SGTCid condition conc unit CMD1|YBR109C.score CMD1|YBR109C.strain.pval CMD1|YBR109C.strain.significant CMD1|YBR109C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_39 0986-0283 58.349 µM 18.722500147812 1.41818233704129e-69 yes 1 1.62276919573024e-78 2 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_81 0411-0046 9.971 µM 15.832476221834 2.41484520860417e-50 yes 2 9.28821596990569e-57 1 12925265 SGTC_1597 7-benzyloxygramine 47.5 µM 15.4334785025779 6.12335022673052e-48 yes 3 4.8736003410776e-54 7 260807 SGTC_467 ro 31-8220 72.8 µM 14.1115286312847 2.0772558103864e-40 yes 4 1.61255233013124e-45 2 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_390 dec-rvkr-cmk 16.7 µM 13.7776493250951 1.29971319939776e-38 yes 5 1.73700424668741e-43 1 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_582 0987-0078 156 µM 13.6732750821827 4.64168312703382e-38 yes 6 7.33217683891401e-43 1 1625765 SGTC_1712 st032288 53.4 µM 8.1982111044773 7.03340876809517e-15 yes 7 1.21995302817536e-16 6 2883011 SGTC_1317 1273-0028 910 nM 7.20471981403336 6.82648895771892e-12 yes 8 2.90816616739321e-13 5 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_121 0557-0495 61.343 µM 7.04620159592246 1.88961706905372e-11 yes 9 9.19339077778331e-13 3 3104427 SGTC_65 0798-0905 34.986 µM 7.01334351628653 2.32726637551544e-11 yes 10 1.1634459641438e-12 1 3602145 SGTC_502 l-744,832 89.3 µM 6.89747114677054 4.81560745319492e-11 yes 11 2.64681951797573e-12 1 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_314 1671-0008 2.74 µM 6.77198150478811 1.04465824612229e-10 yes 12 6.35151912176295e-12 2 3913060 SGTC_2021 4019055 173 µM 6.12701822406201 4.51119747979308e-09 yes 13 4.47706098898109e-10 18 44827708 YER133W GLC7 SGTC_528 3492-0019 172 µM 6.07314074917323 6.07920825128037e-09 yes 14 6.27162113619442e-10 7 2869262 SGTC_117 lucigenin 22.078 µM 5.79205914671272 2.76790060133364e-08 yes 15 3.47643231857134e-09 6 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_851 0394-0702 453 µM 5.64476382936622 5.96137989422225e-08 yes 16 8.27040748511317e-09 13 762646 SGTC_266 formosanin C 406 nM 5.60690477814847 7.23904550439754e-08 yes 17 1.02988453144462e-08 11 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_193 1273-0060 1.558 µM 5.56527127949625 8.94967777532239e-08 yes 18 1.30872445888409e-08 3 2847393 YHR072W ERG7 SGTC_2289 7946404 165.07 µM 5.5307356171353 1.06595229801165e-07 yes 19 1.59445322984341e-08 9 1246120 YPR165W RHO1 SGTC_2896 9052656 71.43 µM 5.40173021938104 2.02976127169335e-07 yes 20 3.30005809170725e-08 14 6469436 SGTC_1831 st055328 12 µM 5.32062319034186 3.02086894897327e-07 yes 21 5.17061976927155e-08 7 1103068 SGTC_1785 bathophenanthroline 24 µM 5.29737481964806 3.38204919050878e-07 yes 22 5.87396944823206e-08 10 72812 An iron chelator. SGTC_1666 st014829 29 µM 5.16079860796008 6.50533041867773e-07 yes 23 1.22949299206827e-07 2 3858230 SGTC_2036 5160441 105 µM 5.15996195038822 6.5311303451568e-07 yes 24 1.23500018556715e-07 15 134534 YIL048W NEO1 SGTC_2459 5811157 9.22 µM 5.05149788915025 1.08552819975393e-06 yes 25 2.1917939096972e-07 6 2870684 YBR192W RIM2 SGTC_1044 1222-0021 1.78 µM 4.89118879481846 2.25833704786901e-06 yes 26 5.01143840476107e-07 24 4306703 SGTC_1800 st050079 29.0735 µM 4.82917048705797 2.98071741043585e-06 yes 27 6.85514939908216e-07 14 3645560 SGTC_830 4076-0286 57.8 µM 4.8001446240931 3.39034856836494e-06 yes 28 7.92755451495131e-07 2 6866659 SGTC_299 1273-0059 1.44 µM 4.48962296559639 1.28554436492829e-05 yes 29 3.56746750634143e-06 7 2848077 SGTC_3050 9093513 49.47 µM 4.48358778019634 1.31821336873288e-05 yes 30 3.66991943965789e-06 5 25236664 SGTC_607 4491-0986 66.8 µM 4.47008793621511 1.39417075378591e-05 yes 31 3.90937219669362e-06 5 698981 YDR232W HEM1 SGTC_609 0986-0026 86.3 µM 4.37648079204698 2.04729279802101e-05 yes 32 6.03054073151255e-06 9 2848610 SGTC_33 0986-0033 35.816 µM 4.36330386762879 2.15978727987756e-05 yes 33 6.4056399600367e-06 2 2848082 SGTC_2475 5812728 15.03 µM 4.35803131840957 2.20642255681399e-05 yes 34 6.56188037341316e-06 14 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1803 st050068 52.4 µM 4.33655584848988 2.406424083658e-05 yes 35 7.2366332719809e-06 14 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1087 pterostilbene 9.05 µM 4.32213291737138 2.55026616606653e-05 yes 36 7.72640224399713e-06 3 5281727 Similar to reservatol, lowers cholesterol. SGTC_3196 9111891 49.47 µM 4.28967655967939 2.90432437463719e-05 yes 37 8.9466757639814e-06 1 18891510 SGTC_1841 st054148 70 µM 4.21740388807658 3.86706723390973e-05 yes 38 1.23565549363644e-05 3 675442 SGTC_1057 3448-5381 134 µM 4.15496350945587 4.93474432059644e-05 yes 39 1.62669730140863e-05 14 5497911 SGTC_2336 9001819 198.65 µM 4.15330789637477 4.96652654562519e-05 yes 40 1.63851665651948e-05 35 2989602 SGTC_3055 9094636 49.47 µM 4.14471089527048 5.13469066968828e-05 yes 41 1.70121348184361e-05 5 25236176 SGTC_373 0844-0104 25.9 µM 4.10497848525534 5.98411446582236e-05 yes 42 2.02176255502842e-05 10 5375804 SGTC_2326 6164455 177.58 µM 4.08495250538828 6.46087931921044e-05 yes 43 2.20429165788892e-05 12 2888790 SGTC_2640 pentamidine 10.38 µM 3.97130493561523 9.91865579611003e-05 yes 44 3.57400076259483e-05 16 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2225 6654152 15.4 µM 3.95488692807085 0.00010542837802887 yes 45 3.82854284199261e-05 25 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_513 4245-1575 41.7 µM 3.95355204761643 0.000105951766295745 yes 46 3.84997524379823e-05 29 719745 SGTC_992 3909-8734 162 µM 3.91771592322 0.000120949150566494 yes 47 4.46959815362171e-05 2 4288319 SGTC_400 oxethazaine 37.5 µM 3.87829649372546 0.000139735608498116 yes 48 5.2595234220729e-05 3 4621 A local anesthetic. SGTC_601 0986-0029 62.9 µM 3.87495211405703 0.000141449361071103 yes 49 5.33228344717455e-05 18 24747981 SGTC_1098 clofazimine 15.1 µM 3.8262463323251 0.000168747838767463 yes 50 6.50560468573597e-05 29 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_255 tunicamycin 200.472 nM 3.7121115897742 0.000253195222494204 yes 51 0.000102768663754332 16 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_457 grayanotoxin iii 135 µM 3.63626858171034 0.00032956748249128 yes 52 0.000138307960150792 23 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_3318 9139014 38.6185 µM 3.63186101475554 0.000334606111266637 yes 53 0.000140692332618767 14 16643984 SGTC_1622 st003707 19.4 µM 3.44802744531553 0.000621058775007503 yes 54 0.000282348326818065 8 10140899 SGTC_683 panaxydol 45 µM 3.44090156694669 0.000635768965506122 yes 55 0.000289889704360653 4 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_173 1273-0061 2.693 µM 3.44044999730505 0.0006367119078456 yes 56 0.000290373867311344 36 2847414 YPL266W DIM1 SGTC_1615 st002656 86.5 µM 3.38572588318571 0.00076103037398623 yes 57 0.000354951286618904 9 1584458 SGTC_187 1488-2104 32.728 µM 3.38112404010338 0.000772443351063941 yes 58 0.000360949733737622 13 2852859 SGTC_327 1273-0057 3.96 µM 3.37836931900257 0.000779350508915442 yes 59 0.000364585400185041 12 3108138 SGTC_2651 TUB2.036 5 µM 3.35075730916626 0.000851795263375421 yes 60 0.000402954491892658 55 15992207 YFL037W TUB2 SGTC_1201 1889-3372 45.9 µM 3.33507278633544 0.000895655297986064 yes 61 0.000426385375151301 11 5392199 SGTC_459 nigericin 15.3 µM 3.30313051471521 0.00099146334138694 yes 62 0.000478059382328756 15 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_320 4092-0846 5.34 µM 3.30145550360721 0.000996737964844435 yes 63 0.000480922949589087 33 1359356 SGTC_1279 0874-0590 65.2 µM 3.24788930084955 0.00117962373084393 no 64 0.000581322472058683 4 3523074 SGTC_500 h-89 112 µM 3.16891802553125 0.00150568874167176 no 65 0.000765037715705093 18 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2066 5222451 176 µM 3.16312355299642 0.00153258532455188 no 66 0.000780430363857264 39 2281147 SGTC_1178 0988-0033 191 µM 3.14178584675163 0.00163545031377479 no 67 0.000839604036990013 12 5392207 SGTC_2902 5787006 60.46 µM 3.12862399909762 0.00170199805396809 no 68 0.000878134448449699 11 591003 SGTC_2727 riluzole 51.77 µM 3.08681000771185 0.00193009840577765 no 69 0.00101158431274029 13 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_3204 9114183 49.47 µM 3.07030025224697 0.00202756339081977 no 70 0.00106921836771943 16 17027248 SGTC_2208 7283366 200 µM 3.0683265888431 0.00203950901285714 no 71 0.00107630611166405 2 898663 SGTC_2313 7726885 200 µM 3.03082129186213 0.00227899103996862 no 72 0.00121944776016076 18 726423 SGTC_1793 st048256 72.231 µM 2.9904079561755 0.00256530808366429 no 73 0.00139302540272332 11 672022 SGTC_2835 9006588 71.43 µM 2.98172530401687 0.0026309125410165 no 74 0.00143314527114971 19 2345538 SGTC_853 0419-0306 21 µM 2.97441205798688 0.00268734178453957 no 75 0.00146775292875056 26 762713 SGTC_1479 0549-0158 134 µM 2.9690807816267 0.0027291643639131 no 76 0.00149346031375794 17 5440202 SGTC_3216 9129716 49.47 µM 2.96058993013584 0.00279698716607917 no 77 0.00153525232037374 12 8056934 SGTC_766 1391-0721 126 µM 2.95922645899301 0.00280801883668502 no 78 0.00154206184863213 14 1020919 YIL115C NUP159 SGTC_148 3253-0744 288.01 µM 2.95545238355994 0.00283875939982081 no 79 0.00156105443194137 18 6893655 SGTC_2659 sanguinarine 24.21 µM 2.93915517567032 0.00297501812514301 no 80 0.00164554127520308 20 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2290 7904846 200 µM 2.91946663468577 0.00314747546365541 no 81 0.00175315463313598 30 2962154 SGTC_1377 2944-0135 198 µM 2.90356959734232 0.00329323187803641 no 82 0.00184467480135123 22 1894137 SGTC_852 0418-0143 439 µM 2.8899606988162 0.00342280062544541 no 83 0.00192644995902974 28 5369229 SGTC_123 0083-0120 66.675 µM 2.86316741856392 0.00369135970984756 no 84 0.00209714439797071 30 16001701 SGTC_1773 st048542 73.5835 µM 2.86031194423108 0.00372106777226901 no 85 0.00211612239309643 50 3237138 SGTC_2139 5578692 56.4705 µM 2.85727853809464 0.00375286175141253 no 86 0.00213645346814032 34 650991 YMR113W FOL3 SGTC_679 0422-0091 41.4 µM 2.82581926635157 0.00409724409587208 no 87 0.00235799323473431 28 627384 YHR062C RPP1 SGTC_1835 st008666 49.2 µM 2.81600640320903 0.00421030835810183 no 88 0.00243123487682772 7 690455 SGTC_2882 9058044 58.44 µM 2.81399437245643 0.00423383291343741 no 89 0.00244650424679248 23 18076804 SGTC_908 3448-7491 47.7 µM 2.81373956222825 0.00423682051117335 no 90 0.00244844418650282 22 1203031 SGTC_1031 k035-0009 16 µM 2.80209770439819 0.00437534573417731 no 91 0.00253857473283382 12 5180959 SGTC_168 3970-0862 530.542 µM 2.80080220377155 0.00439100832100456 no 92 0.00254878765203067 75 3135186 SGTC_312 4092-0653 6.84 µM 2.80041062425235 0.00439575236225013 no 93 0.00255188192191425 52 1148278 SGTC_2344 7990960 76.95 µM 2.79311380349067 0.00448499610596122 no 94 0.0026101661298418 61 140813 SGTC_2566 crystal violet carbinol 226 nM 2.79175059739812 0.00450184704667147 no 95 0.00262118729821926 48 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_3046 9092212 49.47 µM 2.77606351951605 0.00469986697326682 no 96 0.0027510728913468 11 25236637 SGTC_252 miconazole 1.30953 nM 2.7668388062426 0.00481990628618663 no 97 0.00283013674243398 37 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2257 7960413 200 µM 2.7620716308136 0.00488300555418115 no 98 0.00287179379501726 38 2974689 YIL048W NEO1 SGTC_842 0271-0008 11.1 µM 2.75828076581341 0.00493370656132848 no 99 0.0029053133369908 35 1221709 SGTC_2030 5175110 200 µM 2.75034831673832 0.00504131952624377 no 100 0.00297659731160361 15 2831986 SGTC_862 0452-0056 10.2 µM 2.74055693248422 0.00517703031829412 no 101 0.00306675774211732 8 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1789 tunicamycin 25 nM 2.71431488262162 0.00555691785182025 no 102 0.00332065031929524 38 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1099 5-nonyloxytryptamine 2.85 µM 2.70251249856844 0.00573570205907707 no 103 0.00344087985416868 26 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_584 0986-0246 15.4 µM 2.69126673347779 0.00591078548833435 no 104 0.00355906289578303 57 53315 YDR232W HEM1 SGTC_2406 ethylparaben 405.7 µM 2.68664992583708 0.00598402537839242 no 105 0.00360862751759325 23 8434 A possible steroid mimic. SGTC_2000 st075254 36.4 µM 2.67817454438185 0.00612057333022039 no 106 0.00370123160216144 13 17234175 SGTC_1230 0170-0365 3.77 µM 2.67735942443501 0.00613385024282485 no 107 0.00371024920828797 41 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1310 1188-0297 994 nM 2.66767888731973 0.00629349161306766 no 108 0.00381886087143643 29 1588352 SGTC_2067 5224629 34.075 µM 2.66374257450038 0.00635945008558875 no 109 0.00386383369065454 26 2835000 SGTC_628 1636-0253 16 µM 2.66312509138431 0.00636985221526111 no 110 0.00387093140918096 36 4456143 SGTC_2799 7812892 81.82 µM 2.65163195914626 0.00656623344081093 no 111 0.00400519023255994 40 20205235 SGTC_1380 2291-0730 164 µM 2.64381959932463 0.00670276026532219 no 112 0.00409881670807544 14 2999191 SGTC_2089 5281248 129.67 µM 2.64250748922291 0.00672593480642851 no 113 0.00411473226446678 29 2737878 SGTC_384 k007-0144 5.16 µM 2.64226764270625 0.00673017863124472 no 114 0.00411764751179108 46 6824886 SGTC_2766 oltipraz 83.91 µM 2.63845595140182 0.00679794071298831 no 115 0.00416422596951591 38 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1261 0712-0010 12.7 µM 2.62267357733783 0.00708496743056346 no 116 0.0043621407319785 30 2840123 SGTC_2994 9053520 71.4286 µM 2.61886507849897 0.00715581230040003 no 117 0.00441114167108152 24 4647384 SGTC_2915 7971052 15.16 µM 2.61562713703863 0.00721653451110106 no 118 0.00445318784877169 14 5741558 SGTC_539 4859-0462 2.54 µM 2.6118327256302 0.00728827029309888 no 119 0.00450291531741264 40 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2365 9042475 200 µM 2.60778170271033 0.00736555068586225 no 120 0.00455655254082874 20 6464479 SGTC_2156 5649887 115 µM 2.58191452539005 0.00787625871214684 no 121 0.00491269580876073 37 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2038 4100038 30.985 µM 2.58145770885421 0.00788555102654083 no 122 0.00491920224429559 41 3596803 SGTC_1323 1348-1351 11.2 µM 2.57591845180237 0.00799899729941894 no 123 0.00499871108715788 19 6989654 SGTC_208 k072-0098 12.366 µM 2.56301782461769 0.00826878593416123 no 124 0.00518833605449864 46 5948901 SGTC_1506 4226-2149 212 µM 2.56006092305835 0.0083317374213498 no 125 0.00523269075721469 32 991114 SGTC_150 3970-0969 77.2 µM 2.5549057606812 0.00844249602185353 no 126 0.00531082754459007 56 6615640 SGTC_2614 arthonioic acid 13.39 µM 2.55385009429055 0.00846533575644322 no 127 0.00532695569022086 17 6710684 SGTC_120 rhodamine 6G 52.259 µM 2.55008734327948 0.00854718598138094 no 128 0.00538479670768515 66 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1075 aripiprazole 15.2 µM 2.5411623533797 0.00874411142690831 no 129 0.00552423012555697 22 60795 An atypical antipschotic. YIL048W NEO1 SGTC_324 1315-0088 19.6 µM 2.53428821089696 0.00889848666734707 no 130 0.00563380077689379 41 6787421 SGTC_801 0866-0028 10.1 µM 2.5254245496817 0.00910106286459399 no 131 0.00577792962524938 30 6849771 SGTC_2471 5466956 24.79 µM 2.5247736037407 0.00911609795452328 no 132 0.00578864227740017 44 724419 SGTC_1113 artemisinin 1.17947 µM 2.52459550845486 0.00912021526077368 no 133 0.00579157626995094 54 2240 An anti-malaria and mitochondrial poison. SGTC_3317 9138495 8.753 µM 2.52385255982913 0.00913740872996826 no 134 0.00580383005657035 37 17020139 SGTC_2914 7968218 45.32 µM 2.52107164648681 0.00920201735065942 no 135 0.00584990136396767 16 2977111 SGTC_1850 st056238 17 µM 2.51988192381336 0.0092297799337488 no 136 0.00586971035013689 24 5393177 SGTC_2983 9022671 12.99 µM 2.51896786739518 0.0092511595202199 no 137 0.00588496986214545 23 6405161 SGTC_1614 st002383 48.6 µM 2.49352467718488 0.00986391864017691 no 138 0.00632408960230744 14 1947235 SGTC_2857 9024691 58.44 µM 2.48869206308666 0.00998422778369652 no 139 0.00641069818325761 24 16478292 SGTC_902 1120-0002 2.07 µM 2.47881757690293 0.0102340439491993 no 140 0.00659093524975494 37 3280475 SGTC_2947 9072639 7.68 µM 2.46861628421385 0.0104978361644838 no 141 0.0067818287464226 36 16488146 SGTC_355 1311-2252 105 µM 2.45998623541247 0.0107256049417702 no 142 0.00694711722430044 25 5338538 SGTC_2016 5121758 140 µM 2.45851002009197 0.0107649939712404 no 143 0.00697574416118982 54 2795203 SGTC_2451 5856223 45.7 µM 2.45401172095442 0.01088579714824 no 144 0.00706361883280753 39 2179896 SGTC_3100 9120536 49.47 µM 2.4527608681493 0.0109195981207462 no 145 0.00708822729759072 23 16421196 SGTC_1246 0422-0085 105 µM 2.4476093789082 0.0110597678058624 no 146 0.00719037343977523 36 264295 SGTC_745 0469-0705 296 µM 2.41787668835624 0.0118997520181557 no 147 0.00780568312291633 62 3486736 SGTC_2341 7987486 176.74 µM 2.41508471682907 0.0119813995116294 no 148 0.00786577512833847 32 1258686 SGTC_103 0844-0104 51.839 µM 2.39071839883127 0.0127148176186717 no 149 0.00840772237089441 94 5375804 SGTC_2778 tioconazole 65.09 nM 2.37782382368937 0.0131184299813722 no 150 0.00870757212396936 73 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2928 9011484 9.79 µM 2.3755396290362 0.0131910701601561 no 151 0.00876165530522522 65 2994751 SGTC_2845 9003024 42.97 µM 2.37015249294429 0.0133637653930099 no 152 0.00889037498781041 43 2990173 SGTC_214 4373-3496 70 µM 2.36989182611125 0.0133721708761518 no 153 0.00889664514893305 59 3779166 SGTC_2930 9013230 14.89 µM 2.36476564098842 0.0135384004072754 no 154 0.00902074181939967 58 2995857 SGTC_2408 sulbentine 18.36 µM 2.36311785147716 0.0135922116058706 no 155 0.00906095286301301 65 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1621 st003705 32.4 µM 2.35117283081064 0.0139878427284832 no 156 0.00935716955783269 36 24207032 SGTC_1247 0448-0043 5.84 µM 2.34749866765288 0.0141115140582824 no 157 0.00944997037552343 40 3089013 YGL099W LSG1 SGTC_1638 st008370 60.6 µM 2.31905259747834 0.0151012815420462 no 158 0.0101960922852621 46 24207134 SGTC_2519 cryptotanshinone 88.04 µM 2.31665518427424 0.0151873599661134 no 159 0.0102612613433854 57 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2634 4'-methoxyflavone 100 µM 2.3162024142623 0.0152036637753575 no 160 0.0102736097200431 32 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_2712 st079126 47.7 µM 2.31167223645015 0.0153676205808318 no 161 0.0103978762491505 28 3152970 SGTC_1256 0570-0116 285 µM 2.29657755110288 0.0159249318448534 no 162 0.0108214402424138 43 410638 SGTC_3093 9117344 49.47 µM 2.29506029254234 0.0159818972542418 no 163 0.010864834626005 40 24824913 SGTC_439 amiodarone 34.4 µM 2.28608031029617 0.0163226388729105 no 164 0.0111247803270418 34 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2696 st077691 74.316 µM 2.27613042946438 0.016707430432257 no 165 0.0114191021501217 50 757133 SGTC_1899 st063254 59.6 µM 2.27414906502742 0.0167849753265778 no 166 0.0114785127530619 29 3093813 SGTC_2582 agaric acid 100 µM 2.26133924222388 0.0172937807734385 no 167 0.011869128987092 67 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_3315 9136395 68.55 µM 2.26084849528258 0.0173135324477948 no 168 0.0118843202031037 54 16876844 SGTC_912 3474-0017 2.18 µM 2.25808231957188 0.0174252267794587 no 169 0.0119702638529669 35 3360550 SGTC_2223 6903751 107.57 µM 2.24977106537499 0.0177645324825373 no 170 0.012231740832041 35 5598863 SGTC_733 4069-0007 56.1 µM 2.24704928133839 0.0178768671719573 no 171 0.0123184388831373 52 5717425 YNL287W SEC21 SGTC_352 k048-0007 5.11 µM 2.24357294093957 0.0180212248643525 no 172 0.012429945944423 58 6811911 SGTC_2237 6667747 47.222 µM 2.23972152935905 0.0181823170179209 no 173 0.012554503486615 26 729940 YDL015C TSC13 SGTC_1076 itraconazole 331 nM 2.23863247515635 0.0182280906197813 no 174 0.0125899197005499 41 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_16 erodoxin 22.806 µM 2.23817644403962 0.0182472870292875 no 175 0.0126047755736912 72 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_563 tetrahydrosecaminediol 614 µM 2.23811936538802 0.0182496909400885 no 176 0.012606636061312 27 334274 A psychoactive constituent of the cannabis plant. SGTC_1257 0669-0121 16 µM 2.22805866558458 0.0186776418466109 no 177 0.0129383015871387 32 4307855 SGTC_1062 mesoridazine 14.2 µM 2.21915766642758 0.0190633553453548 no 178 0.0132379999956948 38 4078 A neuroleptic. SGTC_817 1391-0715 46 µM 2.20935553488222 0.0194959341574155 no 179 0.0135749606229833 61 1353946 SGTC_3048 9093155 49.47 µM 2.20853077311169 0.0195327091056085 no 180 0.0136036475418315 31 25236002 SGTC_1403 3909-7815 62.9 µM 2.18764788298811 0.0204836686670461 no 181 0.0143476305438979 32 6615483 SGTC_2949 9072542 2.23 µM 2.1875240257279 0.0204894238380287 no 182 0.014352145633764 54 16457352 SGTC_1016 4226-1401 38 µM 2.18581729693426 0.0205688685889618 no 183 0.0144144873912835 51 2901613 SGTC_335 4077-0256 27.6 µM 2.18151049664744 0.020770502234969 no 184 0.0145728394678499 54 3121989 SGTC_2019 4016004 108 µM 2.18025041201894 0.0208298117852058 no 185 0.0146194523106823 51 45595336 SGTC_184 1494-0393 24.714 µM 2.17180157174222 0.0212311959553701 no 186 0.0149353165449456 91 3090647 SGTC_2056 5235370 200 µM 2.16343070448622 0.0216353080239819 no 187 0.0152540340597773 42 5511916 SGTC_310 1273-0058 1.06 µM 2.15184927884521 0.022205114538067 no 188 0.015704613583503 23 2734232 SGTC_3350 9150499 3.57 µM 2.14177983726185 0.0227107732613461 no 189 0.0161056013303267 45 4910996 YPR165W RHO1 SGTC_197 4544-0043 41.561 µM 2.14048615265693 0.0227764365513442 no 190 0.0161577493483032 74 896523 SGTC_1672 st016598 6.51 µM 2.12905023411384 0.0233638751260825 no 191 0.0166250522510364 61 4665860 YNL267W PIK1 SGTC_1371 2421-0008 32.7 µM 2.12303521743587 0.0236779366919099 no 192 0.0168754504229547 73 2827552 SGTC_3327 9140648 26.9345 µM 2.11828797709058 0.0239283037133279 no 193 0.0170753431172235 79 8029710 SGTC_754 3474-0146 171 µM 2.11557284740255 0.0240724957979511 no 194 0.0171905765993466 44 24762078 SGTC_2366 9070441 60.58 µM 2.11268971959154 0.0242264081964778 no 195 0.0173136668899286 37 6837235 SGTC_85 0868-0259 160.055 µM 2.11115381898194 0.0243087373109844 no 196 0.0173795463843752 35 83173 SGTC_1941 st076221 61.8 µM 2.10988928674938 0.0243766964428593 no 197 0.0174339466284508 49 2828568 SGTC_2412 st077135 33.4 µM 2.10803231117451 0.0244767840287274 no 198 0.0175140973230015 43 13258915 SGTC_1690 st023502 41.2 µM 2.09889249844845 0.0249744436125208 no 199 0.0179131891435034 41 24207482 SGTC_1898 st060199 18.6 µM 2.09630232856965 0.0251170105827138 no 200 0.0180276901605484 47 688866 SGTC_2797 7859098 81.82 µM 2.08934761904324 0.0255031868185422 no 201 0.0183382213767841 45 972681 SGTC_788 1182-0090 188 µM 2.08589740182786 0.0256966057750692 no 202 0.0184939588504339 55 5715185 SGTC_1480 1070-0044 41.2 µM 2.07938244696307 0.0260651825978583 no 203 0.0187911062775784 42 3124987 SGTC_949 1165-0505 146 µM 2.07805910305042 0.0261405871781568 no 204 0.0188519579168326 33 6244267 SGTC_1165 k072-0275 30.3 µM 2.07609513652366 0.0262528308365524 no 205 0.0189425764510482 55 6153523 YGL055W OLE1 SGTC_2054 5233173 129 µM 2.0528071110059 0.0276147634397557 no 206 0.0200456443043476 18 6889 SGTC_834 0312-0008 75.7 µM 2.05150149049013 0.027692830782737 no 207 0.0201090673160126 48 6385573 YIL048W NEO1 SGTC_1812 st052057 4.327 µM 2.03590258621076 0.0286398484515778 no 208 0.0208800690441781 56 3645418 SGTC_2330 7979373 200 µM 2.03539430154458 0.0286711542779994 no 209 0.0209056071290981 61 1863007 SGTC_3099 9120367 49.47 µM 2.03320948632642 0.0288060437463252 no 210 0.0210156815321765 39 24824940 SGTC_988 1497-1057 103 µM 2.02416119165312 0.0293703104502467 no 211 0.0214767845931635 47 3533044 SGTC_104 0074-0074 590.992 µM 2.01937924783566 0.029672208449557 no 212 0.021723908386101 65 3943124 SGTC_395 anisomycin 6.25 µM 2.01692590929242 0.0298280915856842 no 213 0.021851622894396 50 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2654 protoveratrine a 100 µM 2.01619276043518 0.0298748068954498 no 214 0.0218899115831849 51 5702278 A heart drug and vasodilator. SGTC_293 4049-0273 38.5 µM 1.99094210575722 0.0315211606248058 no 215 0.0232436262180477 48 1380311 SGTC_757 1066-0008 322 µM 1.98719321345697 0.0317718671802052 no 216 0.0234504948181334 47 6842497 SGTC_2575 plumbagin 510 nM 1.97687313633563 0.032470541505802 no 217 0.0240279860278439 79 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.97636522006868 0.0325052523861456 no 218 0.0240567138600288 55 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1069 diphenylcyclopropenone 8.49 µM 1.97436674514602 0.0326421249804257 no 219 0.0241700282533366 64 65057 A dermal irritant. YDR527W RBA50 SGTC_910 3454-3003 490 µM 1.97060307611749 0.0329011835099026 no 220 0.0243846472564617 67 820824 SGTC_1872 amphotericin b 148 nM 1.96759706632234 0.0331093064786102 no 221 0.0245572087804583 54 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_87 0100-0052 35.5 µM 1.95986868361609 0.0336493689664947 no 222 0.0250055703893653 84 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.95781527691801 0.0337940745889582 no 223 0.0251258460776557 41 4213774 SGTC_1931 st074438 57.1 µM 1.95268156841908 0.0341580932672137 no 224 0.0254286695241612 82 2787313 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 1.94193734156541 0.0349303766834822 no 225 0.0260723430768054 59 94937 An inhibitor of serotonin biosynthesis. SGTC_1382 3002-2117 298 µM 1.93876668356481 0.0351609997782274 no 226 0.0262648773297247 49 1497314 SGTC_2430 5571206 200 µM 1.93874352446743 0.0351626888784098 no 227 0.0262662879978914 76 1731771 SGTC_1710 st031758 61.5 µM 1.92727009624646 0.0360077223351735 no 228 0.0269729891396148 51 5394341 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.92493300591163 0.0361818752963488 no 229 0.0271188700313843 50 229346 A bile salt which induces apoptosis. SGTC_1207 2099-0101 141 µM 1.92319720895284 0.0363116675058328 no 230 0.0272276438280936 53 5837381 SGTC_3209 9113616 49.47 µM 1.92298459737893 0.0363275914573775 no 231 0.0272409921284851 66 16649353 SGTC_2315 7733312 200 µM 1.92156706502698 0.0364339064164619 no 232 0.0273301280457791 65 726316 SGTC_2841 9004761 38.96 µM 1.92117926979639 0.0364630353830041 no 233 0.0273545553493026 45 2991039 SGTC_1155 4088-0394 48.2 µM 1.9132981118422 0.0370591636361627 no 234 0.0278549496622847 62 2326248 SGTC_1432 4049-0298 68.4 µM 1.9087547824083 0.037406423915859 no 235 0.0281468662446644 46 741646 SGTC_2700 st077718 96.8 µM 1.89914231548251 0.0381498956115751 no 236 0.0287728833575074 52 904970 SGTC_3154 9100113 49.47 µM 1.89720897581988 0.0383008750557333 no 237 0.0289001813407608 66 25237525 SGTC_2443 5493264 126.67 µM 1.88992648109662 0.038873963042077 no 238 0.0293838966712337 44 5340055 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.88490600344692 0.0392730961114393 no 239 0.0297212647241362 54 5377381 SGTC_1556 plumbagin 1.48 µM 1.88271211474962 0.0394485564661094 no 240 0.029869696376882 77 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2316 5844804 197.44 µM 1.88226922398038 0.039484054732606 no 241 0.0298997354537566 80 776813 SGTC_2962 9082311 13.18 µM 1.88139488685579 0.0395542102637831 no 242 0.0299591109507475 76 16459453 SGTC_804 1595-0054 20.9 µM 1.87809567469814 0.0398198478007582 no 243 0.0301840389694945 54 761523 Stimulates phospholipase C. SGTC_2015 5119600 184 µM 1.87736621043993 0.0398787762794466 no 244 0.0302339596396371 74 2828786 SGTC_2473 5854593 8.94 µM 1.87705897821519 0.0399036166958286 no 245 0.0302550054563331 54 2872951 SGTC_2598 perillyl alcohol 100 µM 1.8757166324348 0.0400122959215615 no 246 0.0303471003964657 71 10819 An apoptosis inducer. SGTC_1161 k007-0610 110 µM 1.87435850437415 0.0401224975769117 no 247 0.0304405144054651 96 5843850 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.86990030631968 0.0404859804588088 no 248 0.0307488316370896 48 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1920 st075728 45.7 µM 1.8665120430649 0.0407640143691703 no 249 0.0309848803648476 65 3400306 SGTC_1691 st019933 84.6 µM 1.86055146017981 0.0412568863423448 no 250 0.031403772472645 57 6176082 SGTC_1239 0337-0584 35.4 µM 1.85813247185993 0.0414582821547816 no 251 0.031575102293321 93 914301 YML130C ERO1 SGTC_1545 lovastatin 49.4 µM 1.85497603283638 0.0417222725159784 no 252 0.0317998245930406 75 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_966 1300-0360 30.2 µM 1.85432003806985 0.0417773074860784 no 253 0.0318466935076361 75 70588 SGTC_2269 7935389 174.42 µM 1.84531981850758 0.0425383379040442 no 254 0.0324955145980728 63 97605 SGTC_1036 k216-0215 33.5 µM 1.82590485589514 0.0442181909881608 no 255 0.0339322973177199 51 622330 SGTC_1 0258-0098 57.368 µM 1.82442343627518 0.0443485342595832 no 256 0.0340440407778645 75 6790032 YDR047W HEM12 SGTC_2827 7993847 71.43 µM 1.82105405487331 0.0446461436589712 no 257 0.0342993202066227 52 2985692 SGTC_177 1327-0068 8.361 µM 1.81324329991225 0.0453422370249324 no 258 0.03489715207912 84 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_549 1661-1316 519 µM 1.80943248197884 0.0456850112441659 no 259 0.0351919203411425 77 2857282 SGTC_1415 3966-0071 78.1 µM 1.80625564443596 0.0459723497218035 no 260 0.0354392083882487 66 2893185 SGTC_570 0987-0065 62.6 µM 1.80313388547058 0.0462561191024431 no 261 0.0356835953013486 58 3104428 SGTC_234 nsc-17383 10.7 µM 1.80284129401362 0.046282787740386 no 262 0.0357065714495151 76 408974 SGTC_1807 st050092 58.9 µM 1.79548007849763 0.0469578073667385 no 263 0.036288621987906 63 5008496 SGTC_1698 5-fluorocytosine 1.055 µM 1.79300909377178 0.0471861572559201 no 264 0.0364857350017481 76 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2263 7948595 193.29 µM 1.79250461934586 0.0472328862373256 no 265 0.0365260849480324 57 2971371 SGTC_1131 3454-3128 32.3 µM 1.79206419486346 0.0472737126539605 no 266 0.0365613417608244 73 710982 SGTC_1718 roemerine 11.9335 µM 1.79028029739606 0.0474393655304673 no 267 0.0367044310149112 82 235224 An aporphine alkaloid with mutagenic activity. SGTC_1687 st020778 55.3625 µM 1.78491887967153 0.0479400280290258 no 268 0.0371372379156574 64 4259299 SGTC_63 0099-0242 26.702 µM 1.77427276642172 0.0489467220722137 no 269 0.0380090214955489 94 3898502 YLR359W ADE13 SGTC_2308 7584454 197.62 µM 1.77118728072747 0.0492416207382447 no 270 0.0382647818293194 86 893577 SGTC_2645 abamectin 100 µM 1.76862726614197 0.0494873723658982 no 271 0.0384780487235262 71 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2661 dactinomycin 12.96 µM 1.76837333900975 0.0495118016739051 no 272 0.0384992553172335 53 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2510 benzyl isothiocyanate 8.31 µM 1.76436563463494 0.0498986429963224 no 273 0.0388352200474609 107 2346 DNA damaging agent; causes G2/M arrest. SGTC_924 2046-0044 21.3 µM 1.76293210247491 0.0500375977799352 no 274 0.0389559709420878 76 3623589 SGTC_1073 triclabendazole 3.09 µM 1.75915751729369 0.0504049510039655 no 275 0.0392753788751536 65 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2533 agelasine 13.65 µM 1.75797680675332 0.0505203012871232 no 276 0.0393757278687009 82 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2968 9090663 33.37 µM 1.75646066708815 0.0506687298274366 no 277 0.0395048909124642 112 25236811 SGTC_566 0958-0068 16.5 µM 1.74713960045402 0.0515888987144977 no 278 0.040306562833794 79 6815365 SGTC_298 1391-0729 10 µM 1.74573777476307 0.0517284281527856 no 279 0.0404282639681509 63 3237558 SGTC_1781 st038725 66.3 µM 1.74492012317776 0.0518099507647576 no 280 0.0404993870031599 77 4270275 YIL048W NEO1 SGTC_3274 9138298 49.47 µM 1.74391648059159 0.0519101568611747 no 281 0.0405868272086175 82 17015756 SGTC_2688 kanamycin b 96.69 µM 1.73557027584606 0.0527494390665015 no 282 0.041319922746233 110 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1645 Cervolide 78 µM 1.72510482138023 0.0538170033382523 no 283 0.0422542919113553 76 23173 A fragrance. SGTC_2046 4110841 106 µM 1.72441390765216 0.0538880800501347 no 284 0.0423165743211083 87 44119630 YMR134W ERG29 SGTC_2499 avocadenofuran 51.48 µM 1.72279607645888 0.0540548027883119 no 285 0.0424627042805745 61 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_286 k060-0067 22.9 µM 1.72241281872457 0.0540943584935394 no 286 0.0424973816097582 81 5985051 SGTC_921 1561-0023 372 µM 1.72190045693538 0.0541472747002588 no 287 0.0425437761015457 83 24050882 SGTC_2251 lansoprazole 556 µM 1.71146191758049 0.0552343011201922 no 288 0.043497937750168 56 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1012 4112-3522 18 µM 1.70776725530192 0.0556231522563607 no 289 0.0438397685826984 63 3112398 SGTC_1434 4073-0095 163 µM 1.70711476454493 0.0556920487263046 no 290 0.0439003616856036 69 24133745 SGTC_68 0986-0284 82.829 µM 1.70328873669467 0.0560973950417268 no 291 0.0442570236855374 68 423278 YIL048W NEO1 SGTC_1400 3771-8998 51.5 µM 1.69675004982719 0.0567955142874676 no 292 0.044871962949155 37 670767 SGTC_2525 harmine 47.85 µM 1.69666853959125 0.0568042599172507 no 293 0.0448796718750039 62 5280953 A monoamine oxidase inhibitor SGTC_2051 5263410 176 µM 1.69243395361291 0.0572600699058616 no 294 0.0452816315376141 74 227584 SGTC_471 1-acyl-paf 4 µM 1.67853508673754 0.0587763921382631 no 295 0.0466213434056783 75 16759367 SGTC_980 1473-0395 201 µM 1.66940911269707 0.0597890256898517 no 296 0.0475181644542019 69 768876 SGTC_235 0330-0087 5 mM 1.66789724653762 0.0599580968300133 no 297 0.0476680631873494 72 46494818 YHR062C RPP1 SGTC_3218 9131285 49.47 µM 1.66780570844653 0.0599683454924507 no 298 0.0476771511647352 79 17156417 SGTC_409 arachidonic acid 100 µM 1.66732989893482 0.0600216395267274 no 299 0.0477244122805822 69 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_674 0498-0004 451 µM 1.65824953912971 0.0610458279375712 no 300 0.0486335547392445 115 4231473 SGTC_2380 9035439 200 µM 1.65782491914854 0.0610940537919166 no 301 0.0486764050269936 66 6462575 SGTC_2960 9079389 5.97 µM 1.65492765566802 0.0614239031849106 no 302 0.048969586804282 63 16457355 SGTC_2746 daunorubicin 9.88 µM 1.65405309870785 0.0615237431234275 no 303 0.0490583622185181 43 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2560 caryophyllene 100 µM 1.65174464418321 0.0617878864732227 no 304 0.0492933087715642 86 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2151 5563267 85.4165 µM 1.64928991798997 0.0620697371763016 no 305 0.0495441270673675 91 5310824 SGTC_1171 0368-0077 21.4 µM 1.64772829760152 0.0622495632368533 no 306 0.0497042192472774 91 3239779 SGTC_571 k831-0106 44.2 µM 1.64380208816196 0.0627034752043079 no 307 0.0501085449505403 88 4783639 SGTC_2935 9038016 29.96 µM 1.64201008431755 0.0629115055706229 no 308 0.0502939571086851 77 6463195 SGTC_2717 st081029 62.2815 µM 1.63928136090666 0.0632293102163541 no 309 0.0505773380179685 71 5292846 SGTC_2725 haloperidol 53.21 µM 1.63839435731247 0.0633328851233734 no 310 0.0506697277449133 103 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3030 9087619 49.47 µM 1.63559273544302 0.0636608964893873 no 311 0.0509624258876105 93 25236973 SGTC_797 k781-0471 270 µM 1.63460199708086 0.063777207074303 no 312 0.0510662543691968 90 23738129 SGTC_1453 4237-0541 195 µM 1.62949203673814 0.0643797324273675 no 313 0.0516044496482328 88 739892 SGTC_1074 carmofur 3.8 µM 1.62151787694809 0.0653288061462162 no 314 0.052453309588249 102 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1179 1021-1431 9.29 µM 1.62086305404236 0.0654072219866898 no 315 0.0525235059904708 95 2840958 SGTC_1978 st071761 42 µM 1.61242486428168 0.0664242491320988 no 316 0.0534347589122935 98 5147680 SGTC_3253 9135987 49.47 µM 1.5957049179187 0.0684755670080266 no 317 0.0552773450630894 90 4182430 SGTC_2543 pimpinellin 60.67 µM 1.59296868116764 0.0688158716400148 no 318 0.0555836085621451 82 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1210 3013-0140 750 nM 1.59281881981398 0.0688345474300937 no 319 0.0556004209632619 79 905973 SGTC_611 3453-1652 23.7 µM 1.59045223188777 0.0691299910484627 no 320 0.0558664524051095 113 1560575 SGTC_735 3076-0345 636 µM 1.58950416793001 0.0692486206267409 no 321 0.0559733069110834 77 2888990 SGTC_490 phenamil 164 µM 1.5874977809975 0.0695001933992284 no 322 0.0561999745699587 82 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2101 5377231 179.231 µM 1.57919883333049 0.0705482466492312 no 323 0.0571452287445123 98 2844213 SGTC_1311 1190-0148 100 µM 1.57845625986599 0.0706426133566805 no 324 0.0572304145738782 99 1961333 SGTC_730 1436-0052 41.2 µM 1.57251665553184 0.0714009167001994 no 325 0.057915389789492 81 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1353 1498-1206 8.11 µM 1.57103643106654 0.0715908644780708 no 326 0.0580870934129343 84 6756808 SGTC_2172 5754775 163.918 µM 1.56975450121701 0.071755679441985 no 327 0.0582361181814194 117 2263357 SGTC_1072 oxiconazole 14.9 nM 1.56783893812329 0.072002501437013 no 328 0.0584593625553034 105 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1490 4089-0339 670 nM 1.56767457476155 0.0720237100868479 no 329 0.0584785491231348 89 742542 SGTC_1398 3558-0053 112 µM 1.56511844111413 0.0723541579013546 no 330 0.0587775701677792 59 4532369 SGTC_2792 7535235 81.82 µM 1.56015550282797 0.072999064587296 no 331 0.0593615690297576 105 1281891 SGTC_873 0591-4978 488 µM 1.55716126670826 0.0733902715983245 no 332 0.0597161009719167 95 3305145 SGTC_1357 1503-1303 39.5 µM 1.55127850847636 0.074163541062078 no 333 0.0604174774464987 87 292895 SGTC_2045 5106652 78.05 µM 1.550727894106 0.0742362348410544 no 334 0.0604834534248346 69 673349 SGTC_2608 thymoquinone 42.66 µM 1.54514921052871 0.0749758211987529 no 335 0.0611550880672589 82 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.54186954890502 0.0754132334333833 no 336 0.0615526485245217 95 66535 A nucleotide analog. SGTC_1871 st057448 67.3 µM 1.54096798116874 0.0755338167116778 no 337 0.0616622894580535 91 691747 SGTC_1271 0832-2808 169 µM 1.53867471778757 0.0758411992185706 no 338 0.0619418637366267 107 3663794 SGTC_1215 3852-0577 11.2 µM 1.53768835494081 0.0759737011138589 no 339 0.0620624161456971 85 2884876 SGTC_633 0437-0093 97.7 µM 1.53321264079718 0.0765771562685785 no 340 0.0626117353424406 91 2831118 SGTC_2194 5927483 104.545 µM 1.53283655824503 0.076628028599634 no 341 0.0626580652607537 63 760979 SGTC_840 0245-0196 390 µM 1.53113122526387 0.0768590299473985 no 342 0.0628684819870332 99 3827528 SGTC_1235 benzylparaben 21.5 µM 1.5295172437283 0.0770781442586009 no 343 0.0630681337951091 93 7180 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.52752704148132 0.07734898753657 no 344 0.0633150041355558 133 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_589 1227-0070 34.1 µM 1.51423579179781 0.0791763376589503 no 345 0.0649830234617362 95 2841384 SGTC_2187 6125751 200 µM 1.51404653432283 0.0792025917807149 no 346 0.0650070187653228 100 874498 SGTC_3220 9131269 49.47 µM 1.5100558764927 0.0797577186486044 no 347 0.0655145835018503 82 17722206 SGTC_1804 st050076 49.1 µM 1.50792707392439 0.0800550503544062 no 348 0.0657865962675544 104 3895976 SGTC_2424 5537928 59.2 µM 1.50354455169644 0.0806697983140817 no 349 0.0663493386822503 101 5382802 SGTC_2418 pentamidine 31.67 µM 1.50111219691348 0.0810125260583355 no 350 0.0666632723197838 110 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1509 1326-1131 80 µM 1.49957662482928 0.0812294590339532 no 351 0.0668620532167669 77 768313 SGTC_178 4092-0806 87.505 µM 1.49801267579847 0.0814508510766501 no 352 0.0670649785761167 114 2169044 SGTC_2652 actinonin 100 µM 1.49649091376203 0.0816667076836491 no 353 0.0672628869756587 92 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_2271 7849410 118.62 µM 1.49607003115673 0.081726484472456 no 354 0.0673177032867511 91 972430 SGTC_3338 9144300 39.5675 µM 1.49383330611205 0.0820447138453234 no 355 0.067609596935656 75 4901274 SGTC_1466 k213-0079 57.5 µM 1.49189139560637 0.0823217549068354 no 356 0.067863809357694 126 3657981 SGTC_433 pimozide 108 µM 1.49160371691319 0.0823628561906304 no 357 0.067901531614779 80 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_420 mitomycin C 81.9 mM 1.48793273158601 0.0828886953561552 no 358 0.0683843173085745 111 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2256 7954252 200 µM 1.47846264049928 0.084256867114996 no 359 0.0696419948362151 103 2972920 SGTC_3339 9145883 14.936 µM 1.47215617388401 0.08517733804902 no 360 0.0704893545751885 79 2030670 SGTC_895 0964-0006 13.7 µM 1.47188151873583 0.0852175963546211 no 361 0.0705264375525335 130 6738897 SGTC_3291 9121177 71.43 µM 1.46954071849688 0.0855612840579719 no 362 0.0708430930003808 79 17015612 SGTC_2128 5255449 168.493 µM 1.46723046502453 0.0859015034268063 no 363 0.071156686050509 98 736008 SGTC_1301 naphtanilide LB 4.81 µM 1.46542364941059 0.0861682888000205 no 364 0.0714026845286225 120 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_341 1486-1430 230 µM 1.4636467001973 0.0864312682818538 no 365 0.0716452528057753 139 2054753 YPL210C SRP72 SGTC_1414 3917-0015 5.4 µM 1.46192065522132 0.0866872883016711 no 366 0.0718814770387432 87 6618702 SGTC_1499 4480-0877 67.3 µM 1.46111286269443 0.0868073006999634 no 367 0.0719922354253052 86 2861909 SGTC_2544 sphondin 68.51 µM 1.46089509635732 0.0868396751193243 no 368 0.0720221162749397 124 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2246 7293507 91.5585 µM 1.46060707470203 0.0868825079609776 no 369 0.0720616518251739 117 887656 SGTC_2393 9031399 185.94 µM 1.45396809570746 0.0878741967882064 no 370 0.0729775758713496 112 1526623 YDL150W RPC53 SGTC_2124 5246320 200 µM 1.45296273756419 0.0880251039323226 no 371 0.0731170500902516 129 579342 SGTC_3205 9113483 49.47 µM 1.45245851629854 0.0881008617120923 no 372 0.0731870779099 94 17018033 SGTC_1001 4048-4355 44.4 µM 1.4523328149773 0.0881197555375745 no 373 0.0732045436893986 122 21824233 SGTC_1629 st005085 44.9 µM 1.44988701885975 0.0884879779516882 no 374 0.0735450139244194 118 24207091 SGTC_2458 5808907 16.39 µM 1.44174681699693 0.0897217683620396 no 375 0.0746869055132781 112 2731747 SGTC_1343 1487-0095 224 µM 1.44165726034369 0.0897354130093447 no 376 0.0746995431639284 111 4560101 YGL055W OLE1 SGTC_2765 myclobutanil 7.74 µM 1.44111843144555 0.0898175403138703 no 377 0.0747756136300131 118 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1329 1447-1697 50.6 µM 1.43049358465089 0.0914483909829368 no 378 0.0762877028876638 94 2840515 SGTC_1484 3473-2379 286 µM 1.42995995026187 0.0915308757866156 no 379 0.0763642570209885 76 671917 SGTC_1952 st077036 64.1 µM 1.42916917805842 0.0916532082060453 no 380 0.0764778071055427 119 2937007 SGTC_2814 7977482 42.97 µM 1.42781672116818 0.0918627139235634 no 381 0.076672309335612 124 6456762 SGTC_1673 st016611 27.3 µM 1.42751372023733 0.0919096996381639 no 382 0.0767159366467798 122 5226799 SGTC_163 TUB2.036 7.546 µM 1.42640971203316 0.0920810464292042 no 383 0.076875055958322 141 15992207 YJR013W GPI14 SGTC_203 k066-0004 30.888 µM 1.42156340861449 0.0928360118167264 no 384 0.0775765168315825 138 6795412 SGTC_2658 polymyxin b sulfate 77.05 µM 1.42095784814532 0.0929306678089487 no 385 0.0776645069942183 114 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3294 9122953 26.2835 µM 1.4119911865278 0.0943406193613098 no 386 0.0789762781402924 105 16459826 SGTC_565 1418-0001 44.5 µM 1.40763623902821 0.0950310723806476 no 387 0.0796194054698638 117 2862145 SGTC_1220 1838-0075 193 µM 1.40699351306272 0.0951332874554499 no 388 0.0797146561691624 97 5529645 SGTC_1255 0566-0045 221 µM 1.40609546178984 0.0952762434256126 no 389 0.0798478899006626 115 2788469 SGTC_1809 st050081 57.6 µM 1.40001508184121 0.0962483093047982 no 390 0.0807544010917498 113 5036894 SGTC_2482 5981709 142.65 µM 1.39337514628935 0.0973181362085506 no 391 0.0817531886772471 134 877755 SGTC_1114 scopoletin 1.73284 µM 1.39250630938354 0.0974587662366459 no 392 0.0818845661942694 97 5280460 A coumarin with genotoxic properties. SGTC_1913 st060213 96.1 µM 1.38861573213441 0.0980903238201749 no 393 0.0824748154400175 113 688959 SGTC_1064 honokiol 6.76 µM 1.38655437904661 0.0984261561611807 no 394 0.0827888438226228 127 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_269 exalamide 29 µM 1.38593269150987 0.0985276055583012 no 395 0.0828837286228039 122 3316 A derivative of salicylamide. SGTC_3008 9078912 71.4286 µM 1.38352882991106 0.098920597369678 no 396 0.0832513868479671 106 16648731 SGTC_107 0358-0022 2.6945 µM 1.37614657713204 0.100134640955875 no 397 0.0843881289001929 102 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1676 st018489 23.4 µM 1.36943663815252 0.101247524460365 no 398 0.0854314141038767 105 3696235 SGTC_3305 9127027 53.8275 µM 1.35963050870706 0.102890098035499 no 399 0.0869734393195716 120 41905295 SGTC_3127 9126946 49.47 µM 1.35850852827466 0.10307926243595 no 400 0.087151189161462 117 27243249 SGTC_195 4234-0266 16.654 µM 1.3549849814731 0.103674969729102 no 401 0.0877111710261213 143 2303354 SGTC_2743 auranofin 4.32 µM 1.35018424919281 0.104490618357315 no 402 0.0884784446138047 85 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_485 niflumic acid 177 µM 1.34740379309653 0.104965141190168 no 403 0.0889251098186739 99 4488 A COX2 inhibitor. SGTC_2549 cedrol 20.94 µM 1.34289038334689 0.105738734309343 no 404 0.0896537354029342 135 6708665 A sedative which affects the nervous system. SGTC_2760 etidronate 98.04 µM 1.33834058122589 0.106522728219124 no 405 0.0903927193808008 115 3305 A chelator and antioxidant. SGTC_2887 9044784 58.44 µM 1.33771591547864 0.10663069355623 no 406 0.0904945304044148 137 6465546 SGTC_1744 st037937 38.9 µM 1.33767905188479 0.106637067415402 no 407 0.0905005412692372 114 1016152 SGTC_1611 st001856 99.4 µM 1.33621379621115 0.106890638578027 no 408 0.0907397014869486 129 647478 SGTC_3105 9121040 49.47 µM 1.3358408253359 0.106955252795922 no 409 0.0908006529169743 86 41448907 SGTC_1992 st073643 23.3 µM 1.33163220814011 0.107686315514621 no 410 0.0914905379115882 125 3161292 SGTC_1896 st058441 89 µM 1.33116561822975 0.107767586206358 no 411 0.0915672608458648 115 688759 SGTC_2390 9097792 176.6 µM 1.32863291815542 0.108209503105176 no 412 0.091984553121113 113 4497149 SGTC_707 0865-0008 204 µM 1.32723798109613 0.108453454310742 no 413 0.0922149860465039 136 723043 SGTC_3126 9127922 49.47 µM 1.32622614786486 0.108630654489057 no 414 0.0923824003431986 171 45595682 SGTC_3060 1327-0027 12.5 µM 1.32442321074831 0.108946914916107 no 415 0.0926812651027682 117 16000455 YPR107C YTH1 SGTC_2112 5488546 200 µM 1.32151508837842 0.109458434192666 no 416 0.0931648374635341 129 600757 SGTC_3306 9127676 59.7925 µM 1.31882700069626 0.109932782810415 no 417 0.0936134776580607 113 41905287 SGTC_1381 2324-0066 62.1 µM 1.31352427226567 0.110872840683493 no 418 0.0945031737521181 137 10885928 SGTC_3001 9076041 71.4286 µM 1.31333314086906 0.110906831302396 no 419 0.0945353579349728 101 16004211 SGTC_315 k915-0449 187 µM 1.310577216058 0.111397772274765 no 420 0.0950003204780129 113 20970215 YNL149C PGA2 SGTC_518 1021-0119 62.6 µM 1.30992894194292 0.111513481583654 no 421 0.0951099375948488 136 1097762 SGTC_2943 9068529 45.32 µM 1.3092169371588 0.111640665143184 no 422 0.0952304382838247 159 3270634 SGTC_2288 7946289 167.31 µM 1.30886683863852 0.11170324037532 no 423 0.0952897306603334 120 1246052 SGTC_2173 5763948 167 µM 1.3084462315825 0.111778451199327 no 424 0.0953610002374388 129 2867177 SGTC_2362 9071156 126 µM 1.30476997925582 0.112437362161744 no 425 0.095985592225363 117 653133 SGTC_1552 6-methylflavone 10.6 µM 1.30392270241328 0.112589616012194 no 426 0.0961299694213258 115 689013 SGTC_631 k072-0230 41.5 µM 1.30310193750883 0.112737246082547 no 427 0.0962699811251754 133 5773147 SGTC_2986 9022445 71.43 µM 1.30180477564138 0.112970846902429 no 428 0.0964915654288447 136 6459286 SGTC_231 b-estradiol 524 µM 1.29863176938071 0.113543716823481 no 429 0.0970351649183027 106 450 A steroid. SGTC_2817 7995342 71.43 µM 1.2976881078289 0.113714488977242 no 430 0.0971972658952196 113 18879975 SGTC_1019 4262-0212 3.4 µM 1.28641334006327 0.115769028819015 no 431 0.0991494225994889 143 4677213 SGTC_137 0438-0332 85.389 µM 1.28548310112037 0.115939711023001 no 432 0.0993117591347043 162 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_3177 9107506 49.47 µM 1.28061487393727 0.116835857726426 no 433 0.100164486497149 104 8897194 SGTC_694 1315-0438 43.2 µM 1.28019499059365 0.116913379527301 no 434 0.100238283638488 112 6793154 SGTC_3263 9137018 49.47 µM 1.27764713836203 0.117384563636897 no 435 0.10068693590038 145 43844957 SGTC_1971 st069429 63.5 µM 1.27744254182051 0.117422458707967 no 436 0.10072302680949 101 1246522 YGL099W LSG1 SGTC_3012 9080433 71.4286 µM 1.27509409070846 0.117858055857743 no 437 0.101137970361754 150 17688859 SGTC_2113 5491891 107.031 µM 1.27237805198952 0.118363258482262 no 438 0.101619414213259 133 789979 SGTC_2037 5169046 200 µM 1.26937316982308 0.118923969620242 no 439 0.102154000377465 133 5718022 SGTC_1889 st059080 5.18 µM 1.26701806631788 0.119364741369858 no 440 0.102574415033818 107 176925 Isolated from Daphnopsis sellowiana. SGTC_2739 tacrine 100.86 µM 1.26373208551112 0.119981656790343 no 441 0.103163102340126 120 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3251 9135047 49.47 µM 1.26324432892074 0.120073420223988 no 442 0.103250693207522 106 17682963 SGTC_1106 tegaserod maleate 11.7 µM 1.26219408388684 0.120271174549429 no 443 0.103439478505265 148 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_396 dithiazanine 1.25 µM 1.25457495275047 0.121712678912262 no 444 0.104816550386008 108 10578 An antihelmenthic. SGTC_3138 9097216 49.47 µM 1.25302035998844 0.122008285762588 no 445 0.105099148598152 140 25237486 SGTC_1361 1608-0041 5.61 µM 1.25216565366763 0.122171023385341 no 446 0.105254754227473 129 X1361 SGTC_1277 0873-0036 22 µM 1.25207952561133 0.12218743077082 no 447 0.105270443719533 135 5965735 SGTC_3243 9134147 49.47 µM 1.25028919764531 0.122528838407201 no 448 0.10559696152847 125 24282180 SGTC_57 miconazole 162.5 nM 1.24703690999755 0.123150746449444 no 449 0.106191982065858 152 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_623 k072-0108 16.9 µM 1.24591162153148 0.123366440318841 no 450 0.106398421514907 151 5382803 SGTC_2331 7980721 200 µM 1.24502444759785 0.123536679181217 no 451 0.106561381915056 152 2981221 SGTC_1876 myriocin 605 nM 1.24476358457678 0.123586767196096 no 452 0.106609332756944 148 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_3017 9080681 49.47 µM 1.24454121043698 0.12362947623213 no 453 0.10665022101572 129 16451914 SGTC_1419 3993-2473 62.6 µM 1.24302844431039 0.1239202914423 no 454 0.106928675968388 136 704026 SGTC_1962 st076595 64.5 µM 1.23866029017035 0.124762714496877 no 455 0.107735665203901 159 279619 SGTC_474 dl-dihydrosphingosine 5 µM 1.23788647431736 0.124912365524495 no 456 0.107879079113887 140 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2601 securinine 100 µM 1.23645213834148 0.125190088475895 no 457 0.108145272977137 166 442872 A GABA receptor antagonist. SGTC_790 1575-0012 79.1 µM 1.23285357219794 0.125888756917137 no 458 0.108815199919277 143 378741 YLR208W SEC13 SGTC_2025 5147754 141 µM 1.23187163055207 0.126079874090405 no 459 0.108998520161295 119 315777 YLR208W SEC13 SGTC_2788 5282734 71.43 µM 1.23025824761849 0.126394328915486 no 460 0.109300207004126 149 743706 SGTC_1408 3909-7976 48.8 µM 1.230051883972 0.126434589403898 no 461 0.109338838218473 132 24152374 SGTC_290 2043-6722 48.1 µM 1.22954232645157 0.126534039727194 no 462 0.109434269245309 133 773758 YLR208W SEC13 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.22694830258106 0.127041159993779 no 463 0.109921011095166 121 4174840 SGTC_1907 st060210 83.7 µM 1.2236668280464 0.127684697884024 no 464 0.110538969117764 146 688793 SGTC_452 diindolylmethane 8 µM 1.21989501890327 0.128427191520351 no 465 0.111252337170733 125 3071 Inhibits expression of several cancer promoting factors. SGTC_1694 st024011 44.9 µM 1.2188523898707 0.128632964362422 no 466 0.111450111393623 135 2787533 SGTC_1891 st059073 26.2 µM 1.21798089770782 0.128805137153179 no 467 0.111615615961589 152 688754 SGTC_1392 3455-1037 33.9 µM 1.21698940952584 0.129001210788256 no 468 0.111804122645649 125 981132 SGTC_1417 3966-0327 90.4 µM 1.21216196528725 0.129958827930798 no 469 0.11272519384648 136 651118 SGTC_2200 6600604 21.907 µM 1.21195987091451 0.129999024303037 no 470 0.11276387105166 160 2904777 SGTC_3135 9127742 49.47 µM 1.20895179329281 0.130598345468934 no 471 0.113340683098428 131 3643468 SGTC_2873 9040596 71.43 µM 1.20852347308523 0.130683837947534 no 472 0.113422986233634 159 6463863 SGTC_2481 5478948 45.16 µM 1.20779539336232 0.130829251026866 no 473 0.113562986933353 131 77792 SGTC_232 clozapine 119 µM 1.20529354569003 0.131329775642842 no 474 0.114045000188502 131 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2539 epi(13)torulosol 80 µM 1.20398717051673 0.131591656470006 no 475 0.114297268649092 147 6708597 SGTC_692 k241-0027 77.8 µM 1.20298190262109 0.13179342143829 no 476 0.114491661928132 141 3600480 SGTC_1208 2323-2347 50.3 µM 1.20144811030905 0.132101676381189 no 477 0.114788711677931 124 5412760 SGTC_2903 5923464 63.88 µM 1.19875930544608 0.132643259636051 no 478 0.115310775178767 142 2876576 SGTC_2296 7971656 126.45 µM 1.19779843071605 0.132837170955352 no 479 0.115497749148415 120 666570 SGTC_534 k292-0788 63.4 µM 1.19738884529168 0.132919887501537 no 480 0.115577514697619 180 4146317 SGTC_2138 5575593 77.673 µM 1.1959603615655 0.133208649954737 no 481 0.115856013923467 123 762213 SGTC_884 0851-0618 334 µM 1.19516980353268 0.133368643625269 no 482 0.11601034692437 146 9642473 SGTC_463 ikarugamyin 104 µM 1.19355235730545 0.133696395271701 no 483 0.116326559944094 96 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2272 7805186 180 µM 1.19180294217121 0.134051511370794 no 484 0.116669260939894 152 2956062 YPR165W RHO1 SGTC_638 3970-0837 4.09 µM 1.19132069344478 0.134149517522738 no 485 0.116763856609477 120 4118451 YLR208W SEC13 SGTC_1200 1643-0193 18.4 µM 1.18761107539278 0.134905059070868 no 486 0.117493336177161 157 5403974 SGTC_1117 retinoic acid 1.10837 µM 1.18645156354574 0.135141815632013 no 487 0.117722009440491 129 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1472 k841-0093 193 µM 1.18596853661802 0.135240527179545 no 488 0.117817362529912 138 X1472 SGTC_897 1000-0139 31.4 µM 1.1859276777949 0.13524887936944 no 489 0.117825430870199 143 6151020 SGTC_2233 sulbentine 40.3845 µM 1.18589966085228 0.135254606680146 no 490 0.117830963566489 175 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_159 3970-0959 50 µM 1.18482057677485 0.135475322939537 no 491 0.118044197547385 167 6615653 SGTC_3066 9117245 49.47 µM 1.18354229787789 0.135737101783596 no 492 0.118297146701409 128 17176980 SGTC_3308 9128332 17.569 µM 1.18093171253917 0.136272799507157 no 493 0.118814926034894 148 17332805 YDL196W YDL196W SGTC_1960 st011366 51.8 µM 1.18050776043866 0.136359931741874 no 494 0.118899162878666 155 3972846 SGTC_2302 7771753 200 µM 1.17752541089494 0.136973952545325 no 495 0.119492930636634 138 2203047 SGTC_1514 1189-1591 158 µM 1.17621184519696 0.137244994368968 no 496 0.119755116128112 153 767698 YMR146C TIF34 SGTC_1364 1653-0028 37.6 µM 1.17223873558802 0.138067036474815 no 497 0.120550610317613 136 5718652 SGTC_620 0109-0052 432 µM 1.166363310371 0.139288813634552 no 498 0.121733792991247 157 493037 SGTC_1637 st007924 17.4 µM 1.16579247410128 0.139407908213183 no 499 0.12184918038076 126 683336 SGTC_2694 st077685 81.9 µM 1.16417976852508 0.139744744034908 no 500 0.122175583671101 139 2838096 SGTC_1573 oleylamine 1.06 µM 1.16089315666913 0.14043290988228 no 501 0.122842676088847 164 5356789 An amine of the fatty acid oleic acid. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.16076147270727 0.140460530332616 no 502 0.122869457452601 154 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1988 st071872 53.4 µM 1.16071636906629 0.140469991579953 no 503 0.122878631394106 121 16414116 SGTC_1299 1079-1439 3.74 µM 1.16062331129548 0.140489513379835 no 504 0.122897560575487 157 323161 SGTC_96 0929-0093 37.281 µM 1.16031655929721 0.140553877320057 no 505 0.122959972467273 168 6991579 SGTC_1124 fisetin 1.16336 µM 1.15943445493228 0.140739075540083 no 506 0.123139569612143 143 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_871 0574-0004 149 µM 1.15807482721891 0.141024854191247 no 507 0.123416750837429 166 9551173 SGTC_3151 9099821 49.47 µM 1.1534200464462 0.142006216055269 no 508 0.124369008635689 151 17174189 SGTC_2129 girgensonine 121.053 µM 1.15328112931024 0.142035574660009 no 509 0.124397506532514 181 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_55 0767-0285 6.563 µM 1.15213484165699 0.142277986741683 no 510 0.124632833878614 155 3116166 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.15074192811834 0.142572930779222 no 511 0.124919210905774 134 2724278 An inhibitor of dopamine biosynthesis. SGTC_3199 9111318 49.47 µM 1.15069345027296 0.142583203214976 no 512 0.124929186013517 142 8548020 SGTC_3122 9126309 49.47 µM 1.14931277064489 0.142875978792095 no 513 0.12521351701464 180 17591206 SGTC_956 1185-0240 191 µM 1.14744072654968 0.143273597604275 no 514 0.125599758640316 145 1416193 SGTC_2974 9094440 9.66 µM 1.14581438268861 0.143619636204892 no 515 0.125935981385158 149 25236134 SGTC_3073 9114972 49.47 µM 1.14508168439464 0.143775717213737 no 516 0.126087660907252 124 41905075 SGTC_1390 3413-2614 145 µM 1.14368133552547 0.144074340911375 no 517 0.126377908303191 174 3421432 SGTC_2091 4-phenylthiadiazole 200 µM 1.14299344322409 0.144221186686338 no 518 0.126520656692742 140 270010 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.1417449198344 0.144487969205394 no 519 0.126780031632033 161 688803 SGTC_717 1532-0246 73.2 µM 1.14167741086811 0.144502403885314 no 520 0.126794066849402 145 9561992 SGTC_2736 butenafine 14.65 µM 1.14019893731139 0.144818772848529 no 521 0.127101715070103 148 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_663 1486-0733 13.9 µM 1.13968051961416 0.144929816052316 no 522 0.12720971293533 156 722445 YPR165W RHO1 SGTC_645 0845-0943 5.41 µM 1.1381228773973 0.145263802198445 no 523 0.127534588267326 144 1885106 SGTC_1671 st016596 74.5 µM 1.13730526702987 0.14543931946339 no 524 0.127705346842806 163 2829167 SGTC_2776 terbinafine 19.92 µM 1.13351948260071 0.146253876477652 no 525 0.128498082166618 145 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3280 9140961 49.47 µM 1.13315572658453 0.146332303971556 no 526 0.128574431382615 162 4901226 SGTC_1774 st048371 48.465 µM 1.13062736947153 0.146878209757948 no 527 0.12910598140656 193 4242727 SGTC_2350 9023895 38.85 µM 1.12990589638686 0.147034235548734 no 528 0.129257939565816 147 2997209 SGTC_2854 9024559 71.43 µM 1.12803548020662 0.147439249203447 no 529 0.129652467655366 138 3163529 SGTC_489 paxilline 115 µM 1.1262655509536 0.147823191492806 no 530 0.130026567308606 146 105008 A toxic potassium channel blocker. SGTC_1821 st053465 65.6 µM 1.12457157461947 0.148191284095969 no 531 0.130385312345538 137 675086 SGTC_1468 k284-1086 134 µM 1.12442889731173 0.148222315140836 no 532 0.130415559332282 167 15996457 SGTC_469 w7 172 µM 1.11993619718878 0.149201661262191 no 533 0.131370475939005 135 45115570 A P450 inhibitor. SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.11852828444552 0.149509453905294 no 534 0.131670716686926 171 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2899 9053889 58.44 µM 1.11641246905796 0.149972802005147 no 535 0.132122809290924 150 6470052 SGTC_3013 9080133 71.4286 µM 1.11616857504014 0.15002627449513 no 536 0.132174991571274 158 17050193 SGTC_3237 9133362 49.47 µM 1.11337419487809 0.150639834866142 no 537 0.132773876527344 161 43845137 SGTC_114 0364-0001 490.298 µM 1.11304346856508 0.150712562680282 no 538 0.132844880490943 171 4003655 SGTC_2184 6075246 200 µM 1.110111948038 0.151358235758365 no 539 0.133475394622866 157 2267320 SGTC_2119 5528445 120.635 µM 1.10868562441842 0.151673050598742 no 540 0.133782912791453 149 791935 SGTC_2683 piperine 63.03 µM 1.10635946075869 0.152187409056829 no 541 0.134285482381671 179 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3313 9133968 57.047 µM 1.10382685979692 0.152748730106882 no 542 0.13483412550483 155 1494643 SGTC_927 2425-1185 123 µM 1.10373570457747 0.152768959152244 no 543 0.13485390129892 172 730375 SGTC_2469 5655019 90.81 µM 1.1032722582489 0.152871834026268 no 544 0.134954475073396 150 2788239 SGTC_1837 st055472 66.5 µM 1.09845482720925 0.153943917683769 no 545 0.13600296630497 151 676091 SGTC_2493 resveratrol 26.09 µM 1.09335447670308 0.155084372229381 no 546 0.137119096417714 124 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_1784 st039334 36.3 µM 1.0917867282823 0.155436043786466 no 547 0.137463426923247 183 3496984 SGTC_2298 7976326 193.81 µM 1.08942885159753 0.15596594402969 no 548 0.137982407064075 116 2235818 SGTC_824 1304-0008 100 µM 1.08846970354429 0.156181839619916 no 549 0.138193902127041 160 768245 SGTC_2869 9037858 32.47 µM 1.0872270383586 0.156461845034444 no 550 0.138468242105592 161 27187042 SGTC_2249 haloperidol 116.36 µM 1.08631915546469 0.156666623970878 no 551 0.138668907534774 201 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1002 4049-0206 172 µM 1.08148748378625 0.15775940567417 no 552 0.139740162627265 168 4662749 SGTC_2491 paeonol 100 µM 1.08012336626422 0.158068832968243 no 553 0.140043623988253 157 11092 Increases levels of cortical cytochrome oxidase. SGTC_174 3553-0389 74.3 µM 1.078216790722 0.158501974895879 no 554 0.140468510229139 158 738071 SGTC_3163 9099914 49.47 µM 1.07821504432396 0.15850237200469 no 555 0.1404688998201 185 16268368 SGTC_2682 pyrogallin 40.03 µM 1.07724257437005 0.158723600713205 no 556 0.140685954859506 156 822798 An ATP competetive kinase inhibitor. SGTC_1097 itavastatin 7.23 µM 1.07559579551617 0.159098690431764 no 557 0.14105403430632 177 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1967 st070177 51.4 µM 1.07313669753999 0.159659883619821 no 558 0.141604893910678 166 5729214 SGTC_581 0958-0271 211 µM 1.07264226943987 0.15977287376381 no 559 0.141715825898121 147 4591145 SGTC_34 0469-0683 81.75 µM 1.07176941184208 0.15997247291351 no 560 0.141911807583616 145 3690923 SGTC_2759 disulfiram 3.38 µM 1.06901165880293 0.160604168203634 no 561 0.142532207982848 180 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_3198 9112019 49.47 µM 1.06850813292407 0.160719682302186 no 562 0.142645681867535 188 45595555 SGTC_1771 st048882 4.1505 µM 1.06749935977122 0.160951268593288 no 563 0.142873201297911 182 4580403 SGTC_1418 3966-3099 2.4 µM 1.06610205327182 0.161272410973086 no 564 0.143188755775519 182 740335 SGTC_875 0709-0210 25.7 µM 1.06505517345918 0.161513288628906 no 565 0.143425481453651 176 6251364 SGTC_1260 0700-1617 7.75 µM 1.06336622290935 0.161902395237727 no 566 0.143807952102804 171 2853078 SGTC_3354 9151612 71.43 µM 1.06278664600917 0.162036060912874 no 567 0.143939358405516 150 27261949 SGTC_1127 asiatic acid 681.4 nM 1.06250288262935 0.162101530413437 no 568 0.144003725029711 168 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_139 0099-0334 718.624 µM 1.05691889263908 0.163393365239724 no 569 0.145274302650739 174 97690 SGTC_2479 5617353 43.85 µM 1.05594069067071 0.163620355017334 no 570 0.145497656142089 177 2731746 SGTC_1627 st003713 25.6 µM 1.04916425347611 0.165198432205571 no 571 0.147051263875466 166 16195070 YER133W GLC7 SGTC_508 roscovitine 141 µM 1.04869871897133 0.165307204978464 no 572 0.147158402018098 189 160355 A CDKinase inhibitor. SGTC_2176 5809774 33.9695 µM 1.04867697498379 0.165312286623477 no 573 0.147163407459749 146 2870539 SGTC_1749 st037932 54.2 µM 1.04789317460771 0.165495530971995 no 574 0.147343913643446 176 594497 SGTC_3094 9117742 49.47 µM 1.04767016713604 0.165547691792093 no 575 0.147395298500962 207 17149698 SGTC_1877 wortmannin 25 µM 1.04620105708259 0.165891578216256 no 576 0.147734107484477 173 312145 A covalent inhibitor of PI 3-kinase. SGTC_1540 guanosine 70.6 µM 1.04594721032019 0.16595104492086 no 577 0.147792702914511 157 6802 Guanosine is a purine nucleoside SGTC_760 0568-0725 82.9 µM 1.04292812162429 0.166659359392653 no 578 0.148490792046418 186 3916171 SGTC_1797 st048695 56.8 µM 1.04153647727067 0.16698651183413 no 579 0.14881331641856 189 592262 YIL048W NEO1 SGTC_1885 st057546 99.9 µM 1.03275638225423 0.169060107421743 no 580 0.150858960268477 170 702008 SGTC_2399 5884133 200 µM 1.03262086796826 0.169092240883915 no 581 0.150890679261005 176 722445 SGTC_643 k048-0106 28.4 µM 1.03105608763721 0.169463569324947 no 582 0.151257259298503 190 6763920 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.03048753232595 0.169598619211639 no 583 0.151390600971946 173 364106 SGTC_1623 st003709 20.3 µM 1.03017586690077 0.16967267890669 no 584 0.151463728144749 182 16192618 SGTC_778 3456-2434 196 µM 1.02899355608087 0.169953814840773 no 585 0.15174135147162 173 5539063 SGTC_716 1683-5115 658 µM 1.02854048801586 0.170061626787534 no 586 0.151847827837357 182 723597 SGTC_2508 celastrol 40.54 µM 1.02779782640015 0.170238445124837 no 587 0.152022469471856 145 122724 Celastrol is a natural product and antioxidant. SGTC_710 3448-4187 58 µM 1.02685507876599 0.170463071010942 no 588 0.15224435470389 178 3946412 SGTC_1565 sinapyl alcohol 95.1 µM 1.02668048864972 0.170504690938772 no 589 0.152285469845391 188 5280507 A phenol propionate derived from cinnamic acid. SGTC_1425 4048-4433 7.33 µM 1.0255972907042 0.170763056118677 no 590 0.152540722527411 219 23734946 SGTC_920 mycophenolic acid 780.421 nM 1.0255946009197 0.170763697999788 no 591 0.15254135672103 154 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2866 9034245 58.44 µM 1.02460249169881 0.17100055692359 no 592 0.152775394173768 160 6462273 SGTC_2204 7233102 200 µM 1.02259426151712 0.171480650331938 no 593 0.153249861977678 159 2172480 SGTC_3082 9117008 49.47 µM 1.02207725451862 0.171604386837207 no 594 0.153372168781992 174 41448529 SGTC_3097 9117246 49.47 µM 1.02058590752843 0.171961633947643 no 595 0.153725334492769 169 16423892 SGTC_2900 5328528 85.29 µM 1.01997203649561 0.17210882252068 no 596 0.153870861507684 190 795359 SGTC_3169 9102970 49.47 µM 1.01720659960216 0.172772891217859 no 597 0.154527578579539 184 17027839 SGTC_975 1335-0046 28.5 µM 1.01514629213237 0.173268696240349 no 598 0.155018048864386 183 16486740 SGTC_407 eburnamonine 100 µM 1.01497010221034 0.173311137672687 no 599 0.155060039742657 169 3195 SGTC_1670 st016595 4.04 µM 1.01433925695387 0.173463152826885 no 600 0.155210449006598 206 597879 SGTC_597 k018-0003 82.8 µM 1.01218651057387 0.173982540093493 no 601 0.155724442356865 201 6786234 SGTC_598 3937-0236 20.2 µM 1.00921330419248 0.174701501563004 no 602 0.156436173735112 207 1379313 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.00691546849282 0.175258439556447 no 603 0.156987698932016 170 4330530 SGTC_2921 7974240 10.71 µM 1.00671261063563 0.175307661263606 no 604 0.157036450128217 179 2979074 YDR527W RBA50 SGTC_1379 2144-0755 36.5 µM 1.00666146518938 0.175320072647906 no 605 0.157048743073354 195 5392327 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.00478363170719 0.175776149233661 no 606 0.15750052361494 183 688662 SGTC_3020 9089140 49.47 µM 1.00334732574298 0.176125497142582 no 607 0.157846654685032 191 17217859 SGTC_2069 5228469 200 µM 1.00024649036426 0.176881200436077 no 608 0.158595617830199 192 2835210 SGTC_1661 st013063 9.66 µM 1.00012855510275 0.176909982784645 no 609 0.158624149359558 193 721395 SGTC_3114 9122766 49.47 µM 1.00005412257896 0.176928149722034 no 610 0.158642158206211 149 17176985 SGTC_503 tyrphostin 8 294 µM 0.995272192152993 0.178097758018472 no 611 0.159801949296527 204 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_287 k060-0039 29.6 µM 0.99521019374255 0.178112954094364 no 612 0.159817022486955 185 5861974 SGTC_1209 2323-2347 50.3 µM 0.994170986782201 0.178367789835027 no 613 0.160069815227148 176 5412760 SGTC_1182 1222-0449 220 µM 0.993768821077335 0.178466471077614 no 614 0.16016771434968 180 658318 SGTC_2053 5265679 138 µM 0.992691330939573 0.178731029236385 no 615 0.160430200453617 212 764595 SGTC_1717 st033143 58.0435 µM 0.992489034878012 0.178780726881234 no 616 0.160479512880054 172 674616 SGTC_2178 5812956 200 µM 0.991741701571393 0.178964398091741 no 617 0.16066177143194 196 5403383 SGTC_1847 st056231 15 µM 0.991575195846666 0.179005336173417 no 618 0.160702397011998 185 5393180 SGTC_952 1185-0122 232 µM 0.991320291380533 0.179068019906504 no 619 0.16076460391566 169 678600 SGTC_759 3486-0358 89.3 µM 0.988958868443228 0.179649375451283 no 620 0.161341633145913 201 875103 SGTC_726 3448-4391 34.2 µM 0.98837485995976 0.17979333444084 no 621 0.161484547551897 191 1356692 SGTC_1675 st018485 24.5 µM 0.987651458062397 0.179971754567547 no 622 0.16166168773383 202 3323024 SGTC_3331 9141060 1.957 µM 0.987643258521744 0.17997377754251 no 623 0.161663696289617 171 4906567 YPR165W RHO1 SGTC_2774 tamoxifen 10.92 µM 0.985137041299108 0.180592775750204 no 624 0.162278380408805 184 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2181 6316240 54.2555 µM 0.982444718826094 0.181259224809849 no 625 0.16294040233876 173 12779990 SGTC_2939 9044578 71.43 µM 0.981308179362113 0.181541021965606 no 626 0.163220395212256 178 2653634 SGTC_3006 9075424 71.4286 µM 0.980568622590543 0.18172453717085 no 627 0.163402756978739 207 7465181 SGTC_2807 7945238 51.95 µM 0.978401126200509 0.182263052621991 no 628 0.163937985710975 193 17148797 SGTC_149 3970-0822 46.1 µM 0.976884453109956 0.182640463163081 no 629 0.164313179704874 193 3114250 YBL034C STU1 SGTC_2413 inermin 26.06 µM 0.974462254984814 0.183244216682222 no 630 0.16491353577608 224 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2157 5649910 96.377 µM 0.969899349562211 0.184384935875773 no 631 0.166048332160388 179 2858091 SGTC_245 methotrexate 289.6 µM 0.968537916534832 0.184726145893047 no 632 0.166387896079444 175 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2829 7992743 58.44 µM 0.965407061104135 0.185512306636559 no 633 0.167170483072862 184 16462845 SGTC_3125 9127534 49.47 µM 0.963844125042781 0.185905537221143 no 634 0.167562040274731 174 1639235 SGTC_313 3474-0040 5.03 µM 0.961930882221074 0.186387607124101 no 635 0.168042162245388 211 1043375 YIL048W NEO1 SGTC_1397 3532-0190 20.1 µM 0.953961403057388 0.188403954508577 no 636 0.170051590003058 158 5322280 SGTC_2988 9073640 71.4286 µM 0.953811451103175 0.188442022157065 no 637 0.170089545970881 196 9102229 SGTC_743 1275-0778 158 µM 0.950938956282933 0.189172165445079 no 638 0.17081768235904 222 2849257 YMR203W TOM40 SGTC_3282 9108498 15.4605 µM 0.95034738696101 0.189322749161828 no 639 0.17096788406826 199 16459645 SGTC_288 1315-0019 35.1 µM 0.950165322981356 0.189369108314555 no 640 0.171014127806179 216 6811474 SGTC_167 3672-0051 66.205 µM 0.950078235872751 0.189391285871684 no 641 0.171036250515123 184 3237971 SGTC_275 trichlorophene 5.69 µM 0.949839704556646 0.18945203831592 no 642 0.171096853918337 189 62616 SGTC_2786 7743617 45.45 µM 0.949833599700789 0.18945359334216 no 643 0.171098405152938 176 583674 SGTC_2226 7298446 200 µM 0.949642340740514 0.189502314719406 no 644 0.171147008319449 177 3283010 SGTC_100 0086-0128 49.5915 µM 0.949156625896614 0.18962608054341 no 645 0.171270478970821 206 93297 SGTC_2018 5133068 143 µM 0.948608400111455 0.189765834608241 no 646 0.171409908551055 203 785362 SGTC_763 3453-1109 128 µM 0.948497597246702 0.189794088237736 no 647 0.171438097716505 199 1560353 SGTC_2284 7945075 39.21 µM 0.947957842367533 0.18993175735794 no 648 0.171575458190908 212 1245402 SGTC_1689 st020265 53.493 µM 0.947211115920275 0.190122317538819 no 649 0.17176560609428 189 5758320 YPR016C TIF6 SGTC_2349 9023730 187.07 µM 0.945886754661074 0.190460575553486 no 650 0.17210317497125 182 4126287 SGTC_246 cycloheximide 667 µM 0.943169704430779 0.191155699187728 no 651 0.172797053380313 200 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1799 st045822 46.1415 µM 0.941898297904709 0.191481506343537 no 652 0.173122355827094 200 3674992 SGTC_1021 4476-0760 85.3 µM 0.940792598253816 0.191765126338053 no 653 0.173405577366599 172 746768 SGTC_1706 st031321 9.9705 µM 0.939429648645509 0.192115086566187 no 654 0.173755098300096 191 6103185 SGTC_708 3448-5400 146 µM 0.937394081874401 0.192638479606014 no 655 0.174277942018828 224 3462195 SGTC_1052 3253-3998 198 µM 0.936175028581267 0.19295234425202 no 656 0.174591538997789 186 5450317 SGTC_3025 9087895 49.47 µM 0.935818379806695 0.193044228165773 no 657 0.174683353294564 202 17173641 SGTC_2957 9076800 11.52 µM 0.931218101919785 0.194231797529934 no 658 0.175870377980476 183 16459615 SGTC_3045 9092950 49.47 µM 0.931126095650754 0.194255594393653 no 659 0.175894170647961 200 44120432 SGTC_3252 9135871 49.47 µM 0.930527250871554 0.194410525347856 no 660 0.176049080716922 202 17682838 SGTC_3325 9138760 55.175 µM 0.929068518578796 0.19478823796075 no 661 0.176426789108275 180 43844959 SGTC_664 1222-0054 14.9 µM 0.928144791683264 0.195027651165049 no 662 0.176666233872873 195 6813991 SGTC_429 1112-0049 25.5 µM 0.927821064409656 0.195111597699596 no 663 0.176750197754187 186 2836170 SGTC_1775 st081588 35.1725 µM 0.927468736070408 0.195202985803531 no 664 0.176841608446778 198 1426443 YGL099W LSG1 SGTC_1761 st044296 37 µM 0.927262535983379 0.195256482737245 no 665 0.176895120394386 210 1826700 SGTC_1462 k081-0014 26.5 µM 0.926482328005349 0.195458981957319 no 666 0.177097688414768 174 3270634 SGTC_2670 beta-carotene 100 µM 0.926431472176104 0.195472185769246 no 667 0.177110897369983 162 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1328 1441-0025 69.2 µM 0.926238716167937 0.195522236357499 no 668 0.17716096818461 186 4562601 SGTC_1354 1498-1681 81 µM 0.924598176859161 0.195948529988813 no 669 0.177587480871792 188 5754243 SGTC_2011 4012611 177 µM 0.924049477802374 0.196091235015645 no 670 0.177730277911756 175 2049887 SGTC_1762 st045503 25.4615 µM 0.922123372353429 0.196592673118571 no 671 0.178232113479099 200 4645554 SGTC_2318 6029776 164 µM 0.920681051103863 0.196968672073012 no 672 0.178608486041178 203 818325 SGTC_641 4092-0595 30 µM 0.91948307352962 0.19728130373312 no 673 0.178921477535691 203 786260 SGTC_2068 5226020 147 µM 0.919040698047411 0.197396824627622 no 674 0.179037142675063 204 1810509 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.918758578564226 0.197470518005735 no 675 0.179110931247462 217 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_142 0335-0849 62.6745 µM 0.916648149731445 0.198022317702918 no 676 0.179663522260512 209 3889043 YPR107C YTH1 SGTC_1443 4112-3303 14 µM 0.916336182427933 0.198103964630572 no 677 0.179745298023751 218 704433 SGTC_2703 st077852 53.4 µM 0.91504482557531 0.198442149919342 no 678 0.180084049142352 215 6281836 SGTC_2624 nerol 100 µM 0.911484983640185 0.199376216382892 no 679 0.181019947060565 218 637566 A natural product oil. SGTC_1650 st011916 45.8 µM 0.911359156340494 0.199409280556078 no 680 0.181053083272523 215 242528 SGTC_1947 st076332 61.6 µM 0.910310739452761 0.199684905831972 no 681 0.18132932819908 222 24208416 SGTC_329 k048-0121 21.3 µM 0.909122883476148 0.19999746599294 no 682 0.181642632328694 200 6832902 SGTC_1150 3909-7983 10.9 µM 0.908772971822553 0.200089594191101 no 683 0.181734988174265 225 23965914 SGTC_233 rapamycin 362 pM 0.908032227428105 0.20028470884137 no 684 0.181930597501227 224 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3236 9132701 49.47 µM 0.90723043730191 0.200496031939559 no 685 0.182142475584408 212 24282524 SGTC_2107 5363541 170.161 µM 0.906542745548165 0.200677389439371 no 686 0.182324325284755 205 244052 SGTC_3003 9075612 71.4286 µM 0.904049324443941 0.201335777785887 no 687 0.182984623747098 231 6501993 SGTC_3183 9108214 49.47 µM 0.902523904487484 0.201739202837536 no 688 0.183389314469678 166 4974831 SGTC_2292 7671323 168.05 µM 0.896621616560305 0.20330472479955 no 689 0.184960429651583 236 937504 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.895147697544829 0.203696795178196 no 690 0.185354069703841 185 688664 SGTC_944 3370-0224 231 µM 0.894329935960276 0.203914518461644 no 691 0.185572693738721 181 4580514 SGTC_2001 4023502 57.655 µM 0.894123773920693 0.20396942953844 no 692 0.185627835265364 185 108941 YCR052W RSC6 SGTC_2084 5306078 60.6385 µM 0.893506862899367 0.204133795863629 no 693 0.18579289927793 221 679340 SGTC_2029 5175081 200 µM 0.893424576227124 0.204155725826559 no 694 0.185814923219705 199 1380876 SGTC_867 0518-0118 155 µM 0.893317521721932 0.204184258687142 no 695 0.185843578669655 226 6848158 SGTC_247 mechlorethamine 29.705 µM 0.89254121023083 0.204391237302114 no 696 0.186051457191832 190 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1851 st056236 18.9 µM 0.891000424548123 0.20480240825098 no 697 0.186464471237 206 5393171 SGTC_2561 acetosyringone 100 µM 0.88844463227863 0.205485525527043 no 698 0.187150813110715 246 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1928 4'-methoxychalcone 40.3 µM 0.886340640572307 0.206048898674788 no 699 0.187716997733675 220 641818 SGTC_1457 k015-0032 57.3 µM 0.885447074489224 0.206288440311248 no 700 0.187957776321358 212 4302660 SGTC_2339 9000433 200 µM 0.879216402057734 0.207963302796082 no 701 0.189641976402416 217 2988954 SGTC_322 k048-0136 19.3 µM 0.877845764977166 0.208332817166787 no 702 0.190013712411603 215 6823282 SGTC_889 0919-1524 82.7 µM 0.877577225168732 0.208405259007872 no 703 0.190086596612829 194 3905452 SGTC_721 1187-1332 279 µM 0.877239398097515 0.208496413018748 no 704 0.190178310419736 212 25730 SGTC_3024 9090631 49.47 µM 0.876542970206019 0.208684400477919 no 705 0.190367463501902 197 25236383 SGTC_3153 9100258 49.47 µM 0.87493018783888 0.209120123765763 no 706 0.190805946179979 206 25236848 SGTC_359 0081-0058 15.9 µM 0.874201949699527 0.209317046327022 no 707 0.191004142224856 216 3494159 SGTC_3309 9129340 25.759 µM 0.871751235854514 0.209980543933349 no 708 0.191672051245687 215 17158987 SGTC_2490 carminic acid 95.39 µM 0.871447623657874 0.210062828779031 no 709 0.191754896122163 208 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_732 3970-1727 52.7 µM 0.870483294981097 0.210324306329482 no 710 0.192018172205812 239 1275699 SGTC_1287 0971-0001 34.6 µM 0.867656426927857 0.211091911483429 no 711 0.192791223077028 207 4665869 SGTC_1190 1486-1332 13 µM 0.866162247178935 0.211498302103883 no 712 0.193200596689364 228 4150046 SGTC_1037 k284-1091 78.7 µM 0.865688728748082 0.211627186323759 no 713 0.193330441351027 200 3334711 SGTC_2924 9010168 62.78 µM 0.863493911547337 0.21222518093859 no 714 0.193932982754752 215 2993929 SGTC_2442 5158906 48.48 µM 0.862768797218243 0.212422960700645 no 715 0.194132299039075 213 1893835 SGTC_1862 st057513 3.81 µM 0.862244325129177 0.212566081047308 no 716 0.194276541392079 225 5393163 SGTC_899 1083-0020 478 µM 0.859537585852522 0.213305603304052 no 717 0.195021996369281 237 767123 SGTC_957 1187-1561 14.1 µM 0.85914493914641 0.213413004791477 no 718 0.195130278268374 226 1538454 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.857920049297937 0.213748253995181 no 719 0.195468306233075 211 279621 SGTC_1025 k007-0731 70 µM 0.856527088528492 0.214129876279663 no 720 0.195853147952952 220 6256118 SGTC_2175 5807670 165.306 µM 0.854783297545513 0.214608172103931 no 721 0.196335563211909 192 241186 SGTC_2360 9040895 200 µM 0.85322546405161 0.215035987268334 no 722 0.19676714241527 212 4914414 SGTC_482 fipronil 114 µM 0.85126073396031 0.215576250621138 no 723 0.197312265945323 213 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_653 0203-0016 55.2 µM 0.850135186870386 0.215886108939548 no 724 0.197624965375085 223 295302 SGTC_2073 5212005 126 µM 0.848797522816021 0.216254697564202 no 725 0.197996984413222 232 691789 SGTC_2865 9030313 51.95 µM 0.847991938909975 0.216476849043934 no 726 0.198221230043127 211 42562754 SGTC_1269 0831-0796 3.05 µM 0.847472930865375 0.216620042979446 no 727 0.198365784414072 220 927758 SGTC_3346 9158254 43.5805 µM 0.84608833635809 0.217002319527276 no 728 0.198751733448155 239 17639500 SGTC_1192 1488-0095 21.4 µM 0.841269199802649 0.218335884458844 no 729 0.200098570649826 223 915875 SGTC_1395 3486-0190 4.35 µM 0.839240114185803 0.218898788027325 no 730 0.200667290528093 221 6748079 SGTC_1372 2752-0194 270 µM 0.839218361841766 0.218904827024676 no 731 0.200673392610758 212 823334 SGTC_2524 avocatin b 10.57 µM 0.838273735649113 0.219167171434138 no 732 0.200938491593105 201 6710748 SGTC_3351 9150312 21.596 µM 0.837636047157905 0.219344374338045 no 733 0.201117570614287 235 4904905 SGTC_2790 5423970 71.43 µM 0.836543006613098 0.219648303349638 no 734 0.201424746529239 224 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_7 0192-1582 4.227 µM 0.835916435221972 0.219822635724092 no 735 0.201600957876085 256 252616 SGTC_2664 lyso-paf C-16 73.48 µM 0.833560875252272 0.220478738592393 no 736 0.202264240276409 246 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_701 4424-0219 185 µM 0.833423599054403 0.220517009216621 no 737 0.202302934942021 223 2911779 SGTC_2837 9008476 45.46 µM 0.830688653211193 0.221280265657674 no 738 0.203074769007366 211 2992805 SGTC_1336 1486-0901 104 µM 0.83039536070484 0.221362206027712 no 739 0.203157643877314 216 5006114 SGTC_2231 micatex 6.853 µM 0.828347927830737 0.221934703109613 no 740 0.203736743649585 238 20737 An antifungal of unknown mechanism. SGTC_1153 4055-0057 267 µM 0.827972082973582 0.222039887501389 no 741 0.203843155123854 250 882706 SGTC_419 nsc-638432 893 µM 0.827941366679394 0.222048485058069 no 742 0.203851853171281 224 368090 SGTC_805 3852-0218 479 µM 0.824948176543158 0.222887196512596 no 743 0.204700506607815 227 6615355 SGTC_2438 5259590 200 µM 0.82377534282102 0.223216323682833 no 744 0.205033610149374 230 1201127 SGTC_158 k038-0087 26.446 µM 0.823549374531899 0.223279767941256 no 745 0.205097825757692 224 X158 SGTC_20 0481-0013 4.944 µM 0.822937517839006 0.223451608130043 no 746 0.205271763019361 240 182045 SGTC_424 splitomicin 100 mM 0.822885903301784 0.223466107533143 no 747 0.205286439892323 233 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1613 st002381 52.1 µM 0.821803762480544 0.223770222551322 no 748 0.205594296014753 229 551167 SGTC_249 wiskostatin 11.211 µM 0.821482644303358 0.223860511929453 no 749 0.20568570299969 215 2775510 A n-wasp and actin depolymerizer. SGTC_1562 morin hydrate 59.1 µM 0.821000826489637 0.22399602434671 no 750 0.205822898721469 223 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1055 3448-0672 86 µM 0.81887868908067 0.224593434972035 no 751 0.206427814883724 214 748378 SGTC_254 nsc-64875 3.808 µM 0.818150384269948 0.224798670858237 no 752 0.206635661023371 213 56993 SGTC_820 1582-0060 59.9 µM 0.818122087335203 0.224806647064062 no 753 0.206643739000634 228 3848840 SGTC_2628 lathosterol 100 µM 0.817413394288565 0.225006462428392 no 754 0.206846111876365 218 6710616 SGTC_1897 st060201 15 µM 0.817021253028575 0.225117069542913 no 755 0.20695814129684 224 611878 SGTC_198 3454-2873 16.191 µM 0.813444576569276 0.22612732533528 no 756 0.207981605285737 245 710957 SGTC_2874 9043904 71.43 µM 0.812975049220287 0.226260136410708 no 757 0.208116181799392 227 4463428 SGTC_1234 0326-0494 15.5 µM 0.811856436319082 0.226576726104526 no 758 0.208437007021422 248 1547813 SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.811822159868664 0.226586430968534 no 759 0.208446842326642 233 165506 SGTC_1232 0279-0259 161 µM 0.811796860567331 0.226593594237627 no 760 0.208454101898878 231 1560000 SGTC_2815 7968870 71.43 µM 0.810765597735321 0.226885695795583 no 761 0.208750147119786 218 2977326 YHR190W ERG9 SGTC_1274 0865-0114 173 µM 0.810336464601047 0.22700730879415 no 762 0.208873411586643 224 870624 SGTC_2055 5235184 200 µM 0.808863067219076 0.227425137813745 no 763 0.209296957406927 248 2836034 SGTC_2611 pyromycin 23.93 µM 0.808172222109968 0.227621198154515 no 764 0.209495723100739 228 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_659 k018-0002 107 µM 0.806076382361046 0.228216574814509 no 765 0.210099404256188 235 6797879 YHR007C ERG11 SGTC_1864 st057645 30.4 µM 0.80477468470584 0.228586795478257 no 766 0.210474856347658 251 688666 SGTC_554 4483-2211 187 µM 0.804723166787391 0.228601454816766 no 767 0.210489723893831 226 747107 SGTC_1303 1160-0052 261 µM 0.804360181885629 0.228704756534814 no 768 0.210594495107188 228 3562476 SGTC_1024 4507-0395 26 µM 0.799755663637814 0.23001742717561 no 769 0.211926187681165 230 4201836 SGTC_1332 1480-0653 17.5 µM 0.799094420647514 0.230206282031527 no 770 0.212117832286643 228 5749438 SGTC_686 1319-0111 510 µM 0.798275294160053 0.230440349555718 no 771 0.212355375894636 278 4562600 SGTC_2906 7926292 26.41 µM 0.79692546776387 0.23082635605846 no 772 0.212747159446258 245 2966319 SGTC_328 k915-0120 63.5 µM 0.796629686929255 0.230910987975922 no 773 0.21283306538551 213 6624543 SGTC_1719 st032227 49.2 µM 0.79612766844784 0.231054670423841 no 774 0.212978916873491 242 3125804 SGTC_2199 6590217 200 µM 0.796046240773255 0.231077980498625 no 775 0.213002579561096 215 703109 SGTC_2946 9065502 71.43 µM 0.793711288071033 0.231746959086454 no 776 0.213681763625206 194 16489101 SGTC_1497 4476-2978 41.3 µM 0.793377503479164 0.231842678537593 no 777 0.213778956845739 225 1528379 SGTC_2329 6138490 200 µM 0.792849221886293 0.231994218918127 no 778 0.21393283737554 237 720019 SGTC_1186 1319-0216 26 µM 0.792377854085756 0.232129479821778 no 779 0.21407019419138 245 4565136 SGTC_869 0564-0080 44.1 µM 0.792356188112381 0.23213569801577 no 780 0.214076508900553 210 6843321 SGTC_1154 4088-0362 150 µM 0.790598333008183 0.232640516074299 no 781 0.214589209960276 243 6618304 SGTC_345 1362-0200 395 µM 0.789602589345302 0.232926742694222 no 782 0.21487994779217 247 1419823 SGTC_1115 galangin 695.678 nM 0.789247751196652 0.233028788211078 no 783 0.21498360891881 256 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_575 k072-0246 11.9 µM 0.785999557190758 0.233964067386944 no 784 0.215933873279173 236 6796779 SGTC_864 0469-0573 172 µM 0.785478954169798 0.23411416201134 no 785 0.216086402496832 241 689425 SGTC_650 1328-0195 38 µM 0.784821261954709 0.234303856916162 no 786 0.216279186070061 256 2780821 SGTC_546 peri-Naphthalide 147 µM 0.784603780902154 0.234366602609864 no 787 0.21634295629116 235 223824 A penicillin ester. SGTC_2502 avocadyne acetate 18.59 µM 0.784265478710294 0.234464225021319 no 788 0.216442175553826 231 3952079 SGTC_1757 st041620 31.8375 µM 0.783737194748718 0.234616714642692 no 789 0.21659716644669 241 5289815 SGTC_1739 st037196 92.5 µM 0.78324005800498 0.234760263671656 no 790 0.216743077815663 232 612214 SGTC_2009 4012297 12.05 µM 0.781723565062149 0.235198453257164 no 791 0.21718852478809 222 45595307 SGTC_2553 4-methylesculetin 85.09 µM 0.780002789458552 0.23569621670724 no 792 0.217694616634944 233 5319502 SGTC_3081 9117243 49.47 µM 0.778758714223695 0.236056448051529 no 793 0.218060931046633 258 45595589 SGTC_1051 3253-3903 78 µM 0.776358179162742 0.236752397634057 no 794 0.218768765141107 262 5509239 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.774721614587676 0.237227507353276 no 795 0.219252088016267 251 165521 SGTC_3179 9107801 49.47 µM 0.774549709675727 0.237277443303981 no 796 0.219302891897212 225 4818259 SGTC_2278 7948257 134.34 µM 0.774171006812674 0.237387471505564 no 797 0.219414835632021 243 1247028 SGTC_464 bw-b 70c 158 µM 0.768847997020655 0.238936977376437 no 798 0.220991775894691 257 5353454 SGTC_3155 9099265 49.47 µM 0.766470209775582 0.23963092422571 no 799 0.221698285449209 245 25236499 SGTC_547 1120-0019 610 nM 0.765703692883877 0.239854863084437 no 800 0.221926314624758 235 3676939 SGTC_791 1348-1292 225 µM 0.765571501722583 0.239893494433738 no 801 0.221965653375926 248 5437054 SGTC_4 0960-0234 25.671 µM 0.765440008001778 0.239931925330702 no 802 0.222004788525767 241 6821112 SGTC_1683 st010134 710 nM 0.764092662314043 0.240325899533739 no 803 0.222406012351491 241 3818134 SGTC_2382 9035899 200 µM 0.763437342169312 0.24051764748822 no 804 0.222601308449229 262 6462679 SGTC_1144 3486-0183 12.5 µM 0.7633375137799 0.240546864780127 no 805 0.222631067517159 260 6744069 SGTC_2563 tomatine 8.54 µM 0.76311201471902 0.240612869870817 no 806 0.222698297642434 249 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2007 4011539 71.82 µM 0.760876365163565 0.241267792655711 no 807 0.223365458311703 236 45595301 SGTC_1830 st055982 50.3 µM 0.759333356861023 0.241720373945038 no 808 0.223826584142767 264 455313 An antimicrobial agent. SGTC_2063 5246145 200 µM 0.759132994346783 0.241779176256514 no 809 0.223886501860843 242 711240 SGTC_577 r071-0003 38.6 µM 0.7587195584409 0.241900535794709 no 810 0.224010167246562 276 4568517 YMR134W ERG29 SGTC_2878 9043973 25.97 µM 0.758484756055059 0.241969474149829 no 811 0.224080417723574 250 6465167 SGTC_284 0988-0104 32.6 µM 0.75705471977492 0.242389565083101 no 812 0.224508540080898 263 4666532 SGTC_2638 epoxomicin 18 µM 0.755231867802906 0.242925622884544 no 813 0.225054935343656 245 9915668 A protesome inhibitor. SGTC_1091 telmisartan 47.6 µM 0.754191624800155 0.243231821045167 no 814 0.225367082945483 258 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_929 2805-0021 398 µM 0.753920082175088 0.243311784629611 no 815 0.225448605561251 267 3098024 SGTC_538 2922-0838 53.3 µM 0.751066649454344 0.244152918911739 no 816 0.226306272806953 236 777039 SGTC_1759 st043059 70 µM 0.748661547575107 0.244863110316967 no 817 0.227030612753235 273 669426 SGTC_383 2324-0395 7.37 µM 0.746015878093078 0.245645620191947 no 818 0.22782891173149 241 3146421 SGTC_2080 5212524 12.4 µM 0.746013351011484 0.245646368268533 no 819 0.227829675002349 273 260183 SGTC_2062 5245942 200 µM 0.743157230882622 0.246492629691101 no 820 0.228693246826524 248 1376160 SGTC_1162 k048-0130 20.1 µM 0.742825300563324 0.246591081054098 no 821 0.228793727812922 250 6797406 SGTC_3231 9132313 49.47 µM 0.742757750209181 0.246611119237242 no 822 0.228814179495335 249 4905967 SGTC_769 0302-0231 76 µM 0.742394221628718 0.24671897157835 no 823 0.228924259766391 274 571869 YER009W NTF2 SGTC_2697 mebhydrolin 72.4 µM 0.742347851825361 0.246732730474648 no 824 0.228938303166556 264 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.742124964481719 0.246798871572475 no 825 0.229005812811884 252 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1641 st009299 47.1 µM 0.741814880552359 0.246890903760993 no 826 0.229099751731782 250 4046054 SGTC_1147 3809-1045 12.3 µM 0.741237367640126 0.247062357199097 no 827 0.229274764995753 243 325925 SGTC_378 3970-0959 8.33 µM 0.740942362035211 0.247149963753414 no 828 0.229364194327784 263 6615653 SGTC_2127 5253358 187.912 µM 0.739695159328654 0.247520523742342 no 829 0.229742492988606 241 20612 SGTC_3256 9138902 49.47 µM 0.738711848487573 0.247812887205672 no 830 0.230040994747529 282 17228773 SGTC_2236 dapsone 200 µM 0.738404713642289 0.247904244021361 no 831 0.230134275536844 244 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_896 0964-0007 44.5 µM 0.73814226917145 0.247982321989782 no 832 0.230214000050406 245 6756758 SGTC_1238 0333-0287 48.8 µM 0.738027603215311 0.248016439552914 no 833 0.230248837744083 254 7226 SGTC_1169 aniline yellow 25.8 µM 0.737083772975395 0.248297360728409 no 834 0.230535703275044 266 6051 A DNA damaging agent. SGTC_2260 7964312 200 µM 0.736570989325378 0.248450056496367 no 835 0.230691641227636 257 231951 SGTC_2952 9073731 13.78 µM 0.736085284271901 0.248594734985964 no 836 0.230839398880887 268 16457353 SGTC_3168 9103419 49.47 µM 0.734334997364965 0.249116470498733 no 837 0.231372296559347 254 16649256 SGTC_857 0438-0306 1.35 µM 0.733678744980457 0.249312239985707 no 838 0.231572277859409 252 4686136 SGTC_2456 5770359 74.46 µM 0.731710617499882 0.249899850743145 no 839 0.232172607254452 280 3118787 SGTC_925 2064-1272 59.6 µM 0.731478479219002 0.249969207162345 no 840 0.232243472449184 251 6815817 SGTC_2420 aureobasidin a 50 nM 0.731274518455795 0.250030153357473 no 841 0.232305745783439 247 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_2989 9073649 71.4286 µM 0.730882935421241 0.250147185684236 no 842 0.232425330015951 274 21367202 SGTC_555 4296-0685 37 µM 0.73083296884718 0.250162121272189 no 843 0.232440591603545 273 2908540 YHR072W ERG7 SGTC_1742 st038235 28.8875 µM 0.730630993204633 0.250222498951841 no 844 0.23250228790349 273 564103 YBR002C RER2 SGTC_2299 7976368 114.88 µM 0.730422947019977 0.250284699410479 no 845 0.232565848055648 254 2979718 SGTC_367 0335-0881 7.1 µM 0.730187939342225 0.250354970521422 no 846 0.232637656826869 267 23828853 SGTC_989 1501-0895 10.3 µM 0.729022092206625 0.250703732325685 no 847 0.232994074384265 259 2830112 SGTC_1620 st003704 16.5 µM 0.727954909057079 0.251023204332048 no 848 0.233320594508277 259 2834414 SGTC_116 0155-0182 31.788 µM 0.727885380341764 0.25104402592369 no 849 0.233341876631508 226 771486 SGTC_819 1013-0258 27.7 µM 0.727598740757549 0.251129874815746 no 850 0.233429625839299 251 5753198 SGTC_3296 9122258 64.045 µM 0.726186910361952 0.251552946185082 no 851 0.233862097643699 249 4730474 SGTC_845 0330-0138 4.51 µM 0.725411923567888 0.251785339958256 no 852 0.234099680171219 263 9039800 SGTC_1295 1013-0063 9.78 µM 0.725342806111678 0.251806071578815 no 853 0.234120875538372 264 6826038 SGTC_480 am 92016 50 µM 0.721959084001176 0.252822112223878 no 854 0.235159816838632 305 2129 K+ channel blocker. SGTC_2198 6589944 200 µM 0.721762988466999 0.252881060525556 no 855 0.235220104155513 251 5290268 SGTC_3298 9116858 71.43 µM 0.721025468158718 0.253102831347764 no 856 0.23544692268407 283 2506942 SGTC_753 1322-0200 289 µM 0.720837666209839 0.253159319341017 no 857 0.235504698960437 251 5403907 SGTC_1048 3161-0300 24.5 µM 0.719867981370731 0.253451091384485 no 858 0.235803141812205 238 2165101 SGTC_1935 st074532 41.6 µM 0.71945168714686 0.253576405882812 no 859 0.235931329897786 270 2829742 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.719173552064317 0.253660149316036 no 860 0.236016996500267 268 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_350 k064-0020 19.8 µM 0.719118073934099 0.25367685491203 no 861 0.236034086013421 254 2790705 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.718641750944531 0.253820309247811 no 862 0.236180840858144 281 688801 SGTC_294 k038-0071 157 µM 0.718112614001491 0.253979719494547 no 863 0.236343926560325 269 24152826 SGTC_2583 asiatic acid 100 µM 0.717330486293357 0.254215443089434 no 864 0.236585100250376 291 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_423 5-fluorouracil 457 µM 0.717180957329792 0.254260522324622 no 865 0.236631223801567 262 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1923 st058458 19.1 µM 0.716667007129756 0.254415497383566 no 866 0.236789794071259 290 3534982 SGTC_1684 st024538 14.6195 µM 0.716169948709914 0.254565426019959 no 867 0.236943208249025 259 6732859 SGTC_1487 3970-0795 2.82 µM 0.714841601490889 0.254966324816453 no 868 0.237353462843774 261 3765103 SGTC_1421 4029-0249 71.4 µM 0.713860570453255 0.255262614588223 no 869 0.237656700489668 271 2894095 SGTC_772 k072-0172 35.3 µM 0.711189842627115 0.256070135621538 no 870 0.238483301020125 243 5861980 SGTC_876 0720-0963 56.8 µM 0.709527154691385 0.256573537955533 no 871 0.238998703248407 266 765861 SGTC_1722 st034304 3.6505 µM 0.708624427235457 0.256847067220364 no 872 0.239278786783539 273 4036148 YLR033W RSC58 SGTC_1242 0402-0103 60.1 µM 0.708372180617905 0.256923525859324 no 873 0.239357081787311 267 432868 SGTC_843 0310-0051 143 µM 0.705632857783673 0.25775460579983 no 874 0.240208242580919 275 2065037 SGTC_1914 st062367 72.6 µM 0.705287790885925 0.257859394113649 no 875 0.240315578423475 272 978205 SGTC_98 0074-0023 107.663 µM 0.703868423682333 0.258290653316913 no 876 0.240757358719151 265 3563821 SGTC_1288 0973-0013 65.5 µM 0.703295917288451 0.258464708858885 no 877 0.240935677246096 257 4315430 SGTC_387 norethindrone acetate 66.7 µM 0.701270444142061 0.25908098816381 no 878 0.241567127492298 269 541197 SGTC_445 e6 berbamine 66 µM 0.700497206625844 0.259316457024874 no 879 0.241808424519506 274 6610268 A calcium/calmodulin antagonist. SGTC_656 4090-1979 187 µM 0.699939572704057 0.259486338165818 no 880 0.241982521282972 251 22330961 SGTC_54 0159-0055 9 µM 0.695155566972121 0.260946126229246 no 881 0.243478907310243 293 3319099 SGTC_3145 9085516 49.47 µM 0.692968399871128 0.261614920793087 no 882 0.244164691351379 278 25236195 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.690848152529898 0.26226409130083 no 883 0.244830485721352 260 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1049 3226-0134 66 µM 0.689243596094519 0.262755917171962 no 884 0.245334993061678 266 5702385 SGTC_2959 9079155 11 µM 0.688265897119465 0.263055830920028 no 885 0.245642676581471 282 16189457 SGTC_3262 9137218 49.47 µM 0.685874555175085 0.26379012280967 no 886 0.246396108427062 239 17650664 SGTC_2973 9094665 17.96 µM 0.683519934119203 0.26451415896101 no 887 0.247139179181865 285 25237061 YIL048W NEO1 SGTC_2274 7947094 46.08 µM 0.682550710605415 0.264812484659075 no 888 0.247445394365649 269 2971028 SGTC_2723 salbutamol 83.58 µM 0.681261943571636 0.265209430184994 no 889 0.247852879545208 277 9884233 β2-adrenoceptor agonist SGTC_212 3807-4682 38.772 µM 0.678952368043232 0.265921543986639 no 890 0.248584021408496 273 3125501 YBL034C STU1 SGTC_2738 aclarubicin 5.55 µM 0.675441112943218 0.267006025837116 no 891 0.249697776228946 239 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1309 pyrazolanthrone 13.4 µM 0.675119305031044 0.267105530645216 no 892 0.249799984704524 290 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1944 st076371 56.9 µM 0.674011105965431 0.267448335183536 no 893 0.250152126472325 282 24208455 SGTC_399 oxolinic acid 75 µM 0.673482441594276 0.267611947610323 no 894 0.250320207786337 266 4628 A DNA gyrase inhibitor. SGTC_3022 9087993 49.47 µM 0.673403640818321 0.267636339399828 no 895 0.250345266498193 279 17173644 SGTC_1567 st069303 68.4 µM 0.672956144556713 0.267774877489628 no 896 0.250487595894277 279 5581319 SGTC_1866 st057638 64 µM 0.672744116125953 0.267840530905375 no 897 0.250555048026216 270 688802 SGTC_446 go6976 132 µM 0.672634475308689 0.267874483750557 no 898 0.250589931589344 289 3501 A protein kinase C inhibitor. SGTC_973 1325-0077 65.9 µM 0.672584320562077 0.267890016064341 no 899 0.250605889791262 278 2835149 SGTC_3189 9110682 49.47 µM 0.671214607871522 0.268314374663916 no 900 0.251041912035443 280 17122418 SGTC_2733 amorolfine 100 µM 0.670086752482987 0.268664055720523 no 901 0.251401244660749 303 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2938 9059746 27.26 µM 0.668249830450756 0.269234066041337 no 902 0.251987066039873 283 6471769 SGTC_134 0269-0018 6.916 µM 0.667904670405682 0.269341239384421 no 903 0.252097222978744 283 4378915 SGTC_1347 1493-0251 600 nM 0.666314927191857 0.269835135946089 no 904 0.252604913193433 270 3986378 SGTC_1587 estradiol valerate 56.1 µM 0.665876501549984 0.269971424409678 no 905 0.252745020686495 298 13791 A steroid. SGTC_2395 5646831 180.19 µM 0.6645853092835 0.270373002894766 no 906 0.253157884032724 300 6808628 SGTC_827 3253-0474 693 µM 0.664494210896804 0.270401347012966 no 907 0.253187026457693 285 5402065 SGTC_196 k015-0023 18.111 µM 0.663987664230652 0.270558979724651 no 908 0.25334910319388 271 5211998 SGTC_141 0443-0274 32.331 µM 0.662352019253316 0.27106829077857 no 909 0.253872822974749 251 1627241 SGTC_3106 9121286 49.47 µM 0.66220743963648 0.27111333331796 no 910 0.25391914347271 259 15943471 SGTC_1616 st002734 56.1 µM 0.661861786585524 0.271221033687251 no 911 0.254029901964201 277 4026101 SGTC_202 3594-0513 34.79 µM 0.661734228585857 0.271260784257229 no 912 0.25407078210236 282 708429 SGTC_1752 st044819 83.042 µM 0.657662437948523 0.272531189668643 no 913 0.255377531913261 277 441209 YML126C ERG13 SGTC_2149 5554786 194.827 µM 0.656815519392076 0.272795800289713 no 914 0.25564977202673 286 745063 YPR165W RHO1 SGTC_1125 tnp00248 1.32998 µM 0.656413489533036 0.272921454803868 no 915 0.255779056671396 296 24207736 SGTC_2724 maprotiline 69.64 µM 0.656073367335273 0.273027782473346 no 916 0.255888459714247 293 4011 A tricyclic antidepressant. SGTC_1825 st052143 62.6 µM 0.654944064398003 0.273380967950702 no 917 0.256251884169684 284 674173 SGTC_3345 9148410 3.559 µM 0.654078132181815 0.273651938329338 no 918 0.256530734641055 284 4903596 SGTC_2291 7917025 104.35 µM 0.651844839657005 0.274351400329468 no 919 0.257250636028398 283 2964612 SGTC_207 4185-0010 4.486 µM 0.650481260366907 0.274778903697479 no 920 0.257690701324355 290 3761753 SGTC_144 4161-2749 112.381 µM 0.649725811889416 0.275015889864312 no 921 0.257934673877545 280 797501 YMR168C CEP3 SGTC_1104 tacrolimus 29.8 µM 0.649369624084177 0.275127661830261 no 922 0.25804974650583 287 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2714 st079313 56.9 µM 0.649284857899387 0.275154264809379 no 923 0.258077135608806 287 2939799 SGTC_728 3030-5151 22.5 µM 0.648868036385059 0.275285098300109 no 924 0.258211838217842 294 3125388 SGTC_1776 st049249 45.9 µM 0.647310517618026 0.2757742489048 no 925 0.258715497923447 284 1822314 SGTC_1401 3807-4679 7.6 µM 0.646787314113787 0.275938660731946 no 926 0.258884801905276 301 3291456 SGTC_2337 9009472 200 µM 0.646047753990443 0.276171142706338 no 927 0.259124214696228 292 5742383 SGTC_1217 1183-1422 255 µM 0.645918964050057 0.276211637868086 no 928 0.259165918691094 283 2849664 SGTC_1158 4092-0494 91.8 µM 0.645325303093764 0.276398339153497 no 929 0.259358199310483 278 1148199 SGTC_1998 st075797 76.8 µM 0.644914831960934 0.276527464991694 no 930 0.259491189733253 284 24208315 SGTC_230 MPP+ 141.667 µM 0.644104148463863 0.276782576321745 no 931 0.259753950221111 295 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_426 0988-0037 14.6 µM 0.643866832399769 0.276857278344241 no 932 0.259830895589295 292 5383008 SGTC_1659 st012954 42.1 µM 0.642979268734812 0.277136751898005 no 933 0.260118775981923 284 24207262 SGTC_2354 9060492 162 µM 0.641917111856834 0.277471382210707 no 934 0.260463501503535 301 6471895 SGTC_1252 0493-0875 34.8 µM 0.640311450960468 0.277977616965139 no 935 0.260985068829576 274 3960963 SGTC_2748 diazoxide 86.69 µM 0.639648048070037 0.278186906947028 no 936 0.261200718867634 244 3019 A potassium channel activatior. SGTC_2104 5389443 200 µM 0.638997089892074 0.278392345543406 no 937 0.261412412517152 296 2244536 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.636565198598535 0.279160489624884 no 938 0.262204049926369 299 688751 SGTC_140 0062-0056 502.533 µM 0.636102580530527 0.279306730037976 no 939 0.262354781840911 278 3758964 SGTC_1505 k297-0037 20.6 µM 0.634948593946032 0.279671684418993 no 940 0.262730971289632 284 4089396 SGTC_2749 bexarotene 57.39 µM 0.634542550491525 0.279800152836218 no 941 0.262863403471131 292 82146 An retinoic acid receptor inhibitor. SGTC_499 genistein 192 µM 0.633367623726897 0.280172050053033 no 942 0.263246801236761 307 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_905 2-aminofluorene 215 µM 0.633205644462702 0.280223339804882 no 943 0.263299680106113 289 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2450 5739737 12.93 µM 0.632636218488444 0.280403681180267 no 944 0.263485614854426 294 2262825 SGTC_3246 9135460 32.98 µM 0.631017643732125 0.280916602310343 no 945 0.264014494041905 297 41446951 SGTC_813 k007-0158 173 µM 0.630210813590596 0.281172453450733 no 946 0.264278332618146 294 6523916 SGTC_2082 5219693 150 µM 0.629938166360402 0.281258937112247 no 947 0.264367520332261 290 2834649 SGTC_1625 st003711 30.1 µM 0.628875940339713 0.281595997485362 no 948 0.26471513925274 295 24207034 YER133W GLC7 SGTC_3117 9124945 49.47 µM 0.626988008869411 0.282195547047525 no 949 0.265333547691323 279 17592065 SGTC_1407 3909-7909 12.3 µM 0.625169997893849 0.282773472069168 no 950 0.265929745338998 270 4411780 SGTC_2191 5911152 200 µM 0.622557118167954 0.28360507132629 no 951 0.26678779901662 292 2875902 SGTC_2784 7567673 72.73 µM 0.622050130824996 0.28376656543003 no 952 0.266954452481918 295 3471247 SGTC_1018 4259-0013 28.1 µM 0.622042110704845 0.283769120486842 no 953 0.266957089224228 296 6801262 SGTC_1196 1588-0294 184 µM 0.621851373744134 0.283829888878717 no 954 0.267019800915919 318 6144269 SGTC_1570 verbenone 133 µM 0.621025904747179 0.284092953351419 no 955 0.267291289519888 301 29025 A natural terpanoid with antifungal properties. SGTC_274 sirtinol 40.1 µM 0.620295182991488 0.28432592057917 no 956 0.267531732855225 272 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.620117662711758 0.284382531016833 no 957 0.267590162204338 285 77254 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.619895829112402 0.284453280347122 no 958 0.267663185961692 254 4000243 SGTC_2429 5902844 64.44 µM 0.618361048280985 0.284942997781551 no 959 0.268168684053433 305 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_3077 9117319 49.47 µM 0.618267042842522 0.284973006074807 no 960 0.268199661455518 313 17154678 SGTC_2004 4023728 41.89 µM 0.615483554622796 0.285862229827854 no 961 0.269117713309788 316 360084 YDR527W RBA50 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.614530537189581 0.286166987309415 no 962 0.269432400093424 308 390807 SGTC_2852 9023854 51.95 µM 0.614506593206559 0.286174646142645 no 963 0.269440308782157 322 19798528 SGTC_703 3875-0075 71.8 µM 0.613788115935199 0.286404506887727 no 964 0.269677675680512 323 2850814 SGTC_1498 4478-3555 97.6 µM 0.611830707676264 0.287031180077599 no 965 0.27032488530709 285 3437919 SGTC_2768 sulfasalazine 50.2 µM 0.608469617178064 0.288108760942233 no 966 0.271438025512775 311 5384001 An antioxidant and salicylic acid derivative. SGTC_861 0443-0273 110 µM 0.607015774430141 0.28857546023745 no 967 0.271920221826004 313 6149169 SGTC_69 0096-0274 206.684 µM 0.60683404498825 0.288633822393759 no 968 0.271980526013211 318 6741392 SGTC_691 1548-0686 185 µM 0.603356394991005 0.28975173453504 no 969 0.273135811874478 303 46495133 SGTC_2022 5136654 200 µM 0.603258271580073 0.289783306362957 no 970 0.273168444010781 313 1713771 SGTC_1842 st055362 61.2 µM 0.602899669206703 0.289898702669794 no 971 0.273287718029069 290 676032 SGTC_1119 parthenolide 318.541 nM 0.60238645524158 0.290063889633875 no 972 0.273458461963344 330 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_3098 9119039 49.47 µM 0.602224136842361 0.290116143854812 no 973 0.273512475541638 300 17161528 SGTC_38 0929-0051 58.268 µM 0.601580353562819 0.290323436706398 no 974 0.273726754872099 311 1379719 SGTC_1801 st050089 28.441 µM 0.601526131816681 0.290340898823375 no 975 0.27374480603958 290 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2584 androsterone 48.74 µM 0.599122287434182 0.291115550832353 no 976 0.27454567016003 277 2754130 A steroid. SGTC_1702 st027038 51 µM 0.598515404371806 0.291311274720635 no 977 0.274748041752848 288 5521182 SGTC_2888 9058547 12.99 µM 0.595974838822576 0.292131290198194 no 978 0.275596017824972 287 16476514 SGTC_996 3970-0799 1.8 µM 0.595678360875634 0.292227054001936 no 979 0.275695058401851 318 6615648 YGL040C HEM2 SGTC_2006 4011487 200 µM 0.595612759218644 0.292248245625973 no 980 0.275716975467894 307 45595294 SGTC_3281 9140613 49.47 µM 0.592951763623192 0.293108442005138 no 981 0.276606717161404 276 16013766 SGTC_2520 obtusaquinone 4.71 µM 0.591786285205997 0.293485565269533 no 982 0.276996854114691 313 5967872 SGTC_612 0302-0167 22.4 µM 0.591205314130024 0.293673638671364 no 983 0.277191431273849 329 235821 SGTC_394 menadione 8.33 µM 0.590146951451939 0.294016397771408 no 984 0.277546066822664 308 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1167 k781-0610 148 µM 0.590078712476485 0.294038503847021 no 985 0.277568939905076 299 4525169 SGTC_229 benomyl 22.8748 µM 0.589448230479568 0.294242785373543 no 986 0.277780315280048 301 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_223 busulfan 5 mM 0.588916033233057 0.294415272814514 no 987 0.27795880086682 299 2478 A DNA alkylator. SGTC_2522 biochanin a 4.94 µM 0.588887449814035 0.294424538145584 no 988 0.277968388610967 301 5280373 A possible chelator. SGTC_2085 5307070 144.047 µM 0.587328144768431 0.294930191571261 no 989 0.278491671140328 335 2840351 SGTC_2102 5377816 72.7585 µM 0.586025258666894 0.295352999763776 no 990 0.278929270507539 313 1379702 SGTC_2675 theaflavin digallate 100 µM 0.585480159689529 0.295529976153173 no 991 0.279112451689521 297 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2098 5376439 882.5 nM 0.584484785779214 0.295853268320083 no 992 0.279447099159316 318 2844116 SGTC_670 4204-0025 119 µM 0.583993710849263 0.296012826668546 no 993 0.279612271667769 317 719039 SGTC_226 1,3-diallylurea 8.28947 mM 0.582946722700707 0.296353142213566 no 994 0.279964583116214 304 74537 YKL182W FAS1 SGTC_2721 ifenprodil 61.44 µM 0.5826466430034 0.296450713903588 no 995 0.280065599586391 308 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_3266 9136860 49.47 µM 0.582141005345667 0.296615156593803 no 996 0.280235853426056 303 4871271 YPR165W RHO1 SGTC_1895 st058434 18.3 µM 0.581368894033275 0.296866342010328 no 997 0.280495928612095 336 5393175 SGTC_1205 4161-2785 76 µM 0.581173060532968 0.296930066586484 no 998 0.280561911029343 293 3498106 SGTC_379 3970-0972 5.9 µM 0.580632579699377 0.297105972493895 no 999 0.280744054848734 305 2898042 YBL034C STU1 SGTC_2629 bisabolol 100 µM 0.577053009778929 0.298272186926975 no 1000 0.281951823153618 341 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2754 granisetron 64.02 µM 0.575319158204035 0.298837819492967 no 1001 0.282537733472349 332 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1206 3978-0017 132 µM 0.57378846847027 0.299337579483134 no 1002 0.283055476523206 321 3873677 SGTC_2761 levamisole 97.89 µM 0.572704315429667 0.2996917773845 no 1003 0.283422457522757 325 26879 An alkaline phosphatase inhibitor. SGTC_888 0916-0002 6.97 µM 0.572449706731995 0.299774986764486 no 1004 0.283508674498773 303 2802138 YIL048W NEO1 SGTC_1300 1094-0077 113 µM 0.572299084008203 0.299824217122539 no 1005 0.283559685097754 324 5532636 SGTC_3047 9092122 49.47 µM 0.571916008072333 0.299949440254938 no 1006 0.283689439204929 314 17173831 SGTC_111 0083-0039 52.457 µM 0.57019654378496 0.300511804733043 no 1007 0.284272200004079 310 759313 SGTC_545 4218-0007 221 µM 0.569751266892895 0.300657513668736 no 1008 0.284423206469439 328 2840508 SGTC_573 3702-0553 84.7 µM 0.569199259168326 0.300838192627153 no 1009 0.284610461682211 303 1222756 SGTC_2477 5967686 25.23 µM 0.568986488192879 0.300907848275211 no 1010 0.284682654782009 319 776118 SGTC_1290 0986-0249 10.2 µM 0.568475534583358 0.301075150809525 no 1011 0.284856056813541 324 53329 SGTC_2716 st080858 38.6235 µM 0.56838712673018 0.301104102618703 no 1012 0.284886064848575 305 5296050 SGTC_2881 9058953 51.95 µM 0.566841792673739 0.301610371197873 no 1013 0.285410836750492 266 17122249 SGTC_1765 st044815 90.4 µM 0.565728413311522 0.301975363755776 no 1014 0.28578920849466 319 645695 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.564324823927175 0.302435776638942 no 1015 0.286266545118124 301 115019 SGTC_2448 5185112 27.17 µM 0.561634056148805 0.303319295573136 no 1016 0.287182686030323 300 5718189 SGTC_1519 esterone 74 µM 0.561098044427444 0.303495433785343 no 1017 0.287365350608784 321 698 A steroid. SGTC_2241 6772625 37.8075 µM 0.56044896776254 0.303708787276814 no 1018 0.287586619536596 307 2285411 SGTC_1164 k060-0068 93.7 µM 0.56026852817028 0.303768110213093 no 1019 0.287648145333917 312 5963676 SGTC_1669 st015249 58.4 µM 0.560250254136524 0.303774118436401 no 1020 0.287654376710731 324 722793 SGTC_1738 st035555 74 µM 0.5593502875399 0.30407007929449 no 1021 0.28796134084669 344 5331140 SGTC_2958 9077254 16.72 µM 0.558178379572631 0.304455662645415 no 1022 0.288361291462113 301 16457351 SGTC_780 0109-0199 192 µM 0.558097595636751 0.304482250342621 no 1023 0.288388871178593 317 610414 SGTC_1664 st014217 9.02 µM 0.556532882759302 0.30499743403092 no 1024 0.288923310863315 326 3982782 SGTC_2192 5915882 198.485 µM 0.552935814140008 0.306183238701652 no 1025 0.290153681231307 317 2876149 SGTC_505 gw-5074 63.9 µM 0.552788843725191 0.306231732085959 no 1026 0.290204004340332 318 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_3257 9139206 32.98 µM 0.552375190651 0.306368236535849 no 1027 0.290345662333893 316 4910041 SGTC_1236 0330-0013 258 µM 0.552214808735519 0.306421169386945 no 1028 0.290400594799099 333 4617066 SGTC_1034 k072-0165 12.7 µM 0.551660475692636 0.306604153964594 no 1029 0.290590497063896 343 5835461 SGTC_2626 ethyl orsellinate 100 µM 0.55099021881344 0.306825469240615 no 1030 0.290820189843505 330 75653 A natural product. SGTC_2167 5876490 200 µM 0.547440024848628 0.307998897506098 no 1031 0.292038231920895 329 686534 SGTC_1126 isoteolin 1.0172 µM 0.546342987943914 0.308361893886402 no 1032 0.292415095918371 309 133323 SGTC_3178 9107506 49.47 µM 0.544514033737383 0.308967489590692 no 1033 0.293043896929601 323 8897194 SGTC_1433 4060-0023 7.6 µM 0.542194237507386 0.30973635832495 no 1034 0.293842352304016 311 3840627 SGTC_2804 7954240 19.48 µM 0.541724718095841 0.309892076412355 no 1035 0.294004079520234 319 828705 SGTC_1861 st057647 17.4 µM 0.540868976225062 0.3101759745359 no 1036 0.294298947899468 342 688668 SGTC_1524 corynanthine 62.1 µM 0.540723276173875 0.310224322788022 no 1037 0.294349166290038 344 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_536 3852-0578 10.6 µM 0.540376997315856 0.310339243098895 no 1038 0.294468533989021 331 2869208 SGTC_1289 0976-0073 69.1 µM 0.538819661798425 0.310856308201358 no 1039 0.295005647716357 342 3391136 SGTC_1276 0871-0068 94.2 µM 0.538665509941264 0.310907509901326 no 1040 0.295058838113817 333 3414906 SGTC_468 gf-109203x 121 µM 0.536020366628807 0.311786666739195 no 1041 0.295972237353187 302 2396 A protein kinase C inhibitor. SGTC_935 2996-0153 430 µM 0.534320395887267 0.312352247057979 no 1042 0.296559941712645 334 23738523 SGTC_626 0214-0009 33 µM 0.533730770234057 0.312548518931614 no 1043 0.296763908596006 329 3437874 SGTC_740 k014-0057 261 µM 0.530564161852073 0.313603513563739 no 1044 0.297860417937895 348 4012779 SGTC_368 fentichlor 4.58 µM 0.52914525013622 0.314076737258068 no 1045 0.298352346674254 362 7329 A pesticide. SGTC_3034 9090421 49.47 µM 0.528498828950609 0.314292427766624 no 1046 0.298576579824742 331 17173761 SGTC_796 1234-0020 70.7 µM 0.523360434066032 0.316009200199319 no 1047 0.300361726233797 317 46495034 SGTC_2536 dehydroabietamide 32.04 µM 0.521429774216962 0.316655276223401 no 1048 0.301033707287096 333 3983547 SGTC_2391 6285546 200 µM 0.521066722261707 0.316776830514305 no 1049 0.301160145979555 327 846083 SGTC_1068 loratadine 26.9 µM 0.519129182877775 0.317425876968542 no 1050 0.30183532947617 337 3957 A H1 histamine antagonist. SGTC_281 1672-3440 14.9 µM 0.518921873002422 0.317495355950453 no 1051 0.301907611999272 323 6833000 SGTC_2423 st077119 87.2 µM 0.515919033541055 0.31850246429023 no 1052 0.302955479929407 317 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2262 9014885 67.46 µM 0.513456999164093 0.31932919664882 no 1053 0.303815841450015 329 6457424 SGTC_3229 9132204 49.47 µM 0.512710867963737 0.319579919526334 no 1054 0.304076793153164 348 17682924 SGTC_276 colchicine 750 µM 0.51253718501676 0.319638294142227 no 1055 0.304137551305186 350 2833 A microtubule depolymerizer. SGTC_1832 st054113 55 µM 0.512012520853115 0.31981466022898 no 1056 0.304321123324344 319 1251267 SGTC_306 1672-3436 11.6 µM 0.510666711243652 0.32026724093523 no 1057 0.304792227081357 354 6797378 SGTC_1345 1488-0192 31.4 µM 0.510203400722647 0.32042310900709 no 1058 0.304954484972158 346 658348 SGTC_2641 levomentholum 100 µM 0.509848189675953 0.320542631444134 no 1059 0.305078910879572 340 16666 SGTC_112 phenothiazine 287.218 µM 0.509847444771836 0.32054288211118 no 1060 0.305079171833685 357 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2427 5545055 42.75 µM 0.507579532019235 0.321306434518091 no 1061 0.305874123882234 339 5372858 SGTC_960 1222-0186 7.7 µM 0.505630026473743 0.321963391117332 no 1062 0.306558199320151 340 3126296 SGTC_1420 4'-methoxyflavone 42 µM 0.505577716928277 0.321981026395369 no 1063 0.306576563879727 336 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_865 0488-0499 301 µM 0.505457774812025 0.322021464363587 no 1064 0.306618674359376 319 9634651 SGTC_746 1095-0025 46.6 µM 0.504738623977148 0.322263967155641 no 1065 0.306871214567264 345 6749286 SGTC_279 1273-0055 2.93 µM 0.504444483066492 0.322363175379265 no 1066 0.306974532823072 351 2847562 SGTC_595 3909-8003 73.7 µM 0.503531435089952 0.322671209944811 no 1067 0.307295342466752 340 699517 SGTC_1476 4112-3294 3.34 µM 0.502790568593452 0.322921245204261 no 1068 0.307555762644599 332 704369 SGTC_2206 7254556 146.969 µM 0.50209770552857 0.323155152220158 no 1069 0.307799397053742 322 4398905 SGTC_533 1222-0222 6.71 µM 0.500685528503412 0.323632112410882 no 1070 0.308296229286816 361 3982874 SGTC_372 0155-0182 15.9 µM 0.500449939594129 0.323711710364134 no 1071 0.308379148418286 316 771486 SGTC_1778 st046819 58.9 µM 0.498369964370503 0.324414817005588 no 1072 0.309111651422595 357 671715 SGTC_3254 9136651 49.47 µM 0.498068107228967 0.324516907716091 no 1073 0.30921801936351 351 16454030 SGTC_1751 st044839 27.194 µM 0.497997395589326 0.324540824914479 no 1074 0.30924293893129 312 5291326 SGTC_2452 5863136 48.41 µM 0.497666525814596 0.324652746486159 no 1075 0.309359552775685 322 2184096 SGTC_404 fumagillin 50 µM 0.494041232442219 0.325880090761777 no 1076 0.310638530024839 334 12015870 A methionine aminopeptidase binder. SGTC_447 ml7 120 µM 0.489761068241054 0.327331573519603 no 1077 0.312151491377451 366 4216 Selective myosin light chain kinase inhibitor. SGTC_2221 6807166 181.081 µM 0.488735663533178 0.327679696247647 no 1078 0.312514425777678 331 674925 SGTC_427 1354-0053 47.3 µM 0.488670780576191 0.327701728917817 no 1079 0.312537396742791 361 6813657 SGTC_2474 5321570 43.32 µM 0.486754708078874 0.328352650578662 no 1080 0.31321608526042 368 2841384 SGTC_3314 9135860 59.4275 µM 0.485780215317037 0.328683902117065 no 1081 0.313561501612068 349 25252478 SGTC_1132 3456-3614 2.5 µM 0.485573711653154 0.328754114556712 no 1082 0.313634719412303 343 3125502 SGTC_2859 9028643 45.46 µM 0.485321784140135 0.328839779553178 no 1083 0.313724052603985 319 17151580 SGTC_2205 7238770 200 µM 0.485288235731478 0.328851187974723 no 1084 0.313735949653396 349 279867 SGTC_715 0868-0130 184 µM 0.485003673904191 0.328947962054941 no 1085 0.313836869713017 343 2876258 SGTC_2325 6158266 200 µM 0.484237346545635 0.329208632462784 no 1086 0.314108717517702 325 3623240 SGTC_346 4513-0042 7.16 µM 0.484111052635017 0.329251599996403 no 1087 0.314153528845185 339 2827372 SGTC_1630 st005209 31.3 µM 0.483120890901748 0.32958854952357 no 1088 0.3145049507565 345 3367314 SGTC_326 k292-0812 17.5 µM 0.482984018885899 0.329635137616505 no 1089 0.314553541737008 360 3579357 SGTC_2820 7989630 71.43 µM 0.482853910428812 0.329679426000405 no 1090 0.314599734562375 314 2984098 SGTC_1995 st072814 61.1 µM 0.481991446763838 0.329973065454032 no 1091 0.314906011170898 333 5769371 SGTC_1337 1486-1011 40.3 µM 0.477778437104305 0.331408954896825 no 1092 0.316403955011169 334 X1337 SGTC_262 fenpropimorph 62.5 µM 0.477663379985209 0.331448203884459 no 1093 0.316444906228045 360 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1065 prochlorperazine maleate 2.48 µM 0.473723889760904 0.332793181136723 no 1094 0.317848407579291 358 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2487 5918373 44.05 µM 0.473250354998168 0.332954995539741 no 1095 0.318017288145877 362 2876279 SGTC_12 0849-0099 9.267 µM 0.472679976245685 0.333149944388761 no 1096 0.318220757225515 363 6071388 SGTC_918 glabranin 770.725 nM 0.472506215605099 0.333209342725902 no 1097 0.318282753114243 347 124049 Also referred to as licorice root. SGTC_3035 9091303 49.47 µM 0.472331097303138 0.33326920939891 no 1098 0.31834523855171 342 25237002 SGTC_1692 fluoroquinolonic acid 71 µM 0.472054907879953 0.333363637299715 no 1099 0.318443798531494 358 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2984 9022109 38.96 µM 0.470169889160107 0.334008398341704 no 1100 0.319116822495245 355 6459207 SGTC_1491 4138-0063 26.5 µM 0.469762011193271 0.334147975504004 no 1101 0.319262529165515 361 23883227 SGTC_2803 7707263 71.43 µM 0.469336318075506 0.33429367353348 no 1102 0.31941462973718 346 2199229 SGTC_1515 3460-0031 42.1 µM 0.469192439005602 0.334342923333055 no 1103 0.319466044744038 337 2876596 SGTC_2461 5755302 26.15 µM 0.468950466881981 0.334425756810965 no 1104 0.319552521008654 375 2788904 SGTC_3186 9110464 49.47 µM 0.468603484932725 0.334544552006408 no 1105 0.319676542925094 359 17018021 SGTC_3260 9137109 49.47 µM 0.467907158624679 0.334783001181851 no 1106 0.319925491988698 333 17478346 SGTC_2317 5986382 200 µM 0.467873002202131 0.334794699382875 no 1107 0.319937705606472 380 877883 SGTC_3113 9123498 49.47 µM 0.467555172791698 0.334903560164244 no 1108 0.320051364070649 364 8897275 SGTC_955 1216-0110 33 µM 0.467545417752466 0.334906901613836 no 1109 0.320054852821756 361 3619719 SGTC_282 k297-0036 65.7 µM 0.465000632203745 0.335779027352408 no 1110 0.32096550192945 352 5061378 SGTC_2327 6189656 200 µM 0.464765878622097 0.335859524627869 no 1111 0.321049562668349 383 5349088 SGTC_930 2810-3379 265 µM 0.462743767666678 0.336553220297966 no 1112 0.321774021065478 363 1015764 SGTC_725 1497-0963 19 µM 0.462170964588638 0.336749824643871 no 1113 0.32197936166009 358 3549977 SGTC_2293 7624732 200 µM 0.461938110702101 0.336829760309029 no 1114 0.322062851540147 347 894453 SGTC_1250 0485-0349 40.2 µM 0.461082756595087 0.337123455328012 no 1115 0.322369616252989 352 6842794 YDL195W SEC31 SGTC_1101 ebselen 5.29 µM 0.460789348190629 0.337224223137776 no 1116 0.322474872302887 371 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_3140 9094243 49.47 µM 0.460644907028459 0.33727383411728 no 1117 0.322526693722648 382 19291112 SGTC_3051 9093778 49.47 µM 0.458484281574681 0.33801627806701 no 1118 0.32330227635136 382 17217378 SGTC_1306 1185-0270 9.02 µM 0.457805507969337 0.338249651634926 no 1119 0.323546089153779 370 1548076 SGTC_1521 st012942 49.4 µM 0.456903881110714 0.338559741936891 no 1120 0.323870067128406 322 24207259 SGTC_2707 st078556 66.6 µM 0.456444977439929 0.338717611566284 no 1121 0.324035014425799 339 17250899 SGTC_1520 flindersine 88 µM 0.453502965791741 0.339730379138874 no 1122 0.325093304115585 369 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_3026 9090633 49.47 µM 0.453240198218049 0.339820891540007 no 1123 0.325187894749133 339 25236842 SGTC_2828 7998861 71.43 µM 0.452140008302068 0.340199961029381 no 1124 0.325584061557844 312 2988188 SGTC_1795 st049545 62.3 µM 0.45142631626438 0.340445949429957 no 1125 0.325841159982417 325 5291882 SGTC_2969 9091408 28.7 µM 0.450531196544826 0.340754566525162 no 1126 0.326163732507532 351 4286311 SGTC_283 0987-0079 11.7 µM 0.449959849851606 0.340951609743317 no 1127 0.326369695629726 369 411556 SGTC_2504 purpurogallin 52.29 µM 0.449690782050658 0.341044419546848 no 1128 0.32646670945073 362 5281571 An antioxidant. SGTC_1729 st035615 45.989 µM 0.449275982722067 0.34118751550286 no 1129 0.326616290542146 341 17385451 SGTC_455 paf C-16 10 µM 0.447149347063639 0.341921512867728 no 1130 0.327383615608275 356 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1140 3229-1848 2.98 µM 0.446796108690001 0.342043489252997 no 1131 0.327511140587559 375 2849525 SGTC_2996 9066192 71.4286 µM 0.446326820689264 0.342205564116478 no 1132 0.327680592560743 336 6472854 SGTC_1469 k284-2957 126 µM 0.444720315442324 0.342760612055293 no 1133 0.328260943042757 347 23884841 SGTC_971 1315-0384 26.7 µM 0.444415718178453 0.342865888816342 no 1134 0.328371025705234 372 6769120 SGTC_3171 9103192 49.47 µM 0.443229795238725 0.343275890898274 no 1135 0.328799764859747 369 13018434 SGTC_40 0327-0103 19.753 µM 0.442066497874164 0.343678250075433 no 1136 0.329220543347547 352 409036 SGTC_676 falcarinol 140 µM 0.441224761788848 0.34396949872209 no 1137 0.329525144291394 375 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2400 5203494 178.7 µM 0.440881132969133 0.344088424171855 no 1138 0.329649526564873 357 6777674 SGTC_1961 st076550 68.7 µM 0.439003106660373 0.344738656777622 no 1139 0.33032964264011 362 1579337 SGTC_1993 st073995 70.8 µM 0.436303225326142 0.345674245575081 no 1140 0.331308371037215 356 3098394 SGTC_3133 9127736 49.47 µM 0.436043827073325 0.345764184508092 no 1141 0.331402465794281 365 27243420 SGTC_375 3970-0961 9.27 µM 0.435215983220287 0.346051273910716 no 1142 0.331702831061024 342 2898222 SGTC_1792 st045773 43.6 µM 0.435197105734446 0.34605782149947 no 1143 0.331709681612012 340 2919270 SGTC_972 1319-0219 195 µM 0.434192757697651 0.34640624235898 no 1144 0.332074235900968 380 23903702 SGTC_2381 9035592 200 µM 0.433520136432901 0.346639655772475 no 1145 0.332318470236935 352 4749657 SGTC_846 0335-0850 148 µM 0.433018034131137 0.346813933563407 no 1146 0.332500834165028 365 6819598 SGTC_3297 9117502 71.43 µM 0.431571871416876 0.347316072148803 no 1147 0.33302630298597 333 7453720 SGTC_61 0978-8327 98.565 µM 0.431394991618226 0.347377507012567 no 1148 0.333090595479824 368 6150059 YHR072W ERG7 SGTC_1363 1636-0063 10.4 µM 0.4312529066616 0.347426859644868 no 1149 0.333142244253709 361 6072185 SGTC_793 0488-0545 106 µM 0.429381058332205 0.348077279780299 no 1150 0.333822968043094 368 292548 SGTC_1916 st067606 49.2 µM 0.42884084635922 0.348265073065914 no 1151 0.334019525532852 371 19590279 SGTC_1806 st050005 60.3 µM 0.427432164441255 0.348754946504157 no 1152 0.334532292097456 356 5194765 SGTC_2565 isoliquiritigenin 100 µM 0.426300291627279 0.349148741556578 no 1153 0.334944522710079 325 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_3206 9114350 49.47 µM 0.425974533086083 0.349262107832058 no 1154 0.335063201589318 354 17087243 SGTC_1640 st009078 66.4 µM 0.425547498320617 0.349410739321607 no 1155 0.335218801909147 383 690618 SGTC_2819 7996655 46.38 µM 0.424009757488385 0.349946148525828 no 1156 0.335779348616681 393 6456960 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.423145996399699 0.350247023065712 no 1157 0.336094372528099 390 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.422884567167296 0.350338105445173 no 1158 0.336189741580284 400 6728940 SGTC_974 1326-0144 138 µM 0.421138118529493 0.350946791645828 no 1159 0.336827114063544 378 5411856 SGTC_1026 k007-1105 30.6 µM 0.420455169208094 0.351184922762701 no 1160 0.337076486423232 349 7066794 SGTC_914 3820-6779 408 µM 0.418923352200388 0.351719249923149 no 1161 0.337636074952769 336 2893481 SGTC_1264 0783-0040 158 µM 0.417398901620852 0.352251298495413 no 1162 0.338193329075885 378 2855798 SGTC_1461 k072-0203 53.8 µM 0.417293452388435 0.352288112046749 no 1163 0.338231888563377 353 5418714 SGTC_1731 st035964 63 µM 0.417069779384617 0.352366203470366 no 1164 0.338313684404121 373 6739575 SGTC_1394 3474-0001 65.7 µM 0.416591826042605 0.352533093176651 no 1165 0.338488494569655 357 5017666 YIL048W NEO1 SGTC_2201 6605497 169.863 µM 0.415270688639283 0.352994549904934 no 1166 0.338971878060235 349 670741 SGTC_962 1254-0300 21.5 µM 0.413814682141583 0.353503365258531 no 1167 0.33950491528728 349 7340576 SGTC_2663 amphotericin b 100 µM 0.413608189236497 0.353575547398732 no 1168 0.339580537415614 372 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1777 st045864 34.765 µM 0.413066897056437 0.3537647877394 no 1169 0.339778800865545 404 4691462 SGTC_906 1165-0455 526 µM 0.412438306843655 0.353984593564568 no 1170 0.340009095302825 370 3252859 SGTC_1273 0849-0096 14.1 µM 0.411393328948588 0.354350109780058 no 1171 0.340392072373473 386 5286025 SGTC_1849 st056239 19.2 µM 0.411295098996606 0.354384475919946 no 1172 0.340428081434938 358 5393181 SGTC_1475 4092-1048 11.7 µM 0.410221984713831 0.354759986399028 no 1173 0.34082155755567 380 2881759 SGTC_2421 5690543 90.72 µM 0.409196003420725 0.355119135838328 no 1174 0.341197913551587 391 3397993 SGTC_3071 9117417 49.47 µM 0.408808036688676 0.35525497893092 no 1175 0.341340270799586 383 45595590 YGL055W OLE1 SGTC_154 3389-1638 511.116 µM 0.406697069639592 0.355994437172507 no 1176 0.342115246502871 402 5238686 SGTC_3286 9117135 37.221 µM 0.40591388549683 0.356268919567711 no 1177 0.342402937569531 367 3438150 SGTC_2992 9074591 71.4286 µM 0.403989934786725 0.356943522192958 no 1178 0.34311006035756 363 17741321 SGTC_2388 9080168 200 µM 0.40388415480332 0.356980625255804 no 1179 0.343148954365728 397 15943073 SGTC_402 epigallocatechin gallate 10 µM 0.403746093692868 0.357029053182805 no 1180 0.343199720249787 382 65064 An antioxidant. SGTC_2384 9036245 200 µM 0.401457708535982 0.35783208888918 no 1181 0.344041584530718 361 6462766 SGTC_787 4152-0075 138 µM 0.400946139321402 0.358011694002996 no 1182 0.344229889506275 355 9566539 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.400791976534013 0.358065824662168 no 1183 0.344286643303765 375 1377 SGTC_2345 9052315 157.45 µM 0.400594315900009 0.358135232748032 no 1184 0.344359415616057 364 6469265 SGTC_448 monastrol 171 µM 0.39952089962756 0.358512242269542 no 1185 0.34475471365172 383 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1027 k015-0025 8.67 µM 0.398201824525612 0.358975721939619 no 1186 0.34524071057948 363 3598955 SGTC_258 haloperidol 50.781 µM 0.397881570733936 0.359088279961692 no 1187 0.345358742682519 377 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3096 9117468 49.47 µM 0.397239767493578 0.35931388819984 no 1188 0.345595329678278 372 41316311 SGTC_1440 4100-1550 40 µM 0.395532884570681 0.359914134394007 no 1189 0.346224828787682 396 742806 SGTC_2398 5228213 48.84 µM 0.39523249106351 0.360019807241808 no 1190 0.346335658071571 393 80771 YMR134W ERG29 SGTC_1459 k035-0031 35.7 µM 0.395049632207945 0.360084138824579 no 1191 0.34640312974187 365 3877128 YMR208W ERG12 SGTC_1014 4130-3005 69.3 µM 0.395039867068922 0.360087574410085 no 1192 0.346406733041865 381 743608 SGTC_1945 st075991 56.6 µM 0.394704766353107 0.360205476880582 no 1193 0.346530392381068 337 1084980 SGTC_1657 st012939 43.4 µM 0.393591747725819 0.360597178839082 no 1194 0.346941237410552 372 24207257 SGTC_3239 9133757 49.47 µM 0.392077609380539 0.361130280747912 no 1195 0.347500435430937 403 17036923 SGTC_3070 9117005 49.47 µM 0.391938473608574 0.361179281597703 no 1196 0.347551837403423 370 8779016 SGTC_553 k007-0256 45.7 µM 0.391084593812638 0.361480050926665 no 1197 0.347867353982842 364 6287000 SGTC_711 k292-0785 179 µM 0.387149980741926 0.362867076745922 no 1198 0.349322588888286 365 4146315 SGTC_1617 st002906 78 µM 0.386940875898697 0.362940840732791 no 1199 0.349399989536227 395 5150859 SGTC_472 calcifediol 10 µM 0.386594216695624 0.363063139704901 no 1200 0.349528320049225 375 5283731 A vitamin D metabolite. SGTC_358 0075-0058 9.45 µM 0.386168872398167 0.363213217313305 no 1201 0.349685802663092 414 1069125 SGTC_2158 5657123 3.6195 µM 0.384626091837323 0.363757744935054 no 1202 0.350257230039109 414 2858827 SGTC_2862 9027634 71.43 µM 0.384437820777813 0.363824214467875 no 1203 0.350326986621201 344 5012562 SGTC_2909 7941780 10.49 µM 0.384420426708994 0.363830355690917 no 1204 0.350333431577571 369 1243215 SGTC_185 k048-0037 25.491 µM 0.383772855461742 0.364059014797149 no 1205 0.350573404275668 373 6827589 SGTC_3333 9141820 12.094 µM 0.383326453115779 0.364216668827897 no 1206 0.350738863859312 414 1939433 SGTC_2020 4017018 200 µM 0.382536141486055 0.364495836185434 no 1207 0.351031863268047 392 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1482 3346-2049 8.48 µM 0.382142512608366 0.364634907321297 no 1208 0.351177829938544 370 3826804 SGTC_2779 methotrexate 400 µM 0.381123248946142 0.364995101246856 no 1209 0.351555898420259 406 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2183 6420625 130.508 µM 0.380432432614407 0.365239294122695 no 1210 0.351812221724672 371 2897619 SGTC_273 hydroxyurea 18.1 mM 0.379712036441054 0.365494001224308 no 1211 0.352079592214258 391 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_59 0330-0160 1.33 µM 0.3794536346013 0.365585377615128 no 1212 0.352175514255539 379 4293482 SGTC_3180 9109287 49.47 µM 0.378523765896821 0.365914262066199 no 1213 0.35252077109998 367 18891271 SGTC_3261 9137475 49.47 µM 0.378255706883375 0.366009089936831 no 1214 0.352620323010673 377 17027690 SGTC_2576 guaiol 23.12 µM 0.375871619398807 0.366852838155195 no 1215 0.353506170219028 366 227829 SGTC_484 loperamide 105 µM 0.375774033301351 0.366887388419504 no 1216 0.353542446898906 370 3955 An opioid-receptor agonist. SGTC_2373 9071805 200 µM 0.375131801696575 0.367114796791946 no 1217 0.353781223406349 385 10149009 SGTC_338 4055-0136 114 µM 0.372865838292364 0.36791752584121 no 1218 0.35462414927417 367 2900563 SGTC_26 0302-0163 425.158 µM 0.372217888419914 0.368147171650035 no 1219 0.354865314206946 406 3100915 SGTC_926 2268-1401 59.4 µM 0.371271892645234 0.368482535222739 no 1220 0.355217515337267 383 2931578 SGTC_671 0560-0003 407 µM 0.371225999514089 0.368498807279914 no 1221 0.355234604833756 406 3238678 SGTC_802 4112-3352 742 µM 0.370178371174436 0.368870322772158 no 1222 0.355624795511325 346 704594 SGTC_79 0052-0007 94.094 µM 0.369988009734475 0.368937842919565 no 1223 0.355695712162631 405 2801472 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.368918083914612 0.369317414879279 no 1224 0.356094391826316 369 5355888 SGTC_2447 5741742 33.78 µM 0.368639327724379 0.369416328688372 no 1225 0.356198288837011 363 1776504 SGTC_3111 9122088 49.47 µM 0.367797830154799 0.369714977984801 no 1226 0.356511993539592 388 16876704 SGTC_2435 5706476 10.6 µM 0.367704421569978 0.36974813374272 no 1227 0.356546821630696 367 5725375 SGTC_1471 k673-0312 37 µM 0.367409399668601 0.369852859327411 no 1228 0.356656830612797 376 24099884 SGTC_166 k072-0058 166.424 µM 0.365804485550455 0.37042273362663 no 1229 0.357255486272304 395 5846229 SGTC_2737 bleomycin 30.5 nM 0.36435751236055 0.37093677004509 no 1230 0.357795529140357 398 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_3028 9087778 49.47 µM 0.363941243994236 0.3710846918659 no 1231 0.357950942629877 384 17217395 SGTC_1760 st045453 10.4495 µM 0.36354946037602 0.37122393038318 no 1232 0.358097236266791 427 3323419 YIL048W NEO1 SGTC_1695 st026914 34.495 µM 0.36289234950691 0.371457503109935 no 1233 0.358342650981613 375 3289191 SGTC_2581 avocatin a 64 µM 0.362772961774858 0.371499945048533 no 1234 0.358387245642791 395 6710728 A skin care supplement. SGTC_2160 5660466 132.927 µM 0.362411082809387 0.371628601350548 no 1235 0.35852242936806 401 2859134 SGTC_1156 4092-0367 4.88 µM 0.361248782745924 0.372041922708813 no 1236 0.358956738732736 381 1357585 SGTC_2965 9082772 38.63 µM 0.36123541433106 0.372046677461717 no 1237 0.358961735086329 346 16459634 SGTC_1080 nisoldipine 24.4 µM 0.360856677680422 0.372181391079288 no 1238 0.35910329534012 416 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_94 0334-0113 514.748 µM 0.360204618418962 0.372413360024399 no 1239 0.359347060603496 387 6795178 SGTC_2356 9061756 188.97 µM 0.35885531184072 0.372893520419491 no 1240 0.359851665932275 381 20104043 SGTC_731 3966-0296 387 µM 0.358378145988366 0.3730633706194 no 1241 0.360030172002715 383 660956 SGTC_2591 skatole 100 µM 0.357364020067897 0.373424437058631 no 1242 0.360409654293732 406 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1925 st057770 10.1 µM 0.353976081808142 0.374631473058465 no 1243 0.361678404098441 363 5989122 SGTC_882 0843-0131 351 µM 0.353540961940848 0.374786584505815 no 1244 0.361841462831941 390 5425421 SGTC_1376 2910-0861 41.3 µM 0.353324314797896 0.374863822394293 no 1245 0.361922659491741 387 1112859 SGTC_1970 st070122 35.8 µM 0.352304667264052 0.375227409074769 no 1246 0.362304894142045 407 102928 SGTC_1463 k081-0032 34.1 µM 0.351939015375279 0.375357820527016 no 1247 0.362441999315886 382 977755 SGTC_652 0437-0092 114 µM 0.351696542527045 0.37544430745631 no 1248 0.362532926892468 364 3091274 SGTC_2770 toltrazuril 17.5 µM 0.350645755329422 0.375819181961158 no 1249 0.362927062768481 387 68591 Kills coccidiodes. SGTC_56 0957-0365 83.25 µM 0.350334922475328 0.375930095893121 no 1250 0.363043679766686 384 6752360 SGTC_1416 3966-0321 25.3 µM 0.34907891567566 0.376378378864491 no 1251 0.363515032494584 371 582530 YLR208W SEC13 SGTC_2808 7946468 45.46 µM 0.349072834101014 0.376380549853227 no 1252 0.363517315284024 407 2970879 SGTC_2247 cerulenin 830 nM 0.347409041012037 0.37697463415632 no 1253 0.364142021046114 364 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1176 0848-0131 83.3 µM 0.347028859581904 0.377110425048061 no 1254 0.364284818832498 411 6769040 SGTC_3029 9088683 49.47 µM 0.346282846300302 0.377376925695615 no 1255 0.364565079383563 368 25236615 SGTC_2121 5257820 149.641 µM 0.344214770829357 0.378116015743419 no 1256 0.36534238738459 389 791256 SGTC_411 enrofloxacin 100 µM 0.343385142777181 0.378412634288213 no 1257 0.365654367579143 423 71188 A bacterial gyrase inhibitor. SGTC_529 4076-0302 30.3 µM 0.342455300985065 0.378745167609117 no 1258 0.366004138612987 401 5816522 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.341146315179582 0.379213443876484 no 1259 0.366496717896596 382 5357218 A potent inhibitor of glutathione S-transferases. SGTC_222 nsc-310342 10.666 µM 0.341078054949909 0.379237868144153 no 1260 0.366522410676463 427 432556 SGTC_2666 tannic acid 100 µM 0.339804080280187 0.379693798773857 no 1261 0.367002037475845 380 16134267 A thiamine antagonist. SGTC_1709 st033179 39.1045 µM 0.339793878269178 0.37969745055026 no 1262 0.367005879174597 395 573381 SGTC_911 3456-4043 236 µM 0.33846918259386 0.380171712061744 no 1263 0.367504823410423 392 914281 SGTC_3039 9090270 49.47 µM 0.338114320936116 0.380298788651237 no 1264 0.367638519444995 395 17173750 SGTC_2848 9016370 25.97 µM 0.337789610956375 0.380415079192378 no 1265 0.367760869729004 397 7894410 SGTC_2898 9056270 58.44 µM 0.337489829569495 0.380522451487026 no 1266 0.367873838867612 396 19154699 SGTC_2483 5729050 27.16 µM 0.332874117003841 0.382176812285905 no 1267 0.369614653980721 424 2865180 SGTC_1667 st014849 34.6 µM 0.332354178490353 0.382363303823187 no 1268 0.369810917046651 394 5348460 SGTC_2944 9067346 25.62 µM 0.331334908266303 0.382728974798873 no 1269 0.370195763030147 397 6473075 SGTC_1448 4255-0083 152 µM 0.331266005800976 0.382753697861219 no 1270 0.370221783237156 418 5399660 SGTC_1338 1486-1223 76 µM 0.331156629882162 0.382792944283644 no 1271 0.370263088988295 414 3444526 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.331125540237973 0.382804100133578 no 1272 0.370274830247157 376 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2708 st078559 56 µM 0.330696510836151 0.3829580580289 no 1273 0.370436869054631 392 17250902 SGTC_323 4013-0906 34.3 µM 0.329663064177686 0.383328987914515 no 1274 0.370827282715685 403 2910086 SGTC_635 k038-0028 24.7 µM 0.329305554735908 0.383457331928323 no 1275 0.370962372993475 416 4035102 SGTC_1730 st033808 45.1 µM 0.326751184128392 0.384374708930617 no 1276 0.371928041923888 402 1045166 SGTC_1188 1403-0014 4.57 µM 0.323942007296643 0.385384345162214 no 1277 0.372990970033237 389 9614867 SGTC_2363 9053361 176 µM 0.32314249610393 0.385671837019486 no 1278 0.373293663968528 422 6469797 YMR079W SEC14 SGTC_1060 3448-7350 82 µM 0.322287251455614 0.385979439302799 no 1279 0.373617545096988 387 570178 SGTC_700 3453-2283 142 µM 0.32213898883442 0.38603277160021 no 1280 0.373673701234865 381 565664 SGTC_2389 9091542 195.52 µM 0.3219525704233 0.386099832166346 no 1281 0.3737443131142 392 3626624 YOL127W RPL25 SGTC_3235 9132602 49.47 µM 0.318335002461112 0.387401856669606 no 1282 0.375115418028816 404 4912240 SGTC_73 0327-0325 16.231 µM 0.318025728704391 0.387513228598277 no 1283 0.375232710306484 389 53298 SGTC_10 0279-0212 42.575 µM 0.317991810151353 0.387525443501262 no 1284 0.375245574642464 393 39851 YBR002C RER2 SGTC_1136 pergolide 1.05886 µM 0.317511425444977 0.387698453767284 no 1285 0.375427785699157 423 47811 A dopamine receptor agonist. SGTC_540 1187-0821 17.3 µM 0.314544717421333 0.388767404764875 no 1286 0.37655367948244 444 847520 SGTC_3226 9131256 49.47 µM 0.311356405209805 0.389917142622689 no 1287 0.377764845743229 384 17178073 SGTC_938 3126-1755 342 µM 0.311195318726551 0.389975257711085 no 1288 0.377826070799292 422 1777771 SGTC_3347 9188721 44.724 µM 0.31012697991401 0.39036074394538 no 1289 0.378232198018531 436 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2843 9000894 45.46 µM 0.310027579299195 0.390396615928432 no 1290 0.378269991846409 368 2242070 SGTC_1028 k015-0029 4.8 µM 0.309529189811772 0.390576490238614 no 1291 0.378459505677334 395 4588309 SGTC_3005 9076496 71.4286 µM 0.309003641335083 0.39076619189951 no 1292 0.378659378451157 416 21368410 SGTC_2276 7947513 42.08 µM 0.308542374913252 0.390932711774558 no 1293 0.378834830691506 411 2105100 SGTC_3069 9117009 49.47 µM 0.307999238115446 0.391128812971408 no 1294 0.37904145603705 390 41904981 SGTC_62 0180-0423 3.232 µM 0.306580731042425 0.391641099713935 no 1295 0.379581261091481 419 30102 YGL099W LSG1 SGTC_675 1309-0189 238 µM 0.306392191982032 0.391709203824775 no 1296 0.379653026292441 367 4246530 SGTC_1365 1672-3266 55.4 µM 0.306388769417062 0.39171044015494 no 1297 0.379654329090318 439 6415873 SGTC_1950 st077106 7.18 µM 0.305738527655309 0.391945346248828 no 1298 0.379901868105638 378 13831864 SGTC_366 0181-0206 4.31 µM 0.305730704713051 0.391948172601988 no 1299 0.379904846503039 403 274874 SGTC_2086 5274770 176.623 µM 0.305668291339807 0.391970722152572 no 1300 0.379928609151187 401 689278 SGTC_2916 7875993 68.79 µM 0.305127606557465 0.39216608326907 no 1301 0.380134483073489 424 1299250 SGTC_1197 1601-0112 267 µM 0.302217530782955 0.393218022378447 no 1302 0.38124312053836 408 7350313 SGTC_999 SEC7.066 22.7 µM 0.302185883812583 0.393229466480511 no 1303 0.381255182308424 416 740511 YDR170C SEC7 SGTC_868 0527-0199 213 µM 0.301422353860679 0.393505600306712 no 1304 0.381546225283013 392 2849450 SGTC_2967 9089538 49.85 µM 0.299595427180258 0.394166533243061 no 1305 0.382242886314918 399 728216 SGTC_2282 7944268 200 µM 0.298823750328232 0.394445796871658 no 1306 0.382537264160764 402 2970414 SGTC_1298 1079-1278 263 µM 0.295668923489296 0.395588066188016 no 1307 0.383741466039461 420 2840950 SGTC_1942 st076330 65.2 µM 0.295404014876479 0.395684022726991 no 1308 0.383842633328224 426 24208414 SGTC_507 nimesulide 162 µM 0.294822542699175 0.395894668688016 no 1309 0.384064722428659 428 4495 A COX2 inhibitor. SGTC_1465 k213-0056 144 µM 0.29373783342142 0.396287700145734 no 1310 0.384479121019631 387 24048857 YMR208W ERG12 SGTC_823 0417-1665 178 µM 0.293366684365801 0.396422205804258 no 1311 0.384620943870016 435 3429856 SGTC_2072 5231554 129 µM 0.290988578644138 0.397284331186903 no 1312 0.38553002732678 440 789545 SGTC_2351 9026858 72.31 µM 0.290382976625797 0.397503958099354 no 1313 0.385761632799867 419 1409300 SGTC_654 1124-0271 80.9 µM 0.290306997379742 0.397531514938638 no 1314 0.3857906930593 425 5403748 SGTC_360 0957-0399 1.01 µM 0.290028351794532 0.397632581012234 no 1315 0.385897273871195 407 6752301 YPR165W RHO1 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.289449887082268 0.397842414835766 no 1316 0.386118561782878 416 6708514 SGTC_1424 4048-1941 275 µM 0.289008678764093 0.398002479782966 no 1317 0.38628736806723 453 X1424 SGTC_1651 st011928 86.1 µM 0.288903964525154 0.398040471341839 no 1318 0.386327434892608 416 720198 SGTC_271 rotenone 740 µM 0.287356620737681 0.398601978391437 no 1319 0.386919636362009 432 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1094 duloxetine 25.4 µM 0.287238404734021 0.398644885792815 no 1320 0.386964890993867 389 60834 A selective serotonin reuptake inhibitor. SGTC_2656 pseudo-anisatin 100 µM 0.286606329402342 0.398874323136975 no 1321 0.387206883754724 429 6708809 A neurotoxin. SGTC_844 0330-0132 15.3 µM 0.286524907182774 0.398903881172164 no 1322 0.38723805979136 449 2828079 SGTC_2918 7977171 22.06 µM 0.284163409669736 0.399761407685075 no 1323 0.388142577465781 411 2236483 SGTC_3011 9081274 71.4286 µM 0.281902720749749 0.400582781003093 no 1324 0.389009051628365 406 6625322 SGTC_1843 st055809 45.5 µM 0.281872600813525 0.400593727419241 no 1325 0.389020599699545 396 16413835 SGTC_2870 9038528 12.99 µM 0.281769063232728 0.400631356429171 no 1326 0.389060297056975 420 6463316 SGTC_1741 st038134 10.228 µM 0.281563513224341 0.400706062889813 no 1327 0.389139110444143 426 1272587 SGTC_182 3448-4371 550.524 µM 0.279627358212792 0.401409929796407 no 1328 0.389881707633008 396 3491403 SGTC_530 4358-1714 28 µM 0.279095951578048 0.4016031726418 no 1329 0.39008559495692 440 1564641 SGTC_2993 9054257 71.4286 µM 0.278729043077471 0.401736610770816 no 1330 0.390226386146925 436 6470217 YGL055W OLE1 SGTC_2147 5545932 89.7195 µM 0.277986859006428 0.402006564996497 no 1331 0.390511223167126 444 797404 SGTC_2982 9019404 25.97 µM 0.277757144871128 0.402090128280499 no 1332 0.390599395275898 362 22333232 SGTC_684 1140-0066 328 µM 0.277458602692184 0.40219873588107 no 1333 0.390713994338376 404 6813534 SGTC_2780 5215298 71.43 µM 0.27685619124471 0.402417912024248 no 1334 0.390945266225955 425 2834131 SGTC_2312 7706453 155.7 µM 0.274888344691327 0.403134089656536 no 1335 0.391701010961176 415 976098 SGTC_651 3253-0966 34.4 µM 0.274066653174144 0.403433232223758 no 1336 0.392016699955401 414 781462 SGTC_2925 9010536 32.5 µM 0.273082234070375 0.403791691303327 no 1337 0.3923950015195 398 2994177 SGTC_2120 5538279 151.968 µM 0.272634304531607 0.40395482381889 no 1338 0.392567169663727 411 2058197 SGTC_2752 diclazuril 33.15 µM 0.271108856559755 0.404510505475577 no 1339 0.393153655018239 418 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1917 st066507 28.5 µM 0.27087778197619 0.404594696863347 no 1340 0.393242516902861 419 3156428 SGTC_1508 1080-0625 72.9 µM 0.270346201855286 0.404788393379619 no 1341 0.393446962101469 418 767111 SGTC_3162 9099653 49.47 µM 0.270029159089371 0.404903928146766 no 1342 0.393568910433197 413 25237511 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.269853431210452 0.404967969386839 no 1343 0.393636507457994 446 140250 A respiratory chain inhibitor. SGTC_2863 9028737 58.44 µM 0.26915898709147 0.405221073425615 no 1344 0.393903669760027 448 6460917 SGTC_544 k015-0020 52.4 µM 0.269038825388155 0.405264872786398 no 1345 0.393949902708711 409 3008304 SGTC_1038 k292-0204 154 µM 0.265233967111007 0.406652367732059 no 1346 0.395414614836966 398 4454212 SGTC_640 3381-0960 37.1 µM 0.263843394573159 0.407159753054991 no 1347 0.395950297465137 428 1745025 SGTC_831 k061-1017 217 µM 0.26264074578425 0.407598695380007 no 1348 0.396413745815228 448 1240153 SGTC_1912 st060209 90.8 µM 0.262624332504143 0.407604686696927 no 1349 0.396420071791103 461 688787 SGTC_365 0121-0052 13.6 µM 0.262348000636844 0.407705558979625 no 1350 0.39652657919801 400 3101739 SGTC_2096 5468907 200 µM 0.262170677859085 0.407770292172828 no 1351 0.396594929307157 447 759785 SGTC_1745 st081495 74 µM 0.261489910074193 0.408018835637435 no 1352 0.396857364758997 420 13842402 YBL026W LSM2 SGTC_1362 1611-0397 101 µM 0.261453513206074 0.408032124917803 no 1353 0.396871397040108 399 27816 SGTC_2220 6782180 200 µM 0.260482121778022 0.408386839892052 no 1354 0.397245952107589 437 833803 SGTC_596 1155-0152 116 µM 0.259775246021038 0.408645011078066 no 1355 0.397518573202135 431 280313 SGTC_3207 9114163 49.47 µM 0.259732444237096 0.408660644784399 no 1356 0.397535082194418 452 849233 SGTC_860 0443-0016 25.1 µM 0.259549805171161 0.408727356850008 no 1357 0.397605529613058 413 5337942 SGTC_1112 tnp00069 1.16933 µM 0.258970169321771 0.40893909633679 no 1358 0.397829128473248 433 145826 SGTC_1848 st056003 16.4 µM 0.256724447490095 0.409759703170166 no 1359 0.398695748770281 441 146492 SGTC_1090 efavirenz 20.7 µM 0.255418514420276 0.410237084867802 no 1360 0.399199936238173 434 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_3057 9095946 49.47 µM 0.25538247159944 0.410250262151915 no 1361 0.399213853841428 431 24540043 SGTC_130 0136-0219 337.655 µM 0.253581636427108 0.410908777649616 no 1362 0.399909392506777 460 234244 SGTC_578 3460-0051 92 µM 0.25322389761171 0.411039622778501 no 1363 0.400047600277085 465 2876744 SGTC_2238 6671620 73.2395 µM 0.25315303854764 0.411065541083362 no 1364 0.40007497724732 383 729941 SGTC_2649 anisomycin 9.56 µM 0.252522674870509 0.411296127927585 no 1365 0.400318544934143 424 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2266 7929956 200 µM 0.250730800330498 0.411951762219448 no 1366 0.401011122966539 417 2967153 SGTC_331 k048-0133 24.5 µM 0.249357559661721 0.412454387834424 no 1367 0.401542105445487 412 6813582 SGTC_2196 6573537 42.6665 µM 0.248985349791902 0.412590646711408 no 1368 0.401686056899212 448 2903087 SGTC_1963 st076565 50.3 µM 0.248943615488334 0.412605925494644 no 1369 0.401702198393284 440 4914280 SGTC_2908 7930301 100 µM 0.248770021863255 0.412669478937078 no 1370 0.401769340655646 404 2223178 SGTC_904 1141-0088 396 µM 0.248203383289369 0.412876943908316 no 1371 0.401988524379147 435 1378119 SGTC_1588 farnesol 29.9 µM 0.247992167814787 0.412954283052441 no 1372 0.402070233369013 423 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_21 0849-0113 22.993 µM 0.247341224633581 0.413192655144148 no 1373 0.402322078518672 421 1560156 SGTC_2701 st077767 14.721 µM 0.246322844280945 0.413565645035874 no 1374 0.402716163728404 419 5721188 SGTC_622 1348-1566 26.3 µM 0.245903586111631 0.413719224357379 no 1375 0.40287843387024 437 7340407 SGTC_2497 7-hydroxyflavone 100 µM 0.243444794972763 0.414620174136694 no 1376 0.403830422985711 454 5281894 SGTC_2142 5622915 118.518 µM 0.242729499851227 0.414882357022657 no 1377 0.404107476583431 428 5322196 SGTC_1333 1482-0047 286 µM 0.242661126794543 0.414907420337436 no 1378 0.404133961881732 454 3811116 SGTC_2058 5236698 133 µM 0.242286549622361 0.415044734158053 no 1379 0.404279067594325 407 766665 SGTC_201 4262-0159 12.803 µM 0.240339988223093 0.415758478246523 no 1380 0.405033348597024 455 1341029 SGTC_774 k060-0086 136 µM 0.23899379340927 0.416252249157513 no 1381 0.405555197726158 449 5911235 SGTC_1875 nocodazole 6 µM 0.237097621336982 0.416947970361155 no 1382 0.406290528830737 444 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2785 7756463 72.73 µM 0.235559763630659 0.417512414243242 no 1383 0.406887149415803 452 2201551 SGTC_3144 9087057 49.47 µM 0.234972592956914 0.417727969921464 no 1384 0.4071150026927 474 17249618 SGTC_2718 lomofungin 53.02 µM 0.234002490880968 0.418084157323001 no 1385 0.407491522451086 444 5351222 A RNA synthesis inhibitor. SGTC_1728 st035614 33.7865 µM 0.233487710349329 0.418273193957797 no 1386 0.407691355792853 429 15945546 SGTC_3172 9105863 49.47 µM 0.233235740176418 0.418365728804742 no 1387 0.407789177189813 456 2348785 SGTC_3084 9116877 49.47 µM 0.232875549836704 0.418498014837573 no 1388 0.407929022461334 457 27241325 SGTC_2060 5238662 140 µM 0.231382095388069 0.419046609590966 no 1389 0.408508986802658 424 790130 SGTC_559 1550-0661 158 µM 0.231077431384404 0.419158542031087 no 1390 0.408627323911196 449 5830875 SGTC_1880 MG-132 525 µM 0.230330873993761 0.419432852128553 no 1391 0.408917335747047 462 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2361 9034121 116 µM 0.230105366193811 0.419515718926243 no 1392 0.409004947575892 440 6496917 SGTC_2980 9014342 25.29 µM 0.229367090122898 0.419787036374897 no 1393 0.409291806319629 460 2996599 SGTC_789 1309-1135 70.6 µM 0.228297713538296 0.420180101294399 no 1394 0.409707400981198 419 3092424 SGTC_2425 5628681 7.85 µM 0.226890369750611 0.42069751226261 no 1395 0.410254495308771 457 5714958 SGTC_221 trifluoperazine 10.304 µM 0.226855109470333 0.420710477493669 no 1396 0.410268204725821 463 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_3146 9095609 49.47 µM 0.22613113132846 0.420976703783296 no 1397 0.4105497161642 424 17173999 SGTC_1557 sumaresinolic acid 42.3 µM 0.225454055584689 0.421225715503165 no 1398 0.410813031800125 420 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_880 0833-0487 87.2 µM 0.224873926147934 0.42143909783948 no 1399 0.411038676872272 423 76075 SGTC_2131 toluylene red 5.2905 µM 0.224477839309494 0.421584799162823 no 1400 0.411192754308803 407 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_798 1287-0182 476 µM 0.223860153363636 0.421812037573908 no 1401 0.411433060938666 466 1649755 SGTC_1867 st057372 64 µM 0.223092127060479 0.42209462050062 no 1402 0.411731902827096 427 688837 SGTC_1786 berberine 21.6 µM 0.222796857963735 0.422203270698915 no 1403 0.411846806766857 464 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2357 9067248 200 µM 0.222702931534551 0.42223783405785 no 1404 0.411883359812696 460 9150235 SGTC_393 acivicin 6.25 µM 0.221991077352199 0.422499803970536 no 1405 0.412160414646315 453 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1477 0139-0234 16 µM 0.220211823998726 0.423154737828397 no 1406 0.412853094213012 429 620880 SGTC_1254 0550-0035 264 µM 0.219462159204696 0.423430749228189 no 1407 0.413145026960349 458 15121435 SGTC_800 3448-7362 155 µM 0.2182924317601 0.423861494204836 no 1408 0.413600635431408 441 15991913 SGTC_2506 ethyl hematommate 54.16 µM 0.218118717210268 0.42392547129705 no 1409 0.413668307130817 432 3940691 An allergen. SGTC_3130 9127414 49.47 µM 0.217483522145491 0.424159423470055 no 1410 0.413915773558544 447 1494646 SGTC_2605 digitonin 300 nM 0.21743000362261 0.424179136392305 no 1411 0.413936625468755 455 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1802 st050112 57.9 µM 0.217087767798365 0.424305199440298 no 1412 0.414069973274341 433 4662563 SGTC_3319 9138450 16.7555 µM 0.215309458897541 0.424960366416941 no 1413 0.414763027717016 462 2029690 SGTC_478 N-arachidonylglycine 10 µM 0.213299877473726 0.425700988572553 no 1414 0.415546534558227 451 5283389 SGTC_36 0335-0881 14.2 µM 0.21281386517281 0.425880145684565 no 1415 0.415736074310357 442 23828853 SGTC_491 tetrandrine 80.3 µM 0.212034402112937 0.426167508515523 no 1416 0.41604009772923 458 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3302 9125395 16.351 µM 0.210003225575424 0.42691652147092 no 1417 0.416832577763374 448 17599668 SGTC_1375 2910-0797 186 µM 0.209743297557966 0.427012391132953 no 1418 0.416934015259583 474 742508 SGTC_2979 9012552 45.46 µM 0.208289867010137 0.427548541519362 no 1419 0.417501321550181 458 17100905 SGTC_2763 lisinopril 49.32 µM 0.206997914358644 0.42802523733219 no 1420 0.418005743663413 480 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3290 9121031 71.43 µM 0.206913233111406 0.428056486113349 no 1421 0.418038810813225 442 17014854 SGTC_2403 6032726 181.2 µM 0.20529746272882 0.428652818330368 no 1422 0.418669863145408 437 2881040 SGTC_2170 morpholine 200 µM 0.20503311738426 0.42875039578484 no 1423 0.418773125350866 440 121171 Reacts with secondary amines. SGTC_2627 acetyl isogambogic acid 100 µM 0.204795261717929 0.428838198861325 no 1424 0.418866044578687 447 6857789 A caspase activator and apoptosis inducer. SGTC_689 0833-0039 98 µM 0.204414194620441 0.428978874968315 no 1425 0.419014919333704 477 5374726 SGTC_405 ebelactone b 50 µM 0.203742713556761 0.429226783289627 no 1426 0.419277280816093 446 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_3353 9151644 39.2805 µM 0.20367204659123 0.42925287489684 no 1427 0.41930489394469 479 4909158 SGTC_3160 9100216 49.47 µM 0.200170337113543 0.430546158479394 no 1428 0.420673682612042 474 17191039 SGTC_2417 cerulenin 830 nM 0.199865406847665 0.43065881360823 no 1429 0.42079292293801 482 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_11 0438-0307 1.3 µM 0.198124962426158 0.431301920805591 no 1430 0.421473647373963 462 4011476 SGTC_1116 jasmonic acid  1.58368 µM 0.198113900046367 0.431306009021847 no 1431 0.421477974856428 467 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2531 methyl deoxycholate 70.07 µM 0.19730337234685 0.431605567866366 no 1432 0.421795070234084 453 16667744 Haematoxylin. SGTC_2358 9037157 4 µM 0.196128471049704 0.432039863505787 no 1433 0.422254806162141 464 2388925 SGTC_3000 9075062 71.4286 µM 0.195642959005524 0.432219354310204 no 1434 0.422444816778445 460 17057871 SGTC_1224 0823-0416 294 µM 0.195566838137938 0.432247496994504 no 1435 0.422474609176685 456 3598164 SGTC_259 usnic acid 108.925 µM 0.194854440607611 0.432510894488894 no 1436 0.422753450792203 477 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1754 st042065 16.137 µM 0.194094467826061 0.43279191522864 no 1437 0.42305095664732 454 1126236 YIL048W NEO1 SGTC_1678 st019265 80.2 µM 0.193995957548393 0.432828344592338 no 1438 0.423089523592945 459 5367020 SGTC_950 1165-0508 94.1 µM 0.191571149938365 0.433725224142965 no 1439 0.424039071463686 444 6148369 SGTC_29 0299-0004 12.984 µM 0.191264404301208 0.433838706588339 no 1440 0.424159223744014 485 16871 A napthoquinone isolated from Swertia calycina. SGTC_1359 1582-0056 520 nM 0.191185135885294 0.433868033316142 no 1441 0.424190274332884 459 3661189 SGTC_954 1189-0853 2.85 µM 0.191175626356045 0.43387155155618 no 1442 0.424193999385111 436 2828194 SGTC_2283 7944793 200 µM 0.190470687483392 0.434132372324205 no 1443 0.42447015535153 487 2970533 SGTC_719 2810-4230 27.3 µM 0.189837835977162 0.434366545875145 no 1444 0.424718103076217 473 721079 SGTC_2849 9019321 12.99 µM 0.189629884041745 0.434443499199606 no 1445 0.424799584003314 458 16489627 SGTC_2745 rifampicin 24.3 µM 0.188732570137806 0.43477558172471 no 1446 0.425151211517015 486 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2812 7970281 58.44 µM 0.186991017249156 0.435420235666826 no 1447 0.425833837961849 454 2233435 SGTC_2757 clomiphene 4.22 µM 0.18622811054413 0.435702687702316 no 1448 0.426132940253864 477 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1436 4092-1007 8.32 µM 0.186178185865634 0.435721172532154 no 1449 0.426152515016189 442 2881121 SGTC_1860 st056228 74.6 µM 0.185548528032089 0.435954318130994 no 1450 0.426399410574806 486 688679 SGTC_1783 st039459 87.517 µM 0.185381948786181 0.436016001734934 no 1451 0.426464732904671 483 729761 SGTC_1185 1319-0113 81.3 µM 0.185373049428896 0.436019297173838 no 1452 0.426468222752444 459 4672763 SGTC_747 3448-8087 38.7 µM 0.184438470828613 0.436365397037489 no 1453 0.426834746052713 463 5168703 SGTC_347 4534-1311 26.2 µM 0.182932208033474 0.436923309540403 no 1454 0.427425605469346 452 2862016 SGTC_1004 4084-0029 199 µM 0.182623907645304 0.437037518028664 no 1455 0.427546562110972 473 716894 YLR208W SEC13 SGTC_2048 5246248 200 µM 0.180651258363286 0.437768400863075 no 1456 0.428320659689206 481 677046 SGTC_2648 atorvastatin 78.68 µM 0.180082140893495 0.437979303164179 no 1457 0.428544041450747 481 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_3233 9132340 49.47 µM 0.179922882887979 0.438038323803297 no 1458 0.428606555203522 483 17682950 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.178621206949611 0.438520773375547 no 1459 0.42911757077482 435 5379071 SGTC_2248 tofa 1.1 µM 0.178072369778013 0.438724220294346 no 1460 0.429333070465204 466 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2375 9072683 200 µM 0.178000615458675 0.438750819900586 no 1461 0.42936124619672 472 16798029 SGTC_1668 st014914 51.6 µM 0.177902286658544 0.438787271219844 no 1462 0.429399857500328 482 2839556 SGTC_2732 terfenadine 20 µM 0.176554579540498 0.439286929861014 no 1463 0.429929136885693 489 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_3269 9137823 49.47 µM 0.176291253054039 0.439384568741894 no 1464 0.430032566734848 494 17682936 SGTC_2985 9022375 71.43 µM 0.1759474969899 0.439512035670455 no 1465 0.43016759508194 444 4939335 SGTC_1202 1988-0068 29.6 µM 0.175857692722427 0.439545336696072 no 1466 0.430202871796468 456 2850480 SGTC_277 nystatin 15.5 µM 0.175066165127083 0.439838867734711 no 1467 0.430513821987088 473 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2359 9039622 200 µM 0.174122060483156 0.440189023866345 no 1468 0.430884768132069 469 6463596 SGTC_74 000s-0487 160.283 µM 0.173749128441984 0.440327352414386 no 1469 0.431031312886597 396 677548 SGTC_169 k015-0017 16.025 µM 0.172248609235243 0.440884000831709 no 1470 0.431621042138505 470 1840002 SGTC_943 3253-1379 105 µM 0.171989261579392 0.440980223042425 no 1471 0.431722985610375 480 668464 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.170941615264981 0.441368952322736 no 1472 0.432134836986124 443 6312947 SGTC_2118 5526350 200 µM 0.170602606723426 0.441494753594334 no 1473 0.432268124054172 463 743594 SGTC_3287 9117173 37.0625 µM 0.170193475589075 0.441646584226598 no 1474 0.432428991296071 470 2789709 SGTC_3156 9099931 49.47 µM 0.16912250078586 0.442044068935706 no 1475 0.432850143394625 443 18111053 SGTC_724 3910-0327 137 µM 0.167913183259064 0.44249296870379 no 1476 0.433325789322329 484 2885483 SGTC_3259 9138485 49.47 µM 0.166723515615323 0.442934646476293 no 1477 0.433793800860848 429 17646153 SGTC_3301 9125354 19.7965 µM 0.166048733785813 0.443185198536144 no 1478 0.434059299230552 445 41905162 SGTC_3293 9120939 62.045 µM 0.16491877392225 0.44360481278067 no 1479 0.434503957641149 475 934087 SGTC_1696 st025591 34.7925 µM 0.163938786574164 0.443968785472898 no 1480 0.434889666439925 447 2787147 SGTC_1270 0831-1170 17.3 µM 0.163230519978035 0.444231869025364 no 1481 0.435168468494464 484 6764716 SGTC_516 3992-2719 87.3 µM 0.163150641231333 0.444261541296027 no 1482 0.435199913988607 434 5350887 YDR037W KRS1 SGTC_1874 staurosporine 7.6 µM 0.162837175338677 0.444377986360444 no 1483 0.435323318604232 489 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2822 7994718 71.43 µM 0.16270947932514 0.444425423745088 no 1484 0.435373591517741 501 1018011 SGTC_2825 7998094 58.44 µM 0.162469907881875 0.444514423523431 no 1485 0.43546791172318 484 2987815 SGTC_527 4476-4215 268 µM 0.160465503618865 0.445259160427021 no 1486 0.436257196795253 456 4418754 SGTC_3322 9139058 2.11 µM 0.159701458137426 0.4455430927256 no 1487 0.436558126109489 442 4908926 YPR165W RHO1 SGTC_496 calpeptin 138 µM 0.159544722896045 0.445601341665253 no 1488 0.436619862880721 445 73364 A calpain inhibitor. SGTC_2927 9011802 47.9 µM 0.159454519332965 0.44563486536618 no 1489 0.436655394050393 450 43912568 SGTC_2782 7736369 71.43 µM 0.158205692907031 0.446099025269903 no 1490 0.437147358979765 466 2950836 YOL077C BRX1 SGTC_2610 ononetin 44.17 µM 0.157594656807833 0.446326160212893 no 1491 0.437388107103829 463 259632 SGTC_1868 st057644 42.7 µM 0.157310747307316 0.446431701330404 no 1492 0.43749997529504 447 688665 SGTC_642 0335-0876 158 µM 0.155751961247982 0.447011235171842 no 1493 0.438114268880337 487 6812350 SGTC_1656 st012921 11 µM 0.155152100756665 0.447234284745243 no 1494 0.438350704488019 483 6732821 SGTC_2971 9092186 9.93 µM 0.154702072254674 0.447401632390442 no 1495 0.438528098120561 416 25236400 SGTC_1387 3342-1166 1.8 µM 0.154494851324562 0.447478692737375 no 1496 0.438609785265287 461 3418228 SGTC_1938 st074717 56.4 µM 0.154031737474054 0.447650920504932 no 1497 0.438792355655299 475 17250979 SGTC_2617 dihydrotanshinone i 20.83 µM 0.153743153992942 0.447758247032277 no 1498 0.438906128650968 474 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_2305 7443522 69.23 µM 0.153105491547806 0.447995412397782 no 1499 0.439157542655133 465 5415886 SGTC_3076 9116187 49.47 µM 0.15267997511646 0.448153684786112 no 1500 0.439325326569802 482 27241210 SGTC_1504 k297-0033 30 µM 0.152635555825877 0.44817020717942 no 1501 0.439342842015758 442 4388117 SGTC_2932 9016711 44.54 µM 0.152050098601425 0.448387984796915 no 1502 0.439573711005708 465 7117328 SGTC_199 4063-0024 41.6 µM 0.151930261745843 0.448432563474622 no 1503 0.439620969964485 487 306215 SGTC_1322 1348-1070 12 µM 0.151529483537481 0.448581655579741 no 1504 0.439779027428163 483 6758089 SGTC_2840 9008771 71.43 µM 0.151074898949827 0.448750772797478 no 1505 0.439958316474879 487 2992978 SGTC_2802 7925815 54.55 µM 0.150596916682053 0.448928604600392 no 1506 0.440146846891837 454 1262923 SGTC_415 dibenzyl ketone 100 µM 0.150091681171124 0.449116587040963 no 1507 0.440346141551448 492 7593 SGTC_933 2914-0560 114 µM 0.149833905148014 0.449212501895598 no 1508 0.440447829431744 449 463887 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.149802519434393 0.449224180283666 no 1509 0.44046021078446 464 23665772 A membrane-active detergent. SGTC_2879 9041815 71.43 µM 0.148482558595914 0.449715367488354 no 1510 0.440980974800387 493 4942971 SGTC_1137 ixabepilone 100 µM 0.148471080301415 0.449719639159698 no 1511 0.440985503779718 479 154225 A novel microtubule stabilizer. SGTC_2441 5730946 39.09 µM 0.148362537518127 0.449760033871875 no 1512 0.441028331780091 453 1774275 SGTC_3244 9134489 49.47 µM 0.146351830146224 0.450508421875054 no 1513 0.441821825874631 491 16584271 SGTC_2606 farnesol 9.78 µM 0.145304443411933 0.450898330523572 no 1514 0.442235253312266 495 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2644 guaiazulene 100 µM 0.144175559794383 0.451318630911046 no 1515 0.44268091987493 486 3515 A coloring agent. SGTC_380 3970-0968 6 µM 0.143366843215316 0.451619761868001 no 1516 0.44300023385482 491 2891601 SGTC_1454 4239-0054 42.6 µM 0.13977001360939 0.452959399993801 no 1517 0.44442085317999 511 1340767 SGTC_2523 spermine 47.74 µM 0.138126048167751 0.453571873695282 no 1518 0.445070399813881 480 1103 A DNA binding polyamine. SGTC_986 1493-0483 84 µM 0.137258604855019 0.453895091892621 no 1519 0.445413194611949 490 40079 SGTC_88 0180-0332 8.668 µM 0.137035897602148 0.453978079814364 no 1520 0.44550121028682 470 3101745 SGTC_1974 st069448 26.9 µM 0.135871384342511 0.454412047739408 no 1521 0.445961478820987 481 6323587 YNR016C ACC1 SGTC_744 1594-0068 283 µM 0.13465016710703 0.454867205443691 no 1522 0.446444237568535 456 668392 SGTC_2134 5324836 1.464 µM 0.134153431424563 0.455052359904989 no 1523 0.446640624645362 512 699272 SGTC_2933 9026794 32.47 µM 0.133544063109537 0.455279510659564 no 1524 0.446881559498858 494 17586027 SGTC_2034 5197015 53.07 µM 0.132387709060225 0.455710598308315 no 1525 0.447338817928219 506 780676 SGTC_1388 3346-4487 254 µM 0.13053449753724 0.456401582283257 no 1526 0.448071781268031 489 3345614 SGTC_2729 fluphenazine 10.66 µM 0.129766906319407 0.456687823231538 no 1527 0.448375423203409 494 3372 An atypical antipsychotic. SGTC_1655 st012546 55.1 µM 0.128515600642769 0.457154493315331 no 1528 0.448870476535033 498 720985 YLR208W SEC13 SGTC_606 k015-0008 38.6 µM 0.128123108918278 0.45730088393791 no 1529 0.449025774245124 484 1970475 SGTC_632 0781-2353 4.65 µM 0.12749801615834 0.457534041490859 no 1530 0.44927312162268 486 6811515 YHR007C ERG11 SGTC_1122 capsaicin 818.572 nM 0.12731713785005 0.457601511237819 no 1531 0.449344698322205 499 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1292 0kpi-0043 232 µM 0.126490362135793 0.457909923879726 no 1532 0.449671888835951 496 3333905 SGTC_2040 5100729 123 µM 0.126464439226981 0.457919594328749 no 1533 0.449682148194192 498 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_261 5-fluorouridine 15.376 µM 0.126350364251175 0.457962149889069 no 1534 0.449727295380781 476 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2600 tangeritin 87.95 µM 0.125040876675175 0.458450687369124 no 1535 0.450245594682678 487 68077 A bioactive flavone. SGTC_1023 4482-3888 16 µM 0.123558844277582 0.45900367274303 no 1536 0.45083229010611 496 3303168 SGTC_1296 1068-0102 11.9 µM 0.122626718851416 0.45935151403243 no 1537 0.45120134776824 497 767053 SGTC_3010 9080089 71.4286 µM 0.121876146211835 0.45963162789072 no 1538 0.45149855367042 469 17027233 SGTC_749 1000-0129 128 µM 0.120031384545512 0.460320178181775 no 1539 0.452229143205393 485 708470 SGTC_2710 st078562 53.7235 µM 0.119948036768061 0.460351290248678 no 1540 0.452262155651488 501 17250908 SGTC_1088 bifonazole 369 nM 0.119844478991157 0.460389946644389 no 1541 0.452303173348087 497 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1539 benzyladenosine 56 µM 0.11971361955596 0.460438794830424 no 1542 0.452355005553859 460 92208 A nucleotide analog. SGTC_66 0109-0187 42.4 µM 0.119553133565134 0.460498703053153 no 1543 0.452418573671362 420 759417 SGTC_2212 7123476 200 µM 0.118942630223062 0.460726607576391 no 1544 0.452660403717481 498 1085715 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.11741866856205 0.461295567649375 no 1545 0.453264145514131 495 688664 SGTC_2162 5663267 200 µM 0.116565434429344 0.461614151119109 no 1546 0.453602215136677 496 6456493 SGTC_2741 miltefosine 3.04 µM 0.116146151098548 0.461770713598015 no 1547 0.453768356501764 508 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1170 0310-0127 64.8 µM 0.116059717637355 0.461802989019168 no 1548 0.45380260683876 490 774975 SGTC_1662 st014054 52 µM 0.11590710982084 0.461859975451886 no 1549 0.453863080428076 493 2838777 SGTC_2215 7188065 200 µM 0.113904925537522 0.46260769823619 no 1550 0.454656580484257 492 940217 SGTC_672 1441-0018 53.7 µM 0.11375599367216 0.462663322679743 no 1551 0.454715612013849 478 251141 SGTC_1308 1187-1617 41.4 µM 0.112715854722556 0.463051823641767 no 1552 0.455127915553013 510 2882570 SGTC_2537 larixol 68.93 µM 0.111984777465235 0.463324908481799 no 1553 0.455417738233501 517 6708759 SGTC_3223 9129970 49.47 µM 0.111912816686067 0.463351789474555 no 1554 0.455446267100072 487 17248386 SGTC_3108 9121785 49.47 µM 0.111735983290294 0.463417846407496 no 1555 0.45551637371402 503 17140271 SGTC_848 0368-0089 85.6 µM 0.111036310631752 0.463679222238603 no 1556 0.45579377651492 511 762535 SGTC_2043 5101342 149 µM 0.110785491045434 0.46377292441801 no 1557 0.455893225495167 487 678451 SGTC_2526 patulin 37.61 µM 0.110546754807557 0.463862114318825 no 1558 0.455987886042293 478 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_37 0566-0070 1.56 µM 0.110342630909852 0.463938374773665 no 1559 0.456068824541818 510 1626686 SGTC_879 0831-1030 162 µM 0.109442404590816 0.464274714066386 no 1560 0.45642580086145 513 1549252 SGTC_816 0325-0417 81.3 µM 0.109191358836067 0.464368513433825 no 1561 0.456525356989511 514 68101 SGTC_600 1495-0418 41.6 µM 0.10864495301931 0.464572676363664 no 1562 0.456742052204269 487 5377768 SGTC_1853 st056710 91.2 µM 0.108015163450453 0.464808006956032 no 1563 0.456991831945789 510 269167 SGTC_210 3551-0445 56.827 µM 0.107606594238786 0.464960681736277 no 1564 0.457153882961244 494 2865180 YOR207C RET1 SGTC_432 NS 1619 61.3 µM 0.104379334602278 0.466166828643881 no 1565 0.458434160844716 466 4552 A K+/calcium channel activator. SGTC_1829 berberine 14.4 µM 0.103768435972647 0.466395179496752 no 1566 0.458676557826098 491 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1548 st061468 90.8 µM 0.103663376669849 0.466434451255715 no 1567 0.458718245602376 511 390799 SGTC_1358 1509-0022 2.48 µM 0.102468932486501 0.466880964104019 no 1568 0.459192235652179 470 3258434 SGTC_2343 7990716 14.84 µM 0.102205820378117 0.466979327555081 no 1569 0.459296653978927 504 6456862 SGTC_1984 st072354 53.1 µM 0.102126537432512 0.467008967575419 no 1570 0.459328118655761 491 5762938 SGTC_2831 7999036 19.48 µM 0.100977123102867 0.467438697912824 no 1571 0.459784310229099 513 2988270 SGTC_1677 st019204 53.9 µM 0.0994269165990717 0.468018332021835 no 1572 0.460399656145007 466 3945625 SGTC_2189 6047310 154.431 µM 0.0979239174771554 0.468580379685871 no 1573 0.460996353928645 522 711535 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.0969972338114633 0.468926945029146 no 1574 0.461364295595481 502 61125 An anti-inflammatory. SGTC_2409 alverine citrate 63.97 µM 0.095780461915888 0.469382034593986 no 1575 0.461847467569604 417 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_250 brefeldin a 552.239 µM 0.0951117472847184 0.469632160212424 no 1576 0.462113033697175 514 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.0946587682486374 0.469801599033153 no 1577 0.462292934517114 498 17037758 SGTC_990 3985-0011 41.3 µM 0.0945436739203366 0.469844651450392 no 1578 0.462338645509792 512 5399565 YGL099W LSG1 SGTC_2083 5306046 65.942 µM 0.0917005716405448 0.470908258695344 no 1579 0.463467971601804 498 539837 SGTC_886 0866-0150 153 µM 0.0903967342648791 0.471396095362596 no 1580 0.463985975874536 509 271463 SGTC_1612 st002233 45.4 µM 0.0903609511248559 0.471409484395208 no 1581 0.464000193097758 509 1035021 SGTC_2690 usnic acid 100 µM 0.0893179558477548 0.471799757679907 no 1582 0.464414612199548 503 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_363 0455-0021 3.06 µM 0.0865382365738856 0.472840018441761 no 1583 0.46551928083686 508 4597466 SGTC_1686 st019653 115.5 µM 0.0856688017105102 0.473165427428393 no 1584 0.46586485177618 522 97252 SGTC_947 3447-0010 211 µM 0.0838643789290372 0.473840837271357 no 1585 0.466582130625125 493 748350 SGTC_1568 digitonin 820 nM 0.0837076936344703 0.473899489403571 no 1586 0.466644419990831 508 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_634 1611-4317 11.2 µM 0.0815322831173466 0.474713870465651 no 1587 0.467509326058665 499 2843522 SGTC_349 k015-0014 24 µM 0.0813430653624236 0.474784710579645 no 1588 0.467584563117425 502 2196908 SGTC_2540 epiandrosterone 100 µM 0.0813049339532219 0.474798986468561 no 1589 0.467599725128093 516 441302 A steroid. SGTC_2705 st078069 42.8 µM 0.0811771976406186 0.474846809468885 no 1590 0.467650516652183 496 1530061 SGTC_541 4513-1321 94 µM 0.0809207997130887 0.474942802985149 no 1591 0.467752469215138 497 747515 SGTC_3091 9116372 49.47 µM 0.0804149877244934 0.475132179568978 no 1592 0.467953603513875 471 17169793 SGTC_2165 5727197 32.143 µM 0.0796862558954207 0.475405027461748 no 1593 0.468243395447947 515 1361712 SGTC_1118 chelidonine 707.474 nM 0.078514235990053 0.475843873054957 no 1594 0.468709503248746 516 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1769 st044406 64.4 µM 0.0781187581575042 0.475991960543899 no 1595 0.468866792969504 525 670903 SGTC_1590 st077108 57.8 µM 0.0776200639323958 0.4761787023484 no 1596 0.469065140910551 518 5489485 SGTC_3193 9111931 49.47 µM 0.0766695694340181 0.476534640431427 no 1597 0.469443206667919 500 17087244 SGTC_1222 0366-0074 1.18 µM 0.0754411035428137 0.476994700032425 no 1598 0.469931878236125 504 286520 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.0754038923463733 0.477008636080551 no 1599 0.469946681192053 494 75037 A free radical scavenger. SGTC_1583 clindamycin 39.6 µM 0.075335904069983 0.477034098594104 no 1600 0.469973727660496 504 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1181 1222-0449 220 µM 0.0744840857849359 0.477353123781204 no 1601 0.470312601846812 504 658318 SGTC_381 3461-2219 42.7 µM 0.0743350974024248 0.477408924792623 no 1602 0.470371875292253 513 2883159 SGTC_1278 0874-0585 172 µM 0.0728903071583525 0.47795006869867 no 1603 0.470946703596858 506 766306 SGTC_1183 1254-0324 198 µM 0.0722401528275273 0.478193596301073 no 1604 0.471205395647266 506 5799357 SGTC_3007 9078383 71.4286 µM 0.07005512251437 0.479012099876362 no 1605 0.472074892971501 497 6496995 SGTC_1315 1237-0019 3.69 µM 0.0699860410251832 0.479037978986312 no 1606 0.472102385020516 519 825140 SGTC_291 SEC14.278 35.5 µM 0.0698920987958082 0.479073171497443 no 1607 0.472139770999547 516 1068044 SGTC_1056 3448-1962 115 µM 0.0688219886549707 0.479474066160798 no 1608 0.47256565758397 514 715507 SGTC_72 0744-0168 198.391 µM 0.0685653948976054 0.47957019681433 no 1609 0.472667782443329 520 677577 SGTC_2309 7664088 163.95 µM 0.0669092308978714 0.480190692815397 no 1610 0.473326982157471 513 704922 SGTC_77 0828-0286 12.516 µM 0.0664956917860385 0.480345636327256 no 1611 0.473491593788441 466 745345 SGTC_295 k015-0027 31 µM 0.0657413353504446 0.480628283816631 no 1612 0.473791881362837 513 3887424 SGTC_602 3130-1533 38.1 µM 0.0650780734862908 0.480876807412655 no 1613 0.474055919120559 526 720941 SGTC_486 niguldipine 82 µM 0.063786183146588 0.481360898757451 no 1614 0.474570240052754 502 1236 A calcium channel blocker. SGTC_2515 chrysin 20.77 µM 0.0630530913174225 0.48163561190431 no 1615 0.474862113816214 517 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1525 8-methoxypsoralen 92.5 µM 0.0625306836830852 0.481831380218847 no 1616 0.475070113848875 528 4114 Related to psoralen; DNA damaging agent. SGTC_1646 st011709 75.6 µM 0.0625295218938656 0.481831815595481 no 1617 0.475070576430481 526 5757843 SGTC_512 prima-1 270 µM 0.0614825592504882 0.482224170097604 no 1618 0.475487451914327 497 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.0609448027002733 0.482425703778865 no 1619 0.475701584171068 529 688667 SGTC_2125 5246583 200 µM 0.0603141953804692 0.482662040628573 no 1620 0.475952698125276 519 835267 SGTC_488 nitrendipine 139 µM 0.0591062514910497 0.483114766640865 no 1621 0.47643373968979 527 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.0589639401642596 0.483168105032986 no 1622 0.476490414848378 523 5024745 SGTC_2961 9083290 32.55 µM 0.0583260791923486 0.483407179491528 no 1623 0.476744447339986 529 17741490 SGTC_1836 st055642 81 µM 0.0572808102378874 0.483798965982029 no 1624 0.477160753231541 530 8571 SGTC_181 1447-1644 8.07 µM 0.0570584671965152 0.483882306371912 no 1625 0.477249310434256 515 534600 SGTC_2146 5545642 200 µM 0.05651630561742 0.484085526638271 no 1626 0.477465253140663 514 825326 SGTC_2370 9071495 200 µM 0.0556321989331797 0.484416928193523 no 1627 0.47781740658863 522 21791103 SGTC_967 1306-0166 352 µM 0.0555678325401451 0.484441055934259 no 1628 0.477843045404174 527 4437607 SGTC_2115 tiliquinol 12.7705 µM 0.0546674654217351 0.484778564456762 no 1629 0.478201694709265 521 71208 A bioactive hydroxyquinoline. SGTC_734 2023-0417 80 µM 0.0541072058399127 0.484988586957033 no 1630 0.478424875614743 530 3935732 SGTC_2460 5552655 174.22 µM 0.0533388411078485 0.485276627848897 no 1631 0.478730966752249 484 5401989 SGTC_3043 9092303 49.47 µM 0.0513752159423588 0.486012776799357 no 1632 0.479513266749719 523 25236084 SGTC_1602 st001878 87.6 µM 0.0500337653173688 0.48651570454741 no 1633 0.480047740587774 528 595405 YLR310C CDC25 SGTC_3265 9137266 49.47 µM 0.049932812680415 0.486553553916468 no 1634 0.480087964585166 524 17224265 SGTC_948 3448-0295 75.3 µM 0.0490948218767286 0.486867739785681 no 1635 0.480421864988487 514 678569 SGTC_939 1165-0479 45.3 µM 0.0490813878708633 0.486872776631976 no 1636 0.480427217928201 518 1377347 SGTC_3267 9137951 49.47 µM 0.0475274172732513 0.487455424739826 no 1637 0.481046439598584 527 16643986 SGTC_1854 st056233 32.9 µM 0.0466061427275981 0.487800861546749 no 1638 0.481413568081921 524 5393174 SGTC_2402 5553605 200 µM 0.0450267368805117 0.488393089348251 no 1639 0.482042998806528 520 6758546 SGTC_610 4215-0184 155 µM 0.04416249283998 0.488717164754395 no 1640 0.482387439622614 524 5605015 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.0436973592955145 0.488891584260931 no 1641 0.48257282209243 536 756377 SGTC_590 k048-0076 22.4 µM 0.0426737056458259 0.48927544955104 no 1642 0.482980820162335 517 6832814 SGTC_2145 5634607 200 µM 0.0425114220498077 0.489336306055518 no 1643 0.483045503251861 527 308662 SGTC_2023 5144124 124 µM 0.0424056547917719 0.489375969012651 no 1644 0.483087660267018 533 2830192 SGTC_3212 9128307 49.47 µM 0.0421340367182591 0.489477826875073 no 1645 0.483195923438054 499 27243542 SGTC_1726 st035556 14.5795 µM 0.0416241541281956 0.489669036730833 no 1646 0.483399158857806 471 5919439 SGTC_1054 3429-0080 167 µM 0.0412789371549944 0.489798497076434 no 1647 0.48353676223568 525 1162877 SGTC_1399 3562-5772 25 µM 0.0394423800119015 0.490487244920161 no 1648 0.484268845908892 529 23847490 SGTC_3245 9134821 49.47 µM 0.0386384217188994 0.490788755362629 no 1649 0.484589334525111 531 17014901 SGTC_1948 st076329 66.6 µM 0.0384856657376431 0.490846044411719 no 1650 0.48465023005095 532 24208413 SGTC_421 streptovitacin 30 mM 0.0375157679174488 0.49120979572863 no 1651 0.48503688400845 508 91467 include heat shock SGTC_136 0097-0015 404.482 µM 0.0371627739907804 0.491342184706405 no 1652 0.485177610073962 517 4861337 SGTC_192 3455-0609 60.9 µM 0.0361263829781729 0.491730884518072 no 1653 0.485590792740255 523 3769639 SGTC_1129 3453-1384 223 µM 0.0353664252504114 0.492015912673757 no 1654 0.485893778361706 519 1084452 SGTC_1495 4469-0029 237 µM 0.0347241089940144 0.492256821650022 no 1655 0.486149868160077 515 793680 SGTC_2685 mycophenolic acid 18.85 µM 0.033721822652809 0.492632747647477 no 1656 0.48654948845348 534 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_548 1436-0017 110 µM 0.0332161230080632 0.492822422140432 no 1657 0.486751120457897 534 9677137 SGTC_301 4119-0100 24.5 µM 0.0312048534445131 0.493576811526136 no 1658 0.487553084655891 531 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1824 st053723 68.6 µM 0.030263401128241 0.493929940640989 no 1659 0.487928492431526 527 675225 SGTC_1258 0671-0043 57.1 µM 0.0297577742916237 0.494119598066237 no 1660 0.488130117536814 528 4298767 SGTC_1888 azatryptophan 97.5 µM 0.0296014227818208 0.494178244798746 no 1661 0.488192465298164 498 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_3036 9090181 49.47 µM 0.0284006912591136 0.49462863777231 no 1662 0.488671286439918 535 25236586 SGTC_3116 9124943 49.47 µM 0.0260393555264572 0.495514391445413 no 1663 0.489612973956456 537 41905195 YPL160W CDC60 SGTC_1022 4477-0945 21.3 µM 0.025746956428976 0.495624074034813 no 1664 0.489729585220891 509 4648966 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.0256056972470238 0.495677062254638 no 1665 0.489785920907639 528 23847180 SGTC_1441 4106-0040 13 µM 0.0245337474202868 0.496079167476492 no 1666 0.49021343263079 533 2904180 SGTC_2264 7948757 110.76 µM 0.0236056481608361 0.496427315322776 no 1667 0.490583583413489 533 2971411 SGTC_639 0833-0042 114 µM 0.0233457328231667 0.496524815053903 no 1668 0.490687246062122 543 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2603 homopterocarpin 100 µM 0.0226022110902602 0.496803726881265 no 1669 0.490983790042161 535 101795 A weak amylase inhibitor. SGTC_454 lyso-paf C-16 6.67 µM 0.020705812577259 0.49751511563281 no 1670 0.491740166124439 533 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2426 5582046 32.21 µM 0.0206337066805641 0.49754216461346 no 1671 0.491768926070949 536 2251934 SGTC_625 k213-0058 121 µM 0.0192820354100038 0.498049217055602 no 1672 0.492308057465757 540 3655420 SGTC_1663 st014140 55.4 µM 0.0179966543969485 0.498531404969308 no 1673 0.492820761192172 541 4207120 SGTC_3312 9133330 71.43 µM 0.0179069591300296 0.498565052647776 no 1674 0.492856538661066 540 17617324 SGTC_856 0433-0016 11.3 µM 0.016374989161623 0.49913974692418 no 1675 0.493467616416134 531 3911780 SGTC_2465 5809242 33.21 µM 0.0154300093783796 0.499494242093199 no 1676 0.493844561126081 543 2731748 SGTC_3356 9151811 4.48 µM 0.0149725581811981 0.499665848294975 no 1677 0.494027036663913 541 1859254 YPR165W RHO1 SGTC_126 0417-1624 672.48 µM 0.0142927715774142 0.499920860514224 no 1678 0.494298203244638 540 41912 YDL195W SEC31 SGTC_1966 st070145 16.1 µM 0.013870847054435 0.499920860514224 no 1679 0.494466510086517 540 3748532 SGTC_1237 0330-0133 46.1 µM 0.0137699887148632 0.49988302494647 no 1680 0.494506742899989 539 X1237 YHR072W ERG7 SGTC_1103 duloxetine 36.1 µM 0.0126238400176866 0.499453063764407 no 1681 0.49496395023488 528 60835 A selective serotonin reuptake inhibitor. SGTC_1649 st011737 51.3 µM 0.0122537073734478 0.499314213943538 no 1682 0.495111600372296 544 1761035 SGTC_2505 galangin 7.89 µM 0.0121698680930777 0.499282762880806 no 1683 0.495145044912137 544 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2079 5212404 121 µM 0.0118170513452844 0.499150408961129 no 1684 0.49528578830649 537 758462 SGTC_624 k048-0052 28 µM 0.0112478506322895 0.498936882040552 no 1685 0.495512851433966 538 6835531 SGTC_2892 9047358 58.44 µM 0.0106210001481156 0.498701729046973 no 1686 0.495762913642126 537 6466771 SGTC_668 1682-0499 62.6 µM 0.0103654566825237 0.498605866103237 no 1687 0.495864855122321 540 682214 SGTC_997 3996-0078 137 µM 0.00937619138653106 0.49823476024668 no 1688 0.496259495633329 542 735687 SGTC_946 3434-1334 87.4 µM 0.00884947147611529 0.498037170936677 no 1689 0.496469617748254 543 4047976 SGTC_3289 9119912 71.43 µM 0.00793557895021453 0.497694342094574 no 1690 0.496834195264252 542 17014829 SGTC_775 4577-0580 57.3 µM 0.00724726155199839 0.497436134444159 no 1691 0.497108786258909 540 2006902 SGTC_1427 4048-4900 550 nM 0.00688383301462383 0.497299802374856 no 1692 0.497253769648602 543 24132586 SGTC_3190 9110366 49.47 µM 0.00665212974920001 0.497212884252224 no 1693 0.497346203760457 543 17123768 SGTC_771 0250-0039 27.3 µM 0.0045597990931446 0.496428001276809 no 1694 0.498180909655295 546 3005115 SGTC_1035 k081-0041 55.2 µM 0.00435839744619896 0.496352451411828 no 1695 0.498261256488674 547 731709 SGTC_2463 5473429 200 µM 0.00433503757154502 0.496343688654879 no 1696 0.498270575642299 540 5399405 SGTC_2377 9073351 62.6 µM 0.00426774861634806 0.496318447229666 no 1697 0.49829741980319 540 7337946 YHR072W ERG7 SGTC_479 n-linoleoylglycine 10 µM 0.00386961946273379 0.496169101371861 no 1698 0.498456249039928 546 6433346 An anti-infammatory. SGTC_1985 st071382 65.5 µM 0.00283170493801791 0.495779762365594 no 1699 0.498870314684344 543 6123237 SGTC_143 4032-1194 15.74 µM 0.00253016253375546 0.49566664953005 no 1700 0.498990612265967 547 1806963 SGTC_2369 9071472 200 µM 0.00164227070241634 0.495333590759924 no 1701 0.499344829075447 547 17296037 SGTC_579 4491-1009 110 µM 0.00148891732968047 0.495276066411584 no 1702 0.499406008144636 547 1271041 SGTC_604 1000-0114 314 µM 0.0010735681612581 0.495120265377362 no 1703 0.499571708351852 546 1572745 SGTC_2954 9074818 52.69 µM 0.000272012071278626 0.494819596940624 no 1704 0.499891482885326 548 16648742 SGTC_2281 7943571 200 µM 0.000238536471959544 0.494807040107884 no 1705 0.49990483771682 548 1244024 SGTC_2130 NSC 7 2.4545 µM 5.70378085238507e-05 0.494738959314813 no 1706 0.499977245206611 547 21448 SGTC_264 promethazine 12.5 mM -0.00012405642150846 0.494671030378867 no 1707 0.499950508648432 549 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_371 0195-0006 7.36 µM -0.00118024318820883 0.494274855005156 no 1708 0.499529151200381 546 3928593 SGTC_1736 st036774 51 µM -0.00258108993851321 0.493749406540677 no 1709 0.498970295237328 549 1272247 SGTC_1272 0839-0021 27 µM -0.00288952007901394 0.493633717834823 no 1710 0.498847249874527 552 5027250 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.00522266727376175 0.49275859837797 no 1711 0.497916466679862 551 521171 SGTC_336 4111-0029 111 µM -0.00528531322462231 0.492735101526336 no 1712 0.497891474906316 554 3131175 SGTC_2546 rhodinyl acetate 100 µM -0.00569523121775331 0.492581352673794 no 1713 0.49772794375319 553 6708682 SGTC_520 3584-0023 682 µM -0.00573414903124671 0.492566755739936 no 1714 0.497712418045446 552 1340790 SGTC_3128 9127691 49.47 µM -0.00653954514503024 0.492264677471226 no 1715 0.497391117542159 552 41316314 SGTC_1369 1866-0067 208 µM -0.00783086688211584 0.491780353406371 no 1716 0.496875968037457 553 3531355 SGTC_2154 5570129 200 µM -0.00934880335869295 0.491211050600777 no 1717 0.496270421396743 550 673366 SGTC_115 0527-0192 112.043 µM -0.0101202657867794 0.490921720034919 no 1718 0.495962667005997 555 4233931 SGTC_3307 9126885 69.2785 µM -0.0103884239385675 0.490821150661868 no 1719 0.495855693006126 554 24824909 SGTC_497 capsazepine 133 µM -0.0106631988134577 0.490718100374616 no 1720 0.495746079763627 553 2733484 A calcium channel blocker. SGTC_1816 st051957 91.6 µM -0.0107686174227605 0.490678564835226 no 1721 0.495704026237841 554 674121 SGTC_953 1188-0045 9.7 µM -0.0113373952745424 0.490465255518071 no 1722 0.495477130567894 554 6144426 SGTC_750 4073-0104 132 µM -0.0123738989046571 0.490076541597775 no 1723 0.495063654523926 557 22330957 SGTC_713 1488-1073 324 µM -0.0141041553784067 0.489427674770248 no 1724 0.494373442636703 555 3312542 SGTC_1878 temozolomide 1 mM -0.0142222944802127 0.489383372198122 no 1725 0.49432631668095 551 5394 DNA alkylating agent. SGTC_2904 7225135 42.03 µM -0.0147242231213989 0.48919514868727 no 1726 0.494126097097957 556 4446116 SGTC_1450 4112-4260 37.6 µM -0.0164767741787277 0.488537960238796 no 1727 0.493427015546939 558 1633175 SGTC_1307 1187-1599 12.2 µM -0.0175159112425082 0.488148309212052 no 1728 0.493012519728912 558 1538471 SGTC_1266 0828-0227 32.9 µM -0.017618164778356 0.488109967238106 no 1729 0.492971732764091 553 3913820 SGTC_752 1896-0090 130 µM -0.0180511166534726 0.487947624641044 no 1730 0.492799037424245 558 772567 SGTC_1350 1495-0454 146 µM -0.018525857636719 0.487769614810522 no 1731 0.492609674846148 555 1069057 SGTC_3083 9117465 49.47 µM -0.0186432853974995 0.487725584236505 no 1732 0.492562836036947 557 16420915 SGTC_1148 3909-7663 27.7 µM -0.0186540506795618 0.48772154770658 no 1733 0.492558542057501 574 4084526 SGTC_106 0092-0003 11.579 µM -0.0192361795215176 0.487503275654133 no 1734 0.492326347926076 557 1072148 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.0216104331984392 0.486613077103897 no 1735 0.491379355493621 555 368090 SGTC_2885 9057732 51.95 µM -0.0239043113031413 0.48575307773519 no 1736 0.49046446767206 569 6471414 SGTC_1244 0416-0015 52.5 µM -0.0240288934119694 0.485706372434648 no 1737 0.490414780873548 560 96201 SGTC_3018 9082602 49.47 µM -0.0242046503889521 0.485640482228172 no 1738 0.490344684372126 558 17332089 SGTC_755 1995-0008 37.3 µM -0.0243042099842878 0.485603158123858 no 1739 0.490304977521183 559 689533 SGTC_1194 1488-0194 225 µM -0.0253783082364774 0.485200495278292 no 1740 0.48987660652739 560 1391452 SGTC_748 act1.228 77.9 µM -0.026736494177326 0.484691354002376 no 1741 0.489334952692045 562 4421505 YNR035C ARC35 SGTC_1092 toremifene 6.32 µM -0.0281274899364649 0.484169939231384 no 1742 0.488780234472505 565 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1005 4092-0690 4.4 µM -0.028628310501766 0.483982213219506 no 1743 0.48858051640939 564 1529343 SGTC_807 1315-0151 48 µM -0.0292879298561447 0.483734968991331 no 1744 0.488317476676821 558 4011080 SGTC_2462 5162487 171.77 µM -0.0294539660756173 0.483672734841837 no 1745 0.488251266373276 559 2259986 SGTC_1674 st016616 23.6 µM -0.0325320929612228 0.482519056556895 no 1746 0.487023861542911 563 625830 SGTC_521 r062-0005 13.8 µM -0.0332230168269082 0.482260118886442 no 1747 0.486748371739166 562 2832033 SGTC_2856 9022925 19.48 µM -0.0332881968748054 0.482235691731882 no 1748 0.486722383037112 561 4944862 SGTC_2070 5230947 200 µM -0.0333421630609946 0.482215467182737 no 1749 0.486700865588167 580 2835538 SGTC_786 4544-0069 423 µM -0.0339373945622049 0.481992399274483 no 1750 0.486463536901897 557 748821 YLR208W SEC13 SGTC_3033 9090887 49.47 µM -0.0356607891585059 0.481346574992532 no 1751 0.48577641818499 561 19325384 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.0375968072338124 0.480621130729567 no 1752 0.48500457679108 587 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1280 0880-0253 10.1 µM -0.0396500860923921 0.4798518179187 no 1753 0.484186047941016 574 6836607 SGTC_556 4058-0063 51.5 µM -0.0404126253159719 0.479566132286488 no 1754 0.483882082462998 573 6615692 SGTC_1626 st003712 1.76 µM -0.040500704729892 0.479533133971479 no 1755 0.483846972605409 576 24207035 SGTC_855 0428-0020 25 µM -0.0414191975325844 0.479189035690496 no 1756 0.48348085425548 568 6812414 SGTC_391 gliotoxin 8.33 µM -0.0414807573042152 0.479165973882323 no 1757 0.483456316547991 570 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2087 5276107 200 µM -0.0417710966860204 0.479057206533253 no 1758 0.483340588199058 561 144405 SGTC_1321 1326-2144 215 µM -0.0422032068667267 0.478895331697585 no 1759 0.483168353064912 565 3513030 SGTC_151 3013-0144 2.285 µM -0.0427853106382266 0.478677272562702 no 1760 0.482936336839794 558 906558 YHR107C CDC12 SGTC_1402 3909-7673 35.9 µM -0.0435331267864979 0.478397146075312 no 1761 0.48263827909532 566 5328014 SGTC_657 3534-0529 86.7 µM -0.0438659961339644 0.478272459064085 no 1762 0.482505610175586 574 1049549 SGTC_779 1360-0071 233 µM -0.0445710902694256 0.478008350223045 no 1763 0.482224593186829 563 7566 SGTC_1997 st073024 93.8 µM -0.0446513352390009 0.477978293277751 no 1764 0.482192611915452 568 686268 SGTC_42 0133-0086 60.653 µM -0.0455712732389308 0.477633725826845 no 1765 0.481825983005077 568 162923 Model of phenazepam hydroxylation. SGTC_2836 9010338 19.48 µM -0.0477203920460604 0.476828828059114 no 1766 0.480969541056585 572 2994051 SGTC_1919 st067113 52.3 µM -0.0477961218163776 0.476800467105331 no 1767 0.480939363684006 578 1268243 SGTC_1808 st050063 61.5 µM -0.0482548281755002 0.476628683152937 no 1768 0.48075657723981 565 4011993 SGTC_3167 9103034 49.47 µM -0.0484710522757614 0.476547709475971 no 1769 0.480670417126417 572 5127859 SGTC_370 0180-0345 38.7 µM -0.0499933367445639 0.475977657371603 no 1770 0.480063849095646 570 3989527 SGTC_741 4582-0002 126 µM -0.0507032307236065 0.475711839067091 no 1771 0.479781001108734 567 2912688 SGTC_2002 4023503 131 µM -0.051174431539142 0.475535404875992 no 1772 0.479593262908871 582 4736863 YCR052W RSC6 SGTC_681 1642-0006 26.6 µM -0.0516089682612046 0.475372703264351 no 1773 0.479420136612954 562 4446530 SGTC_2937 9044753 11.33 µM -0.0518499477635941 0.475282476171947 no 1774 0.479324128243113 563 6465530 YGL099W LSG1 SGTC_3217 9129673 49.47 µM -0.0519246019703317 0.475254524541111 no 1775 0.479294385588518 585 17248312 SGTC_1043 0916-0009 19.3 µM -0.0520728238028877 0.475199028472363 no 1776 0.479235333521119 562 3101130 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.0524924765259481 0.475041907968332 no 1777 0.479068144967162 569 688761 SGTC_1624 st003710 6.25 µM -0.0543031444572492 0.474364027812798 no 1778 0.478346822168677 571 24207033 SGTC_318 1488-0629 67.2 µM -0.0545064017547706 0.47428793668498 no 1779 0.478265854155522 576 3662576 SGTC_2811 7967822 32.47 µM -0.0555222446365692 0.47390766122697 no 1780 0.477861204312369 581 2232244 SGTC_2858 9025781 8.96 µM -0.0558494609400852 0.473785174564631 no 1781 0.477730866135134 589 4894980 YPL153C RAD53 SGTC_768 0384-0033 77.3 µM -0.0566059076601361 0.473502023870676 no 1782 0.477429564230353 579 3965305 YMR134W ERG29 SGTC_3044 9093193 49.47 µM -0.057274906856417 0.47325161740207 no 1783 0.477163104479909 585 25236277 SGTC_1550 gossypolone 36.6 µM -0.0578495152867969 0.473036549841006 no 1784 0.476934248346627 573 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_978 1416-0512 87.4 µM -0.0587304538797041 0.472706842648182 no 1785 0.476583401253882 575 6814003 SGTC_756 0508-1999 28.3 µM -0.0610719477370848 0.471830587753642 no 1786 0.475650954949437 583 6753853 SGTC_2673 kobusone 100 µM -0.0617062350597208 0.471593242336704 no 1787 0.475398387287249 573 6710676 An epoxy ketone and protein crosslinker. SGTC_2252 omeprazole 400 µM -0.062964615211268 0.471122396145828 no 1788 0.474897340678943 582 4594 A proton pump inhibitor. SGTC_303 1348-1668 34.2 µM -0.0641229665675073 0.470689013239748 no 1789 0.474436157399635 577 5380509 SGTC_3215 9129942 49.47 µM -0.0644966492026844 0.470549211860786 no 1790 0.47428738755372 569 17682944 SGTC_1720 st037298 9.481 µM -0.0648527613664928 0.470415987287885 no 1791 0.474145616167946 585 597396 SGTC_1579 chlormadinone acetate 49.4 µM -0.0651048387502846 0.470321685006879 no 1792 0.474045263921526 600 45114258 A steroidal progestin. SGTC_1607 st000305 50.6 µM -0.0666541749185024 0.469742114288127 no 1793 0.473428508126085 594 5457690 SGTC_1892 st058411 7.36 µM -0.067040400121195 0.469597646332962 no 1794 0.473274770440967 583 3934738 SGTC_2826 7992541 19.48 µM -0.0674787077685988 0.469433701732182 no 1795 0.473100306061762 580 2985066 SGTC_18 0111-0177 500 nM -0.0693631242537368 0.468728913933682 no 1796 0.472350290388752 583 721752 SGTC_2589 lobaric acid 100 µM -0.0694368317528155 0.468701348678859 no 1797 0.472320956078377 573 73157 A novel microtubule depolymerizer. SGTC_1833 st055984 71 µM -0.0694902658000035 0.468681365417575 no 1798 0.472299690345226 584 676288 SGTC_968 1309-0633 340 µM -0.0707356965131491 0.468215621783047 no 1799 0.471804055136022 575 3761976 SGTC_783 0848-0141 92.7 µM -0.0716833531172084 0.467861263428393 no 1800 0.471426952182669 577 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_977 1348-1378 135 µM -0.0728133821149154 0.467438743660001 no 1801 0.470977310918718 573 X977 SGTC_837 0091-0265 12.5 µM -0.0742413115795224 0.466904890922799 no 1802 0.470409187322471 584 759367 SGTC_2094 5332512 191.667 µM -0.0758654352999553 0.466297760449458 no 1803 0.469763078107169 583 755774 SGTC_2074 5212007 75.395 µM -0.0761458420742283 0.466192946594172 no 1804 0.469651534640652 583 758611 SGTC_2511 berberine 10.47 µM -0.0776252693569382 0.465639987257789 no 1805 0.469063070493438 585 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2567 aureobasidin a 60 nM -0.0794361607721791 0.464963228358159 no 1806 0.468342853683189 583 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_2545 solidagenone 89.61 µM -0.0795664602413284 0.464914537260542 no 1807 0.468291035731498 592 6708572 An anti ulcer agent SGTC_3210 9128157 49.47 µM -0.0802983454355973 0.46464105173615 no 1808 0.467999987058794 626 17590849 SGTC_688 0527-0193 473 µM -0.0817157378899021 0.464111458467063 no 1809 0.467436381594126 580 4007154 SGTC_985 1493-0307 8.71 µM -0.0819935391936847 0.464007668454917 no 1810 0.467325925567107 595 3278274 SGTC_2922 7999257 32.47 µM -0.084352895398386 0.463126283163328 no 1811 0.466387928886118 576 2988377 SGTC_2171 5739187 198.077 µM -0.0854696955152319 0.462709142706137 no 1812 0.465943993383375 579 2262761 SGTC_2669 eugenol 100 µM -0.0861023507029198 0.46247285531347 no 1813 0.465692527487894 598 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1356 1502-0781 85.8 µM -0.0864213284650305 0.462353726834446 no 1814 0.465565746347078 591 567702 SGTC_179 1273-0063 6.77 µM -0.0874264502116417 0.461978366609808 no 1815 0.465166272820025 608 3108139 SGTC_847 0342-0274 5.54 µM -0.0880211240053519 0.46175630307783 no 1816 0.464929943387994 600 18097 SGTC_194 1486-1323 56.904 µM -0.0888227532584535 0.461456976963436 no 1817 0.464611387337046 577 5178754 SGTC_3095 9117207 49.47 µM -0.0901621698416454 0.460956891367134 no 1818 0.464079172969463 579 17015229 SGTC_3348 9149464 3.537 µM -0.0902772024979882 0.46091394555445 no 1819 0.464033467968297 586 1951442 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.0905049503053226 0.46082892048205 no 1820 0.463942980162425 586 88881 An O-methylated flavonoid and antioxidant. SGTC_2783 7738165 71.43 µM -0.0910067634909081 0.46064158492701 no 1821 0.463743608436089 591 17201110 SGTC_3104 9120930 49.47 µM -0.092490799834191 0.460087619724074 no 1822 0.463154050279124 574 17014836 SGTC_156 3474-0145 5.642 µM -0.0937074495051221 0.459633523097674 no 1823 0.462670776235499 586 2265471 SGTC_1846 st056244 14.8 µM -0.0939292340122589 0.459550750943316 no 1824 0.462582685554834 607 5393182 SGTC_2653 dihydrofissinolide 100 µM -0.0941373542184464 0.45947308003461 no 1825 0.46250002387245 582 6857746 SGTC_2219 9098279 200 µM -0.094656988653745 0.459279158104137 no 1826 0.462293641299231 579 902349 SGTC_2168 5727979 200 µM -0.0947720614468035 0.459236215495622 no 1827 0.462247939349675 583 695210 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.0952457480448244 0.459059451200418 no 1828 0.462059816721269 579 97141 SGTC_1291 0993-0025 5.79 µM -0.095652556335355 0.45890765015428 no 1829 0.461898261302597 602 4353356 SGTC_1339 1486-1321 22.7 µM -0.0959400432617821 0.458800377643392 no 1830 0.461784095661744 605 3469382 SGTC_2514 salinomycin 42.74 µM -0.0962761401512981 0.458674970676346 no 1831 0.461650630222864 612 23682228 A polyether potassium ionophore. SGTC_84 0443-0269 128.823 µM -0.0973659082884448 0.458268376648219 no 1832 0.461217908652421 587 6150058 SGTC_2689 tacrolimus 100 µM -0.097532271771052 0.458206310029301 no 1833 0.461151853611231 586 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_171 k064-0041 9.68 µM -0.0983855551205663 0.457887984507512 no 1834 0.460813072186478 583 53325 SGTC_1474 0330-0125 5.35 µM -0.098585251917726 0.457813489598574 no 1835 0.460733790118051 587 X1474 SGTC_984 1492-0255 2.91 µM -0.0987896794592466 0.457737231467482 no 1836 0.460652631503061 594 1585198 SGTC_3225 9130819 49.47 µM -0.0991410774555016 0.457606152207304 no 1837 0.460513128816135 610 4547121 SGTC_2405 ticlatone 3.52 µM -0.100590757777911 0.457065438145049 no 1838 0.459937666858308 620 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1166 k206-0078 225 µM -0.101057071072109 0.456891525503348 no 1839 0.459752577923114 594 5404595 SGTC_1096 rimcazole 32.2 µM -0.101371944720709 0.456774097301877 no 1840 0.459627603298051 620 18528119 A dopamine reuptake inhibitor. SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.10154075144026 0.456711144494036 no 1841 0.459560604869847 585 5106787 A p450 inhibitor. SGTC_3118 9124250 49.47 µM -0.101944884340722 0.45656043630366 no 1842 0.459400211486284 590 1504786 SGTC_410 α-linolenic acid 100 µM -0.10203633333789 0.456526334247588 no 1843 0.459363917871187 579 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_836 0330-0104 1.35 µM -0.103360763184391 0.456032479881919 no 1844 0.458838325874602 589 46494820 SGTC_1840 st055363 71 µM -0.103508686702116 0.455977326255396 no 1845 0.458779627768471 610 676033 SGTC_2047 4141938 200 µM -0.103544100099767 0.45596412241379 no 1846 0.458765575373765 594 3807862 SGTC_1946 st076057 65.1 µM -0.104980861909705 0.455428468718648 no 1847 0.4581954973892 593 953009 SGTC_1142 3253-1408 9.78 µM -0.109474532359958 0.453753665373107 no 1848 0.456413060288431 593 256655 SGTC_1259 0671-0132 43 µM -0.109780360257942 0.453639712016609 no 1849 0.456291783566415 609 X1259 SGTC_1989 st071868 50.2 µM -0.111534823950467 0.452986062086699 no 1850 0.455596126172054 591 16414057 SGTC_2920 7982904 15.77 µM -0.113033918059961 0.452427654497529 no 1851 0.455001832400506 606 6456808 SGTC_1442 4112-3290 3 µM -0.11343737452825 0.45227738432164 no 1852 0.454841905170244 596 704353 SGTC_270 tamoxifen 5.46 µM -0.113632024089364 0.452204888178084 no 1853 0.454764750105816 586 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2214 7179297 48.276 µM -0.114156151293894 0.45200968785263 no 1854 0.454557005403009 594 769744 SGTC_560 2332-1943 155 µM -0.114926524390854 0.451722799412339 no 1855 0.454251680482607 598 21177716 SGTC_3134 9127454 49.47 µM -0.118150579683094 0.450522430179697 no 1856 0.452974173642705 596 24262820 SGTC_1240 0356-0016 42.1 µM -0.119663481226945 0.449959307149312 no 1857 0.452374865095084 603 4305613 SGTC_2720 fluspirilene 36.88 µM -0.120775518256248 0.449545455651197 no 1858 0.451934420867413 613 3396 An atypical antipsychotic. SGTC_739 1486-1183 203 µM -0.121086885396634 0.449429588247119 no 1859 0.451811108338697 621 4346692 SGTC_2951 9072950 58.06 µM -0.121470363397554 0.449286892536969 no 1860 0.451659243719075 586 16488155 SGTC_2529 gangaleoidin 93.61 µM -0.122196882105685 0.449016566205506 no 1861 0.451371547835321 587 4565183 SGTC_3165 9101544 49.47 µM -0.122551481404059 0.448884633898212 no 1862 0.451231138475263 610 5002184 SGTC_224 benfluorex 43.875 µM -0.126024135005761 0.447592898429282 no 1863 0.449856409956299 599 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_510 ag-490 170 µM -0.126536515311364 0.447402353191417 no 1864 0.449653623146439 605 5328779 SGTC_2179 6298986 200 µM -0.128358418812447 0.44672491789267 no 1865 0.448932667934825 604 738374 SGTC_3320 9137005 35.139 µM -0.128662140501605 0.446612000632937 no 1866 0.448812496925874 585 4908713 SGTC_24 0417-1663 219 µM -0.128818523888683 0.446553862305594 no 1867 0.44875062385572 636 4329390 SGTC_1886 st057356 49.9 µM -0.129513985197007 0.446295326029444 no 1868 0.448475479782063 601 24207747 SGTC_894 0960-0238 55.9 µM -0.130451988887319 0.445946661312421 no 1869 0.448104418390241 598 6741907 YDL195W SEC31 SGTC_662 k832-1615 104 µM -0.130888879147148 0.445784279379806 no 1870 0.447931606075498 598 5878478 SGTC_2193 5925765 200 µM -0.134582711597089 0.444411734038663 no 1871 0.446470905691143 613 877370 SGTC_567 1080-0542 68.4 µM -0.135256155333654 0.444161568775405 no 1872 0.446204674711913 601 5950415 SGTC_2135 5326629 150.42 µM -0.135702565897432 0.443995752156053 no 1873 0.446028209597422 610 5020077 SGTC_2794 7785382 27.27 µM -0.139498147696855 0.442586304188505 no 1874 0.444528259776657 617 2205081 SGTC_3230 9131665 49.47 µM -0.141880868971061 0.441701876552462 no 1875 0.443587052891562 613 15943720 SGTC_994 3910-0338 138 µM -0.142395314048099 0.441510960843177 no 1876 0.44338388175993 608 3479481 SGTC_1340 1486-1359 257 µM -0.143056968269488 0.441265434332834 no 1877 0.443122594825647 625 4309068 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.143158462781913 0.441227773764715 no 1878 0.443082516876379 606 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2092 5303694 80.6725 µM -0.143723226207783 0.441018222283457 no 1879 0.442859514875487 638 1963699 SGTC_720 r052-1644 49.9 µM -0.144592532493796 0.440695704614595 no 1880 0.442516296739483 630 1422863 YOR257W CDC31 SGTC_1610 st001799 48.1 µM -0.144796731798741 0.440619951186414 no 1881 0.442435681339444 608 621897 SGTC_2385 9074692 200 µM -0.145765545750452 0.440260572285652 no 1882 0.44205323792087 600 17046906 SGTC_1704 st028805 70.8 µM -0.145765996514784 0.44026040508728 no 1883 0.44205305999228 611 2876101 SGTC_2698 st077697 67.5 µM -0.145832991351196 0.440235555352153 no 1884 0.442026615490398 606 3154499 SGTC_1834 st055981 52.8 µM -0.146897486793249 0.439840744187192 no 1885 0.441606467825935 631 471719 YDL150W RPC53 SGTC_2428 5615643 7.78 µM -0.149106749127215 0.439021541286152 no 1886 0.440734700197121 611 2253075 SGTC_2886 9058944 51.95 µM -0.149233243028608 0.438974644735089 no 1887 0.440684794771889 599 4949929 SGTC_218 alverine citrate 93.75 µM -0.149581104554804 0.438845682416175 no 1888 0.440547558411522 613 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1485 3909-9022 254 µM -0.150608968106781 0.438464661680124 no 1889 0.44014209328468 616 714516 SGTC_1009 4106-0057 9.87 µM -0.150706286522376 0.438428589477488 no 1890 0.440103706976297 611 2928005 SGTC_2999 9069765 71.4286 µM -0.153249142668035 0.437486232439793 no 1891 0.439100902544399 618 2097066 SGTC_3016 9080866 49.47 µM -0.153346077235424 0.437450316439904 no 1892 0.439062682978695 632 17066299 SGTC_1811 st050069 61.5 µM -0.153696491790813 0.437320485848781 no 1893 0.438924525530056 613 3877702 SGTC_1969 st069479 40.1 µM -0.153891299391828 0.437248311439715 no 1894 0.438847722231121 613 3895485 SGTC_2050 5263056 171 µM -0.154900972206809 0.436874270540015 no 1895 0.438449693594603 636 763468 YGL055W OLE1 SGTC_870 0573-2213 57.6 µM -0.155869124980458 0.436515664039714 no 1896 0.438068091254896 601 3916321 SGTC_1522 st012842 45.6 µM -0.157891370372997 0.435766787307628 no 1897 0.437271199106197 613 3491067 YOR116C RPO31 SGTC_1708 st033234 31.827 µM -0.15842611684241 0.43556879869182 no 1898 0.437060517692087 614 674664 SGTC_175 3793-3120 23.7 µM -0.160186406595366 0.434917169909572 no 1899 0.436367118543552 657 5322297 SGTC_1529 apigenin 74 µM -0.160973966461095 0.434625686003989 no 1900 0.436056952483622 659 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_838 0109-0203 71.4 µM -0.16106694119557 0.434591277452267 no 1901 0.436020338674886 613 759422 SGTC_2411 st077133 39.94 µM -0.162474195971947 0.43407053426023 no 1902 0.43546622345322 624 1403142 YNL221C POP1 SGTC_1082 camptothecin 424.86 nM -0.162685113949273 0.43399249561252 no 1903 0.435383184092766 592 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1241 0364-0022 50.8 µM -0.16532036035333 0.433017684818921 no 1904 0.43434591703433 638 4563895 SGTC_649 1123-0311 367 µM -0.165897331002768 0.432804310281231 no 1905 0.434118873970927 619 693629 YIL048W NEO1 SGTC_806 3966-4455 5.86 µM -0.166352796785975 0.432635884349489 no 1906 0.433939659493831 665 714982 SGTC_1214 0358-0031 63.7 µM -0.167555252521449 0.432191289134308 no 1907 0.433466588355218 685 4301366 SGTC_438 sphingosine 6.67 µM -0.168250967444765 0.431934095113688 no 1908 0.433192923088974 622 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_551 k048-0028 34.9 µM -0.168359688308207 0.431893905455825 no 1909 0.433150159721484 645 6836383 SGTC_3311 9131146 2.8755 µM -0.168378478446225 0.431886959581512 no 1910 0.43314276904293 632 4900406 YPR165W RHO1 SGTC_2796 7949634 45.45 µM -0.169359547500932 0.431524331495149 no 1911 0.432756920118522 617 2971588 SGTC_2995 9067767 71.4286 µM -0.170904699918567 0.430953320963038 no 1912 0.432149350518193 647 11673567 SGTC_1251 0490-5699 265 µM -0.171182979971755 0.430850497967415 no 1913 0.432039944985885 620 3883818 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.171476445289453 0.430742069175491 no 1914 0.43192457502771 616 688669 SGTC_2833 9001315 45.46 µM -0.172870712390893 0.43022699050299 no 1915 0.431376526576061 611 2989378 SGTC_2639 lactacystin 53 µM -0.174413092904516 0.429657333190309 no 1916 0.430770412686211 628 3870 A proteasome inhibitor. SGTC_795 0685-0265 78 µM -0.175279923458786 0.429337245282602 no 1917 0.43042984315627 623 302754 SGTC_3336 9143619 71.43 µM -0.175492405391621 0.429258790781007 no 1918 0.430346368900145 627 45595730 SGTC_2552 juarezic acid 87.02 µM -0.176633210384621 0.428837620290385 no 1919 0.429898253053839 624 1549512 SGTC_2150 5556613 200 µM -0.177144603942639 0.428648846654809 no 1920 0.429697403512035 617 743190 SGTC_3119 9125183 49.47 µM -0.17720699988903 0.428625815197845 no 1921 0.429672898782385 613 22695334 SGTC_325 2810-4341 181 µM -0.177275367635201 0.428600579722121 no 1922 0.429646049061805 622 774970 SGTC_1111 tnp00062 510.699 nM -0.180818960194404 0.427292992978724 no 1923 0.428254840168369 626 676306 SGTC_3241 9133421 49.47 µM -0.183610382233805 0.426263518781474 no 1924 0.427159558877157 627 17018221 SGTC_892 0929-0076 29 µM -0.184388739074267 0.425976550653577 no 1925 0.426854251639519 612 5751038 SGTC_2731 amoxapine 43.43 µM -0.185500979410528 0.425566552903336 no 1926 0.426418056069563 614 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1219 1469-0211 33.1 µM -0.186105826485656 0.425343625902823 no 1927 0.426180886431503 651 6822282 SGTC_1805 st050013 60.3 µM -0.186667300239132 0.425136706259628 no 1928 0.425960748016391 640 4037144 SGTC_2753 fluvastatin 17.09 µM -0.187433214224856 0.424854477621491 no 1929 0.425660491423987 640 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2570 licareol 100 µM -0.187443225984707 0.424850788682105 no 1930 0.425656566859796 665 443158 SGTC_2911 7942208 15.64 µM -0.187582274444088 0.424799555479107 no 1931 0.425602061259654 628 1243384 SGTC_1906 st060206 94.7 µM -0.188359384367842 0.4245132482786 no 1932 0.425297468174581 626 5133468 SGTC_615 k087-0205 167 µM -0.19021227861766 0.423830755528364 no 1933 0.424571394913139 620 9642773 SGTC_1488 4013-0813 75.9 µM -0.190713086722737 0.423646327622577 no 1934 0.424375192578981 629 2910057 SGTC_698 k064-0052 127 µM -0.192526690759775 0.422978588901588 no 1935 0.423664831381822 625 5088751 SGTC_3121 9125696 49.47 µM -0.193157343271566 0.422746444915568 no 1936 0.423417872353541 637 1235365 SGTC_3222 9128301 49.47 µM -0.193404936586685 0.422655312832488 no 1937 0.423320924794241 636 4911358 SGTC_687 k029-0044 34.9 µM -0.194464289161206 0.422265441973292 no 1938 0.422906177532644 632 5829338 SGTC_1439 4092-1168 46 µM -0.194758648049658 0.422157123317041 no 1939 0.422790948194945 632 2886240 SGTC_1634 st006576 41 µM -0.195561823194745 0.421861599610464 no 1940 0.422476571954764 626 3915356 SGTC_1747 st037496 66.6 µM -0.198558934866747 0.42075921919155 no 1941 0.421303889572131 622 723305 SGTC_1715 st032160 10.2275 µM -0.198650886621447 0.420725407800764 no 1942 0.421267922511209 654 5289825 SGTC_3335 9143315 29.6265 µM -0.199363569833928 0.420463368371088 no 1943 0.420989177750359 627 4899691 SGTC_1603 st002045 67.8 µM -0.199603271432747 0.420375242779614 no 1944 0.420895434519465 652 5887985 SGTC_616 4092-0450 108 µM -0.201652300274971 0.419622086640913 no 1945 0.420094277650696 644 787165 SGTC_1430 4049-0248 69.1 µM -0.202716815746217 0.419230921494252 no 1946 0.419678189498636 641 22774488 SGTC_3132 9126706 49.47 µM -0.204732119228562 0.418490600198267 no 1947 0.418890712194696 643 850858 SGTC_1262 0737-0114 49.6 µM -0.204748521421595 0.418484576036791 no 1948 0.418884304386901 653 765919 SGTC_1827 berberine 7.24 µM -0.205252482056118 0.418299491805298 no 1949 0.418687433717486 656 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2963 9082507 9 µM -0.205800316667665 0.418098314968325 no 1950 0.418473446915095 663 16459611 SGTC_3056 9094900 49.47 µM -0.206125595910354 0.417978875459242 no 1951 0.41834640270783 646 25236784 SGTC_3283 9109332 35.8195 µM -0.207202704618297 0.417583425226312 no 1952 0.417925777584771 635 17027281 SGTC_2152 5568786 200 µM -0.207245665649814 0.417567654217172 no 1953 0.417909002680163 662 5399883 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.207878515709076 0.417335350123147 no 1954 0.417661912354441 650 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_82 0054-0107 293.755 µM -0.208243101963187 0.417201532337848 no 1955 0.417519577847266 627 3104697 SGTC_630 4356-0227 183 µM -0.209797636377579 0.4166310636369 no 1956 0.416912808954993 662 779312 SGTC_572 0960-0087 17.7 µM -0.211163903395396 0.416129828454788 no 1957 0.416379688277423 628 6796365 SGTC_2620 irigenin 100 µM -0.212178267657553 0.41575778214831 no 1958 0.415983980321491 617 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1921 5740136 50 µM -0.212214276518683 0.415744576282581 no 1959 0.415969934669396 676 1774243 SGTC_305 1682-2595 20.8 µM -0.214365072695902 0.414955967810747 no 1960 0.415131188259707 666 226033 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.214786092846196 0.414801637035157 no 1961 0.414967048080358 641 2333 A French combination drug. SGTC_2602 kawain 100 µM -0.21557187884351 0.414513631467893 no 1962 0.414660738916413 631 5369129 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.21597081226032 0.414367432332738 no 1963 0.414505249549159 634 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2596 sinensetin 100 µM -0.215973351070003 0.414366501960357 no 1964 0.414504260058704 641 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2684 capsaicin 100 µM -0.216429858428691 0.414199218056075 no 1965 0.414326347050786 661 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1010 4112-3296 15.2 µM -0.216875612518988 0.414035889629731 no 1966 0.414152641837157 634 704384 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.216959323409404 0.414005218841652 no 1967 0.414120022543148 633 279621 SGTC_2300 7976697 71.57 µM -0.217626246988781 0.413760883820684 no 1968 0.41386016622972 626 2236109 SGTC_1373 2887-0003 58.5 µM -0.218358505259411 0.41349265114677 no 1969 0.413574896718178 633 776948 SGTC_3278 9139605 49.47 µM -0.22036333570034 0.41275847094999 no 1970 0.412794098722009 680 7958859 SGTC_2680 butyl paraben 22.24 µM -0.221838288599422 0.412218529528147 no 1971 0.412219885995433 648 7184 An antifungal and steroid mimetic. SGTC_2177 5811945 192 µM -0.224062797631953 0.411404509828373 no 1972 0.411354219860077 628 5343475 SGTC_1223 0764-0573 147 µM -0.22466504171868 0.411184194698267 no 1973 0.411119931025257 642 1609797 SGTC_2310 7668677 200 µM -0.226076207659966 0.410668066643344 no 1974 0.410571074549309 663 2197143 SGTC_1107 amlodipine 47 µM -0.22632282192817 0.410577884353287 no 1975 0.410475174758273 663 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1102 cgs 12066b 26.1 µM -0.226389727500627 0.410553419034301 no 1976 0.410449158409379 629 6438352 A 5-HT1B full agonist. SGTC_517 1365-0151 113 µM -0.228265124047492 0.409867785891835 no 1977 0.409720067917174 665 768657 SGTC_2378 9074213 121.43 µM -0.22828390552648 0.409860920891509 no 1978 0.40971276789005 630 657714 SGTC_2612 dictamnine 15.46 µM -0.230017935691171 0.409227218036055 no 1979 0.40903891634365 662 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_714 4296-0578 26.1 µM -0.230891576113955 0.408908035103044 no 1980 0.40869951761231 632 1589775 SGTC_2133 5320837 200 µM -0.231032978511516 0.408856379668717 no 1981 0.408644590922233 674 2841355 SGTC_3288 9119690 36.221 µM -0.2312393247428 0.40878100256988 no 1982 0.408564440512017 669 17595618 YKL019W RAM2 SGTC_907 3448-6986 75.5 µM -0.234128623424549 0.407725913853721 no 1983 0.407442562560135 668 590582 SGTC_2123 5259487 200 µM -0.235341688942859 0.407283136171259 no 1984 0.40697177025406 644 2173474 SGTC_2695 st077686 51.995 µM -0.236363507973888 0.406910256721281 no 1985 0.406575305207062 650 2876092 SGTC_190 3970-0790 3.722 µM -0.23702144616004 0.406670208318695 no 1986 0.406320076311977 645 2832352 SGTC_1120 ficusin 1.78878 µM -0.237736978280964 0.406409186604472 no 1987 0.406042550625598 664 6199 A DNA cross-linker. SGTC_1791 st048313 56.1 µM -0.237744163651288 0.406406565636296 no 1988 0.406039763953084 622 1204976 SGTC_646 4092-0839 27.3 µM -0.238142490726299 0.406261276613831 no 1989 0.405885289858237 666 877796 SGTC_60 0986-0278 202 µM -0.238270356743707 0.406214640469301 no 1990 0.405835705605772 666 3110598 SGTC_443 clozapine 122 µM -0.238921489810799 0.405977175538326 no 1991 0.405583230799072 652 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2650 prasterone 100 µM -0.239136947635041 0.405898606773204 no 1992 0.405499696345826 650 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1507 4075-3230 155 µM -0.239444748132612 0.405786370940879 no 1993 0.40538036748164 635 659771 SGTC_2805 7950783 58.44 µM -0.239822881285884 0.405648499733999 no 1994 0.405233783917499 651 1178958 YDL195W SEC31 SGTC_832 4083-0019 164 µM -0.240833195599947 0.40528018627966 no 1995 0.404842200169933 647 1990758 SGTC_1981 st071826 47 µM -0.241336612957003 0.405096695087615 no 1996 0.404647118156262 635 11838600 SGTC_236 1509-0011 5.31 µM -0.241397748092528 0.405074413288968 no 1997 0.404623428958369 681 3107280 SGTC_2998 9066762 71.4286 µM -0.242641613790821 0.404621131004628 no 1998 0.404141520608234 673 4945196 SGTC_826 1683-5028 118 µM -0.242891875046636 0.404529947701843 no 1999 0.404044579950659 677 722377 SGTC_3316 9136639 10.545 µM -0.243055348837615 0.404470388424177 no 2000 0.403981260278634 683 4903665 SGTC_118 0083-0097 135.343 µM -0.244193711127553 0.404055704275309 no 2001 0.403540398728477 657 5207356 SGTC_603 3794-0023 45.9 µM -0.244524757320331 0.403935130533499 no 2002 0.403412215121491 680 3802260 SGTC_704 1310-0270 142 µM -0.245088672372624 0.403729762248165 no 2003 0.403193886816926 682 5718033 SGTC_1007 4101-0031 70 µM -0.246092232496904 0.403364348365699 no 2004 0.402805417894357 686 1146276 SGTC_3304 9125678 46.087 µM -0.246333084974251 0.40327666228487 no 2005 0.402712200368776 654 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_200 k038-0079 37.545 µM -0.246565325488132 0.403192116128053 no 2006 0.402622321182688 655 3436683 SGTC_2386 9075165 157.42 µM -0.247259478442002 0.402939439731693 no 2007 0.402353708389615 651 16452277 SGTC_893 0958-0369 48.9 µM -0.247891446465508 0.402709434314502 no 2008 0.402109199065527 692 6819948 SGTC_2711 st079103 59.1 µM -0.250488813079983 0.401764474415226 no 2009 0.401104677439751 665 54693780 SGTC_265 mycophenolic acid 32.932 µM -0.250779129035315 0.401658888798991 no 2010 0.400992439329291 678 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1943 st076331 65.2 µM -0.251504994497683 0.40139492870055 no 2011 0.400711850610567 658 24208415 SGTC_2795 7780010 54.55 µM -0.251594604329958 0.4013623453109 no 2012 0.400677214809333 652 953673 SGTC_476 mead acid 10 µM -0.252337957608024 0.401092078116158 no 2013 0.400389925616557 659 5312531 An omega 9 fatty acid. SGTC_164 4100-3994 89.624 µM -0.252570111355883 0.401007681719863 no 2014 0.400300214489988 663 4615967 SGTC_3192 9110362 49.47 µM -0.253071820144956 0.400825307970092 no 2015 0.400106357235516 641 16649480 SGTC_621 3584-0052 32.1 µM -0.253554979867375 0.400649697330661 no 2016 0.399919690492214 687 2273927 SGTC_127 0180-0333 59.125 µM -0.25358074919434 0.40064033169974 no 2017 0.399909735262195 653 771601 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.253939261229984 0.400510039641101 no 2018 0.399771241314826 669 616764 SGTC_2242 6630449 61.2675 µM -0.254231944510809 0.400403679571692 no 2019 0.399658186499981 673 691249 YDR170C SEC7 SGTC_2279 7948423 32.93 µM -0.256632674238021 0.399531542288899 no 2020 0.398731174571693 643 1247112 SGTC_1478 0453-0656 35.7 µM -0.257601908631099 0.399179580482953 no 2021 0.3983570782706 666 5258496 SGTC_2830 7992007 71.43 µM -0.258738831183796 0.398766829882636 no 2022 0.397918378264302 635 1952075 SGTC_1929 genistein trimethyl ether 50.5 µM -0.258820006835158 0.39873736403846 no 2023 0.397887060251691 643 136420 SGTC_385 1494-0393 12.4 µM -0.259561363967654 0.39846828650229 no 2024 0.397601071062776 680 3090647 SGTC_2116 5511452 16.8835 µM -0.259657312536513 0.398433465239647 no 2025 0.397564061539364 683 870744 SGTC_998 3996-0085 177 µM -0.259934943632797 0.398332713052587 no 2026 0.397456978169317 642 715391 SGTC_3176 9106582 49.47 µM -0.260307252872688 0.398197612853171 no 2027 0.397313389210169 645 17018027 SGTC_3065 9113888 49.47 µM -0.260566673805649 0.398103483751315 no 2028 0.397213346247093 700 16648368 SGTC_2806 7952793 58.44 µM -0.261616689152424 0.39772255353085 no 2029 0.396808487979239 653 2972490 SGTC_3219 9131112 49.47 µM -0.26194128809492 0.397604813490822 no 2030 0.396683353656725 655 17612988 YMR079W SEC14 SGTC_3195 9113082 49.47 µM -0.263145967201107 0.39716792829984 no 2031 0.396219037663264 645 17018038 SGTC_2699 st077704 54.6 µM -0.265464300435774 0.396327532189189 no 2032 0.395325903838199 663 645852 SGTC_401 neomycin 50 µM -0.265559315590276 0.396293099427653 no 2033 0.395289311107486 662 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2445 5742597 35.57 µM -0.266850927247625 0.395825109639597 no 2034 0.39479197061691 660 1774255 SGTC_3107 9121808 49.47 µM -0.267082033816348 0.395741388587823 no 2035 0.394703000116879 646 662681 SGTC_450 aminopyrene 156 nM -0.268895726684151 0.395084524467851 no 2036 0.39400496275818 668 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2832 7992762 51.95 µM -0.270744195250602 0.394415372313363 no 2037 0.393293891460746 640 2985177 SGTC_2335 9018011 154.17 µM -0.27144442922488 0.394161966373789 no 2038 0.393024617335692 670 6458208 SGTC_2211 7117706 200 µM -0.271630214196201 0.394094740625251 no 2039 0.392953182535825 654 822771 SGTC_470 aa-861 153 µM -0.272511637394761 0.39377584324457 no 2040 0.39261432220647 656 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_1444 4112-3581 28 µM -0.276065069074317 0.392490942256227 no 2041 0.391249044662673 664 2877249 SGTC_135 0933-0004 26.348 µM -0.276319807902012 0.392398874941347 no 2042 0.391151221718948 663 21230617 YGL099W LSG1 SGTC_3086 9117350 49.47 µM -0.276341617444966 0.392390992849703 no 2043 0.391142846897485 652 2679265 SGTC_1139 k015-0024 46.9 µM -0.276607729825754 0.392294821893025 no 2044 0.391040664334645 701 2766652 SGTC_2747 doxorubicin 7.63 µM -0.277485122229778 0.391977785689313 no 2045 0.390703814105582 643 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_172 1112-0046 2.638 µM -0.278813508020307 0.391497924458553 no 2046 0.390193973738515 698 2802135 YIL048W NEO1 SGTC_564 3555-0129 330 µM -0.280321303666627 0.390953453905648 no 2047 0.389615503882227 656 563260 SGTC_1123 mangostin 811.285 nM -0.280595847840507 0.390854337959373 no 2048 0.389510200542975 661 5281650 An antioxidant. SGTC_557 1315-0110 16.2 µM -0.280879531931385 0.390751929767993 no 2049 0.389401400046085 657 6833801 SGTC_2853 9015042 58.44 µM -0.281791453678333 0.390422783050135 no 2050 0.389051712235131 655 6457456 SGTC_3021 9087658 49.47 µM -0.283035489133101 0.389973890713385 no 2051 0.388574816207098 665 25237042 SGTC_2489 cantharidin 73.42 µM -0.285181344756214 0.389199934565419 no 2052 0.387752605959637 685 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2730 imipramine 71.33 µM -0.285671172348093 0.389023327559012 no 2053 0.387564993048114 678 3696 A tricyclic antidepressant. SGTC_1924 st058459 75.1 µM -0.285806828826299 0.388974420760227 no 2054 0.387513038779983 682 688683 SGTC_532 1548-0774 215 µM -0.28994755409296 0.387482458604111 no 2055 0.385928180277288 719 5932993 SGTC_3059 1327-0034 3 µM -0.290822884913023 0.387167276299988 no 2056 0.385593390921727 665 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1987 st072290 61.9 µM -0.290879631457805 0.387146846010977 no 2057 0.38557168990726 686 54697379 SGTC_1979 st071809 45.3 µM -0.290946913869914 0.387122622930197 no 2058 0.3855459602304 710 4976333 SGTC_1318 1280-3875 124 µM -0.291658814668773 0.386866350646365 no 2059 0.385273750906806 698 373245 SGTC_2010 4012422 159 µM -0.292948468374824 0.386402222721973 no 2060 0.384780770362003 682 952393 SGTC_2630 antimycin a 100 µM -0.294040528307791 0.386009332983254 no 2061 0.384363467206378 693 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1644 st010134 20.9 µM -0.294317731897995 0.385909622200223 no 2062 0.384257562149546 704 3818134 SGTC_1901 st060216 58.6 µM -0.294939970303282 0.385685829039646 no 2063 0.384019868732487 657 688792 SGTC_2239 6685329 187.64 µM -0.295862976679645 0.38535393230143 no 2064 0.383667363113714 673 805680 SGTC_1370 2001-0092 44.6 µM -0.296460456402164 0.38513913392251 no 2065 0.383439230769399 686 790957 SGTC_2106 5357045 167.29 µM -0.29671645103052 0.385047112739822 no 2066 0.383341498131065 679 668842 SGTC_2071 5230951 39.92 µM -0.298186402362527 0.384518841718307 no 2067 0.382780449672411 660 1799272 SGTC_2174 5790901 200 µM -0.300942809308339 0.383528822949753 no 2068 0.381729052728747 683 786020 SGTC_215 1287-0124 461.5 µM -0.301619629590543 0.383285845347809 no 2069 0.381471021133793 681 5560863 SGTC_1189 1431-2119 7.28 µM -0.30178223663386 0.383227476465906 no 2070 0.381409036516116 685 3107275 SGTC_1066 ketoconazole 628 nM -0.303867521353128 0.382479185016128 no 2071 0.380614411337949 713 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2216 7189485 200 µM -0.305136885244754 0.382023896244165 no 2072 0.380130949786119 678 731273 SGTC_1986 st071812 45 µM -0.305689019614393 0.381825910453729 no 2073 0.379920717223409 690 11838594 SGTC_2485 5633444 17.78 µM -0.305962193947555 0.381727966310009 no 2074 0.379816715550208 663 5724239 SGTC_1697 st025554 27.742 µM -0.307392995067614 0.381215089548962 no 2075 0.379272129695466 663 1269519 SGTC_1437 4092-1038 11.6 µM -0.307467837798311 0.381188267585477 no 2076 0.37924364993363 683 3977136 SGTC_2518 prenyletin 46.28 µM -0.309778327276299 0.380360521118054 no 2077 0.378364766885037 670 3873459 A coumarin with calcium channel inhibitory activity. SGTC_376 3970-0862 59.1 µM -0.310006806808506 0.380278696668434 no 2078 0.378277890052726 709 3135186 SGTC_1211 1056-0033 32.3 µM -0.310972913437819 0.379932768072489 no 2079 0.377910606686396 689 6741922 SGTC_2295 7971645 200 µM -0.311002246329642 0.379922266502926 no 2080 0.377899456967309 693 2978226 YKL099C UTP11 SGTC_2188 6126565 140.678 µM -0.313063034023088 0.379184698853941 no 2081 0.377116386501209 699 874518 SGTC_2052 5265182 7.135 µM -0.313101382496547 0.379170977874937 no 2082 0.377101819395493 697 1239884 SGTC_3228 9131799 49.47 µM -0.313727354176455 0.378947028452287 no 2083 0.376864061645235 681 17015818 SGTC_1705 st027868 56.3335 µM -0.313928092220741 0.378875220434474 no 2084 0.37678782682314 690 292948 SGTC_1145 3546-0597 10.2 µM -0.314484003800244 0.378676381558113 no 2085 0.376576731882732 675 875334 SGTC_690 glyoxal 20.3 µM -0.315185589123577 0.378425483827427 no 2086 0.3763103732895 687 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.315791382615426 0.378208883955472 no 2087 0.376080429676928 658 6708630 An antioxidant. SGTC_1492 4158-0558 28.5 µM -0.316576279473939 0.377928303067545 no 2088 0.375782568462417 688 3967268 SGTC_477 mead ethanolamide 10 µM -0.320919655772818 0.37637682289626 no 2089 0.374135639000749 675 16061185 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.320969578522644 0.37635900174057 no 2090 0.374116722481962 694 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1195 1502-0147 41.1 µM -0.32133612167476 0.376228163204702 no 2091 0.373977842775026 684 817940 SGTC_45 0kpi-0036 14.9 µM -0.322332144766009 0.375872702033785 no 2092 0.373600541779172 708 2795021 SGTC_764 1951-2361 146 µM -0.322669653255449 0.375752275723732 no 2093 0.373472718495781 692 5438930 SGTC_475 α-linolenic acid 10 µM -0.324393075201766 0.37513753092357 no 2094 0.37282023086575 700 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_667 1498-1044 59 µM -0.325511636819528 0.374738709418229 no 2095 0.372396938432231 701 6739982 SGTC_2095 5432005 200 µM -0.325643881428862 0.374691566642095 no 2096 0.372346903853739 719 783734 SGTC_995 3931-2021 34.6 µM -0.327009998506937 0.374204680689673 no 2097 0.371830161445759 696 730143 SGTC_891 0929-0073 133 µM -0.330258065137202 0.37304787204784 no 2098 0.37060248802839 717 5603632 SGTC_2642 cholecalciferol 100 µM -0.330852519345457 0.372836278905237 no 2099 0.370377944014576 712 9821465 A vitamin D precursor, similar to steriods. SGTC_285 1486-1325 46 µM -0.331746118769559 0.372518278639227 no 2100 0.370040486567018 678 22310230 SGTC_2468 5987765 72.9 µM -0.332494348478833 0.372252077108747 no 2101 0.369758003234181 661 26772094 SGTC_863 0466-0191 129 µM -0.332611312821418 0.372210469616177 no 2102 0.369713851381132 701 765160 YPR165W RHO1 SGTC_1173 0443-0020 122 µM -0.332727340451896 0.372169196812294 no 2103 0.369670054816451 701 5331295 SGTC_2224 6650123 117.647 µM -0.333023324326262 0.372063917470423 no 2104 0.369558338424573 695 2908370 SGTC_1187 1391-0724 117 µM -0.335971959406794 0.371015632491255 no 2105 0.368446005896049 686 6997986 SGTC_1378 2093-0007 380 nM -0.33631872046184 0.370892416324234 no 2106 0.368315267211291 709 3618014 SGTC_1703 st026983 48.3 µM -0.336544888953435 0.37081205798749 no 2107 0.368230003533651 705 1104023 SGTC_3157 9099274 49.47 µM -0.338004988723373 0.370293415946243 no 2108 0.367679714176481 689 17217662 SGTC_945 3381-0768 11.3 µM -0.339318038725901 0.369827208715968 no 2109 0.367185077478814 715 1126236 YIL048W NEO1 SGTC_1231 0242-0792 125 µM -0.340236073967389 0.36950136769413 no 2110 0.366839376910448 716 3707635 SGTC_1130 3454-2858 15.9 µM -0.340517614987027 0.369401458254156 no 2111 0.36673337984378 743 715628 YIL048W NEO1 SGTC_3328 9140624 29.0385 µM -0.340650798027607 0.369354199144152 no 2112 0.366683241448256 715 4904392 SGTC_1574 spiramycin 23.7 µM -0.341784484894415 0.368951997943311 no 2113 0.366256543238491 677 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2635 hydroquinidine 100 µM -0.342601202501945 0.368662337669146 no 2114 0.365949248649543 681 442912 An experimental heart treatment. SGTC_1494 4358-1428 177 µM -0.342781101850585 0.368598543880357 no 2115 0.365881572056625 722 1564571 SGTC_145 3737-0113 38.366 µM -0.343351491623434 0.36839630292517 no 2116 0.365667023914497 690 6849351 SGTC_2818 7996756 12.99 µM -0.344413569383875 0.36801982318626 no 2117 0.365267642755007 683 2241621 SGTC_3080 9117754 49.47 µM -0.345224945709534 0.367732296142079 no 2118 0.364962633153753 725 9550191 SGTC_1351 1496-0003 46.5 µM -0.346117002393648 0.367416263971501 no 2119 0.36462739308302 696 3891978 SGTC_1563 conessine 56.1 µM -0.347037922669047 0.367090100373929 no 2120 0.364281414478548 710 441082 An anti-amoebic, histamine inhibitor. SGTC_1956 st077085 54 µM -0.347205119487875 0.367030894326494 no 2121 0.364218612507136 704 24208685 SGTC_1976 st070609 63.5 µM -0.347423284869887 0.366953644561967 no 2122 0.364136671358029 677 682556 SGTC_3258 9138477 49.47 µM -0.347594052320048 0.366893181599217 no 2123 0.364072536820956 684 4970355 SGTC_1218 1348-1416 30.7 µM -0.349068580082421 0.366371238816962 no 2124 0.363518912082025 696 6787668 SGTC_3042 9091578 49.47 µM -0.349074056743543 0.366369300687644 no 2125 0.363516856350609 671 25236497 SGTC_449 xestospongin c 11.1929 µM -0.350365800954166 0.365912262119759 no 2126 0.363032094337055 721 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1470 k295-0292 231 µM -0.350929035956081 0.365713040602571 no 2127 0.362820793771669 684 5045612 SGTC_492 tmb-8 126 µM -0.351472139005363 0.365520974239145 no 2128 0.362617085361521 696 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2692 st077426 47.7 µM -0.352793008027405 0.365053994639092 no 2129 0.362121812979745 739 25238571 SGTC_1405 3909-7894 12 µM -0.353885266541797 0.364667989005939 no 2130 0.36171243453811 696 7104060 SGTC_1243 0416-0003 5.65 µM -0.354679523482596 0.364387383639375 no 2131 0.361414846398702 713 2141977 SGTC_522 1273-0010 11.6 µM -0.354899858291321 0.364309553776368 no 2132 0.361332307321027 684 5705015 SGTC_302 1094-0063 18.9 µM -0.355490693967802 0.364100877836747 no 2133 0.361111007697126 711 5440289 SGTC_1564 D-Arginine 115 µM -0.356327741027222 0.363805312024988 no 2134 0.360797568294422 744 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1822 st052468 42 µM -0.356478020738153 0.363752256025946 no 2135 0.360741304668161 688 2873678 SGTC_961 1252-1571 372 µM -0.357750831882449 0.363302997048676 no 2136 0.360264894450987 734 6813498 SGTC_917 harmaline 728.087 nM -0.358014064455505 0.363210108354725 no 2137 0.360166394161165 692 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1089 terbinafine 2.25 µM -0.358576364931812 0.363011712458652 no 2138 0.359956015282923 704 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1957 st077035 62.4 µM -0.358683498838622 0.362973916680176 no 2139 0.359915937053893 716 705593 SGTC_2834 9001755 58.44 µM -0.362408614504025 0.361660565190975 no 2140 0.358523351490601 723 2989575 SGTC_1456 k015-0012 13 µM -0.363076306744229 0.36142533079525 no 2141 0.358273941584196 709 2989616 SGTC_2791 5663188 71.43 µM -0.363584021588454 0.361246493023647 no 2142 0.358084330127599 738 54690634 SGTC_1748 st037455 53.6035 µM -0.364217315942489 0.361023463551098 no 2143 0.357847868739142 732 580690 SGTC_3340 9146634 11.102 µM -0.365269039008863 0.360653178989709 no 2144 0.357455293681802 721 4907387 SGTC_2977 9011197 71.43 µM -0.365663615239223 0.36051429255157 no 2145 0.357308049693163 741 2704722 SGTC_3088 9117578 49.47 µM -0.365930388269923 0.360420401840557 no 2146 0.357208510052288 703 678341 SGTC_3330 9141424 71.43 µM -0.372259178965402 0.358195464812948 no 2147 0.354849944257711 688 27261020 SGTC_3173 9105693 49.47 µM -0.372531330444333 0.358099895049127 no 2148 0.354748644788609 751 17096658 SGTC_1404 3909-7820 48.3 µM -0.37256466387579 0.358088190163735 no 2149 0.354736238216975 717 23741373 SGTC_1767 st044992 70.3 µM -0.373246023047435 0.357848963181214 no 2150 0.354482672801833 722 9600693 SGTC_983 1491-0821 12.2 µM -0.374008064400459 0.357581474601588 no 2151 0.354199158183577 690 46495113 SGTC_2076 5212012 200 µM -0.374020332595359 0.357577168842665 no 2152 0.35419459450826 706 604802 SGTC_987 1497-1013 404 µM -0.375692105642529 0.356990597691683 no 2153 0.353572903734207 734 1676435 SGTC_1949 st076024 69.1 µM -0.377700512053112 0.3562863596448 no 2154 0.352826543684548 706 2921930 SGTC_1828 st055811 49 µM -0.379797824559503 0.355551469943361 no 2155 0.352047748656919 740 5877589 SGTC_2027 5150920 200 µM -0.380249880038677 0.355393141766289 no 2156 0.351879968034157 719 786715 SGTC_1184 1269-1718 139 µM -0.380318237789879 0.355369202278655 no 2157 0.351854599529127 683 5403821 SGTC_1591 genipin 88.4 µM -0.380547623531064 0.355288873539128 no 2158 0.351769476134667 711 442424 A DNA cross-linking agent. SGTC_2285 7945142 200 µM -0.383270979426306 0.354335671971493 no 2159 0.350759427229742 751 2970608 SGTC_3040 9091894 49.47 µM -0.383418735930426 0.35428398175333 no 2160 0.350704656796854 695 25236966 SGTC_3238 9133470 49.47 µM -0.384130401045909 0.354035054863265 no 2161 0.350440900002133 710 3534688 SGTC_1367 1812-0510 76.9 µM -0.384456903307022 0.353920871461731 no 2162 0.350319916095773 706 1142582 YDR527W RBA50 SGTC_1383 3049-0032 20.7 µM -0.385495007893959 0.353557915936467 no 2163 0.349935352181492 733 712864 SGTC_296 1222-0039 74.9 µM -0.386517997210227 0.3532003754111 no 2164 0.349556538210812 717 5984176 SGTC_3139 9095020 49.47 µM -0.387065464549814 0.353009085686139 no 2165 0.349353872000646 697 25236292 SGTC_413 propylparaben 100 µM -0.38811805453185 0.352641406225386 no 2166 0.348964335802048 729 7175 A pharmaceutical preservative. SGTC_304 1310-0298 97 µM -0.389173379324655 0.352272909615579 no 2167 0.348573947246368 728 1550234 SGTC_758 0868-0029 16 µM -0.39064218386205 0.351760265635971 no 2168 0.348030870058532 683 762687 SGTC_1628 st004252 77.7 µM -0.391007113525957 0.351632939180066 no 2169 0.347895988892055 677 692968 SGTC_2003 4023581 200 µM -0.391454296754772 0.351476936585393 no 2170 0.347730732336925 711 16641307 SGTC_125 0133-0007 11.75 µM -0.391914600936594 0.351316382791361 no 2171 0.347560657145568 726 26541 SGTC_594 1487-1584 10.8 µM -0.39337061411681 0.350808701150759 no 2172 0.347022885206871 749 5013332 SGTC_2646 retinol 96.75 µM -0.395184781132565 0.350176511311531 no 2173 0.346353261718735 727 445354 A vitamin A analog and teratogen. SGTC_3248 9135562 49.47 µM -0.39667799282557 0.349656477243801 no 2174 0.345802465371711 711 17650701 SGTC_2033 5192550 145 µM -0.398541420359395 0.349007905364326 no 2175 0.345115566254098 686 182073 SGTC_2093 5331342 194.4 µM -0.399276038320842 0.348752340292433 no 2176 0.344844910442852 715 33839 SGTC_1723 st034307 2.5525 µM -0.399682374944193 0.348611009956063 no 2177 0.344695237642526 695 867466 SGTC_441 propafenone 146 µM -0.40036099472155 0.348375022061494 no 2178 0.344445324413733 693 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_340 k038-0059 454 µM -0.401381619551438 0.34802021350056 no 2179 0.344069589895688 702 23733424 SGTC_228 caffeine 993.056 µM -0.401452075607248 0.347995725162323 no 2180 0.344043657761097 720 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1818 st052136 56.3 µM -0.402198625041735 0.347736286712672 no 2181 0.343768927024675 715 674169 SGTC_122 0236-0016 402.397 µM -0.40233167225602 0.347690058054852 no 2182 0.343719974208396 735 6808838 SGTC_2439 5492030 7.2 µM -0.404909901892601 0.34679467285439 no 2183 0.342771869810952 722 5722370 SGTC_2726 cimetidine 79.27 µM -0.405512223725143 0.346585617431353 no 2184 0.342550517553108 731 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2 0422-0095 29 µM -0.406827261575406 0.346129353086687 no 2185 0.342067431305411 695 6790840 SGTC_2144 5628481 200 µM -0.40787594950722 0.345765661244511 no 2186 0.341682375283051 708 2818399 SGTC_2338 7999974 200 µM -0.408196438259773 0.345654542016409 no 2187 0.341564731428621 739 315925 SGTC_1605 st000082 49.1 µM -0.408345973604959 0.345602699965228 no 2188 0.341509845798668 734 1114022 SGTC_3064 1327-0027 10 µM -0.408927335007079 0.345401176690134 no 2189 0.341296494073533 703 16000455 YPR107C YTH1 SGTC_2941 9056145 11.23 µM -0.409203324688009 0.345305522886395 no 2190 0.341195227364567 752 2119517 SGTC_2855 9016525 58.44 µM -0.409726710565668 0.34512415248218 no 2191 0.341003216940077 710 43811474 SGTC_814 3342-0569 96 µM -0.412149150616589 0.344285161284604 no 2192 0.340115052533095 720 4346283 SGTC_1926 methyl fluorone black 53.6 µM -0.412188124263118 0.344271669346783 no 2193 0.34010077045228 706 72721 Reacts with homocysteine. SGTC_278 4092-0821 23.9 µM -0.413167277701629 0.343932770060475 no 2194 0.339742030287556 749 877900 SGTC_2347 9049783 174.81 µM -0.41382565046955 0.34370496809869 no 2195 0.339500898631159 777 6467988 YPL169C MEX67 SGTC_300 r073-0011 5.04 µM -0.414578091503444 0.343444687287498 no 2196 0.339225394538033 738 2735780 SGTC_2964 9083345 53.42 µM -0.414906025842014 0.343331273022345 no 2197 0.339105349213426 707 17741579 SGTC_2894 9048625 32.47 µM -0.415985892076818 0.342957907055696 no 2198 0.338710163343907 750 4092861 SGTC_2839 9003951 25.97 µM -0.416712651951319 0.342706714615506 no 2199 0.338444299525449 741 2990634 SGTC_770 0389-1121 67.2 µM -0.417273238059528 0.342513004863085 no 2200 0.338239280505291 711 6753108 SGTC_709 3807-1509 243 µM -0.41768519567426 0.342370679876887 no 2201 0.338088648851188 760 1886677 YPL242C IQG1 SGTC_1297 1068-0111 14.1 µM -0.417911250496721 0.342292590940572 no 2202 0.338006003271994 716 767057 SGTC_535 2293-4129 48.2 µM -0.417934562342446 0.342284538422455 no 2203 0.337997480911801 762 396118 YIL048W NEO1 SGTC_2228 7354201 200 µM -0.418507995295773 0.342086482343141 no 2204 0.33778787105914 729 753451 SGTC_2032 5185112 25.99 µM -0.418516868697566 0.342083417929886 no 2205 0.337784627914658 711 5718189 SGTC_1996 st072960 66.8 µM -0.419715355436815 0.341669618349695 no 2206 0.337346703095835 689 1719405 SGTC_3123 9126162 49.47 µM -0.420174393870381 0.341511177238392 no 2207 0.337179029610182 691 25239884 SGTC_2750 bromebric acid 70.15 µM -0.420541333814649 0.341384544803677 no 2208 0.337045020298139 740 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_170 4197-0004 226 µM -0.420711904400064 0.341325686294487 no 2209 0.336982733637296 717 218692 SGTC_217 ketoconazole 989 nM -0.421086548460852 0.341196422039543 no 2210 0.336845941874955 716 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1078 idebenone 36.1 µM -0.422124784094506 0.340838294749831 no 2211 0.336466969313106 726 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_495 decylubiquinone 155 µM -0.422545916176365 0.340693071001889 no 2212 0.336313296707028 756 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1396 3511-0007 98.6 µM -0.422796085690094 0.340606813390662 no 2213 0.336222021899381 731 X1396 SGTC_2709 st078560 56 µM -0.423088903136793 0.340505861503173 no 2214 0.336115199177766 751 17250903 SGTC_2861 9024595 19.48 µM -0.423288522664465 0.340437047125619 no 2215 0.336042383570687 706 16482810 SGTC_1512 0259-0544 12.2 µM -0.423295936428085 0.34043449149835 no 2216 0.33603967935605 699 18476 SGTC_1079 idarubicin 2.36 µM -0.423688925422594 0.340299033225985 no 2217 0.3358963464198 749 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3079 9117512 49.47 µM -0.423921189203235 0.340218984562325 no 2218 0.335811645216094 754 7185044 SGTC_1619 st003326 88.7 µM -0.42453162126766 0.340008636244062 no 2219 0.335589074596788 692 2849032 SGTC_2587 piperic acid 92.2 µM -0.424688986236322 0.339954418040148 no 2220 0.335531706849031 727 5370536 SGTC_1933 st074711 15.9 µM -0.426092717113186 0.339470926048784 no 2221 0.335020143414555 732 17250958 SGTC_458 nppb 133 µM -0.426810127800093 0.339223927675096 no 2222 0.334758814583586 725 4549 A chloride channel blocker. SGTC_1958 st076513 41.9 µM -0.429406847760971 0.338330477300639 no 2223 0.33381358563409 745 732122 YGL099W LSG1 SGTC_2323 6148992 148.28 µM -0.430119976046185 0.338085271057379 no 2224 0.333554184801434 725 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1975 st070967 30.8 µM -0.430493300828621 0.337956932237247 no 2225 0.333418419410194 754 261391 SGTC_913 3487-1245 167 µM -0.432762231941911 0.337177341479508 no 2226 0.33259375695922 712 4016153 SGTC_2024 5144227 134 µM -0.432823293285254 0.337156370817699 no 2227 0.332571574859019 728 3475211 SGTC_1146 3579-1023 7 µM -0.433342753122195 0.336977990091601 no 2228 0.332382891454576 739 X1146 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.434714110455242 0.336507246895266 no 2229 0.331884977467299 724 16486 A toxic proline analog. SGTC_1105 epirubicin 18.1 µM -0.435058644382588 0.336389019625231 no 2230 0.331759930306741 717 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2122 5258151 111.688 µM -0.435082243102501 0.336380922285271 no 2231 0.331751365934882 743 2173356 SGTC_113 0099-0221 2.5 µM -0.435174424867271 0.336349293030459 no 2232 0.331717912466662 703 89219 SGTC_2324 6149169 200 µM -0.436312101923741 0.335959030571715 no 2233 0.331305151306882 751 2888231 SGTC_2346 9031566 143.75 µM -0.437646164467267 0.335501626330179 no 2234 0.330821400392298 737 4771086 SGTC_1438 4092-1045 4 µM -0.438122607541661 0.335338329378285 no 2235 0.330648703439376 726 1351342 SGTC_3221 9128209 49.47 µM -0.439085003381191 0.335008571009211 no 2236 0.330299972517207 741 16460723 SGTC_2940 9060638 45.86 µM -0.439790050051865 0.3347670722533 no 2237 0.330044587371682 722 4027022 SGTC_2078 5212016 200 µM -0.439857732734291 0.334743892581395 no 2238 0.330020075212504 746 1899708 SGTC_1406 3909-7906 11.9 µM -0.441029744432567 0.334342607018662 no 2239 0.329595731814333 729 X1406 SGTC_2207 7258803 200 µM -0.441336626911871 0.33423756464425 no 2240 0.329484656882768 758 3666799 SGTC_1766 st045414 44.774 µM -0.441339547458404 0.334236565036806 no 2241 0.329483599874445 732 253960 SGTC_3285 9112818 20.8695 µM -0.442030542220609 0.334000093213444 no 2242 0.329233552385631 745 17017947 YPR165W RHO1 SGTC_3203 9113543 49.47 µM -0.442405183804498 0.333871911131118 no 2243 0.329098014264768 719 17018012 SGTC_1041 0206-0046 107 µM -0.442579178153392 0.333812386268061 no 2244 0.329035074092935 750 50494 SGTC_2480 5767542 37.17 µM -0.443289254817869 0.333569506713816 no 2245 0.328778263445692 706 2867358 SGTC_1391 3442-0225 151 µM -0.444222805592445 0.3332502946478 no 2246 0.328440752789545 707 5227075 SGTC_537 1334-0398 209 µM -0.447595961902003 0.332097908031158 no 2247 0.327222408991183 737 5846986 SGTC_3352 9151559 45.5865 µM -0.44933620790111 0.331503999423476 no 2248 0.326594570965478 713 17159339 SGTC_67 0335-0847 266 µM -0.450186804115594 0.33121386314699 no 2249 0.326287875198557 767 4552207 YOR254C SEC63 SGTC_3159 9100096 49.47 µM -0.451145414325442 0.330887004972882 no 2250 0.325942374037836 698 25236875 SGTC_2478 5763493 32.33 µM -0.451212889016055 0.330864002919763 no 2251 0.325918060514125 723 1365576 YLR208W SEC13 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.452703494047387 0.330356020185758 no 2252 0.325381131622722 748 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2880 9042983 58.44 µM -0.455926312105703 0.329258786278298 no 2253 0.324221483915902 763 6464714 SGTC_2893 9048488 25.97 µM -0.456116596842373 0.329194048170012 no 2254 0.324153068016396 729 6467338 SGTC_1293 1000-1278 195 µM -0.456872392568177 0.32893696417633 no 2255 0.323881384194188 767 678847 SGTC_1426 4048-4480 71.7 µM -0.457236687676245 0.328813078045946 no 2256 0.323750465521437 741 14224343 SGTC_3272 9137413 49.47 µM -0.458271045935418 0.328461425548119 no 2257 0.323378861583468 773 17614870 SGTC_3170 9103054 49.47 µM -0.460335457885167 0.327760038323928 no 2258 0.322637726963018 767 16432970 SGTC_678 1218-2179 85.9 µM -0.461532366245452 0.327353664725177 no 2259 0.322208352879317 749 6820081 YOR116C RPO31 SGTC_3332 9141069 11.198 µM -0.462968546152695 0.326866323737564 no 2260 0.321693456496275 735 17332883 SGTC_342 k048-0088 23.3 µM -0.463762278696002 0.326597111922514 no 2261 0.321409035861505 711 6820570 SGTC_2254 7938975 95.19 µM -0.464526113442915 0.326338125832683 no 2262 0.321135427431617 768 2969277 SGTC_661 1304-0007 33.6 µM -0.46516549354918 0.326121401731719 no 2263 0.320906473739347 720 3117130 SGTC_2367 9070478 135.38 µM -0.465208221974034 0.326106920609047 no 2264 0.320891175672866 731 572802 SGTC_2258 7960471 200 µM -0.466131285622448 0.325794148464363 no 2265 0.320560765288937 771 2974708 SGTC_2374 9071832 200 µM -0.466159695538288 0.325784523952989 no 2266 0.320550598220718 760 17381698 SGTC_1787 fluconazole 80 µM -0.466305492065537 0.325735133858396 no 2267 0.320498424076482 745 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_307 1501-1223 22.3 µM -0.468605120140411 0.324956515923235 no 2268 0.319675958404758 757 2830329 SGTC_2075 5212009 200 µM -0.46971971642604 0.324579405779119 no 2269 0.319277639767255 769 780898 SGTC_425 3825-7017 13.1 µM -0.469768807076898 0.324562800683085 no 2270 0.31926010123616 754 3397440 SGTC_2203 7227154 166.4 µM -0.470550863460908 0.324298314240436 no 2271 0.318980751885382 731 896304 SGTC_1451 4152-0210 104 µM -0.472527369839272 0.323630267758167 no 2272 0.318275205243597 778 659563 SGTC_2787 5284540 71.43 µM -0.472567336538158 0.323616765121695 no 2273 0.318260945255992 766 736958 SGTC_1070 indatraline 8.81 µM -0.474009977747278 0.323129528446003 no 2274 0.317746396040032 761 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2371 9071574 200 µM -0.474994389274777 0.322797227985737 no 2275 0.317395486207512 755 45596039 SGTC_3015 9080845 49.47 µM -0.476438540429446 0.322309992643674 no 2276 0.316880991476714 760 5296973 SGTC_147 4466-0538 29.23 µM -0.476889683787366 0.32215784602325 no 2277 0.316720339196661 760 6742687 YHR072W ERG7 SGTC_858 0438-0351 2.77 µM -0.477034214176012 0.32210910992351 no 2278 0.316668879191702 744 2799119 SGTC_1982 st072467 71.9 µM -0.478477369783919 0.321622641200214 no 2279 0.316155238750062 760 3163533 SGTC_1820 st053765 18.6 µM -0.478529767246947 0.321604984452646 no 2280 0.31613659638264 744 3690829 SGTC_398 bronopol 33.3 µM -0.47984816588388 0.32116084696282 no 2281 0.315667680450394 737 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1253 0550-0034 176 µM -0.481204651699026 0.320704145648282 no 2282 0.315185527557874 721 5969915 SGTC_2476 5806916 10.51 µM -0.481675856055569 0.320545564122571 no 2283 0.315018115032448 736 2870194 SGTC_1180 1193-0155 285 µM -0.481783107156086 0.320509473863223 no 2284 0.31498001547606 781 2921347 SGTC_2163 5671233 125 µM -0.483505329021215 0.319930174588523 no 2285 0.314368488438313 717 701023 SGTC_319 1348-1596 45.5 µM -0.484464330093669 0.319607788018508 no 2286 0.314028186603577 766 5380505 SGTC_2910 7948405 25.97 µM -0.48474332457236 0.319514024260852 no 2287 0.313929214995533 755 2971328 SGTC_3074 9116018 49.47 µM -0.487104490723202 0.318720952025934 no 2288 0.31309214208586 786 17027303 SGTC_1755 st041960 45.185 µM -0.487136700695917 0.318710139016633 no 2289 0.313080729755909 781 2257073 SGTC_2764 methyldopa 94.69 µM -0.487236244526241 0.318676722753087 no 2290 0.31304546146838 778 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1609 st001574 46.4 µM -0.488112999666762 0.318382465049948 no 2291 0.312734901839001 774 3960012 SGTC_2255 7941087 197.44 µM -0.488941230407566 0.318104598371392 no 2292 0.312441652315687 749 935561 SGTC_3049 9092223 49.47 µM -0.489069690696281 0.318061509843333 no 2293 0.312396179344237 767 8623917 SGTC_2891 9063876 19.48 µM -0.489914753629603 0.317778117752132 no 2294 0.312097111267677 767 6472478 SGTC_1635 st007035 42.4 µM -0.489981453543223 0.317755754458991 no 2295 0.312073511413044 759 3716403 SGTC_280 3448-3607 3.04 µM -0.490960866202427 0.317427451425688 no 2296 0.311727063140547 753 626179 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.494284081393102 0.316314567651812 no 2297 0.310552782883532 778 1273210 SGTC_108 0509-0257 621.132 µM -0.494669098859164 0.31618573958785 no 2298 0.310416858787477 741 536624 SGTC_509 pifithrin 175 µM -0.495293624540263 0.315976818768063 no 2299 0.310196435301634 766 4817 A p53 inhibitor. SGTC_1081 sertraline 6 µM -0.496589234322908 0.315543589522157 no 2300 0.309739373232074 765 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1429 4049-0205 9.46 µM -0.496661826818355 0.315519323352957 no 2301 0.309713772919641 746 22774478 SGTC_665 3914-0008 307 µM -0.498479949787802 0.31491182215735 no 2302 0.30907289891234 767 1069549 SGTC_1050 3232-1156 69.3 µM -0.499051529520715 0.314720939837791 no 2303 0.308871541436799 776 700529 SGTC_1887 st057648 70.8 µM -0.501622670138759 0.313862905436611 no 2304 0.307966484773383 772 688672 SGTC_1481 3346-2004 36 µM -0.502657570574348 0.313517824702322 no 2305 0.307602522729643 779 2770522 SGTC_2936 9038235 15.59 µM -0.504858397634008 0.312784516070449 no 2306 0.306829147950846 745 4749415 SGTC_1768 st044301 37.178 µM -0.505422092565448 0.312596813669123 no 2307 0.306631202532697 807 3931349 SGTC_2713 st079149 53.4 µM -0.506544802991231 0.312223111874116 no 2308 0.306237122953414 742 3103253 SGTC_2321 7390090 138.78 µM -0.50666138539736 0.312184317688911 no 2309 0.306196214509657 773 649046 SGTC_1530 rhein 70.4 µM -0.507481619565559 0.311911433879107 no 2310 0.305908464937104 752 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_90 0870-0863 4.608 µM -0.508258617597734 0.311653029490343 no 2311 0.30563599365079 791 1738164 SGTC_2270 7924575 90.91 µM -0.508371373086267 0.311615538366576 no 2312 0.305596462418312 764 1262135 SGTC_2013 4024628 200 µM -0.509053091707188 0.311388908991849 no 2313 0.305357505237007 785 5230760 SGTC_3090 9117696 49.47 µM -0.509143433708132 0.311358881211694 no 2314 0.305325844623729 770 7923821 SGTC_2751 anetholtrithion 17.25 µM -0.509741545399101 0.311160113137705 no 2315 0.305116271411216 768 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2842 9000675 19.48 µM -0.509898761723546 0.311107875199333 no 2316 0.305061194759022 744 2989072 SGTC_1284 0929-0043 16 µM -0.511314745263055 0.310637560880058 no 2317 0.304565340809763 756 1239883 SGTC_2686 alizarin 95.37 µM -0.512835697056309 0.310132726231849 no 2318 0.304033128505838 728 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2871 9038510 12.99 µM -0.513695547049003 0.309847482818657 no 2319 0.303732432865459 804 4945164 SGTC_1168 k815-0004 80.5 µM -0.514804818490938 0.3094796663306 no 2320 0.303344708951635 754 642433 SGTC_412 gemfibrozil 100 µM -0.514878355711163 0.309455289315221 no 2321 0.303319013288902 751 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1893 st059353 36.1 µM -0.515569607368958 0.309226185772082 no 2322 0.303077521003595 815 3112488 SGTC_3240 9133527 49.47 µM -0.515932350706751 0.309105990357698 no 2323 0.302950829192583 795 17617455 SGTC_75 0159-0059 199.013 µM -0.515949924375859 0.309100167821408 no 2324 0.302944692011397 814 5377270 SGTC_511 blebbistatin 171 µM -0.518933781723671 0.308112247700878 no 2325 0.301903459587017 771 3476986 A myosin inhibitor. SGTC_3299 9121982 43.1275 µM -0.521492892672754 0.307266061856519 no 2326 0.301011727709808 777 17594604 YPL160W CDC60 SGTC_1546 5-methoxyflavanone 78.7 µM -0.522112706359914 0.307061270663667 no 2327 0.300795930029682 765 147795 SGTC_3068 9116768 49.47 µM -0.523597988147315 0.30657076713424 no 2328 0.300279090555238 789 41904888 SGTC_705 1124-0212 310 µM -0.523872055644726 0.306480296150411 no 2329 0.300183766071024 798 9554485 SGTC_3158 9100007 49.47 µM -0.523878633384908 0.306478124952008 no 2330 0.300181478409729 750 19297233 SGTC_2867 9039098 71.43 µM -0.524150988684605 0.306388231137258 no 2331 0.300086763335504 744 6463460 SGTC_220 paclitaxel 373.376 µM -0.524692851713322 0.30620941803278 no 2332 0.29989836367923 766 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2955 9076254 12.21 µM -0.52528473733112 0.306014150371854 no 2333 0.299692632936012 766 16459619 SGTC_53 0973-0023 39.979 µM -0.527196741485678 0.30538374215407 no 2334 0.299028485634006 790 674768 SGTC_1346 1488-2224 62.4 µM -0.527633098786247 0.305239951245471 no 2335 0.298877007752665 766 3722427 SGTC_1900 st060200 72.8 µM -0.528965213978106 0.30480117114199 no 2336 0.298414790630579 751 688945 SGTC_2769 toremifene 3.73 µM -0.529025125992605 0.304781443552112 no 2337 0.298394010015543 759 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1335 1486-0900 202 µM -0.529389805591628 0.30466137554759 no 2338 0.298267534296039 752 X1335 SGTC_343 4130-2827 29.8 µM -0.529582965899542 0.304597787497295 no 2339 0.298200553630452 753 1118244 SGTC_89 0302-0250 142.109 µM -0.530817119251617 0.30419164571836 no 2340 0.297772757886596 787 4203518 YLR208W SEC13 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.53169678484075 0.303902308012316 no 2341 0.297468009555511 787 689007 SGTC_2114 5491910 81.25 µM -0.532522100075636 0.30363095875962 no 2342 0.297182219739006 777 2849228 SGTC_2153 5569715 200 µM -0.53400988799135 0.303142073500932 no 2343 0.296667346482723 758 2054701 SGTC_2953 9074162 66.49 µM -0.535294607987377 0.302720199593819 no 2344 0.296223077153354 764 16451992 SGTC_3234 9132280 49.47 µM -0.535779972823069 0.302560884889648 no 2345 0.296055312485337 763 17612295 SGTC_2872 9044037 25.97 µM -0.537364474899891 0.302041054456318 no 2346 0.295507938645052 773 6465195 SGTC_1780 st038448 24.544 µM -0.538150206409247 0.30178342696125 no 2347 0.295236676653403 793 728868 YDL195W SEC31 SGTC_1681 tripelennamine 100 µM -0.54222388460574 0.300449326424433 no 2348 0.293832141663226 740 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_722 3534-0461 190 µM -0.54331175002633 0.300093509491796 no 2349 0.293457587767768 760 658262 SGTC_2243 6634756 200 µM -0.543898396905047 0.299901709297001 no 2350 0.293255696093395 740 885676 SGTC_2990 9074105 71.4286 µM -0.544786021168251 0.299611612139908 no 2351 0.292950346981906 791 6502001 SGTC_414 piperonyl butoxide 100 µM -0.545092369805442 0.299511519491105 no 2352 0.292844995111818 774 5794 A potent inhibitor of cytochrome P450. SGTC_677 0929-0063 136 µM -0.54561215717098 0.299341725138704 no 2353 0.292666282905013 792 1539583 SGTC_47 0149-0135 24.25 µM -0.548183679495777 0.298502351665951 no 2354 0.291782893634039 756 5239155 SGTC_80 0159-0065 512.242 µM -0.548721164798806 0.298327045871863 no 2355 0.291598409614433 742 1548079 SGTC_2265 7929201 200 µM -0.54981344800039 0.297970932104427 no 2356 0.291223666932124 800 1265108 SGTC_1990 st072050 59.8 µM -0.550275724414496 0.297820275910799 no 2357 0.291065135965337 773 17233948 SGTC_128 0906-2981 13.371 µM -0.550326383600879 0.297803768160284 no 2358 0.291047765585876 791 6740226 SGTC_1654 st012436 41.8 µM -0.550478410257428 0.297754231415478 no 2359 0.290995640519978 783 4323132 SGTC_3112 9123419 49.47 µM -0.550948904816909 0.297600948118127 no 2360 0.290834350664682 803 17015854 SGTC_2851 9015922 71.43 µM -0.551403171755166 0.297452985831905 no 2361 0.290678663452676 796 2996893 SGTC_3124 9127567 49.47 µM -0.552676709891571 0.297038352533756 no 2362 0.290242402049707 778 17592030 SGTC_1086 cerivastatin 2.18 µM -0.553580717961775 0.29674418982484 no 2363 0.289932912587531 764 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1936 st074407 74.3 µM -0.553825751942803 0.296664479160001 no 2364 0.289849051246924 772 809813 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.55615984470317 0.295905680287307 no 2365 0.28905079363943 761 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2625 euphol 100 µM -0.556612911553481 0.29575849445734 no 2366 0.288895965109347 792 6708538 A triterpene alcohol. SGTC_3002 9075603 71.4286 µM -0.557531078453029 0.295460316830379 no 2367 0.288582315640639 783 20105405 SGTC_2864 9034755 47.6 µM -0.560382775966495 0.294535101765712 no 2368 0.287609188711217 759 4930451 SGTC_614 0462-0418 107 µM -0.56119217277267 0.2942727419295 no 2369 0.2873332691333 766 5188303 SGTC_2532 xanthone 78.9 µM -0.565228807480192 0.292965911860595 no 2370 0.285959072454507 775 7020 An insecticide. SGTC_339 3091-4833 71.4 µM -0.566836304868551 0.292446247468173 no 2371 0.285412701145495 784 3240077 SGTC_183 3914-0051 30.55 µM -0.567264626620043 0.292307853907597 no 2372 0.285267203047368 785 1596232 SGTC_292 k038-0015 474 µM -0.567811025717398 0.292131353009228 no 2373 0.285081646156829 798 46368540 SGTC_2320 7373003 200 µM -0.569412268539159 0.291614396436542 no 2374 0.284538196452372 784 5415828 SGTC_2647 atorvastatin 60.16 µM -0.569965962458473 0.291435737259821 no 2375 0.284350392116191 774 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1042 0350-0096 82 µM -0.570052397536184 0.291407852055251 no 2376 0.284321080033211 768 3122515 SGTC_1531 st059297 52.4 µM -0.571416506370159 0.290967935777287 no 2377 0.283858671332907 778 7566702 SGTC_2767 sibutramine 71.45 µM -0.572048459802437 0.290764240115168 no 2378 0.283644572413634 798 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_900 1112-0045 141 µM -0.572315792003012 0.290678091799449 no 2379 0.283554026472918 784 56211 YIL048W NEO1 SGTC_119 0121-0043 24.815 µM -0.57242137703862 0.29064407010774 no 2380 0.283518268429977 803 1092378 SGTC_727 3032-0951 202 µM -0.572541209606738 0.29060545982196 no 2381 0.283477687852958 780 3652836 SGTC_1679 SEC14.276 6.7 µM -0.575840077495826 0.289543501755565 no 2382 0.282361640760087 776 1005053 YMR079W SEC14 SGTC_1884 5633444 25 µM -0.577700692147014 0.28894534512999 no 2383 0.281733105893807 774 5724239 SGTC_451 chloral hydrate 100 µM -0.579115103776672 0.288491024705089 no 2384 0.281255754699072 814 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1713 st033146 12.748 µM -0.579698146254713 0.288303844794582 no 2385 0.281059096835908 810 674619 SGTC_982 1491-0518 27.5 µM -0.581350728678636 0.287773611313894 no 2386 0.280502048770873 791 3091256 SGTC_206 4546-0025 72.014 µM -0.582227616525348 0.287492447774985 no 2387 0.280206686917507 823 6620745 YIL048W NEO1 SGTC_2466 5983409 37.09 µM -0.583110086499068 0.287209625604534 no 2388 0.279909597039012 783 2879657 SGTC_1770 st043884 66.3 µM -0.583353974755137 0.287131485265344 no 2389 0.27982751724943 815 670149 SGTC_2026 5148700 152 µM -0.583456444596554 0.287098657543874 no 2390 0.279793034845173 765 79838 SGTC_2467 5474540 200 µM -0.583494774569159 0.287086378429877 no 2391 0.279780136851915 764 5413519 SGTC_1608 st001473 40.5 µM -0.58446695748276 0.286775020086956 no 2392 0.279453094858011 818 7292267 SGTC_1334 1486-0610 236 µM -0.584537608853333 0.286752399007603 no 2393 0.27942933500007 775 3742339 SGTC_460 trequinsin 123 µM -0.585866682269704 0.286327015430639 no 2394 0.278982554268074 809 5537 A vasodilator. SGTC_2267 7931562 200 µM -0.585911297526343 0.286312741058728 no 2395 0.278967562453004 770 934880 SGTC_2929 9013348 24.6 µM -0.586017646621347 0.286278716694481 no 2396 0.278931828142091 778 2995952 SGTC_506 n9-isopropylolomoucine 153 µM -0.586267838906724 0.286198680017247 no 2397 0.278847769929037 800 6610355 SGTC_297 0986-0032 24 µM -0.586489309163143 0.286127840404722 no 2398 0.278773371870442 797 2847425 SGTC_1449 4112-4002 201 µM -0.586881969951011 0.286002264163599 no 2399 0.27864148987528 780 2059539 SGTC_1881 5652484 16 µM -0.587452729409045 0.285819777182988 no 2400 0.278449844518075 804 2255129 SGTC_890 0929-0006 47.2 µM -0.58772815982866 0.285731734563694 no 2401 0.278357385524296 784 1378169 SGTC_209 4077-0173 175.592 µM -0.587915916797886 0.285671724567669 no 2402 0.278294366131503 769 15993494 SGTC_2978 9011784 42.97 µM -0.588786048711081 0.285393695432276 no 2403 0.278002402912729 777 2994934 SGTC_2846 9008642 19.48 µM -0.590157190160921 0.284955842793917 no 2404 0.277542634980232 837 2992898 SGTC_2595 hexamethylquercetagetin 100 µM -0.590458773660562 0.284859579807867 no 2405 0.277441558583642 815 386331 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.591812090030006 0.284427803415093 no 2406 0.276988213188465 779 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2773 thioridazine 9.09 µM -0.593645829983043 0.283843246971266 no 2407 0.276374510606608 801 5452 An antipsychotic. SGTC_2744 captopril 92.04 µM -0.593979654889935 0.283736892756036 no 2408 0.276262860347176 766 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1198 1612-1005 86.7 µM -0.597078652058296 0.282750486520262 no 2409 0.275227435019087 798 6998509 SGTC_1600 coumarin 106 71.1 µM -0.600478462558046 0.281670230685793 no 2410 0.274093705143237 823 100336 A hepatotoxic, DNA x-linker. SGTC_1003 4049-0218 100 µM -0.600874401133691 0.281544554641217 no 2411 0.273961822236076 807 295161 SGTC_588 3970-1144 52.9 µM -0.602252841145489 0.281107231008144 no 2412 0.273502923423597 770 1888707 SGTC_1746 st038117 42 µM -0.602925000339549 0.280894100981526 no 2413 0.273279291844975 793 2898218 SGTC_1693 xanthone 101.9 µM -0.603236948135542 0.280795214288629 no 2414 0.273175535637672 817 7020 An insecticide. SGTC_237 nikkomycin 200 µM -0.603665560589851 0.280659372642563 no 2415 0.273033007719935 815 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_932 2857-0803 154 µM -0.604536021096054 0.280383592428893 no 2416 0.272743664107248 804 674898 SGTC_1326 1431-2094 10.8 µM -0.604986186182042 0.28024102214536 no 2417 0.272594087626573 821 616278 SGTC_2884 9058502 51.95 µM -0.608460999909542 0.279141708800012 no 2418 0.27144088234846 797 6471554 SGTC_487 nimodipine 119 µM -0.609047303708494 0.27895642905792 no 2419 0.271246542439765 789 4497 L-type voltage-gated calcium channels inhibitor SGTC_211 3455-0679 143.504 µM -0.609567974427245 0.278791940404247 no 2420 0.271074015847202 776 748649 SGTC_462 ag-879 158 µM -0.612164314958435 0.277972418012478 no 2421 0.270214524453241 816 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_1342 1486-1464 234 µM -0.613836017432499 0.277445376056502 no 2422 0.269661846966979 809 3253938 SGTC_1138 3761-0006 1.03 µM -0.614681298613982 0.277179068143585 no 2423 0.269382606323935 798 12061087 SGTC_1084 voriconazole 435 nM -0.617185551354205 0.276390832026302 no 2424 0.26855617239412 823 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3058 9093861 49.47 µM -0.617199794277661 0.276386352083983 no 2425 0.268551475702957 807 17217477 SGTC_1413 3910-0535 34.4 µM -0.617544866810213 0.27627782450521 no 2426 0.268437698542716 798 2876951 SGTC_3089 9117425 49.47 µM -0.619901886021631 0.275537086152007 no 2427 0.267661191999298 836 9401657 SGTC_2103 5378138 10 µM -0.620077784169182 0.27548184598647 no 2428 0.267603288785525 804 244142 SGTC_3292 9120825 59.784 µM -0.623135911742095 0.274522323888041 no 2429 0.266597606185084 822 24824900 SGTC_781 4335-2806 94.4 µM -0.624327478995598 0.274148903126311 no 2430 0.266206270564646 832 845254 SGTC_976 1348-1067 47.6 µM -0.626256413294403 0.273544934054556 no 2431 0.265573385194436 813 5310671 YGL099W LSG1 SGTC_2956 9076196 2.52 µM -0.627506935200588 0.273153735008674 no 2432 0.265163495789769 834 16423868 SGTC_3053 9095903 49.47 µM -0.627999253538735 0.272999799831446 no 2433 0.265002214493386 848 17174018 SGTC_2496 diffractaic acid 79.83 µM -0.62891513999726 0.272713540363598 no 2434 0.264702306834074 814 94870 An apoptosis inducer which activates caspases. SGTC_2926 9010726 65.15 µM -0.62907305074419 0.272664200563267 no 2435 0.264650616300553 809 2994293 SGTC_833 3852-0053 558 µM -0.629150331790131 0.272640055427666 no 2436 0.264625320979731 822 3123681 SGTC_1177 0983-0204 23.6 µM -0.62941197190989 0.272558318344579 no 2437 0.264539691119923 805 766818 SGTC_1221 2958-7315 257 µM -0.629742579364202 0.272455053080319 no 2438 0.264431509722492 803 4562705 SGTC_660 4031-1742 102 µM -0.630187240271437 0.272316193858399 no 2439 0.264286043261193 798 6738706 SGTC_2681 menadione 3.18 µM -0.630201443019519 0.272311759187351 no 2440 0.264281397642841 819 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_835 0312-0010 67.2 µM -0.630515843471204 0.272213599869366 no 2441 0.264178570129989 809 1626196 SGTC_32 0928-0142 34.1 µM -0.631965885580618 0.271761108300374 no 2442 0.263704584608645 817 2244242 SGTC_1006 4099-6547 255 µM -0.632850094042771 0.27148537128446 no 2443 0.26341577018007 825 3146833 SGTC_3023 9089636 49.47 µM -0.634853946302207 0.270860993879541 no 2444 0.262761837826226 819 17249241 SGTC_1412 3909-8563 178 µM -0.636115536519998 0.270468264795948 no 2445 0.262350559869034 827 23767530 SGTC_1320 1313-0481 95.3 µM -0.636786406900792 0.270259540893615 no 2446 0.262131990710153 807 6813365 YLR208W SEC13 SGTC_1039 k821-0043 94 µM -0.637649258604907 0.269991205448618 no 2447 0.26185101140939 796 15992768 SGTC_2850 9015429 58.44 µM -0.637733722222278 0.269964945549115 no 2448 0.261823514953321 836 6457570 SGTC_655 k060-0012 42 µM -0.638440402349973 0.269745287450501 no 2449 0.261593518926894 822 5994525 SGTC_2495 cafestol 54.53 µM -0.63930299124409 0.269477289433812 no 2450 0.261312921461393 829 16667697 An anti-infammatory. SGTC_2436 5633522 8.09 µM -0.639377993993891 0.269453993113809 no 2451 0.261288530610202 820 5724242 SGTC_382 3229-0966 23.2 µM -0.641642588307374 0.268751071802969 no 2452 0.260552637016082 823 5722370 SGTC_1510 1123-0200 71.5 µM -0.642149811334897 0.268593758096063 no 2453 0.260387958218031 831 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2143 5623677 140.463 µM -0.645186508924847 0.267652904396068 no 2454 0.259403163928343 796 5375313 SGTC_83 0170-0301 39.027 µM -0.645327633319223 0.267609220544792 no 2455 0.259357444430596 812 3089716 SGTC_2586 curcumin 80 µM -0.646935621043024 0.267111735585684 no 2456 0.258836805286817 810 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2097 5376186 200 µM -0.647598361919747 0.26690683041803 no 2457 0.258622378522212 803 742755 SGTC_2516 gossypol 71.55 µM -0.647633920152704 0.266895838825157 no 2458 0.258610876419637 815 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3184 9108758 49.47 µM -0.648641364512459 0.266584517437004 no 2459 0.258285106192929 828 902885 SGTC_2166 5933061 31.504 µM -0.649151841764727 0.26642683941003 no 2460 0.258120117963159 819 2877375 SGTC_1330 1469-0054 61.8 µM -0.649769477754171 0.266236124910702 no 2461 0.257920568697123 817 7102664 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.651107335017646 0.265823256585431 no 2462 0.257488600952816 830 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2287 7945887 168.79 µM -0.651309640996781 0.265760852374542 no 2463 0.257423313066043 808 1245853 SGTC_1725 st036284 20.55 µM -0.651522260310522 0.265695274871067 no 2464 0.257354706146161 808 707914 SGTC_353 1988-1175 58.3 µM -0.653043651484248 0.265226276511309 no 2465 0.256864068764247 813 2788357 SGTC_1934 st074720 32.6 µM -0.654044196176203 0.264918068472254 no 2466 0.256541666048104 822 17250992 SGTC_1248 0469-0687 58.6 µM -0.65407241449228 0.264909378734932 no 2467 0.256532576396258 815 4017482 SGTC_761 k216-0224 480 µM -0.654481080564462 0.264783547609289 no 2468 0.25640095615648 858 1340404 SGTC_618 k072-0232 33.2 µM -0.654690644866898 0.264719033092199 no 2469 0.256333474840109 818 5872756 YGL099W LSG1 SGTC_1061 3448-9325 110 µM -0.654708199460915 0.26471362926101 no 2470 0.256327822546094 825 723482 SGTC_256 clotrimazole 625 nM -0.656545202641666 0.264148454769337 no 2471 0.255736696649473 798 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_1865 st057639 52.2 µM -0.659966944879623 0.263097358919138 no 2472 0.254637520978688 829 688818 SGTC_110 0850-0284 111.64 µM -0.660244887435165 0.263012074060737 no 2473 0.254548345507748 795 3906265 SGTC_1093 fluphenazine 7.97 µM -0.660296037127846 0.262996380651115 no 2474 0.254531936352773 829 6602611 An atypical antipsychotic. SGTC_3166 9102297 49.47 µM -0.660548178028074 0.262919027447235 no 2475 0.254451056007444 812 25237072 SGTC_1903 st060211 78.3 µM -0.663169957435613 0.262115393083407 no 2476 0.253610855029653 806 688960 SGTC_2975 9084847 53.72 µM -0.663450824310858 0.262029375781061 no 2477 0.253520932193083 794 27211724 SGTC_1972 st070201 17.4 µM -0.664654712956704 0.261660841082058 no 2478 0.253135682942847 813 2829099 SGTC_2218 6965428 192.983 µM -0.665776475142979 0.261317686506831 no 2479 0.252776991814045 816 675684 SGTC_1496 4469-0713 57.4 µM -0.666340554612338 0.261145218207069 no 2480 0.252596724715562 832 746691 SGTC_2368 9071271 200 µM -0.669526092485275 0.260172333600084 no 2481 0.251579970998194 833 27209959 SGTC_1159 4092-0538 61.2 µM -0.670500002959967 0.259875268130512 no 2482 0.25126955228083 841 717301 SGTC_2616 abietic acid 100 µM -0.670764214335528 0.25979470766693 no 2483 0.251185373978129 833 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1631 benzylvanillin 81.9 µM -0.670785707261899 0.259788154844022 no 2484 0.251178526942404 809 75506 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.672453432438891 0.259279954355782 no 2485 0.250647538217546 844 688798 SGTC_2273 7815444 169.05 µM -0.672661378562087 0.259216623649549 no 2486 0.250581371752982 858 2824616 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.672849105024614 0.259159457778215 no 2487 0.250521646939213 808 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1460 k062-0059 9.15 µM -0.673608683185834 0.25892821997964 no 2488 0.250280065627744 806 1373085 SGTC_2245 6637752 200 µM -0.673732439848476 0.258890554947477 no 2489 0.250240716937353 830 681890 SGTC_2455 5377712 9.75 µM -0.674447545954093 0.25867296970916 no 2490 0.250013411710258 802 2243908 SGTC_2824 7998404 51.95 µM -0.674518221616394 0.258651470376624 no 2491 0.249990952536507 846 837851 SGTC_1523 st012844 44.7 µM -0.67485423841162 0.258549267693171 no 2492 0.249884188422996 831 4274103 SGTC_898 1000-0849 28.3 µM -0.675725465039343 0.25828437332541 no 2493 0.249607482472097 837 6751807 SGTC_1431 4049-0260 9.09 µM -0.676233270187342 0.258130041296859 no 2494 0.249446276123072 836 3854841 SGTC_969 1313-0238 134 µM -0.677242824362032 0.257823359898654 no 2495 0.24912595040322 840 5212874 SGTC_2541 muurolladie-3-one 83.07 µM -0.679053249035125 0.257273864804312 no 2496 0.248552061553508 841 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_13 0199-0087 65 µM -0.679619511740374 0.257102119375305 no 2497 0.248372705919887 822 4589825 SGTC_2618 avocadyne 43.43 µM -0.680179430460015 0.256932356698187 no 2498 0.248195427508218 829 3015189 SGTC_2137 5261020 140 µM -0.681087354164424 0.25665720582932 no 2499 0.247908109142238 821 763655 SGTC_3009 9080819 71.4286 µM -0.681835487114879 0.256430595715582 no 2500 0.247671491071866 825 17027216 SGTC_1045 1348-1485 165 µM -0.682897126449648 0.256109203277462 no 2501 0.247335924927679 818 6810614 SGTC_1324 1418-0026 34.4 µM -0.683551331511784 0.255911258989516 no 2502 0.247129262921838 829 1372513 SGTC_693 4161-2696 114 µM -0.683728847478936 0.255857561360356 no 2503 0.247073201935452 846 805759 SGTC_1870 st057514 26.5 µM -0.684502099443931 0.255623725398848 no 2504 0.246829082055528 837 5393161 SGTC_815 1582-0027 36.9 µM -0.689898393660738 0.253994966751423 no 2505 0.245129043043819 847 3128206 SGTC_165 k038-0023 64.381 µM -0.690953089480995 0.253677266195941 no 2506 0.244797510733291 833 46368543 SGTC_2303 7774051 200 µM -0.691237244227936 0.253591707435558 no 2507 0.244708231030151 854 2953184 SGTC_1575 cyproterone acetate 48 µM -0.69252309621624 0.253204728039756 no 2508 0.244304443368648 847 9880 An androgen receptor antagonist and liver toxin. SGTC_1873 rapamycin 2 nM -0.693857721299318 0.252803398974411 no 2509 0.243885719929767 819 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1216 1165-0504 9.65 µM -0.695261823599141 0.252381539504593 no 2510 0.243445617176158 841 6304004 SGTC_550 4123-0385 25.7 µM -0.695595121054968 0.252281455533806 no 2511 0.243341211250152 833 5731123 SGTC_2195 6536160 144.242 µM -0.695837168760895 0.25220878554294 no 2512 0.243265404614754 816 3834386 SGTC_133 0724-0033 378.92 µM -0.695842329361644 0.252207236295801 no 2513 0.243263788511286 830 280309 SGTC_272 doxorubicin 8.13 µM -0.699517312097812 0.251105257234717 no 2514 0.242114398879088 844 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2972 9093619 59.92 µM -0.700012163823503 0.250957065986639 no 2515 0.24195985403751 815 25236256 SGTC_2028 5153890 36.43 µM -0.700826277291789 0.25071336745563 no 2516 0.241705718518872 839 2830968 YPR165W RHO1 SGTC_1756 st041558 35.5 µM -0.70199729050877 0.250363053661137 no 2517 0.24134042658858 859 3955792 SGTC_1013 4112-3890 241 µM -0.702034477041327 0.250351933397364 no 2518 0.24132883134493 846 705171 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.704657438946431 0.249568223676684 no 2519 0.240511721928947 863 5393153 SGTC_2934 9036370 36.88 µM -0.704921481269316 0.249489403251769 no 2520 0.240429550572629 824 6462800 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.704989388755365 0.249469134030786 no 2521 0.240408419878878 855 91467 include heat shock SGTC_1275 0867-0008 21.1 µM -0.706689901026394 0.248961845720791 no 2522 0.2398796034138 836 3422836 SGTC_2484 5809818 12.04 µM -0.709574465728737 0.248102593769407 no 2523 0.238984029297031 823 2870548 SGTC_818 4072-2707 53.5 µM -0.711047448346265 0.247664433744779 no 2524 0.23852741675144 845 882871 SGTC_51 1013-0126 23.419 µM -0.711864288927957 0.247421630931762 no 2525 0.238274408860955 829 1627850 SGTC_289 k017-0060 526 µM -0.711891603076189 0.24741351410185 no 2526 0.238265951127877 849 5512909 SGTC_1366 1683-0113 21.9 µM -0.715876740716027 0.246230794169642 no 2527 0.237033730798387 843 708623 SGTC_92 0063-0024 660.874 µM -0.718126106280512 0.245564562234923 no 2528 0.236339767324521 852 3594437 SGTC_386 1509-0011 3.07 µM -0.718329594498019 0.245504339549856 no 2529 0.236277043337199 833 3107280 SGTC_260 nsc-65238 3.989 µM -0.719390845645128 0.245190389104537 no 2530 0.235950067833895 847 3246252 SGTC_2352 9027995 87.8 µM -0.719393587840001 0.245189578159414 no 2531 0.235949223276402 833 2997347 SGTC_2297 7971671 152.32 µM -0.719916955836883 0.245034829745286 no 2532 0.235788063793823 842 909016 SGTC_1341 1486-1360 280 µM -0.721523503307284 0.244560137315387 no 2533 0.235293742688136 861 3976547 SGTC_1121 fusaric acid 630.51 nM -0.722636044578151 0.244231701199847 no 2534 0.234951758687944 834 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_362 0310-0100 9.03 µM -0.722663732832882 0.244223530314078 no 2535 0.23494325110104 827 790235 SGTC_50 0929-0078 56.389 µM -0.724605491464297 0.243650879352117 no 2536 0.234347044520607 820 1377751 SGTC_1483 3453-0561 55.9 µM -0.724817958396098 0.243588264008241 no 2537 0.234281858549092 863 4546991 SGTC_444 curcumin 90.4 µM -0.726242172827255 0.243168763496571 no 2538 0.233845161303553 834 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_729 4092-0585 94.1 µM -0.726428121080017 0.243114021523123 no 2539 0.23378817855772 839 2169061 SGTC_1904 st060225 78 µM -0.729660043635108 0.242163629568387 no 2540 0.232799005175621 823 66595 SGTC_2945 9067681 61.76 µM -0.730194318904746 0.242006712700929 no 2541 0.232635707329755 876 16456930 SGTC_1932 st074806 40.9 µM -0.730729588634779 0.241849559077335 no 2542 0.232472169405446 854 17251235 SGTC_3092 9117248 49.47 µM -0.733597507486376 0.241008490421851 no 2543 0.231597040247851 870 17141857 SGTC_2919 7978188 46.38 µM -0.733820252472328 0.240943233092478 no 2544 0.231529147809634 823 2980291 SGTC_357 1325-0123 420 µM -0.733998443717318 0.24089103553895 no 2545 0.231474843294009 860 1098503 SGTC_1991 st073000 8.92 µM -0.734857752852046 0.240639404532884 no 2546 0.231213065017778 860 4301969 YIL048W NEO1 SGTC_1606 st000094 49.2 µM -0.735392396391757 0.24048291740331 no 2547 0.231050275629713 828 1242210 SGTC_3310 9130229 44.1445 µM -0.736528490402484 0.24015057321249 no 2548 0.230704567830677 859 7761258 SGTC_866 0495-0101 262 µM -0.737997489617507 0.239721214885929 no 2549 0.230257987315436 836 635694 SGTC_2693 st077581 40.7 µM -0.738287062541993 0.239636628113864 no 2550 0.230170013288832 848 25238761 SGTC_702 1488-0190 94 µM -0.738848337238376 0.239472721288513 no 2551 0.229999548155757 827 949357 SGTC_697 0508-1955 564 µM -0.739479282469532 0.239288541962956 no 2552 0.229808007717483 842 6243113 SGTC_2966 9084041 48.03 µM -0.740623905307317 0.23895461255288 no 2553 0.229460754681786 840 17741380 SGTC_3271 9137798 49.47 µM -0.741858086580254 0.238594841266536 no 2554 0.229086661309979 810 6498326 SGTC_14 0354-0009 295 µM -0.742556208698861 0.238391465810004 no 2555 0.22887520471026 866 1713507 SGTC_1213 1315-0166 115 µM -0.743128366446061 0.238224856835543 no 2556 0.2287019836015 836 768401 SGTC_2434 5670830 169.91 µM -0.744533422596519 0.23781598355177 no 2557 0.228276914487902 879 1549830 SGTC_2105 5350118 200 µM -0.744633089063148 0.237786995097961 no 2558 0.228246779447373 862 2133313 SGTC_2555 cholic acid 100 µM -0.745838097260314 0.237436666291291 no 2559 0.227882611540548 854 6708657 Influences liver metabolism. SGTC_2008 4012253 172 µM -0.747011941200422 0.23709567041931 no 2560 0.227528176407325 846 603940 SGTC_1908 st060353 56.5 µM -0.747595664242083 0.23692620198586 no 2561 0.227352040376247 872 4227716 SGTC_2492 derrusnin 100 µM -0.747624995127975 0.236917688301967 no 2562 0.227343191929356 864 1715307 Part of coumarin class of compounds. SGTC_3334 9142812 21.919 µM -0.748869804572694 0.236556520700693 no 2563 0.226967840739719 848 45283678 SGTC_344 k064-0035 6.43 µM -0.75002868614208 0.236220556609859 no 2564 0.226618713998631 837 5088750 SGTC_3150 9097574 49.47 µM -0.751544621250303 0.235781478350843 no 2565 0.226162478607011 832 17217476 SGTC_2771 fluoxetine 41.05 µM -0.751565841237125 0.235775335349745 no 2566 0.226156095931643 857 3386 A selective serotonin reuptake inhibitor. SGTC_2049 5262831 67.185 µM -0.754150934305495 0.235027634031839 no 2567 0.225379297995825 864 763417 SGTC_3300 9124615 50.48 µM -0.754292996972302 0.234986582437329 no 2568 0.225336653237974 852 24824903 SGTC_153 4077-0274 519.67 µM -0.754535289680623 0.234916576688523 no 2569 0.225263931696307 847 3121976 SGTC_2821 7996764 71.43 µM -0.756264054853803 0.23441741836395 no 2570 0.22474544739981 808 2987135 SGTC_3147 9097027 49.47 µM -0.757824584630436 0.233967340259895 no 2571 0.224278001315008 887 25236841 SGTC_2342 7990637 118.86 µM -0.757855045765296 0.233958559618508 no 2572 0.224268882384957 867 2033102 YER133W GLC7 SGTC_2907 7721985 69.9 µM -0.758146771028395 0.233874476958276 no 2573 0.224181561361159 844 3267881 SGTC_3342 9147791 14.508 µM -0.758316233815484 0.23382564115109 no 2574 0.224130845570336 851 1838168 SGTC_1203 3992-3522 103 µM -0.7603563676353 0.233238158887196 no 2575 0.223520798409391 863 5322312 SGTC_1015 4130-4525 82 µM -0.761510017356236 0.23290631385094 no 2576 0.223176248950265 863 1363237 SGTC_1964 st076914 61 µM -0.763314185243003 0.232387874769141 no 2577 0.222638022133503 888 24208661 SGTC_1814 st052110 31.539 µM -0.763752436308614 0.232262037517644 no 2578 0.222507393053012 854 674163 SGTC_3227 9130768 49.47 µM -0.763912001351985 0.232216230214419 no 2579 0.22245984250701 876 17720899 SGTC_2407 paclitaxel 400 µM -0.764439673870608 0.232064783877181 no 2580 0.222302636833877 892 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_784 4579-0127 173 µM -0.764636807151543 0.232008219121265 no 2581 0.222243922601415 871 1948547 SGTC_1648 st011736 69.8 µM -0.765512989659677 0.231756903186265 no 2582 0.221983067244588 864 2855514 SGTC_629 3448-6466 76.7 µM -0.767500147816336 0.231187487922936 no 2583 0.221392102670045 870 573744 SGTC_2623 humulene 100 µM -0.76798890545493 0.231047555330411 no 2584 0.221246888109931 864 6187145 An anti-inflammatory. SGTC_1737 st035557 69.7 µM -0.769552783673779 0.230600130681945 no 2585 0.220782611195629 857 5716916 SGTC_583 1488-1091 88.9 µM -0.770717349646101 0.230267263786138 no 2586 0.220437242968108 886 4303273 SGTC_1327 1436-0082 2.18 µM -0.772824052102435 0.229665790130035 no 2587 0.219813258441008 872 15992205 SGTC_644 1498-1197 63.3 µM -0.772881188907394 0.229649489564499 no 2588 0.219796349215527 872 6741615 SGTC_3027 9089541 49.47 µM -0.773116760672621 0.229582290113364 no 2589 0.219726641335971 872 9943819 SGTC_2457 5731572 11.68 µM -0.773304149532891 0.229528843236584 no 2590 0.219671200291925 857 2865357 SGTC_2268 7933382 153.85 µM -0.773917263562097 0.229354020153178 no 2591 0.2194898599451 867 935025 YOR257W CDC31 SGTC_648 0375-0473 33.3 µM -0.775386384924409 0.228935419350492 no 2592 0.219055688932478 869 1713139 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.776241944502764 0.228691840071132 no 2593 0.218803072217858 860 1609 A potent and irreversible inhibitor of serine proteases. SGTC_699 0375-0592 111 µM -0.776710535552559 0.228558493096489 no 2594 0.218664784806065 821 762578 SGTC_812 4251-0442 148 µM -0.77709563438644 0.228448938207104 no 2595 0.218551174721452 880 5723007 SGTC_3032 9089427 49.47 µM -0.778486137023943 0.228053606589993 no 2596 0.218141238055491 829 17173707 SGTC_2164 5685496 200 µM -0.778686517179275 0.227996668558236 no 2597 0.218082200163743 883 759046 SGTC_1163 k060-0048 49.9 µM -0.780660048352517 0.227436316956178 no 2598 0.217501232046245 857 6809982 SGTC_1636 st007707 68.9 µM -0.780674217506527 0.227432296665531 no 2599 0.217497064163259 881 403051 SGTC_2970 9090938 41.86 µM -0.780992499831038 0.227341999251001 no 2600 0.217403452975847 854 17217104 SGTC_2905 7799065 20.05 µM -0.781189579927847 0.227286097309611 no 2601 0.217345500685677 843 1296806 SGTC_1228 0124-0032 52.5 µM -0.782747714259577 0.226844403944544 no 2602 0.216887638429437 855 X1228 SGTC_1464 k208-0027 110 µM -0.783396358361651 0.226660671887593 no 2603 0.216697196990463 855 X1464 SGTC_19 0279-0214 38.434 µM -0.784212319550422 0.226429665657421 no 2604 0.216457768779547 866 3566274 YBR002C RER2 SGTC_311 1315-0136 58 µM -0.785139410629154 0.226167358939063 no 2605 0.216185917497876 862 6759207 SGTC_2687 chenodiol 100 µM -0.786279157133024 0.225845119945579 no 2606 0.21585198026215 851 5702181 A cholesterol synthesis inhibitor. SGTC_2942 9052777 62.25 µM -0.786401993932567 0.225810405969323 no 2607 0.215816007848488 888 6469503 SGTC_216 k038-0035 28.382 µM -0.786578802251752 0.22576044480972 no 2608 0.215764236126301 861 4444231 YPR107C YTH1 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.786580594115283 0.225759938510463 no 2609 0.215763711482745 865 1241132 A phosphatase inhibitor. SGTC_435 c-PAF 6.7 µM -0.788101548469463 0.225330417591263 no 2610 0.215318654764713 850 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_542 3381-0244 89.3 µM -0.788693970588776 0.225163241562234 no 2611 0.215145446386534 880 1112843 SGTC_979 1426-2828 121 µM -0.790692733476328 0.224599727937834 no 2612 0.214561658726457 874 747872 SGTC_2202 7226349 200 µM -0.790705288519622 0.224596190809736 no 2613 0.214557994631199 858 844334 SGTC_1467 k284-1082 293 µM -0.793566994637032 0.223790788226437 no 2614 0.213723776616436 870 3334705 SGTC_2931 9014674 55.67 µM -0.793661982282702 0.223764082951251 no 2615 0.213696119133386 887 2996810 SGTC_2676 harmalol 100 µM -0.794370386196436 0.223564976074182 no 2616 0.213489919449343 852 5459187 A monoamine oxidase inhibitor SGTC_2376 9072922 81.32 µM -0.794423725288583 0.223549988452812 no 2617 0.213474398392249 872 17087968 SGTC_2868 9035608 32.47 µM -0.795671724236558 0.223199479421684 no 2618 0.213111432921965 867 6462614 SGTC_408 cantharidin 100 µM -0.797970788786201 0.22255459116263 no 2619 0.212443720930131 862 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3275 9138069 49.47 µM -0.799897573192614 0.222014946818136 no 2620 0.211885071979945 870 17617007 SGTC_2453 5731132 22.18 µM -0.800213508921965 0.221926532431481 no 2621 0.211793552134792 881 1362040 SGTC_647 0140-0236 81 µM -0.800760243330367 0.221773576714478 no 2622 0.211635229493378 872 990837 SGTC_1502 4534-4282 27.7 µM -0.801879791822244 0.221460557159847 no 2623 0.211311248350346 883 3278949 SGTC_1555 citronellol 128 µM -0.802954435615494 0.221160330440995 no 2624 0.211000535439996 857 8842 A terpine precursor. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.803302390955825 0.221063170957279 no 2625 0.210899988168501 859 6708739 YPR165W RHO1 SGTC_86 0417-1630 471.922 µM -0.80342650102669 0.221028521643746 no 2626 0.210864131373453 863 3634867 SGTC_3341 9147222 25.867 µM -0.803437441368794 0.221025467444846 no 2627 0.210860970757066 868 1939759 SGTC_822 1487-0950 154 µM -0.804508143510038 0.220726678007735 no 2628 0.210551784075038 859 1958375 SGTC_160 3453-0671 289.699 µM -0.805064332063284 0.220571559735749 no 2629 0.210391278547849 882 5322268 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.806138486650283 0.220272160123799 no 2630 0.210081501191226 883 7104 SGTC_1699 st031318 29.054 µM -0.806310156809987 0.220224332024924 no 2631 0.210032017774516 865 5340658 SGTC_3067 9117431 49.47 µM -0.806320301622682 0.220221505819649 no 2632 0.210029093776532 905 17150885 SGTC_3072 9116419 49.47 µM -0.808478480886641 0.219620739779216 no 2633 0.209407594515094 871 17170162 SGTC_2012 4023501 200 µM -0.808823538598296 0.219524774419473 no 2634 0.209308327343266 883 3477460 SGTC_1281 0884-0031 11.8 µM -0.809854847357368 0.219238096697431 no 2635 0.209011802678497 879 1548255 SGTC_524 r073-0010 27.8 µM -0.810785131329031 0.218979686013875 no 2636 0.208744537298523 881 2772106 SGTC_658 3253-0951 102 µM -0.811263615170607 0.218846842877839 no 2637 0.208607150040662 883 1184878 SGTC_874 0599-0792 117 µM -0.81237210732506 0.21853926653793 no 2638 0.20828907310778 870 765305 SGTC_2017 5132927 60.65 µM -0.812495363858414 0.218505081595057 no 2639 0.208253722874209 869 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_176 1486-1328 72.834 µM -0.813105640483519 0.218335868016664 no 2640 0.208078746410547 870 22310231 SGTC_253 dyclonine 31.25 µM -0.81612743510445 0.217499117318295 no 2641 0.20721362706755 863 3180 An oral anasthetic. SGTC_225 nsc-122657 1.016 µM -0.818306796674114 0.216896791357282 no 2642 0.206591013064656 881 275685 SGTC_1109 tnp00067 928.257 nM -0.818811172085979 0.216757530994106 no 2643 0.206447077905655 877 676295 SGTC_1428 4049-0204 61.7 µM -0.818831659271931 0.216751875481116 no 2644 0.206441232670496 889 X1428 SGTC_76 0433-0009 400.328 µM -0.820449147818378 0.216305635151913 no 2645 0.205980053704246 917 2841569 SGTC_531 3788-1495 174 µM -0.820795609767808 0.216210120809002 no 2646 0.205881349857538 854 2896655 SGTC_2665 lovastatin 100 µM -0.821932359875357 0.215896907484597 no 2647 0.205557697250908 873 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1331 1472-0049 76.2 µM -0.822164473127553 0.215832984727131 no 2648 0.205491647710341 880 24051409 SGTC_248 streptozotocin 5.23457 mM -0.822718151268871 0.215680549002315 no 2649 0.205334145396026 883 5300 DNA alkylating agent. SGTC_2431 5490079 200 µM -0.823394403671481 0.215494451483545 no 2650 0.205141872244403 899 5722345 SGTC_2923 7992654 58.14 µM -0.823793827908727 0.215384577916412 no 2651 0.20502835759092 853 2985126 SGTC_799 1310-0557 151 µM -0.823856283450654 0.215367400592936 no 2652 0.20501061137013 887 5354492 SGTC_1572 epiandrosterone 68.9 µM -0.826200784091891 0.214723161132573 no 2653 0.204345101768831 868 441302 A steroid. SGTC_2742 clothiapine 36.27 µM -0.827866212298112 0.214266203352563 no 2654 0.203873135850068 857 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_102 gallobenzophenone 83.616 µM -0.828697266216045 0.214038391718934 no 2655 0.203637866550438 858 70837 SGTC_2823 7987624 58.44 µM -0.830287910843422 0.213602751579669 no 2656 0.203188010746477 880 2239440 SGTC_2227 7312221 64.1025 µM -0.830568337253683 0.213526002985855 no 2657 0.203108763919825 900 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_27 0485-0001 32.618 µM -0.831240406839643 0.213342132821598 no 2658 0.202918916193788 861 2054479 SGTC_48 0382-0018 55 µM -0.831629044049445 0.213235848486749 no 2659 0.202809181464724 876 762596 SGTC_1386 3228-0095 33.8 µM -0.834746784936285 0.212384328166082 no 2660 0.201930146885385 881 870181 SGTC_1352 1496-0991 99 µM -0.837159800872391 0.21172664912459 no 2661 0.201251375003223 895 3000039 SGTC_2847 9005661 71.43 µM -0.838647816337378 0.211321678186186 no 2662 0.20083348483124 853 2991449 SGTC_504 lovastatin 124 µM -0.839444843384531 0.211104949981789 no 2663 0.200609864267978 886 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2517 totarol 10 µM -0.840291135076657 0.210874968356866 no 2664 0.200372585323902 864 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_3054 9094397 49.47 µM -0.841067062207317 0.210664237617934 no 2665 0.200155183057867 893 2598354 SGTC_937 3122-0005 46.7 µM -0.841333935040794 0.210591787327959 no 2666 0.200080442372628 867 759535 SGTC_3337 9144342 33.5465 µM -0.842730094779426 0.210212998092823 no 2667 0.199689705962863 864 17682949 SGTC_162 k030-0015 37.8 µM -0.843505989018212 0.210002664912056 no 2668 0.199472758837067 910 1809920 YMR134W ERG29 SGTC_526 4469-0568 170 µM -0.844147343916924 0.209828896703522 no 2669 0.199293537294562 882 2901964 SGTC_1983 st071813 46.9 µM -0.844839052230649 0.209641580549471 no 2670 0.199100353616703 886 11838595 SGTC_2569 tetrandrine 100 µM -0.845191893878625 0.209546068132757 no 2671 0.199001853743841 874 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1265 0819-1001 68.8 µM -0.846857230983585 0.209095615591744 no 2672 0.198537351912341 892 3106768 SGTC_1141 3253-0389 52.6 µM -0.849573996906474 0.208361989991187 no 2673 0.197780986983678 896 5402031 SGTC_417 st075190 100 µM -0.851659326496092 0.207799906520304 no 2674 0.197201600786512 891 222757 SGTC_2235 salicylic acid 500 µM -0.853126704961352 0.207404924056528 no 2675 0.196794521796052 883 338 A COX inhibitor and kinase inhibitor. SGTC_2277 7947813 106.88 µM -0.853197388972524 0.207385908857505 no 2676 0.19677492554795 907 1246798 SGTC_1863 st057641 20.1 µM -0.853504181617203 0.207303388373029 no 2677 0.196689884863783 905 3921635 SGTC_3201 9113999 49.47 µM -0.856160157276892 0.206589801246476 no 2678 0.195954598734521 900 16649224 SGTC_712 r015-0009 80.6 µM -0.857560989814507 0.206214023069602 no 2679 0.19556746181317 902 6813872 YLR060W FRS1 SGTC_1085 doxorubicin 7.67 µM -0.85784363873977 0.206138250672441 no 2680 0.195489404728269 882 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_591 4299-0174 154 µM -0.858043627654023 0.206084647707419 no 2681 0.195434186685383 900 5509088 SGTC_2976 9009005 19.48 µM -0.860069623349829 0.205542086864325 no 2682 0.194875332360667 846 2993148 SGTC_403 arphamenine a 50 µM -0.862774307202599 0.204819096906154 no 2683 0.194130784008114 894 5487158 An arginine aminopeptidase inhibitor. SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.862795871976886 0.20481333850295 no 2684 0.194124854604868 896 5282309 SGTC_1513 0337-0559 19 µM -0.863560843097888 0.204609131919839 no 2685 0.193914591189217 892 775073 SGTC_2117 5521686 200 µM -0.864707129942724 0.204303361197148 no 2686 0.193599777548664 907 803312 SGTC_1547 harmine 94.2 µM -0.867362790459322 0.203596012861182 no 2687 0.192871631385172 880 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.867510497581716 0.203556713259877 no 2688 0.19283118126108 889 15053 SGTC_25 0118-0223 35.662 µM -0.868901245755114 0.203186906632201 no 2689 0.192450574063923 878 5333628 SGTC_337 1315-0038 354 µM -0.868940165228301 0.203176563528796 no 2690 0.192439929550456 884 1626437 SGTC_2081 5214970 32.255 µM -0.869000255007127 0.203160594896065 no 2691 0.192423495644921 901 2063512 SGTC_2319 6033012 152.6 µM -0.871498155379492 0.202497450371594 no 2692 0.191741106307413 907 847246 SGTC_2667 digitoxin 100 µM -0.872590374624851 0.202207894270308 no 2693 0.191443194419357 848 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_696 1560-0013 611 µM -0.873777333051495 0.201893503075692 no 2694 0.191119763418522 880 1650269 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.874303366437794 0.201754265575976 no 2695 0.190976533253726 895 676296 Flavone; oxidizing agent. SGTC_970 1315-0089 19.5 µM -0.874889462623536 0.201599197607052 no 2696 0.190817026552568 878 6811083 YLR033W RSC58 SGTC_2895 9054447 58.44 µM -0.875796834778603 0.201359268072647 no 2697 0.19057024554729 912 2697450 SGTC_3211 9128781 49.47 µM -0.876072268357009 0.201286471137959 no 2698 0.190495373748493 902 17194361 SGTC_2311 7694451 200 µM -0.876583802021066 0.201151314955977 no 2699 0.190356370201708 890 2163142 SGTC_2740 felodipine 17.08 µM -0.878611285957314 0.200616153640917 no 2700 0.189806037192744 861 3333 L-type calcium channel blocker SGTC_2838 9002687 71.43 µM -0.878655104959718 0.200604596910843 no 2701 0.189794153930346 904 6457060 SGTC_1385 3091-4834 14.1 µM -0.879327398701983 0.2004273377127 no 2702 0.189611892148832 891 4072814 SGTC_1212 0520-0165 585 µM -0.883786516355905 0.199254015249292 no 2703 0.188405733235576 928 5403258 SGTC_1157 4092-0394 27.6 µM -0.883796088676075 0.199251500953671 no 2704 0.188403149093541 901 3659885 SGTC_776 4476-4378 112 µM -0.884120680995467 0.199166253827398 no 2705 0.188315535142317 925 2892008 SGTC_2793 7325131 81.82 µM -0.886349592315515 0.198581472268649 no 2706 0.187714586578595 880 4176441 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.886778680675616 0.198469014792962 no 2707 0.187599033919794 904 6708760 SGTC_317 4495-0002 170 µM -0.889906622828114 0.19765039064846 no 2708 0.186758013739376 893 15991618 SGTC_1149 3909-7961 23.3 µM -0.891379998697532 0.197265496649521 no 2709 0.186362672119637 902 735261 SGTC_928 2764-0428 58.7 µM -0.891646105112777 0.197196029316127 no 2710 0.186291324784688 911 662578 SGTC_244 nsc-207895 1.295 µM -0.891839673713855 0.197145507348345 no 2711 0.186239436618455 856 42640 SGTC_1452 4194-0072 190 µM -0.892303155563471 0.197024569070394 no 2712 0.186115231673223 917 1343545 SGTC_3164 9100705 49.47 µM -0.892581420954918 0.196951981682991 no 2713 0.186040686137904 864 17174235 SGTC_810 3825-7150 143 µM -0.893362193203762 0.196748398476641 no 2714 0.185831621049753 865 22330411 YGL099W LSG1 SGTC_3323 9138564 53.9225 µM -0.894023921381871 0.196575955350537 no 2715 0.185654546170928 900 43912313 YNL103W MET4 SGTC_2275 7947463 200 µM -0.895434353574947 0.196208709339344 no 2716 0.185277471666706 876 1225414 SGTC_2677 mitomycin C 100 µM -0.896786988923915 0.195856903455123 no 2717 0.184916296031873 927 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_777 1315-0167 517 µM -0.898195972481325 0.195490849333245 no 2718 0.184540540100519 883 4221767 SGTC_1796 st049173 110.4 µM -0.899022245142539 0.19527637698953 no 2719 0.184320405954871 903 94134 SGTC_1527 coumarin 137 µM -0.902106908225576 0.194476967085988 no 2720 0.183500039749466 931 323 A hepatotoxic, DNA x-linker. SGTC_1810 st050138 53 µM -0.90299887562421 0.194246179902793 no 2721 0.183263245839985 917 3444541 SGTC_442 cape 100 µM -0.903629549328017 0.194083100415507 no 2722 0.183095933594572 898 5281787 SGTC_2810 7959871 45.46 µM -0.90499591398519 0.193730072319689 no 2723 0.18273377593114 887 2974535 SGTC_2304 7443016 91.4 µM -0.905447689785906 0.193613433031797 no 2724 0.182614130305911 915 939854 SGTC_3214 9129694 49.47 µM -0.906584742702737 0.193320058775526 no 2725 0.182313216519899 919 17158655 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.907517088357209 0.193079704148895 no 2726 0.182066708531928 904 688788 SGTC_2136 5328288 199.296 µM -0.907586870773971 0.193061721889464 no 2727 0.182048266761235 915 262395 SGTC_2306 7482397 179.52 µM -0.908941667847397 0.192712806353396 no 2728 0.181690458799499 955 891448 SGTC_2464 5717415 7.67 µM -0.913703928389123 0.191489390692535 no 2729 0.180436219635794 895 5285744 SGTC_2449 5812982 45.77 µM -0.916108733096435 0.190873413203474 no 2730 0.179804933889375 916 776185 SGTC_2551 apiole 73.87 µM -0.916903237407114 0.190670172750653 no 2731 0.179596673688488 881 10659 A possible DNA adduct former. SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.917297166709147 0.190569451810508 no 2732 0.179493470831961 892 3256 An antibiotic and ribosome inhibitor. SGTC_1020 4335-0961 93.3 µM -0.917570567073655 0.190499567249735 no 2733 0.179421866449921 925 669075 SGTC_3270 9137563 49.47 µM -0.919992913034902 0.189881072806537 no 2734 0.178788231347306 872 17015724 SGTC_2588 indole-3-carbinol 100 µM -0.922089882781582 0.18934665447028 no 2735 0.17824084688344 910 3712 Induces cell cycle arrest. SGTC_2259 7964009 200 µM -0.926659550621909 0.1881852736541 no 2736 0.177051662653063 900 313134 SGTC_592 k241-0073 46.5 µM -0.927734516882804 0.187912711034228 no 2737 0.176772649522072 902 4230158 SGTC_669 0108-0021 26.2 µM -0.927737473859762 0.187911961615508 no 2738 0.176771882406742 910 17201 SGTC_737 1950-0117 57.9 µM -0.92869353052425 0.18766975457593 no 2739 0.176523967235542 909 5393513 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.929281703816297 0.187520842840259 no 2740 0.176371557261552 910 2374 Ca(2+)-ATPase inhibitor. SGTC_2005 4024620 188 µM -0.930793334105815 0.187138468470369 no 2741 0.175980239245407 916 236743 SGTC_3329 9141233 27.5565 µM -0.932566074335287 0.186690659907011 no 2742 0.175522028283058 905 4909101 YNL103W MET4 SGTC_1108 betulinic acid 729.144 nM -0.933467653074585 0.18646316850373 no 2743 0.175289282078332 889 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2185 6113692 200 µM -0.93414447485483 0.186292501915019 no 2744 0.175114686455955 918 874150 SGTC_2109 5483026 200 µM -0.936197066881172 0.185775514822711 no 2745 0.174585866547618 921 759335 SGTC_2132 5317594 122.667 µM -0.937617719943103 0.185418216081068 no 2746 0.174220450824739 920 794577 SGTC_742 0kpi-0133 140 µM -0.938119430642634 0.185292136245437 no 2747 0.174091518662608 922 2728852 SGTC_2108 5365811 200 µM -0.939667236983912 0.184903508255492 no 2748 0.173694137847623 902 780283 SGTC_569 4130-2812 160 µM -0.944646117955041 0.183656834369806 no 2749 0.172419787000423 910 743552 SGTC_1782 st039423 80.636 µM -0.945528256290642 0.18343650106707 no 2750 0.172194626056123 928 2068169 SGTC_1743 st037606 46.3785 µM -0.946028897395469 0.183311528352453 no 2751 0.172066923676898 903 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_204 PMA1.184 62.41 µM -0.947676416798191 0.182900640683288 no 2752 0.17164710515745 918 2252213 YGL008C PMA1 SGTC_909 3448-9333 149 µM -0.948212724734505 0.182767010781833 no 2753 0.17151058524058 927 3344074 SGTC_849 0386-0493 241 µM -0.948365754184205 0.182728892168894 no 2754 0.171471643542351 918 726119 SGTC_189 3970-0742 2.116 µM -0.949579851174184 0.182426644650151 no 2755 0.171162890225136 901 2891807 SGTC_3037 9091026 49.47 µM -0.949707442489823 0.182394899140572 no 2756 0.171130463522199 913 25236398 YIL048W NEO1 SGTC_627 1391-0720 175 µM -0.951718071985175 0.181895097876431 no 2757 0.170619990795751 944 997839 SGTC_1581 himbacine 57.9 µM -0.953269751494271 0.181509968343845 no 2758 0.170226706673089 937 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1245 0418-0076 17.2 µM -0.95383097015013 0.181370798685062 no 2759 0.170084604985547 951 6790114 SGTC_585 0kpi-0023 191 µM -0.955594317739906 0.180933962863323 no 2760 0.169638616711562 879 64601 SGTC_2244 6635614 200 µM -0.955841836004172 0.180872697736862 no 2761 0.169576074149394 929 836499 SGTC_422 cantharidin 155 µM -0.958449496938168 0.180228046019335 no 2762 0.16891807316048 930 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3255 9139072 49.47 µM -0.96065682861378 0.179683489938461 no 2763 0.168362372375412 906 17646060 SGTC_483 fpl-64176 144 µM -0.961105898021373 0.179572829708928 no 2764 0.168249462218898 930 3423 SGTC_2355 9061122 103.12 µM -0.963789898089368 0.178912328482294 no 2765 0.167575636170033 950 5302957 SGTC_841 0251-0215 91.2 µM -0.963992552533986 0.178862519735453 no 2766 0.167524829857726 925 3888614 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.964097434814766 0.178836745021575 no 2767 0.167498539330898 925 641818 YHR062C RPP1 SGTC_2340 7987427 183.45 µM -0.965821785966615 0.178413322713559 no 2768 0.167066682532426 909 2239331 SGTC_374 0880-0231 82.3 µM -0.966061278372249 0.178354564250394 no 2769 0.167006759457688 908 6833587 SGTC_2913 7966556 36.57 µM -0.966167161700782 0.178328590104679 no 2770 0.166980270950778 873 2976516 SGTC_3038 9091290 49.47 µM -0.969172319310446 0.177592391564939 no 2771 0.166229609783735 913 25236843 SGTC_2090 5301565 104.445 µM -0.969927998573087 0.177407568731807 no 2772 0.166041191436777 924 2056344 SGTC_64 000l-0018 272.079 µM -0.970712754222995 0.177215763024022 no 2773 0.165845669409574 916 6811119 SGTC_430 0958-0115 16.4 µM -0.970965316344762 0.177154061032778 no 2774 0.165782775175228 921 6833180 SGTC_205 1486-1330 71.903 µM -0.971147436707965 0.17710957668179 no 2775 0.165737432255999 931 4118834 SGTC_2334 9017922 200 µM -0.974003629546923 0.176412852127719 no 2776 0.165027368540313 924 3163164 SGTC_473 2-arachidonoylglycerol 10 µM -0.974154391815687 0.17637612421957 no 2777 0.164989943098919 899 5282280 An endocannabinoid. SGTC_1411 3909-8223 150 µM -0.974324986387993 0.176334570704973 no 2778 0.164947601086267 918 X1411 SGTC_416 estradiol valerate 100 µM -0.974500083895326 0.176291926805441 no 2779 0.164904148751887 930 13791 A steroid. SGTC_3268 9137683 49.47 µM -0.974797595413523 0.176219484706964 no 2780 0.164830335061046 977 1953228 SGTC_587 k089-0003 57 µM -0.974991633689099 0.176172247814756 no 2781 0.164782204990533 890 9659696 SGTC_2234 tolnaftate 200 µM -0.975124352764518 0.176139943152432 no 2782 0.164749290035948 945 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1534 6-azauridine 81.6 µM -0.975690511017317 0.176002178771079 no 2783 0.164608927969266 914 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_2077 5212015 200 µM -0.975776258009526 0.175981319740238 no 2784 0.164587676316765 909 780900 SGTC_1059 3448-6867 171 µM -0.977047281292225 0.175672310979101 no 2785 0.164272872676211 909 3934407 SGTC_3149 9097855 49.47 µM -0.979961067476035 0.174965215193861 no 2786 0.163552668427407 885 25236625 YMR079W SEC14 SGTC_751 0833-0568 350 µM -0.980978829955411 0.174718658384824 no 2787 0.163301590676937 926 6954252 SGTC_2401 5128683 200 µM -0.982598019018815 0.174326858556183 no 2788 0.162902659891254 947 708373 SGTC_1263 0774-1208 64.8 µM -0.983109964788602 0.174203097807479 no 2789 0.162776660234501 927 906585 SGTC_2948 9070189 9.45 µM -0.984842376635645 0.173784708804228 no 2790 0.162350750787313 869 6473636 YDL196W YDL196W SGTC_2294 7971431 200 µM -0.985803730790872 0.173552811356227 no 2791 0.162114717327351 962 5741572 SGTC_1716 st033144 30.6155 µM -0.986140183757778 0.173471698852294 no 2792 0.162032163586604 924 674617 SGTC_1977 st070720 65.3 µM -0.986298077811203 0.173433641875413 no 2793 0.161993431373259 916 682188 SGTC_431 k089-0097 107 µM -0.987931678448487 0.173040209432583 no 2794 0.16159305485094 899 5499420 SGTC_481 bay k-8644 50 µM -0.988183598029286 0.172979588366033 no 2795 0.16153136974967 929 2303 A calcium channel antagonist. SGTC_501 nsc-95397 161 µM -0.992321748925131 0.171985735028923 no 2796 0.160520298594202 922 262093 SGTC_1578 josamycin 24.2 µM -0.992837911418846 0.171862025290499 no 2797 0.16039447564758 920 5282165 A P450 substrate. SGTC_1594 piperine 70.1 µM -0.995687838663022 0.171180000671185 no 2798 0.159700920418229 926 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1763 st044482 94.5 µM -0.996842899413953 0.170904073191179 no 2799 0.159420385741117 923 88505 SGTC_951 1171-0579 82.7 µM -0.998291587313572 0.170558404910099 no 2800 0.159068992903618 916 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_706 4262-0057 46.9 µM -1.00040371245117 0.170055237997654 no 2801 0.158557587055797 949 883298 SGTC_2383 9036125 200 µM -1.00096873726056 0.169920794847044 no 2802 0.158420961413573 937 79580 SGTC_2140 5586273 200 µM -1.00184822067687 0.169711664397957 no 2803 0.158208451911246 928 854421 SGTC_2883 9059145 45.46 µM -1.00341234234971 0.169340143361565 no 2804 0.157830975741334 954 16476510 SGTC_6 0844-0013 19.835 µM -1.00545203532137 0.168856446201366 no 2805 0.15733961722913 950 1584900 SGTC_2950 9072895 21.46 µM -1.01326001217573 0.167013058302312 no 2806 0.155467991161389 907 17332245 SGTC_1596 piperlongumine 63 µM -1.01404355230627 0.166828791238427 no 2807 0.155280985520843 929 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3110 9122132 49.47 µM -1.01635393447061 0.166286216826199 no 2808 0.154730436798283 929 918317 SGTC_1319 1306-0155 43.7 µM -1.01640049127492 0.166275295067094 no 2809 0.154719355893772 936 3122360 SGTC_1965 Pectolinarigenin 58.4 µM -1.01685953975728 0.166167631704701 no 2810 0.154610126630795 941 5320438 An anti-inflammatory. SGTC_3061 glucosamine 200 µM -1.01759238268786 0.165995847060148 no 2811 0.154435854414979 904 91431 and experimental redox chemotherapeutic SGTC_2585 alliin 100 µM -1.01890590038175 0.165688234579588 no 2812 0.154123821121447 939 87310 A garlic compound which reacts with lipids. SGTC_1788 fluconazole 20 µM -1.01925156788939 0.165607344068098 no 2813 0.154041775283843 909 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1368 1852-0141 284 µM -1.02462239818238 0.164353784800941 no 2814 0.152770695916614 940 2838987 SGTC_3115 9123671 49.47 µM -1.02469127520331 0.164337748864263 no 2815 0.15275444054753 951 3286988 SGTC_1882 5615643 20 µM -1.0261963888869 0.163987581843585 no 2816 0.152399511587478 894 2253075 SGTC_619 1652-1634 108 µM -1.02625924175895 0.163972969563361 no 2817 0.152384701828805 954 5400454 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.02657245749715 0.163900164544887 no 2818 0.152310914359 941 6708784 An antioxidant flavonoid SGTC_2065 5221596 34.26 µM -1.026622118083 0.163888623182507 no 2819 0.152299217480066 925 788581 SGTC_2580 diallyl disulphide 81.36 µM -1.02717699279312 0.163759703461523 no 2820 0.152168564805925 925 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_695 3505-6186 243 µM -1.0309561811052 0.162883397459165 no 2821 0.151280684436316 940 1819379 SGTC_3101 9120531 49.47 µM -1.03139349976419 0.162782190611862 no 2822 0.15117816393231 956 24824904 SGTC_3120 9124077 49.47 µM -1.03320787291728 0.162362734666807 no 2823 0.150753314665733 969 18774327 YGL155W CDC43 SGTC_46 0329-0187a 2.197 µM -1.03326604086306 0.162349298756654 no 2824 0.150739707363119 924 46494817 SGTC_2394 5221648 200 µM -1.03401835787973 0.162175590189744 no 2825 0.150563790560641 948 788586 SGTC_3250 9135583 49.47 µM -1.03440901005697 0.162085437101065 no 2826 0.15047249701538 938 7699353 SGTC_1753 st043925 64 µM -1.03618515174676 0.16167595811764 no 2827 0.150057886254697 951 670181 SGTC_1999 st074831 12.5 µM -1.03823969716098 0.161203136611708 no 2828 0.149579237726617 939 17112523 SGTC_1518 st038567 90.8 µM -1.0383571124579 0.16117614259482 no 2829 0.14955191423381 946 77966 SGTC_1526 st051518 75 µM -1.03878184468067 0.161078520418864 no 2830 0.149453103415804 942 673993 SGTC_213 1246-0773 967 nM -1.03961693785808 0.160886691753801 no 2831 0.149258952244323 940 6251622 SGTC_105 0111-0055 734.78 µM -1.03989123542438 0.160823715603742 no 2832 0.14919521744509 956 5179370 SGTC_1191 1487-1166 10.6 µM -1.04157635554843 0.16043718101521 no 2833 0.148804067807902 981 3955771 SGTC_348 k064-0012 10.7 µM -1.04282022938422 0.160152249680957 no 2834 0.148515780182257 928 5066323 SGTC_2186 6124449 200 µM -1.04463729334291 0.159736613971196 no 2835 0.148095318276164 933 3834182 YLR033W RSC58 SGTC_765 1319-0117 244 µM -1.04602740608654 0.15941911612821 no 2836 0.147774189650158 906 3487746 YGL099W LSG1 SGTC_942 3253-1115 227 µM -1.04647492272758 0.159316992558806 no 2837 0.147670908545547 945 46497897 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.04716710441617 0.159159120667968 no 2838 0.14751125712318 939 551469 SGTC_2564 betulinic acid 100 µM -1.04961034605987 0.158602688825256 no 2839 0.146948649182112 980 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2126 5251174 33.877 µM -1.05106653107185 0.158271659932671 no 2840 0.146614017206561 944 790722 SGTC_1249 0481-0015 10.2 µM -1.05324890247525 0.157776399368915 no 2841 0.146113465490688 934 4227577 SGTC_762 1165-0429 115 µM -1.05547274625281 0.157272775416368 no 2842 0.145604583815216 935 5967793 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.05595158785564 0.157164472741693 no 2843 0.145495166709435 976 4620898 SGTC_191 3914-0123 66.505 µM -1.05685582509658 0.156960089391984 no 2844 0.145288695942923 964 3144412 SGTC_78 0336-0123 156.75 µM -1.05689106404644 0.156952127927895 no 2845 0.145280653581665 928 6765896 SGTC_2507 purpurin 79.67 µM -1.05778492691124 0.156750268151835 no 2846 0.145076753103901 948 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1794 st048918 76.9 µM -1.05788593589265 0.156727468187183 no 2847 0.14505372390324 873 672303 SGTC_2678 equilin 100 µM -1.06053404777647 0.156130509402687 no 2848 0.144450854396014 892 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.06114782061293 0.155992361921767 no 2849 0.144311364159252 953 6710655 SGTC_1973 st070275 50.2 µM -1.06333454286182 0.155500831320184 no 2850 0.143815132764346 937 17118334 SGTC_1618 st003135 44.5 µM -1.06342287028312 0.15548099860935 no 2851 0.143795112901233 952 1270615 SGTC_2197 6588183 93.1375 µM -1.06724648442283 0.154624058306599 no 2852 0.142930273414014 930 884136 SGTC_941 3237-0776 460 µM -1.0683772296471 0.154371237226126 no 2853 0.142675192047637 952 760008 SGTC_2229 7354935 190 µM -1.07018191759883 0.153968297158582 no 2854 0.142268715977639 947 318112 SGTC_465 cgp-37157 41 µM -1.07026982281772 0.15394868799167 no 2855 0.142248936816096 915 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2800 7887935 81.82 µM -1.07168254911332 0.153633775428722 no 2856 0.141931320804315 977 2961002 SGTC_1435 4092-0789 56.7 µM -1.07365074732897 0.153195753476745 no 2857 0.141489621910651 935 2248285 SGTC_3078 9116413 49.47 µM -1.07535547982033 0.152817035223308 no 2858 0.14110780297881 942 17177322 SGTC_1927 st060202 13.8 µM -1.07709665812389 0.152430861752156 no 2859 0.140718542955773 920 688887 SGTC_2372 9071633 200 µM -1.08348963577029 0.151018531052764 no 2860 0.139295574352979 956 21321366 SGTC_1569 carminic acid 40.6 µM -1.08372492138901 0.150966718655522 no 2861 0.139243391222327 942 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_608 k048-0125 159 µM -1.08491995650264 0.150703741867016 no 2862 0.138978554167565 950 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.08636137642878 0.150386952267032 no 2863 0.138659571227967 965 803109 SGTC_3187 9109394 49.47 µM -1.08929251216813 0.149744128177665 no 2864 0.138012456854901 938 17098090 SGTC_2875 9039966 71.43 µM -1.08972128195547 0.14965024906481 no 2865 0.137917969220078 960 6463691 SGTC_2419 paclitaxel 166.5 µM -1.09184645354065 0.149185522680701 no 2866 0.13745029843228 954 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1959 st077091 55.8 µM -1.09509121459979 0.148477828698832 no 2867 0.136738338596093 936 821356 YKL052C ASK1 SGTC_1558 st069300 45.6 µM -1.09738738805745 0.14797838367752 no 2868 0.136236042132363 938 24208000 SGTC_3142 9086498 49.47 µM -1.09740686392421 0.14797415226019 no 2869 0.136231787121403 916 25236367 SGTC_263 alizarin 107.927 µM -1.09770021637272 0.147910426941183 no 2870 0.136167707630191 972 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1826 st055655 41.6 µM -1.09952449455438 0.147514549121411 no 2871 0.135769677935378 963 676168 SGTC_2801 7907800 81.82 µM -1.10178293855906 0.147025439287792 no 2872 0.135278024744431 935 6620925 SGTC_718 1130-0073 349 µM -1.1029814556731 0.146766319356275 no 2873 0.135017609211524 961 6740020 SGTC_1503 4585-0012 61.3 µM -1.10298560132046 0.146765423597532 no 2874 0.135016709036361 961 2922052 SGTC_1845 st056753 3.01 µM -1.10422047584937 0.146498764924592 no 2875 0.134748754776138 955 5375839 SGTC_1501 4491-0275 38.4 µM -1.10948926494541 0.145364678836095 no 2876 0.133609586472161 947 5104718 SGTC_2643 anethole 100 µM -1.10962702078567 0.145335106873096 no 2877 0.133579891294169 978 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1302 1159-0335 255 µM -1.11082621986195 0.14507784649922 no 2878 0.133321579054876 948 649284 SGTC_2353 9059630 146.67 µM -1.11261038060569 0.144695663695028 no 2879 0.132937900110461 969 4779114 SGTC_1954 st077032 68.9 µM -1.11381781249361 0.144437406331411 no 2880 0.132678676864133 978 698907 SGTC_2775 cyproheptadine 69.59 µM -1.11599214622528 0.14397312228115 no 2881 0.13221274820776 955 2913 A selective serotonin reuptake inhibitor. SGTC_1910 st062352 60.4 µM -1.11641455632955 0.143883042228946 no 2882 0.132122362770592 952 2245730 SGTC_2404 5161160 200 µM -1.1198807527367 0.143145302971837 no 2883 0.131382290652094 943 2831543 SGTC_2706 st078239 82.5 µM -1.12311979732206 0.142458223742718 no 2884 0.13069330955851 962 15434492 SGTC_2301 7769476 200 µM -1.12747541261161 0.141537814978761 no 2885 0.129770765172006 956 977820 SGTC_1312 1218-2183 165 µM -1.12868265253434 0.141283421290871 no 2886 0.129515864917736 956 6744073 SGTC_1447 4239-0816 81.9 µM -1.12985164291706 0.141037383226091 no 2887 0.129269371553914 949 1341554 SGTC_52 0329-0193 875 nM -1.13022495819735 0.14095887260117 no 2888 0.129190722822006 966 3739292 SGTC_1658 st012944 20 µM -1.1308699967365 0.140823286686921 no 2889 0.129054906589851 956 24207260 SGTC_3326 9140064 16.379 µM -1.13329698263938 0.140313931685339 no 2890 0.128544779230197 979 1868434 SGTC_3349 9149703 23.001 µM -1.13864775885015 0.139195381110772 no 2891 0.127425050068415 964 4910494 SGTC_574 1315-0397 40 µM -1.13952404440742 0.139012778272589 no 2892 0.127242322719152 972 6794277 SGTC_364 0083-0097 67.7 µM -1.14304995844224 0.138279687104345 no 2893 0.126508924669734 993 5207356 SGTC_1571 st070080 73.4 µM -1.14306395871708 0.138276781497085 no 2894 0.126506018462653 940 4315245 SGTC_3295 9122362 53.5725 µM -1.14424026572451 0.138032800212514 no 2895 0.126262004227891 1002 4730473 SGTC_3232 9132874 49.47 µM -1.1468304643857 0.137496595060175 no 2896 0.125725847901263 953 3784940 SGTC_2397 5161689 200 µM -1.14857770091422 0.137135698320833 no 2897 0.125365078178143 977 2259942 SGTC_1633 st005664 67.9 µM -1.1516946336201 0.13649349502655 no 2898 0.124723289116045 981 2063822 SGTC_1968 st069590 43.6 µM -1.1519055486099 0.136450113173712 no 2899 0.124679943962323 951 6384066 SGTC_1740 st038286 13.222 µM -1.15641347369926 0.135525159447953 no 2900 0.123756036500449 946 716786 SGTC_466 geldanamycin 89.2 µM -1.15688194683668 0.135429283314675 no 2901 0.123660297736857 950 5288382 HSP90 inhibitor. SGTC_1700 st030840 7.9285 µM -1.15786509213812 0.135228227274698 no 2902 0.123459547471997 965 5499307 SGTC_1128 3448-9350 235 µM -1.15795403959791 0.135210047363072 no 2903 0.123441396392388 955 619386 SGTC_1199 1638-0010 4.46 µM -1.15887535125471 0.135021839656797 no 2904 0.123253498715238 947 3111136 SGTC_3191 9110352 49.47 µM -1.15942117056263 0.134910423201321 no 2905 0.123142275724823 950 17122424 SGTC_2719 novobiocin 32.65 µM -1.16047088254577 0.134696325964932 no 2906 0.122928571016571 983 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1758 st042942 75.2445 µM -1.16785111592209 0.133197650768889 no 2907 0.121433412671116 958 669317 SGTC_1714 st033236 13.627 µM -1.16833367758617 0.133100060100079 no 2908 0.121336097951307 971 2916566 SGTC_923 1900-2434 73.3 µM -1.16971411895307 0.132821158881115 no 2909 0.121058017179754 960 5910570 SGTC_794 k038-0031 316 µM -1.16972194729742 0.132819578408747 no 2910 0.12105644149118 951 6624242 SGTC_2041 5107442 45.335 µM -1.17048104240902 0.132666385438346 no 2911 0.120903719410603 963 793005 SGTC_2604 4'-hydroxychalcone 11.32 µM -1.17181756720384 0.132396957282295 no 2912 0.120635154070996 983 5282362 SGTC_2253 7938677 135.83 µM -1.17293229320069 0.13217252983597 no 2913 0.120411479115009 985 2301972 SGTC_3181 9108277 49.47 µM -1.17456660243723 0.131843969243627 no 2914 0.120084075687268 979 17097298 SGTC_2415 st077333 57.7 µM -1.17585612510621 0.131585122342687 no 2915 0.119826187006153 933 2766255 SGTC_3247 9135149 49.47 µM -1.17608142637467 0.131539933460396 no 2916 0.11978116962494 966 8934436 YOR116C RPO31 SGTC_2182 6325192 200 µM -1.18269715491808 0.130217784358713 no 2917 0.118464596087238 939 736248 SGTC_782 0083-0095 30.5 µM -1.1837892942857 0.130000408395033 no 2918 0.118248240563773 972 3591729 An indicator and reagent. SGTC_1817 st052116 64.4 µM -1.19074612334919 0.128621639430305 no 2919 0.116876632579417 982 4361398 SGTC_1486 3970-0793 4.53 µM -1.1917857825981 0.1284164649202 no 2920 0.116672625949381 986 2844330 SGTC_903 1134-0042 114 µM -1.19219611627597 0.128335549020636 no 2921 0.116592177955643 956 701009 SGTC_2671 danthron 100 µM -1.19307013163941 0.128163315263361 no 2922 0.116420953971213 974 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_186 3455-3465 67.277 µM -1.19307042860947 0.128163256769637 no 2923 0.116420895823621 958 755278 SGTC_981 1488-1094 54.9 µM -1.197773797185 0.127239166404442 no 2924 0.115502545349891 963 3449522 SGTC_1560 lithocholic acid 53.1 µM -1.19944846754392 0.126911258755547 no 2925 0.115176805577384 939 9903 A bile acid which acts as a detergent. SGTC_493 zm226600 134 µM -1.2009412678875 0.126619458320784 no 2926 0.114886992339651 972 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2917 7979103 53.79 µM -1.20130215839532 0.126548984582205 no 2927 0.114817006747518 976 2980565 SGTC_3052 9092717 49.47 µM -1.20318395841207 0.126181954364898 no 2928 0.11445257058454 976 25237534 SGTC_2734 clemastine 41.6 µM -1.20426309764361 0.125971811859943 no 2929 0.114243952482583 1023 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1285 0929-0069 65.5 µM -1.20564016735486 0.125704007438308 no 2930 0.113978132211692 980 1206237 SGTC_377 3970-0964 33.1 µM -1.20908461048356 0.125035892397493 no 2931 0.113315170493577 983 16481235 SGTC_1642 st009582 77.7 µM -1.21101060212368 0.124663392880519 no 2932 0.112945670698573 974 6739311 SGTC_2528 xanthyletin 44.79 µM -1.21201962235441 0.124468551623489 no 2933 0.112752434721056 992 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2057 5236571 38.335 µM -1.21226298495404 0.124421590325313 no 2934 0.11270586406201 964 54684039 YBR257W POP4 SGTC_2061 5245884 80.95 µM -1.21369331743915 0.124145831715381 no 2935 0.112432428575574 985 573863 SGTC_93 0109-0045 59.227 µM -1.2168927776989 0.123530545718402 no 2936 0.111822506941478 988 88733 SGTC_406 estrone 100 µM -1.21810921761192 0.123297174315533 no 2937 0.111591235769995 972 5870 A steroid. SGTC_3277 9138724 49.47 µM -1.22007147105891 0.122921371576681 no 2938 0.111218891188218 988 15943418 SGTC_3303 9125618 40.5795 µM -1.22110012447518 0.122724689267744 no 2939 0.111024056293421 955 22695467 SGTC_1922 5578187 25 µM -1.22215355803217 0.1225234977887 no 2940 0.110824781332868 916 1350412 SGTC_2997 9067075 71.4286 µM -1.22521210397363 0.121940668908075 no 2941 0.110247657577218 958 27209819 SGTC_1053 3366-3204 134 µM -1.22803567373652 0.121404347677557 no 2942 0.109716788310537 995 3632071 YPR165W RHO1 SGTC_2622 2-methoxyxanthone 59.94 µM -1.22912774897195 0.121197359537588 no 2943 0.109511956330763 983 71034 A hepatoprotective. SGTC_1680 diphenhydramine 100 µM -1.22995575137371 0.12104058836914 no 2944 0.109356837561197 960 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2991 9074669 71.4286 µM -1.23010410270795 0.121012515107658 no 2945 0.109329061959539 977 17333109 SGTC_309 k408-0051 1.48 µM -1.23403405719341 0.120270497819931 no 2946 0.108595106889148 955 3640463 SGTC_1393 3470-5649 58.2 µM -1.23501875473423 0.120085079688756 no 2947 0.108411762133104 965 4108395 SGTC_872 0588-0139 234 µM -1.23756134882149 0.119607242233645 no 2948 0.10793937672447 973 2047100 SGTC_2657 nystatin 74.44 µM -1.23920357513577 0.119299327393252 no 2949 0.107635058460526 961 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1174 0739-0097 51.1 µM -1.24311140029461 0.118568867003267 no 2950 0.106913392676358 987 728447 SGTC_1798 st045719 60.953 µM -1.24421724172427 0.118362735316567 no 2951 0.106709809872241 938 3980186 SGTC_3321 9137793 26.8275 µM -1.24865452433857 0.117538162504094 no 2952 0.10589573026406 978 4904192 SGTC_2691 st077356 60.2 µM -1.24963801503835 0.11735595398233 no 2953 0.105715904848012 984 2839272 SGTC_613 3914-0030 117 µM -1.25232620208031 0.116858942116944 no 2954 0.105225512489561 950 1145395 SGTC_1852 st056254 31.4 µM -1.25236102498641 0.116852513604803 no 2955 0.105219170740579 978 442583 SGTC_2987 9018338 71.43 µM -1.25476762010713 0.116408849198509 no 2956 0.104781565133685 978 5055682 SGTC_2735 sertaconazole 140 nM -1.255237467484 0.116322370763722 no 2957 0.104696283962688 1032 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_8 0354-0001 70 µM -1.25821769099251 0.115774902863414 no 2958 0.104156519342207 980 4993152 SGTC_49 0717-0965 32.132 µM -1.25926663991504 0.115582646726793 no 2959 0.103967019254061 1000 5889349 YGL099W LSG1 SGTC_2240 6690706 185.951 µM -1.2629209865917 0.114914633270091 no 2960 0.103308788473123 986 805876 SGTC_1815 st051655 58.2 µM -1.26435369093279 0.114653486167502 no 2961 0.103051553247577 984 5984156 SGTC_333 3486-0131 40.1 µM -1.26446751775761 0.114632756433936 no 2962 0.103031136151521 964 6744690 SGTC_1813 st051246 8.6015 µM -1.26516172267651 0.114506388057751 no 2963 0.102906680348609 974 5291959 SGTC_1422 4031-0024 15.5 µM -1.26774643751752 0.11403675600249 no 2964 0.102444257775101 996 782427 SGTC_1839 st053978 48 µM -1.2691306829485 0.113785809260186 no 2965 0.10219722925898 998 3788398 SGTC_1458 k015-0034 6.33 µM -1.27048923888575 0.113539902644239 no 2966 0.101955206818955 1000 3598957 SGTC_2446 5162541 200 µM -1.27261874231284 0.113155212892726 no 2967 0.101576682278615 1002 1549321 SGTC_738 1315-0003 72.4 µM -1.27349959393445 0.112996361338112 no 2968 0.10142040828196 998 6251474 SGTC_887 0885-0007 9.62 µM -1.27432030193743 0.112848499288439 no 2969 0.101274962178862 1002 5719458 SGTC_2572 astragaloside iv 100 µM -1.27563266287901 0.112612346198934 no 2970 0.101042701109974 976 45006101 An anti-inflammatory agent. SGTC_71 0417-1750 47.813 µM -1.27771421516256 0.112238505038507 no 2971 0.100675105580107 944 6811472 SGTC_785 1270-0111 65.3 µM -1.27845786047956 0.112105163624132 no 2972 0.100544016942407 974 6741994 SGTC_2155 5570423 76 µM -1.28020663174558 0.111792041635362 no 2973 0.100236237097984 995 797402 SGTC_965 1291-5240 308 µM -1.28106966041015 0.111637744872035 no 2974 0.100084599665079 998 2834598 SGTC_617 3770-0098 35 µM -1.28236392946097 0.111406634381792 no 2975 0.0998575056907345 980 5962639 SGTC_1879 gemcitabine 100 µM -1.28422747927602 0.111074472362196 no 2976 0.0995311864792852 1005 60750 A nucleoside analog which inhibits DNA replication. SGTC_1516 st013856 110 µM -1.28752746287261 0.110488019272084 no 2977 0.0989552518838176 999 5281404 A mutagen and neurotoxin. SGTC_1772 st048439 82.2 µM -1.28774056336081 0.110450224789325 no 2978 0.0989181441791061 965 2927068 YDL195W SEC31 SGTC_599 1935-0052 86.5 µM -1.28962163052509 0.110117009688019 no 2979 0.0985910308723414 990 9557311 SGTC_2597 laccaic acid a 100 µM -1.29179384983571 0.10973311739729 no 2980 0.0982142728954684 997 5491415 A textile dye. SGTC_146 3448-8650 53.125 µM -1.29299652014474 0.109520985370323 no 2981 0.0980061313258843 1014 2891488 YIL048W NEO1 SGTC_152 4469-0003 551.229 µM -1.29893430348066 0.108477970130751 no 2982 0.0969832380276779 985 697280 SGTC_3185 9108267 49.47 µM -1.29939485981654 0.108397369691522 no 2983 0.0969042274014754 990 4910486 SGTC_418 lividomycin a 100 µM -1.30198171451474 0.107945453512382 no 2984 0.0964613182541496 987 72394 An antibiotic. SGTC_901 1112-0062 60.1 µM -1.30318548516253 0.107735621397192 no 2985 0.09625572214533 977 1908457 SGTC_1994 st072947 40.9 µM -1.30641240558896 0.107174579238269 no 2986 0.0957061746736845 999 5286565 YDL195W SEC31 SGTC_2655 perillic acid 100 µM -1.3091631286597 0.106697996126855 no 2987 0.095239549476539 1005 5702197 An apoptosis inducer. SGTC_334 1502-1024 68.5 µM -1.31052890069043 0.106461935071649 no 2988 0.0950084869458872 1002 3296216 SGTC_958 1222-0007 33 µM -1.31162280415514 0.106273136118555 no 2989 0.0948237174101597 987 7312461 SGTC_219 mitoxanthrone 164.414 µM -1.31162667559334 0.106272468369114 no 2990 0.094823063962078 1013 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1349 flufenamic acid 69 µM -1.31290897491138 0.106051462826914 no 2991 0.0946068111431338 995 3371 A non-steroidal anti-inflammatory. SGTC_593 1203-0218 61.7 µM -1.31546240916643 0.105612365347096 no 2992 0.0941772714533191 1006 3666956 SGTC_2571 chrysanthemic acid 100 µM -1.31871167939949 0.105055512255424 no 2993 0.0936327603383506 1017 2743 An insecticide. SGTC_576 1073-0113 22.7 µM -1.31883141606664 0.105035032713278 no 2994 0.0936127394296861 1009 5439563 SGTC_1790 st045711 43.5 µM -1.31964839021416 0.104895376057494 no 2995 0.0934762193131652 949 585119 SGTC_1727 st034309 9.9045 µM -1.31999788627593 0.104835672952269 no 2996 0.0934178618528081 1011 870305 SGTC_1160 4092-0570 10.5 µM -1.32342588217356 0.104251385075834 no 2997 0.0928468946538748 1006 4994975 SGTC_2594 a-mangostin 100 µM -1.32820500322182 0.103440747859253 no 2998 0.0920551960083235 1010 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2488 5268135 45.7 µM -1.32959908661789 0.103205146885747 no 2999 0.0918251996165456 992 1270356 YLR208W SEC13 SGTC_1409 3909-8004 61.9 µM -1.33050948712913 0.103051499094292 no 3000 0.0916752313200195 1002 2119279 SGTC_3161 9100388 49.47 µM -1.33192862271574 0.102812323829159 no 3001 0.0914418222291337 1017 25236368 SGTC_2161 5662504 8.5105 µM -1.33274855998841 0.102674318966813 no 3002 0.0913071658399957 949 2859334 SGTC_3041 9091929 49.47 µM -1.33304639046929 0.102624224025449 no 3003 0.0912582902495747 987 25236887 SGTC_1856 st057054 55.7 µM -1.33712056708424 0.101940732536747 no 3004 0.0905916423579738 998 1266018 SGTC_155 k072-0202 43.6 µM -1.3415934042023 0.101194182698158 no 3005 0.0898639329894935 995 5857737 SGTC_1175 0741-0056 27.6 µM -1.34320908653283 0.100925495146238 no 3006 0.0896021401127418 1006 765927 SGTC_666 0272-0154 136 µM -1.34464248604257 0.100687556911402 no 3007 0.0893703580703084 1018 6870312 SGTC_839 0122-0028 230 µM -1.34745594259215 0.100221725198993 no 3008 0.088916716866286 981 759448 SGTC_736 0958-0254 92.6 µM -1.34975635533959 0.099842010132347 no 3009 0.0885470744055799 1005 6812352 SGTC_1473 k844-0725 134 µM -1.355240933967 0.0989409457973834 no 3010 0.0876704034215032 994 54682906 SGTC_2772 vinpocetine 57.06 µM -1.3555945944167 0.0988830475806401 no 3011 0.0876140963526254 1003 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2286 7945697 125 µM -1.35628820088671 0.0987695683452486 no 3012 0.0875037440829731 998 1245733 SGTC_2789 5281112 71.43 µM -1.36200138374472 0.0978384723595587 no 3013 0.0865987242110122 987 765948 SGTC_2217 6934799 96.0675 µM -1.36349533224653 0.0975960632885023 no 3014 0.0863632272761353 1006 675606 SGTC_2148 5546263 113.568 µM -1.36421945961604 0.0974787245044464 no 3015 0.0862492527134663 1026 792097 SGTC_1294 1000-1494 117 µM -1.36464918552244 0.0974091399558621 no 3016 0.0861816688977705 1007 712797 YDL207W GLE1 SGTC_1286 0929-0070 131 µM -1.36869947341478 0.0967550754059001 no 3017 0.0855466174976721 996 1420408 SGTC_2031 5180455 200 µM -1.3693408180046 0.0966518037557324 no 3018 0.0854463822102852 1014 29949 SGTC_1100 amiodarone 5.07 µM -1.3710225739216 0.0963813858238888 no 3019 0.0851839595672295 996 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_3136 9095672 49.47 µM -1.37203518795335 0.0962188309583623 no 3020 0.0850262419525063 971 17217380 SGTC_2014 4013930 200 µM -1.37597211073334 0.0955887517851131 no 3021 0.0844151339525927 1007 64556 SGTC_1911 st060208 74.3 µM -1.3801859678164 0.0949177208590636 no 3022 0.0837646966618024 1011 688783 SGTC_1604 st002052 72.4 µM -1.38049535862095 0.0948685893748777 no 3023 0.0837170888665053 998 6254834 YHR062C RPP1 SGTC_2762 leflunomide 42.06 µM -1.38114072096475 0.0947661656792296 no 3024 0.0836178485661465 1023 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1233 0325-0408 14.2 µM -1.38218142258192 0.0946011704646942 no 3025 0.0834580013842371 1002 12874 SGTC_1389 3405-0187 19 µM -1.38272165320945 0.0945156046046463 no 3026 0.0833751149435092 994 799890 SGTC_2755 lomerizine 42.69 µM -1.38332888064565 0.0944194954048368 no 3027 0.0832820232046609 986 3949 A calcium channel blocker. SGTC_2674 ligustilide 100 µM -1.38408800764368 0.0942994456161334 no 3028 0.083165754254212 1011 5319022 A signalling regulator. SGTC_2044 5102272 200 µM -1.38878086983259 0.0935598056430583 no 3029 0.0824496970652056 1004 592666 SGTC_2877 9040724 71.43 µM -1.38912256904581 0.093506118380783 no 3030 0.0823977409778214 1013 6463895 SGTC_562 3772-2733 112 µM -1.38919688674413 0.0934944447097606 no 3031 0.0823864440793518 998 2876874 YIL048W NEO1 SGTC_440 fluspirilene 35.1 µM -1.39081126443809 0.0932411271713703 no 3032 0.0821413331856449 1018 3396 An atypical antipsychotic. SGTC_1953 st076800 12.1 µM -1.39307138661633 0.0928873361486985 no 3033 0.0817991023417705 987 297591 SGTC_1229 0139-0193 12.2 µM -1.39312375437066 0.0928791504785785 no 3034 0.0817911855022717 988 3090752 SGTC_1930 st074634 34.3 µM -1.39585228501831 0.0924533879003103 no 3035 0.081379490882546 999 684253 YOR116C RPO31 SGTC_2619 obliquin 87.91 µM -1.3963381712326 0.0923777214603624 no 3036 0.0813063421352155 985 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1764 st044502 93.5 µM -1.39825748697228 0.0920792768913083 no 3037 0.0810178796575813 1000 8407 SGTC_1905 st060207 84.5 µM -1.39862388489042 0.0920223849765305 no 3038 0.0809629000004233 1000 1948547 SGTC_877 0771-0151 33.1 µM -1.39917863993988 0.0919362957209546 no 3039 0.0808797101149125 1018 6166523 SGTC_2860 9025725 38.96 µM -1.40153447216648 0.0915713720242551 no 3040 0.0805271533028989 1028 40546248 SGTC_132 0417-1715 25.805 µM -1.40159941899444 0.0915613268408309 no 3041 0.080517450299956 1013 6769098 SGTC_330 1488-0319 80.1 µM -1.40272541069054 0.0913873019572283 no 3042 0.080349368421403 989 6846614 SGTC_2704 st078022 71.1 µM -1.40345775204888 0.091274248402249 no 3043 0.0802401908952823 1006 54697681 SGTC_1029 k015-0030 64.7 µM -1.40748063732375 0.0906550732690057 no 3044 0.0796424574265629 998 2208316 SGTC_561 1550-0330 72.9 µM -1.4093351277769 0.0903706948036919 no 3045 0.079368048212315 1015 6812934 SGTC_3344 9148862 3.898 µM -1.4099317561135 0.0902793452997895 no 3046 0.0792799173634625 1027 4905352 SGTC_1267 0828-0272 9.49 µM -1.4111332469136 0.0900955937154439 no 3047 0.0791026642101348 1010 745334 SGTC_931 2812-0076 566 µM -1.41602366483371 0.0893505379305339 no 3048 0.0783842879441545 1017 3450959 SGTC_803 4488-1585 147 µM -1.42013521936765 0.0887276967753969 no 3049 0.0777841593265583 991 747204 SGTC_1000 4048-0884 8.67 µM -1.42016133479697 0.088723751025146 no 3050 0.0777803586571802 1012 13040088 SGTC_188 3229-0966 278.469 µM -1.42127103651701 0.0885562081912196 no 3051 0.0776189901173275 992 5722370 SGTC_453 enantio-paf c16 10 µM -1.42310483898998 0.0882798573024034 no 3052 0.0773528829029608 1001 13871343 A lipid and platelet activating factor SGTC_2110 5483698 200 µM -1.42328902898656 0.0882521357459678 no 3053 0.0773261930213753 999 2848765 YHR062C RPP1 SGTC_2781 5567276 71.43 µM -1.42478813971731 0.0880267530099939 no 3054 0.0771092258662303 997 2853274 SGTC_515 4092-1064 102 µM -1.42560361038077 0.087904332021239 no 3055 0.0769913967624133 1029 717353 SGTC_1063 disulfiram 1.84 µM -1.42602568755274 0.0878410183740897 no 3056 0.0769304636992093 1017 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1355 1499-0035 1.68 µM -1.42657485948487 0.0877586908151028 no 3057 0.0768512375183643 1021 1548538 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.42960158673005 0.0873059801268774 no 3058 0.076415699942486 1016 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1423 4048-0112 5.59 µM -1.43200706238794 0.0869474358667517 no 3059 0.0760709000753617 1006 X1423 SGTC_2621 lithochol-11-enic acid 100 µM -1.43282291041406 0.0868260811017081 no 3060 0.0759542261309612 1021 6708711 SGTC_3242 9133940 49.47 µM -1.43484162903419 0.0865263472726673 no 3061 0.0756661161170693 1014 17248444 SGTC_3102 9121669 49.47 µM -1.43561357522604 0.0864119354881148 no 3062 0.0755561648538393 1038 41905072 SGTC_1665 st014639 11.4 µM -1.43672924765927 0.0862467792446464 no 3063 0.0753974705170909 1009 981133 YIL048W NEO1 SGTC_811 0416-0114 265 µM -1.43828937425625 0.0860162252146801 no 3064 0.075175982760213 1002 6612453 SGTC_2798 7813637 45.45 µM -1.44556540404456 0.084947068018081 no 3065 0.0741495680109093 1008 956368 SGTC_3355 9151058 44.0485 µM -1.44791653414095 0.0846037257474644 no 3066 0.0738201974682907 1030 17015728 SGTC_356 1634-0012 32.5 µM -1.4496451344369 0.0843519580188255 no 3067 0.0735787514471302 1013 735457 SGTC_1348 1493-0373 93.8 µM -1.45241190355976 0.0839501534644802 no 3068 0.073193554222567 1026 3010129 SGTC_2662 daunorubicin 22.37 µM -1.45987941527086 0.0828728587183151 no 3069 0.0721616087607428 985 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2556 citropten 84.59 µM -1.46116258432586 0.0826887951605646 no 3070 0.0719854141952069 1004 2775 A potential DNA crosslinker. SGTC_3276 9139060 49.47 µM -1.46293860466185 0.0824345426246142 no 3071 0.0717420896766256 1032 4870619 SGTC_2702 st077768 96.8 µM -1.46585534102116 0.0820182645679557 no 3072 0.0713438503250235 994 6484119 SGTC_682 0kpi-0099 17 µM -1.46608990068258 0.0819848570281908 no 3073 0.071311898363192 1014 1714895 YML126C ERG13 SGTC_2432 5630864 12.22 µM -1.46761409139291 0.0817680214373668 no 3074 0.0711045390594237 1014 5714970 SGTC_1511 0906-3109 28.5 µM -1.47331642338268 0.0809606249110967 no 3075 0.0703328671313435 1013 2882180 SGTC_2568 diosmetin 100 µM -1.47371512049161 0.0809043990451935 no 3076 0.0702791549878064 1014 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_940 3232-1287 54.8 µM -1.47445500736531 0.0808001353472602 no 3077 0.0701795616366562 1017 1585493 YIL048W NEO1 SGTC_2387 9077560 195.08 µM -1.47889967484411 0.0801759340354085 no 3078 0.0695835651388273 1011 5303272 SGTC_1857 st056007 79.3 µM -1.48126822261266 0.07984479152125 no 3079 0.0692675564252237 1015 619834 SGTC_131 0141-0277 33.849 µM -1.4856851653033 0.0792300310950757 no 3080 0.0686812081561513 1035 1547771 SGTC_1058 3448-5425 97.3 µM -1.48998225800632 0.0786353972980567 no 3081 0.0681144505096076 1019 7279705 SGTC_850 0388-0143 75.9 µM -1.49185082207994 0.0783778821498966 no 3082 0.0678691286355861 1026 67273 SGTC_2180 6301957 200 µM -1.4926685321274 0.0782653912252447 no 3083 0.0677619871948519 1010 845462 SGTC_2414 st077232 92.9 µM -1.49825758361174 0.0774997914472299 no 3084 0.0670331699058076 1011 729801 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.50011996420032 0.0772459460504368 no 3085 0.0667916651919756 1026 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2728 chlorpromazine 9.18 µM -1.50251716883648 0.0769201337396984 no 3086 0.0664817986637881 1061 2726 A thorazine and dopamine antagonist. SGTC_2897 9048598 12.99 µM -1.50320664555435 0.0768266182977061 no 3087 0.0663928821870351 1031 6467404 SGTC_1940 st075990 51.1 µM -1.50341595689067 0.0767982459908059 no 3088 0.0663659071515696 1029 1084979 SGTC_2059 5238311 157 µM -1.50354728745481 0.0767804481032915 no 3089 0.066348986235249 1012 703021 SGTC_354 2783-3500 4.88 µM -1.51114831367081 0.0757556933751112 no 3090 0.0653753338180387 1009 6740761 SGTC_3148 9097893 49.47 µM -1.51122762253967 0.0757450563038398 no 3091 0.0653652335002111 986 17174100 SGTC_1660 st012960 28.1 µM -1.51579768520239 0.0751340296176735 no 3092 0.0647852587845812 1014 24207266 SGTC_2333 9017922 200 µM -1.51750599525135 0.0749065926562343 no 3093 0.0645694904929362 1013 3163164 SGTC_2314 7727897 200 µM -1.52327292000857 0.0741426874856251 no 3094 0.0638452196033789 992 900724 SGTC_1316 1272-0050 65.9 µM -1.5252797311362 0.0738782591931146 no 3095 0.0635946705387633 1032 7340392 SGTC_2064 5220758 200 µM -1.52945066442329 0.0733309807546045 no 3096 0.0630763803430207 1014 788518 SGTC_257 daunorubicin 18.5 µM -1.5353321659124 0.0725645311549064 no 3097 0.0623511284385289 1003 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_552 k242-0005 476 µM -1.54070960600753 0.0718691519813693 no 3098 0.0616937389245239 1038 4088318 SGTC_1561 5-methoxyflavone 52.9 µM -1.5434955960003 0.0715108994375674 no 3099 0.0613552876086721 1008 94525 SGTC_1135 dihydrocapsaicin 536.708 nM -1.54564200568364 0.0712358268249414 no 3100 0.0610955252642577 1027 107982 A Capsaicinoid. SGTC_792 4534-1957 155 µM -1.54932844092609 0.0707652892669737 no 3101 0.060651393089287 1027 1717904 SGTC_1909 st060837 51.5 µM -1.55096588776077 0.0705570526575982 no 3102 0.0604549295216719 1001 678937 SGTC_1151 3909-8316 15.3 µM -1.56123671003841 0.0692616233747837 no 3103 0.0592339551868563 1037 800431 SGTC_15 0266-0086 27.098 µM -1.5641934414256 0.0688921167109996 no 3104 0.058886073492157 1053 1712902 YIL048W NEO1 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.56524487037671 0.0687610851427198 no 3105 0.0587627520942115 1055 442882 SGTC_2396 5342950 42.78 µM -1.56698316178119 0.0685448767304681 no 3106 0.0585593137357159 993 1886677 SGTC_2472 5377652 49.4 µM -1.57022786423935 0.0681427045976542 no 3107 0.0581810546350526 1046 1610903 SGTC_316 k060-0003 58.6 µM -1.57193943015675 0.0679312956936729 no 3108 0.0579822994772513 1044 6152314 SGTC_1883 5-benzylidenerhodanine 20 µM -1.57209153395536 0.0679125326945812 no 3109 0.0579646623125979 1008 1273210 SGTC_3129 9127257 49.47 µM -1.57380091705036 0.0677019442194573 no 3110 0.0577667409974715 1029 837894 SGTC_2912 7964298 10.93 µM -1.57457385721558 0.0676068871710305 no 3111 0.0576774205730774 1005 2975850 SGTC_859 0439-0102 54.6 µM -1.57683362327753 0.0673295700127315 no 3112 0.0574169064126694 1021 610143 SGTC_1017 4239-0030 168 µM -1.5800860666474 0.0669319766963027 no 3113 0.0570435788635376 1025 1149593 SGTC_3019 9081971 49.47 µM -1.5824262770545 0.0666470241497067 no 3114 0.0567761449748936 1035 16451803 SGTC_1344 1488-0097 29.1 µM -1.58259969603097 0.0666259454465364 no 3115 0.0567563664195303 1040 747966 SGTC_5 0352-0601 109.883 µM -1.58478549755867 0.0663607081476598 no 3116 0.0565075392596031 1014 762456 SGTC_428 3448-4153 16.5 µM -1.58637083249356 0.0661688468995379 no 3117 0.0563276064419391 1022 3834874 SGTC_124 0136-0217 7.121 µM -1.59102029134362 0.0656086351648143 no 3118 0.0558025046355585 1020 3976905 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.59226132400447 0.0654597271103412 no 3119 0.0556629996362586 1023 2724 A muscle relaxant with antifungal properties. SGTC_3182 9108849 49.47 µM -1.59230344920652 0.0654546772279958 no 3120 0.0556582691592124 1025 17133045 SGTC_91 0417-1751 58.384 µM -1.59650265034912 0.0649528002286055 no 3121 0.0551883072537139 1042 6795624 SGTC_605 1315-0399 119 µM -1.59756998819779 0.0648257122838232 no 3122 0.0550693550368856 1040 24020461 SGTC_1077 5-fluorocytosine 377 nM -1.59785850682357 0.0647913915339422 no 3123 0.055037235139047 1033 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_321 4534-3890 65.3 µM -1.59789124801812 0.0647874976948021 no 3124 0.0550335910972031 1026 699746 SGTC_1711 st032263 62.8 µM -1.60015709633986 0.0645184664298335 no 3125 0.0547818686322594 1035 3958979 SGTC_959 1222-0044 107 µM -1.60027510932276 0.0645044781925684 no 3126 0.0547687830592962 1017 6083612 SGTC_1134 3477-0009 42.5 µM -1.60398236901131 0.0640662501704613 no 3127 0.0543589694807314 1021 3973534 SGTC_723 4182-0001 115 µM -1.60734046581071 0.0636712972014696 no 3128 0.0539898510369626 1024 744821 YLR208W SEC13 SGTC_3249 9135183 49.47 µM -1.60752423456476 0.0636497385549854 no 3129 0.0539697087731548 990 4902779 SGTC_3343 9148379 18.9835 µM -1.61607091407942 0.0626533539137945 no 3130 0.0530394909795414 985 1955036 SGTC_97 0535-0701 19.132 µM -1.61736365719972 0.0625037082849394 no 3131 0.0528999028886583 997 2832013 YGL099W LSG1 SGTC_3137 9097352 49.47 µM -1.62707602392435 0.0613883172201798 no 3132 0.0518604762339287 1013 44120435 SGTC_1653 st012112 65 µM -1.6283230234535 0.0612462423061107 no 3133 0.0517282050456074 1036 720429 SGTC_1721 st082152 9.2685 µM -1.62925417694661 0.0611403204630299 no 3134 0.0516296111344044 1022 5296051 SGTC_3063 1327-0034 4 µM -1.63130539551104 0.0609074925293888 no 3135 0.0514129477372726 1020 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2889 9059656 51.95 µM -1.63288255212346 0.0607289458698964 no 3136 0.051246850204619 1049 3949838 SGTC_3014 9081533 49.47 µM -1.63608383087564 0.0603677946014159 no 3137 0.0509110218608004 1042 21367265 SGTC_1325 1431-0015 227 µM -1.64222567748162 0.0596796120487295 no 3138 0.0502716215708551 1040 1103340 SGTC_1500 4488-1866 171 µM -1.6453149322999 0.0593357981081069 no 3139 0.0499524410248446 1046 2900003 SGTC_2433 5607874 27.82 µM -1.64863479457745 0.0589680522723026 no 3140 0.0496112379828274 1018 2252428 SGTC_308 4092-1169 104 µM -1.64866497145904 0.058964717756086 no 3141 0.0496081450667214 1040 2268590 YDL196W YDL196W SGTC_2486 5283202 22.39 µM -1.65530778671657 0.0582342867931472 no 3142 0.0489310401155993 1023 1377751 SGTC_1446 4239-0190 62 µM -1.6558394821987 0.0581761312109203 no 3143 0.0488771649091089 1052 1340085 SGTC_1819 st053448 58.6 µM -1.65726239471058 0.0580207208806923 no 3144 0.0487332183342479 1058 2857616 SGTC_2364 9055074 200 µM -1.66625746305535 0.0570458186760178 no 3145 0.0478310725602781 1034 6470630 SGTC_1143 3454-2408 5.08 µM -1.6667219143165 0.056995832865132 no 3146 0.0477848566477084 990 X1143 SGTC_1915 st067105 30.6 µM -1.66777612615526 0.0568825030038035 no 3147 0.0476800884157337 1026 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1902 st060212 70.5 µM -1.67168886361025 0.0564634269077451 no 3148 0.0472928456377994 1023 688944 SGTC_2844 9010103 25.97 µM -1.67197585579315 0.0564327844733907 no 3149 0.0472645415926778 1029 2480525 SGTC_936 3005-4620 401 µM -1.67481661852083 0.0561301799475868 no 3150 0.0469851086206334 1033 777207 SGTC_883 0850-0245 24.6 µM -1.6772894812573 0.0558678079783885 no 3151 0.0467429442348008 1028 6823229 YPR165W RHO1 SGTC_3085 9117376 49.47 µM -1.6782241730201 0.0557688890602022 no 3152 0.0466516722076432 1035 16480349 SGTC_109 0132-0036 33.701 µM -1.68879182491228 0.0546600987810861 no 3153 0.0456296655183225 1000 67274 A color developer. SGTC_1750 st081859 2.357 µM -1.68931655628839 0.0546054998958046 no 3154 0.0455793911221172 1021 5291695 SGTC_3284 9108171 64.8615 µM -1.68991775089913 0.0545429979447917 no 3155 0.0455218455538512 1020 8687505 SGTC_1193 1488-0126 41.5 µM -1.69041852133965 0.0544909795857981 no 3156 0.045473957067094 1036 1384710 SGTC_885 0865-0106 16.8 µM -1.69616736434502 0.0538966157948631 no 3157 0.0449270945450488 1045 2793380 SGTC_1374 2889-5571 141 µM -1.69673569992613 0.0538381363715763 no 3158 0.0448733200304979 1034 2853281 SGTC_1553 gossypol 38.6 µM -1.70718132058282 0.0527722469759777 no 3159 0.0438941779131455 1031 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1225 1216-0074 20.6 µM -1.70862518935302 0.0526262383048217 no 3160 0.0437601998196641 1048 4241466 SGTC_3109 9122853 49.47 µM -1.71265426204934 0.0522205005243435 no 3161 0.0433880821344133 1066 1234709 SGTC_2141 5621638 7.665 µM -1.71444981906822 0.0520404855099511 no 3162 0.0432230728075482 1047 2856238 SGTC_3194 9111903 49.47 µM -1.71976336658098 0.0515106584348591 no 3163 0.0427377320650664 1054 17087251 SGTC_2444 5485484 36.41 µM -1.71997815194722 0.0514893321864929 no 3164 0.0427182065321536 1057 6790631 SGTC_389 tpck 16.7 µM -1.72836418240546 0.0506621501408551 no 3165 0.0419614763947521 1061 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1643 st009866 20.2 µM -1.72839217352698 0.0506594069786629 no 3166 0.0419589688520383 1022 3156273 YOR207C RET1 SGTC_1032 k061-1018 98.7 µM -1.72934417013955 0.0505661806238292 no 3167 0.0418737578599465 1050 4005393 SGTC_964 1287-0107 19.4 µM -1.73237745040161 0.0502700511649232 no 3168 0.0416031900995819 1036 51516812 YPR165W RHO1 SGTC_99 0109-0120 622.8 µM -1.73577326725798 0.0499401700666017 no 3169 0.0413019663409189 1044 759414 SGTC_251 melphalan 456.522 µM -1.73719260915929 0.049802803008333 no 3170 0.0411765895247582 1063 460612 A DNA alkylator. SGTC_3224 9130643 49.47 µM -1.73813146356049 0.0497121043433098 no 3171 0.0410938260138658 1029 17644395 SGTC_1282 0886-0010 32.4 µM -1.7419529126523 0.0493442897766734 no 3172 0.0407583420137805 1030 2836211 YNL267W PIK1 SGTC_1268 0828-0275 2.46 µM -1.74252375320422 0.0492895333594777 no 3173 0.0407084193932571 1058 745337 SGTC_1688 st021091 57.6 µM -1.74337825669354 0.0492076579840396 no 3174 0.0406337818969805 1068 3656366 SGTC_2440 5628896 157.78 µM -1.74727023445877 0.0488361160216528 no 3175 0.0402952368615987 1049 5522048 SGTC_767 0929-0023 86 µM -1.75468417572712 0.0481345600037097 no 3176 0.0396566721154365 1049 1204563 SGTC_1632 st005650 90 µM -1.76520178434233 0.0471531750126747 no 3177 0.0387649294226198 1041 2759605 SGTC_523 1934-0222 13.7 µM -1.76727961061887 0.0469612061769576 no 3178 0.0385907063831737 1056 1361595 SGTC_129 0088-0017 176.636 µM -1.76775385213833 0.0469174793194745 no 3179 0.0385510314129666 1050 182446 SGTC_3143 9086658 49.47 µM -1.7685068734162 0.0468481150105503 no 3180 0.0384881020728175 1024 25236626 SGTC_2777 climbazole 1.536 µM -1.77380495868543 0.0463624060019279 no 3181 0.0380477088169916 1059 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2470 5664817 21.68 µM -1.77499412876546 0.0462539447196641 no 3182 0.0379494283151318 1067 2859561 SGTC_1955 wogonin 32.4 µM -1.78567746168588 0.0452886562552222 no 3183 0.0370757483399289 1033 5281703 A flavanone. SGTC_821 1114-0266 29.2 µM -1.80257973419469 0.0437946240381477 no 3184 0.035727121057915 1052 3123235 SGTC_1046 2001-0062 216 µM -1.80418944786417 0.0436544358539208 no 3185 0.0356008064964372 1051 739778 SGTC_2261 9010538 184.68 µM -1.80567355542286 0.0435255076122023 no 3186 0.0354846728431696 1052 6457250 SGTC_2332 7982454 138.89 µM -1.80923721010629 0.0432171785758263 no 3187 0.0352070795468304 1055 2981748 SGTC_2534 helenine 20.12 µM -1.81003819651651 0.0431481202304643 no 3188 0.0351449320090443 1036 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_161 4065-0411 162.148 µM -1.81090212643463 0.0430737350511446 no 3189 0.0350780016884519 1052 1906281 YLR208W SEC13 SGTC_558 k064-0027 21.3 µM -1.81409119756884 0.0428000495710412 no 3190 0.0348318432633485 1053 5088526 SGTC_2348 9022543 33.42 µM -1.81592260030516 0.0426435153660865 no 3191 0.0346911229621819 1029 3162678 YDL140C RPO21 SGTC_685 1278-0033 54.9 µM -1.81670971375288 0.042576381337983 no 3192 0.0346307867941675 1055 3590572 SGTC_31 0508-1974 57.237 µM -1.81871740548913 0.0424055293962204 no 3193 0.0344772774387409 1042 6810525 SGTC_2513 baicalein 25.65 µM -1.82436545935008 0.0419278602783666 no 3194 0.0340484201221418 1067 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2813 7971799 71.43 µM -1.82915043835102 0.0415266003705746 no 3195 0.0336885373628233 1049 2234054 SGTC_3175 9106517 49.47 µM -1.83020478107745 0.0414386047004857 no 3196 0.033609661572447 1063 41468073 SGTC_2558 carylophyllene oxide 100 µM -1.83426792486935 0.0411009060795377 no 3197 0.0333071164753874 1063 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2088 5278280 127.392 µM -1.83495518521439 0.0410440073253791 no 3198 0.0332561649389941 1064 791502 SGTC_3103 9120822 49.47 µM -1.83848074443108 0.0407531274665004 no 3199 0.0329957983487083 1036 17141819 SGTC_2099 5377090 177.372 µM -1.84511305523631 0.0402104561422161 no 3200 0.0325105472426781 1046 2243829 SGTC_1030 k029-0042 36.7 µM -1.85016381427202 0.0398011404487361 no 3201 0.0321449713293869 1044 6080581 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.86345897682525 0.0387398691461983 no 3202 0.0311988595280785 1066 6708561 SGTC_2280 7785178 200 µM -1.86467822360529 0.0386437091276291 no 3203 0.0311132604681811 1043 2954328 SGTC_3152 9099253 49.47 µM -1.87561153637351 0.0377900799058316 no 3204 0.0303543205656877 1016 25236131 SGTC_3273 9137859 49.47 µM -1.8768812870542 0.0376919480638584 no 3205 0.0302671830785557 1077 2377234 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.87722901383997 0.0376651105426887 no 3206 0.0302433562896097 1063 16623 A steroid. SGTC_397 arbidol 50 µM -1.87818119561632 0.0375917010775166 no 3207 0.0301781908481036 1061 131410 A RNA synthesis inhibitor. SGTC_361 000s-0510 1.45 µM -1.88033709643158 0.0374259212495252 no 3208 0.0300310752859503 1038 660 SGTC_1360 1598-0022 39.8 µM -1.88691211702638 0.0369240136557968 no 3209 0.0295860735352449 1069 761525 SGTC_963 1269-2853 151 µM -1.89144200049954 0.0365814346839406 no 3210 0.0292826832100768 1056 3668223 SGTC_525 k781-2675 26.7 µM -1.89769338688906 0.0361129393630994 no 3211 0.028868242116275 1033 3651118 YDL195W SEC31 SGTC_2816 7982706 58.44 µM -1.90045019856371 0.03590790352565 no 3212 0.0286870323018136 1046 2981853 SGTC_2213 7173844 200 µM -1.9124837483976 0.0350240548716193 no 3213 0.0279070875785506 1066 892728 SGTC_991 3996-0057 64.7 µM -1.92176314506676 0.0343547549450995 no 3214 0.0273177838493828 1057 715343 SGTC_2232 chlorophetanol 41.5365 µM -1.92351456382828 0.0342296161647816 no 3215 0.0272077296255293 1076 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1227 3909-8010 46.6 µM -1.92659344340014 0.0340105387778466 no 3216 0.0270151582029036 1056 15982272 SGTC_1554 st069299 38.7 µM -1.92789892893325 0.033917995835411 no 3217 0.026933849501832 1053 24207999 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.93608319889529 0.0333425399005068 no 3218 0.0264287559560244 1045 6857784 SGTC_2593 nobiletin 86.24 µM -1.93853806788314 0.0331715079051463 no 3219 0.0262788055539834 1052 72344 An anti-infammatory. SGTC_519 k048-0011 62.8 µM -1.94839245558306 0.0324922058696944 no 3220 0.0256840109287888 1048 6836379 SGTC_3 0833-0587 95.581 µM -1.95186850920002 0.0322553426566968 no 3221 0.0254769089465057 1051 5382644 SGTC_1733 st037357 54.9 µM -1.95595991142856 0.0319783764448435 no 3222 0.0252349383794664 1051 1272339 YGL099W LSG1 SGTC_2557 derrustone 83.84 µM -1.9605268767713 0.0316715398093346 no 3223 0.0249671198668028 1056 629853 An antioxidant. SGTC_1779 st039427 55 µM -1.97831675947109 0.0304994148923495 no 3224 0.0239464918052397 1062 1124498 SGTC_2607 solasodine 47.35 µM -1.97911923169902 0.0304474008066409 no 3225 0.0239012918390216 1057 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_3087 9117406 49.47 µM -1.9819121482929 0.030266944152083 no 3226 0.0237445370203106 1059 42546093 SGTC_180 1486-1293 102.781 µM -1.9885866359235 0.0298392785577599 no 3227 0.0233734238443127 1050 4140536 SGTC_1033 k072-0102 21.3 µM -1.99558093453862 0.0293965122148961 no 3228 0.0229897782379702 1047 5965931 SGTC_2512 diallyl trisulfide 49.23 µM -2.00025919188533 0.0291034156575577 no 3229 0.0227361415544443 1076 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_3279 9140807 49.47 µM -2.00195293107107 0.0289979019642153 no 3230 0.0226448970294063 1071 45595718 SGTC_1939 st074455 53.6 µM -2.00696423812822 0.0286875762785602 no 3231 0.022376735487926 1067 1644229 SGTC_44 0929-0055 61.211 µM -2.01144650128672 0.0284123561957588 no 3232 0.0221391578973337 1035 1379590 SGTC_680 0417-1641 114 µM -2.01997055742367 0.0278950228321943 no 3233 0.0216932208103711 1068 2835990 SGTC_332 4112-0506 40.9 µM -2.02291244632555 0.0277183080689472 no 3234 0.0215410875507739 1066 2790355 SGTC_2210 7115885 190.385 µM -2.03645114970774 0.0269170414836582 no 3235 0.0208525368387694 1084 2927039 SGTC_514 4466-0038 2.65 nM -2.04282129662251 0.0265467772247563 no 3236 0.020535065780137 1027 5722064 SGTC_3324 9138759 60.749 µM -2.04288960139982 0.0265428301910671 no 3237 0.0205316839670405 1062 45595710 SGTC_227 fluconazole 33.516 µM -2.04549362385778 0.0263927203993219 no 3238 0.0204031085907812 1063 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_808 0711-0032 135 µM -2.05645242813767 0.0257687504575578 no 3239 0.0198694636082503 1073 4252555 SGTC_1172 0370-0043 85 µM -2.0569760045069 0.0257392508569242 no 3240 0.0198442670420952 1075 376585 SGTC_878 0828-0289 13.7 µM -2.05716673516892 0.0257285116410937 no 3241 0.0198350950688522 1059 745350 YLR208W SEC13 SGTC_1489 4065-0444 182 µM -2.06316219221611 0.0253928404568887 no 3242 0.0195486104581978 1066 2877968 SGTC_23 0213-0011 39.996 µM -2.07778632159572 0.0245894300667369 no 3243 0.0188645221108045 1065 627608 SGTC_3075 9116269 49.47 µM -2.08351359243585 0.0242806554962346 no 3244 0.0186022170192049 1059 17015205 YNL244C SUI1 SGTC_2307 7538926 6.34 µM -2.08391595813966 0.0242590856957374 no 3245 0.0185839062522866 1055 96582 SGTC_3031 9088762 49.47 µM -2.08403950288443 0.0242524660065381 no 3246 0.0185782870861726 1072 205253 SGTC_1445 4239-0156 97.7 µM -2.08449702373976 0.0242279646496349 no 3247 0.0185574903331814 1080 4008346 SGTC_993 3909-8757 62.7 µM -2.08784410420776 0.0240493519374539 no 3248 0.0184059498260104 1062 4288324 YLR208W SEC13 SGTC_2876 9059903 25.97 µM -2.0897410832808 0.023948614158295 no 3249 0.0183205321840773 1067 6916095 SGTC_2592 piperlongumine 83.33 µM -2.0933708641099 0.0237568454573089 no 3250 0.0181580306127249 1069 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1226 3909-7979 35.4 µM -2.09531233570505 0.0236548046172647 no 3251 0.0180716183021842 1062 6615510 SGTC_1980 st071811 45.7 µM -2.09602080845841 0.0236176602573284 no 3252 0.0180401725487318 1072 4974850 SGTC_580 1123-0028 41 µM -2.09626274418007 0.0236049871046711 no 3253 0.0180294448573316 1072 1677248 YPR107C YTH1 SGTC_773 4358-1457 44.6 µM -2.1035784768068 0.0232244647977918 no 3254 0.0177076165334914 1080 1186886 SGTC_2521 angolensin 13.4 µM -2.11898726880275 0.0224398597170814 no 3255 0.0170457714465197 1062 821428 A flavenoid. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -2.13255698430895 0.0217675257758498 no 3256 0.0164805426010067 1071 16725076 SGTC_1410 3909-8106 77.9 µM -2.14078824441704 0.0213680458176818 no 3257 0.0161455591954191 1070 1039210 SGTC_1152 3909-8331 15.9 µM -2.15615964506461 0.020638626844576 no 3258 0.015535600720822 1063 16001939 SGTC_3202 9113761 49.47 µM -2.17000642427493 0.019999720261708 no 3259 0.0150031796376486 1064 4798415 SGTC_3213 9129884 49.47 µM -2.18076241464979 0.0195150776744412 no 3260 0.0146004969427065 1064 17190742 SGTC_2328 6201408 200 µM -2.18987952628839 0.0191121255467746 no 3261 0.0142664875889461 1062 2890418 SGTC_1455 4262-0120 131 µM -2.20115146254753 0.0186237353441056 no 3262 0.0138626515518086 1069 1529587 SGTC_2416 tofa 880 nM -2.2153887504225 0.0180220820770211 no 3263 0.013366696409776 1059 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_456 gingerol 170 µM -2.21678273076809 0.0179640746985541 no 3264 0.0133189710804274 1074 442793 A herb. SGTC_3264 9137442 49.47 µM -2.22549377170974 0.0176051785511141 no 3265 0.0130240543898614 1064 17015726 SGTC_1682 st012968 530 nM -2.22898494791783 0.0174630690759827 no 3266 0.012907453153651 1058 24207270 SGTC_1647 st011722 22.4 µM -2.23058739272274 0.0173981696935046 no 3267 0.0128542363367171 1068 2854783 SGTC_392 N-ethylmaleimide 8.33 µM -2.24698834246348 0.0167456864737521 no 3268 0.0123203860706068 1070 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2437 5741531 144.16 µM -2.24810049261841 0.0167022095675711 no 3269 0.0122848913411914 1056 2262990 SGTC_1724 st037281 8.293 µM -2.25009655145657 0.0166244205080869 no 3270 0.0122214084782777 1061 574124 YDL195W SEC31 SGTC_1008 4106-0037 6 µM -2.27444446964283 0.0157002333579494 no 3271 0.0114696381413531 1080 2905394 SGTC_70 0141-0289 43.283 µM -2.27512675478131 0.0156749834357588 no 3272 0.0114491635551621 1053 352408 SGTC_1735 st034310 56.75 µM -2.28877507023037 0.015177158889465 no 3273 0.0110462123319454 1073 871153 SGTC_1314 1222-0010 41.1 µM -2.29121461812846 0.015089621959161 no 3274 0.0109755019547865 1080 3526027 SGTC_1951 sophoraflavanone G 9.2 µM -2.29357687567719 0.01500527220967 no 3275 0.0109074074609933 1064 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2809 7964133 12.99 µM -2.29874927750235 0.0148219941020257 no 3276 0.0107595902837164 1083 1253665 SGTC_1047 2043-3044 82 µM -2.29952142240658 0.0147947998556438 no 3277 0.0107376741705622 1079 669592 SGTC_3004 9076122 71.4286 µM -2.30710910970759 0.014529843278355 no 3278 0.0105243691190987 1075 44782551 SGTC_2035 5154463 94.595 µM -2.30929975117833 0.0144541115338474 no 3279 0.0104634767311216 1074 2769623 SGTC_1071 trifluoperazine 6.31 µM -2.33550455999847 0.013574219300143 no 3280 0.0097585389836995 1084 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1855 st056195 39.6 µM -2.35584736443176 0.012923404710827 no 3281 0.00924025476697864 1057 4028379 SGTC_1384 3089-0840 101 µM -2.36382253721759 0.0126757219830543 no 3282 0.00904373723068951 1075 1069836 SGTC_934 2950-0684 338 µM -2.36485374513223 0.0126439979166659 no 3283 0.0090185962207735 1073 1121253 SGTC_1304 1165-0502 251 µM -2.38053871536642 0.012169870581692 no 3284 0.00864367218060536 1081 767425 SGTC_1305 1181-0477 144 µM -2.38633456325227 0.0119986135645496 no 3285 0.00850863097347265 1080 6252086 SGTC_3200 9114385 49.47 µM -2.38677583913228 0.0119856606834946 no 3286 0.0084984256560661 1066 17018030 YLR208W SEC13 SGTC_2111 5486399 200 µM -2.3931851018115 0.0117988907099069 no 3287 0.00835140608360323 1064 689674 SGTC_1040 k898-0338 155 µM -2.40803091808206 0.0113759473673867 no 3288 0.00801941132939638 1082 20969351 SGTC_43 0570-0105 72.5 µM -2.43062927558092 0.0107574364595158 no 3289 0.00753631398386151 1075 1114046 YDL195W SEC31 SGTC_58 0957-0393 9 µM -2.43507457052953 0.0106392773464937 no 3290 0.00744436050562249 1075 6997992 SGTC_2222 6885208 172.143 µM -2.43670877466342 0.0105961240760492 no 3291 0.00741080539796391 1088 609514 SGTC_1701 st028638 40.4 µM -2.44096675563878 0.0104844020474482 no 3292 0.00732400156669591 1085 3490878 SGTC_2890 9046729 58.44 µM -2.44517368012036 0.0103750291742916 no 3293 0.00723912006222899 1082 903329 SGTC_1133 3473-0247 50 µM -2.45620611848514 0.0100929163258318 no 3294 0.0070206297847876 1059 711311 SGTC_2190 6049624 200 µM -2.46292513379199 0.00992440243265581 no 3295 0.00689043439486857 1081 2265554 SGTC_1732 st034308 51.822 µM -2.48121377692954 0.0094781045319682 no 3296 0.00654679097420913 1067 830119 SGTC_2159 5658611 73.75 µM -2.48438158692025 0.00940261009791747 no 3297 0.00648883305392556 1078 793844 SGTC_2379 9035213 200 µM -2.49282393255733 0.00920397733956439 no 3298 0.0063365835712038 1081 646551 SGTC_35 0133-0054 64.071 µM -2.5149229636805 0.00870132109451432 no 3299 0.00595291978579967 1072 99677 SGTC_922 1866-0035 480 µM -2.52694736923678 0.00843806214021259 no 3300 0.00575293719217927 1064 3156169 SGTC_1559 coumarin 343 70.1 µM -2.53012892510571 0.00836958641190022 no 3301 0.00570103106794846 1082 108770 A hepatotoxic, DNA x-linker. SGTC_2636 apigenin dimethyl ether 100 µM -2.5312567976148 0.00834542892677996 no 3302 0.00568273022766735 1078 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_369 0957-0393 4.5 µM -2.53733778049981 0.00821623461211347 no 3303 0.00558495609325372 1078 6997992 SGTC_568 1193-0097 7.48 µM -2.54438968257177 0.00806861546662113 no 3304 0.0054734442082044 1044 3646150 SGTC_3174 9107204 49.47 µM -2.56441735332808 0.00766200860280648 no 3305 0.00516745945674129 1088 3938802 SGTC_881 0833-0569 170 µM -2.56889691647626 0.00757357126706516 no 3306 0.00510114005276356 1086 5418700 SGTC_916 4466-0038 42 nM -2.579700884331 0.00736396392328509 no 3307 0.00494429629142463 1081 5722064 YGL116W CDC20 SGTC_1685 st024049 53.0905 µM -2.62356348572954 0.00656458597620346 no 3308 0.00435076133119172 1085 1941139 SGTC_138 0850-0259 40.9225 µM -2.62679917172782 0.00650877636361296 no 3309 0.00430960936232299 1078 6813004 SGTC_351 caspofungin 25 nM -2.6405319803814 0.00627655390224612 no 3310 0.00413879899641033 1080 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_3141 9094609 49.47 µM -2.65752623616397 0.00599935637051408 no 3311 0.00393582316046609 1070 25236309 YDL196W YDL196W SGTC_157 1348-1695 65.819 µM -2.68842182526546 0.00552309647850091 no 3312 0.00358953216256521 1076 5380510 SGTC_1859 st055998 20 µM -2.68894496275862 0.00551533000190976 no 3313 0.00358391179725313 1083 676301 SGTC_854 0422-0053 192 µM -2.69298344878648 0.00545570066790598 no 3314 0.00354078922039972 1092 3596728 SGTC_1652 st011932 78 µM -2.71680266857829 0.00511551835110753 no 3315 0.00329579475112721 1080 1551076 SGTC_2715 st079500 56.4 µM -2.75173900861239 0.00465070039800127 no 3316 0.00296398721220408 1084 28246688 SGTC_1734 st037168 69.4 µM -2.76949523092725 0.00442921986852672 no 3317 0.00280716130980334 1084 708907 SGTC_1937 st074714 47.2 µM -2.80595759029826 0.00400371892244186 no 3318 0.00250836472949727 1089 17250970 SGTC_95 0471-0001 561.058 µM -2.81300689656054 0.00392581089740867 no 3319 0.00245402992493243 1089 4015405 SGTC_637 1181-0519 7.26 µM -2.8163629904176 0.00388919920093145 no 3320 0.00242853773612069 1077 6252091 YGR060W ERG25 SGTC_2722 naftopidil 47.16 µM -2.84497591007775 0.00358927265984652 no 3321 0.00222073909736855 1085 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2322 7413319 38.22 µM -2.85643722489621 0.00347507587760359 no 3322 0.00214212357068491 1068 1840400 SGTC_636 0kpi-0074 126 µM -2.8646009583971 0.00339573654608288 no 3323 0.0020876751657099 1092 616434 SGTC_9 0092-0002 10.449 µM -2.86561675230622 0.00338597928005071 no 3324 0.00208098884895702 1092 759368 SGTC_3188 9110789 49.47 µM -2.95656738925083 0.00260803244643174 no 3325 0.00155542122198835 1087 849217 SGTC_543 3844-1095 191 µM -2.99301389361215 0.0023445527513994 no 3326 0.00138118586793347 1087 4230703 SGTC_2756 carbadox 75.1 µM -3.03211618841345 0.00208887618975261 no 3327 0.00121422854642328 1068 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_2100 5377183 190 µM -3.03240796249066 0.00208706737465955 no 3328 0.00121305534690984 1080 2844202 SGTC_101 0490-5701 117.494 µM -3.05967458588403 0.00192417162938492 no 3329 0.00110788800494225 1089 4661669 SGTC_17 0960-0276 49.807 µM -3.1214474779618 0.00159701742631674 no 3330 0.000899821732866578 1094 6821114 SGTC_919 tnp00227 403.569 nM -3.19174576255394 0.00128692004661109 no 3331 0.000707078737500637 1088 1269246 A methoxyflavone. YNL221C POP1 SGTC_3208 9114115 49.47 µM -3.22063125805686 0.00117629205011237 no 3332 0.000639543025555388 1084 650895 SGTC_1204 4049-0315 18.3 µM -3.23294654810294 0.00113183048427168 no 3333 0.000612602424134863 1087 588402 SGTC_1838 st055369 84.5 µM -3.2658944350107 0.00102034203245995 no 3334 0.000545594599001616 1095 676036 SGTC_268 camptothecin 39.6153 µM -3.33931633361891 0.000807214831106877 yes 3335 0.000419924336227265 1094 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2981 9013952 38.96 µM -3.38884546048911 0.000687470410257573 yes 3336 0.000350937775718976 1089 2996344 SGTC_3197 9113331 49.47 µM -3.39955709031033 0.000663829575718689 yes 3337 0.000337475438604316 1085 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1283 0922-0125 16.4 µM -3.41167863833311 0.00063798299513862 yes 3338 0.00032282090414767 1090 3360884 SGTC_2250 alverine citrate 130 µM -3.42284521781416 0.000614997967279472 yes 3339 0.000309846765765648 1075 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_3131 9127911 49.47 µM -3.4357798721089 0.000589330693586635 yes 3340 0.000295425418220288 1091 45595681 SGTC_825 1988-2224 89.6 µM -3.55232359793904 0.000398861991153324 yes 3341 0.000190922475722747 1093 1180859 SGTC_41 0478-0632 82.643 µM -3.58059395459673 0.000362209459142838 yes 3342 0.000171407021900716 1088 3750424 SGTC_1493 4348-0038 111 µM -3.59731131266013 0.000342033705855338 yes 3343 0.000160761789119368 1093 800424 SGTC_22 0964-0034 14.468 µM -3.63837744090892 0.000296821894669226 yes 3344 0.000137180568371549 1095 138402 SGTC_1011 4112-3381 17.4 µM -3.74247789732276 0.000205910518070262 yes 3345 9.11072821378185e-05 1094 2877139 SGTC_1707 st032323 6.317 µM -3.75950071577894 0.00019379155222324 yes 3346 8.512639527334e-05 1089 3132057 YMR211W DML1 SGTC_828 2074-0507 139 µM -3.79179577003265 0.000172610735416569 yes 3347 7.47809436429149e-05 1094 X828 SGTC_809 3998-0021 90 µM -3.86511012733023 0.000132296813406937 yes 3348 5.55195434321358e-05 1089 715485 SGTC_586 0957-0265 8.15 µM -3.90491704809479 0.000114290254864081 yes 3349 4.71288555908756e-05 1086 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1067 clotrimazole 1.36 µM -3.97628631610611 8.76285364091498e-05 yes 3350 3.49999200396385e-05 1093 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2679 rapamycin 1 nM -4.13949263641357 4.69738761021333e-05 yes 3351 1.74037386249143e-05 1081 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_829 1635-0120 117 µM -4.53598523325142 9.40591463626091e-06 yes 3352 2.86675959545527e-06 1094 285054 SGTC_673 1082-0474 110 µM -4.87807650163505 2.11019380065344e-06 yes 3353 5.35626891472786e-07 1094 3098046 SGTC_1313 1220-0047 237 µM -5.56209575730997 7.88118450610945e-08 yes 3354 1.33276976335068e-08 1095 3528706 SGTC_1844 rapamycin 4 nM -7.71219166500357 1.86222843267691e-13 yes 3355 6.18376027703953e-15 1095 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3062 9077494 49.47 µM -8.65012902327885 1.86251929769873e-16 yes 3356 2.57206191731071e-18 1076 16459633