SGTCid condition conc unit YBR197C|YBR197C.score YBR197C|YBR197C.strain.pval YBR197C|YBR197C.strain.significant YBR197C|YBR197C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_188 3229-0966 278.469 µM 7.9724519139165 4.10741200738517e-16 yes 1 7.77783851995381e-16 5 5722370
SGTC_996 3970-0799 1.8 µM 5.98650994946473 7.58314341005954e-10 yes 2 1.07195740026212e-09 35 6615648 YGL040C HEM2
SGTC_1854 st056233 32.9 µM 5.73279561891478 3.60396517752311e-09 yes 3 4.93943231997598e-09 4 5393174
SGTC_8 0354-0001 70 µM 5.266630187781 5.34528718093111e-08 yes 4 6.9475359313906e-08 36 4993152
SGTC_46 0329-0187a 2.197 µM 5.21642011516304 7.05542805019215e-08 yes 5 9.12070959308588e-08 36 46494817
SGTC_129 0088-0017 176.636 µM 5.02322867901649 2.00559627673423e-07 yes 6 2.54049929313993e-07 47 182446
SGTC_696 1560-0013 611 µM 4.77235298072092 7.37044451682792e-07 yes 7 9.10430091894807e-07 12 1650269
SGTC_213 1246-0773 967 nM 4.53152557105674 2.42505126834674e-06 yes 8 2.92796235190143e-06 14 6251622
SGTC_697 0508-1955 564 µM 4.51056450033131 2.68265937314741e-06 yes 9 3.23276688939126e-06 23 6243113
SGTC_56 0957-0365 83.25 µM 4.17022567225666 1.30086570393743e-05 yes 10 1.52149078183854e-05 42 6752360
SGTC_140 0062-0056 502.533 µM 4.07470024348918 1.98529417112965e-05 yes 11 2.30368271886179e-05 20 3758964
SGTC_1984 st072354 53.1 µM 4.07458639901067 1.98628405661287e-05 yes 12 2.30480988411678e-05 14 5762938
SGTC_568 1193-0097 7.48 µM 4.05782300584022 2.13726799082498e-05 yes 13 2.47661417707796e-05 142 3646150
SGTC_1257 0669-0121 16 µM 3.94465964208773 3.47961793595901e-05 yes 14 3.99567006001696e-05 28 4307855
SGTC_1750 st081859 2.357 µM 3.91279064751767 3.98257548607767e-05 yes 15 4.56178131884176e-05 189 5291695
SGTC_87 0100-0052 35.5 µM 3.82730688203036 5.69266732908066e-05 yes 16 6.47764774951488e-05 118 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_955 1216-0110 33 µM 3.80840667837641 6.15464021730957e-05 yes 17 6.99325559477232e-05 71 3619719
SGTC_1778 st046819 58.9 µM 3.76851442842471 7.24823092266973e-05 yes 18 8.21109971603632e-05 31 671715
SGTC_2966 9084041 48.03 µM 3.60586172549596 0.000138962953362924 yes 19 0.000155559389145339 44 17741380
SGTC_1324 1418-0026 34.4 µM 3.55595209417296 0.000168812191696347 yes 20 0.000188306352556834 22 1372513
SGTC_2305 7443522 69.23 µM 3.54027920106685 0.000179359622417894 yes 21 0.000199851967403037 25 5415886
SGTC_1828 st055811 49 µM 3.52031787091064 0.000193686024880075 yes 22 0.000215514949182127 13 5877589
SGTC_396 dithiazanine 1.25 µM 3.44855064389986 0.000254511283847112 yes 23 0.00028180188420349 15 10578 An antihelmenthic.
SGTC_1787 fluconazole 80 µM 3.35859014531596 0.000355908863024594 yes 24 0.000391705824018655 58 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_998 3996-0085 177 µM 3.35210353350985 0.000364509509080959 yes 25 0.000401000101206205 43 715391
SGTC_802 4112-3352 742 µM 3.28278089246739 0.000469285861133088 yes 26 0.00051394262102062 45 704594
SGTC_1499 4480-0877 67.3 µM 3.22877332148289 0.000569555673139419 yes 27 0.000621611974281464 20 2861909
SGTC_261 5-fluorouridine 15.376 µM 3.09848252994296 0.000898314407507451 yes 28 0.000972572189673019 49 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_61 0978-8327 98.565 µM 3.03787639515268 0.00110428380924002 no 29 0.00119125828911796 69 6150059 YHR072W ERG7
SGTC_811 0416-0114 265 µM 3.02240938258005 0.00116336766552994 no 30 0.00125385575959062 69 6612453
SGTC_2722 naftopidil 47.16 µM 3.01700060318156 0.00118470303895066 no 31 0.00127644651947157 37 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2150 5556613 200 µM 3.00899302209732 0.00121694792496244 no 32 0.00131057567979075 57 743190
SGTC_285 1486-1325 46 µM 2.97598158552143 0.00135853605774981 no 33 0.00146026198996442 55 22310230
SGTC_1220 1838-0075 193 µM 2.95586952817657 0.0014520181134249 no 34 0.00155894476804495 51 5529645
SGTC_2239 6685329 187.64 µM 2.91399234041925 0.00166576576044906 no 35 0.00178419330896834 88 805680
SGTC_1064 honokiol 6.76 µM 2.88549787441201 0.0018271869740009 no 36 0.00195397550340329 74 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1251 0490-5699 265 µM 2.86268289142178 0.00196654886565646 no 37 0.00210035373623066 96 3883818
SGTC_2858 9025781 8.96 µM 2.86232815086826 0.00196878997919926 no 38 0.00210270623780653 179 4894980 YPL153C RAD53
SGTC_754 3474-0146 171 µM 2.80361039599646 0.00237335401207371 no 39 0.00252669644044208 84 24762078
SGTC_450 aminopyrene 156 nM 2.79741214529134 0.00242017920606362 no 40 0.00257568873926779 102 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_59 0330-0160 1.33 µM 2.77492395556628 0.00259716855855778 no 41 0.00276073082824646 226 4293482
SGTC_2592 piperlongumine 83.33 µM 2.77171866829256 0.00262332584647755 no 42 0.00278806030296828 91 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2777 climbazole 1.536 µM 2.75754861242035 0.00274183770051154 no 43 0.00291182767075481 120 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_155 k072-0202 43.6 µM 2.74609002219487 0.00284118278392664 no 44 0.00301551061310672 70 5857737
SGTC_2076 5212012 200 µM 2.7424675419821 0.00287325818982571 no 45 0.00304897380993228 29 604802
SGTC_2583 asiatic acid 100 µM 2.73359376388529 0.00295321550865797 no 46 0.00313236417534541 91 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2211 7117706 200 µM 2.73141029570386 0.00297319462018505 no 47 0.00315319531321967 63 822771
SGTC_1832 st054113 55 µM 2.7214316708516 0.00306605978117072 no 48 0.00324999105836244 43 1251267
SGTC_349 k015-0014 24 µM 2.71699232042759 0.00310820745856961 no 49 0.00329390681261841 101 2196908
SGTC_1906 st060206 94.7 µM 2.70179929076379 0.00325642796049186 no 50 0.00344826899295082 93 5133468
SGTC_17 0960-0276 49.807 µM 2.68381663829321 0.00344005848477313 no 51 0.00363935070461853 131 6821114
SGTC_2270 7924575 90.91 µM 2.67872483422501 0.00349371701143369 no 52 0.00369515491117236 90 1262135
SGTC_1784 st039334 36.3 µM 2.67291609820546 0.00355584770142893 no 53 0.00375975274104869 97 3496984
SGTC_409 arachidonic acid 100 µM 2.65595175059091 0.00374301808578729 no 54 0.00395424643767376 76 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_398 bronopol 33.3 µM 2.64707367158638 0.00384445213638807 no 55 0.0040595831420173 98 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2386 9075165 157.42 µM 2.62328711222468 0.00412846840001422 no 56 0.00435429251992255 52 16452277
SGTC_1376 2910-0861 41.3 µM 2.60392281506485 0.0043733923596433 no 57 0.00460817548913005 113 1112859
SGTC_1845 st056753 3.01 µM 2.59873665456436 0.00444115517355723 no 58 0.0046783762148899 110 5375839
SGTC_1217 1183-1422 255 µM 2.58872130285039 0.0045746763629241 no 59 0.00481665125734012 87 2849664
SGTC_2909 7941780 10.49 µM 2.58044267609226 0.00468773701621061 no 60 0.00493368684305685 105 1243215
SGTC_2220 6782180 200 µM 2.57878635169413 0.0047106543141448 no 61 0.00495740433425932 43 833803
SGTC_2347 9049783 174.81 µM 2.55798446603088 0.00500710123214874 no 62 0.00526403975368916 138 6467988 YPL169C MEX67
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 2.54700945349986 0.00517010767687799 no 63 0.00543252449020221 101 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_307 1501-1223 22.3 µM 2.53950524838272 0.00528426586619683 no 64 0.00555046898670908 84 2830329
SGTC_1262 0737-0114 49.6 µM 2.53904589208487 0.00529132612233987 no 65 0.00555776207770351 122 765919
SGTC_1375 2910-0797 186 µM 2.51519103574519 0.00566970083252228 no 66 0.00594839503968063 108 742508
SGTC_749 1000-0129 128 µM 2.50269941044548 0.00587726633847919 no 67 0.00616250860385376 113 708470
SGTC_953 1188-0045 9.7 µM 2.49866916978185 0.00594565782333459 no 68 0.00623303135958005 128 6144426
SGTC_2107 5363541 170.161 µM 2.48964840065852 0.00610129967398801 no 69 0.00639347617006082 96 244052
SGTC_1996 st072960 66.8 µM 2.48011426307749 0.00626971304944278 no 70 0.00656701432961544 101 1719405
SGTC_2507 purpurin 79.67 µM 2.46492116926849 0.00654660075661784 no 71 0.00685216992098856 147 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1090 efavirenz 20.7 µM 2.45910945456097 0.00665534310989518 no 72 0.00696410732571138 113 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2284 7945075 39.21 µM 2.45398398488838 0.00675256702216525 no 73 0.00706416367576636 140 1245402
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 2.44933833734449 0.00684177132539699 no 74 0.00715594701545961 101 756377
SGTC_2843 9000894 45.46 µM 2.43888764825406 0.00704625619590834 no 75 0.00736627394688428 59 2242070
SGTC_3219 9131112 49.47 µM 2.43734283941516 0.00707693607537342 no 76 0.00739782208079346 129 17612988 YMR079W SEC14
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 2.43483869795609 0.0071269187261419 no 77 0.00744921471523119 129 75037 A free radical scavenger.
SGTC_298 1391-0729 10 µM 2.4341601841836 0.00714051537143121 no 78 0.00746319394408373 98 3237558
SGTC_366 0181-0206 4.31 µM 2.42738124580335 0.00727761898526225 no 79 0.00760413242910569 183 274874
SGTC_362 0310-0100 9.03 µM 2.4118053721887 0.00760146670802492 no 80 0.0079368763140898 158 790235
SGTC_762 1165-0429 115 µM 2.40981604238336 0.00764372873804319 no 81 0.00798028290122254 124 5967793
SGTC_2861 9024595 19.48 µM 2.40212142722351 0.00780914965139342 no 82 0.00815014833152388 36 16482810
SGTC_2736 butenafine 14.65 µM 2.39064840035841 0.00806164918190806 no 83 0.00840932532995605 159 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1682 st012968 530 nM 2.37604914222772 0.0083933083153188 no 84 0.0087495660413094 125 24207270
SGTC_2839 9003951 25.97 µM 2.32134222538993 0.00974500651472874 no 85 0.0101341905006672 109 2990634
SGTC_1222 0366-0074 1.18 µM 2.31785894064123 0.00983717659696533 no 86 0.0102284942803128 137 286520
SGTC_1125 tnp00248 1.32998 µM 2.31214875511925 0.0099899194152444 no 87 0.0103847435749365 213 24207736
SGTC_438 sphingosine 6.67 µM 2.30628075820314 0.0101490363280731 no 88 0.0105474747977816 123 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_2978 9011784 42.97 µM 2.30515265899093 0.0101798780368148 no 89 0.0105790125814256 207 2994934
SGTC_2055 5235184 200 µM 2.30432314356583 0.010202608735529 no 90 0.0106022553696205 164 2836034
SGTC_110 0850-0284 111.64 µM 2.3039914883921 0.010211709258737 no 91 0.0106115606945929 75 3906265
SGTC_1379 2144-0755 36.5 µM 2.29972369578865 0.0103294495477818 no 92 0.0107319393889159 165 5392327
SGTC_761 k216-0224 480 µM 2.29644790005494 0.0104206237520143 no 93 0.0108251424256714 152 1340404
SGTC_3048 9093155 49.47 µM 2.28672139554995 0.010695484148459 no 94 0.0111060450249166 95 25236002
SGTC_2065 5221596 34.26 µM 2.27945802828331 0.0109048362532836 no 95 0.0113199261181301 145 788581
SGTC_1330 1469-0054 61.8 µM 2.2790648428692 0.0109162700903679 no 96 0.0113316055161912 137 7102664
SGTC_1679 SEC14.276 6.7 µM 2.26540283207111 0.0113200936716543 no 97 0.0117439853545105 219 1005053 YMR079W SEC14
SGTC_259 usnic acid 108.925 µM 2.26497926882624 0.0113328182048477 no 98 0.0117569758645205 162 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 2.26452297799383 0.0113465398340536 no 99 0.0117709840673397 177 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2417 cerulenin 830 nM 2.26187275231794 0.011426523509312 no 100 0.0118526331399122 148 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1776 st049249 45.9 µM 2.25832047318621 0.0115344991055288 no 101 0.0119628433962531 182 1822314
SGTC_486 niguldipine 82 µM 2.22161122573467 0.012703220278166 no 102 0.0131547952874198 122 1236 A calcium channel blocker.
SGTC_2231 micatex 6.853 µM 2.21542826742213 0.0129098338442922 no 103 0.0133653414456398 121 20737 An antifungal of unknown mechanism.
SGTC_2763 lisinopril 49.32 µM 2.21480702305275 0.0129307535098979 no 104 0.0133866564861871 112 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_2967 9089538 49.85 µM 2.21308917876533 0.0129887525360576 no 105 0.0134457490038815 194 728216
SGTC_384 k007-0144 5.16 µM 2.19061687138311 0.0137684403665173 no 106 0.014239764605679 229 6824886
SGTC_1777 st045864 34.765 µM 2.18318859685665 0.0140348954834474 no 107 0.014510962084381 144 4691462
SGTC_1333 1482-0047 286 µM 2.17776041181531 0.0142324064137007 no 108 0.0147119393217452 193 3811116
SGTC_1439 4092-1168 46 µM 2.14069958662809 0.0156459557944113 no 109 0.0161491359401814 149 2886240
SGTC_1720 st037298 9.481 µM 2.13597793756725 0.0158344202409557 no 110 0.0163406060763284 203 597396
SGTC_2770 toltrazuril 17.5 µM 2.12988408696941 0.0160805310595645 no 111 0.0165905921097912 197 68591 Kills coccidiodes.
SGTC_109 0132-0036 33.701 µM 2.127218271424 0.016189221120334 no 112 0.0167009758410964 111 67274 A color developer.
SGTC_1940 st075990 51.1 µM 2.1246737303761 0.0162935530948026 no 113 0.0168069234583229 215 1084979
SGTC_3329 9141233 27.5565 µM 2.1242313901219 0.0163117486850084 no 114 0.0168253998085258 169 4909101 YNL103W MET4
SGTC_1266 0828-0227 32.9 µM 2.12242997923927 0.0163860292676135 no 115 0.0169008234522782 182 3913820
SGTC_1741 st038134 10.228 µM 2.11263157836433 0.0167951550201215 no 116 0.0173161568556928 236 1272587
SGTC_1853 st056710 91.2 µM 2.11118110318528 0.0168564549749596 no 117 0.0173783742160011 188 269167
SGTC_2034 5197015 53.07 µM 2.10583815722215 0.0170839116938592 no 118 0.0176092065438371 178 780676
SGTC_637 1181-0519 7.26 µM 2.10543683801729 0.0171011018375134 no 119 0.0176266499897706 309 6252091 YGR060W ERG25
SGTC_2925 9010536 32.5 µM 2.1041107191388 0.0171580101052371 no 120 0.0176843950152796 271 2994177
SGTC_1246 0422-0085 105 µM 2.09676447783919 0.0174762019186987 no 121 0.0180072147787878 239 264295
SGTC_1980 st071811 45.7 µM 2.08472557753476 0.0180085416343662 no 122 0.0185471087753557 180 4974850
SGTC_1988 st071872 53.4 µM 2.06940575641337 0.0187058956538415 no 123 0.0192540133965831 153 16414116
SGTC_2831 7999036 19.48 µM 2.06764286382078 0.0187875974100617 no 124 0.0193368091471193 251 2988270
SGTC_425 3825-7017 13.1 µM 2.06473641720051 0.0189229604716689 no 125 0.0194739734260178 227 3397440
SGTC_2810 7959871 45.46 µM 2.06040040413234 0.0191264448343625 no 126 0.0196801391537067 261 2974535
SGTC_2208 7283366 200 µM 2.05582988838243 0.0193429451338069 no 127 0.0198994580106543 180 898663
SGTC_1489 4065-0444 182 µM 2.0528684937991 0.0194843320363731 no 128 0.0200426666987088 186 2877968
SGTC_1401 3807-4679 7.6 µM 2.05138073369358 0.0195556933573904 no 129 0.0201149418969499 178 3291456
SGTC_2182 6325192 200 µM 2.03316276133445 0.0204476808578232 no 130 0.0210180409566957 173 736248
SGTC_248 streptozotocin 5.23457 mM 2.029559762988 0.0206281150840525 no 131 0.0212006542053221 222 5300 DNA alkylating agent.
SGTC_560 2332-1943 155 µM 2.02929770279873 0.0206412912226006 no 132 0.0212139885790522 171 21177716
SGTC_1860 st056228 74.6 µM 2.02928847835219 0.0206417551488993 no 133 0.0212144580745526 203 688679
SGTC_1080 nisoldipine 24.4 µM 2.02150438833336 0.0210364024298974 no 134 0.0216137892679252 224 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2497 7-hydroxyflavone 100 µM 2.02019840816725 0.0211032361310084 no 135 0.0216814056723097 203 5281894
SGTC_2729 fluphenazine 10.66 µM 2.01609366889088 0.0213144674585463 no 136 0.0218950909812706 218 3372 An atypical antipsychotic.
SGTC_1717 st033143 58.0435 µM 2.0133978476573 0.021454165858558 no 137 0.0220363959311009 262 674616
SGTC_2025 5147754 141 µM 2.01227362626267 0.0215126516774195 no 138 0.0220955504956724 165 315777 YLR208W SEC13
SGTC_2179 6298986 200 µM 1.99532010134379 0.0224110975972211 no 139 0.0230039894494405 185 738374
SGTC_2752 diclazuril 33.15 µM 1.98077400591768 0.0232069936674068 no 140 0.0238083115664238 389 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2764 methyldopa 94.69 µM 1.97738129636615 0.0233960112811737 no 141 0.0239992732598421 235 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_174 3553-0389 74.3 µM 1.97205898529363 0.0236951418759415 no 142 0.0243014366723038 200 738071
SGTC_2899 9053889 58.44 µM 1.95792665323784 0.0245050673405889 no 143 0.0251193099372032 176 6470052
SGTC_930 2810-3379 265 µM 1.95565489623206 0.0246374053656671 no 144 0.0252529106811481 251 1015764
SGTC_208 k072-0098 12.366 µM 1.95477647854743 0.0246887368746747 no 145 0.025304729302425 303 5948901
SGTC_1448 4255-0083 152 µM 1.953203479122 0.0247808813944782 no 146 0.0253977444983103 216 5399660
SGTC_517 1365-0151 113 µM 1.95207601908701 0.0248471040567808 no 147 0.0254645899488146 236 768657
SGTC_1952 st077036 64.1 µM 1.95057066284193 0.0249357542050444 no 148 0.0255540699543309 241 2937007
SGTC_542 3381-0244 89.3 µM 1.93971691390297 0.0255828104186639 no 149 0.0262070514390982 265 1112843
SGTC_44 0929-0055 61.211 µM 1.93759858260652 0.0257107225214441 no 150 0.0263361077701033 218 1379590
SGTC_2636 apigenin dimethyl ether 100 µM 1.93713683038923 0.0257386756511468 no 151 0.026364309775737 296 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.93125556307968 0.0260969410967076 no 152 0.0267257278902644 325 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_443 clozapine 122 µM 1.92992446966363 0.0261786026679909 no 153 0.0268080985055961 158 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3340 9146634 11.102 µM 1.9274516459046 0.026330875720852 no 154 0.0269616843022251 222 4907387
SGTC_2730 imipramine 71.33 µM 1.92650625238456 0.0263892870430568 no 155 0.0270205959541563 309 3696 A tricyclic antidepressant.
SGTC_957 1187-1561 14.1 µM 1.92607829821169 0.0264157638602103 no 156 0.0270472989734095 263 1538454
SGTC_1941 st076221 61.8 µM 1.92300251997316 0.0266067110665166 no 157 0.0272398666913575 321 2828568
SGTC_1082 camptothecin 424.86 nM 1.91830474730301 0.0269005777160323 no 158 0.027536190417044 256 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_669 0108-0021 26.2 µM 1.91330354015912 0.027216398337037 no 159 0.0278546023980935 390 17201
SGTC_122 0236-0016 402.397 µM 1.90715550921717 0.0276088721981298 no 160 0.0282502264346818 305 6808838
SGTC_798 1287-0182 476 µM 1.90536169461292 0.0277242695985561 no 161 0.0283665354514067 284 1649755
SGTC_2644 guaiazulene 100 µM 1.89981852461716 0.0280834085383491 no 162 0.0287284695241777 196 3515 A coloring agent.
SGTC_470 aa-861 153 µM 1.89749973689977 0.0282347864755576 no 163 0.0288810067386274 306 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1477 0139-0234 16 µM 1.89611900568462 0.0283252472601865 no 164 0.0289721549867775 223 620880
SGTC_1300 1094-0077 113 µM 1.8851588228771 0.0290519110610936 no 165 0.02970419914714 228 5532636
SGTC_2427 5545055 42.75 µM 1.88325785060323 0.0291795091482646 no 166 0.0298327162613559 275 5372858
SGTC_1971 st069429 63.5 µM 1.86841963398167 0.0301915703846967 no 167 0.0308518012313847 213 1246522 YGL099W LSG1
SGTC_3185 9108267 49.47 µM 1.8624856844468 0.030604367808963 no 168 0.0312673307227259 282 4910486
SGTC_2612 dictamnine 15.46 µM 1.85305635796706 0.0312699304286141 no 169 0.0319371406050294 284 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1691 st019933 84.6 µM 1.85053821482449 0.0314496833180964 no 170 0.0321180077171358 230 6176082
SGTC_2624 nerol 100 µM 1.85028072288639 0.031468111938687 no 171 0.0321365497886037 218 637566 A natural product oil.
SGTC_3261 9137475 49.47 µM 1.84581958323637 0.0317888140280105 no 172 0.0324592030733372 97 17027690
SGTC_3263 9137018 49.47 µM 1.84504424129065 0.0318448262391334 no 173 0.0325155516064246 270 43844957
SGTC_1895 st058434 18.3 µM 1.84069652541408 0.032160425938017 no 174 0.0328330217028636 268 5393175
SGTC_1164 k060-0068 93.7 µM 1.83912309832915 0.0322752750587018 no 175 0.0329485411663674 296 5963676
SGTC_2550 chrysin dimethyl ether 71.87 µM 1.82820761709085 0.0330813805327815 no 176 0.0337591991391893 168 88881 An O-methylated flavonoid and antioxidant.
SGTC_1121 fusaric acid 630.51 nM 1.82620861118371 0.0332307889334559 no 177 0.0339094223709501 296 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_454 lyso-paf C-16 6.67 µM 1.82061308423195 0.0336519637909214 no 178 0.0343328462429881 274 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1624 st003710 6.25 µM 1.82005985831099 0.0336938426490183 no 179 0.034374944886396 334 24207033
SGTC_2786 7743617 45.45 µM 1.82003265534016 0.0336959030027495 no 180 0.0343770160352744 230 583674
SGTC_2480 5767542 37.17 µM 1.81492239346353 0.0340847975009931 no 181 0.0347679183236373 238 2867358
SGTC_1534 6-azauridine 81.6 µM 1.81335448136522 0.034204853928673 no 182 0.0348885826714577 326 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3034 9090421 49.47 µM 1.80733411671767 0.0346690727221746 no 183 0.0353550998176819 229 17173761
SGTC_3257 9139206 32.98 µM 1.80515099738037 0.0348386820257097 no 184 0.035525528317072 190 4910041
SGTC_1163 k060-0048 49.9 µM 1.80118693547803 0.0351483963080002 no 185 0.035836710423368 317 6809982
SGTC_411 enrofloxacin 100 µM 1.78714760462101 0.0362635136535244 no 186 0.0369568175526198 261 71188 A bacterial gyrase inhibitor.
SGTC_2641 levomentholum 100 µM 1.77318421439382 0.0374011617185729 no 187 0.0380990934523805 203 16666
SGTC_1361 1608-0041 5.61 µM 1.76420878554233 0.0381476944150854 no 188 0.0388484170660374 300 X1361
SGTC_3160 9100216 49.47 µM 1.76334412181928 0.0382202502729077 no 189 0.03892123399837 255 17191039
SGTC_386 1509-0011 3.07 µM 1.76287958167062 0.0382592773169893 no 190 0.0389604007327411 425 3107280
SGTC_1403 3909-7815 62.9 µM 1.76053612007726 0.03845665242451 no 191 0.0391584744163462 238 6615483
SGTC_3058 9093861 49.47 µM 1.74734168917768 0.0395834815049976 no 192 0.0402890428289519 309 17217477
SGTC_801 0866-0028 10.1 µM 1.73828056183277 0.0403727612509926 no 193 0.0410806948670006 350 6849771
SGTC_43 0570-0105 72.5 µM 1.73625292087863 0.0405511197100092 no 194 0.0412595618203191 462 1114046 YDL195W SEC31
SGTC_225 nsc-122657 1.016 µM 1.7341650177955 0.0407354469250773 no 195 0.0414444039818921 184 275685
SGTC_444 curcumin 90.4 µM 1.73125755295688 0.0409932598585471 no 196 0.0417029192518983 320 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1656 st012921 11 µM 1.73065258755753 0.0410470697929729 no 197 0.0417568731549521 260 6732821
SGTC_701 4424-0219 185 µM 1.72631316437154 0.0414347301680538 no 198 0.042145544148916 318 2911779
SGTC_2372 9071633 200 µM 1.72328141034025 0.0417073270150774 no 199 0.0424188239003805 318 21321366
SGTC_1880 MG-132 525 µM 1.71758389978349 0.042223541508709 no 200 0.0429362695379067 276 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1240 0356-0016 42.1 µM 1.71679521714957 0.042295404550851 no 201 0.043008297580885 324 4305613
SGTC_1359 1582-0056 520 nM 1.7146068986499 0.0424953176533402 no 202 0.0432086615411606 349 3661189
SGTC_2917 7979103 53.79 µM 1.71216698178769 0.0427191157281312 no 203 0.0434329501799365 371 2980565
SGTC_2045 5106652 78.05 µM 1.70959386930325 0.0429561622132298 no 204 0.0436705000573837 295 673349
SGTC_966 1300-0360 30.2 µM 1.70154152179899 0.0437048544342939 no 205 0.0444206739117225 330 70588
SGTC_1572 epiandrosterone 68.9 µM 1.69433528564463 0.0443837715578224 no 206 0.0451007945504703 340 441302 A steroid.
SGTC_1239 0337-0584 35.4 µM 1.679980679602 0.0457614711935473 no 207 0.0464805374263857 416 914301 YML130C ERO1
SGTC_2226 7298446 200 µM 1.67894593429297 0.0458620956708519 no 208 0.046581290594487 277 3283010
SGTC_408 cantharidin 100 µM 1.67482044658514 0.046265050252416 no 209 0.0469847329670267 376 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_747 3448-8087 38.7 µM 1.67085182538875 0.0466553610103838 no 210 0.0473754744942541 361 5168703
SGTC_81 0411-0046 9.971 µM 1.65747139018778 0.0479908216580521 no 211 0.0487121042234865 308 12925265
SGTC_1469 k284-2957 126 µM 1.65211033897573 0.0485344038829799 no 212 0.0492560298395025 307 23884841
SGTC_1686 st019653 115.5 µM 1.65046875721054 0.0487018325949747 no 213 0.0494235491484343 318 97252
SGTC_3164 9100705 49.47 µM 1.64522265412539 0.0492399918241412 no 214 0.049961951695712 259 17174235
SGTC_2508 celastrol 40.54 µM 1.64222795969232 0.0495493182258756 no 215 0.0502713851752104 301 122724 Celastrol is a natural product and antioxidant.
SGTC_2595 hexamethylquercetagetin 100 µM 1.63449354138851 0.0503553955442791 no 216 0.0510776306435181 336 386331
SGTC_200 k038-0079 37.545 µM 1.62781420026471 0.051059891529604 no 217 0.0517821442931973 342 3436683
SGTC_1670 st016595 4.04 µM 1.62729445458925 0.051115038432962 no 218 0.0518372875543651 357 597879
SGTC_3178 9107506 49.47 µM 1.62504224371269 0.0513545540924082 no 219 0.0520767789977011 355 8897194
SGTC_3152 9099253 49.47 µM 1.62336878735811 0.0515330984347994 no 220 0.0522552964412794 496 25236131
SGTC_2907 7721985 69.9 µM 1.61604715137407 0.0523200693159308 no 221 0.053042059565194 371 3267881
SGTC_2338 7999974 200 µM 1.61253364405641 0.0527010944427501 no 222 0.0534229324188946 378 315925
SGTC_1198 1612-1005 86.7 µM 1.60783305497307 0.0532142931344081 no 223 0.0539358734247863 371 6998509
SGTC_2309 7664088 163.95 µM 1.60629041944695 0.0533835750336509 no 224 0.0541050571952593 418 704922
SGTC_831 k061-1017 217 µM 1.60036503848549 0.054037770795898 no 225 0.0547588131490904 536 1240153
SGTC_2703 st077852 53.4 µM 1.59887987041185 0.0542027324157674 no 226 0.0549236487859873 361 6281836
SGTC_1197 1601-0112 267 µM 1.59569628672576 0.054557684162214 no 227 0.055278309041855 396 7350313
SGTC_1287 0971-0001 34.6 µM 1.59095344800488 0.0550898903191474 no 228 0.0558100263455981 428 4665869
SGTC_988 1497-1057 103 µM 1.59064730455108 0.0551243838952567 no 229 0.0558444861084616 389 3533044
SGTC_3266 9136860 49.47 µM 1.58993353044388 0.0552048720045711 no 230 0.0559248943139317 379 4871271 YPR165W RHO1
SGTC_3328 9140624 29.0385 µM 1.58712682911391 0.0555222677292171 no 231 0.0562419613017645 379 4904392
SGTC_128 0906-2981 13.371 µM 1.58342133810945 0.0559435074569035 no 232 0.0566627313270239 331 6740226
SGTC_3131 9127911 49.47 µM 1.58333512072927 0.0559533385653865 no 233 0.0566725510208378 373 45595681
SGTC_1605 st000082 49.1 µM 1.58259465488581 0.0560378277796724 no 234 0.0567569412890579 347 1114022
SGTC_2438 5259590 200 µM 1.58201916537259 0.0561035621998741 no 235 0.0568225976780226 381 1201127
SGTC_1154 4088-0362 150 µM 1.58153470644664 0.056158945916766 no 236 0.0568779149391295 449 6618304
SGTC_1561 5-methoxyflavone 52.9 µM 1.57093724680159 0.0573812745964876 no 237 0.0580986129103316 283 94525
SGTC_2692 st077426 47.7 µM 1.56265353174055 0.0583512302188009 no 238 0.0590670548730374 395 25238571
SGTC_2328 6201408 200 µM 1.56004407193264 0.0586594296081857 no 239 0.0593747333534525 375 2890418
SGTC_297 0986-0032 24 µM 1.55760472026263 0.0589486920137584 no 240 0.0596634895282999 333 2847425
SGTC_1990 st072050 59.8 µM 1.55738669126186 0.0589746006469363 no 241 0.0596893520043723 369 17233948
SGTC_1546 5-methoxyflavanone 78.7 µM 1.55708039048097 0.0590110138060698 no 242 0.059725700066287 383 147795
SGTC_1196 1588-0294 184 µM 1.55515196494159 0.0592406710368192 no 243 0.0599549406587281 357 6144269
SGTC_664 1222-0054 14.9 µM 1.55405810079197 0.0593712510946672 no 244 0.0600852791611325 407 6813991
SGTC_2629 bisabolol 100 µM 1.54796780448268 0.0601024105112867 no 245 0.0608150240926033 423 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1807 st050092 58.9 µM 1.54468574988247 0.0604993446341598 no 246 0.0612111466881396 383 5008496
SGTC_2520 obtusaquinone 4.71 µM 1.53905358012289 0.0611852798984513 no 247 0.0618956081176368 391 5967872
SGTC_75 0159-0059 199.013 µM 1.53845148302176 0.0612589667323056 no 248 0.0619691312836649 385 5377270
SGTC_2898 9056270 58.44 µM 1.52836009849298 0.0625043341192533 no 249 0.0632115779877701 330 19154699
SGTC_1904 st060225 78 µM 1.52763295547027 0.0625948269615352 no 250 0.0633018473388963 380 66595
SGTC_2402 5553605 200 µM 1.52284103290742 0.0631937374094082 no 251 0.0638992406873589 422 6758546
SGTC_2521 angolensin 13.4 µM 1.52226732484726 0.0632657394435404 no 252 0.0639710559145914 368 821428 A flavenoid.
SGTC_3025 9087895 49.47 µM 1.51865404207315 0.0637206858505576 no 253 0.064424800217194 424 17173641
SGTC_3076 9116187 49.47 µM 1.51341824320058 0.0643844332607566 no 254 0.0650867269476942 382 27241210
SGTC_1485 3909-9022 254 µM 1.50690847160568 0.0652171610983666 no 255 0.0659170598390007 418 714516
SGTC_2003 4023581 200 µM 1.5062448795194 0.0653025147831906 no 256 0.0660021611536054 425 16641307
SGTC_2118 5526350 200 µM 1.50479987854764 0.0654886759791466 no 257 0.0661877675036104 429 743594
SGTC_1034 k072-0165 12.7 µM 1.49952613801771 0.0661715919109149 no 258 0.0668685965482656 454 5835461
SGTC_2383 9036125 200 µM 1.49572803444897 0.0666668297139209 no 259 0.067362270819347 356 79580
SGTC_1280 0880-0253 10.1 µM 1.49509094741692 0.0667501802137495 no 260 0.0674453540587137 452 6836607
SGTC_1938 st074717 56.4 µM 1.49174919343808 0.0671887054402113 no 261 0.0678824537857491 356 17250979
SGTC_2514 salinomycin 42.74 µM 1.48717743531269 0.0677922434591594 no 262 0.0684839770222397 493 23682228 A polyether potassium ionophore.
SGTC_991 3996-0057 64.7 µM 1.48625652799392 0.067914321662048 no 263 0.0686056403009014 422 715343
SGTC_603 3794-0023 45.9 µM 1.48003631371326 0.0687433421465208 no 264 0.0694317779321737 394 3802260
SGTC_1642 st009582 77.7 µM 1.47892708489726 0.0688919948514509 no 265 0.0695799017855504 390 6739311
SGTC_2322 7413319 38.22 µM 1.47766561459773 0.0690613511359757 no 266 0.0697486511765044 608 1840400
SGTC_2938 9059746 27.26 µM 1.4759999756646 0.0692854595983204 no 267 0.0699719493821873 402 6471769
SGTC_2522 biochanin a 4.94 µM 1.47423029451418 0.0695241801259391 no 268 0.0702097978920188 392 5280373 A possible chelator.
SGTC_1525 8-methoxypsoralen 92.5 µM 1.4739231491068 0.0695656768252179 no 269 0.0702511420717612 493 4114 Related to psoralen; DNA damaging agent.
SGTC_2116 5511452 16.8835 µM 1.4682507573485 0.070335474845797 no 270 0.0710180607347664 457 870744
SGTC_1000 4048-0884 8.67 µM 1.46814764559349 0.0703495284726105 no 271 0.0710320609180304 445 13040088
SGTC_1688 st021091 57.6 µM 1.4669474439204 0.0705132689514244 no 272 0.071195176415048 409 3656366
SGTC_2170 morpholine 200 µM 1.46559918213622 0.0706975581245032 no 273 0.0713787571079506 396 121171 Reacts with secondary amines.
SGTC_1039 k821-0043 94 µM 1.46368341316702 0.0709600541765994 no 274 0.0716402347936785 443 15992768
SGTC_133 0724-0033 378.92 µM 1.45359832554958 0.0723542586685582 no 275 0.0730288507162497 409 280309
SGTC_495 decylubiquinone 155 µM 1.44901043127466 0.072995412815266 no 276 0.0736673347516035 444 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2061 5245884 80.95 µM 1.44782312789005 0.0731620436034544 no 277 0.0738332614141646 464 573863
SGTC_3049 9092223 49.47 µM 1.44631794337486 0.0733737052429351 no 278 0.0740440226214655 417 8623917
SGTC_1652 st011932 78 µM 1.44621679810252 0.0733879452420344 no 279 0.0740582018006903 435 1551076
SGTC_1808 st050063 61.5 µM 1.4400551268331 0.0742594247106934 no 280 0.0749259016039517 439 4011993
SGTC_1452 4194-0072 190 µM 1.43783005668659 0.0745760637062236 no 281 0.0752411394803721 497 1343545
SGTC_1454 4239-0054 42.6 µM 1.43771737937085 0.0745921256429629 no 282 0.075257129950951 511 1340767
SGTC_574 1315-0397 40 µM 1.43431756633215 0.075078005215629 no 283 0.0757408298192962 535 6794277
SGTC_2250 alverine citrate 130 µM 1.43269356570849 0.0753109471292424 no 284 0.0759727145467041 619 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_712 r015-0009 80.6 µM 1.43106825366645 0.0755446283486012 no 285 0.0762053273341829 414 6813872 YLR060W FRS1
SGTC_2176 5809774 33.9695 µM 1.4308153868918 0.0755810341895468 no 286 0.0762415660117926 461 2870539
SGTC_374 0880-0231 82.3 µM 1.42765322769582 0.0760374273868707 no 287 0.0766958474490191 469 6833587
SGTC_581 0958-0271 211 µM 1.42655601990212 0.0761962763145779 no 288 0.0768539543792058 566 4591145
SGTC_915 methyl methanesulfonate (MMS) 110 mM 1.42642066430583 0.0762158899919899 no 289 0.076873476189839 458 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_428 3448-4153 16.5 µM 1.42556614803479 0.0763398022257166 no 290 0.0769968067763251 415 3834874
SGTC_2622 2-methoxyxanthone 59.94 µM 1.42075964635521 0.0770396442437053 no 291 0.0776933228946271 474 71034 A hepatoprotective.
SGTC_271 rotenone 740 µM 1.42004376744712 0.077144294367363 no 292 0.0777974697541574 502 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_2671 danthron 100 µM 1.41429182305049 0.0779890614705723 no 293 0.0786381184153005 459 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_554 4483-2211 187 µM 1.41299021012773 0.0781811948707494 no 294 0.0788293013149423 469 747107
SGTC_2154 5570129 200 µM 1.40211735044067 0.0798002063973343 no 295 0.0804401033687201 516 673366
SGTC_2551 apiole 73.87 µM 1.40128779378044 0.0799247641754923 no 296 0.0805640149005402 320 10659 A possible DNA adduct former.
SGTC_2367 9070478 135.38 µM 1.40087554107009 0.079986718501938 no 297 0.0806256470160373 502 572802
SGTC_783 0848-0141 92.7 µM 1.39823957317676 0.080383716740938 no 298 0.0810205684256086 455 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_293 4049-0273 38.5 µM 1.39744471288054 0.0805037208613632 no 299 0.0811399406484869 432 1380311
SGTC_591 4299-0174 154 µM 1.39677253409668 0.0806053087027259 no 300 0.0812409920773947 470 5509088
SGTC_1972 st070201 17.4 µM 1.39512896439024 0.0808541127506544 no 301 0.0814884766215086 490 2829099
SGTC_3286 9117135 37.221 µM 1.39478390008296 0.0809064222485464 no 302 0.0815405076657534 481 3438150
SGTC_1270 0831-1170 17.3 µM 1.39419281285197 0.0809960865740166 no 303 0.0816296938549411 530 6764716
SGTC_2715 st079500 56.4 µM 1.39383364363543 0.0810506069744616 no 304 0.0816839230091468 441 28246688
SGTC_2437 5741531 144.16 µM 1.38484467455971 0.0824241324121306 no 305 0.0830499835999953 514 2262990
SGTC_1127 asiatic acid 681.4 nM 1.38349644754852 0.0826316456611438 no 306 0.0832563479195618 492 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_321 4534-3890 65.3 µM 1.38235532287967 0.0828075896602527 no 307 0.08343131347369 483 699746
SGTC_1946 st076057 65.1 µM 1.38208018474408 0.0828500539043393 no 308 0.0834735409789844 350 953009
SGTC_638 3970-0837 4.09 µM 1.38179603809442 0.0828939256982184 no 309 0.0835171679462716 497 4118451 YLR208W SEC13
SGTC_1433 4060-0023 7.6 µM 1.38159958157535 0.0829242684918979 no 310 0.083547341268957 489 3840627
SGTC_1604 st002052 72.4 µM 1.3798597879549 0.0831933450873295 no 311 0.0838149099075128 494 6254834 YHR062C RPP1
SGTC_795 0685-0265 78 µM 1.37875037193015 0.0833652699100401 no 312 0.0839858664374578 511 302754
SGTC_3114 9122766 49.47 µM 1.37698586022729 0.08363926407617 no 313 0.084258309755749 469 17176985
SGTC_3014 9081533 49.47 µM 1.37607747917501 0.0837805814407814 no 314 0.0843988235593732 506 21367265
SGTC_3075 9116269 49.47 µM 1.37487916237756 0.0839672785332527 no 315 0.084584455221103 497 17015205 YNL244C SUI1
SGTC_1772 st048439 82.2 µM 1.37300488859596 0.0842599155334045 no 316 0.0848754134748395 521 2927068 YDL195W SEC31
SGTC_2052 5265182 7.135 µM 1.37293258642478 0.084271219641295 no 317 0.0848866525217759 506 1239884
SGTC_891 0929-0073 133 µM 1.37234498581529 0.0843631304764471 no 318 0.0849780337742713 479 5603632
SGTC_2906 7926292 26.41 µM 1.37035894079917 0.0846743388494805 no 319 0.0852874412249682 503 2966319
SGTC_1851 st056236 18.9 µM 1.36992866682219 0.0847418750536153 no 320 0.0853545850266773 503 5393171
SGTC_1342 1486-1464 234 µM 1.36787004789639 0.0850655568450283 no 321 0.0856763783570685 518 3253938
SGTC_1864 st057645 30.4 µM 1.36423334472386 0.0856396276834819 no 322 0.086247068356448 455 688666
SGTC_1519 esterone 74 µM 1.3611389429352 0.0861303736501036 no 323 0.0867348924752887 519 698 A steroid.
SGTC_117 lucigenin 22.078 µM 1.36034512742258 0.0862566044855225 no 324 0.0868603670477757 565 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.35847622862777 0.0865543390256679 no 325 0.0871563102498582 464 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.35615589103711 0.086925060527308 no 326 0.0875247864706828 522 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1255 0566-0045 221 µM 1.35215643954413 0.0875668372506051 no 327 0.0881626376956312 537 2788469
SGTC_3253 9135987 49.47 µM 1.35151366397508 0.0876703099430849 no 328 0.0882654729364219 445 4182430
SGTC_2266 7929956 200 µM 1.34929766032443 0.0880277370476685 no 329 0.0886206884210925 542 2967153
SGTC_36 0335-0881 14.2 µM 1.34815658121857 0.0882122090071414 no 330 0.0888040130969469 585 23828853
SGTC_449 xestospongin c 11.1929 µM 1.34669527273867 0.0884488712831423 no 331 0.089039197701596 545 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1755 st041960 45.185 µM 1.34627969462975 0.0885162614368587 no 332 0.0891061658952574 494 2257073
SGTC_1989 st071868 50.2 µM 1.34464078677522 0.0887823996695982 no 333 0.0893706325791227 530 16414057
SGTC_980 1473-0395 201 µM 1.34326645825829 0.0890060324659679 no 334 0.0895928544719649 454 768876
SGTC_1027 k015-0025 8.67 µM 1.34030698002859 0.0894890263784197 no 335 0.0900727815718285 532 3598955
SGTC_2771 fluoxetine 41.05 µM 1.33978989616107 0.089573615370412 no 336 0.0901568307135585 489 3386 A selective serotonin reuptake inhibitor.
SGTC_2470 5664817 21.68 µM 1.33977923427005 0.0895753601589512 no 337 0.0901585643582024 488 2859561
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.33915118751056 0.0896781828452907 no 338 0.0902607297078496 560 66535 A nucleotide analog.
SGTC_335 4077-0256 27.6 µM 1.33868507208647 0.0897545511375003 no 339 0.0903366090055366 596 3121989
SGTC_1487 3970-0795 2.82 µM 1.33771430631954 0.0899137564536597 no 340 0.0904947927827859 537 3765103
SGTC_3111 9122088 49.47 µM 1.33687353862278 0.0900518116378036 no 341 0.0906319598116012 394 16876704
SGTC_1405 3909-7894 12 µM 1.33684517382265 0.0900564719208654 no 342 0.0906365900758617 518 7104060
SGTC_2996 9066192 71.4286 µM 1.33138548803226 0.0909568282528784 no 343 0.0915311009833426 531 6472854
SGTC_886 0866-0150 153 µM 1.33024335810401 0.0911460184859201 no 344 0.0917190513931988 548 271463
SGTC_3168 9103419 49.47 µM 1.32362066064554 0.0922488027908849 no 345 0.0928145299832631 415 16649256
SGTC_1568 digitonin 820 nM 1.32288011929254 0.0923727259655491 no 346 0.0929376238444607 577 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2976 9009005 19.48 µM 1.32166628836843 0.0925761164304348 no 347 0.0931396495592304 528 2993148
SGTC_743 1275-0778 158 µM 1.321163695899 0.0926604281346274 no 348 0.0932233942123809 555 2849257 YMR203W TOM40
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.31821281371626 0.0931565951883571 no 349 0.09371620861631 497 2374 Ca(2+)-ATPase inhibitor.
SGTC_790 1575-0012 79.1 µM 1.31815560211995 0.0931662342215433 no 350 0.0937257822542604 546 378741 YLR208W SEC13
SGTC_2693 st077581 40.7 µM 1.31741282096159 0.0932914452047427 no 351 0.0938501428447118 637 25238761
SGTC_2020 4017018 200 µM 1.31411241538434 0.0938492999131577 no 352 0.094404188341244 535 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_3313 9133968 57.047 µM 1.3096386338643 0.0946094113811543 no 353 0.0951590561752585 560 1494643
SGTC_2928 9011484 9.79 µM 1.30313355052534 0.0957227307345298 no 354 0.0962645855862349 496 2994751
SGTC_2155 5570423 76 µM 1.30163269476911 0.0959809592378712 no 355 0.0965209888262738 523 797402
SGTC_1309 pyrazolanthrone 13.4 µM 1.29794999498755 0.0966167530799232 no 356 0.0971522593448724 582 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_555 4296-0685 37 µM 1.29793771240147 0.0966188787512219 no 357 0.0971543698236631 554 2908540 YHR072W ERG7
SGTC_1998 st075797 76.8 µM 1.29461171163458 0.0971957540632958 no 358 0.0977271050955071 598 24208315
SGTC_2840 9008771 71.43 µM 1.29198866913527 0.0976524850063637 no 359 0.0981805343011296 484 2992978
SGTC_3230 9131665 49.47 µM 1.2901076277418 0.0979809843656007 no 360 0.0985066459289773 407 15943720
SGTC_1087 pterostilbene 9.05 µM 1.28890468466015 0.0981914867954109 no 361 0.0987156126154714 587 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1313 1220-0047 237 µM 1.28871903705977 0.0982240026660891 no 362 0.0987478908683013 610 3528706
SGTC_2474 5321570 43.32 µM 1.28505896406729 0.0988666698343813 no 363 0.099385840002122 527 2841384
SGTC_2934 9036370 36.88 µM 1.28283695765872 0.0992583267505315 no 364 0.099774601590137 584 6462800
SGTC_2870 9038528 12.99 µM 1.28209698619097 0.0993890076149565 no 365 0.0999043130368624 494 6463316
SGTC_276 colchicine 750 µM 1.27978624625428 0.0997978997720698 no 366 0.100310161143662 595 2833 A microtubule depolymerizer.
SGTC_3101 9120531 49.47 µM 1.27954397200058 0.0998408419771077 no 367 0.100352782712538 578 24824904
SGTC_2618 avocadyne 43.43 µM 1.27266850170408 0.101065125417008 no 368 0.101567849675392 535 3015189
SGTC_854 0422-0053 192 µM 1.27115658586021 0.101335806848357 no 369 0.101836473952129 557 3596728
SGTC_1488 4013-0813 75.9 µM 1.2623100149504 0.102930218254353 no 370 0.103418627188847 508 2910057
SGTC_1936 st074407 74.3 µM 1.26185292053229 0.103013092456239 no 371 0.103500857717677 609 809813
SGTC_1937 st074714 47.2 µM 1.26152354649024 0.103072840159646 no 372 0.103560140972245 559 17250970
SGTC_2602 kawain 100 µM 1.26141437106274 0.10309264988731 no 373 0.103579796635737 634 5369129
SGTC_2555 cholic acid 100 µM 1.25929941054199 0.103476952284676 no 374 0.10396110303725 565 6708657 Influences liver metabolism.
SGTC_301 4119-0100 24.5 µM 1.25810568603414 0.103694318486274 no 375 0.104176768621274 634 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1552 6-methylflavone 10.6 µM 1.2552760698648 0.104210888353678 no 376 0.104689279547843 509 689013
SGTC_2537 larixol 68.93 µM 1.25383030691223 0.104475543241978 no 377 0.104951845454001 632 6708759
SGTC_796 1234-0020 70.7 µM 1.25004798941126 0.105170220016244 no 378 0.105641008707678 583 46495034
SGTC_518 1021-0119 62.6 µM 1.24804027665121 0.105540320405689 no 379 0.106008153889466 572 1097762
SGTC_2502 avocadyne acetate 18.59 µM 1.24624218535858 0.105872578010185 no 380 0.106337747991929 646 3952079
SGTC_2944 9067346 25.62 µM 1.24418226730167 0.106254145249559 no 381 0.106716244293906 575 6473075
SGTC_1097 itavastatin 7.23 µM 1.24316091745937 0.106443702054083 no 382 0.106904270694546 597 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3293 9120939 62.045 µM 1.24189458155948 0.10667906578382 no 383 0.107137729768654 572 934087
SGTC_1763 st044482 94.5 µM 1.23777642349391 0.1074470712905 no 384 0.107899486367555 605 88505
SGTC_2050 5263056 171 µM 1.23752632104352 0.107493841545875 no 385 0.10794587440647 671 763468 YGL055W OLE1
SGTC_2301 7769476 200 µM 1.23692703713075 0.107605969961451 no 386 0.108057085708182 524 977820
SGTC_1349 flufenamic acid 69 µM 1.23683775154708 0.107622682861934 no 387 0.108073661817749 552 3371 A non-steroidal anti-inflammatory.
SGTC_1696 st025591 34.7925 µM 1.23531191597139 0.107908585169394 no 388 0.108357220325424 609 2787147
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.23473606323246 0.108016627190678 no 389 0.108464374782004 564 688803
SGTC_237 nikkomycin 200 µM 1.23365655914531 0.108219374564951 no 390 0.108665453861503 627 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2669 eugenol 100 µM 1.2325727807295 0.108423200122721 no 391 0.108867598676264 528 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1465 k213-0056 144 µM 1.23090409872685 0.10873756795989 no 392 0.109179367233465 576 24048857 YMR208W ERG12
SGTC_746 1095-0025 46.6 µM 1.22863128280757 0.109166803958138 no 393 0.109605040522642 630 6749286
SGTC_2653 dihydrofissinolide 100 µM 1.22711664506158 0.109453528330146 no 394 0.109889376300865 570 6857746
SGTC_904 1141-0088 396 µM 1.22477081665396 0.109898665842251 no 395 0.110330791731013 577 1378119
SGTC_2994 9053520 71.4286 µM 1.22441602491823 0.109966103024387 no 396 0.110397663567799 601 4647384
SGTC_737 1950-0117 57.9 µM 1.22420519029488 0.110006191563226 no 397 0.110437415851313 588 5393513
SGTC_2201 6605497 169.863 µM 1.22085451355965 0.110644704290276 no 398 0.111070554665403 571 670741
SGTC_77 0828-0286 12.516 µM 1.21880811684275 0.11103597451939 no 399 0.111458515021605 609 745345
SGTC_2955 9076254 12.21 µM 1.21757038815354 0.111273108154335 no 400 0.1116936364852 560 16459619
SGTC_2188 6126565 140.678 µM 1.21599861552557 0.111574762748876 no 401 0.111992724704629 555 874518
SGTC_2467 5474540 200 µM 1.21373863351129 0.112009523306153 no 402 0.11242377329163 605 5413519
SGTC_1091 telmisartan 47.6 µM 1.21203262460258 0.112338515447735 no 403 0.112749946221145 610 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_3055 9094636 49.47 µM 1.21078446487406 0.112579651497921 no 404 0.112989010315775 571 25236176
SGTC_1631 benzylvanillin 81.9 µM 1.20784371153788 0.113149246265919 no 405 0.113553692132213 636 75506
SGTC_2876 9059903 25.97 µM 1.20780943085603 0.11315589819683 no 406 0.113560286533097 667 6916095
SGTC_679 0422-0091 41.4 µM 1.20742373690125 0.113230758690916 no 407 0.113634499341444 639 627384 YHR062C RPP1
SGTC_417 st075190 100 µM 1.20620460371051 0.113467616228261 no 408 0.113869304641431 647 222757
SGTC_2159 5658611 73.75 µM 1.20531648525045 0.113640385349221 no 409 0.114040573975674 600 793844
SGTC_2153 5569715 200 µM 1.19847498179164 0.114977578249272 no 410 0.115366078510629 607 2054701
SGTC_13 0199-0087 65 µM 1.19818248278144 0.115034996480601 no 411 0.115422991686475 639 4589825
SGTC_1606 st000094 49.2 µM 1.19792591067992 0.11508537896218 no 412 0.115472930786396 663 1242210
SGTC_2891 9063876 19.48 µM 1.19631426411117 0.115402213188479 no 413 0.115786972213519 548 6472478
SGTC_156 3474-0145 5.642 µM 1.1944954004571 0.115760528289393 no 414 0.116142119426716 632 2265471
SGTC_1104 tacrolimus 29.8 µM 1.19045226138751 0.11655985294359 no 415 0.116934341305201 668 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2432 5630864 12.22 µM 1.19040020640811 0.116570169621705 no 416 0.116944565987329 613 5714970
SGTC_253 dyclonine 31.25 µM 1.18929985421381 0.116788397883439 no 417 0.11716084634638 677 3180 An oral anasthetic.
SGTC_3278 9139605 49.47 µM 1.1853225761535 0.117579609715455 no 418 0.117944965300358 622 7958859
SGTC_1804 st050076 49.1 µM 1.18359773400479 0.117923914730795 no 419 0.118286168913318 645 3895976
SGTC_2167 5876490 200 µM 1.18105120652952 0.11843354370677 no 420 0.11879119088343 641 686534
SGTC_2567 aureobasidin a 60 nM 1.18019203003293 0.118605838858696 no 421 0.118961924090322 637 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2299 7976368 114.88 µM 1.17899702012675 0.118845774813981 no 422 0.119199681204119 619 2979718
SGTC_151 3013-0144 2.285 µM 1.17849113732703 0.118947449967399 no 423 0.119300431757229 657 906558 YHR107C CDC12
SGTC_758 0868-0029 16 µM 1.17758421222655 0.119129882588226 no 424 0.119481203467466 645 762687
SGTC_3321 9137793 26.8275 µM 1.17560658514377 0.119528377133732 no 425 0.119876061435354 666 4904192
SGTC_317 4495-0002 170 µM 1.17092979537162 0.120474495395636 no 426 0.120813498752836 588 15991618
SGTC_1354 1498-1681 81 µM 1.16861963687085 0.120943783279246 no 427 0.12127845649374 687 5754243
SGTC_373 0844-0104 25.9 µM 1.16597756433427 0.121482071543227 no 428 0.121811758297923 692 5375804
SGTC_3107 9121808 49.47 µM 1.16507252265534 0.121666848818577 no 429 0.121994819065729 563 662681
SGTC_1312 1218-2183 165 µM 1.16503389743629 0.121674739104613 no 430 0.122002635999541 677 6744073
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 1.16498771544155 0.121684173546352 no 431 0.122011982727912 632 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1172 0370-0043 85 µM 1.16321631244097 0.122046438552041 no 432 0.122370874879903 620 376585
SGTC_18 0111-0177 500 nM 1.16265782096721 0.122160811065532 no 433 0.122484180584118 757 721752
SGTC_2138 5575593 77.673 µM 1.16200820392927 0.122293939675133 no 434 0.122616066262427 609 762213
SGTC_711 k292-0785 179 µM 1.16083423364427 0.122534784334043 no 435 0.122854659114701 645 4146315
SGTC_230 MPP+ 141.667 µM 1.1604889091166 0.12260569233234 no 436 0.122924903365217 623 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_739 1486-1183 203 µM 1.15815379357087 0.123085934099472 no 437 0.123400640374599 686 4346692
SGTC_2002 4023503 131 µM 1.1554232896383 0.123649162205329 no 438 0.123958564606858 776 4736863 YCR052W RSC6
SGTC_2409 alverine citrate 63.97 µM 1.15370991074247 0.124003505463035 no 439 0.12430955966806 648 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_466 geldanamycin 89.2 µM 1.14619314338803 0.125566439840482 no 440 0.125857622155523 533 5288382 HSP90 inhibitor.
SGTC_3254 9136651 49.47 µM 1.14349887147203 0.126129982517346 no 441 0.12641576150207 688 16454030
SGTC_710 3448-4187 58 µM 1.1399293699208 0.126879302807179 no 442 0.127157863950835 757 3946412
SGTC_2063 5246145 200 µM 1.13979800263706 0.126906938814002 no 443 0.127185233031907 692 711240
SGTC_2207 7258803 200 µM 1.13965755652453 0.126936489387113 no 444 0.127214498130618 620 3666799
SGTC_859 0439-0102 54.6 µM 1.13721809627889 0.127450528374983 no 445 0.127723561894179 735 610143
SGTC_870 0573-2213 57.6 µM 1.1370575948242 0.127484399656319 no 446 0.127757104727651 653 3916321
SGTC_2425 5628681 7.85 µM 1.13661793457308 0.127577215021867 no 447 0.127849019677346 765 5714958
SGTC_2478 5763493 32.33 µM 1.13327384191662 0.128284714194656 no 448 0.128549636553424 701 1365576 YLR208W SEC13
SGTC_3047 9092122 49.47 µM 1.13250202765118 0.12844839072868 no 449 0.128711716201581 644 17173831
SGTC_1706 st031321 9.9705 µM 1.1308527066171 0.128798643439918 no 450 0.129058545822956 693 6103185
SGTC_818 4072-2707 53.5 µM 1.13036012935488 0.128903376376963 no 451 0.129162253626062 652 882871
SGTC_3306 9127676 59.7925 µM 1.12977483447243 0.129027899926544 no 452 0.129285557398671 640 41905287
SGTC_3322 9139058 2.11 µM 1.12655397046797 0.129714642499304 no 453 0.129965554851353 703 4908926 YPR165W RHO1
SGTC_2016 5121758 140 µM 1.12317906650516 0.130436940482698 no 454 0.130680725653255 729 2795203
SGTC_1022 4477-0945 21.3 µM 1.12279099109836 0.130520174481681 no 455 0.130763136202138 690 4648966
SGTC_3314 9135860 59.4275 µM 1.12124833073988 0.130851405791943 no 456 0.131091086197376 714 25252478
SGTC_2280 7785178 200 µM 1.12122754039243 0.130855873741689 no 457 0.131095509837995 653 2954328
SGTC_3006 9075424 71.4286 µM 1.1208688133339 0.130932982587338 no 458 0.131171853787175 636 7465181
SGTC_1279 0874-0590 65.2 µM 1.12037088702619 0.131040064520213 no 459 0.131277872873196 711 3523074
SGTC_577 r071-0003 38.6 µM 1.11475852046228 0.132251221404363 no 460 0.132476957959576 831 4568517 YMR134W ERG29
SGTC_685 1278-0033 54.9 µM 1.11472832214719 0.132257759048811 no 461 0.132483430192382 709 3590572
SGTC_1470 k295-0292 231 µM 1.11403900479842 0.132407050200979 no 462 0.13263122690337 723 5045612
SGTC_1036 k216-0215 33.5 µM 1.11307667572123 0.132615663931153 no 463 0.132837750032685 711 622330
SGTC_1987 st072290 61.9 µM 1.11280956135876 0.132673609116728 no 464 0.132895114046261 712 54697379
SGTC_2136 5328288 199.296 µM 1.11277980899682 0.132680064383331 no 465 0.132901504555656 606 262395
SGTC_484 loperamide 105 µM 1.11253147729506 0.132733952488583 no 466 0.132954851971398 584 3955 An opioid-receptor agonist.
SGTC_1616 st002734 56.1 µM 1.11209425484532 0.132828866611627 no 467 0.133048813329767 730 4026101
SGTC_1973 st070275 50.2 µM 1.10817651493817 0.133681432082972 no 468 0.133892795645321 666 17118334
SGTC_1618 st003135 44.5 µM 1.10807667894858 0.133703207105555 no 469 0.133914350863389 675 1270615
SGTC_2751 anetholtrithion 17.25 µM 1.10736349006226 0.133858830197281 no 470 0.134068402196971 687 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3352 9151559 45.5865 µM 1.10716219123014 0.133902777611636 no 471 0.134111905483994 662 17159339
SGTC_1678 st019265 80.2 µM 1.10627817158353 0.134095893523497 no 472 0.134303068391082 726 5367020
SGTC_1047 2043-3044 82 µM 1.10357047133704 0.134688586406632 no 473 0.134889753123188 714 669592
SGTC_400 oxethazaine 37.5 µM 1.10028347643626 0.135410494609638 no 474 0.13560431461593 669 4621 A local anesthetic.
SGTC_582 0987-0078 156 µM 1.09749829151821 0.13602426438284 no 475 0.136211813594872 837 1625765
SGTC_720 r052-1644 49.9 µM 1.09744739242658 0.136035498681225 no 476 0.136222932904739 630 1422863 YOR257W CDC31
SGTC_1666 st014829 29 µM 1.09615485537429 0.136320996541964 no 477 0.136505506039546 735 3858230
SGTC_1715 st032160 10.2275 µM 1.09558881691554 0.136446153096379 no 478 0.136629378928784 683 5289825
SGTC_849 0386-0493 241 µM 1.09488430300673 0.136602037669581 no 479 0.136783663379888 682 726119
SGTC_1891 st059073 26.2 µM 1.09258887393139 0.137110781363774 no 480 0.137287174961125 777 688754
SGTC_3119 9125183 49.47 µM 1.09215015479513 0.137208163320103 no 481 0.137383553670295 563 22695334
SGTC_1685 st024049 53.0905 µM 1.08945216669997 0.137808071001238 no 482 0.13797726876308 690 1941139
SGTC_2092 5303694 80.6725 µM 1.0878266299952 0.1381703778293 no 483 0.138335825510022 735 1963699
SGTC_246 cycloheximide 667 µM 1.08525351694896 0.138745211355124 no 484 0.138904693610483 628 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2064 5220758 200 µM 1.08473630676829 0.138860952453122 no 485 0.139019231286872 756 788518
SGTC_3042 9091578 49.47 µM 1.08263583369572 0.13933167109552 no 486 0.139485047712663 686 25236497
SGTC_1745 st081495 74 µM 1.08175432634319 0.139529541033314 no 487 0.139680853193057 781 13842402 YBL026W LSM2
SGTC_2564 betulinic acid 100 µM 1.08097293783905 0.139705097236261 no 488 0.139854575882552 776 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_451 chloral hydrate 100 µM 1.07893149569671 0.140164460811299 no 489 0.1403091335879 783 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3073 9114972 49.47 µM 1.07856663131997 0.140246670240131 no 490 0.140390481682461 671 41905075
SGTC_1120 ficusin 1.78878 µM 1.07452685559754 0.141159081104163 no 491 0.141293307448449 743 6199 A DNA cross-linker.
SGTC_1874 staurosporine 7.6 µM 1.07214071637206 0.141699893544351 no 492 0.141828416599503 762 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_519 k048-0011 62.8 µM 1.07179652600477 0.141778019092141 no 493 0.141905716912347 722 6836379
SGTC_2918 7977171 22.06 µM 1.07168839556933 0.141802568941908 no 494 0.141930007374023 724 2236483
SGTC_1867 st057372 64 µM 1.06724433042113 0.142814036955433 no 495 0.142930759622608 714 688837
SGTC_3104 9120930 49.47 µM 1.06681424556004 0.14291218232562 no 496 0.143027862232926 672 17014836
SGTC_2642 cholecalciferol 100 µM 1.06623069874821 0.143045420579909 no 497 0.143159684038313 738 9821465 A vitamin D precursor, similar to steriods.
SGTC_1183 1254-0324 198 µM 1.06475425123933 0.143382904986577 no 498 0.143493576350189 749 5799357
SGTC_877 0771-0151 33.1 µM 1.0618578457032 0.144046522239072 no 499 0.144150112274358 764 6166523
SGTC_782 0083-0095 30.5 µM 1.06163006579201 0.144098798315403 no 500 0.144201829515704 791 3591729 An indicator and reagent.
SGTC_1799 st045822 46.1415 µM 1.06151317083398 0.144125630975868 no 501 0.14422837527616 722 3674992
SGTC_1041 0206-0046 107 µM 1.06065623232085 0.144322439853361 no 502 0.144423078655342 741 50494
SGTC_115 0527-0192 112.043 µM 1.06064009379592 0.144326148046458 no 503 0.144426747157584 831 4233931
SGTC_352 k048-0007 5.11 µM 1.05969132022362 0.144544263216655 no 504 0.144642526426567 798 6811911
SGTC_3010 9080089 71.4286 µM 1.05768819557498 0.145005494029219 no 505 0.145098809343938 749 17027233
SGTC_2412 st077135 33.4 µM 1.05605627374819 0.145381984850239 no 506 0.145471252957623 746 13258915
SGTC_1179 1021-1431 9.29 µM 1.05521427550212 0.145576494105386 no 507 0.145663668339966 778 2840958
SGTC_3013 9080133 71.4286 µM 1.0512662001779 0.146490868588542 no 508 0.146568173055233 813 17050193
SGTC_821 1114-0266 29.2 µM 1.0498016308161 0.14683104115221 no 509 0.146904662657685 732 3123235
SGTC_1486 3970-0793 4.53 µM 1.04899404333101 0.147018844345614 no 510 0.147090429982581 755 2844330
SGTC_1174 0739-0097 51.1 µM 1.04475474951895 0.14800732669206 no 511 0.148068166787597 766 728447
SGTC_313 3474-0040 5.03 µM 1.04399504118069 0.148184937924374 no 512 0.148243841946594 772 1043375 YIL048W NEO1
SGTC_162 k030-0015 37.8 µM 1.04209177889811 0.148630525092716 no 513 0.148684564869868 801 1809920 YMR134W ERG29
SGTC_2512 diallyl trisulfide 49.23 µM 1.03844604574407 0.149486554182951 no 514 0.149531220953143 724 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2129 girgensonine 121.053 µM 1.03809067416358 0.149570172156991 no 515 0.149613921384771 811 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_873 0591-4978 488 µM 1.03722511592111 0.149773966248626 no 516 0.149815477772365 836 3305145
SGTC_600 1495-0418 41.6 µM 1.03663552219876 0.149912891012794 no 517 0.149952875922743 744 5377768
SGTC_2247 cerulenin 830 nM 1.03157546638561 0.151108714507043 no 518 0.151135519163226 769 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1081 sertraline 6 µM 1.03034398925224 0.151400702393925 no 519 0.151424278079389 797 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.03021029158953 0.151432425178254 no 520 0.151455649803343 718 6708760
SGTC_139 0099-0334 718.624 µM 1.02733873589675 0.152114833375348 no 521 0.152130494241226 898 97690
SGTC_2245 6637752 200 µM 1.02715004814191 0.152159745293206 no 522 0.152174907564781 672 681890
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.02665377135758 0.152277912329605 no 523 0.152291762290787 784 229346 A bile salt which induces apoptosis.
SGTC_776 4476-4378 112 µM 1.02466212516713 0.152752750160824 no 524 0.152761319982009 734 2892008
SGTC_175 3793-3120 23.7 µM 1.02331168617043 0.153075272839407 no 525 0.153080250057704 727 5322297
SGTC_981 1488-1094 54.9 µM 1.023044556919 0.153139124226472 no 526 0.153143389608061 721 3449522
SGTC_3309 9129340 25.759 µM 1.02290088868097 0.153173472265582 no 527 0.153177354642953 838 17158987
SGTC_2283 7944793 200 µM 1.02061757157778 0.153720050468498 no 528 0.153717830543444 771 2970533
SGTC_125 0133-0007 11.75 µM 1.02022230707086 0.153814799441553 no 529 0.153811520239831 855 26541
SGTC_683 panaxydol 45 µM 1.01963955970449 0.153954560478447 no 530 0.153949717995506 802 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_14 0354-0009 295 µM 1.01934933247351 0.154024197378991 no 531 0.154018575634852 808 1713507
SGTC_2013 4024628 200 µM 1.01826889808819 0.15428361915401 no 532 0.154275092370797 707 5230760
SGTC_1274 0865-0114 173 µM 1.01790595607939 0.154370829511935 no 533 0.154361325421978 781 870624
SGTC_2316 5844804 197.44 µM 1.01710320294279 0.154563836650945 no 534 0.154552168388173 935 776813
SGTC_2874 9043904 71.43 µM 1.01655165444872 0.154696538678972 no 535 0.154683381423131 689 4463428
SGTC_1397 3532-0190 20.1 µM 1.01643254771432 0.154725205523802 no 536 0.154711726500857 716 5322280
SGTC_990 3985-0011 41.3 µM 1.01403048079147 0.155304088902931 no 537 0.155284104049641 732 5399565 YGL099W LSG1
SGTC_3176 9106582 49.47 µM 1.01355862973059 0.155417969866119 no 538 0.155396703310764 650 17018027
SGTC_1590 st077108 57.8 µM 1.01237383388282 0.155704162435579 no 539 0.155679672192563 785 5489485
SGTC_319 1348-1596 45.5 µM 1.01233090047176 0.155714539708041 no 540 0.155689932503496 832 5380505
SGTC_1420 4'-methoxyflavone 42 µM 1.01177683213988 0.155848502392345 no 541 0.155822384855712 805 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_266 formosanin C 406 nM 1.01176660821844 0.155850975046618 no 542 0.155824829624794 787 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_3264 9137442 49.47 µM 1.01106426631551 0.156020898274768 no 543 0.155992835878066 748 17015726
SGTC_1502 4534-4282 27.7 µM 1.01105880107259 0.156022221003549 no 544 0.155994143679359 752 3278949
SGTC_590 k048-0076 22.4 µM 1.00885006639487 0.156557396439786 no 545 0.156523272848585 779 6832814
SGTC_2948 9070189 9.45 µM 1.00787480957327 0.156794084923548 no 546 0.156757283096141 723 6473636 YDL196W YDL196W
SGTC_3080 9117754 49.47 µM 1.00771361536645 0.156833228373755 no 547 0.156795983373662 859 9550191
SGTC_3177 9107506 49.47 µM 1.00640622412683 0.157150945107709 no 548 0.157110100408023 766 8897194
SGTC_2260 7964312 200 µM 1.0036394892128 0.157824700101177 no 549 0.15777620664402 747 231951
SGTC_1070 indatraline 8.81 µM 1.0028822928313 0.158009422637646 no 550 0.157958828544843 786 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1283 0922-0125 16.4 µM 0.998523634823787 0.159075502078401 no 551 0.159012754788949 854 3360884
SGTC_3149 9097855 49.47 µM 0.996801103642821 0.15949811022594 no 552 0.159430531234252 793 25236625 YMR079W SEC14
SGTC_3276 9139060 49.47 µM 0.990529442435765 0.161043011577821 no 553 0.160957702798207 757 4870619
SGTC_3121 9125696 49.47 µM 0.989300465972923 0.161346886458635 no 554 0.161258078074885 823 1235365
SGTC_34 0469-0683 81.75 µM 0.989038680095288 0.161411663525706 no 555 0.161322108614646 813 3690923
SGTC_79 0052-0007 94.094 µM 0.988743163326189 0.161484807439062 no 556 0.161394409358869 822 2801472
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.988441000860687 0.161559618584081 no 557 0.161468357877157 809 2333 A French combination drug.
SGTC_2820 7989630 71.43 µM 0.979868326349641 0.16369150302566 no 558 0.163575559731048 705 2984098
SGTC_1284 0929-0043 16 µM 0.974575209063919 0.165016892699461 no 559 0.164885507904077 828 1239883
SGTC_921 1561-0023 372 µM 0.96917987540845 0.166375007766931 no 560 0.166227725090189 852 24050882
SGTC_1822 st052468 42 µM 0.966071670234284 0.167160673402634 no 561 0.167004159637579 809 2873678
SGTC_2483 5729050 27.16 µM 0.965875914444849 0.167210234820046 no 562 0.167053137905751 929 2865180
SGTC_1012 4112-3522 18 µM 0.964078209838421 0.167665820225816 no 563 0.167503358199098 872 3112398
SGTC_2360 9040895 200 µM 0.96384449758226 0.167725107696862 no 564 0.16756194687331 772 4914414
SGTC_2263 7948595 193.29 µM 0.963815322849061 0.167732509609227 no 565 0.167569261532568 779 2971371
SGTC_1810 st050138 53 µM 0.962710485202473 0.168012972429081 no 566 0.167846416674613 832 3444541
SGTC_2532 xanthone 78.9 µM 0.960297358350958 0.168626593050334 no 567 0.168452789601056 763 7020 An insecticide.
SGTC_1339 1486-1321 22.7 µM 0.959431381189894 0.168847148363596 no 568 0.168670736226515 843 3469382
SGTC_2426 5582046 32.21 µM 0.954335028420468 0.170148888871666 no 569 0.169957041245933 864 2251934
SGTC_1511 0906-3109 28.5 µM 0.95278278580563 0.170546646150672 no 570 0.170350068978434 924 2882180
SGTC_26 0302-0163 425.158 µM 0.952555658858967 0.170604896606378 no 571 0.170407626293815 872 3100915
SGTC_2419 paclitaxel 166.5 µM 0.952496058132022 0.170620184306434 no 572 0.170422732059167 871 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_938 3126-1755 342 µM 0.952360691702303 0.170654909311494 no 573 0.170457043778168 890 1777771
SGTC_531 3788-1495 174 µM 0.951682171945722 0.170829035418566 no 574 0.170629096793595 808 2896655
SGTC_385 1494-0393 12.4 µM 0.948963226699622 0.171527928760111 no 575 0.171319657667025 873 3090647
SGTC_1444 4112-3581 28 µM 0.948647921963621 0.17160909456907 no 576 0.171399854581761 886 2877249
SGTC_176 1486-1328 72.834 µM 0.945949510906046 0.172304723449652 no 577 0.172087169365755 878 22310231
SGTC_82 0054-0107 293.755 µM 0.945460212652738 0.172431053059066 no 578 0.172211987137981 870 3104697
SGTC_2755 lomerizine 42.69 µM 0.94531210226026 0.172469304628065 no 579 0.172249780816897 865 3949 A calcium channel blocker.
SGTC_2892 9047358 58.44 µM 0.945148614304136 0.172511533950285 no 580 0.172291504569621 786 6466771
SGTC_303 1348-1668 34.2 µM 0.944284727779825 0.172734787332192 no 581 0.172512084051453 846 5380509
SGTC_2134 5324836 1.464 µM 0.943544198491765 0.172926308151099 no 582 0.172701309545125 804 699272
SGTC_755 1995-0008 37.3 µM 0.940787073427103 0.17364056408272 no 583 0.173406993273991 894 689533
SGTC_1512 0259-0544 12.2 µM 0.937189895719385 0.174575260288694 no 584 0.174330443187659 904 18476
SGTC_1066 ketoconazole 628 nM 0.933882961202775 0.175437352587748 no 585 0.17518213447025 932 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2798 7813637 45.45 µM 0.932448033823251 0.175812265190636 no 586 0.175552515413799 852 956368
SGTC_485 niflumic acid 177 µM 0.931605670099558 0.176032591144457 no 587 0.175770175875479 834 4488 A COX2 inhibitor.
SGTC_1949 st076024 69.1 µM 0.93060386066305 0.176294848679529 no 588 0.17602925836403 889 2921930
SGTC_1102 cgs 12066b 26.1 µM 0.928924939734567 0.176734917121054 no 589 0.176463993556376 847 6438352 A 5-HT1B full agonist.
SGTC_3091 9116372 49.47 µM 0.9255453397438 0.177622860999706 no 590 0.177341155413809 831 17169793
SGTC_363 0455-0021 3.06 µM 0.92396217562589 0.178039782385621 no 591 0.177753004680658 878 4597466
SGTC_2388 9080168 200 µM 0.923780770845509 0.178087594143746 no 592 0.177800234388928 822 15943073
SGTC_1459 k035-0031 35.7 µM 0.923552943376984 0.178147652713887 no 593 0.177859561706101 788 3877128 YMR208W ERG12
SGTC_2396 5342950 42.78 µM 0.922895301502892 0.178321088098897 no 594 0.178030884693968 880 1886677
SGTC_1221 2958-7315 257 µM 0.922236408558522 0.178494960080796 no 595 0.178202637909886 840 4562705
SGTC_2205 7238770 200 µM 0.921505441502054 0.178687976245832 no 596 0.178393300792214 899 279867
SGTC_422 cantharidin 155 µM 0.920995297188689 0.178822760695762 no 597 0.178526441163748 856 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3094 9117742 49.47 µM 0.920787329164706 0.17887772596736 no 598 0.178580735797613 957 17149698
SGTC_657 3534-0529 86.7 µM 0.920606315474434 0.17892557595089 no 599 0.178628001872841 903 1049549
SGTC_1926 methyl fluorone black 53.6 µM 0.917210888155914 0.17982463097738 no 600 0.179516071174086 818 72721 Reacts with homocysteine.
SGTC_1048 3161-0300 24.5 µM 0.913265404797318 0.180872889775381 no 601 0.180551486264925 932 2165101
SGTC_1802 st050112 57.9 µM 0.911149458212807 0.181436641209892 no 602 0.181108315039119 923 4662563
SGTC_2837 9008476 45.46 µM 0.909145004817931 0.181971700939616 no 603 0.181636794598613 896 2992805
SGTC_1408 3909-7976 48.8 µM 0.908223056599054 0.182218132571907 no 604 0.181880192409599 940 24152374
SGTC_2212 7123476 200 µM 0.908213680063781 0.182220639938601 no 605 0.181882668897742 837 1085715
SGTC_2099 5377090 177.372 µM 0.905646469504574 0.182907945287153 no 606 0.182561502164736 877 2243829
SGTC_3139 9095020 49.47 µM 0.903917468481154 0.183371751851242 no 607 0.183019582840287 739 25236292
SGTC_2458 5808907 16.39 µM 0.902449245151827 0.183766179660275 no 608 0.183409135748192 979 2731747
SGTC_272 doxorubicin 8.13 µM 0.901947978918532 0.18390096221899 no 609 0.183542251313202 966 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2028 5153890 36.43 µM 0.900953704042284 0.184168489110576 no 610 0.183806467683825 883 2830968 YPR165W RHO1
SGTC_2380 9035439 200 µM 0.898432607640123 0.184847918886954 no 611 0.184477479465437 975 6462575
SGTC_610 4215-0184 155 µM 0.898285561962264 0.184887595387463 no 612 0.18451666392452 931 5605015
SGTC_2292 7671323 168.05 µM 0.897052039097739 0.185220638245945 no 613 0.184845574625674 893 937504
SGTC_847 0342-0274 5.54 µM 0.893497887580217 0.186182316642135 no 614 0.18579530143404 958 18097
SGTC_1404 3909-7820 48.3 µM 0.89287157097 0.186352104843297 no 615 0.185962976503048 927 23741373
SGTC_922 1866-0035 480 µM 0.892671899659698 0.186406253907812 no 616 0.186016451454489 999 3156169
SGTC_520 3584-0023 682 µM 0.892670437867413 0.186406650368675 no 617 0.186016842979388 841 1340790
SGTC_910 3454-3003 490 µM 0.891845141659583 0.186630566958415 no 618 0.186237971006283 940 820824
SGTC_2264 7948757 110.76 µM 0.89043820769058 0.187012675303261 no 619 0.186615317117553 884 2971411
SGTC_3344 9148862 3.898 µM 0.89006259120883 0.187114770553363 no 620 0.186716139180105 945 4905352
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.889869900664813 0.187167158599413 no 621 0.18676787379081 995 5024745
SGTC_642 0335-0876 158 µM 0.888439330920106 0.187556380612173 no 622 0.187152238378909 936 6812350
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.885696886536299 0.188303927855219 no 623 0.187890443256376 959 23665772 A membrane-active detergent.
SGTC_2075 5212009 200 µM 0.885127556509151 0.188459348374017 no 624 0.188043919277617 852 780898
SGTC_2439 5492030 7.2 µM 0.884575549185209 0.188610115510105 no 625 0.188192799431056 924 5722370
SGTC_358 0075-0058 9.45 µM 0.883754273029021 0.188834564334603 no 626 0.188414437799831 982 1069125
SGTC_3258 9138477 49.47 µM 0.883351577628181 0.188944678183192 no 627 0.188523172288445 939 4970355
SGTC_1107 amlodipine 47 µM 0.883210893387787 0.188983156489858 no 628 0.188561168503289 884 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_204 PMA1.184 62.41 µM 0.882974983441535 0.189047690650157 no 629 0.188624894019184 994 2252213 YGL008C PMA1
SGTC_1753 st043925 64 µM 0.882723789624252 0.189116420696988 no 630 0.188692762706415 957 670181
SGTC_721 1187-1332 279 µM 0.880761811030131 0.18965377407803 no 631 0.189223376786746 833 25730
SGTC_640 3381-0960 37.1 µM 0.879907763251106 0.189887976700767 no 632 0.189454639402795 993 1745025
SGTC_1698 5-fluorocytosine 1.055 µM 0.879357639438606 0.190038929401633 no 633 0.189603696283952 957 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_792 4534-1957 155 µM 0.877742938603367 0.19048242534853 no 634 0.190041618416062 941 1717904
SGTC_488 nitrendipine 139 µM 0.87737386481669 0.190583884821825 no 635 0.190141801933574 975 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_846 0335-0850 148 µM 0.875247303278911 0.191169128916052 no 636 0.19071968003891 939 6819598
SGTC_673 1082-0474 110 µM 0.873975092692273 0.191519776046877 no 637 0.191065909024026 1033 3098046
SGTC_813 k007-0158 173 µM 0.873962823379142 0.191523159636508 no 638 0.191069249962924 1015 6523916
SGTC_884 0851-0618 334 µM 0.87305918365621 0.191772463005761 no 639 0.191315409897805 960 9642473
SGTC_827 3253-0474 693 µM 0.872392733757199 0.191956455797193 no 640 0.191497081582793 981 5402065
SGTC_598 3937-0236 20.2 µM 0.872096423250567 0.192038295578713 no 641 0.191577888621702 995 1379313
SGTC_1106 tegaserod maleate 11.7 µM 0.871748026328085 0.19213454872818 no 642 0.191672926895656 946 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.869414526906946 0.19277999549748 no 643 0.192310220106711 949 115019
SGTC_2071 5230951 39.92 µM 0.867837575381587 0.193216930036379 no 644 0.19274162828053 1030 1799272
SGTC_1305 1181-0477 144 µM 0.866972252324348 0.193456946439909 no 645 0.192978606617215 962 6252086
SGTC_1742 st038235 28.8875 µM 0.865968272953088 0.193735650051272 no 646 0.193253780404491 904 564103 YBR002C RER2
SGTC_1700 st030840 7.9285 µM 0.86550476835847 0.193864400988266 no 647 0.193380899944134 978 5499307
SGTC_2977 9011197 71.43 µM 0.86540411308824 0.193892367602693 no 648 0.19340851213256 873 2704722
SGTC_923 1900-2434 73.3 µM 0.864417096641048 0.19416673593924 no 649 0.193679402172668 920 5910570
SGTC_3297 9117502 71.43 µM 0.863552176813947 0.19440735847045 no 650 0.193916972465582 970 7453720
SGTC_3287 9117173 37.0625 µM 0.863098651260094 0.194533602759643 no 651 0.19404161472324 950 2789709
SGTC_631 k072-0230 41.5 µM 0.861919018894648 0.194862201192962 no 652 0.194366041162471 981 5773147
SGTC_2227 7312221 64.1025 µM 0.860828088314729 0.195166391102656 no 653 0.194666366278698 977 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2646 retinol 96.75 µM 0.858471662302938 0.19582442996012 no 654 0.19531603579733 948 445354 A vitamin A analog and teratogen.
SGTC_158 k038-0087 26.446 µM 0.85785072835025 0.195998051474632 no 655 0.195487447085714 989 X158
SGTC_2334 9017922 200 µM 0.857184597490016 0.196184414444581 no 656 0.195671436703119 984 3163164
SGTC_645 0845-0943 5.41 µM 0.857074743168919 0.196215158630158 no 657 0.195701789266214 928 1885106
SGTC_3100 9120536 49.47 µM 0.856594973111891 0.196349462865884 no 658 0.195834382416367 861 16421196
SGTC_3318 9139014 38.6185 µM 0.855573351850427 0.196635635600422 no 659 0.196116907552752 937 16643984
SGTC_1563 conessine 56.1 µM 0.855058813136244 0.196779861887151 no 660 0.196259294660872 1080 441082 An anti-amoebic, histamine inhibitor.
SGTC_2200 6600604 21.907 µM 0.853246812306159 0.197288279363553 no 661 0.19676122425583 979 2904777
SGTC_1143 3454-2408 5.08 µM 0.850421198554252 0.198082683719075 no 662 0.197545477251152 942 X1143
SGTC_2187 6125751 200 µM 0.850242860594436 0.198132887082958 no 663 0.197595038516444 962 874498
SGTC_3205 9113483 49.47 µM 0.849811270065977 0.198254414576991 no 664 0.197715011399979 964 17018033
SGTC_1363 1636-0063 10.4 µM 0.848247865993718 0.198695015286708 no 665 0.198149972523205 1003 6072185
SGTC_2429 5902844 64.44 µM 0.848103795949826 0.198735646998147 no 666 0.198190083897553 1011 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1100 amiodarone 5.07 µM 0.847939505650112 0.198781987490751 no 667 0.198235830891779 1024 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1553 gossypol 38.6 µM 0.84790345895754 0.198792155861352 no 668 0.198245869024978 909 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_364 0083-0097 67.7 µM 0.847638227746611 0.198866984274548 no 669 0.198319738944657 954 5207356
SGTC_247 mechlorethamine 29.705 µM 0.846443910419913 0.199204141608435 no 670 0.198652575714797 940 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1554 st069299 38.7 µM 0.845999729593838 0.199329622215531 no 671 0.198776447560105 995 24207999
SGTC_3129 9127257 49.47 µM 0.844790245077466 0.199671541456139 no 672 0.199113981016477 846 837894
SGTC_3062 9077494 49.47 µM 0.844596845785228 0.199726247818376 no 673 0.199167985377173 942 16459633
SGTC_2005 4024620 188 µM 0.844458873438621 0.199765281213109 no 674 0.199206517840601 974 236743
SGTC_2795 7780010 54.55 µM 0.842815626977902 0.200230520463784 no 675 0.199665783417986 920 953673
SGTC_3123 9126162 49.47 µM 0.841497684797272 0.200604129016375 no 676 0.200034590750769 1003 25239884
SGTC_855 0428-0020 25 µM 0.841331397457258 0.200651297656371 no 677 0.200081152971917 903 6812414
SGTC_2471 5466956 24.79 µM 0.839807369114984 0.201083909707228 no 678 0.200508200505843 964 724419
SGTC_532 1548-0774 215 µM 0.839572610880007 0.201150598078232 no 679 0.200574030661349 1018 5932993
SGTC_164 4100-3994 89.624 µM 0.839491765154227 0.201173567199789 no 680 0.2005967041658 1045 4615967
SGTC_1933 st074711 15.9 µM 0.839300820542536 0.201227822817202 no 681 0.200650261448884 1045 17250958
SGTC_916 4466-0038 42 nM 0.837929272354902 0.201617796713921 no 682 0.20103521369488 1078 5722064 YGL116W CDC20
SGTC_1719 st032227 49.2 µM 0.8376874794663 0.201686592880195 no 683 0.201103123576518 1005 3125804
SGTC_2014 4013930 200 µM 0.837109701841338 0.201851042096324 no 684 0.201265453742946 1025 64556
SGTC_1316 1272-0050 65.9 µM 0.836606014948341 0.201994468811856 no 685 0.201407031736583 985 7340392
SGTC_2811 7967822 32.47 µM 0.835753966812679 0.202237231510781 no 686 0.20164666411481 963 2232244
SGTC_76 0433-0009 400.328 µM 0.834471215069577 0.202603037829842 no 687 0.202007750698999 885 2841569
SGTC_1055 3448-0672 86 µM 0.834468955541307 0.202603682535307 no 688 0.202008387083312 944 748378
SGTC_648 0375-0473 33.3 µM 0.832927085607294 0.203043906226815 no 689 0.202442926406822 1006 1713139
SGTC_927 2425-1185 123 µM 0.828929647564093 0.204187882946394 no 690 0.203572108943665 991 730375
SGTC_2836 9010338 19.48 µM 0.827534224096717 0.204588123812995 no 691 0.203967166150003 970 2994051
SGTC_1732 st034308 51.822 µM 0.826239644158979 0.204959857438583 no 692 0.204334081802857 945 830119
SGTC_3051 9093778 49.47 µM 0.825670988389329 0.205123271594572 no 693 0.204495376909403 975 17217378
SGTC_760 0568-0725 82.9 µM 0.822424059134392 0.20605782129153 no 694 0.205417795523799 1041 3916171
SGTC_2756 carbadox 75.1 µM 0.821505721315154 0.206322599872176 no 695 0.205679133273983 968 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2959 9079155 11 µM 0.82081447145853 0.206522036550377 no 696 0.205875977139523 972 16189457
SGTC_2174 5790901 200 µM 0.819862472820226 0.206796890294523 no 697 0.206147256042639 977 786020
SGTC_1431 4049-0260 9.09 µM 0.818963673723705 0.207056583303675 no 698 0.206403569746123 1015 3854841
SGTC_197 4544-0043 41.561 µM 0.81858783441653 0.207165232987719 no 699 0.206510805130748 1056 896523
SGTC_889 0919-1524 82.7 µM 0.818299200694519 0.207248695692473 no 700 0.206593181206862 966 3905452
SGTC_2880 9042983 58.44 µM 0.817656273316897 0.207434679106121 no 701 0.206776742649147 996 6464714
SGTC_1372 2752-0194 270 µM 0.817290613495904 0.207540499687674 no 702 0.20688118481694 943 823334
SGTC_3086 9117350 49.47 µM 0.817078532471704 0.207601889756136 no 703 0.206941775100583 987 2679265
SGTC_2670 beta-carotene 100 µM 0.816361679275106 0.20780947319913 no 704 0.20714665350765 968 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2986 9022445 71.43 µM 0.816149625985317 0.207870902218627 no 705 0.207207281847071 1009 6459286
SGTC_2779 methotrexate 400 µM 0.816135671885934 0.207874944911741 no 706 0.207211271843687 1111 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_490 phenamil 164 µM 0.815878480640052 0.207949465040852 no 707 0.207284820534518 951 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2272 7805186 180 µM 0.815728765699887 0.207992851604776 no 708 0.207327641454929 1012 2956062 YPR165W RHO1
SGTC_1901 st060216 58.6 µM 0.814763732855498 0.208272641016015 no 709 0.20760378211303 1053 688792
SGTC_2368 9071271 200 µM 0.812754043075788 0.208856017246158 no 710 0.208179544640372 996 27209959
SGTC_2046 4110841 106 µM 0.812256476369735 0.209000600319307 no 711 0.20832223952758 1034 44119630 YMR134W ERG29
SGTC_678 1218-2179 85.9 µM 0.806228745147766 0.210756817905494 no 712 0.21005548359198 1012 6820081 YOR116C RPO31
SGTC_1407 3909-7909 12.3 µM 0.806091675491648 0.210796854413357 no 713 0.210094995557855 1049 4411780
SGTC_1265 0819-1001 68.8 µM 0.805513943243807 0.21096565253408 no 714 0.210261581759067 1022 3106768
SGTC_2085 5307070 144.047 µM 0.805452415471892 0.210983633993747 no 715 0.210279327553231 973 2840351
SGTC_1442 4112-3290 3 µM 0.800804359558654 0.212344621851266 no 716 0.211622457394421 1075 704353
SGTC_2244 6635614 200 µM 0.800324817359853 0.212485326997187 no 717 0.211761313964368 881 836499
SGTC_3021 9087658 49.47 µM 0.800021706812184 0.212574292437258 no 718 0.211849110357869 1034 25237042
SGTC_47 0149-0135 24.25 µM 0.797166745112071 0.21341331406654 no 719 0.21267709837472 1041 5239155
SGTC_715 0868-0130 184 µM 0.796373507105053 0.213646774597725 no 720 0.212907486053955 1051 2876258
SGTC_309 k408-0051 1.48 µM 0.796141882269256 0.213714972933115 no 721 0.212974786528209 1059 3640463
SGTC_2873 9040596 71.43 µM 0.795969443907311 0.213765752963651 no 722 0.213024897952283 1074 6463863
SGTC_2675 theaflavin digallate 100 µM 0.795313878832599 0.213958869347279 no 723 0.213215471120656 1048 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_48 0382-0018 55 µM 0.794722053120978 0.214133296585172 no 724 0.213387600579914 1084 762596
SGTC_3007 9078383 71.4286 µM 0.794638316693398 0.214157982682938 no 725 0.213411961428255 1042 6496995
SGTC_376 3970-0862 59.1 µM 0.792865690504218 0.214680954008098 no 726 0.213928039339768 1070 3135186
SGTC_3334 9142812 21.919 µM 0.7925535615944 0.214773117029185 no 727 0.214018986935053 1010 45283678
SGTC_1218 1348-1416 30.7 µM 0.790865299776416 0.215272012262921 no 728 0.214511299731554 1074 6787668
SGTC_2290 7904846 200 µM 0.7900297688499 0.215519167088263 no 729 0.214755191649168 1060 2962154
SGTC_1325 1431-0015 227 µM 0.78984737193989 0.21557314301391 no 730 0.214808454820904 992 1103340
SGTC_2199 6590217 200 µM 0.787474976725338 0.216275909388082 no 731 0.215501935595458 1007 703109
SGTC_1030 k029-0042 36.7 µM 0.786823076187988 0.216469251666879 no 732 0.21569272145891 1060 6080581
SGTC_3288 9119690 36.221 µM 0.784700842202156 0.217099361448013 no 733 0.216314494441579 1008 17595618 YKL019W RAM2
SGTC_3108 9121785 49.47 µM 0.784171576689499 0.217256669939543 no 734 0.216469720360815 1050 17140271
SGTC_3331 9141060 1.957 µM 0.783403813070484 0.217484981903689 no 735 0.216695008855621 1028 4906567 YPR165W RHO1
SGTC_881 0833-0569 170 µM 0.78314324956162 0.217562497852895 no 736 0.216771498042341 1010 5418700
SGTC_2608 thymoquinone 42.66 µM 0.782342920520508 0.217800690219214 no 737 0.217006534591965 999 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1961 st076550 68.7 µM 0.781094066046152 0.218172672179201 no 738 0.217373585858732 1012 1579337
SGTC_2271 7849410 118.62 µM 0.780597499209181 0.218320680518914 no 739 0.217519631543969 1075 972430
SGTC_1191 1487-1166 10.6 µM 0.779588177325394 0.218621700521001 no 740 0.217816658535181 1139 3955771
SGTC_1521 st012942 49.4 µM 0.77947854012097 0.218654413084067 no 741 0.217848937058981 1093 24207259
SGTC_2662 daunorubicin 22.37 µM 0.778883006168444 0.218832152360543 no 742 0.218024317668664 1042 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3262 9137218 49.47 µM 0.778211353069615 0.219032709385502 no 743 0.218222212471203 948 17650664
SGTC_553 k007-0256 45.7 µM 0.777285838429562 0.219309243113075 no 744 0.218495074141353 1099 6287000
SGTC_3040 9091894 49.47 µM 0.775921097986386 0.219717378596493 no 745 0.218897787282772 1000 25236966
SGTC_569 4130-2812 160 µM 0.775832499016547 0.21974388982383 no 746 0.218923946177988 973 743552
SGTC_315 k915-0449 187 µM 0.774913997313657 0.22001883876 no 747 0.219195240251442 1103 20970215 YNL149C PGA2
SGTC_1170 0310-0127 64.8 µM 0.773621567459168 0.220406055292487 no 748 0.219577307055565 1073 774975
SGTC_618 k072-0232 33.2 µM 0.773345717536632 0.220488751452471 no 749 0.219658903031956 1051 5872756 YGL099W LSG1
SGTC_1870 st057514 26.5 µM 0.773274676941488 0.220510051362571 no 750 0.219679919548115 1083 5393161
SGTC_2256 7954252 200 µM 0.773075940424875 0.220569644259192 no 751 0.219738719518276 967 2972920
SGTC_3353 9151644 39.2805 µM 0.772469268488566 0.220751617254204 no 752 0.219918270805373 1052 4909158
SGTC_2319 6033012 152.6 µM 0.772245372479767 0.220818797221641 no 753 0.219984556575681 1011 847246
SGTC_1308 1187-1617 41.4 µM 0.771608822309141 0.221009857955045 no 754 0.220173073724078 1104 2882570
SGTC_3182 9108849 49.47 µM 0.770150689774928 0.221447873303561 no 755 0.220605255138779 1130 17133045
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.76926830329413 0.221713178429251 no 756 0.220867024874472 1040 77254
SGTC_982 1491-0518 27.5 µM 0.767986675467764 0.222098845788784 no 757 0.221247550536659 1022 3091256
SGTC_1328 1441-0025 69.2 µM 0.767149369571372 0.222351014495337 no 758 0.221496355818905 1056 4562601
SGTC_78 0336-0123 156.75 µM 0.766681214226846 0.222492078484015 no 759 0.221635537773665 978 6765896
SGTC_1395 3486-0190 4.35 µM 0.766520060408715 0.222540648957857 no 760 0.221683460147919 1131 6748079
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.765675425753747 0.222795313956805 no 761 0.221934726301814 1072 641818 YHR062C RPP1
SGTC_1567 st069303 68.4 µM 0.764912292651222 0.22302554823189 no 762 0.222161886746738 1098 5581319
SGTC_964 1287-0107 19.4 µM 0.76454528190909 0.223136322172643 no 763 0.222271181405156 1101 51516812 YPR165W RHO1
SGTC_2708 st078559 56 µM 0.763951871761092 0.22331549593865 no 764 0.222447961989348 1010 17250902
SGTC_286 k060-0067 22.9 µM 0.763046160905026 0.223589123309413 no 765 0.222717933433298 1067 5985051
SGTC_823 0417-1665 178 µM 0.762790565766911 0.223666376504458 no 766 0.22279415419981 1092 3429856
SGTC_2849 9019321 12.99 µM 0.761810020635176 0.223962885356723 no 767 0.223086699420505 1042 16489627
SGTC_1723 st034307 2.5525 µM 0.759327780965188 0.224714491859696 no 768 0.223828251471864 1123 867466
SGTC_2506 ethyl hematommate 54.16 µM 0.757518978727577 0.225263085565421 no 769 0.224369499997529 1057 3940691 An allergen.
SGTC_3307 9126885 69.2785 µM 0.757489402893036 0.225272061952294 no 770 0.224378356153388 1095 24824909
SGTC_1643 st009866 20.2 µM 0.75613686840779 0.225682778108161 no 771 0.22478356956918 1114 3156273 YOR207C RET1
SGTC_1734 st037168 69.4 µM 0.755418145092419 0.225901200832991 no 772 0.22499906465436 1021 708907
SGTC_3345 9148410 3.559 µM 0.75522157093486 0.225960961271419 no 773 0.225058023942513 1073 4903596
SGTC_2640 pentamidine 10.38 µM 0.754698575312567 0.226120000497453 no 774 0.225214930774057 1128 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1935 st074532 41.6 µM 0.75264774597048 0.226744253059748 no 775 0.225830809038899 1188 2829742
SGTC_447 ml7 120 µM 0.751904939774562 0.226970595729589 no 776 0.226054113643547 1148 4216 Selective myosin light chain kinase inhibitor.
SGTC_1075 aripiprazole 15.2 µM 0.75059022745773 0.227371517769614 no 777 0.226449652140415 1172 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1859 st055998 20 µM 0.749808169984802 0.227610195633341 no 778 0.226685123730456 1135 676301
SGTC_2581 avocatin a 64 µM 0.749352043756877 0.227749466919182 no 779 0.226822523661994 1104 6710728 A skin care supplement.
SGTC_2356 9061756 188.97 µM 0.749149592420347 0.227811297756541 no 780 0.22688352358586 1096 20104043
SGTC_2681 menadione 3.18 µM 0.748904123768795 0.227886279218125 no 781 0.226957497320689 1136 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1496 4469-0713 57.4 µM 0.74556871836349 0.228906495556637 no 782 0.227963992685051 1096 746691
SGTC_1658 st012944 20 µM 0.742140359828962 0.229957809972166 no 783 0.229001149404593 1078 24207260
SGTC_3150 9097574 49.47 µM 0.74209631462171 0.229971334101013 no 784 0.229014491287761 1098 17217476
SGTC_948 3448-0295 75.3 µM 0.741907857297321 0.230029205154606 no 785 0.229071582460048 1152 678569
SGTC_816 0325-0417 81.3 µM 0.741853705094884 0.230045835598956 no 786 0.229087988779048 1122 68101
SGTC_537 1334-0398 209 µM 0.741799951045137 0.230062344433763 no 787 0.229104275122859 1130 5846986
SGTC_1724 st037281 8.293 µM 0.74056703980071 0.230441175558678 no 788 0.229477999463464 1137 574124 YDL195W SEC31
SGTC_713 1488-1073 324 µM 0.740069797413886 0.230594059626895 no 789 0.229628821924257 1123 3312542
SGTC_1461 k072-0203 53.8 µM 0.740020319225246 0.230609275482105 no 790 0.229643832575943 1104 5418714
SGTC_1017 4239-0030 168 µM 0.73972947112537 0.230698730327373 no 791 0.229732080941256 1129 1149593
SGTC_865 0488-0499 301 µM 0.738173254230267 0.231177698184067 no 792 0.2302045867075 1162 9634651
SGTC_820 1582-0060 59.9 µM 0.737577300239285 0.231361265969458 no 793 0.230385676856025 1110 3848840
SGTC_3132 9126706 49.47 µM 0.734659883449278 0.232261070726168 no 794 0.231273328928961 1138 850858
SGTC_1140 3229-1848 2.98 µM 0.734331168911746 0.232362576477378 no 795 0.231373462933346 1144 2849525
SGTC_2151 5563267 85.4165 µM 0.733879280669107 0.23250215805328 no 796 0.231511157937001 1113 5310824
SGTC_442 cape 100 µM 0.732819566375664 0.23282967088492 no 797 0.231834242913244 1090 5281787
SGTC_2997 9067075 71.4286 µM 0.732503618692542 0.232927366520979 no 798 0.231930617409063 1143 27209819
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.731967546790788 0.233093179860136 no 799 0.232094188104367 1188 91467 include heat shock
SGTC_652 0437-0092 114 µM 0.730776790401154 0.233461729167544 no 800 0.232457751185658 1121 3091274
SGTC_2585 alliin 100 µM 0.729764266819799 0.23377536800903 no 801 0.232767145020979 1186 87310 A garlic compound which reacts with lipids.
SGTC_1479 0549-0158 134 µM 0.728303963076506 0.234228122032354 no 802 0.233213768446566 1208 5440202
SGTC_920 mycophenolic acid 780.421 nM 0.727208281161493 0.234568146842844 no 803 0.233549186997749 1115 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_3207 9114163 49.47 µM 0.725018134436825 0.235248636336896 no 804 0.234220452671181 1186 849233
SGTC_2017 5132927 60.65 µM 0.724325311417996 0.235464126618859 no 805 0.234433020575441 1161 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_2905 7799065 20.05 µM 0.724100742129907 0.235533998271681 no 806 0.234501944510372 1109 1296806
SGTC_1123 mangostin 811.285 nM 0.723045974321733 0.235862327797479 no 807 0.234825819684652 1093 5281650 An antioxidant.
SGTC_3346 9158254 43.5805 µM 0.72279612891093 0.235940136952509 no 808 0.234902572986927 1116 17639500
SGTC_121 0557-0495 61.343 µM 0.722201898695338 0.236125254414036 no 809 0.23508517808003 1294 3104427
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.721589281791927 0.23631618351785 no 810 0.235273515402709 1180 165521
SGTC_2355 9061122 103.12 µM 0.721077218656771 0.236475839081659 no 811 0.23543100329184 1144 5302957
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.720739598085258 0.236581137869114 no 812 0.235534872209114 1216 368090
SGTC_2090 5301565 104.445 µM 0.720130220881709 0.236771258757704 no 813 0.235722410996069 1164 2056344
SGTC_2793 7325131 81.82 µM 0.719764753626713 0.236885321957957 no 814 0.235834924804697 1120 4176441
SGTC_909 3448-9333 149 µM 0.71852844715164 0.237271400009691 no 815 0.236215757090733 1111 3344074
SGTC_20 0481-0013 4.944 µM 0.718437120265576 0.237299933585808 no 816 0.236243902884916 1155 182045
SGTC_2935 9038016 29.96 µM 0.717903322081827 0.237466747696505 no 817 0.236408449690512 1168 6463195
SGTC_1227 3909-8010 46.6 µM 0.717822970990942 0.237491863313247 no 818 0.236433223905321 1126 15982272
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.717432551459656 0.237613918840471 no 819 0.236553620174326 1155 97141
SGTC_314 1671-0008 2.74 µM 0.714360323932219 0.238575578976513 no 820 0.23750219965 1119 3913060
SGTC_3124 9127567 49.47 µM 0.713765033306052 0.238762161263024 no 821 0.237686242468301 1127 17592030
SGTC_565 1418-0001 44.5 µM 0.713665005410218 0.238793520896484 no 822 0.237717175234213 1185 2862145
SGTC_2152 5568786 200 µM 0.713311975301408 0.238904216976424 no 823 0.237826364405973 1153 5399883
SGTC_1726 st035556 14.5795 µM 0.711749675494311 0.23939442823767 no 824 0.238309900313567 1182 5919439
SGTC_1026 k007-1105 30.6 µM 0.711479168330763 0.239479362493976 no 825 0.238393677648366 1152 7066794
SGTC_2033 5192550 145 µM 0.710953414722111 0.239644486479755 no 826 0.238556552126738 1167 182073
SGTC_501 nsc-95397 161 µM 0.709213254100606 0.240191463499466 no 827 0.239096074865954 1173 262093
SGTC_1145 3546-0597 10.2 µM 0.709093112387213 0.240229252207938 no 828 0.239133348430079 1143 875334
SGTC_584 0986-0246 15.4 µM 0.708745099594076 0.240338732504889 no 829 0.23924133615428 1276 53315 YDR232W HEM1
SGTC_2980 9014342 25.29 µM 0.708389779557763 0.240450539603184 no 830 0.239351618786022 1181 2996599
SGTC_2393 9031399 185.94 µM 0.708012490617637 0.240569290568733 no 831 0.239468750416978 1197 1526623 YDL150W RPC53
SGTC_1826 st055655 41.6 µM 0.706434131962815 0.24106642193006 no 832 0.23995910058716 1174 676168
SGTC_3303 9125618 40.5795 µM 0.70630120361034 0.241108315501672 no 833 0.240000422548295 1197 22695467
SGTC_1620 st003704 16.5 µM 0.705536653637537 0.241349347169763 no 834 0.240238165029841 1166 2834414
SGTC_529 4076-0302 30.3 µM 0.703750904402065 0.241912831271169 no 835 0.240793956582213 1133 5816522
SGTC_1327 1436-0082 2.18 µM 0.702414793647101 0.242334900555971 no 836 0.241210261069854 1145 15992205
SGTC_2258 7960471 200 µM 0.701764378280852 0.242540507141145 no 837 0.24141305853012 1148 2974708
SGTC_1185 1319-0113 81.3 µM 0.701425227985741 0.242647755377979 no 838 0.241518841251068 1185 4672763
SGTC_911 3456-4043 236 µM 0.700397200425422 0.242973001527215 no 839 0.24183964207187 1224 914281
SGTC_1556 plumbagin 1.48 µM 0.70014814158541 0.243051833943694 no 840 0.241917396828866 1124 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1689 st020265 53.493 µM 0.699622438946292 0.243218275407115 no 841 0.242081562725137 1176 5758320 YPR016C TIF6
SGTC_887 0885-0007 9.62 µM 0.697354888925969 0.243936904582266 no 842 0.242790362719743 1201 5719458
SGTC_430 0958-0115 16.4 µM 0.69523805415717 0.244608801838551 no 843 0.243453063913777 1139 6833180
SGTC_1774 st048371 48.465 µM 0.694687336941469 0.244783766338747 no 844 0.243625632773467 1181 4242727
SGTC_63 0099-0242 26.702 µM 0.693694844017173 0.245099254330277 no 845 0.243936800068544 1210 3898502 YLR359W ADE13
SGTC_3284 9108171 64.8615 µM 0.693235676558376 0.245245285823305 no 846 0.24408083119125 1147 8687505
SGTC_932 2857-0803 154 µM 0.692698957978955 0.245416040593599 no 847 0.244249246584357 1246 674898
SGTC_311 1315-0136 58 µM 0.691775793216986 0.245709890989214 no 848 0.244539070306011 1224 6759207
SGTC_1900 st060200 72.8 µM 0.690811103632591 0.246017160799969 no 849 0.244842128396834 1217 688945
SGTC_344 k064-0035 6.43 µM 0.690207169702916 0.246209628761517 no 850 0.245031957617418 1176 5088750
SGTC_2716 st080858 38.6235 µM 0.689990012843836 0.246278854303887 no 851 0.245100233963191 1193 5296050
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.689389876926899 0.246470220656753 no 852 0.245288976058233 1224 551469
SGTC_1871 st057448 67.3 µM 0.689095604123694 0.246564085027437 no 853 0.245381553076351 1287 691747
SGTC_7 0192-1582 4.227 µM 0.688292456018798 0.246820363077992 no 854 0.245634315713573 1244 252616
SGTC_3084 9116877 49.47 µM 0.687190157671918 0.24717232957291 no 855 0.245981452907311 1135 27241325
SGTC_1416 3966-0321 25.3 µM 0.685952673600063 0.247567780787152 no 856 0.246371476371466 1226 582530 YLR208W SEC13
SGTC_2699 st077704 54.6 µM 0.685354409647901 0.247759083535137 no 857 0.24656015272225 1208 645852
SGTC_786 4544-0069 423 µM 0.684945537650241 0.24788987111142 no 858 0.246689144461154 1210 748821 YLR208W SEC13
SGTC_2342 7990637 118.86 µM 0.684259425924263 0.248109423280551 no 859 0.246905681509686 1244 2033102 YER133W GLC7
SGTC_641 4092-0595 30 µM 0.684185452246542 0.248133100664086 no 860 0.246929033696117 1218 786260
SGTC_2156 5649887 115 µM 0.683568361311733 0.248330665156258 no 861 0.247123884477464 1263 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1264 0783-0040 158 µM 0.680906742253267 0.249183754679965 no 862 0.247965250809121 1164 2855798
SGTC_2728 chlorpromazine 9.18 µM 0.680873160577816 0.249194528067042 no 863 0.24797587609317 1217 2726 A thorazine and dopamine antagonist.
SGTC_3190 9110366 49.47 µM 0.680692375689204 0.249252530191206 no 864 0.248033080831973 1147 17123768
SGTC_354 2783-3500 4.88 µM 0.68000796519385 0.249472178064665 no 865 0.248249708736518 1198 6740761
SGTC_1021 4476-0760 85.3 µM 0.679379482676412 0.249673967530327 no 866 0.248448723277055 1201 746768
SGTC_544 k015-0020 52.4 µM 0.678782053015097 0.249865867067759 no 867 0.248637983454638 1219 3008304
SGTC_1350 1495-0454 146 µM 0.678392441124311 0.249991055918745 no 868 0.24876145024664 1240 1069057
SGTC_1969 st069479 40.1 µM 0.675180359568809 0.251024418767557 no 869 0.249780591643069 1199 3895485
SGTC_2575 plumbagin 510 nM 0.675098378689799 0.251050822486882 no 870 0.249806631828023 1199 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.67508687827553 0.25105452656213 no 871 0.249810284903819 1244 2724 A muscle relaxant with antifungal properties.
SGTC_2157 5649910 96.377 µM 0.675058990853621 0.251063508715954 no 872 0.249819143386481 1204 2858091
SGTC_482 fipronil 114 µM 0.674798881695694 0.251147294474498 no 873 0.249901775493666 1253 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1194 1488-0194 225 µM 0.67405381589525 0.251387375174205 no 874 0.250138550071809 1203 1391452
SGTC_16 erodoxin 22.806 µM 0.672011548250967 0.25204607147335 no 875 0.250788172254162 1260 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3127 9126946 49.47 µM 0.671301670427058 0.252275242745535 no 876 0.251014185369727 1178 27243249
SGTC_331 k048-0133 24.5 µM 0.669941659936661 0.252714604324803 no 877 0.251447490603574 1217 6813582
SGTC_809 3998-0021 90 µM 0.669793987928167 0.25276233511395 no 878 0.251494563325039 1179 715485
SGTC_3249 9135183 49.47 µM 0.669197747688463 0.252955101126776 no 879 0.251684671408875 1265 4902779
SGTC_306 1672-3436 11.6 µM 0.66546848345004 0.254162534912189 no 880 0.252875447605898 1257 6797378
SGTC_2047 4141938 200 µM 0.663854166223985 0.25468614254436 no 881 0.253391826839218 1232 3807862
SGTC_985 1493-0307 8.71 µM 0.663291168045454 0.254868885106952 no 882 0.253572045971128 1231 3278274
SGTC_1657 st012939 43.4 µM 0.663014708915496 0.254958645594362 no 883 0.253660566859685 1277 24207257
SGTC_1632 st005650 90 µM 0.662396920042403 0.255159288465016 no 884 0.253858438537628 1243 2759605
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.661419781588408 0.255476807889656 no 885 0.254171571677596 1211 279621
SGTC_2185 6113692 200 µM 0.661337466696309 0.255503565394153 no 886 0.254197959500884 1247 874150
SGTC_2243 6634756 200 µM 0.660649711005499 0.255727186352794 no 887 0.254418490631698 1304 885676
SGTC_269 exalamide 29 µM 0.659985454148552 0.255943263729531 no 888 0.254631581930964 1243 3316 A derivative of salicylamide.
SGTC_1583 clindamycin 39.6 µM 0.659983365078171 0.255943943437452 no 889 0.25463225224493 1187 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_986 1493-0483 84 µM 0.658776128420609 0.2563368920535 no 890 0.255019769307409 1214 40079
SGTC_750 4073-0104 132 µM 0.658075423349058 0.256565111671515 no 891 0.255244833638481 1134 22330957
SGTC_3183 9108214 49.47 µM 0.656978343811449 0.256922642886168 no 892 0.255597420708648 1178 4974831
SGTC_1919 st067113 52.3 µM 0.655548272560405 0.257389082882481 no 893 0.256057408616272 1258 1268243
SGTC_2738 aclarubicin 5.55 µM 0.65505873128717 0.257548855423287 no 894 0.256214970595037 1179 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1865 st057639 52.2 µM 0.653675707294277 0.258000513832414 no 895 0.256660378664651 1259 688818
SGTC_3296 9122258 64.045 µM 0.653223801763945 0.258148183018214 no 896 0.256806003883242 1264 4730474
SGTC_2941 9056145 11.23 µM 0.652247932414761 0.258467217304961 no 897 0.257120621536326 1163 2119517
SGTC_1388 3346-4487 254 µM 0.651364076722059 0.25875634635449 no 898 0.257405747117821 1318 3345614
SGTC_1756 st041558 35.5 µM 0.650765795640209 0.258952152494871 no 899 0.257598841551458 1333 3955792
SGTC_2468 5987765 72.9 µM 0.650728222307083 0.258964452097124 no 900 0.257610970805272 1305 26772094
SGTC_1520 flindersine 88 µM 0.650308765227712 0.259101781569249 no 901 0.257746398179639 1361 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1189 1431-2119 7.28 µM 0.64919400808935 0.259466933918173 no 902 0.258106492087169 1286 3107275
SGTC_2232 chlorophetanol 41.5365 µM 0.648210190977782 0.259789415910302 no 903 0.258424505720515 1326 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1805 st050013 60.3 µM 0.646907138848173 0.260216856981382 no 904 0.258846022631316 1232 4037144
SGTC_2877 9040724 71.43 µM 0.646237508691229 0.260436657115963 no 905 0.259062775776542 1283 6463895
SGTC_31 0508-1974 57.237 µM 0.645820544405086 0.260573570220386 no 906 0.259197790695671 1235 6810525
SGTC_2456 5770359 74.46 µM 0.644907353463806 0.260873552165325 no 907 0.25949361305243 1283 3118787
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.644455154665104 0.261022164569948 no 908 0.259640164479579 1323 165506
SGTC_1458 k015-0034 6.33 µM 0.643686367093457 0.261274921830797 no 909 0.259889416015624 1236 3598957
SGTC_2173 5763948 167 µM 0.642944907992088 0.261518813268094 no 910 0.260129924159695 1282 2867177
SGTC_2124 5246320 200 µM 0.642870228162481 0.261543384513647 no 911 0.260154154520684 1286 579342
SGTC_946 3434-1334 87.4 µM 0.64260765736085 0.2616297852759 no 912 0.260239356576003 1257 4047976
SGTC_2436 5633522 8.09 µM 0.641852650904584 0.261878307033741 no 913 0.260484430027578 1269 5724242
SGTC_2694 st077685 81.9 µM 0.640883862990032 0.262197375427753 no 914 0.260799070472053 1248 2838096
SGTC_616 4092-0450 108 µM 0.640358037883775 0.262370638246012 no 915 0.260969928423633 1307 787165
SGTC_492 tmb-8 126 µM 0.63901961665721 0.262811921212188 no 916 0.261405085270684 1187 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2709 st078560 56 µM 0.636674076093932 0.263586169974169 no 917 0.262168581512866 1311 17250903
SGTC_629 3448-6466 76.7 µM 0.634519413031116 0.264298435442671 no 918 0.262870950844844 1275 573744
SGTC_3265 9137266 49.47 µM 0.631690738030311 0.265234994026271 no 919 0.263794490678536 1255 17224265
SGTC_84 0443-0269 128.823 µM 0.630687644129128 0.265567517101559 no 920 0.264122389781454 1251 6150058
SGTC_1977 st070720 65.3 µM 0.630217685064922 0.265723380043632 no 921 0.264276085035738 1296 682188
SGTC_2254 7938975 95.19 µM 0.630007539844197 0.265793090163921 no 922 0.264344825589857 1363 2969277
SGTC_1357 1503-1303 39.5 µM 0.628359663805751 0.266340050618064 no 923 0.26488417730147 1290 292895
SGTC_2273 7815444 169.05 µM 0.62833902055832 0.266346906103246 no 924 0.264890937405533 1286 2824616
SGTC_2109 5483026 200 µM 0.628126942285231 0.266417341057769 no 925 0.264960392369732 1329 759335
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.626553401843571 0.266940235910826 no 926 0.265476010779723 1315 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1250 0485-0349 40.2 µM 0.626247896436475 0.267041816848546 no 927 0.265576177906168 1302 6842794 YDL195W SEC31
SGTC_1811 st050069 61.5 µM 0.626146585055394 0.267075507321364 no 928 0.2656093994551 1290 3877702
SGTC_2094 5332512 191.667 µM 0.626040644008171 0.267110739656319 no 929 0.265644141396417 1365 755774
SGTC_345 1362-0200 395 µM 0.625656360868654 0.267238558651769 no 930 0.265770181219399 1278 1419823
SGTC_2408 sulbentine 18.36 µM 0.625615164029034 0.267252263240944 no 931 0.265783695040652 1361 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_2531 methyl deoxycholate 70.07 µM 0.625463122021473 0.26730284478386 no 932 0.265833572476081 1284 16667744 Haematoxylin.
SGTC_380 3970-0968 6 µM 0.624507388613245 0.267620910054813 no 933 0.266147209759981 1276 2891601
SGTC_1326 1431-2094 10.8 µM 0.622195102387486 0.268391220424259 no 934 0.266906793038489 1278 616278
SGTC_3251 9135047 49.47 µM 0.616794012802692 0.270194861867873 no 935 0.268685300792953 1363 17682963
SGTC_68 0986-0284 82.829 µM 0.61514695328758 0.27074608504939 no 936 0.269228838152843 1277 423278 YIL048W NEO1
SGTC_206 4546-0025 72.014 µM 0.614741651279742 0.270881813935411 no 937 0.269362674224159 1320 6620745 YIL048W NEO1
SGTC_2902 5787006 60.46 µM 0.61468909871914 0.270899415398499 no 938 0.269380030215928 1313 591003
SGTC_585 0kpi-0023 191 µM 0.614592468463991 0.270931781321783 no 939 0.269411944756161 1311 64601
SGTC_54 0159-0055 9 µM 0.611536156496704 0.271956475532211 no 940 0.270422344711528 1409 3319099
SGTC_2819 7996655 46.38 µM 0.608278705383961 0.273050723874647 no 941 0.271501320960848 1262 6456960
SGTC_141 0443-0274 32.331 µM 0.607878638897795 0.273185265193533 no 942 0.271633984000315 1394 1627241
SGTC_706 4262-0057 46.9 µM 0.604706043886573 0.274253362276435 no 943 0.272687165801016 1293 883298
SGTC_628 1636-0253 16 µM 0.604478589170261 0.274330017137726 no 944 0.272762749958204 1317 4456143
SGTC_146 3448-8650 53.125 µM 0.604138521910961 0.274444643449979 no 945 0.272875775120387 1352 2891488 YIL048W NEO1
SGTC_867 0518-0118 155 µM 0.60403191281013 0.274480582995784 no 946 0.272911212630728 1356 6848158
SGTC_1315 1237-0019 3.69 µM 0.60307023475528 0.274804884188039 no 947 0.273230983346353 1346 825140
SGTC_2130 NSC 7 2.4545 µM 0.602442733074692 0.275016594777418 no 948 0.273439736008433 1350 21448
SGTC_700 3453-2283 142 µM 0.6013499648475 0.275385471703917 no 949 0.273803458518283 1402 565664
SGTC_1460 k062-0059 9.15 µM 0.599674483704591 0.275951522684958 no 950 0.274361598379749 1303 1373085
SGTC_2149 5554786 194.827 µM 0.599401774034831 0.276043710015852 no 951 0.274452497127901 1351 745063 YPR165W RHO1
SGTC_2863 9028737 58.44 µM 0.599108658913032 0.276142812105809 no 952 0.274550213927613 1354 6460917
SGTC_472 calcifediol 10 µM 0.598816958787929 0.276241453120867 no 953 0.274647476042273 1344 5283731 A vitamin D metabolite.
SGTC_3295 9122362 53.5725 µM 0.59847278360082 0.276357861280523 no 954 0.274762256864403 1341 4730473
SGTC_687 k029-0044 34.9 µM 0.592157299437518 0.278498168346321 no 955 0.276872630090363 1388 5829338
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.590947154118345 0.278909204627994 no 956 0.277277914934397 1358 3256 An antibiotic and ribosome inhibitor.
SGTC_874 0599-0792 117 µM 0.590316639357579 0.279123481285779 no 957 0.277489192977031 1368 765305
SGTC_1008 4106-0037 6 µM 0.588221157046793 0.279836192840235 no 958 0.278191929095179 1341 2905394
SGTC_496 calpeptin 138 µM 0.587615520769036 0.280042345035806 no 959 0.278395195422075 1303 73364 A calpain inhibitor.
SGTC_3246 9135460 32.98 µM 0.587417082414913 0.280109907365123 no 960 0.278461811919552 1344 41446951
SGTC_1396 3511-0007 98.6 µM 0.586168718780926 0.280535118940688 no 961 0.278881070283377 1325 X1396
SGTC_2078 5212016 200 µM 0.586121771578653 0.280551115962215 no 962 0.278896843320276 1310 1899708
SGTC_1548 st061468 90.8 µM 0.585740616165939 0.280681009077969 no 963 0.279024917673545 1357 390799
SGTC_493 zm226600 134 µM 0.585514349401766 0.280758131789566 no 964 0.279100960475603 1386 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2534 helenine 20.12 µM 0.585071231153201 0.280909197707994 no 965 0.279249911014548 1391 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_71 0417-1750 47.813 µM 0.58311453121195 0.281576736610435 no 966 0.279908101081081 1447 6811472
SGTC_2100 5377183 190 µM 0.580331489052547 0.282527502620785 no 967 0.280845548184602 1405 2844202
SGTC_1053 3366-3204 134 µM 0.580323965370973 0.282530075014102 no 968 0.280848084536835 1316 3632071 YPR165W RHO1
SGTC_3128 9127691 49.47 µM 0.579411279661964 0.282842211418831 no 969 0.281155847471946 1372 41316314
SGTC_1641 st009299 47.1 µM 0.578631988954651 0.283108858059073 no 970 0.281418757685314 1325 4046054
SGTC_1834 st055981 52.8 µM 0.577880821592237 0.283365995976261 no 971 0.281672292131378 1440 471719 YDL150W RPC53
SGTC_3333 9141820 12.094 µM 0.575368610592052 0.284226782927283 no 972 0.282521014209436 1368 1939433
SGTC_1184 1269-1718 139 µM 0.575155663257759 0.284299804890781 no 973 0.282593012550699 1466 5403821
SGTC_2407 paclitaxel 400 µM 0.574420372729316 0.284552012946047 no 974 0.282841684987809 1518 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1852 st056254 31.4 µM 0.572583786210943 0.285182436966982 no 975 0.28346327021284 1387 442583
SGTC_2010 4012422 159 µM 0.572050792251308 0.285365516235833 no 976 0.283643782348736 1419 952393
SGTC_3218 9131285 49.47 µM 0.571524987175958 0.285546181011031 no 977 0.283821913721714 1478 17156417
SGTC_3209 9113616 49.47 µM 0.57128670184914 0.285628072934533 no 978 0.283902657261272 1422 16649353
SGTC_2792 7535235 81.82 µM 0.571066110572534 0.285703893874183 no 979 0.283977414928903 1340 1281891
SGTC_2757 clomiphene 4.22 µM 0.570180970614457 0.286008227650561 no 980 0.284277480676549 1475 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1195 1502-0147 41.1 µM 0.568742961863587 0.286502980079274 no 981 0.284765293886842 1369 817940
SGTC_968 1309-0633 340 µM 0.568180541872084 0.286696593239541 no 982 0.28495619125857 1373 3761976
SGTC_3339 9145883 14.936 µM 0.568053501574371 0.286740335467352 no 983 0.284999319900921 1362 2030670
SGTC_2576 guaiol 23.12 µM 0.567105623168315 0.287066806645132 no 984 0.285321211355773 1392 227829
SGTC_2695 st077686 51.995 µM 0.566915923502371 0.287132164716637 no 985 0.28538565254244 1340 2876092
SGTC_91 0417-1751 58.384 µM 0.566221554903458 0.287371458695191 no 986 0.285621589426044 1436 6795624
SGTC_1135 dihydrocapsaicin 536.708 nM 0.566213622003295 0.2873741930839 no 987 0.285624285452422 1324 107982 A Capsaicinoid.
SGTC_1068 loratadine 26.9 µM 0.565957970048595 0.287462320259816 no 988 0.285711176227255 1377 3957 A H1 histamine antagonist.
SGTC_224 benfluorex 43.875 µM 0.565264127602883 0.287701562855587 no 989 0.285947062179528 1398 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_220 paclitaxel 373.376 µM 0.564077182372286 0.28811104936244 no 990 0.286350803026816 1405 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2780 5215298 71.43 µM 0.561628961208578 0.288956533413591 no 991 0.287184422049089 1417 2834131
SGTC_160 3453-0671 289.699 µM 0.561217399548562 0.289098779237626 no 992 0.287324671456506 1328 5322268
SGTC_1985 st071382 65.5 µM 0.559457643797441 0.289707365199098 no 993 0.287924715230858 1406 6123237
SGTC_2791 5663188 71.43 µM 0.558896721159908 0.289901478433623 no 994 0.288116103634871 1464 54690634
SGTC_2833 9001315 45.46 µM 0.558808556133473 0.289931994423496 no 995 0.2881461912518 1442 2989378
SGTC_2799 7812892 81.82 µM 0.557308827749359 0.290451316294341 no 996 0.288658222648007 1434 20205235
SGTC_1212 0520-0165 585 µM 0.556601714727199 0.290696324426998 no 997 0.288899790979709 1608 5403258
SGTC_1010 4112-3296 15.2 µM 0.555461093232711 0.291091742831327 no 998 0.289289657541639 1444 704384
SGTC_1353 1498-1206 8.11 µM 0.555100058134354 0.291216954922107 no 999 0.289413111512762 1422 6756808
SGTC_3222 9128301 49.47 µM 0.554865779997182 0.291298219351536 no 1000 0.289493234874996 1405 4911358
SGTC_161 4065-0411 162.148 µM 0.554508854306964 0.29142204707381 no 1001 0.289615323847613 1449 1906281 YLR208W SEC13
SGTC_1779 st039427 55 µM 0.554391784456979 0.291462667297957 no 1002 0.289655373686597 1547 1124498
SGTC_858 0438-0351 2.77 µM 0.549260888309109 0.293245544807213 no 1003 0.291413212104808 1397 2799119
SGTC_3216 9129716 49.47 µM 0.54712569510718 0.293988965866242 no 1004 0.292146190191201 1356 8056934
SGTC_586 0957-0265 8.15 µM 0.544656084637925 0.29484990783032 no 1005 0.292995036860957 1345 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2844 9010103 25.97 µM 0.544132363101634 0.295032633992925 no 1006 0.293175195726328 1414 2480525
SGTC_1421 4029-0249 71.4 µM 0.543620679255031 0.29521121057426 no 1007 0.293351263248679 1499 2894095
SGTC_3015 9080845 49.47 µM 0.542418010049225 0.295631135383287 no 1008 0.293765287737466 1516 5296973
SGTC_369 0957-0393 4.5 µM 0.541351196313268 0.296003854437282 no 1009 0.294132769480938 1380 6997992
SGTC_1634 st006576 41 µM 0.540262506103122 0.296384438844986 no 1010 0.29450800580212 1517 3915356
SGTC_1370 2001-0092 44.6 µM 0.539270998852886 0.29673124508037 no 1011 0.294849938396285 1594 790957
SGTC_394 menadione 8.33 µM 0.538436842156514 0.297023157573409 no 1012 0.295137748512055 1418 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1887 st057648 70.8 µM 0.536095817280752 0.297843098137611 no 1013 0.295946165373731 1521 688672
SGTC_379 3970-0972 5.9 µM 0.535624340673998 0.298008356930118 no 1014 0.296109101446844 1448 2898042 YBL034C STU1
SGTC_268 camptothecin 39.6153 µM 0.535604873155941 0.298015181451238 no 1015 0.296115830048197 1438 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_943 3253-1379 105 µM 0.534413381969892 0.298433005376268 no 1016 0.296527781266614 1503 668464
SGTC_2255 7941087 197.44 µM 0.533795584838373 0.298649755111993 no 1017 0.296741484393266 1526 935561
SGTC_1917 st066507 28.5 µM 0.531312046816954 0.299521808142096 no 1018 0.29760127935424 1442 3156428
SGTC_2963 9082507 9 µM 0.531215038083668 0.299555894554263 no 1019 0.297634886610342 1484 16459611
SGTC_3037 9091026 49.47 µM 0.530267585073579 0.299888897938743 no 1020 0.297963208865788 1448 25236398 YIL048W NEO1
SGTC_367 0335-0881 7.1 µM 0.527505812021247 0.300860539088883 no 1021 0.29892119071443 1508 23828853
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.525370461923726 0.301612765358991 no 1022 0.299662841628131 1490 676296 Flavone; oxidizing agent.
SGTC_2041 5107442 45.335 µM 0.524240844646121 0.302011040890744 no 1023 0.300055517729835 1491 793005
SGTC_1114 scopoletin 1.73284 µM 0.523809808987088 0.302163075799598 no 1024 0.30020541512261 1504 5280460 A coumarin with genotoxic properties.
SGTC_535 2293-4129 48.2 µM 0.522820972481999 0.302511987977276 no 1025 0.300549421756834 1550 396118 YIL048W NEO1
SGTC_100 0086-0128 49.5915 µM 0.522432325871603 0.302649171839296 no 1026 0.300684676857401 1361 93297
SGTC_3143 9086658 49.47 µM 0.520133210155735 0.303461279571792 no 1027 0.301485366413004 1483 25236626
SGTC_2403 6032726 181.2 µM 0.519687667449881 0.303618769429468 no 1028 0.301640641939845 1462 2881040
SGTC_1282 0886-0010 32.4 µM 0.519430650467476 0.303709636052038 no 1029 0.301730230959777 1519 2836211 YNL267W PIK1
SGTC_793 0488-0545 106 µM 0.518021954788629 0.304207886323582 no 1030 0.302221475683506 1415 292548
SGTC_2927 9011802 47.9 µM 0.517527958140046 0.304382697241943 no 1031 0.302393828690443 1396 43912568
SGTC_1054 3429-0080 167 µM 0.517348440411895 0.304446234374687 no 1032 0.302456472463754 1509 1162877
SGTC_2900 5328528 85.29 µM 0.514123762267082 0.30558855605329 no 1033 0.303582732488462 1415 795359
SGTC_1916 st067606 49.2 µM 0.512164791704185 0.306283434958057 no 1034 0.304267840985622 1561 19590279
SGTC_1453 4237-0541 195 µM 0.510832336192695 0.30675647740359 no 1035 0.304734232196355 1492 739892
SGTC_508 roscovitine 141 µM 0.50949885876729 0.307230205066631 no 1036 0.30520129902909 1527 160355 A CDKinase inhibitor.
SGTC_3157 9099274 49.47 µM 0.508465242925878 0.30759762619157 no 1037 0.305563554081761 1456 17217662
SGTC_1515 3460-0031 42.1 µM 0.506395018569987 0.308334112670981 no 1038 0.306289685438262 1428 2876596
SGTC_1132 3456-3614 2.5 µM 0.504324248702281 0.309071565773992 no 1039 0.307016770073585 1679 3125502
SGTC_3030 9087619 49.47 µM 0.504183691964157 0.309121649496873 no 1040 0.307066149638365 1441 25236973
SGTC_180 1486-1293 102.781 µM 0.503258215525785 0.309451507407997 no 1041 0.307391369910759 1628 4140536
SGTC_912 3474-0017 2.18 µM 0.501649054288696 0.310025409540758 no 1042 0.307957203436043 1569 3360550
SGTC_1292 0kpi-0043 232 µM 0.501635349045916 0.310030299462124 no 1043 0.307962024610018 1459 3333905
SGTC_3144 9087057 49.47 µM 0.5009981982966 0.310257666849135 no 1044 0.308186195459728 1535 17249618
SGTC_2457 5731572 11.68 µM 0.500435444368183 0.310458546052616 no 1045 0.308384250554783 1606 2865357
SGTC_632 0781-2353 4.65 µM 0.49959616692178 0.310758237419945 no 1046 0.308679728701535 1502 6811515 YHR007C ERG11
SGTC_145 3737-0113 38.366 µM 0.498579161909109 0.311121560513586 no 1047 0.30903794411211 1475 6849351
SGTC_1603 st002045 67.8 µM 0.49690316777189 0.311720707859727 no 1048 0.309628668776598 1493 5887985
SGTC_1913 st060213 96.1 µM 0.494724836048934 0.312500179996024 no 1049 0.310397183832108 1565 688959
SGTC_2375 9072683 200 µM 0.494063880751339 0.312736855724033 no 1050 0.310630532735121 1622 16798029
SGTC_1587 estradiol valerate 56.1 µM 0.493580273720473 0.312910075286712 no 1051 0.310801317485637 1515 13791 A steroid.
SGTC_1296 1068-0102 11.9 µM 0.493176297479511 0.313054804167443 no 1052 0.310944012054229 1537 767053
SGTC_118 0083-0097 135.343 µM 0.493035891667698 0.313105112823844 no 1053 0.310993613577349 1526 5207356
SGTC_2883 9059145 45.46 µM 0.492447895953247 0.313315834727828 no 1054 0.311201373631595 1468 16476510
SGTC_1815 st051655 58.2 µM 0.492067309883691 0.313452259078655 no 1055 0.311335880470056 1505 5984156
SGTC_1703 st026983 48.3 µM 0.490466929479416 0.314026208368281 no 1056 0.311901762895108 1571 1104023
SGTC_468 gf-109203x 121 µM 0.488814882288768 0.314619159303902 no 1057 0.312486380397561 1494 2396 A protein kinase C inhibitor.
SGTC_2952 9073731 13.78 µM 0.488174621022857 0.314849089885051 no 1058 0.312713079639504 1456 16457353
SGTC_2596 sinensetin 100 µM 0.48719459632906 0.31520117530815 no 1059 0.313060217178232 1470 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2448 5185112 27.17 µM 0.485711410318239 0.315734346689339 no 1060 0.313585896250421 1481 5718189
SGTC_940 3232-1287 54.8 µM 0.485595596810365 0.315775995154947 no 1061 0.313626959477809 1489 1585493 YIL048W NEO1
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.485128613919932 0.315943953705229 no 1062 0.313792557929629 1581 688761
SGTC_302 1094-0063 18.9 µM 0.483632920709938 0.316482161534221 no 1063 0.314323203379507 1458 5440289
SGTC_1060 3448-7350 82 µM 0.482374141630435 0.31693541999245 no 1064 0.314770093503274 1611 570178
SGTC_1769 st044406 64.4 µM 0.482243960315406 0.316982311094403 no 1065 0.31481632580224 1513 670903
SGTC_689 0833-0039 98 µM 0.481102153286779 0.317393714052574 no 1066 0.315221948883658 1566 5374726
SGTC_2303 7774051 200 µM 0.478894061723379 0.318189948484301 no 1067 0.316006997850762 1591 2953184
SGTC_2789 5281112 71.43 µM 0.477598498739379 0.318657518203106 no 1068 0.316467999802604 1462 765948
SGTC_232 clozapine 119 µM 0.476716102370485 0.318976141193255 no 1069 0.316782147500223 1525 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1137 ixabepilone 100 µM 0.476555280704063 0.319034226436034 no 1070 0.316839416918216 1483 154225 A novel microtubule stabilizer.
SGTC_1611 st001856 99.4 µM 0.476286960292627 0.319131147749123 no 1071 0.316934976959444 1464 647478
SGTC_2783 7738165 71.43 µM 0.475303403547923 0.319486528729148 no 1072 0.317285366756591 1422 17201110
SGTC_2196 6573537 42.6665 µM 0.475258237602942 0.319502852177501 no 1073 0.317301460955821 1605 2903087
SGTC_1424 4048-1941 275 µM 0.473891223972471 0.319997070672663 no 1074 0.317788738870338 1626 X1424
SGTC_3041 9091929 49.47 µM 0.47294263749775 0.320340202478844 no 1075 0.318127052240881 1562 25236887
SGTC_507 nimesulide 162 µM 0.472857452862973 0.320371023806019 no 1076 0.318157440773318 1589 4495 A COX2 inhibitor.
SGTC_491 tetrandrine 80.3 µM 0.472335770129653 0.320559804989778 no 1077 0.318343571133966 1568 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2359 9039622 200 µM 0.472203860744619 0.320607546357792 no 1078 0.318390642142751 1573 6463596
SGTC_37 0566-0070 1.56 µM 0.472110087889768 0.320641486948554 no 1079 0.318424106161102 1615 1626686
SGTC_3242 9133940 49.47 µM 0.470309867716158 0.321293357612268 no 1080 0.319066824248769 1544 17248444
SGTC_1146 3579-1023 7 µM 0.469461816739056 0.32160063304667 no 1081 0.319369785780533 1625 X1146
SGTC_617 3770-0098 35 µM 0.469275845565971 0.321668032557806 no 1082 0.319436239090421 1538 5962639
SGTC_198 3454-2873 16.191 µM 0.468630079950617 0.321902115937765 no 1083 0.319667036341929 1530 710957
SGTC_3043 9092303 49.47 µM 0.468038780226258 0.322116517998737 no 1084 0.319878428699841 1448 25236084
SGTC_1186 1319-0216 26 µM 0.468014297992829 0.322125396400296 no 1085 0.319887182472202 1649 4565136
SGTC_1644 st010134 20.9 µM 0.467242133964335 0.322405471214162 no 1086 0.320163325893406 1519 3818134
SGTC_2886 9058944 51.95 µM 0.465241395135723 0.323131636288904 no 1087 0.320879298888849 1477 4949929
SGTC_1202 1988-0068 29.6 µM 0.46507111983739 0.32319346863087 no 1088 0.320940263455639 1474 2850480
SGTC_2661 dactinomycin 12.96 µM 0.464453220172585 0.323417888543767 no 1089 0.321161533882978 1533 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1311 1190-0148 100 µM 0.46332434378894 0.323828060063722 no 1090 0.321565949494417 1634 1961333
SGTC_2871 9038510 12.99 µM 0.462637793987987 0.324077619166478 no 1091 0.321812006805857 1671 4945164
SGTC_2680 butyl paraben 22.24 µM 0.462631299657358 0.324079980216821 no 1092 0.32181433472708 1553 7184 An antifungal and steroid mimetic.
SGTC_1602 st001878 87.6 µM 0.458904865457255 0.325435910632922 no 1093 0.323151242340711 1583 595405 YLR310C CDC25
SGTC_2580 diallyl disulphide 81.36 µM 0.458137843329858 0.325715293218802 no 1094 0.323426706129402 1553 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1225 1216-0074 20.6 µM 0.458097066448846 0.325730148662462 no 1095 0.323441353208615 1503 4241466
SGTC_1089 terbinafine 2.25 µM 0.457650581857891 0.325892825762053 no 1096 0.323601748626752 1592 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_252 miconazole 1.30953 nM 0.457402852312491 0.325983100566983 no 1097 0.323690757291766 1540 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1409 3909-8004 61.9 µM 0.457282642902323 0.326026909599831 no 1098 0.323733951895701 1554 2119279
SGTC_2311 7694451 200 µM 0.456097001413894 0.32645913252154 no 1099 0.324160113177823 1602 2163142
SGTC_1635 st007035 42.4 µM 0.455991641194156 0.326497552637161 no 1100 0.324197994508557 1560 3716403
SGTC_1005 4092-0690 4.4 µM 0.455608642089605 0.326637230623723 no 1101 0.32433571376351 1512 1529343
SGTC_1873 rapamycin 2 nM 0.454954927593461 0.326875693387569 no 1102 0.324570832678356 1541 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_2237 6667747 47.222 µM 0.453962597227811 0.327237811993601 no 1103 0.324927873860976 1544 729940 YDL015C TSC13
SGTC_27 0485-0001 32.618 µM 0.451011158551117 0.328315803609719 no 1104 0.325990753355439 1556 2054479
SGTC_2775 cyproheptadine 69.59 µM 0.450528482178195 0.328492234050383 no 1105 0.326164710876453 1564 2913 A selective serotonin reuptake inhibitor.
SGTC_236 1509-0011 5.31 µM 0.449467863842109 0.328880051234328 no 1106 0.326547092683573 1572 3107280
SGTC_719 2810-4230 27.3 µM 0.449361037864905 0.328919122586755 no 1107 0.326585616471598 1580 721079
SGTC_1281 0884-0031 11.8 µM 0.447483065142533 0.32960629172297 no 1108 0.32726315628493 1529 1548255
SGTC_186 3455-3465 67.277 µM 0.447249522728624 0.329691787538908 no 1109 0.327347454177815 1547 755278
SGTC_2203 7227154 166.4 µM 0.446289758292499 0.330043234013356 no 1110 0.327693976679188 1552 896304
SGTC_929 2805-0021 398 µM 0.446167673145842 0.330087949906991 no 1111 0.327738066113 1607 3098024
SGTC_2541 muurolladie-3-one 83.07 µM 0.445710000144414 0.330255602525815 no 1112 0.327903370029069 1584 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1626 st003712 1.76 µM 0.444229357107562 0.330798218065508 no 1113 0.328438384686102 1600 24207035
SGTC_1866 st057638 64 µM 0.443594391725347 0.331031024718791 no 1114 0.328667930597324 1567 688802
SGTC_433 pimozide 108 µM 0.442672103034167 0.331369293295683 no 1115 0.329001461722369 1483 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1438 4092-1045 4 µM 0.442517234852201 0.331426107927437 no 1116 0.329057480713561 1529 1351342
SGTC_2666 tannic acid 100 µM 0.440994501386176 0.331984941310551 no 1117 0.329608488861843 1595 16134267 A thiamine antagonist.
SGTC_2281 7943571 200 µM 0.440874469121281 0.332029008295451 no 1118 0.329651938843821 1667 1244024
SGTC_1735 st034310 56.75 µM 0.440675809907012 0.332101946394951 no 1119 0.329723855721059 1654 871153
SGTC_249 wiskostatin 11.211 µM 0.439781557832666 0.332430351440901 no 1120 0.330047662990264 1635 2775510 A n-wasp and actin depolymerizer.
SGTC_3186 9110464 49.47 µM 0.439628408478627 0.33248660690761 no 1121 0.330103130910803 1604 17018021
SGTC_1846 st056244 14.8 µM 0.439519903113502 0.332526465839756 no 1122 0.33014243184805 1609 5393182
SGTC_3110 9122132 49.47 µM 0.439494477068433 0.332535806250903 no 1123 0.330151641501544 1638 918317
SGTC_2658 polymyxin b sulfate 77.05 µM 0.438735284454778 0.332814748120749 no 1124 0.330426678609418 1552 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_227 fluconazole 33.516 µM 0.438277480794775 0.332982998679068 no 1125 0.330592574087211 1525 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2794 7785382 27.27 µM 0.437266315354875 0.333354738145363 no 1126 0.33095911060678 1633 2205081
SGTC_3188 9110789 49.47 µM 0.436997106358658 0.333453736318448 no 1127 0.331056723287812 1636 849217
SGTC_3196 9111891 49.47 µM 0.436095066993835 0.333785534307888 no 1128 0.331383878056373 1546 18891510
SGTC_3054 9094397 49.47 µM 0.435035564238139 0.334175418233666 no 1129 0.331768306563904 1501 2598354
SGTC_2482 5981709 142.65 µM 0.434802761248787 0.334261110858741 no 1130 0.331852800239161 1605 877755
SGTC_597 k018-0003 82.8 µM 0.43360882442206 0.334700723627807 no 1131 0.332286262817036 1665 6786234
SGTC_1248 0469-0687 58.6 µM 0.432635301926199 0.335059346679539 no 1132 0.332639869420904 1653 4017482
SGTC_1501 4491-0275 38.4 µM 0.431695216330657 0.335405795130585 no 1133 0.332981472324359 1644 5104718
SGTC_822 1487-0950 154 µM 0.430618442570041 0.33580278910823 no 1134 0.333372914542014 1625 1958375
SGTC_1892 st058411 7.36 µM 0.42914625051917 0.336345865790643 no 1135 0.333908397860097 1655 3934738
SGTC_636 0kpi-0074 126 µM 0.428710094122008 0.336506825105407 no 1136 0.334067106911398 1576 616434
SGTC_62 0180-0423 3.232 µM 0.42755911056706 0.336931728297266 no 1137 0.334486070461629 1565 30102 YGL099W LSG1
SGTC_1672 st016598 6.51 µM 0.427284995769163 0.337032952683152 no 1138 0.334585879989414 1540 4665860 YNL267W PIK1
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.425999739080463 0.33750772616199 no 1139 0.335054018067373 1606 5379071
SGTC_2449 5812982 45.77 µM 0.425403296530417 0.337728139839824 no 1140 0.33527135166486 1580 776185
SGTC_2806 7952793 58.44 µM 0.424122710188386 0.338201564931484 no 1141 0.335738161952129 1628 2972490
SGTC_2441 5730946 39.09 µM 0.423974107191991 0.338256519155632 no 1142 0.335792348421563 1680 1774275
SGTC_734 2023-0417 80 µM 0.422231383581322 0.338901245036856 no 1143 0.336428068194865 1641 3935732
SGTC_1574 spiramycin 23.7 µM 0.421735708003746 0.339084708053519 no 1144 0.336608968854206 1527 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2688 kanamycin b 96.69 µM 0.420929863696782 0.339383054400294 no 1145 0.336903148712335 1585 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1346 1488-2224 62.4 µM 0.420506482274224 0.339539842540035 no 1146 0.337057747462381 1664 3722427
SGTC_2 0422-0095 29 µM 0.420500145776721 0.339542189305731 no 1147 0.337060061458889 1560 6790840
SGTC_318 1488-0629 67.2 µM 0.42024040175393 0.339638392655568 no 1148 0.337154921494824 1556 3662576
SGTC_1837 st055472 66.5 µM 0.41751007760297 0.340650274487091 no 1149 0.338152677332968 1657 676091
SGTC_704 1310-0270 142 µM 0.417343259487121 0.34071213601051 no 1150 0.338213675453104 1556 5718033
SGTC_332 4112-0506 40.9 µM 0.417144331852739 0.340785910376938 no 1151 0.338286420177403 1628 2790355
SGTC_2011 4012611 177 µM 0.416958258478586 0.340854923120772 no 1152 0.33835446976405 1557 2049887
SGTC_126 0417-1624 672.48 µM 0.414859324605785 0.341633765018516 no 1153 0.339122443910207 1677 41912 YDL195W SEC31
SGTC_971 1315-0384 26.7 µM 0.414266907195067 0.341853712904627 no 1154 0.339339323353491 1567 6769120
SGTC_3181 9108277 49.47 µM 0.414121925905308 0.341907548551271 no 1155 0.339392407995391 1555 17097298
SGTC_1588 farnesol 29.9 µM 0.413777766951065 0.342035357360208 no 1156 0.339518433947135 1578 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1795 st049545 62.3 µM 0.413590157183594 0.342105036805279 no 1157 0.339587141446612 1715 5291882
SGTC_1398 3558-0053 112 µM 0.413125288050715 0.342277715283511 no 1158 0.339757411391238 1584 4532369
SGTC_2627 acetyl isogambogic acid 100 µM 0.412365590688234 0.342559980486952 no 1159 0.340035739925732 1533 6857789 A caspase activator and apoptosis inducer.
SGTC_2453 5731132 22.18 µM 0.406933526013459 0.344580815908847 no 1160 0.342028405764571 1750 1362040
SGTC_651 3253-0966 34.4 µM 0.406759980156444 0.344645451949501 no 1161 0.34209214123196 1591 781462
SGTC_2813 7971799 71.43 µM 0.406448578785781 0.344761442761405 no 1162 0.342206516012451 1641 2234054
SGTC_3252 9135871 49.47 µM 0.405403837975177 0.345150694474872 no 1163 0.342590345146823 1658 17682838
SGTC_1149 3909-7961 23.3 µM 0.404639002880623 0.345435762266934 no 1164 0.34287144234734 1569 735261
SGTC_1230 0170-0365 3.77 µM 0.403445636505492 0.345880726485688 no 1165 0.343310209907919 1689 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_190 3970-0790 3.722 µM 0.403194064742622 0.345974555916963 no 1166 0.343402732819066 1691 2832352
SGTC_1151 3909-8316 15.3 µM 0.403172451596475 0.34598261747444 no 1167 0.343410682126776 1612 800431
SGTC_136 0097-0015 404.482 µM 0.40187112661379 0.346468131422844 no 1168 0.343889436537841 1661 4861337
SGTC_2060 5238662 140 µM 0.40167476521477 0.346541414222051 no 1169 0.343961699198766 1609 790130
SGTC_1924 st058459 75.1 µM 0.399861579832371 0.347218372773438 no 1170 0.344629235815314 1617 688683
SGTC_2302 7771753 200 µM 0.399542907761126 0.347337400464755 no 1171 0.344746607196473 1570 2203047
SGTC_2682 pyrogallin 40.03 µM 0.397780583949018 0.347995920326197 no 1172 0.34539596529166 1669 822798 An ATP competetive kinase inhibitor.
SGTC_3096 9117468 49.47 µM 0.395150198490513 0.348979657791232 no 1173 0.346366021966253 1619 41316311
SGTC_1912 st060209 90.8 µM 0.394372806876678 0.349270589148883 no 1174 0.346652908663427 1570 688787
SGTC_718 1130-0073 349 µM 0.394224194378058 0.349326216043421 no 1175 0.346707762276153 1706 6740020
SGTC_2369 9071472 200 µM 0.39381292784781 0.349480173396077 no 1176 0.346859579548793 1684 17296037
SGTC_2119 5528445 120.635 µM 0.392021687450126 0.350151011577763 no 1177 0.34752109475243 1713 791935
SGTC_2665 lovastatin 100 µM 0.391569006081114 0.350320619605461 no 1178 0.347688346167708 1629 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_389 tpck 16.7 µM 0.391069393036306 0.350507846376737 no 1179 0.347872971767294 1638 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2019 4016004 108 µM 0.389924016393449 0.350937205922934 no 1180 0.348296367123127 1598 45595336
SGTC_2809 7964133 12.99 µM 0.38972633548393 0.351011328501779 no 1181 0.348369460210197 1664 1253665
SGTC_339 3091-4833 71.4 µM 0.387108124038982 0.351993588829369 no 1182 0.349338081743523 1682 3240077
SGTC_2032 5185112 25.99 µM 0.3869730833734 0.352044278172506 no 1183 0.349388067455858 1660 5718189
SGTC_2717 st081029 62.2815 µM 0.386573968671974 0.35219410664794 no 1184 0.349535816240246 1732 5292846
SGTC_3009 9080819 71.4286 µM 0.386135982619999 0.352358553913977 no 1185 0.349697981095277 1630 17027216
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.385278541099895 0.352680570805433 no 1186 0.350015529217651 1711 1377
SGTC_1809 st050081 57.6 µM 0.384873162210787 0.352832849857135 no 1187 0.350165695302461 1715 5036894
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.383707772824546 0.353270755243239 no 1188 0.350597525471672 1585 6708514
SGTC_1302 1159-0335 255 µM 0.383535120478136 0.353335647434283 no 1189 0.350661517516295 1626 649284
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.382239869872023 0.353822609297183 no 1190 0.351141725574127 1672 4213774
SGTC_2108 5365811 200 µM 0.382144898489878 0.353858324121201 no 1191 0.351176945132463 1702 780283
SGTC_3231 9132313 49.47 µM 0.381543053623327 0.354084683066955 no 1192 0.351400165339163 1676 4905967
SGTC_2623 humulene 100 µM 0.379137009614638 0.354990131097501 no 1193 0.35229306229056 1615 6187145 An anti-inflammatory.
SGTC_952 1185-0122 232 µM 0.37779756358324 0.355494549989231 no 1194 0.352790491899638 1613 678600
SGTC_1226 3909-7979 35.4 µM 0.377043051188525 0.355778801623813 no 1195 0.35307080581684 1774 6615510
SGTC_152 4469-0003 551.229 µM 0.376195735065351 0.356098111330642 no 1196 0.353385692931801 1708 697280
SGTC_939 1165-0479 45.3 µM 0.37606925120974 0.356145785231183 no 1197 0.353432706597378 1730 1377347
SGTC_98 0074-0023 107.663 µM 0.374875114041469 0.356595986438164 no 1198 0.353876673894437 1597 3563821
SGTC_2297 7971671 152.32 µM 0.374369840370546 0.356786539690364 no 1199 0.354064589069126 1759 909016
SGTC_2981 9013952 38.96 µM 0.373020000795216 0.35729577824425 no 1200 0.354566779044913 1554 2996344
SGTC_3238 9133470 49.47 µM 0.372856519357163 0.357357470297831 no 1201 0.354627617340243 1760 3534688
SGTC_201 4262-0159 12.803 µM 0.372550768950031 0.357472859582898 no 1202 0.354741409834779 1774 1341029
SGTC_1247 0448-0043 5.84 µM 0.372188975861518 0.357609416040013 no 1203 0.3548760767279 1664 3089013 YGL099W LSG1
SGTC_1659 st012954 42.1 µM 0.371162726593244 0.357996866322831 no 1204 0.355258166622667 1700 24207262
SGTC_2742 clothiapine 36.27 µM 0.370047712812722 0.358417994613899 no 1205 0.355673470028169 1766 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_993 3909-8757 62.7 µM 0.369486720095193 0.35862994048552 no 1206 0.355882484915881 1682 4288324 YLR208W SEC13
SGTC_933 2914-0560 114 µM 0.366594434750571 0.359723350156212 no 1207 0.356960780032858 1835 463887
SGTC_1840 st055363 71 µM 0.36550421190041 0.360135800535819 no 1208 0.357367531671359 1608 676033
SGTC_406 estrone 100 µM 0.364134511059917 0.360654213129568 no 1209 0.35787878358282 1799 5870 A steroid.
SGTC_556 4058-0063 51.5 µM 0.363677326027841 0.360827308339749 no 1210 0.35804948840752 1692 6615692
SGTC_1684 st024538 14.6195 µM 0.363128151721933 0.361035269379288 no 1211 0.35825457792794 1658 6732859
SGTC_1045 1348-1485 165 µM 0.361142548046936 0.361787519157711 no 1212 0.358996443890588 1670 6810614
SGTC_1839 st053978 48 µM 0.360265740428898 0.362119869678399 no 1213 0.359324208371251 1715 3788398
SGTC_1278 0874-0585 172 µM 0.358820690925648 0.362667836878977 no 1214 0.359864616467176 1733 766306
SGTC_1640 st009078 66.4 µM 0.358502537109809 0.362788519617076 no 1215 0.35998363477754 1765 690618
SGTC_3226 9131256 49.47 µM 0.35754229960726 0.363152841422397 no 1216 0.360342932753073 1673 17178073
SGTC_137 0438-0332 85.389 µM 0.356110631355927 0.363696257745738 no 1217 0.360878857890133 1690 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1223 0764-0573 147 µM 0.356091207406475 0.363703632355694 no 1218 0.3608861308573 1683 1609797
SGTC_1725 st036284 20.55 µM 0.354553984286179 0.364287423377286 no 1219 0.361461877211438 1842 707914
SGTC_661 1304-0007 33.6 µM 0.35368927015946 0.364615954271351 no 1220 0.361785882338223 1669 3117130
SGTC_3093 9117344 49.47 µM 0.352218765186502 0.365174871589561 no 1221 0.362337102478738 1716 24824913
SGTC_2718 lomofungin 53.02 µM 0.352084549118809 0.365225899430209 no 1222 0.362387427732709 1805 5351222 A RNA synthesis inhibitor.
SGTC_593 1203-0218 61.7 µM 0.351826675364544 0.365323947598369 no 1223 0.362484125975302 1796 3666956
SGTC_2685 mycophenolic acid 18.85 µM 0.351809659318662 0.365330417710026 no 1224 0.36249050700979 1761 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2655 perillic acid 100 µM 0.350234349110276 0.365929573017752 no 1225 0.36308141519005 1686 5702197 An apoptosis inducer.
SGTC_2194 5927483 104.545 µM 0.349882008706675 0.366063627391968 no 1226 0.363213624832344 1738 760979
SGTC_193 1273-0060 1.558 µM 0.349198175664652 0.36632385087562 no 1227 0.363470267856662 1765 2847393 YHR072W ERG7
SGTC_614 0462-0418 107 µM 0.348676705282364 0.36652233075335 no 1228 0.36366601725626 1651 5188303
SGTC_114 0364-0001 490.298 µM 0.34592329289214 0.367570913879183 no 1229 0.364700181447659 1648 4003655
SGTC_2707 st078556 66.6 µM 0.345331449702665 0.367796435037213 no 1230 0.364922602903361 1837 17250899
SGTC_1475 4092-1048 11.7 µM 0.345077547161256 0.36789319828253 no 1231 0.365018036328909 1691 2881759
SGTC_2340 7987427 183.45 µM 0.343725493091486 0.36840861240511 no 1232 0.365526368667939 1754 2239331
SGTC_1978 st071761 42 µM 0.343425522129678 0.368522995940698 no 1233 0.365639180933994 1668 5147680
SGTC_1710 st031758 61.5 µM 0.342852615842835 0.368741486276893 no 1234 0.365854670264837 1797 5394341
SGTC_1653 st012112 65 µM 0.342213994534082 0.36898508848572 no 1235 0.366094927116626 1781 720429
SGTC_882 0843-0131 351 µM 0.342164390073991 0.36900401231988 no 1236 0.366113591097238 1770 5425421
SGTC_2667 digitoxin 100 µM 0.337498524521063 0.370785428662253 no 1237 0.367870562114967 1826 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1848 st056003 16.4 µM 0.336082188012645 0.371326733049169 no 1238 0.368404444954819 1855 146492
SGTC_573 3702-0553 84.7 µM 0.335396832061354 0.371588758173435 no 1239 0.368662878680401 1725 1222756
SGTC_473 2-arachidonoylglycerol 10 µM 0.334897973080955 0.371779519249683 no 1240 0.368851025576183 1684 5282280 An endocannabinoid.
SGTC_751 0833-0568 350 µM 0.334737445444878 0.371840910879974 no 1241 0.368911575979554 1751 6954252
SGTC_3105 9121040 49.47 µM 0.334374416092626 0.371979758577804 no 1242 0.369048521244178 1804 41448907
SGTC_393 acivicin 6.25 µM 0.334121993220495 0.372076312472001 no 1243 0.369143752316495 1728 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1831 st055328 12 µM 0.333887773755937 0.372165910603269 no 1244 0.369232123009909 1830 1103068
SGTC_3122 9126309 49.47 µM 0.333575407585102 0.372285413684498 no 1245 0.369349989105856 1858 17591206
SGTC_1173 0443-0020 122 µM 0.332987925457537 0.372510202206574 no 1246 0.36957169882255 1706 5331295
SGTC_3259 9138485 49.47 µM 0.332921667077385 0.372535557404187 no 1247 0.369596706777398 1832 17646153
SGTC_260 nsc-65238 3.989 µM 0.33085057990901 0.373328381543707 no 1248 0.370378676528839 1794 3246252
SGTC_58 0957-0393 9 µM 0.330732618798488 0.373373553920577 no 1249 0.370423230661915 1710 6997992
SGTC_2440 5628896 157.78 µM 0.330387038516086 0.373505901471832 no 1250 0.370553766987404 1742 5522048
SGTC_1788 fluconazole 20 µM 0.330023402777453 0.373645179866985 no 1251 0.370691139508334 1695 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2921 7974240 10.71 µM 0.329350791941 0.373902844228588 no 1252 0.370945278561182 1771 2979074 YDR527W RBA50
SGTC_3341 9147222 25.867 µM 0.327780257820139 0.374504705101576 no 1253 0.371538907693439 1756 1939759
SGTC_3195 9113082 49.47 µM 0.327472594698167 0.374622643794546 no 1254 0.371655233781374 1877 17018038
SGTC_2605 digitonin 300 nM 0.326580400991604 0.374964721044907 no 1255 0.371992634581265 1880 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.324357100898572 0.375817587216234 no 1256 0.37283384701797 1761 688788
SGTC_2601 securinine 100 µM 0.323474648998192 0.376156267562244 no 1257 0.373167901792201 1689 442872 A GABA receptor antagonist.
SGTC_2999 9069765 71.4286 µM 0.322766183963198 0.376428241725938 no 1258 0.373436162353933 1799 2097066
SGTC_1754 st042065 16.137 µM 0.322278414961196 0.376615528090824 no 1259 0.373620891943602 1779 1126236 YIL048W NEO1
SGTC_382 3229-0966 23.2 µM 0.32217927986461 0.376653596079588 no 1260 0.373658440287873 1831 5722370
SGTC_3039 9090270 49.47 µM 0.321788421327638 0.376803697882134 no 1261 0.373806493293765 1885 17173750
SGTC_1967 st070177 51.4 µM 0.321654730058002 0.376855043752487 no 1262 0.37385713838263 1805 5729214
SGTC_613 3914-0030 117 µM 0.321351828389661 0.376971385133126 no 1263 0.373971892015795 1766 1145395
SGTC_435 c-PAF 6.7 µM 0.320558759096377 0.377276047689806 no 1264 0.374272397466322 1864 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_647 0140-0236 81 µM 0.319532956681751 0.377670229437627 no 1265 0.374661202173991 1786 990837
SGTC_880 0833-0487 87.2 µM 0.318911094928346 0.377909252296247 no 1266 0.374896965373191 1707 76075
SGTC_3017 9080681 49.47 µM 0.31663003343708 0.378786415642256 no 1267 0.375762172028359 1730 16451914
SGTC_167 3672-0051 66.205 µM 0.315351291776994 0.379278418756392 no 1268 0.376247472462676 1697 3237971
SGTC_860 0443-0016 25.1 µM 0.315018124023551 0.379406639092644 no 1269 0.376373946479923 1776 5337942
SGTC_215 1287-0124 461.5 µM 0.314423543941045 0.379635497485933 no 1270 0.376599688369381 1884 5560863
SGTC_287 k060-0039 29.6 µM 0.313302815809217 0.380066988867241 no 1271 0.377025305523324 1866 5861974
SGTC_3215 9129942 49.47 µM 0.312644209377899 0.380320628534041 no 1272 0.377275493208207 1911 17682944
SGTC_1709 st033179 39.1045 µM 0.311862724324469 0.380621657446904 no 1273 0.377572426157761 1748 573381
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.306805428361113 0.38257147372143 no 1274 0.379495738087806 1865 94937 An inhibitor of serotonin biosynthesis.
SGTC_1369 1866-0067 208 µM 0.306070440403331 0.382855094040097 no 1275 0.379775506862599 1859 3531355
SGTC_1269 0831-0796 3.05 µM 0.306029501621475 0.382870893522069 no 1276 0.379791091817193 1861 927758
SGTC_615 k087-0205 167 µM 0.304827020438728 0.38333505326679 no 1277 0.380248950486532 1710 9642773
SGTC_599 1935-0052 86.5 µM 0.302259644476946 0.384326624537405 no 1278 0.381227069711828 1775 9557311
SGTC_3255 9139072 49.47 µM 0.301794717517065 0.384506269697213 no 1279 0.381404279020235 1790 17646060
SGTC_579 4491-1009 110 µM 0.301529058276753 0.38460893007114 no 1280 0.381505547575685 1952 1271041
SGTC_108 0509-0257 621.132 µM 0.299817495471582 0.385270533795112 no 1281 0.382158184719585 1859 536624
SGTC_639 0833-0042 114 µM 0.29915375577937 0.385527192033549 no 1282 0.382411365979085 1729 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_3026 9090633 49.47 µM 0.298201579761858 0.385895471822647 no 1283 0.38277465806962 1743 25236842
SGTC_1391 3442-0225 151 µM 0.294415025582604 0.387361038777231 no 1284 0.38422039334713 1800 5227075
SGTC_2235 salicylic acid 500 µM 0.294288632550175 0.387409986398427 no 1285 0.384268679089283 1836 338 A COX inhibitor and kinase inhibitor.
SGTC_3349 9149703 23.001 µM 0.29347226317585 0.387726180919293 no 1286 0.38458059870097 1773 4910494
SGTC_2732 terfenadine 20 µM 0.293285819850712 0.387798404221049 no 1287 0.384651845731444 1827 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_85 0868-0259 160.055 µM 0.293260364558243 0.387808265241452 no 1288 0.384661573461643 1809 83173
SGTC_424 splitomicin 100 mM 0.293210641797234 0.387827527344764 no 1289 0.384680575205042 1714 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_789 1309-1135 70.6 µM 0.292826905837687 0.387976192122781 no 1290 0.384827230686275 1703 3092424
SGTC_3210 9128157 49.47 µM 0.292627105898669 0.388053603967532 no 1291 0.384903596373584 1686 17590849
SGTC_2586 curcumin 80 µM 0.292155484834845 0.388236349672395 no 1292 0.385083872724385 1868 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2885 9057732 51.95 µM 0.288223661450427 0.38976082861049 no 1293 0.386587768863203 1801 6471414
SGTC_1018 4259-0013 28.1 µM 0.287915597373949 0.389880345765975 no 1294 0.386705673626669 1819 6801262
SGTC_571 k831-0106 44.2 µM 0.287835353816695 0.389911478926765 no 1295 0.386736386804174 1927 4783639
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.287607706164165 0.38999980625944 no 1296 0.386823522678601 1868 6708630 An antioxidant.
SGTC_3312 9133330 71.43 µM 0.287366193079376 0.390093519591891 no 1297 0.386915972011723 1879 17617324
SGTC_2643 anethole 100 µM 0.287304143264876 0.390117597558723 no 1298 0.386939725235027 1814 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1820 st053765 18.6 µM 0.285939900700942 0.390647088062104 no 1299 0.387462076330908 1751 3690829
SGTC_2294 7971431 200 µM 0.284177387146977 0.391331455893583 no 1300 0.388137221921574 1858 5741572
SGTC_2415 st077333 57.7 µM 0.283997964626126 0.391401142920335 no 1301 0.388205970223555 2006 2766255
SGTC_2988 9073640 71.4286 µM 0.28365347027956 0.391534952988046 no 1302 0.388337977972248 1841 9102229
SGTC_606 k015-0008 38.6 µM 0.282969419186655 0.391800693271089 no 1303 0.388600139641996 1918 1970475
SGTC_1474 0330-0125 5.35 µM 0.281038855309889 0.392550950993741 no 1304 0.389340299036138 1807 X1474
SGTC_2274 7947094 46.08 µM 0.280975860859391 0.3925754387072 no 1305 0.389364457276415 1788 2971028
SGTC_1596 piperlongumine 63 µM 0.279670887283794 0.39308281413614 no 1306 0.389865007967921 1941 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_800 3448-7362 155 µM 0.279073482760176 0.393315146469543 no 1307 0.390094216342421 1838 15991913
SGTC_2104 5389443 200 µM 0.276680140128403 0.394246304543829 no 1308 0.391012861329203 1890 2244536
SGTC_997 3996-0078 137 µM 0.276256548402991 0.394411171021041 no 1309 0.391175513527246 1823 735687
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 0.275378260806508 0.394753070288527 no 1310 0.391512822018316 1879 616764
SGTC_2381 9035592 200 µM 0.274966241434234 0.394913488895891 no 1311 0.391671087192633 1750 4749657
SGTC_1425 4048-4433 7.33 µM 0.274437382134476 0.395119424915336 no 1312 0.391874259278956 1915 23734946
SGTC_2639 lactacystin 53 µM 0.273383680539115 0.395529820036017 no 1313 0.392279148097408 1909 3870 A proteasome inhibitor.
SGTC_1888 azatryptophan 97.5 µM 0.272761085484835 0.395772362506226 no 1314 0.392518437450727 1813 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1035 k081-0041 55.2 µM 0.270718976412577 0.396568183611612 no 1315 0.393303590287518 1947 731709
SGTC_343 4130-2827 29.8 µM 0.269551192145548 0.397023469503395 no 1316 0.393752776880365 1776 1118244
SGTC_2826 7992541 19.48 µM 0.268493974070835 0.397435769875014 no 1317 0.394159556322705 1890 2985066
SGTC_2465 5809242 33.21 µM 0.267790443014703 0.397710200764473 no 1318 0.394430313757746 1883 2731748
SGTC_2761 levamisole 97.89 µM 0.267658394073072 0.397761715592592 no 1319 0.394481139141388 1944 26879 An alkaline phosphatase inhibitor.
SGTC_2851 9015922 71.43 µM 0.266063434253389 0.398384080611179 no 1320 0.395095177757017 1912 2996893
SGTC_541 4513-1321 94 µM 0.265250504823461 0.398701391215679 no 1321 0.39540824529144 1791 747515
SGTC_1389 3405-0187 19 µM 0.265121979988368 0.398751564428911 no 1322 0.395457747720953 1785 799890
SGTC_1513 0337-0559 19 µM 0.263237514324144 0.399487409276313 no 1323 0.396183758928569 1766 775073
SGTC_1654 st012436 41.8 µM 0.263001175237177 0.39957972006068 no 1324 0.396274836643548 1941 4323132
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.262471724444191 0.399786536597825 no 1325 0.396478891010808 1944 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2241 6772625 37.8075 µM 0.261428284625991 0.400194212184045 no 1326 0.396881123629182 1910 2285411
SGTC_1768 st044301 37.178 µM 0.26115320072642 0.400301706563087 no 1327 0.396987183226847 1814 3931349
SGTC_282 k297-0036 65.7 µM 0.260606397216563 0.400515403080751 no 1328 0.397198027926982 1896 5061378
SGTC_270 tamoxifen 5.46 µM 0.260495896297912 0.400558591612265 no 1329 0.397240640180398 1970 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.2599097339619 0.400787709486805 no 1330 0.397466701316422 1799 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_681 1642-0006 26.6 µM 0.259601130179286 0.400908349591481 no 1331 0.397585732227703 1891 4446530
SGTC_2335 9018011 154.17 µM 0.259014497161968 0.401137703575887 no 1332 0.397812027491416 1956 6458208
SGTC_97 0535-0701 19.132 µM 0.258873522088852 0.401192825218228 no 1333 0.397866414132441 1793 2832013 YGL099W LSG1
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.258766913994873 0.401234510583002 no 1334 0.397907543686957 1880 2724278 An inhibitor of dopamine biosynthesis.
SGTC_862 0452-0056 10.2 µM 0.257557457252006 0.401707504938252 no 1335 0.398374233169918 1931 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2484 5809818 12.04 µM 0.257404790638604 0.401767220050751 no 1336 0.398433152531008 1831 2870548
SGTC_2914 7968218 45.32 µM 0.257398217264578 0.401769791258858 no 1337 0.398435689476895 1937 2977111
SGTC_1301 naphtanilide LB 4.81 µM 0.257110525373939 0.401882327543798 no 1338 0.398546726272808 1944 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_987 1497-1013 404 µM 0.256087807060481 0.402282449533497 no 1339 0.398941518348104 1893 1676435
SGTC_888 0916-0002 6.97 µM 0.255411865186189 0.402546957090453 no 1340 0.399202503769028 1919 2802138 YIL048W NEO1
SGTC_448 monastrol 171 µM 0.255243456330212 0.402612865289348 no 1341 0.399267534506863 1920 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_690 glyoxal 20.3 µM 0.254947352904394 0.402728754525282 no 1342 0.399381881020959 1874 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1692 fluoroquinolonic acid 71 µM 0.254181672544553 0.403028466824497 no 1343 0.399677604461841 1908 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_205 1486-1330 71.903 µM 0.252213137791924 0.403799276789089 no 1344 0.400438161886011 1874 4118834
SGTC_2326 6164455 177.58 µM 0.252044565950199 0.403865301093527 no 1345 0.400503308413768 1835 2888790
SGTC_1157 4092-0394 27.6 µM 0.250405358781924 0.404507469688103 no 1346 0.401136942946221 1941 3659885
SGTC_2828 7998861 71.43 µM 0.249719958025077 0.404776055669655 no 1347 0.401401961409302 1992 2988188
SGTC_355 1311-2252 105 µM 0.249421357125771 0.404893081566672 no 1348 0.401517433239243 1825 5338538
SGTC_1856 st057054 55.7 µM 0.247809449794953 0.405524957392475 no 1349 0.40214092153315 1992 1266018
SGTC_1238 0333-0287 48.8 µM 0.24604746332153 0.406215946709319 no 1350 0.402822745590156 1861 7226
SGTC_1793 st048256 72.231 µM 0.245347507543747 0.406490526042076 no 1351 0.403093684935766 1920 672022
SGTC_2958 9077254 16.72 µM 0.244798289714414 0.406706005950558 no 1352 0.403306309123327 1866 16457351
SGTC_3351 9150312 21.596 µM 0.244533951793635 0.406809726261323 no 1353 0.403408655099437 1963 4904905
SGTC_974 1326-0144 138 µM 0.243841799638347 0.407081342296511 no 1354 0.403676672899843 1837 5411856
SGTC_1468 k284-1086 134 µM 0.243414504602409 0.407249044776 no 1355 0.403842154307273 1867 15996457
SGTC_2545 solidagenone 89.61 µM 0.242672647755678 0.407540245169897 no 1356 0.404129499039025 1897 6708572 An anti ulcer agent
SGTC_2074 5212007 75.395 µM 0.2425622745058 0.407583574251952 no 1357 0.40417225453093 2025 758611
SGTC_2128 5255449 168.493 µM 0.242321913393678 0.407677936409974 no 1358 0.404265367623772 1856 736008
SGTC_2382 9035899 200 µM 0.242045371171814 0.407786509353884 no 1359 0.404372503565974 1843 6462679
SGTC_1108 betulinic acid 729.144 nM 0.241855478993991 0.40786106681916 no 1360 0.404446074342382 1853 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3046 9092212 49.47 µM 0.24126709415743 0.408092105842147 no 1361 0.404674056357183 1880 25236637
SGTC_1160 4092-0570 10.5 µM 0.240327325728061 0.408461187690947 no 1362 0.405038256397193 1808 4994975
SGTC_3081 9117243 49.47 µM 0.238666741367922 0.40911355898167 no 1363 0.405682004038212 1987 45595589
SGTC_3065 9113888 49.47 µM 0.238014725467369 0.409369776588695 no 1364 0.405934836546386 1950 16648368
SGTC_2384 9036245 200 µM 0.237439592349777 0.409595814311268 no 1365 0.406157888757722 1979 6462766
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.23639749000815 0.410005455902156 no 1366 0.406562121845094 1870 5355888
SGTC_1200 1643-0193 18.4 µM 0.235944968818093 0.410183368760568 no 1367 0.406737686543146 1997 5403974
SGTC_956 1185-0240 191 µM 0.235235608871772 0.41046229732713 no 1368 0.407012934715132 1892 1416193
SGTC_96 0929-0093 37.281 µM 0.233684184852328 0.41107249294245 no 1369 0.407615083256162 1856 6991579
SGTC_653 0203-0016 55.2 µM 0.232287564960065 0.411621986181452 no 1370 0.408157335026576 1931 295302
SGTC_19 0279-0214 38.434 µM 0.232209623325339 0.41165265705277 no 1371 0.408187601845749 1915 3566274 YBR002C RER2
SGTC_717 1532-0246 73.2 µM 0.230606127037674 0.412283769615664 no 1372 0.408810403606454 1884 9561992
SGTC_549 1661-1316 519 µM 0.230171711597673 0.412454788275156 no 1373 0.408979171311586 2003 2857282
SGTC_83 0170-0301 39.027 µM 0.229916360035308 0.412555321655344 no 1374 0.409078381687687 1994 3089716
SGTC_1245 0418-0076 17.2 µM 0.229672978416682 0.412651147739773 no 1375 0.409172946867286 1916 6790114
SGTC_80 0159-0065 512.242 µM 0.228962983610269 0.412930722086894 no 1376 0.40944884335029 2013 1548079
SGTC_2939 9044578 71.43 µM 0.228689673862244 0.413038354929123 no 1377 0.409555060595473 1869 2653634
SGTC_885 0865-0106 16.8 µM 0.226213404968759 0.414013837971697 no 1378 0.410517722583247 1835 2793380
SGTC_3202 9113761 49.47 µM 0.224567411627539 0.414662542448301 no 1379 0.411157909555199 2021 4798415
SGTC_2962 9082311 13.18 µM 0.224345509508485 0.41475001441446 no 1380 0.411244233540861 1861 16459453
SGTC_3235 9132602 49.47 µM 0.224066191581897 0.414860125222261 no 1381 0.411352899435365 1939 4912240
SGTC_3151 9099821 49.47 µM 0.223680269529442 0.415012271785682 no 1382 0.411503049805818 1859 17174189
SGTC_1671 st016596 74.5 µM 0.222962301417363 0.41529535865106 no 1383 0.411782423531498 1913 2829167
SGTC_2049 5262831 67.185 µM 0.222567574240236 0.415451013944831 no 1384 0.411936037719662 1901 763417
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.222522279267168 0.415468876250553 no 1385 0.411953665822858 2011 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1415 3966-0071 78.1 µM 0.2223214527986 0.415548075305694 no 1386 0.412031826519183 1947 2893185
SGTC_2324 6149169 200 µM 0.221437542858061 0.415896699739148 no 1387 0.412375881461375 2008 2888231
SGTC_183 3914-0051 30.55 µM 0.221256049887838 0.415968290892724 no 1388 0.412446534504734 2055 1596232
SGTC_1930 st074634 34.3 µM 0.215891697729373 0.418085545966265 no 1389 0.414536084378521 1815 684253 YOR116C RPO31
SGTC_2115 tiliquinol 12.7705 µM 0.21568726891158 0.41816627932318 no 1390 0.414615762795847 1961 71208 A bioactive hydroxyquinoline.
SGTC_978 1416-0512 87.4 µM 0.215571429029133 0.418212028526273 no 1391 0.414660914244833 1918 6814003
SGTC_559 1550-0661 158 µM 0.214546075589188 0.418617024480306 no 1392 0.41506062011144 1960 5830875
SGTC_371 0195-0006 7.36 µM 0.212375905538419 0.419474486216828 no 1393 0.415906890815964 1881 3928593
SGTC_2043 5101342 149 µM 0.211145033331311 0.419960989723416 no 1394 0.416387050376683 1950 678451
SGTC_340 k038-0059 454 µM 0.211085907942202 0.419984362179548 no 1395 0.416410118160948 1945 23733424
SGTC_2082 5219693 150 µM 0.210498762836099 0.420216477828134 no 1396 0.416639208572868 1936 2834649
SGTC_1338 1486-1223 76 µM 0.210229343340761 0.420322996535012 no 1397 0.41674433929764 2002 3444526
SGTC_1413 3910-0535 34.4 µM 0.20919744678046 0.420731024959138 no 1398 0.417147052752571 2021 2876951
SGTC_2821 7996764 71.43 µM 0.208971065356254 0.420820551207462 no 1399 0.417235413218012 1943 2987135
SGTC_3064 1327-0027 10 µM 0.208812285286257 0.420883345834805 no 1400 0.417297390235888 1960 16000455 YPR107C YTH1
SGTC_2710 st078562 53.7235 µM 0.208069201251211 0.42117724877303 no 1401 0.417587467354459 1985 17250908
SGTC_1180 1193-0155 285 µM 0.207592689409221 0.421365740799811 no 1402 0.417773506513054 1921 2921347
SGTC_1965 Pectolinarigenin 58.4 µM 0.207502496982499 0.421401419914137 no 1403 0.417808721400335 1918 5320438 An anti-inflammatory.
SGTC_1079 idarubicin 2.36 µM 0.206959945395175 0.421616060856113 no 1404 0.41802057007865 2055 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1847 st056231 15 µM 0.205488107729415 0.42219845739335 no 1405 0.418595394257198 1963 5393180
SGTC_192 3455-0609 60.9 µM 0.204019303291923 0.422779823345596 no 1406 0.419169207155332 1969 3769639
SGTC_6 0844-0013 19.835 µM 0.203587972353599 0.42295058000547 no 1407 0.419337746484785 2041 1584900
SGTC_2762 leflunomide 42.06 µM 0.203549490682305 0.422965814955404 no 1408 0.419352783628835 1912 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_329 k048-0121 21.3 µM 0.198874369336281 0.424817552892056 no 1409 0.421180509665654 1950 6832902
SGTC_2519 cryptotanshinone 88.04 µM 0.198243549889278 0.425067538026446 no 1410 0.421427257846141 2028 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_633 0437-0093 97.7 µM 0.198134486117777 0.425110761568182 no 1411 0.421469921817146 1957 2831118
SGTC_3214 9129694 49.47 µM 0.197577263571857 0.425331610918656 no 1412 0.421687912578925 2060 17158655
SGTC_2091 4-phenylthiadiazole 200 µM 0.196738312671964 0.425664164543206 no 1413 0.422016163403259 1944 270010
SGTC_589 1227-0070 34.1 µM 0.196343048574766 0.425820862505095 no 1414 0.422170834589258 1984 2841384
SGTC_2689 tacrolimus 100 µM 0.196266617108383 0.425851164244249 no 1415 0.422200744447941 1915 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_714 4296-0578 26.1 µM 0.195959584681036 0.425972893606183 no 1416 0.422320899698035 2076 1589775
SGTC_2461 5755302 26.15 µM 0.195602863024159 0.426114332150447 no 1417 0.422460509600581 2070 2788904
SGTC_1507 4075-3230 155 µM 0.192198232207924 0.427464728787386 no 1418 0.423793465291471 2096 659771
SGTC_1514 1189-1591 158 µM 0.19190287996975 0.427581916205737 no 1419 0.423909140741704 2048 767698 YMR146C TIF34
SGTC_2404 5161160 200 µM 0.191294284515336 0.427823409812715 no 1420 0.424147519352675 1965 2831543
SGTC_2251 lansoprazole 556 µM 0.191082295743485 0.427907534332538 no 1421 0.424230559010114 1874 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2920 7982904 15.77 µM 0.190972421577027 0.427951137514007 no 1422 0.424273599939542 1944 6456808
SGTC_1749 st037932 54.2 µM 0.190963966175087 0.427954493047375 no 1423 0.424276912205588 1939 594497
SGTC_2745 rifampicin 24.3 µM 0.190309181001816 0.428214360899695 no 1424 0.424533429862494 2098 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1630 st005209 31.3 µM 0.189969793055975 0.428349067741922 no 1425 0.424666400560206 2119 3367314
SGTC_2095 5432005 200 µM 0.189923415119587 0.42836747630834 no 1426 0.424684571896938 1970 783734
SGTC_263 alizarin 107.927 µM 0.189789467738027 0.428420644259419 no 1427 0.424737054711787 1996 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2491 paeonol 100 µM 0.188931934881138 0.42876105690919 no 1428 0.425073081940674 1939 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3057 9095946 49.47 µM 0.18864004984144 0.428876937878719 no 1429 0.425187470539457 2039 24540043
SGTC_1610 st001799 48.1 µM 0.187966162696279 0.429144500499607 no 1430 0.425451588302313 1891 621897
SGTC_2141 5621638 7.665 µM 0.187703327616867 0.429248866335237 no 1431 0.425554610788745 2071 2856238
SGTC_2144 5628481 200 µM 0.187503064899241 0.429328389428589 no 1432 0.425633110431841 1961 2818399
SGTC_1979 st071809 45.3 µM 0.187148028786909 0.429469379132713 no 1433 0.425772285905954 2044 4976333
SGTC_1434 4073-0095 163 µM 0.186898634767482 0.429568422295208 no 1434 0.425870054818032 2058 24133745
SGTC_1591 genipin 88.4 µM 0.186866586140764 0.429581150256983 no 1435 0.425882619039969 2064 442424 A DNA cross-linking agent.
SGTC_2027 5150920 200 µM 0.186748549078495 0.429628028753763 no 1436 0.425928894490518 2041 786715
SGTC_1803 st050068 52.4 µM 0.184130777408227 0.43066793234387 no 1437 0.426955431186096 2051 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_338 4055-0136 114 µM 0.183548523536878 0.430899296951704 no 1438 0.42718382456819 1940 2900563
SGTC_3350 9150499 3.57 µM 0.182883479092376 0.431163588262922 no 1439 0.427444723023023 2040 4910996 YPR165W RHO1
SGTC_733 4069-0007 56.1 µM 0.182299992339032 0.431395493613988 no 1440 0.427673652348033 2028 5717425 YNL287W SEC21
SGTC_502 l-744,832 89.3 µM 0.181611039025357 0.431669346828913 no 1441 0.427943992517252 2089 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_3197 9113331 49.47 µM 0.18033849200376 0.432175259954934 no 1442 0.428443419381045 2061 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_3325 9138760 55.175 µM 0.179337493693826 0.432573294524858 no 1443 0.428836354169532 1945 43844959
SGTC_144 4161-2749 112.381 µM 0.177451448471896 0.433323442655715 no 1444 0.429576899220354 2024 797501 YMR168C CEP3
SGTC_2364 9055074 200 µM 0.177368798590735 0.433356321006132 no 1445 0.429609356919504 1944 6470630
SGTC_1443 4112-3303 14 µM 0.17487864719824 0.434347125362401 no 1446 0.430587494388368 1997 704433
SGTC_2875 9039966 71.43 µM 0.173973972248624 0.434707188250771 no 1447 0.430942958706211 2071 6463691
SGTC_1986 st071812 45 µM 0.172710148071927 0.435210284044889 no 1448 0.431439633330226 2095 11838594
SGTC_3269 9137823 49.47 µM 0.171518447403315 0.435684765437335 no 1449 0.431908063220282 1941 17682936
SGTC_3095 9117207 49.47 µM 0.170671655619208 0.436021976002758 no 1450 0.432240975661592 2108 17015229
SGTC_856 0433-0016 11.3 µM 0.1703388270222 0.43615452820239 no 1451 0.432371838936794 1998 3911780
SGTC_1317 1273-0028 910 nM 0.168928647700096 0.436716225104971 no 1452 0.432926382705865 2012 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_2012 4023501 200 µM 0.168771138571067 0.436778971445565 no 1453 0.43298833036006 1977 3477460
SGTC_2117 5521686 200 µM 0.168343119030399 0.436949488067415 no 1454 0.433156676893979 1989 803312
SGTC_844 0330-0132 15.3 µM 0.168315883549232 0.436960338674964 no 1455 0.433167389429868 2096 2828079
SGTC_2635 hydroquinidine 100 µM 0.16831577537305 0.436960381772417 no 1456 0.43316743197892 2001 442912 An experimental heart treatment.
SGTC_3147 9097027 49.47 µM 0.166160977573054 0.437819002223552 no 1457 0.434015133938527 2036 25236841
SGTC_2611 pyromycin 23.93 µM 0.166075889264455 0.437852913326589 no 1458 0.434048614112482 1966 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_92 0063-0024 660.874 µM 0.165927592205077 0.437912016742308 no 1459 0.434106966518786 2144 3594437
SGTC_2696 st077691 74.316 µM 0.164447152002913 0.438502118139502 no 1460 0.434689573426084 2037 757133
SGTC_2887 9044784 58.44 µM 0.164204519378639 0.438598844241731 no 1461 0.434785071725425 2144 6465546
SGTC_1158 4092-0494 91.8 µM 0.163374063066326 0.438929935450382 no 1462 0.435111961586037 2085 1148199
SGTC_1473 k844-0725 134 µM 0.162811919387725 0.439154078468749 no 1463 0.435333261590047 2115 54682906
SGTC_1332 1480-0653 17.5 µM 0.16252300352157 0.439269285214683 no 1464 0.43544700744726 2149 5749438
SGTC_2584 androsterone 48.74 µM 0.162136292541175 0.439423496334333 no 1465 0.435599263490207 2127 2754130 A steroid.
SGTC_3271 9137798 49.47 µM 0.161224177772679 0.439787262331111 no 1466 0.435958419552746 2117 6498326
SGTC_3342 9147791 14.508 µM 0.159877948293135 0.440324253044641 no 1467 0.436488609883645 2083 1838168
SGTC_2121 5257820 149.641 µM 0.159096489008726 0.440636015833214 no 1468 0.436796427177368 2147 791256
SGTC_2942 9052777 62.25 µM 0.159022694019863 0.440665458211569 no 1469 0.436825497049544 2029 6469503
SGTC_3001 9076041 71.4286 µM 0.158754284785838 0.440772549633213 no 1470 0.436931233691877 2054 16004211
SGTC_2224 6650123 117.647 µM 0.157977604806371 0.441082458142304 no 1471 0.43723722293702 2038 2908370
SGTC_2102 5377816 72.7585 µM 0.157692893619176 0.441196071791557 no 1472 0.437349400249743 2131 1379702
SGTC_2308 7584454 197.62 µM 0.157591667871611 0.44123646696835 no 1473 0.437389284801269 2097 893577
SGTC_295 k015-0027 31 µM 0.15649087616292 0.441675788616932 no 1474 0.437823055205699 2065 3887424
SGTC_1955 wogonin 32.4 µM 0.155459205770952 0.442087589374005 no 1475 0.438229655987603 2107 5281703 A flavanone.
SGTC_1617 st002906 78 µM 0.155073931443506 0.44224139125316 no 1476 0.438381516622786 2003 5150859
SGTC_601 0986-0029 62.9 µM 0.154583019988944 0.442437376186118 no 1477 0.438575028579651 2040 24747981
SGTC_3033 9090887 49.47 µM 0.15423007801136 0.442578288736021 no 1478 0.438714163546215 2010 19325384
SGTC_2357 9067248 200 µM 0.152730190205391 0.443177201742859 no 1479 0.439305525863608 2045 9150235
SGTC_2719 novobiocin 32.65 µM 0.152649573732279 0.443209396009307 no 1480 0.439337314452203 2123 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2850 9015429 58.44 µM 0.152407592111879 0.443306033854029 no 1481 0.439432734695957 2042 6457570
SGTC_845 0330-0138 4.51 µM 0.152374291559613 0.443319333035592 no 1482 0.439445866327596 2136 9039800
SGTC_1738 st035555 74 µM 0.151329044775033 0.443736803739129 no 1483 0.439858079346443 2053 5331140
SGTC_1234 0326-0494 15.5 µM 0.15077727088087 0.443957206990072 no 1484 0.440075708237266 2121 1547813
SGTC_707 0865-0008 204 µM 0.14924026729976 0.444571246370732 no 1485 0.440682023525659 2069 723043
SGTC_2946 9065502 71.43 µM 0.14646897481101 0.445678724592809 no 1486 0.441775590134939 2166 16489101
SGTC_2702 st077768 96.8 µM 0.146255203044218 0.445764170895345 no 1487 0.44185996414951 2023 6484119
SGTC_3336 9143619 71.43 µM 0.145909659300166 0.445902292847188 no 1488 0.441996353091222 2145 45595730
SGTC_1555 citronellol 128 µM 0.14277510815458 0.447155544449732 no 1489 0.443233898232561 2165 8842 A terpine precursor.
SGTC_2889 9059656 51.95 µM 0.140022165926143 0.448256657559785 no 1490 0.444321238519971 2095 3949838
SGTC_3024 9090631 49.47 µM 0.139311021968238 0.44854116381892 no 1491 0.444602190270743 2190 25236383
SGTC_2446 5162541 200 µM 0.139028286092796 0.448654284882912 no 1492 0.444713898516816 2048 1549321
SGTC_1162 k048-0130 20.1 µM 0.138452754027213 0.448884564975212 no 1493 0.444941303371944 2029 6797406
SGTC_903 1134-0042 114 µM 0.138148885064723 0.449006155026556 no 1494 0.445061375720858 2021 701009
SGTC_143 4032-1194 15.74 µM 0.137275509461657 0.449355653948991 no 1495 0.445406513886972 2005 1806963
SGTC_1872 amphotericin b 148 nM 0.136730773663285 0.449573660917609 no 1496 0.445621802050833 2141 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1545 lovastatin 49.4 µM 0.132884321295643 0.451113466761425 no 1497 0.447142433361575 2075 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2897 9048598 12.99 µM 0.132249773248218 0.451367559389107 no 1498 0.44739336673226 2089 6467404
SGTC_2852 9023854 51.95 µM 0.132084818981766 0.451433615437363 no 1499 0.447458601699404 2120 19798528
SGTC_3208 9114115 49.47 µM 0.132004783127081 0.451465666334498 no 1500 0.447490254235336 1969 650895
SGTC_460 trequinsin 123 µM 0.13105106736608 0.451847612524886 no 1501 0.447867454900658 2190 5537 A vasodilator.
SGTC_123 0083-0120 66.675 µM 0.130958394500041 0.451884728740306 no 1502 0.447904110128818 1975 16001701
SGTC_3302 9125395 16.351 µM 0.13059658817822 0.452029639055332 no 1503 0.448047220925377 2079 17599668
SGTC_1503 4585-0012 61.3 µM 0.130399635469375 0.452108525049806 no 1504 0.448125127490834 2134 2922052
SGTC_546 peri-Naphthalide 147 µM 0.128475453138131 0.452879321935355 no 1505 0.448886361391057 2135 223824 A penicillin ester.
SGTC_684 1140-0066 328 µM 0.127806871300515 0.453147186923058 no 1506 0.449150906076093 2068 6813534
SGTC_784 4579-0127 173 µM 0.125821123689682 0.453942895027892 no 1507 0.449936760184521 2180 1948547
SGTC_1188 1403-0014 4.57 µM 0.123464181856164 0.454887583948495 no 1508 0.45086976799104 2065 9614867
SGTC_543 3844-1095 191 µM 0.121638420271961 0.455619545509451 no 1509 0.45159269221197 2137 4230703
SGTC_3174 9107204 49.47 µM 0.121635105924108 0.455620874394205 no 1510 0.451594004699998 2155 3938802
SGTC_3180 9109287 49.47 µM 0.121567189665273 0.455648105465659 no 1511 0.451620899783638 2118 18891271
SGTC_2557 derrustone 83.84 µM 0.120931852609232 0.455902854376778 no 1512 0.451872506289392 2009 629853 An antioxidant.
SGTC_255 tunicamycin 200.472 nM 0.119811306150752 0.456352200152337 no 1513 0.452316312724908 2189 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2698 st077697 67.5 µM 0.119122926871885 0.456628272043993 no 1514 0.452588983527112 2059 3154499
SGTC_3272 9137413 49.47 µM 0.118119614484971 0.457030684119493 no 1515 0.452986441068608 2221 17614870
SGTC_2166 5933061 31.504 µM 0.117873367666567 0.457129456413613 no 1516 0.453083997816478 2146 2877375
SGTC_1480 1070-0044 41.2 µM 0.117571370995898 0.457250594198659 no 1517 0.453203645108065 2199 3124987
SGTC_1013 4112-3890 241 µM 0.116883500432089 0.457526529654577 no 1518 0.453476186635771 2054 705171
SGTC_1997 st073024 93.8 µM 0.115988833279644 0.457885451028073 no 1519 0.453830695906011 2214 686268
SGTC_2330 7979373 200 µM 0.115721950712787 0.457992525284142 no 1520 0.453936454487672 2052 1863007
SGTC_2053 5265679 138 µM 0.115336072020346 0.458147346607077 no 1521 0.454089373895474 2153 764595
SGTC_3299 9121982 43.1275 µM 0.115083328947434 0.458248755019388 no 1522 0.454189536837209 2084 17594604 YPL160W CDC60
SGTC_1609 st001574 46.4 µM 0.114712906585385 0.458397384945237 no 1523 0.454336341744799 2172 3960012
SGTC_1947 st076332 61.6 µM 0.114621536053015 0.458434047761614 no 1524 0.454372554456319 2209 24208416
SGTC_3162 9099653 49.47 µM 0.112174875980825 0.459415911085184 no 1525 0.45534237474183 2205 25237511
SGTC_989 1501-0895 10.3 µM 0.11131566337189 0.459760778699151 no 1526 0.455683017511747 2230 2830112
SGTC_1344 1488-0097 29.1 µM 0.111248554965578 0.459787715703906 no 1527 0.455709624633877 2139 747966
SGTC_2310 7668677 200 µM 0.11024132509176 0.460192035236187 no 1528 0.456108994650344 2155 2197143
SGTC_2351 9026858 72.31 µM 0.11005318847805 0.460267561109578 no 1529 0.456183596374866 2168 1409300
SGTC_3071 9117417 49.47 µM 0.105435861514571 0.462121591142029 no 1530 0.458014980632367 2222 45595590 YGL055W OLE1
SGTC_892 0929-0076 29 µM 0.104985507102152 0.462302470055119 no 1531 0.458193654409738 2110 5751038
SGTC_1690 st023502 41.2 µM 0.102976541347744 0.463109439102632 no 1532 0.458990794625163 2234 24207482
SGTC_674 0498-0004 451 µM 0.101468948769789 0.463715114559653 no 1533 0.459589102801693 2084 4231473
SGTC_3348 9149464 3.537 µM 0.100657289392943 0.464041233709438 no 1534 0.459911258617368 2247 1951442
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.0999393667182056 0.464329710241906 no 1535 0.460196231331594 2083 803109
SGTC_1484 3473-2379 286 µM 0.0990545123798311 0.464685289235224 no 1536 0.460547494129766 2233 671917
SGTC_2288 7946289 167.31 µM 0.0989424113938009 0.464730339070406 no 1537 0.460591997336347 2219 1246052
SGTC_2148 5546263 113.568 µM 0.0987529495542258 0.46480647880947 no 1538 0.460667213312957 2130 792097
SGTC_539 4859-0462 2.54 µM 0.0980536086965186 0.465087536674791 no 1539 0.46094486241777 2259 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_316 k060-0003 58.6 µM 0.0980195037724561 0.46510124353797 no 1540 0.460958403086535 2207 6152314
SGTC_2418 pentamidine 31.67 µM 0.0978936510520471 0.46515182445212 no 1541 0.461008370749637 2239 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1830 st055982 50.3 µM 0.0968552142009704 0.46556919946151 no 1542 0.461420687706301 2251 455313 An antimicrobial agent.
SGTC_3194 9111903 49.47 µM 0.09670883829705 0.465628034833222 no 1543 0.461478810394075 2197 17087251
SGTC_709 3807-1509 243 µM 0.0960148937337977 0.465906974047972 no 1544 0.461754371862498 2228 1886677 YPL242C IQG1
SGTC_2202 7226349 200 µM 0.0956077628017451 0.466070632940461 no 1545 0.461916049811702 2221 844334
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.0951299629787062 0.466262706699453 no 1546 0.462105799488295 2099 4174840
SGTC_2424 5537928 59.2 µM 0.0931248839355223 0.467068826211207 no 1547 0.462902174405793 2154 5382802
SGTC_2265 7929201 200 µM 0.093044452246067 0.467101165708929 no 1548 0.462934123292482 2254 1265108
SGTC_1677 st019204 53.9 µM 0.0929546722501773 0.467137264174871 no 1549 0.462969785773874 2057 3945625
SGTC_1254 0550-0035 264 µM 0.0916802679762003 0.467649701753404 no 1550 0.463476037614573 2192 15121435
SGTC_2058 5236698 133 µM 0.090978169473513 0.467932038311791 no 1551 0.463754968671845 2188 766665
SGTC_2289 7946404 165.07 µM 0.090653908500057 0.468062439610666 no 1552 0.463883797724353 2177 1246120 YPR165W RHO1
SGTC_2676 harmalol 100 µM 0.0901486656944447 0.468265629437666 no 1553 0.46408453849488 2233 5459187 A monoamine oxidase inhibitor
SGTC_147 4466-0538 29.23 µM 0.0900891843383827 0.468289551167283 no 1554 0.464108171958939 2142 6742687 YHR072W ERG7
SGTC_2333 9017922 200 µM 0.0900628647085961 0.468300136219186 no 1555 0.464118629461426 2228 3163164
SGTC_1713 st033146 12.748 µM 0.0897661698547818 0.468419460510896 no 1556 0.464236516083813 2240 674619
SGTC_142 0335-0849 62.6745 µM 0.0884640804252166 0.468943166291861 no 1557 0.464753916022196 2235 3889043 YPR107C YTH1
SGTC_2812 7970281 58.44 µM 0.0880899290846355 0.469093661495939 no 1558 0.464902600344433 2240 2233435
SGTC_2127 5253358 187.912 µM 0.0869422611394899 0.46955531638086 no 1559 0.465358703575373 2190 20612
SGTC_1341 1486-1360 280 µM 0.0865686504123301 0.469705611932534 no 1560 0.46550719283433 2223 3976547
SGTC_1699 st031318 29.054 µM 0.0864048530706513 0.469771505438795 no 1561 0.465572294584214 2212 5340658
SGTC_1627 st003713 25.6 µM 0.0861560930767299 0.469871579880164 no 1562 0.465671166759389 2158 16195070 YER133W GLC7
SGTC_2400 5203494 178.7 µM 0.0860050823092023 0.469932331406119 no 1563 0.465731188550079 2254 6777674
SGTC_185 k048-0037 25.491 µM 0.0857525815670428 0.470033913840622 no 1564 0.465831550993246 2254 6827589
SGTC_3326 9140064 16.379 µM 0.0856646503618047 0.4700692895053 no 1565 0.465866501858774 2237 1868434
SGTC_2180 6301957 200 µM 0.0848305335521707 0.470404875332366 no 1566 0.466198059380502 2250 845462
SGTC_487 nimodipine 119 µM 0.0836236886412941 0.470890456040299 no 1567 0.466677816044261 2265 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2930 9013230 14.89 µM 0.0828106293532535 0.471217619377407 no 1568 0.467001058579186 2227 2995857
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.081899571712579 0.471584238907041 no 1569 0.467363287510282 2245 279621
SGTC_244 nsc-207895 1.295 µM 0.0797302198125978 0.472457306130735 no 1570 0.468225912010548 2245 42640
SGTC_663 1486-0733 13.9 µM 0.0788919941481459 0.47279469019209 no 1571 0.468559265569527 2191 722445 YPR165W RHO1
SGTC_1187 1391-0724 117 µM 0.077196667941562 0.473477114822389 no 1572 0.469233546168027 2162 6997986
SGTC_2339 9000433 200 µM 0.0769869022222546 0.473561557885143 no 1573 0.469316982277162 2153 2988954
SGTC_551 k048-0028 34.9 µM 0.0767584703728127 0.473653516516372 no 1574 0.469407844531727 2253 6836383
SGTC_1785 bathophenanthroline 24 µM 0.076400594224184 0.473797587692271 no 1575 0.469550198433363 2114 72812 An iron chelator.
SGTC_1896 st058441 89 µM 0.0763293266747754 0.473826278473546 no 1576 0.469578547291707 2125 688759
SGTC_583 1488-1091 88.9 µM 0.0761475772748902 0.473899447483821 no 1577 0.469650844399766 2286 4303273
SGTC_2823 7987624 58.44 µM 0.07543557534554 0.474186094998262 no 1578 0.469934077401179 2204 2239440
SGTC_89 0302-0250 142.109 µM 0.075230313934462 0.474268734444287 no 1579 0.470015732827993 2285 4203518 YLR208W SEC13
SGTC_3169 9102970 49.47 µM 0.0750596422187009 0.47433744871964 no 1580 0.470083629023502 2285 17027839
SGTC_64 000l-0018 272.079 µM 0.0733923948417891 0.475008740355995 no 1581 0.470746934656519 2200 6811119
SGTC_2352 9027995 87.8 µM 0.0732076462440901 0.475083130952475 no 1582 0.470820440947079 2216 2997347
SGTC_2133 5320837 200 µM 0.0725892527274562 0.475332138674357 no 1583 0.47106648961959 2259 2841355
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.0718296829211244 0.475638006846944 no 1584 0.471368725135658 2263 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_292 k038-0015 474 µM 0.070628784351907 0.476121621182124 no 1585 0.471846600506667 2248 46368540
SGTC_2841 9004761 38.96 µM 0.0690968099581931 0.476738614158069 no 1586 0.472456280123049 2194 2991039
SGTC_1059 3448-6867 171 µM 0.0686084442444241 0.47693531214697 no 1587 0.472650648586422 2303 3934407
SGTC_863 0466-0191 129 µM 0.0684126886201464 0.477014157791432 no 1588 0.472728560718724 2293 765160 YPR165W RHO1
SGTC_540 1187-0821 17.3 µM 0.067679077194293 0.477309646761254 no 1589 0.473020552547797 2177 847520
SGTC_2785 7756463 72.73 µM 0.0672711863115755 0.477473945215571 no 1590 0.473182907452296 2258 2201551
SGTC_404 fumagillin 50 µM 0.0669001024056453 0.47762342114592 no 1591 0.473330615757446 2174 12015870 A methionine aminopeptidase binder.
SGTC_1119 parthenolide 318.541 nM 0.0668497822068826 0.477643690816803 no 1592 0.473350645772477 2224 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2378 9074213 121.43 µM 0.0663748487368887 0.477835003418008 no 1593 0.473539696917721 2276 657714
SGTC_2621 lithochol-11-enic acid 100 µM 0.0662443918248147 0.477887554940177 no 1594 0.47359162740181 2287 6708711
SGTC_172 1112-0046 2.638 µM 0.0654654743797443 0.478201331622691 no 1595 0.473901697399272 2219 2802135 YIL048W NEO1
SGTC_1782 st039423 80.636 µM 0.063977283038732 0.478800867404076 no 1596 0.474494157626069 2138 2068169
SGTC_1015 4130-4525 82 µM 0.0619092211615519 0.479634090364223 no 1597 0.475317562080607 2181 1363237
SGTC_1462 k081-0014 26.5 µM 0.0618543293680372 0.479656207518474 no 1598 0.475339418849142 2284 3270634
SGTC_1020 4335-0961 93.3 µM 0.0615911472594029 0.479762250455227 no 1599 0.475444213511253 2135 669075
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.0611857380375959 0.479925603205922 no 1600 0.47560564392428 2218 5282362
SGTC_961 1252-1571 372 µM 0.0606869054778959 0.48012660392515 no 1601 0.475804280186973 2297 6813498
SGTC_2068 5226020 147 µM 0.0602662672522499 0.480296100771937 no 1602 0.475971783962831 2258 1810509
SGTC_1 0258-0098 57.368 µM 0.0597443389537087 0.480506417565178 no 1603 0.476179628702405 2199 6790032 YDR047W HEM12
SGTC_3155 9099265 49.47 µM 0.0595992439137322 0.480564886186322 no 1604 0.476237410284753 2256 25236499
SGTC_3192 9110362 49.47 µM 0.0579960691724403 0.481210941450269 no 1605 0.4768758798022 2296 16649480
SGTC_1516 st013856 110 µM 0.0579719292428074 0.481220669859572 no 1606 0.476885494064915 2230 5281404 A mutagen and neurotoxin.
SGTC_1031 k035-0009 16 µM 0.0574514629396503 0.481430420870805 no 1607 0.477092784583802 2304 5180959
SGTC_1727 st034309 9.9045 µM 0.0573980000996991 0.481451967004959 no 1608 0.477114078033489 2305 870305
SGTC_2846 9008642 19.48 µM 0.0560517034072177 0.481994557618196 no 1609 0.477650309253328 2193 2992898
SGTC_1368 1852-0141 284 µM 0.0555077900755988 0.482213777557893 no 1610 0.477866961968735 2248 2838987
SGTC_1268 0828-0275 2.46 µM 0.0547029788635482 0.482538160158514 no 1611 0.47818754806421 2271 745337
SGTC_3069 9117009 49.47 µM 0.0540425630172924 0.482804352234008 no 1612 0.478450626692995 2311 41904981
SGTC_804 1595-0054 20.9 µM 0.0527063363218233 0.483342964929883 no 1613 0.478982945195231 2192 761523 Stimulates phospholipase C.
SGTC_2973 9094665 17.96 µM 0.0507470610221353 0.484132773748872 no 1614 0.479763537830808 2291 25237061 YIL048W NEO1
SGTC_3317 9138495 8.753 µM 0.0502108075697092 0.484348955326312 no 1615 0.479977199611722 2313 17020139
SGTC_1138 3761-0006 1.03 µM 0.0496916053335819 0.484558267376286 no 1616 0.480184073085031 2305 12061087
SGTC_770 0389-1121 67.2 µM 0.0488957453402799 0.484879119933272 no 1617 0.480501189767553 2308 6753108
SGTC_1331 1472-0049 76.2 µM 0.0488577639771407 0.484894432442623 no 1618 0.480516324050949 2326 24051409
SGTC_1773 st048542 73.5835 µM 0.0481475332621658 0.485180772069854 no 1619 0.480799332021089 2280 3237138
SGTC_1564 D-Arginine 115 µM 0.0476522326111932 0.485380464112447 no 1620 0.480996701837797 2256 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1523 st012844 44.7 µM 0.0475049030160103 0.485439864194548 no 1621 0.48105541135384 2207 4274103
SGTC_2048 5246248 200 µM 0.0471938520803622 0.485565274212727 no 1622 0.481179363696704 2344 677046
SGTC_401 neomycin 50 µM 0.0466375640865639 0.485789562855487 no 1623 0.481401046389278 2230 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2975 9084847 53.72 µM 0.0439031981290371 0.486892090403876 no 1624 0.482490783011219 2183 27211724
SGTC_1770 st043884 66.3 µM 0.0436790592368377 0.486982470319677 no 1625 0.482580115795649 2334 670149
SGTC_262 fenpropimorph 62.5 µM 0.0429022186476761 0.487295722248028 no 1626 0.482889740077798 2318 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_848 0368-0089 85.6 µM 0.0425407823752132 0.487441469902826 no 1627 0.483033800763273 2330 762535
SGTC_1492 4158-0558 28.5 µM 0.0424259852811467 0.487487761699474 no 1628 0.483079556867925 2329 3967268
SGTC_3079 9117512 49.47 µM 0.0403217898077523 0.488336305340059 no 1629 0.483918291074582 2342 7185044
SGTC_2485 5633444 17.78 µM 0.0402616060702111 0.488360575994185 no 1630 0.483942281430947 2285 5724239
SGTC_2529 gangaleoidin 93.61 µM 0.040186333202804 0.488390931792202 no 1631 0.483972286676735 2316 4565183
SGTC_2723 salbutamol 83.58 µM 0.0401765179516676 0.48839489005983 no 1632 0.483976199235626 2325 9884233 β2-adrenoceptor agonist
SGTC_1103 duloxetine 36.1 µM 0.04003734404844 0.48845101585364 no 1633 0.484031676952177 2310 60835 A selective serotonin reuptake inhibitor.
SGTC_375 3970-0961 9.27 µM 0.0394640893558222 0.488682199342903 no 1634 0.484260191871599 2295 2898222
SGTC_3323 9138564 53.9225 µM 0.0391944250190798 0.488790951525382 no 1635 0.484367689206632 2335 43912313 YNL103W MET4
SGTC_1743 st037606 46.3785 µM 0.0387434680939179 0.488972818551183 no 1636 0.48454745844049 2310 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_808 0711-0032 135 µM 0.0383885856195424 0.489115941196373 no 1637 0.48468893081557 2342 4252555
SGTC_2062 5245942 200 µM 0.0379125907492583 0.489307910171031 no 1638 0.484878687150453 2341 1376160
SGTC_281 1672-3440 14.9 µM 0.0354728048058838 0.490291915015952 no 1639 0.485851365672025 2326 6833000
SGTC_274 sirtinol 40.1 µM 0.0353709533276705 0.49033299467891 no 1640 0.485891973049763 2298 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_814 3342-0569 96 µM 0.0353516856687667 0.490340765897587 no 1641 0.485899654929244 2346 4346283
SGTC_1096 rimcazole 32.2 µM 0.0351756296659648 0.490411774678105 no 1642 0.485969847455718 2339 18528119 A dopamine reuptake inhibitor.
SGTC_2970 9090938 41.86 µM 0.0343339618549833 0.49075124925595 no 1643 0.48630542159116 2337 17217104
SGTC_2607 solasodine 47.35 µM 0.0336414585921696 0.491030565498304 no 1644 0.486581530894609 2303 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_962 1254-0300 21.5 µM 0.0327514864568078 0.491389535838635 no 1645 0.486936382817766 2328 7340576
SGTC_2279 7948423 32.93 µM 0.0324472053764033 0.491512269253997 no 1646 0.48705770892059 2340 1247112
SGTC_457 grayanotoxin iii 135 µM 0.0311551298417967 0.492033443702488 no 1647 0.487572911863078 2303 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_902 1120-0002 2.07 µM 0.0304604405399839 0.492313660795875 no 1648 0.487849921303001 2338 3280475
SGTC_395 anisomycin 6.25 µM 0.0285195977529353 0.493096558968779 no 1649 0.488623868819693 2266 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3083 9117465 49.47 µM 0.0284553028780737 0.493122494740529 no 1650 0.488649508357884 2213 16420915
SGTC_819 1013-0258 27.7 µM 0.0281715394221171 0.493236961818588 no 1651 0.488762668231331 2331 5753198
SGTC_2741 miltefosine 3.04 µM 0.027628264870467 0.493456114383223 no 1652 0.488979319079774 2337 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_866 0495-0101 262 µM 0.0274469727329457 0.493529246609501 no 1653 0.489051616760834 2339 635694
SGTC_742 0kpi-0133 140 µM 0.0256383419843699 0.494258849562764 no 1654 0.489772901815819 2348 2728852
SGTC_3056 9094900 49.47 µM 0.0254074340921916 0.494351999407203 no 1655 0.489864990737615 2353 25236784
SGTC_1129 3453-1384 223 µM 0.0244316822016843 0.494745627824083 no 1656 0.490254138560368 2311 1084452
SGTC_1176 0848-0131 83.3 µM 0.0243812269535078 0.494765982136084 no 1657 0.490274261297933 2346 6769040
SGTC_478 N-arachidonylglycine 10 µM 0.0238431551746072 0.494983048219155 no 1658 0.490488858485609 2365 5283389
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.0234113381776466 0.495157250635185 no 1659 0.490661080463863 2358 688798
SGTC_1954 st077032 68.9 µM 0.0230852118352467 0.495288816234188 no 1660 0.49079115089489 2208 698907
SGTC_101 0490-5701 117.494 µM 0.0214415273700717 0.49595191746568 no 1661 0.491446723559978 2356 4661669
SGTC_1693 xanthone 101.9 µM 0.021301050965597 0.496008589518067 no 1662 0.491502752740455 2315 7020 An insecticide.
SGTC_2353 9059630 146.67 µM 0.021074746978535 0.496099886951165 no 1663 0.491593014706131 2343 4779114
SGTC_785 1270-0111 65.3 µM 0.0206621508080827 0.496266340445704 no 1664 0.491757580924539 2375 6741994
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.0198178457644575 0.496606960058709 no 1665 0.4920943409088 2249 61125 An anti-inflammatory.
SGTC_1983 st071813 46.9 µM 0.0195317644487256 0.496722374969452 no 1666 0.492208448753295 2272 11838595
SGTC_2269 7935389 174.42 µM 0.0194262486905043 0.49676494367669 no 1667 0.492250535465205 2365 97605
SGTC_1340 1486-1359 257 µM 0.0188739751606726 0.496987750514597 no 1668 0.492470820327919 2284 4309068
SGTC_1902 st060212 70.5 µM 0.0176610144876412 0.497477105309216 no 1669 0.492954640862679 2376 688944
SGTC_65 0798-0905 34.986 µM 0.0154241445474939 0.498379553732234 no 1670 0.493846900576684 2376 3602145
SGTC_474 dl-dihydrosphingosine 5 µM 0.0153311522500944 0.498417070989571 no 1671 0.493883994749728 2372 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_3000 9075062 71.4286 µM 0.0152042588476597 0.498468265493425 no 1672 0.493934611993174 2373 17057871
SGTC_634 1611-4317 11.2 µM 0.01493337400022 0.49857755270359 no 1673 0.494042667142911 2380 2843522
SGTC_70 0141-0289 43.283 µM 0.0139919111438392 0.498957382216592 no 1674 0.494418217189295 2301 352408
SGTC_2663 amphotericin b 100 µM 0.0132266829650544 0.499266111249238 no 1675 0.494723470786749 2378 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2878 9043973 25.97 µM 0.0131288486855152 0.499305582233884 no 1676 0.494762497628593 2360 6465167
SGTC_677 0929-0063 136 µM 0.0123589526295631 0.499616194993898 no 1677 0.495069616769079 2379 1539583
SGTC_2726 cimetidine 79.27 µM 0.0115868339028778 0.499927704718702 no 1678 0.495377625489651 2383 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2261 9010538 184.68 µM 0.0112284468230299 0.499927704718702 no 1679 0.495520591945067 2318 6457250
SGTC_1029 k015-0030 64.7 µM 0.0105466262943169 0.499652625609188 no 1680 0.49579258285518 2334 2208316
SGTC_672 1441-0018 53.7 µM 0.0104636572167373 0.499619151911766 no 1681 0.495825680901815 2389 251141
SGTC_1215 3852-0577 11.2 µM 0.00989696977422187 0.499390523155459 no 1682 0.496051744764587 2386 2884876
SGTC_1844 rapamycin 4 nM 0.00920022443456059 0.499109423119381 no 1683 0.496329693262264 2386 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_660 4031-1742 102 µM 0.00854198534557721 0.498843858730539 no 1684 0.496592282328109 2388 6738706
SGTC_575 k072-0246 11.9 µM 0.0082654750739809 0.498732301719724 no 1685 0.496702590070879 2388 6796779
SGTC_330 1488-0319 80.1 µM 0.00794387306690368 0.498602552746095 no 1686 0.496830886494719 2373 6846614
SGTC_1796 st049173 110.4 µM 0.00747320721830362 0.498412664864462 no 1687 0.497018649421265 2391 94134
SGTC_1550 gossypolone 36.6 µM 0.0074487624475307 0.498402802748262 no 1688 0.497028401202434 2396 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_744 1594-0068 283 µM 0.00594912385558601 0.497797783421645 no 1689 0.497626656962259 2390 668392
SGTC_1922 5578187 25 µM 0.00567427488537677 0.497686897920473 no 1690 0.497736303985129 2393 1350412
SGTC_514 4466-0038 2.65 nM 0.00532146357079919 0.497544559431486 no 1691 0.497877053207589 2374 5722064
SGTC_210 3551-0445 56.827 µM 0.00476425387559112 0.497319758934319 no 1692 0.498099344884678 2372 2865180 YOR207C RET1
SGTC_1748 st037455 53.6035 µM 0.00327218078811355 0.496717801843216 no 1693 0.498694591064043 2397 580690
SGTC_1970 st070122 35.8 µM 0.00253479109326117 0.496420314427976 no 1694 0.498988765743805 2399 102928
SGTC_2192 5915882 198.485 µM 0.00227425321676465 0.496315205290509 no 1695 0.499092705017616 2395 2876149
SGTC_402 epigallocatechin gallate 10 µM 0.00169535569273882 0.496081660828852 no 1696 0.499323651257844 2399 65064 An antioxidant.
SGTC_3250 9135583 49.47 µM 0.00166609631811659 0.496069856762742 no 1697 0.499335324042992 2401 7699353
SGTC_1112 tnp00069 1.16933 µM 0.000986095973424584 0.495795526222999 no 1698 0.499606604687423 2403 145826
SGTC_1920 st075728 45.7 µM 0.00045856361289135 0.495582706756667 no 1699 0.499817059592975 2400 3400306
SGTC_2774 tamoxifen 10.92 µM 0.000366999071642877 0.495545767505899 no 1700 0.49985358855674 2403 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_163 TUB2.036 7.546 µM 0 0.495397711990464 no 1701 0.5 2405 15992207 YJR013W GPI14
SGTC_1482 3346-2049 8.48 µM -0.000400201833917812 0.495236262472073 no 1702 0.499840342572018 2407 3826804
SGTC_2073 5212005 126 µM -0.0022474176725468 0.494491068747434 no 1703 0.499103410823461 2409 691789
SGTC_1056 3448-1962 115 µM -0.00282587343653458 0.494257715112553 no 1704 0.498872641107535 2418 715507
SGTC_619 1652-1634 108 µM -0.00374565030364344 0.493886673920883 no 1705 0.498505705220412 2410 5400454
SGTC_765 1319-0117 244 µM -0.00483700531892626 0.493446424393347 no 1706 0.498070321592415 2416 3487746 YGL099W LSG1
SGTC_2834 9001755 58.44 µM -0.00508843756934615 0.493344998446256 no 1707 0.497970015872533 2431 2989575
SGTC_1348 1493-0373 93.8 µM -0.00579921272198867 0.493058279251157 no 1708 0.49768646181988 2422 3010129
SGTC_2186 6124449 200 µM -0.00728100706306524 0.492460550756518 no 1709 0.497095324102959 2417 3834182 YLR033W RSC58
SGTC_3142 9086498 49.47 µM -0.00741997622668324 0.492404494007692 no 1710 0.497039884925667 2421 25236367
SGTC_3310 9130229 44.1445 µM -0.00778697340189239 0.492256457081259 no 1711 0.496893478468656 2448 7761258
SGTC_791 1348-1292 225 µM -0.00798830221690589 0.492175246828939 no 1712 0.496813162390684 2450 5437054
SGTC_2460 5552655 174.22 µM -0.00825018159284598 0.492069612708021 no 1713 0.496708691079096 2444 5401989
SGTC_505 gw-5074 63.9 µM -0.00872572331476192 0.491877795166599 no 1714 0.496518984215786 2446 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1201 1889-3372 45.9 µM -0.0105294344757095 0.491150256178485 no 1715 0.495799441017689 2437 5392199
SGTC_3234 9132280 49.47 µM -0.0115025937759934 0.490757737923929 no 1716 0.495411230198462 2453 17612295
SGTC_3003 9075612 71.4286 µM -0.0121740570885216 0.490486912220911 no 1717 0.495143373868535 2445 6501993
SGTC_3002 9075603 71.4286 µM -0.0123231047285827 0.490426796448823 no 1718 0.495083916923438 2429 20105405
SGTC_1131 3454-3128 32.3 µM -0.0124966419248624 0.490356803514454 no 1719 0.495014690929485 2473 710982
SGTC_1994 st072947 40.9 µM -0.0137614333968867 0.489846682985343 no 1720 0.494510155654688 2490 5286565 YDL195W SEC31
SGTC_2282 7944268 200 µM -0.0167117962255942 0.488656797371064 no 1721 0.493333268224336 2440 2970414
SGTC_787 4152-0075 138 µM -0.0171716422983081 0.488471349607359 no 1722 0.493149842510553 2455 9566539
SGTC_890 0929-0006 47.2 µM -0.0180637222997841 0.48811159671145 no 1723 0.492794009318784 2440 1378169
SGTC_1294 1000-1494 117 µM -0.0182383977139382 0.488041155737612 no 1724 0.492724335389186 2450 712797 YDL207W GLE1
SGTC_2184 6075246 200 µM -0.019057807820032 0.487710719024566 no 1725 0.492397494896635 2450 2267320
SGTC_5 0352-0601 109.883 µM -0.0199825505549336 0.487337815840711 no 1726 0.492028646213594 2386 762456
SGTC_769 0302-0231 76 µM -0.0201230348428033 0.487281166409501 no 1727 0.491972612358622 2452 571869 YER009W NTF2
SGTC_1578 josamycin 24.2 µM -0.0209400035637412 0.486951733883642 no 1728 0.491646757691295 2447 5282165 A P450 substrate.
SGTC_3136 9095672 49.47 µM -0.0217912332290991 0.48660849553077 no 1729 0.491307243698856 2436 17217380
SGTC_898 1000-0849 28.3 µM -0.0220540805958431 0.48650251050152 no 1730 0.491202407966476 2433 6751807
SGTC_2829 7992743 58.44 µM -0.022328377995935 0.486391909618939 no 1731 0.491093006077351 2439 16462845
SGTC_562 3772-2733 112 µM -0.0230089807702062 0.486117484770185 no 1732 0.490821554613984 2456 2876874 YIL048W NEO1
SGTC_851 0394-0702 453 µM -0.0238367446502181 0.485783732179873 no 1733 0.490491415188182 2440 762646
SGTC_1314 1222-0010 41.1 µM -0.0241560896298947 0.485654975629965 no 1734 0.490364051649324 2465 3526027
SGTC_1752 st044819 83.042 µM -0.0241607915153006 0.485653079890172 no 1735 0.490362176415739 2463 441209 YML126C ERG13
SGTC_644 1498-1197 63.3 µM -0.0252441148055922 0.485216306587144 no 1736 0.489930124814492 2479 6741615
SGTC_300 r073-0011 5.04 µM -0.0264364582533684 0.484735599159136 no 1737 0.489454607411414 2456 2735780
SGTC_1365 1672-3266 55.4 µM -0.0266216222478076 0.484660950067046 no 1738 0.48938076365515 2447 6415873
SGTC_2825 7998094 58.44 µM -0.0267929676198651 0.484591872448416 no 1739 0.489312431116218 2473 2987815
SGTC_2804 7954240 19.48 µM -0.0270955973078634 0.484469868894139 no 1740 0.489191743156173 2474 828705
SGTC_1233 0325-0408 14.2 µM -0.0277898445343902 0.484189992317359 no 1741 0.488914882861798 2471 12874
SGTC_1428 4049-0204 61.7 µM -0.0282356611908342 0.484010271333662 no 1742 0.488737097518746 2459 X1428
SGTC_1044 1222-0021 1.78 µM -0.0285562334611641 0.483881041820158 no 1743 0.488609259237035 2558 4306703
SGTC_2487 5918373 44.05 µM -0.0310206393759754 0.482887644829665 no 1744 0.48762653987533 2464 2876279
SGTC_2964 9083345 53.42 µM -0.0324735936458644 0.482302011311686 no 1745 0.487047187068975 2484 17741579
SGTC_1751 st044839 27.194 µM -0.0326193449967927 0.482243266279879 no 1746 0.486989071480995 2460 5291326
SGTC_2479 5617353 43.85 µM -0.0333662583763502 0.481942229176966 no 1747 0.486691258293673 2500 2731746
SGTC_103 0844-0104 51.839 µM -0.0340114321214717 0.481682205652301 no 1748 0.486434017230791 2529 5375804
SGTC_10 0279-0212 42.575 µM -0.0357649793261633 0.480975515523991 no 1749 0.485734878820239 2474 39851 YBR002C RER2
SGTC_475 α-linolenic acid 10 µM -0.0363794194105157 0.480727906484332 no 1750 0.485489912123294 2499 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2800 7887935 81.82 µM -0.0371799530554954 0.480405316032393 no 1751 0.48517076135182 2510 2961002
SGTC_522 1273-0010 11.6 µM -0.0372254471756844 0.480386983683723 no 1752 0.485152624379268 2663 5705015
SGTC_1385 3091-4834 14.1 µM -0.0375370845057679 0.480261407162241 no 1753 0.485028385905856 2505 4072814
SGTC_2983 9022671 12.99 µM -0.0379957641222114 0.480076582452402 no 1754 0.484845529665994 2512 6405161
SGTC_1206 3978-0017 132 µM -0.0381355312784086 0.480020264200054 no 1755 0.484789811020626 2640 3873677
SGTC_3134 9127454 49.47 µM -0.0383291641896415 0.479942241756784 no 1756 0.484712619102392 2458 24262820
SGTC_1857 st056007 79.3 µM -0.0383846119580233 0.479919899774964 no 1757 0.484690514909622 2483 619834
SGTC_2469 5655019 90.81 µM -0.0384042451104225 0.479911988857926 no 1758 0.484682688185972 2541 2788239
SGTC_702 1488-0190 94 µM -0.0387628104547659 0.479767511127272 no 1759 0.484539747747101 2477 949357
SGTC_3294 9122953 26.2835 µM -0.0387860962119493 0.479758128624129 no 1760 0.484530465054724 2468 16459826
SGTC_2706 st078239 82.5 µM -0.0407444635975001 0.478969086573663 no 1761 0.483749807091212 2474 15434492
SGTC_231 b-estradiol 524 µM -0.0410530910778683 0.478844745505288 no 1762 0.48362678547367 2470 450 A steroid.
SGTC_2616 abietic acid 100 µM -0.0412136524814803 0.478780058701002 no 1763 0.483562784907161 2484 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2413 inermin 26.06 µM -0.0415198123710616 0.478656714886948 no 1764 0.483440749241917 2507 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_347 4534-1311 26.2 µM -0.0417061245189353 0.478581655593948 no 1765 0.483366485775491 2482 2862016
SGTC_2517 totarol 10 µM -0.0421896860140144 0.478386847457327 no 1766 0.483173742304711 2530 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1386 3228-0095 33.8 µM -0.0428171437114974 0.478134076836042 no 1767 0.482923648908073 2507 870181
SGTC_407 eburnamonine 100 µM -0.0443674812641987 0.477509563039667 no 1768 0.482305741152109 2489 3195
SGTC_2931 9014674 55.67 µM -0.0451076760301183 0.477211413910293 no 1769 0.482010741532376 2476 2996810
SGTC_3018 9082602 49.47 µM -0.0463126759180868 0.476726069467395 no 1770 0.481530518114616 2488 17332089
SGTC_2523 spermine 47.74 µM -0.0468269226061983 0.476518953964396 no 1771 0.48132558571414 2500 1103 A DNA binding polyamine.
SGTC_1824 st053723 68.6 µM -0.0471480863311252 0.476389606833882 no 1772 0.481197601287541 2512 675225
SGTC_2533 agelasine 13.65 µM -0.0480382862522112 0.476031096184979 no 1773 0.480842864899018 2518 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1181 1222-0449 220 µM -0.0503075046889401 0.475117301179472 no 1774 0.479938671733603 2536 658318
SGTC_2314 7727897 200 µM -0.0503476224571678 0.475101147257855 no 1775 0.479922687315662 2510 900724
SGTC_196 k015-0023 18.111 µM -0.0507831359919814 0.474925784920381 no 1776 0.47974916453269 2492 5211998
SGTC_612 0302-0167 22.4 µM -0.051295018191281 0.474719678459323 no 1777 0.479545218894007 2536 235821
SGTC_45 0kpi-0036 14.9 µM -0.0530842056657008 0.473999325792216 no 1778 0.478832407880666 2541 2795021
SGTC_2442 5158906 48.48 µM -0.0555255411547465 0.473016546518819 no 1779 0.477859891217522 2580 1893835
SGTC_2568 diosmetin 100 µM -0.0558826084147225 0.472872819840183 no 1780 0.477717662825954 2499 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2526 patulin 37.61 µM -0.0588498930209208 0.471678567111712 no 1781 0.476535834204242 2571 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2940 9060638 45.86 µM -0.0591792819935395 0.471546012360191 no 1782 0.476404655645159 2557 4027022
SGTC_764 1951-2361 146 µM -0.0591947753121058 0.471539777520425 no 1783 0.476398485522082 2518 5438930
SGTC_626 0214-0009 33 µM -0.059257495670804 0.471514537590039 no 1784 0.476373507565627 2571 3437874
SGTC_3298 9116858 71.43 µM -0.0596790093813521 0.471344914991263 no 1785 0.476205645009244 2583 2506942
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.0598974226179427 0.471257024707031 no 1786 0.476118666332079 2596 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2088 5278280 127.392 µM -0.0600459746827495 0.471197247613105 no 1787 0.47605950911092 2550 791502
SGTC_757 1066-0008 322 µM -0.0608988944194788 0.47085404678625 no 1788 0.475719864969467 2661 6842497
SGTC_1932 st074806 40.9 µM -0.061092877390943 0.470775994251921 no 1789 0.475642620787744 2718 17251235
SGTC_942 3253-1115 227 µM -0.0614315254347865 0.470639735818629 no 1790 0.475507773048742 2573 46497897
SGTC_2146 5545642 200 µM -0.0630128407986042 0.470003523496356 no 1791 0.47487813958191 2517 825326
SGTC_1423 4048-0112 5.59 µM -0.0633498213842146 0.469867955574497 no 1792 0.474743971837502 2545 X1423
SGTC_2229 7354935 190 µM -0.0638451158267814 0.469668704034914 no 1793 0.474546777139225 2514 318112
SGTC_763 3453-1109 128 µM -0.06386537076134 0.469660555857485 no 1794 0.47453871304685 2515 1560353
SGTC_1427 4048-4900 550 nM -0.0640157408920663 0.469600065192847 no 1795 0.474478846548156 2573 24132586
SGTC_1037 k284-1091 78.7 µM -0.0644763774151719 0.469414765414369 no 1796 0.474295458028823 2503 3334711
SGTC_419 nsc-638432 893 µM -0.0667978605466096 0.468481006426527 no 1797 0.473371313321798 2575 368090
SGTC_2238 6671620 73.2395 µM -0.0675429644995127 0.468181343354491 no 1798 0.473074729686356 2514 729941
SGTC_3103 9120822 49.47 µM -0.0675918794683195 0.468161671547261 no 1799 0.473055259931106 2548 17141819
SGTC_1016 4226-1401 38 µM -0.0678599696459208 0.468053856887986 no 1800 0.472948552428491 2521 2901613
SGTC_1669 st015249 58.4 µM -0.0687777755082553 0.467684771538571 no 1801 0.472583254381671 2552 722793
SGTC_2242 6630449 61.2675 µM -0.0704277148292203 0.467021336984207 no 1802 0.4719266163839 2707 691249 YDR170C SEC7
SGTC_900 1112-0045 141 µM -0.0720772751827094 0.466358146387286 no 1803 0.471270205477911 2548 56211 YIL048W NEO1
SGTC_2956 9076196 2.52 µM -0.0724330705188632 0.466215114320989 no 1804 0.471128633718294 2541 16423868
SGTC_1141 3253-0389 52.6 µM -0.0733116461057805 0.465861939883464 no 1805 0.470779062193617 2519 5402031
SGTC_2455 5377712 9.75 µM -0.0734546943600239 0.465804439131109 no 1806 0.470722147648369 2602 2243908
SGTC_2080 5212524 12.4 µM -0.0744046057802902 0.465422623757772 no 1807 0.470344222040661 2545 260183
SGTC_1674 st016616 23.6 µM -0.0751461981496825 0.465124563999434 no 1808 0.47004919545049 2521 625830
SGTC_1702 st027038 51 µM -0.0754468253311405 0.465003741911041 no 1809 0.469929602059829 2587 5521182
SGTC_119 0121-0043 24.815 µM -0.0764115512955575 0.464616040312897 no 1810 0.469545839935121 2541 1092378
SGTC_194 1486-1323 56.904 µM -0.0765635225176056 0.464554969560855 no 1811 0.469485389276731 2562 5178754
SGTC_3273 9137859 49.47 µM -0.0772982746921153 0.464259715805226 no 1812 0.469193131699373 2530 2377234
SGTC_2766 oltipraz 83.91 µM -0.0776558700336849 0.464116026344628 no 1813 0.469050899329257 2586 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_534 k292-0788 63.4 µM -0.0779952480320262 0.463979661330721 no 1814 0.468915916500123 2529 4146317
SGTC_1295 1013-0063 9.78 µM -0.0781412491073942 0.463920998137166 no 1815 0.468857847722599 2556 6826038
SGTC_1760 st045453 10.4495 µM -0.0786580214832691 0.463713365443216 no 1816 0.468652317990932 2540 3323419 YIL048W NEO1
SGTC_233 rapamycin 362 pM -0.0789649500695038 0.463590050040748 no 1817 0.468530250885242 2566 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2869 9037858 32.47 µM -0.0791002098675505 0.463535707511061 no 1818 0.468476458293875 2532 27187042
SGTC_1736 st036774 51 µM -0.0795885869100242 0.463339500823542 no 1819 0.468282236373316 2596 1272247
SGTC_1648 st011736 69.8 µM -0.0798632047037552 0.463229176358026 no 1820 0.468173027355088 2643 2855514
SGTC_2217 6934799 96.0675 µM -0.0801919140367267 0.463097124972607 no 1821 0.468042310557697 2559 675606
SGTC_173 1273-0061 2.693 µM -0.0811886091537353 0.462696750637794 no 1822 0.46764597909454 2631 2847414 YPL266W DIM1
SGTC_1252 0493-0875 34.8 µM -0.0821691418181513 0.462302905663006 no 1823 0.467256105852153 2562 3960963
SGTC_2915 7971052 15.16 µM -0.0822837133027087 0.462256888790888 no 1824 0.467210552700106 2545 5741558
SGTC_1539 benzyladenosine 56 µM -0.0824643934230419 0.462184320853177 no 1825 0.467138715898646 2557 92208 A nucleotide analog.
SGTC_412 gemfibrozil 100 µM -0.0825712131100895 0.462141418637746 no 1826 0.467096245848817 2533 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_177 1327-0068 8.361 µM -0.0842114167963356 0.461482715788503 no 1827 0.466444170571146 2551 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1974 st069448 26.9 µM -0.0842562583860796 0.461464708962177 no 1828 0.466426344717629 2592 6323587 YNR016C ACC1
SGTC_228 caffeine 993.056 µM -0.0847094237807824 0.461282737905115 no 1829 0.466246201902867 2582 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_3232 9132874 49.47 µM -0.0861510305112692 0.460703906884875 no 1830 0.465673178949249 2568 3784940
SGTC_2499 avocadenofuran 51.48 µM -0.0865989917866064 0.460524059275975 no 1831 0.465495133664449 2566 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_463 ikarugamyin 104 µM -0.0870029909075336 0.460361868528433 no 1832 0.465334567362098 2555 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_353 1988-1175 58.3 µM -0.0870190469360458 0.460355422761209 no 1833 0.465328186135118 2508 2788357
SGTC_3319 9138450 16.7555 µM -0.087062089660459 0.46033814311097 no 1834 0.465311079495843 2587 2029690
SGTC_1759 st043059 70 µM -0.0873629883744489 0.46021734837779 no 1835 0.465191493928563 2583 669426
SGTC_2195 6536160 144.242 µM -0.0876811689072756 0.460089619913162 no 1836 0.465065043502761 2566 3834386
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.0886817861552159 0.459687965092081 no 1837 0.464667404018869 2646 7104
SGTC_280 3448-3607 3.04 µM -0.0890037508116598 0.459558734936429 no 1838 0.464539464618054 2567 626179
SGTC_893 0958-0369 48.9 µM -0.0896178836900966 0.459312246175539 no 1839 0.464295436230908 2716 6819948
SGTC_872 0588-0139 234 µM -0.0904542103114141 0.458976602762784 no 1840 0.463963139803184 2595 2047100
SGTC_1981 st071826 47 µM -0.0909836329411293 0.458764144393515 no 1841 0.463752798065853 2641 11838600
SGTC_2802 7925815 54.55 µM -0.0911833874005896 0.458683985583126 no 1842 0.46367343744614 2589 1262923
SGTC_533 1222-0222 6.71 µM -0.0932860928519373 0.457840300367006 no 1843 0.462838140099506 2754 3982874
SGTC_479 n-linoleoylglycine 10 µM -0.0939972321608434 0.457555007081906 no 1844 0.462555677709273 2581 6433346 An anti-infammatory.
SGTC_3201 9113999 49.47 µM -0.0947714309476337 0.457244440605459 no 1845 0.462248189755391 2757 16649224
SGTC_2009 4012297 12.05 µM -0.0951758005422506 0.457082239868821 no 1846 0.462087595542893 2648 45595307
SGTC_959 1222-0044 107 µM -0.0952769478266563 0.457041668785654 no 1847 0.462047426157373 2591 6083612
SGTC_3335 9143315 29.6265 µM -0.0953584133539642 0.457008992557335 no 1848 0.462015073418234 2631 4899691
SGTC_2181 6316240 54.2555 µM -0.0956790311132181 0.456880394004056 no 1849 0.461887747614928 2631 12779990
SGTC_2267 7931562 200 µM -0.0966332968521402 0.456497668449314 no 1850 0.46150880658078 2545 934880
SGTC_2679 rapamycin 1 nM -0.0977197729841551 0.456061966668733 no 1851 0.461077407065529 2613 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_245 methotrexate 289.6 µM -0.0982789468207781 0.455837745728564 no 1852 0.460855397622021 2632 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2788 5282734 71.43 µM -0.0988696110426817 0.455600912857484 no 1853 0.460620898765492 2667 743706
SGTC_875 0709-0210 25.7 µM -0.0994647716868741 0.455362293057086 no 1854 0.460384628641042 2575 6251364
SGTC_3290 9121031 71.43 µM -0.0998386295100498 0.455212409185734 no 1855 0.46023621966661 2614 17014854
SGTC_2183 6420625 130.508 µM -0.10084226151556 0.454810073239591 no 1856 0.459837838987855 2579 2897619
SGTC_897 1000-0139 31.4 µM -0.101070663763946 0.454718517818188 no 1857 0.459747182846511 2572 6151020
SGTC_2989 9073649 71.4286 µM -0.101869478921718 0.454398330382492 no 1858 0.459430138096915 2562 21367202
SGTC_1948 st076329 66.6 µM -0.102168784233315 0.45427836807015 no 1859 0.459311352320462 2567 24208413
SGTC_1323 1348-1351 11.2 µM -0.102431267890033 0.454173167400687 no 1860 0.459207183002121 2598 6989654
SGTC_1628 st004252 77.7 µM -0.10259875707163 0.454106041190409 no 1861 0.459140714674127 2684 692968
SGTC_2769 toremifene 3.73 µM -0.102824922333168 0.454015400897729 no 1862 0.45905096247037 2712 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1877 wortmannin 25 µM -0.102920306870884 0.453977174337076 no 1863 0.459013110366382 2633 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1827 berberine 7.24 µM -0.10484230177422 0.453207001877758 no 1864 0.458250471516873 2602 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1290 0986-0249 10.2 µM -0.10631332531117 0.452617659201913 no 1865 0.457666879719459 2622 53329
SGTC_688 0527-0193 473 µM -0.108293146150675 0.451824639798357 no 1866 0.456881579611659 2651 4007154
SGTC_1814 st052110 31.539 µM -0.109106870267381 0.451498757261037 no 1867 0.456558862869494 2632 674163
SGTC_1569 carminic acid 40.6 µM -0.109332459754882 0.451408418321511 no 1868 0.456469400872754 2631 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2838 9002687 71.43 µM -0.110380867179894 0.450988609093885 no 1869 0.456053663089855 2588 6457060
SGTC_39 0986-0283 58.349 µM -0.110754266885727 0.450839103487336 no 1870 0.455905605945327 2659 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2362 9071156 126 µM -0.11126120108568 0.450636143135301 no 1871 0.45570461068853 2724 653133
SGTC_1813 st051246 8.6015 µM -0.112052772994033 0.450319248718419 no 1872 0.455390781602547 2624 5291959
SGTC_774 k060-0086 136 µM -0.11272547387685 0.450049967491568 no 1873 0.455124102367844 2602 5911235
SGTC_3274 9138298 49.47 µM -0.113375758658918 0.449789681256681 no 1874 0.454866328782954 2589 17015756
SGTC_1547 harmine 94.2 µM -0.113884364214881 0.449586119304292 no 1875 0.454664730234168 2613 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2213 7173844 200 µM -0.114355361290735 0.449397621427038 no 1876 0.454478049160629 2620 892728
SGTC_794 k038-0031 316 µM -0.115023340428038 0.449130308892321 no 1877 0.454213310920078 2596 6624242
SGTC_2420 aureobasidin a 50 nM -0.115763999732581 0.448833938135292 no 1878 0.453919791343841 2902 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2018 5133068 143 µM -0.115798478745886 0.448820142241441 no 1879 0.453906128095191 2609 785362
SGTC_2216 7189485 200 µM -0.116584887396765 0.448505497801394 no 1880 0.453594507079196 2645 731273
SGTC_3291 9121177 71.43 µM -0.116708230533131 0.44845615077902 no 1881 0.453545633915109 2644 17015612
SGTC_1800 st050079 29.0735 µM -0.118620583811447 0.447691160526485 no 1882 0.452787978484161 2670 3645560
SGTC_289 k017-0060 526 µM -0.118969773524575 0.447551496624058 no 1883 0.452649651452027 2632 5512909
SGTC_2168 5727979 200 µM -0.119073487785377 0.447510015730552 no 1884 0.452608567482168 2594 695210
SGTC_1232 0279-0259 161 µM -0.119561717218788 0.447314754323587 no 1885 0.452415173675772 2624 1560000
SGTC_2511 berberine 10.47 µM -0.119754439335415 0.447237680976037 no 1886 0.452338837131509 2655 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1680 diphenhydramine 100 µM -0.120211334781087 0.447054967508607 no 1887 0.452157869516571 2698 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_525 k781-2675 26.7 µM -0.121282450510725 0.44662667015131 no 1888 0.451733659932225 2616 3651118 YDL195W SEC31
SGTC_3237 9133362 49.47 µM -0.121633022361671 0.446486503653994 no 1889 0.451594829794941 2634 43845137
SGTC_954 1189-0853 2.85 µM -0.121920872143459 0.44637141984594 no 1890 0.451480842681273 2584 2828194
SGTC_1968 st069590 43.6 µM -0.122602767935335 0.446098812479123 no 1891 0.451210831243635 2705 6384066
SGTC_483 fpl-64176 144 µM -0.123460889691752 0.44575578995527 no 1892 0.450871071402715 2631 3423
SGTC_1740 st038286 13.222 µM -0.123523619679174 0.445730716083619 no 1893 0.450846235857551 2784 716786
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.123631180511982 0.445687723331104 no 1894 0.450803651697535 2685 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1038 k292-0204 154 µM -0.123979310464566 0.445548577944577 no 1895 0.450665828259776 2605 4454212
SGTC_666 0272-0154 136 µM -0.125310338001726 0.445016636470113 no 1896 0.450138934077741 2662 6870312
SGTC_1177 0983-0204 23.6 µM -0.125990823700153 0.444744720424004 no 1897 0.449869594159311 2714 766818
SGTC_3260 9137109 49.47 µM -0.126443239122396 0.444563953617464 no 1898 0.449690538460785 2606 17478346
SGTC_2753 fluvastatin 17.09 µM -0.128478862109218 0.443750744625091 no 1899 0.448885012586362 2699 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2549 cedrol 20.94 µM -0.129107805908672 0.443499536220944 no 1900 0.448636172742343 2656 6708665 A sedative which affects the nervous system.
SGTC_73 0327-0325 16.231 µM -0.130203069021968 0.443062128019342 no 1901 0.448202883261797 2813 53298
SGTC_2317 5986382 200 µM -0.131895289988114 0.442386453181459 no 1902 0.447533557063554 2706 877883
SGTC_1975 st070967 30.8 µM -0.131933846028947 0.44237106035988 no 1903 0.447518308679572 2676 261391
SGTC_1966 st070145 16.1 µM -0.132309454536987 0.442221109821134 no 1904 0.447369764741355 2622 3748532
SGTC_218 alverine citrate 93.75 µM -0.13240318169944 0.442183693325599 no 1905 0.447332699101032 2738 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2029 5175081 200 µM -0.132901693685597 0.441984692759396 no 1906 0.447135563710243 2635 1380876
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.13319293528218 0.441868439051851 no 1907 0.447020398947684 2650 140250 A respiratory chain inhibitor.
SGTC_1905 st060207 84.5 µM -0.133713577932491 0.441660628753721 no 1908 0.446814533974405 2635 1948547
SGTC_1437 4092-1038 11.6 µM -0.134292537091901 0.44142956075167 no 1909 0.446585627163368 2660 3977136
SGTC_1481 3346-2004 36 µM -0.134996962327525 0.441148444956867 no 1910 0.446307138028974 2654 2770522
SGTC_325 2810-4341 181 µM -0.135294667264987 0.441029648407399 no 1911 0.446189450609664 2758 774970
SGTC_2516 gossypol 71.55 µM -0.136571409189606 0.440520236021603 no 1912 0.445684788434552 2769 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2132 5317594 122.667 µM -0.137302084965062 0.440228744987982 no 1913 0.445396011240959 2658 794577
SGTC_3337 9144342 33.5465 µM -0.137330455668814 0.440217427616503 no 1914 0.445384799173584 2749 17682949
SGTC_1524 corynanthine 62.1 µM -0.137342368768997 0.440212675370371 no 1915 0.445380091144005 2847 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_170 4197-0004 226 µM -0.139909640108231 0.439188769065145 no 1916 0.44436569225238 2785 218692
SGTC_3275 9138069 49.47 µM -0.141074912912497 0.438724156436151 no 1917 0.443905381008968 2734 17617007
SGTC_2234 tolnaftate 200 µM -0.141098434776938 0.438714778765288 no 1918 0.443896090074538 2670 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2031 5180455 200 µM -0.141149666544858 0.438694353859874 no 1919 0.443875854072955 2654 29949
SGTC_2882 9058044 58.44 µM -0.141664051656963 0.438489289626355 no 1920 0.443672685562321 2735 18076804
SGTC_1560 lithocholic acid 53.1 µM -0.142167260534348 0.438288696876722 no 1921 0.443473945693683 2653 9903 A bile acid which acts as a detergent.
SGTC_752 1896-0090 130 µM -0.142700777108678 0.438076039969972 no 1922 0.443263251477966 2657 772567
SGTC_359 0081-0058 15.9 µM -0.143380099205442 0.43780529163386 no 1923 0.442994999555312 3007 3494159
SGTC_2435 5706476 10.6 µM -0.143572271129585 0.43772870551403 no 1924 0.442919119098364 2742 5725375
SGTC_1953 st076800 12.1 µM -0.144461236248603 0.437374457370485 no 1925 0.442568132156389 2694 297591
SGTC_576 1073-0113 22.7 µM -0.145619406970902 0.436913007485971 no 1926 0.442110923374149 2688 5439563
SGTC_2865 9030313 51.95 µM -0.146359905961654 0.436618015459475 no 1927 0.441818638411662 2662 42562754
SGTC_283 0987-0079 11.7 µM -0.146764325998371 0.436456921823298 no 1928 0.44165902171968 2733 411556
SGTC_1253 0550-0034 176 µM -0.147204131558653 0.436281744946675 no 1929 0.44148544980663 2767 5969915
SGTC_1794 st048918 76.9 µM -0.148459873449573 0.435781645218157 no 1930 0.440989925663634 2626 672303
SGTC_3116 9124943 49.47 µM -0.149377265010374 0.435416358503264 no 1931 0.440627975169674 2682 41905195 YPL160W CDC60
SGTC_299 1273-0059 1.44 µM -0.151386375923813 0.43461656417899 no 1932 0.439835468019494 2759 2848077
SGTC_1529 apigenin 74 µM -0.152380519571269 0.434220910513596 no 1933 0.439443410388639 2877 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1168 k815-0004 80.5 µM -0.152633936387266 0.434120065095509 no 1934 0.439343480596176 2665 642433
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.153798825545485 0.433656560996019 no 1935 0.438884179949083 2676 17037758
SGTC_1144 3486-0183 12.5 µM -0.153906283178395 0.433613808678323 no 1936 0.438841814937651 2705 6744069
SGTC_469 w7 172 µM -0.154050822152438 0.433556304671149 no 1937 0.43878483176792 2679 45115570 A P450 inhibitor.
SGTC_2158 5657123 3.6195 µM -0.155709701238874 0.432896430079048 no 1938 0.438130924982549 2658 2858827
SGTC_2430 5571206 200 µM -0.156719463974441 0.432494854680684 no 1939 0.437732973301149 2778 1731771
SGTC_2995 9067767 71.4286 µM -0.157295909435141 0.432265637689062 no 1940 0.437505821964296 2772 11673567
SGTC_2645 abamectin 100 µM -0.157560740444967 0.43216033828302 no 1941 0.43740147082526 2735 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_413 propylparaben 100 µM -0.16105193639718 0.430772657810523 no 1942 0.436026247585222 2674 7175 A pharmaceutical preservative.
SGTC_1406 3909-7906 11.9 µM -0.161654727254585 0.430533146526979 no 1943 0.435788878962494 2727 X1406
SGTC_51 1013-0126 23.419 µM -0.162458511925637 0.430213812674555 no 1944 0.435472398446819 2761 1627850
SGTC_1378 2093-0007 380 nM -0.16267098164363 0.430129408663324 no 1945 0.435388747956316 2795 3618014
SGTC_1412 3909-8563 178 µM -0.162745625112161 0.430099757157028 no 1946 0.435359361100415 2767 23767530
SGTC_2950 9072895 21.46 µM -0.163115670279108 0.429952765570838 no 1947 0.43521368096947 2789 17332245
SGTC_824 1304-0008 100 µM -0.164823170881948 0.429274627885094 no 1948 0.43454158287241 2725 768245
SGTC_1272 0839-0021 27 µM -0.165043164433127 0.429187272086567 no 1949 0.434455003791796 2784 5027250
SGTC_1855 st056195 39.6 µM -0.165488292205747 0.429010529826158 no 1950 0.434279832124563 2876 4028379
SGTC_1276 0871-0068 94.2 µM -0.165922629377172 0.428838085796528 no 1951 0.43410891933319 2799 3414906
SGTC_1558 st069300 45.6 µM -0.166083797175778 0.428774101117155 no 1952 0.434045502522321 2727 24208000
SGTC_3227 9130768 49.47 µM -0.166401054428114 0.428648153365524 no 1953 0.433920672104724 2715 17720899
SGTC_852 0418-0143 439 µM -0.167038811435612 0.428394992620083 no 1954 0.433669755400818 2768 5369229
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.167113847351352 0.428365208683702 no 1955 0.433640235309531 2936 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1345 1488-0192 31.4 µM -0.16778967935797 0.428096969720348 no 1956 0.43337437103405 2767 658348
SGTC_984 1492-0255 2.91 µM -0.167839400029718 0.428077236804987 no 1957 0.433354812702068 2840 1585198
SGTC_3141 9094609 49.47 µM -0.168558423293352 0.427791894235129 no 1958 0.433071992965436 2693 25236309 YDL196W YDL196W
SGTC_2546 rhodinyl acetate 100 µM -0.169128141302078 0.427565829884621 no 1959 0.43284792510742 2711 6708682
SGTC_1490 4089-0339 670 nM -0.16913275855652 0.427563997853115 no 1960 0.432846109247457 2708 742542
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.169685681592015 0.427344620679355 no 1961 0.432628667599775 2833 23847180
SGTC_2932 9016711 44.54 µM -0.17160441846296 0.426583519274278 no 1962 0.431874266778381 2786 7117328
SGTC_3053 9095903 49.47 µM -0.171848707564551 0.426486637173329 no 1963 0.431778235992659 2716 17174018
SGTC_780 0109-0199 192 µM -0.171893341006005 0.426468936569742 no 1964 0.431760690887044 2905 610414
SGTC_2797 7859098 81.82 µM -0.1741278627941 0.425582966296392 no 1965 0.430882488171856 2749 972681
SGTC_2563 tomatine 8.54 µM -0.174561214998677 0.425411188908945 no 1966 0.430712213261111 2701 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2890 9046729 58.44 µM -0.175559834982563 0.425015397798228 no 1967 0.430319879604499 2762 903329
SGTC_465 cgp-37157 41 µM -0.175783236970908 0.424926865416804 no 1968 0.430232119763212 2798 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_2953 9074162 66.49 µM -0.17951351477777 0.423449149633718 no 1969 0.428767253218572 2815 16451992
SGTC_2872 9044037 25.97 µM -0.181057358941426 0.422837883380166 no 1970 0.428161276997249 2708 6465195
SGTC_2304 7443016 91.4 µM -0.181145370380147 0.422803041907388 no 1971 0.428126736605801 2685 939854
SGTC_2490 carminic acid 95.39 µM -0.182926291161052 0.4220981511205 no 1972 0.427427926793813 2687 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2593 nobiletin 86.24 µM -0.183174312290176 0.422000003770822 no 1973 0.427330624584176 2816 72344 An anti-infammatory.
SGTC_1708 st033234 31.827 µM -0.183786369716088 0.421757820088356 no 1974 0.427090524694138 2846 674664
SGTC_509 pifithrin 175 µM -0.184179232094389 0.42160238480736 no 1975 0.426936425580081 2734 4817 A p53 inhibitor.
SGTC_592 k241-0073 46.5 µM -0.184645186042458 0.421418046816794 no 1976 0.426753670968627 2824 4230158
SGTC_3102 9121669 49.47 µM -0.186241564894751 0.420786627512441 no 1977 0.426127665023869 2764 41905072
SGTC_1646 st011709 75.6 µM -0.186611763742071 0.42064023097411 no 1978 0.42598252132227 2778 5757843
SGTC_2536 dehydroabietamide 32.04 µM -0.187057714466005 0.420463892644301 no 1979 0.425807690931143 2882 3983547
SGTC_1806 st050005 60.3 µM -0.187445322673567 0.420310637140998 no 1980 0.425655744968261 2734 5194765
SGTC_3173 9105693 49.47 µM -0.187635281272782 0.420235534263878 no 1981 0.425581283489171 2889 17096658
SGTC_1307 1187-1599 12.2 µM -0.188811409036485 0.419770599913515 no 1982 0.425120314781003 2742 1538471
SGTC_1931 st074438 57.1 µM -0.189100402979616 0.419656375004245 no 1983 0.425007062826095 2682 2787313
SGTC_2268 7933382 153.85 µM -0.189863253270101 0.419354890827661 no 1984 0.424708144146389 2707 935025 YOR257W CDC31
SGTC_759 3486-0358 89.3 µM -0.191107859797417 0.418863114657047 no 1985 0.424220544950931 2782 875103
SGTC_731 3966-0296 387 µM -0.191624742889165 0.418658918011282 no 1986 0.424018079826595 2755 660956
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.191727647994547 0.418618267569225 no 1987 0.423977773887063 2743 688664
SGTC_2300 7976697 71.57 µM -0.192686966533275 0.41823935134393 no 1988 0.423602065685552 2768 2236109
SGTC_1876 myriocin 605 nM -0.193096642068064 0.418077558838855 no 1989 0.423441641205301 2866 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_148 3253-0744 288.01 µM -0.193667327332787 0.417852202129132 no 1990 0.423218188224479 2721 6893655
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.194003845795041 0.417719327694832 no 1991 0.423086435303465 2905 5377381
SGTC_2079 5212404 121 µM -0.196912079132556 0.416571403652159 no 1992 0.421948170481777 2835 758462
SGTC_1843 st055809 45.5 µM -0.197682788641537 0.416267311651875 no 1993 0.421646628323417 2890 16413835
SGTC_2896 9052656 71.43 µM -0.19914614885895 0.415690064670627 no 1994 0.421074211281821 2827 6469436
SGTC_405 ebelactone b 50 µM -0.200236063208407 0.415260247782208 no 1995 0.420647981947874 2763 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_3171 9103192 49.47 µM -0.200320573742977 0.415226924571397 no 1996 0.420614936561536 2787 13018434
SGTC_630 4356-0227 183 µM -0.200608998114002 0.41511320102229 no 1997 0.420502160814843 2773 779312
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.200886017984313 0.415003980877256 no 1998 0.420393850442854 2754 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1471 k673-0312 37 µM -0.200988057174362 0.41496375171733 no 1999 0.420353956257791 2778 24099884
SGTC_456 gingerol 170 µM -0.202404273381138 0.414405497823896 no 2000 0.419800343933534 2943 442793 A herb.
SGTC_219 mitoxanthrone 164.414 µM -0.202698012656639 0.414289731253875 no 2001 0.419685538302163 2831 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_191 3914-0123 66.505 µM -0.203613622178663 0.413928925138916 no 2002 0.419327723593796 2766 3144412
SGTC_2114 5491910 81.25 µM -0.20382759839298 0.413844615892663 no 2003 0.419244112577755 2886 2849228
SGTC_2937 9044753 11.33 µM -0.204655572622587 0.413518421361754 no 2004 0.418920616769287 2747 6465530 YGL099W LSG1
SGTC_1889 st059080 5.18 µM -0.2060955689571 0.412951252583184 no 2005 0.418358129968469 2791 176925 Isolated from Daphnopsis sellowiana.
SGTC_914 3820-6779 408 µM -0.206352523312252 0.41285006549675 no 2006 0.41825777679003 2745 2893481
SGTC_1136 pergolide 1.05886 µM -0.206354749059066 0.412849189036268 no 2007 0.418256907550836 2791 47811 A dopamine receptor agonist.
SGTC_3068 9116768 49.47 µM -0.207157993092198 0.412532913874329 no 2008 0.417943236159932 2871 41904888
SGTC_1687 st020778 55.3625 µM -0.208222278030038 0.412113942056736 no 2009 0.417527707221882 2803 4259299
SGTC_1789 tunicamycin 25 nM -0.208437462305844 0.412029243677349 no 2010 0.417443703966272 2887 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1126 isoteolin 1.0172 µM -0.208731852201351 0.411913375924263 no 2011 0.417328786665303 2790 133323
SGTC_2163 5671233 125 µM -0.209125425582781 0.411758482933544 no 2012 0.417175163379891 2934 701023
SGTC_2879 9041815 71.43 µM -0.209549626022749 0.411591551889831 no 2013 0.417009599609684 2776 4942971
SGTC_735 3076-0345 636 µM -0.210483237492955 0.411224214196756 no 2014 0.416645266586522 2923 2888990
SGTC_459 nigericin 15.3 µM -0.211120356197139 0.410973578859245 no 2015 0.416396678131291 2891 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1006 4099-6547 255 µM -0.211324211242942 0.410893392244356 no 2016 0.416317145831958 2879 3146833
SGTC_2259 7964009 200 µM -0.211631235892249 0.410772630776226 no 2017 0.416197369262685 2936 313134
SGTC_2366 9070441 60.58 µM -0.211712472863552 0.410740679394879 no 2018 0.41616567836708 2797 6837235
SGTC_557 1315-0110 16.2 µM -0.211826043144125 0.410696011965387 no 2019 0.416121375020652 2784 6833801
SGTC_3066 9117245 49.47 µM -0.211910606405121 0.410662753809708 no 2020 0.41608838789749 2826 17176980
SGTC_730 1436-0052 41.2 µM -0.212792105255582 0.410316104593727 no 2021 0.415744560911042 2773 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1722 st034304 3.6505 µM -0.213450720802838 0.410057149896714 no 2022 0.415487711219141 2816 4036148 YLR033W RSC58
SGTC_9 0092-0002 10.449 µM -0.214850783133864 0.409506803318504 no 2023 0.41494182904545 2820 759368
SGTC_2848 9016370 25.97 µM -0.215118464052483 0.409401601644202 no 2024 0.414837479326647 2827 7894410
SGTC_1818 st052136 56.3 µM -0.216730821955413 0.408768064730281 no 2025 0.414209063205474 2858 674169
SGTC_3236 9132701 49.47 µM -0.216829427098705 0.408729327947709 no 2026 0.414170638982064 2833 24282524
SGTC_2747 doxorubicin 7.63 µM -0.217462445073589 0.408480669677959 no 2027 0.413923985587518 2778 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1275 0867-0008 21.1 µM -0.219565578163585 0.407654794798816 no 2028 0.413104750926552 2789 3422836
SGTC_1476 4112-3294 3.34 µM -0.220783886245303 0.407176567385112 no 2029 0.4126303554519 2911 704369
SGTC_917 harmaline 728.087 nM -0.22098228484105 0.407098702259332 no 2030 0.412553113331179 2913 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2399 5884133 200 µM -0.222264382378155 0.406595608491787 no 2031 0.412054038689425 2817 722445
SGTC_1073 triclabendazole 3.09 µM -0.222597042977371 0.406465097961999 no 2032 0.411924569038214 2870 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1025 k007-0731 70 µM -0.223779145795367 0.406001415545614 no 2033 0.411464578863757 2798 6256118
SGTC_716 1683-5115 658 µM -0.223839383097669 0.405977790856493 no 2034 0.411441142051182 2768 723597
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.223891334243912 0.40595741622036 no 2035 0.411420929426389 2903 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1993 st073995 70.8 µM -0.224883170004033 0.405568478669692 no 2036 0.41103508118405 2828 3098394
SGTC_1267 0828-0272 9.49 µM -0.226169354722652 0.405064254257133 no 2037 0.410534852237628 2945 745334
SGTC_2421 5690543 90.72 µM -0.226632709491979 0.404882643337185 no 2038 0.410354677752036 2889 3397993
SGTC_2544 sphondin 68.51 µM -0.228194908172053 0.404270494052883 no 2039 0.409747359857373 3036 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1084 voriconazole 435 nM -0.230334035991755 0.403432654789579 no 2040 0.408916107314443 2877 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_977 1348-1378 135 µM -0.232038771357626 0.402765272459248 no 2041 0.408253950145821 2801 X977
SGTC_1456 k015-0012 13 µM -0.232595966368795 0.402547198980606 no 2042 0.408037579895288 2844 2989616
SGTC_420 mitomycin C 81.9 mM -0.233362705363736 0.402247164324754 no 2043 0.407739885271653 2828 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_926 2268-1401 59.4 µM -0.233481278635005 0.402200770242389 no 2044 0.407693852680658 2796 2931578
SGTC_166 k072-0058 166.424 µM -0.23355544483652 0.402171751984041 no 2045 0.407665060478411 2874 5846229
SGTC_1878 temozolomide 1 mM -0.23388908623486 0.402041218164585 no 2046 0.407535543086547 2873 5394 DNA alkylating agent.
SGTC_2724 maprotiline 69.64 µM -0.234040460194427 0.401981998237381 no 2047 0.407476784045169 2855 4011 A tricyclic antidepressant.
SGTC_1355 1499-0035 1.68 µM -0.234062408410706 0.401973411928984 no 2048 0.407468264548155 2811 1548538
SGTC_29 0299-0004 12.984 µM -0.234129876853075 0.401947018059726 no 2049 0.407442076033762 2810 16871 A napthoquinone isolated from Swertia calycina.
SGTC_705 1124-0212 310 µM -0.234879718479713 0.401653707758639 no 2050 0.407151045783564 2927 9554485
SGTC_1718 roemerine 11.9335 µM -0.235918628785501 0.401247416059308 no 2051 0.406747906266278 2953 235224 An aporphine alkaloid with mutagenic activity.
SGTC_868 0527-0199 213 µM -0.238183752329287 0.400361953879482 no 2052 0.405869289149965 2860 2849450
SGTC_2735 sertaconazole 140 nM -0.238235671249956 0.400341664175116 no 2053 0.405849155897147 2806 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3125 9127534 49.47 µM -0.238391532710918 0.400280755761903 no 2054 0.405788717034381 2802 1639235
SGTC_2492 derrusnin 100 µM -0.240993381192476 0.399264350117485 no 2055 0.404780123206815 2767 1715307 Part of coumarin class of compounds.
SGTC_3099 9120367 49.47 µM -0.243609446199077 0.398243078854187 no 2056 0.403766655834063 2822 24824940
SGTC_365 0121-0052 13.6 µM -0.24462992129986 0.397844889666814 no 2057 0.403371496998704 2981 3101739
SGTC_464 bw-b 70c 158 µM -0.24487739252084 0.397748342457249 no 2058 0.403275683499579 2964 5353454
SGTC_12 0849-0099 9.267 µM -0.24636102642685 0.397169656302219 no 2059 0.402701386500897 2867 6071388
SGTC_2007 4011539 71.82 µM -0.246709142033186 0.39703390777448 no 2060 0.402566665454872 2832 45595301
SGTC_356 1634-0012 32.5 µM -0.246977458449205 0.396929285647021 no 2061 0.402462834660456 2926 735457
SGTC_695 3505-6186 243 µM -0.24907047738787 0.396113429389623 no 2062 0.401653132787254 2964 1819379
SGTC_3300 9124615 50.48 µM -0.250371063441801 0.3956066913938 no 2063 0.401150202572856 3030 24824903
SGTC_2125 5246583 200 µM -0.251233042845055 0.395270941710447 no 2064 0.400816969561496 2953 835267
SGTC_2731 amoxapine 43.43 µM -0.251645738631154 0.395110220035035 no 2065 0.400657450838214 2862 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2990 9074105 71.4286 µM -0.251756735051845 0.395066996248595 no 2066 0.400614550373226 2896 6502001
SGTC_337 1315-0038 354 µM -0.252004558311696 0.394970494557143 no 2067 0.400518770232467 2866 1626437
SGTC_431 k089-0097 107 µM -0.253430199663046 0.394415479065438 no 2068 0.399967896615102 2970 5499420
SGTC_2004 4023728 41.89 µM -0.253597810369669 0.394350240708141 no 2069 0.399903144209092 3001 360084 YDR527W RBA50
SGTC_2916 7875993 68.79 µM -0.253957478802457 0.394210258595569 no 2070 0.39976420416504 2877 1299250
SGTC_1058 3448-5425 97.3 µM -0.254891681711444 0.393846732885498 no 2071 0.399403380577683 2803 7279705
SGTC_3115 9123671 49.47 µM -0.255061538851156 0.393780646425314 no 2072 0.399337784712784 2824 3286988
SGTC_2103 5378138 10 µM -0.257055864019913 0.393004941951825 no 2073 0.398567824152231 2868 244142
SGTC_650 1328-0195 38 µM -0.258369606567886 0.392494185893326 no 2074 0.398060835448601 2912 2780821
SGTC_2746 daunorubicin 9.88 µM -0.259424072580919 0.392084365082835 no 2075 0.397654029044861 2862 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_937 3122-0005 46.7 µM -0.259741042465413 0.391961197332302 no 2076 0.397531765773876 3023 759535
SGTC_1655 st012546 55.1 µM -0.260300411048666 0.391743865023708 no 2077 0.397316027779342 2966 720985 YLR208W SEC13
SGTC_1447 4239-0816 81.9 µM -0.260341329799095 0.391727968125765 no 2078 0.397300247415179 2869 1341554
SGTC_3311 9131146 2.8755 µM -0.26044786038913 0.391686581934887 no 2079 0.39725916455661 2904 4900406 YPR165W RHO1
SGTC_2884 9058502 51.95 µM -0.263333028879383 0.390566187143784 no 2080 0.396146952204562 2979 6471554
SGTC_392 N-ethylmaleimide 8.33 µM -0.263992917634746 0.390310060415574 no 2081 0.395892688067466 2916 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1337 1486-1011 40.3 µM -0.26442172675494 0.390143649572834 no 2082 0.395727485800465 2872 X1337
SGTC_506 n9-isopropylolomoucine 153 µM -0.264688847039676 0.390039996578271 no 2083 0.395624584963591 3024 6610355
SGTC_547 1120-0019 610 nM -0.267276870912337 0.389036149135247 no 2084 0.394627996762343 2852 3676939
SGTC_2518 prenyletin 46.28 µM -0.267282751399879 0.389033869041404 no 2085 0.394625733104789 2984 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2093 5331342 194.4 µM -0.268886383953457 0.388412221171755 no 2086 0.39400855763182 3021 33839
SGTC_3270 9137563 49.47 µM -0.269399152926936 0.388213506583412 no 2087 0.393811268970652 2986 17015724
SGTC_3161 9100388 49.47 µM -0.270050254295695 0.387961225882948 no 2088 0.393560795981992 2889 25236368
SGTC_2162 5663267 200 µM -0.271706868358914 0.387319554976134 no 2089 0.392923709863259 3037 6456493
SGTC_766 1391-0721 126 µM -0.272326424434581 0.387079655839788 no 2090 0.392685519990903 3053 1020919 YIL115C NUP159
SGTC_1951 sophoraflavanone G 9.2 µM -0.272446951576359 0.387032991372236 no 2091 0.392639187698278 2876 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_3038 9091290 49.47 µM -0.273092137409539 0.386783222690659 no 2092 0.392391195266842 3047 25236843
SGTC_112 phenothiazine 287.218 µM -0.274710685538831 0.386156845996245 no 2093 0.391769260516577 3021 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1449 4112-4002 201 µM -0.277941731173193 0.384907322724662 no 2094 0.390528544322235 2926 2059539
SGTC_3133 9127736 49.47 µM -0.2783616424272 0.384745020336834 no 2095 0.390367380614186 3020 27243420
SGTC_727 3032-0951 202 µM -0.279194369195773 0.384423217940761 no 2096 0.390047832315711 2957 3652836
SGTC_925 2064-1272 59.6 µM -0.279731589577714 0.384215654507168 no 2097 0.389841720239055 2911 6815817
SGTC_2684 capsaicin 100 µM -0.280206820503583 0.384032069334137 no 2098 0.389659417095415 2985 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_462 ag-879 158 µM -0.2822568840642 0.383240413522722 no 2099 0.388873271740702 3017 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2374 9071832 200 µM -0.282564225913105 0.383121771830624 no 2100 0.388755453365577 2877 17381698
SGTC_1381 2324-0066 62.1 µM -0.282866965418778 0.383004917476092 no 2101 0.388639409284553 3023 10885928
SGTC_2081 5214970 32.255 µM -0.286654694522762 0.381543795878175 no 2102 0.387188365410084 3020 2063512
SGTC_1783 st039459 87.517 µM -0.287932608116049 0.381051218405812 no 2103 0.386699162865613 3122 729761
SGTC_2295 7971645 200 µM -0.288291826629422 0.380912790692882 no 2104 0.386561681551208 2971 2978226 YKL099C UTP11
SGTC_1746 st038117 42 µM -0.288745036385439 0.380738164452458 no 2105 0.386388247906989 3015 2898218
SGTC_1707 st032323 6.317 µM -0.290607376734554 0.380020841510485 no 2106 0.385675808824611 2940 3132057 YMR211W DML1
SGTC_2433 5607874 27.82 µM -0.290684893486757 0.379990993088366 no 2107 0.385646163099132 2911 2252428
SGTC_1694 st024011 44.9 µM -0.29261650867682 0.379247441060826 no 2108 0.384907646870556 2986 2787533
SGTC_578 3460-0051 92 µM -0.293261945755206 0.378999087206783 no 2109 0.384660969205718 3022 2876744
SGTC_2754 granisetron 64.02 µM -0.293608909602584 0.378865601706736 no 2110 0.38452838341999 3063 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_815 1582-0027 36.9 µM -0.293727625872845 0.378819931962964 no 2111 0.384483021304179 3014 3128206
SGTC_1786 berberine 21.6 µM -0.293851984471172 0.378772093449308 no 2112 0.384435504921246 2915 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1665 st014639 11.4 µM -0.294239069320706 0.378623200767906 no 2113 0.384287614146388 2952 981133 YIL048W NEO1
SGTC_2647 atorvastatin 60.16 µM -0.294367096379555 0.378573958959814 no 2114 0.38423870345782 2985 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1885 st057546 99.9 µM -0.29645797746494 0.377770043160841 no 2115 0.383440177204728 3088 702008
SGTC_418 lividomycin a 100 µM -0.296680615511575 0.377684472921264 no 2116 0.38335517883007 3047 72394 An antibiotic.
SGTC_421 streptovitacin 30 mM -0.297955398359167 0.377194629805775 no 2117 0.382868602622491 3111 91467 include heat shock
SGTC_748 act1.228 77.9 µM -0.299229760221831 0.376705145886596 no 2118 0.38238237179084 2925 4421505 YNR035C ARC35
SGTC_3008 9078912 71.4286 µM -0.29935233276627 0.376658076058634 no 2119 0.382335614184022 2958 16648731
SGTC_2589 lobaric acid 100 µM -0.299973106578445 0.37641971710553 no 2120 0.38209883467572 2961 73157 A novel microtubule depolymerizer.
SGTC_2140 5586273 200 µM -0.301524392230427 0.375824275042785 no 2121 0.381507326331937 2933 854421
SGTC_1249 0481-0015 10.2 µM -0.301784021848951 0.375724648218338 no 2122 0.381408356022035 2896 4227577
SGTC_588 3970-1144 52.9 µM -0.301923811178911 0.375671010746681 no 2123 0.381355071810103 3054 1888707
SGTC_3061 glucosamine 200 µM -0.302118551959144 0.375596292288603 no 2124 0.381280845222434 3037 91431 and experimental redox chemotherapeutic
SGTC_11 0438-0307 1.3 µM -0.302196564269485 0.375566361707679 no 2125 0.381251111598908 3023 4011476
SGTC_3292 9120825 59.784 µM -0.302234800210646 0.375551692194715 no 2126 0.381236538602591 3098 24824900
SGTC_2603 homopterocarpin 100 µM -0.302437813808735 0.375473807480214 no 2127 0.381159166150088 3057 101795 A weak amylase inhibitor.
SGTC_1909 st060837 51.5 µM -0.302773713953408 0.375344952939314 no 2128 0.381031158469633 2980 678937
SGTC_3354 9151612 71.43 µM -0.303173990897981 0.375191420997033 no 2129 0.38087863453196 3071 27261949
SGTC_2423 st077119 87.2 µM -0.303303673001974 0.375141683811967 no 2130 0.380829223650453 2934 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1435 4092-0789 56.7 µM -0.303972632047632 0.374885149869278 no 2131 0.380574370824087 3041 2248285
SGTC_2524 avocatin b 10.57 µM -0.30453496078396 0.374669549572992 no 2132 0.380360180949194 3044 6710748
SGTC_2566 crystal violet carbinol 226 nM -0.305055972030426 0.374469825614549 no 2133 0.38016176155438 3100 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2070 5230947 200 µM -0.305225641519165 0.374404791939826 no 2134 0.380097152253913 3040 2835538
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.306173761874299 0.374041446804151 no 2135 0.379736174356621 3191 6710655
SGTC_1277 0873-0036 22 µM -0.306726988736574 0.37382948710505 no 2136 0.379525592657835 3015 5965735
SGTC_1945 st075991 56.6 µM -0.307204335848471 0.373646630131115 no 2137 0.379343922736139 2991 1084980
SGTC_699 0375-0592 111 µM -0.308482412312357 0.373157178527239 no 2138 0.378857640543956 3081 762578
SGTC_1417 3966-0327 90.4 µM -0.309860739964334 0.372629564109711 no 2139 0.378333429656499 2999 651118
SGTC_1622 st003707 19.4 µM -0.311001741425208 0.372192977228374 no 2140 0.377899648885563 3083 10140899
SGTC_3070 9117005 49.47 µM -0.311068933394334 0.372167272356938 no 2141 0.377874108940249 2993 8779016
SGTC_2571 chrysanthemic acid 100 µM -0.311579281425087 0.371972052886035 no 2142 0.377680140975884 3000 2743 An insecticide.
SGTC_2772 vinpocetine 57.06 µM -0.31331014742172 0.371310203489386 no 2143 0.377022520722177 3161 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1165 k072-0275 30.3 µM -0.313584799178285 0.371205216931295 no 2144 0.376918203052457 3074 6153523 YGL055W OLE1
SGTC_387 norethindrone acetate 66.7 µM -0.313841829134988 0.371106975046266 no 2145 0.376820586596656 2993 541197
SGTC_2919 7978188 46.38 µM -0.313885233908805 0.371090385720132 no 2146 0.376804102835246 3129 2980291
SGTC_3172 9105863 49.47 µM -0.314196824852622 0.370971302540477 no 2147 0.37668577703615 3006 2348785
SGTC_1111 tnp00062 510.699 nM -0.314254507796656 0.370949258747793 no 2148 0.376663873368083 3111 676306
SGTC_2815 7968870 71.43 µM -0.317739372008347 0.369618290549981 no 2149 0.375341321560308 2961 2977326 YHR190W ERG9
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.317901598661134 0.369556369500727 no 2150 0.37527978995292 2996 6708561
SGTC_2597 laccaic acid a 100 µM -0.318534463382749 0.369314840762771 no 2151 0.375039778466198 3097 5491415 A textile dye.
SGTC_2131 toluylene red 5.2905 µM -0.318918743891063 0.369168207745923 no 2152 0.374894065177687 2987 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_738 1315-0003 72.4 µM -0.320143915597164 0.368700836266081 no 2153 0.374429618128393 3126 6251474
SGTC_994 3910-0338 138 µM -0.320711728473225 0.368484296057552 no 2154 0.374214429199551 3155 3479481
SGTC_124 0136-0217 7.121 µM -0.32126979210352 0.368271514495178 no 2155 0.374002973205745 3127 3976905
SGTC_2687 chenodiol 100 µM -0.321849397343847 0.368050562197067 no 2156 0.373783395008786 3073 5702181 A cholesterol synthesis inhibitor.
SGTC_983 1491-0821 12.2 µM -0.32284248296076 0.36767208783083 no 2157 0.373407268758831 3100 46495113
SGTC_1613 st002381 52.1 µM -0.323493685628516 0.367423978022063 no 2158 0.37316069441222 3006 551167
SGTC_1495 4469-0029 237 µM -0.323739888975884 0.367330188354196 no 2159 0.373067484379621 2957 793680
SGTC_453 enantio-paf c16 10 µM -0.324638486486599 0.366987940294163 no 2160 0.372727347763707 3085 13871343 A lipid and platelet activating factor
SGTC_3145 9085516 49.47 µM -0.325599118235825 0.366622182188741 no 2161 0.372363839709276 3074 25236195
SGTC_3059 1327-0034 3 µM -0.325630047964005 0.366610407783424 no 2162 0.372352137626549 2978 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_257 daunorubicin 18.5 µM -0.32662103979137 0.366233221066069 no 2163 0.371977264071535 3078 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3165 9101544 49.47 µM -0.328117238058348 0.365663989909476 no 2164 0.371411510392112 3081 5002184
SGTC_1190 1486-1332 13 µM -0.328313166005191 0.365589470660038 no 2165 0.371337445188921 3039 4150046
SGTC_1032 k061-1018 98.7 µM -0.328342437034402 0.365578338150134 no 2166 0.371326380485644 3175 4005393
SGTC_2822 7994718 71.43 µM -0.328571868475826 0.365491083514876 no 2167 0.371239657092115 2959 1018011
SGTC_625 k213-0058 121 µM -0.329523571143547 0.365129217647671 no 2168 0.37087999034712 3046 3655420
SGTC_2926 9010726 65.15 µM -0.330745646443212 0.364664724113971 no 2169 0.370418310010629 3102 2994293
SGTC_2344 7990960 76.95 µM -0.331073382044559 0.364540190192665 no 2170 0.370294528487748 3002 140813
SGTC_1074 carmofur 3.8 µM -0.332984174899091 0.363814406612844 no 2171 0.369573114384174 3002 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1093 fluphenazine 7.97 µM -0.33334171552557 0.363678654783166 no 2172 0.369438176887422 2991 6602611 An atypical antipsychotic.
SGTC_1861 st057647 17.4 µM -0.335111208548319 0.363007061901715 no 2173 0.368770599016746 3170 688668
SGTC_1259 0671-0132 43 µM -0.335580340212403 0.362829078332322 no 2174 0.368593675677498 3018 X1259
SGTC_1842 st055362 61.2 µM -0.335913432130935 0.362702724781629 no 2175 0.368468073830362 2995 676032
SGTC_2252 omeprazole 400 µM -0.336389599024547 0.362522123793254 no 2176 0.368288545872965 3006 4594 A proton pump inhibitor.
SGTC_1256 0570-0116 285 µM -0.33659177646618 0.362445451007771 no 2177 0.36821232813559 3022 410638
SGTC_2147 5545932 89.7195 µM -0.336796167147149 0.362367944492001 no 2178 0.368135281313581 3030 797404
SGTC_2277 7947813 106.88 µM -0.33740657262268 0.36213650764023 no 2179 0.367905215310753 3203 1246798
SGTC_2860 9025725 38.96 µM -0.339744541264467 0.361250527444768 no 2180 0.367024457847615 2966 40546248
SGTC_3170 9103054 49.47 µM -0.339824980635418 0.361220057912141 no 2181 0.366994167219261 3063 16432970
SGTC_1358 1509-0022 2.48 µM -0.340287860363902 0.361044741371001 no 2182 0.366819879145075 3074 3258434
SGTC_499 genistein 192 µM -0.342964836768295 0.360031405211269 no 2183 0.365812456863149 3076 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_949 1165-0505 146 µM -0.343724573503053 0.359743995042865 no 2184 0.365526714486495 3008 6244267
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.344109176818983 0.35959852893906 no 2185 0.365382090886137 2930 4000243
SGTC_1466 k213-0079 57.5 µM -0.345573653494575 0.359044815444412 no 2186 0.364831574442071 3019 3657981
SGTC_2908 7930301 100 µM -0.346638307380621 0.358642459280028 no 2187 0.364431531544185 3017 2223178
SGTC_973 1325-0077 65.9 µM -0.34708001885367 0.358475572788556 no 2188 0.364265602091675 3055 2835149
SGTC_724 3910-0327 137 µM -0.347846165253198 0.358186173086007 no 2189 0.363977858603068 3093 2885483
SGTC_871 0574-0004 149 µM -0.348171308779603 0.358063379864008 no 2190 0.363855766814525 2999 9551173
SGTC_895 0964-0006 13.7 µM -0.348921889106282 0.357779972894964 no 2191 0.363573975787705 3146 6738897
SGTC_3167 9103034 49.47 µM -0.350055660311225 0.357352027921129 no 2192 0.363148463033338 3059 5127859
SGTC_3097 9117246 49.47 µM -0.352557047266733 0.356408507673254 no 2193 0.362210271801255 3007 16423892
SGTC_3268 9137683 49.47 µM -0.354342965215765 0.355735398474465 no 2194 0.361540936109126 3013 1953228
SGTC_74 000s-0487 160.283 µM -0.355939528403191 0.355134037230212 no 2195 0.360942926207641 3066 677548
SGTC_2331 7980721 200 µM -0.357156820026272 0.354675774562852 no 2196 0.360487204742207 3073 2981221
SGTC_2476 5806916 10.51 µM -0.358413470656776 0.354202915303473 no 2197 0.360016956121474 3011 2870194
SGTC_2749 bexarotene 57.39 µM -0.359284579950788 0.353875261436767 no 2198 0.35969110435372 3115 82146 An retinoic acid receptor inhibitor.
SGTC_817 1391-0715 46 µM -0.360443020723535 0.353439700057986 no 2199 0.359257929849355 3079 1353946
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.360479316105153 0.353426056478354 no 2200 0.359244360875603 3028 364106
SGTC_2781 5567276 71.43 µM -0.361037962100533 0.353216082974557 no 2201 0.35903553431618 3189 2853274
SGTC_1178 0988-0033 191 µM -0.361090158907548 0.353196466487314 no 2202 0.359016024862279 3170 5392207
SGTC_779 1360-0071 233 µM -0.36113402475785 0.353179981223234 no 2203 0.358999629531016 3228 7566
SGTC_397 arbidol 50 µM -0.361317804737865 0.353110917701566 no 2204 0.358930942619391 3186 131410 A RNA synthesis inhibitor.
SGTC_828 2074-0507 139 µM -0.361449282538789 0.353061512024274 no 2205 0.358881806202089 3186 X828
SGTC_694 1315-0438 43.2 µM -0.362451533278926 0.352684975713087 no 2206 0.358507317785729 3072 6793154
SGTC_1663 st014140 55.4 µM -0.362571024073099 0.352640093748177 no 2207 0.358462679425469 3083 4207120
SGTC_2038 4100038 30.985 µM -0.362972426786066 0.352489337803877 no 2208 0.358312740957907 3137 3596803
SGTC_322 k048-0136 19.3 µM -0.363121081875664 0.352433512872 no 2209 0.358257218433658 3139 6823282
SGTC_1052 3253-3998 198 µM -0.363694840175097 0.3522180773613 no 2210 0.358042948410876 3002 5450317
SGTC_69 0096-0274 206.684 µM -0.364349955360591 0.35197215184 no 2211 0.357798350330763 3320 6741392
SGTC_2957 9076800 11.52 µM -0.365260005259319 0.351630628411876 no 2212 0.357458665054177 3062 16459615
SGTC_445 e6 berbamine 66 µM -0.366705554596585 0.351088389003344 no 2213 0.356919331409466 3134 6610268 A calcium/calmodulin antagonist.
SGTC_360 0957-0399 1.01 µM -0.370101608398396 0.349815690622773 no 2214 0.355653391873019 3193 6752301 YPR165W RHO1
SGTC_1619 st003326 88.7 µM -0.371367828154647 0.349341595258068 no 2215 0.355181792205205 3197 2849032
SGTC_2993 9054257 71.4286 µM -0.372540895978908 0.348902587285856 no 2216 0.35474508451863 3020 6470217 YGL055W OLE1
SGTC_3117 9124945 49.47 µM -0.374430064164817 0.348196011674815 no 2217 0.354042189508754 3002 17592065
SGTC_2847 9005661 71.43 µM -0.374633627318418 0.348119907563055 no 2218 0.353966480231379 3145 2991449
SGTC_66 0109-0187 42.4 µM -0.375202308258726 0.347907332949675 no 2219 0.353755006824838 3081 759417
SGTC_1559 coumarin 343 70.1 µM -0.376318021222593 0.347490415070843 no 2220 0.353340241664826 3229 108770 A hepatotoxic, DNA x-linker.
SGTC_250 brefeldin a 552.239 µM -0.376341538237681 0.347481629252249 no 2221 0.353331501110421 3042 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_2160 5660466 132.927 µM -0.377808582448322 0.346933712311125 no 2222 0.35278639879936 3158 2859134
SGTC_320 4092-0846 5.34 µM -0.37781394933775 0.346931708452599 no 2223 0.352784405204879 3152 1359356
SGTC_2023 5144124 124 µM -0.379172292801114 0.346424675718864 no 2224 0.352279962596331 3054 2830192
SGTC_536 3852-0578 10.6 µM -0.380393409206633 0.345969100859547 no 2225 0.351826703140161 3213 2869208
SGTC_528 3492-0019 172 µM -0.38102913552797 0.345732011868664 no 2226 0.351590814678244 3154 2869262
SGTC_1134 3477-0009 42.5 µM -0.381681221644789 0.345488884465363 no 2227 0.351348915214745 3295 3973534
SGTC_516 3992-2719 87.3 µM -0.3824435184585 0.345204746295094 no 2228 0.351066208047286 2995 5350887 YDR037W KRS1
SGTC_2673 kobusone 100 µM -0.383211526728483 0.344918567454037 no 2229 0.350781466051849 3096 6710676 An epoxy ketone and protein crosslinker.
SGTC_1113 artemisinin 1.17947 µM -0.383910895162343 0.344658042660081 no 2230 0.35052224542542 3176 2240 An anti-malaria and mitochondrial poison.
SGTC_2625 euphol 100 µM -0.384118893981723 0.344580574315377 no 2231 0.350445164168566 3217 6708538 A triterpene alcohol.
SGTC_2287 7945887 168.79 µM -0.384295448627539 0.344514822343956 no 2232 0.350379740485001 3161 1245853
SGTC_3074 9116018 49.47 µM -0.384674066543527 0.344373834394513 no 2233 0.350239455668915 3048 17027303
SGTC_2218 6965428 192.983 µM -0.386139506670814 0.343828344683025 no 2234 0.349696676201794 3166 675684
SGTC_3159 9100096 49.47 µM -0.386193031518495 0.343808426947033 no 2235 0.349676857118788 3008 25236875
SGTC_2296 7971656 126.45 µM -0.389379908392565 0.342623305191942 no 2236 0.348497566207749 3157 666570
SGTC_1373 2887-0003 58.5 µM -0.390331678578139 0.342269664630919 no 2237 0.348145650644788 3134 776948
SGTC_773 4358-1457 44.6 µM -0.391984856442736 0.341655737229566 no 2238 0.347534701533365 3245 1186886
SGTC_2001 4023502 57.655 µM -0.392105833161882 0.34161082749451 no 2239 0.347490008849629 3188 108941 YCR052W RSC6
SGTC_2721 ifenprodil 61.44 µM -0.392995016185699 0.341280808242653 no 2240 0.347161581186091 3232 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1156 4092-0367 4.88 µM -0.393609742527376 0.341052724201086 no 2241 0.346934593613752 3134 1357585
SGTC_2145 5634607 200 µM -0.39402947971305 0.340897021018073 no 2242 0.346779637291613 3088 308662
SGTC_1944 st076371 56.9 µM -0.394970684165562 0.340547976011941 no 2243 0.346432261674063 3068 24208455
SGTC_1205 4161-2785 76 µM -0.395376338206006 0.340397581578812 no 2244 0.346282584457145 3182 3498106
SGTC_3 0833-0587 95.581 µM -0.395612491707453 0.340310040403714 no 2245 0.346195460180012 3159 5382644
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.396111136425646 0.340125223039109 no 2246 0.346011521576618 3278 5393153
SGTC_1451 4152-0210 104 µM -0.396136105635575 0.340115969476233 no 2247 0.346002311962344 3249 659563
SGTC_2489 cantharidin 73.42 µM -0.396816242979578 0.339863948348486 no 2248 0.345751485948609 3122 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_291 SEC14.278 35.5 µM -0.398979563434662 0.339062818147198 no 2249 0.344954131347221 3223 1068044
SGTC_3022 9087993 49.47 µM -0.400017840461601 0.338678576922454 no 2250 0.344571688303822 3192 17173644
SGTC_1243 0416-0003 5.65 µM -0.400103411370458 0.338646916679128 no 2251 0.344540175857475 3103 2141977
SGTC_1579 chlormadinone acetate 49.4 µM -0.400773763563183 0.338398933613788 no 2252 0.344293348494986 3222 45114258 A steroidal progestin.
SGTC_2444 5485484 36.41 µM -0.400845918438868 0.338372245570281 no 2253 0.344266784623911 3218 6790631
SGTC_797 k781-0471 270 µM -0.402809307916051 0.337646355459228 no 2254 0.34354425660444 3100 23738129
SGTC_1043 0916-0009 19.3 µM -0.402930657404408 0.337601510785493 no 2255 0.343499618668874 3289 3101130
SGTC_963 1269-2853 151 µM -0.403233935406568 0.337489444558232 no 2256 0.343388068584362 3101 3668223
SGTC_1992 st073643 23.3 µM -0.403887026622788 0.33724816551937 no 2257 0.343147898410833 3100 3161292
SGTC_3301 9125354 19.7965 µM -0.404146927665469 0.337152165881533 no 2258 0.343052339057144 3111 41905162
SGTC_1775 st081588 35.1725 µM -0.404601757216731 0.336984191025681 no 2259 0.342885133340365 3172 1426443 YGL099W LSG1
SGTC_919 tnp00227 403.569 nM -0.404886409925583 0.336879081369802 no 2260 0.342780504163615 3114 1269246 A methoxyflavone. YNL221C POP1
SGTC_3217 9129673 49.47 µM -0.406758336744725 0.336188179225561 no 2261 0.342092744803537 3286 17248312
SGTC_254 nsc-64875 3.808 µM -0.406807052272367 0.336170206374739 no 2262 0.342074853348825 3278 56993
SGTC_2385 9074692 200 µM -0.407643616834817 0.335861627102249 no 2263 0.34176766873801 3142 17046906
SGTC_521 r062-0005 13.8 µM -0.407665520735204 0.335853549008279 no 2264 0.341759627081754 3098 2832033
SGTC_1004 4084-0029 199 µM -0.40994132922986 0.335014651411489 no 2265 0.340924493393745 3251 716894 YLR208W SEC13
SGTC_1812 st052057 4.327 µM -0.410709955942642 0.334731509501823 no 2266 0.340642612868313 3093 3645418
SGTC_182 3448-4371 550.524 µM -0.411031275056336 0.334613171807817 no 2267 0.340524801015431 3213 3491403
SGTC_1737 st035557 69.7 µM -0.411764694193637 0.334343124533294 no 2268 0.340255950734942 3153 5716916
SGTC_2143 5623677 140.463 µM -0.412009068772372 0.334253164060505 no 2269 0.340166388094825 3210 5375313
SGTC_3031 9088762 49.47 µM -0.413736919325055 0.33361737036119 no 2270 0.339533392939306 3072 205253
SGTC_1792 st045773 43.6 µM -0.41427252710165 0.333420380714534 no 2271 0.339337265698853 3104 2919270
SGTC_2057 5236571 38.335 µM -0.414315221396676 0.333404680278121 no 2272 0.339321633902541 3301 54684039 YBR257W POP4
SGTC_2949 9072542 2.23 µM -0.414825911018142 0.333216901472759 no 2273 0.339134674949205 3210 16457352
SGTC_1607 st000305 50.6 µM -0.415935571423651 0.332809027322221 no 2274 0.338728574658407 3265 5457690
SGTC_1236 0330-0013 258 µM -0.416548676128213 0.332583755276257 no 2275 0.338504278249946 3130 4617066
SGTC_2801 7907800 81.82 µM -0.416556792657422 0.332580773438594 no 2276 0.338501309306932 3218 6620925
SGTC_1263 0774-1208 64.8 µM -0.416909737794813 0.332451119260009 no 2277 0.338372215311984 3310 906585
SGTC_2000 st075254 36.4 µM -0.417905508791476 0.332085431490252 no 2278 0.338008102341192 3189 17234175
SGTC_3239 9133757 49.47 µM -0.418320462354722 0.33193309076523 no 2279 0.337856415393149 3156 17036923
SGTC_3154 9100113 49.47 µM -0.41840413746917 0.331902374722685 no 2280 0.33782583100846 3131 25237525
SGTC_1649 st011737 51.3 µM -0.418424678515701 0.331894834545272 no 2281 0.337818323142149 3191 1761035
SGTC_1765 st044815 90.4 µM -0.420294923289106 0.331208593465453 no 2282 0.337135009052534 3225 645695
SGTC_2513 baicalein 25.65 µM -0.420323794037019 0.331198004477094 no 2283 0.337124465016578 3176 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2992 9074591 71.4286 µM -0.421118753165149 0.330906488605926 no 2284 0.336834184152163 3268 17741321
SGTC_627 1391-0720 175 µM -0.422533233834044 0.330388044316555 no 2285 0.336317924139989 3205 997839
SGTC_850 0388-0143 75.9 µM -0.422687373291795 0.330331567803157 no 2286 0.336261684632279 3151 67273
SGTC_580 1123-0028 41 µM -0.42379229196643 0.32992684012818 no 2287 0.335858650013592 3161 1677248 YPR107C YTH1
SGTC_2748 diazoxide 86.69 µM -0.424013541930368 0.329845820973737 no 2288 0.335777968639485 3189 3019 A potassium channel activatior.
SGTC_976 1348-1067 47.6 µM -0.424391798718017 0.329707326243136 no 2289 0.335640050432486 3152 5310671 YGL099W LSG1
SGTC_3243 9134147 49.47 µM -0.425764082439358 0.329205075153652 no 2290 0.335139880775114 3243 24282180
SGTC_1882 5615643 20 µM -0.426284706432455 0.329014609140425 no 2291 0.334950200262529 3228 2253075
SGTC_1478 0453-0656 35.7 µM -0.427016863418432 0.328746830624174 no 2292 0.33468352252468 3232 5258496
SGTC_1065 prochlorperazine maleate 2.48 µM -0.427609025208072 0.328530318126094 no 2293 0.334467897011118 3244 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_284 0988-0104 32.6 µM -0.428358243982478 0.328256463269562 no 2294 0.33419516014187 3218 4666532
SGTC_778 3456-2434 196 µM -0.428675149764303 0.328140655454063 no 2295 0.334079823785758 3264 5539063
SGTC_775 4577-0580 57.3 µM -0.429063505066075 0.327998760152951 no 2296 0.333938505080809 3354 2006902
SGTC_1883 5-benzylidenerhodanine 20 µM -0.429294874369847 0.327914235401824 no 2297 0.333854323240214 3259 1273210
SGTC_361 000s-0510 1.45 µM -0.431521086222917 0.327101397809973 no 2298 0.333044761950587 3220 660
SGTC_42 0133-0086 60.653 µM -0.432227422118956 0.32684367051288 no 2299 0.332788065396999 3103 162923 Model of phenazepam hydroxylation.
SGTC_3213 9129884 49.47 µM -0.434259974855964 0.326102495334091 no 2300 0.33204983271381 3223 17190742
SGTC_1817 st052116 64.4 µM -0.434446896925087 0.326034368180863 no 2301 0.331981974407577 3292 4361398
SGTC_1033 k072-0102 21.3 µM -0.434465946008265 0.326027425721468 no 2302 0.331975059329549 3303 5965931
SGTC_53 0973-0023 39.979 µM -0.434588446160222 0.325982781846782 no 2303 0.331930591464495 3333 674768
SGTC_3092 9117248 49.47 µM -0.435961624350294 0.325482512519088 no 2304 0.331432286432354 3241 17141857
SGTC_2866 9034245 58.44 µM -0.438413405928063 0.324590073704138 no 2305 0.330543315074704 3197 6462273
SGTC_2198 6589944 200 µM -0.439001041285179 0.324376326046799 no 2306 0.330330390912626 3230 5290268
SGTC_3280 9140961 49.47 µM -0.440438288058296 0.323853782938859 no 2307 0.329809849574496 3145 4901226
SGTC_2323 6148992 148.28 µM -0.441658128402689 0.323410554939763 no 2308 0.329368306791192 3170 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_1450 4112-4260 37.6 µM -0.441740086901832 0.323380784358631 no 2309 0.329338648983277 3302 1633175
SGTC_1500 4488-1866 171 µM -0.442249870548714 0.32319563609326 no 2310 0.329154200889126 3327 2900003
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.443990755977825 0.322563694424267 no 2311 0.328524633632335 3283 521171
SGTC_864 0469-0573 172 µM -0.444632861024721 0.322330739408269 no 2312 0.328292547891449 3197 689425
SGTC_826 1683-5028 118 µM -0.444668171892705 0.322317930686331 no 2313 0.328279786871381 3263 722377
SGTC_2379 9035213 200 µM -0.444760312345158 0.322284508501579 no 2314 0.328246489110367 3314 646551
SGTC_2059 5238311 157 µM -0.445232697661952 0.32211318234187 no 2315 0.328075799712812 3131 703021
SGTC_1758 st042942 75.2445 µM -0.449150969459659 0.320693551161995 no 2316 0.326661377134879 3276 669317
SGTC_2030 5175110 200 µM -0.449952881673708 0.320403332025646 no 2317 0.326372207895064 3304 2831986
SGTC_2089 5281248 129.67 µM -0.450442273905979 0.320226270577667 no 2318 0.326195784491461 3229 2737878
SGTC_2376 9072922 81.32 µM -0.452242581897506 0.319575274023452 no 2319 0.325547117547671 3323 17087968
SGTC_1463 k081-0032 34.1 µM -0.453791045660169 0.319015789378828 no 2320 0.324989614556764 3252 977755
SGTC_3187 9109394 49.47 µM -0.453826839295026 0.319002861435951 no 2321 0.324976732179563 3222 17098090
SGTC_2222 6885208 172.143 µM -0.454615386141828 0.318718110010453 no 2322 0.324692981814941 3236 609514
SGTC_1392 3455-1037 33.9 µM -0.455327167809725 0.318461171064374 no 2323 0.324436941929001 3340 981132
SGTC_2561 acetosyringone 100 µM -0.456156053336342 0.318162069978471 no 2324 0.324138882379882 3152 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_2459 5811157 9.22 µM -0.456350547464087 0.318091904464952 no 2325 0.324068960410334 3278 2870684 YBR192W RIM2
SGTC_327 1273-0057 3.96 µM -0.456595677560089 0.318003480867422 no 2326 0.323980843303675 3227 3108138
SGTC_323 4013-0906 34.3 µM -0.456597843294832 0.318002699687432 no 2327 0.323980064829263 3281 2910086
SGTC_2945 9067681 61.76 µM -0.458086545254044 0.317465917001669 no 2328 0.323445132472271 3311 16456930
SGTC_2954 9074818 52.69 µM -0.458166090549538 0.317437246065144 no 2329 0.323416559872203 3335 16648742
SGTC_189 3970-0742 2.116 µM -0.458861344484762 0.31718669860544 no 2330 0.32316686961224 3361 2891807
SGTC_1650 st011916 45.8 µM -0.460704251178438 0.316522979050244 no 2331 0.32250540229613 3337 242528
SGTC_3045 9092950 49.47 µM -0.462897495819618 0.315733855385223 no 2332 0.321718921281295 3361 44120432
SGTC_1293 1000-1278 195 µM -0.462910823406145 0.3157290627165 no 2333 0.321714144545628 3330 678847
SGTC_1455 4262-0120 131 µM -0.464894835515478 0.315015947750487 no 2334 0.321003384551504 3389 1529587
SGTC_1819 st053448 58.6 µM -0.466527985916117 0.314429460076144 no 2335 0.320418810181208 3199 2857616
SGTC_2204 7233102 200 µM -0.470585033687111 0.31297454410566 no 2336 0.318968548675092 3230 2172480
SGTC_596 1155-0152 116 µM -0.471028233624546 0.312815781980955 no 2337 0.318810286497203 3261 280313
SGTC_2096 5468907 200 µM -0.471080920007001 0.312796911086889 no 2338 0.318791474923852 3300 759785
SGTC_1929 genistein trimethyl ether 50.5 µM -0.471986005028405 0.312472809773362 no 2339 0.318468388962282 3392 136420
SGTC_1623 st003709 20.3 µM -0.473061809963854 0.312087764080472 no 2340 0.318084541037363 3226 16192618
SGTC_3156 9099931 49.47 µM -0.473075530974104 0.312082854462686 no 2341 0.318079646632264 3188 18111053
SGTC_2594 a-mangostin 100 µM -0.474059934206243 0.311730704889659 no 2342 0.31772858428379 3354 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_2291 7917025 104.35 µM -0.474552212910466 0.311554667050276 no 2343 0.317553087035879 3177 2964612
SGTC_2683 piperine 63.03 µM -0.475737431455285 0.311131012086372 no 2344 0.317130725113254 3252 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.477799649960062 0.310394470931737 no 2345 0.316396405161262 3331 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_611 3453-1652 23.7 µM -0.479683896986503 0.309722157992274 no 2346 0.315726089944489 3364 1560575
SGTC_2936 9038235 15.59 µM -0.481100878967092 0.309216987437411 no 2347 0.315222401706 3259 4749415
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.483832437203262 0.308244172938215 no 2348 0.314252396248265 3234 6857784
SGTC_1697 st025554 27.742 µM -0.486403875543964 0.307329612299219 no 2349 0.313340421656045 3245 1269519
SGTC_1673 st016611 27.3 µM -0.486464441062727 0.307308085903852 no 2350 0.313318955488239 3375 5226799
SGTC_970 1315-0089 19.5 µM -0.486731412260592 0.30721320603808 no 2351 0.313224340729793 3330 6811083 YLR033W RSC58
SGTC_1925 st057770 10.1 µM -0.487235227067975 0.307034188616826 no 2352 0.313045821944255 3237 5989122
SGTC_1051 3253-3903 78 µM -0.487669321295442 0.306879981462902 no 2353 0.31289204267995 3206 5509239
SGTC_52 0329-0193 875 nM -0.48793126065399 0.306786946940132 no 2354 0.312799265572377 3435 3739292
SGTC_3267 9137951 49.47 µM -0.488338294139051 0.306642403188802 no 2355 0.312655120659061 3212 16643986
SGTC_1962 st076595 64.5 µM -0.488527403649013 0.306575257768063 no 2356 0.312588160057719 3271 279619
SGTC_1204 4049-0315 18.3 µM -0.489272813966981 0.306310654844342 no 2357 0.312324282652764 3434 588402
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.490842208981314 0.30575388719952 no 2358 0.311769026974384 3289 689007
SGTC_1976 st070609 63.5 µM -0.491186619682866 0.305631762064916 no 2359 0.311647230826208 3288 682556
SGTC_947 3447-0010 211 µM -0.491989202651112 0.305347256806404 no 2360 0.311363488266794 3348 748350
SGTC_975 1335-0046 28.5 µM -0.495025845224162 0.30427187115428 no 2361 0.310290938443096 3275 16486740
SGTC_1518 st038567 90.8 µM -0.498041330833043 0.303205650341606 no 2362 0.309227455559818 3358 77966
SGTC_1957 st077035 62.4 µM -0.498643986025168 0.302992762895996 no 2363 0.309015105961468 3400 705593
SGTC_2327 6189656 200 µM -0.498838193086195 0.302924173666434 no 2364 0.308946689391714 3350 5349088
SGTC_2998 9066762 71.4286 µM -0.499224056510595 0.302787916678538 no 2365 0.308810774497171 3451 4945196
SGTC_1360 1598-0022 39.8 µM -0.501208610709496 0.302087560338534 no 2366 0.308112157448232 3364 761525
SGTC_3050 9093513 49.47 µM -0.501918614368826 0.301837174264117 no 2367 0.307862385437084 3349 25236664
SGTC_2084 5306078 60.6385 µM -0.502149736440442 0.301755688123494 no 2368 0.307781098256153 3262 679340
SGTC_3305 9127027 53.8275 µM -0.503479388813339 0.301287088090835 no 2369 0.307313633955839 3265 41905295
SGTC_1911 st060208 74.3 µM -0.503916052211728 0.301133269393333 no 2370 0.307160184933946 3350 688783
SGTC_671 0560-0003 407 µM -0.504237855452506 0.301019933895319 no 2371 0.30704712082641 3275 3238678
SGTC_2275 7947463 200 µM -0.505105913322879 0.300714309567216 no 2372 0.306742224144518 3380 1225414
SGTC_1159 4092-0538 61.2 µM -0.506053707612285 0.300380771791019 no 2373 0.306409473481116 3359 717301
SGTC_383 2324-0395 7.37 µM -0.50663971460786 0.300174634046952 no 2374 0.306203818546917 3395 3146421
SGTC_1303 1160-0052 261 µM -0.507450798257241 0.299889427421017 no 2375 0.305919275316951 3371 3562476
SGTC_2733 amorolfine 100 µM -0.507867489531812 0.299742951266405 no 2376 0.305773137788051 3351 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2881 9058953 51.95 µM -0.507869865671947 0.299742116093765 no 2377 0.305772304542125 3261 17122249
SGTC_1304 1165-0502 251 µM -0.508544141658919 0.299505162206271 no 2378 0.305535895442619 3283 767425
SGTC_1530 rhein 70.4 µM -0.509794986240058 0.299065815753393 no 2379 0.305097549306617 3372 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_3200 9114385 49.47 µM -0.510005892757821 0.298991765818136 no 2380 0.305023666715414 3403 17018030 YLR208W SEC13
SGTC_1291 0993-0025 5.79 µM -0.510755339964597 0.298728699960041 no 2381 0.304761192423978 3431 4353356
SGTC_2947 9072639 7.68 µM -0.510964857619297 0.298655175321528 no 2382 0.304687832304865 3389 16488146
SGTC_3112 9123419 49.47 µM -0.511365891580935 0.298514466090641 no 2383 0.304547436928688 3392 17015854
SGTC_1597 7-benzyloxygramine 47.5 µM -0.511850109388014 0.298344610669425 no 2384 0.304377958626723 3371 260807
SGTC_1362 1611-0397 101 µM -0.513399716077929 0.297801330755199 no 2385 0.303835872078517 3315 27816
SGTC_223 busulfan 5 mM -0.513882927863169 0.297632012840929 no 2386 0.303666922082072 3377 2478 A DNA alkylator.
SGTC_94 0334-0113 514.748 µM -0.514014805044179 0.297585810571543 no 2387 0.303620819876588 3340 6795178
SGTC_941 3237-0776 460 µM -0.514188032650381 0.297525126438118 no 2388 0.303560266955947 3424 760008
SGTC_2463 5473429 200 µM -0.514385777784885 0.297455860366922 no 2389 0.303491150354305 3321 5399405
SGTC_2984 9022109 38.96 µM -0.515276218353115 0.297144048550488 no 2390 0.303180007444107 3435 6459207
SGTC_2617 dihydrotanshinone i 20.83 µM -0.516347066091094 0.296769260335325 no 2391 0.302806014661698 3288 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1711 st032263 62.8 µM -0.517435652737688 0.296388485613895 no 2392 0.302426038479917 3347 3958979
SGTC_2190 6049624 200 µM -0.517596971442101 0.296332077300339 no 2393 0.302369747639012 3340 2265554
SGTC_2135 5326629 150.42 µM -0.51903413553651 0.295829761525876 no 2394 0.301868468570355 3301 5020077
SGTC_3304 9125678 46.087 µM -0.519201916600097 0.295771144405686 no 2395 0.301809971326472 3306 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_3090 9117696 49.47 µM -0.522473172126887 0.294629344446464 no 2396 0.300670460429698 3311 7923821
SGTC_2015 5119600 184 µM -0.523018147243239 0.294439323939476 no 2397 0.300480812361679 3426 2828786
SGTC_390 dec-rvkr-cmk 16.7 µM -0.523045937606643 0.294429635583956 no 2398 0.300471142930074 3366 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_999 SEC7.066 22.7 µM -0.523340832294529 0.294326837626681 no 2399 0.300368545374512 3320 740511 YDR170C SEC7
SGTC_1078 idebenone 36.1 µM -0.523644767245685 0.294220905652823 no 2400 0.300262819166387 3377 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_771 0250-0039 27.3 µM -0.524840846237118 0.293804201381609 no 2401 0.299846916964071 3305 3005115
SGTC_3146 9095609 49.47 µM -0.526154611260301 0.293346811168807 no 2402 0.299390393617738 3349 17173999
SGTC_2664 lyso-paf C-16 73.48 µM -0.526905855834868 0.293085412076179 no 2403 0.299129483578587 3324 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1615 st002656 86.5 µM -0.528241355516761 0.292620985605468 no 2404 0.298665914573219 3431 1584458
SGTC_2253 7938677 135.83 µM -0.52839642936777 0.292567080086611 no 2405 0.298612107630719 3454 2301972
SGTC_1898 st060199 18.6 µM -0.52965641231364 0.29212926615019 no 2406 0.298175086998623 3385 688866
SGTC_342 k048-0088 23.3 µM -0.531056460143187 0.291643140950912 no 2407 0.297689827346757 3309 6820570
SGTC_1182 1222-0449 220 µM -0.532374812457541 0.291185727137251 no 2408 0.297233213232584 3385 658318
SGTC_838 0109-0203 71.4 µM -0.532880729412332 0.291010283823747 no 2409 0.297058072852753 3388 759422
SGTC_2553 4-methylesculetin 85.09 µM -0.535123823512995 0.290233012822415 no 2410 0.296282118582798 3380 5319502
SGTC_1219 1469-0211 33.1 µM -0.535471868029815 0.290112496572872 no 2411 0.296161802781334 3402 6822282
SGTC_2223 6903751 107.57 µM -0.536999433818716 0.28958382885803 no 2412 0.295634002572024 3402 5598863
SGTC_2943 9068529 45.32 µM -0.537696045739384 0.289342892128406 no 2413 0.295393454819238 3444 3270634
SGTC_1662 st014054 52 µM -0.537826962809217 0.289297622440068 no 2414 0.295348257769357 3395 2838777
SGTC_2674 ligustilide 100 µM -0.537899644780983 0.289272491247625 no 2415 0.295323166840708 3399 5319022 A signalling regulator.
SGTC_2248 tofa 1.1 µM -0.538827155256086 0.28895187675754 no 2416 0.295003062196838 3304 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_3175 9106517 49.47 µM -0.539013884338754 0.288887349948737 no 2417 0.294938637141658 3408 41468073
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.539456528376287 0.288734415297051 no 2418 0.29478594250669 3399 6312947
SGTC_1364 1653-0028 37.6 µM -0.540771999737384 0.288280141704098 no 2419 0.294332372314451 3397 5718652
SGTC_2759 disulfiram 3.38 µM -0.541753199367567 0.287941522264731 no 2420 0.293994267897699 3343 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2401 5128683 200 µM -0.543047456457271 0.287495151765789 no 2421 0.293548564147859 3343 708373
SGTC_1505 k297-0037 20.6 µM -0.543794548154579 0.287237639713943 no 2422 0.29329143044628 3327 4089396
SGTC_662 k832-1615 104 µM -0.54489579135571 0.286858255770412 no 2423 0.292912595503602 3397 5878478
SGTC_1422 4031-0024 15.5 µM -0.544980652550895 0.286829030509523 no 2424 0.292883412118103 3392 782427
SGTC_2912 7964298 10.93 µM -0.545353759889119 0.286700553196088 no 2425 0.292755118186804 3426 2975850
SGTC_1594 piperine 70.1 µM -0.54703466112015 0.286122083385178 no 2426 0.292177459780162 3403 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2767 sibutramine 71.45 µM -0.5471421719905 0.286085103183413 no 2427 0.292140530654218 3508 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_426 0988-0037 14.6 µM -0.547267138968403 0.28604212150915 no 2428 0.292097608224589 3487 5383008
SGTC_1716 st033144 30.6155 µM -0.548193971872629 0.285723438470098 no 2429 0.291779360414584 3500 674617
SGTC_1092 toremifene 6.32 µM -0.54885960157358 0.285494672025968 no 2430 0.291550902012189 3431 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1790 st045711 43.5 µM -0.551663986489628 0.28453180792868 no 2431 0.290589294159535 3503 585119
SGTC_216 k038-0035 28.382 µM -0.552353703259755 0.284295236804989 no 2432 0.290353021705392 3416 4444231 YPR107C YTH1
SGTC_2298 7976326 193.81 µM -0.554095731284107 0.28369814452566 no 2433 0.289756665690059 3370 2235818
SGTC_1383 3049-0032 20.7 µM -0.554271882378027 0.283637800960002 no 2434 0.289696395131507 3478 712864
SGTC_969 1313-0238 134 µM -0.555409791333664 0.283248139033349 no 2435 0.289307198435929 3362 5212874
SGTC_692 k241-0027 77.8 µM -0.556916179556318 0.282732691527412 no 2436 0.288792349809905 3520 3600480
SGTC_675 1309-0189 238 µM -0.557441986867562 0.282552879889625 no 2437 0.288612742651842 3388 4246530
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.557596323522386 0.282500111437683 no 2438 0.288560033771508 3441 16623 A steroid.
SGTC_1565 sinapyl alcohol 95.1 µM -0.560696733108631 0.281441071332335 no 2439 0.287502147325471 3432 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1633 st005664 67.9 µM -0.561326228449964 0.281226282060113 no 2440 0.287287582272944 3400 2063822
SGTC_2743 auranofin 4.32 µM -0.561432351411754 0.281190079782939 no 2441 0.287251417462763 3373 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1625 st003711 30.1 µM -0.562428085413982 0.28085050954113 no 2442 0.286912194089278 3526 24207034 YER133W GLC7
SGTC_992 3909-8734 162 µM -0.563401948539893 0.280518589702276 no 2443 0.286580605322261 3397 4288319
SGTC_264 promethazine 12.5 mM -0.564215752565569 0.280241368182683 no 2444 0.286303654259926 3530 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1875 nocodazole 6 µM -0.564411491118013 0.280174709846986 no 2445 0.286237060133192 3498 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2750 bromebric acid 70.15 µM -0.564699886613944 0.28007651139213 no 2446 0.286138955686924 3472 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1704 st028805 70.8 µM -0.56646389556679 0.279476230979954 no 2447 0.285539234863456 3438 2876101
SGTC_2036 5160441 105 µM -0.56811291999728 0.278915644658718 no 2448 0.284979147678552 3432 134534 YIL048W NEO1
SGTC_1199 1638-0010 4.46 µM -0.568199255515804 0.278886309951961 no 2449 0.28494983846623 3379 3111136
SGTC_3199 9111318 49.47 µM -0.568589654637585 0.278753680581909 no 2450 0.284817323586467 3416 8548020
SGTC_1077 5-fluorocytosine 377 nM -0.569555995572832 0.278425519977342 no 2451 0.284489440793065 3453 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1380 2291-0730 164 µM -0.569883453227886 0.278314361051092 no 2452 0.28437837420313 3406 2999191
SGTC_471 1-acyl-paf 4 µM -0.570024419040053 0.278266515393375 no 2453 0.284330568013769 3391 16759367
SGTC_55 0767-0285 6.563 µM -0.572508928352621 0.277423898947552 no 2454 0.283488619431158 3470 3116166
SGTC_2711 st079103 59.1 µM -0.572636483882698 0.277380672426137 no 2455 0.283445425780271 3411 54693780
SGTC_772 k072-0172 35.3 µM -0.573742337940303 0.277006054330831 no 2456 0.283071086856472 3399 5861980
SGTC_667 1498-1044 59 µM -0.575531598502302 0.276400451117052 no 2457 0.282465913307646 3432 6739982
SGTC_1367 1812-0510 76.9 µM -0.577231040719112 0.275825850269807 no 2458 0.281891695349606 3433 1142582 YDR527W RBA50
SGTC_3355 9151058 44.0485 µM -0.578083263263694 0.275537925215057 no 2459 0.281603953060717 3496 17015728
SGTC_901 1112-0062 60.1 µM -0.578891931355862 0.275264851865465 no 2460 0.281331047429519 3466 1908457
SGTC_2191 5911152 200 µM -0.580385728842823 0.274760772651316 no 2461 0.280827263419843 3438 2875902
SGTC_187 1488-2104 32.728 µM -0.581077208411374 0.274527588336276 no 2462 0.280594209337808 3484 2852859
SGTC_131 0141-0277 33.849 µM -0.581864392714499 0.274262248878681 no 2463 0.280329013196216 3478 1547771
SGTC_2701 st077767 14.721 µM -0.583052095653178 0.273862144789173 no 2464 0.279929115385249 3468 5721188
SGTC_1394 3474-0001 65.7 µM -0.583381217017324 0.273751324041986 no 2465 0.279818349680726 3412 5017666 YIL048W NEO1
SGTC_3221 9128209 49.47 µM -0.58352634602781 0.273702463689519 no 2466 0.279769513307757 3465 16460723
SGTC_682 0kpi-0099 17 µM -0.584321957681121 0.273434683057427 no 2467 0.279501860958024 3501 1714895 YML126C ERG13
SGTC_1007 4101-0031 70 µM -0.584981999933189 0.273212629776184 no 2468 0.279279910024353 3510 1146276
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.585984714126279 0.272875464876952 no 2469 0.27894289353672 3412 390807
SGTC_1506 4226-2149 212 µM -0.586188391908694 0.272807002989914 no 2470 0.278874460754023 3469 991114
SGTC_1764 st044502 93.5 µM -0.5872746817723 0.27244201408626 no 2471 0.278509621133691 3504 8407
SGTC_2972 9093619 59.92 µM -0.587850247005107 0.272248724885114 no 2472 0.278316406974948 3380 25236256
SGTC_2373 9071805 200 µM -0.591255275451253 0.271106627133891 no 2473 0.277174695744479 3520 10149009
SGTC_290 2043-6722 48.1 µM -0.591799414844453 0.270924336269203 no 2474 0.276992457546718 3498 773758 YLR208W SEC13
SGTC_2818 7996756 12.99 µM -0.592231832023509 0.270779516829166 no 2475 0.276847678172428 3464 2241621
SGTC_693 4161-2696 114 µM -0.594476305385817 0.270028448929572 no 2476 0.276096792808505 3490 805759
SGTC_1729 st035615 45.989 µM -0.596316535609685 0.269413431534527 no 2477 0.275481893276796 3449 17385451
SGTC_3212 9128307 49.47 µM -0.599031913556855 0.268507218259991 no 2478 0.274575801626954 3327 27243542
SGTC_2924 9010168 62.78 µM -0.600198333864374 0.268118415475363 no 2479 0.274187031959504 3508 2993929
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.600225895283566 0.268109231857819 no 2480 0.274177848985525 3542 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2868 9035608 32.47 µM -0.600295122339691 0.268086165717537 no 2481 0.274154784433418 3524 6462614
SGTC_2974 9094440 9.66 µM -0.601386214254957 0.267722750843858 no 2482 0.273791389246356 3550 25236134
SGTC_1193 1488-0126 41.5 µM -0.602681798440218 0.267291547455634 no 2483 0.273360196183906 3529 1384710
SGTC_768 0384-0033 77.3 µM -0.604011479513408 0.266849360443911 no 2484 0.272918005042849 3445 3965305 YMR134W ERG29
SGTC_799 1310-0557 151 µM -0.60552218524547 0.266347422374846 no 2485 0.272416044187851 3558 5354492
SGTC_825 1988-2224 89.6 µM -0.606068592995083 0.266165993920403 no 2486 0.272234602753955 3503 1180859
SGTC_1508 1080-0625 72.9 µM -0.606312225192471 0.266085118805365 no 2487 0.272153721040513 3475 767111
SGTC_2177 5811945 192 µM -0.607129082253114 0.265814049230561 no 2488 0.271882625692528 3556 5343475
SGTC_2067 5224629 34.075 µM -0.608552949365912 0.265341881525299 no 2489 0.27141039962326 3545 2835000
SGTC_279 1273-0055 2.93 µM -0.609466434227414 0.265039185689871 no 2490 0.271107657354232 3531 2847562
SGTC_2768 sulfasalazine 50.2 µM -0.609924143233659 0.264887583482144 no 2491 0.270956029238892 3586 5384001 An antioxidant and salicylic acid derivative.
SGTC_934 2950-0684 338 µM -0.610485197029675 0.264701811595574 no 2492 0.270770223189803 3553 1121253
SGTC_2361 9034121 116 µM -0.611878324527121 0.264240816451758 no 2493 0.270309131765537 3490 6496917
SGTC_2657 nystatin 74.44 µM -0.613181646401658 0.263809909058042 no 2494 0.269878119519239 3554 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_258 haloperidol 50.781 µM -0.614449734335401 0.263390994974989 no 2495 0.269459089712524 3508 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_168 3970-0862 530.542 µM -0.614813815805883 0.263270783089327 no 2496 0.269338842104573 3553 3135186
SGTC_3256 9138902 49.47 µM -0.616979496161292 0.262556301455265 no 2497 0.268624124973837 3539 17228773
SGTC_3229 9132204 49.47 µM -0.617589602040792 0.262355200171426 no 2498 0.268422950237589 3524 17682924
SGTC_1320 1313-0481 95.3 µM -0.618464841141933 0.262066844276805 no 2499 0.268134483515506 3579 6813365 YLR208W SEC13
SGTC_1299 1079-1439 3.74 µM -0.619284512666429 0.26179694303117 no 2500 0.267864472651084 3472 323161
SGTC_1498 4478-3555 97.6 µM -0.620334656462243 0.261451360414011 no 2501 0.267518741359261 3544 3437919
SGTC_1668 st014914 51.6 µM -0.620405832698946 0.261427946129297 no 2502 0.267495316663155 3558 2839556
SGTC_841 0251-0215 91.2 µM -0.620558552488934 0.26137771073972 no 2503 0.267445058790983 3531 3888614
SGTC_728 3030-5151 22.5 µM -0.62059457374515 0.261365862691226 no 2504 0.267433205411135 3571 3125388
SGTC_203 k066-0004 30.888 µM -0.621189396885556 0.261170254400309 no 2505 0.267237507510405 3603 6795412
SGTC_370 0180-0345 38.7 µM -0.623774098000307 0.260321146990775 no 2506 0.266387976291072 3482 3989527
SGTC_643 k048-0106 28.4 µM -0.625290463125366 0.259823664410634 no 2507 0.265890219041018 3558 6763920
SGTC_2472 5377652 49.4 µM -0.626351690840267 0.259475793362512 no 2508 0.265542144322003 3531 1610903
SGTC_1216 1165-0504 9.65 µM -0.62675828205677 0.259342576296029 no 2509 0.265408846726905 3576 6304004
SGTC_1999 st074831 12.5 µM -0.626834508912193 0.259317604978242 no 2510 0.265383860157919 3499 17112523
SGTC_1366 1683-0113 21.9 µM -0.627533535755124 0.259088667237145 no 2511 0.26515478029276 3552 708623
SGTC_154 3389-1638 511.116 µM -0.62892763884832 0.258632397853712 no 2512 0.264698215270723 3481 5238686
SGTC_2565 isoliquiritigenin 100 µM -0.63054521903952 0.258103509585024 no 2513 0.26416896362559 3517 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_2528 xanthyletin 44.79 µM -0.63068397996381 0.25805816608106 no 2514 0.264123587932694 3574 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_3356 9151811 4.48 µM -0.630735656763565 0.258041280486785 no 2515 0.26410669030967 3524 1859254 YPR165W RHO1
SGTC_2345 9052315 157.45 µM -0.63161152684433 0.257755173736181 no 2516 0.263820376293719 3541 6469265
SGTC_2233 sulbentine 40.3845 µM -0.634237606353375 0.256898341505104 no 2517 0.262962884273537 3544 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.63556618016823 0.256465422238008 no 2518 0.262529609311778 3673 6728940
SGTC_1086 cerivastatin 2.18 µM -0.636294701252424 0.256228193188069 no 2519 0.262292178975846 3557 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_1838 st055369 84.5 µM -0.636358230163009 0.25620751162983 no 2520 0.262271479655456 3553 676036
SGTC_1739 st037196 92.5 µM -0.636771182024453 0.256073098181817 no 2521 0.262136949930507 3594 612214
SGTC_965 1291-5240 308 µM -0.637284206806102 0.255906162821135 no 2522 0.261969868137689 3574 2834598
SGTC_951 1171-0579 82.7 µM -0.637419044830749 0.255862296717402 no 2523 0.261925963183758 3580 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_500 h-89 112 µM -0.637480913026484 0.255842170795279 no 2524 0.261905819385227 3620 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1825 st052143 62.6 µM -0.638942505079484 0.255366950663178 no 2525 0.261430167673142 3608 674173
SGTC_3184 9108758 49.47 µM -0.639973073903356 0.255032150402983 no 2526 0.261095052426215 3587 902885
SGTC_2221 6807166 181.081 µM -0.639993689917102 0.255025455234834 no 2527 0.261088350866837 3532 674925
SGTC_1862 st057513 3.81 µM -0.640006138509933 0.255021412527776 no 2528 0.261084304298844 3561 5393163
SGTC_3027 9089541 49.47 µM -0.640869941768973 0.254740972477902 no 2529 0.260803593195005 3577 9943819
SGTC_1432 4049-0298 68.4 µM -0.641712114633317 0.254467710429303 no 2530 0.260530060911526 3599 741646
SGTC_1161 k007-0610 110 µM -0.642111270956707 0.254338248797273 no 2531 0.26040046914133 3631 5843850
SGTC_958 1222-0007 33 µM -0.642387567580112 0.254248655480217 no 2532 0.260310784967617 3644 7312461
SGTC_527 4476-4215 268 µM -0.642548534592019 0.254196467145929 no 2533 0.260258543409177 3529 4418754
SGTC_1927 st060202 13.8 µM -0.644430465006521 0.253586729244596 no 2534 0.259648167289134 3586 688887
SGTC_346 4513-0042 7.16 µM -0.644837216353541 0.25345504448664 no 2535 0.259516340728207 3590 2827372
SGTC_3109 9122853 49.47 µM -0.645528534401918 0.253231314419337 no 2536 0.259292366504091 3605 1234709
SGTC_199 4063-0024 41.6 µM -0.646014224692483 0.253074193439416 no 2537 0.259135071620626 3619 306215
SGTC_680 0417-1641 114 µM -0.647515100749624 0.252588983805696 no 2538 0.258649312238678 3560 2835990
SGTC_1128 3448-9350 235 µM -0.647880851939663 0.252470816502907 no 2539 0.258531008139289 3547 619386
SGTC_931 2812-0076 566 µM -0.648055258953156 0.252414479149644 no 2540 0.258474605165083 3597 3450959
SGTC_833 3852-0053 558 µM -0.648204477018274 0.252366283648187 no 2541 0.258426353320165 3641 3123681
SGTC_1286 0929-0070 131 µM -0.64850193763827 0.252270222197479 no 2542 0.258330179000913 3646 1420408
SGTC_93 0109-0045 59.227 µM -0.649006174733447 0.252107428737912 no 2543 0.25816719254051 3663 88733
SGTC_427 1354-0053 47.3 µM -0.650086064770784 0.25175897165275 no 2544 0.257818315041279 3647 6813657
SGTC_2634 4'-methoxyflavone 100 µM -0.654966592408831 0.250187308608759 no 2545 0.256244631731698 3576 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1393 3470-5649 58.2 µM -0.655523492925194 0.250008302787907 no 2546 0.256065382885208 3533 4108395
SGTC_2346 9031566 143.75 µM -0.655921955135206 0.249880265878796 no 2547 0.255937170521481 3567 4771086
SGTC_1675 st018485 24.5 µM -0.657182683918764 0.249475388303401 no 2548 0.255531729187487 3576 3323024
SGTC_3060 1327-0027 12.5 µM -0.65721654440847 0.249464518963428 no 2549 0.255520844525516 3531 16000455 YPR107C YTH1
SGTC_3118 9124250 49.47 µM -0.657938442052112 0.24923284709181 no 2550 0.255288843745058 3523 1504786
SGTC_1002 4049-0206 172 µM -0.657986241718225 0.249217511230732 no 2551 0.255273485954102 3634 4662749
SGTC_1109 tnp00067 928.257 nM -0.658040623470433 0.249200064208711 no 2552 0.255256013959541 3574 676295
SGTC_594 1487-1584 10.8 µM -0.658320305695572 0.249110345439294 no 2553 0.255166166373043 3577 5013332
SGTC_2556 citropten 84.59 µM -0.659090205182333 0.248863459514684 no 2554 0.254918922518317 3590 2775 A potential DNA crosslinker.
SGTC_2971 9092186 9.93 µM -0.659665487905585 0.248679066974915 no 2555 0.25473425934159 3547 25236400
SGTC_2606 farnesol 9.78 µM -0.662092715656685 0.247901881438694 no 2556 0.253955901960948 3636 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2985 9022375 71.43 µM -0.662842052528863 0.24766220987402 no 2557 0.253715858839197 3657 4939335
SGTC_2638 epoxomicin 18 µM -0.664091344838599 0.247262905433589 no 2558 0.253315924685412 3595 9915668 A protesome inhibitor.
SGTC_2098 5376439 882.5 nM -0.664720246330585 0.247062023436386 no 2559 0.253114720837891 3661 2844116
SGTC_1728 st035614 33.7865 µM -0.665633612227494 0.246770434140295 no 2560 0.252822658332938 3598 15945546
SGTC_756 0508-1999 28.3 µM -0.666088466674966 0.246625291990933 no 2561 0.252677277974123 3595 6753853
SGTC_1334 1486-0610 236 µM -0.667605834578844 0.246141437112789 no 2562 0.252192616176598 3619 3742339
SGTC_561 1550-0330 72.9 µM -0.667646282145512 0.246128546253465 no 2563 0.252179703549531 3589 6812934
SGTC_2859 9028643 45.46 µM -0.66864849977636 0.245809249719504 no 2564 0.251859863370623 3593 17151580
SGTC_312 4092-0653 6.84 µM -0.668919450684234 0.245722965663036 no 2565 0.251773430926582 3623 1148278
SGTC_861 0443-0273 110 µM -0.673117533379731 0.244388170649422 no 2566 0.250436260078281 3639 6149169
SGTC_753 1322-0200 289 µM -0.673349060644025 0.244314669609106 no 2567 0.250362623818212 3662 5403907
SGTC_2816 7982706 58.44 µM -0.673829477552671 0.244162193657416 no 2568 0.25020986589053 3630 2981853
SGTC_655 k060-0012 42 µM -0.67446057695623 0.24396197171075 no 2569 0.250009270663382 3594 5994525
SGTC_2178 5812956 200 µM -0.674490759476595 0.243952398255466 no 2570 0.249999679274407 3625 5403383
SGTC_2416 tofa 880 nM -0.674490759476595 0.243952398255466 no 2571 0.249999679274407 3572 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_670 4204-0025 119 µM -0.675217874359704 0.243721829287418 no 2572 0.24976867602691 3638 719039
SGTC_195 4234-0266 16.654 µM -0.676935984254817 0.243177482403697 no 2573 0.249223285849573 3633 2303354
SGTC_668 1682-0499 62.6 µM -0.677024260893283 0.243149531577923 no 2574 0.249195280769468 3660 682214
SGTC_1115 galangin 695.678 nM -0.677547021467198 0.242984046726161 no 2575 0.24902947333091 3681 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_829 1635-0120 117 µM -0.67776612645555 0.242914705072998 no 2576 0.248959995809771 3646 285054
SGTC_415 dibenzyl ketone 100 µM -0.680571564735457 0.242027795740421 no 2577 0.248071312282348 3638 7593
SGTC_806 3966-4455 5.86 µM -0.682983875292948 0.241266576036411 no 2578 0.247308515838293 3589 714982
SGTC_2796 7949634 45.45 µM -0.684268138887978 0.240861849951295 no 2579 0.246902931058396 3631 2971588
SGTC_2069 5228469 200 µM -0.685097391819706 0.240600713454767 no 2580 0.246641232992176 3616 2835210
SGTC_149 3970-0822 46.1 µM -0.685681308622623 0.240416927226937 no 2581 0.246457047991586 3701 3114250 YBL034C STU1
SGTC_2464 5717415 7.67 µM -0.687749748126765 0.239766507133058 no 2582 0.24580519308362 3604 5285744
SGTC_294 k038-0071 157 µM -0.689419736435459 0.239242081160611 no 2583 0.245279583428537 3659 24152826
SGTC_3225 9130819 49.47 µM -0.690558254866348 0.238884912118939 no 2584 0.244921594483707 3665 4547121
SGTC_2734 clemastine 41.6 µM -0.692153539354583 0.238384940185878 no 2585 0.244420456096431 3644 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2452 5863136 48.41 µM -0.693172968837908 0.23806574507611 no 2586 0.244100504836268 3639 2184096
SGTC_676 falcarinol 140 µM -0.694206548708255 0.237742358611149 no 2587 0.243776343170249 3698 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_524 r073-0010 27.8 µM -0.694764943238573 0.237567748441604 no 2588 0.243601310614318 3612 2772106
SGTC_2350 9023895 38.85 µM -0.696925213431688 0.236892894465089 no 2589 0.242924798900871 3676 2997209
SGTC_1289 0976-0073 69.1 µM -0.697759377478814 0.236632589520492 no 2590 0.242663843792072 3699 3391136
SGTC_3072 9116419 49.47 µM -0.697901806564549 0.236588159565338 no 2591 0.242619302265712 3648 17170162
SGTC_2428 5615643 7.78 µM -0.698988642903474 0.236249278248336 no 2592 0.242279564212403 3687 2253075
SGTC_2354 9060492 162 µM -0.69925423789977 0.236166504986482 no 2593 0.242196580143433 3702 6471895
SGTC_609 0986-0026 86.3 µM -0.699290525987581 0.236155196964999 no 2594 0.242185243275513 3661 2848610
SGTC_446 go6976 132 µM -0.69941341890293 0.236116903535451 no 2595 0.242146852076343 3642 3501 A protein kinase C inhibitor.
SGTC_857 0438-0306 1.35 µM -0.700299855841321 0.235840791155173 no 2596 0.241870030884441 3709 4686136
SGTC_2431 5490079 200 µM -0.70132473778981 0.235521777137787 no 2597 0.241550189493511 3712 5722345
SGTC_777 1315-0167 517 µM -0.70258221809525 0.235130687940797 no 2598 0.241158073643861 3669 4221767
SGTC_732 3970-1727 52.7 µM -0.704049421705173 0.234674826410288 no 2599 0.240700998222937 3679 1275699
SGTC_2321 7390090 138.78 µM -0.704312221860172 0.234593225795552 no 2600 0.240619178360855 3647 649046
SGTC_273 hydroxyurea 18.1 mM -0.70441197636449 0.234562255688594 no 2601 0.24058812488661 3728 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_222 nsc-310342 10.666 µM -0.705031446873002 0.234369983501195 no 2602 0.240395333210419 3639 432556
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.705409924189963 0.234252554079219 no 2603 0.240277584886512 3689 688667
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.706481259090392 0.233920329730723 no 2604 0.239944451631876 3703 1273210
SGTC_3098 9119039 49.47 µM -0.706957323741254 0.233772784389948 no 2605 0.239796499461295 3701 17161528
SGTC_171 k064-0041 9.68 µM -0.707677521618562 0.233549673618511 no 2606 0.239572769791532 3664 53325
SGTC_3106 9121286 49.47 µM -0.709499580686772 0.232985743891336 no 2607 0.239007255805594 3708 15943471
SGTC_2387 9077560 195.08 µM -0.71057221979859 0.232654114612639 no 2608 0.238674681502332 3687 5303272
SGTC_2855 9016525 58.44 µM -0.711821798380508 0.232268111820649 no 2609 0.238287566241319 3710 43811474
SGTC_1062 mesoridazine 14.2 µM -0.711926390963984 0.232235818674117 no 2610 0.238255179414881 3690 4078 A neuroleptic.
SGTC_2210 7115885 190.385 µM -0.712048715688533 0.232198053867292 no 2611 0.238217304935659 3721 2927039
SGTC_1667 st014849 34.6 µM -0.713129578544358 0.231864512097193 no 2612 0.237882788926545 3745 5348460
SGTC_3282 9108498 15.4605 µM -0.713658668878593 0.231701338280665 no 2613 0.23771913482646 3681 16459645
SGTC_1024 4507-0395 26 µM -0.714052494580594 0.23157992223142 no 2614 0.23759735983634 3724 4201836
SGTC_803 4488-1585 147 µM -0.714149642347276 0.231549977131189 no 2615 0.237567326004153 3664 747204
SGTC_936 3005-4620 401 µM -0.714572109707942 0.231419779712439 no 2616 0.237436741844102 3706 777207
SGTC_1050 3232-1156 69.3 µM -0.716102713996845 0.230948414947999 no 2617 0.236963964044795 3684 700529
SGTC_2443 5493264 126.67 µM -0.717345567320223 0.23056606060889 no 2618 0.236580448646874 3724 5340055
SGTC_3158 9100007 49.47 µM -0.719906547476104 0.229779311209863 no 2619 0.235791268224395 3713 19297233
SGTC_2569 tetrandrine 100 µM -0.721890343655258 0.229170911069191 no 2620 0.235180949296036 3724 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.72397451926546 0.228532700389425 no 2621 0.234540689263021 3737 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3316 9136639 10.545 µM -0.725051214852679 0.228203389053266 no 2622 0.234210305801335 3739 4903665
SGTC_120 rhodamine 6G 52.259 µM -0.72865446563675 0.227103263971375 no 2623 0.233106526389775 3752 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2312 7706453 155.7 µM -0.72886968660699 0.227037648627609 no 2624 0.233040689543658 3767 976098
SGTC_2390 9097792 176.6 µM -0.728949664711365 0.22701326808306 no 2625 0.233016226594077 3735 4497149
SGTC_324 1315-0088 19.6 µM -0.729411527073638 0.226872502732611 no 2626 0.232874984383597 3657 6787421
SGTC_928 2764-0428 58.7 µM -0.729502423078341 0.226844805456503 no 2627 0.232847193062674 3765 662578
SGTC_2659 sanguinarine 24.21 µM -0.729705879504999 0.226782816369006 no 2628 0.232784993235603 3676 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1527 coumarin 137 µM -0.730399657910835 0.22657150789769 no 2629 0.232572963708354 3768 323 A hepatotoxic, DNA x-linker.
SGTC_708 3448-5400 146 µM -0.730662285185496 0.22649154685946 no 2630 0.232492728731864 3698 3462195
SGTC_1841 st054148 70 µM -0.730921488631191 0.2264126438858 no 2631 0.232413554860887 3732 675442
SGTC_3327 9140648 26.9345 µM -0.731948892448008 0.226100049188208 no 2632 0.232099881227764 3710 8029710
SGTC_1297 1068-0111 14.1 µM -0.733452693358947 0.225642947488431 no 2633 0.231641185393524 3681 767057
SGTC_25 0118-0223 35.662 µM -0.733501394729208 0.225628152759779 no 2634 0.231626338742106 3749 5333628
SGTC_830 4076-0286 57.8 µM -0.734621387090342 0.225288067766624 no 2635 0.231285054554913 3777 6866659
SGTC_38 0929-0051 58.268 µM -0.735151977351253 0.225127055754127 no 2636 0.231123471007519 3740 1379719
SGTC_907 3448-6986 75.5 µM -0.737273137214652 0.224484023899004 no 2637 0.230478132343419 3758 590582
SGTC_1306 1185-0270 9.02 µM -0.737428408225812 0.224436994302034 no 2638 0.230430932506638 3737 1548076
SGTC_41 0478-0632 82.643 µM -0.737624783822489 0.224377522662272 no 2639 0.230371245290575 3709 3750424
SGTC_2824 7998404 51.95 µM -0.737676398682911 0.22436189277294 no 2640 0.230355558689817 3719 837851
SGTC_1003 4049-0218 100 µM -0.739497697087351 0.223810767316654 no 2641 0.229802418805403 3741 295161
SGTC_2856 9022925 19.48 µM -0.739645975836904 0.223765932020857 no 2642 0.229757418370197 3740 4944862
SGTC_1562 morin hydrate 59.1 µM -0.74100391079438 0.223355568497302 no 2643 0.229345534544807 3775 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1352 1496-0991 99 µM -0.741416135783284 0.223231080231547 no 2644 0.229220581927466 3741 3000039
SGTC_1214 0358-0031 63.7 µM -0.741675147194535 0.223152881306254 no 2645 0.229142090562686 3829 4301366
SGTC_4 0960-0234 25.671 µM -0.742851853029296 0.222797814892341 no 2646 0.228785689015361 3714 6821112
SGTC_2370 9071495 200 µM -0.743593794242375 0.222574102598549 no 2647 0.228561129362517 3731 21791103
SGTC_1483 3453-0561 55.9 µM -0.743663435393177 0.222553110770994 no 2648 0.228540057779673 3743 4546991
SGTC_2929 9013348 24.6 µM -0.745222596995908 0.222083430669935 no 2649 0.228068582231495 3778 2995952
SGTC_1288 0973-0013 65.5 µM -0.745248040431334 0.222075770812814 no 2650 0.228060892918852 3791 4315430
SGTC_1207 2099-0101 141 µM -0.745457475351723 0.222012725247504 no 2651 0.22799760470304 3779 5837381
SGTC_1676 st018489 23.4 µM -0.745676565316654 0.221946784190498 no 2652 0.227931409445684 3797 3696235
SGTC_1903 st060211 78.3 µM -0.749563735914056 0.220778695901025 no 2653 0.226758749314523 3775 688960
SGTC_3032 9089427 49.47 µM -0.750586077200879 0.220472069767697 no 2654 0.226450901386708 3728 17173707
SGTC_2371 9071574 200 µM -0.752574007789401 0.219876538058115 no 2655 0.225852970850878 3732 45596039
SGTC_1242 0402-0103 60.1 µM -0.75484262828805 0.219198048351065 no 2656 0.225171706456081 3718 432868
SGTC_2175 5807670 165.306 µM -0.756152331022326 0.218806896452223 no 2657 0.224778934693929 3714 241186
SGTC_2630 antimycin a 100 µM -0.760084329482422 0.21763499339936 no 2658 0.223602089489982 3775 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1660 st012960 28.1 µM -0.760133202909379 0.217620449861841 no 2659 0.223587483778768 3768 24207266
SGTC_1939 st074455 53.6 µM -0.764356340666581 0.216365866825939 no 2660 0.22232745948002 3768 1644229
SGTC_1142 3253-1408 9.78 µM -0.771645538892346 0.214210315565179 no 2661 0.220162197428263 3742 256655
SGTC_3277 9138724 49.47 µM -0.771931501842164 0.214126006484023 no 2662 0.220077499176452 3739 15943418
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.773607737860505 0.213632198355914 no 2663 0.219581397414713 3800 5106787 A p450 inhibitor.
SGTC_310 1273-0058 1.06 µM -0.773681537261178 0.21361047279584 no 2664 0.219559570385701 3758 2734232
SGTC_1241 0364-0022 50.8 µM -0.7743262163424 0.213420742610758 no 2665 0.219368952065785 3824 4563895
SGTC_1504 k297-0033 30 µM -0.774646321013041 0.213326571751767 no 2666 0.219274339053899 3706 4388117
SGTC_722 3534-0461 190 µM -0.775051325928811 0.213207459007238 no 2667 0.219154665779133 3820 658262
SGTC_1494 4358-1428 177 µM -0.775571956524545 0.213054397513126 no 2668 0.219000881912571 3818 1564571
SGTC_624 k048-0052 28 µM -0.777405492234053 0.212515862432792 no 2669 0.218459786565769 3780 6835531
SGTC_2496 diffractaic acid 79.83 µM -0.777991679133429 0.21234385903102 no 2670 0.218286959306264 3814 94870 An apoptosis inducer which activates caspases.
SGTC_3179 9107801 49.47 µM -0.778140534547269 0.212300193703467 no 2671 0.218243084358508 3794 4818259
SGTC_725 1497-0963 19 µM -0.780600548045808 0.21157933232733 no 2672 0.217518734675325 3835 3549977
SGTC_229 benomyl 22.8748 µM -0.781633382991989 0.211277106798431 no 2673 0.217215031062545 3816 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_2394 5221648 200 µM -0.782257377237319 0.211094637815803 no 2674 0.217031665216143 3884 788586
SGTC_57 miconazole 162.5 nM -0.782513782213751 0.211019686414048 no 2675 0.216956344440494 3723 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1085 doxorubicin 7.67 µM -0.786329265738218 0.209906202206252 no 2676 0.215837305677472 3803 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1915 st067105 30.6 µM -0.78805358612695 0.209404123593002 no 2677 0.215332681210223 3795 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_278 4092-0821 23.9 µM -0.788670461594717 0.209224676778643 no 2678 0.215152318245913 3826 877900
SGTC_2349 9023730 187.07 µM -0.788795580694112 0.209188291136215 no 2679 0.215115746438436 3789 4126287
SGTC_1139 k015-0024 46.9 µM -0.789237585379992 0.209059782440167 no 2680 0.21498657915138 3796 2766652
SGTC_3153 9100258 49.47 µM -0.791660927387306 0.208356045216397 no 2681 0.214279205362914 3752 25236848
SGTC_2414 st077232 92.9 µM -0.792851559941159 0.208010798699962 no 2682 0.213932156193076 3797 729801
SGTC_807 1315-0151 48 µM -0.792979955245777 0.207973588227037 no 2683 0.213894750699174 3799 4011080
SGTC_3011 9081274 71.4286 µM -0.793718535552882 0.207759615282221 no 2684 0.213679653549422 3817 6625322
SGTC_1169 aniline yellow 25.8 µM -0.793935087340686 0.20769690306376 no 2685 0.213616610949554 3765 6051 A DNA damaging agent.
SGTC_2686 alizarin 95.37 µM -0.797894436273013 0.206552269854417 no 2686 0.212465876173456 3847 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1101 ebselen 5.29 µM -0.798781947018667 0.206296207356195 no 2687 0.212208430132147 3836 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2051 5263410 176 µM -0.800467851228657 0.205810312725035 no 2688 0.211719891399912 3870 227584
SGTC_1116 jasmonic acid 1.58368 µM -0.800648701875044 0.205758230099985 no 2689 0.211667523897196 3858 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2286 7945697 125 µM -0.802561743856468 0.205207778090066 no 2690 0.211114043763053 3858 1245733
SGTC_1260 0700-1617 7.75 µM -0.804403893465497 0.204678552222026 no 2691 0.210581876666533 3865 2853078
SGTC_1088 bifonazole 369 nM -0.804649125007255 0.204608161646361 no 2692 0.210511092676438 3767 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_511 blebbistatin 171 µM -0.805297020977897 0.204422260707131 no 2693 0.210324150232912 3899 3476986 A myosin inhibitor.
SGTC_2765 myclobutanil 7.74 µM -0.805829418620031 0.204269575007838 no 2694 0.21017060640197 3872 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2077 5212015 200 µM -0.810816213986934 0.202842717548942 no 2695 0.208735610903315 3732 780900
SGTC_2982 9019404 25.97 µM -0.811024577504297 0.202783228967699 no 2696 0.208675778357579 3803 22333232
SGTC_2257 7960413 200 µM -0.813630446372936 0.202040124164291 no 2697 0.207928345248832 3836 2974689 YIL048W NEO1
SGTC_2307 7538926 6.34 µM -0.815916849551005 0.201389464269871 no 2698 0.20727384724068 3887 96582
SGTC_2650 prasterone 100 µM -0.816747569824363 0.201153371007159 no 2699 0.207036350133617 3813 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_805 3852-0218 479 µM -0.817779063174832 0.200860448527215 no 2700 0.206741677603061 3799 6615355
SGTC_935 2996-0153 430 µM -0.817923890127658 0.200819341212107 no 2701 0.206700323958847 3830 23738523
SGTC_452 diindolylmethane 8 µM -0.818868309753958 0.200551403370625 no 2702 0.206430776101441 3867 3071 Inhibits expression of several cancer promoting factors.
SGTC_1934 st074720 32.6 µM -0.819247192894674 0.200443972183105 no 2703 0.206322697204622 3807 17250992
SGTC_646 4092-0839 27.3 µM -0.820602856958755 0.200059860867588 no 2704 0.205936259909981 3911 877796
SGTC_2123 5259487 200 µM -0.820633546262537 0.20005117054286 no 2705 0.205927516777497 3862 2173474
SGTC_2397 5161689 200 µM -0.821275133118211 0.199869543639453 no 2706 0.205744784335603 3875 2259942
SGTC_308 4092-1169 104 µM -0.822368038675889 0.19956038131674 no 2707 0.205433732003315 3810 2268590 YDL196W YDL196W
SGTC_2911 7942208 15.64 µM -0.823328009610932 0.199289061255036 no 2708 0.205160744770736 3896 1243384
SGTC_2072 5231554 129 µM -0.825873146030599 0.198570796128757 no 2709 0.204438027674185 3916 789545
SGTC_1076 itraconazole 331 nM -0.830233557121279 0.197343875833317 no 2710 0.203203372918408 3876 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1042 0350-0096 82 µM -0.832759161168196 0.196635330126869 no 2711 0.202490285637357 3880 3122515
SGTC_3036 9090181 49.47 µM -0.832971119114689 0.196575936550744 no 2712 0.20243050886372 3896 25236586
SGTC_503 tyrphostin 8 294 µM -0.833130954743729 0.196531155565021 no 2713 0.202385438702217 3833 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.833858447296776 0.196327412819988 no 2714 0.202180377493356 3971 688801
SGTC_3148 9097893 49.47 µM -0.834700080309379 0.196091863528989 no 2715 0.201943298218082 3900 17174100
SGTC_1171 0368-0077 21.4 µM -0.834889630666496 0.196038837400009 no 2716 0.201889926821018 3837 3239779
SGTC_950 1165-0508 94.1 µM -0.83502570996402 0.196000774999401 no 2717 0.201851616394315 3904 6148369
SGTC_3020 9089140 49.47 µM -0.83735724060393 0.19534932503332 no 2718 0.201195896593446 3949 17217859
SGTC_458 nppb 133 µM -0.837896947050912 0.195198714049498 no 2719 0.201044291773876 3882 4549 A chloride channel blocker.
SGTC_1705 st027868 56.3335 µM -0.838648340104943 0.194989147153795 no 2720 0.200833337829536 3858 292948
SGTC_2560 caryophyllene 100 µM -0.839270022193558 0.194815860681623 no 2721 0.200658900757355 3936 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2343 7990716 14.84 µM -0.841002701532402 0.194333391517215 no 2722 0.200173210487006 3883 6456862
SGTC_2236 dapsone 200 µM -0.841256713528353 0.194262722397394 no 2723 0.200102067385157 3891 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2864 9034755 47.6 µM -0.841293279261858 0.194252550669704 no 2724 0.200091827389291 3851 4930451
SGTC_288 1315-0019 35.1 µM -0.842180274126567 0.194005908915377 no 2725 0.199843526754414 3955 6811474
SGTC_659 k018-0002 107 µM -0.843800752553642 0.193555804462137 no 2726 0.199390377458688 3878 6797879 YHR007C ERG11
SGTC_221 trifluoperazine 10.304 µM -0.84436959504615 0.193397953795873 no 2727 0.199231453609139 3864 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2620 irigenin 100 µM -0.846374878671892 0.19284212536336 no 2728 0.198671824030292 3945 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_3016 9080866 49.47 µM -0.846959613037514 0.192680231494367 no 2729 0.198508816496649 3897 17066299
SGTC_334 1502-1024 68.5 µM -0.847922628826711 0.192413784936395 no 2730 0.198240530641252 3954 3296216
SGTC_2787 5284540 71.43 µM -0.84878584303594 0.192175142991206 no 2731 0.19800023454959 3943 736958
SGTC_2219 9098279 200 µM -0.849246025047301 0.192047996301101 no 2732 0.197872203920597 3857 902349
SGTC_439 amiodarone 34.4 µM -0.849634766424693 0.191940628530418 no 2733 0.197764088295738 3795 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1714 st033236 13.627 µM -0.849972284102285 0.191847438207312 no 2734 0.197670247814117 3918 2916566
SGTC_476 mead acid 10 µM -0.85211460952889 0.191256577533628 no 2735 0.197075242042395 3911 5312531 An omega 9 fatty acid.
SGTC_729 4092-0585 94.1 µM -0.853283038415811 0.190934791481851 no 2736 0.196751181906636 3919 2169061
SGTC_1329 1447-1697 50.6 µM -0.854705329646666 0.190543540062959 no 2737 0.196357149638846 3927 2840515
SGTC_2922 7999257 32.47 µM -0.855237415317592 0.190397297717558 no 2738 0.196209863391867 3876 2988377
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.858047288366423 0.189626155259573 no 2739 0.195433176030786 3954 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2854 9024559 71.43 µM -0.859956090416492 0.189103400564853 no 2740 0.194906623762752 3968 3163529
SGTC_504 lovastatin 124 µM -0.861923019950976 0.188565656240729 no 2741 0.194364940220718 3942 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1382 3002-2117 298 µM -0.863541704750254 0.188123827493629 no 2742 0.193919849948479 3972 1497314
SGTC_2161 5662504 8.5105 µM -0.86459278295814 0.187837272457846 no 2743 0.193631167544655 3890 2859334
SGTC_2215 7188065 200 µM -0.864923803777672 0.18774708222559 no 2744 0.193540305779716 3933 940217
SGTC_658 3253-0951 102 µM -0.865694151220279 0.187537296241878 no 2745 0.193328954140153 3919 1184878
SGTC_1175 0741-0056 27.6 µM -0.866430016749911 0.187337035926456 no 2746 0.193127194499283 4027 765927
SGTC_1522 st012842 45.6 µM -0.866964355659706 0.187191702462477 no 2747 0.192980770025569 3804 3491067 YOR116C RPO31
SGTC_2803 7707263 71.43 µM -0.867225986467563 0.187120567607385 no 2748 0.192909100270829 3895 2199229
SGTC_913 3487-1245 167 µM -0.867710089908039 0.186988988718288 no 2749 0.19277653042172 3887 4016153
SGTC_2021 4019055 173 µM -0.873658787523051 0.185376814577601 no 2750 0.191152050491583 3859 44827708 YER133W GLC7
SGTC_2790 5423970 71.43 µM -0.87434941256699 0.185190206922736 no 2751 0.190963998791214 4012 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1208 2323-2347 50.3 µM -0.876363399969115 0.184646691779607 no 2752 0.190416254351985 3947 5412760
SGTC_1581 himbacine 57.9 µM -0.880104613463248 0.183639685610221 no 2753 0.18940132006287 3930 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2056 5235370 200 µM -0.881371540845651 0.183299449388597 no 2754 0.189058377994644 3915 5511916
SGTC_2405 ticlatone 3.52 µM -0.881724236308983 0.183204802211631 no 2755 0.188962975655242 3822 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2486 5283202 22.39 µM -0.881899624636488 0.183157747432425 no 2756 0.188915545042627 4005 1377751
SGTC_2110 5483698 200 µM -0.882612468855182 0.182966576682306 no 2757 0.188722844670694 3941 2848765 YHR062C RPP1
SGTC_654 1124-0271 80.9 µM -0.882793403616526 0.182918073369967 no 2758 0.18867395257401 3945 5403748
SGTC_3088 9117578 49.47 µM -0.883607239402296 0.182700007054319 no 2759 0.188454134852346 3986 678341
SGTC_3332 9141069 11.198 µM -0.883998758462738 0.182595157844713 no 2760 0.188348441521596 3878 17332883
SGTC_1213 1315-0166 115 µM -0.884371947128777 0.182495252520405 no 2761 0.188247730655923 4043 768401
SGTC_3320 9137005 35.139 µM -0.884759792083591 0.182391459789668 no 2762 0.188143099775148 3968 4908713
SGTC_834 0312-0008 75.7 µM -0.884767304369985 0.182389449760995 no 2763 0.18814107350231 3941 6385573 YIL048W NEO1
SGTC_1701 st028638 40.4 µM -0.885989914828135 0.182062505805419 no 2764 0.187811480889976 3909 3490878
SGTC_960 1222-0186 7.7 µM -0.887125313314805 0.181759211963574 no 2765 0.187505718526091 4011 3126296
SGTC_3052 9092717 49.47 µM -0.8876824229783 0.18161050945431 no 2766 0.187355801683987 3976 25237534
SGTC_924 2046-0044 21.3 µM -0.888883926494094 0.181290065971976 no 2767 0.18703273235656 3954 3623589
SGTC_3029 9088683 49.47 µM -0.889383382043722 0.181156964387419 no 2768 0.18689853644733 3971 25236615
SGTC_336 4111-0029 111 µM -0.89005155258161 0.180978997128134 no 2769 0.186719102651526 3951 3131175
SGTC_3241 9133421 49.47 µM -0.890540781487569 0.180848760481638 no 2770 0.186587790368993 3956 17018221
SGTC_2101 5377231 179.231 µM -0.890662624521236 0.180816334031156 no 2771 0.186555095786962 3989 2844213
SGTC_1757 st041620 31.8375 µM -0.890811265126634 0.18077678079823 no 2772 0.186515215319684 4039 5289815
SGTC_2358 9037157 4 µM -0.891146698404786 0.180687542008598 no 2773 0.186425237539175 3958 2388925
SGTC_745 0469-0705 296 µM -0.891276112661414 0.180653119978608 no 2774 0.186390530201227 4039 3486736
SGTC_3028 9087778 49.47 µM -0.892533128625199 0.180318988707152 no 2775 0.186053622019452 3937 17217395
SGTC_40 0327-0103 19.753 µM -0.893417539221395 0.180084133372797 no 2776 0.185816806742086 3850 409036
SGTC_918 glabranin 770.725 nM -0.895159665442206 0.179622073566555 no 2777 0.185350871340393 3988 124049 Also referred to as licorice root.
SGTC_723 4182-0001 115 µM -0.897009292246509 0.179132317828297 no 2778 0.184856979319348 3978 744821 YLR208W SEC13
SGTC_2240 6690706 185.951 µM -0.897144738979294 0.179096486435991 no 2779 0.184820844160245 3822 805876
SGTC_3089 9117425 49.47 µM -0.898469710143755 0.178746213320383 no 2780 0.184467593277006 3956 9401657
SGTC_2845 9003024 42.97 µM -0.899006045086227 0.178604549010322 no 2781 0.184324720375164 4037 2990173
SGTC_2022 5136654 200 µM -0.899223091588502 0.178547239744889 no 2782 0.184266921484103 4027 1713771
SGTC_736 0958-0254 92.6 µM -0.899509756377055 0.17847156612093 no 2783 0.184190600720464 4058 6812352
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.899661964121211 0.17843139461138 no 2784 0.18415008539001 3996 688664
SGTC_2445 5742597 35.57 µM -0.899838562444953 0.178384792944463 no 2785 0.184103084619533 3933 1774255
SGTC_1761 st044296 37 µM -0.90044354142335 0.178225206142516 no 2786 0.183942129073029 3956 1826700
SGTC_526 4469-0568 170 µM -0.901125009391981 0.178045550186938 no 2787 0.183760928499913 3915 2901964
SGTC_2827 7993847 71.43 µM -0.901702680756457 0.177893347665349 no 2788 0.183607414289681 4053 2985692
SGTC_853 0419-0306 21 µM -0.902023914860695 0.177808745713163 no 2789 0.183522082000802 3994 762713
SGTC_1166 k206-0078 225 µM -0.903810406613629 0.177338708750212 no 2790 0.183047971317374 3991 5404595
SGTC_1356 1502-0781 85.8 µM -0.905426871520044 0.176914083658439 no 2791 0.182619642616611 3932 567702
SGTC_552 k242-0005 476 µM -0.906419401657372 0.176653677079817 no 2792 0.18235695370883 4059 4088318
SGTC_3067 9117431 49.47 µM -0.906700678647873 0.176579923540387 no 2793 0.182282552229274 4028 17150885
SGTC_1612 st002233 45.4 µM -0.908610984780804 0.176079538205021 no 2794 0.181777753056348 3975 1035021
SGTC_35 0133-0054 64.071 µM -0.911893610352472 0.175221786615978 no 2795 0.18091236274899 3990 99677
SGTC_2913 7966556 36.57 µM -0.913531301633747 0.174794849615715 no 2796 0.180481589344524 3842 2976516
SGTC_202 3594-0513 34.79 µM -0.91469422158284 0.17449208411968 no 2797 0.18017608936676 3983 708429
SGTC_2411 st077133 39.94 µM -0.917601123831354 0.173736731842495 no 2798 0.179413864658555 4094 1403142 YNL221C POP1
SGTC_1384 3089-0840 101 µM -0.918511410317561 0.173500624164507 no 2799 0.179175594017099 3979 1069836
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.919051981788444 0.17336050887082 no 2800 0.17903419180158 4054 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1510 1123-0200 71.5 µM -0.919935403756587 0.173131682360581 no 2801 0.178803258229407 4059 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_842 0271-0008 11.1 µM -0.921128356335469 0.172822985776338 no 2802 0.178491708597191 4051 1221709
SGTC_1224 0823-0416 294 µM -0.923291694108804 0.172264081142653 no 2803 0.17792760757899 4081 3598164
SGTC_1881 5652484 16 µM -0.925039067924088 0.171813484951521 no 2804 0.177472792969027 3971 2255129
SGTC_1884 5633444 25 µM -0.925470183682103 0.171702428778642 no 2805 0.177360693113811 4011 5724239
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.926008954507494 0.171563704947594 no 2806 0.177220663365795 3916 1241132 A phosphatase inhibitor.
SGTC_1063 disulfiram 1.84 µM -0.927782182712315 0.171107636365927 no 2807 0.176760284045186 3991 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_157 1348-1695 65.819 µM -0.927902132433813 0.171076813708612 no 2808 0.176729169089323 3961 5380510
SGTC_3137 9097352 49.47 µM -0.929280447201277 0.170722892495146 no 2809 0.176371882792228 4016 44120435
SGTC_1098 clofazimine 15.1 µM -0.930437110252924 0.170426248539997 no 2810 0.17607240590483 4075 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.931309123946305 0.17020282565769 no 2811 0.175846841842286 4048 5282309
SGTC_2024 5144227 134 µM -0.931785600264929 0.170080824660991 no 2812 0.175723668919435 4082 3475211
SGTC_906 1165-0455 526 µM -0.932510665167452 0.169895280520352 no 2813 0.175536338770066 3985 3252859
SGTC_602 3130-1533 38.1 µM -0.932859140507925 0.169806151856916 no 2814 0.175446350586248 4040 720941
SGTC_113 0099-0221 2.5 µM -0.934112432920755 0.169485848289628 no 2815 0.175122949631543 3936 89219
SGTC_127 0180-0333 59.125 µM -0.936098002203373 0.168979191139919 no 2816 0.174611365779042 3890 771601
SGTC_883 0850-0245 24.6 µM -0.936686371582722 0.168829244138797 no 2817 0.174459954286283 4091 6823229 YPR165W RHO1
SGTC_1117 retinoic acid 1.10837 µM -0.936862041350878 0.168784490959067 no 2818 0.174414763445673 4058 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2389 9091542 195.52 µM -0.937454215950253 0.168633686242606 no 2819 0.174262482017701 4001 3626624 YOL127W RPL25
SGTC_1228 0124-0032 52.5 µM -0.93899013597443 0.168242948648001 no 2820 0.173867904398596 4086 X1228
SGTC_2857 9024691 58.44 µM -0.939349351433338 0.168151648444382 no 2821 0.173775704047829 4114 16478292
SGTC_1863 st057641 20.1 µM -0.940086038456144 0.167964507709553 no 2822 0.173586714836733 4033 3921635
SGTC_1258 0671-0043 57.1 µM -0.940295308337513 0.167911371303205 no 2823 0.173533052739241 4047 4298767
SGTC_1322 1348-1070 12 µM -0.943859096633228 0.16700813958965 no 2824 0.172620828290731 3996 6758089
SGTC_2987 9018338 71.43 µM -0.944621819794 0.166815237446297 no 2825 0.172425991628449 4066 5055682
SGTC_1440 4100-1550 40 µM -0.945756570351672 0.166528511086179 no 2826 0.172136380731723 4026 742806
SGTC_2488 5268135 45.7 µM -0.947269451165904 0.166146734688015 no 2827 0.171750746646809 4084 1270356 YLR208W SEC13
SGTC_3324 9138759 60.749 µM -0.948375843966785 0.165867894021982 no 2828 0.171469076174564 4066 45595710
SGTC_1600 coumarin 106 71.1 µM -0.948860719694605 0.16574578771574 no 2829 0.171345727417021 4093 100336 A hepatotoxic, DNA x-linker.
SGTC_788 1182-0090 188 µM -0.948977343721689 0.165716426947022 no 2830 0.171316067601431 4085 5715185
SGTC_497 capsazepine 133 µM -0.951525275491651 0.165075809866961 no 2831 0.170668897024056 3999 2733484 A calcium channel blocker.
SGTC_726 3448-4391 34.2 µM -0.952516130998416 0.164827116274762 no 2832 0.170417644508503 4153 1356692
SGTC_1028 k015-0029 4.8 µM -0.955343106971517 0.164118911722431 no 2833 0.169702107417873 3985 4588309
SGTC_1914 st062367 72.6 µM -0.956022115215141 0.163949103252949 no 2834 0.169530530767643 4033 978205
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.956870261913685 0.163737156309559 no 2835 0.169316371405065 4029 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2814 7977482 42.97 µM -0.956903814216546 0.163728775442354 no 2836 0.169307902929044 4112 6456762
SGTC_1683 st010134 710 nM -0.958441578053197 0.163344963718389 no 2837 0.168920068876618 4033 3818134
SGTC_1821 st053465 65.6 µM -0.959662051240959 0.163040761200026 no 2838 0.168612664154772 4043 675086
SGTC_1695 st026914 34.495 µM -0.960670251492722 0.162789745569522 no 2839 0.168358996735591 4008 3289191
SGTC_896 0964-0007 44.5 µM -0.962271920381455 0.162391488768665 no 2840 0.167956515066072 3985 6756758
SGTC_2377 9073351 62.6 µM -0.962341856417795 0.162374113554737 no 2841 0.167938955036877 4014 7337946 YHR072W ERG7
SGTC_1040 k898-0338 155 µM -0.963159639569228 0.162171029747043 no 2842 0.167733708029307 4066 20969351
SGTC_3082 9117008 49.47 µM -0.966717242972167 0.161289479591161 no 2843 0.166842702415103 4122 41448529
SGTC_899 1083-0020 478 µM -0.966843977189186 0.161258133472778 no 2844 0.166811018117738 4117 767123
SGTC_399 oxolinic acid 75 µM -0.966904009879034 0.16124328652736 no 2845 0.166796010948266 4014 4628 A DNA gyrase inhibitor.
SGTC_1244 0416-0015 52.5 µM -0.966984670932402 0.161223339295746 no 2846 0.166775848404043 4016 96201
SGTC_545 4218-0007 221 µM -0.967154233274651 0.161181412296744 no 2847 0.166733468662079 4067 2840508
SGTC_2276 7947513 42.08 µM -0.967974562290156 0.160978673303318 no 2848 0.166528537007493 4007 2105100
SGTC_277 nystatin 15.5 µM -0.969513576242233 0.160598765236452 no 2849 0.166144504914604 4042 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_111 0083-0039 52.457 µM -0.969939085367327 0.160493831049707 no 2850 0.166038428122951 3941 759313
SGTC_908 3448-7491 47.7 µM -0.974525708235719 0.159365575023517 no 2851 0.164897790417394 4061 1203031
SGTC_1531 st059297 52.4 µM -0.976911581291842 0.158780736263121 no 2852 0.164306463859548 4069 7566702
SGTC_2817 7995342 71.43 µM -0.978143883263554 0.158479219090302 no 2853 0.164001583190427 4063 18879975
SGTC_1153 4055-0057 267 µM -0.979870235358239 0.158057450716209 no 2854 0.163575088509251 4112 882706
SGTC_1491 4138-0063 26.5 µM -0.9799750101374 0.158031876728949 no 2855 0.163549227138474 4024 23883227
SGTC_548 1436-0017 110 µM -0.981302406282227 0.15770811401665 no 2856 0.163221818240464 4153 9677137
SGTC_2087 5276107 200 µM -0.981607545494372 0.157633749719034 no 2857 0.163146614374589 4026 144405
SGTC_2842 9000675 19.48 µM -0.981969807070665 0.15754549426591 no 2858 0.163057361511329 4128 2989072
SGTC_3289 9119912 71.43 µM -0.983124379409614 0.157264429936934 no 2859 0.162773113437939 4124 17014829
SGTC_2126 5251174 33.877 µM -0.985559893954217 0.156672620168904 no 2860 0.162174563438214 4102 790722
SGTC_381 3461-2219 42.7 µM -0.987731939152336 0.156146069482114 no 2861 0.161641973985635 4083 2883159
SGTC_2543 pimpinellin 60.67 µM -0.98796930944766 0.156088596553194 no 2862 0.161583839538148 3902 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1573 oleylamine 1.06 µM -0.990638974035859 0.155443168141032 no 2863 0.160930949814089 4066 5356789 An amine of the fatty acid oleic acid.
SGTC_2572 astragaloside iv 100 µM -0.99095742807942 0.155366295186373 no 2864 0.160853184219574 4140 45006101 An anti-inflammatory agent.
SGTC_3077 9117319 49.47 µM -0.99588245155597 0.154180617739126 no 2865 0.159653631316557 4055 17154678
SGTC_2614 arthonioic acid 13.39 µM -0.999346322475834 0.153350300524367 no 2866 0.158813476451934 3963 6710684
SGTC_1801 st050089 28.441 µM -1.00157924265285 0.152816625133994 no 2867 0.158273425180813 4126 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1271 0832-2808 169 µM -1.003794011163 0.152288506181822 no 2868 0.157738955823639 4127 3663794
SGTC_477 mead ethanolamide 10 µM -1.00458470967278 0.152100255322939 no 2869 0.157548431460743 3999 16061185
SGTC_1124 fisetin 1.16336 µM -1.008819130036 0.151094747974887 no 2870 0.15653069241038 4118 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1636 st007707 68.9 µM -1.01029954592378 0.150744253600653 no 2871 0.156175899321036 4145 403051
SGTC_1771 st048882 4.1505 µM -1.0106621087062 0.150658498003776 no 2872 0.156089089186869 4120 4580403
SGTC_2830 7992007 71.43 µM -1.01277382520272 0.150159667485056 no 2873 0.155584102912187 3987 1952075
SGTC_1371 2421-0008 32.7 µM -1.01676854461356 0.149219047608448 no 2874 0.154631774612103 4074 2827552
SGTC_944 3370-0224 231 µM -1.01715139317926 0.149129106923757 no 2875 0.154540707457318 4146 4580514
SGTC_1335 1486-0900 202 µM -1.01729699611464 0.149094910665198 no 2876 0.15450608258656 4097 X1335
SGTC_2475 5812728 15.03 µM -1.01742481226281 0.149064896122996 no 2877 0.154475691700857 4047 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_116 0155-0182 31.788 µM -1.0198902055791 0.14848674765284 no 2878 0.153890267595963 4018 771486
SGTC_2690 usnic acid 100 µM -1.02154585386373 0.148099331623554 no 2879 0.153497948022002 4154 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_876 0720-0963 56.8 µM -1.02310949623427 0.147734066296473 no 2880 0.153128038749753 4135 765861
SGTC_106 0092-0003 11.579 µM -1.02317276754766 0.147719298890194 no 2881 0.15311308316757 4021 1072148
SGTC_2598 perillyl alcohol 100 µM -1.02320523379851 0.147711721711716 no 2882 0.153105409422928 4158 10819 An apoptosis inducer.
SGTC_2704 st078022 71.1 µM -1.02374685795168 0.147585352441455 no 2883 0.152977428376816 4177 54697681
SGTC_2318 6029776 164 µM -1.02496828453831 0.147300640648301 no 2884 0.15268907635236 4161 818325
SGTC_3224 9130643 49.47 µM -1.02531222232294 0.147220535990536 no 2885 0.152607945283593 4180 17644395
SGTC_538 2922-0838 53.3 µM -1.02583164753076 0.147099614882615 no 2886 0.152485472920008 4120 777039
SGTC_3330 9141424 71.43 µM -1.02654359798 0.146933982517363 no 2887 0.152317712101672 4200 27261020
SGTC_2398 5228213 48.84 µM -1.02661397865337 0.146917615537573 no 2888 0.152301134571705 4138 80771 YMR134W ERG29
SGTC_1762 st045503 25.4615 µM -1.02704784568489 0.146816747045602 no 2889 0.152198967573243 4206 4645554
SGTC_181 1447-1644 8.07 µM -1.02879345276188 0.146411385462246 no 2890 0.151788372004369 4125 534600
SGTC_467 ro 31-8220 72.8 µM -1.02934361218537 0.146283784350879 no 2891 0.151659118123061 4061 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_810 3825-7150 143 µM -1.0298204273428 0.146173254752284 no 2892 0.151547154860481 4193 22330411 YGL099W LSG1
SGTC_1829 berberine 14.4 µM -1.03001444887757 0.146128295056454 no 2893 0.151501611463142 4115 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3078 9116413 49.47 µM -1.03024553888611 0.146074757779608 no 2894 0.151447378719797 4056 17177322
SGTC_567 1080-0542 68.4 µM -1.03346517783896 0.145330225601366 no 2895 0.150693129185752 3989 5950415
SGTC_2960 9079389 5.97 µM -1.03492344945631 0.144993845981377 no 2896 0.150352331254908 4129 16457355
SGTC_1122 capsaicin 818.572 nM -1.03494436199404 0.144989025899821 no 2897 0.150347447735049 4194 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1664 st014217 9.02 µM -1.03513908695294 0.14494414938109 no 2898 0.150301980412737 4171 3982782
SGTC_2325 6158266 200 µM -1.03635965945023 0.144663067985045 no 2899 0.150017191463487 4150 3623240
SGTC_1402 3909-7673 35.9 µM -1.04174761723757 0.143426683585541 no 2900 0.148764352990493 4142 5328014
SGTC_1150 3909-7983 10.9 µM -1.0418530919664 0.143402551521904 no 2901 0.148739897399397 4105 23965914
SGTC_1001 4048-4355 44.4 µM -1.04294440814139 0.143153025044929 no 2902 0.148487020289065 4114 21824233
SGTC_1608 st001473 40.5 µM -1.04477182068992 0.142735849242335 no 2903 0.148064220846664 4106 7292267
SGTC_3347 9188721 44.724 µM -1.04550122362357 0.142569565249414 no 2904 0.147895687675111 4159 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2933 9026794 32.47 µM -1.04556299620514 0.142555488803535 no 2905 0.147881420629538 4092 17586027
SGTC_2895 9054447 58.44 µM -1.04931697126539 0.141701814469647 no 2906 0.147016128789225 4198 2697450
SGTC_95 0471-0001 561.058 µM -1.05026967657841 0.141485716148741 no 2907 0.146797071323781 4140 4015405
SGTC_2466 5983409 37.09 µM -1.05146184280309 0.141215616586754 no 2908 0.146523262719258 4153 2879657
SGTC_372 0155-0182 15.9 µM -1.05284445283114 0.140902807768462 no 2909 0.146206143855347 4051 771486
SGTC_3247 9135149 49.47 µM -1.05573741362321 0.140249811098405 no 2910 0.145544099489267 4154 8934436 YOR116C RPO31
SGTC_2727 riluzole 51.77 µM -1.05960634590805 0.139379736095996 no 2911 0.144661862698042 4169 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_3120 9124077 49.47 µM -1.06088716620499 0.139092506233811 no 2912 0.144370591177607 4270 18774327 YGL155W CDC43
SGTC_550 4123-0385 25.7 µM -1.06243137952526 0.138746745314461 no 2913 0.14401994728572 4176 5731123
SGTC_1414 3917-0015 5.4 µM -1.06322237455511 0.138569862532377 no 2914 0.143840558996633 4129 6618702
SGTC_169 k015-0017 16.025 µM -1.06446620612124 0.138292027047378 no 2915 0.143558777762222 4115 1840002
SGTC_326 k292-0812 17.5 µM -1.06742577267675 0.137632474265919 no 2916 0.142889807777654 4139 3579357
SGTC_2137 5261020 140 µM -1.07131497594302 0.136769016938211 no 2917 0.142013914146178 4118 763655
SGTC_1019 4262-0212 3.4 µM -1.07591465414134 0.135752613286171 no 2918 0.140982713746751 4192 4677213
SGTC_130 0136-0219 337.655 µM -1.07595538905238 0.135743635151762 no 2919 0.140973604146124 4004 234244
SGTC_1231 0242-0792 125 µM -1.07645758110038 0.135632983464047 no 2920 0.140861331092675 4161 3707635
SGTC_3166 9102297 49.47 µM -1.08001772001003 0.13485032356418 no 2921 0.140067144704292 4165 25237072
SGTC_235 0330-0087 5 mM -1.08072296038489 0.13469565214288 no 2922 0.139910183269606 4198 46494818 YHR062C RPP1
SGTC_2725 haloperidol 53.21 µM -1.08141323027245 0.134544381946615 no 2923 0.139756669538073 4105 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2040 5100729 123 µM -1.08473824529802 0.133817350782596 no 2924 0.139018801873907 4202 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2678 equilin 100 µM -1.08488119167106 0.133786155501072 no 2925 0.138987139629257 4186 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2610 ononetin 44.17 µM -1.08671135695879 0.133387199014255 no 2926 0.138582196644008 4170 259632
SGTC_656 4090-1979 187 µM -1.08671240159552 0.133386971528556 no 2927 0.138581965737112 4236 22330961
SGTC_570 0987-0065 62.6 µM -1.08764238846754 0.133184558467091 no 2928 0.138376505073193 3958 3104428
SGTC_510 ag-490 170 µM -1.08870038083521 0.132954541953044 no 2929 0.13814301690771 4299 5328779
SGTC_972 1319-0219 195 µM -1.08949697901679 0.132781535333843 no 2930 0.137967393163014 4158 23903702
SGTC_2451 5856223 45.7 µM -1.09033690305112 0.132599287110848 no 2931 0.137782382501066 4148 2179896
SGTC_21 0849-0113 22.993 µM -1.09086299141082 0.132485223325881 no 2932 0.137666586905522 4148 1560156
SGTC_1942 st076330 65.2 µM -1.09136295239146 0.132376887018248 no 2933 0.137556603690141 4266 24208414
SGTC_2320 7373003 200 µM -1.09769894084384 0.131009233397715 no 2934 0.136167986210246 4242 5415828
SGTC_2206 7254556 146.969 µM -1.09884021817743 0.130763924566746 no 2935 0.13591888312057 4191 4398905
SGTC_1731 st035964 63 µM -1.09965991809755 0.130587932371079 no 2936 0.135740162387215 4119 6739575
SGTC_3191 9110352 49.47 µM -1.10030111454773 0.130450379655333 no 2937 0.135600473350373 4142 17122424
SGTC_2341 7987486 176.74 µM -1.10050236149601 0.13040722780799 no 2938 0.135556650638145 4225 1258686
SGTC_3283 9109332 35.8195 µM -1.10053302130223 0.130400654526487 no 2939 0.135549975136026 4035 17027281
SGTC_2656 pseudo-anisatin 100 µM -1.10073159500388 0.130358087045696 no 2940 0.135506745509801 4219 6708809 A neurotoxin.
SGTC_2700 st077718 96.8 µM -1.10426295619631 0.129602687889877 no 2941 0.13473954350252 4187 904970
SGTC_2853 9015042 58.44 µM -1.10674851416631 0.12907281979518 no 2942 0.134201336899325 4118 6457456
SGTC_1133 3473-0247 50 µM -1.10714501177256 0.128988434053021 no 2943 0.134115618636551 4180 711311
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.10930860798772 0.128528634502996 no 2944 0.133648536459163 4185 442882
SGTC_3035 9091303 49.47 µM -1.11071588010667 0.128230177482029 no 2945 0.13334533231036 4267 25237002
SGTC_767 0929-0023 86 µM -1.112288547597 0.127897212932783 no 2946 0.133007053174501 4210 1204563
SGTC_1575 cyproterone acetate 48 µM -1.11480929141376 0.127364776100113 no 2947 0.132466077001914 4211 9880 An androgen receptor antagonist and liver toxin.
SGTC_869 0564-0080 44.1 µM -1.11485477470484 0.127355183204006 no 2948 0.132456329790206 4205 6843321
SGTC_894 0960-0238 55.9 µM -1.11525395670361 0.127271013155034 no 2949 0.132370805040926 4204 6741907 YDL195W SEC31
SGTC_3044 9093193 49.47 µM -1.11632043998239 0.127046328242603 no 2950 0.132142497678572 4238 25236277
SGTC_184 1494-0393 24.714 µM -1.1195951476479 0.126358144062123 no 2951 0.131443162145549 4178 3090647
SGTC_3245 9134821 49.47 µM -1.12033110088159 0.126203840658945 no 2952 0.131286346740714 4228 17014901
SGTC_2477 5967686 25.23 µM -1.12169902663316 0.125917383972271 no 2953 0.130995215279542 4203 776118
SGTC_1921 5740136 50 µM -1.12175223471931 0.125906250860854 no 2954 0.130983900184806 4176 1774243
SGTC_1730 st033808 45.1 µM -1.12389399523413 0.12545868471494 no 2955 0.13052899951675 4151 1045166
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.12504650975896 0.125218302511171 no 2956 0.130284663062891 4223 688669
SGTC_2395 5646831 180.19 µM -1.12638303424209 0.124939943933791 no 2957 0.130001712422461 4242 6808628
SGTC_3113 9123498 49.47 µM -1.12660358505254 0.124894051299123 no 2958 0.129955061347029 4321 8897275
SGTC_2039 Aminomethylbenzodioxan 200 µM -1.13080602791056 0.124021848535446 no 2959 0.129068371136163 4196 15053
SGTC_1399 3562-5772 25 µM -1.13089776887872 0.124002855667075 no 2960 0.129049061244206 4181 23847490
SGTC_3308 9128332 17.569 µM -1.13191272089744 0.12379286888836 no 2961 0.128835565012399 4230 17332805 YDL196W YDL196W
SGTC_1540 guanosine 70.6 µM -1.13664987951647 0.122816075292643 no 2962 0.127842339750413 4125 6802 Guanosine is a purine nucleoside
SGTC_1147 3809-1045 12.3 µM -1.1373795479617 0.122666100698877 no 2963 0.127689826651019 4235 325925
SGTC_132 0417-1715 25.805 µM -1.13905831777165 0.122321537635274 no 2964 0.127339415605867 4216 6769098
SGTC_1203 3992-3522 103 µM -1.14146369151955 0.121829025981186 no 2965 0.126838506562316 4357 5322312
SGTC_2306 7482397 179.52 µM -1.14377981599278 0.121356106703124 no 2966 0.12635748125572 4248 891448
SGTC_3126 9127922 49.47 µM -1.14603435798098 0.120897002903021 no 2967 0.125890468049754 4281 45595682
SGTC_1991 st073000 8.92 µM -1.14791337411331 0.120515304243168 no 2968 0.125502163259365 4303 4301969 YIL048W NEO1
SGTC_3315 9136395 68.55 µM -1.14886437226126 0.120322444624271 no 2969 0.125305955304332 4234 16876844
SGTC_1023 4482-3888 16 µM -1.14965411509627 0.120162452428462 no 2970 0.125143180050633 4251 3303168
SGTC_2951 9072950 58.06 µM -1.15157224288018 0.119774487674853 no 2971 0.124748446473379 4204 16488155
SGTC_88 0180-0332 8.668 µM -1.15203984795828 0.119680042897218 no 2972 0.124652349581192 4319 3101745
SGTC_572 0960-0087 17.7 µM -1.16051136674714 0.117978092566679 no 2973 0.122920334286327 4230 6796365
SGTC_1868 st057644 42.7 µM -1.16220478812259 0.11763994330865 no 2974 0.122576145102089 4270 688665
SGTC_99 0109-0120 622.8 µM -1.16339018122714 0.117403647756894 no 2975 0.122335615726819 4208 759414
SGTC_2293 7624732 200 µM -1.16483658368626 0.117115778268986 no 2976 0.122042573650483 4146 894453
SGTC_1963 st076565 50.3 µM -1.16546441104518 0.1169909810317 no 2977 0.121915528968096 4271 4914280
SGTC_2714 st079313 56.9 µM -1.16756050999427 0.116575008743909 no 2978 0.121492043531445 4244 2939799
SGTC_368 fentichlor 4.58 µM -1.16809526676383 0.116469054030421 no 2979 0.121384169681337 4276 7329 A pesticide.
SGTC_2336 9001819 198.65 µM -1.17397155220199 0.115309246535148 no 2980 0.120203210218649 4330 2989602
SGTC_333 3486-0131 40.1 µM -1.17530985661884 0.115046255912607 no 2981 0.119935386276047 4297 6744690
SGTC_489 paxilline 115 µM -1.1769033132649 0.114733681866855 no 2982 0.119617049748955 4254 105008 A toxic potassium channel blocker.
SGTC_50 0929-0078 56.389 µM -1.17730929367264 0.114654141022231 no 2983 0.119536039413378 4114 1377751
SGTC_1400 3771-8998 51.5 µM -1.17810690877137 0.11449798428373 no 2984 0.119376994054119 4195 670767
SGTC_1049 3226-0134 66 µM -1.17836572586211 0.114447345733158 no 2985 0.119325417733883 4290 5702385
SGTC_2391 6285546 200 µM -1.17918195389027 0.11428775203551 no 2986 0.119162865180159 4263 846083
SGTC_2744 captopril 92.04 µM -1.18057476829407 0.11401578683425 no 2987 0.118885845997568 4329 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_945 3381-0768 11.3 µM -1.1814878093887 0.113837754014426 no 2988 0.118704496713482 4290 1126236 YIL048W NEO1
SGTC_441 propafenone 146 µM -1.18291983738863 0.113558923726864 no 2989 0.11842045944372 4256 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_432 NS 1619 61.3 µM -1.18349893093031 0.1134463067624 no 2990 0.118305734981716 4261 4552 A K+/calcium channel activator.
SGTC_153 4077-0274 519.67 µM -1.18583002667925 0.112993781627382 no 2991 0.117844715496678 4324 3121976
SGTC_1011 4112-3381 17.4 µM -1.18613517159093 0.11293464071133 no 2992 0.117784461380421 4337 2877139
SGTC_2525 harmine 47.85 µM -1.18662156644196 0.112840416965242 no 2993 0.117688462608557 4261 5280953 A monoamine oxidase inhibitor
SGTC_1310 1188-0297 994 nM -1.18771821550996 0.112628181555324 no 2994 0.117472222410078 4144 1588352
SGTC_357 1325-0123 420 µM -1.18952595906654 0.112278950021631 no 2995 0.117116381061118 4292 1098503
SGTC_1647 st011722 22.4 µM -1.19096524031381 0.11200145425648 no 2996 0.116833615444943 4253 2854783
SGTC_1733 st037357 54.9 µM -1.19124401755404 0.111947762286413 no 2997 0.116778902004542 4173 1272339 YGL099W LSG1
SGTC_3240 9133527 49.47 µM -1.19240963926189 0.111723465105573 no 2998 0.116550331258156 4232 17617455
SGTC_1995 st072814 61.1 µM -1.19322716620905 0.111566342701765 no 2999 0.116390209026292 4237 5769371
SGTC_3135 9127742 49.47 µM -1.19516104024179 0.111195296484973 no 3000 0.116012058514399 4377 3643468
SGTC_328 k915-0120 63.5 µM -1.19654584501434 0.110930141859989 no 3001 0.115741809658431 4272 6624543
SGTC_3087 9117406 49.47 µM -1.19973503681328 0.11032121675342 no 3002 0.115121130557675 4318 42546093
SGTC_1472 k841-0093 193 µM -1.20014656423586 0.110242817126058 no 3003 0.115041211993695 4399 X1472
SGTC_1273 0849-0096 14.1 µM -1.20106833917596 0.110067355825997 no 3004 0.11486234661475 4303 5286025
SGTC_3005 9076496 71.4286 µM -1.20545431363995 0.109235223300931 no 3005 0.114013982416437 4251 21368410
SGTC_2910 7948405 25.97 µM -1.2060407467959 0.109124305298541 no 3006 0.113900889855078 4213 2971328
SGTC_1445 4239-0156 97.7 µM -1.20800961965191 0.108752504642471 no 3007 0.113521781088182 4358 4008346
SGTC_1446 4239-0190 62 µM -1.21063023655453 0.10825904344291 no 3008 0.113018575262329 4311 1340085
SGTC_33 0986-0033 35.816 µM -1.21191547800717 0.108017622787656 no 3009 0.112772368319793 4265 2848082
SGTC_2648 atorvastatin 78.68 µM -1.21244996927938 0.107917337781954 no 3010 0.112670091465299 4291 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2348 9022543 33.42 µM -1.21648877411864 0.107161715897772 no 3011 0.111899392417318 4320 3162678 YDL140C RPO21
SGTC_3343 9148379 18.9835 µM -1.21811794297051 0.10685799632941 no 3012 0.111589578130356 4328 1955036
SGTC_2332 7982454 138.89 µM -1.22105790804002 0.106311482747826 no 3013 0.111032047598526 4222 2981748
SGTC_2697 mebhydrolin 72.4 µM -1.2216036240772 0.106210261466075 no 3014 0.110928778745108 4361 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_102 gallobenzophenone 83.616 µM -1.22221341090459 0.10609723848895 no 3015 0.110813466837762 4294 70837
SGTC_2991 9074669 71.4286 µM -1.22329390373658 0.105897184375707 no 3016 0.110609354446522 4290 17333109
SGTC_1009 4106-0057 9.87 µM -1.22706812115789 0.105200524581808 no 3017 0.10989849420661 4305 2928005
SGTC_698 k064-0052 127 µM -1.22773770357997 0.105077277605745 no 3018 0.109772723961735 4396 5088751
SGTC_1791 st048313 56.1 µM -1.22893401567454 0.104857338120967 no 3019 0.1095482733133 4319 1204976
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.22989713546812 0.104680512897918 no 3020 0.109367813527763 4345 4620898
SGTC_2026 5148700 152 µM -1.22995560592692 0.104669784896343 no 3021 0.109356864795472 4281 79838
SGTC_2888 9058547 12.99 µM -1.23333986308974 0.104050206775239 no 3022 0.108724495624992 4214 16476514
SGTC_3233 9132340 49.47 µM -1.23356449086715 0.104009177006371 no 3023 0.108682615806956 4316 17682950
SGTC_2246 7293507 91.5585 µM -1.23448132821886 0.103841832185075 no 3024 0.108511800089278 4366 887656
SGTC_905 2-aminofluorene 215 µM -1.23580100543792 0.103601302410541 no 3025 0.108266270587891 4329 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1493 4348-0038 111 µM -1.23586108552394 0.10359036159786 no 3026 0.108255102049876 4287 800424
SGTC_1014 4130-3005 69.3 µM -1.24102312370976 0.102653463035105 no 3027 0.107298603365057 4334 743608
SGTC_2677 mitomycin C 100 µM -1.24418022936212 0.102083499155123 no 3028 0.106716619232599 4386 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.24773255479539 0.101444941692999 no 3029 0.106064507568378 4255 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1464 k208-0027 110 µM -1.24793405052134 0.101408808698738 no 3030 0.106027604833578 4322 X1464
SGTC_1651 st011928 86.1 µM -1.25105477951852 0.100850384021224 no 3031 0.105457246137422 4324 720198
SGTC_2893 9048488 25.97 µM -1.25326510473447 0.100456226078176 no 3032 0.105054621679097 4369 6467338
SGTC_3220 9131269 49.47 µM -1.25541723549439 0.100073526892393 no 3033 0.104663667887319 4346 17722206
SGTC_2784 7567673 72.73 µM -1.2640438402186 0.0985501993279842 no 3034 0.10310714599908 4269 3471247
SGTC_2737 bleomycin 30.5 nM -1.26405790546683 0.0985477295577795 no 3035 0.103104621970538 4447 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1767 st044992 70.3 µM -1.26670420589848 0.0980838615421724 no 3036 0.102630537784206 4380 9600693
SGTC_2712 st079126 47.7 µM -1.26696759390897 0.098037780139827 no 3037 0.102583438719654 4324 3152970
SGTC_836 0330-0104 1.35 µM -1.26840078993293 0.0977873113995222 no 3038 0.102327429841361 4363 46494820
SGTC_1943 st076331 65.2 µM -1.26982534593163 0.0975388177844685 no 3039 0.102073425084885 4334 24208415
SGTC_2165 5727197 32.143 µM -1.27113660197869 0.0973104973467975 no 3040 0.101840027976758 4428 1361712
SGTC_839 0122-0028 230 µM -1.27219618622801 0.0971262855139858 no 3041 0.101651711171438 4360 759448
SGTC_2552 juarezic acid 87.02 µM -1.27233574600794 0.0971020417235286 no 3042 0.10162692653005 4284 1549512
SGTC_2086 5274770 176.623 µM -1.27472513051759 0.0966876557371374 no 3043 0.101203274340659 4386 689278
SGTC_3012 9080433 71.4286 µM -1.27602667414742 0.0964624789074885 no 3044 0.10097304500781 4343 17688859
SGTC_2447 5741742 33.78 µM -1.2762756024063 0.0964194563781138 no 3045 0.100929055755317 4402 1776504
SGTC_740 k014-0057 261 µM -1.2785372545344 0.0960292185361264 no 3046 0.100530028842604 4345 4012779
SGTC_2894 9048625 32.47 µM -1.27865846809731 0.0960083365218578 no 3047 0.100508675480685 4372 4092861
SGTC_391 gliotoxin 8.33 µM -1.27928747909284 0.09590002754466 no 3048 0.100397920067947 4425 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_878 0828-0289 13.7 µM -1.28097353255672 0.09561015046935 no 3049 0.100101481402534 4293 745350 YLR208W SEC13
SGTC_1497 4476-2978 41.3 µM -1.28198572692775 0.0954364375596698 no 3050 0.0999238265972743 4398 1528379
SGTC_1094 duloxetine 25.4 µM -1.28911387437621 0.0942196786194253 no 3051 0.0986792503861755 4379 60834 A selective serotonin reuptake inhibitor.
SGTC_1441 4106-0040 13 µM -1.29056148914013 0.0939739780964157 no 3052 0.0984278885718202 4371 2904180
SGTC_1285 0929-0069 65.5 µM -1.2921663583284 0.0937021401395867 no 3053 0.0981497696840028 4395 1206237
SGTC_1780 st038448 24.544 µM -1.29466768110756 0.0932796162104883 no 3054 0.0977174467543374 4384 728868 YDL195W SEC31
SGTC_403 arphamenine a 50 µM -1.30091363200734 0.0922306980561428 no 3055 0.0966440097193232 4357 5487158 An arginine aminopeptidase inhibitor.
SGTC_3203 9113543 49.47 µM -1.30194639187317 0.0920581052629068 no 3056 0.0964673559981456 4404 17018012
SGTC_2961 9083290 32.55 µM -1.30345227898862 0.0918068731061826 no 3057 0.0962101991501044 4310 17741490
SGTC_2037 5169046 200 µM -1.30411249745421 0.0916968869460194 no 3058 0.0960976142043249 4418 5718022
SGTC_840 0245-0196 390 µM -1.30550565852999 0.0914651198671666 no 3059 0.0958603608067623 4459 3827528
SGTC_2904 7225135 42.03 µM -1.30594319360395 0.0913924209479198 no 3060 0.0957859381660915 4437 4446116
SGTC_1298 1079-1278 263 µM -1.30708480347326 0.0912029377261992 no 3061 0.0955919558884992 4352 2840950
SGTC_3211 9128781 49.47 µM -1.3124662858008 0.0903136469270101 no 3062 0.094681427131608 4330 17194361
SGTC_1229 0139-0193 12.2 µM -1.31716273072317 0.0895428349880413 no 3063 0.0938920417513865 4451 3090752
SGTC_1849 st056239 19.2 µM -1.31757871918081 0.0894747967664219 no 3064 0.093822356675719 4360 5393181
SGTC_2228 7354201 200 µM -1.31981009802786 0.0891104931834228 no 3065 0.0934492146404025 4465 753451
SGTC_2776 terbinafine 19.92 µM -1.32011763973329 0.0890603694110647 no 3066 0.093397872089143 4394 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_275 trichlorophene 5.69 µM -1.3217322421997 0.0887975624570332 no 3067 0.0931286641059991 4423 62616
SGTC_348 k064-0012 10.7 µM -1.32178831694167 0.0887884456239512 no 3068 0.093119324894493 4310 5066323
SGTC_2189 6047310 154.431 µM -1.33337626782803 0.0869193545477684 no 3069 0.091204178237739 4366 711535
SGTC_3285 9112818 20.8695 µM -1.33641064495253 0.0864348125342247 no 3070 0.0907075444303574 4365 17017947 YPR165W RHO1
SGTC_1072 oxiconazole 14.9 nM -1.33663472368753 0.0863991109441081 no 3071 0.0906709493977093 4390 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2363 9053361 176 µM -1.3376025595722 0.0862450360869949 no 3072 0.0905130148173496 4443 6469797 YMR079W SEC14
SGTC_1638 st008370 60.6 µM -1.33942522135064 0.0859554350949005 no 3073 0.0902161416249071 4327 24207134
SGTC_440 fluspirilene 35.1 µM -1.34136831068022 0.0856475015443975 no 3074 0.0899004505039119 4438 3396 An atypical antipsychotic.
SGTC_635 k038-0028 24.7 µM -1.34176918623773 0.0855840751859247 no 3075 0.0898354230747841 4383 4035102
SGTC_1374 2889-5571 141 µM -1.34512228353328 0.0850549264031381 no 3076 0.0892928740844738 4414 2853281
SGTC_1928 4'-methoxychalcone 40.3 µM -1.34781163381912 0.0846322978444185 no 3077 0.0888594875624478 4415 641818
SGTC_234 nsc-17383 10.7 µM -1.35052957778435 0.0842067780757225 no 3078 0.0884230863484462 4418 408974
SGTC_1319 1306-0155 43.7 µM -1.35123693750415 0.0840962980357609 no 3079 0.0883097728805782 4445 3122360
SGTC_2760 etidronate 98.04 µM -1.35230727412549 0.0839293328605396 no 3080 0.0881385191826544 4358 3305 A chelator and antioxidant.
SGTC_1621 st003705 32.4 µM -1.3545450143622 0.0835810651825105 no 3081 0.0877812811602196 4397 24207032
SGTC_2225 6654152 15.4 µM -1.36098073098547 0.0825855041013686 no 3082 0.0867598894577449 4336 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1950 st077106 7.18 µM -1.36622381733249 0.081781054042769 no 3083 0.0859343620439072 4322 13831864
SGTC_2600 tangeritin 87.95 µM -1.36636272702293 0.0817598216431115 no 3084 0.0859125708306355 4315 68077 A bioactive flavone.
SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.36988957235415 0.0812221330181305 no 3085 0.0853606876390875 4451 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1956 st077085 54 µM -1.37006731115393 0.0811951064602688 no 3086 0.0853329454019553 4441 24208685
SGTC_1155 4088-0394 48.2 µM -1.37239283114259 0.0808421181100486 no 3087 0.0849705903074096 4407 2326248
SGTC_2278 7948257 134.34 µM -1.37371850091009 0.0806414151752479 no 3088 0.0847645454918823 4423 1247028
SGTC_2406 ethylparaben 405.7 µM -1.37383093777459 0.0806244098560354 no 3089 0.0847470870232878 4391 8434 A possible steroid mimic.
SGTC_1321 1326-2144 215 µM -1.37496350114612 0.0804532682817815 no 3090 0.0845713802633335 4390 3513030
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -1.37813198629569 0.0799759367453715 no 3091 0.0840812707427063 4441 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2083 5306046 65.942 µM -1.37862758402887 0.0799014691318395 no 3092 0.0840048036386673 4398 539837
SGTC_3023 9089636 49.47 µM -1.38053189086664 0.0796158192312856 no 3093 0.0837114687755562 4498 17249241
SGTC_564 3555-0129 330 µM -1.38116823564217 0.0795205386533572 no 3094 0.0836136194745938 4324 563260
SGTC_2249 haloperidol 116.36 µM -1.38227309141687 0.0793553124322867 no 3095 0.0834439324680955 4375 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2197 6588183 93.1375 µM -1.38452496953708 0.0790193589242689 no 3096 0.0830988839331233 4418 884136
SGTC_2619 obliquin 87.91 µM -1.38857795943736 0.0784174166606711 no 3097 0.0824805616896742 4387 6708593 A bioactive alkalod. YER133W GLC7
SGTC_90 0870-0863 4.608 µM -1.38915504947009 0.0783319918642116 no 3098 0.0823928035439894 4434 1738164
SGTC_15 0266-0086 27.098 µM -1.38937335648494 0.0782996949757948 no 3099 0.0823596239067086 4501 1712902 YIL048W NEO1
SGTC_2262 9014885 67.46 µM -1.39101824704936 0.07805667034623 no 3100 0.0821099467967013 4455 6457424
SGTC_1766 st045414 44.774 µM -1.39122019486434 0.0780268730170944 no 3101 0.0820793325815882 4430 253960
SGTC_1192 1488-0095 21.4 µM -1.39149902927852 0.077985745282272 no 3102 0.082037076901157 4458 915875
SGTC_2968 9090663 33.37 µM -1.3959461747898 0.0773320179848114 no 3103 0.0813653521843965 4378 25236811
SGTC_2035 5154463 94.595 µM -1.39731909588517 0.0771310427794069 no 3104 0.081158817963408 4449 2769623
SGTC_781 4335-2806 94.4 µM -1.3981637731798 0.0770075919561416 no 3105 0.0810319463584089 4486 845254
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -1.39872958736827 0.0769249814122599 no 3106 0.0809470441031955 4467 6708784 An antioxidant flavonoid
SGTC_2481 5478948 45.16 µM -1.40362204868961 0.0762134749299774 no 3107 0.0802157129401793 4437 77792
SGTC_2054 5233173 129 µM -1.40407995428201 0.0761471392910223 no 3108 0.0801475210469059 4438 6889
SGTC_72 0744-0168 198.391 µM -1.40433084685865 0.076110811752302 no 3109 0.0801101763868168 4322 677577
SGTC_2782 7736369 71.43 µM -1.40487812889235 0.0760316148137861 no 3110 0.0800287606268451 4434 2950836 YOL077C BRX1
SGTC_2193 5925765 200 µM -1.4131681523972 0.0748396294419075 no 3111 0.0788031441211288 4443 877370
SGTC_2172 5754775 163.918 µM -1.41525020440398 0.0745425123503732 no 3112 0.0784975746740727 4431 2263357
SGTC_1614 st002383 48.6 µM -1.42227861426405 0.0735461780915879 no 3113 0.0774726923360904 4480 1947235
SGTC_3198 9112019 49.47 µM -1.42544569974715 0.0731005598212427 no 3114 0.0770142029175067 4496 45595555
SGTC_3085 9117376 49.47 µM -1.4270672443613 0.0728732049151272 no 3115 0.0767802564641053 4517 16480349
SGTC_1429 4049-0205 9.46 µM -1.42816792873918 0.072719187919759 no 3116 0.0766217646478512 4503 22774478
SGTC_2434 5670830 169.91 µM -1.4285619538578 0.0726641132464783 no 3117 0.0765650879626249 4479 1549830
SGTC_2965 9082772 38.63 µM -1.42946512140172 0.072537993963399 no 3118 0.0764352964084075 4452 16459634
SGTC_832 4083-0019 164 µM -1.43080479079949 0.0723512299961313 no 3119 0.0762430848382887 4533 1990758
SGTC_837 0091-0265 12.5 µM -1.43658756020059 0.0715492768125785 no 3120 0.0754176101854324 4440 759367
SGTC_107 0358-0022 2.6945 µM -1.43684897491735 0.0715131856648405 no 3121 0.07538045550023 4482 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_523 1934-0222 13.7 µM -1.44077547700625 0.0709727686513803 no 3122 0.0748240618218727 4406 1361595
SGTC_2720 fluspirilene 36.88 µM -1.44198709986908 0.0708066440055134 no 3123 0.0746530064232995 4442 3396 An atypical antipsychotic.
SGTC_1130 3454-2858 15.9 µM -1.44542963639564 0.0703362707824264 no 3124 0.0741686219696507 4431 715628 YIL048W NEO1
SGTC_2652 actinonin 100 µM -1.44680808209704 0.0701486010297154 no 3125 0.0739753412736537 4509 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_608 k048-0125 159 µM -1.44815131539501 0.0699660960659145 no 3126 0.0737873683920799 4508 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1318 1280-3875 124 µM -1.44853562935689 0.0699139466456305 no 3127 0.0737336544877451 4466 373245
SGTC_2832 7992762 51.95 µM -1.45133181313837 0.0695354190179362 no 3128 0.0733437433897693 4402 2985177
SGTC_3140 9094243 49.47 µM -1.45211251165653 0.0694300158812677 no 3129 0.0732351617932965 4416 19291112
SGTC_1343 1487-0095 224 µM -1.45247962100002 0.0693804945198837 no 3130 0.0731841457946129 4458 4560101 YGL055W OLE1
SGTC_2164 5685496 200 µM -1.45255430454432 0.0693704233844788 no 3131 0.0731737705931818 4383 759046
SGTC_1419 3993-2473 62.6 µM -1.45345332660564 0.0692492778894096 no 3132 0.0730489647800796 4540 704026
SGTC_512 prima-1 270 µM -1.45884251789164 0.0685264849166218 no 3133 0.0723042285889518 4478 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.45905484228888 0.068498127790237 no 3134 0.0722750069023869 4506 16486 A toxic proline analog.
SGTC_2778 tioconazole 65.09 nM -1.45974965255778 0.0684053952196545 no 3135 0.0721794451324973 4367 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_979 1426-2828 121 µM -1.46211830213532 0.0680899922055218 no 3136 0.0718543971005191 4546 747872
SGTC_2008 4012253 172 µM -1.46230538285729 0.0680651289549565 no 3137 0.0718287720624185 4462 603940
SGTC_1387 3342-1166 1.8 µM -1.46816295172155 0.0672901911578622 no 3138 0.0710299825671136 4458 3418228
SGTC_414 piperonyl butoxide 100 µM -1.47118909460332 0.066892523144098 no 3139 0.0706199927946693 4480 5794 A potent inhibitor of cytochrome P450.
SGTC_350 k064-0020 19.8 µM -1.47411672410741 0.0665095334774301 no 3140 0.0702250831780474 4495 2790705
SGTC_3019 9081971 49.47 µM -1.47617422460946 0.0662413905097203 no 3141 0.0699485635611763 4484 16451803
SGTC_622 1348-1566 26.3 µM -1.4775039061391 0.0660685461624909 no 3142 0.0697703059990909 4471 7340407
SGTC_2626 ethyl orsellinate 100 µM -1.48919840461284 0.0645634012309605 no 3143 0.0682175654018454 4420 75653 A natural product.
SGTC_2493 resveratrol 26.09 µM -1.48975135433623 0.0644928986238211 no 3144 0.0681448130775005 4436 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2979 9012552 45.46 µM -1.49491664569579 0.0638371955790592 no 3145 0.0674680987352476 4497 17100905
SGTC_879 0831-1030 162 µM -1.49786341899021 0.063465449855036 no 3146 0.0670843698010118 4498 1549252
SGTC_1105 epirubicin 18.1 µM -1.50206832091759 0.0629379069801581 no 3147 0.0665397326301733 4534 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1923 st058458 19.1 µM -1.50381425978931 0.0627198694655548 no 3148 0.0663145992356951 4491 3534982
SGTC_1167 k781-0610 148 µM -1.50465610940489 0.0626149476042603 no 3149 0.0662062563404832 4521 4525169
SGTC_305 1682-2595 20.8 µM -1.5060079530497 0.0624467501922666 no 3150 0.0660325660273898 4511 226033
SGTC_377 3970-0964 33.1 µM -1.506791092831 0.0623494726241419 no 3151 0.0659321067004919 4485 16481235
SGTC_296 1222-0039 74.9 µM -1.51090627475679 0.0618402467772151 no 3152 0.0654061659762474 4519 5984176
SGTC_1836 st055642 81 µM -1.51177944661501 0.0617326163213016 no 3153 0.0652949898927589 4492 8571
SGTC_22 0964-0034 14.468 µM -1.51212831479844 0.0616896544238456 no 3154 0.0652506114708808 4511 138402
SGTC_2462 5162487 171.77 µM -1.5146650389065 0.0613779673397099 no 3155 0.0649286261785887 4467 2259986
SGTC_1908 st060353 56.5 µM -1.51999388047237 0.060727220594012 no 3156 0.0642562568307292 4515 4227716
SGTC_2740 felodipine 17.08 µM -1.52032404929189 0.0606870792875474 no 3157 0.0642147763102318 4558 3333 L-type calcium channel blocker
SGTC_2649 anisomycin 9.56 µM -1.53095483919183 0.0594056663150087 no 3158 0.0628902771980835 4556 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_621 3584-0052 32.1 µM -1.53915681056385 0.058431591166406 no 3159 0.0618830093015736 4544 2273927
SGTC_2214 7179297 48.276 µM -1.54130482011757 0.0581785750311505 no 3160 0.0616213081652256 4580 769744
SGTC_1418 3966-3099 2.4 µM -1.54229871790863 0.058061794505613 no 3161 0.0615005101866782 4528 740335
SGTC_995 3931-2021 34.6 µM -1.54315970094907 0.0579607801069917 no 3162 0.0613960161912923 4530 730143
SGTC_49 0717-0965 32.132 µM -1.54542799219443 0.0576953152519029 no 3163 0.061121386917446 4567 5889349 YGL099W LSG1
SGTC_2628 lathosterol 100 µM -1.55210998283562 0.0569188563240579 no 3164 0.0603179548764822 4541 6710616
SGTC_2450 5739737 12.93 µM -1.55464250307347 0.0566267324154953 no 3165 0.0600156176024495 4537 2262825
SGTC_665 3914-0008 307 µM -1.55786664147626 0.0562565415934141 no 3166 0.059632432193921 4495 1069549
SGTC_1816 st051957 91.6 µM -1.55941136585297 0.0560798559664445 no 3167 0.0594495239526082 4536 674121
SGTC_2171 5739187 198.077 µM -1.56086264568527 0.0559142575263567 no 3168 0.0592780812794651 4496 2262761
SGTC_1436 4092-1007 8.32 µM -1.56237965295722 0.0557415718552132 no 3169 0.0590992887517232 4535 2881121
SGTC_2139 5578692 56.4705 µM -1.5632195363481 0.05564614646871 no 3170 0.0590004832504117 4506 650991 YMR113W FOL3
SGTC_1351 1496-0003 46.5 µM -1.56364369576251 0.0555980035925248 no 3171 0.0589506335926752 4547 3891978
SGTC_2867 9039098 71.43 µM -1.57247669229329 0.0546028941236156 no 3172 0.0579200202140801 4506 6463460
SGTC_2313 7726885 200 µM -1.5768730750343 0.0541128824193374 no 3173 0.0574123665044212 4542 726423
SGTC_2588 indole-3-carbinol 100 µM -1.57825421448485 0.05395966396678 no 3174 0.0572536099087017 4507 3712 Induces cell cycle arrest.
SGTC_686 1319-0111 510 µM -1.58382837694192 0.0533447746325099 no 3175 0.0566163899040917 4544 4562600
SGTC_1347 1493-0251 600 nM -1.58701385086149 0.0529958845190623 no 3176 0.0562547538224576 4578 3986378
SGTC_2591 skatole 100 µM -1.59344837580628 0.0522966619743379 no 3177 0.0555298203409724 4538 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_3004 9076122 71.4286 µM -1.59597565393893 0.0520240412776244 no 3178 0.0552471145248495 4543 44782551
SGTC_3063 1327-0034 4 µM -1.60203464846222 0.0513750474482554 no 3179 0.0545739739024355 4436 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1982 st072467 71.9 µM -1.60240417844608 0.0513356754753492 no 3180 0.0545331307232366 4529 3163533
SGTC_1261 0712-0010 12.7 µM -1.60759514647393 0.0507851310956558 no 3181 0.0539619379524882 4528 2840123
SGTC_2540 epiandrosterone 100 µM -1.61040617184738 0.0504889672002501 no 3182 0.053654607049599 4573 441302 A steroid.
SGTC_1744 st037937 38.9 µM -1.61066824859692 0.0504614255990331 no 3183 0.0536260248590263 4566 1016152
SGTC_1899 st063254 59.6 µM -1.61236785450164 0.0502831047197052 no 3184 0.0534409578211762 4511 3093813
SGTC_515 4092-1064 102 µM -1.61360658225514 0.0501534553887349 no 3185 0.0533063941050753 4518 717353
SGTC_812 4251-0442 148 µM -1.62824559997499 0.0486413874021591 no 3186 0.0517364096593028 4580 5723007
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.63029837708541 0.0484322998946647 no 3187 0.0515192252088964 4500 6708739 YPR165W RHO1
SGTC_1411 3909-8223 150 µM -1.6326742975902 0.0481911964010277 no 3188 0.0512687579408418 4595 X1411
SGTC_1235 benzylparaben 21.5 µM -1.63620709273981 0.0478344722424536 no 3189 0.0508981262558595 4598 7180
SGTC_67 0335-0847 266 µM -1.63794238211353 0.0476600272182972 no 3190 0.0507168568610051 4566 4552207 YOR254C SEC63
SGTC_1457 k015-0032 57.3 µM -1.63849847347543 0.0476042324363623 no 3191 0.0506588761141783 4564 4302660
SGTC_835 0312-0010 67.2 µM -1.63875946746171 0.0475780639530381 no 3192 0.0506316818415462 4588 1626196
SGTC_649 1123-0311 367 µM -1.6396631685761 0.0474875436439614 no 3193 0.0505376105108502 4466 693629 YIL048W NEO1
SGTC_3228 9131799 49.47 µM -1.64276521901045 0.0471778722562638 no 3194 0.0502157595019646 4587 17015818
SGTC_179 1273-0063 6.77 µM -1.65773634139996 0.0457060255307565 no 3195 0.0486853476043249 4554 3108139
SGTC_209 4077-0173 175.592 µM -1.66344480135904 0.0451546267565947 no 3196 0.0481117157125281 4548 15993494
SGTC_3130 9127414 49.47 µM -1.66528824060197 0.0449777106615587 no 3197 0.0479276317412714 4607 1494646
SGTC_1629 st005085 44.9 µM -1.66942387314889 0.0445828409636733 no 3198 0.0475167028462252 4540 24207091
SGTC_1046 2001-0062 216 µM -1.67081727855948 0.0444504294361655 no 3199 0.0473788872946695 4526 739778
SGTC_843 0310-0051 143 µM -1.67435624254063 0.0441155553401956 no 3200 0.047030303560466 4592 2065037
SGTC_2097 5376186 200 µM -1.67496090995363 0.0440585427261822 no 3201 0.0469709507545673 4551 742755
SGTC_2539 epi(13)torulosol 80 µM -1.67793463771328 0.043779021182402 no 3202 0.0466799298366726 4543 6708597
SGTC_2473 5854593 8.94 µM -1.69243784493544 0.0424362024472242 no 3203 0.0452812608364723 4559 2872951
SGTC_3244 9134489 49.47 µM -1.69992313119897 0.04175630316198 no 3204 0.0445726926707335 4588 16584271
SGTC_1721 st082152 9.2685 µM -1.70152141990794 0.0416122774016009 no 3205 0.0444225595581347 4532 5296051
SGTC_32 0928-0142 34.1 µM -1.7030525727809 0.0414746791103135 no 3206 0.0442791151750727 4602 2244242
SGTC_1958 st076513 41.9 µM -1.70719621767178 0.0411041553331869 no 3207 0.0438927939094296 4523 732122 YGL099W LSG1
SGTC_558 k064-0027 21.3 µM -1.71033104792251 0.0408256267556552 no 3208 0.0436023367825137 4600 5088526
SGTC_86 0417-1630 471.922 µM -1.71520816645549 0.0403953426346655 no 3209 0.0431535340784004 4602 3634867
SGTC_410 α-linolenic acid 100 µM -1.72563316025674 0.0394879425514804 no 3210 0.0422067148708782 4626 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2504 purpurogallin 52.29 µM -1.72725947213853 0.0393478936392124 no 3211 0.0420605371241389 4549 5281571 An antioxidant.
SGTC_2006 4011487 200 µM -1.73171894706855 0.0389659410292612 no 3212 0.0416618077354281 4545 45595294
SGTC_60 0986-0278 202 µM -1.73988363883168 0.0382744639135208 no 3213 0.0409397260664185 4559 3110598
SGTC_1209 2323-2347 50.3 µM -1.74864651793215 0.0375434912564488 no 3214 0.0401760700372756 4619 5412760
SGTC_2654 protoveratrine a 100 µM -1.75376485610689 0.0371218352369221 no 3215 0.039735403634141 4625 5702278 A heart drug and vasodilator.
SGTC_1850 st056238 17 µM -1.75465659248863 0.0370487701013778 no 3216 0.0396590325262454 4615 5393177
SGTC_2365 9042475 200 µM -1.75790694874546 0.0367834440045929 no 3217 0.0393816716550762 4622 6464479
SGTC_2044 5102272 200 µM -1.76052188545618 0.0365711168221373 no 3218 0.0391596800525325 4617 592666
SGTC_3163 9099914 49.47 µM -1.76145597808652 0.0364955140240305 no 3219 0.0390806288209341 4691 16268368
SGTC_2558 carylophyllene oxide 100 µM -1.76497073601431 0.0362121846598136 no 3220 0.0387843420474607 4682 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_563 tetrahydrosecaminediol 614 µM -1.76508864802469 0.0362027109231508 no 3221 0.0387744341195795 4657 334274 A psychoactive constituent of the cannabis plant.
SGTC_1211 1056-0033 32.3 µM -1.76572419385797 0.0361516824143247 no 3222 0.0387210658804318 4640 6741922
SGTC_587 k089-0003 57 µM -1.77697893836268 0.0352577448142716 no 3223 0.0377858525948036 4564 9659696
SGTC_2903 5923464 63.88 µM -1.77982473328317 0.0350346052533346 no 3224 0.0375523242714413 4631 2876576
SGTC_256 clotrimazole 625 nM -1.78302160997005 0.0347853208674895 no 3225 0.0372913928261945 4572 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1681 tripelennamine 100 µM -1.7834475761397 0.0347522153252228 no 3226 0.0372567372512586 4545 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1377 2944-0135 198 µM -1.78445231619019 0.0346742306946288 no 3227 0.037175098259813 4619 1894137
SGTC_2066 5222451 176 µM -1.78957336937202 0.0342789813562829 no 3228 0.0367612614115242 4566 2281147
SGTC_3206 9114350 49.47 µM -1.80236549115085 0.0333078271300777 no 3229 0.0357439604145051 4504 17087243
SGTC_1835 st008666 49.2 µM -1.80443391492262 0.033152945033708 no 3230 0.0355816551749541 4599 690455
SGTC_159 3970-0959 50 µM -1.80511279340673 0.0331022406037469 no 3231 0.0355285167538063 4636 6615653
SGTC_530 4358-1714 28 µM -1.81300842328701 0.0325172069138659 no 3232 0.0349152610809685 4622 1564641
SGTC_2739 tacrine 100.86 µM -1.81363053978243 0.032471475417947 no 3233 0.0348673126969441 4667 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_3279 9140807 49.47 µM -1.81396388188995 0.0324469934334102 no 3234 0.0348416432710717 4678 45595718
SGTC_595 3909-8003 73.7 µM -1.81408625374935 0.0324380097742613 no 3235 0.0348322237670867 4675 699517
SGTC_304 1310-0298 97 µM -1.81917745170911 0.0320660655655478 no 3236 0.0344421808627429 4381 1550234
SGTC_104 0074-0074 590.992 µM -1.83437716632011 0.0309765279955489 no 3237 0.0332990133288774 4550 3943124
SGTC_2705 st078069 42.8 µM -1.83576345128815 0.0308787000794502 no 3238 0.0331963245447917 4636 1530061
SGTC_1886 st057356 49.9 µM -1.84277874334984 0.0303875557687382 no 3239 0.0326806608008579 4631 24207747
SGTC_2285 7945142 200 µM -1.84894735334964 0.0299610528978693 no 3240 0.0322327075417538 4641 2970608
SGTC_1067 clotrimazole 1.36 µM -1.85735222212176 0.0293879345183544 no 3241 0.0316305295937917 4681 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_605 1315-0399 119 µM -1.86044294439936 0.0291794839636176 no 3242 0.0314114418248422 4690 24020461
SGTC_480 am 92016 50 µM -1.87889658631156 0.0279603067693988 no 3243 0.0301293075317866 4661 2129 K+ channel blocker.
SGTC_3189 9110682 49.47 µM -1.88166087254523 0.0277813851386409 no 3244 0.0299410377467089 4640 17122418
SGTC_3248 9135562 49.47 µM -1.88284431522535 0.0277050776028269 no 3245 0.029860734729307 4628 17650701
SGTC_1637 st007924 17.4 µM -1.88465382106441 0.0275887397298659 no 3246 0.029738295403407 4583 683336
SGTC_135 0933-0004 26.348 µM -1.89370588981397 0.0270128557889278 no 3247 0.0291320295594265 4577 21230617 YGL099W LSG1
SGTC_378 3970-0959 8.33 µM -1.90959623032091 0.026026197504275 no 3248 0.0280926104337009 4664 6615653
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.91418905750602 0.0257467010340127 no 3249 0.0277980017094141 4657 688662
SGTC_1712 st032288 53.4 µM -1.91421539617551 0.025745105467854 no 3250 0.0277963196572636 4454 2883011
SGTC_429 1112-0049 25.5 µM -1.91466910483497 0.0257176333106508 no 3251 0.0277673580172216 4619 2836170
SGTC_2337 9009472 200 µM -1.91929386296772 0.0254390004309945 no 3252 0.0274735771327113 4608 5742383
SGTC_150 3970-0969 77.2 µM -1.92459399351717 0.0251227913081269 no 3253 0.0271400857188616 4656 6615640
SGTC_1645 Cervolide 78 µM -1.92605983838476 0.0250359218899497 no 3254 0.0270484513049227 4694 23173 A fragrance.
SGTC_226 1,3-diallylurea 8.28947 mM -1.92666486702236 0.0250001399569228 no 3255 0.0270107044807991 4640 74537 YKL182W FAS1
SGTC_1964 st076914 61 µM -1.92742894742432 0.0249550128332976 no 3256 0.0269630974877481 4685 24208661
SGTC_623 k072-0108 16.9 µM -1.95107213410732 0.0235920177818433 no 3257 0.0255242327602056 4660 5382803
SGTC_2862 9027634 71.43 µM -1.95416174353775 0.0234186205829834 no 3258 0.0253410460156438 4639 5012562
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.95625291100276 0.0233018681780082 no 3259 0.0252176841640311 4678 688751
SGTC_1526 st051518 75 µM -1.9737781741775 0.0223425347088674 no 3260 0.0242034858204381 4644 673993
SGTC_3338 9144300 39.5675 µM -1.98168005919554 0.0219210073480026 no 3261 0.0237575302043228 4672 4901274
SGTC_2587 piperic acid 92.2 µM -2.00938176778427 0.0204959110175985 no 3262 0.0222483311346219 4635 5370536
SGTC_3281 9140613 49.47 µM -2.01823731612003 0.0200572332106375 no 3263 0.0217832757584835 4672 16013766
SGTC_566 0958-0068 16.5 µM -2.02362316429748 0.019794348738878 no 3264 0.0215044698806909 4618 6815365
SGTC_2515 chrysin 20.77 µM -2.02954291508315 0.0195087838271378 no 3265 0.0212015112617281 4695 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_165 k038-0023 64.381 µM -2.03552623278176 0.0192237158812082 no 3266 0.020898975880739 4654 46368543
SGTC_1336 1486-0901 104 µM -2.03587204452972 0.019207348892929 no 3267 0.0208816028241042 4696 5006114
SGTC_1833 st055984 71 µM -2.05848894033053 0.0181623280190328 no 3268 0.0197716109234383 4711 676288
SGTC_2808 7946468 45.46 µM -2.06887774021882 0.0176987926779026 no 3269 0.0192787804597493 4675 2970879
SGTC_211 3455-0679 143.504 µM -2.086756521023 0.0169246910572256 no 3270 0.0184550746057488 4661 748649
SGTC_1661 st013063 9.66 µM -2.0899309352939 0.01679031834647 no 3271 0.0183120021010992 4743 721395
SGTC_620 0109-0052 432 µM -2.09259180228058 0.016678388091909 no 3272 0.0181928044928756 4724 493037
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -2.09530233301601 0.0165650257398821 no 3273 0.0180720626085304 4735 16725076
SGTC_3204 9114183 49.47 µM -2.09971821691272 0.0163817528901453 no 3274 0.0178768180638324 4648 17027248
SGTC_1879 gemcitabine 100 µM -2.10263667441679 0.0162615831484175 no 3275 0.0177487707476479 4684 60750 A nucleoside analog which inhibits DNA replication.
SGTC_351 caspofungin 25 nM -2.11865041551021 0.0156155587489746 no 3276 0.0170600108404247 4697 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -2.12140440628191 0.0155067063841851 no 3277 0.0169438923907428 4739 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1893 st059353 36.1 µM -2.12438854374093 0.0153894932341059 no 3278 0.0168188335851096 4708 3112488
SGTC_2329 6138490 200 µM -2.12906108957524 0.0152074898141877 no 3279 0.0166246032406374 4680 720019
SGTC_178 4092-0806 87.505 µM -2.15376400592009 0.0142756988229733 no 3280 0.015629341888025 4607 2169044
SGTC_1118 chelidonine 707.474 nM -2.15661783924932 0.0141712892715465 no 3281 0.0155177266988291 4697 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2315 7733312 200 µM -2.1647656298867 0.0138768095654331 no 3282 0.015202819083681 4664 726316
SGTC_1509 1326-1131 80 µM -2.16709993662746 0.0137934209677061 no 3283 0.0151136173815974 4709 768313
SGTC_2120 5538279 151.968 µM -2.17278630532515 0.0135920931579604 no 3284 0.014898202247556 4728 2058197
SGTC_1571 st070080 73.4 µM -2.17968215733656 0.0133513501121454 no 3285 0.0146405150320652 4707 4315245
SGTC_1152 3909-8331 15.9 µM -2.18546512836304 0.0131523070065448 no 3286 0.0144273800452292 4724 16001939
SGTC_1410 3909-8106 77.9 µM -2.19651205358639 0.0127792045216713 no 3287 0.0140276566899947 4753 1039210
SGTC_1910 st062352 60.4 µM -2.21745819544808 0.0120968506306123 no 3288 0.0132958983634543 4672 2245730
SGTC_1960 st011366 51.8 µM -2.22580505760838 0.0118338709072144 no 3289 0.0130136209543485 4746 3972846
SGTC_217 ketoconazole 989 nM -2.23523906036433 0.0115426240588421 no 3290 0.0127008292034926 4579 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_967 1306-0166 352 µM -2.23535166504811 0.0115391856566571 no 3291 0.0126971353430518 4722 4437607
SGTC_1797 st048695 56.8 µM -2.23842643849011 0.0114456400987539 no 3292 0.0125966297649849 4713 592262 YIL048W NEO1
SGTC_741 4582-0002 126 µM -2.23864310738336 0.0114390731766751 no 3293 0.0125895735212536 4741 2912688
SGTC_1467 k284-1082 293 µM -2.24019116876666 0.011392248832154 no 3294 0.0125392573754758 4719 3334705
SGTC_2923 7992654 58.14 µM -2.24516773546969 0.0112428485862447 no 3295 0.0123786832659222 4700 2985126
SGTC_1148 3909-7663 27.7 µM -2.24622950638044 0.0112111947953623 no 3296 0.0123446555974486 4741 4084526
SGTC_23 0213-0011 39.996 µM -2.26651575659158 0.0106211257048819 no 3297 0.0117099117694968 4731 627608
SGTC_455 paf C-16 10 µM -2.27733160175368 0.0103177220023671 no 3298 0.0113832155874625 4712 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_251 melphalan 456.522 µM -2.28278478878744 0.0101676362717312 no 3299 0.0112215242043502 4756 460612 A DNA alkylator.
SGTC_341 1486-1430 230 µM -2.29714792639019 0.00978140566754696 no 3300 0.0108051662732511 4720 2054753 YPL210C SRP72
SGTC_2111 5486399 200 µM -2.31540702530843 0.00930895592855959 no 3301 0.0102953337078059 4716 689674
SGTC_3223 9129970 49.47 µM -2.32739813802693 0.00900966107714224 no 3302 0.00997204238807105 4730 17248386
SGTC_24 0417-1663 219 µM -2.33442182079748 0.00883829469335759 no 3303 0.00978682265183478 4752 4329390
SGTC_1430 4049-0248 69.1 µM -2.35434030275846 0.00836775964701445 no 3304 0.00927780747663422 4756 22774488
SGTC_2713 st079149 53.4 µM -2.36253099861236 0.00818074386674781 no 3305 0.00907531170663927 4755 3103253
SGTC_1390 3413-2614 145 µM -2.36467515509526 0.00813239755599191 no 3306 0.00902294588609047 4743 3421432
SGTC_513 4245-1575 41.7 µM -2.38970872934135 0.00758625037569089 no 3307 0.00843086970333617 4619 719745
SGTC_604 1000-0114 314 µM -2.3948103116844 0.00747899918827978 no 3308 0.00831448282316966 4769 1572745
SGTC_1959 st077091 55.8 µM -2.40858811138468 0.00719599400090827 no 3309 0.00800718005200478 4744 821356 YKL052C ASK1
SGTC_265 mycophenolic acid 32.932 µM -2.42147587837777 0.00693986390956814 no 3310 0.00772881344186263 4762 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3193 9111931 49.47 µM -2.42999877357731 0.00677493431726338 no 3311 0.00754943696202918 4741 17087244
SGTC_2805 7950783 58.44 µM -2.46683714185718 0.00610122948389858 no 3312 0.00681561693456031 4734 1178958 YDL195W SEC31
SGTC_2691 st077356 60.2 µM -2.48439187482207 0.00580159928724595 no 3313 0.00648864556933536 4731 2839272
SGTC_1210 3013-0140 750 nM -2.48539308616397 0.00578491072419355 no 3314 0.00647042261091262 4767 905973
SGTC_607 4491-0986 66.8 µM -2.50230883724481 0.00550932135097705 no 3315 0.00616931194244321 4758 698981 YDR232W HEM1
SGTC_2106 5357045 167.29 µM -2.51071066411303 0.00537682561345447 no 3316 0.00602442034128365 4770 668842
SGTC_1907 st060210 83.7 µM -2.52852032601339 0.00510529786569872 no 3317 0.00572722268679411 4760 688793
SGTC_2835 9006588 71.43 µM -2.53206131742678 0.00505278982147746 no 3318 0.00566970799094245 4699 2345538
SGTC_2105 5350118 200 µM -2.5369960058307 0.00498041728967715 no 3319 0.00559041148935428 4763 2133313
SGTC_1798 st045719 60.953 µM -2.53781466791041 0.00496850044035568 no 3320 0.00557735193377004 4756 3980186
SGTC_2570 licareol 100 µM -2.55545442302497 0.00471782319792585 no 3321 0.00530246241271958 4730 443158
SGTC_1069 diphenylcyclopropenone 8.49 µM -2.59038370946601 0.0042544898605748 no 3322 0.00479345032110912 4775 65057 A dermal irritant. YDR527W RBA50
SGTC_1426 4048-4480 71.7 µM -2.64645156226812 0.00359538598829288 no 3323 0.00406705767184946 4782 14224343
SGTC_138 0850-0259 40.9225 µM -2.65611765520281 0.00349150934213215 no 3324 0.00395230153040663 4725 6813004
SGTC_105 0111-0055 734.78 µM -2.66865819549699 0.00336076228565573 no 3325 0.00380774530609065 4780 5179370
SGTC_481 bay k-8644 50 µM -2.67698185114353 0.00327642758262636 no 3326 0.00371443294539123 4775 2303 A calcium channel antagonist.
SGTC_1570 verbenone 133 µM -2.68837232278009 0.00316410482719417 no 3327 0.00359006440559629 4768 29025 A natural terpanoid with antifungal properties.
SGTC_1781 st038725 66.3 µM -2.69977056620224 0.00305518654856856 no 3328 0.00346936545837477 4769 4270275 YIL048W NEO1
SGTC_207 4185-0010 4.486 µM -2.7029246946006 0.00302564913127637 no 3329 0.00343661581595967 4773 3761753
SGTC_134 0269-0018 6.916 µM -2.75610810351185 0.00256486112738188 no 3330 0.00292468305175571 4752 4378915
SGTC_2969 9091408 28.7 µM -2.76046018328389 0.00253011802334186 no 3331 0.00288599967013413 4742 4286311
SGTC_1071 trifluoperazine 6.31 µM -2.76209138269385 0.00251720599405221 no 3332 0.00287162006224784 4788 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3138 9097216 49.47 µM -2.77680989719903 0.0024033655744699 no 3333 0.00274476379173373 4740 25237486
SGTC_423 5-fluorouracil 457 µM -2.80284241630125 0.0022133670744618 no 3334 0.00253272064705097 4767 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2651 TUB2.036 5 µM -2.82599178100468 0.00205595944405795 no 3335 0.00235672367187053 4689 15992207 YFL037W TUB2
SGTC_1237 0330-0133 46.1 µM -2.84301597371011 0.00194676002272552 no 3336 0.00223444153064904 4771 X1237 YHR072W ERG7
SGTC_1557 sumaresinolic acid 42.3 µM -2.89906515963728 0.00162343487750875 no 3337 0.00187138551696931 4783 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_212 3807-4682 38.772 µM -2.91924725758476 0.00151955340354748 no 3338 0.0017543889666552 4794 3125501 YBL034C STU1
SGTC_2142 5622915 118.518 µM -2.9276175401811 0.00147827722121123 no 3339 0.00170784962895572 4796 5322196
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -3.06478490517373 0.000932477262900767 yes 3340 0.00108913297012903 4755 4330530
SGTC_1061 3448-9325 110 µM -3.09407181038762 0.00084314445616721 yes 3341 0.000987148467336924 4786 723482
SGTC_691 1548-0686 185 µM -3.11332517066447 0.000788779807843842 yes 3342 0.000924960375926176 4793 46495133
SGTC_1747 st037496 66.6 µM -3.13737195691673 0.000725415660806446 yes 3343 0.000852348570617102 4763 723305
SGTC_2582 agaric acid 100 µM -3.30134087113736 0.000403819315901381 yes 3344 0.000481119502733866 4641 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_2495 cafestol 54.53 µM -3.33816247191575 0.000352790874690792 yes 3345 0.000421672107169108 4783 16667697 An anti-infammatory.
SGTC_1897 st060201 15 µM -3.34119216328378 0.000348870923338535 yes 3346 0.000417097324965589 4803 611878
SGTC_1057 3448-5381 134 µM -3.34468791717134 0.0003443982716959 yes 3347 0.000411876022279242 4792 5497911
SGTC_2122 5258151 111.688 µM -3.3974200884817 0.000283080498972498 yes 3348 0.000340122262097298 4801 2173356
SGTC_2773 thioridazine 9.09 µM -3.4158772869202 0.000264137973824215 yes 3349 0.000317884449994078 4795 5452 An antipsychotic.
SGTC_214 4373-3496 70 µM -3.42843610786897 0.000251931587694045 yes 3350 0.000303534704757492 4801 3779166
SGTC_2112 5488546 200 µM -3.4814677201146 0.000205961553203102 yes 3351 0.000249336941756215 4795 600757
SGTC_703 3875-0075 71.8 µM -3.64861894187987 0.000107221856019438 yes 3352 0.000131826915840814 4807 2850814
SGTC_2807 7945238 51.95 µM -3.72878246665296 7.7651525579587e-05 yes 3353 9.6203577159067e-05 4793 17148797
SGTC_2113 5491891 107.031 µM -4.19631691859749 1.04408871397663e-05 yes 3354 1.35645284202105e-05 4806 789979
SGTC_2505 galangin 7.89 µM -4.30613489544294 6.31827221829135e-06 yes 3355 8.30658852805686e-06 4809 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_416 estradiol valerate 100 µM -4.51811835064107 2.3172926670254e-06 yes 3356 3.11958046257797e-06 4809 13791 A steroid.