478 5763493 32.33 µM 0.180652348193416 0.495062445647076 no 1662 0.428320231946847 2017 1365576 YLR208W SEC13
SGTC_2619 obliquin 87.91 µM 0.179975482435688 0.495217119982928 no 1663 0.428585908036216 2039 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2311 7694451 200 µM 0.178212076482548 0.495620088943339 no 1664 0.429278212938667 2015 2163142
SGTC_1552 6-methylflavone 10.6 µM 0.177373923008467 0.495811623196195 no 1665 0.42960734447919 2106 689013
SGTC_1457 k015-0032 57.3 µM 0.174522521123217 0.49646323054992 no 1666 0.430727416528515 1974 4302660
SGTC_2472 5377652 49.4 µM 0.171679122251266 0.497113018438952 no 1667 0.431844900065371 1953 1610903
SGTC_2382 9035899 200 µM 0.170042075554123 0.497487128213442 no 1668 0.432488523476206 1967 6462679
SGTC_1209 2323-2347 50.3 µM 0.169275304481832 0.497662357075461 no 1669 0.432790049911833 2140 5412760
SGTC_2082 5219693 150 µM 0.168762597589129 0.497779525345268 no 1670 0.432991689538127 2040 2834649
SGTC_1286 0929-0070 131 µM 0.166452921900553 0.498307354892104 no 1671 0.433900264566489 2050 1420408
SGTC_1191 1487-1166 10.6 µM 0.166044689143455 0.498400648545781 no 1672 0.43406089071762 2073 3955771
SGTC_2304 7443016 91.4 µM 0.163469504966821 0.498989158592165 no 1673 0.43507439083622 2046 939854
SGTC_946 3434-1334 87.4 µM 0.163353898107284 0.499015578432879 no 1674 0.435119899606791 2076 4047976
SGTC_2549 cedrol 20.94 µM 0.162790732336526 0.499144279765217 no 1675 0.435341602727009 2113 6708665 A sedative which affects the nervous system.
SGTC_1115 galangin 695.678 nM 0.162093070789611 0.499303717792155 no 1676 0.435616281373655 2113 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1583 clindamycin 39.6 µM 0.161415113086775 0.49945865296589 no 1677 0.435883232116008 1936 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1324 1418-0026 34.4 µM 0.159661923038623 0.499859313687636 no 1678 0.436573698526364 2040 1372513
SGTC_495 decylubiquinone 155 µM 0.158430708028035 0.499859313687636 no 1679 0.437058708916794 1973 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_3102 9121669 49.47 µM 0.157870167916897 0.499731212078411 no 1680 0.437279552896187 2017 41905072
SGTC_2957 9076800 11.52 µM 0.15666515452828 0.499455827518141 no 1681 0.437754375280292 1990 16459615
SGTC_2665 lovastatin 100 µM 0.154576238895216 0.498978443377365 no 1682 0.438577701715989 2033 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_3348 9149464 3.537 µM 0.154244938954304 0.49890273084442 no 1683 0.438708304989056 2160 1951442
SGTC_298 1391-0729 10 µM 0.153430370874501 0.498716576404224 no 1684 0.439029447966672 2023 3237558
SGTC_1772 st048439 82.2 µM 0.153064463111106 0.49863295505393 no 1685 0.439173719960648 2001 2927068 YDL195W SEC31
SGTC_3138 9097216 49.47 µM 0.153034820985183 0.49862618090509 no 1686 0.439185407764507 2197 25237486
SGTC_9 0092-0002 10.449 µM 0.15210315625025 0.498413266712754 no 1687 0.439552787423619 2124 759368
SGTC_882 0843-0131 351 µM 0.150666305656912 0.498084902842532 no 1688 0.440119476974122 2155 5425421
SGTC_87 0100-0052 35.5 µM 0.149975966829104 0.497927139963774 no 1689 0.44039178823602 2096 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_950 1165-0508 94.1 µM 0.149863602799194 0.497901461483313 no 1690 0.440436114056529 2004 6148369
SGTC_2244 6635614 200 µM 0.149584642394746 0.497837710876901 no 1691 0.440546162719586 2002 836499
SGTC_1740 st038286 13.222 µM 0.148952651790336 0.497693282757534 no 1692 0.44079549723085 2095 716786
SGTC_1893 st059353 36.1 µM 0.147842578722797 0.497439599720902 no 1693 0.441233502792982 1997 3112488
SGTC_2958 9077254 16.72 µM 0.145497967396195 0.496903793365052 no 1694 0.442158860228575 2044 16457351
SGTC_2368 9071271 200 µM 0.145440698120637 0.496890705870816 no 1695 0.442181466900486 2011 27209959
SGTC_273 hydroxyurea 18.1 mM 0.144926366970242 0.496773168199612 no 1696 0.442384504188388 2051 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2471 5466956 24.79 µM 0.14453725646835 0.496684246797991 no 1697 0.442538119451009 2073 724419
SGTC_1114 scopoletin 1.73284 µM 0.143715375379376 0.496496427129133 no 1698 0.442862614722947 2161 5280460 A coumarin with genotoxic properties.
SGTC_2264 7948757 110.76 µM 0.14286423980308 0.496301922922796 no 1699 0.443198700656785 2004 2971411
SGTC_545 4218-0007 221 µM 0.141644221471653 0.496023122001959 no 1700 0.443680517686864 2074 2840508
SGTC_269 exalamide 29 µM 0.141548643398704 0.496001280398335 no 1701 0.443718267484796 2057 3316 A derivative of salicylamide.
SGTC_2102 5377816 72.7585 µM 0.141048849102573 0.495887067067077 no 1702 0.443915676026041 2156 1379702
SGTC_1606 st000094 49.2 µM 0.138379681136114 0.495277112931702 no 1703 0.444970177310065 2177 1242210
SGTC_3091 9116372 49.47 µM 0.137478622226289 0.495071206764959 no 1704 0.445326244641549 2087 17169793
SGTC_282 k297-0036 65.7 µM 0.135778469689599 0.494682698726594 no 1705 0.445998206057614 2129 5061378
SGTC_1449 4112-4002 201 µM 0.135554487778459 0.494631516173647 no 1706 0.446086743369179 1991 2059539
SGTC_2153 5569715 200 µM 0.13461384055874 0.494416567977327 no 1707 0.446458599016767 2182 2054701
SGTC_110 0850-0284 111.64 µM 0.132675758944521 0.4939737002734 no 1708 0.447224907456092 2179 3906265
SGTC_1412 3909-8563 178 µM 0.132478543419525 0.493928635299398 no 1709 0.447302896650271 2192 23767530
SGTC_2490 carminic acid 95.39 µM 0.132368734440203 0.493903543298234 no 1710 0.447346321669757 2116 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_823 0417-1665 178 µM 0.129257409870148 0.493192597634124 no 1711 0.448576985327131 2085 3429856
SGTC_2283 7944793 200 µM 0.128345880898026 0.492984314914823 no 1712 0.44893762880685 2092 2970533
SGTC_1675 st018485 24.5 µM 0.128296569326009 0.492973047363948 no 1713 0.448957139975996 2041 3323024
SGTC_1757 st041620 31.8375 µM 0.127724945404735 0.492842433370937 no 1714 0.449183324099027 2050 5289815
SGTC_1120 ficusin 1.78878 µM 0.126795510363428 0.492630062479095 no 1715 0.449551124634361 2107 6199 A DNA cross-linker.
SGTC_421 streptovitacin 30 mM 0.12632917787848 0.49252350880577 no 1716 0.449735680333659 2050 91467 include heat shock
SGTC_1187 1391-0724 117 µM 0.125220283294517 0.492270136395749 no 1717 0.450174579941302 2079 6997986
SGTC_1780 st038448 24.544 µM 0.120284510235478 0.491142396034204 no 1718 0.452128887030257 2145 728868 YDL195W SEC31
SGTC_2329 6138490 200 µM 0.119635478615059 0.490994108398886 no 1719 0.452385956841385 2046 720019
SGTC_3021 9087658 49.47 µM 0.11950405142157 0.490964080694224 no 1720 0.452438015234774 2201 25237042
SGTC_2 0422-0095 29 µM 0.117634505028897 0.490536943463569 no 1721 0.453178631844783 2124 6790840
SGTC_1098 clofazimine 15.1 µM 0.11752251081421 0.490511356367181 no 1722 0.453223003298523 2174 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_3167 9103034 49.47 µM 0.116368082342821 0.490247608675776 no 1723 0.453680415053745 2190 5127859
SGTC_831 k061-1017 217 µM 0.115168606355814 0.489973573675847 no 1724 0.454155740783459 2169 1240153
SGTC_359 0081-0058 15.9 µM 0.113933080935717 0.489691307690409 no 1725 0.45464542075386 2184 3494159
SGTC_3145 9085516 49.47 µM 0.11366873281064 0.489630915843863 no 1726 0.454750199718306 2008 25236195
SGTC_2966 9084041 48.03 µM 0.113200970613312 0.489524053468267 no 1727 0.45493561308859 2052 17741380
SGTC_2875 9039966 71.43 µM 0.112587645966674 0.489383937837768 no 1728 0.455178739929849 2173 6463691
SGTC_1289 0976-0073 69.1 µM 0.112577059225656 0.489381519280359 no 1729 0.455182936747116 2142 3391136
SGTC_3229 9132204 49.47 µM 0.111112823346133 0.489047016122802 no 1730 0.455763440075383 2120 17682924
SGTC_426 0988-0037 14.6 µM 0.110226110655835 0.48884445126505 no 1731 0.456115027566125 2248 5383008
SGTC_554 4483-2211 187 µM 0.110084833190595 0.488812177434405 no 1732 0.456171048203493 2109 747107
SGTC_788 1182-0090 188 µM 0.110017107966268 0.488796706115263 no 1733 0.456197903540136 2197 5715185
SGTC_709 3807-1509 243 µM 0.108871144999532 0.488534922051966 no 1734 0.456652346764005 2207 1886677 YPL242C IQG1
SGTC_2277 7947813 106.88 µM 0.107315872469759 0.48817964313323 no 1735 0.457269196425302 2196 1246798
SGTC_2834 9001755 58.44 µM 0.107074631664918 0.488124536086182 no 1736 0.457364886222288 2063 2989575
SGTC_370 0180-0345 38.7 µM 0.106958055914185 0.488097906570504 no 1737 0.457411127668492 2127 3989527
SGTC_2409 alverine citrate 63.97 µM 0.106239874315079 0.487933852802312 no 1738 0.457696017410846 2163 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_423 5-fluorouracil 457 µM 0.105400235199641 0.487742057161272 no 1739 0.458029114721274 2069 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2712 st079126 47.7 µM 0.103864730510298 0.487391314899116 no 1740 0.458638348328233 2183 3152970
SGTC_1652 st011932 78 µM 0.103245622006137 0.487249899958361 no 1741 0.458884016114398 2215 1551076
SGTC_1783 st039459 87.517 µM 0.102705247232065 0.487126470453984 no 1742 0.459098454491227 2216 729761
SGTC_1350 1495-0454 146 µM 0.102471780814391 0.487073143689231 no 1743 0.459191105283893 2212 1069057
SGTC_1751 st044839 27.194 µM 0.0995701313486191 0.486410388821939 no 1744 0.460342803841599 2258 5291326
SGTC_1227 3909-8010 46.6 µM 0.099286305378013 0.486345563182563 no 1745 0.460455475707066 2137 15982272
SGTC_1038 k292-0204 154 µM 0.0987425949679261 0.486221381140706 no 1746 0.460671324103877 2227 4454212
SGTC_2569 tetrandrine 100 µM 0.0986941166733637 0.486210308889163 no 1747 0.460690570137092 2065 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_909 3448-9333 149 µM 0.0984566551539841 0.486156073767121 no 1748 0.460784844425757 2163 3344074
SGTC_1206 3978-0017 132 µM 0.0976172118125774 0.485964350816948 no 1749 0.461118128366284 2145 3873677
SGTC_2260 7964312 200 µM 0.0969948479077113 0.485822209373827 no 1750 0.461365242966324 2232 231951
SGTC_53 0973-0023 39.979 µM 0.0967850347503916 0.485774290635903 no 1751 0.461448554336972 2264 674768
SGTC_1441 4106-0040 13 µM 0.0960075120350889 0.48559671583188 no 1752 0.46175730319231 2233 2904180
SGTC_2882 9058044 58.44 µM 0.0954026806569167 0.485458583174007 no 1753 0.461997493467945 2098 18076804
SGTC_2226 7298446 200 µM 0.0931579195430797 0.484945935311685 no 1754 0.462889052148703 2246 3283010
SGTC_980 1473-0395 201 µM 0.0930722891460499 0.48492637993634 no 1755 0.462923065957416 2182 768876
SGTC_1791 st048313 56.1 µM 0.0929530566516291 0.484899150925487 no 1756 0.462970427525941 2255 1204976
SGTC_2199 6590217 200 µM 0.0916091436375905 0.484592247693938 no 1757 0.463504293215023 2205 703109
SGTC_1605 st000082 49.1 µM 0.0914472054510573 0.484555267227947 no 1758 0.463568627163381 2211 1114022
SGTC_1755 st041960 45.185 µM 0.0902823473792779 0.484289262290025 no 1759 0.464031423805033 2164 2257073
SGTC_721 1187-1332 279 µM 0.0891980939297422 0.484041670362131 no 1760 0.464462240082484 2229 25730
SGTC_1798 st045719 60.953 µM 0.0880804107629068 0.483786451118108 no 1761 0.464906382902479 2244 3980186
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.087879301255339 0.483740529131233 no 1762 0.464986304075452 2212 364106
SGTC_306 1672-3436 11.6 µM 0.084912134871799 0.483063022278064 no 1763 0.466165622199437 2193 6797378
SGTC_3134 9127454 49.47 µM 0.0843217973143528 0.48292823353779 no 1764 0.466400291183207 2267 24262820
SGTC_3033 9090887 49.47 µM 0.0840175287856679 0.482858762229532 no 1765 0.466521247544059 2193 19325384
SGTC_1525 8-methoxypsoralen 92.5 µM 0.0837229979306928 0.482791514745601 no 1766 0.466638335817126 2268 4114 Related to psoralen; DNA damaging agent.
SGTC_1367 1812-0510 76.9 µM 0.0828764889965521 0.482598241985637 no 1767 0.46697487438902 2211 1142582 YDR527W RBA50
SGTC_88 0180-0332 8.668 µM 0.080306150404901 0.482011414085213 no 1768 0.467996883349749 2277 3101745
SGTC_366 0181-0206 4.31 µM 0.0799589726554599 0.481932153717112 no 1769 0.468134943262749 2261 274874
SGTC_1122 capsaicin 818.572 nM 0.0787606283552425 0.481658578296974 no 1770 0.468611510372256 2193 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2468 5987765 72.9 µM 0.0767111666024725 0.481190717526125 no 1771 0.469426660527631 2189 26772094
SGTC_2076 5212012 200 µM 0.0751524402392151 0.480834901448556 no 1772 0.470046712238836 2281 604802
SGTC_1141 3253-0389 52.6 µM 0.0749851213136655 0.480796707857596 no 1773 0.470113275016657 2258 5402031
SGTC_1519 esterone 74 µM 0.0748367662412645 0.480762843258805 no 1774 0.470172294297201 2152 698 A steroid.
SGTC_323 4013-0906 34.3 µM 0.0726253819357897 0.480258073320435 no 1775 0.471052114093425 2279 2910086
SGTC_2593 nobiletin 86.24 µM 0.0645417985587605 0.478413192359694 no 1776 0.474269413017184 2214 72344 An anti-infammatory.
SGTC_576 1073-0113 22.7 µM 0.0643337805453618 0.478365723250214 no 1777 0.474352228085512 2312 5439563
SGTC_1448 4255-0083 152 µM 0.0640039004831844 0.478290446202899 no 1778 0.474483560520798 2289 5399660
SGTC_1442 4112-3290 3 µM 0.0634464506680433 0.478163240591499 no 1779 0.474705499724351 2294 704353
SGTC_3109 9122853 49.47 µM 0.0601730295074806 0.477416317242423 no 1780 0.476008913057677 2219 1234709
SGTC_65 0798-0905 34.986 µM 0.0594511509727269 0.477251610881552 no 1781 0.476296386244429 2291 3602145
SGTC_2902 5787006 60.46 µM 0.0590597646134868 0.477162312407645 no 1782 0.476452252929491 2266 591003
SGTC_557 1315-0110 16.2 µM 0.0590487902525204 0.477159808520622 no 1783 0.476456623438559 2305 6833801
SGTC_529 4076-0302 30.3 µM 0.0574844053203464 0.476802891031311 no 1784 0.477079664158742 2148 5816522
SGTC_1491 4138-0063 26.5 µM 0.0572469279665738 0.476748711727201 no 1785 0.477174248158026 2321 23883227
SGTC_1715 st032160 10.2275 µM 0.0545114925190001 0.4761246666659 no 1786 0.478263826249353 2285 5289825
SGTC_417 st075190 100 µM 0.0530514239471864 0.475791599663807 no 1787 0.478845467492059 2318 222757
SGTC_1275 0867-0008 21.1 µM 0.0523854243767056 0.475639679196953 no 1788 0.479110793916383 2259 3422836
SGTC_1916 st067606 49.2 µM 0.0520828456246705 0.475570659442267 no 1789 0.479231340810673 2279 19590279
SGTC_3252 9135871 49.47 µM 0.0506382132711512 0.475241141583792 no 1790 0.479806906042378 2304 17682838
SGTC_2756 carbadox 75.1 µM 0.0506115775510359 0.475235066185616 no 1791 0.479817518549293 2278 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2032 5185112 25.99 µM 0.0494223298914111 0.474963814040914 no 1792 0.480291366612025 2304 5718189
SGTC_1812 st052057 4.327 µM 0.049314993467675 0.47493933254781 no 1793 0.48033413549834 2309 3645418
SGTC_1377 2944-0135 198 µM 0.0482667229710734 0.474700246032951 no 1794 0.480751837425911 2295 1894137
SGTC_2088 5278280 127.392 µM 0.0470009359123064 0.47441156111782 no 1795 0.481256240802262 2270 791502
SGTC_308 4092-1169 104 µM 0.0461384196642811 0.474214856863631 no 1796 0.481599962068183 2295 2268590 YDL196W YDL196W
SGTC_1664 st014217 9.02 µM 0.0447147248116732 0.473890184772462 no 1797 0.482167348367634 2322 3982782
SGTC_485 niflumic acid 177 µM 0.0423318660551533 0.473346815287476 no 1798 0.483117071303965 2320 4488 A COX2 inhibitor.
SGTC_1809 st050081 57.6 µM 0.0414660339864858 0.473149389576641 no 1799 0.483462185252559 2298 5036894
SGTC_2623 humulene 100 µM 0.0409662415469593 0.473035430664339 no 1800 0.483661404300483 2288 6187145 An anti-inflammatory.
SGTC_1579 chlormadinone acetate 49.4 µM 0.0377301145557333 0.472297607149845 no 1801 0.484951432570991 2344 45114258 A steroidal progestin.
SGTC_1249 0481-0015 10.2 µM 0.0361187543686856 0.471930259008087 no 1802 0.485593834130209 2325 4227577
SGTC_2728 chlorpromazine 9.18 µM 0.0341200441220956 0.471474638355668 no 1803 0.486390712445945 2353 2726 A thorazine and dopamine antagonist.
SGTC_1264 0783-0040 158 µM 0.0335760880498144 0.471350646018842 no 1804 0.486607595243198 2326 2855798
SGTC_1389 3405-0187 19 µM 0.0307703862025117 0.470711143284196 no 1805 0.487726328809501 2321 799890
SGTC_411 enrofloxacin 100 µM 0.0307148850653025 0.470698493683889 no 1806 0.487748460099023 2347 71188 A bacterial gyrase inhibitor.
SGTC_1553 gossypol 38.6 µM 0.0257575751609401 0.469568763927207 no 1807 0.489725350364213 2349 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_442 cape 100 µM 0.0248933315521834 0.469371834803558 no 1808 0.490070023119002 2354 5281787
SGTC_44 0929-0055 61.211 µM 0.0238397989737337 0.469131783869492 no 1809 0.490490197035558 2332 1379590
SGTC_1417 3966-0327 90.4 µM 0.023021571472555 0.468945355723877 no 1810 0.49081653298064 2350 651118
SGTC_20 0481-0013 4.944 µM 0.0172200524806657 0.467623712664332 no 1811 0.493130532497179 2367 182045
SGTC_1438 4092-1045 4 µM 0.0167403868987246 0.467514455900547 no 1812 0.493321863791375 2367 1351342
SGTC_795 0685-0265 78 µM 0.0164627325936498 0.467451213767259 no 1813 0.493432616569212 2384 302754
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.0162678763865595 0.467406831289478 no 1814 0.493510342539591 2371 6708561
SGTC_2496 diffractaic acid 79.83 µM 0.0157925932185207 0.467298577549006 no 1815 0.493699928728303 2372 94870 An apoptosis inducer which activates caspases.
SGTC_1963 st076565 50.3 µM 0.0136166185079033 0.466802993693375 no 1816 0.494567923023933 2375 4914280
SGTC_3028 9087778 49.47 µM 0.0129084770374585 0.466641723707687 no 1817 0.494850405746331 2390 17217395
SGTC_739 1486-1183 203 µM 0.012461825303846 0.466540007414542 no 1818 0.495028579670171 2379 4346692
SGTC_1226 3909-7979 35.4 µM 0.0118501241834284 0.466400707863125 no 1819 0.495272595076804 2383 6615510
SGTC_2899 9053889 58.44 µM 0.00878932549739754 0.465703750076201 no 1820 0.496493611588997 2389 6470052
SGTC_1899 st063254 59.6 µM 0.00795828253780709 0.46551453587913 no 1821 0.496825138129245 2393 3093813
SGTC_1093 fluphenazine 7.97 µM 0.0067955565272163 0.465249816246428 no 1822 0.497288986048036 2395 6602611 An atypical antipsychotic.
SGTC_2913 7966556 36.57 µM 0.00648842635736111 0.465179894007356 no 1823 0.497411510555218 2393 2976516
SGTC_2302 7771753 200 µM 0.00601437672417856 0.465071972459217 no 1824 0.497600625299793 2385 2203047
SGTC_2955 9076254 12.21 µM 0.00529248731054451 0.464907632953466 no 1825 0.497888612900148 2394 16459619
SGTC_2426 5582046 32.21 µM 0.00432249126255765 0.464686820927773 no 1826 0.498275580848523 2396 2251934
SGTC_2350 9023895 38.85 µM 0.00229751188903687 0.464225885312986 no 1827 0.499083426174103 2396 2997209
SGTC_2411 st077133 39.94 µM 0.000504665259705286 0.463817828927148 no 1828 0.499798667699 2404 1403142 YNL221C POP1
SGTC_3153 9100258 49.47 µM -0.00161990089442138 0.463334321653968 no 1829 0.499353753325789 2411 25236848
SGTC_2326 6164455 177.58 µM -0.00395371784369258 0.462803255678536 no 1830 0.498422698896739 2416 2888790
SGTC_347 4534-1311 26.2 µM -0.00461326713807817 0.462653185534568 no 1831 0.498159579215881 2412 2862016
SGTC_2857 9024691 58.44 µM -0.00614796230963632 0.462304010221526 no 1832 0.497547333347135 2429 16478292
SGTC_913 3487-1245 167 µM -0.00708133346099009 0.462091662912977 no 1833 0.497174980291045 2421 4016153
SGTC_3045 9092950 49.47 µM -0.00820058801912297 0.461837040311361 no 1834 0.496728475383204 2423 44120432
SGTC_368 fentichlor 4.58 µM -0.0105986961940598 0.461291540224552 no 1835 0.495771811131614 2425 7329 A pesticide.
SGTC_140 0062-0056 502.533 µM -0.0142245320747295 0.460466906292161 no 1836 0.494325424100182 2432 3758964
SGTC_2162 5663267 200 µM -0.0155244232532137 0.460171309640827 no 1837 0.493806899950596 2439 6456493
SGTC_2586 curcumin 80 µM -0.0161081057380259 0.4600385867673 no 1838 0.493574073455466 2446 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1470 k295-0292 231 µM -0.0172718888707328 0.459773968793974 no 1839 0.49310985584461 2495 5045612
SGTC_163 TUB2.036 7.546 µM -0.0178544930552503 0.459641504459295 no 1840 0.492877466250824 2432 15992207 YJR013W GPI14
SGTC_2078 5212016 200 µM -0.018089171894298 0.459588147754753 no 1841 0.492783858058152 2436 1899708
SGTC_2606 farnesol 9.78 µM -0.0187326136089908 0.459441858243783 no 1842 0.492527205458907 2447 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2115 tiliquinol 12.7705 µM -0.0212212141555482 0.458876115029718 no 1843 0.491534595821588 2485 71208 A bioactive hydroxyquinoline.
SGTC_2769 toremifene 3.73 µM -0.0216457208874858 0.458779618551046 no 1844 0.4913652810347 2472 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2418 pentamidine 31.67 µM -0.0237792227004274 0.458294679832691 no 1845 0.490514356623247 2439 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2399 5884133 200 µM -0.0239730715163595 0.458250621629283 no 1846 0.490437044174597 2461 722445
SGTC_1900 st060200 72.8 µM -0.0247695853685884 0.458069594345893 no 1847 0.490119375485932 2443 688945
SGTC_2667 digitoxin 100 µM -0.0247698852398786 0.458069526194433 no 1848 0.490119255891289 2454 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1150 3909-7983 10.9 µM -0.0253137404107781 0.457945926781806 no 1849 0.489902357090331 2464 23965914
SGTC_1588 farnesol 29.9 µM -0.0270490438199814 0.457551579765603 no 1850 0.48921030850617 2460 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1832 st054113 55 µM -0.0289192342370917 0.457126626526736 no 1851 0.488464502666975 2456 1251267
SGTC_512 prima-1 270 µM -0.0289291342947635 0.457124377120256 no 1852 0.48846055476716 2487 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.0312109061642094 0.456605969210145 no 1853 0.487550671145676 2482 4213774
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.0312137081512737 0.456605332656991 no 1854 0.487549553858934 2465 688803
SGTC_2912 7964298 10.93 µM -0.0319146581509952 0.456446094905731 no 1855 0.48727005454026 2491 2975850
SGTC_2690 usnic acid 100 µM -0.0322050470257885 0.456380128094686 no 1856 0.487154265661928 2487 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3034 9090421 49.47 µM -0.0323662235238537 0.456343514608804 no 1857 0.48708999904559 2450 17173761
SGTC_63 0099-0242 26.702 µM -0.0329877838800423 0.456202321992539 no 1858 0.486842164696095 2470 3898502 YLR359W ADE13
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.0361860213176233 0.455475903521236 no 1859 0.485567016031499 2513 75037 A free radical scavenger.
SGTC_1911 st060208 74.3 µM -0.0376684021489024 0.45513925939507 no 1860 0.484976034770342 2519 688783
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.0379868481452391 0.45506694548404 no 1861 0.484849084060155 2500 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1965 Pectolinarigenin 58.4 µM -0.0389184130160001 0.454855410797116 no 1862 0.484477718112939 2477 5320438 An anti-inflammatory.
SGTC_1496 4469-0713 57.4 µM -0.0397329188164062 0.454670467734784 no 1863 0.484153028485141 2473 746691
SGTC_711 k292-0785 179 µM -0.0399027288268344 0.454631911623561 no 1864 0.484085337774129 2480 4146315
SGTC_1714 st033236 13.627 µM -0.0423431048033801 0.454077860891579 no 1865 0.483112591708672 2515 2916566
SGTC_1555 citronellol 128 µM -0.0430494970305512 0.45391750176755 no 1866 0.482831038737438 2472 8842 A terpine precursor.
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.0431333425023483 0.453898468383628 no 1867 0.482797620275013 2482 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1217 1183-1422 255 µM -0.0433685042931608 0.453845085926892 no 1868 0.48270389200119 2520 2849664
SGTC_1148 3909-7663 27.7 µM -0.0457275651704414 0.453309618080047 no 1869 0.481763696477893 2598 4084526
SGTC_568 1193-0097 7.48 µM -0.0464459016161647 0.453146584387009 no 1870 0.481477425883288 2491 3646150
SGTC_2938 9059746 27.26 µM -0.0474734404577477 0.452913387829549 no 1871 0.481067948953075 2543 6471769
SGTC_863 0466-0191 129 µM -0.0492933509852934 0.452500405026113 no 1872 0.480342759111666 2489 765160 YPR165W RHO1
SGTC_1621 st003705 32.4 µM -0.0507839825869051 0.452162182029324 no 1873 0.479748827225413 2481 24207032
SGTC_2815 7968870 71.43 µM -0.0508294550357219 0.452151864915149 no 1874 0.479730709741621 2508 2977326 YHR190W ERG9
SGTC_733 4069-0007 56.1 µM -0.0522339744005417 0.451833213469026 no 1875 0.479171131108217 2493 5717425 YNL287W SEC21
SGTC_419 nsc-638432 893 µM -0.0531849740633601 0.451617472270258 no 1876 0.478792263815406 2544 368090
SGTC_1839 st053978 48 µM -0.0556968377395579 0.451047706580435 no 1877 0.477791659356128 2489 3788398
SGTC_1339 1486-1321 22.7 µM -0.0571085529549121 0.450727531603768 no 1878 0.47722936163593 2527 3469382
SGTC_1060 3448-7350 82 µM -0.0580499706169161 0.450514037239779 no 1879 0.47685441240429 2526 570178
SGTC_2164 5685496 200 µM -0.0586491845162762 0.450378155177107 no 1880 0.476615767248765 2511 759046
SGTC_2726 cimetidine 79.27 µM -0.0592290658067816 0.450246662654012 no 1881 0.4763848295542 2503 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2163 5671233 125 µM -0.0597449049600751 0.450129696765546 no 1882 0.476179403301169 2521 701023
SGTC_1539 benzyladenosine 56 µM -0.0601581809342567 0.450035990075824 no 1883 0.476014826069392 2511 92208 A nucleotide analog.
SGTC_2182 6325192 200 µM -0.0631731301012455 0.449352461504794 no 1884 0.474814320551552 2509 736248
SGTC_759 3486-0358 89.3 µM -0.0650719149533785 0.448922059031277 no 1885 0.474058370823044 2521 875103
SGTC_228 caffeine 993.056 µM -0.0672251780563031 0.448434046063101 no 1886 0.473201220634701 2529 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_682 0kpi-0099 17 µM -0.0677681344516826 0.448311003364584 no 1887 0.472985105225078 2587 1714895 YML126C ERG13
SGTC_1977 st070720 65.3 µM -0.0695868871395715 0.44789888088817 no 1888 0.47226123709272 2624 682188
SGTC_2838 9002687 71.43 µM -0.0716674636137492 0.447427499115984 no 1889 0.471433274915446 2532 6457060
SGTC_713 1488-1073 324 µM -0.0726595089423287 0.447202764391021 no 1890 0.471038535262156 2524 3312542
SGTC_1632 st005650 90 µM -0.0735797449401459 0.446994312271959 no 1891 0.470672394319576 2615 2759605
SGTC_3298 9116858 71.43 µM -0.0736682462343224 0.446974265704647 no 1892 0.470637182972334 2620 2506942
SGTC_1670 st016595 4.04 µM -0.075205401727407 0.446626103853274 no 1893 0.470025643285666 2529 597879
SGTC_1943 st076331 65.2 µM -0.0761340759913787 0.446415781386201 no 1894 0.469656215042064 2542 24208415
SGTC_3003 9075612 71.4286 µM -0.0764063003155651 0.44635413195429 no 1895 0.469547928666799 2610 6501993
SGTC_1164 k060-0068 93.7 µM -0.0768574548466591 0.446251963850178 no 1896 0.469368471750616 2544 5963676
SGTC_2130 NSC 7 2.4545 µM -0.0770337102277537 0.446212050162629 no 1897 0.469298363875673 2580 21448
SGTC_1459 k035-0031 35.7 µM -0.0778314451725156 0.446031406934385 no 1898 0.46898106634024 2531 3877128 YMR208W ERG12
SGTC_2083 5306046 65.942 µM -0.0783483572394799 0.445914360669812 no 1899 0.468775476068464 2566 539837
SGTC_2185 6113692 200 µM -0.0791326210017593 0.445736785999553 no 1900 0.468463568526429 2623 874150
SGTC_2610 ononetin 44.17 µM -0.0794654803995815 0.445661422554367 no 1901 0.468331193703729 2602 259632
SGTC_506 n9-isopropylolomoucine 153 µM -0.0797535459274842 0.445596202574778 no 1902 0.468216635776725 2538 6610355
SGTC_2441 5730946 39.09 µM -0.0798169876628367 0.445581839135505 no 1903 0.468191406614581 2647 1774275
SGTC_1570 verbenone 133 µM -0.0821468632158452 0.445054396480688 no 1904 0.467264963782817 2595 29025 A natural terpanoid with antifungal properties.
SGTC_2605 digitonin 300 nM -0.0830302651242445 0.444854435277484 no 1905 0.46691373730249 2548 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1739 st037196 92.5 µM -0.0838792793551908 0.444662271071532 no 1906 0.466576207086338 2579 612214
SGTC_3260 9137109 49.47 µM -0.0851926846170469 0.444365023153148 no 1907 0.466054103134586 2515 17478346
SGTC_797 k781-0471 270 µM -0.0855141177559773 0.444292281644278 no 1908 0.465926336118694 2615 23738129
SGTC_597 k018-0003 82.8 µM -0.0871218364423372 0.443928477168268 no 1909 0.465287334203559 2647 6786234
SGTC_1453 4237-0541 195 µM -0.0898213414320926 0.443317722988825 no 1910 0.464214594363855 2566 739892
SGTC_2213 7173844 200 µM -0.089951775575787 0.443288216088406 no 1911 0.464162768458752 2565 892728
SGTC_1321 1326-2144 215 µM -0.093105938622583 0.44257477531494 no 1912 0.462909699796945 2673 3513030
SGTC_2707 st078556 66.6 µM -0.0935678914208306 0.442470301694435 no 1913 0.462726208307807 2618 17250899
SGTC_1362 1611-0397 101 µM -0.0964095619439468 0.441827727748597 no 1914 0.461597649084149 2591 27816
SGTC_374 0880-0231 82.3 µM -0.0968321459685791 0.441732183789805 no 1915 0.461429847544984 2627 6833587
SGTC_534 k292-0788 63.4 µM -0.0971143843751109 0.441668373102905 no 1916 0.461317778888989 2559 4146317
SGTC_564 3555-0129 330 µM -0.0972456320616107 0.441638700105474 no 1917 0.461265665298757 2579 563260
SGTC_120 rhodamine 6G 52.259 µM -0.0973654521282484 0.441611610995655 no 1918 0.461218089773451 2593 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_734 2023-0417 80 µM -0.101373799413133 0.440705555679153 no 1919 0.459626867174929 2686 3935732
SGTC_1503 4585-0012 61.3 µM -0.1013861932197 0.440702754635663 no 1920 0.4596219481054 2770 2922052
SGTC_3344 9148862 3.898 µM -0.101457304475826 0.440686683301225 no 1921 0.459593724352656 2676 4905352
SGTC_325 2810-4341 181 µM -0.101986802919199 0.440567018307964 no 1922 0.4593835751027 2655 774970
SGTC_1395 3486-0190 4.35 µM -0.102030070413342 0.440557240229243 no 1923 0.459366403444484 2604 6748079
SGTC_3041 9091929 49.47 µM -0.103866972162012 0.440142149861338 no 1924 0.45863745884945 2687 25236887
SGTC_272 doxorubicin 8.13 µM -0.10512825416639 0.439857172128754 no 1925 0.458137019970094 2566 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_813 k007-0158 173 µM -0.10549189776398 0.439775015214494 no 1926 0.457992749382652 2660 6523916
SGTC_1622 st003707 19.4 µM -0.10670397665079 0.439501192592074 no 1927 0.457511913855245 2702 10140899
SGTC_1134 3477-0009 42.5 µM -0.106863560397032 0.439465142933623 no 1928 0.457448611095986 2787 3973534
SGTC_448 monastrol 171 µM -0.108232020222721 0.439156031155332 no 1929 0.456905822836786 2628 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_61 0978-8327 98.565 µM -0.108595025337138 0.439074040697848 no 1930 0.456761853312701 2608 6150059 YHR072W ERG7
SGTC_2229 7354935 190 µM -0.109110025106306 0.438957724324657 no 1931 0.456557611740197 2598 318112
SGTC_1383 3049-0032 20.7 µM -0.109117096003476 0.43895612734873 no 1932 0.456554807602845 2710 712864
SGTC_1018 4259-0013 28.1 µM -0.109383537441205 0.43889595175436 no 1933 0.45644914530684 2747 6801262
SGTC_812 4251-0442 148 µM -0.112473554300229 0.438198177334624 no 1934 0.455223968642246 2586 5723007
SGTC_1338 1486-1223 76 µM -0.114157301069145 0.43781804153874 no 1935 0.454556549688126 2686 3444526
SGTC_1932 st074806 40.9 µM -0.117301698049784 0.437108291862895 no 1936 0.453310489736455 2849 17251235
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.117378123892149 0.43709104361935 no 1937 0.453280209415472 2641 279621
SGTC_2220 6782180 200 µM -0.118638417604444 0.436806630225972 no 1938 0.452780913716511 2621 833803
SGTC_659 k018-0002 107 µM -0.119684021112141 0.436570691249727 no 1939 0.452366729334931 2669 6797879 YHR007C ERG11
SGTC_906 1165-0455 526 µM -0.120698841422437 0.436341720035187 no 1940 0.451964788349255 2607 3252859
SGTC_1958 st076513 41.9 µM -0.122207615833303 0.43600133871961 no 1941 0.451367297551892 2618 732122 YGL099W LSG1
SGTC_1830 st055982 50.3 µM -0.122470063824179 0.435942134970505 no 1942 0.451263376551331 2611 455313 An antimicrobial agent.
SGTC_2717 st081029 62.2815 µM -0.122921702745504 0.435840256365266 no 1943 0.451084549824141 2636 5292846
SGTC_541 4513-1321 94 µM -0.123994824636738 0.435598203612962 no 1944 0.450659686391286 2648 747515
SGTC_3199 9111318 49.47 µM -0.125794927336966 0.435192227710881 no 1945 0.449947128637502 2718 8548020
SGTC_3347 9188721 44.724 µM -0.127217248634991 0.434871500868615 no 1946 0.449384226932445 2710 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2794 7785382 27.27 µM -0.128027302553018 0.434688856613098 no 1947 0.449063683260755 2605 2205081
SGTC_5 0352-0601 109.883 µM -0.130502341396513 0.434130891840499 no 1948 0.44808450090952 2642 762456
SGTC_898 1000-0849 28.3 µM -0.132341151930609 0.433716441211047 no 1949 0.447357229538292 2612 6751807
SGTC_2154 5570129 200 µM -0.134024088176316 0.433337187033231 no 1950 0.446691763331501 2628 673366
SGTC_3070 9117005 49.47 µM -0.136343653395689 0.432814567483255 no 1951 0.445774807826335 2638 8779016
SGTC_3320 9137005 35.139 µM -0.138819228550869 0.432256927083613 no 1952 0.444796499459585 2711 4908713
SGTC_3155 9099265 49.47 µM -0.138976077949502 0.432221600206906 no 1953 0.444734526305828 2755 25236499
SGTC_1061 3448-9325 110 µM -0.139946616554746 0.432003019796754 no 1954 0.44435108449587 2614 723482
SGTC_3002 9075603 71.4286 µM -0.140687714003283 0.431836127119477 no 1955 0.44405832567969 2661 20105405
SGTC_101 0490-5701 117.494 µM -0.141836721849096 0.431577398441029 no 1956 0.443604488720876 2637 4661669
SGTC_2276 7947513 42.08 µM -0.142031275861136 0.431533592502319 no 1957 0.44352765077104 2750 2105100
SGTC_244 nsc-207895 1.295 µM -0.144345940052327 0.43101248558898 no 1958 0.442613651606293 2632 42640
SGTC_3054 9094397 49.47 µM -0.144973657273822 0.430871186490355 no 1959 0.44236583524261 2700 2598354
SGTC_2671 danthron 100 µM -0.145887248480063 0.430665552995097 no 1960 0.44200519906283 2697 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_478 N-arachidonylglycine 10 µM -0.145961829158307 0.430648767010386 no 1961 0.441975760780425 2653 5283389
SGTC_1865 st057639 52.2 µM -0.14815894101987 0.430154316104901 no 1962 0.441108667224795 2638 688818
SGTC_1153 4055-0057 267 µM -0.149754625423009 0.429795282553538 no 1963 0.440479104609092 2677 882706
SGTC_1354 1498-1681 81 µM -0.149836125072342 0.429776946455202 no 1964 0.44044695369582 2750 5754243
SGTC_1043 0916-0009 19.3 µM -0.15150338439638 0.429401873467134 no 1965 0.43978932064643 2671 3101130
SGTC_1174 0739-0097 51.1 µM -0.152168273285852 0.429252315292361 no 1966 0.439527108385355 2726 728447
SGTC_1620 st003704 16.5 µM -0.153320076983729 0.428993255960809 no 1967 0.439072934357038 2692 2834414
SGTC_192 3455-0609 60.9 µM -0.155838380968361 0.428426955238235 no 1968 0.438080208280246 2794 3769639
SGTC_3068 9116768 49.47 µM -0.156768752788913 0.42821777615319 no 1969 0.43771354998365 2771 41904888
SGTC_2215 7188065 200 µM -0.15869533706493 0.427784678966976 no 1970 0.43695445605283 2814 940217
SGTC_2596 sinensetin 100 µM -0.159077394082101 0.427698802663028 no 1971 0.436803949160498 2753 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_887 0885-0007 9.62 µM -0.16035855059206 0.42741085761546 no 1972 0.436299319428092 2839 5719458
SGTC_3053 9095903 49.47 µM -0.160474098890934 0.427384889571889 no 1973 0.436253811644365 2693 17174018
SGTC_2243 6634756 200 µM -0.162200641418135 0.426996908137604 no 1974 0.435573927355079 2981 885676
SGTC_1886 st057356 49.9 µM -0.163076941677653 0.426800016589259 no 1975 0.435228927312103 2672 24207747
SGTC_114 0364-0001 490.298 µM -0.164849805238023 0.426401736511221 no 1976 0.434531100679575 2757 4003655
SGTC_2873 9040596 71.43 µM -0.165067056646446 0.426352935366236 no 1977 0.434445601133232 2808 6463863
SGTC_62 0180-0423 3.232 µM -0.166680621386814 0.425990515945111 no 1978 0.433810677054348 2736 30102 YGL099W LSG1
SGTC_1482 3346-2049 8.48 µM -0.166835910972284 0.425955639966494 no 1979 0.43374958089698 2795 3826804
SGTC_1976 st070609 63.5 µM -0.16712169706582 0.425891457719087 no 1980 0.433637147152603 2631 682556
SGTC_1155 4088-0394 48.2 µM -0.168125013613917 0.425666147017142 no 1981 0.433242465707726 2682 2326248
SGTC_3240 9133527 49.47 µM -0.16856207367244 0.425568005808081 no 1982 0.433070557217087 2722 17617455
SGTC_1880 MG-132 525 µM -0.168937970341483 0.425483602438541 no 1983 0.432922716203277 2784 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2709 st078560 56 µM -0.169919364199054 0.425263257589789 no 1984 0.432536776072445 2810 17250903
SGTC_2773 thioridazine 9.09 µM -0.170314420546684 0.425174565198548 no 1985 0.432381435493661 2678 5452 An antipsychotic.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.170689051742094 0.42509046186806 no 1986 0.432234135968001 2660 4000243
SGTC_2353 9059630 146.67 µM -0.172306296336568 0.42472743555516 no 1987 0.431598367312839 2822 4779114
SGTC_1732 st034308 51.822 µM -0.173361453240792 0.424490616645121 no 1988 0.431183661075855 2660 830119
SGTC_1429 4049-0205 9.46 µM -0.173382436616731 0.424485907422401 no 1989 0.431175414788731 2698 22774478
SGTC_157 1348-1695 65.819 µM -0.174648545949836 0.424201779083116 no 1990 0.430677900306365 2715 5380510
SGTC_2699 st077704 54.6 µM -0.174774558523118 0.424173502680408 no 1991 0.430628389988338 2768 645852
SGTC_1467 k284-1082 293 µM -0.175225717353969 0.424072268771437 no 1992 0.430451138708347 2824 3334705
SGTC_185 k048-0037 25.491 µM -0.175374928312773 0.42403878896264 no 1993 0.430392519789025 2712 6827589
SGTC_1701 st028638 40.4 µM -0.176284801666473 0.423834644343307 no 1994 0.430035100782703 2798 3490878
SGTC_2718 lomofungin 53.02 µM -0.178817054603794 0.423266600713113 no 1995 0.429040676741467 2863 5351222 A RNA synthesis inhibitor.
SGTC_986 1493-0483 84 µM -0.180250092596134 0.422945207314463 no 1996 0.428478117092037 2728 40079
SGTC_2754 granisetron 64.02 µM -0.18042214095613 0.422906624755748 no 1997 0.428410586783791 2846 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3184 9108758 49.47 µM -0.181515858115996 0.422661371450659 no 1998 0.427981343462282 2691 902885
SGTC_2572 astragaloside iv 100 µM -0.18199909608416 0.422553020519967 no 1999 0.427791717637505 2909 45006101 An anti-inflammatory agent.
SGTC_3067 9117431 49.47 µM -0.182460486861809 0.422449573603426 no 2000 0.427610680359198 2772 17150885
SGTC_1660 st012960 28.1 µM -0.183163898941922 0.422291874177982 no 2001 0.427334709799653 2811 24207266
SGTC_2149 5554786 194.827 µM -0.183946049951326 0.422116536734308 no 2002 0.427027889247382 2738 745063 YPR165W RHO1
SGTC_1091 telmisartan 47.6 µM -0.185740164367716 0.421714402386775 no 2003 0.426324264863631 2835 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2747 doxorubicin 7.63 µM -0.186995386565634 0.421433104308762 no 2004 0.425832125067019 2722 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2972 9093619 59.92 µM -0.187372069237584 0.421348696701281 no 2005 0.425684460139891 2760 25236256
SGTC_2075 5212009 200 µM -0.189684082172367 0.420830696754612 no 2006 0.424778347469353 2854 780898
SGTC_959 1222-0044 107 µM -0.191683912991496 0.420382750823066 no 2007 0.423994903944754 2813 6083612
SGTC_701 4424-0219 185 µM -0.192214535431199 0.420263912969887 no 2008 0.42378708028403 2878 2911779
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.192853430401878 0.420120836116945 no 2009 0.423536878717565 2753 2724 A muscle relaxant with antifungal properties.
SGTC_217 ketoconazole 989 nM -0.196546840907656 0.419293925545471 no 2010 0.422091086908782 2825 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1929 genistein trimethyl ether 50.5 µM -0.196586717823086 0.41928499951746 no 2011 0.422075482713395 2892 136420
SGTC_1065 prochlorperazine maleate 2.48 µM -0.198507964759081 0.41885499789773 no 2012 0.421323826885866 2763 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2450 5739737 12.93 µM -0.199238495467577 0.41869152043395 no 2013 0.42103809399324 2838 2262825
SGTC_1380 2291-0730 164 µM -0.20136955718541 0.418214713798762 no 2014 0.420204808737618 2849 2999191
SGTC_3026 9090633 49.47 µM -0.203882736701421 0.417652566073506 no 2015 0.419222567923366 2753 25236842
SGTC_1707 st032323 6.317 µM -0.204197831006771 0.417582097658451 no 2016 0.419099453127456 2771 3132057 YMR211W DML1
SGTC_1066 ketoconazole 628 nM -0.204236008936443 0.417573559638188 no 2017 0.419084536645354 2918 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_846 0335-0850 148 µM -0.204268167441891 0.417566367817615 no 2018 0.419071972100088 2771 6819598
SGTC_1966 st070145 16.1 µM -0.208370205432638 0.4166492286516 no 2019 0.41746995918045 2744 3748532
SGTC_2103 5378138 10 µM -0.212336647489377 0.415762837402219 no 2020 0.415922203329419 2777 244142
SGTC_933 2914-0560 114 µM -0.220603225649803 0.413916865207831 no 2021 0.412700694616519 3000 463887
SGTC_164 4100-3994 89.624 µM -0.225429258818536 0.412840061489621 no 2022 0.41082267605843 2850 4615967
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.225788525789388 0.412759926530527 no 2023 0.41068295087205 2811 5106787 A p450 inhibitor.
SGTC_684 1140-0066 328 µM -0.226536941831445 0.412593003050685 no 2024 0.4103919152469 2874 6813534
SGTC_782 0083-0095 30.5 µM -0.227343652531742 0.412413095484173 no 2025 0.410078265907625 2768 3591729 An indicator and reagent.
SGTC_71 0417-1750 47.813 µM -0.227783725898469 0.412314960833621 no 2026 0.409907189497695 3024 6811472
SGTC_1523 st012844 44.7 µM -0.228336482093283 0.412191706118143 no 2027 0.409692332479307 2926 4274103
SGTC_2561 acetosyringone 100 µM -0.230044600264476 0.411810881191065 no 2028 0.409028556469216 2783 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2805 7950783 58.44 µM -0.234877150423513 0.410733915168362 no 2029 0.407152042416044 2938 1178958 YDL195W SEC31
SGTC_187 1488-2104 32.728 µM -0.237263429092549 0.410202364617602 no 2030 0.406226215741014 2889 2852859
SGTC_2566 crystal violet carbinol 226 nM -0.237403050468233 0.410171268646232 no 2031 0.406172061719752 3003 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.237494680660002 0.410150861405957 no 2032 0.406136522697668 2832 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1864 st057645 30.4 µM -0.237667069147095 0.410112468898268 no 2033 0.406069663444867 2846 688666
SGTC_1871 st057448 67.3 µM -0.238044561846822 0.410028400798326 no 2034 0.405923266022184 3012 691747
SGTC_1194 1488-0194 225 µM -0.238329903665705 0.40996485755969 no 2035 0.405812614844389 2812 1391452
SGTC_2646 retinol 96.75 µM -0.239737329793424 0.409651470144196 no 2036 0.405266946846731 2899 445354 A vitamin A analog and teratogen.
SGTC_3202 9113761 49.47 µM -0.239855102117499 0.409625248743045 no 2037 0.405221294105352 3013 4798415
SGTC_769 0302-0231 76 µM -0.241249701427218 0.409314779157954 no 2038 0.404680796027266 2920 571869 YER009W NTF2
SGTC_2395 5646831 180.19 µM -0.244059286641158 0.408689474355441 no 2039 0.403592451872352 3011 6808628
SGTC_1149 3909-7961 23.3 µM -0.244323245842252 0.40863073918155 no 2040 0.403490240665616 2845 735261
SGTC_2254 7938975 95.19 µM -0.244565044142763 0.408576936965895 no 2041 0.403396616464953 3046 2969277
SGTC_2798 7813637 45.45 µM -0.244784677188224 0.40852806820472 no 2042 0.403311579439965 2976 956368
SGTC_1665 st014639 11.4 µM -0.251118900699243 0.407119306628763 no 2043 0.400861091686025 2877 981133 YIL048W NEO1
SGTC_884 0851-0618 334 µM -0.254059109834152 0.406465796975425 no 2044 0.399724946360031 2996 9642473
SGTC_824 1304-0008 100 µM -0.255042333704042 0.406247317379217 no 2045 0.399345201263185 2871 768245
SGTC_989 1501-0895 10.3 µM -0.255555502721317 0.406133299026707 no 2046 0.399147040636638 2932 2830112
SGTC_1293 1000-1278 195 µM -0.258570886681784 0.405463487677951 no 2047 0.397983174264579 3000 678847
SGTC_2138 5575593 77.673 µM -0.259608140292958 0.405233144993046 no 2048 0.397583028265716 2874 762213
SGTC_2832 7992762 51.95 µM -0.263212675877375 0.404432942255803 no 2049 0.396193330625114 2837 2985177
SGTC_2638 epoxomicin 18 µM -0.26398132507497 0.404262354601 no 2050 0.395897154456949 2980 9915668 A protesome inhibitor.
SGTC_807 1315-0151 48 µM -0.266906635171818 0.403613302150326 no 2051 0.394770523896756 3110 4011080
SGTC_991 3996-0057 64.7 µM -0.267543846934353 0.403471956083552 no 2052 0.394525229569822 2965 715343
SGTC_1266 0828-0227 32.9 µM -0.267709418424079 0.403435231142587 no 2053 0.394461499753824 2992 3913820
SGTC_1565 sinapyl alcohol 95.1 µM -0.267921753376672 0.403388134977281 no 2054 0.39437977443417 2964 5280507 A phenol propionate derived from cinnamic acid.
SGTC_785 1270-0111 65.3 µM -0.268028609305393 0.40336443472492 no 2055 0.394338648555115 2848 6741994
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.268224725895092 0.403320937709454 no 2056 0.394263171791805 2917 4330530
SGTC_1113 artemisinin 1.17947 µM -0.269211284594604 0.403102145412814 no 2057 0.393883548443503 2984 2240 An anti-malaria and mitochondrial poison.
SGTC_2807 7945238 51.95 µM -0.269295301678028 0.403083514074577 no 2058 0.393851223701255 2971 17148797
SGTC_1924 st058459 75.1 µM -0.270627294800247 0.402788165302465 no 2059 0.393338850363526 2845 688683
SGTC_2322 7413319 38.22 µM -0.271246633978396 0.402650855346293 no 2060 0.393100674076666 3016 1840400
SGTC_1071 trifluoperazine 6.31 µM -0.275401843118861 0.401729940291502 no 2061 0.39150376410676 3043 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1796 st049173 110.4 µM -0.27597607856077 0.401602715817968 no 2062 0.391283219771349 2986 94134
SGTC_1330 1469-0054 61.8 µM -0.27718894087921 0.401334034946668 no 2063 0.390817515479733 3040 7102664
SGTC_1910 st062352 60.4 µM -0.277197604613893 0.401332115869441 no 2064 0.390814189416814 2847 2245730
SGTC_2790 5423970 71.43 µM -0.278634759329283 0.401013809125925 no 2065 0.390262567305378 3079 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2107 5363541 170.161 µM -0.278863313306611 0.400963194131239 no 2066 0.390174861915184 2960 244052
SGTC_2131 toluylene red 5.2905 µM -0.279330961572176 0.400859635092204 no 2067 0.389995423816132 2927 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1612 st002233 45.4 µM -0.279350879058321 0.400855224590621 no 2068 0.389987781934662 2909 1035021
SGTC_1244 0416-0015 52.5 µM -0.279783854214232 0.40075935027353 no 2069 0.389821669836089 2917 96201
SGTC_1896 st058441 89 µM -0.281932947470479 0.4002835620121 no 2070 0.38899746271427 2946 688759
SGTC_1318 1280-3875 124 µM -0.281977858730071 0.400273620673574 no 2071 0.388980243935524 2964 373245
SGTC_1347 1493-0251 600 nM -0.283153881904832 0.400013324906532 no 2072 0.388529439548874 3034 3986378
SGTC_3262 9137218 49.47 µM -0.284452064238651 0.399726042552389 no 2073 0.388031982261313 2825 17650664
SGTC_1927 st060202 13.8 µM -0.287585428768567 0.399032865876902 no 2074 0.386832050023852 2882 688887
SGTC_2863 9028737 58.44 µM -0.288254900735014 0.398884803538339 no 2075 0.386575813297139 3011 6460917
SGTC_247 mechlorethamine 29.705 µM -0.289999689433214 0.398498989490801 no 2076 0.385908237597449 2903 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_234 nsc-17383 10.7 µM -0.2925034761816 0.397945516397549 no 2077 0.384950851218516 3069 408974
SGTC_1937 st074714 47.2 µM -0.293988269352421 0.397617393230347 no 2078 0.384383433599257 2876 17250970
SGTC_3115 9123671 49.47 µM -0.29516461281836 0.397357485503921 no 2079 0.383934066600518 2963 3286988
SGTC_1998 st075797 76.8 µM -0.29542525471784 0.397299904027121 no 2080 0.38383452164585 3045 24208315
SGTC_1014 4130-3005 69.3 µM -0.295658578220411 0.39724835967824 no 2081 0.383745416697837 2912 743608
SGTC_956 1185-0240 191 µM -0.296949349651165 0.396963243083768 no 2082 0.383252589445892 2938 1416193
SGTC_431 k089-0097 107 µM -0.297122311110783 0.396925042062872 no 2083 0.383186565656904 3044 5499420
SGTC_1270 0831-1170 17.3 µM -0.298089810819261 0.396711374115372 no 2084 0.382817309028931 2914 6764716
SGTC_2261 9010538 184.68 µM -0.298579155376302 0.3966033163809 no 2085 0.382630585964039 3044 6457250
SGTC_285 1486-1325 46 µM -0.30085675264279 0.396100478849636 no 2086 0.381761864820827 3049 22310230
SGTC_31 0508-1974 57.237 µM -0.303570705786669 0.395501530370465 no 2087 0.380727486163326 3056 6810525
SGTC_1254 0550-0035 264 µM -0.310100547114704 0.394061458371819 no 2088 0.378242248110952 3090 15121435
SGTC_2198 6589944 200 µM -0.312503668062509 0.393531844397061 no 2089 0.377328887921429 2998 5290268
SGTC_3271 9137798 49.47 µM -0.313782972228487 0.39324998404964 no 2090 0.376842938948419 3072 6498326
SGTC_89 0302-0250 142.109 µM -0.314540979596144 0.393083003849171 no 2091 0.376555098687371 2942 4203518 YLR208W SEC13
SGTC_3058 9093861 49.47 µM -0.31558275734695 0.392853544434895 no 2092 0.376159613495814 3134 17217477
SGTC_232 clozapine 119 µM -0.317776593300676 0.392370457341925 no 2093 0.375327203464419 2939 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1515 3460-0031 42.1 µM -0.318385108427285 0.392236490428723 no 2094 0.37509641639453 2992 2876596
SGTC_1748 st037455 53.6035 µM -0.318526619760943 0.39220533800165 no 2095 0.375042752833386 3146 580690
SGTC_2462 5162487 171.77 µM -0.31876983417147 0.392151798185671 no 2096 0.374950527346716 2936 2259986
SGTC_706 4262-0057 46.9 µM -0.31955624719257 0.391978695742835 no 2097 0.374652373073788 2978 883298
SGTC_2851 9015922 71.43 µM -0.320644585096515 0.391739169939128 no 2098 0.374239873060921 3149 2996893
SGTC_2738 aclarubicin 5.55 µM -0.320738286279048 0.391718549721402 no 2099 0.374204365318198 3030 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_127 0180-0333 59.125 µM -0.321101686489949 0.391638581447962 no 2100 0.374066666148029 2986 771601
SGTC_2375 9072683 200 µM -0.323409946305868 0.391130742850103 no 2101 0.373192398943071 3139 16798029
SGTC_1793 st048256 72.231 µM -0.324594133885467 0.390870282546393 no 2102 0.372744133759406 2957 672022
SGTC_447 ml7 120 µM -0.325261560462679 0.390723504620102 no 2103 0.372491560388387 3048 4216 Selective myosin light chain kinase inhibitor.
SGTC_1534 6-azauridine 81.6 µM -0.32561501564218 0.390645780399167 no 2104 0.372357825003343 2975 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2664 lyso-paf C-16 73.48 µM -0.33326187441601 0.388965323254233 no 2105 0.369468307899787 2987 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_133 0724-0033 378.92 µM -0.333358158099251 0.388944177324007 no 2106 0.369431971770237 2912 280309
SGTC_3328 9140624 29.0385 µM -0.335615795006011 0.388448447001946 no 2107 0.368580305764274 3148 4904392
SGTC_3198 9112019 49.47 µM -0.33925208531357 0.387650375145441 no 2108 0.367209917420488 2981 45595555
SGTC_766 1391-0721 126 µM -0.340807429707948 0.387309161865403 no 2109 0.366624278434284 3156 1020919 YIL115C NUP159
SGTC_1505 k297-0037 20.6 µM -0.341524573095773 0.387151863410028 no 2110 0.36635435451706 3029 4089396
SGTC_923 1900-2434 73.3 µM -0.342456614145289 0.386947456926922 no 2111 0.366003644573562 2964 5910570
SGTC_2094 5332512 191.667 µM -0.344849416424645 0.386422833704556 no 2112 0.365103790131814 3157 755774
SGTC_901 1112-0062 60.1 µM -0.345551733295855 0.386268889697913 no 2113 0.364839812488294 3020 1908457
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.345898046622311 0.386192986304555 no 2114 0.364709668356071 2999 442882
SGTC_353 1988-1175 58.3 µM -0.350453381412277 0.385194975041417 no 2115 0.362999235329239 2929 2788357
SGTC_2095 5432005 200 µM -0.351363414097106 0.384995690242661 no 2116 0.362657863052993 3021 783734
SGTC_3119 9125183 49.47 µM -0.351991985699703 0.384858059330359 no 2117 0.362422136420255 3056 22695334
SGTC_2889 9059656 51.95 µM -0.352628645632811 0.38471867219996 no 2118 0.362183429666038 3113 3949838
SGTC_94 0334-0113 514.748 µM -0.354622952938145 0.384282145081819 no 2119 0.361436039191256 3050 6795178
SGTC_1799 st045822 46.1415 µM -0.354864681220645 0.384229243962578 no 2120 0.3613454844836 3178 3674992
SGTC_2576 guaiol 23.12 µM -0.355067759774111 0.384184802825015 no 2121 0.361269414494668 3116 227829
SGTC_1690 st023502 41.2 µM -0.355928865277438 0.383996377849035 no 2122 0.360946919070527 3127 24207482
SGTC_2617 dihydrotanshinone i 20.83 µM -0.356257361588264 0.383924504321296 no 2123 0.360823918878366 3012 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2345 9052315 157.45 µM -0.356674434424143 0.383833256397438 no 2124 0.360667773362705 3118 6469265
SGTC_798 1287-0182 476 µM -0.364762737085761 0.382064962687721 no 2125 0.357644261426135 3223 1649755
SGTC_3049 9092223 49.47 µM -0.365649444779312 0.381871256278285 no 2126 0.357313337315217 3134 8623917
SGTC_2786 7743617 45.45 µM -0.366561227390981 0.3816721029466 no 2127 0.35697316698088 3068 583674
SGTC_1175 0741-0056 27.6 µM -0.372267500484824 0.38042644094188 no 2128 0.354846846692674 3244 765927
SGTC_708 3448-5400 146 µM -0.372339522984458 0.380410726540409 no 2129 0.354820037761647 3160 3462195
SGTC_633 0437-0093 97.7 µM -0.373096651666986 0.380245542553494 no 2130 0.354538255320178 3074 2831118
SGTC_2836 9010338 19.48 µM -0.374163958986894 0.38001272348949 no 2131 0.35414116813934 3053 2994051
SGTC_937 3122-0005 46.7 µM -0.374711747878173 0.379893247420381 no 2132 0.353937427139041 3211 759535
SGTC_156 3474-0145 5.642 µM -0.37611953497255 0.379586253152654 no 2133 0.353414016007382 3180 2265471
SGTC_3284 9108171 64.8615 µM -0.377423462443063 0.379301975108893 no 2134 0.352929466724575 3137 8687505
SGTC_276 colchicine 750 µM -0.37761429608757 0.379260375645798 no 2135 0.352858571484838 3205 2833 A microtubule depolymerizer.
SGTC_3072 9116419 49.47 µM -0.377638904771214 0.379255011347424 no 2136 0.352849429660943 3101 17170162
SGTC_1370 2001-0092 44.6 µM -0.379080918234166 0.378940716166406 no 2137 0.352313887865969 3289 790957
SGTC_1088 bifonazole 369 nM -0.381289959026369 0.378459398196678 no 2138 0.351494051736153 3149 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2517 totarol 10 µM -0.381758110407926 0.378357418978518 no 2139 0.35132039633664 3169 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1224 0823-0416 294 µM -0.382102582635362 0.378282386676874 no 2140 0.351192638120917 3206 3598164
SGTC_1633 st005664 67.9 µM -0.384946499447942 0.377663105596067 no 2141 0.350138526966724 3026 2063822
SGTC_998 3996-0085 177 µM -0.386303572074793 0.377367705036332 no 2142 0.349635927659901 3124 715391
SGTC_2764 methyldopa 94.69 µM -0.388894217602572 0.376803986007817 no 2143 0.348677199915101 3261 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1750 st081859 2.357 µM -0.391614638403431 0.376212310758308 no 2144 0.347671485126998 3149 5291695
SGTC_1879 gemcitabine 100 µM -0.393276195088226 0.375851075076396 no 2145 0.347057749125457 3102 60750 A nucleoside analog which inhibits DNA replication.
SGTC_791 1348-1292 225 µM -0.394222210996606 0.375645452244244 no 2146 0.34670849437385 3131 5437054
SGTC_1673 st016611 27.3 µM -0.397223102165088 0.374993422587022 no 2147 0.34560147379801 3262 5226799
SGTC_2001 4023502 57.655 µM -0.398440616544917 0.374728984402204 no 2148 0.345152711660648 3198 108941 YCR052W RSC6
SGTC_132 0417-1715 25.805 µM -0.399494867010089 0.374500053915306 no 2149 0.344764302573609 3271 6769098
SGTC_3296 9122258 64.045 µM -0.399675695450661 0.374460791461697 no 2150 0.344697697816251 3192 4730474
SGTC_373 0844-0104 25.9 µM -0.400639330873231 0.374251583662995 no 2151 0.344342842038401 3240 5375804
SGTC_2013 4024628 200 µM -0.403611978827256 0.373606447444231 no 2152 0.343249037786045 3253 5230760
SGTC_248 streptozotocin 5.23457 mM -0.404401238301918 0.373435218526855 no 2153 0.342958844876488 3198 5300 DNA alkylating agent.
SGTC_183 3914-0051 30.55 µM -0.405374828531283 0.373224033692228 no 2154 0.342601005298418 3248 1596232
SGTC_199 4063-0024 41.6 µM -0.405751399044199 0.373142360684905 no 2155 0.342462636017863 3226 306215
SGTC_2048 5246248 200 µM -0.407914710175005 0.372673278545629 no 2156 0.341668146339303 3246 677046
SGTC_2119 5528445 120.635 µM -0.411103072060395 0.371982273552255 no 2157 0.340498478725529 3274 791935
SGTC_2516 gossypol 71.55 µM -0.412192768467532 0.371746200998989 no 2158 0.340099068576463 3265 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_869 0564-0080 44.1 µM -0.413645210592992 0.371431617951378 no 2159 0.339566978925986 3161 6843321
SGTC_2070 5230947 200 µM -0.414174997179053 0.371316893342028 no 2160 0.339372975672843 3247 2835538
SGTC_43 0570-0105 72.5 µM -0.415894252120119 0.370944669674475 no 2161 0.338743692848314 3128 1114046 YDL195W SEC31
SGTC_160 3453-0671 289.699 µM -0.416151738525502 0.3708889335087 no 2162 0.338649486193726 3128 5322268
SGTC_2125 5246583 200 µM -0.418897019108043 0.370294851670332 no 2163 0.337645697846348 3309 835267
SGTC_466 geldanamycin 89.2 µM -0.420201321500253 0.370012707429265 no 2164 0.337169194728306 3159 5288382 HSP90 inhibitor.
SGTC_1074 carmofur 3.8 µM -0.421033942192388 0.369832633052916 no 2165 0.336865148415733 3141 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1280 0880-0253 10.1 µM -0.421837523124917 0.369658866289688 no 2166 0.336571807545814 3150 6836607
SGTC_787 4152-0075 138 µM -0.422551309975248 0.369504538965179 no 2167 0.336311328667783 3177 9566539
SGTC_2856 9022925 19.48 µM -0.423354074647051 0.369330998929612 no 2168 0.336018473387072 3274 4944862
SGTC_717 1532-0246 73.2 µM -0.424349528655619 0.369115840683472 no 2169 0.335655461644962 3195 9561992
SGTC_1840 st055363 71 µM -0.42496540768952 0.368982744609651 no 2170 0.335430946078775 3189 676033
SGTC_2124 5246320 200 µM -0.425871760148252 0.368786903625127 no 2171 0.335100646779577 3235 579342
SGTC_661 1304-0007 33.6 µM -0.427305778436717 0.368477116344759 no 2172 0.334578312282216 3190 3117130
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.427852180412107 0.368359101008682 no 2173 0.334379372040182 3181 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1933 st074711 15.9 µM -0.428226351267987 0.368278292396433 no 2174 0.334243166484639 3218 17250958
SGTC_2036 5160441 105 µM -0.430408517390381 0.367807132391854 no 2175 0.333449250318213 3195 134534 YIL048W NEO1
SGTC_1492 4158-0558 28.5 µM -0.432595219638315 0.367335192429646 no 2176 0.332654431459157 3241 3967268
SGTC_2062 5245942 200 µM -0.433597012365974 0.367119049695637 no 2177 0.332290552343878 3230 1376160
SGTC_318 1488-0629 67.2 µM -0.434503299548489 0.366923549125017 no 2178 0.331961499649117 3256 3662576
SGTC_104 0074-0074 590.992 µM -0.436983063529769 0.366388801082175 no 2179 0.331061815402308 3194 3943124
SGTC_1731 st035964 63 µM -0.438491347007927 0.366063674453371 no 2180 0.330515070698135 3174 6739575
SGTC_1203 3992-3522 103 µM -0.439733101688462 0.365796073105955 no 2181 0.330065212523579 3468 5322312
SGTC_2635 hydroquinidine 100 µM -0.440346574879103 0.365663892132001 no 2182 0.329843056378983 3160 442912 An experimental heart treatment.
SGTC_2464 5717415 7.67 µM -0.446287675015146 0.364384630209586 no 2183 0.327694729007069 3197 5285744
SGTC_837 0091-0265 12.5 µM -0.446840552532695 0.364265658905402 no 2184 0.327495094507499 3186 759367
SGTC_960 1222-0186 7.7 µM -0.447949261134104 0.364027120148987 no 2185 0.327094907674982 3303 3126296
SGTC_2996 9066192 71.4286 µM -0.448004769952099 0.364015178805633 no 2186 0.327074877063964 3222 6472854
SGTC_971 1315-0384 26.7 µM -0.452776800867996 0.362989089629763 no 2187 0.325354735205195 3204 6769120
SGTC_1669 st015249 58.4 µM -0.452832080530564 0.362977209058888 no 2188 0.325334830610161 3313 722793
SGTC_558 k064-0027 21.3 µM -0.453313144061947 0.362873825620806 no 2189 0.325161634695855 3280 5088526
SGTC_504 lovastatin 124 µM -0.454510073871289 0.362616641605916 no 2190 0.324730871456705 3240 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1420 4'-methoxyflavone 42 µM -0.455084446026305 0.362493248399546 no 2191 0.324524243736296 3283 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.455778809628937 0.362344096326282 no 2192 0.324274521757688 3342 1273210
SGTC_1681 tripelennamine 100 µM -0.456051145560282 0.362285603184453 no 2193 0.324176600018794 3286 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_188 3229-0966 278.469 µM -0.456438258791113 0.362202463357991 no 2194 0.32403742961845 3341 5722370
SGTC_1364 1653-0028 37.6 µM -0.458221726937294 0.361819514138314 no 2195 0.32339657594959 3246 5718652
SGTC_2291 7917025 104.35 µM -0.459321907820294 0.36158335044368 no 2196 0.32300150889019 3148 2964612
SGTC_1035 k081-0041 55.2 µM -0.459332466081141 0.361581084273542 no 2197 0.322997718460805 3349 731709
SGTC_2847 9005661 71.43 µM -0.46096120027851 0.361231559433779 no 2198 0.322413221108118 3272 2991449
SGTC_198 3454-2873 16.191 µM -0.462955421011138 0.36080375925258 no 2199 0.321698160547787 3233 710957
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.465482235477082 0.360261957190052 no 2200 0.320793077792471 3405 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2944 9067346 25.62 µM -0.466027494096328 0.360145079057328 no 2201 0.320597910349327 3342 6473075
SGTC_2991 9074669 71.4286 µM -0.466202257410696 0.360107620682328 no 2202 0.320535366837969 3365 17333109
SGTC_2100 5377183 190 µM -0.467190726515508 0.359895779733761 no 2203 0.320181713905784 3282 2844202
SGTC_657 3534-0529 86.7 µM -0.468893475718772 0.35953096080713 no 2204 0.319572890001449 3338 1049549
SGTC_2921 7974240 10.71 µM -0.46966213300128 0.359366315676599 no 2205 0.319298213012271 3325 2979074 YDR527W RBA50
SGTC_1068 loratadine 26.9 µM -0.46989960323594 0.359315455218963 no 2206 0.319213373895356 3250 3957 A H1 histamine antagonist.
SGTC_840 0245-0196 390 µM -0.470721563564938 0.359139430181792 no 2207 0.318919791728656 3372 3827528
SGTC_2673 kobusone 100 µM -0.470904850551808 0.35910018285127 no 2208 0.318854342017022 3297 6710676 An epoxy ketone and protein crosslinker.
SGTC_3148 9097893 49.47 µM -0.471015327219074 0.359076527147704 no 2209 0.318814894776092 3184 17174100
SGTC_2122 5258151 111.688 µM -0.47161276414308 0.358948610940361 no 2210 0.318601607130788 3231 2173356
SGTC_2050 5263056 171 µM -0.471883324128331 0.358890687002347 no 2211 0.318505035773727 3350 763468 YGL055W OLE1
SGTC_1722 st034304 3.6505 µM -0.473025402667005 0.358646216229287 no 2212 0.31809752799451 3230 4036148 YLR033W RSC58
SGTC_326 k292-0812 17.5 µM -0.473058453419718 0.358639142320878 no 2213 0.31808573835103 3300 3579357
SGTC_194 1486-1323 56.904 µM -0.475324997038305 0.358154145979773 no 2214 0.317277672365988 3267 5178754
SGTC_476 mead acid 10 µM -0.475655993479141 0.358083338293747 no 2215 0.317159738562427 3234 5312531 An omega 9 fatty acid.
SGTC_3149 9097855 49.47 µM -0.478137848250173 0.357552568637877 no 2216 0.316276047625079 3348 25236625 YMR079W SEC14
SGTC_2455 5377712 9.75 µM -0.478432194308273 0.357489638014423 no 2217 0.316171311999152 3290 2243908
SGTC_2749 bexarotene 57.39 µM -0.479743574311039 0.35720931459033 no 2218 0.31570486979968 3280 82146 An retinoic acid receptor inhibitor.
SGTC_207 4185-0010 4.486 µM -0.47983421379897 0.357189942142622 no 2219 0.315672641248499 3364 3761753
SGTC_2855 9016525 58.44 µM -0.480265837843924 0.357097695853536 no 2220 0.315519188546352 3276 43811474
SGTC_1986 st071812 45 µM -0.483410171652461 0.356425944127262 no 2221 0.314402263671996 3332 11838594
SGTC_2349 9023730 187.07 µM -0.484923676646776 0.356102759314764 no 2222 0.313865243307337 3391 4126287
SGTC_2235 salicylic acid 500 µM -0.487268289027032 0.355602308932064 no 2223 0.313034108495158 3333 338 A COX inhibitor and kinase inhibitor.
SGTC_849 0386-0493 241 µM -0.48898092000543 0.355236910254813 no 2224 0.312427602502 3255 726119
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.489578834773431 0.355109373365137 no 2225 0.312215978257252 3427 94937 An inhibitor of serotonin biosynthesis.
SGTC_862 0452-0056 10.2 µM -0.489866719099978 0.355047972622022 no 2226 0.312114107388301 3335 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_551 k048-0028 34.9 µM -0.490831236408139 0.354842285215894 no 2227 0.311772907613785 3385 6836383
SGTC_324 1315-0088 19.6 µM -0.491054884988312 0.354794597247684 no 2228 0.311693814572108 3327 6787421
SGTC_2702 st077768 96.8 µM -0.492077852024087 0.354576501829768 no 2229 0.311332154324448 3313 6484119
SGTC_1180 1193-0155 285 µM -0.492197810398252 0.35455092996094 no 2230 0.311289756101721 3354 2921347
SGTC_2941 9056145 11.23 µM -0.492303312668078 0.354528440282922 no 2231 0.311252469329694 3331 2119517
SGTC_2030 5175110 200 µM -0.492650944508317 0.354454339986076 no 2232 0.31112962246327 3383 2831986
SGTC_2922 7999257 32.47 µM -0.49407095697663 0.354151711065885 no 2233 0.310628034084651 3356 2988377
SGTC_1005 4092-0690 4.4 µM -0.496135228029351 0.353711943915953 no 2234 0.309899503040418 3271 1529343
SGTC_1168 k815-0004 80.5 µM -0.500470091643596 0.352789091158613 no 2235 0.308372055212837 3233 642433
SGTC_39 0986-0283 58.349 µM -0.502577200238019 0.352340819295496 no 2236 0.307630781235527 3445 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1562 morin hydrate 59.1 µM -0.507305775838869 0.351335596760259 no 2237 0.305970143286472 3420 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2301 7769476 200 µM -0.511711187433655 0.350400008566818 no 2238 0.304426577609471 3325 977820
SGTC_2935 9038016 29.96 µM -0.513536279866351 0.350012674515411 no 2239 0.303788119713557 3434 6463195
SGTC_2427 5545055 42.75 µM -0.515061142767723 0.349689176899802 no 2240 0.303255147336418 3317 5372858
SGTC_2903 5923464 63.88 µM -0.515598945985231 0.349575108684243 no 2241 0.303067273311657 3406 2876576
SGTC_2730 imipramine 71.33 µM -0.516749995849285 0.349331016329689 no 2242 0.302665345252918 3422 3696 A tricyclic antidepressant.
SGTC_299 1273-0059 1.44 µM -0.518565940381164 0.348946052704475 no 2243 0.302031732799824 3360 2848077
SGTC_1300 1094-0077 113 µM -0.5193134055874 0.348787642050562 no 2244 0.301771103259052 3331 5532636
SGTC_2041 5107442 45.335 µM -0.521654225572512 0.348291721589162 no 2245 0.300955550457721 3451 793005
SGTC_2170 morpholine 200 µM -0.522399299716386 0.348133926335984 no 2246 0.300696171742425 3401 121171 Reacts with secondary amines.
SGTC_778 3456-2434 196 µM -0.523443269930571 0.347912873716725 no 2247 0.300332909742681 3403 5539063
SGTC_2762 leflunomide 42.06 µM -0.52571474489855 0.347432085094742 no 2248 0.299543208730239 3371 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1101 ebselen 5.29 µM -0.527916872153827 0.346966209072033 no 2249 0.298778516852004 3459 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_532 1548-0774 215 µM -0.528332299372759 0.346878348329439 no 2250 0.298634358681003 3522 5932993
SGTC_1554 st069299 38.7 µM -0.528496574108001 0.346843607330152 no 2251 0.298577362127644 3386 24207999
SGTC_233 rapamycin 362 pM -0.530909580201469 0.346333450683646 no 2252 0.297740719335158 3422 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_643 k048-0106 28.4 µM -0.531554865506872 0.346197071944793 no 2253 0.297517165966834 3412 6763920
SGTC_645 0845-0943 5.41 µM -0.532435524885022 0.34601097992128 no 2254 0.297212193066891 3354 1885106
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.532626394648813 0.345970652156689 no 2255 0.297146113591865 3465 23847180
SGTC_1216 1165-0504 9.65 µM -0.533300223045961 0.345828296838963 no 2256 0.296912886648866 3440 6304004
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.536106795897102 0.345235605158731 no 2257 0.295942371799763 3393 16623 A steroid.
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.537872287240205 0.344862963215616 no 2258 0.295332610967222 3515 16725076
SGTC_2652 actinonin 100 µM -0.541253698279201 0.344149669625137 no 2259 0.294166364892977 3374 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_3103 9120822 49.47 µM -0.543295074727302 0.343719318427984 no 2260 0.293463327431884 3526 17141819
SGTC_2121 5257820 149.641 µM -0.543586157517148 0.343657970513343 no 2261 0.293363143747932 3468 791256
SGTC_2202 7226349 200 µM -0.544988709086677 0.343362429828718 no 2262 0.292880641581624 3332 844334
SGTC_2872 9044037 25.97 µM -0.545482712182738 0.343258358044372 no 2263 0.292710783673314 3404 6465195
SGTC_479 n-linoleoylglycine 10 µM -0.545855229432036 0.343179887580858 no 2264 0.292582727695695 3390 6433346 An anti-infammatory.
SGTC_2373 9071805 200 µM -0.548017908644464 0.342724454585414 no 2265 0.291839803040703 3460 10149009
SGTC_1041 0206-0046 107 µM -0.550503297795104 0.342201345138189 no 2266 0.290987107796781 3376 50494
SGTC_3261 9137475 49.47 µM -0.551255655135876 0.342043053215945 no 2267 0.290729216349386 3330 17027690
SGTC_1062 mesoridazine 14.2 µM -0.553103625025694 0.341654368196588 no 2268 0.290096227283123 3436 4078 A neuroleptic.
SGTC_1806 st050005 60.3 µM -0.55312568403582 0.341649729519798 no 2269 0.290088675265992 3376 5194765
SGTC_2300 7976697 71.57 µM -0.553804279897535 0.341507042741261 no 2270 0.289856399464668 3330 2236109
SGTC_565 1418-0001 44.5 µM -0.554346786995168 0.341392987321477 no 2271 0.289670768103398 3497 2862145
SGTC_475 α-linolenic acid 10 µM -0.555077531299552 0.341239380249342 no 2272 0.289420815260566 3559 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_718 1130-0073 349 µM -0.555871976602807 0.341072412666462 no 2273 0.289149188346074 3528 6740020
SGTC_1397 3532-0190 20.1 µM -0.556604369000324 0.340918514230607 no 2274 0.288898884032618 3353 5322280
SGTC_1960 st011366 51.8 µM -0.558442872804899 0.340532304027803 no 2275 0.28827100191005 3453 3972846
SGTC_2477 5967686 25.23 µM -0.559116091267813 0.340390924385388 no 2276 0.288041246780746 3376 776118
SGTC_2285 7945142 200 µM -0.559780908649439 0.340251331027715 no 2277 0.287814443614804 3456 2970608
SGTC_676 falcarinol 140 µM -0.560012796664153 0.340202646073216 no 2278 0.287735354616246 3527 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_702 1488-0190 94 µM -0.562614254911847 0.33965665191312 no 2279 0.286848791546347 3463 949357
SGTC_1079 idarubicin 2.36 µM -0.562809932445923 0.339615596689848 no 2280 0.286782158070903 3448 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_655 k060-0012 42 µM -0.564770242352901 0.339204407961639 no 2281 0.286115024967203 3387 5994525
SGTC_838 0109-0203 71.4 µM -0.567320795685747 0.338669698145648 no 2282 0.285248125404295 3460 759422
SGTC_55 0767-0285 6.563 µM -0.571158417775622 0.337865773912003 no 2283 0.283946131171319 3465 3116166
SGTC_1478 0453-0656 35.7 µM -0.574320276821922 0.337203966956122 no 2284 0.282875545165748 3502 5258496
SGTC_1499 4480-0877 67.3 µM -0.582258607851483 0.335544621721414 no 2285 0.280196250876369 3453 2861909
SGTC_1112 tnp00069 1.16933 µM -0.583417335774235 0.335302680493024 no 2286 0.279806195217801 3491 145826
SGTC_1319 1306-0155 43.7 µM -0.583801994031026 0.335222379329049 no 2287 0.279676768266723 3504 3122360
SGTC_91 0417-1751 58.384 µM -0.584376847748919 0.335102387041887 no 2288 0.279483399932669 3543 6795624
SGTC_2589 lobaric acid 100 µM -0.586093139471513 0.334744236458011 no 2289 0.278906463175428 3425 73157 A novel microtubule depolymerizer.
SGTC_1335 1486-0900 202 µM -0.587404697827619 0.334470645693381 no 2290 0.278465969729285 3508 X1335
SGTC_2799 7812892 81.82 µM -0.592181248868836 0.333475002035351 no 2291 0.27686461221218 3525 20205235
SGTC_1850 st056238 17 µM -0.592306448123391 0.333448920726906 no 2292 0.276822699399044 3508 5393177
SGTC_2853 9015042 58.44 µM -0.592648814942953 0.333377603529995 no 2293 0.276708101516661 3428 6457456
SGTC_768 0384-0033 77.3 µM -0.593551692568987 0.333189557239041 no 2294 0.276405999575429 3418 3965305 YMR134W ERG29
SGTC_500 h-89 112 µM -0.593864596586623 0.333124397124917 no 2295 0.276301339965461 3556 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2259 7964009 200 µM -0.595466971942715 0.332790792438973 no 2296 0.275765685068361 3529 313134
SGTC_2831 7999036 19.48 µM -0.596673557834997 0.332539676007771 no 2297 0.275362674969372 3540 2988270
SGTC_1283 0922-0125 16.4 µM -0.597045185372504 0.332462347466593 no 2298 0.275238606570444 3484 3360884
SGTC_1516 st013856 110 µM -0.597052951275038 0.332460731607718 no 2299 0.27523601420605 3496 5281404 A mutagen and neurotoxin.
SGTC_2204 7233102 200 µM -0.598462971217031 0.332167399019002 no 2300 0.27476552959541 3448 2172480
SGTC_938 3126-1755 342 µM -0.598590395501483 0.332140895452485 no 2301 0.274723031183356 3534 1777771
SGTC_310 1273-0058 1.06 µM -0.599228305865622 0.332008226149542 no 2302 0.274510324736972 3537 2734232
SGTC_3250 9135583 49.47 µM -0.600972903438508 0.331645501341048 no 2303 0.273929017044072 3528 7699353
SGTC_1200 1643-0193 18.4 µM -0.603172275804329 0.331188447749497 no 2304 0.273197044542499 3539 5403974
SGTC_3239 9133757 49.47 µM -0.604492889566858 0.330914130531777 no 2305 0.272757997570182 3509 17036923
SGTC_1198 1612-1005 86.7 µM -0.606200274950152 0.330559607843182 no 2306 0.272190885118664 3599 6998509
SGTC_2879 9041815 71.43 µM -0.61406306524251 0.328928938224993 no 2307 0.26958682694348 3499 4942971
SGTC_808 0711-0032 135 µM -0.615736063249434 0.328582392360938 no 2308 0.269034365764363 3532 4252555
SGTC_152 4469-0003 551.229 µM -0.615783336909593 0.328572602204896 no 2309 0.269018763208545 3556 697280
SGTC_2977 9011197 71.43 µM -0.620055111421353 0.327688423952766 no 2310 0.267610751982968 3580 2704722
SGTC_1782 st039423 80.636 µM -0.620757036274028 0.327543230709957 no 2311 0.267379747768049 3471 2068169
SGTC_2290 7904846 200 µM -0.621210971160053 0.327449348106335 no 2312 0.267230410893048 3539 2962154
SGTC_3080 9117754 49.47 µM -0.62231924228437 0.327220181833065 no 2313 0.26686598542772 3622 9550191
SGTC_2056 5235370 200 µM -0.622369209253613 0.327209851288121 no 2314 0.266849561036966 3513 5511916
SGTC_1427 4048-4900 550 nM -0.62294646841407 0.327090514011012 no 2315 0.266659850127676 3559 24132586
SGTC_2168 5727979 200 µM -0.624273276179119 0.326816288936327 no 2316 0.266224065588468 3505 695210
SGTC_1504 k297-0033 30 µM -0.625075773487997 0.326650473897609 no 2317 0.265960663736309 3426 4388117
SGTC_2064 5220758 200 µM -0.625102822468726 0.326644885530853 no 2318 0.26595178781202 3613 788518
SGTC_626 0214-0009 33 µM -0.627380973823697 0.326174355175044 no 2319 0.265204768183167 3592 3437874
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.630089066158235 0.325615384442341 no 2320 0.264318156455654 3551 17037758
SGTC_610 4215-0184 155 µM -0.633634924679018 0.324884085044199 no 2321 0.263159551484825 3585 5605015
SGTC_277 nystatin 15.5 µM -0.63555125851656 0.324489140014486 no 2322 0.262534473536352 3543 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_814 3342-0569 96 µM -0.635654396227049 0.324467889536209 no 2323 0.262500853201773 3617 4346283
SGTC_1394 3474-0001 65.7 µM -0.636720895079082 0.324248181797143 no 2324 0.262153330309504 3488 5017666 YIL048W NEO1
SGTC_68 0986-0284 82.829 µM -0.636766309413595 0.324238827419635 no 2325 0.262138537103041 3547 423278 YIL048W NEO1
SGTC_1602 st001878 87.6 µM -0.637655285729464 0.324055739738683 no 2326 0.261849049278056 3606 595405 YLR310C CDC25
SGTC_2518 prenyletin 46.28 µM -0.638677912471452 0.323845178925368 no 2327 0.261516242202255 3514 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2734 clemastine 41.6 µM -0.640680534861341 0.32343299842883 no 2328 0.260865131674631 3542 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_480 am 92016 50 µM -0.641472070365009 0.323270143983684 no 2329 0.260608010679307 3522 2129 K+ channel blocker.
SGTC_24 0417-1663 219 µM -0.642975515162394 0.32296091103961 no 2330 0.260119993798464 3578 4329390
SGTC_981 1488-1094 54.9 µM -0.643665879269107 0.32281895589511 no 2331 0.259896060139036 3577 3449522
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.64661153622609 0.322213549590422 no 2332 0.258941694921114 3656 688801
SGTC_2219 9098279 200 µM -0.650035034012406 0.321510527282122 no 2333 0.257834795917044 3584 902349
SGTC_1807 st050092 58.9 µM -0.652242301482937 0.321057598894711 no 2334 0.257122437515041 3550 5008496
SGTC_2797 7859098 81.82 µM -0.65295617779474 0.320911169328743 no 2335 0.256892265185929 3612 972681
SGTC_1853 st056710 91.2 µM -0.65300663481801 0.320900820690262 no 2336 0.25687600058445 3670 269167
SGTC_2491 paeonol 100 µM -0.655639663088487 0.320360984896417 no 2337 0.256027999591777 3557 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2402 5553605 200 µM -0.657057450321591 0.320070460794563 no 2338 0.25557198839943 3642 6758546
SGTC_1468 k284-1086 134 µM -0.65759917148998 0.319959483789884 no 2339 0.255397863539915 3625 15996457
SGTC_1999 st074831 12.5 µM -0.658712373770448 0.319731483733152 no 2340 0.25504024281213 3591 17112523
SGTC_1133 3473-0247 50 µM -0.659665491685738 0.31953632539976 no 2341 0.254734258128408 3572 711311
SGTC_2129 girgensonine 121.053 µM -0.660574125430377 0.319350322070395 no 2342 0.254442733509446 3643 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_78 0336-0123 156.75 µM -0.660824233740562 0.319299131222815 no 2343 0.254362519849238 3499 6765896
SGTC_632 0781-2353 4.65 µM -0.661958313921581 0.319067056914426 no 2344 0.253998968912311 3636 6811515 YHR007C ERG11
SGTC_651 3253-0966 34.4 µM -0.662007702150652 0.319056951885743 no 2345 0.253983142775005 3622 781462
SGTC_281 1672-3440 14.9 µM -0.663060236728738 0.318841631090594 no 2346 0.253645987955852 3615 6833000
SGTC_382 3229-0966 23.2 µM -0.66667125698746 0.318103376657715 no 2347 0.252491071180344 3642 5722370
SGTC_1646 st011709 75.6 µM -0.667793073197636 0.317874174004347 no 2348 0.252132844373757 3603 5757843
SGTC_2268 7933382 153.85 µM -0.669785998757392 0.317467163675811 no 2349 0.251497110128736 3661 935025 YOR257W CDC31
SGTC_2374 9071832 200 µM -0.672237747041687 0.316966751713301 no 2350 0.250716177020892 3599 17381698
SGTC_3283 9109332 35.8195 µM -0.672494695874703 0.316914326749922 no 2351 0.25063440785159 3528 17027281
SGTC_2893 9048488 25.97 µM -0.673635336492455 0.316681647594324 no 2352 0.250271590875836 3592 6467338
SGTC_175 3793-3120 23.7 µM -0.683371658961186 0.314698495051632 no 2353 0.247186011902211 3651 5322297
SGTC_1501 4491-0275 38.4 µM -0.687916248803069 0.313774647604245 no 2354 0.245752761784703 3645 5104718
SGTC_3066 9117245 49.47 µM -0.690920089080682 0.313164651444812 no 2355 0.244807880395767 3722 17176980
SGTC_1686 st019653 115.5 µM -0.69227616204983 0.312889438143569 no 2356 0.244381958612402 3663 97252
SGTC_3255 9139072 49.47 µM -0.695874476428951 0.312159670390911 no 2357 0.243253721405702 3684 17646060
SGTC_742 0kpi-0133 140 µM -0.696570283700201 0.312018639837523 no 2358 0.24303587911409 3676 2728852
SGTC_1874 staurosporine 7.6 µM -0.697224959518217 0.311885971217944 no 2359 0.242831010577419 3693 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2398 5228213 48.84 µM -0.697477565904791 0.31183478761108 no 2360 0.242751987133526 3677 80771 YMR134W ERG29
SGTC_2459 5811157 9.22 µM -0.69959044685962 0.311406813876658 no 2361 0.242091555131691 3645 2870684 YBR192W RIM2
SGTC_2005 4024620 188 µM -0.703915452421435 0.310531558991714 no 2362 0.240742713873782 3684 236743
SGTC_2108 5365811 200 µM -0.704818963611601 0.310348849843188 no 2363 0.240461452789618 3732 780283
SGTC_1130 3454-2858 15.9 µM -0.70576730967509 0.310157124463073 no 2364 0.24016642730971 3695 715628 YIL048W NEO1
SGTC_17 0960-0276 49.807 µM -0.710577888591676 0.309185374082715 no 2365 0.238672924552512 3684 6821114
SGTC_1345 1488-0192 31.4 µM -0.710961485341474 0.309107943783312 no 2366 0.238554051449859 3706 658348
SGTC_408 cantharidin 100 µM -0.715500157998528 0.30819244183706 no 2367 0.237150021628542 3687 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2221 6807166 181.081 µM -0.71767553870765 0.30775406496735 no 2368 0.236478684615664 3649 674925
SGTC_2059 5238311 157 µM -0.718143550801676 0.307659788262627 no 2369 0.236334389799276 3710 703021
SGTC_1317 1273-0028 910 nM -0.721579084970111 0.306968120815294 no 2370 0.235276650924764 3699 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1137 ixabepilone 100 µM -0.722446162267056 0.30679366271798 no 2371 0.235010107156231 3723 154225 A novel microtubule stabilizer.
SGTC_2444 5485484 36.41 µM -0.724918954326283 0.306296371250169 no 2372 0.23425087598654 3788 6790631
SGTC_1483 3453-0561 55.9 µM -0.725748003579917 0.306129724870229 no 2373 0.233996633955339 3708 4546991
SGTC_2330 7979373 200 µM -0.730081820798719 0.305259241997082 no 2374 0.232670086368926 3689 1863007
SGTC_1314 1222-0010 41.1 µM -0.73154688333367 0.304965220711113 no 2375 0.232222589373729 3746 3526027
SGTC_2810 7959871 45.46 µM -0.732693158732475 0.304735264109786 no 2376 0.231872798749046 3740 2974535
SGTC_660 4031-1742 102 µM -0.734202698615079 0.304432549960283 no 2377 0.231412604509263 3653 6738706
SGTC_2732 terfenadine 20 µM -0.735094232892965 0.304253829868704 no 2378 0.23114105318703 3724 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2037 5169046 200 µM -0.735827297148366 0.30410691225287 no 2379 0.230917903330763 3785 5718022
SGTC_515 4092-1064 102 µM -0.737833489936181 0.303705001391045 no 2380 0.230307819762331 3754 717353
SGTC_1854 st056233 32.9 µM -0.737844908935341 0.303702714443178 no 2381 0.230304349824472 3663 5393174
SGTC_584 0986-0246 15.4 µM -0.741662450268285 0.302938584991599 no 2382 0.229145937914611 3834 53315 YDR232W HEM1
SGTC_2919 7978188 46.38 µM -0.744343063259527 0.302402541031197 no 2383 0.228334477536859 3716 2980291
SGTC_873 0591-4978 488 µM -0.746645404545155 0.301942480195842 no 2384 0.227638816603639 3786 3305145
SGTC_1895 st058434 18.3 µM -0.749835956258983 0.301305454800091 no 2385 0.226676755126595 3744 5393175
SGTC_1183 1254-0324 198 µM -0.749879863702541 0.301296692465015 no 2386 0.226663531542794 3811 5799357
SGTC_151 3013-0144 2.285 µM -0.749977906802811 0.301277127028265 no 2387 0.226634005520658 3733 906558 YHR107C CDC12
SGTC_3339 9145883 14.936 µM -0.751206093399294 0.301032079162036 no 2388 0.226264316816004 3680 2030670
SGTC_547 1120-0019 610 nM -0.752817239122706 0.300710759571349 no 2389 0.22577987299066 3694 3676939
SGTC_3126 9127922 49.47 µM -0.753006024054002 0.300673119294339 no 2390 0.225723147031405 3760 45595682
SGTC_1258 0671-0043 57.1 µM -0.754050792417277 0.300464849971336 no 2391 0.225409361605909 3780 4298767
SGTC_2016 5121758 140 µM -0.756153976421384 0.300045788564039 no 2392 0.224778441493376 3744 2795203
SGTC_722 3534-0461 190 µM -0.757313482843683 0.299814868936729 no 2393 0.224431037562245 3765 658262
SGTC_1027 k015-0025 8.67 µM -0.757948049846999 0.299688526849468 no 2394 0.224241041726963 3753 3598955
SGTC_1638 st008370 60.6 µM -0.758040425005448 0.299670136996091 no 2395 0.224213391278995 3762 24207134
SGTC_2258 7960471 200 µM -0.760515039418671 0.299177686337741 no 2396 0.223473391496961 3763 2974708
SGTC_1416 3966-0321 25.3 µM -0.760517745972799 0.299177147931967 no 2397 0.223472582900128 3791 582530 YLR208W SEC13
SGTC_246 cycloheximide 667 µM -0.762031473899376 0.298876096013664 no 2398 0.223020609818744 3654 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_1727 st034309 9.9045 µM -0.763777913849745 0.298528933167921 no 2399 0.222499800330916 3860 870305
SGTC_3024 9090631 49.47 µM -0.763984290003712 0.298487921186691 no 2400 0.222438302322492 3713 25236383
SGTC_1450 4112-4260 37.6 µM -0.764195371294701 0.29844597683177 no 2401 0.222375412260391 3747 1633175
SGTC_3355 9151058 44.0485 µM -0.765542961968221 0.298178257831994 no 2402 0.221974147040441 3793 17015728
SGTC_2948 9070189 9.45 µM -0.766509169700731 0.297986373602092 no 2403 0.221686698935597 3681 6473636 YDL196W YDL196W
SGTC_2424 5537928 59.2 µM -0.766762288491372 0.297936114727116 no 2404 0.221611430926248 3848 5382802
SGTC_2544 sphondin 68.51 µM -0.767192100665893 0.297850780741023 no 2405 0.221483654410791 3759 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1010 4112-3296 15.2 µM -0.770090538798927 0.297275622291472 no 2406 0.220623093945818 3839 704384
SGTC_3000 9075062 71.4286 µM -0.771789872599755 0.296938647139129 no 2407 0.220119445453447 3768 17057871
SGTC_2352 9027995 87.8 µM -0.772532107465124 0.296791518018906 no 2408 0.219899669005618 3758 2997347
SGTC_1794 st048918 76.9 µM -0.77287026979369 0.296724497034352 no 2409 0.21979958059079 3696 672303
SGTC_1326 1431-2094 10.8 µM -0.77393414974675 0.296513690010437 no 2410 0.21948486674614 3779 616278
SGTC_385 1494-0393 12.4 µM -0.774320374317075 0.29643717688078 no 2411 0.21937067900521 3797 3090647
SGTC_2655 perillic acid 100 µM -0.774422153158412 0.296417015460793 no 2412 0.219340593657184 3823 5702197 An apoptosis inducer.
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.776527379979577 0.29600013109471 no 2413 0.218718830446387 3800 676296 Flavone; oxidizing agent.
SGTC_1215 3852-0577 11.2 µM -0.776711730736122 0.295963638134203 no 2414 0.218664432155934 3870 2884876
SGTC_178 4092-0806 87.505 µM -0.779946970626287 0.295323546111963 no 2415 0.217711044719912 3761 2169044
SGTC_446 go6976 132 µM -0.78098968681041 0.295117380604345 no 2416 0.217404280221808 3775 3501 A protein kinase C inhibitor.
SGTC_1688 st021091 57.6 µM -0.78428563462168 0.294466143133481 no 2417 0.216436263371597 3838 3656366
SGTC_1668 st014914 51.6 µM -0.78498037830612 0.294328955286959 no 2418 0.216232536555458 3819 2839556
SGTC_1291 0993-0025 5.79 µM -0.78650485718469 0.29402802692729 no 2419 0.215785887305563 3847 4353356
SGTC_339 3091-4833 71.4 µM -0.786816345068431 0.293966557493828 no 2420 0.215694691905714 3741 3240077
SGTC_2839 9003951 25.97 µM -0.788519166330149 0.293630625559287 no 2421 0.215196546061282 3834 2990634
SGTC_936 3005-4620 401 µM -0.791262562156192 0.293089783590339 no 2422 0.214395395140528 3815 777207
SGTC_763 3453-1109 128 µM -0.794324115290216 0.292486765166678 no 2423 0.21350338427903 3808 1560353
SGTC_2896 9052656 71.43 µM -0.795318999905012 0.292290932063328 no 2424 0.213213982036575 3762 6469436
SGTC_2533 agelasine 13.65 µM -0.79593882017749 0.292168957471835 no 2425 0.213033798075929 3857 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2951 9072950 58.06 µM -0.799658327527673 0.291437492672512 no 2426 0.211954391739193 3835 16488155
SGTC_211 3455-0679 143.504 µM -0.799834240200215 0.2914029194927 no 2427 0.211903420980965 3870 748649
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.800453021562053 0.291281321861375 no 2428 0.211724185846455 3833 6708739 YPR165W RHO1
SGTC_1907 st060210 83.7 µM -0.801404368582679 0.291094417476535 no 2429 0.21144879345388 3867 688793
SGTC_1766 st045414 44.774 µM -0.802344266500603 0.290909817440936 no 2430 0.21117692141386 3868 253960
SGTC_295 k015-0027 31 µM -0.802729397220355 0.290834191899388 no 2431 0.211065578852223 3819 3887424
SGTC_288 1315-0019 35.1 µM -0.804282004317394 0.290529410082658 no 2432 0.210617064123623 3910 6811474
SGTC_3128 9127691 49.47 µM -0.805830999393493 0.290225486348413 no 2433 0.210170150603918 3877 41316314
SGTC_130 0136-0219 337.655 µM -0.807417619768732 0.289914334764704 no 2434 0.209712959476854 3740 234244
SGTC_757 1066-0008 322 µM -0.809309132745646 0.289543595350444 no 2435 0.20916867717701 3889 6842497
SGTC_1847 st056231 15 µM -0.809480443860167 0.28951002910912 no 2436 0.209119423560761 3846 5393180
SGTC_1816 st051957 91.6 µM -0.810083482427815 0.289391885886845 no 2437 0.208946098429531 3834 674121
SGTC_649 1123-0311 367 µM -0.81049029224145 0.289312199265986 no 2438 0.208829221110149 3802 693629 YIL048W NEO1
SGTC_1432 4049-0298 68.4 µM -0.810622354843134 0.289286332828842 no 2439 0.208791287529411 3849 741646
SGTC_834 0312-0008 75.7 µM -0.810640239617464 0.28928282991167 no 2440 0.208786150629992 3837 6385573 YIL048W NEO1
SGTC_526 4469-0568 170 µM -0.811970936731223 0.289022255121717 no 2441 0.208404154188744 3814 2901964
SGTC_2611 pyromycin 23.93 µM -0.812264517098655 0.28896478159587 no 2442 0.208319933105016 3860 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_944 3370-0224 231 µM -0.813120753920704 0.288797188881482 no 2443 0.208074414238001 3899 4580514
SGTC_2443 5493264 126.67 µM -0.814731285101394 0.288482080867909 no 2444 0.20761307069541 3883 5340055
SGTC_853 0419-0306 21 µM -0.816140197882925 0.288206553389835 no 2445 0.207209977687635 3865 762713
SGTC_174 3553-0389 74.3 µM -0.81751325504938 0.287938157344531 no 2446 0.206817588751788 3867 738071
SGTC_954 1189-0853 2.85 µM -0.819738402075201 0.287503451229406 no 2447 0.206182626502879 3822 2828194
SGTC_2914 7968218 45.32 µM -0.82148742954675 0.287161978104975 no 2448 0.205684340692776 3850 2977111
SGTC_144 4161-2749 112.381 µM -0.822090327641795 0.287044315207631 no 2449 0.205512744986125 3783 797501 YMR168C CEP3
SGTC_208 k072-0098 12.366 µM -0.82323373523029 0.286821228041721 no 2450 0.205187544056663 3840 5948901
SGTC_1479 0549-0158 134 µM -0.823446918773252 0.286779643466937 no 2451 0.205126945545903 3898 5440202
SGTC_876 0720-0963 56.8 µM -0.827816261458642 0.285927969331655 no 2452 0.203887281967799 3900 765861
SGTC_1252 0493-0875 34.8 µM -0.828463295876064 0.2858019513895 no 2453 0.203704086593348 3856 3960963
SGTC_1284 0929-0043 16 µM -0.828669926138772 0.285761713159677 no 2454 0.203645603882034 3843 1239883
SGTC_1247 0448-0043 5.84 µM -0.828812112029496 0.285734026096481 no 2455 0.20360536672314 3925 3089013 YGL099W LSG1
SGTC_193 1273-0060 1.558 µM -0.829234094237963 0.285651863375524 no 2456 0.203485977974404 3726 2847393 YHR072W ERG7
SGTC_2602 kawain 100 µM -0.831186870670848 0.285271791370216 no 2457 0.202934035324672 3823 5369129
SGTC_618 k072-0232 33.2 µM -0.831513103825029 0.28520831958362 no 2458 0.202841914374686 3921 5872756 YGL099W LSG1
SGTC_811 0416-0114 265 µM -0.83207797832011 0.285098433754154 no 2459 0.202682465533558 3947 6612453
SGTC_146 3448-8650 53.125 µM -0.833820133184771 0.284759657088356 no 2460 0.202191174141985 3855 2891488 YIL048W NEO1
SGTC_976 1348-1067 47.6 µM -0.835189804394289 0.28449344797136 no 2461 0.201805424652208 3918 5310671 YGL099W LSG1
SGTC_2167 5876490 200 µM -0.83567114255497 0.284399923386314 no 2462 0.201669966942555 4041 686534
SGTC_1705 st027868 56.3335 µM -0.835781858223223 0.284378413276825 no 2463 0.201638817154457 3857 292948
SGTC_1610 st001799 48.1 µM -0.835790254056276 0.284376782145658 no 2464 0.20163645510934 3790 621897
SGTC_1614 st002383 48.6 µM -0.835935709449818 0.284348523976882 no 2465 0.201595535987911 3871 1947235
SGTC_888 0916-0002 6.97 µM -0.836368579137379 0.284264436687501 no 2466 0.201473791682211 3973 2802138 YIL048W NEO1
SGTC_2312 7706453 155.7 µM -0.838036948080006 0.283940458198234 no 2467 0.201004976348809 3909 976098
SGTC_2680 butyl paraben 22.24 µM -0.838213017184173 0.283906277868552 no 2468 0.200955538748307 3936 7184 An antifungal and steroid mimetic.
SGTC_3300 9124615 50.48 µM -0.838555748035317 0.283839749109403 no 2469 0.20085932591728 3945 24824903
SGTC_80 0159-0065 512.242 µM -0.841219166360209 0.283322997594579 no 2470 0.200112582553204 3788 1548079
SGTC_895 0964-0006 13.7 µM -0.841331871850151 0.283301140636026 no 2471 0.200081020127603 3860 6738897
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.841538899035566 0.283260993992419 no 2472 0.200023051333822 3948 5393153
SGTC_1746 st038117 42 µM -0.842137812783584 0.283144868203497 no 2473 0.199855408932345 3964 2898218
SGTC_433 pimozide 108 µM -0.844437676143684 0.282699150875783 no 2474 0.199212438149335 3819 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2600 tangeritin 87.95 µM -0.846927442531051 0.282217010416013 no 2475 0.198517782633255 3853 68077 A bioactive flavone.
SGTC_268 camptothecin 39.6153 µM -0.848620661346371 0.281889346749053 no 2476 0.198046203164466 3877 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2384 9036245 200 µM -0.849120772572009 0.281792602675047 no 2477 0.197907046380207 3873 6462766
SGTC_342 k048-0088 23.3 µM -0.849233624679204 0.281770774199223 no 2478 0.197875653262583 3895 6820570
SGTC_2033 5192550 145 µM -0.849821784583127 0.281657022267467 no 2479 0.197712088067313 3891 182073
SGTC_3238 9133470 49.47 µM -0.85006622222769 0.281609753790658 no 2480 0.197644134862377 3886 3534688
SGTC_2361 9034121 116 µM -0.850218091649534 0.28158038775236 no 2481 0.197601922559841 3913 6496917
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.851123237133945 0.281405396082638 no 2482 0.19735044925132 3899 6857784
SGTC_2806 7952793 58.44 µM -0.852881263980622 0.281065666990375 no 2483 0.196862576379525 3967 2972490
SGTC_3217 9129673 49.47 µM -0.855723369988852 0.280516864976032 no 2484 0.196075405179293 3905 17248312
SGTC_2721 ifenprodil 61.44 µM -0.85589347968799 0.280484033768025 no 2485 0.196028350940442 3886 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1116 jasmonic acid 1.58368 µM -0.856512226541463 0.280364631182723 no 2486 0.195857256441668 3976 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1810 st050138 53 µM -0.858673353755606 0.279947781190938 no 2487 0.195260377723017 3864 3444541
SGTC_1575 cyproterone acetate 48 µM -0.861112952030439 0.279477579583115 no 2488 0.19458791818157 3944 9880 An androgen receptor antagonist and liver toxin.
SGTC_625 k213-0058 121 µM -0.861181345441478 0.279464403149755 no 2489 0.194569086309618 3989 3655420
SGTC_3330 9141424 71.43 µM -0.863795865159518 0.278960925339865 no 2490 0.193850019846219 4000 27261020
SGTC_868 0527-0199 213 µM -0.864020804430304 0.278917629428196 no 2491 0.193788230984387 3878 2849450
SGTC_2195 6536160 144.242 µM -0.866384047051246 0.278462954386818 no 2492 0.193139794707627 3849 3834386
SGTC_1129 3453-1384 223 µM -0.866434017911027 0.278453344164929 no 2493 0.193126097812253 4063 1084452
SGTC_1786 berberine 21.6 µM -0.867451341558646 0.27825773116199 no 2494 0.192847380727524 3858 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2002 4023503 131 µM -0.86782252504221 0.278186375953399 no 2495 0.192745748463241 3920 4736863 YCR052W RSC6
SGTC_818 4072-2707 53.5 µM -0.868392831542568 0.278076759318998 no 2496 0.19258965890573 3842 882871
SGTC_927 2425-1185 123 µM -0.870321341700279 0.277706243244665 no 2497 0.192062409547734 3887 730375
SGTC_1228 0124-0032 52.5 µM -0.87161674660607 0.277457498318672 no 2498 0.191708745832099 4004 X1228
SGTC_2128 5255449 168.493 µM -0.872177751593646 0.277349807394025 no 2499 0.191555707434723 3937 736008
SGTC_1002 4049-0206 172 µM -0.873195520208462 0.277154487981125 no 2500 0.191278258096475 3947 4662749
SGTC_1052 3253-3998 198 µM -0.873345099779121 0.277125787921696 no 2501 0.191237502651659 3882 5450317
SGTC_154 3389-1638 511.116 µM -0.873668299432796 0.277063780079536 no 2502 0.191149459703408 3942 5238686
SGTC_1600 coumarin 106 71.1 µM -0.873793084025055 0.27703984120485 no 2503 0.191115473733331 4009 100336 A hepatotoxic, DNA x-linker.
SGTC_1805 st050013 60.3 µM -0.873886021200663 0.277022012647046 no 2504 0.191090164040996 3880 4037144
SGTC_393 acivicin 6.25 µM -0.873952064043045 0.277009343691907 no 2505 0.191072179763951 3786 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_546 peri-Naphthalide 147 µM -0.875150071208228 0.27677958001042 no 2506 0.19074612791082 3852 223824 A penicillin ester.
SGTC_311 1315-0136 58 µM -0.875505282047837 0.276711472698267 no 2507 0.190649518735202 4004 6759207
SGTC_3164 9100705 49.47 µM -0.876952897568807 0.276433995170906 no 2508 0.190256111321452 3970 17174235
SGTC_2467 5474540 200 µM -0.879660729388525 0.275915327244411 no 2509 0.18952156467983 3896 5413519
SGTC_2009 4012297 12.05 µM -0.879975281086854 0.275855107876447 no 2510 0.189436350312527 3963 45595307
SGTC_2414 st077232 92.9 µM -0.880595833341016 0.275736325153483 no 2511 0.189268307304609 3918 729801
SGTC_600 1495-0418 41.6 µM -0.883273989506225 0.275223975680076 no 2512 0.188544126823175 3922 5377768
SGTC_2074 5212007 75.395 µM -0.88561044463071 0.274777379064584 no 2513 0.187913740681288 3792 758611
SGTC_608 k048-0125 159 µM -0.885967205608489 0.274709218220108 no 2514 0.187817599613229 3990 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2486 5283202 22.39 µM -0.886164265446637 0.274671572596099 no 2515 0.187764508335573 4010 1377751
SGTC_997 3996-0078 137 µM -0.887593522031248 0.274398608572925 no 2516 0.187379719740518 3994 735687
SGTC_1730 st033808 45.1 µM -0.888178909398975 0.274286848072394 no 2517 0.187222260868693 3911 1045166
SGTC_828 2074-0507 139 µM -0.890071466395294 0.273925680309796 no 2518 0.186713756535251 4048 X828
SGTC_343 4130-2827 29.8 µM -0.890693722731595 0.273806982854918 no 2519 0.186546751659987 3993 1118244
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.891181973117412 0.27371386529014 no 2520 0.186415776891161 4003 521171
SGTC_2760 etidronate 98.04 µM -0.891297869617564 0.273691764177983 no 2521 0.186384695641868 3928 3305 A chelator and antioxidant.
SGTC_2460 5552655 174.22 µM -0.893016905335461 0.273364052959341 no 2522 0.185924059789333 3990 5401989
SGTC_2171 5739187 198.077 µM -0.893316470072814 0.273306964827506 no 2523 0.185843860179843 3896 2262761
SGTC_1834 st055981 52.8 µM -0.898086139479652 0.272398803936292 no 2524 0.184569813927335 4007 471719 YDL150W RPC53
SGTC_1626 st003712 1.76 µM -0.898626915419334 0.272295933084829 no 2525 0.184425708628718 3993 24207035
SGTC_518 1021-0119 62.6 µM -0.900463723419443 0.271946664537287 no 2526 0.183936761134119 3950 1097762
SGTC_1162 k048-0130 20.1 µM -0.90276425228065 0.271509534147508 no 2527 0.183325513696262 3939 6797406
SGTC_85 0868-0259 160.055 µM -0.902846671039202 0.271493880008055 no 2528 0.183303638668983 3917 83173
SGTC_338 4055-0136 114 µM -0.90320351241343 0.271426108821016 no 2529 0.183208947034353 3921 2900563
SGTC_280 3448-3607 3.04 µM -0.904731613003887 0.271135987859554 no 2530 0.182803794521647 3955 626179
SGTC_872 0588-0139 234 µM -0.904946441375864 0.271095213538943 no 2531 0.182746880936163 3940 2047100
SGTC_1070 indatraline 8.81 µM -0.90728750930208 0.270651078320385 no 2532 0.182127388852498 3965 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_292 k038-0015 474 µM -0.907576856070453 0.270596210200317 no 2533 0.182050913328456 3974 46368540
SGTC_424 splitomicin 100 mM -0.909045617883062 0.27031777820016 no 2534 0.181663023318498 4074 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2823 7987624 58.44 µM -0.911805347932529 0.269795006064159 no 2535 0.180935597316584 3986 2239440
SGTC_2325 6158266 200 µM -0.914472385603555 0.269290274000926 no 2536 0.18023434078465 4020 3623240
SGTC_1306 1185-0270 9.02 µM -0.914760697141359 0.269235739939225 no 2537 0.180158635998678 4019 1548076
SGTC_2406 ethylparaben 405.7 µM -0.914782261090572 0.269231661345807 no 2538 0.180152974543602 4037 8434 A possible steroid mimic.
SGTC_3331 9141060 1.957 µM -0.916250227011386 0.26895408397066 no 2539 0.179767833563284 3947 4906567 YPR165W RHO1
SGTC_262 fenpropimorph 62.5 µM -0.917861303893434 0.268649611225762 no 2540 0.179345741303025 3956 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_402 epigallocatechin gallate 10 µM -0.920199503357164 0.268208030007448 no 2541 0.178734256903965 3934 65064 An antioxidant.
SGTC_229 benomyl 22.8748 µM -0.922131688369817 0.267843402547267 no 2542 0.178229944871687 4011 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2017 5132927 60.65 µM -0.924921954037292 0.267317285583794 no 2543 0.177503252953772 4020 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1058 3448-5425 97.3 µM -0.925537198248667 0.267201348759393 no 2544 0.177343271825353 3871 7279705
SGTC_1988 st071872 53.4 µM -0.926588990642422 0.267003207445659 no 2545 0.177069986591536 4032 16414116
SGTC_2695 st077686 51.995 µM -0.927304510469011 0.26686845707177 no 2546 0.176884226570101 4041 2876092
SGTC_1414 3917-0015 5.4 µM -0.928415354432913 0.266659325322169 no 2547 0.176596078417747 3953 6618702
SGTC_257 daunorubicin 18.5 µM -0.929864258482456 0.26638667365045 no 2548 0.176220685301602 4031 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_835 0312-0010 67.2 µM -0.93015072287761 0.266332784097555 no 2549 0.176146525759024 3959 1626196
SGTC_147 4466-0538 29.23 µM -0.932853073337619 0.265824690791279 no 2550 0.175447917085773 4087 6742687 YHR072W ERG7
SGTC_2519 cryptotanshinone 88.04 µM -0.93546302754096 0.265334436536595 no 2551 0.174774864305054 3999 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_390 dec-rvkr-cmk 16.7 µM -0.935640777121034 0.265301064724094 no 2552 0.174729086082321 4043 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1836 st055642 81 µM -0.936183407670659 0.265199201069516 no 2553 0.174589382285558 4028 8571
SGTC_383 2324-0395 7.37 µM -0.936634829863358 0.265114474359735 no 2554 0.174473214743841 4021 3146421
SGTC_686 1319-0111 510 µM -0.939897211525143 0.264502572148372 no 2555 0.173635143905395 4047 4562600
SGTC_3020 9089140 49.47 µM -0.943075588154899 0.26390711808418 no 2556 0.172821120637627 4065 17217859
SGTC_253 dyclonine 31.25 µM -0.94312304347148 0.263898232731769 no 2557 0.172808985176093 4117 3180 An oral anasthetic.
SGTC_221 trifluoperazine 10.304 µM -0.947439808421774 0.263090616516721 no 2558 0.171707357089096 3995 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2969 9091408 28.7 µM -0.947940270786167 0.26299706762891 no 2559 0.171579931107431 3981 4286311
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.949528595161829 0.262700282871603 no 2560 0.17117591779383 3986 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1365 1672-3266 55.4 µM -0.951337151401013 0.262362555655964 no 2561 0.17071662666419 4074 6415873
SGTC_2546 rhodinyl acetate 100 µM -0.951798512026578 0.262276437438656 no 2562 0.170599588414476 3965 6708682
SGTC_2654 protoveratrine a 100 µM -0.952700608021212 0.262108092788334 no 2563 0.17037089260218 4021 5702278 A heart drug and vasodilator.
SGTC_2396 5342950 42.78 µM -0.953353851102733 0.26198622240473 no 2564 0.170205407639871 4032 1886677
SGTC_1136 pergolide 1.05886 µM -0.953741715405897 0.261913875384005 no 2565 0.170107199380145 4014 47811 A dopamine receptor agonist.
SGTC_2389 9091542 195.52 µM -0.954555399567867 0.261762134917214 no 2566 0.169901290444156 4024 3626624 YOL127W RPL25
SGTC_2057 5236571 38.335 µM -0.959030451925473 0.260928408453069 no 2567 0.168771702294961 4032 54684039 YBR257W POP4
SGTC_2401 5128683 200 µM -0.962265383541354 0.26032657474209 no 2568 0.167958156442001 4029 708373
SGTC_969 1313-0238 134 µM -0.962950788730132 0.260199152346675 no 2569 0.167786109994932 4071 5212874
SGTC_3007 9078383 71.4286 µM -0.965863718039656 0.259657973935999 no 2570 0.167056189763392 4039 6496995
SGTC_973 1325-0077 65.9 µM -0.966545634639507 0.259531368079813 no 2571 0.166885611691774 4058 2835149
SGTC_627 1391-0720 175 µM -0.966796200924367 0.259484855504863 no 2572 0.166822962008195 4026 997839
SGTC_631 k072-0230 41.5 µM -0.967910583975213 0.259278044940611 no 2573 0.166544513992527 4077 5773147
SGTC_679 0422-0091 41.4 µM -0.96831804873546 0.259202447674786 no 2574 0.166442776768646 4036 627384 YHR062C RPP1
SGTC_578 3460-0051 92 µM -0.97034593019889 0.258826382709 no 2575 0.165937045157121 4138 2876744
SGTC_1281 0884-0031 11.8 µM -0.972342896032768 0.258456327059906 no 2576 0.165439995120911 4068 1548255
SGTC_3205 9113483 49.47 µM -0.974707325657419 0.258018531707639 no 2577 0.164852729054299 4122 17018033
SGTC_3222 9128301 49.47 µM -0.974779670608721 0.258005142458001 no 2578 0.164834781664446 4080 4911358
SGTC_3212 9128307 49.47 µM -0.974959862017265 0.257971795080451 no 2579 0.164790085146388 4018 27243542
SGTC_2237 6667747 47.222 µM -0.975750305909383 0.257825536885843 no 2580 0.16459410813333 4057 729940 YDL015C TSC13
SGTC_729 4092-0585 94.1 µM -0.976535320216695 0.257680325945836 no 2581 0.164399626833553 4080 2169061
SGTC_501 nsc-95397 161 µM -0.977354158804391 0.257528903491016 no 2582 0.164196924628196 4120 262093
SGTC_1480 1070-0044 41.2 µM -0.977553840938338 0.257491984593126 no 2583 0.164147518222896 4074 3124987
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.977661065344497 0.257472161185462 no 2584 0.164120992174921 4100 23665772 A membrane-active detergent.
SGTC_1826 st055655 41.6 µM -0.978030922220442 0.257403788960345 no 2585 0.164029515302327 4090 676168
SGTC_1693 xanthone 101.9 µM -0.978075666278869 0.257395518154994 no 2586 0.164018450976901 4106 7020 An insecticide.
SGTC_2360 9040895 200 µM -0.978643169177602 0.257290628925621 no 2587 0.163878160690765 4092 4914414
SGTC_1667 st014849 34.6 µM -0.979043217939564 0.257216702908872 no 2588 0.163779312928437 4107 5348460
SGTC_1997 st073024 93.8 µM -0.98007268387629 0.257026516092847 no 2589 0.163525120896115 4070 686268
SGTC_3307 9126885 69.2785 µM -0.980107488430984 0.257020087467102 no 2590 0.163516531560075 4049 24824909
SGTC_3245 9134821 49.47 µM -0.981371506382996 0.256786671887488 no 2591 0.163204786025564 4063 17014901
SGTC_2568 diosmetin 100 µM -0.983250854584299 0.256439832532624 no 2592 0.162741995682739 4132 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1105 epirubicin 18.1 µM -0.9837736440942 0.256343393571425 no 2593 0.162613410419629 4100 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2207 7258803 200 µM -0.984007209679277 0.25630031384645 no 2594 0.162555984015683 4033 3666799
SGTC_415 dibenzyl ketone 100 µM -0.985270188302589 0.256067430655811 no 2595 0.162245686061665 4065 7593
SGTC_2488 5268135 45.7 µM -0.986243015418863 0.255888124370252 no 2596 0.162006937772888 4128 1270356 YLR208W SEC13
SGTC_789 1309-1135 70.6 µM -0.988612942919073 0.255451586420322 no 2597 0.161426275619021 4058 3092424
SGTC_3082 9117008 49.47 µM -0.988913383263167 0.25539627345631 no 2598 0.161352760992811 4139 41448529
SGTC_2123 5259487 200 µM -0.989297099204964 0.255325638032111 no 2599 0.16125890145168 4091 2173474
SGTC_2314 7727897 200 µM -0.991137255683577 0.254987039222951 no 2600 0.160809281657187 4092 900724
SGTC_1964 st076914 61 µM -0.993973073363113 0.254465693710217 no 2601 0.160117988363279 4116 24208661
SGTC_33 0986-0033 35.816 µM -0.994113189936879 0.254439948733301 no 2602 0.160083882294488 4032 2848082
SGTC_2118 5526350 200 µM -0.994162533893528 0.254430882614611 no 2603 0.160071872509635 4116 743594
SGTC_1473 k844-0725 134 µM -0.998041907486757 0.25371864340949 no 2604 0.159129518868424 4150 54682906
SGTC_605 1315-0399 119 µM -0.998861764309382 0.253568254734539 no 2605 0.15893083039243 4168 24020461
SGTC_519 k048-0011 62.8 µM -0.999537562703838 0.253444326326136 no 2606 0.158767176091561 4128 6836379
SGTC_3178 9107506 49.47 µM -1.00036064526123 0.25329343184155 no 2607 0.158568004072263 4111 8897194
SGTC_1567 st069303 68.4 µM -1.00127293121478 0.253126239037063 no 2608 0.158347437882202 4159 5581319
SGTC_2320 7373003 200 µM -1.00208292375346 0.252977842004589 no 2609 0.158151772264963 4175 5415828
SGTC_650 1328-0195 38 µM -1.00601780594482 0.25225759239311 no 2610 0.157203502403066 4089 2780821
SGTC_3207 9114163 49.47 µM -1.0062084988801 0.252222715023375 no 2611 0.157157642365581 4151 849233
SGTC_961 1252-1571 372 µM -1.00635138011699 0.252196583987551 no 2612 0.15712328640315 4115 6813498
SGTC_736 0958-0254 92.6 µM -1.00649529466456 0.252170265416586 no 2613 0.157088686973302 4196 6812352
SGTC_3274 9138298 49.47 µM -1.00675635809507 0.252122526779882 no 2614 0.157025935811272 4054 17015756
SGTC_1578 josamycin 24.2 µM -1.00717079720787 0.252046751318455 no 2615 0.156926351990016 4105 5282165 A P450 substrate.
SGTC_3353 9151644 39.2805 µM -1.00722361333047 0.25203709535656 no 2616 0.156913664012944 4137 4909158
SGTC_493 zm226600 134 µM -1.00809240170128 0.251878289534207 no 2617 0.156705052506584 4144 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1 0258-0098 57.368 µM -1.01066530688154 0.25140829820759 no 2618 0.156088323574023 4052 6790032 YDR047W HEM12
SGTC_1825 st052143 62.6 µM -1.01183056406049 0.251195593852527 no 2619 0.155809536763239 4142 674173
SGTC_1745 st081495 74 µM -1.01257692817135 0.251059403649844 no 2620 0.155631142364769 3996 13842402 YBL026W LSM2
SGTC_770 0389-1121 67.2 µM -1.01344777746372 0.250900547840659 no 2621 0.155423164139558 4202 6753108
SGTC_3 0833-0587 95.581 µM -1.01560600634034 0.250507084351792 no 2622 0.154908521752666 4007 5382644
SGTC_2493 resveratrol 26.09 µM -1.0163501378903 0.250371498676355 no 2623 0.154731340438922 4012 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_809 3998-0021 90 µM -1.01665743308588 0.250315518816404 no 2624 0.1546582110496 4055 715485
SGTC_2867 9039098 71.43 µM -1.0169299965837 0.25026587157156 no 2625 0.154593366144446 4059 6463460
SGTC_825 1988-2224 89.6 µM -1.01931575705017 0.249831529979991 no 2626 0.154026542861031 4094 1180859
SGTC_3247 9135149 49.47 µM -1.02006938357711 0.249694411099027 no 2627 0.153847777891857 4111 8934436 YOR116C RPO31
SGTC_569 4130-2812 160 µM -1.02114829192212 0.24949817827576 no 2628 0.153592093130118 3915 743552
SGTC_2101 5377231 179.231 µM -1.0214001957965 0.249452373574797 no 2629 0.153532436309248 4159 2844213
SGTC_2625 euphol 100 µM -1.02175878816274 0.249387176983274 no 2630 0.153447539593306 4149 6708538 A triterpene alcohol.
SGTC_1597 7-benzyloxygramine 47.5 µM -1.02200916624643 0.249341660476462 no 2631 0.153388281039022 4049 260807
SGTC_2327 6189656 200 µM -1.02206594224792 0.249331339719091 no 2632 0.153374845614859 4192 5349088
SGTC_2331 7980721 200 µM -1.0238098144348 0.249014448792711 no 2633 0.152962556913401 4089 2981221
SGTC_289 k017-0060 526 µM -1.02500643421346 0.248797126880524 no 2634 0.152680075861048 4094 5512909
SGTC_3327 9140648 26.9345 µM -1.0250288989145 0.248793047960812 no 2635 0.152674776023903 4152 8029710
SGTC_40 0327-0103 19.753 µM -1.02557192779108 0.248694460945431 no 2636 0.152546702629054 3979 409036
SGTC_783 0848-0141 92.7 µM -1.02672976999862 0.248484323922997 no 2637 0.152273863575655 4045 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2485 5633444 17.78 µM -1.026985120009 0.248437993134065 no 2638 0.152213735399403 4129 5724239
SGTC_968 1309-0633 340 µM -1.028368221085 0.248187122848163 no 2639 0.151888325630592 4171 3761976
SGTC_1379 2144-0755 36.5 µM -1.02867064000831 0.24813228736287 no 2640 0.151817235495734 4175 5392327
SGTC_2448 5185112 27.17 µM -1.0290223006516 0.248068531351874 no 2641 0.15173459783098 4154 5718189
SGTC_2241 6772625 37.8075 µM -1.03200493506904 0.24752813185704 no 2642 0.15103490281186 3976 2285411
SGTC_3105 9121040 49.47 µM -1.03483385796484 0.247016163871081 no 2643 0.150373253959367 3992 41448907
SGTC_2789 5281112 71.43 µM -1.03573630205478 0.246852962158334 no 2644 0.150162590767958 4147 765948
SGTC_258 haloperidol 50.781 µM -1.03856432696067 0.246341904518452 no 2645 0.149503701863395 4126 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_622 1348-1566 26.3 µM -1.03888913321839 0.246283244506111 no 2646 0.149428150424683 4154 7340407
SGTC_2920 7982904 15.77 µM -1.03928413995874 0.246211916378613 no 2647 0.149336304377325 4145 6456808
SGTC_3308 9128332 17.569 µM -1.0411597429024 0.245873381620966 no 2648 0.148900707992478 4145 17332805 YDL196W YDL196W
SGTC_1413 3910-0535 34.4 µM -1.04239811002514 0.24565000099882 no 2649 0.148613571191476 4144 2876951
SGTC_865 0488-0499 301 µM -1.04282890073369 0.245572319152537 no 2650 0.148513771770262 4106 9634651
SGTC_3051 9093778 49.47 µM -1.04303368572758 0.245535396158387 no 2651 0.148466345834636 4174 17217378
SGTC_2843 9000894 45.46 µM -1.04368941439417 0.245417187514525 no 2652 0.148314554482932 4060 2242070
SGTC_3110 9122132 49.47 µM -1.0448442275946 0.245209082945706 no 2653 0.148047485028441 4235 918317
SGTC_3183 9108214 49.47 µM -1.04503863522945 0.245174058806139 no 2654 0.148002556753203 4064 4974831
SGTC_730 1436-0052 41.2 µM -1.04595760010415 0.245008536119936 no 2655 0.147790304336031 4177 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_920 mycophenolic acid 780.421 nM -1.04677780651248 0.24486085246195 no 2656 0.14760103429 4148 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_848 0368-0089 85.6 µM -1.04724368287598 0.244776989641603 no 2657 0.147493601439869 4140 762535
SGTC_3157 9099274 49.47 µM -1.0482622778059 0.244593685330523 no 2658 0.147258892133548 4183 17217662
SGTC_290 2043-6722 48.1 µM -1.04876317407828 0.244503572161302 no 2659 0.147143565195074 4169 773758 YLR208W SEC13
SGTC_756 0508-1999 28.3 µM -1.04892211386332 0.244474982020046 no 2660 0.147106983373413 4147 6753853
SGTC_826 1683-5028 118 µM -1.05061791783481 0.244170052396256 no 2661 0.146717054181769 4197 722377
SGTC_145 3737-0113 38.366 µM -1.05068934917402 0.244157212530265 no 2662 0.146700644662075 4110 6849351
SGTC_93 0109-0045 59.227 µM -1.05082446199282 0.2441329268402 no 2663 0.146669609322116 4245 88733
SGTC_870 0573-2213 57.6 µM -1.05189999943263 0.24393965213039 no 2664 0.146422716095707 4138 3916321
SGTC_2663 amphotericin b 100 µM -1.0526027159727 0.243813418159746 no 2665 0.146261555943477 4148 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2891 9063876 19.48 µM -1.05294025406545 0.243752796328295 no 2666 0.146184187736098 4138 6472478
SGTC_561 1550-0330 72.9 µM -1.05341307934547 0.243667890605912 no 2667 0.14607585614021 4084 6812934
SGTC_2181 6316240 54.2555 µM -1.05356355313904 0.243640873221873 no 2668 0.146041391578802 4171 12779990
SGTC_3278 9139605 49.47 µM -1.05358915424685 0.243636276735564 no 2669 0.146035528437463 4164 7958859
SGTC_2525 harmine 47.85 µM -1.05418273405016 0.243529717077652 no 2670 0.145899631695921 4135 5280953 A monoamine oxidase inhibitor
SGTC_2523 spermine 47.74 µM -1.05784755111265 0.24287236568904 no 2671 0.145062475021296 4178 1103 A DNA binding polyamine.
SGTC_1353 1498-1206 8.11 µM -1.05853333560447 0.242749464534727 no 2672 0.144906180624394 4192 6756808
SGTC_1829 berberine 14.4 µM -1.05962303578995 0.242554245901412 no 2673 0.144658064706133 4145 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_384 k007-0144 5.16 µM -1.05988704738827 0.242506961301624 no 2674 0.144597994491118 4087 6824886
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.06121614628843 0.242268994923839 no 2675 0.144295841614239 4101 279621
SGTC_2451 5856223 45.7 µM -1.06227127927031 0.242080170486981 no 2676 0.144056274476051 4127 2179896
SGTC_525 k781-2675 26.7 µM -1.06287404839834 0.241972335986146 no 2677 0.143919536653693 4109 3651118 YDL195W SEC31
SGTC_2742 clothiapine 36.27 µM -1.06706374318283 0.241223526262519 no 2678 0.14297152636345 4150 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2481 5478948 45.16 µM -1.06753249449554 0.241139826362084 no 2679 0.142865724174517 4200 77792
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.06816918064803 0.241026165426506 no 2680 0.14272210206634 4167 688669
SGTC_538 2922-0838 53.3 µM -1.06932657375614 0.24081962274757 no 2681 0.142461270229411 4191 777039
SGTC_2532 xanthone 78.9 µM -1.07312441406113 0.240142555811765 no 2682 0.141607649171333 4169 7020 An insecticide.
SGTC_297 0986-0032 24 µM -1.0731846677213 0.240131822347997 no 2683 0.141594134248733 4099 2847425
SGTC_2981 9013952 38.96 µM -1.07558273923034 0.239704847181978 no 2684 0.141056955186556 4135 2996344
SGTC_1484 3473-2379 286 µM -1.0771033891617 0.23943431119127 no 2685 0.140717039571764 4289 671917
SGTC_3335 9143315 29.6265 µM -1.07783575483463 0.239304076896279 no 2686 0.140553530074889 4177 4899691
SGTC_2686 alizarin 95.37 µM -1.0789872238307 0.239099393044901 no 2687 0.140296711577459 4164 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1106 tegaserod maleate 11.7 µM -1.08020771565837 0.238882544280695 no 2688 0.140024846658175 4193 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_593 1203-0218 61.7 µM -1.08282599871429 0.238417708476291 no 2689 0.139442831659195 4201 3666956
SGTC_582 0987-0078 156 µM -1.08289442709597 0.238405566716558 no 2690 0.139427642894012 4212 1625765
SGTC_3354 9151612 71.43 µM -1.08527639051346 0.23798312822656 no 2691 0.138899629678204 4192 27261949
SGTC_1868 st057644 42.7 µM -1.08813090289032 0.237477424714543 no 2692 0.138268661499294 4197 688665
SGTC_563 tetrahydrosecaminediol 614 µM -1.08818841801828 0.237467241438776 no 2693 0.138255968333126 4237 334274 A psychoactive constituent of the cannabis plant.
SGTC_1797 st048695 56.8 µM -1.08851429982827 0.23740954733149 no 2694 0.138184063614013 4148 592262 YIL048W NEO1
SGTC_1946 st076057 65.1 µM -1.08924192810616 0.2372807558191 no 2695 0.138023606932688 4117 953009
SGTC_2727 riluzole 51.77 µM -1.08949998126754 0.237235089165126 no 2696 0.137966731553493 4202 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.09091990340727 0.236983897507509 no 2697 0.137654064173624 4144 6708514
SGTC_492 tmb-8 126 µM -1.09458190079846 0.236336746200831 no 2698 0.136849924223731 4142 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_112 phenothiazine 287.218 µM -1.09472185048467 0.236312033490482 no 2699 0.136819256428879 4149 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_694 1315-0438 43.2 µM -1.09744134099194 0.235832100746352 no 2700 0.136224254929899 4186 6793154
SGTC_2212 7123476 200 µM -1.09820820552773 0.235696862515325 no 2701 0.136056791997854 4165 1085715
SGTC_2412 st077135 33.4 µM -1.10110702330145 0.23518603629917 no 2702 0.135425040337649 4275 13258915
SGTC_2278 7948257 134.34 µM -1.10228138987384 0.234979264962407 no 2703 0.135169678729824 4192 1247028
SGTC_2928 9011484 9.79 µM -1.10273731519053 0.234899017028756 no 2704 0.135070628504362 4209 2994751
SGTC_992 3909-8734 162 µM -1.1029412874099 0.234863120550534 no 2705 0.135026331457618 4214 4288319
SGTC_1758 st042942 75.2445 µM -1.10301908829988 0.234849429396771 no 2706 0.135009437911036 4167 669317
SGTC_2061 5245884 80.95 µM -1.1036551595064 0.234737512151561 no 2707 0.134871376915661 4167 573863
SGTC_320 4092-0846 5.34 µM -1.104201761404 0.234641360665858 no 2708 0.134752812880972 4147 1359356
SGTC_2428 5615643 7.78 µM -1.10472066340401 0.234550101961801 no 2709 0.134640323455087 4223 2253075
SGTC_1031 k035-0009 16 µM -1.10706179712963 0.234138613641964 no 2710 0.134133605574445 4269 5180959
SGTC_1571 st070080 73.4 µM -1.10795637877869 0.23398148352 no 2711 0.133940327594706 4231 4315245
SGTC_26 0302-0163 425.158 µM -1.10796530516341 0.233979915926305 no 2712 0.133938399978102 4256 3100915
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.10919355709949 0.233764273784732 no 2713 0.133673345720429 4234 61125 An anti-inflammatory.
SGTC_2835 9006588 71.43 µM -1.10936620897232 0.233733970416636 no 2714 0.133636116728564 4260 2345538
SGTC_2308 7584454 197.62 µM -1.11322736919343 0.233056839672166 no 2715 0.132805395454134 4271 893577
SGTC_1048 3161-0300 24.5 µM -1.11653017835061 0.232478492262925 no 2716 0.132097629913036 4195 2165101
SGTC_1892 st058411 7.36 µM -1.11881344852697 0.232079141063542 no 2717 0.131609866557106 4222 3934738
SGTC_41 0478-0632 82.643 µM -1.12096510632193 0.231703159048461 no 2718 0.131151357791097 4176 3750424
SGTC_2983 9022671 12.99 µM -1.12306806462479 0.23133601501815 no 2719 0.130704294018017 4215 6405161
SGTC_1944 st076371 56.9 µM -1.12378844510654 0.231210322367078 no 2720 0.130551392281535 4181 24208455
SGTC_2565 isoliquiritigenin 100 µM -1.12527465087872 0.230951128243749 no 2721 0.130236334019835 4309 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1769 st044406 64.4 µM -1.12796777028655 0.230481862089357 no 2722 0.129666765378919 4192 670903
SGTC_166 k072-0058 166.424 µM -1.12973728545395 0.230173820942576 no 2723 0.129293470615108 4118 5846229
SGTC_2943 9068529 45.32 µM -1.13060110410793 0.230023529159847 no 2724 0.129111511298576 4206 3270634
SGTC_2127 5253358 187.912 µM -1.13144531889698 0.229876701238257 no 2725 0.128933853063997 4115 20612
SGTC_1855 st056195 39.6 µM -1.13265735648989 0.229665992433759 no 2726 0.128679086025812 4166 4028379
SGTC_491 tetrandrine 80.3 µM -1.13291023433303 0.229622044084789 no 2727 0.128625975855423 4236 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_362 0310-0100 9.03 µM -1.13541610990911 0.229186795681467 no 2728 0.128100506446667 4293 790235
SGTC_14 0354-0009 295 µM -1.13906207644062 0.228554350670024 no 2729 0.127338631806894 4315 1713507
SGTC_699 0375-0592 111 µM -1.13984264607691 0.228419077224217 no 2730 0.127175931550734 4308 762578
SGTC_173 1273-0061 2.693 µM -1.14018120105106 0.228360419321976 no 2731 0.127105408870775 4204 2847414 YPL266W DIM1
SGTC_579 4491-1009 110 µM -1.14022868083943 0.228352193669326 no 2732 0.127095520771647 4342 1271041
SGTC_1296 1068-0102 11.9 µM -1.14224131165599 0.228003667898855 no 2733 0.12667686423226 4225 767053
SGTC_1866 st057638 64 µM -1.1441661078657 0.227670632470487 no 2734 0.126277377909311 4218 688802
SGTC_2177 5811945 192 µM -1.14679693277008 0.227215880584323 no 2735 0.125732778591301 4283 5343475
SGTC_1219 1469-0211 33.1 µM -1.14879192685075 0.22687137695695 no 2736 0.125320894550601 4271 6822282
SGTC_2147 5545932 89.7195 µM -1.14899349706015 0.22683658539631 no 2737 0.12527933106674 4265 797404
SGTC_2068 5226020 147 µM -1.1495593164963 0.226738939523287 no 2738 0.12516271135064 4254 1810509
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -1.15288257966498 0.226165908812538 no 2739 0.124479291598391 4228 688667
SGTC_125 0133-0007 11.75 µM -1.15307429633786 0.22613287606676 no 2740 0.124439945357187 4329 26541
SGTC_141 0443-0274 32.331 µM -1.15387883549239 0.225994283858199 no 2741 0.124274923651265 4226 1627241
SGTC_3334 9142812 21.919 µM -1.15483782597486 0.225829148172497 no 2742 0.124078421957277 4248 45283678
SGTC_948 3448-0295 75.3 µM -1.15904845901605 0.225104896198017 no 2743 0.123218216485971 4226 678569
SGTC_2729 fluphenazine 10.66 µM -1.15987655158225 0.224962614752207 no 2744 0.1230495354165 4178 3372 An atypical antipsychotic.
SGTC_2201 6605497 169.863 µM -1.16103985478412 0.224762824113112 no 2745 0.122812846026488 4185 670741
SGTC_2463 5473429 200 µM -1.16181099413768 0.2246304408353 no 2746 0.12265612362949 4237 5399405
SGTC_3029 9088683 49.47 µM -1.16439478791948 0.224187197495378 no 2747 0.122132029422084 4280 25236615
SGTC_1208 2323-2347 50.3 µM -1.16655091754751 0.223817699335248 no 2748 0.121695887323027 4248 5412760
SGTC_2192 5915882 198.485 µM -1.16881777405471 0.223429599334393 no 2749 0.121238528830431 4226 2876149
SGTC_1398 3558-0053 112 µM -1.17385546510326 0.222568487466156 no 2750 0.120226461628398 4199 4532369
SGTC_1430 4049-0248 69.1 µM -1.17448863323012 0.22246039162537 no 2751 0.120099681100756 4271 22774488
SGTC_947 3447-0010 211 µM -1.17590109949533 0.222219360234963 no 2752 0.119817199733665 4221 748350
SGTC_2700 st077718 96.8 µM -1.17786581754272 0.221884337357592 no 2753 0.119425052165665 4269 904970
SGTC_231 b-estradiol 524 µM -1.17974985660368 0.221563342934407 no 2754 0.119049859092984 4241 450 A steroid.
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.18019671815119 0.221487247557627 no 2755 0.118960992010326 4321 6710655
SGTC_2139 5578692 56.4705 µM -1.18058966535818 0.221420345519276 no 2756 0.118882885556 4234 650991 YMR113W FOL3
SGTC_1212 0520-0165 585 µM -1.18448417838516 0.220757902200974 no 2757 0.118110727814058 4394 5403258
SGTC_786 4544-0069 423 µM -1.18500096212756 0.220670084434903 no 2758 0.118008533250094 4258 748821 YLR208W SEC13
SGTC_1004 4084-0029 199 µM -1.18607770405938 0.220487176505457 no 2759 0.117795807290636 4287 716894 YLR208W SEC13
SGTC_1143 3454-2408 5.08 µM -1.18818839897201 0.220128881472189 no 2760 0.117379596593103 4276 X1143
SGTC_2045 5106652 78.05 µM -1.18873036477432 0.220036935515538 no 2761 0.11727289388647 4251 673349
SGTC_3285 9112818 20.8695 µM -1.19295498047057 0.219320973754454 no 2762 0.116443502453612 4248 17017947 YPR165W RHO1
SGTC_2020 4017018 200 µM -1.19423186407981 0.219104839180657 no 2763 0.116193641000981 4338 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_196 k015-0023 18.111 µM -1.19581960784253 0.218836257065287 no 2764 0.115883481238596 4221 5211998
SGTC_2787 5284540 71.43 µM -1.19631184961899 0.218753028122231 no 2765 0.11578744315002 4307 736958
SGTC_990 3985-0011 41.3 µM -1.19676903764059 0.218675742437554 no 2766 0.11569829481339 4255 5399565 YGL099W LSG1
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.1972547293245 0.218593655550018 no 2767 0.115603641889026 4303 6708760
SGTC_2933 9026794 32.47 µM -1.20140414266156 0.217893085590215 no 2768 0.114797234974415 4232 17586027
SGTC_1201 1889-3372 45.9 µM -1.20310893458386 0.217605631190375 no 2769 0.11446708419053 4156 5392199
SGTC_203 k066-0004 30.888 µM -1.20331790532753 0.217570410540054 no 2770 0.114426661371202 4362 6795412
SGTC_1428 4049-0204 61.7 µM -1.20479798811866 0.217321046470222 no 2771 0.114140648434375 4329 X1428
SGTC_2708 st078559 56 µM -1.20831997867058 0.216728326270961 no 2772 0.113462103285924 4232 17250902
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.20950498930077 0.216529109735951 no 2773 0.113234447717718 4196 6708630 An antioxidant.
SGTC_2275 7947463 200 µM -1.21036292873891 0.216384944497672 no 2774 0.113069830168404 4256 1225414
SGTC_1530 rhein 70.4 µM -1.21045965412023 0.216368694577556 no 2775 0.113051281656545 4348 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_617 3770-0098 35 µM -1.21154191555688 0.216186922200717 no 2776 0.112843890201855 4209 5962639
SGTC_646 4092-0839 27.3 µM -1.21261293427609 0.216007125190818 no 2777 0.112638920700177 4318 877796
SGTC_874 0599-0792 117 µM -1.21393723670971 0.215784928059534 no 2778 0.112385846071726 4312 765305
SGTC_1371 2421-0008 32.7 µM -1.21618905232565 0.215407413105033 no 2779 0.111956456561999 4281 2827552
SGTC_1308 1187-1617 41.4 µM -1.21642627496033 0.215367665254867 no 2780 0.111911289938829 4325 2882570
SGTC_559 1550-0661 158 µM -1.21673069740276 0.215316663972473 no 2781 0.111853347724329 4350 5830875
SGTC_1677 st019204 53.9 µM -1.21888145340475 0.214956537712227 no 2782 0.111444594982757 4325 3945625
SGTC_1022 4477-0945 21.3 µM -1.21960892961794 0.214834807067964 no 2783 0.111306579846677 4249 4648966
SGTC_1846 st056244 14.8 µM -1.22089835407595 0.214619142467601 no 2784 0.111062253879039 4324 5393182
SGTC_1641 st009299 47.1 µM -1.22113027479589 0.214580365579971 no 2785 0.111018349279895 4238 4046054
SGTC_1939 st074455 53.6 µM -1.22340258503079 0.214200653307257 no 2786 0.110588838741398 4295 1644229
SGTC_2097 5376186 200 µM -1.22444666363338 0.214026314692845 no 2787 0.110391887576943 4293 742755
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.22629507522666 0.213717872431726 no 2788 0.110043826975946 4357 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_245 methotrexate 289.6 µM -1.22837932950375 0.213370386152481 no 2789 0.109652301861101 4269 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1702 st027038 51 µM -1.23018516980575 0.213069583452178 no 2790 0.109313886027818 4334 5521182
SGTC_169 k015-0017 16.025 µM -1.23227584482514 0.212721644405357 no 2791 0.108923029893918 4298 1840002
SGTC_2193 5925765 200 µM -1.2325755559837 0.212671792398094 no 2792 0.108867080694753 4319 877370
SGTC_1036 k216-0215 33.5 µM -1.23438886305096 0.21237032420812 no 2793 0.108529018487474 4266 622330
SGTC_1207 2099-0101 141 µM -1.23452513203534 0.212347679139283 no 2794 0.108503643849085 4316 5837381
SGTC_341 1486-1430 230 µM -1.23477976515011 0.212305368197697 no 2795 0.10845624007359 4272 2054753 YPL210C SRP72
SGTC_1926 methyl fluorone black 53.6 µM -1.23579399489429 0.212136888293337 no 2796 0.10826757386114 3967 72721 Reacts with homocysteine.
SGTC_2746 daunorubicin 9.88 µM -1.24007781086729 0.211426140307668 no 2797 0.107473307638573 4298 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_135 0933-0004 26.348 µM -1.24326986108663 0.210897440221318 no 2798 0.106884203230841 4284 21230617 YGL099W LSG1
SGTC_793 0488-0545 106 µM -1.24453213428084 0.210688583672804 no 2799 0.106651890102222 4344 292548
SGTC_1558 st069300 45.6 µM -1.25081322474409 0.209651115983664 no 2800 0.105501314397003 4277 24208000
SGTC_2973 9094665 17.96 µM -1.25238764133073 0.209391536277615 no 2801 0.105214323710286 4330 25237061 YIL048W NEO1
SGTC_2720 fluspirilene 36.88 µM -1.25451774856992 0.2090406390602 no 2802 0.104826939361304 4314 3396 An atypical antipsychotic.
SGTC_924 2046-0044 21.3 µM -1.25516814592393 0.208933566735538 no 2803 0.104708863234863 4311 3623589
SGTC_2336 9001819 198.65 µM -1.25603203127118 0.208791398698111 no 2804 0.104552178496047 4386 2989602
SGTC_3069 9117009 49.47 µM -1.25668300756664 0.208684306387114 no 2805 0.104434221797252 4323 41904981
SGTC_3194 9111903 49.47 µM -1.25728655294498 0.208585045880341 no 2806 0.104324945737759 4356 17087251
SGTC_1059 3448-6867 171 µM -1.25751438625798 0.208547583110438 no 2807 0.104283716495184 4301 3934407
SGTC_3315 9136395 68.55 µM -1.25887623316101 0.208323736538331 no 2808 0.104037519780994 4320 16876844
SGTC_3195 9113082 49.47 µM -1.2602165105615 0.208103573788674 no 2809 0.103795634186085 4340 17018038
SGTC_1781 st038725 66.3 µM -1.26054826521383 0.208049098805647 no 2810 0.103735824041745 4333 4270275 YIL048W NEO1
SGTC_406 estrone 100 µM -1.26097874734021 0.207978425061623 no 2811 0.103658252163584 4311 5870 A steroid.
SGTC_2539 epi(13)torulosol 80 µM -1.26161221392502 0.207874452433107 no 2812 0.103544179507053 4324 6708597
SGTC_1016 4226-1401 38 µM -1.26232627081523 0.20775728910181 no 2813 0.103415703659181 4323 2901613
SGTC_75 0159-0059 199.013 µM -1.26259777380863 0.207712750794525 no 2814 0.103366884177182 4415 5377270
SGTC_1764 st044502 93.5 µM -1.26299575595249 0.207647474596694 no 2815 0.10329535247235 4367 8407
SGTC_1274 0865-0114 173 µM -1.26314966679339 0.207622233713183 no 2816 0.103267698797923 4332 870624
SGTC_1728 st035614 33.7865 µM -1.26335850448076 0.207587987902242 no 2817 0.103230184829302 4278 15945546
SGTC_2591 skatole 100 µM -1.26350961684662 0.207563210138842 no 2818 0.103203046357104 4360 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2711 st079103 59.1 µM -1.26444351273462 0.20741011882222 no 2819 0.103035441683453 4285 54693780
SGTC_2781 5567276 71.43 µM -1.26448975024677 0.207402540952202 no 2820 0.103027148657162 4359 2853274
SGTC_637 1181-0519 7.26 µM -1.264694847122 0.207368929580145 no 2821 0.102990368920603 4335 6252091 YGR060W ERG25
SGTC_1619 st003326 88.7 µM -1.26646969807478 0.207078200714233 no 2822 0.102672485717484 4318 2849032
SGTC_839 0122-0028 230 µM -1.2675156132935 0.206906987902421 no 2823 0.102485492211648 4356 759448
SGTC_749 1000-0129 128 µM -1.27195932537941 0.206180501845552 no 2824 0.101693785736038 4391 708470
SGTC_1415 3966-0071 78.1 µM -1.27488224185849 0.205703470601471 no 2825 0.101175462718963 4260 2893185
SGTC_1508 1080-0625 72.9 µM -1.2751041128288 0.205667287170799 no 2826 0.10113619692862 4259 767111
SGTC_3187 9109394 49.47 µM -1.2754559625487 0.205609914134251 no 2827 0.101073950819139 4351 17098090
SGTC_1875 nocodazole 6 µM -1.27571293185415 0.205568018415496 no 2828 0.101028507751979 4371 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1309 pyrazolanthrone 13.4 µM -1.27682236804404 0.205387196526125 no 2829 0.100832483346325 4320 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1218 1348-1416 30.7 µM -1.27708790989147 0.205343931099854 no 2830 0.100785606367381 4306 6787668
SGTC_2795 7780010 54.55 µM -1.27762827982727 0.205255903934799 no 2831 0.100690262158528 4317 953673
SGTC_700 3453-2283 142 µM -1.27800715639902 0.205194197680546 no 2832 0.100623451482131 4386 565664
SGTC_1770 st043884 66.3 µM -1.27843424239502 0.205124652949382 no 2833 0.100548178385978 4356 670149
SGTC_1472 k841-0093 193 µM -1.27853156362334 0.205108807565295 no 2834 0.100531031452705 4467 X1472
SGTC_1947 st076332 61.6 µM -1.28515536344061 0.204032062166169 no 2835 0.099368999093616 4234 24208416
SGTC_602 3130-1533 38.1 µM -1.28891804730421 0.203421914058113 no 2836 0.0987132895717623 4400 720941
SGTC_1529 apigenin 74 µM -1.29002423384464 0.203242744673874 no 2837 0.0985211220656235 4368 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_623 k072-0108 16.9 µM -1.29056562114904 0.203155090340082 no 2838 0.0984271717671976 4332 5382803
SGTC_1897 st060201 15 µM -1.2946618278113 0.202492617895436 no 2839 0.0977184567924033 4371 611878
SGTC_252 miconazole 1.30953 nM -1.29485394693972 0.202461578541095 no 2840 0.0976853089338941 4261 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_675 1309-0189 238 µM -1.29845280299962 0.201880662264526 no 2841 0.0970658922765615 4362 4246530
SGTC_1094 duloxetine 25.4 µM -1.29881733578044 0.201821876214471 no 2842 0.0970033119203744 4388 60834 A selective serotonin reuptake inhibitor.
SGTC_1959 st077091 55.8 µM -1.29887757266002 0.201812163155315 no 2843 0.0969929737397902 4370 821356 YKL052C ASK1
SGTC_2060 5238662 140 µM -1.3009007626032 0.201486091009101 no 2844 0.0966462125306511 4332 790130
SGTC_727 3032-0951 202 µM -1.30344532718897 0.201076438816691 no 2845 0.0962113851339074 4407 3652836
SGTC_1808 st050063 61.5 µM -1.30394816724611 0.20099554520731 no 2846 0.096125627851242 4344 4011993
SGTC_1064 honokiol 6.76 µM -1.30820720255312 0.20031116283463 no 2847 0.0954015198888148 4397 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2634 4'-methoxyflavone 100 µM -1.30837212193257 0.20028469020493 no 2848 0.0953735617795422 4373 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_3150 9097574 49.47 µM -1.30855821409394 0.200254821474083 no 2849 0.0953420215782975 4407 17217476
SGTC_2656 pseudo-anisatin 100 µM -1.30984247613271 0.20004876392162 no 2850 0.0951245651963795 4427 6708809 A neurotoxin.
SGTC_553 k007-0256 45.7 µM -1.31456844145566 0.199291589503904 no 2851 0.09432749107435 4434 6287000
SGTC_2607 solasodine 47.35 µM -1.31489936753107 0.199238634644324 no 2852 0.0942718626742725 4345 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2967 9089538 49.85 µM -1.31505212061231 0.199214193923386 no 2853 0.0942461931712767 4371 728216
SGTC_2178 5812956 200 µM -1.31726186959371 0.198860832836351 no 2854 0.0938754308540645 4335 5403383
SGTC_3270 9137563 49.47 µM -1.31844871110769 0.198671200994896 no 2855 0.0936767417932135 4369 17015724
SGTC_1631 benzylvanillin 81.9 µM -1.31848355526356 0.198665635293702 no 2856 0.0936709132305766 4435 75506
SGTC_1160 4092-0570 10.5 µM -1.32067985783293 0.198315006878905 no 2857 0.0933040664567589 4386 4994975
SGTC_3196 9111891 49.47 µM -1.32268763432235 0.197994802671392 no 2858 0.0929696387294103 4363 18891510
SGTC_728 3030-5151 22.5 µM -1.32414027355479 0.19776332766211 no 2859 0.0927282311689584 4464 3125388
SGTC_1255 0566-0045 221 µM -1.32892297636087 0.197002370286412 no 2860 0.0919366913224181 4402 2788469
SGTC_1723 st034307 2.5525 µM -1.33118386604308 0.196643266628114 no 2861 0.0915642594015076 4392 867466
SGTC_2778 tioconazole 65.09 nM -1.33125095915401 0.196632616096696 no 2862 0.0915532243916037 4281 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1729 st035615 45.989 µM -1.3324091010241 0.196448824787329 no 2863 0.091362896551556 4397 17385451
SGTC_3171 9103192 49.47 µM -1.33261495041501 0.196416168421 no 2864 0.0913290981973857 4471 13018434
SGTC_2927 9011802 47.9 µM -1.33396895414655 0.196201448519357 no 2865 0.0911070156782557 4371 43912568
SGTC_57 miconazole 162.5 nM -1.33793988498767 0.195572553753759 no 2866 0.0904580169924089 4238 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_126 0417-1624 672.48 µM -1.33807574346125 0.195551058893989 no 2867 0.0904358735207372 4444 41912 YDL195W SEC31
SGTC_810 3825-7150 143 µM -1.34043273322458 0.195178375935229 no 2868 0.0900523498841126 4432 22330411 YGL099W LSG1
SGTC_2337 9009472 200 µM -1.34049308866077 0.195168838314509 no 2869 0.0900425448878318 4366 5742383
SGTC_449 xestospongin c 11.1929 µM -1.34140581978944 0.195024639223128 no 2870 0.0898943645367652 4405 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1658 st012944 20 µM -1.34244057118882 0.194861240951777 no 2871 0.0897265936877698 4238 24207260
SGTC_1697 st025554 27.742 µM -1.34548282416648 0.194381319243757 no 2872 0.0892346821562786 4414 1269519
SGTC_1942 st076330 65.2 µM -1.34990920749989 0.193684334634629 no 2873 0.0885225539330904 4453 24208414
SGTC_1077 5-fluorocytosine 377 nM -1.35526561443541 0.19284294788695 no 2874 0.0876664731129854 4459 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2120 5538279 151.968 µM -1.35527593287422 0.192841329219814 no 2875 0.0876648299640179 4370 2058197
SGTC_574 1315-0397 40 µM -1.35701262502715 0.192569010293915 no 2876 0.0873885995251089 4381 6794277
SGTC_3216 9129716 49.47 µM -1.3587106594167 0.192302980417572 no 2877 0.0871191465008614 4332 8056934
SGTC_206 4546-0025 72.014 µM -1.36187455925217 0.191807894361758 no 2878 0.0866187381329936 4453 6620745 YIL048W NEO1
SGTC_1315 1237-0019 3.69 µM -1.36421392033348 0.191442334175227 no 2879 0.0862501241457377 4410 825140
SGTC_1878 temozolomide 1 mM -1.36550915229449 0.191240118534666 no 2880 0.0860465392493783 4352 5394 DNA alkylating agent.
SGTC_372 0155-0182 15.9 µM -1.37381056228383 0.18994718790581 no 2881 0.0847502505975551 4307 771486
SGTC_817 1391-0715 46 µM -1.37430244882504 0.189870746414794 no 2882 0.0846739032020801 4393 1353946
SGTC_1835 st008666 49.2 µM -1.37485303911908 0.189785204521888 no 2883 0.0845885053921604 4363 690455
SGTC_3140 9094243 49.47 µM -1.37750395003163 0.189373680321668 no 2884 0.0841782471975035 4370 19291112
SGTC_496 calpeptin 138 µM -1.37820576906259 0.189264822805656 no 2885 0.0840698832920121 4416 73364 A calpain inhibitor.
SGTC_255 tunicamycin 200.472 nM -1.37949063812379 0.189065629606848 no 2886 0.083871765366114 4344 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2370 9071495 200 µM -1.3865510897669 0.187973353886581 no 2887 0.0827893456323966 4427 21791103
SGTC_995 3931-2021 34.6 µM -1.38713821194232 0.187882699889046 no 2888 0.0826998110119845 4439 730143
SGTC_2000 st075254 36.4 µM -1.39072905041251 0.187328847810266 no 2889 0.0821538024475296 4317 17234175
SGTC_2678 equilin 100 µM -1.39361923174226 0.18688379927052 no 2890 0.0817163089264304 4420 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2887 9044784 58.44 µM -1.39362008695378 0.186883667676507 no 2891 0.081716179731491 4367 6465546
SGTC_176 1486-1328 72.834 µM -1.39447373045251 0.186752343535251 no 2892 0.0815872984397759 4466 22310231
SGTC_893 0958-0369 48.9 µM -1.39501471571271 0.186669148178577 no 2893 0.0815057010080591 4321 6819948
SGTC_2821 7996764 71.43 µM -1.39755711180037 0.186278473466259 no 2894 0.0811230525119629 4440 2987135
SGTC_2822 7994718 71.43 µM -1.39927170480968 0.186015288533762 no 2895 0.0808657606283731 4437 1018011
SGTC_1557 sumaresinolic acid 42.3 µM -1.40752333380991 0.184751915034095 no 2896 0.0796361315591039 4401 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1205 4161-2785 76 µM -1.40819066511139 0.184649976301534 no 2897 0.0795373098363995 4451 3498106
SGTC_219 mitoxanthrone 164.414 µM -1.41140513702492 0.184159437153648 no 2898 0.0790625945643005 4385 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2986 9022445 71.43 µM -1.42023074599795 0.182816795613677 no 2899 0.0777702576885581 4428 6459286
SGTC_3037 9091026 49.47 µM -1.42135985252992 0.182645466364585 no 2900 0.0776060858297042 4326 25236398 YIL048W NEO1
SGTC_180 1486-1293 102.781 µM -1.42320388086188 0.182365871416972 no 2901 0.0773385304622756 4389 4140536
SGTC_2093 5331342 194.4 µM -1.42476685558319 0.182129099836843 no 2902 0.0771123030903361 4487 33839
SGTC_441 propafenone 146 µM -1.42604962125571 0.181934920149641 no 2903 0.0769270096148525 4437 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2378 9074213 121.43 µM -1.42644937254146 0.181874433946322 no 2904 0.0768693353978411 4420 657714
SGTC_3152 9099253 49.47 µM -1.42720477583396 0.181760168527997 no 2905 0.0767604391569445 4322 25236131
SGTC_1102 cgs 12066b 26.1 µM -1.4273286538779 0.181741434511297 no 2906 0.0767425925412238 4458 6438352 A 5-HT1B full agonist.
SGTC_2725 haloperidol 53.21 µM -1.43041628874725 0.181274883334833 no 2907 0.0762987879865669 4415 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1497 4476-2978 41.3 µM -1.431912692269 0.181049042215142 no 2908 0.0760844046894106 4487 1528379
SGTC_2194 5927483 104.545 µM -1.43327487793623 0.180843610950915 no 2909 0.0758896492005355 4500 760979
SGTC_1454 4239-0054 42.6 µM -1.43381844798239 0.180761675935001 no 2910 0.0758120395299492 4523 1340767
SGTC_412 gemfibrozil 100 µM -1.43487953325475 0.18060180034398 no 2911 0.0756607144291117 4402 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_1787 fluconazole 80 µM -1.43753955740269 0.180201399758658 no 2912 0.0752823706196914 4146 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1594 piperine 70.1 µM -1.4386898688081 0.180028421642932 no 2913 0.0751192055258815 4454 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1072 oxiconazole 14.9 nM -1.43881613229605 0.180009441118661 no 2914 0.0751013122093171 4450 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2249 haloperidol 116.36 µM -1.43931867185689 0.17993390945021 no 2915 0.0750301274778962 4411 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2771 fluoxetine 41.05 µM -1.43960527077168 0.179890842562519 no 2916 0.0749895537883457 4445 3386 A selective serotonin reuptake inhibitor.
SGTC_658 3253-0951 102 µM -1.44294695059656 0.179389170106932 no 2917 0.074517707885367 4479 1184878
SGTC_205 1486-1330 71.903 µM -1.44684800167097 0.178804635545308 no 2918 0.0739697496340531 4533 4118834
SGTC_2681 menadione 3.18 µM -1.44688725396849 0.178798760069679 no 2919 0.0739642517765097 4481 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3263 9137018 49.47 µM -1.44704307667912 0.178775436964099 no 2920 0.0739424296100403 4418 43844957
SGTC_2946 9065502 71.43 µM -1.44717428777507 0.178755799141309 no 2921 0.0739240579889091 4317 16489101
SGTC_1591 genipin 88.4 µM -1.45084123781367 0.178207531270796 no 2922 0.0734120368669862 4478 442424 A DNA cross-linking agent.
SGTC_263 alizarin 107.927 µM -1.45093276166691 0.178193860556969 no 2923 0.0733992920515854 4504 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2263 7948595 193.29 µM -1.45306045842549 0.177876237553566 no 2924 0.073103484246083 4485 2971371
SGTC_344 k064-0035 6.43 µM -1.45481075071302 0.177615221427126 no 2925 0.0728608305489341 4426 5088750
SGTC_2826 7992541 19.48 µM -1.45549664196971 0.177513002359086 no 2926 0.0727659095983665 4471 2985066
SGTC_2961 9083290 32.55 µM -1.45807986620528 0.177128355194574 no 2927 0.0724092651396407 4426 17741490
SGTC_2069 5228469 200 µM -1.46135380459766 0.176641616444754 no 2928 0.0719591856132082 4475 2835210
SGTC_2506 ethyl hematommate 54.16 µM -1.4702375092989 0.175325135806906 no 2929 0.0707487195571539 4498 3940691 An allergen.
SGTC_583 1488-1091 88.9 µM -1.47087022031838 0.175231611956313 no 2930 0.0706631087998982 4575 4303273
SGTC_364 0083-0097 67.7 µM -1.47154173541816 0.175132386915707 no 2931 0.0705723346568946 4499 5207356
SGTC_103 0844-0104 51.839 µM -1.47208232614998 0.175052533542822 no 2932 0.0704993237643126 4303 5375804
SGTC_3269 9137823 49.47 µM -1.47513969627346 0.174601348880822 no 2933 0.0700874950151585 4418 17682936
SGTC_2937 9044753 11.33 µM -1.47570837547783 0.174517508821115 no 2934 0.0700110982826902 4415 6465530 YGL099W LSG1
SGTC_1045 1348-1485 165 µM -1.47866787749102 0.174081603949164 no 2935 0.0696145507906536 4461 6810614
SGTC_3135 9127742 49.47 µM -1.48147479480006 0.173668813365996 no 2936 0.0692400483220368 4538 3643468
SGTC_2063 5246145 200 µM -1.48224901952117 0.173555064074884 no 2937 0.0691370238750429 4519 711240
SGTC_866 0495-0101 262 µM -1.48554385752508 0.173071516013541 no 2938 0.0686999072780471 4494 635694
SGTC_279 1273-0055 2.93 µM -1.48715201595755 0.17283581579424 no 2939 0.0684873329991344 4527 2847562
SGTC_3228 9131799 49.47 µM -1.48987398872536 0.1724373354534 no 2940 0.0681286860264389 4512 17015818
SGTC_1406 3909-7906 11.9 µM -1.49106371924031 0.172263350288478 no 2941 0.0679723832596702 4527 X1406
SGTC_202 3594-0513 34.79 µM -1.49120032743929 0.172243379994617 no 2942 0.0679544538730134 4568 708429
SGTC_765 1319-0117 244 µM -1.49172550423826 0.172166619918625 no 2943 0.0678855601113491 4463 3487746 YGL099W LSG1
SGTC_3151 9099821 49.47 µM -1.49396978454932 0.171838840934121 no 2944 0.0675917584687507 4427 17174189
SGTC_1085 doxorubicin 7.67 µM -1.49500942001915 0.171687136471739 no 2945 0.0674559918521006 4496 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_443 clozapine 122 µM -1.49592433060483 0.171553702763855 no 2946 0.0673366875651966 4487 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2757 clomiphene 4.22 µM -1.49702455363144 0.171393330233105 no 2947 0.067193434630624 4496 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1967 st070177 51.4 µM -1.49734963032622 0.171345964211093 no 2948 0.0671511536220015 4504 5729214
SGTC_361 000s-0510 1.45 µM -1.49811504256998 0.171234471169783 no 2949 0.0670516817420434 4388 660
SGTC_957 1187-1561 14.1 µM -1.49864220889592 0.17115770897394 no 2950 0.066983238259256 4443 1538454
SGTC_1435 4092-0789 56.7 µM -1.49897226868272 0.171109659228755 no 2951 0.0669404131877857 4491 2248285
SGTC_3012 9080433 71.4286 µM -1.49945286722817 0.171039709642866 no 2952 0.0668780936731283 4482 17688859
SGTC_3076 9116187 49.47 µM -1.49959337247817 0.17101926300763 no 2953 0.0668598827510379 4495 27241210
SGTC_251 melphalan 456.522 µM -1.50304065288274 0.170518096952028 no 2954 0.0664142805571502 4529 460612 A DNA alkylator.
SGTC_1426 4048-4480 71.7 µM -1.50524612206988 0.170197959361488 no 2955 0.0661304056690777 4499 14224343
SGTC_1138 3761-0006 1.03 µM -1.50536376710439 0.170180893278137 no 2956 0.0661152895465983 4525 12061087
SGTC_2143 5623677 140.463 µM -1.50684043936236 0.169966774257348 no 2957 0.0659257806122903 4451 5375313
SGTC_2910 7948405 25.97 µM -1.50846069965165 0.169732033616606 no 2958 0.0657183289055678 4458 2971328
SGTC_3326 9140064 16.379 µM -1.51034011311466 0.169460007892208 no 2959 0.0654783305957436 4455 1868434
SGTC_2557 derrustone 83.84 µM -1.51120766639093 0.16933453292858 no 2960 0.0653677748856633 4472 629853 An antioxidant.
SGTC_2346 9031566 143.75 µM -1.51943623945489 0.16814739378086 no 2961 0.0643263629419972 4479 4771086
SGTC_2504 purpurogallin 52.29 µM -1.52005397106857 0.168058490026812 no 2962 0.0642487058423976 4443 5281571 An antioxidant.
SGTC_570 0987-0065 62.6 µM -1.52195307407107 0.167785361162757 no 2963 0.0640104195747616 4362 3104428
SGTC_3272 9137413 49.47 µM -1.52203880044814 0.16777303874683 no 2964 0.0639996794552938 4448 17614870
SGTC_2431 5490079 200 µM -1.52510217744024 0.167333087615912 no 2965 0.0636168071049674 4540 5722345
SGTC_620 0109-0052 432 µM -1.52519686839952 0.167319500299604 no 2966 0.0636050007320635 4555 493037
SGTC_2915 7971052 15.16 µM -1.52597021659969 0.167208558281846 no 2967 0.0635086410067162 4459 5741558
SGTC_102 gallobenzophenone 83.616 µM -1.52730833772836 0.167016707813509 no 2968 0.0633421785845882 4485 70837
SGTC_2658 polymyxin b sulfate 77.05 µM -1.52794495010367 0.166925484626024 no 2969 0.0632631032609438 4524 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_1044 1222-0021 1.78 µM -1.54531039740517 0.164449507456514 no 2970 0.0611356008580965 4436 4306703
SGTC_2698 st077697 67.5 µM -1.55014173994947 0.163764906051867 no 2971 0.0605537498008148 4495 3154499
SGTC_1460 k062-0059 9.15 µM -1.55064705877593 0.163693409369904 no 2972 0.0604931440579977 4406 1373085
SGTC_3009 9080819 71.4286 µM -1.5524061108076 0.163444682228512 no 2973 0.0602825411092771 4530 17027216
SGTC_2140 5586273 200 µM -1.55483122073076 0.163102178268403 no 2974 0.05999313571157 4497 854421
SGTC_1995 st072814 61.1 µM -1.56039300058747 0.162318438107708 no 2975 0.0593335189411845 4533 5769371
SGTC_1613 st002381 52.1 µM -1.56354951228612 0.161874729454506 no 2976 0.0589616997222491 4532 551167
SGTC_1124 fisetin 1.16336 µM -1.56371738297663 0.161851154140266 no 2977 0.0589419768168111 4535 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_3299 9121982 43.1275 µM -1.56784903349944 0.161271621262801 no 2978 0.0584581842566294 4532 17594604 YPL160W CDC60
SGTC_2047 4141938 200 µM -1.57382429115351 0.160435889118531 no 2979 0.0577640383087055 4551 3807862
SGTC_2505 galangin 7.89 µM -1.57520530507013 0.160243136281551 no 2980 0.0576045315349253 4458 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2840 9008771 71.43 µM -1.5759411381257 0.160140495382965 no 2981 0.0575196845651551 4469 2992978
SGTC_851 0394-0702 453 µM -1.58288726866625 0.159173702346106 no 2982 0.0567235805216824 4541 762646
SGTC_674 0498-0004 451 µM -1.58879113186831 0.158354988594131 no 2983 0.0560537780316282 4533 4231473
SGTC_1930 st074634 34.3 µM -1.58943375482346 0.158266040364843 no 2984 0.0559812494667502 4451 684253 YOR116C RPO31
SGTC_3352 9151559 45.5865 µM -1.59758386875789 0.157140792822893 no 2985 0.0550678094174594 4541 17159339
SGTC_2768 sulfasalazine 50.2 µM -1.59892885311756 0.156955604224018 no 2986 0.0549182060537777 4519 5384001 An antioxidant and salicylic acid derivative.
SGTC_2087 5276107 200 µM -1.59967857250755 0.156852438988009 no 2987 0.0548349538741517 4536 144405
SGTC_2936 9038235 15.59 µM -1.60292316708498 0.156406480619258 no 2988 0.0544758090924593 4466 4749415
SGTC_2894 9048625 32.47 µM -1.60736110178899 0.155797855239188 no 2989 0.0539875889014901 4548 4092861
SGTC_1167 k781-0610 148 µM -1.6085113659513 0.155640361359965 no 2990 0.0538616144665021 4584 4525169
SGTC_2571 chrysanthemic acid 100 µM -1.61130806059628 0.155257876806065 no 2991 0.0535562973819619 4541 2743 An insecticide.
SGTC_731 3966-0296 387 µM -1.61497661264762 0.154757095809253 no 2992 0.0531578798251905 4563 660956
SGTC_3142 9086498 49.47 µM -1.61774449416586 0.154379969258771 no 2993 0.0528588364070619 4415 25236367
SGTC_928 2764-0428 58.7 µM -1.6177885729948 0.154373968394904 no 2994 0.0528540849240325 4566 662578
SGTC_624 k048-0052 28 µM -1.61824419710813 0.154311949052798 no 2995 0.052804990712996 4546 6835531
SGTC_1026 k007-1105 30.6 µM -1.62676429789385 0.153155231880305 no 2996 0.0518935834598105 4520 7066794
SGTC_2340 7987427 183.45 µM -1.63037907720152 0.152666218104111 no 2997 0.0515107019454704 4552 2239331
SGTC_530 4358-1714 28 µM -1.63429965594317 0.152137007406051 no 2998 0.0510979729513165 4546 1564641
SGTC_2369 9071472 200 µM -1.63431235725226 0.1521352949298 no 2999 0.0510966401426817 4575 17296037
SGTC_902 1120-0002 2.07 µM -1.63671172418201 0.151812025675004 no 3000 0.0508453590375668 4544 3280475
SGTC_925 2064-1272 59.6 µM -1.63673319349888 0.151809135152952 no 3001 0.0508431150463877 4540 6815817
SGTC_2040 5100729 123 µM -1.63780189444502 0.1516652967892 no 3002 0.0507315131366268 4598 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1689 st020265 53.493 µM -1.64012251259412 0.151353272655309 no 3003 0.0504898482100908 4552 5758320 YPR016C TIF6
SGTC_784 4579-0127 173 µM -1.64012287735895 0.151353223643584 no 3004 0.0504898102963698 4576 1948547
SGTC_3303 9125618 40.5795 µM -1.64160445379725 0.151154238308949 no 3005 0.050336002030797 4547 22695467
SGTC_467 ro 31-8220 72.8 µM -1.64202654129443 0.151097581087599 no 3006 0.0502922518805409 4555 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1704 st028805 70.8 µM -1.64824336625942 0.150264727392149 no 3007 0.0496513705510498 4617 2876101
SGTC_2630 antimycin a 100 µM -1.64875394181029 0.150196462974986 no 3008 0.0495990271329943 4494 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1272 0839-0021 27 µM -1.65073346948981 0.149931993767253 no 3009 0.0493965052084055 4614 5027250
SGTC_1089 terbinafine 2.25 µM -1.65171503694696 0.149800969459274 no 3010 0.0492963279191445 4571 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1019 4262-0212 3.4 µM -1.66174086644532 0.14846704871509 no 3011 0.048282371693861 4569 4677213
SGTC_1527 coumarin 137 µM -1.66746537093187 0.147708985772488 no 3012 0.047710952325504 4603 323 A hepatotoxic, DNA x-linker.
SGTC_97 0535-0701 19.132 µM -1.67164450731104 0.147157206741689 no 3013 0.0472972214031687 4488 2832013 YGL099W LSG1
SGTC_2970 9090938 41.86 µM -1.67359073450998 0.146900715012123 no 3014 0.0471055303639244 4610 17217104
SGTC_1322 1348-1070 12 µM -1.67439619598674 0.146794651667948 no 3015 0.0470263799646472 4583 6758089
SGTC_1647 st011722 22.4 µM -1.67718706795094 0.146427546511655 no 3016 0.0467529535282036 4580 2854783
SGTC_2321 7390090 138.78 µM -1.67720408544651 0.146425309959899 no 3017 0.0467512902159773 4571 649046
SGTC_278 4092-0821 23.9 µM -1.68535485930266 0.145356717060355 no 3018 0.0459600636594633 4563 877900
SGTC_3253 9135987 49.47 µM -1.69553112984664 0.144029955801892 no 3019 0.0449873550171171 4590 4182430
SGTC_1761 st044296 37 µM -1.7046380646644 0.142849557974485 no 3020 0.0441309737776267 4599 1826700
SGTC_1792 st045773 43.6 µM -1.71468294736832 0.141555191196762 no 3021 0.0432016858457163 4578 2919270
SGTC_940 3232-1287 54.8 µM -1.71496201979034 0.141519344206876 no 3022 0.0431760952552688 4581 1585493 YIL048W NEO1
SGTC_317 4495-0002 170 µM -1.71554903536771 0.141443961845363 no 3023 0.043122306626214 4595 15991618
SGTC_1176 0848-0131 83.3 µM -1.71562927238199 0.141433660220117 no 3024 0.043114958661774 4643 6769040
SGTC_1256 0570-0116 285 µM -1.71599073898893 0.141387257850096 no 3025 0.0430818687269165 4580 410638
SGTC_358 0075-0058 9.45 µM -1.73073686224868 0.139503055030544 no 3026 0.0417493537203571 4557 1069125
SGTC_2846 9008642 19.48 µM -1.73666165919076 0.138750838684443 no 3027 0.041223454535216 4594 2992898
SGTC_2238 6671620 73.2395 µM -1.74597569038685 0.137573916870492 no 3028 0.0404075880490384 4520 729941
SGTC_3071 9117417 49.47 µM -1.74819893718155 0.137293997587862 no 3029 0.0402147927932364 4566 45595590 YGL055W OLE1
SGTC_2859 9028643 45.46 µM -1.75564513956271 0.136359313159946 no 3030 0.0395745097927641 4460 17151580
SGTC_218 alverine citrate 93.75 µM -1.75686609636507 0.136206468997748 no 3031 0.0394703178508937 4651 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -1.7583147268713 0.136025275873483 no 3032 0.0393469866369462 4583 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_723 4182-0001 115 µM -1.75836178290652 0.136019392924206 no 3033 0.0393429857187333 4602 744821 YLR208W SEC13
SGTC_3097 9117246 49.47 µM -1.76075010393411 0.135721033586114 no 3034 0.0391403541687678 4624 16423892
SGTC_894 0960-0238 55.9 µM -1.76295041952327 0.135446557698303 no 3035 0.0389544261138167 4609 6741907 YDL195W SEC31
SGTC_287 k060-0039 29.6 µM -1.77063363337186 0.134491108424299 no 3036 0.0383108226087196 4651 5861974
SGTC_2298 7976326 193.81 µM -1.77213163869698 0.134305363671134 no 3037 0.0381863540474682 4585 2235818
SGTC_1695 st026914 34.495 µM -1.77222642634681 0.134293616432137 no 3038 0.0381784892928985 4618 3289191
SGTC_8 0354-0001 70 µM -1.77476436190356 0.133979346939376 no 3039 0.0379684015340593 4607 4993152
SGTC_1135 dihydrocapsaicin 536.708 nM -1.77713739979086 0.133685954042146 no 3040 0.0377728180280546 4541 107982 A Capsaicinoid.
SGTC_1765 st044815 90.4 µM -1.77792465239722 0.133588718935236 no 3041 0.0377081153612352 4617 645695
SGTC_3086 9117350 49.47 µM -1.78378603024151 0.13286629772923 no 3042 0.0372292202093872 4605 2679265
SGTC_381 3461-2219 42.7 µM -1.78511786775636 0.132702523068368 no 3043 0.0371211001677081 4604 2883159
SGTC_750 4073-0104 132 µM -1.79326701793076 0.13170345916097 no 3044 0.0364651192586179 4313 22330957
SGTC_1142 3253-1408 9.78 µM -1.8044772758052 0.130337611156473 no 3045 0.0355782592058156 4616 256655
SGTC_2676 harmalol 100 µM -1.80793315720465 0.129918532609262 no 3046 0.0353084522398058 4605 5459187 A monoamine oxidase inhibitor
SGTC_2203 7227154 166.4 µM -1.80960196175581 0.129716498852964 no 3047 0.0351787677499086 4643 896304
SGTC_2049 5262831 67.185 µM -1.81177250865557 0.129454047377396 no 3048 0.0350106773003855 4596 763417
SGTC_2295 7971645 200 µM -1.81212783434647 0.129411118275199 no 3049 0.0349832232263145 4657 2978226 YKL099C UTP11
SGTC_54 0159-0055 9 µM -1.81272012950993 0.129339581348928 no 3050 0.0349374990924135 4601 3319099
SGTC_2588 indole-3-carbinol 100 µM -1.81311419047906 0.12929200217168 no 3051 0.0349071054696647 4588 3712 Induces cell cycle arrest.
SGTC_351 caspofungin 25 nM -1.81330793284547 0.129268614041418 no 3052 0.034892170229061 4625 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3277 9138724 49.47 µM -1.81880547682106 0.128606185177846 no 3053 0.0344705562707083 4615 15943418
SGTC_369 0957-0393 4.5 µM -1.81903782117112 0.128578240726465 no 3054 0.0344528300661519 4624 6997992
SGTC_2536 dehydroabietamide 32.04 µM -1.82227194633322 0.128189704500518 no 3055 0.0342068663292538 4642 3983547
SGTC_56 0957-0365 83.25 µM -1.82516565860606 0.127842756072742 no 3056 0.0339880171915814 4583 6752360
SGTC_2196 6573537 42.6665 µM -1.83094272156838 0.127152054702137 no 3057 0.0335545464255671 4667 2903087
SGTC_2513 baicalein 25.65 µM -1.83524258282627 0.12663965487263 no 3058 0.0332348771380692 4614 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_522 1273-0010 11.6 µM -1.83844723570823 0.126258703791573 no 3059 0.0329982650761115 4646 5705015
SGTC_2175 5807670 165.306 µM -1.84311062257666 0.125705774533854 no 3060 0.0326564303521429 4612 241186
SGTC_1827 berberine 7.24 µM -1.84391997364054 0.125609983553841 no 3061 0.0325974018758823 4566 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2597 laccaic acid a 100 µM -1.84579767322363 0.125387944061307 no 3062 0.0324607942924437 4595 5491415 A textile dye.
SGTC_609 0986-0026 86.3 µM -1.84662818594616 0.125289822702012 no 3063 0.0324005231336873 4642 2848610
SGTC_705 1124-0212 310 µM -1.84750017545367 0.12518685874988 no 3064 0.0323373413586092 4623 9554485
SGTC_2165 5727197 32.143 µM -1.85035420196554 0.124850270400071 no 3065 0.0321312576372849 4649 1361712
SGTC_471 1-acyl-paf 4 µM -1.85067357471232 0.124812644692492 no 3066 0.0321082639535621 4625 16759367
SGTC_1615 st002656 86.5 µM -1.85123379425034 0.124746663660196 no 3067 0.0320679629864471 4639 1584458
SGTC_3249 9135183 49.47 µM -1.85142501988896 0.124724147240416 no 3068 0.0320542161974603 4594 4902779
SGTC_3265 9137266 49.47 µM -1.85381944844519 0.124442448706796 no 3069 0.0318824975513093 4630 17224265
SGTC_1920 st075728 45.7 µM -1.85398962855618 0.124422444388779 no 3070 0.0318703219043799 4621 3400306
SGTC_105 0111-0055 734.78 µM -1.85642727346862 0.124136151065019 no 3071 0.0316963401340751 4644 5179370
SGTC_3083 9117465 49.47 µM -1.86166585618127 0.12352245717 no 3072 0.0313251020933324 4600 16420915
SGTC_1400 3771-8998 51.5 µM -1.86266890119778 0.12340519441222 no 3073 0.0312544319229303 4637 670767
SGTC_1559 coumarin 343 70.1 µM -1.86705012175786 0.122893914370247 no 3074 0.0309472944073114 4679 108770 A hepatotoxic, DNA x-linker.
SGTC_2341 7987486 176.74 µM -1.86760762559267 0.122828961424104 no 3075 0.0309083913703073 4663 1258686
SGTC_1526 st051518 75 µM -1.86796116886084 0.12278778373193 no 3076 0.0308837418342354 4619 673993
SGTC_2114 5491910 81.25 µM -1.87001302161474 0.122548992638666 no 3077 0.0307410048066406 4646 2849228
SGTC_535 2293-4129 48.2 µM -1.87754316949447 0.121675439768697 no 3078 0.0302218432168294 4637 396118 YIL048W NEO1
SGTC_2675 theaflavin digallate 100 µM -1.87959552836893 0.121438111656849 no 3079 0.0300816115816499 4607 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_474 dl-dihydrosphingosine 5 µM -1.87974252695512 0.121421125716021 no 3080 0.0300715883394988 4623 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2741 miltefosine 3.04 µM -1.88252050837789 0.121100439178788 no 3081 0.029882689009859 4697 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2598 perillyl alcohol 100 µM -1.88468425741442 0.120851071927012 no 3082 0.0297362395102267 4638 10819 An apoptosis inducer.
SGTC_571 k831-0106 44.2 µM -1.88503557529428 0.120810617450626 no 3083 0.0297125174724032 4555 4783639
SGTC_10 0279-0212 42.575 µM -1.88551559776689 0.120755357968641 no 3084 0.029680130301213 4677 39851 YBR002C RER2
SGTC_3044 9093193 49.47 µM -1.88847805810216 0.120414717599515 no 3085 0.0294809004308971 4639 25236277
SGTC_1190 1486-1332 13 µM -1.88994999253751 0.12024571820245 no 3086 0.0293823242519999 4671 4150046
SGTC_1220 1838-0075 193 µM -1.89141984761524 0.120077124368364 no 3087 0.0292841605951772 4592 5529645
SGTC_1210 3013-0140 750 nM -1.89410627711648 0.119769418866829 no 3088 0.029105452359768 4679 905973
SGTC_2015 5119600 184 µM -1.90076916718408 0.11900864767802 no 3089 0.0286661271500651 4628 2828786
SGTC_3173 9105693 49.47 µM -1.90404344782034 0.1186360421599 no 3090 0.0284522629513252 4637 17096658
SGTC_66 0109-0187 42.4 µM -1.90619309607583 0.118391865861673 no 3091 0.0283125788207071 4496 759417
SGTC_979 1426-2828 121 µM -1.9076343136889 0.118228358519805 no 3092 0.0282192484701251 4695 747872
SGTC_1399 3562-5772 25 µM -1.91111170247414 0.117834503443797 no 3093 0.0279951137949014 4657 23847490
SGTC_1862 st057513 3.81 µM -1.91218844667539 0.117712737985106 no 3094 0.0279260137258751 4665 5393163
SGTC_829 1635-0120 117 µM -1.91574241953749 0.117311463037285 no 3095 0.0276989450742868 4642 285054
SGTC_516 3992-2719 87.3 µM -1.91666808123933 0.117207106867909 no 3096 0.0276400563804798 4561 5350887 YDR037W KRS1
SGTC_1050 3232-1156 69.3 µM -1.91967396655386 0.116868686417488 no 3097 0.027449547301056 4637 700529
SGTC_732 3970-1727 52.7 µM -1.92290383473202 0.116505821231803 no 3098 0.0272460640452508 4695 1275699
SGTC_1500 4488-1866 171 µM -1.92333629026254 0.116457296985805 no 3099 0.0272189148989544 4695 2900003
SGTC_2689 tacrolimus 100 µM -1.92612532970482 0.116144693470116 no 3100 0.0270443632766787 4640 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1625 st003711 30.1 µM -1.92895652034073 0.115827975113167 no 3101 0.0268681300998631 4657 24207034 YER133W GLC7
SGTC_2776 terbinafine 19.92 µM -1.9292480127264 0.115795401431508 no 3102 0.0268500401309073 4655 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1789 tunicamycin 25 nM -1.93029741089972 0.115678187188192 no 3103 0.026784998838063 4597 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_891 0929-0073 133 µM -1.93034069055539 0.115673354806627 no 3104 0.0267823192091304 4679 5603632
SGTC_2019 4016004 108 µM -1.9350255427263 0.1151511161273 no 3105 0.0264935806629996 4653 45595336
SGTC_2210 7115885 190.385 µM -1.93836813092306 0.114779530982966 no 3106 0.0262891628251995 4731 2927039
SGTC_2784 7567673 72.73 µM -1.93946409933843 0.114657881494464 no 3107 0.02622242596659 4599 3471247
SGTC_2269 7935389 174.42 µM -1.94202644623492 0.114373826095287 no 3108 0.0260669494050446 4675 97605
SGTC_3289 9119912 71.43 µM -1.94763175350451 0.113754183398603 no 3109 0.0257295207315872 4651 17014829
SGTC_3090 9117696 49.47 µM -1.94961877015326 0.113535102708754 no 3110 0.0256107872485785 4659 7923821
SGTC_2366 9070441 60.58 µM -1.95271373341665 0.113194463685258 no 3111 0.0254267627245541 4644 6837235
SGTC_540 1187-0821 17.3 µM -1.95312492121628 0.113149262308574 no 3112 0.0254023973126763 4623 847520
SGTC_2335 9018011 154.17 µM -1.95795569385426 0.112619185583954 no 3113 0.0251176059173769 4659 6458208
SGTC_1343 1487-0095 224 µM -1.95801334058029 0.112612870782402 no 3114 0.0251142236603806 4657 4560101 YGL055W OLE1
SGTC_1885 st057546 99.9 µM -1.96001405544274 0.112393862932497 no 3115 0.0249970737461882 4687 702008
SGTC_452 diindolylmethane 8 µM -1.96341493960667 0.112022284434404 no 3116 0.0247989896478573 4659 3071 Inhibits expression of several cancer promoting factors.
SGTC_2866 9034245 58.44 µM -1.9769659299612 0.110550435001309 no 3117 0.0240227407196745 4702 6462273
SGTC_653 0203-0016 55.2 µM -1.97872782287034 0.110360088970075 no 3118 0.0239233293254822 4715 295302
SGTC_1849 st056239 19.2 µM -1.98351236430588 0.109844377118627 no 3119 0.0236551136785942 4669 5393181
SGTC_1356 1502-0781 85.8 µM -1.98929534144291 0.10922335833626 no 3120 0.0233343067919281 4701 567702
SGTC_2999 9069765 71.4286 µM -1.99469914212563 0.108645341997263 no 3121 0.0230378515099213 4638 2097066
SGTC_1260 0700-1617 7.75 µM -2.00107336271217 0.107966357062425 no 3122 0.0226922422279505 4645 2853078
SGTC_2802 7925815 54.55 µM -2.00277938399787 0.107785150341431 no 3123 0.0226004868193694 4666 1262923
SGTC_1962 st076595 64.5 µM -2.00655063200707 0.107385361164572 no 3124 0.0223987662093922 4651 279619
SGTC_1676 st018489 23.4 µM -2.00878518830811 0.107148981239544 no 3125 0.0222799598610267 4640 3696235
SGTC_1374 2889-5571 141 µM -2.01114335587787 0.106899932420516 no 3126 0.0221551584045243 4684 2853281
SGTC_517 1365-0151 113 µM -2.01176495086101 0.106834354656665 no 3127 0.0221223601158846 4658 768657
SGTC_477 mead ethanolamide 10 µM -2.01515044014537 0.106477697827886 no 3128 0.0219444442634733 4712 16061185
SGTC_2038 4100038 30.985 µM -2.01971410508993 0.105998283319674 no 3129 0.0217065255823682 4655 3596803
SGTC_2008 4012253 172 µM -2.01990363257273 0.10597840718317 no 3130 0.0216966922135812 4675 603940
SGTC_3332 9141069 11.198 µM -2.02332409930547 0.105620158611636 no 3131 0.02151987191538 4643 17332883
SGTC_1811 st050069 61.5 µM -2.03779971849529 0.104113723691722 no 3132 0.0207849832736806 4689 3877702
SGTC_3040 9091894 49.47 µM -2.04155988855833 0.103724975063251 no 3133 0.0205976037791379 4638 25236966
SGTC_1637 st007924 17.4 µM -2.04317230249548 0.103558597170706 no 3134 0.020517692272836 4639 683336
SGTC_652 0437-0092 114 µM -2.0443755888893 0.103434561600968 no 3135 0.0204582284896127 4673 3091274
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -2.0466360163593 0.10320184684288 no 3136 0.0203469179030865 4704 390807
SGTC_1645 Cervolide 78 µM -2.04702185737101 0.103162161888021 no 3137 0.0203279692559831 4713 23173 A fragrance.
SGTC_738 1315-0003 72.4 µM -2.04863895267665 0.102995959130449 no 3138 0.0202487163620553 4692 6251474
SGTC_945 3381-0768 11.3 µM -2.05508287914861 0.102335593410906 no 3139 0.019935500143655 4683 1126236 YIL048W NEO1
SGTC_1462 k081-0014 26.5 µM -2.06785997844705 0.101035328226011 no 3140 0.0193265958659457 4145 3270634
SGTC_2351 9026858 72.31 µM -2.07169385186267 0.100647531938327 no 3141 0.0191470005373345 4629 1409300
SGTC_2886 9058944 51.95 µM -2.07280006921808 0.100535840142354 no 3142 0.0190954450016901 4698 4949929
SGTC_3314 9135860 59.4275 µM -2.08357935399866 0.0994522153698014 no 3143 0.0185992233073808 4681 25252478
SGTC_3101 9120531 49.47 µM -2.08564533460503 0.0992455041425569 no 3144 0.0185053807917748 4663 24824904
SGTC_2282 7944268 200 µM -2.09297925824804 0.0985142472084242 no 3145 0.0181755030818548 4679 2970414
SGTC_1032 k061-1018 98.7 µM -2.09703471926017 0.0981115796243082 no 3146 0.0179952510050917 4724 4005393
SGTC_1437 4092-1038 11.6 µM -2.10329428188079 0.097492435373266 no 3147 0.0177200264955173 4742 3977136
SGTC_1341 1486-1360 280 µM -2.10740562676065 0.0970873372840177 no 3148 0.0175412171472842 4710 3976547
SGTC_2176 5809774 33.9695 µM -2.11175701740509 0.0966599342630883 no 3149 0.0173536478668085 4660 2870539
SGTC_3087 9117406 49.47 µM -2.11368221026945 0.096471279253387 no 3150 0.017271209466682 4691 42546093
SGTC_604 1000-0114 314 µM -2.11537246868495 0.0963058692769865 no 3151 0.0171991071878654 4726 1572745
SGTC_167 3672-0051 66.205 µM -2.11544705113143 0.0962985753866302 no 3152 0.0171959316169911 4651 3237971
SGTC_2146 5545642 200 µM -2.11767589670739 0.0960807897717959 no 3153 0.0171012627679845 4693 825326
SGTC_2262 9014885 67.46 µM -2.11837702643215 0.0960123557109267 no 3154 0.0170715749611009 4738 6457424
SGTC_967 1306-0166 352 µM -2.12891984085899 0.0949876378996246 no 3155 0.0166304464696122 4706 4437607
SGTC_1271 0832-2808 169 µM -2.12965408027945 0.0949165741080906 no 3156 0.0166000913488384 4730 3663794
SGTC_3100 9120536 49.47 µM -2.13118977293713 0.0947680678468135 no 3157 0.016536755606299 4651 16421196
SGTC_1945 st075991 56.6 µM -2.1334089252374 0.0945537715066154 no 3158 0.0164455977678283 4699 1084980
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -2.13558030763165 0.0943444341445999 no 3159 0.0163568189731021 4699 2374 Ca(2+)-ATPase inhibitor.
SGTC_1169 aniline yellow 25.8 µM -2.14476557925645 0.0934626862115916 no 3160 0.0159857972888895 4691 6051 A DNA damaging agent.
SGTC_3047 9092122 49.47 µM -2.14507792379738 0.0934328098067098 no 3161 0.0159733085956054 4691 17173831
SGTC_2908 7930301 100 µM -2.14599567660369 0.0933450656583787 no 3162 0.0159366618146316 4671 2223178
SGTC_1609 st001574 46.4 µM -2.15059465553804 0.0929062850158045 no 3163 0.0157541037692177 4707 3960012
SGTC_1747 st037496 66.6 µM -2.15433734443572 0.09255032845608 no 3164 0.0156068631321239 4659 723305
SGTC_2697 mebhydrolin 72.4 µM -2.15637190307778 0.0923572511365489 no 3165 0.0155273184017748 4701 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2570 licareol 100 µM -2.15809952259111 0.0921935361485703 no 3166 0.0154600474381358 4676 443158
SGTC_1325 1431-0015 227 µM -2.16330438791421 0.0917016043826419 no 3167 0.0152588879142769 4715 1103340
SGTC_1020 4335-0961 93.3 µM -2.16582829026103 0.0914637620253101 no 3168 0.0151621553346784 4693 669075
SGTC_2096 5468907 200 µM -2.17108818678937 0.0909695605089306 no 3169 0.014962253423408 4736 759785
SGTC_2205 7238770 200 µM -2.17139605036823 0.0909406962053956 no 3170 0.0149506236082622 4733 279867
SGTC_3287 9117173 37.0625 µM -2.18088100633445 0.0900547431705292 no 3171 0.0145961094576884 4742 2789709
SGTC_672 1441-0018 53.7 µM -2.18191574284345 0.0899584817431991 no 3172 0.0145578758736472 4746 251141
SGTC_3246 9135460 32.98 µM -2.18395298725249 0.0897691806252942 no 3173 0.0144828514063703 4734 41446951
SGTC_875 0709-0210 25.7 µM -2.18671446207257 0.0895130568404049 no 3174 0.0143816875954294 4716 6251364
SGTC_3254 9136651 49.47 µM -2.19461593820397 0.0887832061864454 no 3175 0.0140955796380412 4702 16454030
SGTC_673 1082-0474 110 µM -2.19621480870903 0.0886360608579147 no 3176 0.0140382859611169 4704 3098046
SGTC_468 gf-109203x 121 µM -2.19999972985381 0.0882884556208971 no 3177 0.0139034570968275 4763 2396 A protein kinase C inhibitor.
SGTC_1993 st073995 70.8 µM -2.20122636368001 0.0881760204620971 no 3178 0.0138600014073203 4714 3098394
SGTC_1991 st073000 8.92 µM -2.2082218310441 0.0875368444387166 no 3179 0.0136144066461794 4731 4301969 YIL048W NEO1
SGTC_1230 0170-0365 3.77 µM -2.21348823512235 0.0870579389720866 no 3180 0.0134320017278853 4723 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1351 1496-0003 46.5 µM -2.21471092475571 0.0869470329492193 no 3181 0.0133899562615924 4736 3891978
SGTC_407 eburnamonine 100 µM -2.21532725325815 0.086891167910732 no 3182 0.0133688052686747 4634 3195
SGTC_2142 5622915 118.518 µM -2.22520147494506 0.085999804970859 no 3183 0.013033857944735 4735 5322196
SGTC_1838 st055369 84.5 µM -2.22846339112952 0.0857068547466857 no 3184 0.0129248149809445 4719 676036
SGTC_3127 9126946 49.47 µM -2.2328749806476 0.0853118425132681 no 3185 0.0127785949540315 4687 27243249
SGTC_1246 0422-0085 105 µM -2.23501529686495 0.0851206913879738 no 3186 0.0127081722543952 4702 264295
SGTC_1223 0764-0573 147 µM -2.24270152108048 0.0844368822074382 no 3187 0.0124580342460956 4733 1609797
SGTC_1564 D-Arginine 115 µM -2.24457399913661 0.084270922212258 no 3188 0.0123977467420127 4708 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1524 corynanthine 62.1 µM -2.25089809926458 0.0837122191083529 no 3189 0.0121959960822309 4747 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1405 3909-7894 12 µM -2.25194339530392 0.0836201409516774 no 3190 0.0121629246651539 4733 7104060
SGTC_2313 7726885 200 µM -2.25504451961327 0.0833474165343718 no 3191 0.0120652672492673 4714 726423
SGTC_2379 9035213 200 µM -2.25626786074944 0.0832400154602269 no 3192 0.012026930447049 4726 646551
SGTC_161 4065-0411 162.148 µM -2.26006205885359 0.0829075723593498 no 3193 0.011908699747454 4720 1906281 YLR208W SEC13
SGTC_2890 9046729 58.44 µM -2.26010444194796 0.0829038644525158 no 3194 0.0119073847655784 4724 903329
SGTC_1972 st070201 17.4 µM -2.26428711655878 0.0825385543429686 no 3195 0.0117782307286964 4737 2829099
SGTC_1151 3909-8316 15.3 µM -2.2718968350548 0.0818770398080831 no 3196 0.0115463710583271 4749 800431
SGTC_2783 7738165 71.43 µM -2.27493806444767 0.0816137854374376 no 3197 0.0114548227547439 4710 17201110
SGTC_1990 st072050 59.8 µM -2.28225760532939 0.0809828095742483 no 3198 0.0112370679541196 4741 17233948
SGTC_599 1935-0052 86.5 µM -2.29204789171896 0.0801446101618046 no 3199 0.0109514398854607 4742 9557311
SGTC_2255 7941087 197.44 µM -2.29670373377543 0.0797483066214355 no 3200 0.0108178381568948 4751 935561
SGTC_1461 k072-0203 53.8 µM -2.31918419900078 0.0778556114929854 no 3201 0.0101925254276591 4603 5418714
SGTC_939 1165-0479 45.3 µM -2.32352904321615 0.0774937701186354 no 3202 0.0100753746479113 4719 1377347
SGTC_2550 chrysin dimethyl ether 71.87 µM -2.33039351900662 0.0769246969456578 no 3203 0.00989268100122092 4693 88881 An O-methylated flavonoid and antioxidant.
SGTC_596 1155-0152 116 µM -2.33103980108346 0.0768712834437018 no 3204 0.00987563053531605 4756 280313
SGTC_2190 6049624 200 µM -2.33280717780787 0.0767253584216122 no 3205 0.00982913389244436 4710 2265554
SGTC_74 000s-0487 160.283 µM -2.33300161962453 0.0767093170316697 no 3206 0.00982403015561968 4667 677548
SGTC_1718 roemerine 11.9335 µM -2.34134955660325 0.0760230174250549 no 3207 0.00960708398131846 4405 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1017 4239-0030 168 µM -2.35004511893895 0.0753131201187468 no 3208 0.00938556777583329 4741 1149593
SGTC_3056 9094900 49.47 µM -2.35463322165167 0.0749405940984704 no 3209 0.00927049813444394 4725 25236784
SGTC_1390 3413-2614 145 µM -2.35567135945419 0.074856498947814 no 3210 0.00924463355799776 4742 3421432
SGTC_751 0833-0568 350 µM -2.35765561156676 0.0746959634137921 no 3211 0.00919537278057788 4740 6954252
SGTC_2818 7996756 12.99 µM -2.36321680163355 0.0742474363996874 no 3212 0.00905853375758373 4738 2241621
SGTC_42 0133-0086 60.653 µM -2.36386249096627 0.0741954931324375 no 3213 0.00904276201025481 4686 162923 Model of phenazepam hydroxylation.
SGTC_907 3448-6986 75.5 µM -2.36489449347747 0.0741125300671375 no 3214 0.00901760402823754 4737 590582
SGTC_1989 st071868 50.2 µM -2.36956301252413 0.0737381112212552 no 3215 0.00890456005996092 4749 16414057
SGTC_1463 k081-0032 34.1 µM -2.37529538581691 0.0732803501568311 no 3216 0.00876745567598869 4303 977755
SGTC_313 3474-0040 5.03 µM -2.37612383030811 0.0732143745579819 no 3217 0.00874779514025764 4749 1043375 YIL048W NEO1
SGTC_396 dithiazanine 1.25 µM -2.37839994774513 0.0730333432439236 no 3218 0.00869397747206894 4736 10578 An antihelmenthic.
SGTC_2172 5754775 163.918 µM -2.37977467611693 0.0729241700906137 no 3219 0.00866161352502573 4734 2263357
SGTC_2066 5222451 176 µM -2.38189549378848 0.0727559918191923 no 3220 0.00861189232120958 4716 2281147
SGTC_2365 9042475 200 µM -2.38582989264615 0.0724447854687252 no 3221 0.00852031559138761 4738 6464479
SGTC_400 oxethazaine 37.5 µM -2.39934878956503 0.0713832256571154 no 3222 0.00821213087767133 4769 4621 A local anesthetic.
SGTC_1178 0988-0033 191 µM -2.41127990908092 0.070456299329561 no 3223 0.00794832153840039 4765 5392207
SGTC_1171 0368-0077 21.4 µM -2.41503387325691 0.0701665764780955 no 3224 0.00786687320424758 4761 3239779
SGTC_1912 st060209 90.8 µM -2.42121078324175 0.0696918514856462 no 3225 0.00773445239527785 4729 688787
SGTC_1915 st067105 30.6 µM -2.42159476360793 0.0696624225909041 no 3226 0.00772628575806206 4708 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2362 9071156 126 µM -2.4238586526932 0.0694891088050576 no 3227 0.00767829062539382 4733 653133
SGTC_19 0279-0214 38.434 µM -2.43197993225197 0.068870109202143 no 3228 0.00750826963969167 4784 3566274 YBR002C RER2
SGTC_2156 5649887 115 µM -2.4379333836019 0.0684190470029529 no 3229 0.00738574793784737 4766 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_38 0929-0051 58.268 µM -2.44718283199531 0.0677227900060689 no 3230 0.00719888912694601 4732 1379719
SGTC_2661 dactinomycin 12.96 µM -2.45189815824313 0.0673699541495317 no 3231 0.00710524374022535 4776 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1642 st009582 77.7 µM -2.45356650770054 0.0672454566817871 no 3232 0.00707236901383531 4755 6739311
SGTC_1436 4092-1007 8.32 µM -2.45784415344212 0.06692705805011 no 3233 0.00698869076746408 4770 2881121
SGTC_1140 3229-1848 2.98 µM -2.47299645356519 0.0658086002493794 no 3234 0.00669927362912442 4750 2849525
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -2.4897828427903 0.0645864976959065 no 3235 0.0063910583812894 4776 688664
SGTC_2763 lisinopril 49.32 µM -2.49082922564655 0.0645109053333188 no 3236 0.00637226801646567 4720 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_455 paf C-16 10 µM -2.49754065891745 0.0640276938098048 no 3237 0.00625290614545372 4744 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_115 0527-0192 112.043 µM -2.51429828590046 0.0628334597194199 no 3238 0.00596347546703883 4730 4233931
SGTC_316 k060-0003 58.6 µM -2.52659981986388 0.0619678903513833 no 3239 0.00575863268899364 4783 6152314
SGTC_3231 9132313 49.47 µM -2.52737507789335 0.0619136543306002 no 3240 0.00574593493999611 4770 4905967
SGTC_2861 9024595 19.48 µM -2.53466094868005 0.0614057529627062 no 3241 0.00562781039012927 4759 16482810
SGTC_4 0960-0234 25.671 µM -2.53919254372909 0.0610914988254651 no 3242 0.00555543279986839 4710 6821112
SGTC_124 0136-0217 7.121 µM -2.54959780427057 0.0603746787918734 no 3243 0.00539236280279146 4779 3976905
SGTC_469 w7 172 µM -2.55435163089823 0.0600493852355968 no 3244 0.00531928794561892 4791 45115570 A P450 inhibitor.
SGTC_1938 st074717 56.4 µM -2.55560782604682 0.0599636563071171 no 3245 0.0053001256643068 4723 17250979
SGTC_3213 9129884 49.47 µM -2.56810952090438 0.0591156942506143 no 3246 0.00511274217431716 4738 17190742
SGTC_1310 1188-0297 994 nM -2.57468448762927 0.0586735184468798 no 3247 0.00501657817165319 4718 1588352
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -2.57966547678373 0.0583402715621726 no 3248 0.00494480321440891 4777 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2553 4-methylesculetin 85.09 µM -2.58262108967681 0.0581432338545351 no 3249 0.00490264731990014 4764 5319502
SGTC_1671 st016596 74.5 µM -2.59758375675991 0.057153750992413 no 3250 0.00469411105611633 4793 2829167
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -2.60186435530919 0.0568731264440555 no 3251 0.00463592583403673 4769 803109
SGTC_601 0986-0029 62.9 µM -2.60301473954919 0.0567978956288142 no 3252 0.00462039903853549 4744 24747981
SGTC_1754 st042065 16.137 µM -2.60411619755291 0.0567259378768271 no 3253 0.00460557610976096 4625 1126236 YIL048W NEO1
SGTC_1531 st059297 52.4 µM -2.61205227568704 0.0562095981026223 no 3254 0.00450002455603186 4775 7566702
SGTC_1251 0490-5699 265 µM -2.61912554156661 0.0557525246663401 no 3255 0.00440777489934815 4763 3883818
SGTC_1388 3346-4487 254 µM -2.62161067857111 0.0555926334940892 no 3256 0.00437576703831728 4780 3345614
SGTC_1481 3346-2004 36 µM -2.62678105751167 0.0552611365997162 no 3257 0.00430983876999435 4797 2770522
SGTC_2649 anisomycin 9.56 µM -2.63904212099986 0.0544812636718631 no 3258 0.00415703250808884 4784 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1099 5-nonyloxytryptamine 2.85 µM -2.65707103589224 0.0533503629122129 no 3259 0.00394114160552437 4779 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_314 1671-0008 2.74 µM -2.65874546974455 0.0532462818410943 no 3260 0.003921609600107 4688 3913060
SGTC_11 0438-0307 1.3 µM -2.66991961285953 0.0525558240471189 no 3261 0.00379347042387342 4766 4011476
SGTC_3166 9102297 49.47 µM -2.67381599815452 0.0523167415871165 no 3262 0.00374967930112193 4764 25237072
SGTC_2310 7668677 200 µM -2.68823971464702 0.0514392088871498 no 3263 0.0035914905367024 4728 2197143
SGTC_3179 9107801 49.47 µM -2.69179961892273 0.0512244370553858 no 3264 0.00355338152466636 4775 4818259
SGTC_3329 9141233 27.5565 µM -2.69204857991669 0.0512094437750068 no 3265 0.00355073001268092 4750 4909101 YNL103W MET4
SGTC_2669 eugenol 100 µM -2.70451884548436 0.0504628991426553 no 3266 0.00342016947625252 4801 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2779 methotrexate 400 µM -2.73003358253956 0.0489624662579158 no 3267 0.003166393705095 4760 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -2.73445446945284 0.0487061495558084 no 3268 0.00312418680838228 4784 688662
SGTC_2964 9083345 53.42 µM -2.7388472629949 0.0484525251390474 no 3269 0.00308275046528382 4759 17741579
SGTC_2993 9054257 71.4286 µM -2.73932715138042 0.0484248821845947 no 3270 0.00307825389156208 4744 6470217 YGL055W OLE1
SGTC_2543 pimpinellin 60.67 µM -2.74589058588191 0.0480480739386176 no 3271 0.00301734429343343 4728 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3349 9149703 23.001 µM -2.74717775885458 0.0479744529921151 no 3272 0.00300552727731107 4778 4910494
SGTC_3206 9114350 49.47 µM -2.74833547842231 0.047908313394597 no 3273 0.00299493435497168 4703 17087243
SGTC_2985 9022375 71.43 µM -2.76730352851729 0.0468350439032875 no 3274 0.00282610515552471 4762 4939335
SGTC_49 0717-0965 32.132 µM -2.77712390741572 0.0462870027601496 no 3275 0.00274211338151189 4785 5889349 YGL099W LSG1
SGTC_327 1273-0057 3.96 µM -2.79305408518336 0.0454089576194683 no 3276 0.00261064805865619 4762 3108138
SGTC_911 3456-4043 236 µM -2.81934404350434 0.0439892402432051 no 3277 0.00240609545528526 4761 914281
SGTC_2445 5742597 35.57 µM -2.83438507267187 0.0431932258686191 no 3278 0.00229569847562787 4779 1774255
SGTC_2954 9074818 52.69 µM -2.84304098264283 0.0427404300508681 no 3279 0.00223426620513049 4776 16648742
SGTC_436 n,n-dimethylsphingosine 3.3 µM -2.84476757066597 0.0426505718301158 no 3280 0.00222219202765916 4777 5282309
SGTC_1231 0242-0792 125 µM -2.8477295406826 0.0424967754351446 no 3281 0.00220161637402569 4777 3707635
SGTC_3346 9158254 43.5805 µM -2.8517527285738 0.0422885953592078 no 3282 0.00217394540324954 4775 17639500
SGTC_1360 1598-0022 39.8 µM -2.85236484269439 0.0422569939189718 no 3283 0.00216976310608497 4796 761525
SGTC_1522 st012842 45.6 µM -2.85935399207863 0.0418975199985272 no 3284 0.00212252392466854 4714 3491067 YOR116C RPO31
SGTC_2413 inermin 26.06 µM -2.88259484090325 0.0407199405756532 no 3285 0.00197207191829941 4775 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_116 0155-0182 31.788 µM -2.90136786882677 0.0397884731532012 no 3286 0.00185768714753033 4744 771486
SGTC_2628 lathosterol 100 µM -2.90455948145366 0.0396318501837387 no 3287 0.00183885157640457 4775 6710616
SGTC_3291 9121177 71.43 µM -2.91573060668526 0.0390875905444373 no 3288 0.00177428377617543 4772 17015612
SGTC_2257 7960413 200 µM -2.94373792032143 0.0377497841534409 no 3289 0.00162137235226161 4792 2974689 YIL048W NEO1
SGTC_3232 9132874 49.47 µM -2.95054836244999 0.0374301870330815 no 3290 0.00158605189603944 4782 3784940
SGTC_3052 9092717 49.47 µM -2.97302726759779 0.0363909597500938 no 3291 0.00147439126814211 4779 25237534
SGTC_394 menadione 8.33 µM -3.0112949995401 0.0346761875786909 no 3292 0.00130067994778201 4791 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2965 9082772 38.63 µM -3.01315068469611 0.0345947508843741 no 3293 0.00129275251963923 4782 16459634
SGTC_72 0744-0168 198.391 µM -3.03052086600146 0.0338400530107246 no 3294 0.00122066158804503 4759 677577
SGTC_2187 6125751 200 µM -3.03197779852831 0.0337773728081717 no 3295 0.00121478536374793 4791 874498
SGTC_3129 9127257 49.47 µM -3.08671410984005 0.0314908352501783 no 3296 0.00101191068888523 4776 837894
SGTC_2626 ethyl orsellinate 100 µM -3.12901655460624 0.0298126877750333 no 3297 0.000876962132412305 4773 75653 A natural product.
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -3.13880123835895 0.0294352785303902 no 3298 0.000848202356811736 4787 1377
SGTC_2385 9074692 200 µM -3.1736691208447 0.0281224876637643 no 3299 0.000752625898932027 4794 17046906
SGTC_3248 9135562 49.47 µM -3.18816627060102 0.0275911975043353 no 3300 0.000715890899637452 4794 17650701
SGTC_3218 9131285 49.47 µM -3.19515776547709 0.0273379797309438 no 3301 0.000698772110671809 4774 17156417
SGTC_2796 7949634 45.45 µM -3.24526532865661 0.025579341984784 no 3302 0.000586706176129211 4787 2971588
SGTC_3200 9114385 49.47 µM -3.27445122803172 0.0245993694039943 no 3303 0.000529337061967864 4777 17018030 YLR208W SEC13
SGTC_1402 3909-7673 35.9 µM -3.2855809409882 0.0242340591641527 no 3304 0.000508861486631614 4787 5328014
SGTC_3162 9099653 49.47 µM -3.2905611041835 0.0240720769706813 no 3305 0.000499938916638753 4799 25237511
SGTC_2148 5546263 113.568 µM -3.29716204037801 0.0238587810857395 no 3306 0.000488335679932617 4796 792097
SGTC_2657 nystatin 74.44 µM -3.32924181394902 0.0228446789721924 no 3307 0.000435413807060761 4805 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1303 1160-0052 261 µM -3.38817119308782 0.021076354509096 no 3308 0.000351801669112473 4793 3562476
SGTC_416 estradiol valerate 100 µM -3.3914020810394 0.020982848661139 no 3309 0.000347680027254211 4803 13791 A steroid.
SGTC_1096 rimcazole 32.2 µM -3.39823873159954 0.020786144636541 no 3310 0.000339106044347632 4803 18528119 A dopamine reuptake inhibitor.
SGTC_121 0557-0495 61.343 µM -3.40762473324736 0.0205186356542856 no 3311 0.000327654749779084 4792 3104427
SGTC_3004 9076122 71.4286 µM -3.41104376275481 0.0204219179237306 no 3312 0.000323573518797919 4804 44782551
SGTC_741 4582-0002 126 µM -3.43991066017795 0.0196206255230063 no 3313 0.000290953119170603 4802 2912688
SGTC_3106 9121286 49.47 µM -3.45909450014733 0.0191030148076854 no 3314 0.000270997353730649 4794 15943471
SGTC_2997 9067075 71.4286 µM -3.46402618605648 0.0189718416051375 no 3315 0.000266077352553322 4791 27209819
SGTC_1861 st057647 17.4 µM -3.488216716019 0.0183394622040606 no 3316 0.000243126891477808 4799 688668
SGTC_1802 st050112 57.9 µM -3.52702860226136 0.017362392356058 no 3317 0.000210125681189097 4800 4662563
SGTC_2870 9038528 12.99 µM -3.54503007104901 0.0169245241225617 no 3318 0.000196284148603575 4803 6463316
SGTC_3343 9148379 18.9835 µM -3.60277052051749 0.0155831975674462 no 3319 0.000157421731709295 4807 1955036
SGTC_438 sphingosine 6.67 µM -3.61336251892022 0.0153473103764452 no 3320 0.000151125824531984 4790 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2432 5630864 12.22 µM -3.68689145011292 0.0137927916102859 no 3321 0.00011350506602478 4801 5714970
SGTC_2888 9058547 12.99 µM -3.6898532248021 0.013733128903618 no 3322 0.000112191737532451 4800 16476514
SGTC_2288 7946289 167.31 µM -3.6975187797361 0.0135797448841608 no 3323 0.000108858558651996 4801 1246052
SGTC_3177 9107506 49.47 µM -3.71237768077217 0.0132866325059036 no 3324 0.000102660648224088 4805 8897194
SGTC_1968 st069590 43.6 µM -3.78772270835221 0.0118830087362927 no 3325 7.60171946382706e-05 4802 6384066
SGTC_399 oxolinic acid 75 µM -3.83115264649761 0.0111338732535823 no 3326 6.37721709725247e-05 4804 4628 A DNA gyrase inhibitor.
SGTC_1475 4092-1048 11.7 µM -3.85198943755932 0.0107892702161453 no 3327 5.85810388923361e-05 4807 2881759
SGTC_2515 chrysin 20.77 µM -3.88815446966343 0.0102131777956466 no 3328 5.0504668830078e-05 4808 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1103 duloxetine 36.1 µM -3.92238747162971 0.00969276787790253 no 3329 4.38379224044329e-05 4807 60835 A selective serotonin reuptake inhibitor.
SGTC_2010 4012422 159 µM -3.94901552007811 0.00930413817574659 no 3330 3.9236632134519e-05 4801 952393
SGTC_1363 1636-0063 10.4 µM -3.99248141022118 0.00869902274882088 no 3331 3.26927301620019e-05 4807 6072185
SGTC_1340 1486-1359 257 µM -4.02406534203208 0.00828124412203795 no 3332 2.86010174850235e-05 4808 4309068
SGTC_3096 9117468 49.47 µM -4.05822391771295 0.00784934160705836 no 3333 2.47236724786936e-05 4809 41316311
SGTC_2827 7993847 71.43 µM -4.07567815033326 0.00763639660450611 no 3334 2.29402204703209e-05 4806 2985692
SGTC_2687 chenodiol 100 µM -4.16079964247163 0.00666915288242329 no 3335 1.5856761069935e-05 4805 5702181 A cholesterol synthesis inhibitor.
SGTC_3081 9117243 49.47 µM -4.20611703326644 0.00619974511208574 no 3336 1.29897867326461e-05 4799 45595589
SGTC_3050 9093513 49.47 µM -4.21980200936675 0.00606386604186298 no 3337 1.22258481862452e-05 4804 25236664
SGTC_2995 9067767 71.4286 µM -4.23681060420871 0.0058986693915185 no 3338 1.13358609258998e-05 4804 11673567
SGTC_3027 9089541 49.47 µM -4.24764399476589 0.00579554207604663 no 3339 1.08015157697521e-05 4807 9943819
SGTC_3017 9080681 49.47 µM -4.27979873208441 0.00549880705102419 no 3340 9.35312004822576e-06 4807 16451914
SGTC_3117 9124945 49.47 µM -4.31283594405394 0.00520806461729305 no 3341 8.05868575310041e-06 4807 17592065
SGTC_2377 9073351 62.6 µM -4.53710632628083 0.00357075737487651 no 3342 2.85156783246059e-06 4806 7337946 YHR072W ERG7
SGTC_432 NS 1619 61.3 µM -4.54820250535871 0.00350331851440799 no 3343 2.70530298404509e-06 4806 4552 A K+/calcium channel activator.
SGTC_1818 st052136 56.3 µM -4.55769314779462 0.00344654753422314 no 3344 2.58592611943969e-06 4793 674169
SGTC_453 enantio-paf c16 10 µM -4.55814177788409 0.00344388449961947 no 3345 2.58040980586463e-06 4624 13871343 A lipid and platelet activating factor
SGTC_3204 9114183 49.47 µM -4.57526464694661 0.00334361603874872 no 3346 2.37809187213434e-06 4799 17027248
SGTC_1242 0402-0103 60.1 µM -4.59710573771297 0.00321953047344027 no 3347 2.14200119584421e-06 4803 432868
SGTC_914 3820-6779 408 µM -4.63625264292202 0.00300745181419371 no 3348 1.7739114869677e-06 4805 2893481
SGTC_3031 9088762 49.47 µM -4.65542107742209 0.00290826912264663 no 3349 1.61659620589075e-06 4810 205253
SGTC_3170 9103054 49.47 µM -4.65809897057585 0.00289465028327593 no 3350 1.59571391250178e-06 4807 16432970
SGTC_3030 9087619 49.47 µM -4.67297293381966 0.00282004778368766 no 3351 1.48435450896068e-06 4809 25236973
SGTC_3094 9117742 49.47 µM -5.17163045551426 0.00113035252006331 no 3352 1.16030086731389e-07 4809 17149698
SGTC_2662 daunorubicin 22.37 µM -5.18604894017933 0.00109962423434138 no 3353 1.07401192153383e-07 4736 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3001 9076041 71.4286 µM -5.26851774123975 0.000938105672302952 yes 3354 6.87648762837309e-08 4810 16004211
SGTC_1250 0485-0349 40.2 µM -6.16417428570689 0.000146036212904193 yes 3355 3.54259365228547e-10 4808 6842794 YDL195W SEC31
SGTC_435 c-PAF 6.7 µM -6.96799756013839 2.22578742901283e-05 yes 3356 1.60741900553091e-12 4809 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase