SGTCid condition conc unit YBR099C|YBR099C.score YBR099C|YBR099C.strain.pval YBR099C|YBR099C.strain.significant YBR099C|YBR099C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1082 camptothecin 424.86 nM 20.6684449871925 7.36719742958939e-111 yes 1 3.33142687178499e-95 3 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_268 camptothecin 39.6153 µM 14.7465764215574 1.79429623393862e-57 yes 2 1.6183630668879e-49 2 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_244 nsc-207895 1.295 µM 10.9493319124216 1.3953002216172e-32 yes 3 3.34697520068448e-28 3 42640
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 9.79459406609449 1.86157861485516e-26 yes 4 5.93867673370564e-23 14 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1707 st032323 6.317 µM 9.07349058955039 5.67670058434753e-23 yes 5 5.76319793623085e-20 11 3132057 YMR211W DML1
SGTC_248 streptozotocin 5.23457 mM 8.77248810220224 1.352245477478e-21 yes 6 8.73804942729461e-19 3 5300 DNA alkylating agent.
SGTC_1845 st056753 3.01 µM 7.14473242155482 6.15115978817125e-15 yes 7 4.50856826611625e-13 6 5375839
SGTC_2856 9022925 19.48 µM 6.55749329842043 7.33017750703604e-13 yes 8 2.73598844714046e-11 3 4944862
SGTC_73 0327-0325 16.231 µM 6.30316184464862 5.13875795370181e-12 yes 9 1.45817039551431e-10 13 53298
SGTC_1746 st038117 42 µM 5.72363773981017 3.29343199965472e-10 yes 10 5.21334788937358e-09 8 2898218
SGTC_974 1326-0144 138 µM 5.57343651252126 9.09274996233257e-10 yes 11 1.24881349930009e-08 13 5411856
SGTC_362 0310-0100 9.03 µM 5.00352439840428 3.39241184895557e-08 yes 12 2.81457688485523e-07 11 790235
SGTC_2859 9028643 45.46 µM 4.81575734131069 1.03091259785027e-07 yes 13 7.33213204135175e-07 6 17151580
SGTC_1770 st043884 66.3 µM 4.67289770894299 2.33804510610585e-07 yes 14 1.48489847768537e-06 7 670149
SGTC_782 0083-0095 30.5 µM 4.65937988166968 2.52338675245429e-07 yes 15 1.58581704258945e-06 14 3591729 An indicator and reagent.
SGTC_1460 k062-0059 9.15 µM 4.46570358593964 7.35883320539177e-07 yes 16 3.99030201927845e-06 5 1373085
SGTC_1079 idarubicin 2.36 µM 4.41536071093866 9.65201538323217e-07 yes 17 5.0420847742347e-06 15 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2126 5251174 33.877 µM 4.3827214574039 1.1490380721112e-06 yes 18 5.86029628479842e-06 19 790722
SGTC_1290 0986-0249 10.2 µM 4.17129063778389 3.45287672261475e-06 yes 19 1.51439629243355e-05 20 53329
SGTC_1015 4130-4525 82 µM 4.17093518541535 3.45912307920193e-06 yes 20 1.51676070956213e-05 17 1363237
SGTC_2360 9040895 200 µM 4.06122933175445 6.00180075785628e-06 yes 21 2.44074952014745e-05 14 4914414
SGTC_778 3456-2434 196 µM 3.91062115436477 1.25103124446793e-05 yes 22 4.60295345739565e-05 76 5539063
SGTC_2671 danthron 100 µM 3.83865826500562 1.76111971518976e-05 yes 23 6.18542325604747e-05 46 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2259 7964009 200 µM 3.79748555587172 2.13615128920322e-05 yes 24 7.30856456220946e-05 36 313134
SGTC_1357 1503-1303 39.5 µM 3.78218891449549 2.29388753166447e-05 yes 25 7.77276542822409e-05 37 292895
SGTC_775 4577-0580 57.3 µM 3.78152505101002 2.30097727679577e-05 yes 26 7.79352665837197e-05 10 2006902
SGTC_1457 k015-0032 57.3 µM 3.73628271037096 2.83624716338603e-05 yes 27 9.33803437982529e-05 43 4302660
SGTC_1272 0839-0021 27 µM 3.72818814609703 2.94368036582363e-05 yes 28 9.64306871464318e-05 25 5027250
SGTC_265 mycophenolic acid 32.932 µM 3.62959537932617 4.60268179665747e-05 yes 29 0.000141932915076437 29 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1731 st035964 63 µM 3.62944721909297 4.60573690211607e-05 yes 30 0.000142014398423677 42 6739575
SGTC_829 1635-0120 117 µM 3.57478336869626 5.87350256188872e-05 yes 31 0.00017525899948618 55 285054
SGTC_1410 3909-8106 77.9 µM 3.49779303833843 8.22578449861551e-05 yes 32 0.000234562512379614 15 1039210
SGTC_2116 5511452 16.8835 µM 3.43214242247403 0.000109057217117 yes 33 0.000299416494349622 30 870744
SGTC_2455 5377712 9.75 µM 3.36168428607369 0.000146822293922446 yes 34 0.000387343216028354 38 2243908
SGTC_858 0438-0351 2.77 µM 3.35270968195259 0.000152429671422078 yes 35 0.000400122996144553 41 2799119
SGTC_1915 st067105 30.6 µM 3.3524702784821 0.000152581962591256 yes 36 0.000400469203286524 74 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_784 4579-0127 173 µM 3.31584281618086 0.000177635649160745 yes 37 0.000456836012820208 46 1948547
SGTC_558 k064-0027 21.3 µM 3.29707610884662 0.000191915743417493 yes 38 0.000488485116272994 53 5088526
SGTC_2023 5144124 124 µM 3.29207252026107 0.000195900393661139 yes 39 0.000497259815041126 44 2830192
SGTC_604 1000-0114 314 µM 3.28528031919262 0.000201433210756165 yes 40 0.000509404776253669 52 1572745
SGTC_116 0155-0182 31.788 µM 3.18686032312871 0.00029986041859408 yes 41 0.000719131069313703 143 771486
SGTC_2121 5257820 149.641 µM 3.17170866692461 0.000318498785204841 yes 42 0.00075772475812587 34 791256
SGTC_1974 st069448 26.9 µM 3.10869851532959 0.000408168721713833 yes 43 0.000939566798870688 55 6323587 YNR016C ACC1
SGTC_1298 1079-1278 263 µM 3.09687686247069 0.000427406018300849 yes 44 0.000977855471483804 49 2840950
SGTC_322 k048-0136 19.3 µM 3.09140135921557 0.000436598234359621 yes 45 0.000996070795663738 38 6823282
SGTC_3024 9090631 49.47 µM 3.06512655207991 0.000483313170784461 yes 46 0.00108788955408756 24 25236383
SGTC_2612 dictamnine 15.46 µM 3.037132567343 0.000538148030616997 yes 47 0.00119420195142587 92 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1044 1222-0021 1.78 µM 3.03196875413531 0.000548871105434367 yes 48 0.00121482176236492 83 4306703
SGTC_1784 st039334 36.3 µM 3.02120785562139 0.000571854772634382 yes 49 0.00125884232203319 58 3496984
SGTC_2910 7948405 25.97 µM 3.02066248151522 0.000573042965013231 yes 50 0.00126111170713304 57 2971328
SGTC_720 r052-1644 49.9 µM 3.01845143812635 0.000577883524781876 yes 51 0.00127035058844602 62 1422863 YOR257W CDC31
SGTC_1686 st019653 115.5 µM 3.00360688904367 0.000611373359902887 yes 52 0.00133399905461513 35 97252
SGTC_788 1182-0090 188 µM 2.9979419487327 0.000624619588550245 yes 53 0.00135904721158014 142 5715185
SGTC_1971 st069429 63.5 µM 2.96471914707064 0.000707787374918041 yes 54 0.00151479687553518 46 1246522 YGL099W LSG1
SGTC_1027 k015-0025 8.67 µM 2.94586353729886 0.000759416789803494 yes 55 0.00161027224661004 73 3598955
SGTC_2283 7944793 200 µM 2.93008923929923 0.000805250549345905 yes 56 0.0016943233632672 97 2970533
SGTC_917 harmaline 728.087 nM 2.92400342671251 0.000823604156242173 yes 57 0.00172780471312705 78 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2472 5377652 49.4 µM 2.87427080967765 0.000988650093305008 yes 58 0.00202480783073666 127 1610903
SGTC_2211 7117706 200 µM 2.87408589923578 0.000989316741342294 yes 59 0.00202599370761231 51 822771
SGTC_213 1246-0773 967 nM 2.82921143459825 0.00116386081457732 no 60 0.00233314298285222 81 6251622
SGTC_321 4534-3890 65.3 µM 2.82783448134753 0.0011696374210088 no 61 0.00234320149751568 33 699746
SGTC_889 0919-1524 82.7 µM 2.80086089940128 0.00128822460422969 no 62 0.00254832413027131 59 3905452
SGTC_1140 3229-1848 2.98 µM 2.79147432602086 0.00133200487507057 no 63 0.00262342599757799 45 2849525
SGTC_25 0118-0223 35.662 µM 2.68405931714137 0.00193927544782111 no 64 0.00363671001816242 84 5333628
SGTC_1976 st070609 63.5 µM 2.64270832566484 0.00223353136504731 no 65 0.00411229259136496 76 682556
SGTC_3254 9136651 49.47 µM 2.64209831284806 0.00223815994364273 no 66 0.00411970676761311 80 16454030
SGTC_915 methyl methanesulfonate (MMS) 110 mM 2.61899281754341 0.00242000558612318 no 67 0.00440949021640613 122 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3247 9135149 49.47 µM 2.61056050900346 0.00248963067546844 no 68 0.00451969894739372 81 8934436 YOR116C RPO31
SGTC_670 4204-0025 119 µM 2.59819378168356 0.00259502093041656 no 69 0.00468577951587421 113 719039
SGTC_540 1187-0821 17.3 µM 2.59082599886291 0.00265970986393515 no 70 0.00478729443219872 102 847520
SGTC_1718 roemerine 11.9335 µM 2.57758131444267 0.00277967020254208 no 71 0.00497472346354074 163 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2445 5742597 35.57 µM 2.56172006254723 0.00292974043701892 no 72 0.00520776164182872 111 1774255
SGTC_2751 anetholtrithion 17.25 µM 2.5428215896825 0.0031180570570907 no 73 0.00549806798840686 128 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1629 st005085 44.9 µM 2.53502149128558 0.00319890921572676 no 74 0.00562202137820322 139 24207091
SGTC_2125 5246583 200 µM 2.53078754326204 0.00324358179774974 no 75 0.0056903379958471 154 835267
SGTC_2528 xanthyletin 44.79 µM 2.51853822363968 0.00337600247956277 no 76 0.00589215460295817 100 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.50037085171035 0.00358135547578999 no 77 0.00620316793813202 116 5393153
SGTC_2771 fluoxetine 41.05 µM 2.48750874643808 0.00373344830876643 no 78 0.00643206451609825 105 3386 A selective serotonin reuptake inhibitor.
SGTC_3251 9135047 49.47 µM 2.47019338706804 0.00394734273494062 no 79 0.00675200136890973 63 17682963
SGTC_1430 4049-0248 69.1 µM 2.46995343048017 0.00395038246481686 no 80 0.00675653212204072 128 22774488
SGTC_512 prima-1 270 µM 2.43620310909265 0.00439939511186902 no 81 0.00742117395914567 106 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1834 st055981 52.8 µM 2.43493155451968 0.00441716950339018 no 82 0.00744730341328864 133 471719 YDL150W RPC53
SGTC_2073 5212005 126 µM 2.42552041015278 0.00455072981126336 no 83 0.00764322808279601 67 691789
SGTC_273 hydroxyurea 18.1 mM 2.41517333569357 0.00470172319169289 no 84 0.00786386153631914 155 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_395 anisomycin 6.25 µM 2.41306333856531 0.00473305712636338 no 85 0.00790953514109531 78 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_885 0865-0106 16.8 µM 2.40073637419441 0.00491986551836321 no 86 0.00818105973533781 160 2793380
SGTC_546 peri-Naphthalide 147 µM 2.38449137128933 0.00517607191602571 no 87 0.00855137454150261 118 223824 A penicillin ester.
SGTC_922 1866-0035 480 µM 2.37761972731961 0.00528797437104268 no 88 0.00871239260314466 217 3156169
SGTC_2258 7960471 200 µM 2.37081659354517 0.00540087567963457 no 89 0.00887441800204864 100 2974708
SGTC_941 3237-0776 460 µM 2.36590347411246 0.00548373873090605 no 90 0.00899306655881779 133 760008
SGTC_1878 temozolomide 1 mM 2.34881553034878 0.00578080427044764 no 91 0.00941661735451383 98 5394 DNA alkylating agent.
SGTC_2368 9071271 200 µM 2.33774715181768 0.0059807619678036 no 92 0.00970018429301788 166 27209959
SGTC_247 mechlorethamine 29.705 µM 2.31702785231747 0.0063716106913962 no 93 0.0102511072974491 110 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2506 ethyl hematommate 54.16 µM 2.31073737652194 0.00649466611829429 no 94 0.0104236827002889 128 3940691 An allergen.
SGTC_2643 anethole 100 µM 2.3055399776885 0.00659791978049544 no 95 0.0105681752310908 149 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1309 pyrazolanthrone 13.4 µM 2.28606903702197 0.00699775622130418 no 96 0.0111251100269425 145 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_679 0422-0091 41.4 µM 2.28340376656492 0.00705411961863518 no 97 0.0112032978030282 187 627384 YHR062C RPP1
SGTC_1830 st055982 50.3 µM 2.28244093636477 0.00707457921115889 no 98 0.0112316604057116 142 455313 An antimicrobial agent.
SGTC_824 1304-0008 100 µM 2.28243714399987 0.00707465990017003 no 99 0.0112317722427243 177 768245
SGTC_1738 st035555 74 µM 2.26601369475211 0.00743180647949895 no 100 0.0117252723866342 184 5331140
SGTC_590 k048-0076 22.4 µM 2.26334759608194 0.00749125875347675 no 101 0.0118071352121878 130 6832814
SGTC_624 k048-0052 28 µM 2.26180963778858 0.00752574444256832 no 102 0.0118545835695473 153 6835531
SGTC_2994 9053520 71.4286 µM 2.24548289655697 0.00790054964432903 no 103 0.0123685745047313 147 4647384
SGTC_269 exalamide 29 µM 2.23795742965842 0.00807876806774025 no 104 0.0126119156756997 118 3316 A derivative of salicylamide.
SGTC_1519 esterone 74 µM 2.22693770123693 0.00834611173334927 no 105 0.0129757188515872 170 698 A steroid.
SGTC_1303 1160-0052 261 µM 2.21590383760832 0.00862155007178187 no 106 0.0133490443330302 150 3562476
SGTC_1253 0550-0034 176 µM 2.21452708792422 0.00865647130352772 no 107 0.0133962707161493 156 5969915
SGTC_1808 st050063 61.5 µM 2.20931431326804 0.00878981978339171 no 108 0.0135763931553998 142 4011993
SGTC_420 mitomycin C 81.9 mM 2.20420381478038 0.00892229650149552 no 109 0.0137550068109673 173 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2322 7413319 38.22 µM 2.19507025348072 0.00916342230420128 no 110 0.0140792793171997 358 1840400
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 2.19429491731893 0.00918415143391948 no 111 0.0141071073094484 183 3256 An antibiotic and ribosome inhibitor.
SGTC_1475 4092-1048 11.7 µM 2.19277434075211 0.00922492428071254 no 112 0.0141618207619625 217 2881759
SGTC_2411 st077133 39.94 µM 2.17143506097184 0.00981405221700802 no 113 0.0149491505035749 220 1403142 YNL221C POP1
SGTC_1787 fluconazole 80 µM 2.1705088296406 0.00984035114069911 no 114 0.0149841602337224 255 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2237 6667747 47.222 µM 2.16717415474172 0.00993554448675566 no 115 0.0151107886505213 149 729940 YDL015C TSC13
SGTC_2077 5212015 200 µM 2.16670912225123 0.00994888321585009 no 116 0.0151285202928002 212 780900
SGTC_623 k072-0108 16.9 µM 2.16155148768643 0.0100978733035586 no 117 0.0153263821105147 184 5382803
SGTC_404 fumagillin 50 µM 2.15993253703594 0.0101450401382539 no 118 0.0153889462534355 191 12015870 A methionine aminopeptidase binder.
SGTC_695 3505-6186 243 µM 2.15331451038706 0.0103398554996314 no 119 0.0156469845817683 174 1819379
SGTC_997 3996-0078 137 µM 2.15236594420705 0.010368044084173 no 120 0.0156842718763656 202 735687
SGTC_3341 9147222 25.867 µM 2.15155221870845 0.0103922789641179 no 121 0.0157163194253808 157 1939759
SGTC_704 1310-0270 142 µM 2.15060823399315 0.010420455161837 no 122 0.0157535674348363 207 5718033
SGTC_818 4072-2707 53.5 µM 2.14579815453311 0.0105650635498926 no 123 0.0159445429739475 154 882871
SGTC_1435 4092-0789 56.7 µM 2.13530058849436 0.0108867421501049 no 124 0.0163682324466018 152 2248285
SGTC_1076 itraconazole 331 nM 2.12948634894018 0.0110685508359978 no 125 0.0166070215604603 184 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 2.11972197513596 0.0113798226505976 no 126 0.0170147493292249 251 551469
SGTC_163 TUB2.036 7.546 µM 2.11644903944156 0.0114858467930812 no 127 0.0171533175179419 371 15992207 YJR013W GPI14
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 2.11336369701553 0.0115865785926616 no 128 0.0172848253354179 188 2333 A French combination drug.
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 2.11181762178881 0.0116373435093824 no 129 0.0173510476213315 186 165521
SGTC_685 1278-0033 54.9 µM 2.1007066381999 0.0120078822997687 no 130 0.0178333631257029 203 3590572
SGTC_1994 st072947 40.9 µM 2.09620053232146 0.0121610470164741 no 131 0.018032202878794 186 5286565 YDL195W SEC31
SGTC_2229 7354935 190 µM 2.09455110575571 0.0122175336803887 no 132 0.0181054577619723 119 318112
SGTC_1832 st054113 55 µM 2.09173025080895 0.0123146643808172 no 133 0.018231326415246 140 1251267
SGTC_3133 9127736 49.47 µM 2.08762777532254 0.0124571188983798 no 134 0.0184157122493508 178 27243420
SGTC_2610 ononetin 44.17 µM 2.0556492081255 0.0136172743106607 no 135 0.0199081705026628 278 259632
SGTC_935 2996-0153 430 µM 2.055463089316 0.013624290626597 no 136 0.0199171486285473 176 23738523
SGTC_1740 st038286 13.222 µM 2.04846047744989 0.0138905518568511 no 137 0.0202574504481239 227 716786
SGTC_1449 4112-4002 201 µM 2.02354791116111 0.0148744957884155 no 138 0.0215083445868704 182 2059539
SGTC_769 0302-0231 76 µM 2.01985922941269 0.0150251613026417 no 139 0.0216989956718956 293 571869 YER009W NTF2
SGTC_2682 pyrogallin 40.03 µM 2.01827752130213 0.0150901674495071 no 140 0.0217811832243031 256 822798 An ATP competetive kinase inhibitor.
SGTC_3062 9077494 49.47 µM 2.01445941261246 0.015248083366863 no 141 0.0219806610145957 223 16459633
SGTC_2876 9059903 25.97 µM 1.98666546128876 0.0164409795568988 no 142 0.0234797408587294 201 6916095
SGTC_937 3122-0005 46.7 µM 1.98613472502605 0.0164645146167439 no 143 0.0235091832069549 244 759535
SGTC_3111 9122088 49.47 µM 1.98373466494696 0.0165713037413663 no 144 0.0236427134977867 127 16876704
SGTC_2399 5884133 200 µM 1.98030733067144 0.0167248281265741 no 145 0.0238345027915417 281 722445
SGTC_1833 st055984 71 µM 1.97619555938581 0.0169106153192892 no 146 0.0240663163250651 210 676288
SGTC_141 0443-0274 32.331 µM 1.97012498608102 0.0171881340425489 no 147 0.0244120239859088 362 1627241
SGTC_3210 9128157 49.47 µM 1.96362896121674 0.0174894033838936 no 148 0.0247865681429287 281 17590849
SGTC_1425 4048-4433 7.33 µM 1.94421570031393 0.0184167471129294 no 149 0.0259347226314914 250 23734946
SGTC_1969 st069479 40.1 µM 1.94055343340754 0.0185963048097846 no 150 0.026156233514519 191 3895485
SGTC_1142 3253-1408 9.78 µM 1.92544620640098 0.0193528348475971 no 151 0.0270867798350631 225 256655
SGTC_1847 st056231 15 µM 1.92438902769213 0.0194067408775624 no 152 0.0271529193729013 297 5393180
SGTC_1226 3909-7979 35.4 µM 1.90437324773364 0.0204516779889893 no 153 0.0284307953923646 287 6615510
SGTC_2738 aclarubicin 5.55 µM 1.90254463222354 0.0205494755986318 no 154 0.0285499948580155 160 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2532 xanthone 78.9 µM 1.90210500942207 0.0205730463939188 no 155 0.0285787138520175 243 7020 An insecticide.
SGTC_1785 bathophenanthroline 24 µM 1.89424762251814 0.0209982059695064 no 156 0.0290960748442074 292 72812 An iron chelator.
SGTC_2477 5967686 25.23 µM 1.88432044695157 0.0215459709956703 no 157 0.0297608216449596 264 776118
SGTC_2616 abietic acid 100 µM 1.8753872926197 0.0220491636829065 no 158 0.030369731019406 277 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_847 0342-0274 5.54 µM 1.87180441484175 0.0222537514358124 no 159 0.0306168336362194 259 18097
SGTC_1824 st053723 68.6 µM 1.86959326637112 0.0223808088443588 no 160 0.0307701605340654 266 675225
SGTC_943 3253-1379 105 µM 1.86046176825531 0.0229120244921464 no 161 0.0314101113379216 269 668464
SGTC_3231 9132313 49.47 µM 1.85452358670787 0.0232631407087463 no 162 0.0318321444485244 232 4905967
SGTC_2002 4023503 131 µM 1.8492914001012 0.0235762553544012 no 163 0.0322078734395398 354 4736863 YCR052W RSC6
SGTC_2686 alizarin 95.37 µM 1.83847490976297 0.0242348051726595 no 164 0.0329962278538743 268 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2492 derrusnin 100 µM 1.83648996552038 0.0243573186709262 no 165 0.033142612410136 199 1715307 Part of coumarin class of compounds.
SGTC_1186 1319-0216 26 µM 1.83369265666492 0.0245308548731362 no 166 0.0333498146436066 275 4565136
SGTC_892 0929-0076 29 µM 1.8313658563461 0.0246759916474742 no 167 0.0335229769963933 336 5751038
SGTC_1353 1498-1206 8.11 µM 1.82687804704337 0.0249579589843592 no 168 0.0338590538396529 339 6756808
SGTC_1773 st048542 73.5835 µM 1.82514629156199 0.0250674845055193 no 169 0.0339894780689058 306 3237138
SGTC_106 0092-0003 11.579 µM 1.82428454996902 0.0251221356250197 no 170 0.0340545324664423 204 1072148
SGTC_2182 6325192 200 µM 1.82327933841618 0.025186011672611 no 171 0.0341305470015505 236 736248
SGTC_875 0709-0210 25.7 µM 1.81568031082251 0.0256733078512306 no 172 0.0347097130259125 322 6251364
SGTC_1273 0849-0096 14.1 µM 1.81245721085599 0.0258823635784551 no 173 0.0349577898869781 280 5286025
SGTC_3049 9092223 49.47 µM 1.8124025369393 0.0258859220707637 no 174 0.0349620105709599 251 8623917
SGTC_219 mitoxanthrone 164.414 µM 1.79620889070222 0.026958063760218 no 175 0.0362306506391486 305 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1783 st039459 87.517 µM 1.79385011020959 0.0271172830983432 no 176 0.0364185481299155 329 729761
SGTC_833 3852-0053 558 µM 1.78875130674984 0.0274641383611458 no 177 0.0368274380275069 310 3123681
SGTC_3044 9093193 49.47 µM 1.78517050691707 0.0277099334966806 no 178 0.0371168321395737 328 25236277
SGTC_2074 5212007 75.395 µM 1.77451637391063 0.028452123959404 no 179 0.0379888880637924 232 758611
SGTC_674 0498-0004 451 µM 1.76508108424926 0.0291231465266464 no 180 0.0387750696277289 320 4231473
SGTC_2220 6782180 200 µM 1.7620390127173 0.0293422767449328 no 181 0.0390313531256411 181 833803
SGTC_1514 1189-1591 158 µM 1.7606129266092 0.0294454727245548 no 182 0.0391519696198383 367 767698 YMR146C TIF34
SGTC_978 1416-0512 87.4 µM 1.7560187349177 0.0297799734977561 no 183 0.0395426048208778 336 6814003
SGTC_1897 st060201 15 µM 1.75574971198808 0.0297996582345822 no 184 0.0395655772183698 266 611878
SGTC_1285 0929-0069 65.5 µM 1.75365588071883 0.0299532356733544 no 185 0.0397447448226994 306 1206237
SGTC_1311 1190-0148 100 µM 1.75288477301195 0.0300099596818057 no 186 0.0398108939144345 371 1961333
SGTC_156 3474-0145 5.642 µM 1.74801461894897 0.0303702779301872 no 187 0.0402307480221089 324 2265471
SGTC_2130 NSC 7 2.4545 µM 1.74640579474161 0.030490091583182 no 188 0.0403702318715458 324 21448
SGTC_2414 st077232 92.9 µM 1.7446955952155 0.0306178840187451 no 189 0.0405189352281951 312 729801
SGTC_1626 st003712 1.76 µM 1.74461250783229 0.0306241038971794 no 190 0.0405261710609283 287 24207035
SGTC_745 0469-0705 296 µM 1.74027470541123 0.0309502858536688 no 191 0.0409053966865746 359 3486736
SGTC_496 calpeptin 138 µM 1.73779438504349 0.0311380825777169 no 192 0.0411235252048124 283 73364 A calpain inhibitor.
SGTC_3294 9122953 26.2835 µM 1.73438924956834 0.0313974358838376 no 193 0.0414245206239031 308 16459826
SGTC_933 2914-0560 114 µM 1.72994038303163 0.031738973954864 no 194 0.0418204636284315 348 463887
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.72929088220735 0.0317890917620626 no 195 0.0418785238333901 285 756377
SGTC_56 0957-0365 83.25 µM 1.72214707112609 0.0323446601581303 no 196 0.0425214400131442 348 6752360
SGTC_1930 st074634 34.3 µM 1.71988046202406 0.0325225979262266 no 197 0.0427270863537843 332 684253 YOR116C RPO31
SGTC_942 3253-1115 227 µM 1.71796779939003 0.0326733769653208 no 198 0.0429012444143044 322 46497897
SGTC_1167 k781-0610 148 µM 1.71699410286348 0.0327503565638015 no 199 0.0429901247405349 358 4525169
SGTC_2311 7694451 200 µM 1.71221893805613 0.0331300447886246 no 200 0.0434281643403378 329 2163142
SGTC_2708 st078559 56 µM 1.7106971629352 0.0332518051714522 no 201 0.0435685158555623 216 17250902
SGTC_3033 9090887 49.47 µM 1.70411598862565 0.033782629513852 no 202 0.0441797100813801 368 19325384
SGTC_2493 resveratrol 26.09 µM 1.70370941351439 0.0338156504164233 no 203 0.0442176943055823 243 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1250 0485-0349 40.2 µM 1.69832351621832 0.034255589101656 no 204 0.0447233593350504 347 6842794 YDL195W SEC31
SGTC_2780 5215298 71.43 µM 1.69768415541444 0.034308125285072 no 205 0.0447836949114014 369 2834131
SGTC_2076 5212012 200 µM 1.6965563831455 0.0344009555787004 no 206 0.0448902809448318 226 604802
SGTC_608 k048-0125 159 µM 1.69292949041312 0.0347008960619559 no 207 0.0452344445862741 333 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_2358 9037157 4 µM 1.6882868320099 0.0350879699946557 no 208 0.0456780908630996 334 2388925
SGTC_1476 4112-3294 3.34 µM 1.68664142136818 0.0352260008610333 no 209 0.0458361610804717 316 704369
SGTC_964 1287-0107 19.4 µM 1.68451910329862 0.0354046962172076 no 210 0.0460406953628251 368 51516812 YPR165W RHO1
SGTC_2750 bromebric acid 70.15 µM 1.67914573437597 0.03586044965061 no 211 0.0465618224153304 391 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2052 5265182 7.135 µM 1.67446782537229 0.0362611196404419 no 212 0.0470193463159408 342 1239884
SGTC_1307 1187-1599 12.2 µM 1.67177157785263 0.0364937173941515 no 213 0.0472846867137264 314 1538471
SGTC_683 panaxydol 45 µM 1.66843187088013 0.0367835157601791 no 214 0.0476150129506272 353 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_477 mead ethanolamide 10 µM 1.66765940902954 0.0368508123450445 no 215 0.0476916787728588 169 16061185
SGTC_2269 7935389 174.42 µM 1.66556495037075 0.03703378746626 no 216 0.0479000485164744 334 97605
SGTC_1506 4226-2149 212 µM 1.65962805751506 0.0375564825863749 no 217 0.0484946501617107 403 991114
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.64185700293749 0.0391571756645131 no 218 0.0503098212018422 371 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_3197 9113331 49.47 µM 1.6414076985671 0.0391983546677155 no 219 0.0503564064364337 380 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_548 1436-0017 110 µM 1.63533685083912 0.0397582144916376 no 220 0.0509892262525195 421 9677137
SGTC_2391 6285546 200 µM 1.61720412281181 0.0414692372049141 no 221 0.0529171133492908 394 846083
SGTC_1880 MG-132 525 µM 1.60936242801626 0.04222744151747 no 222 0.0537685578950679 320 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1975 st070967 30.8 µM 1.60928454367146 0.042235027945481 no 223 0.0537770686052644 410 261391
SGTC_3280 9140961 49.47 µM 1.60829153605925 0.0423318498681624 no 224 0.053885671752085 315 4901226
SGTC_3027 9089541 49.47 µM 1.60519849753013 0.0426345837949274 no 225 0.0542250640136665 393 9943819
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.60142213934824 0.0430065688644359 no 226 0.0546417262012232 358 4213774
SGTC_2971 9092186 9.93 µM 1.59967146618528 0.04317990392752 no 227 0.0548357425232749 343 25236400
SGTC_1605 st000082 49.1 µM 1.59727875065491 0.0434177200714675 no 228 0.055101792641856 338 1114022
SGTC_2063 5246145 200 µM 1.59722273284283 0.0434233004210763 no 229 0.0551080335531602 393 711240
SGTC_2946 9065502 71.43 µM 1.59706055432483 0.0434394594905328 no 230 0.0551261049146141 219 16489101
SGTC_1370 2001-0092 44.6 µM 1.59448659698342 0.0436965727822732 no 231 0.0554135451772379 441 790957
SGTC_1664 st014217 9.02 µM 1.5895556128461 0.044192558897614 no 232 0.055967504517753 377 3982782
SGTC_717 1532-0246 73.2 µM 1.58891130437964 0.0442577009933885 no 233 0.0560402093315442 397 9561992
SGTC_2416 tofa 880 nM 1.5861181545119 0.0445409948661236 no 234 0.0563562546688276 383 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_862 0452-0056 10.2 µM 1.58515670776299 0.0446388464318007 no 235 0.0564653669739189 345 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1893 st059353 36.1 µM 1.58497599249245 0.0446572581056562 no 236 0.05648589449553 401 3112488
SGTC_3322 9139058 2.11 µM 1.58364470808986 0.0447930808868114 no 237 0.0566372969279015 370 4908926 YPR165W RHO1
SGTC_2124 5246320 200 µM 1.58132485163413 0.0450305562890575 no 238 0.0569018900757486 378 579342
SGTC_2604 4'-hydroxychalcone 11.32 µM 1.57611803567403 0.0455672492718526 no 239 0.0574993016393243 364 5282362
SGTC_2356 9061756 188.97 µM 1.57356516483409 0.0458322592515437 no 240 0.0577940059922253 332 20104043
SGTC_846 0335-0850 148 µM 1.56876305984089 0.046334114491424 no 241 0.0583515794095374 343 6819598
SGTC_2449 5812982 45.77 µM 1.56169052984442 0.0470812697065836 no 242 0.0591804554156628 336 776185
SGTC_1996 st072960 66.8 µM 1.55790030576929 0.0474856337727053 no 243 0.0596284413659148 386 1719405
SGTC_1496 4469-0713 57.4 µM 1.55770682060538 0.0475063503537559 no 244 0.0596513814628091 386 746691
SGTC_386 1509-0011 3.07 µM 1.55421926263099 0.0478810083717742 no 245 0.0600660621281789 501 3107280
SGTC_1562 morin hydrate 59.1 µM 1.55324851800555 0.0479857123591663 no 246 0.0601818871307448 390 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1641 st009299 47.1 µM 1.54747957593535 0.0486117332722281 no 247 0.0608738228546446 306 4046054
SGTC_41 0478-0632 82.643 µM 1.54724469071214 0.0486373596951402 no 248 0.0609021265865988 464 3750424
SGTC_202 3594-0513 34.79 µM 1.54723503317463 0.0486384135818886 no 249 0.0609032905426253 335 708429
SGTC_2522 biochanin a 4.94 µM 1.54586164716855 0.0487884714524635 no 250 0.0610689924108014 358 5280373 A possible chelator.
SGTC_3224 9130643 49.47 µM 1.54237028992369 0.0491716076715739 no 251 0.0614918184935855 397 17644395
SGTC_1468 k284-1086 134 µM 1.53891142989978 0.0495535434174979 no 252 0.0619129601961844 482 15996457
SGTC_2296 7971656 126.45 µM 1.53875355484052 0.049571032707299 no 253 0.0619322362329182 425 666570
SGTC_1469 k284-2957 126 µM 1.52904188829697 0.0506563895866265 no 254 0.0631270299781553 364 23884841
SGTC_1144 3486-0183 12.5 µM 1.52874873284409 0.0506894440281708 no 255 0.0631633730670966 431 6744069
SGTC_3262 9137218 49.47 µM 1.52422663907253 0.0512015073612749 no 256 0.0637260528301818 228 17650664
SGTC_235 0330-0087 5 mM 1.52216413470026 0.0514364195435758 no 257 0.063983979635812 432 46494818 YHR062C RPP1
SGTC_821 1114-0266 29.2 µM 1.52182198150572 0.0514754723845123 no 258 0.0640268460491219 394 3123235
SGTC_29 0299-0004 12.984 µM 1.52044799237649 0.051632534920837 no 259 0.0641992101848001 308 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1069 diphenylcyclopropenone 8.49 µM 1.51972792122353 0.0517149992460246 no 260 0.0642896855700557 483 65057 A dermal irritant. YDR527W RBA50
SGTC_2499 avocadenofuran 51.48 µM 1.51293936547374 0.0524975973221681 no 261 0.0651475307137919 450 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_648 0375-0473 33.3 µM 1.51021991814614 0.052813725714455 no 262 0.0654936589413261 451 1713139
SGTC_1693 xanthone 101.9 µM 1.50776477308347 0.0531004251227002 no 263 0.0658073705013601 426 7020 An insecticide.
SGTC_377 3970-0964 33.1 µM 1.50230313992903 0.0537426328303392 no 264 0.066509419058002 521 16481235
SGTC_2333 9017922 200 µM 1.50022881345778 0.0539881489137712 no 265 0.0667775709853552 417 3163164
SGTC_3299 9121982 43.1275 µM 1.49961157184211 0.0540613764341293 no 266 0.0668575242074025 430 17594604 YPL160W CDC60
SGTC_1050 3232-1156 69.3 µM 1.4993455442472 0.0540929613087264 no 267 0.0668920064174809 437 700529
SGTC_793 0488-0545 106 µM 1.49921811290226 0.0541080961264634 no 268 0.0669085288039227 423 292548
SGTC_2327 6189656 200 µM 1.49081241706268 0.0551138503310734 no 269 0.0680053754018862 384 5349088
SGTC_1084 voriconazole 435 nM 1.49067784717678 0.0551300711237272 no 270 0.0680230474573592 416 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3002 9075603 71.4286 µM 1.48933529637098 0.0552921061674662 no 271 0.0681995487916917 440 20105405
SGTC_2993 9054257 71.4286 µM 1.48603840118423 0.0556916107961769 no 272 0.0686344819622204 463 6470217 YGL055W OLE1
SGTC_3328 9140624 29.0385 µM 1.48254215023299 0.0561177577794626 no 273 0.069098048432827 430 4904392
SGTC_1284 0929-0043 16 µM 1.47616149117448 0.056902100735388 no 274 0.0699502723022823 460 1239883
SGTC_2973 9094665 17.96 µM 1.4752008573191 0.057020930802607 no 275 0.0700792755242664 488 25237061 YIL048W NEO1
SGTC_1161 k007-0610 110 µM 1.4724341757137 0.0573642601519741 no 276 0.0704518350066349 555 5843850
SGTC_1445 4239-0156 97.7 µM 1.46839945480886 0.0578678590104659 no 277 0.0709978748026145 500 4008346
SGTC_3096 9117468 49.47 µM 1.46805409661904 0.0579111263060451 no 278 0.0710447645314405 326 41316311
SGTC_1165 k072-0275 30.3 µM 1.46538830895681 0.0582459587482858 no 279 0.0714075026419814 422 6153523 YGL055W OLE1
SGTC_982 1491-0518 27.5 µM 1.46373902920598 0.0584538744836972 no 280 0.0716326335807715 405 3091256
SGTC_566 0958-0068 16.5 µM 1.45910555890703 0.0590411103064132 no 281 0.0722680282377763 382 6815365
SGTC_1105 epirubicin 18.1 µM 1.45898617005304 0.059056302321372 no 282 0.0722844571035624 434 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1019 4262-0212 3.4 µM 1.45731758724983 0.0592689475111043 no 283 0.0725143671364705 536 4677213
SGTC_1073 triclabendazole 3.09 µM 1.45628137493061 0.0594013049290256 no 284 0.0726574260454167 516 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_205 1486-1330 71.903 µM 1.45625221122475 0.059405033415793 no 285 0.0726614554957245 363 4118834
SGTC_2640 pentamidine 10.38 µM 1.45611590039815 0.0594224627529845 no 286 0.0726802913695383 491 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1941 st076221 61.8 µM 1.45561484102951 0.0594865649904671 no 287 0.0727495615199935 519 2828568
SGTC_3327 9140648 26.9345 µM 1.45530896048936 0.0595257239695589 no 288 0.0727918735495768 423 8029710
SGTC_1655 st012546 55.1 µM 1.45473692245194 0.0595990107836182 no 289 0.0728710533396231 413 720985 YLR208W SEC13
SGTC_2809 7964133 12.99 µM 1.4506147390204 0.0601292180676046 no 290 0.0734435843951132 478 1253665
SGTC_3261 9137475 49.47 µM 1.44303614217907 0.0611136276265828 no 291 0.0745051451385297 239 17027690
SGTC_1034 k072-0165 12.7 µM 1.44190321968642 0.0612618628719825 no 292 0.0746648388989967 475 5835461
SGTC_2513 baicalein 25.65 µM 1.43828281042458 0.0617374528260336 no 293 0.075176913572687 452 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_3103 9120822 49.47 µM 1.4375473704631 0.0618344141668899 no 294 0.0752812614711883 479 17141819
SGTC_45 0kpi-0036 14.9 µM 1.43664322262429 0.0619537810148314 no 295 0.0754096977559492 422 2795021
SGTC_2471 5466956 24.79 µM 1.43547414411802 0.0621083908675807 no 296 0.0755760155486791 416 724419
SGTC_1776 st049249 45.9 µM 1.43302533050514 0.06243322034744 no 297 0.0759252992616297 475 1822314
SGTC_2138 5575593 77.673 µM 1.43211789917459 0.0625539248487341 no 298 0.0760550413678147 377 762213
SGTC_2398 5228213 48.84 µM 1.42936357970545 0.0629214125948927 no 299 0.0764498803099933 557 80771 YMR134W ERG29
SGTC_2113 5491891 107.031 µM 1.42513633377429 0.0634886904358206 no 300 0.0770588978077993 480 789979
SGTC_1474 0330-0125 5.35 µM 1.42332740350879 0.0637326536678783 no 301 0.0773206332772676 451 X1474
SGTC_1139 k015-0024 46.9 µM 1.41710940475601 0.0645768152283626 no 302 0.0782254716530978 436 2766652
SGTC_1120 ficusin 1.78878 µM 1.41519335946985 0.0648386824323099 no 303 0.0785059054968805 472 6199 A DNA cross-linker.
SGTC_21 0849-0113 22.993 µM 1.40990551568783 0.0655656536105416 no 304 0.0792837919051162 490 1560156
SGTC_3107 9121808 49.47 µM 1.40897283864822 0.0656945309578624 no 305 0.0794215998612584 360 662681
SGTC_2767 sibutramine 71.45 µM 1.40661620522987 0.0660210456633521 no 306 0.0797706125740706 478 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2795 7780010 54.55 µM 1.40649057759588 0.0660384867769745 no 307 0.0797892502942108 440 953673
SGTC_1609 st001574 46.4 µM 1.40413719254523 0.0663658717220718 no 308 0.0801390001327006 480 3960012
SGTC_2955 9076254 12.21 µM 1.40411710784537 0.0663686711506875 no 309 0.0801419900127341 430 16459619
SGTC_3028 9087778 49.47 µM 1.4025364591636 0.0665892706717933 no 310 0.0803775555434708 441 17217395
SGTC_356 1634-0012 32.5 µM 1.40137971207964 0.0667510686909343 no 311 0.0805502778932384 521 735457
SGTC_9 0092-0002 10.449 µM 1.39950954504804 0.0670132983830596 no 312 0.080830119025009 488 759368
SGTC_550 4123-0385 25.7 µM 1.39367037386668 0.0678371800437301 no 313 0.0817085832679525 473 5731123
SGTC_2620 irigenin 100 µM 1.39267863153715 0.067977884458291 no 314 0.0818584965838392 514 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1794 st048918 76.9 µM 1.39247891027984 0.0680062473474909 no 315 0.0818887118208129 387 672303
SGTC_1867 st057372 64 µM 1.39011775007127 0.0683422542140106 no 316 0.0822465620531354 484 688837
SGTC_1640 st009078 66.4 µM 1.38808607948095 0.0686323968959349 no 317 0.0825554174655349 420 690618
SGTC_1188 1403-0014 4.57 µM 1.38238217813351 0.0694520485779049 no 318 0.083427192657446 564 9614867
SGTC_211 3455-0679 143.504 µM 1.37864758393198 0.0699927808147577 no 319 0.0840017188964258 507 748649
SGTC_773 4358-1457 44.6 µM 1.3761023108459 0.0703631632903533 no 320 0.0843949801122283 555 1186886
SGTC_1163 k060-0048 49.9 µM 1.37600054095476 0.0703780038914106 no 321 0.084410732894462 542 6809982
SGTC_600 1495-0418 41.6 µM 1.37599037560314 0.0703794863866709 no 322 0.0844123064925199 478 5377768
SGTC_2057 5236571 38.335 µM 1.37395088769036 0.0706774073138736 no 323 0.0847284649496028 540 54684039 YBR257W POP4
SGTC_3306 9127676 59.7925 µM 1.37265589949372 0.070867076900875 no 324 0.0849296725640769 469 41905287
SGTC_2583 asiatic acid 100 µM 1.37085161989151 0.0711319911443185 no 325 0.0852106077749679 467 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2657 nystatin 74.44 µM 1.36939992335326 0.0713456887177837 no 326 0.0854371491063176 519 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2473 5854593 8.94 µM 1.36872339964047 0.0714454448460616 no 327 0.0855428765044831 461 2872951
SGTC_2225 6654152 15.4 µM 1.36798872329028 0.071553897017576 no 328 0.0856578029584772 404 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2747 doxorubicin 7.63 µM 1.36612165164591 0.0718300806326567 no 329 0.0859503917458152 318 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2825 7998094 58.44 µM 1.36049389299255 0.072667504829139 no 330 0.0868368420743302 500 2987815
SGTC_992 3909-8734 162 µM 1.359583416106 0.0728036858265749 no 331 0.0869808945198987 499 4288319
SGTC_1777 st045864 34.765 µM 1.35912884253808 0.0728717499683069 no 332 0.0870528823225523 506 4691462
SGTC_2223 6903751 107.57 µM 1.3543792072459 0.073585838062573 no 333 0.0878077138852167 434 5598863
SGTC_464 bw-b 70c 158 µM 1.35124271520091 0.0740603217962693 no 334 0.0883088477847488 551 5353454
SGTC_1812 st052057 4.327 µM 1.35021818268175 0.0742158168888335 no 335 0.088473003726221 530 3645418
SGTC_2761 levamisole 97.89 µM 1.34911940153928 0.0743828577962411 no 336 0.0886493087132308 501 26879 An alkaline phosphatase inhibitor.
SGTC_2564 betulinic acid 100 µM 1.34362641043818 0.0752222306977187 no 337 0.0895346123697393 576 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_3076 9116187 49.47 µM 1.3402874573991 0.0757359668643558 no 338 0.0900759538101359 467 27241210
SGTC_2487 5918373 44.05 µM 1.34021919848911 0.0757464970866463 no 339 0.0900870458747191 533 2876279
SGTC_3039 9090270 49.47 µM 1.33985414532205 0.0758028323439986 no 340 0.0901463841966953 473 17173750
SGTC_1561 5-methoxyflavone 52.9 µM 1.335845717381 0.0764235163387608 no 341 0.0907998532554368 438 94525
SGTC_945 3381-0768 11.3 µM 1.33176183236446 0.0770598532893934 no 342 0.0914692318274304 543 1126236 YIL048W NEO1
SGTC_1047 2043-3044 82 µM 1.33111334930772 0.0771612670876504 no 343 0.0915758585677715 532 669592
SGTC_1932 st074806 40.9 µM 1.33013445521815 0.0773145446467199 no 344 0.0917369875163625 577 17251235
SGTC_980 1473-0395 201 µM 1.32948731691654 0.0774160020211188 no 345 0.091843623713427 460 768876
SGTC_1672 st016598 6.51 µM 1.32928986047101 0.0774469790724109 no 346 0.0918761790885448 543 4665860 YNL267W PIK1
SGTC_2648 atorvastatin 78.68 µM 1.32918672427868 0.0774631628643281 no 347 0.091893186932022 490 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_59 0330-0160 1.33 µM 1.32701125263109 0.0778051294462176 no 348 0.0922524801884608 681 4293482
SGTC_2208 7283366 200 µM 1.32561710966224 0.0780248791236709 no 349 0.0924832779927082 532 898663
SGTC_280 3448-3607 3.04 µM 1.32529594194282 0.0780755693698466 no 350 0.0925365072101824 506 626179
SGTC_1511 0906-3109 28.5 µM 1.32026784907271 0.0788724193231707 no 351 0.0933728029657893 638 2882180
SGTC_2491 paeonol 100 µM 1.31504699903561 0.0797063216154766 no 352 0.0942470537468299 466 11092 Increases levels of cortical cytochrome oxidase.
SGTC_108 0509-0257 621.132 µM 1.30822610256533 0.0808058191490643 no 353 0.0953983155408402 584 536624
SGTC_272 doxorubicin 8.13 µM 1.30796574362672 0.0808480135973668 no 354 0.0954424643170989 601 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_664 1222-0054 14.9 µM 1.30794897424697 0.0808507318568554 no 355 0.0954453083976353 560 6813991
SGTC_2353 9059630 146.67 µM 1.30066471835535 0.0820380211722329 no 356 0.0966866219486976 508 4779114
SGTC_284 0988-0104 32.6 µM 1.29383447798764 0.083163197931157 no 357 0.0978613003393751 579 4666532
SGTC_285 1486-1325 46 µM 1.29259520010664 0.0833685877254803 no 358 0.0980755502916653 583 22310230
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.2897540499768 0.0838409001007658 no 359 0.0985680333001476 526 6708760
SGTC_1972 st070201 17.4 µM 1.28950646765181 0.0838821531527747 no 360 0.0986110346505185 566 2829099
SGTC_1700 st030840 7.9285 µM 1.28903190051109 0.0839612698378267 no 361 0.0986934982571569 602 5499307
SGTC_2285 7945142 200 µM 1.28391280014365 0.0848182575416179 no 362 0.0995862340041131 540 2970608
SGTC_605 1315-0399 119 µM 1.2828332514805 0.0849998190797827 no 363 0.0997752509486743 612 24020461
SGTC_170 4197-0004 226 µM 1.28008685803514 0.0854630283304919 no 364 0.100257295041205 493 218692
SGTC_3214 9129694 49.47 µM 1.27576239299413 0.0861962248718683 no 365 0.101019762634997 515 17158655
SGTC_1684 st024538 14.6195 µM 1.27161280477107 0.0869041854962498 no 366 0.101755362455287 562 6732859
SGTC_2866 9034245 58.44 µM 1.26904146762202 0.0873450555966068 no 367 0.102213137297999 499 6462273
SGTC_3257 9139206 32.98 µM 1.26778600300322 0.0875609176601839 no 368 0.102437191008481 495 4910041
SGTC_1685 st024049 53.0905 µM 1.26741016146757 0.0876256164609165 no 369 0.102504334139736 523 1941139
SGTC_2340 7987427 183.45 µM 1.26308666507861 0.0883724467439646 no 370 0.10327901787638 564 2239331
SGTC_1936 st074407 74.3 µM 1.25920728714469 0.089046589330287 no 371 0.103977735076692 612 809813
SGTC_2141 5621638 7.665 µM 1.25551002856372 0.0896926392550293 no 372 0.104646834925883 559 2856238
SGTC_1692 fluoroquinolonic acid 71 µM 1.25480399434847 0.089816405227306 no 373 0.104774961113224 561 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1529 apigenin 74 µM 1.25196970824696 0.0903145260575143 no 374 0.105290451021561 612 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.25196404166518 0.0903155240002445 no 375 0.105291483474035 629 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_257 daunorubicin 18.5 µM 1.24777879510071 0.0910548271846182 no 376 0.106056038113208 549 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2457 5731572 11.68 µM 1.24584836080602 0.0913973376585228 no 377 0.106410035589346 582 2865357
SGTC_661 1304-0007 33.6 µM 1.24095728468617 0.0922694186475341 no 378 0.107310764507824 568 3117130
SGTC_3144 9087057 49.47 µM 1.23739042232934 0.0929092644702517 no 379 0.107971086397503 581 17249618
SGTC_119 0121-0043 24.815 µM 1.23706188929199 0.0929683633399817 no 380 0.108032053510773 761 1092378
SGTC_2988 9073640 71.4286 µM 1.22661239345724 0.0948626195792162 no 381 0.109984154418531 557 9102229
SGTC_3249 9135183 49.47 µM 1.22428688923792 0.0952880225228558 no 382 0.110422010524468 640 4902779
SGTC_1358 1509-0022 2.48 µM 1.21883575732029 0.0962906963002045 no 383 0.111453268426654 608 3258434
SGTC_1382 3002-2117 298 µM 1.21748667847685 0.0965400368065551 no 384 0.11170955094607 646 1497314
SGTC_991 3996-0057 64.7 µM 1.21741498212238 0.0965533011880811 no 385 0.111723182784352 603 715343
SGTC_3040 9091894 49.47 µM 1.21580923136863 0.0968507284086167 no 386 0.112028800704495 530 25236966
SGTC_1635 st007035 42.4 µM 1.21326961401116 0.0973225047581849 no 387 0.112513378163101 789 3716403
SGTC_3157 9099274 49.47 µM 1.21120773567606 0.0977067714921947 no 388 0.112907899374664 566 17217662
SGTC_99 0109-0120 622.8 µM 1.20964746467536 0.0979982935417062 no 389 0.113207098352539 564 759414
SGTC_2964 9083345 53.42 µM 1.20867765481605 0.0981798143673165 no 390 0.113393354798883 560 17741579
SGTC_712 r015-0009 80.6 µM 1.20710163061767 0.0984753264504993 no 391 0.113696503498946 556 6813872 YLR060W FRS1
SGTC_1616 st002734 56.1 µM 1.20666478336235 0.0985573525611586 no 392 0.113780633357192 637 4026101
SGTC_3326 9140064 16.379 µM 1.20515691235301 0.0988408673766922 no 393 0.114071366273012 593 1868434
SGTC_2099 5377090 177.372 µM 1.20247125965878 0.0993473097246771 no 394 0.114590497393272 616 2243829
SGTC_132 0417-1715 25.805 µM 1.20038205370487 0.0997425880853424 no 395 0.114995497725798 650 6769098
SGTC_203 k066-0004 30.888 µM 1.19959203420494 0.0998923589930577 no 396 0.115148910882726 731 6795412
SGTC_2508 celastrol 40.54 µM 1.19901254005354 0.100002323153414 no 397 0.115261534794693 557 122724 Celastrol is a natural product and antioxidant.
SGTC_743 1275-0778 158 µM 1.19870185776923 0.100061314262266 no 398 0.115321947713705 657 2849257 YMR203W TOM40
SGTC_2185 6113692 200 µM 1.19819752841749 0.100157128394296 no 399 0.115420063685855 570 874150
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.19627663306151 0.100522679731158 no 400 0.115794312145423 597 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1730 st033808 45.1 µM 1.19285387201466 0.101176450699944 no 401 0.116463303697206 703 1045166
SGTC_2608 thymoquinone 42.66 µM 1.18809090361786 0.102091358603986 no 402 0.117398798858828 576 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1372 2752-0194 270 µM 1.18763216684028 0.102179793093413 no 403 0.117489179539321 579 823334
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.18733770286949 0.102236588711145 no 404 0.117547221017058 608 75037 A free radical scavenger.
SGTC_523 1934-0222 13.7 µM 1.18716846125904 0.102269242081978 no 405 0.117580589234335 636 1361595
SGTC_1925 st057770 10.1 µM 1.18437455277571 0.102809393694486 no 406 0.118132414445671 573 5989122
SGTC_1113 artemisinin 1.17947 µM 1.18244279556059 0.1031840742464 no 407 0.118515025452785 668 2240 An anti-malaria and mitochondrial poison.
SGTC_100 0086-0128 49.5915 µM 1.17608231264886 0.104424749064425 no 408 0.119780992562303 693 93297
SGTC_1312 1218-2183 165 µM 1.17593596995791 0.104453421309241 no 409 0.119810231864986 669 6744073
SGTC_2585 alliin 100 µM 1.1749382901062 0.104649044107592 no 410 0.120009702631987 656 87310 A garlic compound which reacts with lipids.
SGTC_927 2425-1185 123 µM 1.17200160747224 0.105226402003566 no 411 0.120598205387753 622 730375
SGTC_905 2-aminofluorene 215 µM 1.16777379333011 0.106061641315352 no 412 0.121449010857948 694 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1248 0469-0687 58.6 µM 1.16710367267891 0.1061944677143 no 413 0.121584252436301 657 4017482
SGTC_551 k048-0028 34.9 µM 1.16393008694446 0.106825144680011 no 414 0.122226172762033 710 6836383
SGTC_2646 retinol 96.75 µM 1.16244986427202 0.107120227252305 no 415 0.122526389252454 645 445354 A vitamin A analog and teratogen.
SGTC_52 0329-0193 875 nM 1.15960962217854 0.107688075034783 no 416 0.123103890800586 645 3739292
SGTC_1374 2889-5571 141 µM 1.15910769410744 0.107788650265586 no 417 0.123206145018602 692 2853281
SGTC_2685 mycophenolic acid 18.85 µM 1.15767377221805 0.108076349057571 no 418 0.123498595541531 615 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_576 1073-0113 22.7 µM 1.15592445373086 0.108428076402683 no 419 0.12385602962785 839 5439563
SGTC_789 1309-1135 70.6 µM 1.15301376886313 0.109015138239432 no 420 0.124452366543473 655 3092424
SGTC_2095 5432005 200 µM 1.15044367118835 0.109535402638852 no 421 0.124980590956088 617 783734
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.14908260889989 0.109811643261125 no 422 0.125260959403238 746 368090
SGTC_2723 salbutamol 83.58 µM 1.14613322373131 0.110411964189042 no 423 0.125870016261749 558 9884233 β2-adrenoceptor agonist
SGTC_475 α-linolenic acid 10 µM 1.14529101035047 0.110583820277875 no 424 0.126044314309514 696 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_574 1315-0397 40 µM 1.14220579100522 0.111215005699826 no 425 0.126684244710108 761 6794277
SGTC_237 nikkomycin 200 µM 1.14170383252804 0.111317941680317 no 426 0.126788573617041 693 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1602 st001878 87.6 µM 1.14049677671841 0.111565750207927 no 427 0.127039697403539 666 595405 YLR310C CDC25
SGTC_1645 Cervolide 78 µM 1.13580321117163 0.112533090131709 no 428 0.128019466424204 640 23173 A fragrance.
SGTC_3182 9108849 49.47 µM 1.13506514719669 0.112685747977918 no 429 0.128174011621624 694 17133045
SGTC_1179 1021-1431 9.29 µM 1.13485579105242 0.112729077176078 no 430 0.128217872846757 715 2840958
SGTC_1642 st009582 77.7 µM 1.1344961867298 0.112803530112157 no 431 0.128293236189901 634 6739311
SGTC_161 4065-0411 162.148 µM 1.13221058971385 0.113277563779876 no 432 0.128772954521624 725 1906281 YLR208W SEC13
SGTC_1112 tnp00069 1.16933 µM 1.1313858202371 0.113448969699325 no 433 0.128946368523753 741 145826
SGTC_3330 9141424 71.43 µM 1.12973554371768 0.113792489944179 no 434 0.129293837683077 719 27261020
SGTC_686 1319-0111 510 µM 1.12576540255953 0.11462194668768 no 435 0.130132416026515 728 4562600
SGTC_2799 7812892 81.82 µM 1.12375725042165 0.115043132094665 no 436 0.13055801083267 724 20205235
SGTC_2784 7567673 72.73 µM 1.1189705521102 0.116051518868505 no 437 0.13157635108566 723 3471247
SGTC_2692 st077426 47.7 µM 1.11742145871877 0.116379197481826 no 438 0.13190708212285 709 25238571
SGTC_157 1348-1695 65.819 µM 1.11716112189643 0.116434330703635 no 439 0.131962720200515 731 5380510
SGTC_2192 5915882 198.485 µM 1.11576498868118 0.116730315018596 no 440 0.132261371991194 634 2876149
SGTC_2204 7233102 200 µM 1.11292186064409 0.117334714831913 no 441 0.132870995190788 619 2172480
SGTC_2556 citropten 84.59 µM 1.11087709620278 0.11777076433659 no 442 0.133310627693637 738 2775 A potential DNA crosslinker.
SGTC_681 1642-0006 26.6 µM 1.10972092556147 0.118017826617415 no 443 0.133559651421589 685 4446530
SGTC_3292 9120825 59.784 µM 1.10779420374427 0.118430362224082 no 444 0.133975351955705 713 24824900
SGTC_148 3253-0744 288.01 µM 1.10775635965162 0.118438475318889 no 445 0.133983525914338 674 6893655
SGTC_3296 9122258 64.045 µM 1.10657722185964 0.118691458148213 no 446 0.134238379981124 688 4730474
SGTC_338 4055-0136 114 µM 1.10395130844578 0.119256216400047 no 447 0.13480713003457 696 2900563
SGTC_454 lyso-paf C-16 6.67 µM 1.1034737129415 0.119359136930509 no 448 0.134910750511558 664 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_179 1273-0063 6.77 µM 1.10109087160632 0.119873569195961 no 449 0.135428554766512 639 3108139
SGTC_1980 st071811 45.7 µM 1.09549379629796 0.121088065816464 no 450 0.136650180946443 701 4974850
SGTC_1948 st076329 66.6 µM 1.0939045312069 0.121434489253084 no 451 0.13699842562764 659 24208413
SGTC_2524 avocatin b 10.57 µM 1.09317315302369 0.121594146854852 no 452 0.137158891060536 656 6710748
SGTC_495 decylubiquinone 155 µM 1.09259163013997 0.121721196750827 no 453 0.137286569617635 677 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_734 2023-0417 80 µM 1.09000218323319 0.122288066026114 no 454 0.137856091173824 701 3935732
SGTC_617 3770-0098 35 µM 1.08812980525477 0.122699110765672 no 455 0.138268903747121 679 5962639
SGTC_2958 9077254 16.72 µM 1.08718268554172 0.122907401457212 no 456 0.138478040617054 675 16457351
SGTC_2996 9066192 71.4286 µM 1.08682770817306 0.122985531964636 no 457 0.138556479938912 690 6472854
SGTC_1087 pterostilbene 9.05 µM 1.08670791585657 0.123011906105857 no 458 0.138582957268398 748 5281727 Similar to reservatol, lowers cholesterol.
SGTC_351 caspofungin 25 nM 1.08419837607585 0.123565332069865 no 459 0.139138425772139 846 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2307 7538926 6.34 µM 1.08369257788242 0.123677085985876 no 460 0.139250563780769 723 96582
SGTC_2345 9052315 157.45 µM 1.08298468579894 0.123833610474055 no 461 0.139407610263899 697 6469265
SGTC_3314 9135860 59.4275 µM 1.08252378186936 0.123935597054306 no 462 0.139509926945835 749 25252478
SGTC_198 3454-2873 16.191 µM 1.08056587163638 0.124369489104297 no 463 0.139945135287822 713 710957
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.0798104170798 0.124537188904016 no 464 0.140113305710669 687 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_35 0133-0054 64.071 µM 1.07971133448074 0.124559195504839 no 465 0.140135372495489 663 99677
SGTC_1379 2144-0755 36.5 µM 1.07622947215685 0.125334256438959 no 466 0.140912320969064 784 5392327
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.07570877773127 0.125450451536688 no 467 0.141028760261723 702 688662
SGTC_357 1325-0123 420 µM 1.07350019403053 0.125944141751708 no 468 0.141523375828172 702 1098503
SGTC_135 0933-0004 26.348 µM 1.07136789806304 0.126422063053917 no 469 0.142002020591509 685 21230617 YGL099W LSG1
SGTC_1094 duloxetine 25.4 µM 1.07080102882245 0.126549330397454 no 470 0.142129452117048 722 60834 A selective serotonin reuptake inhibitor.
SGTC_1349 flufenamic acid 69 µM 1.07014050485639 0.126697736629184 no 471 0.142278034719067 713 3371 A non-steroidal anti-inflammatory.
SGTC_1721 st082152 9.2685 µM 1.07000602702979 0.126727965890681 no 472 0.14230829791738 678 5296051
SGTC_361 000s-0510 1.45 µM 1.06740012817838 0.127314737492946 no 473 0.142895595306037 725 660
SGTC_956 1185-0240 191 µM 1.06711088107613 0.12737998374876 no 474 0.142960884442508 706 1416193
SGTC_2158 5657123 3.6195 µM 1.06555119289981 0.127732207640739 no 475 0.14331328614802 741 2858827
SGTC_762 1165-0429 115 µM 1.06434387491197 0.12800532030184 no 476 0.14358647449949 736 5967793
SGTC_2091 4-phenylthiadiazole 200 µM 1.06408508981983 0.128063913964608 no 477 0.143645077341396 755 270010
SGTC_1401 3807-4679 7.6 µM 1.06213582884635 0.128505860892333 no 478 0.144087013376568 709 3291456
SGTC_91 0417-1751 58.384 µM 1.06034784467516 0.128912172117934 no 479 0.144493190150437 853 6795624
SGTC_998 3996-0085 177 µM 1.05839318928968 0.129357377122367 no 480 0.144938111588811 811 715391
SGTC_444 curcumin 90.4 µM 1.05243321312979 0.130721432971645 no 481 0.146300418612829 768 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_96 0929-0093 37.281 µM 1.05131254850674 0.130979025305612 no 482 0.146557532825995 713 6991579
SGTC_2827 7993847 71.43 µM 1.05055328101113 0.131153747249791 no 483 0.146731903897024 679 2985692
SGTC_2860 9025725 38.96 µM 1.04940216702162 0.131418947495906 no 484 0.146996530636024 706 40546248
SGTC_2256 7954252 200 µM 1.0467637258041 0.132028202827122 no 485 0.147604282170432 645 2972920
SGTC_1407 3909-7909 12.3 µM 1.04233885300133 0.133054338732606 no 486 0.148627302517029 793 4411780
SGTC_1088 bifonazole 369 nM 1.04176562929817 0.133187670884171 no 487 0.148760176486204 749 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_955 1216-0110 33 µM 1.04145220722255 0.133260611900487 no 488 0.148832861677257 760 3619719
SGTC_1154 4088-0362 150 µM 1.03846862034014 0.1339563420989 no 489 0.149525968528235 815 6618304
SGTC_849 0386-0493 241 µM 1.03561583859508 0.134623900871671 no 490 0.150190699927158 741 726119
SGTC_1038 k292-0204 154 µM 1.03181187948937 0.135517584560986 no 491 0.151080126549201 714 4454212
SGTC_1473 k844-0725 134 µM 1.03144242043047 0.135604599558854 no 492 0.151166698347846 845 54682906
SGTC_1751 st044839 27.194 µM 1.03141067401287 0.135612078260594 no 493 0.151174138720929 767 5291326
SGTC_1857 st056007 79.3 µM 1.03139570034483 0.1356156057991 no 494 0.151177648167644 752 619834
SGTC_215 1287-0124 461.5 µM 1.02670170528373 0.136724529849065 no 495 0.152280473035637 762 5560863
SGTC_281 1672-3440 14.9 µM 1.02643062525718 0.136788759442314 no 496 0.152344324307342 829 6833000
SGTC_1074 carmofur 3.8 µM 1.02636011382148 0.136805469773551 no 497 0.152360935764451 843 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1764 st044502 93.5 µM 1.01950252469872 0.138437302714945 no 498 0.15398222759197 779 8407
SGTC_2379 9035213 200 µM 1.01858850227034 0.138655801351662 no 499 0.15419918253555 846 646551
SGTC_3017 9080681 49.47 µM 1.01835439400159 0.138711803108147 no 500 0.154254783642869 765 16451914
SGTC_1347 1493-0251 600 nM 1.01551233860159 0.139392888743209 no 501 0.154930833985301 858 3986378
SGTC_97 0535-0701 19.132 µM 1.01482105063041 0.139558896156092 no 502 0.1550955686754 740 2832013 YGL099W LSG1
SGTC_1196 1588-0294 184 µM 1.01438206459075 0.139664385001599 no 503 0.155200239552023 738 6144269
SGTC_2140 5586273 200 µM 1.01377698594082 0.139809874936066 no 504 0.155344589605258 744 854421
SGTC_2277 7947813 106.88 µM 1.0135196870201 0.139871773147655 no 505 0.155405998734972 748 1246798
SGTC_2132 5317594 122.667 µM 1.01139658789066 0.140383236458906 no 506 0.155913326810029 728 794577
SGTC_882 0843-0131 351 µM 1.00859486344878 0.141060124911733 no 507 0.156584485877454 842 5425421
SGTC_2016 5121758 140 µM 1.00856218705645 0.141068032468549 no 508 0.156592324781355 842 2795203
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.00851811975848 0.141078697055233 no 509 0.156602896715959 760 364106
SGTC_634 1611-4317 11.2 µM 1.00730180725256 0.141373268793479 no 510 0.156894880785676 863 2843522
SGTC_12 0849-0099 9.267 µM 1.00673741401325 0.141510097448068 no 511 0.157030488797803 785 6071388
SGTC_1392 3455-1037 33.9 µM 1.00613464260031 0.141656329377708 no 512 0.157175403132016 786 981132
SGTC_2232 chlorophetanol 41.5365 µM 1.00246881219263 0.142547861223657 no 513 0.158058611065609 923 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1874 staurosporine 7.6 µM 1.00147854043488 0.142789345396363 no 514 0.158297754915003 827 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1610 st001799 48.1 µM 0.999280774743564 0.143326272183258 no 515 0.158829347971753 729 621897
SGTC_1929 genistein trimethyl ether 50.5 µM 0.998703014414184 0.143467648379251 no 516 0.158969289991432 812 136420
SGTC_2486 5283202 22.39 µM 0.997372557556484 0.143793565041285 no 517 0.159291853299043 751 1377751
SGTC_2148 5546263 113.568 µM 0.992646477612587 0.144955330303514 no 518 0.160441133210006 795 792097
SGTC_1040 k898-0338 155 µM 0.991930450272602 0.145131893855212 no 519 0.160615726920293 875 20969351
SGTC_2913 7966556 36.57 µM 0.988211931126325 0.146051161962771 no 520 0.161524433059889 802 2976516
SGTC_2217 6934799 96.0675 µM 0.98646013897977 0.146485581202437 no 521 0.161953683217591 830 675606
SGTC_3095 9117207 49.47 µM 0.985486155672658 0.146727489858738 no 522 0.162192664231025 763 17015229
SGTC_916 4466-0038 42 nM 0.983788733976838 0.147149719505856 no 523 0.162609699895103 934 5722064 YGL116W CDC20
SGTC_1487 3970-0795 2.82 µM 0.983754309413935 0.147158290953802 no 524 0.162618164798562 840 3765103
SGTC_2110 5483698 200 µM 0.983197240143442 0.147297043396662 no 525 0.162755186423868 806 2848765 YHR062C RPP1
SGTC_2705 st078069 42.8 µM 0.982620086536117 0.147440890814762 no 526 0.162897227345185 751 1530061
SGTC_1361 1608-0041 5.61 µM 0.982427452012021 0.147488923204275 no 527 0.162944653777843 828 X1361
SGTC_536 3852-0578 10.6 µM 0.982043643300274 0.147584655105774 no 528 0.163039173868648 850 2869208
SGTC_2115 tiliquinol 12.7705 µM 0.981951581955096 0.147607623793961 no 529 0.163061850999415 808 71208 A bioactive hydroxyquinoline.
SGTC_1219 1469-0211 33.1 µM 0.978653108556122 0.148432150637556 no 530 0.163875704307938 809 6822282
SGTC_2925 9010536 32.5 µM 0.978327747253999 0.148513648516138 no 531 0.16395612535904 880 2994177
SGTC_1993 st073995 70.8 µM 0.975498656260512 0.149223552304764 no 532 0.164656483955841 839 3098394
SGTC_880 0833-0487 87.2 µM 0.972377457956258 0.150009379459506 no 533 0.165431401055395 806 76075
SGTC_2739 tacrine 100.86 µM 0.971274487996603 0.150287733912192 no 534 0.165705804757352 783 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1873 rapamycin 2 nM 0.96986688508096 0.150643467641641 no 535 0.166056424124168 864 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1484 3473-2379 286 µM 0.969777616848308 0.150666046676606 no 536 0.166078676072155 981 671917
SGTC_2939 9044578 71.43 µM 0.967547956920352 0.151230736194264 no 537 0.166635089732372 796 2653634
SGTC_2794 7785382 27.27 µM 0.966357807208764 0.151532732203319 no 538 0.166932584581548 908 2205081
SGTC_310 1273-0058 1.06 µM 0.964374665719088 0.152036836935755 no 539 0.167429059491158 972 2734232
SGTC_1574 spiramycin 23.7 µM 0.962757752959647 0.152448671494595 no 540 0.167834553234978 831 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_524 r073-0010 27.8 µM 0.962561867758688 0.152498614519887 no 541 0.167883720757278 815 2772106
SGTC_2098 5376439 882.5 nM 0.9557441914391 0.154243618881437 no 542 0.169600745071878 900 2844116
SGTC_2916 7875993 68.79 µM 0.9548924536707 0.154462547968256 no 543 0.169816043178746 844 1299250
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.954832730256267 0.15447790686648 no 544 0.169831146343785 819 5355888
SGTC_1944 st076371 56.9 µM 0.953153131794286 0.154910257775216 no 545 0.17025624455741 813 24208455
SGTC_625 k213-0058 121 µM 0.951589455801338 0.155313486415056 no 546 0.170652615561117 999 3655420
SGTC_1101 ebselen 5.29 µM 0.949697242883979 0.155802361101131 no 547 0.171133055557179 925 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1739 st037196 92.5 µM 0.947291148131681 0.156425466773366 no 548 0.171745220095938 912 612214
SGTC_3218 9131285 49.47 µM 0.942149437624356 0.15776250724302 no 549 0.173058068249441 936 17156417
SGTC_876 0720-0963 56.8 µM 0.936782784965232 0.159166024045189 no 550 0.174435151136652 902 765861
SGTC_2517 totarol 10 µM 0.932187065510026 0.160374403054052 no 551 0.175619929396468 805 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2350 9023895 38.85 µM 0.932050894844212 0.160410298399524 no 552 0.175655111853014 856 2997209
SGTC_735 3076-0345 636 µM 0.931053426843575 0.160673396573454 no 553 0.175912964120897 919 2888990
SGTC_1860 st056228 74.6 µM 0.928916836301485 0.161237904384961 no 554 0.176466093482716 846 688679
SGTC_1988 st071872 53.4 µM 0.927567920141803 0.161594966505091 no 555 0.176815872370004 906 16414116
SGTC_1385 3091-4834 14.1 µM 0.9263916303535 0.161906754321433 no 556 0.177121246055055 839 4072814
SGTC_710 3448-4187 58 µM 0.924717699855363 0.162351122217104 no 557 0.177556385030028 948 3946412
SGTC_3303 9125618 40.5795 µM 0.922300380989142 0.162994232411574 no 558 0.17818595767982 931 22695467
SGTC_2744 captopril 92.04 µM 0.92189980237249 0.16310096319328 no 559 0.178290421126717 836 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_811 0416-0114 265 µM 0.919161338471063 0.163831820103693 no 560 0.179005594916523 863 6612453
SGTC_3349 9149703 23.001 µM 0.919158469902082 0.16383258679648 no 561 0.179006345013554 907 4910494
SGTC_1620 st003704 16.5 µM 0.918132718857502 0.164106892267242 no 562 0.179274693630743 908 2834414
SGTC_2022 5136654 200 µM 0.917739428034812 0.16421214472669 no 563 0.179377650225919 860 1713771
SGTC_2288 7946289 167.31 µM 0.916311747824272 0.164594588205898 no 564 0.179751704036061 967 1246052
SGTC_1434 4073-0095 163 µM 0.911871606874698 0.165787687965153 no 565 0.180918154861282 937 24133745
SGTC_3234 9132280 49.47 µM 0.91152686175268 0.165880556935271 no 566 0.181008919438095 884 17612295
SGTC_3237 9133362 49.47 µM 0.911526081595099 0.165880767135705 no 567 0.181009124870518 897 43845137
SGTC_1276 0871-0068 94.2 µM 0.90997332138801 0.166299473608215 no 568 0.181418289808153 883 3414906
SGTC_1397 3532-0190 20.1 µM 0.907391679761893 0.166997130437882 no 569 0.18209985386439 843 5322280
SGTC_1901 st060216 58.6 µM 0.90512478829472 0.167611283964065 no 570 0.182699640634818 926 688792
SGTC_2054 5233173 129 µM 0.904209731139627 0.167859605815354 no 571 0.182942100589877 919 6889
SGTC_3060 1327-0027 12.5 µM 0.903131303322114 0.168152565949851 no 572 0.183228106018275 884 16000455 YPR107C YTH1
SGTC_2977 9011197 71.43 µM 0.903112432635118 0.168157695190112 no 573 0.183233113117138 828 2704722
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.902961496404069 0.168198724780291 no 574 0.183273165213816 784 88881 An O-methylated flavonoid and antioxidant.
SGTC_292 k038-0015 474 µM 0.900433734600968 0.168886813193108 no 575 0.183944737493622 890 46368540
SGTC_1436 4092-1007 8.32 µM 0.899660588872264 0.16909763379172 no 576 0.184150451435021 906 2881121
SGTC_3346 9158254 43.5805 µM 0.899362792552191 0.169178881656363 no 577 0.18422972546533 887 17639500
SGTC_797 k781-0471 270 µM 0.898906561232898 0.169303403998908 no 578 0.18435121642349 937 23738129
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.898602469861548 0.169386434409339 no 579 0.184432221339665 922 641818 YHR062C RPP1
SGTC_2661 dactinomycin 12.96 µM 0.897130168736491 0.169788807313769 no 580 0.184824731071988 948 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.895883498608654 0.170129995179408 no 581 0.185157494090579 904 7104
SGTC_2390 9097792 176.6 µM 0.893804718003648 0.170699890887699 no 582 0.185713192209393 868 4497149
SGTC_431 k089-0097 107 µM 0.893187465662613 0.170869345038223 no 583 0.185878394669297 942 5499420
SGTC_381 3461-2219 42.7 µM 0.8919754594797 0.171202389888355 no 584 0.186203043114151 945 2883159
SGTC_2698 st077697 67.5 µM 0.891010191440032 0.171467930767107 no 585 0.186461851393648 863 3154499
SGTC_3015 9080845 49.47 µM 0.890157986658699 0.171702587109852 no 586 0.18669053017157 990 5296973
SGTC_2502 avocadyne acetate 18.59 µM 0.889586907272799 0.171859949730979 no 587 0.186843869486064 1011 3952079
SGTC_1308 1187-1617 41.4 µM 0.887243787140657 0.17250656718014 no 588 0.187473831305825 951 2882570
SGTC_253 dyclonine 31.25 µM 0.885373332885103 0.173023857869128 no 589 0.187977655104688 979 3180 An oral anasthetic.
SGTC_230 MPP+ 141.667 µM 0.884002561406862 0.173403583666366 no 590 0.188347415069366 873 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_385 1494-0393 12.4 µM 0.883943009586844 0.173420092495586 no 591 0.188363489090623 933 3090647
SGTC_131 0141-0277 33.849 µM 0.882318822537728 0.173870731883387 no 592 0.188802210244851 924 1547771
SGTC_517 1365-0151 113 µM 0.879804114033714 0.174569918881731 no 593 0.189482717800582 901 768657
SGTC_746 1095-0025 46.6 µM 0.879098988778736 0.174766291271023 no 594 0.189673803000247 968 6749286
SGTC_1819 st053448 58.6 µM 0.879041039322402 0.174782436017318 no 595 0.189689512264374 931 2857616
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.87869882275958 0.174877797017952 no 596 0.189782298568971 904 17037758
SGTC_2694 st077685 81.9 µM 0.876923608016526 0.175373002588067 no 597 0.190264066172936 909 2838096
SGTC_1687 st020778 55.3625 µM 0.876699923810634 0.175435463492283 no 598 0.190324824083691 1017 4259299
SGTC_737 1950-0117 57.9 µM 0.875476035135899 0.175777468103951 no 599 0.190657472087508 953 5393513
SGTC_569 4130-2812 160 µM 0.874793924129882 0.175968261011168 no 600 0.190843021877555 840 743552
SGTC_1559 coumarin 343 70.1 µM 0.873695088067967 0.176275891521252 no 601 0.191142163315981 910 108770 A hepatotoxic, DNA x-linker.
SGTC_236 1509-0011 5.31 µM 0.871235006261389 0.176965849831129 no 602 0.191812924833588 1099 3107280
SGTC_2544 sphondin 68.51 µM 0.869481228370254 0.177458757514519 no 603 0.192291985549308 918 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_49 0717-0965 32.132 µM 0.868413915797175 0.177759154617964 no 604 0.192583889749753 1039 5889349 YGL099W LSG1
SGTC_43 0570-0105 72.5 µM 0.867569299478667 0.177997100685895 no 605 0.192815079593477 990 1114046 YDL195W SEC31
SGTC_1275 0867-0008 21.1 µM 0.866720890620437 0.17823631728408 no 606 0.19304747815032 952 3422836
SGTC_815 1582-0027 36.9 µM 0.866336701757214 0.178344709448814 no 607 0.193152772488681 959 3128206
SGTC_1922 5578187 25 µM 0.865447764676295 0.178595666681113 no 608 0.193396537145028 920 1350412
SGTC_1024 4507-0395 26 µM 0.865397383152668 0.178609896624863 no 609 0.193410358403339 907 4201836
SGTC_103 0844-0104 51.839 µM 0.865346411706512 0.178624293915085 no 610 0.193424342109455 1041 5375804
SGTC_1326 1431-2094 10.8 µM 0.86376241139564 0.179072071594408 no 611 0.193859210329931 923 616278
SGTC_2635 hydroquinidine 100 µM 0.86375405171858 0.179074436645538 no 612 0.193861506958305 943 442912 An experimental heart treatment.
SGTC_1713 st033146 12.748 µM 0.863682153115255 0.179094778418818 no 613 0.193881260125164 945 674619
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.861988983112428 0.179574235412286 no 614 0.194346790161582 957 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1258 0671-0043 57.1 µM 0.86156442478903 0.179694584487446 no 615 0.194463627337954 947 4298767
SGTC_1588 farnesol 29.9 µM 0.86014446030308 0.180097468320294 no 616 0.194854707829607 941 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1221 2958-7315 257 µM 0.857017871425955 0.180986566543942 no 617 0.195717503955361 913 4562705
SGTC_3016 9080866 49.47 µM 0.856767181343249 0.181057973400791 no 618 0.195786783279671 1007 17066299
SGTC_628 1636-0253 16 µM 0.855343998605038 0.181463688905395 no 619 0.196180368205052 966 4456143
SGTC_3166 9102297 49.47 µM 0.854003853999502 0.181846252049376 no 620 0.196551426985594 962 25237072
SGTC_1652 st011932 78 µM 0.853788162512309 0.181907871317327 no 621 0.196611187273378 948 1551076
SGTC_3137 9097352 49.47 µM 0.850632143733129 0.182810983353548 no 622 0.197486863933111 1009 44120435
SGTC_2421 5690543 90.72 µM 0.85030491056789 0.182904782787178 no 623 0.197577793577424 957 3397993
SGTC_667 1498-1044 59 µM 0.845115975309432 0.184396172241814 no 624 0.199023044820653 1002 6739982
SGTC_2071 5230951 39.92 µM 0.844540582872687 0.184562014650089 no 625 0.199183697756302 1060 1799272
SGTC_2352 9027995 87.8 µM 0.841906761849696 0.185322330857003 no 626 0.19992007256032 920 2997347
SGTC_626 0214-0009 33 µM 0.839668501932049 0.185969985000298 no 627 0.20054713963065 1016 3437874
SGTC_3302 9125395 16.351 µM 0.838877478392767 0.18619920769694 no 628 0.200769033590471 953 17599668
SGTC_1752 st044819 83.042 µM 0.838095424263774 0.186426003286131 no 629 0.200988556292114 953 441209 YML126C ERG13
SGTC_2378 9074213 121.43 µM 0.8380695361565 0.186433513758372 no 630 0.200995825548708 1024 657714
SGTC_588 3970-1144 52.9 µM 0.837948262589828 0.186468699272175 no 631 0.20102988068559 971 1888707
SGTC_702 1488-0190 94 µM 0.837597616721339 0.186570456490722 no 632 0.201128365907794 994 949357
SGTC_2397 5161689 200 µM 0.836477255694465 0.186895814973047 no 633 0.201443233394786 983 2259942
SGTC_1117 retinoic acid 1.10837 µM 0.835301556100116 0.187237621344555 no 634 0.201773970742467 1026 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_325 2810-4341 181 µM 0.835044123412641 0.187312515257759 no 635 0.201846432787493 1015 774970
SGTC_478 N-arachidonylglycine 10 µM 0.834312049661985 0.187525595894567 no 636 0.202052581737769 892 5283389
SGTC_2567 aureobasidin a 60 nM 0.830477560150779 0.18864412476053 no 637 0.203134414966214 959 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_665 3914-0008 307 µM 0.830255524950783 0.18870901863536 no 638 0.203197163994757 990 1069549
SGTC_2642 cholecalciferol 100 µM 0.829505232175917 0.188928407303228 no 639 0.203409288678993 996 9821465 A vitamin D precursor, similar to steriods.
SGTC_610 4215-0184 155 µM 0.828424719737889 0.189244629516147 no 640 0.203715005934485 1007 5605015
SGTC_1052 3253-3998 198 µM 0.82557922176081 0.1900789492838 no 641 0.204521412950324 1054 5450317
SGTC_790 1575-0012 79.1 µM 0.824251443697367 0.190469035341865 no 642 0.204898351051236 1045 378741 YLR208W SEC13
SGTC_912 3474-0017 2.18 µM 0.823350276605454 0.190734067783837 no 643 0.205154415257658 1012 3360550
SGTC_3069 9117009 49.47 µM 0.820213602034614 0.191658324486051 no 644 0.206047174571911 895 41904981
SGTC_3087 9117406 49.47 µM 0.819515371714459 0.191864438616676 no 645 0.206246217713199 1000 42546093
SGTC_780 0109-0199 192 µM 0.818273862582781 0.192231260948225 no 646 0.206600413634104 1068 610414
SGTC_2008 4012253 172 µM 0.817614357591035 0.192426295855005 no 647 0.206788713310724 1006 603940
SGTC_2318 6029776 164 µM 0.817583255331684 0.192435496688861 no 648 0.206797596032596 1006 818325
SGTC_2425 5628681 7.85 µM 0.816885502591212 0.192641980272349 no 649 0.206996931714028 1058 5714958
SGTC_2435 5706476 10.6 µM 0.816459444146541 0.19276812884763 no 650 0.207118705003238 1054 5725375
SGTC_850 0388-0143 75.9 µM 0.81460601018801 0.193317485849006 no 651 0.207648934537122 980 67273
SGTC_152 4469-0003 551.229 µM 0.813232483288425 0.193725214296601 no 652 0.208042389362902 1036 697280
SGTC_1246 0422-0085 105 µM 0.812459524160676 0.193954895890781 no 653 0.208264001410057 1037 264295
SGTC_2621 lithochol-11-enic acid 100 µM 0.810722099575018 0.194471769748919 no 654 0.208762639605467 1043 6708711
SGTC_1054 3429-0080 167 µM 0.808781938916905 0.195049946255602 no 655 0.209320293388079 1057 1162877
SGTC_3344 9148862 3.898 µM 0.807462284102444 0.195443805714891 no 656 0.209700097735626 1052 4905352
SGTC_1717 st033143 58.0435 µM 0.806675022811191 0.195678998783659 no 657 0.209926868975303 1041 674616
SGTC_2915 7971052 15.16 µM 0.805507801711817 0.196028020296719 no 658 0.210263353055639 903 5741558
SGTC_3043 9092303 49.47 µM 0.804729222148755 0.196261040347564 no 659 0.210487976346293 1008 25236084
SGTC_2919 7978188 46.38 µM 0.80421371569937 0.196415417959876 no 660 0.210636779468543 1043 2980291
SGTC_2174 5790901 200 µM 0.803548017406966 0.196614882050767 no 661 0.21082902738871 1005 786020
SGTC_2262 9014885 67.46 µM 0.80332165214162 0.196682736133635 no 662 0.210894423160975 992 6457424
SGTC_1208 2323-2347 50.3 µM 0.80277646181961 0.196846217778692 no 663 0.211051974681125 1046 5412760
SGTC_3162 9099653 49.47 µM 0.802614912282412 0.196894676080125 no 664 0.211098673230937 1015 25237511
SGTC_283 0987-0079 11.7 µM 0.802073503879338 0.197057129270474 no 665 0.211255220381536 1079 411556
SGTC_69 0096-0274 206.684 µM 0.801217759796368 0.19731406635035 no 666 0.211502795726386 1181 6741392
SGTC_2933 9026794 32.47 µM 0.800982389400637 0.197384771806116 no 667 0.211570920520213 1008 17586027
SGTC_1472 k841-0093 193 µM 0.799935553279257 0.197699427800482 no 668 0.211874068735274 1092 X1472
SGTC_177 1327-0068 8.361 µM 0.799015394581137 0.19797625751981 no 669 0.212140742775771 1026 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2628 lathosterol 100 µM 0.798931519452044 0.198001502987801 no 670 0.212165060641821 1081 6710616
SGTC_1432 4049-0298 68.4 µM 0.798069869710579 0.198260962405268 no 671 0.212414972585777 1047 741646
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.795926511927269 0.198907258472375 no 672 0.21303737526333 1056 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3200 9114385 49.47 µM 0.795290575851002 0.199099259062519 no 673 0.213222247141058 1026 17018030 YLR208W SEC13
SGTC_446 go6976 132 µM 0.794086189749213 0.19946319081966 no 674 0.213572628405529 1048 3501 A protein kinase C inhibitor.
SGTC_3 0833-0587 95.581 µM 0.792104148149848 0.200062979337313 no 675 0.214149975788646 1020 5382644
SGTC_2894 9048625 32.47 µM 0.789784944773383 0.200766171734955 no 676 0.214826686436835 1074 4092861
SGTC_3063 1327-0034 4 µM 0.786365929156166 0.201805533254453 no 677 0.215826568957209 1012 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1172 0370-0043 85 µM 0.783109933091267 0.202798326790929 no 678 0.216781279316109 1070 376585
SGTC_2944 9067346 25.62 µM 0.782978063753186 0.202838596772985 no 679 0.21681999690864 984 6473075
SGTC_2348 9022543 33.42 µM 0.781061215489979 0.203424499103434 no 680 0.217383245813848 1046 3162678 YDL140C RPO21
SGTC_2064 5220758 200 µM 0.779540150902098 0.20389014419244 no 681 0.217830797757617 1103 788518
SGTC_748 act1.228 77.9 µM 0.778840188113548 0.20410463777453 no 682 0.218036930423998 1055 4421505 YNR035C ARC35
SGTC_2080 5212524 12.4 µM 0.778539758952028 0.204196741203399 no 683 0.218125438554572 1046 260183
SGTC_3226 9131256 49.47 µM 0.77752872566464 0.204506878334878 no 684 0.218423446739572 980 17178073
SGTC_3260 9137109 49.47 µM 0.777224391296874 0.204600288568757 no 685 0.218513197033234 936 17478346
SGTC_1755 st041960 45.185 µM 0.776391426006977 0.204856082824119 no 686 0.218758952785164 1060 2257073
SGTC_996 3970-0799 1.8 µM 0.775403173777616 0.205159810467512 no 687 0.219050730160617 1221 6615648 YGL040C HEM2
SGTC_1568 digitonin 820 nM 0.772074661058804 0.206184756100558 no 688 0.220035104427821 1102 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_350 k064-0020 19.8 µM 0.76971529494991 0.206913108372321 no 689 0.220734397622574 1098 2790705
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.768664795349309 0.207237894029026 no 690 0.221046164563768 1096 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_642 0335-0876 158 µM 0.768341388091548 0.207337943345198 no 691 0.22114219597641 1087 6812350
SGTC_1013 4112-3890 241 µM 0.767595072094102 0.207568932735195 no 692 0.221363895497322 1014 705171
SGTC_430 0958-0115 16.4 µM 0.767025001277538 0.207745475557734 no 693 0.221533325471155 1003 6833180
SGTC_2431 5490079 200 µM 0.766963520738871 0.207764520503154 no 694 0.22155160244575 1145 5722345
SGTC_1168 k815-0004 80.5 µM 0.765668329655674 0.208165974002907 no 695 0.221936837973328 1093 642433
SGTC_2834 9001755 58.44 µM 0.764551496852681 0.208512511377076 no 696 0.222269330358951 992 2989575
SGTC_3139 9095020 49.47 µM 0.764377350233676 0.208566577241414 no 697 0.222321201164645 922 25236292
SGTC_1683 st010134 710 nM 0.76345558121535 0.208852888889504 no 698 0.222595871593517 1133 3818134
SGTC_1171 0368-0077 21.4 µM 0.763228848880394 0.208923349928829 no 699 0.222663463346469 1049 3239779
SGTC_2403 6032726 181.2 µM 0.762657169539972 0.20910107143892 no 700 0.222833940055586 1080 2881040
SGTC_724 3910-0327 137 µM 0.762342082352446 0.209199062593195 no 701 0.222927931899497 1113 2885483
SGTC_3151 9099821 49.47 µM 0.762054315049544 0.209288580962102 no 702 0.223013793834203 1085 17174189
SGTC_1715 st032160 10.2275 µM 0.761677712591676 0.209405768137534 no 703 0.223126190210263 1042 5289825
SGTC_2899 9053889 58.44 µM 0.761409409582224 0.209489279381379 no 704 0.223206284466326 1073 6470052
SGTC_2702 st077768 96.8 µM 0.759516649771508 0.210078970927026 no 705 0.223771779014266 1023 6484119
SGTC_3325 9138760 55.175 µM 0.758065899917834 0.210531613218257 no 706 0.22420576627148 1085 43844959
SGTC_2921 7974240 10.71 µM 0.756357174554481 0.211065478750363 no 707 0.224717538535284 1097 2979074 YDR527W RBA50
SGTC_2829 7992743 58.44 µM 0.753053094457797 0.212100036562336 no 708 0.225709004606446 1108 16462845
SGTC_2677 mitomycin C 100 µM 0.753032067010434 0.212106630057264 no 709 0.22571532229562 1104 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2716 st080858 38.6235 µM 0.750534776064617 0.212890547836999 no 710 0.226466343584693 1120 5296050
SGTC_3221 9128209 49.47 µM 0.750177736744305 0.213002763067921 no 711 0.226573832757601 1095 16460723
SGTC_2595 hexamethylquercetagetin 100 µM 0.749602749262563 0.213183550569603 no 712 0.226746997263212 1043 386331
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.745505535584189 0.214474384478152 no 713 0.227983082986861 962 4000243
SGTC_297 0986-0032 24 µM 0.745229826927825 0.214561409830687 no 714 0.228066397244159 1096 2847425
SGTC_2879 9041815 71.43 µM 0.744745778180661 0.214714245801784 no 715 0.228212709586602 1069 4942971
SGTC_1014 4130-3005 69.3 µM 0.744731466548979 0.21471876559059 no 716 0.228217036334816 1150 743608
SGTC_249 wiskostatin 11.211 µM 0.74403064669995 0.214940160725702 no 717 0.228428967333025 1138 2775510 A n-wasp and actin depolymerizer.
SGTC_1522 st012842 45.6 µM 0.743216688689715 0.215197463537466 no 718 0.228675250548238 1009 3491067 YOR116C RPO31
SGTC_3071 9117417 49.47 µM 0.742936677735448 0.215286019989104 no 719 0.228760009274996 1052 45595590 YGL055W OLE1
SGTC_2911 7942208 15.64 µM 0.742825722830195 0.215321116510948 no 720 0.228793599969774 1106 1243384
SGTC_2967 9089538 49.85 µM 0.7425230200387 0.21541688233811 no 721 0.228885254856478 1153 728216
SGTC_66 0109-0187 42.4 µM 0.740127815794411 0.21617552189965 no 722 0.2296112210564 1050 759417
SGTC_2934 9036370 36.88 µM 0.739881609519279 0.216253591075915 no 723 0.229685917141289 1142 6462800
SGTC_2749 bexarotene 57.39 µM 0.739766519238819 0.216290090477159 no 724 0.229720838844739 1112 82146 An retinoic acid receptor inhibitor.
SGTC_949 1165-0505 146 µM 0.739241456058161 0.216456652750121 no 725 0.229880195847738 1153 6244267
SGTC_1421 4029-0249 71.4 µM 0.738682230444108 0.216634133743376 no 726 0.230049989205088 1205 2894095
SGTC_1001 4048-4355 44.4 µM 0.73839045898326 0.216726766428526 no 727 0.230138605373302 1126 21824233
SGTC_14 0354-0009 295 µM 0.737339806713813 0.217060521101846 no 728 0.230457865248837 1163 1713507
SGTC_399 oxolinic acid 75 µM 0.736913246477605 0.217196108764342 no 729 0.230587553991969 1093 4628 A DNA gyrase inhibitor.
SGTC_2089 5281248 129.67 µM 0.735574257346352 0.217622041391389 no 730 0.230994916808749 1135 2737878
SGTC_1159 4092-0538 61.2 µM 0.734900222524763 0.217836634221382 no 731 0.231200131423401 1179 717301
SGTC_1816 st051957 91.6 µM 0.734222723146547 0.21805245300198 no 732 0.23140650330965 1128 674121
SGTC_547 1120-0019 610 nM 0.733471469325213 0.218291910462516 no 733 0.231635461462472 1088 3676939
SGTC_3132 9126706 49.47 µM 0.733325971936839 0.218338304351728 no 734 0.231679819004966 1141 850858
SGTC_1209 2323-2347 50.3 µM 0.732492549383664 0.218604162287132 no 735 0.231933994318955 1145 5412760
SGTC_3319 9138450 16.7555 µM 0.731782239227229 0.218830894968282 no 736 0.232150745613825 1096 2029690
SGTC_1422 4031-0024 15.5 µM 0.730425870218929 0.219264226831086 no 737 0.232564954922756 1113 782427
SGTC_2957 9076800 11.52 µM 0.730408483302166 0.219269784791384 no 738 0.232570267222583 1088 16459615
SGTC_3217 9129673 49.47 µM 0.72975596800892 0.219478428561211 no 739 0.232769681809171 1127 17248312
SGTC_968 1309-0633 340 µM 0.728664782121575 0.219827593314179 no 740 0.233103370305432 1138 3761976
SGTC_1322 1348-1070 12 µM 0.728302698311936 0.219943525659974 no 741 0.23321415547179 1123 6758089
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.726583987352299 0.220494302483341 no 742 0.23374042018705 1127 390807
SGTC_2164 5685496 200 µM 0.723754012677662 0.221402913981199 no 743 0.234608383381447 1152 759046
SGTC_3269 9137823 49.47 µM 0.723015682496653 0.22164031909816 no 744 0.23483512469083 1093 17682936
SGTC_2679 rapamycin 1 nM 0.721565724716763 0.222106966396975 no 745 0.23528075923673 1173 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2043 5101342 149 µM 0.721277343091684 0.222199844539974 no 746 0.235369446974899 1160 678451
SGTC_1970 st070122 35.8 µM 0.720984852244051 0.222294068762877 no 747 0.235459417292465 1187 102928
SGTC_1321 1326-2144 215 µM 0.717367246964645 0.223461342243023 no 748 0.236573761848875 1152 3513030
SGTC_318 1488-0629 67.2 µM 0.716604168859952 0.223708005185134 no 749 0.236809185719365 1154 3662576
SGTC_3080 9117754 49.47 µM 0.71659268525504 0.223711718411435 no 750 0.236812729609997 1201 9550191
SGTC_2448 5185112 27.17 µM 0.716110743582343 0.22386758595399 no 751 0.236961485206674 1146 5718189
SGTC_1122 capsaicin 818.572 nM 0.716006121961967 0.223901430388556 no 752 0.236993784387 1171 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2236 dapsone 200 µM 0.714358317071549 0.224434868279896 no 753 0.237502819968944 1197 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2789 5281112 71.43 µM 0.711493089375402 0.225364133276207 no 754 0.238389365842076 1168 765948
SGTC_725 1497-0963 19 µM 0.710658053537721 0.225635365693573 no 755 0.238648079494653 1193 3549977
SGTC_2066 5222451 176 µM 0.709300060195914 0.226076856906385 no 756 0.239069145541926 1201 2281147
SGTC_2351 9026858 72.31 µM 0.708781804808323 0.226245473259908 no 757 0.23922994533763 1138 1409300
SGTC_1270 0831-1170 17.3 µM 0.708007377332947 0.226497568533048 no 758 0.239470338082048 1176 6764716
SGTC_2644 guaiazulene 100 µM 0.70775894988864 0.226578471388879 no 759 0.239547481249046 1194 3515 A coloring agent.
SGTC_1840 st055363 71 µM 0.70429908358085 0.227706905308257 no 760 0.240623268456257 1139 676033
SGTC_2932 9016711 44.54 µM 0.704043916932093 0.227790252872858 no 761 0.240702712233802 1177 7117328
SGTC_1121 fusaric acid 630.51 nM 0.70362754256812 0.227926294140659 no 762 0.240832377190169 1158 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_3055 9094636 49.47 µM 0.703461183476247 0.227980661132738 no 763 0.240884194423664 1217 25236176
SGTC_1650 st011916 45.8 µM 0.701581359201918 0.228595503895766 no 764 0.241470139995382 1177 242528
SGTC_565 1418-0001 44.5 µM 0.700200005023273 0.229047902730308 no 765 0.24190120423985 1206 2862145
SGTC_2865 9030313 51.95 µM 0.699257252762463 0.229356945888012 no 766 0.242195638250381 1144 42562754
SGTC_1949 st076024 69.1 µM 0.698648135634012 0.229556744509395 no 767 0.242385976852576 1185 2921930
SGTC_1504 k297-0033 30 µM 0.698528899078432 0.229595867115142 no 768 0.242423245703808 1101 4388117
SGTC_2773 thioridazine 9.09 µM 0.697777794071574 0.229842397402028 no 769 0.2426580841634 1213 5452 An antipsychotic.
SGTC_1905 st060207 84.5 µM 0.696916756269261 0.230125192450615 no 770 0.242927445368403 1145 1948547
SGTC_368 fentichlor 4.58 µM 0.696878399666213 0.23013779463328 no 771 0.242939448349471 1160 7329 A pesticide.
SGTC_144 4161-2749 112.381 µM 0.695604828361941 0.230556449663551 no 772 0.243338170784428 1121 797501 YMR168C CEP3
SGTC_1728 st035614 33.7865 µM 0.694967940019939 0.230765970471662 no 773 0.243537696720443 1173 15945546
SGTC_209 4077-0173 175.592 µM 0.694692944107113 0.230856470316564 no 774 0.243623875418831 1152 15993494
SGTC_1310 1188-0297 994 nM 0.694639576175714 0.23087403574464 no 775 0.243640601861997 1164 1588352
SGTC_1287 0971-0001 34.6 µM 0.689884190924802 0.23244220773103 no 776 0.245133509168572 1207 4665869
SGTC_578 3460-0051 92 µM 0.689506296636981 0.232567078599081 no 777 0.245252356078497 1262 2876744
SGTC_462 ag-879 158 µM 0.688180293171265 0.233005536266542 no 778 0.245669626151915 1217 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_531 3788-1495 174 µM 0.68748150257598 0.233236783662697 no 779 0.245889676616347 1180 2896655
SGTC_2594 a-mangostin 100 µM 0.685177228382037 0.234000227810303 no 780 0.246616045778451 1229 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_731 3966-0296 387 µM 0.685094127952008 0.234027786193418 no 781 0.246642262721803 1249 660956
SGTC_1237 0330-0133 46.1 µM 0.684926990831361 0.234083218892784 no 782 0.246694996504611 1168 X1237 YHR072W ERG7
SGTC_1983 st071813 46.9 µM 0.683648409954921 0.234507513534132 no 783 0.247098603916882 1208 11838595
SGTC_415 dibenzyl ketone 100 µM 0.682328503106371 0.234945968055195 no 784 0.247515626866776 1201 7593
SGTC_440 fluspirilene 35.1 µM 0.681154953125475 0.235336185000211 no 785 0.247886724113883 1277 3396 An atypical antipsychotic.
SGTC_2772 vinpocetine 57.06 µM 0.680269247235644 0.235630927682888 no 786 0.248166996492276 1247 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_843 0310-0051 143 µM 0.678793087905993 0.236122611933032 no 787 0.248634487007545 1232 2065037
SGTC_697 0508-1955 564 µM 0.678581951666131 0.236192984093725 no 788 0.248701390870166 1216 6243113
SGTC_1062 mesoridazine 14.2 µM 0.677772986896187 0.236462720673473 no 789 0.248957820551608 1227 4078 A neuroleptic.
SGTC_1630 st005209 31.3 µM 0.677019768867147 0.236714021725094 no 790 0.249196705789567 1230 3367314
SGTC_2440 5628896 157.78 µM 0.676080546635776 0.237027586255135 no 791 0.249494753479853 1239 5522048
SGTC_1317 1273-0028 910 nM 0.674757169128741 0.237469790299703 no 792 0.249915028192591 1210 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2954 9074818 52.69 µM 0.674572721861138 0.237531458936817 no 793 0.249973634286445 1221 16648742
SGTC_1334 1486-0610 236 µM 0.674490759476595 0.237558865299876 no 794 0.249999679274407 1227 3742339
SGTC_2034 5197015 53.07 µM 0.674320734816202 0.237615723224887 no 795 0.250053712189407 1240 780676
SGTC_1591 genipin 88.4 µM 0.674165890108273 0.237667511320356 no 796 0.250102926388161 1229 442424 A DNA cross-linking agent.
SGTC_2891 9063876 19.48 µM 0.674018392066274 0.237716848068418 no 797 0.250149810378512 1192 6472478
SGTC_47 0149-0135 24.25 µM 0.673157037622818 0.238005075440417 no 798 0.250423695109954 1187 5239155
SGTC_2382 9035899 200 µM 0.670725316123132 0.238819813614239 no 799 0.251197766094482 1266 6462679
SGTC_1323 1348-1351 11.2 µM 0.668198448556952 0.239668043801143 no 800 0.252003462829582 1195 6989654
SGTC_2452 5863136 48.41 µM 0.666860749082769 0.240117753478662 no 801 0.252430542317396 1212 2184096
SGTC_1338 1486-1223 76 µM 0.666626129127072 0.24019667572882 no 802 0.252505487358075 1253 3444526
SGTC_458 nppb 133 µM 0.666255560529303 0.240321357633548 no 803 0.252623882576956 1284 4549 A chloride channel blocker.
SGTC_1048 3161-0300 24.5 µM 0.666184919442617 0.240345129609602 no 804 0.252646455446042 1251 2165101
SGTC_394 menadione 8.33 µM 0.66582415220236 0.240466554146264 no 805 0.252761752679128 1211 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2274 7947094 46.08 µM 0.665642220629688 0.240527800083237 no 806 0.252819906510837 1246 2971028
SGTC_1324 1418-0026 34.4 µM 0.665117834766488 0.240704378273628 no 807 0.252987564137467 1269 1372513
SGTC_502 l-744,832 89.3 µM 0.664555190895713 0.240893917644085 no 808 0.253167518726639 1209 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_692 k241-0027 77.8 µM 0.662479996151361 0.241593695566623 no 809 0.253831825365812 1309 3600480
SGTC_612 0302-0167 22.4 µM 0.66170192465075 0.241856353838521 no 810 0.25408113550386 1275 235821
SGTC_3189 9110682 49.47 µM 0.661387044446854 0.241962693863705 no 811 0.25418206610602 1286 17122418
SGTC_1365 1672-3266 55.4 µM 0.66099068823674 0.242096585671076 no 812 0.254309142626953 1245 6415873
SGTC_2184 6075246 200 µM 0.660859929896746 0.242140765533593 no 813 0.254351072612691 1271 2267320
SGTC_2534 helenine 20.12 µM 0.65997881676164 0.242438584817747 no 814 0.254633711653286 1265 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1803 st050068 52.4 µM 0.659903986050682 0.242463886995441 no 815 0.254657723048423 1334 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2205 7238770 200 µM 0.65891416264052 0.242798706173661 no 816 0.254975445381112 1271 279867
SGTC_411 enrofloxacin 100 µM 0.65843480893146 0.242960942980434 no 817 0.255129387115 1324 71188 A bacterial gyrase inhibitor.
SGTC_1327 1436-0082 2.18 µM 0.65577829625601 0.243861099277286 no 818 0.255983391481138 1243 15992205
SGTC_2395 5646831 180.19 µM 0.654661104003324 0.244240195509654 no 819 0.256342986664784 1288 6808628
SGTC_2278 7948257 134.34 µM 0.654417297166566 0.244322968561668 no 820 0.256421496738329 1229 1247028
SGTC_2035 5154463 94.595 µM 0.653178030918632 0.244743936304634 no 821 0.256820755800699 1255 2769623
SGTC_3238 9133470 49.47 µM 0.652640785057317 0.2449265552183 no 822 0.256993942802228 1311 3534688
SGTC_1647 st011722 22.4 µM 0.651773988233818 0.245221348569049 no 823 0.25727349214494 1262 2854783
SGTC_1245 0418-0076 17.2 µM 0.651714746167405 0.245241503467902 no 824 0.257292603983778 1274 6790114
SGTC_2 0422-0095 29 µM 0.651353764597093 0.245364333199979 no 825 0.257409074705527 1157 6790840
SGTC_1590 st077108 57.8 µM 0.651180826308496 0.245423189921126 no 826 0.257464882957237 1246 5489485
SGTC_786 4544-0069 423 µM 0.651098606309593 0.245451174815167 no 827 0.257491418062141 1297 748821 YLR208W SEC13
SGTC_1676 st018489 23.4 µM 0.651082012276631 0.245456823068116 no 828 0.257496773676063 1284 3696235
SGTC_2740 felodipine 17.08 µM 0.650915652526984 0.245513452218687 no 829 0.257550468377998 1227 3333 L-type calcium channel blocker
SGTC_1210 3013-0140 750 nM 0.650118968423176 0.245784742150068 no 830 0.257807688779193 1286 905973
SGTC_3202 9113761 49.47 µM 0.649616141047943 0.245956049662822 no 831 0.257970102102132 1317 4798415
SGTC_1058 3448-5425 97.3 µM 0.647278969551746 0.24675313742682 no 832 0.258725704972046 1212 7279705
SGTC_2863 9028737 58.44 µM 0.64672368282825 0.246942720012427 no 833 0.258905396329896 1260 6460917
SGTC_2790 5423970 71.43 µM 0.646152173129297 0.247137922714076 no 834 0.259090404856847 1307 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2940 9060638 45.86 µM 0.64589525039215 0.247225703159775 no 835 0.259173597885421 1278 4027022
SGTC_2815 7968870 71.43 µM 0.642872332220847 0.248259766902113 no 836 0.260153471829208 1273 2977326 YHR190W ERG9
SGTC_113 0099-0221 2.5 µM 0.642443161202183 0.248406762160201 no 837 0.260292741545364 1336 89219
SGTC_910 3454-3003 490 µM 0.642051588665381 0.248540920031986 no 838 0.260419843733663 1245 820824
SGTC_3045 9092950 49.47 µM 0.640927722038905 0.248926185734736 no 839 0.260784821818617 1332 44120432
SGTC_2167 5876490 200 µM 0.639841792764522 0.249298748085908 no 840 0.261137729498464 1364 686534
SGTC_1216 1165-0504 9.65 µM 0.639293381335297 0.24948701055803 no 841 0.261316046682745 1280 6304004
SGTC_652 0437-0092 114 µM 0.638145939673347 0.249881156544429 no 842 0.261689342108886 1266 3091274
SGTC_1851 st056236 18.9 µM 0.637456226520107 0.25011823182846 no 843 0.261913857022527 1306 5393171
SGTC_1071 trifluoperazine 6.31 µM 0.637422310375018 0.250129892911005 no 844 0.261924899928337 1329 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_572 0960-0087 17.7 µM 0.636017201538564 0.25061325217038 no 845 0.262382605186812 1262 6796365
SGTC_164 4100-3994 89.624 µM 0.635060858657924 0.25094251812759 no 846 0.262694361871002 1317 4615967
SGTC_3101 9120531 49.47 µM 0.634967326529424 0.250974733242477 no 847 0.262724862430122 1341 24824904
SGTC_2146 5545642 200 µM 0.633934991458211 0.251330444021094 no 848 0.263061624237846 1307 825326
SGTC_1023 4482-3888 16 µM 0.632181264257484 0.251935334680801 no 849 0.263634219274428 1317 3303168
SGTC_360 0957-0399 1.01 µM 0.628895636341025 0.253070669111535 no 850 0.264708691520776 1313 6752301 YPR165W RHO1
SGTC_428 3448-4153 16.5 µM 0.62859853424369 0.253173463982084 no 851 0.264805960085165 1251 3834874
SGTC_1388 3346-4487 254 µM 0.628072769422247 0.253355428066339 no 852 0.264978135294865 1363 3345614
SGTC_4 0960-0234 25.671 µM 0.625901923159651 0.254107472383502 no 853 0.265689636516631 1308 6821112
SGTC_1146 3579-1023 7 µM 0.624912300318337 0.25445069468847 no 854 0.266014309449893 1384 X1146
SGTC_189 3970-0742 2.116 µM 0.622861636894753 0.255162680992303 no 855 0.266687724951262 1327 2891807
SGTC_2329 6138490 200 µM 0.621680424600213 0.255573267970048 no 856 0.267076012966533 1339 720019
SGTC_1578 josamycin 24.2 µM 0.620406191881844 0.256016575284358 no 857 0.267495198455675 1234 5282165 A P450 substrate.
SGTC_595 3909-8003 73.7 µM 0.620105474931698 0.256121253598902 no 858 0.267594173948513 1344 699517
SGTC_426 0988-0037 14.6 µM 0.619331248124929 0.256390861394316 no 859 0.267849081488283 1318 5383008
SGTC_615 k087-0205 167 µM 0.618565718607255 0.256657585885392 no 860 0.268101245726341 1261 9642773
SGTC_3064 1327-0027 10 µM 0.617801721365637 0.25692392048335 no 861 0.268353024312428 1225 16000455 YPR107C YTH1
SGTC_418 lividomycin a 100 µM 0.617734686491892 0.256947296153493 no 862 0.268375121617915 1309 72394 An antibiotic.
SGTC_2754 granisetron 64.02 µM 0.616876812994504 0.257246542105675 no 863 0.268657990903673 1341 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_473 2-arachidonoylglycerol 10 µM 0.615770896154379 0.257632578404719 no 864 0.269022869205316 1274 5282280 An endocannabinoid.
SGTC_538 2922-0838 53.3 µM 0.614739107832651 0.257993010117162 no 865 0.269363514209266 1366 777039
SGTC_730 1436-0052 41.2 µM 0.614026255607243 0.258242181471767 no 866 0.269598988692293 1326 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1183 1254-0324 198 µM 0.61345891028156 0.258440581250017 no 867 0.269786471966597 1355 5799357
SGTC_90 0870-0863 4.608 µM 0.612995609810995 0.25860265525268 no 868 0.269939621292709 1298 1738164
SGTC_1162 k048-0130 20.1 µM 0.612667755823564 0.258717378504374 no 869 0.270048023502819 1308 6797406
SGTC_1057 3448-5381 134 µM 0.612103256225097 0.258914970921189 no 870 0.270234721650061 1349 5497911
SGTC_1940 st075990 51.1 µM 0.611933678906545 0.258974343501786 no 871 0.270290818919778 1412 1084979
SGTC_816 0325-0417 81.3 µM 0.611778204472825 0.259028784553495 no 872 0.270342255979771 1296 68101
SGTC_183 3914-0051 30.55 µM 0.611775138989102 0.259029858025215 no 873 0.27034327021159 1330 1596232
SGTC_3119 9125183 49.47 µM 0.610938139366397 0.259323044772806 no 874 0.270620267190066 1198 22695334
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.609900091725866 0.259686893273517 no 875 0.270963995878389 1316 688798
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.608477909468474 0.260185813158004 no 876 0.27143527642944 1322 521171
SGTC_2203 7227154 166.4 µM 0.606227746628899 0.260976207294784 no 877 0.272181765122682 1315 896304
SGTC_1398 3558-0053 112 µM 0.605619621905154 0.261190029437531 no 878 0.27238368474323 1273 4532369
SGTC_2741 miltefosine 3.04 µM 0.605250233491299 0.261319953674604 no 879 0.272506371503159 1281 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1926 methyl fluorone black 53.6 µM 0.60487653434683 0.261451427890174 no 880 0.27263051792136 1197 72721 Reacts with homocysteine.
SGTC_1176 0848-0131 83.3 µM 0.6034484453321 0.261954168533796 no 881 0.273105201167792 1384 6769040
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.603035759364552 0.262099541657728 no 882 0.273242450316772 1399 94937 An inhibitor of serotonin biosynthesis.
SGTC_2027 5150920 200 µM 0.602655104197826 0.262233668231448 no 883 0.273369077100192 1323 786715
SGTC_3323 9138564 53.9225 µM 0.600866701366164 0.262864295120984 no 884 0.273964386647259 1349 43912313 YNL103W MET4
SGTC_3075 9116269 49.47 µM 0.600441276221943 0.263014422697669 no 885 0.274106093125423 1367 17015205 YNL244C SUI1
SGTC_1254 0550-0035 264 µM 0.600041869449475 0.263155408568622 no 886 0.274239165994649 1379 15121435
SGTC_2108 5365811 200 µM 0.59834192156566 0.263755901664668 no 887 0.274805904948461 1398 780283
SGTC_2299 7976368 114.88 µM 0.59830461594223 0.263769087411817 no 888 0.274818348595035 1403 2979718
SGTC_2505 galangin 7.89 µM 0.59778071752347 0.26395429585705 no 889 0.27499312924379 1299 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3205 9113483 49.47 µM 0.597290629931061 0.264127611491087 no 890 0.275156679636447 1384 17018033
SGTC_1842 st055362 61.2 µM 0.596517553778863 0.264401121610363 no 891 0.27541476535242 1377 676032
SGTC_2447 5741742 33.78 µM 0.595620101398193 0.264718816079464 no 892 0.275714522453236 1416 1776504
SGTC_3190 9110366 49.47 µM 0.594747476678267 0.265027907685998 no 893 0.276006140580863 1303 17123768
SGTC_328 k915-0120 63.5 µM 0.594446562953845 0.265134536561633 no 894 0.276106736556193 1369 6624543
SGTC_369 0957-0393 4.5 µM 0.594378486230248 0.265158662592516 no 895 0.276129497218292 1316 6997992
SGTC_854 0422-0053 192 µM 0.5939349609198 0.265315872906272 no 896 0.2762778072995 1334 3596728
SGTC_2905 7799065 20.05 µM 0.5931460310435 0.265595630905687 no 897 0.276541713497665 1326 1296806
SGTC_2117 5521686 200 µM 0.592925135095588 0.26567398838014 no 898 0.276615627894998 1321 803312
SGTC_1107 amlodipine 47 µM 0.591914650303783 0.266032582720588 no 899 0.2769538714663 1258 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1843 st055809 45.5 µM 0.591513873675006 0.266174875620621 no 900 0.277088081074106 1345 16413835
SGTC_67 0335-0847 266 µM 0.591241815077713 0.266271490048428 no 901 0.277179204513272 1560 4552207 YOR254C SEC63
SGTC_1656 st012921 11 µM 0.58950925320323 0.266887179810783 no 902 0.277759853368453 1352 6732821
SGTC_687 k029-0044 34.9 µM 0.588569724323098 0.267221354858871 no 903 0.278074974226441 1402 5829338
SGTC_795 0685-0265 78 µM 0.587904561387185 0.267458070041234 no 904 0.278298177302865 1378 302754
SGTC_2519 cryptotanshinone 88.04 µM 0.585285275891569 0.268391236506875 no 905 0.279177956820534 1360 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2877 9040724 71.43 µM 0.584197685840778 0.268779190077074 no 906 0.279543659151639 1417 6463895
SGTC_1906 st060206 94.7 µM 0.583765042689011 0.268933596221139 no 907 0.279689200118055 1346 5133468
SGTC_1567 st069303 68.4 µM 0.58373203749695 0.268945377282025 no 908 0.27970030455965 1386 5581319
SGTC_2840 9008771 71.43 µM 0.583329619424872 0.269089039511158 no 909 0.279835713430874 1359 2992978
SGTC_376 3970-0862 59.1 µM 0.583171189044917 0.269145609317269 no 910 0.27988903208229 1385 3135186
SGTC_3209 9113616 49.47 µM 0.582378124828694 0.269428873764898 no 911 0.280156006408245 1402 16649353
SGTC_866 0495-0101 262 µM 0.581391656690584 0.26978142611817 no 912 0.280488259649814 1314 635694
SGTC_1363 1636-0063 10.4 µM 0.581187389576449 0.26985445769174 no 913 0.280557082872784 1386 6072185
SGTC_2238 6671620 73.2395 µM 0.579076691142094 0.270609674257011 no 914 0.281268713457273 1326 729941
SGTC_1215 3852-0577 11.2 µM 0.579053322838812 0.270618041436655 no 915 0.281276597051098 1470 2884876
SGTC_2461 5755302 26.15 µM 0.578693265612354 0.270746978702467 no 916 0.281398080411141 1452 2788904
SGTC_2104 5389443 200 µM 0.578285300635881 0.270893108890727 no 917 0.281535758444214 1458 2244536
SGTC_2009 4012297 12.05 µM 0.577495022642846 0.271176292837557 no 918 0.28180255001065 1366 45595307
SGTC_3004 9076122 71.4286 µM 0.576852069444138 0.271406794053726 no 919 0.282019695750416 1403 44782551
SGTC_1376 2910-0861 41.3 µM 0.576263087676747 0.271618031938396 no 920 0.282218684316146 1415 1112859
SGTC_1348 1493-0373 93.8 µM 0.575664939051388 0.271832641258639 no 921 0.282420839056389 1401 3010129
SGTC_810 3825-7150 143 µM 0.575306536280732 0.271961272744934 no 922 0.282542000870364 1408 22330411 YGL099W LSG1
SGTC_708 3448-5400 146 µM 0.574576054843452 0.272223537723497 no 923 0.282789025124115 1362 3462195
SGTC_924 2046-0044 21.3 µM 0.574129458847836 0.272383941112244 no 924 0.282940099956017 1347 3623589
SGTC_1462 k081-0014 26.5 µM 0.572614760819117 0.272928322923226 no 925 0.283452781556963 1212 3270634
SGTC_3136 9095672 49.47 µM 0.57230978735948 0.273037995464849 no 926 0.2835560601054 1257 17217380
SGTC_2248 tofa 1.1 µM 0.57042518855093 0.273716206669352 no 927 0.284194674746917 1388 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2020 4017018 200 µM 0.569428980349314 0.274075048810496 no 928 0.284532527200254 1372 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_507 nimesulide 162 µM 0.569374757914706 0.274094586832072 no 929 0.284550921613083 1431 4495 A COX2 inhibitor.
SGTC_2458 5808907 16.39 µM 0.56507250471159 0.275647011565282 no 930 0.286012224616689 1410 2731747
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.564906438888451 0.275707021286251 no 931 0.286068701937109 1371 16623 A steroid.
SGTC_2292 7671323 168.05 µM 0.564541082480123 0.275839069464835 no 932 0.286192974636355 1375 937504
SGTC_2405 ticlatone 3.52 µM 0.564295597077369 0.275927810965399 no 933 0.286276488689611 1264 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_488 nitrendipine 139 µM 0.563845195577538 0.276090664865229 no 934 0.286429745216212 1431 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1442 4112-3290 3 µM 0.562779228968194 0.276476279585317 no 935 0.286792612947462 1370 704353
SGTC_1195 1502-0147 41.1 µM 0.562079133203348 0.276729683681884 no 936 0.28703105237216 1376 817940
SGTC_2576 guaiol 23.12 µM 0.560041579996666 0.277467835856017 no 937 0.287725538331373 1419 227829
SGTC_2849 9019321 12.99 µM 0.559933507860592 0.277507014421848 no 938 0.287762396135331 1391 16489627
SGTC_2430 5571206 200 µM 0.559803836454194 0.27755402677402 no 939 0.287806623274489 1433 1731771
SGTC_891 0929-0073 133 µM 0.558389819870964 0.278066930765764 no 940 0.288289111420281 1457 5603632
SGTC_1411 3909-8223 150 µM 0.557902949746325 0.278243639345719 no 941 0.288455328587489 1440 X1411
SGTC_2176 5809774 33.9695 µM 0.557042483451312 0.278556077769522 no 942 0.288749201668376 1403 2870539
SGTC_851 0394-0702 453 µM 0.556609254083406 0.278713449571453 no 943 0.288897214836426 1415 762646
SGTC_3321 9137793 26.8275 µM 0.554203690867025 0.27958806382154 no 944 0.289719726337782 1390 4904192
SGTC_2976 9009005 19.48 µM 0.553038062934444 0.280012341304562 no 945 0.290118673350786 1521 2993148
SGTC_2763 lisinopril 49.32 µM 0.55279263531154 0.280101714387563 no 946 0.290202706038459 1382 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_3278 9139605 49.47 µM 0.552451160248862 0.280226086380191 no 947 0.290319643659124 1453 7958859
SGTC_802 4112-3352 742 µM 0.552402046106342 0.28024397692573 no 948 0.290336464538237 1500 704594
SGTC_2820 7989630 71.43 µM 0.549322161276682 0.281366973893872 no 949 0.291392190732755 1349 2984098
SGTC_223 busulfan 5 mM 0.546711900039165 0.282320432500976 no 950 0.29228833868223 1439 2478 A DNA alkylator.
SGTC_5 0352-0601 109.883 µM 0.546249428038235 0.282489523120816 no 951 0.292447246920695 1372 762456
SGTC_252 miconazole 1.30953 nM 0.545394442439466 0.282802254101053 no 952 0.292741130963752 1392 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1233 0325-0408 14.2 µM 0.545369315527735 0.282811447371732 no 953 0.29274976990662 1476 12874
SGTC_3109 9122853 49.47 µM 0.543428076438007 0.283522128877937 no 954 0.293417549480885 1500 1234709
SGTC_3031 9088762 49.47 µM 0.541776639619601 0.284127387607186 no 955 0.293986192988941 1362 205253
SGTC_1608 st001473 40.5 µM 0.5415934585205 0.284194562326694 no 956 0.294049299591196 1379 7292267
SGTC_264 promethazine 12.5 mM 0.539323783700172 0.285027508780044 no 957 0.294831730328242 1427 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_641 4092-0595 30 µM 0.538570273536619 0.285304296123125 no 958 0.29509170182746 1450 786260
SGTC_2797 7859098 81.82 µM 0.536663166533063 0.286005406456193 no 959 0.295750151575292 1428 972681
SGTC_3235 9132602 49.47 µM 0.536071326148154 0.28622315128276 no 960 0.295954628171174 1462 4912240
SGTC_2389 9091542 195.52 µM 0.535656401892998 0.286375853577202 no 961 0.296098020209686 1413 3626624 YOL127W RPL25
SGTC_2622 2-methoxyxanthone 59.94 µM 0.535655478180706 0.286376193569098 no 962 0.296098339467341 1533 71034 A hepatoprotective.
SGTC_1677 st019204 53.9 µM 0.534842446039172 0.286675521562153 no 963 0.296379404581274 1381 3945625
SGTC_2959 9079155 11 µM 0.534240122118006 0.28689737029862 no 964 0.296587706724935 1426 16189457
SGTC_2928 9011484 9.79 µM 0.534167348634722 0.286924179830391 no 965 0.296612878574753 1432 2994751
SGTC_799 1310-0557 151 µM 0.533740484235337 0.287081459282927 no 966 0.296760547749486 1447 5354492
SGTC_3283 9109332 35.8195 µM 0.532503553560224 0.287537440452358 no 967 0.297188640639902 1384 17027281
SGTC_1671 st016596 74.5 µM 0.529383948406724 0.288688967589507 no 968 0.298269565452529 1434 2829167
SGTC_1127 asiatic acid 681.4 nM 0.527425196902915 0.289413101708878 no 969 0.298949174849408 1416 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2157 5649910 96.377 µM 0.527286716611072 0.289464328998713 no 970 0.298997248649497 1399 2858091
SGTC_3152 9099253 49.47 µM 0.526315159144634 0.289823851869382 no 971 0.299334626069264 1452 25236131
SGTC_1736 st036774 51 µM 0.526036983053972 0.289926828929303 no 972 0.299431255674663 1584 1272247
SGTC_2742 clothiapine 36.27 µM 0.525976925370586 0.289949063730528 no 973 0.299452119677024 1485 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_741 4582-0002 126 µM 0.524297098680419 0.290571299744412 no 974 0.300035957268524 1416 2912688
SGTC_659 k018-0002 107 µM 0.524061821070564 0.290658500381489 no 975 0.300117771036942 1482 6797879 YHR007C ERG11
SGTC_2948 9070189 9.45 µM 0.522253668684429 0.291329061732374 no 976 0.300746861569078 1487 6473636 YDL196W YDL196W
SGTC_760 0568-0725 82.9 µM 0.521319696476572 0.291675712011742 no 977 0.301072041105978 1517 3916171
SGTC_2886 9058944 51.95 µM 0.521137459383055 0.291743372986614 no 978 0.301135508760688 1380 4949929
SGTC_525 k781-2675 26.7 µM 0.520818308577478 0.291861884892342 no 979 0.301246673831574 1463 3651118 YDL195W SEC31
SGTC_2373 9071805 200 µM 0.520249704244066 0.292073083204412 no 980 0.301444773137777 1556 10149009
SGTC_10 0279-0212 42.575 µM 0.519960355620172 0.292180584083664 no 981 0.301545603458913 1436 39851 YBR002C RER2
SGTC_3339 9145883 14.936 µM 0.518821157649612 0.292604005920482 no 982 0.301942731125567 1463 2030670
SGTC_3084 9116877 49.47 µM 0.513930281214162 0.294425098414329 no 983 0.303650367729617 1416 27241325
SGTC_868 0527-0199 213 µM 0.513386722571992 0.294627812300092 no 984 0.30384041570218 1482 2849450
SGTC_3150 9097574 49.47 µM 0.512072387978313 0.295118243997355 no 985 0.304300174233363 1554 17217476
SGTC_74 000s-0487 160.283 µM 0.51173519184368 0.295244126160412 no 986 0.304418176458475 1372 677548
SGTC_2929 9013348 24.6 µM 0.510836277499604 0.295579829843424 no 987 0.304732852176353 1464 2995952
SGTC_192 3455-0609 60.9 µM 0.510407710583689 0.29573994187666 no 988 0.304882928042379 1480 3769639
SGTC_888 0916-0002 6.97 µM 0.509070191062316 0.296239893480916 no 989 0.305351512607249 1513 2802138 YIL048W NEO1
SGTC_421 streptovitacin 30 mM 0.508282752393708 0.2965344114629 no 990 0.305627531980926 1484 91467 include heat shock
SGTC_150 3970-0969 77.2 µM 0.505646971601327 0.297521221484009 no 991 0.306552250418207 1513 6615640
SGTC_353 1988-1175 58.3 µM 0.503379096494791 0.298371489337954 no 992 0.307348882706013 1404 2788357
SGTC_3305 9127027 53.8275 µM 0.503159673179227 0.298453813800997 no 993 0.30742600745598 1476 41905295
SGTC_84 0443-0269 128.823 µM 0.50286288936387 0.298565179248481 no 994 0.307530337071667 1448 6150058
SGTC_973 1325-0077 65.9 µM 0.502798282175307 0.298589425017655 no 995 0.307553050762211 1588 2835149
SGTC_133 0724-0033 378.92 µM 0.502506701509666 0.298698860473806 no 996 0.307655569787498 1383 280309
SGTC_1257 0669-0121 16 µM 0.501129925238651 0.299215835450768 no 997 0.308139843664259 1578 4307855
SGTC_2084 5306078 60.6385 µM 0.499847455672791 0.299697763488032 no 998 0.308591246342355 1501 679340
SGTC_1471 k673-0312 37 µM 0.499451659660666 0.299846567183097 no 999 0.308730616803973 1470 24099884
SGTC_886 0866-0150 153 µM 0.498472215029437 0.300214943467066 no 1000 0.309075624125118 1591 271463
SGTC_1766 st045414 44.774 µM 0.497627502390399 0.300532810293103 no 1001 0.309373307705305 1492 253960
SGTC_2127 5253358 187.912 µM 0.496448200814727 0.300976837532206 no 1002 0.309789112442117 1429 20612
SGTC_263 alizarin 107.927 µM 0.49584030683894 0.301205835489878 no 1003 0.310003542235179 1520 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_1330 1469-0054 61.8 µM 0.495168138419217 0.301459137417024 no 1004 0.310240719584101 1607 7102664
SGTC_804 1595-0054 20.9 µM 0.493158994698117 0.302216839942316 no 1005 0.310950124466889 1473 761523 Stimulates phospholipase C.
SGTC_2369 9071472 200 µM 0.492713322456365 0.302385030772498 no 1006 0.311107581439349 1544 17296037
SGTC_1502 4534-4282 27.7 µM 0.492290389825421 0.302544678784776 no 1007 0.311257036436252 1495 3278949
SGTC_3195 9113082 49.47 µM 0.491168996891596 0.302968163383209 no 1008 0.311653462386003 1539 17018038
SGTC_2541 muurolladie-3-one 83.07 µM 0.490692969095544 0.303148011444868 no 1009 0.311821810020127 1520 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2890 9046729 58.44 µM 0.489629516760022 0.303549966747308 no 1010 0.31219804286654 1422 903329
SGTC_2257 7960413 200 µM 0.489579058964365 0.303569044298797 no 1011 0.312215898919366 1576 2974689 YIL048W NEO1
SGTC_2338 7999974 200 µM 0.487396234773445 0.304394858697275 no 1012 0.312988780654968 1580 315925
SGTC_855 0428-0020 25 µM 0.487390065856175 0.304397193962228 no 1013 0.312990966076574 1489 6812414
SGTC_3207 9114163 49.47 µM 0.485827723269547 0.30498888071597 no 1014 0.313544658263473 1671 849233
SGTC_40 0327-0103 19.753 µM 0.48475960323759 0.305393690412614 no 1015 0.313923440650448 1466 409036
SGTC_3354 9151612 71.43 µM 0.483670446338249 0.305806718111953 no 1016 0.314309885251537 1584 27261949
SGTC_684 1140-0066 328 µM 0.482718186197107 0.306168034643697 no 1017 0.314647924266992 1481 6813534
SGTC_3094 9117742 49.47 µM 0.482578027104185 0.306221231209894 no 1018 0.314697691909509 1442 17149698
SGTC_145 3737-0113 38.366 µM 0.482077502005635 0.306411235933371 no 1019 0.314875445659775 1540 6849351
SGTC_1234 0326-0494 15.5 µM 0.481587791994955 0.306597185521964 no 1020 0.315049400114455 1587 1547813
SGTC_2898 9056270 58.44 µM 0.481270869076615 0.306717552033757 no 1021 0.315161999127208 1495 19154699
SGTC_1337 1486-1011 40.3 µM 0.481208393738883 0.30674128246699 no 1022 0.315184197912212 1490 X1337
SGTC_2634 4'-methoxyflavone 100 µM 0.479810479679918 0.307272473377089 no 1023 0.315681080219314 1512 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2309 7664088 163.95 µM 0.477666798991386 0.30808783256402 no 1024 0.316443689300331 1582 704922
SGTC_104 0074-0074 590.992 µM 0.475878511472557 0.308768741893408 no 1025 0.317080465990335 1462 3943124
SGTC_3091 9116372 49.47 µM 0.475763900012222 0.30881240387312 no 1026 0.317121295551551 1512 17169793
SGTC_2808 7946468 45.46 µM 0.475032549790576 0.309091080104558 no 1027 0.317381886559216 1560 2970879
SGTC_1943 st076331 65.2 µM 0.472343227085152 0.310116773084444 no 1028 0.318340910255319 1548 24208415
SGTC_1000 4048-0884 8.67 µM 0.469461912899579 0.311217332151555 no 1029 0.319369751420874 1563 13040088
SGTC_2170 morpholine 200 µM 0.469032578485344 0.311381467448354 no 1030 0.319523174773 1599 121171 Reacts with secondary amines.
SGTC_2603 homopterocarpin 100 µM 0.468514238957601 0.311579679522725 no 1031 0.319708445415821 1530 101795 A weak amylase inhibitor.
SGTC_3179 9107801 49.47 µM 0.467263754895497 0.312058087030124 no 1032 0.320155592399987 1494 4818259
SGTC_468 gf-109203x 121 µM 0.465342958590628 0.312793558747359 no 1033 0.320842937886505 1562 2396 A protein kinase C inhibitor.
SGTC_327 1273-0057 3.96 µM 0.46491783068814 0.312956440870363 no 1034 0.320995150511126 1509 3108138
SGTC_2253 7938677 135.83 µM 0.464445306974485 0.313137524920549 no 1035 0.321164368018382 1645 2301972
SGTC_2032 5185112 25.99 µM 0.463521454718888 0.31349170064003 no 1036 0.321495320006004 1540 5718189
SGTC_3340 9146634 11.102 µM 0.460386703655233 0.314694745671056 no 1037 0.322619338409425 1532 4907387
SGTC_2650 prasterone 100 µM 0.460139973998599 0.314789518589064 no 1038 0.322707876558659 1532 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_2864 9034755 47.6 µM 0.460134378880931 0.314791667907247 no 1039 0.322709884465343 1516 4930451
SGTC_1913 st060213 96.1 µM 0.459575352422376 0.315006444916814 no 1040 0.322910527024388 1651 688959
SGTC_1714 st033236 13.627 µM 0.458776817026561 0.315313349358964 no 1041 0.323197222158873 1645 2916566
SGTC_2888 9058547 12.99 µM 0.458205527281021 0.315532993775323 no 1042 0.323402394619088 1492 16476514
SGTC_1264 0783-0040 158 µM 0.458192913848764 0.31553784401172 no 1043 0.323406925201514 1463 2855798
SGTC_342 k048-0088 23.3 µM 0.45789858346506 0.315651031738615 no 1044 0.323512652317849 1498 6820570
SGTC_3072 9116419 49.47 µM 0.454689361074189 0.316886291107282 no 1045 0.324666367922274 1489 17170162
SGTC_31 0508-1974 57.237 µM 0.454347400818266 0.317018035511908 no 1046 0.324789402139213 1590 6810525
SGTC_2485 5633444 17.78 µM 0.454154474693403 0.317092372917919 no 1047 0.324858823655418 1492 5724239
SGTC_1735 st034310 56.75 µM 0.453722430358303 0.31725887302454 no 1048 0.325014310264363 1638 871153
SGTC_2100 5377183 190 µM 0.453396223056825 0.317384610445925 no 1049 0.325131727828463 1652 2844202
SGTC_466 geldanamycin 89.2 µM 0.452649614772731 0.317672471783974 no 1050 0.325400533102192 1566 5288382 HSP90 inhibitor.
SGTC_2216 7189485 200 µM 0.451947890962912 0.31794312804382 no 1051 0.325653261216242 1623 731273
SGTC_853 0419-0306 21 µM 0.451718108686899 0.318031776671209 no 1052 0.325736035478414 1488 762713
SGTC_1556 plumbagin 1.48 µM 0.446797491374816 0.319932616862252 no 1053 0.327510641375895 1527 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1654 st012436 41.8 µM 0.44589524229732 0.320281672179832 no 1054 0.32783645956417 1581 4323132
SGTC_542 3381-0244 89.3 µM 0.444125640583767 0.320966744114664 no 1055 0.328475874755657 1671 1112843
SGTC_1767 st044992 70.3 µM 0.443886215955521 0.321059480281173 no 1056 0.328562425380013 1505 9600693
SGTC_965 1291-5240 308 µM 0.442857120768207 0.321458206004456 no 1057 0.328934542055703 1652 2834598
SGTC_1871 st057448 67.3 µM 0.441887399431935 0.321834115532682 no 1058 0.32928534462166 1650 691747
SGTC_1622 st003707 19.4 µM 0.440212668533049 0.32248374929657 no 1059 0.329891542570146 1604 10140899
SGTC_2463 5473429 200 µM 0.438624361997153 0.3231003599799 no 1060 0.330466870805521 1565 5399405
SGTC_2231 micatex 6.853 µM 0.438415957435372 0.323181302713404 no 1061 0.330542390441322 1596 20737 An antifungal of unknown mechanism.
SGTC_372 0155-0182 15.9 µM 0.438306498563521 0.323223819053446 no 1062 0.33058205785603 1634 771486
SGTC_979 1426-2828 121 µM 0.438108051614984 0.323300906294278 no 1063 0.330653979011791 1653 747872
SGTC_2843 9000894 45.46 µM 0.43734338516059 0.323598013913332 no 1064 0.330931167926489 1513 2242070
SGTC_2986 9022445 71.43 µM 0.43703313170443 0.323718593549259 no 1065 0.331043660166416 1681 6459286
SGTC_649 1123-0311 367 µM 0.43628422903941 0.324009729911354 no 1066 0.331315261435458 1593 693629 YIL048W NEO1
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.436010571605828 0.324116141275363 no 1067 0.33141452973379 1620 140250 A respiratory chain inhibitor.
SGTC_2483 5729050 27.16 µM 0.435647944186434 0.32425717064936 no 1068 0.331546089836976 1708 2865180
SGTC_1515 3460-0031 42.1 µM 0.435557013476493 0.324292538453029 no 1069 0.331579082476571 1542 2876596
SGTC_2983 9022671 12.99 µM 0.435538731936549 0.324299649310535 no 1070 0.331585715775766 1709 6405161
SGTC_1274 0865-0114 173 µM 0.435353186968477 0.3243718232142 no 1071 0.331653042156163 1594 870624
SGTC_2985 9022375 71.43 µM 0.432521643801017 0.325474063706192 no 1072 0.332681162480591 1575 4939335
SGTC_2902 5787006 60.46 µM 0.430578694456813 0.326231284245121 no 1073 0.333387367748285 1548 591003
SGTC_501 nsc-95397 161 µM 0.430082498921529 0.326424780271417 no 1074 0.333567815147933 1649 262093
SGTC_2880 9042983 58.44 µM 0.429838683313535 0.326519875538097 no 1075 0.333656495703048 1583 6464714
SGTC_1879 gemcitabine 100 µM 0.429270706791158 0.326741446823416 no 1076 0.333863116026288 1599 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2101 5377231 179.231 µM 0.428496181435343 0.327043692621007 no 1077 0.334144956535199 1670 2844213
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.428146999850778 0.327179992123265 no 1078 0.334272050139491 1601 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1749 st037932 54.2 µM 0.426945573639684 0.327649132699149 no 1079 0.334709485148223 1565 594497
SGTC_2737 bleomycin 30.5 nM 0.425448595928733 0.328234062979707 no 1080 0.335254843392688 1598 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2050 5263056 171 µM 0.424959690323786 0.328425189706302 no 1081 0.335433030045269 1701 763468 YGL055W OLE1
SGTC_2570 licareol 100 µM 0.42459754383157 0.328566791744545 no 1082 0.335565041913601 1554 443158
SGTC_1701 st028638 40.4 µM 0.42273553655008 0.329295239172861 no 1083 0.336244112479267 1680 3490878
SGTC_1967 st070177 51.4 µM 0.422326104747541 0.329455502597996 no 1084 0.336393503275348 1639 5729214
SGTC_923 1900-2434 73.3 µM 0.42139193729799 0.329821279962508 no 1085 0.336734452861252 1541 5910570
SGTC_3225 9130819 49.47 µM 0.42033175269806 0.330236597117581 no 1086 0.337121558415096 1628 4547121
SGTC_884 0851-0618 334 µM 0.420303440355676 0.330247691077084 no 1087 0.337131898477063 1688 9642473
SGTC_2165 5727197 32.143 µM 0.420023759555118 0.330357289725198 no 1088 0.337234048412949 1663 1361712
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.419118827630203 0.330712005516045 no 1089 0.33756464574762 1701 165506
SGTC_1491 4138-0063 26.5 µM 0.418797197749942 0.33083811484973 no 1090 0.337682176497364 1657 23883227
SGTC_2826 7992541 19.48 µM 0.418634017287158 0.330902104367849 no 1091 0.337741812341675 1643 2985066
SGTC_3265 9137266 49.47 µM 0.417885948115439 0.3311955151158 no 1092 0.338015253427476 1734 17224265
SGTC_1350 1495-0454 146 µM 0.416871914591045 0.33159340898288 no 1093 0.338386048702288 1671 1069057
SGTC_298 1391-0729 10 µM 0.416710231773156 0.3316568688492 no 1094 0.338445184743226 1591 3237558
SGTC_985 1493-0307 8.71 µM 0.416660157700882 0.331676523704463 no 1095 0.338463500313736 1715 3278274
SGTC_2103 5378138 10 µM 0.416658046349715 0.331677352452946 no 1096 0.338464272590083 1652 244142
SGTC_379 3970-0972 5.9 µM 0.416234300848353 0.331843697892939 no 1097 0.338619281220463 1628 2898042 YBL034C STU1
SGTC_3081 9117243 49.47 µM 0.415869771470349 0.331986823996084 no 1098 0.338752650118762 1723 45595589
SGTC_204 PMA1.184 62.41 µM 0.415089456724807 0.332293283369074 no 1099 0.339038208686546 1603 2252213 YGL008C PMA1
SGTC_603 3794-0023 45.9 µM 0.414567850394235 0.332498200641565 no 1100 0.339229143713827 1704 3802260
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.412283640710505 0.333396159960075 no 1101 0.340065768959492 1662 676296 Flavone; oxidizing agent.
SGTC_378 3970-0959 8.33 µM 0.409448302270455 0.334512105778681 no 1102 0.341105349259869 1638 6615653
SGTC_3250 9135583 49.47 µM 0.409386214882172 0.334536558836384 no 1103 0.34112812721304 1695 7699353
SGTC_568 1193-0097 7.48 µM 0.408990508425382 0.334692423930135 no 1104 0.341273313342305 1606 3646150
SGTC_2699 st077704 54.6 µM 0.407885526297532 0.335127816892221 no 1105 0.341678859646467 1616 645852
SGTC_1939 st074455 53.6 µM 0.407604141575168 0.335238725540129 no 1106 0.341782161610714 1750 1644229
SGTC_1203 3992-3522 103 µM 0.406274657568554 0.33576293984641 no 1107 0.342270401933261 1841 5322312
SGTC_515 4092-1064 102 µM 0.406051698931105 0.335850883564001 no 1108 0.342352307214548 1747 717353
SGTC_2572 astragaloside iv 100 µM 0.405963786297241 0.335885562260104 no 1109 0.342384604521392 1636 45006101 An anti-inflammatory agent.
SGTC_81 0411-0046 9.971 µM 0.40449177868906 0.336466429117733 no 1110 0.342925561136292 1572 12925265
SGTC_2680 butyl paraben 22.24 µM 0.404457739884898 0.336479865747075 no 1111 0.342938074068974 1632 7184 An antifungal and steroid mimetic.
SGTC_16 erodoxin 22.806 µM 0.403611805111333 0.336813860854123 no 1112 0.343249101667655 1626 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_764 1951-2361 146 µM 0.403362095109629 0.336912476904667 no 1113 0.34334093367094 1559 5438930
SGTC_2719 novobiocin 32.65 µM 0.403080068933833 0.337023868815541 no 1114 0.34344466121907 1711 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_470 aa-861 153 µM 0.400989188662627 0.337850149262102 no 1115 0.344214041862031 1592 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2003 4023581 200 µM 0.399971576393767 0.338252575562589 no 1116 0.344588726014635 1626 16641307
SGTC_3100 9120536 49.47 µM 0.398422171966673 0.338865659976517 no 1117 0.345159508502998 1696 16421196
SGTC_2081 5214970 32.255 µM 0.398230382167047 0.338941579091073 no 1118 0.345230186162486 1717 2063512
SGTC_315 k915-0449 187 µM 0.395889863585831 0.339868588903436 no 1119 0.346093139572582 1691 20970215 YNL149C PGA2
SGTC_1985 st071382 65.5 µM 0.395608720292655 0.339980006711806 no 1120 0.346196851506778 1637 6123237
SGTC_1670 st016595 4.04 µM 0.394769677074127 0.34031260476526 no 1121 0.346506437657455 1646 597879
SGTC_1804 st050076 49.1 µM 0.39116359263341 0.341743474245395 no 1122 0.347838158752139 1672 3895976
SGTC_184 1494-0393 24.714 µM 0.390922603865641 0.341839178311603 no 1123 0.347927222683169 1598 3090647
SGTC_511 blebbistatin 171 µM 0.390116027762519 0.342159568454737 no 1124 0.348225375758771 1740 3476986 A myosin inhibitor.
SGTC_2442 5158906 48.48 µM 0.38985023227203 0.342265173303785 no 1125 0.348323648356219 1729 1893835
SGTC_1917 st066507 28.5 µM 0.389458658905677 0.342420774210196 no 1126 0.348468443372855 1622 3156428
SGTC_1606 st000094 49.2 µM 0.389277252800141 0.34249286927059 no 1127 0.348535530753478 1798 1242210
SGTC_763 3453-1109 128 µM 0.38687311601096 0.34344887100416 no 1128 0.349425072361213 1762 1560353
SGTC_1305 1181-0477 144 µM 0.385755457162356 0.343893648244472 no 1129 0.349838893364571 1747 6252086
SGTC_442 cape 100 µM 0.384784422560074 0.344280251206607 no 1130 0.350198570604457 1757 5281787
SGTC_2851 9015922 71.43 µM 0.38425469358219 0.344491223557562 no 1131 0.350394842186898 1737 2996893
SGTC_299 1273-0059 1.44 µM 0.38393793507154 0.344617400411759 no 1132 0.350512224490652 1664 2848077
SGTC_1405 3909-7894 12 µM 0.383929343486223 0.344620823004918 no 1133 0.350515408503235 1733 7104060
SGTC_2484 5809818 12.04 µM 0.383393864444456 0.34483416459485 no 1134 0.350713875950859 1670 2870548
SGTC_676 falcarinol 140 µM 0.38277681104749 0.345080067627852 no 1135 0.350942628266772 1776 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_2788 5282734 71.43 µM 0.38275955976931 0.34508694340574 no 1136 0.350949024389372 1771 743706
SGTC_290 2043-6722 48.1 µM 0.381148097208835 0.345729443304568 no 1137 0.351546679876287 1666 773758 YLR208W SEC13
SGTC_1446 4239-0190 62 µM 0.380763990373958 0.345882654712486 no 1138 0.351689190769105 1636 1340085
SGTC_1891 st059073 26.2 µM 0.379775825111808 0.346276927108176 no 1139 0.352055914498549 1791 688754
SGTC_1243 0416-0003 5.65 µM 0.379091629899377 0.346550014829967 no 1140 0.352309910810874 1641 2141977
SGTC_2974 9094440 9.66 µM 0.378635698856115 0.346732038142639 no 1141 0.352479204362243 1754 25236134
SGTC_1959 st077091 55.8 µM 0.377201309758369 0.347304926086972 no 1142 0.353012003508608 1643 821356 YKL052C ASK1
SGTC_128 0906-2981 13.371 µM 0.376406635755257 0.347622465315778 no 1143 0.35330730675991 1737 6740226
SGTC_331 k048-0133 24.5 µM 0.376117565830294 0.347737999646926 no 1144 0.353414747935426 1629 6813582
SGTC_2812 7970281 58.44 µM 0.3758590728615 0.347841325077588 no 1145 0.35351083419736 1763 2233435
SGTC_251 melphalan 456.522 µM 0.375572561850419 0.347955863152152 no 1146 0.353617346153669 1755 460612 A DNA alkylator.
SGTC_913 3487-1245 167 µM 0.375325621928118 0.348054593085079 no 1147 0.353709156549155 1566 4016153
SGTC_102 gallobenzophenone 83.616 µM 0.375252137866181 0.348083974999507 no 1148 0.353736479010758 1762 70837
SGTC_1674 st016616 23.6 µM 0.375046966223002 0.348166015788301 no 1149 0.353812768851815 1592 625830
SGTC_1779 st039427 55 µM 0.374824393943022 0.3482550225039 no 1150 0.353895535483866 1831 1124498
SGTC_865 0488-0499 301 µM 0.373035942637061 0.348970527712384 no 1151 0.354560846615872 1705 9634651
SGTC_2272 7805186 180 µM 0.37243836422919 0.349209720628694 no 1152 0.354783247260964 1767 2956062 YPR165W RHO1
SGTC_392 N-ethylmaleimide 8.33 µM 0.371934161767811 0.349411584527013 no 1153 0.35497093470489 1647 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1613 st002381 52.1 µM 0.370815807575738 0.349859483883369 no 1154 0.355387363357404 1649 551167
SGTC_3110 9122132 49.47 µM 0.370657270759625 0.349922994595016 no 1155 0.355446409872208 1767 918317
SGTC_1009 4106-0057 9.87 µM 0.369977453608291 0.350195380634436 no 1156 0.355699644854827 1776 2928005
SGTC_1448 4255-0083 152 µM 0.369684631376185 0.350312731072018 no 1157 0.355808742103295 1802 5399660
SGTC_1451 4152-0210 104 µM 0.369450741858354 0.350406474103399 no 1158 0.35589589118066 1779 659563
SGTC_2265 7929201 200 µM 0.368078660251175 0.350956588439307 no 1159 0.356407291140137 1603 1265108
SGTC_188 3229-0966 278.469 µM 0.367917243290662 0.351021326576161 no 1160 0.35646747119926 1797 5722370
SGTC_2605 digitonin 300 nM 0.366729290537773 0.351497901665097 no 1161 0.356910477925606 1793 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3010 9080089 71.4286 µM 0.364353496883086 0.352451706887896 no 1162 0.357797028203378 1760 17027233
SGTC_787 4152-0075 138 µM 0.36161153745152 0.353553670072512 no 1163 0.358821170856653 1713 9566539
SGTC_479 n-linoleoylglycine 10 µM 0.361527192147561 0.353587587040301 no 1164 0.358852690608684 1675 6433346 An anti-infammatory.
SGTC_3308 9128332 17.569 µM 0.361372326125305 0.353649864854309 no 1165 0.358910566381894 1805 17332805 YDL196W YDL196W
SGTC_2152 5568786 200 µM 0.361033159241119 0.353786271089306 no 1166 0.359037329485921 1693 5399883
SGTC_24 0417-1663 219 µM 0.358961060676106 0.354620035401763 no 1167 0.359812109800202 1684 4329390
SGTC_1660 st012960 28.1 µM 0.358932784465581 0.354631417921314 no 1168 0.359822686578314 1687 24207266
SGTC_37 0566-0070 1.56 µM 0.358719978078384 0.354717086777112 no 1169 0.35990229071431 1793 1626686
SGTC_3245 9134821 49.47 µM 0.354844013314908 0.356278704597168 no 1170 0.361353226659039 1612 17014901
SGTC_2581 avocatin a 64 µM 0.354348421873384 0.356478551876531 no 1171 0.361538891682286 1684 6710728 A skin care supplement.
SGTC_2094 5332512 191.667 µM 0.352171971199561 0.357356671729141 no 1172 0.362354647941572 1791 755774
SGTC_1367 1812-0510 76.9 µM 0.351917617697991 0.357459343670152 no 1173 0.362450023155602 1730 1142582 YDR527W RBA50
SGTC_1125 tnp00248 1.32998 µM 0.351025036183706 0.357819723336302 no 1174 0.362784782946619 1885 24207736
SGTC_71 0417-1750 47.813 µM 0.350627302866776 0.357980348958065 no 1175 0.362933985333146 1855 6811472
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.350390217207558 0.358076108574555 no 1176 0.363022933586393 1674 61125 An anti-inflammatory.
SGTC_1433 4060-0023 7.6 µM 0.350242705928222 0.358135693334169 no 1177 0.363078279636655 1745 3840627
SGTC_2746 daunorubicin 9.88 µM 0.34902424196813 0.358628003880918 no 1178 0.363535555077623 1812 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1089 terbinafine 2.25 µM 0.346328217143728 0.359718145252136 no 1179 0.364548032500261 1788 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_662 k832-1615 104 µM 0.345718403860091 0.35996488283313 no 1180 0.364777175945383 1753 5878478
SGTC_3018 9082602 49.47 µM 0.344821570072645 0.360327858268373 no 1181 0.365114257971589 1715 17332089
SGTC_1540 guanosine 70.6 µM 0.343242703757885 0.360967178469606 no 1182 0.365707940472246 1794 6802 Guanosine is a purine nucleoside
SGTC_614 0462-0418 107 µM 0.343109875866289 0.361020981362636 no 1183 0.365757900873926 1672 5188303
SGTC_3213 9129884 49.47 µM 0.342936049815045 0.361091395009132 no 1184 0.365823285305634 1597 17190742
SGTC_657 3534-0529 86.7 µM 0.340611177962722 0.362033608282206 no 1185 0.366698156671874 1792 1049549
SGTC_1133 3473-0247 50 µM 0.339776452384404 0.362372106433123 no 1186 0.367012441146935 1632 711311
SGTC_2591 skatole 100 µM 0.339385974263768 0.362530490198018 no 1187 0.367159491593168 1713 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_185 k048-0037 25.491 µM 0.339354495600454 0.362543259439797 no 1188 0.367171347015573 1846 6827589
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.338513522636895 0.362884454605246 no 1189 0.367488119189397 1707 6708784 An antioxidant flavonoid
SGTC_2183 6420625 130.508 µM 0.337171814495663 0.363429030765174 no 1190 0.367993691653447 1680 2897619
SGTC_435 c-PAF 6.7 µM 0.336374714138488 0.363752690855424 no 1191 0.368294157447404 1809 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_210 3551-0445 56.827 µM 0.335742532070083 0.364009455555889 no 1192 0.368532514838006 1759 2865180 YOR207C RET1
SGTC_893 0958-0369 48.9 µM 0.334361167833211 0.364570717635934 no 1193 0.369053519188716 1861 6819948
SGTC_1175 0741-0056 27.6 µM 0.332075739991092 0.365499947081105 no 1194 0.369916034179656 1821 765927
SGTC_2844 9010103 25.97 µM 0.331702050707585 0.365651960259082 no 1195 0.370057126016225 1729 2480525
SGTC_2669 eugenol 100 µM 0.331691059914237 0.365656431526815 no 1196 0.370061276015329 1836 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2402 5553605 200 µM 0.330887159714651 0.365983523164202 no 1197 0.3703648606207 1786 6758546
SGTC_2641 levomentholum 100 µM 0.330755916232292 0.366036932888145 no 1198 0.370414431039625 1782 16666
SGTC_3168 9103419 49.47 µM 0.330421534220695 0.366173021859112 no 1199 0.370540736226539 1808 16649256
SGTC_1889 st059080 5.18 µM 0.32942520167708 0.366578615526611 no 1200 0.370917160839709 1858 176925 Isolated from Daphnopsis sellowiana.
SGTC_271 rotenone 740 µM 0.329316066386143 0.366623052110502 no 1201 0.370958400782541 1804 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3090 9117696 49.47 µM 0.329164458684474 0.366684785139959 no 1202 0.371015692620248 1840 7923821
SGTC_319 1348-1596 45.5 µM 0.328882760426325 0.366799498804199 no 1203 0.371122152658551 1866 5380505
SGTC_1104 tacrolimus 29.8 µM 0.32764029221085 0.367305600742198 no 1204 0.371591826627596 1765 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3051 9093778 49.47 µM 0.32709631836376 0.367527253470172 no 1205 0.371797518158273 1763 17217378
SGTC_1063 disulfiram 1.84 µM 0.326726485263666 0.367677974372912 no 1206 0.371937383169568 1750 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2200 6600604 21.907 µM 0.326696181721016 0.367690325110389 no 1207 0.371948844238063 1729 2904777
SGTC_1315 1237-0019 3.69 µM 0.326543207878315 0.367752674357217 no 1208 0.372006702033518 1817 825140
SGTC_559 1550-0661 158 µM 0.326150589425939 0.367912714165304 no 1209 0.372155211483597 1781 5830875
SGTC_2001 4023502 57.655 µM 0.325852116409588 0.368034393593838 no 1210 0.37226812278348 1769 108941 YCR052W RSC6
SGTC_1698 5-fluorocytosine 1.055 µM 0.32541736424795 0.368211654056436 no 1211 0.372432607653936 1862 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1987 st072290 61.9 µM 0.325342656211 0.368242117412467 no 1212 0.372460875163328 1748 54697379
SGTC_1781 st038725 66.3 µM 0.324425601099458 0.368616128242759 no 1213 0.372807920060141 1710 4270275 YIL048W NEO1
SGTC_1240 0356-0016 42.1 µM 0.323506988905686 0.368990898928443 no 1214 0.373155657739743 1771 4305613
SGTC_587 k089-0003 57 µM 0.322091058576601 0.369568806829014 no 1215 0.373691855933672 1854 9659696
SGTC_1116 jasmonic acid 1.58368 µM 0.321567330431071 0.369782639722992 no 1216 0.373890248392619 1811 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_975 1335-0046 28.5 µM 0.321496476910277 0.369811571591572 no 1217 0.373917090846726 1649 16486740
SGTC_166 k072-0058 166.424 µM 0.321412217745656 0.369845978393357 no 1218 0.373949012748814 1851 5846229
SGTC_754 3474-0146 171 µM 0.320839282064112 0.370079961384944 no 1219 0.37416609450576 1643 24762078
SGTC_1130 3454-2858 15.9 µM 0.320338612934277 0.370284470594612 no 1220 0.374355827593705 1678 715628 YIL048W NEO1
SGTC_2745 rifampicin 24.3 µM 0.319814211830352 0.370498712967751 no 1221 0.374554586757305 1882 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2861 9024595 19.48 µM 0.319646704900535 0.370567155849861 no 1222 0.374618082471155 1804 16482810
SGTC_1603 st002045 67.8 µM 0.319161692962696 0.370765353523766 no 1223 0.374801951819414 1857 5887985
SGTC_3149 9097855 49.47 µM 0.319074141185742 0.370801134770235 no 1224 0.374835145970854 1882 25236625 YMR079W SEC14
SGTC_2376 9072922 81.32 µM 0.31891428880709 0.37086646719292 no 1225 0.374895754375086 1775 17087968
SGTC_580 1123-0028 41 µM 0.318426850494855 0.371065708512435 no 1226 0.375080586824405 1784 1677248 YPR107C YTH1
SGTC_1892 st058411 7.36 µM 0.317342119719143 0.37150921822583 no 1227 0.37549201038792 1855 3934738
SGTC_2180 6301957 200 µM 0.316785433817569 0.371736894549699 no 1228 0.375703208773081 1862 845462
SGTC_1477 0139-0234 16 µM 0.316396762615393 0.371895881943857 no 1229 0.375850686955196 1788 620880
SGTC_175 3793-3120 23.7 µM 0.31582332913281 0.372130486919963 no 1230 0.376068304821703 1738 5322297
SGTC_1380 2291-0730 164 µM 0.315382181267045 0.37231100308768 no 1231 0.376235747157102 1715 2999191
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.313497314379159 0.373082599669199 no 1232 0.376951430375589 1702 4330530
SGTC_2400 5203494 178.7 µM 0.312591407010646 0.373453626924599 no 1233 0.377295553704923 1702 6777674
SGTC_2884 9058502 51.95 µM 0.311724876692303 0.373808636561933 no 1234 0.377624810238344 1724 6471554
SGTC_1682 st012968 530 nM 0.310353967056902 0.374370504465986 no 1235 0.378145897960907 1692 24207270
SGTC_2051 5263410 176 µM 0.308361112099898 0.37518775267867 no 1236 0.378903784594731 1835 227584
SGTC_694 1315-0438 43.2 µM 0.306862374021967 0.375802738476443 no 1237 0.379474064693488 1814 6793154
SGTC_2426 5582046 32.21 µM 0.306115444610755 0.376109348254525 no 1238 0.379758374469485 1811 2251934
SGTC_1021 4476-0760 85.3 µM 0.305792353353757 0.376241999408374 no 1239 0.379881375456693 1695 746768
SGTC_2881 9058953 51.95 µM 0.305721644111156 0.376271032359961 no 1240 0.379908296118527 1739 17122249
SGTC_1797 st048695 56.8 µM 0.305350312928533 0.376423511049222 no 1241 0.380049680131471 1868 592262 YIL048W NEO1
SGTC_823 0417-1665 178 µM 0.304783623162628 0.376656246457244 no 1242 0.380265477645092 1786 3429856
SGTC_2654 protoveratrine a 100 µM 0.304275496053691 0.376864968733626 no 1243 0.380459005985039 1811 5702278 A heart drug and vasodilator.
SGTC_2226 7298446 200 µM 0.303658080779318 0.377118631506718 no 1244 0.380694198737161 1871 3283010
SGTC_3336 9143619 71.43 µM 0.303551653548465 0.37716236210155 no 1245 0.380734744649982 1873 45595730
SGTC_2364 9055074 200 µM 0.302751759280749 0.377491086374707 no 1246 0.381039524745303 1716 6470630
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.302152925747179 0.377737240916402 no 1247 0.381267743905393 1884 77254
SGTC_1989 st071868 50.2 µM 0.301847596531599 0.377862767660368 no 1248 0.381384122657224 1908 16414057
SGTC_881 0833-0569 170 µM 0.299957502686546 0.378640108357139 no 1249 0.382104785871903 1703 5418700
SGTC_1914 st062367 72.6 µM 0.298425479267201 0.379270545742522 no 1250 0.382689222433522 1752 978205
SGTC_289 k017-0060 526 µM 0.29729832912077 0.379734580395621 no 1251 0.383119378588288 1773 5512909
SGTC_2854 9024559 71.43 µM 0.29718734790127 0.379780279456999 no 1252 0.383161740337215 1720 3163529
SGTC_294 k038-0071 157 µM 0.296652727770632 0.380000445067182 no 1253 0.383365825456867 1785 24152826
SGTC_2418 pentamidine 31.67 µM 0.295647988716758 0.380414318787486 no 1254 0.38374946063727 1776 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3287 9117173 37.0625 µM 0.293697756036771 0.381218052224156 no 1255 0.384494434577889 1859 2789709
SGTC_553 k007-0256 45.7 µM 0.293536274911892 0.381284625146096 no 1256 0.384556138299808 1808 6287000
SGTC_2711 st079103 59.1 µM 0.293199516930925 0.381423469779369 no 1257 0.384684826653202 1890 54693780
SGTC_3073 9114972 49.47 µM 0.29233438473547 0.38178023195672 no 1258 0.385015485614858 1923 41905075
SGTC_396 dithiazanine 1.25 µM 0.29208356333191 0.381883684180184 no 1259 0.385111366780655 1756 10578 An antihelmenthic.
SGTC_136 0097-0015 404.482 µM 0.291244931256786 0.382229642322817 no 1260 0.385432000530601 1919 4861337
SGTC_2255 7941087 197.44 µM 0.291179583433064 0.382256603999403 no 1261 0.385456988220883 1918 935561
SGTC_940 3232-1287 54.8 µM 0.287809982045443 0.383647629340302 no 1262 0.386746097983314 1946 1585493 YIL048W NEO1
SGTC_689 0833-0039 98 µM 0.287777284328182 0.383661134862002 no 1263 0.386758613311476 1902 5374726
SGTC_1 0258-0098 57.368 µM 0.287435221988646 0.383802429352501 no 1264 0.386889547626274 1810 6790032 YDR047W HEM12
SGTC_407 eburnamonine 100 µM 0.286713802364884 0.384100474256348 no 1265 0.387165734172508 1762 3195
SGTC_914 3820-6779 408 µM 0.286424031635614 0.384220208479285 no 1266 0.387276685388936 1761 2893481
SGTC_2061 5245884 80.95 µM 0.285877723156579 0.384445974993147 no 1267 0.387485888183237 1784 573863
SGTC_1416 3966-0321 25.3 µM 0.285809862389929 0.384474021757033 no 1268 0.387511876996505 1825 582530 YLR208W SEC13
SGTC_2459 5811157 9.22 µM 0.285532652828891 0.384588598376543 no 1269 0.387618045892907 1860 2870684 YBR192W RIM2
SGTC_1043 0916-0009 19.3 µM 0.284125913926963 0.385170188748349 no 1270 0.388156944262673 1979 3101130
SGTC_2313 7726885 200 µM 0.283253128211557 0.385531155952957 no 1271 0.388491402370457 1805 726423
SGTC_3128 9127691 49.47 µM 0.282374060359883 0.385894821574736 no 1272 0.388828351429635 1822 41316314
SGTC_2466 5983409 37.09 µM 0.282263288451359 0.3859406544374 no 1273 0.388870816537968 1790 2879657
SGTC_2765 myclobutanil 7.74 µM 0.281758103499471 0.386149699384644 no 1274 0.389064499197531 1804 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_519 k048-0011 62.8 µM 0.281666083006918 0.386187780918603 no 1275 0.389099781867657 1830 6836379
SGTC_2308 7584454 197.62 µM 0.281491785848962 0.386259914630159 no 1276 0.389166613717729 1898 893577
SGTC_962 1254-0300 21.5 µM 0.280957705590995 0.386480970766769 no 1277 0.38937141986333 1801 7340576
SGTC_2839 9003951 25.97 µM 0.280909171356029 0.386501060942844 no 1278 0.389390033027711 1938 2990634
SGTC_2060 5238662 140 µM 0.28061044451423 0.386624722104689 no 1279 0.389504602113657 1782 790130
SGTC_1814 st052110 31.539 µM 0.280338097745018 0.386737472987771 no 1280 0.389609062163138 1915 674163
SGTC_860 0443-0016 25.1 µM 0.278380017471664 0.387548394266652 no 1281 0.390360328624711 1918 5337942
SGTC_2316 5844804 197.44 µM 0.278319274828599 0.387573558151506 no 1282 0.390383640623021 1946 776813
SGTC_2149 5554786 194.827 µM 0.277757433060052 0.387806334993633 no 1283 0.390599284655649 1817 745063 YPR165W RHO1
SGTC_863 0466-0191 129 µM 0.276698842198275 0.388245029618692 no 1284 0.39100568048369 1914 765160 YPR165W RHO1
SGTC_226 1,3-diallylurea 8.28947 mM 0.274726006251461 0.38906298018502 no 1285 0.391763374779018 1849 74537 YKL182W FAS1
SGTC_3160 9100216 49.47 µM 0.273734396993162 0.389474293803449 no 1286 0.392144371002901 1929 17191039
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.273014724070507 0.389772887434977 no 1287 0.392420948609478 1886 616764
SGTC_1206 3978-0017 132 µM 0.270066663668516 0.390996720593987 no 1288 0.393554484008612 1893 3873677
SGTC_2298 7976326 193.81 µM 0.269173039754264 0.391367906070428 no 1289 0.393898263009903 1896 2235818
SGTC_3117 9124945 49.47 µM 0.268340200665244 0.391713932383233 no 1290 0.394218732421635 1743 17592065
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.26789721538756 0.39189801794375 no 1291 0.394389218590888 1948 6708630 An antioxidant.
SGTC_1557 sumaresinolic acid 42.3 µM 0.267517141274502 0.392055979632882 no 1292 0.394535509060424 1793 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3165 9101544 49.47 µM 0.267283080925598 0.392153265746187 no 1293 0.394625606255994 1902 5002184
SGTC_2279 7948423 32.93 µM 0.266970575189886 0.392283167834537 no 1294 0.394745908336262 1986 1247112
SGTC_2981 9013952 38.96 µM 0.266093819516626 0.392647680843561 no 1295 0.39508347738921 1709 2996344
SGTC_2584 androsterone 48.74 µM 0.264283682009465 0.393400546930796 no 1296 0.395780666639613 1883 2754130 A steroid.
SGTC_1032 k061-1018 98.7 µM 0.264269435777296 0.393406473759245 no 1297 0.395786155018239 1971 4005393
SGTC_2792 7535235 81.82 µM 0.263087323759013 0.393898351142039 no 1298 0.396241637033421 1765 1281891
SGTC_279 1273-0055 2.93 µM 0.262019107039358 0.394342982294887 no 1299 0.396653355691368 1961 2847562
SGTC_2662 daunorubicin 22.37 µM 0.261793724612962 0.39443681237625 no 1300 0.396740238710985 1847 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1998 st075797 76.8 µM 0.259736561105681 0.395293522833582 no 1301 0.397533494277119 1957 24208315
SGTC_831 k061-1017 217 µM 0.259645635386211 0.395331400772208 no 1302 0.397568565629889 1942 1240153
SGTC_329 k048-0121 21.3 µM 0.259573399039687 0.395361493775721 no 1303 0.397596428813946 1829 6832902
SGTC_1119 parthenolide 318.541 nM 0.258881192100824 0.395649892490623 no 1304 0.39786345507466 1912 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_208 k072-0098 12.366 µM 0.258440184036003 0.395833662383851 no 1305 0.398033603636111 1888 5948901
SGTC_994 3910-0338 138 µM 0.257870424972256 0.396071117633055 no 1306 0.398253455274925 1928 3479481
SGTC_1235 benzylparaben 21.5 µM 0.257850119988417 0.396079580738095 no 1307 0.398261290909555 1865 7180
SGTC_1992 st073643 23.3 µM 0.256907076021675 0.396472694796197 no 1308 0.398625254001491 1820 3161292
SGTC_1494 4358-1428 177 µM 0.255253179263599 0.397162386476734 no 1309 0.399263779939821 2006 1564571
SGTC_1875 nocodazole 6 µM 0.254482622973586 0.397483826238476 no 1310 0.399561363579937 1994 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1523 st012844 44.7 µM 0.252162806700306 0.398451963753114 no 1311 0.400457612625508 1852 4274103
SGTC_220 paclitaxel 373.376 µM 0.251939931154394 0.398545010249368 no 1312 0.400543747126897 1933 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2107 5363541 170.161 µM 0.251306541835306 0.398809470266491 no 1313 0.400788558888612 1909 244052
SGTC_1668 st014914 51.6 µM 0.246625703958198 0.400765300583837 no 1314 0.402598955009686 1921 2839556
SGTC_2639 lactacystin 53 µM 0.246500309805377 0.400817729448367 no 1315 0.402647482323308 1946 3870 A proteasome inhibitor.
SGTC_1596 piperlongumine 63 µM 0.246489022962846 0.400822448706134 no 1316 0.402651850384843 1998 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1443 4112-3303 14 µM 0.246290126405025 0.400905613765033 no 1317 0.40272882628852 1857 704433
SGTC_563 tetrahydrosecaminediol 614 µM 0.245053004971782 0.401422994795625 no 1318 0.403207695101434 1989 334274 A psychoactive constituent of the cannabis plant.
SGTC_2310 7668677 200 µM 0.244648212098319 0.401592322268786 no 1319 0.403364415146762 1902 2197143
SGTC_1669 st015249 58.4 µM 0.244327861818019 0.401726339960134 no 1320 0.403488453309929 2021 722793
SGTC_1331 1472-0049 76.2 µM 0.242939362804204 0.402307348268756 no 1321 0.404026185860792 1829 24051409
SGTC_3126 9127922 49.47 µM 0.242174425552588 0.402627523561998 no 1322 0.404322505379381 1910 45595682
SGTC_2495 cafestol 54.53 µM 0.241232340374637 0.403021936366256 no 1323 0.404687523450492 1921 16667697 An anti-infammatory.
SGTC_589 1227-0070 34.1 µM 0.241113861451515 0.403071545674318 no 1324 0.404733434890091 1912 2841384
SGTC_1318 1280-3875 124 µM 0.240861252747109 0.403177322801735 no 1325 0.404831326968538 1906 373245
SGTC_1565 sinapyl alcohol 95.1 µM 0.240706748701307 0.403242023170688 no 1326 0.404891204017797 1816 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1260 0700-1617 7.75 µM 0.239343707296518 0.403812927206013 no 1327 0.40541953827576 1889 2853078
SGTC_2972 9093619 59.92 µM 0.239224748273773 0.403862762424162 no 1328 0.405465656679442 1787 25236256
SGTC_1199 1638-0010 4.46 µM 0.237650409308193 0.404522443166139 no 1329 0.406076124687101 1832 3111136
SGTC_2651 TUB2.036 5 µM 0.237497687477786 0.404586451263353 no 1330 0.406135356508219 2002 15992207 YFL037W TUB2
SGTC_1882 5615643 20 µM 0.237445446840766 0.404608346714004 no 1331 0.406155618073856 1984 2253075
SGTC_3034 9090421 49.47 µM 0.237143060912572 0.404735090625042 no 1332 0.40627290359237 1994 17173761
SGTC_1194 1488-0194 225 µM 0.236288453275034 0.405093350167654 no 1333 0.406604423122856 1887 1391452
SGTC_1263 0774-1208 64.8 µM 0.235694855291883 0.405342238848867 no 1334 0.406834731162735 2020 906585
SGTC_2779 methotrexate 400 µM 0.235077993120099 0.405600922493954 no 1335 0.40707409953741 2002 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1984 st072354 53.1 µM 0.234323216874882 0.405917497045568 no 1336 0.407367031566286 1914 5762938
SGTC_1046 2001-0062 216 µM 0.233158862765894 0.406405980773841 no 1337 0.407819024151776 1840 739778
SGTC_2109 5483026 200 µM 0.232901749742925 0.406513867562452 no 1338 0.407918849852124 1877 759335
SGTC_2545 solidagenone 89.61 µM 0.232456025211778 0.406700914138709 no 1339 0.408091919282331 1922 6708572 An anti ulcer agent
SGTC_1439 4092-1168 46 µM 0.232248409387406 0.406788046586296 no 1340 0.408172540113096 1941 2886240
SGTC_1402 3909-7673 35.9 µM 0.23127742865978 0.407195610080996 no 1341 0.408549640346962 1897 5328014
SGTC_389 tpck 16.7 µM 0.231196838054504 0.407229442040258 no 1342 0.408580943168657 1878 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3289 9119912 71.43 µM 0.230860236895574 0.407370754783079 no 1343 0.408711691337074 1908 17014829
SGTC_2706 st078239 82.5 µM 0.230364161624344 0.407579040319801 no 1344 0.408904403585507 1952 15434492
SGTC_1931 st074438 57.1 µM 0.229017142183333 0.408144740702472 no 1345 0.409427796318896 2012 2787313
SGTC_3125 9127534 49.47 µM 0.228327404703877 0.408434480190065 no 1346 0.409695860652999 2039 1639235
SGTC_3272 9137413 49.47 µM 0.226809581989689 0.409072251284795 no 1347 0.410285906256662 1901 17614870
SGTC_151 3013-0144 2.285 µM 0.226320104669494 0.409277975274788 no 1348 0.410476231377389 2009 906558 YHR107C CDC12
SGTC_64 000l-0018 272.079 µM 0.225146964513648 0.409771139718349 no 1349 0.410932473173915 1849 6811119
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.22456217629178 0.410017026259417 no 1350 0.411159946147098 1934 6708739 YPR165W RHO1
SGTC_729 4092-0585 94.1 µM 0.223617336246754 0.410414378918418 no 1351 0.411527536435307 1839 2169061
SGTC_1173 0443-0020 122 µM 0.223512309700701 0.410458553539979 no 1352 0.411568401845516 1873 5331295
SGTC_2465 5809242 33.21 µM 0.223247527367879 0.410569927180528 no 1353 0.411671431852208 1953 2731748
SGTC_1510 1123-0200 71.5 µM 0.223063410602542 0.410647375248576 no 1354 0.411743077501757 1997 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1815 st051655 58.2 µM 0.221894504916243 0.4111391524568 no 1355 0.412198004175165 2044 5984156
SGTC_316 k060-0003 58.6 µM 0.219447900601806 0.412168929070527 no 1356 0.413150579978816 2000 6152314
SGTC_1053 3366-3204 134 µM 0.21867263452219 0.41249536540911 no 1357 0.413452533783637 1851 3632071 YPR165W RHO1
SGTC_1525 8-methoxypsoralen 92.5 µM 0.21819527770171 0.412696393125682 no 1358 0.413638482147908 2059 4114 Related to psoralen; DNA damaging agent.
SGTC_1222 0366-0074 1.18 µM 0.216882428546118 0.413249386944772 no 1359 0.414149985840477 2030 286520
SGTC_836 0330-0104 1.35 µM 0.215250818238943 0.413936888056333 no 1360 0.414785886078652 1986 46494820
SGTC_1844 rapamycin 4 nM 0.213005084412542 0.41488358955145 no 1361 0.415661498450168 1930 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_109 0132-0036 33.701 µM 0.212791510996122 0.414973648441481 no 1362 0.415744792679145 2050 67274 A color developer.
SGTC_2511 berberine 10.47 µM 0.212527554358218 0.41508495892527 no 1363 0.415847741735244 1890 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_80 0159-0065 512.242 µM 0.211082889727674 0.415694294355602 no 1364 0.41641129572577 2045 1548079
SGTC_1232 0279-0259 161 µM 0.210212282167897 0.416061600104984 no 1365 0.416750996972882 1868 1560000
SGTC_2297 7971671 152.32 µM 0.210088187219292 0.416113961231858 no 1366 0.416799422490231 2010 909016
SGTC_814 3342-0569 96 µM 0.206344367272371 0.417694339774708 no 1367 0.418260962038724 1974 4346283
SGTC_2213 7173844 200 µM 0.205469423922828 0.418063872278992 no 1368 0.418602692312356 1930 892728
SGTC_1570 verbenone 133 µM 0.202380219950641 0.419369174745702 no 1369 0.419809745325715 2067 29025 A natural terpanoid with antifungal properties.
SGTC_3013 9080133 71.4286 µM 0.202294830872624 0.419405267451725 no 1370 0.419843120402919 1994 17050193
SGTC_3086 9117350 49.47 µM 0.201538638758608 0.419724928284207 no 1371 0.420138709919335 2014 2679265
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.201234936840636 0.419853325407523 no 1372 0.420257437286368 1888 2374 Ca(2+)-ATPase inhibitor.
SGTC_231 b-estradiol 524 µM 0.198845770677381 0.420863698053749 no 1373 0.421191695504932 1923 450 A steroid.
SGTC_3156 9099931 49.47 µM 0.198431424193033 0.421038977437827 no 1374 0.421353766641951 1937 18111053
SGTC_557 1315-0110 16.2 µM 0.197752214457114 0.421326334737356 no 1375 0.421619467540127 1967 6833801
SGTC_753 1322-0200 289 µM 0.197504581403262 0.421431112758436 no 1376 0.421716348305689 1971 5403907
SGTC_2531 methyl deoxycholate 70.07 µM 0.197479610974795 0.421441678506981 no 1377 0.421726117677499 1929 16667744 Haematoxylin.
SGTC_1694 st024011 44.9 µM 0.197351264754566 0.421495986592837 no 1378 0.421776332311417 2051 2787533
SGTC_485 niflumic acid 177 µM 0.197059676888496 0.421619373872932 no 1379 0.421890418916336 2024 4488 A COX2 inhibitor.
SGTC_465 cgp-37157 41 µM 0.196873503417771 0.421698158400296 no 1380 0.421963264537551 2076 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1277 0873-0036 22 µM 0.196550412289189 0.421834890913653 no 1381 0.422089689390105 2023 5965735
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.195453940528273 0.422298989104634 no 1382 0.422518796175834 1935 688803
SGTC_1935 st074532 41.6 µM 0.195050545623458 0.42246975926052 no 1383 0.422676688883333 2084 2829742
SGTC_2234 tolnaftate 200 µM 0.194090965215837 0.422876039301391 no 1384 0.423052327912694 2060 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_619 1652-1634 108 µM 0.193964770455859 0.422929475447292 no 1385 0.423101733547722 1931 5400454
SGTC_2625 euphol 100 µM 0.193614877486297 0.423077642196176 no 1386 0.42323872403951 2076 6708538 A triterpene alcohol.
SGTC_1500 4488-1866 171 µM 0.190585250823877 0.424361029993796 no 1387 0.424425273259463 2065 2900003
SGTC_631 k072-0230 41.5 µM 0.19004522870606 0.424589874777832 no 1388 0.424636844464249 2015 5773147
SGTC_1631 benzylvanillin 81.9 µM 0.188809289712467 0.425113723304716 no 1389 0.425121145331932 1976 75506
SGTC_828 2074-0507 139 µM 0.188516878932519 0.425237679997013 no 1390 0.425235742624391 2061 X828
SGTC_2748 diazoxide 86.69 µM 0.187858362555516 0.425516860609612 no 1391 0.425493841706429 2046 3019 A potassium channel activatior.
SGTC_921 1561-0023 372 µM 0.1872521787164 0.425773887653969 no 1392 0.425731457787671 1953 24050882
SGTC_2190 6049624 200 µM 0.186989823730261 0.42588513815974 no 1393 0.425834305855035 2045 2265554
SGTC_1394 3474-0001 65.7 µM 0.186159656538794 0.426237205821829 no 1394 0.426159780150212 1965 5017666 YIL048W NEO1
SGTC_1722 st034304 3.6505 µM 0.185805978162456 0.426387216037498 no 1395 0.426298458138745 1960 4036148 YLR033W RSC58
SGTC_3048 9093155 49.47 µM 0.185312427842018 0.426596569759171 no 1396 0.42649199542122 2094 25236002
SGTC_2427 5545055 42.75 µM 0.183841572156445 0.427220598411553 no 1397 0.427068871026622 1996 5372858
SGTC_1124 fisetin 1.16336 µM 0.183841176987562 0.427220766091368 no 1398 0.427069026034488 1910 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1793 st048256 72.231 µM 0.183039570732738 0.427560934240709 no 1399 0.427383485061778 2077 672022
SGTC_2721 ifenprodil 61.44 µM 0.182723453229826 0.427695096101612 no 1400 0.427507506275353 2066 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2243 6634756 200 µM 0.182382933955747 0.427839623550407 no 1401 0.427641108960204 2081 885676
SGTC_2196 6573537 42.6665 µM 0.181971051568149 0.428014452761215 no 1402 0.427802722038557 2093 2903087
SGTC_505 gw-5074 63.9 µM 0.181855820834741 0.428063366580837 no 1403 0.427847938070496 2052 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1419 3993-2473 62.6 µM 0.180798243132737 0.428512344920258 no 1404 0.428262971081126 2010 704026
SGTC_1493 4348-0038 111 µM 0.180274987263453 0.428734519403887 no 1405 0.428468345613473 2039 800424
SGTC_2710 st078562 53.7235 µM 0.17947461614872 0.42907440071344 no 1406 0.428782523543747 2054 17250908
SGTC_1354 1498-1681 81 µM 0.179039160778946 0.429259340965642 no 1407 0.4289534763025 1976 5754243
SGTC_3312 9133330 71.43 µM 0.178909405667212 0.429314451668661 no 1408 0.42900441864669 2075 17617324
SGTC_1872 amphotericin b 148 nM 0.178239199733102 0.429599129189978 no 1409 0.429267562824715 2064 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2339 9000433 200 µM 0.177207243593689 0.430037535723946 no 1410 0.429672803072904 1914 2988954
SGTC_638 3970-0837 4.09 µM 0.176696568152961 0.430254518215251 no 1411 0.429873368339075 1945 4118451 YLR208W SEC13
SGTC_1393 3470-5649 58.2 µM 0.176039916118301 0.43053355610592 no 1412 0.430131291785483 2001 4108395
SGTC_1697 st025554 27.742 µM 0.175688665230781 0.430682831001204 no 1413 0.43026927031431 1991 1269519
SGTC_2666 tannic acid 100 µM 0.173699209634817 0.431528497811319 no 1414 0.431050929351352 2050 16134267 A thiamine antagonist.
SGTC_1007 4101-0031 70 µM 0.171873641264954 0.432304776655824 no 1415 0.431768434706151 2102 1146276
SGTC_2791 5663188 71.43 µM 0.171787750431168 0.432341306119821 no 1416 0.431802198049167 2065 54690634
SGTC_1761 st044296 37 µM 0.171321719570166 0.432539519620949 no 1417 0.431985401594026 2031 1826700
SGTC_2515 chrysin 20.77 µM 0.171218558458553 0.432583398679645 no 1418 0.432025957713974 2074 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_2920 7982904 15.77 µM 0.170216858449362 0.433009509879105 no 1419 0.43241979703167 1993 6456808
SGTC_1049 3226-0134 66 µM 0.169238014864936 0.433425973489761 no 1420 0.43280471474724 2094 5702385
SGTC_2221 6807166 181.081 µM 0.168493811983446 0.433742655210595 no 1421 0.433097405700068 2073 674925
SGTC_295 k015-0027 31 µM 0.168188463475049 0.433872602918473 no 1422 0.433217508238933 2042 3887424
SGTC_2691 st077356 60.2 µM 0.167632192147595 0.434109354657903 no 1423 0.433436321940369 2064 2839272
SGTC_3335 9143315 29.6265 µM 0.166984431284771 0.434385074564306 no 1424 0.433691149480618 1973 4899691
SGTC_1710 st031758 61.5 µM 0.166856011558275 0.434439740314671 no 1425 0.433741672764579 2110 5394341
SGTC_2551 apiole 73.87 µM 0.166582943220146 0.43455598429791 no 1426 0.433849107747911 2104 10659 A possible DNA adduct former.
SGTC_2982 9019404 25.97 µM 0.166072816850627 0.434773157986618 no 1427 0.434049823041233 1815 22333232
SGTC_307 1501-1223 22.3 µM 0.165729779785108 0.434919208607068 no 1428 0.43418480462407 2035 2830329
SGTC_137 0438-0332 85.389 µM 0.164967911132264 0.435243611672973 no 1429 0.434484619586408 2092 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1838 st055369 84.5 µM 0.164920525045576 0.435263790073069 no 1430 0.434503268480103 2123 676036
SGTC_2139 5578692 56.4705 µM 0.164365894480008 0.435499980725329 no 1431 0.434721555326175 2139 650991 YMR113W FOL3
SGTC_456 gingerol 170 µM 0.163913796238309 0.435692524788029 no 1432 0.434899503085308 2050 442793 A herb.
SGTC_584 0986-0246 15.4 µM 0.163479812230947 0.435877368523146 no 1433 0.435070333411827 2135 53315 YDR232W HEM1
SGTC_492 tmb-8 126 µM 0.163403510325815 0.435909868702343 no 1434 0.435100369595736 2117 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1850 st056238 17 µM 0.162139421548908 0.436448359905596 no 1435 0.435598031497358 2120 5393177
SGTC_402 epigallocatechin gallate 10 µM 0.161902015075129 0.436549506239392 no 1436 0.435691507977861 1975 65064 An antioxidant.
SGTC_3203 9113543 49.47 µM 0.16053302393846 0.437132841646108 no 1437 0.436230604805233 2023 17018012
SGTC_969 1313-0238 134 µM 0.160517454741247 0.437139476563815 no 1438 0.436236736503265 2001 5212874
SGTC_1452 4194-0072 190 µM 0.158902929034135 0.437827613148105 no 1439 0.436872676491632 2129 1343545
SGTC_3116 9124943 49.47 µM 0.157779431108286 0.438306576963925 no 1440 0.437315303609999 1915 41905195 YPL160W CDC60
SGTC_3256 9138902 49.47 µM 0.156102785267434 0.439021523808163 no 1441 0.437976001476721 2134 17228773
SGTC_867 0518-0118 155 µM 0.156048110274863 0.439044841404964 no 1442 0.437997549587044 2171 6848158
SGTC_78 0336-0123 156.75 µM 0.153469097317911 0.440144968621124 no 1443 0.439014179179123 1931 6765896
SGTC_3175 9106517 49.47 µM 0.153204989999327 0.440257654876318 no 1444 0.439118311339975 2019 41468073
SGTC_1805 st050013 60.3 µM 0.152877893468251 0.440397223346843 no 1445 0.439247284710162 2098 4037144
SGTC_3187 9109394 49.47 µM 0.152640526694782 0.440498509760511 no 1446 0.439340881893327 1989 17098090
SGTC_1828 st055811 49 µM 0.15228864953438 0.440648665888276 no 1447 0.439479638431711 2148 5877589
SGTC_901 1112-0062 60.1 µM 0.151943430774813 0.440795988978317 no 1448 0.439615776573532 2065 1908457
SGTC_2837 9008476 45.46 µM 0.150682818672906 0.441334028232052 no 1449 0.440112963591189 2059 2992805
SGTC_358 0075-0058 9.45 µM 0.150266246080806 0.441511848574557 no 1450 0.440277281152416 2226 1069125
SGTC_1286 0929-0070 131 µM 0.150196145949364 0.441541773041001 no 1451 0.440304933245644 2081 1420408
SGTC_516 3992-2719 87.3 µM 0.1489363778932 0.44207960174684 no 1452 0.440801917959795 2030 5350887 YDR037W KRS1
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.148879980671846 0.442103681735002 no 1453 0.440824169128521 1984 6708561
SGTC_2481 5478948 45.16 µM 0.148392955887548 0.442311636173444 no 1454 0.441016329457599 2027 77792
SGTC_3042 9091578 49.47 µM 0.147516283974443 0.442686005846123 no 1455 0.441362263791872 2145 25236497
SGTC_1733 st037357 54.9 µM 0.146735782648111 0.443019350381313 no 1456 0.44167028691228 2034 1272339 YGL099W LSG1
SGTC_433 pimozide 108 µM 0.14660262493529 0.443076224781245 no 1457 0.441722840836727 1918 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1499 4480-0877 67.3 µM 0.144839969949324 0.443829201084306 no 1458 0.442418611749573 2150 2861909
SGTC_2291 7917025 104.35 µM 0.144809297447138 0.44384230566012 no 1459 0.442430720652225 2023 2964612
SGTC_1389 3405-0187 19 µM 0.144425763376299 0.444006172636401 no 1460 0.442582136923062 1997 799890
SGTC_2040 5100729 123 µM 0.142690842652943 0.444747545957477 no 1461 0.443267174606817 2082 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_852 0418-0143 439 µM 0.142574578772642 0.444797235248341 no 1462 0.443313087770156 2172 5369229
SGTC_2713 st079149 53.4 µM 0.142243365055807 0.444938795355237 no 1463 0.443443889824108 2067 3103253
SGTC_124 0136-0217 7.121 µM 0.140267834273923 0.445783278659853 no 1464 0.444224188782903 2200 3976905
SGTC_2693 st077581 40.7 µM 0.140207192183439 0.445809205342831 no 1465 0.444248144749044 2194 25238761
SGTC_1553 gossypol 38.6 µM 0.139214186298703 0.446233784092611 no 1466 0.444640449309636 2148 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2842 9000675 19.48 µM 0.139191156157351 0.446243631805528 no 1467 0.444649548419817 1944 2989072
SGTC_3142 9086498 49.47 µM 0.138852728670779 0.446388347578863 no 1468 0.444783263030991 2176 25236367
SGTC_1853 st056710 91.2 µM 0.138699582135412 0.446453837276965 no 1469 0.444843774158006 2201 269167
SGTC_1810 st050138 53 µM 0.137466073869603 0.446981372664398 no 1470 0.4453312036304 2181 3444541
SGTC_343 4130-2827 29.8 µM 0.136908077267342 0.447220042359503 no 1471 0.445551727111714 2027 1118244
SGTC_3123 9126162 49.47 µM 0.136809044469789 0.447262403268796 no 1472 0.445590867207814 2109 25239884
SGTC_1202 1988-0068 29.6 µM 0.13609435949794 0.44756812490414 no 1473 0.445873343255266 1996 2850480
SGTC_178 4092-0806 87.505 µM 0.135323418255814 0.447897946273314 no 1474 0.446178085144017 2171 2169044
SGTC_1934 st074720 32.6 µM 0.135140310661389 0.447976288022714 no 1475 0.446250469598886 2135 17250992
SGTC_3174 9107204 49.47 µM 0.134323215429049 0.448325903181172 no 1476 0.446573498167494 2127 3938802
SGTC_2735 sertaconazole 140 nM 0.133822119535327 0.44854032978843 no 1477 0.446771617829922 2195 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_487 nimodipine 119 µM 0.133732980602698 0.448578475279716 no 1478 0.446806862328324 2185 4497 L-type voltage-gated calcium channels inhibitor
SGTC_3118 9124250 49.47 µM 0.133384087960182 0.448727782525102 no 1479 0.446944814463865 2069 1504786
SGTC_233 rapamycin 362 pM 0.12915308748634 0.450538994509506 no 1480 0.448618257992156 2178 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1856 st057054 55.7 µM 0.12772452574545 0.451150769610455 no 1481 0.449183490158803 2187 1266018
SGTC_926 2268-1401 59.4 µM 0.125507135922508 0.452100586117439 no 1482 0.45006103803059 2195 2931578
SGTC_3301 9125354 19.7965 µM 0.12541479962609 0.452140144253793 no 1483 0.450097586106693 2135 41905162
SGTC_1756 st041558 35.5 µM 0.124727232063735 0.452434722547063 no 1484 0.450369748838236 2222 3955792
SGTC_3176 9106582 49.47 µM 0.124513479381332 0.452526307109062 no 1485 0.450454364214733 2177 17018027
SGTC_2753 fluvastatin 17.09 µM 0.124068166910215 0.452717113979913 no 1486 0.450630651254151 2110 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2560 caryophyllene 100 µM 0.122100397098982 0.453560391395586 no 1487 0.451409753696836 2222 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1548 st061468 90.8 µM 0.121553660697936 0.453794729749273 no 1488 0.451626257330062 2175 390799
SGTC_879 0831-1030 162 µM 0.121529762714825 0.453804973104135 no 1489 0.451635721086017 2133 1549252
SGTC_2386 9075165 157.42 µM 0.120829032796958 0.454105339497542 no 1490 0.451913226864128 2105 16452277
SGTC_2764 methyldopa 94.69 µM 0.119473343794355 0.454686527082838 no 1491 0.452450178662955 2171 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2803 7707263 71.43 µM 0.118598156138864 0.455061774036654 no 1492 0.452796863115382 2097 2199229
SGTC_635 k038-0028 24.7 µM 0.118458480709726 0.455121665231534 no 1493 0.452852195499918 2123 4035102
SGTC_938 3126-1755 342 µM 0.118390151703834 0.45515096428394 no 1494 0.452879264351192 2202 1777771
SGTC_1306 1185-0270 9.02 µM 0.117629876084145 0.455476982159979 no 1495 0.45318046579408 2166 1548076
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.11700544393352 0.455744770704798 no 1496 0.453427869740608 2152 5377381
SGTC_118 0083-0097 135.343 µM 0.11665614249138 0.455894577862588 no 1497 0.453566273059748 2158 5207356
SGTC_2752 diclazuril 33.15 µM 0.116607808027803 0.455915307869445 no 1498 0.453585425014681 2189 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1957 st077035 62.4 µM 0.116303694243305 0.4560457409668 no 1499 0.453705928950464 2222 705593
SGTC_339 3091-4833 71.4 µM 0.114419529107834 0.456853956360251 no 1500 0.454452616835278 2135 3240077
SGTC_2324 6149169 200 µM 0.113894663192035 0.457079130295575 no 1501 0.454660648097106 2177 2888231
SGTC_1236 0330-0013 258 µM 0.11304261618746 0.457444698255483 no 1502 0.454998384448565 2097 4617066
SGTC_445 e6 berbamine 66 µM 0.11062277855172 0.458483116949908 no 1503 0.455957741837688 2126 6610268 A calcium/calmodulin antagonist.
SGTC_3021 9087658 49.47 µM 0.110547287658904 0.458515516757573 no 1504 0.455987674760315 2216 25237042
SGTC_1811 st050069 61.5 µM 0.110112286877874 0.45870221936477 no 1505 0.456160161947165 2231 3877702
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.110062615290807 0.458723539021309 no 1506 0.456179858328378 2197 91467 include heat shock
SGTC_1138 3761-0006 1.03 µM 0.109645476417803 0.458902584839153 no 1507 0.456345271547094 2209 12061087
SGTC_2781 5567276 71.43 µM 0.109039047274661 0.459162893355125 no 1508 0.456585759856538 2165 2853274
SGTC_2912 7964298 10.93 µM 0.108601854501171 0.459350568360976 no 1509 0.456759144888674 2108 2975850
SGTC_355 1311-2252 105 µM 0.108431448945311 0.459423721302516 no 1510 0.45682672777245 2079 5338538
SGTC_2601 securinine 100 µM 0.107521375847721 0.459814427328872 no 1511 0.457187684074185 2129 442872 A GABA receptor antagonist.
SGTC_2828 7998861 71.43 µM 0.107393885026862 0.459869163877471 no 1512 0.457238252746669 2219 2988188
SGTC_410 α-linolenic acid 100 µM 0.106822978237908 0.46011428469865 no 1513 0.457464708890312 2182 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2380 9035439 200 µM 0.10554484613588 0.460663109996577 no 1514 0.457971743306699 2180 6462575
SGTC_2156 5649887 115 µM 0.105432914537433 0.46071117660374 no 1515 0.458016149789638 2190 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2198 6589944 200 µM 0.103936055429468 0.461354025307981 no 1516 0.458610046976028 2179 5290268
SGTC_2119 5528445 120.635 µM 0.102746037014948 0.461865168794936 no 1517 0.459082267355781 2190 791935
SGTC_2847 9005661 71.43 µM 0.100508636064725 0.462826359883432 no 1518 0.459970263484751 2243 2991449
SGTC_2873 9040596 71.43 µM 0.100151567608533 0.46297977730581 no 1519 0.460111998030831 2068 6463863
SGTC_988 1497-1057 103 µM 0.0993172715513984 0.463338260948102 no 1520 0.460443182750373 2245 3533044
SGTC_699 0375-0592 111 µM 0.0989274598348732 0.463505767017025 no 1521 0.460597933024541 2268 762578
SGTC_2306 7482397 179.52 µM 0.0981024832851941 0.463860289151277 no 1522 0.460925457832009 2209 891448
SGTC_382 3229-0966 23.2 µM 0.0974240182890088 0.464151871513404 no 1523 0.461194835808157 2223 5722370
SGTC_3041 9091929 49.47 µM 0.0972800294677613 0.464213755744528 no 1524 0.461252007474042 2186 25236887
SGTC_3194 9111903 49.47 µM 0.096302572535847 0.464633874852933 no 1525 0.461640133998663 2198 17087251
SGTC_2952 9073731 13.78 µM 0.0959775086269252 0.46477359878104 no 1526 0.461769217799787 2162 16457353
SGTC_2942 9052777 62.25 µM 0.0956497914236649 0.46491446758564 no 1527 0.461899359308357 2177 6469503
SGTC_2428 5615643 7.78 µM 0.0953660680282077 0.465036429262558 no 1528 0.462012033498956 2188 2253075
SGTC_333 3486-0131 40.1 µM 0.0950922995316075 0.465154114828676 no 1529 0.462120757221753 2238 6744690
SGTC_2489 cantharidin 73.42 µM 0.0941202717837511 0.465571987442998 no 1530 0.462506808653851 2235 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1986 st071812 45 µM 0.0939688472517457 0.465637087949304 no 1531 0.462566951748793 2239 11838594
SGTC_758 0868-0029 16 µM 0.0930622774707737 0.466026860030943 no 1532 0.46292704277798 2265 762687
SGTC_3191 9110352 49.47 µM 0.0906236716457312 0.467075478868865 no 1533 0.463895811035459 2238 17122424
SGTC_2947 9072639 7.68 µM 0.090259300303261 0.467232181088991 no 1534 0.464040580872331 2180 16488146
SGTC_2804 7954240 19.48 µM 0.089782738502312 0.467437139808486 no 1535 0.464229932732413 2215 828705
SGTC_1769 st044406 64.4 µM 0.0896368812536147 0.467499871522166 no 1536 0.464287887679578 2094 670903
SGTC_2273 7815444 169.05 µM 0.088937198855752 0.467800808974743 no 1537 0.464565910131723 2265 2824616
SGTC_575 k072-0246 11.9 µM 0.0887112609286759 0.467897990125119 no 1538 0.464655691448089 2229 6796779
SGTC_1490 4089-0339 670 nM 0.0884297787556612 0.468019064821697 no 1539 0.464767546987499 2258 742542
SGTC_1485 3909-9022 254 µM 0.0883426649400044 0.46805653592535 no 1540 0.46480216488766 2230 714516
SGTC_1862 st057513 3.81 µM 0.0872781663757219 0.468514441693951 no 1541 0.465225204246239 2230 5393163
SGTC_1115 galangin 695.678 nM 0.0871141136156192 0.468585014513325 no 1542 0.465290403496271 2233 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3236 9132701 49.47 µM 0.0862067636215236 0.46897535943783 no 1543 0.465651027066897 2152 24282524
SGTC_3293 9120939 62.045 µM 0.0861752633886798 0.468988911478494 no 1544 0.465663547249607 2216 934087
SGTC_3267 9137951 49.47 µM 0.0849884680674634 0.469499520995175 no 1545 0.466135279343485 2121 16643986
SGTC_336 4111-0029 111 µM 0.0849221342641099 0.469528062089587 no 1546 0.466161647375998 2156 3131175
SGTC_225 nsc-122657 1.016 µM 0.0845037226796357 0.469708093429657 no 1547 0.466327971579923 2222 275685
SGTC_561 1550-0330 72.9 µM 0.0838973811892307 0.469968996973643 no 1548 0.466569010864798 2181 6812934
SGTC_2006 4011487 200 µM 0.0838277560259428 0.469998956911763 no 1549 0.466596689782922 2239 45595294
SGTC_2374 9071832 200 µM 0.0836930444438089 0.470056924233307 no 1550 0.466650243736729 2251 17381698
SGTC_427 1354-0053 47.3 µM 0.0836455826941821 0.470077347502272 no 1551 0.466669112075222 2200 6813657
SGTC_2762 leflunomide 42.06 µM 0.0832455746960869 0.470249478095393 no 1552 0.466828137551893 2195 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_44 0929-0055 61.211 µM 0.082753360177665 0.470461294428525 no 1553 0.467023827524695 2185 1379590
SGTC_352 k048-0007 5.11 µM 0.0824525429912572 0.470590750221147 no 1554 0.467143427491666 2245 6811911
SGTC_3074 9116018 49.47 µM 0.0811638718249786 0.471145361080517 no 1555 0.467655815398869 2225 17027303
SGTC_2015 5119600 184 µM 0.0803180711702305 0.471509402373063 no 1556 0.467992142964947 2232 2828786
SGTC_1096 rimcazole 32.2 µM 0.0799422903139119 0.47167114997088 no 1557 0.468141577317428 2169 18528119 A dopamine reuptake inhibitor.
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.0799008390911922 0.471688992134192 no 1558 0.468158061233439 2261 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2938 9059746 27.26 µM 0.0795108233806692 0.471856872323845 no 1559 0.468313161528479 2216 6471769
SGTC_1791 st048313 56.1 µM 0.0785496330165283 0.472270632892734 no 1560 0.468695425356331 2289 1204976
SGTC_105 0111-0055 734.78 µM 0.0770323287663834 0.472923842774722 no 1561 0.469298913366239 2202 5179370
SGTC_3266 9136860 49.47 µM 0.0763785398715501 0.473205325927621 no 1562 0.469558971213527 2266 4871271 YPR165W RHO1
SGTC_3082 9117008 49.47 µM 0.0761327250998276 0.473311162819755 no 1563 0.469656752410189 2150 41448529
SGTC_2320 7373003 200 µM 0.0760822555975309 0.473332892972901 no 1564 0.469676828600084 2193 5415828
SGTC_2701 st077767 14.721 µM 0.0760471863205186 0.473347992450489 no 1565 0.469690778802165 2214 5721188
SGTC_1373 2887-0003 58.5 µM 0.0757068337707047 0.473494537112465 no 1566 0.469826169518484 2204 776948
SGTC_953 1188-0045 9.7 µM 0.0751543174846386 0.473732440160707 no 1567 0.470045965438223 2207 6144426
SGTC_171 k064-0041 9.68 µM 0.0750570668727531 0.473774315404308 no 1568 0.470084653547858 2167 53325
SGTC_2596 sinensetin 100 µM 0.0748825737547476 0.47384945130627 no 1569 0.470154070876671 2205 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1789 tunicamycin 25 nM 0.0740252204865974 0.474218636986404 no 1570 0.470495158632783 2256 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1531 st059297 52.4 µM 0.073664252304462 0.47437408046949 no 1571 0.470638772002358 2235 7566702
SGTC_1145 3546-0597 10.2 µM 0.0732149411316453 0.474567572482322 no 1572 0.470817538496847 2169 875334
SGTC_1771 st048882 4.1505 µM 0.0730538689091022 0.474636938320177 no 1573 0.470881625398249 2213 4580403
SGTC_250 brefeldin a 552.239 µM 0.0708520328462835 0.475585236389503 no 1574 0.471757759810282 2267 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_274 sirtinol 40.1 µM 0.0705305302061043 0.475723714498826 no 1575 0.471885700729605 2123 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2743 auranofin 4.32 µM 0.0698096295929133 0.476034232548413 no 1576 0.472172591286219 2249 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_493 zm226600 134 µM 0.0697518403609627 0.476059125099949 no 1577 0.472195589792075 2248 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1526 st051518 75 µM 0.0696969592993565 0.476082765051668 no 1578 0.472217431012904 2103 673993
SGTC_1554 st069299 38.7 µM 0.0692955483383178 0.476255674897921 no 1579 0.472377184566618 2225 24207999
SGTC_2546 rhodinyl acetate 100 µM 0.0690980544650115 0.476340748047703 no 1580 0.472455784820473 2288 6708682
SGTC_1241 0364-0022 50.8 µM 0.0688754135640653 0.47643665491178 no 1581 0.472544394583513 2226 4563895
SGTC_346 4513-0042 7.16 µM 0.0687131487160234 0.476506554486339 no 1582 0.472608975890533 2281 2827372
SGTC_2725 haloperidol 53.21 µM 0.0685986623170367 0.476555872753838 no 1583 0.47265454183836 2279 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3148 9097893 49.47 µM 0.0683890374835045 0.476646175533925 no 1584 0.472737974110218 2218 17174100
SGTC_1207 2099-0101 141 µM 0.0658163630183163 0.477754535799028 no 1585 0.473762014339046 2294 5837381
SGTC_375 3970-0961 9.27 µM 0.0656471220836746 0.477827454347498 no 1586 0.473829386000954 2226 2898222
SGTC_1156 4092-0367 4.88 µM 0.0654574718899904 0.477909167238726 no 1587 0.473904883097781 2178 1357585
SGTC_3279 9140807 49.47 µM 0.065323080671293 0.477967071749574 no 1588 0.473958382934976 2266 45595718
SGTC_1849 st056239 19.2 µM 0.063504845619708 0.47875053132918 no 1589 0.474682250393996 2167 5393181
SGTC_2707 st078556 66.6 µM 0.0630833553682671 0.478932159162751 no 1590 0.474850064194894 2306 17250899
SGTC_2658 polymyxin b sulfate 77.05 µM 0.0625199573446899 0.479174944468384 no 1591 0.475074384682378 2251 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_2323 6148992 148.28 µM 0.0622886340039758 0.479274630958543 no 1592 0.475166489826159 2238 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.0617487942498332 0.479507274557045 no 1593 0.475381440942878 2298 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2065 5221596 34.26 µM 0.0617342912724224 0.479513524702582 no 1594 0.475387215776378 2257 788581
SGTC_1141 3253-0389 52.6 µM 0.0614311511019071 0.479644165937029 no 1595 0.475507922104435 2284 5402031
SGTC_1835 st008666 49.2 µM 0.0599444009549325 0.48028492691626 no 1596 0.476099958303093 2193 690455
SGTC_1041 0206-0046 107 µM 0.0599208993563905 0.480295056070727 no 1597 0.47610931726098 2187 50494
SGTC_277 nystatin 15.5 µM 0.0595695465380607 0.480446490132967 no 1598 0.476249236811021 2297 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1744 st037937 38.9 µM 0.0595562456962689 0.480452222889117 no 1599 0.476254533674894 2254 1016152
SGTC_3277 9138724 49.47 µM 0.0574845593400005 0.481345182856907 no 1600 0.477079602815227 2193 15943418
SGTC_2862 9027634 71.43 µM 0.0572555011810736 0.481443919734022 no 1601 0.477170833540919 2284 5012562
SGTC_2652 actinonin 100 µM 0.0565495195475575 0.481748244436099 no 1602 0.477452023856732 2323 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1020 4335-0961 93.3 µM 0.0559610771049488 0.482001910120213 no 1603 0.477686407257998 2182 669075
SGTC_3183 9108214 49.47 µM 0.0556708179766078 0.482127037673802 no 1604 0.477802023658994 2296 4974831
SGTC_1632 st005650 90 µM 0.0554711531462652 0.482213112033614 no 1605 0.477881555504224 2248 2759605
SGTC_2649 anisomycin 9.56 µM 0.0550240958851102 0.482405838847711 no 1606 0.478059633564655 2258 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_958 1222-0007 33 µM 0.0547514390153577 0.482523383507149 no 1607 0.478168244190598 2291 7312461
SGTC_1068 loratadine 26.9 µM 0.0547507104818404 0.482523697586088 no 1608 0.47816853439812 2207 3957 A H1 histamine antagonist.
SGTC_2665 lovastatin 100 µM 0.0539622239525533 0.482863629254969 no 1609 0.478482630642744 2279 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1600 coumarin 106 71.1 µM 0.0534643509196663 0.483078278302574 no 1610 0.478680966925608 2274 100336 A hepatotoxic, DNA x-linker.
SGTC_541 4513-1321 94 µM 0.0530105817758476 0.483273917021573 no 1611 0.47886173826589 2172 747515
SGTC_655 k060-0012 42 µM 0.0521642757463483 0.483638805414039 no 1612 0.479198898992223 2260 5994525
SGTC_93 0109-0045 59.227 µM 0.0519322123599324 0.483738862922751 no 1613 0.479291353573098 2307 88733
SGTC_2048 5246248 200 µM 0.0517836823866693 0.4838029043217 no 1614 0.479350528837324 2339 677046
SGTC_3105 9121040 49.47 µM 0.050816155267296 0.484220081385305 no 1615 0.479736008733609 2328 41448907
SGTC_2953 9074162 66.49 µM 0.0507917136014951 0.484230620336058 no 1616 0.479745746971997 2317 16451992
SGTC_1458 k015-0034 6.33 µM 0.0495144306029214 0.4847813844762 no 1617 0.480254668673784 2198 3598957
SGTC_3220 9131269 49.47 µM 0.0491571341399312 0.484935455872461 no 1618 0.480397035970896 2337 17722206
SGTC_2850 9015429 58.44 µM 0.0482058974451432 0.485345653778919 no 1619 0.480776075086133 2276 6457570
SGTC_2247 cerulenin 830 nM 0.04691385119259 0.48590284234986 no 1620 0.481290944297276 2308 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_3145 9085516 49.47 µM 0.0468009764671914 0.485951520341183 no 1621 0.481335925389856 2171 25236195
SGTC_1346 1488-2224 62.4 µM 0.0465769985083626 0.486048112975002 no 1622 0.481425182330402 2326 3722427
SGTC_2630 antimycin a 100 µM 0.045629119892957 0.486456903675395 no 1623 0.481802929509938 2319 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_3310 9130229 44.1445 µM 0.0450971112180544 0.486686348808683 no 1624 0.482014951997895 2309 7761258
SGTC_2286 7945697 125 µM 0.0450183652285434 0.48672031081926 no 1625 0.482046335229226 2268 1245733
SGTC_2936 9038235 15.59 µM 0.0424777424272396 0.487816095128126 no 1626 0.483058927351268 2331 4749415
SGTC_2778 tioconazole 65.09 nM 0.0412449117975125 0.488347855283132 no 1627 0.483550324838989 2314 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2991 9074669 71.4286 µM 0.041061605699367 0.488426922987901 no 1628 0.483623391492985 2316 17333109
SGTC_1782 st039423 80.636 µM 0.0407344625169225 0.488568034863844 no 1629 0.48375379363549 2270 2068169
SGTC_2897 9048598 12.99 µM 0.0407048297646169 0.488580816901504 no 1630 0.483765605596564 2308 6467404
SGTC_2424 5537928 59.2 µM 0.0398362312305684 0.488955490567732 no 1631 0.484111845400509 2301 5382802
SGTC_1611 st001856 99.4 µM 0.0393567233006658 0.48916233254629 no 1632 0.4843029914798 2309 647478
SGTC_3271 9137798 49.47 µM 0.0392184362764446 0.489221984995718 no 1633 0.484358117460269 2324 6498326
SGTC_3011 9081274 71.4286 µM 0.0391933920504678 0.489232788272475 no 1634 0.484368100985085 2297 6625322
SGTC_861 0443-0273 110 µM 0.0380878569266338 0.489709688465007 no 1635 0.484808816527464 2266 6149169
SGTC_503 tyrphostin 8 294 µM 0.0378810014629522 0.489798922391033 no 1636 0.484891280406111 2329 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_86 0417-1630 471.922 µM 0.0376382713257721 0.489903632691337 no 1637 0.484988046711505 2335 3634867
SGTC_2819 7996655 46.38 µM 0.0372226157942189 0.490082942138983 no 1638 0.485153753154744 2326 6456960
SGTC_825 1988-2224 89.6 µM 0.0365154672843184 0.490388003193808 no 1639 0.485435672912406 2321 1180859
SGTC_1283 0922-0125 16.4 µM 0.0363199542457521 0.490472347740862 no 1640 0.485513619624194 2327 3360884
SGTC_1182 1222-0449 220 µM 0.0362921176346507 0.490484356521265 no 1641 0.485524717508677 2303 658318
SGTC_950 1165-0508 94.1 µM 0.0356277290001373 0.490770977897434 no 1642 0.48578959890416 2297 6148369
SGTC_2276 7947513 42.08 µM 0.0355989537296282 0.490783391836276 no 1643 0.485801071298612 2177 2105100
SGTC_216 k038-0035 28.382 µM 0.0349193990041585 0.491076561094558 no 1644 0.486072005938622 2329 4444231 YPR107C YTH1
SGTC_398 bronopol 33.3 µM 0.0346097311392152 0.491210157680482 no 1645 0.486195470911451 2285 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1252 0493-0875 34.8 µM 0.0342599184732859 0.491361074679689 no 1646 0.486334943258715 2338 3960963
SGTC_17 0960-0276 49.807 µM 0.033939132795264 0.491499469875354 no 1647 0.486462843846484 2342 6821114
SGTC_948 3448-0295 75.3 µM 0.0338491533300348 0.491538289516414 no 1648 0.486498719846194 2353 678569
SGTC_3131 9127911 49.47 µM 0.0334734502314208 0.491700379132472 no 1649 0.486648518804839 2305 45595681
SGTC_1513 0337-0559 19 µM 0.0318943265621934 0.492381675249192 no 1650 0.487278161543565 2307 775073
SGTC_3317 9138495 8.753 µM 0.0301780518498681 0.493122168863581 no 1651 0.487962526322267 2344 17020139
SGTC_2811 7967822 32.47 µM 0.0290818634624694 0.493595136308076 no 1652 0.488399650270214 2340 2232244
SGTC_2175 5807670 165.306 µM 0.028815252572166 0.493710171089427 no 1653 0.488505968068954 2348 241186
SGTC_1545 lovastatin 49.4 µM 0.0287863452012842 0.493722643803916 no 1654 0.488517495659434 2338 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_806 3966-4455 5.86 µM 0.0286163354021871 0.493795998356673 no 1655 0.488585291826423 2246 714982
SGTC_397 arbidol 50 µM 0.0278692326591303 0.494118355097049 no 1656 0.488883223844349 2352 131410 A RNA synthesis inhibitor.
SGTC_2038 4100038 30.985 µM 0.0260936865008068 0.494884475287432 no 1657 0.489591306396064 2334 3596803
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.0259809012191219 0.494933141026458 no 1658 0.489636285964188 2295 689007
SGTC_419 nsc-638432 893 µM 0.0254177197341806 0.49517614940838 no 1659 0.48986088868491 2316 368090
SGTC_1968 st069590 43.6 µM 0.0246915014029544 0.495489509536863 no 1660 0.490150516956722 2355 6384066
SGTC_403 arphamenine a 50 µM 0.0240057966272131 0.495785390795918 no 1661 0.490423992500361 2369 5487158 An arginine aminopeptidase inhibitor.
SGTC_2597 laccaic acid a 100 µM 0.0235259597463696 0.49599244155247 no 1662 0.490615365664953 2331 5491415 A textile dye.
SGTC_2047 4141938 200 µM 0.0234280134359068 0.49603470575313 no 1663 0.490654429822432 2340 3807862
SGTC_305 1682-2595 20.8 µM 0.0225694646323753 0.496405174637239 no 1664 0.490996850657079 2333 226033
SGTC_2408 sulbentine 18.36 µM 0.0222207259725726 0.496555658334001 no 1665 0.491135942368157 2264 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_3343 9148379 18.9835 µM 0.0221141862665725 0.496601631221688 no 1666 0.491178435119733 2373 1955036
SGTC_2381 9035592 200 µM 0.0220116585090102 0.496645872958418 no 1667 0.491219327823187 2276 4749657
SGTC_1352 1496-0991 99 µM 0.0213623483480443 0.496926057620464 no 1668 0.491478304186108 2357 3000039
SGTC_925 2064-1272 59.6 µM 0.0204608932965914 0.497315048132451 no 1669 0.491837854084401 2340 6815817
SGTC_3099 9120367 49.47 µM 0.019131402704308 0.497888746542225 no 1670 0.492368140137601 2367 24824940
SGTC_1583 clindamycin 39.6 µM 0.0183537275356496 0.498224329059412 no 1671 0.492678333147315 2345 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_633 0437-0093 97.7 µM 0.0176314483552918 0.498536008221027 no 1672 0.492966434206636 2377 2831118
SGTC_1086 cerivastatin 2.18 µM 0.0172538332893921 0.498698957695382 no 1673 0.493117057906194 2378 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3208 9114115 49.47 µM 0.0166975736600255 0.498938996742415 no 1674 0.49333894141548 2340 650895
SGTC_1518 st038567 90.8 µM 0.0164160340190849 0.499060487837613 no 1675 0.493451244087794 2380 77966
SGTC_1356 1502-0781 85.8 µM 0.0163761160526605 0.499077713403085 no 1676 0.493467166911927 2378 567702
SGTC_2846 9008642 19.48 µM 0.0149821638782951 0.499679238243972 no 1677 0.494023204974998 2335 2992898
SGTC_424 splitomicin 100 mM 0.0144745319475596 0.499898294230853 no 1678 0.494225698848771 2305 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3003 9075612 71.4286 µM 0.0140031539280135 0.499898294230853 no 1679 0.494413732406714 2357 6501993
SGTC_709 3807-1509 243 µM 0.0139218516131192 0.499863210226744 no 1680 0.494446164176146 2382 1886677 YPL242C IQG1
SGTC_3068 9116768 49.47 µM 0.0137289545505926 0.49977997027277 no 1681 0.494523111615747 2360 41904888
SGTC_1729 st035615 45.989 µM 0.0131690812165135 0.499538370857131 no 1682 0.494746448558395 2251 17385451
SGTC_1938 st074717 56.4 µM 0.0130899445803751 0.49950422142121 no 1683 0.494778016787424 2390 17250979
SGTC_2997 9067075 71.4286 µM 0.0127257002192142 0.499347040928525 no 1684 0.494923317157797 2359 27209819
SGTC_2053 5265679 138 µM 0.012159671574099 0.499102785713402 no 1685 0.4951491124337 2385 764595
SGTC_2228 7354201 200 µM 0.011777260429438 0.498937766128921 no 1686 0.4953016614806 2348 753451
SGTC_1223 0764-0573 147 µM 0.0116496773556485 0.498882711010395 no 1687 0.495352556271325 2381 1609797
SGTC_3155 9099265 49.47 µM 0.0116394714112989 0.498878306904555 no 1688 0.495356627578002 2379 25236499
SGTC_878 0828-0289 13.7 µM 0.0112887907775813 0.498726980021965 no 1689 0.495496519715938 2383 745350 YLR208W SEC13
SGTC_1963 st076565 50.3 µM 0.0103434615329224 0.498319049351151 no 1690 0.495873629447079 2382 4914280
SGTC_2874 9043904 71.43 µM 0.00946793156109757 0.497941240182965 no 1691 0.496222898223404 2353 4463428
SGTC_1424 4048-1941 275 µM 0.0090363591238911 0.497755008469177 no 1692 0.496395063345311 2388 X1424
SGTC_1371 2421-0008 32.7 µM 0.00901629839873623 0.497746351896367 no 1693 0.496403066090734 2381 2827552
SGTC_2968 9090663 33.37 µM 0.00889350298701556 0.497693363435226 no 1694 0.496452052408126 2355 25236811
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.00875067936592838 0.497631732487488 no 1695 0.496509028571919 2395 1273210
SGTC_1945 st075991 56.6 µM 0.0087290749887341 0.497622409817093 no 1696 0.496517647142251 2373 1084980
SGTC_1065 prochlorperazine maleate 2.48 µM 0.00817577306533369 0.497383650719883 no 1697 0.496738374785592 2390 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1030 k029-0042 36.7 µM 0.00763431822650527 0.497150004745831 no 1698 0.496954377262014 2340 6080581
SGTC_887 0885-0007 9.62 µM 0.00654931260977564 0.496681811391161 no 1699 0.497387220970945 2384 5719458
SGTC_2518 prenyletin 46.28 µM 0.00556609793839975 0.496257546019327 no 1700 0.497779459661448 2393 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_115 0527-0192 112.043 µM 0.00552499868586785 0.496239811436202 no 1701 0.497795855638859 2379 4233931
SGTC_3351 9150312 21.596 µM 0.0053480084618583 0.496163439138925 no 1702 0.497866463478907 2396 4904905
SGTC_3050 9093513 49.47 µM 0.00520763482361116 0.496102867208368 no 1703 0.497922463678252 2398 25236664
SGTC_3355 9151058 44.0485 µM 0.00514110181862905 0.496074157913557 no 1704 0.497949006151649 2399 17015728
SGTC_2046 4110841 106 µM 0.00505493874948988 0.496036978186854 no 1705 0.497983379796242 2396 44119630 YMR134W ERG29
SGTC_1064 honokiol 6.76 µM 0.00473530279632811 0.495899054232051 no 1706 0.498110894563975 2388 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_909 3448-9333 149 µM 0.0041448912677657 0.495644291035812 no 1707 0.498346432360372 2395 3344074
SGTC_658 3253-0951 102 µM 0.00358343411129849 0.495402023327916 no 1708 0.498570419683511 2400 1184878
SGTC_660 4031-1742 102 µM 0.00336703964876184 0.495308649971848 no 1709 0.498656748062386 2401 6738706
SGTC_3316 9136639 10.545 µM 0.00293877336020044 0.49512385552211 no 1710 0.498827600741648 2374 4903665
SGTC_1981 st071826 47 µM 0.00177614216479232 0.494622192212884 no 1711 0.499291422167017 2387 11838600
SGTC_3188 9110789 49.47 µM 0.00174835948315601 0.494610204374633 no 1712 0.499302505836174 2402 849217
SGTC_2335 9018011 154.17 µM 0.00138109069462782 0.494451733494652 no 1713 0.499449024704 2401 6458208
SGTC_606 k015-0008 38.6 µM 0.000472175731727222 0.494059554370164 no 1714 0.499811629143834 2405 1970475
SGTC_3036 9090181 49.47 µM 0.000370223027662388 0.49401556411288 no 1715 0.499852302384461 2402 25236586
SGTC_457 grayanotoxin iii 135 µM 5.5490207044091e-06 0.493858216228668 no 1716 0.499997786261026 2404 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2759 disulfiram 3.38 µM -7.78962364167446e-05 0.493822211781584 no 1717 0.499968923897841 2407 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_963 1269-2853 151 µM -0.000694743549992717 0.493556059871376 no 1718 0.499722837446168 2408 3668223
SGTC_2835 9006588 71.43 µM -0.0017022028677286 0.49312137631541 no 1719 0.499320919634181 2414 2345538
SGTC_3085 9117376 49.47 µM -0.00183546015599125 0.49306388104392 no 1720 0.499267757750926 2411 16480349
SGTC_2347 9049783 174.81 µM -0.00200551085052424 0.492990511076175 no 1721 0.499199917464254 2410 6467988 YPL169C MEX67
SGTC_1478 0453-0656 35.7 µM -0.002718550056238 0.492682866230963 no 1722 0.498915456777068 2411 5258496
SGTC_2282 7944268 200 µM -0.00437904210555165 0.491966454618133 no 1723 0.498253020539788 2410 2970414
SGTC_1705 st027868 56.3335 µM -0.00491480563219363 0.491735307341096 no 1724 0.498039284126984 2423 292948
SGTC_2555 cholic acid 100 µM -0.0050531748327674 0.491675610436726 no 1725 0.497984083488214 2443 6708657 Influences liver metabolism.
SGTC_1962 st076595 64.5 µM -0.00633918749102425 0.491120792487611 no 1726 0.497471047024238 2417 279619
SGTC_2413 inermin 26.06 µM -0.0069397984079636 0.490861679771365 no 1727 0.497231443220271 2422 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2683 piperine 63.03 µM -0.00715433737745377 0.490769125314652 no 1728 0.497145856679902 2421 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2343 7990716 14.84 µM -0.00787654073403713 0.490457562573239 no 1729 0.496857747368759 2423 6456862
SGTC_82 0054-0107 293.755 µM -0.00818226192706199 0.490325674409949 no 1730 0.496735786190882 2452 3104697
SGTC_2357 9067248 200 µM -0.0088119155129453 0.490054045117998 no 1731 0.496484599825672 2422 9150235
SGTC_2304 7443016 91.4 µM -0.00898569402510861 0.489979078775811 no 1732 0.49641527497476 2412 939854
SGTC_2853 9015042 58.44 µM -0.00927359277451565 0.489854882865204 no 1733 0.496300424778047 2422 6457456
SGTC_2889 9059656 51.95 µM -0.00950745348768946 0.489753999009329 no 1734 0.49620713196551 2426 3949838
SGTC_3104 9120930 49.47 µM -0.0106032213798903 0.489281310706731 no 1735 0.495770005945097 2442 17014836
SGTC_3058 9093861 49.47 µM -0.0154508525984301 0.487190347176488 no 1736 0.49383624687549 2441 17217477
SGTC_3001 9076041 71.4286 µM -0.0154520632473691 0.487189825020185 no 1737 0.493835763954093 2436 16004211
SGTC_2841 9004761 38.96 µM -0.0161026143696981 0.486909243685531 no 1738 0.493576263910368 2437 2991039
SGTC_844 0330-0132 15.3 µM -0.0162037014316708 0.486865645625874 no 1739 0.493535941268289 2429 2828079
SGTC_1743 st037606 46.3785 µM -0.0167868454706081 0.486614143241062 no 1740 0.493303332106825 2454 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1667 st014849 34.6 µM -0.0170729216784358 0.486490764260527 no 1741 0.493189220567046 2433 5348460
SGTC_1946 st076057 65.1 µM -0.0173718932474703 0.486361825149096 no 1742 0.493069965855424 2455 953009
SGTC_2655 perillic acid 100 µM -0.0175353845584447 0.486291315955169 no 1743 0.49300475219283 2441 5702197 An apoptosis inducer.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.0180009834358553 0.48609051863916 no 1744 0.49281903443524 2441 5106787 A p450 inhibitor.
SGTC_107 0358-0022 2.6945 µM -0.0182821703574194 0.485969253773292 no 1745 0.492706875542108 2487 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_364 0083-0097 67.7 µM -0.0198099733241221 0.485310395376817 no 1746 0.492097480941665 2475 5207356
SGTC_3284 9108171 64.8615 µM -0.0204748369117529 0.485023688257705 no 1747 0.49183229255185 2465 8687505
SGTC_42 0133-0086 60.653 µM -0.0241928947999386 0.483420508255033 no 1748 0.490349372800688 2457 162923 Model of phenazepam hydroxylation.
SGTC_1885 st057546 99.9 µM -0.0252401794487504 0.482968979487411 no 1749 0.489931694294635 2505 702008
SGTC_1466 k213-0079 57.5 µM -0.0256983833017636 0.482771435234734 no 1750 0.489748956685345 2445 3657981
SGTC_898 1000-0849 28.3 µM -0.0261917332361265 0.482558743272044 no 1751 0.489552204772021 2442 6751807
SGTC_2025 5147754 141 µM -0.0273088921547288 0.482077134561818 no 1752 0.489106682300456 2471 315777 YLR208W SEC13
SGTC_726 3448-4391 34.2 µM -0.0276717374081561 0.48192071707856 no 1753 0.488961982674758 2487 1356692
SGTC_1806 st050005 60.3 µM -0.0282163867788901 0.481685931630033 no 1754 0.488744783834114 2465 5194765
SGTC_3252 9135871 49.47 µM -0.0292142106358686 0.481255809926751 no 1755 0.488346873811507 2506 17682838
SGTC_1780 st038448 24.544 µM -0.0292542082182103 0.481238569030381 no 1756 0.488330923901962 2564 728868 YDL195W SEC31
SGTC_365 0121-0052 13.6 µM -0.0308054250938641 0.480569946765328 no 1757 0.487712356937787 2480 3101739
SGTC_1302 1159-0335 255 µM -0.032353513282628 0.479902727553926 no 1758 0.487095067044009 2464 649284
SGTC_2331 7980721 200 µM -0.0325265388300865 0.479828157766687 no 1759 0.487026076148643 2508 2981221
SGTC_1143 3454-2408 5.08 µM -0.0330109207060717 0.479619404765232 no 1760 0.486832939462268 2448 X1143
SGTC_3124 9127567 49.47 µM -0.0332520203400328 0.479515500661503 no 1761 0.486736807401016 2468 17592030
SGTC_2453 5731132 22.18 µM -0.0343279425753954 0.479051839148176 no 1762 0.486307821521573 2483 1362040
SGTC_3333 9141820 12.094 µM -0.0360749202216294 0.478299051437046 no 1763 0.485611310035692 2502 1939433
SGTC_1919 st067113 52.3 µM -0.0371524993099485 0.477834751760227 no 1764 0.485181706249813 2514 1268243
SGTC_1648 st011736 69.8 µM -0.0375860458713445 0.47764795672696 no 1765 0.485008866921267 2490 2855514
SGTC_749 1000-0129 128 µM -0.0378886476758869 0.477517582601758 no 1766 0.484888232196757 2502 708470
SGTC_341 1486-1430 230 µM -0.0383302007354695 0.477327346504378 no 1767 0.48471220588409 2485 2054753 YPL210C SRP72
SGTC_1876 myriocin 605 nM -0.0402539869371907 0.476498574739433 no 1768 0.483945318563126 2496 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1924 st058459 75.1 µM -0.0418663769199019 0.475804031371974 no 1769 0.483302610107985 2481 688683
SGTC_2999 9069765 71.4286 µM -0.0430836641244507 0.475279728673235 no 1770 0.482817420673859 2510 2097066
SGTC_159 3970-0959 50 µM -0.0433090382938545 0.475182661521559 no 1771 0.482727593233692 2525 6615653
SGTC_946 3434-1334 87.4 µM -0.0443160996351217 0.474748944995449 no 1772 0.482326219314458 2533 4047976
SGTC_1291 0993-0025 5.79 µM -0.0445840387574366 0.474633555230668 no 1773 0.482219432617479 2520 4353356
SGTC_449 xestospongin c 11.1929 µM -0.0447775865752483 0.474550203898988 no 1774 0.482142295245797 2531 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_3201 9113999 49.47 µM -0.0463112231530052 0.473889783273199 no 1775 0.481531097062834 2569 16649224
SGTC_1428 4049-0204 61.7 µM -0.0464938438183946 0.473811147187938 no 1776 0.481458320351657 2514 X1428
SGTC_1429 4049-0205 9.46 µM -0.0469613741921441 0.473609834222091 no 1777 0.481272006236553 2491 22774478
SGTC_2097 5376186 200 µM -0.048023292586155 0.473152610029332 no 1778 0.480848839610669 2496 742755
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.0494597507555923 0.472534178758158 no 1779 0.480276456082049 2526 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2960 9079389 5.97 µM -0.0513704317188336 0.4717116855289 no 1780 0.479515172861827 2513 16457355
SGTC_2539 epi(13)torulosol 80 µM -0.0526839147627856 0.471146338590428 no 1781 0.478991877692736 2557 6708597
SGTC_490 phenamil 164 µM -0.0534686300722429 0.470808610551596 no 1782 0.478679262229042 2529 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_518 1021-0119 62.6 µM -0.0543147571688818 0.470444475460442 no 1783 0.478342196194118 2537 1097762
SGTC_1555 citronellol 128 µM -0.05431528895936 0.470444246609449 no 1784 0.478341984353121 2502 8842 A terpine precursor.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.0545305232539934 0.470351623372681 no 1785 0.478256245360164 2499 1241132 A phosphatase inhibitor.
SGTC_2362 9071156 126 µM -0.054755092070911 0.470254984857473 no 1786 0.47816678901517 2545 653133
SGTC_3056 9094900 49.47 µM -0.0552145943750486 0.47005725307271 no 1787 0.477983751021357 2536 25236784
SGTC_1212 0520-0165 585 µM -0.055491833374832 0.469937955906574 no 1788 0.477873317974807 2621 5403258
SGTC_747 3448-8087 38.7 µM -0.0558114499038806 0.469800426851636 no 1789 0.477746006729283 2535 5168703
SGTC_2366 9070441 60.58 µM -0.0564090691997762 0.469543284569878 no 1790 0.477507966142073 2529 6837235
SGTC_1230 0170-0365 3.77 µM -0.0579584216243638 0.468876692122652 no 1791 0.476890873779607 2575 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_38 0929-0051 58.268 µM -0.059543813113708 0.468194684568251 no 1792 0.476259484771141 2555 1379719
SGTC_2172 5754775 163.918 µM -0.0597207679117104 0.468118567477836 no 1793 0.476189015426892 2528 2263357
SGTC_2246 7293507 91.5585 µM -0.05994844004149 0.468020636046618 no 1794 0.476098349833366 2574 887656
SGTC_1908 st060353 56.5 µM -0.0600001076774603 0.467998411876058 no 1795 0.476077774466055 2548 4227716
SGTC_644 1498-1197 63.3 µM -0.0602503410634099 0.467890778608866 no 1796 0.475978126068174 2564 6741615
SGTC_2300 7976697 71.57 µM -0.0605625155675749 0.467756505805915 no 1797 0.475853813471518 2529 2236109
SGTC_122 0236-0016 402.397 µM -0.061333111268948 0.467425072165613 no 1798 0.475546960725437 2510 6808838
SGTC_1231 0242-0792 125 µM -0.0623260725953255 0.466998032275213 no 1799 0.475151582953032 2499 3707635
SGTC_1170 0310-0127 64.8 µM -0.0634849242757149 0.46649969648696 no 1800 0.474690181856029 2575 774975
SGTC_3242 9133940 49.47 µM -0.063620148914154 0.466441549848938 no 1801 0.474636343864103 2656 17248444
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.0647563081099144 0.465953029441011 no 1802 0.474184014735505 2522 688669
SGTC_2444 5485484 36.41 µM -0.0651638602168779 0.465777804558 no 1803 0.474021767657211 2583 6790631
SGTC_771 0250-0039 27.3 µM -0.0656375934766963 0.465574133776821 no 1804 0.473833179184082 2517 3005115
SGTC_1456 k015-0012 13 µM -0.0663254140018528 0.465278437136347 no 1805 0.47355937516078 2526 2989616
SGTC_1295 1013-0063 9.78 µM -0.0676817291782789 0.464695408449325 no 1806 0.473019496979616 2539 6826038
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0677107479946432 0.464682935179445 no 1807 0.473007946643516 2687 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1093 fluphenazine 7.97 µM -0.0689519587594611 0.464149453412046 no 1808 0.472513929894539 2539 6602611 An atypical antipsychotic.
SGTC_2816 7982706 58.44 µM -0.0691845251369347 0.464049501765698 no 1809 0.472421370371274 2609 2981853
SGTC_2239 6685329 187.64 µM -0.0697869783657641 0.463790591878397 no 1810 0.472181605833116 2673 805680
SGTC_2586 curcumin 80 µM -0.0700412345523251 0.4636813275088 no 1811 0.472080419890505 2599 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1521 st012942 49.4 µM -0.0720850605136503 0.462803111415809 no 1812 0.471267107638408 2745 24207259
SGTC_1852 st056254 31.4 µM -0.0748856118700248 0.461600031534227 no 1813 0.470152862237588 2596 442583
SGTC_1217 1183-1422 255 µM -0.0752050886322366 0.461462810653215 no 1814 0.47002576783984 2610 2849664
SGTC_1638 st008370 60.6 µM -0.0759187122215664 0.461156313379924 no 1815 0.469741884811063 2526 24207134
SGTC_408 cantharidin 100 µM -0.0759729579698173 0.461133016080799 no 1816 0.469720306208582 2592 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2667 digitoxin 100 µM -0.0764985290027106 0.460907302349494 no 1817 0.469511242116788 2563 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_630 4356-0227 183 µM -0.076780148423306 0.460786362181308 no 1818 0.469399221687785 2539 779312
SGTC_2173 5763948 167 µM -0.0774297184295517 0.46050742117182 no 1819 0.469140849927511 2544 2867177
SGTC_61 0978-8327 98.565 µM -0.0776571952676758 0.460409741724642 no 1820 0.469050372229134 2552 6150059 YHR072W ERG7
SGTC_1863 st057641 20.1 µM -0.0777842810565623 0.460355171627868 no 1821 0.468999825230423 2535 3921635
SGTC_453 enantio-paf c16 10 µM -0.0784371818108659 0.460074830617358 no 1822 0.468740148908583 2559 13871343 A lipid and platelet activating factor
SGTC_1016 4226-1401 38 µM -0.0803013685163346 0.459274500157454 no 1823 0.467998784906106 2541 2901613
SGTC_715 0868-0130 184 µM -0.0807143182982913 0.459097235251611 no 1824 0.467834574807735 2600 2876258
SGTC_2909 7941780 10.49 µM -0.0811153024866613 0.458925114538713 no 1825 0.467675128082894 2547 1243215
SGTC_1463 k081-0032 34.1 µM -0.0814356372242592 0.458787617781651 no 1826 0.467547754404522 2546 977755
SGTC_218 alverine citrate 93.75 µM -0.0818739614983218 0.458599484560298 no 1827 0.467373470310174 2645 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3177 9107506 49.47 µM -0.0821026765675728 0.458501321413341 no 1828 0.467282532359595 2579 8897194
SGTC_1861 st057647 17.4 µM -0.0822256018264058 0.458448563668825 no 1829 0.467233657530956 2712 688668
SGTC_911 3456-4043 236 µM -0.0823004130614832 0.458416456126161 no 1830 0.4672039129804 2608 914281
SGTC_2810 7959871 45.46 µM -0.0827885249641768 0.458206974558594 no 1831 0.467009846777945 2620 2974535
SGTC_2786 7743617 45.45 µM -0.0834628807106713 0.457917582369544 no 1832 0.466741745639333 2592 583674
SGTC_2007 4011539 71.82 µM -0.085864118449308 0.456887300376331 no 1833 0.465787217730442 2555 45595301
SGTC_63 0099-0242 26.702 µM -0.0865088805045206 0.456610705963098 no 1834 0.465530948458464 2558 3898502 YLR359W ADE13
SGTC_3198 9112019 49.47 µM -0.0868889541134746 0.456447669239865 no 1835 0.465379889826678 2569 45595555
SGTC_3180 9109287 49.47 µM -0.0877993170255123 0.456057188995281 no 1836 0.465018090302443 2649 18891271
SGTC_535 2293-4129 48.2 µM -0.0885297985926438 0.455743895586013 no 1837 0.464727800730782 2550 396118 YIL048W NEO1
SGTC_143 4032-1194 15.74 µM -0.0891568271099163 0.45547499369428 no 1838 0.464478637829364 2529 1806963
SGTC_246 cycloheximide 667 µM -0.0893456823537181 0.45539400689972 no 1839 0.464403594971548 2563 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_759 3486-0358 89.3 µM -0.0897900174582896 0.455203469993008 no 1840 0.464227040530522 2558 875103
SGTC_2201 6605497 169.863 µM -0.0902524621191194 0.455005178407047 no 1841 0.464043297824225 2612 670741
SGTC_1091 telmisartan 47.6 µM -0.090516939298125 0.454891778307798 no 1842 0.463938216797604 2663 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1152 3909-8331 15.9 µM -0.0912706132591215 0.454568645092817 no 1843 0.463638783863567 2580 16001939
SGTC_930 2810-3379 265 µM -0.0923578849307984 0.454102536872088 no 1844 0.463206849658471 2672 1015764
SGTC_2014 4013930 200 µM -0.0932951612742118 0.453700781640241 no 1845 0.462834538031253 2556 64556
SGTC_2067 5224629 34.075 µM -0.0935565767843074 0.453588736620925 no 1846 0.46273070248084 2665 2835000
SGTC_2885 9057732 51.95 µM -0.0946650104972737 0.453113693190153 no 1847 0.462290455352868 2676 6471414
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.0963027055366206 0.452411946263569 no 1848 0.461640081184504 2867 5282309
SGTC_1267 0828-0272 9.49 µM -0.0972601833545963 0.45200173888208 no 1849 0.461259887560752 2654 745334
SGTC_1417 3966-0327 90.4 µM -0.0975180715422515 0.451891261889717 no 1850 0.46115749180615 2602 651118
SGTC_1827 berberine 7.24 µM -0.0977804232812599 0.451778876574526 no 1851 0.461053326419228 2590 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2131 toluylene red 5.2905 µM -0.0980434353636752 0.451666212262661 no 1852 0.460948901528616 2606 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1409 3909-8004 61.9 µM -0.0988500507948313 0.451320713391878 no 1853 0.460628664135992 2619 2119279
SGTC_1742 st038235 28.8875 µM -0.099585087506616 0.451005906050741 no 1854 0.460336866706338 2689 564103 YBR002C RER2
SGTC_2041 5107442 45.335 µM -0.100435180860113 0.450641859780598 no 1855 0.459999420336125 2615 793005
SGTC_2470 5664817 21.68 µM -0.100940240362877 0.450425591379536 no 1856 0.459798949516458 2582 2859561
SGTC_1621 st003705 32.4 µM -0.101798344666931 0.450058181633931 no 1857 0.459458369795157 2618 24207032
SGTC_636 0kpi-0074 126 µM -0.101905308183063 0.450012386654091 no 1858 0.459415918289773 2641 616434
SGTC_1229 0139-0193 12.2 µM -0.102433033249775 0.449786458073527 no 1859 0.459206482410562 2611 3090752
SGTC_776 4476-4378 112 µM -0.102504012096823 0.449756071994223 no 1860 0.4591783142165 2678 2892008
SGTC_1956 st077085 54 µM -0.102607108121577 0.44971193706011 no 1861 0.459137400577555 2623 24208685
SGTC_2918 7977171 22.06 µM -0.102620365766993 0.449706261568202 no 1862 0.459132139314746 2574 2236483
SGTC_1396 3511-0007 98.6 µM -0.102687551095284 0.449677500225 no 1863 0.459105477098436 2683 X1396
SGTC_65 0798-0905 34.986 µM -0.103273014824101 0.449426880471523 no 1864 0.458873146066753 2813 3602145
SGTC_1859 st055998 20 µM -0.103348829240325 0.449394428029351 no 1865 0.458843061468481 2589 676301
SGTC_2102 5377816 72.7585 µM -0.103784275641484 0.449208041292251 no 1866 0.45867027264799 2701 1379702
SGTC_3053 9095903 49.47 µM -0.105723195430706 0.448378250435382 no 1867 0.457900988098337 2591 17174018
SGTC_1663 st014140 55.4 µM -0.106187814146144 0.44817944303574 no 1868 0.457716669591632 2602 4207120
SGTC_324 1315-0088 19.6 µM -0.106380036944927 0.448097195923287 no 1869 0.457640415701031 2581 6787421
SGTC_613 3914-0030 117 µM -0.107535283165316 0.447602943375458 no 1870 0.457182167839842 2549 1145395
SGTC_2766 oltipraz 83.91 µM -0.107539832762809 0.447600997067465 no 1871 0.457180363277541 2660 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_196 k015-0023 18.111 µM -0.109773303730308 0.446645676259285 no 1872 0.456294581802039 2604 5211998
SGTC_2568 diosmetin 100 µM -0.111429203434048 0.445937599075841 no 1873 0.455638001632396 2590 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2914 7968218 45.32 µM -0.111796592812144 0.445780523453926 no 1874 0.455492344565333 2683 2977111
SGTC_169 k015-0017 16.025 µM -0.113428288805129 0.445083002573836 no 1875 0.454845506604811 2662 1840002
SGTC_539 4859-0462 2.54 µM -0.115364280674569 0.444255621309869 no 1876 0.454078194890611 2761 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1166 k206-0078 225 µM -0.116393270136876 0.443815962604509 no 1877 0.453670434398439 2594 5404595
SGTC_616 4092-0450 108 µM -0.116760542441536 0.443659054033675 no 1878 0.453524906192774 2664 787165
SGTC_2284 7945075 39.21 µM -0.118728729985347 0.442818342664595 no 1879 0.452745137149344 2722 1245402
SGTC_1492 4158-0558 28.5 µM -0.120206890451026 0.442187115413102 no 1880 0.452159629783553 2727 3967268
SGTC_1625 st003711 30.1 µM -0.120287299915584 0.442152781897672 no 1881 0.452127782131123 2732 24207034 YER133W GLC7
SGTC_1368 1852-0141 284 µM -0.122220486170196 0.441327474637217 no 1882 0.451362201232825 2724 2838987
SGTC_2588 indole-3-carbinol 100 µM -0.122388995824651 0.441255547263618 no 1883 0.451295476527074 2723 3712 Induces cell cycle arrest.
SGTC_2717 st081029 62.2815 µM -0.123726413196613 0.440684747280316 no 1884 0.450765948818714 2639 5292846
SGTC_1902 st060212 70.5 µM -0.123872340877066 0.440622473844857 no 1885 0.450708176515212 2612 688944
SGTC_400 oxethazaine 37.5 µM -0.124123374583436 0.440515350715399 no 1886 0.450608795515233 2690 4621 A local anesthetic.
SGTC_262 fenpropimorph 62.5 µM -0.124256871563842 0.440458385578943 no 1887 0.45055594704684 2633 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1269 0831-0796 3.05 µM -0.124827058743751 0.440215092159952 no 1888 0.450330232576339 2705 927758
SGTC_2900 5328528 85.29 µM -0.124926056111251 0.440172853226626 no 1889 0.450291045083017 2613 795359
SGTC_1036 k216-0215 33.5 µM -0.125106918552373 0.440095686907006 no 1890 0.450219453060319 2614 622330
SGTC_1427 4048-4900 550 nM -0.125344062504441 0.439994511105919 no 1891 0.450125585195289 2729 24132586
SGTC_2927 9011802 47.9 µM -0.125849004883356 0.439779094049704 no 1892 0.449925724913112 2721 43912568
SGTC_1662 st014054 52 µM -0.126987303511916 0.439293541874104 no 1893 0.449475223761055 2605 2838777
SGTC_491 tetrandrine 80.3 µM -0.127896407336579 0.438905820490568 no 1894 0.449115477113873 2723 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1933 st074711 15.9 µM -0.129699727217994 0.438136900972359 no 1895 0.448401999196905 2602 17250958
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.130024553642887 0.437998422614333 no 1896 0.448273500297787 2737 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3304 9125678 46.087 µM -0.130249071867119 0.43790271157736 no 1897 0.448184685742223 2672 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_287 k060-0039 29.6 µM -0.130419283472714 0.437830153610844 no 1898 0.448117355441532 2746 5861974
SGTC_54 0159-0055 9 µM -0.131070487266445 0.437552577150145 no 1899 0.447859773734836 2706 3319099
SGTC_918 glabranin 770.725 nM -0.1318412078536 0.437224096219394 no 1900 0.44755494593476 2690 124049 Also referred to as licorice root.
SGTC_482 fipronil 114 µM -0.131934268114765 0.437184436881387 no 1901 0.447518141750863 2628 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_627 1391-0720 175 µM -0.131977922595252 0.437165832940914 no 1902 0.447500877098697 2724 997839
SGTC_1612 st002233 45.4 µM -0.132383275192732 0.436993093152386 no 1903 0.447340571352721 2641 1035021
SGTC_405 ebelactone b 50 µM -0.134242543533637 0.436200925946488 no 1904 0.446605392737474 2656 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1100 amiodarone 5.07 µM -0.134463623060637 0.436106748888458 no 1905 0.446517987205394 2687 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_504 lovastatin 124 µM -0.134685657846945 0.436012168548064 no 1906 0.446430206619173 2651 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2488 5268135 45.7 µM -0.13550214584929 0.435664399991246 no 1907 0.446107433881623 2765 1270356 YLR208W SEC13
SGTC_1384 3089-0840 101 µM -0.136278037558307 0.435333968795862 no 1908 0.445800742692144 2684 1069836
SGTC_2681 menadione 3.18 µM -0.137513807421399 0.434807781299415 no 1909 0.445312339839344 2700 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2563 tomatine 8.54 µM -0.139269187731983 0.434060543742669 no 1910 0.444618718597028 2615 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1702 st027038 51 µM -0.139665605839652 0.433891827351871 no 1911 0.444462101279063 2716 5521182
SGTC_2114 5491910 81.25 µM -0.139993807439723 0.433752153163483 no 1912 0.444332441576872 2759 2849228
SGTC_1239 0337-0584 35.4 µM -0.140823960377402 0.43339889831431 no 1913 0.444004507023069 2792 914301 YML130C ERO1
SGTC_3263 9137018 49.47 µM -0.141462186901901 0.43312735003975 no 1914 0.443752415038019 2679 43844957
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.141653689501742 0.433045876969814 no 1915 0.443676778193556 2663 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2504 purpurogallin 52.29 µM -0.142245955560922 0.432793920692544 no 1916 0.44344286676468 2675 5281571 An antioxidant.
SGTC_874 0599-0792 117 µM -0.142784650183642 0.432564777996348 no 1917 0.443230130118706 2647 765305
SGTC_2235 salicylic acid 500 µM -0.143228081272687 0.432376174237724 no 1918 0.443055026403219 2660 338 A COX inhibitor and kinase inhibitor.
SGTC_812 4251-0442 148 µM -0.143902739871923 0.432089252460526 no 1919 0.442788636052049 2638 5723007
SGTC_2161 5662504 8.5105 µM -0.144482588364406 0.431842680555691 no 1920 0.442559702329508 2687 2859334
SGTC_3215 9129942 49.47 µM -0.144793444371101 0.431710504610923 no 1921 0.442436979156993 2707 17682944
SGTC_2019 4016004 108 µM -0.146565802113451 0.430957044753888 no 1922 0.441737374038547 2740 45595336
SGTC_26 0302-0163 425.158 µM -0.146956478834872 0.430790995034142 no 1923 0.441583186065395 2671 3100915
SGTC_2401 5128683 200 µM -0.147936477474079 0.430374519127531 no 1924 0.441196450030943 2707 708373
SGTC_1979 st071809 45.3 µM -0.148684038691001 0.430056875589569 no 1925 0.440901478255542 2805 4976333
SGTC_2409 alverine citrate 63.97 µM -0.149161988486031 0.429853815374442 no 1926 0.440712906590383 2946 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_532 1548-0774 215 µM -0.150840694157818 0.429140753248366 no 1927 0.440050692109429 2887 5932993
SGTC_3243 9134147 49.47 µM -0.15143017960485 0.428890412828104 no 1928 0.439818192039636 2687 24282180
SGTC_2321 7390090 138.78 µM -0.151902365841343 0.428689907214229 no 1929 0.439631971139312 2760 649046
SGTC_2695 st077686 51.995 µM -0.155751209932608 0.427056253847456 no 1930 0.438114564998238 2752 2876092
SGTC_2569 tetrandrine 100 µM -0.155913450009269 0.426987417828685 no 1931 0.438050621695174 2746 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2446 5162541 200 µM -0.155958508449137 0.426968300606292 no 1932 0.43803286320426 2666 1549321
SGTC_2056 5235370 200 µM -0.1560647151407 0.426923240316472 no 1933 0.437991005378676 2735 5511916
SGTC_1870 st057514 26.5 µM -0.15884050584145 0.425745896054383 no 1934 0.43689726743549 2661 5393161
SGTC_1300 1094-0077 113 µM -0.15965295677407 0.425401421854368 no 1935 0.436577230247653 2697 5532636
SGTC_2858 9025781 8.96 µM -0.160685101242079 0.424963881091522 no 1936 0.436170712214809 2796 4894980 YPL153C RAD53
SGTC_1788 fluconazole 20 µM -0.16095821015693 0.42484812176755 no 1937 0.436063157431233 2772 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_526 4469-0568 170 µM -0.161222279927017 0.424736199917015 no 1938 0.435959166907264 2675 2901964
SGTC_3008 9078912 71.4286 µM -0.161521791135384 0.4246092641099 no 1939 0.435841224923956 2725 16648731
SGTC_999 SEC7.066 22.7 µM -0.162203756231331 0.424320269756188 no 1940 0.435572700963882 2718 740511 YDR170C SEC7
SGTC_594 1487-1584 10.8 µM -0.163544898173654 0.423752056775127 no 1941 0.435044712678647 2720 5013332
SGTC_632 0781-2353 4.65 µM -0.164752891973558 0.423240391435456 no 1942 0.434569241996255 2788 6811515 YHR007C ERG11
SGTC_1689 st020265 53.493 µM -0.165186034987186 0.423056958176434 no 1943 0.434398778366928 2816 5758320 YPR016C TIF6
SGTC_1137 ixabepilone 100 µM -0.165400968252291 0.422965941520839 no 1944 0.434314195808588 2689 154225 A novel microtubule stabilizer.
SGTC_1921 5740136 50 µM -0.166035744407568 0.422697160232883 no 1945 0.434064410298732 2731 1774243
SGTC_785 1270-0111 65.3 µM -0.166296865272496 0.422586605078279 no 1946 0.433961666425083 2693 6741994
SGTC_282 k297-0036 65.7 µM -0.16648739598542 0.422505940716973 no 1947 0.43388670064836 2833 5061378
SGTC_777 1315-0167 517 µM -0.167428389353916 0.422107603171437 no 1948 0.433516494482964 2792 4221767
SGTC_2128 5255449 168.493 µM -0.167885551256173 0.421914107953821 no 1949 0.433336658608116 2722 736008
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.168997898378564 0.421443382340388 no 1950 0.432899147237301 2653 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2118 5526350 200 µM -0.169354838715686 0.42129235526396 no 1951 0.43275877190438 2853 743594
SGTC_678 1218-2179 85.9 µM -0.170212458967635 0.420929530008416 no 1952 0.432421526928371 2693 6820081 YOR116C RPO31
SGTC_2906 7926292 26.41 µM -0.170567920771899 0.420779167824322 no 1953 0.432281761870557 2841 2966319
SGTC_1004 4084-0029 199 µM -0.172209810574054 0.420084790240028 no 1954 0.431636292691387 2850 716894 YLR208W SEC13
SGTC_2387 9077560 195.08 µM -0.172369136352458 0.420017422398008 no 1955 0.431573667309257 2704 5303272
SGTC_1563 conessine 56.1 µM -0.172563996845588 0.419935032571008 no 1956 0.431497076813739 2816 441082 An anti-amoebic, histamine inhibitor.
SGTC_1070 indatraline 8.81 µM -0.173690562581395 0.419458773222688 no 1957 0.431054327378892 2732 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1903 st060211 78.3 µM -0.174464930012639 0.419131475225809 no 1958 0.430750044926423 2884 688960
SGTC_1131 3454-3128 32.3 µM -0.175704467203475 0.418607682818639 no 1959 0.430263062793372 2901 710982
SGTC_1673 st016611 27.3 µM -0.17634540198256 0.418336898929527 no 1960 0.430011297629294 2932 5226799
SGTC_2370 9071495 200 µM -0.176946663793875 0.418082911361489 no 1961 0.429775142242363 2776 21791103
SGTC_1342 1486-1464 234 µM -0.176975767933145 0.41807061793327 no 1962 0.429763711753605 2730 3253938
SGTC_611 3453-1652 23.7 µM -0.17701411307847 0.418054421277169 no 1963 0.429748652001024 2784 1560575
SGTC_761 k216-0224 480 µM -0.178050077882858 0.41761689143227 no 1964 0.429341823773619 2746 1340404
SGTC_2086 5274770 176.623 µM -0.179146670270521 0.417153867207454 no 1965 0.42891126856879 2789 689278
SGTC_2476 5806916 10.51 µM -0.180148392010946 0.41673100146145 no 1966 0.428518036341092 2738 2870194
SGTC_266 formosanin C 406 nM -0.181942641701484 0.415973819922734 no 1967 0.427813869856988 2831 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2268 7933382 153.85 µM -0.182092298824798 0.415910677984783 no 1968 0.427755146173083 2693 935025 YOR257W CDC31
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.182297379608382 0.41582415573853 no 1969 0.427674677500102 2725 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1760 st045453 10.4495 µM -0.183082449943256 0.415492977421061 no 1970 0.427366662971753 2798 3323419 YIL048W NEO1
SGTC_2045 5106652 78.05 µM -0.183871405572388 0.415160220576911 no 1971 0.427057168684909 2865 673349
SGTC_3345 9148410 3.559 µM -0.185258177040839 0.414575471297154 no 1972 0.426513270021916 2843 4903596
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.185305911093951 0.414555347007391 no 1973 0.426494550970572 2733 4174840
SGTC_3297 9117502 71.43 µM -0.186284238624898 0.414142941528512 no 1974 0.426110933442319 2723 7453720
SGTC_899 1083-0020 478 µM -0.186404948723164 0.414092063784966 no 1975 0.42606360596223 2908 767123
SGTC_83 0170-0301 39.027 µM -0.186938868680281 0.413867040738913 no 1976 0.425854281774162 2726 3089716
SGTC_2412 st077135 33.4 µM -0.188094582802101 0.413380056600934 no 1977 0.425401253802549 3022 13258915
SGTC_3065 9113888 49.47 µM -0.189569940586787 0.412758577648826 no 1978 0.424823071990427 2931 16648368
SGTC_443 clozapine 122 µM -0.189789342165767 0.412666175676171 no 1979 0.424737103913716 2705 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1887 st057648 70.8 µM -0.190428134325332 0.412397173028125 no 1980 0.424486826507687 2892 688672
SGTC_2617 dihydrotanshinone i 20.83 µM -0.190547939191342 0.412346726413995 no 1981 0.424439890603851 2751 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1453 4237-0541 195 µM -0.19065170961728 0.412303032642612 no 1982 0.424399237372045 2807 739892
SGTC_3229 9132204 49.47 µM -0.190948179087363 0.412178206638417 no 1983 0.424283096554486 2727 17682924
SGTC_1916 st067606 49.2 µM -0.191718507255193 0.411853907933429 no 1984 0.423981354105705 2857 19590279
SGTC_3121 9125696 49.47 µM -0.19188126436325 0.411785396883609 no 1985 0.423917606806198 2706 1235365
SGTC_1333 1482-0047 286 µM -0.192015367165453 0.411728949610632 no 1986 0.423865084073768 2795 3811116
SGTC_354 2783-3500 4.88 µM -0.192108600696904 0.411689706327386 no 1987 0.423828569005666 2772 6740761
SGTC_690 glyoxal 20.3 µM -0.192675252821287 0.411451213621758 no 1988 0.42360665283402 2753 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2878 9043973 25.97 µM -0.193250205487603 0.411209260819269 no 1989 0.423381510710232 2918 6465167
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.193769014337853 0.410990963558082 no 1990 0.423178375060164 2847 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1498 4478-3555 97.6 µM -0.193915976863547 0.410929131691915 no 1991 0.423120836712788 2771 3437919
SGTC_1726 st035556 14.5795 µM -0.195239274467528 0.41037247764103 no 1992 0.422602817021541 2971 5919439
SGTC_406 estrone 100 µM -0.196010259081831 0.410048240922499 no 1993 0.422301068084856 2934 5870 A steroid.
SGTC_621 3584-0052 32.1 µM -0.196767145204603 0.409729993119658 no 1994 0.422004881386692 2788 2273927
SGTC_2075 5212009 200 µM -0.197545993799683 0.409402572836746 no 1995 0.421700146323152 2871 780898
SGTC_1085 doxorubicin 7.67 µM -0.197845369672688 0.40927673496558 no 1996 0.42158302392147 2847 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_506 n9-isopropylolomoucine 153 µM -0.200311133266635 0.408240647294611 no 1997 0.420618627957457 2889 6610355
SGTC_2214 7179297 48.276 µM -0.200831143980591 0.408022225941797 no 1998 0.420415304828805 2753 769744
SGTC_2372 9071633 200 µM -0.201137482286926 0.407893567297954 no 1999 0.420295537110817 2822 21321366
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.201161507642715 0.407883477338512 no 2000 0.420286144336811 2737 6312947
SGTC_2155 5570423 76 µM -0.201276554779857 0.407835161691816 no 2001 0.420241166994913 2777 797402
SGTC_2474 5321570 43.32 µM -0.201606436800774 0.407696630918966 no 2002 0.420112206359946 2898 2841384
SGTC_2514 salinomycin 42.74 µM -0.202083262428629 0.407496412996329 no 2003 0.419925816285892 2914 23682228 A polyether potassium ionophore.
SGTC_2367 9070478 135.38 µM -0.202132089161141 0.407475912132883 no 2004 0.419906731038082 2751 572802
SGTC_207 4185-0010 4.486 µM -0.202134288992114 0.407474988496571 no 2005 0.419905871179136 2824 3761753
SGTC_452 diindolylmethane 8 µM -0.202870180828446 0.407166040736796 no 2006 0.419618250934788 2872 3071 Inhibits expression of several cancer promoting factors.
SGTC_1912 st060209 90.8 µM -0.203896122984432 0.406735418239516 no 2007 0.419217337425103 2837 688787
SGTC_2163 5671233 125 µM -0.20413182197128 0.40663650333917 no 2008 0.419125243762996 2926 701023
SGTC_593 1203-0218 61.7 µM -0.204149020700326 0.406629285846851 no 2009 0.41911852395018 2902 3666956
SGTC_2675 theaflavin digallate 100 µM -0.205237742228848 0.406172465619403 no 2010 0.418693191496756 2794 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1505 k297-0037 20.6 µM -0.205485342910334 0.406068591841075 no 2011 0.418596474217487 2783 4089396
SGTC_2580 diallyl disulphide 81.36 µM -0.206664992452821 0.405573794553271 no 2012 0.418135749556744 2795 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2393 9031399 185.94 µM -0.206733012671441 0.405545268451873 no 2013 0.418109186956478 2922 1526623 YDL150W RPC53
SGTC_2516 gossypol 71.55 µM -0.207133236336377 0.405377434097652 no 2014 0.417952903036241 2923 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2159 5658611 73.75 µM -0.208346569684176 0.404868727499838 no 2015 0.417479186007175 2780 793844
SGTC_800 3448-7362 155 µM -0.209236467127374 0.404495727946817 no 2016 0.417131822879617 2853 15991913
SGTC_53 0973-0023 39.979 µM -0.210277597990895 0.404059449247125 no 2017 0.416725509315302 2755 674768
SGTC_1160 4092-0570 10.5 µM -0.211058966080745 0.403732100682643 no 2018 0.416420629629929 2775 4994975
SGTC_1508 1080-0625 72.9 µM -0.211932952287368 0.403366030309419 no 2019 0.416079671133116 2753 767111
SGTC_258 haloperidol 50.781 µM -0.212830761362697 0.402990069843579 no 2020 0.415729484642512 2810 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2775 cyproheptadine 69.59 µM -0.213299468157964 0.40279383295398 no 2021 0.415546694178864 2834 2913 A selective serotonin reuptake inhibitor.
SGTC_2965 9082772 38.63 µM -0.213623921282733 0.40265800613807 no 2022 0.415420171751098 2924 16459634
SGTC_1299 1079-1439 3.74 µM -0.214141308088221 0.402441435209637 no 2023 0.415218431832208 2811 323161
SGTC_467 ro 31-8220 72.8 µM -0.214308810275221 0.402371327533573 no 2024 0.415153124018641 2853 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_857 0438-0306 1.35 µM -0.214811434592546 0.40216097407579 no 2025 0.414957168744373 2885 4686136
SGTC_3222 9128301 49.47 µM -0.21494967653325 0.402103123364105 no 2026 0.414903276855434 2816 4911358
SGTC_2975 9084847 53.72 µM -0.215235054739878 0.401983706677655 no 2027 0.414792030802407 2887 27211724
SGTC_3035 9091303 49.47 µM -0.215999899176172 0.401663702202276 no 2028 0.414493913077873 2788 25237002
SGTC_2111 5486399 200 µM -0.216212831104611 0.40157462499827 no 2029 0.414410926157102 2785 689674
SGTC_87 0100-0052 35.5 µM -0.216802631972772 0.40132791646479 no 2030 0.414181080363282 2828 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1813 st051246 8.6015 µM -0.218195557434419 0.400745424253171 no 2031 0.413638373175862 2856 5291959
SGTC_2281 7943571 200 µM -0.218465118731931 0.400632724811714 no 2032 0.41353336657546 2956 1244024
SGTC_480 am 92016 50 µM -0.218674881539721 0.400545031922928 no 2033 0.413451658531996 2844 2129 K+ channel blocker.
SGTC_579 4491-1009 110 µM -0.219056814453419 0.400385374927198 no 2034 0.413302895402524 2844 1271041
SGTC_182 3448-4371 550.524 µM -0.219278477878345 0.400292722001518 no 2035 0.413216563054185 2766 3491403
SGTC_1831 st055328 12 µM -0.22183177152023 0.399225878569262 no 2036 0.412222422741987 2960 1103068
SGTC_2908 7930301 100 µM -0.22256737318616 0.398918661128799 no 2037 0.411936115966407 2793 2223178
SGTC_1907 st060210 83.7 µM -0.224028473388719 0.398308631586525 no 2038 0.411367573849157 2983 688793
SGTC_1628 st004252 77.7 µM -0.225187041686945 0.397825089823211 no 2039 0.410916884910205 2949 692968
SGTC_1197 1601-0112 267 µM -0.225436296985155 0.397721080752448 no 2040 0.410819938684035 2812 7350313
SGTC_387 norethindrone acetate 66.7 µM -0.225695052482817 0.397613115136005 no 2041 0.410719303179952 2853 541197
SGTC_1090 efavirenz 20.7 µM -0.226474169673983 0.397288076222699 no 2042 0.410416323485086 2855 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_3054 9094397 49.47 µM -0.226651198378467 0.397214231777102 no 2043 0.410347488781365 2848 2598354
SGTC_2917 7979103 53.79 µM -0.227433772478622 0.396887838777402 no 2044 0.410043230815921 2965 2980565
SGTC_2848 9016370 25.97 µM -0.228355568725257 0.396503472187123 no 2045 0.40968491396576 2874 7894410
SGTC_1898 st060199 18.6 µM -0.229020012504733 0.396226477651508 no 2046 0.40942668086576 2808 688866
SGTC_1211 1056-0033 32.3 µM -0.230089971436261 0.39578054135896 no 2047 0.409010928744874 2874 6741922
SGTC_1708 st033234 31.827 µM -0.231557260029876 0.395169228309316 no 2048 0.408440953406696 2939 674664
SGTC_570 0987-0065 62.6 µM -0.23212239729369 0.394933845197192 no 2049 0.408221474693859 2762 3104428
SGTC_2166 5933061 31.504 µM -0.236230746874898 0.393223850172956 no 2050 0.406626811014377 3330 2877375
SGTC_701 4424-0219 185 µM -0.2371102958161 0.392858026845003 no 2051 0.406285612596804 2985 2911779
SGTC_1266 0828-0227 32.9 µM -0.238286355644575 0.392369026144262 no 2052 0.405829501612235 2945 3913820
SGTC_522 1273-0010 11.6 µM -0.238624713097266 0.39222836998456 no 2053 0.405698300175082 3059 5705015
SGTC_1465 k213-0056 144 µM -0.2387089630888 0.392193349211075 no 2054 0.405665633057107 2811 24048857 YMR208W ERG12
SGTC_2252 omeprazole 400 µM -0.239528109630714 0.391852894492422 no 2055 0.405348051201219 2888 4594 A proton pump inhibitor.
SGTC_3122 9126309 49.47 µM -0.2401653766155 0.391588090031622 no 2056 0.405101026850689 2850 17591206
SGTC_1724 st037281 8.293 µM -0.240564669942857 0.391422196691239 no 2057 0.404946267692338 2820 574124 YDL195W SEC31
SGTC_3232 9132874 49.47 µM -0.241752878583846 0.390928651719464 no 2058 0.404485826684723 2833 3784940
SGTC_2575 plumbagin 510 nM -0.241792042005936 0.390912387435471 no 2059 0.404470652771674 2787 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1355 1499-0035 1.68 µM -0.243030200899812 0.390398287579955 no 2060 0.403991000876213 2828 1548538
SGTC_2883 9059145 45.46 µM -0.243304211381044 0.390284540683402 no 2061 0.403884871097034 2781 16476510
SGTC_2801 7907800 81.82 µM -0.243622035233035 0.390152617798422 no 2062 0.403761780379878 2925 6620925
SGTC_2070 5230947 200 µM -0.245723057351376 0.3892808407079 no 2063 0.402948311074212 2938 2835538
SGTC_954 1189-0853 2.85 µM -0.246154732352629 0.389101794635272 no 2064 0.402781227942591 2794 2828194
SGTC_2082 5219693 150 µM -0.247389355516817 0.388589839418652 no 2065 0.402303455642857 2828 2834649
SGTC_2287 7945887 168.79 µM -0.24800135482198 0.388336136286134 no 2066 0.40206667927389 2944 1245853
SGTC_2614 arthonioic acid 13.39 µM -0.248170047205624 0.388266213553986 no 2067 0.402001420203304 2801 6710684
SGTC_3129 9127257 49.47 µM -0.251019702226337 0.387085584952923 no 2068 0.400899438298397 2872 837894
SGTC_417 st075190 100 µM -0.251034613002018 0.387079410067968 no 2069 0.40089367426022 2990 222757
SGTC_1386 3228-0095 33.8 µM -0.251038575092621 0.387077769282638 no 2070 0.400892142643898 2979 870181
SGTC_845 0330-0138 4.51 µM -0.253779174079697 0.385943314333735 no 2071 0.399833081758007 2938 9039800
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.25406696255993 0.385824242356043 no 2072 0.399721913069064 2842 66535 A nucleotide analog.
SGTC_830 4076-0286 57.8 µM -0.254212073346289 0.385764207102058 no 2073 0.399665861871615 2861 6866659
SGTC_586 0957-0265 8.15 µM -0.255122314369997 0.385387684531378 no 2074 0.399314314957609 2917 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1301 naphtanilide LB 4.81 µM -0.255491844031219 0.38523485883278 no 2075 0.399171621079913 2986 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2058 5236698 133 µM -0.255661598131551 0.385164659915913 no 2076 0.399106075049071 2885 766665
SGTC_859 0439-0102 54.6 µM -0.256760398346194 0.38471036090855 no 2077 0.398681871447846 2975 610143
SGTC_2684 capsaicin 100 µM -0.25761656317524 0.384356489176199 no 2078 0.398351422758428 2951 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1966 st070145 16.1 µM -0.258141699219489 0.384139486569978 no 2079 0.398148775263011 2812 3748532
SGTC_819 1013-0258 27.7 µM -0.259251332291925 0.383681071058793 no 2080 0.397720663560126 2883 5753198
SGTC_751 0833-0568 350 µM -0.259573088301353 0.383548176495973 no 2081 0.397596548673841 2937 6954252
SGTC_3161 9100388 49.47 µM -0.260366639153287 0.383220475563863 no 2082 0.397290486917152 2877 25236368
SGTC_571 k831-0106 44.2 µM -0.261517585132094 0.382745334973139 no 2083 0.396846695133857 2936 4783639
SGTC_2233 sulbentine 40.3845 µM -0.262425274439981 0.382370741482903 no 2084 0.39649679455003 2883 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2582 agaric acid 100 µM -0.263411320243524 0.381963935838104 no 2085 0.396116783161925 2984 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2456 5770359 74.46 µM -0.26368808701288 0.381849775612282 no 2086 0.396010137965398 3020 3118787
SGTC_1884 5633444 25 µM -0.263805634412999 0.3818012929941 no 2087 0.395964846350194 3032 5724239
SGTC_2664 lyso-paf C-16 73.48 µM -0.265529540081644 0.381090478612021 no 2088 0.395300778306988 2881 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2870 9038528 12.99 µM -0.266828004708643 0.38055535007786 no 2089 0.39480079554521 2998 6463316
SGTC_2537 larixol 68.93 µM -0.267909796587511 0.380109692010561 no 2090 0.394384376343473 2830 6708759
SGTC_597 k018-0003 82.8 µM -0.268113049795987 0.380025976979765 no 2091 0.394306150588729 2992 6786234
SGTC_55 0767-0285 6.563 µM -0.271023008044489 0.37882805436709 no 2092 0.393186668215198 2998 3116166
SGTC_1313 1220-0047 237 µM -0.271911330858801 0.378462595777076 no 2093 0.392845099309992 2942 3528706
SGTC_2129 girgensonine 121.053 µM -0.272117966262809 0.378377600939345 no 2094 0.392765657771392 2957 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1081 sertraline 6 µM -0.272191841518156 0.378347215438072 no 2095 0.392737257313928 2999 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_869 0564-0080 44.1 µM -0.272442556523292 0.378244099900221 no 2096 0.392640877190461 2934 6843321
SGTC_3057 9095946 49.47 µM -0.272769427868595 0.378109675359249 no 2097 0.392515230854458 2851 24540043
SGTC_3025 9087895 49.47 µM -0.27279366255479 0.378099709528236 no 2098 0.392505915710094 3023 17173641
SGTC_2359 9039622 200 µM -0.273952392290195 0.377623309376337 no 2099 0.392060603942865 2862 6463596
SGTC_2728 chlorpromazine 9.18 µM -0.274032847916931 0.377590237750998 no 2100 0.392029689258278 2862 2726 A thorazine and dopamine antagonist.
SGTC_2935 9038016 29.96 µM -0.274703311360926 0.377314675840792 no 2101 0.391772093453413 3036 6463195
SGTC_939 1165-0479 45.3 µM -0.275510932971202 0.376982824565672 no 2102 0.391461863712705 3018 1377347
SGTC_300 r073-0011 5.04 µM -0.277799960466604 0.376042758819387 no 2103 0.390582960765425 2964 2735780
SGTC_1695 st026914 34.495 µM -0.278112027945101 0.375914654680441 no 2104 0.390463181434931 2874 3289191
SGTC_1480 1070-0044 41.2 µM -0.278210929104988 0.375874058467985 no 2105 0.390425222856315 2973 3124987
SGTC_1706 st031321 9.9705 µM -0.279161373283308 0.375483997310777 no 2106 0.390060492665097 3001 6103185
SGTC_2989 9073649 71.4286 µM -0.281047216683594 0.374710426504208 no 2107 0.389337092498925 2915 21367202
SGTC_57 miconazole 162.5 nM -0.281068225821846 0.374701811412166 no 2108 0.389329035652292 2846 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_527 4476-4215 268 µM -0.281202532619673 0.374646738502387 no 2109 0.389277531129019 2918 4418754
SGTC_2619 obliquin 87.91 µM -0.282089697150978 0.374283018268183 no 2110 0.388937366526137 2890 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1607 st000305 50.6 µM -0.282393089788481 0.374158658829564 no 2111 0.388821056512085 3057 5457690
SGTC_474 dl-dihydrosphingosine 5 µM -0.284356130033899 0.373354333397674 no 2112 0.388068737516383 3048 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_622 1348-1566 26.3 µM -0.284513778239041 0.373289763356646 no 2113 0.388008338317271 2993 7340407
SGTC_3275 9138069 49.47 µM -0.284612759588602 0.373249224086552 no 2114 0.387970417327313 3005 17617007
SGTC_1418 3966-3099 2.4 µM -0.285719333882991 0.37279610589767 no 2115 0.38754654771761 2995 740335
SGTC_549 1661-1316 519 µM -0.28599515485106 0.372683190559301 no 2116 0.387440916254752 3043 2857282
SGTC_51 1013-0126 23.419 µM -0.28621390159992 0.372593647991186 no 2117 0.387357148493137 3179 1627850
SGTC_1681 tripelennamine 100 µM -0.286486324515747 0.372482143058356 no 2118 0.38725283309683 2901 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1634 st006576 41 µM -0.287331630757746 0.372136220353999 no 2119 0.386929202724952 3104 3915356
SGTC_1958 st076513 41.9 µM -0.287643339436359 0.372008686557727 no 2120 0.386809883082241 2895 732122 YGL099W LSG1
SGTC_3143 9086658 49.47 µM -0.289514725613629 0.371243315402266 no 2121 0.386093756379435 2970 25236626
SGTC_669 0108-0021 26.2 µM -0.289691851178134 0.371170899805118 no 2122 0.386025995480391 3103 17201
SGTC_3114 9122766 49.47 µM -0.292467405419813 0.370036745999391 no 2123 0.384964638826473 2984 17176985
SGTC_2354 9060492 162 µM -0.293815215102158 0.369486407386649 no 2124 0.384449554009622 3064 6471895
SGTC_2171 5739187 198.077 µM -0.294005641849753 0.369408673726439 no 2125 0.38437679611706 2871 2262761
SGTC_1158 4092-0494 91.8 µM -0.294398484455537 0.369248329228305 no 2126 0.384226712427126 3065 1148199
SGTC_1552 6-methylflavone 10.6 µM -0.294572639836983 0.369177252418331 no 2127 0.384160182725427 2957 689013
SGTC_363 0455-0021 3.06 µM -0.294600226866487 0.369165993928435 no 2128 0.38414964442163 2904 4597466
SGTC_2443 5493264 126.67 µM -0.295076295631153 0.36897172410174 no 2129 0.383967798641597 3089 5340055
SGTC_919 tnp00227 403.569 nM -0.295468684269701 0.368811626861406 no 2130 0.383817935676158 2947 1269246 A methoxyflavone. YNL221C POP1
SGTC_383 2324-0395 7.37 µM -0.29688943392834 0.368232141913355 no 2131 0.383275461592371 3055 3146421
SGTC_714 4296-0578 26.1 µM -0.297427479103818 0.368012766149447 no 2132 0.383070083546385 2925 1589775
SGTC_2346 9031566 143.75 µM -0.298408800541488 0.36761276538041 no 2133 0.382695586509633 3028 4771086
SGTC_1464 k208-0027 110 µM -0.298739622067501 0.367477950092643 no 2134 0.382569361359716 3127 X1464
SGTC_1775 st081588 35.1725 µM -0.300349798168534 0.366822009947166 no 2135 0.381955176054095 2939 1426443 YGL099W LSG1
SGTC_2627 acetyl isogambogic acid 100 µM -0.300799915920811 0.366638714152179 no 2136 0.381783536260593 3021 6857789 A caspase activator and apoptosis inducer.
SGTC_92 0063-0024 660.874 µM -0.301384880010319 0.366400552021964 no 2137 0.381560511321955 2893 3594437
SGTC_3127 9126946 49.47 µM -0.302428500304107 0.365975780532393 no 2138 0.381162715604898 3020 27243249
SGTC_1802 st050112 57.9 µM -0.303481917166564 0.365547188204867 no 2139 0.380761313046462 2918 4662563
SGTC_1017 4239-0030 168 µM -0.304123055662858 0.365286417230387 no 2140 0.380517071184397 2950 1149593
SGTC_111 0083-0039 52.457 µM -0.30465381695346 0.365070587206574 no 2141 0.380314913568604 2901 759313
SGTC_33 0986-0033 35.816 µM -0.305548843385706 0.364706728376549 no 2142 0.379974087843433 2948 2848082
SGTC_194 1486-1323 56.904 µM -0.306516463738471 0.36431349469779 no 2143 0.37960572322754 2988 5178754
SGTC_2822 7994718 71.43 µM -0.306767068273502 0.36421167414927 no 2144 0.379510338066941 2903 1018011
SGTC_2341 7987486 176.74 µM -0.306768629957579 0.36421103966753 no 2145 0.379509743681342 3106 1258686
SGTC_2941 9056145 11.23 µM -0.308546868382391 0.363488817987617 no 2146 0.378833121386916 2955 2119517
SGTC_2349 9023730 187.07 µM -0.308609104105583 0.363463550061678 no 2147 0.378809447314875 3096 4126287
SGTC_995 3931-2021 34.6 µM -0.309852510446941 0.362958847265086 no 2148 0.378336558874945 3054 730143
SGTC_2154 5570129 200 µM -0.311853715660028 0.362147051290056 no 2149 0.377575849510905 2963 673366
SGTC_740 k014-0057 261 µM -0.312436265720999 0.361910854082231 no 2150 0.377354496374225 3060 4012779
SGTC_2330 7979373 200 µM -0.313160357500077 0.361617341541732 no 2151 0.37707941740803 2945 1863007
SGTC_154 3389-1638 511.116 µM -0.31378810217317 0.361362949427747 no 2152 0.37684099070986 3031 5238686
SGTC_993 3909-8757 62.7 µM -0.315097413434444 0.360832551317658 no 2153 0.376343846173399 2991 4288324 YLR208W SEC13
SGTC_2730 imipramine 71.33 µM -0.315267106790032 0.360763828605991 no 2154 0.37627942872368 2980 3696 A tricyclic antidepressant.
SGTC_1796 st049173 110.4 µM -0.315490264075768 0.360673460822406 no 2155 0.3761947210287 3073 94134
SGTC_3038 9091290 49.47 µM -0.316088034067052 0.360431431562581 no 2156 0.375967844462114 3123 25236843
SGTC_1383 3049-0032 20.7 µM -0.316332397726238 0.36033250800381 no 2157 0.375875111449113 3108 712864
SGTC_1799 st045822 46.1415 µM -0.317197096106874 0.359982534992452 no 2158 0.375547026607123 3106 3674992
SGTC_698 k064-0052 127 µM -0.317272691283809 0.359951944611987 no 2159 0.375518348472812 3013 5088751
SGTC_3140 9094243 49.47 µM -0.318740009528726 0.359358356794419 no 2160 0.374961836292855 3015 19291112
SGTC_125 0133-0007 11.75 µM -0.319011142857328 0.359248709816281 no 2161 0.374859031565814 3107 26541
SGTC_989 1501-0895 10.3 µM -0.319957938831296 0.358865914180891 no 2162 0.37450010785087 3081 2830112
SGTC_2290 7904846 200 µM -0.320550922311711 0.358626239325217 no 2163 0.374275367319139 3020 2962154
SGTC_1659 st012954 42.1 µM -0.320898639695525 0.358485723160605 no 2164 0.37414360241518 3096 24207262
SGTC_1637 st007924 17.4 µM -0.32194427680279 0.358063285964754 no 2165 0.373747454684213 2948 683336
SGTC_2956 9076196 2.52 µM -0.322069352066143 0.358012767204459 no 2166 0.373700077871067 3098 16423868
SGTC_2512 diallyl trisulfide 49.23 µM -0.322225516901673 0.357949694641976 no 2167 0.373640927428736 3020 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2069 5228469 200 µM -0.322280487148482 0.357927493931791 no 2168 0.373620107096101 3082 2835210
SGTC_2602 kawain 100 µM -0.322865075764256 0.357691427179395 no 2169 0.373398713248046 3008 5369129
SGTC_2212 7123476 200 µM -0.323150320784293 0.357576260176291 no 2170 0.373290701175087 2993 1085715
SGTC_39 0986-0283 58.349 µM -0.323626421457642 0.357384064542837 no 2171 0.373110441081996 3166 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2987 9018338 71.43 µM -0.323885815149561 0.357279365910284 no 2172 0.373012241750689 3078 5055682
SGTC_675 1309-0189 238 µM -0.323912014719766 0.357268791619786 no 2173 0.373002323771206 3021 4246530
SGTC_732 3970-1727 52.7 µM -0.324301569235345 0.357111578211766 no 2174 0.372854865876807 3086 1275699
SGTC_530 4358-1714 28 µM -0.324508474994348 0.35702808664234 no 2175 0.372776553506614 3056 1564641
SGTC_1826 st055655 41.6 µM -0.324625110450605 0.356981024380538 no 2176 0.372732410126411 3048 676168
SGTC_837 0091-0265 12.5 µM -0.327151787264232 0.355962048735889 no 2177 0.371776542158723 2982 759367
SGTC_2626 ethyl orsellinate 100 µM -0.328202212464876 0.355538728128694 no 2178 0.371379387556231 2964 75653 A natural product.
SGTC_309 k408-0051 1.48 µM -0.329087354444433 0.355182154809892 no 2179 0.371044831046956 3035 3640463
SGTC_1438 4092-1045 4 µM -0.329194711978315 0.355138915184645 no 2180 0.371004259814352 2987 1351342
SGTC_1479 0549-0158 134 µM -0.331346144558291 0.354272791992497 no 2181 0.37019151983274 3022 5440202
SGTC_848 0368-0089 85.6 µM -0.334700397259584 0.352923941679184 no 2182 0.368925550873905 3112 762535
SGTC_873 0591-4978 488 µM -0.335011780772525 0.352798817992462 no 2183 0.368808099727004 3198 3305145
SGTC_2607 solasodine 47.35 µM -0.335136802559935 0.35274858478549 no 2184 0.368760946045008 3006 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_693 4161-2696 114 µM -0.335195739826844 0.35272490493991 no 2185 0.368738717731545 3094 805759
SGTC_716 1683-5115 658 µM -0.33542496979928 0.352632810229138 no 2186 0.368652267344094 2988 723597
SGTC_1332 1480-0653 17.5 µM -0.335927500698291 0.352430945226344 no 2187 0.368462769183354 3133 5749438
SGTC_1123 mangostin 811.285 nM -0.336616860084443 0.352154099451451 no 2188 0.368202872364926 3057 5281650 An antioxidant.
SGTC_3061 glucosamine 200 µM -0.337012317196359 0.351995319771621 no 2189 0.368053807466858 3098 91431 and experimental redox chemotherapeutic
SGTC_2384 9036245 200 µM -0.338224123073479 0.351508929314988 no 2190 0.367597149185631 3042 6462766
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.340713067438928 0.350510688331569 no 2191 0.366659800141967 2993 2346 DNA damaging agent; causes G2/M arrest.
SGTC_155 k072-0202 43.6 µM -0.341991508388882 0.349998344508234 no 2192 0.366178641361243 3057 5857737
SGTC_259 usnic acid 108.925 µM -0.342365236587251 0.349848621932592 no 2193 0.366038023327593 3215 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2950 9072895 21.46 µM -0.342558158518876 0.349771342897076 no 2194 0.365965442045513 3139 17332245
SGTC_2088 5278280 127.392 µM -0.342718987305393 0.349706924218759 no 2195 0.365904938544499 3103 791502
SGTC_3248 9135562 49.47 µM -0.344052280686388 0.349173051041058 no 2196 0.365403484512905 3063 17650701
SGTC_971 1315-0384 26.7 µM -0.347493204210116 0.347796627840669 no 2197 0.364110411534571 3031 6769120
SGTC_2332 7982454 138.89 µM -0.348238274500767 0.347498851340697 no 2198 0.363830622820994 3103 2981748
SGTC_1747 st037496 66.6 µM -0.348939010694093 0.347218879353117 no 2199 0.363567548675339 3030 723305
SGTC_1214 0358-0031 63.7 µM -0.349006037562263 0.347192103818217 no 2200 0.36354238845695 3257 4301366
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.3492037442499 0.347113129451232 no 2201 0.363468177715013 3034 229346 A bile salt which induces apoptosis.
SGTC_2806 7952793 58.44 µM -0.350412832369876 0.346630301136818 no 2202 0.363014448658225 3159 2972490
SGTC_1680 diphenhydramine 100 µM -0.350488155226524 0.346600230496058 no 2203 0.36298618894238 3053 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_1864 st057645 30.4 µM -0.351189649936131 0.346320223890473 no 2204 0.362723037198426 3093 688666
SGTC_2423 st077119 87.2 µM -0.351280646661768 0.346283908049632 no 2205 0.362688906339611 3052 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_94 0334-0113 514.748 µM -0.352315270188811 0.345871100082666 no 2206 0.362300918722878 3047 6795178
SGTC_637 1181-0519 7.26 µM -0.352526491130847 0.345786846814723 no 2207 0.362221727463535 3031 6252091 YGR060W ERG25
SGTC_2328 6201408 200 µM -0.3527492972068 0.345697980664714 no 2208 0.36213819907961 3147 2890418
SGTC_2606 farnesol 9.78 µM -0.353331724506989 0.345465719844113 no 2209 0.361919882322079 3192 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2638 epoxomicin 18 µM -0.355837749523406 0.344467029779057 no 2210 0.360981038456377 3146 9915668 A protesome inhibitor.
SGTC_774 k060-0086 136 µM -0.356265470050412 0.344296684510859 no 2211 0.360820882976321 3217 5911235
SGTC_1288 0973-0013 65.5 µM -0.356506128028219 0.344200853220001 no 2212 0.360730781838579 3142 4315430
SGTC_1294 1000-1494 117 µM -0.356794292135045 0.344086117896032 no 2213 0.360622904814672 3065 712797 YDL207W GLE1
SGTC_711 k292-0785 179 µM -0.35746564970438 0.34381886607689 no 2214 0.360371618640052 3009 4146315
SGTC_739 1486-1183 203 µM -0.358049424692047 0.343586542256383 no 2215 0.360153163247591 3171 4346692
SGTC_817 1391-0715 46 µM -0.358856507720489 0.343265446259032 no 2216 0.359851218596231 3075 1353946
SGTC_2151 5563267 85.4165 µM -0.359592136188366 0.342972876806902 no 2217 0.359576082579245 3061 5310824
SGTC_160 3453-0671 289.699 µM -0.359701985872938 0.342929196165542 no 2218 0.359535003400655 3032 5322268
SGTC_1495 4469-0029 237 µM -0.361613142645035 0.342169579991738 no 2219 0.358820571006833 3051 793680
SGTC_89 0302-0250 142.109 µM -0.36245006241188 0.341837135196964 no 2220 0.358507867271847 3051 4203518 YLR208W SEC13
SGTC_791 1348-1292 225 µM -0.363996574044036 0.341223146095863 no 2221 0.357930283838935 3099 5437054
SGTC_2818 7996756 12.99 µM -0.364460322853278 0.341039112430606 no 2222 0.357757148546868 2966 2241621
SGTC_577 r071-0003 38.6 µM -0.3650233271435 0.340815741128643 no 2223 0.357546996688537 3045 4568517 YMR134W ERG29
SGTC_1151 3909-8316 15.3 µM -0.366884554012266 0.34007769902813 no 2224 0.356852566695883 3156 800431
SGTC_330 1488-0319 80.1 µM -0.367652052308621 0.33977353704208 no 2225 0.356566348425748 3127 6846614
SGTC_783 0848-0141 92.7 µM -0.368828183184935 0.339307635100236 no 2226 0.35612789813802 3031 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1028 k015-0029 4.8 µM -0.369082585925244 0.339206890556271 no 2227 0.35603308423739 3038 4588309
SGTC_713 1488-1073 324 µM -0.369263343596322 0.339135316750536 no 2228 0.355965722684243 3066 3312542
SGTC_1927 st060202 13.8 µM -0.370807807468692 0.338523999234889 no 2229 0.355390342887763 3173 688887
SGTC_894 0960-0238 55.9 µM -0.372380667644184 0.337901879131553 no 2230 0.354804722809903 3181 6741907 YDL195W SEC31
SGTC_130 0136-0219 337.655 µM -0.372959782828955 0.33767293059964 no 2231 0.354589188242646 3011 234244
SGTC_2552 juarezic acid 87.02 µM -0.373092944182554 0.337620294819059 no 2232 0.354539634949973 3037 1549512
SGTC_2460 5552655 174.22 µM -0.37319117951938 0.337581466567499 no 2233 0.354503080242863 3180 5401989
SGTC_2770 toltrazuril 17.5 µM -0.37417570616862 0.33719242060265 no 2234 0.354136798531379 3136 68591 Kills coccidiodes.
SGTC_140 0062-0056 502.533 µM -0.374184980021197 0.337188756769952 no 2235 0.354133348943075 3021 3758964
SGTC_2924 9010168 62.78 µM -0.37448053209162 0.337072000728115 no 2236 0.354023418922132 3148 2993929
SGTC_564 3555-0129 330 µM -0.375302542137594 0.336747353227186 no 2237 0.353717737875629 3106 563260
SGTC_1189 1431-2119 7.28 µM -0.377451832133486 0.335899080372067 no 2238 0.352918926980994 3107 3107275
SGTC_582 0987-0078 156 µM -0.377714580338476 0.335795437212579 no 2239 0.352821317648992 3215 1625765
SGTC_3108 9121785 49.47 µM -0.378201731901288 0.335603309374504 no 2240 0.352640369491713 3088 17140271
SGTC_1696 st025591 34.7925 µM -0.378573069224702 0.335456886405035 no 2241 0.352502461901259 3073 2787147
SGTC_671 0560-0003 407 µM -0.378963574080707 0.335302932392308 no 2242 0.35235745676777 3087 3238678
SGTC_1734 st037168 69.4 µM -0.379141435595413 0.335232820806362 no 2243 0.35229141903382 3149 708907
SGTC_2722 naftopidil 47.16 µM -0.379771736712923 0.334984407371103 no 2244 0.352057432054065 3187 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_3078 9116413 49.47 µM -0.379965733715404 0.33490796405191 no 2245 0.351985425723096 2992 17177322
SGTC_2995 9067767 71.4286 µM -0.380190210658031 0.334819518836863 no 2246 0.35190211270397 3130 11673567
SGTC_2202 7226349 200 µM -0.380295552624048 0.33477801665065 no 2247 0.351863018234184 3051 844334
SGTC_752 1896-0090 130 µM -0.381400847675808 0.3343426788974 no 2248 0.351452916057131 3059 772567
SGTC_3286 9117135 37.221 µM -0.381886538169161 0.334151452490549 no 2249 0.351272762950759 3085 3438150
SGTC_3230 9131665 49.47 µM -0.382767601237926 0.333804669599624 no 2250 0.350946042911172 3054 15943720
SGTC_1745 st081495 74 µM -0.382806036969025 0.333789544678162 no 2251 0.350931792494925 3122 13842402 YBL026W LSM2
SGTC_2490 carminic acid 95.39 µM -0.383109293891933 0.33367021891242 no 2252 0.350819364434594 3121 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1132 3456-3614 2.5 µM -0.385145555170334 0.332869425483523 no 2253 0.350064789131067 3301 3125502
SGTC_3320 9137005 35.139 µM -0.387278041617951 0.332031606410989 no 2254 0.349275189948276 3134 4908713
SGTC_1688 st021091 57.6 µM -0.387417963074277 0.331976662846314 no 2255 0.349223403760546 3201 3656366
SGTC_1866 st057638 64 µM -0.387569134719035 0.331917305681533 no 2256 0.349167456931842 3095 688802
SGTC_2798 7813637 45.45 µM -0.389378393692036 0.331207232433193 no 2257 0.348498126369976 3215 956368
SGTC_2090 5301565 104.445 µM -0.389392523007598 0.331201689535988 no 2258 0.34849290111965 3086 2056344
SGTC_412 gemfibrozil 100 µM -0.389618480934435 0.331113051799635 no 2259 0.348409342115865 3153 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2726 cimetidine 79.27 µM -0.390311153231726 0.33084139248426 no 2260 0.348153238481979 3085 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2831 7999036 19.48 µM -0.390449918172939 0.330786980931579 no 2261 0.348101940858968 3295 2988270
SGTC_2434 5670830 169.91 µM -0.391096191985687 0.330533615609215 no 2262 0.347863067642898 3176 1549830
SGTC_1377 2944-0135 198 µM -0.391284516259893 0.330459799525571 no 2263 0.347793471311321 3137 1894137
SGTC_2727 riluzole 51.77 µM -0.39132366751241 0.330444454524474 no 2264 0.347779003381907 3136 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1185 1319-0113 81.3 µM -0.392079209557309 0.330148382093372 no 2265 0.347499844281931 3196 4672763
SGTC_3233 9132340 49.47 µM -0.392196702122307 0.330102350115297 no 2266 0.3474564403327 3091 17682950
SGTC_2540 epiandrosterone 100 µM -0.392540251520192 0.329967766922204 no 2267 0.347329538240614 3103 441302 A steroid.
SGTC_1719 st032227 49.2 µM -0.39271662256362 0.329898683285053 no 2268 0.347264396019416 3081 3125804
SGTC_562 3772-2733 112 µM -0.392778043333176 0.32987462644505 no 2269 0.347241711464851 3218 2876874 YIL048W NEO1
SGTC_3291 9121177 71.43 µM -0.393023086579809 0.329778656693952 no 2270 0.347151215003437 3108 17015612
SGTC_1251 0490-5699 265 µM -0.395147317501624 0.328947184278017 no 2271 0.346367084996757 3274 3883818
SGTC_3318 9139014 38.6185 µM -0.395285038264018 0.328893306381518 no 2272 0.346316269989634 3092 16643984
SGTC_1961 st076550 68.7 µM -0.395705727927952 0.328728749919238 no 2273 0.346161064716568 3197 1579337
SGTC_85 0868-0259 160.055 µM -0.396086387991654 0.328579879998954 no 2274 0.346020649850037 3146 83173
SGTC_1072 oxiconazole 14.9 nM -0.396872291570258 0.328272612055137 no 2275 0.345730818957694 3164 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_700 3453-2283 142 µM -0.396986778735367 0.32822786022579 no 2276 0.345688605137508 3267 565664
SGTC_2293 7624732 200 µM -0.398052762786778 0.327811296667804 no 2277 0.345295646606862 3072 894453
SGTC_2696 st077691 74.316 µM -0.398211537712351 0.327749269167202 no 2278 0.345237130941736 3250 757133
SGTC_180 1486-1293 102.781 µM -0.398299118104207 0.327715056775656 no 2279 0.345204855231281 3273 4140536
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.398330389861403 0.327702841131347 no 2280 0.345193331027395 3060 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2105 5350118 200 µM -0.398865326287473 0.327493908202568 no 2281 0.344996219590053 3142 2133313
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.399019506414169 0.327433699285925 no 2282 0.344939415660083 3228 1377
SGTC_2755 lomerizine 42.69 µM -0.39905767091447 0.327418796351116 no 2283 0.344925355414666 3135 3949 A calcium channel blocker.
SGTC_2106 5357045 167.29 µM -0.399152825742577 0.327381640342872 no 2284 0.344890300202768 3189 668842
SGTC_1614 st002383 48.6 µM -0.40098756802689 0.326665545861698 no 2285 0.344214638457578 3191 1947235
SGTC_2160 5660466 132.927 µM -0.401706516409874 0.326385116298402 no 2286 0.343950014103193 3200 2859134
SGTC_2479 5617353 43.85 µM -0.402252550105353 0.326172198549765 no 2287 0.343749085754374 3277 2731746
SGTC_1201 1889-3372 45.9 µM -0.402528030768915 0.326064800441823 no 2288 0.34364773169444 3108 5392199
SGTC_1060 3448-7350 82 µM -0.403136920096657 0.325827471771726 no 2289 0.343423750750716 3219 570178
SGTC_1960 st011366 51.8 µM -0.403547148329437 0.325667615625944 no 2290 0.343272878609263 3082 3972846
SGTC_2242 6630449 61.2675 µM -0.403552956047944 0.325665352726773 no 2291 0.343270742848411 3237 691249 YDR170C SEC7
SGTC_1109 tnp00067 928.257 nM -0.403614556253511 0.325641351433101 no 2292 0.343248089973982 3151 676295
SGTC_813 k007-0158 173 µM -0.40492326340927 0.325131610682574 no 2293 0.342766958890288 3160 6523916
SGTC_2136 5328288 199.296 µM -0.405188430736722 0.32502836796897 no 2294 0.342669504215515 3124 262395
SGTC_2227 7312221 64.1025 µM -0.405668900409862 0.324841331665646 no 2295 0.342492947992697 3138 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1928 4'-methoxychalcone 40.3 µM -0.408604392024579 0.32369956943879 no 2296 0.341415003497014 3307 641818
SGTC_801 0866-0028 10.1 µM -0.410188789462129 0.323084004498555 no 2297 0.340833731939785 3081 6849771
SGTC_952 1185-0122 232 µM -0.410449806877834 0.322982641271037 no 2298 0.34073800807548 3097 678600
SGTC_900 1112-0045 141 µM -0.411435948038748 0.322599802959882 no 2299 0.340376449552268 3162 56211 YIL048W NEO1
SGTC_2000 st075254 36.4 µM -0.412182662349576 0.32231003964198 no 2300 0.340102771983028 3173 17234175
SGTC_311 1315-0136 58 µM -0.412915745231085 0.322025671008561 no 2301 0.339834172383649 3304 6759207
SGTC_1359 1582-0056 520 nM -0.413801003625092 0.321682411153269 no 2302 0.33950992445343 3226 3661189
SGTC_1564 D-Arginine 115 µM -0.41468329217992 0.321340454241608 no 2303 0.339186882460596 3162 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_275 trichlorophene 5.69 µM -0.417471387332844 0.320260842017592 no 2304 0.338166824301475 3219 62616
SGTC_3313 9133968 57.047 µM -0.419672434861232 0.319409620421347 no 2305 0.337362382394912 3218 1494643
SGTC_1454 4239-0054 42.6 µM -0.419761247949284 0.319375293240993 no 2306 0.337329938432095 3318 1340767
SGTC_3311 9131146 2.8755 µM -0.422034979666088 0.318497000157759 no 2307 0.336499742805879 3173 4900406 YPR165W RHO1
SGTC_3329 9141233 27.5565 µM -0.422414528008498 0.318350488005577 no 2308 0.336361237786817 3284 4909101 YNL103W MET4
SGTC_2394 5221648 200 µM -0.423485210234987 0.317937339510414 no 2309 0.335970643476894 3261 788586
SGTC_2969 9091408 28.7 µM -0.423621522353086 0.317884756444158 no 2310 0.33592092831368 3102 4286311
SGTC_70 0141-0289 43.283 µM -0.426149637787814 0.316910190061328 no 2311 0.334999406188131 3187 352408
SGTC_1180 1193-0155 285 µM -0.426195780988932 0.316892414033205 no 2312 0.33498259575848 3266 2921347
SGTC_2887 9044784 58.44 µM -0.426980256681214 0.316590270359648 no 2313 0.334696854027694 3150 6465546
SGTC_3342 9147791 14.508 µM -0.427849171359829 0.316255747505373 no 2314 0.334380467482843 3153 1838168
SGTC_1900 st060200 72.8 µM -0.428633909912853 0.31595376073139 no 2315 0.334094831947523 3135 688945
SGTC_556 4058-0063 51.5 µM -0.428670137501616 0.315939822424021 no 2316 0.334081647853073 3205 6615692
SGTC_1102 cgs 12066b 26.1 µM -0.429494469468784 0.315622737306525 no 2317 0.333781708903157 3201 6438352 A 5-HT1B full agonist.
SGTC_2244 6635614 200 µM -0.430024039420791 0.315419106046693 no 2318 0.333589077176362 3027 836499
SGTC_1002 4049-0206 172 µM -0.430903188172884 0.315081177848518 no 2319 0.333269382599952 3151 4662749
SGTC_1314 1222-0010 41.1 µM -0.431021996395071 0.315035522069018 no 2320 0.333226188336187 3202 3526027
SGTC_1268 0828-0275 2.46 µM -0.432281921879614 0.314551530240123 no 2321 0.332768262351756 3258 745337
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.433707014657457 0.314004474387124 no 2322 0.332250606060773 3214 5379071
SGTC_767 0929-0023 86 µM -0.435255912015291 0.313410356434154 no 2323 0.331688341274195 3282 1204563
SGTC_2943 9068529 45.32 µM -0.43604236078463 0.313108879620542 no 2324 0.331402997709688 3231 3270634
SGTC_1753 st043925 64 µM -0.43607432014922 0.313096630975823 no 2325 0.331391404109153 3256 670181
SGTC_672 1441-0018 53.7 µM -0.436142461991112 0.313070515838293 no 2326 0.331366685468406 3142 251141
SGTC_1351 1496-0003 46.5 µM -0.436550967537301 0.312913977091744 no 2327 0.33121851436285 3299 3891978
SGTC_902 1120-0002 2.07 µM -0.437250058088875 0.312646164835556 no 2328 0.330965005014475 3200 3280475
SGTC_805 3852-0218 479 µM -0.439818321453606 0.311663147233196 no 2329 0.330034348429002 3169 6615355
SGTC_2963 9082507 9 µM -0.441277664570048 0.311105172053689 no 2330 0.329505996908126 3300 16459611
SGTC_3089 9117425 49.47 µM -0.441344643623198 0.311079573230757 no 2331 0.329481755466554 3238 9401657
SGTC_838 0109-0203 71.4 µM -0.441830467436459 0.310893922874675 no 2332 0.329305944791118 3198 759422
SGTC_134 0269-0018 6.916 µM -0.44444755821408 0.309894669303122 no 2333 0.328359517892117 3219 4378915
SGTC_1412 3909-8563 178 µM -0.444620760041405 0.309828587062108 no 2334 0.32829692112064 3302 23767530
SGTC_48 0382-0018 55 µM -0.445639203709519 0.309440141376216 no 2335 0.327928943542546 3429 762596
SGTC_936 3005-4620 401 µM -0.446827593440543 0.308987145440475 no 2336 0.327499773247115 3373 777207
SGTC_1720 st037298 9.481 µM -0.44842453798439 0.308378871960725 no 2337 0.326923417978195 3269 597396
SGTC_1169 aniline yellow 25.8 µM -0.449296754933419 0.30804686784452 no 2338 0.326608799196451 3199 6051 A DNA damaging agent.
SGTC_489 paxilline 115 µM -0.449597619259471 0.307932382065603 no 2339 0.326500302524862 3258 105008 A toxic potassium channel blocker.
SGTC_320 4092-0846 5.34 µM -0.449932805031122 0.307804858201087 no 2340 0.326379446252191 3258 1359356
SGTC_212 3807-4682 38.772 µM -0.452294524273811 0.306906983617253 no 2341 0.32552841007596 3273 3125501 YBL034C STU1
SGTC_3159 9100096 49.47 µM -0.454978411943018 0.305888032008879 no 2342 0.324562384943387 3165 25236875
SGTC_3240 9133527 49.47 µM -0.457513875780962 0.304926808251031 no 2343 0.323650865563307 3217 17617455
SGTC_1395 3486-0190 4.35 µM -0.459278451360119 0.304258630184153 no 2344 0.323017110009472 3374 6748079
SGTC_2083 5306046 65.942 µM -0.459379793299002 0.304220275631016 no 2345 0.322980728153885 3239 539837
SGTC_142 0335-0849 62.6745 µM -0.459775059562113 0.304070701083582 no 2346 0.322838843365646 3367 3889043 YPR107C YTH1
SGTC_1658 st012944 20 µM -0.460736699094441 0.303706939540044 no 2347 0.322493760915944 3272 24207260
SGTC_1271 0832-2808 169 µM -0.460964619291008 0.303620752135016 no 2348 0.322411994601684 3327 3663794
SGTC_920 mycophenolic acid 780.421 nM -0.461975557994057 0.303238600106067 no 2349 0.322049424188359 3212 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1403 3909-7815 62.9 µM -0.462071667995269 0.303202280087047 no 2350 0.322014963405854 3199 6615483
SGTC_1467 k284-1082 293 µM -0.462319968518043 0.303108456196919 no 2351 0.321925940938907 3286 3334705
SGTC_1759 st043059 70 µM -0.462990061313357 0.302855316927135 no 2352 0.321685745523249 3179 669426
SGTC_2024 5144227 134 µM -0.463237947256505 0.302761697667506 no 2353 0.321596909440208 3318 3475211
SGTC_3030 9087619 49.47 µM -0.463842047720742 0.302533600919914 no 2354 0.32138045776662 3244 25236973
SGTC_345 1362-0200 395 µM -0.463896160076099 0.302513172892096 no 2355 0.321361072046211 3227 1419823
SGTC_1339 1486-1321 22.7 µM -0.464489345842644 0.302289279093707 no 2356 0.321148595499265 3239 3469382
SGTC_1444 4112-3581 28 µM -0.465328324376319 0.3019727395502 no 2357 0.320848177014494 3257 2877249
SGTC_3167 9103034 49.47 µM -0.465548052997201 0.301889862399889 no 2358 0.320769516732266 3308 5127859
SGTC_2731 amoxapine 43.43 µM -0.465747840472057 0.301814515515259 no 2359 0.320698002131442 3298 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3276 9139060 49.47 µM -0.465812677309377 0.301790065079872 no 2360 0.320674794996758 3275 4870619
SGTC_2361 9034121 116 µM -0.469768560558262 0.300299960947354 no 2361 0.319260189308432 3233 6496917
SGTC_3274 9138298 49.47 µM -0.46980589434034 0.300285913890786 no 2362 0.319246851402524 3258 17015756
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.471586477511335 0.299616304105715 no 2363 0.318610990312215 3230 115019
SGTC_1177 0983-0204 23.6 µM -0.472129160144388 0.299412356358448 no 2364 0.318417299868014 3352 766818
SGTC_2420 aureobasidin a 50 nM -0.473343471525758 0.298956229284985 no 2365 0.317984076248179 3444 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1297 1068-0111 14.1 µM -0.474663806880307 0.298460635297236 no 2366 0.317513309509074 3219 767057
SGTC_1404 3909-7820 48.3 µM -0.474764797337767 0.298422743456379 no 2367 0.317477313406746 3340 23741373
SGTC_765 1319-0117 244 µM -0.47515037512699 0.298278093964534 no 2368 0.317339897510245 3235 3487746 YGL099W LSG1
SGTC_7 0192-1582 4.227 µM -0.476193196126203 0.297887039728832 no 2369 0.31696837315281 3287 252616
SGTC_2623 humulene 100 µM -0.476444755778498 0.297792740745569 no 2370 0.316878777954451 3302 6187145 An anti-inflammatory.
SGTC_2998 9066762 71.4286 µM -0.477086227577177 0.297552341979416 no 2371 0.316650360702679 3415 4945196
SGTC_429 1112-0049 25.5 µM -0.479440702875582 0.296670736217838 no 2372 0.315812571520743 3182 2836170
SGTC_1067 clotrimazole 1.36 µM -0.479471996425441 0.296659026772915 no 2373 0.315801442743781 3252 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1716 st033144 30.6155 µM -0.48080938562792 0.296158799382746 no 2374 0.315325989520244 3406 674617
SGTC_1037 k284-1091 78.7 µM -0.481416454212224 0.295931863609454 no 2375 0.315110272294965 3319 3334711
SGTC_2875 9039966 71.43 µM -0.481664352455504 0.295839216684112 no 2376 0.315022201653408 3281 6463691
SGTC_1618 st003135 44.5 µM -0.481794624564135 0.295790535474406 no 2377 0.314975924183926 3295 1270615
SGTC_422 cantharidin 155 µM -0.482198241492331 0.295639731774581 no 2378 0.314832562970775 3204 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2475 5812728 15.03 µM -0.486032520338016 0.294208893137413 no 2379 0.313472054482298 3246 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_276 colchicine 750 µM -0.486815563182947 0.293917078732204 no 2380 0.313194520138621 3397 2833 A microtubule depolymerizer.
SGTC_3223 9129970 49.47 µM -0.487874420409909 0.293522690370209 no 2381 0.312819396986228 3241 17248386
SGTC_2636 apigenin dimethyl ether 100 µM -0.489615349838468 0.292874786559955 no 2382 0.312203056225704 3386 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1461 k072-0203 53.8 µM -0.490045141996977 0.292714937458569 no 2383 0.31205097779708 3278 5418714
SGTC_961 1252-1571 372 µM -0.490145708627749 0.292677540380122 no 2384 0.312015397742932 3411 6813498
SGTC_1249 0481-0015 10.2 µM -0.490272825172339 0.292630273528398 no 2385 0.311970426949546 3221 4227577
SGTC_172 1112-0046 2.638 µM -0.491222484960095 0.292277265521309 no 2386 0.311634548744222 3226 2802135 YIL048W NEO1
SGTC_291 SEC14.278 35.5 µM -0.491362184516641 0.292225353049513 no 2387 0.31158515264396 3364 1068044
SGTC_3204 9114183 49.47 µM -0.49256656634537 0.291777981761899 no 2388 0.311159438261914 3210 17027248
SGTC_1817 st052116 64.4 µM -0.49270386908358 0.291727000513547 no 2389 0.311110921711122 3378 4361398
SGTC_2523 spermine 47.74 µM -0.493274566897508 0.291515141832677 no 2390 0.310909298206655 3329 1103 A DNA binding polyamine.
SGTC_2796 7949634 45.45 µM -0.493287192980993 0.291510455495612 no 2391 0.310904838142075 3283 2971588
SGTC_34 0469-0683 81.75 µM -0.493542950325827 0.291415535356026 no 2392 0.310814499854791 3336 3690923
SGTC_332 4112-0506 40.9 µM -0.494174903068857 0.291181058324607 no 2393 0.310591331207361 3284 2790355
SGTC_3337 9144342 33.5465 µM -0.494852376103867 0.290929789519959 no 2394 0.310352164857649 3359 17682949
SGTC_2724 maprotiline 69.64 µM -0.494958506120695 0.2908904360099 no 2395 0.310314705345078 3388 4011 A tricyclic antidepressant.
SGTC_2937 9044753 11.33 µM -0.494980475875337 0.290882289832253 no 2396 0.310306951174895 3281 6465530 YGL099W LSG1
SGTC_2326 6164455 177.58 µM -0.496127962845677 0.29045696079708 no 2397 0.309902065792635 3305 2888790
SGTC_2714 st079313 56.9 µM -0.496224894957186 0.290421045150969 no 2398 0.309867874302237 3285 2939799
SGTC_1904 st060225 78 µM -0.496407319971196 0.290353457995836 no 2399 0.309803530807764 3350 66595
SGTC_2678 equilin 100 µM -0.496632154668394 0.290270168492241 no 2400 0.309724236924344 3386 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_245 methotrexate 289.6 µM -0.500458949611286 0.288854260252234 no 2401 0.308375977024672 3333 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2433 5607874 27.82 µM -0.501930635460453 0.288310605561362 no 2402 0.307858157306112 3295 2252428
SGTC_1895 st058434 18.3 µM -0.503024263504823 0.287906921761017 no 2403 0.307473606634847 3414 5393175
SGTC_2930 9013230 14.89 µM -0.50310240440779 0.28787808833765 no 2404 0.307446138166178 3383 2995857
SGTC_1399 3562-5772 25 µM -0.504318025215496 0.287429708842934 no 2405 0.307018956398227 3307 23847490
SGTC_680 0417-1641 114 µM -0.504334535830544 0.287423621207244 no 2406 0.30701315619777 3224 2835990
SGTC_228 caffeine 993.056 µM -0.506572143804005 0.286599156577523 no 2407 0.306227528920991 3380 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_27 0485-0001 32.618 µM -0.507756184420789 0.286163341595821 no 2408 0.30581217050591 3334 2054479
SGTC_1623 st003709 20.3 µM -0.509628886492192 0.285474691371916 no 2409 0.305155741245359 3291 16192618
SGTC_691 1548-0686 185 µM -0.510240557262036 0.285249932258233 no 2410 0.304941470811902 3310 46495133
SGTC_11 0438-0307 1.3 µM -0.510722577910575 0.285072872649431 no 2411 0.304772664378055 3402 4011476
SGTC_303 1348-1668 34.2 µM -0.513582235043053 0.284023519890869 no 2412 0.303772051284589 3352 5380509
SGTC_2830 7992007 71.43 µM -0.514242903454525 0.283781350300298 no 2413 0.303541087607483 3304 1952075
SGTC_1691 st019933 84.6 µM -0.515417870154062 0.283350907864341 no 2414 0.303130523803684 3367 6176082
SGTC_1320 1313-0481 95.3 µM -0.515816934459058 0.283204784155522 no 2415 0.302991136923378 3450 6813365 YLR208W SEC13
SGTC_2062 5245942 200 µM -0.517380562946485 0.282632585430663 no 2416 0.302445262687818 3423 1376160
SGTC_896 0964-0007 44.5 µM -0.518522627607548 0.282215006435279 no 2417 0.30204683839133 3396 6756758
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.518676137192562 0.282158900580362 no 2418 0.30199330252572 3275 279621
SGTC_2240 6690706 185.951 µM -0.518730815867116 0.282138917497973 no 2419 0.301974234581921 3217 805876
SGTC_1029 k015-0030 64.7 µM -0.520164322886474 0.281615265637862 no 2420 0.301474524698143 3393 2208316
SGTC_1265 0819-1001 68.8 µM -0.52108882516887 0.281277799072125 no 2421 0.301152447602078 3417 3106768
SGTC_1289 0976-0073 69.1 µM -0.521263069872962 0.281214217249032 no 2422 0.301091761789636 3408 3391136
SGTC_666 0272-0154 136 µM -0.52135886705693 0.281179263851716 no 2423 0.301058399967605 3349 6870312
SGTC_1899 st063254 59.6 µM -0.521617386723219 0.281084948580379 no 2424 0.300968377588057 3283 3093813
SGTC_601 0986-0029 62.9 µM -0.521807821151924 0.281015482502367 no 2425 0.300902071788078 3369 24747981
SGTC_639 0833-0042 114 µM -0.522472218781097 0.28077319058078 no 2426 0.300670792235641 3310 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2207 7258803 200 µM -0.522563418017548 0.280739940013211 no 2427 0.300639051669364 3393 3666799
SGTC_2697 mebhydrolin 72.4 µM -0.523269159262365 0.280482696381396 no 2428 0.300393479863967 3442 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_543 3844-1095 191 µM -0.52515330326308 0.279796482803244 no 2429 0.299738311964566 3389 4230703
SGTC_514 4466-0038 2.65 nM -0.525635522427389 0.279620987438894 no 2430 0.299570735370676 3312 5722064
SGTC_165 k038-0023 64.381 µM -0.525691757707177 0.279600525056106 no 2431 0.299551195741873 3329 46368543
SGTC_904 1141-0088 396 µM -0.525780315258111 0.27956830301263 no 2432 0.299520426519702 3360 1378119
SGTC_1190 1486-1332 13 µM -0.528589864745257 0.278546973373544 no 2433 0.298544996329546 3379 4150046
SGTC_2838 9002687 71.43 µM -0.529826150356277 0.278098134381982 no 2434 0.298116236231062 3290 6457060
SGTC_2142 5622915 118.518 µM -0.530937461311904 0.277694969331319 no 2435 0.297731058588022 3378 5322196
SGTC_2543 pimpinellin 60.67 µM -0.531478124966737 0.277498928870878 no 2436 0.297543748030699 3283 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2670 beta-carotene 100 µM -0.533001715719344 0.276946850790741 no 2437 0.297016196316881 3399 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_928 2764-0428 58.7 µM -0.534468485788036 0.2764158704245 no 2438 0.296508723648563 3410 662578
SGTC_3009 9080819 71.4286 µM -0.535790971674932 0.27593755029661 no 2439 0.296051511275775 3389 17027216
SGTC_944 3370-0224 231 µM -0.536086139731363 0.275830848670734 no 2440 0.295949509392824 3359 4580514
SGTC_984 1492-0255 2.91 µM -0.538096943074551 0.275104494296314 no 2441 0.295255061396956 3387 1585198
SGTC_200 k038-0079 37.545 µM -0.539222888566082 0.274698185374341 no 2442 0.294866534431936 3339 3436683
SGTC_2199 6590217 200 µM -0.539770704968049 0.274500607303349 no 2443 0.294677586164755 3365 703109
SGTC_1615 st002656 86.5 µM -0.539781464515707 0.274496727415929 no 2444 0.294673875630499 3454 1584458
SGTC_1653 st012112 65 µM -0.540995978394439 0.27405894832795 no 2445 0.294255177329989 3454 720429
SGTC_1136 pergolide 1.05886 µM -0.541359450450267 0.273927999667442 no 2446 0.294129925390808 3315 47811 A dopamine receptor agonist.
SGTC_2404 5161160 200 µM -0.542861314031441 0.273387249021075 no 2447 0.29361264680991 3394 2831543
SGTC_1579 chlormadinone acetate 49.4 µM -0.546288946920392 0.272155102344934 no 2448 0.292433666419326 3463 45114258 A steroidal progestin.
SGTC_323 4013-0906 34.3 µM -0.546639569707165 0.272029218188269 no 2449 0.292313189181857 3441 2910086
SGTC_2271 7849410 118.62 µM -0.548322738111543 0.271425313385109 no 2450 0.291735158570327 3460 972430
SGTC_1997 st073024 93.8 µM -0.549843683165624 0.270880187855464 no 2451 0.291213296990429 3458 686268
SGTC_972 1319-0219 195 µM -0.550159437901596 0.27076708597785 no 2452 0.291105010937289 3403 23903702
SGTC_1191 1487-1166 10.6 µM -0.554589841112544 0.269182626548662 no 2453 0.289587619614418 3463 3955771
SGTC_1649 st011737 51.3 µM -0.554655224885 0.269159278014572 no 2454 0.289565253825975 3413 1761035
SGTC_486 niguldipine 82 µM -0.55494354080705 0.269056332567829 no 2455 0.289466639443557 3398 1236 A calcium channel blocker.
SGTC_840 0245-0196 390 µM -0.555522319080964 0.268849734941963 no 2456 0.289268724153429 3507 3827528
SGTC_3077 9117319 49.47 µM -0.555994531305528 0.268681235602622 no 2457 0.289107296631769 3453 17154678
SGTC_957 1187-1561 14.1 µM -0.556463374580747 0.268513990915377 no 2458 0.288947062722426 3443 1538454
SGTC_117 lucigenin 22.078 µM -0.556832650745313 0.268382300430009 no 2459 0.288820886725232 3446 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1039 k821-0043 94 µM -0.559262380390624 0.267516626128132 no 2460 0.287991332850742 3458 15992768
SGTC_1486 3970-0793 4.53 µM -0.560106194536801 0.267216318203058 no 2461 0.287703502726421 3473 2844330
SGTC_438 sphingosine 6.67 µM -0.560932445896496 0.266922425717248 no 2462 0.28742179516126 3296 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1025 k007-0731 70 µM -0.56166583534081 0.266661700493792 no 2463 0.287171857894968 3344 6256118
SGTC_1507 4075-3230 155 µM -0.561778119307364 0.266621794103778 no 2464 0.287133600887138 3405 659771
SGTC_2689 tacrolimus 100 µM -0.563563163759397 0.265987784520605 no 2465 0.28652573100608 3420 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_22 0964-0034 14.468 µM -0.564302435996259 0.265725434673229 no 2466 0.286274161934969 3438 138402
SGTC_366 0181-0206 4.31 µM -0.564507786564141 0.265652584008652 no 2467 0.286204301217697 3535 274874
SGTC_2464 5717415 7.67 µM -0.566072444737053 0.265097834869348 no 2468 0.285672267110152 3363 5285744
SGTC_79 0052-0007 94.094 µM -0.566233646481749 0.265040714286448 no 2469 0.285617480080338 3516 2801472
SGTC_1391 3442-0225 151 µM -0.567380692219478 0.264634448180366 no 2470 0.285227782408428 3412 5227075
SGTC_3332 9141069 11.198 µM -0.568879529673147 0.26410406060682 no 2471 0.284718949062819 3401 17332883
SGTC_2565 isoliquiritigenin 100 µM -0.570395742573662 0.263568076014361 no 2472 0.284204658256825 3436 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_1092 toremifene 6.32 µM -0.572177144794099 0.262939056343702 no 2473 0.283600984825677 3478 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.572467462904077 0.262836616728489 no 2474 0.283502661399933 3376 803109
SGTC_3307 9126885 69.2785 µM -0.575668049898216 0.261708634359236 no 2475 0.282419787511409 3413 24824909
SGTC_1604 st002052 72.4 µM -0.575701006516395 0.261697032396478 no 2476 0.282408647455818 3526 6254834 YHR062C RPP1
SGTC_781 4335-2806 94.4 µM -0.575872484648187 0.261636669937071 no 2477 0.282350687519146 3521 845254
SGTC_1279 0874-0590 65.2 µM -0.577020885480671 0.261232602644451 no 2478 0.281962673406059 3441 3523074
SGTC_326 k292-0812 17.5 µM -0.577486116117993 0.261069001554852 no 2479 0.281805557476836 3467 3579357
SGTC_1098 clofazimine 15.1 µM -0.577708347006952 0.260990871348762 no 2480 0.281730521396709 3523 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_643 k048-0106 28.4 µM -0.579072583177365 0.260511507394747 no 2481 0.281270099323606 3493 6763920
SGTC_1497 4476-2978 41.3 µM -0.579254619277306 0.260447578029891 no 2482 0.281208690640358 3499 1528379
SGTC_2438 5259590 200 µM -0.580044555366417 0.260170253543303 no 2483 0.280942285916738 3449 1201127
SGTC_1408 3909-7976 48.8 µM -0.5817267391747 0.259580193394442 no 2484 0.280375378822562 3490 24152374
SGTC_3141 9094609 49.47 µM -0.582379522793554 0.259351402509618 no 2485 0.280155535693767 3367 25236309 YDL196W YDL196W
SGTC_798 1287-0182 476 µM -0.58268203688558 0.25924541118947 no 2486 0.280053683949218 3539 1649755
SGTC_147 4466-0538 29.23 µM -0.583423135343221 0.258985848482708 no 2487 0.279804243606219 3580 6742687 YHR072W ERG7
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.583430653998968 0.258983215833753 no 2488 0.27980171351499 3577 6710655
SGTC_1825 st052143 62.6 µM -0.584807070816568 0.258501498324773 no 2489 0.279338724705387 3534 674173
SGTC_3288 9119690 36.221 µM -0.585164737439132 0.258376398389083 no 2490 0.279218476433254 3443 17595618 YKL019W RAM2
SGTC_1774 st048371 48.465 µM -0.585987184237542 0.25808885278788 no 2491 0.278942063566206 3431 4242727
SGTC_1661 st013063 9.66 µM -0.587295312535952 0.257631844296145 no 2492 0.278502694368119 3504 721395
SGTC_3012 9080433 71.4286 µM -0.589851982365007 0.25673985928727 no 2493 0.27764494438491 3512 17688859
SGTC_1772 st048439 82.2 µM -0.590346889730235 0.256567379205535 no 2494 0.27747905463807 3475 2927068 YDL195W SEC31
SGTC_2150 5556613 200 µM -0.592761198936838 0.255726834859482 no 2495 0.276670489131904 3475 743190
SGTC_2144 5628481 200 µM -0.593110356511654 0.255605394382658 no 2496 0.276553649962423 3477 2818399
SGTC_293 4049-0273 38.5 µM -0.593228993936867 0.255564137963357 no 2497 0.276513955633481 3442 1380311
SGTC_432 NS 1619 61.3 µM -0.593647172950557 0.255418743057415 no 2498 0.276374061396651 3517 4552 A K+/calcium channel activator.
SGTC_1375 2910-0797 186 µM -0.593728926383124 0.25539032360179 no 2499 0.276346716319616 3445 742508
SGTC_1982 st072467 71.9 µM -0.593989683730719 0.255299689131063 no 2500 0.276259506468152 3401 3163533
SGTC_755 1995-0008 37.3 µM -0.594630226846647 0.255077119496751 no 2501 0.27604533526083 3523 689533
SGTC_1343 1487-0095 224 µM -0.594750128548794 0.255035468510735 no 2502 0.276005254136 3514 4560101 YGL055W OLE1
SGTC_296 1222-0039 74.9 µM -0.594820089067728 0.255011167542073 no 2503 0.275981868830114 3466 5984176
SGTC_2383 9036125 200 µM -0.59489927810234 0.254983662486167 no 2504 0.275955399934785 3456 79580
SGTC_839 0122-0028 230 µM -0.5967706705636 0.254334116025522 no 2505 0.2753302510864 3456 759448
SGTC_286 k060-0067 22.9 µM -0.597331347355149 0.25413967826139 no 2506 0.275143089729659 3461 5985051
SGTC_439 amiodarone 34.4 µM -0.597474971094264 0.254089883362318 no 2507 0.275095156300487 3428 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_807 1315-0151 48 µM -0.597506216052633 0.254079051293714 no 2508 0.275084729056521 3577 4011080
SGTC_654 1124-0271 80.9 µM -0.597767029370639 0.253988641429305 no 2509 0.274997696558159 3480 5403748
SGTC_1836 st055642 81 µM -0.599474442122655 0.253397191042111 no 2510 0.274428274171985 3433 8571
SGTC_1106 tegaserod maleate 11.7 µM -0.600401785833726 0.253076261375664 no 2511 0.274119248965407 3476 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2832 7992762 51.95 µM -0.602772640807732 0.252256742955551 no 2512 0.273329974877211 3336 2985177
SGTC_173 1273-0061 2.693 µM -0.605207829421598 0.251416445770307 no 2513 0.272520457127368 3478 2847414 YPL266W DIM1
SGTC_1225 1216-0074 20.6 µM -0.605332315068215 0.251373529972927 no 2514 0.272479106981164 3473 4241466
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.605360722886011 0.25136373706403 no 2515 0.272469671250246 3459 6857784
SGTC_2497 7-hydroxyflavone 100 µM -0.605808382898459 0.251209443722126 no 2516 0.272321001236115 3537 5281894
SGTC_2031 5180455 200 µM -0.60641260822813 0.251001267035673 no 2517 0.272120399068428 3512 29949
SGTC_770 0389-1121 67.2 µM -0.606652447626661 0.250918659319384 no 2518 0.272040793014994 3595 6753108
SGTC_3219 9131112 49.47 µM -0.6080569428124 0.250435199026001 no 2519 0.271574853993305 3478 17612988 YMR079W SEC14
SGTC_3186 9110464 49.47 µM -0.608687184695071 0.250218415520423 no 2520 0.271365901513065 3551 17018021
SGTC_1336 1486-0901 104 µM -0.609691051622458 0.249873322279141 no 2521 0.27103324166236 3490 5006114
SGTC_1022 4477-0945 21.3 µM -0.60996364620751 0.249779657727672 no 2522 0.270942944826266 3513 4648966
SGTC_599 1935-0052 86.5 µM -0.610638455535847 0.249547870855712 no 2523 0.270719479124421 3498 9557311
SGTC_2895 9054447 58.44 µM -0.610847280927862 0.249476165629975 no 2524 0.270650344443606 3535 2697450
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.611922264220524 0.249107217556128 no 2525 0.270294595180599 3493 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1558 st069300 45.6 µM -0.613516851747471 0.248560469686571 no 2526 0.269767321806626 3513 24208000
SGTC_20 0481-0013 4.944 µM -0.614134830733424 0.248348750741812 no 2527 0.26956311671728 3517 182045
SGTC_2926 9010726 65.15 µM -0.615798070679549 0.247779404381478 no 2528 0.269013900456673 3523 2994293
SGTC_598 3937-0236 20.2 µM -0.616161761298957 0.2476550017733 no 2529 0.26889388153698 3552 1379313
SGTC_1709 st033179 39.1045 µM -0.617230524435866 0.24728961792136 no 2530 0.268541342385889 3532 573381
SGTC_1633 st005664 67.9 µM -0.618247085531207 0.246942348280387 no 2531 0.268206238175423 3526 2063822
SGTC_2072 5231554 129 µM -0.618627471305204 0.246812470999934 no 2532 0.268080900053366 3618 789545
SGTC_1114 scopoletin 1.73284 µM -0.618715865941364 0.246782295153049 no 2533 0.268051778008564 3566 5280460 A coumarin with genotoxic properties.
SGTC_499 genistein 192 µM -0.619228372308806 0.246607376482047 no 2534 0.267882961672835 3551 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_591 4299-0174 154 µM -0.621297820787884 0.245901748693594 no 2535 0.267201843637191 3477 5509088
SGTC_13 0199-0087 65 µM -0.622507984489434 0.245489617168447 no 2536 0.266803947607512 3564 4589825
SGTC_1798 st045719 60.953 µM -0.623028030584758 0.245312625127608 no 2537 0.266633050969651 3505 3980186
SGTC_792 4534-1957 155 µM -0.623854932699839 0.245031339276424 no 2538 0.266361429854715 3497 1717904
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.624072449554249 0.244957375780996 no 2539 0.26629000310388 3573 279621
SGTC_1381 2324-0066 62.1 µM -0.62478333492218 0.24471573318531 no 2540 0.266056634884246 3538 10885928
SGTC_2218 6965428 192.983 µM -0.625075092137544 0.244616596870555 no 2541 0.265960887318391 3537 675684
SGTC_3338 9144300 39.5675 µM -0.625276074730729 0.24454831748891 no 2542 0.265894939914476 3508 4901274
SGTC_510 ag-490 170 µM -0.626331588607118 0.24418989863505 no 2543 0.265548735555135 3645 5328779
SGTC_3246 9135460 32.98 µM -0.626531171610518 0.244122158466975 no 2544 0.265483298837298 3500 41446951
SGTC_2593 nobiletin 86.24 µM -0.627498590272852 0.243793952006954 no 2545 0.26516622998052 3501 72344 An anti-infammatory.
SGTC_1763 st044482 94.5 µM -0.627580951434112 0.243766021164544 no 2546 0.265139245217706 3544 88505
SGTC_2896 9052656 71.43 µM -0.628944590079732 0.243303826482362 no 2547 0.264692666249091 3536 6469436
SGTC_653 0203-0016 55.2 µM -0.629288884056473 0.243187205659029 no 2548 0.264579973688814 3539 295302
SGTC_2415 st077333 57.7 µM -0.629802990207035 0.243013121553741 no 2549 0.264411744515044 3632 2766255
SGTC_3173 9105693 49.47 µM -0.630371551035662 0.242820676791592 no 2550 0.264225759746595 3625 17096658
SGTC_533 1222-0222 6.71 µM -0.630981137492437 0.242614437448618 no 2551 0.264026428914056 3610 3982874
SGTC_1732 st034308 51.822 µM -0.631155389509385 0.242555500784265 no 2552 0.263969463716393 3502 830119
SGTC_1031 k035-0009 16 µM -0.631507989377271 0.242436265857977 no 2553 0.263854213505943 3589 5180959
SGTC_3244 9134489 49.47 µM -0.631683282847313 0.24237700055894 no 2554 0.263796926920619 3532 16584271
SGTC_1550 gossypolone 36.6 µM -0.631836544079549 0.242325190613219 no 2555 0.263746845753192 3580 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2892 9047358 58.44 µM -0.631963100164279 0.242282412864549 no 2556 0.263705494681395 3526 6466771
SGTC_2769 toremifene 3.73 µM -0.632330313474601 0.242158312735333 no 2557 0.263585529728587 3599 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2688 kanamycin b 96.69 µM -0.634488316510291 0.241429710140151 no 2558 0.262881094615939 3685 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1059 3448-6867 171 µM -0.635536121521028 0.241076371593742 no 2559 0.262539408006784 3568 3934407
SGTC_1255 0566-0045 221 µM -0.636758579660337 0.240664492521305 no 2560 0.26214105495264 3599 2788469
SGTC_1741 st038134 10.228 µM -0.637545857085257 0.240399440457739 no 2561 0.261884674964533 3643 1272587
SGTC_344 k064-0035 6.43 µM -0.638524757939204 0.240070096575146 no 2562 0.261566071497047 3526 5088750
SGTC_827 3253-0474 693 µM -0.641703028588326 0.239002488998735 no 2563 0.260533011211591 3595 5402065
SGTC_990 3985-0011 41.3 µM -0.641855225162871 0.238951430109404 no 2564 0.260483594227071 3544 5399565 YGL099W LSG1
SGTC_1056 3448-1962 115 µM -0.642069229297234 0.238879646117628 no 2565 0.260414116998713 3569 715507
SGTC_596 1155-0152 116 µM -0.642554176751025 0.238717022520304 no 2566 0.260256712354478 3597 280313
SGTC_3212 9128307 49.47 µM -0.643018375771862 0.238561413517798 no 2567 0.260106088191455 3475 27243542
SGTC_2480 5767542 37.17 µM -0.646939004275795 0.237249356032609 no 2568 0.258835710423843 3591 2867358
SGTC_864 0469-0573 172 µM -0.647362920529592 0.237107728218355 no 2569 0.258698543967313 3529 689425
SGTC_2147 5545932 89.7195 µM -0.648350291578114 0.236778033803497 no 2570 0.258379206556901 3587 797404
SGTC_907 3448-6986 75.5 µM -0.648708584926905 0.236658457952889 no 2571 0.258263377169696 3641 590582
SGTC_3270 9137563 49.47 µM -0.649157461876666 0.236508697867771 no 2572 0.258118301825342 3532 17015724
SGTC_2793 7325131 81.82 µM -0.65032478936535 0.236119483382414 no 2573 0.257741223891876 3559 4176441
SGTC_2429 5902844 64.44 µM -0.651178488781966 0.235835063418216 no 2574 0.25746563733451 3601 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_3324 9138759 60.749 µM -0.651773242349837 0.235637025979411 no 2575 0.25727373276691 3598 45595710
SGTC_1950 st077106 7.18 µM -0.651809449965932 0.235624972749595 no 2576 0.257262052334789 3559 13831864
SGTC_110 0850-0284 111.64 µM -0.653949048069439 0.234913321556108 no 2577 0.256572316284401 3488 3906265
SGTC_1569 carminic acid 40.6 µM -0.65428804486968 0.23480067702033 no 2578 0.256463123323987 3613 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_3192 9110362 49.47 µM -0.655492471636484 0.234400702173854 no 2579 0.256075365946748 3665 16649480
SGTC_3199 9111318 49.47 µM -0.655781893101621 0.234304645192877 no 2580 0.255982234175078 3570 8548020
SGTC_705 1124-0212 310 µM -0.656451472737641 0.234082499879687 no 2581 0.255766840583738 3608 9554485
SGTC_552 k242-0005 476 µM -0.656571830119581 0.234042581484149 no 2582 0.255728133478083 3625 4088318
SGTC_3196 9111891 49.47 µM -0.657805230957356 0.233633722305495 no 2583 0.255331646344628 3613 18891510
SGTC_1711 st032263 62.8 µM -0.6585016439614 0.233403043891048 no 2584 0.255107920507087 3603 3958979
SGTC_3046 9092212 49.47 µM -0.659034652123473 0.233226576759414 no 2585 0.254936758509704 3623 25236637
SGTC_1187 1391-0724 117 µM -0.659050431297212 0.233221353755243 no 2586 0.254931692345907 3641 6997986
SGTC_2645 abamectin 100 µM -0.659058627257326 0.233218640867336 no 2587 0.254929060918618 3600 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1304 1165-0502 251 µM -0.659498944103384 0.233072920392737 no 2588 0.254787711951614 3596 767425
SGTC_451 chloral hydrate 100 µM -0.659950648871347 0.232923483696076 no 2589 0.254642749920079 3660 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3282 9108498 15.4605 µM -0.663067574918585 0.231893768508604 no 2590 0.253643638163902 3580 16459645
SGTC_1527 coumarin 137 µM -0.66553092790123 0.231081766173066 no 2591 0.252855484339231 3644 323 A hepatotoxic, DNA x-linker.
SGTC_2013 4024628 200 µM -0.666007158286275 0.230924968188926 no 2592 0.252703262489951 3636 5230760
SGTC_803 4488-1585 147 µM -0.667727500876095 0.230359043700969 no 2593 0.252153776042132 3591 747204
SGTC_2037 5169046 200 µM -0.668530436527822 0.230095175374845 no 2594 0.251897530055498 3631 5718022
SGTC_727 3032-0951 202 µM -0.669494757554116 0.22977849469223 no 2595 0.251589961879912 3603 3652836
SGTC_391 gliotoxin 8.33 µM -0.66976573620994 0.22968954990622 no 2596 0.251503569524893 3663 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_3255 9139072 49.47 µM -0.671527996410119 0.229111584452002 no 2597 0.25094211529619 3648 17646060
SGTC_645 0845-0943 5.41 µM -0.673425631175668 0.228490133616534 no 2598 0.250338273412619 3609 1885106
SGTC_2521 angolensin 13.4 µM -0.673792881923782 0.228369973210552 no 2599 0.250221500445164 3650 821428 A flavenoid.
SGTC_1539 benzyladenosine 56 µM -0.674220479737578 0.228230112662239 no 2600 0.250085575613288 3619 92208 A nucleotide analog.
SGTC_1319 1306-0155 43.7 µM -0.674379577623386 0.228178086528976 no 2601 0.250035011563327 3668 3122360
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.674490759476595 0.228141733235415 no 2602 0.249999679274407 3640 16486 A toxic proline analog.
SGTC_2966 9084041 48.03 µM -0.678915590247593 0.226697586341933 no 2603 0.248595673434566 3576 17741380
SGTC_1822 st052468 42 µM -0.680525846033546 0.226173324812928 no 2604 0.248085781097337 3642 2873678
SGTC_2079 5212404 121 µM -0.681016819946279 0.22601361161388 no 2605 0.247930423793051 3645 758462
SGTC_2800 7887935 81.82 µM -0.681780341658443 0.225765365668949 no 2606 0.247688928253597 3630 2961002
SGTC_1400 3771-8998 51.5 µM -0.682280164171754 0.225602940545159 no 2607 0.247530906628667 3597 670767
SGTC_508 roscovitine 141 µM -0.683434468338905 0.225228084205645 no 2608 0.247166172975919 3680 160355 A CDKinase inhibitor.
SGTC_2303 7774051 200 µM -0.683560184200939 0.225187279722641 no 2609 0.247126467009415 3642 2953184
SGTC_903 1134-0042 114 µM -0.683808088756513 0.225106827866531 no 2610 0.247048179091838 3646 701009
SGTC_3138 9097216 49.47 µM -0.688111236103644 0.223712935275164 no 2611 0.245691367641548 3667 25237486
SGTC_1390 3413-2614 145 µM -0.689327239328138 0.223319933782804 no 2612 0.245308680017092 3675 3421432
SGTC_308 4092-1169 104 µM -0.689798697432067 0.22316766845153 no 2613 0.245160393969946 3627 2268590 YDL196W YDL196W
SGTC_1077 5-fluorocytosine 377 nM -0.690025836570488 0.223094331145364 no 2614 0.245088969911052 3649 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3083 9117465 49.47 µM -0.691471348608609 0.222627934672425 no 2615 0.244634690022993 3645 16420915
SGTC_1157 4092-0394 27.6 µM -0.694138114251791 0.221768959297137 no 2616 0.243797799083879 3754 3659885
SGTC_2137 5261020 140 µM -0.694895669111494 0.221525293746438 no 2617 0.24356034350853 3650 763655
SGTC_1293 1000-1278 195 µM -0.697699515450093 0.220624776404966 no 2618 0.242682565630436 3703 678847
SGTC_1335 1486-0900 202 µM -0.699688075722853 0.219987379331385 no 2619 0.242061062438172 3694 X1335
SGTC_2270 7924575 90.91 µM -0.701811927918334 0.219307785187415 no 2620 0.241398229565667 3670 1262135
SGTC_733 4069-0007 56.1 µM -0.701828435260247 0.219302507867446 no 2621 0.241393081655037 3709 5717425 YNL287W SEC21
SGTC_3047 9092122 49.47 µM -0.704393178599865 0.218483458433684 no 2622 0.240593976444496 3650 17173831
SGTC_2733 amorolfine 100 µM -0.708560826329197 0.217156286367037 no 2623 0.239298526593975 3699 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2337 9009472 200 µM -0.710230836805946 0.216625787511371 no 2624 0.238780500629724 3707 5742383
SGTC_2833 9001315 45.46 µM -0.710408662098291 0.216569343370601 no 2625 0.238725376587581 3684 2989378
SGTC_2663 amphotericin b 100 µM -0.711832452592156 0.216117719997509 no 2626 0.238284267081577 3686 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_707 0865-0008 204 µM -0.712473871049248 0.215914441744172 no 2627 0.238085692956102 3687 723043
SGTC_1061 3448-9325 110 µM -0.712833474231854 0.21580052483505 no 2628 0.237974404560719 3645 723482
SGTC_1129 3453-1384 223 µM -0.713202594976544 0.215683629143146 no 2629 0.237860200378656 3787 1084452
SGTC_1704 st028805 70.8 µM -0.713936951311504 0.215451177336074 no 2630 0.237633083464329 3716 2876101
SGTC_1572 epiandrosterone 68.9 µM -0.717642625907406 0.214280408937943 no 2631 0.2364888339268 3647 441302 A steroid.
SGTC_3181 9108277 49.47 µM -0.718627551935276 0.213969855716871 no 2632 0.23618521633617 3665 17097298
SGTC_227 fluconazole 33.516 µM -0.719490077902432 0.213698111300264 no 2633 0.235919506753606 3693 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_766 1391-0721 126 µM -0.721238242049225 0.213147957874624 no 2634 0.235381473374415 3699 1020919 YIL115C NUP159
SGTC_3300 9124615 50.48 µM -0.72142693589658 0.213088624691704 no 2635 0.235323439495425 3726 24824903
SGTC_934 2950-0684 338 µM -0.721807630980532 0.212968947677724 no 2636 0.235206378577872 3721 1121253
SGTC_3026 9090633 49.47 µM -0.722511427473222 0.212747802362018 no 2637 0.234990051068685 3721 25236842
SGTC_2134 5324836 1.464 µM -0.72262142285399 0.212713251984269 no 2638 0.234956251477103 3692 699272
SGTC_3239 9133757 49.47 µM -0.722645077143841 0.212705822421659 no 2639 0.234948983292516 3707 17036923
SGTC_114 0364-0001 490.298 µM -0.722710717790871 0.212685206181335 no 2640 0.23492881473328 3738 4003655
SGTC_3273 9137859 49.47 µM -0.725994179550514 0.211655434973151 no 2641 0.233921169356809 3783 2377234
SGTC_3268 9137683 49.47 µM -0.726504237344083 0.2114957310889 no 2642 0.233764855397364 3733 1953228
SGTC_521 r062-0005 13.8 µM -0.72681960914795 0.21139702052775 no 2643 0.233668234508177 3639 2832033
SGTC_1066 ketoconazole 628 nM -0.729210471210989 0.210649565002336 no 2644 0.232936463465934 3762 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_58 0957-0393 9 µM -0.731147141300518 0.210045241876458 no 2645 0.232344641309773 3660 6997992
SGTC_3092 9117248 49.47 µM -0.733110745074971 0.209433555516336 no 2646 0.231745443532971 3792 17141857
SGTC_1636 st007707 68.9 µM -0.733977756072896 0.209163804991496 no 2647 0.231481147574437 3738 403051
SGTC_88 0180-0332 8.668 µM -0.735984177208157 0.208540338201787 no 2648 0.230870163579897 3792 3101745
SGTC_2553 4-methylesculetin 85.09 µM -0.736800934838021 0.20828685653549 no 2649 0.230621707311446 3787 5319502
SGTC_1075 aripiprazole 15.2 µM -0.737218180421007 0.208157434069315 no 2650 0.230494839600695 3757 60795 An atypical antipschotic. YIL048W NEO1
SGTC_3206 9114350 49.47 µM -0.738678234799712 0.207704923838775 no 2651 0.230051202624204 3675 17087243
SGTC_335 4077-0256 27.6 µM -0.739078446913908 0.207580988862121 no 2652 0.229929681810475 3747 3121989
SGTC_1954 st077032 68.9 µM -0.739719761896945 0.207382481925507 no 2653 0.229735027217345 3645 698907
SGTC_2845 9003024 42.97 µM -0.739786332542438 0.207361882671238 no 2654 0.2297148267063 3747 2990173
SGTC_2536 dehydroabietamide 32.04 µM -0.739875283408685 0.207334360092788 no 2655 0.229687836588083 3741 3983547
SGTC_1244 0416-0015 52.5 µM -0.739976607692553 0.20730301164631 no 2656 0.229657094201617 3745 96201
SGTC_3216 9129716 49.47 µM -0.740047620042353 0.207281042997746 no 2657 0.229635550008806 3721 8056934
SGTC_738 1315-0003 72.4 µM -0.74170426624993 0.206768927464366 no 2658 0.229133267205414 3737 6251474
SGTC_1643 st009866 20.2 µM -0.741789667135357 0.206742547988142 no 2659 0.229107391004721 3724 3156273 YOR207C RET1
SGTC_1657 st012939 43.4 µM -0.742217909262489 0.206610298345024 no 2660 0.228977659702465 3748 24207257
SGTC_2690 usnic acid 100 µM -0.742253349410325 0.206599355971294 no 2661 0.228966925341523 3766 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_585 0kpi-0023 191 µM -0.743348568255384 0.206261369333546 no 2662 0.228635336990529 3680 64601
SGTC_1481 3346-2004 36 µM -0.743700756978885 0.206152752896594 no 2663 0.228528765697345 3756 2770522
SGTC_1413 3910-0535 34.4 µM -0.745731423605745 0.205527148781548 no 2664 0.227914836401332 3751 2876951
SGTC_2191 5911152 200 µM -0.746672873647533 0.205237491394857 no 2665 0.227630523922337 3755 2875902
SGTC_3348 9149464 3.537 µM -0.748764175900909 0.204594925616846 no 2666 0.226999677699485 3736 1951442
SGTC_1990 st072050 59.8 µM -0.749645510425584 0.204324488954375 no 2667 0.226734116646726 3757 17233948
SGTC_1213 1315-0166 115 µM -0.750540244164727 0.204050158575785 no 2668 0.226464697598989 3807 768401
SGTC_1282 0886-0010 32.4 µM -0.750652095582852 0.204015879740698 no 2669 0.226431030013212 3825 2836211 YNL267W PIK1
SGTC_897 1000-0139 31.4 µM -0.75402375366561 0.202984187106407 no 2670 0.225417479302527 3727 6151020
SGTC_835 0312-0010 67.2 µM -0.756417260648701 0.202253693198057 no 2671 0.224699531201765 3728 1626196
SGTC_306 1672-3436 11.6 µM -0.759344832507989 0.2013623449582 no 2672 0.223823152666143 3773 6797378
SGTC_3258 9138477 49.47 µM -0.759687908966561 0.201258043942185 no 2673 0.223720578896902 3815 4970355
SGTC_1055 3448-0672 86 µM -0.759866542784526 0.201203749081387 no 2674 0.223667181139409 3778 748378
SGTC_2673 kobusone 100 µM -0.760635976710085 0.200969983872842 no 2675 0.223437262489506 3805 6710676 An epoxy ketone and protein crosslinker.
SGTC_728 3030-5151 22.5 µM -0.76224951335662 0.200480297404396 no 2676 0.222955549914912 3799 3125388
SGTC_2177 5811945 192 µM -0.762366904333572 0.200444698823046 no 2677 0.222920526577901 3800 5343475
SGTC_677 0929-0063 136 µM -0.764799772566959 0.199707791350006 no 2678 0.222195391617487 3741 1539583
SGTC_1441 4106-0040 13 µM -0.765708999545383 0.199432808537432 no 2679 0.221924735499149 3769 2904180
SGTC_359 0081-0058 15.9 µM -0.768912860959071 0.198465664276414 no 2680 0.220972521010928 3807 3494159
SGTC_2618 avocadyne 43.43 µM -0.769256684247372 0.198362043309258 no 2681 0.220870472979414 3720 3015189
SGTC_2451 5856223 45.7 µM -0.77006446720951 0.198118723333109 no 2682 0.220630826181017 3764 2179896
SGTC_2949 9072542 2.23 µM -0.770722829328677 0.197920545180806 no 2683 0.220435618624316 3857 16457352
SGTC_1839 st053978 48 µM -0.770744643996773 0.197913980646366 no 2684 0.220429152164354 3812 3788398
SGTC_2558 carylophyllene oxide 100 µM -0.771411867838833 0.197713261210831 no 2685 0.220231421424432 3874 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_2396 5342950 42.78 µM -0.771452904068886 0.197700920391817 no 2686 0.220219263722898 3808 1886677
SGTC_1364 1653-0028 37.6 µM -0.771591610230391 0.19765921075582 no 2687 0.220178172443478 3792 5718652
SGTC_1865 st057639 52.2 µM -0.772543896116218 0.197372997257089 no 2688 0.219896179391084 3785 688818
SGTC_2922 7999257 32.47 µM -0.772648252198607 0.197341647846716 no 2689 0.219865289837968 3762 2988377
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.776576135809581 0.196163870974937 no 2690 0.21870444280026 3754 97141
SGTC_199 4063-0024 41.6 µM -0.776764435083803 0.196107516669284 no 2691 0.218648881568844 3817 306215
SGTC_1509 1326-1131 80 µM -0.777700462137621 0.19582752774785 no 2692 0.218372809847344 3719 768313
SGTC_983 1491-0821 12.2 µM -0.777906005608728 0.195766077095057 no 2693 0.218312213774854 3786 46495113
SGTC_2533 agelasine 13.65 µM -0.779332874327133 0.195339813582955 no 2694 0.217891827104193 3829 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_95 0471-0001 561.058 µM -0.780274372914869 0.195058858829074 no 2695 0.217614696897863 3741 4015405
SGTC_23 0213-0011 39.996 µM -0.780292432793468 0.195053471941591 no 2696 0.217609382959766 3815 627608
SGTC_1488 4013-0813 75.9 µM -0.780997684866365 0.194843180593731 no 2697 0.21740192817859 3757 2910057
SGTC_1278 0874-0585 172 µM -0.781085377079974 0.194817042260425 no 2698 0.217376140891007 3861 766306
SGTC_3079 9117512 49.47 µM -0.78257203259024 0.194374240915734 no 2699 0.216939235086665 3826 7185044
SGTC_1762 st045503 25.4615 µM -0.786003202030197 0.193354606430628 no 2700 0.21593280561345 3885 4645554
SGTC_1328 1441-0025 69.2 µM -0.786323502087751 0.19325959027753 no 2701 0.215838993565249 3763 4562601
SGTC_2611 pyromycin 23.93 µM -0.786879798708209 0.193094634117646 no 2702 0.215676117100955 3822 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_416 estradiol valerate 100 µM -0.787583795535536 0.192886004342997 no 2703 0.215470098109256 3846 13791 A steroid.
SGTC_646 4092-0839 27.3 µM -0.788768227708504 0.192535308177545 no 2704 0.215123741297408 3850 877796
SGTC_1829 berberine 14.4 µM -0.78960633751974 0.192287389548426 no 2705 0.214878852969103 3845 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2441 5730946 39.09 µM -0.791686835072708 0.191672808546746 no 2706 0.214271650228719 3903 1774275
SGTC_2055 5235184 200 µM -0.791920097947947 0.191603977546988 no 2707 0.214203633673226 3852 2836034
SGTC_1524 corynanthine 62.1 µM -0.792672622442142 0.191382026523576 no 2708 0.213984292531337 3941 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1790 st045711 43.5 µM -0.794297561812838 0.19090330149968 no 2709 0.213511111562133 3801 585119
SGTC_663 1486-0733 13.9 µM -0.794758066986353 0.190767765316092 no 2710 0.213377123818572 3836 722445 YPR165W RHO1
SGTC_1758 st042942 75.2445 µM -0.795473345507148 0.190557361199185 no 2711 0.213169104912071 3754 669317
SGTC_374 0880-0231 82.3 µM -0.797928897630698 0.189836128306885 no 2712 0.212455876338566 3771 6833587
SGTC_2823 7987624 58.44 µM -0.799770034119697 0.189296461214638 no 2713 0.211922023884187 3816 2239440
SGTC_1778 st046819 58.9 µM -0.799977790184495 0.189235623883372 no 2714 0.211861832636496 3881 671715
SGTC_2179 6298986 200 µM -0.800603692648962 0.189052413270569 no 2715 0.211680556156983 3756 738374
SGTC_2817 7995342 71.43 µM -0.801594336111233 0.188762661138865 no 2716 0.211393827497672 3832 18879975
SGTC_2587 piperic acid 92.2 µM -0.801736564207996 0.188721083491692 no 2717 0.21135268013627 3853 5370536
SGTC_3164 9100705 49.47 µM -0.802264520177626 0.188566795096716 no 2718 0.211199980639422 3841 17174235
SGTC_2334 9017922 200 µM -0.802299529094812 0.188556566937756 no 2719 0.211189857376358 3895 3163164
SGTC_1192 1488-0095 21.4 µM -0.803262658357829 0.188275314537602 no 2720 0.210911468118306 3885 915875
SGTC_1877 wortmannin 25 µM -0.804419290398048 0.187937897835321 no 2721 0.210577432062575 3837 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2033 5192550 145 µM -0.805717956623697 0.187559491677819 no 2722 0.210202746664915 3839 182073
SGTC_2093 5331342 194.4 µM -0.805874774218527 0.187513829950167 no 2723 0.210157528861565 3879 33839
SGTC_2598 perillyl alcohol 100 µM -0.808874276501311 0.186641765711894 no 2724 0.209293733256737 3872 10819 An apoptosis inducer.
SGTC_3309 9129340 25.759 µM -0.8100081864809 0.186312752012153 no 2725 0.208967735339415 3882 17158987
SGTC_607 4491-0986 66.8 µM -0.81143489123778 0.185899292263611 no 2726 0.208557984433204 3849 698981 YDR232W HEM1
SGTC_2720 fluspirilene 36.88 µM -0.81243836685865 0.185608825644457 no 2727 0.208270069293894 3828 3396 An atypical antipsychotic.
SGTC_222 nsc-310342 10.666 µM -0.813303770747332 0.185358551640379 no 2728 0.20802195783152 3793 432556
SGTC_1846 st056244 14.8 µM -0.813859446490204 0.185197961238343 no 2729 0.207862737516312 3878 5393182
SGTC_313 3474-0040 5.03 µM -0.814412084282683 0.185038334533756 no 2730 0.207704459079447 3840 1043375 YIL048W NEO1
SGTC_3088 9117578 49.47 µM -0.817077605271074 0.184269612927495 no 2731 0.206942040019327 3902 678341
SGTC_2979 9012552 45.46 µM -0.817625875285466 0.184111741639105 no 2732 0.206785423945391 3892 17100905
SGTC_3193 9111931 49.47 µM -0.817963237524377 0.184014641922013 no 2733 0.206689089615627 3884 17087244
SGTC_1261 0712-0010 12.7 µM -0.819664243649258 0.183525543565972 no 2734 0.206203769527232 3843 2840123
SGTC_1999 st074831 12.5 µM -0.821474020203226 0.183006060445715 no 2735 0.205688158201021 3846 17112523
SGTC_186 3455-3465 67.277 µM -0.825886235506539 0.181743416217813 no 2736 0.204434314706846 3815 755278
SGTC_2736 butenafine 14.65 µM -0.826492064190383 0.181570472683353 no 2737 0.204262508961259 3817 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3019 9081971 49.47 µM -0.828227666222872 0.181075587628503 no 2738 0.203770789241488 3885 16451803
SGTC_1149 3909-7961 23.3 µM -0.828873349513084 0.180891695044783 no 2739 0.203588038599777 3901 735261
SGTC_1699 st031318 29.054 µM -0.829118887392468 0.180821795831641 no 2740 0.203518568571344 3931 5340658
SGTC_1280 0880-0253 10.1 µM -0.829403247509442 0.180740865945659 no 2741 0.203438132239786 3855 6836607
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.829717820212539 0.180651363912385 no 2742 0.203349171838115 3904 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2294 7971431 200 µM -0.831482108992469 0.180149904731946 no 2743 0.202850665548408 3849 5741572
SGTC_60 0986-0278 202 µM -0.832668863322513 0.179813088691646 no 2744 0.202515754808765 3793 3110598
SGTC_1415 3966-0071 78.1 µM -0.836540622408337 0.178716986827459 no 2745 0.201425416866712 3821 2893185
SGTC_2589 lobaric acid 100 µM -0.840549141627325 0.177586610287136 no 2746 0.200300280312823 3917 73157 A novel microtubule depolymerizer.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.840926000512621 0.17748057104812 no 2747 0.200194695721917 3921 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_232 clozapine 119 µM -0.841339897488463 0.177364156223504 no 2748 0.200078772714915 3836 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3153 9100258 49.47 µM -0.842459467773385 0.177049501691804 no 2749 0.199765409129771 3816 25236848
SGTC_2096 5468907 200 µM -0.842776821797761 0.176960373733838 no 2750 0.199676636645205 3938 759785
SGTC_2852 9023854 51.95 µM -0.842822878327554 0.17694744124725 no 2751 0.199663755363543 3980 19798528
SGTC_1150 3909-7983 10.9 µM -0.843340912582583 0.176802020472446 no 2752 0.199518903832819 3875 23965914
SGTC_3006 9075424 71.4286 µM -0.844448430054675 0.176491375506544 no 2753 0.199209434617324 3853 7465181
SGTC_1420 4'-methoxyflavone 42 µM -0.844669578959706 0.176429387347424 no 2754 0.199147674502604 3853 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_651 3253-0966 34.4 µM -0.846643017892166 0.175876841295036 no 2755 0.198597064321268 3921 781462
SGTC_2824 7998404 51.95 µM -0.849082145708818 0.175195422526372 no 2756 0.197917792264178 3868 837851
SGTC_2774 tamoxifen 10.92 µM -0.850463213763576 0.174810337212461 no 2757 0.197533802048359 3918 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_3178 9107506 49.47 µM -0.850516810735736 0.174795403524427 no 2758 0.197518909106303 3944 8897194
SGTC_187 1488-2104 32.728 µM -0.850653608901531 0.174757291215394 no 2759 0.197480900201691 3904 2852859
SGTC_1512 0259-0544 12.2 µM -0.850936760496773 0.174678421238083 no 2760 0.197402241546595 3852 18476
SGTC_809 3998-0021 90 µM -0.852498815271687 0.174243727676436 no 2761 0.196968648141338 3872 715485
SGTC_3171 9103192 49.47 µM -0.853393105519221 0.173995171451759 no 2762 0.196720671777084 3934 13018434
SGTC_1178 0988-0033 191 µM -0.853744036427239 0.173897696434102 no 2763 0.196623414367221 3968 5392207
SGTC_2557 derrustone 83.84 µM -0.854166285505055 0.173780458028653 no 2764 0.196506430372519 3871 629853 An antioxidant.
SGTC_2263 7948595 193.29 µM -0.854276214387985 0.173749944277273 no 2765 0.196475981525381 3885 2971371
SGTC_1033 k072-0102 21.3 µM -0.854439855764406 0.173704527475799 no 2766 0.196430660323996 3879 5965931
SGTC_413 propylparaben 100 µM -0.856116622397918 0.173239595217583 no 2767 0.195966637566552 3865 7175 A pharmaceutical preservative.
SGTC_1026 k007-1105 30.6 µM -0.856879929638024 0.173028208829995 no 2768 0.195755622943224 3902 7066794
SGTC_1042 0350-0096 82 µM -0.861389331433693 0.171782753073941 no 2769 0.194511824953579 3914 3122515
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.862187184931531 0.171562990805821 no 2770 0.194292260252914 3945 688664
SGTC_2462 5162487 171.77 µM -0.864288108520886 0.170985168219497 no 2771 0.193714820487843 3816 2259986
SGTC_3052 9092717 49.47 µM -0.864513505877592 0.170923250619036 no 2772 0.193652932137364 3927 25237534
SGTC_1560 lithocholic acid 53.1 µM -0.865802147386017 0.170569530890117 no 2773 0.193299335696558 3788 9903 A bile acid which acts as a detergent.
SGTC_703 3875-0075 71.8 µM -0.865874056421569 0.170549806365903 no 2774 0.193279615849715 3950 2850814
SGTC_2305 7443522 69.23 µM -0.867525698911309 0.170097165727249 no 2775 0.192827018616708 3844 5415886
SGTC_455 paf C-16 10 µM -0.868363480481685 0.169867862200559 no 2776 0.192597690233354 3901 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2566 crystal violet carbinol 226 nM -0.868880189149322 0.169726536229886 no 2777 0.192456333215986 3978 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1482 3346-2049 8.48 µM -0.869498252234426 0.169557587699378 no 2778 0.192287331808379 3931 3826804
SGTC_832 4083-0019 164 µM -0.872363076214367 0.16877589322612 no 2779 0.191505168570799 3996 1990758
SGTC_1259 0671-0132 43 µM -0.875440100304053 0.167938881620985 no 2780 0.190667244419476 3862 X1259
SGTC_742 0kpi-0133 140 µM -0.877390559298284 0.167409704110965 no 2781 0.190137269586536 3999 2728852
SGTC_1619 st003326 88.7 µM -0.877817923607239 0.167293899891351 no 2782 0.1900212680201 3921 2849032
SGTC_201 4262-0159 12.803 µM -0.877978300788089 0.16725045532031 no 2783 0.189977747291674 3971 1341029
SGTC_463 ikarugamyin 104 µM -0.879723269777076 0.166778230785253 no 2784 0.189504620150564 3992 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2087 5276107 200 µM -0.87998378578923 0.166707803661419 no 2785 0.189434046653573 3905 144405
SGTC_2432 5630864 12.22 µM -0.880893034472375 0.166462150475013 no 2786 0.189187858967239 3994 5714970
SGTC_138 0850-0259 40.9225 µM -0.881285700170843 0.16635613563928 no 2787 0.189081601951235 3920 6813004
SGTC_1712 st032288 53.4 µM -0.881565667793471 0.166280574507366 no 2788 0.18900586396677 3879 2883011
SGTC_36 0335-0881 14.2 µM -0.881680799851117 0.166249507673558 no 2789 0.188974723395846 3864 23828853
SGTC_750 4073-0104 132 µM -0.8819594452104 0.166174334496505 no 2790 0.188899369324097 3747 22330957
SGTC_1896 st058441 89 µM -0.883302485186436 0.165812316074139 no 2791 0.188536430713872 3967 688759
SGTC_981 1488-1094 54.9 µM -0.884723478461288 0.165429840729572 no 2792 0.188152894760217 3913 3449522
SGTC_1575 cyproterone acetate 48 µM -0.885236943886349 0.165291776581203 no 2793 0.188014425386537 3979 9880 An androgen receptor antagonist and liver toxin.
SGTC_629 3448-6466 76.7 µM -0.885538459359477 0.165210737765807 no 2794 0.187933143181674 3949 573744
SGTC_3264 9137442 49.47 µM -0.885845118254131 0.16512834292572 no 2795 0.187850496677129 3911 17015726
SGTC_987 1497-1013 404 µM -0.887268336297911 0.164746292950362 no 2796 0.187467224321417 3895 1676435
SGTC_2687 chenodiol 100 µM -0.88791845917548 0.164571964044521 no 2797 0.187292307276823 4032 5702181 A cholesterol synthesis inhibitor.
SGTC_393 acivicin 6.25 µM -0.888707171355981 0.164360633292458 no 2798 0.187080237979272 3810 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2302 7771753 200 µM -0.88948392503763 0.164152678783225 no 2799 0.18687152932042 3975 2203047
SGTC_2904 7225135 42.03 µM -0.890992469455406 0.163749295125778 no 2800 0.186466605105329 4046 4446116
SGTC_2656 pseudo-anisatin 100 µM -0.892004324388195 0.163479086711945 no 2801 0.186195307266213 3984 6708809 A neurotoxin.
SGTC_537 1334-0398 209 µM -0.892315450780045 0.163396060941125 no 2802 0.186111937471693 3951 5846986
SGTC_2872 9044037 25.97 µM -0.894139151271088 0.162909947457061 no 2803 0.185623721981909 3958 6465195
SGTC_2026 5148700 152 µM -0.895794899365034 0.162469417507598 no 2804 0.185181157284741 3938 79838
SGTC_2295 7971645 200 µM -0.895817856657362 0.162463314921933 no 2805 0.185175025642798 4021 2978226 YKL099C UTP11
SGTC_1134 3477-0009 42.5 µM -0.89704549498969 0.162137197193762 no 2806 0.184847320539903 4071 3973534
SGTC_3102 9121669 49.47 µM -0.897715609935297 0.16195936353671 no 2807 0.184668592594168 3980 41905072
SGTC_1888 azatryptophan 97.5 µM -0.900201207749907 0.161300851104039 no 2808 0.184006591779967 4006 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_72 0744-0168 198.391 µM -0.900496336597385 0.161222778416236 no 2809 0.183928086997787 3870 677577
SGTC_872 0588-0139 234 µM -0.901190892621286 0.161039139500321 no 2810 0.183743416216176 3934 2047100
SGTC_139 0099-0334 718.624 µM -0.902710045499486 0.160637955191475 no 2811 0.183339901779357 4009 97690
SGTC_1198 1612-1005 86.7 µM -0.906619081177891 0.159608644026203 no 2812 0.182304133884402 4065 6998509
SGTC_3032 9089427 49.47 µM -0.906880360725142 0.159539999209051 no 2813 0.182235033877236 4003 17173707
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.909752308295362 0.158786738923257 no 2814 0.181476575593122 3977 688751
SGTC_1703 st026983 48.3 µM -0.910036670106205 0.158712282975653 no 2815 0.181401585584622 3988 1104023
SGTC_1005 4092-0690 4.4 µM -0.911518578595542 0.15832463759983 no 2816 0.1810111005806 4017 1529343
SGTC_1344 1488-0097 29.1 µM -0.911574876933215 0.158309923044553 no 2817 0.180996276280147 4010 747966
SGTC_2776 terbinafine 19.92 µM -0.911993855772996 0.158200443784261 no 2818 0.180885975994374 4000 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2010 4012422 159 µM -0.912528593814894 0.158060788810921 no 2819 0.180745262174814 3986 952393
SGTC_696 1560-0013 611 µM -0.91372784771247 0.157747879775127 no 2820 0.180429933731297 4041 1650269
SGTC_895 0964-0006 13.7 µM -0.916327625542666 0.157070944436056 no 2821 0.179747541363335 3974 6738897
SGTC_870 0573-2213 57.6 µM -0.917340898325862 0.156807624661606 no 2822 0.179482016182681 3976 3916321
SGTC_2363 9053361 176 µM -0.917550139637813 0.156753285210733 no 2823 0.179427215836292 4067 6469797 YMR079W SEC14
SGTC_2496 diffractaic acid 79.83 µM -0.920372324836881 0.156021581642136 no 2824 0.178689112896893 3992 94870 An apoptosis inducer which activates caspases.
SGTC_181 1447-1644 8.07 µM -0.920997485659819 0.155859802207698 no 2825 0.178525869870438 4010 534600
SGTC_2028 5153890 36.43 µM -0.922011074616447 0.155597740237143 no 2826 0.178261399526199 3962 2830968 YPR165W RHO1
SGTC_1910 st062352 60.4 µM -0.922585387748539 0.155449381472022 no 2827 0.178111656715825 3927 2245730
SGTC_50 0929-0078 56.389 µM -0.923851547233974 0.155122632119938 no 2828 0.177781806434617 3873 1377751
SGTC_528 3492-0019 172 µM -0.924633455370545 0.154921076929346 no 2829 0.177578302238644 3989 2869262
SGTC_390 dec-rvkr-cmk 16.7 µM -0.925570511919219 0.154679756547674 no 2830 0.17733461191529 4029 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2600 tangeritin 87.95 µM -0.928309758705582 0.153975742793278 no 2831 0.176623456721286 3939 68077 A bioactive flavone.
SGTC_193 1273-0060 1.558 µM -0.931773074518404 0.153088675690472 no 2832 0.175726906224935 3823 2847393 YHR072W ERG7
SGTC_483 fpl-64176 144 µM -0.933234902447897 0.152715272955808 no 2833 0.175349348848003 4052 3423
SGTC_2249 haloperidol 116.36 µM -0.934172351975499 0.152476133269122 no 2834 0.175107497529852 3989 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.934339957069488 0.152433404069752 no 2835 0.175064279629612 4062 688788
SGTC_2715 st079500 56.4 µM -0.935821590278115 0.152056022540016 no 2836 0.17468252666637 3962 28246688
SGTC_2945 9067681 61.76 µM -0.936024178988492 0.152004470153261 no 2837 0.174630369399872 4092 16456930
SGTC_959 1222-0044 107 µM -0.938444221170509 0.151389544048388 no 2838 0.174008084694428 4004 6083612
SGTC_931 2812-0076 566 µM -0.939550588005434 0.151108971043365 no 2839 0.173724065960055 3990 3450959
SGTC_3098 9119039 49.47 µM -0.93967176413524 0.15107826199045 no 2840 0.173692976402556 4015 17161528
SGTC_1973 st070275 50.2 µM -0.939759026445071 0.151056150117325 no 2841 0.173670590137745 3956 17118334
SGTC_1369 1866-0067 208 µM -0.94150071516129 0.150615264551093 no 2842 0.173224161472428 4020 3531355
SGTC_3253 9135987 49.47 µM -0.942409778141606 0.150385487953605 no 2843 0.172991441476517 4017 4182430
SGTC_3315 9136395 68.55 µM -0.944402748903418 0.149882558339279 no 2844 0.172481938645437 4017 16876844
SGTC_513 4245-1575 41.7 µM -0.945126792367211 0.149700122826598 no 2845 0.17229707423275 3936 719745
SGTC_2012 4023501 200 µM -0.950838582667621 0.148266132136647 no 2846 0.170843161652926 4052 3477460
SGTC_214 4373-3496 70 µM -0.952607351220614 0.147823938260916 no 2847 0.170394525592926 4101 3779166
SGTC_3170 9103054 49.47 µM -0.953156675478816 0.14768678654539 no 2848 0.170255346951047 4038 16432970
SGTC_129 0088-0017 176.636 µM -0.954038390172809 0.147466823972295 no 2849 0.170032105067314 3873 182446
SGTC_1809 st050081 57.6 µM -0.954127331218781 0.147444647921626 no 2850 0.17000959645153 4122 5036894
SGTC_2777 climbazole 1.536 µM -0.954368939886403 0.147384417881136 no 2851 0.169948461358469 3923 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2385 9074692 200 µM -0.956056395322944 0.146964215932715 no 2852 0.169521871577715 4056 17046906
SGTC_1078 idebenone 36.1 µM -0.95614982636855 0.14694097368582 no 2853 0.16949827224182 4089 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.95620725180338 0.146926689549007 no 2854 0.169483768450463 4036 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_520 3584-0023 682 µM -0.956238351353694 0.146918954162976 no 2855 0.169475914051099 4044 1340790
SGTC_224 benfluorex 43.875 µM -0.956636135285937 0.146820037521654 no 2856 0.169375471660016 4046 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.958924393860933 0.146251885762273 no 2857 0.168798417405437 4062 5024745
SGTC_1757 st041620 31.8375 µM -0.959036065693859 0.146224196598213 no 2858 0.168770288310905 4113 5289815
SGTC_583 1488-1091 88.9 µM -0.959056897341971 0.1462190317559 no 2859 0.168765041346168 4153 4303273
SGTC_682 0kpi-0099 17 µM -0.959258160473301 0.146169138397407 no 2860 0.168714353657855 4074 1714895 YML126C ERG13
SGTC_1470 k295-0292 231 µM -0.959508941670096 0.146106985457312 no 2861 0.168651208643237 4113 5045612
SGTC_1501 4491-0275 38.4 µM -0.959764135969333 0.146043757012676 no 2862 0.168586968035111 3966 5104718
SGTC_3184 9108758 49.47 µM -0.961563213535144 0.145598528599605 no 2863 0.168134528804336 4052 902885
SGTC_1854 st056233 32.9 µM -0.962574712144183 0.145348608252074 no 2864 0.167880496510391 3931 5393174
SGTC_1174 0739-0097 51.1 µM -0.965463472417731 0.144636445204722 no 2865 0.167156361571238 4080 728447
SGTC_1786 berberine 21.6 µM -0.966334078176602 0.144422277397537 no 2866 0.166938519471647 3965 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2756 carbadox 75.1 µM -0.969046454761712 0.143756407149712 no 2867 0.166261005808448 4031 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_476 mead acid 10 µM -0.969332359623728 0.143686340302192 no 2868 0.166189694385926 4070 5312531 An omega 9 fatty acid.
SGTC_1431 4049-0260 9.09 µM -0.97005848216872 0.14350849269211 no 2869 0.166008671103322 4039 3854841
SGTC_2143 5623677 140.463 µM -0.973083952781562 0.142769070734905 no 2870 0.165255789439144 3989 5375313
SGTC_609 0986-0026 86.3 µM -0.97854493675537 0.141440941695603 no 2871 0.163902438788902 4024 2848610
SGTC_1281 0884-0031 11.8 µM -0.978747154768804 0.141391922908116 no 2872 0.163852463242436 4075 1548255
SGTC_278 4092-0821 23.9 µM -0.979017879594062 0.141326315710259 no 2873 0.16378557261391 4066 877900
SGTC_1820 st053765 18.6 µM -0.980443150831271 0.140981257138378 no 2874 0.163433709246784 4136 3690829
SGTC_497 capsazepine 133 µM -0.981019939291682 0.140841779041007 no 2875 0.163291454439923 4032 2733484 A calcium channel blocker.
SGTC_62 0180-0423 3.232 µM -0.984617998702388 0.139973815734335 no 2876 0.162405872655965 4020 30102 YGL099W LSG1
SGTC_2044 5102272 200 µM -0.986132700920469 0.139609512151362 no 2877 0.162033999314295 4079 592666
SGTC_1571 st070080 73.4 µM -0.986427319760941 0.139538727846481 no 2878 0.161961732155411 4114 4315245
SGTC_120 rhodamine 6G 52.259 µM -0.987072225074379 0.139383869887562 no 2879 0.161803616396706 4092 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1450 4112-4260 37.6 µM -0.991209713206648 0.138393136721507 no 2880 0.160791594310099 4063 1633175
SGTC_1978 st071761 42 µM -0.991598049390666 0.138300395526063 no 2881 0.160696820599459 4102 5147680
SGTC_288 1315-0019 35.1 µM -0.992790917027686 0.138015783703619 no 2882 0.160405928622262 4149 6811474
SGTC_640 3381-0960 37.1 µM -0.994920627180616 0.137508640152108 no 2883 0.159887434864993 4138 1745025
SGTC_2317 5986382 200 µM -0.995502499183697 0.137370301708133 no 2884 0.159745964687305 4110 877883
SGTC_197 4544-0043 41.561 µM -0.995641770786295 0.137337204374026 no 2885 0.159712115820192 4064 896523
SGTC_2869 9037858 32.47 µM -0.996346334899186 0.137169851019189 no 2886 0.159540948985561 4037 27187042
SGTC_1184 1269-1718 139 µM -0.996609625520348 0.137107348025831 no 2887 0.159477015981101 4153 5403821
SGTC_254 nsc-64875 3.808 µM -0.996795807505671 0.137063161724268 no 2888 0.159431816847193 4089 56993
SGTC_1008 4106-0037 6 µM -0.99766895588913 0.136856068496789 no 2889 0.159219955769481 4030 2905394
SGTC_1080 nisoldipine 24.4 µM -0.998365233997864 0.136691078690159 no 2890 0.159051142773796 4076 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2112 5488546 200 µM -0.998680088066071 0.136616515655997 no 2891 0.158974844755118 4051 600757
SGTC_1792 st045773 43.6 µM -0.998716047683157 0.136608001550128 no 2892 0.158966132252186 4033 2919270
SGTC_2162 5663267 200 µM -0.998945894117816 0.13655358971809 no 2893 0.158910451127044 4074 6456493
SGTC_529 4076-0302 30.3 µM -1.00431231942611 0.13528740112236 no 2894 0.15761404872435 4046 5816522
SGTC_2978 9011784 42.97 µM -1.00745619837241 0.134549364430298 no 2895 0.156857798315306 4086 2994934
SGTC_2734 clemastine 41.6 µM -1.00927964836806 0.134122571739021 no 2896 0.156420268819561 4134 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2923 7992654 58.14 µM -1.00999983195254 0.133954263626909 no 2897 0.156247685277212 4107 2985126
SGTC_127 0180-0333 59.125 µM -1.01066888676406 0.133798034495068 no 2898 0.156087466587029 3966 771601
SGTC_3067 9117431 49.47 µM -1.0110771154557 0.133702771694652 no 2899 0.155989761180963 4139 17150885
SGTC_2122 5258151 111.688 µM -1.01322401514726 0.133202546333356 no 2900 0.155476586054222 4098 2173356
SGTC_1911 st060208 74.3 µM -1.0147229917903 0.132854050792802 no 2901 0.155118945568196 4154 688783
SGTC_744 1594-0068 283 µM -1.015064708677 0.132774693339374 no 2902 0.155037491500005 4077 668392
SGTC_722 3534-0461 190 µM -1.02086168185056 0.131433426200197 no 2903 0.15365998786787 4166 658262
SGTC_1573 oleylamine 1.06 µM -1.0216502368993 0.131251700627862 no 2904 0.153473235814525 4102 5356789 An amine of the fatty acid oleic acid.
SGTC_2802 7925815 54.55 µM -1.02176004836412 0.131226407920866 no 2905 0.153447241295563 4078 1262923
SGTC_217 ketoconazole 989 nM -1.0218041890021 0.131216242023693 no 2906 0.153436793166012 3959 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2624 nerol 100 µM -1.02381157282565 0.130754502252186 no 2907 0.152962141563343 4022 637566 A natural product oil.
SGTC_1646 st011709 75.6 µM -1.02515545616123 0.130446009673814 no 2908 0.152644921116459 4054 5757843
SGTC_1011 4112-3381 17.4 µM -1.02790413253046 0.129816611199291 no 2909 0.151997462726507 4196 2877139
SGTC_1111 tnp00062 510.699 nM -1.03104470691617 0.129100052597546 no 2910 0.151259927620457 4169 676306
SGTC_1296 1068-0102 11.9 µM -1.03143383485776 0.129011459840027 no 2911 0.151168710515074 4121 767053
SGTC_256 clotrimazole 625 nM -1.03433093167991 0.128353203141397 no 2912 0.150490740609381 4059 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_77 0828-0286 12.516 µM -1.03502077627319 0.128196806142509 no 2913 0.150329604283404 4045 745345
SGTC_1447 4239-0816 81.9 µM -1.04093681063731 0.126860995627608 no 2914 0.148952438034225 4143 1341554
SGTC_1459 k035-0031 35.7 µM -1.04105659818465 0.126834048670169 no 2915 0.148924640588601 3908 3877128 YMR208W ERG12
SGTC_2857 9024691 58.44 µM -1.04108140443756 0.126828468846641 no 2916 0.148918884576515 4230 16478292
SGTC_2029 5175081 200 µM -1.04385864897092 0.126204846472145 no 2917 0.148275396076114 4097 1380876
SGTC_1164 k060-0068 93.7 µM -1.04581736580811 0.125766309419745 no 2918 0.14782268092893 4138 5963676
SGTC_688 0527-0193 473 µM -1.04792389628542 0.125295865911727 no 2919 0.147336835767625 4203 4007154
SGTC_826 1683-5028 118 µM -1.05278379385612 0.124215214048168 no 2920 0.14622004707277 4199 722377
SGTC_2647 atorvastatin 60.16 µM -1.05312383636181 0.124139846644398 no 2921 0.146142119781756 4116 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2355 9061122 103.12 µM -1.05383210138654 0.123982968717707 no 2922 0.145979896785952 4163 5302957
SGTC_1126 isoteolin 1.0172 µM -1.05516229239896 0.123688711702177 no 2923 0.145675553244116 4092 133323
SGTC_2245 6637752 200 µM -1.05791744038747 0.123080790290818 no 2924 0.145046541646058 4211 681890
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.05826706649143 0.123003795553155 no 2925 0.144966851481842 4130 442882
SGTC_2718 lomofungin 53.02 µM -1.05843948868077 0.122965837135344 no 2926 0.144927562202348 4138 5351222 A RNA synthesis inhibitor.
SGTC_2732 terfenadine 20 µM -1.05900263664776 0.122841918396399 no 2927 0.1447992894677 4202 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1205 4161-2785 76 µM -1.05904655896278 0.122832257127446 no 2928 0.144789288144311 4220 3498106
SGTC_2153 5569715 200 µM -1.05985137383383 0.122655322242564 no 2929 0.144606110266431 4181 2054701
SGTC_2388 9080168 200 µM -1.06178182189415 0.122231650988445 no 2930 0.144167372027018 4138 15943073
SGTC_2325 6158266 200 µM -1.06344693182789 0.121867039047429 no 2931 0.143789659554574 4178 3623240
SGTC_2407 paclitaxel 400 µM -1.06363808222934 0.121825231461306 no 2932 0.143746341881964 4267 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3135 9127742 49.47 µM -1.06574387267465 0.12136532897015 no 2933 0.143269719637488 4254 3643468
SGTC_1483 3453-0561 55.9 µM -1.06606865744164 0.121294505111147 no 2934 0.1431963033294 4165 4546991
SGTC_153 4077-0274 519.67 µM -1.06706250482042 0.121077963353333 no 2935 0.142971805945207 4162 3121976
SGTC_1012 4112-3522 18 µM -1.06755400515792 0.120970974689038 no 2936 0.142860870257998 4201 3112398
SGTC_1489 4065-0444 182 µM -1.06908121358743 0.120638959994427 no 2937 0.142516538014544 4144 2877968
SGTC_2319 6033012 152.6 µM -1.06934101706363 0.120582542703425 no 2938 0.142458017302298 4119 847246
SGTC_3005 9076496 71.4286 µM -1.06966994964124 0.120511140423792 no 2939 0.142383948584848 4129 21368410
SGTC_2984 9022109 38.96 µM -1.07841224737231 0.118624329065754 no 2940 0.140424911893189 4191 6459207
SGTC_534 k292-0788 63.4 µM -1.0814692564162 0.117969500260982 no 2941 0.139744214535939 4235 4146317
SGTC_2659 sanguinarine 24.21 µM -1.08367150367943 0.117499353666358 no 2942 0.139255237371967 4131 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_190 3970-0790 3.722 µM -1.0850462614853 0.117206536996933 no 2943 0.138950583209131 4103 2832352
SGTC_2439 5492030 7.2 µM -1.08706222936044 0.116778081132688 no 2944 0.138504654417476 4176 5722370
SGTC_1617 st002906 78 µM -1.08756546098794 0.116671302159438 no 2945 0.138393492669913 4167 5150859
SGTC_301 4119-0100 24.5 µM -1.0901646256493 0.11612089662257 no 2946 0.137820316359717 4208 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1644 st010134 20.9 µM -1.09184275091795 0.115766513180972 no 2947 0.137451112298362 4163 3818134
SGTC_2867 9039098 71.43 µM -1.09242991586039 0.115642698338441 no 2948 0.137322089856546 4140 6463460
SGTC_871 0574-0004 149 µM -1.09315951081471 0.115488980533421 no 2949 0.137161885400238 4150 9551173
SGTC_2078 5212016 200 µM -1.09325464042551 0.115468948452647 no 2950 0.137141006253487 4038 1899708
SGTC_779 1360-0071 233 µM -1.0954087554278 0.115016002803564 no 2951 0.136668800023146 4246 7566
SGTC_2970 9090938 41.86 µM -1.09613179751594 0.114864252394879 no 2952 0.136510550562081 4265 17217104
SGTC_656 4090-1979 187 µM -1.09794776523634 0.114483749476773 no 2953 0.136113649459532 4248 22330961
SGTC_757 1066-0008 322 µM -1.1001682257148 0.114019712853259 no 2954 0.135629415998999 4231 6842497
SGTC_76 0433-0009 400.328 µM -1.10085585992571 0.113876281680715 no 2955 0.135479697760285 4258 2841569
SGTC_3147 9097027 49.47 µM -1.10246840117411 0.113540431849861 no 2956 0.135129044317318 4188 25236841
SGTC_3347 9188721 44.724 µM -1.10332277046975 0.11336277574791 no 2957 0.134943510778571 4216 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_401 neomycin 50 µM -1.10377933732893 0.113267919336888 no 2958 0.134844435083552 4165 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1387 3342-1166 1.8 µM -1.10567684141324 0.112874300234336 no 2959 0.134433208613041 4164 3418228
SGTC_1010 4112-3296 15.2 µM -1.10753952908067 0.112488854186612 no 2960 0.13403036583067 4271 704384
SGTC_261 5-fluorouridine 15.376 µM -1.11065044571506 0.111847210251956 no 2961 0.133359419993908 4240 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2507 purpurin 79.67 µM -1.11328773570614 0.111305308022757 no 2962 0.132792436009941 4212 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_581 0958-0271 211 µM -1.11771257924072 0.110400331656351 no 2963 0.13184488425048 4206 4591145
SGTC_2805 7950783 58.44 µM -1.11793416483125 0.110355151721288 no 2964 0.131797556072368 4235 1178958 YDL195W SEC31
SGTC_1624 st003710 6.25 µM -1.11966763067854 0.110002166229078 no 2965 0.131427711871864 4247 24207033
SGTC_2980 9014342 25.29 µM -1.12284671467983 0.109356916318315 no 2966 0.130751300698445 4279 2996599
SGTC_2478 5763493 32.33 µM -1.12348531337935 0.109227630293563 no 2967 0.130615717323068 4138 1365576 YLR208W SEC13
SGTC_2021 4019055 173 µM -1.12697158160693 0.108523761985872 no 2968 0.129877248237931 4065 44827708 YER133W GLC7
SGTC_1224 0823-0416 294 µM -1.12877314903906 0.108161311710855 no 2969 0.129496771200165 4285 3598164
SGTC_174 3553-0389 74.3 µM -1.13119163120104 0.107676118003964 no 2970 0.128987221777697 4303 738071
SGTC_123 0083-0120 66.675 µM -1.132105867509 0.107493113774694 no 2971 0.128794964183117 4209 16001701
SGTC_1135 dihydrocapsaicin 536.708 nM -1.13300156613565 0.107314037754895 no 2972 0.128606797813228 4129 107982 A Capsaicinoid.
SGTC_3023 9089636 49.47 µM -1.13328367674035 0.107257680261031 no 2973 0.128547572172012 4299 17249241
SGTC_1754 st042065 16.137 µM -1.13420635430435 0.107073505154845 no 2974 0.128353999610804 4005 1126236 YIL048W NEO1
SGTC_772 k072-0172 35.3 µM -1.13465213985434 0.106984603939555 no 2975 0.128260548855378 4269 5861980
SGTC_796 1234-0020 70.7 µM -1.13628436724121 0.106659549813204 no 2976 0.127918785594569 4167 46495034
SGTC_2469 5655019 90.81 µM -1.14108143602367 0.105708352587091 no 2977 0.126918017863009 4283 2788239
SGTC_1881 5652484 16 µM -1.14153456398207 0.105618821142647 no 2978 0.126823768501825 4219 2255129
SGTC_2250 alverine citrate 130 µM -1.1449237184306 0.104950912208332 no 2979 0.126120378909908 4118 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_544 k015-0020 52.4 µM -1.14494482869557 0.104946761561022 no 2980 0.12611600619693 4235 3008304
SGTC_2254 7938975 95.19 µM -1.14683492112988 0.10457561782014 no 2981 0.125724926751504 4321 2969277
SGTC_1108 betulinic acid 729.144 nM -1.14828666080366 0.104291196522944 no 2982 0.125425121979923 4228 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1964 st076914 61 µM -1.14850184521272 0.104249085873933 no 2983 0.125380725856102 4278 24208661
SGTC_560 2332-1943 155 µM -1.14989954346739 0.103975862410757 no 2984 0.125092624475625 4209 21177716
SGTC_2436 5633522 8.09 µM -1.15250451857857 0.103468025763648 no 2985 0.124556907012778 4238 5724242
SGTC_592 k241-0073 46.5 µM -1.15375981814585 0.103223950479391 no 2986 0.124299326044216 4267 4230158
SGTC_3227 9130768 49.47 µM -1.15466799632666 0.103047628879815 no 2987 0.124113205006943 4301 17720899
SGTC_1228 0124-0032 52.5 µM -1.15467493754697 0.103046282093941 no 2988 0.124111783232122 4314 X1228
SGTC_1750 st081859 2.357 µM -1.15769150217104 0.102462195860172 no 2989 0.123494976524715 4197 5291695
SGTC_1821 st053465 65.6 µM -1.15978171116707 0.102058890717596 no 2990 0.123068846038337 4256 675086
SGTC_1627 st003713 25.6 µM -1.15992307345864 0.102031656668655 no 2991 0.123040063792881 4262 16195070 YER133W GLC7
SGTC_255 tunicamycin 200.472 nM -1.16185471249232 0.101660047846725 no 2992 0.122647242740123 4172 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1437 4092-1038 11.6 µM -1.16476329000656 0.101102356168328 no 2993 0.122057411130314 4297 3977136
SGTC_19 0279-0214 38.434 µM -1.17207134702641 0.0997109533905225 no 2994 0.120584206269253 4328 3566274 YBR002C RER2
SGTC_2206 7254556 146.969 µM -1.1721822344754 0.0996899494913623 no 2995 0.120561949714207 4280 4398905
SGTC_2251 lansoprazole 556 µM -1.17231636136527 0.0996645479815126 no 2996 0.120535032566358 4190 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1801 st050089 28.441 µM -1.17302347464314 0.0995307101034553 no 2997 0.120393196066797 4307 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1886 st057356 49.9 µM -1.17335537028931 0.0994679363329924 no 2998 0.120326663246861 4238 24207747
SGTC_8 0354-0001 70 µM -1.17511347995239 0.0991358952202711 no 2999 0.119974659180124 4247 4993152
SGTC_1227 3909-8010 46.6 µM -1.17568490712254 0.0990281487634161 no 3000 0.119860405998337 4241 15982272
SGTC_2004 4023728 41.89 µM -1.17713560916651 0.0987549939124623 no 3001 0.119570692111394 4243 360084 YDR527W RBA50
SGTC_1765 st044815 90.4 µM -1.18143215006847 0.0979492273950749 no 3002 0.118715546235472 4289 645695
SGTC_2275 7947463 200 µM -1.18998508803435 0.0963595847436333 no 3003 0.117026126556038 4236 1225414
SGTC_409 arachidonic acid 100 µM -1.19180794635518 0.0960232544214681 no 3004 0.116668279627362 4268 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1855 st056195 39.6 µM -1.19201830570033 0.095984497250518 no 3005 0.116627033787608 4215 4028379
SGTC_721 1187-1332 279 µM -1.19394735406316 0.0956296205117671 no 3006 0.116249281143685 4236 25730
SGTC_2674 ligustilide 100 µM -1.19439407837314 0.0955475768736846 no 3007 0.116161926056958 4333 5319022 A signalling regulator.
SGTC_3014 9081533 49.47 µM -1.19512561439482 0.0954133377180266 no 3008 0.116018977847377 4332 21367265
SGTC_471 1-acyl-paf 4 µM -1.19593428004168 0.0952651066478632 no 3009 0.115861103240452 4225 16759367
SGTC_1807 st050092 58.9 µM -1.19609217648752 0.0952361835070618 no 3010 0.115830295158449 4300 5008496
SGTC_1546 5-methoxyflavanone 78.7 µM -1.1983897230924 0.0948160550352507 no 3011 0.115382665714883 4296 147795
SGTC_618 k072-0232 33.2 µM -1.20243418578553 0.0940798069294834 no 3012 0.114597675442767 4335 5872756 YGL099W LSG1
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.20287186124658 0.0940003867553222 no 3013 0.114512955417284 4284 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3020 9089140 49.47 µM -1.20445242769785 0.0937139905943765 no 3014 0.114207379328804 4303 17217859
SGTC_2768 sulfasalazine 50.2 µM -1.20523540102746 0.0935723558922239 no 3015 0.114056219811839 4285 5384001 An antioxidant and salicylic acid derivative.
SGTC_2951 9072950 58.06 µM -1.20657175278884 0.0933309839334749 no 3016 0.113798555300246 4244 16488155
SGTC_2241 6772625 37.8075 µM -1.20809684311008 0.0930560843764946 no 3017 0.113505006947214 4122 2285411
SGTC_2059 5238311 157 µM -1.20844207415284 0.092993939177282 no 3018 0.113438632124485 4243 703021
SGTC_373 0844-0104 25.9 µM -1.21018270718414 0.092681074257591 no 3019 0.113104396090089 4305 5375804
SGTC_423 5-fluorouracil 457 µM -1.21034467331271 0.0926520017745547 no 3020 0.113073331157988 4225 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_834 0312-0008 75.7 µM -1.21751277651143 0.0913720925347624 no 3021 0.111704589145556 4315 6385573 YIL048W NEO1
SGTC_2210 7115885 190.385 µM -1.22333700651189 0.0903418288805721 no 3022 0.110601217634149 4406 2927039
SGTC_2561 acetosyringone 100 µM -1.22756118247643 0.089600018096948 no 3023 0.109805870567658 4281 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_167 3672-0051 66.205 µM -1.23048632102628 0.0890889927828308 no 3024 0.10925752313699 4220 3237971
SGTC_337 1315-0038 354 µM -1.23105277267074 0.0889902841793704 no 3025 0.109151563699746 4283 1626437
SGTC_3185 9108267 49.47 µM -1.23599367221533 0.0881327437036712 no 3026 0.108230457890496 4323 4910486
SGTC_2342 7990637 118.86 µM -1.23778817156257 0.0878228209636901 no 3027 0.107897307734118 4337 2033102 YER133W GLC7
SGTC_2787 5284540 71.43 µM -1.23846967551262 0.0877053336344346 no 3028 0.107770979707648 4346 736958
SGTC_2437 5741531 144.16 µM -1.2384782085032 0.087703863339967 no 3029 0.107769398652388 4338 2262990
SGTC_1768 st044301 37.178 µM -1.24088382580016 0.0872900914613274 no 3030 0.107324334290117 4325 3931349
SGTC_234 nsc-17383 10.7 µM -1.2424603298484 0.0870197206278845 no 3031 0.107033384184148 4339 408974
SGTC_1690 st023502 41.2 µM -1.2539761326277 0.0850637023277374 no 3032 0.104925340358328 4335 24207482
SGTC_647 0140-0236 81 µM -1.25791236807815 0.0844027254641732 no 3033 0.104211725119667 4346 990837
SGTC_1018 4259-0013 28.1 µM -1.25846175053098 0.0843107798846696 no 3034 0.104112405913256 4378 6801262
SGTC_602 3130-1533 38.1 µM -1.26046749035563 0.083975733988 no 3035 0.103750384174612 4379 720941
SGTC_3158 9100007 49.47 µM -1.26195501665182 0.0837278987187883 no 3036 0.103482486680244 4356 19297233
SGTC_2030 5175110 200 µM -1.26335218051962 0.0834956194280761 no 3037 0.103231320670908 4343 2831986
SGTC_1153 4055-0057 267 µM -1.26765621501891 0.0827831149604692 no 3038 0.102460373684845 4388 882706
SGTC_2676 harmalol 100 µM -1.26988709557463 0.0824156123450231 no 3039 0.102062425228133 4306 5459187 A monoamine oxidase inhibitor
SGTC_162 k030-0015 37.8 µM -1.27181789460071 0.0820985362634298 no 3040 0.101718914710719 4411 1809920 YMR134W ERG29
SGTC_3066 9117245 49.47 µM -1.27354915368212 0.0818150108744063 no 3041 0.101411620975197 4377 17176980
SGTC_15 0266-0086 27.098 µM -1.27529960674107 0.0815290930708076 no 3042 0.101101608443875 4411 1712902 YIL048W NEO1
SGTC_221 trifluoperazine 10.304 µM -1.276409588075 0.0813481802576043 no 3043 0.100905384319031 4327 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_270 tamoxifen 5.46 µM -1.27694466041964 0.0812610785302134 no 3044 0.100810892695006 4381 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_706 4262-0057 46.9 µM -1.27771666704381 0.0811355314854228 no 3045 0.100674673161569 4345 883298
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.27922843909222 0.0808901046352927 no 3046 0.100408311963149 4470 16725076
SGTC_1360 1598-0022 39.8 µM -1.27971943634145 0.0808105149573347 no 3047 0.100321913212126 4386 761525
SGTC_168 3970-0862 530.542 µM -1.28238649128073 0.0803792232166711 no 3048 0.099853550307627 4306 3135186
SGTC_112 phenothiazine 287.218 µM -1.28449672681333 0.0800392094897411 no 3049 0.0994841040616643 4306 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_976 1348-1067 47.6 µM -1.2849462877694 0.0799669142594408 no 3050 0.0994055271234105 4380 5310671 YGL099W LSG1
SGTC_1242 0402-0103 60.1 µM -1.2851436794499 0.0799351867219897 no 3051 0.0993710401681674 4275 432868
SGTC_3115 9123671 49.47 µM -1.28595121359633 0.0798054877197949 no 3052 0.0992300442830063 4499 3286988
SGTC_3007 9078383 71.4286 µM -1.29705410850461 0.0780383420902272 no 3053 0.0973062850360479 4350 6496995
SGTC_2882 9058044 58.44 µM -1.30115386138155 0.0773933810517466 no 3054 0.0966028972585959 4385 18076804
SGTC_2549 cedrol 20.94 µM -1.30131990726847 0.0773673447670723 no 3055 0.0965744879479698 4310 6708665 A sedative which affects the nervous system.
SGTC_2520 obtusaquinone 4.71 µM -1.30259014588291 0.0771683892111021 no 3056 0.0963573618861084 4411 5967872
SGTC_1340 1486-1359 257 µM -1.30262488919616 0.0771629528854638 no 3057 0.0963514281418487 4305 4309068
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.30264810207236 0.077159320902555 no 3058 0.0963474638086049 4360 15053
SGTC_2011 4012611 177 µM -1.30324533006102 0.0770659207912856 no 3059 0.0962455094411034 4328 2049887
SGTC_3259 9138485 49.47 µM -1.30580822188333 0.0766660870162523 no 3060 0.0958088916806578 4380 17646153
SGTC_1051 3253-3903 78 µM -1.30756934173104 0.0763922525721479 no 3061 0.0955097106228089 4365 5509239
SGTC_1440 4100-1550 40 µM -1.30801977146774 0.0763223354344951 no 3062 0.0954333016397017 4369 742806
SGTC_554 4483-2211 187 µM -1.31046428533573 0.0759437391717129 no 3063 0.095019409314778 4433 747107
SGTC_2757 clomiphene 4.22 µM -1.31319841075949 0.0755219851273831 no 3064 0.0945580496880384 4397 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_447 ml7 120 µM -1.3161174267596 0.0750736831067804 no 3065 0.0940673163620944 4431 4216 Selective myosin light chain kinase inhibitor.
SGTC_2120 5538279 151.968 µM -1.3182806746056 0.0747427632241039 no 3066 0.0937048538897702 4344 2058197
SGTC_2315 7733312 200 µM -1.32085414302053 0.0743505414136858 no 3067 0.0932750012533441 4280 726316
SGTC_2785 7756463 72.73 µM -1.32220508370202 0.0741452748528914 no 3068 0.0930499343527574 4349 2201551
SGTC_2365 9042475 200 µM -1.32626810192136 0.0735305343600359 no 3069 0.0923754543090163 4425 6464479
SGTC_32 0928-0142 34.1 µM -1.32642301340443 0.0735071733941062 no 3070 0.0923498100667033 4370 2244242
SGTC_2266 7929956 200 µM -1.32872378808415 0.0731608796750505 no 3071 0.0919695569109497 4329 2967153
SGTC_2525 harmine 47.85 µM -1.32957965684349 0.0730323803544007 no 3072 0.0918284022203593 4366 5280953 A monoamine oxidase inhibitor
SGTC_1238 0333-0287 48.8 µM -1.33340850540605 0.0724596346478067 no 3073 0.0911988913664626 4368 7226
SGTC_2961 9083290 32.55 µM -1.33393008681044 0.0723818799254501 no 3074 0.0911133850766052 4326 17741490
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.33424880906397 0.072334397899002 no 3075 0.0910611641040406 4346 688761
SGTC_2193 5925765 200 µM -1.33749739457572 0.0718517965065818 no 3076 0.0905301660836636 4404 877370
SGTC_3022 9087993 49.47 µM -1.33900419889682 0.0716287896032388 no 3077 0.0902846529882355 4475 17173644
SGTC_545 4218-0007 221 µM -1.34246468122755 0.0711186490044822 no 3078 0.0897226873502525 4387 2840508
SGTC_176 1486-1328 72.834 µM -1.34810015370135 0.070293851169675 no 3079 0.0888130860096887 4443 22310231
SGTC_3059 1327-0034 3 µM -1.3503679858941 0.0699640185473897 no 3080 0.0884489872939034 4243 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.35094406574247 0.0698804236871752 no 3081 0.0883566755005905 4423 23847180
SGTC_2729 fluphenazine 10.66 µM -1.35281735458742 0.0696091223328753 no 3082 0.0880569935444117 4343 3372 An atypical antipsychotic.
SGTC_3353 9151644 39.2805 µM -1.35405642545338 0.069430118453362 no 3083 0.0878591883087207 4413 4909158
SGTC_2868 9035608 32.47 µM -1.3560564519976 0.0691419304276021 no 3084 0.087540603612565 4382 6462614
SGTC_620 0109-0052 432 µM -1.35626433628968 0.0691120289035749 no 3085 0.0875075391985801 4457 493037
SGTC_1378 2093-0007 380 nM -1.36242768746958 0.0682300287326864 no 3086 0.0865314754016168 4449 3618014
SGTC_2375 9072683 200 µM -1.36374488677051 0.0680426638507784 no 3087 0.0863239357454372 4456 16798029
SGTC_2653 dihydrofissinolide 100 µM -1.36500202198699 0.0678642134905857 no 3088 0.0861262072537396 4457 6857746
SGTC_3298 9116858 71.43 µM -1.36941610477226 0.0672404959725833 no 3089 0.0854346214666719 4479 2506942
SGTC_2703 st077852 53.4 µM -1.37111263946486 0.0670019551516035 no 3090 0.0851699227182788 4443 6281836
SGTC_1200 1643-0193 18.4 µM -1.37275238303792 0.0667720219763712 no 3091 0.0849146691826406 4435 5403974
SGTC_46 0329-0187a 2.197 µM -1.37513503074952 0.0664390037655221 no 3092 0.0845447928720288 4435 46494817
SGTC_2704 st078022 71.1 µM -1.37822443857407 0.0660091193965771 no 3093 0.0840670020691133 4443 54697681
SGTC_2186 6124449 200 µM -1.38107599211826 0.0656142475082268 no 3094 0.0836277982250812 4427 3834182 YLR033W RSC58
SGTC_2092 5303694 80.6725 µM -1.38155371578379 0.0655482737089756 no 3095 0.0835543868738723 4429 1963699
SGTC_2712 st079126 47.7 µM -1.38281621866133 0.0653741692314006 no 3096 0.0833606123324069 4408 3152970
SGTC_1097 itavastatin 7.23 µM -1.38950759574023 0.0644573824880988 no 3097 0.0823392263985508 4439 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1848 st056003 16.4 µM -1.3902003198897 0.064363045664319 no 3098 0.0822340281826936 4431 146492
SGTC_1868 st057644 42.7 µM -1.39280561088753 0.0640092111964356 no 3099 0.0818392906240376 4452 688665
SGTC_101 0490-5701 117.494 µM -1.39652704153381 0.0635064151118825 no 3100 0.0812779216555979 4300 4661669
SGTC_1204 4049-0315 18.3 µM -1.39991095425301 0.0630518935967755 no 3101 0.0807699926588573 4468 588402
SGTC_1003 4049-0218 100 µM -1.40046170634904 0.0629781578354397 no 3102 0.080687551452374 4429 295161
SGTC_3037 9091026 49.47 µM -1.4005181544232 0.0629706042541736 no 3103 0.0806791054214442 4310 25236398 YIL048W NEO1
SGTC_1128 3448-9350 235 µM -1.40296434079482 0.0626439460593703 no 3104 0.0803137363663766 4434 619386
SGTC_3154 9100113 49.47 µM -1.40298055594521 0.0626417851398838 no 3105 0.0803113186060268 4425 25237525
SGTC_3070 9117005 49.47 µM -1.40493701926901 0.0623814823127665 no 3106 0.0800200035994043 4537 8779016
SGTC_371 0195-0006 7.36 µM -1.4068062747506 0.062133570951104 no 3107 0.0797424207188084 4289 3928593
SGTC_1406 3909-7906 11.9 µM -1.41373453685845 0.0612214040779228 no 3108 0.0787199304012947 4471 X1406
SGTC_1262 0737-0114 49.6 µM -1.41510112614599 0.0610427223192658 no 3109 0.0785194240372395 4468 765919
SGTC_2336 9001819 198.65 µM -1.41568736983477 0.0609661959210108 no 3110 0.0784335289533405 4473 2989602
SGTC_2377 9073351 62.6 µM -1.41936632111608 0.06048766814049 no 3111 0.0778961229485765 4437 7337946 YHR072W ERG7
SGTC_1218 1348-1416 30.7 µM -1.42041398010376 0.060351936246801 no 3112 0.077743597583305 4411 6787668
SGTC_1920 st075728 45.7 µM -1.42101716389368 0.0602738975649667 no 3113 0.0776558848520727 4424 3400306
SGTC_3172 9105863 49.47 µM -1.42404508690847 0.0598833439029693 no 3114 0.0772167104320701 4548 2348785
SGTC_555 4296-0685 37 µM -1.42579283739 0.0596588159593966 no 3115 0.0769640745187439 4436 2908540 YHR072W ERG7
SGTC_6 0844-0013 19.835 µM -1.42602909535879 0.0596285153293825 no 3116 0.0769299718813801 4574 1584900
SGTC_2422 chlorphenesin carbamate 384.24 µM -1.42669993543521 0.0595425442754179 no 3117 0.0768332021364381 4414 2724 A muscle relaxant with antifungal properties.
SGTC_794 k038-0031 316 µM -1.42752007159769 0.0594375723003293 no 3118 0.0767150219583244 4438 6624242
SGTC_756 0508-1999 28.3 µM -1.42823036517915 0.0593467767211767 no 3119 0.0766127816456787 4459 6753853
SGTC_1937 st074714 47.2 µM -1.42928486909016 0.0592121819401379 no 3120 0.0764611865595075 4384 17250970
SGTC_1679 SEC14.276 6.7 µM -1.43220511685109 0.0588406965495716 no 3121 0.076042563890589 4431 1005053 YMR079W SEC14
SGTC_349 k015-0014 24 µM -1.43335388629048 0.0586950635422086 no 3122 0.0758783648144826 4468 2196908
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.435310547022 0.0584476632185875 no 3123 0.0755993118020625 4543 688664
SGTC_1503 4585-0012 61.3 µM -1.43903485484965 0.0579790249135027 no 3124 0.0750703238313767 4474 2922052
SGTC_191 3914-0123 66.505 µM -1.43992115260815 0.0578679362025049 no 3125 0.0749448539168486 4502 3144412
SGTC_1723 st034307 2.5525 µM -1.44067163119774 0.0577740019726483 no 3126 0.0748387365446707 4453 867466
SGTC_1678 st019265 80.2 µM -1.44743105320573 0.0569333471591054 no 3127 0.0738881168738385 4456 5367020
SGTC_18 0111-0177 500 nM -1.44796047517374 0.0568679129641334 no 3128 0.0738140524170499 4546 721752
SGTC_822 1487-0950 154 µM -1.45188920325464 0.0563841884284593 no 3129 0.0732662075459424 4470 1958375
SGTC_723 4182-0001 115 µM -1.45328224846683 0.0562134507160321 no 3130 0.0730727019675387 4474 744821 YLR208W SEC13
SGTC_3169 9102970 49.47 µM -1.45825736028814 0.0556070048609627 no 3131 0.0723848092544916 4543 17027839
SGTC_1316 1272-0050 65.9 µM -1.45863260455661 0.0555614743639593 no 3132 0.0723331273460673 4452 7340392
SGTC_1883 5-benzylidenerhodanine 20 µM -1.45978449580681 0.0554218927222836 no 3133 0.0721746554653743 4451 1273210
SGTC_2181 6316240 54.2555 µM -1.4600361807974 0.0553914314148307 no 3134 0.0721400652572421 4476 12779990
SGTC_3093 9117344 49.47 µM -1.46025417825645 0.0553650579779212 no 3135 0.0721101151500555 4496 24824913
SGTC_2036 5160441 105 µM -1.46595234240346 0.0546792019559109 no 3136 0.0713306353631955 4441 134534 YIL048W NEO1
SGTC_3228 9131799 49.47 µM -1.46698474737936 0.0545556590220631 no 3137 0.0711901022968285 4504 17015818
SGTC_158 k038-0087 26.446 µM -1.46720281192163 0.0545295925462178 no 3138 0.0711604461186394 4390 X158
SGTC_206 4546-0025 72.014 µM -1.47012855420261 0.0541808139730055 no 3139 0.0707634700755935 4514 6620745 YIL048W NEO1
SGTC_2145 5634607 200 µM -1.47253366814958 0.0538954237712485 no 3140 0.070438411080637 4472 308662
SGTC_481 bay k-8644 50 µM -1.47680597997333 0.0533914085476339 no 3141 0.0698638265722006 4449 2303 A calcium channel antagonist.
SGTC_2406 ethylparaben 405.7 µM -1.47781648342516 0.0532727448795194 no 3142 0.0697284525838633 4433 8434 A possible steroid mimic.
SGTC_1366 1683-0113 21.9 µM -1.47874020966137 0.05316445446341 no 3143 0.0696048806038265 4475 708623
SGTC_2592 piperlongumine 83.33 µM -1.47963877789448 0.0530592809016541 no 3144 0.0694848360000343 4465 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_425 3825-7017 13.1 µM -1.48143488790667 0.0528495484489749 no 3145 0.0692453618516186 4505 3397440
SGTC_2700 st077718 96.8 µM -1.48431026406407 0.052515159390881 no 3146 0.0688633142839539 4465 904970
SGTC_2836 9010338 19.48 µM -1.48895317726136 0.0519787638840786 no 3147 0.0682498494699095 4449 2994051
SGTC_1923 st058458 19.1 µM -1.49065849272153 0.0517828454130113 no 3148 0.0680255894246589 4481 3534982
SGTC_668 1682-0499 62.6 µM -1.49390655743964 0.0514113091415098 no 3149 0.0676000221403922 4475 682214
SGTC_1651 st011928 86.1 µM -1.50127394933093 0.0505764338978575 no 3150 0.0666423600088459 4509 720198
SGTC_808 0711-0032 135 µM -1.50214376509257 0.0504785829742432 no 3151 0.0665299921232345 4464 4252555
SGTC_1666 st014829 29 µM -1.50361043399874 0.0503139300132143 no 3152 0.0663408514862062 4499 3858230
SGTC_890 0929-0006 47.2 µM -1.51093416466396 0.0494981397068016 no 3153 0.0654026126420088 4497 1378169
SGTC_2907 7721985 69.9 µM -1.51521024255583 0.0490267306810486 no 3154 0.0648595850185849 4502 3267881
SGTC_908 3448-7491 47.7 µM -1.51640405467932 0.0488957632742235 no 3155 0.0647086072166402 4499 1203031
SGTC_2049 5262831 67.185 µM -1.51934522785802 0.0485742938907182 no 3156 0.0643378104756241 4451 763417
SGTC_2188 6126565 140.678 µM -1.52159162230586 0.0483299036307625 no 3157 0.0640557190087298 4410 874518
SGTC_1006 4099-6547 255 µM -1.52199617714363 0.0482859958995472 no 3158 0.0640050192863053 4512 3146833
SGTC_2261 9010538 184.68 µM -1.52277465038147 0.0482015953000357 no 3159 0.0639075470637872 4482 6457250
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.52578897077867 0.0478759011646128 no 3160 0.063531214163297 4581 688801
SGTC_3350 9150499 3.57 µM -1.52830998423406 0.047604863305239 no 3161 0.0632177960793787 4511 4910996 YPR165W RHO1
SGTC_1103 duloxetine 36.1 µM -1.53208976781822 0.0472007974184466 no 3162 0.0627501421902435 4567 60835 A selective serotonin reuptake inhibitor.
SGTC_3285 9112818 20.8695 µM -1.53588873964009 0.0467974550335787 no 3163 0.0622828351566669 4494 17017947 YPR165W RHO1
SGTC_450 aminopyrene 156 nM -1.53982126407321 0.0463828502916354 no 3164 0.0618019636045517 4478 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1247 0448-0043 5.84 µM -1.54006855282003 0.0463568775830917 no 3165 0.061771822103968 4498 3089013 YGL099W LSG1
SGTC_2123 5259487 200 µM -1.54009162454568 0.0463544549580378 no 3166 0.0617690105256712 4526 2173474
SGTC_977 1348-1378 135 µM -1.54180544536024 0.0461747808232507 no 3167 0.0615604392165892 4494 X977
SGTC_2760 etidronate 98.04 µM -1.54338804995846 0.0460093603035719 no 3168 0.0613683256871425 4473 3305 A chelator and antioxidant.
SGTC_650 1328-0195 38 µM -1.54449163617733 0.0458942908039977 no 3169 0.0612346379484426 4523 2780821
SGTC_2194 5927483 104.545 µM -1.54655961751393 0.0456792878186055 no 3170 0.060984736859998 4552 760979
SGTC_347 4534-1311 26.2 µM -1.54721934434446 0.0456108682306572 no 3171 0.0609051814456107 4541 2862016
SGTC_1147 3809-1045 12.3 µM -1.54915135697619 0.045410975035 no 3172 0.060672669803595 4536 325925
SGTC_1362 1611-0397 101 µM -1.55087139496677 0.0452336069417704 no 3173 0.0604662533672317 4500 27816
SGTC_3281 9140613 49.47 µM -1.55719894084593 0.0445859100280105 no 3174 0.0597116298901521 4508 16013766
SGTC_2855 9016525 58.44 µM -1.56326047341187 0.0439724691174775 no 3175 0.0589956706495011 4465 43811474
SGTC_448 monastrol 171 µM -1.56583505340015 0.043713983653188 no 3176 0.0586936187959562 4451 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_736 0958-0254 92.6 µM -1.57149542024292 0.0431499982305478 no 3177 0.0580338086826427 4586 6812352
SGTC_3097 9117246 49.47 µM -1.57354706868383 0.0429470338399367 no 3178 0.0577960992493028 4556 16423892
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.57390325367334 0.0429118760729965 no 3179 0.0577549088063415 4556 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1594 piperine 70.1 µM -1.58751227883074 0.041585905732113 no 3180 0.0561983341134483 4532 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_877 0771-0151 33.1 µM -1.5908041647669 0.0412702035953922 no 3181 0.0558268276950454 4540 6166523
SGTC_2314 7727897 200 µM -1.59671362160144 0.0407083442273342 no 3182 0.05516477893896 4515 900724
SGTC_906 1165-0455 526 µM -1.59870950496409 0.0405199878646004 no 3183 0.0549425823281069 4529 3252859
SGTC_1423 4048-0112 5.59 µM -1.60651921819521 0.0397897559652474 no 3184 0.0540799379062395 4597 X1423
SGTC_1977 st070720 65.3 µM -1.60902362650953 0.0395578644821598 no 3185 0.0538055877613891 4569 682188
SGTC_2133 5320837 200 µM -1.61117811395556 0.0393592539574188 no 3186 0.0535704533065453 4561 2841355
SGTC_2990 9074105 71.4286 µM -1.61614656582163 0.0389043313866677 no 3187 0.0530313142013626 4491 6502001
SGTC_469 w7 172 µM -1.6170317328305 0.0388237346694232 no 3188 0.0529357156546306 4650 45115570 A P450 inhibitor.
SGTC_1345 1488-0192 31.4 µM -1.61707968744193 0.0388193721658825 no 3189 0.0529305404346292 4588 658348
SGTC_304 1310-0298 97 µM -1.61922360018448 0.038624744762522 no 3190 0.0526995809674238 4295 1550234
SGTC_1045 1348-1485 165 µM -1.61988414313243 0.0385649402229537 no 3191 0.0526285833534877 4530 6810614
SGTC_509 pifithrin 175 µM -1.62171039612764 0.0383999867276862 no 3192 0.0524326858851905 4637 4817 A p53 inhibitor.
SGTC_3241 9133421 49.47 µM -1.62335676609581 0.0382517742832008 no 3193 0.0522565805759125 4634 17018221
SGTC_1547 harmine 94.2 µM -1.62347022751063 0.0382415772628074 no 3194 0.0522444614046769 4474 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2893 9048488 25.97 µM -1.62506937043254 0.0380980944982872 no 3195 0.0520738892260276 4580 6467338
SGTC_1597 7-benzyloxygramine 47.5 µM -1.63049069358306 0.0376149319102799 no 3196 0.0514989152624444 4458 260807
SGTC_2267 7931562 200 µM -1.63056756712884 0.0376081168780906 no 3197 0.0514907986680707 4519 934880
SGTC_484 loperamide 105 µM -1.6324463875925 0.0374418679117144 no 3198 0.0512927419095913 4661 3955 An opioid-receptor agonist.
SGTC_2903 5923464 63.88 µM -1.63740656931596 0.0370058446253473 no 3199 0.0507727732479396 4578 2876576
SGTC_2871 9038510 12.99 µM -1.640981663019 0.0366941580468286 no 3200 0.0504006108340855 4509 4945164
SGTC_966 1300-0360 30.2 µM -1.64413068497908 0.0364213993013013 no 3201 0.0500746054259027 4553 70588
SGTC_2992 9074591 71.4286 µM -1.65199588916093 0.0357473813343256 no 3202 0.0492676944340879 4509 17741321
SGTC_1965 Pectolinarigenin 58.4 µM -1.65296818260707 0.0356647739998368 no 3203 0.0491686695915164 4564 5320438 An anti-inflammatory.
SGTC_718 1130-0073 349 µM -1.65602441781328 0.0354061305491192 no 3204 0.0488584370184283 4578 6740020
SGTC_567 1080-0542 68.4 µM -1.66087530686008 0.0349987686637222 no 3205 0.0483692462730033 4477 5950415
SGTC_3106 9121286 49.47 µM -1.6696822439901 0.0342690246692164 no 3206 0.0474911243070611 4527 15943471
SGTC_370 0180-0345 38.7 µM -1.67806708202554 0.0335859229794859 no 3207 0.0466670020332321 4430 3989527
SGTC_929 2805-0021 398 µM -1.68208055927951 0.0332629386062497 no 3208 0.0462766098004319 4600 3098024
SGTC_2419 paclitaxel 166.5 µM -1.69392606926365 0.0323245601847021 no 3209 0.0451396662383912 4528 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3331 9141060 1.957 µM -1.69414175097818 0.0323076789196166 no 3210 0.045119175155651 4550 4906567 YPR165W RHO1
SGTC_98 0074-0023 107.663 µM -1.6992839506087 0.0319073520591781 no 3211 0.0446328475422817 4578 3563821
SGTC_2450 5739737 12.93 µM -1.7051441655 0.0314561309801201 no 3212 0.0440837701588204 4601 2262825
SGTC_2260 7964312 200 µM -1.70777227468346 0.0312554937367811 no 3213 0.0438393027229185 4600 231951
SGTC_500 h-89 112 µM -1.71080149293717 0.03102554894196 no 3214 0.0435588819490179 4577 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1426 4048-4480 71.7 µM -1.71142002263298 0.0309787695086266 no 3215 0.0435018017837414 4605 14224343
SGTC_719 2810-4230 27.3 µM -1.71816880779931 0.0304721411885774 no 3216 0.0428829146011829 4622 721079
SGTC_1155 4088-0394 48.2 µM -1.73017674655488 0.0295876862872303 no 3217 0.0417993507939407 4599 2326248
SGTC_149 3970-0822 46.1 µM -1.73482938902921 0.029250768288332 no 3218 0.041385514511157 4577 3114250 YBL034C STU1
SGTC_126 0417-1624 672.48 µM -1.7513120043428 0.028082731388913 no 3219 0.0399460905295398 4640 41912 YDL195W SEC31
SGTC_1800 st050079 29.0735 µM -1.75206236594335 0.0280304950026782 no 3220 0.0398815422965634 4434 3645560
SGTC_1099 5-nonyloxytryptamine 2.85 µM -1.75217063959824 0.0280229642218954 no 3221 0.0398722352927762 4624 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2189 6047310 154.431 µM -1.75452731257277 0.0278594670445762 no 3222 0.0396700970612903 4623 711535
SGTC_573 3702-0553 84.7 µM -1.76803402237719 0.0269376799974851 no 3223 0.0385276080392308 4577 1222756
SGTC_2526 patulin 37.61 µM -1.76842083344118 0.0269116610379035 no 3224 0.0384952881201904 4608 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1841 st054148 70 µM -1.77077121759587 0.0267540124280377 no 3225 0.0382993770222271 4631 675442
SGTC_3163 9099914 49.47 µM -1.77663781661827 0.0263638808942574 no 3226 0.0378139247146462 4696 16268368
SGTC_856 0433-0016 11.3 µM -1.77890904921059 0.0262141250767351 no 3227 0.037627337140172 4640 3911780
SGTC_1991 st073000 8.92 µM -1.78393766495074 0.0258850880327235 no 3228 0.037216897370965 4623 4301969 YIL048W NEO1
SGTC_1581 himbacine 57.9 µM -1.78989302067262 0.025499888341137 no 3229 0.0367355555320889 4636 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1909 st060837 51.5 µM -1.79547003173862 0.0251435244536495 no 3230 0.0362894216597954 4564 678937
SGTC_960 1222-0186 7.7 µM -1.79638215638654 0.0250856398748704 no 3231 0.0362168798608898 4611 3126296
SGTC_2962 9082311 13.18 µM -1.79663696380969 0.0250694894498735 no 3232 0.036196636108346 4605 16459453
SGTC_2782 7736369 71.43 µM -1.79769065849753 0.0250027957750212 no 3233 0.0361130212943718 4602 2950836 YOL077C BRX1
SGTC_3211 9128781 49.47 µM -1.79828063615586 0.0249655181048488 no 3234 0.0360662733644913 4530 17194361
SGTC_947 3447-0010 211 µM -1.80008829652476 0.0248515913016381 no 3235 0.0359233486422639 4579 748350
SGTC_986 1493-0483 84 µM -1.80184045274868 0.0247415790706944 no 3236 0.0357852555760313 4596 40079
SGTC_1737 st035557 69.7 µM -1.81146425716236 0.0241445908095253 no 3237 0.0350345085297657 4484 5716916
SGTC_1341 1486-1360 280 µM -1.82810737152816 0.0231407390876444 no 3238 0.033766719426613 4638 3976547
SGTC_970 1315-0089 19.5 µM -1.82999124802727 0.0230293569099932 no 3239 0.033625623777158 4614 6811083 YLR033W RSC58
SGTC_2931 9014674 55.67 µM -1.83411611017512 0.0227870547529545 no 3240 0.0333183802518138 4591 2996810
SGTC_3120 9124077 49.47 µM -1.83469934848698 0.0227529682109462 no 3241 0.0332751244438465 4717 18774327 YGL155W CDC43
SGTC_883 0850-0245 24.6 µM -1.8425301171588 0.0222994561757419 no 3242 0.0326988226705766 4665 6823229 YPR165W RHO1
SGTC_459 nigericin 15.3 µM -1.84383651617861 0.0222245444397448 no 3243 0.0326034846145937 4656 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_460 trequinsin 123 µM -1.84610620259764 0.0220949006549163 no 3244 0.0324383932106466 4711 5537 A vasodilator.
SGTC_2224 6650123 117.647 µM -1.855145278001 0.0215849068822939 no 3245 0.0317877417708049 4699 2908370
SGTC_1329 1447-1697 50.6 µM -1.8618406487536 0.0212135919251482 no 3246 0.0313127774737572 4644 2840515
SGTC_2215 7188065 200 µM -1.86294325752848 0.0211529640609168 no 3247 0.0312351249568347 4696 940217
SGTC_302 1094-0063 18.9 µM -1.86492566948862 0.0210443281505922 no 3248 0.0310959118956508 4652 5440289
SGTC_195 4234-0266 16.654 µM -1.87157274466421 0.0206835084662188 no 3249 0.0306328685284824 4672 2303354
SGTC_932 2857-0803 154 µM -1.87393341562533 0.0205566325551089 no 3250 0.0304698015279533 4635 674898
SGTC_3146 9095609 49.47 µM -1.88103388254129 0.0201789802827329 no 3251 0.0299836549552779 4663 17173999
SGTC_3334 9142812 21.919 µM -1.88851188546039 0.019787625186525 no 3252 0.0294786319174955 4638 45283678
SGTC_2301 7769476 200 µM -1.89211839603506 0.0196011960208902 no 3253 0.0292376039005098 4648 977820
SGTC_340 k038-0059 454 µM -1.89215450145905 0.0195993372119152 no 3254 0.0292351992263748 4645 23733424
SGTC_3352 9151559 45.5865 µM -1.89289412785698 0.0195612920889697 no 3255 0.0291859751640338 4647 17159339
SGTC_1795 st049545 62.3 µM -1.89885921321971 0.0192567447810116 no 3256 0.0287914946349114 4640 5291882
SGTC_3113 9123498 49.47 µM -1.90221407169271 0.0190872399101868 no 3257 0.0285715869615577 4724 8897275
SGTC_1748 st037455 53.6035 µM -1.90616495938804 0.0188892488933132 no 3258 0.0283144034494977 4646 580690
SGTC_2289 7946404 165.07 µM -1.91063471530567 0.0186673648181389 no 3259 0.028025769931933 4631 1246120 YPR165W RHO1
SGTC_1947 st076332 61.6 µM -1.93184738910148 0.0176443512767212 no 3260 0.0266891724995586 4551 24208416
SGTC_3356 9151811 4.48 µM -1.93906707603535 0.0173072633168533 no 3261 0.0262465855457013 4694 1859254 YPR165W RHO1
SGTC_1953 st076800 12.1 µM -1.93936647777181 0.0172934038281907 no 3262 0.0262283646892843 4627 297591
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.94228677274107 0.0171587180879749 no 3263 0.0260511967021515 4744 4620898
SGTC_2168 5727979 200 µM -1.94303572783903 0.0171243206051064 no 3264 0.0260059208331547 4602 695210
SGTC_1414 3917-0015 5.4 µM -1.94613425577526 0.0169826391115404 no 3265 0.0258193073388224 4682 6618702
SGTC_348 k064-0012 10.7 µM -1.94625048352626 0.016977344107569 no 3266 0.0258123292104772 4647 5066323
SGTC_1455 4262-0120 131 µM -1.95238236223029 0.0166999876546921 no 3267 0.025446412751236 4689 1529587
SGTC_472 calcifediol 10 µM -1.95353206931625 0.016648418112274 no 3268 0.0253782905506707 4705 5283731 A vitamin D metabolite.
SGTC_2417 cerulenin 830 nM -1.96170062140872 0.0162859303848354 no 3269 0.0248986747285142 4669 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2821 7996764 71.43 µM -1.96245131591745 0.0162529593133315 no 3270 0.0248549816689262 4628 2987135
SGTC_2085 5307070 144.047 µM -1.96813815342382 0.0160050413233147 no 3271 0.0245260719834408 4632 2840351
SGTC_414 piperonyl butoxide 100 µM -1.96973746088472 0.0159359061402893 no 3272 0.0244342336572853 4684 5794 A potent inhibitor of cytochrome P450.
SGTC_1292 0kpi-0043 232 µM -1.97212479547698 0.0158331823644297 no 3273 0.0242976810167793 4685 3333905
SGTC_1942 st076330 65.2 µM -1.97217085567489 0.0158312060531289 no 3274 0.0242950527433618 4685 24208414
SGTC_1118 chelidonine 707.474 nM -1.9762137972523 0.0156585572381686 no 3275 0.0240652839427999 4664 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2135 5326629 150.42 µM -1.98154539084258 0.015433349876391 no 3276 0.0237650721642403 4650 5020077
SGTC_2222 6885208 172.143 µM -1.98612139846655 0.015242281667007 no 3277 0.0235099228912048 4711 609514
SGTC_1587 estradiol valerate 56.1 µM -1.9881362693469 0.0151587984770668 no 3278 0.0233983105244075 4715 13791 A steroid.
SGTC_820 1582-0060 59.9 µM -1.9920238495852 0.014998832155319 no 3279 0.0231842205846787 4699 3848840
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.99517357582818 0.014870293175368 no 3280 0.0230119759770817 4678 23665772 A membrane-active detergent.
SGTC_1665 st014639 11.4 µM -1.9954979195121 0.01485711079794 no 3281 0.0229943004185156 4730 981133 YIL048W NEO1
SGTC_384 k007-0144 5.16 µM -1.99817755623457 0.0147485856274084 no 3282 0.0228487069322068 4660 6824886
SGTC_1220 1838-0075 193 µM -2.00095960531259 0.0146366349137933 no 3283 0.0226983716231993 4625 5529645
SGTC_2280 7785178 200 µM -2.00185810772613 0.0146006353864066 no 3284 0.0226499971503158 4677 2954328
SGTC_2783 7738165 71.43 µM -2.00491689490052 0.0144786522095482 no 3285 0.0224859661117384 4674 17201110
SGTC_2482 5981709 142.65 µM -2.01577386129021 0.0140527378919204 no 3286 0.0219118140073066 4652 877755
SGTC_121 0557-0495 61.343 µM -2.02144993090051 0.0138343980420912 no 3287 0.0216166052071661 4686 3104427
SGTC_1256 0570-0116 285 µM -2.03094191034972 0.0134758079641765 no 3288 0.0211304438288321 4675 410638
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -2.03562218009284 0.0133019690248481 no 3289 0.0208941544077009 4694 688667
SGTC_2344 7990960 76.95 µM -2.04756824400481 0.0128670139009762 no 3290 0.0203011618058247 4660 140813
SGTC_260 nsc-65238 3.989 µM -2.05585920237931 0.0125724211355421 no 3291 0.0198980447802077 4702 3246252
SGTC_1727 st034309 9.9045 µM -2.05774043769863 0.0125063960282962 no 3292 0.0198075281929902 4694 870305
SGTC_967 1306-0166 352 µM -2.06200409918588 0.0123578660098683 no 3293 0.0196036728547015 4693 4437607
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -2.06264049814051 0.0123358278265708 no 3294 0.0195733985130453 4672 6728940
SGTC_3290 9121031 71.43 µM -2.06858246327029 0.0121316981974573 no 3295 0.0192926424847397 4697 17014854
SGTC_2571 chrysanthemic acid 100 µM -2.06943757568058 0.0121025641017927 no 3296 0.0192525217502305 4674 2743 An insecticide.
SGTC_314 1671-0008 2.74 µM -2.09996837789198 0.0111013571137393 no 3297 0.0178658114630213 4593 3913060
SGTC_2468 5987765 72.9 µM -2.12194254759393 0.0104260745738589 no 3298 0.0169212814583144 4723 26772094
SGTC_1193 1488-0126 41.5 µM -2.14362085982615 0.00979525133818435 no 3299 0.0160316389921696 4699 1384710
SGTC_1520 flindersine 88 µM -2.14689388188797 0.00970296480720555 no 3300 0.0159008654036416 4700 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3000 9075062 71.4286 µM -2.14982336637126 0.0096210099092015 no 3301 0.0157845945850693 4703 17057871
SGTC_2814 7977482 42.97 µM -2.15514337823176 0.00947372398496763 no 3302 0.0155753080636435 4691 6456762
SGTC_229 benomyl 22.8748 µM -2.15653672467339 0.00943547615973982 no 3303 0.0155208896684953 4742 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2018 5133068 143 µM -2.15805746598682 0.00939388549985627 no 3304 0.0154616820845255 4687 785362
SGTC_3295 9122362 53.5725 µM -2.15883182858633 0.00937276918654596 no 3305 0.0154316081104455 4712 4730473
SGTC_1534 6-azauridine 81.6 µM -2.16686576028638 0.00915612807999321 no 3306 0.0151225457044645 4735 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1325 1431-0015 227 µM -2.17449400394965 0.00895449674923449 no 3307 0.0148340276107133 4718 1103340
SGTC_2219 9098279 200 µM -2.18040762876584 0.00880087380886327 no 3308 0.0146136295787323 4703 902349
SGTC_2187 6125751 200 µM -2.18117327322026 0.00878115394077075 no 3309 0.0145853014299697 4728 874498
SGTC_842 0271-0008 11.1 µM -2.18798374788478 0.00860744185031668 no 3310 0.0143353930874455 4721 1221709
SGTC_2005 4024620 188 µM -2.18917124366044 0.00857746346645425 no 3311 0.0142921979495355 4689 236743
SGTC_2709 st078560 56 µM -2.23764714599528 0.00742933724554177 no 3312 0.0126220372464535 4709 17250903
SGTC_1995 st072814 61.1 µM -2.24310121173548 0.00730904415186434 no 3313 0.0124451442809972 4735 5769371
SGTC_768 0384-0033 77.3 µM -2.2454681819662 0.00725737555612985 no 3314 0.0123690463146162 4707 3965305 YMR134W ERG29
SGTC_1951 sophoraflavanone G 9.2 µM -2.2545981074629 0.00706108299111656 no 3315 0.012079283179437 4682 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1516 st013856 110 µM -2.25662418773805 0.00701816304112804 no 3316 0.012015783830817 4725 5281404 A mutagen and neurotoxin.
SGTC_1955 wogonin 32.4 µM -2.26007387478869 0.00694561539006305 no 3317 0.011908333132476 4701 5281703 A flavanone.
SGTC_2264 7948757 110.76 µM -2.28888644003748 0.00636509093804859 no 3318 0.0110429756632659 4706 2971411
SGTC_380 3970-0968 6 µM -2.30018118257988 0.00614950773161869 no 3319 0.0107189787251566 4703 2891601
SGTC_2312 7706453 155.7 µM -2.33469553050397 0.005530273023516 no 3320 0.00977966596275466 4716 976098
SGTC_312 4092-0653 6.84 µM -2.36090293179884 0.00509774027479534 no 3321 0.00911525085666428 4664 1148278
SGTC_2629 bisabolol 100 µM -2.39875287759582 0.00452619500062264 no 3322 0.00822550647617318 4741 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1148 3909-7663 27.7 µM -2.40270230693045 0.00446998506227215 no 3323 0.00813721492218195 4759 4084526
SGTC_317 4495-0002 170 µM -2.40920805992724 0.00437875083088553 no 3324 0.00799359047599627 4750 15991618
SGTC_2371 9071574 200 µM -2.4673068261961 0.00363493832808005 no 3325 0.0068066826124554 4765 45596039
SGTC_3112 9123419 49.47 µM -2.4863261090072 0.00341732892735695 no 3326 0.00645348151519506 4777 17015854
SGTC_841 0251-0215 91.2 µM -2.48728556800714 0.00340666806430445 no 3327 0.00643610135024991 4781 3888614
SGTC_1952 st077036 64.1 µM -2.51798569625136 0.00308094178283941 no 3328 0.00590140570689623 4758 2937007
SGTC_3130 9127414 49.47 µM -2.53266992712656 0.00293529067123751 no 3329 0.0056598744321438 4773 1494646
SGTC_1181 1222-0449 220 µM -2.53583256061689 0.00290474514339098 no 3330 0.00560901785868809 4777 658318
SGTC_2178 5812956 200 µM -2.58209718173895 0.00248951059327508 no 3331 0.00491009638218397 4760 5403383
SGTC_1675 st018485 24.5 µM -2.59606147503615 0.00237517525696294 no 3332 0.00471495959346121 4753 3323024
SGTC_441 propafenone 146 µM -2.61044264238115 0.00226241433408288 no 3333 0.0045212567183069 4763 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_951 1171-0579 82.7 µM -2.63572340600156 0.00207588600217004 no 3334 0.00419790687814581 4733 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1818 st052136 56.3 µM -2.65676794911659 0.00193137894927718 no 3335 0.00394468636407549 4594 674169
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -2.65901165660951 0.00191652395769743 no 3336 0.00391851257366197 4745 6708514
SGTC_2195 6536160 144.242 µM -2.66513817901872 0.00187648909872945 no 3337 0.00384783473180857 4787 3834386
SGTC_2197 6588183 93.1375 µM -2.78828677968273 0.00121704117689114 no 3338 0.00264938073923665 4799 884136
SGTC_1725 st036284 20.55 µM -2.80133485455557 0.00116134725219215 no 3339 0.00254458407803341 4773 707914
SGTC_146 3448-8650 53.125 µM -2.82954544748033 0.00104882688843872 no 3340 0.00233070894905637 4768 2891488 YIL048W NEO1
SGTC_367 0335-0881 7.1 µM -2.83341618725259 0.00103419349233711 no 3341 0.00230266914816303 4743 23828853
SGTC_2529 gangaleoidin 93.61 µM -2.85250137163976 0.000964742229807171 yes 3342 0.0021688312614668 4777 4565183
SGTC_3029 9088683 49.47 µM -2.86959340733099 0.000906206574835424 yes 3343 0.00205499959669167 4787 25236615
SGTC_1035 k081-0041 55.2 µM -2.90247855826577 0.000802666688956201 yes 3344 0.00185111251362117 4789 731709
SGTC_334 1502-1024 68.5 µM -3.03704850542692 0.000482569229215477 yes 3345 0.00119453504082128 4793 3296216
SGTC_75 0159-0059 199.013 µM -3.04864309137449 0.000461441763178613 yes 3346 0.00114938704042615 4788 5377270
SGTC_1530 rhein 70.4 µM -3.06559626512235 0.000432088855747671 yes 3347 0.00108618216864145 4807 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_3134 9127454 49.47 µM -3.10862549649038 0.000365182099155264 yes 3348 0.000939799009418413 4792 24262820
SGTC_1837 st055472 66.5 µM -3.15010072141202 0.000309918493998575 yes 3349 0.000816070915818076 4796 676091
SGTC_2017 5132927 60.65 µM -3.28748939952581 0.00017754449098916 yes 3350 0.000505424973308905 4788 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2813 7971799 71.43 µM -3.29909857329521 0.000169218886684716 yes 3351 0.000484979223625518 4780 2234054
SGTC_2467 5474540 200 µM -3.58792284038186 4.88240238307251e-05 yes 3352 0.000166661446800178 4799 5413519
SGTC_2068 5226020 147 µM -3.62276369872068 4.17633163519129e-05 yes 3353 0.000145736036103847 4799 1810509
SGTC_2807 7945238 51.95 µM -4.07939245651948 4.75615013689496e-06 yes 3354 2.2576776250348e-05 4798 17148797
SGTC_68 0986-0284 82.829 µM -4.21408073497294 2.39637199429252e-06 yes 3355 1.25398784059899e-05 4789 423278 YIL048W NEO1
SGTC_673 1082-0474 110 µM -5.84589765028041 1.15815039390398e-10 yes 3356 2.51921890201254e-09 4808 3098046