SGTCid condition conc unit IST2|YBR086C.score IST2|YBR086C.strain.pval IST2|YBR086C.strain.significant IST2|YBR086C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_922 1866-0035 480 µM 8.02751813824779 4.63313163603418e-15 yes 1 4.97321337688836e-16 9 3156169
SGTC_1687 st020778 55.3625 µM 6.14644558221826 1.53343032309035e-09 yes 2 3.96192450400984e-10 106 4259299
SGTC_2529 gangaleoidin 93.61 µM 5.22750198139733 2.34718841113224e-07 yes 3 8.59077789387407e-08 6 4565183
SGTC_930 2810-3379 265 µM 4.7356179623263 2.53059408605283e-06 yes 4 1.09194317436627e-06 5 1015764
SGTC_2162 5663267 200 µM 4.53113475634991 6.37691664727598e-06 yes 5 2.93338494371703e-06 8 6456493
SGTC_363 0455-0021 3.06 µM 4.41899235383707 1.0418508715233e-05 yes 6 4.95810776403724e-06 49 4597466
SGTC_3192 9110362 49.47 µM 4.10836149933869 3.82635957166276e-05 yes 7 1.99238025841252e-05 10 16649480
SGTC_1919 st067113 52.3 µM 3.68211236765576 0.000198255395844819 yes 8 0.000115654705470686 40 1268243
SGTC_562 3772-2733 112 µM 3.65851620606057 0.000216137188850945 yes 9 0.000126839851090288 92 2876874 YIL048W NEO1
SGTC_1826 st055655 41.6 µM 3.65454138195745 0.000219293704891028 yes 10 0.000128821053572682 50 676168
SGTC_2018 5133068 143 µM 3.61015923421887 0.000257585658495267 yes 11 0.000153004543854352 31 785362
SGTC_1087 pterostilbene 9.05 µM 3.48042205100266 0.000408234858250626 yes 12 0.000250312237607431 46 5281727 Similar to reservatol, lowers cholesterol.
SGTC_724 3910-0327 137 µM 3.44052488808713 0.000468939132794609 yes 13 0.000290293519035013 36 2885483
SGTC_568 1193-0097 7.48 µM 3.41620055543726 0.000509946409346997 yes 14 0.000317507301445927 183 3646150
SGTC_2534 helenine 20.12 µM 3.37704998754835 0.000582975130377129 yes 15 0.000366338668025441 23 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_3054 9094397 49.47 µM 3.36488534471252 0.000607563171741831 yes 16 0.000382877362511117 53 2598354
SGTC_2051 5263410 176 µM 3.3287963785569 0.00068625681968214 yes 17 0.000436110737057495 35 227584
SGTC_2321 7390090 138.78 µM 3.30296363485991 0.000748246961966699 yes 18 0.000478343967019583 56 649046
SGTC_3280 9140961 49.47 µM 3.25424763857478 0.000879392335351527 yes 19 0.000568465622004401 36 4901226
SGTC_626 0214-0009 33 µM 3.21420777625986 0.00100266101562127 no 20 0.000654024916309653 47 3437874
SGTC_2759 disulfiram 3.38 µM 3.20211869012371 0.0010428833461637 no 21 0.00068210388181269 70 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2882 9058044 58.44 µM 3.18259033512486 0.00111099417893624 no 22 0.000729819875019901 39 18076804
SGTC_531 3788-1495 174 µM 3.17484126035812 0.00113913326404698 no 23 0.000749592450767305 49 2896655
SGTC_2560 caryophyllene 100 µM 3.17421486655616 0.00114143616008081 no 24 0.000751212127614482 46 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2835 9006588 71.43 µM 3.14413988272719 0.00125715410020008 no 25 0.000832878967203539 85 2345538
SGTC_3028 9087778 49.47 µM 3.14168446382874 0.00126706022166996 no 26 0.000839894789237205 40 17217395
SGTC_3274 9138298 49.47 µM 3.12724285283012 0.001326782329113 no 27 0.000882270524267876 50 17015756
SGTC_1028 k015-0029 4.8 µM 3.12033387482634 0.00135625416577625 no 28 0.000903230800104415 60 4588309
SGTC_2969 9091408 28.7 µM 3.08838978309074 0.00150045063940656 no 29 0.00100622163328922 71 4286311
SGTC_28 pentachloropyridine N-oxide 1.606 µM 3.02210145985754 0.00184522886703388 no 30 0.00125513197174198 130 140250 A respiratory chain inhibitor.
SGTC_3339 9145883 14.936 µM 3.01815462695805 0.0018678688358932 no 31 0.00127159552060555 48 2030670
SGTC_360 0957-0399 1.01 µM 2.88027972583022 0.00283581006134467 no 32 0.00198661241105986 111 6752301 YPR165W RHO1
SGTC_1264 0783-0040 158 µM 2.85299003566186 0.00307412622587804 no 33 0.00216549897833267 80 2855798
SGTC_2168 5727979 200 µM 2.82336066684727 0.00335316467000326 no 34 0.00237615386618862 67 695210
SGTC_2806 7952793 58.44 µM 2.81671745704788 0.00341877051625009 no 35 0.00242585931818719 87 2972490
SGTC_21 0849-0113 22.993 µM 2.79968910845683 0.0035922343460809 no 36 0.00255759224873577 108 1560156
SGTC_2343 7990716 14.84 µM 2.79925298598396 0.00359677896565999 no 37 0.00256104947134921 68 6456862
SGTC_2951 9072950 58.06 µM 2.68920241951607 0.004922668388843 no 38 0.00358114869349041 97 16488155
SGTC_2337 9009472 200 µM 2.68705919033007 0.00495233424341591 no 39 0.00360420888875128 112 5742383
SGTC_2090 5301565 104.445 µM 2.64474256714361 0.00557160494556192 no 40 0.00408765437687431 131 2056344
SGTC_3278 9139605 49.47 µM 2.60945587793627 0.0061396172413427 no 41 0.00453431699729381 80 7958859
SGTC_1077 5-fluorocytosine 377 nM 2.58412016850012 0.00657851532784973 no 42 0.00488138862092607 90 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_543 3844-1095 191 µM 2.58070924815142 0.006639674497542 no 43 0.0049298791636146 153 4230703
SGTC_2062 5245942 200 µM 2.57024045650095 0.00683053437875679 no 44 0.00508139735894107 112 1376160
SGTC_2280 7785178 200 µM 2.54815978471183 0.00724905453020213 no 45 0.00541464287209089 78 2954328
SGTC_3030 9087619 49.47 µM 2.53427078866405 0.00752374844259488 no 46 0.00563408091356577 105 25236973
SGTC_2058 5236698 133 µM 2.53183160574772 0.00757292534252439 no 47 0.00567342347879704 124 766665
SGTC_2974 9094440 9.66 µM 2.52684249755833 0.00767439424383836 no 48 0.0057546552594166 149 25236134
SGTC_540 1187-0821 17.3 µM 2.50199782673609 0.00819770952780255 no 49 0.0061747341473456 123 847520
SGTC_1633 st005664 67.9 µM 2.49391181158128 0.00837466381538856 no 50 0.00631719652190311 154 2063822
SGTC_898 1000-0849 28.3 µM 2.48905812506371 0.00848248491986392 no 51 0.00640410118633261 70 6751807
SGTC_3316 9136639 10.545 µM 2.45330773858766 0.00931487119969938 no 52 0.00707745923270835 96 4903665
SGTC_2054 5233173 129 µM 2.45281691827957 0.00932677967575992 no 53 0.00708712298697417 189 6889
SGTC_2779 methotrexate 400 µM 2.43318228067588 0.00981421625783641 no 54 0.00748338207455915 148 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3279 9140807 49.47 µM 2.43072732092491 0.00987669968563687 no 55 0.00753427511935293 96 45595718
SGTC_759 3486-0358 89.3 µM 2.41903331800084 0.0101791260895251 no 56 0.00778090738134297 131 875103
SGTC_564 3555-0129 330 µM 2.41891668639114 0.0101821826188094 no 57 0.00778340256358983 69 563260
SGTC_3194 9111903 49.47 µM 2.40999281216283 0.0104184347005323 no 58 0.00797641740522716 129 17087251
SGTC_2172 5754775 163.918 µM 2.40255407697455 0.0106190062202012 no 59 0.00814051357840616 137 2263357
SGTC_2031 5180455 200 µM 2.40068804268195 0.0106698449356024 no 60 0.00818214024808379 98 29949
SGTC_1780 st038448 24.544 µM 2.40058923976055 0.0106725426465028 no 61 0.00818434950384466 136 728868 YDL195W SEC31
SGTC_2170 morpholine 200 µM 2.39356526578947 0.0108658534070733 no 62 0.00834275623523878 100 121171 Reacts with secondary amines.
SGTC_1104 tacrolimus 29.8 µM 2.3751756881856 0.0113864618190212 no 63 0.00877029952484344 146 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_424 splitomicin 100 mM 2.37021788860211 0.0115304736012159 no 64 0.00888880254803488 139 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3201 9113999 49.47 µM 2.36736379421431 0.0116140933118476 no 65 0.00895765651742947 155 16649224
SGTC_2795 7780010 54.55 µM 2.36107951904129 0.0118000689468693 no 66 0.00911091145386305 147 953673
SGTC_2005 4024620 188 µM 2.35844937645709 0.0118786687028837 no 67 0.00917573131123812 130 236743
SGTC_1819 st053448 58.6 µM 2.35413096465906 0.0120087062397366 no 68 0.00928303427754803 131 2857616
SGTC_3088 9117578 49.47 µM 2.33557767520772 0.0125815311866108 no 69 0.00975663162058911 90 678341
SGTC_2528 xanthyletin 44.79 µM 2.32859782621244 0.0128030743968759 no 70 0.00994019066799604 126 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2142 5622915 118.518 µM 2.32606078869825 0.0128844331027688 no 71 0.0100076539948855 112 5322196
SGTC_2804 7954240 19.48 µM 2.32374271975331 0.0129591603602425 no 72 0.010069643688328 161 828705
SGTC_66 0109-0187 42.4 µM 2.32326965255933 0.0129744565168366 no 73 0.0100823355179148 159 759417
SGTC_1293 1000-1278 195 µM 2.31606790393983 0.0132092527215342 no 74 0.010277280710025 156 678847
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 2.31421207232752 0.0132703494200542 no 75 0.0103280460426628 152 6708514
SGTC_2352 9027995 87.8 µM 2.30408707529346 0.0136079957790962 no 76 0.0106088780616384 114 2997347
SGTC_1378 2093-0007 380 nM 2.30053595255772 0.0137281614091018 no 77 0.0107089374275527 167 3618014
SGTC_673 1082-0474 110 µM 2.29618345451517 0.0138766922375268 no 78 0.0108326970809443 231 3098046
SGTC_1839 st053978 48 µM 2.29398729018932 0.0139521618579751 no 79 0.0108956144032807 147 3788398
SGTC_2332 7982454 138.89 µM 2.2852127609969 0.0142572339455657 no 80 0.0111501776531118 218 2981748
SGTC_2662 daunorubicin 22.37 µM 2.28317333578817 0.0143289578623963 no 81 0.0112100800514439 135 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 2.26137332163763 0.0151152506988586 no 82 0.0118680746746406 186 23847180
SGTC_2019 4016004 108 µM 2.26096972039681 0.0151301507767852 no 83 0.0118805660762185 159 45595336
SGTC_2966 9084041 48.03 µM 2.26093543800408 0.0151314169893109 no 84 0.0118816276368032 173 17741380
SGTC_18 0111-0177 500 nM 2.25150811575607 0.0154830859831877 no 85 0.0121766867250535 252 721752
SGTC_2793 7325131 81.82 µM 2.24578284575546 0.0157000626969734 no 86 0.0123589603053501 139 4176441
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 2.23866543138987 0.0159734315938972 no 87 0.0125888466910436 171 5024745
SGTC_2424 5537928 59.2 µM 2.23597434115696 0.0160778500885213 no 88 0.0126767259856105 194 5382802
SGTC_2047 4141938 200 µM 2.22233222175642 0.0166162297101857 no 89 0.0131304310591737 114 3807862
SGTC_1510 1123-0200 71.5 µM 2.21780456540955 0.0167982883168901 no 90 0.0132840803554138 221 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_3130 9127414 49.47 µM 2.21350668818304 0.016972683231376 no 91 0.0134313663235869 129 1494646
SGTC_2158 5657123 3.6195 µM 2.21219431205582 0.0170262430377319 no 92 0.0134766208496774 117 2858827
SGTC_1287 0971-0001 34.6 µM 2.20560784418876 0.017297232702797 no 93 0.0137057346883956 214 4665869
SGTC_3276 9139060 49.47 µM 2.2054583224612 0.0173034270583836 no 94 0.013710974654851 103 4870619
SGTC_1784 st039334 36.3 µM 2.19178556655386 0.0178779250328132 no 95 0.0141974968947775 165 3496984
SGTC_1374 2889-5571 141 µM 2.1663921822734 0.0189881174810755 no 96 0.0151406154244596 229 2853281
SGTC_1850 st056238 17 µM 2.16044148670556 0.0192565988419198 no 97 0.0153692543674107 180 5393177
SGTC_1376 2910-0861 41.3 µM 2.15810885091394 0.0193627186348586 no 98 0.0154596848871396 203 1112859
SGTC_3210 9128157 49.47 µM 2.14197445317028 0.0201104189146136 no 99 0.0160977689181148 228 17590849
SGTC_2516 gossypol 71.55 µM 2.13887735700472 0.0202567113152989 no 100 0.0162228011552674 190 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3037 9091026 49.47 µM 2.12541682598832 0.0209030491436431 no 101 0.0167759237575802 355 25236398 YIL048W NEO1
SGTC_1240 0356-0016 42.1 µM 2.1060585488041 0.0218631267068604 no 102 0.01759963343387 200 4305613
SGTC_2824 7998404 51.95 µM 2.09833335741015 0.022256522479127 no 103 0.0179378538946794 180 837851
SGTC_2178 5812956 200 µM 2.09311707172854 0.0225255196284707 no 104 0.0181693525574987 182 5403383
SGTC_740 k014-0057 261 µM 2.09223954255353 0.0225710409803866 no 105 0.0182085464342511 214 4012779
SGTC_2197 6588183 93.1375 µM 2.08307765129865 0.0230509583543248 no 106 0.0186220730622635 147 884136
SGTC_3145 9085516 49.47 µM 2.07789671559454 0.0233261294327331 no 107 0.0188594365538411 202 25236195
SGTC_1799 st045822 46.1415 µM 2.07314549328542 0.0235809025087328 no 108 0.0190793706289231 171 3674992
SGTC_799 1310-0557 151 µM 2.06775720183016 0.0238726651998293 no 109 0.0193314300054966 209 5354492
SGTC_2878 9043973 25.97 µM 2.06764046751946 0.0238790195049248 no 110 0.0193369218970258 165 6465167
SGTC_610 4215-0184 155 µM 2.05694259540688 0.0244674115758103 no 111 0.0198458740098234 211 5605015
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 2.04659100149889 0.0250482958906714 no 112 0.0203491295572066 269 551469
SGTC_2291 7917025 104.35 µM 2.0384886559506 0.02551098904318 no 113 0.0207505440493812 263 2964612
SGTC_513 4245-1575 41.7 µM 2.03750746591156 0.0255675037531123 no 114 0.0207996072711 371 719745
SGTC_1417 3966-0327 90.4 µM 2.03379807408365 0.0257821059067638 no 115 0.0209859794029087 219 651118
SGTC_3293 9120939 62.045 µM 2.03299540277816 0.0258287412943541 no 116 0.0210264937313422 191 934087
SGTC_27 0485-0001 32.618 µM 2.0276629529982 0.0261403532812621 no 117 0.0212973295801149 118 2054479
SGTC_2456 5770359 74.46 µM 2.02681556068877 0.026190160607241 no 118 0.0213406392451146 195 3118787
SGTC_1756 st041558 35.5 µM 2.02609841048922 0.0262323746413825 no 119 0.021377350481551 202 3955792
SGTC_888 0916-0002 6.97 µM 2.00777037069921 0.0273306850432665 no 120 0.0223338493773579 210 2802138 YIL048W NEO1
SGTC_2880 9042983 58.44 µM 1.99898982710414 0.0278702969311448 no 121 0.0228047272820474 216 6464714
SGTC_3087 9117406 49.47 µM 1.99279521973759 0.028256304835453 no 122 0.0231419377156819 203 42546093
SGTC_875 0709-0210 25.7 µM 1.9859711070617 0.0286866802727392 no 123 0.0235182660985734 247 6251364
SGTC_3336 9143619 71.43 µM 1.9826432536276 0.0288985267870442 no 124 0.0237036461574451 222 45595730
SGTC_637 1181-0519 7.26 µM 1.95061055172913 0.0310049472817975 no 125 0.0255516955244057 360 6252091 YGR060W ERG25
SGTC_2749 bexarotene 57.39 µM 1.94518669485973 0.031373892167305 no 126 0.0258762563003027 280 82146 An retinoic acid receptor inhibitor.
SGTC_220 paclitaxel 373.376 µM 1.94228340742198 0.0315728683094269 no 127 0.0260514002912715 170 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1682 st012968 530 nM 1.94118478979583 0.0316484333202403 no 128 0.0261179336805612 199 24207270
SGTC_1940 st075990 51.1 µM 1.94052421130745 0.0316939410710264 no 129 0.026158007344929 270 1084979
SGTC_23 0213-0011 39.996 µM 1.93736624524876 0.0319122434521118 no 130 0.0263502948667495 235 627608
SGTC_1594 piperine 70.1 µM 1.93536331507311 0.0320513435925061 no 131 0.0264728638647788 259 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2152 5568786 200 µM 1.92674784296484 0.0326553933947391 no 132 0.0270055311667705 223 5399883
SGTC_2630 antimycin a 100 µM 1.92593056299503 0.0327131790280491 no 133 0.0270565223069787 281 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_41 0478-0632 82.643 µM 1.92238926923431 0.0329645405592403 no 134 0.0272783974036606 289 3750424
SGTC_2138 5575593 77.673 µM 1.91319278192901 0.0336247502284621 no 135 0.0278616886171786 197 762213
SGTC_2007 4011539 71.82 µM 1.91207546293651 0.0337056981147594 no 136 0.0279332577803974 265 45595301
SGTC_2478 5763493 32.33 µM 1.91175193672669 0.0337291669617421 no 137 0.0279540096140334 227 1365576 YLR208W SEC13
SGTC_752 1896-0090 130 µM 1.90768226360257 0.034025534287135 no 138 0.0282161477375603 240 772567
SGTC_173 1273-0061 2.693 µM 1.9021675422478 0.0344305486208967 no 139 0.0285746273396195 388 2847414 YPL266W DIM1
SGTC_2266 7929956 200 µM 1.90096439137184 0.0345194352455518 no 140 0.0286533384395123 264 2967153
SGTC_1550 gossypolone 36.6 µM 1.89978775601278 0.03460654519406 no 141 0.0287304891864647 269 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1198 1612-1005 86.7 µM 1.89866579124115 0.034689775797391 no 142 0.0288042160419809 226 6998509
SGTC_1753 st043925 64 µM 1.89398297770434 0.0350389372318822 no 143 0.0291136346704126 251 670181
SGTC_170 4197-0004 226 µM 1.89308731003084 0.0351060477652473 no 144 0.0291731297329622 208 218692
SGTC_371 0195-0006 7.36 µM 1.88958781395188 0.0353692696028332 no 145 0.0294065541093544 210 3928593
SGTC_1366 1683-0113 21.9 µM 1.88764960961899 0.0355157507501924 no 146 0.0295365026812195 226 708623
SGTC_3063 1327-0034 4 µM 1.88739498245831 0.0355350312856184 no 147 0.0295536097477398 251 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1307 1187-1599 12.2 µM 1.88673531411871 0.0355850217201716 no 148 0.0295979676676044 239 1538471
SGTC_2774 tamoxifen 10.92 µM 1.88527639256514 0.0356957852445882 no 149 0.0296962658399109 241 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_476 mead acid 10 µM 1.88318214242421 0.0358552776488632 no 150 0.0298378441237731 156 5312531 An omega 9 fatty acid.
SGTC_876 0720-0963 56.8 µM 1.87981385242152 0.0361130217983884 no 151 0.0300667259407671 240 765861
SGTC_132 0417-1715 25.805 µM 1.87981233911913 0.0361131379375317 no 152 0.0300668290988284 247 6769098
SGTC_611 3453-1652 23.7 µM 1.87397280582196 0.0365635788756816 no 153 0.0304670867007528 301 1560575
SGTC_743 1275-0778 158 µM 1.87274472779732 0.0366588910722881 no 154 0.0305518218698096 289 2849257 YMR203W TOM40
SGTC_1065 prochlorperazine maleate 2.48 µM 1.86577713678626 0.0372035063140853 no 155 0.0310362761766363 272 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2956 9076196 2.52 µM 1.85217959771237 0.0382853838013076 no 156 0.0320000187372615 266 16423868
SGTC_1621 st003705 32.4 µM 1.84905168403261 0.038537848891275 no 157 0.0322251750390082 294 24207032
SGTC_2782 7736369 71.43 µM 1.84556329747504 0.0388210076192339 no 158 0.0324778199050814 314 2950836 YOL077C BRX1
SGTC_1304 1165-0502 251 µM 1.84389457251891 0.0389570590528287 no 159 0.032599253119766 318 767425
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 1.84350057603329 0.0389892382461063 no 160 0.0326279788458111 285 6708784 An antioxidant flavonoid
SGTC_2833 9001315 45.46 µM 1.83884679664921 0.0393709701573754 no 161 0.0329688614985031 319 2989378
SGTC_2750 bromebric acid 70.15 µM 1.83250806649153 0.0398957981078538 no 162 0.0334378805337115 319 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_3022 9087993 49.47 µM 1.82773019992554 0.040295138097452 no 163 0.0337950266835407 219 17173644
SGTC_504 lovastatin 124 µM 1.82153350055031 0.0408178950389049 no 164 0.0342628995328719 227 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1822 st052468 42 µM 1.8191893818636 0.0410170750277319 no 165 0.0344412711109752 240 2873678
SGTC_1505 k297-0037 20.6 µM 1.8162052810055 0.0412717740580756 no 166 0.0346694441508006 285 4089396
SGTC_2202 7226349 200 µM 1.78997224983789 0.0435664061187813 no 167 0.0367291863151826 227 844334
SGTC_663 1486-0733 13.9 µM 1.78948093900014 0.0436103444145726 no 168 0.0367686972650701 353 722445 YPR165W RHO1
SGTC_2145 5634607 200 µM 1.78675158936049 0.0438550837389251 no 169 0.0369888234377822 225 308662
SGTC_989 1501-0895 10.3 µM 1.78137608657056 0.0443403415414887 no 170 0.0374255160735354 242 2830112
SGTC_223 busulfan 5 mM 1.78003185255394 0.0444623622466081 no 171 0.0375353739987564 192 2478 A DNA alkylator.
SGTC_2887 9044784 58.44 µM 1.77910925469478 0.0445462660587451 no 172 0.03761092585942 311 6465546
SGTC_1407 3909-7909 12.3 µM 1.76689775165645 0.045668877896489 no 173 0.0386226768194149 312 4411780
SGTC_1896 st058441 89 µM 1.7656357223783 0.0457861823948027 no 174 0.0387284914459565 267 688759
SGTC_2540 epiandrosterone 100 µM 1.763986184915 0.0459398704089587 no 175 0.0388671525780208 412 441302 A steroid.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.75398086043958 0.0468809721878286 no 176 0.0397168933785347 312 115019
SGTC_2057 5236571 38.335 µM 1.75188825290732 0.0470797450115053 no 177 0.0398965124350242 362 54684039 YBR257W POP4
SGTC_1994 st072947 40.9 µM 1.74859346918164 0.0473940791832178 no 178 0.040180658003501 309 5286565 YDL195W SEC31
SGTC_1664 st014217 9.02 µM 1.7474195181752 0.0475064838161505 no 179 0.040282297123583 309 3982782
SGTC_1993 st073995 70.8 µM 1.74642949908162 0.0476014430625124 no 180 0.0403681738763103 287 3098394
SGTC_814 3342-0569 96 µM 1.74632887894592 0.0476111027070561 no 181 0.0403769102371714 340 4346283
SGTC_1853 st056710 91.2 µM 1.73660676027695 0.0485518658242193 no 182 0.0412283027271639 297 269167
SGTC_1126 isoteolin 1.0172 µM 1.736050757574 0.0486061136964411 no 183 0.0412774300753303 313 133323
SGTC_2258 7960471 200 µM 1.73302508047967 0.0489021717590654 no 184 0.0415456055479829 228 2974708
SGTC_1902 st060212 70.5 µM 1.73228549741429 0.0489747575876704 no 185 0.0416113714132981 312 688944
SGTC_933 2914-0560 114 µM 1.73214826429895 0.0489882356925345 no 186 0.0416235838502994 344 463887
SGTC_1914 st062367 72.6 µM 1.73155471254906 0.0490465644449949 no 187 0.0416764377296066 288 978205
SGTC_2110 5483698 200 µM 1.72520473001126 0.0496740593012493 no 188 0.042245291790135 289 2848765 YHR062C RPP1
SGTC_435 c-PAF 6.7 µM 1.72105765591625 0.0500873126670752 no 189 0.0426201810408903 349 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_3268 9137683 49.47 µM 1.71657598932463 0.0505369848618149 no 190 0.0430283363374399 228 1953228
SGTC_1193 1488-0126 41.5 µM 1.71621976463918 0.0505728645307568 no 191 0.0430609135261849 349 1384710
SGTC_1080 nisoldipine 24.4 µM 1.71417769490974 0.0507789376493578 no 192 0.0432480480259982 332 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1111 tnp00062 510.699 nM 1.71338537745182 0.0508590732746826 no 193 0.043320832312183 290 676306
SGTC_2264 7948757 110.76 µM 1.71243702800895 0.050955122445691 no 194 0.0434080800985847 315 2971411
SGTC_1772 st048439 82.2 µM 1.71018398872736 0.0511838901052267 no 195 0.0436159277616359 355 2927068 YDL195W SEC31
SGTC_899 1083-0020 478 µM 1.70671359919871 0.0515378623343268 no 196 0.0439376491481183 344 767123
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 1.7053046909819 0.051682122311894 no 197 0.0440688065827036 354 688667
SGTC_1112 tnp00069 1.16933 µM 1.70166319624848 0.0520564670504043 no 198 0.0444092616860855 360 145826
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 1.70157773073663 0.052065278685772 no 199 0.0444172775157196 370 676296 Flavone; oxidizing agent.
SGTC_1114 scopoletin 1.73284 µM 1.69294058699646 0.0529619098850094 no 200 0.0452333883792649 294 5280460 A coumarin with genotoxic properties.
SGTC_1857 st056007 79.3 µM 1.68593068296398 0.0536985819204488 no 201 0.0459045756369676 276 619834
SGTC_2772 vinpocetine 57.06 µM 1.68495812189722 0.0538014265657686 no 202 0.0459983257611632 342 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1995 st072814 61.1 µM 1.68412204285052 0.0538899633819796 no 203 0.0460790425858451 316 5769371
SGTC_2338 7999974 200 µM 1.68310897605374 0.0539973968935617 no 204 0.0461769985855317 343 315925
SGTC_1442 4112-3290 3 µM 1.68126512623373 0.0541933681694283 no 205 0.0463557142447335 343 704353
SGTC_2001 4023502 57.655 µM 1.67595084163387 0.0547613400736254 no 206 0.0468739109475822 354 108941 YCR052W RSC6
SGTC_556 4058-0063 51.5 µM 1.67218217936588 0.0551669654800118 no 207 0.0472442017221072 350 6615692
SGTC_2092 5303694 80.6725 µM 1.67089943866345 0.0553055684561636 no 208 0.0473707712131106 366 1963699
SGTC_1267 0828-0272 9.49 µM 1.67055848569823 0.0553424554055064 no 209 0.047404459101534 363 745334
SGTC_2300 7976697 71.57 µM 1.67034431069047 0.0553656364606043 no 210 0.0474256304971549 289 2236109
SGTC_1622 st003707 19.4 µM 1.66662873459723 0.05576901030202 no 211 0.0477941257658288 392 10140899
SGTC_3099 9120367 49.47 µM 1.65852254847948 0.0566570887053843 no 212 0.0486060200846082 325 24824940
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.65615972005593 0.0569180362004031 no 213 0.0488447389873143 365 5377381
SGTC_1686 st019653 115.5 µM 1.65557941474729 0.0569822688525209 no 214 0.0489035108866588 315 97252
SGTC_2937 9044753 11.33 µM 1.65273241560478 0.0572982238311621 no 215 0.0491926670626195 400 6465530 YGL099W LSG1
SGTC_847 0342-0274 5.54 µM 1.65205539884429 0.0573735604853712 no 216 0.049261628999786 336 18097
SGTC_1100 amiodarone 5.07 µM 1.65202320304413 0.0573771450901326 no 217 0.0492649104338956 372 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2135 5326629 150.42 µM 1.64564833340389 0.0580903863946565 no 218 0.0499180909961404 334 5020077
SGTC_1677 st019204 53.9 µM 1.63960381059738 0.0587730844342576 no 219 0.0505437851412354 335 3945625
SGTC_1492 4158-0558 28.5 µM 1.63835133304885 0.0589153298486093 no 220 0.0506742125404391 332 3967268
SGTC_2690 usnic acid 100 µM 1.63570942611773 0.0592162601983813 no 221 0.0509502078803731 414 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2089 5281248 129.67 µM 1.63131728883068 0.0597192193800394 no 222 0.0514116935973883 355 2737878
SGTC_3161 9100388 49.47 µM 1.62825493110311 0.0600718768120071 no 223 0.0517354207790921 309 25236368
SGTC_1148 3909-7663 27.7 µM 1.61913693278365 0.061131554862646 no 224 0.0527089019394053 363 4084526
SGTC_48 0382-0018 55 µM 1.61780782523134 0.0612872340083375 no 225 0.0528520097330309 314 762596
SGTC_2440 5628896 157.78 µM 1.60934332513393 0.062285964806004 no 226 0.053770645238885 333 5522048
SGTC_149 3970-0822 46.1 µM 1.60579837263842 0.0627079881151669 no 227 0.0541591091675185 529 3114250 YBL034C STU1
SGTC_3092 9117248 49.47 µM 1.60486669966517 0.0628192719020955 no 228 0.0542615716917082 310 17141857
SGTC_1268 0828-0275 2.46 µM 1.60146103659102 0.0632273714739393 no 229 0.0546374216311954 357 745337
SGTC_698 k064-0052 127 µM 1.59926249405658 0.0634919166547809 no 230 0.0548811447511566 281 5088751
SGTC_3349 9149703 23.001 µM 1.59906832359434 0.0635153220437928 no 231 0.0549027110727294 345 4910494
SGTC_3051 9093778 49.47 µM 1.59339495487881 0.0642021609140408 no 232 0.0555358084024577 275 17217378
SGTC_986 1493-0483 84 µM 1.59004466135582 0.0646104627388887 no 233 0.0559123691755138 344 40079
SGTC_944 3370-0224 231 µM 1.58828725720709 0.064825443358507 no 234 0.0561106988212558 373 4580514
SGTC_440 fluspirilene 35.1 µM 1.58454139281747 0.0652855225078411 no 235 0.0565352849285411 393 3396 An atypical antipsychotic.
SGTC_1443 4112-3303 14 µM 1.58427840501099 0.0653179184449636 no 236 0.0565651889143195 382 704433
SGTC_646 4092-0839 27.3 µM 1.58354023724884 0.0654089156624898 no 237 0.0566491915563446 365 877796
SGTC_3233 9132340 49.47 µM 1.58103272274724 0.0657187625612113 no 238 0.0569352779701741 372 17682950
SGTC_3146 9095609 49.47 µM 1.57984926877777 0.0658653934890287 no 239 0.0570706947415612 355 17173999
SGTC_1242 0402-0103 60.1 µM 1.57666605050058 0.0662610551332507 no 240 0.0574361929863704 359 432868
SGTC_488 nitrendipine 139 µM 1.5750732240235 0.0664597270184764 no 241 0.0576197718670097 387 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1863 st057641 20.1 µM 1.57472960665189 0.0665026465337191 no 242 0.0576594354311546 406 3921635
SGTC_804 1595-0054 20.9 µM 1.57014288472689 0.0670776077158473 no 243 0.0581909367900948 369 761523 Stimulates phospholipase C.
SGTC_2327 6189656 200 µM 1.56832060076718 0.0673071013907013 no 244 0.0584031652751844 347 5349088
SGTC_2849 9019321 12.99 µM 1.56625983818155 0.0675673592368356 no 245 0.0586438995639355 365 16489627
SGTC_285 1486-1325 46 µM 1.55764995414078 0.0686631371440346 no 246 0.0596581250113814 408 22310230
SGTC_1352 1496-0991 99 µM 1.55489150258609 0.069017088269295 no 247 0.0599859557380732 388 3000039
SGTC_208 k072-0098 12.366 µM 1.55037038452211 0.0696002552757128 no 248 0.0605263212833956 486 5948901
SGTC_1751 st044839 27.194 µM 1.55031107862135 0.0696079301179411 no 249 0.0605334347670042 325 5291326
SGTC_2765 myclobutanil 7.74 µM 1.54690179332828 0.0700502258087442 no 250 0.0609434642857307 403 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_3193 9111931 49.47 µM 1.54352004433533 0.070491081995048 no 251 0.0613523239771312 399 17087244
SGTC_2253 7938677 135.83 µM 1.54308421951871 0.070548052392299 no 252 0.0614051715141716 371 2301972
SGTC_1392 3455-1037 33.9 µM 1.53682910900437 0.0713696156759415 no 253 0.0621675815606173 400 981132
SGTC_2721 ifenprodil 61.44 µM 1.5341919965425 0.0717181739038743 no 254 0.0624912130093708 390 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_101 0490-5701 117.494 µM 1.52789499500419 0.0725557556639586 no 255 0.0632693055370423 343 4661669
SGTC_2702 st077768 96.8 µM 1.52767521423708 0.0725851240642899 no 256 0.0632965984847439 380 6484119
SGTC_3074 9116018 49.47 µM 1.52712138813483 0.0726591699482899 no 257 0.0633654147025586 361 17027303
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.52566926750891 0.0728535914073242 no 258 0.0635461259614738 417 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1187 1391-0724 117 µM 1.52284964566302 0.0732322419511281 no 259 0.0638981630437474 448 6997986
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.52114771770689 0.073461523578737 no 260 0.0641113860533527 474 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1619 st003326 88.7 µM 1.52112620873565 0.0734644247495414 no 261 0.0641140843015623 366 2849032
SGTC_3294 9122953 26.2835 µM 1.50881500683146 0.0751394040093163 no 262 0.065673032319641 415 16459826
SGTC_1643 st009866 20.2 µM 1.50625109928766 0.075491867543387 no 263 0.0660013631142677 356 3156273 YOR207C RET1
SGTC_78 0336-0123 156.75 µM 1.50577937856983 0.0755568525793171 no 264 0.0660619093705507 375 6765896
SGTC_1146 3579-1023 7 µM 1.50356345953739 0.0758626918242113 no 265 0.066346902819895 473 X1146
SGTC_3057 9095946 49.47 µM 1.50093273721775 0.0762270048380663 no 266 0.0666864798752326 397 24540043
SGTC_771 0250-0039 27.3 µM 1.49992490715962 0.0763669254253285 no 267 0.0668169276607631 426 3005115
SGTC_1920 st075728 45.7 µM 1.49963078139786 0.076407796754061 no 268 0.0668550348179498 408 3400306
SGTC_1448 4255-0083 152 µM 1.49850074816719 0.076564979497039 no 269 0.067001599195411 421 5399660
SGTC_2120 5538279 151.968 µM 1.48956332983262 0.0778168122698512 no 270 0.0681695449862683 414 2058197
SGTC_605 1315-0399 119 µM 1.48841224115852 0.0779791639632228 no 271 0.0683211051502324 463 24020461
SGTC_2159 5658611 73.75 µM 1.48554439436893 0.078384768097156 no 272 0.0686998362305896 387 793844
SGTC_98 0074-0023 107.663 µM 1.4841963417987 0.0785759771155254 no 273 0.0688784200097982 458 3563821
SGTC_1777 st045864 34.765 µM 1.48416294416318 0.0785807187508271 no 274 0.0688828489129829 431 4691462
SGTC_758 0868-0029 16 µM 1.47697589807464 0.0796061541310262 no 275 0.0698410490402507 433 762687
SGTC_552 k242-0005 476 µM 1.47165313302407 0.0803720995025597 no 276 0.0705572848102777 392 4088318
SGTC_3150 9097574 49.47 µM 1.46922854956722 0.0807228373041708 no 277 0.0708854045611375 382 17217476
SGTC_2992 9074591 71.4286 µM 1.46613491189278 0.0811720365145686 no 278 0.0713057681455906 412 17741321
SGTC_322 k048-0136 19.3 µM 1.46508189248671 0.0813253654485185 no 279 0.071449288155425 411 6823282
SGTC_3023 9089636 49.47 µM 1.45988984686939 0.082084569006163 no 280 0.0721601750451096 430 17249241
SGTC_792 4534-1957 155 µM 1.45546938329438 0.0827351462584328 no 281 0.0727696801371253 422 1717904
SGTC_2756 carbadox 75.1 µM 1.45356478211873 0.0830166470802035 no 282 0.0730335034401937 485 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1933 st074711 15.9 µM 1.45349557069578 0.083026890104508 no 283 0.0730431042975327 493 17250958
SGTC_1888 azatryptophan 97.5 µM 1.44650044417656 0.0840670520394912 no 284 0.0740184437607704 399 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_998 3996-0085 177 µM 1.44090393184096 0.0849062635590229 no 285 0.0748059125706975 499 715391
SGTC_2190 6049624 200 µM 1.43951638151368 0.0851152986473868 no 286 0.0750021360130966 384 2265554
SGTC_1959 st077091 55.8 µM 1.43686576826701 0.0855156864158179 no 287 0.0753780691505498 487 821356 YKL052C ASK1
SGTC_849 0386-0493 241 µM 1.4345698166178 0.0858636394505841 no 288 0.0757048604073467 434 726119
SGTC_2314 7727897 200 µM 1.43403549192573 0.0859447685049728 no 289 0.075781067391885 444 900724
SGTC_344 k064-0035 6.43 µM 1.43146570238223 0.086335753355402 no 290 0.076148394922668 446 5088750
SGTC_2361 9034121 116 µM 1.43127137317011 0.0863653739005548 no 291 0.0761762275009022 439 6496917
SGTC_709 3807-1509 243 µM 1.42824289896965 0.0868279702561424 no 292 0.0766109784512672 410 1886677 YPL242C IQG1
SGTC_413 propylparaben 100 µM 1.42725745781583 0.0869788939050375 no 293 0.0767528490883137 431 7175 A pharmaceutical preservative.
SGTC_71 0417-1750 47.813 µM 1.42528279963104 0.0872819091054521 no 294 0.077037735055809 496 6811472
SGTC_1636 st007707 68.9 µM 1.42333738961228 0.0875812061375502 no 295 0.0773191865291116 514 403051
SGTC_1177 0983-0204 23.6 µM 1.41666539858091 0.0886134948515337 no 296 0.078290389007541 502 766818
SGTC_1373 2887-0003 58.5 µM 1.41636884396871 0.0886595871771167 no 297 0.0783337704815602 463 776948
SGTC_3309 9129340 25.759 µM 1.41378466822508 0.0890619915247422 no 298 0.0787125682642307 482 17158987
SGTC_1097 itavastatin 7.23 µM 1.41238885278596 0.0892799106534752 no 299 0.0789177484440389 477 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2726 cimetidine 79.27 µM 1.40766775641219 0.0900199233290101 no 300 0.0796147368725779 393 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_3212 9128307 49.47 µM 1.40711173579062 0.0901073764200551 no 301 0.0796971293313884 432 27243542
SGTC_1730 st033808 45.1 µM 1.40628700469622 0.0902372095647502 no 302 0.0798194587211311 552 1045166
SGTC_1953 st076800 12.1 µM 1.40591413761844 0.090295953688168 no 303 0.079874811344866 506 297591
SGTC_2553 4-methylesculetin 85.09 µM 1.4041210310317 0.0905788491646966 no 304 0.0801414059866032 488 5319502
SGTC_2259 7964009 200 µM 1.4027649857542 0.0907932267302108 no 305 0.0803434656991957 434 313134
SGTC_2741 miltefosine 3.04 µM 1.40238369320045 0.0908535731348912 no 306 0.0804003500925701 383 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_2044 5102272 200 µM 1.4007621377512 0.0911105458776821 no 307 0.080642607148063 422 592666
SGTC_3002 9075603 71.4286 µM 1.39762624982198 0.091609027940915 no 308 0.0811126657196019 500 20105405
SGTC_1023 4482-3888 16 µM 1.39392566145665 0.0921998711717441 no 309 0.0816700271138874 459 3303168
SGTC_2356 9061756 188.97 µM 1.3936777174699 0.0922395589952798 no 310 0.0817074739699137 445 20104043
SGTC_349 k015-0014 24 µM 1.39188080122432 0.0925275652118675 no 311 0.0819792482416385 467 2196908
SGTC_1608 st001473 40.5 µM 1.38962329044253 0.0928903368694092 no 312 0.0823216497672652 480 7292267
SGTC_2512 diallyl trisulfide 49.23 µM 1.3885353516568 0.0930655386954128 no 313 0.0824870438481486 422 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_589 1227-0070 34.1 µM 1.38600802587719 0.093473482127749 no 314 0.0828722263921619 482 2841384
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.38513487958546 0.0936147258820382 no 315 0.0830056141669585 378 279621
SGTC_3066 9117245 49.47 µM 1.3845429906999 0.0937105618615873 no 316 0.0830961269387934 495 17176980
SGTC_1412 3909-8563 178 µM 1.37568075547264 0.0951541671216221 no 317 0.0844602462839933 540 23767530
SGTC_2925 9010536 32.5 µM 1.37542222773723 0.0951965242316625 no 318 0.0845002908705841 573 2994177
SGTC_1422 4031-0024 15.5 µM 1.36777575650401 0.0964556056582218 no 319 0.0856911392546267 485 782427
SGTC_3317 9138495 8.753 µM 1.3654034917185 0.0968487029443197 no 320 0.0860631335255437 522 17020139
SGTC_1195 1502-0147 41.1 µM 1.36497218907943 0.0969202983539993 no 321 0.0861308955940082 536 817940
SGTC_3182 9108849 49.47 µM 1.36378769497425 0.0971171219813305 no 322 0.0863171970794586 538 17133045
SGTC_3152 9099253 49.47 µM 1.3607433598009 0.0976243350766459 no 323 0.0867974034432809 618 25236131
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.36031408446737 0.097696012109649 no 324 0.086865276611316 543 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_691 1548-0686 185 µM 1.35904924603272 0.0979074292433159 no 325 0.0870654920702436 520 46495133
SGTC_2434 5670830 169.91 µM 1.35903197406545 0.0979103185631936 no 326 0.087068228490459 515 1549830
SGTC_1103 duloxetine 36.1 µM 1.35748316633114 0.0981696630817753 no 327 0.087313869325276 566 60835 A selective serotonin reuptake inhibitor.
SGTC_3227 9130768 49.47 µM 1.35581644746813 0.0984493133473661 no 328 0.0875787884089839 470 17720899
SGTC_960 1222-0186 7.7 µM 1.35495867422808 0.0985934618896445 no 329 0.0877153619932141 529 3126296
SGTC_2781 5567276 71.43 µM 1.35487356598154 0.0986077727266483 no 330 0.0877289214816497 500 2853274
SGTC_1824 st053723 68.6 µM 1.35486287668508 0.0986095702249227 no 331 0.0877306246162361 506 675225
SGTC_1841 st054148 70 µM 1.35146201836855 0.0991826725844837 no 332 0.0882737394008844 469 675442
SGTC_122 0236-0016 402.397 µM 1.35120467683982 0.0992261379238043 no 333 0.0883149384291033 578 6808838
SGTC_2508 celastrol 40.54 µM 1.35100750699961 0.0992594496047217 no 334 0.0883465139802326 444 122724 Celastrol is a natural product and antioxidant.
SGTC_2195 6536160 144.242 µM 1.35089156967712 0.0992790409364341 no 335 0.0883650845649377 436 3834386
SGTC_374 0880-0231 82.3 µM 1.35067420078767 0.0993157800061872 no 336 0.0883999100736944 522 6833587
SGTC_3003 9075612 71.4286 µM 1.3498102039361 0.0994619085651221 no 337 0.088538435461552 503 6501993
SGTC_966 1300-0360 30.2 µM 1.33868215091278 0.101358070865389 no 338 0.0903370846950344 520 70588
SGTC_1713 st033146 12.748 µM 1.3373407592926 0.101588403668318 no 339 0.0905557160663592 531 674619
SGTC_407 eburnamonine 100 µM 1.33683015840463 0.101676179962438 no 340 0.0906390412607488 451 3195
SGTC_1835 st008666 49.2 µM 1.33560420242294 0.101887156836021 no 341 0.0908393379174783 443 690455
SGTC_1821 st053465 65.6 µM 1.33485460588364 0.102016313063201 no 342 0.0909619686687952 486 675086
SGTC_3221 9128209 49.47 µM 1.3345201354679 0.102073981070671 no 343 0.0910167261889741 475 16460723
SGTC_2816 7982706 58.44 µM 1.3338385456423 0.102191571380468 no 344 0.0911283877225023 522 2981853
SGTC_2652 actinonin 100 µM 1.33372311866819 0.10221149500733 no 345 0.0911473076150498 474 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_742 0kpi-0133 140 µM 1.33221817990747 0.102471518197174 no 346 0.091394252123681 544 2728852
SGTC_224 benfluorex 43.875 µM 1.33097208364062 0.102687182325448 no 347 0.0915990983693093 404 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1024 4507-0395 26 µM 1.32947065505688 0.102947475257225 no 348 0.0918463704857854 525 4201836
SGTC_1463 k081-0032 34.1 µM 1.32780743230271 0.103236376607268 no 349 0.0921208655056508 421 977755
SGTC_760 0568-0725 82.9 µM 1.32613656830341 0.10352719753621 no 350 0.0923972326865045 531 3916171
SGTC_1723 st034307 2.5525 µM 1.32478046615198 0.103763669585073 no 351 0.0926219877455881 515 867466
SGTC_925 2064-1272 59.6 µM 1.32436132672319 0.103836836768277 no 352 0.0926915360175898 509 6815817
SGTC_641 4092-0595 30 µM 1.32373186124571 0.103946789863494 no 353 0.0927960564730732 550 786260
SGTC_2622 2-methoxyxanthone 59.94 µM 1.32344411868083 0.103997079961289 no 354 0.092843864095619 542 71034 A hepatoprotective.
SGTC_3170 9103054 49.47 µM 1.31583994388829 0.105332496853789 no 355 0.0941138846934422 482 16432970
SGTC_444 curcumin 90.4 µM 1.31467283553452 0.105538553308175 no 356 0.0943099399026093 558 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2114 5491910 81.25 µM 1.31408080961749 0.105643188617291 no 357 0.094409505696847 538 2849228
SGTC_2387 9077560 195.08 µM 1.31374201371754 0.105703101509919 no 358 0.0944665186067914 536 5303272
SGTC_894 0960-0238 55.9 µM 1.31158983780981 0.106084267458379 no 359 0.0948292818320648 541 6741907 YDL195W SEC31
SGTC_3082 9117008 49.47 µM 1.31109362398314 0.106172291223756 no 360 0.0949130673221001 534 41448529
SGTC_457 grayanotoxin iii 135 µM 1.31075685335215 0.106232061281056 no 361 0.0949699619576389 616 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_375 3970-0961 9.27 µM 1.30948494747123 0.106458018382331 no 362 0.095185066655504 545 2898222
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.30707992036387 0.106886225184975 no 363 0.0955927850100622 541 97141
SGTC_401 neomycin 50 µM 1.30458749871917 0.107331302025949 no 364 0.0960166736909793 500 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1121 fusaric acid 630.51 nM 1.30450631834041 0.1073458210058 no 365 0.0960305033255969 555 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2871 9038510 12.99 µM 1.30426665245816 0.107388693122314 no 366 0.0960713405983774 572 4945164
SGTC_2826 7992541 19.48 µM 1.30315843811504 0.107587094149156 no 367 0.0962603380631941 516 2985066
SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.30179791982679 0.107831025557382 no 368 0.0964927375501982 602 165506
SGTC_35 0133-0054 64.071 µM 1.30166059523028 0.107855669011962 no 369 0.0965162177940027 518 99677
SGTC_3241 9133421 49.47 µM 1.29975177183928 0.108198635229136 no 370 0.0968430299598377 472 17018221
SGTC_3275 9138069 49.47 µM 1.29695817024427 0.108701987258834 no 371 0.097322789879284 514 17617007
SGTC_257 daunorubicin 18.5 µM 1.29632859373135 0.108815656708228 no 372 0.0974311507269282 501 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_315 k915-0449 187 µM 1.29558813872017 0.108949454504291 no 373 0.097558708873992 637 20970215 YNL149C PGA2
SGTC_1042 0350-0096 82 µM 1.29413717131114 0.109211982403758 no 374 0.0978090220079844 541 3122515
SGTC_1039 k821-0043 94 µM 1.29384100204387 0.109265625011556 no 375 0.0978601733500968 567 15992768
SGTC_1278 0874-0585 172 µM 1.29276183296778 0.109461245828551 no 376 0.0980467223374151 555 766306
SGTC_1620 st003704 16.5 µM 1.29248313638426 0.109511805958283 no 377 0.0980949411236407 550 2834414
SGTC_598 3937-0236 20.2 µM 1.29073911775242 0.109828580407522 no 378 0.0983970777098984 612 1379313
SGTC_1232 0279-0259 161 µM 1.29065120788839 0.109844565289389 no 379 0.0984123253765134 561 1560000
SGTC_22 0964-0034 14.468 µM 1.28970512589822 0.110016699554747 no 380 0.0985765295930704 580 138402
SGTC_2731 amoxapine 43.43 µM 1.28907166096794 0.110132063040957 no 381 0.0986865873072841 413 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_755 1995-0008 37.3 µM 1.28612318507246 0.110670166785971 no 382 0.099200036875886 572 689533
SGTC_136 0097-0015 404.482 µM 1.28246418886761 0.111340558798076 no 383 0.0998399297765762 608 4861337
SGTC_2244 6635614 200 µM 1.27863952293914 0.112044406409923 no 384 0.100512012701045 413 836499
SGTC_2453 5731132 22.18 µM 1.27352708982639 0.112990199647902 no 385 0.101415532990154 601 1362040
SGTC_493 zm226600 134 µM 1.27349407957717 0.112996324958055 no 386 0.10142138605224 574 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1864 st057645 30.4 µM 1.2713346301456 0.113397542690259 no 387 0.101804813729593 516 688666
SGTC_120 rhodamine 6G 52.259 µM 1.26920735338466 0.113793775292894 no 388 0.10218355954599 672 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2283 7944793 200 µM 1.26873842795795 0.113881251243479 no 389 0.102267185934697 567 2970533
SGTC_980 1473-0395 201 µM 1.26831744308662 0.113959824907956 no 390 0.102342305181453 505 768876
SGTC_941 3237-0776 460 µM 1.26605249421284 0.114383223561137 no 391 0.102747144477822 539 760008
SGTC_1986 st071812 45 µM 1.26549833403755 0.114486985913344 no 392 0.102846372608058 518 11838594
SGTC_77 0828-0286 12.516 µM 1.26433053043576 0.114705867744809 no 393 0.103055707901336 581 745345
SGTC_2947 9072639 7.68 µM 1.26199673938215 0.115144182765663 no 394 0.103474979829918 612 16488146
SGTC_2710 st078562 53.7235 µM 1.25818047368534 0.115863488369942 no 395 0.104163247510263 556 17250908
SGTC_1499 4480-0877 67.3 µM 1.25532436676452 0.116403902834019 no 396 0.104680516537272 528 2861909
SGTC_455 paf C-16 10 µM 1.25500350216234 0.116464726344606 no 397 0.104738744310966 554 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1377 2944-0135 198 µM 1.25236988753934 0.116964809728496 no 398 0.105217556787153 591 1894137
SGTC_518 1021-0119 62.6 µM 1.25087046111198 0.117250206919561 no 399 0.105490871225631 570 1097762
SGTC_3067 9117431 49.47 µM 1.24856461007374 0.117690058953085 no 400 0.105912181574639 526 17150885
SGTC_380 3970-0968 6 µM 1.24506411749877 0.118360024579602 no 401 0.10655409130978 564 2891601
SGTC_2979 9012552 45.46 µM 1.23807234225332 0.11970625335875 no 402 0.107844619040536 525 17100905
SGTC_1685 st024049 53.0905 µM 1.23717317966945 0.119880162815555 no 403 0.108011398160712 553 1941139
SGTC_1425 4048-4433 7.33 µM 1.23451771363423 0.120394803193319 no 404 0.108505025119194 631 23734946
SGTC_1495 4469-0029 237 µM 1.23396724692537 0.120501680370679 no 405 0.108607554633678 721 793680
SGTC_472 calcifediol 10 µM 1.23090084125681 0.121098268426098 no 406 0.10917997647033 516 5283731 A vitamin D metabolite.
SGTC_1513 0337-0559 19 µM 1.22680806849077 0.121897775425592 no 407 0.109947368770745 542 775073
SGTC_1464 k208-0027 110 µM 1.22104618988748 0.123029608741133 no 408 0.111034265843991 625 X1464
SGTC_734 2023-0417 80 µM 1.22010440757937 0.123215305764437 no 409 0.111212648965876 599 3935732
SGTC_2912 7964298 10.93 µM 1.21852631521175 0.123526908107639 no 410 0.111512015466193 669 2975850
SGTC_1740 st038286 13.222 µM 1.21756658915959 0.123716680555922 no 411 0.111694358695603 612 716786
SGTC_3195 9113082 49.47 µM 1.21733556831354 0.123762392173475 no 412 0.111738283353794 569 17018038
SGTC_2655 perillic acid 100 µM 1.21727022237187 0.12377532418502 no 413 0.111750710007201 545 5702197 An apoptosis inducer.
SGTC_1266 0828-0227 32.9 µM 1.21459371409605 0.124305820273331 no 414 0.112260543748843 562 3913820
SGTC_2203 7227154 166.4 µM 1.21223860866243 0.124773926377697 no 415 0.112710528169401 568 896304
SGTC_2680 butyl paraben 22.24 µM 1.2110813017003 0.125004406175385 no 416 0.112932123430585 564 7184 An antifungal and steroid mimetic.
SGTC_376 3970-0862 59.1 µM 1.21101151148741 0.125018314525166 no 417 0.112945496441311 626 3135186
SGTC_1482 3346-2049 8.48 µM 1.20901699453756 0.125416254684288 no 418 0.11332815820179 587 3826804
SGTC_1125 tnp00248 1.32998 µM 1.20206519595446 0.12681016467468 no 419 0.114669134766953 757 24207736
SGTC_2263 7948595 193.29 µM 1.20194580443709 0.126834197792963 no 420 0.114692263160266 551 2971371
SGTC_3322 9139058 2.11 µM 1.20036415348481 0.127152878189875 no 421 0.114998972142744 644 4908926 YPR165W RHO1
SGTC_1578 josamycin 24.2 µM 1.19595743488351 0.128043706935023 no 422 0.115856585002299 562 5282165 A P450 substrate.
SGTC_1783 st039459 87.517 µM 1.19414645109908 0.128411055681213 no 423 0.116210342787371 695 729761
SGTC_790 1575-0012 79.1 µM 1.19348344313892 0.128545726214406 no 424 0.116340046330263 640 378741 YLR208W SEC13
SGTC_2467 5474540 200 µM 1.1907809534172 0.12909567129914 no 425 0.116869793975522 619 5413519
SGTC_347 4534-1311 26.2 µM 1.19014044903238 0.129226249972772 no 426 0.116995597215711 635 2862016
SGTC_544 k015-0020 52.4 µM 1.18799860708576 0.129663568936553 no 427 0.117416979236551 608 3008304
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 1.18799390132234 0.129664530881376 no 428 0.117417906221391 621 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2855 9016525 58.44 µM 1.1853556964644 0.130204606942621 no 429 0.117938420350428 640 43811474
SGTC_2305 7443522 69.23 µM 1.18469306315597 0.130340501125619 no 430 0.118069413082554 659 5415886
SGTC_2470 5664817 21.68 µM 1.18449322508164 0.130381503573043 no 431 0.118108938281606 633 2859561
SGTC_1767 st044992 70.3 µM 1.18440663945442 0.13039927183969 no 432 0.118126066622951 620 9600693
SGTC_3131 9127911 49.47 µM 1.18395907193889 0.13049114402947 no 433 0.118214632296545 614 45595681
SGTC_475 α-linolenic acid 10 µM 1.18316506819969 0.130654239315065 no 434 0.118371867070049 661 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2904 7225135 42.03 µM 1.18252147945587 0.130786541423387 no 435 0.11849942393873 654 4446116
SGTC_1165 k072-0275 30.3 µM 1.18247211714475 0.130796692622897 no 436 0.118509211372829 612 6153523 YGL055W OLE1
SGTC_1971 st069429 63.5 µM 1.18024334663315 0.131255599545879 no 437 0.118951721732408 606 1246522 YGL099W LSG1
SGTC_1305 1181-0477 144 µM 1.17680862267912 0.131964988981539 no 438 0.119635950110788 631 6252086
SGTC_2141 5621638 7.665 µM 1.17533604629189 0.132269935416192 no 439 0.119930149350379 623 2856238
SGTC_2224 6650123 117.647 µM 1.17431254473275 0.132482171735327 no 440 0.120134930193465 600 2908370
SGTC_1229 0139-0193 12.2 µM 1.17428370702323 0.132488155005296 no 441 0.120140703571237 686 3090752
SGTC_213 1246-0773 967 nM 1.17105183629884 0.133159885984572 no 442 0.120788970928037 668 6251622
SGTC_1385 3091-4834 14.1 µM 1.16836588470357 0.133719930442155 no 443 0.121329604927587 589 4072814
SGTC_2558 carylophyllene oxide 100 µM 1.16656033585755 0.134097312101926 no 444 0.121693984590314 694 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_3185 9108267 49.47 µM 1.16586609822196 0.134242610777118 no 445 0.12183429387419 642 4910486
SGTC_2379 9035213 200 µM 1.1635483383895 0.134728483273161 no 446 0.122303548955102 701 646551
SGTC_635 k038-0028 24.7 µM 1.16192445878992 0.135069615566138 no 447 0.122633075502339 658 4035102
SGTC_1980 st071811 45.7 µM 1.16144475344253 0.135170501659015 no 448 0.1227305390038 633 4974850
SGTC_2865 9030313 51.95 µM 1.16090874520118 0.13528328983063 no 449 0.122839506025799 598 42562754
SGTC_2364 9055074 200 µM 1.16030245750582 0.1354109441146 no 450 0.122962842157897 607 6470630
SGTC_1151 3909-8316 15.3 µM 1.15881058839572 0.135725409570401 no 451 0.123266700278187 658 800431
SGTC_821 1114-0266 29.2 µM 1.15763969374161 0.135972568122444 no 452 0.123505551808023 642 3123235
SGTC_697 0508-1955 564 µM 1.1570932684045 0.136088015822491 no 453 0.123617128320198 709 6243113
SGTC_2319 6033012 152.6 µM 1.15667084129899 0.136177311383934 no 454 0.123703433561132 588 847246
SGTC_404 fumagillin 50 µM 1.15172861126128 0.137225013256713 no 455 0.124716305657188 676 12015870 A methionine aminopeptidase binder.
SGTC_329 k048-0121 21.3 µM 1.14927111349378 0.137748021714738 no 456 0.125222102718962 637 6832902
SGTC_3347 9188721 44.724 µM 1.14816862480456 0.13798309647939 no 457 0.125449479430035 625 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_3079 9117512 49.47 µM 1.14667413731256 0.13830219061804 no 458 0.125758161607518 697 7185044
SGTC_2395 5646831 180.19 µM 1.14636288317399 0.138368711003281 no 459 0.125822516880003 674 6808628
SGTC_2177 5811945 192 µM 1.14503302660495 0.138653169928898 no 460 0.126097738306375 653 5343475
SGTC_642 0335-0876 158 µM 1.14422298559549 0.138826634387963 no 461 0.126265586458529 672 6812350
SGTC_3240 9133527 49.47 µM 1.14326586137959 0.139031786061752 no 462 0.126464112246448 659 17617455
SGTC_2658 polymyxin b sulfate 77.05 µM 1.14257849944776 0.139179243679795 no 463 0.126606818293637 693 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_983 1491-0821 12.2 µM 1.13988269568624 0.139758593137346 no 464 0.127167587599012 661 46495113
SGTC_102 gallobenzophenone 83.616 µM 1.13877681609939 0.139996728920978 no 465 0.127398126966408 679 70837
SGTC_615 k087-0205 167 µM 1.13847269219925 0.14006226608263 no 466 0.127461577682956 640 9642773
SGTC_13 0199-0087 65 µM 1.13777893603665 0.140211845027147 no 467 0.127606401338898 683 4589825
SGTC_2498 4'-Methoxychalcone 54.63 µM 1.13767395132294 0.140234489954363 no 468 0.12762832717106 634 641818 YHR062C RPP1
SGTC_2938 9059746 27.26 µM 1.13680579249042 0.140421844740003 no 469 0.127809740660446 638 6471769
SGTC_1988 st071872 53.4 µM 1.13505854723391 0.140799427588405 no 470 0.128175394189815 680 16414116
SGTC_2635 hydroquinidine 100 µM 1.13191459606489 0.141480574694791 no 471 0.128835170795823 686 442912 An experimental heart treatment.
SGTC_237 nikkomycin 200 µM 1.13062945015751 0.141759647552366 no 472 0.12910554334735 702 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_3348 9149464 3.537 µM 1.1298008594388 0.141939775784802 no 473 0.129280072999763 691 1951442
SGTC_1049 3226-0134 66 µM 1.12959210165996 0.141985182292777 no 474 0.129324070333058 727 5702385
SGTC_116 0155-0182 31.788 µM 1.12632773915622 0.142696486765905 no 475 0.130013410298377 802 771486
SGTC_2482 5981709 142.65 µM 1.12482870362461 0.143023932374213 no 476 0.130330814335358 705 877755
SGTC_1046 2001-0062 216 µM 1.12477924425581 0.143034744801051 no 477 0.130341295931565 669 739778
SGTC_984 1492-0255 2.91 µM 1.12363249039724 0.143285594165697 no 478 0.130584483386016 652 1585198
SGTC_3115 9123671 49.47 µM 1.12341037189916 0.143334216323723 no 479 0.13063162340399 708 3286988
SGTC_3110 9122132 49.47 µM 1.12130052927756 0.143796620379337 no 480 0.131079980172154 700 918317
SGTC_1655 st012546 55.1 µM 1.11987837289794 0.144108874791353 no 481 0.131382797790709 648 720985 YLR208W SEC13
SGTC_180 1486-1293 102.781 µM 1.11685253900648 0.144774759398322 no 482 0.132028690183312 706 4140536
SGTC_525 k781-2675 26.7 µM 1.11650751908104 0.14485081811187 no 483 0.132102476735449 710 3651118 YDL195W SEC31
SGTC_1699 st031318 29.054 µM 1.11613345805242 0.14493330925129 no 484 0.132182506187205 689 5340658
SGTC_1642 st009582 77.7 µM 1.11391176048231 0.145423908713195 no 485 0.132658521803537 650 6739311
SGTC_3015 9080845 49.47 µM 1.11382143451973 0.145443878264984 no 486 0.132677899776412 736 5296973
SGTC_2511 berberine 10.47 µM 1.11216544602045 0.14581031635649 no 487 0.133033510864703 691 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_507 nimesulide 162 µM 1.11054062185063 0.14617046100166 no 488 0.133383066800953 713 4495 A COX2 inhibitor.
SGTC_892 0929-0076 29 µM 1.10575069382753 0.147235629910546 no 489 0.134417220768791 734 5751038
SGTC_1212 0520-0165 585 µM 1.10507844468537 0.147385537831016 no 490 0.134562799901342 686 5403258
SGTC_2957 9076800 11.52 µM 1.10458428650632 0.147495797632946 no 491 0.134669881480099 628 16459615
SGTC_377 3970-0964 33.1 µM 1.10413256865245 0.147596636208116 no 492 0.134767817603901 787 16481235
SGTC_197 4544-0043 41.561 µM 1.10317096229619 0.147811452754195 no 493 0.134976464439181 723 896523
SGTC_1936 st074407 74.3 µM 1.1009328426527 0.148312244266823 no 494 0.135462943403142 739 809813
SGTC_76 0433-0009 400.328 µM 1.09900442837106 0.148744646747096 no 495 0.135883067160489 625 2841569
SGTC_3234 9132280 49.47 µM 1.09895109423975 0.148756617659499 no 496 0.135894699183458 719 17612295
SGTC_1174 0739-0097 51.1 µM 1.09610716261372 0.149395874306475 no 497 0.136515940245976 712 728447
SGTC_653 0203-0016 55.2 µM 1.0956735159499 0.149493509943658 no 498 0.136610838348822 716 295302
SGTC_1291 0993-0025 5.79 µM 1.09560162510652 0.149509700296508 no 499 0.136626575111206 732 4353356
SGTC_2621 lithochol-11-enic acid 100 µM 1.09554160135419 0.149523218988554 no 500 0.136639715140508 761 6708711
SGTC_1865 st057639 52.2 µM 1.09538569456448 0.149558336497242 no 501 0.136673849329502 701 688818
SGTC_1828 st055811 49 µM 1.09508116281107 0.149626947180918 no 502 0.136740540241925 672 5877589
SGTC_2911 7942208 15.64 µM 1.09305628216842 0.150083684690301 no 503 0.137184544588332 674 1243384
SGTC_37 0566-0070 1.56 µM 1.08942893806359 0.150904199760523 no 504 0.137982388008004 770 1626686
SGTC_1960 st011366 51.8 µM 1.08812601393773 0.151199652234567 no 505 0.138269740491844 697 3972846
SGTC_3277 9138724 49.47 µM 1.08553258163833 0.151788886308738 no 506 0.138842920630725 619 15943418
SGTC_1156 4092-0367 4.88 µM 1.0850782861914 0.151892260172606 no 507 0.138943491764555 721 1357585
SGTC_975 1335-0046 28.5 µM 1.08394425536693 0.152150510282996 no 508 0.139194757929149 704 16486740
SGTC_3335 9143315 29.6265 µM 1.08394291814469 0.152150814977402 no 509 0.139195054398667 696 4899691
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.08366990267109 0.152213031737235 no 510 0.139255592429306 649 4620898
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.08335987517801 0.152283703545442 no 511 0.139324359168846 710 6312947
SGTC_2569 tetrandrine 100 µM 1.08158777439061 0.152688077916218 no 512 0.13971786965106 642 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1790 st045711 43.5 µM 1.07963760429704 0.153133908290831 no 513 0.140151794550522 712 585119
SGTC_195 4234-0266 16.654 µM 1.07878210174834 0.153329757586061 no 514 0.140342437745317 774 2303354
SGTC_2087 5276107 200 µM 1.07838325346301 0.153421122196453 no 515 0.140431378660861 725 144405
SGTC_914 3820-6779 408 µM 1.07620897920527 0.153919819583774 no 516 0.14091690243288 700 2893481
SGTC_1949 st076024 69.1 µM 1.07365977272081 0.154505877091227 no 517 0.141487598599043 693 2921930
SGTC_1964 st076914 61 µM 1.07190451779753 0.154910263056943 no 518 0.141881460404953 746 24208661
SGTC_3047 9092122 49.47 µM 1.07175828345009 0.15494398490474 no 519 0.141914307412477 697 17173831
SGTC_2194 5927483 104.545 µM 1.07149809797964 0.155003996029134 no 520 0.141972762732506 762 760979
SGTC_1265 0819-1001 68.8 µM 1.07082088803304 0.155160264756827 no 521 0.142124986482494 694 3106768
SGTC_1389 3405-0187 19 µM 1.07036773037638 0.155264890643791 no 522 0.142226909263078 665 799890
SGTC_2715 st079500 56.4 µM 1.06856484540705 0.155681605156214 no 523 0.142632898170404 682 28246688
SGTC_825 1988-2224 89.6 µM 1.06754846555068 0.15591685358367 no 524 0.142862120268872 745 1180859
SGTC_1361 1608-0041 5.61 µM 1.06624619929877 0.156218614769759 no 525 0.143156181440957 743 X1361
SGTC_3121 9125696 49.47 µM 1.06577028996911 0.156328988432583 no 526 0.143263747163307 729 1235365
SGTC_3091 9116372 49.47 µM 1.0638459229023 0.156775814404121 no 527 0.143699251925777 685 17169793
SGTC_112 phenothiazine 287.218 µM 1.06329919460907 0.156902914450381 no 528 0.143823145153989 770 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_3292 9120825 59.784 µM 1.06260331010037 0.157064787453698 no 529 0.143980942643309 761 24824900
SGTC_89 0302-0250 142.109 µM 1.06215842774368 0.157168331190183 no 530 0.144081884511913 791 4203518 YLR208W SEC13
SGTC_3132 9126706 49.47 µM 1.0585337696008 0.158013621265787 no 531 0.144906081749939 712 850858
SGTC_901 1112-0062 60.1 µM 1.05792373981192 0.15815617642426 no 532 0.145045105559491 722 1908457
SGTC_189 3970-0742 2.116 µM 1.05749803018667 0.158255708610612 no 533 0.145142176571436 739 2891807
SGTC_664 1222-0054 14.9 µM 1.05491012226805 0.158861653457142 no 534 0.145733216188189 763 6813991
SGTC_2134 5324836 1.464 µM 1.05460763182574 0.158932579109142 no 535 0.145802405957139 670 699272
SGTC_2940 9060638 45.86 µM 1.05298048043361 0.159314457139203 no 536 0.146174969152488 747 4027022
SGTC_909 3448-9333 149 µM 1.05263671977016 0.159395211539026 no 537 0.146253760576811 708 3344074
SGTC_60 0986-0278 202 µM 1.05193945615065 0.159559091241087 no 538 0.146413663982491 601 3110598
SGTC_3249 9135183 49.47 µM 1.05091793681976 0.159799380675865 no 539 0.146648140784486 782 4902779
SGTC_126 0417-1624 672.48 µM 1.04873360722278 0.160313988971486 no 540 0.147150371020057 894 41912 YDL195W SEC31
SGTC_811 0416-0114 265 µM 1.048557913509 0.160355427830069 no 541 0.14719081730184 730 6612453
SGTC_451 chloral hydrate 100 µM 1.04771607649453 0.160554079371629 no 542 0.147384719193013 810 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_289 k017-0060 526 µM 1.04684312891639 0.160760241898262 no 543 0.147585967538049 721 5512909
SGTC_1375 2910-0797 186 µM 1.04668969497315 0.160796495981945 no 544 0.147621359036817 737 742508
SGTC_952 1185-0122 232 µM 1.04590905019732 0.160981033015527 no 545 0.147801512758279 737 678600
SGTC_2106 5357045 167.29 µM 1.04589938270575 0.160983319185157 no 546 0.147803744701318 771 668842
SGTC_260 nsc-65238 3.989 µM 1.04425090280844 0.161373461794376 no 547 0.148184660868828 734 3246252
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.04200659090947 0.161905609233751 no 548 0.148704311614727 766 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2431 5490079 200 µM 1.0384313470458 0.162755691644894 no 549 0.149534640961314 777 5722345
SGTC_431 k089-0097 107 µM 1.03673359175293 0.16316038005086 no 550 0.149930016097929 815 5499420
SGTC_1692 fluoroquinolonic acid 71 µM 1.03449689892697 0.163694530625374 no 551 0.150451962889384 745 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1545 lovastatin 49.4 µM 1.03255305693154 0.164159665653156 no 552 0.150906553038196 806 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1248 0469-0687 58.6 µM 1.03254578915882 0.164161406339534 no 553 0.150908254405442 780 4017482
SGTC_2289 7946404 165.07 µM 1.03186012387741 0.164325682185053 no 554 0.151068824340005 816 1246120 YPR165W RHO1
SGTC_480 am 92016 50 µM 1.03147111749702 0.164418930064445 no 555 0.151159972857474 706 2129 K+ channel blocker.
SGTC_2256 7954252 200 µM 1.02972126793955 0.16483880680874 no 556 0.151570434430591 671 2972920
SGTC_1486 3970-0793 4.53 µM 1.02681824960667 0.16553691703054 no 557 0.152253027182242 781 2844330
SGTC_2118 5526350 200 µM 1.02623260452423 0.165677982888769 no 558 0.152390978132088 800 743594
SGTC_797 k781-0471 270 µM 1.02364399866572 0.166302437928728 no 559 0.153001727668481 797 23738129
SGTC_2564 betulinic acid 100 µM 1.02152599939371 0.166814496622951 no 560 0.153502648775497 841 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1518 st038567 90.8 µM 1.02138841248106 0.166847795509421 no 561 0.153535226536068 771 77966
SGTC_921 1561-0023 372 µM 1.0200871909611 0.167162930126223 no 562 0.153843555529327 811 24050882
SGTC_685 1278-0033 54.9 µM 1.01964516237925 0.167270069495346 no 563 0.153948388937646 804 3590572
SGTC_1144 3486-0183 12.5 µM 1.01925051044915 0.167365763050363 no 564 0.154042026228275 816 6744069
SGTC_287 k060-0039 29.6 µM 1.01910067399562 0.167402104007144 no 565 0.154077587117348 771 5861974
SGTC_2070 5230947 200 µM 1.01574206691059 0.168218026290321 no 566 0.154876115067022 833 2835538
SGTC_2927 9011802 47.9 µM 1.01464580767263 0.168484898609242 no 567 0.1551373476345 743 43912568
SGTC_2388 9080168 200 µM 1.01429995216236 0.168569149808022 no 568 0.155219823436594 733 15943073
SGTC_1852 st056254 31.4 µM 1.01036450480667 0.169529740803108 no 569 0.156160343567619 765 442583
SGTC_999 SEC7.066 22.7 µM 1.00934275480167 0.169779709730603 no 570 0.156405141087205 842 740511 YDR170C SEC7
SGTC_1816 st051957 91.6 µM 1.00539819557549 0.170746953891595 no 571 0.157352574195676 795 674121
SGTC_2990 9074105 71.4286 µM 1.00337492511479 0.171244445164486 no 572 0.157839998891356 767 6502001
SGTC_2186 6124449 200 µM 1.00305806916435 0.171322439049928 no 573 0.157916422147706 798 3834182 YLR033W RSC58
SGTC_301 4119-0100 24.5 µM 1.00101188090034 0.171826653673753 no 574 0.158410532254124 823 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2755 lomerizine 42.69 µM 0.997664505896748 0.172653543208351 no 575 0.159221035049746 813 3949 A calcium channel blocker.
SGTC_2851 9015922 71.43 µM 0.997662917653127 0.172653936147413 no 576 0.15922142025606 795 2996893
SGTC_656 4090-1979 187 µM 0.995622449014264 0.173159228692761 no 577 0.15971681154445 861 22330961
SGTC_1029 k015-0030 64.7 µM 0.991962914806468 0.174067816046099 no 578 0.160607808192315 784 2208316
SGTC_1330 1469-0054 61.8 µM 0.989002502918648 0.174805038991146 no 579 0.161330958540156 877 7102664
SGTC_1026 k007-1105 30.6 µM 0.98808324919775 0.17503436078439 no 580 0.161555939353607 860 7066794
SGTC_3302 9125395 16.351 µM 0.987467151118586 0.175188162578552 no 581 0.161706839406104 792 17599668
SGTC_1098 clofazimine 15.1 µM 0.986116025952314 0.17552575542004 no 582 0.162038090150985 849 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_3108 9121785 49.47 µM 0.98270226134474 0.176380555897193 no 583 0.162876998718454 809 17140271
SGTC_129 0088-0017 176.636 µM 0.981930916152019 0.17657406350706 no 584 0.163066941812031 792 182446
SGTC_1386 3228-0095 33.8 µM 0.981715411473148 0.176628151219758 no 585 0.163120035376541 784 870181
SGTC_2446 5162541 200 µM 0.980250165243614 0.176996178816311 no 586 0.16348132373992 776 1549321
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.978421390712055 0.177456193472583 no 587 0.163932976450332 808 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_629 3448-6466 76.7 µM 0.978406386805823 0.177459970712514 no 588 0.163936685312665 839 573744
SGTC_338 4055-0136 114 µM 0.97822580840815 0.177505435383999 no 589 0.163981327320387 811 2900563
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.977766707478858 0.177621057468243 no 590 0.164094860281558 748 521171
SGTC_1358 1509-0022 2.48 µM 0.976928757616358 0.177832213108688 no 591 0.164302211785343 845 3258434
SGTC_996 3970-0799 1.8 µM 0.976357609510007 0.17797622786875 no 592 0.164443640254203 1012 6615648 YGL040C HEM2
SGTC_2787 5284540 71.43 µM 0.975790321553173 0.178119342071297 no 593 0.164584190958487 828 736958
SGTC_808 0711-0032 135 µM 0.975258065901725 0.178253684342951 no 594 0.164716132856841 846 4252555
SGTC_2571 chrysanthemic acid 100 µM 0.974948121972622 0.178331944152371 no 595 0.164792997027902 769 2743 An insecticide.
SGTC_2222 6885208 172.143 µM 0.97413105789496 0.178538353853224 no 596 0.164995735185305 806 609514
SGTC_1985 st071382 65.5 µM 0.973938713377668 0.178586966497487 no 597 0.165043485115855 839 6123237
SGTC_1280 0880-0253 10.1 µM 0.973715029235828 0.178643510318326 no 598 0.165099026425107 830 6836607
SGTC_2727 riluzole 51.77 µM 0.972976694088511 0.178830229798367 no 599 0.1652824426885 774 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2537 larixol 68.93 µM 0.972972712429208 0.178831237063366 no 600 0.165283432164492 880 6708759
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.972082794784442 0.179056454630542 no 601 0.165504680392248 812 5379071
SGTC_80 0159-0065 512.242 µM 0.971479172673841 0.179209318947815 no 602 0.165654859807831 749 1548079
SGTC_3070 9117005 49.47 µM 0.969896045523882 0.179610627873173 no 603 0.166049155699819 786 8779016
SGTC_1611 st001856 99.4 µM 0.969075019326672 0.179818973066578 no 604 0.166253880243079 805 647478
SGTC_1431 4049-0260 9.09 µM 0.967388751207092 0.180247359584202 no 605 0.16667486562909 853 3854841
SGTC_1658 st012944 20 µM 0.962822969714311 0.181410481085515 no 606 0.167818185774672 807 24207260
SGTC_2458 5808907 16.39 µM 0.962792140240528 0.181418350754734 no 607 0.167825922925009 907 2731747
SGTC_2818 7996756 12.99 µM 0.962108940545896 0.181592802206118 no 608 0.167997441769248 773 2241621
SGTC_787 4152-0075 138 µM 0.959949341251947 0.182144934640806 no 609 0.168540355764095 825 9566539
SGTC_1981 st071826 47 µM 0.958291135739767 0.18256959000684 no 610 0.16895798620197 792 11838600
SGTC_278 4092-0821 23.9 µM 0.950727500900864 0.18451441897218 no 611 0.170871361987383 869 877900
SGTC_1644 st010134 20.9 µM 0.950558906258726 0.184557915820071 no 612 0.170914168809406 822 3818134
SGTC_1694 st024011 44.9 µM 0.948432080286186 0.185107177234876 no 613 0.171454767167123 904 2787533
SGTC_1838 st055369 84.5 µM 0.945643399138342 0.18582890217428 no 614 0.172165250329761 844 676036
SGTC_599 1935-0052 86.5 µM 0.945011143876197 0.185992775450564 no 615 0.172326593380534 879 9557311
SGTC_1975 st070967 30.8 µM 0.944178848389503 0.18620863340304 no 616 0.17253913102867 930 261391
SGTC_667 1498-1044 59 µM 0.943891516926809 0.186283189584416 no 617 0.172612543712506 888 6739982
SGTC_317 4495-0002 170 µM 0.940360561020879 0.187200904486019 no 618 0.173516322458021 814 15991618
SGTC_1118 chelidonine 707.474 nM 0.940194700365837 0.187244081222082 no 619 0.173558849853325 922 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1539 benzyladenosine 56 µM 0.939987893360705 0.187297925709727 no 620 0.173611885361743 844 92208 A nucleotide analog.
SGTC_1073 triclabendazole 3.09 µM 0.937790740089629 0.187870569795325 no 621 0.174175980375934 922 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1731 st035964 63 µM 0.937443200938907 0.187961247857329 no 622 0.17426531382587 828 6739575
SGTC_1617 st002906 78 µM 0.937205803352645 0.188023203899726 no 623 0.174326352591844 886 5150859
SGTC_3236 9132701 49.47 µM 0.936753109717129 0.188141382858743 no 624 0.174442785103978 857 24282524
SGTC_3029 9088683 49.47 µM 0.936742559030684 0.18814413773855 no 625 0.174445499322672 863 25236615
SGTC_583 1488-1091 88.9 µM 0.934568169460752 0.188712421699353 no 626 0.175005444683247 1028 4303273
SGTC_2582 agaric acid 100 µM 0.933917108495096 0.188882784264565 no 627 0.175173326472673 996 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1405 3909-7894 12 µM 0.933882424620123 0.188891862622263 no 628 0.175182272879328 874 7104060
SGTC_1806 st050005 60.3 µM 0.929413345592147 0.190063873444629 no 629 0.176337457088127 857 5194765
SGTC_91 0417-1751 58.384 µM 0.92761851220944 0.190535821586413 no 630 0.176802745757251 996 6795624
SGTC_741 4582-0002 126 µM 0.92691767349987 0.190720300992391 no 631 0.176984640135672 864 2912688
SGTC_1565 sinapyl alcohol 95.1 µM 0.926454656128244 0.190842239602688 no 632 0.177104875647095 846 5280507 A phenol propionate derived from cinnamic acid.
SGTC_3140 9094243 49.47 µM 0.924949657434239 0.191238921026769 no 633 0.177496047318594 958 19291112
SGTC_2610 ononetin 44.17 µM 0.924465492612109 0.191366642600394 no 634 0.17762200485104 872 259632
SGTC_2844 9010103 25.97 µM 0.923790636260335 0.19154475535455 no 635 0.177797665671696 835 2480525
SGTC_1185 1319-0113 81.3 µM 0.923316291234578 0.191670008530184 no 636 0.177921200227939 848 4672763
SGTC_2733 amorolfine 100 µM 0.921520489358866 0.192144653253439 no 637 0.178389374466834 845 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2216 7189485 200 µM 0.921497552122212 0.19215072039502 no 638 0.178395359331185 922 731273
SGTC_851 0394-0702 453 µM 0.921325418935047 0.192196255182847 no 639 0.178440276963741 935 762646
SGTC_336 4111-0029 111 µM 0.918883710774828 0.192842876569925 no 640 0.179078200458876 822 3131175
SGTC_219 mitoxanthrone 164.414 µM 0.91770742570774 0.193154858099135 no 641 0.179386029505516 836 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2353 9059630 146.67 µM 0.915831360821647 0.193653076653879 no 642 0.179877676073023 928 4779114
SGTC_2949 9072542 2.23 µM 0.915299565150814 0.193794445786545 no 643 0.180017193671124 888 16457352
SGTC_1157 4092-0394 27.6 µM 0.913939897099689 0.194156177119648 no 644 0.180374213990366 961 3659885
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.912781914738169 0.194464575270934 no 645 0.180678625918661 863 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1837 st055472 66.5 µM 0.911883899163976 0.194703943262466 no 646 0.180914919071204 911 676091
SGTC_2240 6690706 185.951 µM 0.911708690369674 0.194750666434945 no 647 0.180961044001817 776 805876
SGTC_3263 9137018 49.47 µM 0.911467151264048 0.194815089184981 no 648 0.181024642927965 850 43844957
SGTC_156 3474-0145 5.642 µM 0.910762995182822 0.195002974023182 no 649 0.18121013203587 894 2265471
SGTC_3330 9141424 71.43 µM 0.910171288250646 0.195160940024167 no 650 0.181366091748501 947 27261020
SGTC_1501 4491-0275 38.4 µM 0.905469326303871 0.196418969394608 no 651 0.182608401446556 934 5104718
SGTC_715 0868-0130 184 µM 0.905390338809581 0.196440144714565 no 652 0.182629316087047 905 2876258
SGTC_2437 5741531 144.16 µM 0.90513854638507 0.196507655585357 no 653 0.182695996726427 940 2262990
SGTC_2302 7771753 200 µM 0.904014645061028 0.196809168677538 no 654 0.182993817920064 914 2203047
SGTC_293 4049-0273 38.5 µM 0.903868157268626 0.196848488115824 no 655 0.18303265783817 850 1380311
SGTC_290 2043-6722 48.1 µM 0.903667544036604 0.196902343320077 no 656 0.18308585697324 906 773758 YLR208W SEC13
SGTC_1876 myriocin 605 nM 0.903036214601531 0.197071883737761 no 657 0.183253337479711 931 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2241 6772625 37.8075 µM 0.902941619016082 0.197097294525708 no 658 0.183278440239311 875 2285411
SGTC_1 0258-0098 57.368 µM 0.901062531238992 0.197602476249627 no 659 0.183777536647921 793 6790032 YDR047W HEM12
SGTC_2913 7966556 36.57 µM 0.899140939127623 0.198119893647315 no 660 0.184288797133496 890 2976516
SGTC_932 2857-0803 154 µM 0.897565080379176 0.198544827058232 no 661 0.184708731328963 971 674898
SGTC_828 2074-0507 139 µM 0.894527739174767 0.19936540152083 no 662 0.185519797477288 932 X828
SGTC_687 k029-0044 34.9 µM 0.893994410345479 0.199509697219019 no 663 0.185662440933553 970 5829338
SGTC_1051 3253-3903 78 µM 0.893745513636404 0.199577059404138 no 664 0.185729033815836 968 5509239
SGTC_1286 0929-0070 131 µM 0.893566964881326 0.199625390828897 no 665 0.185776814068558 941 1420408
SGTC_151 3013-0144 2.285 µM 0.89110504907086 0.200292525504993 no 666 0.186436408238088 915 906558 YHR107C CDC12
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.890544601826357 0.200444583554781 no 667 0.186586765189788 900 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_382 3229-0966 23.2 µM 0.889837385958205 0.200636561133821 no 668 0.186776604391818 956 5722370
SGTC_1874 staurosporine 7.6 µM 0.888638638242034 0.200962219724487 no 669 0.187098659300288 953 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_215 1287-0124 461.5 µM 0.888442397799811 0.201015561703864 no 670 0.187151413848665 919 5560863
SGTC_459 nigericin 15.3 µM 0.887715603303911 0.20121319258735 no 671 0.187346875278471 992 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2136 5328288 199.296 µM 0.887584926251363 0.201248738810402 no 672 0.187382032463298 813 262395
SGTC_1221 2958-7315 257 µM 0.887216923171753 0.201348861690877 no 673 0.18748106144697 883 4562705
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.886089132516174 0.20165588647038 no 674 0.187784749333629 994 66535 A nucleotide analog.
SGTC_723 4182-0001 115 µM 0.885732017617353 0.201753164290719 no 675 0.187880975398692 882 744821 YLR208W SEC13
SGTC_1092 toremifene 6.32 µM 0.885115852761702 0.20192107317732 no 676 0.188047075103831 1012 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_351 caspofungin 25 nM 0.884058378259143 0.202209436689943 no 677 0.188332349945917 1031 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1236 0330-0013 258 µM 0.883768610957579 0.202288496534735 no 678 0.188410567032762 906 4617066
SGTC_303 1348-1668 34.2 µM 0.883672179711995 0.202314810847048 no 679 0.188436601227901 918 5380509
SGTC_474 dl-dihydrosphingosine 5 µM 0.883196597378482 0.202444618458011 no 680 0.188565029855623 945 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2404 5161160 200 µM 0.880318444860762 0.203231256581706 no 681 0.189343411622972 955 2831543
SGTC_2442 5158906 48.48 µM 0.879527863392902 0.203447652190543 no 682 0.18955756613907 943 1893835
SGTC_194 1486-1323 56.904 µM 0.879389617079828 0.20348550667517 no 683 0.189595029919095 936 5178754
SGTC_684 1140-0066 328 µM 0.878727291056175 0.203666922482266 no 684 0.189774578801706 960 6813534
SGTC_251 melphalan 456.522 µM 0.876404656411919 0.204303870278509 no 685 0.190405043925582 1030 460612 A DNA alkylator.
SGTC_3094 9117742 49.47 µM 0.875957773535951 0.204426557130541 no 686 0.190526494968419 996 17149698
SGTC_2414 st077232 92.9 µM 0.875471523443789 0.204560101631402 no 687 0.190658699007027 860 729801
SGTC_1683 st010134 710 nM 0.87435431595396 0.204867129867675 no 688 0.190962664043815 925 3818134
SGTC_361 000s-0510 1.45 µM 0.873517052833188 0.20509740400149 no 689 0.191190657756467 924 660
SGTC_2427 5545055 42.75 µM 0.872167083074301 0.205469012655489 no 690 0.191558617036983 990 5372858
SGTC_718 1130-0073 349 µM 0.86997931813385 0.206072091009783 no 691 0.192155853359283 954 6740020
SGTC_2171 5739187 198.077 µM 0.869657525782656 0.206160884618004 no 692 0.192243795216935 915 2262761
SGTC_2908 7930301 100 µM 0.869602763800866 0.206175997595714 no 693 0.192258763438069 978 2223178
SGTC_2723 salbutamol 83.58 µM 0.869495235356061 0.206205674747327 no 694 0.192288156514491 877 9884233 β2-adrenoceptor agonist
SGTC_429 1112-0049 25.5 µM 0.865390846111497 0.207340351477618 no 695 0.193412151766329 878 2836170
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.861384620252625 0.208451442798069 no 696 0.194513121891888 1107 688664
SGTC_570 0987-0065 62.6 µM 0.860714098765882 0.208637748431097 no 697 0.194697763041632 858 3104428
SGTC_3286 9117135 37.221 µM 0.860674754819313 0.208648683267106 no 698 0.194708600474483 920 3438150
SGTC_1963 st076565 50.3 µM 0.859419011402417 0.208997868597898 no 699 0.195054692313099 952 4914280
SGTC_582 0987-0078 156 µM 0.859240239477736 0.209047607787822 no 700 0.195103993521577 1082 1625765
SGTC_2996 9066192 71.4286 µM 0.858730731024199 0.209189405076469 no 701 0.195244545851778 939 6472854
SGTC_836 0330-0104 1.35 µM 0.858669042746052 0.209206576897785 no 702 0.19526156727347 957 46494820
SGTC_2279 7948423 32.93 µM 0.855899024033975 0.209978506402597 no 703 0.196026817427817 951 1247112
SGTC_10 0279-0212 42.575 µM 0.855259314181597 0.210157013894448 no 704 0.196203803018877 1050 39851 YBR002C RER2
SGTC_706 4262-0057 46.9 µM 0.8549864934842 0.210233170105108 no 705 0.196279312533435 971 883298
SGTC_509 pifithrin 175 µM 0.854791263828595 0.210287677203624 no 706 0.19633335772382 1026 4817 A p53 inhibitor.
SGTC_1898 st060199 18.6 µM 0.85243668579012 0.21094571638208 no 707 0.196985882956125 976 688866
SGTC_931 2812-0076 566 µM 0.852081244783804 0.211045157048445 no 708 0.197084500392276 986 3450959
SGTC_3298 9116858 71.43 µM 0.850711281038251 0.211428684665021 no 709 0.197464877520171 987 2506942
SGTC_324 1315-0088 19.6 µM 0.850033286244083 0.211618643299827 no 710 0.197653290180822 929 6787421
SGTC_3254 9136651 49.47 µM 0.848934132407946 0.211926813244281 no 711 0.197958972408116 1009 16454030
SGTC_3198 9112019 49.47 µM 0.8459172473701 0.21277400569607 no 712 0.198799455086222 975 45595555
SGTC_1721 st082152 9.2685 µM 0.84497436734523 0.21303918735536 no 713 0.199062575348086 952 5296051
SGTC_3243 9134147 49.47 µM 0.841366969150556 0.21405553372792 no 714 0.200071191972276 1049 24282180
SGTC_1561 5-methoxyflavone 52.9 µM 0.840721542303046 0.214237673092773 no 715 0.200251974647171 958 94525
SGTC_2694 st077685 81.9 µM 0.84042316153991 0.214321906568421 no 716 0.200335583626774 960 2838096
SGTC_228 caffeine 993.056 µM 0.838674258489736 0.214816012535405 no 717 0.20082606360195 946 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1308 1187-1617 41.4 µM 0.836034750619047 0.21556298689559 no 718 0.201567676838731 1012 2882570
SGTC_1570 verbenone 133 µM 0.835864378381825 0.215611253524102 no 719 0.201615602031118 1003 29025 A natural terpanoid with antifungal properties.
SGTC_2600 tangeritin 87.95 µM 0.827285401331125 0.218049777571153 no 720 0.204037658121591 951 68077 A bioactive flavone.
SGTC_1798 st045719 60.953 µM 0.825898728154077 0.218445418523262 no 721 0.204430771073586 969 3980186
SGTC_3188 9110789 49.47 µM 0.823668905316658 0.219082490263297 no 722 0.205063856042088 1006 849217
SGTC_2719 novobiocin 32.65 µM 0.821885155133545 0.219592885039702 no 723 0.205571131250999 975 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2484 5809818 12.04 µM 0.820800741052774 0.219903508209748 no 724 0.205879888212188 965 2870548
SGTC_191 3914-0123 66.505 µM 0.820476697296174 0.219996377288765 no 725 0.205972204082513 886 3144412
SGTC_1141 3253-0389 52.6 µM 0.820437555370389 0.22000759666286 no 726 0.205983356772039 1016 5402031
SGTC_1922 5578187 25 µM 0.820000331536927 0.220132941825613 no 727 0.206107959085747 992 1350412
SGTC_127 0180-0333 59.125 µM 0.814468695835477 0.221722307663359 no 728 0.207688249247481 1047 771601
SGTC_3102 9121669 49.47 µM 0.81370969337998 0.221940896837448 no 729 0.207905639875175 1023 41905072
SGTC_441 propafenone 146 µM 0.813601547241688 0.221972052434757 no 730 0.207936625617609 1034 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_181 1447-1644 8.07 µM 0.811406024015803 0.222605095915386 no 731 0.208566270427465 1018 534600
SGTC_1322 1348-1070 12 µM 0.809090503352346 0.223273852479325 no 732 0.209231545178985 1021 6758089
SGTC_1419 3993-2473 62.6 µM 0.808992868861566 0.223302075863929 no 733 0.209259624069361 1039 704026
SGTC_1011 4112-3381 17.4 µM 0.808757013570064 0.223370263369606 no 734 0.209327463294945 1009 2877139
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.808559704179051 0.223427316071553 no 735 0.209384225477567 1064 688761
SGTC_352 k048-0007 5.11 µM 0.807022366386363 0.223872126537915 no 736 0.209826798621433 1060 6811911
SGTC_2958 9077254 16.72 µM 0.806725158941532 0.22395817800476 no 737 0.20991242292761 1032 16457351
SGTC_1722 st034304 3.6505 µM 0.806159204347825 0.224122092690739 no 738 0.210075529012688 1043 4036148 YLR033W RSC58
SGTC_2165 5727197 32.143 µM 0.805943882088052 0.224184473322 no 739 0.210137603663713 1020 1361712
SGTC_2807 7945238 51.95 µM 0.8040667201172 0.224728720083598 no 740 0.210679221672966 1025 17148797
SGTC_1867 st057372 64 µM 0.803672443368227 0.224843128136011 no 741 0.210793086427864 1062 688837
SGTC_409 arachidonic acid 100 µM 0.803212097074681 0.224976749492577 no 742 0.2109260773327 1060 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.80299526241168 0.225039704095387 no 743 0.210988736428012 980 61125 An anti-inflammatory.
SGTC_2105 5350118 200 µM 0.802536270903947 0.225172998131424 no 744 0.21112140800572 1046 2133313
SGTC_245 methotrexate 289.6 µM 0.801602120424234 0.225444419430533 no 745 0.211391575332253 1026 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3222 9128301 49.47 µM 0.796919292603962 0.226807822422823 no 746 0.212748952739277 1062 4911358
SGTC_210 3551-0445 56.827 µM 0.796716475474932 0.226866977441406 no 747 0.212807856611265 1045 2865180 YOR207C RET1
SGTC_1393 3470-5649 58.2 µM 0.796647837266822 0.226886998897303 no 748 0.212827793258083 948 4108395
SGTC_2868 9035608 32.47 µM 0.796242132091839 0.2270053616217 no 749 0.212945656605812 1078 6462614
SGTC_1603 st002045 67.8 µM 0.794445612635144 0.22752990663805 no 750 0.213468029618593 1059 5887985
SGTC_848 0368-0089 85.6 µM 0.791732340917542 0.228323415980559 no 751 0.214258380303586 1056 762535
SGTC_3158 9100007 49.47 µM 0.791048018526383 0.228523794676928 no 752 0.214457985498449 1061 19297233
SGTC_3174 9107204 49.47 µM 0.789783131019707 0.228894430475174 no 753 0.214827216150117 1035 3938802
SGTC_2293 7624732 200 µM 0.789483912688578 0.228982156382343 no 754 0.214914614327382 1053 894453
SGTC_3242 9133940 49.47 µM 0.78938891564549 0.22901001190221 no 755 0.214942366171879 1114 17248444
SGTC_1870 st057514 26.5 µM 0.78913472558923 0.229084556162067 no 756 0.215016633906201 1060 5393161
SGTC_294 k038-0071 157 µM 0.786877323024192 0.229747163196991 no 757 0.215676841791362 1063 24152826
SGTC_3020 9089140 49.47 µM 0.786376990888627 0.229894169007471 no 758 0.215823329638424 1087 17217859
SGTC_3172 9105863 49.47 µM 0.785998153195905 0.230005512772288 no 759 0.215934284545616 1035 2348785
SGTC_617 3770-0098 35 µM 0.785844038166539 0.230050817183546 no 760 0.215979431587022 1023 5962639
SGTC_3072 9116419 49.47 µM 0.785071837833772 0.230277892162957 no 761 0.21620572521297 1040 17170162
SGTC_896 0964-0007 44.5 µM 0.782510165887366 0.231032080148055 no 762 0.216957406656898 1093 6756758
SGTC_2618 avocadyne 43.43 µM 0.781673218108455 0.231278786437788 no 763 0.217203322512217 1036 3015189
SGTC_2592 piperlongumine 83.33 µM 0.780227607606331 0.231705253568332 no 764 0.217628457468748 1031 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_211 3455-0679 143.504 µM 0.780082080560526 0.231748209520664 no 765 0.217671281637224 1101 748649
SGTC_3046 9092212 49.47 µM 0.779837779147324 0.231820331176577 no 766 0.217743183019008 1056 25236637
SGTC_2972 9093619 59.92 µM 0.779024096363768 0.232060633399837 no 767 0.217982760230686 1029 25236256
SGTC_541 4513-1321 94 µM 0.778930100174239 0.232088401913224 no 768 0.218010445848099 1005 747515
SGTC_569 4130-2812 160 µM 0.778593861868095 0.232187749143715 no 769 0.218109498000805 966 743552
SGTC_506 n9-isopropylolomoucine 153 µM 0.777525905994475 0.232503451476111 no 770 0.2184242781822 1072 6610355
SGTC_895 0964-0006 13.7 µM 0.777020682053224 0.2326528856996 no 771 0.218573284149597 1071 6738897
SGTC_2962 9082311 13.18 µM 0.776445543737639 0.232823064030763 no 772 0.218742981211346 1061 16459453
SGTC_1326 1431-2094 10.8 µM 0.774416489484942 0.233423995275288 no 773 0.219342267750189 1072 616278
SGTC_830 4076-0286 57.8 µM 0.772483176165327 0.233997371181027 no 774 0.219914153731515 1150 6866659
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.771289891121378 0.23435166087251 no 775 0.220267561434469 1114 688751
SGTC_783 0848-0141 92.7 µM 0.771114389051375 0.234403792961817 no 776 0.220319566229869 1012 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1312 1218-2183 165 µM 0.770600241833194 0.23455655497852 no 777 0.220471958908723 1106 6744073
SGTC_1225 1216-0074 20.6 µM 0.770002281910918 0.234734288439663 no 778 0.220649269540435 1063 4241466
SGTC_3304 9125678 46.087 µM 0.76941267747108 0.234909611256553 no 779 0.220824182509369 1034 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2132 5317594 122.667 µM 0.767934908789191 0.235349353458222 no 780 0.221262928357237 1036 794577
SGTC_2674 ligustilide 100 µM 0.767769269508058 0.235398671332106 no 781 0.221312137304882 1028 5319022 A signalling regulator.
SGTC_300 r073-0011 5.04 µM 0.767548070557455 0.235464540581385 no 782 0.221377861956805 1133 2735780
SGTC_1124 fisetin 1.16336 µM 0.765953409718923 0.235939704037939 no 783 0.22185201228835 1027 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_3041 9091929 49.47 µM 0.764748535600903 0.236299072378476 no 784 0.222210649297416 1170 25236887
SGTC_850 0388-0143 75.9 µM 0.764670178040129 0.236322453905951 no 785 0.222233984282277 1041 67273
SGTC_3256 9138902 49.47 µM 0.763604572483144 0.236640552011524 no 786 0.222551461797501 1126 17228773
SGTC_2233 sulbentine 40.3845 µM 0.761510592267068 0.237266319936132 no 787 0.223176077322591 1113 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2792 7535235 81.82 µM 0.761330723814629 0.237320114426267 no 788 0.223229776974583 1044 1281891
SGTC_1131 3454-3128 32.3 µM 0.759551045718297 0.23785273576772 no 789 0.223761495373419 1131 710982
SGTC_1294 1000-1494 117 µM 0.757977880122798 0.238324097442514 no 790 0.224232112486089 1091 712797 YDL207W GLE1
SGTC_1928 4'-methoxychalcone 40.3 µM 0.754736757141413 0.239296833710168 no 791 0.225203473534491 1144 641818
SGTC_2425 5628681 7.85 µM 0.754420813833207 0.239391771515621 no 792 0.225298288729975 1138 5714958
SGTC_680 0417-1641 114 µM 0.753126750787674 0.239780839119364 no 793 0.225686875376967 1054 2835990
SGTC_957 1187-1561 14.1 µM 0.751908168147817 0.240147528268908 no 794 0.226053142850427 1123 1538454
SGTC_408 cantharidin 100 µM 0.751902692263337 0.240149176731334 no 795 0.22605478948638 1074 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1696 st025591 34.7925 µM 0.751456935761857 0.240283388128891 no 796 0.226188854255379 1138 2787147
SGTC_1961 st076550 68.7 µM 0.750930348591462 0.24044198921603 no 797 0.226347287352086 1056 1579337
SGTC_95 0471-0001 561.058 µM 0.749877145861887 0.240759370923975 no 798 0.226664350060924 1091 4015405
SGTC_1453 4237-0541 195 µM 0.749849585204234 0.240767679363562 no 799 0.226672650457068 1110 739892
SGTC_8 0354-0001 70 µM 0.748352942152946 0.241219091778647 no 800 0.22712364939632 1162 4993152
SGTC_3169 9102970 49.47 µM 0.747355467902928 0.241520201850458 no 801 0.227424509331989 1154 17027839
SGTC_2074 5212007 75.395 µM 0.745925930503548 0.241952095579134 no 802 0.227856080071735 1060 758611
SGTC_834 0312-0008 75.7 µM 0.745755938334112 0.242003481694632 no 803 0.227907430562335 1130 6385573 YIL048W NEO1
SGTC_2034 5197015 53.07 µM 0.745614235315288 0.242046320941938 no 804 0.227950240565448 1101 780676
SGTC_2227 7312221 64.1025 µM 0.744598222505357 0.242353599418415 no 805 0.228257321406167 1144 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.743912258252114 0.24256117892113 no 806 0.228464779434067 1116 6708739 YPR165W RHO1
SGTC_636 0kpi-0074 126 µM 0.74373758029434 0.242614053559313 no 807 0.228517624679681 1087 616434
SGTC_1204 4049-0315 18.3 µM 0.742955918540561 0.242850737305035 no 808 0.228754184559502 1073 588402
SGTC_2318 6029776 164 µM 0.740449068567617 0.243610642659736 no 809 0.229513777213213 1113 818325
SGTC_2985 9022375 71.43 µM 0.738551356029363 0.244186752092127 no 810 0.230089735724693 1175 4939335
SGTC_471 1-acyl-paf 4 µM 0.73763754322712 0.244464430089486 no 811 0.230367367443128 1110 16759367
SGTC_333 3486-0131 40.1 µM 0.737105167970735 0.244626280012812 no 812 0.230529198318903 1168 6744690
SGTC_432 NS 1619 61.3 µM 0.735784539317726 0.245028019586275 no 813 0.230930915807466 1054 4552 A K+/calcium channel activator.
SGTC_550 4123-0385 25.7 µM 0.732903680962792 0.2459056163335 no 814 0.231808588941879 1140 5731123
SGTC_1546 5-methoxyflavanone 78.7 µM 0.731424063252816 0.246357007535126 no 815 0.232260085832468 1167 147795
SGTC_1695 st026914 34.495 µM 0.730113566022995 0.246757175248584 no 816 0.232660384850196 1099 3289191
SGTC_2654 protoveratrine a 100 µM 0.72814766424018 0.247358126463391 no 817 0.233261599488461 1145 5702278 A heart drug and vasodilator.
SGTC_2009 4012297 12.05 µM 0.727928560512368 0.247425152111579 no 818 0.233328659437425 1119 45595307
SGTC_1672 st016598 6.51 µM 0.725915990216082 0.248041267846207 no 819 0.233945136630988 1086 4665860 YNL267W PIK1
SGTC_1226 3909-7979 35.4 µM 0.725385211796676 0.248203893340946 no 820 0.234107871402805 1158 6615510
SGTC_2803 7707263 71.43 µM 0.723104230491947 0.248903411208223 no 821 0.234807925197624 1120 2199229
SGTC_1710 st031758 61.5 µM 0.722602847079636 0.249057313064567 no 822 0.234961959288149 1147 5394341
SGTC_2663 amphotericin b 100 µM 0.722423998124827 0.249112223790641 no 823 0.235016918442709 1146 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_982 1491-0518 27.5 µM 0.722177531390178 0.249187905275119 no 824 0.235092667750165 1118 3091256
SGTC_1003 4049-0218 100 µM 0.722036174840078 0.249231316542581 no 825 0.235136118483767 1166 295161
SGTC_2675 theaflavin digallate 100 µM 0.721531517943781 0.2493863318727 no 826 0.235291278087145 1136 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2875 9039966 71.43 µM 0.720363991027387 0.249745157158167 no 827 0.2356504573672 1193 6463691
SGTC_2386 9075165 157.42 µM 0.719979133713716 0.24986349845341 no 828 0.235768921540039 1147 16452277
SGTC_1130 3454-2858 15.9 µM 0.719167041634973 0.250113309496756 no 829 0.236019001941122 1100 715628 YIL048W NEO1
SGTC_1477 0139-0234 16 µM 0.717756060219373 0.25054766227159 no 830 0.236453855230004 1150 620880
SGTC_1941 st076221 61.8 µM 0.717700245756145 0.25056485226122 no 831 0.236471065867459 1175 2828568
SGTC_2734 clemastine 41.6 µM 0.717679483963097 0.250571246731141 no 832 0.23647746803442 1113 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2651 TUB2.036 5 µM 0.717489676678805 0.250629709898443 no 833 0.236536001983691 1263 15992207 YFL037W TUB2
SGTC_1524 corynanthine 62.1 µM 0.71589675517681 0.251120635530088 no 834 0.237027551099167 1161 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_229 benomyl 22.8748 µM 0.714079570536072 0.251681297779586 no 835 0.237588988928019 1168 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2115 tiliquinol 12.7705 µM 0.712083470912941 0.252297922391913 no 836 0.23820654454017 1138 71208 A bioactive hydroxyquinoline.
SGTC_2611 pyromycin 23.93 µM 0.711145891738979 0.252587829110151 no 837 0.238496917140751 1163 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_3085 9117376 49.47 µM 0.711133220098142 0.252591748480863 no 838 0.238500842933183 1171 16480349
SGTC_160 3453-0671 289.699 µM 0.710983619349885 0.252638022794155 no 839 0.238547193313414 1169 5322268
SGTC_325 2810-4341 181 µM 0.710759506578653 0.252707353425807 no 840 0.238616638769811 1183 774970
SGTC_162 k030-0015 37.8 µM 0.710274185774427 0.252857524666002 no 841 0.238767062246129 1226 1809920 YMR134W ERG29
SGTC_3113 9123498 49.47 µM 0.708663310860685 0.253356308982982 no 842 0.239266718912719 1229 8897275
SGTC_3353 9151644 39.2805 µM 0.708145793190289 0.253516660604736 no 843 0.23942736225251 1176 4909158
SGTC_416 estradiol valerate 100 µM 0.706979563680554 0.253878209433242 no 844 0.239789588912765 1183 13791 A steroid.
SGTC_1856 st057054 55.7 µM 0.706353936869442 0.254072274702785 no 845 0.239984029481198 1218 1266018
SGTC_3077 9117319 49.47 µM 0.706147549980883 0.254136311606727 no 846 0.240048191980485 1204 17154678
SGTC_3141 9094609 49.47 µM 0.705447483169692 0.254353588596224 no 847 0.2402659016022 1138 25236309 YDL196W YDL196W
SGTC_3333 9141820 12.094 µM 0.703542916660359 0.254945193855635 no 848 0.240858735559257 1141 1939433
SGTC_1908 st060353 56.5 µM 0.703492122585383 0.25496098159804 no 849 0.240874557106017 1205 4227716
SGTC_3135 9127742 49.47 µM 0.701774639333297 0.255495108248565 no 850 0.241409858447408 1149 3643468
SGTC_2242 6630449 61.2675 µM 0.701667048126507 0.255528587894964 no 851 0.241443413730438 1121 691249 YDR170C SEC7
SGTC_1327 1436-0082 2.18 µM 0.701245711487101 0.255659719196121 no 852 0.241574843556801 1147 15992205
SGTC_1728 st035614 33.7865 µM 0.698253974948937 0.256591837790837 no 853 0.242509188449982 1165 15945546
SGTC_2043 5101342 149 µM 0.697867514764163 0.256712373980451 no 854 0.242630025858383 1187 678451
SGTC_2657 nystatin 74.44 µM 0.697467345325809 0.256837217119732 no 855 0.242755184190813 1209 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2649 anisomycin 9.56 µM 0.697398507557884 0.256858696015157 no 856 0.24277671764361 1164 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2091 4-phenylthiadiazole 200 µM 0.696614778753951 0.257103302504378 no 857 0.243021952260062 1193 270010
SGTC_1387 3342-1166 1.8 µM 0.695398980493473 0.25748300006286 no 858 0.243402649643885 1157 3418228
SGTC_1272 0839-0021 27 µM 0.6947859216881 0.257674570639759 no 859 0.243594736099957 1187 5027250
SGTC_3175 9106517 49.47 µM 0.693891630963188 0.257954154114903 no 860 0.243875086205586 1188 41468073
SGTC_2441 5730946 39.09 µM 0.69324964180466 0.258154957158793 no 861 0.244076449912607 1202 1774275
SGTC_2673 kobusone 100 µM 0.69305617719711 0.258215485410752 no 862 0.24413714881267 1265 6710676 An epoxy ketone and protein crosslinker.
SGTC_2881 9058953 51.95 µM 0.692344062288217 0.258438344407614 no 863 0.244360642689097 1186 17122249
SGTC_1032 k061-1018 98.7 µM 0.692186185430808 0.258487766045213 no 864 0.244410206517968 1270 4005393
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.692165012077755 0.258494394505967 no 865 0.244416854088116 1203 2374 Ca(2+)-ATPase inhibitor.
SGTC_2923 7992654 58.14 µM 0.691972086327637 0.258554795266711 no 866 0.244477429400766 1213 2985126
SGTC_2601 securinine 100 µM 0.689060668342942 0.259467182061278 no 867 0.245392544976685 1186 442872 A GABA receptor antagonist.
SGTC_1676 st018489 23.4 µM 0.689050404858476 0.259470401394281 no 868 0.245395774243436 1204 3696235
SGTC_1748 st037455 53.6035 µM 0.688739896756658 0.259567807794369 no 869 0.245493482219508 1188 580690
SGTC_2360 9040895 200 µM 0.68813923478015 0.259756289047376 no 870 0.245682552591104 1167 4914414
SGTC_1353 1498-1206 8.11 µM 0.688090239281196 0.259771666421688 no 871 0.245697978352919 1254 6756808
SGTC_3337 9144342 33.5465 µM 0.68759511486551 0.259927088959025 no 872 0.245853892694345 1210 17682949
SGTC_747 3448-8087 38.7 µM 0.687348651069517 0.260004473305804 no 873 0.245931523768019 1219 5168703
SGTC_2984 9022109 38.96 µM 0.687304839592861 0.260018230413515 no 874 0.245945324867292 1246 6459207
SGTC_2929 9013348 24.6 µM 0.687093173139445 0.260084700435695 no 875 0.24601200799289 1202 2995952
SGTC_2401 5128683 200 µM 0.686433274889996 0.26029198576348 no 876 0.246219963729004 1165 708373
SGTC_1142 3253-1408 9.78 µM 0.68412718678285 0.261017035390771 no 877 0.246947427908308 1200 256655
SGTC_2394 5221648 200 µM 0.682326746476833 0.261583826904259 no 878 0.247516182122177 1268 788586
SGTC_2692 st077426 47.7 µM 0.682137612541698 0.261643404269088 no 879 0.24757596961615 1201 25238571
SGTC_1942 st076330 65.2 µM 0.681838133255813 0.261737754762513 no 880 0.247670654369547 1255 24208414
SGTC_1310 1188-0297 994 nM 0.679771848526658 0.262389209993926 no 881 0.248324467194655 1178 1588352
SGTC_2037 5169046 200 µM 0.679733654446377 0.262401259578606 no 882 0.248336561202401 1228 5718022
SGTC_2304 7443016 91.4 µM 0.678215068509057 0.262880577173248 no 883 0.248817669886802 1174 939854
SGTC_3216 9129716 49.47 µM 0.677211354668017 0.26319762910322 no 884 0.249135932250679 1189 8056934
SGTC_2273 7815444 169.05 µM 0.676733154738976 0.263348750998107 no 885 0.249287638283165 1195 2824616
SGTC_1161 k007-0610 110 µM 0.675285360454922 0.263806556413211 no 886 0.249747241550494 1265 5843850
SGTC_2245 6637752 200 µM 0.674717343789134 0.263986279103545 no 887 0.249927681639581 1198 681890
SGTC_2417 cerulenin 830 nM 0.674075387341454 0.264189471714755 no 888 0.250131693206205 1290 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2797 7859098 81.82 µM 0.673173345750236 0.264475121244946 no 889 0.250418508141688 1252 972681
SGTC_777 1315-0167 517 µM 0.671730180902748 0.264932454941576 no 890 0.250877741976296 1203 4221767
SGTC_1656 st012921 11 µM 0.671536877319894 0.264993742651372 no 891 0.250939287528598 1179 6732821
SGTC_1197 1601-0112 267 µM 0.671502629540418 0.265004601804324 no 892 0.250950192445799 1231 7350313
SGTC_159 3970-0959 50 µM 0.67126879827054 0.265078750156779 no 893 0.251024653919753 1314 6615653
SGTC_2507 purpurin 79.67 µM 0.670252446515771 0.265401159690029 no 894 0.25134843782054 1226 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1929 genistein trimethyl ether 50.5 µM 0.669895545754366 0.265514423794549 no 895 0.251462189707642 1252 136420
SGTC_1825 st052143 62.6 µM 0.669529316208737 0.265630673917868 no 896 0.251578943152719 1251 674173
SGTC_1181 1222-0449 220 µM 0.669273605074213 0.265711858122352 no 897 0.25166048046494 1289 658318
SGTC_3005 9076496 71.4286 µM 0.669261951864638 0.265715558130109 no 898 0.251664196597263 1254 21368410
SGTC_2099 5377090 177.372 µM 0.668246182849926 0.26603817504649 no 899 0.25198823002947 1229 2243829
SGTC_171 k064-0041 9.68 µM 0.668244068975273 0.26603884663795 no 900 0.251988904591452 1199 53325
SGTC_1680 diphenhydramine 100 µM 0.666319210596198 0.266650742601537 no 901 0.252603544549597 1258 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1037 k284-1091 78.7 µM 0.666234745147992 0.266677609730086 no 902 0.252630533877223 1218 3334711
SGTC_2942 9052777 62.25 µM 0.664958865564902 0.267083613316965 no 903 0.2530384016209 1334 6469503
SGTC_1367 1812-0510 76.9 µM 0.664536592103808 0.267218055628078 no 904 0.253173468466352 1244 1142582 YDR527W RBA50
SGTC_1230 0170-0365 3.77 µM 0.663169321986387 0.267653597686459 no 905 0.253611058495197 1326 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_890 0929-0006 47.2 µM 0.66268298500116 0.267808605905018 no 906 0.253766804684037 1235 1378169
SGTC_614 0462-0418 107 µM 0.662610454961107 0.267831726985786 no 907 0.253790036249878 1151 5188303
SGTC_2995 9067767 71.4286 µM 0.662545118999755 0.267852555603513 no 908 0.253810964488962 1240 11673567
SGTC_2798 7813637 45.45 µM 0.662110598226729 0.267991098342794 no 909 0.253950172057601 1237 956368
SGTC_1491 4138-0063 26.5 µM 0.66124829803149 0.268266141212593 no 910 0.25422654607054 1217 23883227
SGTC_721 1187-1332 279 µM 0.659434515695477 0.26884513592968 no 911 0.254808391969927 1198 25730
SGTC_415 dibenzyl ketone 100 µM 0.657820032850493 0.269361037740809 no 912 0.255326890102799 1261 7593
SGTC_2322 7413319 38.22 µM 0.654624460056461 0.270383632219644 no 913 0.256354785857731 1283 1840400
SGTC_254 nsc-64875 3.808 µM 0.653605164148085 0.270710218169967 no 914 0.256683108151972 1285 56993
SGTC_50 0929-0078 56.389 µM 0.653491311624086 0.270746709139438 no 915 0.256719794429603 1189 1377751
SGTC_82 0054-0107 293.755 µM 0.652943793394567 0.270922228968552 no 916 0.256896257325238 1275 3104697
SGTC_1007 4101-0031 70 µM 0.651760268034168 0.271301829734876 no 917 0.257277918296332 1244 1146276
SGTC_1427 4048-4900 550 nM 0.650992627889092 0.2715481822348 no 918 0.257525622888714 1260 24132586
SGTC_843 0310-0051 143 µM 0.650907309474034 0.271575569656447 no 919 0.257553161356416 1264 2065037
SGTC_2185 6113692 200 µM 0.650260337177886 0.271783294111324 no 920 0.257762036207881 1267 874150
SGTC_1250 0485-0349 40.2 µM 0.647358657688901 0.272715912566444 no 921 0.258699923106102 1265 6842794 YDL195W SEC31
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.646077549765707 0.273128173626226 no 922 0.259114566899167 1243 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1276 0871-0068 94.2 µM 0.645773269157651 0.273226136620778 no 923 0.259213100929658 1241 3414906
SGTC_517 1365-0151 113 µM 0.644782085465174 0.273545368386749 no 924 0.259534206413857 1309 768657
SGTC_2399 5884133 200 µM 0.643401203050331 0.273990418412498 no 925 0.259981901505661 1276 722445
SGTC_1209 2323-2347 50.3 µM 0.642852087256298 0.27416749449547 no 926 0.260160040632409 1246 5412760
SGTC_555 4296-0685 37 µM 0.642291081882611 0.274348463028321 no 927 0.260342101819374 1255 2908540 YHR072W ERG7
SGTC_1937 st074714 47.2 µM 0.642131915555829 0.274399817473809 no 928 0.260393767482127 1229 17250970
SGTC_311 1315-0136 58 µM 0.641825242526327 0.274498777805072 no 929 0.260493328962451 1332 6759207
SGTC_1178 0988-0033 191 µM 0.640635339269179 0.274882914373387 no 930 0.260879816868025 1288 5392207
SGTC_1741 st038134 10.228 µM 0.64039626915473 0.274960125347917 no 931 0.260957503880398 1348 1272587
SGTC_2607 solasodine 47.35 µM 0.639460676799384 0.275262390436368 no 932 0.261261643564732 1289 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2853 9015042 58.44 µM 0.637928693535807 0.275757686535383 no 933 0.261760049254836 1221 6457456
SGTC_947 3447-0010 211 µM 0.637570590003393 0.27587352591534 no 934 0.261876622676353 1292 748350
SGTC_2485 5633444 17.78 µM 0.636299679210607 0.276284833190728 no 935 0.26229055700138 1263 5724239
SGTC_1311 1190-0148 100 µM 0.635909470108046 0.276411177647878 no 936 0.262417714911889 1336 1961333
SGTC_1233 0325-0408 14.2 µM 0.635717175785492 0.27647345038334 no 937 0.262480389702509 1332 12874
SGTC_3329 9141233 27.5565 µM 0.635041924214037 0.276692178828367 no 938 0.262700536192658 1287 4909101 YNL103W MET4
SGTC_62 0180-0423 3.232 µM 0.633763037995015 0.277106669691632 no 939 0.263117739232248 1266 30102 YGL099W LSG1
SGTC_2081 5214970 32.255 µM 0.633219979669632 0.277282768385338 no 940 0.26329500009367 1270 2063512
SGTC_903 1134-0042 114 µM 0.632142187164085 0.277632428506958 no 941 0.263646985252788 1285 701009
SGTC_3355 9151058 44.0485 µM 0.628459963009087 0.278828647349654 no 942 0.264851333278741 1292 17015728
SGTC_2462 5162487 171.77 µM 0.628417394691894 0.278842490878822 no 943 0.264865272466391 1266 2259986
SGTC_3025 9087895 49.47 µM 0.627928155784558 0.279001618969423 no 944 0.265025502721668 1297 17173641
SGTC_70 0141-0289 43.283 µM 0.623127952639739 0.280565254097962 no 945 0.266600221098505 1354 352408
SGTC_1189 1431-2119 7.28 µM 0.621880106340359 0.280972425335011 no 946 0.267010353557191 1319 3107275
SGTC_3052 9092717 49.47 µM 0.62060624726252 0.281388378853811 no 947 0.267429364107353 1301 25237534
SGTC_2415 st077333 57.7 µM 0.620282767967942 0.281494051922066 no 948 0.267535818949528 1395 2766255
SGTC_1548 st061468 90.8 µM 0.619356636574519 0.281796703069438 no 949 0.267840720619548 1302 390799
SGTC_572 0960-0087 17.7 µM 0.61913504299399 0.281869141040122 no 950 0.267913699766797 1281 6796365
SGTC_391 gliotoxin 8.33 µM 0.618519760151609 0.282070321335612 no 951 0.268116388171782 1359 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_3245 9134821 49.47 µM 0.618085197181377 0.282212452932573 no 952 0.268259589759848 1265 17014901
SGTC_1441 4106-0040 13 µM 0.616272408914488 0.282805729301298 no 953 0.268857372849876 1298 2904180
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.616187508131228 0.282833529701859 no 954 0.268885386029623 1346 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1697 st025554 27.742 µM 0.615659251882242 0.283006534450326 no 955 0.269059718136558 1277 1269519
SGTC_288 1315-0019 35.1 µM 0.615370502944762 0.283101121647178 no 956 0.269155033381387 1348 6811474
SGTC_1052 3253-3998 198 µM 0.61287048795215 0.283920699996299 no 957 0.269980989230792 1289 5450317
SGTC_1624 st003710 6.25 µM 0.612000137358085 0.284206292722748 no 958 0.270268833342021 1341 24207033
SGTC_1907 st060210 83.7 µM 0.611144883663999 0.28448706535536 no 959 0.270551833971816 1352 688793
SGTC_1480 1070-0044 41.2 µM 0.610461508502232 0.284711506893654 no 960 0.270778066911801 1352 3124987
SGTC_810 3825-7150 143 µM 0.610268090929413 0.284775046549238 no 961 0.270842115392845 1353 22330411 YGL099W LSG1
SGTC_2079 5212404 121 µM 0.609240748527106 0.28511265244102 no 962 0.271182437236154 1354 758462
SGTC_1628 st004252 77.7 µM 0.607752813591994 0.285601956528269 no 963 0.271675714654491 1374 692968
SGTC_647 0140-0236 81 µM 0.606232895901357 0.286102190302926 no 964 0.272180055693846 1340 990837
SGTC_1782 st039423 80.636 µM 0.606163420098624 0.286125066054031 no 965 0.272203120361162 1293 2068169
SGTC_357 1325-0123 420 µM 0.60555677716268 0.286324847510773 no 966 0.2724045557344 1334 1098503
SGTC_1688 st021091 57.6 µM 0.603048795617302 0.287151485499164 no 967 0.273238114258852 1340 3656366
SGTC_1134 3477-0009 42.5 µM 0.601401768314626 0.287694964371221 no 968 0.273786210589249 1471 3973534
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.600063716830487 0.288136846282793 no 969 0.274231886140397 1383 364106
SGTC_1787 fluconazole 80 µM 0.599982553156381 0.288163660302718 no 970 0.274258931498039 1250 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1560 lithocholic acid 53.1 µM 0.599911330008853 0.288187191243475 no 971 0.274282665558617 1303 9903 A bile acid which acts as a detergent.
SGTC_2340 7987427 183.45 µM 0.599610085260549 0.288286727510748 no 972 0.274383062130573 1356 2239331
SGTC_2102 5377816 72.7585 µM 0.597850930530516 0.288868304971502 no 973 0.274969701916677 1380 1379702
SGTC_2133 5320837 200 µM 0.592617905466876 0.290601602253313 no 974 0.276718446659545 1381 2841355
SGTC_395 anisomycin 6.25 µM 0.590854436725585 0.291186797537049 no 975 0.277308978501935 1305 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1021 4476-0760 85.3 µM 0.590774486238726 0.291213341603386 no 976 0.277335766076154 1314 746768
SGTC_1469 k284-2957 126 µM 0.590702566285977 0.29123722044683 no 977 0.27735986408452 1385 23884841
SGTC_1335 1486-0900 202 µM 0.589760818646401 0.291549983559273 no 978 0.277675507156915 1345 X1335
SGTC_1257 0669-0121 16 µM 0.589480237020081 0.291643197590746 no 979 0.277769582874739 1392 4307855
SGTC_3036 9090181 49.47 µM 0.589259650642263 0.291716489924114 no 980 0.277843553817777 1385 25236586
SGTC_1045 1348-1485 165 µM 0.588649206024728 0.291919361827167 no 981 0.278048309069162 1354 6810614
SGTC_47 0149-0135 24.25 µM 0.588513127960105 0.291964594238639 no 982 0.278093962387573 1275 5239155
SGTC_1659 st012954 42.1 µM 0.585232292377473 0.293056132013431 no 983 0.279195767145705 1358 24207262
SGTC_754 3474-0146 171 µM 0.583821560873475 0.29352606527669 no 984 0.279670185337658 1289 24762078
SGTC_2299 7976368 114.88 µM 0.582773699341317 0.293875347485404 no 985 0.280022826183216 1436 2979718
SGTC_2161 5662504 8.5105 µM 0.582237995846582 0.294053987008484 no 986 0.280203191756542 1331 2859334
SGTC_785 1270-0111 65.3 µM 0.58218824643413 0.294070579350667 no 987 0.280219944701497 1340 6741994
SGTC_2499 avocadenofuran 51.48 µM 0.582034377760356 0.294121900116376 no 988 0.280271762523656 1303 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1766 st045414 44.774 µM 0.581171736051671 0.294409698934449 no 989 0.280562357313993 1369 253960
SGTC_1759 st043059 70 µM 0.581072496942203 0.294442815916626 no 990 0.280595796959746 1344 669426
SGTC_423 5-fluorouracil 457 µM 0.578658249543236 0.295249001175063 no 991 0.281409896188756 1306 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2924 9010168 62.78 µM 0.57824652731815 0.295386588177844 no 992 0.281548845165264 1381 2993929
SGTC_2100 5377183 190 µM 0.577060045262963 0.295783244922845 no 993 0.281949446886447 1413 2844202
SGTC_3284 9108171 64.8615 µM 0.576704641042046 0.29590210889579 no 994 0.282069498364736 1381 8687505
SGTC_2704 st078022 71.1 µM 0.573686981436163 0.296912239551565 no 995 0.283089819757158 1448 54697681
SGTC_2137 5261020 140 µM 0.573465942122812 0.296986292178234 no 996 0.283164626427809 1336 763655
SGTC_1273 0849-0096 14.1 µM 0.57266376970817 0.297255107049693 no 997 0.283436186493099 1369 5286025
SGTC_174 3553-0389 74.3 µM 0.571485516185269 0.297650151413631 no 998 0.283835287799362 1391 738071
SGTC_3264 9137442 49.47 µM 0.571191450582071 0.297748782956631 no 999 0.283934936451006 1448 17015726
SGTC_1025 k007-0731 70 µM 0.570746007293957 0.297898215964497 no 1000 0.284085913639513 1348 6256118
SGTC_248 streptozotocin 5.23457 mM 0.57054371858638 0.297966089112797 no 1001 0.28415448943303 1424 5300 DNA alkylating agent.
SGTC_2965 9082772 38.63 µM 0.569476369992003 0.298324329122367 no 1002 0.284516451208104 1433 16459634
SGTC_1587 estradiol valerate 56.1 µM 0.56871006426263 0.298581649335501 no 1003 0.284776458355334 1391 13791 A steroid.
SGTC_1000 4048-0884 8.67 µM 0.568125681836068 0.298777948767511 no 1004 0.284974815194464 1397 13040088
SGTC_2023 5144124 124 µM 0.568063321372186 0.298798899683954 no 1005 0.2849959860875 1369 2830192
SGTC_1665 st014639 11.4 µM 0.567697478320502 0.298921823491512 no 1006 0.285120202065634 1445 981133 YIL048W NEO1
SGTC_3122 9126309 49.47 µM 0.565254626382515 0.29974321349604 no 1007 0.28595029295643 1419 17591206
SGTC_270 tamoxifen 5.46 µM 0.564094831323092 0.30013354311322 no 1008 0.286344797733543 1496 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2975 9084847 53.72 µM 0.563880420647797 0.300205728304264 no 1009 0.286417757902667 1418 27211724
SGTC_192 3455-0609 60.9 µM 0.562252446439474 0.30075407082492 no 1010 0.286972016406298 1415 3769639
SGTC_2419 paclitaxel 166.5 µM 0.562160434489757 0.300785076245034 no 1011 0.287003357868205 1321 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3134 9127454 49.47 µM 0.561068766244629 0.301153047512785 no 1012 0.287375329747621 1458 24262820
SGTC_370 0180-0345 38.7 µM 0.559464169589642 0.301694280635046 no 1013 0.287922488965243 1379 3989527
SGTC_2409 alverine citrate 63.97 µM 0.559445667286913 0.301700524042641 no 1014 0.287928801023166 1520 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2905 7799065 20.05 µM 0.558965334146453 0.301862627739424 no 1015 0.288092689466036 1411 1296806
SGTC_2762 leflunomide 42.06 µM 0.558680486781853 0.301958777026947 no 1016 0.288189899449413 1419 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_657 3534-0529 86.7 µM 0.557123495832776 0.302484577119543 no 1017 0.28872152768514 1479 1049549
SGTC_806 3966-4455 5.86 µM 0.556086557992853 0.302834981419298 no 1018 0.289075841896478 1333 714982
SGTC_479 n-linoleoylglycine 10 µM 0.554563109342012 0.303350117899098 no 1019 0.28959676396896 1401 6433346 An anti-infammatory.
SGTC_690 glyoxal 20.3 µM 0.552188285674526 0.30415391694586 no 1020 0.290409679690728 1313 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_912 3474-0017 2.18 µM 0.550566495034273 0.304703383993795 no 1021 0.290965441070195 1494 3360550
SGTC_1456 k015-0012 13 µM 0.54991449826853 0.304924406575722 no 1022 0.291189009771177 1496 2989616
SGTC_1739 st037196 92.5 µM 0.549680653508922 0.3050036957497 no 1023 0.29126921432168 1460 612214
SGTC_2028 5153890 36.43 µM 0.548292138008282 0.305474684803097 no 1024 0.291745662446274 1380 2830968 YPR165W RHO1
SGTC_2201 6605497 169.863 µM 0.547583259248495 0.305715263087728 no 1025 0.291989043442588 1446 670741
SGTC_1409 3909-8004 61.9 µM 0.545218832317819 0.306518305052228 no 1026 0.292801510371858 1420 2119279
SGTC_1347 1493-0251 600 nM 0.545112472377055 0.306554450487356 no 1027 0.29283808254599 1452 3986378
SGTC_2867 9039098 71.43 µM 0.544265238120374 0.306842442332589 no 1028 0.293129482198096 1385 6463460
SGTC_2626 ethyl orsellinate 100 µM 0.542289938131753 0.307514349172008 no 1029 0.293809393017815 1384 75653 A natural product.
SGTC_3032 9089427 49.47 µM 0.542167644028951 0.307555969309524 no 1030 0.293851511399199 1393 17173707
SGTC_571 k831-0106 44.2 µM 0.541415204738126 0.307812100151426 no 1031 0.294110714724395 1491 4783639
SGTC_3101 9120531 49.47 µM 0.540928209393774 0.307977923640424 no 1032 0.294278533153319 1481 24824904
SGTC_345 1362-0200 395 µM 0.540840695647801 0.30800772651143 no 1033 0.294308695047602 1399 1419823
SGTC_1102 cgs 12066b 26.1 µM 0.540549346539633 0.30810695478999 no 1034 0.29440911974268 1419 6438352 A 5-HT1B full agonist.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.540493851014489 0.308125857160808 no 1035 0.294428250207035 1431 7104
SGTC_483 fpl-64176 144 µM 0.539433694503912 0.30848705551325 no 1036 0.294793818395291 1442 3423
SGTC_1648 st011736 69.8 µM 0.539068677010828 0.308611460947495 no 1037 0.294919733866812 1480 2855514
SGTC_542 3381-0244 89.3 µM 0.538614580067089 0.308766257150557 no 1038 0.295076412536493 1521 1112843
SGTC_284 0988-0104 32.6 µM 0.53728607331773 0.309219324229559 no 1039 0.295535011900298 1453 4666532
SGTC_2119 5528445 120.635 µM 0.537264727248751 0.309226606353859 no 1040 0.295542383219149 1486 791935
SGTC_2097 5376186 200 µM 0.537142093763417 0.309268443718801 no 1041 0.295584733193995 1473 742755
SGTC_2521 angolensin 13.4 µM 0.536416731449758 0.309515957260947 no 1042 0.29583528523696 1465 821428 A flavenoid.
SGTC_3163 9099914 49.47 µM 0.535937976169152 0.30967936906636 no 1043 0.296000708588201 1463 16268368
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.53592467992994 0.309683907960636 no 1044 0.296005303417022 1474 688788
SGTC_870 0573-2213 57.6 µM 0.535433230674844 0.309851692762106 no 1045 0.296175158254881 1402 3916321
SGTC_2371 9071574 200 µM 0.534703995506008 0.310100732623497 no 1046 0.296427279098719 1406 45596039
SGTC_1449 4112-4002 201 µM 0.531991747185654 0.311027751932889 no 1047 0.297365855705907 1353 2059539
SGTC_2471 5466956 24.79 µM 0.52971045168677 0.311808405668281 no 1048 0.298156350149793 1455 724419
SGTC_1328 1441-0025 69.2 µM 0.528981364010013 0.312058076318312 no 1049 0.298409188891374 1349 4562601
SGTC_510 ag-490 170 µM 0.528279871751519 0.312298378647034 no 1050 0.298652549943242 1535 5328779
SGTC_707 0865-0008 204 µM 0.527477456599858 0.312573350921859 no 1051 0.298931033669689 1514 723043
SGTC_1945 st075991 56.6 µM 0.526542705808283 0.312893803685873 no 1052 0.299255594049244 1376 1084980
SGTC_748 act1.228 77.9 µM 0.526406160638792 0.312940626163987 no 1053 0.299303018089272 1373 4421505 YNR035C ARC35
SGTC_2789 5281112 71.43 µM 0.526331337002503 0.312966285093123 no 1054 0.299329006826613 1396 765948
SGTC_190 3970-0790 3.722 µM 0.524315316571536 0.313657970529686 no 1055 0.300029622729106 1497 2832352
SGTC_94 0334-0113 514.748 µM 0.523951473047813 0.313782873131799 no 1056 0.30015614615176 1385 6795178
SGTC_2345 9052315 157.45 µM 0.522719449247131 0.314205968819512 no 1057 0.30058475077982 1469 6469265
SGTC_868 0527-0199 213 µM 0.519736931620573 0.315231221248394 no 1058 0.301623471177296 1472 2849450
SGTC_2735 sertaconazole 140 nM 0.519555142024131 0.315293758295906 no 1059 0.301686835148275 1517 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2123 5259487 200 µM 0.517319055751966 0.316063422000455 no 1060 0.302466726968847 1513 2173474
SGTC_1934 st074720 32.6 µM 0.515747980837221 0.316604665430521 no 1061 0.303015219288287 1425 17250992
SGTC_1015 4130-4525 82 µM 0.515414132031817 0.316719728726946 no 1062 0.30313182960652 1423 1363237
SGTC_1811 st050069 61.5 µM 0.515132799821284 0.316816705586431 no 1063 0.303230111941612 1470 3877702
SGTC_222 nsc-310342 10.666 µM 0.514929624021832 0.316886749302562 no 1064 0.303301099491099 1489 432556
SGTC_3143 9086658 49.47 µM 0.514739268934989 0.316952379105542 no 1065 0.303367614353547 1492 25236626
SGTC_1123 mangostin 811.285 nM 0.511325162032013 0.31813045650647 no 1066 0.304561694358906 1461 5281650 An antioxidant.
SGTC_1967 st070177 51.4 µM 0.510636921342578 0.318368165494069 no 1067 0.304802658771205 1529 5729214
SGTC_2760 etidronate 98.04 µM 0.50953903557434 0.318747515139513 no 1068 0.305187221968302 1422 3305 A chelator and antioxidant.
SGTC_3136 9095672 49.47 µM 0.509107574904182 0.318896648666586 no 1069 0.305338411270109 1409 17217380
SGTC_2232 chlorophetanol 41.5365 µM 0.508917023048155 0.318962521876222 no 1070 0.305405193636737 1550 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_3267 9137951 49.47 µM 0.506514115066986 0.319793690173652 no 1071 0.306247891662807 1505 16643986
SGTC_2402 5553605 200 µM 0.506289706876651 0.319871359496935 no 1072 0.306326643900253 1550 6758546
SGTC_2075 5212009 200 µM 0.505499470295662 0.320144929037664 no 1073 0.306604035201794 1501 780898
SGTC_2939 9044578 71.43 µM 0.505008697819644 0.320314877275743 no 1074 0.306776363478973 1433 2653634
SGTC_1466 k213-0079 57.5 µM 0.504530434907321 0.320480529878368 no 1075 0.306944340284779 1461 3657981
SGTC_1439 4092-1168 46 µM 0.50344367052832 0.320857077852848 no 1076 0.307326187304479 1498 2886240
SGTC_394 menadione 8.33 µM 0.501127623980678 0.321660168867179 no 1077 0.308140653399749 1475 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3124 9127567 49.47 µM 0.500974091702673 0.321713435826535 no 1078 0.308194678367749 1591 17592030
SGTC_2722 naftopidil 47.16 µM 0.500116704913432 0.322010967582444 no 1079 0.30849645217136 1511 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3231 9132313 49.47 µM 0.499094922536894 0.322365697204427 no 1080 0.308856257186058 1521 4905967
SGTC_2368 9071271 200 µM 0.496942529340641 0.323113467290015 no 1081 0.309614789660992 1446 27209959
SGTC_737 1950-0117 57.9 µM 0.496623823436684 0.3232242508475 no 1082 0.309727174994913 1507 5393513
SGTC_2656 pseudo-anisatin 100 µM 0.494427904808436 0.323987987450086 no 1083 0.310502005359983 1503 6708809 A neurotoxin.
SGTC_14 0354-0009 295 µM 0.494400649808413 0.323997471355847 no 1084 0.310511627586835 1528 1713507
SGTC_2805 7950783 58.44 µM 0.492062889733048 0.324811364894238 no 1085 0.311337442788989 1539 1178958 YDL195W SEC31
SGTC_1245 0418-0076 17.2 µM 0.491334163830037 0.325065242866347 no 1086 0.311595060153384 1524 6790114
SGTC_3308 9128332 17.569 µM 0.490925956464594 0.3252074921461 no 1087 0.311739408923723 1598 17332805 YDL196W YDL196W
SGTC_2728 chlorpromazine 9.18 µM 0.490873648047703 0.325225722063325 no 1088 0.311757908123053 1510 2726 A thorazine and dopamine antagonist.
SGTC_2894 9048625 32.47 µM 0.489956351221388 0.325545475569118 no 1089 0.312082393060369 1608 4092861
SGTC_2648 atorvastatin 78.68 µM 0.487601262472621 0.326367005690183 no 1090 0.312916150583876 1571 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_313 3474-0040 5.03 µM 0.485671204777952 0.327040900234514 no 1091 0.313600151400463 1465 1043375 YIL048W NEO1
SGTC_3147 9097027 49.47 µM 0.484388059128034 0.327489232921403 no 1092 0.314055245597281 1613 25236841
SGTC_1434 4073-0095 163 µM 0.484131329376294 0.327578964517983 no 1093 0.314146334111813 1513 24133745
SGTC_319 1348-1596 45.5 µM 0.482977403938498 0.327982404832111 no 1094 0.314555890193097 1617 5380505
SGTC_2270 7924575 90.91 µM 0.482741794510534 0.328064804301927 no 1095 0.314639541766494 1639 1262135
SGTC_1943 st076331 65.2 µM 0.482589848806883 0.32811794857287 no 1096 0.314693494133379 1533 24208415
SGTC_2173 5763948 167 µM 0.481283529845224 0.328574987926298 no 1097 0.315157500574512 1505 2867177
SGTC_1402 3909-7673 35.9 µM 0.480940360932096 0.328695094369664 no 1098 0.315279443107792 1460 5328014
SGTC_2412 st077135 33.4 µM 0.480647619812821 0.328797565466596 no 1099 0.3153834824065 1584 13258915
SGTC_19 0279-0214 38.434 µM 0.479074945668705 0.329348284457713 no 1100 0.315942656402701 1534 3566274 YBR002C RER2
SGTC_3167 9103034 49.47 µM 0.478622003231562 0.329506964587588 no 1101 0.316103781099028 1521 5127859
SGTC_3171 9103192 49.47 µM 0.47831256181178 0.329615389406433 no 1102 0.316213878429163 1549 13018434
SGTC_1653 st012112 65 µM 0.477678288441431 0.329837676474548 no 1103 0.316439599872096 1552 720429
SGTC_1309 pyrazolanthrone 13.4 µM 0.476258851663405 0.330335349126522 no 1104 0.316944988316411 1610 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1473 k844-0725 134 µM 0.475781366842397 0.330502828934139 no 1105 0.317115072967074 1543 54682906
SGTC_2808 7946468 45.46 µM 0.474651231265678 0.33089936396058 no 1106 0.317517791965378 1561 2970879
SGTC_2225 6654152 15.4 µM 0.474110024486001 0.331089326507109 no 1107 0.317710725237848 1567 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2055 5235184 200 µM 0.474047524571486 0.331111266659604 no 1108 0.317733008845235 1526 2836034
SGTC_225 nsc-122657 1.016 µM 0.473964992505198 0.331140239845619 no 1109 0.317762435691623 1519 275685
SGTC_1516 st013856 110 µM 0.473491731572424 0.331306399356895 no 1110 0.31793119931715 1502 5281404 A mutagen and neurotoxin.
SGTC_3343 9148379 18.9835 µM 0.470641401101428 0.332307837389695 no 1111 0.318948418613533 1660 1955036
SGTC_2381 9035592 200 µM 0.46827367199053 0.333140629482253 no 1112 0.319794446810756 1440 4749657
SGTC_1650 st011916 45.8 µM 0.466004230428202 0.333939624350135 no 1113 0.320606236230781 1615 242528
SGTC_226 1,3-diallylurea 8.28947 mM 0.46271564258424 0.335098762915919 no 1114 0.321784102180446 1544 74537 YKL182W FAS1
SGTC_1844 rapamycin 4 nM 0.46028560983678 0.335956294844427 no 1115 0.322655614387425 1525 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_1673 st016611 27.3 µM 0.456821559588884 0.337180197003421 no 1116 0.323899654045456 1626 5226799
SGTC_273 hydroxyurea 18.1 mM 0.455371703833862 0.337692966248236 no 1117 0.324420924325998 1568 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1053 3366-3204 134 µM 0.455340063262175 0.337704159906497 no 1118 0.32443230398186 1507 3632071 YPR165W RHO1
SGTC_1479 0549-0158 134 µM 0.453782012478216 0.338255537484786 no 1119 0.324992865694608 1551 5440202
SGTC_1206 3978-0017 132 µM 0.453378373522022 0.338398437660718 no 1120 0.325138153228504 1631 3873677
SGTC_1182 1222-0449 220 µM 0.452883328299646 0.338573730147605 no 1121 0.325316378227503 1567 658318
SGTC_712 r015-0009 80.6 µM 0.451788873416724 0.338961394035063 no 1122 0.325710543047823 1608 6813872 YLR060W FRS1
SGTC_974 1326-0144 138 µM 0.45115081157216 0.33918747893504 no 1123 0.32594042919122 1524 5411856
SGTC_233 rapamycin 362 pM 0.450934297273953 0.339264209762226 no 1124 0.326018451778094 1578 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2892 9047358 58.44 µM 0.449317530593209 0.339837388679161 no 1125 0.326601306677035 1526 6466771
SGTC_212 3807-4682 38.772 µM 0.448865121625779 0.339997843886194 no 1126 0.326764478947437 1653 3125501 YBL034C STU1
SGTC_669 0108-0021 26.2 µM 0.447477961136597 0.34049000659905 no 1127 0.327264998498307 1828 17201
SGTC_2098 5376439 882.5 nM 0.447121932090431 0.340616369094826 no 1128 0.327393512152799 1659 2844116
SGTC_665 3914-0008 307 µM 0.444201771004157 0.341653472178071 no 1129 0.328448355975259 1508 1069549
SGTC_2720 fluspirilene 36.88 µM 0.443655960614559 0.341847451159667 no 1130 0.328645670037032 1603 3396 An atypical antipsychotic.
SGTC_546 peri-Naphthalide 147 µM 0.443392095000019 0.341941242995103 no 1131 0.328741076337656 1651 223824 A penicillin ester.
SGTC_157 1348-1695 65.819 µM 0.440784385083733 0.342868685202134 no 1132 0.329684549501572 1542 5380510
SGTC_526 4469-0568 170 µM 0.439701932607456 0.343253942316455 no 1133 0.330076501337641 1527 2901964
SGTC_3215 9129942 49.47 µM 0.435956778375806 0.344588140276902 no 1134 0.331434044437299 1644 17682944
SGTC_367 0335-0881 7.1 µM 0.435920605690321 0.344601036132313 no 1135 0.331447167149496 1642 23828853
SGTC_1982 st072467 71.9 µM 0.435844167427276 0.344628287586351 no 1136 0.331474898072242 1550 3163533
SGTC_2383 9036125 200 µM 0.433290646783838 0.345539120842456 no 1137 0.332401816125001 1610 79580
SGTC_579 4491-1009 110 µM 0.433287784705569 0.345540142240412 no 1138 0.332402855624891 1735 1271041
SGTC_1364 1653-0028 37.6 µM 0.431869201146838 0.346046534442022 no 1139 0.332918240257471 1585 5718652
SGTC_1612 st002233 45.4 µM 0.429819755443963 0.346778611943219 no 1140 0.333663380532111 1588 1035021
SGTC_3055 9094636 49.47 µM 0.429219161188691 0.346993257333913 no 1141 0.333881869945603 1623 25236176
SGTC_729 4092-0585 94.1 µM 0.426901022717062 0.34782219302448 no 1142 0.334725710299383 1533 2169061
SGTC_2189 6047310 154.431 µM 0.42638514185836 0.348006764365131 no 1143 0.334913613162306 1559 711535
SGTC_3159 9100096 49.47 µM 0.425613957334489 0.348282745148682 no 1144 0.335194584120926 1512 25236875
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.423945154082691 0.348880228137956 no 1145 0.335802906255981 1554 16623 A steroid.
SGTC_2465 5809242 33.21 µM 0.423938012233264 0.348882785946844 no 1146 0.335805510571802 1655 2731748
SGTC_2436 5633522 8.09 µM 0.42352264965319 0.349031557278233 no 1147 0.335956988449112 1703 5724242
SGTC_175 3793-3120 23.7 µM 0.42259552986637 0.349363709500338 no 1148 0.336295194293698 1572 5322297
SGTC_1432 4049-0298 68.4 µM 0.42247039825268 0.349408548304585 no 1149 0.336340851456712 1704 741646
SGTC_2374 9071832 200 µM 0.421327650257706 0.349818129945552 no 1150 0.336757921088841 1568 17381698
SGTC_2188 6126565 140.678 µM 0.42130265441166 0.349827090866475 no 1151 0.336767046088763 1638 874518
SGTC_919 tnp00227 403.569 nM 0.421153610068164 0.349880524463971 no 1152 0.336821458309001 1618 1269246 A methoxyflavone. YNL221C POP1
SGTC_2773 thioridazine 9.09 µM 0.418262694908488 0.350917527800018 no 1153 0.337877530799807 1611 5452 An antipsychotic.
SGTC_390 dec-rvkr-cmk 16.7 µM 0.417204940716763 0.351297234108022 no 1154 0.338264255824317 1628 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1797 st048695 56.8 µM 0.416747310558162 0.351461557496321 no 1155 0.338431622699266 1689 592262 YIL048W NEO1
SGTC_1255 0566-0045 221 µM 0.414887226487073 0.352129752021765 no 1156 0.339112230560436 1666 2788469
SGTC_2854 9024559 71.43 µM 0.414250697990301 0.352358515976421 no 1157 0.339345258166762 1549 3163529
SGTC_1333 1482-0047 286 µM 0.411313864876692 0.35341468428302 no 1158 0.340421202140389 1697 3811116
SGTC_990 3985-0011 41.3 µM 0.410347507972075 0.353762461011532 no 1159 0.340775523302857 1603 5399565 YGL099W LSG1
SGTC_2587 piperic acid 92.2 µM 0.41002151779483 0.353879807326162 no 1160 0.340895081474578 1568 5370536
SGTC_726 3448-4391 34.2 µM 0.409382720102043 0.354109794854053 no 1161 0.341129409357595 1732 1356692
SGTC_161 4065-0411 162.148 µM 0.409213994529899 0.354170550327347 no 1162 0.341191312593506 1671 1906281 YLR208W SEC13
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.406777742134604 0.355048220290515 no 1163 0.342085617861867 1613 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2080 5212524 12.4 µM 0.405551376150771 0.355490315225407 no 1164 0.342536130973157 1733 260183
SGTC_1662 st014054 52 µM 0.405493486535571 0.355511188771516 no 1165 0.342557402624354 1597 2838777
SGTC_1968 st069590 43.6 µM 0.403629797083484 0.35618341978161 no 1166 0.343242485394406 1694 6384066
SGTC_1044 1222-0021 1.78 µM 0.401186039920246 0.357065558133131 no 1167 0.344141578996261 1650 4306703
SGTC_2842 9000675 19.48 µM 0.400969569077446 0.357143735906239 no 1168 0.344221264335983 1526 2989072
SGTC_2297 7971671 152.32 µM 0.400200486803706 0.357421536071343 no 1169 0.344504428047282 1720 909016
SGTC_1600 coumarin 106 71.1 µM 0.397731536599365 0.358313855509384 no 1170 0.34541404414038 1667 100336 A hepatotoxic, DNA x-linker.
SGTC_2989 9073649 71.4286 µM 0.397488842111819 0.358401611187581 no 1171 0.345503506496324 1732 21367202
SGTC_2460 5552655 174.22 µM 0.396816783343101 0.358644659321341 no 1172 0.345751286696302 1576 5401989
SGTC_1019 4262-0212 3.4 µM 0.395808937525575 0.35900925117625 no 1173 0.346122991487647 1705 4677213
SGTC_1950 st077106 7.18 µM 0.393094726780606 0.359991764721327 no 1174 0.347124759341571 1600 13831864
SGTC_2272 7805186 180 µM 0.393057333629583 0.360005307097605 no 1175 0.34713856798379 1694 2956062 YPR165W RHO1
SGTC_396 dithiazanine 1.25 µM 0.391119671323513 0.360707294751173 no 1176 0.3478543904372 1597 10578 An antihelmenthic.
SGTC_2718 lomofungin 53.02 µM 0.389789929770237 0.361189313196496 no 1177 0.348345945424685 1754 5351222 A RNA synthesis inhibitor.
SGTC_2790 5423970 71.43 µM 0.389016328740008 0.361469837580711 no 1178 0.348632033672773 1750 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2889 9059656 51.95 µM 0.387534885682697 0.362007248510819 no 1179 0.349180131805919 1692 3949838
SGTC_923 1900-2434 73.3 µM 0.387247949922913 0.36211136933653 no 1180 0.349286327521576 1592 5910570
SGTC_2113 5491891 107.031 µM 0.387169396369636 0.362139875966196 no 1181 0.349315402466027 1581 789979
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.385979629851475 0.362571728761747 no 1182 0.349755877537863 1598 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2705 st078069 42.8 µM 0.385052766394106 0.362908276149584 no 1183 0.350099160931431 1637 1530061
SGTC_2128 5255449 168.493 µM 0.383600163318053 0.363435934424774 no 1184 0.350637409473105 1608 736008
SGTC_2872 9044037 25.97 µM 0.381775056594669 0.364099272062209 no 1185 0.351314110924329 1742 6465195
SGTC_2228 7354201 200 µM 0.381067170291597 0.364356664101376 no 1186 0.351576703557481 1743 753451
SGTC_1737 st035557 69.7 µM 0.380827885140206 0.364443683571948 no 1187 0.351665483157858 1599 5716916
SGTC_1056 3448-1962 115 µM 0.378395722997061 0.365328569860828 no 1188 0.352568322486096 1688 715507
SGTC_209 4077-0173 175.592 µM 0.378063449005311 0.36544951591921 no 1189 0.352691730068819 1672 15993494
SGTC_3109 9122853 49.47 µM 0.37786223546901 0.365522763137869 no 1190 0.352766468932782 1705 1234709
SGTC_3012 9080433 71.4286 µM 0.376872872635258 0.365882989506962 no 1191 0.353134041010788 1776 17688859
SGTC_660 4031-1742 102 µM 0.375341913501875 0.36644064375878 no 1192 0.353703099203006 1657 6738706
SGTC_17 0960-0276 49.807 µM 0.37533734022501 0.366442310005211 no 1193 0.353704799582632 1676 6821114
SGTC_2732 terfenadine 20 µM 0.374051181690513 0.366911014083779 no 1194 0.354183118971717 1679 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2703 st077852 53.4 µM 0.373983451701058 0.366935701868513 no 1195 0.354208313983948 1678 6281836
SGTC_25 0118-0223 35.662 µM 0.373433805081981 0.367136070059435 no 1196 0.354412801708585 1713 5333628
SGTC_297 0986-0032 24 µM 0.373277757080343 0.367192962399922 no 1197 0.354470864663939 1658 2847425
SGTC_954 1189-0853 2.85 µM 0.372144940810835 0.367606054518926 no 1198 0.354892468725549 1657 2828194
SGTC_2483 5729050 27.16 µM 0.371845295060116 0.36771534880841 no 1199 0.355004018647999 1800 2865180
SGTC_772 k072-0172 35.3 µM 0.370500636214728 0.368205938191145 no 1200 0.355504751300012 1568 5861980
SGTC_591 4299-0174 154 µM 0.368788396603389 0.368830947948579 no 1201 0.35614272708871 1693 5509088
SGTC_1170 0310-0127 64.8 µM 0.36737223172215 0.369348145438164 no 1202 0.356670690795786 1726 774975
SGTC_866 0495-0101 262 µM 0.367187446258182 0.369415648392918 no 1203 0.356739601375877 1610 635694
SGTC_824 1304-0008 100 µM 0.366869819070019 0.369531688428965 no 1204 0.356858062493489 1686 768245
SGTC_148 3253-0744 288.01 µM 0.36592296390513 0.369877677374344 no 1205 0.357211280135699 1630 6893655
SGTC_1496 4469-0713 57.4 µM 0.365882302092326 0.369892537908521 no 1206 0.357226451481286 1767 746691
SGTC_2679 rapamycin 1 nM 0.365795331611945 0.369924323365802 no 1207 0.357258901830402 1704 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2072 5231554 129 µM 0.365198826037878 0.370142354636109 no 1208 0.357481497276923 1840 789545
SGTC_1859 st055998 20 µM 0.365063226627146 0.370191923973736 no 1209 0.357532105099605 1816 676301
SGTC_3181 9108277 49.47 µM 0.364877096394019 0.370259968726835 no 1210 0.357601575895614 1642 17097298
SGTC_11 0438-0307 1.3 µM 0.364184217767673 0.370513304224213 no 1211 0.357860225687276 1782 4011476
SGTC_302 1094-0063 18.9 µM 0.36385776782211 0.370632682780755 no 1212 0.357982111232711 1674 5440289
SGTC_1771 st048882 4.1505 µM 0.363644579930629 0.370710649581742 no 1213 0.358061716312193 1609 4580403
SGTC_2060 5238662 140 µM 0.363462640487137 0.37077719243992 no 1214 0.358129657996635 1670 790130
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.362851091044914 0.371000889949978 no 1215 0.358358061954103 1629 23665772 A membrane-active detergent.
SGTC_2294 7971431 200 µM 0.362845128452866 0.371003071209949 no 1216 0.358360289136718 1708 5741572
SGTC_1354 1498-1681 81 µM 0.362625357167174 0.371083471737694 no 1217 0.358442382767277 1698 5754243
SGTC_1173 0443-0020 122 µM 0.361607105878385 0.371456059399891 no 1218 0.35882282690698 1657 5331295
SGTC_130 0136-0219 337.655 µM 0.361403753338322 0.371530482438146 no 1219 0.35889882129539 1812 234244
SGTC_1262 0737-0114 49.6 µM 0.360211700841969 0.371966846763099 no 1220 0.359344412608921 1812 765919
SGTC_845 0330-0138 4.51 µM 0.35975619656188 0.372133632737431 no 1221 0.359514731472914 1776 9039800
SGTC_2251 lansoprazole 556 µM 0.357985223207883 0.372782314324507 no 1222 0.360177185956626 1626 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1394 3474-0001 65.7 µM 0.357903530880987 0.372812245749214 no 1223 0.36020775413231 1660 5017666 YIL048W NEO1
SGTC_950 1165-0508 94.1 µM 0.357594158618964 0.372925604266853 no 1224 0.360323525193277 1640 6148369
SGTC_1034 k072-0165 12.7 µM 0.357528268673244 0.372949748727503 no 1225 0.360348183709265 1825 5835461
SGTC_1396 3511-0007 98.6 µM 0.357376958454065 0.373005196156444 no 1226 0.360404811928923 1681 X1396
SGTC_736 0958-0254 92.6 µM 0.357281813812157 0.37304006313141 no 1227 0.360440421612145 1732 6812352
SGTC_456 gingerol 170 µM 0.356746016546531 0.373236432324482 no 1228 0.360640976475556 1722 442793 A herb.
SGTC_2916 7875993 68.79 µM 0.355178715446679 0.373811035579678 no 1229 0.361227854585331 1854 1299250
SGTC_1223 0764-0573 147 µM 0.352383528536685 0.374836501477063 no 1230 0.362275326560262 1690 1609797
SGTC_1651 st011928 86.1 µM 0.351704979926569 0.37508557341923 no 1231 0.362529762728404 1715 720198
SGTC_985 1493-0307 8.71 µM 0.351302544124444 0.375233318430516 no 1232 0.36268069324861 1829 3278274
SGTC_773 4358-1457 44.6 µM 0.350766754143823 0.375430049755371 no 1233 0.362881670364633 1849 1186886
SGTC_949 1165-0505 146 µM 0.349816406242144 0.375779078099006 no 1234 0.363238242822849 1674 6244267
SGTC_330 1488-0319 80.1 µM 0.347335375571197 0.37669074925822 no 1235 0.364169688631176 1724 6846614
SGTC_1871 st057448 67.3 µM 0.346022781699852 0.377173349232356 no 1236 0.364662796881575 1796 691747
SGTC_630 4356-0227 183 µM 0.34580590184659 0.377253107708491 no 1237 0.364744294730615 1709 779312
SGTC_2653 dihydrofissinolide 100 µM 0.34579815966364 0.377255955025581 no 1238 0.364747204156081 1742 6857746
SGTC_1494 4358-1428 177 µM 0.345151329931579 0.377493861016017 no 1239 0.364990303005019 1851 1564571
SGTC_1750 st081859 2.357 µM 0.344337061326923 0.377793417638104 no 1240 0.365296407782975 1750 5291695
SGTC_841 0251-0215 91.2 µM 0.343440544356901 0.378123317157651 no 1241 0.365633531138991 1745 3888614
SGTC_1075 aripiprazole 15.2 µM 0.342589348691202 0.378436621646946 no 1242 0.36595370809804 1694 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2330 7979373 200 µM 0.341421828599698 0.37886648746204 no 1243 0.366393022222957 1591 1863007
SGTC_2426 5582046 32.21 µM 0.340959616394852 0.379036709468109 no 1244 0.366566991724932 1755 2251934
SGTC_2261 9010538 184.68 µM 0.340734914628208 0.379119470380233 no 1245 0.366651575890183 1651 6457250
SGTC_3350 9150499 3.57 µM 0.34034201161921 0.379264195557111 no 1246 0.366799491369309 1709 4910996 YPR165W RHO1
SGTC_1483 3453-0561 55.9 µM 0.339920474565491 0.379419486854482 no 1247 0.366958208650174 1765 4546991
SGTC_15 0266-0086 27.098 µM 0.33986660191174 0.379439334565317 no 1248 0.366978494440472 1805 1712902 YIL048W NEO1
SGTC_464 bw-b 70c 158 µM 0.339761993369597 0.379477875250354 no 1249 0.367017885930392 1805 5353454
SGTC_214 4373-3496 70 µM 0.339379548841301 0.379618788600171 no 1250 0.36716191151084 1798 3779166
SGTC_593 1203-0218 61.7 µM 0.337428133701733 0.380338044567685 no 1251 0.367897089658313 1819 3666956
SGTC_688 0527-0193 473 µM 0.337416755650997 0.380342239525479 no 1252 0.367901377659237 1761 4007154
SGTC_117 lucigenin 22.078 µM 0.336482445682254 0.380686756958564 no 1253 0.368253543489493 1629 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_460 trequinsin 123 µM 0.335395360620239 0.381087727774597 no 1254 0.368663433594733 1743 5537 A vasodilator.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.334821773108597 0.381299346757421 no 1255 0.368879767505235 1751 165521
SGTC_1208 2323-2347 50.3 µM 0.332351531078599 0.382211121033403 no 1256 0.369811916461545 1854 5412760
SGTC_2714 st079313 56.9 µM 0.331692784272519 0.382454377188008 no 1257 0.370060624916169 1716 2939799
SGTC_463 ikarugamyin 104 µM 0.331186396321289 0.382641403164709 no 1258 0.37025184756194 1772 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_532 1548-0774 215 µM 0.33115201988835 0.382654100521757 no 1259 0.370264829982597 1847 5932993
SGTC_3138 9097216 49.47 µM 0.330835516126315 0.382771010992651 no 1260 0.370384366051031 1824 25237486
SGTC_2497 7-hydroxyflavone 100 µM 0.330050450876112 0.383061045256174 no 1261 0.370680920842893 1817 5281894
SGTC_2468 5987765 72.9 µM 0.329969212097803 0.383091061831696 no 1262 0.370711612808713 1778 26772094
SGTC_1071 trifluoperazine 6.31 µM 0.329785768392632 0.383158844259027 no 1263 0.370780920765966 1814 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_104 0074-0074 590.992 µM 0.328872198725541 0.383496461374696 no 1264 0.371126144352115 1824 3943124
SGTC_2903 5923464 63.88 µM 0.32884396324534 0.383506897437391 no 1265 0.371136815749261 1822 2876576
SGTC_2638 epoxomicin 18 µM 0.328134785109003 0.383769043134143 no 1266 0.371404877015225 1836 9915668 A protesome inhibitor.
SGTC_1132 3456-3614 2.5 µM 0.327460014032331 0.384018519753929 no 1267 0.371659990725894 1913 3125502
SGTC_1523 st012844 44.7 µM 0.325033841177347 0.384915921743952 no 1268 0.372577729744498 1734 4274103
SGTC_1801 st050089 28.441 µM 0.324895546685821 0.384967093260696 no 1269 0.37263006372317 1729 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_907 3448-6986 75.5 µM 0.324890309757821 0.384969031060181 no 1270 0.372632045549535 1836 590582
SGTC_2150 5556613 200 µM 0.319893250129333 0.386819375720117 no 1271 0.374524627427337 1779 743190
SGTC_1476 4112-3294 3.34 µM 0.319476246551106 0.386973903605081 no 1272 0.374682700449804 1834 704369
SGTC_2823 7987624 58.44 µM 0.316566134570575 0.388052793443804 no 1273 0.375786417889201 1756 2239440
SGTC_177 1327-0068 8.361 µM 0.314971034803473 0.388644525341671 no 1274 0.376391823118909 1739 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_87 0100-0052 35.5 µM 0.314917803508625 0.388664276944106 no 1275 0.376412031813671 1805 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2670 beta-carotene 100 µM 0.31313034681797 0.389327683936113 no 1276 0.377090817083068 1815 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3291 9121177 71.43 µM 0.312895047546749 0.389415038342952 no 1277 0.377180200143974 1730 17015612
SGTC_255 tunicamycin 200.472 nM 0.312623344719424 0.389515914452519 no 1278 0.37728341999909 1883 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_853 0419-0306 21 µM 0.312286352220448 0.389641041241443 no 1279 0.377411455569383 1717 762713
SGTC_1342 1486-1464 234 µM 0.311591482623478 0.389899085463994 no 1280 0.377675504043992 1747 3253938
SGTC_3000 9075062 71.4286 µM 0.307995993854145 0.391235065857685 no 1281 0.379042690354177 1757 17057871
SGTC_1320 1313-0481 95.3 µM 0.307770333784852 0.391318957654558 no 1282 0.379128548390544 1895 6813365 YLR208W SEC13
SGTC_3259 9138485 49.47 µM 0.306339044457867 0.3918511739535 no 1283 0.379673257028647 1877 17646153
SGTC_491 tetrandrine 80.3 µM 0.304709448856634 0.392457375666109 no 1284 0.380293726249384 1868 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_442 cape 100 µM 0.302231250358509 0.393379753455467 no 1285 0.381237891562905 1894 5281787
SGTC_859 0439-0102 54.6 µM 0.300890256140196 0.393879117332144 no 1286 0.381749090348022 1914 610143
SGTC_1927 st060202 13.8 µM 0.300862549764839 0.393889436567302 no 1287 0.38175965444005 1914 688887
SGTC_2930 9013230 14.89 µM 0.300759813325063 0.393927701388486 no 1288 0.381798827319422 1874 2995857
SGTC_1989 st071868 50.2 µM 0.300154968464191 0.394153000341275 no 1289 0.382029476101107 1913 16414057
SGTC_2103 5378138 10 µM 0.299636801712086 0.394346040699237 no 1290 0.382227104756384 1832 244142
SGTC_128 0906-2981 13.371 µM 0.299338869715141 0.394457045486197 no 1291 0.382340749834713 1876 6740226
SGTC_2817 7995342 71.43 µM 0.298107680655464 0.394915858013527 no 1292 0.382810489815048 1697 18879975
SGTC_1081 sertraline 6 µM 0.294604406194982 0.396222176947302 no 1293 0.384148047916748 1893 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2048 5246248 200 µM 0.294549447951486 0.396242679386809 no 1294 0.38416904214115 1908 677046
SGTC_318 1488-0629 67.2 µM 0.294341689183445 0.396320187396141 no 1295 0.384248409723834 1766 3662576
SGTC_3220 9131269 49.47 µM 0.293787919747968 0.396526800693157 no 1296 0.384459983300706 1800 17722206
SGTC_2724 maprotiline 69.64 µM 0.292910375305701 0.396854275058259 no 1297 0.384795329080105 1856 4011 A tricyclic antidepressant.
SGTC_795 0685-0265 78 µM 0.291811880234223 0.397264304359682 no 1298 0.385215230643744 1771 302754
SGTC_3232 9132874 49.47 µM 0.291672808834032 0.397316222895722 no 1299 0.385268400527432 1741 3784940
SGTC_3273 9137859 49.47 µM 0.29111638474154 0.397523966935761 no 1300 0.385481154578613 1853 2377234
SGTC_2254 7938975 95.19 µM 0.289868174326126 0.397990098922582 no 1301 0.385958545005898 1880 2969277
SGTC_948 3448-0295 75.3 µM 0.289670214311749 0.398064038553967 no 1302 0.386034272662234 1765 678569
SGTC_1591 genipin 88.4 µM 0.289238193398102 0.39822541449199 no 1303 0.386199553089405 1865 442424 A DNA cross-linking agent.
SGTC_1062 mesoridazine 14.2 µM 0.287878595096727 0.398733388692907 no 1304 0.386719836139822 1795 4078 A neuroleptic.
SGTC_965 1291-5240 308 µM 0.287672989217592 0.398810222283092 no 1305 0.386798533935046 1893 2834598
SGTC_1848 st056003 16.4 µM 0.285813704129953 0.399505202849293 no 1306 0.387510405701933 1985 146492
SGTC_953 1188-0045 9.7 µM 0.28400665972376 0.400180961714844 no 1307 0.388202638491896 1845 6144426
SGTC_1719 st032227 49.2 µM 0.283387163012001 0.400412696437761 no 1308 0.388440033837552 1725 3125804
SGTC_873 0591-4978 488 µM 0.283307356780899 0.400442552052569 no 1309 0.388470619159443 1973 3305145
SGTC_2597 laccaic acid a 100 µM 0.283088137826474 0.400524565141508 no 1310 0.38855463723872 1802 5491415 A textile dye.
SGTC_2794 7785382 27.27 µM 0.281398036715529 0.401157004230389 no 1311 0.389202561890964 1982 2205081
SGTC_3056 9094900 49.47 µM 0.279935976336967 0.401704319115683 no 1312 0.389763312544312 1720 25236784
SGTC_2606 farnesol 9.78 µM 0.279762526279031 0.401769262082691 no 1313 0.389829851885619 1903 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1742 st038235 28.8875 µM 0.278169812876953 0.402365730568512 no 1314 0.390441003268121 1817 564103 YBR002C RER2
SGTC_1050 3232-1156 69.3 µM 0.277991751322026 0.402432428478198 no 1315 0.390509345390993 1772 700529
SGTC_689 0833-0039 98 µM 0.277914340312448 0.402461425811635 no 1316 0.390539057703779 1919 5374726
SGTC_2848 9016370 25.97 µM 0.277496128228143 0.402618092848298 no 1317 0.390699589181156 1982 7894410
SGTC_2897 9048598 12.99 µM 0.276657131018856 0.402932437949199 no 1318 0.391021695956364 1813 6467404
SGTC_417 st075190 100 µM 0.276235986511827 0.403090250833236 no 1319 0.391183409437102 1955 222757
SGTC_1093 fluphenazine 7.97 µM 0.275570127778411 0.403339796171817 no 1320 0.391439128066808 1845 6602611 An atypical antipsychotic.
SGTC_1199 1638-0010 4.46 µM 0.275495107225886 0.403367914258164 no 1321 0.391467942155683 1774 3111136
SGTC_1553 gossypol 38.6 µM 0.275447058274541 0.40338592351305 no 1322 0.391486397234716 1858 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2591 skatole 100 µM 0.274716705754206 0.403659692563434 no 1323 0.391766947735581 1814 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2041 5107442 45.335 µM 0.274689045951469 0.403670061633096 no 1324 0.391777573809945 1933 793005
SGTC_2763 lisinopril 49.32 µM 0.274509933665582 0.403737208644457 no 1325 0.39184638538207 1937 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_788 1182-0090 188 µM 0.274120043691083 0.403883383447694 no 1326 0.391996185474347 1949 5715185
SGTC_1646 st011709 75.6 µM 0.273185503773421 0.404233809185594 no 1327 0.392355311313644 1940 5757843
SGTC_560 2332-1943 155 µM 0.273026213918418 0.40429354599873 no 1328 0.392416532517073 1831 21177716
SGTC_186 3455-3465 67.277 µM 0.272345316411995 0.404548921029573 no 1329 0.392678257554173 1844 755278
SGTC_1413 3910-0535 34.4 µM 0.271450018174524 0.404884770324688 no 1330 0.393022468317593 1916 2876951
SGTC_1906 st060206 94.7 µM 0.270967582957295 0.405065773197967 no 1331 0.393207982437642 1938 5133468
SGTC_486 niguldipine 82 µM 0.270698567921822 0.405166712658959 no 1332 0.393311439167741 1872 1236 A calcium channel blocker.
SGTC_2493 resveratrol 26.09 µM 0.270192345674603 0.405356673792601 no 1333 0.393506140524528 1798 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2234 tolnaftate 200 µM 0.269673424752139 0.405551423277555 no 1334 0.393705753642196 1912 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1527 coumarin 137 µM 0.269569340093386 0.405590488758592 no 1335 0.393745795214256 1899 323 A hepatotoxic, DNA x-linker.
SGTC_577 r071-0003 38.6 µM 0.269294670725412 0.405693583306465 no 1336 0.393851466451311 1797 4568517 YMR134W ERG29
SGTC_573 3702-0553 84.7 µM 0.269195060347323 0.405730972735935 no 1337 0.393889790646483 1827 1222756
SGTC_1457 k015-0032 57.3 µM 0.268035554742891 0.406166264197753 no 1338 0.394335975489893 1810 4302660
SGTC_1829 berberine 14.4 µM 0.267106660759734 0.406515065184305 no 1339 0.394693519656533 1940 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_74 000s-0487 160.283 µM 0.267068264390167 0.40652948467322 no 1340 0.394708300862741 1977 677548
SGTC_1462 k081-0014 26.5 µM 0.266957973484971 0.406570904358636 no 1341 0.394750759694042 1779 3270634
SGTC_49 0717-0965 32.132 µM 0.264570400529654 0.407467811493791 no 1342 0.395670212368178 1921 5889349 YGL099W LSG1
SGTC_1632 st005650 90 µM 0.262809980591522 0.408129435676494 no 1343 0.396348521241199 1845 2759605
SGTC_1875 nocodazole 6 µM 0.262362345162931 0.408297713771773 no 1344 0.396521050154922 1981 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_786 4544-0069 423 µM 0.262322139212697 0.408312829088902 no 1345 0.396536547438277 1892 748821 YLR208W SEC13
SGTC_1649 st011737 51.3 µM 0.261781206759148 0.408516204422565 no 1346 0.396745064388095 1831 1761035
SGTC_412 gemfibrozil 100 µM 0.261615826330869 0.40857838771624 no 1347 0.396808820614917 1948 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2544 sphondin 68.51 µM 0.261307764814501 0.408694225452919 no 1348 0.396927589542376 1915 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.260885306746198 0.408853091714509 no 1349 0.397090478048396 1913 616764
SGTC_2235 salicylic acid 500 µM 0.259132092361801 0.409512551496269 no 1350 0.397766662068862 1923 338 A COX inhibitor and kinase inhibitor.
SGTC_2408 sulbentine 18.36 µM 0.258774983839455 0.409646906918497 no 1351 0.397904430289723 1887 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_3199 9111318 49.47 µM 0.258625515978453 0.409703144564945 no 1352 0.397962096993503 1916 8548020
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.258103915801811 0.409899412447386 no 1353 0.398163354787257 1847 16486 A toxic proline analog.
SGTC_2768 sulfasalazine 50.2 µM 0.257686872765514 0.410056353779832 no 1354 0.398324289032007 1967 5384001 An antioxidant and salicylic acid derivative.
SGTC_2689 tacrolimus 100 µM 0.257177615661713 0.410248016580581 no 1355 0.398520831549334 1831 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1295 1013-0063 9.78 µM 0.257032872378442 0.410302495735764 no 1356 0.398576698424186 1979 6826038
SGTC_111 0083-0039 52.457 µM 0.254594926272654 0.411220360632821 no 1357 0.399517989166678 1911 759313
SGTC_3001 9076041 71.4286 µM 0.254408382278158 0.411290612865479 no 1358 0.399590037920488 1860 16004211
SGTC_612 0302-0167 22.4 µM 0.253573965527148 0.411604887949134 no 1359 0.399912355928416 1942 235821
SGTC_3324 9138759 60.749 µM 0.253531773489744 0.411620780684431 no 1360 0.399928655656961 1886 45595710
SGTC_164 4100-3994 89.624 µM 0.251132681595224 0.412524699201196 no 1361 0.400855764555825 2006 4615967
SGTC_878 0828-0289 13.7 µM 0.250733843988368 0.412675016474519 no 1362 0.401009946296842 1828 745350 YLR208W SEC13
SGTC_292 k038-0015 474 µM 0.25045622175432 0.412779656639657 no 1363 0.40111727797628 1933 46368540
SGTC_701 4424-0219 185 µM 0.24908956340289 0.41329486178389 no 1364 0.401645751139346 1996 2911779
SGTC_900 1112-0045 141 µM 0.248594420215167 0.413481558589662 no 1365 0.401837262528001 1967 56211 YIL048W NEO1
SGTC_2286 7945697 125 µM 0.247092416910407 0.414048017749392 no 1366 0.402418351122274 1795 1245733
SGTC_2706 st078239 82.5 µM 0.246568767906682 0.414245546625101 no 1367 0.402620988974171 1917 15434492
SGTC_1891 st059073 26.2 µM 0.245925960045222 0.414488053804053 no 1368 0.402869773815607 2014 688754
SGTC_1440 4100-1550 40 µM 0.245723736800724 0.414564351757732 no 1369 0.402948048074179 1953 742806
SGTC_1568 digitonin 820 nM 0.24545280258802 0.414666579114026 no 1370 0.403052924283802 2034 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2557 derrustone 83.84 µM 0.244403703852837 0.415062473540322 no 1371 0.403459086743332 1790 629853 An antioxidant.
SGTC_3208 9114115 49.47 µM 0.244139873116825 0.415162047939158 no 1372 0.403561246196274 1741 650895
SGTC_2198 6589944 200 µM 0.243910347175798 0.415248679533064 no 1373 0.403650127640419 1933 5290268
SGTC_956 1185-0240 191 µM 0.243622759630859 0.415357231542868 no 1374 0.40376149983709 1879 1416193
SGTC_2439 5492030 7.2 µM 0.243357232526431 0.415457462415699 no 1375 0.403864335756094 1988 5722370
SGTC_2146 5545642 200 µM 0.24169335835756 0.416085664760762 no 1376 0.404508888140113 1968 825326
SGTC_2623 humulene 100 µM 0.238791266882929 0.417181873325776 no 1377 0.405633721192699 1831 6187145 An anti-inflammatory.
SGTC_1879 gemcitabine 100 µM 0.234571987434323 0.41877677084678 no 1378 0.407270476869975 1909 60750 A nucleoside analog which inhibits DNA replication.
SGTC_693 4161-2696 114 µM 0.232351131557987 0.419616797926984 no 1379 0.408132650823947 1975 805759
SGTC_1285 0929-0069 65.5 µM 0.230093875429316 0.420470968712093 no 1380 0.409009411964051 1908 1206237
SGTC_1421 4029-0249 71.4 µM 0.229516872135332 0.420689373448247 no 1381 0.409233604265919 2031 2894095
SGTC_119 0121-0043 24.815 µM 0.229176062385954 0.420818386721902 no 1382 0.409366038471847 2006 1092378
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.227831970462414 0.421327274486079 no 1383 0.409888435697369 1912 1377
SGTC_1147 3809-1045 12.3 µM 0.227813378043537 0.421334314700936 no 1384 0.40989566298486 1878 325925
SGTC_3295 9122362 53.5725 µM 0.227770810407484 0.421350433478513 no 1385 0.409912210088753 1857 4730473
SGTC_775 4577-0580 57.3 µM 0.227397403747035 0.421491834313001 no 1386 0.410057369462287 1962 2006902
SGTC_991 3996-0057 64.7 µM 0.227216774370533 0.421560238292963 no 1387 0.41012759236431 1905 715343
SGTC_2490 carminic acid 95.39 µM 0.226954160830227 0.42165969373217 no 1388 0.410229693217575 1932 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1616 st002734 56.1 µM 0.22694358374499 0.421663699527763 no 1389 0.41023380558329 1925 4026101
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.226729682489378 0.421744710797103 no 1390 0.410316972407604 1883 6708760
SGTC_1698 5-fluorocytosine 1.055 µM 0.226713093607895 0.421750993677267 no 1391 0.410323422489667 2030 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1512 0259-0544 12.2 µM 0.226349390099852 0.421888747904436 no 1392 0.410464843631072 1928 18476
SGTC_2359 9039622 200 µM 0.225759370614184 0.422112240578709 no 1393 0.410694289405482 1952 6463596
SGTC_2200 6600604 21.907 µM 0.22574213214898 0.422118770690857 no 1394 0.410700993530437 1910 2904777
SGTC_1401 3807-4679 7.6 µM 0.224972780223462 0.422410231076735 no 1395 0.411000224861621 1895 3291456
SGTC_1889 st059080 5.18 µM 0.224516153100586 0.422583239266729 no 1396 0.411177849678427 2064 176925 Isolated from Daphnopsis sellowiana.
SGTC_1318 1280-3875 124 µM 0.224005589127679 0.422776700889182 no 1397 0.411376477122808 1941 373245
SGTC_2249 haloperidol 116.36 µM 0.223950988559309 0.422797391103166 no 1398 0.411397720020689 1918 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_201 4262-0159 12.803 µM 0.22321578170362 0.423076009418934 no 1399 0.411683784882963 2027 1341029
SGTC_2022 5136654 200 µM 0.223214964958181 0.423076318959013 no 1400 0.411684102700165 1912 1713771
SGTC_1154 4088-0362 150 µM 0.223088207906488 0.423124359457174 no 1401 0.411733427915941 1897 6618304
SGTC_2952 9073731 13.78 µM 0.222437857532764 0.423370858033553 no 1402 0.411986521930774 1871 16457353
SGTC_2961 9083290 32.55 µM 0.222370924806146 0.423396228865498 no 1403 0.412012571927556 1973 17741490
SGTC_549 1661-1316 519 µM 0.222151628336801 0.423479355357503 no 1404 0.41209792410689 2019 2857282
SGTC_1391 3442-0225 151 µM 0.221293702653549 0.423804593251268 no 1405 0.412431876499899 1908 5227075
SGTC_3196 9111891 49.47 µM 0.220013543981302 0.424289995274192 no 1406 0.412930303282414 1996 18891510
SGTC_1627 st003713 25.6 µM 0.218614856113143 0.424820471691518 no 1407 0.4134750396068 1883 16195070 YER133W GLC7
SGTC_534 k292-0788 63.4 µM 0.218463602079467 0.424877845560218 no 1408 0.413533957364492 2070 4146317
SGTC_1557 sumaresinolic acid 42.3 µM 0.218238470246116 0.424963245794794 no 1409 0.413621656236198 1880 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2000 st075254 36.4 µM 0.218174279400455 0.424987596232008 no 1410 0.413646662217922 1910 17234175
SGTC_2838 9002687 71.43 µM 0.216682399767791 0.425553612837599 no 1411 0.414227932551835 1834 6457060
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.21573156599315 0.425914437703808 no 1412 0.414598497214774 1905 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_928 2764-0428 58.7 µM 0.215310019790159 0.426074427017295 no 1413 0.414762809080238 1945 662578
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.214149491380401 0.426514944829276 no 1414 0.415215241175126 1886 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1084 voriconazole 435 nM 0.213745762222855 0.426668215411538 no 1415 0.41537266141521 2049 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1654 st012436 41.8 µM 0.213105263577208 0.426911395196029 no 1416 0.415622429601415 2034 4323132
SGTC_1514 1189-1591 158 µM 0.211520811167934 0.42751308753577 no 1417 0.416240447301213 2011 767698 YMR146C TIF34
SGTC_2033 5192550 145 µM 0.209941819872145 0.428112873803975 no 1418 0.416856540978576 1889 182073
SGTC_3048 9093155 49.47 µM 0.209835223731383 0.428153370783076 no 1419 0.416898140230256 2054 25236002
SGTC_2492 derrusnin 100 µM 0.209014621959657 0.428465151208186 no 1420 0.41721841202052 1928 1715307 Part of coumarin class of compounds.
SGTC_99 0109-0120 622.8 µM 0.20879752547004 0.428547642587132 no 1421 0.417303151575909 2018 759414
SGTC_1079 idarubicin 2.36 µM 0.208663340474671 0.428598631178814 no 1422 0.417355530100935 2051 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_448 monastrol 171 µM 0.208382508441494 0.428705347636164 no 1423 0.417465156400202 2012 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_72 0744-0168 198.391 µM 0.205308636897015 0.429873761068603 no 1424 0.41866549826191 1944 677577
SGTC_765 1319-0117 244 µM 0.205247106280203 0.429897155860616 no 1425 0.418689533640423 1940 3487746 YGL099W LSG1
SGTC_2822 7994718 71.43 µM 0.204138936969478 0.430318539226238 no 1426 0.419122463818899 2007 1018011
SGTC_29 0299-0004 12.984 µM 0.203911563433404 0.430405008249208 no 1427 0.419211304308656 2032 16871 A napthoquinone isolated from Swertia calycina.
SGTC_829 1635-0120 117 µM 0.20380913670058 0.430443961715947 no 1428 0.419251326324007 2041 285054
SGTC_1715 st032160 10.2275 µM 0.203780400947014 0.430454890207416 no 1429 0.419262554624592 2020 5289825
SGTC_1452 4194-0072 190 µM 0.202761007943139 0.430842609855931 no 1430 0.419660917991338 2061 1343545
SGTC_2852 9023854 51.95 µM 0.202624666712852 0.430894471438716 no 1431 0.419714204333966 1991 19798528
SGTC_1022 4477-0945 21.3 µM 0.200963064682085 0.431526608403628 no 1432 0.420363727477979 1877 4648966
SGTC_2068 5226020 147 µM 0.200953095835433 0.431530401465113 no 1433 0.420367624973947 1913 1810509
SGTC_1625 st003711 30.1 µM 0.200030523314843 0.431881459756986 no 1434 0.420728354678066 2011 24207034 YER133W GLC7
SGTC_3016 9080866 49.47 µM 0.198691348051556 0.432391139830043 no 1435 0.421252096172838 1970 17066299
SGTC_135 0933-0004 26.348 µM 0.198198864474123 0.432578603735131 no 1436 0.421444737941206 1892 21230617 YGL099W LSG1
SGTC_700 3453-2283 142 µM 0.198175223755085 0.432587602958431 no 1437 0.421453985809061 2014 565664
SGTC_1733 st037357 54.9 µM 0.197676900301495 0.432777305996987 no 1438 0.421648931978292 1821 1272339 YGL099W LSG1
SGTC_1813 st051246 8.6015 µM 0.197432320168233 0.432870419054866 no 1439 0.421744619753642 2059 5291959
SGTC_1346 1488-2224 62.4 µM 0.196708480214079 0.43314601089202 no 1440 0.422027836752617 2072 3722427
SGTC_968 1309-0633 340 µM 0.196664580612749 0.433162726092213 no 1441 0.422045014656668 2076 3761976
SGTC_2775 cyproheptadine 69.59 µM 0.195489925223859 0.43361003186791 no 1442 0.422504712018759 2077 2913 A selective serotonin reuptake inhibitor.
SGTC_885 0865-0106 16.8 µM 0.19323590038561 0.43446859647019 no 1443 0.423387112052638 1916 2793380
SGTC_2144 5628481 200 µM 0.193218718684714 0.434475142222349 no 1444 0.423393839783951 1949 2818399
SGTC_2260 7964312 200 µM 0.193172302365885 0.434492825644035 no 1445 0.423412014843692 2071 231951
SGTC_1775 st081588 35.1725 µM 0.191560271844158 0.435107048818081 no 1446 0.424043332293005 2047 1426443 YGL099W LSG1
SGTC_1637 st007924 17.4 µM 0.189150032282455 0.436025700929345 no 1447 0.424987614544135 1971 683336
SGTC_1786 berberine 21.6 µM 0.188951089310879 0.436101542652073 no 1448 0.425065575615465 1991 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_406 estrone 100 µM 0.18867699098416 0.436206039205419 no 1449 0.425172993102626 2094 5870 A steroid.
SGTC_536 3852-0578 10.6 µM 0.186574656769204 0.437007675315778 no 1450 0.425997069385211 2076 2869208
SGTC_139 0099-0334 718.624 µM 0.18617703425856 0.437159321011996 no 1451 0.426152966547228 2127 97690
SGTC_703 3875-0075 71.8 µM 0.185796700588786 0.437304381711633 no 1452 0.42630209601641 1996 2850814
SGTC_1996 st072960 66.8 µM 0.185685884388066 0.437346649016067 no 1453 0.426345549217934 2098 1719405
SGTC_1966 st070145 16.1 µM 0.185374355915332 0.437465475442469 no 1454 0.426467710418593 1994 3748532
SGTC_2999 9069765 71.4286 µM 0.178402379464729 0.440126255125868 no 1455 0.429203490369542 2034 2097066
SGTC_757 1066-0008 322 µM 0.177708379745553 0.440391262712867 no 1456 0.429476001959219 2057 6842497
SGTC_879 0831-1030 162 µM 0.177239263755123 0.44057041235139 no 1457 0.429660227916229 1931 1549252
SGTC_3078 9116413 49.47 µM 0.176892547329173 0.440702826918735 no 1458 0.429796396339242 2056 17177322
SGTC_3060 1327-0027 12.5 µM 0.175399571806008 0.441273085182705 no 1459 0.430382838510006 2103 16000455 YPR107C YTH1
SGTC_2366 9070441 60.58 µM 0.17392076482426 0.441838051671995 no 1460 0.430963866679128 1991 6837235
SGTC_2433 5607874 27.82 µM 0.173779329640136 0.441892092081876 no 1461 0.431019444882346 2001 2252428
SGTC_2836 9010338 19.48 µM 0.173392497652117 0.442039900706947 no 1462 0.431171460898589 1862 2994051
SGTC_2459 5811157 9.22 µM 0.173021822149567 0.442181543505726 no 1463 0.43131713735706 2126 2870684 YBR192W RIM2
SGTC_2864 9034755 47.6 µM 0.172854867167225 0.442245342883447 no 1464 0.431382754162223 2137 4930451
SGTC_1461 k072-0203 53.8 µM 0.172759629898532 0.442281737068491 no 1465 0.431420185252013 2114 5418714
SGTC_1573 oleylamine 1.06 µM 0.171663671849707 0.442700583935989 no 1466 0.431850973722563 1975 5356789 An amine of the fatty acid oleic acid.
SGTC_1911 st060208 74.3 µM 0.170994834406979 0.442956227837417 no 1467 0.432113913661584 2065 688783
SGTC_1336 1486-0901 104 µM 0.170002165933232 0.443335690599492 no 1468 0.432504216638987 2023 5006114
SGTC_2893 9048488 25.97 µM 0.168953922104817 0.443736454304594 no 1469 0.432916442546031 1951 6467338
SGTC_2449 5812982 45.77 µM 0.168046529125514 0.444083414515075 no 1470 0.43327333728893 2087 776185
SGTC_827 3253-0474 693 µM 0.166730194679635 0.444586817952497 no 1471 0.433791173078046 2118 5402065
SGTC_2883 9059145 45.46 µM 0.165570926900131 0.445030228723821 no 1472 0.43424731421302 2011 16476510
SGTC_482 fipronil 114 µM 0.163440097692682 0.445845433091208 no 1473 0.435085966961298 2125 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2452 5863136 48.41 µM 0.163219297335864 0.445929919187025 no 1474 0.435172886434982 2073 2184096
SGTC_1323 1348-1351 11.2 µM 0.163112039847077 0.445970960615939 no 1475 0.435215110162628 1967 6989654
SGTC_1842 st055362 61.2 µM 0.162038524790396 0.446381766475653 no 1476 0.435637758171303 2024 676032
SGTC_522 1273-0010 11.6 µM 0.161639511465698 0.44653447303205 no 1477 0.435794870393018 2045 5705015
SGTC_2076 5212012 200 µM 0.161418299841823 0.446619136443028 no 1478 0.435881977239757 2102 604802
SGTC_2315 7733312 200 µM 0.160371062215197 0.447019974335243 no 1479 0.436294391783545 1997 726316
SGTC_2555 cholic acid 100 µM 0.158550110803397 0.447717085510245 no 1480 0.43701166863443 2032 6708657 Influences liver metabolism.
SGTC_307 1501-1223 22.3 µM 0.157377623672315 0.448166032025878 no 1481 0.437473623708419 2050 2830329
SGTC_1235 benzylparaben 21.5 µM 0.156930386494235 0.448337297121591 no 1482 0.437649855798795 2068 7180
SGTC_1329 1447-1697 50.6 µM 0.15462325943996 0.449220941092142 no 1483 0.438559166072493 2041 2840515
SGTC_1868 st057644 42.7 µM 0.154608950805323 0.449226422178463 no 1484 0.438564806566054 2105 688665
SGTC_1088 bifonazole 369 nM 0.153425131898828 0.449679931027299 no 1485 0.439031513559825 2118 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_138 0850-0259 40.9225 µM 0.153360506295695 0.449704690328738 no 1486 0.439056993906943 2141 6813004
SGTC_2325 6158266 200 µM 0.152990554485571 0.449846429690618 no 1487 0.439202862014995 2020 3623240
SGTC_378 3970-0959 8.33 µM 0.15276437450874 0.449933089009865 no 1488 0.439292046469286 2055 6615653
SGTC_1905 st060207 84.5 µM 0.150799818048379 0.450685895442644 no 1489 0.44006681490046 2002 1948547
SGTC_1484 3473-2379 286 µM 0.150734340978084 0.450710988939764 no 1490 0.440092641271933 2146 671917
SGTC_445 e6 berbamine 66 µM 0.150429300447886 0.450827895569279 no 1491 0.440212962934059 2044 6610268 A calcium/calmodulin antagonist.
SGTC_2326 6164455 177.58 µM 0.14981834084735 0.451062058346774 no 1492 0.440453969386701 2036 2888790
SGTC_261 5-fluorouridine 15.376 µM 0.1496876424922 0.451112153381945 no 1493 0.440505529095098 2130 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2519 cryptotanshinone 88.04 µM 0.149068506908473 0.451349470829265 no 1494 0.440749788020418 2115 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_3014 9081533 49.47 µM 0.148606788440126 0.451526460914065 no 1495 0.440931958047352 2144 21367265
SGTC_39 0986-0283 58.349 µM 0.148191950000832 0.451685488742774 no 1496 0.441095642321536 2143 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_489 paxilline 115 µM 0.147657910105319 0.45189022372153 no 1497 0.441306375148786 2016 105008 A toxic potassium channel blocker.
SGTC_1426 4048-4480 71.7 µM 0.147351888734739 0.452007548964296 no 1498 0.441427139067327 2129 14224343
SGTC_1316 1272-0050 65.9 µM 0.147201609313858 0.452065165983979 no 1499 0.441486445193723 2095 7340392
SGTC_3009 9080819 71.4286 µM 0.147158778618903 0.452081587425917 no 1500 0.441503348098363 2019 17027216
SGTC_1365 1672-3266 55.4 µM 0.145488256331562 0.452722135335776 no 1501 0.442162693594556 2145 6415873
SGTC_1355 1499-0035 1.68 µM 0.145447559579086 0.452737741709996 no 1502 0.442178758374716 2037 1548538
SGTC_833 3852-0053 558 µM 0.144291767283767 0.453180994862466 no 1503 0.442635039517339 2085 3123681
SGTC_3148 9097893 49.47 µM 0.143887255353931 0.453336141380222 no 1504 0.442794749856671 2023 17174100
SGTC_2464 5717415 7.67 µM 0.143873541555469 0.45334140129586 no 1505 0.442800164533485 1979 5285744
SGTC_1163 k060-0048 49.9 µM 0.143761035518728 0.453384553198705 no 1506 0.442844586169135 2128 6809982
SGTC_686 1319-0111 510 µM 0.14242443781485 0.453897249743737 no 1507 0.443372380279639 2146 4562600
SGTC_2355 9061122 103.12 µM 0.139642107854824 0.454964750499501 no 1508 0.444471384648181 2139 5302957
SGTC_3313 9133968 57.047 µM 0.138343085243049 0.455463260339097 no 1509 0.444984637878883 2147 1494643
SGTC_1860 st056228 74.6 µM 0.137538151654826 0.455772194988776 no 1510 0.445302719305364 2035 688679
SGTC_2423 st077119 87.2 µM 0.136620214468454 0.45612453320747 no 1511 0.445665498744887 2161 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3237 9133362 49.47 µM 0.136552528475714 0.456150514962432 no 1512 0.445692250840335 2170 43845137
SGTC_2029 5175081 200 µM 0.132681196099819 0.457636862337307 no 1513 0.447222757353241 2163 1380876
SGTC_3027 9089541 49.47 µM 0.131758581952168 0.457991176194453 no 1514 0.447587623836719 2078 9943819
SGTC_1152 3909-8331 15.9 µM 0.131662689820648 0.45802800381364 no 1515 0.447625548875596 2033 16001939
SGTC_508 roscovitine 141 µM 0.131218180899826 0.45819872330701 no 1516 0.447801357015944 2124 160355 A CDKinase inhibitor.
SGTC_2344 7990960 76.95 µM 0.131048700540662 0.458263816498828 no 1517 0.447868391053992 2068 140813
SGTC_2153 5569715 200 µM 0.13016050625425 0.458604968103034 no 1518 0.448219720073998 2188 2054701
SGTC_2922 7999257 32.47 µM 0.130051119328136 0.458646985264698 no 1519 0.448262991351707 2170 2988377
SGTC_2936 9038235 15.59 µM 0.12879038615089 0.459131285049695 no 1520 0.448761756456715 2160 4749415
SGTC_2687 chenodiol 100 µM 0.127301064395072 0.45970347326644 no 1521 0.449351058948301 2102 5702181 A cholesterol synthesis inhibitor.
SGTC_1752 st044819 83.042 µM 0.127184824183906 0.459748135564387 no 1522 0.449397058190329 2074 441209 YML126C ERG13
SGTC_2572 astragaloside iv 100 µM 0.126549493495879 0.459992253927121 no 1523 0.44964848688877 2061 45006101 An anti-inflammatory agent.
SGTC_590 k048-0076 22.4 µM 0.12481709847135 0.460657982756261 no 1524 0.450334175315151 2195 6832814
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.123282990581894 0.46124760547368 no 1525 0.450941504813721 2192 5355888
SGTC_2274 7947094 46.08 µM 0.121591562564716 0.461897791687895 no 1526 0.451611248001933 2219 2971028
SGTC_2873 9040596 71.43 µM 0.121432051988408 0.461959112956391 no 1527 0.451674415451834 2023 6463863
SGTC_2265 7929201 200 µM 0.121319059823987 0.46200255151892 no 1528 0.451719161983113 2209 1265108
SGTC_782 0083-0095 30.5 µM 0.119515512620768 0.462695965894915 no 1529 0.452433475414062 2226 3591729 An indicator and reagent.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.119399125479645 0.462740717471613 no 1530 0.452479577052874 2179 94937 An inhibitor of serotonin biosynthesis.
SGTC_862 0452-0056 10.2 µM 0.117466534175419 0.463483879300514 no 1531 0.453245181134805 2181 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2403 6032726 181.2 µM 0.117014808207663 0.463657605216512 no 1532 0.453424159422533 2115 2881040
SGTC_3307 9126885 69.2785 µM 0.116985817790627 0.463668754661474 no 1533 0.453435646035397 2073 24824909
SGTC_1623 st003709 20.3 µM 0.116951957726188 0.463681776963697 no 1534 0.453449062154285 2054 16192618
SGTC_3306 9127676 59.7925 µM 0.116669958036438 0.463790233234657 no 1535 0.453560798834574 2057 41905287
SGTC_1252 0493-0875 34.8 µM 0.116648082609446 0.46379864657364 no 1536 0.453569466684371 2141 3960963
SGTC_2479 5617353 43.85 µM 0.116407439405395 0.463891199565132 no 1537 0.453664819843197 2156 2731746
SGTC_713 1488-1073 324 µM 0.11640601827272 0.463891746148107 no 1538 0.453665382964856 2214 3312542
SGTC_1887 st057648 70.8 µM 0.115808141856625 0.464121701907431 no 1539 0.453902298834006 2192 688672
SGTC_3166 9102297 49.47 µM 0.109560867998696 0.466525236492266 no 1540 0.456378823290186 2093 25237072
SGTC_428 3448-4153 16.5 µM 0.107092845505302 0.46747510847646 no 1541 0.457357661492968 2034 3834874
SGTC_620 0109-0052 432 µM 0.106955057382659 0.467528144733497 no 1542 0.457412317086706 2219 493037
SGTC_1108 betulinic acid 729.144 nM 0.106593463696316 0.467667329103763 no 1543 0.457555752127897 2142 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1202 1988-0068 29.6 µM 0.106284905411697 0.467786102253458 no 1544 0.457678153743265 2062 2850480
SGTC_1319 1306-0155 43.7 µM 0.105346196310583 0.468147456557097 no 1545 0.458050553763533 2173 3122360
SGTC_2595 hexamethylquercetagetin 100 µM 0.104372416431906 0.468522339022421 no 1546 0.458436905802355 2143 386331
SGTC_677 0929-0063 136 µM 0.103467063794414 0.468870903648167 no 1547 0.458796144225478 2226 1539583
SGTC_2624 nerol 100 µM 0.102276247302073 0.469329409366738 no 1548 0.459268704166608 2192 637566 A natural product oil.
SGTC_2157 5649910 96.377 µM 0.100858606641127 0.469875303256445 no 1549 0.459831351302728 2136 2858091
SGTC_3104 9120930 49.47 µM 0.100653547175386 0.469954270650901 no 1550 0.459912744002483 2135 17014836
SGTC_46 0329-0187a 2.197 µM 0.0995981455074216 0.470360719281421 no 1551 0.460331683088399 2155 46494817
SGTC_1558 st069300 45.6 µM 0.09957376492201 0.470370108922078 no 1552 0.460341361423775 2238 24208000
SGTC_1629 st005085 44.9 µM 0.0980417817396317 0.47096015102537 no 1553 0.460949558066132 2148 24207091
SGTC_3247 9135149 49.47 µM 0.0979657573834535 0.470989433416744 no 1554 0.460979742092678 2236 8934436 YOR116C RPO31
SGTC_2874 9043904 71.43 µM 0.0977670179037596 0.471065982878242 no 1555 0.461058648889588 2099 4463428
SGTC_627 1391-0720 175 µM 0.0969745362648322 0.471371237526249 no 1556 0.46137330811958 2157 997839
SGTC_2832 7992762 51.95 µM 0.0965609028907786 0.471530570950615 no 1557 0.461537553162286 2018 2985177
SGTC_3340 9146634 11.102 µM 0.0964751445929713 0.471563606001376 no 1558 0.461571606786019 2133 4907387
SGTC_563 tetrahydrosecaminediol 614 µM 0.0956066164432659 0.471898183696617 no 1559 0.461916505057167 2239 334274 A psychoactive constituent of the cannabis plant.
SGTC_1085 doxorubicin 7.67 µM 0.0951136978043509 0.472088076513775 no 1560 0.462112259064192 2250 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2676 harmalol 100 µM 0.0947193922174352 0.472239984040451 no 1561 0.462268857233791 2219 5459187 A monoamine oxidase inhibitor
SGTC_1534 6-azauridine 81.6 µM 0.0936700517986402 0.472644265507453 no 1562 0.462685630426597 2232 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3296 9122258 64.045 µM 0.0936635787439998 0.472646759481958 no 1563 0.462688201498389 2159 4730474
SGTC_1820 st053765 18.6 µM 0.0923873495861886 0.473138492975828 no 1564 0.463195145004486 2137 3690829
SGTC_1793 st048256 72.231 µM 0.0908785849173236 0.473719875586218 no 1565 0.4637945332638 2252 672022
SGTC_1337 1486-1011 40.3 µM 0.0899373603566825 0.474082592517037 no 1566 0.464168496083897 2263 X1337
SGTC_826 1683-5028 118 µM 0.0890914492672358 0.474408597117946 no 1567 0.464504616434366 2163 722377
SGTC_2210 7115885 190.385 µM 0.0884574111778774 0.474652959500446 no 1568 0.4647565662771 2224 2927039
SGTC_1614 st002383 48.6 µM 0.0879972629369982 0.47483030958696 no 1569 0.46493942578231 2278 1947235
SGTC_2038 4100038 30.985 µM 0.0874644460470341 0.475035673813877 no 1570 0.465151172519102 2176 3596803
SGTC_3252 9135871 49.47 µM 0.0868448805848532 0.475274481979658 no 1571 0.465397406407015 2222 17682838
SGTC_3008 9078912 71.4286 µM 0.0865644590814861 0.475382571860906 no 1572 0.465508858679976 2196 16648731
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.0864931527726511 0.475410057526131 no 1573 0.465537199485457 2163 803109
SGTC_2683 piperine 63.03 µM 0.0863023633877712 0.475483599604694 no 1574 0.465613029888035 2194 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.0862594910754748 0.475500125371604 no 1575 0.465630069921479 2179 2724 A muscle relaxant with antifungal properties.
SGTC_1773 st048542 73.5835 µM 0.0856417342007019 0.475738253561317 no 1576 0.465875610609947 2135 3237138
SGTC_2982 9019404 25.97 µM 0.0855676497786405 0.475766811640657 no 1577 0.465905057922947 2084 22333232
SGTC_2269 7935389 174.42 µM 0.0850364218891782 0.47597159312239 no 1578 0.466116217542024 2256 97605
SGTC_2006 4011487 200 µM 0.0842452345995248 0.476276597340272 no 1579 0.466430726991442 2238 45595294
SGTC_2085 5307070 144.047 µM 0.083943878364085 0.47639277441227 no 1580 0.466550526380648 2189 2840351
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.0833558433908763 0.476619475943468 no 1581 0.46678429906931 2241 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1005 4092-0690 4.4 µM 0.0832933821420413 0.47664355669307 no 1582 0.466809131148099 2176 1529343
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.0832046286735276 0.476677774055892 no 1583 0.466844416177492 2184 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_203 k066-0004 30.888 µM 0.0825206935342153 0.476941459154513 no 1584 0.467116331696099 2280 6795412
SGTC_1836 st055642 81 µM 0.0824527360718759 0.476967660101902 no 1585 0.467143350725034 2206 8571
SGTC_645 0845-0943 5.41 µM 0.0824091409281751 0.47698446822849 no 1586 0.467160683683419 2171 1885106
SGTC_1925 st057770 10.1 µM 0.0784871598547379 0.478496753650984 no 1587 0.4687202718328 2062 5989122
SGTC_55 0767-0285 6.563 µM 0.0783780691477833 0.478538822706884 no 1588 0.468763659070639 2265 3116166
SGTC_1429 4049-0205 9.46 µM 0.0773396530903288 0.478939282865504 no 1589 0.469176673376187 2251 22774478
SGTC_1575 cyproterone acetate 48 µM 0.0763301733025791 0.479328604275914 no 1590 0.469578210518569 2179 9880 An androgen receptor antagonist and liver toxin.
SGTC_972 1319-0219 195 µM 0.0748813770125934 0.4798873892251 no 1591 0.470154546971038 2178 23903702
SGTC_252 miconazole 1.30953 nM 0.0742343704200793 0.480136945454059 no 1592 0.47041194882428 2286 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1718 roemerine 11.9335 µM 0.0741214253439213 0.480180510180943 no 1593 0.470456883596628 2269 235224 An aporphine alkaloid with mutagenic activity.
SGTC_399 oxolinic acid 75 µM 0.0740470286953358 0.480209206290568 no 1594 0.470486482228069 2145 4628 A DNA gyrase inhibitor.
SGTC_905 2-aminofluorene 215 µM 0.0736675663513381 0.480355573253464 no 1595 0.470637453471412 2279 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1588 farnesol 29.9 µM 0.0735488920540332 0.480401349081837 no 1596 0.470684669580271 2271 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1017 4239-0030 168 µM 0.0729403382582838 0.480636088491324 no 1597 0.470926797064138 2102 1149593
SGTC_3239 9133757 49.47 µM 0.0728674276736636 0.480664212977269 no 1598 0.470955806982984 2262 17036923
SGTC_481 bay k-8644 50 µM 0.0715945957146426 0.481155209810051 no 1599 0.471462270517493 2153 2303 A calcium channel antagonist.
SGTC_2869 9037858 32.47 µM 0.0712104181079186 0.481303412547467 no 1600 0.471615145008549 2296 27187042
SGTC_1747 st037496 66.6 µM 0.0706299062012203 0.481527359318433 no 1601 0.471846154068463 2242 723305
SGTC_1058 3448-5425 97.3 µM 0.0702222104625141 0.481684641483529 no 1602 0.472008398283902 2271 7279705
SGTC_733 4069-0007 56.1 µM 0.0700374925135815 0.48175590350414 no 1603 0.472081909090846 2287 5717425 YNL287W SEC21
SGTC_1830 st055982 50.3 µM 0.0682357239698364 0.482451034926288 no 1604 0.472798994807658 2286 455313 An antimicrobial agent.
SGTC_2013 4024628 200 µM 0.0680971340758578 0.482504505845385 no 1605 0.47285415586956 2225 5230760
SGTC_616 4092-0450 108 µM 0.0679456481673834 0.482562952680218 no 1606 0.472914450353239 2221 787165
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.0678075750292298 0.482616224878522 no 1607 0.472969406821199 2269 688669
SGTC_153 4077-0274 519.67 µM 0.0676847839632975 0.482663601117718 no 1608 0.473018281084928 2287 3121976
SGTC_770 0389-1121 67.2 µM 0.0667795480584449 0.483012874044802 no 1609 0.473378602671528 2267 6753108
SGTC_2776 terbinafine 19.92 µM 0.065803536802169 0.483389469273648 no 1610 0.473767120190393 2288 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2122 5258151 111.688 µM 0.0647603007863668 0.483792019641678 no 1611 0.47418242522447 2236 2173356
SGTC_855 0428-0020 25 µM 0.0643273758293565 0.483959075976916 no 1612 0.474354777915919 2179 6812414
SGTC_634 1611-4317 11.2 µM 0.0630254292658291 0.484461485719173 no 1613 0.47487312747255 2306 2843522
SGTC_2206 7254556 146.969 µM 0.0629841604242981 0.484477411410194 no 1614 0.474889558713152 2285 4398905
SGTC_3202 9113761 49.47 µM 0.0629343644143628 0.484496627777777 no 1615 0.474909385113319 2270 4798415
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.0628323096127965 0.484536011017189 no 1616 0.474950018670168 2197 688803
SGTC_2223 6903751 107.57 µM 0.0624333860706644 0.484689958195273 no 1617 0.47510885428496 2268 5598863
SGTC_331 k048-0133 24.5 µM 0.0620892313733044 0.484822771555985 no 1618 0.475245886286236 2292 6813582
SGTC_2978 9011784 42.97 µM 0.0611500121466099 0.485185235868254 no 1619 0.475619869854567 2296 2994934
SGTC_385 1494-0393 12.4 µM 0.0593256414999924 0.485889333310267 no 1620 0.476346369057663 2241 3090647
SGTC_1502 4534-4282 27.7 µM 0.0586873630016256 0.486135680956497 no 1621 0.476600562426532 2215 3278949
SGTC_56 0957-0365 83.25 µM 0.0582696009798613 0.486296921736635 no 1622 0.476766940631091 2291 6752360
SGTC_1243 0416-0003 5.65 µM 0.0579725810972508 0.486411561854641 no 1623 0.47688523444924 2238 2141977
SGTC_764 1951-2361 146 µM 0.0571101028926728 0.486744457021859 no 1624 0.477228744307746 2237 5438930
SGTC_2517 totarol 10 µM 0.0570580503337332 0.486764548314756 no 1625 0.477249476467952 2212 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2906 7926292 26.41 µM 0.0566726979826565 0.486913287998767 no 1626 0.477402961452021 2225 2966319
SGTC_2155 5570423 76 µM 0.0553932561734519 0.487407144483396 no 1627 0.477912584192168 2230 797402
SGTC_1057 3448-5381 134 µM 0.054858589282451 0.487613528302449 no 1628 0.478125561567416 2298 5497911
SGTC_662 k832-1615 104 µM 0.0543340977785983 0.4878159875998 no 1629 0.478334491783974 2258 5878478
SGTC_206 4546-0025 72.014 µM 0.0538459240048725 0.488004430689584 no 1630 0.478528960251344 2241 6620745 YIL048W NEO1
SGTC_2698 st077697 67.5 µM 0.0526324790435637 0.488472851874521 no 1631 0.479012369145922 2248 3154499
SGTC_45 0kpi-0036 14.9 µM 0.0520842196666242 0.488684499448699 no 1632 0.479230793390238 2279 2795021
SGTC_1122 capsaicin 818.572 nM 0.0519798677375338 0.488724783358991 no 1633 0.479272367471215 2255 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_638 3970-0837 4.09 µM 0.0512782913614047 0.488995622140351 no 1634 0.479551883163313 2287 4118451 YLR208W SEC13
SGTC_2809 7964133 12.99 µM 0.0502013187520291 0.489411389911139 no 1635 0.479980980334345 2260 1253665
SGTC_3075 9116269 49.47 µM 0.0492188217383972 0.48979069520738 no 1636 0.480372455932863 2265 17015205 YNL244C SUI1
SGTC_2701 st077767 14.721 µM 0.0491105319400985 0.489832502413511 no 1637 0.480415605131018 2287 5721188
SGTC_735 3076-0345 636 µM 0.0482736447756301 0.490155601347767 no 1638 0.480749079240589 2306 2888990
SGTC_676 falcarinol 140 µM 0.0481098951272767 0.490218821309868 no 1639 0.480814330083833 2325 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2336 9001819 198.65 µM 0.0480245168536095 0.490251783989517 no 1640 0.480848351761506 2287 2989602
SGTC_893 0958-0369 48.9 µM 0.0479569742182868 0.490277860767404 no 1641 0.480875266362942 2332 6819948
SGTC_1904 st060225 78 µM 0.0474741275940659 0.490464278804176 no 1642 0.481067675134081 2319 66595
SGTC_1067 clotrimazole 1.36 µM 0.046491507487459 0.490843656409896 no 1643 0.481459251406035 2265 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1238 0333-0287 48.8 µM 0.0455439732533158 0.491209495638228 no 1644 0.481836862827213 2314 7226
SGTC_3229 9132204 49.47 µM 0.0451138422385573 0.49137556998431 no 1645 0.482008284072834 2274 17682924
SGTC_3026 9090633 49.47 µM 0.0447578157009618 0.49151303359273 no 1646 0.482150174783637 2308 25236842
SGTC_1909 st060837 51.5 µM 0.0445436358792923 0.491595729968641 no 1647 0.482235535036695 2264 678937
SGTC_2126 5251174 33.877 µM 0.0443975174058058 0.491652147573992 no 1648 0.482293770261258 2318 790722
SGTC_1137 ixabepilone 100 µM 0.0441669792199699 0.491741160698978 no 1649 0.48238565156063 2336 154225 A novel microtubule stabilizer.
SGTC_2506 ethyl hematommate 54.16 µM 0.0437435003188135 0.491904671253753 no 1650 0.48255443207182 2155 3940691 An allergen.
SGTC_2370 9071495 200 µM 0.0437309176224785 0.491909529612746 no 1651 0.482559447042417 2192 21791103
SGTC_720 r052-1644 49.9 µM 0.0435430802436347 0.491982056453181 no 1652 0.482634312002158 2292 1422863 YOR257W CDC31
SGTC_2067 5224629 34.075 µM 0.0423922255430815 0.492426424480411 no 1653 0.483093012948774 2274 2835000
SGTC_32 0928-0142 34.1 µM 0.0419251919082008 0.492606758223877 no 1654 0.483279166905885 2343 2244242
SGTC_2665 lovastatin 100 µM 0.0416252911794605 0.492722558436536 no 1655 0.483398705632785 2316 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_557 1315-0110 16.2 µM 0.0415202401175891 0.492763121788963 no 1656 0.483440578742768 2333 6833801
SGTC_505 gw-5074 63.9 µM 0.040892625897067 0.493005463928304 no 1657 0.483690748106777 2306 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_419 nsc-638432 893 µM 0.0402991964589596 0.493234608594078 no 1658 0.483927297196512 2233 368090
SGTC_711 k292-0785 179 µM 0.0377457715651339 0.494220603232759 no 1659 0.484945190774174 2339 4146315
SGTC_2586 curcumin 80 µM 0.0358658982289029 0.494946531581775 no 1660 0.485694643816976 2323 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2017 5132927 60.65 µM 0.0351429936299955 0.4952256916472 no 1661 0.485982859305369 2326 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_681 1642-0006 26.6 µM 0.034951491546722 0.495299643343456 no 1662 0.486059210677106 2346 4446530
SGTC_1241 0364-0022 50.8 µM 0.0345880637686193 0.495439987431899 no 1663 0.486204109769421 2307 4563895
SGTC_2899 9053889 58.44 µM 0.0340135545655682 0.495661845504325 no 1664 0.486433170987733 2357 6470052
SGTC_1184 1269-1718 139 µM 0.0329574478292471 0.496069685423655 no 1665 0.486854260452376 2339 5403821
SGTC_1951 sophoraflavanone G 9.2 µM 0.0318799939410195 0.496485773267257 no 1666 0.48728387652593 2352 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_114 0364-0001 490.298 µM 0.0309629307899213 0.496839924936501 no 1667 0.487649551216502 2253 4003655
SGTC_1738 st035555 74 µM 0.0307968287967832 0.496904070518878 no 1668 0.487715784737769 2325 5331140
SGTC_3123 9126162 49.47 µM 0.0301940855839457 0.497136839694682 no 1669 0.487956132701424 2354 25239884
SGTC_520 3584-0023 682 µM 0.0288276462807458 0.497664538795485 no 1670 0.488501025747751 2211 1340790
SGTC_934 2950-0684 338 µM 0.0272328683501753 0.498280424075179 no 1671 0.489137000134605 2359 1121253
SGTC_2846 9008642 19.48 µM 0.0271600458844777 0.498308547400448 no 1672 0.489166041353013 2287 2992898
SGTC_1213 1315-0166 115 µM 0.026866284010495 0.498421995452022 no 1673 0.489283192633402 2266 768401
SGTC_1563 conessine 56.1 µM 0.0260704192173297 0.498729351507174 no 1674 0.489600585542478 2353 441082 An anti-amoebic, histamine inhibitor.
SGTC_92 0063-0024 660.874 µM 0.0260035285756205 0.498755184127619 no 1675 0.489627262003774 2362 3594437
SGTC_1263 0774-1208 64.8 µM 0.0243923922267402 0.499377393174422 no 1676 0.490269808322694 2358 906585
SGTC_3006 9075424 71.4286 µM 0.0243335775665467 0.499400107002871 no 1677 0.490293265014898 2332 7465181
SGTC_666 0272-0154 136 µM 0.0228908589088352 0.499957275728512 no 1678 0.490868666010305 2339 6870312
SGTC_978 1416-0512 87.4 µM 0.0226696006942458 0.499957275728512 no 1679 0.490956912366608 2344 6814003
SGTC_2455 5377712 9.75 µM 0.0225814769944533 0.499923242905411 no 1680 0.49099205963899 2272 2243908
SGTC_1693 xanthone 101.9 µM 0.0221922064132735 0.499772909045481 no 1681 0.491147317221209 2311 7020 An insecticide.
SGTC_3214 9129694 49.47 µM 0.0219741144212887 0.499688683297104 no 1682 0.491234302125282 2356 17158655
SGTC_2567 aureobasidin a 60 nM 0.0215059040092257 0.499507863448035 no 1683 0.491421046917449 2309 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1840 st055363 71 µM 0.0204487683767912 0.499099604896616 no 1684 0.491842690215731 2317 676033
SGTC_3311 9131146 2.8755 µM 0.0200379471974831 0.498940948797717 no 1685 0.492006550574792 2289 4900406 YPR165W RHO1
SGTC_844 0330-0132 15.3 µM 0.0195123361280649 0.498737961940484 no 1686 0.492216198055033 2362 2828079
SGTC_2627 acetyl isogambogic acid 100 µM 0.0188386856914829 0.498477803930005 no 1687 0.492484896286576 2344 6857789 A caspase activator and apoptosis inducer.
SGTC_43 0570-0105 72.5 µM 0.0184654882309721 0.498333678548902 no 1688 0.492633754635461 2378 1114046 YDL195W SEC31
SGTC_2101 5377231 179.231 µM 0.0179300552624674 0.498126899711232 no 1689 0.492847326116391 2356 2844213
SGTC_2566 crystal violet carbinol 226 nM 0.0175509233035632 0.497980483055539 no 1690 0.492998554084263 2307 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.0142547608666443 0.496707554421686 no 1691 0.494313365779583 2382 2333 A French combination drug.
SGTC_1983 st071813 46.9 µM 0.0138389042834199 0.496546958942217 no 1692 0.494479252185397 2304 11838595
SGTC_1946 st076057 65.1 µM 0.0138188364444229 0.496539209158862 no 1693 0.49448725732937 2387 953009
SGTC_100 0086-0128 49.5915 µM 0.0137756716197017 0.496522539802919 no 1694 0.494504475963992 2374 93297
SGTC_2504 purpurogallin 52.29 µM 0.0135102679292435 0.496420046562039 no 1695 0.494610346863813 2363 5281571 An antioxidant.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.0125175823672485 0.496036694733988 no 1696 0.495006337555023 2386 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1277 0873-0036 22 µM 0.0118962883582418 0.495796767432673 no 1697 0.495254179533726 2383 5965735
SGTC_2968 9090663 33.37 µM 0.0117896085681655 0.495755570671972 no 1698 0.495296735627965 2338 25236811
SGTC_2919 7978188 46.38 µM 0.011058833205851 0.495473366841111 no 1699 0.495588253786932 2383 2980291
SGTC_389 tpck 16.7 µM 0.0109688362760777 0.495438612842471 no 1700 0.495624155189745 2378 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1030 k029-0042 36.7 µM 0.0105450579221002 0.49527496337017 no 1701 0.495793208510376 2316 6080581
SGTC_2697 mebhydrolin 72.4 µM 0.00865854408427847 0.494546462871529 no 1702 0.496545783838769 2385 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1506 4226-2149 212 µM 0.00852364060601476 0.494494368903766 no 1703 0.496599600553922 2344 991114
SGTC_343 4130-2827 29.8 µM 0.00828186370929231 0.49440100521697 no 1704 0.496696052175111 2380 1118244
SGTC_643 k048-0106 28.4 µM 0.007638918341577 0.494152729278906 no 1705 0.496952542135129 2385 6763920
SGTC_453 enantio-paf c16 10 µM 0.00760119863249747 0.494138163731031 no 1706 0.496967589685007 2386 13871343 A lipid and platelet activating factor
SGTC_414 piperonyl butoxide 100 µM 0.00736407911862902 0.494046599693687 no 1707 0.497062184036176 2389 5794 A potent inhibitor of cytochrome P450.
SGTC_1436 4092-1007 8.32 µM 0.00717658240757491 0.493974197794017 no 1708 0.49713698242468 2393 2881121
SGTC_271 rotenone 740 µM 0.00694961100840605 0.493886552999931 no 1709 0.497227528653473 2355 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2487 5918373 44.05 µM 0.00688856425358192 0.493862979902681 no 1710 0.497251882202094 2394 2876279
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.00663254075582566 0.493764117112658 no 1711 0.497354018465748 2390 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1729 st035615 45.989 µM 0.00599056967950607 0.493516223393421 no 1712 0.497610122765387 2317 17385451
SGTC_2813 7971799 71.43 µM 0.00539267813551907 0.493285353001238 no 1713 0.49784864311441 2386 2234054
SGTC_83 0170-0301 39.027 µM 0.00496216290156915 0.493119114840126 no 1714 0.498020391540331 2395 3089716
SGTC_1155 4088-0394 48.2 µM 0.00465602012548727 0.493000902298847 no 1715 0.498142523424771 2396 2326248
SGTC_1408 3909-7976 48.8 µM 0.00439579431606811 0.492900420403436 no 1716 0.498246337439046 2398 24152374
SGTC_2945 9067681 61.76 µM 0.00435385582575619 0.492884226590526 no 1717 0.498263068315899 2399 16456930
SGTC_2350 9023895 38.85 µM 0.00371931915500738 0.49263921282403 no 1718 0.498516209755723 2392 2997209
SGTC_147 4466-0538 29.23 µM 0.0033378227719838 0.492491906883199 no 1719 0.498668403844335 2379 6742687 YHR072W ERG7
SGTC_2444 5485484 36.41 µM 0.00309222289575213 0.492397074753063 no 1720 0.4987663835124 2390 6790631
SGTC_897 1000-0139 31.4 µM 0.00157208938086348 0.491810123722261 no 1721 0.499372827335743 2388 6151020
SGTC_1640 st009078 66.4 µM 0.00112940655619838 0.491639199158355 no 1722 0.499549432068758 2404 690618
SGTC_906 1165-0455 526 µM 0.00107580441896728 0.491618502904581 no 1723 0.499570816214618 2403 3252859
SGTC_392 N-ethylmaleimide 8.33 µM 0.000979233388222228 0.491581216042372 no 1724 0.499609342461491 2401 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3328 9140624 29.0385 µM 0.000490453174924001 0.49139249515272 no 1725 0.49980433749981 2404 4904392
SGTC_622 1348-1566 26.3 µM 0.000485886412106864 0.491390731907994 no 1726 0.499806159374365 2400 7340407
SGTC_1815 st051655 58.2 µM 0 0.491203130259544 no 1727 0.5 2405 5984156
SGTC_3090 9117696 49.47 µM 0 0.491203130259544 no 1728 0.5 2405 7923821
SGTC_2077 5212015 200 µM -0.000675548135578645 0.490942303108946 no 1729 0.49973049530677 2408 780900
SGTC_259 usnic acid 108.925 µM -0.00218228797556407 0.490360569400336 no 1730 0.499129393749562 2412 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1987 st072290 61.9 µM -0.00230551795647788 0.490312992711595 no 1731 0.499080232223761 2421 54697379
SGTC_3282 9108498 15.4605 µM -0.00233008424716879 0.490303508163035 no 1732 0.499070431718057 2418 16459645
SGTC_970 1315-0089 19.5 µM -0.00281971111370569 0.490114474271743 no 1733 0.498875099508863 2415 6811083 YLR033W RSC58
SGTC_2311 7694451 200 µM -0.00299655225882615 0.490046200437245 no 1734 0.498804550397577 2415 2163142
SGTC_1605 st000082 49.1 µM -0.00320710107523235 0.489964913315133 no 1735 0.498720553976859 2429 1114022
SGTC_69 0096-0274 206.684 µM -0.00329710632057731 0.489930164885956 no 1736 0.498684647268924 2432 6741392
SGTC_1217 1183-1422 255 µM -0.00543022040387026 0.489106654018389 no 1737 0.497833666135557 2418 2849664
SGTC_1903 st060211 78.3 µM -0.00729583612116473 0.488386451623459 no 1738 0.497089408321833 2416 688960
SGTC_883 0850-0245 24.6 µM -0.00744597253422382 0.488328494569326 no 1739 0.497029514185946 2463 6823229 YPR165W RHO1
SGTC_2308 7584454 197.62 µM -0.00803052716407352 0.48810284171515 no 1740 0.496796317614284 2423 893577
SGTC_2372 9071633 200 µM -0.00807538145160652 0.488085526983463 no 1741 0.496778423922744 2427 21321366
SGTC_625 k213-0058 121 µM -0.00858782284484236 0.487887715049145 no 1742 0.49657399648234 2416 3655420
SGTC_1348 1493-0373 93.8 µM -0.00882821025102613 0.487794922051144 no 1743 0.496478099418553 2427 3010129
SGTC_2917 7979103 53.79 µM -0.00945500715383642 0.487552972547047 no 1744 0.496228054085129 2421 2980565
SGTC_286 k060-0067 22.9 µM -0.00994606878519159 0.487363421331254 no 1745 0.496032158057235 2424 5985051
SGTC_1962 st076595 64.5 µM -0.0104698027324718 0.487161261653497 no 1746 0.495823229330045 2424 279619
SGTC_2278 7948257 134.34 µM -0.0107871921185612 0.487038751937866 no 1747 0.495696616436727 2430 1247028
SGTC_369 0957-0393 4.5 µM -0.0126224040508244 0.48633039943702 no 1748 0.494964523057135 2432 6997992
SGTC_3325 9138760 55.175 µM -0.013689973894721 0.485918360039026 no 1749 0.494538661186156 2436 43844959
SGTC_3083 9117465 49.47 µM -0.0137068556169164 0.485911844486881 no 1750 0.494531926985261 2471 16420915
SGTC_523 1934-0222 13.7 µM -0.0140273164300537 0.485788162374429 no 1751 0.494404093909726 2440 1361595
SGTC_1371 2421-0008 32.7 µM -0.0141694717027464 0.485733297867906 no 1752 0.494347387796982 2446 2827552
SGTC_1880 MG-132 525 µM -0.015261280749906 0.485311925710569 no 1753 0.493911866184553 2443 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2290 7904846 200 µM -0.0156544956515679 0.485160172569348 no 1754 0.493755014876646 2443 2962154
SGTC_3035 9091303 49.47 µM -0.0165144008076038 0.484828317516844 no 1755 0.493412006735933 2440 25237002
SGTC_353 1988-1175 58.3 µM -0.0169060428550824 0.484677178279722 no 1756 0.493255785977811 2389 2788357
SGTC_97 0535-0701 19.132 µM -0.0171188710156343 0.48459504633037 no 1757 0.493170892112304 2443 2832013 YGL099W LSG1
SGTC_2837 9008476 45.46 µM -0.0175913258898694 0.48441272486736 no 1758 0.492982438272375 2461 2992805
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.0180572738772289 0.48423291761915 no 1759 0.492796581447659 2443 6857784
SGTC_2247 cerulenin 830 nM -0.0199467554107748 0.483503808374033 no 1760 0.492042923564361 2475 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1288 0973-0013 65.5 µM -0.0199806338058394 0.483490735944762 no 1761 0.49202941073321 2468 4315430
SGTC_103 0844-0104 51.839 µM -0.0208129106332335 0.483169596470618 no 1762 0.491697449387186 2468 5375804
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.0221454536553305 0.482655448825242 no 1763 0.491165964290397 2434 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2284 7945075 39.21 µM -0.0222923332639873 0.482598778629513 no 1764 0.491107382266577 2467 1245402
SGTC_2411 st077133 39.94 µM -0.0224510221284295 0.48253755249301 no 1765 0.491044090409703 2547 1403142 YNL221C POP1
SGTC_2334 9017922 200 µM -0.0226455835248101 0.482462486397791 no 1766 0.490966491371865 2467 3163164
SGTC_52 0329-0193 875 nM -0.0230007598889762 0.482325453096548 no 1767 0.490824833403367 2506 3739292
SGTC_2525 harmine 47.85 µM -0.0241697391105572 0.481874455142447 no 1768 0.490358607883775 2479 5280953 A monoamine oxidase inhibitor
SGTC_2182 6325192 200 µM -0.0244495402533917 0.481766509899053 no 1769 0.490247016356015 2451 736248
SGTC_1724 st037281 8.293 µM -0.0249540736421482 0.481571867975489 no 1770 0.490045798056483 2450 574124 YDL195W SEC31
SGTC_3290 9121031 71.43 µM -0.025365170550216 0.481413275784852 no 1771 0.489881846019238 2458 17014854
SGTC_497 capsazepine 133 µM -0.0266277486733682 0.480926219273378 no 1772 0.489378320431089 2458 2733484 A calcium channel blocker.
SGTC_860 0443-0016 25.1 µM -0.0278331812451817 0.480461233985383 no 1773 0.488897600700569 2456 5337942
SGTC_1833 st055984 71 µM -0.0278641195096165 0.480449300162125 no 1774 0.488885262904004 2469 676288
SGTC_2117 5521686 200 µM -0.0287142033686127 0.480121404028223 no 1775 0.488546264194486 2458 803312
SGTC_469 w7 172 µM -0.0287719711200379 0.48009912221523 no 1776 0.488523227713936 2451 45115570 A P450 inhibitor.
SGTC_133 0724-0033 378.92 µM -0.0300442532675692 0.479608401453529 no 1777 0.488015880040865 2445 280309
SGTC_2943 9068529 45.32 µM -0.0302316924823226 0.479536108516009 no 1778 0.487941136565566 2452 3270634
SGTC_2323 6148992 148.28 µM -0.0317784369794046 0.478939574616915 no 1779 0.48732437137393 2494 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_323 4013-0906 34.3 µM -0.0318140159703659 0.478925853395558 no 1780 0.487310184583378 2504 2910086
SGTC_823 0417-1665 178 µM -0.0323724143448268 0.478710507465073 no 1781 0.487087530558898 2500 3429856
SGTC_236 1509-0011 5.31 µM -0.0324553021943792 0.478678542353872 no 1782 0.487054480457931 2471 3107280
SGTC_1247 0448-0043 5.84 µM -0.0327514901568547 0.478564320689256 no 1783 0.486936381342453 2500 3089013 YGL099W LSG1
SGTC_1700 st030840 7.9285 µM -0.0351224232948277 0.477650060364318 no 1784 0.485991060618757 2493 5499307
SGTC_648 0375-0473 33.3 µM -0.0354010635051668 0.477542620979512 no 1785 0.485879968345207 2474 1713139
SGTC_364 0083-0097 67.7 µM -0.0372798614789211 0.476818228337888 no 1786 0.485130931270691 2521 5207356
SGTC_200 k038-0079 37.545 µM -0.0373122538092644 0.476805739759016 no 1787 0.485118017585123 2501 3436683
SGTC_306 1672-3436 11.6 µM -0.0374064225774997 0.476769433945736 no 1788 0.485080475889988 2513 6797378
SGTC_110 0850-0284 111.64 µM -0.0381402933690866 0.476486504137187 no 1789 0.484787912602439 2463 3906265
SGTC_2767 sibutramine 71.45 µM -0.0391580551797171 0.476094145239833 no 1790 0.484382187543152 2502 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_1515 3460-0031 42.1 µM -0.0401624770724737 0.475706951756593 no 1791 0.483981796218554 2490 2876596
SGTC_988 1497-1057 103 µM -0.0404599650232531 0.475592277842499 no 1792 0.483863212085952 2466 3533044
SGTC_2369 9071472 200 µM -0.0410370500305593 0.47536983226473 no 1793 0.483633179537362 2552 17296037
SGTC_2545 solidagenone 89.61 µM -0.0412955688235193 0.475270185025449 no 1794 0.483530132812701 2468 6708572 An anti ulcer agent
SGTC_1635 st007035 42.4 µM -0.0422336367899828 0.474908615515892 no 1795 0.483156224096062 2477 3716403
SGTC_1774 st048371 48.465 µM -0.0423467293740028 0.47486502642876 no 1796 0.483111147010022 2488 4242727
SGTC_2730 imipramine 71.33 µM -0.0437558853945259 0.474321923156545 no 1797 0.482549495867769 2494 3696 A tricyclic antidepressant.
SGTC_1789 tunicamycin 25 nM -0.0446515954302866 0.473976732006637 no 1798 0.482192508217572 2555 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1292 0kpi-0043 232 µM -0.0468893014878799 0.473114444747596 no 1799 0.481300727446257 2509 3333905
SGTC_800 3448-7362 155 µM -0.048887221838108 0.47234466386368 no 1800 0.480504586091272 2490 15991913
SGTC_2064 5220758 200 µM -0.0492164900597761 0.472217809592714 no 1801 0.480373385012077 2573 788518
SGTC_1012 4112-3522 18 µM -0.0493019965792203 0.472184867708639 no 1802 0.480339314207261 2491 3112398
SGTC_3096 9117468 49.47 µM -0.0497046297028039 0.472029753516424 no 1803 0.480178883526285 2489 41316311
SGTC_2389 9091542 195.52 µM -0.0512438845250705 0.471436795744581 no 1804 0.479565591482554 2539 3626624 YOL127W RPL25
SGTC_2885 9057732 51.95 µM -0.0521963575845031 0.47106991196706 no 1805 0.479186117602891 2555 6471414
SGTC_3270 9137563 49.47 µM -0.052753905680377 0.470855160990537 no 1806 0.478963994131567 2635 17015724
SGTC_2246 7293507 91.5585 µM -0.0530684428664029 0.470734014338274 no 1807 0.478838687476418 2540 887656
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0534497698659371 0.470587146658773 no 1808 0.478686775618874 2627 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1957 st077035 62.4 µM -0.0535222732919247 0.470559222495081 no 1809 0.478657892280412 2520 705593
SGTC_1388 3346-4487 254 µM -0.0547512277999847 0.470085921798086 no 1810 0.478168328327137 2553 3345614
SGTC_3314 9135860 59.4275 µM -0.0548319434393205 0.470054837685922 no 1811 0.478136175745087 2514 25252478
SGTC_269 exalamide 29 µM -0.0569504291041614 0.469239061037317 no 1812 0.477292341425585 2534 3316 A derivative of salicylamide.
SGTC_2786 7743617 45.45 µM -0.0579199241711814 0.468865775225526 no 1813 0.476906206284549 2535 583674
SGTC_2438 5259590 200 µM -0.0581510378938094 0.468776793267836 no 1814 0.476814160390486 2568 1201127
SGTC_2888 9058547 12.99 µM -0.0587353765167332 0.46855182183869 no 1815 0.476581440790122 2527 16476514
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.0594443653974532 0.468278873324636 no 1816 0.476299088518115 2497 91467 include heat shock
SGTC_3033 9090887 49.47 µM -0.0596005834421411 0.468218734066881 no 1817 0.476236876838517 2511 19325384
SGTC_2686 alizarin 95.37 µM -0.0602108939940341 0.467983789789459 no 1818 0.475993834652897 2549 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1675 st018485 24.5 µM -0.0628480838986801 0.466968710170742 no 1819 0.474943738053569 2591 3323024
SGTC_812 4251-0442 148 µM -0.0639689842141895 0.466537329583323 no 1820 0.474497461610255 2506 5723007
SGTC_1992 st073643 23.3 µM -0.0645021498863904 0.466332153538866 no 1821 0.474285197658331 2508 3161292
SGTC_2684 capsaicin 100 µM -0.06475533163977 0.466234725732367 no 1822 0.474184403474823 2582 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_44 0929-0055 61.211 µM -0.0655958974296175 0.465911279045942 no 1823 0.473849777728704 2534 1379590
SGTC_1468 k284-1086 134 µM -0.0662214833254865 0.46567057045041 no 1824 0.473600746546879 2550 15996457
SGTC_2954 9074818 52.69 µM -0.0662990848724292 0.465640712340009 no 1825 0.473569855894821 2582 16648742
SGTC_283 0987-0079 11.7 µM -0.0689921545902821 0.464604642997057 no 1826 0.472497932175152 2529 411556
SGTC_264 promethazine 12.5 mM -0.0694002745787295 0.464447653116902 no 1827 0.472335505182906 2514 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1755 st041960 45.185 µM -0.0700166555691057 0.464210562811204 no 1828 0.472090201471993 2607 2257073
SGTC_994 3910-0338 138 µM -0.0710493786915253 0.463813355463017 no 1829 0.471679228122213 2617 3479481
SGTC_1282 0886-0010 32.4 µM -0.0737750805532725 0.462765166621522 no 1830 0.470594677907649 2554 2836211 YNL267W PIK1
SGTC_356 1634-0012 32.5 µM -0.0759584130901299 0.461925736024423 no 1831 0.469726092057498 2532 735457
SGTC_1180 1193-0155 285 µM -0.0764693296546954 0.461729327169994 no 1832 0.469522856949366 2609 2921347
SGTC_420 mitomycin C 81.9 mM -0.0770254333462045 0.461515557885259 no 1833 0.469301656091897 2537 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_140 0062-0056 502.533 µM -0.0773061579405937 0.461407650042825 no 1834 0.469189996120791 2523 3758964
SGTC_276 colchicine 750 µM -0.0789044508074626 0.460793335961287 no 1835 0.468554311524764 2654 2833 A microtubule depolymerizer.
SGTC_402 epigallocatechin gallate 10 µM -0.081280463491321 0.459880273645174 no 1836 0.4676094552261 2559 65064 An antioxidant.
SGTC_3103 9120822 49.47 µM -0.0818429069785881 0.459664166715005 no 1837 0.467385817832555 2632 17141819
SGTC_2583 asiatic acid 100 µM -0.0822271233375125 0.4595165466096 no 1838 0.467233052584381 2641 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1707 st032323 6.317 µM -0.0847070943091522 0.458563849937161 no 1839 0.466247127899386 2565 3132057 YMR211W DML1
SGTC_2229 7354935 190 µM -0.0858691783388631 0.45811750948714 no 1840 0.465785206554529 2561 318112
SGTC_3097 9117246 49.47 µM -0.0859571083151898 0.458083738937864 no 1841 0.465750256790865 2548 16423892
SGTC_1350 1495-0454 146 µM -0.0870588170048446 0.457660640386472 no 1842 0.465312380157986 2649 1069057
SGTC_316 k060-0003 58.6 µM -0.0874230216742573 0.457520782300259 no 1843 0.465167635391461 2694 6152314
SGTC_328 k915-0120 63.5 µM -0.087663122941639 0.45742858398666 no 1844 0.46507221518618 2677 6624543
SGTC_2556 citropten 84.59 µM -0.0877752202371611 0.457385539676958 no 1845 0.465027666558743 2554 2775 A potential DNA crosslinker.
SGTC_1947 st076332 61.6 µM -0.0887195469351372 0.457022946978051 no 1846 0.464652398792599 2558 24208416
SGTC_1497 4476-2978 41.3 µM -0.0900677817616129 0.456505327930744 no 1847 0.464116675781069 2654 1528379
SGTC_654 1124-0271 80.9 µM -0.0922247308299256 0.455677378303339 no 1848 0.463259744707005 2610 5403748
SGTC_2948 9070189 9.45 µM -0.0923408794211795 0.455632799840492 no 1849 0.463213605007565 2626 6473636 YDL196W YDL196W
SGTC_1450 4112-4260 37.6 µM -0.0925070394930096 0.455569027669878 no 1850 0.463147599249385 2558 1633175
SGTC_2457 5731572 11.68 µM -0.0926180801840102 0.455526410934123 no 1851 0.463103489789369 2611 2865357
SGTC_1901 st060216 58.6 µM -0.0936517936796996 0.455129702659521 no 1852 0.462692882483484 2574 688792
SGTC_3107 9121808 49.47 µM -0.0941968373992021 0.454920549196621 no 1853 0.462476398497553 2567 662681
SGTC_2088 5278280 127.392 µM -0.0945268714555171 0.454793908975671 no 1854 0.462345318837211 2622 791502
SGTC_2845 9003024 42.97 µM -0.0947332863073852 0.454714706082948 no 1855 0.462263339106778 2732 2990173
SGTC_2363 9053361 176 µM -0.0963599685384486 0.454090599428282 no 1856 0.461617342302423 2677 6469797 YMR079W SEC14
SGTC_3258 9138477 49.47 µM -0.097330603450043 0.45371825132617 no 1857 0.461231926665415 2589 4970355
SGTC_920 mycophenolic acid 780.421 nM -0.0984583242134573 0.453285694167114 no 1858 0.460784181786931 2608 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3173 9105693 49.47 µM -0.100667664929601 0.452438423733564 no 1859 0.459907140295403 2695 17096658
SGTC_3206 9114350 49.47 µM -0.102276081192471 0.451821740612184 no 1860 0.45926877008906 2614 17087243
SGTC_2480 5767542 37.17 µM -0.104084857854712 0.451128376202075 no 1861 0.458551003633148 2635 2867358
SGTC_2377 9073351 62.6 µM -0.105020855003206 0.450769635685798 no 1862 0.458179630164322 2580 7337946 YHR072W ERG7
SGTC_341 1486-1430 230 µM -0.10512287044116 0.450730538556993 no 1863 0.458139155930387 2594 2054753 YPL210C SRP72
SGTC_433 pimozide 108 µM -0.105288186525027 0.45066718264942 no 1864 0.458073568329631 2587 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1761 st044296 37 µM -0.106469741501299 0.450214398986596 no 1865 0.457604830854023 2582 1826700
SGTC_1554 st069299 38.7 µM -0.10725840568078 0.44991221102165 no 1866 0.457291990791287 2671 24207999
SGTC_1689 st020265 53.493 µM -0.107390673599571 0.449861533514974 no 1867 0.457239526554101 2627 5758320 YPR016C TIF6
SGTC_1503 4585-0012 61.3 µM -0.109141289085994 0.449190875059007 no 1868 0.456545213260148 2785 2922052
SGTC_2349 9023730 187.07 µM -0.112625924427309 0.447856349723373 no 1869 0.455163565546879 2682 4126287
SGTC_176 1486-1328 72.834 µM -0.113726976123233 0.447434797308832 no 1870 0.45472711370046 2674 22310231
SGTC_2596 sinensetin 100 µM -0.113789834459358 0.447410732938496 no 1871 0.454702198588118 2658 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2086 5274770 176.623 µM -0.114820035004408 0.447016363775648 no 1872 0.454293884223064 2660 689278
SGTC_227 fluconazole 33.516 µM -0.116392193870462 0.446414629652535 no 1873 0.453670860868061 2623 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2877 9040724 71.43 µM -0.117389233397508 0.44603308275526 no 1874 0.453275807793586 2671 6463895
SGTC_155 k072-0202 43.6 µM -0.118053507431349 0.445778906206788 no 1875 0.453012630729258 2597 5857737
SGTC_1562 morin hydrate 59.1 µM -0.121598607929083 0.444422795014177 no 1876 0.451608458010157 2769 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1781 st038725 66.3 µM -0.122382951157337 0.444122846641961 no 1877 0.451297870007977 2615 4270275 YIL048W NEO1
SGTC_1708 st033234 31.827 µM -0.123223551885669 0.443801419820206 no 1878 0.450965037991552 2723 674664
SGTC_761 k216-0224 480 µM -0.124296557707028 0.443391180252225 no 1879 0.450540236359478 2614 1340404
SGTC_2307 7538926 6.34 µM -0.124490417635046 0.443317068740073 no 1880 0.450463493490246 2692 96582
SGTC_820 1582-0060 59.9 µM -0.124542620327494 0.443297112296023 no 1881 0.450442828450776 2663 3848840
SGTC_3244 9134489 49.47 µM -0.125404842158081 0.442967516391271 no 1882 0.450101527445556 2710 16584271
SGTC_1507 4075-3230 155 µM -0.126621003500992 0.442502689478281 no 1883 0.449620186177838 2578 659771
SGTC_887 0885-0007 9.62 µM -0.127339269549492 0.442228199391874 no 1884 0.449335940334401 2784 5719458
SGTC_2208 7283366 200 µM -0.128658957407761 0.441723944397253 no 1885 0.448813756329541 2647 898663
SGTC_1817 st052116 64.4 µM -0.132437950504912 0.440280509778689 no 1886 0.447318949436119 2750 4361398
SGTC_1105 epirubicin 18.1 µM -0.133465461626861 0.439888175164242 no 1887 0.446912638744962 2635 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1379 2144-0755 36.5 µM -0.133710823648378 0.439794497288803 no 1888 0.446815622995864 2714 5392327
SGTC_299 1273-0059 1.44 µM -0.134549370870703 0.439474370029659 no 1889 0.446484086832479 2710 2848077
SGTC_1765 st044815 90.4 µM -0.13651232680796 0.438725138958135 no 1890 0.445708140195459 2718 645695
SGTC_2736 butenafine 14.65 µM -0.137407422386161 0.438383567004438 no 1891 0.44535438224119 2677 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1109 tnp00067 928.257 nM -0.137816318395857 0.438227545952612 no 1892 0.445192793606259 2665 676295
SGTC_1895 st058434 18.3 µM -0.138941031649124 0.437798442558698 no 1893 0.444748373419088 2715 5393175
SGTC_2010 4012422 159 µM -0.139029494464567 0.437764695101546 no 1894 0.444713421082764 2722 952393
SGTC_2959 9079155 11 µM -0.139067594938553 0.43775016038693 no 1895 0.444698367425933 2808 16189457
SGTC_495 decylubiquinone 155 µM -0.139502840154021 0.437584127341435 no 1896 0.444526405883876 2709 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_545 4218-0007 221 µM -0.139946670543013 0.437414830625726 no 1897 0.444351063167552 2735 2840508
SGTC_1555 citronellol 128 µM -0.140472728163643 0.437214183615574 no 1898 0.444143249296732 2657 8842 A terpine precursor.
SGTC_1237 0330-0133 46.1 µM -0.140637334265585 0.43715140346117 no 1899 0.444078226432453 2673 X1237 YHR072W ERG7
SGTC_3225 9130819 49.47 µM -0.141138531134777 0.436960258592937 no 1900 0.443880252428655 2669 4547121
SGTC_1743 st037606 46.3785 µM -0.141378383467069 0.436868789676611 no 1901 0.443785515115165 2689 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2614 arthonioic acid 13.39 µM -0.141383040644935 0.436867013671346 no 1902 0.443783675646299 2639 6710684
SGTC_840 0245-0196 390 µM -0.142826085109592 0.436316773066984 no 1903 0.443213767671129 2784 3827528
SGTC_3217 9129673 49.47 µM -0.143170014132425 0.436185649226574 no 1904 0.443077955539185 2801 17248312
SGTC_426 0988-0037 14.6 µM -0.146439047957753 0.434939673649573 no 1905 0.441787401866735 2633 5383008
SGTC_2575 plumbagin 510 nM -0.150235138556206 0.433493624184934 no 1906 0.440289551966081 2650 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_805 3852-0218 479 µM -0.150503650048639 0.433391373241933 no 1907 0.440183635608641 2684 6615355
SGTC_107 0358-0022 2.6945 µM -0.152122110784999 0.43277514740679 no 1908 0.439545312637218 2748 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1847 st056231 15 µM -0.152798108683451 0.432517810803929 no 1909 0.439278744636585 2672 5393180
SGTC_1785 bathophenanthroline 24 µM -0.153640520351418 0.432197164436987 no 1910 0.438946592811009 2699 72812 An iron chelator.
SGTC_2998 9066762 71.4286 µM -0.154136688705036 0.432008329221976 no 1911 0.438750980264895 2819 4945196
SGTC_1804 st050076 49.1 µM -0.154146666989031 0.432004531776198 no 1912 0.438747046516468 2771 3895976
SGTC_422 cantharidin 155 µM -0.15427773075617 0.431954653287204 no 1913 0.438695377684224 2653 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1259 0671-0132 43 µM -0.154480405632492 0.431877524139462 no 1914 0.438615479900248 2712 X1259
SGTC_606 k015-0008 38.6 µM -0.154883673362654 0.431724065896438 no 1915 0.438456512543493 2802 1970475
SGTC_447 ml7 120 µM -0.15505489685315 0.431658912158549 no 1916 0.438389019577086 2747 4216 Selective myosin light chain kinase inhibitor.
SGTC_2568 diosmetin 100 µM -0.157706339731888 0.430650226959724 no 1917 0.437344102315767 2690 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_631 k072-0230 41.5 µM -0.157955216450621 0.43055557020884 no 1918 0.437246043853417 2796 5773147
SGTC_2421 5690543 90.72 µM -0.158750298408923 0.430253198756098 no 1919 0.436932804111876 2768 3397993
SGTC_2163 5671233 125 µM -0.159823807058399 0.429845005922866 no 1920 0.436509934911624 2775 701023
SGTC_3205 9113483 49.47 µM -0.160050825060261 0.429758693785141 no 1921 0.436420518806759 2868 17018033
SGTC_34 0469-0683 81.75 µM -0.160656958911351 0.429528258438281 no 1922 0.436181795396 2775 3690923
SGTC_2448 5185112 27.17 µM -0.161438513919023 0.429231168261345 no 1923 0.435874017381806 2826 5718189
SGTC_2857 9024691 58.44 µM -0.162040130423594 0.429002504864661 no 1924 0.435637125970817 2806 16478292
SGTC_861 0443-0273 110 µM -0.162933549570236 0.428662976620637 no 1925 0.435285377521422 2777 6149169
SGTC_1303 1160-0052 261 µM -0.163155288105925 0.428578716954393 no 1926 0.435198084663903 2708 3562476
SGTC_3203 9113543 49.47 µM -0.163306260854294 0.42852134983799 no 1927 0.435138652315196 2877 17018012
SGTC_586 0957-0265 8.15 µM -0.163539162884096 0.428432853929018 no 1928 0.435046970333746 2685 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2393 9031399 185.94 µM -0.164453438341417 0.428085491025994 no 1929 0.434687099223133 2837 1526623 YDL150W RPC53
SGTC_2131 toluylene red 5.2905 µM -0.165727438868913 0.427601549873146 no 1930 0.434185725777072 2734 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_809 3998-0021 90 µM -0.167989874775269 0.426742411058337 no 1931 0.433295622319646 2731 715485
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.168400994030941 0.426586329562105 no 1932 0.433133913074429 2724 279621
SGTC_141 0443-0274 32.331 µM -0.168807164680491 0.426432138094009 no 1933 0.432974161302879 2809 1627241
SGTC_1321 1326-2144 215 µM -0.169221911812269 0.426274702403856 no 1934 0.43281104760082 2829 3513030
SGTC_2016 5121758 140 µM -0.169387900375008 0.426211697364747 no 1935 0.432745770044451 2672 2795203
SGTC_358 0075-0058 9.45 µM -0.169821811610215 0.42604700458991 no 1936 0.432575136448888 2622 1069125
SGTC_3062 9077494 49.47 µM -0.170325361568961 0.425855896324737 no 1937 0.432377133509837 2815 16459633
SGTC_3154 9100113 49.47 µM -0.171435893719684 0.425434486603321 no 1938 0.431940516712276 2721 25237525
SGTC_2834 9001755 58.44 µM -0.17146943662603 0.425421759517545 no 1939 0.431927330274446 2827 2989575
SGTC_1569 carminic acid 40.6 µM -0.171811305914737 0.425292049498599 no 1940 0.43179293843326 2804 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_661 1304-0007 33.6 µM -0.172043438537497 0.425203979723386 no 1941 0.431701689544709 2723 3117130
SGTC_1647 st011722 22.4 µM -0.172129021987316 0.42517151079872 no 1942 0.431668048511363 2855 2854783
SGTC_1899 st063254 59.6 µM -0.174736716141644 0.424182439744133 no 1943 0.430643258138885 2690 3093813
SGTC_904 1141-0088 396 µM -0.174742975113153 0.424180066353586 no 1944 0.430640799002228 2763 1378119
SGTC_725 1497-0963 19 µM -0.175773047295074 0.423789502392488 no 1945 0.430236122536824 2821 3549977
SGTC_2236 dapsone 200 µM -0.176003100521034 0.423702285222733 no 1946 0.430145753304709 2739 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1302 1159-0335 255 µM -0.17624656998078 0.423609985796939 no 1947 0.43005011790912 2704 649284
SGTC_1167 k781-0610 148 µM -0.176324097595353 0.423580595908888 no 1948 0.430019665734824 2775 4525169
SGTC_109 0132-0036 33.701 µM -0.176994517606082 0.423326464616293 no 1949 0.429756347955068 2686 67274 A color developer.
SGTC_2641 levomentholum 100 µM -0.17832067143501 0.422823863062367 no 1950 0.429235572761089 2732 16666
SGTC_1701 st028638 40.4 µM -0.1790969491175 0.422529718336508 no 1951 0.428930788764596 2810 3490878
SGTC_1851 st056236 18.9 µM -0.179232172056835 0.422478484493674 no 1952 0.428877701539621 2739 5393171
SGTC_2629 bisabolol 100 µM -0.18183214211469 0.421493652801136 no 1953 0.427857229613264 2885 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3164 9100705 49.47 µM -0.183441468555057 0.420884308386175 no 1954 0.427225820334491 2885 17174235
SGTC_1559 coumarin 343 70.1 µM -0.183805722428561 0.420746416023673 no 1955 0.427082933388764 2869 108770 A hepatotoxic, DNA x-linker.
SGTC_1211 1056-0033 32.3 µM -0.185062882490692 0.420270578868247 no 1956 0.426589857086041 2752 6741922
SGTC_951 1171-0579 82.7 µM -0.185172116240237 0.420229239205322 no 1957 0.426547019439872 2685 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2481 5478948 45.16 µM -0.185843587924046 0.419975139169276 no 1958 0.426283710843758 2866 77792
SGTC_727 3032-0951 202 µM -0.187397149364291 0.419387364499871 no 1959 0.425674628745853 2805 3652836
SGTC_1509 1326-1131 80 µM -0.187518585801256 0.419341427781006 no 1960 0.425627026391869 2733 768313
SGTC_1254 0550-0035 264 µM -0.187589363720806 0.419314654566155 no 1961 0.425599282372432 2878 15121435
SGTC_172 1112-0046 2.638 µM -0.187819057147017 0.419227770841539 no 1962 0.425509248089467 2794 2802135 YIL048W NEO1
SGTC_732 3970-1727 52.7 µM -0.188255844001205 0.419062562925762 no 1963 0.425338048897141 2854 1275699
SGTC_938 3126-1755 342 µM -0.188397368290823 0.419009036597479 no 1964 0.425282581280244 2805 1777771
SGTC_2380 9035439 200 µM -0.189168185292749 0.418717529917813 no 1965 0.424980500952378 2883 6462575
SGTC_1667 st014849 34.6 µM -0.189245143550676 0.418688428380676 no 1966 0.424950343711515 2702 5348460
SGTC_962 1254-0300 21.5 µM -0.189888836256501 0.418445035333151 no 1967 0.424698120343561 2738 7340576
SGTC_2309 7664088 163.95 µM -0.192387970560158 0.417500359564632 no 1968 0.423719157249934 2850 704922
SGTC_2020 4017018 200 µM -0.19267463724392 0.417392029540408 no 1969 0.423606893897496 2845 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1168 k815-0004 80.5 µM -0.194111782417338 0.416849033643072 no 1970 0.423044178030803 2736 642433
SGTC_603 3794-0023 45.9 µM -0.194553562074352 0.416682148060392 no 1971 0.422871230179853 2831 3802260
SGTC_1827 berberine 7.24 µM -0.197729511458094 0.415482853071521 no 1972 0.421628349371518 2758 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3346 9158254 43.5805 µM -0.198423527918143 0.415220884489249 no 1973 0.421356855390012 2853 17639500
SGTC_961 1252-1571 372 µM -0.199068812039521 0.414977344582157 no 1974 0.421104458666777 2903 6813498
SGTC_3288 9119690 36.221 µM -0.19999071937005 0.41462945962723 no 1975 0.420743919686803 2817 17595618 YKL019W RAM2
SGTC_2116 5511452 16.8835 µM -0.200162680447122 0.414564576913889 no 1976 0.420676676595758 2878 870744
SGTC_1613 st002381 52.1 µM -0.202202483743288 0.413795116080836 no 1977 0.419879215744983 2764 551167
SGTC_2111 5486399 200 µM -0.2024109418014 0.413716499479816 no 1978 0.419797737559395 2762 689674
SGTC_1145 3546-0597 10.2 µM -0.204855632585442 0.41279478261398 no 1979 0.418842460039046 2811 875334
SGTC_2661 dactinomycin 12.96 µM -0.205338409898451 0.412612818715976 no 1980 0.418653868301262 2780 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1256 0570-0116 285 µM -0.205764941601688 0.41245207000887 no 1981 0.41848726385602 2798 410638
SGTC_1734 st037168 69.4 µM -0.206593601027091 0.412139811819301 no 1982 0.418163629049943 2859 708907
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.207401468305762 0.411835442132328 no 1983 0.417848167994416 2797 688801
SGTC_1779 st039427 55 µM -0.207741887002589 0.411707202863019 no 1984 0.417715254993899 2833 1124498
SGTC_2214 7179297 48.276 µM -0.207834063014203 0.411672480821095 no 1985 0.417679267428825 2762 769744
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.211014004471836 0.410475045018718 no 1986 0.416438171704525 2976 688798
SGTC_1916 st067606 49.2 µM -0.211790243025807 0.410182871570965 no 1987 0.416135340399401 2886 19590279
SGTC_2820 7989630 71.43 µM -0.211915232966824 0.410135830454548 no 1988 0.416086583147805 2836 2984098
SGTC_1218 1348-1416 30.7 µM -0.212757682396451 0.409818800609884 no 1989 0.41575798627489 2759 6787668
SGTC_421 streptovitacin 30 mM -0.213781906319065 0.409433444960062 no 1990 0.415358567719285 2985 91467 include heat shock
SGTC_639 0833-0042 114 µM -0.214419289587275 0.409193678997449 no 1991 0.415110050268093 2798 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2378 9074213 121.43 µM -0.214819825620204 0.409043025790154 no 1992 0.414953897561715 2792 657714
SGTC_1764 st044502 93.5 µM -0.216070146514023 0.408572830400356 no 1993 0.414466534844008 2912 8407
SGTC_881 0833-0569 170 µM -0.216281370338832 0.408493410590048 no 1994 0.414384214864871 2814 5418700
SGTC_339 3091-4833 71.4 µM -0.216431699838461 0.408436889234638 no 1995 0.414325629440199 2803 3240077
SGTC_3178 9107506 49.47 µM -0.216627407362913 0.408363309361582 no 1996 0.414249362446102 2925 8897194
SGTC_993 3909-8757 62.7 µM -0.220017886667464 0.407089110734375 no 1997 0.412928612229947 2843 4288324 YLR208W SEC13
SGTC_3300 9124615 50.48 µM -0.220377335196415 0.406954081367053 no 1998 0.412788647710122 2986 24824903
SGTC_2639 lactacystin 53 µM -0.220689793459746 0.406836713207972 no 1999 0.412666989587266 2943 3870 A proteasome inhibitor.
SGTC_5 0352-0601 109.883 µM -0.221286184360658 0.40661271515583 no 2000 0.412434803318262 2853 762456
SGTC_882 0843-0131 351 µM -0.221563896598826 0.40650841982703 no 2001 0.412326695137171 2787 5425421
SGTC_152 4469-0003 551.229 µM -0.221838920800653 0.406405140531003 no 2002 0.412219639913872 2804 697280
SGTC_332 4112-0506 40.9 µM -0.223693015025088 0.405709046436022 no 2003 0.411498090719388 2798 2790355
SGTC_1970 st070122 35.8 µM -0.223896269501659 0.405632755435806 no 2004 0.411419009278613 2977 102928
SGTC_2839 9003951 25.97 µM -0.22423823147849 0.405504409052433 no 2005 0.411285968199264 2792 2990634
SGTC_2677 mitomycin C 100 µM -0.225835388885488 0.404905093011658 no 2006 0.410664725832484 2824 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3356 9151811 4.48 µM -0.225950276677747 0.404861991190417 no 2007 0.410620046831577 2801 1859254 YPR165W RHO1
SGTC_502 l-744,832 89.3 µM -0.226395261989201 0.404695059395507 no 2008 0.41044700633146 2939 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_675 1309-0189 238 µM -0.227900807559036 0.404130397797276 no 2009 0.409861677450615 2851 4246530
SGTC_1881 5652484 16 µM -0.229383602040484 0.403574464259694 no 2010 0.409285390047138 2948 2255129
SGTC_1384 3089-0840 101 µM -0.230228386675155 0.403257822213343 no 2011 0.408957152437493 2934 1069836
SGTC_1735 st034310 56.75 µM -0.230247951978965 0.403250489499787 no 2012 0.408949551174299 3019 871153
SGTC_3191 9110352 49.47 µM -0.231145397962755 0.402914179970774 no 2013 0.408600923718397 2786 17122424
SGTC_2129 girgensonine 121.053 µM -0.232068287057486 0.402568410770008 no 2014 0.408242487891925 2886 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1369 1866-0067 208 µM -0.232197721483791 0.402519923014852 no 2015 0.408192223697026 2935 3531355
SGTC_768 0384-0033 77.3 µM -0.233122600901461 0.402173495299414 no 2016 0.407833102679621 2827 3965305 YMR134W ERG29
SGTC_3318 9139014 38.6185 µM -0.233456665537851 0.402048385159157 no 2017 0.407703407888142 2796 16643984
SGTC_1035 k081-0041 55.2 µM -0.234384448826415 0.401700974845565 no 2018 0.407343265239348 2915 731709
SGTC_1222 0366-0074 1.18 µM -0.23440471957518 0.401693385289075 no 2019 0.407335397506422 2963 286520
SGTC_1525 8-methoxypsoralen 92.5 µM -0.234981836527689 0.401477322910864 no 2020 0.407111415454583 3083 4114 Related to psoralen; DNA damaging agent.
SGTC_2140 5586273 200 µM -0.236243070279128 0.40100524422232 no 2021 0.406622029975957 2802 854421
SGTC_123 0083-0120 66.675 µM -0.236476986205623 0.400917705561543 no 2022 0.40653128163464 2826 16001701
SGTC_362 0310-0100 9.03 µM -0.236535581836536 0.40089577802153 no 2023 0.406508550080909 2959 790235
SGTC_2271 7849410 118.62 µM -0.23684892303858 0.400778525403165 no 2024 0.406386998032753 2799 972430
SGTC_1915 st067105 30.6 µM -0.237505359110506 0.400532915301441 no 2025 0.406132381081559 2791 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_3043 9092303 49.47 µM -0.238399575406668 0.400198401368733 no 2026 0.405785598355221 2845 25236084
SGTC_2317 5986382 200 µM -0.238609336650554 0.400119943183727 no 2027 0.405704262314198 2891 877883
SGTC_1854 st056233 32.9 µM -0.239177298993228 0.399907525258107 no 2028 0.405484052330193 2837 5393174
SGTC_2850 9015429 58.44 µM -0.241919462609885 0.398882373746956 no 2029 0.404421284506113 2891 6457570
SGTC_592 k241-0073 46.5 µM -0.242182418744571 0.398784104726118 no 2030 0.404319408712139 2953 4230158
SGTC_2243 6634756 200 µM -0.242470001462825 0.398676639879959 no 2031 0.404207999390407 3105 885676
SGTC_73 0327-0325 16.231 µM -0.244525154988017 0.397908887485517 no 2032 0.403412061147771 2979 53298
SGTC_1794 st048918 76.9 µM -0.245273976228185 0.397629245235212 no 2033 0.403122150189153 2830 672303
SGTC_2932 9016711 44.54 µM -0.247300370174225 0.396872766197359 no 2034 0.402337886163262 2966 7117328
SGTC_3144 9087057 49.47 µM -0.248181367021099 0.396543999508325 no 2035 0.401997041202165 2853 17249618
SGTC_1795 st049545 62.3 µM -0.249220003763675 0.396156499897514 no 2036 0.401595303370041 2894 5291882
SGTC_108 0509-0257 621.132 µM -0.24978488146366 0.395945795637789 no 2037 0.401376856032492 2936 536624
SGTC_2112 5488546 200 µM -0.250230342441584 0.395779656282148 no 2038 0.40120461080417 2841 600757
SGTC_2174 5790901 200 µM -0.2505268618793 0.395669076734233 no 2039 0.40108996705181 2931 786020
SGTC_2275 7947463 200 µM -0.251303287811965 0.395379567801782 no 2040 0.400789816704215 2894 1225414
SGTC_1460 k062-0059 9.15 µM -0.252376622716942 0.394979444370722 no 2041 0.40037498390133 2752 1373085
SGTC_1344 1488-0097 29.1 µM -0.253549020152262 0.39454251842647 no 2042 0.399921992864082 2953 747966
SGTC_1481 3346-2004 36 µM -0.253729992423315 0.394475085967157 no 2043 0.399852080760714 2875 2770522
SGTC_682 0kpi-0099 17 µM -0.254191541010274 0.394303121696003 no 2044 0.399673792665938 2958 1714895 YML126C ERG13
SGTC_621 3584-0052 32.1 µM -0.255467649752915 0.393827775031348 no 2045 0.399180963288481 2943 2273927
SGTC_774 k060-0086 136 µM -0.256983086692239 0.393263484800346 no 2046 0.398595914792515 2896 5911235
SGTC_3200 9114385 49.47 µM -0.257476722781562 0.393079722115488 no 2047 0.398405391124233 3003 17018030 YLR208W SEC13
SGTC_249 wiskostatin 11.211 µM -0.257748597954076 0.392978523090404 no 2048 0.398300468584728 2875 2775510 A n-wasp and actin depolymerizer.
SGTC_3031 9088762 49.47 µM -0.259068033417595 0.392487497664961 no 2049 0.397791374309865 2813 205253
SGTC_937 3122-0005 46.7 µM -0.25916625948997 0.392450949850282 no 2050 0.39775348146511 3021 759535
SGTC_263 alizarin 107.927 µM -0.259658357357823 0.392267865073826 no 2051 0.397563658533333 2878 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.259766013996271 0.392227814650488 no 2052 0.397522134052807 2806 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2997 9067075 71.4286 µM -0.260014466937798 0.392135389543732 no 2053 0.397426307151422 2968 27209819
SGTC_458 nppb 133 µM -0.261620405526049 0.391538123436017 no 2054 0.396807055240671 3065 4549 A chloride channel blocker.
SGTC_2154 5570129 200 µM -0.261738771336567 0.391494111994437 no 2055 0.396761423511898 2867 673366
SGTC_182 3448-4371 550.524 µM -0.261963959892413 0.39141038495399 no 2056 0.396674613976259 2859 3491403
SGTC_929 2805-0021 398 µM -0.263339694069141 0.390898984550537 no 2057 0.396144383794971 2945 3098024
SGTC_1678 st019265 80.2 µM -0.263749014175973 0.390746864730582 no 2058 0.395986662242176 3100 5367020
SGTC_2301 7769476 200 µM -0.264621634884847 0.390422619605849 no 2059 0.395650475936586 2937 977820
SGTC_2988 9073640 71.4286 µM -0.264759305765837 0.390371471330443 no 2060 0.395597443864731 3075 9102229
SGTC_702 1488-0190 94 µM -0.265740234989484 0.390007085850668 no 2061 0.395219637040118 2966 949357
SGTC_3118 9124250 49.47 µM -0.267293654256791 0.389430235467099 no 2062 0.394621536126414 2937 1504786
SGTC_1119 parthenolide 318.541 nM -0.267450363046603 0.389372056357603 no 2063 0.394561213527309 3090 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2385 9074692 200 µM -0.267588006654286 0.38932095736056 no 2064 0.394508231857529 2904 17046906
SGTC_678 1218-2179 85.9 µM -0.268425304310531 0.389010159119344 no 2065 0.394185981972187 2896 6820081 YOR116C RPO31
SGTC_1040 k898-0338 155 µM -0.269201943863299 0.388721940157234 no 2066 0.393887142242694 3094 20969351
SGTC_2049 5262831 67.185 µM -0.269860990716582 0.388477409088996 no 2067 0.393633599486169 2948 763417
SGTC_1702 st027038 51 µM -0.269888072898742 0.388467361529669 no 2068 0.393623181629074 2931 5521182
SGTC_1645 Cervolide 78 µM -0.270155499151059 0.388368149709299 no 2069 0.393520313340561 2954 23173 A fragrance.
SGTC_2695 st077686 51.995 µM -0.270526480738286 0.388230532205722 no 2070 0.393377623722631 2926 2876092
SGTC_265 mycophenolic acid 32.932 µM -0.270932951735505 0.388079765835504 no 2071 0.39322130035212 3124 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_258 haloperidol 50.781 µM -0.271193776383193 0.387983030828126 no 2072 0.393120999707276 2926 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2628 lathosterol 100 µM -0.274132124178699 0.386893733866305 no 2073 0.391991543775319 3039 6710616
SGTC_1984 st072354 53.1 µM -0.274826621047687 0.386636401487857 no 2074 0.391724722343731 2868 5762938
SGTC_2238 6671620 73.2395 µM -0.275002870771721 0.386571103487046 no 2075 0.391657016378905 2824 729941
SGTC_75 0159-0059 199.013 µM -0.276106094223238 0.386162448018819 no 2076 0.391233290019767 3198 5377270
SGTC_381 3461-2219 42.7 µM -0.276360265344561 0.386068315960911 no 2077 0.391135686180863 3011 2883159
SGTC_1778 st046819 58.9 µM -0.277351218949715 0.385701381233779 no 2078 0.390755217221633 2911 671715
SGTC_558 k064-0027 21.3 µM -0.277869475699534 0.385509519513197 no 2079 0.390556278175 2995 5088526
SGTC_2040 5100729 123 µM -0.280592418659954 0.384501931151308 no 2080 0.389511515779162 2896 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2316 5844804 197.44 µM -0.281558970761428 0.384144458737688 no 2081 0.389140852197805 3024 776813
SGTC_61 0978-8327 98.565 µM -0.283329643803095 0.383489843703177 no 2082 0.388462077704809 2990 6150059 YHR072W ERG7
SGTC_819 1013-0258 27.7 µM -0.284299360117848 0.383131481871305 no 2083 0.38809048823663 2932 5753198
SGTC_2469 5655019 90.81 µM -0.284413476247274 0.383089316452951 no 2084 0.388046766351131 3033 2788239
SGTC_3344 9148862 3.898 µM -0.286887570671798 0.382175490570692 no 2085 0.387099203905229 3078 4905352
SGTC_1930 st074634 34.3 µM -0.287170885903847 0.382070887664213 no 2086 0.386990738774379 2889 684253 YOR116C RPO31
SGTC_234 nsc-17383 10.7 µM -0.287234963712338 0.38204723066955 no 2087 0.386966208284977 3064 408974
SGTC_1606 st000094 49.2 µM -0.287467798232509 0.381961273806623 no 2088 0.386877077566061 3060 1242210
SGTC_1135 dihydrocapsaicin 536.708 nM -0.287519348375502 0.381942243529553 no 2089 0.386857344609227 2859 107982 A Capsaicinoid.
SGTC_438 sphingosine 6.67 µM -0.289373256719013 0.381258043715368 no 2090 0.386147879010684 2896 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1143 3454-2408 5.08 µM -0.289750531751649 0.381118852684559 no 2091 0.386003547491935 2904 X1143
SGTC_2532 xanthone 78.9 µM -0.290097658291651 0.380990798157404 no 2092 0.385870763610649 3016 7020 An insecticide.
SGTC_1424 4048-1941 275 µM -0.290371683384683 0.380889719862563 no 2093 0.385765952156161 3048 X1424
SGTC_3211 9128781 49.47 µM -0.29164137387691 0.380421481526626 no 2094 0.385280419063076 3033 17194361
SGTC_449 xestospongin c 11.1929 µM -0.291739825948273 0.380385181534749 no 2095 0.385242778223948 3032 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1938 st074717 56.4 µM -0.292580358114437 0.380075314151195 no 2096 0.384921464524564 2868 17250979
SGTC_674 0498-0004 451 µM -0.294790010009337 0.379261079890935 no 2097 0.38407714918008 2987 4231473
SGTC_334 1502-1024 68.5 µM -0.295210527664372 0.379106183931755 no 2098 0.38391653014085 3005 3296216
SGTC_832 4083-0019 164 µM -0.295714145710738 0.378920703826308 no 2099 0.383724196688393 3058 1990758
SGTC_277 nystatin 15.5 µM -0.296235963195217 0.378728550362925 no 2100 0.383524943021663 2881 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.296880463918094 0.378491261543629 no 2101 0.38327888582689 3095 5393153
SGTC_166 k072-0058 166.424 µM -0.298337985476884 0.37795480813591 no 2102 0.38272260765931 3034 5846229
SGTC_2757 clomiphene 4.22 µM -0.300069257898146 0.377317904095756 no 2103 0.382062163966997 3161 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_3187 9109394 49.47 µM -0.300950161238724 0.376993963493661 no 2104 0.381726249589386 2973 17098090
SGTC_1414 3917-0015 5.4 µM -0.301712981458402 0.376713516328142 no 2105 0.381435435711584 3039 6618702
SGTC_1498 4478-3555 97.6 µM -0.301814500702069 0.376676198170353 no 2106 0.381396738050466 2943 3437919
SGTC_604 1000-0114 314 µM -0.302488702257861 0.376428393032729 no 2107 0.381139772311432 3082 1572745
SGTC_3272 9137413 49.47 µM -0.304357251393802 0.375741867687964 no 2108 0.38042786613443 2907 17614870
SGTC_1814 st052110 31.539 µM -0.30442803085898 0.375715870255452 no 2109 0.380400907518538 3079 674163
SGTC_815 1582-0027 36.9 µM -0.305043454806853 0.375489847658872 no 2110 0.380166528183562 3028 3128206
SGTC_644 1498-1197 63.3 µM -0.305978980344035 0.375146345382272 no 2111 0.379810324994104 3048 6741615
SGTC_1924 st058459 75.1 µM -0.306053560602482 0.375118965578031 no 2112 0.379781932797845 2892 688683
SGTC_198 3454-2873 16.191 µM -0.30643134952918 0.374980281884449 no 2113 0.379638121086273 2955 710957
SGTC_1855 st056195 39.6 µM -0.306527645724434 0.37494493480364 no 2114 0.379601466981038 3125 4028379
SGTC_1763 st044482 94.5 µM -0.306806813600334 0.374842467643017 no 2115 0.379495210864286 3084 88505
SGTC_1090 efavirenz 20.7 µM -0.308206512753038 0.37432884845835 no 2116 0.378962598535977 2997 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2752 diclazuril 33.15 µM -0.312345386913934 0.372811397307849 no 2117 0.377389025192259 3093 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_714 4296-0578 26.1 µM -0.314019559701275 0.372198147668332 no 2118 0.37675309156729 2954 1589775
SGTC_3065 9113888 49.47 µM -0.315750802928007 0.371564333847285 no 2119 0.376095831307834 3155 16648368
SGTC_384 k007-0144 5.16 µM -0.31728061558113 0.371004553995742 no 2120 0.375515342314729 3015 6824886
SGTC_1068 loratadine 26.9 µM -0.318895219060274 0.370414043951445 no 2121 0.374902984920629 3015 3957 A H1 histamine antagonist.
SGTC_3184 9108758 49.47 µM -0.320436349239481 0.369850690013546 no 2122 0.374318787146389 2914 902885
SGTC_2513 baicalein 25.65 µM -0.321706833289511 0.369386479566908 no 2123 0.373837400314253 3020 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1590 st077108 57.8 µM -0.323380973541692 0.368775071682853 no 2124 0.37320336851638 3082 5489485
SGTC_168 3970-0862 530.542 µM -0.323460713741861 0.368745958267416 no 2125 0.373173177790181 3050 3135186
SGTC_1716 st033144 30.6155 µM -0.323854068951381 0.368602353982153 no 2126 0.373024259546949 3148 674617
SGTC_1289 0976-0073 69.1 µM -0.323917485613149 0.368579203840041 no 2127 0.373000252747536 3077 3391136
SGTC_1239 0337-0584 35.4 µM -0.324031917994315 0.368537431705181 no 2128 0.372956934855804 3147 914301 YML130C ERO1
SGTC_79 0052-0007 94.094 µM -0.327761537490379 0.367176832977646 no 2129 0.371545985433614 3132 2801472
SGTC_1070 indatraline 8.81 µM -0.327973962276664 0.367099388501972 no 2130 0.371465674898183 2990 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2191 5911152 200 µM -0.329410634185255 0.366575757904147 no 2131 0.370922665504317 3030 2875902
SGTC_2282 7944268 200 µM -0.329607789663193 0.366503919065073 no 2132 0.370848167975801 3187 2970414
SGTC_1299 1079-1439 3.74 µM -0.329724087088194 0.366461545199875 no 2133 0.370804225888507 3012 323161
SGTC_1670 st016595 4.04 µM -0.330937654133111 0.366019469882806 no 2134 0.370345789546243 3045 597879
SGTC_1883 5-benzylidenerhodanine 20 µM -0.331045511653062 0.365980188397134 no 2135 0.370305054253967 3097 1273210
SGTC_1138 3761-0006 1.03 µM -0.331972602907504 0.365642601651645 no 2136 0.369954973340634 2996 12061087
SGTC_1013 4112-3890 241 µM -0.33257110170053 0.365424722295234 no 2137 0.369729030133927 2955 705171
SGTC_659 k018-0002 107 µM -0.332895761753867 0.365306550203518 no 2138 0.369606484394942 3112 6797879 YHR007C ERG11
SGTC_118 0083-0097 135.343 µM -0.334365720180029 0.36477166437054 no 2139 0.369051801800093 3030 5207356
SGTC_2681 menadione 3.18 µM -0.334816323627545 0.364607752236856 no 2140 0.368881823027488 3077 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2967 9089538 49.85 µM -0.335599859039898 0.364322791260193 no 2141 0.36858631515721 3216 728216
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.335920552472273 0.364206181115952 no 2142 0.368465389055111 3003 390807
SGTC_3250 9135583 49.47 µM -0.336102283894402 0.364140105742981 no 2143 0.368396868106095 3133 7699353
SGTC_2769 toremifene 3.73 µM -0.337782539847503 0.363529376271717 no 2144 0.367763534262676 3211 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3019 9081971 49.47 µM -0.339981950705845 0.362730471506441 no 2145 0.366935060214819 3165 16451803
SGTC_1210 3013-0140 750 nM -0.341640091656504 0.362128569945513 no 2146 0.366310880935313 3131 905973
SGTC_2418 pentamidine 31.67 µM -0.342738136130378 0.361730169634804 no 2147 0.365897735013023 3101 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_979 1426-2828 121 µM -0.343016752485437 0.361629103880237 no 2148 0.365792928621577 3139 747872
SGTC_1703 st026983 48.3 µM -0.343868967465301 0.361320029958557 no 2149 0.365472415325842 3158 1104023
SGTC_1153 4055-0057 267 µM -0.344097869727114 0.361237029084584 no 2150 0.365386342454653 2996 882706
SGTC_2148 5546263 113.568 µM -0.344599211990626 0.361055263202472 no 2151 0.365197849142435 2988 792097
SGTC_867 0518-0118 155 µM -0.348775928946042 0.359542181973732 no 2152 0.363628767962868 3119 6848158
SGTC_204 PMA1.184 62.41 µM -0.349151599126164 0.359406197019511 no 2153 0.363487750295185 3026 2252213 YGL008C PMA1
SGTC_1776 st049249 45.9 µM -0.350936349683584 0.358760397151318 no 2154 0.362818050262961 3056 1822314
SGTC_2589 lobaric acid 100 µM -0.351690183352478 0.358487748675456 no 2155 0.362535311694082 3033 73157 A novel microtubule depolymerizer.
SGTC_2027 5150920 200 µM -0.352056842574722 0.358355160497674 no 2156 0.362397816791503 3074 786715
SGTC_2281 7943571 200 µM -0.352415794892328 0.358225375765716 no 2157 0.362263229121322 3247 1244024
SGTC_854 0422-0053 192 µM -0.352554572619272 0.358175202933342 no 2158 0.362211199555516 3057 3596728
SGTC_1956 st077085 54 µM -0.352618954992896 0.358151927363784 no 2159 0.362187062634808 3056 24208685
SGTC_2941 9056145 11.23 µM -0.353022966170903 0.35800588094132 no 2160 0.362035611551305 3058 2119517
SGTC_995 3931-2021 34.6 µM -0.355869607295043 0.356977435742836 no 2161 0.360969108806278 3129 730143
SGTC_295 k015-0027 31 µM -0.356198350671397 0.356858732850171 no 2162 0.36084601351256 3100 3887424
SGTC_602 3130-1533 38.1 µM -0.356869276956443 0.35661651732179 no 2163 0.360594835338827 3142 720941
SGTC_2335 9018011 154.17 µM -0.358601201760082 0.355991531150875 no 2164 0.359946723819459 3120 6458208
SGTC_3128 9127691 49.47 µM -0.359135240532402 0.35579889469187 no 2165 0.359746959813419 3143 41316314
SGTC_1420 4'-methoxyflavone 42 µM -0.361393851094821 0.354984584814392 no 2166 0.35890252198161 3126 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_530 4358-1714 28 µM -0.36364054360054 0.354175228457285 no 2167 0.358063223551036 3111 1564641
SGTC_2276 7947513 42.08 µM -0.364192817121906 0.353976376172 no 2168 0.357857015170416 3120 2105100
SGTC_1508 1080-0625 72.9 µM -0.364257230811936 0.353953185891469 no 2169 0.357832967028815 3001 767111
SGTC_1139 k015-0024 46.9 µM -0.364423013635585 0.353893503086741 no 2170 0.35777107643292 3175 2766652
SGTC_527 4476-4215 268 µM -0.364805824098377 0.353755702756534 no 2171 0.357628178643449 3061 4418754
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.368206391050823 0.352532443118112 no 2172 0.356359672612189 3110 75037 A free radical scavenger.
SGTC_2011 4012611 177 µM -0.368815673977704 0.35231343106069 no 2173 0.356132560450712 3031 2049887
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.370324381538068 0.351771323849991 no 2174 0.355570404656594 3172 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_749 1000-0129 128 µM -0.37118564065544 0.351461992121064 no 2175 0.35524963374109 3235 708470
SGTC_232 clozapine 119 µM -0.371247138441789 0.351439908199694 no 2176 0.35522673317014 3079 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2268 7933382 153.85 µM -0.372355450395972 0.351041998203167 no 2177 0.354814109199214 3067 935025 YOR257W CDC31
SGTC_2742 clothiapine 36.27 µM -0.372515753336139 0.350984459192001 no 2178 0.354754442579623 3118 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_3301 9125354 19.7965 µM -0.373177763873507 0.35074687385424 no 2179 0.354508072308454 3043 41905162
SGTC_2551 apiole 73.87 µM -0.375747971721506 0.349825019856532 no 2180 0.353552135262099 3026 10659 A possible DNA adduct former.
SGTC_1372 2752-0194 270 µM -0.37576740217682 0.349818054115963 no 2181 0.353544912003043 3072 823334
SGTC_253 dyclonine 31.25 µM -0.37660895583754 0.349516409027067 no 2182 0.353232115619204 3100 3180 An oral anasthetic.
SGTC_1381 2324-0066 62.1 µM -0.376850039213911 0.349430013001376 no 2183 0.353142525795279 3179 10885928
SGTC_3197 9113331 49.47 µM -0.376918678227044 0.349405416556072 no 2184 0.353117020103498 3284 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1669 st015249 58.4 µM -0.377132109837781 0.349328938451938 no 2185 0.353037714891763 3164 722793
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.378278798023662 0.348918154998019 no 2186 0.352611747012286 3086 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.378353578644038 0.348891372130874 no 2187 0.352583974169558 3167 368090
SGTC_1190 1486-1332 13 µM -0.380148817052245 0.34824862924199 no 2188 0.351917475111511 3122 4150046
SGTC_1976 st070609 63.5 µM -0.380475175880722 0.348131830876979 no 2189 0.351796360132695 3018 682556
SGTC_1923 st058458 19.1 µM -0.381048811879308 0.3479265710641 no 2190 0.351583514610764 3277 3534982
SGTC_2784 7567673 72.73 µM -0.38151813195707 0.347758670959544 no 2191 0.351409409723109 3146 3471247
SGTC_1540 guanosine 70.6 µM -0.382622991592215 0.347363523344141 no 2192 0.350999660203536 3117 6802 Guanosine is a purine nucleoside
SGTC_218 alverine citrate 93.75 µM -0.383180175025178 0.347164312305094 no 2193 0.350793088175979 3208 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_81 0411-0046 9.971 µM -0.38438624107066 0.346733249489271 no 2194 0.350346098374177 3137 12925265
SGTC_1579 chlormadinone acetate 49.4 µM -0.386216704463582 0.346079398470842 no 2195 0.349668091674506 3203 45114258 A steroidal progestin.
SGTC_705 1124-0212 310 µM -0.386555579569206 0.345958400779015 no 2196 0.349542624275386 3243 9554485
SGTC_105 0111-0055 734.78 µM -0.387915673649388 0.345472928160898 no 2197 0.349039219364061 3168 5179370
SGTC_1120 ficusin 1.78878 µM -0.388764023645636 0.345170246325147 no 2198 0.34872535817837 3219 6199 A DNA cross-linker.
SGTC_2737 bleomycin 30.5 nM -0.389227445522213 0.345004944363843 no 2199 0.348553951248185 3136 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_230 MPP+ 141.667 µM -0.389420013749126 0.34493626423201 no 2200 0.348482734679421 3135 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_739 1486-1183 203 µM -0.392277954869052 0.343917571136283 no 2201 0.347426425219374 3231 4346692
SGTC_221 trifluoperazine 10.304 µM -0.392565190359115 0.343815250538669 no 2202 0.34732032686655 3123 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2406 ethylparaben 405.7 µM -0.393285312349564 0.343558775045911 no 2203 0.347054382549948 2975 8434 A possible steroid mimic.
SGTC_2831 7999036 19.48 µM -0.39373038057039 0.343400297493705 no 2204 0.346890054485472 3300 2988270
SGTC_145 3737-0113 38.366 µM -0.394409583444675 0.34315850357251 no 2205 0.346639334745356 3231 6849351
SGTC_280 3448-3607 3.04 µM -0.394676158028593 0.343063621461747 no 2206 0.346540950223357 3204 626179
SGTC_2175 5807670 165.306 µM -0.395471998343729 0.342780416246989 no 2207 0.346247291514883 3216 241186
SGTC_936 3005-4620 401 µM -0.396161056875057 0.342535281398935 no 2208 0.345993109067264 3286 777207
SGTC_2124 5246320 200 µM -0.396527902074119 0.342404802048602 no 2209 0.345857814152847 3182 579342
SGTC_2121 5257820 149.641 µM -0.396572848516521 0.342388816809364 no 2210 0.345841238963183 3240 791256
SGTC_2082 5219693 150 µM -0.397705512124255 0.341986077342225 no 2211 0.345423636902805 3085 2834649
SGTC_1458 k015-0034 6.33 µM -0.398272147343027 0.341784667137664 no 2212 0.345214794556214 3147 3598957
SGTC_3053 9095903 49.47 µM -0.399188167025472 0.341459163651863 no 2213 0.344877280748879 3189 17174018
SGTC_193 1273-0060 1.558 µM -0.399613057039918 0.341308220898986 no 2214 0.344720768952726 3176 2847393 YHR072W ERG7
SGTC_379 3970-0972 5.9 µM -0.400775847634121 0.340895267819056 no 2215 0.344292581231949 3159 2898042 YBL034C STU1
SGTC_908 3448-7491 47.7 µM -0.401486120972979 0.340643115289826 no 2216 0.344031127248598 3081 1203031
SGTC_2303 7774051 200 µM -0.401719061628033 0.340560435054206 no 2217 0.343945397244884 3283 2953184
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.404738535427392 0.33948939394358 no 2218 0.342834856566605 3208 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1572 epiandrosterone 68.9 µM -0.408230572893269 0.338252344396562 no 2219 0.341552202317233 3084 441302 A steroid.
SGTC_574 1315-0397 40 µM -0.41058344673205 0.337419824473743 no 2220 0.340689001815612 3147 6794277
SGTC_2664 lyso-paf C-16 73.48 µM -0.411004894252617 0.337270787099613 no 2221 0.340534472967402 3117 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_3354 9151612 71.43 µM -0.411141018416376 0.337222654678847 no 2222 0.340484567108113 3252 27261949
SGTC_1757 st041620 31.8375 µM -0.412380527731582 0.336784496715435 no 2223 0.34003026663542 3182 5289815
SGTC_2204 7233102 200 µM -0.413100995460111 0.33652991807988 no 2224 0.339766310059421 3128 2172480
SGTC_2430 5571206 200 µM -0.413256540746096 0.336474965687121 no 2225 0.339709333494807 3279 1731771
SGTC_1607 st000305 50.6 µM -0.41428107850899 0.336113095379559 no 2226 0.339334134723085 3261 5457690
SGTC_2602 kawain 100 µM -0.414323407578919 0.336098147868338 no 2227 0.33931863670152 3199 5369129
SGTC_275 trichlorophene 5.69 µM -0.415348703071723 0.33573616819753 no 2228 0.338943326424284 3217 62616
SGTC_121 0557-0495 61.343 µM -0.417759138978519 0.334885766537689 no 2229 0.338061614341054 3175 3104427
SGTC_2461 5755302 26.15 µM -0.419165898497414 0.334389852471797 no 2230 0.33754744632894 3264 2788904
SGTC_3262 9137218 49.47 µM -0.419861650102386 0.334144691239989 no 2231 0.337293262369666 3153 17650664
SGTC_1500 4488-1866 171 µM -0.420450048388962 0.333937413188065 no 2232 0.337078356511594 3284 2900003
SGTC_1872 amphotericin b 148 nM -0.421254188564976 0.33365421657009 no 2233 0.336784739336275 3235 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2486 5283202 22.39 µM -0.422301928177581 0.333285372923951 no 2234 0.336402325471918 3162 1377751
SGTC_1411 3909-8223 150 µM -0.422609784332728 0.333177026627117 no 2235 0.33628999337517 3242 X1411
SGTC_2819 7996655 46.38 µM -0.422683989952944 0.33315091292722 no 2236 0.33626291904203 3153 6456960
SGTC_1641 st009299 47.1 µM -0.423675762106381 0.33280197608392 no 2237 0.335901147024977 3240 4046054
SGTC_3255 9139072 49.47 µM -0.427101915845861 0.331597662174687 no 2238 0.334652548793467 3228 17646060
SGTC_1159 4092-0538 61.2 µM -0.427662487589321 0.331400782979983 no 2239 0.334448432292037 3176 717301
SGTC_2184 6075246 200 µM -0.428680958848053 0.331043203477238 no 2240 0.334077709743481 3226 2267320
SGTC_553 k007-0256 45.7 µM -0.429551726454171 0.330737604033249 no 2241 0.33376087949022 3191 6287000
SGTC_1910 st062352 60.4 µM -0.431231583430382 0.330148370171961 no 2242 0.333149995655286 3101 2245730
SGTC_559 1550-0661 158 µM -0.433842200340226 0.329233494891559 no 2243 0.332201517279447 3238 5830875
SGTC_326 k292-0812 17.5 µM -0.435807768176009 0.328545347034207 no 2244 0.331488103626715 3244 3579357
SGTC_796 1234-0020 70.7 µM -0.437111355177968 0.328089279860819 no 2245 0.331015296324296 3198 46495034
SGTC_67 0335-0847 266 µM -0.437922004488094 0.327805798819729 no 2246 0.330721411902744 3422 4552207 YOR254C SEC63
SGTC_1791 st048313 56.1 µM -0.438034717090245 0.32776639149474 no 2247 0.330680558497431 3273 1204976
SGTC_53 0973-0023 39.979 µM -0.438155672114049 0.327724104533373 no 2248 0.330636719817158 3339 674768
SGTC_973 1325-0077 65.9 µM -0.438217739656372 0.327702406021473 no 2249 0.330614225091726 3201 2835149
SGTC_3120 9124077 49.47 µM -0.438588473940491 0.327572811231512 no 2250 0.330479875081546 3223 18774327 YGL155W CDC43
SGTC_217 ketoconazole 989 nM -0.440874458028464 0.326774176407355 no 2251 0.32965194285937 3242 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1059 3448-6867 171 µM -0.4411172522588 0.326689399972967 no 2252 0.329564057160954 3269 3934407
SGTC_1150 3909-7983 10.9 µM -0.441823357573959 0.326442900121578 no 2253 0.329308517447203 3196 23965914
SGTC_2187 6125751 200 µM -0.441869488712425 0.326426798475833 no 2254 0.329291825347886 3218 874498
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.443261788802126 0.325940981356195 no 2255 0.328788195470068 3403 6710655
SGTC_2447 5741742 33.78 µM -0.444262135856486 0.325592111204221 no 2256 0.328426536619103 3276 1776504
SGTC_1952 st077036 64.1 µM -0.446764847969524 0.324719962083692 no 2257 0.327522427201782 3253 2937007
SGTC_2475 5812728 15.03 µM -0.447409542233418 0.324495453316365 no 2258 0.327289693667861 3181 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_2491 paeonol 100 µM -0.447470936499893 0.324474076659672 no 2259 0.327267533941052 3170 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1172 0370-0043 85 µM -0.45073412958392 0.323338710568227 no 2260 0.326090590516477 3310 376585
SGTC_2696 st077691 74.316 µM -0.451449253343914 0.323090115978169 no 2261 0.325832895903968 3332 757133
SGTC_2287 7945887 168.79 µM -0.451716423730765 0.322997261250539 no 2262 0.325736642480381 3255 1245853
SGTC_3345 9148410 3.559 µM -0.451815069464462 0.322962979839391 no 2263 0.325701106336848 3295 4903596
SGTC_704 1310-0270 142 µM -0.452151480487082 0.322846081436412 no 2264 0.325579929527103 3233 5718033
SGTC_3281 9140613 49.47 µM -0.453255359916941 0.322462620847667 no 2265 0.325182436559694 3237 16013766
SGTC_1478 0453-0656 35.7 µM -0.454971849727754 0.321866729599424 no 2266 0.324564745478935 3289 5258496
SGTC_1609 st001574 46.4 µM -0.455599211776649 0.3216490507067 no 2267 0.324339105029436 3196 3960012
SGTC_20 0481-0013 4.944 µM -0.456472054865376 0.321346297890603 no 2268 0.324025280817698 3264 182045
SGTC_613 3914-0030 117 µM -0.458027060533318 0.320807225471882 no 2269 0.32346650001198 3123 1145395
SGTC_2539 epi(13)torulosol 80 µM -0.458381098117556 0.320684544312667 no 2270 0.323339334554774 3294 6708597
SGTC_1674 st016616 23.6 µM -0.458591061248325 0.320611797105492 no 2271 0.323263928417323 3147 625830
SGTC_484 loperamide 105 µM -0.460060684109276 0.320102800922747 no 2272 0.322736331616695 3219 3955 An opioid-receptor agonist.
SGTC_309 k408-0051 1.48 µM -0.461753991281951 0.319516752421713 no 2273 0.32212887401076 3285 3640463
SGTC_942 3253-1115 227 µM -0.462009816278238 0.319428251297684 no 2274 0.322037140512013 3367 46497897
SGTC_1727 st034309 9.9045 µM -0.464521296012583 0.318559966708883 no 2275 0.321137152748942 3401 870305
SGTC_1301 naphtanilide LB 4.81 µM -0.465188910010673 0.318329322273479 no 2276 0.320898089901305 3347 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1196 1588-0294 184 µM -0.467217867080068 0.31762879925888 no 2277 0.320172005898917 3252 6144269
SGTC_3080 9117754 49.47 µM -0.467429253542025 0.31755585290389 no 2278 0.320096398523128 3407 9550191
SGTC_1349 flufenamic acid 69 µM -0.470554051208631 0.316478358778825 no 2279 0.318979613436981 3222 3371 A non-steroidal anti-inflammatory.
SGTC_1803 st050068 52.4 µM -0.470564941461368 0.316474606312493 no 2280 0.318975724186379 3359 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2347 9049783 174.81 µM -0.471375202544931 0.316195466779435 no 2281 0.318686410487618 3352 6467988 YPL169C MEX67
SGTC_503 tyrphostin 8 294 µM -0.471611014098244 0.316114248030454 no 2282 0.318602231816877 3296 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_587 k089-0003 57 µM -0.471701779811373 0.316082988662765 no 2283 0.318569833282266 3308 9659696
SGTC_2777 climbazole 1.536 µM -0.473909406720284 0.315323095629824 no 2284 0.317782255477662 3304 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1530 rhein 70.4 µM -0.474666755006162 0.315062586450881 no 2285 0.317512258681975 3299 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2333 9017922 200 µM -0.476968730671596 0.314271328427054 no 2286 0.316692194135839 3341 3163164
SGTC_2729 fluphenazine 10.66 µM -0.477128530142322 0.314216432171347 no 2287 0.316635299930912 3219 3372 An atypical antipsychotic.
SGTC_1164 k060-0068 93.7 µM -0.478752252084477 0.313658864675531 no 2288 0.316057444243648 3263 5963676
SGTC_2971 9092186 9.93 µM -0.480477024712555 0.313067063422686 no 2289 0.315444118135519 3202 25236400
SGTC_1810 st050138 53 µM -0.480803741910274 0.312955014904374 no 2290 0.31532799526812 3332 3444541
SGTC_997 3996-0078 137 µM -0.48274058998149 0.312291122824889 no 2291 0.314639969451036 3277 735687
SGTC_746 1095-0025 46.6 µM -0.483140211165962 0.312154220660621 no 2292 0.314498092121746 3382 6749286
SGTC_856 0433-0016 11.3 µM -0.483842170662364 0.311913806283358 no 2293 0.314248942080532 3322 3911780
SGTC_935 2996-0153 430 µM -0.484211319360861 0.311787408539334 no 2294 0.31411795220197 3365 23738523
SGTC_2815 7968870 71.43 µM -0.486640695393125 0.310956135610226 no 2295 0.313256489465296 3285 2977326 YHR190W ERG9
SGTC_125 0133-0007 11.75 µM -0.488186204037976 0.310427801669058 no 2296 0.31270897777667 3404 26541
SGTC_2056 5235370 200 µM -0.489963300495798 0.309820782297459 no 2297 0.312079934272717 3234 5511916
SGTC_1188 1403-0014 4.57 µM -0.491568200079114 0.309273027010143 no 2298 0.311512314180511 3281 9614867
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.492646375289712 0.308905281548404 no 2299 0.31113123700688 3274 4330530
SGTC_607 4491-0986 66.8 µM -0.494007613222387 0.308441262165985 no 2300 0.310650401391335 3385 698981 YDR232W HEM1
SGTC_1657 st012939 43.4 µM -0.495463104669225 0.307945451907604 no 2301 0.310136629821935 3384 24207257
SGTC_88 0180-0332 8.668 µM -0.496488464599919 0.307596375389561 no 2302 0.309774911994329 3261 3101745
SGTC_346 4513-0042 7.16 µM -0.496958585320059 0.30743638432916 no 2303 0.309609128308227 3282 2827372
SGTC_3156 9099931 49.47 µM -0.499174668074337 0.306682702748038 no 2304 0.308828169409664 3226 18111053
SGTC_2003 4023581 200 µM -0.50001718926376 0.306396378477202 no 2305 0.308531487008231 3367 16641307
SGTC_296 1222-0039 74.9 µM -0.500376693010456 0.306274239884352 no 2306 0.308404930669831 3305 5984176
SGTC_65 0798-0905 34.986 µM -0.503032782949341 0.305372521766806 no 2307 0.307470611786004 3572 3602145
SGTC_2382 9035899 200 µM -0.503087502468912 0.305353957376497 no 2308 0.307451376484581 3283 6462679
SGTC_3100 9120536 49.47 µM -0.504171376347195 0.304986340661016 no 2309 0.307070476455083 3314 16421196
SGTC_2616 abietic acid 100 µM -0.505194024242196 0.304639670265649 no 2310 0.306711283530554 3415 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_751 0833-0568 350 µM -0.505547717017012 0.304519811720341 no 2311 0.306587096309637 3351 6954252
SGTC_2581 avocatin a 64 µM -0.509804416587381 0.303078960923102 no 2312 0.305094245595139 3277 6710728 A skin care supplement.
SGTC_3238 9133470 49.47 µM -0.510185798911039 0.302950015760604 no 2313 0.304960650131799 3408 3534688
SGTC_2373 9071805 200 µM -0.510543670188255 0.302829042005134 no 2314 0.304835314055153 3416 10149009
SGTC_1215 3852-0577 11.2 µM -0.512496182164658 0.302169401895534 no 2315 0.304151895802684 3423 2884876
SGTC_514 4466-0038 2.65 nM -0.513294815516579 0.301899776169627 no 2316 0.303872555012231 3285 5722064
SGTC_196 k015-0023 18.111 µM -0.513514472956877 0.301825636822288 no 2317 0.303795744727709 3318 5211998
SGTC_1792 st045773 43.6 µM -0.514109952256168 0.301624690282273 no 2318 0.303587559836001 3328 2919270
SGTC_2073 5212005 126 µM -0.514876094436644 0.301366241516447 no 2319 0.30331980341778 3306 691789
SGTC_3064 1327-0027 10 µM -0.514899545218431 0.301358332252591 no 2320 0.303311609349057 3327 16000455 YPR107C YTH1
SGTC_1547 harmine 94.2 µM -0.514917481541481 0.301352282917702 no 2321 0.303305342184957 3395 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1808 st050063 61.5 µM -0.515711106031909 0.301084674091284 no 2322 0.303028098332628 3411 4011993
SGTC_3068 9116768 49.47 µM -0.517374491049468 0.300524131278663 no 2323 0.302447381578723 3386 41904888
SGTC_3315 9136395 68.55 µM -0.517430735013201 0.300505185909092 no 2324 0.302427754553418 3464 16876844
SGTC_1958 st076513 41.9 µM -0.518211115125617 0.300242376234502 no 2325 0.30215549024473 3284 732122 YGL099W LSG1
SGTC_2934 9036370 36.88 µM -0.519264583619997 0.299887763119708 no 2326 0.301788123636507 3345 6462800
SGTC_2770 toltrazuril 17.5 µM -0.519355875733227 0.299857041769236 no 2327 0.30175629761282 3412 68591 Kills coccidiodes.
SGTC_2180 6301957 200 µM -0.519643278645401 0.299760335100188 no 2328 0.301656113796147 3389 845462
SGTC_1428 4049-0204 61.7 µM -0.521137552233399 0.299257762755748 no 2329 0.301135476422193 3408 X1428
SGTC_2801 7907800 81.82 µM -0.521969060627656 0.29897826535151 no 2330 0.300845936289794 3367 6620925
SGTC_596 1155-0152 116 µM -0.524417189997391 0.298156057503268 no 2331 0.299994201455024 3377 280313
SGTC_2980 9014342 25.29 µM -0.524648259780874 0.298078505600436 no 2332 0.299913865768812 3443 2996599
SGTC_524 r073-0010 27.8 µM -0.52544998706126 0.297809500276598 no 2333 0.299635205976037 3312 2772106
SGTC_738 1315-0003 72.4 µM -0.525970189314612 0.297635014917362 no 2334 0.299454459819845 3430 6251474
SGTC_2183 6420625 130.508 µM -0.526365839615408 0.297502337807989 no 2335 0.299317022794505 3432 2897619
SGTC_1175 0741-0056 27.6 µM -0.527276347200239 0.297197111426395 no 2336 0.299000848559211 3469 765927
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.527406641969105 0.297153444861096 no 2337 0.298955616040132 3378 1241132 A phosphatase inhibitor.
SGTC_2428 5615643 7.78 µM -0.528309763557774 0.296850856285164 no 2338 0.29864217806463 3392 2253075
SGTC_485 niflumic acid 177 µM -0.52945706109967 0.296466660675702 no 2339 0.298244211860409 3422 4488 A COX2 inhibitor.
SGTC_2450 5739737 12.93 µM -0.530280161232039 0.296191169544465 no 2340 0.297958849750538 3416 2262825
SGTC_1999 st074831 12.5 µM -0.530329525605732 0.296174651051027 no 2341 0.29794173948107 3330 17112523
SGTC_124 0136-0217 7.121 µM -0.531220266811312 0.295876660505126 no 2342 0.297633075150002 3519 3976905
SGTC_38 0929-0051 58.268 µM -0.532115937480325 0.29557715976144 no 2343 0.297322849869173 3382 1379719
SGTC_519 k048-0011 62.8 µM -0.53216914631724 0.295559371798131 no 2344 0.297304425059389 3383 6836379
SGTC_2036 5160441 105 µM -0.532329357449962 0.295505815438672 no 2345 0.297248951341456 3356 134534 YIL048W NEO1
SGTC_2193 5925765 200 µM -0.532573906819022 0.295424074582984 no 2346 0.297164284308745 3418 877370
SGTC_340 k038-0059 454 µM -0.533752060139163 0.295030421567938 no 2347 0.296756542745377 3393 23733424
SGTC_1094 duloxetine 25.4 µM -0.533906730078089 0.294978760089642 no 2348 0.296703032776284 3337 60834 A selective serotonin reuptake inhibitor.
SGTC_926 2268-1401 59.4 µM -0.533958613422735 0.294961431409591 no 2349 0.29668508408427 3417 2931578
SGTC_2252 omeprazole 400 µM -0.535625793815187 0.294404854503002 no 2350 0.296108599197253 3304 4594 A proton pump inhibitor.
SGTC_163 TUB2.036 7.546 µM -0.537390921390364 0.293816107577032 no 2351 0.295498806528097 3402 15992207 YJR013W GPI14
SGTC_2514 salinomycin 42.74 µM -0.537476581326897 0.293787550120398 no 2352 0.295469228577269 3458 23682228 A polyether potassium ionophore.
SGTC_719 2810-4230 27.3 µM -0.538251268647407 0.293529341877356 no 2353 0.295201794755985 3371 721079
SGTC_655 k060-0012 42 µM -0.538639806571886 0.293399879284849 no 2354 0.295067707540965 3340 5994525
SGTC_187 1488-2104 32.728 µM -0.53867615879098 0.293387767914647 no 2355 0.295055163565525 3404 2852859
SGTC_2876 9059903 25.97 µM -0.5391308422491 0.293236301832472 no 2356 0.294898287759223 3423 6916095
SGTC_3098 9119039 49.47 µM -0.539280780053666 0.293186361864196 no 2357 0.294846564344001 3427 17161528
SGTC_2645 abamectin 100 µM -0.539736653765822 0.293034547675433 no 2358 0.29468932919377 3409 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_205 1486-1330 71.903 µM -0.541034421656531 0.292602567305865 no 2359 0.294241928673028 3410 4118834
SGTC_1227 3909-8010 46.6 µM -0.541698312720249 0.292381696241141 no 2360 0.294013176144584 3334 15982272
SGTC_1912 st060209 90.8 µM -0.54274573002289 0.292033386890889 no 2361 0.293652441808745 3353 688787
SGTC_373 0844-0104 25.9 µM -0.542790807627279 0.292018401069153 no 2362 0.293636921516941 3434 5375804
SGTC_902 1120-0002 2.07 µM -0.545603820997983 0.291083938088323 no 2363 0.292669148630854 3432 3280475
SGTC_262 fenpropimorph 62.5 µM -0.546713724266845 0.290715620781522 no 2364 0.292287711945851 3395 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_624 k048-0052 28 µM -0.54813995706052 0.290242650929292 no 2365 0.291797903116121 3365 6835531
SGTC_298 1391-0729 10 µM -0.551993973711146 0.288966381456035 no 2366 0.290476241041086 3396 3237558
SGTC_1691 st019933 84.6 µM -0.552047951818902 0.288948525204425 no 2367 0.290457750183091 3431 6176082
SGTC_2211 7117706 200 µM -0.552958331799795 0.288647444803813 no 2368 0.290145971478584 3425 822771
SGTC_1300 1094-0077 113 µM -0.553489892077004 0.288471715816835 no 2369 0.289964000066082 3393 5532636
SGTC_1136 pergolide 1.05886 µM -0.554472233596143 0.288147095412033 no 2370 0.289627851589484 3350 47811 A dopamine receptor agonist.
SGTC_1020 4335-0961 93.3 µM -0.556319128578113 0.287537245415768 no 2371 0.288996356410771 3293 669075
SGTC_1758 st042942 75.2445 µM -0.556380261489202 0.28751706959229 no 2372 0.288975464765332 3440 669317
SGTC_2915 7971052 15.16 µM -0.557742950524345 0.287067512311855 no 2373 0.288509962084708 3370 5741558
SGTC_1862 st057513 3.81 µM -0.557972747056754 0.286991734207731 no 2374 0.288431497054439 3369 5393163
SGTC_2780 5215298 71.43 µM -0.558947507898996 0.286670400762033 no 2375 0.288098772583308 3476 2834131
SGTC_3059 1327-0034 3 µM -0.559067772676526 0.286630766868155 no 2376 0.288057734007944 3391 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2708 st078559 56 µM -0.559767151767269 0.286400334301064 no 2377 0.287819135935156 3416 17250902
SGTC_533 1222-0222 6.71 µM -0.559995086191482 0.286325253095924 no 2378 0.287741394685034 3505 3982874
SGTC_1455 4262-0120 131 µM -0.560652752548546 0.286108671328161 no 2379 0.287517141040319 3537 1529587
SGTC_1991 st073000 8.92 µM -0.560742041182245 0.286079272921636 no 2380 0.287486701425512 3546 4301969 YIL048W NEO1
SGTC_144 4161-2749 112.381 µM -0.561480928444031 0.285836048364762 no 2381 0.287234863996533 3400 797501 YMR168C CEP3
SGTC_3310 9130229 44.1445 µM -0.563408363516688 0.285202044657634 no 2382 0.286578421702015 3456 7761258
SGTC_1192 1488-0095 21.4 µM -0.566091101802846 0.284320711295123 no 2383 0.285665925947616 3442 915875
SGTC_2346 9031566 143.75 µM -0.566170629107215 0.284294604857636 no 2384 0.285638896962795 3381 4771086
SGTC_1314 1222-0010 41.1 µM -0.566622250351925 0.284146372831603 no 2385 0.285485427305994 3426 3526027
SGTC_818 4072-2707 53.5 µM -0.567650300534193 0.283809082048496 no 2386 0.285136222383722 3407 882871
SGTC_2902 5787006 60.46 µM -0.568787864798537 0.283436084572771 no 2387 0.284750055501773 3391 591003
SGTC_337 1315-0038 354 µM -0.569830406302529 0.283094450734505 no 2388 0.284396365172178 3421 1626437
SGTC_3160 9100216 49.47 µM -0.570570282798417 0.28285211813093 no 2389 0.284145483723945 3438 17191039
SGTC_917 harmaline 728.087 nM -0.570692592815328 0.282812067388135 no 2390 0.28410402035791 3421 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_1489 4065-0444 182 µM -0.570792685475427 0.282779293805271 no 2391 0.284070090878203 3464 2877968
SGTC_24 0417-1663 219 µM -0.57297653481314 0.282064685271596 no 2392 0.283330291026212 3474 4329390
SGTC_976 1348-1067 47.6 µM -0.573180827736021 0.281997880170734 no 2393 0.283261132127386 3482 5310671 YGL099W LSG1
SGTC_1269 0831-0796 3.05 µM -0.573455214964351 0.281908165773849 no 2394 0.28316825707764 3489 927758
SGTC_1086 cerivastatin 2.18 µM -0.574710463214581 0.281497921817073 no 2395 0.282743564945837 3458 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2053 5265679 138 µM -0.57519652292584 0.281339143731756 no 2396 0.282579197050513 3429 764595
SGTC_1382 3002-2117 298 µM -0.575998169860891 0.281077369221651 no 2397 0.282308209311427 3533 1497314
SGTC_2546 rhodinyl acetate 100 µM -0.576502078311611 0.280912880241344 no 2398 0.282137932747271 3488 6708682
SGTC_355 1311-2252 105 µM -0.576984721001281 0.280755376602382 no 2399 0.281974888504382 3412 5338538
SGTC_2328 6201408 200 µM -0.578419172329457 0.280287515878531 no 2400 0.281490576495506 3470 2890418
SGTC_2829 7992743 58.44 µM -0.578560373340175 0.280241482172456 no 2401 0.281442924679502 3444 16462845
SGTC_59 0330-0160 1.33 µM -0.578966032535309 0.280109251400634 no 2402 0.281306046486805 3494 4293482
SGTC_2451 5856223 45.7 µM -0.579544603630464 0.279920709703588 no 2403 0.28111087969598 3428 2179896
SGTC_1380 2291-0730 164 µM -0.579883879422974 0.279810176929989 no 2404 0.280996463746638 3425 2999191
SGTC_2830 7992007 71.43 µM -0.579931650004371 0.279794615436972 no 2405 0.28098035560305 3419 1952075
SGTC_1490 4089-0339 670 nM -0.580795822349615 0.279513179723947 no 2406 0.28068903551092 3474 742542
SGTC_2127 5253358 187.912 µM -0.581871827710811 0.279162948424453 no 2407 0.280326508983746 3411 20612
SGTC_1711 st032263 62.8 µM -0.582019843282044 0.279114787214245 no 2408 0.280276657489654 3446 3958979
SGTC_817 1391-0715 46 µM -0.582930750476215 0.278818485785963 no 2409 0.279969959435142 3418 1353946
SGTC_1002 4049-0206 172 µM -0.585482086001911 0.277989398809757 no 2410 0.279111804246905 3474 4662749
SGTC_2973 9094665 17.96 µM -0.588315069877123 0.277070198678953 no 2411 0.278160416138165 3536 25237061 YIL048W NEO1
SGTC_2858 9025781 8.96 µM -0.589441473833774 0.276705135356612 no 2412 0.277782580938519 3540 4894980 YPL153C RAD53
SGTC_478 N-arachidonylglycine 10 µM -0.590715391694347 0.27629254753604 no 2413 0.277355566637414 3451 5283389
SGTC_2700 st077718 96.8 µM -0.591785494577641 0.275946203342001 no 2414 0.276997118864222 3462 904970
SGTC_1681 tripelennamine 100 µM -0.591801446703789 0.275941041969504 no 2415 0.276991777164876 3512 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1047 2043-3044 82 µM -0.592677717864336 0.275657593891727 no 2416 0.276698428122286 3456 669592
SGTC_1954 st077032 68.9 µM -0.593186465861943 0.275493094505424 no 2417 0.276528184577562 3450 698907
SGTC_2619 obliquin 87.91 µM -0.59395674130527 0.275244124353793 no 2418 0.276270523261014 3506 6708593 A bioactive alkalod. YER133W GLC7
SGTC_314 1671-0008 2.74 µM -0.59400262202042 0.275229298182323 no 2419 0.276255179630846 3450 3913060
SGTC_2531 methyl deoxycholate 70.07 µM -0.595195596289957 0.274843931343326 no 2420 0.275856366791644 3427 16667744 Haematoxylin.
SGTC_2895 9054447 58.44 µM -0.595873349844472 0.274625114938158 no 2421 0.275629918973913 3493 2697450
SGTC_1041 0206-0046 107 µM -0.595877268827473 0.274623849923182 no 2422 0.275628609847629 3454 50494
SGTC_501 nsc-95397 161 µM -0.595918502271448 0.27461054028611 no 2423 0.275614836106046 3537 262093
SGTC_2640 pentamidine 10.38 µM -0.597229892415381 0.274187406096958 no 2424 0.275176952092395 3510 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_971 1315-0384 26.7 µM -0.597595321554961 0.274069553836341 no 2425 0.275054993334253 3483 6769120
SGTC_2026 5148700 152 µM -0.598906866318225 0.273646781989017 no 2426 0.274617496195778 3467 79838
SGTC_1117 retinoic acid 1.10837 µM -0.599156842989005 0.273566239512408 no 2427 0.274534149457107 3562 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2262 9014885 67.46 µM -0.599318699044852 0.273514095753589 no 2428 0.274480190381016 3463 6457424
SGTC_2866 9034245 58.44 µM -0.599478039638398 0.273462767185243 no 2429 0.274427075014612 3497 6462273
SGTC_2179 6298986 200 µM -0.599774458202577 0.273367294221169 no 2430 0.274328278910798 3504 738374
SGTC_1921 5740136 50 µM -0.600173136273453 0.273238910697087 no 2431 0.27419542748093 3532 1774243
SGTC_3179 9107801 49.47 µM -0.600940182084795 0.272991988320944 no 2432 0.273939914343146 3497 4818259
SGTC_3209 9113616 49.47 µM -0.601226877901295 0.272899725487168 no 2433 0.273844442388047 3570 16649353
SGTC_393 acivicin 6.25 µM -0.601585747121018 0.272784258012505 no 2434 0.273724959314348 3438 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_3327 9140648 26.9345 µM -0.601751238239237 0.272731018811076 no 2435 0.273669868857426 3530 8029710
SGTC_2059 5238311 157 µM -0.603376694073747 0.27220837688013 no 2436 0.273129061408251 3473 703021
SGTC_3331 9141060 1.957 µM -0.605058036328895 0.271668289723708 no 2437 0.272570217726703 3463 4906567 YPR165W RHO1
SGTC_580 1123-0028 41 µM -0.605837186303866 0.271418189218533 no 2438 0.272311436868683 3579 1677248 YPR107C YTH1
SGTC_1296 1068-0102 11.9 µM -0.606335351794756 0.271258342480471 no 2439 0.27214604402576 3501 767053
SGTC_3071 9117417 49.47 µM -0.608094514443083 0.270694254329337 no 2440 0.271562395124995 3444 45595590 YGL055W OLE1
SGTC_1201 1889-3372 45.9 µM -0.608200939972558 0.270660147017466 no 2441 0.271527105637171 3467 5392199
SGTC_1216 1165-0504 9.65 µM -0.609839243574025 0.270135373544865 no 2442 0.270984151281714 3556 6304004
SGTC_1714 st033236 13.627 µM -0.610312938262498 0.269983736863433 no 2443 0.270827263930506 3607 2916566
SGTC_2707 st078556 66.6 µM -0.611881629096637 0.26948188000901 no 2444 0.270308038499997 3490 17250899
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.612976515598752 0.269131880298351 no 2445 0.26994593403878 3523 756377
SGTC_487 nimodipine 119 µM -0.613206871696454 0.269058271976049 no 2446 0.269869780837659 3457 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1313 1220-0047 237 µM -0.613431205074026 0.268986597874611 no 2447 0.269795629019949 3534 3528706
SGTC_499 genistein 192 µM -0.614794318903913 0.268551291668335 no 2448 0.269345280794074 3544 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2416 tofa 880 nM -0.614923625816832 0.268510016299386 no 2449 0.269302579704496 3425 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2620 irigenin 100 µM -0.61513105999265 0.268443809006406 no 2450 0.26923408570014 3567 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1618 st003135 44.5 µM -0.616496224161824 0.268008290962506 no 2451 0.268783531595669 3500 1270615
SGTC_776 4476-4378 112 µM -0.616863488834534 0.267891186035643 no 2452 0.268662385501419 3536 2892008
SGTC_2960 9079389 5.97 µM -0.617455564798321 0.267702452724253 no 2453 0.268467140837115 3541 16457355
SGTC_2783 7738165 71.43 µM -0.617505875937755 0.26768641836491 no 2454 0.268450553380913 3477 17201110
SGTC_1504 k297-0033 30 µM -0.619162432616944 0.267158737678244 no 2455 0.267904678785635 3411 4388117
SGTC_793 0488-0545 106 µM -0.620978539171729 0.266580837858033 no 2456 0.26730687181429 3467 292548
SGTC_1769 st044406 64.4 µM -0.621156459251997 0.266524256263268 no 2457 0.267248342161629 3511 670903
SGTC_3299 9121982 43.1275 µM -0.622325730156029 0.266152559525165 no 2458 0.266863852803256 3521 17594604 YPL160W CDC60
SGTC_632 0781-2353 4.65 µM -0.623536438998589 0.265767966956751 no 2459 0.266466032203725 3565 6811515 YHR007C ERG11
SGTC_3058 9093861 49.47 µM -0.625316080816391 0.265203159551102 no 2460 0.265881813908407 3598 17217477
SGTC_235 0330-0087 5 mM -0.625458974525949 0.265157835623573 no 2461 0.265834933129949 3561 46494818 YHR062C RPP1
SGTC_1224 0823-0416 294 µM -0.629823709452821 0.263775299357851 no 2462 0.264404965769544 3596 3598164
SGTC_2976 9009005 19.48 µM -0.630550441868334 0.263545463290885 no 2463 0.264167255655887 3595 2993148
SGTC_2931 9014674 55.67 µM -0.631604130145221 0.263212405911395 no 2464 0.263822793545039 3547 2996810
SGTC_2357 9067248 200 µM -0.632107632124601 0.263053331329771 no 2465 0.263658274197653 3544 9150235
SGTC_2743 auranofin 4.32 µM -0.632516357399466 0.262924236294472 no 2466 0.263524761649909 3521 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1279 0874-0590 65.2 µM -0.633308242645116 0.262674213173699 no 2467 0.263266185831888 3550 3523074
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.634120362975375 0.262417927604095 no 2468 0.263001137270236 3574 5106787 A p450 inhibitor.
SGTC_1203 3992-3522 103 µM -0.637397297036031 0.261385108500506 no 2469 0.261933044283587 3727 5322312
SGTC_2754 granisetron 64.02 µM -0.638237603427155 0.261120598724556 no 2470 0.261659511227955 3588 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2065 5221596 34.26 µM -0.639889091200576 0.260601148274391 no 2471 0.26112235323779 3572 788581
SGTC_594 1487-1584 10.8 µM -0.640376438931667 0.260447962143002 no 2472 0.260963948343426 3541 5013332
SGTC_1892 st058411 7.36 µM -0.641523829518461 0.260087490492418 no 2473 0.260591201872703 3557 3934738
SGTC_1437 4092-1038 11.6 µM -0.641800502681468 0.260000607566404 no 2474 0.260501361614019 3573 3977136
SGTC_1356 1502-0781 85.8 µM -0.642381566509132 0.259818186398775 no 2475 0.260312732709029 3563 567702
SGTC_766 1391-0721 126 µM -0.64315337065944 0.259575985713241 no 2476 0.260062293235316 3598 1020919 YIL115C NUP159
SGTC_3105 9121040 49.47 µM -0.64445359875124 0.259168223523408 no 2477 0.259640668803666 3467 41448907
SGTC_1228 0124-0032 52.5 µM -0.644713075382135 0.259086889175956 no 2478 0.259556570678809 3599 X1228
SGTC_3007 9078383 71.4286 µM -0.64768796174421 0.258155338973799 no 2479 0.258593395970178 3574 6496995
SGTC_3 0833-0587 95.581 µM -0.649249127439009 0.257667174241323 no 2480 0.258088681056379 3537 5382644
SGTC_2066 5222451 176 µM -0.649264448306813 0.257662385897502 no 2481 0.258083730449918 3609 2281147
SGTC_2391 6285546 200 µM -0.65119952121511 0.25705797492297 no 2482 0.257458849692628 3554 846083
SGTC_2285 7945142 200 µM -0.652129490379686 0.25676776597734 no 2483 0.257158820565241 3604 2970608
SGTC_1014 4130-3005 69.3 µM -0.653607364941184 0.256306927161172 no 2484 0.256682399025447 3621 743608
SGTC_1008 4106-0037 6 µM -0.65530576962099 0.255777854360415 no 2485 0.256135453415198 3587 2905394
SGTC_281 1672-3440 14.9 µM -0.656727023188282 0.255335555913865 no 2486 0.255678227680613 3603 6833000
SGTC_2964 9083345 53.42 µM -0.657141418088315 0.255206670272046 no 2487 0.255544994669097 3567 17741579
SGTC_1805 st050013 60.3 µM -0.657816522265807 0.254996771366449 no 2488 0.255328018142811 3569 4037144
SGTC_1306 1185-0270 9.02 µM -0.658769758849647 0.254700551258595 no 2489 0.255021814726464 3610 1548076
SGTC_1106 tegaserod maleate 11.7 µM -0.661348111421021 0.253900226968352 no 2490 0.25419454702272 3616 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2900 5328528 85.29 µM -0.661485728254415 0.253857547642103 no 2491 0.254150432080578 3629 795359
SGTC_2811 7967822 32.47 µM -0.66227406324792 0.2536131326554 no 2492 0.253897798012061 3609 2232244
SGTC_247 mechlorethamine 29.705 µM -0.665004263268543 0.252767619072769 no 2493 0.253023883134676 3548 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_26 0302-0163 425.158 µM -0.667035243929573 0.252139610245952 no 2494 0.252374810742472 3628 3100915
SGTC_1298 1079-1278 263 µM -0.667137744616583 0.25210793736962 no 2495 0.252342076268509 3651 2840950
SGTC_2526 patulin 37.61 µM -0.667918920995958 0.251866621582692 no 2496 0.25209267443688 3653 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2863 9028737 58.44 µM -0.668927854693109 0.251555129055264 no 2497 0.251770750325968 3612 6460917
SGTC_1522 st012842 45.6 µM -0.669081598642214 0.251507680887839 no 2498 0.25172171375556 3558 3491067 YOR116C RPO31
SGTC_1604 st002052 72.4 µM -0.670052080247312 0.251208281859178 no 2499 0.251412295475932 3662 6254834 YHR062C RPP1
SGTC_2050 5263056 171 µM -0.670781376009691 0.250983414121449 no 2500 0.251179906748364 3631 763468 YGL055W OLE1
SGTC_106 0092-0003 11.579 µM -0.670944933783327 0.250932998088475 no 2501 0.251127804970962 3584 1072148
SGTC_3287 9117173 37.0625 µM -0.671191568150224 0.250856984162308 no 2502 0.251049249727895 3599 2789709
SGTC_2608 thymoquinone 42.66 µM -0.671461075428099 0.250773934631921 no 2503 0.250963424126628 3560 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_2634 4'-methoxyflavone 100 µM -0.672025400371312 0.250600083261535 no 2504 0.250783763044906 3615 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2644 guaiazulene 100 µM -0.672057745876442 0.250590120529083 no 2505 0.250773467445157 3640 3515 A coloring agent.
SGTC_2239 6685329 187.64 µM -0.673686453789252 0.250088733938057 no 2506 0.25025533791829 3637 805680
SGTC_1128 3448-9350 235 µM -0.674265387518239 0.249910641440817 no 2507 0.250071302597192 3620 619386
SGTC_578 3460-0051 92 µM -0.675988729119506 0.249380903078388 no 2508 0.249523900513306 3696 2876744
SGTC_585 0kpi-0023 191 µM -0.676127299657947 0.24933833379066 no 2509 0.249479912650711 3592 64601
SGTC_1018 4259-0013 28.1 µM -0.677828484662845 0.248816039594194 no 2510 0.248940224098961 3635 6801262
SGTC_640 3381-0960 37.1 µM -0.678482360257896 0.24861544317526 no 2511 0.248732952256483 3678 1745025
SGTC_2472 5377652 49.4 µM -0.679224304236575 0.248387933447593 no 2512 0.24849787498593 3646 1610903
SGTC_2799 7812892 81.82 µM -0.680934557313813 0.247863924389651 no 2513 0.247956450273185 3634 20205235
SGTC_2744 captopril 92.04 µM -0.681411815718306 0.247717801278601 no 2514 0.247805474243653 3617 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_588 3970-1144 52.9 µM -0.68191490585532 0.247563819034004 no 2515 0.247646379746832 3577 1888707
SGTC_354 2783-3500 4.88 µM -0.681935171606322 0.247557617308903 no 2516 0.247639972158877 3626 6740761
SGTC_2012 4023501 200 µM -0.68226911056455 0.247455437262249 no 2517 0.247534400704603 3626 3477460
SGTC_516 3992-2719 87.3 µM -0.683631160586732 0.24703890500819 no 2518 0.247104051408804 3617 5350887 YDR037W KRS1
SGTC_1552 6-methylflavone 10.6 µM -0.683789470071217 0.246990516294855 no 2519 0.247054058386173 3619 689013
SGTC_1944 st076371 56.9 µM -0.683996100228966 0.246927365564937 no 2520 0.246988814175772 3642 24208455
SGTC_864 0469-0573 172 µM -0.684481093480573 0.246779174888451 no 2521 0.246835712046621 3618 689425
SGTC_246 cycloheximide 667 µM -0.684576405286813 0.246750057770876 no 2522 0.246805630095836 3541 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_597 k018-0003 82.8 µM -0.685368345418025 0.246508196526532 no 2523 0.246555756875025 3736 6786234
SGTC_1638 st008370 60.6 µM -0.685445579308821 0.246484615829783 no 2524 0.246531395266422 3658 24207134
SGTC_877 0771-0151 33.1 µM -0.686310260655322 0.246220697825253 no 2525 0.24625873999826 3669 6166523
SGTC_63 0099-0242 26.702 µM -0.686782358284351 0.246076668179975 no 2526 0.246109944279573 3672 3898502 YLR359W ADE13
SGTC_1404 3909-7820 48.3 µM -0.687092013231402 0.245982221819855 no 2527 0.24601237343554 3629 23741373
SGTC_2914 7968218 45.32 µM -0.688190497545243 0.245647335361436 no 2528 0.245666413559081 3613 2977111
SGTC_1362 1611-0397 101 µM -0.689001878165515 0.245400133305364 no 2529 0.24541104282114 3650 27816
SGTC_1978 st071761 42 µM -0.690564568995868 0.244924407683691 no 2530 0.244919609890741 3646 5147680
SGTC_185 k048-0037 25.491 µM -0.691277283746796 0.244707602807498 no 2531 0.244695652264807 3662 6827589
SGTC_1531 st059297 52.4 µM -0.691776383631004 0.244555840227416 no 2532 0.244538884888814 3672 7566702
SGTC_1974 st069448 26.9 µM -0.692840442269865 0.24423245852028 no 2533 0.244204844552529 3633 6323587 YNR016C ACC1
SGTC_1271 0832-2808 169 µM -0.693585972858966 0.244006019184309 no 2534 0.243970946500762 3682 3663794
SGTC_348 k064-0012 10.7 µM -0.695809509441067 0.243331339535651 no 2535 0.24327406655845 3610 5066323
SGTC_670 4204-0025 119 µM -0.695920538292198 0.243297676901569 no 2536 0.243239297165444 3678 719039
SGTC_551 k048-0028 34.9 µM -0.697205098641332 0.242908396480284 no 2537 0.242837224292006 3672 6836383
SGTC_837 0091-0265 12.5 µM -0.698872641320147 0.242403558028503 no 2538 0.242315813266448 3659 759367
SGTC_651 3253-0966 34.4 µM -0.699098161682323 0.242335326767856 no 2539 0.242245343651539 3695 781462
SGTC_2237 6667747 47.222 µM -0.700245909927794 0.241988236473158 no 2540 0.241886872490144 3624 729940 YDL015C TSC13
SGTC_2814 7977482 42.97 µM -0.701877217079951 0.241495377562371 no 2541 0.241377869109247 3726 6456762
SGTC_1091 telmisartan 47.6 µM -0.702549276948425 0.241292490053512 no 2542 0.24116834115541 3742 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_3133 9127736 49.47 µM -0.703551671095355 0.240990050428785 no 2543 0.240856008749065 3677 27243420
SGTC_1166 k206-0078 225 µM -0.703758865307895 0.240927562077461 no 2544 0.240791477300741 3694 5404595
SGTC_2515 chrysin 20.77 µM -0.707548491603155 0.239786193071589 no 2545 0.239612844620784 3698 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_188 3229-0966 278.469 µM -0.708579233225687 0.239476262859242 no 2546 0.239292813554858 3756 5722370
SGTC_3271 9137798 49.47 µM -0.708883417151315 0.239384840642434 no 2547 0.239198413282698 3621 6498326
SGTC_1965 Pectolinarigenin 58.4 µM -0.709140612009734 0.239307555824253 no 2548 0.239118611451736 3694 5320438 An anti-inflammatory.
SGTC_2474 5321570 43.32 µM -0.711188055301704 0.238692803338203 no 2549 0.238483854730745 3724 2841384
SGTC_31 0508-1974 57.237 µM -0.711799693331094 0.238509324505104 no 2550 0.238294411322102 3647 6810525
SGTC_918 glabranin 770.725 nM -0.712210715219052 0.238386069778274 no 2551 0.238167151323564 3724 124049 Also referred to as licorice root.
SGTC_2699 st077704 54.6 µM -0.712719128780522 0.238233658101674 no 2552 0.238009788590412 3715 645852
SGTC_2549 cedrol 20.94 µM -0.713216102297759 0.238084727519279 no 2553 0.237856021848573 3639 6708665 A sedative which affects the nervous system.
SGTC_2477 5967686 25.23 µM -0.713272840619165 0.238067727703693 no 2554 0.237838470119395 3711 776118
SGTC_3235 9132602 49.47 µM -0.713824821869812 0.237902378974543 no 2555 0.237667754424011 3712 4912240
SGTC_987 1497-1013 404 µM -0.713930634326868 0.237870689520758 no 2556 0.23763503663242 3684 1676435
SGTC_745 0469-0705 296 µM -0.714769037795 0.237619680442747 no 2557 0.237375885073928 3771 3486736
SGTC_411 enrofloxacin 100 µM -0.719925660544091 0.236079043059568 no 2558 0.235785383886912 3764 71188 A bacterial gyrase inhibitor.
SGTC_3038 9091290 49.47 µM -0.720024757409194 0.236049490014084 no 2559 0.235754876247554 3718 25236843
SGTC_2739 tacrine 100.86 µM -0.720155799747566 0.236010413197755 no 2560 0.235714537320828 3705 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_842 0271-0008 11.1 µM -0.720556256602197 0.235891019085581 no 2561 0.235591287779448 3762 1221709
SGTC_891 0929-0073 133 µM -0.721017471577574 0.235753551521426 no 2562 0.235449382630516 3745 5603632
SGTC_857 0438-0306 1.35 µM -0.721058031206781 0.235741464622815 no 2563 0.235436905630326 3746 4686136
SGTC_366 0181-0206 4.31 µM -0.722837285210719 0.235211577685545 no 2564 0.234889928687449 3707 274874
SGTC_910 3454-3003 490 µM -0.723900432289424 0.234895271660103 no 2565 0.234563432287615 3638 820824
SGTC_2921 7974240 10.71 µM -0.724223080365737 0.234799324374207 no 2566 0.234464395543549 3735 2979074 YDR527W RBA50
SGTC_2977 9011197 71.43 µM -0.724446477439368 0.234732904493127 no 2567 0.234395837425984 3720 2704722
SGTC_628 1636-0253 16 µM -0.72506359361701 0.234549478988421 no 2568 0.234206508882908 3717 4456143
SGTC_1244 0416-0015 52.5 µM -0.727121762471572 0.233938302775714 no 2569 0.23357568415467 3725 96201
SGTC_1205 4161-2785 76 µM -0.727612307427272 0.233792765057488 no 2570 0.233425472251061 3766 3498106
SGTC_2367 9070478 135.38 µM -0.72920159265199 0.233321591539718 no 2571 0.232939178569279 3696 572802
SGTC_3303 9125618 40.5795 µM -0.729324911969248 0.233285053249457 no 2572 0.232901468540005 3748 22695467
SGTC_2898 9056270 58.44 µM -0.73037453590436 0.232974188658352 no 2573 0.232580639512211 3669 19154699
SGTC_1410 3909-8106 77.9 µM -0.731512211179152 0.232637506103621 no 2574 0.232233174296716 3737 1039210
SGTC_1357 1503-1303 39.5 µM -0.732916995851262 0.232222148879618 no 2575 0.231804528200642 3726 292895
SGTC_3142 9086498 49.47 µM -0.732927658840837 0.232218997697923 no 2576 0.231801276257443 3699 25236367
SGTC_2104 5389443 200 µM -0.73294180748934 0.232214816453052 no 2577 0.231796961315315 3765 2244536
SGTC_3312 9133330 71.43 µM -0.7340285179452 0.231893794207436 no 2578 0.231465678749692 3770 17617324
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.734429693115535 0.231775346612024 no 2579 0.23134344765892 3756 688664
SGTC_2312 7706453 155.7 µM -0.735713030713637 0.231396665647009 no 2580 0.230952678912551 3779 976098
SGTC_1788 fluconazole 20 µM -0.736409899186463 0.231191181744734 no 2581 0.230740641039394 3754 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3044 9093193 49.47 µM -0.737147353470324 0.230973841325138 no 2582 0.230516372497256 3715 25236277
SGTC_1214 0358-0031 63.7 µM -0.737161310845324 0.230969728947581 no 2583 0.230512129070015 3813 4301366
SGTC_427 1354-0053 47.3 µM -0.73771091357592 0.230807827419487 no 2584 0.230345069382223 3814 6813657
SGTC_3168 9103419 49.47 µM -0.738378863877091 0.230611148511763 no 2585 0.230142127407218 3675 16649256
SGTC_3257 9139206 32.98 µM -0.739390543245055 0.230313436511176 no 2586 0.229834941503334 3725 4910041
SGTC_386 1509-0011 3.07 µM -0.73942715608354 0.230302666297413 no 2587 0.229823828702186 3781 3107280
SGTC_2890 9046729 58.44 µM -0.741010883846658 0.229837058775 no 2588 0.229343420573043 3672 903329
SGTC_1732 st034308 51.822 µM -0.74150476461432 0.229691968336195 no 2589 0.229193721962724 3648 830119
SGTC_3165 9101544 49.47 µM -0.742620141573439 0.229364485901729 no 2590 0.228855845339756 3743 5002184
SGTC_2296 7971656 126.45 µM -0.746525423458406 0.228219932838147 no 2591 0.227675039836194 3805 666570
SGTC_2342 7990637 118.86 µM -0.746770401985153 0.22814824215102 no 2592 0.227601082345824 3823 2033102 YER133W GLC7
SGTC_1706 st031321 9.9705 µM -0.748342318703868 0.227688536759429 no 2593 0.227126852477175 3763 6103185
SGTC_1709 st033179 39.1045 µM -0.748627669759217 0.227605142097723 no 2594 0.227040824998265 3722 573381
SGTC_554 4483-2211 187 µM -0.749318187442206 0.227403407510818 no 2595 0.226832724148743 3773 747107
SGTC_1270 0831-1170 17.3 µM -0.749325827949524 0.227401175901883 no 2596 0.226830422136255 3737 6764716
SGTC_3116 9124943 49.47 µM -0.7495535487564 0.22733466977948 no 2597 0.226761818064365 3703 41905195 YPL160W CDC60
SGTC_1877 wortmannin 25 µM -0.751863780979935 0.226660583681603 no 2598 0.226066490570956 3749 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.752833491572281 0.226377975258099 no 2599 0.225774989149213 3780 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_779 1360-0071 233 µM -0.75322241375023 0.226264685334302 no 2600 0.22565813633061 3822 7566
SGTC_2598 perillyl alcohol 100 µM -0.755061241507236 0.225729483423087 no 2601 0.225106118682524 3778 10819 An apoptosis inducer.
SGTC_708 3448-5400 146 µM -0.758408013893865 0.224757225408094 no 2602 0.224103380907951 3739 3462195
SGTC_2963 9082507 9 µM -0.759530808051246 0.224431579538166 no 2603 0.223767545963676 3800 16459611
SGTC_150 3970-0969 77.2 µM -0.761907966349012 0.223743012688458 no 2604 0.223057467528992 3871 6615640
SGTC_1006 4099-6547 255 µM -0.762773494809229 0.223492602576093 no 2605 0.222799245442236 3804 3146833
SGTC_581 0958-0271 211 µM -0.763058838730971 0.223410083338938 no 2606 0.222714153178604 3800 4591145
SGTC_2295 7971645 200 µM -0.763436941965882 0.223300765540795 no 2607 0.222601427746246 3811 2978226 YKL099C UTP11
SGTC_184 1494-0393 24.714 µM -0.764290269519374 0.223054162059295 no 2608 0.222347141362839 3762 3090647
SGTC_1010 4112-3296 15.2 µM -0.76464381431405 0.222952036458983 no 2609 0.222241835749008 3826 704384
SGTC_3089 9117425 49.47 µM -0.764934500083182 0.222868088388033 no 2610 0.222155274426765 3708 9401657
SGTC_3081 9117243 49.47 µM -0.767674769858296 0.222077602719831 no 2611 0.221340214538184 3802 45595589
SGTC_692 k241-0027 77.8 µM -0.773437490278614 0.22042046334623 no 2612 0.219631754865632 3814 3600480
SGTC_1368 1852-0141 284 µM -0.773793521537561 0.220318315279637 no 2613 0.219526452116942 3773 2838987
SGTC_1055 3448-0672 86 µM -0.774199937600434 0.2202017446093 no 2614 0.219406282596577 3806 748378
SGTC_2636 apigenin dimethyl ether 100 µM -0.775166876674818 0.219924543625307 no 2615 0.219120529039942 3792 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1183 1254-0324 198 µM -0.775185082533349 0.219919326312068 no 2616 0.219115150827781 3860 5799357
SGTC_2398 5228213 48.84 µM -0.775701910268969 0.219771246904973 no 2617 0.218962505856883 3788 80771 YMR134W ERG29
SGTC_1602 st001878 87.6 µM -0.776672095786798 0.219493427876705 no 2618 0.218676126994432 3813 595405 YLR310C CDC25
SGTC_2828 7998861 71.43 µM -0.777099944820912 0.219370974612596 no 2619 0.218549903269287 3691 2988188
SGTC_308 4092-1169 104 µM -0.777491777924847 0.219258863795397 no 2620 0.218434341749146 3749 2268590 YDL196W YDL196W
SGTC_1485 3909-9022 254 µM -0.778132506994901 0.219075610135594 no 2621 0.218245450339934 3828 714516
SGTC_871 0574-0004 149 µM -0.78119764530434 0.218200175326959 no 2622 0.217343129215408 3791 9551173
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.781774621305034 0.218035610829346 no 2623 0.217173519187994 3780 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2709 st078560 56 µM -0.781975009292969 0.217978473119269 no 2624 0.217114630278464 3784 17250903
SGTC_2685 mycophenolic acid 18.85 µM -0.782526317588863 0.217821320160898 no 2625 0.2169526624728 3799 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_342 k048-0088 23.3 µM -0.782759184006672 0.217754960156597 no 2626 0.216884270079918 3798 6820570
SGTC_609 0986-0026 86.3 µM -0.786127909463938 0.216796279112757 no 2627 0.21589627749248 3779 2848610
SGTC_169 k015-0017 16.025 µM -0.786402498921457 0.216718243414725 no 2628 0.215815859971073 3808 1840002
SGTC_1663 st014140 55.4 µM -0.786585303295291 0.216666301168048 no 2629 0.215762332675381 3873 4207120
SGTC_852 0418-0143 439 µM -0.787303033238929 0.21646243419771 no 2630 0.215552247242366 3858 5369229
SGTC_537 1334-0398 209 µM -0.787850678957313 0.216306953341923 no 2631 0.215392026678758 3784 5846986
SGTC_1831 st055328 12 µM -0.78820552851437 0.216206243333731 no 2632 0.215288247928112 3787 1103068
SGTC_1004 4084-0029 199 µM -0.788395540370596 0.216152327149063 no 2633 0.215232689286346 3850 716894 YLR208W SEC13
SGTC_1893 st059353 36.1 µM -0.789667421411218 0.215791629306728 no 2634 0.21486101112563 3846 3112488
SGTC_154 3389-1638 511.116 µM -0.789862675376755 0.215736287357765 no 2635 0.214803985647716 3769 5238686
SGTC_2331 7980721 200 µM -0.790194951829367 0.215642127257472 no 2636 0.214706961876465 3788 2981221
SGTC_1661 st013063 9.66 µM -0.790629489672427 0.215519024412282 no 2637 0.214580116509576 3852 721395
SGTC_3084 9116877 49.47 µM -0.790912306685052 0.215438925376987 no 2638 0.214497583176514 3707 27241325
SGTC_2181 6316240 54.2555 µM -0.791216738989725 0.215352723791532 no 2639 0.214408762570588 3827 12779990
SGTC_6 0844-0013 19.835 µM -0.791352691903274 0.215314234484167 no 2640 0.214369104109571 3922 1584900
SGTC_1063 disulfiram 1.84 µM -0.791587845174462 0.215247670222612 no 2641 0.214300518249484 3806 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2688 kanamycin b 96.69 µM -0.793412126162536 0.214731681325655 no 2642 0.213768874027037 3916 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1423 4048-0112 5.59 µM -0.796274744730707 0.213923454251719 no 2643 0.212936180744742 3854 X1423
SGTC_2778 tioconazole 65.09 nM -0.796962740676836 0.213729470904017 no 2644 0.212736335419283 3774 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2255 7941087 197.44 µM -0.797868509643398 0.213474241837786 no 2645 0.212473399622297 3828 935561
SGTC_1866 st057638 64 µM -0.798748583571488 0.213226423393144 no 2646 0.212218104785384 3804 688802
SGTC_3126 9127922 49.47 µM -0.799359161463676 0.213054590472316 no 2647 0.212041091676994 3827 45595682
SGTC_874 0599-0792 117 µM -0.799814160095782 0.212926594256821 no 2648 0.211909238835672 3816 765305
SGTC_2746 daunorubicin 9.88 µM -0.800210165219216 0.212815230109613 no 2649 0.21179452061307 3719 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2257 7960413 200 µM -0.801399655410522 0.212480927428298 no 2650 0.211450157288151 3819 2974689 YIL048W NEO1
SGTC_1231 0242-0792 125 µM -0.801729273299447 0.212388343614067 no 2651 0.211354789321652 3837 3707635
SGTC_1878 temozolomide 1 mM -0.802537455399136 0.212161439384671 no 2652 0.211121065564261 3744 5394 DNA alkylating agent.
SGTC_2771 fluoxetine 41.05 µM -0.802786374957371 0.212091581587842 no 2653 0.211049109322869 3796 3386 A selective serotonin reuptake inhibitor.
SGTC_2164 5685496 200 µM -0.805217338896175 0.211410053374521 no 2654 0.210347136262973 3780 759046
SGTC_1770 st043884 66.3 µM -0.805342377729011 0.211375033070746 no 2655 0.210311066749976 3833 670149
SGTC_2928 9011484 9.79 µM -0.805476504450199 0.211337471250293 no 2656 0.210272379723285 3870 2994751
SGTC_1433 4060-0023 7.6 µM -0.805747350277888 0.211261633539375 no 2657 0.21019427067272 3841 3840627
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.808793967753379 0.210409669714964 no 2658 0.209316833281829 3847 689007
SGTC_446 go6976 132 µM -0.809485889361431 0.210216460430193 no 2659 0.209117858038033 3833 3501 A protein kinase C inhibitor.
SGTC_2563 tomatine 8.54 µM -0.809591292222217 0.210187037325928 no 2660 0.20908755721486 3763 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1064 honokiol 6.76 µM -0.809743469052849 0.210144561581632 no 2661 0.209043814545691 3851 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_473 2-arachidonoylglycerol 10 µM -0.811059667750566 0.209777393378861 no 2662 0.208665703026062 3726 5282280 An endocannabinoid.
SGTC_963 1269-2853 151 µM -0.814413857079148 0.208843412092824 no 2663 0.207703951455594 3854 3668223
SGTC_2642 cholecalciferol 100 µM -0.815700863329185 0.208485693822593 no 2664 0.20733562256728 3821 9821465 A vitamin D precursor, similar to steriods.
SGTC_2207 7258803 200 µM -0.816230807355166 0.208338503068265 no 2665 0.207184069971696 3806 3666799
SGTC_2130 NSC 7 2.4545 µM -0.817523764905446 0.207979644357738 no 2666 0.206814586968026 3913 21448
SGTC_2420 aureobasidin a 50 nM -0.81955132999475 0.207417631692313 no 2667 0.20623596437433 3986 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_807 1315-0151 48 µM -0.820147078738146 0.207252669282635 no 2668 0.20606613332597 3836 4011080
SGTC_1435 4092-0789 56.7 µM -0.820734732162649 0.207090024497802 no 2669 0.205898691299213 3844 2248285
SGTC_3228 9131799 49.47 µM -0.821136110021995 0.206978978597607 no 2670 0.205784371787994 3869 17015818
SGTC_710 3448-4187 58 µM -0.821246794576475 0.206948362614449 no 2671 0.205752853496173 3855 3946412
SGTC_3073 9114972 49.47 µM -0.821495517090325 0.206879574317732 no 2672 0.205682038268976 3815 41905075
SGTC_781 4335-2806 94.4 µM -0.821876555905569 0.206774218025943 no 2673 0.205573578561888 3982 845254
SGTC_1406 3909-7906 11.9 µM -0.823744691744318 0.206258142892298 no 2674 0.205042319863548 3870 X1406
SGTC_1704 st028805 70.8 µM -0.823767273310158 0.206251909376895 no 2675 0.205035903135037 3889 2876101
SGTC_2740 felodipine 17.08 µM -0.825082402875669 0.205889067848978 no 2676 0.204662404722046 3807 3333 L-type calcium channel blocker
SGTC_1574 spiramycin 23.7 µM -0.825125996349492 0.205877046987359 no 2677 0.204650031056688 3841 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_496 calpeptin 138 µM -0.826849340565295 0.205402170011098 no 2678 0.20416122998182 3860 73364 A calpain inhibitor.
SGTC_913 3487-1245 167 µM -0.827481292907977 0.205228195211544 no 2679 0.203982160443061 3841 4016153
SGTC_3341 9147222 25.867 µM -0.830136177093431 0.204498269716386 no 2680 0.203230897490783 3892 1939759
SGTC_272 doxorubicin 8.13 µM -0.830238322483404 0.204470217084812 no 2681 0.203202026040652 3854 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1897 st060201 15 µM -0.830464067212932 0.204408227955143 no 2682 0.203138227854593 3920 611878
SGTC_801 0866-0028 10.1 µM -0.831245226318172 0.204193809303292 no 2683 0.202917555159536 3869 6849771
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.831323772036316 0.204172256875157 no 2684 0.20289537439703 3850 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2870 9038528 12.99 µM -0.83223162635118 0.20392324596922 no 2685 0.202639107797933 3924 6463316
SGTC_1113 artemisinin 1.17947 µM -0.832861904555966 0.203750476537579 no 2686 0.202461308438526 3895 2240 An anti-malaria and mitochondrial poison.
SGTC_869 0564-0080 44.1 µM -0.833734087642296 0.203511541052083 no 2687 0.202215422430823 3897 6843321
SGTC_268 camptothecin 39.6153 µM -0.833993136902565 0.203440606435899 no 2688 0.202142425642711 3863 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.83429162363412 0.203358891077079 no 2689 0.202058335429292 3899 6728940
SGTC_2400 5203494 178.7 µM -0.834356872385027 0.203341030831309 no 2690 0.202039956223709 3811 6777674
SGTC_671 0560-0003 407 µM -0.835005723695363 0.203163474632752 no 2691 0.201857242859063 3793 3238678
SGTC_2046 4110841 106 µM -0.835479095820149 0.203033996192879 no 2692 0.201724006013954 3907 44119630 YMR134W ERG29
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.835818050967408 0.202941314246472 no 2693 0.201628634972288 3937 65057 A dermal irritant. YDR527W RBA50
SGTC_1345 1488-0192 31.4 µM -0.836985788723317 0.202622208283226 no 2694 0.201300278121044 3883 658348
SGTC_1671 st016596 74.5 µM -0.837717232509915 0.202422480570222 no 2695 0.201094766402939 3933 2829167
SGTC_1474 0330-0125 5.35 µM -0.838987426096755 0.202075921925929 no 2696 0.200738182796967 3883 X1474
SGTC_1726 st035556 14.5795 µM -0.840665532583678 0.201618613450674 no 2697 0.200267667476708 4028 5919439
SGTC_2125 5246583 200 µM -0.842462922192113 0.201129486850732 no 2698 0.199764442707844 3866 835267
SGTC_2071 5230951 39.92 µM -0.843375177065506 0.200881505913551 no 2699 0.199509325108662 3927 1799272
SGTC_3151 9099821 49.47 µM -0.844942778462106 0.200455808933092 no 2700 0.199071394178284 3852 17174189
SGTC_1033 k072-0102 21.3 µM -0.845529072298109 0.200296734621211 no 2701 0.198907753887758 3859 5965931
SGTC_1101 ebselen 5.29 µM -0.845870132738517 0.200204232385534 no 2702 0.198812597924616 3935 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2926 9010726 65.15 µM -0.846623732963196 0.19999993237922 no 2703 0.198602440572526 3939 2994293
SGTC_2108 5365811 200 µM -0.847164296033165 0.199853463691416 no 2704 0.198451775690532 3943 780283
SGTC_1487 3970-0795 2.82 µM -0.847525324825862 0.199755676795228 no 2705 0.198351188736798 3943 3765103
SGTC_291 SEC14.278 35.5 µM -0.848393607856201 0.199520614814717 no 2706 0.198109400675417 3906 1068044
SGTC_359 0081-0058 15.9 µM -0.851248622177091 0.198748878554998 no 2707 0.197315629246557 3913 3494159
SGTC_750 4073-0104 132 µM -0.852095476525905 0.198520312701975 no 2708 0.197080551208144 3725 22330957
SGTC_1626 st003712 1.76 µM -0.852993977079524 0.19827798099208 no 2709 0.196831322115467 3901 24207035
SGTC_134 0269-0018 6.916 µM -0.85513971309231 0.197699984160976 no 2710 0.196236903251551 3873 4378915
SGTC_2443 5493264 126.67 µM -0.855628306206545 0.19756851432143 no 2711 0.196101703864762 3937 5340055
SGTC_3226 9131256 49.47 µM -0.856429755426321 0.197352976153889 no 2712 0.195880055934695 3808 17178073
SGTC_2991 9074669 71.4286 µM -0.859193665412368 0.19661075419307 no 2713 0.195116838827286 3892 17333109
SGTC_1115 galangin 695.678 nM -0.859214722683717 0.196605105960189 no 2714 0.195111031087487 3938 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1475 4092-1048 11.7 µM -0.859755499853328 0.19646008592822 no 2715 0.194961917038403 3944 2881759
SGTC_3129 9127257 49.47 µM -0.860016475255094 0.19639012343942 no 2716 0.194889980403047 3913 837894
SGTC_2267 7931562 200 µM -0.861185994010977 0.196076783453745 no 2717 0.194567806383511 3810 934880
SGTC_2986 9022445 71.43 µM -0.861473928831621 0.195999685877977 no 2718 0.194488537080676 3918 6459286
SGTC_981 1488-1094 54.9 µM -0.861983762958778 0.195863217547496 no 2719 0.194348226472623 3891 3449522
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.862496372330945 0.195726064508268 no 2720 0.194207214246853 3902 15053
SGTC_1191 1487-1166 10.6 µM -0.862775384246422 0.195651436981775 no 2721 0.194130487863879 3969 3955771
SGTC_146 3448-8650 53.125 µM -0.862885982229659 0.195621860037758 no 2722 0.194100079280186 3892 2891488 YIL048W NEO1
SGTC_566 0958-0068 16.5 µM -0.863400328691966 0.195484345312897 no 2723 0.193958699393375 3830 6815365
SGTC_3021 9087658 49.47 µM -0.865401584844234 0.194949851991789 no 2724 0.193409205722341 3867 25237042
SGTC_2671 danthron 100 µM -0.865826799800399 0.194836400609077 no 2725 0.19329257504711 3909 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2435 5706476 10.6 µM -0.866198000909178 0.194737393468411 no 2726 0.19319079473227 3934 5725375
SGTC_1526 st051518 75 µM -0.866438061771109 0.194673380488858 no 2727 0.193124989425633 3937 673993
SGTC_2407 paclitaxel 400 µM -0.868172029212702 0.194211392950541 no 2728 0.192650082045667 4097 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_250 brefeldin a 552.239 µM -0.870931993685527 0.193477423798034 no 2729 0.191895643272866 3800 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2306 7482397 179.52 µM -0.872099847190895 0.193167361680897 no 2730 0.191576954757347 3939 891448
SGTC_762 1165-0429 115 µM -0.87230467727829 0.193113011099119 no 2731 0.191521093343724 3903 5967793
SGTC_1630 st005209 31.3 µM -0.872617430747317 0.193030041631022 no 2732 0.191435818238543 3867 3367314
SGTC_778 3456-2434 196 µM -0.874106207193008 0.192635386916922 no 2733 0.191030208729792 3941 5539063
SGTC_683 panaxydol 45 µM -0.874273650039552 0.192591030929548 no 2734 0.190984622780966 3919 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1343 1487-0095 224 µM -0.877015867757744 0.191865499822497 no 2735 0.190239009720433 3933 4560101 YGL055W OLE1
SGTC_3204 9114183 49.47 µM -0.878221908477685 0.19154693817922 no 2736 0.189911652452275 3952 17027248
SGTC_266 formosanin C 406 nM -0.878412257975934 0.19149668919303 no 2737 0.189860017290819 3851 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_465 cgp-37157 41 µM -0.880587758068666 0.190922968444787 no 2738 0.189270493465762 3897 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1149 3909-7961 23.3 µM -0.880801379043355 0.190866689439278 no 2739 0.189212666609834 3969 735261
SGTC_1932 st074806 40.9 µM -0.881602065164611 0.190655837165293 no 2740 0.188996018974169 4030 17251235
SGTC_2390 9097792 176.6 µM -0.881707060126869 0.190628198452743 no 2741 0.188967621038543 3947 4497149
SGTC_911 3456-4043 236 µM -0.881987265282557 0.190554449719049 no 2742 0.188891846957863 4000 914281
SGTC_244 nsc-207895 1.295 µM -0.882022992714251 0.190545047679349 no 2743 0.188882186763856 3757 42640
SGTC_3289 9119912 71.43 µM -0.884194147637381 0.189974220676197 no 2744 0.188295708516912 3983 17014829
SGTC_231 b-estradiol 524 µM -0.884262646210673 0.189956228564974 no 2745 0.188277223796725 3903 450 A steroid.
SGTC_2907 7721985 69.9 µM -0.884810141238271 0.189812458964016 no 2746 0.188129519463399 3989 3267881
SGTC_1129 3453-1384 223 µM -0.885559547498053 0.18961577693933 no 2747 0.187927459076704 4088 1084452
SGTC_2107 5363541 170.161 µM -0.886740629739208 0.189306055963623 no 2748 0.187609279186536 3940 244052
SGTC_3190 9110366 49.47 µM -0.886931793163044 0.189255955542088 no 2749 0.187557811667113 3957 17123768
SGTC_576 1073-0113 22.7 µM -0.88874594126865 0.188780907073825 no 2750 0.187069817338593 4093 5439563
SGTC_2725 haloperidol 53.21 µM -0.889845401952398 0.188493362906166 no 2751 0.186774451974739 3902 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2909 7941780 10.49 µM -0.893565454095236 0.187522454722206 no 2752 0.185777218392569 3917 1243215
SGTC_3076 9116187 49.47 µM -0.894458892623937 0.187289734429171 no 2753 0.185538207264699 3955 27241210
SGTC_178 4092-0806 87.505 µM -0.894645287046409 0.187241205469444 no 2754 0.185488367421658 3876 2169044
SGTC_1834 st055981 52.8 µM -0.894969313068152 0.187156861766323 no 2755 0.185401746165259 4003 471719 YDL150W RPC53
SGTC_696 1560-0013 611 µM -0.896285226490505 0.186814572138009 no 2756 0.18505022368284 4023 1650269
SGTC_2603 homopterocarpin 100 µM -0.898184471146912 0.18632123259046 no 2757 0.184543605419678 4000 101795 A weak amylase inhibitor.
SGTC_3127 9126946 49.47 µM -0.899369214824567 0.186013897907019 no 2758 0.184228015618368 3975 27243249
SGTC_320 4092-0846 5.34 µM -0.900026881755659 0.185843428085676 no 2759 0.184052972594614 3945 1359356
SGTC_137 0438-0332 85.389 µM -0.900741788197889 0.185658231505971 no 2760 0.183862812338186 3963 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1082 camptothecin 424.86 nM -0.900838440787376 0.185633202433405 no 2761 0.183837112799309 3886 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1666 st014829 29 µM -0.900902328022987 0.185616659398454 no 2762 0.183820126665927 3961 3858230
SGTC_274 sirtinol 40.1 µM -0.90231692440477 0.185250596572464 no 2763 0.183444268813827 4031 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_1397 3532-0190 20.1 µM -0.902866281357811 0.185108557413764 no 2764 0.183298434071086 3897 5322280
SGTC_958 1222-0007 33 µM -0.903039288817012 0.185063839426946 no 2765 0.183252521713429 4057 7312461
SGTC_3248 9135562 49.47 µM -0.903488531775424 0.184947752996985 no 2766 0.183133336050391 3970 17650701
SGTC_1089 terbinafine 2.25 µM -0.903513513112775 0.184941299033756 no 2767 0.183126709837333 3977 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3323 9138564 53.9225 µM -0.905652296296359 0.184389260412125 no 2768 0.182559959629038 4001 43912313 YNL103W MET4
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.906232348423515 0.184239720785211 no 2769 0.182406442263301 4054 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1036 k216-0215 33.5 µM -0.906666869265489 0.184127749132369 no 2770 0.182291494254359 3960 622330
SGTC_1246 0422-0085 105 µM -0.907792075961967 0.183837991603568 no 2771 0.181994042861159 4022 264295
SGTC_1351 1496-0003 46.5 µM -0.908263481576041 0.183716682082348 no 2772 0.181869515788734 4015 3891978
SGTC_7 0192-1582 4.227 µM -0.90889552747069 0.183554112352155 no 2773 0.181702637436792 4017 252616
SGTC_1395 3486-0190 4.35 µM -0.910315606324958 0.183189178302561 no 2774 0.181328045228824 3951 6748079
SGTC_387 norethindrone acetate 66.7 µM -0.910735729978417 0.183081301082164 no 2775 0.181217316641222 3983 541197
SGTC_490 phenamil 164 µM -0.910965706239775 0.183022265732999 no 2776 0.181156721601122 3959 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2565 isoliquiritigenin 100 µM -0.912702769551859 0.182576741983405 no 2777 0.180699443463694 4084 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2522 biochanin a 4.94 µM -0.913429546501084 0.182390538642409 no 2778 0.180508335947963 3996 5280373 A possible chelator.
SGTC_2445 5742597 35.57 µM -0.916416242837825 0.181626580633886 no 2779 0.179724309616313 3956 1774255
SGTC_2288 7946289 167.31 µM -0.917349870260038 0.181388182304498 no 2780 0.179479666215248 4051 1246052
SGTC_2712 st079126 47.7 µM -0.917351341480897 0.181387806788332 no 2781 0.179479280868624 3990 3152970
SGTC_1016 4226-1401 38 µM -0.918437495522253 0.181110708367187 no 2782 0.179194934042849 3958 2901613
SGTC_2035 5154463 94.595 µM -0.920519066918287 0.180580401734236 no 2783 0.178650786923431 4023 2769623
SGTC_1234 0326-0494 15.5 µM -0.921175686970547 0.180413321723092 no 2784 0.178479354858995 4084 1547813
SGTC_2219 9098279 200 µM -0.922083703372699 0.180182432596208 no 2785 0.178242458378017 3939 902349
SGTC_679 0422-0091 41.4 µM -0.924185361491952 0.17964873777097 no 2786 0.177694907902668 3972 627384 YHR062C RPP1
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.92453833435721 0.179559201404079 no 2787 0.177603051158201 3789 4000243
SGTC_872 0588-0139 234 µM -0.924674952926486 0.179524553776108 no 2788 0.17756750594061 3964 2047100
SGTC_2139 5578692 56.4705 µM -0.926825718489464 0.178979655293961 no 2789 0.177008514740546 3953 650991 YMR113W FOL3
SGTC_529 4076-0302 30.3 µM -0.927669111390729 0.178766265278171 no 2790 0.17678961791494 3955 5816522
SGTC_2298 7976326 193.81 µM -0.929459875527907 0.178313708636291 no 2791 0.176325405081809 3882 2235818
SGTC_1886 st057356 49.9 µM -0.929810726764933 0.178225127194161 no 2792 0.176234545716311 3968 24207747
SGTC_2061 5245884 80.95 µM -0.929878714718873 0.178207965090416 no 2793 0.176216942415932 3975 573863
SGTC_2320 7373003 200 µM -0.930151247575999 0.178139180460578 no 2794 0.176146389943892 4094 5415828
SGTC_535 2293-4129 48.2 µM -0.93196934514683 0.17768073872348 no 2795 0.175676184011226 4027 396118 YIL048W NEO1
SGTC_802 4112-3352 742 µM -0.932825157321212 0.177465199622995 no 2796 0.175455124913704 4075 704594
SGTC_2052 5265182 7.135 µM -0.934412880741449 0.177065763627335 no 2797 0.175045477970338 4023 1239884
SGTC_2143 5623677 140.463 µM -0.939011001272748 0.175912185984065 no 2798 0.173862548021432 3940 5375313
SGTC_2032 5185112 25.99 µM -0.939018018825504 0.17591042906404 no 2799 0.173860746553431 3897 5718189
SGTC_650 1328-0195 38 µM -0.939795072305472 0.17571595408729 no 2800 0.173661343471845 3989 2780821
SGTC_256 clotrimazole 625 nM -0.940889400766234 0.175442305050381 no 2801 0.173380769928731 3944 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1399 3562-5772 25 µM -0.941584124510228 0.175268721894216 no 2802 0.173202800387545 3960 23847490
SGTC_2840 9008771 71.43 µM -0.943861552756791 0.174700449395627 no 2803 0.172620200651888 3973 2992978
SGTC_199 4063-0024 41.6 µM -0.94522377564009 0.174361102129114 no 2804 0.172272321848268 4055 306215
SGTC_282 k297-0036 65.7 µM -0.948014336804687 0.173667246044315 no 2805 0.171561077810159 4035 5061378
SGTC_2463 5473429 200 µM -0.94802594504637 0.173664363399418 no 2806 0.171558123084791 4018 5399405
SGTC_2738 aclarubicin 5.55 µM -0.94895448028678 0.173433881234307 no 2807 0.171321881970162 3979 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2970 9090938 41.86 µM -0.953255320713008 0.172368862417049 no 2808 0.170230361578627 4117 17217104
SGTC_3106 9121286 49.47 µM -0.954040093906921 0.172174979752221 no 2809 0.170031673879531 4059 15943471
SGTC_1127 asiatic acid 681.4 nM -0.954474417651953 0.172067737459178 no 2810 0.169921776367432 3996 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1258 0671-0043 57.1 µM -0.955762429521667 0.171749955090166 no 2811 0.169596136854353 4067 4298767
SGTC_1360 1598-0022 39.8 µM -0.956951427746316 0.171456934648251 no 2812 0.169295885918509 4090 761525
SGTC_450 aminopyrene 156 nM -0.957256611574261 0.171381775749375 no 2813 0.16921887465243 3937 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2588 indole-3-carbinol 100 µM -0.96154363533756 0.17032821882275 no 2814 0.168139448199317 4104 3712 Induces cell cycle arrest.
SGTC_1031 k035-0009 16 µM -0.961721181383658 0.170284675674387 no 2815 0.168094839762288 4115 5180959
SGTC_2362 9071156 126 µM -0.963254235343454 0.169908991028896 no 2816 0.167709976833302 4087 653133
SGTC_3326 9140064 16.379 µM -0.964212305621641 0.169674479820013 no 2817 0.167469748060263 3976 1868434
SGTC_3125 9127534 49.47 µM -0.965998165775084 0.169237901198872 no 2818 0.167022549431071 3934 1639235
SGTC_2166 5933061 31.504 µM -0.968087323331971 0.168728093407134 no 2819 0.166500380164397 4151 2877375
SGTC_2580 diallyl disulphide 81.36 µM -0.968532195250779 0.168619660889122 no 2820 0.166389324007747 4044 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_780 0109-0199 192 µM -0.968626932375158 0.168596575568723 no 2821 0.166365680366131 4167 610414
SGTC_1325 1431-0015 227 µM -0.972944572685918 0.167546619728067 no 2822 0.165290425237828 4051 1103340
SGTC_865 0488-0499 301 µM -0.973098338283169 0.167509305133744 no 2823 0.165252214925424 4052 9634651
SGTC_2594 a-mangostin 100 µM -0.973226498313766 0.16747820838283 no 2824 0.165220371891512 4092 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2488 5268135 45.7 µM -0.973239537786661 0.167475044693489 no 2825 0.165217132286714 4112 1270356 YLR208W SEC13
SGTC_3265 9137266 49.47 µM -0.973548341829101 0.167400132668698 no 2826 0.165140423175282 3942 17224265
SGTC_1615 st002656 86.5 µM -0.975058375023722 0.16703412837368 no 2827 0.164765652293393 4056 1584458
SGTC_722 3534-0461 190 µM -0.975077885582704 0.16702940275208 no 2828 0.164760813630878 4114 658262
SGTC_335 4077-0256 27.6 µM -0.97561585489196 0.166899136020444 no 2829 0.164627432294016 4049 3121989
SGTC_1556 plumbagin 1.48 µM -0.976507306545401 0.166683419514171 no 2830 0.164406564442483 3976 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1009 4106-0057 9.87 µM -0.979043346595098 0.166070724378807 no 2831 0.163779281145259 4059 2928005
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.979623111976851 0.165930860448934 no 2832 0.163636096046995 3922 6708630 An antioxidant.
SGTC_2859 9028643 45.46 µM -0.980554174372704 0.165706408165642 no 2833 0.163406320974118 3947 17151580
SGTC_1668 st014914 51.6 µM -0.984196945213361 0.164830128741144 no 2834 0.162509343752076 4080 2839556
SGTC_1447 4239-0816 81.9 µM -0.985328842504499 0.164558459778569 no 2835 0.162231284838923 4083 1341554
SGTC_327 1273-0057 3.96 µM -0.985964578249868 0.164406002885013 no 2836 0.162075247593764 3948 3108138
SGTC_2176 5809774 33.9695 µM -0.986792646596393 0.164207559727307 no 2837 0.161872150171289 4031 2870539
SGTC_822 1487-0950 154 µM -0.987922948118046 0.163936938473395 no 2838 0.161595192837441 4092 1958375
SGTC_2617 dihydrotanshinone i 20.83 µM -0.988761912762535 0.163736257470801 no 2839 0.161389821518679 4066 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1249 0481-0015 10.2 µM -0.9903005144349 0.163368637310367 no 2840 0.161013627607617 4029 4227577
SGTC_1066 ketoconazole 628 nM -0.990498847970351 0.163321288254897 no 2841 0.160965175984509 4143 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2879 9041815 71.43 µM -0.992301593732495 0.162891319521043 no 2842 0.160525213055748 4092 4942971
SGTC_2213 7173844 200 µM -0.995054466724066 0.162236159576029 no 2843 0.159854887285505 4039 892728
SGTC_2095 5432005 200 µM -0.995145495448617 0.162214524870874 no 2844 0.159832753070718 4093 783734
SGTC_2821 7996764 71.43 µM -0.995829512270385 0.162052015376092 no 2845 0.159666494157408 4139 2987135
SGTC_2149 5554786 194.827 µM -0.99604704247166 0.162000356533627 no 2846 0.159613644425588 4104 745063 YPR165W RHO1
SGTC_623 k072-0108 16.9 µM -0.996117893648026 0.161983533187176 no 2847 0.159596433353637 4047 5382803
SGTC_2413 inermin 26.06 µM -0.997341335301972 0.161693211047874 no 2848 0.159299428138473 4193 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1885 st057546 99.9 µM -0.99862226074775 0.161389611676022 no 2849 0.158988856146684 4137 702008
SGTC_2489 cantharidin 73.42 µM -0.999872397653618 0.161093668367368 no 2850 0.158686131933588 4039 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3049 9092223 49.47 µM -1.00008244599229 0.161043978663078 no 2851 0.158635305237349 4070 8623917
SGTC_2753 fluvastatin 17.09 µM -1.001099537638 0.160803513716366 no 2852 0.158389344281772 4111 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2523 spermine 47.74 µM -1.0053655718247 0.159797475671445 no 2853 0.157360425704152 4104 1103 A DNA binding polyamine.
SGTC_1998 st075797 76.8 µM -1.00622712943189 0.159594799588936 no 2854 0.157153162347312 4084 24208315
SGTC_477 mead ethanolamide 10 µM -1.00715028807035 0.159377819039654 no 2855 0.156931279066503 4006 16061185
SGTC_1454 4239-0054 42.6 µM -1.00724414284305 0.159355770099202 no 2856 0.15690873240587 4211 1340767
SGTC_1162 k048-0130 20.1 µM -1.00796707733443 0.159186000828802 no 2857 0.156735133839185 4054 6797406
SGTC_2585 alliin 100 µM -1.01330369473101 0.157936450347017 no 2858 0.155457561641467 4171 87310 A garlic compound which reacts with lipids.
SGTC_3207 9114163 49.47 µM -1.01536396326214 0.157455773405172 no 2859 0.154966182249518 4158 849233
SGTC_672 1441-0018 53.7 µM -1.01667701188547 0.157149930947799 no 2860 0.154653552506902 4096 251141
SGTC_2669 eugenol 100 µM -1.02203596563948 0.155905747702995 no 2861 0.153381939156552 4093 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_694 1315-0438 43.2 µM -1.02609715662966 0.15496720172504 no 2862 0.152422895212744 4094 6793154
SGTC_90 0870-0863 4.608 µM -1.02857327455292 0.154396802820119 no 2863 0.151840120946744 4129 1738164
SGTC_1416 3966-0321 25.3 µM -1.02938066071096 0.154211113699622 no 2864 0.151650416610931 4156 582530 YLR208W SEC13
SGTC_2570 licareol 100 µM -1.02970408300078 0.154136771908048 no 2865 0.151574469165966 4121 443158
SGTC_1444 4112-3581 28 µM -1.03066401453663 0.153916261833085 no 2866 0.151349202733247 4155 2877249
SGTC_2226 7298446 200 µM -1.03267372826467 0.153455278070052 no 2867 0.150878306049636 4105 3283010
SGTC_2093 5331342 194.4 µM -1.03273379655823 0.153441513825225 no 2868 0.150864246454686 4194 33839
SGTC_1809 st050081 57.6 µM -1.03590542021123 0.152715919107725 no 2869 0.150123134352367 4222 5036894
SGTC_1660 st012960 28.1 µM -1.03669674446351 0.152535237617474 no 2870 0.149938604857793 4122 24207266
SGTC_3024 9090631 49.47 µM -1.0368641113412 0.152497041251645 no 2871 0.149899595837292 4106 25236383
SGTC_2313 7726885 200 µM -1.03719456506573 0.152421643944852 no 2872 0.149822595240226 4169 726423
SGTC_2167 5876490 200 µM -1.03760547990929 0.152327922904893 no 2873 0.149726882820883 4256 686534
SGTC_383 2324-0395 7.37 µM -1.03999236707021 0.151784280686829 no 2874 0.149171723444747 4129 3146421
SGTC_1275 0867-0008 21.1 µM -1.04171195183828 0.151393424554565 no 2875 0.148772623052494 4105 3422836
SGTC_2983 9022671 12.99 µM -1.04273803773394 0.151160517629375 no 2876 0.148534817878471 4147 6405161
SGTC_1383 3049-0032 20.7 µM -1.04340997510529 0.151008126622235 no 2877 0.148379227789245 4192 712864
SGTC_1415 3966-0071 78.1 µM -1.04420496082199 0.150827961136584 no 2878 0.148195286136598 4064 2893185
SGTC_1438 4092-1045 4 µM -1.04425898223803 0.150815723602108 no 2879 0.148182792345323 4137 1351342
SGTC_2358 9037157 4 µM -1.04555563807542 0.150522188986008 no 2880 0.147883120020807 4142 2388925
SGTC_1807 st050092 58.9 µM -1.04742465242387 0.150099754908903 no 2881 0.147451883309682 4163 5008496
SGTC_1972 st070201 17.4 µM -1.04926484679189 0.149684607594882 no 2882 0.147028120196587 4144 2829099
SGTC_916 4466-0038 42 nM -1.05013689686231 0.149488141140557 no 2883 0.146827588493911 4212 5722064 YGL116W CDC20
SGTC_756 0508-1999 28.3 µM -1.05187357919984 0.149097392297799 no 2884 0.146428777604035 4149 6753853
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.05229025130287 0.149003743764862 no 2885 0.146333201495493 4201 1273210
SGTC_410 α-linolenic acid 100 µM -1.05266426804851 0.148919715648955 no 2886 0.146247445341752 4209 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1679 SEC14.276 6.7 µM -1.0537364974485 0.148678999770289 no 2887 0.146001787111954 4137 1005053 YMR079W SEC14
SGTC_1583 clindamycin 39.6 µM -1.05375333562725 0.148675221668731 no 2888 0.145997931533129 4126 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_838 0109-0203 71.4 µM -1.05427988562251 0.148557108294985 no 2889 0.145877397488006 4152 759422
SGTC_2761 levamisole 97.89 µM -1.05775181832343 0.147779870655296 no 2890 0.145084302119729 4143 26879 An alkaline phosphatase inhibitor.
SGTC_1290 0986-0249 10.2 µM -1.05967737679182 0.147349985095415 no 2891 0.144645699195116 4020 53329
SGTC_1445 4239-0156 97.7 µM -1.06149023688111 0.146946026369398 no 2892 0.144233583750622 4232 4008346
SGTC_567 1080-0542 68.4 µM -1.06186933886425 0.146861645249614 no 2893 0.144147503093069 4016 5950415
SGTC_2747 doxorubicin 7.63 µM -1.06545624788098 0.146064874097136 no 2894 0.143334757301866 4140 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_652 0437-0092 114 µM -1.06686000785517 0.145753844679685 no 2895 0.14301752811087 4092 3091274
SGTC_2030 5175110 200 µM -1.06786537930276 0.145531359531548 no 2896 0.142790620651896 4164 2831986
SGTC_548 1436-0017 110 µM -1.06857143782201 0.145375247860597 no 2897 0.142631412208559 4226 9677137
SGTC_1281 0884-0031 11.8 µM -1.07037375284017 0.144977261505754 no 2898 0.14222555438544 4173 1548255
SGTC_3112 9123419 49.47 µM -1.07220456005993 0.144573735139962 no 2899 0.141814081341423 4208 17015854
SGTC_397 arbidol 50 µM -1.07371014163939 0.144242458941639 no 2900 0.141476307259011 4209 131410 A RNA synthesis inhibitor.
SGTC_575 k072-0246 11.9 µM -1.07517034549393 0.143921656477598 no 2901 0.141149234747725 4259 6796779
SGTC_1074 carmofur 3.8 µM -1.07960386686688 0.142950575677848 no 2902 0.140159309384334 4209 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1140 3229-1848 2.98 µM -1.08131809351246 0.142576295763389 no 2903 0.139777820831417 4193 2849525
SGTC_2693 st077581 40.7 µM -1.08139954016155 0.142558529413834 no 2904 0.139759713059841 4211 25238761
SGTC_1283 0922-0125 16.4 µM -1.08155703972712 0.142524177522605 no 2905 0.139724701211749 4170 3360884
SGTC_1846 st056244 14.8 µM -1.08170294980672 0.142492358385104 no 2906 0.139692271005408 4202 5393182
SGTC_1274 0865-0114 173 µM -1.08189904761008 0.142449602197894 no 2907 0.139648694057266 4171 870624
SGTC_2650 prasterone 100 µM -1.08444372249934 0.141895560910168 no 2908 0.139084053376958 4154 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1324 1418-0026 34.4 µM -1.08647890703464 0.1414535002728 no 2909 0.138633583981952 4214 1372513
SGTC_1652 st011932 78 µM -1.08817118493202 0.141086633467329 no 2910 0.138259771465294 4125 1551076
SGTC_1470 k295-0292 231 µM -1.08847613078332 0.141020593311442 no 2911 0.138192484166106 4266 5045612
SGTC_1690 st023502 41.2 µM -1.08889015800677 0.140930963667092 no 2912 0.138101163446428 4176 24207482
SGTC_1745 st081495 74 µM -1.09004175346125 0.140681866668565 no 2913 0.137847376009448 4065 13842402 YBL026W LSM2
SGTC_2987 9018338 71.43 µM -1.09533185087847 0.139541427233364 no 2914 0.136685639205437 4217 5055682
SGTC_1219 1469-0211 33.1 µM -1.0953336401259 0.139541042574041 no 2915 0.136685247411931 4223 6822282
SGTC_2218 6965428 192.983 µM -1.09606927277788 0.13938295452068 no 2916 0.136524230160585 4085 675684
SGTC_1160 4092-0570 10.5 µM -1.09934321320495 0.138680860203612 no 2917 0.135809195067747 4189 4994975
SGTC_2748 diazoxide 86.69 µM -1.10144730107002 0.138230913753294 no 2918 0.135351014216139 4248 3019 A potassium channel activatior.
SGTC_321 4534-3890 65.3 µM -1.10370578834068 0.137749058555967 no 2919 0.134860391951602 4200 699746
SGTC_3305 9127027 53.8275 µM -1.10417858804773 0.137648330549114 no 2920 0.134757837987623 4123 41905295
SGTC_1812 st052057 4.327 µM -1.10466152681785 0.137545494368681 no 2921 0.134653140040236 4210 3645418
SGTC_2981 9013952 38.96 µM -1.10831372279077 0.136769499915977 no 2922 0.133863175497673 4178 2996344
SGTC_2277 7947813 106.88 µM -1.10871210927364 0.136685034786191 no 2923 0.133777198170636 4256 1246798
SGTC_649 1123-0311 367 µM -1.11355310190814 0.135661506569089 no 2924 0.132735477692956 4097 693629 YIL048W NEO1
SGTC_3261 9137475 49.47 µM -1.11396369210009 0.135574937901977 no 2925 0.132647381598405 4135 17027690
SGTC_3069 9117009 49.47 µM -1.11533090534417 0.135286948105924 no 2926 0.132354323169801 4194 41904981
SGTC_3320 9137005 35.139 µM -1.11880505829872 0.134557040211768 no 2927 0.131611656640342 4240 4908713
SGTC_3351 9150312 21.596 µM -1.11941064488869 0.13443008568362 no 2928 0.131482495879391 4134 4904905
SGTC_2576 guaiol 23.12 µM -1.12082843346696 0.134133183727818 no 2929 0.1311804493143 4125 227829
SGTC_1331 1472-0049 76.2 µM -1.12146386873591 0.134000262249331 no 2930 0.131045231441243 4155 24051409
SGTC_2375 9072683 200 µM -1.12371019551023 0.133531097294414 no 2931 0.130567994874233 4295 16798029
SGTC_3004 9076122 71.4286 µM -1.12567733843662 0.133121171168265 no 2932 0.130151059616443 4243 44782551
SGTC_1403 3909-7815 62.9 µM -1.12702313420848 0.132841224886464 no 2933 0.129866349983634 4171 6615483
SGTC_1571 st070080 73.4 µM -1.12834401992159 0.13256685474005 no 2934 0.129587329793047 4245 4315245
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.12963579568326 0.132298909066405 no 2935 0.129314860617587 4116 17037758
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.13284029819242 0.131635829830654 no 2936 0.128640662533521 4259 6708561
SGTC_3269 9137823 49.47 µM -1.13326869350936 0.13154735989891 no 2937 0.128550717240456 4133 17682936
SGTC_3342 9147791 14.508 µM -1.14261161372189 0.129628112687593 no 2938 0.126599940732061 4180 1838168
SGTC_1400 3771-8998 51.5 µM -1.1430816904078 0.129532063451594 no 2939 0.126502337747014 4153 670767
SGTC_2396 5342950 42.78 µM -1.14325598996245 0.129496461925444 no 2940 0.126466160898657 4212 1886677
SGTC_699 0375-0592 111 µM -1.14609450091179 0.128917636407832 no 2941 0.125878026352192 4312 762578
SGTC_2024 5144227 134 µM -1.14673259288916 0.128787764923433 no 2942 0.125746077825137 4259 3475211
SGTC_1736 st036774 51 µM -1.14725864978558 0.128680764327983 no 2943 0.12563736917514 4293 1272247
SGTC_2860 9025725 38.96 µM -1.14749014108462 0.128633698273614 no 2944 0.125589552723659 4279 40546248
SGTC_1717 st033143 58.0435 µM -1.14777442805091 0.128575914321643 no 2945 0.125530848263263 4301 674616
SGTC_1133 3473-0247 50 µM -1.15085968034935 0.127949966794752 no 2946 0.124894983780097 4228 711311
SGTC_93 0109-0045 59.227 µM -1.15115482080581 0.127890198742935 no 2947 0.124834274049648 4363 88733
SGTC_2993 9054257 71.4286 µM -1.15249195442583 0.127619662683378 no 2948 0.124559486996561 4163 6470217 YGL055W OLE1
SGTC_165 k038-0023 64.381 µM -1.15564375177584 0.126983549047885 no 2949 0.123913452142629 4241 46368543
SGTC_1979 st071809 45.3 µM -1.15707461590091 0.126695493488911 no 2950 0.123620938286027 4315 4976333
SGTC_202 3594-0513 34.79 µM -1.16015453378364 0.126077002079238 no 2951 0.122992947214054 4303 708429
SGTC_2376 9072922 81.32 µM -1.16148341327 0.125810795236194 no 2952 0.122722682332097 4260 17087968
SGTC_668 1682-0499 62.6 µM -1.16300136595236 0.125507192431975 no 2953 0.122414474109854 4223 682214
SGTC_3013 9080133 71.4286 µM -1.16422825462162 0.125262178703855 no 2954 0.122165761393167 4341 17050193
SGTC_2405 ticlatone 3.52 µM -1.16574828126464 0.124959087786344 no 2955 0.121858116611555 4089 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.16823664082883 0.124464019353513 no 2956 0.121355662246061 4348 5282309
SGTC_1818 st052136 56.3 µM -1.16838981786498 0.124433589081383 no 2957 0.12132478010932 3944 674169
SGTC_3297 9117502 71.43 µM -1.16852839472591 0.124406063774173 no 2958 0.121296846286285 4275 7453720
SGTC_3285 9112818 20.8695 µM -1.1707459203655 0.123966179215876 no 2959 0.120850460630009 4234 17017947 YPR165W RHO1
SGTC_846 0335-0850 148 µM -1.17404736304139 0.123313299527062 no 2960 0.120188027563828 4232 6819598
SGTC_115 0527-0192 112.043 µM -1.17692476327506 0.122746244800753 no 2961 0.119612768592131 4251 4233931
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.18059967355617 0.122024686214529 no 2962 0.118880896690977 4294 5282362
SGTC_1043 0916-0009 19.3 µM -1.18070020819386 0.122004988462647 no 2963 0.118860919390612 4291 3101130
SGTC_1207 2099-0101 141 µM -1.18122089166003 0.121903006682967 no 2964 0.118757491995752 4263 5837381
SGTC_1194 1488-0194 225 µM -1.18124583409734 0.121898122926261 no 2965 0.118752539082198 4224 1391452
SGTC_2950 9072895 21.46 µM -1.18186057153683 0.121777800092515 no 2966 0.118630514473323 4241 17332245
SGTC_1884 5633444 25 µM -1.18287489683572 0.121579448231901 no 2967 0.118429365922336 4248 5724239
SGTC_2292 7671323 168.05 µM -1.18392918611526 0.12137352217929 no 2968 0.118220547842886 4319 937504
SGTC_2891 9063876 19.48 µM -1.18666842050151 0.120839635730071 no 2969 0.117679218042261 4293 6472478
SGTC_1873 rapamycin 2 nM -1.18712639737443 0.120750535934978 no 2970 0.117588883724695 4226 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1430 4049-0248 69.1 µM -1.18779944946209 0.120619677007064 no 2971 0.11745621568047 4284 22774488
SGTC_142 0335-0849 62.6745 µM -1.18993492729201 0.12020514534446 no 2972 0.117035984639282 4266 3889043 YPR107C YTH1
SGTC_1467 k284-1082 293 µM -1.19022034179579 0.120149817791788 no 2973 0.11697990002033 4247 3334705
SGTC_3189 9110682 49.47 µM -1.19171652636451 0.119860076269825 no 2974 0.11668620786558 4325 17122418
SGTC_2063 5246145 200 µM -1.19317534424969 0.119578045590139 no 2975 0.116400354329236 4316 711240
SGTC_2933 9026794 32.47 µM -1.1991161760177 0.118434350846357 no 2976 0.115241387536412 4231 17586027
SGTC_767 0929-0023 86 µM -1.20045275929688 0.118178108509447 no 2977 0.114981774562503 4304 1204563
SGTC_1390 3413-2614 145 µM -1.20095403211058 0.118082108426359 no 2978 0.114884516523689 4300 3421432
SGTC_2935 9038016 29.96 µM -1.20288886247085 0.117712081300649 no 2979 0.114509665421637 4270 6463195
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.20443308596781 0.117417345313593 no 2980 0.114211115215639 4265 442882
SGTC_813 k007-0158 173 µM -1.20816094053335 0.11670798826521 no 2981 0.113492681353112 4288 6523916
SGTC_2250 alverine citrate 130 µM -1.20928775781865 0.116494170415287 no 2982 0.113276156228204 4177 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2231 micatex 6.853 µM -1.21081193680831 0.116205393987774 no 2983 0.11298374463607 4306 20737 An antifungal of unknown mechanism.
SGTC_3162 9099653 49.47 µM -1.21460641550996 0.115488685994201 no 2984 0.112258120405517 4267 25237511
SGTC_467 ro 31-8220 72.8 µM -1.21489395934199 0.115434502504962 no 2985 0.1122032690024 4240 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_143 4032-1194 15.74 µM -1.21550446811691 0.115319520829914 no 2986 0.112086872838747 4330 1806963
SGTC_2667 digitoxin 100 µM -1.21759394399244 0.114926610390644 no 2987 0.111689158460529 4227 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_618 k072-0232 33.2 µM -1.21827162908999 0.11479938146284 no 2988 0.11156038379966 4351 5872756 YGL099W LSG1
SGTC_418 lividomycin a 100 µM -1.21958241897313 0.114553577554845 no 2989 0.111311607236893 4308 72394 An antibiotic.
SGTC_1596 piperlongumine 63 µM -1.22086507143929 0.11431341291796 no 2990 0.111068555590318 4338 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_791 1348-1292 225 µM -1.22171834662524 0.114153843862117 no 2991 0.110907077920221 4276 5437054
SGTC_730 1436-0052 41.2 µM -1.22203905745483 0.114093909497359 no 2992 0.110846428652443 4339 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3017 9080681 49.47 µM -1.2262537423373 0.11330835237291 no 2993 0.110051601447899 4327 16451914
SGTC_1581 himbacine 57.9 µM -1.22759947348627 0.113058341796312 no 2994 0.109798679786042 4311 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_3010 9080089 71.4286 µM -1.22799207834888 0.112985477710762 no 2995 0.109724970860093 4321 17027233
SGTC_2944 9067346 25.62 µM -1.22821589373206 0.112943954503574 no 2996 0.109682966925386 4254 6473075
SGTC_601 0986-0029 62.9 µM -1.22825346637371 0.112936984930927 no 2997 0.109675916715257 4245 24747981
SGTC_863 0466-0191 129 µM -1.22927684353779 0.112747270657977 no 2998 0.109484013152531 4351 765160 YPR165W RHO1
SGTC_695 3505-6186 243 µM -1.2297592927436 0.112657912901302 no 2999 0.1093936280215 4300 1819379
SGTC_1969 st069479 40.1 µM -1.23139303243173 0.112355692316403 no 3000 0.109087950825176 4308 3895485
SGTC_2584 androsterone 48.74 µM -1.23209787430845 0.11222548477496 no 3001 0.10895626268724 4238 2754130 A steroid.
SGTC_1253 0550-0034 176 µM -1.23537592483401 0.111621337822433 no 3002 0.108345314286806 4340 5969915
SGTC_86 0417-1630 471.922 µM -1.23594783418039 0.111516173384165 no 3003 0.108238977443022 4321 3634867
SGTC_2543 pimpinellin 60.67 µM -1.23697287974379 0.111327862332622 no 3004 0.108048575614584 4151 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1261 0712-0010 12.7 µM -1.23726285712549 0.111274631936266 no 3005 0.107994756209885 4319 2840123
SGTC_1802 st050112 57.9 µM -1.24002440655431 0.110768614312649 no 3006 0.107483183461095 4315 4662563
SGTC_1705 st027868 56.3335 µM -1.24148967654026 0.110500793362248 no 3007 0.107212454739497 4259 292948
SGTC_658 3253-0951 102 µM -1.24324524679676 0.110180523221132 no 3008 0.106888736956114 4315 1184878
SGTC_2084 5306078 60.6385 µM -1.24752612223243 0.109402352211099 no 3009 0.106102324078087 4268 679340
SGTC_2861 9024595 19.48 µM -1.2498665429255 0.108978586948027 no 3010 0.105674151512696 4230 16482810
SGTC_1317 1273-0028 910 nM -1.249906678993 0.108971330067445 no 3011 0.105666819657605 4341 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2682 pyrogallin 40.03 µM -1.2574971663498 0.107605155412917 no 3012 0.104286832236931 4340 822798 An ATP competetive kinase inhibitor.
SGTC_3352 9151559 45.5865 µM -1.25826346311303 0.107467922337026 no 3013 0.104148245061651 4336 17159339
SGTC_12 0849-0099 9.267 µM -1.26008896576474 0.107141508524292 no 3014 0.103818635162215 4261 6071388
SGTC_1038 k292-0204 154 µM -1.26093839338315 0.10698986835843 no 3015 0.103665522064534 4277 4454212
SGTC_964 1287-0107 19.4 µM -1.26148852076893 0.106891742028235 no 3016 0.103566446618207 4347 51516812 YPR165W RHO1
SGTC_2015 5119600 184 µM -1.26930351882922 0.105504786513632 no 3017 0.102166415912578 4368 2828786
SGTC_207 4185-0010 4.486 µM -1.26979078293323 0.105418743084848 no 3018 0.102079582388187 4423 3761753
SGTC_403 arphamenine a 50 µM -1.27059553125154 0.105276747932705 no 3019 0.101936288779107 4337 5487158 An arginine aminopeptidase inhibitor.
SGTC_2014 4013930 200 µM -1.27592454365404 0.104339952673097 no 3020 0.100991096997887 4318 64556
SGTC_1997 st073024 93.8 µM -1.27747892881901 0.104067846396647 no 3021 0.100716607439192 4371 686268
SGTC_816 0325-0417 81.3 µM -1.27920783351657 0.103765794046145 no 3022 0.100411939027667 4378 68101
SGTC_839 0122-0028 230 µM -1.28434129328854 0.102872689616043 no 3023 0.0995112822164485 4376 759448
SGTC_2221 6807166 181.081 µM -1.28809635252244 0.102222941329165 no 3024 0.0988562124394081 4322 674925
SGTC_3177 9107506 49.47 µM -1.29084162158193 0.101749812335182 no 3025 0.0983793009543329 4318 8897194
SGTC_1521 st012942 49.4 µM -1.2912697176637 0.101676176718868 no 3026 0.0983050836925751 4304 24207259
SGTC_2397 5161689 200 µM -1.2919156338788 0.101565147914435 no 3027 0.0981931814724088 4419 2259942
SGTC_2217 6934799 96.0675 µM -1.29252311664562 0.101460806163453 no 3028 0.0980880228575921 4337 675606
SGTC_2994 9053520 71.4286 µM -1.29805909774568 0.100513537374525 no 3029 0.0971335140320334 4401 4647384
SGTC_789 1309-1135 70.6 µM -1.29893047358553 0.100365024814106 no 3030 0.0969838952625801 4319 3092424
SGTC_880 0833-0487 87.2 µM -1.29956807619898 0.100256456792175 no 3031 0.0968745235414874 4361 76075
SGTC_1939 st074455 53.6 µM -1.30208972762961 0.099827921551188 no 3032 0.0964428571579194 4351 1644229
SGTC_2476 5806916 10.51 µM -1.30277234348132 0.0997121467011723 no 3033 0.0963262476938182 4263 2870194
SGTC_1973 st070275 50.2 µM -1.30345503022136 0.0995964579716437 no 3034 0.096209729790083 4314 17118334
SGTC_2348 9022543 33.42 µM -1.3062735561661 0.0991198663229981 no 3035 0.0957297732298969 4383 3162678 YDL140C RPO21
SGTC_1760 st045453 10.4495 µM -1.3094033021879 0.0985926064709574 no 3036 0.0951988867486715 4409 3323419 YIL048W NEO1
SGTC_511 blebbistatin 171 µM -1.31273138700758 0.0980341885981136 no 3037 0.0946367386725479 4432 3476986 A myosin inhibitor.
SGTC_1078 idebenone 36.1 µM -1.31550752260625 0.0975701577806336 no 3038 0.094169695408122 4409 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_858 0438-0351 2.77 µM -1.31619597323022 0.0974553329736411 no 3039 0.0940541374541381 4357 2799119
SGTC_528 3492-0019 172 µM -1.31919825532851 0.0969557490250875 no 3040 0.0935514207099043 4383 2869262
SGTC_398 bronopol 33.3 µM -1.31979720010897 0.0968563091247894 no 3041 0.0934513683389151 4299 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2910 7948405 25.97 µM -1.32086257090393 0.0966796158751971 no 3042 0.0932735959211272 4326 2971328
SGTC_1363 1636-0063 10.4 µM -1.32153308662924 0.0965685313556466 no 3043 0.0931618389307833 4384 6072185
SGTC_2473 5854593 8.94 µM -1.32672249704308 0.0957119698647658 no 3044 0.0923002481059419 4292 2872951
SGTC_1990 st072050 59.8 µM -1.32784985234294 0.0955266304946036 no 3045 0.0921138570461975 4369 17233948
SGTC_753 1322-0200 289 µM -1.33042891591351 0.0951036210777995 no 3046 0.0916884963172449 4441 5403907
SGTC_470 aa-861 153 µM -1.33129017193095 0.0949626684615055 no 3047 0.0915467754021578 4345 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.33673906662529 0.0940744711255534 no 3048 0.0906539125503154 4465 4213774
SGTC_492 tmb-8 126 µM -1.3373724974825 0.0939716177085906 no 3049 0.0905505385743272 4404 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_831 k061-1017 217 µM -1.33878813668909 0.0937420531235281 no 3050 0.0903198269596013 4420 1240153
SGTC_167 3672-0051 66.205 µM -1.3391128000936 0.0936894630788358 no 3051 0.0902669770364044 4296 3237971
SGTC_2862 9027634 71.43 µM -1.33951181105478 0.0936248598131821 no 3052 0.0902020560047117 4347 5012562
SGTC_1107 amlodipine 47 µM -1.34100476147657 0.0933834302357722 no 3053 0.0899594533367844 4012 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_539 4859-0462 2.54 µM -1.34313949175601 0.0930390158648511 no 3054 0.0896134050206676 4429 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2365 9042475 200 µM -1.34379592273786 0.0929332971991036 no 3055 0.0895071941675367 4436 6464479
SGTC_3266 9136860 49.47 µM -1.34386717430299 0.0929218274301458 no 3056 0.0894956712643382 4171 4871271 YPR165W RHO1
SGTC_2496 diffractaic acid 79.83 µM -1.34419737206248 0.0928686872850218 no 3057 0.0894422856219378 4387 94870 An apoptosis inducer which activates caspases.
SGTC_3086 9117350 49.47 µM -1.34995409057772 0.0919458414175904 no 3058 0.0885153547714794 4363 2679265
SGTC_2678 equilin 100 µM -1.35026243292795 0.0918966040976966 no 3059 0.0884659090267087 4397 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_3137 9097352 49.47 µM -1.35121654205631 0.091744371900343 no 3060 0.0883130385551436 4416 44120435
SGTC_1398 3558-0053 112 µM -1.3515720746796 0.0916876929521923 no 3061 0.0882561243366728 4363 4532369
SGTC_3319 9138450 16.7555 µM -1.35284862133337 0.0914843999080504 no 3062 0.0880519980418336 4332 2029690
SGTC_466 geldanamycin 89.2 µM -1.35516688547413 0.0911160654777772 no 3063 0.0876821962646698 4414 5288382 HSP90 inhibitor.
SGTC_2466 5983409 37.09 µM -1.35777930813896 0.0907023133635649 no 3064 0.0872668612875841 4391 2879657
SGTC_1060 3448-7350 82 µM -1.35963029417181 0.0904100017014214 no 3065 0.0869734732814303 4343 570178
SGTC_179 1273-0063 6.77 µM -1.36264570830989 0.0899352999874888 no 3066 0.0864970980144674 4381 3108139
SGTC_2212 7123476 200 µM -1.363415594978 0.089814397901833 no 3067 0.0863757844629107 4419 1085715
SGTC_1334 1486-0610 236 µM -1.36369541813939 0.0897704847538141 no 3068 0.0863317233545377 4471 3742339
SGTC_798 1287-0182 476 µM -1.36481244627779 0.0895953465538055 no 3069 0.0861560029527556 4444 1649755
SGTC_2593 nobiletin 86.24 µM -1.36859717800575 0.0890038294433098 no 3070 0.0855626133129341 4392 72344 An anti-infammatory.
SGTC_1520 flindersine 88 µM -1.37249251033088 0.0883980671711357 no 3071 0.0849550844331471 4448 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2025 5147754 141 µM -1.37580556815066 0.0878852763583618 no 3072 0.0844409185534345 4381 315777 YLR208W SEC13
SGTC_1472 k841-0093 193 µM -1.37998787930465 0.0872411157744525 no 3073 0.0837951883909032 4523 X1472
SGTC_430 0958-0115 16.4 µM -1.38346457548274 0.0867083228107882 no 3074 0.0832612310292556 4349 6833180
SGTC_305 1682-2595 20.8 µM -1.38691094067493 0.086182581677311 no 3075 0.0827344606471249 4443 226033
SGTC_3213 9129884 49.47 µM -1.39067815479336 0.0856106270157329 no 3076 0.0821615224143313 4411 17190742
SGTC_425 3825-7017 13.1 µM -1.3926936366142 0.0853057973015 no 3077 0.0818562268496052 4451 3397440
SGTC_3321 9137793 26.8275 µM -1.39400386020564 0.0851080702952478 no 3078 0.081658219480262 4393 4904192
SGTC_2646 retinol 96.75 µM -1.4010653203965 0.0840483291614458 no 3079 0.0805972704305189 4430 445354 A vitamin A analog and teratogen.
SGTC_1471 k673-0312 37 µM -1.40547116075068 0.0833921648606246 no 3080 0.0799406095864425 4412 24099884
SGTC_400 oxethazaine 37.5 µM -1.40569504218415 0.0833589251644885 no 3081 0.0799073498969451 4470 4621 A local anesthetic.
SGTC_2625 euphol 100 µM -1.40830587572972 0.0829720294566403 no 3082 0.0795202582748033 4439 6708538 A triterpene alcohol.
SGTC_2711 st079103 59.1 µM -1.40960704779812 0.0827797156719949 no 3083 0.0793278724020577 4374 54693780
SGTC_2856 9022925 19.48 µM -1.41025062084839 0.0826847193637805 no 3084 0.0792328467035393 4452 4944862
SGTC_1631 benzylvanillin 81.9 µM -1.41526569573466 0.0819472647063444 no 3085 0.0784953044818883 4488 75506
SGTC_2764 methyldopa 94.69 µM -1.41730265426666 0.0816491542593598 no 3086 0.0781972297398863 4412 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_183 3914-0051 30.55 µM -1.42109177543328 0.0810967896420261 no 3087 0.0776450403444081 4436 1596232
SGTC_1725 st036284 20.55 µM -1.42109716016243 0.0810960066869582 no 3088 0.0776442577386913 4473 707914
SGTC_1800 st050079 29.0735 µM -1.4243731639048 0.0806207230415083 no 3089 0.0771692391955487 4266 3645560
SGTC_3230 9131665 49.47 µM -1.42442798259491 0.0806127878641472 no 3090 0.0771613093451787 4459 15943720
SGTC_3018 9082602 49.47 µM -1.42592628708505 0.080396131922747 no 3091 0.0769448103214105 4373 17332089
SGTC_2716 st080858 38.6235 µM -1.42784409106148 0.0801194583842103 no 3092 0.0766683694359467 4428 5296050
SGTC_2248 tofa 1.1 µM -1.42833038079673 0.0800494179274562 no 3093 0.076598393633031 4477 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2886 9058944 51.95 µM -1.430237425614 0.0797751923700801 no 3094 0.0763244436643613 4400 4949929
SGTC_96 0929-0093 37.281 µM -1.4337935492868 0.0792657345289042 no 3095 0.0758155931864094 4458 6991579
SGTC_350 k064-0020 19.8 µM -1.43459147934228 0.0791517604500604 no 3096 0.0757017720366574 4474 2790705
SGTC_521 r062-0005 13.8 µM -1.44332881093114 0.0779118516933219 no 3097 0.0744639337321965 4387 2832033
SGTC_3095 9117207 49.47 µM -1.44623863490342 0.0775022090875416 no 3098 0.0740551404052942 4458 17015229
SGTC_2196 6573537 42.6665 µM -1.4465792376047 0.0774543664498501 no 3099 0.0740074023556782 4488 2903087
SGTC_1948 st076329 66.6 µM -1.44883003715868 0.0771387723682877 no 3100 0.0736925266017748 4386 24208413
SGTC_1171 0368-0077 21.4 µM -1.44918499838168 0.0770890910869394 no 3101 0.0736429629056963 4454 3239779
SGTC_889 0919-1524 82.7 µM -1.45207919029332 0.0766849195706699 no 3102 0.0732397937019346 4480 3905452
SGTC_312 4092-0653 6.84 µM -1.46159410684232 0.0753675233150301 no 3103 0.0719262351311218 4369 1148278
SGTC_794 k038-0031 316 µM -1.46213788610384 0.0752927582407487 no 3104 0.0718517142939229 4460 6624242
SGTC_3050 9093513 49.47 µM -1.4666455164015 0.0746751723102786 no 3105 0.0712362556392154 4427 25236664
SGTC_1096 rimcazole 32.2 µM -1.4747571074417 0.0735735594547048 no 3106 0.0701389283215096 4426 18528119 A dopamine reuptake inhibitor.
SGTC_1746 st038117 42 µM -1.47579050905848 0.0734341130304797 no 3107 0.0700000697012794 4503 2898218
SGTC_2192 5915882 198.485 µM -1.47594330529016 0.0734135119880116 no 3108 0.0699795563671759 4468 2876149
SGTC_2083 5306046 65.942 µM -1.47936683960175 0.0729530856410995 no 3109 0.069521148875178 4469 539837
SGTC_2643 anethole 100 µM -1.48089604335226 0.0727481406920898 no 3110 0.0693171387766491 4480 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_3139 9095020 49.47 µM -1.48163281713795 0.0726495552622923 no 3111 0.0692190110225099 4357 25236292
SGTC_2812 7970281 58.44 µM -1.48232918418938 0.0725564706162588 no 3112 0.0691263632841486 4505 2233435
SGTC_3117 9124945 49.47 µM -1.4832955004596 0.0724274527440129 no 3113 0.0689979586509549 4391 17592065
SGTC_2220 6782180 200 µM -1.48809049115232 0.0717898473665128 no 3114 0.0683635154085037 4432 833803
SGTC_716 1683-5115 658 µM -1.49037046759754 0.0714881858283469 no 3115 0.0680634266144421 4483 723597
SGTC_1917 st066507 28.5 µM -1.49289941532802 0.07115472204685 no 3116 0.067731759110701 4442 3156428
SGTC_3223 9129970 49.47 µM -1.49351329963451 0.0710739564877314 no 3117 0.0676514377692147 4506 17248386
SGTC_2094 5332512 191.667 µM -1.4936940211077 0.0710501933237578 no 3118 0.0676278059861682 4510 755774
SGTC_2841 9004761 38.96 µM -1.49465342542773 0.0709241428974433 no 3119 0.067502457650339 4435 2991039
SGTC_1882 5615643 20 µM -1.4947825483422 0.0709071913293721 no 3120 0.067485601167627 4464 2253075
SGTC_2339 9000433 200 µM -1.49664550030911 0.0706629647453812 no 3121 0.0672427620851314 4468 2988954
SGTC_1511 0906-3109 28.5 µM -1.49670003805923 0.070655824786075 no 3122 0.0672356631847039 4495 2882180
SGTC_600 1495-0418 41.6 µM -1.49684562062368 0.0706367681602748 no 3123 0.0672167162834592 4469 5377768
SGTC_1849 st056239 19.2 µM -1.49883013373293 0.0703773909576051 no 3124 0.0669588525202907 4486 5393181
SGTC_16 erodoxin 22.806 µM -1.49915854436896 0.0703345381773365 no 3125 0.0669162533735882 4521 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3114 9122766 49.47 µM -1.50310189054948 0.0698215548475942 no 3126 0.0664063856940075 4491 17176985
SGTC_1684 st024538 14.6195 µM -1.5050004202456 0.0695756074721698 no 3127 0.0661619843470012 4465 6732859
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -1.50509580320055 0.0695632685906186 no 3128 0.0661497239237706 4500 3256 An antibiotic and ribosome inhibitor.
SGTC_3119 9125183 49.47 µM -1.50611588958046 0.0694314140376463 no 3129 0.0660187131413654 4365 22695334
SGTC_2796 7949634 45.45 µM -1.50700321635589 0.0693168763663518 no 3130 0.0659049163888154 4460 2971588
SGTC_2843 9000894 45.46 µM -1.50740612183371 0.0692649167054225 no 3131 0.0658532952886823 4487 2242070
SGTC_835 0312-0010 67.2 µM -1.51222677225615 0.0686455589687137 no 3132 0.0652380912430959 4518 1626196
SGTC_131 0141-0277 33.849 µM -1.51391764900906 0.0684293296577841 no 3133 0.0650233636265374 4455 1547771
SGTC_462 ag-879 158 µM -1.51689483561384 0.068049884718542 no 3134 0.0646466188596787 4528 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2432 5630864 12.22 µM -1.52058925026343 0.0675812894202116 no 3135 0.0641814730538835 4512 5714970
SGTC_2524 avocatin b 10.57 µM -1.52411207407717 0.0671367844762947 no 3136 0.0637403585244823 4522 6710748
SGTC_728 3030-5151 22.5 µM -1.52421342840137 0.0671240292692497 no 3137 0.0637277023150455 4578 3125388
SGTC_216 k038-0035 28.382 µM -1.52928834150603 0.0664877561244584 no 3138 0.0630964892650297 4440 4444231 YPR107C YTH1
SGTC_1754 st042065 16.137 µM -1.53046129416517 0.0663413622458889 no 3139 0.0629512935554559 4256 1126236 YIL048W NEO1
SGTC_608 k048-0125 159 µM -1.53369755126873 0.0659387457524879 no 3140 0.0625520382394304 4557 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_3332 9141069 11.198 µM -1.54172623511877 0.0649480885522654 no 3141 0.0615700669334928 4459 17332883
SGTC_68 0986-0284 82.829 µM -1.54528191081406 0.0645130630942132 no 3142 0.0611390444836422 4488 423278 YIL048W NEO1
SGTC_2847 9005661 71.43 µM -1.5520240848966 0.0636943991653296 no 3143 0.0603282304057001 4557 2991449
SGTC_454 lyso-paf C-16 6.67 µM -1.55448480103676 0.0633976297109189 no 3144 0.0600344096692687 4536 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_619 1652-1634 108 µM -1.55717305249869 0.0630746502301769 no 3145 0.0597147022326731 4522 5400454
SGTC_2109 5483026 200 µM -1.56150641050114 0.062556719356846 no 3146 0.0592021562504649 4543 759335
SGTC_51 1013-0126 23.419 µM -1.56332262369805 0.0623406307122906 no 3147 0.0589883647902988 4511 1627850
SGTC_3034 9090421 49.47 µM -1.57139011996555 0.0613878079035504 no 3148 0.0580460297504378 4452 17173761
SGTC_1935 st074532 41.6 µM -1.57450507179612 0.0610229710795383 no 3149 0.0576853649629287 4494 2829742
SGTC_744 1594-0068 283 µM -1.57576638495363 0.0608757235388729 no 3150 0.0575398259865963 4517 668392
SGTC_2156 5649887 115 µM -1.57997189094253 0.0603867733202867 no 3151 0.0570566519312388 4566 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_940 3232-1287 54.8 µM -1.58082329717512 0.0602881602714914 no 3152 0.0569592230578436 4522 1585493 YIL048W NEO1
SGTC_2896 9052656 71.43 µM -1.58188726265975 0.0601651050438074 no 3153 0.056837654604391 4229 6469436
SGTC_2310 7668677 200 µM -1.58504106558368 0.0598015002546626 no 3154 0.0564785021389857 4507 2197143
SGTC_1796 st049173 110.4 µM -1.58596835082042 0.0596949208241389 no 3155 0.0563732445948592 4526 94134
SGTC_1339 1486-1321 22.7 µM -1.59175993824173 0.0590326169866277 no 3156 0.0557193274448082 4597 3469382
SGTC_1720 st037298 9.481 µM -1.59421146174013 0.0587540124247434 no 3157 0.0554443400999236 4525 597396
SGTC_1567 st069303 68.4 µM -1.59812010556302 0.0583119483215451 no 3158 0.055008124946831 4546 5581319
SGTC_2918 7977171 22.06 µM -1.60321100606921 0.0577400944093778 no 3159 0.0544440381957966 4533 2236483
SGTC_1597 7-benzyloxygramine 47.5 µM -1.60326106119852 0.0577344937554536 no 3160 0.0544385147408456 4442 260807
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -1.60521823414292 0.057515840929663 no 3161 0.0542228930092054 4535 229346 A bile salt which induces apoptosis.
SGTC_2199 6590217 200 µM -1.60595252457734 0.0574339751860008 no 3162 0.0541421707846476 4518 703109
SGTC_2495 cafestol 54.53 µM -1.6081220081181 0.0571926358077032 no 3163 0.0539042300073084 4537 16667697 An anti-infammatory.
SGTC_2069 5228469 200 µM -1.60967876985534 0.0570199497021588 no 3164 0.0537340010174764 4546 2835210
SGTC_2329 6138490 200 µM -1.61555344215094 0.0563719878632603 no 3165 0.0530954484679275 4564 720019
SGTC_763 3453-1109 128 µM -1.62510889632714 0.0553304584686002 no 3166 0.0520696788155746 4576 1560353
SGTC_2160 5660466 132.927 µM -1.62706419849165 0.0551192183728223 no 3167 0.0518617318613929 4499 2859134
SGTC_1900 st060200 72.8 µM -1.62756426005195 0.055065296905755 no 3168 0.0518086562835386 4536 688945
SGTC_884 0851-0618 334 µM -1.63148551374657 0.0546439129560199 no 3169 0.0513939570369307 4577 9642473
SGTC_3283 9109332 35.8195 µM -1.63214515141158 0.0545732784675651 no 3170 0.0513244560085725 4388 17027281
SGTC_33 0986-0033 35.816 µM -1.63596334966259 0.0541658404730335 no 3171 0.0509236290687056 4557 2848082
SGTC_595 3909-8003 73.7 µM -1.63676829703063 0.0540802529650843 no 3172 0.0508394461653876 4609 699517
SGTC_2800 7887935 81.82 µM -1.64021325796261 0.0537151698707816 no 3173 0.0504804168194335 4538 2961002
SGTC_2561 acetosyringone 100 µM -1.64136748714374 0.0535932868130965 no 3174 0.0503605773536621 4519 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1955 wogonin 32.4 µM -1.64195473065476 0.0535313598459579 no 3175 0.0502996930460636 4539 5281703 A flavanone.
SGTC_158 k038-0087 26.446 µM -1.64492082075354 0.0532194407220574 no 3176 0.0499930703071555 4473 X158
SGTC_2745 rifampicin 24.3 µM -1.6454449569502 0.0531644717558968 no 3177 0.0499390424554842 4676 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1027 k015-0025 8.67 µM -1.65551727943577 0.0521168524001414 no 3178 0.0489098071463238 4549 3598955
SGTC_2008 4012253 172 µM -1.65635818418225 0.0520301370498092 no 3179 0.0488246519846679 4572 603940
SGTC_1931 st074438 57.1 µM -1.66366297272401 0.0512816706122163 no 3180 0.0480898998676597 4581 2787313
SGTC_955 1216-0110 33 µM -1.66709507779595 0.0509329789443948 no 3181 0.0477477503718334 4546 3619719
SGTC_2502 avocadyne acetate 18.59 µM -1.66831493846977 0.050809500324324 no 3182 0.0476266119941267 4525 3952079
SGTC_1359 1582-0056 520 nM -1.67121598785803 0.0505168032321138 no 3183 0.0473395117172868 4615 3661189
SGTC_1251 0490-5699 265 µM -1.67610211114958 0.0500268630823069 no 3184 0.0468590966582291 4586 3883818
SGTC_304 1310-0298 97 µM -1.67708549400003 0.049928717079383 no 3185 0.0467628824861111 4323 1550234
SGTC_977 1348-1378 135 µM -1.68139097002838 0.0495008180250887 no 3186 0.046343499169325 4565 X977
SGTC_1913 st060213 96.1 µM -1.68217499396884 0.0494232138809787 no 3187 0.0462674557814454 4556 688959
SGTC_1465 k213-0056 144 µM -1.68239198825489 0.0494017525524049 no 3188 0.0462464269668721 4506 24048857 YMR208W ERG12
SGTC_3338 9144300 39.5675 µM -1.68622999363606 0.0490233914017042 no 3189 0.0458757544697185 4572 4901274
SGTC_2827 7993847 71.43 µM -1.70424223372885 0.0472785200941943 no 3190 0.0441679210031704 4613 2985692
SGTC_1634 st006576 41 µM -1.71219804977337 0.0465238452359439 no 3191 0.0434300883682732 4569 3915356
SGTC_1446 4239-0190 62 µM -1.71549798567913 0.046213669479385 no 3192 0.0431269821932839 4608 1340085
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.71717562631681 0.0460566184605803 no 3193 0.0429735437628097 4626 77254
SGTC_3183 9108214 49.47 µM -1.71892917110354 0.0458929202938637 no 3194 0.0428136348584914 4611 4974831
SGTC_784 4579-0127 173 µM -1.72212028174099 0.0455962212253638 no 3195 0.0425238658947277 4604 1948547
SGTC_1519 esterone 74 µM -1.7239770415412 0.0454242967035878 no 3196 0.0423559939241255 4599 698 A steroid.
SGTC_468 gf-109203x 121 µM -1.7270895647788 0.0451372660655566 no 3197 0.0420757897077577 4671 2396 A protein kinase C inhibitor.
SGTC_561 1550-0330 72.9 µM -1.72763675606272 0.0450869563518419 no 3198 0.042026684348179 4569 6812934
SGTC_886 0866-0150 153 µM -1.73450530399718 0.0444592807022469 no 3199 0.0414142327379178 4623 271463
SGTC_967 1306-0166 352 µM -1.74089185866067 0.0438819864855781 no 3200 0.0408512680274248 4598 4437607
SGTC_2096 5468907 200 µM -1.74139491721099 0.0438367720367471 no 3201 0.0408071892730976 4612 759785
SGTC_1158 4092-0494 91.8 µM -1.74786578069684 0.0432585207668095 no 3202 0.0402436357322859 4656 1148199
SGTC_1220 1838-0075 193 µM -1.75072738013366 0.0430047735816283 no 3203 0.0399964403864974 4540 5529645
SGTC_1843 st055809 45.5 µM -1.75595016079636 0.0425447540710093 no 3204 0.0395484594696072 4626 16413835
SGTC_1610 st001799 48.1 µM -1.76661832852959 0.0416174738260903 no 3205 0.03864608467569 4584 621897
SGTC_2953 9074162 66.49 µM -1.76958024945478 0.0413629471085681 no 3206 0.0383985457131118 4593 16451992
SGTC_85 0868-0259 160.055 µM -1.77199770859466 0.0411561439847773 no 3207 0.0381974687957888 4569 83173
SGTC_2713 st079149 53.4 µM -1.7739534556801 0.0409894524702358 no 3208 0.038035424757224 4637 3103253
SGTC_310 1273-0058 1.06 µM -1.77431357395535 0.0409588187811705 no 3209 0.0380056482678763 4294 2734232
SGTC_1176 0848-0131 83.3 µM -1.77805702009139 0.0406414787510699 no 3210 0.0376972452234856 4657 6769040
SGTC_3042 9091578 49.47 µM -1.77919867416231 0.0405450963269467 no 3211 0.0376035978385965 4613 25236497
SGTC_1451 4152-0210 104 µM -1.78505510723383 0.0400535891438345 no 3212 0.0371261893686728 4639 659563
SGTC_512 prima-1 270 µM -1.78738220841928 0.0398596337432498 no 3213 0.0369378675953758 4624 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_279 1273-0055 2.93 µM -1.78856623123111 0.0397612431870584 no 3214 0.036842350162718 4660 2847562
SGTC_2920 7982904 15.77 µM -1.79913699502714 0.0388915515507435 no 3215 0.0359985064313705 4591 6456808
SGTC_565 1418-0001 44.5 µM -1.80616318635945 0.038322101116873 no 3216 0.0354464266961035 4656 2862145
SGTC_1179 1021-1431 9.29 µM -1.80906258139255 0.0380891043351151 no 3217 0.0352206407347221 4632 2840958
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.81016578849639 0.0380007541092262 no 3218 0.0351350406221084 4683 16725076
SGTC_3039 9090270 49.47 µM -1.82047640267699 0.0371830871455565 no 3219 0.0343432433094041 4630 17173750
SGTC_927 2425-1185 123 µM -1.82173841931861 0.0370839999013768 no 3220 0.0342473427563328 4593 730375
SGTC_547 1120-0019 610 nM -1.82592698422816 0.0367566804113279 no 3221 0.0339306304673862 4604 3676939
SGTC_3180 9109287 49.47 µM -1.83416558538765 0.0361197611292526 no 3222 0.0333147091313119 4655 18891271
SGTC_3093 9117344 49.47 µM -1.83813560602474 0.0358160846944546 no 3223 0.0330212128141991 4656 24824913
SGTC_717 1532-0246 73.2 µM -1.8449611081857 0.0352988775526221 no 3224 0.0325215981513972 4636 9561992
SGTC_2505 galangin 7.89 µM -1.84534181222541 0.0352702107586078 no 3225 0.0324939158906893 4589 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_54 0159-0055 9 µM -1.85585522235942 0.0344860726391193 no 3226 0.0317370984411362 4616 3319099
SGTC_9 0092-0002 10.449 µM -1.85830408701572 0.034305496765968 no 3227 0.0315629218898629 4646 759368
SGTC_1845 st056753 3.01 µM -1.85950592949536 0.0342171592639609 no 3228 0.0314777297855058 4619 5375839
SGTC_969 1313-0238 134 µM -1.86147886697463 0.0340725504281206 no 3229 0.0313382911380369 4665 5212874
SGTC_2647 atorvastatin 60.16 µM -1.86969703311227 0.0334755864219644 no 3230 0.0307629508835235 4644 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1001 4048-4355 44.4 µM -1.87361202645799 0.0331942458626129 no 3231 0.0304919596058513 4642 21824233
SGTC_3260 9137109 49.47 µM -1.88466148660245 0.0324106962090657 no 3232 0.0297377776059204 4657 17478346
SGTC_2751 anetholtrithion 17.25 µM -1.89850414943359 0.0314506707906417 no 3233 0.0288148508441608 4608 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2955 9076254 12.21 µM -1.90734897346932 0.0308496583688251 no 3234 0.0282377061679883 4617 16459619
SGTC_1200 1643-0193 18.4 µM -1.90785009316368 0.0308158934530279 no 3235 0.0282052970926012 4673 5403974
SGTC_2810 7959871 45.46 µM -1.9095093201111 0.0307043147663232 no 3236 0.0280982102908119 4597 2974535
SGTC_992 3909-8734 162 µM -1.9176756176533 0.0301600168150288 no 3237 0.0275760776260715 4669 4288319
SGTC_1061 3448-9325 110 µM -1.92053075771071 0.0299716139839455 no 3238 0.0273954459474279 4638 723482
SGTC_2666 tannic acid 100 µM -1.92651552159632 0.0295798620796685 no 3239 0.0270200178274894 4647 16134267 A thiamine antagonist.
SGTC_1493 4348-0038 111 µM -1.93213367551612 0.0292159844841666 no 3240 0.0266715044035606 4676 800424
SGTC_3157 9099274 49.47 µM -1.93506040437752 0.0290279033958101 no 3241 0.0264914418452598 4666 17217662
SGTC_2429 5902844 64.44 µM -1.9381098059004 0.0288330103498642 no 3242 0.0263049136840656 4656 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2384 9036245 200 µM -1.9416744282882 0.0286065688137628 no 3243 0.0260882631481324 4657 6462766
SGTC_2605 digitonin 300 nM -1.95721239411257 0.0276367309716958 no 3244 0.0251612511156731 4647 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2541 muurolladie-3-one 83.07 µM -1.97499326480047 0.0265606786977571 no 3245 0.0241344561719717 4615 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2 0422-0095 29 µM -1.97555390686175 0.0265273275145124 no 3246 0.0241026617361503 4615 6790840
SGTC_2341 7987486 176.74 µM -1.97663719784096 0.0264629843821371 no 3247 0.0240413271630332 4685 1258686
SGTC_2045 5106652 78.05 µM -1.97672959905581 0.0264575021627204 no 3248 0.0240361015978278 4674 673349
SGTC_1116 jasmonic acid 1.58368 µM -1.98008919809991 0.0262588187651409 no 3249 0.0238467533545242 4712 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_3011 9081274 71.4286 µM -1.98238720428381 0.02612363656706 no 3250 0.0237179603042225 4683 6625322
SGTC_1340 1486-1359 257 µM -1.98447128193807 0.0260015426078157 no 3251 0.0236016632324646 4654 4309068
SGTC_803 4488-1585 147 µM -1.98530641555561 0.025952751139506 no 3252 0.0235551953481376 4681 747204
SGTC_1284 0929-0043 16 µM -1.98881599884354 0.0257485453438699 no 3253 0.0233607581062039 4675 1239883
SGTC_943 3253-1379 105 µM -1.99004518591521 0.0256773435788372 no 3254 0.023292979071493 4647 668464
SGTC_2659 sanguinarine 24.21 µM -1.99605165622248 0.0253317797039657 no 3255 0.0229641501953581 4660 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_946 3434-1334 87.4 µM -1.99835679082144 0.0252001994043717 no 3256 0.0228389963026962 4660 4047976
SGTC_1832 st054113 55 µM -1.99959469658286 0.0251297747075513 no 3257 0.0227720235423416 4707 1251267
SGTC_3176 9106582 49.47 µM -2.00624079668863 0.0247544910717085 no 3258 0.0224152815638784 4714 17018027
SGTC_633 0437-0093 97.7 µM -2.01191499658148 0.0244378184392899 no 3259 0.0221144491373669 4642 2831118
SGTC_2552 juarezic acid 87.02 µM -2.01673524296513 0.0241714823441368 no 3260 0.0218615749946309 4664 1549512
SGTC_4 0960-0234 25.671 µM -2.02485454136867 0.0237283749085164 no 3261 0.0214411513146821 4642 6821112
SGTC_2766 oltipraz 83.91 µM -2.03724669215607 0.0230652572474519 no 3262 0.0208126634563742 4674 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2717 st081029 62.2815 µM -2.03766948266749 0.0230429113767158 no 3263 0.02079149905536 4682 5292846
SGTC_1169 aniline yellow 25.8 µM -2.03801089931499 0.0230248796911725 no 3264 0.0207744214371136 4663 6051 A DNA damaging agent.
SGTC_113 0099-0221 2.5 µM -2.0459961099731 0.0226065234843489 no 3265 0.020378376701415 4655 89219
SGTC_1861 st057647 17.4 µM -2.04825660975515 0.0224892631555267 no 3266 0.0202674310793657 4700 688668
SGTC_2021 4019055 173 µM -2.0591934403957 0.0219291492369783 no 3267 0.0197378556574626 4487 44827708 YER133W GLC7
SGTC_1749 st037932 54.2 µM -2.06237129912222 0.0217686254007167 no 3268 0.0195861998182731 4667 594497
SGTC_2946 9065502 71.43 µM -2.06399678730029 0.0216869012065386 no 3269 0.0195090104991464 4616 16489101
SGTC_584 0986-0246 15.4 µM -2.07415652032389 0.0211819553351492 no 3270 0.0190323884047412 4738 53315 YDR232W HEM1
SGTC_2518 prenyletin 46.28 µM -2.07456819291093 0.0211617063432265 no 3271 0.0190132862672638 4733 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1048 3161-0300 24.5 µM -2.07757237179714 0.0210144346050855 no 3272 0.0188743815288061 4700 2165101
SGTC_2520 obtusaquinone 4.71 µM -2.08013570512357 0.0208894607591519 no 3273 0.0187565437302068 4706 5967872
SGTC_3246 9135460 32.98 µM -2.08145398410335 0.0208254341750696 no 3274 0.0186961859126031 4715 41446951
SGTC_769 0302-0231 76 µM -2.10011885933141 0.0199365962845484 no 3275 0.0178591933544122 4646 571869 YER009W NTF2
SGTC_1564 D-Arginine 115 µM -2.13174821766019 0.0185038642167534 no 3276 0.0165137753112077 4691 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1332 1480-0653 17.5 µM -2.1354799761175 0.0183407543999448 no 3277 0.0163609120493225 4719 5749438
SGTC_2884 9058502 51.95 µM -2.15749948413041 0.0174030458562631 no 3278 0.0154833836410446 4708 6471554
SGTC_3253 9135987 49.47 µM -2.16304262186844 0.0171735450708035 no 3279 0.0152689507883894 4717 4182430
SGTC_2351 9026858 72.31 µM -2.1782823667812 0.0165558646341894 no 3280 0.0146925105657754 4652 1409300
SGTC_2205 7238770 200 µM -2.17879146638059 0.0165355629035882 no 3281 0.0146735815942599 4735 279867
SGTC_1459 k035-0031 35.7 µM -2.19079123210915 0.0160631731283463 no 3282 0.0142334517026307 4565 3877128 YMR208W ERG12
SGTC_1076 itraconazole 331 nM -2.19277126642745 0.0159863482264091 no 3283 0.0141619315673853 4733 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1488 4013-0813 75.9 µM -2.20215336796413 0.0156265924657327 no 3284 0.0138272383801569 4749 2910057
SGTC_439 amiodarone 34.4 µM -2.20911552320183 0.0153641397778148 no 3285 0.0135833033342477 4618 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1768 st044301 37.178 µM -2.20955425016903 0.0153477285959843 no 3286 0.0135680567048708 4731 3931349
SGTC_1762 st045503 25.4615 µM -2.21325535158616 0.0152098819789954 no 3287 0.0134400229645833 4727 4645554
SGTC_1744 st037937 38.9 µM -2.2145433173188 0.0151621621137674 no 3288 0.0133957131630513 4720 1016152
SGTC_1315 1237-0019 3.69 µM -2.21820844851598 0.0150270701404836 no 3289 0.0132703114811507 4721 825140
SGTC_1370 2001-0092 44.6 µM -2.22010124725988 0.0149577100240828 no 3290 0.0132059477841619 4680 790957
SGTC_3224 9130643 49.47 µM -2.23624571445263 0.0143772129382517 no 3291 0.0126678401118426 4712 17644395
SGTC_84 0443-0269 128.823 µM -2.24672593580466 0.0140108547969129 no 3292 0.0123287738298485 4717 6150058
SGTC_1260 0700-1617 7.75 µM -2.27348925542783 0.013111596067704 no 3293 0.0114983564428872 4711 2853078
SGTC_2791 5663188 71.43 µM -2.27707115312841 0.0129951116225487 no 3294 0.0113909884930799 4714 54690634
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -2.27913326651072 0.0129284576908875 no 3295 0.0113295722700132 4753 4174840
SGTC_405 ebelactone b 50 µM -2.29722202858715 0.0123563358245626 no 3296 0.0108030535510941 4722 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3218 9131285 49.47 µM -2.31730991434096 0.011746809257865 no 3297 0.0102434278111825 4704 17156417
SGTC_3251 9135047 49.47 µM -2.3260025827018 0.0114912446939071 no 3298 0.0100092064508145 4768 17682963
SGTC_1186 1319-0216 26 µM -2.37548790208558 0.0101264446764791 no 3299 0.00876288345351115 4770 4565136
SGTC_2078 5212016 200 µM -2.39690118986009 0.00958114684924895 no 3300 0.00826719090690232 4711 1899708
SGTC_731 3966-0296 387 µM -2.41340388030112 0.00917858571095633 no 3301 0.0079021479249862 4758 660956
SGTC_2151 5563267 85.4165 µM -2.41727263853499 0.0090863831288157 no 3302 0.00781864982370974 4774 5310824
SGTC_3155 9099265 49.47 µM -2.41738556459439 0.00908370403297813 no 3303 0.00781622428235225 4735 25236499
SGTC_1297 1068-0111 14.1 µM -2.43114155894458 0.00876248253279967 no 3304 0.0075256663522754 4766 767057
SGTC_1418 3966-3099 2.4 µM -2.43166691770497 0.00875041462361656 no 3305 0.00751476071735811 4770 740335
SGTC_3149 9097855 49.47 µM -2.43719634702759 0.0086242803502362 no 3306 0.00740081992490636 4731 25236625 YMR079W SEC14
SGTC_2215 7188065 200 µM -2.43865954085905 0.00859117078513802 no 3307 0.00737092488853007 4770 940217
SGTC_3040 9091894 49.47 µM -2.4931941645718 0.00743408223541981 no 3308 0.00632997977732673 4727 25236966
SGTC_945 3381-0768 11.3 µM -2.49379394885435 0.0074221596383797 no 3309 0.0063192944096252 4747 1126236 YIL048W NEO1
SGTC_2147 5545932 89.7195 µM -2.49636395296383 0.00737126329742557 no 3310 0.00627368946268673 4778 797404
SGTC_2354 9060492 162 µM -2.49865189193026 0.00732621204769404 no 3311 0.00623333522653201 4754 6471895
SGTC_3334 9142812 21.919 µM -2.50644673704186 0.00717454249578416 no 3312 0.00609757148702653 4738 45283678
SGTC_1338 1486-1223 76 µM -2.51639892097202 0.00698492573599109 no 3313 0.0059280451403033 4759 3444526
SGTC_2825 7998094 58.44 µM -2.53863247073237 0.00657721612339999 no 3314 0.00556433314722496 4734 2987815
SGTC_3111 9122088 49.47 µM -2.57853041258014 0.0058980887636873 no 3315 0.00496107826279972 4761 16876704
SGTC_3045 9092950 49.47 µM -2.58224864344776 0.0058380835244375 no 3316 0.00490794182365672 4752 44120432
SGTC_2612 dictamnine 15.46 µM -2.58380180062686 0.00581317927745834 no 3317 0.00488589656799358 4719 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2002 4023503 131 µM -2.59793272276802 0.0055908905355071 no 3318 0.00468934336531306 4753 4736863 YCR052W RSC6
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -2.60071931003892 0.00554795767256942 no 3319 0.00465142678903819 4778 688662
SGTC_2550 chrysin dimethyl ether 71.87 µM -2.60161080394594 0.00553428442368866 no 3320 0.00463935428547848 4738 88881 An O-methylated flavonoid and antioxidant.
SGTC_3186 9110464 49.47 µM -2.61008118234361 0.00540585648209753 no 3321 0.00452603690384927 4778 17018021
SGTC_924 2046-0044 21.3 µM -2.61655396869777 0.00530950891307921 no 3322 0.00444111609001993 4757 3623589
SGTC_40 0327-0103 19.753 µM -2.68483025704175 0.00438249887246956 no 3323 0.00362833251319716 4678 409036
SGTC_3219 9131112 49.47 µM -2.70942486784911 0.0040858094464299 no 3324 0.00336999842060173 4689 17612988 YMR079W SEC14
SGTC_2691 st077356 60.2 µM -2.75367426656762 0.00359696935477301 no 3325 0.00294651937206985 4756 2839272
SGTC_1712 st032288 53.4 µM -2.78452895713318 0.00328786988823352 no 3326 0.00268027671686446 4671 2883011
SGTC_538 2922-0838 53.3 µM -2.83243858630484 0.00285506899592696 no 3327 0.00230972194685092 4792 777039
SGTC_1054 3429-0080 167 µM -2.83363854328848 0.00284492144416702 no 3328 0.00230106770903679 4776 1162877
SGTC_2536 dehydroabietamide 32.04 µM -2.84941121250362 0.00271452947568634 no 3329 0.00219001145085838 4779 3983547
SGTC_2004 4023728 41.89 µM -2.93161566825946 0.0021182995367718 no 3330 0.00168601883928723 4773 360084 YDR527W RBA50
SGTC_368 fentichlor 4.58 µM -2.93367378894789 0.0021050292877825 no 3331 0.00167488032548861 4779 7329 A pesticide.
SGTC_2785 7756463 72.73 µM -2.9441024325352 0.00203893995547152 no 3332 0.00161946390765959 4768 2201551
SGTC_1529 apigenin 74 µM -2.95446190840457 0.00197515902564165 no 3333 0.00156607408439246 4790 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2324 6149169 200 µM -2.96712942036831 0.00189963281135363 no 3334 0.00150297200072724 4788 2888231
SGTC_1341 1486-1360 280 µM -2.97291818311743 0.00186600073519236 no 3335 0.00147491535423386 4797 3976547
SGTC_939 1165-0479 45.3 µM -2.97776432242437 0.00183826241975517 no 3336 0.00145179579421077 4773 1377347
SGTC_515 4092-1064 102 µM -3.02459945936199 0.0015888785256857 no 3337 0.00124481299012297 4757 717353
SGTC_2802 7925815 54.55 µM -3.04218943028656 0.00150347695012546 no 3338 0.00117432019894146 4775 1262923
SGTC_1926 methyl fluorone black 53.6 µM -3.06073426743714 0.00141799190530574 no 3339 0.00110397478710398 4625 72721 Reacts with homocysteine.
SGTC_452 diindolylmethane 8 µM -3.14335167684157 0.00108851131079657 no 3340 0.0008351251949783 4795 3071 Inhibits expression of several cancer promoting factors.
SGTC_57 miconazole 162.5 nM -3.16176185303671 0.00102539200654076 no 3341 0.000784088776707284 4722 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2533 agelasine 13.65 µM -3.18274463717468 0.000957557605925119 yes 3342 0.000729431083743515 4789 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1072 oxiconazole 14.9 nM -3.23768628699008 0.000798988570762936 yes 3343 0.000602516190437791 4785 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1977 st070720 65.3 µM -3.28092921472883 0.000691593213194537 yes 3344 0.00051732853527238 4802 682188
SGTC_365 0121-0052 13.6 µM -3.36879573089268 0.000513187331490599 yes 3345 0.000377486788559272 4783 3101739
SGTC_3061 glucosamine 200 µM -3.50411215213824 0.000319862363318315 yes 3346 0.00022906618613112 4769 91431 and experimental redox chemotherapeutic
SGTC_2788 5282734 71.43 µM -3.64984838677257 0.000188797807175028 yes 3347 0.000131197569080646 4794 743706
SGTC_36 0335-0881 14.2 µM -3.69698819384712 0.000158558588509297 yes 3348 0.000109086242279914 4793 23828853
SGTC_372 0155-0182 15.9 µM -3.70212752476103 0.00015555119879246 yes 3349 0.000106899551308328 4714 771486
SGTC_959 1222-0044 107 µM -3.75294087172795 0.000128558431566392 yes 3350 8.73860448674344e-05 4804 6083612
SGTC_3153 9100258 49.47 µM -3.7982022998703 0.000108276463025811 yes 3351 7.28746733918683e-05 4788 25236848
SGTC_500 h-89 112 µM -3.86750631708538 8.29520627762502e-05 yes 3352 5.49769905273851e-05 4808 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_64 000l-0018 272.079 µM -3.96171012268712 5.73553758530442e-05 yes 3353 3.72074263719901e-05 4788 6811119
SGTC_42 0133-0086 60.653 µM -3.97509032993389 5.43919102049737e-05 yes 3354 3.517627436439e-05 4791 162923 Model of phenazepam hydroxylation.
SGTC_58 0957-0393 9 µM -4.48103671976069 6.5062750165921e-06 yes 3355 3.71406643099088e-06 4663 6997992
SGTC_443 clozapine 122 µM -4.6105388501276 3.64129273186317e-06 yes 3356 2.00813286147259e-06 4809 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1