SGTCid condition conc unit GRS1|YBR121C.score GRS1|YBR121C.strain.pval GRS1|YBR121C.strain.significant GRS1|YBR121C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_3191 9110352 49.47 µM 5.39784576874296 3.04718554682951e-09 yes 1 3.37229031780205e-08 1 17122424 SGTC_1350 1495-0454 146 µM 4.25035621753643 2.41480982828284e-06 yes 2 1.06715404206596e-05 1 1069057 SGTC_1756 st041558 35.5 µM 4.12521010513337 4.56970428009387e-06 yes 3 1.8519823215517e-05 3 3955792 SGTC_3065 9113888 49.47 µM 4.09589114251377 5.29269931007755e-06 yes 4 2.10273760231219e-05 5 16648368 SGTC_3016 9080866 49.47 µM 3.98509962606118 9.13979828507608e-06 yes 5 3.37259097908988e-05 3 17066299 SGTC_1336 1486-0901 104 µM 3.90886152140995 1.32045545422451e-05 yes 6 4.63660488058761e-05 4 5006114 SGTC_771 0250-0039 27.3 µM 3.8561226977333 1.69669125530798e-05 yes 7 5.75998408827231e-05 2 3005115 SGTC_1527 coumarin 137 µM 3.80873770889845 2.11970347071123e-05 yes 8 6.98390134070654e-05 6 323 A hepatotoxic, DNA x-linker. SGTC_2566 crystal violet carbinol 226 nM 3.77031249946193 2.53435216053692e-05 yes 9 8.15216300202696e-05 22 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2316 5844804 197.44 µM 3.72690714677819 3.09494453389239e-05 yes 10 9.69219147980967e-05 12 776813 SGTC_587 k089-0003 57 µM 3.42352167246797 0.000117971042386028 yes 11 0.000309076612211943 2 9659696 SGTC_1189 1431-2119 7.28 µM 3.34234993552367 0.000165852639600725 yes 12 0.000415361299793646 15 3107275 SGTC_835 0312-0010 67.2 µM 3.26289799967496 0.000229861381759193 yes 13 0.000551396017098501 3 1626196 SGTC_3246 9135460 32.98 µM 3.22511947789118 0.00026779373898391 yes 14 0.0006296005309499 3 41446951 SGTC_1316 1272-0050 65.9 µM 3.19209840550336 0.0003056475272546 yes 15 0.000706216018035848 5 7340392 SGTC_2502 avocadyne acetate 18.59 µM 3.16820321153937 0.000336083030627995 yes 16 0.000766921336388695 11 3952079 SGTC_1299 1079-1439 3.74 µM 3.13010663754918 0.000390488613925412 yes 17 0.000873714282937844 9 323161 SGTC_2465 5809242 33.21 µM 3.12268298010206 0.000401999267958933 yes 18 0.000896053338046175 6 2731748 SGTC_2436 5633522 8.09 µM 3.10035970006592 0.000438536886746824 yes 19 0.000966428793115954 22 5724242 SGTC_1628 st004252 77.7 µM 3.09780001880574 0.000442917689807833 yes 20 0.000974814710945324 12 692968 SGTC_1981 st071826 47 µM 3.06726986103317 0.000498391761888754 yes 21 0.0010801186733606 14 11838600 SGTC_1733 st037357 54.9 µM 3.04064211054043 0.000551956596978958 yes 22 0.00118037127951105 17 1272339 YGL099W LSG1 SGTC_2110 5483698 200 µM 3.02814739556318 0.000578883984809694 yes 23 0.00123029020147624 16 2848765 YHR062C RPP1 SGTC_1965 Pectolinarigenin 58.4 µM 3.01732546626147 0.000603182163360946 yes 24 0.00127507923188383 10 5320438 An anti-inflammatory. SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 3.00901483939433 0.000622477610172253 yes 25 0.00131048156948928 10 6857784 SGTC_1288 0973-0013 65.5 µM 3.00158652061858 0.000640205325623478 yes 26 0.00134288352193058 8 4315430 SGTC_1121 fusaric acid 630.51 nM 2.99937234925159 0.000645578926575153 yes 27 0.00135268230492414 12 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_3014 9081533 49.47 µM 2.92573294280753 0.000849864650609455 yes 28 0.00171822897717659 21 21367265 SGTC_3151 9099821 49.47 µM 2.89682487421841 0.000945186208136974 yes 29 0.00188480058975002 18 17174189 SGTC_2047 4141938 200 µM 2.87281087119016 0.00103173300169889 no 30 0.00203418795689307 10 3807862 SGTC_282 k297-0036 65.7 µM 2.85353287161016 0.00110640778274624 no 31 0.00216180273035017 14 5061378 SGTC_2684 capsaicin 100 µM 2.84206493663672 0.00115314726396147 no 32 0.00224111804908419 12 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2338 7999974 200 µM 2.83761022944124 0.00117178578286461 no 33 0.00227263246760801 28 315925 SGTC_425 3825-7017 13.1 µM 2.80612732921634 0.0013115758387008 no 34 0.00250704373374159 26 3397440 SGTC_2769 toremifene 3.73 µM 2.79881928592207 0.00134613261958614 no 35 0.00256449167915219 23 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1059 3448-6867 171 µM 2.77898528248392 0.00144415441568519 no 36 0.00272644978153296 23 3934407 SGTC_3194 9111903 49.47 µM 2.7771740723233 0.00145342268047983 no 37 0.0027416901775592 14 17087251 SGTC_1942 st076330 65.2 µM 2.77050657874786 0.00148801105590922 no 38 0.00279845847823056 14 24208414 SGTC_2458 5808907 16.39 µM 2.75592025874913 0.00156631227179044 no 39 0.00292636318026597 22 2731747 SGTC_191 3914-0123 66.505 µM 2.74976028508029 0.00160049374629786 no 40 0.00298194381629669 17 3144412 SGTC_1781 st038725 66.3 µM 2.7388135079437 0.00166291880217652 no 41 0.00308306697403063 33 4270275 YIL048W NEO1 SGTC_1022 4477-0945 21.3 µM 2.70753226404404 0.00185371924203646 no 42 0.00338927408090581 20 4648966 SGTC_838 0109-0203 71.4 µM 2.687004525242 0.00198952609758218 no 43 0.0036047987998858 16 759422 SGTC_1057 3448-5381 134 µM 2.68194970475175 0.00202432507858044 no 44 0.00365972316194096 37 5497911 SGTC_184 1494-0393 24.714 µM 2.65857423305137 0.00219254416401619 no 45 0.00392360306074317 65 3090647 SGTC_177 1327-0068 8.361 µM 2.65445904446954 0.00222343766528637 no 46 0.00397178408976005 44 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3126 9127922 49.47 µM 2.60226298715895 0.00265099203882765 no 47 0.00463054021564996 62 45595682 SGTC_2511 berberine 10.47 µM 2.60139083860924 0.00265872765407708 no 48 0.00464233042854821 29 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_551 k048-0028 34.9 µM 2.5826870139431 0.00282960592500137 no 49 0.00490171070484218 33 6836383 SGTC_944 3370-0224 231 µM 2.56446209421289 0.00300557517471852 no 50 0.00516679329737518 20 4580514 SGTC_741 4582-0002 126 µM 2.54128150727955 0.00324361315892942 no 51 0.00552234767775167 15 2912688 SGTC_399 oxolinic acid 75 µM 2.47242593051886 0.00405388428571186 no 52 0.00670997599451673 22 4628 A DNA gyrase inhibitor. SGTC_2037 5169046 200 µM 2.47132334861954 0.00406821656756033 no 53 0.00673070200586758 22 5718022 SGTC_2839 9003951 25.97 µM 2.45301346441797 0.00431294588473849 no 54 0.00708325179597414 19 2990634 SGTC_187 1488-2104 32.728 µM 2.44501612612911 0.00442390678464597 no 55 0.00724228326525608 26 2852859 SGTC_2916 7875993 68.79 µM 2.43081795157747 0.00462719992399429 no 56 0.007532390876354 33 1299250 SGTC_2723 salbutamol 83.58 µM 2.42399398548615 0.00472784149325382 no 57 0.00767542986074663 12 9884233 β2-adrenoceptor agonist SGTC_2303 7774051 200 µM 2.39600393113785 0.00516137394616595 no 58 0.00828745627531349 40 2953184 SGTC_2019 4016004 108 µM 2.3944245015635 0.00518685987369439 no 59 0.00832323507104794 40 45595336 SGTC_279 1273-0055 2.93 µM 2.34852077140423 0.00597820103199959 no 60 0.00942407394542141 19 2847562 SGTC_2529 gangaleoidin 93.61 µM 2.34040567167511 0.00612872893155972 no 61 0.00963140186154251 23 4565183 SGTC_2296 7971656 126.45 µM 2.33257677988303 0.00627712063547169 no 62 0.00983518440788092 32 666570 SGTC_847 0342-0274 5.54 µM 2.32986065885617 0.00632934135775135 no 63 0.00990675845368982 31 18097 SGTC_2716 st080858 38.6235 µM 2.32855363099333 0.00635460733086879 no 64 0.0099413624733808 23 5296050 SGTC_1163 k060-0048 49.9 µM 2.32768642590566 0.00637142037695874 no 65 0.00996438022365472 24 6809982 SGTC_2442 5158906 48.48 µM 2.32485128213909 0.00642666215639079 no 66 0.0100399568817294 24 1893835 SGTC_2093 5331342 194.4 µM 2.31624598625056 0.00659693731454836 no 67 0.0102724208198563 36 33839 SGTC_1957 st077035 62.4 µM 2.31318625282747 0.00665843542522877 no 68 0.0103562005323829 22 705593 SGTC_2427 5545055 42.75 µM 2.30905004132055 0.00674237519862837 no 69 0.0104704022764886 31 5372858 SGTC_1198 1612-1005 86.7 µM 2.30770700754948 0.00676983094807824 no 70 0.0105077190317416 36 6998509 SGTC_3251 9135047 49.47 µM 2.30469125221504 0.00683184250272509 no 71 0.0105919355847331 21 17682963 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 2.30207026915284 0.00688614350453109 no 72 0.01066560487125 30 23665772 A membrane-active detergent. SGTC_1637 st007924 17.4 µM 2.29557503189631 0.00702235636703715 no 73 0.0108500958684513 27 683336 SGTC_346 4513-0042 7.16 µM 2.28899827329645 0.00716269640730224 no 74 0.0110397263557041 43 2827372 SGTC_2334 9017922 200 µM 2.28269415347617 0.00729953502202759 no 75 0.0112241952114919 31 3163164 SGTC_3315 9136395 68.55 µM 2.28006932562102 0.00735718632834306 no 76 0.0113017885785095 51 16876844 SGTC_3225 9130819 49.47 µM 2.27784926866112 0.00740626019097061 no 77 0.0113677798657063 52 4547121 SGTC_552 k242-0005 476 µM 2.27722968478181 0.00742000733843445 no 78 0.0113862566786218 35 4088318 SGTC_2419 paclitaxel 166.5 µM 2.27695085659536 0.00742620123018813 no 79 0.0113945802149408 40 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2412 st077135 33.4 µM 2.27158468598316 0.007546296179272 no 80 0.0115558033521043 38 13258915 SGTC_133 0724-0033 378.92 µM 2.26673982047745 0.00765619027459198 no 81 0.011703062158064 33 280309 SGTC_2625 euphol 100 µM 2.26258922185439 0.00775145459605738 no 82 0.0118305115784517 44 6708538 A triterpene alcohol. SGTC_480 am 92016 50 µM 2.25528216781471 0.00792170247387174 no 83 0.0120578115998362 40 2129 K+ channel blocker. SGTC_1149 3909-7961 23.3 µM 2.24893877620674 0.00807215550915895 no 84 0.012258195767655 41 735261 SGTC_1870 st057514 26.5 µM 2.22099161514527 0.00876531527116322 no 85 0.0131757646558901 39 5393161 SGTC_2782 7736369 71.43 µM 2.2070045391885 0.00913142740471877 no 86 0.0136568711107425 47 2950836 YOL077C BRX1 SGTC_58 0957-0393 9 µM 2.1997048622397 0.00932776129027695 no 87 0.0139139208050291 97 6997992 SGTC_1060 3448-7350 82 µM 2.18535522034147 0.00972450289199741 no 88 0.0144314057359431 52 570178 SGTC_1819 st053448 58.6 µM 2.18389031796426 0.00976582241374045 no 89 0.0144851543222223 42 2857616 SGTC_2448 5185112 27.17 µM 2.16352235541108 0.0103564182316071 no 90 0.0152505131015165 40 5718189 SGTC_2514 salinomycin 42.74 µM 2.15016822001357 0.0107603297959921 no 91 0.015770955485569 44 23682228 A polyether potassium ionophore. SGTC_3108 9121785 49.47 µM 2.14667935026924 0.0108680881922945 no 92 0.0159094089161192 50 17140271 SGTC_2913 7966556 36.57 µM 2.14312271707113 0.0109789050870518 no 93 0.0160516228908792 41 2976516 SGTC_720 r052-1644 49.9 µM 2.12557576173842 0.0115401351495017 no 94 0.0167692997917671 40 1422863 YOR257W CDC31 SGTC_3131 9127911 49.47 µM 2.12524764514873 0.0115508628286498 no 95 0.0167829771670649 37 45595681 SGTC_573 3702-0553 84.7 µM 2.12287684965342 0.011628632983096 no 96 0.0168820864296109 50 1222756 SGTC_2051 5263410 176 µM 2.110857887713 0.0120299283837102 no 97 0.0173922643530634 44 227584 SGTC_597 k018-0003 82.8 µM 2.09534639535957 0.0125655430641383 no 98 0.0180701054867755 37 6786234 SGTC_1150 3909-7983 10.9 µM 2.09191290443019 0.0126868544763679 no 99 0.0182231537564139 69 23965914 SGTC_3080 9117754 49.47 µM 2.08612607256655 0.0128936076902163 no 100 0.0184836022697053 49 9550191 SGTC_591 4299-0174 154 µM 2.07880174477618 0.013159465892893 no 101 0.018817788234874 30 5509088 SGTC_32 0928-0142 34.1 µM 2.06533059611789 0.0136608237103703 no 102 0.0194458652553627 49 2244242 SGTC_2875 9039966 71.43 µM 2.06348171937323 0.0137309037995964 no 103 0.0195334414410353 28 6463691 SGTC_1412 3909-8563 178 µM 2.05204893911364 0.0141711788929982 no 104 0.020082453263672 37 23767530 SGTC_906 1165-0455 526 µM 2.05093839833369 0.0142145867826939 no 105 0.0201364730752351 38 3252859 SGTC_2812 7970281 58.44 µM 2.05068327163802 0.0142245751258906 no 106 0.0201489005434655 52 2233435 SGTC_2556 citropten 84.59 µM 2.04376220361613 0.0144978547289472 no 107 0.0204885223763156 41 2775 A potential DNA crosslinker. SGTC_2162 5663267 200 µM 2.0396805072822 0.014661130345346 no 108 0.0206910788173442 62 6456493 SGTC_1564 D-Arginine 115 µM 2.0391575769715 0.0146821624480383 no 109 0.0207171516712841 70 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_843 0310-0051 143 µM 2.03783415903264 0.0147355059319895 no 110 0.020783260480681 39 2065037 SGTC_1109 tnp00067 928.257 nM 2.03538543438491 0.0148346472541665 no 111 0.0209060528822443 35 676295 SGTC_852 0418-0143 439 µM 2.03310027112312 0.0149276833568928 no 112 0.0210211968118667 60 5369229 SGTC_1365 1672-3266 55.4 µM 2.0330896610704 0.014928116492408 no 113 0.0210217326762418 59 6415873 SGTC_1153 4055-0057 267 µM 2.02944396271878 0.0150775864198104 no 114 0.0212065455805337 61 882706 SGTC_1881 5652484 16 µM 2.02942592975973 0.0150783289376943 no 115 0.0212074631376105 51 2255129 SGTC_2279 7948423 32.93 µM 2.02927914056138 0.0150843742398578 no 116 0.0212149333478733 49 1247112 SGTC_1352 1496-0991 99 µM 2.02374254055595 0.0153139169549907 no 117 0.0214983245308894 45 3000039 SGTC_1880 MG-132 525 µM 2.0232550379656 0.0153342713398601 no 118 0.0215234299425355 58 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2876 9059903 25.97 µM 2.01956591916518 0.0154890552110628 no 119 0.0217142166246679 46 6916095 SGTC_533 1222-0222 6.71 µM 2.01607228098945 0.015636871818329 no 120 0.0218962090374171 56 3982874 SGTC_2488 5268135 45.7 µM 2.01405438449225 0.0157227996781724 no 121 0.0220019119849554 71 1270356 YLR208W SEC13 SGTC_1210 3013-0140 750 nM 2.00263251459991 0.0162168488562778 no 122 0.0226083736128747 41 905973 SGTC_186 3455-3465 67.277 µM 2.0003847611629 0.0163156251673435 no 123 0.022729366312465 41 755278 SGTC_2714 st079313 56.9 µM 1.99612779919837 0.0165041075450297 no 124 0.0229600069176082 39 2939799 SGTC_752 1896-0090 130 µM 1.99293832797252 0.0166465439947278 no 125 0.0231341003426031 48 772567 SGTC_1296 1068-0102 11.9 µM 1.99232094011985 0.0166742366774238 no 126 0.0231679277898485 30 767053 SGTC_1640 st009078 66.4 µM 1.99163919883869 0.0167048616921119 no 127 0.0232053296132917 43 690618 SGTC_2572 astragaloside iv 100 µM 1.98662920115393 0.0169313992729341 no 128 0.0234817513851354 54 45006101 An anti-inflammatory agent. SGTC_2851 9015922 71.43 µM 1.9853878186487 0.0169879353525251 no 129 0.0235506700966595 55 2996893 SGTC_2962 9082311 13.18 µM 1.98273749391123 0.0171091789459308 no 130 0.0236983795909131 66 16459453 SGTC_1476 4112-3294 3.34 µM 1.98262505512481 0.0171143389596171 no 131 0.0237046632841521 39 704369 SGTC_1711 st032263 62.8 µM 1.97085745180856 0.0176617790432146 no 132 0.024370091524565 45 3958979 SGTC_1199 1638-0010 4.46 µM 1.96224752103298 0.0180717264459874 no 133 0.0248668368841179 47 3111136 SGTC_1439 4092-1168 46 µM 1.94909797625046 0.0187134625096683 no 134 0.0256418626591102 47 2886240 SGTC_1859 st055998 20 µM 1.94757438383498 0.0187890570922308 no 135 0.0257329556678451 59 676301 SGTC_1653 st012112 65 µM 1.94558209511483 0.018888298429669 no 136 0.0258524797498777 34 720429 SGTC_949 1165-0505 146 µM 1.94457822422772 0.0189384727017112 no 137 0.0259128811245036 41 6244267 SGTC_1147 3809-1045 12.3 µM 1.94108109834975 0.019114148149698 no 138 0.0261242206713199 65 325925 SGTC_3250 9135583 49.47 µM 1.93859442240023 0.0192399056116753 no 139 0.0262753716276078 43 7699353 SGTC_2069 5228469 200 µM 1.93134250475476 0.0196106762691925 no 140 0.0267203551343587 55 2835210 SGTC_2449 5812982 45.77 µM 1.92493943416033 0.0199430742836466 no 141 0.0271184678797737 35 776185 SGTC_1960 st011366 51.8 µM 1.91315031180478 0.0205675836759109 no 142 0.0278644062185777 59 3972846 SGTC_1426 4048-4480 71.7 µM 1.9090604163408 0.020788074878887 no 143 0.0281271491609732 41 14224343 SGTC_2569 tetrandrine 100 µM 1.90551036738957 0.0209810817094794 no 144 0.0283568805471813 53 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1555 citronellol 128 µM 1.89189250030883 0.0217355746901569 no 145 0.0292526526164618 43 8842 A terpine precursor. SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.88936756317605 0.0218779575344778 no 146 0.0294212970636163 79 6708760 SGTC_3197 9113331 49.47 µM 1.88044672138649 0.0223873327704111 no 147 0.030023610553111 73 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2641 levomentholum 100 µM 1.87977557581319 0.0224260561342143 no 148 0.0300693352521396 41 16666 SGTC_2272 7805186 180 µM 1.87833342059772 0.0225094558962929 no 149 0.0301677836699118 56 2956062 YPR165W RHO1 SGTC_3188 9110789 49.47 µM 1.87209582113855 0.022873193850021 no 150 0.0305966740210175 64 849217 SGTC_873 0591-4978 488 µM 1.86043813293535 0.0235662787805455 no 151 0.0314117819108844 65 3305145 SGTC_757 1066-0008 322 µM 1.85711123392116 0.0237672831527155 no 152 0.0316476651325885 58 6842497 SGTC_647 0140-0236 81 µM 1.85219304471688 0.0240670690887753 no 153 0.0319990535945 53 990837 SGTC_536 3852-0578 10.6 µM 1.85028136168485 0.0241844491744796 no 154 0.032136503777603 60 2869208 SGTC_1065 prochlorperazine maleate 2.48 µM 1.83471259222586 0.0251584140798758 no 155 0.0332741427606457 75 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_2516 gossypol 71.55 µM 1.81874176799404 0.0261914747686197 no 156 0.0344754181052627 70 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2305 7443522 69.23 µM 1.81734720982303 0.0262833407376309 no 157 0.0345819827392085 69 5415886 SGTC_1502 4534-4282 27.7 µM 1.81618866183793 0.0263598643280709 no 158 0.0346707183685359 48 3278949 SGTC_411 enrofloxacin 100 µM 1.81369933529558 0.0265249176155875 no 159 0.0348620137413603 49 71188 A bacterial gyrase inhibitor. SGTC_2438 5259590 200 µM 1.81365660125409 0.0265277585921728 no 160 0.0348653052414264 70 1201127 SGTC_1843 st055809 45.5 µM 1.80730175432815 0.026953070460001 no 161 0.0353576213312364 65 16413835 SGTC_1184 1269-1718 139 µM 1.80517916296066 0.0270963915009799 no 162 0.0355233252474758 70 5403821 SGTC_1958 st076513 41.9 µM 1.80430077016601 0.0271558878627913 no 163 0.0355920845635442 57 732122 YGL099W LSG1 SGTC_590 k048-0076 22.4 µM 1.79791831081665 0.0275914735831355 no 164 0.0360949769818742 65 6832814 SGTC_3195 9113082 49.47 µM 1.79460980088535 0.0278195528706366 no 165 0.03635794525709 46 17018038 SGTC_2906 7926292 26.41 µM 1.78269717028752 0.0286538241505364 no 166 0.0373178061167747 56 2966319 SGTC_2006 4011487 200 µM 1.77716961249937 0.0290479422182201 no 167 0.0377701687551584 90 45595294 SGTC_804 1595-0054 20.9 µM 1.7759875403671 0.0291328066739057 no 168 0.0378674854051707 61 761523 Stimulates phospholipase C. SGTC_3345 9148410 3.559 µM 1.77201286271421 0.0294196725991849 no 169 0.038196211035598 54 4903596 SGTC_2735 sertaconazole 140 nM 1.76805578261126 0.0297075942913269 no 170 0.0385257892804917 69 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2058 5236698 133 µM 1.75859858069726 0.0304051923301393 no 171 0.0393228571171071 60 766665 SGTC_1522 st012842 45.6 µM 1.7516488098502 0.0309264396002417 no 172 0.0399171070701115 80 3491067 YOR116C RPO31 SGTC_3032 9089427 49.47 µM 1.74195479504391 0.0316658434623536 no 173 0.0407581773084122 61 17173707 SGTC_2963 9082507 9 µM 1.74023913383349 0.031798213709588 no 174 0.0409085183354084 80 16459611 SGTC_868 0527-0199 213 µM 1.73901708655666 0.0318927781290912 no 175 0.0410158787397085 68 2849450 SGTC_3347 9188721 44.724 µM 1.73463156394823 0.0322340528657177 no 176 0.0414030425140597 73 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_3266 9136860 49.47 µM 1.73008014763196 0.0325914188587682 no 177 0.0418079783117228 88 4871271 YPR165W RHO1 SGTC_1688 st021091 57.6 µM 1.72521977196669 0.0329766450620526 no 178 0.0422439368921868 70 3656366 SGTC_76 0433-0009 400.328 µM 1.71612314382693 0.0337077130346687 no 179 0.0430697530534909 61 2841569 SGTC_1207 2099-0101 141 µM 1.7139025783453 0.0338881838545123 no 180 0.043273309729578 72 5837381 SGTC_2595 hexamethylquercetagetin 100 µM 1.70480657724638 0.0346357526442822 no 181 0.0441152522212102 85 386331 SGTC_1865 st057639 52.2 µM 1.70310088729812 0.0347774345000033 no 182 0.0442745949654396 75 688818 SGTC_2023 5144124 124 µM 1.70255238316852 0.0348230965759875 no 183 0.0443259337768765 72 2830192 SGTC_189 3970-0742 2.116 µM 1.70137767670835 0.0349210545775232 no 184 0.0444360451865569 61 2891807 SGTC_1297 1068-0111 14.1 µM 1.69960928182106 0.0350689463192456 no 185 0.044602221648512 80 767057 SGTC_2297 7971671 152.32 µM 1.69929846315377 0.0350949932700928 no 186 0.0446314810055359 76 909016 SGTC_2420 aureobasidin a 50 nM 1.69780832715108 0.0352200889055751 no 187 0.0447719718741877 54 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_663 1486-0733 13.9 µM 1.69359875827253 0.0355754560401424 no 188 0.0451707770898581 81 722445 YPR165W RHO1 SGTC_2236 dapsone 200 µM 1.69174558317014 0.0357328281727844 no 189 0.0453472465645412 45 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1072 oxiconazole 14.9 nM 1.68755280402923 0.0360909861842066 no 190 0.0457485527534294 91 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1829 berberine 14.4 µM 1.68316480999175 0.0364689628693958 no 191 0.0461715955093251 100 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_613 3914-0030 117 µM 1.68051805647897 0.0366985131309406 no 192 0.0464282820811382 36 1145395 SGTC_1842 st055362 61.2 µM 1.68049482625445 0.0367005330845952 no 193 0.0464305400478628 58 676032 SGTC_281 1672-3440 14.9 µM 1.67876551145883 0.0368511589319265 no 194 0.0465988762998163 64 6833000 SGTC_759 3486-0358 89.3 µM 1.6764929069878 0.0370498743545049 no 195 0.0468208422011066 88 875103 SGTC_3185 9108267 49.47 µM 1.67542655059248 0.0371434174746729 no 196 0.0469252854576821 63 4910486 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 1.67056618559184 0.0375722269573294 no 197 0.0474036981010464 71 75037 A free radical scavenger. SGTC_2553 4-methylesculetin 85.09 µM 1.66943076982295 0.0376729801413776 no 198 0.0475160199368059 61 5319502 SGTC_2492 derrusnin 100 µM 1.66608335696256 0.037971303174868 no 199 0.0478484064649903 84 1715307 Part of coumarin class of compounds. SGTC_453 enantio-paf c16 10 µM 1.6643175744919 0.0381294453893179 no 200 0.0480244910715945 113 13871343 A lipid and platelet activating factor SGTC_760 0568-0725 82.9 µM 1.66079719786019 0.038446330851141 no 201 0.0483770920719639 71 3916171 SGTC_535 2293-4129 48.2 µM 1.6605428360988 0.0384693100448755 no 202 0.0484026489512931 98 396118 YIL048W NEO1 SGTC_1333 1482-0047 286 µM 1.65477517556981 0.0389933756098803 no 203 0.048985055663938 76 3811116 SGTC_2750 bromebric acid 70.15 µM 1.65111457922476 0.0393289926507233 no 204 0.04935759044261 82 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2180 6301957 200 µM 1.64865785461409 0.0395555495617223 no 205 0.0496088744789329 72 845462 SGTC_1143 3454-2408 5.08 µM 1.64588341003889 0.039812681392747 no 206 0.0498938825790622 70 X1143 SGTC_392 N-ethylmaleimide 8.33 µM 1.64550009882161 0.0398483127602965 no 207 0.0499333611508738 95 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1864 st057645 30.4 µM 1.64461076564528 0.0399310821325043 no 208 0.0500250526596664 74 688666 SGTC_1780 st038448 24.544 µM 1.64431301944448 0.0399588242823737 no 209 0.0500557806956952 76 728868 YDL195W SEC31 SGTC_2989 9073649 71.4286 µM 1.64315549606065 0.0400668240042048 no 210 0.0501753825558483 90 21367202 SGTC_1443 4112-3303 14 µM 1.64019108578295 0.0403444923929959 no 211 0.0504827210993324 91 704433 SGTC_534 k292-0788 63.4 µM 1.63404047126904 0.0409255889745514 no 212 0.0511251764721746 100 4146317 SGTC_2039 Aminomethylbenzodioxan 200 µM 1.63316254295766 0.0410090847052779 no 213 0.0512174077690763 84 15053 SGTC_326 k292-0812 17.5 µM 1.63287115706158 0.0410368275978809 no 214 0.051248048737427 79 3579357 SGTC_280 3448-3607 3.04 µM 1.63095944807873 0.041219219403623 no 215 0.051449438232434 51 626179 SGTC_2856 9022925 19.48 µM 1.6256427123225 0.0417299346706325 no 216 0.0520128417068366 83 4944862 SGTC_1486 3970-0793 4.53 µM 1.62236154795425 0.042047666158351 no 217 0.0523629786592845 90 2844330 SGTC_550 4123-0385 25.7 µM 1.62015366615082 0.0422625664005048 no 218 0.0525996358303396 75 5731123 SGTC_2326 6164455 177.58 µM 1.61289037856292 0.0429758027699925 no 219 0.053384162940977 98 2888790 SGTC_1975 st070967 30.8 µM 1.60911983901947 0.043349877183184 no 220 0.0537950700047544 113 261391 SGTC_1082 camptothecin 424.86 nM 1.60885586033298 0.0433761646179117 no 221 0.0538239315151749 104 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2793 7325131 81.82 µM 1.60782527429499 0.0434789153093454 no 222 0.0539367256944001 81 4176441 SGTC_520 3584-0023 682 µM 1.6051735135991 0.043744202449218 no 223 0.0542278123156766 95 1340790 SGTC_356 1634-0012 32.5 µM 1.60142304215737 0.044121634725177 no 224 0.0546416262886559 103 735457 SGTC_2077 5212015 200 µM 1.6013656171933 0.0441274340848538 no 225 0.0546479817130934 81 780900 SGTC_2319 6033012 152.6 µM 1.59957220339024 0.0443088608450963 no 226 0.0548467594985359 81 847246 SGTC_1934 st074720 32.6 µM 1.59582993282439 0.0446893754199331 no 227 0.0552633842044082 100 17250992 SGTC_2571 chrysanthemic acid 100 µM 1.59025642016789 0.045260964927678 no 228 0.0558885087787197 88 2743 An insecticide. SGTC_918 glabranin 770.725 nM 1.58470599621586 0.0458360169529327 no 229 0.0565165744395301 85 124049 Also referred to as licorice root. SGTC_1433 4060-0023 7.6 µM 1.5749586896853 0.046860084701938 no 230 0.0576329901178014 95 3840627 SGTC_1963 st076565 50.3 µM 1.57103452839763 0.0472775101846759 no 231 0.0580873143765595 104 4914280 SGTC_1007 4101-0031 70 µM 1.56901015527608 0.0474940114950293 no 232 0.0583227863745809 97 1146276 SGTC_439 amiodarone 34.4 µM 1.56270302823826 0.0481736380247963 no 233 0.0590612309058474 93 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_3175 9106517 49.47 µM 1.56247550102766 0.0481982999606189 no 234 0.059088006443679 83 41468073 SGTC_1231 0242-0792 125 µM 1.55820753017158 0.0486627848341223 no 235 0.0595920302576789 78 3707635 SGTC_3217 9129673 49.47 µM 1.55806097900257 0.0486787973748331 no 236 0.059609396790176 91 17248312 SGTC_2955 9076254 12.21 µM 1.55642691486117 0.0488576246803835 no 237 0.0598033045922549 82 16459619 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.55062901650127 0.0494963694917858 no 238 0.0604953071526409 103 442882 SGTC_1260 0700-1617 7.75 µM 1.54887373899166 0.0496910544163589 no 239 0.0607060374762493 95 2853078 SGTC_3165 9101544 49.47 µM 1.54782833200525 0.0498072947290829 no 240 0.0608318166292506 89 5002184 SGTC_2729 fluphenazine 10.66 µM 1.54273998842073 0.050376175505029 no 241 0.0614469376482477 98 3372 An atypical antipsychotic. SGTC_963 1269-2853 151 µM 1.53582152144324 0.05115795793881 no 242 0.062291079934198 83 3668223 SGTC_1945 st075991 56.6 µM 1.533972872997 0.0513684803034893 no 243 0.0625181632632212 104 1084980 SGTC_2905 7799065 20.05 µM 1.52514248504596 0.052383600231472 no 244 0.0636117812148164 96 1296806 SGTC_3288 9119690 36.221 µM 1.52447494188896 0.0524609823483298 no 245 0.0636950559103503 115 17595618 YKL019W RAM2 SGTC_1779 st039427 55 µM 1.52350523389112 0.0525735532669213 no 246 0.0638161761317522 82 1124498 SGTC_726 3448-4391 34.2 µM 1.52189851769967 0.052760494733617 no 247 0.0640172553296437 89 1356692 SGTC_3201 9113999 49.47 µM 1.51902207316783 0.0530964860048076 no 248 0.064378470000225 92 16649224 SGTC_542 3381-0244 89.3 µM 1.51793835236751 0.0532235122358473 no 249 0.0645149701943726 93 1112843 SGTC_1134 3477-0009 42.5 µM 1.51741110225259 0.0532853998879775 no 250 0.06458146130276 112 3973534 SGTC_1901 st060216 58.6 µM 1.51185554624716 0.0539409732357804 no 251 0.065285307502223 88 688792 SGTC_1238 0333-0287 48.8 µM 1.50629147956834 0.0546039346886775 no 252 0.0659961822264652 85 7226 SGTC_2264 7948757 110.76 µM 1.50577518815211 0.0546657763288223 no 253 0.0660624474114382 67 2971411 SGTC_3068 9116768 49.47 µM 1.50404445522518 0.0548734884126097 no 254 0.0662849603150978 106 41904888 SGTC_877 0771-0151 33.1 µM 1.49660409092113 0.0557735493356268 no 255 0.0672481525207172 93 6166523 SGTC_2421 5690543 90.72 µM 1.49472041682218 0.0560032554359828 no 256 0.0674937117842574 102 3397993 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.49305388024954 0.0562071040744714 no 257 0.067711541806971 89 61125 An anti-inflammatory. SGTC_2355 9061122 103.12 µM 1.49198639638588 0.0563379844309814 no 258 0.0678513558076109 99 5302957 SGTC_3121 9125696 49.47 µM 1.48748846234965 0.0568921004645778 no 259 0.0684429241145908 73 1235365 SGTC_2181 6316240 54.2555 µM 1.48714111864264 0.056935068821001 no 260 0.0684887717502124 74 12779990 SGTC_3092 9117248 49.47 µM 1.48498831566575 0.0572019528318706 no 261 0.0687734596553562 87 17141857 SGTC_345 1362-0200 395 µM 1.47684382710383 0.0582205469121682 no 262 0.069858752667223 97 1419823 SGTC_946 3434-1334 87.4 µM 1.46902363118898 0.0592119404522624 no 263 0.0709131898715615 114 4047976 SGTC_820 1582-0060 59.9 µM 1.46687006329871 0.0594872678056975 no 264 0.0712057028236532 115 3848840 SGTC_54 0159-0055 9 µM 1.46440883216999 0.0598031566582989 no 265 0.0715411381680819 98 3319099 SGTC_1683 st010134 710 nM 1.46356324169578 0.059911987483076 no 266 0.0716566611065909 96 3818134 SGTC_1884 5633444 25 µM 1.46237841310516 0.0600647404687017 no 267 0.0718187707806318 100 5724239 SGTC_2082 5219693 150 µM 1.4613590648145 0.0601964029468429 no 268 0.071958464203171 92 2834649 SGTC_1498 4478-3555 97.6 µM 1.46007401474722 0.060362706183351 no 269 0.072134866665003 65 3437919 SGTC_903 1134-0042 114 µM 1.45813503681295 0.0606143170319633 no 270 0.0724016628221125 90 701009 SGTC_2833 9001315 45.46 µM 1.45772821176958 0.0606672125329659 no 271 0.0724577362692917 105 2989378 SGTC_2703 st077852 53.4 µM 1.45258560494002 0.0613389726859983 no 272 0.0731694226083984 113 6281836 SGTC_2287 7945887 168.79 µM 1.44590390866644 0.0622204420280032 no 273 0.0741020777398636 114 1245853 SGTC_3116 9124943 49.47 µM 1.44514745174239 0.0623208555825334 no 274 0.0742082364072645 99 41905195 YPL160W CDC60 SGTC_1631 benzylvanillin 81.9 µM 1.44508995323946 0.0623284932101869 no 275 0.0742163103049174 105 75506 SGTC_1006 4099-6547 255 µM 1.44171595342813 0.0627779470604924 no 276 0.0746912605944915 106 3146833 SGTC_2731 amoxapine 43.43 µM 1.44006758726762 0.0629984439239424 no 277 0.0749241391070517 99 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2270 7924575 90.91 µM 1.43812510073836 0.063259058159232 no 278 0.0751992809174669 107 1262135 SGTC_2386 9075165 157.42 µM 1.43496166335795 0.0636852772836327 no 279 0.0756490111681268 108 16452277 SGTC_1490 4089-0339 670 nM 1.43368285572851 0.0638582075709764 no 280 0.0758313934164265 107 742542 SGTC_1840 st055363 71 µM 1.43337117399352 0.0639004108970017 no 281 0.0758758958647832 90 676033 SGTC_77 0828-0286 12.516 µM 1.43206559933509 0.0640774282581589 no 282 0.0760625242001895 99 745345 SGTC_3087 9117406 49.47 µM 1.43003002197219 0.0643541839108131 no 283 0.0763542013395941 102 42546093 SGTC_426 0988-0037 14.6 µM 1.42756527335927 0.0646905316185477 no 284 0.0767085124854249 131 5383008 SGTC_1692 fluoroquinolonic acid 71 µM 1.42438467223199 0.0651265825952916 no 285 0.0771675743960534 94 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1170 0310-0127 64.8 µM 1.42431861460359 0.0651356630184231 no 286 0.0771771306918559 112 774975 SGTC_811 0416-0114 265 µM 1.42067296043537 0.0656383274055368 no 287 0.0777059284236546 101 6612453 SGTC_876 0720-0963 56.8 µM 1.41917486533956 0.0658457552104777 no 288 0.077924020915327 102 765861 SGTC_2281 7943571 200 µM 1.41816067875287 0.0659864686794186 no 289 0.0780719295225472 113 1244024 SGTC_2118 5526350 200 µM 1.41694687569721 0.0661551841404825 no 290 0.0782492299996358 117 743594 SGTC_648 0375-0473 33.3 µM 1.41434743010414 0.0665176241854476 no 291 0.0786299586001034 117 1713139 SGTC_2807 7945238 51.95 µM 1.40360712935759 0.0680314576453817 no 292 0.0802179354838382 119 17148797 SGTC_622 1348-1566 26.3 µM 1.40249070311736 0.068190330671812 no 293 0.080384382392576 110 7340407 SGTC_2642 cholecalciferol 100 µM 1.4009873403769 0.0684047189433557 no 294 0.0806089294106847 80 9821465 A vitamin D precursor, similar to steriods. SGTC_181 1447-1644 8.07 µM 1.40022810048358 0.068513188423498 no 295 0.0807225117793764 126 534600 SGTC_1436 4092-1007 8.32 µM 1.39918042203702 0.0686630837393464 no 296 0.0808794429794427 91 2881121 SGTC_962 1254-0300 21.5 µM 1.39719545723611 0.0689477735207039 no 297 0.0811774012147526 98 7340576 SGTC_3052 9092717 49.47 µM 1.39696374096396 0.0689810662030948 no 298 0.0812122374965551 105 25237534 SGTC_3178 9107506 49.47 µM 1.39332663014835 0.0695052664934532 no 299 0.0817605206503742 132 8897194 SGTC_2762 leflunomide 42.06 µM 1.38887472956452 0.0701510677643756 no 300 0.0824354230381942 134 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1152 3909-8331 15.9 µM 1.38688538308346 0.0704411339745252 no 301 0.0827383578247516 97 16001939 SGTC_1752 st044819 83.042 µM 1.38307748582735 0.0709989333513392 no 302 0.0833205541090503 112 441209 YML126C ERG13 SGTC_1904 st060225 78 µM 1.38004449716745 0.0714456425427167 no 303 0.0837864723626408 103 66595 SGTC_3109 9122853 49.47 µM 1.37995916409773 0.0714582418218211 no 304 0.0837996092093451 136 1234709 SGTC_2537 larixol 68.93 µM 1.37965573033023 0.0715030571009922 no 305 0.0838463347316831 126 6708759 SGTC_1286 0929-0070 131 µM 1.3777047135735 0.0717917254700561 no 306 0.0841472377341383 114 1420408 SGTC_2930 9013230 14.89 µM 1.3751336690555 0.0721734958828553 no 307 0.0845450039123135 122 2995857 SGTC_1030 k029-0042 36.7 µM 1.37089520377593 0.0728062534539 no 308 0.0852038133530474 110 6080581 SGTC_2002 4023503 131 µM 1.36904327772308 0.0730840559396245 no 309 0.0854928736244494 130 4736863 YCR052W RSC6 SGTC_1747 st037496 66.6 µM 1.36569031402373 0.073589087917406 no 310 0.0860180928863125 140 723305 SGTC_1728 st035614 33.7865 µM 1.36439331705145 0.0737851590738349 no 311 0.086221905048918 135 15945546 SGTC_2981 9013952 38.96 µM 1.3635076617377 0.0739192756542382 no 312 0.0863612857247258 102 2996344 SGTC_966 1300-0360 30.2 µM 1.36175415191339 0.0741853626207867 no 313 0.0866377425757697 144 70588 SGTC_2482 5981709 142.65 µM 1.35898325825522 0.0746073234116803 no 314 0.0870759469456507 137 877755 SGTC_2133 5320837 200 µM 1.35686875119341 0.0749305579272204 no 315 0.0874114587377006 88 2841355 SGTC_2188 6126565 140.678 µM 1.35658673808125 0.0749737485270047 no 316 0.0874562789833844 104 874518 SGTC_2429 5902844 64.44 µM 1.35552547199681 0.0751364527211917 no 317 0.087625099365126 130 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_406 estrone 100 µM 1.35536174181223 0.0751615783808605 no 318 0.0876511662997617 114 5870 A steroid. SGTC_2395 5646831 180.19 µM 1.35118379172679 0.0758048866649458 no 319 0.0883182826546717 130 6808628 SGTC_1690 st023502 41.2 µM 1.35016483023018 0.0759624176031739 no 320 0.0884815583578233 125 24207482 SGTC_1468 k284-1086 134 µM 1.34960810099539 0.0760485929003697 no 321 0.088570862131968 131 15996457 SGTC_983 1491-0821 12.2 µM 1.34941556282246 0.076078412914517 no 322 0.0886017623985415 106 46495113 SGTC_744 1594-0068 283 µM 1.34902112427379 0.0761395307423519 no 323 0.0886650905373175 124 668392 SGTC_382 3229-0966 23.2 µM 1.34724714983913 0.0764148682763442 no 324 0.0889503235686236 116 5722370 SGTC_2234 tolnaftate 200 µM 1.34651810139812 0.0765282428435444 no 325 0.0890677433348357 107 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_616 4092-0450 108 µM 1.34585480168684 0.0766315039273053 no 326 0.0891746738723763 115 787165 SGTC_451 chloral hydrate 100 µM 1.34576492833733 0.0766455033664491 no 327 0.0891891696994833 139 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1356 1502-0781 85.8 µM 1.34549897361509 0.0766869421355536 no 328 0.0892320762656862 130 567702 SGTC_1368 1852-0141 284 µM 1.33916962162812 0.0776781619933857 no 329 0.0902577297767092 120 2838987 SGTC_3107 9121808 49.47 µM 1.33625853323768 0.0781373108585071 no 330 0.0907323925384752 94 662681 SGTC_3353 9151644 39.2805 µM 1.3354062201684 0.0782721300395807 no 331 0.0908717150305502 119 4909158 SGTC_1167 k781-0610 148 µM 1.33469804231503 0.0783842839848269 no 332 0.0909875972880482 135 4525169 SGTC_958 1222-0007 33 µM 1.33421312838483 0.0784611499330832 no 333 0.0910670090927865 133 7312461 SGTC_2206 7254556 146.969 µM 1.3277047037163 0.079498368274804 no 334 0.0921378395233784 100 4398905 SGTC_641 4092-0595 30 µM 1.32705793324361 0.0796020053256719 no 335 0.0922447596818089 129 786260 SGTC_3243 9134147 49.47 µM 1.32451231315411 0.0800109028927867 no 336 0.0926664782216603 109 24282180 SGTC_2273 7815444 169.05 µM 1.32092021212263 0.080590593345263 no 337 0.0932639847858868 136 2824616 SGTC_2284 7945075 39.21 µM 1.31986059070565 0.0807621986826019 no 338 0.0934407837100312 123 1245402 SGTC_1608 st001473 40.5 µM 1.31509077292007 0.0815380868901067 no 339 0.094239698633417 152 7292267 SGTC_3089 9117425 49.47 µM 1.31129631471145 0.0821593209614143 no 340 0.0948788364936167 104 9401657 SGTC_2656 pseudo-anisatin 100 µM 1.31064984277335 0.082265516785329 no 341 0.0949880457760992 113 6708809 A neurotoxin. SGTC_2629 bisabolol 100 µM 1.30880922359466 0.0825684411099392 no 342 0.0952994908973314 161 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2824 7998404 51.95 µM 1.30531049057355 0.0831465672082277 no 343 0.0958935716640863 132 837851 SGTC_324 1315-0088 19.6 µM 1.30260534545597 0.0835956444423467 no 344 0.0963547659469469 129 6787421 SGTC_975 1335-0046 28.5 µM 1.29990905855635 0.0840450622306428 no 345 0.0968160700140131 124 16486740 SGTC_2665 lovastatin 100 µM 1.29921809482777 0.0841605237117718 no 346 0.096934546684392 121 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_1495 4469-0029 237 µM 1.29681217328702 0.0845634873835032 no 347 0.0973479105658781 124 793680 SGTC_507 nimesulide 162 µM 1.2939053205534 0.0850522797485181 no 348 0.0978490632452587 126 4495 A COX2 inhibitor. SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.29002922639793 0.0857073420556856 no 349 0.0985202553770394 110 364106 SGTC_1334 1486-0610 236 µM 1.28961691861074 0.0857772439738729 no 350 0.0985918492730474 130 3742339 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.28239051797499 0.0870093328786926 no 351 0.0998528443873116 129 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2029 5175081 200 µM 1.28081061403308 0.0872804561546013 no 352 0.100130097500821 116 1380876 SGTC_2727 riluzole 51.77 µM 1.27641947335931 0.0880373207855396 no 353 0.100903638032314 130 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1162 k048-0130 20.1 µM 1.27253712883725 0.0887105549627704 no 354 0.10159117039214 129 6797406 SGTC_1722 st034304 3.6505 µM 1.26824573856706 0.0894591745294767 no 355 0.102355103914049 136 4036148 YLR033W RSC58 SGTC_776 4476-4378 112 µM 1.26715716923578 0.0896498170347075 no 356 0.102549548570837 126 2892008 SGTC_1509 1326-1131 80 µM 1.26694489716316 0.0896870276770905 no 357 0.102587496734747 112 768313 SGTC_2583 asiatic acid 100 µM 1.26459340493497 0.090100005486153 no 358 0.103008559214231 170 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2945 9067681 61.76 µM 1.26308848425175 0.0903650456536954 no 359 0.103278691025607 156 16456930 SGTC_2517 totarol 10 µM 1.26176104476639 0.0905993087869036 no 360 0.103517391741871 112 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_3124 9127567 49.47 µM 1.25774451625862 0.0913108808464361 no 361 0.104242083628528 118 17592030 SGTC_1028 k015-0029 4.8 µM 1.25630318973694 0.0915672352487858 no 362 0.104503032944725 141 4588309 SGTC_1824 st053723 68.6 µM 1.25423823395326 0.0919354372414318 no 363 0.1048777133395 116 675225 SGTC_188 3229-0966 278.469 µM 1.25421938361649 0.0919388034854899 no 364 0.104881138153948 170 5722370 SGTC_1258 0671-0043 57.1 µM 1.25396222473517 0.0919847353658625 no 365 0.10492786803003 152 4298767 SGTC_880 0833-0487 87.2 µM 1.25371022101828 0.0920297629506016 no 366 0.10497367575152 136 76075 SGTC_2840 9008771 71.43 µM 1.25359262927988 0.0920507796212127 no 367 0.104995055824104 84 2992978 SGTC_617 3770-0098 35 µM 1.25199937299479 0.092335885882059 no 368 0.105285046217382 123 5962639 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 1.25198821619294 0.0923378846446017 no 369 0.105287078920677 118 115019 SGTC_3224 9130643 49.47 µM 1.24998121150516 0.0926979645813186 no 370 0.105653205408551 120 17644395 SGTC_888 0916-0002 6.97 µM 1.24953250071595 0.0927786103617551 no 371 0.105735186934617 111 2802138 YIL048W NEO1 SGTC_2337 9009472 200 µM 1.24470753203174 0.0936490717830246 no 372 0.10661963815372 132 5742383 SGTC_1100 amiodarone 5.07 µM 1.24087630307582 0.0943445386428429 no 373 0.107325724004367 105 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_568 1193-0097 7.48 µM 1.23911784726594 0.0946650160099612 no 374 0.107650929242513 156 3646150 SGTC_2271 7849410 118.62 µM 1.23714877213816 0.0950248300958556 no 375 0.108015927923488 140 972430 SGTC_69 0096-0274 206.684 µM 1.233463860005 0.095700888257354 no 376 0.108701376086562 196 6741392 SGTC_570 0987-0065 62.6 µM 1.23191042439999 0.0959869496872186 no 377 0.10899127346711 125 3104428 SGTC_2820 7989630 71.43 µM 1.23120489704673 0.0961170782957746 no 378 0.109123120167061 91 2984098 SGTC_3257 9139206 32.98 µM 1.22842519937056 0.0966310324447765 no 379 0.109643696513619 133 4910041 SGTC_46 0329-0187a 2.197 µM 1.22793681752182 0.0967215402556713 no 380 0.109735343560668 135 46494817 SGTC_626 0214-0009 33 µM 1.22792111340575 0.0967244516037989 no 381 0.109738291420844 144 3437874 SGTC_1735 st034310 56.75 µM 1.2252479862622 0.0972209545155233 no 382 0.110240899685576 146 871153 SGTC_2944 9067346 25.62 µM 1.22287708417707 0.097662885291577 no 383 0.110688062527015 148 6473075 SGTC_691 1548-0686 185 µM 1.22099142356258 0.0980154183868774 no 384 0.11104463352632 163 46495133 SGTC_1856 st057054 55.7 µM 1.21946163012363 0.0983021048539735 no 385 0.11133451528876 150 1266018 SGTC_677 0929-0063 136 µM 1.21827159175543 0.0985255448531746 no 386 0.111560390891098 123 1539583 SGTC_724 3910-0327 137 µM 1.21471025576074 0.0991964374934313 no 387 0.112238309794603 150 2885483 SGTC_2892 9047358 58.44 µM 1.21381447096129 0.0993657120859216 no 388 0.112409289547275 129 6466771 SGTC_2724 maprotiline 69.64 µM 1.21231184333624 0.0996501345506695 no 389 0.112696516018847 136 4011 A tricyclic antidepressant. SGTC_664 1222-0054 14.9 µM 1.21226794359183 0.0996584529777458 no 390 0.112704915303752 148 6813991 SGTC_1660 st012960 28.1 µM 1.21219963190281 0.0996713981578774 no 391 0.112717986185425 127 24207266 SGTC_2258 7960471 200 µM 1.20669060100113 0.100719417440009 no 392 0.113775660055856 129 2974708 SGTC_3286 9117135 37.221 µM 1.20179942541909 0.101656613534462 no 393 0.114720624071937 136 3438150 SGTC_1802 st050112 57.9 µM 1.20058996789072 0.101889333259968 no 394 0.114955147234802 124 4662563 SGTC_2332 7982454 138.89 µM 1.19526252564668 0.102919037797757 no 395 0.115992238131295 158 2981748 SGTC_1706 st031321 9.9705 µM 1.19230984941789 0.10349298622425 no 396 0.116569886962021 147 6103185 SGTC_2190 6049624 200 µM 1.19038947825915 0.10386751729973 no 397 0.116946673297973 142 2265554 SGTC_360 0957-0399 1.01 µM 1.18518573646983 0.104887345011775 no 398 0.117972009101283 139 6752301 YPR165W RHO1 SGTC_2719 novobiocin 32.65 µM 1.18479972964454 0.104963282332242 no 399 0.118048319760658 142 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1905 st060207 84.5 µM 1.18088045359813 0.10573655757885 no 400 0.118825108650769 160 1948547 SGTC_417 st075190 100 µM 1.17838645941139 0.106230763267726 no 401 0.119321286692667 166 222757 SGTC_328 k915-0120 63.5 µM 1.17710184245728 0.106485970848182 no 402 0.119577429905602 117 6624543 SGTC_854 0422-0053 192 µM 1.17448715854936 0.107006782055445 no 403 0.120099976269547 156 3596728 SGTC_2291 7917025 104.35 µM 1.17225775196137 0.107452300136179 no 404 0.120546794027188 134 2964612 SGTC_1015 4130-4525 82 µM 1.17225764601624 0.107452321339663 no 405 0.120546815288492 158 1363237 SGTC_3164 9100705 49.47 µM 1.17224763398203 0.107454325126431 no 406 0.120548824537717 105 17174235 SGTC_1852 st056254 31.4 µM 1.16979252344127 0.107946498944864 no 407 0.121042236581547 144 442583 SGTC_675 1309-0189 238 µM 1.16851914697162 0.108202409998941 no 408 0.121298710274339 136 4246530 SGTC_2877 9040724 71.43 µM 1.16673876390814 0.108560946093364 no 409 0.121657941638862 133 6463895 SGTC_2927 9011802 47.9 µM 1.16443240878541 0.109026672717411 no 410 0.122124410074141 130 43912568 SGTC_3008 9078912 71.4286 µM 1.15738083121514 0.11045951401746 no 411 0.123558401062129 158 16648731 SGTC_1649 st011737 51.3 µM 1.15718426988372 0.110499646678487 no 412 0.123598541510691 138 1761035 SGTC_2980 9014342 25.29 µM 1.14931510949799 0.112114917125623 no 413 0.125213034979912 186 2996599 SGTC_1348 1493-0373 93.8 µM 1.14894536342042 0.112191226398883 no 414 0.125289255278406 160 3010129 SGTC_1715 st032160 10.2275 µM 1.14728838606583 0.112533654152481 no 415 0.125631226188411 136 5289825 SGTC_666 0272-0154 136 µM 1.1458292569411 0.112835812579492 no 416 0.125932903510407 167 6870312 SGTC_44 0929-0055 61.211 µM 1.14206031802066 0.113618968606344 no 417 0.126714474199146 163 1379590 SGTC_1898 st060199 18.6 µM 1.14037797221336 0.113969795015018 no 418 0.127064432968673 140 688866 SGTC_689 0833-0039 98 µM 1.1362683962808 0.114830025161879 no 419 0.127922126599227 163 5374726 SGTC_220 paclitaxel 373.376 µM 1.13458229536952 0.11518429842577 no 420 0.128275187347068 131 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_574 1315-0397 40 µM 1.13279502938912 0.11556067553165 no 421 0.12865016965991 191 6794277 SGTC_2208 7283366 200 µM 1.13108883522434 0.115920794308779 no 422 0.129008851503613 162 898663 SGTC_477 mead ethanolamide 10 µM 1.13105494755715 0.115927954888173 no 423 0.129015982498811 96 16061185 SGTC_1966 st070145 16.1 µM 1.12991908643154 0.116168147908625 no 424 0.129255160339174 170 3748532 SGTC_3061 glucosamine 200 µM 1.12755477893106 0.116669244546668 no 425 0.129753996868449 140 91431 and experimental redox chemotherapeutic SGTC_1392 3455-1037 33.9 µM 1.12115114249893 0.11803413701718 no 426 0.131111766191561 139 981132 SGTC_2117 5521686 200 µM 1.11997201156868 0.118286687266821 no 427 0.131362844607381 153 803312 SGTC_1391 3442-0225 151 µM 1.11823872620217 0.118658621365195 no 428 0.131732524334129 143 5227075 SGTC_1477 0139-0234 16 µM 1.11784663028631 0.118742873080568 no 429 0.131816251061202 159 620880 SGTC_1950 st077106 7.18 µM 1.11266583792864 0.119860066900634 no 430 0.132925986357369 136 13831864 SGTC_2132 5317594 122.667 µM 1.1098195958759 0.120476979203276 no 431 0.133538386675535 174 794577 SGTC_709 3807-1509 243 µM 1.10849747337383 0.120764303621257 no 432 0.133823514856353 180 1886677 YPL242C IQG1 SGTC_2558 carylophyllene oxide 100 µM 1.10473153696056 0.121585361528217 no 433 0.134637966936333 163 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2868 9035608 32.47 µM 1.10305154705751 0.121952899376125 no 434 0.135002390302827 142 6462614 SGTC_1630 st005209 31.3 µM 1.10223327213376 0.122132198855975 no 435 0.135180135261046 161 3367314 SGTC_2757 clomiphene 4.22 µM 1.10110282968186 0.12238020449529 no 436 0.13542595281653 196 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2177 5811945 192 µM 1.09996776869018 0.122629578793075 no 437 0.13567308273187 169 5343475 SGTC_2189 6047310 154.431 µM 1.09608383265393 0.123485580322198 no 438 0.136521044565563 147 711535 SGTC_2373 9071805 200 µM 1.0921565176022 0.124355389191833 no 439 0.137382155545851 156 10149009 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 1.09082508752045 0.124651240170279 no 440 0.137674927586481 141 521171 SGTC_2095 5432005 200 µM 1.08732849059562 0.125430544326052 no 441 0.138445830854476 163 783734 SGTC_403 arphamenine a 50 µM 1.08626056884829 0.125669233891997 no 442 0.138681863481843 175 5487158 An arginine aminopeptidase inhibitor. SGTC_210 3551-0445 56.827 µM 1.08312416298733 0.12637207857204 no 443 0.139376657599346 152 2865180 YOR207C RET1 SGTC_1237 0330-0133 46.1 µM 1.08302300390101 0.126394793057956 no 444 0.13939910627593 195 X1237 YHR072W ERG7 SGTC_445 e6 berbamine 66 µM 1.08238202231712 0.12653878660579 no 445 0.139541406606769 181 6610268 A calcium/calmodulin antagonist. SGTC_1716 st033144 30.6155 µM 1.0814707871102 0.126743688009684 no 446 0.139743874262588 171 674617 SGTC_802 4112-3352 742 µM 1.08105642342241 0.126836938681852 no 447 0.139836007893868 156 704594 SGTC_1658 st012944 20 µM 1.08045325782442 0.12697276372101 no 448 0.139970195348715 167 24207260 SGTC_2090 5301565 104.445 µM 1.07778938587366 0.12757384373338 no 449 0.140563878680521 170 2056344 SGTC_112 phenothiazine 287.218 µM 1.07632620149704 0.127904839278062 no 450 0.140890697240705 161 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.07280432689501 0.128703988522616 no 451 0.141679459516596 188 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1996 st072960 66.8 µM 1.07134706398278 0.129035667516182 no 452 0.142006702698221 169 1719405 SGTC_665 3914-0008 307 µM 1.06848718878774 0.129688308613715 no 453 0.14265040313153 168 1069549 SGTC_376 3970-0862 59.1 µM 1.06647338823399 0.1301492397677 no 454 0.143104851108816 195 3135186 SGTC_684 1140-0066 328 µM 1.0649826517252 0.130491178165291 no 455 0.143441890210075 166 6813534 SGTC_1209 2323-2347 50.3 µM 1.06431679163292 0.130644110695581 no 456 0.143592606852119 163 5412760 SGTC_1723 st034307 2.5525 µM 1.06294288748714 0.130960055940306 no 457 0.143903926118862 187 867466 SGTC_1539 benzyladenosine 56 µM 1.05988396121515 0.131665386778768 no 458 0.144598696586983 171 92208 A nucleotide analog. SGTC_943 3253-1379 105 µM 1.05890859174631 0.131890838828016 no 459 0.144820705510693 187 668464 SGTC_703 3875-0075 71.8 µM 1.05813316819925 0.13207026422308 no 460 0.144997367392878 189 2850814 SGTC_777 1315-0167 517 µM 1.05343732005662 0.133160433049483 no 461 0.146070303671511 162 4221767 SGTC_1623 st003709 20.3 µM 1.0527138682505 0.13332893561107 no 462 0.146236075331199 174 16192618 SGTC_2378 9074213 121.43 µM 1.05179237488362 0.133543777309429 no 463 0.14644740910153 175 657714 SGTC_719 2810-4230 27.3 µM 1.04934134792093 0.134116380670699 no 464 0.147010521084148 162 721079 SGTC_1749 st037932 54.2 µM 1.04644201147738 0.134795891867799 no 465 0.147678502392863 178 594497 SGTC_2499 avocadenofuran 51.48 µM 1.04569201631973 0.134972050491498 no 466 0.147851625011256 170 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1330 1469-0054 61.8 µM 1.04429549093044 0.135300486530081 no 467 0.148174349204508 166 7102664 SGTC_1071 trifluoperazine 6.31 µM 1.04379364589552 0.13541864457134 no 468 0.148290436019233 186 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2135 5326629 150.42 µM 1.04034486010551 0.136232564515516 no 469 0.149089854727188 158 5020077 SGTC_1378 2093-0007 380 nM 1.03984468823235 0.136350883391407 no 470 0.149206031703193 190 3618014 SGTC_291 SEC14.278 35.5 µM 1.03822661164292 0.136734131325935 no 471 0.149582283039204 168 1068044 SGTC_2385 9074692 200 µM 1.03525762127705 0.137439262478644 no 472 0.150274307716706 158 17046906 SGTC_982 1491-0518 27.5 µM 1.03335297825461 0.137892917610625 no 473 0.150719371511504 160 3091256 SGTC_2227 7312221 64.1025 µM 1.03245352243828 0.138107508140771 no 474 0.15092985492172 203 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_917 harmaline 728.087 nM 1.03121495846332 0.138403374995884 no 475 0.151220013740441 174 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1325 1431-0015 227 µM 1.03044964306145 0.138586408508968 no 476 0.151399489811659 155 1103340 SGTC_1917 st066507 28.5 µM 1.02942202905726 0.138832432868223 no 477 0.151640700903403 190 3156428 SGTC_368 fentichlor 4.58 µM 1.02878111029158 0.138986027795438 no 478 0.151791272570733 184 7329 A pesticide. SGTC_920 mycophenolic acid 780.421 nM 1.02831316449127 0.139098243131078 no 479 0.151901270257736 152 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1798 st045719 60.953 µM 1.02776335489721 0.139230168517851 no 480 0.152030578905054 182 3980186 SGTC_2798 7813637 45.45 µM 1.02718432349652 0.139369197627154 no 481 0.152166839191996 194 956368 SGTC_176 1486-1328 72.834 µM 1.02410831867907 0.140109349162015 no 482 0.152892057842334 170 22310231 SGTC_3331 9141060 1.957 µM 1.01995666733615 0.141112551441163 no 483 0.153874506158986 164 4906567 YPR165W RHO1 SGTC_678 1218-2179 85.9 µM 1.01965971929941 0.141184491955679 no 484 0.153944935803007 187 6820081 YOR116C RPO31 SGTC_500 h-89 112 µM 1.01860266062103 0.141440783481818 no 485 0.154195820328588 179 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3153 9100258 49.47 µM 1.01814478710161 0.141551896033321 no 486 0.154304576882488 175 25236848 SGTC_377 3970-0964 33.1 µM 1.0176027687074 0.141683504515869 no 487 0.154433385522452 174 16481235 SGTC_815 1582-0027 36.9 µM 1.01715968681827 0.141791151597849 no 488 0.154538735064159 187 3128206 SGTC_362 0310-0100 9.03 µM 1.01515842775719 0.142278048967077 no 489 0.155015156889452 168 790235 SGTC_2267 7931562 200 µM 1.01486921417624 0.142348506782359 no 490 0.155084087502326 162 934880 SGTC_2440 5628896 157.78 µM 1.0147468980832 0.142378312362461 no 491 0.155113246175137 175 5522048 SGTC_765 1319-0117 244 µM 1.01470194361154 0.142389267779992 no 492 0.155123963685415 167 3487746 YGL099W LSG1 SGTC_1409 3909-8004 61.9 µM 1.01248081874936 0.142931266733056 no 493 0.155654106679136 168 2119279 SGTC_750 4073-0104 132 µM 1.01244915801314 0.142939002651888 no 494 0.155661672161432 146 22330957 SGTC_1431 4049-0260 9.09 µM 1.01087261154256 0.143324570608515 no 495 0.15603870208303 199 3854841 SGTC_3209 9113616 49.47 µM 1.01010120778037 0.14351348457122 no 496 0.156223401825499 186 16649353 SGTC_2317 5986382 200 µM 1.00904973509368 0.143771256988055 no 497 0.156475391262672 193 877883 SGTC_1114 scopoletin 1.73284 µM 1.00893451130502 0.143799523506345 no 498 0.156503021345597 175 5280460 A coumarin with genotoxic properties. SGTC_444 curcumin 90.4 µM 1.00818704720793 0.14398298127265 no 499 0.156682337472085 180 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2260 7964312 200 µM 1.00725029150834 0.144213121609015 no 500 0.156907255391076 179 231951 SGTC_1319 1306-0155 43.7 µM 1.00680298103837 0.144323103418743 no 501 0.157014730906811 180 3122360 SGTC_2560 caryophyllene 100 µM 1.00553388370302 0.144635448544881 no 502 0.157319921103408 189 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1622 st003707 19.4 µM 1.00481017475815 0.144813768600265 no 503 0.15749413178222 159 10140899 SGTC_2948 9070189 9.45 µM 1.00023344011199 0.145944892114076 no 504 0.158598774851439 157 6473636 YDL196W YDL196W SGTC_2372 9071633 200 µM 0.999794014322585 0.146053806138098 no 505 0.158705101568483 170 21321366 SGTC_2254 7938975 95.19 µM 0.998834569683956 0.146291799331277 no 506 0.158937418275055 175 2969277 SGTC_1853 st056710 91.2 µM 0.998287837347848 0.146427534384159 no 507 0.159069901837424 194 269167 SGTC_3023 9089636 49.47 µM 0.996961842595195 0.146757084896579 no 508 0.15939151582152 180 17249241 SGTC_1177 0983-0204 23.6 µM 0.995637247470061 0.14708678401454 no 509 0.15971321510287 191 766818 SGTC_2185 6113692 200 µM 0.995578256452895 0.147101478750089 no 510 0.159727551897014 184 874150 SGTC_996 3970-0799 1.8 µM 0.995198664863863 0.14719605903036 no 511 0.15981982551595 213 6615648 YGL040C HEM2 SGTC_929 2805-0021 398 µM 0.994552070534537 0.147357260427581 no 512 0.159977084191306 205 3098024 SGTC_3238 9133470 49.47 µM 0.990777591899013 0.148300630097211 no 513 0.160897096700501 161 3534688 SGTC_3269 9137823 49.47 µM 0.989274682094803 0.148677380139378 no 514 0.161264383850213 145 17682936 SGTC_2677 mitomycin C 100 µM 0.988878524883555 0.148776795447912 no 515 0.161361289355699 202 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_132 0417-1715 25.805 µM 0.987934512256808 0.149013873634545 no 516 0.16159236087843 184 6769098 SGTC_2066 5222451 176 µM 0.987151773083759 0.149210641085432 no 517 0.161784120049049 203 2281147 SGTC_1355 1499-0035 1.68 µM 0.985152182995837 0.14971409182768 no 518 0.162274662137622 184 1548538 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.982406972182221 0.150407116593935 no 519 0.162949696419923 191 97141 SGTC_2618 avocadyne 43.43 µM 0.981477040998233 0.150642360339108 no 520 0.16317877543798 165 3015189 SGTC_3316 9136639 10.545 µM 0.981413026879751 0.150658562934671 no 521 0.163194552355411 195 4903665 SGTC_219 mitoxanthrone 164.414 µM 0.979807285910915 0.151065371246192 no 522 0.163590627485265 191 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_3094 9117742 49.47 µM 0.978974989638489 0.151276517665799 no 523 0.163796168672703 228 17149698 SGTC_1074 carmofur 3.8 µM 0.97874619318151 0.15133459574453 no 524 0.1638527008628 204 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_193 1273-0060 1.558 µM 0.973818529551319 0.152589041113714 no 525 0.165073325544469 189 2847393 YHR072W ERG7 SGTC_476 mead acid 10 µM 0.973491754161397 0.152672472212214 no 526 0.165154478227242 180 5312531 An omega 9 fatty acid. SGTC_2977 9011197 71.43 µM 0.972026234206636 0.153047015531472 no 527 0.16551874875802 203 2704722 SGTC_999 SEC7.066 22.7 µM 0.971374224824358 0.15321384534656 no 528 0.165680979515341 208 740511 YDR170C SEC7 SGTC_1279 0874-0590 65.2 µM 0.969437881612449 0.153710008125999 no 529 0.166163379703098 185 3523074 SGTC_3063 1327-0034 4 µM 0.968777494355534 0.15387946675974 no 530 0.166328108921642 197 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_631 k072-0230 41.5 µM 0.96631811652916 0.15451164251282 no 531 0.166942511730557 190 5773147 SGTC_3190 9110366 49.47 µM 0.965405306122547 0.154746713923753 no 532 0.167170922411526 167 17123768 SGTC_1251 0490-5699 265 µM 0.963389389325024 0.155266699429311 no 533 0.167676074571149 206 3883818 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.963130018316434 0.155333685216353 no 534 0.167741139543181 215 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_2178 5812956 200 µM 0.962709755639622 0.155442263758123 no 535 0.167846599787274 205 5403383 SGTC_119 0121-0043 24.815 µM 0.962272575384041 0.155555266233401 no 536 0.167956350597959 212 1092378 SGTC_8 0354-0001 70 µM 0.961792109737546 0.155679519618348 no 537 0.168077021145253 200 4993152 SGTC_1250 0485-0349 40.2 µM 0.961163070758273 0.155842294523485 no 538 0.168235090693078 186 6842794 YDL195W SEC31 SGTC_2060 5238662 140 µM 0.958712364322156 0.156477527722034 no 539 0.168851833960799 194 790130 SGTC_931 2812-0076 566 µM 0.95739551588848 0.156819563490335 no 540 0.169183830450403 187 3450959 SGTC_2123 5259487 200 µM 0.956454230487301 0.157064352505385 no 541 0.169421398770682 179 2173474 SGTC_3021 9087658 49.47 µM 0.954353714339856 0.157611514712474 no 542 0.169952313516067 172 25237042 SGTC_2970 9090938 41.86 µM 0.954016941882755 0.157699356722708 no 543 0.170037533345536 204 17217104 SGTC_1168 k815-0004 80.5 µM 0.95389049179917 0.157732347620815 no 544 0.170069538445179 209 642433 SGTC_1055 3448-0672 86 µM 0.953816623324714 0.157751622045021 no 545 0.170088236683308 187 748378 SGTC_1384 3089-0840 101 µM 0.953786389963251 0.157759511250731 no 546 0.170095889997706 162 1069836 SGTC_1745 st081495 74 µM 0.950826851038179 0.158533038637469 no 547 0.170846139821694 201 13842402 YBL026W LSM2 SGTC_840 0245-0196 390 µM 0.950314704900794 0.158667149053311 no 548 0.170976184630303 190 3827528 SGTC_1233 0325-0408 14.2 µM 0.950019865170267 0.158744389414599 no 549 0.17105107942969 188 12874 SGTC_3026 9090633 49.47 µM 0.947072429161684 0.159517895869734 no 550 0.171800936380153 196 25236842 SGTC_1937 st074714 47.2 µM 0.946302327999042 0.159720402173673 no 551 0.171997203159747 167 17250970 SGTC_2926 9010726 65.15 µM 0.944261997748055 0.160257741587897 no 552 0.172517890228799 191 2994293 SGTC_2457 5731572 11.68 µM 0.94379060275886 0.160382055554661 no 553 0.172638331830085 204 2865357 SGTC_506 n9-isopropylolomoucine 153 µM 0.94340896685957 0.160482744842009 no 554 0.172735879209242 173 6610355 SGTC_254 nsc-64875 3.808 µM 0.942677716993528 0.160675790232446 no 555 0.172922887192527 168 56993 SGTC_2154 5570129 200 µM 0.942481989778315 0.160727486710734 no 556 0.172972963851328 208 673366 SGTC_170 4197-0004 226 µM 0.94206446413357 0.160837802024306 no 557 0.173079818342759 222 218692 SGTC_701 4424-0219 185 µM 0.941860649408643 0.160891670284396 no 558 0.173131994524771 198 2911779 SGTC_1794 st048918 76.9 µM 0.939023789483409 0.161642675414939 no 559 0.173859265183285 157 672303 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.938835209656207 0.161692679232264 no 560 0.173907679160999 183 4174840 SGTC_505 gw-5074 63.9 µM 0.938765836556861 0.161711076736069 no 561 0.173925491428949 206 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2644 guaiazulene 100 µM 0.938261917578148 0.161844755236073 no 562 0.174054912708376 186 3515 A coloring agent. SGTC_1514 1189-1591 158 µM 0.937940379027219 0.161930089882005 no 563 0.174137525293412 216 767698 YMR146C TIF34 SGTC_707 0865-0008 204 µM 0.937658019278941 0.162005050846512 no 564 0.17421009225607 209 723043 SGTC_1335 1486-0900 202 µM 0.935014164704096 0.162708038741932 no 565 0.174890499828486 198 X1335 SGTC_1986 st071812 45 µM 0.932141440717346 0.163474127751383 no 566 0.175631716990642 200 11838594 SGTC_828 2074-0507 139 µM 0.932112188073141 0.163481940784182 no 567 0.175639274950076 199 X828 SGTC_2073 5212005 126 µM 0.93118377821547 0.163730033982508 no 568 0.175879253794701 209 691789 SGTC_1632 st005650 90 µM 0.929797835901374 0.164100845227874 no 569 0.176237883517539 196 2759605 SGTC_1512 0259-0544 12.2 µM 0.927478733018108 0.164722542582658 no 570 0.176839014352268 192 18476 SGTC_1031 k035-0009 16 µM 0.927408544714887 0.164741382187366 no 571 0.176857227929022 205 5180959 SGTC_1744 st037937 38.9 µM 0.926724589001975 0.164925039341908 no 572 0.177034773696866 200 1016152 SGTC_2396 5342950 42.78 µM 0.926310635615573 0.165036259315954 no 573 0.177142285151549 236 1886677 SGTC_2478 5763493 32.33 µM 0.926310492700761 0.165036297722336 no 574 0.177142322276325 205 1365576 YLR208W SEC13 SGTC_997 3996-0078 137 µM 0.925993482527467 0.165121504071814 no 575 0.177224683651562 193 735687 SGTC_222 nsc-310342 10.666 µM 0.925931075782771 0.165138281180751 no 576 0.177240900192277 192 432556 SGTC_2085 5307070 144.047 µM 0.925128718357707 0.165354081119588 no 577 0.17744947814462 218 2840351 SGTC_639 0833-0042 114 µM 0.923829040602228 0.165704026002484 no 578 0.177787666325792 227 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_83 0170-0301 39.027 µM 0.923083588160637 0.165904958821809 no 579 0.177981823308157 184 3089716 SGTC_2134 5324836 1.464 µM 0.922530038027235 0.166054267216859 no 580 0.178126084801829 208 699272 SGTC_1600 coumarin 106 71.1 µM 0.921277727925425 0.166392371559473 no 581 0.178452723048233 213 100336 A hepatotoxic, DNA x-linker. SGTC_2179 6298986 200 µM 0.919580361730496 0.16685134316865 no 582 0.178896046510489 201 738374 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.919084910131862 0.16698546822792 no 583 0.17902558070345 200 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_1081 sertraline 6 µM 0.916450504995382 0.167699802665136 no 584 0.179715328017848 214 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_227 fluconazole 33.516 µM 0.912582835445921 0.168752103880671 no 585 0.180730992577467 243 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_557 1315-0110 16.2 µM 0.910970788174105 0.169191953909734 no 586 0.181155382736636 198 6833801 SGTC_2539 epi(13)torulosol 80 µM 0.909208450162941 0.169673652479902 no 587 0.181620052287202 203 6708597 SGTC_1764 st044502 93.5 µM 0.906867676577673 0.17031481315102 no 588 0.182238388046763 190 8407 SGTC_1913 st060213 96.1 µM 0.905523582608196 0.170683674109307 no 589 0.182594036101012 228 688959 SGTC_2379 9035213 200 µM 0.903501409092225 0.17123958369635 no 590 0.183129920368111 216 646551 SGTC_3329 9141233 27.5565 µM 0.903427688536882 0.171259871837745 no 591 0.183149475134019 202 4909101 YNL103W MET4 SGTC_2783 7738165 71.43 µM 0.902142533580505 0.171613797642933 no 592 0.183490578498969 212 17201110 SGTC_2581 avocatin a 64 µM 0.901503484083611 0.171789962789487 no 593 0.183660341101482 193 6710728 A skin care supplement. SGTC_1111 tnp00062 510.699 nM 0.901076833962374 0.171907640612447 no 594 0.183773734568452 200 676306 SGTC_23 0213-0011 39.996 µM 0.900360991507461 0.172105198511268 no 595 0.18396408643537 210 627608 SGTC_1990 st072050 59.8 µM 0.8983485821171 0.172661358339378 no 596 0.184499869796897 213 17233948 SGTC_772 k072-0172 35.3 µM 0.898114730243011 0.172726061076964 no 597 0.184562193343562 173 5861980 SGTC_2198 6589944 200 µM 0.897868679948802 0.172794155588874 no 598 0.184627782007693 181 5290268 SGTC_2351 9026858 72.31 µM 0.895622593476771 0.173416551682049 no 599 0.185227182329738 220 1409300 SGTC_3321 9137793 26.8275 µM 0.891344660449026 0.174605919267455 no 600 0.186372148135591 214 4904192 SGTC_555 4296-0685 37 µM 0.890395523557378 0.174870502462227 no 601 0.186626772590849 228 2908540 YHR072W ERG7 SGTC_3336 9143619 71.43 µM 0.888329060473898 0.17544743314521 no 602 0.187181886067839 204 45595730 SGTC_3344 9148862 3.898 µM 0.887322992696112 0.175728750902057 no 603 0.187452515006626 216 4905352 SGTC_467 ro 31-8220 72.8 µM 0.885524238848415 0.176232432148552 no 604 0.18793697624361 216 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2280 7785178 200 µM 0.884141173351595 0.17662033437955 no 605 0.188310004689679 200 2954328 SGTC_2256 7954252 200 µM 0.88233939298578 0.17712648086957 no 606 0.188796649875006 208 2972920 SGTC_33 0986-0033 35.816 µM 0.881923569624472 0.177243421743893 no 607 0.188909070121242 188 2848082 SGTC_1887 st057648 70.8 µM 0.880159082620877 0.177740185882367 no 608 0.189386568042344 231 688672 SGTC_3270 9137563 49.47 µM 0.875896244166732 0.17894394255041 no 609 0.190543220761327 198 17015724 SGTC_3157 9099274 49.47 µM 0.875766332498202 0.178980707882586 no 610 0.190578538169455 208 17217662 SGTC_2437 5741531 144.16 µM 0.873053298497219 0.179749589283673 no 611 0.191317013707123 231 2262990 SGTC_977 1348-1378 135 µM 0.872477906028026 0.179912923444597 no 612 0.191473858059637 222 X977 SGTC_118 0083-0097 135.343 µM 0.872093722643702 0.180022031791535 no 613 0.191578625202069 251 5207356 SGTC_129 0088-0017 176.636 µM 0.87039064127439 0.180506208236955 no 614 0.19204347968997 206 182446 SGTC_2850 9015429 58.44 µM 0.869571047866559 0.180739504880995 no 615 0.192267432754871 236 6457570 SGTC_930 2810-3379 265 µM 0.868774779733083 0.180966342962948 no 616 0.19248516512824 219 1015764 SGTC_2240 6690706 185.951 µM 0.868317833532292 0.181096596727418 no 617 0.192610181009921 190 805876 SGTC_1906 st060206 94.7 µM 0.868258732317414 0.181113447978894 no 618 0.192626354131074 228 5133468 SGTC_1563 conessine 56.1 µM 0.867690192374561 0.181275603271214 no 619 0.192781978186963 205 441082 An anti-amoebic, histamine inhibitor. SGTC_1452 4194-0072 190 µM 0.867549851532754 0.181315644367114 no 620 0.192820404915131 215 1343545 SGTC_624 k048-0052 28 µM 0.866641964006946 0.181574810455018 no 621 0.193069106643975 195 6835531 SGTC_3308 9128332 17.569 µM 0.866601262171942 0.181586434651149 no 622 0.193080260866569 205 17332805 YDL196W YDL196W SGTC_1318 1280-3875 124 µM 0.866479664756406 0.181621164906213 no 623 0.19311358663734 241 373245 SGTC_830 4076-0286 57.8 µM 0.865927883496855 0.181778815082777 no 624 0.19326485548069 222 6866659 SGTC_2241 6772625 37.8075 µM 0.865856040339558 0.181799347786067 no 625 0.193284556342745 220 2285411 SGTC_337 1315-0038 354 µM 0.86319121153196 0.182561977938363 no 626 0.194016172454858 212 1626437 SGTC_1361 1608-0041 5.61 µM 0.86236333685961 0.18279930823494 no 627 0.194243804600129 242 X1361 SGTC_1287 0971-0001 34.6 µM 0.860025670933045 0.183470495790323 no 628 0.194887445952342 210 4665869 SGTC_2540 epiandrosterone 100 µM 0.858860084633986 0.183805730578308 no 629 0.195208856709462 239 441302 A steroid. SGTC_3059 1327-0034 3 µM 0.858239146473303 0.183984474545855 no 630 0.19538021201965 212 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1921 5740136 50 µM 0.856885808279494 0.184374422874025 no 631 0.195753998340946 193 1774243 SGTC_1588 farnesol 29.9 µM 0.856101744273716 0.184600576672178 no 632 0.195970751962208 216 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1247 0448-0043 5.84 µM 0.855856257373655 0.184671419849796 no 633 0.196038646462001 220 3089013 YGL099W LSG1 SGTC_586 0957-0265 8.15 µM 0.854036622324066 0.185197061216126 no 634 0.196542349034493 223 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_1011 4112-3381 17.4 µM 0.852829828791562 0.185546181861751 no 635 0.19687683986382 221 2877139 SGTC_1203 3992-3522 103 µM 0.852298554379936 0.185700006867282 no 636 0.197024204094758 238 5322312 SGTC_2359 9039622 200 µM 0.851252139659327 0.186003216711972 no 637 0.197314652479106 246 6463596 SGTC_2383 9036125 200 µM 0.848895758263453 0.186687126407544 no 638 0.197969649677091 218 79580 SGTC_1572 epiandrosterone 68.9 µM 0.848600607396843 0.186772899763085 no 639 0.19805178444134 198 441302 A steroid. SGTC_1808 st050063 61.5 µM 0.847331795566911 0.187141905034372 no 640 0.198405104484162 229 4011993 SGTC_1102 cgs 12066b 26.1 µM 0.846855445005344 0.187280557175208 no 641 0.198537849713251 206 6438352 A 5-HT1B full agonist. SGTC_169 k015-0017 16.025 µM 0.84388783453798 0.188145774115078 no 642 0.19936604345029 253 1840002 SGTC_2912 7964298 10.93 µM 0.843412468431868 0.188284597592359 no 643 0.199498900526029 230 2975850 SGTC_3025 9087895 49.47 µM 0.843333912612582 0.188307544713556 no 644 0.199520860726451 231 17173641 SGTC_2932 9016711 44.54 µM 0.842451025330229 0.188565565599088 no 645 0.199767771033091 216 7117328 SGTC_1396 3511-0007 98.6 µM 0.841554072768207 0.188827920123429 no 646 0.200018802999253 224 X1396 SGTC_161 4065-0411 162.148 µM 0.840913110855852 0.189015536284349 no 647 0.200198306465776 222 1906281 YLR208W SEC13 SGTC_1791 st048313 56.1 µM 0.840534141724324 0.18912651845359 no 648 0.200304483529365 197 1204976 SGTC_352 k048-0007 5.11 µM 0.840357443199906 0.189178278825203 no 649 0.200354001315946 251 6811911 SGTC_2601 securinine 100 µM 0.838919587681979 0.189599794650528 no 650 0.200757217591536 264 442872 A GABA receptor antagonist. SGTC_967 1306-0166 352 µM 0.838803533351088 0.189633841843729 no 651 0.200789783811671 249 4437607 SGTC_2233 sulbentine 40.3845 µM 0.838300334207437 0.189781510328614 no 652 0.200931024125699 235 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1797 st048695 56.8 µM 0.837181669126417 0.190110046291531 no 653 0.201245229810873 244 592262 YIL048W NEO1 SGTC_82 0054-0107 293.755 µM 0.829407832884566 0.192402751782027 no 654 0.203436835340035 212 3104697 SGTC_1179 1021-1431 9.29 µM 0.827860861324704 0.192861002560768 no 655 0.203874651222045 252 2840958 SGTC_2214 7179297 48.276 µM 0.827727701836646 0.192900478794463 no 656 0.203912363561538 229 769744 SGTC_462 ag-879 158 µM 0.827138349790997 0.193075256345539 no 657 0.204079324930457 252 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_152 4469-0003 551.229 µM 0.826090550485119 0.193386229138582 no 658 0.204376363820233 235 697280 SGTC_2202 7226349 200 µM 0.826026073499285 0.193405375019905 no 659 0.204394650696353 201 844334 SGTC_2404 5161160 200 µM 0.825493490946907 0.193563565011209 no 660 0.204545738291295 246 2831543 SGTC_2308 7584454 197.62 µM 0.822214471347978 0.194539251249781 no 661 0.20547742199714 224 893577 SGTC_2713 st079149 53.4 µM 0.822152443693444 0.194557736641102 no 662 0.205495070465026 232 3103253 SGTC_1936 st074407 74.3 µM 0.821469879003442 0.194761224172395 no 663 0.205689337168378 247 809813 SGTC_1513 0337-0559 19 µM 0.821228032070672 0.19483335510793 no 664 0.205758196064666 228 775073 SGTC_2112 5488546 200 µM 0.82122709073659 0.194833635892902 no 665 0.205758464108954 242 600757 SGTC_3079 9117512 49.47 µM 0.821065656367217 0.194881792835543 no 666 0.20580443550884 277 7185044 SGTC_715 0868-0130 184 µM 0.820925037646292 0.194923746230452 no 667 0.205844484236626 238 2876258 SGTC_2228 7354201 200 µM 0.820837985193344 0.194949720957776 no 668 0.205869279411761 257 753451 SGTC_2749 bexarotene 57.39 µM 0.819830418421201 0.195250512048578 no 669 0.206156393862216 245 82146 An retinoic acid receptor inhibitor. SGTC_2953 9074162 66.49 µM 0.819764660831824 0.19527015260216 no 670 0.206175140277624 220 16451992 SGTC_162 k030-0015 37.8 µM 0.819423685407304 0.195372014789878 no 671 0.206272363011014 246 1809920 YMR134W ERG29 SGTC_168 3970-0862 530.542 µM 0.818212389160292 0.195734135486507 no 672 0.206617961028773 256 3135186 SGTC_1377 2944-0135 198 µM 0.817577307132301 0.195924157879625 no 673 0.20679929484812 210 1894137 SGTC_3267 9137951 49.47 µM 0.815934364996852 0.196416260363777 no 674 0.207268838035379 244 16643986 SGTC_1118 chelidonine 707.474 nM 0.814687204544738 0.196790315971759 no 675 0.207625689708892 230 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_508 roscovitine 141 µM 0.813253027993878 0.197220995384093 no 676 0.208036500971566 255 160355 A CDKinase inhibitor. SGTC_452 diindolylmethane 8 µM 0.812498726329187 0.197447738819213 no 677 0.208252758560106 222 3071 Inhibits expression of several cancer promoting factors. SGTC_3320 9137005 35.139 µM 0.810797547203623 0.197959692383071 no 678 0.208740971649713 235 4908713 SGTC_3006 9075424 71.4286 µM 0.809117268943127 0.198466142269016 no 679 0.209223847998785 240 7465181 SGTC_3074 9116018 49.47 µM 0.805529478530957 0.19955014549961 no 680 0.21025710122218 280 17027303 SGTC_378 3970-0959 8.33 µM 0.804816210750671 0.199766073742763 no 681 0.210462872803038 242 6615653 SGTC_1915 st067105 30.6 µM 0.804145057762907 0.19996938083 no 682 0.210656602529541 242 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_928 2764-0428 58.7 µM 0.803036641664823 0.200305416860135 no 683 0.210976778149745 248 662578 SGTC_706 4262-0057 46.9 µM 0.801397061988497 0.200803106220288 no 684 0.21145090773988 234 883298 SGTC_2568 diosmetin 100 µM 0.800001276352723 0.201227376905807 no 685 0.211855028834983 265 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_81 0411-0046 9.971 µM 0.79869929479699 0.201623618493357 no 686 0.212232397899037 249 12925265 SGTC_2105 5350118 200 µM 0.79796248298329 0.201848064783347 no 687 0.212446130963292 227 2133313 SGTC_155 k072-0202 43.6 µM 0.797296377220584 0.202051101418022 no 688 0.212639461928715 253 5857737 SGTC_2814 7977482 42.97 µM 0.792808394173787 0.203422272950863 no 689 0.213944732561609 238 6456762 SGTC_2848 9016370 25.97 µM 0.79269258449038 0.203457728518279 no 690 0.213978475898787 224 7894410 SGTC_3084 9116877 49.47 µM 0.79152630697399 0.203814994197264 no 691 0.214318465524473 237 27241325 SGTC_1991 st073000 8.92 µM 0.791004660860725 0.203974910956428 no 692 0.214470635832868 246 4301969 YIL048W NEO1 SGTC_3143 9086658 49.47 µM 0.79015992821984 0.20423403219826 no 693 0.214717187469159 241 25236626 SGTC_2895 9054447 58.44 µM 0.788534377782034 0.204733220047507 no 694 0.215192099092065 254 2697450 SGTC_1907 st060210 83.7 µM 0.787217219041608 0.205138236122136 no 695 0.215577359515003 247 688793 SGTC_1235 benzylparaben 21.5 µM 0.786800955501213 0.205266332873141 no 696 0.215699197038506 252 7180 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.786662929656792 0.205308818045433 no 697 0.215739605081041 250 616764 SGTC_2897 9048598 12.99 µM 0.785372200815948 0.205706364780348 no 698 0.216117687406658 235 6467404 SGTC_512 prima-1 270 µM 0.784719652937186 0.205907524415124 no 699 0.216308978711086 219 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3125 9127534 49.47 µM 0.783213287999656 0.206372333910609 no 700 0.216750936518132 219 1639235 SGTC_1066 ketoconazole 628 nM 0.77965010115695 0.207474275706486 no 701 0.217798428626633 251 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_12 0849-0099 9.267 µM 0.779209641557189 0.207610732193355 no 702 0.217928115739864 241 6071388 SGTC_394 menadione 8.33 µM 0.778212422288117 0.207919871360467 no 703 0.21822189735613 251 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2339 9000433 200 µM 0.775989285474978 0.208610024035257 no 704 0.218877656113314 245 2988954 SGTC_1902 st060212 70.5 µM 0.774848766224722 0.208964611403729 no 705 0.21921451463752 234 688944 SGTC_358 0075-0058 9.45 µM 0.772498836754502 0.209696322651603 no 706 0.219909517797918 279 1069125 SGTC_1844 rapamycin 4 nM 0.770382532433044 0.210356576242319 no 707 0.220536505939915 251 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_837 0091-0265 12.5 µM 0.769295454153287 0.21069620149288 no 708 0.220858967620074 253 759367 SGTC_2120 5538279 151.968 µM 0.766984539775082 0.211419245731898 no 709 0.221545353796012 229 2058197 SGTC_532 1548-0774 215 µM 0.763691607785397 0.212452052589327 no 710 0.22252552154084 269 5932993 SGTC_972 1319-0219 195 µM 0.762494583752373 0.212828220728999 no 711 0.222882437265496 267 23903702 SGTC_2546 rhodinyl acetate 100 µM 0.762086686724505 0.212956492264628 no 712 0.223004134066956 246 6708682 SGTC_2470 5664817 21.68 µM 0.761558138272551 0.213122772183395 no 713 0.223161883711349 254 2859561 SGTC_1516 st013856 110 µM 0.75943163207443 0.21379253013443 no 714 0.223797198611395 239 5281404 A mutagen and neurotoxin. SGTC_1462 k081-0014 26.5 µM 0.757539903419502 0.214389372197245 no 715 0.22436323445029 225 3270634 SGTC_20 0481-0013 4.944 µM 0.756373800099067 0.214757761065974 no 716 0.224712555907424 253 182045 SGTC_2124 5246320 200 µM 0.756251676194091 0.214796363035356 no 717 0.224749157550474 259 579342 SGTC_2938 9059746 27.26 µM 0.756069905635421 0.214853826094402 no 718 0.22480364209749 246 6471769 SGTC_1810 st050138 53 µM 0.755336019218548 0.215085920127067 no 719 0.225023695937712 275 3444541 SGTC_1027 k015-0025 8.67 µM 0.753747088377539 0.215588923268174 no 720 0.225500550519909 241 3598955 SGTC_1276 0871-0068 94.2 µM 0.753407053874902 0.215696655527867 no 721 0.225602672640155 253 3414906 SGTC_1635 st007035 42.4 µM 0.752885360967653 0.215862002813992 no 722 0.225759402858295 246 3716403 SGTC_2697 mebhydrolin 72.4 µM 0.749474036613365 0.216945009617363 no 723 0.226785770877043 257 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2408 sulbentine 18.36 µM 0.749456423079361 0.216950609594074 no 724 0.226791077098466 241 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1657 st012939 43.4 µM 0.747944454513555 0.217431630175323 no 725 0.227246831020013 251 24207257 SGTC_1554 st069299 38.7 µM 0.747409238263849 0.217602052345032 no 726 0.227408285298704 235 24207999 SGTC_478 N-arachidonylglycine 10 µM 0.746447666412198 0.217908427134549 no 727 0.22769851703201 210 5283389 SGTC_2480 5767542 37.17 µM 0.744739682349633 0.218453235707904 no 728 0.228214552496335 258 2867358 SGTC_2692 st077426 47.7 µM 0.742460414547241 0.219181491448517 no 729 0.228904213642926 254 25238571 SGTC_63 0099-0242 26.702 µM 0.741633970260738 0.21944589554872 no 730 0.229154567899761 270 3898502 YLR359W ADE13 SGTC_284 0988-0104 32.6 µM 0.741497409852719 0.219489602918297 no 731 0.229195950838843 266 4666532 SGTC_2466 5983409 37.09 µM 0.741388095397876 0.219524593582398 no 732 0.229229080249408 244 2879657 SGTC_408 cantharidin 100 µM 0.740581748777787 0.219782797517818 no 733 0.22947353881459 237 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2990 9074105 71.4286 µM 0.739648378777098 0.220081893772244 no 734 0.229756689153572 273 6502001 SGTC_446 go6976 132 µM 0.739059771251536 0.220270631677173 no 735 0.229935351708268 258 3501 A protein kinase C inhibitor. SGTC_1214 0358-0031 63.7 µM 0.738389369117005 0.220485710150333 no 736 0.230138936420812 265 4301366 SGTC_1014 4130-3005 69.3 µM 0.737592611496399 0.220741482444134 no 737 0.230381023289128 257 743608 SGTC_440 fluspirilene 35.1 µM 0.736190892828705 0.221191869366655 no 738 0.23080726691932 273 3396 An atypical antipsychotic. SGTC_3306 9127676 59.7925 µM 0.735202918140189 0.221509631603988 no 739 0.23110796104619 253 41905287 SGTC_1903 st060211 78.3 µM 0.735178921113869 0.221517353010737 no 740 0.231115267357532 241 688960 SGTC_2622 2-methoxyxanthone 59.94 µM 0.733754007955722 0.221976116126395 no 741 0.231549337909603 245 71034 A hepatoprotective. SGTC_2676 harmalol 100 µM 0.733137880817411 0.222174651463193 no 742 0.231737169040341 255 5459187 A monoamine oxidase inhibitor SGTC_1427 4048-4900 550 nM 0.731265514777114 0.222778607593984 no 743 0.2323084950022 264 24132586 SGTC_2872 9044037 25.97 µM 0.731214572391933 0.222795052788994 no 744 0.232324050291954 251 6465195 SGTC_723 4182-0001 115 µM 0.727049009212396 0.224142116723236 no 745 0.233597966810096 255 744821 YLR208W SEC13 SGTC_1213 1315-0166 115 µM 0.725821864521043 0.224539832265698 no 746 0.233973990661445 241 768401 SGTC_3218 9131285 49.47 µM 0.724420680517184 0.224994442869851 no 747 0.23440375365257 268 17156417 SGTC_149 3970-0822 46.1 µM 0.721968893531542 0.22579117252355 no 748 0.235156801235465 260 3114250 YBL034C STU1 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.720576116285108 0.22624447747631 no 749 0.235585176443831 277 688751 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.718334818825459 0.226975027235364 no 750 0.236275433091207 253 6708514 SGTC_2823 7987624 58.44 µM 0.718073191996381 0.227060390987453 no 751 0.236356079327852 288 2239440 SGTC_2425 5628681 7.85 µM 0.717246226634594 0.227330332719063 no 752 0.236611090290181 278 5714958 SGTC_2301 7769476 200 µM 0.717115528882852 0.227373012204477 no 753 0.236651407349178 263 977820 SGTC_308 4092-1169 104 µM 0.715642704392302 0.227854276502636 no 754 0.237105998825665 276 2268590 YDL196W YDL196W SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.715544136145291 0.227886505392951 no 755 0.237136439316768 259 5379071 SGTC_1754 st042065 16.137 µM 0.715224651947853 0.227990984867893 no 756 0.23723511927431 266 1126236 YIL048W NEO1 SGTC_2149 5554786 194.827 µM 0.715094009191856 0.228033716139102 no 757 0.237275477756055 261 745063 YPR165W RHO1 SGTC_31 0508-1974 57.237 µM 0.714791534132486 0.22813266844587 no 758 0.237368933566336 238 6810525 SGTC_1314 1222-0010 41.1 µM 0.712617408920918 0.228844626248207 no 759 0.238041268073283 278 3526027 SGTC_3297 9117502 71.43 µM 0.712457952522055 0.228896892258496 no 760 0.238090620010342 245 7453720 SGTC_3284 9108171 64.8615 µM 0.711930478884765 0.229069833280657 no 761 0.238253913649615 256 8687505 SGTC_2394 5221648 200 µM 0.711451787843732 0.229226843538637 no 762 0.23840215841212 272 788586 SGTC_2213 7173844 200 µM 0.711037035322853 0.22936293079605 no 763 0.238530643026391 272 892728 SGTC_2091 4-phenylthiadiazole 200 µM 0.710560890961527 0.229519217570051 no 764 0.238678192711531 262 270010 SGTC_2584 androsterone 48.74 µM 0.71043361088869 0.229561005324151 no 765 0.23871764327187 238 2754130 A steroid. SGTC_1796 st049173 110.4 µM 0.710165918571978 0.229648906208584 no 766 0.23880062636057 285 94134 SGTC_2789 5281112 71.43 µM 0.70958753813732 0.229838890667508 no 767 0.238979974856687 257 765948 SGTC_2726 cimetidine 79.27 µM 0.708909577156097 0.230061696991447 no 768 0.239190295751613 275 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_656 4090-1979 187 µM 0.704484563447076 0.231518906509646 no 769 0.240565529974244 250 22330961 SGTC_165 k038-0023 64.381 µM 0.704384382741528 0.231551956661483 no 770 0.240596714534659 268 46368543 SGTC_1962 st076595 64.5 µM 0.703465721607663 0.231855150499575 no 771 0.240882780814115 269 279619 SGTC_812 4251-0442 148 µM 0.703070734490193 0.231985579529084 no 772 0.24100583459633 277 5723007 SGTC_3310 9130229 44.1445 µM 0.702877974870107 0.232049245676723 no 773 0.241065899092148 265 7761258 SGTC_2318 6029776 164 µM 0.702108699188539 0.232303424885436 no 774 0.241305688820841 279 818325 SGTC_740 k014-0057 261 µM 0.701767109874315 0.232416340310746 no 775 0.241412206634259 272 4012779 SGTC_2049 5262831 67.185 µM 0.701509304927783 0.232501580268181 no 776 0.24149261487407 271 763417 SGTC_3227 9130768 49.47 µM 0.700041570693863 0.232987199171717 no 777 0.241950671799268 277 17720899 SGTC_479 n-linoleoylglycine 10 µM 0.699509780023059 0.233163287939107 no 778 0.242116751599784 278 6433346 An anti-infammatory. SGTC_681 1642-0006 26.6 µM 0.699241932987638 0.233252006546785 no 779 0.242200424422426 299 4446530 SGTC_1374 2889-5571 141 µM 0.698851024385302 0.23338152028733 no 780 0.242322568614966 268 2853281 SGTC_1122 capsaicin 818.572 nM 0.698822094215923 0.233391106861209 no 781 0.242331609528033 266 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2673 kobusone 100 µM 0.698038427071934 0.233650873297729 no 782 0.242576581403062 296 6710676 An epoxy ketone and protein crosslinker. SGTC_3253 9135987 49.47 µM 0.696899427055927 0.234028709501305 no 783 0.242932868181662 264 4182430 SGTC_3213 9129884 49.47 µM 0.69685882724777 0.234042183767114 no 784 0.242945573295149 264 17190742 SGTC_2802 7925815 54.55 µM 0.696520546048628 0.234154469247398 no 785 0.243051447400653 268 1262923 SGTC_1953 st076800 12.1 µM 0.696474907924517 0.234169620166452 no 786 0.243065732976514 267 297591 SGTC_3325 9138760 55.175 µM 0.696124550777215 0.234285949613706 no 787 0.243175416357719 257 43844959 SGTC_2431 5490079 200 µM 0.694608933643829 0.234789549850186 no 788 0.243650206047696 300 5722345 SGTC_1130 3454-2858 15.9 µM 0.694515359342863 0.234820661762672 no 789 0.243679535991365 288 715628 YIL048W NEO1 SGTC_2689 tacrolimus 100 µM 0.693434567864696 0.23518017222466 no 790 0.244018437563785 263 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1910 st062352 60.4 µM 0.690753049105653 0.236073453862965 no 791 0.244860372724461 266 2245730 SGTC_3226 9131256 49.47 µM 0.690409965950826 0.236187878261136 no 792 0.244968205635235 246 17178073 SGTC_2929 9013348 24.6 µM 0.688238593315667 0.236912778063897 no 793 0.245651272108165 273 2995952 SGTC_2648 atorvastatin 78.68 µM 0.686146764051074 0.237612277915521 no 794 0.246310282095795 276 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1410 3909-8106 77.9 µM 0.685390674139666 0.237865390111936 no 795 0.246548713674082 286 1039210 SGTC_1929 genistein trimethyl ether 50.5 µM 0.68462656875934 0.238121335743969 no 796 0.246789798479229 264 136420 SGTC_904 1141-0088 396 µM 0.684256630034594 0.238245305051851 no 797 0.24690656410129 281 1378119 SGTC_1033 k072-0102 21.3 µM 0.683913818057142 0.23836021553367 no 798 0.247014793960719 277 5965931 SGTC_692 k241-0027 77.8 µM 0.682483827847992 0.238839875083061 no 799 0.24746653269084 264 3600480 SGTC_543 3844-1095 191 µM 0.681775488220709 0.239077667805575 no 800 0.24769046295858 288 4230703 SGTC_120 rhodamine 6G 52.259 µM 0.680544543645536 0.239491208973675 no 801 0.248079863720755 301 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_3169 9102970 49.47 µM 0.677736119640986 0.240436171550076 no 802 0.248969510269159 284 17027839 SGTC_609 0986-0026 86.3 µM 0.677221884429367 0.240609418193532 no 803 0.249132592300288 275 2848610 SGTC_1175 0741-0056 27.6 µM 0.676894343394867 0.240719802696591 no 804 0.24923649667092 278 765927 SGTC_1954 st077032 68.9 µM 0.676748832394726 0.240768850154097 no 805 0.249282663863176 301 698907 SGTC_693 4161-2696 114 µM 0.675898861930623 0.24105545870537 no 806 0.249552430176523 294 805759 SGTC_114 0364-0001 490.298 µM 0.675329717091352 0.241247476998947 no 807 0.249733153828098 280 4003655 SGTC_2259 7964009 200 µM 0.675039158949025 0.241345537653173 no 808 0.249825443123088 260 313134 SGTC_3277 9138724 49.47 µM 0.674299693170014 0.241595198095974 no 809 0.250060399541266 261 15943418 SGTC_2606 farnesol 9.78 µM 0.673294283016714 0.241934872220451 no 810 0.250380044572659 296 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3039 9090270 49.47 µM 0.669487128830331 0.243223449877854 no 811 0.251592394266655 258 17173750 SGTC_1729 st035615 45.989 µM 0.669252190634986 0.24330308892793 no 812 0.251667309411868 284 17385451 SGTC_1120 ficusin 1.78878 µM 0.669136677047386 0.243342250744309 no 813 0.251704147747642 295 6199 A DNA cross-linker. SGTC_1463 k081-0032 34.1 µM 0.666422015723743 0.244263564574165 no 814 0.252570697175678 266 977755 SGTC_2156 5649887 115 µM 0.666407082807587 0.244268637768635 no 815 0.252575468267659 292 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_418 lividomycin a 100 µM 0.665165397989791 0.244690676901394 no 816 0.25297235472276 280 72394 An antibiotic. SGTC_1727 st034309 9.9045 µM 0.664270041905566 0.244995245018809 no 817 0.253258745755165 302 870305 SGTC_919 tnp00227 403.569 nM 0.662930261483103 0.245451371069339 no 818 0.253687609758429 303 1269246 A methoxyflavone. YNL221C POP1 SGTC_1603 st002045 67.8 µM 0.662303931857626 0.245664760379622 no 819 0.253888228749023 288 5887985 SGTC_1961 st076550 68.7 µM 0.660135130881108 0.24640443586134 no 820 0.25458355799639 291 1579337 SGTC_1182 1222-0449 220 µM 0.659254318321999 0.246705179837999 no 821 0.25486623579487 286 658318 SGTC_583 1488-1091 88.9 µM 0.65906953135564 0.246768298295269 no 822 0.254925560027829 299 4303273 SGTC_688 0527-0193 473 µM 0.658659832334299 0.246908271733668 no 823 0.255057116068308 310 4007154 SGTC_225 nsc-122657 1.016 µM 0.657834313485888 0.247190438800225 no 824 0.255322301398835 285 275685 SGTC_2643 anethole 100 µM 0.65720944710922 0.247404136315611 no 825 0.2555231259758 310 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2869 9037858 32.47 µM 0.656923941559008 0.247501808966879 no 826 0.255614911501556 277 27187042 SGTC_1581 himbacine 57.9 µM 0.656384408476281 0.24768644174908 no 827 0.255788409872682 303 5281825 An alkaloid muscarinic receptor antagonist. SGTC_829 1635-0120 117 µM 0.6559387964107 0.247838989411191 no 828 0.255931752276896 290 285054 SGTC_1669 st015249 58.4 µM 0.654307200807687 0.248397965977265 no 829 0.256456953800999 291 722793 SGTC_2100 5377183 190 µM 0.654070659805534 0.248479059486021 no 830 0.256533141609063 274 2844202 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.654040759377817 0.248489311273764 no 831 0.256542773117148 279 688669 SGTC_1342 1486-1464 234 µM 0.652866008651191 0.248892269620063 no 832 0.256921332150699 294 3253938 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.652218871665515 0.249114396471521 no 833 0.257129993716095 295 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2349 9023730 187.07 µM 0.652114325456204 0.249150291377803 no 834 0.257163711654695 290 4126287 SGTC_2890 9046729 58.44 µM 0.652077039930333 0.249163093659576 no 835 0.257175737429925 294 903329 SGTC_400 oxethazaine 37.5 µM 0.650426910118323 0.249730029066168 no 836 0.257708249770294 283 4621 A local anesthetic. SGTC_374 0880-0231 82.3 µM 0.650222637228872 0.249800258758858 no 837 0.257774210337935 292 6833587 SGTC_785 1270-0111 65.3 µM 0.649195050043721 0.250153705611355 no 838 0.258106155388582 282 6741994 SGTC_421 streptovitacin 30 mM 0.649052791448807 0.250202657490068 no 839 0.258152127136239 300 91467 include heat shock SGTC_2917 7979103 53.79 µM 0.648000596358044 0.250564880659662 no 840 0.258492282282925 282 2980565 SGTC_443 clozapine 122 µM 0.647160514197045 0.250854282278807 no 841 0.258764031830108 299 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_795 0685-0265 78 µM 0.646735857073128 0.251000640579641 no 842 0.258901456039544 278 302754 SGTC_218 alverine citrate 93.75 µM 0.646699712247152 0.251013099999199 no 843 0.258913154688159 294 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_659 k018-0002 107 µM 0.646196298696011 0.251186664815162 no 844 0.259076118139429 293 6797879 YHR007C ERG11 SGTC_2367 9070478 135.38 µM 0.646038261284712 0.251241165379605 no 845 0.259127288449469 274 572802 SGTC_3281 9140613 49.47 µM 0.645356179256509 0.251476458964939 no 846 0.259348197025305 262 16013766 SGTC_1758 st042942 75.2445 µM 0.644178406179645 0.251883021976033 no 847 0.259729875938417 285 669317 SGTC_1761 st044296 37 µM 0.64263916578846 0.252414884748501 no 848 0.260229131592429 290 1826700 SGTC_2998 9066762 71.4286 µM 0.641587482706705 0.252778619059039 no 849 0.260570531238599 301 4945196 SGTC_3139 9095020 49.47 µM 0.640983872697178 0.252987507739323 no 850 0.260766580528646 254 25236292 SGTC_567 1080-0542 68.4 µM 0.639919901297553 0.253355932721757 no 851 0.261112337425784 263 5950415 SGTC_3100 9120536 49.47 µM 0.63807796325844 0.253994412981 no 852 0.261711465353334 294 16421196 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.636806402072984 0.254435672718783 no 853 0.262125477727667 304 6710655 SGTC_1035 k081-0041 55.2 µM 0.636494859560519 0.25454384607031 no 854 0.262226965188988 283 731709 SGTC_831 k061-1017 217 µM 0.636331564336416 0.254600554829882 no 855 0.262280167952002 302 1240153 SGTC_3170 9103054 49.47 µM 0.634972427857219 0.255072809003029 no 856 0.262723198855038 302 16432970 SGTC_1839 st053978 48 µM 0.633440443076874 0.25560567095503 no 857 0.263223030795424 303 3788398 SGTC_3309 9129340 25.759 µM 0.631915768578849 0.256136566885808 no 858 0.263720959467623 285 17158987 SGTC_363 0455-0021 3.06 µM 0.631724124217967 0.256203338648314 no 859 0.26378358071346 289 4597466 SGTC_832 4083-0019 164 µM 0.631500611245833 0.256281225375243 no 860 0.263856624846981 292 1990758 SGTC_52 0329-0193 875 nM 0.631489160947561 0.25628521575005 no 861 0.263860367086937 313 3739292 SGTC_296 1222-0039 74.9 µM 0.630702733267365 0.256559359559678 no 862 0.264117455789343 279 5984176 SGTC_1621 st003705 32.4 µM 0.630599670294278 0.256595297989406 no 863 0.264151157250291 299 24207032 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.630100222946504 0.256769494209094 no 864 0.264314506919924 303 2346 DNA damaging agent; causes G2/M arrest. SGTC_2781 5567276 71.43 µM 0.629301155421888 0.257048319313958 no 865 0.264575957538184 303 2853274 SGTC_2368 9071271 200 µM 0.629021441993941 0.257145959184963 no 866 0.264667509353753 307 27209959 SGTC_433 pimozide 108 µM 0.627422517353566 0.257704467533067 no 867 0.265191155706399 294 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3073 9114972 49.47 µM 0.627403628124368 0.257711069349487 no 868 0.265197345054466 280 41905075 SGTC_1519 esterone 74 µM 0.626939355194236 0.257873361090566 no 869 0.265349494314382 302 698 A steroid. SGTC_2899 9053889 58.44 µM 0.626639942119649 0.25797805236578 no 870 0.26544764000101 293 6470052 SGTC_1999 st074831 12.5 µM 0.624524722545147 0.258718276999639 no 871 0.266141519719986 311 17112523 SGTC_1801 st050089 28.441 µM 0.623837074990612 0.258959156994888 no 872 0.266367294282148 279 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2203 7227154 166.4 µM 0.622708725689598 0.259354664124681 no 873 0.266737973826815 287 896304 SGTC_2597 laccaic acid a 100 µM 0.621838158955062 0.259660026881222 no 874 0.267024146032532 309 5491415 A textile dye. SGTC_842 0271-0008 11.1 µM 0.620738391430269 0.260046049978948 no 875 0.267385882505233 280 1221709 SGTC_474 dl-dihydrosphingosine 5 µM 0.620320090642677 0.260192952980597 no 876 0.267523535220065 263 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1795 st049545 62.3 µM 0.618593419310488 0.260799794812772 no 877 0.268092119074329 260 5291882 SGTC_1596 piperlongumine 63 µM 0.61843021757016 0.260857190007157 no 878 0.268145892002011 276 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_781 4335-2806 94.4 µM 0.617490107177927 0.261187936836508 no 879 0.268455752245945 328 845254 SGTC_690 glyoxal 20.3 µM 0.615987851998581 0.261716902730465 no 880 0.268951268737064 299 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_78 0336-0123 156.75 µM 0.613494225646518 0.262596156671783 no 881 0.269774799849374 289 6765896 SGTC_2768 sulfasalazine 50.2 µM 0.613492281272455 0.262596842848425 no 882 0.269775442479847 309 5384001 An antioxidant and salicylic acid derivative. SGTC_86 0417-1630 471.922 µM 0.612754003510381 0.262857450043568 no 883 0.270019504307183 292 3634867 SGTC_1294 1000-1494 117 µM 0.611663104431598 0.263242772187654 no 884 0.270380338754034 292 712797 YDL207W GLE1 SGTC_2295 7971645 200 µM 0.611321681660974 0.263363427151855 no 885 0.270493319961164 298 2978226 YKL099C UTP11 SGTC_1826 st055655 41.6 µM 0.610753377367922 0.263564322088521 no 886 0.270681431490786 301 676168 SGTC_1701 st028638 40.4 µM 0.610742484535452 0.263568173456341 no 887 0.270685037710131 295 3490878 SGTC_1778 st046819 58.9 µM 0.609303066016645 0.264077359717385 no 888 0.271161787605039 314 671715 SGTC_2534 helenine 20.12 µM 0.608935887295157 0.264207327322915 no 889 0.271283467879542 296 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2151 5563267 85.4165 µM 0.60844834216781 0.264379950489643 no 890 0.271445078727189 324 5310824 SGTC_2646 retinol 96.75 µM 0.607950600018891 0.26455624328171 no 891 0.271610119133665 305 445354 A vitamin A analog and teratogen. SGTC_2695 st077686 51.995 µM 0.607718976467087 0.264638301251003 no 892 0.271686937467444 288 2876092 SGTC_2710 st078562 53.7235 µM 0.607364950487937 0.264763748105629 no 893 0.271804371663446 320 17250908 SGTC_235 0330-0087 5 mM 0.607010863621286 0.264889246771504 no 894 0.27192185131676 296 46494818 YHR062C RPP1 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.604522552215984 0.265772028540847 no 895 0.272748140043204 290 2333 A French combination drug. SGTC_257 daunorubicin 18.5 µM 0.603633383577863 0.266087841439048 no 896 0.273043706368256 298 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1385 3091-4834 14.1 µM 0.603044785253205 0.266297002948266 no 897 0.273239448163925 304 4072814 SGTC_3104 9120930 49.47 µM 0.60271087380667 0.266415697117905 no 898 0.273350523253233 315 17014836 SGTC_2444 5485484 36.41 µM 0.601935113530444 0.266691556814865 no 899 0.273608664913886 331 6790631 SGTC_2034 5197015 53.07 µM 0.601726807952676 0.266765654685404 no 900 0.273678001127902 314 780676 SGTC_1038 k292-0204 154 µM 0.601703337554758 0.266774004161081 no 901 0.273685813986514 302 4454212 SGTC_60 0986-0278 202 µM 0.600062566320181 0.267358027396856 no 902 0.274232269504212 329 3110598 SGTC_90 0870-0863 4.608 µM 0.599355269128421 0.267609984632049 no 903 0.274467999483429 331 1738164 SGTC_1925 st057770 10.1 µM 0.598445315303764 0.267934309264596 no 904 0.274771418432514 288 5989122 SGTC_1208 2323-2347 50.3 µM 0.597201676329007 0.26837788545203 no 905 0.275186370070003 304 5412760 SGTC_2561 acetosyringone 100 µM 0.597073529756498 0.268423613239635 no 906 0.275229144885841 327 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1393 3470-5649 58.2 µM 0.596904627780361 0.268483890158638 no 907 0.275285528692975 285 4108395 SGTC_1648 st011736 69.8 µM 0.596134155652655 0.268758938814237 no 908 0.275542804126897 300 2855514 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.594923092931949 0.269191558558133 no 909 0.275947440083739 326 688798 SGTC_2940 9060638 45.86 µM 0.594681794667831 0.269277797623515 no 910 0.276028096654224 303 4027022 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.59256767324417 0.270033968452999 no 911 0.276735259368185 295 688664 SGTC_2426 5582046 32.21 µM 0.592117408412112 0.270195154581313 no 912 0.276885985206134 302 2251934 SGTC_1740 st038286 13.222 µM 0.591923404682749 0.270264619005348 no 913 0.276950940209047 284 716786 SGTC_2621 lithochol-11-enic acid 100 µM 0.59164908317998 0.270362857020465 no 914 0.277042799390845 334 6708711 SGTC_1841 st054148 70 µM 0.59087141468501 0.270641446974028 no 915 0.277303290164773 323 675442 SGTC_322 k048-0136 19.3 µM 0.590114803187253 0.270912631050962 no 916 0.27755684251313 305 6823282 SGTC_1229 0139-0193 12.2 µM 0.590085075089753 0.270923288939282 no 917 0.277566807176183 318 3090752 SGTC_1710 st031758 61.5 µM 0.589930923291766 0.270978557608429 no 918 0.277618480649683 308 5394341 SGTC_2416 tofa 880 nM 0.589487666176033 0.271137511714751 no 919 0.277767091765585 287 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_947 3447-0010 211 µM 0.588425838830603 0.271518477039339 no 920 0.278123249255922 322 748350 SGTC_1951 sophoraflavanone G 9.2 µM 0.587564841274485 0.271827583714972 no 921 0.278412207979414 305 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1672 st016598 6.51 µM 0.586724097143776 0.272129588084412 no 922 0.27869451056754 329 4665860 YNL267W PIK1 SGTC_1224 0823-0416 294 µM 0.586321400416286 0.272274300153363 no 923 0.278829776232915 313 3598164 SGTC_1272 0839-0021 27 µM 0.585604975935197 0.272531847118857 no 924 0.279070501873883 327 5027250 SGTC_2513 baicalein 25.65 µM 0.585453380131791 0.272586359695254 no 925 0.279121452499968 309 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2806 7952793 58.44 µM 0.585436820989969 0.272592314551332 no 926 0.279127018222488 308 2972490 SGTC_1289 0976-0073 69.1 µM 0.58322377109177 0.273388733032596 no 927 0.279871335410929 325 3391136 SGTC_3103 9120822 49.47 µM 0.5821064190617 0.27379127590798 no 928 0.280247500845458 331 17141819 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.582030960484103 0.273818471557947 no 929 0.280272913400666 330 5024745 SGTC_67 0335-0847 266 µM 0.58150965105788 0.274006390574361 no 930 0.280448507817996 345 4552207 YOR254C SEC63 SGTC_1048 3161-0300 24.5 µM 0.581200458799846 0.274117876757532 no 931 0.280552679246376 302 2165101 SGTC_1070 indatraline 8.81 µM 0.579357097205553 0.274783006694547 no 932 0.28117412323249 322 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2336 9001819 198.65 µM 0.579284527384454 0.274809207929545 no 933 0.281198601956021 322 2989602 SGTC_3228 9131799 49.47 µM 0.577694208034408 0.275383699582293 no 934 0.281735295122453 319 17015818 SGTC_3272 9137413 49.47 µM 0.576586545874386 0.275784183559901 no 935 0.282109395008381 314 17614870 SGTC_1679 SEC14.276 6.7 µM 0.576211850962651 0.275919722212246 no 936 0.282235997927981 326 1005053 YMR079W SEC14 SGTC_871 0574-0004 149 µM 0.574749230506875 0.276449109874244 no 937 0.282730453557683 311 9551173 SGTC_309 k408-0051 1.48 µM 0.574518270241312 0.276532750222162 no 938 0.28280857036037 332 3640463 SGTC_965 1291-5240 308 µM 0.573852114797902 0.276774062373545 no 939 0.283033939612715 323 2834598 SGTC_1943 st076331 65.2 µM 0.572267207947175 0.277348602896999 no 940 0.283570480958077 316 24208415 SGTC_1651 st011928 86.1 µM 0.569879877927568 0.278215127082944 no 941 0.284379586756171 313 720198 SGTC_2255 7941087 197.44 µM 0.569344420223045 0.27840966214195 no 942 0.284561213616069 318 935561 SGTC_1339 1486-1321 22.7 µM 0.568487402494299 0.278721159805354 no 943 0.284852028635901 317 3469382 SGTC_40 0327-0103 19.753 µM 0.56832342009016 0.278780781329988 no 944 0.284907689553429 313 409036 SGTC_1054 3429-0080 167 µM 0.568046118569566 0.278881618095339 no 945 0.285001826437332 324 1162877 SGTC_539 4859-0462 2.54 µM 0.566789123313142 0.27933892901306 no 946 0.285428730571866 310 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1423 4048-0112 5.59 µM 0.566656872216291 0.279387064824622 no 947 0.285473663745366 313 X1423 SGTC_1344 1488-0097 29.1 µM 0.565911893844687 0.279658291993947 no 948 0.285726837906647 323 747966 SGTC_3022 9087993 49.47 µM 0.564974692088215 0.27999968408066 no 949 0.286045489067223 328 17173644 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.564867580746308 0.280038714116614 no 950 0.286081917966408 327 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3152 9099253 49.47 µM 0.564009339851007 0.280351541573073 no 951 0.286373887915232 304 25236131 SGTC_3088 9117578 49.47 µM 0.563069889890188 0.280694163486565 no 952 0.286693646903022 322 678341 SGTC_2388 9080168 200 µM 0.561631164848136 0.281219265693946 no 953 0.287183671193816 342 15943073 SGTC_3245 9134821 49.47 µM 0.560771001289676 0.281533432407075 no 954 0.287476828889066 336 17014901 SGTC_463 ikarugamyin 104 µM 0.560201450263301 0.281741548726769 no 955 0.287671018960738 339 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_1308 1187-1617 41.4 µM 0.559965989950795 0.28182760856824 no 956 0.287751317943533 323 2882570 SGTC_1446 4239-0190 62 µM 0.559955681429209 0.281831376582789 no 957 0.287754833698511 334 1340085 SGTC_942 3253-1115 227 µM 0.559668599384088 0.28193632178123 no 958 0.287852752119643 355 46497897 SGTC_2739 tacrine 100.86 µM 0.559598034944347 0.281962120073526 no 959 0.287876822765239 305 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2344 7990960 76.95 µM 0.55890789865892 0.282214493171895 no 960 0.288112289254198 317 140813 SGTC_2261 9010538 184.68 µM 0.55814348086532 0.282494156808616 no 961 0.288373205763115 346 6457250 SGTC_2904 7225135 42.03 µM 0.557658054803188 0.282671819968491 no 962 0.28853895264398 350 4446116 SGTC_1497 4476-2978 41.3 µM 0.557175251636197 0.28284857640803 no 963 0.288703848458332 323 1528379 SGTC_615 k087-0205 167 µM 0.556868089821375 0.282961057370892 no 964 0.288808779101022 318 9642773 SGTC_1489 4065-0444 182 µM 0.556119390880603 0.283235316728623 no 965 0.289064620000184 322 2877968 SGTC_960 1222-0186 7.7 µM 0.554977352572911 0.283653907466789 no 966 0.289455075640858 329 3126296 SGTC_111 0083-0039 52.457 µM 0.552569830931805 0.284537304715325 no 967 0.290279002560777 324 759313 SGTC_190 3970-0790 3.722 µM 0.552275113990447 0.284645536060947 no 968 0.290379939054607 317 2832352 SGTC_2645 abamectin 100 µM 0.552116600188564 0.284703756526062 no 969 0.290434234644241 301 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2238 6671620 73.2395 µM 0.552056333531955 0.28472589333136 no 970 0.290454878974658 291 729941 SGTC_1560 lithocholic acid 53.1 µM 0.551944384999562 0.284767015809369 no 971 0.290493228743553 317 9903 A bile acid which acts as a detergent. SGTC_3072 9116419 49.47 µM 0.551615089847261 0.28488799347175 no 972 0.290606047825662 306 17170162 SGTC_2774 tamoxifen 10.92 µM 0.550662721200089 0.28523801608739 no 973 0.290932452057486 320 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2961 9083290 32.55 µM 0.548935917490267 0.285873187742927 no 974 0.291524714082268 316 17741490 SGTC_714 4296-0578 26.1 µM 0.547620395342545 0.286357528227714 no 975 0.291976291074736 333 1589775 SGTC_2022 5136654 200 µM 0.54645613743483 0.286786501867875 no 976 0.292376215330554 342 1713771 SGTC_2654 protoveratrine a 100 µM 0.545728148336684 0.28705488589554 no 977 0.292626409979337 342 5702278 A heart drug and vasodilator. SGTC_201 4262-0159 12.803 µM 0.545220700690434 0.287242034354442 no 978 0.292800867945468 321 1341029 SGTC_499 genistein 192 µM 0.545012723795991 0.287318753637134 no 979 0.292872383311752 352 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_806 3966-4455 5.86 µM 0.544672031728774 0.28744445032662 no 980 0.292989551908536 320 714982 SGTC_2104 5389443 200 µM 0.544041842678733 0.287677024047705 no 981 0.293206339725118 333 2244536 SGTC_323 4013-0906 34.3 µM 0.541355243202801 0.288669520368574 no 982 0.294131375061184 299 2910086 SGTC_3024 9090631 49.47 µM 0.541016887877948 0.288794631451015 no 983 0.294247971284688 305 25236383 SGTC_1395 3486-0190 4.35 µM 0.54054148900352 0.288970459204742 no 984 0.2944118283643 340 6748079 SGTC_1664 st014217 9.02 µM 0.539870230289773 0.289218812060224 no 985 0.294643264715572 337 3982782 SGTC_2098 5376439 882.5 nM 0.538825984738376 0.289605362228075 no 986 0.295003466067971 337 2844116 SGTC_2800 7887935 81.82 µM 0.537711998372719 0.290017995656401 no 987 0.29538794725439 329 2961002 SGTC_3302 9125395 16.351 µM 0.537665207872395 0.290035333428498 no 988 0.295404101568597 317 17599668 SGTC_2152 5568786 200 µM 0.537508759496987 0.290093307404674 no 989 0.295458117966726 341 5399883 SGTC_1667 st014849 34.6 µM 0.537155885172495 0.290224089502167 no 990 0.295579970360248 304 5348460 SGTC_367 0335-0881 7.1 µM 0.536939165355066 0.29030442377591 no 991 0.295654818166254 345 23828853 SGTC_2685 mycophenolic acid 18.85 µM 0.536471596483034 0.290477778901598 no 992 0.29581633054448 318 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_595 3909-8003 73.7 µM 0.536375251483784 0.290513505647032 no 993 0.295849616046028 332 699517 SGTC_2205 7238770 200 µM 0.53628200798499 0.290548084249165 no 994 0.295881831671729 328 279867 SGTC_899 1083-0020 478 µM 0.533603774231351 0.291542106806458 no 995 0.296807848228311 350 767123 SGTC_810 3825-7150 143 µM 0.531727545266641 0.292239409716713 no 996 0.297457355596686 299 22330411 YGL099W LSG1 SGTC_2304 7443016 91.4 µM 0.529728817416394 0.292983091847628 no 997 0.298149982398267 330 939854 SGTC_1256 0570-0116 285 µM 0.528275758486388 0.293524293342778 no 998 0.298653977179505 333 410638 SGTC_2210 7115885 190.385 µM 0.527046415144454 0.293982531695085 no 999 0.29908067827073 341 2927039 SGTC_788 1182-0090 188 µM 0.527014996700667 0.293994247269413 no 1000 0.299091587137094 311 5715185 SGTC_2080 5212524 12.4 µM 0.525388979892692 0.2946008645704 no 1001 0.299656406375512 336 260183 SGTC_814 3342-0569 96 µM 0.524633600927088 0.294882869740783 no 1002 0.299918961901323 338 4346283 SGTC_2333 9017922 200 µM 0.524414067678003 0.294964851282863 no 1003 0.299995287053809 327 3163164 SGTC_79 0052-0007 94.094 µM 0.523168783341013 0.295430083459888 no 1004 0.30042840143683 316 2801472 SGTC_1605 st000082 49.1 µM 0.52313214154758 0.295443777766491 no 1005 0.300441149862022 347 1114022 SGTC_710 3448-4187 58 µM 0.522880041585269 0.295538004163199 no 1006 0.30052886719012 320 3946412 SGTC_974 1326-0144 138 µM 0.522604651610292 0.295640951364272 no 1007 0.300624701414365 341 5411856 SGTC_755 1995-0008 37.3 µM 0.521105926238565 0.296201498617121 no 1008 0.301146491410701 317 689533 SGTC_2232 chlorophetanol 41.5365 µM 0.519487510719206 0.296807358812247 no 1009 0.301710410016263 328 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2858 9025781 8.96 µM 0.519118378440536 0.29694562433201 no 1010 0.301839096456181 310 4894980 YPL153C RAD53 SGTC_1085 doxorubicin 7.67 µM 0.51808358612779 0.297333382487174 no 1011 0.302199975905195 355 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2709 st078560 56 µM 0.517731458338042 0.297465384811707 no 1012 0.302322823130294 356 17250903 SGTC_991 3996-0057 64.7 µM 0.516599282671177 0.297889985317549 no 1013 0.302717958275803 309 715343 SGTC_569 4130-2812 160 µM 0.515379977296724 0.298347570935161 no 1014 0.30314376067312 346 743552 SGTC_2498 4'-Methoxychalcone 54.63 µM 0.515371827590668 0.298350630464406 no 1015 0.303146607591577 299 641818 YHR062C RPP1 SGTC_180 1486-1293 102.781 µM 0.515276378504349 0.298386464632276 no 1016 0.303179951495965 328 4140536 SGTC_122 0236-0016 402.397 µM 0.515112002245325 0.298448180515569 no 1017 0.303237378060982 354 6808838 SGTC_1920 st075728 45.7 µM 0.514662493940542 0.298616980295094 no 1018 0.303394443315179 364 3400306 SGTC_3173 9105693 49.47 µM 0.514291485205493 0.298756334539217 no 1019 0.3035241069643 339 17096658 SGTC_3179 9107801 49.47 µM 0.513515160621464 0.299048024682375 no 1020 0.303795504277285 291 4818259 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.512725216352169 0.299344964838488 no 1021 0.30407177401016 317 16486 A toxic proline analog. SGTC_1597 7-benzyloxygramine 47.5 µM 0.51231506386519 0.299499193937174 no 1022 0.304215262098638 331 260807 SGTC_2011 4012611 177 µM 0.511257133737469 0.299897172183955 no 1023 0.304585508411762 327 2049887 SGTC_642 0335-0876 158 µM 0.510747231471826 0.30008907560587 no 1024 0.304764031674258 333 6812350 SGTC_3058 9093861 49.47 µM 0.508931379012661 0.300772928404077 no 1025 0.305400162102039 346 17217477 SGTC_3076 9116187 49.47 µM 0.505855887553563 0.301932764072791 no 1026 0.306478910779243 355 27241210 SGTC_2819 7996655 46.38 µM 0.50486563837327 0.302306636068158 no 1027 0.306826604957303 335 6456960 SGTC_2593 nobiletin 86.24 µM 0.503674029343099 0.302756807296542 no 1028 0.307245230651339 310 72344 An anti-infammatory. SGTC_541 4513-1321 94 µM 0.503359218570095 0.302875787996325 no 1029 0.307355869215103 333 747515 SGTC_1731 st035964 63 µM 0.502635668920248 0.303149328228509 no 1030 0.307610223318634 349 6739575 SGTC_682 0kpi-0099 17 µM 0.502389956872849 0.303242245569556 no 1031 0.307696621118644 329 1714895 YML126C ERG13 SGTC_329 k048-0121 21.3 µM 0.501755507433066 0.303482224922524 no 1032 0.307919756915116 328 6832902 SGTC_2655 perillic acid 100 µM 0.501395687568575 0.303618363822233 no 1033 0.308046337096532 330 5702197 An apoptosis inducer. SGTC_2464 5717415 7.67 µM 0.500937088014643 0.303791915814724 no 1034 0.308207699854232 316 5285744 SGTC_2363 9053361 176 µM 0.500295451003913 0.304034810588098 no 1035 0.308433528355946 359 6469797 YMR079W SEC14 SGTC_1774 st048371 48.465 µM 0.499016219733011 0.304519327873826 no 1036 0.308883978789513 335 4242727 SGTC_1548 st061468 90.8 µM 0.498749560979876 0.304620369892887 no 1037 0.30897791248425 350 390799 SGTC_2624 nerol 100 µM 0.498144354953748 0.304849749151282 no 1038 0.309191149801182 360 637566 A natural product oil. SGTC_3156 9099931 49.47 µM 0.498052976917945 0.304884389027617 no 1039 0.309223351379489 337 18111053 SGTC_1814 st052110 31.539 µM 0.497153611647602 0.30522541654492 no 1040 0.30954036545703 343 674163 SGTC_37 0566-0070 1.56 µM 0.497036948420374 0.305269666111381 no 1041 0.309581498056935 355 1626686 SGTC_2964 9083345 53.42 µM 0.494692995455552 0.306159313802395 no 1042 0.310408423339399 328 17741579 SGTC_195 4234-0266 16.654 µM 0.494604971397824 0.306192745672343 no 1043 0.310439496138781 346 2303354 SGTC_548 1436-0017 110 µM 0.494144721918363 0.306367576441874 no 1044 0.310601987835727 353 9677137 SGTC_2380 9035439 200 µM 0.493508153566089 0.306609456511987 no 1045 0.310826790052409 336 6462575 SGTC_3082 9117008 49.47 µM 0.493163423013469 0.306740480686591 no 1046 0.310948560107025 339 41448529 SGTC_71 0417-1750 47.813 µM 0.492833314408075 0.306865970543624 no 1047 0.311065184619065 301 6811472 SGTC_1485 3909-9022 254 µM 0.492586894125996 0.306959661275919 no 1048 0.311152255140661 346 714516 SGTC_359 0081-0058 15.9 µM 0.491005907073787 0.30756106345213 no 1049 0.311711134807856 410 3494159 SGTC_2451 5856223 45.7 µM 0.488269788280624 0.30860309631974 no 1050 0.312679378995147 324 2179896 SGTC_401 neomycin 50 µM 0.488105530314766 0.308665702072339 no 1051 0.312737547032945 325 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_848 0368-0089 85.6 µM 0.487200575076741 0.309010718999617 no 1052 0.313058098924895 356 762535 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.486817327058216 0.309156884293914 no 1053 0.313193895086609 366 91467 include heat shock SGTC_2353 9059630 146.67 µM 0.486749016444444 0.30918294015491 no 1054 0.313218102228094 347 4779114 SGTC_839 0122-0028 230 µM 0.485364730986521 0.309711157716416 no 1055 0.313708822931708 355 759448 SGTC_1565 sinapyl alcohol 95.1 µM 0.482890885203435 0.310656109986197 no 1056 0.314586606993625 355 5280507 A phenol propionate derived from cinnamic acid. SGTC_1995 st072814 61.1 µM 0.479101618960845 0.312105946184912 no 1057 0.315933169032648 338 5769371 SGTC_768 0384-0033 77.3 µM 0.479092262942363 0.312109529569636 no 1058 0.315936496842387 338 3965305 YMR134W ERG29 SGTC_1507 4075-3230 155 µM 0.478374231166461 0.31238459103067 no 1059 0.316191935556278 359 659771 SGTC_553 k007-0256 45.7 µM 0.477715981867869 0.312636843086718 no 1060 0.316426183846875 339 6287000 SGTC_1836 st055642 81 µM 0.476820546980581 0.312980129525803 no 1061 0.316744956591855 377 8571 SGTC_2315 7733312 200 µM 0.476235504162267 0.313204507354555 no 1062 0.316953304020119 326 726316 SGTC_2549 cedrol 20.94 µM 0.474888388163946 0.313721421290399 no 1063 0.317433264186964 333 6708665 A sedative which affects the nervous system. SGTC_679 0422-0091 41.4 µM 0.474229594224117 0.313974346302505 no 1064 0.317668095897959 358 627384 YHR062C RPP1 SGTC_3046 9092212 49.47 µM 0.474090953906784 0.314027584408375 no 1065 0.31771752455795 372 25236637 SGTC_1956 st077085 54 µM 0.473564587177805 0.314229745320351 no 1066 0.317905216732782 367 24208685 SGTC_3342 9147791 14.508 µM 0.472877556899205 0.314493695906678 no 1067 0.318150268804338 340 1838168 SGTC_2866 9034245 58.44 µM 0.47244006428112 0.3146618259061 no 1068 0.318306356518217 362 6462273 SGTC_1940 st075990 51.1 µM 0.471912172372729 0.314864747846414 no 1069 0.31849473965643 341 1084979 SGTC_1652 st011932 78 µM 0.471619246803809 0.314977372719088 no 1070 0.318599293121434 345 1551076 SGTC_3237 9133362 49.47 µM 0.471025805227939 0.315205593588325 no 1071 0.318811153562881 375 43845137 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.470059343427109 0.315577418469479 no 1072 0.319156310103151 354 5377381 SGTC_1771 st048882 4.1505 µM 0.468683325643004 0.31610713322189 no 1073 0.319648003636812 339 4580403 SGTC_2078 5212016 200 µM 0.468460010880719 0.316193136602507 no 1074 0.319727830815165 370 1899708 SGTC_2831 7999036 19.48 µM 0.467658148903322 0.316502033064822 no 1075 0.320014537098808 381 2988270 SGTC_2300 7976697 71.57 µM 0.467639581532659 0.3165091871788 no 1076 0.320021177148924 328 2236109 SGTC_1097 itavastatin 7.23 µM 0.46733488499304 0.316626598302031 no 1077 0.320130150747325 353 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_84 0443-0269 128.823 µM 0.467108071906281 0.31671400997743 no 1078 0.32021127969067 345 6150058 SGTC_895 0964-0006 13.7 µM 0.466881162614355 0.316801468971259 no 1079 0.320292451646943 362 6738897 SGTC_2075 5212009 200 µM 0.466504231941196 0.31694677422682 no 1080 0.320427309556862 376 780898 SGTC_415 dibenzyl ketone 100 µM 0.463602948924777 0.318066150892982 no 1081 0.321466120598053 385 7593 SGTC_139 0099-0334 718.624 µM 0.463441507624509 0.318128487342484 no 1082 0.321523966155055 350 97690 SGTC_3333 9141820 12.094 µM 0.463233737020077 0.318208720255542 no 1083 0.321598418197836 376 1939433 SGTC_637 1181-0519 7.26 µM 0.462163486828633 0.318622144256521 no 1084 0.321982042675151 361 6252091 YGR060W ERG25 SGTC_1269 0831-0796 3.05 µM 0.462099666512383 0.31864680437244 no 1085 0.322004924667611 355 927758 SGTC_3276 9139060 49.47 µM 0.460888129718949 0.319115093409423 no 1086 0.322439434259261 384 4870619 SGTC_1473 k844-0725 134 µM 0.460331369167959 0.319330392082742 no 1087 0.322639194138807 346 54682906 SGTC_2564 betulinic acid 100 µM 0.459668334445461 0.319586866346587 no 1088 0.322877150876114 350 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1670 st016595 4.04 µM 0.458890387548541 0.319887900839697 no 1089 0.323156440953931 378 597879 SGTC_1430 4049-0248 69.1 µM 0.458483470368212 0.320045408874082 no 1090 0.323302567688264 368 22774488 SGTC_978 1416-0512 87.4 µM 0.457045546638288 0.320602254915026 no 1091 0.323819154175885 358 6814003 SGTC_3203 9113543 49.47 µM 0.457027520314157 0.320609238301974 no 1092 0.323825632445316 350 17018012 SGTC_525 k781-2675 26.7 µM 0.456352447724305 0.320870806707852 no 1093 0.324068277284394 352 3651118 YDL195W SEC31 SGTC_2253 7938677 135.83 µM 0.455002526473159 0.321394123402368 no 1094 0.324553710615268 336 2301972 SGTC_514 4466-0038 2.65 nM 0.454919990117264 0.321426131344495 no 1095 0.324583400472112 320 5722064 SGTC_3038 9091290 49.47 µM 0.453649018085722 0.321919186897452 no 1096 0.32504073332721 391 25236843 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.45281402751082 0.322243280432367 no 1097 0.32534133092152 366 689007 SGTC_80 0159-0065 512.242 µM 0.451814629130364 0.322631364996577 no 1098 0.325701264959304 344 1548079 SGTC_629 3448-6466 76.7 µM 0.451448615274938 0.322773543215267 no 1099 0.325833125794853 367 573744 SGTC_3144 9087057 49.47 µM 0.451022783864967 0.32293899019371 no 1100 0.325986564036143 391 17249618 SGTC_1441 4106-0040 13 µM 0.450324834353089 0.32321023816829 no 1101 0.326238117306357 350 2904180 SGTC_636 0kpi-0074 126 µM 0.45024693338659 0.323240519086353 no 1102 0.326266199091137 347 616434 SGTC_1442 4112-3290 3 µM 0.450205194709237 0.323256743827368 no 1103 0.326281245478586 355 704353 SGTC_923 1900-2434 73.3 µM 0.449285884023611 0.32361418528988 no 1104 0.326612719701633 371 5910570 SGTC_2608 thymoquinone 42.66 µM 0.449221408380517 0.323639260477358 no 1105 0.326635972711339 352 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1746 st038117 42 µM 0.445537403944027 0.325073331609695 no 1106 0.327965717679528 347 2898218 SGTC_1556 plumbagin 1.48 µM 0.445298396795852 0.325166459711855 no 1107 0.328052063152098 360 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2004 4023728 41.89 µM 0.443370194497169 0.325918174468558 no 1108 0.328748995438304 383 360084 YDR527W RBA50 SGTC_927 2425-1185 123 µM 0.44326476219107 0.32595929797758 no 1109 0.328787120252895 377 730375 SGTC_315 k915-0449 187 µM 0.442547317514314 0.326239191009488 no 1110 0.329046598898474 370 20970215 YNL149C PGA2 SGTC_2012 4023501 200 µM 0.442512635066544 0.32625272397772 no 1111 0.329059144608893 385 3477460 SGTC_1450 4112-4260 37.6 µM 0.442460695910572 0.326272990880171 no 1112 0.329077932962675 367 1633175 SGTC_1193 1488-0126 41.5 µM 0.440879133560375 0.326890369339375 no 1113 0.329650250339905 341 1384710 SGTC_2879 9041815 71.43 µM 0.440842955752153 0.326904497257065 no 1114 0.329663346618783 347 4942971 SGTC_2211 7117706 200 µM 0.437876187793329 0.328063902681386 no 1115 0.330738019033998 364 822771 SGTC_375 3970-0961 9.27 µM 0.437263642466197 0.3283034907943 no 1116 0.330960079714919 340 2898222 SGTC_1475 4092-1048 11.7 µM 0.436380685550544 0.328648970706775 no 1117 0.331280274990317 369 2881759 SGTC_1323 1348-1351 11.2 µM 0.435829661267317 0.328864647590133 no 1118 0.33148016084455 372 6989654 SGTC_1570 verbenone 133 µM 0.435617595469052 0.328947667638209 no 1119 0.331557101200282 381 29025 A natural terpanoid with antifungal properties. SGTC_2829 7992743 58.44 µM 0.435549144513419 0.328974466791033 no 1120 0.331581937655523 336 16462845 SGTC_2541 muurolladie-3-one 83.07 µM 0.434827377651359 0.329257098368617 no 1121 0.331843865540822 380 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2975 9084847 53.72 µM 0.433849565702568 0.3296401484927 no 1122 0.332198842843257 332 27211724 SGTC_2026 5148700 152 µM 0.432006103877908 0.330362796153459 no 1123 0.332868488435781 345 79838 SGTC_1553 gossypol 38.6 µM 0.430561951289037 0.330929354721131 no 1124 0.333393455971876 373 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1448 4255-0083 152 µM 0.429943218446455 0.33117220974747 no 1125 0.333618473070846 390 5399660 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.429166902563495 0.331477017192402 no 1126 0.333900883708693 374 140250 A respiratory chain inhibitor. SGTC_2414 st077232 92.9 µM 0.42886487952401 0.331595631665183 no 1127 0.334010780036891 317 729801 SGTC_252 miconazole 1.30953 nM 0.427890114755288 0.331978569311866 no 1128 0.334365562199077 356 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1546 5-methoxyflavanone 78.7 µM 0.42464086239628 0.333256308625391 no 1129 0.335549250094584 344 147795 SGTC_2986 9022445 71.43 µM 0.424313691963663 0.333385073073425 no 1130 0.335668527535941 404 6459286 SGTC_896 0964-0007 44.5 µM 0.423286216985809 0.333789583948379 no 1131 0.336043224582501 362 6756758 SGTC_1720 st037298 9.481 µM 0.422367406709408 0.334151477863353 no 1132 0.336378432113938 393 597396 SGTC_503 tyrphostin 8 294 µM 0.42198561472613 0.334301900531113 no 1133 0.336517758721638 409 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_466 geldanamycin 89.2 µM 0.419657935956067 0.335219560353791 no 1134 0.33736767904824 366 5288382 HSP90 inhibitor. SGTC_450 aminopyrene 156 nM 0.418231818450779 0.335782276954181 no 1135 0.337888817105328 389 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1949 st076024 69.1 µM 0.417300466740732 0.336149968103195 no 1136 0.338229323581357 361 2921930 SGTC_1680 diphenhydramine 100 µM 0.417217995744882 0.336182534639206 no 1137 0.33825948174034 379 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2371 9071574 200 µM 0.415406621786107 0.336898128221469 no 1138 0.338922129995437 373 45596039 SGTC_862 0452-0056 10.2 µM 0.415130389354675 0.337007307393405 no 1139 0.339023226965158 354 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1282 0886-0010 32.4 µM 0.415019224863642 0.337051248351473 no 1140 0.339063914790831 394 2836211 YNL267W PIK1 SGTC_1545 lovastatin 49.4 µM 0.41466823961216 0.337189999944277 no 1141 0.339192392832203 348 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2755 lomerizine 42.69 µM 0.414211798785387 0.337370473395388 no 1142 0.339359500824313 356 3949 A calcium channel blocker. SGTC_3064 1327-0027 10 µM 0.414060308295875 0.337430379928817 no 1143 0.33941497013893 377 16000455 YPR107C YTH1 SGTC_1438 4092-1045 4 µM 0.413588331076394 0.33761704854824 no 1144 0.339587810240019 366 1351342 SGTC_128 0906-2981 13.371 µM 0.41269469142107 0.337970595542691 no 1145 0.339915157350829 369 6740226 SGTC_142 0335-0849 62.6745 µM 0.412236191807829 0.338152045382753 no 1146 0.340083156184581 343 3889043 YPR107C YTH1 SGTC_15 0266-0086 27.098 µM 0.410780075669642 0.33872854811358 no 1147 0.340616902100136 380 1712902 YIL048W NEO1 SGTC_2603 homopterocarpin 100 µM 0.409724996428445 0.339146509365854 no 1148 0.341003845724826 365 101795 A weak amylase inhibitor. SGTC_2148 5546263 113.568 µM 0.408590301251118 0.339596230849393 no 1149 0.341420174702287 352 792097 SGTC_1594 piperine 70.1 µM 0.408445463864846 0.339653651695622 no 1150 0.341473330632575 365 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_213 1246-0773 967 nM 0.408390049243725 0.339675621831255 no 1151 0.341493668863523 377 6251622 SGTC_1661 st013063 9.66 µM 0.407766458016701 0.339922893469166 no 1152 0.341722570549286 377 721395 SGTC_2289 7946404 165.07 µM 0.407704420077663 0.339947497043628 no 1153 0.341745346005867 367 1246120 YPR165W RHO1 SGTC_2409 alverine citrate 63.97 µM 0.407221190311314 0.340139164061911 no 1154 0.341922769720025 319 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2776 terbinafine 19.92 µM 0.407001420172838 0.340226346798628 no 1155 0.342003472565351 345 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2837 9008476 45.46 µM 0.406905560308451 0.340264377048905 no 1156 0.34203867598665 378 2992805 SGTC_1453 4237-0541 195 µM 0.40606345721116 0.340598532351232 no 1157 0.342347987549921 346 739892 SGTC_27 0485-0001 32.618 µM 0.405182561441512 0.340948214927469 no 1158 0.342671661193981 373 2054479 SGTC_1759 st043059 70 µM 0.402465969990705 0.342027459437316 no 1159 0.343670563938443 382 669426 SGTC_1371 2421-0008 32.7 µM 0.401803953301233 0.342290660831194 no 1160 0.343914156245254 384 2827552 SGTC_916 4466-0038 42 nM 0.400778067196865 0.342698679005149 no 1161 0.344291764087506 382 5722064 YGL116W CDC20 SGTC_878 0828-0289 13.7 µM 0.400439851260552 0.342833235416117 no 1162 0.344416288558407 371 745350 YLR208W SEC13 SGTC_1093 fluphenazine 7.97 µM 0.398114317625393 0.343758968823886 no 1163 0.345272960455266 394 6602611 An atypical antipsychotic. SGTC_1359 1582-0056 520 nM 0.398053848900566 0.343783052353767 no 1164 0.345295246312764 385 3661189 SGTC_2354 9060492 162 µM 0.397798712235974 0.343884675358766 no 1165 0.345389283295974 386 6471895 SGTC_1440 4100-1550 40 µM 0.39739251335305 0.344046490943627 no 1166 0.345539017720902 395 742806 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.397317241393986 0.344076479826367 no 1167 0.345566767383824 385 4213774 SGTC_1005 4092-0690 4.4 µM 0.396254876922489 0.344499837892113 no 1168 0.345958505746668 381 1529343 SGTC_259 usnic acid 108.925 µM 0.395131001549072 0.344947920516443 no 1169 0.346373105298025 406 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2712 st079126 47.7 µM 0.394206027632279 0.345316865505959 no 1170 0.346714467932879 380 3152970 SGTC_2328 6201408 200 µM 0.392490683092691 0.346001455146135 no 1171 0.347347847032207 374 2890418 SGTC_2393 9031399 185.94 µM 0.390587528880037 0.346761588535228 no 1172 0.348051072669589 391 1526623 YDL150W RPC53 SGTC_2356 9061756 188.97 µM 0.389210359667181 0.34731202490782 no 1173 0.348560270284532 375 20104043 SGTC_882 0843-0131 351 µM 0.388583926526536 0.347562508656569 no 1174 0.34879197945478 371 5425421 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.387459475124702 0.348012295487837 no 1175 0.34920804031775 372 688761 SGTC_1863 st057641 20.1 µM 0.387041108215871 0.348179699221944 no 1176 0.349362887527348 391 3921635 SGTC_971 1315-0384 26.7 µM 0.385151131592156 0.348936315541586 no 1177 0.350062723493013 396 6769120 SGTC_45 0kpi-0036 14.9 µM 0.385106591139422 0.348954153728273 no 1178 0.35007922245012 399 2795021 SGTC_850 0388-0143 75.9 µM 0.383257342487716 0.349695061049294 no 1179 0.350764482331295 372 67273 SGTC_2634 4'-methoxyflavone 100 µM 0.382255945077483 0.350096513366884 no 1180 0.351135764308651 373 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3330 9141424 71.43 µM 0.381963987448792 0.350213588447951 no 1181 0.351244038425999 362 27261020 SGTC_1643 st009866 20.2 µM 0.381639644748401 0.350343666642541 no 1182 0.351364336886258 375 3156273 YOR207C RET1 SGTC_334 1502-1024 68.5 µM 0.381638770814562 0.350344017158923 no 1183 0.351364661047774 383 3296216 SGTC_2053 5265679 138 µM 0.381609372121655 0.350355808427223 no 1184 0.351375565740427 373 764595 SGTC_2485 5633444 17.78 µM 0.380663218404665 0.350735370020904 no 1185 0.351726582526016 355 5724239 SGTC_482 fipronil 114 µM 0.378609962510662 0.351559571944587 no 1186 0.352488761497813 377 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_2231 micatex 6.853 µM 0.378422197918808 0.351634977846092 no 1187 0.352558490285919 395 20737 An antifungal of unknown mechanism. SGTC_1871 st057448 67.3 µM 0.37835713005266 0.351661110339098 no 1188 0.352582655228218 410 691747 SGTC_56 0957-0365 83.25 µM 0.377967654500689 0.351817545782185 no 1189 0.352727311322177 369 6752360 SGTC_5 0352-0601 109.883 µM 0.377504687154875 0.352003532329941 no 1190 0.352899290889645 373 762456 SGTC_2748 diazoxide 86.69 µM 0.376771418364452 0.352298178751029 no 1191 0.353171741465843 383 3019 A potassium channel activatior. SGTC_438 sphingosine 6.67 µM 0.376253409145823 0.352506381751943 no 1192 0.353364256393506 367 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2369 9071472 200 µM 0.375912897730814 0.352643267292727 no 1193 0.35349082580217 369 17296037 SGTC_1696 st025591 34.7925 µM 0.374665728463932 0.35314479198359 no 1194 0.353954541689361 368 2787147 SGTC_2325 6158266 200 µM 0.374156103153261 0.353349801313101 no 1195 0.354144090290362 361 3623240 SGTC_1685 st024049 53.0905 µM 0.374020214260154 0.353404473155665 no 1196 0.354194638527957 403 1941139 SGTC_316 k060-0003 58.6 µM 0.373700086760918 0.353533281216633 no 1197 0.354313730385636 392 6152314 SGTC_1624 st003710 6.25 µM 0.372845534270944 0.353877205241091 no 1198 0.354631705484243 417 24207033 SGTC_3335 9143315 29.6265 µM 0.371976155952868 0.354227218482916 no 1199 0.354955301185245 364 4899691 SGTC_124 0136-0217 7.121 µM 0.370976137885946 0.35462997984661 no 1200 0.355327652391883 374 3976905 SGTC_1550 gossypolone 36.6 µM 0.369850190594312 0.35508365428555 no 1201 0.355747057988379 371 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2971 9092186 9.93 µM 0.368164858498131 0.355763103785386 no 1202 0.356375155860131 328 25236400 SGTC_1032 k061-1018 98.7 µM 0.367642758545442 0.355973683936086 no 1203 0.356569813807183 382 4005393 SGTC_2799 7812892 81.82 µM 0.367432466942026 0.356058513902243 no 1204 0.356648228762991 387 20205235 SGTC_1612 st002233 45.4 µM 0.367410580078064 0.356067343299187 no 1205 0.356656390433086 384 1035021 SGTC_1500 4488-1866 171 µM 0.366825672718221 0.356303329815566 no 1206 0.356874528254325 430 2900003 SGTC_1540 guanosine 70.6 µM 0.366119476000612 0.356588325032716 no 1207 0.357137962609493 410 6802 Guanosine is a purine nucleoside SGTC_607 4491-0986 66.8 µM 0.365992868313867 0.35663942774451 no 1208 0.357185198600827 374 698981 YDR232W HEM1 SGTC_2194 5927483 104.545 µM 0.365200735388734 0.356959215064945 no 1209 0.357480784695186 330 760979 SGTC_834 0312-0008 75.7 µM 0.363770690101064 0.357536784672726 no 1210 0.358014625602376 389 6385573 YIL048W NEO1 SGTC_3356 9151811 4.48 µM 0.363635496861379 0.357591403703301 no 1211 0.358065108098059 390 1859254 YPR165W RHO1 SGTC_1241 0364-0022 50.8 µM 0.363406434323609 0.357683953255098 no 1212 0.358150647984535 399 4563895 SGTC_2863 9028737 58.44 µM 0.362684709493112 0.357975610893457 no 1213 0.358420211582993 417 6460917 SGTC_1277 0873-0036 22 µM 0.362125127345394 0.358201801811853 no 1214 0.358629263605693 370 5965735 SGTC_2707 st078556 66.6 µM 0.360574062421712 0.358829023891984 no 1215 0.35920894094449 381 17250899 SGTC_1611 st001856 99.4 µM 0.360187329070029 0.358985471119248 no 1216 0.359353524818228 426 647478 SGTC_2570 licareol 100 µM 0.360081083418692 0.359028455360859 no 1217 0.35939324927436 380 443158 SGTC_3264 9137442 49.47 µM 0.360000839527584 0.359060921146165 no 1218 0.359423252873789 369 17015726 SGTC_237 nikkomycin 200 µM 0.358618876074082 0.359620207723474 no 1219 0.359940111904713 400 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2268 7933382 153.85 µM 0.358426366772898 0.359698140965517 no 1220 0.360012131389239 355 935025 YOR257W CDC31 SGTC_2589 lobaric acid 100 µM 0.358330870193874 0.35973680286283 no 1221 0.360047859374211 368 73157 A novel microtubule depolymerizer. SGTC_2036 5160441 105 µM 0.357023566900307 0.360266210241824 no 1222 0.360537081508311 396 134534 YIL048W NEO1 SGTC_2015 5119600 184 µM 0.356089241008003 0.360644740484043 no 1223 0.360886867144533 414 2828786 SGTC_522 1273-0010 11.6 µM 0.355339202967714 0.360948707702334 no 1224 0.361167744767239 416 5705015 SGTC_1977 st070720 65.3 µM 0.355106827333559 0.36104290019216 no 1225 0.361254781038658 373 682188 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.355041952083231 0.361069198608104 no 1226 0.361279081340109 413 551469 SGTC_1848 st056003 16.4 µM 0.354510607885859 0.361284613784647 no 1227 0.361478127820909 388 146492 SGTC_2722 naftopidil 47.16 µM 0.354153493168188 0.361429418351108 no 1228 0.36161192739029 407 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1458 k015-0034 6.33 µM 0.352589896591277 0.362063666394398 no 1229 0.362197956547668 396 3598957 SGTC_546 peri-Naphthalide 147 µM 0.351730000678683 0.362412631099022 no 1230 0.362520379588652 370 223824 A penicillin ester. SGTC_1876 myriocin 605 nM 0.351421758268993 0.362537750517214 no 1231 0.362635980655118 418 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1222 0366-0074 1.18 µM 0.351314952698044 0.362581107649257 no 1232 0.362676039187472 417 286520 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.35130607441535 0.362584711818457 no 1233 0.362679369146754 427 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_2052 5265182 7.135 µM 0.351152420532722 0.362647090065948 no 1234 0.362737001438508 417 1239884 SGTC_70 0141-0289 43.283 µM 0.350572953402984 0.362882366788712 no 1235 0.362954375157892 373 352408 SGTC_655 k060-0012 42 µM 0.350253072275308 0.363012267922805 no 1236 0.363074390102574 416 5994525 SGTC_2348 9022543 33.42 µM 0.349745998413422 0.363218218801328 no 1237 0.363264664703575 422 3162678 YDL140C RPO21 SGTC_1993 st073995 70.8 µM 0.349583202073593 0.363284347833632 no 1238 0.363325759626622 388 3098394 SGTC_2031 5180455 200 µM 0.347601887968293 0.364089497797159 no 1239 0.36406959410514 396 29949 SGTC_1047 2043-3044 82 µM 0.34723151488761 0.364240073633394 no 1240 0.364208698278817 425 669592 SGTC_1362 1611-0397 101 µM 0.346337361300398 0.364603679699498 no 1241 0.364544596859915 375 27816 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.346109046063998 0.364696543250718 no 1242 0.364630382660745 386 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_1408 3909-7976 48.8 µM 0.345997330248633 0.364741984755468 no 1243 0.364672360563114 392 24152374 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.345106017858445 0.365104602834591 no 1244 0.365007334735071 415 804 An inhibitor of viral and cellular DNA polymerases. SGTC_3348 9149464 3.537 µM 0.34487586799912 0.365198255724984 no 1245 0.365093846701841 367 1951442 SGTC_1073 triclabendazole 3.09 µM 0.34461888185594 0.365302838373036 no 1246 0.365190454383078 377 50248 An antihelmetic and likely tubulin inhibitor. SGTC_51 1013-0126 23.419 µM 0.342599749934528 0.366124888883515 no 1247 0.365949795109933 418 1627850 SGTC_2943 9068529 45.32 µM 0.341968687570777 0.366381940012565 no 1248 0.366187228447418 416 3270634 SGTC_339 3091-4833 71.4 µM 0.341894884700267 0.366412006112248 no 1249 0.366214999672623 395 3240077 SGTC_1782 st039423 80.636 µM 0.341832442609407 0.366437444653791 no 1250 0.366238496506076 398 2068169 SGTC_355 1311-2252 105 µM 0.340316173134588 0.367055343840945 no 1251 0.366809219429901 391 5338538 SGTC_1000 4048-0884 8.67 µM 0.339841039003574 0.367249038042651 no 1252 0.366988120303662 407 13040088 SGTC_2125 5246583 200 µM 0.339832075168563 0.367252692583787 no 1253 0.366991495708179 427 835267 SGTC_902 1120-0002 2.07 µM 0.339579535940248 0.367355657362363 no 1254 0.36708659562012 380 3280475 SGTC_2350 9023895 38.85 µM 0.339473732166974 0.367398798296369 no 1255 0.367126441080528 398 2997209 SGTC_1200 1643-0193 18.4 µM 0.339422167807068 0.367419824000511 no 1256 0.367145860619946 416 5403974 SGTC_249 wiskostatin 11.211 µM 0.339421804918137 0.367419971972249 no 1257 0.367145997287948 407 2775510 A n-wasp and actin depolymerizer. SGTC_3193 9111931 49.47 µM 0.337862542312812 0.368055959028943 no 1258 0.367733388122855 391 17087244 SGTC_2072 5231554 129 µM 0.33624036491832 0.368717991596163 no 1259 0.368344808125381 416 789545 SGTC_2377 9073351 62.6 µM 0.335799267753301 0.368898076813113 no 1260 0.368511121196232 412 7337946 YHR072W ERG7 SGTC_564 3555-0129 330 µM 0.335460651399813 0.36903634207682 no 1261 0.368638811201613 407 563260 SGTC_3326 9140064 16.379 µM 0.334540828788251 0.369412013443499 no 1262 0.368985743454934 392 1868434 SGTC_610 4215-0184 155 µM 0.33219648272803 0.37037004796116 no 1263 0.369870449740616 413 5605015 SGTC_3037 9091026 49.47 µM 0.331134600655717 0.370804259132954 no 1264 0.370271408493679 394 25236398 YIL048W NEO1 SGTC_26 0302-0163 425.158 µM 0.330578519332437 0.371031710460223 no 1265 0.3704814369383 421 3100915 SGTC_1578 josamycin 24.2 µM 0.330102792635419 0.371226330482507 no 1266 0.370661146590878 374 5282165 A P450 substrate. SGTC_1772 st048439 82.2 µM 0.329802135986593 0.37134934625115 no 1267 0.370774736657546 379 2927068 YDL195W SEC31 SGTC_2184 6075246 200 µM 0.329219022782977 0.371587968547497 no 1268 0.370995072774549 397 2267320 SGTC_319 1348-1596 45.5 µM 0.328835376616255 0.371744991622715 no 1269 0.371140061023762 412 5380505 SGTC_3299 9121982 43.1275 µM 0.328752574728707 0.371778884523593 no 1270 0.37117135606271 385 17594604 YPL160W CDC60 SGTC_1127 asiatic acid 681.4 nM 0.3281805966569 0.372013036704352 no 1271 0.371387558885244 396 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1492 4158-0558 28.5 µM 0.328157268024821 0.372022587813718 no 1272 0.371396377770674 398 3967268 SGTC_1145 3546-0597 10.2 µM 0.326895402897993 0.372539332455271 no 1273 0.37187349910213 390 875334 SGTC_695 3505-6186 243 µM 0.325675706433079 0.373039026835624 no 1274 0.372334863225799 405 1819379 SGTC_1025 k007-0731 70 µM 0.325437764280722 0.373136533690596 no 1275 0.372424888950322 380 6256118 SGTC_725 1497-0963 19 µM 0.324873963003451 0.373367607524986 no 1276 0.372638231722494 422 3549977 SGTC_3271 9137798 49.47 µM 0.323479392852946 0.373939367307114 no 1277 0.373166105736794 392 6498326 SGTC_2136 5328288 199.296 µM 0.321556386562024 0.374728235514497 no 1278 0.373894394375345 393 262395 SGTC_1283 0922-0125 16.4 µM 0.321527110047672 0.37474024957929 no 1279 0.373905485581493 403 3360884 SGTC_1883 5-benzylidenerhodanine 20 µM 0.319343280993378 0.375636759202883 no 1280 0.374733107966148 403 1273210 SGTC_3273 9137859 49.47 µM 0.318856456425499 0.375836703096572 no 1281 0.374917682419407 429 2377234 SGTC_21 0849-0113 22.993 µM 0.316869549655151 0.376653091507402 no 1282 0.375671294079917 396 1560156 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.316337728719981 0.376871702067678 no 1283 0.375873088482216 389 66535 A nucleotide analog. SGTC_200 k038-0079 37.545 µM 0.314555009315105 0.377604795159026 no 1284 0.376549771789216 415 3436683 SGTC_475 α-linolenic acid 10 µM 0.312105565125238 0.378612779060554 no 1285 0.377480148643219 395 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1328 1441-0025 69.2 µM 0.311921951636167 0.378688372210435 no 1286 0.377549919620022 402 4562601 SGTC_909 3448-9333 149 µM 0.311623228381839 0.378811365639638 no 1287 0.377663439498627 399 3344074 SGTC_1656 st012921 11 µM 0.309401255472036 0.37972660371881 no 1288 0.378508157742913 418 6732821 SGTC_3150 9097574 49.47 µM 0.309042274177214 0.379874532709869 no 1289 0.378644684783642 431 17217476 SGTC_1973 st070275 50.2 µM 0.308865025702449 0.379947579735161 no 1290 0.378712101152316 407 17118334 SGTC_471 1-acyl-paf 4 µM 0.307793417669036 0.380389298255132 no 1291 0.379119765273642 386 16759367 SGTC_1112 tnp00069 1.16933 µM 0.307130428587215 0.380662661559459 no 1292 0.379372048798911 410 145826 SGTC_206 4546-0025 72.014 µM 0.30640528841611 0.380961719198781 no 1293 0.379648041153085 429 6620745 YIL048W NEO1 SGTC_3223 9129970 49.47 µM 0.306403956047063 0.380962268751355 no 1294 0.379648548316589 403 17248386 SGTC_743 1275-0778 158 µM 0.304561604918525 0.381722399187353 no 1295 0.380350033161978 422 2849257 YMR203W TOM40 SGTC_2664 lyso-paf C-16 73.48 µM 0.304392499254353 0.381792192922724 no 1296 0.380414440790372 413 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_762 1165-0429 115 µM 0.302589084782557 0.382536741474788 no 1297 0.381101516912049 434 5967793 SGTC_1792 st045773 43.6 µM 0.302382360203746 0.382622116539188 no 1298 0.381180300131983 401 2919270 SGTC_261 5-fluorouridine 15.376 µM 0.30151718598916 0.38297948619159 no 1299 0.381510073447753 386 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_73 0327-0325 16.231 µM 0.301344831413882 0.383050691040659 no 1300 0.38157577910166 393 53298 SGTC_2435 5706476 10.6 µM 0.300688113666082 0.383322037053273 no 1301 0.381826166750089 401 5725375 SGTC_2681 menadione 3.18 µM 0.299968776107904 0.383619322333958 no 1302 0.382100486278816 422 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_459 nigericin 15.3 µM 0.29942305252213 0.383844902766737 no 1303 0.38230863758095 418 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_511 blebbistatin 171 µM 0.299109677193336 0.383974457466012 no 1304 0.382428181387975 418 3476986 A myosin inhibitor. SGTC_1629 st005085 44.9 µM 0.297582782299092 0.384605887091799 no 1305 0.383010808636049 435 24207091 SGTC_460 trequinsin 123 µM 0.29756613564992 0.384612772810586 no 1306 0.383017162068007 408 5537 A vasodilator. SGTC_2830 7992007 71.43 µM 0.297001265101844 0.384846447385975 no 1307 0.38323277164147 389 1952075 SGTC_306 1672-3436 11.6 µM 0.295619415586729 0.385418264456824 no 1308 0.383760372260698 436 6797378 SGTC_1290 0986-0249 10.2 µM 0.294591328210229 0.385843854501708 no 1309 0.384153043717842 423 53329 SGTC_419 nsc-638432 893 µM 0.294227205531661 0.385994620772838 no 1310 0.384292146610387 392 368090 SGTC_278 4092-0821 23.9 µM 0.293715527388965 0.386206511997743 no 1311 0.38448764412659 411 877900 SGTC_1815 st051655 58.2 µM 0.293177608099416 0.386429306553661 no 1312 0.384693199312241 409 5984156 SGTC_1607 st000305 50.6 µM 0.292733857929782 0.38661312648373 no 1313 0.384862794042554 433 5457690 SGTC_2680 butyl paraben 22.24 µM 0.292732800278594 0.386613564637618 no 1314 0.384863198287475 427 7184 An antifungal and steroid mimetic. SGTC_2842 9000675 19.48 µM 0.292506349201283 0.386707380009501 no 1315 0.384949753048102 434 2989072 SGTC_2121 5257820 149.641 µM 0.290985297279294 0.387337700933298 no 1316 0.38553128213684 430 791256 SGTC_3207 9114163 49.47 µM 0.290746788310485 0.387436565571498 no 1317 0.38562249234769 440 849233 SGTC_2937 9044753 11.33 µM 0.290627144717892 0.387486161930221 no 1318 0.38566824863783 407 6465530 YGL099W LSG1 SGTC_2222 6885208 172.143 µM 0.288629564256996 0.388314497985656 no 1319 0.386432434458408 404 609514 SGTC_698 k064-0052 127 µM 0.287916298307988 0.388610391089227 no 1320 0.386705405347676 441 5088751 SGTC_2907 7721985 69.9 µM 0.28745192455716 0.388803067859703 no 1321 0.386883153933031 394 3267881 SGTC_2817 7995342 71.43 µM 0.284909953311151 0.389858259624621 no 1322 0.387856565124695 396 18879975 SGTC_1908 st060353 56.5 µM 0.283778426795685 0.39032822668928 no 1323 0.388290094044894 417 4227716 SGTC_2857 9024691 58.44 µM 0.282990516206616 0.390655571388457 no 1324 0.388592053478165 435 16478292 SGTC_2649 anisomycin 9.56 µM 0.282181062885463 0.390991946932698 no 1325 0.388902339084814 414 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1192 1488-0095 21.4 µM 0.282156055179197 0.391002340408201 no 1326 0.388911926352609 427 915875 SGTC_2422 chlorphenesin carbamate 384.24 µM 0.281407856006916 0.391313336121913 no 1327 0.389198796632089 384 2724 A muscle relaxant with antifungal properties. SGTC_2474 5321570 43.32 µM 0.279619729740778 0.392056868050838 no 1328 0.389884634271139 458 2841384 SGTC_2909 7941780 10.49 µM 0.279404306134719 0.392146471352293 no 1329 0.389967283403905 417 1243215 SGTC_3130 9127414 49.47 µM 0.278855037157416 0.392374960180236 no 1330 0.390178037710309 405 1494646 SGTC_859 0439-0102 54.6 µM 0.278397379571724 0.392565368191393 no 1331 0.390353665417004 425 610143 SGTC_2306 7482397 179.52 µM 0.277806395069635 0.392811284784116 no 1332 0.390580490898398 442 891448 SGTC_1414 3917-0015 5.4 µM 0.277626988923222 0.392885946563917 no 1333 0.390649356058761 450 6618702 SGTC_2460 5552655 174.22 µM 0.275997598443865 0.393564214889501 no 1334 0.391274955393921 400 5401989 SGTC_2171 5739187 198.077 µM 0.27501476004185 0.393973498567871 no 1335 0.391652449258646 396 2262761 SGTC_2244 6635614 200 µM 0.274986550034011 0.393985247800902 no 1336 0.391663285818506 400 836499 SGTC_154 3389-1638 511.116 µM 0.272731185869202 0.394924899537725 no 1337 0.392529930148583 451 5238686 SGTC_2182 6325192 200 µM 0.272523451142335 0.39501147883608 no 1338 0.392609781001164 435 736248 SGTC_2967 9089538 49.85 µM 0.272327835228528 0.395093012017191 no 1339 0.392684977653489 414 728216 SGTC_1707 st032323 6.317 µM 0.270998341392206 0.395647269758955 no 1340 0.39319615396162 407 3132057 YMR211W DML1 SGTC_1064 honokiol 6.76 µM 0.270115507388531 0.396015434491206 no 1341 0.393535696115421 417 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2705 st078069 42.8 µM 0.270026251826252 0.39605266155063 no 1342 0.393570028740399 424 1530061 SGTC_2309 7664088 163.95 µM 0.269447080322067 0.396294247689382 no 1343 0.393792830222593 443 704922 SGTC_1491 4138-0063 26.5 µM 0.268399978473791 0.396731119682022 no 1344 0.394195728039814 430 23883227 SGTC_3120 9124077 49.47 µM 0.267963713096181 0.396913176684391 no 1345 0.394363625163138 447 18774327 YGL155W CDC43 SGTC_2792 7535235 81.82 µM 0.267900007474789 0.396939763426549 no 1346 0.394388143972016 395 1281891 SGTC_1721 st082152 9.2685 µM 0.267474219247065 0.397117473097918 no 1347 0.394552030677537 405 5296051 SGTC_157 1348-1695 65.819 µM 0.267093893192608 0.397276226453376 no 1348 0.394698434688831 425 5380510 SGTC_1322 1348-1070 12 µM 0.265960766868927 0.397749309847672 no 1349 0.395134712297538 437 6758089 SGTC_2683 piperine 63.03 µM 0.265842702706621 0.397798610627977 no 1350 0.395180177071388 454 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2150 5556613 200 µM 0.264532157785879 0.398345972396048 no 1351 0.395684944362515 431 743190 SGTC_521 r062-0005 13.8 µM 0.262000118646284 0.39940406885853 no 1352 0.396660675358476 415 2832033 SGTC_1783 st039459 87.517 µM 0.261820993138763 0.399478950480763 no 1353 0.396729726652176 466 729761 SGTC_809 3998-0021 90 µM 0.261800395233591 0.399487561465595 no 1354 0.396737667169497 456 715485 SGTC_2033 5192550 145 µM 0.260715822547403 0.399941037657709 no 1355 0.397155831659631 425 182073 SGTC_2898 9056270 58.44 µM 0.260476655700906 0.400041055106781 no 1356 0.397248060019637 423 19154699 SGTC_1293 1000-1278 195 µM 0.259681829163929 0.400373491571076 no 1357 0.397554605072032 443 678847 SGTC_1271 0832-2808 169 µM 0.25883263075474 0.400728748851789 no 1358 0.397882189933222 452 3663794 SGTC_2038 4100038 30.985 µM 0.258242146256976 0.400975823075997 no 1359 0.398110016358225 433 3596803 SGTC_2788 5282734 71.43 µM 0.25740805570139 0.401324895949778 no 1360 0.398431892405373 430 743706 SGTC_2813 7971799 71.43 µM 0.257234420642236 0.401397573381166 no 1361 0.398498906977576 428 2234054 SGTC_95 0471-0001 561.058 µM 0.256135720325734 0.40185752906172 no 1362 0.398923020447377 381 4015405 SGTC_341 1486-1430 230 µM 0.255985036413307 0.401920621412992 no 1363 0.398981195833989 426 2054753 YPL210C SRP72 SGTC_1257 0669-0121 16 µM 0.255787627471425 0.402003281710904 no 1364 0.399057414011336 424 4307855 SGTC_833 3852-0053 558 µM 0.254285470541064 0.402632417517957 no 1365 0.399637511901837 429 3123681 SGTC_2740 felodipine 17.08 µM 0.252556614800831 0.403356811821485 no 1366 0.400305429817102 452 3333 L-type calcium channel blocker SGTC_1326 1431-2094 10.8 µM 0.249128930432531 0.404793997595529 no 1367 0.401630525780039 454 616278 SGTC_1899 st063254 59.6 µM 0.248547836935439 0.405037770874788 no 1368 0.401855281214106 435 3093813 SGTC_3343 9148379 18.9835 µM 0.245931800345569 0.406135673838178 no 1369 0.402867513276823 444 1955036 SGTC_1520 flindersine 88 µM 0.245009109209224 0.406523087147905 no 1370 0.403224689081164 444 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2092 5303694 80.6725 µM 0.2447417444392 0.406635363576076 no 1371 0.40332820168511 443 1963699 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.243480210859045 0.407165231928317 no 1372 0.403816706685032 448 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1053 3366-3204 134 µM 0.243162338203205 0.407298771396886 no 1373 0.40393982055396 413 3632071 YPR165W RHO1 SGTC_580 1123-0028 41 µM 0.241916994563971 0.407822048487429 no 1374 0.404422240719638 458 1677248 YPR107C YTH1 SGTC_1404 3909-7820 48.3 µM 0.240625427078018 0.408364921979544 no 1375 0.404922720584477 440 23741373 SGTC_2779 methotrexate 400 µM 0.240251304327354 0.408522206692824 no 1376 0.405067721507974 455 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_1285 0929-0069 65.5 µM 0.240103785024876 0.408584229243457 no 1377 0.405124900003247 415 1206237 SGTC_2725 haloperidol 53.21 µM 0.23968410583068 0.408760690359049 no 1378 0.405287578770525 453 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2013 4024628 200 µM 0.239294935759748 0.408924339934807 no 1379 0.405438446017946 434 5230760 SGTC_260 nsc-65238 3.989 µM 0.238052393437144 0.40944694649445 no 1380 0.405920228951308 426 3246252 SGTC_658 3253-0951 102 µM 0.236879267743711 0.409940504539387 no 1381 0.406375227123042 454 1184878 SGTC_733 4069-0007 56.1 µM 0.236866008025412 0.409946083992047 no 1382 0.406380370644141 442 5717425 YNL287W SEC21 SGTC_1428 4049-0204 61.7 µM 0.235709483972223 0.410432798688743 no 1383 0.406829055043766 446 X1428 SGTC_1358 1509-0022 2.48 µM 0.232675333450417 0.411710352766773 no 1384 0.408006762309725 411 3258434 SGTC_2746 daunorubicin 9.88 µM 0.2323412732883 0.411851069027053 no 1385 0.408136478966656 453 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3161 9100388 49.47 µM 0.231708560504047 0.412117617874104 no 1386 0.408382190999438 436 25236368 SGTC_3293 9120939 62.045 µM 0.231680726762632 0.41212934458731 no 1387 0.408393000973882 442 934087 SGTC_2266 7929956 200 µM 0.23135076363317 0.41226836827261 no 1388 0.408521156248499 427 2967153 SGTC_1641 st009299 47.1 µM 0.231278980574996 0.412298614156782 no 1389 0.408549037561268 434 4046054 SGTC_1300 1094-0077 113 µM 0.230597696423495 0.412585700019861 no 1390 0.408813678687029 429 5532636 SGTC_782 0083-0095 30.5 µM 0.229287254171698 0.413138037758901 no 1391 0.409322829662281 424 3591729 An indicator and reagent. SGTC_3053 9095903 49.47 µM 0.228535778503012 0.41345485457286 no 1392 0.409614872365364 465 17174018 SGTC_2894 9048625 32.47 µM 0.228481350100082 0.413477803392796 no 1393 0.409636026587527 470 4092861 SGTC_1900 st060200 72.8 µM 0.227684366922264 0.413813871745714 no 1394 0.409945813325347 424 688945 SGTC_275 trichlorophene 5.69 µM 0.227455118956483 0.413910551719877 no 1395 0.410034932249882 450 62616 SGTC_603 3794-0023 45.9 µM 0.227097195795446 0.414061507882952 no 1396 0.410174082260637 433 3802260 SGTC_1964 st076914 61 µM 0.227086661943142 0.414065950788541 no 1397 0.410178177684399 460 24208661 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.225895090540303 0.414568595543068 no 1398 0.410641508161891 479 1273210 SGTC_1807 st050092 58.9 µM 0.224810961454641 0.415026039121934 no 1399 0.411063169166573 443 5008496 SGTC_524 r073-0010 27.8 µM 0.224797872290236 0.415031562743484 no 1400 0.411068260693123 452 2772106 SGTC_2586 curcumin 80 µM 0.222169127748893 0.416141230758701 no 1401 0.412091113023908 417 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_3244 9134489 49.47 µM 0.221032506940219 0.416621238441929 no 1402 0.412533561000718 453 16584271 SGTC_1743 st037606 46.3785 µM 0.220259066342524 0.416947942203455 no 1403 0.412834698820141 415 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2766 oltipraz 83.91 µM 0.219168476605143 0.417408708186089 no 1404 0.413259405268836 422 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_3147 9097027 49.47 µM 0.218820311577419 0.41755582921589 no 1405 0.413395011967523 451 25236841 SGTC_1098 clofazimine 15.1 µM 0.218130507333446 0.417847347786916 no 1406 0.413663714125993 442 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_342 k048-0088 23.3 µM 0.218121837608527 0.417851011992001 no 1407 0.41366709153556 436 6820570 SGTC_2993 9054257 71.4286 µM 0.217215568132772 0.418234080402958 no 1408 0.414020176351027 458 6470217 YGL055W OLE1 SGTC_1026 k007-1105 30.6 µM 0.217162407733493 0.418256553029743 no 1409 0.414040889934327 409 7066794 SGTC_2364 9055074 200 µM 0.215969739375024 0.418760802686107 no 1410 0.414505667701878 440 6470630 SGTC_3136 9095672 49.47 µM 0.214642752238663 0.419321998013093 no 1411 0.415022929614784 460 17217380 SGTC_1244 0416-0015 52.5 µM 0.213757465934424 0.419696485271744 no 1412 0.415368097765812 449 96201 SGTC_1619 st003326 88.7 µM 0.213026741844681 0.420005645578171 no 1413 0.41565305220268 440 2849032 SGTC_870 0573-2213 57.6 µM 0.212712838636494 0.420138469305766 no 1414 0.415775476073399 433 3916321 SGTC_1464 k208-0027 110 µM 0.212575098143165 0.420196755130465 no 1415 0.415829198157639 488 X1464 SGTC_1232 0279-0259 161 µM 0.21246700144192 0.420242498209083 no 1416 0.415871359556202 450 1560000 SGTC_2250 alverine citrate 130 µM 0.211805169620895 0.420522587808566 no 1417 0.41612951762494 456 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_409 arachidonic acid 100 µM 0.211490819122349 0.420655636172389 no 1418 0.416252147739613 432 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_34 0469-0683 81.75 µM 0.210149185456944 0.421223582271713 no 1419 0.416775619016901 439 3690923 SGTC_1811 st050069 61.5 µM 0.209377502079506 0.421550328928877 no 1420 0.417076777137952 476 3877702 SGTC_789 1309-1135 70.6 µM 0.208253603422581 0.42202630738089 no 1421 0.417515478236574 424 3092424 SGTC_1979 st071809 45.3 µM 0.207659923451906 0.422277780766939 no 1422 0.417747255965923 468 4976333 SGTC_1164 k060-0068 93.7 µM 0.205973722899622 0.422992200959614 no 1423 0.418405718640604 439 5963676 SGTC_2864 9034755 47.6 µM 0.205938737593177 0.423007026447672 no 1424 0.418419382859268 430 4930451 SGTC_894 0960-0238 55.9 µM 0.205120914993151 0.42335362065325 no 1425 0.418738828023153 474 6741907 YDL195W SEC31 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.204541923242603 0.42359903393631 no 1426 0.41896501720298 454 279621 SGTC_2821 7996764 71.43 µM 0.20377179717129 0.423925507935289 no 1427 0.419265916504326 423 2987135 SGTC_3168 9103419 49.47 µM 0.203027842196573 0.424240937000398 no 1428 0.41955663522861 475 16649256 SGTC_2991 9074669 71.4286 µM 0.202901981987616 0.424294305207314 no 1429 0.419605822551562 476 17333109 SGTC_2687 chenodiol 100 µM 0.202474346276973 0.424475644932051 no 1430 0.419772955885946 434 5702181 A cholesterol synthesis inhibitor. SGTC_3205 9113483 49.47 µM 0.202047517717848 0.424656658325201 no 1431 0.419939788191398 492 17018033 SGTC_742 0kpi-0133 140 µM 0.201149191290499 0.425037680754457 no 1432 0.420290959440393 470 2728852 SGTC_1736 st036774 51 µM 0.199794337468653 0.425612470256498 no 1433 0.420820715044657 463 1272247 SGTC_1673 st016611 27.3 µM 0.199568757739592 0.425708186639921 no 1434 0.420908931963361 466 5226799 SGTC_153 4077-0274 519.67 µM 0.198326117524895 0.426235533216211 no 1435 0.421394959345415 472 3121976 SGTC_3296 9122258 64.045 µM 0.1978679390731 0.426430006453652 no 1436 0.421574194558539 455 4730474 SGTC_2153 5569715 200 µM 0.197713846695651 0.426495414781547 no 1437 0.421634477738367 469 2054701 SGTC_1063 disulfiram 1.84 µM 0.197327249486029 0.426659524441506 no 1438 0.421785728272198 437 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_673 1082-0474 110 µM 0.196767373996653 0.426897212850064 no 1439 0.422004791861836 469 3098046 SGTC_2168 5727979 200 µM 0.194385213239464 0.42790882630336 no 1440 0.422937133611856 461 695210 SGTC_2016 5121758 140 µM 0.193548011792717 0.428264466968119 no 1441 0.423264904428349 477 2795203 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.193144638379201 0.428435839604441 no 1442 0.423422847202246 447 6708784 An antioxidant flavonoid SGTC_3198 9112019 49.47 µM 0.192332453503085 0.428780936136448 no 1443 0.423740899351588 486 45595555 SGTC_1239 0337-0584 35.4 µM 0.191826800302095 0.428995815191961 no 1444 0.423938938598103 468 914301 YML130C ERO1 SGTC_1518 st038567 90.8 µM 0.191384327562028 0.429183862762242 no 1445 0.424112248957304 480 77966 SGTC_635 k038-0028 24.7 µM 0.190767980576411 0.429445832351847 no 1446 0.424353687871185 471 4035102 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.189979169591764 0.42978115064898 no 1447 0.424662726759684 461 676296 Flavone; oxidizing agent. SGTC_3019 9081971 49.47 µM 0.187550270412491 0.430813976651177 no 1448 0.425614606392832 453 16451803 SGTC_988 1497-1057 103 µM 0.187129980038424 0.430992742407344 no 1449 0.42577936132952 474 3533044 SGTC_3118 9124250 49.47 µM 0.186879271024177 0.431099385385423 no 1450 0.42587764609744 474 1504786 SGTC_1029 k015-0030 64.7 µM 0.186878275314936 0.431099808935854 no 1451 0.42587803645179 440 2208316 SGTC_123 0083-0120 66.675 µM 0.186575831680662 0.431228464747838 no 1452 0.425996608750947 468 16001701 SGTC_2074 5212007 75.395 µM 0.186292027482588 0.431349198209058 no 1453 0.426107879589405 494 758611 SGTC_2111 5486399 200 µM 0.186218594672758 0.431380438387808 no 1454 0.426136671278785 445 689674 SGTC_2885 9057732 51.95 µM 0.18425071345861 0.432217784211078 no 1455 0.426908388423142 452 6471414 SGTC_1879 gemcitabine 100 µM 0.184058658553524 0.432299521152686 no 1456 0.426983719012558 456 60750 A nucleoside analog which inhibits DNA replication. SGTC_1205 4161-2785 76 µM 0.184042480042612 0.432306406722332 no 1457 0.42699006490685 419 3498106 SGTC_1625 st003711 30.1 µM 0.182546001146268 0.432943396349752 no 1458 0.427577128536789 457 24207034 YER133W GLC7 SGTC_1682 st012968 530 nM 0.182492361686785 0.432966231710615 no 1459 0.427598174101229 443 24207270 SGTC_2592 piperlongumine 83.33 µM 0.180641583877717 0.433754280405556 no 1460 0.428324456786741 451 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1569 carminic acid 40.6 µM 0.180226461259772 0.433931073090386 no 1461 0.428487392737444 485 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2450 5739737 12.93 µM 0.180192439632971 0.433945562828953 no 1462 0.428500746793305 476 2262825 SGTC_3004 9076122 71.4286 µM 0.179158758320091 0.434385847731031 no 1463 0.428906522906755 475 44782551 SGTC_2302 7771753 200 µM 0.178835279112091 0.434523646800614 no 1464 0.429033521541463 460 2203047 SGTC_3048 9093155 49.47 µM 0.177150414169781 0.435241511513087 no 1465 0.42969512165292 480 25236002 SGTC_2760 etidronate 98.04 µM 0.176760437642869 0.435407698005166 no 1466 0.429848282919953 466 3305 A chelator and antioxidant. SGTC_2669 eugenol 100 µM 0.176498075369596 0.435519508760418 no 1467 0.429951330290217 469 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1382 3002-2117 298 µM 0.176021009842516 0.435722832661002 no 1468 0.43013871833999 478 1497314 SGTC_2424 5537928 59.2 µM 0.174217416248898 0.436491671960062 no 1469 0.430847299327185 478 5382802 SGTC_1301 naphtanilide LB 4.81 µM 0.173185653056478 0.436931602032673 no 1470 0.431252750221535 469 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.172856077228248 0.437072145236876 no 1471 0.43138227857608 493 7104 SGTC_2401 5128683 200 µM 0.172383815490354 0.437273548778429 no 1472 0.43156789754088 469 708373 SGTC_203 k066-0004 30.888 µM 0.172089160063006 0.437399217518069 no 1473 0.431683717324109 479 6795412 SGTC_1228 0124-0032 52.5 µM 0.171709829622084 0.437561008930823 no 1474 0.431832828838361 449 X1228 SGTC_2207 7258803 200 µM 0.171621482992355 0.437598691893933 no 1475 0.431867558529341 472 3666799 SGTC_2275 7947463 200 µM 0.170980607688717 0.437872064807517 no 1476 0.432119506935732 486 1225414 SGTC_1234 0326-0494 15.5 µM 0.170432508113784 0.438105886672 no 1477 0.432335004168119 483 1547813 SGTC_2157 5649910 96.377 µM 0.170131884871314 0.438234143147668 no 1478 0.432453209267322 463 2858091 SGTC_381 3461-2219 42.7 µM 0.170031749833739 0.438276865726707 no 1479 0.432492583720319 470 2883159 SGTC_1298 1079-1278 263 µM 0.169410078052793 0.438542117853168 no 1480 0.432737048470367 479 2840950 SGTC_198 3454-2873 16.191 µM 0.168381022623947 0.438981251224959 no 1481 0.43314176834959 482 710957 SGTC_370 0180-0345 38.7 µM 0.167408008312478 0.439396539023503 no 1482 0.433524512187533 435 3989527 SGTC_1455 4262-0120 131 µM 0.165915349602391 0.440033743380325 no 1483 0.434111783841844 446 1529587 SGTC_1351 1496-0003 46.5 µM 0.163389287227284 0.441112452775759 no 1484 0.435105968548509 472 3891978 SGTC_87 0100-0052 35.5 µM 0.1627173911156 0.44139944780822 no 1485 0.435370476677868 487 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1697 st025554 27.742 µM 0.160004438935787 0.44255857500994 no 1486 0.436438788752822 464 1269519 SGTC_3133 9127736 49.47 µM 0.159772964426607 0.442657496976975 no 1487 0.436529960861289 460 27243420 SGTC_2009 4012297 12.05 µM 0.159335050607447 0.442844651748611 no 1488 0.436702453549684 446 45595307 SGTC_410 α-linolenic acid 100 µM 0.159047639377402 0.442967491946056 no 1489 0.436815670350152 491 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2628 lathosterol 100 µM 0.158882690312107 0.443037994019335 no 1490 0.436880649291292 447 6710616 SGTC_721 1187-1332 279 µM 0.157946345519171 0.443438238032709 no 1491 0.437249538971091 487 25730 SGTC_1370 2001-0092 44.6 µM 0.154958793334915 0.444715662032691 no 1492 0.438426901492443 490 790957 SGTC_1124 fisetin 1.16336 µM 0.153919439102247 0.445160206706819 no 1493 0.438836628282434 454 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2062 5245942 200 µM 0.153724273973023 0.445243688957376 no 1494 0.438913572206696 463 1376160 SGTC_1765 st044815 90.4 µM 0.153046921045006 0.445533446760054 no 1495 0.43918063673978 481 645695 SGTC_3031 9088762 49.47 µM 0.15287621968702 0.445606473924727 no 1496 0.439247944694647 448 205253 SGTC_2483 5729050 27.16 µM 0.152391517916023 0.445813842585028 no 1497 0.439439073333831 495 2865180 SGTC_2626 ethyl orsellinate 100 µM 0.152140887102534 0.445921075112427 no 1498 0.439537908152642 478 75653 A natural product. SGTC_1416 3966-0321 25.3 µM 0.151945535337416 0.446004659213101 no 1499 0.439614946610766 463 582530 YLR208W SEC13 SGTC_2265 7929201 200 µM 0.150090358654059 0.446798542681252 no 1500 0.44034666324997 494 1265108 SGTC_993 3909-8757 62.7 µM 0.149498859341037 0.447051707239839 no 1501 0.44058000468378 456 4288324 YLR208W SEC13 SGTC_3303 9125618 40.5795 µM 0.149227171087412 0.447167998360525 no 1502 0.440687190303073 470 22695467 SGTC_2076 5212012 200 µM 0.149156199058888 0.447198377370423 no 1503 0.440715190687009 474 604802 SGTC_2007 4011539 71.82 µM 0.149131307356219 0.44720903213831 no 1504 0.440725011206861 476 45595301 SGTC_48 0382-0018 55 µM 0.14857352889074 0.447447796377801 no 1505 0.440945081014002 422 762596 SGTC_1211 1056-0033 32.3 µM 0.148533959949854 0.447464735095882 no 1506 0.440960693513584 487 6741922 SGTC_1708 st033234 31.827 µM 0.147117847487692 0.448071009003646 no 1507 0.44151950144989 449 674664 SGTC_1386 3228-0095 33.8 µM 0.145766613504704 0.448649619911343 no 1508 0.442052816450076 492 870181 SGTC_611 3453-1652 23.7 µM 0.145540965899293 0.448746254983896 no 1509 0.442141886974549 476 1560575 SGTC_1050 3232-1156 69.3 µM 0.144819770241156 0.449055132135317 no 1510 0.442426586192377 492 700529 SGTC_36 0335-0881 14.2 µM 0.144758111955254 0.449081540878485 no 1511 0.442450927800896 473 23828853 SGTC_601 0986-0029 62.9 µM 0.143500936668037 0.449620048260681 no 1512 0.442947285775871 477 24747981 SGTC_582 0987-0078 156 µM 0.142796982091765 0.449921625750321 no 1513 0.443225260298986 493 1625765 SGTC_2467 5474540 200 µM 0.142258714212598 0.450152241793181 no 1514 0.443437828039006 480 5413519 SGTC_1173 0443-0020 122 µM 0.141507051693416 0.45047431300473 no 1515 0.443734694827033 470 5331295 SGTC_1387 3342-1166 1.8 µM 0.141184363149815 0.450612588119559 no 1516 0.443862149367386 468 3418228 SGTC_824 1304-0008 100 µM 0.13940531142544 0.451375035911523 no 1517 0.444564937716979 472 768245 SGTC_1159 4092-0538 61.2 µM 0.138500040352569 0.451763076783373 no 1518 0.444922618863416 468 717301 SGTC_94 0334-0113 514.748 µM 0.138271979163636 0.451860841594599 no 1519 0.445012735075817 500 6795178 SGTC_2946 9065502 71.43 µM 0.137834411021171 0.452048425593795 no 1520 0.445185643923651 459 16489101 SGTC_305 1682-2595 20.8 µM 0.137345676785142 0.452257956980524 no 1521 0.445378783825059 482 226033 SGTC_274 sirtinol 40.1 µM 0.136944993271584 0.452429748959612 no 1522 0.445537137172373 448 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1785 bathophenanthroline 24 µM 0.136892535384997 0.452452240797433 no 1523 0.445557869594891 461 72812 An iron chelator. SGTC_2526 patulin 37.61 µM 0.136705395000393 0.452532480331209 no 1524 0.445631832489403 457 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1437 4092-1038 11.6 µM 0.136392703835223 0.452666556161877 no 1525 0.445755420637598 494 3977136 SGTC_1888 azatryptophan 97.5 µM 0.135491618564408 0.453052953962299 no 1526 0.446111595284349 443 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2972 9093619 59.92 µM 0.13243602168081 0.454363564904757 no 1527 0.447319712206857 414 25236256 SGTC_338 4055-0136 114 µM 0.132385578086613 0.454385205452155 no 1528 0.447339660646406 455 2900563 SGTC_1931 st074438 57.1 µM 0.132198999252134 0.454465249856264 no 1529 0.447413446327915 504 2787313 SGTC_85 0868-0259 160.055 µM 0.132073632205544 0.454519034758521 no 1530 0.447463025819419 484 83173 SGTC_96 0929-0093 37.281 µM 0.131388747726381 0.454812878221855 no 1531 0.447733894755953 473 6991579 SGTC_696 1560-0013 611 µM 0.131324993713999 0.454840232562167 no 1532 0.447759110442283 465 1650269 SGTC_121 0557-0495 61.343 µM 0.130522984455041 0.455184361454269 no 1533 0.448076335361818 500 3104427 SGTC_1775 st081588 35.1725 µM 0.129526494012955 0.455611985827839 no 1534 0.448470531168782 492 1426443 YGL099W LSG1 SGTC_1018 4259-0013 28.1 µM 0.129413832130882 0.455660335715101 no 1535 0.448515101630389 473 6801262 SGTC_3055 9094636 49.47 µM 0.12894248599015 0.455862625377575 no 1536 0.448701579149232 497 25236176 SGTC_2459 5811157 9.22 µM 0.126050805989881 0.457103908675201 no 1537 0.44984585395035 468 2870684 YBR192W RIM2 SGTC_224 benfluorex 43.875 µM 0.125992170998203 0.457129082717888 no 1538 0.449869060914323 501 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_879 0831-1030 162 µM 0.124730443853055 0.457670827608387 no 1539 0.450368477447934 502 1549252 SGTC_3298 9116858 71.43 µM 0.124527541484622 0.457757954700762 no 1540 0.4504487975713 488 2506942 SGTC_2097 5376186 200 µM 0.122841195487499 0.458482156603826 no 1541 0.451116425999703 454 742755 SGTC_1255 0566-0045 221 µM 0.121531737488058 0.459044599011906 no 1542 0.451634939061996 490 2788469 SGTC_1 0258-0098 57.368 µM 0.120903857415045 0.459314317134706 no 1543 0.451883593405933 464 6790032 YDR047W HEM12 SGTC_727 3032-0951 202 µM 0.119427014166738 0.459948797547808 no 1544 0.452468530119661 490 3652836 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.119155413082028 0.460065493777412 no 1545 0.452576115057648 498 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1049 3226-0134 66 µM 0.116959633671763 0.461009058689438 no 1546 0.453446020767394 485 5702385 SGTC_481 bay k-8644 50 µM 0.115633262913074 0.461579130169982 no 1547 0.453971599866742 490 2303 A calcium channel antagonist. SGTC_2544 sphondin 68.51 µM 0.115540907129993 0.461618827453075 no 1548 0.454008199184705 505 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1645 Cervolide 78 µM 0.115239874671428 0.461748222876956 no 1549 0.454127496889098 484 23173 A fragrance. SGTC_1084 voriconazole 435 nM 0.112623802414335 0.462872881196858 no 1550 0.455164406755523 515 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2957 9076800 11.52 µM 0.112243574104086 0.463036367554954 no 1551 0.455315140150852 481 16459615 SGTC_3349 9149703 23.001 µM 0.111623797937926 0.463302865417683 no 1552 0.455560850958686 488 4910494 SGTC_549 1661-1316 519 µM 0.110939428378637 0.463597156954669 no 1553 0.45583218961958 496 2857282 SGTC_3129 9127257 49.47 µM 0.110704576085438 0.463698152372952 no 1554 0.45592530854865 488 837894 SGTC_509 pifithrin 175 µM 0.1092902447333 0.464306417885133 no 1555 0.456486141911255 503 4817 A p53 inhibitor. SGTC_1376 2910-0861 41.3 µM 0.108562833781947 0.46461929016393 no 1556 0.456774620404814 482 1112859 SGTC_3323 9138564 53.9225 µM 0.108434493497486 0.464674493859634 no 1557 0.456825520291376 464 43912313 YNL103W MET4 SGTC_1449 4112-4002 201 µM 0.106332739651291 0.465578628502714 no 1558 0.457659178172998 473 2059539 SGTC_783 0848-0141 92.7 µM 0.106163969586305 0.465651237953683 no 1559 0.457726128726233 485 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2706 st078239 82.5 µM 0.10386791195686 0.466639176703044 no 1560 0.458637085942528 510 15434492 SGTC_351 caspofungin 25 nM 0.102947327058607 0.467035340472339 no 1561 0.45900238782645 486 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2686 alizarin 95.37 µM 0.101908816134869 0.467482291614774 no 1562 0.45941452606743 469 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2804 7954240 19.48 µM 0.10080412665291 0.467957769471474 no 1563 0.459852975467525 492 828705 SGTC_545 4218-0007 221 µM 0.100542750355124 0.468070277157993 no 1564 0.459956722444005 495 2840508 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.0993651692691525 0.468577190592548 no 1565 0.460424168380833 495 2374 Ca(2+)-ATPase inhibitor. SGTC_147 4466-0538 29.23 µM 0.098588995383353 0.468911338143114 no 1566 0.460732303931352 460 6742687 YHR072W ERG7 SGTC_2958 9077254 16.72 µM 0.0982063856425127 0.469076062022964 no 1567 0.460884205984246 494 16457351 SGTC_1155 4088-0394 48.2 µM 0.097155241082692 0.469528635454718 no 1568 0.461301556133947 508 2326248 SGTC_2418 pentamidine 31.67 µM 0.0968857311447352 0.469644680128694 no 1569 0.461408570195439 501 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_447 ml7 120 µM 0.0964647175704951 0.469825963880268 no 1570 0.461575747254721 496 4216 Selective myosin light chain kinase inhibitor. SGTC_10 0279-0212 42.575 µM 0.0963246610664892 0.469886272037825 no 1571 0.4616313627269 484 39851 YBR002C RER2 SGTC_2796 7949634 45.45 µM 0.096226746867242 0.469928434181396 no 1572 0.461670244226084 495 2971588 SGTC_948 3448-0295 75.3 µM 0.0957328434765124 0.470141115571191 no 1573 0.461866377682759 475 678569 SGTC_251 melphalan 456.522 µM 0.0941627971327805 0.470817254761604 no 1574 0.462489918505767 506 460612 A DNA alkylator. SGTC_3001 9076041 71.4286 µM 0.0936128875457222 0.47105409287597 no 1575 0.462708335896453 482 16004211 SGTC_1133 3473-0247 50 µM 0.0932968112226765 0.471190227020637 no 1576 0.462833882655507 513 711311 SGTC_2083 5306046 65.942 µM 0.0929978398615928 0.471318997152678 no 1577 0.46295263866376 495 539837 SGTC_1506 4226-2149 212 µM 0.0923445810647417 0.471600373051632 no 1578 0.463212134548261 496 991114 SGTC_3003 9075612 71.4286 µM 0.0919279974652727 0.471779814073902 no 1579 0.463377623439841 508 6501993 SGTC_2865 9030313 51.95 µM 0.0917205676630776 0.471869165423135 no 1580 0.463460027820212 517 42562754 SGTC_1052 3253-3998 198 µM 0.0910011239444636 0.472179080084015 no 1581 0.463745848992544 493 5450317 SGTC_3174 9107204 49.47 µM 0.0905511886349238 0.472372907222041 no 1582 0.4639246091704 478 3938802 SGTC_1131 3454-3128 32.3 µM 0.0905483191134966 0.472374143401071 no 1583 0.463925749260282 495 710982 SGTC_2591 skatole 100 µM 0.0894806618158385 0.472834104512787 no 1584 0.464349960781283 507 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1681 tripelennamine 100 µM 0.0889150568348254 0.47307778945755 no 1585 0.46457470866242 492 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1261 0712-0010 12.7 µM 0.0886625742264628 0.473186572186518 no 1586 0.464675038396838 504 2840123 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.0885472640343769 0.473236254521183 no 1587 0.464720860284339 508 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3338 9144300 39.5675 µM 0.0868738054770957 0.473957324233038 no 1588 0.465385910492167 498 4901274 SGTC_2017 5132927 60.65 µM 0.0847420218999553 0.4748760030131 no 1589 0.466233243728227 495 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2694 st077685 81.9 µM 0.08452500006365 0.474969534788736 no 1590 0.466319513392878 488 2838096 SGTC_1604 st002052 72.4 µM 0.0843903648121689 0.475027560399858 no 1591 0.466373033862848 506 6254834 YHR062C RPP1 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.0840933455967807 0.47515557273888 no 1592 0.466491107674696 468 6708561 SGTC_2043 5101342 149 µM 0.0838650463848302 0.475253969181282 no 1593 0.466581865283543 500 678451 SGTC_953 1188-0045 9.7 µM 0.0837137286359053 0.475319187619833 no 1594 0.466642020794504 506 6144426 SGTC_1896 st058441 89 µM 0.0830370018295838 0.475610867126452 no 1595 0.466911058994741 471 688759 SGTC_2170 morpholine 200 µM 0.0818916525447978 0.476104559720335 no 1596 0.467366436224369 498 121171 Reacts with secondary amines. SGTC_389 tpck 16.7 µM 0.0809496460935612 0.47651063072613 no 1597 0.467740998804443 475 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_424 splitomicin 100 mM 0.0806071785326567 0.476658264389644 no 1598 0.467877178571095 497 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2987 9018338 71.43 µM 0.0804030087925552 0.47674628104483 no 1599 0.467958366991992 509 5055682 SGTC_1892 st058411 7.36 µM 0.0798849940816473 0.476969599933841 no 1600 0.468164362335972 519 3934738 SGTC_2934 9036370 36.88 µM 0.0788643912082107 0.477409608342225 no 1601 0.468570243345561 503 6462800 SGTC_1420 4'-methoxyflavone 42 µM 0.0787124204406767 0.477475129256265 no 1602 0.468630683025561 514 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1191 1487-1166 10.6 µM 0.0777883382654004 0.477873552531602 no 1603 0.468998211527693 522 3955771 SGTC_1013 4112-3890 241 µM 0.0777408860239644 0.477894012435228 no 1604 0.469017085079393 522 705171 SGTC_950 1165-0508 94.1 µM 0.0776107603324145 0.477950118810945 no 1605 0.469068841347144 502 6148369 SGTC_1790 st045711 43.5 µM 0.0772798959514417 0.478092779778484 no 1606 0.469200441889363 508 585119 SGTC_276 colchicine 750 µM 0.0760978931692667 0.478602454478218 no 1607 0.469670608144928 514 2833 A microtubule depolymerizer. SGTC_2688 kanamycin b 96.69 µM 0.0744377674056209 0.47931835272572 no 1608 0.470331029051635 511 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3045 9092950 49.47 µM 0.0743365821649674 0.479361989152741 no 1609 0.470371284592006 502 44120432 SGTC_602 3130-1533 38.1 µM 0.0741125925198954 0.479458586212633 no 1610 0.470460397718203 522 720941 SGTC_285 1486-1325 46 µM 0.0738601380194066 0.479567460381168 no 1611 0.470560837213507 498 22310230 SGTC_801 0866-0028 10.1 µM 0.0737594045843496 0.479610903363957 no 1612 0.470600914722189 520 6849771 SGTC_98 0074-0023 107.663 µM 0.069986341006376 0.48123827021634 no 1613 0.472102265638065 527 3563821 SGTC_2286 7945697 125 µM 0.0695149598034187 0.48144160502255 no 1614 0.472289862628829 499 1245733 SGTC_1076 itraconazole 331 nM 0.0678759436465489 0.482148647613339 no 1615 0.472942194383893 508 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1786 berberine 21.6 µM 0.0677929324075546 0.482184458706782 no 1616 0.472975234971038 518 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_488 nitrendipine 139 µM 0.0670424314374511 0.482508231721077 no 1617 0.473273961882126 524 4507 Dihydropyridine L-type calcium channel blocker. SGTC_327 1273-0057 3.96 µM 0.066791119641676 0.482616652527763 no 1618 0.473373996561461 528 3108138 SGTC_3105 9121040 49.47 µM 0.0656795509416252 0.483096220237646 no 1619 0.473816476618956 520 41448907 SGTC_596 1155-0152 116 µM 0.0655576687809439 0.483148805756158 no 1620 0.47386499599611 528 280313 SGTC_2172 5754775 163.918 µM 0.064570155056665 0.483574874908765 no 1621 0.4742581239592 529 2263357 SGTC_3091 9116372 49.47 µM 0.0645409852391478 0.483587460701887 no 1622 0.474269736809669 483 17169793 SGTC_2708 st078559 56 µM 0.0641240649220724 0.483767349548053 no 1623 0.474435720119494 526 17250902 SGTC_1447 4239-0816 81.9 µM 0.0631303797174833 0.484196108722469 no 1624 0.474831341512251 490 1341554 SGTC_1833 st055984 71 µM 0.0630257006894546 0.484241277111017 no 1625 0.474873019405038 507 676288 SGTC_2164 5685496 200 µM 0.0620191104021315 0.484675625171291 no 1626 0.475273806697745 500 759046 SGTC_2070 5230947 200 µM 0.0615805531677964 0.484864870231046 no 1627 0.475448431934873 516 2835538 SGTC_429 1112-0049 25.5 µM 0.0613886496978342 0.484947680984451 no 1628 0.47552484577033 511 2836170 SGTC_2183 6420625 130.508 µM 0.0603519197907049 0.48539506487924 no 1629 0.475937675629454 499 2897619 SGTC_158 k038-0087 26.446 µM 0.0601312416032586 0.4854902973466 no 1630 0.476025553886645 485 X158 SGTC_1857 st056007 79.3 µM 0.0596685349913766 0.485689978539815 no 1631 0.476209816252837 515 619834 SGTC_336 4111-0029 111 µM 0.0592482693092768 0.485871347446504 no 1632 0.476377181895559 521 3131175 SGTC_860 0443-0016 25.1 µM 0.0591424574595064 0.485917011830964 no 1633 0.476419320822149 514 5337942 SGTC_2730 imipramine 71.33 µM 0.0589008864042023 0.486021265434838 no 1634 0.476515526015406 528 3696 A tricyclic antidepressant. SGTC_2582 agaric acid 100 µM 0.0582031384521676 0.486322394344872 no 1635 0.476793410419557 516 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1185 1319-0113 81.3 µM 0.0581884753162725 0.486328722637083 no 1636 0.476799250266994 522 4672763 SGTC_386 1509-0011 3.07 µM 0.0580823195334951 0.486374537278805 no 1637 0.476841528791752 518 3107280 SGTC_1753 st043925 64 µM 0.0572974021656358 0.486713296932254 no 1638 0.477154144863421 521 670181 SGTC_1405 3909-7894 12 µM 0.0572621072276286 0.486728529974225 no 1639 0.477168202426326 527 7104060 SGTC_3248 9135562 49.47 µM 0.0570906264577469 0.486802540119156 no 1640 0.477236501624618 491 17650701 SGTC_905 2-aminofluorene 215 µM 0.0562428467999873 0.487168443725622 no 1641 0.477574174175625 523 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1647 st011722 22.4 µM 0.0543694300563385 0.487977052473401 no 1642 0.47832041704907 504 2854783 SGTC_3311 9131146 2.8755 µM 0.0538680172896902 0.488193482008626 no 1643 0.4785201590794 502 4900406 YPR165W RHO1 SGTC_2155 5570423 76 µM 0.0534772347303755 0.488362161595129 no 1644 0.47867583437134 512 797402 SGTC_140 0062-0056 502.533 µM 0.0504705983194773 0.489660030455475 no 1645 0.479873689338165 521 3758964 SGTC_2472 5377652 49.4 µM 0.0501709676575316 0.489789377662973 no 1646 0.47999307343047 518 1610903 SGTC_271 rotenone 740 µM 0.050042479478694 0.489844844903309 no 1647 0.480044268489848 529 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1202 1988-0068 29.6 µM 0.0473410533699203 0.491011071105563 no 1648 0.481120704443843 529 2850480 SGTC_2552 juarezic acid 87.02 µM 0.0466593210686362 0.491305392662485 no 1649 0.481392376048036 523 1549512 SGTC_97 0535-0701 19.132 µM 0.0455680126946224 0.491776548644974 no 1650 0.481827282424176 505 2832013 YGL099W LSG1 SGTC_2978 9011784 42.97 µM 0.0448272493839056 0.492096368644211 no 1651 0.482122502526168 507 2994934 SGTC_1613 st002381 52.1 µM 0.0435411746847023 0.492651635426654 no 1652 0.48263507148988 533 551167 SGTC_3137 9097352 49.47 µM 0.0433495833882564 0.492734356814166 no 1653 0.482711433258 527 44120435 SGTC_192 3455-0609 60.9 µM 0.0432658356559482 0.492770515802539 no 1654 0.482744812452312 516 3769639 SGTC_265 mycophenolic acid 32.932 µM 0.0432086128159506 0.492795222416218 no 1655 0.482767619733999 528 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_2815 7968870 71.43 µM 0.0416063895243515 0.493487011467399 no 1656 0.483406239775243 523 2977326 YHR190W ERG9 SGTC_1496 4469-0713 57.4 µM 0.0410113315878055 0.493743943655287 no 1657 0.483643431081338 531 746691 SGTC_712 r015-0009 80.6 µM 0.0409677987162926 0.493762740240676 no 1658 0.483660783600876 522 6813872 YLR060W FRS1 SGTC_130 0136-0219 337.655 µM 0.0398573010484312 0.49424223452478 no 1659 0.484103446429766 533 234244 SGTC_2976 9009005 19.48 µM 0.0386706447082051 0.494754622024194 no 1660 0.484576489012571 536 2993148 SGTC_3235 9132602 49.47 µM 0.0371829294552135 0.495397016170096 no 1661 0.485169574760619 520 4912240 SGTC_1822 st052468 42 µM 0.0371109062966248 0.495428116023348 no 1662 0.485198288026282 533 2873678 SGTC_3332 9141069 11.198 µM 0.0363463562538296 0.495758253097158 no 1663 0.485503093696807 535 17332883 SGTC_1695 st026914 34.495 µM 0.0361351398409768 0.495849458071951 no 1664 0.485587301536947 507 3289191 SGTC_3258 9138477 49.47 µM 0.0359308218535961 0.495937684456681 no 1665 0.485668759721785 533 4970355 SGTC_1725 st036284 20.55 µM 0.033279648671512 0.497082501856337 no 1666 0.486725791388385 499 707914 SGTC_2446 5162541 200 µM 0.0318984454260241 0.497678936799492 no 1667 0.487276519190296 534 1549321 SGTC_1394 3474-0001 65.7 µM 0.031612367608329 0.497802472393642 no 1668 0.487390590197434 522 5017666 YIL048W NEO1 SGTC_1830 st055982 50.3 µM 0.0316087374284972 0.497804039997941 no 1669 0.487392037706279 529 455313 An antimicrobial agent. SGTC_1699 st031318 29.054 µM 0.0313346286076446 0.497922407278662 no 1670 0.487501337161858 539 5340658 SGTC_1989 st071868 50.2 µM 0.0301002149498332 0.49845546114913 no 1671 0.487993564652353 536 16414057 SGTC_2778 tioconazole 65.09 nM 0.0300973190638896 0.498456711676182 no 1672 0.487994719420504 531 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_160 3453-0671 289.699 µM 0.0299729144400722 0.498510433194043 no 1673 0.488044327303903 526 5322268 SGTC_628 1636-0253 16 µM 0.0299090129336264 0.498538027724926 no 1674 0.488069808892412 528 4456143 SGTC_1142 3253-1408 9.78 µM 0.02938132617393 0.498765898485755 no 1675 0.488280232964771 527 256655 SGTC_1534 6-azauridine 81.6 µM 0.0283943058781486 0.499192124085389 no 1676 0.488673832811435 535 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_294 k038-0071 157 µM 0.0272958393628586 0.499666476639289 no 1677 0.489111887670557 525 24152826 SGTC_2720 fluspirilene 36.88 µM 0.0270255645956679 0.499783189922823 no 1678 0.489219671938426 524 3396 An atypical antipsychotic. SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.0260214238484292 0.499783189922823 no 1679 0.489620125237783 533 16725076 SGTC_2456 5770359 74.46 µM 0.0256853807847437 0.499638075790582 no 1680 0.489754142227436 535 3118787 SGTC_857 0438-0306 1.35 µM 0.0250158881474284 0.499348967639643 no 1681 0.490021145332712 538 4686136 SGTC_2889 9059656 51.95 µM 0.0247964747328848 0.499254218036453 no 1682 0.490108651475463 536 3949838 SGTC_1531 st059297 52.4 µM 0.0247282746606437 0.499224767111721 no 1683 0.490135851027477 539 7566702 SGTC_851 0394-0702 453 µM 0.0245395085632973 0.499143252028143 no 1684 0.490211134959016 531 762646 SGTC_644 1498-1197 63.3 µM 0.0242854489294574 0.499033541217774 no 1685 0.490312459890661 532 6741615 SGTC_3015 9080845 49.47 µM 0.0238100128330468 0.498828233404435 no 1686 0.49050207661439 541 5296973 SGTC_2512 diallyl trisulfide 49.23 µM 0.0224726295119001 0.498250712319508 no 1687 0.491035472485158 535 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2771 fluoxetine 41.05 µM 0.0222467837105853 0.498153185850824 no 1688 0.491125549403878 536 3386 A selective serotonin reuptake inhibitor. SGTC_898 1000-0849 28.3 µM 0.0211887787097171 0.497696311569557 no 1689 0.491547532783422 539 6751807 SGTC_1941 st076221 61.8 µM 0.0211214311967127 0.497667229244753 no 1690 0.491574394542326 530 2828568 SGTC_1726 st035556 14.5795 µM 0.0208532381657407 0.497551416973386 no 1691 0.491681364520337 505 5919439 SGTC_1817 st052116 64.4 µM 0.0188762971875163 0.496697732799887 no 1692 0.492469894138236 533 4361398 SGTC_1135 dihydrocapsaicin 536.708 nM 0.0185597717194648 0.4965610518316 no 1693 0.49259614741045 536 107982 A Capsaicinoid. SGTC_2290 7904846 200 µM 0.0173681627140494 0.496046498971982 no 1694 0.493071453898432 532 2962154 SGTC_2166 5933061 31.504 µM 0.0172725551514571 0.49600521460906 no 1695 0.493109590076705 526 2877375 SGTC_669 0108-0021 26.2 µM 0.0155879750256844 0.495277802404344 no 1696 0.493781549529095 534 17201 SGTC_563 tetrahydrosecaminediol 614 µM 0.0148869598802765 0.494975104180011 no 1697 0.494061181639641 535 334274 A psychoactive constituent of the cannabis plant. SGTC_1837 st055472 66.5 µM 0.0147000885341368 0.494894413644742 no 1698 0.49413572436328 532 676091 SGTC_393 acivicin 6.25 µM 0.0132816103496657 0.49428192569824 no 1699 0.494701559855336 541 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_349 k015-0014 24 µM 0.0119324344309154 0.493699374421851 no 1700 0.495239760360518 541 2196908 SGTC_174 3553-0389 74.3 µM 0.0117534773798581 0.493622104785116 no 1701 0.495311148887969 537 738071 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.0112236087274348 0.493393320811853 no 1702 0.49552252194434 541 6728940 SGTC_2867 9039098 71.43 µM 0.0110848369604425 0.493333403005 no 1703 0.495577880425608 530 6463460 SGTC_643 k048-0106 28.4 µM 0.00961755629256486 0.492699881303397 no 1704 0.4961632093097 544 6763920 SGTC_2696 st077691 74.316 µM 0.00872572476899616 0.492314827792168 no 1705 0.496518983635653 542 757133 SGTC_414 piperonyl butoxide 100 µM 0.00860231616445714 0.492261545956458 no 1706 0.496568214697932 540 5794 A potent inhibitor of cytochrome P450. SGTC_2381 9035592 200 µM 0.00852395624993799 0.492227714026583 no 1707 0.49659947463479 534 4749657 SGTC_1230 0170-0365 3.77 µM 0.00833954989482373 0.492148096717246 no 1708 0.496673039511441 544 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_317 4495-0002 170 µM 0.00801372327380951 0.492007422077857 no 1709 0.496803021180879 543 15991618 SGTC_1092 toremifene 6.32 µM 0.00666140347893745 0.491423572995465 no 1710 0.497342504159538 546 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2160 5660466 132.927 µM 0.00647288033227435 0.491342181647277 no 1711 0.497417712391681 544 2859134 SGTC_3117 9124945 49.47 µM 0.00621345373266476 0.491230179647325 no 1712 0.497521206548532 547 17592065 SGTC_138 0850-0259 40.9225 µM 0.00574364262781859 0.491027350310333 no 1713 0.497708630710749 546 6813004 SGTC_1889 st059080 5.18 µM 0.00513044239339479 0.490762619757652 no 1714 0.497953258590978 540 176925 Isolated from Daphnopsis sellowiana. SGTC_1827 berberine 7.24 µM 0.00465809115703396 0.490558699244708 no 1715 0.498141697211682 542 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_537 1334-0398 209 µM 0.00320111160377433 0.489929716949056 no 1716 0.498722943417996 541 5846986 SGTC_2187 6125751 200 µM 0.00265113807865629 0.48969229821043 no 1717 0.498942350168196 544 874498 SGTC_3186 9110464 49.47 µM 0.00197175329607081 0.489399018820512 no 1718 0.499213384753378 546 17018021 SGTC_2751 anetholtrithion 17.25 µM 0.0017632165525138 0.489308998033469 no 1719 0.49929657873218 548 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1650 st011916 45.8 µM 0.00154574119274152 0.48921511921997 no 1720 0.499383338729224 548 242528 SGTC_373 0844-0104 25.9 µM 0.00056929066763605 0.48879361676045 no 1721 0.49977288589511 547 5375804 SGTC_767 0929-0023 86 µM 6.11100430270088e-05 0.488574256361263 no 1722 0.499975620620095 547 1204563 SGTC_1587 estradiol valerate 56.1 µM 3.29777752278687e-05 0.488562112933911 no 1723 0.49998684377115 548 13791 A steroid. SGTC_110 0850-0284 111.64 µM -0.00015304178581118 0.488481816972022 no 1724 0.49993894516121 549 3906265 SGTC_1259 0671-0132 43 µM -0.0007840266778514 0.488209453742822 no 1725 0.499687218641287 549 X1259 SGTC_1674 st016616 23.6 µM -0.00218596989765691 0.487604327927032 no 1726 0.49912792487867 550 625830 SGTC_1704 st028805 70.8 µM -0.0022132240158428 0.487592564411819 no 1727 0.499117052084913 550 2876101 SGTC_2191 5911152 200 µM -0.00328811198753973 0.487128626321488 no 1728 0.498688235469206 553 2875902 SGTC_1867 st057372 64 µM -0.00365207477642606 0.486971538330733 no 1729 0.498543036199242 550 688837 SGTC_1985 st071382 65.5 µM -0.00393207648079586 0.486850689699415 no 1730 0.498431332484293 551 6123237 SGTC_2413 inermin 26.06 µM -0.00422683235446127 0.48672347447892 no 1731 0.498313742882781 555 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2728 chlorpromazine 9.18 µM -0.00480129813266321 0.486475541700138 no 1732 0.498084566533314 551 2726 A thorazine and dopamine antagonist. SGTC_1724 st037281 8.293 µM -0.00507205127853693 0.486358689583764 no 1733 0.497976552972398 550 574124 YDL195W SEC31 SGTC_1310 1188-0297 994 nM -0.00563932184400832 0.486113869770186 no 1734 0.497750248008057 551 1588352 SGTC_961 1252-1571 372 µM -0.00572876507863467 0.486075268778448 no 1735 0.4977145658965 550 6813498 SGTC_25 0118-0223 35.662 µM -0.0071989200331498 0.485440813379339 no 1736 0.49712807123159 551 5333628 SGTC_448 monastrol 171 µM -0.00778557150215807 0.485187650133597 no 1737 0.49689403772878 546 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2612 dictamnine 15.46 µM -0.00791977043730983 0.485129738835812 no 1738 0.496840501750262 551 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1406 3909-7906 11.9 µM -0.00876349551486309 0.484765650675342 no 1739 0.496503915864279 553 X1406 SGTC_2979 9012552 45.46 µM -0.00946223600319518 0.484464136538846 no 1740 0.496225170320483 555 17100905 SGTC_2896 9052656 71.43 µM -0.00961875372568121 0.484396598647297 no 1741 0.496162731625097 554 6469436 SGTC_922 1866-0035 480 µM -0.00968300469738539 0.484368874279584 no 1742 0.4961371003896 557 3156169 SGTC_2283 7944793 200 µM -0.00988629047874377 0.484281156731039 no 1743 0.496056004978654 552 2970533 SGTC_1254 0550-0035 264 µM -0.00990367929099232 0.484273653516574 no 1744 0.496049068185844 553 15121435 SGTC_1730 st033808 45.1 µM -0.0122685268083032 0.483253282692594 no 1745 0.495105688717542 554 1045166 SGTC_492 tmb-8 126 µM -0.0124322365324316 0.483182650143309 no 1746 0.495040382967743 557 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_1101 ebselen 5.29 µM -0.0126788276838538 0.483076259404819 no 1747 0.494942015085447 557 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2947 9072639 7.68 µM -0.01304257647811 0.482919323685004 no 1748 0.494796912313099 556 16488146 SGTC_722 3534-0461 190 µM -0.0142810636402587 0.482385010978309 no 1749 0.494302873559119 554 658262 SGTC_799 1310-0557 151 µM -0.0146326418877241 0.482233337515532 no 1750 0.494162628788443 563 5354492 SGTC_1270 0831-1170 17.3 µM -0.015889398073451 0.481691184756949 no 1751 0.493661314023974 553 6764716 SGTC_685 1278-0033 54.9 µM -0.0166206151757125 0.481375760116133 no 1752 0.493369639148704 555 3590572 SGTC_3192 9110362 49.47 µM -0.0167107012813068 0.481336900534669 no 1753 0.493333704982917 554 16649480 SGTC_976 1348-1067 47.6 µM -0.0168428656561751 0.481279890373804 no 1754 0.493280986445471 555 5310671 YGL099W LSG1 SGTC_2919 7978188 46.38 µM -0.0168701753784272 0.481268110154229 no 1755 0.493270092990355 553 2980291 SGTC_2605 digitonin 300 nM -0.0169695521657465 0.481225243493337 no 1756 0.49323045306272 556 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_995 3931-2021 34.6 µM -0.017535936834774 0.480980934868885 no 1757 0.493004531900325 559 730143 SGTC_2565 isoliquiritigenin 100 µM -0.0181625324998567 0.480710662706788 no 1758 0.492754596218218 554 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1897 st060201 15 µM -0.0188375434681728 0.480419517291312 no 1759 0.4924853518869 559 611878 SGTC_2128 5255449 168.493 µM -0.0194164868359084 0.480169816023501 no 1760 0.492254429147341 558 736008 SGTC_2999 9069765 71.4286 µM -0.0203990165096057 0.479746063755838 no 1761 0.491862534199833 556 2097066 SGTC_1001 4048-4355 44.4 µM -0.0222036007084455 0.478967830039537 no 1762 0.491142772674904 562 21824233 SGTC_2116 5511452 16.8835 µM -0.0227479923225672 0.478733074716783 no 1763 0.490925646694377 565 870744 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.0232976032232718 0.478496076191181 no 1764 0.490706441773472 558 390807 SGTC_1702 st027038 51 µM -0.0233641822889422 0.478467367048926 no 1765 0.490679887797245 561 5521182 SGTC_734 2023-0417 80 µM -0.0235704783564794 0.478378412122739 no 1766 0.490597610232658 559 3935732 SGTC_2844 9010103 25.97 µM -0.0241316449304033 0.478136442390535 no 1767 0.490373800831541 560 2480525 SGTC_2721 ifenprodil 61.44 µM -0.0267740641867488 0.476997165935293 no 1768 0.489319969790489 562 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1510 1123-0200 71.5 µM -0.0284030253953102 0.47629493398646 no 1769 0.488670355629803 566 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_807 1315-0151 48 µM -0.0284668180474932 0.476267434975829 no 1770 0.488644916330158 556 4011080 SGTC_630 4356-0227 183 µM -0.0289162703496046 0.476073693402507 no 1771 0.48846568459272 559 779312 SGTC_951 1171-0579 82.7 µM -0.0307282005535725 0.475292697925544 no 1772 0.487743150493996 565 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_3051 9093778 49.47 µM -0.0312035254111591 0.475087834456329 no 1773 0.48755361420667 560 17217378 SGTC_2855 9016525 58.44 µM -0.0324387184423853 0.474555501203363 no 1774 0.487061092936016 564 43811474 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.0326249586702048 0.47447524085141 no 1775 0.486986833140666 558 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2224 6650123 117.647 µM -0.0331255232034193 0.474259527370655 no 1776 0.486787244671287 559 2908370 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0331374257896695 0.474254398156966 no 1777 0.486782498831841 565 165506 SGTC_6 0844-0013 19.835 µM -0.0338749625671051 0.47393657779734 no 1778 0.486488429351735 565 1584900 SGTC_1178 0988-0033 191 µM -0.0338816183952896 0.473933709733951 no 1779 0.486485775583814 565 5392207 SGTC_101 0490-5701 117.494 µM -0.0340216261370187 0.473873379301498 no 1780 0.486429952759212 568 4661669 SGTC_407 eburnamonine 100 µM -0.0347541084345519 0.473557756742248 no 1781 0.486137907334232 571 3195 SGTC_738 1315-0003 72.4 µM -0.0350932941802837 0.47341160909637 no 1782 0.486002674294647 571 6251474 SGTC_2161 5662504 8.5105 µM -0.0353666014349189 0.473293849639888 no 1783 0.4858937081182 558 2859334 SGTC_1784 st039334 36.3 µM -0.0377855439579075 0.47225170668013 no 1784 0.484929335196106 568 3496984 SGTC_3067 9117431 49.47 µM -0.0389058161092525 0.471769128400671 no 1785 0.484482739748442 565 17150885 SGTC_2173 5763948 167 µM -0.0400215074489991 0.471288564580406 no 1786 0.484037989781548 560 2867177 SGTC_2536 dehydroabietamide 32.04 µM -0.0400894040107666 0.471259320709523 no 1787 0.48401092469323 573 3983547 SGTC_1129 3453-1384 223 µM -0.0403020928268669 0.471167714066125 no 1788 0.483926142650848 602 1084452 SGTC_1480 1070-0044 41.2 µM -0.040994479281871 0.470869508699723 no 1789 0.483650148529508 567 3124987 SGTC_1860 st056228 74.6 µM -0.0410379574675983 0.470850783532527 no 1790 0.483632817827062 562 688679 SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.0417490879060892 0.47054452334445 no 1791 0.483349360779302 562 5106787 A p450 inhibitor. SGTC_1466 k213-0079 57.5 µM -0.0439277347795672 0.469606361935904 no 1792 0.482481003738448 566 3657981 SGTC_3304 9125678 46.087 µM -0.0444674166954737 0.469373991839265 no 1793 0.482265911992334 575 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1157 4092-0394 27.6 µM -0.0455333663286209 0.468915058101926 no 1794 0.48184108999258 576 3659885 SGTC_1044 1222-0021 1.78 µM -0.0459623092389186 0.468730392728353 no 1795 0.481670145506557 572 4306703 SGTC_333 3486-0131 40.1 µM -0.0461478437934543 0.468650519826881 no 1796 0.481596206385007 566 6744690 SGTC_1165 k072-0275 30.3 µM -0.0479412438240572 0.467878523971329 no 1797 0.480881534672356 569 6153523 YGL055W OLE1 SGTC_3042 9091578 49.47 µM -0.0480049942626792 0.467851083847944 no 1798 0.480856131175884 562 25236497 SGTC_1525 8-methoxypsoralen 92.5 µM -0.0481234795925554 0.467800084572241 no 1799 0.480808916936207 570 4114 Related to psoralen; DNA damaging agent. SGTC_199 4063-0024 41.6 µM -0.0493358097994719 0.467278295530404 no 1800 0.480325841079744 564 306215 SGTC_325 2810-4341 181 µM -0.0506960250807202 0.466692923465367 no 1801 0.479783872052156 570 774970 SGTC_3231 9132313 49.47 µM -0.0510374757981581 0.466545990552671 no 1802 0.479647829039487 595 4905967 SGTC_2147 5545932 89.7195 µM -0.0512468515495876 0.466455894331185 no 1803 0.47956440936422 578 797404 SGTC_100 0086-0128 49.5915 µM -0.0523756673326358 0.465970184733977 no 1804 0.479114681077491 589 93297 SGTC_1655 st012546 55.1 µM -0.0526233487191836 0.465863618540601 no 1805 0.479016006577569 572 720985 YLR208W SEC13 SGTC_2282 7944268 200 µM -0.0541758426218772 0.465195706094252 no 1806 0.478397533603696 589 2970414 SGTC_283 0987-0079 11.7 µM -0.0546186115594854 0.465005236349785 no 1807 0.478221155505155 570 411556 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.0550965908207384 0.46479962887651 no 1808 0.478030756076013 577 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_523 1934-0222 13.7 µM -0.0564977489151182 0.464196961320014 no 1809 0.477472644384088 575 1361595 SGTC_1575 cyproterone acetate 48 µM -0.0566118291075306 0.464147896628064 no 1810 0.477427205696691 576 9880 An androgen receptor antagonist and liver toxin. SGTC_2497 7-hydroxyflavone 100 µM -0.0570116638643276 0.463975936209912 no 1811 0.477267951917297 601 5281894 SGTC_1304 1165-0502 251 µM -0.0570629500599434 0.463953879595114 no 1812 0.477247524939583 569 767425 SGTC_887 0885-0007 9.62 µM -0.0573705587602707 0.463821588884715 no 1813 0.477125007534016 571 5719458 SGTC_2239 6685329 187.64 µM -0.0582103394465268 0.463460451811987 no 1814 0.476790542500853 586 805680 SGTC_796 1234-0020 70.7 µM -0.0588961480451361 0.463165550810488 no 1815 0.476517413071205 565 46495034 SGTC_3180 9109287 49.47 µM -0.0590974255451261 0.463079004350568 no 1816 0.476437254588601 567 18891271 SGTC_1312 1218-2183 165 µM -0.0591959110677241 0.463036657614222 no 1817 0.476398033214304 565 6744073 SGTC_908 3448-7491 47.7 µM -0.0593205200510105 0.462983078930787 no 1818 0.476348408628182 573 1203031 SGTC_3101 9120531 49.47 µM -0.0594310075259157 0.462935572697297 no 1819 0.476304408132873 581 24824904 SGTC_645 0845-0943 5.41 µM -0.0594762449192027 0.462916122154853 no 1820 0.47628639289173 581 1885106 SGTC_529 4076-0302 30.3 µM -0.0602579634906991 0.462580023766639 no 1821 0.475975090674746 596 5816522 SGTC_1003 4049-0218 100 µM -0.06035615817483 0.46253780703573 no 1822 0.475935987835615 568 295161 SGTC_233 rapamycin 362 pM -0.0606160566532615 0.462426071210877 no 1823 0.475832492839317 573 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_2071 5230951 39.92 µM -0.061158053098752 0.462193065082831 no 1824 0.47561666797161 571 1799272 SGTC_748 act1.228 77.9 µM -0.0633589113524163 0.46124704271893 no 1825 0.474740352735284 585 4421505 YNR035C ARC35 SGTC_969 1313-0238 134 µM -0.0635109798331216 0.461181685263206 no 1826 0.47467980812702 576 5212874 SGTC_667 1498-1044 59 µM -0.063730890153013 0.461087171943536 no 1827 0.474592253975234 577 6739982 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.0660424223498303 0.460093852866596 no 1828 0.473672025503252 576 688667 SGTC_2365 9042475 200 µM -0.0660876614336616 0.46007441504565 no 1829 0.473654017062627 572 6464479 SGTC_3071 9117417 49.47 µM -0.0677503760239092 0.459360065116628 no 1830 0.472992173567611 586 45595590 YGL055W OLE1 SGTC_61 0978-8327 98.565 µM -0.0677600336391268 0.459355916308819 no 1831 0.472988329570157 607 6150059 YHR072W ERG7 SGTC_1067 clotrimazole 1.36 µM -0.0686931971654406 0.458955060220643 no 1832 0.472616916644808 574 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_230 MPP+ 141.667 µM -0.069190471001998 0.458741464898221 no 1833 0.472419003984929 598 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_159 3970-0959 50 µM -0.0698231892464335 0.458469709015239 no 1834 0.472167194934963 583 6615653 SGTC_3354 9151612 71.43 µM -0.0704039773347899 0.458220274495626 no 1835 0.471936062825427 579 27261949 SGTC_1195 1502-0147 41.1 µM -0.0729324519283065 0.45713454844136 no 1836 0.4709299348973 582 817940 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.0731229322310219 0.45705276912523 no 1837 0.470854146611881 588 1377 SGTC_980 1473-0395 201 µM -0.0733147025836618 0.456970437786425 no 1838 0.470777846107878 573 768876 SGTC_1010 4112-3296 15.2 µM -0.0741276273356694 0.456621451401294 no 1839 0.470454416147848 579 704384 SGTC_2103 5378138 10 µM -0.0757079959307074 0.45594309944119 no 1840 0.469825707210508 579 244142 SGTC_234 nsc-17383 10.7 µM -0.0761261554401323 0.455763631498368 no 1841 0.469659365741195 581 408974 SGTC_849 0386-0493 241 µM -0.0762404225803626 0.455714591282428 no 1842 0.469613911844087 584 726119 SGTC_1665 st014639 11.4 µM -0.076510482035959 0.455598692106072 no 1843 0.469506487481123 579 981133 YIL048W NEO1 SGTC_2679 rapamycin 1 nM -0.0772264321837603 0.455291452032961 no 1844 0.469221707295469 587 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2201 6605497 169.863 µM -0.0776725317922083 0.455100028084168 no 1845 0.469044272265807 588 670741 SGTC_2816 7982706 58.44 µM -0.078822725031902 0.45460652164206 no 1846 0.468586814160194 588 2981853 SGTC_197 4544-0043 41.561 µM -0.0805201994890391 0.45387832477559 no 1847 0.467911765762543 585 896523 SGTC_3222 9128301 49.47 µM -0.0815943847895392 0.453417591665808 no 1848 0.467484633347787 574 4911358 SGTC_22 0964-0034 14.468 µM -0.0820663882239652 0.453215162575837 no 1849 0.467296960624286 576 138402 SGTC_2942 9052777 62.25 µM -0.0821912849658768 0.453161599883393 no 1850 0.467247301794044 579 6469503 SGTC_3141 9094609 49.47 µM -0.0825251466730868 0.45301842553914 no 1851 0.467114561189601 607 25236309 YDL196W YDL196W SGTC_1190 1486-1332 13 µM -0.0836297431100811 0.45254477042893 no 1852 0.466675409091832 589 4150046 SGTC_3009 9080819 71.4286 µM -0.0838310249666431 0.452458467264524 no 1853 0.466595390238484 597 17027216 SGTC_816 0325-0417 81.3 µM -0.0838740719162705 0.452440010413124 no 1854 0.466578277258933 586 68101 SGTC_3115 9123671 49.47 µM -0.083953055125022 0.452406145764105 no 1855 0.46654687826017 576 3286988 SGTC_3047 9092122 49.47 µM -0.0843277559761225 0.452245494657473 no 1856 0.466397922457692 596 17173831 SGTC_1197 1601-0112 267 µM -0.0850916355241286 0.45191800938423 no 1857 0.466094270037259 590 7350313 SGTC_2001 4023502 57.655 µM -0.0855953579797141 0.451702074785075 no 1858 0.465894044356713 585 108941 YCR052W RSC6 SGTC_2242 6630449 61.2675 µM -0.085665617640229 0.451671957167284 no 1859 0.465866117383843 611 691249 YDR170C SEC7 SGTC_2486 5283202 22.39 µM -0.0858045528969981 0.451612401778226 no 1860 0.465810893570601 593 1377751 SGTC_2528 xanthyletin 44.79 µM -0.0865502065991465 0.451292791711185 no 1861 0.465514523337691 585 65188 An natural product with antifungal activity of unknown mechanism. SGTC_3127 9126946 49.47 µM -0.086922916611349 0.451133048580273 no 1862 0.4653663918195 588 27243249 SGTC_1381 2324-0066 62.1 µM -0.087095262925512 0.451059183800139 no 1863 0.465297895358364 599 10885928 SGTC_1638 st008370 60.6 µM -0.0872599357130103 0.450988609349803 no 1864 0.465232449585952 586 24207134 SGTC_3291 9121177 71.43 µM -0.0886801782727822 0.450379995068102 no 1865 0.464668042953814 594 17015612 SGTC_1367 1812-0510 76.9 µM -0.089692148198036 0.44994640830451 no 1866 0.464265927812058 589 1142582 YDR527W RBA50 SGTC_565 1418-0001 44.5 µM -0.0898840601219837 0.449864188799918 no 1867 0.464189674027273 611 2862145 SGTC_1311 1190-0148 100 µM -0.0900269929939582 0.449802954451544 no 1868 0.464132882306114 594 1961333 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.0905129755555702 0.449594761990744 no 1869 0.463939791637567 579 5355888 SGTC_2382 9035899 200 µM -0.0907375631225613 0.449498554501731 no 1870 0.463850561336539 596 6462679 SGTC_1755 st041960 45.185 µM -0.0909626872581984 0.449402120139876 no 1871 0.463761119677708 583 2257073 SGTC_248 streptozotocin 5.23457 mM -0.0915975587628676 0.449130182170112 no 1872 0.463508895561255 603 5300 DNA alkylating agent. SGTC_794 k038-0031 316 µM -0.0916254808842641 0.449118222683365 no 1873 0.463497802892831 584 6624242 SGTC_1849 st056239 19.2 µM -0.0922218196520763 0.448862812399884 no 1874 0.463260901170525 592 5393181 SGTC_1349 flufenamic acid 69 µM -0.0932048715042472 0.448441820254577 no 1875 0.462870402169021 601 3371 A non-steroidal anti-inflammatory. SGTC_510 ag-490 170 µM -0.0940574201960317 0.448076763100828 no 1876 0.462531772067725 587 5328779 SGTC_1922 5578187 25 µM -0.0942266542223789 0.448004303144191 no 1877 0.462464555979141 584 1350412 SGTC_818 4072-2707 53.5 µM -0.094414877324263 0.447923714782584 no 1878 0.462389799100253 583 882871 SGTC_711 k292-0785 179 µM -0.0958054856649035 0.447328387906682 no 1879 0.461837530236807 598 4146315 SGTC_2887 9044784 58.44 µM -0.0959185475834578 0.447279990691553 no 1880 0.461792631829433 593 6465546 SGTC_936 3005-4620 401 µM -0.0963589010297416 0.447091500756249 no 1881 0.461617766204212 581 777207 SGTC_1992 st073643 23.3 µM -0.0964088386860391 0.447070126076865 no 1882 0.461597936284476 582 3161292 SGTC_1249 0481-0015 10.2 µM -0.0967884298948111 0.446907655713249 no 1883 0.46144720619958 588 4227577 SGTC_867 0518-0118 155 µM -0.0983725414356267 0.446229730235414 no 1884 0.460818238832501 597 6848158 SGTC_2543 pimpinellin 60.67 µM -0.0996145730635088 0.445698308726252 no 1885 0.46032516187197 595 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_819 1013-0258 27.7 µM -0.101048881152594 0.445084740324354 no 1886 0.459755828588422 613 5753198 SGTC_3241 9133421 49.47 µM -0.1011280553374 0.445050875004078 no 1887 0.459724403633387 594 17018221 SGTC_300 r073-0011 5.04 µM -0.102182660529626 0.44459982511988 no 1888 0.459305845300635 589 2735780 SGTC_1262 0737-0114 49.6 µM -0.102847023172379 0.444315717003297 no 1889 0.459042192008855 593 765919 SGTC_2056 5235370 200 µM -0.104710215657723 0.443519094244199 no 1890 0.458302877802637 606 5511916 SGTC_1019 4262-0212 3.4 µM -0.10537989537584 0.443232822940456 no 1891 0.458037184198189 589 4677213 SGTC_2376 9072922 81.32 µM -0.106000781700658 0.442967436054551 no 1892 0.457790865987248 634 17087968 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.106066951323631 0.442939154525236 no 1893 0.457764616108594 599 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1380 2291-0730 164 µM -0.107029483853397 0.442527791867527 no 1894 0.457382794681853 600 2999191 SGTC_2870 9038528 12.99 µM -0.107660744445955 0.442258040275709 no 1895 0.457132404926727 632 6463316 SGTC_304 1310-0298 97 µM -0.111579844294689 0.440583926176795 no 1896 0.45557827706595 595 1550234 SGTC_2200 6600604 21.907 µM -0.111699338661379 0.440532898529317 no 1897 0.455530901860665 623 2904777 SGTC_88 0180-0332 8.668 µM -0.112521792097367 0.440181713291392 no 1898 0.455204845934995 587 3101745 SGTC_3285 9112818 20.8695 µM -0.11353463475346 0.439749297087775 no 1899 0.4548033530133 594 17017947 YPR165W RHO1 SGTC_2616 abietic acid 100 µM -0.113683030049933 0.439685948225971 no 1900 0.454744532678926 590 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_881 0833-0569 170 µM -0.114494273755195 0.439339661587774 no 1901 0.454422992715765 593 5418700 SGTC_1136 pergolide 1.05886 µM -0.114562062599191 0.439310727410455 no 1902 0.454396125662386 597 47811 A dopamine receptor agonist. SGTC_502 l-744,832 89.3 µM -0.115159109540839 0.439055905073602 no 1903 0.454159504423505 625 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_297 0986-0032 24 µM -0.116471961469426 0.438495662898614 no 1904 0.453639253171716 608 2847425 SGTC_646 4092-0839 27.3 µM -0.117268705010878 0.438155723152955 no 1905 0.453323561836017 596 877796 SGTC_1039 k821-0043 94 µM -0.117511150143631 0.438052290207222 no 1906 0.453227504362488 584 15992768 SGTC_1302 1159-0335 255 µM -0.118319748560367 0.43770735323797 no 1907 0.45290715511069 616 649284 SGTC_2825 7998094 58.44 µM -0.11852412761151 0.437620175427678 no 1908 0.45282618938294 617 2987815 SGTC_1501 4491-0275 38.4 µM -0.11916575201712 0.437346510463547 no 1909 0.452572019598974 599 5104718 SGTC_2691 st077356 60.2 µM -0.120118872651571 0.436940041825197 no 1910 0.452194491210328 615 2839272 SGTC_515 4092-1064 102 µM -0.120204346977593 0.436903593617103 no 1911 0.45216063717817 658 717353 SGTC_1615 st002656 86.5 µM -0.121061242984936 0.43653822320525 no 1912 0.451821263475738 588 1584458 SGTC_2197 6588183 93.1375 µM -0.121164876820217 0.436494038616234 no 1913 0.45178022167196 606 884136 SGTC_1171 0368-0077 21.4 µM -0.122264352286289 0.436025322935628 no 1914 0.451344831450627 590 3239779 SGTC_2079 5212404 121 µM -0.12230666939399 0.43600728458622 no 1915 0.451328075121666 606 758462 SGTC_402 epigallocatechin gallate 10 µM -0.122607382760017 0.43587910450176 no 1916 0.451209003980408 620 65064 An antioxidant. SGTC_2604 4'-hydroxychalcone 11.32 µM -0.123117720941118 0.435661586555134 no 1917 0.451006939378248 617 5282362 SGTC_1460 k062-0059 9.15 µM -0.123337743327715 0.435567813921043 no 1918 0.450919827066455 585 1373085 SGTC_380 3970-0968 6 µM -0.123835793680317 0.435355560303819 no 1919 0.450722645335926 598 2891601 SGTC_472 calcifediol 10 µM -0.124714564914715 0.434981100706916 no 1920 0.450374763147944 591 5283731 A vitamin D metabolite. SGTC_1821 st053465 65.6 µM -0.125165201619009 0.434789099221475 no 1921 0.450196382818621 621 675086 SGTC_1172 0370-0043 85 µM -0.125395901745591 0.434690811429971 no 1922 0.450105066220365 620 376585 SGTC_493 zm226600 134 µM -0.126425032607414 0.43425240838116 no 1923 0.449697743986322 632 5240098 A potassium channel opener. YCR052W RSC6 SGTC_3292 9120825 59.784 µM -0.126832013855 0.434079059296682 no 1924 0.449536678476068 601 24824900 SGTC_2521 angolensin 13.4 µM -0.126985265496227 0.43401378676756 no 1925 0.449476030282607 589 821428 A flavenoid. SGTC_2575 plumbagin 510 nM -0.127456735731441 0.433812990715284 no 1926 0.449289456861886 613 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2853 9015042 58.44 µM -0.127862885734546 0.43364002780927 no 1927 0.449128741396852 588 6457456 SGTC_1959 st077091 55.8 µM -0.129061159136375 0.433129805665837 no 1928 0.448654627713988 599 821356 YKL052C ASK1 SGTC_2490 carminic acid 95.39 µM -0.130683651603238 0.432439129750651 no 1929 0.448012782776729 599 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2772 vinpocetine 57.06 µM -0.130894959681219 0.432349193538498 no 1930 0.447929200984711 601 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_893 0958-0369 48.9 µM -0.133762163583048 0.431129212490554 no 1931 0.446795323670651 614 6819948 SGTC_1016 4226-1401 38 µM -0.134967655474019 0.430616477118327 no 1932 0.446318723742559 593 2901613 SGTC_2759 disulfiram 3.38 µM -0.136006039953579 0.430174911744714 no 1933 0.445908253071657 604 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2417 cerulenin 830 nM -0.136247601589388 0.430072201931116 no 1934 0.445812772683192 626 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1719 st032227 49.2 µM -0.137622973449981 0.429487496676507 no 1935 0.445269199053513 599 3125804 SGTC_1080 nisoldipine 24.4 µM -0.138146001510456 0.429265184779739 no 1936 0.445062515167522 625 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2471 5466956 24.79 µM -0.138433655317605 0.429142927735327 no 1937 0.444948849985895 606 724419 SGTC_202 3594-0513 34.79 µM -0.139052464133963 0.428879948057188 no 1938 0.444704345660645 609 708429 SGTC_897 1000-0139 31.4 µM -0.139385543667607 0.428738409890027 no 1939 0.444572747663703 632 6151020 SGTC_579 4491-1009 110 µM -0.142373400325589 0.427469167834781 no 1940 0.443392535900227 609 1271041 SGTC_214 4373-3496 70 µM -0.143768293971182 0.426876872867072 no 1941 0.442841720236074 621 3779166 SGTC_2434 5670830 169.91 µM -0.144339775675685 0.426634259783591 no 1942 0.442616085350885 632 1549830 SGTC_226 1,3-diallylurea 8.28947 mM -0.144582849730197 0.426531075131748 no 1943 0.442520119435827 608 74537 YKL182W FAS1 SGTC_1388 3346-4487 254 µM -0.145189066969701 0.426273758545262 no 1944 0.442280798881638 633 3345614 SGTC_1467 k284-1082 293 µM -0.145525861717097 0.426130815302127 no 1945 0.442147849196079 630 3334705 SGTC_732 3970-1727 52.7 µM -0.146509593338619 0.425713353179769 no 1946 0.441759558624 615 1275699 SGTC_1939 st074455 53.6 µM -0.147701454124641 0.425207679721669 no 1947 0.441289191999906 600 1644229 SGTC_1636 st007707 68.9 µM -0.148517213238299 0.424861646630242 no 1948 0.44096730119918 632 403051 SGTC_2847 9005661 71.43 µM -0.149265954134627 0.424544092630796 no 1949 0.440671889467764 605 2991449 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.149678619612227 0.424369094963925 no 1950 0.440509088603755 607 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2397 5161689 200 µM -0.15001826074161 0.424225075670947 no 1951 0.440375104154491 639 2259942 SGTC_2374 9071832 200 µM -0.150134876380323 0.42417562903976 no 1952 0.440329102223867 599 17381698 SGTC_717 1532-0246 73.2 µM -0.15070698864802 0.423933062892099 no 1953 0.440103430031668 622 9561992 SGTC_369 0957-0393 4.5 µM -0.152701141023172 0.42308780108621 no 1954 0.439316980456341 662 6997992 SGTC_3239 9133757 49.47 µM -0.153000426853254 0.422960973184576 no 1955 0.439198969336934 626 17036923 SGTC_577 r071-0003 38.6 µM -0.153224731989733 0.422865924971059 no 1956 0.439110527327636 605 4568517 YMR134W ERG29 SGTC_1928 4'-methoxychalcone 40.3 µM -0.153258215317457 0.422851736958378 no 1957 0.439097325336958 602 641818 SGTC_50 0929-0078 56.389 µM -0.155469212224563 0.421915085500916 no 1958 0.438225711941395 620 1377751 SGTC_627 1391-0720 175 µM -0.156427045368277 0.421509452441418 no 1959 0.437848210226528 628 997839 SGTC_1828 st055811 49 µM -0.157170875255302 0.421194505112879 no 1960 0.437555090587633 654 5877589 SGTC_3352 9151559 45.5865 µM -0.157643410676753 0.420994453594426 no 1961 0.437368897235095 601 17159339 SGTC_1987 st072290 61.9 µM -0.157982188589992 0.420851041900657 no 1962 0.437235416949729 644 54697379 SGTC_442 cape 100 µM -0.158494568799666 0.420634160726887 no 1963 0.437033550021261 617 5281787 SGTC_2096 5468907 200 µM -0.158675497630991 0.420557582612459 no 1964 0.436962271815159 602 759785 SGTC_1401 3807-4679 7.6 µM -0.15964604912112 0.420146848155721 no 1965 0.436579951106016 599 3291456 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.15994730119415 0.420019376850886 no 1966 0.436461293588382 611 756377 SGTC_1043 0916-0009 19.3 µM -0.160510399158915 0.419781131015206 no 1967 0.43623951524505 609 3101130 SGTC_2131 toluylene red 5.2905 µM -0.160730202357745 0.419688140610861 no 1968 0.436152950327917 607 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1037 k284-1091 78.7 µM -0.160893823272755 0.41961892171312 no 1969 0.436088513619813 615 3334711 SGTC_686 1319-0111 510 µM -0.160986582994267 0.419579681344855 no 1970 0.436051984012096 641 4562600 SGTC_2657 nystatin 74.44 µM -0.161864921707344 0.41920815529476 no 1971 0.435706113453845 623 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2640 pentamidine 10.38 µM -0.162436998256313 0.418966212937413 no 1972 0.435480868657192 637 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2902 5787006 60.46 µM -0.162665897938449 0.418869415364725 no 1973 0.435390749405116 641 591003 SGTC_379 3970-0972 5.9 µM -0.163284131202385 0.418608000161437 no 1974 0.435147363843412 617 2898042 YBL034C STU1 SGTC_1008 4106-0037 6 µM -0.163327098647732 0.418589833040498 no 1975 0.435130449366982 628 2905394 SGTC_841 0251-0215 91.2 µM -0.163740545456381 0.418415031941972 no 1976 0.434967698814834 644 3888614 SGTC_2087 5276107 200 µM -0.165529706021104 0.417658779218102 no 1977 0.434263535151616 607 144405 SGTC_3171 9103192 49.47 µM -0.166212176552781 0.417370388688127 no 1978 0.43399498861694 606 13018434 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.167520801614728 0.416817529435491 no 1979 0.433480140736721 615 16623 A steroid. SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.167880300497744 0.41666567947911 no 1980 0.433338724044767 601 688803 SGTC_2008 4012253 172 µM -0.16851894828407 0.416395949546447 no 1981 0.433087519129697 623 603940 SGTC_1273 0849-0096 14.1 µM -0.169106635735011 0.416147777250024 no 1982 0.432856382770943 641 5286025 SGTC_2827 7993847 71.43 µM -0.169655270272219 0.415916126628112 no 1983 0.432640626578241 625 2985692 SGTC_1911 st060208 74.3 µM -0.170000884276968 0.415770212602372 no 1984 0.43250472061047 622 688783 SGTC_1614 st002383 48.6 µM -0.171722957700571 0.41504334762062 no 1985 0.431827668141922 634 1947235 SGTC_1609 st001574 46.4 µM -0.172133551401609 0.414870084142359 no 1986 0.431666268108774 634 3960012 SGTC_1515 3460-0031 42.1 µM -0.172905599538508 0.414544337975244 no 1987 0.431362815077283 612 2876596 SGTC_1816 st051957 91.6 µM -0.172938637110801 0.414530399917446 no 1988 0.431349830582905 616 674121 SGTC_2805 7950783 58.44 µM -0.173170712124036 0.414432493973259 no 1989 0.431258622077229 631 1178958 YDL195W SEC31 SGTC_103 0844-0104 51.839 µM -0.174567605884564 0.413843296154392 no 1990 0.430709702218637 625 5375804 SGTC_2941 9056145 11.23 µM -0.175523195681385 0.413440348173779 no 1991 0.430334273087315 642 2119517 SGTC_501 nsc-95397 161 µM -0.175545698425677 0.413430860434078 no 1992 0.430325433037021 624 262093 SGTC_2423 st077119 87.2 µM -0.175610934346077 0.413403355566455 no 1993 0.430299805746039 608 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_3070 9117005 49.47 µM -0.17701984035744 0.412809434393172 no 1994 0.429746402666275 620 8779016 SGTC_2950 9072895 21.46 µM -0.177971054089995 0.412408565123825 no 1995 0.42937285414877 641 17332245 SGTC_3155 9099265 49.47 µM -0.177973384071221 0.412407583313627 no 1996 0.429371939225778 649 25236499 SGTC_1573 oleylamine 1.06 µM -0.178342783446274 0.412251932311611 no 1997 0.429226890505796 647 5356789 An amine of the fatty acid oleic acid. SGTC_2313 7726885 200 µM -0.17891587288167 0.412010481302389 no 1998 0.429001879565996 623 726423 SGTC_2960 9079389 5.97 µM -0.1790358665142 0.411959930433768 no 1999 0.428954769628574 649 16457355 SGTC_1204 4049-0315 18.3 µM -0.180047644017367 0.411533747392429 no 2000 0.4285575824025 631 588402 SGTC_245 methotrexate 289.6 µM -0.180575113400325 0.411311606984365 no 2001 0.42835054568002 612 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_212 3807-4682 38.772 µM -0.180629617535383 0.411288654530699 no 2002 0.428329153414533 619 3125501 YBL034C STU1 SGTC_1919 st067113 52.3 µM -0.180690257671337 0.411263118478068 no 2003 0.428305353084597 638 1268243 SGTC_91 0417-1751 58.384 µM -0.18105416480233 0.411109882137827 no 2004 0.428162530558462 620 6795624 SGTC_1558 st069300 45.6 µM -0.182958176617695 0.410308350304728 no 2005 0.427415417429142 616 24208000 SGTC_483 fpl-64176 144 µM -0.183625419008832 0.410027549731526 no 2006 0.427153660350685 625 3423 SGTC_2718 lomofungin 53.02 µM -0.185016289258585 0.409442367931282 no 2007 0.426608129581327 646 5351222 A RNA synthesis inhibitor. SGTC_875 0709-0210 25.7 µM -0.185338536164082 0.409306817501452 no 2008 0.426481757047238 633 6251364 SGTC_301 4119-0100 24.5 µM -0.186393669417524 0.40886306059652 no 2009 0.426068028257278 650 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1113 artemisinin 1.17947 µM -0.186518938047778 0.408810384171973 no 2010 0.426018914510879 648 2240 An anti-malaria and mitochondrial poison. SGTC_2992 9074591 71.4286 µM -0.187405600819628 0.408437582784764 no 2011 0.425671315791037 617 17741321 SGTC_332 4112-0506 40.9 µM -0.189146906670085 0.407705684249622 no 2012 0.424988839375431 627 2790355 SGTC_3208 9114115 49.47 µM -0.18919305321432 0.407686292492011 no 2013 0.424970756038494 663 650895 SGTC_1062 mesoridazine 14.2 µM -0.190183909420737 0.407269968319681 no 2014 0.424582509715328 622 4078 A neuroleptic. SGTC_3295 9122362 53.5725 µM -0.191092589756464 0.406888263711765 no 2015 0.424226526589987 651 4730473 SGTC_1470 k295-0292 231 µM -0.192257493042357 0.406399058258367 no 2016 0.423770256426559 618 5045612 SGTC_2843 9000894 45.46 µM -0.19297995438557 0.406095731275437 no 2017 0.423487333540286 608 2242070 SGTC_957 1187-1561 14.1 µM -0.194320328828476 0.405533121519933 no 2018 0.422962534454824 643 1538454 SGTC_3232 9132874 49.47 µM -0.194442796735232 0.405481726460985 no 2019 0.422914591187544 667 3784940 SGTC_1158 4092-0494 91.8 µM -0.194712027580744 0.405368746384951 no 2020 0.422809197741484 664 1148199 SGTC_2192 5915882 198.485 µM -0.195492131515222 0.405041427995424 no 2021 0.422503848495041 632 2876149 SGTC_1757 st041620 31.8375 µM -0.196772763611476 0.404504240581286 no 2022 0.422002682941436 643 5289815 SGTC_2487 5918373 44.05 µM -0.197795081026883 0.404075537683797 no 2023 0.421602697457187 625 2876279 SGTC_208 k072-0098 12.366 µM -0.198347204445386 0.403844055787185 no 2024 0.421386710727032 642 5948901 SGTC_1893 st059353 36.1 µM -0.198559932662993 0.403754876863383 no 2025 0.421303499279172 698 3112488 SGTC_650 1328-0195 38 µM -0.198967079626755 0.403584208581087 no 2026 0.421144248178653 640 2780821 SGTC_3233 9132340 49.47 µM -0.198987874317712 0.403575492333663 no 2027 0.421136114907811 682 17682950 SGTC_3160 9100216 49.47 µM -0.199864222250158 0.403208208251286 no 2028 0.420793386178731 632 17191039 SGTC_2744 captopril 92.04 µM -0.199910544529853 0.403188796604335 no 2029 0.420775271781813 626 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2900 5328528 85.29 µM -0.200499986850856 0.402941807885239 no 2030 0.420544784139159 618 795359 SGTC_2229 7354935 190 µM -0.201475934763154 0.402532950380397 no 2031 0.420163222440189 643 318112 SGTC_2918 7977171 22.06 µM -0.201508971178864 0.402519112173934 no 2032 0.420150307661095 629 2236483 SGTC_1292 0kpi-0043 232 µM -0.202118932389468 0.402263635199072 no 2033 0.419911873699278 662 3333905 SGTC_454 lyso-paf C-16 6.67 µM -0.203074378800611 0.401863538681543 no 2034 0.419538448615564 659 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1226 3909-7979 35.4 µM -0.203476821489813 0.401695045154871 no 2035 0.419381180250902 630 6615510 SGTC_3230 9131665 49.47 µM -0.205597155503269 0.400807612372984 no 2036 0.418552799820191 641 15943720 SGTC_1862 st057513 3.81 µM -0.205603397781128 0.400805000517954 no 2037 0.418550361593797 632 5393163 SGTC_1363 1636-0063 10.4 µM -0.205604742256882 0.400804437971361 no 2038 0.418549836443558 630 6072185 SGTC_2607 solasodine 47.35 µM -0.205704950442883 0.400762510108561 no 2039 0.418510695683121 638 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.205973793674699 0.400650029716388 no 2040 0.418405690998066 637 4620898 SGTC_979 1426-2828 121 µM -0.206417801396527 0.400464280898197 no 2041 0.418232283369181 651 747872 SGTC_3081 9117243 49.47 µM -0.20749297516839 0.400014579662546 no 2042 0.417812439152393 668 45595589 SGTC_2849 9019321 12.99 µM -0.208010095516769 0.399798336534326 no 2043 0.417610542340332 623 16489627 SGTC_800 3448-7362 155 µM -0.209103552516614 0.399341189176918 no 2044 0.417183700750392 638 15991913 SGTC_661 1304-0007 33.6 µM -0.209317584316566 0.399251723897979 no 2045 0.417100162757265 641 3117130 SGTC_3034 9090421 49.47 µM -0.209784397833706 0.399056614238258 no 2046 0.41691797541583 641 17173761 SGTC_2018 5133068 143 µM -0.210660342879301 0.398690571806214 no 2047 0.416576160957833 651 785362 SGTC_2754 granisetron 64.02 µM -0.210764130326954 0.398647206707072 no 2048 0.416535664817131 667 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_764 1951-2361 146 µM -0.212215306973435 0.398040998599125 no 2049 0.415969532730773 644 5438930 SGTC_435 c-PAF 6.7 µM -0.2147627997703 0.396977416122958 no 2050 0.414976128801224 647 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_599 1935-0052 86.5 µM -0.216590883574794 0.396214659554675 no 2051 0.41426359547843 645 9557311 SGTC_2447 5741742 33.78 µM -0.218387181913643 0.395465552051746 no 2052 0.413563725937875 638 1776504 SGTC_2139 5578692 56.4705 µM -0.218950768709463 0.395230599762214 no 2053 0.413344199044675 635 650991 YMR113W FOL3 SGTC_2880 9042983 58.44 µM -0.219677581899907 0.39492765666422 no 2054 0.413061132622592 673 6464714 SGTC_3206 9114350 49.47 µM -0.220166248671048 0.394724011099233 no 2055 0.412870840678546 661 17087243 SGTC_2387 9077560 195.08 µM -0.222038992269923 0.393943836181182 no 2056 0.412141764704625 627 5303272 SGTC_266 formosanin C 406 nM -0.222147592400331 0.393898606971598 no 2057 0.412099494969031 658 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1389 3405-0187 19 µM -0.222538291111204 0.393735902672657 no 2058 0.411947434240419 639 799890 SGTC_751 0833-0568 350 µM -0.223065672631682 0.393516307003796 no 2059 0.411742197256904 640 6954252 SGTC_2145 5634607 200 µM -0.224200855566455 0.393043744721786 no 2060 0.411300508885953 666 308662 SGTC_657 3534-0529 86.7 µM -0.225429428264804 0.392532483025803 no 2061 0.410822610155155 664 1049549 SGTC_1444 4112-3581 28 µM -0.22635719744275 0.392146521369794 no 2062 0.410461807730079 643 2877249 SGTC_670 4204-0025 119 µM -0.228516449041208 0.391248661551966 no 2063 0.409622384951946 666 719039 SGTC_491 tetrandrine 80.3 µM -0.230335787252601 0.390492593873755 no 2064 0.408915426951992 663 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_836 0330-0104 1.35 µM -0.23093990060605 0.390241632123594 no 2065 0.408680746127697 633 46494820 SGTC_560 2332-1943 155 µM -0.231237620581303 0.390117969623975 no 2066 0.408565102438389 645 21177716 SGTC_1337 1486-1011 40.3 µM -0.231538559649606 0.389992981325028 no 2067 0.408448216444041 641 X1337 SGTC_1787 fluconazole 80 µM -0.232102599510743 0.389758750649657 no 2068 0.408229162944863 655 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2925 9010536 32.5 µM -0.232598842386307 0.38955270735006 no 2069 0.408036463151387 646 2994177 SGTC_2403 6032726 181.2 µM -0.233192975084149 0.389306060388018 no 2070 0.407805780285531 657 2881040 SGTC_24 0417-1663 219 µM -0.233955272490167 0.38898966721218 no 2071 0.407509851219326 681 4329390 SGTC_3030 9087619 49.47 µM -0.234726841273247 0.388669500881261 no 2072 0.40721037668079 637 25236973 SGTC_952 1185-0122 232 µM -0.23475584174383 0.388657468463774 no 2073 0.407199121576112 639 678600 SGTC_3060 1327-0027 12.5 µM -0.235674865340244 0.388276217089602 no 2074 0.40684248755661 641 16000455 YPR107C YTH1 SGTC_753 1322-0200 289 µM -0.235723529366704 0.388256032110219 no 2075 0.406823605265743 665 5403907 SGTC_3242 9133940 49.47 µM -0.237115371072367 0.387678848698616 no 2076 0.406283643987732 674 17248444 SGTC_292 k038-0015 474 µM -0.237277297188836 0.387611715578513 no 2077 0.406220836733797 671 46368540 SGTC_1243 0416-0003 5.65 µM -0.237655142679875 0.387455077286926 no 2078 0.406074288924789 667 2141977 SGTC_2845 9003024 42.97 µM -0.237684822470401 0.387442774113512 no 2079 0.406062778140998 637 2990173 SGTC_1789 tunicamycin 25 nM -0.240572782707517 0.386246169421086 no 2080 0.404943123479666 675 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1329 1447-1697 50.6 µM -0.240642265536189 0.386217393005486 no 2081 0.404916194712439 645 2840515 SGTC_676 falcarinol 140 µM -0.240885363835048 0.38611671841436 no 2082 0.404821983072438 680 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_2045 5106652 78.05 µM -0.241689753465572 0.385783650266316 no 2083 0.404510284886987 635 673349 SGTC_1868 st057644 42.7 µM -0.243074072780111 0.385210651809195 no 2084 0.403974007937787 647 688665 SGTC_270 tamoxifen 5.46 µM -0.243551271488176 0.385013187374414 no 2085 0.403789185806043 675 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2193 5925765 200 µM -0.243658682077616 0.384968745069576 no 2086 0.403747587953293 662 877370 SGTC_1034 k072-0165 12.7 µM -0.244145018649738 0.384767536918838 no 2087 0.403559253701234 695 5835461 SGTC_3260 9137109 49.47 µM -0.244412886761901 0.384656727230825 no 2088 0.403455531093625 661 17478346 SGTC_926 2268-1401 59.4 µM -0.244710777699182 0.384533508989801 no 2089 0.40334019116658 643 2931578 SGTC_2756 carbadox 75.1 µM -0.245698907575722 0.384124867063077 no 2090 0.402957658954531 642 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_594 1487-1584 10.8 µM -0.246651617400735 0.383730995054122 no 2091 0.402588926740702 688 5013332 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.2469681003191 0.383600180338078 no 2092 0.402466455873937 664 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_713 1488-1073 324 µM -0.247623844698254 0.383329177882418 no 2093 0.402212729898436 679 3312542 SGTC_1094 duloxetine 25.4 µM -0.248471093113189 0.382979116215837 no 2094 0.401884966630087 648 60834 A selective serotonin reuptake inhibitor. SGTC_2861 9024595 19.48 µM -0.249136397612522 0.382704296145239 no 2095 0.401627637834563 631 16482810 SGTC_538 2922-0838 53.3 µM -0.25025977845671 0.382240390687195 no 2096 0.401193229533273 664 777039 SGTC_1454 4239-0054 42.6 µM -0.250955777997471 0.381953059106113 no 2097 0.400924149644679 689 1340767 SGTC_2248 tofa 1.1 µM -0.252062971001346 0.381496107320627 no 2098 0.400496195435351 665 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1713 st033146 12.748 µM -0.252135395373899 0.381466222663534 no 2099 0.400468205993908 700 674619 SGTC_57 miconazole 162.5 nM -0.254476631181463 0.380500534041013 no 2100 0.399563677798507 666 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_638 3970-0837 4.09 µM -0.255185667472059 0.38020822465738 no 2101 0.399289850201402 648 4118451 YLR208W SEC13 SGTC_1547 harmine 94.2 µM -0.258098426923999 0.379008121269885 no 2102 0.398165472797722 630 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.258684492365013 0.378766793411566 no 2103 0.3979393428469 647 688664 SGTC_3018 9082602 49.47 µM -0.260086468027176 0.378189684973208 no 2104 0.397398537893104 659 17332089 SGTC_109 0132-0036 33.701 µM -0.261121210344935 0.37776391841592 no 2105 0.396999517729458 638 67274 A color developer. SGTC_2647 atorvastatin 60.16 µM -0.261515663875763 0.377601651245365 no 2106 0.396847435837486 677 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1138 3761-0006 1.03 µM -0.261887866048918 0.377448557468595 no 2107 0.396703947359759 661 12061087 SGTC_2803 7707263 71.43 µM -0.261943978704821 0.377425478944097 no 2108 0.396682316459196 659 2199229 SGTC_3132 9126706 49.47 µM -0.26241222021361 0.377232913381724 no 2109 0.396501826168061 698 850858 SGTC_932 2857-0803 154 µM -0.262633363357367 0.377141978286432 no 2110 0.396416591133085 680 674898 SGTC_1278 0874-0585 172 µM -0.263204103741462 0.376907318663286 no 2111 0.396196633981609 655 766306 SGTC_730 1436-0052 41.2 µM -0.263453908926443 0.376804625684938 no 2112 0.396100372165001 640 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_468 gf-109203x 121 µM -0.264319362930653 0.376448911688206 no 2113 0.39576692061113 665 2396 A protein kinase C inhibitor. SGTC_2065 5221596 34.26 µM -0.264730504235626 0.376279963454943 no 2114 0.395608538315499 653 788581 SGTC_1040 k898-0338 155 µM -0.265177400209782 0.376096349620033 no 2115 0.395436401946073 693 20969351 SGTC_2347 9049783 174.81 µM -0.265392761843778 0.376007875111541 no 2116 0.395353455762103 715 6467988 YPL169C MEX67 SGTC_2891 9063876 19.48 µM -0.268388754580288 0.374777744214419 no 2117 0.394200047319087 649 6472478 SGTC_866 0495-0101 262 µM -0.269897080494982 0.374158918514869 no 2118 0.393619716642654 658 635694 SGTC_2495 cafestol 54.53 µM -0.269986827402299 0.374122107964991 no 2119 0.393585193817459 694 16667697 An anti-infammatory. SGTC_885 0865-0106 16.8 µM -0.271003299191514 0.373705272555017 no 2120 0.393194247397563 663 2793380 SGTC_1160 4092-0570 10.5 µM -0.272373380169764 0.373143662619254 no 2121 0.392667469378986 657 4994975 SGTC_2928 9011484 9.79 µM -0.274116493476475 0.372429532554288 no 2122 0.391997549580128 686 2994751 SGTC_313 3474-0040 5.03 µM -0.274791860364534 0.372152961526013 no 2123 0.391738075975106 658 1043375 YIL048W NEO1 SGTC_151 3013-0144 2.285 µM -0.275502493043912 0.371862019916791 no 2124 0.39146510536506 693 906558 YHR107C CDC12 SGTC_16 erodoxin 22.806 µM -0.277564517365661 0.371018216898577 no 2125 0.39067333661007 684 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1253 0550-0034 176 µM -0.278198300756598 0.370758990102412 no 2126 0.390430069598292 657 5969915 SGTC_1482 3346-2049 8.48 µM -0.278620337193117 0.370586403472998 no 2127 0.390268101848789 697 3826804 SGTC_1847 st056231 15 µM -0.279003070806619 0.370429911765875 no 2128 0.390121234072774 659 5393180 SGTC_773 4358-1457 44.6 µM -0.279550364208027 0.370206172284653 no 2129 0.389911246415466 713 1186886 SGTC_779 1360-0071 233 µM -0.279658862050187 0.370161822402456 no 2130 0.389869621355815 651 7566 SGTC_1137 ixabepilone 100 µM -0.280108548684594 0.369978025642837 no 2131 0.389697113118658 638 154225 A novel microtubule stabilizer. SGTC_892 0929-0076 29 µM -0.280547195685763 0.36979876962998 no 2132 0.38952886082624 648 5751038 SGTC_2366 9070441 60.58 µM -0.281042247977108 0.369596497200402 no 2133 0.389338997967478 688 6837235 SGTC_2165 5727197 32.143 µM -0.28132879370108 0.369479434537538 no 2134 0.389229113784015 675 1361712 SGTC_2519 cryptotanshinone 88.04 µM -0.281421260801875 0.369441661489809 no 2135 0.389193656509827 668 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3200 9114385 49.47 µM -0.281950514647134 0.369225484196699 no 2136 0.388990727510296 686 17018030 YLR208W SEC13 SGTC_3163 9099914 49.47 µM -0.282475795576298 0.369010970551915 no 2137 0.38878935176422 662 16268368 SGTC_1077 5-fluorocytosine 377 nM -0.283834079696826 0.36845646525309 no 2138 0.388268768136709 699 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_216 k038-0035 28.382 µM -0.283969324699754 0.368401267865835 no 2139 0.388216944344755 658 4444231 YPR107C YTH1 SGTC_954 1189-0853 2.85 µM -0.286081285551493 0.367539668706502 no 2140 0.387407932391489 676 2828194 SGTC_3219 9131112 49.47 µM -0.2862858023179 0.367456269015245 no 2141 0.387329615687438 671 17612988 YMR079W SEC14 SGTC_385 1494-0393 12.4 µM -0.288487350380336 0.366558898473813 no 2142 0.386486856027857 691 3090647 SGTC_3149 9097855 49.47 µM -0.288887646747228 0.366395812301108 no 2143 0.386333678675662 653 25236625 YMR079W SEC14 SGTC_3093 9117344 49.47 µM -0.290513193977219 0.365733790474806 no 2144 0.385711829242759 657 24824913 SGTC_2524 avocatin b 10.57 µM -0.290831300529136 0.365604284812157 no 2145 0.385590172599073 684 6710748 SGTC_416 estradiol valerate 100 µM -0.291875891266952 0.365179125002316 no 2146 0.385190758622017 687 13791 A steroid. SGTC_2921 7974240 10.71 µM -0.292684533208977 0.364850112650093 no 2147 0.384881646580082 705 2979074 YDR527W RBA50 SGTC_823 0417-1665 178 µM -0.293225026183841 0.364630257596486 no 2148 0.384675078128173 707 3429856 SGTC_171 k064-0041 9.68 µM -0.293297002842647 0.364600983177833 no 2149 0.38464757217835 651 53325 SGTC_3287 9117173 37.0625 µM -0.293297776366952 0.364600668573542 no 2150 0.384647276578441 658 2789709 SGTC_662 k832-1615 104 µM -0.293687254227775 0.364442273494234 no 2151 0.384498447346183 685 5878478 SGTC_1246 0422-0085 105 µM -0.294566961663872 0.364084594265398 no 2152 0.38416235181023 698 264295 SGTC_3099 9120367 49.47 µM -0.294810019883566 0.363985790361329 no 2153 0.384069505846767 685 24824940 SGTC_2954 9074818 52.69 µM -0.295549753459008 0.363685142073706 no 2154 0.383786975504403 713 16648742 SGTC_2997 9067075 71.4286 µM -0.295600257036753 0.36366461907404 no 2155 0.383767688657517 699 27209819 SGTC_2767 sibutramine 71.45 µM -0.296133440817539 0.363447974527023 no 2156 0.383564088302362 707 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1955 wogonin 32.4 µM -0.296346357812717 0.363361473765472 no 2157 0.383482793277339 665 5281703 A flavanone. SGTC_2030 5175110 200 µM -0.297532445881248 0.362879735101659 no 2158 0.383030020346795 715 2831986 SGTC_330 1488-0319 80.1 µM -0.297770683124192 0.362782999375027 no 2159 0.382939095779314 665 6846614 SGTC_2931 9014674 55.67 µM -0.29813792466729 0.362633898880724 no 2160 0.382798948640082 686 2996810 SGTC_135 0933-0004 26.348 µM -0.298567495377383 0.362459519103541 no 2161 0.382635034844754 672 21230617 YGL099W LSG1 SGTC_303 1348-1668 34.2 µM -0.2996273247337 0.362029414458272 no 2162 0.382230719559206 685 5380509 SGTC_3216 9129716 49.47 µM -0.300321762455676 0.361747689078806 no 2163 0.38196586745573 665 8056934 SGTC_2835 9006588 71.43 µM -0.300965944989525 0.361486418623499 no 2164 0.381720231591828 670 2345538 SGTC_1703 st026983 48.3 µM -0.302569640022912 0.360836265481803 no 2165 0.381108927145459 689 1104023 SGTC_1769 st044406 64.4 µM -0.302671154878548 0.36079512390664 no 2166 0.381070241173114 693 670903 SGTC_458 nppb 133 µM -0.303322739175441 0.360531090540512 no 2167 0.380821959308186 671 4549 A chloride channel blocker. SGTC_307 1501-1223 22.3 µM -0.304042978971445 0.360239314125798 no 2168 0.380547573818501 701 2830329 SGTC_3113 9123498 49.47 µM -0.304321963946215 0.36012631635399 no 2169 0.380441306700824 690 8897275 SGTC_2196 6573537 42.6665 µM -0.30535375182817 0.359708515742157 no 2170 0.38004837069996 710 2903087 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.306283769964155 0.359332068230746 no 2171 0.379694297750479 667 1241132 A phosphatase inhibitor. SGTC_1646 st011709 75.6 µM -0.307382236328808 0.358887613037085 no 2172 0.37927622375173 661 5757843 SGTC_2832 7992762 51.95 µM -0.308314216012646 0.358510670456719 no 2173 0.378921624889566 653 2985177 SGTC_2924 9010168 62.78 µM -0.308572640207706 0.358406174237116 no 2174 0.378823317893836 677 2993929 SGTC_1051 3253-3903 78 µM -0.308639576141593 0.358379109799969 no 2175 0.378797856112598 657 5509239 SGTC_1383 3049-0032 20.7 µM -0.310959105868939 0.357441686660471 no 2176 0.377915855113584 710 712864 SGTC_3268 9137683 49.47 µM -0.311677920970673 0.357151356314783 no 2177 0.377642654601172 700 1953228 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.311983118495302 0.357028111639158 no 2178 0.377526676485478 669 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1141 3253-0389 52.6 µM -0.312692785216295 0.356741592155384 no 2179 0.377257038732496 712 5402031 SGTC_2635 hydroquinidine 100 µM -0.313328353840575 0.356485057480213 no 2180 0.377015605319425 663 442912 An experimental heart treatment. SGTC_3196 9111891 49.47 µM -0.31340161128107 0.356455492737114 no 2181 0.376987780108434 692 18891510 SGTC_1469 k284-2957 126 µM -0.313579692205407 0.356383627637761 no 2182 0.376920142690522 677 23884841 SGTC_302 1094-0063 18.9 µM -0.313860123702297 0.356270468992452 no 2183 0.376813638870763 696 5440289 SGTC_62 0180-0423 3.232 µM -0.314475582208887 0.356022165906633 no 2184 0.376579929517829 710 30102 YGL099W LSG1 SGTC_366 0181-0206 4.31 µM -0.315701463512701 0.355527773361016 no 2185 0.376114557875227 705 274874 SGTC_3044 9093193 49.47 µM -0.31642753091837 0.355235068082544 no 2186 0.37583901150715 719 25236277 SGTC_680 0417-1641 114 µM -0.316661266696769 0.355140858495731 no 2187 0.375750321022156 672 2835990 SGTC_164 4100-3994 89.624 µM -0.31686782621415 0.355057609947272 no 2188 0.375671947968345 695 4615967 SGTC_2088 5278280 127.392 µM -0.317400693362426 0.354842883378719 no 2189 0.375469790583462 679 791502 SGTC_2588 indole-3-carbinol 100 µM -0.317707078966266 0.354719441713846 no 2190 0.375353570498246 699 3712 Induces cell cycle arrest. SGTC_700 3453-2283 142 µM -0.318781432211614 0.354286709226475 no 2191 0.374946129616071 669 565664 SGTC_2871 9038510 12.99 µM -0.318904881851315 0.354236997701275 no 2192 0.374899321140708 746 4945164 SGTC_1511 0906-3109 28.5 µM -0.319655919825157 0.353934618262291 no 2193 0.374614589343898 679 2882180 SGTC_3211 9128781 49.47 µM -0.319753298547213 0.353895418832433 no 2194 0.374577676348226 706 17194361 SGTC_1126 isoteolin 1.0172 µM -0.321012614682936 0.353388625618812 no 2195 0.374100415644044 668 133323 SGTC_1180 1193-0155 285 µM -0.321282864421663 0.353279901428823 no 2196 0.37399802042541 710 2921347 SGTC_1662 st014054 52 µM -0.321496376197184 0.353194011958677 no 2197 0.373917129001745 690 2838777 SGTC_465 cgp-37157 41 µM -0.321547917657457 0.35317327947441 no 2198 0.373897602750872 672 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_3119 9125183 49.47 µM -0.322808939895191 0.352666170843902 no 2199 0.373419971062894 689 22695334 SGTC_527 4476-4215 268 µM -0.322965504610305 0.35260322801152 no 2200 0.373360683305874 663 4418754 SGTC_1770 st043884 66.3 µM -0.323607119140659 0.352345325497823 no 2201 0.373117748738973 686 670149 SGTC_1058 3448-5425 97.3 µM -0.324870718590038 0.351837609329663 no 2202 0.372639459523802 692 7279705 SGTC_1678 st019265 80.2 µM -0.326477478968809 0.351192392069706 no 2203 0.372031562921781 722 5367020 SGTC_148 3253-0744 288.01 µM -0.327436066828002 0.350807661654867 no 2204 0.371669045588743 674 6893655 SGTC_231 b-estradiol 524 µM -0.327493570584857 0.350784587309735 no 2205 0.371647302517457 673 450 A steroid. SGTC_1969 st069479 40.1 µM -0.328307058558384 0.350458220642572 no 2206 0.371339753870269 707 3895485 SGTC_2952 9073731 13.78 µM -0.329273242586619 0.350070736597192 no 2207 0.370974583405241 709 16457353 SGTC_3278 9139605 49.47 µM -0.329736647080883 0.349884945517488 no 2208 0.370799480292706 715 7958859 SGTC_1944 st076371 56.9 µM -0.329823971434902 0.349849938904253 no 2209 0.370766486701604 673 24208455 SGTC_2407 paclitaxel 400 µM -0.330846294930549 0.349440204561886 no 2210 0.370380294942824 752 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2262 9014885 67.46 µM -0.330949018516308 0.349399043934575 no 2211 0.370341497412847 688 6457424 SGTC_2294 7971431 200 µM -0.331661086255963 0.349113772045425 no 2212 0.370072593806148 733 5741572 SGTC_1144 3486-0183 12.5 µM -0.332133969687191 0.348924370376511 no 2213 0.369894050285175 737 6744069 SGTC_354 2783-3500 4.88 µM -0.33544226976214 0.347600368251073 no 2214 0.368645743211785 697 6740761 SGTC_2620 irigenin 100 µM -0.338253918455354 0.346476587778751 no 2215 0.367585923415273 671 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1980 st071811 45.7 µM -0.338420708089154 0.346409966387842 no 2216 0.367523085493727 726 4974850 SGTC_2247 cerulenin 830 nM -0.33920347550235 0.346097366252136 no 2217 0.367228225621655 666 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_116 0155-0182 31.788 µM -0.340103873607479 0.345737919668106 no 2218 0.366889152381349 705 771486 SGTC_2883 9059145 45.46 µM -0.340540331741754 0.345563731870255 no 2219 0.366724827680879 691 16476510 SGTC_572 0960-0087 17.7 µM -0.340743712140312 0.345482575149998 no 2220 0.36664826413342 665 6796365 SGTC_1411 3909-8223 150 µM -0.34174568259812 0.345082853564985 no 2221 0.366271144956713 715 X1411 SGTC_2343 7990716 14.84 µM -0.341817215670252 0.345054323086357 no 2222 0.366244226448782 670 6456862 SGTC_736 0958-0254 92.6 µM -0.34210752283335 0.344938545093708 no 2223 0.366134988133072 735 6812352 SGTC_145 3737-0113 38.366 µM -0.344146021028551 0.344125976850514 no 2224 0.365368237245837 691 6849351 SGTC_2734 clemastine 41.6 µM -0.344420978331997 0.34401643074878 no 2225 0.365264857224583 701 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1717 st033143 58.0435 µM -0.344437457684963 0.344009865603755 no 2226 0.365258661533985 722 674616 SGTC_2658 polymyxin b sulfate 77.05 µM -0.344980483502595 0.343793557985678 no 2227 0.365054521503185 692 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_544 k015-0020 52.4 µM -0.345475186179468 0.343596543792563 no 2228 0.36486858090499 678 3008304 SGTC_1212 0520-0165 585 µM -0.347455202175518 0.342808432718724 no 2229 0.364124683997424 772 5403258 SGTC_175 3793-3120 23.7 µM -0.347573682660436 0.342761295256327 no 2230 0.364080186783213 748 5322297 SGTC_2557 derrustone 83.84 µM -0.348912909930166 0.342228654039779 no 2231 0.363577346411813 742 629853 An antioxidant. SGTC_223 busulfan 5 mM -0.350228158745087 0.341705854915947 no 2232 0.363083737876766 698 2478 A DNA alkylator. SGTC_2335 9018011 154.17 µM -0.351318036680006 0.341272868481089 no 2233 0.362674882487112 696 6458208 SGTC_350 k064-0020 19.8 µM -0.352600219067114 0.340763750816038 no 2234 0.36219408666779 706 2790705 SGTC_1974 st069448 26.9 µM -0.352753657471496 0.340702844254061 no 2235 0.362136564513439 705 6323587 YNR016C ACC1 SGTC_2702 st077768 96.8 µM -0.353242847329033 0.340508690663866 no 2236 0.361953194096042 674 6484119 SGTC_1146 3579-1023 7 µM -0.353633538153312 0.340353660508072 no 2237 0.36180676831301 696 X1146 SGTC_2352 9027995 87.8 µM -0.354313419176198 0.340083941025627 no 2238 0.361552006089158 684 2997347 SGTC_513 4245-1575 41.7 µM -0.354973589734556 0.339822119283626 no 2239 0.361304688408516 681 719745 SGTC_1274 0865-0114 173 µM -0.355413485325428 0.339647700839351 no 2240 0.361139923832917 684 870624 SGTC_3005 9076496 71.4286 µM -0.355819981773125 0.339486555663717 no 2241 0.360987691932265 711 21368410 SGTC_1620 st003704 16.5 µM -0.356623131659916 0.339168253607502 no 2242 0.360686979059129 674 2834414 SGTC_2493 resveratrol 26.09 µM -0.356853804676149 0.339076855142093 no 2243 0.360600627100125 688 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2860 9025725 38.96 µM -0.358440296939442 0.338448503696199 no 2244 0.360006919820127 725 40546248 SGTC_3255 9139072 49.47 µM -0.36004596337026 0.337813015737345 no 2245 0.359406380732604 693 17646060 SGTC_2846 9008642 19.48 µM -0.362131923764325 0.336988128038971 no 2246 0.358626724304867 766 2992898 SGTC_654 1124-0271 80.9 µM -0.362417291567658 0.336875340895057 no 2247 0.358520109871029 712 5403748 SGTC_3229 9132204 49.47 µM -0.362757389429721 0.336740941711097 no 2248 0.358393062492185 693 17682924 SGTC_314 1671-0008 2.74 µM -0.362770920851828 0.336735594822244 no 2249 0.358388008001488 734 3913060 SGTC_3254 9136651 49.47 µM -0.362818544257357 0.336716776881115 no 2250 0.358370219081144 724 16454030 SGTC_913 3487-1245 167 µM -0.363092515481257 0.336608527668978 no 2251 0.358267887720222 689 4016153 SGTC_484 loperamide 105 µM -0.364556670070231 0.336030252877059 no 2252 0.357721182089867 689 3955 An opioid-receptor agonist. SGTC_578 3460-0051 92 µM -0.364669002819763 0.335985902529574 no 2253 0.357679249821831 746 2876744 SGTC_912 3474-0017 2.18 µM -0.364986210686062 0.33586067730273 no 2254 0.35756084976997 738 3360550 SGTC_2119 5528445 120.635 µM -0.365730581986474 0.335566890882584 no 2255 0.357283061824111 704 791935 SGTC_2523 spermine 47.74 µM -0.367077932448762 0.335035377974264 no 2256 0.356780443700637 701 1103 A DNA binding polyamine. SGTC_3187 9109394 49.47 µM -0.367229839238523 0.334975473338559 no 2257 0.356723791683973 694 17098090 SGTC_970 1315-0089 19.5 µM -0.368455546043689 0.334492268013685 no 2258 0.356266793128591 688 6811083 YLR033W RSC58 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.369696720203384 0.334003244286996 no 2259 0.35580423791578 721 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1933 st074711 15.9 µM -0.369795304880617 0.33396441390274 no 2260 0.355767506909513 698 17250958 SGTC_273 hydroxyurea 18.1 mM -0.370386363996292 0.33373164571692 no 2261 0.355547316233464 707 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1201 1889-3372 45.9 µM -0.37143355567143 0.333319402627346 no 2262 0.355157318240384 692 5392199 SGTC_845 0330-0138 4.51 µM -0.372769549416171 0.332793760369636 no 2263 0.354659984011884 733 9039800 SGTC_391 gliotoxin 8.33 µM -0.373455836644515 0.332523870598789 no 2264 0.35440460439052 717 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_2670 beta-carotene 100 µM -0.373852603323468 0.332367877456082 no 2265 0.354256990337091 696 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1684 st024538 14.6195 µM -0.374464126143431 0.332127507460873 no 2266 0.354029520763979 694 6732859 SGTC_780 0109-0199 192 µM -0.374763565346921 0.332009832698445 no 2267 0.353918156654287 740 610414 SGTC_921 1561-0023 372 µM -0.375972514537926 0.331534903790133 no 2268 0.353468664834234 717 24050882 SGTC_1166 k206-0078 225 µM -0.376179559965463 0.331453594286766 no 2269 0.353391705042649 696 5404595 SGTC_704 1310-0270 142 µM -0.37688435061041 0.331176873149921 no 2270 0.353129775880547 742 5718033 SGTC_99 0109-0120 622.8 µM -0.377901470490145 0.330777685066534 no 2271 0.352751895009378 736 759414 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.378374913454672 0.330591938932295 no 2272 0.352576050758865 700 4330530 SGTC_420 mitomycin C 81.9 mM -0.379655111498425 0.330089887157763 no 2273 0.352100722667099 685 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_441 propafenone 146 µM -0.379771736939509 0.330044165662416 no 2274 0.35205743196996 684 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2787 5284540 71.43 µM -0.381100717112463 0.329523335591716 no 2275 0.351564257659595 730 736958 SGTC_1418 3966-3099 2.4 µM -0.381703402506917 0.329287250809112 no 2276 0.35134068800595 715 740335 SGTC_2433 5607874 27.82 µM -0.382567635998013 0.328948830803206 no 2277 0.351020185325617 704 2252428 SGTC_1766 st045414 44.774 µM -0.383006124241432 0.328777179406167 no 2278 0.350857611605247 700 253960 SGTC_2102 5377816 72.7585 µM -0.383953810673033 0.328406319775708 no 2279 0.35050634107384 735 1379702 SGTC_3135 9127742 49.47 µM -0.383971384531912 0.32839944416472 no 2280 0.350499828333339 697 3643468 SGTC_2453 5731132 22.18 µM -0.3841675158662 0.328322713524388 no 2281 0.350427146512076 747 1362040 SGTC_2375 9072683 200 µM -0.384312520800952 0.328265989246287 no 2282 0.35037341449501 748 16798029 SGTC_2040 5100729 123 µM -0.38489167580401 0.328039469906374 no 2283 0.35015883672907 712 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1932 st074806 40.9 µM -0.388563313286249 0.32660489160495 no 2284 0.348799604973427 718 17251235 SGTC_2215 7188065 200 µM -0.389734593349232 0.326147787910329 no 2285 0.348366406727932 719 940217 SGTC_13 0199-0087 65 µM -0.390505490351637 0.32584708009943 no 2286 0.348081398115949 713 4589825 SGTC_344 k064-0035 6.43 µM -0.390750570313485 0.325751504198537 no 2287 0.347990807478543 727 5088750 SGTC_1086 cerivastatin 2.18 µM -0.39121057653456 0.325572142613568 no 2288 0.347820795555796 697 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2441 5730946 39.09 µM -0.39146843683553 0.325471617649203 no 2289 0.347725507341942 691 1774275 SGTC_3102 9121669 49.47 µM -0.391740438303481 0.325365593611405 no 2290 0.347625003906584 704 41905072 SGTC_1221 2958-7315 257 µM -0.392326923236798 0.325137034482801 no 2291 0.347408336556195 721 4562705 SGTC_1347 1493-0251 600 nM -0.393616292723562 0.324634785472127 no 2292 0.346932175250754 710 3986378 SGTC_2663 amphotericin b 100 µM -0.394038848703785 0.324470256237656 no 2293 0.346776178790179 712 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2983 9022671 12.99 µM -0.394655286623327 0.324230297273037 no 2294 0.346548652847 746 6405161 SGTC_2307 7538926 6.34 µM -0.395388367147515 0.32394502820142 no 2295 0.346278146414636 697 96582 SGTC_3098 9119039 49.47 µM -0.396760275372905 0.323411445186173 no 2296 0.345772123536674 691 17161528 SGTC_3259 9138485 49.47 µM -0.398224132916945 0.322842500122884 no 2297 0.345232489203582 705 17646153 SGTC_1768 st044301 37.178 µM -0.399070189919302 0.3225138592083 no 2298 0.344920743314445 764 3931349 SGTC_2551 apiole 73.87 µM -0.399177859541708 0.322472046145497 no 2299 0.344881077926799 700 10659 A possible DNA adduct former. SGTC_2327 6189656 200 µM -0.399181892733784 0.322470479915281 no 2300 0.344879592135754 745 5349088 SGTC_1967 st070177 51.4 µM -0.399400731003119 0.322385502049152 no 2301 0.344798977707018 753 5729214 SGTC_612 0302-0167 22.4 µM -0.400830161461013 0.321830663274827 no 2302 0.344272585501446 720 235821 SGTC_2122 5258151 111.688 µM -0.401207379535374 0.321684310830403 no 2303 0.344133724019782 729 2173356 SGTC_1748 st037455 53.6035 µM -0.401578109807603 0.321540502468044 no 2304 0.343997271302182 748 580690 SGTC_3265 9137266 49.47 µM -0.402488291190392 0.321187551428558 no 2305 0.343662351873299 691 17224265 SGTC_3247 9135149 49.47 µM -0.403074215321768 0.32096042658688 no 2306 0.343446814267674 732 8934436 YOR116C RPO31 SGTC_2809 7964133 12.99 µM -0.40355833583737 0.320772814941977 no 2307 0.343268764460908 735 1253665 SGTC_228 caffeine 993.056 µM -0.404951751631384 0.32023307886604 no 2308 0.342756488356388 721 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_364 0083-0097 67.7 µM -0.405143092924253 0.320158992959055 no 2309 0.342686166091193 733 5207356 SGTC_566 0958-0068 16.5 µM -0.405728999432913 0.319932178972281 no 2310 0.342470866071382 740 6815365 SGTC_1036 k216-0215 33.5 µM -0.408629601767089 0.318810301002571 no 2311 0.341405751790069 713 622330 SGTC_3215 9129942 49.47 µM -0.411443634758361 0.317723490172832 no 2312 0.3403736318712 753 17682944 SGTC_562 3772-2733 112 µM -0.411804152059144 0.317584367547563 no 2313 0.340241488920807 729 2876874 YIL048W NEO1 SGTC_1568 digitonin 820 nM -0.41285019413379 0.31718084866098 no 2314 0.339858186821899 758 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_571 k831-0106 44.2 µM -0.413718699668475 0.31684598092497 no 2315 0.339540065322922 750 4783639 SGTC_3346 9158254 43.5805 µM -0.41556169446419 0.316135878658561 no 2316 0.338865380780587 738 17639500 SGTC_2235 salicylic acid 500 µM -0.41657028202285 0.315747558581754 no 2317 0.338496375057821 719 338 A COX inhibitor and kinase inhibitor. SGTC_89 0302-0250 142.109 µM -0.417593685683732 0.315353741885037 no 2318 0.338122107096998 728 4203518 YLR208W SEC13 SGTC_774 k060-0086 136 µM -0.417659356019247 0.315328478390893 no 2319 0.338098096318815 756 5911235 SGTC_3043 9092303 49.47 µM -0.417757033133014 0.315290903429827 no 2320 0.338062384250487 721 25236084 SGTC_531 3788-1495 174 µM -0.419853183102894 0.314485006060809 no 2321 0.337296355233709 695 2896655 SGTC_945 3381-0768 11.3 µM -0.419976557508219 0.314437600341967 no 2322 0.337251289557603 739 1126236 YIL048W NEO1 SGTC_3128 9127691 49.47 µM -0.420930964821571 0.314070979700375 no 2323 0.336902746669864 745 41316314 SGTC_65 0798-0905 34.986 µM -0.421617872719883 0.313807228257195 no 2324 0.336651979323516 806 3602145 SGTC_2567 aureobasidin a 60 nM -0.422690038539325 0.313395739788132 no 2325 0.336260712219086 701 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_178 4092-0806 87.505 µM -0.423132077501203 0.313226156412265 no 2326 0.336099449858772 713 2169044 SGTC_3328 9140624 29.0385 µM -0.423152201629316 0.313218436951903 no 2327 0.33609210899636 745 4904392 SGTC_41 0478-0632 82.643 µM -0.423672572211188 0.313018855239208 no 2328 0.335902310370154 762 3750424 SGTC_1481 3346-2004 36 µM -0.42459676428768 0.312664527837615 no 2329 0.335565326099639 753 2770522 SGTC_2044 5102272 200 µM -0.425153268448987 0.312451252318471 no 2330 0.335362474086317 718 592666 SGTC_2024 5144227 134 µM -0.425219568034099 0.312425847748103 no 2331 0.335338310341519 725 3475211 SGTC_1984 st072354 53.1 µM -0.426021599866447 0.312118597108044 no 2332 0.335046053414515 722 5762938 SGTC_1718 roemerine 11.9335 µM -0.426077298516658 0.312097264342839 no 2333 0.335025760773403 730 235224 An aporphine alkaloid with mutagenic activity. SGTC_115 0527-0192 112.043 µM -0.427890039184559 0.311403323034285 no 2334 0.334365589710066 753 4233931 SGTC_1591 genipin 88.4 µM -0.428856114930821 0.311033769673926 no 2335 0.334013969398927 747 442424 A DNA cross-linking agent. SGTC_2225 6654152 15.4 µM -0.429098503033362 0.310941078724356 no 2336 0.333925770818315 745 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_3036 9090181 49.47 µM -0.429357842222421 0.310841918838413 no 2337 0.333831414346081 715 25236586 SGTC_1813 st051246 8.6015 µM -0.430397605598143 0.310444497095176 no 2338 0.333453218397339 721 5291959 SGTC_3234 9132280 49.47 µM -0.432009381372663 0.309828876187091 no 2339 0.332867297397468 726 17612295 SGTC_1218 1348-1416 30.7 µM -0.432032132528233 0.309820190149296 no 2340 0.332859029696797 726 6787668 SGTC_941 3237-0776 460 µM -0.432853012461492 0.309506861999181 no 2341 0.332560778817558 750 760008 SGTC_2966 9084041 48.03 µM -0.433534203191248 0.309246957999994 no 2342 0.332313361751268 727 17741380 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.433949153979175 0.309088682918775 no 2343 0.332162682190324 758 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_2489 cantharidin 73.42 µM -0.434082087382629 0.309037985494014 no 2344 0.332114416306907 743 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2324 6149169 200 µM -0.435268742371593 0.308585586645621 no 2345 0.331683685311169 750 2888231 SGTC_3049 9092223 49.47 µM -0.437363714063274 0.30778761147841 no 2346 0.330923797570157 752 8623917 SGTC_2331 7980721 200 µM -0.437965898886018 0.307558407047288 no 2347 0.330705501857019 715 2981221 SGTC_194 1486-1323 56.904 µM -0.439826596140061 0.306850660737084 no 2348 0.330031351642348 734 5178754 SGTC_808 0711-0032 135 µM -0.441250818019755 0.306309420717124 no 2349 0.329515713566139 749 4252555 SGTC_2801 7907800 81.82 µM -0.442675498494085 0.305768428946089 no 2350 0.329000233558038 769 6620925 SGTC_914 3820-6779 408 µM -0.443423392487815 0.305484601758759 no 2351 0.32872975947272 711 2893481 SGTC_2263 7948595 193.29 µM -0.444025004767572 0.305256373561964 no 2352 0.328512252902775 713 2971371 SGTC_196 k015-0023 18.111 µM -0.444436826791059 0.305100188008343 no 2353 0.328363396488007 716 5211998 SGTC_1809 st050081 57.6 µM -0.445443175143371 0.304718674751373 no 2354 0.327999758368439 763 5036894 SGTC_1750 st081859 2.357 µM -0.445645804439631 0.304641882317698 no 2355 0.327926559153057 748 5291695 SGTC_2770 toltrazuril 17.5 µM -0.445942635691068 0.304529404776766 no 2356 0.327819341702452 730 68591 Kills coccidiodes. SGTC_1459 k035-0031 35.7 µM -0.446796215517834 0.304206062871802 no 2357 0.327511102017876 725 3877128 YMR208W ERG12 SGTC_1874 staurosporine 7.6 µM -0.446836757277202 0.304190709179804 no 2358 0.327496464740511 765 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1689 st020265 53.493 µM -0.44833728590075 0.30362268249496 no 2359 0.326954897593006 752 5758320 YPR016C TIF6 SGTC_2667 digitoxin 100 µM -0.449787753844976 0.303074056894895 no 2360 0.326431744403291 722 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1225 1216-0074 20.6 µM -0.452205872443235 0.302160414141945 no 2361 0.325560339022946 738 4241466 SGTC_2251 lansoprazole 556 µM -0.453747803401973 0.301578469494729 no 2362 0.325005178024211 764 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_361 000s-0510 1.45 µM -0.454413560906729 0.301327359958115 no 2363 0.324765596844002 737 660 SGTC_113 0099-0221 2.5 µM -0.454503001285445 0.301293632128825 no 2364 0.324733416123032 715 89219 SGTC_2109 5483026 200 µM -0.455114946651864 0.301062914094322 no 2365 0.324513272787139 777 759335 SGTC_2507 purpurin 79.67 µM -0.457847665646571 0.300033586902663 no 2366 0.323530944074432 723 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1419 3993-2473 62.6 µM -0.459164275728809 0.299538231309208 no 2367 0.323058101201883 743 704026 SGTC_2099 5377090 177.372 µM -0.461155321161445 0.298789834108629 no 2368 0.322343586953197 756 2243829 SGTC_1366 1683-0113 21.9 µM -0.461925838055929 0.298500439281248 no 2369 0.322067252152884 742 708623 SGTC_53 0973-0023 39.979 µM -0.464392222198229 0.297574960172414 no 2370 0.321183380757985 767 674768 SGTC_2249 haloperidol 116.36 µM -0.465445219642225 0.297180235720617 no 2371 0.320806328871909 757 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2 0422-0095 29 µM -0.466133960120172 0.296922185427349 no 2372 0.3205598081596 717 6790840 SGTC_3029 9088683 49.47 µM -0.466570457575249 0.296758696086048 no 2373 0.320403613692606 733 25236615 SGTC_1633 st005664 67.9 µM -0.466632610229099 0.296735420272956 no 2374 0.320381375827114 765 2063822 SGTC_2786 7743617 45.45 µM -0.469250341814819 0.295755854716092 no 2375 0.319445352829707 749 583674 SGTC_2398 5228213 48.84 µM -0.471677738190439 0.294848843237324 no 2376 0.318578414727885 758 80771 YMR134W ERG29 SGTC_1854 st056233 32.9 µM -0.472540755869713 0.294526680652026 no 2377 0.318270429121668 772 5393174 SGTC_1654 st012436 41.8 µM -0.473098946452522 0.29431839589416 no 2378 0.318071294198429 761 4323132 SGTC_1675 st018485 24.5 µM -0.477242290667584 0.292774467953469 no 2379 0.316594799845148 756 3323024 SGTC_939 1165-0479 45.3 µM -0.477654886200239 0.292620929229952 no 2380 0.31644792943163 753 1377347 SGTC_232 clozapine 119 µM -0.478300925441716 0.292380594526898 no 2381 0.316218018895154 747 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1357 1503-1303 39.5 µM -0.479570105120424 0.291908711224811 no 2382 0.315766553895525 741 292895 SGTC_3057 9095946 49.47 µM -0.480670425863168 0.291499897257768 no 2383 0.315375376680013 748 24540043 SGTC_1529 apigenin 74 µM -0.480795732168262 0.291453357803883 no 2384 0.315330841898083 779 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1327 1436-0082 2.18 µM -0.482673681456324 0.290756292651986 no 2385 0.314663726630255 754 15992205 SGTC_2650 prasterone 100 µM -0.483056635966895 0.290614241729987 no 2386 0.314527761522508 744 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1483 3453-0561 55.9 µM -0.483554494578536 0.290429617505087 no 2387 0.314351038184342 766 4546991 SGTC_311 1315-0136 58 µM -0.483796971892121 0.290339717915556 no 2388 0.314264982161614 752 6759207 SGTC_357 1325-0123 420 µM -0.484965101705978 0.289906811072766 no 2389 0.313850550443408 774 1098503 SGTC_1317 1273-0028 910 nM -0.485196302346352 0.289821164424221 no 2390 0.313768552371971 741 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2050 5263056 171 µM -0.486098234715595 0.289487163456105 no 2391 0.31344875923341 751 763468 YGL055W OLE1 SGTC_2330 7979373 200 µM -0.488015773009625 0.288777667631037 no 2392 0.312769334410701 740 1863007 SGTC_2974 9094440 9.66 µM -0.488028239606874 0.288773057626499 no 2393 0.312764919305883 735 25236134 SGTC_182 3448-4371 550.524 µM -0.489620084379137 0.288184696581228 no 2394 0.312201380772955 712 3491403 SGTC_3085 9117376 49.47 µM -0.489699748676783 0.288155266760256 no 2395 0.31217318986323 737 16480349 SGTC_754 3474-0146 171 µM -0.491174810032085 0.287610601589798 no 2396 0.311651406807119 734 24762078 SGTC_798 1287-0182 476 µM -0.492402444837371 0.287157669830405 no 2397 0.31121743565297 772 1649755 SGTC_1343 1487-0095 224 µM -0.495229899592711 0.286115776279918 no 2398 0.310218923608683 783 4560101 YGL055W OLE1 SGTC_55 0767-0285 6.563 µM -0.495442576949779 0.286037479123745 no 2399 0.31014387329538 776 3116166 SGTC_614 0462-0418 107 µM -0.495778775987941 0.285913728241778 no 2400 0.310025250360024 746 5188303 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.498136793496054 0.285046486031666 no 2401 0.309193814399814 761 77254 SGTC_968 1309-0633 340 µM -0.499091249017187 0.284695809046624 no 2402 0.308857551091039 780 3761976 SGTC_1818 st052136 56.3 µM -0.501345823492061 0.283868273450022 no 2403 0.308063880464473 763 674169 SGTC_2884 9058502 51.95 µM -0.501506168224121 0.283809463223228 no 2404 0.308007468937072 764 6471554 SGTC_2922 7999257 32.47 µM -0.502647923515396 0.28339086617606 no 2405 0.307605914610768 770 2988377 SGTC_486 niguldipine 82 µM -0.503638536006422 0.28302792197689 no 2406 0.307257703717604 746 1236 A calcium channel blocker. SGTC_1714 st033236 13.627 µM -0.504234028865455 0.282809850572623 no 2407 0.30704846517264 773 2916566 SGTC_2081 5214970 32.255 µM -0.504852904115908 0.282583302022145 no 2408 0.30683107731544 754 2063512 SGTC_64 000l-0018 272.079 µM -0.505298265455855 0.282420324833974 no 2409 0.306674680457186 768 6811119 SGTC_770 0389-1121 67.2 µM -0.505875909900135 0.282209006843093 no 2410 0.306471882370756 739 6753108 SGTC_365 0121-0052 13.6 µM -0.507698285963892 0.28154283151751 no 2411 0.305832475334657 731 3101739 SGTC_75 0159-0059 199.013 µM -0.508756194901501 0.281156457861384 no 2412 0.305461563828361 808 5377270 SGTC_3324 9138759 60.749 µM -0.508860990248962 0.281118198038005 no 2413 0.305424832583518 756 45595710 SGTC_92 0063-0024 660.874 µM -0.508959846499649 0.281082108829843 no 2414 0.305390184814367 766 3594437 SGTC_769 0302-0231 76 µM -0.509318256683379 0.280951283676831 no 2415 0.305264581546591 778 571869 YER009W NTF2 SGTC_1268 0828-0275 2.46 µM -0.51105742170757 0.280316880265116 no 2416 0.304655424589438 767 745337 SGTC_3350 9150499 3.57 µM -0.511140311679482 0.280286661429123 no 2417 0.304626405190665 771 4910996 YPR165W RHO1 SGTC_1777 st045864 34.765 µM -0.512244708372681 0.279884186969412 no 2418 0.304239878353225 775 4691462 SGTC_588 3970-1144 52.9 µM -0.518802240862269 0.277500220385491 no 2419 0.30194932755445 743 1888707 SGTC_1886 st057356 49.9 µM -0.51900028676378 0.277428376205291 no 2420 0.301880270638429 746 24207747 SGTC_2532 xanthone 78.9 µM -0.519886099016787 0.277107145593763 no 2421 0.301571482362247 764 7020 An insecticide. SGTC_2391 6285546 200 µM -0.521784770974831 0.276419225720817 no 2422 0.300910097089526 754 846083 SGTC_589 1227-0070 34.1 µM -0.523272524092628 0.275880774365817 no 2423 0.300392309244813 745 2841384 SGTC_2747 doxorubicin 7.63 µM -0.524264791090674 0.27552193726899 no 2424 0.300047191083134 740 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_428 3448-4153 16.5 µM -0.525197908736249 0.275184700140299 no 2425 0.299722809278144 745 3834874 SGTC_2468 5987765 72.9 µM -0.525286322376506 0.275152757197473 no 2426 0.299692082083366 738 26772094 SGTC_1105 epirubicin 18.1 µM -0.528570511738095 0.273967508432704 no 2427 0.298551710436144 753 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3142 9086498 49.47 µM -0.529181448819724 0.273747302762283 no 2428 0.298339792197789 755 25236367 SGTC_863 0466-0191 129 µM -0.530147311018609 0.27339934686617 no 2429 0.298004899413423 786 765160 YPR165W RHO1 SGTC_901 1112-0062 60.1 µM -0.530578311337634 0.273244147894615 no 2430 0.297855514253619 763 1908457 SGTC_1526 st051518 75 µM -0.531723709345964 0.272831913577627 no 2431 0.297458684168942 761 673993 SGTC_3146 9095609 49.47 µM -0.531984198209015 0.272738205443188 no 2432 0.297368469931399 761 17173999 SGTC_108 0509-0257 621.132 µM -0.532465649322527 0.272565050503603 no 2433 0.297201763483003 758 536624 SGTC_2428 5615643 7.78 µM -0.533338258182368 0.27225135399167 no 2434 0.296899724342908 784 2253075 SGTC_924 2046-0044 21.3 µM -0.534759285440097 0.271740889346674 no 2435 0.296408160084068 773 3623589 SGTC_2218 6965428 192.983 µM -0.534793159782997 0.271728726743816 no 2436 0.296396446765379 763 675684 SGTC_469 w7 172 µM -0.535339638948263 0.271532550529358 no 2437 0.296207510523234 766 45115570 A P450 inhibitor. SGTC_2293 7624732 200 µM -0.535491519456525 0.271478040681354 no 2438 0.296155010131734 778 894453 SGTC_1324 1418-0026 34.4 µM -0.536366888563377 0.271163977374539 no 2439 0.295852505368978 783 1372513 SGTC_998 3996-0085 177 µM -0.536858966356591 0.270987510192083 no 2440 0.295682518437075 779 715391 SGTC_2059 5238311 157 µM -0.536974462381183 0.270946099723084 no 2441 0.295642627155324 761 703021 SGTC_606 k015-0008 38.6 µM -0.538011496182181 0.270574418427668 no 2442 0.295284555942104 791 1970475 SGTC_2005 4024620 188 µM -0.540308507629735 0.269752058856685 no 2443 0.294492146093636 786 236743 SGTC_2506 ethyl hematommate 54.16 µM -0.540564473009244 0.269660497538403 no 2444 0.294403905432811 771 3940691 An allergen. SGTC_2106 5357045 167.29 µM -0.542182368798395 0.269082120835985 no 2445 0.293846440005506 767 668842 SGTC_547 1120-0019 610 nM -0.544775571631554 0.268156384956765 no 2446 0.292953940839093 774 3676939 SGTC_554 4483-2211 187 µM -0.545043790774439 0.268060726147609 no 2447 0.29286170004102 760 747107 SGTC_39 0986-0283 58.349 µM -0.545831691568781 0.26777982525938 no 2448 0.29259081826623 758 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1104 tacrolimus 29.8 µM -0.546775640224851 0.267443485871817 no 2449 0.292266440309845 768 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_872 0588-0139 234 µM -0.546936368392226 0.26738623787638 no 2450 0.292211224448349 748 2047100 SGTC_1831 st055328 12 µM -0.548019101444317 0.267000752265089 no 2451 0.291839393532077 784 1103068 SGTC_1108 betulinic acid 729.144 nM -0.548127288415878 0.266962249870325 no 2452 0.291802252204467 744 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_1626 st003712 1.76 µM -0.54896687137445 0.266663548118354 no 2453 0.291514092519695 802 24207035 SGTC_131 0141-0277 33.849 µM -0.548992497778901 0.266654433569006 no 2454 0.291505299173128 800 1547771 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.549799234965203 0.266367581709049 no 2455 0.291228541724308 748 6312947 SGTC_1154 4088-0362 150 µM -0.549946537006459 0.266315222326738 no 2456 0.29117802186301 783 6618304 SGTC_3 0833-0587 95.581 µM -0.55015489223526 0.266241170123007 no 2457 0.29110656971086 772 5382644 SGTC_2504 purpurogallin 52.29 µM -0.55176444148921 0.265669466516901 no 2458 0.290554876250465 748 5281571 An antioxidant. SGTC_2314 7727897 200 µM -0.552005358373931 0.265583947671335 no 2459 0.290472341040392 764 900724 SGTC_2277 7947813 106.88 µM -0.552715061682873 0.265332103756498 no 2460 0.290229269073542 789 1246798 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.553040457626545 0.265216674938114 no 2461 0.290117853481272 804 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1804 st050076 49.1 µM -0.553155780984473 0.265175772008529 no 2462 0.290078371567324 773 3895976 SGTC_584 0986-0246 15.4 µM -0.553162832079269 0.265173271227645 no 2463 0.290075957647878 805 53315 YDR232W HEM1 SGTC_2445 5742597 35.57 µM -0.553682543569724 0.264988980410999 no 2464 0.28989806203125 768 1774255 SGTC_756 0508-1999 28.3 µM -0.554966169962731 0.264534082754805 no 2465 0.289458900128651 773 6753853 SGTC_2159 5658611 73.75 µM -0.555457952488696 0.264359907844533 no 2466 0.289290731395101 780 793844 SGTC_2873 9040596 71.43 µM -0.556908287720226 0.263846581937038 no 2467 0.288795045932508 826 6463863 SGTC_787 4152-0075 138 µM -0.55728103232099 0.263714736325742 no 2468 0.28866771649788 767 9566539 SGTC_1321 1326-2144 215 µM -0.557419948625791 0.26366560804701 no 2469 0.288620269497355 796 3513030 SGTC_2067 5224629 34.075 µM -0.558603519693032 0.263247223074693 no 2470 0.288216168696306 783 2835000 SGTC_3319 9138450 16.7555 µM -0.561021929759091 0.262393385812162 no 2471 0.287391293777043 785 2029690 SGTC_2666 tannic acid 100 µM -0.562175296964607 0.261986681133159 no 2472 0.28699829524544 793 16134267 A thiamine antagonist. SGTC_1567 st069303 68.4 µM -0.562262942861739 0.261955788325433 no 2473 0.286968441177864 792 5581319 SGTC_2010 4012422 159 µM -0.56262504783175 0.26182817592067 no 2474 0.286845116074988 777 952393 SGTC_1799 st045822 46.1415 µM -0.563348808046021 0.261573205196988 no 2475 0.286598694336255 797 3674992 SGTC_2531 methyl deoxycholate 70.07 µM -0.564321186501912 0.261230850452674 no 2476 0.286267782635586 799 16667744 Haematoxylin. SGTC_2274 7947094 46.08 µM -0.564490391542038 0.261171300314051 no 2477 0.286210218728779 759 2971028 SGTC_651 3253-0966 34.4 µM -0.564659604617082 0.261111754325258 no 2478 0.286152657586801 780 781462 SGTC_821 1114-0266 29.2 µM -0.565863122766882 0.260688438355549 no 2479 0.285743416040676 784 3123235 SGTC_911 3456-4043 236 µM -0.567600228033756 0.26007806605398 no 2480 0.285153226138863 786 914281 SGTC_1187 1391-0724 117 µM -0.568104722936124 0.259900938212876 no 2481 0.284981930494497 787 6997986 SGTC_383 2324-0395 7.37 µM -0.568728474657501 0.259682025440101 no 2482 0.284770210388484 781 3146421 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.568885216939004 0.259627029917702 no 2483 0.284717019144838 774 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2452 5863136 48.41 µM -0.568901374272634 0.259621361202087 no 2484 0.284711536345946 788 2184096 SGTC_126 0417-1624 672.48 µM -0.569636594800675 0.259363480566047 no 2485 0.284462101347107 806 41912 YDL195W SEC31 SGTC_2212 7123476 200 µM -0.570350161220181 0.259113321778529 no 2486 0.284220112715245 771 1085715 SGTC_2199 6590217 200 µM -0.570730888399699 0.258979899274221 no 2487 0.284091038665091 762 703109 SGTC_653 0203-0016 55.2 µM -0.571788950151424 0.258609297484485 no 2488 0.283732482087595 787 295302 SGTC_1369 1866-0067 208 µM -0.572349681139468 0.258413004539144 no 2489 0.283542549145154 784 3531355 SGTC_1968 st069590 43.6 µM -0.572416785760588 0.258389518654517 no 2490 0.283519823293987 791 6384066 SGTC_1313 1220-0047 237 µM -0.572991627046862 0.258188375805096 no 2491 0.28332518160375 777 3528706 SGTC_973 1325-0077 65.9 µM -0.573433564581216 0.258033792548683 no 2492 0.283175584804723 783 2835149 SGTC_47 0149-0135 24.25 µM -0.573603092387613 0.25797450695392 no 2493 0.283118209338609 765 5239155 SGTC_2288 7946289 167.31 µM -0.576049701612605 0.257119690365645 no 2494 0.282290793859825 799 1246052 SGTC_1373 2887-0003 58.5 µM -0.576437174961273 0.256984446955002 no 2495 0.282159861574803 786 776948 SGTC_3289 9119912 71.43 µM -0.576951980504584 0.256804816873888 no 2496 0.281985947320744 810 17014829 SGTC_3035 9091303 49.47 µM -0.578096291647373 0.256405768856699 no 2497 0.281599555289334 790 25237002 SGTC_2329 6138490 200 µM -0.578440227163649 0.256285893694996 no 2498 0.281483470767682 782 720019 SGTC_959 1222-0044 107 µM -0.578659432024965 0.256209507357189 no 2499 0.281409497169726 781 6083612 SGTC_1494 4358-1428 177 µM -0.579360984509988 0.255965117111612 no 2500 0.281172812024309 794 1564571 SGTC_2186 6124449 200 µM -0.582333036462635 0.254931134663059 no 2501 0.28017118850229 778 3834182 YLR033W RSC58 SGTC_1252 0493-0875 34.8 µM -0.58325198550919 0.254611873529242 no 2502 0.279861839974011 774 3960963 SGTC_3095 9117207 49.47 µM -0.585714980890415 0.253757214006266 no 2503 0.279033532565195 783 17015229 SGTC_1834 st055981 52.8 µM -0.586085958940081 0.253628615255034 no 2504 0.278908875725677 791 471719 YDL150W RPC53 SGTC_2949 9072542 2.23 µM -0.587301703838659 0.253207419894901 no 2505 0.27850054850939 809 16457352 SGTC_1838 st055369 84.5 µM -0.587592379947455 0.253106769542066 no 2506 0.278402963482359 760 676036 SGTC_3274 9138298 49.47 µM -0.588210323001874 0.252892868733232 no 2507 0.27819556462942 797 17015756 SGTC_204 PMA1.184 62.41 µM -0.588224387611601 0.252888001380316 no 2508 0.27819084503281 796 2252213 YGL008C PMA1 SGTC_2389 9091542 195.52 µM -0.589853502137269 0.252324545962078 no 2509 0.277644434892929 784 3626624 YOL127W RPL25 SGTC_295 k015-0027 31 µM -0.589909186538557 0.252305298322296 no 2510 0.277625767439941 790 3887424 SGTC_1895 st058434 18.3 µM -0.593035247806471 0.251225999605449 no 2511 0.276578781668993 820 5393175 SGTC_2057 5236571 38.335 µM -0.593965520932735 0.250905287088448 no 2512 0.276267587107104 786 54684039 YBR257W POP4 SGTC_2619 obliquin 87.91 µM -0.594479282652732 0.250728260192863 no 2513 0.276095797432501 798 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2505 galangin 7.89 µM -0.595264344708858 0.250457879138143 no 2514 0.27583339272951 796 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1659 st012954 42.1 µM -0.595729510679477 0.250297745544191 no 2515 0.275677970195566 804 24207262 SGTC_173 1273-0061 2.693 µM -0.597043483295094 0.24984570327621 no 2516 0.27523917474875 794 2847414 YPL266W DIM1 SGTC_1161 k007-0610 110 µM -0.597614124890136 0.249649522132375 no 2517 0.275048718606983 809 5843850 SGTC_2345 9052315 157.45 µM -0.59819503765255 0.249449893932697 no 2518 0.27485490108493 782 6469265 SGTC_1196 1588-0294 184 µM -0.59883470199955 0.249230174177369 no 2519 0.274641559404888 811 6144269 SGTC_883 0850-0245 24.6 µM -0.600605640579211 0.248622407745993 no 2520 0.27405134008455 801 6823229 YPR165W RHO1 SGTC_143 4032-1194 15.74 µM -0.601570013883548 0.248291777856313 no 2521 0.27373019704857 795 1806963 SGTC_3256 9138902 49.47 µM -0.602115447229374 0.248104882981481 no 2522 0.2735486463889 815 17228773 SGTC_3204 9114183 49.47 µM -0.602375555002906 0.248015782466412 no 2523 0.273462088995459 776 17027248 SGTC_179 1273-0063 6.77 µM -0.602388541143945 0.248011334481496 no 2524 0.273457767886314 815 3108139 SGTC_3027 9089541 49.47 µM -0.604531138155155 0.247278039992729 no 2525 0.272745286786632 798 9943819 SGTC_423 5-fluorouracil 457 µM -0.606098423642616 0.246742378350292 no 2526 0.272224698848567 808 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2737 bleomycin 30.5 nM -0.608322132117081 0.245983434027139 no 2527 0.2714869224903 805 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_43 0570-0105 72.5 µM -0.610692509546235 0.245175813270646 no 2528 0.270701582912963 806 1114046 YDL195W SEC31 SGTC_1042 0350-0096 82 µM -0.611008945011674 0.245068107261601 no 2529 0.27059682925503 791 3122515 SGTC_2032 5185112 25.99 µM -0.612394040095837 0.244596958303071 no 2530 0.270138542024764 778 5718189 SGTC_66 0109-0187 42.4 µM -0.612450040552752 0.244577919655297 no 2531 0.270120021289326 762 759417 SGTC_2257 7960413 200 µM -0.61325232348209 0.24430525270589 no 2532 0.269854756245967 795 2974689 YIL048W NEO1 SGTC_2484 5809818 12.04 µM -0.615853457750693 0.24342234915121 no 2533 0.268995620833084 801 2870548 SGTC_3334 9142812 21.919 µM -0.61642384439851 0.243228973416139 no 2534 0.268807410054009 792 45283678 SGTC_430 0958-0115 16.4 µM -0.616833993378782 0.243089973712129 no 2535 0.268672113872706 792 6833180 SGTC_3340 9146634 11.102 µM -0.617669852892548 0.242806833512855 no 2536 0.268396494168101 790 4907387 SGTC_1090 efavirenz 20.7 µM -0.617731783260429 0.242785862239228 no 2537 0.268376078656764 791 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2611 pyromycin 23.93 µM -0.618636178605383 0.242479721583417 no 2538 0.268078031320064 803 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1739 st037196 92.5 µM -0.619560062232392 0.242167200117584 no 2539 0.267773733673657 808 612214 SGTC_1206 3978-0017 132 µM -0.61991583538782 0.242046911243461 no 2540 0.267656599832226 803 3873677 SGTC_372 0155-0182 15.9 µM -0.62105108445445 0.241663294000186 no 2541 0.26728300610372 784 771486 SGTC_2969 9091408 28.7 µM -0.622202753643605 0.241274465654384 no 2542 0.266904277805229 792 4286311 SGTC_1340 1486-1359 257 µM -0.622928820616155 0.241029504633399 no 2543 0.266665648903462 808 4309068 SGTC_427 1354-0053 47.3 µM -0.623514096155117 0.240832142421146 no 2544 0.266473371006021 819 6813657 SGTC_3176 9106582 49.47 µM -0.623996206213704 0.240669634962162 no 2545 0.266315038285991 777 17018027 SGTC_2320 7373003 200 µM -0.624217035002699 0.240595218937162 no 2546 0.266242530451392 804 5415828 SGTC_3122 9126309 49.47 µM -0.626122785162142 0.239953530244988 no 2547 0.26561720410924 835 17591206 SGTC_1169 aniline yellow 25.8 µM -0.626149547463725 0.23994452571071 no 2548 0.265608428006259 815 6051 A DNA damaging agent. SGTC_2717 st081029 62.2815 µM -0.630574089079895 0.238458366102644 no 2549 0.264159522614133 821 5292846 SGTC_387 norethindrone acetate 66.7 µM -0.630920801891428 0.238342122027644 no 2550 0.264046154848344 821 541197 SGTC_1140 3229-1848 2.98 µM -0.631342662750699 0.238200724568928 no 2551 0.263908248699513 812 2849525 SGTC_1504 k297-0033 30 µM -0.631467912160154 0.238158752875191 no 2552 0.263867311786572 771 4388117 SGTC_3158 9100007 49.47 µM -0.631882422899828 0.238019877187589 no 2553 0.263731854875803 799 19297233 SGTC_671 0560-0003 407 µM -0.632003688235689 0.237979257426083 no 2554 0.263692233591477 785 3238678 SGTC_9 0092-0002 10.449 µM -0.632714627488035 0.237741193430521 no 2555 0.263460007973983 814 759368 SGTC_1151 3909-8316 15.3 µM -0.633208327338441 0.237575950766441 no 2556 0.263298804224919 815 800431 SGTC_889 0919-1524 82.7 µM -0.635044802990256 0.23696183109783 no 2557 0.26269959744943 806 3905452 SGTC_1523 st012844 44.7 µM -0.636593463246014 0.236444636157816 no 2558 0.262194842073777 814 4274103 SGTC_3327 9140648 26.9345 µM -0.63708483558938 0.236280666006222 no 2559 0.262034792822732 828 8029710 SGTC_1219 1469-0211 33.1 µM -0.638506250210421 0.235806694994181 no 2560 0.261572093373171 821 6822282 SGTC_2630 antimycin a 100 µM -0.638908060566286 0.235672806341073 no 2561 0.261441371982007 821 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1078 idebenone 36.1 µM -0.64058195802513 0.235115492439049 no 2562 0.260897162334876 829 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2340 7987427 183.45 µM -0.64112013351314 0.234936464970763 no 2563 0.260722317115627 797 2239331 SGTC_490 phenamil 164 µM -0.641460473008239 0.234823287785355 no 2564 0.260611777002275 811 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2651 TUB2.036 5 µM -0.642646083420299 0.234429257949113 no 2565 0.2602268867391 806 15992207 YFL037W TUB2 SGTC_2522 biochanin a 4.94 µM -0.643046818522717 0.234296159039369 no 2566 0.260096860496057 806 5280373 A possible chelator. SGTC_822 1487-0950 154 µM -0.643892089012896 0.234015550739487 no 2567 0.25982270603796 793 1958375 SGTC_623 k072-0108 16.9 µM -0.646402090119029 0.233183392359007 no 2568 0.259009493578808 807 5382803 SGTC_2113 5491891 107.031 µM -0.64670788076832 0.233082123797156 no 2569 0.258910510837463 814 789979 SGTC_1738 st035555 74 µM -0.647742989075061 0.232739508710535 no 2570 0.258575597299303 824 5331140 SGTC_1885 st057546 99.9 µM -0.647779673915199 0.232727371370189 no 2571 0.258563731886393 802 702008 SGTC_2430 5571206 200 µM -0.649493957705035 0.232160585514607 no 2572 0.258009575355504 826 1731771 SGTC_1176 0848-0131 83.3 µM -0.651806755435668 0.231397134611075 no 2573 0.25726292156998 830 6769040 SGTC_2126 5251174 33.877 µM -0.651878716961687 0.231373402703845 no 2574 0.257239707847137 814 790722 SGTC_1148 3909-7663 27.7 µM -0.652722908808188 0.231095101396128 no 2575 0.2569674653917 838 4084526 SGTC_256 clotrimazole 625 nM -0.6544023415601 0.230542005510805 no 2576 0.256426313113495 794 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2662 daunorubicin 22.37 µM -0.654431632882766 0.230532365423462 no 2577 0.256416880039842 795 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3110 9122132 49.47 µM -0.654783008553117 0.230416741497354 no 2578 0.25630373596234 795 918317 SGTC_221 trifluoperazine 10.304 µM -0.657190102815347 0.229625533723539 no 2579 0.255529344316984 832 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_1002 4049-0206 172 µM -0.65730677832652 0.229587221393966 no 2580 0.255491839462288 828 4662749 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.657538271721698 0.229511217319802 no 2581 0.255417435394129 828 688662 SGTC_874 0599-0792 117 µM -0.659784967950084 0.228774313266691 no 2582 0.254695915568501 827 765305 SGTC_2054 5233173 129 µM -0.660313015990288 0.228601309380423 no 2583 0.25452648954549 773 6889 SGTC_1776 st049249 45.9 µM -0.660873007484835 0.228417920196833 no 2584 0.254346878888555 821 1822314 SGTC_1174 0739-0097 51.1 µM -0.661539968691143 0.22819960786628 no 2585 0.254133045676295 816 728447 SGTC_556 4058-0063 51.5 µM -0.661631554744348 0.228169638726674 no 2586 0.254103689803865 817 6615692 SGTC_166 k072-0058 166.424 µM -0.662023353354913 0.22804145786755 no 2587 0.253978127556198 828 5846229 SGTC_621 3584-0052 32.1 µM -0.662197585741837 0.227984469000705 no 2588 0.253922300630392 834 2273927 SGTC_2508 celastrol 40.54 µM -0.662280938536025 0.227957208353429 no 2589 0.253895595300186 789 122724 Celastrol is a natural product and antioxidant. SGTC_136 0097-0015 404.482 µM -0.663404165291112 0.227590034375505 no 2590 0.253535869467149 820 4861337 SGTC_255 tunicamycin 200.472 nM -0.663763853417737 0.227472525591076 no 2591 0.253420731982142 813 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3050 9093513 49.47 µM -0.66382331550294 0.227453102839234 no 2592 0.25340170059842 833 25236664 SGTC_1407 3909-7909 12.3 µM -0.66421715318615 0.227324482910567 no 2593 0.253275668215626 794 4411780 SGTC_2555 cholic acid 100 µM -0.664981655959547 0.227074927804842 no 2594 0.253031113047001 800 6708657 Influences liver metabolism. SGTC_1106 tegaserod maleate 11.7 µM -0.665011044327034 0.227065337702909 no 2595 0.253021714544894 827 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_803 4488-1585 147 µM -0.665279490714633 0.226977748027329 no 2596 0.252935872959104 804 747204 SGTC_1117 retinoic acid 1.10837 µM -0.665549069971797 0.226889807892739 no 2597 0.252849684539989 824 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_956 1185-0240 191 µM -0.666549073673723 0.22656376206824 no 2598 0.252530103866388 822 1416193 SGTC_1479 0549-0158 134 µM -0.667277554333764 0.226326411486473 no 2599 0.252297430444411 810 5440202 SGTC_3220 9131269 49.47 µM -0.669531490696298 0.22559293342148 no 2600 0.251578249844752 832 17722206 SGTC_3166 9102297 49.47 µM -0.669572984492281 0.225579443093538 no 2601 0.251565020263992 821 25237072 SGTC_258 haloperidol 50.781 µM -0.670701801152939 0.225212621081165 no 2602 0.251205257604456 840 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_348 k064-0012 10.7 µM -0.67297770590542 0.224474067849841 no 2603 0.250480737169543 828 5066323 SGTC_3339 9145883 14.936 µM -0.674083657233095 0.224115672682288 no 2604 0.250129064501356 816 2030670 SGTC_1457 k015-0032 57.3 µM -0.674494844154855 0.223982506157891 no 2605 0.249998381262021 834 4302660 SGTC_3199 9111318 49.47 µM -0.675023961871176 0.223811212865904 no 2606 0.249830270633179 802 8548020 SGTC_598 3937-0236 20.2 µM -0.675227257137409 0.223745419121148 no 2607 0.249765695874153 847 1379313 SGTC_2130 NSC 7 2.4545 µM -0.67542646595181 0.22368095856837 no 2608 0.249702427734837 811 21448 SGTC_236 1509-0011 5.31 µM -0.676024051609285 0.223487653467847 no 2609 0.249512687342949 856 3107280 SGTC_2923 7992654 58.14 µM -0.676162583793011 0.223442855091545 no 2610 0.24946871270527 811 2985126 SGTC_1825 st052143 62.6 µM -0.677695120306456 0.222947606217433 no 2611 0.248982510512445 828 674173 SGTC_2129 girgensonine 121.053 µM -0.678510273673806 0.222684439190706 no 2612 0.24872410603629 831 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.678912914923037 0.222554514407689 no 2613 0.248596521048416 828 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2405 ticlatone 3.52 µM -0.67907042503618 0.222503700610311 no 2614 0.24854662028563 810 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_3028 9087778 49.47 µM -0.679486495637664 0.222369505325204 no 2615 0.248414830672581 815 17217395 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.679846931468607 0.222253291256865 no 2616 0.248300693386941 848 229346 A bile salt which induces apoptosis. SGTC_1571 st070080 73.4 µM -0.680419330777005 0.222068805779589 no 2617 0.248119492233191 828 4315245 SGTC_668 1682-0499 62.6 µM -0.680815266958192 0.221941245895533 no 2618 0.247994194277158 834 682214 SGTC_1068 loratadine 26.9 µM -0.681049538572593 0.221865789650857 no 2619 0.247920072588456 843 3957 A H1 histamine antagonist. SGTC_2252 omeprazole 400 µM -0.682723533197652 0.221327041441254 no 2620 0.247390778176904 817 4594 A proton pump inhibitor. SGTC_395 anisomycin 6.25 µM -0.68510750248956 0.220561092249453 no 2621 0.246638043154365 844 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2362 9071156 126 µM -0.685974113543656 0.220283034283712 no 2622 0.246364716226845 843 653133 SGTC_2638 epoxomicin 18 µM -0.687113615708831 0.219917723438225 no 2623 0.246005567369142 827 9915668 A protesome inhibitor. SGTC_457 grayanotoxin iii 135 µM -0.688724520137643 0.219401880244043 no 2624 0.245498321342718 833 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_3112 9123419 49.47 µM -0.690726635209694 0.218761733751658 no 2625 0.24486867384853 860 17015854 SGTC_3013 9080133 71.4286 µM -0.691817399682855 0.218413430836929 no 2626 0.244526004144649 837 17050193 SGTC_907 3448-6986 75.5 µM -0.692546766223072 0.218180707813392 no 2627 0.244297013799541 840 590582 SGTC_299 1273-0059 1.44 µM -0.694283655891292 0.217627084509166 no 2628 0.243752169361183 827 2848077 SGTC_2780 5215298 71.43 µM -0.694795127761861 0.21746421051408 no 2629 0.243591851004497 853 2834131 SGTC_640 3381-0960 37.1 µM -0.695041814885047 0.217385680197115 no 2630 0.243514548492599 840 1745025 SGTC_2653 dihydrofissinolide 100 µM -0.69543814329596 0.217259547401839 no 2631 0.243390381752916 837 6857746 SGTC_1691 st019933 84.6 µM -0.695688490631871 0.217179895342326 no 2632 0.243311967430171 848 6176082 SGTC_581 0958-0271 211 µM -0.697232439145506 0.216689036092242 no 2633 0.242828670508221 827 4591145 SGTC_68 0986-0284 82.829 µM -0.699820293329131 0.215867734217523 no 2634 0.242019769867178 822 423278 YIL048W NEO1 SGTC_2828 7998861 71.43 µM -0.700326375327018 0.215707331176131 no 2635 0.241861751885925 783 2988188 SGTC_4 0960-0234 25.671 µM -0.700602855543065 0.215619729772886 no 2636 0.241775447933693 817 6821112 SGTC_2400 5203494 178.7 µM -0.701207723378318 0.215428152307673 no 2637 0.241586695302773 849 6777674 SGTC_93 0109-0045 59.227 µM -0.701352718414417 0.215382243263555 no 2638 0.24154146062499 848 88733 SGTC_3017 9080681 49.47 µM -0.703783107985201 0.214613566686547 no 2639 0.240783927438846 843 16451914 SGTC_1087 pterostilbene 9.05 µM -0.703873442045561 0.214585026859781 no 2640 0.240755795967491 853 5281727 Similar to reservatol, lowers cholesterol. SGTC_2733 amorolfine 100 µM -0.70497590903725 0.214236895097618 no 2641 0.240412614266676 866 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_749 1000-0129 128 µM -0.705555960750046 0.214053861131706 no 2642 0.240232159761007 847 708470 SGTC_1602 st001878 87.6 µM -0.706369855743797 0.213797191969977 no 2643 0.239979080937286 850 595405 YLR310C CDC25 SGTC_167 3672-0051 66.205 µM -0.7064283328512 0.21377875758833 no 2644 0.239960903211662 823 3237971 SGTC_518 1021-0119 62.6 µM -0.710505609643655 0.212495716829 no 2645 0.238695326761947 849 1097762 SGTC_1009 4106-0057 9.87 µM -0.71142811769406 0.212206046517078 no 2646 0.238409490078377 828 2928005 SGTC_1861 st057647 17.4 µM -0.711792321945274 0.212091748868086 no 2647 0.23829669397978 823 688668 SGTC_2674 ligustilide 100 µM -0.712447821642981 0.211886125148007 no 2648 0.238093755718393 832 5319022 A signalling regulator. SGTC_2321 7390090 138.78 µM -0.713500724788957 0.211556084153895 no 2649 0.23776798239395 846 649046 SGTC_2086 5274770 176.623 µM -0.714038757094054 0.211387549843184 no 2650 0.23760160703331 843 689278 SGTC_262 fenpropimorph 62.5 µM -0.714449713456744 0.211258874040537 no 2651 0.237474570325205 859 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3355 9151058 44.0485 µM -0.714451800907484 0.211258220549619 no 2652 0.237473925138085 838 17015728 SGTC_1557 sumaresinolic acid 42.3 µM -0.715392408938422 0.21096387720611 no 2653 0.23718330090186 831 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_3075 9116269 49.47 µM -0.716512834165477 0.210613577848979 no 2654 0.236837372811408 845 17015205 YNL244C SUI1 SGTC_2195 6536160 144.242 µM -0.717109637930325 0.210427127397378 no 2655 0.23665322465292 829 3834386 SGTC_456 gingerol 170 µM -0.717129059350426 0.21042106148262 no 2656 0.236647233355582 860 442793 A herb. SGTC_2914 7968218 45.32 µM -0.718728818850254 0.209921759284021 no 2657 0.236154011532303 811 2977111 SGTC_3249 9135183 49.47 µM -0.72294555872698 0.208609010483046 no 2658 0.234856666007503 823 4902779 SGTC_729 4092-0585 94.1 µM -0.723375894047566 0.208475311861179 no 2659 0.234724488540698 837 2169061 SGTC_2639 lactacystin 53 µM -0.724511324938097 0.208122793433384 no 2660 0.234375938515762 839 3870 A proteasome inhibitor. SGTC_618 k072-0232 33.2 µM -0.724740713921019 0.208051617533386 no 2661 0.234305556398857 838 5872756 YGL099W LSG1 SGTC_955 1216-0110 33 µM -0.724965399773068 0.207981914874413 no 2662 0.234236628659355 855 3619719 SGTC_2204 7233102 200 µM -0.726583083297318 0.207480479764287 no 2663 0.233740697179383 840 2172480 SGTC_137 0438-0332 85.389 µM -0.726684276758273 0.207449136483328 no 2664 0.233709693764566 863 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_3279 9140807 49.47 µM -0.726859006283872 0.207395023008136 no 2665 0.233656165909865 852 45595718 SGTC_2216 7189485 200 µM -0.727735226708036 0.207123784716541 no 2666 0.233387841002016 823 731273 SGTC_470 aa-861 153 µM -0.727758651047662 0.20711653647941 no 2667 0.233380670115423 841 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2175 5807670 165.306 µM -0.730984145493123 0.2061198992635 no 2668 0.232394418530177 805 241186 SGTC_2299 7976368 114.88 µM -0.736278590131595 0.204490160786531 no 2669 0.230780586449924 848 2979718 SGTC_3341 9147222 25.867 µM -0.737315735778499 0.204171806769152 no 2670 0.230465182541866 850 1939759 SGTC_702 1488-0190 94 µM -0.737420531280753 0.204139655999239 no 2671 0.230433326838424 824 949357 SGTC_2600 tangeritin 87.95 µM -0.7380180460927 0.203956398870266 no 2672 0.230251741512425 860 68077 A bioactive flavone. SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.738693790879368 0.203749266857831 no 2673 0.230046478489131 838 3256 An antibiotic and ribosome inhibitor. SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.738869122974298 0.203695543855596 no 2674 0.229993236662273 872 5393153 SGTC_1346 1488-2224 62.4 µM -0.741431448459746 0.202911393096592 no 2675 0.229215941122389 842 3722427 SGTC_1976 st070609 63.5 µM -0.742293395432146 0.202648016510633 no 2676 0.228954796260914 847 682556 SGTC_1800 st050079 29.0735 µM -0.743546682431706 0.202265426756743 no 2677 0.228575384777652 852 3645560 SGTC_290 2043-6722 48.1 µM -0.743735497365118 0.202207824871052 no 2678 0.228518254868766 849 773758 YLR208W SEC13 SGTC_989 1501-0895 10.3 µM -0.743793898145815 0.202190010496954 no 2679 0.22850058611489 848 2830112 SGTC_2515 chrysin 20.77 µM -0.743869877544399 0.202166835406942 no 2680 0.228477600220044 844 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2115 tiliquinol 12.7705 µM -0.746272262744196 0.20143488436101 no 2681 0.22775148168995 852 71208 A bioactive hydroxyquinoline. SGTC_1132 3456-3614 2.5 µM -0.746458957322441 0.201378069436554 no 2682 0.227695107881332 863 3125502 SGTC_74 000s-0487 160.283 µM -0.748106179178827 0.20087720296119 no 2683 0.227198057583974 829 677548 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.750196282530935 0.200242747798475 no 2684 0.226568248710393 868 23847180 SGTC_2661 dactinomycin 12.96 µM -0.751166641301914 0.199948603154915 no 2685 0.226276186744669 850 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2984 9022109 38.96 µM -0.752991817561889 0.199396042303043 no 2686 0.225727415507302 883 6459207 SGTC_1390 3413-2614 145 µM -0.753527694350671 0.199233983662308 no 2687 0.225566437847781 875 3421432 SGTC_3114 9122766 49.47 µM -0.757623274225086 0.197998029656041 no 2688 0.224338271450256 824 17176985 SGTC_2878 9043973 25.97 µM -0.757647950773648 0.197990596889928 no 2689 0.224330883066916 874 6465167 SGTC_3184 9108758 49.47 µM -0.762131669477332 0.196642864946629 no 2690 0.22299071152656 875 902885 SGTC_1924 st058459 75.1 µM -0.762517824474488 0.19652705361863 no 2691 0.222875504494318 843 688683 SGTC_1379 2144-0755 36.5 µM -0.764477718633551 0.195939901318066 no 2692 0.222291304881762 874 5392327 SGTC_2910 7948405 25.97 µM -0.76482319322509 0.195836513217361 no 2693 0.222188417459347 832 2971328 SGTC_3066 9117245 49.47 µM -0.765202966586333 0.195722898937473 no 2694 0.222075346722224 840 17176980 SGTC_2108 5365811 200 µM -0.765868552027729 0.195523876683182 no 2695 0.22187725979195 849 780283 SGTC_1248 0469-0687 58.6 µM -0.76868266582318 0.194683764203374 no 2696 0.22104085886405 859 4017482 SGTC_2995 9067767 71.4286 µM -0.769320740477863 0.194493582234131 no 2697 0.220851463833936 854 11673567 SGTC_2795 7780010 54.55 µM -0.769676597921777 0.194387565928982 no 2698 0.220745877645024 867 953673 SGTC_2745 rifampicin 24.3 µM -0.770841583307463 0.194040742109496 no 2699 0.220400418035518 829 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_634 1611-4317 11.2 µM -0.774034260772112 0.193092195161115 no 2700 0.219455265527956 873 2843522 SGTC_1265 0819-1001 68.8 µM -0.775175448449889 0.192753835382043 no 2701 0.219117996833235 871 3106768 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.775799553736858 0.192568942790681 no 2702 0.218933673748818 866 803109 SGTC_2811 7967822 32.47 µM -0.777606530877046 0.192034233359566 no 2703 0.218400504856736 853 2232244 SGTC_3106 9121286 49.47 µM -0.777643483979572 0.192023307916393 no 2704 0.218389609238083 846 15943471 SGTC_2587 piperic acid 92.2 µM -0.783864557809841 0.190189429878185 no 2705 0.216559794089569 843 5370536 SGTC_150 3970-0969 77.2 µM -0.787442191188434 0.189139688390342 no 2706 0.215511528305373 889 6615640 SGTC_268 camptothecin 39.6153 µM -0.791055776007922 0.188083027828482 no 2707 0.21445572216738 887 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_528 3492-0019 172 µM -0.791545448730835 0.187940121817916 no 2708 0.214312882843541 868 2869262 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.791628205747305 0.187915976647276 no 2709 0.214288747786899 865 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2491 paeonol 100 µM -0.792232227004625 0.187739805536556 no 2710 0.214112640372339 885 11092 Increases levels of cortical cytochrome oxidase. SGTC_489 paxilline 115 µM -0.79370519675239 0.187310621551807 no 2711 0.213683537098016 882 105008 A toxic potassium channel blocker. SGTC_987 1497-1013 404 µM -0.795103475584748 0.18690376222032 no 2712 0.213276656542946 863 1676435 SGTC_1434 4073-0095 163 µM -0.795501484139535 0.186788053118282 no 2713 0.21316092399052 855 24133745 SGTC_2089 5281248 129.67 µM -0.795509793675546 0.186785637841416 no 2714 0.213158508141881 863 2737878 SGTC_2276 7947513 42.08 µM -0.795969675526028 0.186651997221333 no 2715 0.213024830638148 864 2105100 SGTC_11 0438-0307 1.3 µM -0.799943131454159 0.185499786764019 no 2716 0.21187187329549 883 4011476 SGTC_1627 st003713 25.6 µM -0.800136016661973 0.185443967086317 no 2717 0.211815997849211 885 16195070 YER133W GLC7 SGTC_2415 st077333 57.7 µM -0.800339527092552 0.185385083845825 no 2718 0.211757053811531 864 2766255 SGTC_1499 4480-0877 67.3 µM -0.801062083377494 0.185176114849548 no 2719 0.211547852732677 855 2861909 SGTC_318 1488-0629 67.2 µM -0.802517623058152 0.18475560565692 no 2720 0.211126799202239 887 3662576 SGTC_1484 3473-2379 286 µM -0.802810637110436 0.184671024970156 no 2721 0.211042096527465 897 671917 SGTC_2994 9053520 71.4286 µM -0.804452959773781 0.184197402060717 no 2722 0.210567712978147 872 4647384 SGTC_464 bw-b 70c 158 µM -0.805515472500599 0.183891391371322 no 2723 0.210261140703163 884 5353454 SGTC_371 0195-0006 7.36 µM -0.805764536584026 0.183819705101848 no 2724 0.210189314900221 855 3928593 SGTC_2406 ethylparaben 405.7 µM -0.806447403712438 0.183623249818274 no 2725 0.209992461686704 897 8434 A possible steroid mimic. SGTC_1946 st076057 65.1 µM -0.80761086945809 0.183288831735192 no 2726 0.209657313770592 860 953009 SGTC_992 3909-8734 162 µM -0.811328462798382 0.182222821679393 no 2727 0.208588534417834 879 4288319 SGTC_449 xestospongin c 11.1929 µM -0.814507415516887 0.181314345412302 no 2728 0.207677162903215 876 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1947 st076332 61.6 µM -0.815479225165681 0.181037190133058 no 2729 0.207399025750202 877 24208416 SGTC_1451 4152-0210 104 µM -0.816965071150878 0.180613947742312 no 2730 0.206974194634748 878 659563 SGTC_1983 st071813 46.9 µM -0.818042689307171 0.180307377358431 no 2731 0.206666405898168 879 11838595 SGTC_102 gallobenzophenone 83.616 µM -0.818691640787987 0.180122915504822 no 2732 0.206481183546074 855 70837 SGTC_49 0717-0965 32.132 µM -0.818967201185152 0.180044624412333 no 2733 0.206402563438565 887 5889349 YGL099W LSG1 SGTC_172 1112-0046 2.638 µM -0.821562926110059 0.179308186543018 no 2734 0.205662848348448 900 2802135 YIL048W NEO1 SGTC_1079 idarubicin 2.36 µM -0.821823493427203 0.179234365272902 no 2735 0.205588680344515 887 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_144 4161-2749 112.381 µM -0.821980010548453 0.179190031631773 no 2736 0.205544136871835 872 797501 YMR168C CEP3 SGTC_2920 7982904 15.77 µM -0.822740039214624 0.178974850781326 no 2737 0.205327920504929 862 6456808 SGTC_1245 0418-0076 17.2 µM -0.822806679108504 0.178955991316761 no 2738 0.205308968933144 883 6790114 SGTC_2311 7694451 200 µM -0.825428444916007 0.178215009497105 no 2739 0.204564195661299 872 2163142 SGTC_1882 5615643 20 µM -0.825642623400834 0.178154562429634 no 2740 0.204503424417348 848 2253075 SGTC_2777 climbazole 1.536 µM -0.82671273238342 0.177852741829316 no 2741 0.204199951476632 885 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_390 dec-rvkr-cmk 16.7 µM -0.826754570258485 0.177840948153787 no 2742 0.204188092095241 878 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2652 actinonin 100 µM -0.827629966949953 0.177594295792709 no 2743 0.203940045880791 878 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_3012 9080433 71.4286 µM -0.827940231465286 0.177506927296338 no 2744 0.203852174638327 891 17688859 SGTC_1156 4092-0367 4.88 µM -0.829550493562377 0.177053923713999 no 2745 0.203396488521153 876 1357585 SGTC_3134 9127454 49.47 µM -0.829867071709284 0.176964949024302 no 2746 0.203306971995333 891 24262820 SGTC_1425 4048-4433 7.33 µM -0.830393827671964 0.176816966222889 no 2747 0.203158077115301 922 23734946 SGTC_2278 7948257 134.34 µM -0.832238527033524 0.176299347304122 no 2748 0.202637160633549 871 1247028 SGTC_1671 st016596 74.5 µM -0.83521125236224 0.175467226471669 no 2749 0.201799387626778 886 2829167 SGTC_3083 9117465 49.47 µM -0.837584066067797 0.174804821683155 no 2750 0.201132172434075 881 16420915 SGTC_1732 st034308 51.822 µM -0.837780980065638 0.174749921749471 no 2751 0.201076861393584 862 830119 SGTC_900 1112-0045 141 µM -0.839073267050223 0.174389901761408 no 2752 0.200714098219146 865 56211 YIL048W NEO1 SGTC_312 4092-0653 6.84 µM -0.839234951526069 0.174344891051324 no 2753 0.200668738774641 869 1148278 SGTC_183 3914-0051 30.55 µM -0.8395783828897 0.174249309026538 no 2754 0.200572411937196 870 1596232 SGTC_2711 st079103 59.1 µM -0.839615634301659 0.17423894341018 no 2755 0.2005619651995 888 54693780 SGTC_1686 st019653 115.5 µM -0.840905482043824 0.173880270746586 no 2756 0.200200443522201 899 97252 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.841018536587034 0.173848855654172 no 2757 0.200168774996688 907 688801 SGTC_625 k213-0058 121 µM -0.842041671599329 0.173564715629868 no 2758 0.199882314188945 884 3655420 SGTC_910 3454-3003 490 µM -0.84358184422203 0.173137544079261 no 2759 0.199451556644331 908 820824 SGTC_2146 5545642 200 µM -0.844379311207777 0.172916627532602 no 2760 0.199228739759917 885 825326 SGTC_745 0469-0705 296 µM -0.845524739964578 0.172599632059178 no 2761 0.198908962786616 896 3486736 SGTC_674 0498-0004 451 µM -0.845700821874612 0.172550934567058 no 2762 0.198859832274811 869 4231473 SGTC_2627 acetyl isogambogic acid 100 µM -0.846234903581043 0.172403281679935 no 2763 0.198710857128823 901 6857789 A caspase activator and apoptosis inducer. SGTC_1461 k072-0203 53.8 µM -0.847013915676997 0.172188059590477 no 2764 0.198493682539872 878 5418714 SGTC_1242 0402-0103 60.1 µM -0.848458103017654 0.171789519542815 no 2765 0.198091448012508 884 432868 SGTC_2462 5162487 171.77 µM -0.849447009168346 0.171516959661142 no 2766 0.197816302342056 877 2259986 SGTC_2068 5226020 147 µM -0.849802456639616 0.171419059654447 no 2767 0.197717461801497 905 1810509 SGTC_2003 4023581 200 µM -0.850614451321237 0.171195548013101 no 2768 0.197491779550262 893 16641307 SGTC_2602 kawain 100 µM -0.851607994357327 0.170922316562998 no 2769 0.197215850525125 879 5369129 SGTC_2477 5967686 25.23 µM -0.854453958405087 0.170141201305687 no 2770 0.196426754831985 899 776118 SGTC_504 lovastatin 124 µM -0.854798987302706 0.170046658940969 no 2771 0.196331219472424 892 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2886 9058944 51.95 µM -0.857949930157432 0.16918481831115 no 2772 0.195460055901684 846 4949929 SGTC_1762 st045503 25.4615 µM -0.858734243603572 0.168970730895468 no 2773 0.19524357666569 895 4645554 SGTC_608 k048-0125 159 µM -0.860707738583742 0.168432812818445 no 2774 0.194699514952014 888 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_763 3453-1109 128 µM -0.861112377866888 0.168322655953119 no 2775 0.194588076280068 874 1560353 SGTC_3077 9117319 49.47 µM -0.861702169261813 0.168162177265134 no 2776 0.194425715787781 896 17154678 SGTC_134 0269-0018 6.916 µM -0.863716060602704 0.167614951770476 no 2777 0.193871944349678 895 4378915 SGTC_1663 st014140 55.4 µM -0.864359646639121 0.167440315191263 no 2778 0.193695176643704 893 4207120 SGTC_59 0330-0160 1.33 µM -0.865028864968206 0.167258847689217 no 2779 0.193511473015567 902 4293482 SGTC_708 3448-5400 146 µM -0.866834460094277 0.166769869092952 no 2780 0.193016358967144 905 3462195 SGTC_1353 1498-1206 8.11 µM -0.867839177479502 0.166498178394716 no 2781 0.192741189693182 858 6756808 SGTC_2550 chrysin dimethyl ether 71.87 µM -0.868823630476543 0.16623224479988 no 2782 0.192471802992248 851 88881 An O-methylated flavonoid and antioxidant. SGTC_497 capsazepine 133 µM -0.869206558527477 0.166128877311754 no 2783 0.192367080390821 898 2733484 A calcium channel blocker. SGTC_2127 5253358 187.912 µM -0.86932174653019 0.166097791621273 no 2784 0.192335585763094 890 20612 SGTC_2775 cyproheptadine 69.59 µM -0.870113867269318 0.165884124443353 no 2785 0.192119090047639 881 2913 A selective serotonin reuptake inhibitor. SGTC_2046 4110841 106 µM -0.870160678615001 0.165871503081691 no 2786 0.192106300635749 890 44119630 YMR134W ERG29 SGTC_1215 3852-0577 11.2 µM -0.871588609151735 0.165486800070532 no 2787 0.191716423512236 877 2884876 SGTC_1574 spiramycin 23.7 µM -0.875979664983427 0.164307412124127 no 2788 0.190520544339572 896 6419898 An antibiotic and protein synthesis inhibitor. SGTC_2479 5617353 43.85 µM -0.877530518153552 0.163892176018647 no 2789 0.190099275084858 884 2731746 SGTC_632 0781-2353 4.65 µM -0.880140025858623 0.163195026749077 no 2790 0.189391729153313 918 6811515 YHR007C ERG11 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.880220682731357 0.163173509415953 no 2791 0.189369885579876 901 94937 An inhibitor of serotonin biosynthesis. SGTC_1493 4348-0038 111 µM -0.880577180106056 0.163078426489342 no 2792 0.189273357186001 903 800424 SGTC_277 nystatin 15.5 µM -0.881035652758994 0.162956198252453 no 2793 0.189149261598137 917 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1873 rapamycin 2 nM -0.884269969921116 0.162095625952024 no 2794 0.188275247519065 879 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2298 7976326 193.81 µM -0.885799953668962 0.161689567960527 no 2795 0.187862667407874 892 2235818 SGTC_1850 st056238 17 µM -0.892457851277227 0.159930287422235 no 2796 0.186073787386548 888 5393177 SGTC_2704 st078022 71.1 µM -0.892987178656305 0.159790957405735 no 2797 0.185932019399892 911 54697681 SGTC_1988 st071872 53.4 µM -0.896826042561916 0.158782865350068 no 2798 0.184905874578164 894 16414116 SGTC_35 0133-0054 64.071 µM -0.899460413255772 0.158093492567328 no 2799 0.1842037362814 903 99677 SGTC_1004 4084-0029 199 µM -0.900323275348227 0.157868123090161 no 2800 0.183974119058716 897 716894 YLR208W SEC13 SGTC_1123 mangostin 811.285 nM -0.90200792489532 0.157428720713101 no 2801 0.183526328973694 847 5281650 An antioxidant. SGTC_2518 prenyletin 46.28 µM -0.902071599201634 0.157412128504323 no 2802 0.183509417289977 885 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1103 duloxetine 36.1 µM -0.902605140325544 0.157273143877678 no 2803 0.183367748715249 921 60835 A selective serotonin reuptake inhibitor. SGTC_1012 4112-3522 18 µM -0.905113737095176 0.15662074952184 no 2804 0.182702567640664 887 3112398 SGTC_7 0192-1582 4.227 µM -0.905134624657464 0.156615324919353 no 2805 0.18269703541364 931 252616 SGTC_1617 st002906 78 µM -0.907275975267666 0.156059861942992 no 2806 0.182130437760718 915 5150859 SGTC_431 k089-0097 107 µM -0.908221859574219 0.155814914951097 no 2807 0.181880508561217 887 5499420 SGTC_3351 9150312 21.596 µM -0.908488052292746 0.155746027192888 no 2808 0.181810211664425 906 4904905 SGTC_2481 5478948 45.16 µM -0.909331674902123 0.155527839608806 no 2809 0.181587537815305 901 77792 SGTC_1875 nocodazole 6 µM -0.911793266903923 0.154892346913616 no 2810 0.180938777722441 892 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_19 0279-0214 38.434 µM -0.913419441063747 0.15447347053042 no 2811 0.180510992324376 916 3566274 YBR002C RER2 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.915074801899466 0.15404784593232 no 2812 0.180076181156434 906 688788 SGTC_404 fumagillin 50 µM -0.915257968258978 0.154000798115673 no 2813 0.180028109558718 898 12015870 A methionine aminopeptidase binder. SGTC_1700 st030840 7.9285 µM -0.916940494240835 0.153569072004418 no 2814 0.17958691142785 908 5499307 SGTC_3172 9105863 49.47 µM -0.917444645536466 0.153439866002216 no 2815 0.179454843450131 918 2348785 SGTC_3069 9117009 49.47 µM -0.917932910128618 0.153314800168117 no 2816 0.179326995384108 885 41904981 SGTC_697 0508-1955 564 µM -0.918207329483081 0.153244539070266 no 2817 0.179255166080504 898 6243113 SGTC_935 2996-0153 430 µM -0.919458878136536 0.152924368767221 no 2818 0.178927802537216 884 23738523 SGTC_1997 st073024 93.8 µM -0.919551216599748 0.152900764387218 no 2819 0.178903664775874 898 686268 SGTC_340 k038-0059 454 µM -0.922477227737113 0.152154042542252 no 2820 0.178139851617721 903 23733424 SGTC_886 0866-0150 153 µM -0.922862656830956 0.152055861339458 no 2821 0.178039391702159 916 271463 SGTC_2852 9023854 51.95 µM -0.923081526922078 0.1520001268136 no 2822 0.177982360353799 907 19798528 SGTC_2461 5755302 26.15 µM -0.92678981046179 0.151057887654671 no 2823 0.177017838221326 952 2788904 SGTC_1793 st048256 72.231 µM -0.927807784768757 0.150799911552983 no 2824 0.176753642581466 883 672022 SGTC_2360 9040895 200 µM -0.928936507893412 0.150514212479816 no 2825 0.176460995807241 916 4914414 SGTC_3086 9117350 49.47 µM -0.92894265179775 0.150512658340125 no 2826 0.176459403701475 876 2679265 SGTC_592 k241-0073 46.5 µM -0.931483432555162 0.149870867892426 no 2827 0.175801775336938 906 4230158 SGTC_2596 sinensetin 100 µM -0.934619938701872 0.149081120517204 no 2828 0.174992099912337 930 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2810 7959871 45.46 µM -0.935202299625018 0.148934793188003 no 2829 0.174842026819194 895 2974535 SGTC_2217 6934799 96.0675 µM -0.936771473609966 0.148540991357616 no 2830 0.174438060961482 913 675606 SGTC_1552 6-methylflavone 10.6 µM -0.936922798766515 0.148503051452649 no 2831 0.174399135403023 906 689013 SGTC_250 brefeldin a 552.239 µM -0.939538174850832 0.147848354015659 no 2832 0.173727250941329 909 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1878 temozolomide 1 mM -0.94120950446923 0.14743098979888 no 2833 0.173298753510846 886 5394 DNA alkylating agent. SGTC_244 nsc-207895 1.295 µM -0.943947373553726 0.146748996876517 no 2834 0.1725982708832 870 42640 SGTC_117 lucigenin 22.078 µM -0.944581672723571 0.146591297806598 no 2835 0.172436243647937 945 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1693 xanthone 101.9 µM -0.946451961109515 0.146126970149025 no 2836 0.171959056698879 921 7020 An insecticide. SGTC_593 1203-0218 61.7 µM -0.948633074010804 0.145586724702881 no 2837 0.171403631710272 930 3666956 SGTC_1115 galangin 695.678 nM -0.949520022412569 0.145367418780189 no 2838 0.17117809676264 922 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2956 9076196 2.52 µM -0.950072132979055 0.145231016783164 no 2839 0.171037800899792 929 16423868 SGTC_3159 9100096 49.47 µM -0.950408139604651 0.145148046638014 no 2840 0.170952454848198 919 25236875 SGTC_540 1187-0821 17.3 µM -0.951576987353032 0.14485967148844 no 2841 0.1706557785185 913 847520 SGTC_310 1273-0058 1.06 µM -0.951748389268787 0.144817416098586 no 2842 0.170612301098898 864 2734232 SGTC_2346 9031566 143.75 µM -0.952373112150181 0.144663474611607 no 2843 0.170453895347129 918 4771086 SGTC_2048 5246248 200 µM -0.953719512064795 0.144332075508415 no 2844 0.170112820344275 890 677046 SGTC_3210 9128157 49.47 µM -0.954707742693458 0.144089161055101 no 2845 0.169862756630587 924 17590849 SGTC_1970 st070122 35.8 µM -0.95540301072071 0.1439184242914 no 2846 0.169686966032923 914 102928 SGTC_937 3122-0005 46.7 µM -0.955496313812506 0.143895522268581 no 2847 0.169663384292923 893 759535 SGTC_2808 7946468 45.46 µM -0.957089149068969 0.143504926775692 no 2848 0.169261130002831 930 2970879 SGTC_2797 7859098 81.82 µM -0.957545097465774 0.143393250871442 no 2849 0.169146097690346 899 972681 SGTC_2101 5377231 179.231 µM -0.959716905110404 0.142862113394096 no 2850 0.168598856374105 935 2844213 SGTC_1978 st071761 42 µM -0.960060069755953 0.14277831082494 no 2851 0.168512491688535 909 5147680 SGTC_516 3992-2719 87.3 µM -0.960104370192336 0.142767494853125 no 2852 0.168501344614335 944 5350887 YDR037W KRS1 SGTC_1413 3910-0535 34.4 µM -0.9615111375128 0.142424320013648 no 2853 0.168147614101106 913 2876951 SGTC_797 k781-0471 270 µM -0.96189607810302 0.142330512725361 no 2854 0.168050904415101 900 23738129 SGTC_1096 rimcazole 32.2 µM -0.962510629358817 0.14218083760457 no 2855 0.167896583213535 904 18528119 A dopamine reuptake inhibitor. SGTC_1422 4031-0024 15.5 µM -0.963030318983517 0.142054349366704 no 2856 0.167766154120487 933 782427 SGTC_3056 9094900 49.47 µM -0.963186648198112 0.142016315011706 no 2857 0.167726932167129 922 25236784 SGTC_2939 9044578 71.43 µM -0.964577892211601 0.141678133851869 no 2858 0.167378138496661 928 2653634 SGTC_2623 humulene 100 µM -0.96602070914883 0.141327993085941 no 2859 0.167016909253632 933 6187145 An anti-inflammatory. SGTC_3337 9144342 33.5465 µM -0.969043570813261 0.140596312429709 no 2860 0.166261725233945 906 17682949 SGTC_2790 5423970 71.43 µM -0.971132592144529 0.140092171885826 no 2861 0.165741127840403 924 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2094 5332512 191.667 µM -0.972761226521355 0.139699988858099 no 2862 0.165335993709206 928 755774 SGTC_2475 5812728 15.03 µM -0.975199437940122 0.139114252228137 no 2863 0.164730670445999 919 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2742 clothiapine 36.27 µM -0.976882841494964 0.138710821484012 no 2864 0.164313578681444 906 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2690 usnic acid 100 µM -0.977205309517704 0.138633632472001 no 2865 0.164233759976013 932 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1435 4092-0789 56.7 µM -0.979020988923033 0.13819956047195 no 2866 0.163784804464578 908 2248285 SGTC_1618 st003135 44.5 µM -0.982491119084041 0.137372541376023 no 2867 0.162928978013471 932 1270615 SGTC_805 3852-0218 479 µM -0.982811663297392 0.137296318509111 no 2868 0.162850070235243 919 6615355 SGTC_2678 equilin 100 µM -0.983056760247451 0.137238055891876 no 2869 0.162789751938808 871 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_384 k007-0144 5.16 µM -0.984645125634819 0.136860890879371 no 2870 0.162399207863193 934 6824886 SGTC_17 0960-0276 49.807 µM -0.986339919617878 0.136459235838474 no 2871 0.161983168376463 934 6821114 SGTC_825 1988-2224 89.6 µM -0.986382363208762 0.136449187345992 no 2872 0.16197275820621 929 1180859 SGTC_2882 9058044 58.44 µM -0.988134569669032 0.13603479532327 no 2873 0.161543373644792 916 18076804 SGTC_1712 st032288 53.4 µM -0.988230633412197 0.136012101448599 no 2874 0.161519854353223 921 2883011 SGTC_2915 7971052 15.16 µM -0.989637545735542 0.135680032686062 no 2875 0.161175655728297 889 5741558 SGTC_705 1124-0212 310 µM -0.993280042958918 0.134822888107984 no 2876 0.160286750199781 911 9554485 SGTC_253 dyclonine 31.25 µM -0.99788891954208 0.1337436717634 no 2877 0.159166612789687 927 3180 An oral anasthetic. SGTC_990 3985-0011 41.3 µM -0.99806251414122 0.133703139169609 no 2878 0.159124522949245 927 5399565 YGL099W LSG1 SGTC_29 0299-0004 12.984 µM -0.998248646279872 0.133659688569443 no 2879 0.159079401350941 933 16871 A napthoquinone isolated from Swertia calycina. SGTC_1763 st044482 94.5 µM -0.999508245364301 0.133365903506053 no 2880 0.158774273413939 924 88505 SGTC_2370 9071495 200 µM -0.999917469168158 0.133270553066527 no 2881 0.158675224800705 956 21791103 SGTC_455 paf C-16 10 µM -1.00200220586006 0.132785531034169 no 2882 0.158171263738083 927 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2357 9067248 200 µM -1.00258237887342 0.132650768041023 no 2883 0.15803120065632 972 9150235 SGTC_844 0330-0132 15.3 µM -1.00298380603398 0.132557579422589 no 2884 0.157934337366585 927 2828079 SGTC_1503 4585-0012 61.3 µM -1.00403146617759 0.132314584655792 no 2885 0.15768172347543 938 2922052 SGTC_3252 9135871 49.47 µM -1.00525611695695 0.132030928028434 no 2886 0.157386769922082 937 17682838 SGTC_288 1315-0019 35.1 µM -1.0091906219182 0.131122447530513 no 2887 0.156441611678393 928 6811474 SGTC_2576 guaiol 23.12 µM -1.01278313881821 0.130296711932919 no 2888 0.155581878086208 905 227829 SGTC_2715 st079500 56.4 µM -1.01335746906823 0.130165037099509 no 2889 0.155444723270959 920 28246688 SGTC_1927 st060202 13.8 µM -1.01362361305577 0.130104050363173 no 2890 0.155381192943013 910 688887 SGTC_699 0375-0592 111 µM -1.01703298831985 0.129324543085009 no 2891 0.154568868314444 883 762578 SGTC_3314 9135860 59.4275 µM -1.01772720219458 0.129166217988684 no 2892 0.154403808085985 906 25252478 SGTC_2411 st077133 39.94 µM -1.02186766441698 0.128224719055443 no 2893 0.153421769303069 961 1403142 YNL221C POP1 SGTC_1909 st060837 51.5 µM -1.02204848288222 0.128183711666814 no 2894 0.153378977101134 921 678937 SGTC_2384 9036245 200 µM -1.02291858629901 0.127986510356135 no 2895 0.153173170426926 902 6462766 SGTC_2063 5246145 200 µM -1.02382322896283 0.127781704620129 no 2896 0.152959388282405 945 711240 SGTC_1642 st009582 77.7 µM -1.02453025579407 0.127621796592701 no 2897 0.152792443838805 932 6739311 SGTC_2219 9098279 200 µM -1.02609238737688 0.127268983201151 no 2898 0.152424019125206 914 902349 SGTC_1456 k015-0012 13 µM -1.02616802914821 0.127251916457757 no 2899 0.152406194186529 934 2989616 SGTC_2784 7567673 72.73 µM -1.027741640348 0.12689723005514 no 2900 0.152035687407893 917 3471247 SGTC_1698 5-fluorocytosine 1.055 µM -1.02872279913979 0.126676428965681 no 2901 0.151804976595011 932 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_884 0851-0618 334 µM -1.02892686573671 0.126630539217626 no 2902 0.15175702137807 937 9642473 SGTC_2580 diallyl disulphide 81.36 µM -1.02952258594281 0.126496642079934 no 2903 0.151617085989828 926 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1508 1080-0625 72.9 µM -1.03125714730873 0.126107334945022 no 2904 0.151210124044237 916 767111 SGTC_1116 jasmonic acid  1.58368 µM -1.03404708363559 0.125482911726671 no 2905 0.150557076232509 936 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2014 4013930 200 µM -1.03515986254318 0.125234460635954 no 2906 0.150297129955381 951 64556 SGTC_817 1391-0715 46 µM -1.03650742583774 0.124934049123531 no 2907 0.149982738439016 946 1353946 SGTC_2107 5363541 170.161 µM -1.03892914825874 0.124395442022241 no 2908 0.149418844504674 935 244052 SGTC_985 1493-0307 8.71 µM -1.03966161590482 0.124232856668012 no 2909 0.149248569774289 956 3278274 SGTC_746 1095-0025 46.6 µM -1.0397816329711 0.124206230739554 no 2910 0.149220682097743 941 6749286 SGTC_981 1488-1094 54.9 µM -1.04184842656278 0.123748336327014 no 2911 0.148740979072829 929 3449522 SGTC_984 1492-0255 2.91 µM -1.04484928051806 0.123085608315278 no 2912 0.148046317164865 948 1585198 SGTC_3140 9094243 49.47 µM -1.04668595921168 0.122681213734782 no 2913 0.1476222208088 954 19291112 SGTC_2794 7785382 27.27 µM -1.047556621522 0.122489839802502 no 2914 0.147421466027499 928 2205081 SGTC_3202 9113761 49.47 µM -1.04989474628653 0.121976950582878 no 2915 0.146883253661893 940 4798415 SGTC_3097 9117246 49.47 µM -1.04995677647098 0.121963364259833 no 2916 0.146868992918753 925 16423892 SGTC_1579 chlormadinone acetate 49.4 µM -1.05074735990371 0.121790297756424 no 2917 0.146687319089694 956 45114258 A steroidal progestin. SGTC_2682 pyrogallin 40.03 µM -1.05187561714366 0.121543610069243 no 2918 0.146428310039196 940 822798 An ATP competetive kinase inhibitor. SGTC_739 1486-1183 203 µM -1.05323544467586 0.121246757730042 no 2919 0.146116548668268 936 4346692 SGTC_185 k048-0037 25.491 µM -1.05359590545418 0.121168154180245 no 2920 0.146033982308738 934 6827589 SGTC_1741 st038134 10.228 µM -1.05413577695565 0.121050494648681 no 2921 0.145910379160793 961 1272587 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.05722645846983 0.12037845912154 no 2922 0.145204123638554 919 6708739 YPR165W RHO1 SGTC_3262 9137218 49.47 µM -1.05750313995256 0.120318426114436 no 2923 0.145141011175006 910 17650664 SGTC_687 k029-0044 34.9 µM -1.05882200910736 0.120032554154053 no 2924 0.144840424121997 946 5829338 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.05882298049156 0.120032343777896 no 2925 0.144840202885779 929 17037758 SGTC_298 1391-0729 10 µM -1.06009810117909 0.119756410359459 no 2926 0.144549985784995 947 3237558 SGTC_1971 st069429 63.5 µM -1.06121189927357 0.119515753056178 no 2927 0.14429680643804 928 1246522 YGL099W LSG1 SGTC_3145 9085516 49.47 µM -1.0626525823603 0.119204972360281 no 2928 0.143969765916706 959 25236195 SGTC_3090 9117696 49.47 µM -1.06330437407807 0.119064556990712 no 2929 0.143821971104747 912 7923821 SGTC_718 1130-0073 349 µM -1.06360935390894 0.118998895361904 no 2930 0.143752851606683 954 6740020 SGTC_1773 st048542 73.5835 µM -1.06554444943411 0.118582868442742 no 2931 0.1433148110641 942 3237138 SGTC_3162 9099653 49.47 µM -1.06597814253814 0.118489769753952 no 2932 0.143216761309656 910 25237511 SGTC_1089 terbinafine 2.25 µM -1.06635513963715 0.118408883687259 no 2933 0.143131566261936 929 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1017 4239-0030 168 µM -1.07068653147524 0.117482367627519 no 2934 0.142155200375704 924 1149593 SGTC_1398 3558-0053 112 µM -1.07102671382994 0.117409818170188 no 2935 0.142078709127973 929 4532369 SGTC_3261 9137475 49.47 µM -1.0727205431759 0.117049053586906 no 2936 0.141698260149826 904 17027690 SGTC_205 1486-1330 71.903 µM -1.07418876987313 0.116736975667547 no 2937 0.141369042311632 952 4118834 SGTC_215 1287-0124 461.5 µM -1.07420543540935 0.116733436725192 no 2938 0.14136530840647 961 5560863 SGTC_1088 bifonazole 369 nM -1.07433367130432 0.116706208256178 no 2939 0.141336579453528 938 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2443 5493264 126.67 µM -1.07902744831822 0.115712670721979 no 2940 0.14028774585219 961 5340055 SGTC_938 3126-1755 342 µM -1.08206252395598 0.115073439389597 no 2941 0.13961237333052 933 1777771 SGTC_1181 1222-0449 220 µM -1.08453474964833 0.114554611325026 no 2942 0.139063884093669 969 658318 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.08662666260719 0.114116898933263 no 2943 0.138600918387664 933 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2862 9027634 71.43 µM -1.08790710424976 0.113849567476563 no 2944 0.138318059774692 938 5012562 SGTC_3214 9129694 49.47 µM -1.0891536690637 0.11358973787214 no 2945 0.138043063053189 972 17158655 SGTC_2693 st077581 40.7 µM -1.08972150713564 0.113471519953896 no 2946 0.137917919608913 913 25238761 SGTC_156 3474-0145 5.642 µM -1.09039295902744 0.113331843972225 no 2947 0.137770041040225 908 2265471 SGTC_331 k048-0133 24.5 µM -1.09327574018332 0.112733559045348 no 2948 0.137136375550725 946 6813582 SGTC_964 1287-0107 19.4 µM -1.09331112682632 0.112726229031591 no 2949 0.137128609586432 955 51516812 YPR165W RHO1 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.09389565982538 0.112605197698982 no 2950 0.137000371252699 947 165521 SGTC_1709 st033179 39.1045 µM -1.09614434968823 0.112140457288586 no 2951 0.136507804423232 954 573381 SGTC_146 3448-8650 53.125 µM -1.09695445669429 0.111973367545299 no 2952 0.13633065075807 976 2891488 YIL048W NEO1 SGTC_1309 pyrazolanthrone 13.4 µM -1.0977943447174 0.111800323304935 no 2953 0.136147150740679 961 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3181 9108277 49.47 µM -1.10025788351596 0.111293857752968 no 2954 0.13560988842929 965 17097298 SGTC_2028 5153890 36.43 µM -1.10122868698466 0.111094727371073 no 2955 0.135398569684597 966 2830968 YPR165W RHO1 SGTC_1877 wortmannin 25 µM -1.10473672796946 0.11037728810456 no 2956 0.134636841950113 960 312145 A covalent inhibitor of PI 3-kinase. SGTC_2399 5884133 200 µM -1.10627454752141 0.110063833919572 no 2957 0.134303852453462 963 722445 SGTC_1041 0206-0046 107 µM -1.10627829086532 0.110063071692716 no 2958 0.134303042584635 967 50494 SGTC_1402 3909-7673 35.9 µM -1.1070434296538 0.10990735215631 no 2959 0.13413757594808 958 5328014 SGTC_1930 st074634 34.3 µM -1.10744071513531 0.109826559786933 no 2960 0.134051715431089 956 684253 YOR116C RPO31 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -1.10859563955451 0.10959193530773 no 2961 0.133802330023446 959 368090 SGTC_3154 9100113 49.47 µM -1.10928183270699 0.109452704783491 no 2962 0.133654309925343 956 25237525 SGTC_397 arbidol 50 µM -1.11076234976821 0.10915273654817 no 2963 0.133335328256112 953 131410 A RNA synthesis inhibitor. SGTC_778 3456-2434 196 µM -1.11130461139956 0.109043016617775 no 2964 0.133218627575454 870 5539063 SGTC_683 panaxydol 45 µM -1.11192268392518 0.108918053983773 no 2965 0.133085697289417 942 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_320 4092-0846 5.34 µM -1.1147755783759 0.108342586676127 no 2966 0.132473302130441 939 1359356 SGTC_1676 st018489 23.4 µM -1.11535688263264 0.108225598586266 no 2967 0.132348759332115 938 3696235 SGTC_1767 st044992 70.3 µM -1.11680514842817 0.107934529095387 no 2968 0.132038823529344 954 9600693 SGTC_487 nimodipine 119 µM -1.11683373628774 0.10792878924524 no 2969 0.132032710632532 958 4497 L-type voltage-gated calcium channels inhibitor SGTC_1610 st001799 48.1 µM -1.12278276771314 0.106739124935487 no 2970 0.13076488288456 959 621897 SGTC_1505 k297-0037 20.6 µM -1.12401307644681 0.106494277986298 no 2971 0.130503739281971 951 4089396 SGTC_1399 3562-5772 25 µM -1.12438332433083 0.106420673426628 no 2972 0.130425221634383 938 23847490 SGTC_1216 1165-0504 9.65 µM -1.12595330387794 0.106108972663267 no 2973 0.130092642610551 976 6304004 SGTC_1583 clindamycin 39.6 µM -1.12624460221631 0.106051211459593 no 2974 0.130030999590669 974 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1445 4239-0156 97.7 µM -1.12933085802294 0.105440636433337 no 2975 0.12937914408864 987 4008346 SGTC_3290 9121031 71.43 µM -1.13137656869258 0.105037323276658 no 2976 0.128948314648868 943 17014854 SGTC_2765 myclobutanil 7.74 µM -1.13464809412881 0.104394662669335 no 2977 0.12826139675495 970 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_869 0564-0080 44.1 µM -1.13505962224233 0.104314024004066 no 2978 0.128175168995045 949 6843321 SGTC_1835 st008666 49.2 µM -1.13571157882811 0.104186365960541 no 2979 0.128038646525319 941 690455 SGTC_272 doxorubicin 8.13 µM -1.1420243639951 0.10295612835452 no 2980 0.126721946269878 966 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1760 st045453 10.4495 µM -1.14471487768924 0.102435019939756 no 2981 0.126163643209849 967 3323419 YIL048W NEO1 SGTC_1266 0828-0227 32.9 µM -1.14767672573161 0.101863579199841 no 2982 0.125551021357837 970 3913820 SGTC_3183 9108214 49.47 µM -1.14802444299022 0.101796645260962 no 2983 0.12547923670814 957 4974831 SGTC_792 4534-1957 155 µM -1.14825489396501 0.101752302175318 no 2984 0.125431676936638 960 1717904 SGTC_620 0109-0052 432 µM -1.14985274271171 0.101445232853412 no 2985 0.125102263821436 973 493037 SGTC_2476 5806916 10.51 µM -1.15209428248115 0.101015599539123 no 2986 0.124641166178579 936 2870194 SGTC_2996 9066192 71.4286 µM -1.15542972216914 0.100378757236662 no 2987 0.123957248175814 952 6472854 SGTC_3010 9080089 71.4286 µM -1.15930283396355 0.0996429384229717 no 2988 0.123166383500704 960 17027233 SGTC_163 TUB2.036 7.546 µM -1.16310090499788 0.0989252110293751 no 2989 0.122394282493634 937 15992207 YJR013W GPI14 SGTC_2143 5623677 140.463 µM -1.16625078695846 0.0983328479443502 no 2990 0.121756532109502 924 5375313 SGTC_1559 coumarin 343 70.1 µM -1.16876108691421 0.097862627199668 no 2991 0.121249951209261 962 108770 A hepatotoxic, DNA x-linker. SGTC_2342 7990637 118.86 µM -1.16988011502507 0.0976535466246091 no 2992 0.121024608593341 1000 2033102 YER133W GLC7 SGTC_3062 9077494 49.47 µM -1.17140601827621 0.0973689730800612 no 2993 0.120717807167324 860 16459633 SGTC_2732 terfenadine 20 µM -1.17508129612474 0.0966860498180886 no 2994 0.119981096411973 990 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_737 1950-0117 57.9 µM -1.17561450286006 0.0965872647323308 no 2995 0.119874478732253 963 5393513 SGTC_3148 9097893 49.47 µM -1.1788197309304 0.0959950069469198 no 2996 0.119234982909197 935 17174100 SGTC_1183 1254-0324 198 µM -1.17927371590823 0.0959113365873941 no 2997 0.119144600470065 955 5799357 SGTC_793 0488-0545 106 µM -1.17938061332876 0.0958916429781778 no 2998 0.11912332563601 974 292548 SGTC_2826 7992541 19.48 µM -1.1803401920356 0.0957149938748384 no 2999 0.118932469383885 1009 2985066 SGTC_1305 1181-0477 144 µM -1.18188360160375 0.0954313696077648 no 3000 0.118625944756348 987 6252086 SGTC_1524 corynanthine 62.1 µM -1.18294521753298 0.0952366414453233 no 3001 0.118415429725644 992 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2525 harmine 47.85 µM -1.18302205195486 0.0952225593624674 no 3002 0.118400203960498 938 5280953 A monoamine oxidase inhibitor SGTC_2545 solidagenone 89.61 µM -1.18455993813416 0.094941020578473 no 3003 0.118095742324809 918 6708572 An anti ulcer agent SGTC_2390 9097792 176.6 µM -1.18659746289327 0.0945689587264006 no 3004 0.117693218572869 960 4497149 SGTC_2285 7945142 200 µM -1.18810359490142 0.094294623470524 no 3005 0.11739629911226 958 2970608 SGTC_1403 3909-7815 62.9 µM -1.19002303673014 0.0939458568988257 no 3006 0.117018668895463 952 6615483 SGTC_1125 tnp00248 1.32998 µM -1.19015966663101 0.0939210673041428 no 3007 0.116991821238016 963 24207736 SGTC_856 0433-0016 11.3 µM -1.19148682598875 0.0936805238540996 no 3008 0.116731262684019 975 3911780 SGTC_1400 3771-8998 51.5 µM -1.1929968104968 0.093407397434573 no 3009 0.116435311092012 977 670767 SGTC_105 0111-0055 734.78 µM -1.19604811492281 0.0928572727289522 no 3010 0.115838891678053 984 5179370 SGTC_1024 4507-0395 26 µM -1.19829667799439 0.0924534113407514 no 3011 0.115400769708472 976 4201836 SGTC_2061 5245884 80.95 µM -1.20037522249627 0.092081244071953 no 3012 0.114996823648562 981 573863 SGTC_104 0074-0074 590.992 µM -1.20127900921261 0.0919197658295627 no 3013 0.114821495035841 973 3943124 SGTC_519 k048-0011 62.8 µM -1.20196225881772 0.0917978298990473 no 3014 0.114689075438565 949 6836379 SGTC_495 decylubiquinone 155 µM -1.20309903345738 0.0915952213450205 no 3015 0.114468999693825 979 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_321 4534-3890 65.3 µM -1.20322823419585 0.0915722147473941 no 3016 0.114444005903444 971 699746 SGTC_1471 k673-0312 37 µM -1.20790721733413 0.0907419177760045 no 3017 0.113541476565733 979 24099884 SGTC_660 4031-1742 102 µM -1.21153052994765 0.0901028003364905 no 3018 0.112846070587292 944 6738706 SGTC_2585 alliin 100 µM -1.21371997012707 0.0897182286119577 no 3019 0.112427337905008 990 87310 A garlic compound which reacts with lipids. SGTC_2312 7706453 155.7 µM -1.21626641647303 0.0892724858501321 no 3020 0.111941725181046 979 976098 SGTC_263 alizarin 107.927 µM -1.21785417669989 0.0889953915211862 no 3021 0.111639696110042 1000 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1429 4049-0205 9.46 µM -1.21787111848856 0.0889924383131527 no 3022 0.111636476532911 970 22774478 SGTC_1474 0330-0125 5.35 µM -1.21941135283276 0.0887242570329974 no 3023 0.111344051557485 1012 X1474 SGTC_2985 9022375 71.43 µM -1.22038008929204 0.0885558919517643 no 3024 0.111160410825785 986 4939335 SGTC_1306 1185-0270 9.02 µM -1.22074433756305 0.0884926477041164 no 3025 0.111091417407736 978 1548076 SGTC_335 4077-0256 27.6 µM -1.22576863886906 0.0876237111756669 no 3026 0.110142875994191 952 3121989 SGTC_141 0443-0274 32.331 µM -1.23340030261893 0.0863160425664315 no 3027 0.108713226080224 871 1627241 SGTC_2791 5663188 71.43 µM -1.23348267178668 0.0863020088401579 no 3028 0.108697868891198 970 54690634 SGTC_264 promethazine 12.5 mM -1.23577025676242 0.0859129407957766 no 3029 0.108271986908361 980 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1851 st056236 18.9 µM -1.23684489318178 0.0857306225020718 no 3030 0.108072335886638 957 5393171 SGTC_398 bronopol 33.3 µM -1.23698497862277 0.0857068775503413 no 3031 0.108046329693243 969 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_994 3910-0338 138 µM -1.23871272181612 0.0854144240032191 no 3032 0.107725952840291 985 3479481 SGTC_1912 st060209 90.8 µM -1.23933628153309 0.085309058374964 no 3033 0.107610493878791 994 688787 SGTC_2594 a-mangostin 100 µM -1.24326295380811 0.0846477874916672 no 3034 0.106885475473862 996 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_1061 3448-9325 110 µM -1.24380825819412 0.0845562604007419 no 3035 0.106785070151537 968 723482 SGTC_3020 9089140 49.47 µM -1.24520029042542 0.0843229502013646 no 3036 0.106529067945438 1002 17217859 SGTC_2142 5622915 118.518 µM -1.24665379162325 0.0840798534723753 no 3037 0.106262234419993 983 5322196 SGTC_2888 9058547 12.99 µM -1.25067659434068 0.0834097870038629 no 3038 0.10552624658222 960 16476514 SGTC_1045 1348-1485 165 µM -1.25082356714261 0.0833853823948717 no 3039 0.105499427299484 986 6810614 SGTC_287 k060-0039 29.6 µM -1.25126649204769 0.0833118678520143 no 3040 0.10541863312382 976 5861974 SGTC_1742 st038235 28.8875 µM -1.25339550414461 0.082959184509177 no 3041 0.105030903420245 986 564103 YBR002C RER2 SGTC_747 3448-8087 38.7 µM -1.25423123071478 0.0828210488698959 no 3042 0.104878985710092 1009 5168703 SGTC_3221 9128209 49.47 µM -1.26018275224543 0.0818423336747505 no 3043 0.103801721681288 985 16460723 SGTC_209 4077-0173 175.592 µM -1.26095670340471 0.0817157022001912 no 3044 0.103662223406785 984 15993494 SGTC_2659 sanguinarine 24.21 µM -1.2617369426117 0.081588191458547 no 3045 0.103521729499104 954 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1478 0453-0656 35.7 µM -1.26251436735571 0.0814612899432835 no 3046 0.103381879873246 1015 5258496 SGTC_1360 1598-0022 39.8 µM -1.26306054955126 0.081372223952822 no 3047 0.103283710135022 989 761525 SGTC_1354 1498-1681 81 µM -1.26742240661081 0.080663569328601 no 3048 0.102502146072011 999 5754243 SGTC_672 1441-0018 53.7 µM -1.26803481636963 0.0805644476832849 no 3049 0.102392758732236 970 251141 SGTC_3280 9140961 49.47 µM -1.27128457985959 0.080039995826112 no 3050 0.101813713056372 1009 4901226 SGTC_1846 st056244 14.8 µM -1.27288177047716 0.0797831866641409 no 3051 0.101529999469856 984 5393182 SGTC_517 1365-0151 113 µM -1.2772142896349 0.079089707887075 no 3052 0.100763301716585 987 768657 SGTC_496 calpeptin 138 µM -1.28028278720045 0.078601321105324 no 3053 0.100222849551353 980 73364 A calpain inhibitor. SGTC_1023 4482-3888 16 µM -1.28056849430448 0.0785559641051865 no 3054 0.100172636060509 983 3303168 SGTC_2221 6807166 181.081 µM -1.28639449256063 0.0776353880023562 no 3055 0.099152709760797 978 674925 SGTC_2144 5628481 200 µM -1.28656217121981 0.0776090145837881 no 3056 0.0991234680066883 975 2818399 SGTC_1806 st050005 60.3 µM -1.29059351093756 0.0769769891954149 no 3057 0.0984223336565747 980 5194765 SGTC_413 propylparaben 100 µM -1.29174015671558 0.0767979369259753 no 3058 0.0982235729042837 984 7175 A pharmaceutical preservative. SGTC_2841 9004761 38.96 µM -1.29961972088528 0.0755760730563109 no 3059 0.0968656685914616 986 2991039 SGTC_649 1123-0311 367 µM -1.30192159902025 0.0752219371087162 no 3060 0.0964715940378375 980 693629 YIL048W NEO1 SGTC_2773 thioridazine 9.09 µM -1.30215383914492 0.0751862781511668 no 3061 0.0964319007455288 999 5452 An antipsychotic. SGTC_2140 5586273 200 µM -1.3049248933999 0.07476179463044 no 3062 0.0959592118835167 990 854421 SGTC_2741 miltefosine 3.04 µM -1.3079492942376 0.0743005919251183 no 3063 0.0954452541267609 972 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2959 9079155 11 µM -1.30913287795913 0.074120695276475 no 3064 0.0952446719968335 995 16189457 SGTC_1694 st024011 44.9 µM -1.31420836878251 0.073353026021134 no 3065 0.094388046490299 1002 2787533 SGTC_2617 dihydrotanshinone i 20.83 µM -1.31540593037193 0.0731727844008811 no 3066 0.0941867567529085 986 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1948 st076329 66.6 µM -1.31554118318933 0.073152449196221 no 3067 0.0941640429709131 1000 24208413 SGTC_1845 st056753 3.01 µM -1.31710755383913 0.0729172609392604 no 3068 0.0939012876778628 988 5375839 SGTC_2163 5671233 125 µM -1.31716509305889 0.072908632544254 no 3069 0.0938916459125296 962 701023 SGTC_2473 5854593 8.94 µM -1.318533775051 0.0727036197594874 no 3070 0.093662513177387 987 2872951 SGTC_422 cantharidin 155 µM -1.31903315337787 0.0726289286587524 no 3071 0.0935790145210207 999 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2859 9028643 45.46 µM -1.32131503719388 0.0722883790815524 no 3072 0.0931981710616403 956 17151580 SGTC_14 0354-0009 295 µM -1.32415321364532 0.071866517195237 no 3073 0.0927260827988777 1002 1713507 SGTC_125 0133-0007 11.75 µM -1.32968981170563 0.0710490035253249 no 3074 0.0918102465229684 991 26541 SGTC_2854 9024559 71.43 µM -1.33115587648101 0.0708337303171353 no 3075 0.0915688632220488 993 3163529 SGTC_1267 0828-0272 9.49 µM -1.33254347679198 0.0706304405692802 no 3076 0.0913408323810154 997 745334 SGTC_784 4579-0127 173 µM -1.3339332008773 0.0704272894035221 no 3077 0.0911128747456367 1002 1948547 SGTC_72 0744-0168 198.391 µM -1.33411933282617 0.0704001146089384 no 3078 0.0910823754297824 1013 677577 SGTC_1606 st000094 49.2 µM -1.3391382732681 0.069670397552103 no 3079 0.0902628313897552 983 1242210 SGTC_2893 9048488 25.97 µM -1.34132126290342 0.0693548298669389 no 3080 0.0899080845818329 1017 6467338 SGTC_2174 5790901 200 µM -1.34152213785614 0.0693258472769245 no 3081 0.0898754935234608 999 786020 SGTC_2738 aclarubicin 5.55 µM -1.34162628942479 0.0693108237793151 no 3082 0.0898585988564465 1013 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2933 9026794 32.47 µM -1.34232558903475 0.0692100172117581 no 3083 0.0897452249742172 984 17586027 SGTC_605 1315-0399 119 µM -1.34301206747948 0.0691111687720929 no 3084 0.0896340331876481 1000 24020461 SGTC_347 4534-1311 26.2 µM -1.34446813439075 0.0689018647284823 no 3085 0.0893985270461232 998 2862016 SGTC_217 ketoconazole 989 nM -1.34627550766424 0.0686427418543975 no 3086 0.0891068407930799 936 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_229 benomyl 22.8748 µM -1.34790062997035 0.0684103905700927 no 3087 0.0888451727259743 987 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1119 parthenolide 318.541 nM -1.34943642738106 0.0681913686297589 no 3088 0.0885984134776649 1018 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_600 1495-0418 41.6 µM -1.35043319077996 0.0680495088696115 no 3089 0.0884385351721651 1005 5377768 SGTC_3054 9094397 49.47 µM -1.35279721402369 0.0677139711834836 no 3090 0.0880602115235636 1010 2598354 SGTC_2743 auranofin 4.32 µM -1.35308363186615 0.0676734054156164 no 3091 0.0880144570619844 985 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_3167 9103034 49.47 µM -1.35514602558729 0.0673818597443411 no 3092 0.0876855185901462 1016 5127859 SGTC_2167 5876490 200 µM -1.3552696499471 0.0673644147524044 no 3093 0.0876658304794222 993 686534 SGTC_2226 7298446 200 µM -1.35672272599226 0.0671596285615233 no 3094 0.0874346643311557 1012 3283010 SGTC_731 3966-0296 387 µM -1.35715758850034 0.0670984358173174 no 3095 0.0873655716999163 1009 660956 SGTC_3300 9124615 50.48 µM -1.35833114827068 0.0669335106652188 no 3096 0.0871793154193893 997 24824903 SGTC_3283 9109332 35.8195 µM -1.36012675438298 0.0666817739762963 no 3097 0.0868949079900233 973 17027281 SGTC_3275 9138069 49.47 µM -1.36025297301928 0.0666641062354698 no 3098 0.0868749422292201 1009 17617007 SGTC_2220 6782180 200 µM -1.36127555296204 0.0665211018246635 no 3099 0.0867133128579183 988 833803 SGTC_1397 3532-0190 20.1 µM -1.36253198407638 0.0663457193795471 no 3100 0.0865150287049889 998 5322280 SGTC_891 0929-0073 133 µM -1.36546001616679 0.0659383914724755 no 3101 0.0860542559118989 1018 5603632 SGTC_530 4358-1714 28 µM -1.36715277895063 0.0657037913951092 no 3102 0.085788711463466 982 1564641 SGTC_1803 st050068 52.4 µM -1.37114282553607 0.0651533710534468 no 3103 0.0851652185619786 990 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_3138 9097216 49.47 µM -1.37155457199706 0.0650967755848926 no 3104 0.0851010719920427 1002 25237486 SGTC_18 0111-0177 500 nM -1.37967633844858 0.0639882021583108 no 3105 0.0838431606848525 1019 721752 SGTC_2982 9019404 25.97 µM -1.38466560334758 0.0633145104401346 no 3106 0.0830773706871464 980 22333232 SGTC_1982 st072467 71.9 µM -1.3857660983923 0.0631666584826001 no 3107 0.0829091687213686 1000 3163533 SGTC_2021 4019055 173 µM -1.39045227886558 0.0625400764011847 no 3108 0.082195790398566 1003 44827708 YER133W GLC7 SGTC_3307 9126885 69.2785 µM -1.39371075925149 0.0621072534482656 no 3109 0.0817024829388167 1005 24824909 SGTC_1855 st056195 39.6 µM -1.39818274495934 0.0615170498121043 no 3110 0.0810290984927458 974 4028379 SGTC_2292 7671323 168.05 µM -1.40458289309828 0.0606800028717957 no 3111 0.0800726732536412 1010 937504 SGTC_1220 1838-0075 193 µM -1.40483001557218 0.0606478623390622 no 3112 0.0800359156385585 980 5529645 SGTC_3236 9132701 49.47 µM -1.40484578897501 0.0606458113162797 no 3113 0.0800335698963533 1027 24282524 SGTC_3189 9110682 49.47 µM -1.40640351785925 0.060443526240237 no 3114 0.0798021681345637 1034 17122418 SGTC_1069 diphenylcyclopropenone 8.49 µM -1.41362038293647 0.0595132329572475 no 3115 0.0787366966392286 1015 65057 A dermal irritant. YDR527W RBA50 SGTC_207 4185-0010 4.486 µM -1.41588838532834 0.0592232042323897 no 3116 0.0784040930303506 997 3761753 SGTC_575 k072-0246 11.9 µM -1.41790383303975 0.0589664030038943 no 3117 0.0781094215870292 1021 6796779 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.41807467381704 0.0589446753032881 no 3118 0.0780844822413937 983 6708630 An antioxidant. SGTC_2138 5575593 77.673 µM -1.4193941272191 0.0587770774391377 no 3119 0.0778920718143971 1005 762213 SGTC_1139 k015-0024 46.9 µM -1.41942146995945 0.0587736083052824 no 3120 0.0778880883444874 1011 2766652 SGTC_3318 9139014 38.6185 µM -1.42583075453691 0.0579648490296351 no 3121 0.0769586005972817 1006 16643984 SGTC_2243 6634756 200 µM -1.42616925282449 0.0579223798276871 no 3122 0.076909746292358 1006 885676 SGTC_2736 butenafine 14.65 µM -1.42742296797867 0.0577652972705565 no 3123 0.0767290072004951 1004 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1341 1486-1360 280 µM -1.43302720160065 0.0570672136593993 no 3124 0.0759250319116208 1022 3976547 SGTC_619 1652-1634 108 µM -1.43464465529598 0.0568669776321262 no 3125 0.0756941913539441 1026 5400454 SGTC_3177 9107506 49.47 µM -1.43473518286029 0.0568557869561489 no 3126 0.0756812872129439 1017 8897194 SGTC_2341 7987486 176.74 µM -1.4357742868688 0.056727461004892 no 3127 0.0755332893952967 1008 1258686 SGTC_1751 st044839 27.194 µM -1.44284908737771 0.0558598014295584 no 3128 0.0745314939034794 1007 5291326 SGTC_3078 9116413 49.47 µM -1.44523685357461 0.0555693384468098 no 3129 0.0741956839999541 995 17177322 SGTC_1872 amphotericin b 148 nM -1.44634813824815 0.055434561933955 no 3130 0.0740397901165959 998 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1263 0774-1208 64.8 µM -1.45160078659301 0.05480101091454 no 3131 0.0733063199607208 1018 906585 SGTC_1590 st077108 57.8 µM -1.45282811391702 0.0546538042362662 no 3132 0.0731357420224049 1006 5489485 SGTC_864 0469-0573 172 µM -1.4556744566665 0.0543136147977231 no 3133 0.0727413171651852 1042 689425 SGTC_3096 9117468 49.47 µM -1.45728282102289 0.0541221282295479 no 3134 0.0725191634420455 997 41316311 SGTC_1616 st002734 56.1 µM -1.45927797201427 0.0538853350442072 no 3135 0.0722443078588869 1018 4026101 SGTC_3240 9133527 49.47 µM -1.45995954271548 0.0538046315065442 no 3136 0.0721505966301157 1015 17617455 SGTC_3002 9075603 71.4286 µM -1.4652626581237 0.0531799646048098 no 3137 0.0714246351716392 997 20105405 SGTC_1281 0884-0031 11.8 µM -1.47054896557959 0.0525630136768746 no 3138 0.0707065671280576 1019 1548255 SGTC_269 exalamide 29 µM -1.47059907855118 0.0525571924227833 no 3139 0.0706997866515665 1029 3316 A derivative of salicylamide. SGTC_2881 9058953 51.95 µM -1.47271027207396 0.0523124151712622 no 3140 0.0704145878008564 992 17122249 SGTC_1952 st077036 64.1 µM -1.47354314374222 0.0522160992229366 no 3141 0.0703023196827145 1001 2937007 SGTC_1866 st057638 64 µM -1.47757650706404 0.0517516590535278 no 3142 0.0697605831703578 992 688802 SGTC_2223 6903751 107.57 µM -1.47948547548704 0.0515329899112693 no 3143 0.0695053052122578 1010 5598863 SGTC_694 1315-0438 43.2 µM -1.47984611861448 0.0514917614742882 no 3144 0.0694571588810397 1009 6793154 SGTC_2935 9038016 29.96 µM -1.48228815885476 0.0512132791088193 no 3145 0.0691318188249961 1003 6463195 SGTC_2141 5621638 7.665 µM -1.48273135673774 0.0511628669692696 no 3146 0.0690729000238429 1028 2856238 SGTC_865 0488-0499 301 µM -1.48528401261026 0.0508732799103209 no 3147 0.0687343025517476 1002 9634651 SGTC_107 0358-0022 2.6945 µM -1.48799667961337 0.0505669721075788 no 3148 0.0683758846451719 1041 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_3305 9127027 53.8275 µM -1.49162176158346 0.0501599321086552 no 3149 0.0678991650071485 1009 41905295 SGTC_1891 st059073 26.2 µM -1.49788108386032 0.0494632607838396 no 3150 0.0670820745808862 1030 688754 SGTC_1188 1403-0014 4.57 µM -1.49900483025221 0.0493390079098329 no 3151 0.0669361894905181 1000 9614867 SGTC_2752 diclazuril 33.15 µM -1.50360758946932 0.0488326784575306 no 3152 0.0663412179113897 1002 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_1465 k213-0056 144 µM -1.51210921536181 0.047908376322032 no 3153 0.0652530404443459 983 24048857 YMR208W ERG12 SGTC_2822 7994718 71.43 µM -1.51289816230611 0.0478233164614137 no 3154 0.0651527643956117 1052 1018011 SGTC_1923 st058458 19.1 µM -1.51404937777534 0.0476994158181146 no 3155 0.06500665820289 1018 3534982 SGTC_38 0929-0051 58.268 µM -1.51640166137552 0.0474470484076406 no 3156 0.0647089096172575 1022 1379719 SGTC_2753 fluvastatin 17.09 µM -1.51793518132062 0.0472830998194962 no 3157 0.064515369933644 1029 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1417 3966-0327 90.4 µM -1.51868482905073 0.0472031203808585 no 3158 0.0644209235537968 1030 651118 SGTC_925 2064-1272 59.6 µM -1.53137762891243 0.0458653248850529 no 3159 0.0628380448812534 1018 6815817 SGTC_1805 st050013 60.3 µM -1.53141799300967 0.045861119706027 no 3160 0.0628330599852221 1013 4037144 SGTC_2973 9094665 17.96 µM -1.53855444700522 0.0451224917980033 no 3161 0.0619565533367873 1008 25237061 YIL048W NEO1 SGTC_1364 1653-0028 37.6 µM -1.54023830921717 0.0449496141996631 no 3162 0.0617511375006115 1010 5718652 SGTC_2675 theaflavin digallate 100 µM -1.54189419186619 0.0447801295326093 no 3163 0.0615496537979732 1041 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2610 ononetin 44.17 µM -1.54410198415305 0.0445549560591515 no 3164 0.0612818141354168 1033 259632 SGTC_1128 3448-9350 235 µM -1.54971757435027 0.043986329030757 no 3165 0.0606046590413179 1015 619386 SGTC_827 3253-0474 693 µM -1.55157078712204 0.0437999647184529 no 3166 0.0603824787833095 1027 5402065 SGTC_2614 arthonioic acid 13.39 µM -1.56335893176903 0.0426293803249186 no 3167 0.0589840970506504 1030 6710684 SGTC_1320 1313-0481 95.3 µM -1.56501905049465 0.0424665784014451 no 3168 0.0587892212505296 1019 6813365 YLR208W SEC13 SGTC_1194 1488-0194 225 µM -1.56576054235717 0.0423940255756824 no 3169 0.0587023434030738 1033 1391452 SGTC_293 4049-0273 38.5 µM -1.56738172857049 0.0422357464548472 no 3170 0.0585127460829169 1015 1380311 SGTC_1994 st072947 40.9 µM -1.57053088566498 0.0419296555933106 no 3171 0.0581458274074007 1033 5286565 YDL195W SEC31 SGTC_2598 perillyl alcohol 100 µM -1.57055970369366 0.0419268628617033 no 3172 0.0581424780905743 1034 10819 An apoptosis inducer. SGTC_933 2914-0560 114 µM -1.57856031866505 0.0411573351659355 no 3173 0.0572184712389902 1017 463887 SGTC_3313 9133968 57.047 µM -1.58097227660717 0.0409276041740758 no 3174 0.0569421883854705 1006 1494643 SGTC_3312 9133330 71.43 µM -1.58173454604754 0.0408552172297601 no 3175 0.0568550913988193 1045 17617324 SGTC_1375 2910-0797 186 µM -1.58484901133135 0.0405605385324223 no 3176 0.0565003218552744 1030 742508 SGTC_396 dithiazanine 1.25 µM -1.58610904551115 0.040441810220468 no 3177 0.0563572876472575 1029 10578 An antihelmenthic. SGTC_2763 lisinopril 49.32 µM -1.5917003100958 0.03991836607751 no 3178 0.0557260293160868 1015 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2764 methyldopa 94.69 µM -1.59228161772988 0.0398642625514399 no 3179 0.0556607206995145 1035 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1644 st010134 20.9 µM -1.59668915201568 0.0394559806547126 no 3180 0.0551675074737459 1034 3818134 SGTC_2988 9073640 71.4286 µM -1.61367809282601 0.0379139635477153 no 3181 0.0532986340769893 1043 9102229 SGTC_2000 st075254 36.4 µM -1.61512187611626 0.0377852162720894 no 3182 0.0531421522027736 1022 17234175 SGTC_1472 k841-0093 193 µM -1.61561248485671 0.037741548262731 no 3183 0.0530890614446455 1039 X1472 SGTC_1935 st074532 41.6 µM -1.61827384705186 0.0375053835165031 no 3184 0.0528017971393233 1016 2829742 SGTC_1561 5-methoxyflavone 52.9 µM -1.61900713406659 0.0374405253604801 no 3185 0.0527228640777678 1011 94525 SGTC_2463 5473429 200 µM -1.61917511276227 0.0374256807951586 no 3186 0.0527047955686423 1032 5399405 SGTC_2785 7756463 72.73 µM -1.61931282127043 0.0374135148442574 no 3187 0.052689986716093 1035 2201551 SGTC_405 ebelactone b 50 µM -1.61964484859503 0.0373841949492778 no 3188 0.0526542948474265 1032 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_890 0929-0006 47.2 µM -1.62430654445327 0.0369745188546337 no 3189 0.0521552006040585 1035 1378169 SGTC_2055 5235184 200 µM -1.62559732424678 0.0368617344490344 no 3190 0.0520176724033661 1023 2836034 SGTC_604 1000-0114 314 µM -1.62602643177197 0.0368243027011453 no 3191 0.0519720163191842 1058 1572745 SGTC_813 k007-0158 173 µM -1.63253426262484 0.0362604146851759 no 3192 0.051283493377421 1040 6523916 SGTC_2496 diffractaic acid 79.83 µM -1.65269717866865 0.0345580745794432 no 3193 0.0491962544465293 1033 94870 An apoptosis inducer which activates caspases. SGTC_2698 st077697 67.5 µM -1.65648231490666 0.0342459348313096 no 3194 0.0488120917896765 1039 3154499 SGTC_1303 1160-0052 261 µM -1.66957637252553 0.0331839656463364 no 3195 0.0475016041764309 1031 3562476 SGTC_3111 9122088 49.47 µM -1.67477249309564 0.0327701317358307 no 3196 0.0469894388876906 1037 16876704 SGTC_1812 st052057 4.327 µM -1.67760527548962 0.0325463189157939 no 3197 0.046712091127792 1043 3645418 SGTC_558 k064-0027 21.3 µM -1.68051532624136 0.0323177156958655 no 3198 0.0464285474543581 1042 5088526 SGTC_3282 9108498 15.4605 µM -1.68078372495222 0.0322966981572236 no 3199 0.0464024655002853 1047 16459645 SGTC_786 4544-0069 423 µM -1.68150177776468 0.0322405249383826 no 3200 0.0463327457142238 1034 748821 YLR208W SEC13 SGTC_2041 5107442 45.335 µM -1.68173251293845 0.0322224916711011 no 3201 0.046310360201907 1045 793005 SGTC_1345 1488-0192 31.4 µM -1.68350880599781 0.0320839428333033 no 3202 0.04613831805507 1043 658348 SGTC_2671 danthron 100 µM -1.68489468446266 0.0319761877827433 no 3203 0.0460044461590744 1046 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1432 4049-0298 68.4 µM -1.70278356089072 0.0306119215692594 no 3204 0.0443042901912549 1057 741646 SGTC_986 1493-0483 84 µM -1.70748006481901 0.0302618499154357 no 3205 0.0438664300110609 1044 40079 SGTC_1424 4048-1941 275 µM -1.71272739578172 0.0298746514151075 no 3206 0.043381351319352 1044 X1424 SGTC_2520 obtusaquinone 4.71 µM -1.71466290784093 0.0297328721161146 no 3207 0.0432035239165015 1026 5967872 SGTC_2310 7668677 200 µM -1.71719343390189 0.0295483496487032 no 3208 0.0429719174349829 1039 2197143 SGTC_1530 rhein 70.4 µM -1.72120223061127 0.0292579800000241 no 3209 0.0426070666047062 1052 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_716 1683-5115 658 µM -1.72211205994383 0.0291924092582773 no 3210 0.042524610432444 1035 723597 SGTC_2027 5150920 200 µM -1.72238961317462 0.029172430513984 no 3211 0.0424994819932953 1009 786715 SGTC_652 0437-0092 114 µM -1.72675984506698 0.0288593485227605 no 3212 0.0421054014192904 1044 3091274 SGTC_3182 9108849 49.47 µM -1.7376212834329 0.0280933188783958 no 3213 0.0411387835408215 1039 17133045 SGTC_2968 9090663 33.37 µM -1.73891758675414 0.0280030352858966 no 3214 0.041024630137438 1017 25236811 SGTC_1916 st067606 49.2 µM -1.74676600209699 0.0274615630898694 no 3215 0.0403389680933773 1016 19590279 SGTC_1832 st054113 55 µM -1.75411855191543 0.026962248823395 no 3216 0.0397050977171731 1041 1251267 SGTC_1562 morin hydrate 59.1 µM -1.75788153628992 0.0267096491139732 no 3217 0.039383834025011 1038 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_1020 4335-0961 93.3 µM -1.78666288536471 0.0248422686545595 no 3218 0.036995995584611 1050 669075 SGTC_2020 4017018 200 µM -1.79258455744397 0.0244719630899818 no 3219 0.0365196887357887 1056 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2439 5492030 7.2 µM -1.79750002786386 0.0241681088866251 no 3220 0.0361281368541455 1021 5722370 SGTC_2269 7935389 174.42 µM -1.79971129368372 0.024032454521108 no 3221 0.0359531184455494 1042 97605 SGTC_1091 telmisartan 47.6 µM -1.80523680073296 0.0236962759169375 no 3222 0.035518817256204 1054 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_3301 9125354 19.7965 µM -1.80975421106582 0.0234243773008035 no 3223 0.0351669557795386 1052 41905162 SGTC_559 1550-0661 158 µM -1.81661444782413 0.0230164893078615 no 3224 0.0346380848146224 1060 5830875 SGTC_436 n,n-dimethylsphingosine 3.3 µM -1.82824216248412 0.0223388066023672 no 3225 0.0337566079094926 1046 5282309 SGTC_1332 1480-0653 17.5 µM -1.82850427890943 0.022323726113962 no 3226 0.0337369520412335 1052 5749438 SGTC_2402 5553605 200 µM -1.83407879994666 0.022005032001377 no 3227 0.0333211489361546 1059 6758546 SGTC_211 3455-0679 143.504 µM -1.84155329183322 0.0215837518833059 no 3228 0.032770259288285 1046 748649 SGTC_2533 agelasine 13.65 µM -1.84226991732659 0.0215437216334064 no 3229 0.0327178388940722 1042 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1046 2001-0062 216 µM -1.84320866700272 0.0214913786149548 no 3230 0.0326492749799317 1056 739778 SGTC_735 3076-0345 636 µM -1.847873051228 0.021232892121595 no 3231 0.0323103549355544 1053 2888990 SGTC_2834 9001755 58.44 µM -1.84943626178601 0.0211468539749304 no 3232 0.0321974217089791 1038 2989575 SGTC_286 k060-0067 22.9 µM -1.85323909391721 0.020938779135981 no 3233 0.0319240482897444 1061 5985051 SGTC_2951 9072950 58.06 µM -1.85450144325264 0.0208700929434785 no 3234 0.0318337269314896 1028 16488155 SGTC_1521 st012942 49.4 µM -1.85501021940345 0.0208424636998945 no 3235 0.0317973836254627 1050 24207259 SGTC_2432 5630864 12.22 µM -1.85795724050044 0.020683033281975 no 3236 0.0315875433656184 1056 5714970 SGTC_127 0180-0333 59.125 µM -1.86068970537221 0.0205361340862152 no 3237 0.0313940042370327 995 771601 SGTC_2838 9002687 71.43 µM -1.8629331405858 0.020416187157204 no 3238 0.031235836729728 1047 6457060 SGTC_1107 amlodipine 47 µM -1.87125753015435 0.0199762931884606 no 3239 0.0306546970525858 936 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_3263 9137018 49.47 µM -1.87836171361375 0.0196072645367386 no 3240 0.0301658496867975 1043 43844957 SGTC_861 0443-0273 110 µM -1.88751370983945 0.019140408110431 no 3241 0.0295456320532065 1056 6149169 SGTC_826 1683-5028 118 µM -1.89336883257225 0.0188467141401892 no 3242 0.029154418617991 1063 722377 SGTC_576 1073-0113 22.7 µM -1.90097585814166 0.0184708782995691 no 3243 0.0286525874239983 1055 5439563 SGTC_2137 5261020 140 µM -1.91462267449033 0.0178126255255361 no 3244 0.0277703206557037 1064 763655 SGTC_343 4130-2827 29.8 µM -1.93015725632023 0.0170877731413938 no 3245 0.0267936779450531 1072 1118244 SGTC_2761 levamisole 97.89 µM -1.93234546425948 0.016987724004786 no 3246 0.0266584402007696 1058 26879 An alkaline phosphatase inhibitor. SGTC_790 1575-0012 79.1 µM -1.93568375664331 0.0168360556960805 no 3247 0.0264532225400521 1034 378741 YLR208W SEC13 SGTC_1307 1187-1599 12.2 µM -1.94028295390652 0.0166289986962252 no 3248 0.0261726559169677 1063 1538471 SGTC_3294 9122953 26.2835 µM -1.95412665258742 0.0160188536696089 no 3249 0.0253431204011441 1062 16459826 SGTC_473 2-arachidonoylglycerol 10 µM -1.95544335725202 0.0159618336671278 no 3250 0.0252653814144447 1021 5282280 An endocannabinoid. SGTC_2361 9034121 116 µM -1.9559229477898 0.0159411082331745 no 3251 0.0252371158038919 1078 6496917 SGTC_3007 9078383 71.4286 µM -1.95641407796399 0.0159199080299811 no 3252 0.0252081975481279 1069 6496995 SGTC_1217 1183-1422 255 µM -1.96734352719972 0.015454341830234 no 3253 0.0245718100711911 1057 2849664 SGTC_1236 0330-0013 258 µM -1.9678717353245 0.0154321407432587 no 3254 0.0245413988400186 1067 4617066 SGTC_1972 st070201 17.4 µM -1.97186745062445 0.0152650823303991 no 3255 0.0243123699467101 1071 2829099 SGTC_1487 3970-0795 2.82 µM -1.97612697810506 0.0150887069610721 no 3256 0.0240701988061711 1065 3765103 SGTC_2158 5657123 3.6195 µM -1.98327149312055 0.0147968036095184 no 3257 0.0236685559186541 1072 2858827 SGTC_3000 9075062 71.4286 µM -1.996428514079 0.0142719420178807 no 3258 0.0229436498378872 1037 17057871 SGTC_1666 st014829 29 µM -1.99648181529071 0.0142698487624563 no 3259 0.0229407515971236 1076 3858230 SGTC_246 cycloheximide 667 µM -2.00530764066204 0.0139268664983265 no 3260 0.0224650842482822 1067 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1820 st053765 18.6 µM -2.00678089413221 0.0138703118442505 no 3261 0.0223864990458035 1059 3690829 SGTC_1687 st020778 55.3625 µM -2.01194729336731 0.0136735484046967 no 3262 0.022112746640845 1078 4259299 SGTC_1075 aripiprazole 15.2 µM -2.02279203307229 0.0132683448401333 no 3263 0.0215472967099012 1075 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2114 5491910 81.25 µM -2.03141798645977 0.0129534914127827 no 3264 0.0211063056869187 1069 2849228 SGTC_2084 5306078 60.6385 µM -2.03533568710928 0.0128126392303047 no 3265 0.0209085538327503 1079 679340 SGTC_2636 apigenin dimethyl ether 100 µM -2.03587039503079 0.0127935181275656 no 3266 0.0208816856633966 1060 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3322 9139058 2.11 µM -2.03943530699394 0.0126666670398229 no 3267 0.0207033008298062 1070 4908926 YPR165W RHO1 SGTC_2936 9038235 15.59 µM -2.04232450954828 0.0125646598534984 no 3268 0.0205596762259519 1048 4749415 SGTC_1668 st014914 51.6 µM -2.04539467242378 0.0124570437213901 no 3269 0.0204079818831057 1086 2839556 SGTC_42 0133-0086 60.653 µM -2.05809379688831 0.0120203465889946 no 3270 0.0197905651823816 1061 162923 Model of phenazepam hydroxylation. SGTC_485 niflumic acid 177 µM -2.05968601667023 0.0119665411586125 no 3271 0.0197142835335767 1083 4488 A COX2 inhibitor. SGTC_1421 4029-0249 71.4 µM -2.06327119943684 0.0118461522355679 no 3272 0.019543434398831 1070 2894095 SGTC_1998 st075797 76.8 µM -2.0651487919601 0.0117835237666731 no 3273 0.0194544620036533 1059 24208315 SGTC_1295 1013-0063 9.78 µM -2.07736439515585 0.0113830363846503 no 3274 0.0188839698882283 1067 6826038 SGTC_766 1391-0721 126 µM -2.09782176974402 0.0107388052370673 no 3275 0.0179604463436364 1077 1020919 YIL115C NUP159 SGTC_526 4469-0568 170 µM -2.1038483295016 0.0105551780546389 no 3276 0.0176958397196334 1063 2901964 SGTC_3212 9128307 49.47 µM -2.10555375018727 0.0105037136230105 no 3277 0.0176215668495667 1058 27243542 SGTC_1938 st074717 56.4 µM -2.10747583990974 0.0104459729876944 no 3278 0.0175381768848227 1046 17250979 SGTC_2818 7996756 12.99 µM -2.11148290794559 0.0103264873385291 no 3279 0.017365412755464 1079 2241621 SGTC_2176 5809774 33.9695 µM -2.11439592228983 0.0102403746514382 no 3280 0.0172407328262792 1050 2870539 SGTC_2469 5655019 90.81 µM -2.11838499342346 0.0101234686265457 no 3281 0.0170712378695309 1073 2788239 SGTC_791 1348-1292 225 µM -2.11920456015901 0.0100995946478051 no 3282 0.0170365915417141 1082 5437054 SGTC_1186 1319-0216 26 µM -2.11926940128125 0.0100977079247507 no 3283 0.0170338530185559 1077 4565136 SGTC_2700 st077718 96.8 µM -2.12294165300632 0.00999135480899989 no 3284 0.0168793707371606 1073 904970 SGTC_775 4577-0580 57.3 µM -2.12511964236423 0.00992874045969422 no 3285 0.0167883154856248 1069 2006902 SGTC_289 k017-0060 526 µM -2.12599633741872 0.00990363348944006 no 3286 0.0167517822499471 1078 5512909 SGTC_2322 7413319 38.22 µM -2.13258129335552 0.00971681774216911 no 3287 0.0164795446145081 1040 1840400 SGTC_853 0419-0306 21 µM -2.1375821187774 0.00957700805187094 no 3288 0.0162753371436113 1080 762713 SGTC_3011 9081274 71.4286 µM -2.13925280088971 0.00953069372840306 no 3289 0.016207600009551 1073 6625322 SGTC_2035 5154463 94.595 µM -2.16234880108626 0.00891021269594506 no 3290 0.0152956503957193 1067 2769623 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -2.16654530913961 0.00880135393810132 no 3291 0.0151347707270406 1064 4000243 SGTC_2064 5220758 200 µM -2.18705816873482 0.00828585388276079 no 3292 0.0143691389318185 1069 788518 SGTC_2874 9043904 71.43 µM -2.1882724812334 0.0082561863578888 no 3293 0.014324880085726 1060 4463428 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -2.20039310217518 0.00796513682569316 no 3294 0.0138895084025593 1079 2724278 An inhibitor of dopamine biosynthesis. SGTC_728 3030-5151 22.5 µM -2.21112394452682 0.00771502892123531 no 3295 0.0135136276229094 1087 3125388 SGTC_585 0kpi-0023 191 µM -2.21840549394737 0.00754927636306465 no 3296 0.0132635984345809 1068 64601 SGTC_561 1550-0330 72.9 µM -2.22759065550773 0.00734466994528122 no 3297 0.0129539121840262 1085 6812934 SGTC_1223 0764-0573 147 µM -2.23696416329906 0.0071409229201831 no 3298 0.0126443411737023 1076 1609797 SGTC_934 2950-0684 338 µM -2.24417124010431 0.00698767373475251 no 3299 0.0124106928566433 1068 1121253 SGTC_106 0092-0003 11.579 µM -2.25103917170306 0.00684434498748468 no 3300 0.0121915282421976 1074 1072148 SGTC_633 0437-0093 97.7 µM -2.2699720090475 0.00646258863172047 no 3301 0.0116046407092664 1077 2831118 SGTC_3317 9138495 8.753 µM -2.30743543492443 0.00576229872360389 no 3302 0.0105152788610275 1080 17020139 SGTC_3041 9091929 49.47 µM -2.32529990129134 0.00545273215521222 no 3303 0.0100279647881445 1072 25236887 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -2.32581151493156 0.00544408856804487 no 3304 0.010014304040701 1077 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1677 st019204 53.9 µM -2.33192666300132 0.0053417133735925 no 3305 0.00985227476962048 1083 3945625 SGTC_2323 6148992 148.28 µM -2.37096152644801 0.00472762515201351 no 3306 0.00887093889766458 1077 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1056 3448-1962 115 µM -2.37291921516663 0.00469855600474186 no 3307 0.00882406169490468 1069 715507 SGTC_1227 3909-8010 46.6 µM -2.37342482607403 0.00469107429121286 no 3308 0.00881199008735039 1073 15982272 SGTC_940 3232-1287 54.8 µM -2.38959893272305 0.00445727909817844 no 3309 0.00843339023153688 1076 1585493 YIL048W NEO1 SGTC_3123 9126162 49.47 µM -2.3900895483214 0.00445035286871689 no 3310 0.00842213261761455 1067 25239884 SGTC_1926 methyl fluorone black 53.6 µM -2.39870056070048 0.00433034269360118 no 3311 0.00822668167329462 1042 72721 Reacts with homocysteine. SGTC_1280 0880-0253 10.1 µM -2.40049354936883 0.00430572103138799 no 3312 0.00818648966229505 1076 6836607 SGTC_761 k216-0224 480 µM -2.40724688438863 0.00421410248584439 no 3313 0.00803664992923401 1087 1340404 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -2.40896377504708 0.00419109017777255 no 3314 0.00799894289755168 1066 279621 SGTC_1240 0356-0016 42.1 µM -2.43673839955872 0.00383411293157484 no 3315 0.00741019834205638 1038 4305613 SGTC_1788 fluconazole 20 µM -2.44649497641505 0.00371533794446074 no 3316 0.00721264038283111 1079 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1914 st062367 72.6 µM -2.44885809511963 0.00368707083863558 no 3317 0.00716549481859828 1076 978205 SGTC_247 mechlorethamine 29.705 µM -2.45338422678669 0.00363346832978082 no 3318 0.00707595430527434 1084 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2025 5147754 141 µM -2.47348572893371 0.0034037614223934 no 3319 0.00669010739776412 1068 315777 YLR208W SEC13 SGTC_1315 1237-0019 3.69 µM -2.48738184017529 0.00325268394048623 no 3320 0.00643435971189039 1079 825140 SGTC_2358 9037157 4 µM -2.48911393919347 0.00323428174198063 no 3321 0.00640309585830022 1073 2388925 SGTC_1338 1486-1223 76 µM -2.50545278866416 0.00306524870645008 no 3322 0.0061147361852969 1080 3444526 SGTC_855 0428-0020 25 µM -2.51671013918866 0.00295345981680251 no 3323 0.00592281189049042 1080 6812414 SGTC_1734 st037168 69.4 µM -2.52427402035404 0.0028804261057936 no 3324 0.00579687589769758 1080 708907 SGTC_2911 7942208 15.64 µM -2.58571824608939 0.00234490796125099 no 3325 0.0048588165104064 1070 1243384 SGTC_2237 6667747 47.222 µM -2.58876388389618 0.00232087507483841 no 3326 0.00481605573919505 1085 729940 YDL015C TSC13 SGTC_2908 7930301 100 µM -2.63474819670604 0.00198413233973797 no 3327 0.00420998601754307 1076 2223178 SGTC_2836 9010338 19.48 µM -2.67087993301517 0.00175137017130947 no 3328 0.00378263510620749 1085 2994051 SGTC_3040 9091894 49.47 µM -2.69769771208327 0.00159498601639227 no 3329 0.00349104049804306 1081 25236966 SGTC_1275 0867-0008 21.1 µM -2.72188284371179 0.00146498213308816 no 3330 0.00324555749799397 1092 3422836 SGTC_846 0335-0850 148 µM -2.78430579450244 0.00117287132634152 no 3331 0.00268212170382666 1089 6819598 SGTC_3033 9090887 49.47 µM -2.7896299420344 0.00115060800160918 no 3332 0.00263841583461319 1075 19325384 SGTC_2245 6637752 200 µM -2.81152086176975 0.00106307828945357 no 3333 0.00246539465467073 1088 681890 SGTC_1705 st027868 56.3335 µM -2.83602402949375 0.00097237367222396 yes 3334 0.00228395045151867 1086 292948 SGTC_412 gemfibrozil 100 µM -2.86232633211065 0.000882958347399167 yes 3335 0.00210271830525677 1088 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1488 4013-0813 75.9 µM -2.89329745773355 0.000787389743565897 yes 3336 0.00190610036932893 1095 2910057 SGTC_1331 1472-0049 76.2 µM -2.8976862629341 0.000774645352042615 yes 3337 0.00187963219238448 1086 24051409 SGTC_1021 4476-0760 85.3 µM -2.9239446768148 0.000702280675135954 yes 3338 0.00172813084246051 1093 746768 SGTC_1284 0929-0043 16 µM -3.0062687698424 0.000513865579466454 yes 3339 0.00132237558406635 1089 1239883 SGTC_2701 st077767 14.721 µM -3.04202334543137 0.000447634123093722 yes 3340 0.00117496834103425 1081 5721188 SGTC_1415 3966-0071 78.1 µM -3.13722455691518 0.00030788063205842 yes 3341 0.000852777223117229 1088 2893185 SGTC_1634 st006576 41 µM -3.15503634108534 0.000286741063004102 yes 3342 0.000802390574273735 1089 3915356 SGTC_1372 2752-0194 270 µM -3.22567125258644 0.000215518320865388 yes 3343 0.000628388116533153 1086 823334 SGTC_432 NS 1619 61.3 µM -3.23735358855552 0.000205467959274911 yes 3344 0.000603219140316878 1086 4552 A K+/calcium channel activator. SGTC_1291 0993-0025 5.79 µM -3.24499809625447 0.000199130163310249 yes 3345 0.000587257044317774 1086 4353356 SGTC_2965 9082772 38.63 µM -3.24875803818467 0.000196080378309035 yes 3346 0.00057955013463334 996 16459634 SGTC_353 1988-1175 58.3 µM -3.25475851562514 0.000191303498419603 yes 3347 0.000567444098252498 1068 2788357 SGTC_858 0438-0351 2.77 µM -3.28494330597969 0.00016888019714798 yes 3348 0.000510014471428331 1094 2799119 SGTC_2699 st077704 54.6 µM -3.34118215730307 0.000133515295802311 yes 3349 0.000417112357757034 1092 645852 SGTC_2903 5923464 63.88 µM -3.38653644952461 0.000110185507786074 yes 3350 0.000353904366323229 1088 2876576 SGTC_1737 st035557 69.7 µM -3.40815103885411 0.000100467686680849 yes 3351 0.000327023406971446 1084 5716916 SGTC_2455 5377712 9.75 µM -3.47558277076678 7.5072783595069e-05 yes 3352 0.000254872331375375 1093 2243908 SGTC_1264 0783-0040 158 µM -3.76855148980022 1.9959294542021e-05 yes 3353 8.20988089179478e-05 1091 2855798 SGTC_2246 7293507 91.5585 µM -4.20149793804872 2.36308248900152e-06 yes 3354 1.32577331441636e-05 1094 887656 SGTC_2563 tomatine 8.54 µM -4.3878942611427 8.83683330190853e-07 yes 3355 5.72266962008193e-06 1092 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_758 0868-0029 16 µM -5.67663235987598 3.34315027250552e-10 yes 3356 6.86861350164716e-09 1089 762687