SGTCid condition conc unit HSP26|YBR072W.score HSP26|YBR072W.strain.pval HSP26|YBR072W.strain.significant HSP26|YBR072W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 8.18339887455634 8.60444642573065e-18 yes 1 1.3797392877661e-16 1 521171 SGTC_615 k087-0205 167 µM 7.80114642170055 2.4513768803824e-16 yes 2 3.06736406495083e-15 1 9642773 SGTC_1403 3909-7815 62.9 µM 4.94192310595743 1.36128632697773e-07 yes 3 3.86778631866341e-07 8 6615483 SGTC_271 rotenone 740 µM 4.8626461715744 2.10404068546498e-07 yes 4 5.79133928473348e-07 9 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1688 st021091 57.6 µM 4.69204401895661 5.25199573079785e-07 yes 5 1.35244454169747e-06 2 3656366 SGTC_1776 st049249 45.9 µM 4.41994154949412 2.1215828595777e-06 yes 6 4.93638005582433e-06 11 1822314 SGTC_466 geldanamycin 89.2 µM 4.38265088642577 2.55356899033029e-06 yes 7 5.86219554927581e-06 4 5288382 HSP90 inhibitor. SGTC_1188 1403-0014 4.57 µM 4.31369822589241 3.58360877954574e-06 yes 8 8.02730285826489e-06 41 9614867 SGTC_1390 3413-2614 145 µM 4.30559137916245 3.72806077141548e-06 yes 9 8.32701124678027e-06 16 3421432 SGTC_2019 4016004 108 µM 4.28420321978936 4.13637598508029e-06 yes 10 9.16976144563583e-06 21 45595336 SGTC_1060 3448-7350 82 µM 4.13173078927554 8.55899791170328e-06 yes 11 1.80020974806503e-05 31 570178 SGTC_2485 5633444 17.78 µM 4.07620341413075 1.10874996501394e-05 yes 12 2.28884887622235e-05 37 5724239 SGTC_513 4245-1575 41.7 µM 4.0589631773311 1.20075169323839e-05 yes 13 2.46455423717005e-05 109 719745 SGTC_652 0437-0092 114 µM 3.9982259857482 1.58618682124654e-05 yes 14 3.19095027930923e-05 14 3091274 SGTC_173 1273-0061 2.693 µM 3.96567583925804 1.8385104253413e-05 yes 15 3.65941368034792e-05 185 2847414 YPL266W DIM1 SGTC_556 4058-0063 51.5 µM 3.92052506397191 2.25221542255558e-05 yes 16 4.41781227048051e-05 26 6615692 SGTC_577 r071-0003 38.6 µM 3.91091159872829 2.35103704518559e-05 yes 17 4.59742119461117e-05 58 4568517 YMR134W ERG29 SGTC_362 0310-0100 9.03 µM 3.8973838883248 2.49707911512888e-05 yes 18 4.86187085898283e-05 36 790235 SGTC_1799 st045822 46.1415 µM 3.87620757426423 2.74308185334993e-05 yes 19 5.30485911945e-05 15 3674992 SGTC_2483 5729050 27.16 µM 3.66847318220926 6.7283609392661e-05 yes 20 0.000122001641201759 32 2865180 SGTC_3340 9146634 11.102 µM 3.362074678954 0.000233115313669202 yes 21 0.00038679599455861 28 4907387 SGTC_3329 9141233 27.5565 µM 3.34467462517622 0.000249441048406455 yes 22 0.000411895760015033 27 4909101 YNL103W MET4 SGTC_1994 st072947 40.9 µM 3.32836634192487 0.000265704508418662 yes 23 0.000436784555218291 37 5286565 YDL195W SEC31 SGTC_893 0958-0369 48.9 µM 3.25572847144418 0.000350873216754271 yes 24 0.000565509291861849 54 6819948 SGTC_2297 7971671 152.32 µM 3.23916044277086 0.000373565011687531 yes 25 0.000599410580499159 55 909016 SGTC_735 3076-0345 636 µM 3.15004245497736 0.000520814092345115 yes 26 0.000816233690582911 74 2888990 SGTC_1912 st060209 90.8 µM 3.13022732552475 0.000560139154461877 yes 27 0.000873355379784002 71 688787 SGTC_1562 morin hydrate 59.1 µM 3.13015614922969 0.000560285231919597 yes 28 0.000873567028186612 52 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1090 efavirenz 20.7 µM 3.12295272793716 0.000575252542389607 yes 29 0.000895232514077037 52 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 3.07200314178729 0.000692131537147884 yes 30 0.00106313743598951 48 688669 SGTC_1284 0929-0043 16 µM 3.0157404142912 0.000846392858820754 yes 31 0.00128176311617569 67 1239883 SGTC_2034 5197015 53.07 µM 3.01121157297367 0.000860093219014111 yes 32 0.00130103738522856 61 780676 SGTC_1768 st044301 37.178 µM 3.003066685146 0.000885246980186557 yes 33 0.00133636929716711 60 3931349 SGTC_231 b-estradiol 524 µM 2.97036487102346 0.00099319760407225 yes 34 0.00148723116132867 30 450 A steroid. SGTC_2204 7233102 200 µM 2.96998195211202 0.000994530311692442 yes 35 0.00148908622628895 29 2172480 SGTC_2201 6605497 169.863 µM 2.946419104897 0.00107976716275592 no 36 0.00160738247487632 39 670741 SGTC_2365 9042475 200 µM 2.92022017469717 0.00118236763632618 no 37 0.0017489208285917 91 6464479 SGTC_2480 5767542 37.17 µM 2.912246884058 0.00121532015715415 no 38 0.00179419446615563 51 2867358 SGTC_2691 st077356 60.2 µM 2.90891664557119 0.00122933075819416 no 39 0.00181341772631874 83 2839272 SGTC_1910 st062352 60.4 µM 2.89656911932655 0.00128257745045552 no 40 0.00188633762327078 93 2245730 SGTC_848 0368-0089 85.6 µM 2.88835776216701 0.00131914645681144 no 41 0.0019362956545385 52 762535 SGTC_2196 6573537 42.6665 µM 2.86779577977285 0.00141493815250918 no 42 0.00206671121252921 43 2903087 SGTC_1977 st070720 65.3 µM 2.86468104135498 0.00142999038146421 no 43 0.00208714732434705 54 682188 SGTC_522 1273-0010 11.6 µM 2.8598704962578 0.00145352516130974 no 44 0.00211907019803077 74 5705015 SGTC_1451 4152-0210 104 µM 2.85690192723263 0.00146822422877647 no 45 0.00213898998460327 89 659563 SGTC_2478 5763493 32.33 µM 2.85495067955973 0.00147795971430647 no 46 0.00215217563775508 74 1365576 YLR208W SEC13 SGTC_716 1683-5115 658 µM 2.83838128945866 0.00156303490808091 no 47 0.00226714910849303 82 723597 SGTC_1804 st050076 49.1 µM 2.79419824192444 0.00181216473614513 no 48 0.00260142864499713 74 3895976 SGTC_654 1124-0271 80.9 µM 2.76925516834336 0.00196826037607519 no 49 0.00280923067447899 95 5403748 SGTC_413 propylparaben 100 µM 2.75688746098073 0.00205010153631556 no 50 0.00291772157628784 87 7175 A pharmaceutical preservative. SGTC_1779 st039427 55 µM 2.73634516026892 0.00219288440703804 no 51 0.00310629122558692 116 1124498 SGTC_3285 9112818 20.8695 µM 2.72505864669881 0.00227511461158448 no 52 0.00321450331546799 86 17017947 YPR165W RHO1 SGTC_2805 7950783 58.44 µM 2.72005082740951 0.0023124867208955 no 53 0.00326359412539558 95 1178958 YDL195W SEC31 SGTC_1424 4048-1941 275 µM 2.63906164343456 0.0029992131535493 no 54 0.0041567931205766 100 X1424 SGTC_2218 6965428 192.983 µM 2.61670355518532 0.00321871768465067 no 55 0.00443917050410956 63 675684 SGTC_1586 deoxycorticosterone acetate 53.7 µM 2.610305439512 0.00328413837845945 no 56 0.00452307064834234 77 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2686 alizarin 95.37 µM 2.55243558409214 0.00393240436122263 no 57 0.00534863441487292 117 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_998 3996-0085 177 µM 2.55043611639818 0.00395672205272305 no 58 0.00537941198576012 103 715391 SGTC_1196 1588-0294 184 µM 2.54697944680375 0.0039990802120756 no 59 0.00543299163858441 87 6144269 SGTC_2526 patulin 37.61 µM 2.54529659555668 0.00401984852461772 no 60 0.00545924771663495 225 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1547 harmine 94.2 µM 2.53323598049912 0.00417153801304086 no 61 0.00565074206823652 157 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2621 lithochol-11-enic acid 100 µM 2.5246325028371 0.00428285460220891 no 62 0.0057909667053842 137 6708711 SGTC_2415 st077333 57.7 µM 2.49798105462624 0.00464473296674951 no 63 0.00624514344305183 177 2766255 SGTC_798 1287-0182 476 µM 2.4920384919843 0.00472905012878149 no 64 0.00635061359691497 127 1649755 SGTC_1115 galangin 695.678 nM 2.47607627992268 0.0049623303281269 no 65 0.00664175971671875 114 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_715 0868-0130 184 µM 2.47229483626206 0.00501907446421799 no 66 0.00671243730794113 78 2876258 SGTC_421 streptovitacin 30 mM 2.47128493053993 0.0050343265035438 no 67 0.00673142519649062 128 91467 include heat shock SGTC_1200 1643-0193 18.4 µM 2.46777112161812 0.00508771572825287 no 68 0.00679786096839871 108 5403974 SGTC_1016 4226-1401 38 µM 2.44839474119173 0.00539127548316959 no 69 0.00717471751115064 130 2901613 SGTC_2860 9025725 38.96 µM 2.44426707069825 0.00545798469993483 no 70 0.00725733868885125 98 40546248 SGTC_1088 bifonazole 369 nM 2.44120523153623 0.00550794138380534 no 71 0.00731916657548623 100 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_3260 9137109 49.47 µM 2.43460457756836 0.00561702123522565 no 72 0.00745403562284477 68 17478346 SGTC_2123 5259487 200 µM 2.43163731149613 0.00566667909760024 no 73 0.00751537492609955 123 2173474 SGTC_3282 9108498 15.4605 µM 2.42716632950942 0.00574223817163867 no 74 0.00760863875010577 137 16459645 SGTC_1636 st007707 68.9 µM 2.42271771543989 0.0058183053745565 no 75 0.00770244593644408 166 403051 SGTC_2310 7668677 200 µM 2.41619854140342 0.00593139232336705 no 76 0.00784175350466699 150 2197143 SGTC_2382 9035899 200 µM 2.39502253699558 0.00631229321891672 no 77 0.00830967185842421 117 6462679 SGTC_372 0155-0182 15.9 µM 2.39161407391083 0.00637558513293674 no 78 0.00838723514935399 147 771486 SGTC_1382 3002-2117 298 µM 2.38602771992608 0.00648053353449753 no 79 0.00851573362766537 101 1497314 SGTC_2549 cedrol 20.94 µM 2.38056366772879 0.00658465978326528 no 80 0.00864308679355092 111 6708665 A sedative which affects the nervous system. SGTC_2285 7945142 200 µM 2.37707322235045 0.00665194760981961 no 81 0.00872531183179071 136 2970608 SGTC_1029 k015-0030 64.7 µM 2.36542939267137 0.0068808305599819 no 82 0.00900458848444423 154 2208316 SGTC_1401 3807-4679 7.6 µM 2.36009538784144 0.00698798427983424 no 83 0.00913511827140214 111 3291456 SGTC_645 0845-0943 5.41 µM 2.35790031860397 0.00703250665262487 no 84 0.00918931365957586 116 1885106 SGTC_2156 5649887 115 µM 2.35168536924133 0.00715992460061249 no 85 0.00934428759883682 141 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1722 st034304 3.6505 µM 2.3326377963745 0.00756320854798261 no 86 0.00983358172781897 175 4036148 YLR033W RSC58 SGTC_315 k915-0449 187 µM 2.32662805665907 0.00769453583932257 no 87 0.00999253496624076 203 20970215 YNL149C PGA2 SGTC_2407 paclitaxel 400 µM 2.31629922204116 0.00792493962651814 no 88 0.0102709683971343 176 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_763 3453-1109 128 µM 2.31457535881953 0.00796397878164884 no 89 0.0103180913495203 142 1560353 SGTC_2804 7954240 19.48 µM 2.29992253582202 0.00830269596662826 no 90 0.0107263045478578 163 828705 SGTC_518 1021-0119 62.6 µM 2.28859735863139 0.00857309414310905 no 91 0.0110513787581036 184 1097762 SGTC_24 0417-1663 219 µM 2.28076272451321 0.00876464484163725 no 92 0.0112812456172834 130 4329390 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 2.27049934059509 0.00902124737768358 no 93 0.0115886516294364 138 4213774 SGTC_2111 5486399 200 µM 2.26490577834751 0.0091638477502562 no 94 0.01175923105628 212 689674 SGTC_2266 7929956 200 µM 2.26320087027094 0.00920770268830746 no 95 0.0118116548052395 164 2967153 SGTC_2008 4012253 172 µM 2.26240582126052 0.00922821627121121 no 96 0.011836170802297 188 603940 SGTC_35 0133-0054 64.071 µM 2.25786458790574 0.00934615605511806 no 97 0.0119770514897098 151 99677 SGTC_638 3970-0837 4.09 µM 2.24428510748751 0.00970672910131092 no 98 0.0124070315653892 183 4118451 YLR208W SEC13 SGTC_2061 5245884 80.95 µM 2.24274525286743 0.00974837401377147 no 99 0.0124566233393217 163 573863 SGTC_1302 1159-0335 255 µM 2.24062884052548 0.00980586641175545 no 100 0.0125250634764708 128 649284 SGTC_1830 st055982 50.3 µM 2.23929075605339 0.00984236813216492 no 101 0.0125685019784118 160 455313 An antimicrobial agent. SGTC_22 0964-0034 14.468 µM 2.22872659002043 0.0101347390197374 no 102 0.0129160509701991 206 138402 SGTC_2693 st077581 40.7 µM 2.21722153170334 0.0104617422530468 no 103 0.0133039784596329 220 25238761 SGTC_604 1000-0114 314 µM 2.21298102478752 0.0105845669861903 no 104 0.0134494769417111 166 1572745 SGTC_839 0122-0028 230 µM 2.21134072315371 0.0106324135865955 no 105 0.0135061256657763 218 759448 SGTC_3238 9133470 49.47 µM 2.21006036179203 0.0106698917552422 no 106 0.0135504866752646 117 3534688 SGTC_2088 5278280 127.392 µM 2.20055132749558 0.0109518537817455 no 107 0.0138839012524852 201 791502 SGTC_1795 st049545 62.3 µM 2.19167226247048 0.0112209667075624 no 108 0.014201589979347 131 5291882 SGTC_1308 1187-1617 41.4 µM 2.1871686067939 0.0113596509206869 no 109 0.0143651088616162 207 2882570 SGTC_1079 idarubicin 2.36 µM 2.18617808564737 0.0113903517721537 no 110 0.0144012894475609 136 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2272 7805186 180 µM 2.18392592978855 0.0114604249697901 no 111 0.014483845651579 122 2956062 YPR165W RHO1 SGTC_653 0203-0016 55.2 µM 2.17289393593382 0.0118091082574562 no 112 0.0148941504952806 181 295302 SGTC_1032 k061-1018 98.7 µM 2.17228438280968 0.0118286396589144 no 113 0.0149171096281104 206 4005393 SGTC_2857 9024691 58.44 µM 2.16971547885834 0.011911261184037 no 114 0.0150142033528885 184 16478292 SGTC_252 miconazole 1.30953 nM 2.16771212838937 0.0119760402504933 no 115 0.0150902980513832 194 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1082 camptothecin 424.86 nM 2.16718972205777 0.0119929825905846 no 116 0.0151101953793625 203 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1061 3448-9325 110 µM 2.14566719940844 0.0127092916331738 no 117 0.0159497699442265 137 723482 SGTC_1935 st074532 41.6 µM 2.14148771438828 0.01285260522505 no 118 0.0161173640876157 224 2829742 SGTC_1132 3456-3614 2.5 µM 2.14071343506961 0.0128793079893387 no 119 0.016148577204084 262 3125502 SGTC_3071 9117417 49.47 µM 2.13990166933513 0.0129073550648685 no 120 0.0161813570918781 128 45595590 YGL055W OLE1 SGTC_1257 0669-0121 16 µM 2.12555144618831 0.0134119557990448 no 121 0.0167703130460541 208 4307855 SGTC_373 0844-0104 25.9 µM 2.12246029617756 0.0135228534712006 no 122 0.0168995517182301 229 5375804 SGTC_2099 5377090 177.372 µM 2.11377260027707 0.0138387801308918 no 123 0.0172673471258909 207 2243829 SGTC_899 1083-0020 478 µM 2.11323788402472 0.0138584312548147 no 124 0.0172902061402392 197 767123 SGTC_1982 st072467 71.9 µM 2.1106533776291 0.0139537529190741 no 125 0.0174010580401423 246 3163533 SGTC_418 lividomycin a 100 µM 2.10492758843443 0.0141669464315411 no 126 0.0176488058861749 163 72394 An antibiotic. SGTC_371 0195-0006 7.36 µM 2.10248013196203 0.0142589274868263 no 127 0.0177556191322537 160 3928593 SGTC_1162 k048-0130 20.1 µM 2.09831774203426 0.0144165411941206 no 128 0.0179385431334462 179 6797406 SGTC_2771 fluoxetine 41.05 µM 2.09470047399935 0.0145547291493776 no 129 0.0180988135402637 184 3386 A selective serotonin reuptake inhibitor. SGTC_3150 9097574 49.47 µM 2.08730900901779 0.0148406480037546 no 130 0.0184301054739827 151 17217476 SGTC_2380 9035439 200 µM 2.08436752774005 0.0149557675557206 no 131 0.0185633746020904 217 6462575 SGTC_854 0422-0053 192 µM 2.08125419823178 0.0150784480793141 no 132 0.0187053225297049 173 3596728 SGTC_617 3770-0098 35 µM 2.07823845344511 0.0151981068526344 no 133 0.0188437009962795 175 5962639 SGTC_3014 9081533 49.47 µM 2.07675625027065 0.0152572161263072 no 134 0.0189120310051142 164 21367265 SGTC_1664 st014217 9.02 µM 2.07633150278693 0.0152741911300976 no 135 0.0189316508018199 188 3982782 SGTC_965 1291-5240 308 µM 2.07536911038901 0.0153127131005087 no 136 0.0189761693810294 209 2834598 SGTC_2886 9058944 51.95 µM 2.07339326259382 0.0153920625083037 no 137 0.0190678477258815 76 4949929 SGTC_1445 4239-0156 97.7 µM 2.06933665811683 0.0155560814689231 no 138 0.0192572529741771 230 4008346 SGTC_2706 st078239 82.5 µM 2.03912536517823 0.0168254419633226 no 139 0.0207187586327918 194 15434492 SGTC_1771 st048882 4.1505 µM 2.03649217862687 0.0169401610663495 no 140 0.0208504788478804 209 4580403 SGTC_1806 st050005 60.3 µM 2.02103167876689 0.0176272997249914 no 141 0.0216382429411634 214 5194765 SGTC_485 niflumic acid 177 µM 2.01853286567445 0.0177405626104606 no 142 0.0217678974371814 181 4488 A COX2 inhibitor. SGTC_1971 st069429 63.5 µM 2.01661212818444 0.0178280447972932 no 143 0.0218680031793768 171 1246522 YGL099W LSG1 SGTC_2555 cholic acid 100 µM 2.01569704073256 0.0178698527569509 no 144 0.0219158326292565 188 6708657 Influences liver metabolism. SGTC_628 1636-0253 16 µM 2.00732159118332 0.0182564054550076 no 145 0.0223577158050091 252 4456143 SGTC_1476 4112-3294 3.34 µM 2.00153336843397 0.0185276938453118 no 146 0.0226674707516797 190 704369 SGTC_2398 5228213 48.84 µM 1.989660938897 0.0190948969681493 no 147 0.0233141491650059 298 80771 YMR134W ERG29 SGTC_1397 3532-0190 20.1 µM 1.98820423964264 0.0191654969453147 no 148 0.0233945531449213 153 5322280 SGTC_53 0973-0023 39.979 µM 1.98166778710138 0.019485028794716 no 149 0.0237582174067445 201 674768 SGTC_1773 st048542 73.5835 µM 1.98127359590463 0.0195044425026321 no 150 0.0237802998859428 262 3237138 SGTC_2104 5389443 200 µM 1.97822909530574 0.01965493672623 no 151 0.0239514339173432 247 2244536 SGTC_1021 4476-0760 85.3 µM 1.97666984320997 0.0197323939194824 no 152 0.0240394808606907 238 746768 SGTC_1368 1852-0141 284 µM 1.97317233425237 0.0199070786230518 no 153 0.0242379656679334 237 2838987 SGTC_1134 3477-0009 42.5 µM 1.97194736957689 0.019968569526024 no 154 0.0243078074724508 268 3973534 SGTC_664 1222-0054 14.9 µM 1.96828250892065 0.0201535016608979 no 155 0.0245177706637529 243 6813991 SGTC_3127 9126946 49.47 µM 1.96561366038443 0.0202890863044874 no 156 0.0246716274688631 199 27243249 SGTC_420 mitomycin C 81.9 mM 1.96001388499387 0.0205760846501565 no 157 0.0249970837071085 239 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2401 5128683 200 µM 1.95683109624014 0.0207407357640617 no 158 0.0251836648814892 230 708373 SGTC_2523 spermine 47.74 µM 1.95666754386808 0.0207492266616934 no 159 0.0251932840783679 217 1103 A DNA binding polyamine. SGTC_3080 9117754 49.47 µM 1.95605028565103 0.020781298431428 no 160 0.0252296153500951 246 9550191 SGTC_558 k064-0027 21.3 µM 1.95252746091624 0.0209651433185731 no 161 0.0254378069590884 238 5088526 SGTC_2338 7999974 200 µM 1.94271809214558 0.0214843300214864 no 162 0.026025114516697 250 315925 SGTC_2175 5807670 165.306 µM 1.94134556487854 0.0215578341884996 no 163 0.0261081881126167 221 241186 SGTC_27 0485-0001 32.618 µM 1.93784584996922 0.0217462199548398 no 164 0.0263210160241108 141 2054479 SGTC_1272 0839-0021 27 µM 1.93589571118077 0.0218517958033104 no 165 0.0264402375727016 243 5027250 SGTC_824 1304-0008 100 µM 1.93583952133053 0.0218548441920799 no 166 0.0264436794116041 286 768245 SGTC_1043 0916-0009 19.3 µM 1.93176127820505 0.0220770563642547 no 167 0.0266944887243979 294 3101130 SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.92573710280165 0.0224087841801291 no 168 0.0270686042891662 113 6708630 An antioxidant. SGTC_1478 0453-0656 35.7 µM 1.92311063970587 0.0225547238390945 no 169 0.0272330782089489 232 5258496 SGTC_2413 inermin 26.06 µM 1.92017475798223 0.0227188040734784 no 170 0.0274179144421159 290 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2620 irigenin 100 µM 1.90774618629319 0.023424596802804 no 171 0.0282120145493234 281 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2389 9091542 195.52 µM 1.90609841023158 0.0235195412998165 no 172 0.028318719468011 278 3626624 YOL127W RPL25 SGTC_395 anisomycin 6.25 µM 1.9030888471204 0.0236937873112681 no 173 0.0285144764915968 194 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_497 capsazepine 133 µM 1.88533747694704 0.02474377130205 no 174 0.0296921447133374 230 2733484 A calcium channel blocker. SGTC_290 2043-6722 48.1 µM 1.88304302039201 0.0248822936204336 no 175 0.0298472690362703 235 773758 YLR208W SEC13 SGTC_2430 5571206 200 µM 1.87760129931202 0.0252134264433408 no 176 0.0302178639345852 302 1731771 SGTC_859 0439-0102 54.6 µM 1.87674693787126 0.02526574888349 no 177 0.0302763930625815 262 610143 SGTC_224 benfluorex 43.875 µM 1.86533123038513 0.0259736369527525 no 178 0.0310674950974852 148 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_332 4112-0506 40.9 µM 1.86336958167043 0.0260969338993958 no 179 0.0312051433071569 240 2790355 SGTC_3040 9091894 49.47 µM 1.86153595893189 0.0262126261747629 no 180 0.0313342637429115 199 25236966 SGTC_1540 guanosine 70.6 µM 1.85738290588922 0.0264762489291211 no 181 0.0316283483656182 217 6802 Guanosine is a purine nucleoside SGTC_1177 0983-0204 23.6 µM 1.85545402886027 0.026599439340301 no 182 0.0317657090700991 253 766818 SGTC_561 1550-0330 72.9 µM 1.84776358553978 0.0270953703584978 no 183 0.0323182754515107 246 6812934 SGTC_576 1073-0113 22.7 µM 1.84533033283261 0.0272538805071239 no 184 0.0324947503113241 412 5439563 SGTC_2602 kawain 100 µM 1.84462392766006 0.0273000427006045 no 185 0.0325461319139533 308 5369129 SGTC_1626 st003712 1.76 µM 1.84229451447648 0.027452727629263 no 186 0.0327160408666937 255 24207035 SGTC_1340 1486-1359 257 µM 1.84208413553984 0.0274665522250866 no 187 0.0327314219912796 268 4309068 SGTC_291 SEC14.278 35.5 µM 1.84049092997052 0.0275714348160037 no 188 0.0328480973279589 249 1068044 SGTC_2899 9053889 58.44 µM 1.84046354955009 0.0275732402152106 no 189 0.0328501054729517 205 6470052 SGTC_875 0709-0210 25.7 µM 1.8335282958746 0.0280337184918436 no 190 0.0333620222805219 313 6251364 SGTC_2002 4023503 131 µM 1.83126226549446 0.0281855566308134 no 191 0.0335307034880145 366 4736863 YCR052W RSC6 SGTC_891 0929-0073 133 µM 1.82325188338331 0.0287277999340703 no 192 0.0341326251186039 244 5603632 SGTC_2362 9071156 126 µM 1.82177959287187 0.0288284007451578 no 193 0.0342442176926294 275 653133 SGTC_1685 st024049 53.0905 µM 1.81847366292189 0.029055360570756 no 194 0.0344958842782755 240 1941139 SGTC_1379 2144-0755 36.5 µM 1.81579677120327 0.0292402215039636 no 195 0.034700776388597 302 5392327 SGTC_1850 st056238 17 µM 1.80791006135033 0.0297905491718052 no 196 0.0353102497892705 297 5393177 SGTC_826 1683-5028 118 µM 1.80773719318022 0.0298027073444558 no 197 0.0353237064959214 255 722377 SGTC_381 3461-2219 42.7 µM 1.80699363479534 0.0298550502716953 no 198 0.035381635832856 292 2883159 SGTC_3354 9151612 71.43 µM 1.80676250283865 0.0298713363755386 no 199 0.0353996587853209 284 27261949 SGTC_2999 9069765 71.4286 µM 1.80505487439717 0.0299918883907845 no 200 0.0355330477566401 283 2097066 SGTC_722 3534-0461 190 µM 1.80395201586802 0.030069960186069 no 201 0.03561941478531 303 658262 SGTC_1808 st050063 61.5 µM 1.80011634451962 0.0303428021072626 no 202 0.0359211346564441 262 4011993 SGTC_2190 6049624 200 µM 1.78779164247726 0.0312334114863125 no 203 0.0369048148763205 213 2265554 SGTC_3024 9090631 49.47 µM 1.77162498725483 0.0324343224956654 no 204 0.0382284145192892 229 25236383 SGTC_2291 7917025 104.35 µM 1.76934772695347 0.0326065062588072 no 205 0.0384179316338803 344 2964612 SGTC_2456 5770359 74.46 µM 1.76637135454952 0.0328326857717413 no 206 0.0386667838217616 275 3118787 SGTC_1492 4158-0558 28.5 µM 1.75281675390696 0.033879137138072 no 207 0.0398167331926103 280 3967268 SGTC_2173 5763948 167 µM 1.74819190376389 0.0342424055403726 no 208 0.0402154015360521 306 2867177 SGTC_501 nsc-95397 161 µM 1.74379135948757 0.0345910219840189 no 209 0.0405977388509315 257 262093 SGTC_601 0986-0029 62.9 µM 1.74248463943399 0.0346951015230989 no 210 0.0407118384872944 356 24747981 SGTC_1777 st045864 34.765 µM 1.74046514332765 0.03485645902813 no 211 0.0408886877453893 298 4691462 SGTC_1798 st045719 60.953 µM 1.74012800416776 0.03488345632278 no 212 0.0409182719673274 241 3980186 SGTC_251 melphalan 456.522 µM 1.73528390639858 0.0352732586995389 no 213 0.0413452654439733 356 460612 A DNA alkylator. SGTC_523 1934-0222 13.7 µM 1.73426034422017 0.0353560798582567 no 214 0.041435950134021 333 1361595 SGTC_525 k781-2675 26.7 µM 1.73260354111451 0.0354904774314717 no 215 0.0415830797192659 354 3651118 YDL195W SEC31 SGTC_1761 st044296 37 µM 1.73120006746063 0.0356046527100544 no 216 0.0417080436729198 306 1826700 SGTC_102 gallobenzophenone 83.616 µM 1.72589564016568 0.0360389005446867 no 217 0.042183094615287 342 70837 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 1.72537815181352 0.0360814960551052 no 218 0.0422296730266096 332 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_888 0916-0002 6.97 µM 1.72491540965627 0.0361196202048172 no 219 0.0422713590449108 297 2802138 YIL048W NEO1 SGTC_220 paclitaxel 373.376 µM 1.72168200944396 0.0363869332643582 no 220 0.0425635690278627 244 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1423 4048-0112 5.59 µM 1.72115968708949 0.0364302664460362 no 221 0.0426109254080242 312 X1423 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.71664215555728 0.0368068171005054 no 222 0.0430222875467538 288 279621 SGTC_1849 st056239 19.2 µM 1.71626127116158 0.0368387099858039 no 223 0.0430571166780268 345 5393181 SGTC_2914 7968218 45.32 µM 1.7160057478745 0.0368601185754449 no 224 0.0430804952040453 243 2977111 SGTC_205 1486-1330 71.903 µM 1.71472861785209 0.0369672733079697 no 225 0.0431974970816151 243 4118834 SGTC_711 k292-0785 179 µM 1.7113947780889 0.0372481920843153 no 226 0.0435041302595134 316 4146315 SGTC_683 panaxydol 45 µM 1.7059069349778 0.037714410018349 no 227 0.0440127041837896 334 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2309 7664088 163.95 µM 1.69107252357549 0.0389985424376806 no 228 0.0454114760952909 385 704922 SGTC_1715 st032160 10.2275 µM 1.68901399602643 0.0391795181385906 no 229 0.0456083739142602 308 5289825 SGTC_292 k038-0015 474 µM 1.68777392595581 0.0392888685771133 no 230 0.0457273173044449 316 46368540 SGTC_1829 berberine 14.4 µM 1.6842831331321 0.0395980237961946 no 231 0.0460634817497168 303 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.68355965582925 0.0396623440065821 no 232 0.0461334005833459 334 165521 SGTC_2217 6934799 96.0675 µM 1.67617605931431 0.0403236468982646 no 233 0.0468518560535527 298 675606 SGTC_2839 9003951 25.97 µM 1.67249788486507 0.0406564041431059 no 234 0.0472130923011746 306 2990634 SGTC_1059 3448-6867 171 µM 1.66173353064751 0.041643055830837 no 235 0.0482831074492125 337 3934407 SGTC_1787 fluconazole 80 µM 1.66028728021995 0.0417770837242114 no 236 0.0484283366821291 432 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2777 climbazole 1.536 µM 1.66015563650245 0.0417893008261565 no 237 0.0484415733783102 380 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2870 9038528 12.99 µM 1.65814763798152 0.0419760105992293 no 238 0.0486438352854963 308 6463316 SGTC_2397 5161689 200 µM 1.6567394746946 0.0421073482862487 no 239 0.0487860792354108 373 2259942 SGTC_2235 salicylic acid 500 µM 1.65571493132671 0.0422031150706871 no 240 0.0488897810451327 262 338 A COX inhibitor and kinase inhibitor. SGTC_2411 st077133 39.94 µM 1.64984800345004 0.042754911722752 no 241 0.0494870138986294 407 1403142 YNL221C POP1 SGTC_1746 st038117 42 µM 1.64465603161882 0.0432480779365106 no 242 0.0500203824331586 369 2898218 SGTC_2581 avocatin a 64 µM 1.6435150839892 0.0433570656767394 no 243 0.0501382035303657 390 6710728 A skin care supplement. SGTC_2898 9056270 58.44 µM 1.63456447241419 0.0442197761018032 no 244 0.0510701902267423 277 19154699 SGTC_627 1391-0720 175 µM 1.63053361024044 0.0446127863374162 no 245 0.0514943838369773 342 997839 SGTC_1516 st013856 110 µM 1.62829974356603 0.0448317977168576 no 246 0.051730671920873 318 5281404 A mutagen and neurotoxin. SGTC_1620 st003704 16.5 µM 1.62447678992037 0.0452086130742224 no 247 0.0521370450114799 323 2834414 SGTC_3262 9137218 49.47 µM 1.61327816310355 0.0463271055406738 no 248 0.0533420442789016 190 17650664 SGTC_782 0083-0095 30.5 µM 1.61260480828215 0.0463950605295025 no 249 0.0534151965952804 413 3591729 An indicator and reagent. SGTC_2906 7926292 26.41 µM 1.61171600802375 0.0464848807750926 no 250 0.0535118762957502 381 2966319 SGTC_3111 9122088 49.47 µM 1.61149889977557 0.0465068424658518 no 251 0.0535355134131076 237 16876704 SGTC_2442 5158906 48.48 µM 1.60783515119516 0.0468787082703407 no 252 0.0539356438134094 378 1893835 SGTC_3119 9125183 49.47 µM 1.60325052127873 0.0473473975246031 no 253 0.0544396777570817 236 22695334 SGTC_2253 7938677 135.83 µM 1.59974373093914 0.0477084272391173 no 254 0.0548277231058537 342 2301972 SGTC_424 splitomicin 100 mM 1.59511505649029 0.0481883283037391 no 255 0.0553432545649907 360 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2261 9010538 184.68 µM 1.57832684175843 0.0499614196083447 no 256 0.0572452712573739 309 6457250 SGTC_1924 st058459 75.1 µM 1.57805966461324 0.04999005259967 no 257 0.0572759517306493 333 688683 SGTC_2751 anetholtrithion 17.25 µM 1.56964052726878 0.0508990413187788 no 258 0.0582493822162243 402 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_567 1080-0542 68.4 µM 1.56880843479669 0.0509895897777813 no 259 0.0583462912121733 346 5950415 SGTC_1311 1190-0148 100 µM 1.56638600351493 0.0512539293401624 no 260 0.0586291388241625 480 1961333 SGTC_916 4466-0038 42 nM 1.5642940592407 0.0514830818965526 no 261 0.0588742633160391 519 5722064 YGL116W CDC20 SGTC_2046 4110841 106 µM 1.56223635350637 0.051709278072799 no 262 0.0591161597289572 372 44119630 YMR134W ERG29 SGTC_3205 9113483 49.47 µM 1.56159691785567 0.0517797295968904 no 263 0.0591914880139107 421 17018033 SGTC_659 k018-0002 107 µM 1.558707635134 0.0520990156774224 no 264 0.0595327969232811 400 6797879 YHR007C ERG11 SGTC_12 0849-0099 9.267 µM 1.55727465775968 0.0522579489061577 no 265 0.0597026447707485 375 6071388 SGTC_528 3492-0019 172 µM 1.55701764917512 0.0522864947126929 no 266 0.059733147583063 634 2869262 SGTC_1837 st055472 66.5 µM 1.55347650898675 0.0526810692014075 no 267 0.0601546685462696 388 676091 SGTC_2250 alverine citrate 130 µM 1.55097038237642 0.0529617415123522 no 268 0.0604543909364043 570 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_801 0866-0028 10.1 µM 1.54914883737916 0.0531664877524786 no 269 0.0606729725764025 426 6849771 SGTC_2289 7946404 165.07 µM 1.54744033225677 0.053359097878083 no 270 0.0608785510125993 512 1246120 YPR165W RHO1 SGTC_2934 9036370 36.88 µM 1.53870380882819 0.054352677604406 no 271 0.0619383110312672 440 6462800 SGTC_3217 9129673 49.47 µM 1.53862838100723 0.0543613190880904 no 272 0.0619475228838255 409 17248312 SGTC_1932 st074806 40.9 µM 1.52612538750727 0.0558088252320783 no 273 0.0634893202951225 437 17251235 SGTC_700 3453-2283 142 µM 1.5246142219162 0.055985818037838 no 274 0.063677674002827 474 565664 SGTC_3324 9138759 60.749 µM 1.5218873336733 0.0563063203903219 no 275 0.064018656725768 396 45595710 SGTC_3180 9109287 49.47 µM 1.51622406491768 0.056976567694664 no 276 0.0647313524880591 350 18891271 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 1.51400562576171 0.0572408258485892 no 277 0.0650122063247476 489 688788 SGTC_1739 st037196 92.5 µM 1.51246910602755 0.0574244191791569 no 278 0.0652072830913514 424 612214 SGTC_2752 diclazuril 33.15 µM 1.51046785242061 0.0576642361930342 no 279 0.0654620431780863 593 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2245 6637752 200 µM 1.5086510412245 0.0578826322551543 no 280 0.0656939915783417 339 681890 SGTC_3346 9158254 43.5805 µM 1.50618018484489 0.0581806929003781 no 281 0.0660104623716681 431 17639500 SGTC_872 0588-0139 234 µM 1.49923125528446 0.0590254124218697 no 282 0.0669068246539605 452 2047100 SGTC_1938 st074717 56.4 µM 1.49859779813459 0.0591028922164721 no 283 0.0669890021476866 354 17250979 SGTC_2176 5809774 33.9695 µM 1.4979797930116 0.0591785588892915 no 284 0.0670692502870462 421 2870539 SGTC_2082 5219693 150 µM 1.49649211638551 0.0593610170680393 no 285 0.0672627303938323 433 2834649 SGTC_3164 9100705 49.47 µM 1.49634662759067 0.0593788843939178 no 286 0.0672816751101756 338 17174235 SGTC_139 0099-0334 718.624 µM 1.48971478190481 0.0601978197089271 no 287 0.0681496231101722 514 97690 SGTC_1125 tnp00248 1.32998 µM 1.48932533040151 0.0602461847361162 no 288 0.0682008603097798 536 24207736 SGTC_1851 st056236 18.9 µM 1.48926367770256 0.0602538440215712 no 289 0.0682089742160602 424 5393171 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.48554855087584 0.0607167928958059 no 290 0.0686992861484453 523 368090 SGTC_2292 7671323 168.05 µM 1.48277978898645 0.0610636191432165 no 291 0.0690664637787489 449 937504 SGTC_31 0508-1974 57.237 µM 1.48133420596015 0.061245312966027 no 292 0.0692587688640134 432 6810525 SGTC_1863 st057641 20.1 µM 1.48102030130067 0.0612848230838828 no 293 0.0693005818830372 461 3921635 SGTC_3326 9140064 16.379 µM 1.47466011574696 0.0620896550914348 no 294 0.0701519720060876 408 1868434 SGTC_2612 dictamnine 15.46 µM 1.47188432452262 0.0624434844712788 no 295 0.0705260586492166 443 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_89 0302-0250 142.109 µM 1.47056961772955 0.0626116175309436 no 296 0.0707037727527439 475 4203518 YLR208W SEC13 SGTC_265 mycophenolic acid 32.932 µM 1.46202325810877 0.0637131969879595 no 297 0.0718674182667591 474 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.45202761750215 0.0650206446283784 no 298 0.0732469631319338 457 94937 An inhibitor of serotonin biosynthesis. SGTC_190 3970-0790 3.722 µM 1.44730340308173 0.0656457829482364 no 299 0.0739059832163471 402 2832352 SGTC_1224 0823-0416 294 µM 1.44457764545242 0.0660085868192876 no 300 0.0742882778112205 448 3598164 SGTC_2225 6654152 15.4 µM 1.44386429060787 0.066103791823779 no 301 0.074388576574269 355 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2502 avocadyne acetate 18.59 µM 1.44361249934069 0.0661374215101399 no 302 0.0744240034818501 518 3952079 SGTC_775 4577-0580 57.3 µM 1.44221088399627 0.0663248660069512 no 303 0.0746214455367326 450 2006902 SGTC_2351 9026858 72.31 µM 1.43949688185246 0.0666889912803535 no 304 0.0750048963945767 421 1409300 SGTC_790 1575-0012 79.1 µM 1.43816402807674 0.0668683796933558 no 305 0.0751937595345212 466 378741 YLR208W SEC13 SGTC_2921 7974240 10.71 µM 1.43787591142069 0.0669072062587152 no 306 0.0752346328005752 455 2979074 YDR527W RBA50 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.43257300836875 0.0676249433863022 no 307 0.075989949989445 516 676296 Flavone; oxidizing agent. SGTC_1363 1636-0063 10.4 µM 1.43101150771876 0.0678374190770148 no 308 0.0762134585311755 486 6072185 SGTC_967 1306-0166 352 µM 1.42715812849372 0.068363960025542 no 309 0.0767671602710395 474 4437607 SGTC_737 1950-0117 57.9 µM 1.41673988604683 0.0698033397606266 no 310 0.0782794954763181 462 5393513 SGTC_600 1495-0418 41.6 µM 1.41633568167098 0.0698596509307444 no 311 0.0783386227592467 456 5377768 SGTC_1591 genipin 88.4 µM 1.41598721802545 0.069908224713692 no 312 0.0783896234284174 412 442424 A DNA cross-linking agent. SGTC_233 rapamycin 362 pM 1.41493943672208 0.0700544358324345 no 313 0.0785431269425664 461 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1828 st055811 49 µM 1.41377404796349 0.0702173345361322 no 314 0.0787141278793568 405 5877589 SGTC_3347 9188721 44.724 µM 1.41233977744723 0.070418217408585 no 315 0.0789249697197612 425 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1203 3992-3522 103 µM 1.4087389230904 0.0709244974321676 no 316 0.0794561905387369 518 5322312 SGTC_2437 5741531 144.16 µM 1.40869866792647 0.0709301730691696 no 317 0.0794621444921411 500 2262990 SGTC_862 0452-0056 10.2 µM 1.40843117651589 0.0709678959532624 no 318 0.0795017164746519 451 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_472 calcifediol 10 µM 1.40729652918421 0.0711280805370471 no 319 0.0796697390531244 388 5283731 A vitamin D metabolite. SGTC_2459 5811157 9.22 µM 1.40516424181643 0.0714298585354953 no 320 0.0799862222872747 457 2870684 YBR192W RIM2 SGTC_1877 wortmannin 25 µM 1.39582414187482 0.072763333008462 no 321 0.0813837292707751 544 312145 A covalent inhibitor of PI 3-kinase. SGTC_1220 1838-0075 193 µM 1.3885606455074 0.0738134440032804 no 322 0.0824831957078138 499 5529645 SGTC_1923 st058458 19.1 µM 1.38855652767699 0.0738140426012772 no 323 0.0824838221745617 540 3534982 SGTC_2761 levamisole 97.89 µM 1.38801959092569 0.0738921274479651 no 324 0.0825655398166631 473 26879 An alkaline phosphatase inhibitor. SGTC_2280 7785178 200 µM 1.38535292836838 0.074280866442017 no 325 0.082972288431187 448 2954328 SGTC_3075 9116269 49.47 µM 1.3776742019952 0.0754089747889116 no 326 0.0841519499279342 495 17015205 YNL244C SUI1 SGTC_2955 9076254 12.21 µM 1.37249144795724 0.0761777409299251 no 327 0.0849552496824586 444 16459619 SGTC_2128 5255449 168.493 µM 1.37064755828669 0.0764526819791638 no 328 0.0852424249482078 525 736008 SGTC_1359 1582-0056 520 nM 1.36772045443093 0.0768906898347188 no 329 0.0856997974336206 550 3661189 SGTC_3293 9120939 62.045 µM 1.36698909728288 0.0770004264190925 no 330 0.0858143614612198 479 934087 SGTC_3233 9132340 49.47 µM 1.3627529387991 0.0776383841565586 no 331 0.086480193725642 483 17682950 SGTC_1409 3909-8004 61.9 µM 1.3592908337596 0.0781627443105727 no 332 0.0870272237450489 518 2119279 SGTC_1567 st069303 68.4 µM 1.35669657669823 0.0785574201459424 no 333 0.0874388203313533 542 5581319 SGTC_278 4092-0821 23.9 µM 1.35223238046642 0.0792401116824137 no 334 0.0881504940953473 499 877900 SGTC_2444 5485484 36.41 µM 1.35167316782313 0.0793259454228038 no 335 0.0882399461809987 539 6790631 SGTC_1231 0242-0792 125 µM 1.35056215924311 0.0794966832996328 no 336 0.0884178646758447 508 3707635 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 1.35028683606356 0.0795390374561986 no 337 0.0884619966215878 561 23665772 A membrane-active detergent. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.34878036737524 0.0797710864280282 no 338 0.0887037612510481 495 688662 SGTC_921 1561-0023 372 µM 1.34874194433143 0.0797770116129823 no 339 0.0887099339768165 529 24050882 SGTC_2905 7799065 20.05 µM 1.34839584716892 0.0798303979672917 no 340 0.0887655494796162 478 1296806 SGTC_48 0382-0018 55 µM 1.34602394346162 0.0801969974141053 no 341 0.089147397459331 487 762596 SGTC_3271 9137798 49.47 µM 1.34550570411177 0.0802772651708566 no 342 0.0892309902429731 437 6498326 SGTC_1094 duloxetine 25.4 µM 1.34544981057926 0.0802859258940807 no 343 0.0892400094367198 524 60834 A selective serotonin reuptake inhibitor. SGTC_3152 9099253 49.47 µM 1.34315673462009 0.0806418478804049 no 344 0.0896106139188865 629 25236131 SGTC_3264 9137442 49.47 µM 1.34311306768566 0.0806486372295235 no 345 0.089617682409406 474 17015726 SGTC_316 k060-0003 58.6 µM 1.34233323910054 0.0807699579373731 no 346 0.0897439852963184 497 6152314 SGTC_681 1642-0006 26.6 µM 1.33472967992554 0.0819601020084089 no 347 0.0909824179485383 455 4446530 SGTC_85 0868-0259 160.055 µM 1.33324215834695 0.0821944734205259 no 348 0.0912261742511395 499 83173 SGTC_272 doxorubicin 8.13 µM 1.33320754670255 0.0821999327766579 no 349 0.0912318517306273 583 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3181 9108277 49.47 µM 1.3324512844248 0.0823192875596031 no 350 0.0913559697154891 500 17097298 SGTC_3287 9117173 37.0625 µM 1.33209695504019 0.0823752533890026 no 351 0.0914141654028301 436 2789709 SGTC_1665 st014639 11.4 µM 1.33113121817777 0.082527935626408 no 352 0.0915729192476745 566 981133 YIL048W NEO1 SGTC_1036 k216-0215 33.5 µM 1.32570921783808 0.0833891074228369 no 353 0.0924680164858619 578 622330 SGTC_1500 4488-1866 171 µM 1.32300517767123 0.0838211040855836 no 354 0.0929168279933814 577 2900003 SGTC_1572 epiandrosterone 68.9 µM 1.32221482473862 0.0839476875455679 no 355 0.0930483129536488 566 441302 A steroid. SGTC_1433 4060-0023 7.6 µM 1.32188376491496 0.0840007529479704 no 356 0.0931034296889717 550 3840627 SGTC_116 0155-0182 31.788 µM 1.32104745812369 0.0841349162885983 no 357 0.0932427702935269 662 771486 SGTC_1832 st054113 55 µM 1.32029545135126 0.0842556932127226 no 358 0.0933681968360225 486 1251267 SGTC_450 aminopyrene 156 nM 1.31579258124355 0.0849816055307772 no 359 0.0941218349888076 537 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_154 3389-1638 511.116 µM 1.31027440062509 0.0858775775246419 no 360 0.0950515121599946 474 5238686 SGTC_1263 0774-1208 64.8 µM 1.30844097604494 0.0861768249851443 no 361 0.0953618910078409 630 906585 SGTC_1703 st026983 48.3 µM 1.30793268040098 0.0862599258020186 no 362 0.0954480718875789 564 1104023 SGTC_1324 1418-0026 34.4 µM 1.30703546089296 0.0864067576896268 no 363 0.0956003341947693 560 1372513 SGTC_2740 felodipine 17.08 µM 1.30547894022678 0.0866619288254518 no 364 0.0958649068409197 449 3333 L-type calcium channel blocker SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.30347323685422 0.0869915674828179 no 365 0.096206623782817 534 6710655 SGTC_1807 st050092 58.9 µM 1.30287291349363 0.087090412905034 no 366 0.0963090763456395 524 5008496 SGTC_2121 5257820 149.641 µM 1.30098481016448 0.0874018427520467 no 367 0.096631827066762 583 791256 SGTC_489 paxilline 115 µM 1.30044737739629 0.0874906404448673 no 368 0.0967238404435684 505 105008 A toxic potassium channel blocker. SGTC_822 1487-0950 154 µM 1.29977622615955 0.0876016263828407 no 369 0.0968388379716095 537 1958375 SGTC_1030 k029-0042 36.7 µM 1.29967039791231 0.0876191364151508 no 370 0.0968569801331087 601 6080581 SGTC_742 0kpi-0133 140 µM 1.29797482780189 0.0879000366982161 no 371 0.0971479925019396 569 2728852 SGTC_3207 9114163 49.47 µM 1.28998593372013 0.0892325757424451 no 372 0.0985277710096957 628 849233 SGTC_2746 daunorubicin 9.88 µM 1.28821558519313 0.0895298919929962 no 373 0.0988354641175907 382 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1987 st072290 61.9 µM 1.28703192669595 0.0897290887717123 no 374 0.0990415801716069 573 54697379 SGTC_203 k066-0004 30.888 µM 1.28637838973832 0.0898392129780597 no 375 0.0991555182901501 651 6795412 SGTC_335 4077-0256 27.6 µM 1.28161822611109 0.0906443562917649 no 376 0.0999883016814786 631 3121989 SGTC_2130 NSC 7 2.4545 µM 1.27925186690204 0.0910465943319696 no 377 0.100404188235378 602 21448 SGTC_1447 4239-0816 81.9 µM 1.27740577106884 0.0913613152243513 no 378 0.1007295141844 545 1341554 SGTC_762 1165-0429 115 µM 1.27493640662988 0.0917835503185552 no 379 0.101165875840879 569 5967793 SGTC_1441 4106-0040 13 µM 1.2727696758857 0.0921552274279364 no 380 0.101549892350035 546 2904180 SGTC_2140 5586273 200 µM 1.26915480377622 0.0927777943335567 no 381 0.102192928568858 525 854421 SGTC_1738 st035555 74 µM 1.26863982968528 0.0928667376126558 no 382 0.102284775910042 574 5331140 SGTC_1270 0831-1170 17.3 µM 1.2657859718645 0.0933607820655002 no 383 0.10279485938245 622 6764716 SGTC_650 1328-0195 38 µM 1.26199292186617 0.0940204160060936 no 384 0.103475666669811 594 2780821 SGTC_2299 7976368 114.88 µM 1.2597668954921 0.094409133140629 no 385 0.103876732627369 552 2979718 SGTC_2242 6630449 61.2675 µM 1.25506811198232 0.0952335409636142 no 386 0.104727017585795 491 691249 YDR170C SEC7 SGTC_1691 st019933 84.6 µM 1.25199739489936 0.0957751589480208 no 387 0.105285406612597 552 6176082 SGTC_56 0957-0365 83.25 µM 1.25198560147765 0.0957772434496749 no 388 0.105287555310442 595 6752360 SGTC_3252 9135871 49.47 µM 1.2513569488017 0.0958884068871445 no 389 0.105402138362473 575 17682838 SGTC_1191 1487-1166 10.6 µM 1.24855187942603 0.0963855783731687 no 390 0.105914511007694 673 3955771 SGTC_339 3091-4833 71.4 µM 1.24518124477331 0.0969854933840171 no 391 0.106532567551061 577 3240077 SGTC_1161 k007-0610 110 µM 1.24446729620517 0.0971129149868197 no 392 0.106663814239812 691 5843850 SGTC_1440 4100-1550 40 µM 1.24425059635198 0.0971516146767088 no 393 0.106703673713288 532 742806 SGTC_1885 st057546 99.9 µM 1.24296058655443 0.0973822273878215 no 394 0.106941178829091 617 702008 SGTC_1675 st018485 24.5 µM 1.23849446612138 0.0981837292378041 no 395 0.107766386367552 588 3323024 SGTC_1438 4092-1045 4 µM 1.2369832046409 0.0984560355471585 no 396 0.108046658996339 594 1351342 SGTC_2690 usnic acid 100 µM 1.23620137613065 0.0985971259890042 no 397 0.108191859657247 668 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2032 5185112 25.99 µM 1.22842754077853 0.1000080680333 no 398 0.109643257270299 550 5718189 SGTC_1596 piperlongumine 63 µM 1.22689615598121 0.100287742322974 no 399 0.109930811771221 672 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_309 k408-0051 1.48 µM 1.22649782668945 0.10036058200982 no 400 0.110005696332533 688 3640463 SGTC_2482 5981709 142.65 µM 1.22441062235015 0.100742885675813 no 401 0.11039868207893 626 877755 SGTC_1307 1187-1599 12.2 µM 1.22352644851501 0.100905155604063 no 402 0.110565460428797 607 1538471 SGTC_2852 9023854 51.95 µM 1.22088084053175 0.10139183457978 no 403 0.111065569849398 615 19798528 SGTC_2767 sibutramine 71.45 µM 1.21847516297816 0.101835858941833 no 404 0.11152172876153 608 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1081 sertraline 6 µM 1.21819281219541 0.101888066085174 no 405 0.111575355233389 639 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1480 1070-0044 41.2 µM 1.21670271956895 0.102163909458969 no 406 0.111858671987016 608 3124987 SGTC_988 1497-1057 103 µM 1.21604186390036 0.102286419667114 no 407 0.111984487438482 618 3533044 SGTC_3226 9131256 49.47 µM 1.21202237221348 0.103033859661881 no 408 0.112751908422337 485 17178073 SGTC_1895 st058434 18.3 µM 1.21089101795457 0.103244953065472 no 409 0.112968587744617 640 5393175 SGTC_442 cape 100 µM 1.21040167807286 0.103336353625172 no 410 0.113062399154027 559 5281787 SGTC_3214 9129694 49.47 µM 1.2064455084721 0.104077458315385 no 411 0.113822878946655 576 17158655 SGTC_1701 st028638 40.4 µM 1.20528549774604 0.104295490648332 no 412 0.114046553076939 603 3490878 SGTC_2741 miltefosine 3.04 µM 1.19963009313646 0.105363206284973 no 413 0.115141516919384 507 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1965 Pectolinarigenin 58.4 µM 1.19928780604078 0.10542808143536 no 414 0.115208027459231 623 5320438 An anti-inflammatory. SGTC_3292 9120825 59.784 µM 1.19497923732845 0.106247175052972 no 415 0.116047571142545 636 24824900 SGTC_3076 9116187 49.47 µM 1.18968031846399 0.10726083216139 no 416 0.117086031948268 572 27241210 SGTC_3148 9097893 49.47 µM 1.18932102943751 0.107329813940918 no 417 0.117156681565734 600 17174100 SGTC_155 k072-0202 43.6 µM 1.18851323619389 0.107485023163327 no 418 0.117315634101882 600 5857737 SGTC_2330 7979373 200 µM 1.18394425908377 0.108365950907519 no 419 0.118217564300365 634 1863007 SGTC_3108 9121785 49.47 µM 1.183222538228 0.108505577054755 no 420 0.118360481449043 614 17140271 SGTC_3118 9124250 49.47 µM 1.18321088727844 0.108507832141277 no 421 0.118362789603472 559 1504786 SGTC_938 3126-1755 342 µM 1.18135941371663 0.108866620556809 no 422 0.118729986995346 676 1777771 SGTC_2263 7948595 193.29 µM 1.18109492886868 0.108917943383576 no 423 0.118782507130188 568 2971371 SGTC_495 decylubiquinone 155 µM 1.18101256829076 0.108933928862033 no 424 0.11879886524982 613 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_919 tnp00227 403.569 nM 1.17952449334804 0.109223041952872 no 425 0.119094694721609 678 1269246 A methoxyflavone. YNL221C POP1 SGTC_1315 1237-0019 3.69 µM 1.17906838901975 0.109311767221985 no 426 0.119185472361225 665 825140 SGTC_320 4092-0846 5.34 µM 1.17890428301934 0.109343703170969 no 427 0.119218146034009 643 1359356 SGTC_2408 sulbentine 18.36 µM 1.17755897919771 0.109605759552118 no 428 0.119486235771007 627 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_2692 st077426 47.7 µM 1.17164117351068 0.110763864029242 no 429 0.120670575075737 671 25238571 SGTC_1215 3852-0577 11.2 µM 1.1680519044994 0.111470535486045 no 430 0.121392914427624 716 2884876 SGTC_2883 9059145 45.46 µM 1.16543454068765 0.111987884215276 no 431 0.121921571310959 609 16476510 SGTC_3096 9117468 49.47 µM 1.16464778415939 0.11214372974343 no 432 0.122080796559087 532 41316311 SGTC_1065 prochlorperazine maleate 2.48 µM 1.16342735119207 0.112385787194771 no 433 0.12232807889034 669 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_761 k216-0224 480 µM 1.16338947792085 0.112393304846707 no 434 0.122335758337158 701 1340404 SGTC_318 1488-0629 67.2 µM 1.15993761141779 0.113079992146199 no 435 0.123037104041215 614 3662576 SGTC_414 piperonyl butoxide 100 µM 1.15866813943266 0.113333282421009 no 436 0.123295741224963 646 5794 A potent inhibitor of cytochrome P450. SGTC_2589 lobaric acid 100 µM 1.15550195245751 0.113966775720778 no 437 0.123942466766249 644 73157 A novel microtubule depolymerizer. SGTC_2504 purpurogallin 52.29 µM 1.15523150706771 0.114021003378942 no 438 0.123997817810176 619 5281571 An antioxidant. SGTC_486 niguldipine 82 µM 1.15495463776947 0.114076538150264 no 439 0.124054501528358 591 1236 A calcium channel blocker. SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.15368140421724 0.114332172881736 no 440 0.124315405258748 585 77254 SGTC_2027 5150920 200 µM 1.15295009421955 0.11447918666144 no 441 0.124465434513799 660 786715 SGTC_2384 9036245 200 µM 1.14987324471343 0.115099193499019 no 442 0.125098041050465 677 6462766 SGTC_1338 1486-1223 76 µM 1.14548350845761 0.115987883682558 no 443 0.126004461544 709 3444526 SGTC_133 0724-0033 378.92 µM 1.14506085937367 0.116073704225572 no 444 0.126091973859098 622 280309 SGTC_941 3237-0776 460 µM 1.1442042680935 0.116247776645892 no 445 0.126269466741479 631 760008 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.14366680446634 0.116357091990076 no 446 0.126380922564047 717 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_266 formosanin C 406 nM 1.14159149821122 0.116779875333541 no 447 0.126811929786544 684 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1489 4065-0444 182 µM 1.14153216399717 0.11679197894783 no 448 0.126824267563647 646 2877968 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.14059652512101 0.116982957951678 no 449 0.127018931982006 567 1241132 A phosphatase inhibitor. SGTC_2329 6138490 200 µM 1.13906282495187 0.117296489442938 no 450 0.1273384757195 589 720019 SGTC_208 k072-0098 12.366 µM 1.13465912418865 0.118200036224817 no 451 0.128259085093938 761 5948901 SGTC_1071 trifluoperazine 6.31 µM 1.13350040918575 0.118438595900895 no 452 0.128502084728181 690 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_199 4063-0024 41.6 µM 1.12906236572831 0.11935546075754 no 453 0.129435762894506 701 306215 SGTC_439 amiodarone 34.4 µM 1.12818141043714 0.119538053375116 no 454 0.129621656532119 701 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_79 0052-0007 94.094 µM 1.1272324106598 0.119734969715002 no 455 0.129822115304772 695 2801472 SGTC_1249 0481-0015 10.2 µM 1.12604511973713 0.119981653158542 no 456 0.13007321083978 613 4227577 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.1255444167508 0.120085791541199 no 457 0.130179203264123 676 756377 SGTC_1522 st012842 45.6 µM 1.124555752834 0.120291605187276 no 458 0.130388666258012 626 3491067 YOR116C RPO31 SGTC_3297 9117502 71.43 µM 1.12317498216834 0.120579460759171 no 459 0.130681592803974 684 7453720 SGTC_1456 k015-0012 13 µM 1.12292874629034 0.120630845595309 no 460 0.13073387880418 767 2989616 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.1199394196498 0.12125589221647 no 461 0.131369789284158 680 390807 SGTC_2834 9001755 58.44 µM 1.11655360733977 0.121966587822676 no 462 0.132092618576383 626 2989575 SGTC_2570 licareol 100 µM 1.11652225009579 0.121973183478812 no 463 0.132099325754424 676 443158 SGTC_2348 9022543 33.42 µM 1.11470247052424 0.122356383570184 no 464 0.132488970996522 708 3162678 YDL140C RPO21 SGTC_2762 leflunomide 42.06 µM 1.11459000958979 0.122380092723898 no 465 0.13251307671898 718 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1329 1447-1697 50.6 µM 1.11445428280289 0.122408711107181 no 466 0.132542173443404 691 2840515 SGTC_3016 9080866 49.47 µM 1.11257808452698 0.122804794160363 no 467 0.132944838532135 723 17066299 SGTC_2305 7443522 69.23 µM 1.11159649034824 0.123012375648525 no 468 0.133155841114451 739 5415886 SGTC_1063 disulfiram 1.84 µM 1.10650763279807 0.124092478774801 no 469 0.134253431076767 683 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2463 5473429 200 µM 1.10508369945949 0.124395891268646 no 470 0.134561661532498 680 5399405 SGTC_1491 4138-0063 26.5 µM 1.10334311073762 0.124767481017975 no 471 0.134939095847427 669 23883227 SGTC_2699 st077704 54.6 µM 1.09866193981332 0.125770687208779 no 472 0.135957774813264 692 645852 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.09362087808801 0.126857297567362 no 473 0.137060644297901 694 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1663 st014140 55.4 µM 1.0906378623451 0.127503361564923 no 474 0.137716131198818 818 4207120 SGTC_563 tetrahydrosecaminediol 614 µM 1.08887318403947 0.127886632341657 no 475 0.138104906533365 754 334274 A psychoactive constituent of the cannabis plant. SGTC_1058 3448-5425 97.3 µM 1.08701690470425 0.128290661149839 no 476 0.138514669429082 689 7279705 SGTC_1946 st076057 65.1 µM 1.08642212075905 0.128420306245004 no 477 0.13864613960701 587 953009 SGTC_473 2-arachidonoylglycerol 10 µM 1.08383644721105 0.128984962628212 no 478 0.139218660968808 699 5282280 An endocannabinoid. SGTC_2636 apigenin dimethyl ether 100 µM 1.07876179679165 0.130098158688118 no 479 0.140346964711668 729 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2095 5432005 200 µM 1.07473399009752 0.130986434938623 no 480 0.141246920667057 691 783734 SGTC_72 0744-0168 198.391 µM 1.07336087894874 0.131290210921524 no 481 0.141554615007412 700 677577 SGTC_3277 9138724 49.47 µM 1.07193681394688 0.131605773071613 no 482 0.141874206771438 631 15943418 SGTC_2784 7567673 72.73 µM 1.07014390663695 0.13200381178277 no 483 0.142277269231048 761 3471247 SGTC_992 3909-8734 162 µM 1.07006701925297 0.132020899897825 no 484 0.14229457154802 710 4288319 SGTC_2219 9098279 200 µM 1.06964599995164 0.132114497904385 no 485 0.142389340673091 723 902349 SGTC_755 1995-0008 37.3 µM 1.06928657511935 0.132194438863687 no 486 0.142470278999571 762 689533 SGTC_103 0844-0104 51.839 µM 1.0677260974858 0.132541896912838 no 487 0.142822041352739 834 5375804 SGTC_2364 9055074 200 µM 1.06545866931866 0.133047886026018 no 488 0.143334209683629 700 6470630 SGTC_1941 st076221 61.8 µM 1.06030663938692 0.134202528034878 no 489 0.144502559851014 782 2828568 SGTC_1996 st072960 66.8 µM 1.05918494478487 0.134454825147213 no 490 0.144757780065746 783 1719405 SGTC_2439 5492030 7.2 µM 1.058876457866 0.13452426861148 no 491 0.14482802357396 726 5722370 SGTC_1010 4112-3296 15.2 µM 1.05470846395751 0.135464939219462 no 492 0.1457793397941 783 704384 SGTC_1145 3546-0597 10.2 µM 1.05185763411069 0.136110930302291 no 493 0.146432435915641 765 875334 SGTC_2144 5628481 200 µM 1.04442894317957 0.137804147183488 no 494 0.148143489262242 730 2818399 SGTC_948 3448-0295 75.3 µM 1.04385860310849 0.137934735917496 no 495 0.148275406687073 798 678569 SGTC_217 ketoconazole 989 nM 1.04257346903783 0.138229297812356 no 496 0.148572941117537 747 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_164 4100-3994 89.624 µM 1.04247927161257 0.138250905390673 no 497 0.148594765410358 826 4615967 SGTC_3106 9121286 49.47 µM 1.04200069556711 0.138360719641409 no 498 0.148705678231639 701 15943471 SGTC_3162 9099653 49.47 µM 1.04027159704209 0.138757974642653 no 499 0.149106868061941 703 25237511 SGTC_166 k072-0058 166.424 µM 1.03911550921806 0.13902401514929 no 500 0.149375509392908 775 5846229 SGTC_1372 2752-0194 270 µM 1.03754060528809 0.139386992578492 no 501 0.149741991042294 718 823334 SGTC_2125 5246583 200 µM 1.03678044465314 0.139562421788487 no 502 0.149919095597235 864 835267 SGTC_2754 granisetron 64.02 µM 1.03501716912332 0.139969926888102 no 503 0.150330446555031 762 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_996 3970-0799 1.8 µM 1.03329956521932 0.140367653667602 no 504 0.150731865338694 949 6615648 YGL040C HEM2 SGTC_2343 7990716 14.84 µM 1.03278574778634 0.140486781739565 no 505 0.150852087444782 786 6456862 SGTC_2552 juarezic acid 87.02 µM 1.0327787174204 0.140488412198926 no 506 0.150853732840075 908 1549512 SGTC_958 1222-0007 33 µM 1.03192808572236 0.140685782721618 no 507 0.15105290387818 820 7312461 SGTC_636 0kpi-0074 126 µM 1.03099786421028 0.140901835638884 no 508 0.151270910683106 733 616434 SGTC_2565 isoliquiritigenin 100 µM 1.0291481632049 0.141332114994942 no 509 0.151705028322122 615 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2876 9059903 25.97 µM 1.02557672595101 0.142165424158388 no 510 0.152545571300546 824 6916095 SGTC_3300 9124615 50.48 µM 1.02417715729521 0.142492884937875 no 511 0.152875802978749 769 24824903 SGTC_140 0062-0056 502.533 µM 1.02307932949897 0.142750103364306 no 512 0.153135169669447 828 3758964 SGTC_1511 0906-3109 28.5 µM 1.02203114134098 0.142995984087615 no 513 0.153383080779068 859 2882180 SGTC_922 1866-0035 480 µM 1.02131614066749 0.143163870814419 no 514 0.15355234085418 881 3156169 SGTC_2645 abamectin 100 µM 1.01531491163653 0.144578245665212 no 515 0.154977869256465 760 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1155 4088-0394 48.2 µM 1.01503145353299 0.144645283335492 no 516 0.155045417191932 767 2326248 SGTC_1561 5-methoxyflavone 52.9 µM 1.01277839490715 0.145178874922964 no 517 0.155583011303718 753 94525 SGTC_2387 9077560 195.08 µM 1.01069110053567 0.145674389149462 no 518 0.156082148908289 784 5303272 SGTC_2089 5281248 129.67 µM 1.01041289106889 0.145740520590004 no 519 0.156148757135814 795 2737878 SGTC_2988 9073640 71.4286 µM 1.00756126441482 0.146419526484624 no 520 0.156832566299098 749 9102229 SGTC_93 0109-0045 59.227 µM 1.00209191724055 0.147727776956522 no 521 0.158149600646932 943 88733 SGTC_465 cgp-37157 41 µM 1.00146444249738 0.147878365925939 no 522 0.158301161183475 691 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1051 3253-3903 78 µM 1.00051267539191 0.148106978595849 no 523 0.158531233294748 823 5509239 SGTC_2825 7998094 58.44 µM 1.00048083015129 0.148114631849672 no 524 0.158538935082907 754 2987815 SGTC_57 miconazole 162.5 nM 1.00024967635135 0.148170192155452 no 525 0.158594847105846 760 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2346 9031566 143.75 µM 0.998997145647438 0.148471493889503 no 526 0.158898037002731 810 4771086 SGTC_1824 st053723 68.6 µM 0.998352222326316 0.148626792698095 no 527 0.159054296384835 809 675225 SGTC_2584 androsterone 48.74 µM 0.998099254016162 0.148687737608185 no 528 0.159115615914217 955 2754130 A steroid. SGTC_532 1548-0774 215 µM 0.996303035367278 0.149120961460033 no 529 0.159551464711574 842 5932993 SGTC_2327 6189656 200 µM 0.992605835762969 0.150015327554819 no 530 0.160451039861879 808 5349088 SGTC_2347 9049783 174.81 µM 0.992572889852898 0.150023313334597 no 531 0.160459070883723 845 6467988 YPL169C MEX67 SGTC_911 3456-4043 236 µM 0.990016364505103 0.150643855500707 no 532 0.161083060216083 837 914281 SGTC_3202 9113761 49.47 µM 0.989500112778392 0.150769371773138 no 533 0.161209257353895 879 4798415 SGTC_2499 avocadenofuran 51.48 µM 0.987006813034937 0.151376547655346 no 534 0.161819649319641 763 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1415 3966-0071 78.1 µM 0.984113061488441 0.152083278876568 no 535 0.162529962743074 822 2893185 SGTC_713 1488-1073 324 µM 0.983641822727846 0.152198575076565 no 536 0.162645826957972 832 3312542 SGTC_123 0083-0120 66.675 µM 0.982193925448646 0.152553189624912 no 537 0.163002159827548 798 16001701 SGTC_183 3914-0051 30.55 µM 0.981995102197701 0.152601927578303 no 538 0.163051130563466 837 1596232 SGTC_547 1120-0019 610 nM 0.978610886680308 0.153433091623485 no 539 0.163886139037714 806 3676939 SGTC_2325 6158266 200 µM 0.978408945387912 0.153482783074268 no 540 0.163936052844935 787 3623240 SGTC_806 3966-4455 5.86 µM 0.976161430883706 0.154036545662541 no 541 0.164492236473917 726 714982 SGTC_2571 chrysanthemic acid 100 µM 0.974695744056553 0.154398385834165 no 542 0.164855602344063 770 2743 An insecticide. SGTC_663 1486-0733 13.9 µM 0.969126832200959 0.155778326262502 no 543 0.166240955780736 857 722445 YPR165W RHO1 SGTC_2533 agelasine 13.65 µM 0.968494239696706 0.155935591377394 no 544 0.166398797223158 861 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1117 retinoic acid 1.10837 µM 0.965296734315758 0.156732105335117 no 545 0.167198103513147 898 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_454 lyso-paf C-16 6.67 µM 0.965291071649962 0.156733518303488 no 546 0.167199521247508 870 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_3313 9133968 57.047 µM 0.964395343239764 0.156957129168379 no 547 0.167423878018044 883 1494643 SGTC_3073 9114972 49.47 µM 0.964172417765739 0.157012813188572 no 548 0.167479745208998 779 41905075 SGTC_2021 4019055 173 µM 0.962443716492712 0.157445062386856 no 549 0.167913381410879 930 44827708 YER133W GLC7 SGTC_2393 9031399 185.94 µM 0.959206268389156 0.158256664612777 no 550 0.168727421631846 851 1526623 YDL150W RPC53 SGTC_341 1486-1430 230 µM 0.956121416599044 0.159032561896215 no 551 0.169505447917196 820 2054753 YPL210C SRP72 SGTC_686 1319-0111 510 µM 0.955899317499732 0.159088519947426 no 552 0.169561551923928 886 4562600 SGTC_579 4491-1009 110 µM 0.955261725886633 0.159249233338896 no 553 0.169722678843079 1057 1271041 SGTC_892 0929-0076 29 µM 0.955231729590646 0.159256796919626 no 554 0.169730261678671 863 5751038 SGTC_827 3253-0474 693 µM 0.954830569712994 0.159357972191143 no 555 0.169831692729253 895 5402065 SGTC_974 1326-0144 138 µM 0.954243086943974 0.159506215303928 no 556 0.169980304613444 863 5411856 SGTC_2997 9067075 71.4286 µM 0.951660379260684 0.160158996079748 no 557 0.170634624631277 869 27209819 SGTC_943 3253-1379 105 µM 0.949965643050515 0.16058828925178 no 558 0.171064855145099 844 668464 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.949763230916982 0.160639612414269 no 559 0.171116286403423 815 689007 SGTC_687 k029-0044 34.9 µM 0.948960161797117 0.160843342358777 no 560 0.171320437101292 920 5829338 SGTC_1201 1889-3372 45.9 µM 0.948343998712472 0.160999770579259 no 561 0.171477179354476 833 5392199 SGTC_100 0086-0128 49.5915 µM 0.947465248650602 0.161223034712917 no 562 0.171700878128775 890 93297 SGTC_2974 9094440 9.66 µM 0.946553961752432 0.161454778717636 no 563 0.171933056435833 869 25236134 SGTC_2780 5215298 71.43 µM 0.946020038132917 0.161590658554089 no 564 0.172069182951632 903 2834131 SGTC_3054 9094397 49.47 µM 0.945993004639934 0.161597540371706 no 565 0.172076077106111 876 2598354 SGTC_665 3914-0008 307 µM 0.94459526000286 0.161953619432213 no 566 0.172432773935254 830 1069549 SGTC_2186 6124449 200 µM 0.943658719406245 0.162192491322458 no 567 0.17267203767252 858 3834182 YLR033W RSC58 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.942809939843635 0.16240917714935 no 568 0.172889063305787 946 551469 SGTC_2954 9074818 52.69 µM 0.942628069694924 0.162455631470391 no 569 0.172935588541528 832 16648742 SGTC_863 0466-0191 129 µM 0.940797414279076 0.162923709548743 no 570 0.173404343117463 905 765160 YPR165W RHO1 SGTC_2802 7925815 54.55 µM 0.939681054854978 0.163209580119804 no 571 0.173690592874864 842 1262923 SGTC_1925 st057770 10.1 µM 0.939555033299786 0.163241871419243 no 572 0.173722925390425 777 5989122 SGTC_776 4476-4378 112 µM 0.939271195312031 0.163314616223733 no 573 0.173795761844778 822 2892008 SGTC_2891 9063876 19.48 µM 0.938313088776605 0.163560324738193 no 574 0.174041767640904 819 6472478 SGTC_1755 st041960 45.185 µM 0.937448589163123 0.163782233458689 no 575 0.174263928583757 855 2257073 SGTC_1719 st032227 49.2 µM 0.93235335234488 0.16509409951572 no 576 0.175576971872471 863 3125804 SGTC_1106 tegaserod maleate 11.7 µM 0.931967330249313 0.165193764725991 no 577 0.175676704674012 896 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1659 st012954 42.1 µM 0.93084689422963 0.165483265279137 no 578 0.175966384147334 862 24207262 SGTC_2667 digitoxin 100 µM 0.928644383570478 0.166053310539205 no 579 0.176536706173926 845 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_993 3909-8757 62.7 µM 0.928270825083739 0.16615011919267 no 580 0.176633551902736 802 4288324 YLR208W SEC13 SGTC_1206 3978-0017 132 µM 0.927758001285329 0.166283078183718 no 581 0.176766557126387 824 3873677 SGTC_2920 7982904 15.77 µM 0.923329824212331 0.167434021800474 no 582 0.177917675059443 822 6456808 SGTC_936 3005-4620 401 µM 0.919734208118741 0.168372338402585 no 583 0.178855835882784 942 777207 SGTC_774 k060-0086 136 µM 0.916013978795327 0.169346726743257 no 584 0.179829781572158 961 5911235 SGTC_1100 amiodarone 5.07 µM 0.914751986481924 0.169678083469207 no 585 0.180160922949433 950 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1402 3909-7673 35.9 µM 0.914698441855215 0.169692151677497 no 586 0.180174981289354 875 5328014 SGTC_2041 5107442 45.335 µM 0.913414786037113 0.170029640786121 no 587 0.180512215981096 906 793005 SGTC_354 2783-3500 4.88 µM 0.912613242572862 0.170240594589888 no 588 0.180722993542573 853 6740761 SGTC_3225 9130819 49.47 µM 0.912611791965278 0.170240976519245 no 589 0.180723375140854 905 4547121 SGTC_1084 voriconazole 435 nM 0.911750999276019 0.170467710779347 no 590 0.18094990521386 929 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_902 1120-0002 2.07 µM 0.911047174637417 0.170653243021722 no 591 0.181135259035461 897 3280475 SGTC_1942 st076330 65.2 µM 0.909992423420596 0.170931523450131 no 592 0.181413252752073 917 24208414 SGTC_2479 5617353 43.85 µM 0.90744772431099 0.171604098889013 no 593 0.182085040895061 881 2731746 SGTC_2829 7992743 58.44 µM 0.904752178944473 0.172318385203361 no 594 0.182798345593847 922 16462845 SGTC_1413 3910-0535 34.4 µM 0.904200368642795 0.172464841698931 no 595 0.18294458237992 948 2876951 SGTC_1086 cerivastatin 2.18 µM 0.904102423196755 0.172490845786656 no 596 0.182970546802638 896 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_96 0929-0093 37.281 µM 0.903756366946408 0.172582742231884 no 597 0.183062301494707 869 6991579 SGTC_1705 st027868 56.3335 µM 0.902345955683929 0.172957604689641 no 598 0.183436560231521 937 292948 SGTC_269 exalamide 29 µM 0.898529958736571 0.173974427741261 no 599 0.184451540373984 895 3316 A derivative of salicylamide. SGTC_1309 pyrazolanthrone 13.4 µM 0.896410231539302 0.174540895890123 no 600 0.185016852392226 971 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1428 4049-0204 61.7 µM 0.895107289779738 0.174889669907492 no 601 0.185364868739329 956 X1428 SGTC_2030 5175110 200 µM 0.89284343292247 0.175496714609582 no 602 0.185970511714336 914 2831986 SGTC_1296 1068-0102 11.9 µM 0.891053355557879 0.175977661463322 no 603 0.186450273446268 917 767053 SGTC_3190 9110366 49.47 µM 0.888804283745063 0.176583109877923 no 604 0.187054136628853 844 17123768 SGTC_823 0417-1665 178 µM 0.88807674450159 0.176779244543467 no 605 0.187249735527919 936 3429856 SGTC_40 0327-0103 19.753 µM 0.886761936307216 0.177134048085699 no 606 0.187603542321328 886 409036 SGTC_1560 lithocholic acid 53.1 µM 0.884760835428149 0.177674911670072 no 607 0.188142818355261 879 9903 A bile acid which acts as a detergent. SGTC_749 1000-0129 128 µM 0.884614024752784 0.177714633089447 no 608 0.188182419949504 991 708470 SGTC_2709 st078560 56 µM 0.883659249250159 0.177973095934609 no 609 0.188440092320768 943 17250903 SGTC_1657 st012939 43.4 µM 0.882315189303583 0.178337341647233 no 610 0.188803192349919 898 24207257 SGTC_1405 3909-7894 12 µM 0.881225933333587 0.178632878784495 no 611 0.18909777274087 944 7104060 SGTC_1169 aniline yellow 25.8 µM 0.877986532939676 0.17951361461679 no 612 0.189975513540491 907 6051 A DNA damaging agent. SGTC_989 1501-0895 10.3 µM 0.877398336819272 0.179673827074733 no 613 0.190135158107628 965 2830112 SGTC_1856 st057054 55.7 µM 0.876862998842856 0.179819720138946 no 614 0.190280527878297 968 1266018 SGTC_1656 st012921 11 µM 0.875218737512645 0.18026828781688 no 615 0.190727449913811 874 6732821 SGTC_2054 5233173 129 µM 0.875066234436966 0.180309927434967 no 616 0.190768933965031 939 6889 SGTC_2968 9090663 33.37 µM 0.874287514067168 0.180522644237679 no 617 0.190980848628886 899 25236811 SGTC_1504 k297-0033 30 µM 0.872514025952075 0.181007680916206 no 618 0.191464009930644 822 4388117 SGTC_58 0957-0393 9 µM 0.872019503135381 0.181143074932067 no 619 0.191598868972834 1022 6997992 SGTC_1285 0929-0069 65.5 µM 0.871659556457479 0.181241663606089 no 620 0.191697064953672 927 1206237 SGTC_705 1124-0212 310 µM 0.870311164815604 0.181611284030707 no 621 0.192065189559657 950 9554485 SGTC_2748 diazoxide 86.69 µM 0.868878557786191 0.182004505972066 no 622 0.1924567794114 873 3019 A potassium channel activatior. SGTC_1017 4239-0030 168 µM 0.868219819450694 0.182185494991404 no 623 0.192637003138694 917 1149593 SGTC_3048 9093155 49.47 µM 0.867226939704752 0.182458502173501 no 624 0.192908839175821 919 25236002 SGTC_1617 st002906 78 µM 0.865651848032398 0.182892121223155 no 625 0.193340556738199 970 5150859 SGTC_871 0574-0004 149 µM 0.865089191120178 0.183047175133679 no 626 0.193494918422117 937 9551173 SGTC_68 0986-0284 82.829 µM 0.86416196900237 0.183302872803444 no 627 0.193749460436171 782 423278 YIL048W NEO1 SGTC_718 1130-0073 349 µM 0.86224899122383 0.183831113139706 no 628 0.194275257816922 971 6740020 SGTC_84 0443-0269 128.823 µM 0.86188872883255 0.183930700229327 no 629 0.194374375983119 966 6150058 SGTC_2275 7947463 200 µM 0.857730250053641 0.185082656581628 no 630 0.195520716178803 951 1225414 SGTC_1944 st076371 56.9 µM 0.856982320931202 0.185290317861598 no 631 0.195727327587815 896 24208455 SGTC_3047 9092122 49.47 µM 0.855693942148275 0.185648373188923 no 632 0.196083545943018 934 17173831 SGTC_407 eburnamonine 100 µM 0.855560269408287 0.18568554695073 no 633 0.196120527050308 910 3195 SGTC_865 0488-0499 301 µM 0.855389855030255 0.185732945085653 no 634 0.196167679014397 1024 9634651 SGTC_1147 3809-1045 12.3 µM 0.853959681457121 0.186131021586473 no 635 0.196563664698676 935 325925 SGTC_2071 5230951 39.92 µM 0.852245791457414 0.186608764114372 no 636 0.19703884305168 1052 1799272 SGTC_2486 5283202 22.39 µM 0.850981083783765 0.186961784589425 no 637 0.19738993038709 899 1377751 SGTC_1406 3909-7906 11.9 µM 0.850077479634088 0.18721426238816 no 638 0.197641005664666 977 X1406 SGTC_3081 9117243 49.47 µM 0.849365597363923 0.187413319210054 no 639 0.197838945012813 981 45595589 SGTC_2469 5655019 90.81 µM 0.848696925730025 0.187600412560287 no 640 0.198024978654834 1041 2788239 SGTC_444 curcumin 90.4 µM 0.848499524925025 0.187655667073404 no 641 0.19807991846346 934 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2373 9071805 200 µM 0.848355669426042 0.18769594003784 no 642 0.198119961552055 1004 10149009 SGTC_1487 3970-0795 2.82 µM 0.848073116453568 0.187775057496098 no 643 0.198198626186591 996 3765103 SGTC_2033 5192550 145 µM 0.847100806024074 0.188047470813668 no 644 0.198469467950316 966 182073 SGTC_2465 5809242 33.21 µM 0.846937383251883 0.188093281092348 no 645 0.198515012061393 989 2731748 SGTC_2025 5147754 141 µM 0.846609391640434 0.188185243695095 no 646 0.198606438702474 978 315777 YLR208W SEC13 SGTC_2958 9077254 16.72 µM 0.846605177476131 0.188186425447031 no 647 0.198607613552878 958 16457351 SGTC_404 fumagillin 50 µM 0.844604676876862 0.188747930394886 no 648 0.199165798470296 981 12015870 A methionine aminopeptidase binder. SGTC_1635 st007035 42.4 µM 0.84207279287328 0.189460063932282 no 649 0.19987360461468 1039 3716403 SGTC_2077 5212015 200 µM 0.841629700212284 0.189584860733172 no 650 0.199997629671828 935 780900 SGTC_2137 5261020 140 µM 0.840827349688153 0.189810970978002 no 651 0.200222331500682 956 763655 SGTC_192 3455-0609 60.9 µM 0.840197249252098 0.189988655656383 no 652 0.20039890023465 977 3769639 SGTC_2944 9067346 25.62 µM 0.839232845486021 0.190260809863565 no 653 0.20066932956983 909 6473075 SGTC_3261 9137475 49.47 µM 0.839118879498717 0.19029298681758 no 654 0.200701301343778 821 17027690 SGTC_767 0929-0023 86 µM 0.836187773224159 0.191121698338656 no 655 0.201524637863682 1045 1204563 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.835258087336073 0.191385009950859 no 656 0.20178620521872 1042 16623 A steroid. SGTC_2363 9053361 176 µM 0.834830508712055 0.19150618611548 no 657 0.201906572790829 1001 6469797 YMR079W SEC14 SGTC_2745 rifampicin 24.3 µM 0.833666856412245 0.191836204178229 no 658 0.202234369913845 871 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2517 totarol 10 µM 0.832416147220747 0.19219130000537 no 659 0.202587045423329 958 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2882 9058044 58.44 µM 0.831947036505424 0.192324591472382 no 660 0.202719420207096 1002 18076804 SGTC_1297 1068-0111 14.1 µM 0.829360776355933 0.193060456850217 no 661 0.203450144758239 966 767057 SGTC_2626 ethyl orsellinate 100 µM 0.829072439816904 0.193142603266449 no 662 0.20353170889871 987 75653 A natural product. SGTC_2670 beta-carotene 100 µM 0.828939735645324 0.193180417548524 no 663 0.203569254577653 950 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2595 hexamethylquercetagetin 100 µM 0.828918114163666 0.193186579055045 no 664 0.203575372283883 927 386331 SGTC_2940 9060638 45.86 µM 0.828112176152823 0.193416334000709 no 665 0.203803487221743 964 4027022 SGTC_694 1315-0438 43.2 µM 0.8280220410339 0.193442039872856 no 666 0.203829008786318 931 6793154 SGTC_3294 9122953 26.2835 µM 0.824472087676691 0.1944561173137 no 667 0.204835684630168 1067 16459826 SGTC_1967 st070177 51.4 µM 0.824094014323525 0.194564307849764 no 668 0.204943070480239 1000 5729214 SGTC_1648 st011736 69.8 µM 0.823452347264859 0.194748012928481 no 669 0.205125402608315 997 2855514 SGTC_1940 st075990 51.1 µM 0.822330154172967 0.195069542983561 no 670 0.205444509653722 1083 1084979 SGTC_1520 flindersine 88 µM 0.821971511124367 0.195172369169581 no 671 0.205546555590197 1041 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_732 3970-1727 52.7 µM 0.821616814902455 0.195274096157807 no 672 0.205647508114724 1015 1275699 SGTC_1282 0886-0010 32.4 µM 0.821584889596378 0.195283253925749 no 673 0.20565659603851 1089 2836211 YNL267W PIK1 SGTC_3062 9077494 49.47 µM 0.820805608800705 0.195506871388908 no 674 0.205878501640993 979 16459633 SGTC_1380 2291-0730 164 µM 0.820803488323379 0.195507480079671 no 675 0.205879105655315 967 2999191 SGTC_69 0096-0274 206.684 µM 0.820089205477725 0.195712583063296 no 676 0.206082627711262 1124 6741392 SGTC_877 0771-0151 33.1 µM 0.820032319876288 0.195728923111404 no 677 0.206098841368044 1017 6166523 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.819509579856923 0.195879115814229 no 678 0.206247869263091 1023 2333 A French combination drug. SGTC_629 3448-6466 76.7 µM 0.819472708613227 0.195889712231968 no 679 0.206258383292953 1032 573744 SGTC_3132 9126706 49.47 µM 0.817968243572805 0.196322376665453 no 680 0.206687660330572 964 850858 SGTC_3230 9131665 49.47 µM 0.81796555247293 0.196323151109193 no 681 0.206688428670161 960 15943720 SGTC_2608 thymoquinone 42.66 µM 0.815948503804501 0.196904137415853 no 682 0.207264794559909 963 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_633 0437-0093 97.7 µM 0.815632202587019 0.196995338451049 no 683 0.207355262858241 1045 2831118 SGTC_2737 bleomycin 30.5 nM 0.814950914168961 0.197191865273551 no 684 0.207550203875185 1072 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3299 9121982 43.1275 µM 0.810518531335692 0.198473339750621 no 685 0.208821109388729 1034 17594604 YPL160W CDC60 SGTC_1055 3448-0672 86 µM 0.808318735861403 0.199111197863749 no 686 0.209453559792077 980 748378 SGTC_1655 st012546 55.1 µM 0.808282732459865 0.199121647759933 no 687 0.209463920285357 973 720985 YLR208W SEC13 SGTC_2215 7188065 200 µM 0.806075595364171 0.199762894501556 no 688 0.210099631132842 1031 940217 SGTC_1026 k007-1105 30.6 µM 0.806033210319186 0.199775220911504 no 689 0.210111850170558 1032 7066794 SGTC_2828 7998861 71.43 µM 0.804720215374304 0.200157292405713 no 690 0.210490575660234 959 2988188 SGTC_2460 5552655 174.22 µM 0.802304429978363 0.200861413854159 no 691 0.211188440247719 1040 5401989 SGTC_2681 menadione 3.18 µM 0.80180801595853 0.201006285984828 no 692 0.21133201052704 1039 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_572 0960-0087 17.7 µM 0.801676804274623 0.201044588920221 no 693 0.211369968438289 1098 6796365 SGTC_273 hydroxyurea 18.1 mM 0.801341681454155 0.201142436873378 no 694 0.2114669334321 1101 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_2973 9094665 17.96 µM 0.798068960581216 0.202099494546566 no 695 0.212415236359459 1079 25237061 YIL048W NEO1 SGTC_2783 7738165 71.43 µM 0.797966572364662 0.202129480323448 no 696 0.212444944375866 956 17201110 SGTC_1743 st037606 46.3785 µM 0.796727948798256 0.202492438873625 no 697 0.212804524177308 1016 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1430 4049-0248 69.1 µM 0.796276484198839 0.20262483008994 no 698 0.212935675335382 1117 22774488 SGTC_1973 st070275 50.2 µM 0.795939533685989 0.202723673954184 no 699 0.213033590707673 1021 17118334 SGTC_987 1497-1013 404 µM 0.795229503270755 0.2029320544813 no 700 0.213240006367821 1063 1676435 SGTC_2149 5554786 194.827 µM 0.791148295331405 0.204132290890761 no 701 0.214428729701747 1086 745063 YPR165W RHO1 SGTC_382 3229-0966 23.2 µM 0.79055176128842 0.204308078204714 no 702 0.214602802899715 1070 5722370 SGTC_3195 9113082 49.47 µM 0.788653176395278 0.204868154906783 no 703 0.215157370923642 1027 17018038 SGTC_1038 k292-0204 154 µM 0.787721758668448 0.20514325375154 no 704 0.215429737692778 1007 4454212 SGTC_2785 7756463 72.73 µM 0.787005672830119 0.20535490243961 no 705 0.215639272672683 1090 2201551 SGTC_820 1582-0060 59.9 µM 0.786969491965869 0.205365599615965 no 706 0.215649862746251 1026 3848840 SGTC_631 k072-0230 41.5 µM 0.786907605219219 0.205383897719523 no 707 0.215667977584131 1080 5773147 SGTC_1496 4469-0713 57.4 µM 0.786869071505689 0.20539529150237 no 708 0.215679257213323 1045 746691 SGTC_2094 5332512 191.667 µM 0.786538411442551 0.205493077654153 no 709 0.215776062433928 1098 755774 SGTC_975 1335-0046 28.5 µM 0.786308425375256 0.205561107766464 no 710 0.215843408823843 1072 16486740 SGTC_2965 9082772 38.63 µM 0.781019855346219 0.207129157933897 no 711 0.217395408430199 1106 16459634 SGTC_223 busulfan 5 mM 0.780057146300856 0.207415358533818 no 712 0.217678619516795 1004 2478 A DNA alkylator. SGTC_1734 st037168 69.4 µM 0.779012279491999 0.207726247943488 no 713 0.217986240658146 993 708907 SGTC_2910 7948405 25.97 µM 0.778216190515262 0.207963300712696 no 714 0.21822078680395 1049 2971328 SGTC_3351 9150312 21.596 µM 0.777927615132922 0.208049269720613 no 715 0.218305843654665 1070 4904905 SGTC_2843 9000894 45.46 µM 0.774215992923157 0.209156861668792 no 716 0.219401536118391 967 2242070 SGTC_1683 st010134 710 nM 0.774117204254616 0.209186388727341 no 717 0.219430742213168 1106 3818134 SGTC_864 0469-0573 172 µM 0.773717569855205 0.209305860952717 no 718 0.219548913780723 1025 689425 SGTC_1274 0865-0114 173 µM 0.77167127284717 0.209918238217835 no 719 0.220154574623064 1072 870624 SGTC_717 1532-0246 73.2 µM 0.771214593644555 0.210055048160618 no 720 0.220289872730126 1056 9561992 SGTC_2513 baicalein 25.65 µM 0.770487021651553 0.210273119151757 no 721 0.220505525362048 1084 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2136 5328288 199.296 µM 0.768894418085223 0.210750924847166 no 722 0.220977995687049 1005 262395 SGTC_288 1315-0019 35.1 µM 0.768538653213329 0.210857746766487 no 723 0.221083617926397 1093 6811474 SGTC_1998 st075797 76.8 µM 0.768487941053442 0.2108729761789 no 724 0.221098676098559 1119 24208315 SGTC_3060 1327-0027 12.5 µM 0.768146494294522 0.210975533139991 no 725 0.22120007857918 1036 16000455 YPR107C YTH1 SGTC_1212 0520-0165 585 µM 0.765365717036365 0.211811855692326 no 726 0.222026900737964 1086 5403258 SGTC_3254 9136651 49.47 µM 0.765201107965048 0.211861422831669 no 727 0.222075900013529 1112 16454030 SGTC_851 0394-0702 453 µM 0.765160256681424 0.211873725035002 no 728 0.222088061194269 1123 762646 SGTC_709 3807-1509 243 µM 0.762949891285334 0.212539990709276 no 729 0.222746640153998 1101 1886677 YPL242C IQG1 SGTC_2534 helenine 20.12 µM 0.762170640212973 0.212775170137145 no 730 0.222979083302266 1080 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_608 k048-0125 159 µM 0.76134069350231 0.213025816589277 no 731 0.223226800335934 1122 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_3089 9117425 49.47 µM 0.761170632344316 0.213077196837787 no 732 0.223277578402426 1061 9401657 SGTC_2056 5235370 200 µM 0.76059599789395 0.213250863508073 no 733 0.223449205459783 1041 5511916 SGTC_1915 st067105 30.6 µM 0.758401614404125 0.21391481152149 no 734 0.224105295856576 1122 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1334 1486-0610 236 µM 0.758325270538866 0.213937932298531 no 735 0.224128141297819 1086 3742339 SGTC_1277 0873-0036 22 µM 0.758137731178651 0.213994734861888 no 736 0.224184266935413 1137 5965735 SGTC_2024 5144227 134 µM 0.757238740785592 0.214267146027639 no 737 0.224453422109639 1108 3475211 SGTC_847 0342-0274 5.54 µM 0.757221329861542 0.21427242385884 no 738 0.224458636700503 1131 18097 SGTC_1494 4358-1428 177 µM 0.756695178457743 0.214431953550885 no 739 0.224616252050926 1149 1564571 SGTC_1674 st016616 23.6 µM 0.754571523507707 0.215076549646676 no 740 0.225253057646736 1123 625830 SGTC_2163 5671233 125 µM 0.754259201355662 0.215171444049966 no 741 0.225346797683925 1147 701023 SGTC_2161 5662504 8.5105 µM 0.753453404771142 0.215416385469887 no 742 0.225588750595368 1049 2859334 SGTC_1992 st073643 23.3 µM 0.752494293815548 0.215708141255861 no 743 0.225876930054711 1129 3161292 SGTC_2256 7954252 200 µM 0.752097080366767 0.215829038248001 no 744 0.225996339804494 1027 2972920 SGTC_3013 9080133 71.4286 µM 0.750704123187372 0.216253312774135 no 745 0.226415370523749 1166 17050193 SGTC_739 1486-1183 203 µM 0.750678193435289 0.216261215175322 no 746 0.226423174894252 1122 4346692 SGTC_955 1216-0110 33 µM 0.750394080686077 0.216347812875132 no 747 0.226508697469789 1067 3619719 SGTC_432 NS 1619 61.3 µM 0.748582894664142 0.216900334856454 no 748 0.227054322553884 1031 4552 A K+/calcium channel activator. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.748509044409385 0.216922880973592 no 749 0.227076585871878 1106 616764 SGTC_347 4534-1311 26.2 µM 0.748459244697509 0.216938085343793 no 750 0.22709159947114 1135 2862016 SGTC_1343 1487-0095 224 µM 0.746792842926656 0.217447210202646 no 751 0.227594308241823 1115 4560101 YGL055W OLE1 SGTC_1883 5-benzylidenerhodanine 20 µM 0.74652023635611 0.217530563511671 no 752 0.227676605936293 1123 1273210 SGTC_29 0299-0004 12.984 µM 0.74601736863177 0.217684370797793 no 753 0.227828461535088 1031 16871 A napthoquinone isolated from Swertia calycina. SGTC_548 1436-0017 110 µM 0.742252728044441 0.218837816467625 no 754 0.228967113542755 1182 9677137 SGTC_2680 butyl paraben 22.24 µM 0.741961889533236 0.218927072372062 no 755 0.229055213143858 1151 7184 An antifungal and steroid mimetic. SGTC_1979 st071809 45.3 µM 0.740029447937087 0.219520654100713 no 756 0.229641063073595 1132 4976333 SGTC_1351 1496-0003 46.5 µM 0.738654968678181 0.219943410391312 no 757 0.230058268278222 1149 3891978 SGTC_1507 4075-3230 155 µM 0.737327825545034 0.220352050207755 no 758 0.230461507372872 1061 659771 SGTC_1323 1348-1351 11.2 µM 0.736534727356471 0.220596460194244 no 759 0.230702670754244 1075 6989654 SGTC_3306 9127676 59.7925 µM 0.73470292670521 0.221161561556003 no 760 0.231260218753974 1134 41905287 SGTC_1072 oxiconazole 14.9 nM 0.734668012010204 0.221172340602521 no 761 0.231270853088772 1124 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_127 0180-0333 59.125 µM 0.733811310914931 0.221436919975712 no 762 0.231531872973186 1129 771601 SGTC_298 1391-0729 10 µM 0.733723684543833 0.221463992272561 no 763 0.231558580250554 1115 3237558 SGTC_2129 girgensonine 121.053 µM 0.730253918608608 0.22253750143938 no 764 0.232617495006986 1161 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3353 9151644 39.2805 µM 0.729557466630731 0.222753333362654 no 765 0.232830364472602 1135 4909158 SGTC_786 4544-0069 423 µM 0.729234948369827 0.222853322844696 no 766 0.232928978331509 1132 748821 YLR208W SEC13 SGTC_746 1095-0025 46.6 µM 0.728759053699001 0.223000909903795 no 767 0.233074531246671 1155 6749286 SGTC_1995 st072814 61.1 µM 0.728007015136072 0.223234249671269 no 768 0.233304646005621 1100 5769371 SGTC_3138 9097216 49.47 µM 0.72765448957654 0.223343677834034 no 769 0.233412557974444 1176 25237486 SGTC_111 0083-0039 52.457 µM 0.726487808223681 0.223706047319066 no 770 0.233769889416136 1072 759313 SGTC_2775 cyproheptadine 69.59 µM 0.722960757702602 0.224803574383217 no 771 0.234851996942377 1183 2913 A selective serotonin reuptake inhibitor. SGTC_1348 1493-0373 93.8 µM 0.722648904905271 0.224900761610752 no 772 0.234947807159115 1138 3010129 SGTC_2324 6149169 200 µM 0.722520026644664 0.224940932773773 no 773 0.234987408601994 1093 2888231 SGTC_1866 st057638 64 µM 0.721207536253664 0.225350265623422 no 774 0.235390917865864 1133 688802 SGTC_2847 9005661 71.43 µM 0.721165896120128 0.225363259036345 no 775 0.235403725876135 1060 2991449 SGTC_2412 st077135 33.4 µM 0.720382273859563 0.225607860102489 no 776 0.235644830486556 1176 13258915 SGTC_1304 1165-0502 251 µM 0.717979367071328 0.226358843019918 no 777 0.236385004468738 1155 767425 SGTC_165 k038-0023 64.381 µM 0.716055250447488 0.226961205726737 no 778 0.23697861695474 1185 46368543 SGTC_1210 3013-0140 750 nM 0.715729124947309 0.227063391885618 no 779 0.237079311630858 1183 905973 SGTC_1708 st033234 31.827 µM 0.712968775784333 0.22792934094643 no 780 0.237932539422011 1216 674664 SGTC_734 2023-0417 80 µM 0.711782942170094 0.228301918529676 no 781 0.238299598581981 1134 3935732 SGTC_1265 0819-1001 68.8 µM 0.711338367624002 0.228441687773662 no 782 0.238437290667603 1176 3106768 SGTC_376 3970-0862 59.1 µM 0.71093653828647 0.22856805975916 no 783 0.238561781327222 1157 3135186 SGTC_3245 9134821 49.47 µM 0.70978590744098 0.228930140705013 no 784 0.238918454734757 1152 17014901 SGTC_430 0958-0115 16.4 µM 0.708372086229936 0.229375482893983 no 785 0.239357111087077 1105 6833180 SGTC_3144 9087057 49.47 µM 0.707326391754984 0.2297051803178 no 786 0.239681834143344 1119 17249618 SGTC_3058 9093861 49.47 µM 0.707103560765889 0.22977547107754 no 787 0.239751061668238 1187 17217477 SGTC_1479 0549-0158 134 µM 0.70699535661675 0.22980960780073 no 788 0.239784681687827 1235 5440202 SGTC_1448 4255-0083 152 µM 0.706887270628589 0.229843710080769 no 789 0.239818267561532 1216 5399660 SGTC_1875 nocodazole 6 µM 0.705998727144721 0.230124162366043 no 790 0.240094464507098 1185 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2623 humulene 100 µM 0.704712111420658 0.23053059788856 no 791 0.240494706312789 1113 6187145 An anti-inflammatory. SGTC_680 0417-1641 114 µM 0.704402697951884 0.230628399874839 no 792 0.240591013154843 1159 2835990 SGTC_1969 st069479 40.1 µM 0.703819703135169 0.230812740711325 no 793 0.240772530908259 1154 3895485 SGTC_904 1141-0088 396 µM 0.703634610673682 0.230871283478614 no 794 0.240830175763556 1151 1378119 SGTC_2644 guaiazulene 100 µM 0.703520966499894 0.230907232024055 no 795 0.240865572615877 1201 3515 A coloring agent. SGTC_1174 0739-0097 51.1 µM 0.702601461998074 0.231198209625518 no 796 0.241152075571802 1187 728447 SGTC_375 3970-0961 9.27 µM 0.700977424978423 0.231712636258021 no 797 0.241658551863929 1151 2898222 SGTC_3201 9113999 49.47 µM 0.69941809617293 0.232207165642665 no 798 0.242145390983216 1161 16649224 SGTC_3208 9114115 49.47 µM 0.697638426760929 0.232772291384335 no 799 0.242701671912771 1164 650895 SGTC_1399 3562-5772 25 µM 0.697368356597872 0.23285811764851 no 800 0.242786149627026 1137 23847490 SGTC_1376 2910-0861 41.3 µM 0.697055952657794 0.232957419195252 no 801 0.242883889158731 1194 1112859 SGTC_2038 4100038 30.985 µM 0.696520253811412 0.233127752587179 no 802 0.243051538874855 1174 3596803 SGTC_1179 1021-1431 9.29 µM 0.696448364625444 0.233150616080804 no 803 0.243074041728274 1184 2840958 SGTC_3122 9126309 49.47 µM 0.69592981787792 0.233315570523576 no 804 0.243236391325623 1247 17591206 SGTC_211 3455-0679 143.504 µM 0.695679158365842 0.233395330809799 no 805 0.243314890257279 1217 748649 SGTC_1999 st074831 12.5 µM 0.695529116163228 0.233443081732504 no 806 0.243361885459388 1182 17112523 SGTC_1396 3511-0007 98.6 µM 0.695348040434573 0.233500716289141 no 807 0.243418607303379 1154 X1396 SGTC_3266 9136860 49.47 µM 0.695290556136541 0.233519014604899 no 808 0.243436615712754 1144 4871271 YPR165W RHO1 SGTC_2736 butenafine 14.65 µM 0.695163142673509 0.233559575502673 no 809 0.243476533766373 1189 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_121 0557-0495 61.343 µM 0.692543058577828 0.234394520726564 no 810 0.244298177551472 1326 3104427 SGTC_976 1348-1067 47.6 µM 0.692261081196502 0.234484477123812 no 811 0.244386693081002 1248 5310671 YGL099W LSG1 SGTC_464 bw-b 70c 158 µM 0.692008866994926 0.234564954653731 no 812 0.244465880290294 1219 5353454 SGTC_294 k038-0071 157 µM 0.69172609839536 0.234655199767802 no 813 0.244554677040455 1202 24152826 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.691273682256095 0.234799627529217 no 814 0.244696783690388 1200 688798 SGTC_2073 5212005 126 µM 0.690687319423606 0.234986889062207 no 815 0.244881029944257 1086 691789 SGTC_887 0885-0007 9.62 µM 0.689787706870935 0.23527435074634 no 816 0.245163850243363 1214 5719458 SGTC_1165 k072-0275 30.3 µM 0.687514071174102 0.236001731661696 no 817 0.245879418354245 1228 6153523 YGL055W OLE1 SGTC_1018 4259-0013 28.1 µM 0.686495730506316 0.236327920303888 no 818 0.246200277863807 1197 6801262 SGTC_95 0471-0001 561.058 µM 0.684245285284264 0.237049648738398 no 819 0.24691014536916 1155 4015405 SGTC_2312 7706453 155.7 µM 0.68390055994629 0.237160310668552 no 820 0.247018980215345 1232 976098 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.681886304655339 0.237807483463785 no 821 0.247655422972418 1239 1273210 SGTC_1604 st002052 72.4 µM 0.681686807129363 0.237871633957229 no 822 0.247718505690281 1245 6254834 YHR062C RPP1 SGTC_1127 asiatic acid 681.4 nM 0.680905793137534 0.238122868357567 no 823 0.247965551107188 1207 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2068 5226020 147 µM 0.679439260786339 0.23859501100511 no 824 0.248429790352267 1249 1810509 SGTC_3041 9091929 49.47 µM 0.678937286837881 0.23875673659475 no 825 0.248588799435579 1281 25236887 SGTC_417 st075190 100 µM 0.678537094344555 0.238885713264039 no 826 0.248715606282827 1231 222757 SGTC_1554 st069299 38.7 µM 0.678260214893327 0.238974970091285 no 827 0.248803359744876 1216 24207999 SGTC_685 1278-0033 54.9 µM 0.677100776058775 0.239348933008599 no 828 0.249171008279654 1270 3590572 SGTC_1920 st075728 45.7 µM 0.675749464862745 0.23978518509482 no 829 0.249599862312012 1239 3400306 SGTC_1317 1273-0028 910 nM 0.672038664822606 0.240985393659921 no 830 0.250779540932546 1217 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_939 1165-0479 45.3 µM 0.669716772541861 0.241738037124408 no 831 0.251519178769601 1194 1377347 SGTC_3305 9127027 53.8275 µM 0.668506199639157 0.242130950830677 no 832 0.251905262916366 1178 41905295 SGTC_2983 9022671 12.99 µM 0.667831769600501 0.242349999602546 no 833 0.2521204923317 1245 6405161 SGTC_2447 5741742 33.78 µM 0.667421869123511 0.242483184012483 no 834 0.252251350371391 1275 1776504 SGTC_1720 st037298 9.481 µM 0.66536549819264 0.243151935728114 no 835 0.252908373434928 1238 597396 SGTC_1515 3460-0031 42.1 µM 0.663037539370948 0.243910212343861 no 836 0.25365325604251 1212 2876596 SGTC_526 4469-0568 170 µM 0.662976776247819 0.243930021542758 no 837 0.253672713984174 1244 2901964 SGTC_2179 6298986 200 µM 0.66268046320513 0.244026634083063 no 838 0.253767612403315 1214 738374 SGTC_2001 4023502 57.655 µM 0.660753013293677 0.244655580501371 no 839 0.254385360014416 1258 108941 YCR052W RSC6 SGTC_1634 st006576 41 µM 0.66008099479309 0.244875071995477 no 840 0.254600927068578 1249 3915356 SGTC_2194 5927483 104.545 µM 0.659971988786077 0.24491068500672 no 841 0.254635902539063 1264 760979 SGTC_662 k832-1615 104 µM 0.657959900416592 0.24556854834416 no 842 0.255281949221339 1253 5878478 SGTC_1128 3448-9350 235 µM 0.656961974976249 0.24589517733691 no 843 0.255602683364457 1242 619386 SGTC_3021 9087658 49.47 µM 0.656923913504635 0.245907639775878 no 844 0.25561492052144 1247 25237042 SGTC_25 0118-0223 35.662 µM 0.655715432600178 0.24630350794777 no 845 0.256003618669939 1298 5333628 SGTC_792 4534-1957 155 µM 0.65487515241911 0.246578963981356 no 846 0.256274069653462 1263 1717904 SGTC_230 MPP+ 141.667 µM 0.65473153997999 0.246626058728766 no 847 0.256320307378838 1224 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_3310 9130229 44.1445 µM 0.653801939389164 0.246931018620057 no 848 0.256619708430499 1281 7761258 SGTC_2524 avocatin b 10.57 µM 0.653347521613733 0.247080165932914 no 849 0.256766131253296 1200 6710748 SGTC_3182 9108849 49.47 µM 0.651655834747912 0.247635828479189 no 850 0.257311609885712 1271 17133045 SGTC_2844 9010103 25.97 µM 0.651205088110814 0.247783996205999 no 851 0.257457053145034 1258 2480525 SGTC_1452 4194-0072 190 µM 0.650792561605476 0.247919641826925 no 852 0.257590201264242 1318 1343545 SGTC_3012 9080433 71.4286 µM 0.650758240869488 0.247930928844947 no 853 0.257601280324624 1274 17688859 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.649586299182583 0.248316508369692 no 854 0.257979742697623 1246 75037 A free radical scavenger. SGTC_589 1227-0070 34.1 µM 0.649348588377876 0.248394756376228 no 855 0.258056543286956 1270 2841384 SGTC_2792 7535235 81.82 µM 0.647990179596306 0.248842160052583 no 856 0.258495650988842 1232 1281891 SGTC_3289 9119912 71.43 µM 0.647910141697577 0.248868534602747 no 857 0.258521535428892 1286 17014829 SGTC_2199 6590217 200 µM 0.647164837116638 0.249114203093417 no 858 0.258762633074895 1238 703109 SGTC_186 3455-3465 67.277 µM 0.646163177692165 0.249444574758796 no 859 0.25908684182584 1214 755278 SGTC_910 3454-3003 490 µM 0.646036915180703 0.249486235728458 no 860 0.259127724321618 1236 820824 SGTC_3183 9108214 49.47 µM 0.645419223731875 0.249690099499098 no 861 0.259327774483943 1200 4974831 SGTC_2739 tacrine 100.86 µM 0.644094568642075 0.250127588692926 no 862 0.259757056074324 1278 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_671 0560-0003 407 µM 0.643887212427389 0.250196108290232 no 863 0.259824287278688 1213 3238678 SGTC_2428 5615643 7.78 µM 0.643272443742045 0.250399313348269 no 864 0.260023666777064 1289 2253075 SGTC_1146 3579-1023 7 µM 0.642986116280936 0.250493985606233 no 865 0.260116554357938 1334 X1146 SGTC_973 1325-0077 65.9 µM 0.642948598135188 0.250506392135276 no 866 0.260128726898704 1310 2835149 SGTC_2841 9004761 38.96 µM 0.642620785604541 0.250614807282429 no 867 0.260235096227929 1183 2991039 SGTC_1360 1598-0022 39.8 µM 0.642529962624357 0.25064484892833 no 868 0.260264570632652 1318 761525 SGTC_3302 9125395 16.351 µM 0.641974840560107 0.250828508891263 no 869 0.26044475947241 1262 17599668 SGTC_1246 0422-0085 105 µM 0.640141944990742 0.25143542083363 no 870 0.26104016082872 1270 264295 SGTC_297 0986-0032 24 µM 0.639300549367342 0.251714285077258 no 871 0.261313715577969 1245 2847425 SGTC_2827 7993847 71.43 µM 0.637564054916951 0.252290328433664 no 872 0.261878750289996 1264 2985692 SGTC_2434 5670830 169.91 µM 0.637517156907883 0.252305895436866 no 873 0.26189401903118 1279 1549830 SGTC_669 0108-0021 26.2 µM 0.637484381045205 0.252316775132354 no 874 0.261904690249088 1415 17201 SGTC_2703 st077852 53.4 µM 0.636981528741915 0.252483724087293 no 875 0.262068437655632 1281 6281836 SGTC_934 2950-0684 338 µM 0.634888011561683 0.253179405229057 no 876 0.26275072823324 1300 1121253 SGTC_2221 6807166 181.081 µM 0.634090377250298 0.253444726127334 no 877 0.263010921169421 1251 674925 SGTC_151 3013-0144 2.285 µM 0.63136754858062 0.254351533162272 no 878 0.263900114678474 1306 906558 YHR107C CDC12 SGTC_2532 xanthone 78.9 µM 0.6307777131974 0.254548194975375 no 879 0.264092938824261 1256 7020 An insecticide. SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.629420804446729 0.255000915191339 no 880 0.264536800643783 1331 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.628632808076168 0.255264016209508 no 881 0.264794738212423 1312 229346 A bile salt which induces apoptosis. SGTC_990 3985-0011 41.3 µM 0.627557205799287 0.255623373772492 no 882 0.265147025080554 1289 5399565 YGL099W LSG1 SGTC_2307 7538926 6.34 µM 0.627377539291266 0.255683425901867 no 883 0.265205893584709 1319 96582 SGTC_38 0929-0051 58.268 µM 0.627058072000203 0.255790223545041 no 884 0.265310584806157 1310 1379719 SGTC_2191 5911152 200 µM 0.626909670509161 0.255839841956918 no 885 0.265359223941312 1296 2875902 SGTC_2248 tofa 1.1 µM 0.625973484980997 0.256152973714341 no 886 0.265666166489349 1299 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3342 9147791 14.508 µM 0.624762777854626 0.256558222563544 no 887 0.266063381868194 1263 1838168 SGTC_3149 9097855 49.47 µM 0.622136720517269 0.257438364898024 no 888 0.26692598557838 1335 25236625 YMR079W SEC14 SGTC_752 1896-0090 130 µM 0.622020504586981 0.257477351733335 no 889 0.266964192645249 1302 772567 SGTC_2109 5483026 200 µM 0.62020487310493 0.258086837737884 no 890 0.267561456812356 1347 759335 SGTC_397 arbidol 50 µM 0.620052939449761 0.258137873969719 no 891 0.26761146693723 1380 131410 A RNA synthesis inhibitor. SGTC_2220 6782180 200 µM 0.619638120192749 0.25827724308842 no 892 0.267748031859428 1258 833803 SGTC_1073 triclabendazole 3.09 µM 0.619495628312034 0.258325125870476 no 893 0.267794950494418 1345 50248 An antihelmetic and likely tubulin inhibitor. SGTC_3320 9137005 35.139 µM 0.619351445356065 0.258373581601216 no 894 0.267842430169572 1303 4908713 SGTC_1690 st023502 41.2 µM 0.617278019003058 0.259070920820615 no 895 0.268525681357184 1311 24207482 SGTC_2985 9022375 71.43 µM 0.616344246451083 0.259385286749786 no 896 0.268833671058695 1337 4939335 SGTC_2601 securinine 100 µM 0.614357943083639 0.260054654883234 no 897 0.2694894104664 1287 442872 A GABA receptor antagonist. SGTC_2386 9075165 157.42 µM 0.613372457426136 0.260387085809553 no 898 0.269815046655065 1289 16452277 SGTC_2917 7979103 53.79 µM 0.612427908192392 0.260705913091307 no 899 0.2701273409321 1359 2980565 SGTC_179 1273-0063 6.77 µM 0.611822326789865 0.260910429327301 no 900 0.270327658083986 1284 3108139 SGTC_2065 5221596 34.26 µM 0.611432403422087 0.26104215744203 no 901 0.270456678115182 1333 788581 SGTC_2515 chrysin 20.77 µM 0.611403047515832 0.261052076154482 no 902 0.270466392807491 1342 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.611283458540169 0.261092484630694 no 903 0.270505969953887 1365 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2167 5876490 200 µM 0.610404949742356 0.261389426593551 no 904 0.270796795051671 1470 686534 SGTC_3142 9086498 49.47 µM 0.60870083841484 0.261965921967615 no 905 0.271361375600349 1265 25236367 SGTC_459 nigericin 15.3 µM 0.60746264996978 0.262385205657454 no 906 0.271771961179155 1373 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_180 1486-1293 102.781 µM 0.606108120472282 0.262844278802126 no 907 0.272221479497291 1405 4140536 SGTC_1114 scopoletin 1.73284 µM 0.605106329637478 0.263184066824799 no 908 0.272554174411653 1363 5280460 A coumarin with genotoxic properties. SGTC_3327 9140648 26.9345 µM 0.603860145829809 0.263607061170319 no 909 0.272968313814932 1336 8029710 SGTC_3015 9080845 49.47 µM 0.603707619208368 0.263658857362994 no 910 0.273019023814709 1400 5296973 SGTC_2288 7946289 167.31 µM 0.6025084358475 0.264066266295678 no 911 0.273417874790848 1403 1246052 SGTC_964 1287-0107 19.4 µM 0.601720123949069 0.264334260939266 no 912 0.273680226097056 1398 51516812 YPR165W RHO1 SGTC_3251 9135047 49.47 µM 0.601443293976034 0.264428404942459 no 913 0.273772385036623 1391 17682963 SGTC_2160 5660466 132.927 µM 0.600585712134756 0.264720158620122 no 914 0.27405797835838 1296 2859134 SGTC_1469 k284-2957 126 µM 0.600528135513714 0.264739752340014 no 915 0.274077157892091 1364 23884841 SGTC_2799 7812892 81.82 µM 0.599703328018633 0.265020520925847 no 916 0.274351984950881 1361 20205235 SGTC_2223 6903751 107.57 µM 0.599511501837107 0.26508584119171 no 917 0.274415921207534 1319 5598863 SGTC_2640 pentamidine 10.38 µM 0.598832801918243 0.265317016359232 no 918 0.2746421930015 1360 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1618 st003135 44.5 µM 0.594854145956814 0.266674260208001 no 919 0.275970485179113 1303 1270615 SGTC_2462 5162487 171.77 µM 0.594512295788826 0.266791039513253 no 920 0.276084760420074 1324 2259986 SGTC_950 1165-0508 94.1 µM 0.594442902287602 0.266814748155733 no 921 0.276107960434016 1315 6148369 SGTC_276 colchicine 750 µM 0.594407767725059 0.26682675246361 no 922 0.276119707177608 1374 2833 A microtubule depolymerizer. SGTC_363 0455-0021 3.06 µM 0.592306511589412 0.267545177438117 no 923 0.276822678153384 1372 4597466 SGTC_1785 bathophenanthroline 24 µM 0.589924387380746 0.268360809795041 no 924 0.277620671666839 1325 72812 An iron chelator. SGTC_2075 5212009 200 µM 0.589560919504819 0.268485370006564 no 925 0.277742529392766 1345 780898 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.588819998600675 0.268739373116284 no 926 0.277991014429879 1376 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2518 prenyletin 46.28 µM 0.588650212245538 0.268797596409784 no 927 0.278047971502149 1296 3873459 A coumarin with calcium channel inhibitory activity. SGTC_3114 9122766 49.47 µM 0.588175976059336 0.268960255475705 no 928 0.278207090439575 1294 17176985 SGTC_3235 9132602 49.47 µM 0.584894119722714 0.270087257363908 no 929 0.279309456363286 1388 4912240 SGTC_193 1273-0060 1.558 µM 0.584251827559184 0.270308099032262 no 930 0.279525448490358 1259 2847393 YHR072W ERG7 SGTC_985 1493-0307 8.71 µM 0.583357596943324 0.270615715884541 no 931 0.279826298301913 1341 3278274 SGTC_2813 7971799 71.43 µM 0.582346651177347 0.270963693389031 no 932 0.28016660413183 1411 2234054 SGTC_2941 9056145 11.23 µM 0.581902824121842 0.271116533527426 no 933 0.28031606906853 1272 2119517 SGTC_3069 9117009 49.47 µM 0.581639092108469 0.271207374932858 no 934 0.280404902781433 1279 41904981 SGTC_886 0866-0150 153 µM 0.580619257281284 0.271558795568946 no 935 0.280748545269573 1424 271463 SGTC_1141 3253-0389 52.6 µM 0.578790855584227 0.272189404093107 no 936 0.281365151039283 1342 5402031 SGTC_50 0929-0078 56.389 µM 0.578192862230351 0.272395807474914 no 937 0.281566958621762 1389 1377751 SGTC_2341 7987486 176.74 µM 0.575982690389016 0.273159344383515 no 938 0.282313440788859 1411 1258686 SGTC_2158 5657123 3.6195 µM 0.575236837882168 0.273417249404927 no 939 0.282565566046883 1356 2858827 SGTC_3091 9116372 49.47 µM 0.575079517724783 0.273471663835344 no 940 0.282618759799068 1370 17169793 SGTC_440 fluspirilene 35.1 µM 0.575059093283915 0.273478728703483 no 941 0.282625666149766 1447 3396 An atypical antipsychotic. SGTC_602 3130-1533 38.1 µM 0.573583765495587 0.273989287325803 no 942 0.283124750104395 1432 720941 SGTC_813 k007-0158 173 µM 0.572700295437823 0.274295250327725 no 943 0.283423818696502 1419 6523916 SGTC_584 0986-0246 15.4 µM 0.570339532386326 0.275113655617481 no 944 0.284223716502572 1457 53315 YDR232W HEM1 SGTC_1216 1165-0504 9.65 µM 0.569823878911477 0.275292577001239 no 945 0.284398578987266 1406 6304004 SGTC_2246 7293507 91.5585 µM 0.56935595128626 0.275454988026638 no 946 0.284557301704321 1428 887656 SGTC_261 5-fluorouridine 15.376 µM 0.569195811668258 0.275510581035054 no 947 0.284611631347816 1426 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1709 st033179 39.1045 µM 0.567809650329208 0.275992022113692 no 948 0.2850821131658 1368 573381 SGTC_2967 9089538 49.85 µM 0.567744543703033 0.276014645079297 no 949 0.285104220344401 1446 728216 SGTC_2208 7283366 200 µM 0.567522249481088 0.276091893764685 no 950 0.285179707269021 1433 898663 SGTC_3173 9105693 49.47 µM 0.566236131006956 0.27653903652346 no 951 0.285616635713241 1425 17096658 SGTC_874 0599-0792 117 µM 0.565416732386025 0.276824100561054 no 952 0.285895173116936 1412 765305 SGTC_1135 dihydrocapsaicin 536.708 nM 0.564584570942872 0.277113751940776 no 953 0.286178181082244 1326 107982 A Capsaicinoid. SGTC_2143 5623677 140.463 µM 0.562971088189901 0.277675780911828 no 954 0.286727285705791 1372 5375313 SGTC_1970 st070122 35.8 µM 0.562647839071856 0.277788446095207 no 955 0.286837354712949 1442 102928 SGTC_940 3232-1287 54.8 µM 0.562159420549164 0.277958721721481 no 956 0.287003703249556 1365 1585493 YIL048W NEO1 SGTC_1251 0490-5699 265 µM 0.561838584890143 0.278070601237487 no 957 0.287113000260844 1435 3883818 SGTC_2086 5274770 176.623 µM 0.560288212361645 0.278611545417738 no 958 0.287641433170032 1395 689278 SGTC_1485 3909-9022 254 µM 0.560056592547715 0.278692404418274 no 959 0.287720418504804 1388 714516 SGTC_487 nimodipine 119 µM 0.558357821949629 0.279285798014099 no 960 0.288300034104494 1326 4497 L-type voltage-gated calcium channels inhibitor SGTC_331 k048-0133 24.5 µM 0.557864590196717 0.279458202583042 no 961 0.288468426433959 1379 6813582 SGTC_773 4358-1457 44.6 µM 0.557299501686649 0.279655787520888 no 962 0.288661408056141 1477 1186886 SGTC_1631 benzylvanillin 81.9 µM 0.557246484797383 0.279674328517935 no 963 0.288679516808921 1437 75506 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.557019209708035 0.279753817624068 no 964 0.28875715225418 1452 688751 SGTC_2749 bexarotene 57.39 µM 0.556627884842256 0.279890708562401 no 965 0.288890848887746 1376 82146 An retinoic acid receptor inhibitor. SGTC_2184 6075246 200 µM 0.55539028161349 0.280323853273141 no 966 0.289313869235166 1423 2267320 SGTC_2986 9022445 71.43 µM 0.554536352475717 0.280622906287808 no 967 0.289605917043967 1434 6459286 SGTC_537 1334-0398 209 µM 0.553753655290751 0.280897148792843 no 968 0.289873724691754 1451 5846986 SGTC_59 0330-0160 1.33 µM 0.551632353376783 0.281641064128813 no 969 0.290600132696948 1397 4293482 SGTC_1724 st037281 8.293 µM 0.551177262757146 0.281800782673595 no 970 0.290756082533156 1397 574124 YDL195W SEC31 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.550626658375354 0.28199408105442 no 971 0.290944815194562 1457 688801 SGTC_933 2914-0560 114 µM 0.549926610059883 0.282239936268793 no 972 0.291184855925273 1511 463887 SGTC_520 3584-0023 682 µM 0.548543217049881 0.282726083551584 no 973 0.291659481571148 1380 1340790 SGTC_1075 aripiprazole 15.2 µM 0.547910512786931 0.282948560347159 no 974 0.29187667497558 1411 60795 An atypical antipschotic. YIL048W NEO1 SGTC_153 4077-0274 519.67 µM 0.545712737710089 0.283722012919662 no 975 0.292631707364726 1518 3121976 SGTC_1159 4092-0538 61.2 µM 0.545691816447411 0.283729380503054 no 976 0.292638899096302 1462 717301 SGTC_1891 st059073 26.2 µM 0.545606170338157 0.283759542393669 no 977 0.292668340996962 1509 688754 SGTC_2772 vinpocetine 57.06 µM 0.545282143290072 0.283873668512323 no 978 0.292779741717296 1451 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2976 9009005 19.48 µM 0.54266559630608 0.284796051091881 no 979 0.293680032914007 1538 2993148 SGTC_1603 st002045 67.8 µM 0.542547401499469 0.284837750747656 no 980 0.293720731149062 1409 5887985 SGTC_535 2293-4129 48.2 µM 0.541970933153786 0.285041173096587 no 981 0.293919264953526 1494 396118 YIL048W NEO1 SGTC_2192 5915882 198.485 µM 0.54151522952974 0.285202029373344 no 982 0.294076251691226 1393 2876149 SGTC_340 k038-0059 454 µM 0.540844544684915 0.285438849322641 no 983 0.294307368434554 1453 23733424 SGTC_1704 st028805 70.8 µM 0.539448935478028 0.285931941206741 no 984 0.294788561448148 1414 2876101 SGTC_1524 corynanthine 62.1 µM 0.537724035207619 0.286541936011932 no 985 0.295383791630142 1485 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_390 dec-rvkr-cmk 16.7 µM 0.537604780228001 0.286584132223228 no 986 0.295424964677231 1476 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1917 st066507 28.5 µM 0.536306250480543 0.287043784082422 no 987 0.295873455735349 1437 3156428 SGTC_2717 st081029 62.2815 µM 0.535970230151751 0.287162784957394 no 988 0.295989562600413 1406 5292846 SGTC_1833 st055984 71 µM 0.535928511013612 0.287177561329906 no 989 0.296003979492411 1418 676288 SGTC_2908 7930301 100 µM 0.533415915653874 0.288068152601108 no 990 0.296872851299686 1347 2223178 SGTC_411 enrofloxacin 100 µM 0.530460450011891 0.28911738484974 no 991 0.297896361719619 1582 71188 A bacterial gyrase inhibitor. SGTC_1291 0993-0025 5.79 µM 0.528551042705395 0.289796205714456 no 992 0.29855846486459 1530 4353356 SGTC_2868 9035608 32.47 µM 0.528127639697171 0.289946832602754 no 993 0.298705374062595 1402 6462614 SGTC_2981 9013952 38.96 µM 0.527642165501884 0.290119586667269 no 994 0.298873860685951 1336 2996344 SGTC_1886 st057356 49.9 µM 0.527106131053993 0.290310388411023 no 995 0.299059944677542 1378 24207747 SGTC_124 0136-0217 7.121 µM 0.526006416624473 0.290702016188502 no 996 0.299441874351156 1554 3976905 SGTC_3055 9094636 49.47 µM 0.525923413331396 0.290731585156285 no 997 0.299470710281857 1490 25236176 SGTC_1190 1486-1332 13 µM 0.523958878105854 0.291431838450223 no 998 0.300153570866678 1411 4150046 SGTC_33 0986-0033 35.816 µM 0.523769617914595 0.291499341267247 no 999 0.300219393735746 1441 2848082 SGTC_883 0850-0245 24.6 µM 0.521339646842619 0.292366678302952 no 1000 0.301065093364463 1541 6823229 YPR165W RHO1 SGTC_593 1203-0218 61.7 µM 0.519959752278171 0.292859741910505 no 1001 0.301545813723451 1529 3666956 SGTC_857 0438-0306 1.35 µM 0.517278884915622 0.293818770584305 no 1002 0.302480745829643 1472 4686136 SGTC_580 1123-0028 41 µM 0.516316406926984 0.294163432644369 no 1003 0.302816719478896 1483 1677248 YPR107C YTH1 SGTC_3270 9137563 49.47 µM 0.515841598215395 0.294333529782138 no 1004 0.302982523202679 1499 17015724 SGTC_1346 1488-2224 62.4 µM 0.515276954230383 0.294535868925825 no 1005 0.303179750368602 1492 3722427 SGTC_2468 5987765 72.9 µM 0.514550267416758 0.294796370241917 no 1006 0.303433662693337 1513 26772094 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.513434618558087 0.295196512522327 no 1007 0.303823667382901 1444 16486 A toxic proline analog. SGTC_935 2996-0153 430 µM 0.513146910358588 0.295299743430861 no 1008 0.303924279684263 1485 23738523 SGTC_2436 5633522 8.09 µM 0.513007335570343 0.295349829434293 no 1009 0.303973094700398 1537 5724242 SGTC_2994 9053520 71.4286 µM 0.512816700250473 0.29541824467435 no 1010 0.30403977332158 1541 4647384 SGTC_2171 5739187 198.077 µM 0.509019572569061 0.296782474631175 no 1011 0.305369252485426 1401 2262761 SGTC_585 0kpi-0023 191 µM 0.508488821683812 0.296973392022229 no 1012 0.305555288226218 1520 64601 SGTC_410 α-linolenic acid 100 µM 0.50845420845877 0.296985844761241 no 1013 0.305567422398912 1505 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3309 9129340 25.759 µM 0.507304341579741 0.297399666041186 no 1014 0.305970646384966 1539 17158987 SGTC_1248 0469-0687 58.6 µM 0.505939984732315 0.297891020672413 no 1015 0.306449390775524 1536 4017482 SGTC_982 1491-0518 27.5 µM 0.503355742556932 0.298822713499241 no 1016 0.307357090939235 1467 3091256 SGTC_1570 verbenone 133 µM 0.502652512584887 0.299076476919521 no 1017 0.307604301103682 1550 29025 A natural terpanoid with antifungal properties. SGTC_2806 7952793 58.44 µM 0.501802641580441 0.299383286852754 no 1018 0.307903177397041 1512 2972490 SGTC_112 phenothiazine 287.218 µM 0.500266589474739 0.299938175208888 no 1019 0.308443688071601 1546 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1649 st011737 51.3 µM 0.498936288691843 0.300419113062003 no 1020 0.308912134131156 1454 1761035 SGTC_174 3553-0389 74.3 µM 0.497733551864352 0.300854232910688 no 1021 0.309335928137733 1496 738071 SGTC_1180 1193-0155 285 µM 0.497654825615747 0.300882723991552 no 1022 0.309363676819663 1464 2921347 SGTC_1235 benzylparaben 21.5 µM 0.496953385178302 0.301136629447814 no 1023 0.309610961877935 1461 7180 SGTC_606 k015-0008 38.6 µM 0.496039607099224 0.301467541015263 no 1024 0.309933233518881 1602 1970475 SGTC_745 0469-0705 296 µM 0.495694806879118 0.30159244795869 no 1025 0.310054875785532 1600 3486736 SGTC_2564 betulinic acid 100 µM 0.49496280948709 0.301857697657406 no 1026 0.310313186475986 1682 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1579 chlormadinone acetate 49.4 µM 0.492929702808815 0.302594972214683 no 1027 0.311031129469865 1574 45114258 A steroidal progestin. SGTC_1194 1488-0194 225 µM 0.491959267472745 0.302947169817816 no 1028 0.311374069441654 1498 1391452 SGTC_2738 aclarubicin 5.55 µM 0.491424490579511 0.303141333399753 no 1029 0.311563123055076 1513 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_780 0109-0199 192 µM 0.488178146505497 0.304321188899271 no 1030 0.312711831167107 1627 610414 SGTC_1279 0874-0590 65.2 µM 0.488150285707435 0.304331323508543 no 1031 0.31272169751663 1520 3523074 SGTC_2540 epiandrosterone 100 µM 0.488088109731349 0.304353941106201 no 1032 0.312743716390299 1523 441302 A steroid. SGTC_1495 4469-0029 237 µM 0.487099287688886 0.304713742943184 no 1033 0.313093985592092 1474 793680 SGTC_3095 9117207 49.47 µM 0.486998625930674 0.304750381255501 no 1034 0.31312965234955 1528 17015229 SGTC_747 3448-8087 38.7 µM 0.484035896372216 0.305829615008394 no 1035 0.314180196925391 1488 5168703 SGTC_1098 clofazimine 15.1 µM 0.482297845874992 0.306463521268929 no 1036 0.314797188653897 1553 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2950 9072895 21.46 µM 0.482146882310347 0.306518608472608 no 1037 0.314850803755559 1442 17332245 SGTC_106 0092-0003 11.579 µM 0.481747535023851 0.306664352959678 no 1038 0.314992651794497 1584 1072148 SGTC_807 1315-0151 48 µM 0.478934045337784 0.307692020481289 no 1039 0.315992774971811 1631 4011080 SGTC_160 3453-0671 289.699 µM 0.47665507773251 0.308525554187712 no 1040 0.316803878169091 1441 5322268 SGTC_1048 3161-0300 24.5 µM 0.476401915974534 0.308618209280704 no 1041 0.31689403497161 1480 2165101 SGTC_3240 9133527 49.47 µM 0.475886066025198 0.308807043772579 no 1042 0.317077774810034 1491 17617455 SGTC_1899 st063254 59.6 µM 0.47523281020804 0.309046250259219 no 1043 0.317310521774202 1436 3093813 SGTC_2316 5844804 197.44 µM 0.474905913035607 0.309165982512984 no 1044 0.317427018326461 1592 776813 SGTC_2629 bisabolol 100 µM 0.474724792627419 0.309232330006216 no 1045 0.317491572108396 1593 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.473167104461563 0.309803194389835 no 1046 0.318046982377045 1576 6708739 YPR165W RHO1 SGTC_2650 prasterone 100 µM 0.470951690588648 0.310615893717311 no 1047 0.318837616875395 1515 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_2808 7946468 45.46 µM 0.470039666750362 0.310950728317047 no 1048 0.319163338946848 1568 2970879 SGTC_1264 0783-0040 158 µM 0.469990377708075 0.31096882844276 no 1049 0.319180946116691 1455 2855798 SGTC_3272 9137413 49.47 µM 0.469841817508251 0.311023386099244 no 1050 0.319234017674953 1436 17614870 SGTC_3200 9114385 49.47 µM 0.467977213985566 0.311708501116564 no 1051 0.319900442276934 1481 17018030 YLR208W SEC13 SGTC_770 0389-1121 67.2 µM 0.467881236420921 0.311743784016021 no 1052 0.319934761205292 1632 6753108 SGTC_2616 abietic acid 100 µM 0.46785249509119 0.31175435012825 no 1053 0.31994503861148 1569 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2188 6126565 140.678 µM 0.467478261081627 0.311891943101798 no 1054 0.320078870882229 1558 874518 SGTC_377 3970-0964 33.1 µM 0.465869967860317 0.312483555893026 no 1055 0.320654289497578 1575 16481235 SGTC_2881 9058953 51.95 µM 0.464677485543341 0.312922524431076 no 1056 0.321081216905587 1451 17122249 SGTC_599 1935-0052 86.5 µM 0.463499771278527 0.313356317140445 no 1057 0.321503089377518 1508 9557311 SGTC_66 0109-0187 42.4 µM 0.462820687856822 0.313606564414777 no 1058 0.321746450570893 1478 759417 SGTC_3028 9087778 49.47 µM 0.457669428720551 0.315507628918103 no 1059 0.323594977404639 1472 17217395 SGTC_1609 st001574 46.4 µM 0.456834613518263 0.315816178307701 no 1060 0.323894962299868 1520 3960012 SGTC_917 harmaline 728.087 nM 0.456712871541123 0.315861185120784 no 1061 0.323938718976241 1587 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_541 4513-1321 94 µM 0.456578508366031 0.315910861036007 no 1062 0.323987014806111 1494 747515 SGTC_1587 estradiol valerate 56.1 µM 0.455395585460496 0.316348347314393 no 1063 0.324412335313773 1609 13791 A steroid. SGTC_3120 9124077 49.47 µM 0.454901846867289 0.316531025225586 no 1064 0.324589927084842 1556 18774327 YGL155W CDC43 SGTC_500 h-89 112 µM 0.454773107688172 0.316578664681882 no 1065 0.324636239561136 1671 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2567 aureobasidin a 60 nM 0.4542287279652 0.316780144012584 no 1066 0.324832104030727 1618 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3197 9113331 49.47 µM 0.453723966857218 0.316967008745131 no 1067 0.325013757246241 1644 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3084 9116877 49.47 µM 0.453151807079011 0.317178881218177 no 1068 0.325219716176697 1571 27241325 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.451248370088566 0.317884160688646 no 1069 0.325905275722479 1595 364106 SGTC_2619 obliquin 87.91 µM 0.450951357956258 0.317994272127066 no 1070 0.326012303553934 1626 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2801 7907800 81.82 µM 0.449546939308824 0.318515150678056 no 1071 0.326518577528984 1552 6620925 SGTC_1333 1482-0047 286 µM 0.448818357099034 0.318785512734737 no 1072 0.326781347598847 1593 3811116 SGTC_3090 9117696 49.47 µM 0.448157056352683 0.31903099153791 no 1073 0.327019926377353 1654 7923821 SGTC_1884 5633444 25 µM 0.448085017532151 0.319057737577224 no 1074 0.327045920238035 1580 5724239 SGTC_90 0870-0863 4.608 µM 0.44732957208665 0.319338270477567 no 1075 0.32731855911 1529 1738164 SGTC_2735 sertaconazole 140 nM 0.446973106181665 0.31947067919394 no 1076 0.3274472390067 1624 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2909 7941780 10.49 µM 0.446591701130933 0.319612377011629 no 1077 0.327584944340446 1644 1243215 SGTC_626 0214-0009 33 µM 0.446316901909855 0.319714485456416 no 1078 0.327684174447666 1663 3437874 SGTC_1809 st050081 57.6 µM 0.445557271626714 0.319996815951552 no 1079 0.327958540548839 1618 5036894 SGTC_408 cantharidin 100 µM 0.444382745818232 0.320433555198314 no 1080 0.3283829429414 1577 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2139 5578692 56.4705 µM 0.442488548243293 0.321138423369341 no 1081 0.329067857668618 1654 650991 YMR113W FOL3 SGTC_182 3448-4371 550.524 µM 0.439724675153771 0.322168071503102 no 1082 0.330068264429654 1701 3491403 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.439310447753493 0.322322504923185 no 1083 0.330218302447858 1608 140250 A respiratory chain inhibitor. SGTC_3337 9144342 33.5465 µM 0.438961532894106 0.322452612139293 no 1084 0.330344704686235 1634 17682949 SGTC_3176 9106582 49.47 µM 0.438001242123457 0.322810808200641 no 1085 0.330692691503229 1549 17018027 SGTC_2251 lansoprazole 556 µM 0.437135504508005 0.323133876164567 no 1086 0.331006539969858 1503 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_802 4112-3352 742 µM 0.43705279162856 0.323164749180651 no 1087 0.331036531384025 1671 704594 SGTC_2582 agaric acid 100 µM 0.435671147731032 0.323680634984086 no 1088 0.331537671040362 1500 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1811 st050069 61.5 µM 0.435016893673334 0.323925042300596 no 1089 0.331775082555831 1596 3877702 SGTC_3116 9124943 49.47 µM 0.434596518740424 0.324082120314793 no 1090 0.331927661180595 1489 41905195 YPL160W CDC60 SGTC_3063 1327-0034 4 µM 0.433967406672807 0.324317253913038 no 1091 0.332156054779274 1558 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3068 9116768 49.47 µM 0.433617273869644 0.324448148056172 no 1092 0.33228319442888 1545 41904888 SGTC_3349 9149703 23.001 µM 0.43309889048927 0.324641981062389 no 1093 0.332471464396183 1527 4910494 SGTC_1831 st055328 12 µM 0.43306917577384 0.324653093376776 no 1094 0.332482257668097 1666 1103068 SGTC_1793 st048256 72.231 µM 0.43213309138121 0.32500323764114 no 1095 0.332822342537452 1547 672022 SGTC_254 nsc-64875 3.808 µM 0.43159326893341 0.325205229638593 no 1096 0.333018525722207 1699 56993 SGTC_1870 st057514 26.5 µM 0.430829773029373 0.325491003984423 no 1097 0.333296074729107 1563 5393161 SGTC_1882 5615643 20 µM 0.429445782319791 0.326009289295607 no 1098 0.333799421114116 1546 2253075 SGTC_1111 tnp00062 510.699 nM 0.428643045927385 0.326310057114529 no 1099 0.334091507111894 1699 676306 SGTC_2270 7924575 90.91 µM 0.428633452920749 0.326313652088444 no 1100 0.334094998259294 1719 1262135 SGTC_1262 0737-0114 49.6 µM 0.427637976673051 0.326686793924994 no 1101 0.334457356233228 1639 765919 SGTC_3133 9127736 49.47 µM 0.426946477048503 0.326946096026458 no 1102 0.334709156135903 1706 27243420 SGTC_149 3970-0822 46.1 µM 0.426497368036718 0.32711455002157 no 1103 0.334872732723536 1609 3114250 YBL034C STU1 SGTC_2076 5212012 200 µM 0.424866564855013 0.327726535609989 no 1104 0.335466974774601 1576 604802 SGTC_427 1354-0053 47.3 µM 0.424329788774948 0.327928070986723 no 1105 0.335662658688938 1671 6813657 SGTC_3125 9127534 49.47 µM 0.423755040556915 0.328143918762947 no 1106 0.33587223491778 1560 1639235 SGTC_1219 1469-0211 33.1 µM 0.4236616033748 0.328179014698682 no 1107 0.335906310683772 1676 6822282 SGTC_209 4077-0173 175.592 µM 0.422510437180242 0.328611528555887 no 1108 0.336326242065434 1598 15993494 SGTC_3330 9141424 71.43 µM 0.421132890459579 0.329129399546707 no 1109 0.3368290227706 1691 27261020 SGTC_1921 5740136 50 µM 0.420692419829877 0.329295058092456 no 1110 0.336989848523176 1737 1774243 SGTC_656 4090-1979 187 µM 0.41915776977036 0.329872493068549 no 1111 0.337550416493869 1715 22330961 SGTC_1232 0279-0259 161 µM 0.418147435235105 0.33025286804786 no 1112 0.337919662538311 1579 1560000 SGTC_1751 st044839 27.194 µM 0.416333026755662 0.330936404519367 no 1113 0.338583164251131 1625 5291326 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.416158940841784 0.331002017051267 no 1114 0.338646851224472 1594 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_191 3914-0123 66.505 µM 0.415689920497963 0.331178815435095 no 1115 0.338818458921019 1553 3144412 SGTC_1652 st011932 78 µM 0.414525626201082 0.331617861697102 no 1116 0.339244601770298 1681 1551076 SGTC_582 0987-0078 156 µM 0.413463504837697 0.332018581231945 no 1117 0.339633527792451 1604 1625765 SGTC_1454 4239-0054 42.6 µM 0.412497098449081 0.332383356226892 no 1118 0.33998755349184 1684 1340767 SGTC_3126 9127922 49.47 µM 0.412082537316037 0.332539883128427 no 1119 0.340139463829627 1627 45595682 SGTC_882 0843-0131 351 µM 0.41182220133253 0.332638193777647 no 1120 0.340234873708784 1635 5425421 SGTC_1050 3232-1156 69.3 µM 0.408277034262704 0.333978098062019 no 1121 0.341535148960075 1579 700529 SGTC_481 bay k-8644 50 µM 0.407289271225063 0.334351803666044 no 1122 0.341897770866595 1572 2303 A calcium channel antagonist. SGTC_1008 4106-0037 6 µM 0.40706312268856 0.334437386753014 no 1123 0.341980813759963 1619 2905394 SGTC_1817 st052116 64.4 µM 0.406963785991103 0.334474982204874 no 1124 0.342017293117539 1661 4361398 SGTC_2593 nobiletin 86.24 µM 0.406962682819813 0.334475399725791 no 1125 0.34201769824277 1576 72344 An anti-infammatory. SGTC_3231 9132313 49.47 µM 0.406119080330955 0.334794740677234 no 1126 0.342327553444365 1639 4905967 SGTC_2018 5133068 143 µM 0.405658032293369 0.334969318326474 no 1127 0.342496941274713 1602 785362 SGTC_1712 st032288 53.4 µM 0.404726570707977 0.335322128694163 no 1128 0.34283925443302 1591 2883011 SGTC_2588 indole-3-carbinol 100 µM 0.404219751416542 0.335514158055708 no 1129 0.343025565317754 1749 3712 Induces cell cycle arrest. SGTC_1695 st026914 34.495 µM 0.403534535893229 0.335773848496273 no 1130 0.343277516789918 1592 3289191 SGTC_3215 9129942 49.47 µM 0.402578640366233 0.336136255216497 no 1131 0.343629112777543 1727 17682944 SGTC_2252 omeprazole 400 µM 0.402485884663262 0.336171429611508 no 1132 0.343663237241408 1694 4594 A proton pump inhibitor. SGTC_764 1951-2361 146 µM 0.401358333092507 0.336599129202159 no 1133 0.344078160897024 1560 5438930 SGTC_795 0685-0265 78 µM 0.401063096810475 0.336711152328695 no 1134 0.344186834881978 1618 302754 SGTC_1736 st036774 51 µM 0.400060459155206 0.337091696763958 no 1135 0.344555993357345 1820 1272247 SGTC_2035 5154463 94.595 µM 0.399422737416811 0.337333826594265 no 1136 0.344790871496145 1695 2769623 SGTC_2676 harmalol 100 µM 0.397508491071007 0.338061030921745 no 1137 0.345496263150419 1686 5459187 A monoamine oxidase inhibitor SGTC_3174 9107204 49.47 µM 0.397456667821385 0.338080726509392 no 1138 0.345515367272914 1678 3938802 SGTC_2370 9071495 200 µM 0.397398986411444 0.338102649030315 no 1139 0.345536631410338 1590 21791103 SGTC_1681 tripelennamine 100 µM 0.396710775718241 0.338364254201647 no 1140 0.345790376503291 1578 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_3314 9135860 59.4275 µM 0.39474169268471 0.339113179959503 no 1141 0.346516764971923 1753 25252478 SGTC_1365 1672-3266 55.4 µM 0.394181281291198 0.339326444596476 no 1142 0.346723602308079 1721 6415873 SGTC_441 propafenone 146 µM 0.39417241238269 0.339329820074837 no 1143 0.346726876023348 1602 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1354 1498-1681 81 µM 0.393875765209773 0.339442730471066 no 1144 0.346836381814496 1644 5754243 SGTC_2642 cholecalciferol 100 µM 0.393128082223938 0.339727378886048 no 1145 0.347112441926062 1684 9821465 A vitamin D precursor, similar to steriods. SGTC_2682 pyrogallin 40.03 µM 0.393099890548459 0.339738113453966 no 1146 0.3471228524676 1676 822798 An ATP competetive kinase inhibitor. SGTC_343 4130-2827 29.8 µM 0.392914858728945 0.339808571400854 no 1147 0.347191183353586 1605 1118244 SGTC_1872 amphotericin b 148 nM 0.392449757891 0.339985701056797 no 1148 0.347362963595982 1711 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_62 0180-0423 3.232 µM 0.392155907298556 0.34009762974277 no 1149 0.347471510476343 1694 30102 YGL099W LSG1 SGTC_2840 9008771 71.43 µM 0.392139555544676 0.340103858595243 no 1150 0.347477551096656 1784 2992978 SGTC_968 1309-0633 340 µM 0.391746534801765 0.340253584605409 no 1151 0.347622751397954 1731 3761976 SGTC_3042 9091578 49.47 µM 0.391665808503239 0.340284341385241 no 1152 0.347652578248308 1652 25236497 SGTC_1181 1222-0449 220 µM 0.39000877496051 0.340915906896707 no 1153 0.348265029123741 1713 658318 SGTC_1242 0402-0103 60.1 µM 0.389003890213012 0.341299128358814 no 1154 0.348636634314068 1599 432868 SGTC_3 0833-0587 95.581 µM 0.388570285591812 0.341464537806244 no 1155 0.348797025680397 1643 5382644 SGTC_1644 st010134 20.9 µM 0.388185087768399 0.341611506803619 no 1156 0.348939533928173 1724 3818134 SGTC_1903 st060211 78.3 µM 0.387963087364484 0.341696220105392 no 1157 0.349021675144602 1762 688960 SGTC_3043 9092303 49.47 µM 0.387900740288505 0.341720012607422 no 1158 0.349044745134998 1558 25236084 SGTC_3030 9087619 49.47 µM 0.387418805241419 0.341903946861782 no 1159 0.34922309207542 1616 25236973 SGTC_595 3909-8003 73.7 µM 0.382827835690152 0.343658002304414 no 1160 0.350923710503 1669 699517 SGTC_2198 6589944 200 µM 0.382661936967971 0.343721449978714 no 1161 0.35098522003389 1696 5290268 SGTC_2711 st079103 59.1 µM 0.382001096034543 0.34397423110978 no 1162 0.351230275829684 1751 54693780 SGTC_2333 9017922 200 µM 0.380709297049665 0.344468564095397 no 1163 0.351709484721509 1788 3163164 SGTC_1613 st002381 52.1 µM 0.380552405224162 0.344528620038538 no 1164 0.351767701761884 1633 551167 SGTC_1867 st057372 64 µM 0.38009618982958 0.34470327501881 no 1165 0.351937006999959 1661 688837 SGTC_3323 9138564 53.9225 µM 0.378867137432859 0.345173963285517 no 1166 0.352393264338245 1785 43912313 YNL103W MET4 SGTC_1138 3761-0006 1.03 µM 0.37762715975912 0.345649078421417 no 1167 0.352853792778165 1680 12061087 SGTC_2102 5377816 72.7585 µM 0.377348540901137 0.345755868704153 no 1168 0.352957301685777 1788 1379702 SGTC_906 1165-0455 526 µM 0.373803313325061 0.347115768493037 no 1169 0.354275327119017 1616 3252859 SGTC_2051 5263410 176 µM 0.372941265708587 0.347446736504494 no 1170 0.354596079207757 1709 227584 SGTC_1144 3486-0183 12.5 µM 0.372107402898705 0.347766994160547 no 1171 0.354906442382842 1678 6744069 SGTC_2432 5630864 12.22 µM 0.37188095919141 0.347853982068734 no 1172 0.354990741214933 1626 5714970 SGTC_2960 9079389 5.97 µM 0.371753435592028 0.347902973535968 no 1173 0.355038217906784 1786 16457355 SGTC_817 1391-0715 46 µM 0.371514385441023 0.347994817634456 no 1174 0.355127221696489 1628 1353946 SGTC_2069 5228469 200 µM 0.371376884047244 0.348047650303147 no 1175 0.355178420163477 1630 2835210 SGTC_1398 3558-0053 112 µM 0.371252292594641 0.348095525084731 no 1176 0.355224813888327 1656 4532369 SGTC_2572 astragaloside iv 100 µM 0.369793760696341 0.348656151895664 no 1177 0.355768082236494 1696 45006101 An anti-inflammatory agent. SGTC_1313 1220-0047 237 µM 0.36758195380211 0.349506951291709 no 1178 0.35659248646837 1732 3528706 SGTC_702 1488-0190 94 µM 0.367364043629847 0.349590814194989 no 1179 0.356673744217188 1811 949357 SGTC_607 4491-0986 66.8 µM 0.366232713933097 0.350026325239127 no 1180 0.357095716587206 1782 698981 YDR232W HEM1 SGTC_2359 9039622 200 µM 0.364928725513677 0.350528546929302 no 1181 0.357582305495471 1745 6463596 SGTC_2606 farnesol 9.78 µM 0.364033862995962 0.350873348040645 no 1182 0.357916361355944 1769 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1419 3993-2473 62.6 µM 0.363685246580656 0.351007707335427 no 1183 0.358046530771134 1712 704026 SGTC_3004 9076122 71.4286 µM 0.362841207372421 0.351333083294278 no 1184 0.358361753764482 1767 44782551 SGTC_1400 3771-8998 51.5 µM 0.362641585722464 0.351410053111994 no 1185 0.358436320509433 1742 670767 SGTC_1950 st077106 7.18 µM 0.361451205205715 0.351869164671644 no 1186 0.358881087672524 1646 13831864 SGTC_1574 spiramycin 23.7 µM 0.360554400900778 0.352215191131446 no 1187 0.359216291101374 1626 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1988 st071872 53.4 µM 0.359766740811214 0.352519205925144 no 1188 0.359510788527803 1819 16414116 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.359681784458718 0.352552002337688 no 1189 0.359542557761211 1738 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1750 st081859 2.357 µM 0.359475805830402 0.352631522543292 no 1190 0.359619587027218 1723 5291695 SGTC_1019 4262-0212 3.4 µM 0.358515608182114 0.353002301831838 no 1191 0.359978744746473 1818 4677213 SGTC_1160 4092-0570 10.5 µM 0.35837009347227 0.353058504372146 no 1192 0.36003318468276 1620 4994975 SGTC_750 4073-0104 132 µM 0.357734762048122 0.353303927687237 no 1193 0.360270908001746 1636 22330957 SGTC_2009 4012297 12.05 µM 0.35718671503514 0.353515682774245 no 1194 0.360476015339204 1659 45595307 SGTC_2016 5121758 140 µM 0.356648653554826 0.35372362375285 no 1195 0.360677424641806 1664 2795203 SGTC_1182 1222-0449 220 µM 0.356268506609414 0.353870562888429 no 1196 0.360819746055754 1705 658318 SGTC_3157 9099274 49.47 µM 0.356163899817634 0.353911000629724 no 1197 0.36085891267974 1824 17217662 SGTC_210 3551-0445 56.827 µM 0.355734412981817 0.35407704418881 no 1198 0.361019735401308 1736 2865180 YOR207C RET1 SGTC_196 k015-0023 18.111 µM 0.354972257013924 0.354371768996022 no 1199 0.361305187623233 1680 5211998 SGTC_218 alverine citrate 93.75 µM 0.354801352337562 0.354437869610966 no 1200 0.361369207595193 1761 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1733 st037357 54.9 µM 0.354371312983086 0.354604214855468 no 1201 0.361530315193293 1593 1272339 YGL099W LSG1 SGTC_3105 9121040 49.47 µM 0.354311992805393 0.354627162908164 no 1202 0.361552540508769 1720 41448907 SGTC_1119 parthenolide 318.541 nM 0.354219931960496 0.3546627777559 no 1203 0.36158703359816 1768 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_482 fipronil 114 µM 0.353596806912022 0.35490387458219 no 1204 0.361820533837979 1739 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2505 galangin 7.89 µM 0.352455460689319 0.355345629943543 no 1205 0.36224835764094 1648 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_21 0849-0113 22.993 µM 0.35216524808342 0.355457987076722 no 1206 0.362357168805977 1661 1560156 SGTC_2117 5521686 200 µM 0.351879899507321 0.35556847332787 no 1207 0.36246416711433 1659 803312 SGTC_2202 7226349 200 µM 0.351305159424093 0.355791048077392 no 1208 0.362679712331238 1684 844334 SGTC_2303 7774051 200 µM 0.351231317231754 0.355819647887062 no 1209 0.362707408582184 1782 2953184 SGTC_1834 st055981 52.8 µM 0.349586702248739 0.35645683354012 no 1210 0.36332444602899 1813 471719 YDL150W RPC53 SGTC_1904 st060225 78 µM 0.349574197923413 0.356461679723529 no 1211 0.363329138845005 1681 66595 SGTC_719 2810-4230 27.3 µM 0.349446130242889 0.356511315040508 no 1212 0.363377203239656 1716 721079 SGTC_588 3970-1144 52.9 µM 0.348930963945972 0.356711003093437 no 1213 0.363570569263911 1772 1888707 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.348718875880825 0.356793223794642 no 1214 0.363650185945837 1746 7104 SGTC_136 0097-0015 404.482 µM 0.347243681415679 0.357365299958349 no 1215 0.364204128507917 1792 4861337 SGTC_1140 3229-1848 2.98 µM 0.346488521211581 0.357658273101589 no 1216 0.364487804671183 1810 2849525 SGTC_2296 7971656 126.45 µM 0.345657214792808 0.357980885051765 no 1217 0.364800171018261 1668 666570 SGTC_3213 9129884 49.47 µM 0.344862411234851 0.358289425908177 no 1218 0.365098905232231 1588 17190742 SGTC_2466 5983409 37.09 µM 0.343090413124423 0.358977644313046 no 1219 0.365765221563858 1695 2879657 SGTC_167 3672-0051 66.205 µM 0.342377206887657 0.359254772678083 no 1220 0.366033519709674 1653 3237971 SGTC_2794 7785382 27.27 µM 0.341955353111829 0.359418725979066 no 1221 0.366192246008815 1883 2205081 SGTC_2687 chenodiol 100 µM 0.341693161996795 0.359520639496611 no 1222 0.366290909327938 1752 5702181 A cholesterol synthesis inhibitor. SGTC_1668 st014914 51.6 µM 0.340591022050862 0.35994914979603 no 1223 0.366705744569421 1725 2839556 SGTC_303 1348-1668 34.2 µM 0.340411761815967 0.36001886255872 no 1224 0.366773231195288 1748 5380509 SGTC_3160 9100216 49.47 µM 0.338071181050356 0.360929520779357 no 1225 0.367654773722504 1750 17191039 SGTC_2885 9057732 51.95 µM 0.334640725926615 0.362265644779537 no 1226 0.368948059778588 1732 6471414 SGTC_2339 9000433 200 µM 0.333814569849213 0.362587674955133 no 1227 0.369259744164622 1647 2988954 SGTC_684 1140-0066 328 µM 0.331057033307787 0.363663247229492 no 1228 0.370300702877263 1717 6813534 SGTC_142 0335-0849 62.6745 µM 0.329549038349415 0.364251893427243 no 1229 0.370870367348155 1746 3889043 YPR107C YTH1 SGTC_956 1185-0240 191 µM 0.325970356684809 0.365650112685088 no 1230 0.372223391586193 1755 1416193 SGTC_2353 9059630 146.67 µM 0.325088072745735 0.365995103301122 no 1231 0.372557207850107 1814 4779114 SGTC_1280 0880-0253 10.1 µM 0.324259545224464 0.366319172765475 no 1232 0.372870772310615 1737 6836607 SGTC_353 1988-1175 58.3 µM 0.32374830319049 0.366519187076654 no 1233 0.373064298976538 1683 2788357 SGTC_2435 5706476 10.6 µM 0.323449758814144 0.366636004002153 no 1234 0.373177325428932 1902 5725375 SGTC_2507 purpurin 79.67 µM 0.323412634325649 0.366650531244535 no 1235 0.373191381219014 1641 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_3001 9076041 71.4286 µM 0.323388862440097 0.366659833559038 no 1236 0.373200381637259 1736 16004211 SGTC_3128 9127691 49.47 µM 0.322693503443924 0.366931973154909 no 1237 0.373463686332669 1762 41316314 SGTC_2474 5321570 43.32 µM 0.322132305819244 0.367151655385008 no 1238 0.373676232565326 1846 2841384 SGTC_2558 carylophyllene oxide 100 µM 0.321950606066575 0.367222791538403 no 1239 0.373745057199113 1775 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2823 7987624 58.44 µM 0.320762759159166 0.367687950373765 no 1240 0.374195091579699 1749 2239440 SGTC_1105 epirubicin 18.1 µM 0.317527277142476 0.368955942531043 no 1241 0.375421772669105 1700 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2759 disulfiram 3.38 µM 0.31402513610755 0.370330047720527 no 1242 0.37675097393 1714 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2946 9065502 71.43 µM 0.310810887279618 0.37159265350361 no 1243 0.377972196246141 1751 16489101 SGTC_2744 captopril 92.04 µM 0.308759812682064 0.372399070376223 no 1244 0.378752120617759 1887 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_794 k038-0031 316 µM 0.307518579294665 0.372887355737603 no 1245 0.379224341741388 1745 6624242 SGTC_2998 9066762 71.4286 µM 0.30721037509534 0.373008631024622 no 1246 0.379341624475483 1867 4945196 SGTC_1893 st059353 36.1 µM 0.306391705607164 0.373330830409939 no 1247 0.379653211430741 1735 3112488 SGTC_2879 9041815 71.43 µM 0.304398078547833 0.37411582170712 no 1248 0.380412315740284 1827 4942971 SGTC_3155 9099265 49.47 µM 0.303469407492955 0.37448166474458 no 1249 0.380766079082603 1813 25236499 SGTC_1784 st039334 36.3 µM 0.302587053504075 0.374829366242353 no 1250 0.381102291013055 1876 3496984 SGTC_728 3030-5151 22.5 µM 0.302301394066878 0.374941955372956 no 1251 0.381211157858246 1800 3125388 SGTC_348 k064-0012 10.7 µM 0.301478219199074 0.375266459136365 no 1252 0.381524928214124 1736 5066323 SGTC_1300 1094-0077 113 µM 0.299979764020308 0.375857391652875 no 1253 0.382096295590562 1747 5532636 SGTC_1762 st045503 25.4615 µM 0.29962903679183 0.375995746964017 no 1254 0.382230066528303 1752 4645554 SGTC_107 0358-0022 2.6945 µM 0.298654230404495 0.376380373469263 no 1255 0.382601941405642 1875 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3319 9138450 16.7555 µM 0.298464492660208 0.376455252023282 no 1256 0.382674336275944 1788 2029690 SGTC_858 0438-0351 2.77 µM 0.298042545734911 0.376621786822451 no 1257 0.382835345783417 1760 2799119 SGTC_3018 9082602 49.47 µM 0.297777307481673 0.376726483307476 no 1258 0.382936567648619 1802 17332089 SGTC_1614 st002383 48.6 µM 0.297549617981877 0.37681636554895 no 1259 0.383023466303577 1802 1947235 SGTC_2281 7943571 200 µM 0.297452596355152 0.376854667637023 no 1260 0.383060496804475 1955 1244024 SGTC_2887 9044784 58.44 µM 0.296598643986747 0.377191842229148 no 1261 0.383386473126565 1827 6465546 SGTC_55 0767-0285 6.563 µM 0.294491661022088 0.378024163589646 no 1262 0.384191117299137 1912 3116166 SGTC_1735 st034310 56.75 µM 0.294107871552506 0.37817583302462 no 1263 0.384337738065246 1871 871153 SGTC_784 4579-0127 173 µM 0.291403238825811 0.379245205668851 no 1264 0.385371468879632 1931 1948547 SGTC_855 0428-0020 25 µM 0.291015104837777 0.379398744290896 no 1265 0.38551988362382 1799 6812414 SGTC_150 3970-0969 77.2 µM 0.290750759903754 0.379503325145472 no 1266 0.38562097348567 1803 6615640 SGTC_2153 5569715 200 µM 0.289524814605547 0.379988452070429 no 1267 0.386089896655975 1818 2054701 SGTC_699 0375-0592 111 µM 0.289016879758346 0.380189505720503 no 1268 0.38628423017073 1959 762578 SGTC_1126 isoteolin 1.0172 µM 0.288654908991748 0.380332802802518 no 1269 0.386422735918951 1713 133323 SGTC_384 k007-0144 5.16 µM 0.288367551881536 0.380446573506868 no 1270 0.386532701545091 1819 6824886 SGTC_2657 nystatin 74.44 µM 0.288256078222914 0.380490711050052 no 1271 0.386575362663624 1846 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2093 5331342 194.4 µM 0.286771555698881 0.381078649836681 no 1272 0.387143621920068 1911 33839 SGTC_460 trequinsin 123 µM 0.285436964125348 0.381607443595708 no 1273 0.387654695801332 1850 5537 A vasodilator. SGTC_2937 9044753 11.33 µM 0.284711195408868 0.38189510155321 no 1274 0.387932706395889 1778 6465530 YGL099W LSG1 SGTC_545 4218-0007 221 µM 0.284549621926734 0.381959149979218 no 1275 0.387994606029953 1811 2840508 SGTC_3113 9123498 49.47 µM 0.284212512120696 0.38209279216299 no 1276 0.388123763696329 1926 8897275 SGTC_516 3992-2719 87.3 µM 0.283124128225859 0.382524361648951 no 1277 0.388540843163824 1690 5350887 YDR037W KRS1 SGTC_1375 2910-0797 186 µM 0.28286671985269 0.382626451404972 no 1278 0.388639503409277 1824 742508 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.282723757401336 0.382683154722745 no 1279 0.388694301585366 1794 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_34 0469-0683 81.75 µM 0.281596983883751 0.38313015578684 no 1280 0.389126276584472 1875 3690923 SGTC_1421 4029-0249 71.4 µM 0.280119095448778 0.38371668315693 no 1281 0.38969306744252 1942 2894095 SGTC_1892 st058411 7.36 µM 0.278588416001315 0.384324442588747 no 1282 0.390280351792923 1920 3934738 SGTC_2376 9072922 81.32 µM 0.276302855289588 0.385232458333973 no 1283 0.391157731523533 1851 17087968 SGTC_16 erodoxin 22.806 µM 0.275141496011724 0.385694088859849 no 1284 0.391603766086807 1858 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1166 k206-0078 225 µM 0.274490674853307 0.385952855635896 no 1285 0.391853784457088 1786 5404595 SGTC_2866 9034245 58.44 µM 0.273849049918803 0.386208015672223 no 1286 0.392100313747842 1950 6462273 SGTC_3166 9102297 49.47 µM 0.273662637957908 0.386282156816284 no 1287 0.392171946285156 1776 25237072 SGTC_43 0570-0105 72.5 µM 0.273511367158106 0.386342324409954 no 1288 0.392230077812077 1820 1114046 YDL195W SEC31 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.273336238182847 0.386411984948582 no 1289 0.392297380749449 1873 5393153 SGTC_3168 9103419 49.47 µM 0.273122160224308 0.386497143082705 no 1290 0.392379656351167 1922 16649256 SGTC_255 tunicamycin 200.472 nM 0.272582795981998 0.386711721171933 no 1291 0.392586969062288 1948 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1693 xanthone 101.9 µM 0.271819937728147 0.387015272177952 no 1292 0.392880237069567 1883 7020 An insecticide. SGTC_1459 k035-0031 35.7 µM 0.270374025642294 0.38759080850904 no 1293 0.393436260370793 1736 3877128 YMR208W ERG12 SGTC_3267 9137951 49.47 µM 0.268865882666176 0.3881913787384 no 1294 0.394016446099911 1837 16643986 SGTC_478 N-arachidonylglycine 10 µM 0.268705595079003 0.388255223948181 no 1295 0.394078122921713 1928 5283389 SGTC_2638 epoxomicin 18 µM 0.268680423693769 0.388265250403636 no 1296 0.394087808822906 1933 9915668 A protesome inhibitor. SGTC_2653 dihydrofissinolide 100 µM 0.268387034587628 0.388382120849307 no 1297 0.394200709223224 1863 6857746 SGTC_2328 6201408 200 µM 0.265370188691513 0.389584454529428 no 1298 0.395362149552734 1801 2890418 SGTC_517 1365-0151 113 µM 0.26496008716051 0.389747978290353 no 1299 0.395520104516151 1855 768657 SGTC_818 4072-2707 53.5 µM 0.263834113103216 0.390197049127827 no 1300 0.395953873576348 1798 882871 SGTC_3033 9090887 49.47 µM 0.263385468134298 0.390376022511435 no 1301 0.396126745026917 1789 19325384 SGTC_1803 st050068 52.4 µM 0.260603659667073 0.391486258388103 no 1302 0.397199083588023 1877 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_11 0438-0307 1.3 µM 0.259743384389177 0.391829778731 no 1303 0.397530862472317 1976 4011476 SGTC_2664 lyso-paf C-16 73.48 µM 0.259280282256388 0.392014737043369 no 1304 0.397709495911714 1873 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2576 guaiol 23.12 µM 0.258523727167649 0.392316949983801 no 1305 0.39800136975683 1999 227829 SGTC_1331 1472-0049 76.2 µM 0.258034631796053 0.392512358244588 no 1306 0.39819008984355 1807 24051409 SGTC_2647 atorvastatin 60.16 µM 0.257748464066412 0.392626703400624 no 1307 0.39830052025308 1926 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1948 st076329 66.6 µM 0.257339532794609 0.392790117747543 no 1308 0.398458338511381 1933 24208413 SGTC_2561 acetosyringone 100 µM 0.257033104159105 0.392912583073397 no 1309 0.398576608961645 1955 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1023 4482-3888 16 µM 0.256277331779226 0.393214675562656 no 1310 0.398868349762612 1940 3303168 SGTC_2928 9011484 9.79 µM 0.255871475966253 0.393376928197833 no 1311 0.399025040238194 1839 2994751 SGTC_2080 5212524 12.4 µM 0.254614030014375 0.393879746151805 no 1312 0.399510610935264 2007 260183 SGTC_648 0375-0473 33.3 µM 0.25371418175683 0.39423967933543 no 1313 0.39985818851296 1855 1713139 SGTC_1669 st015249 58.4 µM 0.253108302915622 0.39448207765971 no 1314 0.400092261472037 2009 722793 SGTC_1927 st060202 13.8 µM 0.251493064743155 0.395128497112605 no 1315 0.400716461732725 1989 688887 SGTC_17 0960-0276 49.807 µM 0.249966241868929 0.395739798201356 no 1316 0.401306727565123 1897 6821114 SGTC_109 0132-0036 33.701 µM 0.24679976708501 0.397008390433749 no 1317 0.402531595377475 1989 67274 A color developer. SGTC_2831 7999036 19.48 µM 0.245940744724494 0.397352731203312 no 1318 0.402864051283862 1996 2988270 SGTC_1908 st060353 56.5 µM 0.245700201009425 0.397449167966762 no 1319 0.402957158291602 2023 4227716 SGTC_1742 st038235 28.8875 µM 0.245283522060782 0.397616234218115 no 1320 0.403118454802038 1861 564103 YBR002C RER2 SGTC_800 3448-7362 155 µM 0.245273368159502 0.397620305630773 no 1321 0.403122385585275 1931 15991913 SGTC_2514 salinomycin 42.74 µM 0.245078471871446 0.397698455411208 no 1322 0.403197835828615 2009 23682228 A polyether potassium ionophore. SGTC_1958 st076513 41.9 µM 0.242083886944518 0.398899742559283 no 1323 0.40435758164016 1856 732122 YGL099W LSG1 SGTC_2659 sanguinarine 24.21 µM 0.241841186474631 0.398997144746938 no 1324 0.404451611893893 1882 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3315 9136395 68.55 µM 0.241802286183758 0.399012757058738 no 1325 0.404466683676871 2018 16876844 SGTC_1062 mesoridazine 14.2 µM 0.240678968336435 0.399463661033664 no 1326 0.40490197035577 1889 4078 A neuroleptic. SGTC_357 1325-0123 420 µM 0.240411098055173 0.399571204993617 no 1327 0.405005787730743 2006 1098503 SGTC_677 0929-0063 136 µM 0.239750454897498 0.399836471083019 no 1328 0.405261859025766 1884 1539583 SGTC_39 0986-0283 58.349 µM 0.238824856298748 0.400208201683887 no 1329 0.405620697661238 1992 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_3139 9095020 49.47 µM 0.235360928673427 0.401600153066024 no 1330 0.406964304370466 1971 25236292 SGTC_2004 4023728 41.89 µM 0.234767606474266 0.401838700627924 no 1331 0.407194555697133 2018 360084 YDR527W RBA50 SGTC_660 4031-1742 102 µM 0.233661436582448 0.402283538254482 no 1332 0.4076239140867 1874 6738706 SGTC_1222 0366-0074 1.18 µM 0.232794430502539 0.402632286530994 no 1333 0.407960518970891 2001 286520 SGTC_2863 9028737 58.44 µM 0.231038354496692 0.403338895314626 no 1334 0.408642502696919 2040 6460917 SGTC_856 0433-0016 11.3 µM 0.230105940832697 0.403714207815506 no 1335 0.409004724317685 1897 3911780 SGTC_148 3253-0744 288.01 µM 0.229574717030477 0.403928074186755 no 1336 0.409211127525002 1976 6893655 SGTC_927 2425-1185 123 µM 0.229476188522669 0.403967744120158 no 1337 0.409249412840884 1846 730375 SGTC_1223 0764-0573 147 µM 0.227700494863877 0.404682849769809 no 1338 0.409939543849107 1904 1609797 SGTC_2935 9038016 29.96 µM 0.227673724759864 0.404693633043302 no 1339 0.409949950306324 2027 6463195 SGTC_1462 k081-0014 26.5 µM 0.227080215687066 0.404932723185468 no 1340 0.410180683909136 1932 3270634 SGTC_416 estradiol valerate 100 µM 0.226285487656579 0.40525292826133 no 1341 0.41048969242635 1911 13791 A steroid. SGTC_1605 st000082 49.1 µM 0.225686897007511 0.405494149220964 no 1342 0.410722474927704 1971 1114022 SGTC_1972 st070201 17.4 µM 0.22506965441595 0.405742924161309 no 1343 0.410962543810537 2019 2829099 SGTC_634 1611-4317 11.2 µM 0.224985035138832 0.405777032288293 no 1344 0.410995458034911 2054 2843522 SGTC_2815 7968870 71.43 µM 0.224688411081519 0.405896600419846 no 1345 0.411110840365053 1868 2977326 YHR190W ERG9 SGTC_235 0330-0087 5 mM 0.224411040981352 0.40600841529086 no 1346 0.411218740151178 1904 46494818 YHR062C RPP1 SGTC_751 0833-0568 350 µM 0.224024491540227 0.40616425589001 no 1347 0.411369123010462 1921 6954252 SGTC_2663 amphotericin b 100 µM 0.223007445245937 0.40657435746319 no 1348 0.411764855973189 1926 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1238 0333-0287 48.8 µM 0.222518896059793 0.406771390657587 no 1349 0.411954982521991 1901 7226 SGTC_2278 7948257 134.34 µM 0.222463664097103 0.40679366734184 no 1350 0.411976478204507 2074 1247028 SGTC_462 ag-879 158 µM 0.222217533674478 0.406892942687137 no 1351 0.412072272713138 2008 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.22211364577602 0.406934847092641 no 1352 0.412112707687402 1906 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1666 st014829 29 µM 0.21979691883304 0.407869602100318 no 1353 0.413014659687606 1898 3858230 SGTC_2260 7964312 200 µM 0.217135648700054 0.408944020962033 no 1354 0.414051316497818 2034 231951 SGTC_194 1486-1323 56.904 µM 0.216839458487717 0.409063642566704 no 1355 0.414166730019706 1879 5178754 SGTC_1434 4073-0095 163 µM 0.215433955198591 0.409631394956059 no 1356 0.414714499521246 2012 24133745 SGTC_3232 9132874 49.47 µM 0.215250628770275 0.409705463580336 no 1357 0.414785959934759 1884 3784940 SGTC_329 k048-0121 21.3 µM 0.21459187816574 0.409971642459677 no 1358 0.415042763356049 1917 6832902 SGTC_1345 1488-0192 31.4 µM 0.213839850945577 0.410275561983767 no 1359 0.415335973552639 2024 658348 SGTC_1680 diphenhydramine 100 µM 0.210559704328643 0.411601807618979 no 1360 0.416615429296683 1897 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_840 0245-0196 390 µM 0.209669118770371 0.411962068803108 no 1361 0.416962964713693 2024 3827528 SGTC_2666 tannic acid 100 µM 0.209409376128876 0.412067154330206 no 1362 0.417064336966869 1977 16134267 A thiamine antagonist. SGTC_760 0568-0725 82.9 µM 0.208925003872223 0.412263136349682 no 1363 0.417253392299446 2057 3916171 SGTC_3136 9095672 49.47 µM 0.2085311738113 0.412422500191466 no 1364 0.417407122212581 2082 17217380 SGTC_1772 st048439 82.2 µM 0.20850059578579 0.412434874233327 no 1365 0.417419058745136 1910 2927068 YDL195W SEC31 SGTC_2237 6667747 47.222 µM 0.208391878727798 0.412478869584696 no 1366 0.417461498488151 1885 729940 YDL015C TSC13 SGTC_2400 5203494 178.7 µM 0.208355863868615 0.412493444231757 no 1367 0.417475557776081 1962 6777674 SGTC_268 camptothecin 39.6153 µM 0.207679570533389 0.412767151892851 no 1368 0.417739585119939 1993 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2700 st077718 96.8 µM 0.207388109963341 0.412885124136076 no 1369 0.417853383814118 1882 904970 SGTC_1800 st050079 29.0735 µM 0.207199454314603 0.412961489020927 no 1370 0.41792704673017 1956 3645560 SGTC_1252 0493-0875 34.8 µM 0.2061550393418 0.413384311541559 no 1371 0.418334903416663 1925 3960963 SGTC_632 0781-2353 4.65 µM 0.203824662786439 0.41432810617146 no 1372 0.419245259638746 1990 6811515 YHR007C ERG11 SGTC_1861 st057647 17.4 µM 0.202412805920898 0.41490014453244 no 1373 0.419797008962747 2049 688668 SGTC_2861 9024595 19.48 µM 0.202167771877133 0.414999442750506 no 1374 0.419892783603433 2073 16482810 SGTC_1474 0330-0125 5.35 µM 0.20211779593215 0.41501969579629 no 1375 0.419912317913371 2029 X1474 SGTC_244 nsc-207895 1.295 µM 0.201636210734972 0.415214872597728 no 1376 0.420100567270569 1918 42640 SGTC_1269 0831-0796 3.05 µM 0.201351866400507 0.415330121469564 no 1377 0.420211724701017 2043 927758 SGTC_3097 9117246 49.47 µM 0.200835414136669 0.415539465668587 no 1378 0.420413635294309 2034 16423892 SGTC_2241 6772625 37.8075 µM 0.200776014623032 0.415563544831382 no 1379 0.420436859289917 2094 2285411 SGTC_1606 st000094 49.2 µM 0.200724644690746 0.415584369246831 no 1380 0.420456944106698 2080 1242210 SGTC_293 4049-0273 38.5 µM 0.199473999474538 0.416091430577271 no 1381 0.420945990033534 1998 1380311 SGTC_3056 9094900 49.47 µM 0.199304938786428 0.416159985243962 no 1382 0.421012108040986 1874 25236784 SGTC_2798 7813637 45.45 µM 0.199087217636323 0.416248275646092 no 1383 0.421097259968382 1970 956368 SGTC_2641 levomentholum 100 µM 0.198541600843496 0.416469553029248 no 1384 0.421310669873797 2023 16666 SGTC_697 0508-1955 564 µM 0.197466351695035 0.416905702664638 no 1385 0.421731305226566 2072 6243113 SGTC_457 grayanotoxin iii 135 µM 0.197358082938823 0.41694962502745 no 1386 0.421773664708644 1986 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_161 4065-0411 162.148 µM 0.197166410123493 0.41702738520888 no 1387 0.42184865773295 1964 1906281 YLR208W SEC13 SGTC_504 lovastatin 124 µM 0.194350111973986 0.418170308309315 no 1388 0.422950874958018 1888 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2858 9025781 8.96 µM 0.192234325992772 0.419029401673682 no 1389 0.423779329519506 2062 4894980 YPL153C RAD53 SGTC_2489 cantharidin 73.42 µM 0.191220492666423 0.419441195506861 no 1390 0.424176424510464 2004 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1407 3909-7909 12.3 µM 0.190625318217838 0.419682981674544 no 1391 0.42440957642344 1965 4411780 SGTC_981 1488-1094 54.9 µM 0.19029236425816 0.419818255522362 no 1392 0.424540018386253 1988 3449522 SGTC_2396 5342950 42.78 µM 0.188955308769349 0.420361574960187 no 1393 0.425063922078504 1943 1886677 SGTC_2685 mycophenolic acid 18.85 µM 0.184702826141528 0.422090597521038 no 1394 0.426731064689338 2042 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_463 ikarugamyin 104 µM 0.184379663294259 0.422222054586478 no 1395 0.426857811324412 2085 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1137 ixabepilone 100 µM 0.184096470021365 0.422337259843572 no 1396 0.426968887833906 1909 154225 A novel microtubule stabilizer. SGTC_797 k781-0471 270 µM 0.181400541565973 0.42343431614997 no 1397 0.42802659691104 2033 23738129 SGTC_129 0088-0017 176.636 µM 0.180328771483171 0.423870617842646 no 1398 0.428447234762062 2096 182446 SGTC_3355 9151058 44.0485 µM 0.17781386430779 0.424894764782941 no 1399 0.429434579361489 2109 17015728 SGTC_2108 5365811 200 µM 0.17384937722893 0.426510252205792 no 1400 0.430991918893624 2041 780283 SGTC_1228 0124-0032 52.5 µM 0.173830643481919 0.426517888963631 no 1401 0.430999280497615 2073 X1228 SGTC_1367 1812-0510 76.9 µM 0.173428600188887 0.426681787385602 no 1402 0.43115727300565 2052 1142582 YDR527W RBA50 SGTC_2671 danthron 100 µM 0.172961402007894 0.426872262987533 no 1403 0.43134088351956 2003 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2782 7736369 71.43 µM 0.172713137398668 0.426973486827594 no 1404 0.431438458416168 1973 2950836 YOL077C BRX1 SGTC_2048 5246248 200 µM 0.172074935225451 0.427233720255012 no 1405 0.431689308809147 2126 677046 SGTC_274 sirtinol 40.1 µM 0.172066997008534 0.427236957343331 no 1406 0.431692429161529 1914 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1067 clotrimazole 1.36 µM 0.171809548537613 0.427341943705028 no 1407 0.43179362925358 1983 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_88 0180-0332 8.668 µM 0.171606162844553 0.427424887140869 no 1408 0.431873581042416 2075 3101745 SGTC_1077 5-fluorocytosine 377 nM 0.17086416942363 0.427727509264346 no 1409 0.432165285477177 2019 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_937 3122-0005 46.7 µM 0.166375008095323 0.429559314985196 no 1410 0.433930920242009 2116 759535 SGTC_3248 9135562 49.47 µM 0.164781025363155 0.430210108026571 no 1411 0.434558169718285 1990 17650701 SGTC_1961 st076550 68.7 µM 0.163866315377702 0.430583652584998 no 1412 0.434918192516492 2027 1579337 SGTC_1865 st057639 52.2 µM 0.163400656490898 0.430773839848841 no 1413 0.435101493012834 2130 688818 SGTC_1025 k007-0731 70 µM 0.160290290509709 0.432044604347027 no 1414 0.436326203517952 1920 6256118 SGTC_2919 7978188 46.38 µM 0.160107472399387 0.432119318140086 no 1415 0.436398207494731 2126 2980291 SGTC_1783 st039459 87.517 µM 0.160010875920881 0.43215879600436 no 1416 0.436436253431157 2132 729761 SGTC_2948 9070189 9.45 µM 0.15996026567341 0.432179480097986 no 1417 0.436456187252423 2147 6473636 YDL196W YDL196W SGTC_2614 arthonioic acid 13.39 µM 0.159488599508648 0.43237225606 no 1418 0.436641969814332 2100 6710684 SGTC_3199 9111318 49.47 µM 0.157511614891304 0.433180449478879 no 1419 0.437420827396943 2075 8548020 SGTC_3268 9137683 49.47 µM 0.157107563039578 0.433345660820207 no 1420 0.437580038580968 2003 1953228 SGTC_1076 itraconazole 331 nM 0.156634246427185 0.433539208399022 no 1421 0.437766555462519 2124 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_484 loperamide 105 µM 0.156625891091846 0.43354262518751 no 1422 0.437769848120959 2110 3955 An opioid-receptor agonist. SGTC_1004 4084-0029 199 µM 0.156237297016895 0.433701540361923 no 1423 0.437922989467498 2135 716894 YLR208W SEC13 SGTC_71 0417-1750 47.813 µM 0.155370004947714 0.43405625723963 no 1424 0.438264814785592 2147 6811472 SGTC_949 1165-0505 146 µM 0.155063544231145 0.434181610414459 no 1425 0.438385610996552 1978 6244267 SGTC_3328 9140624 29.0385 µM 0.155058239611107 0.434183780248297 no 1426 0.438387701944805 2126 4904392 SGTC_2146 5545642 200 µM 0.15438021974974 0.434461137892186 no 1427 0.438654974517624 2123 825326 SGTC_1874 staurosporine 7.6 µM 0.154123884068279 0.434566005563242 no 1428 0.438756028257933 2111 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2273 7815444 169.05 µM 0.153520422538168 0.434812901590985 no 1429 0.438993943174997 2163 2824616 SGTC_3283 9109332 35.8195 µM 0.152937932576524 0.435051241571203 no 1430 0.439223610951479 2116 17027281 SGTC_1290 0986-0249 10.2 µM 0.152636686178837 0.435174513149425 no 1431 0.439342396292709 2143 53329 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.15210087358451 0.435393785986094 no 1432 0.43955368760221 2142 4000243 SGTC_1759 st043059 70 µM 0.151752657417831 0.435536298604252 no 1433 0.439691011732553 1996 669426 SGTC_342 k048-0088 23.3 µM 0.151293892552712 0.435724067691227 no 1434 0.439871943432043 2023 6820570 SGTC_3303 9125618 40.5795 µM 0.150867283273551 0.435898688736856 no 1435 0.440040204600188 2087 22695467 SGTC_946 3434-1334 87.4 µM 0.150535168394578 0.436034639691959 no 1436 0.440171203242962 2096 4047976 SGTC_26 0302-0163 425.158 µM 0.147634496054008 0.43722234710329 no 1437 0.441315614744138 2046 3100915 SGTC_2675 theaflavin digallate 100 µM 0.147360202067285 0.437334688798425 no 1438 0.441423858340073 2106 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2421 5690543 90.72 µM 0.144884865130924 0.43834873194687 no 1439 0.442400888108865 2048 3397993 SGTC_544 k015-0020 52.4 µM 0.144599072958808 0.43846583537657 no 1440 0.442513714606592 2036 3008304 SGTC_306 1672-3436 11.6 µM 0.14445104147032 0.438526493442802 no 1441 0.442572157069547 2080 6797378 SGTC_2367 9070478 135.38 µM 0.14307692959976 0.439089624599093 no 1442 0.443114712489649 2060 572802 SGTC_2867 9039098 71.43 µM 0.141042995405553 0.439923386606884 no 1443 0.44391798819938 2113 6463460 SGTC_117 lucigenin 22.078 µM 0.139034153262359 0.440747124354961 no 1444 0.444711580367967 1934 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1813 st051246 8.6015 µM 0.138203770164695 0.441087703035349 no 1445 0.445039687766092 2154 5291959 SGTC_1990 st072050 59.8 µM 0.138014652662897 0.441165275008535 no 1446 0.445114418610154 1993 17233948 SGTC_846 0335-0850 148 µM 0.137330200795354 0.441446041440066 no 1447 0.445384899899069 2158 6819598 SGTC_262 fenpropimorph 62.5 µM 0.13718204293769 0.441506820597919 no 1448 0.445443452186401 2147 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2814 7977482 42.97 µM 0.133743327463217 0.442917877259407 no 1449 0.446802771278319 2133 6456762 SGTC_3072 9116419 49.47 µM 0.133613004369241 0.442971368932119 no 1450 0.446854300200484 2051 17170162 SGTC_1898 st060199 18.6 µM 0.133333809128664 0.44308596931328 no 1451 0.446964695241284 2108 688866 SGTC_2859 9028643 45.46 µM 0.133129346014718 0.443169897657127 no 1452 0.447045543473902 2121 17151580 SGTC_779 1360-0071 233 µM 0.133046448359673 0.443203926344941 no 1453 0.447078323259987 2190 7566 SGTC_2453 5731132 22.18 µM 0.132963203770853 0.443238097867246 no 1454 0.44711124059609 2160 1362040 SGTC_2933 9026794 32.47 µM 0.131980777798244 0.443641411049315 no 1455 0.447499747914826 2120 17586027 SGTC_2028 5153890 36.43 µM 0.131757292239155 0.443733166252566 no 1456 0.447588133911014 2091 2830968 YPR165W RHO1 SGTC_1726 st035556 14.5795 µM 0.131196956985577 0.443963233183827 no 1457 0.44780975156296 2158 5919439 SGTC_1412 3909-8563 178 µM 0.128163533575004 0.445209046351138 no 1458 0.449009779007569 2197 23767530 SGTC_682 0kpi-0099 17 µM 0.127830138914988 0.44534600325694 no 1459 0.449141699158272 2056 1714895 YML126C ERG13 SGTC_2269 7935389 174.42 µM 0.126583517629607 0.445858166887975 no 1460 0.449635021507857 2123 97605 SGTC_435 c-PAF 6.7 µM 0.125796734409075 0.446181456569727 no 1461 0.449946413401639 2186 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_710 3448-4187 58 µM 0.125580150711573 0.446270457226099 no 1462 0.450032137993632 2119 3946412 SGTC_446 go6976 132 µM 0.125024753747438 0.446498698649556 no 1463 0.450251976718918 2193 3501 A protein kinase C inhibitor. SGTC_1130 3454-2858 15.9 µM 0.124578824392162 0.446681966986984 no 1464 0.450428496732015 2000 715628 YIL048W NEO1 SGTC_1320 1313-0481 95.3 µM 0.124523905118249 0.446704538534434 no 1465 0.45045023706733 2173 6813365 YLR208W SEC13 SGTC_284 0988-0104 32.6 µM 0.123785439357572 0.447008061016706 no 1466 0.450742580424056 2167 4666532 SGTC_2229 7354935 190 µM 0.12377803196851 0.447011105742103 no 1467 0.450745512992179 2180 318112 SGTC_118 0083-0097 135.343 µM 0.122670971712016 0.447466185638774 no 1468 0.451183825717802 2129 5207356 SGTC_304 1310-0298 97 µM 0.122640761843005 0.447478604999205 no 1469 0.451195787394076 2112 1550234 SGTC_920 mycophenolic acid 780.421 nM 0.121258228193272 0.448047023304499 no 1470 0.451743252442709 2085 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_666 0272-0154 136 µM 0.121047781367853 0.448133556318131 no 1471 0.451826594678258 2104 6870312 SGTC_696 1560-0013 611 µM 0.120397051869636 0.448401143471143 no 1472 0.452084313341397 2160 1650269 SGTC_1913 st060213 96.1 µM 0.120003486671233 0.448562993226703 no 1473 0.452240192978225 2183 688959 SGTC_2224 6650123 117.647 µM 0.11915584324961 0.448911607155951 no 1474 0.452575944659577 2157 2908370 SGTC_1782 st039423 80.636 µM 0.118185705103783 0.449310648407424 no 1475 0.452960258123369 2005 2068169 SGTC_1255 0566-0045 221 µM 0.11686183131599 0.449855272318009 no 1476 0.453484772523403 2106 2788469 SGTC_2580 diallyl disulphide 81.36 µM 0.115084649006228 0.450586529610793 no 1477 0.454189013685833 2105 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1936 st074407 74.3 µM 0.114515528163431 0.450820741376741 no 1478 0.454414568839378 2146 809813 SGTC_651 3253-0966 34.4 µM 0.11419490829871 0.45095269444177 no 1479 0.454541644047857 2126 781462 SGTC_1650 st011916 45.8 µM 0.11408832126688 0.450996562187467 no 1480 0.454583890026276 2203 242528 SGTC_336 4111-0029 111 µM 0.113768754610741 0.451128088984961 no 1481 0.454710553972316 2096 3131175 SGTC_115 0527-0192 112.043 µM 0.113300489882446 0.451320826415282 no 1482 0.454896164436172 2071 4233931 SGTC_2142 5622915 118.518 µM 0.113043526183785 0.451426597371348 no 1483 0.454998023724732 2092 5322196 SGTC_1568 digitonin 820 nM 0.11297718490812 0.451453905213626 no 1484 0.455024321597667 2224 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2918 7977171 22.06 µM 0.112116041233866 0.451808395765957 no 1485 0.455365699276104 2182 2236483 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.111319538154629 0.452136311176418 no 1486 0.455681481245041 2123 6708760 SGTC_2452 5863136 48.41 µM 0.11078283964933 0.452357285072575 no 1487 0.455894276778073 2191 2184096 SGTC_3179 9107801 49.47 µM 0.110624433942232 0.45242250798908 no 1488 0.455957085460967 2172 4818259 SGTC_2773 thioridazine 9.09 µM 0.109991430924988 0.452683157249237 no 1489 0.456208085405723 2231 5452 An antipsychotic. SGTC_2704 st078022 71.1 µM 0.10906266861969 0.453065627069656 no 1490 0.456576392169899 2222 54697681 SGTC_2851 9015922 71.43 µM 0.107885744454325 0.453550353921694 no 1491 0.457043162695838 2176 2996893 SGTC_75 0159-0059 199.013 µM 0.107696957602705 0.453628113952188 no 1492 0.457118041479417 2194 5377270 SGTC_3077 9117319 49.47 µM 0.106631918656594 0.454066829528408 no 1493 0.457540497757775 2236 17154678 SGTC_1164 k060-0068 93.7 µM 0.105719940379658 0.454442540240487 no 1494 0.457902279438933 2230 5963676 SGTC_3158 9100007 49.47 µM 0.105352320069266 0.454594001544557 no 1495 0.458048124256656 2124 19297233 SGTC_3212 9128307 49.47 µM 0.10428119917698 0.455035345973518 no 1496 0.458473098721754 1923 27243542 SGTC_536 3852-0578 10.6 µM 0.103816633642712 0.45522678274927 no 1497 0.458657433030298 2203 2869208 SGTC_94 0334-0113 514.748 µM 0.101837537668515 0.456042438659459 no 1498 0.459442814887092 2208 6795178 SGTC_1760 st045453 10.4495 µM 0.100750810236773 0.456490396747425 no 1499 0.459874137902957 2227 3323419 YIL048W NEO1 SGTC_2949 9072542 2.23 µM 0.100554647750102 0.456571262465062 no 1500 0.459952000002598 2139 16457352 SGTC_1332 1480-0653 17.5 µM 0.099439015445298 0.457031203091145 no 1501 0.460394853205613 2248 5749438 SGTC_2628 lathosterol 100 µM 0.0990381784311519 0.45719646985908 no 1502 0.460553978547716 2169 6710616 SGTC_1378 2093-0007 380 nM 0.0976744879600033 0.45775878037527 no 1503 0.461095387163667 2141 3618014 SGTC_423 5-fluorouracil 457 µM 0.0973305714378234 0.457900605921616 no 1504 0.461231939376094 2144 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1005 4092-0690 4.4 µM 0.0952821434885145 0.458745454528215 no 1505 0.462045362775361 2138 1529343 SGTC_2832 7992762 51.95 µM 0.0944835806472084 0.459074862533101 no 1506 0.462362512419321 2030 2985177 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.0941055613702288 0.459230805692726 no 1507 0.462512651327403 2185 6708514 SGTC_3017 9080681 49.47 µM 0.0938520948233774 0.459335371002627 no 1508 0.462613324293445 2124 16451914 SGTC_2963 9082507 9 µM 0.0936597858118467 0.459414708206972 no 1509 0.462689708036815 2191 16459611 SGTC_2635 hydroquinidine 100 µM 0.0932595740906677 0.459579820983871 no 1510 0.462848673634861 2187 442912 An experimental heart treatment. SGTC_1042 0350-0096 82 µM 0.0928276700797591 0.459758016665857 no 1511 0.463020234185264 2059 3122515 SGTC_3336 9143619 71.43 µM 0.0918914457416421 0.460144313382038 no 1512 0.463392144007615 2250 45595730 SGTC_470 aa-861 153 µM 0.0916672256561644 0.460236834714839 no 1513 0.46348121892958 2113 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1357 1503-1303 39.5 µM 0.0913525539703209 0.460366683285657 no 1514 0.463606230245537 2225 292895 SGTC_2315 7733312 200 µM 0.0908929962287862 0.460556326354909 no 1515 0.463788807678558 2174 726316 SGTC_2707 st078556 66.6 µM 0.0902485625465464 0.460822276225431 no 1516 0.464044847205757 2264 17250899 SGTC_41 0478-0632 82.643 µM 0.0898044322280894 0.46100557356409 no 1517 0.464221313008058 2260 3750424 SGTC_1698 5-fluorocytosine 1.055 µM 0.0893482919378188 0.461193836170387 no 1518 0.464402558045218 2256 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2302 7771753 200 µM 0.0887408099900289 0.461444575457744 no 1519 0.464643949387816 2150 2203047 SGTC_2286 7945697 125 µM 0.088527612634917 0.461532576695251 no 1520 0.464728669391074 2165 1245733 SGTC_2232 chlorophetanol 41.5365 µM 0.087442898763818 0.461980341924342 no 1521 0.465159735831983 2252 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.0866538615372737 0.462306083413791 no 1522 0.465473325779381 2161 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2888 9058547 12.99 µM 0.0862167714783704 0.462486539999627 no 1523 0.465647049319408 2215 16476514 SGTC_2399 5884133 200 µM 0.0860294082009419 0.462563896990571 no 1524 0.465721519759132 2167 722445 SGTC_637 1181-0519 7.26 µM 0.0855081083018074 0.462779134396236 no 1525 0.465928724794881 2234 6252091 YGR060W ERG25 SGTC_2214 7179297 48.276 µM 0.0837232827287657 0.463516145952945 no 1526 0.466638222596643 2263 769744 SGTC_361 000s-0510 1.45 µM 0.0827385305553496 0.463922835388551 no 1527 0.467029723469004 2179 660 SGTC_729 4092-0585 94.1 µM 0.0813177242025342 0.464509675678337 no 1528 0.467594639396923 2192 2169061 SGTC_953 1188-0045 9.7 µM 0.0811763962821481 0.46456805305399 no 1529 0.467650835296346 2194 6144426 SGTC_3026 9090633 49.47 µM 0.0809055713925211 0.464679923003814 no 1530 0.467758524581522 2223 25236842 SGTC_1186 1319-0216 26 µM 0.0808701889501618 0.464694538676527 no 1531 0.467772594031249 2269 4565136 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.0804817290560508 0.464855005647612 no 1532 0.467927063596333 2271 5024745 SGTC_3269 9137823 49.47 µM 0.080168133220057 0.46498455156711 no 1533 0.468051767284148 2128 17682936 SGTC_630 4356-0227 183 µM 0.0791745642021955 0.46539501772173 no 1534 0.468446887946679 2259 779312 SGTC_125 0133-0007 11.75 µM 0.0787308882674461 0.465578322346899 no 1535 0.468623338222168 2272 26541 SGTC_2977 9011197 71.43 µM 0.0783826157867805 0.465722216172435 no 1536 0.468761850787224 2253 2704722 SGTC_2521 angolensin 13.4 µM 0.0775241483895499 0.466076923525068 no 1537 0.46910329072114 2201 821428 A flavenoid. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.0775166890490644 0.466080005744216 no 1538 0.469106257639315 2237 688667 SGTC_365 0121-0052 13.6 µM 0.0774037029935659 0.466126692128821 no 1539 0.469151197529974 2238 3101739 SGTC_1862 st057513 3.81 µM 0.0768817750495097 0.466342361319736 no 1540 0.469358798016439 2248 5393163 SGTC_2995 9067767 71.4286 µM 0.0761461613693103 0.46664634573073 no 1541 0.469651407629098 2190 11673567 SGTC_1934 st074720 32.6 µM 0.0757885245167398 0.466794142338944 no 1542 0.469793672987688 2258 17250992 SGTC_543 3844-1095 191 µM 0.0753959805618843 0.46695636988762 no 1543 0.46994982857799 2234 4230703 SGTC_3045 9092950 49.47 µM 0.0753804499102923 0.466962788389009 no 1544 0.469956006829898 2283 44120432 SGTC_502 l-744,832 89.3 µM 0.074418457929818 0.467360376725366 no 1545 0.470338711110898 2288 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_1214 0358-0031 63.7 µM 0.0735476095217728 0.467720323797762 no 1546 0.470685179854623 2268 4301366 SGTC_156 3474-0145 5.642 µM 0.0724068954340189 0.468191854120049 no 1547 0.471139048718953 2288 2265471 SGTC_2980 9014342 25.29 µM 0.0710472855503164 0.468753926361908 no 1548 0.471680061059806 2185 2996599 SGTC_387 norethindrone acetate 66.7 µM 0.0703106167321255 0.469058496495066 no 1549 0.471973216245758 2200 541197 SGTC_2592 piperlongumine 83.33 µM 0.0698488204581752 0.469249431905289 no 1550 0.472156994465444 2191 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_766 1391-0721 126 µM 0.0674507116633494 0.470241072534705 no 1551 0.473111449503339 2277 1020919 YIL115C NUP159 SGTC_3219 9131112 49.47 µM 0.0662254849141673 0.470747786995241 no 1552 0.473599153640682 2301 17612988 YMR079W SEC14 SGTC_616 4092-0450 108 µM 0.0661747439027914 0.470768772876089 no 1553 0.473619352067592 2224 787165 SGTC_2925 9010536 32.5 µM 0.065508745080612 0.471044229598138 no 1554 0.47388447186321 2213 2994177 SGTC_110 0850-0284 111.64 µM 0.0654811564650868 0.471055640533067 no 1555 0.473895454547523 2308 3906265 SGTC_2938 9059746 27.26 µM 0.0653176622269137 0.471123263917699 no 1556 0.473960539974845 2244 6471769 SGTC_1629 st005085 44.9 µM 0.0644521982990206 0.471481245096316 no 1557 0.474305084078545 2236 24207091 SGTC_2701 st077767 14.721 µM 0.0644283543712893 0.47149110796929 no 1558 0.474314576699684 2248 5721188 SGTC_2440 5628896 157.78 µM 0.0642971765753471 0.47154536905433 no 1559 0.474366800785744 2263 5522048 SGTC_314 1671-0008 2.74 µM 0.0637010831477227 0.471791946966134 no 1560 0.474604121136714 2230 3913060 SGTC_552 k242-0005 476 µM 0.0633133380465441 0.471952346051717 no 1561 0.474758497423941 2231 4088318 SGTC_672 1441-0018 53.7 µM 0.0631922189242393 0.47200245051061 no 1562 0.474806720398224 2265 251141 SGTC_1836 st055642 81 µM 0.0629783996147928 0.472090904187717 no 1563 0.474891852390022 2252 8571 SGTC_799 1310-0557 151 µM 0.0623465371566151 0.472352303752075 no 1564 0.475143434621128 2211 5354492 SGTC_2107 5363541 170.161 µM 0.0622371923427995 0.472397540578622 no 1565 0.475186972339296 2301 244052 SGTC_2429 5902844 64.44 µM 0.061430043650445 0.472731475443008 no 1566 0.475508363080801 2288 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_841 0251-0215 91.2 µM 0.0608384424268112 0.472976245845143 no 1567 0.475743937190216 2232 3888614 SGTC_1001 4048-4355 44.4 µM 0.0606958772455617 0.473035232608706 no 1568 0.47580070755538 2280 21824233 SGTC_2424 5537928 59.2 µM 0.0591767739719809 0.473663802522671 no 1569 0.476405654450539 2251 5382802 SGTC_901 1112-0062 60.1 µM 0.0583289316596211 0.474014648739071 no 1570 0.476743311304284 2312 1908457 SGTC_1673 st016611 27.3 µM 0.0572162469985616 0.474475120092057 no 1571 0.477186468064098 2268 5226799 SGTC_3236 9132701 49.47 µM 0.0553240184753937 0.475258274406388 no 1572 0.477940163745066 2233 24282524 SGTC_1627 st003713 25.6 µM 0.0550401237129618 0.475375780908148 no 1573 0.478053249061625 2253 16195070 YER133W GLC7 SGTC_2889 9059656 51.95 µM 0.0544580959904484 0.475616693910502 no 1574 0.478285096786992 2265 3949838 SGTC_1416 3966-0321 25.3 µM 0.0544503869684929 0.47561988489004 no 1575 0.4782881676854 2281 582530 YLR208W SEC13 SGTC_2695 st077686 51.995 µM 0.053459579729519 0.476030020627646 no 1576 0.478682867636855 2263 2876092 SGTC_3258 9138477 49.47 µM 0.0524098995879327 0.476464553968995 no 1577 0.479101043114481 2323 4970355 SGTC_213 1246-0773 967 nM 0.0517339260108486 0.47674439982995 no 1578 0.479370352188446 2244 6251622 SGTC_3027 9089541 49.47 µM 0.0490879983083699 0.477839894741721 no 1579 0.480424583920166 2262 9943819 SGTC_2419 paclitaxel 166.5 µM 0.049082851369858 0.477842025897402 no 1580 0.480426634779416 2222 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1621 st003705 32.4 µM 0.0490099725038656 0.477872202391396 no 1581 0.480455674291381 2314 24207032 SGTC_3178 9107506 49.47 µM 0.0490080733804582 0.477872988751186 no 1582 0.480456431022668 2294 8897194 SGTC_3296 9122258 64.045 µM 0.0483084813973352 0.47816267086722 no 1583 0.480735197634864 2279 4730474 SGTC_1156 4092-0367 4.88 µM 0.0478727425326085 0.478343104384865 no 1584 0.480908831391714 2270 1357585 SGTC_2216 7189485 200 µM 0.0465683424492167 0.478883265045562 no 1585 0.481428631855315 2312 731273 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0463669702812924 0.47896665806693 no 1586 0.481508881041525 2285 688761 SGTC_1600 coumarin 106 71.1 µM 0.0442047280306103 0.479862151473244 no 1587 0.482370606657958 2289 100336 A hepatotoxic, DNA x-linker. SGTC_641 4092-0595 30 µM 0.0438277174967929 0.480018301055683 no 1588 0.482520866469867 2301 786260 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.0417722670639978 0.480869677331589 no 1589 0.483340121692974 2335 65057 A dermal irritant. YDR527W RBA50 SGTC_2022 5136654 200 µM 0.0414738612930169 0.480993285612161 no 1590 0.483459065292981 2298 1713771 SGTC_957 1187-1561 14.1 µM 0.0408531311682332 0.481250415781196 no 1591 0.483706491068432 2335 1538454 SGTC_853 0419-0306 21 µM 0.0408155179233333 0.481265996878187 no 1592 0.483721484076927 2287 762713 SGTC_511 blebbistatin 171 µM 0.0406770197151064 0.481323369308922 no 1593 0.483776691019981 2334 3476986 A myosin inhibitor. SGTC_2484 5809818 12.04 µM 0.0401029024664917 0.481561199617467 no 1594 0.484005543915603 2304 2870548 SGTC_2824 7998404 51.95 µM 0.0397394270226678 0.481711774135119 no 1595 0.484150434135494 2300 837851 SGTC_2418 pentamidine 31.67 µM 0.0394758924595434 0.481820948451789 no 1596 0.484255486780896 2344 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1838 st055369 84.5 µM 0.0392871006777896 0.481899159956693 no 1597 0.484330745422686 2328 676036 SGTC_533 1222-0222 6.71 µM 0.0385594750447721 0.4822006027445 no 1598 0.484620806238056 2321 3982874 SGTC_1173 0443-0020 122 µM 0.0372272890551265 0.482752530740123 no 1599 0.485151890084653 2306 5331295 SGTC_3011 9081274 71.4286 µM 0.0368616790980215 0.482904009687423 no 1600 0.48529764730868 2300 6625322 SGTC_1558 st069300 45.6 µM 0.036377083049561 0.483104790566154 no 1601 0.485490843579923 2346 24208000 SGTC_403 arphamenine a 50 µM 0.0356970277265498 0.483386562573234 no 1602 0.485761970286919 2346 5487158 An arginine aminopeptidase inhibitor. SGTC_1503 4585-0012 61.3 µM 0.0355691895491203 0.483439531576753 no 1603 0.485812937973332 2323 2922052 SGTC_256 clotrimazole 625 nM 0.0347966020017294 0.483759654910142 no 1604 0.486120965101075 2332 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2971 9092186 9.93 µM 0.0346738383895929 0.483810523249522 no 1605 0.486169911159933 2305 25236400 SGTC_2342 7990637 118.86 µM 0.0344827073173412 0.483889720858897 no 1606 0.48624611585468 2311 2033102 YER133W GLC7 SGTC_1192 1488-0095 21.4 µM 0.0339430299890642 0.484113346497334 no 1607 0.486461289986381 2286 915875 SGTC_560 2332-1943 155 µM 0.0335804395055726 0.484263595620455 no 1608 0.486605860241897 2354 21177716 SGTC_2122 5258151 111.688 µM 0.0330580815197774 0.484480052629711 no 1609 0.4868141352828 2307 2173356 SGTC_2017 5132927 60.65 µM 0.0327223827491961 0.484619163387082 no 1610 0.486947987297282 2334 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2390 9097792 176.6 µM 0.032667414331262 0.484641942017652 no 1611 0.486969904805718 2316 4497149 SGTC_2720 fluspirilene 36.88 µM 0.032505998816179 0.484708832068929 no 1612 0.487034266097837 2340 3396 An atypical antipsychotic. SGTC_2789 5281112 71.43 µM 0.0320814601945976 0.484884761507537 no 1613 0.487203544210562 2327 765948 SGTC_1102 cgs 12066b 26.1 µM 0.0316364592815204 0.485069173708199 no 1614 0.487380983815282 2290 6438352 A 5-HT1B full agonist. SGTC_2265 7929201 200 µM 0.0301775481540477 0.485673781197168 no 1615 0.487962727176346 2355 1265108 SGTC_491 tetrandrine 80.3 µM 0.0295347549069861 0.485940180549784 no 1616 0.488219050308372 2336 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2820 7989630 71.43 µM 0.0289684527351362 0.486174884130044 no 1617 0.488444875550121 2358 2984098 SGTC_3078 9116413 49.47 µM 0.0264180529390963 0.487231953901657 no 1618 0.489461947505854 2353 17177322 SGTC_2257 7960413 200 µM 0.0264159424725799 0.487232828669494 no 1619 0.489462789166447 2299 2974689 YIL048W NEO1 SGTC_1728 st035614 33.7865 µM 0.0260997705691269 0.487363879538829 no 1620 0.48958888003034 2250 15945546 SGTC_2816 7982706 58.44 µM 0.0256240064385948 0.487561082749545 no 1621 0.489778618992863 2337 2981853 SGTC_2596 sinensetin 100 µM 0.0252544033416881 0.487714284541372 no 1622 0.489926021590602 2329 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_1439 4092-1168 46 µM 0.0249300995085285 0.48784871112208 no 1623 0.490055359377471 2347 2886240 SGTC_505 gw-5074 63.9 µM 0.0244577059878798 0.488044524550541 no 1624 0.490243759673138 2347 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_367 0335-0881 7.1 µM 0.0230344757144444 0.488634489752444 no 1625 0.490811386297752 2347 23828853 SGTC_867 0518-0118 155 µM 0.0229981885181546 0.48864953205025 no 1626 0.490825858960623 2365 6848158 SGTC_2531 methyl deoxycholate 70.07 µM 0.0223787727301719 0.488906303788418 no 1627 0.491072906509483 2345 16667744 Haematoxylin. SGTC_2283 7944793 200 µM 0.0211186583676839 0.489428683879664 no 1628 0.491575500494376 2354 2970533 SGTC_2134 5324836 1.464 µM 0.0208982097319334 0.489520072695086 no 1629 0.491663427370062 2349 699272 SGTC_2952 9073731 13.78 µM 0.0201665178060365 0.489823405585643 no 1630 0.491955268685605 2358 16457353 SGTC_783 0848-0141 92.7 µM 0.0200493219951576 0.489871991262626 no 1631 0.492002013598519 2359 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2417 cerulenin 830 nM 0.0198467852059071 0.489955956964279 no 1632 0.492082798012288 2369 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1096 rimcazole 32.2 µM 0.017624974159771 0.490877081855772 no 1633 0.492969016635679 2371 18528119 A dopamine reuptake inhibitor. SGTC_3034 9090421 49.47 µM 0.0171589048037484 0.491070312583967 no 1634 0.493154923287107 2365 17173761 SGTC_1388 3346-4487 254 µM 0.0170555278861911 0.491113172578708 no 1635 0.493196158675969 2350 3345614 SGTC_2545 solidagenone 89.61 µM 0.01699499845965 0.491138268082534 no 1636 0.493220302923946 2374 6708572 An anti ulcer agent SGTC_2388 9080168 200 µM 0.016850300885346 0.491198259847374 no 1637 0.493278020639079 2374 15943073 SGTC_1271 0832-2808 169 µM 0.0166124157901749 0.491296887687405 no 1638 0.493372909778712 2376 3663794 SGTC_2145 5634607 200 µM 0.0162962217016329 0.491427983482444 no 1639 0.493499035893781 2375 308662 SGTC_727 3032-0951 202 µM 0.0160883830363073 0.491514155032787 no 1640 0.493581940655593 2356 3652836 SGTC_3257 9139206 32.98 µM 0.015815877334751 0.491627138645938 no 1641 0.493690640869882 2373 4910041 SGTC_1997 st073024 93.8 µM 0.0158042190325961 0.49163197231068 no 1642 0.49369529127829 2382 686268 SGTC_1841 st054148 70 µM 0.0140650564889768 0.492353062264503 no 1643 0.494389039289734 2346 675442 SGTC_972 1319-0219 195 µM 0.0135648246304248 0.492560472662972 no 1644 0.494588583883325 2364 23903702 SGTC_1797 st048695 56.8 µM 0.0134157368427494 0.49262228910431 no 1645 0.494648055893433 2382 592262 YIL048W NEO1 SGTC_280 3448-3607 3.04 µM 0.0130795206128639 0.492761695475486 no 1646 0.494782174992814 2378 626179 SGTC_2405 ticlatone 3.52 µM 0.0127060269122674 0.492916559354965 no 1647 0.494931165037233 2387 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2101 5377231 179.231 µM 0.0124473823374605 0.493023803296161 no 1648 0.495034341133248 2371 2844213 SGTC_1548 st061468 90.8 µM 0.0118941291223274 0.493253204939751 no 1649 0.495255040883284 2382 390799 SGTC_1002 4049-0206 172 µM 0.011718705074107 0.493325943468237 no 1650 0.495325020075607 2384 4662749 SGTC_2722 naftopidil 47.16 µM 0.0112174661924215 0.493533780376131 no 1651 0.49552497230701 2378 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_704 1310-0270 142 µM 0.011097525717939 0.493583513526885 no 1652 0.495572818655102 2379 5718033 SGTC_1475 4092-1048 11.7 µM 0.0107929339570774 0.49370981252291 no 1653 0.495694325907917 2373 2881759 SGTC_1947 st076332 61.6 µM 0.0105649108030781 0.493804362753875 no 1654 0.495785288797937 2386 24208416 SGTC_2756 carbadox 75.1 µM 0.0100396827383437 0.494022150877194 no 1655 0.495994813357922 2389 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_134 0269-0018 6.916 µM 0.00966236625037704 0.494178607919278 no 1656 0.496145333553553 2375 4378915 SGTC_913 3487-1245 167 µM 0.00906272490501537 0.49442725542264 no 1657 0.496384545351156 2380 4016153 SGTC_3094 9117742 49.47 µM 0.00880686106317949 0.494533352683124 no 1658 0.496486616181146 2396 17149698 SGTC_2313 7726885 200 µM 0.00758783682727542 0.495038842073499 no 1659 0.49697292012033 2388 726423 SGTC_951 1171-0579 82.7 µM 0.00648767541392361 0.49549504980913 no 1660 0.497411810132 2386 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2445 5742597 35.57 µM 0.00648084019981994 0.49549788421002 no 1661 0.497414536930576 2384 1774255 SGTC_2091 4-phenylthiadiazole 200 µM 0.00645689291474434 0.495507814581965 no 1662 0.497424090315205 2393 270010 SGTC_831 k061-1017 217 µM 0.00533043433956523 0.49597493331204 no 1663 0.497873474439398 2394 1240153 SGTC_2448 5185112 27.17 µM 0.00405098241104156 0.49650550183369 no 1664 0.498383896259241 2392 5718189 SGTC_249 wiskostatin 11.211 µM 0.00394551141906173 0.496549239278036 no 1665 0.49842597276096 2393 2775510 A n-wasp and actin depolymerizer. SGTC_2344 7990960 76.95 µM 0.0032804267973692 0.496825042127657 no 1666 0.498691301399963 2396 140813 SGTC_3187 9109394 49.47 µM 0.00229114524297104 0.497235288438704 no 1667 0.499085966091718 2399 17098090 SGTC_2178 5812956 200 µM 0.00158554769320939 0.497527895313699 no 1668 0.499367458252617 2404 5403383 SGTC_889 0919-1524 82.7 µM 0.00149478515681718 0.4975655340677 no 1669 0.499403667222902 2398 3905452 SGTC_2318 6029776 164 µM 0.00138398789207711 0.497611481149176 no 1670 0.499447868890548 2399 818325 SGTC_2651 TUB2.036 5 µM 0.000971600623943831 0.49778249639728 no 1671 0.499612387492429 2398 15992207 YFL037W TUB2 SGTC_225 nsc-122657 1.016 µM -0.000327409583989908 0.498321192928038 no 1672 0.499869382476271 2408 275685 SGTC_1327 1436-0082 2.18 µM -0.00067720584512177 0.498466253193038 no 1673 0.499729833976496 2407 15992205 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.000823182676827493 0.498526789744189 no 1674 0.499671597662809 2408 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3052 9092717 49.47 µM -0.00228455673837306 0.499132822796363 no 1675 0.499088594517888 2416 25237534 SGTC_3131 9127911 49.47 µM -0.00248062804085065 0.499214133913343 no 1676 0.499010373607502 2413 45595681 SGTC_1859 st055998 20 µM -0.00277044720793803 0.499334322494898 no 1677 0.498894752886998 2411 676301 SGTC_2409 alverine citrate 63.97 µM -0.00416472849494573 0.499912534351892 no 1678 0.498338518520031 2434 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_691 1548-0686 185 µM -0.0045865519180105 0.499912534351892 no 1679 0.498170236933941 2419 46495133 SGTC_97 0535-0701 19.132 µM -0.00551168991234953 0.49952887726914 no 1680 0.497801164990475 2418 2832013 YGL099W LSG1 SGTC_861 0443-0273 110 µM -0.00580859339992792 0.499405750711904 no 1681 0.497682719533862 2452 6149169 SGTC_1011 4112-3381 17.4 µM -0.00641972976709967 0.499152311250011 no 1682 0.497438915958794 2471 2877139 SGTC_1983 st071813 46.9 µM -0.00647521551857734 0.499129301214383 no 1683 0.497416780806655 2434 11838595 SGTC_2118 5526350 200 µM -0.00663309790730678 0.499063827135012 no 1684 0.497353796199354 2434 743594 SGTC_527 4476-4215 268 µM -0.00718985416010128 0.498832939638731 no 1685 0.497131687898059 2429 4418754 SGTC_3250 9135583 49.47 µM -0.00720831096239721 0.498825285586602 no 1686 0.497124324890065 2424 7699353 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.00794916443933059 0.498518053386155 no 1687 0.496828775609186 2423 6312947 SGTC_2003 4023581 200 µM -0.00827038764188451 0.498384842272246 no 1688 0.496700630306822 2428 16641307 SGTC_1954 st077032 68.9 µM -0.00839687949596899 0.498332386207308 no 1689 0.496650169110416 2437 698907 SGTC_1387 3342-1166 1.8 µM -0.00898305604936967 0.498089299676962 no 1690 0.496416327332343 2441 3418228 SGTC_1039 k821-0043 94 µM -0.0113718061491163 0.497098696915262 no 1691 0.495463403500045 2409 15992768 SGTC_1009 4106-0057 9.87 µM -0.0116540425493295 0.496981655949728 no 1692 0.495350814929215 2420 2928005 SGTC_3189 9110682 49.47 µM -0.0117298425697014 0.496950222388386 no 1693 0.495320577163086 2429 17122418 SGTC_2151 5563267 85.4165 µM -0.0117386167194337 0.496946583831561 no 1694 0.495317077024762 2433 5310824 SGTC_312 4092-0653 6.84 µM -0.0118600177965176 0.496896239980464 no 1695 0.495268648373586 2463 1148278 SGTC_2010 4012422 159 µM -0.0119212303264615 0.496870855755733 no 1696 0.495244229833598 2442 952393 SGTC_1136 pergolide 1.05886 µM -0.0128636050375821 0.496480064037303 no 1697 0.494868305598089 2432 47811 A dopamine receptor agonist. SGTC_2750 bromebric acid 70.15 µM -0.0131049689394478 0.496379973791963 no 1698 0.494772023449434 2449 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_618 k072-0232 33.2 µM -0.0137996108629473 0.496091916763676 no 1699 0.494494926495417 2437 5872756 YGL099W LSG1 SGTC_1559 coumarin 343 70.1 µM -0.0141064130675772 0.495964691377617 no 1700 0.494372542038633 2444 108770 A hepatotoxic, DNA x-linker. SGTC_349 k015-0014 24 µM -0.014435369147684 0.49582827963199 no 1701 0.494241320913293 2432 2196908 SGTC_2366 9070441 60.58 µM -0.0150145247657192 0.495588116155912 no 1702 0.49401029630076 2440 6837235 SGTC_1846 st056244 14.8 µM -0.0154762488103462 0.495396650188762 no 1703 0.493826116464066 2461 5393182 SGTC_1449 4112-4002 201 µM -0.0155843353057956 0.495351829444303 no 1704 0.493783001390887 2449 2059539 SGTC_598 3937-0236 20.2 µM -0.0157074463444427 0.495300778472105 no 1705 0.493733893203478 2438 1379313 SGTC_3044 9093193 49.47 µM -0.0158449493437045 0.495243759616085 no 1706 0.493679044269491 2455 25236277 SGTC_187 1488-2104 32.728 µM -0.0181011494776092 0.494308187842479 no 1707 0.492779080475989 2469 2852859 SGTC_1024 4507-0395 26 µM -0.0186716704509961 0.494071616369825 no 1708 0.492551514009754 2524 4201836 SGTC_612 0302-0167 22.4 µM -0.0189489140629439 0.49395665564781 no 1709 0.492440929376982 2452 235821 SGTC_2064 5220758 200 µM -0.0194152083603315 0.493763305065132 no 1710 0.492254939089176 2463 788518 SGTC_2907 7721985 69.9 µM -0.0206491821028491 0.493251640669713 no 1711 0.491762753585786 2455 3267881 SGTC_1148 3909-7663 27.7 µM -0.0234661377203729 0.492083639403997 no 1712 0.490639224613672 2513 4084526 SGTC_1183 1254-0324 198 µM -0.0242942428635737 0.491740292583584 no 1713 0.490308952653313 2471 5799357 SGTC_1753 st043925 64 µM -0.0248370906864497 0.491515221723037 no 1714 0.490092453043183 2445 670181 SGTC_2865 9030313 51.95 µM -0.0248791633262141 0.491497778041574 no 1715 0.490075673673343 2441 42562754 SGTC_2050 5263056 171 µM -0.0251798551736298 0.491373109068237 no 1716 0.489955752552245 2458 763468 YGL055W OLE1 SGTC_1239 0337-0584 35.4 µM -0.0252818796704347 0.491330809178868 no 1717 0.489915063620131 2465 914301 YML130C ERO1 SGTC_264 promethazine 12.5 mM -0.0258920884892157 0.491077815466576 no 1718 0.489671705201878 2448 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2728 chlorpromazine 9.18 µM -0.0260726229873809 0.491002966211005 no 1719 0.489599706664176 2457 2726 A thorazine and dopamine antagonist. SGTC_816 0325-0417 81.3 µM -0.0264038105551086 0.49086565730825 no 1720 0.489467627413681 2470 68101 SGTC_2605 digitonin 300 nM -0.0266606185227024 0.490759186603432 no 1721 0.489365211912216 2455 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_287 k060-0039 29.6 µM -0.0268070214796566 0.490698489302599 no 1722 0.489306826450453 2463 5861974 SGTC_2747 doxorubicin 7.63 µM -0.0268773411011513 0.490669335519703 no 1723 0.489278783084783 2449 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1765 st044815 90.4 µM -0.0269102018014228 0.4906557118326 no 1724 0.489265678302119 2486 645695 SGTC_833 3852-0053 558 µM -0.0277401420726631 0.490311631326043 no 1725 0.488934703633881 2478 3123681 SGTC_880 0833-0487 87.2 µM -0.028060954340402 0.490178629398603 no 1726 0.488806767861648 2453 76075 SGTC_2477 5967686 25.23 µM -0.0291410261168714 0.489730862776892 no 1727 0.488376057785109 2462 776118 SGTC_2625 euphol 100 µM -0.0292387221382726 0.489690361452673 no 1728 0.488337099312355 2473 6708538 A triterpene alcohol. SGTC_1350 1495-0454 146 µM -0.0294744283351745 0.489592646416478 no 1729 0.488243106655439 2475 1069057 SGTC_3278 9139605 49.47 µM -0.0295589052798399 0.489557625564054 no 1730 0.488209419908213 2589 7958859 SGTC_928 2764-0428 58.7 µM -0.0297783132739052 0.489466667928405 no 1731 0.488121927298025 2550 662578 SGTC_1243 0416-0003 5.65 µM -0.0299359510723838 0.489401318042859 no 1732 0.488059066939913 2480 2141977 SGTC_99 0109-0120 622.8 µM -0.0299994323573107 0.489375001498908 no 1733 0.488033752940676 2462 759414 SGTC_1195 1502-0147 41.1 µM -0.0320955194929855 0.488506082784907 no 1734 0.487197938248894 2453 817940 SGTC_2037 5169046 200 µM -0.0323032336287929 0.488419979201328 no 1735 0.487115115244602 2515 5718022 SGTC_2506 ethyl hematommate 54.16 µM -0.0364790023711317 0.486689120850591 no 1736 0.485450210622337 2512 3940691 An allergen. SGTC_1826 st055655 41.6 µM -0.0365114591809144 0.486675668425497 no 1737 0.485437270848752 2506 676168 SGTC_1754 st042065 16.137 µM -0.0369827783900519 0.486480321726651 no 1738 0.485249368600208 2504 1126236 YIL048W NEO1 SGTC_690 glyoxal 20.3 µM -0.0374342405632077 0.486293208173758 no 1739 0.485069385886615 2482 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_3003 9075612 71.4286 µM -0.0382230607989274 0.485966280061364 no 1740 0.484754917235003 2518 6501993 SGTC_1266 0828-0227 32.9 µM -0.0387865146615117 0.485732761251679 no 1741 0.484530298243022 2507 3913820 SGTC_2764 methyldopa 94.69 µM -0.0388075448438911 0.485724045560123 no 1742 0.484521914725956 2494 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1689 st020265 53.493 µM -0.0389008893802597 0.485685360186858 no 1743 0.484484703742155 2482 5758320 YPR016C TIF6 SGTC_3218 9131285 49.47 µM -0.0390691518585581 0.485615626432263 no 1744 0.484417627716948 2495 17156417 SGTC_3151 9099821 49.47 µM -0.0392463912055205 0.485542172830482 no 1745 0.484346973636604 2526 17174189 SGTC_3345 9148410 3.559 µM -0.0397018241352029 0.485353429248313 no 1746 0.484165423687784 2489 4903596 SGTC_3188 9110789 49.47 µM -0.0401208867330521 0.485179761401715 no 1747 0.483998375000873 2506 849217 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.0403698241478114 0.485076598131756 no 1748 0.483899143735633 2525 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_200 k038-0079 37.545 µM -0.0411448132853689 0.484755437835519 no 1749 0.48359022449811 2511 3436683 SGTC_2165 5727197 32.143 µM -0.0412768092894787 0.484700738854119 no 1750 0.483537610408309 2709 1361712 SGTC_1843 st055809 45.5 µM -0.0416381688805016 0.484550993360994 no 1751 0.483393572623561 2575 16413835 SGTC_621 3584-0052 32.1 µM -0.042062835151779 0.48437501670254 no 1752 0.483224303593435 2479 2273927 SGTC_1458 k015-0034 6.33 µM -0.0422834181584799 0.484283610923513 no 1753 0.483136381928211 2507 3598957 SGTC_389 tpck 16.7 µM -0.0424093063516701 0.48423144540562 no 1754 0.483086204814713 2497 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1714 st033236 13.627 µM -0.0435544046631333 0.483756952358182 no 1755 0.482629798494367 2520 2916566 SGTC_2063 5246145 200 µM -0.0437244876349184 0.483686477221921 no 1756 0.48256200978502 2530 711240 SGTC_1525 8-methoxypsoralen 92.5 µM -0.0441213195647069 0.483522048964824 no 1757 0.482403849387873 2497 4114 Related to psoralen; DNA damaging agent. SGTC_1578 josamycin 24.2 µM -0.0444686218406234 0.483378145736579 no 1758 0.482265431684096 2490 5282165 A P450 substrate. SGTC_477 mead ethanolamide 10 µM -0.0466170941867001 0.482487984158455 no 1759 0.481409203825415 2476 16061185 SGTC_639 0833-0042 114 µM -0.0471728911210123 0.482257718720494 no 1760 0.481187716606531 2512 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_540 1187-0821 17.3 µM -0.0478013362324079 0.48199736243724 no 1761 0.480937285808021 2496 847520 SGTC_1984 st072354 53.1 µM -0.0486808372586025 0.481633010010469 no 1762 0.480586823709774 2507 5762938 SGTC_708 3448-5400 146 µM -0.0489713190913335 0.481512674949373 no 1763 0.480471076277801 2486 3462195 SGTC_3216 9129716 49.47 µM -0.0491346563057721 0.481445011581996 no 1764 0.480405992506334 2508 8056934 SGTC_1931 st074438 57.1 µM -0.0514960305206382 0.480466859621224 no 1765 0.479465132421167 2482 2787313 SGTC_1968 st069590 43.6 µM -0.0515413320473839 0.480448095502232 no 1766 0.479447083694918 2525 6384066 SGTC_2274 7947094 46.08 µM -0.0529341644031036 0.479871198716705 no 1767 0.478892181643689 2493 2971028 SGTC_227 fluconazole 33.516 µM -0.0537097927239731 0.479549959670517 no 1768 0.478583190299989 2504 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1103 duloxetine 36.1 µM -0.0539603473463606 0.479446191239113 no 1769 0.478483378211113 2610 60835 A selective serotonin reuptake inhibitor. SGTC_2790 5423970 71.43 µM -0.0543642781068207 0.479278904260599 no 1770 0.478322469344276 2561 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_814 3342-0569 96 µM -0.0547537169677647 0.479117622523891 no 1771 0.478167336780227 2502 4346283 SGTC_1437 4092-1038 11.6 µM -0.0548314462780438 0.479085432210252 no 1772 0.47813637378581 2502 3977136 SGTC_642 0335-0876 158 µM -0.0554415518563932 0.478832771787774 no 1773 0.477893346565204 2518 6812350 SGTC_754 3474-0146 171 µM -0.0567158662538693 0.478305072953777 no 1774 0.477385767458505 2494 24762078 SGTC_23 0213-0011 39.996 µM -0.0568447070124411 0.478251721567214 no 1775 0.477334450222627 2538 627608 SGTC_2927 9011802 47.9 µM -0.0581180541478827 0.477724465161278 no 1776 0.47682729678449 2557 43912568 SGTC_2420 aureobasidin a 50 nM -0.0581846661573915 0.477696884110123 no 1777 0.476800767331205 2691 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2301 7769476 200 µM -0.0590846012539289 0.477324271797982 no 1778 0.476442361816212 2546 977820 SGTC_2057 5236571 38.335 µM -0.0595419703204404 0.477134908668005 no 1779 0.476260218637227 2524 54684039 YBR257W POP4 SGTC_2438 5259590 200 µM -0.0596671717786302 0.477083072785576 no 1780 0.47621035912879 2572 1201127 SGTC_897 1000-0139 31.4 µM -0.0601976612027559 0.476863443973909 no 1781 0.475999104214259 2504 6151020 SGTC_1292 0kpi-0043 232 µM -0.0605232175043747 0.47672866334183 no 1782 0.47586946242403 2542 3333905 SGTC_317 4495-0002 170 µM -0.0608205881032747 0.476605553944683 no 1783 0.475751046868864 2545 15991618 SGTC_1508 1080-0625 72.9 µM -0.0612678206933965 0.476420406914638 no 1784 0.475572959003137 2484 767111 SGTC_756 0508-1999 28.3 µM -0.0616368767081944 0.476267627549025 no 1785 0.475426004696435 2524 6753853 SGTC_3066 9117245 49.47 µM -0.0617722708376121 0.476211578857263 no 1786 0.475372092984681 2544 17176980 SGTC_1133 3473-0247 50 µM -0.0628185098118958 0.475778486477628 no 1787 0.474955513140077 2602 711311 SGTC_2323 6148992 148.28 µM -0.0629497003149176 0.475724181957146 no 1788 0.474903279081299 2569 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1198 1612-1005 86.7 µM -0.0633904794677925 0.475541730743413 no 1789 0.474727784144651 2623 6998509 SGTC_2551 apiole 73.87 µM -0.063965650754581 0.475303658464405 no 1790 0.474498788750246 2511 10659 A possible DNA adduct former. SGTC_2926 9010726 65.15 µM -0.0648714558774308 0.474928749643551 no 1791 0.474138173808948 2582 2994293 SGTC_2103 5378138 10 µM -0.0649338405610137 0.474902929706259 no 1792 0.474113338284153 2512 244142 SGTC_1702 st027038 51 µM -0.0659131903890043 0.474497607702798 no 1793 0.473723469504734 2565 5521182 SGTC_2763 lisinopril 49.32 µM -0.0662472808224323 0.474359344227064 no 1794 0.473590477384715 2513 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2212 7123476 200 µM -0.0672883507059672 0.473928516869455 no 1795 0.473176075330197 2531 1085715 SGTC_2011 4012611 177 µM -0.0674936378009693 0.473843566216413 no 1796 0.473094363388628 2534 2049887 SGTC_1700 st030840 7.9285 µM -0.0676028315166657 0.473798380823598 no 1797 0.473050900666966 2617 5499307 SGTC_1694 st024011 44.9 µM -0.0680464324980153 0.473614818012398 no 1798 0.472874336063273 2534 2787533 SGTC_2618 avocadyne 43.43 µM -0.0686780682647684 0.473353455776741 no 1799 0.472622937982695 2548 3015189 SGTC_2862 9027634 71.43 µM -0.0688179388284478 0.473295580799091 no 1800 0.472567269409521 2519 5012562 SGTC_469 w7 172 µM -0.0697509320143807 0.472909545788404 no 1801 0.472195951289473 2520 45115570 A P450 inhibitor. SGTC_821 1114-0266 29.2 µM -0.0708882847281819 0.472438989481834 no 1802 0.471743333675581 2585 3123235 SGTC_184 1494-0393 24.714 µM -0.0709970152885878 0.472394006451439 no 1803 0.471700065476381 2515 3090647 SGTC_321 4534-3890 65.3 µM -0.0718277810128524 0.472050321185743 no 1804 0.471369481932465 2561 699746 SGTC_695 3505-6186 243 µM -0.0723343639305462 0.471840759563369 no 1805 0.471167908925514 2598 1819379 SGTC_900 1112-0045 141 µM -0.0723404649878898 0.471838235744618 no 1806 0.47116548131558 2549 56211 YIL048W NEO1 SGTC_1514 1189-1591 158 µM -0.0733120112519704 0.471436351595714 no 1807 0.470778916912304 2641 767698 YMR146C TIF34 SGTC_866 0495-0101 262 µM -0.0733146796396841 0.471435247845912 no 1808 0.470777855236634 2568 635694 SGTC_2426 5582046 32.21 µM -0.0747377788651331 0.470846629671877 no 1809 0.470211674263858 2611 2251934 SGTC_1962 st076595 64.5 µM -0.0750724834091969 0.470708199352296 no 1810 0.470078520542901 2542 279619 SGTC_2360 9040895 200 µM -0.0753515892270644 0.47059276679351 no 1811 0.469967487923814 2576 4914414 SGTC_2243 6634756 200 µM -0.0757186041872613 0.470440980542032 no 1812 0.469821487241293 2728 885676 SGTC_1453 4237-0541 195 µM -0.0764304661908933 0.470146588279359 no 1813 0.469538315986323 2540 739892 SGTC_476 mead acid 10 µM -0.0766716823672916 0.470046836436197 no 1814 0.469442366203422 2545 5312531 An omega 9 fatty acid. SGTC_554 4483-2211 187 µM -0.076715661976733 0.470028649437538 no 1815 0.469424872402034 2621 747107 SGTC_1769 st044406 64.4 µM -0.0773397148608157 0.46977059003254 no 1816 0.469176648806918 2546 670903 SGTC_1993 st073995 70.8 µM -0.0778948595323753 0.469541036336082 no 1817 0.468955844243543 2588 3098394 SGTC_1521 st012942 49.4 µM -0.078035665586749 0.469482814290405 no 1818 0.468899841223562 2769 24207259 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.0785445612725529 0.469272395920039 no 1819 0.468697442457431 2542 688803 SGTC_246 cycloheximide 667 µM -0.0790627051547014 0.469058162419667 no 1820 0.468491373796688 2539 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1383 3049-0032 20.7 µM -0.0799765193607509 0.468680355615333 no 1821 0.468127965486716 2626 712864 SGTC_1461 k072-0203 53.8 µM -0.0811556278291027 0.468192907429521 no 1822 0.467659093463436 2524 5418714 SGTC_1756 st041558 35.5 µM -0.0813176707452265 0.468125921946321 no 1823 0.467594660652908 2595 3955792 SGTC_3284 9108171 64.8615 µM -0.0815392120628492 0.468034342407588 no 1824 0.467506570982564 2610 8687505 SGTC_475 α-linolenic acid 10 µM -0.0831726784865642 0.467359161523136 no 1825 0.46685711842978 2728 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3322 9139058 2.11 µM -0.0833851094075142 0.467271361681237 no 1826 0.466772664123377 2687 4908926 YPR165W RHO1 SGTC_2491 paeonol 100 µM -0.0850174259351556 0.466596762242342 no 1827 0.466123768486776 2552 11092 Increases levels of cortical cytochrome oxidase. SGTC_219 mitoxanthrone 164.414 µM -0.0859138715418472 0.466226322275418 no 1828 0.465767442194204 2630 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1550 gossypolone 36.6 µM -0.0863770455425701 0.466034935422992 no 1829 0.465583346862064 2567 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_873 0591-4978 488 µM -0.0870802793357694 0.465744369155808 no 1830 0.465303850320902 2679 3305145 SGTC_368 fentichlor 4.58 µM -0.0876849876965804 0.465494526801689 no 1831 0.465063525871494 2628 7329 A pesticide. SGTC_185 k048-0037 25.491 µM -0.0900389589737626 0.464522086366035 no 1832 0.464128127879486 2545 6827589 SGTC_1097 itavastatin 7.23 µM -0.0901321833282109 0.464483579118471 no 1833 0.464091087347848 2571 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1031 k035-0009 16 µM -0.0916894869686188 0.46384036881846 no 1834 0.463472375194475 2709 5180959 SGTC_1389 3405-0187 19 µM -0.0927400582630715 0.463406506536983 no 1835 0.463055036118093 2615 799890 SGTC_3255 9139072 49.47 µM -0.093310652083026 0.463170882345961 no 1836 0.46282838493372 2634 17646060 SGTC_1966 st070145 16.1 µM -0.0935751842700782 0.463061649329204 no 1837 0.462723311590991 2559 3748532 SGTC_1435 4092-0789 56.7 µM -0.0941452980994827 0.462826242264405 no 1838 0.462496868734802 2570 2248285 SGTC_3203 9113543 49.47 µM -0.0942830484426253 0.46276936539039 no 1839 0.462442157654718 2718 17018012 SGTC_2043 5101342 149 µM -0.0952499579602833 0.462370151641856 no 1840 0.462058144809144 2604 678451 SGTC_1429 4049-0205 9.46 µM -0.0966415878251895 0.461795647683565 no 1841 0.461505514369674 2561 22774478 SGTC_3019 9081971 49.47 µM -0.0976348838329857 0.461385635826215 no 1842 0.461111111767021 2654 16451803 SGTC_591 4299-0174 154 µM -0.0985181179599924 0.461021089672441 no 1843 0.460760442945531 2617 5509088 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.0986577181841895 0.460963474049743 no 1844 0.46070502051065 2565 66535 A nucleotide analog. SGTC_2512 diallyl trisulfide 49.23 µM -0.0989239587110419 0.4608535938789 no 1845 0.460599322953073 2557 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_828 2074-0507 139 µM -0.0995943594422974 0.460576925941556 no 1846 0.460333186037152 2682 X828 SGTC_1497 4476-2978 41.3 µM -0.100004270588636 0.460407768944811 no 1847 0.460170467502295 2665 1528379 SGTC_490 phenamil 164 µM -0.101256450472399 0.459891079539464 no 1848 0.459673442969886 2691 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1316 1272-0050 65.9 µM -0.101324004893852 0.459863206345685 no 1849 0.459646630552157 2594 7340392 SGTC_991 3996-0057 64.7 µM -0.102425709450847 0.459408667077916 no 1850 0.459209388896446 2663 715343 SGTC_2845 9003024 42.97 µM -0.102736484536637 0.459280457624781 no 1851 0.459086058182827 2762 2990173 SGTC_2821 7996764 71.43 µM -0.102983602973057 0.459178512578609 no 1852 0.458987992342677 2677 2987135 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.103102321716821 0.459129537875609 no 1853 0.458940881191044 2661 6728940 SGTC_2779 methotrexate 400 µM -0.103397145089717 0.45900791791923 no 1854 0.458823888946042 2563 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2449 5812982 45.77 µM -0.104670012144879 0.458482881493731 no 1855 0.45831882903089 2582 776185 SGTC_2743 auranofin 4.32 µM -0.104716613902823 0.458463660414767 no 1856 0.458300339227975 2631 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3308 9128332 17.569 µM -0.105684182029889 0.458064605130537 no 1857 0.457916465484937 2687 17332805 YDL196W YDL196W SGTC_1204 4049-0315 18.3 µM -0.105884902068445 0.457981827204309 no 1858 0.457836836562456 2844 588402 SGTC_1501 4491-0275 38.4 µM -0.106888594425667 0.457567926976994 no 1859 0.457438680839933 2598 5104718 SGTC_2284 7945075 39.21 µM -0.107908009645395 0.457147590098459 no 1860 0.457034331723562 2690 1245402 SGTC_843 0310-0051 143 µM -0.110061406253643 0.456259835259926 no 1861 0.456180337751826 2614 2065037 SGTC_2765 myclobutanil 7.74 µM -0.110793534041436 0.455958059274044 no 1862 0.455890036435941 2695 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1344 1488-0097 29.1 µM -0.111471642161209 0.455678572331059 no 1863 0.455621175853134 2692 747966 SGTC_2457 5731572 11.68 µM -0.111567152447653 0.45563920886603 no 1864 0.455583308962525 2708 2865357 SGTC_726 3448-4391 34.2 µM -0.112186136746304 0.455384112186247 no 1865 0.455337910524824 2724 1356692 SGTC_2193 5925765 200 µM -0.112493051551602 0.455257632839935 no 1866 0.455216239416306 2698 877370 SGTC_2972 9093619 59.92 µM -0.112503439226455 0.455253352166689 no 1867 0.455212121474272 2610 25236256 SGTC_758 0868-0029 16 µM -0.112678366036206 0.455181267083703 no 1868 0.455142776701709 2708 762687 SGTC_2488 5268135 45.7 µM -0.113117810000834 0.455000184406825 no 1869 0.454968577639549 2711 1270356 YLR208W SEC13 SGTC_3101 9120531 49.47 µM -0.113148324834736 0.454987610436365 no 1870 0.454956481639251 2709 24824904 SGTC_3159 9100096 49.47 µM -0.114343062159841 0.454495341451478 no 1871 0.45448292382959 2570 25236875 SGTC_1623 st003709 20.3 µM -0.114494850145933 0.454432805061656 no 1872 0.454422764271387 2597 16192618 SGTC_1699 st031318 29.054 µM -0.115555810560123 0.45399572281613 no 1873 0.454002293135281 2703 5340658 SGTC_2586 curcumin 80 µM -0.115654017597727 0.453955267421368 no 1874 0.453963375126385 2704 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1868 st057644 42.7 µM -0.116159779322809 0.453746931574133 no 1875 0.453762956179303 2590 688665 SGTC_979 1426-2828 121 µM -0.117077363207021 0.4533689884563 no 1876 0.453399373949095 2707 747872 SGTC_3020 9089140 49.47 µM -0.117143210688851 0.453341868193475 no 1877 0.453373284127961 2660 17217859 SGTC_3086 9117350 49.47 µM -0.118150680371674 0.452926954058736 no 1878 0.452974133753168 2616 2679265 SGTC_714 4296-0578 26.1 µM -0.118251602811361 0.452885393203807 no 1879 0.452934151806881 2650 1589775 SGTC_135 0933-0004 26.348 µM -0.118540034586665 0.452766617004072 no 1880 0.452819887841719 2704 21230617 YGL099W LSG1 SGTC_2180 6301957 200 µM -0.119233363123933 0.4524811216347 no 1881 0.452545237613683 2633 845462 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.119571745850836 0.452341792993477 no 1882 0.452411201326913 2602 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_359 0081-0058 15.9 µM -0.119928738779957 0.452194807987947 no 1883 0.452269799259201 2912 3494159 SGTC_2708 st078559 56 µM -0.120599511709176 0.451918647809708 no 1884 0.452004127810105 2628 17250902 SGTC_2774 tamoxifen 10.92 µM -0.121067293560707 0.451726073715407 no 1885 0.451818867269807 2606 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_568 1193-0097 7.48 µM -0.122395581811912 0.451179312716436 no 1886 0.451292868704057 2650 3646150 SGTC_1217 1183-1422 255 µM -0.12338051638837 0.450773945536538 no 1887 0.450902892426769 2739 2849664 SGTC_2262 9014885 67.46 µM -0.123703658337841 0.450640961937728 no 1888 0.450774957488801 2670 6457424 SGTC_1805 st050013 60.3 µM -0.123728038821484 0.450630928787034 no 1889 0.450765305233262 2695 4037144 SGTC_565 1418-0001 44.5 µM -0.123889611380066 0.450564438621943 no 1890 0.450701339247216 2739 2862145 SGTC_2096 5468907 200 µM -0.124469295505342 0.450325899066798 no 1891 0.450471854967709 2753 759785 SGTC_1052 3253-3998 198 µM -0.124611216443197 0.450267501445084 no 1892 0.450415674089412 2618 5450317 SGTC_2126 5251174 33.877 µM -0.125146684518109 0.450047176769457 no 1893 0.450203712442045 2690 790722 SGTC_1303 1160-0052 261 µM -0.125191154966653 0.450028879568655 no 1894 0.450186109734493 2633 3562476 SGTC_449 xestospongin c 11.1929 µM -0.125873303328626 0.449748225495042 no 1895 0.449916107711599 2729 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2298 7976326 193.81 µM -0.126342069723768 0.449555377029192 no 1896 0.449730578111894 2676 2235818 SGTC_1810 st050138 53 µM -0.126826664483195 0.449356029367416 no 1897 0.449538795471344 2615 3444541 SGTC_3184 9108758 49.47 µM -0.127576737631578 0.449047497128283 no 1898 0.449241970678897 2608 902885 SGTC_2536 dehydroabietamide 32.04 µM -0.128608353921966 0.448623206363126 no 1899 0.448833777868083 2750 3983547 SGTC_7 0192-1582 4.227 µM -0.128635107192366 0.448612203860071 no 1900 0.448823192777991 2645 252616 SGTC_649 1123-0311 367 µM -0.128809098191095 0.448540649591872 no 1901 0.448754353096666 2711 693629 YIL048W NEO1 SGTC_2730 imipramine 71.33 µM -0.12941206591098 0.448292690455594 no 1902 0.448515800374436 2646 3696 A tricyclic antidepressant. SGTC_1624 st003710 6.25 µM -0.130266066092127 0.447941533527892 no 1903 0.448177963299892 2758 24207033 SGTC_65 0798-0905 34.986 µM -0.130623698060941 0.447794490692851 no 1904 0.448036497503609 2983 3602145 SGTC_2694 st077685 81.9 µM -0.131230355604127 0.447545075702541 no 1905 0.447796541650479 2627 2838096 SGTC_2238 6671620 73.2395 µM -0.131545451199006 0.447415538693268 no 1906 0.447671917035263 2586 729941 SGTC_1786 berberine 21.6 µM -0.13165869258321 0.447368986094636 no 1907 0.447627129780932 2627 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1278 0874-0585 172 µM -0.131726181885566 0.447341242144109 no 1908 0.447600437908406 2696 766306 SGTC_879 0831-1030 162 µM -0.131835863324263 0.447296154119731 no 1909 0.447557059643817 2642 1549252 SGTC_3317 9138495 8.753 µM -0.132192989841249 0.447149350692099 no 1910 0.447415822878964 2653 17020139 SGTC_412 gemfibrozil 100 µM -0.133227846464866 0.446723994792968 no 1911 0.447006594426489 2646 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1325 1431-0015 227 µM -0.13332075825887 0.446685808358644 no 1912 0.446969855713897 2644 1103340 SGTC_130 0136-0219 337.655 µM -0.134175661425985 0.446334469282806 no 1913 0.446631835616741 2623 234244 SGTC_1922 5578187 25 µM -0.134201144764046 0.446323997054846 no 1914 0.44662176035555 2867 1350412 SGTC_2372 9071633 200 µM -0.13560288436312 0.445748018274073 no 1915 0.446067612563032 2638 21321366 SGTC_2371 9071574 200 µM -0.135927940495584 0.445614468093471 no 1916 0.445939123572797 2626 45596039 SGTC_1855 st056195 39.6 µM -0.135995495591138 0.445586713675949 no 1917 0.445912420939989 2777 4028379 SGTC_138 0850-0259 40.9225 µM -0.136981332672628 0.445181721580803 no 1918 0.445522775190126 2669 6813004 SGTC_2441 5730946 39.09 µM -0.137114391636663 0.44512706395106 no 1919 0.445470188514298 2766 1774275 SGTC_819 1013-0258 27.7 µM -0.137153702097786 0.445110916297346 no 1920 0.445454652679731 2665 5753198 SGTC_1358 1509-0022 2.48 µM -0.139416704290262 0.444181491756064 no 1921 0.444560436575535 2692 3258434 SGTC_2052 5265182 7.135 µM -0.140847423565016 0.443594047329914 no 1922 0.443995238937594 2780 1239884 SGTC_1027 k015-0025 8.67 µM -0.141262457900813 0.443423659948847 no 1923 0.443831303206855 2637 3598955 SGTC_1871 st057448 67.3 µM -0.141339611264391 0.443391986710519 no 1924 0.443800829213252 2806 691747 SGTC_3177 9107506 49.47 µM -0.143087611576513 0.442674489500334 no 1925 0.443110494396758 2712 8897194 SGTC_2332 7982454 138.89 µM -0.144148444555633 0.442239143606732 no 1926 0.44269162546467 2678 2981748 SGTC_3298 9116858 71.43 µM -0.144867105212706 0.441944258393551 no 1927 0.442407899324314 2776 2506942 SGTC_2227 7312221 64.1025 µM -0.14527010362442 0.441778911701143 no 1928 0.442248809077543 2675 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1827 berberine 7.24 µM -0.145585114436691 0.441649672606993 no 1929 0.442124459865836 2666 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2157 5649910 96.377 µM -0.146139888478319 0.44142208126266 no 1930 0.44190547898624 2682 2858091 SGTC_3210 9128157 49.47 µM -0.146740813962237 0.44117557850407 no 1931 0.441668301202125 2812 17590849 SGTC_2490 carminic acid 95.39 µM -0.148105678502399 0.440615788771426 no 1932 0.441129684037511 2623 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2147 5545932 89.7195 µM -0.148388864429648 0.440499656852254 no 1933 0.44101794384069 2688 797404 SGTC_1033 k072-0102 21.3 µM -0.148415509559875 0.44048873019503 no 1934 0.441007430381484 2676 5965931 SGTC_905 2-aminofluorene 215 µM -0.148843288742789 0.440313312360347 no 1935 0.440838645798516 2668 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1945 st075991 56.6 µM -0.148858032815072 0.440307266521539 no 1936 0.440832828567779 2724 1084980 SGTC_2716 st080858 38.6235 µM -0.14952761906649 0.440032715916244 no 1937 0.440568658739487 2760 5296050 SGTC_1563 conessine 56.1 µM -0.15071728707034 0.43954498727492 no 1938 0.440099367951889 2780 441082 An anti-amoebic, histamine inhibitor. SGTC_1678 st019265 80.2 µM -0.150776559795578 0.439520689606694 no 1939 0.440075988712944 2823 5367020 SGTC_3194 9111903 49.47 µM -0.150859358428077 0.439486748344757 no 1940 0.440043330381954 2836 17087251 SGTC_2959 9079155 11 µM -0.151266673966542 0.439319785843938 no 1941 0.439882678531111 2842 16189457 SGTC_3211 9128781 49.47 µM -0.151443164277415 0.43924744414239 no 1942 0.439813070963692 2826 17194361 SGTC_2807 7945238 51.95 µM -0.152103487163647 0.438976802080944 no 1943 0.43955265692659 2780 17148797 SGTC_2698 st077697 67.5 µM -0.154736681778527 0.437897837392189 no 1944 0.438514455192126 2717 3154499 SGTC_3129 9127257 49.47 µM -0.155236423174436 0.437693117716423 no 1945 0.438317467392231 2704 837894 SGTC_1980 st071811 45.7 µM -0.155615568725496 0.437537811399426 no 1946 0.438168026191108 2834 4974850 SGTC_1305 1181-0477 144 µM -0.156525155537634 0.437165264009919 no 1947 0.437809546181244 2809 6252086 SGTC_1645 Cervolide 78 µM -0.156733938030458 0.437079758995915 no 1948 0.43772726947249 2754 23173 A fragrance. SGTC_1261 0712-0010 12.7 µM -0.156954185115035 0.436989561945845 no 1949 0.437640477731882 2782 2840123 SGTC_14 0354-0009 295 µM -0.157283910198594 0.436854536861222 no 1950 0.43751055011633 2643 1713507 SGTC_1049 3226-0134 66 µM -0.15743037311722 0.436794561471723 no 1951 0.437452838809563 2642 5702385 SGTC_1791 st048313 56.1 µM -0.157489087697244 0.436770518730368 no 1952 0.437429703667538 2794 1204976 SGTC_1483 3453-0561 55.9 µM -0.157716980036491 0.436677202443124 no 1953 0.437339909912697 2777 4546991 SGTC_295 k015-0027 31 µM -0.157970961056109 0.436573207637315 no 1954 0.437239840542949 2780 3887424 SGTC_1926 methyl fluorone black 53.6 µM -0.159700240944672 0.43586525537755 no 1955 0.436558605546131 2682 72721 Reacts with homocysteine. SGTC_570 0987-0065 62.6 µM -0.16075665408136 0.435432869905447 no 1956 0.436142533072946 2666 3104428 SGTC_2197 6588183 93.1375 µM -0.161256263609197 0.435228408668687 no 1957 0.435945784474101 2706 884136 SGTC_2871 9038510 12.99 µM -0.161569269104095 0.435100322471504 no 1958 0.435822529500211 2704 4945164 SGTC_406 estrone 100 µM -0.163207870922098 0.434429895284182 no 1959 0.435177384601179 2852 5870 A steroid. SGTC_1781 st038725 66.3 µM -0.164366584205388 0.433955926191587 no 1960 0.434721283857473 2686 4270275 YIL048W NEO1 SGTC_1486 3970-0793 4.53 µM -0.166921506545458 0.432911177285641 no 1961 0.433715905389863 2797 2844330 SGTC_44 0929-0055 61.211 µM -0.167459943843504 0.432691061159812 no 1962 0.433504081305936 2711 1379590 SGTC_1661 st013063 9.66 µM -0.168361219589287 0.432322661454124 no 1963 0.433149557425606 2711 721395 SGTC_1020 4335-0961 93.3 µM -0.16879573888906 0.432145071125365 no 1964 0.432978655053622 2670 669075 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.169969327733659 0.431665487794397 no 1965 0.432517129274751 2704 15053 SGTC_1770 st043884 66.3 µM -0.170702676928247 0.431365858068695 no 1966 0.432228778920785 2704 670149 SGTC_2404 5161160 200 µM -0.172282173106931 0.430720646359299 no 1967 0.431607849301576 2685 2831543 SGTC_1187 1391-0724 117 µM -0.17376552539842 0.430114876975087 no 1968 0.431024869454084 2749 6997986 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.174184397838727 0.429943848134655 no 1969 0.430860273410529 2709 4174840 SGTC_2874 9043904 71.43 µM -0.174824223943563 0.429682627597496 no 1970 0.430608876752849 2799 4463428 SGTC_3137 9097352 49.47 µM -0.176687519855211 0.428922079218563 no 1971 0.429876922176817 3027 44120435 SGTC_207 4185-0010 4.486 µM -0.177353372270623 0.428650359616162 no 1972 0.429615415091709 2756 3761753 SGTC_1952 st077036 64.1 µM -0.178235265419728 0.428290530655934 no 1973 0.429269107654273 2694 2937007 SGTC_1976 st070609 63.5 µM -0.179643422491019 0.427716099840804 no 1974 0.428716256486523 2656 682556 SGTC_743 1275-0778 158 µM -0.18034110466381 0.427431550379565 no 1975 0.428442393892505 2840 2849257 YMR203W TOM40 SGTC_3145 9085516 49.47 µM -0.181045652494401 0.427144239067066 no 1976 0.428165871274076 2803 25236195 SGTC_1745 st081495 74 µM -0.181836508841775 0.426821777583588 no 1977 0.427855516104146 2742 13842402 YBL026W LSM2 SGTC_506 n9-isopropylolomoucine 153 µM -0.182788321432247 0.426433753124759 no 1978 0.427482056188242 2818 6610355 SGTC_2508 celastrol 40.54 µM -0.182949647724449 0.426367992447457 no 1979 0.427418763494061 2709 122724 Celastrol is a natural product and antioxidant. SGTC_310 1273-0058 1.06 µM -0.183721434149142 0.426053421132505 no 1980 0.42711599655173 2820 2734232 SGTC_884 0851-0618 334 µM -0.184018202438277 0.425932474286469 no 1981 0.426999587642604 2874 9642473 SGTC_1321 1326-2144 215 µM -0.185146679553697 0.425472631220272 no 1982 0.426556994738993 2856 3513030 SGTC_1718 roemerine 11.9335 µM -0.185560893466531 0.425303868616377 no 1983 0.426394561677951 2847 235224 An aporphine alkaloid with mutagenic activity. SGTC_419 nsc-638432 893 µM -0.186403155963824 0.424960749006204 no 1984 0.426064308851574 2817 368090 SGTC_1341 1486-1360 280 µM -0.187073630118857 0.424687652888273 no 1985 0.425801451632588 2722 3976547 SGTC_2895 9054447 58.44 µM -0.187643783070987 0.424455447823697 no 1986 0.425577950948877 2751 2697450 SGTC_2544 sphondin 68.51 µM -0.188184705115002 0.424235171807058 no 1987 0.425365930920043 2971 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_141 0443-0274 32.331 µM -0.188600616047765 0.424065819307155 no 1988 0.425202924971223 2854 1627241 SGTC_1361 1608-0041 5.61 µM -0.19327623034696 0.422162953417472 no 1989 0.423371320389301 2755 X1361 SGTC_984 1492-0255 2.91 µM -0.19432994503476 0.421734365230595 no 1990 0.422958769897917 2878 1585198 SGTC_2177 5811945 192 µM -0.194912179467664 0.421497586770643 no 1991 0.422730849611561 2901 5343475 SGTC_1679 SEC14.276 6.7 µM -0.195933940894564 0.421082133633275 no 1992 0.422330935563261 2910 1005053 YMR079W SEC14 SGTC_1506 4226-2149 212 µM -0.199425017865319 0.419663310507013 no 1993 0.420965146039981 2867 991114 SGTC_605 1315-0399 119 µM -0.199512429711009 0.419627798412222 no 1994 0.420930960649008 2871 24020461 SGTC_1101 ebselen 5.29 µM -0.200148086170627 0.419369575171425 no 1995 0.420682383403535 2901 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2087 5276107 200 µM -0.20023454623747 0.41933445510823 no 1996 0.420648575120344 2743 144405 SGTC_126 0417-1624 672.48 µM -0.200915318120111 0.419057948167653 no 1997 0.420382394907178 2799 41912 YDL195W SEC31 SGTC_2029 5175081 200 µM -0.201353023857833 0.418880187731557 no 1998 0.420211272208611 2760 1380876 SGTC_1427 4048-4900 550 nM -0.201412758228874 0.418855929776571 no 1999 0.42018792000118 2888 24132586 SGTC_646 4092-0839 27.3 µM -0.201740086293882 0.418723008277512 no 2000 0.420059961262181 2898 877796 SGTC_2915 7971052 15.16 µM -0.201938434861287 0.418642467333343 no 2001 0.419982427161681 2749 5741558 SGTC_338 4055-0136 114 µM -0.203394959722156 0.41805113901915 no 2002 0.41941316951822 2767 2900563 SGTC_785 1270-0111 65.3 µM -0.205080651018919 0.417367003679729 no 2003 0.418754556697383 2736 6741994 SGTC_3325 9138760 55.175 µM -0.205846794517408 0.417056147998989 no 2004 0.418455293555446 2809 43844959 SGTC_3163 9099914 49.47 µM -0.206235470005208 0.416898466303495 no 2005 0.418303491142478 2864 16268368 SGTC_385 1494-0393 12.4 µM -0.20841251360861 0.416015509665126 no 2006 0.417453443201391 2815 3090647 SGTC_1625 st003711 30.1 µM -0.209797268949533 0.415454106325754 no 2007 0.4169129523469 2975 24207034 YER133W GLC7 SGTC_1244 0416-0015 52.5 µM -0.210347630000504 0.415231028457961 no 2008 0.416698181687811 2806 96201 SGTC_1064 honokiol 6.76 µM -0.211087787623895 0.414931063432807 no 2009 0.416409384798269 2864 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1549 4'-methoxyflavonol 74.6 µM -0.211761515483919 0.414658063626232 no 2010 0.416146546891539 2781 97141 SGTC_2725 haloperidol 53.21 µM -0.212604830448308 0.414316403892763 no 2011 0.415817601714904 2786 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3082 9117008 49.47 µM -0.21370431697217 0.413871056474756 no 2012 0.415388822328487 2813 41448529 SGTC_2207 7258803 200 µM -0.214297506058835 0.413630830974392 no 2013 0.415157531371862 2868 3666799 SGTC_1218 1348-1416 30.7 µM -0.215915488489957 0.412975756517292 no 2014 0.414526811891964 2769 6787668 SGTC_3002 9075603 71.4286 µM -0.21596656696806 0.412955080248522 no 2015 0.414506904135272 2803 20105405 SGTC_1471 k673-0312 37 µM -0.217076434046504 0.412505872276182 no 2016 0.414074389495159 2820 24099884 SGTC_753 1322-0200 289 µM -0.217428888802074 0.412363243563092 no 2017 0.413937059828198 2947 5403907 SGTC_1822 st052468 42 µM -0.2178569445128 0.412190036793919 no 2018 0.413770287330855 2836 2873678 SGTC_1825 st052143 62.6 µM -0.21836096392873 0.411986114298345 no 2019 0.413573938958838 2965 674173 SGTC_45 0kpi-0036 14.9 µM -0.218734462124162 0.41183501504198 no 2020 0.41342845103538 2915 2795021 SGTC_1654 st012436 41.8 µM -0.220165588811198 0.411256171778573 no 2021 0.412871097621069 2829 4323132 SGTC_959 1222-0044 107 µM -0.220224697640517 0.41123226836295 no 2022 0.412848081409335 2904 6083612 SGTC_162 k030-0015 37.8 µM -0.220246795789884 0.411223332028856 no 2023 0.412839476753434 2882 1809920 YMR134W ERG29 SGTC_3006 9075424 71.4286 µM -0.224743645174043 0.409405802916909 no 2024 0.411089354544662 2837 7465181 SGTC_313 3474-0040 5.03 µM -0.225646487802126 0.409041126749102 no 2025 0.410738190567058 2798 1043375 YIL048W NEO1 SGTC_2587 piperic acid 92.2 µM -0.226142080910586 0.408840980238779 no 2026 0.410545458188422 2893 5370536 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.22633687519951 0.408762318584661 no 2027 0.410469710086441 2789 91467 include heat shock SGTC_907 3448-6986 75.5 µM -0.227473169032286 0.408303534776136 no 2028 0.410027915210541 2973 590582 SGTC_1120 ficusin 1.78878 µM -0.227736817892893 0.408197103286366 no 2029 0.409925423943856 2947 6199 A DNA cross-linker. SGTC_1482 3346-2049 8.48 µM -0.228274726780721 0.407979977734238 no 2030 0.409716335501505 2910 3826804 SGTC_380 3970-0968 6 µM -0.229938902620958 0.407308416609814 no 2031 0.409069623103014 2825 2891601 SGTC_2358 9037157 4 µM -0.230619425156409 0.407033877054076 no 2032 0.4088052376363 2912 2388925 SGTC_2557 derrustone 83.84 µM -0.231189824521719 0.406803799075937 no 2033 0.408583667376882 2927 629853 An antioxidant. SGTC_1643 st009866 20.2 µM -0.232052865246297 0.406455741583136 no 2034 0.408248476854652 2908 3156273 YOR207C RET1 SGTC_1611 st001856 99.4 µM -0.232689239614438 0.406199144154481 no 2035 0.408001362719102 2850 647478 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.234498728695408 0.405469746543675 no 2036 0.407298910016418 2833 5106787 A p450 inhibitor. SGTC_1569 carminic acid 40.6 µM -0.235487742142716 0.405071217815612 no 2037 0.406915095868224 2954 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1431 4049-0260 9.09 µM -0.238759693355574 0.403753469593478 no 2038 0.405645963204536 2798 3854841 SGTC_2912 7964298 10.93 µM -0.239244326142276 0.403558380666907 no 2039 0.405458066580288 2900 2975850 SGTC_2665 lovastatin 100 µM -0.240034985514388 0.403240152264484 no 2040 0.405151567392474 2852 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1288 0973-0013 65.5 µM -0.240067193077709 0.403227190565495 no 2041 0.405139083358888 2911 4315430 SGTC_2669 eugenol 100 µM -0.240509437948505 0.403049223101 no 2042 0.404967673768675 2893 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1488 4013-0813 75.9 µM -0.243446802901263 0.401867684776191 no 2043 0.403829645327266 2834 2910057 SGTC_159 3970-0959 50 µM -0.244915100546207 0.401277405734841 no 2044 0.403261084582881 2924 6615653 SGTC_248 streptozotocin 5.23457 mM -0.245752730823723 0.40094076583294 no 2045 0.402936825160728 2922 5300 DNA alkylating agent. SGTC_467 ro 31-8220 72.8 µM -0.245792456667523 0.400924802016785 no 2046 0.402921448338339 2902 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2497 7-hydroxyflavone 100 µM -0.246488308327516 0.40064520112687 no 2047 0.402652126952511 3009 5281894 SGTC_849 0386-0493 241 µM -0.246737904237971 0.400544923125713 no 2048 0.402555534973551 2848 726119 SGTC_2568 diosmetin 100 µM -0.247289275114181 0.400323426835148 no 2049 0.402342179155882 2984 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1287 0971-0001 34.6 µM -0.248472552169124 0.399848189970396 no 2050 0.401884402244757 2850 4665869 SGTC_2673 kobusone 100 µM -0.249714428659946 0.399349577459299 no 2051 0.401404099589587 2864 6710676 An epoxy ketone and protein crosslinker. SGTC_374 0880-0231 82.3 µM -0.250389921300747 0.399078436521426 no 2052 0.401142911534158 2928 6833587 SGTC_47 0149-0135 24.25 µM -0.250808592831932 0.398910407320091 no 2053 0.400981048882962 2827 5239155 SGTC_1211 1056-0033 32.3 µM -0.251089611865242 0.398797633935055 no 2054 0.400872413611398 2949 6741922 SGTC_881 0833-0569 170 µM -0.251941732105666 0.398455728412781 no 2055 0.400543051095573 2870 5418700 SGTC_2213 7173844 200 µM -0.253412701429603 0.397865698822978 no 2056 0.399974656799589 2870 892728 SGTC_18 0111-0177 500 nM -0.253687166681819 0.397755632182143 no 2057 0.399868624649958 2870 721752 SGTC_738 1315-0003 72.4 µM -0.256140278614136 0.396772242404832 no 2058 0.398921260638286 3018 6251474 SGTC_748 act1.228 77.9 µM -0.256392409354582 0.396671206724623 no 2059 0.398823924239346 2841 4421505 YNR035C ARC35 SGTC_3249 9135183 49.47 µM -0.25667709836841 0.396557132393024 no 2060 0.398714026111234 3022 4902779 SGTC_791 1348-1292 225 µM -0.256990339613681 0.396431627468373 no 2061 0.398593115281606 2921 5437054 SGTC_2624 nerol 100 µM -0.257247354204278 0.396328658631939 no 2062 0.398493915157085 2833 637566 A natural product oil. SGTC_613 3914-0030 117 µM -0.257920350471298 0.396059067581968 no 2063 0.398234189343474 2800 1145395 SGTC_640 3381-0960 37.1 µM -0.258052125154067 0.396006286662704 no 2064 0.398183339526049 2922 1745025 SGTC_2131 toluylene red 5.2905 µM -0.259105737454559 0.395584342327747 no 2065 0.397776829043142 2901 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_514 4466-0038 2.65 nM -0.259458344859029 0.395443159530867 no 2066 0.397640808878672 2904 5722064 SGTC_3259 9138485 49.47 µM -0.260088651154853 0.3951908212461 no 2067 0.397397695916237 3163 17646153 SGTC_3335 9143315 29.6265 µM -0.260952946041477 0.394844878888897 no 2068 0.397064396941549 2901 4899691 SGTC_1118 chelidonine 707.474 nM -0.261762316455229 0.394520995729457 no 2069 0.396752346697293 3001 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1845 st056753 3.01 µM -0.262450808590717 0.394245541415732 no 2070 0.396486952722635 2807 5375839 SGTC_1080 nisoldipine 24.4 µM -0.262705343818669 0.394143719463907 no 2071 0.396388848825897 2831 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2945 9067681 61.76 µM -0.263351261766668 0.393885364824868 no 2072 0.396139926230366 2808 16456930 SGTC_3025 9087895 49.47 µM -0.264162250346852 0.393561051270079 no 2073 0.395827449000849 3009 17173641 SGTC_2719 novobiocin 32.65 µM -0.264169591148615 0.39355811602732 no 2074 0.395824620865185 2985 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_63 0099-0242 26.702 µM -0.264725821416137 0.393335723204011 no 2075 0.395610342162036 3029 3898502 YLR359W ADE13 SGTC_2846 9008642 19.48 µM -0.265138019367188 0.393170940043041 no 2076 0.395451569926129 3010 2992898 SGTC_113 0099-0221 2.5 µM -0.265601909228233 0.392985515049105 no 2077 0.395272907523703 3060 89219 SGTC_2742 clothiapine 36.27 µM -0.265644577200401 0.392968461123543 no 2078 0.395256475498524 2935 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_1037 k284-1091 78.7 µM -0.265915893007456 0.392860023946643 no 2079 0.395151992393978 2846 3334711 SGTC_1068 loratadine 26.9 µM -0.265922315881683 0.39285745700802 no 2080 0.395149519050926 2923 3957 A H1 histamine antagonist. SGTC_3295 9122362 53.5725 µM -0.267816074745664 0.392100809064957 no 2081 0.394420448362061 2983 4730473 SGTC_1034 k072-0165 12.7 µM -0.267930658122186 0.392055040539311 no 2082 0.394376347199973 3041 5835461 SGTC_812 4251-0442 148 µM -0.268476881218866 0.391836880863397 no 2083 0.394166133986375 2997 5723007 SGTC_566 0958-0068 16.5 µM -0.269708993657105 0.391344904242429 no 2084 0.393692070472438 3061 6815365 SGTC_2132 5317594 122.667 µM -0.269884555353174 0.391274817420804 no 2085 0.393624534739038 2865 794577 SGTC_2164 5685496 200 µM -0.27298934637494 0.390035924221194 no 2086 0.392430702508181 2958 759046 SGTC_596 1155-0152 116 µM -0.273561207525208 0.389807857945984 no 2087 0.392210924499973 2909 280313 SGTC_1339 1486-1321 22.7 µM -0.274836103464065 0.389299548162746 no 2088 0.391721079609712 2905 3469382 SGTC_1790 st045711 43.5 µM -0.275006770619732 0.389231516346432 no 2089 0.391655518297507 3061 585119 SGTC_1104 tacrolimus 29.8 µM -0.276917315382237 0.388470161889408 no 2090 0.39092179828753 2922 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_101 0490-5701 117.494 µM -0.278176257741603 0.387968705703476 no 2091 0.390438529716593 2872 4661669 SGTC_1374 2889-5571 141 µM -0.281228556383079 0.386753704801756 no 2092 0.389267551654123 2965 2853281 SGTC_2206 7254556 146.969 µM -0.281856615576615 0.386503836160288 no 2093 0.38902672852571 2939 4398905 SGTC_2045 5106652 78.05 µM -0.284808459826333 0.385330098887237 no 2094 0.387895445268958 3036 673349 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.284849427940009 0.385313816159525 no 2095 0.387879751060567 2862 88881 An O-methylated flavonoid and antioxidant. SGTC_945 3381-0768 11.3 µM -0.285434073701237 0.38508147144393 no 2096 0.387655802883627 3054 1126236 YIL048W NEO1 SGTC_1602 st001878 87.6 µM -0.286200865902513 0.384776802254426 no 2097 0.387362140288725 3090 595405 YLR310C CDC25 SGTC_456 gingerol 170 µM -0.287474397784183 0.384270947694463 no 2098 0.386874551297419 3091 442793 A herb. SGTC_519 k048-0011 62.8 µM -0.288678421140282 0.383792883524361 no 2099 0.386413738709291 3031 6836379 SGTC_1860 st056228 74.6 µM -0.288739658813515 0.383768573484535 no 2100 0.386390305655341 3025 688679 SGTC_1450 4112-4260 37.6 µM -0.289268565730493 0.38355862785512 no 2101 0.386187932717189 3068 1633175 SGTC_152 4469-0003 551.229 µM -0.289347320953976 0.383527369482827 no 2102 0.386157801657323 2892 697280 SGTC_1312 1218-2183 165 µM -0.289664280988593 0.383401574004902 no 2103 0.386036542463689 2914 6744073 SGTC_198 3454-2873 16.191 µM -0.290427688178112 0.383098642521365 no 2104 0.385744531991293 2927 710957 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.290626609395858 0.383019719314197 no 2105 0.385668453369045 2983 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1178 0988-0033 191 µM -0.290806803847344 0.382948230257484 no 2106 0.385599540708222 3061 5392207 SGTC_206 4546-0025 72.014 µM -0.290909145842413 0.382907629602102 no 2107 0.385560403157474 2981 6620745 YIL048W NEO1 SGTC_1721 st082152 9.2685 µM -0.291511963615288 0.382668508570176 no 2108 0.385329897683703 2857 5296051 SGTC_433 pimozide 108 µM -0.292591663943803 0.382240333338548 no 2109 0.38491714313657 2872 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2951 9072950 58.06 µM -0.2937065560838 0.38179835321403 no 2110 0.384491072066762 2924 16488155 SGTC_2150 5556613 200 µM -0.29457296412979 0.381454986738151 no 2111 0.38416005884439 2953 743190 SGTC_1420 4'-methoxyflavone 42 µM -0.294590667324935 0.381447971750242 no 2112 0.384153296177087 3010 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_19 0279-0214 38.434 µM -0.296177455470548 0.380819356715302 no 2113 0.383547282401889 2935 3566274 YBR002C RER2 SGTC_977 1348-1378 135 µM -0.298442274929925 0.379922680834073 no 2114 0.382682813769943 2907 X977 SGTC_3124 9127567 49.47 µM -0.298719668926721 0.379812900656233 no 2115 0.382576974139075 3144 17592030 SGTC_3275 9138069 49.47 µM -0.299863800837622 0.379360206698743 no 2116 0.382140523573132 3039 17617007 SGTC_1347 1493-0251 600 nM -0.300425436845887 0.379138046962717 no 2117 0.381926331740711 3072 3986378 SGTC_2819 7996655 46.38 µM -0.301076051124826 0.378880741042563 no 2118 0.381678251335821 3002 6456960 SGTC_2391 6285546 200 µM -0.30216504721663 0.378450183361135 no 2119 0.381263123928723 2906 846083 SGTC_2713 st079149 53.4 µM -0.302342241152134 0.378380140240233 no 2120 0.381195590167003 3018 3103253 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.302531864359783 0.378305188369526 no 2121 0.381123323255739 2985 5357218 A potent inhibitor of glutathione S-transferases. SGTC_302 1094-0063 18.9 µM -0.304058728497824 0.377701835862541 no 2122 0.380541574485482 2918 5440289 SGTC_903 1134-0042 114 µM -0.304221648211528 0.377637474427657 no 2123 0.380479516551724 2955 701009 SGTC_257 daunorubicin 18.5 µM -0.304726092712705 0.37743821517332 no 2124 0.380287387533852 3044 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2458 5808907 16.39 µM -0.305267315601143 0.377224464462946 no 2125 0.380081283481788 3105 2731747 SGTC_1158 4092-0494 91.8 µM -0.306161420549404 0.376871428836282 no 2126 0.379740872397316 3089 1148199 SGTC_2795 7780010 54.55 µM -0.307020690742927 0.376532244625001 no 2127 0.379413811685074 3080 953673 SGTC_2537 larixol 68.93 µM -0.307245948294706 0.376443343291211 no 2128 0.379328087032201 2949 6708759 SGTC_305 1682-2595 20.8 µM -0.310569680477046 0.375132345721144 no 2129 0.378063889783957 3008 226033 SGTC_4 0960-0234 25.671 µM -0.311985094548026 0.37457449297839 no 2130 0.377525925601623 3044 6821112 SGTC_712 r015-0009 80.6 µM -0.312817853714212 0.374246402734898 no 2131 0.377209525174974 3057 6813872 YLR060W FRS1 SGTC_1818 st052136 56.3 µM -0.314315288108152 0.373656673123367 no 2132 0.376640793981104 3047 674169 SGTC_524 r073-0010 27.8 µM -0.314575559311784 0.373554201506754 no 2133 0.376541969270553 2941 2772106 SGTC_2781 5567276 71.43 µM -0.314669182189341 0.373517343342723 no 2134 0.376506422737786 3112 2853274 SGTC_2970 9090938 41.86 µM -0.314841382297718 0.373449553320247 no 2135 0.376441044905627 3185 17217104 SGTC_1007 4101-0031 70 µM -0.3150585637495 0.373364061075161 no 2136 0.376358594422408 3114 1146276 SGTC_701 4424-0219 185 µM -0.315463674469163 0.373204608201075 no 2137 0.376204813795592 3139 2911779 SGTC_3220 9131269 49.47 µM -0.315666517193357 0.373124776812578 no 2138 0.376127821780106 2956 17722206 SGTC_2975 9084847 53.72 µM -0.315951371357745 0.37301267795262 no 2139 0.376019709408448 3042 27211724 SGTC_157 1348-1695 65.819 µM -0.317858033714356 0.372262625000398 no 2140 0.375296313567295 2950 5380510 SGTC_319 1348-1596 45.5 µM -0.318464827630934 0.372024022649514 no 2141 0.375066185187314 3158 5380505 SGTC_657 3534-0529 86.7 µM -0.31947041753785 0.371628714719875 no 2142 0.374684910195845 3124 1049549 SGTC_1371 2421-0008 32.7 µM -0.320858599509066 0.371083228269475 no 2143 0.374158774595878 2993 2827552 SGTC_2059 5238311 157 µM -0.320915738755044 0.371060780929265 no 2144 0.374137123233503 2943 703021 SGTC_1414 3917-0015 5.4 µM -0.321130362138814 0.370976469348255 no 2145 0.374055801089428 3079 6618702 SGTC_1281 0884-0031 11.8 µM -0.322565148790186 0.37041299418418 no 2146 0.37351229558014 2992 1548255 SGTC_894 0960-0238 55.9 µM -0.323291274032733 0.370127933209053 no 2147 0.373237330903015 3078 6741907 YDL195W SEC31 SGTC_77 0828-0286 12.516 µM -0.323412268416164 0.370080440374517 no 2148 0.373191519757707 3008 745345 SGTC_720 r052-1644 49.9 µM -0.3235901430338 0.370010624451396 no 2149 0.373124175754655 3093 1422863 YOR257W CDC31 SGTC_1466 k213-0079 57.5 µM -0.324386428714571 0.369698134253253 no 2150 0.372822746526732 2977 3657981 SGTC_3352 9151559 45.5865 µM -0.325150616554502 0.369398321262615 no 2151 0.372533540950663 3053 17159339 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.326164130822497 0.369000812823105 no 2152 0.372150089081132 3385 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_635 k038-0028 24.7 µM -0.326715841141259 0.36878448645183 no 2153 0.371941408858102 3022 4035102 SGTC_1289 0976-0073 69.1 µM -0.328493634067951 0.368087694503362 no 2154 0.371269228387238 3091 3391136 SGTC_3083 9117465 49.47 µM -0.328548294692324 0.368066277563554 no 2155 0.371248567507221 3070 16420915 SGTC_1660 st012960 28.1 µM -0.331953493754429 0.366732875022332 no 2156 0.369962188102403 3084 24207266 SGTC_703 3875-0075 71.8 µM -0.332422636836113 0.366549294265121 no 2157 0.369785073888031 3001 2850814 SGTC_1815 st051655 58.2 µM -0.332727509290018 0.366430010742074 no 2158 0.369669991086917 3088 5984156 SGTC_1919 st067113 52.3 µM -0.333569297738161 0.366100722031896 no 2159 0.36935229467585 3123 1268243 SGTC_1930 st074634 34.3 µM -0.334934765897539 0.365566791354956 no 2160 0.368837147926575 2969 684253 YOR116C RPO31 SGTC_2369 9071472 200 µM -0.335116178177389 0.365495874390883 no 2161 0.368768724677722 3134 17296037 SGTC_1426 4048-4480 71.7 µM -0.33680223254407 0.364836988984383 no 2162 0.368132994991151 3105 14224343 SGTC_10 0279-0212 42.575 µM -0.338734593007687 0.364082341466927 no 2163 0.367404839107355 3014 39851 YBR002C RER2 SGTC_3244 9134489 49.47 µM -0.340051468200453 0.363568361900227 no 2164 0.366908884443421 3078 16584271 SGTC_3100 9120536 49.47 µM -0.34304425114961 0.362401185588656 no 2165 0.365782585063353 3042 16421196 SGTC_391 gliotoxin 8.33 µM -0.344000824536895 0.362028393826203 no 2166 0.365422833001566 3175 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_914 3820-6779 408 µM -0.344104567333227 0.361987971478436 no 2167 0.365383824092355 2961 2893481 SGTC_74 000s-0487 160.283 µM -0.348241733787616 0.360377224895237 no 2168 0.363829323959157 3040 677548 SGTC_832 4083-0019 164 µM -0.348467871019922 0.360289252679096 no 2169 0.363744419385045 3145 1990758 SGTC_3115 9123671 49.47 µM -0.348800887971406 0.360159715435686 no 2170 0.363619398364004 3114 3286988 SGTC_474 dl-dihydrosphingosine 5 µM -0.349017292691062 0.360075546731609 no 2171 0.363538163619386 3162 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2228 7354201 200 µM -0.349459647308097 0.359903517918444 no 2172 0.363372130120825 3045 753451 SGTC_3088 9117578 49.47 µM -0.349531721543153 0.359875491407794 no 2173 0.363345080189128 3093 678341 SGTC_2539 epi(13)torulosol 80 µM -0.349685656822435 0.359815635248412 no 2174 0.363287309554346 3119 6708597 SGTC_3281 9140613 49.47 µM -0.349973239215421 0.359703820987306 no 2175 0.363179390597496 3048 16013766 SGTC_1328 1441-0025 69.2 µM -0.350374318397341 0.359547898349049 no 2176 0.363028898662875 2987 4562601 SGTC_2189 6047310 154.431 µM -0.351850462080434 0.358974237608567 no 2177 0.362475205996711 3003 711535 SGTC_2249 haloperidol 116.36 µM -0.354022353075726 0.358130772938998 no 2178 0.361661065676824 3001 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1417 3966-0327 90.4 µM -0.355265154192452 0.357648435917545 no 2179 0.361195478948937 3081 651118 SGTC_105 0111-0055 734.78 µM -0.356718896633569 0.357084519975649 no 2180 0.360651128779789 3112 5179370 SGTC_1737 st035557 69.7 µM -0.35776126901321 0.356680369113745 no 2181 0.360260988753097 3043 5716916 SGTC_842 0271-0008 11.1 µM -0.357811623492159 0.356660849635978 no 2182 0.360242145715873 3170 1221709 SGTC_3331 9141060 1.957 µM -0.358338302918159 0.356456709421648 no 2183 0.36004507853688 3032 4906567 YPR165W RHO1 SGTC_2924 9010168 62.78 µM -0.358667834850049 0.356329004211093 no 2184 0.359921796773221 3127 2993929 SGTC_1369 1866-0067 208 µM -0.359219365521496 0.356115302734602 no 2185 0.359715495280974 3191 3531355 SGTC_1638 st008370 60.6 µM -0.361470412052337 0.35524355943318 no 2186 0.358873909812304 3068 24207134 SGTC_3061 glucosamine 200 µM -0.361643484378361 0.355176566492604 no 2187 0.358809232574454 3139 91431 and experimental redox chemotherapeutic SGTC_1411 3909-8223 150 µM -0.362445925567413 0.354866015587546 no 2188 0.358509412714666 3141 X1411 SGTC_1929 genistein trimethyl ether 50.5 µM -0.363142480417735 0.354596521665166 no 2189 0.358249226346765 3228 136420 SGTC_1740 st038286 13.222 µM -0.363744924223702 0.354363497556749 no 2190 0.3580242466449 3255 716786 SGTC_2115 tiliquinol 12.7705 µM -0.364617516848607 0.35402607707657 no 2191 0.357698468612461 3099 71208 A bioactive hydroxyquinoline. SGTC_3067 9117431 49.47 µM -0.366636891306778 0.353245650488697 no 2192 0.356944943186218 3073 17150885 SGTC_1295 1013-0063 9.78 µM -0.366812598134904 0.35317777428324 no 2193 0.356879404879746 3180 6826038 SGTC_994 3910-0338 138 µM -0.367279268002441 0.352997520647815 no 2194 0.356705358435183 3229 3479481 SGTC_1143 3454-2408 5.08 µM -0.369987461434745 0.351952119270441 no 2195 0.355695916431701 3110 X1143 SGTC_2854 9024559 71.43 µM -0.37371480155439 0.350515142247277 no 2196 0.354308255966445 3136 3163529 SGTC_1108 betulinic acid 729.144 nM -0.374079741221543 0.350374563956126 no 2197 0.35417249524681 3096 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_895 0964-0006 13.7 µM -0.374134508807786 0.350353468720055 no 2198 0.354152122828891 3193 6738897 SGTC_1527 coumarin 137 µM -0.37504075487449 0.350004470282094 no 2199 0.353815078535407 3237 323 A hepatotoxic, DNA x-linker. SGTC_3276 9139060 49.47 µM -0.375271351500917 0.349915686941901 no 2200 0.353729335024301 3025 4870619 SGTC_1792 st045773 43.6 µM -0.376021964106327 0.349626746087403 no 2201 0.353450283644681 3043 2919270 SGTC_952 1185-0122 232 µM -0.377237452947918 0.349159040504059 no 2202 0.352998574693592 3028 678600 SGTC_2892 9047358 58.44 µM -0.378675425807777 0.348606021477907 no 2203 0.352464452028505 3095 6466771 SGTC_1268 0828-0275 2.46 µM -0.381300752642107 0.347597197185086 no 2204 0.351490047618613 3176 745337 SGTC_1717 st033143 58.0435 µM -0.381829699118447 0.347394071236337 no 2205 0.351293844058198 3242 674616 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.382560567237055 0.347113475479633 no 2206 0.351022806359972 3212 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2475 5812728 15.03 µM -0.382947941802745 0.346964788143287 no 2207 0.35087918173188 3050 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2185 6113692 200 µM -0.38339480900314 0.346793294807065 no 2208 0.350713525828155 3200 874150 SGTC_870 0573-2213 57.6 µM -0.384741659417291 0.346276606670507 no 2209 0.350214413429981 3118 3916321 SGTC_2031 5180455 200 µM -0.386234131840861 0.345704388031715 no 2210 0.349661638844427 3070 29949 SGTC_2696 st077691 74.316 µM -0.386422259107374 0.345632284421229 no 2211 0.349591983779898 3236 757133 SGTC_1464 k208-0027 110 µM -0.387145455953598 0.345355156644051 no 2212 0.34932426368298 3277 X1464 SGTC_2226 7298446 200 µM -0.389009583437635 0.34464120870555 no 2213 0.348634528556797 3180 3283010 SGTC_2729 fluphenazine 10.66 µM -0.392098770349707 0.34345928996175 no 2214 0.347492618020916 3083 3372 An atypical antipsychotic. SGTC_509 pifithrin 175 µM -0.392908565913207 0.343149715748335 no 2215 0.34719350733138 3202 4817 A p53 inhibitor. SGTC_1556 plumbagin 1.48 µM -0.395561450722248 0.34213629073699 no 2216 0.346214290077193 3171 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1267 0828-0272 9.49 µM -0.396800002472069 0.341663541752774 no 2217 0.345757474453071 3256 745334 SGTC_721 1187-1332 279 µM -0.399019743676813 0.340816899188986 no 2218 0.344939328249106 3039 25730 SGTC_2295 7971645 200 µM -0.399760855671881 0.340534406151478 no 2219 0.344666332316514 3111 2978226 YKL099C UTP11 SGTC_611 3453-1652 23.7 µM -0.400176379298663 0.34037605823591 no 2220 0.344513305452245 3207 1560575 SGTC_1686 st019653 115.5 µM -0.400631679931794 0.340202584390974 no 2221 0.344345658934956 3231 97252 SGTC_1641 st009299 47.1 µM -0.400762670838273 0.34015268187994 no 2222 0.344297432358029 3197 4046054 SGTC_2697 mebhydrolin 72.4 µM -0.400823609571278 0.340129467514224 no 2223 0.34427499756804 3279 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1047 2043-3044 82 µM -0.400840588587718 0.340122999534014 no 2224 0.344268746786292 3126 669592 SGTC_1189 1431-2119 7.28 µM -0.401233372748431 0.33997338561849 no 2225 0.34412415617438 3165 3107275 SGTC_2989 9073649 71.4286 µM -0.401342440069247 0.339931845670731 no 2226 0.344084010656965 3218 21367202 SGTC_3241 9133421 49.47 µM -0.40135698175686 0.339926307394679 no 2227 0.344078658282948 3165 17018221 SGTC_1647 st011722 22.4 µM -0.401467337845673 0.339884278840197 no 2228 0.344038040421224 3233 2854783 SGTC_2962 9082311 13.18 µM -0.403836436064012 0.338982500546587 no 2229 0.343166500507364 3066 16459453 SGTC_2476 5806916 10.51 µM -0.405014024114371 0.338534603721336 no 2230 0.342733601208176 3083 2870194 SGTC_860 0443-0016 25.1 µM -0.405085930865716 0.338507261304205 no 2231 0.342707173873367 3147 5337942 SGTC_3316 9136639 10.545 µM -0.406679930904504 0.337901364392232 no 2232 0.342121541182733 3222 4903665 SGTC_2902 5787006 60.46 µM -0.407709051089836 0.337510407384763 no 2233 0.341743645842182 3077 591003 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.408222570796431 0.337315389660283 no 2234 0.341555139469843 3127 5355888 SGTC_1113 artemisinin 1.17947 µM -0.40960174254819 0.336791842450092 no 2235 0.341049059225212 3218 2240 An anti-malaria and mitochondrial poison. SGTC_1366 1683-0113 21.9 µM -0.411837166355554 0.335943925243144 no 2236 0.340229388938005 3125 708623 SGTC_1498 4478-3555 97.6 µM -0.413721564156745 0.335229803287558 no 2237 0.339539016289685 3204 3437919 SGTC_2053 5265679 138 µM -0.415086580129341 0.334712880652758 no 2238 0.339039261556684 3098 764595 SGTC_931 2812-0076 566 µM -0.415370349689567 0.334605458250047 no 2239 0.338935404382915 3108 3450959 SGTC_499 genistein 192 µM -0.415464801083207 0.334569706199469 no 2240 0.33890083871493 3209 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1318 1280-3875 124 µM -0.415665172855264 0.33449386578741 no 2241 0.338827514651824 3187 373245 SGTC_2357 9067248 200 µM -0.419149499314258 0.333176135632279 no 2242 0.337553438455723 3215 9150235 SGTC_2826 7992541 19.48 µM -0.419626744187865 0.332995807181669 no 2243 0.337379073947709 3159 2985066 SGTC_1385 3091-4834 14.1 µM -0.421017658365514 0.332470466346429 no 2244 0.336871093724723 3237 4072814 SGTC_3134 9127454 49.47 µM -0.421146236346918 0.332421919723556 no 2245 0.336824150351866 3272 24262820 SGTC_448 monastrol 171 µM -0.421513818603124 0.332283148815528 no 2246 0.336689961374384 3185 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_82 0054-0107 293.755 µM -0.421899203254538 0.332137681774541 no 2247 0.336549295808322 3187 3104697 SGTC_3039 9090270 49.47 µM -0.423391039585976 0.331574812806613 no 2248 0.336004990662934 3287 17173750 SGTC_429 1112-0049 25.5 µM -0.423464550622106 0.331547086952591 no 2249 0.335978178611571 3082 2836170 SGTC_396 dithiazanine 1.25 µM -0.425410110912757 0.330813623882093 no 2250 0.335268868307389 3151 10578 An antihelmenthic. SGTC_3065 9113888 49.47 µM -0.425473881159266 0.33078959390103 no 2251 0.335245628939169 3332 16648368 SGTC_2987 9018338 71.43 µM -0.42578847965185 0.330671056724828 no 2252 0.335130991125549 3286 5055682 SGTC_510 ag-490 170 µM -0.42761998917454 0.329981302025609 no 2253 0.334463905186183 3274 5328779 SGTC_1943 st076331 65.2 µM -0.42799055146241 0.329841816785394 no 2254 0.334328999712739 3263 24208415 SGTC_1530 rhein 70.4 µM -0.428429806510905 0.329676505197058 no 2255 0.334169113930073 3192 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1364 1653-0028 37.6 µM -0.428594135140682 0.329614669433784 no 2256 0.334109307183459 3199 5718652 SGTC_73 0327-0325 16.231 µM -0.428744001346051 0.329558279844892 no 2257 0.334054767650568 3240 53298 SGTC_1035 k081-0041 55.2 µM -0.429074765461971 0.329433838201009 no 2258 0.333934407883786 3305 731709 SGTC_3192 9110362 49.47 µM -0.430427346447766 0.328925160438778 no 2259 0.333442403165175 3234 16649480 SGTC_2116 5511452 16.8835 µM -0.431093860622466 0.32867461464391 no 2260 0.333200062241641 3272 870744 SGTC_793 0488-0545 106 µM -0.432060455602527 0.328311403880927 no 2261 0.332848737291379 3141 292548 SGTC_2710 st078562 53.7235 µM -0.432388104680799 0.32818832223239 no 2262 0.332729681085333 3124 17250908 SGTC_2336 9001819 198.65 µM -0.43334821385509 0.32782776386117 no 2263 0.33238090817798 3369 2989602 SGTC_370 0180-0345 38.7 µM -0.433458410648194 0.327786390933386 no 2264 0.332340886948655 3067 3989527 SGTC_1045 1348-1485 165 µM -0.434479755095828 0.327403032051541 no 2265 0.33197004647746 3168 6810614 SGTC_983 1491-0821 12.2 µM -0.435464905345996 0.327033430932589 no 2266 0.331612503655109 3274 46495113 SGTC_1812 st052057 4.327 µM -0.435507332343332 0.32701751730346 no 2267 0.331597108970784 3138 3645418 SGTC_422 cantharidin 155 µM -0.436133460901464 0.326782703952132 no 2268 0.331369950596349 3116 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1499 4480-0877 67.3 µM -0.43765577511465 0.326212085545254 no 2269 0.330817916452193 3191 2861909 SGTC_409 arachidonic acid 100 µM -0.439541677173731 0.32550574519389 no 2270 0.330134545074102 3193 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3079 9117512 49.47 µM -0.440939722720968 0.324982529210758 no 2271 0.32962831767851 3237 7185044 SGTC_673 1082-0474 110 µM -0.441138700600326 0.324908090125472 no 2272 0.329556293827233 3197 3098046 SGTC_2383 9036125 200 µM -0.443583379358621 0.323994089153671 no 2273 0.328671912241352 3156 79580 SGTC_453 enantio-paf c16 10 µM -0.443725419376787 0.323941016666621 no 2274 0.328620557580991 3278 13871343 A lipid and platelet activating factor SGTC_1356 1502-0781 85.8 µM -0.443920079561717 0.323868288751095 no 2275 0.328550183322767 3176 567702 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.443972472967277 0.323848714950506 no 2276 0.328531242906723 3159 442882 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.444184302036738 0.323769582095943 no 2277 0.328454670381681 3209 4620898 SGTC_1490 4089-0339 670 nM -0.446510518233302 0.322901103678889 no 2278 0.327614258249774 3290 742542 SGTC_42 0133-0086 60.653 µM -0.446571852015455 0.322878218126044 no 2279 0.327592111455937 3140 162923 Model of phenazepam hydroxylation. SGTC_356 1634-0012 32.5 µM -0.447608124263506 0.322491653985466 no 2280 0.327218019410383 3300 735457 SGTC_569 4130-2812 160 µM -0.448544629778193 0.322142471156853 no 2281 0.326880092162878 3236 743552 SGTC_1956 st077085 54 µM -0.450042018421991 0.321584485146821 no 2282 0.326340071657095 3217 24208685 SGTC_2848 9016370 25.97 µM -0.450204943706813 0.321523797009944 no 2283 0.326281335963375 3349 7894410 SGTC_644 1498-1197 63.3 µM -0.450463549715467 0.321427478483968 no 2284 0.326188115552448 3302 6741615 SGTC_1391 3442-0225 151 µM -0.451435781718531 0.321065475433361 no 2285 0.325837749631356 3153 5227075 SGTC_1573 oleylamine 1.06 µM -0.454494761098632 0.3199275982931 no 2286 0.324736380894241 3226 5356789 An amine of the fatty acid oleic acid. SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.457143072678038 0.318943847065586 no 2287 0.323784106360633 3323 61125 An anti-inflammatory. SGTC_2853 9015042 58.44 µM -0.45888381112567 0.318297919622085 no 2288 0.323158802375371 3105 6457456 SGTC_2541 muurolladie-3-one 83.07 µM -0.460571907102099 0.317672053148874 no 2289 0.322552885351406 3374 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_76 0433-0009 400.328 µM -0.462324768035036 0.317022725842398 no 2290 0.321924220282642 3281 2841569 SGTC_1089 terbinafine 2.25 µM -0.464114880382945 0.316360180241247 no 2291 0.321282720580196 3320 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1937 st074714 47.2 µM -0.464557028501547 0.316196625670464 no 2292 0.321124355586271 3192 17250970 SGTC_1575 cyproterone acetate 48 µM -0.466910439062177 0.315326683570836 no 2293 0.320281978139308 3244 9880 An androgen receptor antagonist and liver toxin. SGTC_1646 st011709 75.6 µM -0.466991582850261 0.315296706850734 no 2294 0.320252950089835 3321 5757843 SGTC_1298 1079-1278 263 µM -0.467181445009453 0.315226571361568 no 2295 0.320185033869558 3295 2840950 SGTC_3050 9093513 49.47 µM -0.467324432726136 0.315173755787876 no 2296 0.320133889237544 3272 25236664 SGTC_1006 4099-6547 255 µM -0.468877345000454 0.3146003978954 no 2297 0.319578655318378 3341 3146833 SGTC_908 3448-7491 47.7 µM -0.469578181267125 0.314341785140571 no 2298 0.319328208050058 3227 1203031 SGTC_300 r073-0011 5.04 µM -0.471756898840808 0.313538407622771 no 2299 0.318550159395723 3333 2735780 SGTC_54 0159-0055 9 µM -0.472306767043785 0.313335789431877 no 2300 0.318353920445613 3433 3319099 SGTC_2026 5148700 152 µM -0.473148388520327 0.31302577363419 no 2301 0.318053658236634 3221 79838 SGTC_838 0109-0203 71.4 µM -0.473979875401376 0.312719620728232 no 2302 0.317757129103032 3272 759422 SGTC_2174 5790901 200 µM -0.47409868083376 0.31267588718935 no 2303 0.317714769634222 3307 786020 SGTC_176 1486-1328 72.834 µM -0.474102771181193 0.312674381536063 no 2304 0.317713311284264 3296 22310231 SGTC_1583 clindamycin 39.6 µM -0.475646511662621 0.312106355429469 no 2305 0.317163116668854 3220 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1835 st008666 49.2 µM -0.475985327076573 0.311981746502487 no 2306 0.317042415655223 3195 690455 SGTC_658 3253-0951 102 µM -0.477646497653962 0.311371115691403 no 2307 0.316450915189514 3276 1184878 SGTC_876 0720-0963 56.8 µM -0.478910143058732 0.310906958598323 no 2308 0.316001277402558 3405 765861 SGTC_328 k915-0120 63.5 µM -0.479163187286757 0.310814047533052 no 2309 0.315911270380583 3324 6624543 SGTC_2893 9048488 25.97 µM -0.479952376164309 0.310524355995857 no 2310 0.315630628532464 3272 6467338 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.480477447614083 0.310331680438871 no 2311 0.315443967814726 3272 2724278 An inhibitor of dopamine biosynthesis. SGTC_393 acivicin 6.25 µM -0.480925835265868 0.31016718528081 no 2312 0.315284605139861 3192 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2416 tofa 880 nM -0.481045131668454 0.310123426686912 no 2313 0.315242211467133 3203 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_909 3448-9333 149 µM -0.483114512122715 0.309364794538471 no 2314 0.314507215217621 3231 3344074 SGTC_890 0929-0006 47.2 µM -0.484650385279758 0.308802270089066 no 2315 0.31396218316249 3248 1378169 SGTC_2114 5491910 81.25 µM -0.485217973736466 0.308594500150582 no 2316 0.313760866825785 3352 2849228 SGTC_415 dibenzyl ketone 100 µM -0.486642708611767 0.308073235468892 no 2317 0.313255775994555 3312 7593 SGTC_3064 1327-0027 10 µM -0.486922347771158 0.307970969883675 no 2318 0.313156680606195 3281 16000455 YPR107C YTH1 SGTC_1814 st052110 31.539 µM -0.487966164481019 0.307589372102446 no 2319 0.312786903773596 3371 674163 SGTC_3146 9095609 49.47 µM -0.490625897502429 0.30661797018446 no 2320 0.31184553310762 3294 17173999 SGTC_253 dyclonine 31.25 µM -0.490755643451843 0.306570618332382 no 2321 0.311799642932094 3355 3180 An oral anasthetic. SGTC_730 1436-0052 41.2 µM -0.492503695163684 0.30593296752999 no 2322 0.311181655176945 3351 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.493062024848807 0.305729424895761 no 2323 0.310984381180982 3346 17037758 SGTC_3112 9123419 49.47 µM -0.493216584071485 0.305673089950964 no 2324 0.3109297805401 3354 17015854 SGTC_986 1493-0483 84 µM -0.493671183412708 0.305507420716876 no 2325 0.310769209816763 3361 40079 SGTC_1687 st020778 55.3625 µM -0.494226157556858 0.305305225956987 no 2326 0.31057323418219 3314 4259299 SGTC_2072 5231554 129 µM -0.495093068392986 0.304989501580975 no 2327 0.310267213249699 3401 789545 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.495732416821197 0.304756747195234 no 2328 0.310041606342085 3441 16725076 SGTC_1353 1498-1206 8.11 µM -0.495821366156443 0.304724371504764 no 2329 0.310010224449911 3390 6756808 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.496083594516748 0.304628934787696 no 2330 0.309917716668753 3395 5377381 SGTC_2770 toltrazuril 17.5 µM -0.496115221974996 0.304617425028847 no 2331 0.309906560084601 3372 68591 Kills coccidiodes. SGTC_1692 fluoroquinolonic acid 71 µM -0.496608711210649 0.304437861136927 no 2332 0.309732504464378 3366 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_670 4204-0025 119 µM -0.497556031643428 0.304093295653174 no 2333 0.30939850032081 3346 719039 SGTC_1741 st038134 10.228 µM -0.498129396318464 0.303884832230384 no 2334 0.309196421117132 3481 1272587 SGTC_2259 7964009 200 µM -0.498927160034983 0.303594888090277 no 2335 0.308915349729997 3391 313134 SGTC_2006 4011487 200 µM -0.49992525524976 0.303232308289556 no 2336 0.308563854252613 3421 45595294 SGTC_1472 k841-0093 193 µM -0.50170189800665 0.302587383685915 no 2337 0.307938614600428 3412 X1472 SGTC_787 4152-0075 138 µM -0.501955641237532 0.302495324613924 no 2338 0.307849362204856 3299 9566539 SGTC_539 4859-0462 2.54 µM -0.502307836939754 0.302367567400883 no 2339 0.307725498684823 3371 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3221 9128209 49.47 µM -0.502333022888137 0.302358432252557 no 2340 0.307716641891296 3304 16460723 SGTC_830 4076-0286 57.8 µM -0.502478972383462 0.302305497620998 no 2341 0.307665320060546 3353 6866659 SGTC_1408 3909-7976 48.8 µM -0.503470944491551 0.301945828054523 no 2342 0.30731660172956 3330 24152374 SGTC_1630 st005209 31.3 µM -0.504370073549529 0.301619987743846 no 2343 0.307000671914907 3407 3367314 SGTC_625 k213-0058 121 µM -0.50459308546849 0.301539193716318 no 2344 0.306922333675715 3352 3655420 SGTC_2211 7117706 200 µM -0.50567594379358 0.301147028141385 no 2345 0.30654207930978 3358 822771 SGTC_386 1509-0011 3.07 µM -0.506360225735755 0.300899328660791 no 2346 0.306301895541843 3338 3107280 SGTC_1949 st076024 69.1 µM -0.506649264822289 0.300794728590628 no 2347 0.306200467473375 3233 2921930 SGTC_1640 st009078 66.4 µM -0.507572479410968 0.300460737307574 no 2348 0.305876597402343 3374 690618 SGTC_731 3966-0296 387 µM -0.507866549261262 0.30035438686464 no 2349 0.305773467514928 3325 660956 SGTC_2793 7325131 81.82 µM -0.508155104007842 0.300250047498574 no 2350 0.305672286737239 3291 4176441 SGTC_1951 sophoraflavanone G 9.2 µM -0.508220566871272 0.300226378868224 no 2351 0.305649334462703 3277 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_551 k048-0028 34.9 µM -0.510103499948577 0.299545950504127 no 2352 0.304989476663011 3413 6836383 SGTC_733 4069-0007 56.1 µM -0.511072722009801 0.299195979105954 no 2353 0.304650067931322 3405 5717425 YNL287W SEC21 SGTC_2239 6685329 187.64 µM -0.511836899443382 0.29892017710848 no 2354 0.304382581606671 3385 805680 SGTC_575 k072-0246 11.9 µM -0.513183089875115 0.298434599868529 no 2355 0.30391162679708 3359 6796779 SGTC_221 trifluoperazine 10.304 µM -0.515722541448584 0.297519586326844 no 2356 0.303024104326333 3388 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2461 5755302 26.15 µM -0.516369037103038 0.297286846143648 no 2357 0.302798343465251 3410 2788904 SGTC_555 4296-0685 37 µM -0.516761540070701 0.297145584613946 no 2358 0.302661315406738 3362 2908540 YHR072W ERG7 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.518117733434487 0.296657727984846 no 2359 0.302188064086964 3384 3256 An antibiotic and ribosome inhibitor. SGTC_2803 7707263 71.43 µM -0.518384252955811 0.296561897400323 no 2360 0.302095099660361 3272 2199229 SGTC_725 1497-0963 19 µM -0.519114813330852 0.296299287596462 no 2361 0.301840339440586 3415 3549977 SGTC_2658 polymyxin b sulfate 77.05 µM -0.520357212853719 0.295852935343643 no 2362 0.301407313105595 3351 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3154 9100113 49.47 µM -0.520939914284083 0.29564369681426 no 2363 0.301204314538175 3301 25237525 SGTC_562 3772-2733 112 µM -0.521760279209149 0.295349232567563 no 2364 0.300918624409717 3413 2876874 YIL048W NEO1 SGTC_447 ml7 120 µM -0.522432798382277 0.295107937226572 no 2365 0.300684512399616 3413 4216 Selective myosin light chain kinase inhibitor. SGTC_366 0181-0206 4.31 µM -0.522703782810927 0.295010735509056 no 2366 0.300590202702613 3492 274874 SGTC_947 3447-0010 211 µM -0.522779702346446 0.294983505928043 no 2367 0.300563783105804 3402 748350 SGTC_852 0418-0143 439 µM -0.523767812031503 0.294629212518607 no 2368 0.300220021835899 3415 5369229 SGTC_2203 7227154 166.4 µM -0.52384037515135 0.294603202260083 no 2369 0.300194784287432 3409 896304 SGTC_2085 5307070 144.047 µM -0.524210371307284 0.294470593571153 no 2370 0.300066114056368 3294 2840351 SGTC_3085 9117376 49.47 µM -0.52460419091374 0.294329476701227 no 2371 0.299929186374526 3411 16480349 SGTC_1671 st016596 74.5 µM -0.525862116770553 0.293878935081056 no 2372 0.299492005948418 3425 2829167 SGTC_1310 1188-0297 994 nM -0.526565931018662 0.293626994596242 no 2373 0.299247527949321 3345 1588352 SGTC_3286 9117135 37.221 µM -0.52659451530729 0.293616764550138 no 2374 0.299237600780544 3304 3438150 SGTC_3035 9091303 49.47 µM -0.526896049292934 0.29350885844597 no 2375 0.299132888762215 3403 25237002 SGTC_2154 5570129 200 µM -0.526908787027586 0.293504300560401 no 2376 0.299128465766596 3419 673366 SGTC_550 4123-0385 25.7 µM -0.529569352150945 0.29255300201961 no 2377 0.298205274137508 3336 5731123 SGTC_1286 0929-0070 131 µM -0.531612262792866 0.291823522851234 no 2378 0.297497284898404 3438 1420408 SGTC_3193 9111931 49.47 µM -0.531762707947935 0.291769835659834 no 2379 0.297445177117942 3336 17087244 SGTC_845 0330-0138 4.51 µM -0.531916054381353 0.291715117867807 no 2380 0.297392068748369 3381 9039800 SGTC_2597 laccaic acid a 100 µM -0.533361386123229 0.29119962295258 no 2381 0.296891720899316 3380 5491415 A textile dye. SGTC_771 0250-0039 27.3 µM -0.534232310126026 0.290889202947934 no 2382 0.296590408792611 3317 3005115 SGTC_1637 st007924 17.4 µM -0.534463321479579 0.290806890443384 no 2383 0.296510509697297 3383 683336 SGTC_741 4582-0002 126 µM -0.536064652541669 0.290236613873443 no 2384 0.295956934224251 3344 2912688 SGTC_2078 5212016 200 µM -0.54033545727114 0.288718234158184 no 2385 0.294482854988219 3389 1899708 SGTC_2788 5282734 71.43 µM -0.540383174919289 0.288701290470758 no 2386 0.294466404277466 3467 743706 SGTC_1662 st014054 52 µM -0.540710724090075 0.288584996232118 no 2387 0.294353492797914 3402 2838777 SGTC_2939 9044578 71.43 µM -0.541344852276487 0.288359915817102 no 2388 0.294134955425234 3369 2653634 SGTC_1594 piperine 70.1 µM -0.543648662326763 0.287542888089166 no 2389 0.293341633165286 3394 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1981 st071826 47 µM -0.544673851697597 0.287179665133409 no 2390 0.292988925938934 3390 11838600 SGTC_2222 6885208 172.143 µM -0.546157612475706 0.286654356039136 no 2391 0.292478800093034 3403 609514 SGTC_2471 5466956 24.79 µM -0.546343597903993 0.286588542106731 no 2392 0.292414886316584 3334 724419 SGTC_2890 9046729 58.44 µM -0.547251615367977 0.286267328493317 no 2393 0.292102939958665 3311 903329 SGTC_609 0986-0026 86.3 µM -0.547861404482243 0.286051709953869 no 2394 0.291893535922482 3408 2848610 SGTC_3333 9141820 12.094 µM -0.548128800130286 0.285957184466376 no 2395 0.291801733238168 3328 1939433 SGTC_2855 9016525 58.44 µM -0.548341011822752 0.285882177308467 no 2396 0.291728885969803 3423 43811474 SGTC_2120 5538279 151.968 µM -0.548431663807859 0.28585013881653 no 2397 0.291697769865315 3438 2058197 SGTC_2473 5854593 8.94 µM -0.548745077023485 0.285739384550589 no 2398 0.291590203354506 3350 2872951 SGTC_924 2046-0044 21.3 µM -0.549571483770053 0.285447446047055 no 2399 0.291306661110747 3439 3623589 SGTC_3059 1327-0034 3 µM -0.552066916604751 0.284566766198798 no 2400 0.290451253695602 3381 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1254 0550-0035 264 µM -0.552327145034543 0.284475002011574 no 2401 0.290362117944064 3450 15121435 SGTC_2978 9011784 42.97 µM -0.552352176328317 0.284466175987526 no 2402 0.29035354467847 3400 2994934 SGTC_1796 st049173 110.4 µM -0.552594936133736 0.284380585765406 no 2403 0.290270405134448 3433 94134 SGTC_2135 5326629 150.42 µM -0.553120458648528 0.284195343597246 no 2404 0.290090464196248 3362 5020077 SGTC_1763 st044482 94.5 µM -0.553311747712203 0.284127930172476 no 2405 0.290024979062992 3417 88505 SGTC_1432 4049-0298 68.4 µM -0.553759420749889 0.283970192700761 no 2406 0.28987175155782 3455 741646 SGTC_2233 sulbentine 40.3845 µM -0.554314346972277 0.283774722782063 no 2407 0.289681866639455 3422 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2957 9076800 11.52 µM -0.555825678609504 0.283242690863279 no 2408 0.289165014693758 3369 16459615 SGTC_2661 dactinomycin 12.96 µM -0.557140583586305 0.282780196306664 no 2409 0.288715690635614 3412 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_542 3381-0244 89.3 µM -0.557218829068668 0.282752686283425 no 2410 0.288688963270573 3498 1112843 SGTC_1163 k060-0048 49.9 µM -0.557696579053173 0.282584743933188 no 2411 0.288525797045808 3445 6809982 SGTC_1330 1469-0054 61.8 µM -0.55872911282725 0.282221943608977 no 2412 0.288173303722606 3464 7102664 SGTC_2334 9017922 200 µM -0.559239574980653 0.282042665897097 no 2413 0.287999113800643 3426 3163164 SGTC_1821 st053465 65.6 µM -0.560150048916331 0.281723037592941 no 2414 0.287688547448146 3410 675086 SGTC_1465 k213-0056 144 µM -0.561213621313915 0.281349884267483 no 2415 0.287325959129769 3356 24048857 YMR208W ERG12 SGTC_3165 9101544 49.47 µM -0.561408331611822 0.281281596195185 no 2416 0.287259602792981 3454 5002184 SGTC_688 0527-0193 473 µM -0.562642410594369 0.280848970775904 no 2417 0.286839203325534 3382 4007154 SGTC_1615 st002656 86.5 µM -0.562876041169831 0.280767104204801 no 2418 0.286759647926468 3495 1584458 SGTC_352 k048-0007 5.11 µM -0.564783612388412 0.280099103645928 no 2419 0.286110477406295 3447 6811911 SGTC_2155 5570423 76 µM -0.566984225387678 0.279329442711947 no 2420 0.285362449517797 3371 797402 SGTC_1610 st001799 48.1 µM -0.570333200114768 0.278160119500105 no 2421 0.28422586351801 3370 621897 SGTC_1477 0139-0234 16 µM -0.570825470185646 0.277988440645345 no 2422 0.284058977915701 3460 620880 SGTC_2733 amorolfine 100 µM -0.571089641368183 0.277896332447196 no 2423 0.28396943996986 3463 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_549 1661-1316 519 µM -0.571310803261299 0.27781923169605 no 2424 0.283894489941734 3520 2857282 SGTC_1991 st073000 8.92 µM -0.571830827433844 0.277637983693929 no 2425 0.283718295149533 3565 4301969 YIL048W NEO1 SGTC_3167 9103034 49.47 µM -0.573583497977088 0.277027537801181 no 2426 0.283124840640715 3485 5127859 SGTC_1633 st005664 67.9 µM -0.574091418061569 0.276850754780866 no 2427 0.282952970212831 3435 2063822 SGTC_2124 5246320 200 µM -0.575421853375066 0.276387955081739 no 2428 0.28250301399096 3460 579342 SGTC_1370 2001-0092 44.6 µM -0.575605368823542 0.276324147953321 no 2429 0.282440975664709 3573 790957 SGTC_1377 2944-0135 198 µM -0.575637884380299 0.2763128432593 no 2430 0.282429984299511 3471 1894137 SGTC_2381 9035592 200 µM -0.575806944069261 0.276254069880125 no 2431 0.282372839684597 3442 4749657 SGTC_2402 5553605 200 µM -0.5766401046434 0.275964512339963 no 2432 0.282091300661898 3530 6758546 SGTC_2726 cimetidine 79.27 µM -0.577626061930376 0.275622044352245 no 2433 0.281758303763426 3457 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_3009 9080819 71.4286 µM -0.578114708871605 0.275452392435882 no 2434 0.281593338554589 3451 17027216 SGTC_1939 st074455 53.6 µM -0.578584027630011 0.275289499393623 no 2435 0.281434942327875 3535 1644229 SGTC_2594 a-mangostin 100 µM -0.579145258977641 0.275094767231877 no 2436 0.281245581843092 3502 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1801 st050089 28.441 µM -0.579553967338305 0.274952999142878 no 2437 0.281107721616357 3490 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.580861424931959 0.274499725100847 no 2438 0.280666926271779 3520 5357218 A potent inhibitor of glutathione S-transferases. SGTC_980 1473-0395 201 µM -0.581671278862899 0.274219147109923 no 2439 0.280394060481936 3449 768876 SGTC_2306 7482397 179.52 µM -0.583569382611059 0.273562094979253 no 2440 0.279755032155797 3511 891448 SGTC_299 1273-0059 1.44 µM -0.58383965956277 0.273468598673082 no 2441 0.279664096410528 3473 2848077 SGTC_1552 6-methylflavone 10.6 µM -0.585657236240334 0.272840259591292 no 2442 0.27905293848305 3479 689013 SGTC_961 1252-1571 372 µM -0.58689305598965 0.272413444147762 no 2443 0.278637766876278 3527 6813498 SGTC_2321 7390090 138.78 µM -0.587448135179332 0.272221844264799 no 2444 0.278451386877854 3409 649046 SGTC_2141 5621638 7.665 µM -0.588526663560641 0.271849753997175 no 2445 0.278089421116594 3517 2856238 SGTC_2734 clemastine 41.6 µM -0.591658883727162 0.270770580563068 no 2446 0.277039517326927 3436 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1153 4055-0057 267 µM -0.593704436860733 0.27006696308094 no 2447 0.276354907492413 3434 882706 SGTC_3204 9114183 49.47 µM -0.594050571078699 0.269947992398648 no 2448 0.276239144743148 3483 17027248 SGTC_3104 9120930 49.47 µM -0.594185688675653 0.269901557901158 no 2449 0.276193961839474 3530 17014836 SGTC_2753 fluvastatin 17.09 µM -0.594385391962262 0.269832935215552 no 2450 0.276127188324999 3466 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2464 5717415 7.67 µM -0.59569319558639 0.269383759555635 no 2451 0.275690102344926 3411 5285744 SGTC_3117 9124945 49.47 µM -0.597092912917073 0.268903431078225 no 2452 0.275222674653892 3405 17592065 SGTC_1012 4112-3522 18 µM -0.598354805222659 0.268470767691753 no 2453 0.274801607546291 3523 3112398 SGTC_2320 7373003 200 µM -0.600371766628635 0.267779942315896 no 2454 0.274129249781238 3505 5415828 SGTC_789 1309-1135 70.6 µM -0.601308976458535 0.267459245517478 no 2455 0.273817105955185 3530 3092424 SGTC_195 4234-0266 16.654 µM -0.601888621501747 0.267260998120466 no 2456 0.273624139412072 3459 2303354 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.602977577648464 0.266888759220392 no 2457 0.273261802864849 3475 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_3135 9127742 49.47 µM -0.603345915522888 0.266762909246729 no 2458 0.273139296857191 3468 3643468 SGTC_1802 st050112 57.9 µM -0.603928825687794 0.266563807681947 no 2459 0.272945481584345 3512 4662563 SGTC_3196 9111891 49.47 µM -0.605437057606167 0.266048997827725 no 2460 0.272444317277307 3539 18891510 SGTC_2244 6635614 200 µM -0.605517430698209 0.266021577950131 no 2461 0.272417623257472 3375 836499 SGTC_2583 asiatic acid 100 µM -0.60575422616599 0.265940801738748 no 2462 0.272338984800804 3565 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_3318 9139014 38.6185 µM -0.60642955708502 0.265710499590076 no 2463 0.272114773125343 3524 16643984 SGTC_869 0564-0080 44.1 µM -0.60700931899591 0.265512869194399 no 2464 0.271922363851004 3485 6843321 SGTC_2655 perillic acid 100 µM -0.607131308228696 0.265471294759699 no 2465 0.271881887127988 3474 5702197 An apoptosis inducer. SGTC_1749 st037932 54.2 µM -0.607738336176024 0.265264466247745 no 2466 0.271680516373789 3522 594497 SGTC_2964 9083345 53.42 µM -0.607768499568257 0.265254191013809 no 2467 0.271670512140126 3461 17741579 SGTC_330 1488-0319 80.1 µM -0.608212049279038 0.265103118048391 no 2468 0.271523422049914 3490 6846614 SGTC_623 k072-0108 16.9 µM -0.608264043504938 0.265085411685027 no 2469 0.271506182306564 3502 5382803 SGTC_689 0833-0039 98 µM -0.608870937554469 0.264878781508873 no 2470 0.27130499456898 3513 5374726 SGTC_2098 5376439 882.5 nM -0.610422610771414 0.264350853365817 no 2471 0.270790946936366 3548 2844116 SGTC_1337 1486-1011 40.3 µM -0.61082217557939 0.264214995601439 no 2472 0.270658655467754 3560 X1337 SGTC_1294 1000-1494 117 µM -0.611161443553387 0.26409966754663 no 2473 0.270546352953863 3494 712797 YDL207W GLE1 SGTC_2856 9022925 19.48 µM -0.611672730293797 0.263925913262688 no 2474 0.270377153773741 3516 4944862 SGTC_1616 st002734 56.1 µM -0.612879426407711 0.263516064138141 no 2475 0.269978033882739 3492 4026101 SGTC_1176 0848-0131 83.3 µM -0.614740591161285 0.262884565028167 no 2476 0.269363024332999 3551 6769040 SGTC_2162 5663267 200 µM -0.615328695656921 0.26268518031271 no 2477 0.269168835258101 3545 6456493 SGTC_2279 7948423 32.93 µM -0.616429175399796 0.262312293274859 no 2478 0.268805651292762 3581 1247112 SGTC_2423 st077119 87.2 µM -0.617049381568251 0.262102261859607 no 2479 0.268601077298415 3504 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1628 st004252 77.7 µM -0.617604987391991 0.261914180421122 no 2480 0.268417878091127 3534 692968 SGTC_311 1315-0136 58 µM -0.617741192715327 0.26186808331039 no 2481 0.268372976873147 3590 6759207 SGTC_3153 9100258 49.47 µM -0.619801573107402 0.261171279369267 no 2482 0.267694216437069 3484 25236848 SGTC_392 N-ethylmaleimide 8.33 µM -0.620118799699332 0.261064080617772 no 2483 0.267589787953703 3496 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_483 fpl-64176 144 µM -0.620541674184917 0.260921215998182 no 2484 0.267450612962423 3565 3423 SGTC_1468 k284-1086 134 µM -0.621850340573635 0.260479348861514 no 2485 0.267020140628439 3572 15996457 SGTC_49 0717-0965 32.132 µM -0.62205038297683 0.260411839135735 no 2486 0.266954369583197 3656 5889349 YGL099W LSG1 SGTC_2877 9040724 71.43 µM -0.622260236459598 0.260341028082497 no 2487 0.266885381592811 3564 6463895 SGTC_1581 himbacine 57.9 µM -0.622281680094588 0.260333792895702 no 2488 0.266878332642185 3530 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1151 3909-8316 15.3 µM -0.622385876355545 0.260298638044851 no 2489 0.266844082591448 3572 800431 SGTC_1091 telmisartan 47.6 µM -0.622406909093466 0.260291542091098 no 2490 0.266837169250577 3619 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1502 4534-4282 27.7 µM -0.624541966194415 0.259571742705371 no 2491 0.266135859377304 3527 3278949 SGTC_1078 idebenone 36.1 µM -0.625159631780935 0.25936369874852 no 2492 0.265933146742211 3552 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_83 0170-0301 39.027 µM -0.625812056149963 0.259144040828718 no 2493 0.265719111559127 3505 3089716 SGTC_260 nsc-65238 3.989 µM -0.626110066508308 0.259043738853133 no 2494 0.265621374961105 3512 3246252 SGTC_488 nitrendipine 139 µM -0.626203195452204 0.259012398365504 no 2495 0.265590835781707 3574 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1404 3909-7820 48.3 µM -0.626902994547231 0.258776959194426 no 2496 0.265361412118789 3559 23741373 SGTC_2543 pimpinellin 60.67 µM -0.627124096985668 0.258702594912456 no 2497 0.265288946328766 3495 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_3141 9094609 49.47 µM -0.628284524587081 0.258312485039325 no 2498 0.264908783780449 3484 25236309 YDL196W YDL196W SGTC_201 4262-0159 12.803 µM -0.628977379176014 0.258079708216024 no 2499 0.264681932836626 3507 1341029 SGTC_1229 0139-0193 12.2 µM -0.630210192491097 0.257665791791413 no 2500 0.264278535773326 3603 3090752 SGTC_401 neomycin 50 µM -0.63052657709908 0.257559621430497 no 2501 0.264175059959622 3510 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_3280 9140961 49.47 µM -0.631231180954021 0.257323256561211 no 2502 0.263944688485404 3524 4901226 SGTC_559 1550-0661 158 µM -0.631540476147234 0.257219536687281 no 2503 0.263843596224834 3564 5830875 SGTC_2172 5754775 163.918 µM -0.631560282421698 0.257212895538977 no 2504 0.263837123272566 3476 2263357 SGTC_2996 9066192 71.4286 µM -0.63196176025958 0.257078297121736 no 2505 0.263705932465983 3539 6472854 SGTC_20 0481-0013 4.944 µM -0.632833986404599 0.256786003141695 no 2506 0.263421030072221 3555 182045 SGTC_3265 9137266 49.47 µM -0.632999987959085 0.256730393528287 no 2507 0.263366825424154 3523 17224265 SGTC_2385 9074692 200 µM -0.63477630237507 0.25613573062517 no 2508 0.262787160487161 3527 17046906 SGTC_667 1498-1044 59 µM -0.635471095990697 0.255903327754704 no 2509 0.26256060605295 3567 6739982 SGTC_2425 5628681 7.85 µM -0.636131619494844 0.255682490037182 no 2510 0.262345318953973 3569 5714958 SGTC_1260 0700-1617 7.75 µM -0.636353024458656 0.255608488350345 no 2511 0.262273175773676 3568 2853078 SGTC_2255 7941087 197.44 µM -0.636391766592057 0.255595540453685 no 2512 0.262260552979009 3610 935561 SGTC_1109 tnp00067 928.257 nM -0.637781296067212 0.255131376392602 no 2513 0.261808028320077 3531 676295 SGTC_1234 0326-0494 15.5 µM -0.638294216292975 0.254960149908759 no 2514 0.26164108811433 3622 1547813 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.638483315596751 0.254897038679716 no 2515 0.261579555727485 3552 688664 SGTC_2356 9061756 188.97 µM -0.63971526715499 0.254486079392837 no 2516 0.261178864028567 3540 20104043 SGTC_834 0312-0008 75.7 µM -0.639795255839744 0.254459408457436 no 2517 0.261152858653411 3589 6385573 YIL048W NEO1 SGTC_3110 9122132 49.47 µM -0.639817454759748 0.254452006845653 no 2518 0.261145641727992 3646 918317 SGTC_2394 5221648 200 µM -0.641087052567206 0.254028882613208 no 2519 0.26073306288385 3624 788586 SGTC_2066 5222451 176 µM -0.641579809596368 0.25386475888933 no 2520 0.260573022947379 3597 2281147 SGTC_3253 9135987 49.47 µM -0.64169978600492 0.253824806496594 no 2521 0.260534064104448 3584 4182430 SGTC_1888 azatryptophan 97.5 µM -0.641970888500775 0.253734540960631 no 2522 0.26044604251423 3549 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2872 9044037 25.97 µM -0.641972764675337 0.25373391633348 no 2523 0.260445433411019 3567 6465195 SGTC_2818 7996756 12.99 µM -0.642345401793402 0.253609871783614 no 2524 0.26032447069191 3568 2241621 SGTC_2083 5306046 65.942 µM -0.64246318920064 0.253570668988605 no 2525 0.260286241431833 3603 539837 SGTC_3103 9120822 49.47 µM -0.642584874785487 0.253530172119469 no 2526 0.260246750011352 3667 17141819 SGTC_3171 9103192 49.47 µM -0.642611064450084 0.253521456663604 no 2527 0.260238250911625 3623 13018434 SGTC_2127 5253358 187.912 µM -0.643248246659744 0.253309462238708 no 2528 0.260031515898376 3534 20612 SGTC_3098 9119039 49.47 µM -0.644873412128179 0.252769181995533 no 2529 0.25950461149057 3605 17161528 SGTC_144 4161-2749 112.381 µM -0.645285910974327 0.252632144891105 no 2530 0.259370960615995 3525 797501 YMR168C CEP3 SGTC_3175 9106517 49.47 µM -0.645505511410184 0.252559206935992 no 2531 0.25929982391813 3567 41468073 SGTC_1014 4130-3005 69.3 µM -0.64557156436301 0.252537270318989 no 2532 0.259278428897789 3602 743608 SGTC_443 clozapine 122 µM -0.646527262968996 0.25221998894296 no 2533 0.258968973454012 3519 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_3102 9121669 49.47 µM -0.64753677402766 0.251885070864809 no 2534 0.258642301124555 3594 41905072 SGTC_1519 esterone 74 µM -0.647850362066241 0.251781081867876 no 2535 0.258540869174499 3549 698 A steroid. SGTC_119 0121-0043 24.815 µM -0.647990433323838 0.251734640132762 no 2536 0.25849556893491 3667 1092378 SGTC_2345 9052315 157.45 µM -0.648239160554637 0.251652183798292 no 2537 0.258415138559563 3574 6469265 SGTC_836 0330-0104 1.35 µM -0.648485385242958 0.251570571142613 no 2538 0.25833553019792 3605 46494820 SGTC_963 1269-2853 151 µM -0.651803415738845 0.250472155168684 no 2539 0.257263998933168 3579 3668223 SGTC_1658 st012944 20 µM -0.653620177553942 0.249871804572839 no 2540 0.256678270641462 3557 24207260 SGTC_1848 st056003 16.4 µM -0.654942464035577 0.249435334557991 no 2541 0.256252399378109 3652 146492 SGTC_3242 9133940 49.47 µM -0.655857760276866 0.249133444348947 no 2542 0.255957824104854 3645 17248444 SGTC_1534 6-azauridine 81.6 µM -0.658753822647362 0.248179524004574 no 2543 0.255026932253454 3622 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1410 3909-8106 77.9 µM -0.662103706193379 0.247078556048363 no 2544 0.253952380383428 3626 1039210 SGTC_1301 naphtanilide LB 4.81 µM -0.662206018652803 0.24704497134733 no 2545 0.253919598750259 3653 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2446 5162541 200 µM -0.662622953365049 0.246908135194194 no 2546 0.253786032898039 3586 1549321 SGTC_283 0987-0079 11.7 µM -0.663747081671564 0.246539403398218 no 2547 0.253426100068578 3636 411556 SGTC_1512 0259-0544 12.2 µM -0.66483573169482 0.246182590420241 no 2548 0.253077782854401 3617 18476 SGTC_932 2857-0803 154 µM -0.667031251109555 0.245463836160676 no 2549 0.2523760859291 3692 674898 SGTC_925 2064-1272 59.6 µM -0.667140598573307 0.245428068229819 no 2550 0.252341164864967 3590 6815817 SGTC_2007 4011539 71.82 µM -0.667273097996268 0.245384730966865 no 2551 0.252298853434744 3635 45595301 SGTC_2060 5238662 140 µM -0.667622540480025 0.245270456757478 no 2552 0.252187282882184 3597 790130 SGTC_2354 9060492 162 µM -0.668017308982818 0.24514139451847 no 2553 0.252061271875032 3628 6471895 SGTC_2015 5119600 184 µM -0.668938303049558 0.244840434644684 no 2554 0.25176741766717 3623 2828786 SGTC_1225 1216-0074 20.6 µM -0.669145790135589 0.244772660051276 no 2555 0.251701241397301 3623 4241466 SGTC_1853 st056710 91.2 µM -0.669458664962062 0.244670480192203 no 2556 0.251601469961915 3695 269167 SGTC_1774 st048371 48.465 µM -0.669926320271786 0.244517794363122 no 2557 0.251452380140693 3612 4242727 SGTC_3222 9128301 49.47 µM -0.672104935399812 0.24380717047005 no 2558 0.250758447384151 3653 4911358 SGTC_2837 9008476 45.46 µM -0.672953095311325 0.243530818172255 no 2559 0.250488565875711 3646 2992805 SGTC_2200 6600604 21.907 µM -0.672988023836611 0.243519441189464 no 2560 0.250477455042265 3597 2904777 SGTC_1112 tnp00069 1.16933 µM -0.673240541496985 0.243437199218864 no 2561 0.250397136441509 3665 145826 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.673427427286881 0.243376342424581 no 2562 0.250337702241418 3647 5282362 SGTC_2450 5739737 12.93 µM -0.673714871840482 0.243282756096536 no 2563 0.250246302522538 3631 2262825 SGTC_451 chloral hydrate 100 µM -0.674514431985118 0.24302253727688 no 2564 0.249992156770959 3695 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2205 7238770 200 µM -0.675065575192228 0.242843254051153 no 2565 0.249817051846109 3647 279867 SGTC_1978 st071761 42 µM -0.675729969580669 0.242627226147016 no 2566 0.249606052230235 3598 5147680 SGTC_740 k014-0057 261 µM -0.676066827334403 0.242517736579212 no 2567 0.249499108491795 3642 4012779 SGTC_2652 actinonin 100 µM -0.67698766665142 0.242218570896602 no 2568 0.24920688980629 3624 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2322 7413319 38.22 µM -0.679438219432099 0.241423401712516 no 2569 0.248430120163432 3673 1840400 SGTC_878 0828-0289 13.7 µM -0.679664130113002 0.241350168395615 no 2570 0.248358576619528 3644 745350 YLR208W SEC13 SGTC_960 1222-0186 7.7 µM -0.680437466324261 0.241099567905175 no 2571 0.248113752320422 3642 3126296 SGTC_1152 3909-8331 15.9 µM -0.685946048074685 0.239318605257093 no 2572 0.246373565460025 3635 16001939 SGTC_2677 mitomycin C 100 µM -0.686061860617795 0.239281239550292 no 2573 0.246337050076798 3654 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1794 st048918 76.9 µM -0.687566620468215 0.238796034369911 no 2574 0.245862867176407 3590 672303 SGTC_698 k064-0052 127 µM -0.688676068053139 0.238438641387574 no 2575 0.245513569867769 3712 5088751 SGTC_2304 7443016 91.4 µM -0.689199118052917 0.238270249804864 no 2576 0.245348985877572 3616 939854 SGTC_1748 st037455 53.6035 µM -0.689321124621648 0.238230980180222 no 2577 0.245310603570719 3652 580690 SGTC_2493 resveratrol 26.09 µM -0.689465439312312 0.238184534933249 no 2578 0.245265207471333 3590 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_3172 9105863 49.47 µM -0.690295364741697 0.237917533772551 no 2579 0.245004231113594 3630 2348785 SGTC_1757 st041620 31.8375 µM -0.693948728007048 0.236744138044756 no 2580 0.24385718172125 3690 5289815 SGTC_1213 1315-0166 115 µM -0.696550376247227 0.235910478766747 no 2581 0.243042110242882 3644 768401 SGTC_1775 st081588 35.1725 µM -0.697011586808681 0.235762859769684 no 2582 0.24289777130312 3702 1426443 YGL099W LSG1 SGTC_1205 4161-2785 76 µM -0.697137244902984 0.235722649395941 no 2583 0.242858453800571 3674 3498106 SGTC_2234 tolnaftate 200 µM -0.697172682920758 0.235711309975015 no 2584 0.242847366125503 3657 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1240 0356-0016 42.1 µM -0.697842534727729 0.235497028066351 no 2585 0.242637837675578 3664 4305613 SGTC_2311 7694451 200 µM -0.698363615278319 0.235330411621695 no 2586 0.242474912321286 3641 2163142 SGTC_553 k007-0256 45.7 µM -0.698783176277451 0.235196303542101 no 2587 0.242343771988448 3705 6287000 SGTC_1074 carmofur 3.8 µM -0.698848723968624 0.23517535575263 no 2588 0.242323287507186 3701 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_307 1501-1223 22.3 µM -0.70058660959116 0.234620336674918 no 2589 0.241780518683722 3657 2830329 SGTC_2350 9023895 38.85 µM -0.702827518621541 0.233905740262273 no 2590 0.241081622759795 3685 2997209 SGTC_2714 st079313 56.9 µM -0.703921955967167 0.233557177371098 no 2591 0.240740688694519 3674 2939799 SGTC_1729 st035615 45.989 µM -0.704643591930537 0.233327504149331 no 2592 0.240516031614926 3711 17385451 SGTC_1185 1319-0113 81.3 µM -0.705101215075701 0.233181922569122 no 2593 0.240373625216883 3703 4672763 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.70635883394926 0.23278210177267 no 2594 0.23998250716823 3655 641818 YHR062C RPP1 SGTC_2966 9084041 48.03 µM -0.707307622390943 0.232480716285444 no 2595 0.239687664853251 3634 17741380 SGTC_578 3460-0051 92 µM -0.708657367535941 0.232052339876384 no 2596 0.239268563453646 3750 2876744 SGTC_3123 9126162 49.47 µM -0.708806148350143 0.23200514735446 no 2597 0.239222390911699 3764 25239884 SGTC_2138 5575593 77.673 µM -0.709381915622872 0.231822567250804 no 2598 0.239043753552346 3686 762213 SGTC_531 3788-1495 174 µM -0.709813100142752 0.231685887848954 no 2599 0.238910022157758 3666 2896655 SGTC_1612 st002233 45.4 µM -0.71112241566465 0.231271128653121 no 2600 0.238504190275318 3706 1035021 SGTC_1964 st076914 61 µM -0.712176861712172 0.230937407203774 no 2601 0.238177631589616 3724 24208661 SGTC_944 3370-0224 231 µM -0.713516974218451 0.230513663477022 no 2602 0.237762956658368 3722 4580514 SGTC_1455 4262-0120 131 µM -0.713541771878525 0.230505826551292 no 2603 0.23775528717941 3753 1529587 SGTC_1622 st003707 19.4 µM -0.71357070421644 0.230496683111348 no 2604 0.237746339089042 3734 10140899 SGTC_3049 9092223 49.47 µM -0.71395434151421 0.230375462004129 no 2605 0.237627706579069 3665 8623917 SGTC_2875 9039966 71.43 µM -0.714026228299582 0.230352751297231 no 2606 0.237605480577191 3741 6463691 SGTC_402 epigallocatechin gallate 10 µM -0.714088779096554 0.230332991064704 no 2607 0.237586142010317 3677 65064 An antioxidant. SGTC_281 1672-3440 14.9 µM -0.714246384959193 0.230283206477811 no 2608 0.237537419498664 3716 6833000 SGTC_3273 9137859 49.47 µM -0.714727733713234 0.230131195151218 no 2609 0.237388648581989 3758 2377234 SGTC_926 2268-1401 59.4 µM -0.714817205532721 0.230102945880703 no 2610 0.237361001081252 3694 2931578 SGTC_2662 daunorubicin 22.37 µM -0.71602863839226 0.229720646708083 no 2611 0.236986832825571 3601 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3107 9121808 49.47 µM -0.717477523669936 0.229263880745373 no 2612 0.236539750075618 3645 662681 SGTC_2953 9074162 66.49 µM -0.718906973954649 0.22881374119003 no 2613 0.236099119597761 3645 16451992 SGTC_1142 3253-1408 9.78 µM -0.718963760892504 0.228795869010103 no 2614 0.236081624271623 3681 256655 SGTC_2639 lactacystin 53 µM -0.721712483647685 0.227931719083382 no 2615 0.235235632663361 3733 3870 A proteasome inhibitor. SGTC_777 1315-0167 517 µM -0.722447582290421 0.227700928617992 no 2616 0.235009670771035 3723 4221767 SGTC_1906 st060206 94.7 µM -0.724588302282925 0.227029581256281 no 2617 0.234352318690662 3695 5133468 SGTC_2836 9010338 19.48 µM -0.725147303082829 0.22685445796757 no 2618 0.234180833707841 3664 2994051 SGTC_1208 2323-2347 50.3 µM -0.725665537802566 0.226692173932629 no 2619 0.234021916638351 3697 5412760 SGTC_1070 indatraline 8.81 µM -0.726032765515218 0.22657721707404 no 2620 0.233909342152981 3721 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_707 0865-0008 204 µM -0.726549371843836 0.226415554499142 no 2621 0.233751026121518 3704 723043 SGTC_425 3825-7017 13.1 µM -0.726858519899382 0.226318843387839 no 2622 0.233656314902828 3797 3397440 SGTC_1788 fluconazole 20 µM -0.727027065979103 0.22626612677074 no 2623 0.233604687750774 3724 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_772 k072-0172 35.3 µM -0.72875480079386 0.225726138631829 no 2624 0.233075832230083 3729 5861980 SGTC_445 e6 berbamine 66 µM -0.728872953538697 0.225689237693977 no 2625 0.233039690257409 3795 6610268 A calcium/calmodulin antagonist. SGTC_815 1582-0027 36.9 µM -0.729704967000791 0.225429483618717 no 2626 0.232785272181867 3754 3128206 SGTC_3051 9093778 49.47 µM -0.729829384701002 0.225390655043656 no 2627 0.232747240260014 3744 17217378 SGTC_3343 9148379 18.9835 µM -0.730748019438693 0.225104082524906 no 2628 0.232466539485305 3755 1955036 SGTC_2786 7743617 45.45 µM -0.73078445457555 0.225092720666885 no 2629 0.232455410139037 3679 583674 SGTC_2012 4023501 200 µM -0.731128901395311 0.224985325137238 no 2630 0.232350211291934 3724 3477460 SGTC_2113 5491891 107.031 µM -0.731885371527225 0.224749566266349 no 2631 0.232119267775996 3741 789979 SGTC_2923 7992654 58.14 µM -0.73201082624551 0.224710481029739 no 2632 0.232080979936477 3759 2985126 SGTC_2878 9043973 25.97 µM -0.73246817030435 0.224568028793682 no 2633 0.231941431732059 3788 6465167 SGTC_1911 st060208 74.3 µM -0.732577916663255 0.224533852931491 no 2634 0.231907952063795 3767 688783 SGTC_1124 fisetin 1.16336 µM -0.732784807460898 0.224469433568165 no 2635 0.23184484443999 3743 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_263 alizarin 107.927 µM -0.733145753097934 0.224357071430604 no 2636 0.231734768579347 3746 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1907 st060210 83.7 µM -0.733284404216382 0.224313917918299 no 2637 0.231692492554818 3728 688793 SGTC_3237 9133362 49.47 µM -0.733601138305368 0.22421535587737 no 2638 0.231595933489073 3673 43845137 SGTC_978 1416-0512 87.4 µM -0.734988397847571 0.223783955110783 no 2639 0.23117328004829 3785 6814003 SGTC_2183 6420625 130.508 µM -0.735466782938743 0.223635299567595 no 2640 0.2310276313282 3747 2897619 SGTC_2689 tacrolimus 100 µM -0.736920723375393 0.223183840397324 no 2641 0.230585280410979 3749 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_80 0159-0065 512.242 µM -0.737193335315263 0.223099250187518 no 2642 0.230502392912247 3673 1548079 SGTC_2168 5727979 200 µM -0.738154000390546 0.222801305866601 no 2643 0.230210436049658 3677 695210 SGTC_647 0140-0236 81 µM -0.739227225361844 0.222468720086988 no 2644 0.229884515734138 3742 990837 SGTC_1121 fusaric acid 630.51 nM -0.741146221995653 0.22187474119946 no 2645 0.229302393211055 3757 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3209 9113616 49.47 µM -0.741482354742317 0.221770792754747 no 2646 0.229200513359923 3735 16649353 SGTC_3256 9138902 49.47 µM -0.743265806628533 0.221219729101183 no 2647 0.228660384469669 3766 17228773 SGTC_493 zm226600 134 µM -0.743804688785503 0.221053375682409 no 2648 0.228497321565193 3750 5240098 A potassium channel opener. YCR052W RSC6 SGTC_232 clozapine 119 µM -0.744665455543832 0.220787804747955 no 2649 0.2282369936358 3714 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1326 1431-2094 10.8 µM -0.744861043106443 0.220727485927048 no 2650 0.228177863926883 3730 616278 SGTC_2979 9012552 45.46 µM -0.745161455344887 0.220634857764968 no 2651 0.228087060571005 3779 17100905 SGTC_2757 clomiphene 4.22 µM -0.745222653758074 0.22061599076983 no 2652 0.228068565077122 3795 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1933 st074711 15.9 µM -0.745497727466069 0.220531199098196 no 2653 0.227985442225845 3737 17250958 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.7458109375283 0.220434674607728 no 2654 0.227890815933996 3805 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.747075285290752 0.220045276529032 no 2655 0.227509058871821 3763 165506 SGTC_1197 1601-0112 267 µM -0.748190931517655 0.219702004019796 no 2656 0.227172500061911 3755 7350313 SGTC_2308 7584454 197.62 µM -0.749900138570764 0.219176695960787 no 2657 0.226657425517356 3777 893577 SGTC_2768 sulfasalazine 50.2 µM -0.750606204718264 0.218959904371572 no 2658 0.226444842948252 3758 5384001 An antioxidant and salicylic acid derivative. SGTC_1392 3455-1037 33.9 µM -0.750917623782448 0.218864325015153 no 2659 0.226351116612204 3744 981132 SGTC_1022 4477-0945 21.3 µM -0.752875642402858 0.218263928812994 no 2660 0.225762323154043 3731 4648966 SGTC_512 prima-1 270 µM -0.753425830925886 0.218095392936984 no 2661 0.225597032670242 3765 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3301 9125354 19.7965 µM -0.753828617168881 0.217972057470727 no 2662 0.225476068973424 3738 41905162 SGTC_234 nsc-17383 10.7 µM -0.75399292436518 0.217921757211953 no 2663 0.225426735216814 3771 408974 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.75504505237079 0.21759982222164 no 2664 0.225110975334307 3739 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1778 st046819 58.9 µM -0.756471604233046 0.217163757943604 no 2665 0.224683245558469 3809 671715 SGTC_3170 9103054 49.47 µM -0.756575698029199 0.217131958625454 no 2666 0.22465205267958 3755 16432970 SGTC_3263 9137018 49.47 µM -0.75945778680236 0.216252586473283 no 2667 0.22378937838654 3755 43844957 SGTC_1247 0448-0043 5.84 µM -0.761165507184258 0.21573250752487 no 2668 0.2232791088111 3841 3089013 YGL099W LSG1 SGTC_2822 7994718 71.43 µM -0.762399663405156 0.215357102279412 no 2669 0.222910753541073 3738 1018011 SGTC_2911 7942208 15.64 µM -0.762924129238193 0.215197685259711 no 2670 0.222754322518624 3772 1243384 SGTC_1780 st038448 24.544 µM -0.763162155146575 0.215125357333016 no 2671 0.222683347811642 3845 728868 YDL195W SEC31 SGTC_378 3970-0959 8.33 µM -0.763848444885478 0.214916896391877 no 2672 0.222478781704509 3812 6615653 SGTC_679 0422-0091 41.4 µM -0.764906210737663 0.214595829230128 no 2673 0.222163697671733 3780 627384 YHR062C RPP1 SGTC_2210 7115885 190.385 µM -0.765073416146451 0.214545102351455 no 2674 0.222113914360686 3810 2927039 SGTC_2090 5301565 104.445 µM -0.765727580054351 0.214346708703678 no 2675 0.221919206469424 3782 2056344 SGTC_2724 maprotiline 69.64 µM -0.766169867803149 0.214212632954648 no 2676 0.221787617469892 3734 4011 A tricyclic antidepressant. SGTC_78 0336-0123 156.75 µM -0.766591567652238 0.214084843701688 no 2677 0.221662195280132 3650 6765896 SGTC_1876 myriocin 605 nM -0.7670181079009 0.213955632788279 no 2678 0.221535374695754 3795 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1767 st044992 70.3 µM -0.767069261238087 0.213940140068 no 2679 0.221520168374807 3805 9600693 SGTC_1597 7-benzyloxygramine 47.5 µM -0.768055573925567 0.213641545022088 no 2680 0.221227084494403 3761 260807 SGTC_1957 st077035 62.4 µM -0.769368476027079 0.213244455643357 no 2681 0.220837298576737 3821 705593 SGTC_3321 9137793 26.8275 µM -0.769386154350811 0.213239111743834 no 2682 0.220832052765065 3755 4904192 SGTC_1157 4092-0394 27.6 µM -0.769653140046875 0.213158415356485 no 2683 0.220752836922908 3883 3659885 SGTC_825 1988-2224 89.6 µM -0.769703030994376 0.213143337800356 no 2684 0.22073803586198 3778 1180859 SGTC_2731 amoxapine 43.43 µM -0.770210905915988 0.2129898881898 no 2685 0.220587397833634 3834 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1565 sinapyl alcohol 95.1 µM -0.770537553367663 0.212891228818269 no 2686 0.220490543832857 3803 5280507 A phenol propionate derived from cinnamic acid. SGTC_2755 lomerizine 42.69 µM -0.770638870038993 0.212860632930973 no 2687 0.220460507452 3787 3949 A calcium channel blocker. SGTC_2058 5236698 133 µM -0.771675667302764 0.212547685579246 no 2688 0.220153272930814 3790 766665 SGTC_2835 9006588 71.43 µM -0.771714764297756 0.212535889785182 no 2689 0.220141692110328 3844 2345538 SGTC_1847 st056231 15 µM -0.772025044490192 0.212442289980297 no 2690 0.220049797201724 3789 5393180 SGTC_2097 5376186 200 µM -0.774610543648101 0.21166327957145 no 2691 0.219284912568924 3733 742755 SGTC_3206 9114350 49.47 µM -0.775640605847328 0.211353388375586 no 2692 0.21898060890789 3726 17087243 SGTC_2932 9016711 44.54 µM -0.776681802030009 0.211040417796168 no 2693 0.218673263000204 3790 7117328 SGTC_2070 5230947 200 µM -0.777156348372014 0.21089786525753 no 2694 0.218533266263011 3844 2835538 SGTC_2896 9052656 71.43 µM -0.777787752888461 0.210708280481867 no 2695 0.218347074561798 3739 6469436 SGTC_1241 0364-0022 50.8 µM -0.778011735356544 0.210641051800726 no 2696 0.218281047463283 3831 4563895 SGTC_2982 9019404 25.97 µM -0.778851000194768 0.210389257125585 no 2697 0.21803374550971 3747 22333232 SGTC_1632 st005650 90 µM -0.778872532823534 0.210382799272158 no 2698 0.218027402724099 3836 2759605 SGTC_2276 7947513 42.08 µM -0.779069985182679 0.210323586736542 no 2699 0.217969244884267 3683 2105100 SGTC_37 0566-0070 1.56 µM -0.779505851920746 0.21019291251315 no 2700 0.217840895875592 3808 1626686 SGTC_3005 9076496 71.4286 µM -0.78034497157711 0.209941476103243 no 2701 0.217593924375559 3807 21368410 SGTC_1149 3909-7961 23.3 µM -0.780450554063821 0.209909851564719 no 2702 0.217562860560325 3828 735261 SGTC_1732 st034308 51.822 µM -0.780555780168287 0.209878336557213 no 2703 0.217531904144302 3683 830119 SGTC_2705 st078069 42.8 µM -0.780774219253034 0.209812923368514 no 2704 0.217467649774595 3832 1530061 SGTC_2566 crystal violet carbinol 226 nM -0.783990148861277 0.208851277497839 no 2705 0.216522945349625 3823 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_678 1218-2179 85.9 µM -0.78412415036275 0.208811264032006 no 2706 0.216483632962451 3790 6820081 YOR116C RPO31 SGTC_1651 st011928 86.1 µM -0.785268177041911 0.208469836340029 no 2707 0.216148174914983 3808 720198 SGTC_3291 9121177 71.43 µM -0.785672840488401 0.208349145899491 no 2708 0.216029589295207 3816 17015612 SGTC_850 0388-0143 75.9 µM -0.787469087224861 0.207813914967086 no 2709 0.215503658784299 3770 67273 SGTC_2880 9042983 58.44 µM -0.787784128986332 0.207720125169267 no 2710 0.215411493011444 3841 6464714 SGTC_1457 k015-0032 57.3 µM -0.788780064693625 0.207423793728839 no 2711 0.215120281506687 3821 4302660 SGTC_81 0411-0046 9.971 µM -0.789125584148122 0.207321046033505 no 2712 0.215019305075482 3741 12925265 SGTC_1355 1499-0035 1.68 µM -0.790254244678255 0.206985624147483 no 2713 0.214689651212677 3807 1548538 SGTC_2569 tetrandrine 100 µM -0.790292451364222 0.206974275284858 no 2714 0.214678497125317 3839 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.791668700064433 0.206565721790786 no 2715 0.214276938698047 3847 23847180 SGTC_1054 3429-0080 167 µM -0.79221113427506 0.206404825978842 no 2716 0.214118788713293 3807 1162877 SGTC_67 0335-0847 266 µM -0.792899619747561 0.206200715694055 no 2717 0.213918154450126 3985 4552207 YOR254C SEC63 SGTC_1322 1348-1070 12 µM -0.79316481930598 0.20612212584072 no 2718 0.213840900812141 3772 6758089 SGTC_1713 st033146 12.748 µM -0.793268075367941 0.206091531503591 no 2719 0.213810826324007 3778 674619 SGTC_2519 cryptotanshinone 88.04 µM -0.793989826615829 0.205877754844809 no 2720 0.213600676956788 3772 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3339 9145883 14.936 µM -0.794728505303015 0.205659100695211 no 2721 0.213385723559364 3732 2030670 SGTC_3093 9117344 49.47 µM -0.795171310138923 0.2055280934164 no 2722 0.213256929085512 3876 24824913 SGTC_1816 st051957 91.6 µM -0.795305396675453 0.205488432640123 no 2723 0.213217937540281 3810 674121 SGTC_172 1112-0046 2.638 µM -0.796050720224649 0.205268060017905 no 2724 0.213001277803358 3788 2802135 YIL048W NEO1 SGTC_400 oxethazaine 37.5 µM -0.798030218712179 0.204683456282651 no 2725 0.21242647705581 3846 4621 A local anesthetic. SGTC_479 n-linoleoylglycine 10 µM -0.798410199974079 0.204571350131666 no 2726 0.212316243025501 3858 6433346 An anti-infammatory. SGTC_1844 rapamycin 4 nM -0.798947135915921 0.204412999830838 no 2727 0.21216053284632 3768 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3143 9086658 49.47 µM -0.799005046872603 0.204395925398616 no 2728 0.212143742792599 3916 25236626 SGTC_2487 5918373 44.05 µM -0.799030199031479 0.204388509815417 no 2729 0.212136450699538 3840 2876279 SGTC_452 diindolylmethane 8 µM -0.799442189698184 0.204267065860749 no 2730 0.212017027568138 3837 3071 Inhibits expression of several cancer promoting factors. SGTC_3140 9094243 49.47 µM -0.799459069868628 0.204262090949321 no 2731 0.212012135376462 3844 19291112 SGTC_169 k015-0017 16.025 µM -0.799794910292943 0.204163127303934 no 2732 0.211914816212917 3825 1840002 SGTC_3032 9089427 49.47 µM -0.801229796842623 0.203740624432306 no 2733 0.211499312110586 3811 17173707 SGTC_1852 st056254 31.4 µM -0.801275834756473 0.203727077187718 no 2734 0.211485988686435 3764 442583 SGTC_46 0329-0187a 2.197 µM -0.805107434269477 0.202601463341531 no 2735 0.210378843063702 3906 46494817 SGTC_426 0988-0037 14.6 µM -0.806798709509042 0.202105800112764 no 2736 0.209891231383901 3811 5383008 SGTC_360 0957-0399 1.01 µM -0.806921072583341 0.202069967250751 no 2737 0.209855978664631 3868 6752301 YPR165W RHO1 SGTC_3007 9078383 71.4286 µM -0.808651038798455 0.201563770059088 no 2738 0.209357949107941 3831 6496995 SGTC_3224 9130643 49.47 µM -0.810454266661145 0.201036945604579 no 2739 0.208839569780666 3854 17644395 SGTC_2984 9022109 38.96 µM -0.810937786633332 0.200895822730732 no 2740 0.20870069952827 3874 6459207 SGTC_1463 k081-0032 34.1 µM -0.812538721549723 0.200428989214211 no 2741 0.208241288638588 3632 977755 SGTC_333 3486-0131 40.1 µM -0.814957462677294 0.199724920122849 no 2742 0.20754832959705 3919 6744690 SGTC_3057 9095946 49.47 µM -0.815187909831652 0.199657917200664 no 2743 0.207482378646318 3858 24540043 SGTC_163 TUB2.036 7.546 µM -0.816877330769837 0.199167128191231 no 2744 0.206999266932991 3879 15992207 YJR013W GPI14 SGTC_2110 5483698 200 µM -0.817224306755672 0.19906641918382 no 2745 0.206900127128814 3844 2848765 YHR062C RPP1 SGTC_394 menadione 8.33 µM -0.818014590580727 0.198837155614647 no 2746 0.20667442799864 3830 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_60 0986-0278 202 µM -0.818194032284483 0.19878512125154 no 2747 0.206623201112243 3757 3110598 SGTC_930 2810-3379 265 µM -0.819251583316842 0.198478620241081 no 2748 0.206321445004534 3885 1015764 SGTC_1087 pterostilbene 9.05 µM -0.824045302277261 0.197092876413648 no 2749 0.204956908812229 3924 5281727 Similar to reservatol, lowers cholesterol. SGTC_286 k060-0067 22.9 µM -0.825533504001215 0.196663868486311 no 2750 0.204534384735758 3859 5985051 SGTC_2472 5377652 49.4 µM -0.82604482418062 0.19651659949723 no 2751 0.20438933255286 3941 1610903 SGTC_1233 0325-0408 14.2 µM -0.827097671064373 0.196213572051558 no 2752 0.204090852074822 3933 12874 SGTC_1710 st031758 61.5 µM -0.827441136933818 0.196114777988489 no 2753 0.203993536224506 3915 5394341 SGTC_2300 7976697 71.57 µM -0.827797397294547 0.196012335616301 no 2754 0.203892624466345 3777 2236109 SGTC_622 1348-1566 26.3 µM -0.828206899158797 0.19589462380276 no 2755 0.203776668659661 3928 7340407 SGTC_674 0498-0004 451 µM -0.829797044254011 0.195437941453617 no 2756 0.203326771129897 3883 4231473 SGTC_2864 9034755 47.6 µM -0.830713132846345 0.195175138858555 no 2757 0.203067852775913 3841 4930451 SGTC_1085 doxorubicin 7.67 µM -0.832925480202192 0.194541358690709 no 2758 0.202443379143093 3876 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2170 morpholine 200 µM -0.833758837802457 0.194302948468963 no 2759 0.202208447469065 3912 121171 Reacts with secondary amines. SGTC_2679 rapamycin 1 nM -0.835532368132237 0.193796162466562 no 2760 0.20170901511507 3837 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1789 tunicamycin 25 nM -0.836937089882119 0.193395335867907 no 2761 0.201313965367401 3812 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1258 0671-0043 57.1 µM -0.837002769361971 0.193376607117304 no 2762 0.201295505691338 3919 4298767 SGTC_492 tmb-8 126 µM -0.838591862456292 0.192923808607722 no 2763 0.200849189336786 3822 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1510 1123-0200 71.5 µM -0.840961679107619 0.192249753708323 no 2764 0.200184701379996 3945 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1667 st014849 34.6 µM -0.841411025828792 0.192122107169191 no 2765 0.20005885536935 3925 5348460 SGTC_3185 9108267 49.47 µM -0.84326775120923 0.19159521467435 no 2766 0.199539357209012 3871 4910486 SGTC_2922 7999257 32.47 µM -0.84494827168772 0.191119088655792 no 2767 0.199069860589463 3865 2988377 SGTC_1056 3448-1962 115 µM -0.845389222189695 0.190994278568751 no 2768 0.198946780043313 3893 715507 SGTC_250 brefeldin a 552.239 µM -0.845400089100306 0.1909912033445 no 2769 0.198943747390194 3768 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1306 1185-0270 9.02 µM -0.845930183543904 0.190841228929403 no 2770 0.198795846574007 3925 1548076 SGTC_1564 D-Arginine 115 µM -0.845996563334349 0.190822453839009 no 2771 0.198777330724387 3907 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_285 1486-1325 46 µM -0.846048447710969 0.190807779470944 no 2772 0.198762858921276 3923 22310230 SGTC_1273 0849-0096 14.1 µM -0.846065585963102 0.190802932441016 no 2773 0.198758078789277 3918 5286025 SGTC_3169 9102970 49.47 µM -0.846777041174144 0.190601785787617 no 2774 0.198559703744159 3969 17027839 SGTC_2282 7944268 200 µM -0.846806870769335 0.190593355039519 no 2775 0.198551388968048 3900 2970414 SGTC_2627 acetyl isogambogic acid 100 µM -0.847025575173096 0.190531549535762 no 2776 0.198490433169629 3910 6857789 A caspase activator and apoptosis inducer. SGTC_529 4076-0302 30.3 µM -0.848423319757849 0.190136839914197 no 2777 0.19810113004529 3855 5816522 SGTC_1670 st016595 4.04 µM -0.848723115571765 0.190052245949626 no 2778 0.198017690293538 3898 597879 SGTC_2991 9074669 71.4286 µM -0.849028336282558 0.189966144998753 no 2779 0.197932762481668 3876 17333109 SGTC_327 1273-0057 3.96 µM -0.851440288849144 0.18928659122594 no 2780 0.197262409710097 3799 3108138 SGTC_1170 0310-0127 64.8 µM -0.852166773710872 0.189082201915314 no 2781 0.19706076758296 3916 774975 SGTC_744 1594-0068 283 µM -0.852552945046317 0.188973611791366 no 2782 0.196953633201781 3911 668392 SGTC_6 0844-0013 19.835 µM -0.852676323566025 0.188938926252303 no 2783 0.196919412094174 4017 1584900 SGTC_1707 st032323 6.317 µM -0.853752365045019 0.188636583827465 no 2784 0.196621106518084 3791 3132057 YMR211W DML1 SGTC_98 0074-0023 107.663 µM -0.854039820001516 0.188555866234435 no 2785 0.196541463181643 3891 3563821 SGTC_2702 st077768 96.8 µM -0.854230440466894 0.188502351593353 no 2786 0.196488659948905 3895 6484119 SGTC_912 3474-0017 2.18 µM -0.854487789521045 0.188430118479787 no 2787 0.196417386058412 3956 3360550 SGTC_2236 dapsone 200 µM -0.855554488462718 0.188130897911207 no 2788 0.196122126467831 3910 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2119 5528445 120.635 µM -0.855715818495966 0.188085668638221 no 2789 0.19607749416519 3926 791935 SGTC_2290 7904846 200 µM -0.856005719283575 0.188004411104475 no 2790 0.195997307968357 3975 2962154 SGTC_222 nsc-310342 10.666 µM -0.856862556992109 0.187764371103382 no 2791 0.195760424039095 3854 432556 SGTC_2884 9058502 51.95 µM -0.857205942242431 0.187668226116712 no 2792 0.195665539515737 3937 6471554 SGTC_810 3825-7150 143 µM -0.857916569308021 0.187469353124659 no 2793 0.195469267098372 3964 22330411 YGL099W LSG1 SGTC_803 4488-1585 147 µM -0.858365926903069 0.187343665114675 no 2794 0.19534521802256 3935 747204 SGTC_1442 4112-3290 3 µM -0.859751380962983 0.186956473342106 no 2795 0.194963052520449 3893 704353 SGTC_1985 st071382 65.5 µM -0.860261653376706 0.18681399275448 no 2796 0.194822412920863 3918 6123237 SGTC_1352 1496-0991 99 µM -0.861235193770087 0.186542342854717 no 2797 0.194554260152552 3909 3000039 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.862177349588791 0.186279683332875 no 2798 0.194294965963676 3936 2374 Ca(2+)-ATPase inhibitor. SGTC_3161 9100388 49.47 µM -0.862819938940785 0.186100670157573 no 2799 0.194118237335297 3962 25236368 SGTC_2778 tioconazole 65.09 nM -0.863263576462464 0.185977143423647 no 2800 0.193996282745176 3836 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2152 5568786 200 µM -0.863542654222963 0.185899462876734 no 2801 0.193919589054085 3874 5399883 SGTC_1619 st003326 88.7 µM -0.864109816227978 0.185741656859434 no 2802 0.193763783533421 3901 2849032 SGTC_2379 9035213 200 µM -0.864310116439164 0.185685945592584 no 2803 0.193708777145064 3881 646551 SGTC_1139 k015-0024 46.9 µM -0.866645086374814 0.185037264826958 no 2804 0.193068250984154 3896 2766652 SGTC_1819 st053448 58.6 µM -0.866733083335364 0.185012845847386 no 2805 0.193044137076467 3841 2857616 SGTC_590 k048-0076 22.4 µM -0.868996171630108 0.184385531406049 no 2806 0.192424612377259 3938 6832814 SGTC_3099 9120367 49.47 µM -0.870353031446418 0.184010053343782 no 2807 0.192053753041357 3944 24824940 SGTC_1393 3470-5649 58.2 µM -0.870664093128679 0.183924041690053 no 2808 0.191968794778127 3904 4108395 SGTC_108 0509-0257 621.132 µM -0.871254270933775 0.183760920476048 no 2809 0.191807666570142 3901 536624 SGTC_619 1652-1634 108 µM -0.871828939004909 0.183602172680408 no 2810 0.191650852366947 3898 5400454 SGTC_3070 9117005 49.47 µM -0.873104744170146 0.183250046543974 no 2811 0.19130299413539 3967 8779016 SGTC_322 k048-0136 19.3 µM -0.873982524448247 0.183008021232241 no 2812 0.191063885371309 3995 6823282 SGTC_2287 7945887 168.79 µM -0.874527010803812 0.182857993415171 no 2813 0.190915658554305 3956 1245853 SGTC_145 3737-0113 38.366 µM -0.879125183695288 0.181594075737807 no 2814 0.189666702197761 3920 6849351 SGTC_2869 9037858 32.47 µM -0.881289239904967 0.181001129828502 no 2815 0.18908064425125 3889 27187042 SGTC_2268 7933382 153.85 µM -0.881658627512161 0.180900039907481 no 2816 0.188980720257314 3958 935025 YOR257W CDC31 SGTC_1460 k062-0059 9.15 µM -0.882480884440277 0.180675140792636 no 2817 0.188758406246814 3842 1373085 SGTC_655 k060-0012 42 µM -0.88296930214693 0.180541634548364 no 2818 0.188626428850824 3939 5994525 SGTC_2649 anisomycin 9.56 µM -0.887413303767355 0.179329735809698 no 2819 0.18742821174877 3938 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2969 9091408 28.7 µM -0.887853542012804 0.179209960005768 no 2820 0.187309768851403 3910 4286311 SGTC_1975 st070967 30.8 µM -0.888384824941548 0.179065480654433 no 2821 0.187166892679538 3904 261391 SGTC_2712 st079126 47.7 µM -0.88867402164399 0.17898686607755 no 2822 0.18708914829795 3944 3152970 SGTC_1044 1222-0021 1.78 µM -0.890222150383056 0.17856639566603 no 2823 0.186673306575683 3938 4306703 SGTC_455 paf C-16 10 µM -0.890751018773341 0.178422898148412 no 2824 0.186531378858086 3926 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_3290 9121031 71.43 µM -0.89282543062204 0.177860750913107 no 2825 0.18597533272871 3976 17014854 SGTC_515 4092-1064 102 µM -0.89343758037991 0.177695077448339 no 2826 0.185811442564086 3978 717353 SGTC_3087 9117406 49.47 µM -0.897434484886106 0.176615741650565 no 2827 0.184743559035803 3990 42546093 SGTC_2074 5212007 75.395 µM -0.899137788562233 0.176157039034444 no 2828 0.184289636101754 3809 758611 SGTC_2643 anethole 100 µM -0.900050498760199 0.17591155518113 no 2829 0.184046688676881 3973 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1857 st056007 79.3 µM -0.900161544435886 0.175881702965265 no 2830 0.184017143879967 3962 619834 SGTC_324 1315-0088 19.6 µM -0.901234743378421 0.175593362116656 no 2831 0.183731760914217 3932 6787421 SGTC_1336 1486-0901 104 µM -0.9020246232973 0.175381333259865 no 2832 0.183521893839769 3992 5006114 SGTC_2607 solasodine 47.35 µM -0.903279203225601 0.175044897960006 no 2833 0.18318886559902 3981 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2403 6032726 181.2 µM -0.90387442156358 0.174885424125394 no 2834 0.183030996811549 4032 2881040 SGTC_2271 7849410 118.62 µM -0.90396141974002 0.174862122870238 no 2835 0.183007929539441 3868 972430 SGTC_277 nystatin 15.5 µM -0.905101028480023 0.174557076441954 no 2836 0.182705933663573 3961 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1481 3346-2004 36 µM -0.905966661370931 0.174325592883216 no 2837 0.18247674933817 3998 2770522 SGTC_3029 9088683 49.47 µM -0.906355243935575 0.174221743381853 no 2838 0.182373926930938 4006 25236615 SGTC_1730 st033808 45.1 µM -0.906961674947314 0.17405975200143 no 2839 0.182213532230251 3931 1045166 SGTC_2013 4024628 200 µM -0.909543259619553 0.173371224457769 no 2840 0.181531716896587 4027 5230760 SGTC_2182 6325192 200 µM -0.909885449822684 0.173280090143392 no 2841 0.181441461978087 3897 736248 SGTC_2812 7970281 58.44 µM -0.910391049309785 0.17314549144999 no 2842 0.181308158212374 4041 2233435 SGTC_1677 st019204 53.9 µM -0.911313043167574 0.172900213380939 no 2843 0.181065227978822 4006 3945625 SGTC_1711 st032263 62.8 µM -0.911771397142776 0.172778359887454 no 2844 0.180944535162084 3976 3958979 SGTC_620 0109-0052 432 µM -0.914370870161886 0.172088325325341 no 2845 0.180261001440942 3985 493037 SGTC_1107 amlodipine 47 µM -0.915615928209424 0.171758446419002 no 2846 0.179934187040065 3751 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_279 1273-0055 2.93 µM -0.916902659192545 0.171417950931456 no 2847 0.179596825198391 3994 2847562 SGTC_2414 st077232 92.9 µM -0.916952167739665 0.171404858576506 no 2848 0.179583852735784 3957 729801 SGTC_1422 4031-0024 15.5 µM -0.917523142878603 0.171253912473739 no 2849 0.179434285702475 3947 782427 SGTC_2023 5144124 124 µM -0.918195222340761 0.171076346813438 no 2850 0.179258334745075 3983 2830192 SGTC_5 0352-0601 109.883 µM -0.919187045482842 0.17081451899615 no 2851 0.178998872923739 3917 762456 SGTC_3304 9125678 46.087 µM -0.919661884396331 0.170689258804692 no 2852 0.178874738330165 3929 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1467 k284-1082 293 µM -0.920336019343774 0.170511526310159 no 2853 0.178698595933867 3956 3334705 SGTC_2079 5212404 121 µM -0.922808433517754 0.169860700737685 no 2854 0.17805352254288 3954 758462 SGTC_237 nikkomycin 200 µM -0.923044392712992 0.169798671421766 no 2855 0.177992035665693 4016 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2817 7995342 71.43 µM -0.926457105367576 0.168903156959606 no 2856 0.177104239497342 4008 18879975 SGTC_1880 MG-132 525 µM -0.928973274596258 0.168244847226901 no 2857 0.176451468372603 3956 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2776 terbinafine 19.92 µM -0.929699063957352 0.168055264820349 no 2858 0.176263459634215 4028 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1237 0330-0133 46.1 µM -0.931377440620235 0.167617385198613 no 2859 0.175829178080633 3939 X1237 YHR072W ERG7 SGTC_2929 9013348 24.6 µM -0.935480286733674 0.166550071239703 no 2860 0.174770418981004 4041 2995952 SGTC_2455 5377712 9.75 µM -0.93554676224896 0.166532814498703 no 2861 0.17475329803925 4008 2243908 SGTC_2598 perillyl alcohol 100 µM -0.93564260088206 0.166507937257631 no 2862 0.174728616424247 4055 10819 An apoptosis inducer. SGTC_3246 9135460 32.98 µM -0.93597047619034 0.166422847414739 no 2863 0.174644194434822 3951 41446951 SGTC_189 3970-0742 2.116 µM -0.937449568642442 0.166039344016227 no 2864 0.174263676773161 3956 2891807 SGTC_132 0417-1715 25.805 µM -0.938052155232669 0.165883267448281 no 2865 0.17410880391681 3963 6769098 SGTC_706 4262-0057 46.9 µM -0.938107367120673 0.165868971704604 no 2866 0.174094618095874 3991 883298 SGTC_1484 3473-2379 286 µM -0.939519543447235 0.165503594485097 no 2867 0.173732031477695 4131 671917 SGTC_2546 rhodinyl acetate 100 µM -0.939902673571164 0.165404555765969 no 2868 0.173633742915627 3948 6708682 SGTC_1250 0485-0349 40.2 µM -0.941637161677148 0.164956672309443 no 2869 0.17318921847299 4026 6842794 YDL195W SEC31 SGTC_1986 st071812 45 µM -0.941823664331284 0.164908559975937 no 2870 0.173141463708038 3946 11838594 SGTC_1202 1988-0068 29.6 µM -0.941917499660794 0.164884356590067 no 2871 0.173117439960966 3982 2850480 SGTC_3010 9080089 71.4286 µM -0.942054413016261 0.164849046014789 no 2872 0.173082391174861 4040 17027233 SGTC_2916 7875993 68.79 µM -0.942986649333735 0.164608748260623 no 2873 0.172843865888073 3888 1299250 SGTC_137 0438-0332 85.389 µM -0.943767338133108 0.164407688849717 no 2874 0.172644277338779 4004 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_610 4215-0184 155 µM -0.944171050832786 0.164303778734295 no 2875 0.17254112302784 4049 5605015 SGTC_345 1362-0200 395 µM -0.944828399459714 0.16413467734392 no 2876 0.172373245265106 4023 1419823 SGTC_1553 gossypol 38.6 µM -0.946531026689362 0.163697205538405 no 2877 0.171938902431924 3882 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_736 0958-0254 92.6 µM -0.950570753977889 0.162662272428177 no 2878 0.170911160404243 4122 6812352 SGTC_3008 9078912 71.4286 µM -0.953203795790547 0.161990012737451 no 2879 0.170243411782986 4015 16648731 SGTC_3234 9132280 49.47 µM -0.953616962108181 0.161884688959174 no 2880 0.17013878328008 4069 17612295 SGTC_2688 kanamycin b 96.69 µM -0.958030341028396 0.160762420995946 no 2881 0.16902372958434 4117 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1395 3486-0190 4.35 µM -0.958420034601349 0.160663571386463 no 2882 0.168925498330601 4019 6748079 SGTC_918 glabranin 770.725 nM -0.95845876358719 0.160653749567123 no 2883 0.168915737800294 4046 124049 Also referred to as licorice root. SGTC_2467 5474540 200 µM -0.958726468868905 0.160585869204866 no 2884 0.168848280268253 3996 5413519 SGTC_122 0236-0016 402.397 µM -0.959266543777863 0.16044898280172 no 2885 0.168712242552844 4034 6808838 SGTC_788 1182-0090 188 µM -0.960443812216371 0.160150858786311 no 2886 0.168415948426143 4097 5715185 SGTC_2956 9076196 2.52 µM -0.966703576067649 0.158571761802374 no 2887 0.166846119453262 4077 16423868 SGTC_2451 5856223 45.7 µM -0.971720646740377 0.157313544792463 no 2888 0.165594771194787 4032 2179896 SGTC_2195 6536160 144.242 µM -0.972792683722356 0.157045545037793 no 2889 0.165328174824777 4004 3834386 SGTC_2630 antimycin a 100 µM -0.973179175324667 0.156948999251366 no 2890 0.165232129443904 4012 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1394 3474-0001 65.7 µM -0.97365562162763 0.156830036485312 no 2891 0.165113779510094 4044 5017666 YIL048W NEO1 SGTC_868 0527-0199 213 µM -0.97389451632646 0.156770409765116 no 2892 0.16505445839065 4010 2849450 SGTC_2081 5214970 32.255 µM -0.976647703884031 0.156084307115199 no 2893 0.164371796833023 4004 2063512 SGTC_2897 9048598 12.99 µM -0.978454148915029 0.155635212259256 no 2894 0.163924879037273 4048 6467404 SGTC_1864 st057645 30.4 µM -0.978780339349406 0.155554209969112 no 2895 0.163844263050516 4098 688666 SGTC_503 tyrphostin 8 294 µM -0.980838939411156 0.155043643175327 no 2896 0.163336086237513 4067 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2894 9048625 32.47 µM -0.981175876774535 0.154960182646814 no 2897 0.163253009000045 4048 4092861 SGTC_1545 lovastatin 49.4 µM -0.982121548393274 0.154726095108718 no 2898 0.163019985396617 4132 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_236 1509-0011 5.31 µM -0.985231767086587 0.153957853456956 no 2899 0.162255119980009 4122 3107280 SGTC_2335 9018011 154.17 µM -0.98556010762687 0.153876899031142 no 2900 0.162174510989155 4074 6458208 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.986996083857361 0.153523181136832 no 2901 0.161822279210755 4089 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2395 5646831 180.19 µM -0.988407857500159 0.15317595032025 no 2902 0.16147647042883 4107 6808628 SGTC_480 am 92016 50 µM -0.988420008364939 0.153172964032065 no 2903 0.161473496211988 4045 2129 K+ channel blocker. SGTC_1509 1326-1131 80 µM -0.988756938170382 0.153090172989722 no 2904 0.161391038754118 4011 768313 SGTC_3053 9095903 49.47 µM -0.989080038267349 0.153010808074711 no 2905 0.161311991664068 4172 17174018 SGTC_168 3970-0862 530.542 µM -0.989481187279377 0.152912309521803 no 2906 0.16121388489552 4052 3135186 SGTC_1653 st012112 65 µM -0.991014868305028 0.152536115570119 no 2907 0.160839160087767 4071 720429 SGTC_1672 st016598 6.51 µM -0.994887956226475 0.151588828343313 no 2908 0.159895380562774 4105 4665860 YNL267W PIK1 SGTC_1716 st033144 30.6155 µM -0.998413058854873 0.150730058517504 no 2909 0.159039551917367 4104 674617 SGTC_2520 obtusaquinone 4.71 µM -0.998942891008094 0.150601263747121 no 2910 0.158911178558752 4147 5967872 SGTC_1283 0922-0125 16.4 µM -1.00053479131981 0.150214736145097 no 2911 0.158525884690361 4093 3360884 SGTC_36 0335-0881 14.2 µM -1.00200982853502 0.149857174628039 no 2912 0.158169422973923 3994 23828853 SGTC_2148 5546263 113.568 µM -1.0026532675207 0.149701377533036 no 2913 0.158014092582337 4070 792097 SGTC_1881 5652484 16 µM -1.00450106998912 0.149254566580615 no 2914 0.15756857787561 4076 2255129 SGTC_1518 st038567 90.8 µM -1.00571802101877 0.148960786553401 no 2915 0.157275615930095 4049 77966 SGTC_2525 harmine 47.85 µM -1.0073016061434 0.148579077456051 no 2916 0.156894929092892 4079 5280953 A monoamine oxidase inhibitor SGTC_2314 7727897 200 µM -1.01036474978325 0.147842591354365 no 2917 0.156160284904821 4117 900724 SGTC_228 caffeine 993.056 µM -1.01336684460868 0.147123159056153 no 2918 0.15544248497632 4105 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_844 0330-0132 15.3 µM -1.0205880491327 0.145402272117619 no 2919 0.153724826954019 4160 2828079 SGTC_308 4092-1169 104 µM -1.02109943453055 0.145280919224402 no 2920 0.153603665497953 4041 2268590 YDL196W YDL196W SGTC_2352 9027995 87.8 µM -1.02226016117837 0.14500572913161 no 2921 0.15332889170912 4070 2997347 SGTC_2683 piperine 63.03 µM -1.02258918584734 0.144927786411393 no 2922 0.153251062399535 4093 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1820 st053765 18.6 µM -1.02340402708446 0.144734879948814 no 2923 0.153058428068708 4173 3690829 SGTC_275 trichlorophene 5.69 µM -1.02534369414365 0.144276376962185 no 2924 0.152600522862323 4164 62616 SGTC_1854 st056233 32.9 µM -1.02553324295561 0.144231623547947 no 2925 0.15255582409097 4033 5393174 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.02630257268045 0.14405007706769 no 2926 0.152374492501757 4137 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_995 3931-2021 34.6 µM -1.02804774179318 0.143638823428566 no 2927 0.151963685379824 4120 730143 SGTC_796 1234-0020 70.7 µM -1.02906407722578 0.14339968679625 no 2928 0.151724782630234 4053 46495034 SGTC_301 4119-0100 24.5 µM -1.02973814656557 0.14324123133428 no 2929 0.151566471681812 4137 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1989 st071868 50.2 µM -1.03178483771338 0.142760834492915 no 2930 0.151086461870112 4106 16414057 SGTC_1607 st000305 50.6 µM -1.03206017082317 0.142696291853529 no 2931 0.151021965360194 4142 5457690 SGTC_829 1635-0120 117 µM -1.03616213588272 0.141737059617071 no 2932 0.150063254050053 4139 285054 SGTC_3223 9129970 49.47 µM -1.03675798449421 0.141598086335886 no 2933 0.14992433055769 4154 17248386 SGTC_3000 9075062 71.4286 µM -1.03699981203108 0.141541709820492 no 2934 0.149867972379799 4079 17057871 SGTC_1253 0550-0034 176 µM -1.04168848235828 0.140451660108163 no 2935 0.14877806530288 4169 5969915 SGTC_692 k241-0027 77.8 µM -1.04452028572082 0.139796073600301 no 2936 0.148122369388389 4199 3600480 SGTC_2791 5663188 71.43 µM -1.04458840119167 0.139780329952748 no 2937 0.148106621300653 4183 54690634 SGTC_2942 9052777 62.25 µM -1.04808719798426 0.138973267706908 no 2938 0.147299217000311 4212 6469503 SGTC_3311 9131146 2.8755 µM -1.04858919956792 0.138857732521044 no 2939 0.147183614422807 4116 4900406 YPR165W RHO1 SGTC_508 roscovitine 141 µM -1.04961885225045 0.13862096364709 no 2940 0.146946692969495 4216 160355 A CDKinase inhibitor. SGTC_2496 diffractaic acid 79.83 µM -1.05015588777924 0.13849758140164 no 2941 0.146823223492325 4167 94870 An apoptosis inducer which activates caspases. SGTC_2374 9071832 200 µM -1.05067544950655 0.138378284948648 no 2942 0.14670383765798 4068 17381698 SGTC_2349 9023730 187.07 µM -1.05105099350875 0.138292099993144 no 2943 0.146617585044252 4170 4126287 SGTC_2355 9061122 103.12 µM -1.05228812796919 0.138008444372652 no 2944 0.146333688438855 4160 5302957 SGTC_1873 rapamycin 2 nM -1.05236206996883 0.137991503203085 no 2945 0.146316731986912 4106 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_32 0928-0142 34.1 µM -1.05257100001341 0.13794364200851 no 2946 0.146268827074997 4132 2244242 SGTC_2787 5284540 71.43 µM -1.05261638527059 0.137933246759646 no 2947 0.146258422224966 4195 736958 SGTC_289 k017-0060 526 µM -1.0547371289468 0.137448097651596 no 2948 0.145772782894489 4128 5512909 SGTC_3228 9131799 49.47 µM -1.05604280641773 0.137149986210033 no 2949 0.14547432919721 4141 17015818 SGTC_3147 9097027 49.47 µM -1.06090940498878 0.136042740656992 no 2950 0.144365537346136 4145 25236841 SGTC_2049 5262831 67.185 µM -1.06113710613087 0.1359910845107 no 2951 0.144313798427247 4151 763417 SGTC_2936 9038235 15.59 µM -1.06458932034773 0.135209562155367 no 2952 0.143530907384828 4093 4749415 SGTC_1764 st044502 93.5 µM -1.06559682812471 0.134982061203894 no 2953 0.143302966833092 4199 8407 SGTC_458 nppb 133 µM -1.06651943700169 0.13477396132232 no 2954 0.143094448515109 4198 4549 A chloride channel blocker. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.06658115084516 0.134760049259588 no 2955 0.143080507921672 4198 6708561 SGTC_1123 mangostin 811.285 nM -1.06687374422641 0.134694103766681 no 2956 0.14301442623778 4172 5281650 An antioxidant. SGTC_2603 homopterocarpin 100 µM -1.07045137594257 0.133889558127471 no 2957 0.142208092246778 4150 101795 A weak amylase inhibitor. SGTC_3348 9149464 3.537 µM -1.07223429323293 0.133489847361881 no 2958 0.141807405484488 4113 1951442 SGTC_143 4032-1194 15.74 µM -1.0724141725024 0.133449566001896 no 2959 0.141767022531609 4179 1806963 SGTC_2833 9001315 45.46 µM -1.07309118715608 0.133298033319468 no 2960 0.141615102354649 4128 2989378 SGTC_1896 st058441 89 µM -1.07373079082228 0.133154982936341 no 2961 0.141471678450952 4173 688759 SGTC_997 3996-0078 137 µM -1.07399095640649 0.133096825911937 no 2962 0.141413367426745 4217 735687 SGTC_778 3456-2434 196 µM -1.07614207143023 0.132616638753916 no 2963 0.14093186123303 4130 5539063 SGTC_1028 k015-0029 4.8 µM -1.07655871165511 0.132523771500913 no 2964 0.140838729081883 4113 4588309 SGTC_1066 ketoconazole 628 nM -1.07739757375246 0.132336928821772 no 2965 0.140651343797976 4228 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_546 peri-Naphthalide 147 µM -1.07761376961833 0.132288804203797 no 2966 0.140603077332928 4098 223824 A penicillin ester. SGTC_3046 9092212 49.47 µM -1.07903379743396 0.131973009669917 no 2967 0.140286330719256 4232 25236637 SGTC_468 gf-109203x 121 µM -1.08050564267949 0.131646240796844 no 2968 0.13995853771675 4150 2396 A protein kinase C inhibitor. SGTC_2556 citropten 84.59 µM -1.08169298470397 0.131383042576059 no 2969 0.139694485702154 4209 2775 A potential DNA crosslinker. SGTC_530 4358-1714 28 µM -1.08373167578155 0.130931973668879 no 2970 0.139241893386935 4178 1564641 SGTC_181 1447-1644 8.07 µM -1.08431043632309 0.130804115734509 no 2971 0.139113589769825 4172 534600 SGTC_693 4161-2696 114 µM -1.08488158141834 0.130678024807877 no 2972 0.138987053307976 4208 805759 SGTC_929 2805-0021 398 µM -1.08525514870844 0.130595598334166 no 2973 0.138904332354383 4243 3098024 SGTC_2470 5664817 21.68 µM -1.0858827317473 0.130457205007105 no 2974 0.13876543884738 4209 2859561 SGTC_1150 3909-7983 10.9 µM -1.08589562766262 0.130454362290196 no 2975 0.138762585780738 4157 23965914 SGTC_1230 0170-0365 3.77 µM -1.08638658033816 0.130346170776689 no 2976 0.138653998100543 4235 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1470 k295-0292 231 µM -1.08694947032104 0.13022220279665 no 2977 0.138529570756036 4264 5045612 SGTC_661 1304-0007 33.6 µM -1.08703371578115 0.130203656032749 no 2978 0.138510954767931 4185 3117130 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.09206978535893 0.129098276929201 no 2979 0.137401214396762 4119 4330530 SGTC_1245 0418-0076 17.2 µM -1.09519401922131 0.128415810606286 no 2980 0.136715822665171 4236 6790114 SGTC_1505 k297-0037 20.6 µM -1.09653348430992 0.128123982568301 no 2981 0.136422689080281 4195 4089396 SGTC_3312 9133330 71.43 µM -1.09775074361728 0.127859179183454 no 2982 0.136156672613645 4234 17617324 SGTC_1878 temozolomide 1 mM -1.09913630262391 0.127558226881056 no 2983 0.135854308686497 4114 5394 DNA alkylating agent. SGTC_1226 3909-7979 35.4 µM -1.10255614370308 0.126817524652587 no 2984 0.135109982227618 4183 6615510 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.10735565410039 0.12578305893602 no 2985 0.134070095468529 4201 1377 SGTC_399 oxolinic acid 75 µM -1.10854276880121 0.125528103892166 no 2986 0.133813739553148 4175 4628 A DNA gyrase inhibitor. SGTC_2522 biochanin a 4.94 µM -1.10983260072423 0.125251497448559 no 2987 0.133535584133938 4214 5280373 A possible chelator. SGTC_2317 5986382 200 µM -1.11007546395249 0.125199462700441 no 2988 0.133483254599241 4229 877883 SGTC_676 falcarinol 140 µM -1.11033069903874 0.125144793485334 no 2989 0.133428274512872 4239 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1227 3909-8010 46.6 µM -1.11116438431354 0.124966341254515 no 2990 0.133248799250258 4187 15982272 SGTC_1425 4048-4433 7.33 µM -1.11535039051446 0.12407300445702 no 2991 0.132350149804385 4265 23734946 SGTC_1916 st067606 49.2 µM -1.11749607627 0.123616829344574 no 2992 0.131891138161338 4139 19590279 SGTC_2433 5607874 27.82 µM -1.11835618775983 0.123434298884724 no 2993 0.131707449167552 4177 2252428 SGTC_2277 7947813 106.88 µM -1.11851201584514 0.123401249695015 no 2994 0.131674188769907 4267 1246798 SGTC_346 4513-0042 7.16 µM -1.11935272756371 0.123223052186627 no 2995 0.131494844820872 4182 2827372 SGTC_3227 9130768 49.47 µM -1.12014049043258 0.123056241452762 no 2996 0.131326949221167 4266 17720899 SGTC_2766 oltipraz 83.91 µM -1.12133046067834 0.122804562577707 no 2997 0.131073612108975 4193 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2187 6125751 200 µM -1.12467683947816 0.122098738705146 no 2998 0.130362999750897 4220 874498 SGTC_1122 capsaicin 818.572 nM -1.12703921177193 0.121602181589115 no 2999 0.129862951305541 4275 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2684 capsaicin 100 µM -1.12910807032289 0.121168486566839 no 3000 0.129426123641828 4239 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_226 1,3-diallylurea 8.28947 mM -1.13079047867204 0.120816606124581 no 3001 0.129071644181311 4151 74537 YKL182W FAS1 SGTC_2047 4141938 200 µM -1.13205079336339 0.120553479376055 no 3002 0.128806540266275 4227 3807862 SGTC_2842 9000675 19.48 µM -1.13249160929903 0.120461541760329 no 3003 0.128713905006786 4282 2989072 SGTC_1092 toremifene 6.32 µM -1.13399219418698 0.120148946408578 no 3004 0.128398911153291 4203 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_962 1254-0300 21.5 µM -1.13505712446831 0.119927451792586 no 3005 0.128175692233833 4192 7340576 SGTC_1608 st001473 40.5 µM -1.13607140706869 0.119716759160069 no 3006 0.127963340245055 4179 7292267 SGTC_2727 riluzole 51.77 µM -1.13892402549593 0.119125596683926 no 3007 0.12736742190935 4266 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2481 5478948 45.16 µM -1.14167399846549 0.118557659709505 no 3008 0.126794776321848 4259 77792 SGTC_1955 wogonin 32.4 µM -1.1440049245044 0.118077766686214 no 3009 0.126310797365131 4298 5281703 A flavanone. SGTC_326 k292-0812 17.5 µM -1.14692187344886 0.11747916036169 no 3010 0.125706955805399 4228 3579357 SGTC_61 0978-8327 98.565 µM -1.14727124766064 0.117407607324414 no 3011 0.125634766652583 4159 6150059 YHR072W ERG7 SGTC_1590 st077108 57.8 µM -1.14800166863513 0.11725811431957 no 3012 0.125483937493557 4254 5489485 SGTC_804 1595-0054 20.9 µM -1.14804435086049 0.117249382851716 no 3013 0.125475127685817 4179 761523 Stimulates phospholipase C. SGTC_1199 1638-0010 4.46 µM -1.14833745628254 0.117189434956002 no 3014 0.125414641038271 4212 3111136 SGTC_92 0063-0024 660.874 µM -1.15075275995574 0.116696267348143 no 3015 0.124916982154534 4329 3594437 SGTC_896 0964-0007 44.5 µM -1.15416536846376 0.116001976673922 no 3016 0.124216188899504 4209 6756758 SGTC_1443 4112-3303 14 µM -1.15460482200964 0.115912784004145 no 3017 0.124126145568569 4290 704433 SGTC_970 1315-0089 19.5 µM -1.15609619265542 0.11561045447844 no 3018 0.123820906600095 4200 6811083 YLR033W RSC58 SGTC_3186 9110464 49.47 µM -1.1581769454634 0.115189582497998 no 3019 0.123395917278757 4247 17018021 SGTC_1902 st060212 70.5 µM -1.15997556605428 0.114826655838308 no 3020 0.123029377174085 4255 688944 SGTC_3038 9091290 49.47 µM -1.16054445952553 0.114712033715825 no 3021 0.122913601668605 4284 25236843 SGTC_334 1502-1024 68.5 µM -1.16300162053133 0.114217893846097 no 3022 0.122414422465218 4254 3296216 SGTC_1342 1486-1464 234 µM -1.16493222039432 0.113830711278101 no 3023 0.122023214981014 4279 3253938 SGTC_1557 sumaresinolic acid 42.3 µM -1.16570657663295 0.113675676947711 no 3024 0.121866550124815 4235 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2 0422-0095 29 µM -1.17092302612536 0.112635210023353 no 3025 0.12081485934073 4157 6790840 SGTC_2492 derrusnin 100 µM -1.17284408084936 0.112253757509379 no 3026 0.120429168683379 4271 1715307 Part of coumarin class of compounds. SGTC_1960 st011366 51.8 µM -1.17427401571578 0.111970423745428 no 3027 0.120142643837843 4270 3972846 SGTC_2112 5488546 200 µM -1.17516258102729 0.11179461719851 no 3028 0.119964838722738 4222 600757 SGTC_3338 9144300 39.5675 µM -1.17583655079397 0.111661401052405 no 3029 0.11983009870696 4255 4901274 SGTC_3344 9148862 3.898 µM -1.17671844763493 0.111487257839761 no 3030 0.119653951122722 4297 4905352 SGTC_1546 5-methoxyflavanone 78.7 µM -1.17859398807455 0.111117551803443 no 3031 0.11927994335328 4274 147795 SGTC_1053 3366-3204 134 µM -1.17928374455946 0.110981808237376 no 3032 0.119142604443625 4290 3632071 YPR165W RHO1 SGTC_2723 salbutamol 83.58 µM -1.18202808193206 0.110442901155023 no 3033 0.118597279235877 4277 9884233 β2-adrenoceptor agonist SGTC_2084 5306078 60.6385 µM -1.18241237333007 0.110367587645042 no 3034 0.118521057989344 4193 679340 SGTC_2062 5245942 200 µM -1.18351523968957 0.110151652175665 no 3035 0.118302505184683 4311 1376160 SGTC_808 0711-0032 135 µM -1.18383357369251 0.110089380440574 no 3036 0.118239474600409 4248 4252555 SGTC_971 1315-0384 26.7 µM -1.18925720013127 0.109032302083626 no 3037 0.117169235945599 4305 6769120 SGTC_3350 9150499 3.57 µM -1.18955481493426 0.10897450808754 no 3038 0.117110707189782 4282 4910996 YPR165W RHO1 SGTC_2796 7949634 45.45 µM -1.19096722485071 0.108700531587586 no 3039 0.116833225891117 4257 2971588 SGTC_835 0312-0010 67.2 µM -1.19121650679552 0.108652227841176 no 3040 0.116784300519162 4275 1626196 SGTC_438 sphingosine 6.67 µM -1.19151907053795 0.108593620341589 no 3041 0.116724937299409 4209 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1015 4130-4525 82 µM -1.19334552246295 0.108240314067198 no 3042 0.116367040505516 4277 1363237 SGTC_52 0329-0193 875 nM -1.19392462411106 0.108128466397313 no 3043 0.116253727137499 4350 3739292 SGTC_1349 flufenamic acid 69 µM -1.19400980965284 0.108112020687221 no 3044 0.116237065409857 4217 3371 A non-steroidal anti-inflammatory. SGTC_1236 0330-0013 258 µM -1.19947356132603 0.107060961125155 no 3045 0.115171929562836 4294 4617066 SGTC_2600 tangeritin 87.95 µM -1.20359201098593 0.106273582344322 no 3046 0.114373654412739 4210 68077 A bioactive flavone. SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.20404594734835 0.106187053857874 no 3047 0.114285909979569 4299 115019 SGTC_2247 cerulenin 830 nM -1.2047702394936 0.106049096067602 no 3048 0.114146005923282 4350 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2930 9013230 14.89 µM -1.20588119045166 0.105837742109481 no 3049 0.113931652085536 4300 2995857 SGTC_1914 st062367 72.6 µM -1.20625800891643 0.105766123103963 no 3050 0.113859011552267 4292 978205 SGTC_1974 st069448 26.9 µM -1.20702208785837 0.105621008015277 no 3051 0.113711818870961 4288 6323587 YNR016C ACC1 SGTC_2443 5493264 126.67 µM -1.20945842511014 0.105159256469735 no 3052 0.113243387133795 4332 5340055 SGTC_496 calpeptin 138 µM -1.21423445845708 0.104258311837694 no 3053 0.112329102763638 4293 73364 A calpain inhibitor. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.21805050884284 0.103542488123217 no 3054 0.111602389693211 4387 688664 SGTC_3332 9141069 11.198 µM -1.2180733150316 0.103538220833276 no 3055 0.111598056711196 4253 17332883 SGTC_1928 4'-methoxychalcone 40.3 µM -1.21885199372462 0.103392598009345 no 3056 0.111450186585571 4321 641818 SGTC_564 3555-0129 330 µM -1.22007622255759 0.103163952353907 no 3057 0.11121799065529 4193 563260 SGTC_1 0258-0098 57.368 µM -1.22628212530281 0.102010541339979 no 3058 0.110046262737618 4246 6790032 YDR047W HEM12 SGTC_1731 st035964 63 µM -1.23080928884907 0.101175075180082 no 3059 0.109197100298296 4222 6739575 SGTC_64 000l-0018 272.079 µM -1.23272979419001 0.100822165550198 no 3060 0.108838296013053 4240 6811119 SGTC_1436 4092-1007 8.32 µM -1.23276787467676 0.100815177015291 no 3061 0.108831190090387 4295 2881121 SGTC_2656 pseudo-anisatin 100 µM -1.23284073200206 0.100801807215768 no 3062 0.108817595644448 4357 6708809 A neurotoxin. SGTC_1842 st055362 61.2 µM -1.23425580693022 0.100542388014602 no 3063 0.10855379897756 4267 676032 SGTC_2715 st079500 56.4 µM -1.23739843801407 0.0999680065143164 no 3064 0.107969599206374 4284 28246688 SGTC_1531 st059297 52.4 µM -1.23787988732444 0.0998802236927578 no 3065 0.10788030049346 4339 7566702 SGTC_2830 7992007 71.43 µM -1.23830506273165 0.0998027481373343 no 3066 0.107801483644832 4192 1952075 SGTC_1171 0368-0077 21.4 µM -1.23851011305324 0.0997653995179891 no 3067 0.107763487290707 4270 3239779 SGTC_2617 dihydrotanshinone i 20.83 µM -1.23895640301202 0.0996841459221124 no 3068 0.107680821959591 4278 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1003 4049-0218 100 µM -1.24661166202779 0.098297914356204 no 3069 0.106269961765195 4338 295161 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.247554434226 0.0981281763358291 no 3070 0.106097137010062 4301 2724 A muscle relaxant with antifungal properties. SGTC_270 tamoxifen 5.46 µM -1.25021231826269 0.0976508034035706 no 3071 0.105610999076229 4368 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2000 st075254 36.4 µM -1.25078740919735 0.0975477378586872 no 3072 0.1055060248668 4225 17234175 SGTC_1758 st042942 75.2445 µM -1.25141775811702 0.0974348608617986 no 3073 0.105391050851887 4294 669317 SGTC_1889 st059080 5.18 µM -1.2528480570949 0.0971790916758164 no 3074 0.105130504212561 4298 176925 Isolated from Daphnopsis sellowiana. SGTC_3341 9147222 25.867 µM -1.2543657884837 0.0969082268040617 no 3075 0.104854540783155 4330 1939759 SGTC_2648 atorvastatin 78.68 µM -1.25509874990666 0.0967776160805954 no 3076 0.104721457114575 4328 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_3334 9142812 21.919 µM -1.25667643916455 0.0964969170045717 no 3077 0.104435411507861 4339 45283678 SGTC_2873 9040596 71.43 µM -1.25897128033944 0.0960896923117652 no 3078 0.104020352756935 4292 6463863 SGTC_2575 plumbagin 510 nM -1.25955328882062 0.0959866147558126 no 3079 0.103915277613658 4244 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1276 0871-0068 94.2 µM -1.26171439745818 0.0956045796221344 no 3080 0.103525787156273 4352 3414906 SGTC_2646 retinol 96.75 µM -1.26675650084911 0.0947176025538927 no 3081 0.10262118514667 4354 445354 A vitamin A analog and teratogen. SGTC_337 1315-0038 354 µM -1.26895043819152 0.0943335572963358 no 3082 0.102229370667494 4318 1626437 SGTC_158 k038-0087 26.446 µM -1.27078134868884 0.0940139393929967 no 3083 0.101903222910723 4250 X158 SGTC_1909 st060837 51.5 µM -1.27133886018322 0.0939167747595418 no 3084 0.101804061622238 4303 678937 SGTC_3239 9133757 49.47 µM -1.2880573063465 0.0910373735017977 no 3085 0.0988630077683228 4398 17036923 SGTC_538 2922-0838 53.3 µM -1.28848969236363 0.0909637825845688 no 3086 0.0987877773299396 4363 777039 SGTC_1725 st036284 20.55 µM -1.28914974506582 0.0908515285351673 no 3087 0.0986730161780147 4400 707914 SGTC_147 4466-0538 29.23 µM -1.29478795820848 0.0898968331086244 no 3088 0.0976966935707917 4453 6742687 YHR072W ERG7 SGTC_781 4335-2806 94.4 µM -1.29861736705528 0.089252679913809 no 3089 0.0970376374392678 4418 845254 SGTC_2378 9074213 121.43 µM -1.30098868466839 0.0888555208504419 no 3090 0.0966311639499789 4329 657714 SGTC_3229 9132204 49.47 µM -1.30131335676999 0.0888012458635333 no 3091 0.0965756085769633 4446 17682924 SGTC_1959 st077091 55.8 µM -1.30191132017032 0.0887013497544117 no 3092 0.0964733511235869 4373 821356 YKL052C ASK1 SGTC_171 k064-0041 9.68 µM -1.30510126135967 0.0881698501181436 no 3093 0.0959291846607793 4358 53325 SGTC_202 3594-0513 34.79 µM -1.30779619048034 0.0877226811391176 no 3094 0.0954712233406682 4439 708429 SGTC_2067 5224629 34.075 µM -1.31058091928232 0.0872623913757771 no 3095 0.0949996945647034 4366 2835000 SGTC_2005 4024620 188 µM -1.31064453245044 0.0872518978177562 no 3096 0.0949889432386241 4337 236743 SGTC_1526 st051518 75 µM -1.31499961108706 0.0865357270556582 no 3097 0.094255016591183 4364 673993 SGTC_128 0906-2981 13.371 µM -1.31790900732482 0.0860597457831118 no 3098 0.0937670550413483 4353 6740226 SGTC_1706 st031321 9.9705 µM -1.31837109628039 0.0859843279941641 no 3099 0.0936897257903844 4395 6103185 SGTC_3092 9117248 49.47 µM -1.3196281061928 0.0857794209822387 no 3100 0.0934796070847803 4503 17141857 SGTC_1293 1000-1278 195 µM -1.32021288878775 0.0856842193919992 no 3101 0.0933819749622923 4401 678847 SGTC_1953 st076800 12.1 µM -1.32173272497779 0.0854371626790225 no 3102 0.0931285836966709 4366 297591 SGTC_2810 7959871 45.46 µM -1.32326399687785 0.0851887870015354 no 3103 0.0928738000962903 4346 2974535 SGTC_13 0199-0087 65 µM -1.3257305546205 0.0847898441538283 no 3104 0.0924644814363125 4474 4589825 SGTC_805 3852-0218 479 µM -1.32955528205342 0.0841740026657668 no 3105 0.0918324200266027 4359 6615355 SGTC_2634 4'-methoxyflavone 100 µM -1.33010688758989 0.0840854632068642 no 3106 0.0917415282707448 4393 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3243 9134147 49.47 µM -1.33263473414619 0.0836806070306642 no 3107 0.0913258504003744 4478 24282180 SGTC_811 0416-0114 265 µM -1.33529531062526 0.0832560767024836 no 3108 0.0908898564116299 4421 6612453 SGTC_344 k064-0035 6.43 µM -1.33721078608338 0.0829514411086003 no 3109 0.0905769210571274 4343 5088750 SGTC_3121 9125696 49.47 µM -1.33938707322742 0.0826063446149754 no 3110 0.0902223477307143 4504 1235365 SGTC_594 1487-1584 10.8 µM -1.34087338542751 0.0823712800414512 no 3111 0.0899807823119004 4345 5013332 SGTC_1418 3966-3099 2.4 µM -1.34131791067315 0.0823010750257858 no 3112 0.0899086285406316 4390 740335 SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.3444745275427 0.0818038379598366 no 3113 0.0893974940253542 4393 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_51 1013-0126 23.419 µM -1.34935328797858 0.0810397842688581 no 3114 0.0886117585469263 4408 1627850 SGTC_358 0075-0058 9.45 µM -1.35381709609167 0.0803454451341483 no 3115 0.0878973689944452 4367 1069125 SGTC_1642 st009582 77.7 µM -1.3541546579846 0.0802931212424671 no 3116 0.0878435206600264 4383 6739311 SGTC_3074 9116018 49.47 µM -1.36010968168809 0.0793742899954273 no 3117 0.0868976088792995 4454 17027303 SGTC_2105 5350118 200 µM -1.36129506032963 0.079192345363458 no 3118 0.0867102317019433 4377 2133313 SGTC_765 1319-0117 244 µM -1.36131228541832 0.0791897038016796 no 3119 0.0867075110961111 4376 3487746 YGL099W LSG1 SGTC_247 mechlorethamine 29.705 µM -1.36671713761107 0.0783641305448943 no 3120 0.0858569920284695 4361 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1275 0867-0008 21.1 µM -1.37009764676292 0.0778510964296555 no 3121 0.0853282111643353 4393 3422836 SGTC_1444 4112-3581 28 µM -1.37222204492234 0.0775299994444999 no 3122 0.0849971623655015 4496 2877249 SGTC_1513 0337-0559 19 µM -1.37482132798904 0.0771384940862496 no 3123 0.0845934221067963 4402 775073 SGTC_1299 1079-1439 3.74 µM -1.37576343747438 0.0769969645949881 no 3124 0.0844474422821132 4402 323161 SGTC_759 3486-0358 89.3 µM -1.38024775801253 0.0763260066074039 no 3125 0.0837551870135778 4416 875103 SGTC_1493 4348-0038 111 µM -1.38114231543526 0.0761926940277923 no 3126 0.0836176034866795 4392 800424 SGTC_1727 st034309 9.9045 µM -1.38166537578798 0.0761148264310441 no 3127 0.0835372351690337 4455 870305 SGTC_2375 9072683 200 µM -1.38503987296553 0.0756139229664625 no 3128 0.0830201377612544 4466 16798029 SGTC_1682 st012968 530 nM -1.38522955356834 0.0755858418961974 no 3129 0.0829911433237614 4410 24207270 SGTC_2809 7964133 12.99 µM -1.38647291296498 0.0754019667451678 no 3130 0.0828012728938074 4408 1253665 SGTC_1887 st057648 70.8 µM -1.38708778991118 0.0753111612793352 no 3131 0.0827074973804718 4423 688672 SGTC_2159 5658611 73.75 µM -1.38814912914478 0.0751546181061621 no 3132 0.0825458195210837 4407 793844 SGTC_3279 9140807 49.47 µM -1.38863473599185 0.0750830758771755 no 3133 0.082471924552865 4474 45595718 SGTC_2331 7980721 200 µM -1.38940402203574 0.0749698468156538 no 3134 0.0823549639744897 4389 2981221 SGTC_724 3910-0327 137 µM -1.39600414151724 0.0740037397084004 no 3135 0.0813566240004231 4469 2885483 SGTC_2961 9083290 32.55 µM -1.39712035353351 0.0738412962978451 no 3136 0.0811886910887839 4371 17741490 SGTC_2040 5100729 123 µM -1.40316812876818 0.0729658922255481 no 3137 0.0802833545541924 4458 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_2849 9019321 12.99 µM -1.40522708233307 0.0726696820966827 no 3138 0.079976881653766 4448 16489627 SGTC_1840 st055363 71 µM -1.40524631523832 0.0726669195138993 no 3139 0.0799740230337269 4464 676033 SGTC_2811 7967822 32.47 µM -1.40880727552127 0.0721568137302711 no 3140 0.0794460816230888 4470 2232244 SGTC_1696 st025591 34.7925 µM -1.41261883752061 0.071613855401953 no 3141 0.0788839136105519 4437 2787147 SGTC_969 1313-0238 134 µM -1.41345120754904 0.0714957020810162 no 3142 0.0787615490737892 4477 5212874 SGTC_1744 st037937 38.9 µM -1.41489318244467 0.0712913706475255 no 3143 0.0785499085986322 4478 1016152 SGTC_592 k241-0073 46.5 µM -1.4192716110701 0.0706736832049488 no 3144 0.0779099226696529 4475 4230158 SGTC_2760 etidronate 98.04 µM -1.42104671606938 0.0704244349210571 no 3145 0.0776515894165671 4393 3305 A chelator and antioxidant. SGTC_364 0083-0097 67.7 µM -1.4238790873064 0.0700281326596338 no 3146 0.077240738264581 4470 5207356 SGTC_1529 apigenin 74 µM -1.42428177668124 0.0699719283906956 no 3147 0.0771824602788942 4445 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_614 0462-0418 107 µM -1.42519516786071 0.0698445729679408 no 3148 0.0770503963798265 4226 5188303 SGTC_809 3998-0021 90 µM -1.42522649666812 0.0698402079144989 no 3149 0.0770458697099269 4391 715485 SGTC_3130 9127414 49.47 µM -1.42595664999996 0.0697385348574603 no 3150 0.0769404277795454 4471 1494646 SGTC_296 1222-0039 74.9 µM -1.42737978880108 0.0695406918268519 no 3151 0.0767352266568374 4460 5984176 SGTC_3288 9119690 36.221 µM -1.43446848145653 0.0685616621399694 no 3152 0.0757193086432489 4435 17595618 YKL019W RAM2 SGTC_1362 1611-0397 101 µM -1.43873430877344 0.0679776471683356 no 3153 0.0751129073854863 4440 27816 SGTC_1905 st060207 84.5 µM -1.44102992855899 0.067664958038164 no 3154 0.074788113887449 4452 1948547 SGTC_146 3448-8650 53.125 µM -1.4476878264843 0.0667643612884803 no 3155 0.0738521880159014 4449 2891488 YIL048W NEO1 SGTC_1172 0370-0043 85 µM -1.44778705780754 0.0667510090168614 no 3156 0.0738383067057844 4485 376585 SGTC_597 k018-0003 82.8 µM -1.45303801718525 0.0660473989272701 no 3157 0.0731065994224569 4521 6786234 SGTC_2721 ifenprodil 61.44 µM -1.45659135799579 0.0655745329910846 no 3158 0.0726146073124039 4465 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_86 0417-1630 471.922 µM -1.45773025464026 0.0654235295059681 no 3159 0.0724574546135631 4444 3634867 SGTC_942 3253-1115 227 µM -1.45838046399452 0.0653374408793179 no 3160 0.0723678512225208 4505 46497897 SGTC_3022 9087993 49.47 µM -1.46033974147695 0.0650785611088167 no 3161 0.0720983624455433 4553 17173644 SGTC_1129 3453-1384 223 µM -1.46075552933642 0.0650237254966104 no 3162 0.0720412719897165 4473 1084452 SGTC_3198 9112019 49.47 µM -1.4623001626894 0.0648203276771078 no 3163 0.0718294869902561 4517 45595555 SGTC_3023 9089636 49.47 µM -1.46591126511308 0.0643467441341226 no 3164 0.0713362312893654 4555 17249241 SGTC_431 k089-0097 107 µM -1.47108647654325 0.0636727264802133 no 3165 0.0706338659016503 4205 5499420 SGTC_2055 5235184 200 µM -1.47253518926254 0.0634850341123997 no 3166 0.0704382058611232 4495 2836034 SGTC_9 0092-0002 10.449 µM -1.47329273201815 0.0633870599637006 no 3167 0.0703360598056092 4477 759368 SGTC_2044 5102272 200 µM -1.4735672538619 0.0633515847067761 no 3168 0.0702990717761301 4474 592666 SGTC_583 1488-1091 88.9 µM -1.47581401147547 0.0630618266452181 no 3169 0.0699969141330703 4580 4303273 SGTC_1000 4048-0884 8.67 µM -1.47655254291652 0.0629668060532848 no 3170 0.0698978104471176 4480 13040088 SGTC_3031 9088762 49.47 µM -1.47832474882172 0.0627392462559093 no 3171 0.0696604382243804 4455 205253 SGTC_1093 fluphenazine 7.97 µM -1.47942298095985 0.0625985499083216 no 3172 0.0695136509257112 4519 6602611 An atypical antipsychotic. SGTC_769 0302-0231 76 µM -1.47960745111845 0.0625749412733025 no 3173 0.0694890184298894 4390 571869 YER009W NTF2 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.48015506746108 0.0625048977901141 no 3174 0.0694159342337752 4506 6708784 An antioxidant flavonoid SGTC_587 k089-0003 57 µM -1.48307964807731 0.0621318604470209 no 3175 0.0690266252754825 4403 9659696 SGTC_2732 terfenadine 20 µM -1.48627789936153 0.0617259064535264 no 3176 0.0686028149899904 4557 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_624 k048-0052 28 µM -1.48642973901925 0.0617066850591537 no 3177 0.068582744256461 4484 6835531 SGTC_2340 7987427 183.45 µM -1.48961749803218 0.061304224361193 no 3178 0.0681624192313181 4482 2239331 SGTC_3156 9099931 49.47 µM -1.49191089898252 0.0610159487217887 no 3179 0.0678612525370857 4537 18111053 SGTC_1259 0671-0132 43 µM -1.49395637046798 0.0607597322889728 no 3180 0.0675935116002727 4426 X1259 SGTC_170 4197-0004 226 µM -1.49832753965841 0.0602150190142503 no 3181 0.0670240861448699 4501 218692 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -1.49895765390465 0.0601368135592018 no 3182 0.0669423089987613 4558 279621 SGTC_175 3793-3120 23.7 µM -1.50922496238768 0.058873679394261 no 3183 0.0656206515478664 4493 5322297 SGTC_1900 st060200 72.8 µM -1.50948311113097 0.0588421910696279 no 3184 0.0655876840352836 4485 688945 SGTC_3356 9151811 4.48 µM -1.51744834835968 0.0578770914380085 no 3185 0.0645767624780629 4524 1859254 YPR165W RHO1 SGTC_837 0091-0265 12.5 µM -1.51910956040135 0.0576773893369424 no 3186 0.064367460331414 4497 759367 SGTC_603 3794-0023 45.9 µM -1.52074603846721 0.0574811908365001 no 3187 0.0641617903101366 4541 3802260 SGTC_351 caspofungin 25 nM -1.52151701706338 0.0573889397922321 no 3188 0.0640650721146543 4491 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1154 4088-0362 150 µM -1.52384537919838 0.0571110478009172 no 3189 0.06377367030554 4515 6618304 SGTC_104 0074-0074 590.992 µM -1.52395624987057 0.0570978417588684 no 3190 0.0637598202529768 4362 3943124 SGTC_1963 st076565 50.3 µM -1.52709757526201 0.0567246697755841 no 3191 0.0633683749003625 4522 4914280 SGTC_282 k297-0036 65.7 µM -1.52784839079332 0.0566357621566587 no 3192 0.0632750922036527 4513 5061378 SGTC_2528 xanthyletin 44.79 µM -1.52791695058164 0.0566276491410448 no 3193 0.0632665795397462 4536 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2267 7931562 200 µM -1.53402086746899 0.0559090051698834 no 3194 0.0625122595937298 4460 934880 SGTC_204 PMA1.184 62.41 µM -1.53728456304507 0.0555277169729633 no 3195 0.0621118200179073 4483 2252213 YGL008C PMA1 SGTC_1879 gemcitabine 100 µM -1.54043899733294 0.0551611471491804 no 3196 0.0617266908815706 4472 60750 A nucleoside analog which inhibits DNA replication. SGTC_3037 9091026 49.47 µM -1.54276591079557 0.0548919688998739 no 3197 0.0614437916708378 4390 25236398 YIL048W NEO1 SGTC_350 k064-0020 19.8 µM -1.55657233254252 0.0533161292063635 no 3198 0.0597860284568761 4526 2790705 SGTC_177 1327-0068 8.361 µM -1.55813412665884 0.0531401494895941 no 3199 0.0596007281879178 4515 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2931 9014674 55.67 µM -1.56391393154629 0.052492895728211 no 3200 0.0589188911638922 4481 2996810 SGTC_2678 equilin 100 µM -1.56759303843294 0.0520841596204352 no 3201 0.0584880689081119 4530 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_923 1900-2434 73.3 µM -1.57582402609173 0.0511788804500918 no 3202 0.0575331818635063 4512 5910570 SGTC_675 1309-0189 238 µM -1.57605436438724 0.0511537281001841 no 3203 0.0575066374748623 4538 4246530 SGTC_1523 st012844 44.7 µM -1.5772394792147 0.0510244720685918 no 3204 0.0573702160583798 4572 4274103 SGTC_188 3229-0966 278.469 µM -1.58379978327988 0.050313660074536 no 3205 0.0566196443207083 4588 5722370 SGTC_2100 5377183 190 µM -1.59361194097913 0.0492652617220923 no 3206 0.0555114891541514 4558 2844202 SGTC_2563 tomatine 8.54 µM -1.59784069142029 0.0488188455217085 no 3207 0.0550392180446238 4476 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_3307 9126885 69.2785 µM -1.59987288258652 0.0486054664350789 no 3208 0.0548133931031044 4516 24824909 SGTC_1168 k815-0004 80.5 µM -1.60405210692773 0.048168993547863 no 3209 0.0543512837152312 4545 642433 SGTC_1839 st053978 48 µM -1.60602785761466 0.0479637432624996 no 3210 0.0541338946336787 4574 3788398 SGTC_212 3807-4682 38.772 µM -1.60797557461186 0.0477620910549257 no 3211 0.0539202641834582 4620 3125501 YBL034C STU1 SGTC_1209 2323-2347 50.3 µM -1.60812646782522 0.0477464970641785 no 3212 0.0539037417375385 4563 5412760 SGTC_1116 jasmonic acid  1.58368 µM -1.60953729740342 0.0476008927028422 no 3213 0.053749453156922 4587 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1319 1306-0155 43.7 µM -1.61656144879923 0.0468812521559768 no 3214 0.0529864895680668 4579 3122360 SGTC_1539 benzyladenosine 56 µM -1.61978533070845 0.0465538925453366 no 3215 0.0526391992497554 4564 92208 A nucleotide analog. SGTC_1446 4239-0190 62 µM -1.62232190842153 0.0462976148773142 no 3216 0.052367220053531 4567 1340085 SGTC_534 k292-0788 63.4 µM -1.62603409928169 0.0459246049072841 no 3217 0.0519712008028779 4606 4146317 SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.62795070870379 0.0457329666679391 no 3218 0.0517676689423288 4587 5282309 SGTC_178 4092-0806 87.505 µM -1.6297506482588 0.0455535798090369 no 3219 0.0515771040485476 4449 2169044 SGTC_325 2810-4341 181 µM -1.63078375624568 0.0454508732933819 no 3220 0.0514679780716776 4556 774970 SGTC_15 0266-0086 27.098 µM -1.6322252415756 0.045307879195087 no 3221 0.0513160226064849 4625 1712902 YIL048W NEO1 SGTC_1766 st045414 44.774 µM -1.63444703805978 0.0450881878954863 no 3222 0.0510825091484113 4558 253960 SGTC_2326 6164455 177.58 µM -1.63679149957438 0.0448572978795008 no 3223 0.0508370212438553 4492 2888790 SGTC_2361 9034121 116 µM -1.64426733681 0.0441274047524115 no 3224 0.0500604965713141 4577 6496917 SGTC_2585 alliin 100 µM -1.64657219149389 0.0439043145090316 no 3225 0.04982300511387 4581 87310 A garlic compound which reacts with lipids. SGTC_1588 farnesol 29.9 µM -1.65492775942234 0.0431031828927948 no 3226 0.0489695762799028 4583 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1184 1269-1718 139 µM -1.66251005413598 0.0423864517725257 no 3227 0.0482052745682796 4619 5403821 SGTC_2718 lomofungin 53.02 µM -1.66371639075922 0.0422733144581842 no 3228 0.0480845595869691 4546 5351222 A RNA synthesis inhibitor. SGTC_2591 skatole 100 µM -1.67217725375823 0.0414866551621113 no 3229 0.0472446872185163 4563 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2800 7887935 81.82 µM -1.67345435086709 0.0413689524462312 no 3230 0.0471189429622097 4555 2961002 SGTC_2293 7624732 200 µM -1.67437741895049 0.0412840471768599 no 3231 0.0470282239155942 4477 894453 SGTC_2495 cafestol 54.53 µM -1.68153666499816 0.0406303145688567 no 3232 0.0463293604600885 4580 16667697 An anti-infammatory. SGTC_114 0364-0001 490.298 µM -1.69022407366735 0.0398483510529968 no 3233 0.0454925472104872 4582 4003655 SGTC_258 haloperidol 50.781 µM -1.69069703776671 0.0398061326100956 no 3234 0.0454473401841529 4568 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2654 protoveratrine a 100 µM -1.69408287515781 0.0395049616700884 no 3235 0.0451247679759669 4592 5702278 A heart drug and vasodilator. SGTC_1684 st024538 14.6195 µM -1.70088377139592 0.0389056210827022 no 3236 0.0444824072923221 4575 6732859 SGTC_1723 st034307 2.5525 µM -1.70090687647344 0.0389035976007787 no 3237 0.044480237586886 4579 867466 SGTC_999 SEC7.066 22.7 µM -1.70985799841464 0.03812610628036 no 3238 0.0436460674616915 4571 740511 YDR170C SEC7 SGTC_668 1682-0499 62.6 µM -1.71074595608898 0.0380496744436429 no 3239 0.0435640100470201 4578 682214 SGTC_1175 0741-0056 27.6 µM -1.71300499780827 0.0378557885601773 no 3240 0.0433558100717642 4648 765927 SGTC_2943 9068529 45.32 µM -1.71813466348797 0.0374185198637761 no 3241 0.0428860277502232 4555 3270634 SGTC_2993 9054257 71.4286 µM -1.73238869084302 0.0362250826904719 no 3242 0.0416021900955516 4529 6470217 YGL055W OLE1 SGTC_3247 9135149 49.47 µM -1.73412564051274 0.0360818083108 no 3243 0.04144789649137 4629 8934436 YOR116C RPO31 SGTC_1697 st025554 27.742 µM -1.73447546376622 0.0360530089364029 no 3244 0.0414168777894192 4623 1269519 SGTC_581 0958-0271 211 µM -1.73818444770893 0.035748821387879 no 3245 0.0410891592880739 4615 4591145 SGTC_1041 0206-0046 107 µM -1.74504303964603 0.035191864215872 no 3246 0.0404886886896491 4613 50494 SGTC_2254 7938975 95.19 µM -1.74729917075072 0.0350102168939581 no 3247 0.0402927284339176 4632 2969277 SGTC_197 4544-0043 41.561 µM -1.7486069537298 0.0349052764544873 no 3248 0.0401794917405636 4628 896523 SGTC_91 0417-1751 58.384 µM -1.74993775391501 0.0347987542484419 no 3249 0.0400645275816463 4670 6795624 SGTC_2529 gangaleoidin 93.61 µM -1.75507830743284 0.0343897891142501 no 3250 0.039622957126092 4588 4565183 SGTC_885 0865-0106 16.8 µM -1.75787344620812 0.0341690800726643 no 3251 0.0393845224380129 4577 2793380 SGTC_1221 2958-7315 257 µM -1.76415172222073 0.0336775800707709 no 3252 0.0388532191838879 4644 4562705 SGTC_643 k048-0106 28.4 µM -1.76563683807985 0.0335621714409156 no 3253 0.038728397795958 4639 6763920 SGTC_1314 1222-0010 41.1 µM -1.77075731906496 0.0331667515362051 no 3254 0.0383005331098487 4624 3526027 SGTC_2133 5320837 200 µM -1.77107757739707 0.0331421482276419 no 3255 0.0382739010664552 4619 2841355 SGTC_2903 5923464 63.88 µM -1.77249610879873 0.0330333526603744 no 3256 0.0381561203301885 4626 2876576 SGTC_2900 5328528 85.29 µM -1.78390538615754 0.0321689682706368 no 3257 0.0372195202797352 4602 795359 SGTC_2020 4017018 200 µM -1.78615123005293 0.0320010383596937 no 3258 0.0370373875828099 4629 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_954 1189-0853 2.85 µM -1.78747343354756 0.031902511396895 no 3259 0.0369305010949829 4565 2828194 SGTC_1013 4112-3890 241 µM -1.79637173368327 0.0312459326151874 no 3260 0.0362177081134356 4614 705171 SGTC_2610 ononetin 44.17 µM -1.79662493810428 0.0312274141962932 no 3261 0.0361975913093895 4592 259632 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.79754796262965 0.0311599845002606 no 3262 0.0361243355042064 4583 6857784 SGTC_1256 0570-0116 285 µM -1.80513703082469 0.0306101343603422 no 3263 0.0355266208017281 4616 410638 SGTC_1131 3454-3128 32.3 µM -1.80677809084015 0.0304922975892442 no 3264 0.0353984430446489 4598 710982 SGTC_2850 9015429 58.44 µM -1.81279102097241 0.0300637439578091 no 3265 0.0349320296860238 4611 6457570 SGTC_2092 5303694 80.6725 µM -1.8309270428054 0.0288013019391099 no 3266 0.0335557166637646 4649 1963699 SGTC_2990 9074105 71.4286 µM -1.84269999128754 0.0280056231159102 no 3267 0.0326864126520231 4559 6502001 SGTC_2264 7948757 110.76 µM -1.8440460545527 0.0279158264658387 no 3268 0.0325882143319055 4596 2971411 SGTC_2838 9002687 71.43 µM -1.84940240991151 0.0275608736184496 no 3269 0.0321998638616714 4627 6457060 SGTC_1335 1486-0900 202 µM -1.86130176309611 0.0267857809861141 no 3270 0.0313507871676424 4652 X1335 SGTC_2106 5357045 167.29 µM -1.86177243244027 0.0267555008944134 no 3271 0.0313175869269899 4657 668842 SGTC_3274 9138298 49.47 µM -1.86639034547884 0.0264599248846094 no 3272 0.0309933864397504 4614 17015756 SGTC_2797 7859098 81.82 µM -1.87259436941452 0.0260671274674768 no 3273 0.0305622097266569 4613 972681 SGTC_521 r062-0005 13.8 µM -1.87301904283035 0.0260404192669726 no 3274 0.030532877715618 4588 2832033 SGTC_1571 st070080 73.4 µM -1.87603929176032 0.0258511318357689 no 3275 0.0303249423775173 4634 4315245 SGTC_723 4182-0001 115 µM -1.88071832307229 0.0255601582102793 no 3276 0.0300051229063625 4646 744821 YLR208W SEC13 SGTC_216 k038-0035 28.382 µM -1.88093349636415 0.0255468435113823 no 3277 0.0299904829850673 4614 4444231 YPR107C YTH1 SGTC_2560 caryophyllene 100 µM -1.88204778151068 0.0254779855860428 no 3278 0.0299147641879643 4677 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_405 ebelactone b 50 µM -1.88389405813458 0.0253642359586931 no 3279 0.0297896535636845 4635 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_70 0141-0289 43.283 µM -1.89377351097311 0.0247627651276989 no 3280 0.0291275395384212 4627 352408 SGTC_2674 ligustilide 100 µM -1.89636741999455 0.024606843326848 no 3281 0.0289557384319039 4691 5319022 A signalling regulator. SGTC_574 1315-0397 40 µM -1.90204081361839 0.024268681367609 no 3282 0.0285829095454757 4642 6794277 SGTC_1555 citronellol 128 µM -1.91114856856936 0.0237339798223366 no 3283 0.0279927455608077 4651 8842 A terpine precursor. SGTC_1676 st018489 23.4 µM -1.91148546847365 0.023714392481002 no 3284 0.0279711112401501 4610 3696235 SGTC_131 0141-0277 33.849 µM -1.91838206804729 0.0233164020383426 no 3285 0.0275312915545561 4611 1547771 SGTC_323 4013-0906 34.3 µM -1.91855606522876 0.0233064341208991 no 3286 0.0275202701550677 4679 2910086 SGTC_1193 1488-0126 41.5 µM -1.9188966609092 0.0232869325217315 no 3287 0.0274987066536228 4649 1384710 SGTC_3109 9122853 49.47 µM -1.91991370049558 0.0232287812713723 no 3288 0.0274344005353584 4686 1234709 SGTC_3036 9090181 49.47 µM -1.92232340715627 0.02309148929303 no 3289 0.0272825382382146 4711 25236586 SGTC_571 k831-0106 44.2 µM -1.92699092397966 0.022827502689785 no 3290 0.0269903805166222 4580 4783639 SGTC_355 1311-2252 105 µM -1.92762246076079 0.0227919801427635 no 3291 0.0269510515169132 4632 5338538 SGTC_2181 6316240 54.2555 µM -1.9552997221367 0.0212803195929652 no 3292 0.0252738519920659 4686 12779990 SGTC_1373 2887-0003 58.5 µM -1.96387841752464 0.020829342106507 no 3293 0.0247720966460959 4650 776948 SGTC_2992 9074591 71.4286 µM -1.96482573154621 0.0207800420418278 no 3294 0.0247172054665441 4626 17741321 SGTC_1057 3448-5381 134 µM -1.96684850335209 0.0206751037072604 no 3295 0.0246003394407602 4661 5497911 SGTC_245 methotrexate 289.6 µM -1.9690048342909 0.0205637311232665 no 3296 0.0244762679728934 4625 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1207 2099-0101 141 µM -1.97745339378034 0.0201322546873493 no 3297 0.0239952018474328 4680 5837381 SGTC_507 nimesulide 162 µM -1.9784886003696 0.0200799174862016 no 3298 0.0239368066732164 4682 4495 A COX2 inhibitor. SGTC_2511 berberine 10.47 µM -1.97945894987791 0.0200309641090047 no 3299 0.0238821785239439 4672 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2036 5160441 105 µM -1.98269363861492 0.0198685071856242 no 3300 0.023700830297664 4657 134534 YIL048W NEO1 SGTC_1381 2324-0066 62.1 µM -2.01108991125573 0.0184897476261452 no 3301 0.0221579803101991 4691 10885928 SGTC_2904 7225135 42.03 µM -2.01457677114588 0.018326199841192 no 3302 0.0219745066991472 4721 4446116 SGTC_2231 micatex 6.853 µM -2.01595223388827 0.0182620249014821 no 3303 0.0219024854146054 4698 20737 An antifungal of unknown mechanism. SGTC_379 3970-0972 5.9 µM -2.01955831494769 0.0180946844623058 no 3304 0.0217146113555415 4689 2898042 YBL034C STU1 SGTC_768 0384-0033 77.3 µM -2.02007898242077 0.0180706311746812 no 3305 0.0216875977835696 4663 3965305 YMR134W ERG29 SGTC_898 1000-0849 28.3 µM -2.03158765313531 0.0175458832762193 no 3306 0.0210977088408716 4688 6751807 SGTC_2510 benzyl isothiocyanate 8.31 µM -2.03892627336024 0.0172181094690653 no 3307 0.0207286931416717 4701 2346 DNA damaging agent; causes G2/M arrest. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -2.03906776491547 0.017211841614424 no 3308 0.0207216324212969 4672 5379071 SGTC_2611 pyromycin 23.93 µM -2.07718601355235 0.0155927517582148 no 3309 0.0188921971268236 4646 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_398 bronopol 33.3 µM -2.08196552024023 0.0153992694164983 no 3310 0.0186728096289636 4645 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_3191 9110352 49.47 µM -2.10619543799325 0.0144498102537995 no 3311 0.0175936896391361 4680 17122424 SGTC_1167 k781-0610 148 µM -2.1168239771149 0.0140494969436722 no 3312 0.0171373948103497 4720 4525169 SGTC_229 benomyl 22.8748 µM -2.14371888801988 0.0130789691168139 no 3313 0.016027708925726 4735 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2516 gossypol 71.55 µM -2.1464637785846 0.012983255900362 no 3314 0.01591799781233 4724 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_120 rhodamine 6G 52.259 µM -2.14647114893505 0.0129829997166489 no 3315 0.0159177040941563 4703 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1384 3089-0840 101 µM -2.15366973452823 0.0127348638044216 no 3316 0.0156330406237287 4715 1069836 SGTC_2553 4-methylesculetin 85.09 µM -2.16970901833208 0.0121967026383467 no 3317 0.0150144482166311 4695 5319502 SGTC_2319 6033012 152.6 µM -2.181679001764 0.0118080265185397 no 3318 0.0145666158601104 4682 847246 SGTC_586 0957-0265 8.15 µM -2.18231671630182 0.0117876243452533 no 3319 0.0145430830657641 4665 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2622 2-methoxyxanthone 59.94 µM -2.18862218154631 0.0115875368750581 no 3320 0.0143121561214811 4702 71034 A hepatoprotective. SGTC_557 1315-0110 16.2 µM -2.1963600433194 0.0113460315296435 no 3321 0.0140330916049756 4710 6833801 SGTC_8 0354-0001 70 µM -2.20714636987255 0.0110166849791045 no 3322 0.0136519175610984 4729 4993152 SGTC_1473 k844-0725 134 µM -2.22302684094672 0.0105469387006911 no 3323 0.0131069950623948 4758 54682906 SGTC_2014 4013930 200 µM -2.2232525804689 0.0105403890746979 no 3324 0.0130993865462421 4695 64556 SGTC_1386 3228-0095 33.8 µM -2.2386637836758 0.0101015447731693 no 3325 0.0125889003364608 4727 870181 SGTC_2377 9073351 62.6 µM -2.24299538149908 0.00998110612046435 no 3326 0.0124485561659309 4711 7337946 YHR072W ERG7 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -2.24967479452552 0.00979784389063394 no 3327 0.0122347983406527 4736 803109 SGTC_2294 7971431 200 µM -2.25507235613968 0.00965190562606575 no 3328 0.0120643937375666 4720 5741572 SGTC_2431 5490079 200 µM -2.25553038487213 0.00963960942187326 no 3329 0.0120500286428877 4745 5722345 SGTC_1901 st060216 58.6 µM -2.27078789782896 0.00923775593496685 no 3330 0.0115799104623991 4722 688792 SGTC_214 4373-3496 70 µM -2.31814309977078 0.00808238741022781 no 3331 0.010220772603739 4760 3779166 SGTC_215 1287-0124 461.5 µM -2.35763424234237 0.00721804226480533 no 3332 0.00919590206382087 4770 5560863 SGTC_369 0957-0393 4.5 µM -2.42797291735812 0.00587871109143032 no 3333 0.00759173851930621 4738 6997992 SGTC_2947 9072639 7.68 µM -2.4842173358021 0.00497144847500642 no 3334 0.00649182698130608 4712 16488146 SGTC_1046 2001-0062 216 µM -2.53509444646502 0.00426051185424747 no 3335 0.00562085062502064 4759 739778 SGTC_2769 toremifene 3.73 µM -2.55204386482449 0.00404470625066247 no 3336 0.00535465174178267 4757 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_471 1-acyl-paf 4 µM -2.59199454070411 0.00357427260497485 no 3337 0.00477106428972738 4759 16759367 SGTC_1040 k898-0338 155 µM -2.61263815273726 0.00335096729036683 no 3338 0.00449231856758741 4753 20969351 SGTC_573 3702-0553 84.7 µM -2.62047288470504 0.00326955591939972 no 3339 0.00439039563418406 4766 1222756 SGTC_1752 st044819 83.042 µM -2.68385914900602 0.00267360053233905 no 3340 0.00363888800413691 4749 441209 YML126C ERG13 SGTC_87 0100-0052 35.5 µM -2.70243321043416 0.00251859749043817 no 3341 0.00344170060984263 4772 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2166 5933061 31.504 µM -2.70503101227888 0.0024975785574735 no 3342 0.00341490064707512 4733 2877375 SGTC_757 1066-0008 322 µM -2.72319418211426 0.00235499641720183 no 3343 0.0032327021806737 4773 6842497 SGTC_1897 st060201 15 µM -2.73049009222721 0.00229982805605936 no 3344 0.00316201169916746 4783 611878 SGTC_2913 7966556 36.57 µM -2.73442332224884 0.00227057480579811 no 3345 0.00312448239537653 4725 2976516 SGTC_2406 ethylparaben 405.7 µM -2.74035054561694 0.00222712766797337 no 3346 0.00306868436859497 4746 8434 A possible steroid mimic. SGTC_383 2324-0395 7.37 µM -2.84638105081357 0.00156699736380096 no 3347 0.00221096230170812 4777 3146421 SGTC_2368 9071271 200 µM -2.90059979346511 0.00130348559146321 no 3348 0.00186224611383515 4781 27209959 SGTC_2337 9009472 200 µM -2.93298349264944 0.00116609767812121 no 3349 0.00167860870646103 4756 5742383 SGTC_2258 7960471 200 µM -2.99847140305571 0.000927931035915531 yes 3350 0.00135668809593693 4788 2974708 SGTC_2240 6690706 185.951 µM -3.14908633504334 0.000539748649189817 yes 3351 0.000818909005840125 4766 805876 SGTC_259 usnic acid 108.925 µM -3.22402976623408 0.000408680176138988 yes 3352 0.00063200130112129 4801 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1747 st037496 66.6 µM -3.25321890066774 0.00036615197466222 yes 3353 0.000570527793994604 4769 723305 SGTC_966 1300-0360 30.2 µM -3.28845562732704 0.000320295631049913 yes 3354 0.000503693314411319 4796 70588 SGTC_428 3448-4153 16.5 µM -3.64866707960572 7.58528015737931e-05 yes 3355 0.000131802221230156 4798 3834874 SGTC_2427 5545055 42.75 µM -3.76181532456035 4.69417545091321e-05 yes 3356 8.43422915854819e-05 4803 5372858