SGTCid condition conc unit DER1|YBR201W.score DER1|YBR201W.strain.pval DER1|YBR201W.strain.significant DER1|YBR201W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2539 epi(13)torulosol 80 µM 6.75169390319273 5.12904122418034e-12 yes 1 7.30644601654171e-12 2 6708597
SGTC_536 3852-0578 10.6 µM 4.70181562500257 1.11147326838307e-06 yes 2 1.28929145182564e-06 14 2869208
SGTC_2663 amphotericin b 100 µM 4.57174727857646 2.10612535179751e-06 yes 3 2.41837033814614e-06 7 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2102 5377816 72.7585 µM 4.54266864766175 2.42412364028985e-06 yes 4 2.77732630640862e-06 12 1379702
SGTC_2582 agaric acid 100 µM 4.24816633566815 9.61107647861128e-06 yes 5 1.07763675216187e-05 288 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_823 0417-1665 178 µM 4.18882231723573 1.25560659536988e-05 yes 6 1.40202917971678e-05 33 3429856
SGTC_2954 9074818 52.69 µM 4.13659889716212 1.58405801112861e-05 yes 7 1.76245736192592e-05 33 16648742
SGTC_2585 alliin 100 µM 4.06707107810255 2.14948576462743e-05 yes 8 2.38038627858959e-05 21 87310 A garlic compound which reacts with lipids.
SGTC_2309 7664088 163.95 µM 4.00200680306394 2.84796464080345e-05 yes 9 3.14037461645313e-05 27 704922
SGTC_3233 9132340 49.47 µM 4.00003208412308 2.87220481723044e-05 yes 10 3.16669482832009e-05 15 17682950
SGTC_2541 muurolladie-3-one 83.07 µM 3.99478956222377 2.93750966106059e-05 yes 11 3.23758700624053e-05 25 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1717 st033143 58.0435 µM 3.95768491619797 3.4415381726602e-05 yes 12 3.78398477586816e-05 39 674616
SGTC_2091 4-phenylthiadiazole 200 µM 3.90379388369529 4.32119501487624e-05 yes 13 4.73482184017281e-05 16 270010
SGTC_2088 5278280 127.392 µM 3.8238012560041 6.02662043044128e-05 yes 14 6.57049271461353e-05 26 791502
SGTC_2802 7925815 54.55 µM 3.80817446760662 6.42660498020444e-05 yes 15 6.99982444352107e-05 49 1262923
SGTC_1903 st060211 78.3 µM 3.80317491989599 6.55976901839229e-05 yes 16 7.14267063784609e-05 33 688960
SGTC_860 0443-0016 25.1 µM 3.78589340619333 7.04036797054556e-05 yes 17 7.65786604099657e-05 36 5337942
SGTC_1041 0206-0046 107 µM 3.68357471620994 0.000106372010704526 yes 18 0.000114992915256263 41 50494
SGTC_2270 7924575 90.91 µM 3.66475596710902 0.000114633945682297 yes 19 0.00012378726433698 20 1262135
SGTC_1219 1469-0211 33.1 µM 3.43716205357637 0.000275705102250264 yes 20 0.00029392189030285 25 6822282
SGTC_990 3985-0011 41.3 µM 3.36826045365704 0.000356088645480766 yes 21 0.000378220496409539 36 5399565 YGL099W LSG1
SGTC_657 3534-0529 86.7 µM 3.35689699778548 0.000371272785086258 yes 22 0.000394112354961491 28 1049549
SGTC_2547 epiafzelechin trimethyl ether 100 µM 3.3314139993103 0.000407536004608165 yes 23 0.000432029969337217 5 6708630 An antioxidant.
SGTC_592 k241-0073 46.5 µM 3.28058199990049 0.000489882120259126 yes 24 0.000517965734144256 39 4230158
SGTC_3234 9132280 49.47 µM 3.26318468869279 0.000521434074853603 yes 25 0.000550838498736787 43 17612295
SGTC_993 3909-8757 62.7 µM 3.2441546094932 0.000558093961472215 yes 26 0.000588998929737755 52 4288324 YLR208W SEC13
SGTC_880 0833-0487 87.2 µM 3.17392680147559 0.000714991948622068 yes 27 0.000751958064040155 33 76075
SGTC_104 0074-0074 590.992 µM 3.16346279612683 0.000741579404914242 yes 28 0.000779521384864163 21 3943124
SGTC_472 calcifediol 10 µM 3.14461455149013 0.000791780302070361 yes 29 0.000831528940020148 21 5283731 A vitamin D metabolite.
SGTC_2090 5301565 104.445 µM 3.13770072011779 0.000810965971838442 yes 30 0.00085139321142624 84 2056344
SGTC_3037 9091026 49.47 µM 3.11342112083658 0.000881781103000172 yes 31 0.000924659679984723 195 25236398 YIL048W NEO1
SGTC_2010 4012422 159 µM 3.0827621257256 0.000979317696691878 yes 32 0.00102544510008358 63 952393
SGTC_1531 st059297 52.4 µM 3.07449638283194 0.00100725853973772 no 33 0.00105429139183615 56 7566702
SGTC_1217 1183-1422 255 µM 3.03496920224623 0.00115126378546737 no 34 0.00120280125125997 47 2849664
SGTC_2667 digitoxin 100 µM 3.00979304186043 0.00125257119825134 no 35 0.00130712878107969 21 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_3187 9109394 49.47 µM 3.00182918457167 0.00128627621839397 no 36 0.0013418135696526 78 17098090
SGTC_3004 9076122 71.4286 µM 2.98049023997608 0.00138071679865485 no 37 0.00143893704318959 58 44782551
SGTC_3094 9117742 49.47 µM 2.96935043745931 0.00143249623275421 no 38 0.0014921502349759 77 17149698
SGTC_789 1309-1135 70.6 µM 2.94314101232925 0.00156138580754104 no 39 0.00162450195670043 78 3092424
SGTC_2699 st077704 54.6 µM 2.92383632498838 0.001662987599239 no 40 0.00172873246636299 108 645852
SGTC_178 4092-0806 87.505 µM 2.91105793437884 0.00173351515721368 no 41 0.00180103610708618 173 2169044
SGTC_1914 st062367 72.6 µM 2.90924047093052 0.001743764444556 no 42 0.0018115403094493 69 978205
SGTC_3013 9080133 71.4286 µM 2.88336078527057 0.0018958157056274 no 43 0.00196728258771115 74 17050193
SGTC_309 k408-0051 1.48 µM 2.87653866548559 0.00193785608436981 no 44 0.00201031466937512 141 3640463
SGTC_151 3013-0144 2.285 µM 2.85351392958026 0.00208607016312227 no 45 0.00216193161297491 96 906558 YHR107C CDC12
SGTC_1747 st037496 66.6 µM 2.85232107333054 0.00209402187497447 no 46 0.00217006191990035 79 723305
SGTC_1885 st057546 99.9 µM 2.84662168368888 0.00213239550243518 no 47 0.00220929192545869 66 702008
SGTC_1220 1838-0075 193 µM 2.83373235183269 0.00222154085181848 no 48 0.00230039238942213 64 5529645
SGTC_2866 9034245 58.44 µM 2.81765192399966 0.00233748570541695 no 49 0.00241881111166397 48 6462273
SGTC_600 1495-0418 41.6 µM 2.807132617102 0.00241626913799628 no 50 0.0024992329517474 57 5377768
SGTC_3264 9137442 49.47 µM 2.80418426689174 0.0024387775382899 no 51 0.00252220332695579 46 17015726
SGTC_1667 st014849 34.6 µM 2.79573921718977 0.00250430266441022 no 52 0.00258905822887688 43 5348460
SGTC_1131 3454-3128 32.3 µM 2.7700838676046 0.00271324110745846 no 53 0.00280209301902477 113 710982
SGTC_2815 7968870 71.43 µM 2.75973164949388 0.00280191545847795 no 54 0.00289244290605998 95 2977326 YHR190W ERG9
SGTC_563 tetrahydrosecaminediol 614 µM 2.73572512995205 0.00301769159202759 no 55 0.00311214967983191 88 334274 A psychoactive constituent of the cannabis plant.
SGTC_2264 7948757 110.76 µM 2.72820280036133 0.0030883205925717 no 56 0.00318402222236452 90 2971411
SGTC_106 0092-0003 11.579 µM 2.70669956087349 0.00329850246432966 no 57 0.00339778628243899 56 1072148
SGTC_45 0kpi-0036 14.9 µM 2.70428388011092 0.00332290053374933 no 58 0.00342258908601499 88 2795021
SGTC_380 3970-0968 6 µM 2.70337317292534 0.0033321405944578 no 59 0.0034319818420648 79 2891601
SGTC_811 0416-0114 265 µM 2.7006220392699 0.00336019412993225 no 60 0.00346049701320115 99 6612453
SGTC_2054 5233173 129 µM 2.68733119952016 0.00349873459755338 no 61 0.0036012748252258 162 6889
SGTC_1962 st076595 64.5 µM 2.65856718321146 0.00381627005778692 no 62 0.00392368515126381 118 279619
SGTC_7 0192-1582 4.227 µM 2.65560334158036 0.00385041433753769 no 63 0.00395833364289936 170 252616
SGTC_2584 androsterone 48.74 µM 2.64549981075695 0.00396887671786671 no 64 0.0040785166324544 266 2754130 A steroid.
SGTC_256 clotrimazole 625 nM 2.63612591021606 0.00408169238058512 no 65 0.00419293042372916 119 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_36 0335-0881 14.2 µM 2.63026406897576 0.00415369046952973 no 66 0.00426592835292685 231 23828853
SGTC_2206 7254556 146.969 µM 2.62607653046549 0.00420581751541711 no 67 0.00431876973279089 42 4398905
SGTC_826 1683-5028 118 µM 2.61324959083174 0.0043691491712018 no 68 0.00448428894574698 94 722377
SGTC_2188 6126565 140.678 µM 2.58009988155104 0.00481781256588126 no 69 0.00493858712538211 81 874518
SGTC_2646 retinol 96.75 µM 2.56742255464804 0.00499996841507114 no 70 0.00512288367048157 80 445354 A vitamin A analog and teratogen.
SGTC_1066 ketoconazole 628 nM 2.56498530708269 0.00503568318771072 no 71 0.00515900870768938 107 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_3007 9078383 71.4286 µM 2.55755990987457 0.00514589745708497 no 72 0.00527046995927607 104 6496995
SGTC_775 4577-0580 57.3 µM 2.53438721323176 0.00550377921731879 no 73 0.0056322091271018 75 2006902
SGTC_1155 4088-0394 48.2 µM 2.52637288138769 0.00563260476620437 no 74 0.00576235436382005 114 2326248
SGTC_974 1326-0144 138 µM 2.51568196180421 0.00580862033602003 no 75 0.00594011668155744 148 5411856
SGTC_2642 cholecalciferol 100 µM 2.51032841898467 0.00589858156930316 no 76 0.00603094617955019 81 9821465 A vitamin D precursor, similar to steriods.
SGTC_3355 9151058 44.0485 µM 2.50761589071481 0.00594463299891242 no 77 0.00607743579077211 86 17015728
SGTC_1045 1348-1485 165 µM 2.50118137834736 0.00605515104794469 no 78 0.00618898832515135 158 6810614
SGTC_1288 0973-0013 65.5 µM 2.49275189498604 0.00620268786261493 no 79 0.00633786920713327 105 4315430
SGTC_134 0269-0018 6.916 µM 2.49250937013858 0.00620697936438547 no 80 0.00634219918276082 253 4378915
SGTC_3259 9138485 49.47 µM 2.49195333220769 0.00621682843958134 no 81 0.00635213642451846 110 17646153
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 2.48610723188782 0.00632122089939424 no 82 0.00645745218693555 117 5377381
SGTC_344 k064-0035 6.43 µM 2.48548621890893 0.00633240084873538 no 83 0.00646872981393701 114 5088750
SGTC_2643 anethole 100 µM 2.47710439133157 0.00648501832575286 no 84 0.00662265776217066 117 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1860 st056228 74.6 µM 2.46403009702065 0.00672957638739241 no 85 0.00686922873586845 109 688679
SGTC_2991 9074669 71.4286 µM 2.45993138033663 0.00680790412857493 no 86 0.00694817912192784 176 17333109
SGTC_1055 3448-0672 86 µM 2.44695303558958 0.00706126252630523 no 87 0.00720348052454681 139 748378
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 2.4377371781835 0.00724618800056112 no 88 0.00738975758485657 121 688664
SGTC_1359 1582-0056 520 nM 2.43588416624971 0.00728388202616199 no 89 0.00742772038412774 123 3661189
SGTC_1283 0922-0125 16.4 µM 2.42695237025102 0.00746800814158244 no 90 0.00761312733977599 113 3360884
SGTC_1279 0874-0590 65.2 µM 2.41589151442413 0.0077016987076044 no 91 0.00784836864043396 134 3523074
SGTC_1754 st042065 16.137 µM 2.4139838035384 0.00774264864187586 no 92 0.00788958188044661 332 1126236 YIL048W NEO1
SGTC_1826 st055655 41.6 µM 2.37569101800078 0.00860613116462142 no 93 0.00875806175786333 160 676168
SGTC_2993 9054257 71.4286 µM 2.36791267217082 0.00879150682089664 no 94 0.0089443788665297 195 6470217 YGL055W OLE1
SGTC_1678 st019265 80.2 µM 2.35251355791792 0.00916885127459508 no 95 0.00932350498733186 163 5367020
SGTC_1818 st052136 56.3 µM 2.32928851406466 0.00976477650479655 no 96 0.0099218932236262 190 674169
SGTC_2000 st075254 36.4 µM 2.32819443544415 0.00979366512849225 no 97 0.00995089076670157 97 17234175
SGTC_428 3448-4153 16.5 µM 2.32424014848557 0.00989869959022493 no 98 0.0100563133073559 158 3834874
SGTC_2147 5545932 89.7195 µM 2.31699466051316 0.0100937096708147 no 99 0.0102520113153411 112 797404
SGTC_1655 st012546 55.1 µM 2.31502949518879 0.0101471760210667 no 100 0.0103056589753319 132 720985 YLR208W SEC13
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 2.2982213467866 0.0106146592432047 no 101 0.0107745971703762 157 5393153
SGTC_1221 2958-7315 257 µM 2.29795725060038 0.0106221517890432 no 102 0.0107821111681086 134 4562705
SGTC_1321 1326-2144 215 µM 2.29665125419457 0.0106592713403546 no 103 0.0108193361433896 119 3513030
SGTC_3034 9090421 49.47 µM 2.29323730382063 0.0107568381156055 no 104 0.0109171732857992 102 17173761
SGTC_1463 k081-0032 34.1 µM 2.28683213804534 0.0109419897065204 no 105 0.0111028114279706 89 977755
SGTC_2833 9001315 45.46 µM 2.27878698461526 0.0111784719314023 no 106 0.0113398654859457 201 2989378
SGTC_334 1502-1024 68.5 µM 2.27554798021868 0.0112749278260661 no 107 0.0114365389260087 151 3296216
SGTC_544 k015-0020 52.4 µM 2.23729408923685 0.0124699731246981 no 108 0.0126335626423341 153 3008304
SGTC_1285 0929-0069 65.5 µM 2.23067965342376 0.0126873645849715 no 109 0.0128511781664429 167 1206237
SGTC_3175 9106517 49.47 µM 2.22689672206837 0.0128131634387315 no 110 0.0129770884878279 130 41468073
SGTC_438 sphingosine 6.67 µM 2.22612467445957 0.012838969522467 no 111 0.0130029158076081 134 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_3032 9089427 49.47 µM 2.22576846542526 0.0128508911383722 no 112 0.0130148470474267 141 17173707
SGTC_1386 3228-0095 33.8 µM 2.22124285904402 0.0130031898317718 no 113 0.0131672583754824 137 870181
SGTC_2830 7992007 71.43 µM 2.21959319098462 0.0130590923316815 no 114 0.0132231974520498 162 1952075
SGTC_2797 7859098 81.82 µM 2.20920341505895 0.0134159684455366 no 115 0.0135802477346212 168 972681
SGTC_3109 9122853 49.47 µM 2.20426684889138 0.0135884641428283 no 116 0.0137527914601074 125 1234709
SGTC_1352 1496-0991 99 µM 2.19675902013464 0.0138544743713118 no 117 0.014018830613914 165 3000039
SGTC_889 0919-1524 82.7 µM 2.1751838640931 0.0146440399928544 no 118 0.0148081704329367 159 3905452
SGTC_3062 9077494 49.47 µM 2.17012517589819 0.0148346738281577 no 119 0.0149986822226228 172 16459633
SGTC_1325 1431-0015 227 µM 2.15825718838467 0.0152903063538803 no 120 0.0154539206409854 158 1103340
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 2.14968868347846 0.0156266910951627 no 121 0.0157899240937786 162 688798
SGTC_1413 3910-0535 34.4 µM 2.14945903034191 0.015635793573138 no 122 0.0157990152096633 159 2876951
SGTC_1904 st060225 78 µM 2.13794179855424 0.0160981600872311 no 123 0.0162607336247597 148 66595
SGTC_572 0960-0087 17.7 µM 2.13473152546535 0.0162291080938602 no 124 0.0163914731670663 241 6796365
SGTC_2515 chrysin 20.77 µM 2.1099450308954 0.0172712162421258 no 125 0.01743154545235 161 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_576 1073-0113 22.7 µM 2.09507887596432 0.0179232616679228 no 126 0.0180819907060688 316 5439563
SGTC_794 k038-0031 316 µM 2.08864468975514 0.0182119155792393 no 127 0.0183698595805508 301 6624242
SGTC_312 4092-0653 6.84 µM 2.08359684071433 0.0184411393759524 no 128 0.0185984273158434 285 1148278
SGTC_414 piperonyl butoxide 100 µM 2.08280996717773 0.0184770919026324 no 129 0.0186342743518821 149 5794 A potent inhibitor of cytochrome P450.
SGTC_3133 9127736 49.47 µM 2.07560270900617 0.0188091800874321 no 130 0.0189653553449766 184 27243420
SGTC_2981 9013952 38.96 µM 2.07513208581044 0.018831040477312 no 131 0.0189871473758121 227 2996344
SGTC_1560 lithocholic acid 53.1 µM 2.06954891010535 0.0190920319349181 no 132 0.019247303308518 115 9903 A bile acid which acts as a detergent.
SGTC_2339 9000433 200 µM 2.06368138825369 0.0193696236665143 no 133 0.0195239675713022 193 2988954
SGTC_1886 st057356 49.9 µM 2.06104301128995 0.0194955583091687 no 134 0.0196494684436468 190 24207747
SGTC_1800 st050079 29.0735 µM 2.06077057509844 0.0195086017219786 no 135 0.019662466469634 409 3645560
SGTC_2489 cantharidin 73.42 µM 2.05774994212748 0.0196537177702562 no 136 0.0198070717713659 255 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_994 3910-0338 138 µM 2.05622864817673 0.0197271495407774 no 137 0.0198802410639904 237 3479481
SGTC_1326 1431-2094 10.8 µM 2.04965071346358 0.0200473482144149 no 138 0.0201992639034846 239 616278
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 2.04520957035646 0.0202660168961198 no 139 0.0204171006854691 244 23847180
SGTC_1481 3346-2004 36 µM 2.0450645425192 0.0202731915967019 no 140 0.0204242476975949 182 2770522
SGTC_2517 totarol 10 µM 2.04089225762952 0.0204805235072734 no 141 0.0206307687791699 189 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2433 5607874 27.82 µM 2.02524912182575 0.021273939863296 no 142 0.0214208949896294 231 2252428
SGTC_107 0358-0022 2.6945 µM 2.02168646796111 0.0214582269724016 no 143 0.0216043763636789 134 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2700 st077718 96.8 µM 2.01790103116853 0.0216555149761606 no 144 0.0218007848236616 151 904970
SGTC_2258 7960471 200 µM 2.01557855981317 0.0217773136283273 no 145 0.0219220317999716 151 2974708
SGTC_2440 5628896 157.78 µM 2.00651205520957 0.0222583463383207 no 146 0.0224008219341077 184 5522048
SGTC_683 panaxydol 45 µM 1.99788028176274 0.0227246138411256 no 147 0.0228648204342516 229 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_3057 9095946 49.47 µM 1.99042174796875 0.0231341096866033 no 148 0.0232722480809508 175 24540043
SGTC_3255 9139072 49.47 µM 1.98944025641576 0.0231884562932306 no 149 0.0233263149878526 205 17646060
SGTC_642 0335-0876 158 µM 1.98771658572209 0.0232841585585816 no 150 0.0234215217703699 250 6812350
SGTC_2315 7733312 200 µM 1.98771519804306 0.023284235739524 no 151 0.0234215985502098 212 726316
SGTC_960 1222-0186 7.7 µM 1.9816989637441 0.0236208813336251 no 152 0.0237564716359915 241 3126296
SGTC_3278 9139605 49.47 µM 1.97673185087128 0.0239018984015035 no 153 0.0240359742628376 212 7958859
SGTC_3246 9135460 32.98 µM 1.9742354865018 0.024044189231305 no 154 0.024177486339098 145 41446951
SGTC_2229 7354935 190 µM 1.96809918988372 0.0243969808706374 no 155 0.0245283130283933 144 318112
SGTC_1233 0325-0408 14.2 µM 1.96559958098672 0.0245419303936291 no 156 0.024672441276993 230 12874
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.95974021104476 0.0248845435025822 no 157 0.0250130813258905 222 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1199 1638-0010 4.46 µM 1.95900194444347 0.0249279951117893 no 158 0.0250562795345791 265 3111136
SGTC_787 4152-0075 138 µM 1.95147652705123 0.0253745534928502 no 159 0.0255001929126581 229 9566539
SGTC_127 0180-0333 59.125 µM 1.95136301804418 0.0253813400860115 no 160 0.0255069387396815 319 771601
SGTC_2119 5528445 120.635 µM 1.94270283441756 0.0259036256941387 no 161 0.0260260367893545 222 791935
SGTC_3110 9122132 49.47 µM 1.93677165457449 0.0262664922476672 no 162 0.026386631146175 206 918317
SGTC_2128 5255449 168.493 µM 1.93583503970716 0.0263241805626163 no 163 0.0264439539439522 276 736008
SGTC_409 arachidonic acid 100 µM 1.93527166379175 0.0263589311946169 no 164 0.0264784838303088 223 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2798 7813637 45.45 µM 1.93085338623323 0.0266327948075563 no 165 0.0267505930521213 255 956368
SGTC_927 2425-1185 123 µM 1.91110312373893 0.0278862219488473 no 166 0.0279956649065759 247 730375
SGTC_3311 9131146 2.8755 µM 1.90779355540717 0.0281009929609849 no 167 0.0282089520267725 336 4900406 YPR165W RHO1
SGTC_2511 berberine 10.47 µM 1.90579902521652 0.0282310897855073 no 168 0.0283381427342889 213 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2576 guaiol 23.12 µM 1.90478108562836 0.0282976797228785 no 169 0.028404266771795 256 227829
SGTC_1011 4112-3381 17.4 µM 1.90376402003009 0.0283643429924069 no 170 0.0284704622064709 264 2877139
SGTC_3258 9138477 49.47 µM 1.90366302589703 0.0283709697505539 no 171 0.0284770423812413 235 4970355
SGTC_3274 9138298 49.47 µM 1.90074947775716 0.0285626984187934 no 172 0.0286674172249316 259 17015756
SGTC_347 4534-1311 26.2 µM 1.89712398193274 0.0288027812098283 no 173 0.0289057883669123 228 2862016
SGTC_1265 0819-1001 68.8 µM 1.89412176206328 0.0290028579592043 no 174 0.0291044248934514 247 3106768
SGTC_3172 9105863 49.47 µM 1.88762038242162 0.0294400893869538 no 175 0.029538465885981 128 2348785
SGTC_1695 st026914 34.495 µM 1.88633002269544 0.0295275164417162 no 176 0.0296252479750199 249 3289191
SGTC_2537 larixol 68.93 µM 1.88544102139353 0.0295878751524581 no 177 0.0296851600547557 277 6708759
SGTC_1146 3579-1023 7 µM 1.88397972406347 0.0296873123702148 no 178 0.0297838590732167 291 X1146
SGTC_2476 5806916 10.51 µM 1.87999684501684 0.0299597449520738 no 179 0.0300542539536407 223 2870194
SGTC_535 2293-4129 48.2 µM 1.87891168790593 0.03003432906004 no 180 0.0301282763335997 337 396118 YIL048W NEO1
SGTC_209 4077-0173 175.592 µM 1.86670716321931 0.0308838122792139 no 181 0.0309712464379558 166 15993494
SGTC_965 1291-5240 308 µM 1.86608173837637 0.0309278746297245 no 182 0.031014965252657 287 2834598
SGTC_2629 bisabolol 100 µM 1.86579873029972 0.030947830169681 no 183 0.0310347650248581 288 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1523 st012844 44.7 µM 1.86460816824319 0.0310318961339036 no 184 0.0311181735438747 274 4274103
SGTC_2351 9026858 72.31 µM 1.85683031146334 0.0315857539527531 no 185 0.0316676498915269 240 1409300
SGTC_144 4161-2749 112.381 µM 1.85459989070783 0.0317460802732783 no 186 0.0318266918777064 209 797501 YMR168C CEP3
SGTC_2161 5662504 8.5105 µM 1.853397853692 0.0318327631261256 no 187 0.0319126773722814 255 2859334
SGTC_361 000s-0510 1.45 µM 1.85264802825899 0.0318869344660629 no 188 0.0319664118553036 298 660
SGTC_2661 dactinomycin 12.96 µM 1.85134148981733 0.0319815076063657 no 189 0.0320602203912838 273 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1479 0549-0158 134 µM 1.8508114995764 0.0320199366694626 no 190 0.0320983380627883 285 5440202
SGTC_1999 st074831 12.5 µM 1.83426542697662 0.033238984732729 no 191 0.033307301779272 290 17112523
SGTC_407 eburnamonine 100 µM 1.83395072975943 0.0332625357449547 no 192 0.0333306540964578 234 3195
SGTC_890 0929-0006 47.2 µM 1.83126295736459 0.0334642411759004 no 193 0.0335306518788975 235 1378169
SGTC_1061 3448-9325 110 µM 1.82859252393485 0.0336656415976776 no 194 0.0337303367477401 223 723482
SGTC_2741 miltefosine 3.04 µM 1.82818789113849 0.0336962452925938 no 195 0.0337606788447164 213 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_92 0063-0024 660.874 µM 1.82721501864741 0.0337699205042436 no 196 0.0338337233035876 299 3594437
SGTC_476 mead acid 10 µM 1.82375874241418 0.0340327353689476 no 197 0.0340942768799756 173 5312531 An omega 9 fatty acid.
SGTC_1721 st082152 9.2685 µM 1.81750853476017 0.0345122706590239 no 198 0.034569641332498 254 5296051
SGTC_1752 st044819 83.042 µM 1.81535076110943 0.0346791052380141 no 199 0.0347350114059457 283 441209 YML126C ERG13
SGTC_1435 4092-0789 56.7 µM 1.81374397515634 0.0348037683537112 no 200 0.034858575721978 252 2248285
SGTC_1682 st012968 530 nM 1.8097812656449 0.0351127899477297 no 201 0.0351648571424966 239 24207270
SGTC_1796 st049173 110.4 µM 1.80942180781813 0.0351409323578921 no 202 0.0351927488515369 207 94134
SGTC_1947 st076332 61.6 µM 1.80035868345414 0.0358566332975752 no 203 0.0359020101375966 228 24208416
SGTC_2282 7944268 200 µM 1.79854141730157 0.0360015677674869 no 204 0.0360456257065523 323 2970414
SGTC_877 0771-0151 33.1 µM 1.79832497294099 0.0360188620317602 no 205 0.0360627622634504 295 6166523
SGTC_2964 9083345 53.42 µM 1.79780523826556 0.0360604174837391 no 206 0.0361039384820702 280 17741579
SGTC_980 1473-0395 201 µM 1.79581729880111 0.0362197258879075 no 207 0.0362617893009438 219 768876
SGTC_2006 4011487 200 µM 1.7954009645235 0.0362531627235723 no 208 0.0362949194559668 376 45595294
SGTC_1953 st076800 12.1 µM 1.79233900985457 0.0364998529497797 no 209 0.0365393390361689 336 297591
SGTC_954 1189-0853 2.85 µM 1.79112007369396 0.0365984395450325 no 210 0.0366370142652245 307 2828194
SGTC_2265 7929201 200 µM 1.78969083653276 0.0367143124696427 no 211 0.0367518131690036 291 1265108
SGTC_3170 9103054 49.47 µM 1.7853182066077 0.0370706803195601 no 212 0.0371048586637299 253 16432970
SGTC_341 1486-1430 230 µM 1.78462998284035 0.0371270269847749 no 213 0.0371606773827147 299 2054753 YPL210C SRP72
SGTC_427 1354-0053 47.3 µM 1.77879828163876 0.0376072979711928 no 214 0.0376364195117441 310 6813657
SGTC_3014 9081533 49.47 µM 1.77738487501609 0.0377244598543205 no 215 0.0377524687919376 276 21367265
SGTC_2543 pimpinellin 60.67 µM 1.77713548052791 0.0377451638679909 no 216 0.0377729758789701 287 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_420 mitomycin C 81.9 mM 1.77406809172582 0.0380005690124675 no 217 0.0380259439767128 311 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2628 lathosterol 100 µM 1.77251234056952 0.0381306460220873 no 218 0.0381547743179346 304 6710616
SGTC_512 prima-1 270 µM 1.76428501200041 0.038824587346391 no 219 0.0388420030440538 291 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 1.76201726645002 0.0390176603440267 no 220 0.0390331901223381 300 5355888
SGTC_1605 st000082 49.1 µM 1.76162648031623 0.0390510102134986 no 221 0.0390662134351648 279 1114022
SGTC_1867 st057372 64 µM 1.75700355198835 0.0394472969082075 no 222 0.0394586018839733 287 688837
SGTC_367 0335-0881 7.1 µM 1.75653479515361 0.039487661717672 no 223 0.0394985677875195 349 23828853
SGTC_745 0469-0705 296 µM 1.75647560522771 0.039492760970412 no 224 0.0395036166227267 346 3486736
SGTC_743 1275-0778 158 µM 1.74570205224792 0.0404298696230951 no 225 0.0404313691541759 334 2849257 YMR203W TOM40
SGTC_2257 7960413 200 µM 1.74363262982708 0.0406119236464791 no 226 0.0406115848763134 341 2974689 YIL048W NEO1
SGTC_3191 9110352 49.47 µM 1.74297461897896 0.0406699502927737 no 227 0.0406690242004274 256 17122424
SGTC_1462 k081-0014 26.5 µM 1.74220426993425 0.0407379689554539 no 228 0.0407363535503982 202 3270634
SGTC_2782 7736369 71.43 µM 1.74217484787799 0.0407405686314534 no 229 0.0407389268625479 349 2950836 YOL077C BRX1
SGTC_520 3584-0023 682 µM 1.74086607828038 0.0408563452294823 no 230 0.0408535279836058 305 1340790
SGTC_1208 2323-2347 50.3 µM 1.73698365738497 0.0412013637120862 no 231 0.0411950277756486 272 5412760
SGTC_195 4234-0266 16.654 µM 1.71790243054254 0.0429315346972627 no 232 0.0429072067168787 372 2303354
SGTC_985 1493-0307 8.71 µM 1.71524207277675 0.0431773570999306 no 233 0.0431504270575959 255 3278274
SGTC_1957 st077035 62.4 µM 1.71484701824931 0.043213957685745 no 234 0.043186639268596 286 705593
SGTC_2312 7706453 155.7 µM 1.71420128169667 0.0432738371371421 no 235 0.0432458827986957 337 976098
SGTC_3047 9092122 49.47 µM 1.7116834502559 0.0435079570641589 no 236 0.043477510066122 316 17173831
SGTC_266 formosanin C 406 nM 1.70734025112292 0.0439142103840869 no 237 0.0438794143968031 360 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2623 humulene 100 µM 1.70153253804176 0.0444622261058778 no 238 0.044421516619969 266 6187145 An anti-inflammatory.
SGTC_1963 st076565 50.3 µM 1.69841054087614 0.0447590870565742 no 239 0.0447151520048054 305 4914280
SGTC_246 cycloheximide 667 µM 1.69508426915849 0.0450771258124917 no 240 0.0450297179718335 261 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_529 4076-0302 30.3 µM 1.69299300864242 0.0452780094066512 no 241 0.0452283989936713 339 5816522
SGTC_145 3737-0113 38.366 µM 1.69112580471297 0.045457978428968 no 242 0.0454063888542394 443 6849351
SGTC_2647 atorvastatin 60.16 µM 1.68650226855374 0.0459060908748369 no 243 0.0458495492559155 310 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2251 lansoprazole 556 µM 1.68629596850454 0.0459261678717717 no 244 0.0458694035862296 250 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1303 1160-0052 261 µM 1.68497354507359 0.0460550329431555 no 245 0.0459968378430932 326 3562476
SGTC_3204 9114183 49.47 µM 1.68203575974919 0.0463423482097968 no 246 0.0462809529478486 335 17027248
SGTC_2275 7947463 200 µM 1.67860520036533 0.046679676233383 no 247 0.0466145061954711 306 1225414
SGTC_2686 alizarin 95.37 µM 1.67620605573701 0.0469167534606887 no 248 0.0468489192217932 317 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_909 3448-9333 149 µM 1.67418141874906 0.0471175732780459 no 249 0.0470474750765902 313 3344074
SGTC_1058 3448-5425 97.3 µM 1.66566224009335 0.0479701357775931 no 250 0.0478903534174666 331 7279705
SGTC_2409 alverine citrate 63.97 µM 1.66538474411203 0.0479981126702209 no 251 0.0479180105505519 357 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2403 6032726 181.2 µM 1.66403877411542 0.0481339974851668 no 252 0.0480523405156439 360 2881040
SGTC_2435 5706476 10.6 µM 1.6617643295774 0.0483643175315237 no 253 0.0482800184824341 365 5725375
SGTC_225 nsc-122657 1.016 µM 1.65790336115955 0.0487573132689091 no 254 0.0486684868234711 208 275685
SGTC_2290 7904846 200 µM 1.65748052332827 0.0488005072167298 no 255 0.048711181699772 353 2962154
SGTC_8 0354-0001 70 µM 1.6573020402851 0.0488187488847446 no 256 0.0487292125129768 453 4993152
SGTC_2306 7482397 179.52 µM 1.65290246316901 0.049270128093259 no 257 0.0491753578840761 327 891448
SGTC_3283 9109332 35.8195 µM 1.65042503479391 0.0495257653517041 no 258 0.0494280171218243 265 17027281
SGTC_3190 9110366 49.47 µM 1.64795018769616 0.0497821920997779 no 259 0.0496814466810563 275 17123768
SGTC_2281 7943571 200 µM 1.64762696463051 0.0498157603224124 no 260 0.049714621813384 348 1244024
SGTC_2717 st081029 62.2815 µM 1.64100302949095 0.0505076716545629 no 261 0.0503983931654301 300 5292846
SGTC_213 1246-0773 967 nM 1.63952127124998 0.0506634936375478 no 262 0.0505523721797962 373 6251622
SGTC_2432 5630864 12.22 µM 1.63937635191999 0.0506787539141281 no 263 0.0505674517748357 345 5714970
SGTC_1581 himbacine 57.9 µM 1.63766884443957 0.0508588334531228 no 264 0.050745396592916 389 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2162 5663267 200 µM 1.63719622671316 0.0509087672409208 no 265 0.0507947376088064 323 6456493
SGTC_1780 st038448 24.544 µM 1.63542390831622 0.051096366835397 no 266 0.0509801069298623 348 728868 YDL195W SEC31
SGTC_898 1000-0849 28.3 µM 1.63490290700407 0.0511516192443831 no 267 0.0510347014962519 317 6751807
SGTC_1395 3486-0190 4.35 µM 1.63191989183585 0.0514688852013639 no 268 0.0513481814939231 351 6748079
SGTC_1968 st069590 43.6 µM 1.62648906297527 0.0520505108344748 no 269 0.0519228290639226 329 6384066
SGTC_580 1123-0028 41 µM 1.61879647371057 0.0528832866612122 no 270 0.0527455305557899 427 1677248 YPR107C YTH1
SGTC_792 4534-1957 155 µM 1.61686472243239 0.0530940636266716 no 271 0.0529537424044861 332 1717904
SGTC_1807 st050092 58.9 µM 1.6166278359648 0.0531199565358011 no 272 0.0529793197799962 338 5008496
SGTC_1032 k061-1018 98.7 µM 1.61521365363442 0.0532747422949023 no 273 0.0531322173865255 425 4005393
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.60970941842161 0.0538806007730815 no 274 0.0537306539324952 370 390807
SGTC_2853 9015042 58.44 µM 1.60810670905981 0.0540580348854319 no 275 0.0539059050469784 331 6457456
SGTC_2327 6189656 200 µM 1.60621317117433 0.0542682619349535 no 276 0.0541135401905599 334 5349088
SGTC_2666 tannic acid 100 µM 1.60599862203862 0.0542921226571974 no 277 0.0541371063598117 403 16134267 A thiamine antagonist.
SGTC_1801 st050089 28.441 µM 1.5965161832403 0.0553550111863179 no 278 0.0551867977764419 501 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1203 3992-3522 103 µM 1.59627837402563 0.0553818769845995 no 279 0.0552133280921465 403 5322312
SGTC_2709 st078560 56 µM 1.59497902619985 0.0555288488493234 no 280 0.0553584630199522 349 17250903
SGTC_1879 gemcitabine 100 µM 1.59116179775633 0.0559624047221595 no 281 0.0557865839196641 364 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2768 sulfasalazine 50.2 µM 1.58269444135919 0.0569336453786735 no 282 0.0567455629413976 358 5384001 An antioxidant and salicylic acid derivative.
SGTC_473 2-arachidonoylglycerol 10 µM 1.58165151121812 0.0570541863222334 no 283 0.0568645738723208 370 5282280 An endocannabinoid.
SGTC_289 k017-0060 526 µM 1.57977923801812 0.0572710860045997 no 284 0.0570787159532883 321 5512909
SGTC_1934 st074720 32.6 µM 1.57817666027344 0.0574572568849847 no 285 0.0572625152984007 445 17250992
SGTC_331 k048-0133 24.5 µM 1.57764409169438 0.0575192304722918 no 286 0.0573236984948108 326 6813582
SGTC_137 0438-0332 85.389 µM 1.57611755436521 0.0576971609375196 no 287 0.0574993570901669 546 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_372 0155-0182 15.9 µM 1.57586075001286 0.0577271360788344 no 288 0.0575289491207214 405 771486
SGTC_1159 4092-0538 61.2 µM 1.5751641631485 0.0578085058969594 no 289 0.0576092784055565 414 717301
SGTC_2497 7-hydroxyflavone 100 µM 1.57457377738887 0.0578775407095293 no 290 0.0576774297921853 350 5281894
SGTC_1175 0741-0056 27.6 µM 1.56971421266661 0.0584482426713568 no 291 0.0582408066022251 441 765927
SGTC_765 1319-0117 244 µM 1.56807730385827 0.0586414713270836 no 292 0.0584315462789035 353 3487746 YGL099W LSG1
SGTC_1958 st076513 41.9 µM 1.56647516752891 0.0588310805295875 no 293 0.058618708820657 415 732122 YGL099W LSG1
SGTC_3116 9124943 49.47 µM 1.5614255584345 0.059431839317207 no 294 0.059211687678989 381 41905195 YPL160W CDC60
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 1.56113715368573 0.059466295861156 no 295 0.0592456967269795 358 229346 A bile salt which induces apoptosis.
SGTC_1415 3966-0071 78.1 µM 1.56105451172913 0.059476172218996 no 296 0.0592554447926098 371 2893185
SGTC_1035 k081-0041 55.2 µM 1.55499262616934 0.0602041271708306 no 297 0.05997391275201 407 731709
SGTC_3306 9127676 59.7925 µM 1.55479042526791 0.0602285285864984 no 298 0.0599979951067898 386 41905287
SGTC_3243 9134147 49.47 µM 1.55160514302351 0.0606139479052542 no 299 0.0603783659067842 353 24282180
SGTC_2149 5554786 194.827 µM 1.54956276925778 0.0608620886198423 no 300 0.060623247409062 441 745063 YPR165W RHO1
SGTC_1446 4239-0190 62 µM 1.54627231157859 0.0612635366458649 no 301 0.0610194080099854 448 1340085
SGTC_2627 acetyl isogambogic acid 100 µM 1.54610288698861 0.0612842629484106 no 302 0.0610398608419105 383 6857789 A caspase activator and apoptosis inducer.
SGTC_1342 1486-1464 234 µM 1.54549031337168 0.0613592469380651 no 303 0.0611138550669428 410 3253938
SGTC_676 falcarinol 140 µM 1.5353477118925 0.0626112287751988 no 304 0.0623492201072326 432 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_3235 9132602 49.47 µM 1.53518014537733 0.062632078804293 no 305 0.0623697919684361 437 4912240
SGTC_1803 st050068 52.4 µM 1.53446874506831 0.0627206574540821 no 306 0.0624571883385957 631 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_1164 k060-0068 93.7 µM 1.53425375565628 0.0627474456513402 no 307 0.0624836188222173 437 5963676
SGTC_2606 farnesol 9.78 µM 1.52821741664552 0.063503233559777 no 308 0.0632292829599339 416 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1779 st039427 55 µM 1.5268560904783 0.0636746553263988 no 309 0.0633984001538249 487 1124498
SGTC_1732 st034308 51.822 µM 1.52646119961872 0.0637244483246869 no 310 0.063447523165181 407 830119
SGTC_628 1636-0253 16 µM 1.52499725472689 0.0639093059596619 no 311 0.0636298911972793 431 4456143
SGTC_119 0121-0043 24.815 µM 1.52197320965374 0.0642924833490671 no 312 0.0640078967881315 611 1092378
SGTC_377 3970-0964 33.1 µM 1.51011029190704 0.0658128972922364 no 313 0.0655076418936832 518 16481235
SGTC_2262 9014885 67.46 µM 1.50125610067616 0.0669657481902888 no 314 0.0666446673394459 304 6457424
SGTC_254 nsc-64875 3.808 µM 1.49851400075428 0.067325930528284 no 315 0.0669998789067958 406 56993
SGTC_10 0279-0212 42.575 µM 1.49683225572103 0.067547572099882 no 316 0.0672184554919664 559 39851 YBR002C RER2
SGTC_1775 st081588 35.1725 µM 1.49358300300816 0.0679773961165243 no 317 0.0676423223523049 464 1426443 YGL099W LSG1
SGTC_2828 7998861 71.43 µM 1.49081227895709 0.0683455840580497 no 318 0.068005393536443 337 2988188
SGTC_951 1171-0579 82.7 µM 1.48426219155953 0.0692221107097895 no 319 0.0688696882318807 522 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_454 lyso-paf C-16 6.67 µM 1.48416947005395 0.0692345804936883 no 320 0.0688819834889997 415 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_597 k018-0003 82.8 µM 1.4833904768569 0.0693394128621833 no 321 0.0689853480643552 455 6786234
SGTC_3153 9100258 49.47 µM 1.48331609501684 0.0693494291285168 no 322 0.0689952240370678 422 25236848
SGTC_1930 st074634 34.3 µM 1.48034187404016 0.0697508519684175 no 323 0.0693910168065797 447 684253 YOR116C RPO31
SGTC_2320 7373003 200 µM 1.47862836309103 0.0699829307465821 no 324 0.0696198339617136 414 5415828
SGTC_1380 2291-0730 164 µM 1.47184210016668 0.0709079051041716 no 325 0.0705317609401856 407 2999191
SGTC_1439 4092-1168 46 µM 1.46682738074014 0.0715974290327577 no 326 0.0712115096213773 422 2886240
SGTC_772 k072-0172 35.3 µM 1.459699416041 0.072586362251298 no 327 0.0721863512374557 395 5861980
SGTC_1290 0986-0249 10.2 µM 1.45933637146118 0.0726370096366205 no 328 0.0722362746892431 399 53329
SGTC_1906 st060206 94.7 µM 1.45873662819492 0.0727207375071069 no 329 0.0723188053115438 468 5133468
SGTC_166 k072-0058 166.424 µM 1.45668460902071 0.0730077711500579 no 330 0.0726017300981935 450 5846229
SGTC_94 0334-0113 514.748 µM 1.45567628672634 0.0731491312414217 no 331 0.0727410640942012 441 6795178
SGTC_1482 3346-2049 8.48 µM 1.45440392494792 0.0733278066752427 no 332 0.0729171762089438 438 3826804
SGTC_1731 st035964 63 µM 1.45436805406493 0.0733328487919163 no 333 0.0729221459516591 449 6739575
SGTC_1653 st012112 65 µM 1.45058084540524 0.073866683464981 no 334 0.0734483061056826 422 720429
SGTC_1706 st031321 9.9705 µM 1.43230534425117 0.0764845736448431 no 335 0.0760282271494921 437 6103185
SGTC_57 miconazole 162.5 nM 1.43129943707116 0.0766306892550107 no 336 0.0761722076026095 437 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1317 1273-0028 910 nM 1.43120196757444 0.0766448587094604 no 337 0.0761861699139952 450 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_491 tetrandrine 80.3 µM 1.42965800301813 0.0768695756600349 no 338 0.0764075996618749 393 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_805 3852-0218 479 µM 1.42629154461554 0.0773612844427504 no 339 0.0768921021330476 476 6615355
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.42626268005818 0.0773655107389675 no 340 0.0768962664102501 434 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2039 Aminomethylbenzodioxan 200 µM 1.42508883140897 0.0775375321574054 no 341 0.077065762340975 398 15053
SGTC_2651 TUB2.036 5 µM 1.42274735418103 0.0778815307277893 no 342 0.0774047038786225 666 15992207 YFL037W TUB2
SGTC_556 4058-0063 51.5 µM 1.41877268611163 0.0784681197252704 no 343 0.0779826491273996 510 6615692
SGTC_2727 riluzole 51.77 µM 1.41329091176496 0.0792826174900786 no 344 0.0787851025483848 408 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1129 3453-1384 223 µM 1.4132312976246 0.0792915101771748 no 345 0.078793863467245 524 1084452
SGTC_310 1273-0058 1.06 µM 1.40542771401489 0.0804621071764521 no 346 0.0799470652197434 718 2734232
SGTC_2945 9067681 61.76 µM 1.40468459433274 0.0805742580899279 no 347 0.080057544412499 432 16456930
SGTC_681 1642-0006 26.6 µM 1.40266838453142 0.0808791372913637 no 348 0.0803578745955343 410 4446530
SGTC_21 0849-0113 22.993 µM 1.39984183912973 0.0813080158031613 no 349 0.0807803428819222 499 1560156
SGTC_201 4262-0159 12.803 µM 1.3973498074596 0.0816875588608443 no 350 0.0811542024215064 410 1341029
SGTC_2138 5575593 77.673 µM 1.38781181742336 0.0831525646085086 no 351 0.0825971776930541 410 762213
SGTC_3149 9097855 49.47 µM 1.38602529677223 0.0834291520297452 no 352 0.0828695895999926 474 25236625 YMR079W SEC14
SGTC_2976 9009005 19.48 µM 1.38007253126233 0.0843557445629948 no 353 0.0837821569102565 480 2993148
SGTC_346 4513-0042 7.16 µM 1.379579756605 0.0844327933511207 no 354 0.0838580369271141 522 2827372
SGTC_761 k216-0224 480 µM 1.37923165929207 0.084487252633072 no 355 0.0839116698704266 520 1340404
SGTC_3299 9121982 43.1275 µM 1.37517479102824 0.0851238878397096 no 356 0.0845386308538891 500 17594604 YPL160W CDC60
SGTC_1575 cyproterone acetate 48 µM 1.37366049917625 0.0853624414014317 no 357 0.0847735526801015 495 9880 An androgen receptor antagonist and liver toxin.
SGTC_1734 st037168 69.4 µM 1.37356022960618 0.0853782550011902 no 358 0.0847891254054723 492 708907
SGTC_2017 5132927 60.65 µM 1.36599703912425 0.0865773872906463 no 359 0.0859699463642578 504 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_207 4185-0010 4.486 µM 1.36503845517539 0.0867302638068486 no 360 0.0861204819164124 585 3761753
SGTC_831 k061-1017 217 µM 1.36489055108036 0.0867538697440657 no 361 0.0861437262521321 675 1240153
SGTC_1812 st052057 4.327 µM 1.36187885783011 0.0872355898282215 no 362 0.0866180597263235 522 3645418
SGTC_1617 st002906 78 µM 1.35863354200832 0.087756910372173 no 363 0.0871313704316821 535 5150859
SGTC_181 1447-1644 8.07 µM 1.35833903458629 0.0878043341856266 no 364 0.0871780647818996 499 534600
SGTC_2820 7989630 71.43 µM 1.35774046391394 0.0879007794689801 no 365 0.08727302614452 411 2984098
SGTC_81 0411-0046 9.971 µM 1.35723759364978 0.087981865981013 no 366 0.0873528646135811 467 12925265
SGTC_2047 4141938 200 µM 1.35585965983686 0.088204339998653 no 367 0.0875719123901921 438 3807862
SGTC_1177 0983-0204 23.6 µM 1.35110531766099 0.0889751709061282 no 368 0.0883308491461049 550 766818
SGTC_1424 4048-1941 275 µM 1.33976331618546 0.0908343045574568 no 369 0.090161152716441 544 X1424
SGTC_914 3820-6779 408 µM 1.33919819938335 0.0909276843769164 no 370 0.0902530792368119 495 2893481
SGTC_2748 diazoxide 86.69 µM 1.33880239671766 0.0909931291478806 no 371 0.0903175051764207 448 3019 A potassium channel activatior.
SGTC_412 gemfibrozil 100 µM 1.33722429010265 0.091254411694241 no 372 0.09057471771918 443 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_684 1140-0066 328 µM 1.33668851137735 0.0913432453991591 no 373 0.0906621667848613 580 6813534
SGTC_2692 st077426 47.7 µM 1.33560205711522 0.0915235795240558 no 374 0.0908396887054207 529 25238571
SGTC_1668 st014914 51.6 µM 1.33473386746518 0.091667874756333 no 375 0.0909817324299233 482 2839556
SGTC_867 0518-0118 155 µM 1.3252094721787 0.09326193385138 no 376 0.0925508422790478 527 6848158
SGTC_2473 5854593 8.94 µM 1.32488991619642 0.0933157695253339 no 377 0.0926038329352992 490 2872951
SGTC_34 0469-0683 81.75 µM 1.32212436673479 0.0937826417719143 no 378 0.0930633705249923 514 3690923
SGTC_1848 st056003 16.4 µM 1.31798232450567 0.0944851115002301 no 379 0.09375478247921 560 146492
SGTC_1120 ficusin 1.78878 µM 1.31581553312046 0.0948541304728162 no 380 0.0941179822239926 545 6199 A DNA cross-linker.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.31551270526655 0.0949057885311528 no 381 0.0941688250960843 520 4330530
SGTC_2565 isoliquiritigenin 100 µM 1.31480602166994 0.0950264191639472 no 382 0.0942875515858625 429 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_633 0437-0093 97.7 µM 1.31475998828402 0.0950342809625236 no 383 0.0942952892604827 502 2831118
SGTC_1443 4112-3303 14 µM 1.31472665698214 0.0950399737383636 no 384 0.0943008921554156 554 704433
SGTC_1390 3413-2614 145 µM 1.31394939639468 0.0951727961698716 no 385 0.0944316170314062 567 3421432
SGTC_1044 1222-0021 1.78 µM 1.31289262984377 0.0953536012709447 no 386 0.094609565360666 539 4306703
SGTC_3267 9137951 49.47 µM 1.30908072270697 0.096007892129321 no 387 0.0952535042137408 462 16643986
SGTC_1809 st050081 57.6 µM 1.30667128950814 0.0964231561420637 no 388 0.0956621867364834 528 5036894
SGTC_12 0849-0099 9.267 µM 1.30330107983027 0.0970062213012137 no 389 0.0962359962990663 523 6071388
SGTC_108 0509-0257 621.132 µM 1.3021146461103 0.0972120956856052 no 390 0.0964385985763552 588 536624
SGTC_1696 st025591 34.7925 µM 1.30117656150805 0.0973751024407969 no 391 0.0965990130606635 562 2787147
SGTC_171 k064-0041 9.68 µM 1.29931361167614 0.0976994132103294 no 392 0.0969181624714952 448 53325
SGTC_2841 9004761 38.96 µM 1.29593646344806 0.0982893402789324 no 393 0.0974986877437698 488 2991039
SGTC_949 1165-0505 146 µM 1.29516865205868 0.0984238263779632 no 394 0.0976310281429304 588 6244267
SGTC_790 1575-0012 79.1 µM 1.29419258300083 0.0985949843311951 no 395 0.0977994540416471 563 378741 YLR208W SEC13
SGTC_2746 daunorubicin 9.88 µM 1.293517197751 0.0987135435464632 no 396 0.0979161199667446 377 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1782 st039423 80.636 µM 1.29256724542882 0.0988804776567081 no 397 0.0980803871379173 514 2068169
SGTC_2837 9008476 45.46 µM 1.29122775957606 0.0991162149056361 no 398 0.0983123559810189 574 2992805
SGTC_3151 9099821 49.47 µM 1.28904491610179 0.0995012556360028 no 399 0.0986912359178233 512 17174189
SGTC_204 PMA1.184 62.41 µM 1.2881167962086 0.0996653013348518 no 400 0.0988526546966656 605 2252213 YGL008C PMA1
SGTC_709 3807-1509 243 µM 1.28791500703937 0.0997009938190735 no 401 0.0988877754571413 524 1886677 YPL242C IQG1
SGTC_2952 9073731 13.78 µM 1.28578546869948 0.100078236188475 no 402 0.0992589714912082 586 16457353
SGTC_228 caffeine 993.056 µM 1.28371880173377 0.100445336511707 no 403 0.0996201816640525 498 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_3117 9124945 49.47 µM 1.28329418109585 0.100520883043355 no 404 0.0996945152713615 475 17592065
SGTC_1191 1487-1166 10.6 µM 1.28300257511117 0.100572788229709 no 405 0.0997455869501543 648 3955771
SGTC_67 0335-0847 266 µM 1.28198512170085 0.100754045689408 no 406 0.0999239327545351 711 4552207 YOR254C SEC63
SGTC_1247 0448-0043 5.84 µM 1.28189259529417 0.100770540908982 no 407 0.0999401629257375 596 3089013 YGL099W LSG1
SGTC_639 0833-0042 114 µM 1.28015508359582 0.101080663016096 no 408 0.100245299609314 594 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1354 1498-1681 81 µM 1.27895997959993 0.101294376168005 no 409 0.100455574620872 602 5754243
SGTC_2975 9084847 53.72 µM 1.27783659618802 0.101495563958715 no 410 0.100653523878435 571 27211724
SGTC_2 0422-0095 29 µM 1.27603091417899 0.101819554843782 no 411 0.10097229561543 448 6790840
SGTC_907 3448-6986 75.5 µM 1.27474140469415 0.102051389993314 no 412 0.101200393250914 620 590582
SGTC_1299 1079-1439 3.74 µM 1.27430443967194 0.102130037044761 no 413 0.101277771852986 545 323161
SGTC_3061 glucosamine 200 µM 1.26969008171631 0.102963243907986 no 414 0.102097523574275 541 91431 and experimental redox chemotherapeutic
SGTC_2825 7998094 58.44 µM 1.26896512669264 0.103094595396689 no 415 0.1022267511255 549 2987815
SGTC_2564 betulinic acid 100 µM 1.2684914623065 0.103180482323046 no 416 0.102311248862646 622 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_848 0368-0089 85.6 µM 1.26692092558766 0.103465630743551 no 417 0.102591782806938 587 762535
SGTC_3332 9141069 11.198 µM 1.26162263261347 0.104431813611475 no 418 0.103542304104436 507 17332883
SGTC_332 4112-0506 40.9 µM 1.26144213702977 0.104464843077911 no 419 0.10357479746568 577 2790355
SGTC_1600 coumarin 106 71.1 µM 1.26107166517959 0.104532660621209 no 420 0.103641514109132 608 100336 A hepatotoxic, DNA x-linker.
SGTC_2459 5811157 9.22 µM 1.2607931761644 0.10458366103904 no 421 0.103691686495338 552 2870684 YBR192W RIM2
SGTC_445 e6 berbamine 66 µM 1.26051433552681 0.104634743906912 no 422 0.103741939882449 700 6610268 A calcium/calmodulin antagonist.
SGTC_2353 9059630 146.67 µM 1.25836509516393 0.10502908565153 no 423 0.104129874618888 548 4779114
SGTC_1449 4112-4002 201 µM 1.25373307511275 0.105882621894184 no 424 0.104969520874741 555 2059539
SGTC_2956 9076196 2.52 µM 1.25306083661824 0.106006909790086 no 425 0.105091783658458 596 16423868
SGTC_393 acivicin 6.25 µM 1.25256367014663 0.106098897002168 no 426 0.105182271647533 533 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2731 amoxapine 43.43 µM 1.25232012397338 0.1061439796745 no 427 0.105226619428068 448 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3143 9086658 49.47 µM 1.25211716996171 0.106181558928186 no 428 0.10526358603936 657 25236626
SGTC_1494 4358-1428 177 µM 1.24681115172811 0.107167441200417 no 429 0.106233375261927 602 1564571
SGTC_1072 oxiconazole 14.9 nM 1.2462913202081 0.107264382114331 no 430 0.106328731641833 612 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_892 0929-0076 29 µM 1.2402558098373 0.108394546780851 no 431 0.107440395801827 635 5751038
SGTC_481 bay k-8644 50 µM 1.23707837226462 0.108992961276115 no 432 0.108028994112975 555 2303 A calcium channel antagonist.
SGTC_975 1335-0046 28.5 µM 1.23542526745084 0.109305231943172 no 433 0.108336136901888 581 16486740
SGTC_446 go6976 132 µM 1.22990329631235 0.110352987537316 no 434 0.109366659857937 563 3501 A protein kinase C inhibitor.
SGTC_3099 9120367 49.47 µM 1.22889803725297 0.110544500741217 no 435 0.109555018731739 585 24824940
SGTC_596 1155-0152 116 µM 1.22783523805212 0.110747234958303 no 436 0.109754412310548 654 280313
SGTC_3333 9141820 12.094 µM 1.22753863832628 0.110803860347797 no 437 0.109810104358158 539 1939433
SGTC_3320 9137005 35.139 µM 1.22657487040918 0.110988001482531 no 438 0.109991209519218 566 4908713
SGTC_2346 9031566 143.75 µM 1.22449829035484 0.111385505393155 no 439 0.110382155430818 580 4771086
SGTC_259 usnic acid 108.925 µM 1.22280342285026 0.111710695416423 no 440 0.110701976175273 616 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3139 9095020 49.47 µM 1.22078269439901 0.112099294429124 no 441 0.111084153903064 462 25236292
SGTC_1197 1601-0112 267 µM 1.21887473033747 0.112467094182035 no 442 0.111445871038738 639 7350313
SGTC_2199 6590217 200 µM 1.21317765279909 0.113570452313349 no 443 0.112530953077286 534 703109
SGTC_2883 9059145 45.46 µM 1.2112940435538 0.11393694470007 no 444 0.112891365389241 571 16476510
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.20793775506934 0.114592062094185 no 445 0.113535602857039 533 61125 An anti-inflammatory.
SGTC_163 TUB2.036 7.546 µM 1.20776421473258 0.11462600835192 no 446 0.113568984946997 791 15992207 YJR013W GPI14
SGTC_1778 st046819 58.9 µM 1.20664016206909 0.114846057806251 no 447 0.113785376348527 662 671715
SGTC_1097 itavastatin 7.23 µM 1.20653896789302 0.1148658827542 no 448 0.113804871649958 632 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3251 9135047 49.47 µM 1.20338089856572 0.115485803881304 no 449 0.114414478097957 549 17682963
SGTC_571 k831-0106 44.2 µM 1.20312202370059 0.11553672559335 no 450 0.114464551963564 579 4783639
SGTC_532 1548-0774 215 µM 1.20291201707809 0.115578046446781 no 451 0.11450518476095 650 5932993
SGTC_3040 9091894 49.47 µM 1.19551802651433 0.117039583687393 no 452 0.115942348743165 549 25236966
SGTC_1116 jasmonic acid 1.58368 µM 1.19465409389293 0.117211204108191 no 453 0.116111102554593 628 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1047 2043-3044 82 µM 1.18788261787943 0.118562535451292 no 454 0.117439829374523 644 669592
SGTC_1077 5-fluorocytosine 377 nM 1.18699168627583 0.118741148075081 no 455 0.117615449914774 600 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1410 3909-8106 77.9 µM 1.18527520296114 0.119085801774157 no 456 0.117954327228287 616 1039210
SGTC_3154 9100113 49.47 µM 1.18484090018305 0.119173117531806 no 457 0.118040178990469 627 25237525
SGTC_128 0906-2981 13.371 µM 1.18311686395884 0.119520177519597 no 458 0.118381417605257 567 6740226
SGTC_1681 tripelennamine 100 µM 1.17787617349325 0.120579539342696 no 459 0.119422987573494 557 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1757 st041620 31.8375 µM 1.17122896776097 0.121932704107534 no 460 0.120753377225491 656 5289815
SGTC_612 0302-0167 22.4 µM 1.16993094945031 0.122198180305476 no 461 0.121014378887991 715 235821
SGTC_1051 3253-3903 78 µM 1.16958431150081 0.122269144769315 no 462 0.121084146917416 668 5509239
SGTC_879 0831-1030 162 µM 1.16942530308073 0.122301706990853 no 463 0.121116160103317 700 1549252
SGTC_339 3091-4833 71.4 µM 1.1689966385971 0.122389520513334 no 464 0.121202492838614 657 3240077
SGTC_215 1287-0124 461.5 µM 1.16891585986598 0.12240607329229 no 465 0.121218766465462 590 5560863
SGTC_220 paclitaxel 373.376 µM 1.16767658430601 0.122660216487125 no 466 0.121468622707575 574 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2605 digitonin 300 nM 1.16482710262041 0.123245974437477 no 467 0.122044492914134 741 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2108 5365811 200 µM 1.1646248600925 0.123287623096817 no 468 0.122085438162641 653 780283
SGTC_2101 5377231 179.231 µM 1.15985757479287 0.124272227383054 no 469 0.123053399143592 644 2844213
SGTC_599 1935-0052 86.5 µM 1.15888373791222 0.12447403199143 no 470 0.123251789212351 680 9557311
SGTC_1969 st069479 40.1 µM 1.1564182182875 0.124985976526093 no 471 0.123755066620217 608 3895485
SGTC_2134 5324836 1.464 µM 1.15098815955112 0.126118664660335 no 472 0.124868553361417 589 699272
SGTC_555 4296-0685 37 µM 1.15020847110211 0.126281890150321 no 473 0.125029009022414 671 2908540 YHR072W ERG7
SGTC_804 1595-0054 20.9 µM 1.14979615804438 0.12636826616574 no 474 0.125113919009251 616 761523 Stimulates phospholipase C.
SGTC_130 0136-0219 337.655 µM 1.14756124053739 0.126837178339355 no 475 0.12557486909023 692 234244
SGTC_2888 9058547 12.99 µM 1.14728891629557 0.126894397880071 no 476 0.125631116654277 564 16476514
SGTC_1980 st071811 45.7 µM 1.14546946917685 0.127277152983911 no 477 0.126007367790665 647 4974850
SGTC_197 4544-0043 41.561 µM 1.14532502115539 0.127307574731617 no 478 0.126037272434251 694 896523
SGTC_499 genistein 192 µM 1.144599751945 0.127460397873196 no 479 0.12618749755153 630 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1649 st011737 51.3 µM 1.14449669699691 0.127482123165298 no 480 0.126208853460551 653 1761035
SGTC_1878 temozolomide 1 mM 1.1443919809314 0.127504201279527 no 481 0.126230556180453 631 5394 DNA alkylating agent.
SGTC_1709 st033179 39.1045 µM 1.14320372415144 0.127754917100993 no 482 0.126477008203657 689 573381
SGTC_1245 0418-0076 17.2 µM 1.14149418698673 0.128116221056106 no 483 0.126832164827014 677 6790114
SGTC_398 bronopol 33.3 µM 1.14066918318875 0.128290836023163 no 484 0.127003807658952 671 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1277 0873-0036 22 µM 1.13857320524488 0.128735200146837 no 485 0.127440604770104 717 5965735
SGTC_713 1488-1073 324 µM 1.13361432290141 0.129790771368951 no 486 0.128478181187405 691 3312542
SGTC_750 4073-0104 132 µM 1.13351718795672 0.129811507649634 no 487 0.128498563693734 567 22330957
SGTC_1231 0242-0792 125 µM 1.13222292845509 0.130088023936292 no 488 0.128770361437162 661 3707635
SGTC_1450 4112-4260 37.6 µM 1.13172794256116 0.130193884497317 no 489 0.128874415077789 706 1633175
SGTC_3225 9130819 49.47 µM 1.13047697190772 0.130461689991303 no 490 0.129137648230678 681 4547121
SGTC_615 k087-0205 167 µM 1.12711782460903 0.13118269424855 no 491 0.129846334019493 650 9642773
SGTC_2075 5212009 200 µM 1.1268307294926 0.131244443492884 no 492 0.129907027697071 597 780898
SGTC_670 4204-0025 119 µM 1.12316690242258 0.13203423286642 no 493 0.130683308236741 714 719039
SGTC_2909 7941780 10.49 µM 1.12049838841309 0.132611527474225 no 494 0.131250719485368 709 1243215
SGTC_2156 5649887 115 µM 1.1186598650598 0.133010275806425 no 495 0.131642636764541 774 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1841 st054148 70 µM 1.11836861958556 0.133073518263181 no 496 0.131704795469896 636 675442
SGTC_1065 prochlorperazine maleate 2.48 µM 1.11695638892787 0.133380470365499 no 497 0.132006486227351 705 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_2495 cafestol 54.53 µM 1.11630730166875 0.133521714464367 no 498 0.13214530860974 640 16667697 An anti-infammatory.
SGTC_906 1165-0455 526 µM 1.11533378198071 0.133733749193426 no 499 0.132353707041409 672 3252859
SGTC_818 4072-2707 53.5 µM 1.11415493902251 0.133990813493549 no 500 0.132606361474693 671 882871
SGTC_3028 9087778 49.47 µM 1.11014557989222 0.134867654252428 no 501 0.133468149401057 676 17217395
SGTC_3078 9116413 49.47 µM 1.10539553377949 0.135911566448152 no 502 0.134494119089614 638 17177322
SGTC_1465 k213-0056 144 µM 1.10496407725773 0.136006660501324 no 503 0.134587577545175 684 24048857 YMR208W ERG12
SGTC_2707 st078556 66.6 µM 1.10339983527557 0.136351805053079 no 504 0.134926784097951 699 17250899
SGTC_1588 farnesol 29.9 µM 1.10199167740245 0.13666302229619 no 505 0.135232644922069 718 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_19 0279-0214 38.434 µM 1.10179546961387 0.136706424739245 no 506 0.135275300198756 794 3566274 YBR002C RER2
SGTC_2395 5646831 180.19 µM 1.10091951826311 0.136900305839263 no 507 0.135465843193368 720 6808628
SGTC_981 1488-1094 54.9 µM 1.10075637737053 0.136936435826469 no 508 0.135501351035332 637 3449522
SGTC_3111 9122088 49.47 µM 1.09814571377928 0.137515492831928 no 509 0.13607043326671 577 16876704
SGTC_2937 9044753 11.33 µM 1.0964183483076 0.137899547962314 no 510 0.136447868974003 737 6465530 YGL099W LSG1
SGTC_2671 danthron 100 µM 1.09457845197726 0.138309426780966 no 511 0.136850680038519 707 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1337 1486-1011 40.3 µM 1.09433399786592 0.138363946936529 no 512 0.13690425982402 706 X1337
SGTC_3275 9138069 49.47 µM 1.09165834660763 0.138961650195556 no 513 0.137491650003109 682 17617007
SGTC_125 0133-0007 11.75 µM 1.09119860456187 0.139064526879581 no 514 0.137592750897432 768 26541
SGTC_952 1185-0122 232 µM 1.09098991869326 0.139111241713364 no 515 0.137638659302789 698 678600
SGTC_796 1234-0020 70.7 µM 1.09076632220049 0.139161306178055 no 516 0.137687859468237 680 46495034
SGTC_333 3486-0131 40.1 µM 1.08992405001693 0.139350005565425 no 517 0.137873300766458 749 6744690
SGTC_1316 1272-0050 65.9 µM 1.08580958867088 0.140274295062007 no 518 0.138781621631991 714 7340392
SGTC_893 0958-0369 48.9 µM 1.08509146268841 0.140436043639548 no 519 0.138940574076364 748 6819948
SGTC_1949 st076024 69.1 µM 1.08494064244186 0.140470030031014 no 520 0.138973972885919 685 2921930
SGTC_1497 4476-2978 41.3 µM 1.0832718941209 0.140846444642013 no 521 0.139343878324899 780 1528379
SGTC_930 2810-3379 265 µM 1.08155065084165 0.141235416723347 no 522 0.139726121332554 809 1015764
SGTC_2131 toluylene red 5.2905 µM 1.08120828893558 0.141312871515812 no 523 0.139802235854296 699 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1255 0566-0045 221 µM 1.07975566504196 0.141641828419672 no 524 0.140125499299986 722 2788469
SGTC_698 k064-0052 127 µM 1.0796879588975 0.141657173595175 no 525 0.140140578839216 709 5088751
SGTC_1651 st011928 86.1 µM 1.0777650833765 0.142093451531906 no 526 0.140569302708408 725 720198
SGTC_2098 5376439 882.5 nM 1.07467627343602 0.142796168368108 no 527 0.141259844999872 763 2844116
SGTC_1109 tnp00067 928.257 nM 1.07328379249527 0.143113730391564 no 528 0.141571902419523 735 676295
SGTC_1513 0337-0559 19 µM 1.07075186772555 0.143692369695635 no 529 0.142140507118693 650 775073
SGTC_631 k072-0230 41.5 µM 1.07004257613295 0.143854751993352 no 530 0.142300072392477 781 5773147
SGTC_550 4123-0385 25.7 µM 1.06968496306914 0.143936669380022 no 531 0.142380568497574 712 5731123
SGTC_293 4049-0273 38.5 µM 1.06848807080763 0.144211066861992 no 532 0.142650204302926 690 1380311
SGTC_2874 9043904 71.43 µM 1.06676355952822 0.144607045121985 no 533 0.143039308830741 631 4463428
SGTC_2917 7979103 53.79 µM 1.06605030767833 0.144771034268124 no 534 0.143200450543189 786 2980565
SGTC_1474 0330-0125 5.35 µM 1.06505979402802 0.144998978434617 no 535 0.143424436047399 743 X1474
SGTC_3098 9119039 49.47 µM 1.06324936953772 0.145416230459032 no 536 0.143834439516016 735 17161528
SGTC_387 norethindrone acetate 66.7 µM 1.06203347142734 0.145696913749061 no 537 0.144110245137799 696 541197
SGTC_3173 9105693 49.47 µM 1.06180270764334 0.145750225374649 no 538 0.144162630178087 752 17096658
SGTC_3179 9107801 49.47 µM 1.06010024439688 0.146143937874726 no 539 0.14454949831928 732 4818259
SGTC_1425 4048-4433 7.33 µM 1.05807662670471 0.146612849120731 no 540 0.145010254704926 797 23734946
SGTC_1438 4092-1045 4 µM 1.05737978079131 0.146774555213455 no 541 0.145169147750709 755 1351342
SGTC_3348 9149464 3.537 µM 1.05524506585834 0.147270669491997 no 542 0.145656629043939 731 1951442
SGTC_3289 9119912 71.43 µM 1.05240368797259 0.147932756173066 no 543 0.146307188685731 732 17014829
SGTC_3059 1327-0034 3 µM 1.04764057972617 0.149047100257297 no 544 0.147402116864583 743 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1716 st033144 30.6155 µM 1.04725055718952 0.149138594971562 no 545 0.147492016589511 783 674617
SGTC_1090 efavirenz 20.7 µM 1.04638662215196 0.14934139755002 no 546 0.147691283357149 755 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2689 tacrolimus 100 µM 1.0458272737757 0.149472798730431 no 547 0.147820393271025 721 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_3349 9149703 23.001 µM 1.04428336037179 0.149835892625261 no 548 0.148177154528512 728 4910494
SGTC_663 1486-0733 13.9 µM 1.04171522338671 0.150441163121932 no 549 0.148771864435869 785 722445 YPR165W RHO1
SGTC_2777 climbazole 1.536 µM 1.04041167685622 0.150749011430224 no 550 0.149074339502119 785 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_2386 9075165 157.42 µM 1.04034405680297 0.150764992160192 no 551 0.149090041265112 752 16452277
SGTC_3071 9117417 49.47 µM 1.03912194092228 0.151054010708587 no 552 0.149374013957886 661 45595590 YGL055W OLE1
SGTC_3220 9131269 49.47 µM 1.0380860573937 0.151299275617445 no 553 0.149614995978905 751 17722206
SGTC_3193 9111931 49.47 µM 1.03707467743835 0.151538994253389 no 554 0.149850527777535 756 17087244
SGTC_1127 asiatic acid 681.4 nM 1.03527261517385 0.151966746917816 no 555 0.150270807524887 735 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_3212 9128307 49.47 µM 1.03354063146991 0.152378620298719 no 556 0.150675483070716 649 27243542
SGTC_3132 9126706 49.47 µM 1.03334146236175 0.152426031048652 no 557 0.150722065132268 734 850858
SGTC_586 0957-0265 8.15 µM 1.03162497859816 0.152835033184272 no 558 0.151123917118933 680 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1814 st052110 31.539 µM 1.02956292816223 0.153327338073142 no 559 0.15160761265614 744 674163
SGTC_296 1222-0039 74.9 µM 1.02758032297714 0.15380166538414 no 560 0.152073642041438 716 5984176
SGTC_1461 k072-0203 53.8 µM 1.02526498351617 0.154356825696949 no 561 0.152619086694058 737 5418714
SGTC_1340 1486-1359 257 µM 1.02204692731197 0.155130632741219 no 562 0.153379345206121 771 4309068
SGTC_1745 st081495 74 µM 1.01718392102932 0.156304832173587 no 563 0.154532971779635 834 13842402 YBL026W LSM2
SGTC_1608 st001473 40.5 µM 1.01694467070809 0.156362751171899 no 564 0.154589875569743 749 7292267
SGTC_2858 9025781 8.96 µM 1.01630925278101 0.156516645160254 no 565 0.154741071903072 876 4894980 YPL153C RAD53
SGTC_1744 st037937 38.9 µM 1.01599390531278 0.156593057231695 no 566 0.154816144421276 765 1016152
SGTC_2951 9072950 58.06 µM 1.01424627172481 0.157016972699454 no 567 0.155232627148705 864 16488155
SGTC_1022 4477-0945 21.3 µM 1.01404813617397 0.157065081129699 no 568 0.155279891937148 775 4648966
SGTC_1951 sophoraflavanone G 9.2 µM 1.01203125939524 0.157555341763826 no 569 0.155761553733925 791 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2839 9003951 25.97 µM 1.00996916427446 0.158057632537138 no 570 0.156255031868184 769 2990634
SGTC_1264 0783-0040 158 µM 1.00822577003653 0.158483112422783 no 571 0.156673044571802 750 2855798
SGTC_2595 hexamethylquercetagetin 100 µM 1.00675473335809 0.158842706568111 no 572 0.15702632629423 734 386331
SGTC_552 k242-0005 476 µM 1.00604351964531 0.159016754017201 no 573 0.157197317962432 775 4088318
SGTC_2233 sulbentine 40.3845 µM 1.00507710218269 0.159253454830298 no 574 0.157429862460108 865 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_755 1995-0008 37.3 µM 1.00160241990747 0.160106400318852 no 575 0.158267825885439 826 689533
SGTC_2194 5927483 104.545 µM 1.00025839671025 0.160437123202732 no 576 0.15859273757032 847 760979
SGTC_46 0329-0187a 2.197 µM 1.00002624186218 0.160494294567276 no 577 0.158648904252367 888 46494817
SGTC_264 promethazine 12.5 mM 0.997554024470358 0.161103937961749 no 578 0.159247832232575 951 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_682 0kpi-0099 17 µM 0.994666113544168 0.161818001517588 no 579 0.159949340360602 830 1714895 YML126C ERG13
SGTC_1792 st045773 43.6 µM 0.994323750271917 0.161902790633756 no 580 0.160032638295259 779 2919270
SGTC_244 nsc-207895 1.295 µM 0.994043820484623 0.161972139081601 no 581 0.160100767064466 689 42640
SGTC_1029 k015-0030 64.7 µM 0.992504517592748 0.162353824202511 no 582 0.160475738407075 783 2208316
SGTC_1406 3909-7906 11.9 µM 0.991742363875186 0.162543024152487 no 583 0.160661609850435 824 X1406
SGTC_2301 7769476 200 µM 0.990899049838697 0.162752538773605 no 584 0.160867438187366 772 977820
SGTC_2980 9014342 25.29 µM 0.989756271968858 0.163036732939295 no 585 0.161146631476091 751 2996599
SGTC_3240 9133527 49.47 µM 0.989324220344222 0.163144262607061 no 586 0.161252268783615 787 17617455
SGTC_2571 chrysanthemic acid 100 µM 0.988359843767017 0.163384444337488 no 587 0.161488223296006 755 2743 An insecticide.
SGTC_2486 5283202 22.39 µM 0.986314791613482 0.163894532100604 no 588 0.161989331745673 762 1377751
SGTC_1707 st032323 6.317 µM 0.986004912248072 0.163971913918215 no 589 0.162065351172047 808 3132057 YMR211W DML1
SGTC_1515 3460-0031 42.1 µM 0.985924444902559 0.163992011773544 no 590 0.162085095174055 759 2876596
SGTC_1178 0988-0033 191 µM 0.982441850969944 0.164863370039611 no 591 0.162941108457991 822 5392207
SGTC_3058 9093861 49.47 µM 0.980616913649602 0.165321171476615 no 592 0.163390845210856 787 17217477
SGTC_3011 9081274 71.4286 µM 0.979077946508931 0.165707873519353 no 593 0.163770733697048 851 6625322
SGTC_1393 3470-5649 58.2 µM 0.979026243131309 0.165720875367176 no 594 0.163783506435295 707 4108395
SGTC_1859 st055998 20 µM 0.976076601825405 0.166463713715031 no 595 0.164513252713502 870 676301
SGTC_1320 1313-0481 95.3 µM 0.974705272802719 0.166809800423749 no 596 0.164853238346501 860 6813365 YLR208W SEC13
SGTC_1078 idebenone 36.1 µM 0.973805462063196 0.167037140592555 no 597 0.165076570280135 870 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_847 0342-0274 5.54 µM 0.973445633810695 0.167128108292286 no 598 0.165165934015388 869 18097
SGTC_1936 st074407 74.3 µM 0.972998585562189 0.167241170446073 no 599 0.165277002540728 859 809813
SGTC_624 k048-0052 28 µM 0.971188634850861 0.167699425506749 no 600 0.165727176173236 792 6835531
SGTC_3239 9133757 49.47 µM 0.970611965347175 0.167845600134973 no 601 0.165870772645245 848 17036923
SGTC_574 1315-0397 40 µM 0.970126611030019 0.167968691673352 no 602 0.16599169303142 946 6794277
SGTC_1554 st069299 38.7 µM 0.964797003254725 0.16932416307773 no 603 0.167323248606675 827 24207999
SGTC_2334 9017922 200 µM 0.96383615288112 0.169569279712025 no 604 0.16756403902724 858 3163164
SGTC_485 niflumic acid 177 µM 0.962721274311714 0.1698539746974 no 605 0.16784370873581 805 4488 A COX2 inhibitor.
SGTC_1349 flufenamic acid 69 µM 0.961926441856641 0.170057129849709 no 606 0.16804327756894 809 3371 A non-steroidal anti-inflammatory.
SGTC_1166 k206-0078 225 µM 0.960868806374741 0.170327697507584 no 607 0.168309068435981 864 5404595
SGTC_1618 st003135 44.5 µM 0.95995967071911 0.170560495743249 no 608 0.168537756298612 835 1270615
SGTC_1431 4049-0260 9.09 µM 0.958669963808165 0.170891094446722 no 609 0.168862517215959 860 3854841
SGTC_2111 5486399 200 µM 0.956403391822018 0.171473091867724 no 610 0.16943423588619 880 689674
SGTC_480 am 92016 50 µM 0.953870219891675 0.172125042423971 no 611 0.170074669717583 777 2129 K+ channel blocker.
SGTC_2914 7968218 45.32 µM 0.952800202052671 0.172400902522423 no 612 0.170345655958886 801 2977111
SGTC_383 2324-0395 7.37 µM 0.950437059798422 0.173011140120248 no 613 0.170945110360892 864 3146421
SGTC_2389 9091542 195.52 µM 0.949967925557826 0.173132448837136 no 614 0.171064275235147 866 3626624 YOL127W RPL25
SGTC_1232 0279-0259 161 µM 0.948294671988578 0.173565559752642 no 615 0.171489731262488 845 1560000
SGTC_1302 1159-0335 255 µM 0.947863758930858 0.173677210372126 no 616 0.171599408375628 830 649284
SGTC_1372 2752-0194 270 µM 0.944149133129647 0.174641572948948 no 617 0.172546722302139 799 823334
SGTC_150 3970-0969 77.2 µM 0.943338167425269 0.174852560933383 no 618 0.172753979638135 895 6615640
SGTC_3231 9132313 49.47 µM 0.942301005883896 0.175122633668647 no 619 0.173019276663577 863 4905967
SGTC_3074 9116018 49.47 µM 0.942104468703664 0.175173840973479 no 620 0.173069578424923 828 17027303
SGTC_3317 9138495 8.753 µM 0.942096623561021 0.175175885204224 no 621 0.173071586505474 859 17020139
SGTC_2765 myclobutanil 7.74 µM 0.941391444844069 0.175359697395957 no 622 0.173252148074344 844 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1468 k284-1086 134 µM 0.938597330489064 0.17608921405134 no 623 0.173968761953151 915 15996457
SGTC_169 k015-0017 16.025 µM 0.936886492782939 0.176536844427684 no 624 0.174408473933222 801 1840002
SGTC_1614 st002383 48.6 µM 0.936747215942235 0.176573317025884 no 625 0.174444301304766 856 1947235
SGTC_1442 4112-3290 3 µM 0.936368089058717 0.17667262359045 no 626 0.174541851033072 894 704353
SGTC_1838 st055369 84.5 µM 0.935030069680175 0.177023379737398 no 627 0.174886401577441 859 676036
SGTC_2827 7993847 71.43 µM 0.934900464984299 0.177057378420543 no 628 0.174919798723801 783 2985692
SGTC_3203 9113543 49.47 µM 0.932388718666176 0.177717089350769 no 629 0.175567836412106 824 17018012
SGTC_1042 0350-0096 82 µM 0.931897908805771 0.177846181609604 no 630 0.175694644229303 847 3122515
SGTC_1182 1222-0449 220 µM 0.930592804343566 0.178189736372661 no 631 0.176032119037288 850 658318
SGTC_1855 st056195 39.6 µM 0.929926844216639 0.178365204313726 no 632 0.176204481498692 842 4028379
SGTC_1648 st011736 69.8 µM 0.928534836701975 0.17873232351837 no 633 0.176565102921463 856 2855514
SGTC_1979 st071809 45.3 µM 0.927659584799409 0.178963400308923 no 634 0.176792089520268 896 4976333
SGTC_834 0312-0008 75.7 µM 0.927273421447225 0.179065411716744 no 635 0.176892295200988 895 6385573 YIL048W NEO1
SGTC_1753 st043925 64 µM 0.924797332445901 0.179720380444509 no 636 0.177535669230469 905 670181
SGTC_1790 st045711 43.5 µM 0.922913564838797 0.180219676646526 no 637 0.178026125488585 871 585119
SGTC_2413 inermin 26.06 µM 0.920972992443803 0.180734938504715 no 638 0.178532263810928 909 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_2934 9036370 36.88 µM 0.918232812191781 0.181464083798008 no 639 0.179248496896265 916 6462800
SGTC_1419 3993-2473 62.6 µM 0.91663478199608 0.181890158773119 no 640 0.179667025855824 907 704026
SGTC_1333 1482-0047 286 µM 0.914671549334292 0.18241446163578 no 641 0.180182042280013 940 3811116
SGTC_2755 lomerizine 42.69 µM 0.912464207376831 0.183005082902074 no 642 0.180762201530409 910 3949 A calcium channel blocker.
SGTC_2536 dehydroabietamide 32.04 µM 0.910116285801252 0.183634627233636 no 643 0.181380593338941 929 3983547
SGTC_970 1315-0089 19.5 µM 0.907883816863143 0.184234465397502 no 644 0.181969804297352 853 6811083 YLR033W RSC58
SGTC_297 0986-0032 24 µM 0.906560135742553 0.1845906981179 no 645 0.182319725312758 876 2847425
SGTC_695 3505-6186 243 µM 0.905620765667059 0.184843763655264 no 646 0.182568306878976 899 1819379
SGTC_2292 7671323 168.05 µM 0.905531065622781 0.184867940047784 no 647 0.182592054891883 884 937504
SGTC_2002 4023503 131 µM 0.904695158295817 0.1850933323385 no 648 0.182813453413504 1010 4736863 YCR052W RSC6
SGTC_3023 9089636 49.47 µM 0.904314153296661 0.185196122334803 no 649 0.182914422018379 971 17249241
SGTC_76 0433-0009 400.328 µM 0.903077055223823 0.18553011903166 no 650 0.183242500297113 805 2841569
SGTC_749 1000-0129 128 µM 0.902476994112656 0.185692260491466 no 651 0.183401768531232 964 708470
SGTC_2784 7567673 72.73 µM 0.902242930944901 0.185755530115506 no 652 0.18346391697278 939 3471247
SGTC_3295 9122362 53.5725 µM 0.89829069015295 0.186825878877081 no 653 0.18451529728668 859 4730473
SGTC_1262 0737-0114 49.6 µM 0.89585667165144 0.187486956866238 no 654 0.185164658868818 970 765919
SGTC_1927 st060202 13.8 µM 0.894852670943821 0.187760063492797 no 655 0.185432924987989 917 688887
SGTC_1724 st037281 8.293 µM 0.894528811096345 0.18784821170561 no 656 0.185519510851001 892 574124 YDL195W SEC31
SGTC_2950 9072895 21.46 µM 0.894223656464486 0.187931292110592 no 657 0.185601118719097 944 17332245
SGTC_1100 amiodarone 5.07 µM 0.893524451692686 0.188121740850204 no 658 0.185788191865835 975 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_77 0828-0286 12.516 µM 0.892608517663307 0.188371402246777 no 659 0.18603342809053 949 745345
SGTC_591 4299-0174 154 µM 0.892265194688712 0.188465036398411 no 660 0.18612540258602 920 5509088
SGTC_1281 0884-0031 11.8 µM 0.891310966660695 0.188725432831349 no 661 0.186381183464516 919 1548255
SGTC_1467 k284-1082 293 µM 0.890489724874662 0.188949716508183 no 662 0.18660149162945 948 3334705
SGTC_3038 9091290 49.47 µM 0.889745113301939 0.189153214112225 no 663 0.18680138211726 903 25236843
SGTC_696 1560-0013 611 µM 0.88939482208691 0.189248993133841 no 664 0.186895463384464 921 1650269
SGTC_1366 1683-0113 21.9 µM 0.888062218674566 0.189613635467455 no 665 0.18725364208328 920 708623
SGTC_1375 2910-0797 186 µM 0.885213922281037 0.190394467157088 no 666 0.18802063241684 915 742508
SGTC_469 w7 172 µM 0.885152593121011 0.190411301615846 no 667 0.188037168455999 913 45115570 A P450 inhibitor.
SGTC_172 1112-0046 2.638 µM 0.885027692138009 0.19044558895627 no 668 0.188070847994061 842 2802135 YIL048W NEO1
SGTC_2071 5230951 39.92 µM 0.883988647751047 0.190730970388483 no 669 0.188351170519459 1009 1799272
SGTC_2349 9023730 187.07 µM 0.883254660122905 0.190932723753874 no 670 0.188549347410568 922 4126287
SGTC_2743 auranofin 4.32 µM 0.883034291819445 0.19099332258909 no 671 0.188608872008448 911 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2889 9059656 51.95 µM 0.879529755394184 0.191958616016856 no 672 0.189557053451605 974 3949838
SGTC_887 0885-0007 9.62 µM 0.878742342415039 0.19217591205358 no 673 0.189770497392572 954 5719458
SGTC_921 1561-0023 372 µM 0.878536421552796 0.192232763193022 no 674 0.18982634070718 971 24050882
SGTC_1347 1493-0251 600 nM 0.878155296938845 0.192338012153216 no 675 0.189929723872083 995 3986378
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.877779655360983 0.19244178142896 no 676 0.190031653582202 924 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_300 r073-0011 5.04 µM 0.877336113163069 0.192564352002365 no 677 0.190152051289403 1001 2735780
SGTC_2033 5192550 145 µM 0.876855073078101 0.192697338848306 no 678 0.190282680613878 919 182073
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.875755036846515 0.193001662285008 no 679 0.190581609162337 966 688751
SGTC_3276 9139060 49.47 µM 0.873760805526534 0.193554111292012 no 680 0.191124264656405 930 4870619
SGTC_1845 st056753 3.01 µM 0.873244464305968 0.193697306998746 no 681 0.191264921876116 948 5375839
SGTC_1212 0520-0165 585 µM 0.873046614275324 0.193752193399511 no 682 0.191318835285129 913 5403258
SGTC_1399 3562-5772 25 µM 0.872253179885777 0.193972398577764 no 683 0.191535136811739 858 23847490
SGTC_375 3970-0961 9.27 µM 0.869001197942231 0.194876527143408 no 684 0.192423237769192 946 2898222
SGTC_998 3996-0085 177 µM 0.867662016479272 0.195249595340671 no 685 0.192789692653916 1006 715391
SGTC_2492 derrusnin 100 µM 0.866564413420091 0.195555688175742 no 686 0.193090359501975 875 1715307 Part of coumarin class of compounds.
SGTC_1172 0370-0043 85 µM 0.864360048396043 0.196171307634909 no 687 0.193695066327621 954 376585
SGTC_2063 5246145 200 µM 0.862875905808947 0.196586449684122 no 688 0.194102849641684 977 711240
SGTC_2848 9016370 25.97 µM 0.862710322550173 0.196632799356173 no 689 0.194148377737691 988 7894410
SGTC_649 1123-0311 367 µM 0.860597788401905 0.197224715713975 no 690 0.194729802214612 981 693629 YIL048W NEO1
SGTC_2332 7982454 138.89 µM 0.858528727001039 0.197805495028914 no 691 0.195300287443309 959 2981748
SGTC_1638 st008370 60.6 µM 0.857879488801829 0.197987947019974 no 692 0.195479505631341 945 24207134
SGTC_124 0136-0217 7.121 µM 0.855854604966621 0.198557641962216 no 693 0.196039103517818 1103 3976905
SGTC_511 blebbistatin 171 µM 0.85467416457254 0.198890211051284 no 694 0.196365778497419 963 3476986 A myosin inhibitor.
SGTC_2920 7982904 15.77 µM 0.853848788432223 0.199122946124828 no 695 0.196594388917869 911 6456808
SGTC_3080 9117754 49.47 µM 0.853118249232911 0.199329076401907 no 696 0.196796866118956 1016 9550191
SGTC_617 3770-0098 35 µM 0.851455798706388 0.199798635127393 no 697 0.197258103512209 929 5962639
SGTC_2657 nystatin 74.44 µM 0.847941506532897 0.200793433406795 no 698 0.198235273703241 998 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_217 ketoconazole 989 nM 0.847099130304383 0.20103232760509 no 699 0.198469934922787 959 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2030 5175110 200 µM 0.84532906355008 0.201534865946722 no 700 0.198963569153837 978 2831986
SGTC_2019 4016004 108 µM 0.843107945335523 0.202166525680093 no 701 0.199584037763397 944 45595336
SGTC_2056 5235370 200 µM 0.842680055160476 0.202288348516347 no 702 0.19970370236933 926 5511916
SGTC_2363 9053361 176 µM 0.84026838487324 0.202975785909732 no 703 0.200378961703761 995 6469797 YMR079W SEC14
SGTC_2448 5185112 27.17 µM 0.838829621015886 0.20338656365284 no 704 0.200782463027633 902 5718189
SGTC_1278 0874-0585 172 µM 0.83847133487455 0.203488934086727 no 705 0.20088302016508 981 766306
SGTC_1436 4092-1007 8.32 µM 0.837894731854457 0.20365374709754 no 706 0.201044913887729 984 2881121
SGTC_447 ml7 120 µM 0.83750231609145 0.203765958548665 no 707 0.201155137810037 1006 4216 Selective myosin light chain kinase inhibitor.
SGTC_579 4491-1009 110 µM 0.836125796361554 0.204159866241409 no 708 0.201542068746611 1178 1271041
SGTC_1720 st037298 9.481 µM 0.834633119278883 0.204587525904063 no 709 0.20196215434914 950 597396
SGTC_1740 st038286 13.222 µM 0.832833526128406 0.205103826665186 no 710 0.202469311891512 972 716786
SGTC_2553 4-methylesculetin 85.09 µM 0.830851903373782 0.205673246328689 no 711 0.20302864859655 1038 5319502
SGTC_678 1218-2179 85.9 µM 0.830109889008562 0.205886705509167 no 712 0.203238328228416 979 6820081 YOR116C RPO31
SGTC_1564 D-Arginine 115 µM 0.828859296204702 0.206246767398187 no 713 0.203592015129922 986 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2568 diosmetin 100 µM 0.827293579116104 0.206698083431165 no 714 0.204035341108615 1008 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_3250 9135583 49.47 µM 0.826421824397575 0.206949618895619 no 715 0.204282423716491 993 7699353
SGTC_1147 3809-1045 12.3 µM 0.825857992136392 0.207112403066264 no 716 0.204442326285584 997 325925
SGTC_1718 roemerine 11.9335 µM 0.8255117878228 0.20721239333389 no 717 0.204540546574186 975 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1091 telmisartan 47.6 µM 0.824375062427269 0.207540901550294 no 718 0.20486323994958 1058 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_32 0928-0142 34.1 µM 0.824362659744797 0.207544487562951 no 719 0.204866762489279 1005 2244242
SGTC_1324 1418-0026 34.4 µM 0.821499397567719 0.208373327947428 no 720 0.205680933550404 1005 1372513
SGTC_1487 3970-0795 2.82 µM 0.820707263032902 0.208602974737358 no 721 0.205906516370201 1034 3765103
SGTC_2137 5261020 140 µM 0.820181498459869 0.20875548087185 no 722 0.206056323775561 987 763655
SGTC_1987 st072290 61.9 µM 0.819192985021541 0.209042392296504 no 723 0.206338158299309 1024 54697379
SGTC_3041 9091929 49.47 µM 0.818234711353951 0.209320748324441 no 724 0.206611589126897 1081 25236887
SGTC_1943 st076331 65.2 µM 0.817999220145942 0.209389186373762 no 725 0.206678816288788 1096 24208415
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.817021917326765 0.209673349111967 no 726 0.206957951485533 1006 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2015 5119600 184 µM 0.815827380388153 0.210020983132992 no 727 0.20729943545403 1022 2828786
SGTC_2263 7948595 193.29 µM 0.813668255435684 0.210650190030515 no 728 0.207917512241987 937 2971371
SGTC_3129 9127257 49.47 µM 0.81360009738109 0.210670070474482 no 729 0.207937041046313 921 837894
SGTC_2036 5160441 105 µM 0.810062868310719 0.21170332486781 no 730 0.208952021934499 1066 134534 YIL048W NEO1
SGTC_1036 k216-0215 33.5 µM 0.809399673564383 0.211897379281196 no 731 0.209142644957663 998 622330
SGTC_2412 st077135 33.4 µM 0.808922395450104 0.212037097836996 no 732 0.209279893031102 1003 13258915
SGTC_470 aa-861 153 µM 0.808482371612603 0.212165958282056 no 733 0.209406475065724 1039 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_996 3970-0799 1.8 µM 0.807836161653395 0.212355283046712 no 734 0.209592452477797 1179 6615648 YGL040C HEM2
SGTC_3171 9103192 49.47 µM 0.805079972772689 0.213163891198253 no 735 0.210386765972714 1097 13018434
SGTC_2603 homopterocarpin 100 µM 0.804812286028475 0.213242520450705 no 736 0.21046400537832 1028 101795 A weak amylase inhibitor.
SGTC_523 1934-0222 13.7 µM 0.804328225015437 0.213384749567737 no 737 0.210603720537685 1005 1361595
SGTC_3316 9136639 10.545 µM 0.802224352178444 0.214003561678586 no 738 0.211211596065366 1022 4903665
SGTC_1250 0485-0349 40.2 µM 0.801158303436067 0.214317516921008 no 739 0.211520003357225 1021 6842794 YDL195W SEC31
SGTC_1905 st060207 84.5 µM 0.800720037920106 0.214446665382251 no 740 0.211646869763525 1015 1948547
SGTC_1426 4048-4480 71.7 µM 0.800444860733197 0.21452777795524 no 741 0.211726549120471 1045 14224343
SGTC_2790 5423970 71.43 µM 0.799359621865146 0.214847842097386 no 742 0.212040958234235 1051 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1990 st072050 59.8 µM 0.798208874727262 0.215187529097984 no 743 0.21237464409197 1078 17233948
SGTC_3290 9121031 71.43 µM 0.790388448777586 0.217504270323504 no 744 0.214650473057661 1012 17014854
SGTC_2186 6124449 200 µM 0.788499975314099 0.218065866606987 no 745 0.215202156506347 1037 3834182 YLR033W RSC58
SGTC_3219 9131112 49.47 µM 0.78833121040224 0.218116094753474 no 746 0.215251498157989 1012 17612988 YMR079W SEC14
SGTC_1069 diphenylcyclopropenone 8.49 µM 0.787341301245689 0.218410847708901 no 747 0.215541049215572 1141 65057 A dermal irritant. YDR527W RBA50
SGTC_901 1112-0062 60.1 µM 0.786101096378112 0.218780451670908 no 748 0.215904131025576 1093 1908457
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.78593825843135 0.218829007104086 no 749 0.21595182969555 1163 688801
SGTC_942 3253-1115 227 µM 0.785712343636189 0.218896381219615 no 750 0.216018015015129 1061 46497897
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.784382025479315 0.219293361287398 no 751 0.216407991056874 1052 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_368 fentichlor 4.58 µM 0.784024340528018 0.219400168547278 no 752 0.2165129140543 1007 7329 A pesticide.
SGTC_1073 triclabendazole 3.09 µM 0.782668734593338 0.219805233285588 no 753 0.216910833408009 1089 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_191 3914-0123 66.505 µM 0.780193277384798 0.220546024179544 no 754 0.217638559367081 966 3144412
SGTC_2357 9067248 200 µM 0.778887045658742 0.22093749534317 no 755 0.218023127792729 1032 9150235
SGTC_538 2922-0838 53.3 µM 0.777118214045061 0.221468238873565 no 756 0.218544514429496 1119 777039
SGTC_3140 9094243 49.47 µM 0.776540282231276 0.221641806997973 no 757 0.21871502299165 1144 19291112
SGTC_3288 9119690 36.221 µM 0.773665392055833 0.222506366357395 no 758 0.219564345411013 1039 17595618 YKL019W RAM2
SGTC_2583 asiatic acid 100 µM 0.772502299468192 0.222856686258898 no 759 0.21990849275397 1100 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_2305 7443522 69.23 µM 0.770697651577966 0.22340086219586 no 760 0.22044308212844 1079 5415886
SGTC_1469 k284-2957 126 µM 0.770440664483251 0.223478415878404 no 761 0.220519269743735 1101 23884841
SGTC_1062 mesoridazine 14.2 µM 0.768448603003282 0.224080100348241 no 762 0.221110357313281 1091 4078 A neuroleptic.
SGTC_2682 pyrogallin 40.03 µM 0.767826473824262 0.22426819732882 no 763 0.221295142052481 1137 822798 An ATP competetive kinase inhibitor.
SGTC_1956 st077085 54 µM 0.767792133154288 0.224278582631955 no 764 0.221305344485966 1126 24208685
SGTC_3065 9113888 49.47 µM 0.766566686506846 0.224649360799209 no 765 0.221669594318128 1065 16648368
SGTC_135 0933-0004 26.348 µM 0.76580885473053 0.224878828612191 no 766 0.221895022367616 1021 21230617 YGL099W LSG1
SGTC_496 calpeptin 138 µM 0.765148458536483 0.225078901701345 no 767 0.222091573501604 1060 73364 A calpain inhibitor.
SGTC_635 k038-0028 24.7 µM 0.764115038512983 0.22539218809629 no 768 0.222399345604947 1088 4035102
SGTC_654 1124-0271 80.9 µM 0.762588000796072 0.22585556876295 no 769 0.222854571450608 1079 5403748
SGTC_2598 perillyl alcohol 100 µM 0.761908692721341 0.226061878287941 no 770 0.223057250751369 1090 10819 An apoptosis inducer.
SGTC_121 0557-0495 61.343 µM 0.761299943698066 0.226246849112316 no 771 0.223238967102574 1242 3104427
SGTC_1900 st060200 72.8 µM 0.760940190041605 0.226356201884403 no 772 0.223346395987818 1104 688945
SGTC_2184 6075246 200 µM 0.759662406311726 0.22674484553401 no 773 0.223728202818267 1062 2267320
SGTC_1737 st035557 69.7 µM 0.759121431045217 0.226909498966814 no 774 0.223889960104441 964 5716916
SGTC_714 4296-0578 26.1 µM 0.758990569004965 0.226949338797098 no 775 0.223929099209685 1118 1589775
SGTC_2180 6301957 200 µM 0.758937374326777 0.226965534590119 no 776 0.223945010145643 1093 845462
SGTC_2972 9093619 59.92 µM 0.757027021620557 0.227547597498093 no 777 0.224516836896745 1083 25236256
SGTC_3326 9140064 16.379 µM 0.75555970735254 0.227995241785534 no 778 0.224956610731118 1122 1868434
SGTC_192 3455-0609 60.9 µM 0.755343574906075 0.228061220720598 no 779 0.22502142976369 1132 3769639
SGTC_2763 lisinopril 49.32 µM 0.754765117929597 0.228237859590404 no 780 0.225194963512971 1061 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1736 st036774 51 µM 0.754342866206264 0.228366847832266 no 781 0.225321684439177 1140 1272247
SGTC_1020 4335-0961 93.3 µM 0.753717559647316 0.228557939911806 no 782 0.225509417807502 1013 669075
SGTC_1519 esterone 74 µM 0.750759473982479 0.229463139696653 no 783 0.226398711477716 1110 698 A steroid.
SGTC_1640 st009078 66.4 µM 0.750683239320897 0.229486494687432 no 784 0.226421656165136 1070 690618
SGTC_1385 3091-4834 14.1 µM 0.749345865736772 0.229896424485501 no 785 0.226824385003351 1058 4072814
SGTC_2423 st077119 87.2 µM 0.746646988671974 0.230724927294561 no 786 0.227638338365012 1116 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1767 st044992 70.3 µM 0.746486747854909 0.230774170509364 no 787 0.227686716996221 1124 9600693
SGTC_1327 1436-0082 2.18 µM 0.744916207693925 0.231257119975355 no 788 0.228161188217195 1067 15992205
SGTC_112 phenothiazine 287.218 µM 0.744470873504821 0.231394165142704 no 789 0.228295827902891 1129 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1376 2910-0861 41.3 µM 0.742235002152419 0.232082906334725 no 790 0.228972482452635 1131 1112859
SGTC_2856 9022925 19.48 µM 0.741546682677096 0.232295166817859 no 791 0.229181018836864 1100 4944862
SGTC_3291 9121177 71.43 µM 0.741420683095877 0.232334033624308 no 792 0.229219203770249 1050 17015612
SGTC_3185 9108267 49.47 µM 0.741166036942303 0.232412594791515 no 793 0.229296386713574 1127 4910486
SGTC_3260 9137109 49.47 µM 0.740267392664171 0.232689954575359 no 794 0.229568881122396 990 17478346
SGTC_1049 3226-0134 66 µM 0.73935101658606 0.2329729764971 no 795 0.229846939050754 1172 5702385
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.739123820445089 0.233043175385057 no 796 0.229915906813365 1159 165521
SGTC_322 k048-0136 19.3 µM 0.735437649596655 0.23418376541049 no 797 0.231036499775942 1147 6823282
SGTC_1475 4092-1048 11.7 µM 0.734415924219416 0.234500458055474 no 798 0.231347642205213 1159 2881759
SGTC_3221 9128209 49.47 µM 0.734388913428325 0.234508833497802 no 799 0.231355870875779 1120 16460723
SGTC_1234 0326-0494 15.5 µM 0.733858312894685 0.234673394408605 no 800 0.231517548142767 1140 1547813
SGTC_2634 4'-methoxyflavone 100 µM 0.732994814152943 0.234941337121523 no 801 0.231780796163085 1100 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1567 st069303 68.4 µM 0.732543596285207 0.235081416751152 no 802 0.231918421687938 1157 5581319
SGTC_43 0570-0105 72.5 µM 0.731791928995186 0.235314872673397 no 803 0.232147788020779 1173 1114046 YDL195W SEC31
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.729758019322174 0.235947213942303 no 804 0.232769054760407 1085 688803
SGTC_1926 methyl fluorone black 53.6 µM 0.728496142169209 0.236340001043106 no 805 0.233154964682976 1023 72721 Reacts with homocysteine.
SGTC_3162 9099653 49.47 µM 0.728194188057013 0.236434044273205 no 806 0.233247361560468 1123 25237511
SGTC_2037 5169046 200 µM 0.726342222375888 0.237011287006491 no 807 0.233814500752753 1131 5718022
SGTC_1125 tnp00248 1.32998 µM 0.725751250713385 0.237195650983649 no 808 0.233995638467326 1241 24207736
SGTC_1185 1319-0113 81.3 µM 0.722741467517565 0.238135826863383 no 809 0.234919366988452 1144 4672763
SGTC_89 0302-0250 142.109 µM 0.72136174320463 0.238567497549991 no 810 0.235343488990019 1235 4203518 YLR208W SEC13
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.719705101321681 0.239086372071531 no 811 0.235853292346497 1133 17037758
SGTC_285 1486-1325 46 µM 0.718885542385762 0.239343292884862 no 812 0.2361057225745 1152 22310230
SGTC_541 4513-1321 94 µM 0.718190239014696 0.239561379422463 no 813 0.236319997815674 1136 747515
SGTC_2177 5811945 192 µM 0.717869820763398 0.239661917246491 no 814 0.236418778796107 1173 5343475
SGTC_2694 st077685 81.9 µM 0.716205334058475 0.240184554549901 no 815 0.236932284961833 1156 2838096
SGTC_2323 6148992 148.28 µM 0.715845074171286 0.240297755376906 no 816 0.237043508395892 1123 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_26 0302-0163 425.158 µM 0.714731904423099 0.240647719073451 no 817 0.237387359760324 1193 3100915
SGTC_2506 ethyl hematommate 54.16 µM 0.714488288215409 0.240724345302331 no 818 0.237462647834016 1137 3940691 An allergen.
SGTC_2284 7945075 39.21 µM 0.71439581280553 0.240753435685658 no 819 0.237491230216041 1242 1245402
SGTC_959 1222-0044 107 µM 0.713983555736614 0.2408831444177 no 820 0.237618673969665 1157 6083612
SGTC_304 1310-0298 97 µM 0.71345838940479 0.241048432914732 no 821 0.237781076447099 1128 1550234
SGTC_13 0199-0087 65 µM 0.712627057127036 0.241310208742505 no 822 0.23803828212241 1181 4589825
SGTC_841 0251-0215 91.2 µM 0.711373102090058 0.241705355088986 no 823 0.238426531260749 1201 3888614
SGTC_233 rapamycin 362 pM 0.709263646521351 0.242370878416192 no 824 0.2390804417316 1198 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_51 1013-0126 23.419 µM 0.709257047623428 0.242372961894223 no 825 0.239082488861986 1224 1627850
SGTC_1355 1499-0035 1.68 µM 0.707964544765723 0.242781232421221 no 826 0.239483637737592 1184 1548538
SGTC_1631 benzylvanillin 81.9 µM 0.707213183235903 0.243018740407662 no 827 0.239717003586387 1167 75506
SGTC_1829 berberine 14.4 µM 0.705952871032339 0.243417411505122 no 828 0.240108723232877 1175 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_744 1594-0068 283 µM 0.704067501090195 0.244014464512516 no 829 0.240695368925482 1215 668392
SGTC_2894 9048625 32.47 µM 0.703650307098496 0.244146686852076 no 830 0.240825287006554 1233 4092861
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.700245784690808 0.245227133296752 no 831 0.241886911589154 1207 115019
SGTC_2915 7971052 15.16 µM 0.700092587809474 0.245275811652957 no 832 0.241934742252283 1076 5741558
SGTC_3136 9095672 49.47 µM 0.699522742123758 0.245456925883784 no 833 0.242112702762556 1045 17217380
SGTC_105 0111-0055 734.78 µM 0.699485285488809 0.245468833254108 no 834 0.242124402804147 1125 5179370
SGTC_923 1900-2434 73.3 µM 0.699166816979198 0.245570086131154 no 835 0.242223892750847 1185 5910570
SGTC_661 1304-0007 33.6 µM 0.69825450959847 0.245860266416939 no 836 0.242509021299679 1191 3117130
SGTC_2701 st077767 14.721 µM 0.698186100619359 0.245882032876792 no 837 0.242530408866404 1204 5721188
SGTC_314 1671-0008 2.74 µM 0.697741786391234 0.246023430537685 no 838 0.242669345320313 1143 3913060
SGTC_2260 7964312 200 µM 0.697097685001419 0.246228485492719 no 839 0.242870831434213 1212 231951
SGTC_2949 9072542 2.23 µM 0.695776726276081 0.246649310053549 no 840 0.243284333329375 1221 16457352
SGTC_3305 9127027 53.8275 µM 0.694828495995569 0.246951629943728 no 841 0.243581393873888 1133 41905295
SGTC_943 3253-1379 105 µM 0.694537527811612 0.247044437732436 no 842 0.243672587330713 1189 668464
SGTC_59 0330-0160 1.33 µM 0.694327116662271 0.247111562513589 no 843 0.243738544581142 1204 4293482
SGTC_2766 oltipraz 83.91 µM 0.694274381362973 0.247128387511281 no 844 0.243755076942407 1175 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_771 0250-0039 27.3 µM 0.694098121067084 0.247184627137874 no 845 0.243810338419379 1172 3005115
SGTC_762 1165-0429 115 µM 0.693503226031371 0.24737449167738 no 846 0.243996901002897 1192 5967793
SGTC_2414 st077232 92.9 µM 0.693252875671734 0.247454415887382 no 847 0.244075435366354 1157 729801
SGTC_1774 st048371 48.465 µM 0.692522930863776 0.247687529103912 no 848 0.244304495270099 1182 4242727
SGTC_3181 9108277 49.47 µM 0.689961181851965 0.248506569572992 no 849 0.245109299492379 1178 17097298
SGTC_35 0133-0054 64.071 µM 0.689796116879962 0.248559393466192 no 850 0.245161205490637 1158 99677
SGTC_430 0958-0115 16.4 µM 0.687174799305499 0.24939906556392 no 851 0.245986291442154 1163 6833180
SGTC_2192 5915882 198.485 µM 0.686831537833557 0.24950913213888 no 852 0.246094446644361 1168 2876149
SGTC_813 k007-0158 173 µM 0.685087014470413 0.250068911143421 no 853 0.246644506988257 1233 6523916
SGTC_963 1269-2853 151 µM 0.684990463605493 0.250099911629192 no 854 0.246674969365729 1204 3668223
SGTC_1506 4226-2149 212 µM 0.684750780791666 0.250176877634738 no 855 0.246750599440699 1231 991114
SGTC_1470 k295-0292 231 µM 0.683506134357463 0.250576755526564 no 856 0.2471435376374 1244 5045612
SGTC_423 5-fluorouracil 457 µM 0.68344519386988 0.25059634307461 no 857 0.247162785302302 1192 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3293 9120939 62.045 µM 0.683298714004881 0.250643428086496 no 858 0.247209053314049 1218 934087
SGTC_3036 9090181 49.47 µM 0.682406949697087 0.250930181070378 no 859 0.247490831256566 1227 25236586
SGTC_2237 6667747 47.222 µM 0.682238676139764 0.250984310063459 no 860 0.247544021246962 1153 729940 YDL015C TSC13
SGTC_3323 9138564 53.9225 µM 0.682223988978404 0.25098903481404 no 861 0.247548664036627 1229 43912313 YNL103W MET4
SGTC_1272 0839-0021 27 µM 0.680723799678197 0.251471882377089 no 862 0.248023137011519 1215 5027250
SGTC_2739 tacrine 100.86 µM 0.680019516200382 0.251698730678288 no 863 0.248246051803943 1226 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1021 4476-0760 85.3 µM 0.678979749979931 0.252033834749225 no 864 0.248575346389084 1202 746768
SGTC_648 0375-0473 33.3 µM 0.677097002055875 0.252641220129376 no 865 0.249172205456587 1224 1713139
SGTC_712 r015-0009 80.6 µM 0.676100291245421 0.252963076641232 no 866 0.249488485883877 1190 6813872 YLR060W FRS1
SGTC_482 fipronil 114 µM 0.674901214603598 0.253350566602023 no 867 0.249869264396756 1252 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2969 9091408 28.7 µM 0.674406946038983 0.253510383694118 no 868 0.250026313956034 1185 4286311
SGTC_3024 9090631 49.47 µM 0.67386575155273 0.253685434575029 no 869 0.250198333871895 1188 25236383
SGTC_2840 9008771 71.43 µM 0.673650850105299 0.253754962657082 no 870 0.250266658198826 1203 2992978
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.673414209561322 0.253831535664988 no 871 0.250341905551971 1197 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1089 terbinafine 2.25 µM 0.672882451069567 0.254003648254513 no 872 0.25051103874796 1217 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3322 9139058 2.11 µM 0.672782832854515 0.254035898175806 no 873 0.250542730441543 1271 4908926 YPR165W RHO1
SGTC_557 1315-0110 16.2 µM 0.670727515034948 0.254701755955177 no 874 0.251197065560839 1238 6833801
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.670061955488271 0.254917571860357 no 875 0.251409147990134 1251 2724 A muscle relaxant with antifungal properties.
SGTC_3051 9093778 49.47 µM 0.669945846227867 0.254955231523684 no 876 0.25144615622681 1249 17217378
SGTC_3292 9120825 59.784 µM 0.667095109041561 0.255880771320444 no 877 0.252355692033371 1251 24824900
SGTC_421 streptovitacin 30 mM 0.666479609540174 0.256080833506232 no 878 0.252552296298574 1272 91467 include heat shock
SGTC_865 0488-0499 301 µM 0.666387393436004 0.25611081448869 no 879 0.25258175912777 1259 9634651
SGTC_517 1365-0151 113 µM 0.664768397047938 0.256637475070285 no 880 0.25309931949053 1278 768657
SGTC_1381 2324-0066 62.1 µM 0.664082524397576 0.25686075984004 no 881 0.253318747198375 1249 10885928
SGTC_1394 3474-0001 65.7 µM 0.662849446686439 0.257262440476883 no 882 0.253713490783128 1187 5017666 YIL048W NEO1
SGTC_3206 9114350 49.47 µM 0.66190597370443 0.257570001410306 no 883 0.254015741559754 1202 17087243
SGTC_2020 4017018 200 µM 0.66109582346455 0.257834253028701 no 884 0.254275431775775 1262 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_302 1094-0063 18.9 µM 0.65877215200136 0.258592958768708 no 885 0.255021046228153 1205 5440289
SGTC_2038 4100038 30.985 µM 0.658728709334789 0.258607154304765 no 886 0.255034996897105 1247 3596803
SGTC_604 1000-0114 314 µM 0.658131077943503 0.258802480179404 no 887 0.255226953756727 1295 1572745
SGTC_442 cape 100 µM 0.656559404585265 0.25931651961167 no 888 0.255732129406058 1245 5281787
SGTC_1610 st001799 48.1 µM 0.656108728480231 0.259464017285221 no 889 0.255877084379958 1198 621897
SGTC_2922 7999257 32.47 µM 0.655832152540876 0.259554556753876 no 890 0.255966063192838 1248 2988377
SGTC_3002 9075603 71.4286 µM 0.654245221684511 0.260074367126859 no 891 0.256476915599893 1244 20105405
SGTC_3321 9137793 26.8275 µM 0.651059006834691 0.261119652491635 no 892 0.257504198625365 1261 4904192
SGTC_2493 resveratrol 26.09 µM 0.65061469414342 0.261265587272837 no 893 0.2576476212564 1202 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2871 9038510 12.99 µM 0.647309940536936 0.262352349055077 no 894 0.258715684630158 1285 4945164
SGTC_2073 5212005 126 µM 0.645142655105248 0.263066311496227 no 895 0.259417371920281 1173 691789
SGTC_486 niguldipine 82 µM 0.64401625704089 0.263437769222881 no 896 0.259782446027069 1273 1236 A calcium channel blocker.
SGTC_1663 st014140 55.4 µM 0.643592888088842 0.263577454843809 no 897 0.25991973161294 1345 4207120
SGTC_1257 0669-0121 16 µM 0.64291748038487 0.263800375907685 no 898 0.260138823091747 1310 4307855
SGTC_2163 5671233 125 µM 0.642656346618652 0.263886589934198 no 899 0.260223556228265 1346 701023
SGTC_1827 berberine 7.24 µM 0.642626710247444 0.26389637537065 no 900 0.260233173587929 1197 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1002 4049-0206 172 µM 0.641173809365891 0.264376325769377 no 901 0.26070488193608 1292 4662749
SGTC_1206 3978-0017 132 µM 0.640397754609604 0.264632869161434 no 902 0.260957021137786 1354 3873677
SGTC_3265 9137266 49.47 µM 0.63900028855854 0.265095153955307 no 903 0.261411372085374 1238 17224265
SGTC_2461 5755302 26.15 µM 0.638830317925524 0.265151408575376 no 904 0.26146666146052 1334 2788904
SGTC_2436 5633522 8.09 µM 0.638117441509126 0.265387412950025 no 905 0.261698616853854 1272 5724242
SGTC_459 nigericin 15.3 µM 0.637109644593613 0.265721235288121 no 906 0.262026713389858 1336 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_208 k072-0098 12.366 µM 0.636564803550486 0.26590179688175 no 907 0.262204178623441 1285 5948901
SGTC_1112 tnp00069 1.16933 µM 0.63640311581608 0.26595539253441 no 908 0.262256855282766 1347 145826
SGTC_578 3460-0051 92 µM 0.635592010290655 0.266224337363405 no 909 0.262521189205752 1345 2876744
SGTC_48 0382-0018 55 µM 0.635473775214675 0.266263553019324 no 910 0.262559732620032 1384 762596
SGTC_783 0848-0141 92.7 µM 0.632864668496828 0.267129672802454 no 911 0.263411010989962 1282 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1223 0764-0573 147 µM 0.632318130836089 0.267311281599078 no 912 0.263589509229335 1305 1609797
SGTC_766 1391-0721 126 µM 0.631770267739106 0.267493393325764 no 913 0.26376850227554 1315 1020919 YIL115C NUP159
SGTC_936 3005-4620 401 µM 0.631259259306207 0.267663310799447 no 914 0.263935510340561 1354 777207
SGTC_1151 3909-8316 15.3 µM 0.629480229575528 0.26825528720058 no 915 0.264517353996662 1297 800431
SGTC_1923 st058458 19.1 µM 0.628259005588258 0.268662033328637 no 916 0.264917140968291 1382 3534982
SGTC_2525 harmine 47.85 µM 0.627790665486118 0.268818102872732 no 917 0.265070540925533 1278 5280953 A monoamine oxidase inhibitor
SGTC_653 0203-0016 55.2 µM 0.62651632809304 0.269242993140711 no 918 0.265488165258003 1327 295302
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.623893424859556 0.270118581818172 no 919 0.266348789347089 1315 551469
SGTC_638 3970-0837 4.09 µM 0.622914114359936 0.270445864206811 no 920 0.266670481185781 1289 4118451 YLR208W SEC13
SGTC_2594 a-mangostin 100 µM 0.621492355340124 0.270921363867337 no 921 0.267137861410819 1337 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_200 k038-0079 37.545 µM 0.621005118089697 0.271084413671674 no 922 0.26729812784372 1310 3436683
SGTC_1335 1486-0900 202 µM 0.620616687350399 0.271214433767509 no 923 0.267425928701159 1306 X1335
SGTC_2906 7926292 26.41 µM 0.62019054617841 0.271357112496302 no 924 0.267566172428606 1293 2966319
SGTC_1553 gossypol 38.6 µM 0.618867870861686 0.271800202956111 no 925 0.26800170296914 1244 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2214 7179297 48.276 µM 0.617109589932223 0.272389776278839 no 926 0.268581221835087 1352 769744
SGTC_2438 5259590 200 µM 0.616643036351675 0.272546324033114 no 927 0.268735100767257 1319 1201127
SGTC_329 k048-0121 21.3 µM 0.616016293346937 0.272756692153976 no 928 0.268941883140776 1323 6832902
SGTC_1760 st045453 10.4495 µM 0.615162047384175 0.273043551980596 no 929 0.269223854527282 1326 3323419 YIL048W NEO1
SGTC_1054 3429-0080 167 µM 0.614061838276568 0.273413227593221 no 930 0.269587232323442 1344 1162877
SGTC_672 1441-0018 53.7 µM 0.613224945062254 0.273694593632646 no 931 0.269863806436052 1282 251141
SGTC_1635 st007035 42.4 µM 0.613113439758431 0.273732092865096 no 932 0.269900667115854 1354 3716403
SGTC_1888 azatryptophan 97.5 µM 0.612075675527706 0.274081214802573 no 933 0.270243845126025 1294 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1899 st063254 59.6 µM 0.609866634876002 0.274825106312631 no 934 0.270975078066593 1264 3093813
SGTC_176 1486-1328 72.834 µM 0.607233213253736 0.275713205943991 no 935 0.271848076757652 1306 22310231
SGTC_484 loperamide 105 µM 0.606991245343816 0.275794878326331 no 936 0.271928361046771 1308 3955 An opioid-receptor agonist.
SGTC_1556 plumbagin 1.48 µM 0.606529430280375 0.275950789576082 no 937 0.272081622747542 1276 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2992 9074591 71.4286 µM 0.603612530654949 0.276936549632894 no 938 0.273050639941194 1347 17741321
SGTC_2121 5257820 149.641 µM 0.60286978347357 0.277187834600773 no 939 0.27329765942736 1363 791256
SGTC_2074 5212007 75.395 µM 0.601752446697119 0.277566060079809 no 940 0.27366946659319 1277 758611
SGTC_2231 micatex 6.853 µM 0.600492831025374 0.277992750019868 no 941 0.274088918611923 1350 20737 An antifungal of unknown mechanism.
SGTC_593 1203-0218 61.7 µM 0.599577645173809 0.278302966313817 no 942 0.274393874599173 1381 3666956
SGTC_392 N-ethylmaleimide 8.33 µM 0.599071259072739 0.278474686145165 no 943 0.274562683276094 1292 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2716 st080858 38.6235 µM 0.598865693461627 0.278544409919656 no 944 0.274631225167132 1314 5296050
SGTC_2773 thioridazine 9.09 µM 0.598223485032465 0.278762289033216 no 945 0.274845411542756 1364 5452 An antipsychotic.
SGTC_1308 1187-1617 41.4 µM 0.59801313066849 0.278833673026976 no 946 0.274915585851139 1335 2882570
SGTC_1626 st003712 1.76 µM 0.597916081123044 0.278866609899634 no 947 0.274947964598356 1330 24207035
SGTC_2300 7976697 71.57 µM 0.597274795013102 0.279084298459875 no 948 0.275161964810999 1289 2236109
SGTC_278 4092-0821 23.9 µM 0.59719716436455 0.27911065627223 no 949 0.275187876090184 1357 877900
SGTC_1123 mangostin 811.285 nM 0.595949648409036 0.279534389329653 no 950 0.275604432182497 1345 5281650 An antioxidant.
SGTC_385 1494-0393 12.4 µM 0.595620376779957 0.279646282280348 no 951 0.27571443044868 1371 3090647
SGTC_1643 st009866 20.2 µM 0.595206668290166 0.27978689933864 no 952 0.275852666732921 1337 3156273 YOR207C RET1
SGTC_2331 7980721 200 µM 0.594210370804538 0.280125675642809 no 953 0.276185708604246 1357 2981221
SGTC_24 0417-1663 219 µM 0.59353517422403 0.28035537925983 no 954 0.27641152514395 1332 4329390
SGTC_911 3456-4043 236 µM 0.593008708167531 0.280534547631888 no 955 0.276587662217803 1438 914281
SGTC_1685 st024049 53.0905 µM 0.591768536198085 0.280956825243119 no 956 0.277002797571016 1330 1941139
SGTC_1637 st007924 17.4 µM 0.59154959213243 0.281031407422587 no 957 0.277076118605395 1323 683336
SGTC_3128 9127691 49.47 µM 0.590854176927604 0.281268360490367 no 958 0.277309065545731 1361 41316314
SGTC_268 camptothecin 39.6153 µM 0.590649610056828 0.281338082164968 no 959 0.277377608627898 1369 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2533 agelasine 13.65 µM 0.589925137043184 0.281585068349402 no 960 0.27762042035894 1421 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_729 4092-0585 94.1 µM 0.589851940229241 0.281610028305916 no 961 0.277644958510609 1319 2169061
SGTC_205 1486-1330 71.903 µM 0.588048618294659 0.282225293925725 no 962 0.278249829941662 1366 4118834
SGTC_2665 lovastatin 100 µM 0.587259853442871 0.282494611546986 no 963 0.278514599787558 1331 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_3087 9117406 49.47 µM 0.585444532754711 0.283114907741782 no 964 0.279124426200853 1332 42546093
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.584422877734491 0.283464295081414 no 965 0.279467919250866 1384 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2465 5809242 33.21 µM 0.584217246834771 0.283534642066008 no 966 0.27953707971078 1374 2731748
SGTC_2929 9013348 24.6 µM 0.582236831318536 0.28421257642344 no 967 0.280203583901843 1373 2995952
SGTC_85 0868-0259 160.055 µM 0.582069951295892 0.28426973805378 no 968 0.280259782134413 1376 83173
SGTC_665 3914-0008 307 µM 0.581745005488892 0.284381057928266 no 969 0.280369225994872 1309 1069549
SGTC_2549 cedrol 20.94 µM 0.579015392781074 0.285316989625106 no 970 0.281289393464785 1408 6708665 A sedative which affects the nervous system.
SGTC_730 1436-0052 41.2 µM 0.579006595309326 0.285320008479628 no 971 0.281292361496408 1371 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1114 scopoletin 1.73284 µM 0.578864492089908 0.285368773340844 no 972 0.281340305415481 1402 5280460 A coumarin with genotoxic properties.
SGTC_1624 st003710 6.25 µM 0.578750497200993 0.285407895274034 no 973 0.28137876877248 1412 24207033
SGTC_1224 0823-0416 294 µM 0.578676749323395 0.285433206186352 no 974 0.281403653616749 1426 3598164
SGTC_2106 5357045 167.29 µM 0.577390375096699 0.285874872825146 no 975 0.281837887323668 1434 668842
SGTC_1107 amlodipine 47 µM 0.577383592958012 0.285877202280844 no 976 0.281840177585378 1292 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_603 3794-0023 45.9 µM 0.576793295522689 0.286079985832728 no 977 0.282039549591759 1399 3802260
SGTC_2062 5245942 200 µM 0.576604653221341 0.286144804106028 no 978 0.282103277542194 1424 1376160
SGTC_2607 solasodine 47.35 µM 0.574755146851568 0.286780671332572 no 979 0.282728452631359 1376 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_3247 9135149 49.47 µM 0.573925900169287 0.287065986764314 no 980 0.283008972794735 1349 8934436 YOR116C RPO31
SGTC_3096 9117468 49.47 µM 0.572689209599071 0.287491739253301 no 981 0.283427572390168 1302 41316311
SGTC_97 0535-0701 19.132 µM 0.57253512198668 0.28754480753741 no 982 0.283479749321682 1322 2832013 YGL099W LSG1
SGTC_646 4092-0839 27.3 µM 0.570376067696926 0.288288879625135 no 983 0.284211329017887 1457 877796
SGTC_2249 haloperidol 116.36 µM 0.568212162842008 0.289035533175598 no 984 0.284945456806108 1389 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3194 9111903 49.47 µM 0.568145155200775 0.289058668618599 no 985 0.284968204292102 1444 17087251
SGTC_537 1334-0398 209 µM 0.567778336562829 0.289185333960564 no 986 0.285092745760753 1405 5846986
SGTC_1950 st077106 7.18 µM 0.566350188299548 0.289678733121507 no 987 0.285577874566051 1359 13831864
SGTC_2394 5221648 200 µM 0.565641831649133 0.289923603914705 no 988 0.285818642471448 1521 788586
SGTC_1301 naphtanilide LB 4.81 µM 0.56474260650072 0.29023459551831 no 989 0.286124424880628 1475 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2384 9036245 200 µM 0.56446077979474 0.290332095741075 no 990 0.28622029230998 1459 6462766
SGTC_2217 6934799 96.0675 µM 0.564025777537342 0.290482618382949 no 991 0.286368294555067 1388 675606
SGTC_849 0386-0493 241 µM 0.563691948017163 0.290598157264256 no 992 0.286481899098342 1357 726119
SGTC_1837 st055472 66.5 µM 0.563429510200584 0.290689002465868 no 993 0.286571223551494 1443 676091
SGTC_3064 1327-0027 10 µM 0.562444092040306 0.291030232309963 no 994 0.286906742555089 1310 16000455 YPR107C YTH1
SGTC_1311 1190-0148 100 µM 0.561715941403039 0.291282495913478 no 995 0.28715478563123 1454 1961333
SGTC_1915 st067105 30.6 µM 0.559430621403775 0.29207489396954 no 996 0.287933933972209 1355 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_337 1315-0038 354 µM 0.558624900209655 0.292354503911423 no 997 0.288208871307268 1381 1626437
SGTC_2463 5473429 200 µM 0.558599879902709 0.292363188716875 no 998 0.288217411002658 1401 5399405
SGTC_2132 5317594 122.667 µM 0.55575202967634 0.293352489734837 no 999 0.289190191432414 1441 794577
SGTC_1084 voriconazole 435 nM 0.554993013835242 0.293616422183108 no 1000 0.289449719479864 1422 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1925 st057770 10.1 µM 0.55371887850939 0.29405972403319 no 1001 0.28988562660902 1315 5989122
SGTC_2358 9037157 4 µM 0.55351293823463 0.294131404564516 no 1002 0.289956111782114 1446 2388925
SGTC_1856 st057054 55.7 µM 0.553010511247908 0.294306315512572 no 1003 0.290128106285765 1527 1266018
SGTC_1387 3342-1166 1.8 µM 0.55286418223504 0.294357266366167 no 1004 0.290178207698731 1404 3418228
SGTC_1452 4194-0072 190 µM 0.552015493143114 0.294652854920484 no 1005 0.290468869231623 1509 1343545
SGTC_1776 st049249 45.9 µM 0.551800709555503 0.294727683253546 no 1006 0.290542450548096 1377 1822314
SGTC_1933 st074711 15.9 µM 0.551653861420219 0.294778848635936 no 1007 0.29059276331836 1369 17250958
SGTC_2862 9027634 71.43 µM 0.551609511970818 0.29479430184388 no 1008 0.290607959026088 1342 5012562
SGTC_75 0159-0059 199.013 µM 0.550863819950446 0.295054188129189 no 1009 0.290863515442553 1516 5377270
SGTC_2032 5185112 25.99 µM 0.550359401905935 0.295230046166837 no 1010 0.291036444297015 1364 5718189
SGTC_1459 k035-0031 35.7 µM 0.549464114083861 0.295542294041539 no 1011 0.291343492647367 1314 3877128 YMR208W ERG12
SGTC_305 1682-2595 20.8 µM 0.549144214133515 0.295653901765848 no 1012 0.291453242336912 1428 226033
SGTC_168 3970-0862 530.542 µM 0.548493597411151 0.295880950765674 no 1013 0.291676512174838 1422 3135186
SGTC_2588 indole-3-carbinol 100 µM 0.547822350259434 0.296115283161251 no 1014 0.291906945203954 1478 3712 Induces cell cycle arrest.
SGTC_2402 5553605 200 µM 0.547708656220085 0.296154982185107 no 1015 0.291945983726577 1481 6758546
SGTC_2126 5251174 33.877 µM 0.547616269445264 0.296187243060394 no 1016 0.29197770787652 1529 790722
SGTC_84 0443-0269 128.823 µM 0.545001303336758 0.297101040439059 no 1017 0.292876310609372 1373 6150058
SGTC_1919 st067113 52.3 µM 0.542493318591093 0.297978662396868 no 1018 0.293739354486693 1414 1268243
SGTC_357 1325-0123 420 µM 0.542379596970465 0.298018485123969 no 1019 0.293778516073924 1431 1098503
SGTC_647 0140-0236 81 µM 0.541884306014068 0.298191953039578 no 1020 0.293949104418707 1459 990837
SGTC_1019 4262-0212 3.4 µM 0.540713355319374 0.29860224298339 no 1021 0.294352585851705 1459 4677213
SGTC_662 k832-1615 104 µM 0.540540050088062 0.298662989286333 no 1022 0.294412324383313 1460 5878478
SGTC_1273 0849-0096 14.1 µM 0.538498115151286 0.299379143407363 no 1023 0.295116603013306 1420 5286025
SGTC_874 0599-0792 117 µM 0.537996802277557 0.29955508449872 no 1024 0.29528962811848 1487 765305
SGTC_2350 9023895 38.85 µM 0.537753373119362 0.299640535452607 no 1025 0.295373663055461 1494 2997209
SGTC_515 4092-1064 102 µM 0.537097425522491 0.299870847736225 no 1026 0.295600159518043 1539 717353
SGTC_1594 piperine 70.1 µM 0.534818224653521 0.300671728964149 no 1027 0.296387779787241 1399 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2735 sertaconazole 140 nM 0.534492169235747 0.300786379443695 no 1028 0.296500532916721 1493 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_806 3966-4455 5.86 µM 0.533625667246269 0.301091162324054 no 1029 0.296800273202459 1367 714982
SGTC_935 2996-0153 430 µM 0.531296256989412 0.301911196796862 no 1030 0.297606749390921 1454 23738523
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.530629151149136 0.302146226259919 no 1031 0.297837895373774 1472 688664
SGTC_2596 sinensetin 100 µM 0.530506346119523 0.302189500908416 no 1032 0.297880455098241 1425 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_737 1950-0117 57.9 µM 0.529234237917854 0.302637936296125 no 1033 0.298321484242318 1439 5393513
SGTC_1659 st012954 42.1 µM 0.528831234306626 0.302780062702985 no 1034 0.298461264159667 1455 24207262
SGTC_2104 5389443 200 µM 0.528611455753556 0.302857584121013 no 1035 0.298537505877992 1520 2244536
SGTC_2390 9097792 176.6 µM 0.527850383567587 0.303126102044472 no 1036 0.298801592115555 1388 4497149
SGTC_358 0075-0058 9.45 µM 0.527362563481341 0.303298268421491 no 1037 0.298970917772747 1567 1069125
SGTC_845 0330-0138 4.51 µM 0.524893153332827 0.304170467317408 no 1038 0.299828734623621 1502 9039800
SGTC_1192 1488-0095 21.4 µM 0.524511834621606 0.304305249128342 no 1039 0.299961295322682 1459 915875
SGTC_939 1165-0479 45.3 µM 0.524199932649185 0.304415514504406 no 1040 0.300069743872468 1405 1377347
SGTC_1440 4100-1550 40 µM 0.521187234126464 0.305481495127656 no 1041 0.30111817312818 1465 742806
SGTC_1010 4112-3296 15.2 µM 0.521171771742453 0.305486970436638 no 1042 0.301123558345498 1528 704384
SGTC_1534 6-azauridine 81.6 µM 0.520201726536096 0.305830555326672 no 1043 0.301461491047027 1447 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_2130 NSC 7 2.4545 µM 0.5194079032117 0.306111850581149 no 1044 0.301738160600964 1519 21448
SGTC_1193 1488-0126 41.5 µM 0.519321164914729 0.306142593662867 no 1045 0.301768398232058 1461 1384710
SGTC_1141 3253-0389 52.6 µM 0.516860832330521 0.307015189396179 no 1046 0.302626655548785 1448 5402031
SGTC_2420 aureobasidin a 50 nM 0.516586130691033 0.307112684658866 no 1047 0.302722549743731 1603 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1865 st057639 52.2 µM 0.514626387758365 0.307808618849916 no 1048 0.303407060958759 1452 688818
SGTC_2824 7998404 51.95 µM 0.514229600100864 0.307949608429975 no 1049 0.303545737565374 1482 837851
SGTC_62 0180-0423 3.232 µM 0.514146483846637 0.307979145516049 no 1050 0.303574790139119 1413 30102 YGL099W LSG1
SGTC_1819 st053448 58.6 µM 0.510440696303423 0.309297335924249 no 1051 0.304871375913188 1482 2857616
SGTC_793 0488-0545 106 µM 0.510319425680963 0.309340514880194 no 1052 0.304913847791091 1429 292548
SGTC_1391 3442-0225 151 µM 0.510195947405885 0.30938448258614 no 1053 0.304957095542578 1464 5227075
SGTC_2612 dictamnine 15.46 µM 0.509913178211428 0.309485180317559 no 1054 0.305056144538242 1477 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_495 decylubiquinone 155 µM 0.509297936597927 0.309704325152844 no 1055 0.305271702017956 1413 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1621 st003705 32.4 µM 0.506100941362189 0.310844160734723 no 1056 0.306392894876012 1562 24207032
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.506084854359589 0.31084990089303 no 1057 0.306398541219188 1448 2374 Ca(2+)-ATPase inhibitor.
SGTC_2067 5224629 34.075 µM 0.505811238558249 0.310947539430547 no 1058 0.306494584092534 1442 2835000
SGTC_93 0109-0045 59.227 µM 0.504560399757062 0.311394064917999 no 1059 0.306933814757805 1490 88733
SGTC_1121 fusaric acid 630.51 nM 0.504380855641639 0.311458181525871 no 1060 0.306996884245938 1449 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2443 5493264 126.67 µM 0.503132730907827 0.311904054596585 no 1061 0.307435477938867 1574 5340055
SGTC_2109 5483026 200 µM 0.502505902567779 0.312128083309443 no 1062 0.307655850714087 1510 759335
SGTC_926 2268-1401 59.4 µM 0.501338644633024 0.312545446942162 no 1063 0.30806640619392 1440 2931578
SGTC_2997 9067075 71.4286 µM 0.499500989700847 0.31320300438324 no 1064 0.308713244861607 1535 27209819
SGTC_1429 4049-0205 9.46 µM 0.497888881723286 0.313780345244868 no 1065 0.309281182130429 1493 22774478
SGTC_1976 st070609 63.5 µM 0.496873893354822 0.314144075091207 no 1066 0.309638991280511 1453 682556
SGTC_2674 ligustilide 100 µM 0.492970806822464 0.315544459859904 no 1067 0.31101660743325 1482 5319022 A signalling regulator.
SGTC_1646 st011709 75.6 µM 0.486396500174608 0.317909240550448 no 1068 0.313343035742997 1547 5757843
SGTC_2524 avocatin b 10.57 µM 0.486250698149626 0.317961770329002 no 1069 0.313394714967458 1548 6710748
SGTC_3354 9151612 71.43 µM 0.486030647665796 0.318041057392489 no 1070 0.313472718341314 1581 27261949
SGTC_1122 capsaicin 818.572 nM 0.484907021743353 0.318446044449988 no 1071 0.313871150641703 1594 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2372 9071633 200 µM 0.484882804919306 0.318454775279923 no 1072 0.313879740201842 1534 21321366
SGTC_386 1509-0011 3.07 µM 0.484754889086977 0.318500894122035 no 1073 0.313925112842593 1500 3107280
SGTC_2838 9002687 71.43 µM 0.483939089301913 0.318795089148224 no 1074 0.314214548901712 1460 6457060
SGTC_2523 spermine 47.74 µM 0.479258961387971 0.320485047139164 no 1075 0.315877206685875 1595 1103 A DNA binding polyamine.
SGTC_2775 cyproheptadine 69.59 µM 0.478792231095521 0.320653784871567 no 1076 0.316043222036459 1511 2913 A selective serotonin reuptake inhibitor.
SGTC_1156 4092-0367 4.88 µM 0.478633581792982 0.320711150045043 no 1077 0.316099661835386 1532 1357585
SGTC_870 0573-2213 57.6 µM 0.477349204880558 0.321175718739807 no 1078 0.316556739131359 1472 3916321
SGTC_2355 9061122 103.12 µM 0.476903127874314 0.321337133662165 no 1079 0.316715552283579 1603 5302957
SGTC_2904 7225135 42.03 µM 0.475736044481537 0.32175960751459 no 1080 0.317131219233172 1555 4446116
SGTC_671 0560-0003 407 µM 0.475105139437807 0.321988085595139 no 1081 0.317356017734246 1551 3238678
SGTC_891 0929-0073 133 µM 0.47481256777499 0.322094061332003 no 1082 0.317460287156244 1567 5603632
SGTC_966 1300-0360 30.2 µM 0.472606827544339 0.322893492964371 no 1083 0.318246855258527 1526 70588
SGTC_852 0418-0143 439 µM 0.472270134310727 0.323015593628554 no 1084 0.318366992483847 1546 5369229
SGTC_3009 9080819 71.4286 µM 0.472207975652378 0.323038137342331 no 1085 0.318389173720288 1512 17027216
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.46987882307542 0.323883342779589 no 1086 0.319220797481445 1489 23665772 A membrane-active detergent.
SGTC_1496 4469-0713 57.4 µM 0.469198999053604 0.324130209619792 no 1087 0.319463700443508 1598 746691
SGTC_1296 1068-0102 11.9 µM 0.468799208725047 0.324275422986222 no 1088 0.319606582800451 1574 767053
SGTC_400 oxethazaine 37.5 µM 0.467894171551989 0.32460425276447 no 1089 0.319930135869539 1510 4621 A local anesthetic.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.467271613065169 0.324830528161044 no 1090 0.320152781666053 1562 368090
SGTC_2288 7946289 167.31 µM 0.466716988880619 0.32503216657995 no 1091 0.320351186658411 1657 1246052
SGTC_3344 9148862 3.898 µM 0.464549139258422 0.325820798344551 no 1092 0.321127181005871 1613 4905352
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.46429631701126 0.325912822208904 no 1093 0.321217731160403 1488 4174840
SGTC_630 4356-0227 183 µM 0.463056697832409 0.326364180152336 no 1094 0.321661863669743 1540 779312
SGTC_396 dithiazanine 1.25 µM 0.462932551772834 0.326409397019057 no 1095 0.321706356952443 1478 10578 An antihelmenthic.
SGTC_1402 3909-7673 35.9 µM 0.462862816184216 0.326434797452612 no 1096 0.321731350935503 1491 5328014
SGTC_87 0100-0052 35.5 µM 0.462390432671719 0.326606879222012 no 1097 0.321900679491316 1596 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1873 rapamycin 2 nM 0.461752907825209 0.326839177841091 no 1098 0.32212926253876 1524 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1314 1222-0010 41.1 µM 0.461751496116714 0.326839692308009 no 1099 0.322129768778254 1552 3526027
SGTC_1741 st038134 10.228 µM 0.461514421493876 0.326926093744161 no 1100 0.322214788557506 1664 1272587
SGTC_2884 9058502 51.95 µM 0.459900751296494 0.327514439391053 no 1101 0.322793730459479 1508 6471554
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.45693977128685 0.328595129477017 no 1102 0.323857168302374 1525 689007
SGTC_120 rhodamine 6G 52.259 µM 0.456777025902976 0.328654569516508 no 1103 0.32391566022004 1517 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2905 7799065 20.05 µM 0.45657783788601 0.328727325520751 no 1104 0.323987255812527 1610 1296806
SGTC_2518 prenyletin 46.28 µM 0.456132494589555 0.328890016410925 no 1105 0.324147352331804 1542 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1518 st038567 90.8 µM 0.452542067847775 0.330202837869873 no 1106 0.325439261271803 1531 77966
SGTC_999 SEC7.066 22.7 µM 0.452374881634417 0.330264019791869 no 1107 0.325499469581128 1602 740511 YDR170C SEC7
SGTC_249 wiskostatin 11.211 µM 0.45218890953543 0.330332081754885 no 1108 0.325566448549561 1608 2775510 A n-wasp and actin depolymerizer.
SGTC_1240 0356-0016 42.1 µM 0.450887660502152 0.33080846908335 no 1109 0.326035258693544 1587 4305613
SGTC_863 0466-0191 129 µM 0.450498988923117 0.330950814971673 no 1110 0.326175341530827 1613 765160 YPR165W RHO1
SGTC_2482 5981709 142.65 µM 0.450244385771324 0.331044073300912 no 1111 0.326267117473573 1583 877755
SGTC_2099 5377090 177.372 µM 0.450115635979875 0.331091236922317 no 1112 0.32631353148411 1524 2243829
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.450112214631174 0.331092490267274 no 1113 0.326314764909322 1490 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1811 st050069 61.5 µM 0.449914540700422 0.331164907503713 no 1114 0.326386031262014 1571 3877702
SGTC_2898 9056270 58.44 µM 0.448009345713747 0.331863193244412 no 1115 0.327073225901654 1545 19154699
SGTC_3313 9133968 57.047 µM 0.447266130775988 0.332135752528517 no 1116 0.327341459158299 1537 1494643
SGTC_3049 9092223 49.47 µM 0.446196453507467 0.332528191274762 no 1117 0.327727672250201 1569 8623917
SGTC_553 k007-0256 45.7 µM 0.445608917220616 0.33274382230249 no 1118 0.327939884056414 1576 6287000
SGTC_2296 7971656 126.45 µM 0.445442499904362 0.332804908993639 no 1119 0.328000002307518 1544 666570
SGTC_441 propafenone 146 µM 0.444892549485431 0.333006810482196 no 1120 0.328198703573515 1531 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_821 1114-0266 29.2 µM 0.444708681261707 0.333074324221686 no 1121 0.328265147408065 1545 3123235
SGTC_3324 9138759 60.749 µM 0.444512374735802 0.333146411096971 no 1122 0.328336092026455 1573 45595710
SGTC_2269 7935389 174.42 µM 0.442467791085331 0.333897580762936 no 1123 0.329075366344608 1503 97605
SGTC_147 4466-0538 29.23 µM 0.441722613629262 0.334171520961567 no 1124 0.329344971836753 1599 6742687 YHR072W ERG7
SGTC_2172 5754775 163.918 µM 0.441297474791595 0.334327848990953 no 1125 0.329498827004943 1507 2263357
SGTC_327 1273-0057 3.96 µM 0.438641180352149 0.335305246227335 no 1126 0.33046077663317 1553 3108138
SGTC_3351 9150312 21.596 µM 0.438072753959852 0.335514546822291 no 1127 0.330666772245327 1556 4904905
SGTC_2774 tamoxifen 10.92 µM 0.436609629145975 0.336053519512739 no 1128 0.331197239084132 1580 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_721 1187-1332 279 µM 0.435547921682066 0.336444832941401 no 1129 0.331582381349212 1521 25730
SGTC_3085 9117376 49.47 µM 0.435516916907979 0.336456263033532 no 1130 0.331593631239969 1620 16480349
SGTC_465 cgp-37157 41 µM 0.434648123652388 0.336776610190355 no 1131 0.331908929241373 1638 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1104 tacrolimus 29.8 µM 0.433165682128338 0.337323499189717 no 1132 0.332447204185522 1581 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3192 9110362 49.47 µM 0.432749132589994 0.337477230838405 no 1133 0.332598515711385 1614 16649480
SGTC_754 3474-0146 171 µM 0.431768119507899 0.337839390383179 no 1134 0.332954976223847 1479 24762078
SGTC_177 1327-0068 8.361 µM 0.431178165179974 0.33805725552398 no 1135 0.33316941452192 1545 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_5 0352-0601 109.883 µM 0.43056983893332 0.338281962070126 no 1136 0.333390587826839 1591 762456
SGTC_3196 9111891 49.47 µM 0.430271145534441 0.338392316002926 no 1137 0.333499207027026 1551 18891510
SGTC_1379 2144-0755 36.5 µM 0.430048789025242 0.338474475862269 no 1138 0.333580075549575 1678 5392327
SGTC_2426 5582046 32.21 µM 0.429974002353929 0.338502110972645 no 1139 0.333607276345763 1610 2251934
SGTC_2770 toltrazuril 17.5 µM 0.429895337312364 0.338531180153798 no 1140 0.333635888694953 1637 68591 Kills coccidiodes.
SGTC_1912 st060209 90.8 µM 0.428831836132596 0.338924271304173 no 1141 0.334022804312802 1524 688787
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.428027981262211 0.339221508485234 no 1142 0.334315374353941 1531 6708514
SGTC_2029 5175081 200 µM 0.427530551705572 0.339405490533038 no 1143 0.334496468648466 1560 1380876
SGTC_987 1497-1013 404 µM 0.427263412560051 0.339504311899939 no 1144 0.334593739273353 1619 1676435
SGTC_748 act1.228 77.9 µM 0.426890978274246 0.339642102957255 no 1145 0.334729368461608 1521 4421505 YNR035C ARC35
SGTC_2616 abietic acid 100 µM 0.426594480514021 0.339751814789175 no 1146 0.334837359306025 1670 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_840 0245-0196 390 µM 0.425725409900412 0.340073471562773 no 1147 0.335153972136366 1660 3827528
SGTC_2391 6285546 200 µM 0.425454515364219 0.340173757727765 no 1148 0.335252686220825 1555 846083
SGTC_587 k089-0003 57 µM 0.42149457809428 0.341641028765845 no 1149 0.336696984767592 1616 9659696
SGTC_2491 paeonol 100 µM 0.419031216051605 0.342554985924412 no 1150 0.337596659407871 1570 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2467 5474540 200 µM 0.418430386082215 0.342778046157792 no 1151 0.337816237006422 1553 5413519
SGTC_1762 st045503 25.4615 µM 0.418335359139481 0.3428133302666 no 1152 0.337850970338744 1586 4645554
SGTC_1501 4491-0275 38.4 µM 0.417984828847288 0.34294349625098 no 1153 0.337979104731801 1683 5104718
SGTC_2004 4023728 41.89 µM 0.417323294732959 0.343189201234888 no 1154 0.338220975978822 1708 360084 YDR527W RBA50
SGTC_513 4245-1575 41.7 µM 0.416556681599861 0.343474017286717 no 1155 0.338501349930579 1686 719745
SGTC_2879 9041815 71.43 µM 0.416257681558357 0.343585127426848 no 1156 0.338610727704452 1575 4942971
SGTC_2150 5556613 200 µM 0.414834743293224 0.344114084562577 no 1157 0.339131441879684 1622 743190
SGTC_937 3122-0005 46.7 µM 0.414273213475713 0.344322909347726 no 1158 0.339337014392374 1718 759535
SGTC_686 1319-0111 510 µM 0.413511924151954 0.344606097587877 no 1159 0.339615793960751 1706 4562600
SGTC_2960 9079389 5.97 µM 0.412601726514212 0.344944791819476 no 1160 0.339949218052316 1727 16457355
SGTC_317 4495-0002 170 µM 0.41197902124154 0.345176578695273 no 1161 0.340177399949708 1586 15991618
SGTC_3165 9101544 49.47 µM 0.410583222750832 0.34569634163333 no 1162 0.340689083948156 1661 5002184
SGTC_1348 1493-0373 93.8 µM 0.410465201255236 0.345740303452883 no 1163 0.340732362759764 1639 3010129
SGTC_2387 9077560 195.08 µM 0.408067594539275 0.346633837449366 no 1164 0.34161202506721 1573 5303272
SGTC_693 4161-2696 114 µM 0.405657567068816 0.347532861050702 no 1165 0.342497112212991 1705 805759
SGTC_3350 9150499 3.57 µM 0.405537236020894 0.347577771230412 no 1166 0.342541326745169 1593 4910996 YPR165W RHO1
SGTC_1309 pyrazolanthrone 13.4 µM 0.405431485798688 0.347617241293207 no 1167 0.342580185468956 1710 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2791 5663188 71.43 µM 0.405065259550485 0.347753943822147 no 1168 0.342714770963901 1708 54690634
SGTC_2619 obliquin 87.91 µM 0.405002481982317 0.347777379008526 no 1169 0.342737843270812 1706 6708593 A bioactive alkalod. YER133W GLC7
SGTC_350 k064-0020 19.8 µM 0.404420881290983 0.347994521156507 no 1170 0.34295162377286 1714 2790705
SGTC_1209 2323-2347 50.3 µM 0.403260497251666 0.348427902492632 no 1171 0.343378299398822 1667 5412760
SGTC_1997 st073024 93.8 µM 0.403233323670114 0.348438053681834 no 1172 0.34338829357625 1678 686268
SGTC_2171 5739187 198.077 µM 0.40173151980255 0.348999248627143 no 1173 0.343940812443174 1564 2262761
SGTC_2011 4012611 177 µM 0.401575842475942 0.349057441143666 no 1174 0.343998105765155 1577 2049887
SGTC_257 daunorubicin 18.5 µM 0.400572509464212 0.349432574272121 no 1175 0.344367444400005 1749 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2061 5245884 80.95 µM 0.399382724858468 0.349877609864498 no 1176 0.344805610444816 1616 573863
SGTC_1522 st012842 45.6 µM 0.398410674064933 0.350241355909847 no 1177 0.345163745514579 1529 3491067 YOR116C RPO31
SGTC_582 0987-0078 156 µM 0.397024455852161 0.350760323037442 no 1178 0.345674713213493 1627 1625765
SGTC_2977 9011197 71.43 µM 0.396090046068209 0.351110301089171 no 1179 0.346019300590425 1680 2704722
SGTC_1508 1080-0625 72.9 µM 0.39581386249046 0.351213768330677 no 1180 0.346121174744753 1631 767111
SGTC_1194 1488-0194 225 µM 0.39393381098386 0.351918388757517 no 1181 0.346814953505817 1631 1391452
SGTC_1165 k072-0275 30.3 µM 0.392706834028359 0.352378519371803 no 1182 0.347268011273161 1658 6153523 YGL055W OLE1
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.391947088244057 0.352663541266365 no 1183 0.347548654752566 1617 279621
SGTC_2136 5328288 199.296 µM 0.387889564854206 0.354187135843953 no 1184 0.349048880386484 1617 262395
SGTC_2027 5150920 200 µM 0.387272062693641 0.354419212578832 no 1185 0.34927740286439 1702 786715
SGTC_2601 securinine 100 µM 0.386142124404135 0.354844018857037 no 1186 0.349695706902746 1609 442872 A GABA receptor antagonist.
SGTC_1332 1480-0653 17.5 µM 0.385790721435443 0.354976167492088 no 1187 0.349825833792119 1746 5749438
SGTC_1361 1608-0041 5.61 µM 0.385097297673422 0.355236987673921 no 1188 0.350082665030448 1613 X1361
SGTC_1770 st043884 66.3 µM 0.384841826020321 0.355333096327327 no 1189 0.350177304265737 1642 670149
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.382550365202704 0.356195556598418 no 1190 0.351026589197025 1730 688761
SGTC_1583 clindamycin 39.6 µM 0.382041490579969 0.356387186938552 no 1191 0.351215294779309 1570 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2688 kanamycin b 96.69 µM 0.380869648784457 0.356828613140328 no 1192 0.35164998742353 1656 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_155 k072-0202 43.6 µM 0.380479674375937 0.356975556863298 no 1193 0.351794690801815 1705 5857737
SGTC_2337 9009472 200 µM 0.379093928121855 0.357497882451831 no 1194 0.352309057522922 1748 5742383
SGTC_1789 tunicamycin 25 nM 0.379038644379124 0.357518725949244 no 1195 0.352329583571136 1726 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_769 0302-0231 76 µM 0.377662284757302 0.358037788389119 no 1196 0.352840744361808 1706 571869 YER009W NTF2
SGTC_703 3875-0075 71.8 µM 0.374473912341386 0.359241216991543 no 1197 0.354025880992262 1711 2850814
SGTC_1688 st021091 57.6 µM 0.374279995024041 0.359314454923094 no 1198 0.354098006970128 1777 3656366
SGTC_1312 1218-2183 165 µM 0.372156169533161 0.360116910811968 no 1199 0.354888288820888 1704 6744073
SGTC_235 0330-0087 5 mM 0.371445075448766 0.360385725141756 no 1200 0.355153028856049 1669 46494818 YHR062C RPP1
SGTC_14 0354-0009 295 µM 0.371403123673395 0.360401586295512 no 1201 0.355168649670569 1714 1713507
SGTC_2159 5658611 73.75 µM 0.371117690337551 0.360509509488117 no 1202 0.355274937716294 1757 793844
SGTC_2966 9084041 48.03 µM 0.370192566785742 0.360859377793571 no 1203 0.355619507323188 1504 17741380
SGTC_2558 carylophyllene oxide 100 µM 0.370062988344109 0.360908391786098 no 1204 0.355667779271178 1708 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1574 spiramycin 23.7 µM 0.369761303735564 0.361022515043205 no 1205 0.355780175017736 1617 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_1986 st071812 45 µM 0.367799739133583 0.361764850084593 no 1206 0.356511281775017 1664 11838594
SGTC_2028 5153890 36.43 µM 0.367608049374313 0.361837421170485 no 1207 0.356582755980102 1651 2830968 YPR165W RHO1
SGTC_1529 apigenin 74 µM 0.365557226447706 0.362614144763674 no 1208 0.35734774870136 1780 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2272 7805186 180 µM 0.365410496200831 0.362669738737404 no 1209 0.35740250366832 1794 2956062 YPR165W RHO1
SGTC_1725 st036284 20.55 µM 0.363020474633537 0.363575690321722 no 1210 0.358294794808184 1828 707914
SGTC_2405 ticlatone 3.52 µM 0.361217087821172 0.364259780253443 no 1211 0.358968584533225 1473 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_2540 epiandrosterone 100 µM 0.360137197313603 0.364669629099373 no 1212 0.359372268518433 1697 441302 A steroid.
SGTC_2896 9052656 71.43 µM 0.359136701529997 0.365049483508055 no 1213 0.35974641336118 1691 6469436
SGTC_500 h-89 112 µM 0.356546483396461 0.366033516325341 no 1214 0.360715673748137 1828 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.355483107276852 0.366437752290968 no 1215 0.361113849025044 1679 5106787 A p450 inhibitor.
SGTC_2678 equilin 100 µM 0.353655278948619 0.367132936273624 no 1216 0.361798620742819 1805 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1603 st002045 67.8 µM 0.353247845049851 0.367287956436629 no 1217 0.361951320888356 1807 5887985
SGTC_2563 tomatine 8.54 µM 0.352747441994027 0.367478379039191 no 1218 0.362138894558342 1948 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1243 0416-0003 5.65 µM 0.35204713627978 0.367744927000495 no 1219 0.362401456362451 1687 2141977
SGTC_2097 5376186 200 µM 0.350831560392973 0.368207746537679 no 1220 0.362857359253881 1798 742755
SGTC_464 bw-b 70c 158 µM 0.349533524606038 0.368702173175946 no 1221 0.363344403496574 1784 5353454
SGTC_2198 6589944 200 µM 0.349435059662057 0.368739687719621 no 1222 0.363381358181022 1752 5290268
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.348981744052863 0.368912414334449 no 1223 0.363551507567853 1682 688667
SGTC_3118 9124250 49.47 µM 0.348275541824379 0.369181550953915 no 1224 0.363816630104696 1693 1504786
SGTC_193 1273-0060 1.558 µM 0.347735687823115 0.369387334833551 no 1225 0.36401934615586 1771 2847393 YHR072W ERG7
SGTC_1261 0712-0010 12.7 µM 0.347445550211608 0.369497946207996 no 1226 0.364128309025355 1818 2840123
SGTC_509 pifithrin 175 µM 0.344720208741365 0.370537475070538 no 1227 0.365152361986447 1758 4817 A p53 inhibitor.
SGTC_717 1532-0246 73.2 µM 0.34432958782366 0.370686547560536 no 1228 0.365299217665326 1693 9561992
SGTC_2508 celastrol 40.54 µM 0.342945540464471 0.371214897079989 no 1229 0.365819715310206 1699 122724 Celastrol is a natural product and antioxidant.
SGTC_838 0109-0203 71.4 µM 0.342943307789538 0.371215749583033 no 1230 0.365820555150455 1701 759422
SGTC_711 k292-0785 179 µM 0.341882075927331 0.371621031576207 no 1231 0.366219819547276 1668 4146315
SGTC_741 4582-0002 126 µM 0.34186072206819 0.371629188027972 no 1232 0.366227854940359 1675 2912688
SGTC_1863 st057641 20.1 µM 0.340189086992284 0.372267874645155 no 1233 0.366857067973587 1827 3921635
SGTC_1275 0867-0008 21.1 µM 0.339998616005064 0.372340670806086 no 1234 0.36692878508962 1741 3422836
SGTC_279 1273-0055 2.93 µM 0.33840785655892 0.372948821523476 no 1235 0.367527927176023 1846 2847562
SGTC_403 arphamenine a 50 µM 0.337825594132748 0.373171500956609 no 1236 0.367747310655089 1757 5487158 An arginine aminopeptidase inhibitor.
SGTC_413 propylparaben 100 µM 0.337430507732526 0.373322621248828 no 1237 0.367896194968805 1676 7175 A pharmaceutical preservative.
SGTC_221 trifluoperazine 10.304 µM 0.336817979771909 0.373556951315169 no 1238 0.368127059170554 1719 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2451 5856223 45.7 µM 0.336728639427743 0.373591133466347 no 1239 0.368160735880661 1680 2179896
SGTC_1742 st038235 28.8875 µM 0.334399076737811 0.374482788429556 no 1240 0.369039218002757 1720 564103 YBR002C RER2
SGTC_2734 clemastine 41.6 µM 0.332748034275327 0.375115142466001 no 1241 0.369662243765237 1777 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1092 toremifene 6.32 µM 0.331946199042528 0.37542236893256 no 1242 0.369964942271517 1757 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1991 st073000 8.92 µM 0.329297549982513 0.376437770409447 no 1243 0.370965397891107 1808 4301969 YIL048W NEO1
SGTC_3147 9097027 49.47 µM 0.32837708942443 0.376790844222073 no 1244 0.371313281718701 1796 25236841
SGTC_497 capsazepine 133 µM 0.32767179533331 0.377061453416615 no 1245 0.371579915549591 1647 2733484 A calcium channel blocker.
SGTC_1460 k062-0059 9.15 µM 0.326789217092261 0.377400168546768 no 1246 0.371913657796432 1672 1373085
SGTC_3020 9089140 49.47 µM 0.32605417043394 0.377682336137865 no 1247 0.372191685250237 1725 17217859
SGTC_1148 3909-7663 27.7 µM 0.325240689256805 0.377994689051818 no 1248 0.372499457821777 1838 4084526
SGTC_611 3453-1652 23.7 µM 0.324567178265174 0.378253357895388 no 1249 0.372754335690104 1838 1560575
SGTC_2795 7780010 54.55 µM 0.324250442268506 0.378375022496833 no 1250 0.372874217882888 1753 953673
SGTC_3107 9121808 49.47 µM 0.324003535091641 0.378469872823272 no 1251 0.372967678933261 1855 662681
SGTC_2049 5262831 67.185 µM 0.321930638886511 0.379266472026136 no 1252 0.373752620657267 1728 763417
SGTC_2234 tolnaftate 200 µM 0.321258168049691 0.37952500811563 no 1253 0.374007377291767 1799 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1300 1094-0077 113 µM 0.320738912474567 0.379724676400674 no 1254 0.374204128027136 1714 5532636
SGTC_1804 st050076 49.1 µM 0.320240910173881 0.379916202339532 no 1255 0.374392856487202 1792 3895976
SGTC_313 3474-0040 5.03 µM 0.319503996566361 0.38019966484345 no 1256 0.374672180632004 1721 1043375 YIL048W NEO1
SGTC_816 0325-0417 81.3 µM 0.31865872899178 0.380524886219177 no 1257 0.374992656896397 1722 68101
SGTC_1982 st072467 71.9 µM 0.316475846262731 0.381365152607953 no 1258 0.375820677826701 1721 3163533
SGTC_720 r052-1644 49.9 µM 0.316179354157105 0.381479325829978 no 1259 0.375933188768916 1751 1422863 YOR257W CDC31
SGTC_295 k015-0027 31 µM 0.31567266836424 0.381674464336139 no 1260 0.376125487087416 1789 3887424
SGTC_345 1362-0200 395 µM 0.315627465268722 0.381691874741977 no 1261 0.376142644144037 1695 1419823
SGTC_131 0141-0277 33.849 µM 0.312726333684286 0.382809772555918 no 1262 0.377244293477675 1852 1547771
SGTC_2009 4012297 12.05 µM 0.312524087288534 0.382887741027331 no 1263 0.377321130066152 1727 45595307
SGTC_2450 5739737 12.93 µM 0.312143144638962 0.383034611986481 no 1264 0.377465869360664 1762 2262825
SGTC_801 0866-0028 10.1 µM 0.311405071928093 0.383319220892151 no 1265 0.37774634931068 1772 6849771
SGTC_2752 diclazuril 33.15 µM 0.31139561782166 0.383322866907807 no 1266 0.377749942447438 1872 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_560 2332-1943 155 µM 0.309920745612586 0.383891783901677 no 1267 0.378310613154963 1763 21177716
SGTC_2624 nerol 100 µM 0.309919422904833 0.383892294235307 no 1268 0.378311116095769 1840 637566 A natural product oil.
SGTC_2868 9035608 32.47 µM 0.30971340320192 0.383971784230855 no 1269 0.378389454673244 1709 6462614
SGTC_656 4090-1979 187 µM 0.309512719056758 0.384049220265216 no 1270 0.378465769221848 1888 22330961
SGTC_562 3772-2733 112 µM 0.308222829674879 0.384547047676039 no 1271 0.378956390987523 1866 2876874 YIL048W NEO1
SGTC_90 0870-0863 4.608 µM 0.306277132142746 0.385298341595197 no 1272 0.379696824519495 1723 1738164
SGTC_2385 9074692 200 µM 0.305613571498419 0.385554661486602 no 1273 0.379949443013357 1741 17046906
SGTC_1559 coumarin 343 70.1 µM 0.304907389838549 0.38582749991253 no 1274 0.380218343663327 1839 108770 A hepatotoxic, DNA x-linker.
SGTC_2881 9058953 51.95 µM 0.304905930419849 0.38582806382811 no 1275 0.380218899442428 1741 17122249
SGTC_170 4197-0004 226 µM 0.304791788998408 0.385872168522989 no 1276 0.380262367800431 1842 218692
SGTC_1330 1469-0054 61.8 µM 0.303822644425978 0.386246709192619 no 1277 0.380631506992994 1916 7102664
SGTC_2110 5483698 200 µM 0.303804497937353 0.38625372319161 no 1278 0.380638419878962 1786 2848765 YHR062C RPP1
SGTC_3130 9127414 49.47 µM 0.301944313694964 0.386972920293042 no 1279 0.381347256950563 1786 1494646
SGTC_47 0149-0135 24.25 µM 0.299805106622853 0.38780047496601 no 1280 0.382162909942939 1653 5239155
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.299140306450407 0.388057757693187 no 1281 0.382416496700148 1818 1377
SGTC_3156 9099931 49.47 µM 0.298363643147596 0.388358394538147 no 1282 0.382712817307 1784 18111053
SGTC_2024 5144227 134 µM 0.298268992340085 0.388395037282478 no 1283 0.382748934158714 1848 3475211
SGTC_1872 amphotericin b 148 nM 0.296373492159844 0.389129062548022 no 1284 0.383472433329404 1875 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2943 9068529 45.32 µM 0.29595689407878 0.389290441730777 no 1285 0.383631500484481 1816 3270634
SGTC_2255 7941087 197.44 µM 0.295850107069151 0.389331811296803 no 1286 0.38367227748917 1912 935561
SGTC_2152 5568786 200 µM 0.295390222029601 0.389509986287779 no 1287 0.383847900965112 1811 5399883
SGTC_2927 9011802 47.9 µM 0.295188673272092 0.389588080404 no 1288 0.383924877055652 1712 43912568
SGTC_395 anisomycin 6.25 µM 0.293931811415064 0.39007517726259 no 1289 0.38440500462694 1785 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_348 k064-0012 10.7 µM 0.292958484543212 0.390452508791723 no 1290 0.384776942328509 1751 5066323
SGTC_733 4069-0007 56.1 µM 0.292090336688459 0.390789152458268 no 1291 0.385108777446305 1823 5717425 YNL287W SEC21
SGTC_3222 9128301 49.47 µM 0.29190396115005 0.390861434407039 no 1292 0.385180027385084 1762 4911358
SGTC_2835 9006588 71.43 µM 0.291472073270573 0.391028947796152 no 1293 0.385345149704048 1752 2345538
SGTC_2483 5729050 27.16 µM 0.290637634399675 0.391352653122611 no 1294 0.385664236918297 1924 2865180
SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.2893275870952 0.391861013816446 no 1295 0.386165351594676 1875 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_1358 1509-0022 2.48 µM 0.28804141471951 0.392360289580537 no 1296 0.386657518535271 1836 3258434
SGTC_1565 sinapyl alcohol 95.1 µM 0.286672872320936 0.392891734953949 no 1297 0.387181405445587 1729 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1249 0481-0015 10.2 µM 0.28408944355077 0.393895500162444 no 1298 0.388170918328909 1758 4227577
SGTC_815 1582-0027 36.9 µM 0.283489164749594 0.394128833667467 no 1299 0.388400943210599 1844 3128206
SGTC_1009 4106-0057 9.87 µM 0.282366234457102 0.39456542826219 no 1300 0.388831351495123 1940 2928005
SGTC_1389 3405-0187 19 µM 0.281590617597639 0.394867064994382 no 1301 0.389128717639182 1760 799890
SGTC_1702 st027038 51 µM 0.280548220168163 0.395272551707207 no 1302 0.389528467888669 1838 5521182
SGTC_2244 6635614 200 µM 0.280332387624957 0.395356523535471 no 1303 0.389611252395396 1807 836499
SGTC_1350 1495-0454 146 µM 0.275512050401514 0.397233183570285 no 1304 0.391461434524667 1910 1069057
SGTC_1931 st074438 57.1 µM 0.275330990681725 0.397303720658994 no 1305 0.391530978540885 1857 2787313
SGTC_298 1391-0729 10 µM 0.274143442665189 0.397766447746961 no 1306 0.391987194874768 1811 3237558
SGTC_2227 7312221 64.1025 µM 0.273763670250422 0.397914456141154 no 1307 0.39213312214529 1900 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2341 7987486 176.74 µM 0.27367375944782 0.397949499156962 no 1308 0.392167672526915 1972 1258686
SGTC_2749 bexarotene 57.39 µM 0.273028790981361 0.39820090174818 no 1309 0.392415542031706 1756 82146 An retinoic acid receptor inhibitor.
SGTC_1132 3456-3614 2.5 µM 0.272755620824246 0.398307393631961 no 1310 0.39252053792869 1989 3125502
SGTC_2809 7964133 12.99 µM 0.272618599907403 0.39836081233276 no 1311 0.39257320634305 1833 1253665
SGTC_1075 aripiprazole 15.2 µM 0.272614597585323 0.398362372698682 no 1312 0.39257474479437 1806 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2875 9039966 71.43 µM 0.272373788422355 0.398456258790133 no 1313 0.392667312440509 1919 6463691
SGTC_1966 st070145 16.1 µM 0.269607878620146 0.399535045157546 no 1314 0.393730969236534 1781 3748532
SGTC_543 3844-1095 191 µM 0.269056813530815 0.399750068736885 no 1315 0.393942981565901 1897 4230703
SGTC_2878 9043973 25.97 µM 0.268241739314583 0.400068163438052 no 1316 0.394256624252191 1934 6465167
SGTC_2289 7946404 165.07 µM 0.268230838631507 0.40007241803979 no 1317 0.394260819328659 1801 1246120 YPR165W RHO1
SGTC_690 glyoxal 20.3 µM 0.266035520346335 0.400929504955337 no 1318 0.395105926570018 1854 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2235 salicylic acid 500 µM 0.26356973617847 0.401892754743049 no 1319 0.396055740566245 1911 338 A COX inhibitor and kinase inhibitor.
SGTC_1256 0570-0116 285 µM 0.263514035584897 0.401914520889743 no 1320 0.396077203450022 1762 410638
SGTC_450 aminopyrene 156 nM 0.263488921987174 0.401924334641442 no 1321 0.396086880473805 1932 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1941 st076221 61.8 µM 0.263460131701536 0.401935585224825 no 1322 0.396097974314696 1975 2828568
SGTC_886 0866-0150 153 µM 0.263260370945112 0.402013649384827 no 1323 0.396174950999934 1985 271463
SGTC_1433 4060-0023 7.6 µM 0.263230117608676 0.40202547237469 no 1324 0.396186609306213 1902 3840627
SGTC_525 k781-2675 26.7 µM 0.26260781454097 0.402268687998602 no 1325 0.39642643814126 1879 3651118 YDL195W SEC31
SGTC_1039 k821-0043 94 µM 0.262495630911524 0.402312536920098 no 1326 0.396469676664523 1944 15992768
SGTC_229 benomyl 22.8748 µM 0.262252512695245 0.402407568118645 no 1327 0.396563385192573 1831 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_3163 9099914 49.47 µM 0.261379776431325 0.40274875487643 no 1328 0.396899825586335 1931 16268368
SGTC_448 monastrol 171 µM 0.260474395582848 0.403102781962978 no 1329 0.397248931601719 1910 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_913 3487-1245 167 µM 0.260466771089131 0.403105763672909 no 1330 0.397251871882049 1757 4016153
SGTC_273 hydroxyurea 18.1 mM 0.259405121613956 0.403520997752218 no 1331 0.397661339228956 1852 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_868 0527-0199 213 µM 0.259362646829486 0.403537612825594 no 1332 0.397677723668241 1852 2849450
SGTC_3043 9092303 49.47 µM 0.259284073481423 0.403568349213108 no 1333 0.397708033426722 1770 25236084
SGTC_3045 9092950 49.47 µM 0.258607326464749 0.40383310430999 no 1334 0.39796911490382 1979 44120432
SGTC_1180 1193-0155 285 µM 0.256732058607955 0.404566971292267 no 1335 0.398692810806284 1833 2921347
SGTC_2243 6634756 200 µM 0.256515598900441 0.404651702264829 no 1336 0.398776368554806 1958 885676
SGTC_969 1313-0238 134 µM 0.256436654263374 0.404682605460924 no 1337 0.398806843908306 1828 5212874
SGTC_2751 anetholtrithion 17.25 µM 0.253004509122168 0.406026704784658 no 1338 0.400132364380812 1957 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2354 9060492 162 µM 0.252541688165984 0.406208040243829 no 1339 0.400311197775114 1949 6471895
SGTC_419 nsc-638432 893 µM 0.251285295387154 0.406700402271269 no 1340 0.400796771544644 1869 368090
SGTC_3249 9135183 49.47 µM 0.25108086826109 0.406780528258736 no 1341 0.400875793565219 1906 4902779
SGTC_978 1416-0512 87.4 µM 0.251050865956475 0.406792288104307 no 1342 0.400887391402404 1865 6814003
SGTC_623 k072-0108 16.9 µM 0.248762738245661 0.407689400365078 no 1343 0.401772157864909 1879 5382803
SGTC_1546 5-methoxyflavanone 78.7 µM 0.248345830896881 0.407852910622699 no 1344 0.40193342074931 2005 147795
SGTC_2478 5763493 32.33 µM 0.247604959940705 0.408143518370931 no 1345 0.40222003636757 1908 1365576 YLR208W SEC13
SGTC_2842 9000675 19.48 µM 0.243602151627491 0.409714496140057 no 1346 0.403769480867011 1746 2989072
SGTC_1901 st060216 58.6 µM 0.241860511851885 0.410398489978201 no 1347 0.40444412439612 1822 688792
SGTC_1729 st035615 45.989 µM 0.241683966034415 0.410467840035223 no 1348 0.404512527280262 1842 17385451
SGTC_3279 9140807 49.47 µM 0.240717371846736 0.41084758345863 no 1349 0.404887087014801 1970 45595718
SGTC_842 0271-0008 11.1 µM 0.240631568450522 0.410881296866542 no 1350 0.40492034044597 1939 1221709
SGTC_1810 st050138 53 µM 0.239639728351479 0.411271053058543 no 1351 0.405304781613597 2000 3444541
SGTC_2151 5563267 85.4165 µM 0.239598905230771 0.411287096902865 no 1352 0.405320606778101 1875 5310824
SGTC_3205 9113483 49.47 µM 0.238491631616032 0.411722321642495 no 1353 0.405749902568051 1981 17018033
SGTC_2817 7995342 71.43 µM 0.238380910863094 0.411765847501952 no 1354 0.405792835828648 1819 18879975
SGTC_1102 cgs 12066b 26.1 µM 0.238308255133055 0.411794410064404 no 1355 0.405821009549399 1896 6438352 A 5-HT1B full agonist.
SGTC_1908 st060353 56.5 µM 0.237974370906616 0.411925673289903 no 1356 0.405950486143644 2036 4227716
SGTC_1558 st069300 45.6 µM 0.237902105140149 0.411954085147062 no 1357 0.405978511359978 2001 24208000
SGTC_2058 5236698 133 µM 0.237017899500376 0.412301754910327 no 1358 0.406321452033758 1864 766665
SGTC_49 0717-0965 32.132 µM 0.236555852073565 0.412483459413241 no 1359 0.406500686530719 1968 5889349 YGL099W LSG1
SGTC_182 3448-4371 550.524 µM 0.23623512463413 0.412609599531956 no 1360 0.406625112599367 2078 3491403
SGTC_1625 st003711 30.1 µM 0.23610954330115 0.412658992353323 no 1361 0.406673834391191 1953 24207034 YER133W GLC7
SGTC_141 0443-0274 32.331 µM 0.235788822341964 0.412785142479603 no 1362 0.406798271061388 2023 1627241
SGTC_3266 9136860 49.47 µM 0.235493126971608 0.412901457198165 no 1363 0.406913006380079 1881 4871271 YPR165W RHO1
SGTC_613 3914-0030 117 µM 0.23497715341725 0.41310443884238 no 1364 0.407113232871648 1925 1145395
SGTC_1781 st038725 66.3 µM 0.2329296706891 0.413910137709074 no 1365 0.40790800908492 1822 4270275 YIL048W NEO1
SGTC_2805 7950783 58.44 µM 0.232902439929891 0.413920855654693 no 1366 0.407918581874818 1899 1178958 YDL195W SEC31
SGTC_3338 9144300 39.5675 µM 0.232474030221971 0.414089484872678 no 1367 0.40808492780743 1948 4901274
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.232156376983314 0.414214528722573 no 1368 0.408208279137924 1918 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2348 9022543 33.42 µM 0.231420251611979 0.414504337076226 no 1369 0.408494166810322 1915 3162678 YDL140C RPO21
SGTC_747 3448-8087 38.7 µM 0.229268294377175 0.415351816728421 no 1370 0.409330197306255 1850 5168703
SGTC_2557 derrustone 83.84 µM 0.228300910710225 0.415732918493983 no 1371 0.40970615830432 1818 629853 An antioxidant.
SGTC_3150 9097574 49.47 µM 0.226964051899955 0.416259705756729 no 1372 0.410225847583297 2017 17217476
SGTC_362 0310-0100 9.03 µM 0.226619221347459 0.4163956101811 no 1373 0.410359922320269 1889 790235
SGTC_957 1187-1561 14.1 µM 0.2264494733927 0.4164625148223 no 1374 0.410425926447785 1998 1538454
SGTC_2738 aclarubicin 5.55 µM 0.225948988164998 0.416659790688136 no 1375 0.410620547918093 1971 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2295 7971645 200 µM 0.225424960822404 0.416866368625691 no 1376 0.410824347692569 1948 2978226 YKL099C UTP11
SGTC_3241 9133421 49.47 µM 0.225401687032776 0.416875543968848 no 1377 0.410833399674233 2005 17018221
SGTC_1492 4158-0558 28.5 µM 0.2243842307612 0.417276705063235 no 1378 0.411229169955221 2001 3967268
SGTC_3303 9125618 40.5795 µM 0.223994381912751 0.417430436913428 no 1379 0.411380837380812 1955 22695467
SGTC_2356 9061756 188.97 µM 0.223937992665798 0.417452674328943 no 1380 0.41140277624147 2027 20104043
SGTC_1498 4478-3555 97.6 µM 0.223830445195027 0.417495087008572 no 1381 0.411444619543341 2029 3437919
SGTC_2995 9067767 71.4286 µM 0.223302162361525 0.417703435827964 no 1382 0.411650172216765 1919 11673567
SGTC_1357 1503-1303 39.5 µM 0.218979138517625 0.419409250883201 no 1383 0.413333149224787 1905 292895
SGTC_2485 5633444 17.78 µM 0.217594900468929 0.419955777072533 no 1384 0.413872379065811 1851 5724239
SGTC_2220 6782180 200 µM 0.217174246756661 0.420121890610804 no 1385 0.414036276919822 2018 833803
SGTC_1960 st011366 51.8 µM 0.216805158147678 0.420267653131599 no 1386 0.41418009597438 1960 3972846
SGTC_1237 0330-0133 46.1 µM 0.216445572088699 0.420409673369936 no 1387 0.414320223334045 1898 X1237 YHR072W ERG7
SGTC_1988 st071872 53.4 µM 0.215932887470717 0.42061217853273 no 1388 0.414520030641855 2067 16414116
SGTC_1665 st014639 11.4 µM 0.215487844876827 0.420787982828328 no 1389 0.414693493928402 1976 981133 YIL048W NEO1
SGTC_677 0929-0063 136 µM 0.215388508953223 0.420827225459718 no 1390 0.4147322141481 1969 1539583
SGTC_2747 doxorubicin 7.63 µM 0.214432128504018 0.421205083507241 no 1391 0.415105044688528 2029 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2053 5265679 138 µM 0.213629670752387 0.421522183980361 no 1392 0.415417929790211 1921 764595
SGTC_79 0052-0007 94.094 µM 0.212532897396898 0.421955668962188 no 1393 0.415845657772074 2018 2801472
SGTC_1948 st076329 66.6 µM 0.211785734206074 0.42225102939921 no 1394 0.416137099266328 2034 24208413
SGTC_2521 angolensin 13.4 µM 0.211772559828962 0.422256237743675 no 1395 0.416142238531356 1947 821428 A flavenoid.
SGTC_1820 st053765 18.6 µM 0.209630106041422 0.423103413418575 no 1396 0.416978190233625 1884 3690829
SGTC_1645 Cervolide 78 µM 0.209464726387099 0.423168823188556 no 1397 0.417042734427917 1921 23173 A fragrance.
SGTC_1033 k072-0102 21.3 µM 0.208914505911315 0.423386457663105 no 1398 0.417257489970488 2053 5965931
SGTC_20 0481-0013 4.944 µM 0.208765531900375 0.423445386940124 no 1399 0.417315639992451 1891 182045
SGTC_1014 4130-3005 69.3 µM 0.208559052009048 0.423527066505737 no 1400 0.417396239659464 1886 743608
SGTC_1213 1315-0166 115 µM 0.207217553556738 0.424057817968749 no 1401 0.417919979533779 1812 768401
SGTC_2215 7188065 200 µM 0.206747093364604 0.424243983874564 no 1402 0.418103688346539 2026 940217
SGTC_261 5-fluorouridine 15.376 µM 0.205747983335744 0.424639397942265 no 1403 0.41849388752198 2025 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2736 butenafine 14.65 µM 0.205587617007081 0.424702872603526 no 1404 0.418556525551633 2019 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2502 avocadyne acetate 18.59 µM 0.203553114102308 0.425508318993732 no 1405 0.419351367731863 2053 3952079
SGTC_196 k015-0023 18.111 µM 0.202744893569528 0.425828374706977 no 1406 0.419667215907002 1923 5211998
SGTC_2105 5350118 200 µM 0.202166510645961 0.426057444631017 no 1407 0.419893276583792 1907 2133313
SGTC_2183 6420625 130.508 µM 0.201820155528409 0.426194631344055 no 1408 0.420028661967913 1985 2897619
SGTC_68 0986-0284 82.829 µM 0.20172327668707 0.426233005379955 no 1409 0.420066532250092 1757 423278 YIL048W NEO1
SGTC_1783 st039459 87.517 µM 0.201262885608076 0.426415377379874 no 1410 0.420246510863146 2059 729761
SGTC_2318 6029776 164 µM 0.200914239239258 0.426553495079602 no 1411 0.420382816718297 1992 818325
SGTC_3343 9148379 18.9835 µM 0.200758495784927 0.426615196404147 no 1412 0.420443708850396 2069 1955036
SGTC_2534 helenine 20.12 µM 0.200642321059092 0.426661222843232 no 1413 0.420489131753628 1922 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.198996546703572 0.427313357486387 no 1414 0.421132722952797 1992 676296 Flavone; oxidizing agent.
SGTC_286 k060-0067 22.9 µM 0.198876767417981 0.427360827554752 no 1415 0.421179571703008 1968 5985051
SGTC_782 0083-0095 30.5 µM 0.196526022172778 0.428292670089238 no 1416 0.422099233515435 2025 3591729 An indicator and reagent.
SGTC_1088 bifonazole 369 nM 0.19485931539245 0.428953600348968 no 1417 0.422751542606621 2048 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2662 daunorubicin 22.37 µM 0.19481171866058 0.428972477702089 no 1418 0.422770173946975 2024 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2724 maprotiline 69.64 µM 0.19465047261784 0.429036430747392 no 1419 0.422833293637918 2033 4011 A tricyclic antidepressant.
SGTC_140 0062-0056 502.533 µM 0.194189395755826 0.429219312296713 no 1420 0.423013792894814 1986 3758964
SGTC_3076 9116187 49.47 µM 0.193661970004357 0.429428529101685 no 1421 0.42322028578265 2068 27241210
SGTC_581 0958-0271 211 µM 0.193260219523587 0.429587906926617 no 1422 0.423377589597846 1926 4591145
SGTC_2645 abamectin 100 µM 0.191841915139724 0.43015065191691 no 1423 0.423933018588079 2037 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_394 menadione 8.33 µM 0.19123602305499 0.430391096910111 no 1424 0.424170341035939 2074 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3067 9117431 49.47 µM 0.19122307076048 0.430396237240162 no 1425 0.424175414633031 1935 17150885
SGTC_1765 st044815 90.4 µM 0.191165958180858 0.430418903442733 no 1426 0.424197786588724 1870 645695
SGTC_2654 protoveratrine a 100 µM 0.191054770442 0.430463031047959 no 1427 0.424241341392162 2001 5702278 A heart drug and vasodilator.
SGTC_2776 terbinafine 19.92 µM 0.190424201434026 0.430713304371683 no 1428 0.424488367313078 2062 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3089 9117425 49.47 µM 0.190216349492231 0.430795807070714 no 1429 0.424569799985157 1899 9401657
SGTC_2649 anisomycin 9.56 µM 0.189382748048818 0.431126718914843 no 1430 0.424896422432014 1983 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_944 3370-0224 231 µM 0.188428537893675 0.431505567717106 no 1431 0.425270365176032 1931 4580514
SGTC_488 nitrendipine 139 µM 0.187663317211971 0.431809427824784 no 1432 0.425570293963949 2029 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_531 3788-1495 174 µM 0.187403230971725 0.431912714200037 no 1433 0.42567224476649 1921 2896655
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.18737977617588 0.431922028881106 no 1434 0.425681439019965 2107 756377
SGTC_2880 9042983 58.44 µM 0.187299186523613 0.431954034006097 no 1435 0.425713030380531 1965 6464714
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.187104107914962 0.432031508769359 no 1436 0.42578950369393 1992 6708739 YPR165W RHO1
SGTC_2961 9083290 32.55 µM 0.186626114886856 0.432221353013611 no 1437 0.425976894876913 2072 17741490
SGTC_2439 5492030 7.2 µM 0.186208308578822 0.43238730574969 no 1438 0.426140704303409 2090 5722370
SGTC_1052 3253-3998 198 µM 0.185141302336426 0.432811174874496 no 1439 0.426559103484707 2071 5450317
SGTC_2076 5212012 200 µM 0.18499008145782 0.432871253762242 no 1440 0.426618407579214 2042 604802
SGTC_2245 6637752 200 µM 0.184156874211109 0.433202308361918 no 1441 0.426945195095138 2083 681890
SGTC_2778 tioconazole 65.09 nM 0.183464780899982 0.433477330430244 no 1442 0.42721667524573 2005 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3103 9120822 49.47 µM 0.183365299149988 0.433516864855812 no 1443 0.427255700740248 2070 17141819
SGTC_1674 st016616 23.6 µM 0.182770759917464 0.433753150860685 no 1444 0.427488946161021 1878 625830
SGTC_2704 st078022 71.1 µM 0.182359582749624 0.433916577665795 no 1445 0.427650271106524 2090 54697681
SGTC_2971 9092186 9.93 µM 0.181828164203557 0.434127812436498 no 1446 0.427858790551705 1819 25236400
SGTC_2698 st077697 67.5 µM 0.181150565192072 0.434397180090644 no 1447 0.428124697901225 1921 3154499
SGTC_202 3594-0513 34.79 µM 0.17926123789355 0.435148409651838 no 1448 0.428866290739744 2084 708429
SGTC_2507 purpurin 79.67 µM 0.179218151983815 0.43516554410364 no 1449 0.428883205625631 1881 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2328 6201408 200 µM 0.178586126836298 0.435416902531447 no 1450 0.429131344271698 1964 2890418
SGTC_791 1348-1292 225 µM 0.177198799297794 0.435968738513979 no 1451 0.429676119381126 2063 5437054
SGTC_2226 7298446 200 µM 0.176864400297909 0.436101770781407 no 1452 0.429807451090982 2093 3283010
SGTC_726 3448-4391 34.2 µM 0.176573568595596 0.436217476768946 no 1453 0.429921678516404 2046 1356692
SGTC_2789 5281112 71.43 µM 0.176324984769951 0.436316378969968 no 1454 0.430019317262748 1930 765948
SGTC_139 0099-0334 718.624 µM 0.175625758991461 0.43659459607111 no 1455 0.430293982070552 2140 97690
SGTC_3184 9108758 49.47 µM 0.174132786166072 0.437188744454453 no 1456 0.430880553583752 2031 902885
SGTC_2388 9080168 200 µM 0.17270513210177 0.43775703091521 no 1457 0.431441604790169 1912 15943073
SGTC_433 pimozide 108 µM 0.172275162641324 0.437928208110816 no 1458 0.431610604875155 1851 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2393 9031399 185.94 µM 0.171816586080636 0.438110787016012 no 1459 0.431790862815202 2054 1526623 YDL150W RPC53
SGTC_666 0272-0154 136 µM 0.171319960205186 0.438308529836568 no 1460 0.431986093253862 2018 6870312
SGTC_320 4092-0846 5.34 µM 0.170695485045774 0.438557200596071 no 1461 0.432231606568965 2077 1359356
SGTC_521 r062-0005 13.8 µM 0.167957354504602 0.439647830095439 no 1462 0.433308414288067 1965 2832033
SGTC_2419 paclitaxel 166.5 µM 0.167914846203035 0.4396647652836 no 1463 0.433325135190637 1966 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2759 disulfiram 3.38 µM 0.167518686211369 0.439822599618727 no 1464 0.433480972901789 2008 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3104 9120930 49.47 µM 0.167239363656396 0.439933890432951 no 1465 0.433590856413442 2022 17014836
SGTC_2239 6685329 187.64 µM 0.16659922344214 0.440188960140589 no 1466 0.433842702381321 1973 805680
SGTC_2145 5634607 200 µM 0.16575440440853 0.440525623972986 no 1467 0.434175114830321 1982 308662
SGTC_1940 st075990 51.1 µM 0.163672621142305 0.441355406119086 no 1468 0.434994436008064 2057 1084979
SGTC_1661 st013063 9.66 µM 0.163598147660324 0.441385095444841 no 1469 0.435023751505898 2034 721395
SGTC_1832 st054113 55 µM 0.162686170193717 0.441748687706279 no 1470 0.435382768251724 2128 1251267
SGTC_2918 7977171 22.06 µM 0.162388196654857 0.441867496112753 no 1471 0.435500082589748 2045 2236483
SGTC_2931 9014674 55.67 µM 0.161822314317655 0.442093139860996 no 1472 0.435722890178582 2046 2996810
SGTC_1628 st004252 77.7 µM 0.16128959178658 0.442305578416229 no 1473 0.435932660243381 2096 692968
SGTC_251 melphalan 456.522 µM 0.160583917398683 0.442587012076102 no 1474 0.436210561275644 2066 460612 A DNA alkylator.
SGTC_3003 9075612 71.4286 µM 0.159482375067123 0.44302638174548 no 1475 0.436644421626422 2032 6501993
SGTC_1422 4031-0024 15.5 µM 0.15850135151029 0.443417739372488 no 1476 0.437030877887048 2123 782427
SGTC_1935 st074532 41.6 µM 0.156508269509211 0.444213004898737 no 1477 0.437816200720958 2138 2829742
SGTC_86 0417-1630 471.922 µM 0.15598562548302 0.444421583944531 no 1478 0.438022175863752 2132 3634867
SGTC_318 1488-0629 67.2 µM 0.155534927248528 0.444601462913823 no 1479 0.43819981050065 2011 3662576
SGTC_1409 3909-8004 61.9 µM 0.155102875957523 0.444773910380618 no 1480 0.43837010746956 2040 2119279
SGTC_1401 3807-4679 7.6 µM 0.153696730065432 0.44533522682127 no 1481 0.43892443158839 2085 3291456
SGTC_237 nikkomycin 200 µM 0.153551328710949 0.445393275556267 no 1482 0.438981757869424 2132 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2978 9011784 42.97 µM 0.153354850717117 0.445471717531176 no 1483 0.439059223779857 2155 2994934
SGTC_2224 6650123 117.647 µM 0.152859674900941 0.445669421240708 no 1484 0.439254468436882 2046 2908370
SGTC_2722 naftopidil 47.16 µM 0.152162851760552 0.445947657457807 no 1485 0.439529246365411 2109 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1195 1502-0147 41.1 µM 0.151807065367281 0.446089730551781 no 1486 0.439669554684407 2067 817940
SGTC_2092 5303694 80.6725 µM 0.151101687402246 0.446371423462866 no 1487 0.439947750715288 2005 1963699
SGTC_1563 conessine 56.1 µM 0.148373246877496 0.447461280605459 no 1488 0.441024106130419 2137 441082 An anti-amoebic, histamine inhibitor.
SGTC_2308 7584454 197.62 µM 0.147066718219074 0.44798330566541 no 1489 0.441539679603232 2112 893577
SGTC_1346 1488-2224 62.4 µM 0.14706549842833 0.447983793076472 no 1490 0.441540160995204 2159 3722427
SGTC_2814 7977482 42.97 µM 0.143627761286553 0.44935777331512 no 1491 0.442897208802931 2117 6456762
SGTC_991 3996-0057 64.7 µM 0.143596629280089 0.449370218823969 no 1492 0.442909501258086 2082 715343
SGTC_2447 5741742 33.78 µM 0.143440595439567 0.449432596554088 no 1493 0.442971111959512 2087 1776504
SGTC_2080 5212524 12.4 µM 0.142827089678347 0.449677870175477 no 1494 0.443213370973093 2186 260183
SGTC_2307 7538926 6.34 µM 0.142048263577885 0.449989264940784 no 1495 0.443520941674101 2033 96582
SGTC_2831 7999036 19.48 µM 0.14088656720288 0.450453798284928 no 1496 0.443979777057993 2152 2988270
SGTC_575 k072-0246 11.9 µM 0.140785510630397 0.450494211500993 no 1497 0.444019694946425 2114 6796779
SGTC_1857 st056007 79.3 µM 0.13846909462043 0.4514207020414 no 1498 0.444934846608701 2166 619834
SGTC_808 0711-0032 135 µM 0.138225699921072 0.451518067404057 no 1499 0.445031022225895 2172 4252555
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.136344892937959 0.45227054593017 no 1500 0.445774317895592 2182 1241132 A phosphatase inhibitor.
SGTC_3082 9117008 49.47 µM 0.134774129561966 0.452899112863477 no 1501 0.446395230403056 2033 41448529
SGTC_973 1325-0077 65.9 µM 0.133471318939363 0.453420543696964 no 1502 0.44691032273597 2121 2835149
SGTC_3215 9129942 49.47 µM 0.133065669416534 0.453582915404397 no 1503 0.447070722745817 2187 17682944
SGTC_2849 9019321 12.99 µM 0.133019564952505 0.45360137039949 no 1504 0.447088953702697 2090 16489627
SGTC_27 0485-0001 32.618 µM 0.132651044255236 0.453748887861911 no 1505 0.447234680807644 2164 2054479
SGTC_1836 st055642 81 µM 0.13234555256089 0.453871179887702 no 1506 0.447355489248125 2017 8571
SGTC_1353 1498-1206 8.11 µM 0.131693907943449 0.454132055722478 no 1507 0.447613202152831 2127 6756808
SGTC_2087 5276107 200 µM 0.131190995009642 0.454333402665719 no 1508 0.447812109665992 2150 144405
SGTC_363 0455-0021 3.06 µM 0.130283092960266 0.45469692131352 no 1509 0.448171227959772 2110 4597466
SGTC_1457 k015-0032 57.3 µM 0.130082239148475 0.454777347136405 no 1510 0.448250680911221 2110 4302660
SGTC_2427 5545055 42.75 µM 0.129596218077437 0.454971967211386 no 1511 0.448442947775188 2088 5372858
SGTC_1028 k015-0029 4.8 µM 0.128189678417463 0.455535256314829 no 1512 0.448999434054365 2178 4588309
SGTC_2939 9044578 71.43 µM 0.127444048103737 0.455833901665271 no 1513 0.449294477549944 2129 2653634
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.127168379910302 0.455944320650282 no 1514 0.449403565667373 2074 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2728 chlorpromazine 9.18 µM 0.127031843850371 0.455999011474293 no 1515 0.449457597480326 2197 2726 A thorazine and dopamine antagonist.
SGTC_1619 st003326 88.7 µM 0.126262828791043 0.456307063349726 no 1516 0.449761939526555 2191 2849032
SGTC_839 0122-0028 230 µM 0.125871314485468 0.456463906161089 no 1517 0.449916894884538 2108 759448
SGTC_3254 9136651 49.47 µM 0.124150474265773 0.457153364442456 no 1518 0.450598067286309 2182 16454030
SGTC_3302 9125395 16.351 µM 0.122743285799608 0.457717253441488 no 1519 0.451155192946654 2090 17599668
SGTC_1295 1013-0063 9.78 µM 0.12273004721362 0.457722558817732 no 1520 0.451160434747271 2200 6826038
SGTC_1503 4585-0012 61.3 µM 0.122684485853509 0.457740817634796 no 1521 0.451178474772649 2146 2922052
SGTC_118 0083-0097 135.343 µM 0.122107462742366 0.457972068643011 no 1522 0.451406955847969 2132 5207356
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.121976922606865 0.458024386613823 no 1523 0.451458647435378 2151 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2382 9035899 200 µM 0.120525192890974 0.458606260721954 no 1524 0.452033562032342 2077 6462679
SGTC_2139 5578692 56.4705 µM 0.119770161164778 0.458908923419719 no 1525 0.452332609848557 2214 650991 YMR113W FOL3
SGTC_1491 4138-0063 26.5 µM 0.118544752635585 0.459400192413517 no 1526 0.452818018790997 2213 23883227
SGTC_2792 7535235 81.82 µM 0.116895590495612 0.460061442903163 no 1527 0.453471396236311 2059 1281891
SGTC_276 colchicine 750 µM 0.116717728483019 0.460132765351176 no 1528 0.453541870501271 2101 2833 A microtubule depolymerizer.
SGTC_359 0081-0058 15.9 µM 0.116488671559112 0.46022461878504 no 1529 0.453632631880859 2177 3494159
SGTC_2621 lithochol-11-enic acid 100 µM 0.11546442672566 0.460635374049006 no 1530 0.454038507605533 2208 6708711
SGTC_340 k038-0059 454 µM 0.113905177347193 0.461260763922983 no 1531 0.45465648067631 2173 23733424
SGTC_471 1-acyl-paf 4 µM 0.113106930355908 0.461580965145044 no 1532 0.454972890312422 2139 16759367
SGTC_776 4476-4378 112 µM 0.112944801449584 0.461646003045445 no 1533 0.455037158565588 2052 2892008
SGTC_810 3825-7150 143 µM 0.111782767841252 0.462112181953224 no 1534 0.455497825575618 2215 22330411 YGL099W LSG1
SGTC_2066 5222451 176 µM 0.111290034001409 0.462309870235824 no 1535 0.455693179013921 2204 2281147
SGTC_2575 plumbagin 510 nM 0.110872508129144 0.462477391842171 no 1536 0.455858723250084 2093 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1276 0871-0068 94.2 µM 0.11010403476018 0.462785739556958 no 1537 0.456163434169675 2181 3414906
SGTC_2990 9074105 71.4286 µM 0.109466245296403 0.463041667722853 no 1538 0.456416346598168 2230 6502001
SGTC_1152 3909-8331 15.9 µM 0.109420492887186 0.463060027552727 no 1539 0.45643449018203 2083 16001939
SGTC_1027 k015-0025 8.67 µM 0.107419448431471 0.463863096366614 no 1540 0.457228113079318 2224 3598955
SGTC_2221 6807166 181.081 µM 0.107300097404559 0.463910999582409 no 1541 0.457275453635976 2208 674925
SGTC_641 4092-0595 30 µM 0.105597008202687 0.464594615089644 no 1542 0.457951049294399 2186 786260
SGTC_2086 5274770 176.623 µM 0.105171601854563 0.464765388467911 no 1543 0.458119822082096 2123 689278
SGTC_31 0508-1974 57.237 µM 0.103948476800201 0.465256430817984 no 1544 0.458605118263 2198 6810525
SGTC_932 2857-0803 154 µM 0.102969883199741 0.465649340394316 no 1545 0.458993436796601 2209 674898
SGTC_370 0180-0345 38.7 µM 0.102248186173506 0.46593912635807 no 1546 0.459279840554998 2146 3989527
SGTC_316 k060-0003 58.6 µM 0.102187949260426 0.465963314351314 no 1547 0.45930374638921 2200 6152314
SGTC_609 0986-0026 86.3 µM 0.101795256930087 0.466121002126617 no 1548 0.459459595257974 2175 2848610
SGTC_3327 9140648 26.9345 µM 0.101013099162643 0.466435097723467 no 1549 0.45977003086862 2199 8029710
SGTC_1840 st055363 71 µM 0.100131308649025 0.466789228476019 no 1550 0.460120039762595 2071 676033
SGTC_2123 5259487 200 µM 0.0997239427389403 0.466952837222427 no 1551 0.460281745867161 2215 2173474
SGTC_2581 avocatin a 64 µM 0.0997117613497002 0.466957729671343 no 1552 0.460286581436891 2145 6710728 A skin care supplement.
SGTC_704 1310-0270 142 µM 0.0982203018187058 0.467556786660585 no 1553 0.460878680944425 2141 5718033
SGTC_272 doxorubicin 8.13 µM 0.0969022187826116 0.468086266767927 no 1554 0.461402023384011 2227 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2107 5363541 170.161 µM 0.0953544594888631 0.468708080908269 no 1555 0.462016643627104 2245 244052
SGTC_2225 6654152 15.4 µM 0.0952712472105345 0.468741513716291 no 1556 0.462049690075848 2219 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1525 8-methoxypsoralen 92.5 µM 0.0952287623547718 0.468758583253739 no 1557 0.462066562369749 2252 4114 Related to psoralen; DNA damaging agent.
SGTC_1570 verbenone 133 µM 0.0947260875141465 0.468960551972132 no 1558 0.462266198152817 2250 29025 A natural terpanoid with antifungal properties.
SGTC_3256 9138902 49.47 µM 0.0944796713786586 0.469059561939019 no 1559 0.462364065046365 2241 17228773
SGTC_833 3852-0053 558 µM 0.0943634775814677 0.469106249253815 no 1560 0.462410213488873 2193 3123681
SGTC_2100 5377183 190 µM 0.0938108495514539 0.469328304077766 no 1561 0.46262970650001 2196 2844202
SGTC_2330 7979373 200 µM 0.0932233169299742 0.469564394589363 no 1562 0.462863075408686 2124 1863007
SGTC_1466 k213-0079 57.5 µM 0.0928511299651451 0.469713957462456 no 1563 0.46301091529224 2198 3657981
SGTC_3046 9092212 49.47 µM 0.091302514349297 0.470336312381678 no 1564 0.463626110086862 2235 25236637
SGTC_1263 0774-1208 64.8 µM 0.091244861803211 0.470359483093976 no 1565 0.463649014518975 2246 906585
SGTC_1883 5-benzylidenerhodanine 20 µM 0.0901487814559782 0.47080001971555 no 1566 0.464084492499985 2264 1273210
SGTC_2959 9079155 11 µM 0.0900576542474293 0.470836647180374 no 1567 0.464120699721852 2167 16189457
SGTC_355 1311-2252 105 µM 0.0900270679567046 0.470848941020448 no 1568 0.464132852521251 2135 5338538
SGTC_1711 st032263 62.8 µM 0.0899451425429962 0.470881870221587 no 1569 0.464165403972776 2157 3958979
SGTC_457 grayanotoxin iii 135 µM 0.0877178363172375 0.471777191947828 no 1570 0.465050471468738 2176 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2268 7933382 153.85 µM 0.0875095125105919 0.471860940303236 no 1571 0.465133262274934 2264 935025 YOR257W CDC31
SGTC_1128 3448-9350 235 µM 0.0870454020504178 0.472047522044485 no 1572 0.465317711710736 2079 619386
SGTC_1864 st057645 30.4 µM 0.0869907100368477 0.472069509738985 no 1573 0.46533944821541 2269 688666
SGTC_924 2046-0044 21.3 µM 0.0864540740943297 0.472285256660054 no 1574 0.465552731442259 2271 3623589
SGTC_2942 9052777 62.25 µM 0.0851818524361134 0.472796767832453 no 1575 0.466058408897987 2208 6469503
SGTC_342 k048-0088 23.3 µM 0.082357231126547 0.473932598079967 no 1576 0.467181322541229 2236 6820570
SGTC_1504 k297-0033 30 µM 0.0822656538489848 0.473969426521792 no 1577 0.467217733036293 2219 4388117
SGTC_1824 st053723 68.6 µM 0.0807389190356644 0.474583446120293 no 1578 0.467824792460193 2161 675225
SGTC_2250 alverine citrate 130 µM 0.0786214670425676 0.475435138973786 no 1579 0.468666856079998 2235 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_601 0986-0029 62.9 µM 0.0785476990605403 0.475464812371698 no 1580 0.468696194516661 2215 24747981
SGTC_247 mechlorethamine 29.705 µM 0.0776739069076528 0.475816308263213 no 1581 0.469043725326484 2204 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2899 9053889 58.44 µM 0.0775905396912126 0.475849844953925 no 1582 0.469076883963604 2286 6470052
SGTC_1015 4130-4525 82 µM 0.0763675050605147 0.476341862859522 no 1583 0.469563360646094 2096 1363237
SGTC_1805 st050013 60.3 µM 0.0761664185687752 0.476422761960466 no 1584 0.46964334957713 2227 4037144
SGTC_227 fluconazole 33.516 µM 0.0761360476606485 0.47643498056423 no 1585 0.469655430736259 2161 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2378 9074213 121.43 µM 0.076087917881874 0.476454343833569 no 1586 0.469674576204393 2256 657714
SGTC_2696 st077691 74.316 µM 0.0752525429065522 0.476790435447561 no 1587 0.470006889817982 2224 757133
SGTC_1464 k208-0027 110 µM 0.0741488509886375 0.477234502753232 no 1588 0.470445972372766 2256 X1464
SGTC_1746 st038117 42 µM 0.0728090429707199 0.477773608636566 no 1589 0.470979037404269 2195 2898218
SGTC_2902 5787006 60.46 µM 0.0726002660033616 0.477857619055216 no 1590 0.471062107520242 2230 591003
SGTC_1627 st003713 25.6 µM 0.0717030468147795 0.47821866505189 no 1591 0.47141911569938 2198 16195070 YER133W GLC7
SGTC_2319 6033012 152.6 µM 0.0713611611521458 0.478356246465675 no 1592 0.471555159840806 2226 847246
SGTC_1210 3013-0140 750 nM 0.0708002414026109 0.478581977018898 no 1593 0.471778369848544 2292 905973
SGTC_2714 st079313 56.9 µM 0.0699058630104321 0.478941915288395 no 1594 0.472134293270465 2238 2939799
SGTC_897 1000-0139 31.4 µM 0.0696142282916131 0.479059286001505 no 1595 0.472250355938568 2274 6151020
SGTC_3164 9100705 49.47 µM 0.0695052308408247 0.479103153359581 no 1596 0.472293734558135 2280 17174235
SGTC_2291 7917025 104.35 µM 0.0694115034125599 0.479140875312645 no 1597 0.472331036302998 2234 2964612
SGTC_506 n9-isopropylolomoucine 153 µM 0.0660146936080089 0.480508093738007 no 1598 0.473683063582755 2309 6610355
SGTC_2223 6903751 107.57 µM 0.0657086108651913 0.480631303768377 no 1599 0.473804908376336 2262 5598863
SGTC_2764 methyldopa 94.69 µM 0.0656848171541521 0.480640881726298 no 1600 0.473814380231067 2285 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_1138 3761-0006 1.03 µM 0.0641188785653685 0.481271261422103 no 1601 0.474437784927305 2283 12061087
SGTC_1693 xanthone 101.9 µM 0.064096816411148 0.48128014303717 no 1602 0.474446568385663 2220 7020 An insecticide.
SGTC_1478 0453-0656 35.7 µM 0.0640038665668107 0.481317562183994 no 1603 0.474483574023788 2285 5258496
SGTC_275 trichlorophene 5.69 µM 0.0634341774606311 0.48154690752147 no 1604 0.474710386182604 2223 62616
SGTC_1284 0929-0043 16 µM 0.0632149074407058 0.481635182838383 no 1605 0.474797687050471 2208 1239883
SGTC_1777 st045864 34.765 µM 0.062977459845272 0.481730777231037 no 1606 0.474892226561059 2299 4691462
SGTC_3269 9137823 49.47 µM 0.0627412694318685 0.48182586653498 no 1607 0.474986266928484 2205 17682936
SGTC_1578 josamycin 24.2 µM 0.0616995558036359 0.482245268486413 no 1608 0.475401046857261 2137 5282165 A P450 substrate.
SGTC_948 3448-0295 75.3 µM 0.0613510592081192 0.482385580316343 no 1609 0.47553981399236 2306 678569
SGTC_2857 9024691 58.44 µM 0.0600243767192719 0.482919749531001 no 1610 0.4760681099381 2248 16478292
SGTC_451 chloral hydrate 100 µM 0.0598880301623979 0.48297464922286 no 1611 0.476122406665146 2219 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.0595429334201134 0.483113603235361 no 1612 0.476259835096535 2149 688788
SGTC_3124 9127567 49.47 µM 0.0586013540215445 0.483492742771463 no 1613 0.476634816092565 2303 17592030
SGTC_1733 st037357 54.9 µM 0.0578942702651055 0.483777469333682 no 1614 0.476916423567511 2310 1272339 YGL099W LSG1
SGTC_2364 9055074 200 µM 0.0576982683905064 0.483856396305588 no 1615 0.476994486512188 2241 6470630
SGTC_1680 diphenhydramine 100 µM 0.0575704617689823 0.483907862427874 no 1616 0.477045389364437 2159 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2406 ethylparaben 405.7 µM 0.0572836423545375 0.484023361980656 no 1617 0.47715962523261 2107 8434 A possible steroid mimic.
SGTC_2655 perillic acid 100 µM 0.0569037504721892 0.484176343026405 no 1618 0.477310933355675 2243 5702197 An apoptosis inducer.
SGTC_2785 7756463 72.73 µM 0.0560030252059182 0.484539071003065 no 1619 0.477669698589864 2285 2201551
SGTC_1766 st045414 44.774 µM 0.0555164880276705 0.484735008059424 no 1620 0.477863497330326 2310 253960
SGTC_885 0865-0106 16.8 µM 0.0552559049635609 0.484839950949126 no 1621 0.477967295602317 2284 2793380
SGTC_82 0054-0107 293.755 µM 0.0550103280345005 0.484938851478766 no 1622 0.478065117835937 2315 3104697
SGTC_3161 9100388 49.47 µM 0.0536468636742608 0.48548797246181 no 1623 0.478608259216229 2267 25236368
SGTC_2303 7774051 200 µM 0.053420870475121 0.485578991541224 no 1624 0.478698288359653 2291 2953184
SGTC_1126 isoteolin 1.0172 µM 0.053199792886727 0.485668031578496 no 1625 0.478786360317896 2312 133323
SGTC_1705 st027868 56.3335 µM 0.0530755698547242 0.485718063302032 no 1626 0.478835848220839 2306 292948
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.0527943444256621 0.485831329704547 no 1627 0.478947883856366 2317 5024745
SGTC_1318 1280-3875 124 µM 0.052201062024434 0.486070283965583 no 1628 0.479184243358019 2273 373245
SGTC_2639 lactacystin 53 µM 0.0516447922524641 0.486294335325385 no 1629 0.479405863941592 2274 3870 A proteasome inhibitor.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.0507499334371248 0.486654770814657 no 1630 0.479762393377689 2331 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1505 k297-0037 20.6 µM 0.0496459824382617 0.487099440436766 no 1631 0.480202251550055 2278 4089396
SGTC_2474 5321570 43.32 µM 0.0483881656868674 0.487606106444429 no 1632 0.480703445335849 2292 2841384
SGTC_3141 9094609 49.47 µM 0.0481822394571025 0.487689058309102 no 1633 0.480785502303323 2257 25236309 YDL196W YDL196W
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.0465918247716002 0.488329731926511 no 1634 0.481419273921557 2305 279621
SGTC_2713 st079149 53.4 µM 0.0460297328112082 0.488556169146838 no 1635 0.481643275831117 2268 3103253
SGTC_1545 lovastatin 49.4 µM 0.045323172461272 0.488840810289701 no 1636 0.48192485873065 2301 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1373 2887-0003 58.5 µM 0.0451062065173385 0.488928217182742 no 1637 0.482011327187055 2276 776948
SGTC_2586 curcumin 80 µM 0.044647663351689 0.489112947611752 no 1638 0.48219407532711 2307 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_534 k292-0788 63.4 µM 0.0437242134904602 0.489484979152703 no 1639 0.48256211904834 2339 4146317
SGTC_3189 9110682 49.47 µM 0.043251344968679 0.489675487919602 no 1640 0.482750587993705 2294 17122418
SGTC_2429 5902844 64.44 µM 0.0416056677663274 0.490338514683068 no 1641 0.483406527465922 2321 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_3092 9117248 49.47 µM 0.0412938135070033 0.49046416068671 no 1642 0.483530832485861 2343 17141857
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.0409273603609092 0.490611805776596 no 1643 0.48367690265148 2259 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1843 st055809 45.5 µM 0.0389475423495514 0.491409502225065 no 1644 0.484466105994212 2262 16413835
SGTC_910 3454-3003 490 µM 0.0386474761255773 0.491530406192876 no 1645 0.484585725035455 2342 820824
SGTC_2589 lobaric acid 100 µM 0.0384304129802965 0.491617866690489 no 1646 0.48467225641721 2304 73157 A novel microtubule depolymerizer.
SGTC_1971 st069429 63.5 µM 0.0377183600042406 0.491904774524542 no 1647 0.484956118622979 2343 1246522 YGL099W LSG1
SGTC_881 0833-0569 170 µM 0.0371935444606823 0.492116241382875 no 1648 0.485165342913391 2293 5418700
SGTC_902 1120-0002 2.07 µM 0.0367349457890791 0.492301028923199 no 1649 0.485348172363948 2325 3280475
SGTC_399 oxolinic acid 75 µM 0.0338122366541253 0.493478741164394 no 1650 0.486513439043477 2294 4628 A DNA gyrase inhibitor.
SGTC_2806 7952793 58.44 µM 0.0337060324842044 0.493521537506726 no 1651 0.486555784240348 2315 2972490
SGTC_236 1509-0011 5.31 µM 0.0336041039835197 0.493562610983031 no 1652 0.486596424806267 2339 3107280
SGTC_3319 9138450 16.7555 µM 0.0304021402125527 0.494852918353211 no 1653 0.487873169001657 2263 2029690
SGTC_493 zm226600 134 µM 0.0301366180670513 0.494959919412944 no 1654 0.487979048495192 2339 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1186 1319-0216 26 µM 0.0300792034083492 0.49498305662451 no 1655 0.488001943250817 2352 4565136
SGTC_3127 9126946 49.47 µM 0.0299000341019732 0.4950552591674 no 1656 0.488073389326673 2262 27243249
SGTC_1174 0739-0097 51.1 µM 0.0295890756873126 0.495180571127214 no 1657 0.488197388919484 2329 728447
SGTC_2872 9044037 25.97 µM 0.0293537583634306 0.495275401085649 no 1658 0.488291226188368 2303 6465195
SGTC_3347 9188721 44.724 µM 0.0276877444679443 0.495946791316057 no 1659 0.488955599227689 2317 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1616 st002734 56.1 µM 0.0272889245903572 0.496107514300888 no 1660 0.489114645238455 2281 4026101
SGTC_1038 k292-0204 154 µM 0.0260420644651474 0.496609998429798 no 1661 0.48961189361264 2354 4454212
SGTC_2796 7949634 45.45 µM 0.0253908926020728 0.496872422617028 no 1662 0.48987158770915 2360 2971588
SGTC_1079 idarubicin 2.36 µM 0.025157203056585 0.496966600531114 no 1663 0.489964786577697 2362 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2040 5100729 123 µM 0.0247634583676137 0.497125281751269 no 1664 0.490121819056139 2347 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2452 5863136 48.41 µM 0.0243564706114835 0.497289300476204 no 1665 0.490284134717419 2360 2184096
SGTC_142 0335-0849 62.6745 µM 0.023909630493281 0.49746938049011 no 1666 0.490462346228551 2361 3889043 YPR107C YTH1
SGTC_1488 4013-0813 75.9 µM 0.0236479895769411 0.497574824039022 no 1667 0.490566696346456 2351 2910057
SGTC_3244 9134489 49.47 µM 0.0234167146252891 0.49766802998322 no 1668 0.490658936159432 2321 16584271
SGTC_2207 7258803 200 µM 0.0230062037762746 0.497833469961771 no 1669 0.490822662181092 2359 3666799
SGTC_2317 5986382 200 µM 0.0229541206305861 0.497854460017706 no 1670 0.490843434864376 2350 877883
SGTC_154 3389-1638 511.116 µM 0.0220399493511978 0.498222881580623 no 1671 0.491208044147482 2301 5238686
SGTC_277 nystatin 15.5 µM 0.0216016932736951 0.498399504388278 no 1672 0.491382841405384 2372 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_869 0564-0080 44.1 µM 0.0213164031233413 0.498514480140508 no 1673 0.491496629505957 2302 6843321
SGTC_3001 9076041 71.4286 µM 0.0205073610447435 0.498840535575124 no 1674 0.491819320023839 2370 16004211
SGTC_1797 st048695 56.8 µM 0.0194850247124217 0.499252552700078 no 1675 0.492227091662407 2372 592262 YIL048W NEO1
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.0190941955175555 0.499410063057404 no 1676 0.492382980946616 2376 77254
SGTC_3119 9125183 49.47 µM 0.0187485243725348 0.499549374082641 no 1677 0.492520859097163 2370 22695334
SGTC_640 3381-0960 37.1 µM 0.0186031833927526 0.499607948850032 no 1678 0.49257883164809 2359 1745025
SGTC_2273 7815444 169.05 µM 0.0166575990348408 0.499607948850032 no 1679 0.493354886765919 2373 2824616
SGTC_3135 9127742 49.47 µM 0.0162920208387396 0.499460614938556 no 1680 0.493500711573144 2334 3643468
SGTC_2913 7966556 36.57 µM 0.016040622963551 0.499359297580134 no 1681 0.493600991709534 2374 2976516
SGTC_1978 st071761 42 µM 0.0155858371181133 0.499176011731154 no 1682 0.493782402327216 2332 5147680
SGTC_159 3970-0959 50 µM 0.015375806706603 0.499091366228139 no 1683 0.493866182298602 2370 6615653
SGTC_2023 5144124 124 µM 0.0152585075031384 0.499044092853195 no 1684 0.493912972421133 2365 2830192
SGTC_2210 7115885 190.385 µM 0.0144756545312606 0.498728591495277 no 1685 0.494225251049585 2381 2927039
SGTC_3083 9117465 49.47 µM 0.0136163093428191 0.498382263562579 no 1686 0.494568046351524 2317 16420915
SGTC_2168 5727979 200 µM 0.0133665703009087 0.498281615510169 no 1687 0.494667668747155 2377 695210
SGTC_1331 1472-0049 76.2 µM 0.013241864593216 0.498231357543364 no 1688 0.494717414723761 2382 24051409
SGTC_2013 4024628 200 µM 0.0124559800103746 0.497914636862124 no 1689 0.495030911423898 2373 5230760
SGTC_2932 9016711 44.54 µM 0.0115264677204591 0.49754003424693 no 1690 0.495401706503982 2380 7117328
SGTC_1298 1079-1278 263 µM 0.0111861614249411 0.497402887980341 no 1691 0.495537460318809 2395 2840950
SGTC_637 1181-0519 7.26 µM 0.0110491809671209 0.497347683802637 no 1692 0.495592104237809 2383 6252091 YGR060W ERG25
SGTC_3114 9122766 49.47 µM 0.00947410538168857 0.496712920146724 no 1693 0.496220435335802 2361 17176985
SGTC_883 0850-0245 24.6 µM 0.00778916550986947 0.496033889866114 no 1694 0.496892603970622 2373 6823229 YPR165W RHO1
SGTC_2468 5987765 72.9 µM 0.00621643676486971 0.495400090965996 no 1695 0.497520016513844 2366 26772094
SGTC_1043 0916-0009 19.3 µM 0.00567298278003985 0.495181085354656 no 1696 0.497736819452282 2396 3101130
SGTC_2464 5717415 7.67 µM 0.00553829141092954 0.495126806527386 no 1697 0.497790552689944 2398 5285744
SGTC_1486 3970-0793 4.53 µM 0.00421315448530075 0.494592798968919 no 1698 0.498319199514508 2398 2844330
SGTC_1201 1889-3372 45.9 µM 0.00367618774459262 0.494376413244055 no 1699 0.498533416581311 2383 5392199
SGTC_1862 st057513 3.81 µM 0.00258609841372913 0.493937136500553 no 1700 0.498968297151473 2401 5393163
SGTC_2566 crystal violet carbinol 226 nM 0.00252084632820653 0.493910841889298 no 1701 0.498994328882401 2390 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1524 corynanthine 62.1 µM 0.00231122610329796 0.493826371476393 no 1702 0.499077955008718 2376 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2411 st077133 39.94 µM 0.00128859322932587 0.493414286362096 no 1703 0.499485925820851 2401 1403142 YNL221C POP1
SGTC_1018 4259-0013 28.1 µM 0.00113585110309893 0.49335273724492 no 1704 0.49954686106817 2389 6801262
SGTC_1226 3909-7979 35.4 µM 0.00103612691799172 0.493312552374658 no 1705 0.499586645238511 2402 6615510
SGTC_1280 0880-0253 10.1 µM 0.00095753196792496 0.493280881791423 no 1706 0.499618000071533 2402 6836607
SGTC_15 0266-0086 27.098 µM 0.000403581911123686 0.493057663555918 no 1707 0.499838994116418 2404 1712902 YIL048W NEO1
SGTC_2368 9071271 200 µM 0.000207150879300704 0.492978510750409 no 1708 0.499917358756416 2405 27209959
SGTC_303 1348-1668 34.2 µM 0 0.492895038631647 no 1709 0.5 2405 5380509
SGTC_3072 9116419 49.47 µM -4.77008354709223e-05 0.492875817469199 no 1710 0.499980970119927 2406 17170162
SGTC_1708 st033234 31.827 µM -0.00023709186942666 0.492799502075818 no 1711 0.499905414029832 2408 674664
SGTC_1163 k060-0048 49.9 µM -0.000758869295289357 0.492589252472674 no 1712 0.499697254981868 2405 6809982
SGTC_462 ag-879 158 µM -0.0025511914303212 0.491867054408997 no 1713 0.498982222977094 2411 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_514 4466-0038 2.65 nM -0.00297185198695237 0.491697557270574 no 1714 0.498814404336488 2426 5722064
SGTC_2252 omeprazole 400 µM -0.00397803551800047 0.491292140969496 no 1715 0.498412997624589 2431 4594 A proton pump inhibitor.
SGTC_3056 9094900 49.47 µM -0.0048947936514343 0.490922764200086 no 1716 0.498047267656193 2421 25236784
SGTC_958 1222-0007 33 µM -0.00686614610926759 0.490128500994782 no 1717 0.497260825536206 2422 7312461
SGTC_2167 5876490 200 µM -0.00700301785747866 0.490073356416373 no 1718 0.497206222921787 2432 686534
SGTC_1728 st035614 33.7865 µM -0.0072926841157021 0.489956652727842 no 1719 0.497090665756628 2463 15945546
SGTC_2985 9022375 71.43 µM -0.00731576518995669 0.489947353626724 no 1720 0.49708145798586 2483 4939335
SGTC_1502 4534-4282 27.7 µM -0.00881645612550351 0.489342754352704 no 1721 0.496482788453708 2431 3278949
SGTC_1909 st060837 51.5 µM -0.00896716321790335 0.48928203871801 no 1722 0.496422667399411 2433 678937
SGTC_343 4130-2827 29.8 µM -0.00918491410947038 0.489194313467606 no 1723 0.496335800940204 2438 1118244
SGTC_2416 tofa 880 nM -0.0107485962054055 0.488564368841922 no 1724 0.495712013085707 2437 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_416 estradiol valerate 100 µM -0.0113385217246273 0.488326718903531 no 1725 0.495476681208212 2439 13791 A steroid.
SGTC_1225 1216-0074 20.6 µM -0.0113520229651473 0.488321280012615 no 1726 0.495471295339163 2443 4241466
SGTC_1162 k048-0130 20.1 µM -0.0118097958534041 0.488136870338626 no 1727 0.495288682626998 2428 6797406
SGTC_862 0452-0056 10.2 µM -0.0120138203909656 0.488054681710921 no 1728 0.495207294387208 2436 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_2865 9030313 51.95 µM -0.0120959470003822 0.488021598218954 no 1729 0.495174532990908 2420 42562754
SGTC_545 4218-0007 221 µM -0.0130904200416201 0.487620996046996 no 1730 0.494777827122081 2441 2840508
SGTC_1024 4507-0395 26 µM -0.0141668980139452 0.48718737403408 no 1731 0.494348414447213 2503 4201836
SGTC_1111 tnp00062 510.699 nM -0.0143572946970333 0.487110680860748 no 1732 0.494272464885139 2432 676306
SGTC_802 4112-3352 742 µM -0.0146880344076546 0.48697745762667 no 1733 0.494140532744857 2511 704594
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.0152600129337319 0.48674706590342 no 1734 0.493912371911136 2435 2724278 An inhibitor of dopamine biosynthesis.
SGTC_505 gw-5074 63.9 µM -0.0153452113998177 0.486712748520686 no 1735 0.493878386620199 2487 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3287 9117173 37.0625 µM -0.0172979286196171 0.485926234325379 no 1736 0.493099469039548 2431 2789709
SGTC_1785 bathophenanthroline 24 µM -0.018216758876905 0.485556167214069 no 1737 0.492732966602221 2447 72812 An iron chelator.
SGTC_1476 4112-3294 3.34 µM -0.0191411168749667 0.485183886307885 no 1738 0.492364265453718 2480 704369
SGTC_335 4077-0256 27.6 µM -0.0199071928896927 0.484875362509886 no 1739 0.492058703593427 2481 3121989
SGTC_2753 fluvastatin 17.09 µM -0.020490633604185 0.484640397968027 no 1740 0.491825991905182 2466 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2153 5569715 200 µM -0.022757403085754 0.483727570876885 no 1741 0.490921893314711 2448 2054701
SGTC_2367 9070478 135.38 µM -0.0231555770923828 0.483567235046587 no 1742 0.490763086720645 2454 572802
SGTC_701 4424-0219 185 µM -0.026312295339821 0.482296190867452 no 1743 0.48950412402219 2451 2911779
SGTC_1094 duloxetine 25.4 µM -0.0272702196811396 0.481910520177889 no 1744 0.489122104641526 2447 60834 A selective serotonin reuptake inhibitor.
SGTC_598 3937-0236 20.2 µM -0.0275428028921374 0.481800778310253 no 1745 0.489013400506489 2472 1379313
SGTC_964 1287-0107 19.4 µM -0.0278207569239201 0.481688875572906 no 1746 0.488902555368955 2465 51516812 YPR165W RHO1
SGTC_2025 5147754 141 µM -0.0280101404371457 0.481612631656398 no 1747 0.488827031710911 2473 315777 YLR208W SEC13
SGTC_1896 st058441 89 µM -0.0282725093358674 0.481507005662352 no 1748 0.488722403102137 2476 688759
SGTC_781 4335-2806 94.4 µM -0.029411724566432 0.481048388934676 no 1749 0.488268110999511 2552 845254
SGTC_1136 pergolide 1.05886 µM -0.0299494482348036 0.480831924847585 no 1750 0.488053684764435 2468 47811 A dopamine receptor agonist.
SGTC_972 1319-0219 195 µM -0.0309422330745691 0.480432287885341 no 1751 0.487657804455758 2482 23903702
SGTC_984 1492-0255 2.91 µM -0.0311847294149323 0.480334676051227 no 1752 0.48756110907685 2502 1585198
SGTC_2635 hydroquinidine 100 µM -0.0315259999216821 0.480197306739445 no 1753 0.487425028754048 2475 442912 An experimental heart treatment.
SGTC_1493 4348-0038 111 µM -0.0330097801737402 0.479600078249426 no 1754 0.486833394220998 2468 800424
SGTC_1887 st057648 70.8 µM -0.0334055837656001 0.479440773134793 no 1755 0.486675578474162 2461 688672
SGTC_2165 5727197 32.143 µM -0.0335015381293426 0.479402153410624 no 1756 0.486637319635994 2646 1361712
SGTC_689 0833-0039 98 µM -0.0335901988516155 0.479366469404047 no 1757 0.486601969021348 2491 5374726
SGTC_255 tunicamycin 200.472 nM -0.0340197971825871 0.479193567794745 no 1758 0.486430681984336 2471 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2926 9010726 65.15 µM -0.0341320362487644 0.479148395276112 no 1759 0.486385931064562 2511 2994293
SGTC_210 3551-0445 56.827 µM -0.0342207530769461 0.479112689871188 no 1760 0.486350558834704 2507 2865180 YOR207C RET1
SGTC_866 0495-0101 262 µM -0.0354229347466473 0.478628870649126 no 1761 0.485871248451385 2488 635694
SGTC_857 0438-0306 1.35 µM -0.0355950714399421 0.478559596624467 no 1762 0.485802619127138 2518 4686136
SGTC_73 0327-0325 16.231 µM -0.0367347258587728 0.478100974949309 no 1763 0.485348260044266 2519 53298
SGTC_366 0181-0206 4.31 µM -0.0368744437420234 0.478044751423624 no 1764 0.48529255841222 2479 274874
SGTC_2060 5238662 140 µM -0.0368747939074017 0.478044610514995 no 1765 0.485292418811388 2512 790130
SGTC_422 cantharidin 155 µM -0.0372182134322735 0.477906417780571 no 1766 0.485155508226933 2460 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_888 0916-0002 6.97 µM -0.0396624520962878 0.476922928747427 no 1767 0.484181118496817 2610 2802138 YIL048W NEO1
SGTC_2280 7785178 200 µM -0.0413094434502638 0.476260307240148 no 1768 0.483524602356675 2495 2954328
SGTC_2859 9028643 45.46 µM -0.0432692735719854 0.475471909367467 no 1769 0.482743442205455 2539 17151580
SGTC_2602 kawain 100 µM -0.0442595100729765 0.475073594658625 no 1770 0.482348773153916 2472 5369129
SGTC_1064 honokiol 6.76 µM -0.0444078521958872 0.47501392736244 no 1771 0.482289651338968 2524 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_3199 9111318 49.47 µM -0.0454741976714582 0.474585030353803 no 1772 0.481864670446177 2527 8548020
SGTC_699 0375-0592 111 µM -0.0467897275661517 0.474055949000622 no 1773 0.481340408141225 2480 762578
SGTC_1970 st070122 35.8 µM -0.0481397663291842 0.473513036411318 no 1774 0.480802426990188 2548 102928
SGTC_622 1348-1566 26.3 µM -0.0481615289962617 0.473504285043595 no 1775 0.480793755000924 2539 7340407
SGTC_2706 st078239 82.5 µM -0.0484990752009317 0.473368550059421 no 1776 0.480659250729454 2485 15434492
SGTC_1853 st056710 91.2 µM -0.0485297116970475 0.47335623058234 no 1777 0.480647042910732 2564 269167
SGTC_3211 9128781 49.47 µM -0.0492191974802636 0.473078982913691 no 1778 0.480372306215002 2598 17194361
SGTC_1397 3532-0190 20.1 µM -0.0503127428982756 0.472639286478066 no 1779 0.479936584633436 2485 5322280
SGTC_282 k297-0036 65.7 µM -0.0507436738377972 0.472466025437939 no 1780 0.479764887383122 2539 5061378
SGTC_1248 0469-0687 58.6 µM -0.0508279828149789 0.472432128593691 no 1781 0.479731296314509 2539 4017482
SGTC_971 1315-0384 26.7 µM -0.0516324486449949 0.472108699176114 no 1782 0.479410781767324 2525 6769120
SGTC_2863 9028737 58.44 µM -0.0526364892376344 0.471705058055999 no 1783 0.479010771524504 2555 6460917
SGTC_269 exalamide 29 µM -0.0538951564052776 0.471199093891142 no 1784 0.478509347843863 2527 3316 A derivative of salicylamide.
SGTC_3198 9112019 49.47 µM -0.0539020759559717 0.471196312469643 no 1785 0.478506591349331 2522 45595555
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.054123514998256 0.471107302329918 no 1786 0.478418378721875 2668 5282309
SGTC_1328 1441-0025 69.2 µM -0.0546573668094307 0.470892719987671 no 1787 0.478205717458249 2500 4562601
SGTC_2572 astragaloside iv 100 µM -0.0547078842608719 0.470872414877356 no 1788 0.478185594019923 2640 45006101 An anti-inflammatory agent.
SGTC_3273 9137859 49.47 µM -0.0548261806372752 0.470824866833419 no 1789 0.478138471317377 2493 2377234
SGTC_1877 wortmannin 25 µM -0.0554941125501189 0.470556406112931 no 1790 0.477872410114362 2511 312145 A covalent inhibitor of PI 3-kinase.
SGTC_871 0574-0004 149 µM -0.0562413838423443 0.47025607251801 no 1791 0.477574756888941 2528 9551173
SGTC_919 tnp00227 403.569 nM -0.0568068751340108 0.470028808822338 no 1792 0.477349518609632 2546 1269246 A methoxyflavone. YNL221C POP1
SGTC_995 3931-2021 34.6 µM -0.0572745327826908 0.469840870584666 no 1793 0.477163253469162 2564 730143
SGTC_3200 9114385 49.47 µM -0.0585566017201984 0.469325678316063 no 1794 0.47665263907172 2562 17018030 YLR208W SEC13
SGTC_418 lividomycin a 100 µM -0.0592240201399259 0.469057500208564 no 1795 0.476386838956675 2512 72394 An antibiotic.
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.0593087955655837 0.469023437252539 no 1796 0.476353077800299 2535 1273210
SGTC_595 3909-8003 73.7 µM -0.0627537020256968 0.467639460699162 no 1797 0.474981316795697 2566 699517
SGTC_349 k015-0014 24 µM -0.063128588073313 0.467488875115414 no 1798 0.474832054851997 2519 2196908
SGTC_3012 9080433 71.4286 µM -0.0653248750845353 0.466606756774189 no 1799 0.473957668593419 2517 17688859
SGTC_2793 7325131 81.82 µM -0.0654065969779533 0.466573937070396 no 1800 0.473925135850193 2582 4176441
SGTC_3263 9137018 49.47 µM -0.0665847808027738 0.466100801056183 no 1801 0.473456131007481 2527 43844957
SGTC_3005 9076496 71.4286 µM -0.0680570668614109 0.465509626643298 no 1802 0.472870103378313 2534 21368410
SGTC_1679 SEC14.276 6.7 µM -0.0701150729117729 0.464683392975407 no 1803 0.472051034889771 2593 1005053 YMR079W SEC14
SGTC_1647 st011722 22.4 µM -0.0709871919691806 0.464333306528665 no 1804 0.471703974550774 2582 2854783
SGTC_2362 9071156 126 µM -0.072113932823847 0.463881050597175 no 1805 0.471255619152491 2595 653133
SGTC_1176 0848-0131 83.3 µM -0.0721245135862639 0.463876803867008 no 1806 0.471251409002133 2589 6769040
SGTC_934 2950-0684 338 µM -0.0724414436786324 0.46374960165604 no 1807 0.471125302063175 2633 1121253
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0726372089816078 0.463671031670229 no 1808 0.471047408213656 2614 165506
SGTC_2208 7283366 200 µM -0.0732373910977911 0.46343015870518 no 1809 0.470808606235999 2539 898663
SGTC_2445 5742597 35.57 µM -0.0732466336736239 0.463426449457913 no 1810 0.470804928858408 2554 1774255
SGTC_83 0170-0301 39.027 µM -0.0737898087872133 0.463208467032771 no 1811 0.470588818163922 2530 3089716
SGTC_1735 st034310 56.75 µM -0.0789037909820959 0.461156717644403 no 1812 0.468554573938851 2769 871153
SGTC_1749 st037932 54.2 µM -0.0792155849909469 0.461031657560255 no 1813 0.468430574258553 2643 594497
SGTC_161 4065-0411 162.148 µM -0.0794240829923611 0.460948031490827 no 1814 0.468347656844369 2622 1906281 YLR208W SEC13
SGTC_2081 5214970 32.255 µM -0.0797743884323126 0.460807532033929 no 1815 0.468208347229376 2542 2063512
SGTC_180 1486-1293 102.781 µM -0.0801467032051211 0.460658210503218 no 1816 0.46806028920159 2570 4140536
SGTC_982 1491-0518 27.5 µM -0.0802979112554486 0.460597568192237 no 1817 0.468000159714092 2604 3091256
SGTC_3031 9088762 49.47 µM -0.0817577771888937 0.460012133188355 no 1818 0.467419666270367 2539 205253
SGTC_365 0121-0052 13.6 µM -0.0830843506367321 0.45948022623425 no 1819 0.466892234601233 2618 3101739
SGTC_1140 3229-1848 2.98 µM -0.0847388516654695 0.458816934167279 no 1820 0.466234503935931 2557 2849525
SGTC_2650 prasterone 100 µM -0.0848172962867779 0.458785488427168 no 1821 0.466203321321167 2549 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_3054 9094397 49.47 µM -0.0856704285718143 0.458443513847378 no 1822 0.465864205129742 2585 2598354
SGTC_634 1611-4317 11.2 µM -0.0864736686997719 0.458121566439758 no 1823 0.465544943491521 2550 2843522
SGTC_3218 9131285 49.47 µM -0.0867678739921762 0.458003652611467 no 1824 0.465428012063073 2584 17156417
SGTC_2910 7948405 25.97 µM -0.0880921432269238 0.457472947852524 no 1825 0.464901720450095 2603 2971328
SGTC_799 1310-0557 151 µM -0.0889865812773132 0.457114542037279 no 1826 0.464546287199773 2691 5354492
SGTC_203 k066-0004 30.888 µM -0.0902360339429782 0.456613938539463 no 1827 0.464049825085003 2533 6795412
SGTC_52 0329-0193 875 nM -0.0906541448298627 0.456446434305559 no 1828 0.463883703829018 2772 3739292
SGTC_2656 pseudo-anisatin 100 µM -0.0908853295779407 0.456353820032945 no 1829 0.463791853622683 2573 6708809 A neurotoxin.
SGTC_3227 9130768 49.47 µM -0.092558929744597 0.455683434793142 no 1830 0.463126986470207 2583 17720899
SGTC_2313 7726885 200 µM -0.0930451978894738 0.455488676481295 no 1831 0.462933827108662 2654 726423
SGTC_2974 9094440 9.66 µM -0.0939171619550902 0.455139467489353 no 1832 0.462587480413058 2790 25236134
SGTC_3318 9139014 38.6185 µM -0.0940523476867849 0.455085330656504 no 1833 0.46253378677502 2563 16643984
SGTC_3296 9122258 64.045 µM -0.0954158335102104 0.454539352347967 no 1834 0.461992270066962 2654 4730474
SGTC_846 0335-0850 148 µM -0.0963515054900974 0.454164732433126 no 1835 0.461620702933197 2579 6819598
SGTC_1579 chlormadinone acetate 49.4 µM -0.0968641110724668 0.453959515103883 no 1836 0.461417154978688 2674 45114258 A steroidal progestin.
SGTC_3268 9137683 49.47 µM -0.0968759560152766 0.453954773225833 no 1837 0.461412451649601 2550 1953228
SGTC_2846 9008642 19.48 µM -0.0978033857693108 0.453583516320788 no 1838 0.46104420941042 2703 2992898
SGTC_2652 actinonin 100 µM -0.0984637276007978 0.453319201363667 no 1839 0.460782036570983 2567 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2935 9038016 29.96 µM -0.0994274089784558 0.45293350585737 no 1840 0.460399460682592 2605 6463195
SGTC_2811 7967822 32.47 µM -0.10089462694415 0.452346364598871 no 1841 0.459817054210538 2677 2232244
SGTC_2675 theaflavin digallate 100 µM -0.101229675371371 0.452212301776201 no 1842 0.459684070085137 2607 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_2742 clothiapine 36.27 µM -0.10131140246748 0.452179601164742 no 1843 0.459651632453921 2572 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_702 1488-0190 94 µM -0.101524765250831 0.452094232066744 no 1844 0.459566949648435 2632 949357
SGTC_2304 7443016 91.4 µM -0.101761985690901 0.451999319824558 no 1845 0.459472799991404 2567 939854
SGTC_1400 3771-8998 51.5 µM -0.102883052355899 0.451550816631709 no 1846 0.45902789428831 2624 670767
SGTC_884 0851-0618 334 µM -0.103614341737196 0.451258284247486 no 1847 0.458737702933401 2691 9642473
SGTC_2302 7771753 200 µM -0.105035871122338 0.450689716038387 no 1848 0.458173672549394 2652 2203047
SGTC_290 2043-6722 48.1 µM -0.10518597059141 0.450629686733828 no 1849 0.458114121404909 2642 773758 YLR208W SEC13
SGTC_2470 5664817 21.68 µM -0.105793022179672 0.450386920029232 no 1850 0.457873286607373 2598 2859561
SGTC_2780 5215298 71.43 µM -0.106224151083718 0.450214518036496 no 1851 0.457702254778042 2633 2834131
SGTC_1703 st026983 48.3 µM -0.107522536639316 0.449695369975042 no 1852 0.457187223654495 2614 1104023
SGTC_408 cantharidin 100 µM -0.108616176594808 0.449258154400342 no 1853 0.456753464799897 2654 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_173 1273-0061 2.693 µM -0.111086597745351 0.448270756543392 no 1854 0.455773838205117 2699 2847414 YPL266W DIM1
SGTC_1294 1000-1494 117 µM -0.111303028053496 0.4481842671072 no 1855 0.455688027144059 2612 712797 YDL207W GLE1
SGTC_573 3702-0553 84.7 µM -0.11191615762375 0.447939262910457 no 1856 0.455444942579514 2620 1222756
SGTC_71 0417-1750 47.813 µM -0.113780892666713 0.447194244455358 no 1857 0.454705742829006 2646 6811472
SGTC_510 ag-490 170 µM -0.113857433207427 0.447163668140128 no 1858 0.454675404721066 2624 5328779
SGTC_1484 3473-2379 286 µM -0.115645391698645 0.446449506547601 no 1859 0.453966793425999 2598 671917
SGTC_3069 9117009 49.47 µM -0.115920812511112 0.44633951100114 no 1860 0.453857650447116 2620 41904981
SGTC_566 0958-0068 16.5 µM -0.11720670418802 0.445826015778026 no 1861 0.453348127182833 2711 6815365
SGTC_800 3448-7362 155 µM -0.119139978520375 0.445054172433368 no 1862 0.452582229005156 2615 15991913
SGTC_1246 0422-0085 105 µM -0.11995453670975 0.4447290291889 no 1863 0.452259581138161 2647 264295
SGTC_42 0133-0086 60.653 µM -0.120968720629962 0.444324254304892 no 1864 0.45185790526764 2615 162923 Model of phenazepam hydroxylation.
SGTC_2228 7354201 200 µM -0.122007567537076 0.443909696279991 no 1865 0.451446512510454 2637 753451
SGTC_2496 diffractaic acid 79.83 µM -0.123888802627981 0.443159134742388 no 1866 0.450701659426026 2814 94870 An apoptosis inducer which activates caspases.
SGTC_953 1188-0045 9.7 µM -0.124615131946119 0.442869403550185 no 1867 0.450414124110964 2741 6144426
SGTC_2710 st078562 53.7235 µM -0.125058525971015 0.44269254963974 no 1868 0.450238608469649 2607 17250908
SGTC_759 3486-0358 89.3 µM -0.125497142287336 0.44251761261961 no 1869 0.450064993639231 2620 875103
SGTC_2986 9022445 71.43 µM -0.126442840517906 0.442140470047357 no 1870 0.449690696214841 2684 6459286
SGTC_460 trequinsin 123 µM -0.128861036461359 0.441176337583525 no 1871 0.44873380397636 2627 5537 A vasodilator.
SGTC_1392 3455-1037 33.9 µM -0.129028853398951 0.441109441993749 no 1872 0.448667408973579 2768 981132
SGTC_136 0097-0015 404.482 µM -0.129309077911064 0.440997741973499 no 1873 0.448556544304102 2603 4861337
SGTC_822 1487-0950 154 µM -0.130144867297163 0.440664616689983 no 1874 0.44822590649455 2637 1958375
SGTC_2408 sulbentine 18.36 µM -0.1316608008487 0.440060509814748 no 1875 0.447626295962919 2767 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1485 3909-9022 254 µM -0.132956879790775 0.439544126642122 no 1876 0.447113741296982 2648 714516
SGTC_2083 5306046 65.942 µM -0.13310613516793 0.439484666970993 no 1877 0.447054721581173 2677 539837
SGTC_983 1491-0821 12.2 µM -0.135602199741544 0.438490499582515 no 1878 0.44606788318792 2778 46495113
SGTC_2204 7233102 200 µM -0.135936386889012 0.438357424181996 no 1879 0.445935784937175 2657 2172480
SGTC_3106 9121286 49.47 µM -0.136799129221453 0.438013907076665 no 1880 0.4455947859769 2853 15943471
SGTC_2695 st077686 51.995 µM -0.137922117780451 0.437566838035559 no 1881 0.445150985000054 2714 2876092
SGTC_680 0417-1641 114 µM -0.138469673809774 0.43734888128964 no 1882 0.444934617750174 2651 2835990
SGTC_2043 5101342 149 µM -0.138830951666496 0.437205083679883 no 1883 0.444791867463703 2678 678451
SGTC_2026 5148700 152 µM -0.138962624364128 0.43715267671929 no 1884 0.444739841932269 2658 79838
SGTC_1473 k844-0725 134 µM -0.140054085514393 0.43671830755169 no 1885 0.444308628698383 2669 54682906
SGTC_3183 9108214 49.47 µM -0.140147667735041 0.436681068146789 no 1886 0.444271659401517 2654 4974831
SGTC_2343 7990716 14.84 µM -0.140657636236498 0.436478144986713 no 1887 0.444070206832176 2676 6456862
SGTC_829 1635-0120 117 µM -0.140750543174981 0.436441177895016 no 1888 0.444033507411237 2795 285054
SGTC_1880 MG-132 525 µM -0.141149694735853 0.436282364296607 no 1889 0.443875842937853 2708 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2456 5770359 74.46 µM -0.141778597818623 0.436032158488524 no 1890 0.443627444872477 2806 3118787
SGTC_1895 st058434 18.3 µM -0.142064026363312 0.435918610671308 no 1891 0.443514716363719 2747 5393175
SGTC_1650 st011916 45.8 µM -0.143099451733029 0.435506747108492 no 1892 0.443105818970036 2688 242528
SGTC_54 0159-0055 9 µM -0.14486975709469 0.434802730884314 no 1893 0.442406852419928 2824 3319099
SGTC_946 3434-1334 87.4 µM -0.145816462532441 0.434426329097029 no 1894 0.442033139795761 2792 4047976
SGTC_843 0310-0051 143 µM -0.145923137554822 0.434383919762402 no 1895 0.441991032984894 2673 2065037
SGTC_2729 fluphenazine 10.66 µM -0.147462277315886 0.433772109229744 no 1896 0.441383576260186 2691 3372 An atypical antipsychotic.
SGTC_44 0929-0055 61.211 µM -0.149635825476224 0.432908390859803 no 1897 0.440525970872906 2680 1379590
SGTC_1252 0493-0875 34.8 µM -0.14982986913552 0.43283129786283 no 1898 0.440449421595379 2656 3960963
SGTC_2786 7743617 45.45 µM -0.150606778740936 0.432522659511497 no 1899 0.440142956865349 2722 583674
SGTC_2124 5246320 200 µM -0.150693959320277 0.432488028356293 no 1900 0.440108569290882 2780 579342
SGTC_567 1080-0542 68.4 µM -0.150796253981479 0.432447394023943 no 1901 0.440068220682449 2669 5950415
SGTC_1040 k898-0338 155 µM -0.152411680867029 0.431805795784625 no 1902 0.439431122354123 2723 20969351
SGTC_1642 st009582 77.7 µM -0.15256448004412 0.43174511790008 no 1903 0.439370868915116 2755 6739311
SGTC_1384 3089-0840 101 µM -0.152632530121467 0.431718095139656 no 1904 0.439344035117973 2732 1069836
SGTC_539 4859-0462 2.54 µM -0.154671608251554 0.430908523761396 no 1905 0.438540106962642 2857 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_584 0986-0246 15.4 µM -0.155038097619938 0.430763047844629 no 1906 0.438395641428508 2667 53315 YDR232W HEM1
SGTC_1817 st052116 64.4 µM -0.155515915189225 0.430573394929225 no 1907 0.438207304037281 2811 4361398
SGTC_508 roscovitine 141 µM -0.156722765481166 0.430094449450904 no 1908 0.437731672266723 2681 160355 A CDKinase inhibitor.
SGTC_706 4262-0057 46.9 µM -0.158380214585672 0.429436848980887 no 1909 0.437078601735454 2681 883298
SGTC_1414 3917-0015 5.4 µM -0.159438153828153 0.429017209011683 no 1910 0.43666184047501 2703 6618702
SGTC_2278 7948257 134.34 µM -0.160401142824174 0.428635301537019 no 1911 0.436282544716147 2783 1247028
SGTC_2804 7954240 19.48 µM -0.162368273213046 0.427855374160665 no 1912 0.435507926795513 2836 828705
SGTC_3000 9075062 71.4286 µM -0.163289421844088 0.427490254061907 no 1913 0.435145281133841 2731 17057871
SGTC_3277 9138724 49.47 µM -0.164784766132231 0.426897669627036 no 1914 0.434556697491622 2771 15943418
SGTC_321 4534-3890 65.3 µM -0.164835054459735 0.42687774391184 no 1915 0.434536905976711 2811 699746
SGTC_2928 9011484 9.79 µM -0.166181042573911 0.426344493302929 no 1916 0.43400723891908 2806 2994751
SGTC_1260 0700-1617 7.75 µM -0.168257506844294 0.425522108632757 no 1917 0.433190350913397 2798 2853078
SGTC_401 neomycin 50 µM -0.168296009770205 0.425506862578202 no 1918 0.433175206417343 2736 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_1952 st077036 64.1 µM -0.169495075499539 0.425032122791175 no 1919 0.432703622752612 2676 2937007
SGTC_167 3672-0051 66.205 µM -0.1708653657155 0.424489724117584 no 1920 0.432164815141792 2694 3237971
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.170897338819922 0.424477069983539 no 1921 0.432152244597644 2729 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2142 5622915 118.518 µM -0.170980968381037 0.424443971917967 no 1922 0.432119365128368 2726 5322196
SGTC_3224 9130643 49.47 µM -0.174216745252902 0.423163760037531 no 1923 0.43084756298414 2891 17644395
SGTC_3079 9117512 49.47 µM -0.175538527232851 0.422641038986374 no 1924 0.430328250187637 2665 7185044
SGTC_2702 st077768 96.8 µM -0.176965525486182 0.422076861285742 no 1925 0.429767734410946 2790 6484119
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.177228403271659 0.421972947388498 no 1926 0.429664493104752 3125 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_3060 1327-0027 12.5 µM -0.179935930730887 0.42090299656533 no 1927 0.428601433449326 2821 16000455 YPR107C YTH1
SGTC_474 dl-dihydrosphingosine 5 µM -0.183150287906213 0.419633517360138 no 1928 0.427340049497772 2888 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_230 MPP+ 141.667 µM -0.183390361608349 0.419538735964919 no 1929 0.427245868972046 2760 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_922 1866-0035 480 µM -0.183464087045124 0.419509630007693 no 1930 0.427216947434183 2739 3156169
SGTC_1677 st019204 53.9 µM -0.183889741600338 0.419341595084786 no 1931 0.427049976296518 2846 3945625
SGTC_292 k038-0015 474 µM -0.185251899917733 0.418803957167699 no 1932 0.426515731626787 2851 46368540
SGTC_2676 harmalol 100 µM -0.185261249972814 0.418800267264733 no 1933 0.426512064957488 2759 5459187 A monoamine oxidase inhibitor
SGTC_1448 4255-0083 152 µM -0.185411024196422 0.418741161383453 no 1934 0.426453331137639 2902 5399660
SGTC_231 b-estradiol 524 µM -0.185553319205166 0.418685008747846 no 1935 0.426397531795658 2753 450 A steroid.
SGTC_3331 9141060 1.957 µM -0.185734567210589 0.41861348683095 no 1936 0.426326459620106 2744 4906567 YPR165W RHO1
SGTC_1184 1269-1718 139 µM -0.188118796095557 0.417672902316714 no 1937 0.425391763493269 2878 5403821
SGTC_1 0258-0098 57.368 µM -0.188565037998872 0.417496910864971 no 1938 0.425216868403167 2802 6790032 YDR047W HEM12
SGTC_1238 0333-0287 48.8 µM -0.189414961305174 0.417161758955672 no 1939 0.424883799646441 2745 7226
SGTC_3090 9117696 49.47 µM -0.190135837610232 0.416877541561758 no 1940 0.424601343965369 2833 7923821
SGTC_955 1216-0110 33 µM -0.192057100477095 0.416120264485905 no 1941 0.423848739071819 2714 3619719
SGTC_2193 5925765 200 µM -0.192145702607096 0.416085348922151 no 1942 0.423814038162554 2869 877370
SGTC_1974 st069448 26.9 µM -0.193006596255805 0.415746129893068 no 1943 0.423476901078069 2877 6323587 YNR016C ACC1
SGTC_1063 disulfiram 1.84 µM -0.193192208497227 0.415673001080636 no 1944 0.423404220256315 2729 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1654 st012436 41.8 µM -0.193651440726962 0.415492082102553 no 1945 0.423224408323595 2772 4323132
SGTC_1472 k841-0093 193 µM -0.193760478539016 0.415449128232214 no 1946 0.42318171702205 2852 X1472
SGTC_1794 st048918 76.9 µM -0.194200847255938 0.415275661625578 no 1947 0.423009309742997 2706 672303
SGTC_1198 1612-1005 86.7 µM -0.194381394315011 0.415204546708844 no 1948 0.422938628629276 2938 6998509
SGTC_1323 1348-1351 11.2 µM -0.195967572022861 0.414579893547693 no 1949 0.422317773809352 2772 6989654
SGTC_773 4358-1457 44.6 µM -0.196127614978929 0.414516878946785 no 1950 0.422255141179188 2792 1186886
SGTC_466 geldanamycin 89.2 µM -0.196336341121634 0.414434699350547 no 1951 0.422173459393043 2806 5288382 HSP90 inhibitor.
SGTC_39 0986-0283 58.349 µM -0.196952328785211 0.414192194716949 no 1952 0.421932421563307 2893 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.197906414847689 0.41381665067318 no 1953 0.421559142562477 2735 364106
SGTC_1669 st015249 58.4 µM -0.198241955082506 0.413684595204379 no 1954 0.42142788170193 2832 722793
SGTC_723 4182-0001 115 µM -0.198791007536593 0.413468530766072 no 1955 0.421213115277454 2776 744821 YLR208W SEC13
SGTC_1816 st051957 91.6 µM -0.19895873783185 0.413402530359576 no 1956 0.421147510851519 2788 674121
SGTC_938 3126-1755 342 µM -0.199745063689472 0.413093150654551 no 1957 0.420839984083007 2892 1777771
SGTC_1847 st056231 15 µM -0.200310930584268 0.412870543850122 no 1958 0.420618707209982 2764 5393180
SGTC_2005 4024620 188 µM -0.202126021705574 0.412156693181129 no 1959 0.419909102656799 2750 236743
SGTC_260 nsc-65238 3.989 µM -0.20344479414251 0.411638219999516 no 1960 0.419393695570449 2880 3246252
SGTC_753 1322-0200 289 µM -0.204351232528212 0.411281944649823 no 1961 0.419039518391826 2922 5403907
SGTC_2114 5491910 81.25 µM -0.204671748334018 0.41115598349513 no 1962 0.418914297341382 2888 2849228
SGTC_3280 9140961 49.47 µM -0.205499471811395 0.410830734587028 no 1963 0.418590955362978 2745 4901226
SGTC_1405 3909-7894 12 µM -0.206128598202227 0.410583564186208 no 1964 0.418345230143329 2872 7104060
SGTC_468 gf-109203x 121 µM -0.208272933025664 0.40974136789379 no 1965 0.417507932275737 2867 2396 A protein kinase C inhibitor.
SGTC_1119 parthenolide 318.541 nM -0.208977319770545 0.409464807751536 no 1966 0.417232971959081 2973 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_353 1988-1175 58.3 µM -0.209000793678696 0.409455592073346 no 1967 0.417223809516809 2699 2788357
SGTC_625 k213-0058 121 µM -0.210846182494443 0.408731263401359 no 1968 0.416503650049224 2835 3655420
SGTC_2708 st078559 56 µM -0.21100551438449 0.408668739042836 no 1969 0.416441484187978 2818 17250902
SGTC_758 0868-0029 16 µM -0.211961064816376 0.408293814735633 no 1970 0.416068704952486 2905 762687
SGTC_425 3825-7017 13.1 µM -0.212399373853139 0.408121865779302 no 1971 0.415897737113727 3033 3397440
SGTC_1662 st014054 52 µM -0.21250175634272 0.408081703601328 no 1972 0.415857803854435 2772 2838777
SGTC_3248 9135562 49.47 µM -0.212514136719537 0.408076847143946 no 1973 0.415852975071974 2822 17650701
SGTC_216 k038-0035 28.382 µM -0.212558352772208 0.408059502603366 no 1974 0.415835729359768 2806 4444231 YPR107C YTH1
SGTC_1871 st057448 67.3 µM -0.213150928785715 0.407827071421219 no 1975 0.415604620914269 2961 691747
SGTC_2823 7987624 58.44 µM -0.213714611579984 0.407606003376289 no 1976 0.415384808097298 2976 2239440
SGTC_1750 st081859 2.357 µM -0.214782156398839 0.407187408777271 no 1977 0.414968582686844 2817 5291695
SGTC_2360 9040895 200 µM -0.214839423430426 0.407164956813834 no 1978 0.414946257517278 2849 4914414
SGTC_2664 lyso-paf C-16 73.48 µM -0.216248312788064 0.406612687558172 no 1979 0.41439709809185 2790 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2529 gangaleoidin 93.61 µM -0.21639122097635 0.406556679462375 no 1980 0.414341404408853 2788 4565183
SGTC_3308 9128332 17.569 µM -0.217447444539816 0.406142787227301 no 1981 0.413929830104336 2940 17332805 YDL196W YDL196W
SGTC_16 erodoxin 22.806 µM -0.217555282743269 0.406100535593204 no 1982 0.413887814544062 2838 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1268 0828-0275 2.46 µM -0.219715926657577 0.405254213854835 no 1983 0.413046200034331 2896 745337
SGTC_1686 st019653 115.5 µM -0.222493757734852 0.404166791746623 no 1984 0.41196476605342 2919 97252
SGTC_836 0330-0104 1.35 µM -0.223005362859518 0.403966596982451 no 1985 0.411765666322474 2797 46494820
SGTC_61 0978-8327 98.565 µM -0.225707753325821 0.402909550642706 no 1986 0.410714363703844 2789 6150059 YHR072W ERG7
SGTC_2069 5228469 200 µM -0.226074795919818 0.402766035609878 no 1987 0.410571623541804 2929 2835210
SGTC_1591 genipin 88.4 µM -0.226448796081467 0.402619813617319 no 1988 0.410426189815906 2950 442424 A DNA cross-linking agent.
SGTC_2546 rhodinyl acetate 100 µM -0.226833584562488 0.402469387956669 no 1989 0.410276573798245 2875 6708682
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.226947813350508 0.402424735186204 no 1990 0.410232161113489 2819 641818 YHR062C RPP1
SGTC_1530 rhein 70.4 µM -0.227133433616771 0.402352177741623 no 1991 0.410159993545317 2791 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1609 st001574 46.4 µM -0.227943863890072 0.402035426612932 no 1992 0.40984494087546 2807 3960012
SGTC_1769 st044406 64.4 µM -0.228844304564866 0.401683570984425 no 1993 0.409494965152863 2808 670903
SGTC_3236 9132701 49.47 µM -0.229370477260502 0.401478000943275 no 1994 0.409290490129039 2855 24282524
SGTC_70 0141-0289 43.283 µM -0.229476453649868 0.401436600398908 no 1995 0.409249309818995 2909 352408
SGTC_3341 9147222 25.867 µM -0.231539974041227 0.400630690320685 no 1996 0.408447667107633 2948 1939759
SGTC_3330 9141424 71.43 µM -0.231761632956116 0.400544146283805 no 1997 0.408361579093039 2945 27261020
SGTC_2720 fluspirilene 36.88 µM -0.23177374535932 0.400539417283418 no 1998 0.408356874998435 2906 3396 An atypical antipsychotic.
SGTC_614 0462-0418 107 µM -0.233424496203602 0.399895057458258 no 1999 0.407715896633416 2847 5188303
SGTC_2526 patulin 37.61 µM -0.233917165562623 0.39970279990509 no 2000 0.40752464333746 2963 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_483 fpl-64176 144 µM -0.234338372439094 0.399538448897007 no 2001 0.407361149113912 2822 3423
SGTC_1691 st019933 84.6 µM -0.235488512551486 0.399089765657977 no 2002 0.406914796924488 2816 6176082
SGTC_463 ikarugamyin 104 µM -0.235512960402923 0.399080229707114 no 2003 0.406905310388731 2820 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_664 1222-0054 14.9 µM -0.235891634925039 0.398932534375554 no 2004 0.406758379735313 2846 6813991
SGTC_3122 9126309 49.47 µM -0.236204267211747 0.398810608558724 no 2005 0.40663708422012 2833 17591206
SGTC_1048 3161-0300 24.5 µM -0.236288719447716 0.398777674089459 no 2006 0.406604319858672 2810 2165101
SGTC_2580 diallyl disulphide 81.36 µM -0.236520177765906 0.398687414255492 no 2007 0.40651452589626 2842 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_439 amiodarone 34.4 µM -0.23672939174719 0.398605833518797 no 2008 0.406433365825827 2884 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_3027 9089541 49.47 µM -0.236766497518651 0.398591364985676 no 2009 0.406418971858335 2919 9943819
SGTC_299 1273-0059 1.44 µM -0.237093569389052 0.398463836943174 no 2010 0.40629210052163 2927 2848077
SGTC_2693 st077581 40.7 µM -0.238904681523986 0.397757865860067 no 2011 0.405589747666229 2929 25238761
SGTC_2254 7938975 95.19 µM -0.239146466829629 0.3976636432776 no 2012 0.40549600578906 3035 2969277
SGTC_2045 5106652 78.05 µM -0.241294393356737 0.396826869217031 no 2013 0.404663477994692 2971 673349
SGTC_950 1165-0508 94.1 µM -0.241624414876435 0.396698343749626 no 2014 0.404535601104702 2917 6148369
SGTC_1167 k781-0610 148 µM -0.241971980897329 0.396562997784196 no 2015 0.404400937087757 2888 4525169
SGTC_1657 st012939 43.4 µM -0.243370881999911 0.396018376752275 no 2016 0.403859049293198 2989 24207257
SGTC_660 4031-1742 102 µM -0.244203985431101 0.395694128746513 no 2017 0.403536420284012 2821 6738706
SGTC_146 3448-8650 53.125 µM -0.246311340434626 0.394874258351215 no 2018 0.402720615966238 2865 2891488 YIL048W NEO1
SGTC_2531 methyl deoxycholate 70.07 µM -0.246492420724332 0.394803830384532 no 2019 0.402650535433771 2831 16667744 Haematoxylin.
SGTC_2179 6298986 200 µM -0.247178280432405 0.394537108601846 no 2020 0.402385126786641 2989 738374
SGTC_153 4077-0274 519.67 µM -0.249173301649323 0.393761552646433 no 2021 0.401613365209938 3136 3121976
SGTC_391 gliotoxin 8.33 µM -0.249755625627913 0.393535255972713 no 2022 0.401388168980865 3003 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1902 st060212 70.5 µM -0.252548727267954 0.392450331045144 no 2023 0.400308477718955 2857 688944
SGTC_1795 st049545 62.3 µM -0.252834476334401 0.392339384447681 no 2024 0.400198062389668 2908 5291882
SGTC_3146 9095609 49.47 µM -0.256774903508887 0.390810347246152 no 2025 0.398676272373508 2928 17173999
SGTC_636 0kpi-0074 126 µM -0.257452213459473 0.390547694169871 no 2026 0.398414850165474 2952 616434
SGTC_526 4469-0568 170 µM -0.257533278589205 0.390516261380653 no 2027 0.39838356440329 2845 2901964
SGTC_1445 4239-0156 97.7 µM -0.262788265364483 0.388480189592126 no 2028 0.39635689031732 3047 4008346
SGTC_158 k038-0087 26.446 µM -0.263081771509904 0.388366558846642 no 2029 0.3962437767167 2847 X158
SGTC_2462 5162487 171.77 µM -0.26433172127449 0.387882748563185 no 2030 0.395762159605466 2828 2259986
SGTC_2446 5162541 200 µM -0.265353771386043 0.387487279241191 no 2031 0.395368472522305 2841 1549321
SGTC_3270 9137563 49.47 µM -0.266041325447998 0.387221304562819 no 2032 0.395103691191946 2982 17015724
SGTC_1150 3909-7983 10.9 µM -0.26703043500727 0.38683876848336 no 2033 0.39472286394793 2907 23965914
SGTC_156 3474-0145 5.642 µM -0.267058464804276 0.386827929616959 no 2034 0.39471207337128 2800 2265471
SGTC_2921 7974240 10.71 µM -0.267607295321591 0.386615719664684 no 2035 0.394500807434668 3008 2979074 YDR527W RBA50
SGTC_9 0092-0002 10.449 µM -0.268268329616992 0.386360170184388 no 2036 0.394246391151179 2914 759368
SGTC_1378 2093-0007 380 nM -0.268727795412573 0.386182574167259 no 2037 0.394069580329923 2995 3618014
SGTC_1171 0368-0077 21.4 µM -0.268838896440872 0.38613963417902 no 2038 0.394026829903292 2878 3239779
SGTC_1831 st055328 12 µM -0.270542479011957 0.385481383038548 no 2039 0.393371470672992 3041 1103068
SGTC_2203 7227154 166.4 µM -0.272661653386913 0.384663010801674 no 2040 0.392556657135808 2884 896304
SGTC_1145 3546-0597 10.2 µM -0.273387873259851 0.384382680809606 no 2041 0.392277536797195 2941 875334
SGTC_2444 5485484 36.41 µM -0.275461538211465 0.383582553336259 no 2042 0.391480835622893 3018 6790631
SGTC_2001 4023502 57.655 µM -0.276706630779648 0.383102370227004 no 2043 0.39100268999146 3014 108941 YCR052W RSC6
SGTC_3039 9090270 49.47 µM -0.276782616971623 0.383073071155262 no 2044 0.390973514783319 3004 17173750
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.277433369664881 0.382822178637498 no 2045 0.390723680779378 3112 6728940
SGTC_837 0091-0265 12.5 µM -0.278072527334156 0.382575804341168 no 2046 0.390478342186398 2901 759367
SGTC_2600 tangeritin 87.95 µM -0.279073427005117 0.382190085880953 no 2047 0.390094237735952 2876 68077 A bioactive flavone.
SGTC_1214 0358-0031 63.7 µM -0.279337758504561 0.382088239482827 no 2048 0.389992815984679 3153 4301366
SGTC_2068 5226020 147 µM -0.279441745861106 0.382048175598026 no 2049 0.389952918971252 2942 1810509
SGTC_179 1273-0063 6.77 µM -0.279751858654418 0.381928703927683 no 2050 0.389833944331642 2888 3108139
SGTC_2022 5136654 200 µM -0.283041846043956 0.380661923163607 no 2051 0.388572379741246 3061 1713771
SGTC_1441 4106-0040 13 µM -0.283091595389208 0.380642777393096 no 2052 0.388553312049231 2904 2904180
SGTC_122 0236-0016 402.397 µM -0.283591145527289 0.380450544395162 no 2053 0.388361861746206 2946 6808838
SGTC_3281 9140613 49.47 µM -0.284813425083385 0.37998032084326 no 2054 0.387893543151153 2949 16013766
SGTC_1444 4112-3581 28 µM -0.285372704200614 0.379765219504596 no 2055 0.387679308676563 2920 2877249
SGTC_1103 duloxetine 36.1 µM -0.285620262801145 0.379670019192994 no 2056 0.387584491112482 3079 60835 A selective serotonin reuptake inhibitor.
SGTC_1142 3253-1408 9.78 µM -0.285850610605778 0.379581443958074 no 2057 0.38749627148645 2982 256655
SGTC_2767 sibutramine 71.45 µM -0.28638790750936 0.379374862694377 no 2058 0.387290517713827 3111 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.2889267143879 0.378399202535097 no 2059 0.386318730006041 2885 2346 DNA damaging agent; causes G2/M arrest.
SGTC_629 3448-6466 76.7 µM -0.289203194478694 0.378292998266574 no 2060 0.386212943707891 2953 573744
SGTC_3159 9100096 49.47 µM -0.291082563186413 0.377571320605687 no 2061 0.385494087684086 2818 25236875
SGTC_198 3454-2873 16.191 µM -0.291477523951475 0.377419709897149 no 2062 0.38534306563298 2929 710957
SGTC_2803 7707263 71.43 µM -0.291848022795744 0.377277506377074 no 2063 0.385201412945295 2937 2199229
SGTC_817 1391-0715 46 µM -0.292179618422428 0.377150248658106 no 2064 0.385074647098138 2964 1353946
SGTC_1715 st032160 10.2275 µM -0.293246748673836 0.37674080262518 no 2065 0.384666776796429 3033 5289825
SGTC_1726 st035556 14.5795 µM -0.293649298305307 0.376586384778979 no 2066 0.384512950505214 3125 5919439
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.293695721672316 0.376568578067002 no 2067 0.384495211912826 2939 66535 A nucleotide analog.
SGTC_819 1013-0258 27.7 µM -0.295719413385023 0.375792601982982 no 2068 0.383722185096867 2947 5753198
SGTC_2957 9076800 11.52 µM -0.295777470561519 0.375770347596176 no 2069 0.383700014737728 2966 16459615
SGTC_311 1315-0136 58 µM -0.29684177906879 0.375362451806749 no 2070 0.383293653584088 3109 6759207
SGTC_2316 5844804 197.44 µM -0.296854242188921 0.375357676145509 no 2071 0.383288895828748 3053 776813
SGTC_1644 st010134 20.9 µM -0.297268066968419 0.375199116194516 no 2072 0.383130929572555 3016 3818134
SGTC_3346 9158254 43.5805 µM -0.299294197904057 0.374423094312883 no 2073 0.382357790608854 3014 17639500
SGTC_2333 9017922 200 µM -0.299650915541472 0.374286521587318 no 2074 0.382221721339021 3068 3163164
SGTC_1101 ebselen 5.29 µM -0.301147326743626 0.373713778446487 no 2075 0.381651076764486 3096 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_988 1497-1057 103 µM -0.302762622232779 0.373095845885495 no 2076 0.381035385188986 2977 3533044
SGTC_2146 5545642 200 µM -0.302811795570598 0.373077039696439 no 2077 0.381016646824817 2974 825326
SGTC_1889 st059080 5.18 µM -0.304324843671833 0.372498527201261 no 2078 0.380440209842397 3111 176925 Isolated from Daphnopsis sellowiana.
SGTC_1207 2099-0101 141 µM -0.305281144283339 0.372133034792828 no 2079 0.380076017802566 3053 5837381
SGTC_2261 9010538 184.68 µM -0.308090672990491 0.371059916936988 no 2080 0.379006669077538 3054 6457250
SGTC_2680 butyl paraben 22.24 µM -0.309482235064908 0.370528771177208 no 2081 0.378477361843266 2960 7184 An antifungal and steroid mimetic.
SGTC_2404 5161160 200 µM -0.310932188088281 0.36997560059784 no 2082 0.377926086958714 2883 2831543
SGTC_878 0828-0289 13.7 µM -0.31123076409086 0.369861724422204 no 2083 0.377812598614615 2956 745350 YLR208W SEC13
SGTC_379 3970-0972 5.9 µM -0.312872560188421 0.369235751428216 no 2084 0.377188742754375 2999 2898042 YBL034C STU1
SGTC_2587 piperic acid 92.2 µM -0.313343791539467 0.369056147441923 no 2085 0.377009741599407 3018 5370536
SGTC_1412 3909-8563 178 µM -0.31390384677121 0.368842726512503 no 2086 0.376797034327109 3058 23767530
SGTC_1723 st034307 2.5525 µM -0.315001318901029 0.368424628785405 no 2087 0.376380326234674 3038 867466
SGTC_2851 9015922 71.43 µM -0.315051857297319 0.368405379206828 no 2088 0.376361140366776 3145 2996893
SGTC_2449 5812982 45.77 µM -0.316884507932122 0.367707564089047 no 2089 0.375665618795208 3051 776185
SGTC_148 3253-0744 288.01 µM -0.317400881761091 0.367511024065517 no 2090 0.375469719115439 2942 6893655
SGTC_3134 9127454 49.47 µM -0.318687223097546 0.367021573240368 no 2091 0.374981852182783 3069 24262820
SGTC_1516 st013856 110 µM -0.318752016068865 0.366996925327248 no 2092 0.374957283624697 3069 5281404 A mutagen and neurotoxin.
SGTC_2984 9022109 38.96 µM -0.319506235652847 0.366710052793015 no 2093 0.374671331815569 3076 6459207
SGTC_2843 9000894 45.46 µM -0.319674656396738 0.366646002981891 no 2094 0.37460748685102 3036 2242070
SGTC_2597 laccaic acid a 100 µM -0.320161305473827 0.366460952936566 no 2095 0.374423027156249 3101 5491415 A textile dye.
SGTC_3242 9133940 49.47 µM -0.320173741046587 0.366456224672296 no 2096 0.374418313947299 3117 17248444
SGTC_2522 biochanin a 4.94 µM -0.320181168798515 0.36645340049568 no 2097 0.374415498762488 3098 5280373 A possible chelator.
SGTC_798 1287-0182 476 µM -0.321364720233301 0.366003483560821 no 2098 0.373967007741425 3164 1649755
SGTC_2469 5655019 90.81 µM -0.321678353754418 0.36588428931276 no 2099 0.373848189066867 3098 2788239
SGTC_2182 6325192 200 µM -0.323011217567341 0.365377888170221 no 2100 0.3733433733381 3014 736248
SGTC_1722 st034304 3.6505 µM -0.32332220857775 0.365259765633658 no 2101 0.373225618230654 2977 4036148 YLR033W RSC58
SGTC_3301 9125354 19.7965 µM -0.323792444399798 0.365081182021422 no 2102 0.373047588403472 2947 41905162
SGTC_1861 st057647 17.4 µM -0.323799788687784 0.365078393079483 no 2103 0.373044808093644 3150 688668
SGTC_2653 dihydrofissinolide 100 µM -0.325318737306864 0.364501736555904 no 2104 0.372469925577758 3047 6857746
SGTC_1196 1588-0294 184 µM -0.325512173538874 0.364428322034382 no 2105 0.372396735360801 3027 6144269
SGTC_2946 9065502 71.43 µM -0.326400432604808 0.364091266479271 no 2106 0.372060705131855 3018 16489101
SGTC_2852 9023854 51.95 µM -0.32822185541619 0.363400444976051 no 2107 0.371371962067838 3137 19798528
SGTC_2418 pentamidine 31.67 µM -0.329223519460788 0.363020727174421 no 2108 0.370993373490518 3073 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1854 st056233 32.9 µM -0.330059108541363 0.3627040691986 no 2109 0.370677650030237 3084 5393174
SGTC_2955 9076254 12.21 µM -0.331506486183437 0.362155787773395 no 2110 0.370130971225933 3094 16459619
SGTC_1360 1598-0022 39.8 µM -0.332847477031817 0.361648059005596 no 2111 0.369624709041896 3102 761525
SGTC_1242 0402-0103 60.1 µM -0.333530629964902 0.361389495766778 no 2112 0.369366886190893 2962 432868
SGTC_2277 7947813 106.88 µM -0.334059863407314 0.361189232273227 no 2113 0.3691671931389 3193 1246798
SGTC_1658 st012944 20 µM -0.33586923723265 0.360504847504856 no 2114 0.36848473797413 3071 24207260
SGTC_1972 st070201 17.4 µM -0.335873765995548 0.360503135086977 no 2115 0.368483030345836 3130 2829099
SGTC_102 gallobenzophenone 83.616 µM -0.33668904351863 0.360194907597336 no 2116 0.368175661823849 3168 70837
SGTC_736 0958-0254 92.6 µM -0.33768378701533 0.359818953463603 no 2117 0.367800746947952 3102 6812352
SGTC_547 1120-0019 610 nM -0.338351511204121 0.359566669292848 no 2118 0.367549154959472 2964 3676939
SGTC_3025 9087895 49.47 µM -0.338944274156157 0.359342758764152 no 2119 0.367325855255826 3127 17173641
SGTC_3253 9135987 49.47 µM -0.341102119932443 0.358528061593868 no 2120 0.366513352679409 3119 4182430
SGTC_725 1497-0963 19 µM -0.341609027457677 0.358336771262659 no 2121 0.366322571286187 3128 3549977
SGTC_1590 st077108 57.8 µM -0.341613869561855 0.358334944182136 no 2122 0.36632074905505 3112 5489485
SGTC_1000 4048-0884 8.67 µM -0.342012946440639 0.3581843708857 no 2123 0.366170574647604 3122 13040088
SGTC_1362 1611-0397 101 µM -0.343237237395919 0.357722578724756 no 2124 0.365709996483733 3027 27816
SGTC_2614 arthonioic acid 13.39 µM -0.343248272381804 0.357718417367373 no 2125 0.365705846001895 2977 6710684
SGTC_3070 9117005 49.47 µM -0.343941736414093 0.357456941989744 no 2126 0.36544505167947 3078 8779016
SGTC_1341 1486-1360 280 µM -0.345140719341707 0.357005015129219 no 2127 0.364994291249381 3006 3976547
SGTC_162 k030-0015 37.8 µM -0.347074607013972 0.356276507039682 no 2128 0.364267634901989 3091 1809920 YMR134W ERG29
SGTC_1230 0170-0365 3.77 µM -0.347674858505589 0.356050494876207 no 2129 0.364042190049779 3140 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_80 0159-0065 512.242 µM -0.347889439853366 0.355969711017788 no 2130 0.363961608141308 3068 1548079
SGTC_3182 9108849 49.47 µM -0.348993465227475 0.355554178719279 no 2131 0.363547107753733 3124 17133045
SGTC_424 splitomicin 100 mM -0.349829480054712 0.355239634195551 no 2132 0.363233336696939 3103 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_784 4579-0127 173 µM -0.351236052807324 0.354710643977324 no 2133 0.362705632371632 3220 1948547
SGTC_533 1222-0222 6.71 µM -0.351447418507181 0.354631176790982 no 2134 0.362626356741784 3185 3982874
SGTC_549 1661-1316 519 µM -0.351497882666399 0.35461220471067 no 2135 0.362607430331418 3171 2857282
SGTC_1710 st031758 61.5 µM -0.351676056244663 0.354545222957616 no 2136 0.362540609625522 3190 5394341
SGTC_1411 3909-8223 150 µM -0.352120360024065 0.354378213040776 no 2137 0.36237399995049 3133 X1411
SGTC_2164 5685496 200 µM -0.353228703175729 0.353961718609403 no 2138 0.361958495517875 3159 759046
SGTC_219 mitoxanthrone 164.414 µM -0.353427582634401 0.353887001934244 no 2139 0.361883955213089 3070 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1985 st071382 65.5 µM -0.355241555912642 0.353205773528772 no 2140 0.361204317587125 3047 6123237
SGTC_1568 digitonin 820 nM -0.356019784802115 0.352913657620311 no 2141 0.360912874268036 3197 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1569 carminic acid 40.6 µM -0.356849732007404 0.352602224239833 no 2142 0.360602151633486 3200 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_404 fumagillin 50 µM -0.357544122128849 0.35234173382829 no 2143 0.360342250692001 3105 12015870 A methionine aminopeptidase binder.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.357609290469064 0.352317290420568 no 2144 0.360317862363258 2998 91467 include heat shock
SGTC_2514 salinomycin 42.74 µM -0.358632207371725 0.351933693693555 no 2145 0.359935124728781 3204 23682228 A polyether potassium ionophore.
SGTC_1630 st005209 31.3 µM -0.358779672532866 0.351878406257221 no 2146 0.35987996029431 3139 3367314
SGTC_58 0957-0393 9 µM -0.358818353988409 0.351863904377311 no 2147 0.359865490643606 3170 6997992
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.359551958659934 0.35158891297208 no 2148 0.359591107696483 3004 803109
SGTC_1169 aniline yellow 25.8 µM -0.359583408731533 0.351577125660562 no 2149 0.35957934635195 3059 6051 A DNA damaging agent.
SGTC_2127 5253358 187.912 µM -0.360110073769469 0.351379755752824 no 2150 0.359382409847773 2960 20612
SGTC_1149 3909-7961 23.3 µM -0.360964339680374 0.351059701283253 no 2151 0.359063052586303 3065 735261
SGTC_1683 st010134 710 nM -0.361168738183771 0.350983138139033 no 2152 0.358986655200459 3012 3818134
SGTC_3105 9121040 49.47 µM -0.361262525153262 0.350948009645709 no 2153 0.358951602627167 3088 41448907
SGTC_650 1328-0195 38 µM -0.361472842416287 0.350869238637313 no 2154 0.358873001555742 3143 2780821
SGTC_774 k060-0086 136 µM -0.361578622565485 0.350829622775728 no 2155 0.358833471000834 3224 5911235
SGTC_1557 sumaresinolic acid 42.3 µM -0.361661584934199 0.35079855356554 no 2156 0.358802468619064 3042 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_1227 3909-8010 46.6 µM -0.361819691940482 0.350739345629591 no 2157 0.358743387855613 3042 15982272
SGTC_2274 7947094 46.08 µM -0.362740039903411 0.350394765589163 no 2158 0.358399543223465 3043 2971028
SGTC_2591 skatole 100 µM -0.363114151144942 0.350254732793819 no 2159 0.35825980698791 3159 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_3073 9114972 49.47 µM -0.363727147727361 0.350025327334284 no 2160 0.358030884485298 3151 41905075
SGTC_2115 tiliquinol 12.7705 µM -0.364827361374875 0.3496137249519 no 2161 0.357620139672223 3100 71208 A bioactive hydroxyquinoline.
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.365390221266628 0.349403220994268 no 2162 0.357410069846761 3296 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_1664 st014217 9.02 µM -0.365435614723607 0.349386246313527 no 2163 0.357393130042375 3128 3982782
SGTC_1274 0865-0114 173 µM -0.36564835344829 0.349306697630798 no 2164 0.357313744539974 3085 870624
SGTC_2592 piperlongumine 83.33 µM -0.36745713888624 0.348630612221579 no 2165 0.356639028607718 3119 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_742 0kpi-0133 140 µM -0.369441143030026 0.347889586348678 no 2166 0.355899467940638 3206 2728852
SGTC_941 3237-0776 460 µM -0.370764364165295 0.347395685585469 no 2167 0.355406522905758 3229 760008
SGTC_916 4466-0038 42 nM -0.372546084960952 0.346731056147895 no 2168 0.354743153196749 3280 5722064 YGL116W CDC20
SGTC_2247 cerulenin 830 nM -0.372759993303784 0.346651294279759 no 2169 0.35466354047189 3285 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_109 0132-0036 33.701 µM -0.373007521940589 0.346559004603417 no 2170 0.354571422818997 2999 67274 A color developer.
SGTC_608 k048-0125 159 µM -0.373820157689329 0.34625608193194 no 2171 0.35426906066908 3172 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1408 3909-7976 48.8 µM -0.374418553865099 0.346033083257154 no 2172 0.354046470595746 3099 24152374
SGTC_925 2064-1272 59.6 µM -0.374907225127091 0.345851014328624 no 2173 0.353864732736425 3077 6815817
SGTC_1983 st071813 46.9 µM -0.375246465240033 0.345724641348797 no 2174 0.353738588208427 3123 11838595
SGTC_211 3455-0679 143.504 µM -0.376319013388325 0.345325211205864 no 2175 0.353339872905641 3155 748649
SGTC_1082 camptothecin 424.86 nM -0.376711422203192 0.345179116334245 no 2176 0.353194036745889 2886 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2046 4110841 106 µM -0.377925606956957 0.34472721824926 no 2177 0.352742929580116 3230 44119630 YMR134W ERG29
SGTC_270 tamoxifen 5.46 µM -0.379060098084091 0.344305180824609 no 2178 0.35232161807198 3270 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2737 bleomycin 30.5 nM -0.379489993227986 0.34414530788698 no 2179 0.352162016903288 3113 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1319 1306-0155 43.7 µM -0.382466676740983 0.343039079825968 no 2180 0.351057620801906 3091 3122360
SGTC_570 0987-0065 62.6 µM -0.384630360294177 0.342235830655177 no 2181 0.350255648585547 3050 3104428
SGTC_1615 st002656 86.5 µM -0.38465140718776 0.342228020671516 no 2182 0.35024785079728 3133 1584458
SGTC_1786 berberine 21.6 µM -0.385127751845232 0.342051278957879 no 2183 0.350071383931921 3103 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_719 2810-4230 27.3 µM -0.385137971548357 0.342047487444162 no 2184 0.350067598290479 3117 721079
SGTC_2963 9082507 9 µM -0.385936453715481 0.341751299521034 no 2185 0.349771866004015 3232 16459611
SGTC_3177 9107506 49.47 µM -0.386464760898962 0.341555383474481 no 2186 0.34957624797939 3160 8897194
SGTC_2819 7996655 46.38 µM -0.386996916928947 0.34135808327884 no 2187 0.349379245203064 3114 6456960
SGTC_143 4032-1194 15.74 µM -0.387118168873509 0.341313134420023 no 2188 0.349334363721927 3025 1806963
SGTC_2779 methotrexate 400 µM -0.388485699894608 0.340806338070673 no 2189 0.348828317279258 3189 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_710 3448-4187 58 µM -0.388991526668968 0.34061895531486 no 2190 0.348641207243459 3128 3946412
SGTC_69 0096-0274 206.684 µM -0.389486933906174 0.340435470581573 no 2191 0.348457987174184 3366 6741392
SGTC_1692 fluoroquinolonic acid 71 µM -0.390230824015912 0.340160025803981 no 2192 0.348182935277123 3206 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3284 9108171 64.8615 µM -0.390482135277443 0.340066990497535 no 2193 0.348090031469558 3158 8687505
SGTC_3307 9126885 69.2785 µM -0.390695950087932 0.339987844025277 no 2194 0.34801099638724 3076 24824909
SGTC_961 1252-1571 372 µM -0.390893761524207 0.339914627700075 no 2195 0.347937882714516 3252 6813498
SGTC_3033 9090887 49.47 µM -0.391112248694254 0.339833765643593 no 2196 0.347857133592869 3097 19325384
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.392179273416874 0.339438965950376 no 2197 0.347462878695874 3140 97141
SGTC_72 0744-0168 198.391 µM -0.393846895305254 0.338822297903229 no 2198 0.346847039675895 3018 677577
SGTC_1117 retinoic acid 1.10837 µM -0.394201110563956 0.338691368571793 no 2199 0.346716282915194 3244 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2200 6600604 21.907 µM -0.395198303632861 0.338322878713408 no 2200 0.3463482722558 3100 2904777
SGTC_2398 5228213 48.84 µM -0.395854830670975 0.338080358660464 no 2201 0.346106062357851 3294 80771 YMR134W ERG29
SGTC_2744 captopril 92.04 µM -0.396181057810792 0.337959875847392 no 2202 0.345985732084078 3174 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1134 3477-0009 42.5 µM -0.396377159395288 0.337887459232622 no 2203 0.345913406660119 3315 3973534
SGTC_2826 7992541 19.48 µM -0.396733266371158 0.337755970987741 no 2204 0.345782083044698 3101 2985066
SGTC_2630 antimycin a 100 µM -0.39680374078244 0.337729951500038 no 2205 0.345756095989753 3048 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2041 5107442 45.335 µM -0.39876305017991 0.337006876046121 no 2206 0.345033902669817 3257 793005
SGTC_1938 st074717 56.4 µM -0.400047226778478 0.336533282024683 no 2207 0.344560866341621 3109 17250979
SGTC_2279 7948423 32.93 µM -0.4007664561389 0.336268149191087 no 2208 0.344296038771503 3290 1247112
SGTC_1005 4092-0690 4.4 µM -0.401690394822069 0.335927672896807 no 2209 0.343955947161848 3126 1529343
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.404762123099336 0.334796693670936 no 2210 0.342826186519252 3214 140250 A respiratory chain inhibitor.
SGTC_2505 galangin 7.89 µM -0.405239992614534 0.33462088125163 no 2211 0.342650555336302 3043 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_616 4092-0450 108 µM -0.406537693528947 0.334143628607984 no 2212 0.34217378353039 3164 787165
SGTC_1907 st060210 83.7 µM -0.407056775224358 0.33395280206938 no 2213 0.341983144691435 3254 688793
SGTC_2059 5238311 157 µM -0.407382515037581 0.333833074434278 no 2214 0.34186353349089 3062 703021
SGTC_3325 9138760 55.175 µM -0.40804039591188 0.333591317935822 no 2215 0.341622008968691 3124 43844959
SGTC_2936 9038235 15.59 µM -0.408843648006548 0.333296234441351 no 2216 0.341327202940806 3089 4749415
SGTC_2886 9058944 51.95 µM -0.41007806189021 0.332842960022716 no 2217 0.340874342560666 3137 4949929
SGTC_2018 5133068 143 µM -0.410765223159222 0.332590741470985 no 2218 0.340622348001514 3080 785362
SGTC_117 lucigenin 22.078 µM -0.41078323862682 0.33258413001698 no 2219 0.340615742357532 3199 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1139 k015-0024 46.9 µM -0.41185709326261 0.332190132761526 no 2220 0.340222085659414 3242 2766652
SGTC_2314 7727897 200 µM -0.411971620337801 0.332148123713097 no 2221 0.340180112262648 3105 900724
SGTC_2242 6630449 61.2675 µM -0.412614873612842 0.33191221471288 no 2222 0.339944401108037 3246 691249 YDR170C SEC7
SGTC_2487 5918373 44.05 µM -0.413990256147089 0.331408025628332 no 2223 0.339440621405435 3288 2876279
SGTC_2434 5670830 169.91 µM -0.415141076345493 0.3309863914383 no 2224 0.339019315469513 3211 1549830
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.415710373062199 0.330777893325973 no 2225 0.338810974928372 3123 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_2344 7990960 76.95 µM -0.416039492973728 0.330657381034156 no 2226 0.33869055227812 3156 140813
SGTC_797 k781-0471 270 µM -0.418214924175805 0.32986125556054 no 2227 0.337894992549918 3132 23738129
SGTC_763 3453-1109 128 µM -0.41898729088861 0.329578783634241 no 2228 0.337612710300031 3295 1560353
SGTC_2160 5660466 132.927 µM -0.419146444585973 0.329520589610778 no 2229 0.33755455463289 3236 2859134
SGTC_2845 9003024 42.97 µM -0.419800662367978 0.329281420416379 no 2230 0.337315540491996 3339 2990173
SGTC_3167 9103034 49.47 µM -0.421791951142676 0.328553874435089 no 2231 0.336588440580075 3216 5127859
SGTC_1056 3448-1962 115 µM -0.421829817621182 0.328540045657171 no 2232 0.336574619907219 3217 715507
SGTC_113 0099-0221 2.5 µM -0.422250677792617 0.328386364003465 no 2233 0.336421027387537 3310 89219
SGTC_2723 salbutamol 83.58 µM -0.423005899289301 0.328110659494504 no 2234 0.336145478464626 3222 9884233 β2-adrenoceptor agonist
SGTC_3050 9093513 49.47 µM -0.423061836066383 0.328090242688703 no 2235 0.336125072959729 3170 25236664
SGTC_2912 7964298 10.93 µM -0.423076325557926 0.328084954138564 no 2236 0.336119787331889 3233 2975850
SGTC_3300 9124615 50.48 µM -0.423454694794601 0.327946864554503 no 2237 0.335981773328852 3317 24824903
SGTC_1076 itraconazole 331 nM -0.42359739457218 0.327894790969859 no 2238 0.335929727883986 3214 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.424080808407467 0.327718409881156 no 2239 0.335753440635996 3070 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2762 leflunomide 42.06 µM -0.424379199463901 0.327609556423645 no 2240 0.335644643956809 3148 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.424545992270342 0.32754871656715 no 2241 0.3355838354569 3142 16486 A toxic proline analog.
SGTC_2008 4012253 172 µM -0.424700339339817 0.327492420535104 no 2242 0.335527568198274 3120 603940
SGTC_2089 5281248 129.67 µM -0.425908643312986 0.327051843425813 no 2243 0.335087208256467 3184 2737878
SGTC_2425 5628681 7.85 µM -0.42649760830574 0.326837179715807 no 2244 0.334872645203247 3214 5714958
SGTC_1271 0832-2808 169 µM -0.42730117442819 0.326544391432697 no 2245 0.334579988759403 3272 3663794
SGTC_917 harmaline 728.087 nM -0.427302943231302 0.326543747067304 no 2246 0.33457934467722 3221 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_301 4119-0100 24.5 µM -0.42769008215018 0.326402726911461 no 2247 0.334438385768606 3183 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_3272 9137413 49.47 µM -0.428342451154393 0.326165149540395 no 2248 0.334200908276413 3148 17614870
SGTC_382 3229-0966 23.2 µM -0.42940851194334 0.325777067234854 no 2249 0.33381298019425 3302 5722370
SGTC_2256 7954252 200 µM -0.42949439009393 0.325745812881616 no 2250 0.333781737779144 3217 2972920
SGTC_1160 4092-0570 10.5 µM -0.429845555775593 0.3256180229648 no 2251 0.33365399592546 3161 4994975
SGTC_1432 4049-0298 68.4 µM -0.430622261189833 0.325335451061884 no 2252 0.333371526028766 3250 741646
SGTC_3286 9117135 37.221 µM -0.431429624610819 0.325041831926247 no 2253 0.333078006649384 3161 3438150
SGTC_2003 4023581 200 µM -0.432083048234221 0.324804276603708 no 2254 0.332840527378686 3276 16641307
SGTC_814 3342-0569 96 µM -0.432218774096527 0.324754941740729 no 2255 0.332791207787252 3269 4346283
SGTC_1202 1988-0068 29.6 µM -0.433175822615587 0.324407152396192 no 2256 0.332443520996107 3159 2850480
SGTC_2799 7812892 81.82 µM -0.434144476713989 0.324055301504655 no 2257 0.332091764750054 3294 20205235
SGTC_4 0960-0234 25.671 µM -0.434241680487213 0.324020002178494 no 2258 0.332056474413247 3253 6821112
SGTC_2095 5432005 200 µM -0.434410407187517 0.323958733223361 no 2259 0.331995220841767 3153 783734
SGTC_977 1348-1378 135 µM -0.435132575716192 0.323696549371501 no 2260 0.331733099677694 3129 X977
SGTC_1602 st001878 87.6 µM -0.436195897337915 0.323310668867449 no 2261 0.331347302163141 3311 595405 YLR310C CDC25
SGTC_724 3910-0327 137 µM -0.436570650531075 0.323174715810886 no 2262 0.331211375712017 3250 2885483
SGTC_1875 nocodazole 6 µM -0.436897399587987 0.323056196976759 no 2263 0.331092878951226 3301 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_455 paf C-16 10 µM -0.437781869434078 0.322735471092576 no 2264 0.330772207563663 3166 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1173 0443-0020 122 µM -0.438335283517348 0.322534859462701 no 2265 0.33057162613066 3160 5331295
SGTC_3342 9147791 14.508 µM -0.438903189220992 0.322329048347527 no 2266 0.330365842880964 3178 1838168
SGTC_3126 9127922 49.47 µM -0.43998431180809 0.321937396080597 no 2267 0.329974234921734 3353 45595682
SGTC_284 0988-0104 32.6 µM -0.441326010112336 0.321451621446907 no 2268 0.329488499341317 3235 4666532
SGTC_1555 citronellol 128 µM -0.441563272642228 0.321365750025951 no 2269 0.329402632990401 3244 8842 A terpine precursor.
SGTC_652 0437-0092 114 µM -0.442227611370135 0.321125359532151 no 2270 0.329162253757588 3221 3091274
SGTC_360 0957-0399 1.01 µM -0.442311898271671 0.321094865732096 no 2271 0.329131761077055 3305 6752301 YPR165W RHO1
SGTC_827 3253-0474 693 µM -0.443864124834415 0.3205335081408 no 2272 0.328570411656674 3291 5402065
SGTC_912 3474-0017 2.18 µM -0.444818928432074 0.320188410295581 no 2273 0.328225307110818 3326 3360550
SGTC_2892 9047358 58.44 µM -0.444842114218009 0.32018003211222 no 2274 0.328216928653671 3207 6466771
SGTC_1828 st055811 49 µM -0.444864909564266 0.320171795103608 no 2275 0.328208691370751 3291 5877589
SGTC_1057 3448-5381 134 µM -0.444874552320003 0.320168310758464 no 2276 0.328205206908039 3272 5497911
SGTC_2769 toremifene 3.73 µM -0.445318838217766 0.320007788229996 no 2277 0.328044677974881 3362 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2441 5730946 39.09 µM -0.445574418336132 0.319915461226818 no 2278 0.327952346411277 3296 1774275
SGTC_1287 0971-0001 34.6 µM -0.446597584690996 0.319545959397465 no 2279 0.327582819917712 3240 4665869
SGTC_2867 9039098 71.43 µM -0.448068249320895 0.319015163743358 no 2280 0.327051970853755 3164 6463460
SGTC_2869 9037858 32.47 µM -0.448408139315319 0.318892542594011 no 2281 0.326929334347914 3164 27187042
SGTC_1893 st059353 36.1 µM -0.450075611480738 0.31829126074177 no 2282 0.326327960774226 3245 3112488
SGTC_1235 benzylparaben 21.5 µM -0.450395776823271 0.318175865474439 no 2283 0.326212544781339 3275 7180
SGTC_1755 st041960 45.185 µM -0.452935719452236 0.317261035255252 no 2284 0.325297514598406 3301 2257073
SGTC_2072 5231554 129 µM -0.453003482179798 0.317236643896603 no 2285 0.32527311704054 3331 789545
SGTC_2338 7999974 200 µM -0.453173147775017 0.317175575835125 no 2286 0.32521203326032 3203 315925
SGTC_722 3534-0461 190 µM -0.454494771594923 0.316700051773794 no 2287 0.32473637711773 3247 658262
SGTC_338 4055-0136 114 µM -0.454601673196547 0.316661601493286 no 2288 0.32469791540686 3182 2900563
SGTC_1764 st044502 93.5 µM -0.454749198745693 0.316608542877693 no 2289 0.3246448408337 3312 8407
SGTC_830 4076-0286 57.8 µM -0.455307503924611 0.316407778608184 no 2290 0.324444014246638 3221 6866659
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.455754586761692 0.316247048438809 no 2291 0.324283231976737 3321 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_940 3232-1287 54.8 µM -0.456007802447513 0.316156030592614 no 2292 0.324192183755346 3306 1585493 YIL048W NEO1
SGTC_2567 aureobasidin a 60 nM -0.457213212817097 0.315722901179126 no 2293 0.323758901149432 3381 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_788 1182-0090 188 µM -0.459410553834908 0.314934001247859 no 2294 0.32296968542634 3380 5715185
SGTC_668 1682-0499 62.6 µM -0.459868841322173 0.314769570876466 no 2295 0.322805183246283 3263 682214
SGTC_894 0960-0238 55.9 µM -0.462104579479154 0.313967930520578 no 2296 0.322003163159594 3333 6741907 YDL195W SEC31
SGTC_875 0709-0210 25.7 µM -0.462441223036541 0.313847300387696 no 2297 0.321882471621001 3326 6251364
SGTC_1806 st050005 60.3 µM -0.463264866799799 0.31355224643634 no 2298 0.321587262767363 3219 5194765
SGTC_2873 9040596 71.43 µM -0.463425356949455 0.313494767917243 no 2299 0.321529753294054 3324 6463863
SGTC_1561 5-methoxyflavone 52.9 µM -0.464225361066761 0.313208319138651 no 2300 0.321243146466321 3276 94525
SGTC_1356 1502-0781 85.8 µM -0.464596803483992 0.313075359080792 no 2301 0.321110110902845 3208 567702
SGTC_1939 st074455 53.6 µM -0.465494842425592 0.312754001048434 no 2302 0.32078856475778 3394 1644229
SGTC_1222 0366-0074 1.18 µM -0.46613537047618 0.312524878702287 no 2303 0.320559303432371 3351 286520
SGTC_2754 granisetron 64.02 µM -0.467020071647794 0.312208532694134 no 2304 0.320242758883887 3356 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.468731698171785 0.311596892852936 no 2305 0.319630713258734 3394 16725076
SGTC_1329 1447-1697 50.6 µM -0.469112449358787 0.311460904190792 no 2306 0.319494630446249 3300 2840515
SGTC_222 nsc-310342 10.666 µM -0.469914056578284 0.311174687150827 no 2307 0.319208210569362 3308 432556
SGTC_3115 9123671 49.47 µM -0.47017337215152 0.311082121921676 no 2308 0.319115578382885 3354 3286988
SGTC_1236 0330-0013 258 µM -0.470472074362219 0.31097551205625 no 2309 0.319008890578014 3231 4617066
SGTC_1068 loratadine 26.9 µM -0.471208123182456 0.310712876438677 no 2310 0.31874605919475 3256 3957 A H1 histamine antagonist.
SGTC_3138 9097216 49.47 µM -0.472789544497087 0.310148922797827 no 2311 0.318181667093964 3309 25237486
SGTC_2781 5567276 71.43 µM -0.47283164098106 0.310133916783018 no 2312 0.318166649074773 3350 2853274
SGTC_3207 9114163 49.47 µM -0.475195769493577 0.309291690654184 no 2313 0.317323721088151 3444 849233
SGTC_1964 st076914 61 µM -0.47779409892126 0.308367184518429 no 2314 0.316398380819488 3303 24208661
SGTC_2771 fluoxetine 41.05 µM -0.478322895871541 0.308179182871763 no 2315 0.316210201371977 3388 3386 A selective serotonin reuptake inhibitor.
SGTC_1641 st009299 47.1 µM -0.478413858705753 0.308146848189434 no 2316 0.3161778358305 3324 4046054
SGTC_2625 euphol 100 µM -0.479361547492724 0.307810060567944 no 2317 0.315840721920052 3368 6708538 A triterpene alcohol.
SGTC_872 0588-0139 234 µM -0.480304930472957 0.307474963875545 no 2318 0.315505291749447 3250 2047100
SGTC_739 1486-1183 203 µM -0.481003676342472 0.307226867633992 no 2319 0.315256942930818 3350 4346692
SGTC_1512 0259-0544 12.2 µM -0.481026561093054 0.307218743680872 no 2320 0.31524881062526 3268 18476
SGTC_3252 9135871 49.47 µM -0.48105022371069 0.307210343688968 no 2321 0.315240401991663 3359 17682838
SGTC_561 1550-0330 72.9 µM -0.481077393996756 0.307200698634716 no 2322 0.31523074700799 3240 6812934
SGTC_3230 9131665 49.47 µM -0.481098233974133 0.307193300837863 no 2323 0.315223341590277 3276 15943720
SGTC_621 3584-0052 32.1 µM -0.481141390667277 0.30717798127953 no 2324 0.315208006236783 3364 2273927
SGTC_2031 5180455 200 µM -0.483612944462894 0.306301203008022 no 2325 0.314330293198543 3270 29949
SGTC_785 1270-0111 65.3 µM -0.483721027732154 0.306262885958177 no 2326 0.314291933916581 3242 6741994
SGTC_1835 st008666 49.2 µM -0.483793172863505 0.306237310666432 no 2327 0.314266330371952 3211 690455
SGTC_1455 4262-0120 131 µM -0.484397731459476 0.30602303307809 no 2328 0.314051814045376 3422 1529587
SGTC_2690 usnic acid 100 µM -0.484710470537858 0.30591221299574 no 2329 0.31394086907092 3470 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1023 4482-3888 16 µM -0.485751637661001 0.305543400203755 no 2330 0.313571633648765 3391 3303168
SGTC_1471 k673-0312 37 µM -0.488161169896741 0.304690628046797 no 2331 0.312717843080705 3326 24099884
SGTC_426 0988-0037 14.6 µM -0.488850244760595 0.304446948130304 no 2332 0.312473861566832 3406 5383008
SGTC_1258 0671-0043 57.1 µM -0.488861408423624 0.304443000999788 no 2333 0.312469909512259 3299 4298767
SGTC_1756 st041558 35.5 µM -0.489066290796686 0.304370564891096 no 2334 0.312397382819733 3414 3955792
SGTC_2294 7971431 200 µM -0.489215118614909 0.304317951667025 no 2335 0.31234470353986 3323 5741572
SGTC_2148 5546263 113.568 µM -0.491332272397581 0.303569939979779 no 2336 0.311595728927953 3235 792097
SGTC_3152 9099253 49.47 µM -0.491364411262156 0.303558591324569 no 2337 0.311584365320703 3310 25236131
SGTC_33 0986-0033 35.816 µM -0.492593151357156 0.303124849226314 no 2338 0.311150044070173 3323 2848082
SGTC_2552 juarezic acid 87.02 µM -0.492599112673413 0.303122745572813 no 2339 0.311147937571237 3303 1549512
SGTC_1025 k007-0731 70 µM -0.494612847475601 0.302412504677408 no 2340 0.310436715800745 3228 6256118
SGTC_1367 1812-0510 76.9 µM -0.495008010774244 0.302273218883943 no 2341 0.310297232919973 3309 1142582 YDR527W RBA50
SGTC_6 0844-0013 19.835 µM -0.495189661665317 0.302209200864561 no 2342 0.310233123795515 3405 1584900
SGTC_2900 5328528 85.29 µM -0.495582523158285 0.302070768108365 no 2343 0.310094492912069 3328 795359
SGTC_3088 9117578 49.47 µM -0.49561415863149 0.302059621943297 no 2344 0.3100833307277 3387 678341
SGTC_697 0508-1955 564 µM -0.49646573190468 0.301759655513628 no 2345 0.309782929448363 3408 6243113
SGTC_764 1951-2361 146 µM -0.497276190073582 0.301474296305558 no 2346 0.309497149872867 3268 5438930
SGTC_1374 2889-5571 141 µM -0.498927551889222 0.30089323430562 no 2347 0.308915211697776 3302 2853281
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.499047131821512 0.300851177527106 no 2348 0.30887309044963 3298 442882
SGTC_25 0118-0223 35.662 µM -0.501732515061807 0.299907415899486 no 2349 0.307927844663867 3415 5333628
SGTC_2212 7123476 200 µM -0.501989883052626 0.299817035891838 no 2350 0.307837318757784 3323 1085715
SGTC_183 3914-0051 30.55 µM -0.502439948910646 0.29965901575284 no 2351 0.307679041946102 3385 1596232
SGTC_2141 5621638 7.665 µM -0.503779225241544 0.299189013182523 no 2352 0.307208264024795 3389 2856238
SGTC_2113 5491891 107.031 µM -0.504262269790001 0.299019576761991 no 2353 0.307038543708356 3315 789979
SGTC_3213 9129884 49.47 µM -0.5044482721046 0.298954344781049 no 2354 0.306973201809705 3336 17190742
SGTC_3262 9137218 49.47 µM -0.504784710015886 0.298836370674375 no 2355 0.306855028038261 3285 17650664
SGTC_1719 st032227 49.2 µM -0.505710894208095 0.298511707590914 no 2356 0.306529809658 3279 3125804
SGTC_1572 epiandrosterone 68.9 µM -0.507279483300325 0.297962223283839 no 2357 0.30597936604105 3334 441302 A steroid.
SGTC_224 benfluorex 43.875 µM -0.507285699272097 0.297960046716439 no 2358 0.305977185624962 3391 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_373 0844-0104 25.9 µM -0.508524872827453 0.29752628596845 no 2359 0.30554265019717 3391 5375804
SGTC_2983 9022671 12.99 µM -0.509041399808887 0.297345565851262 no 2360 0.30536160280271 3426 6405161
SGTC_194 1486-1323 56.904 µM -0.509728134225659 0.29710537201973 no 2361 0.305120969871527 3336 5178754
SGTC_2197 6588183 93.1375 µM -0.510066401342333 0.296987091545884 no 2362 0.305002471440429 3321 884136
SGTC_1074 carmofur 3.8 µM -0.510837121222693 0.296717677572195 no 2363 0.304732556753199 3381 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2299 7976368 114.88 µM -0.511316428939423 0.296550186520344 no 2364 0.304564751427694 3375 2979718
SGTC_1547 harmine 94.2 µM -0.511325800122824 0.296546912251313 no 2365 0.304561470992119 3383 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2133 5320837 200 µM -0.511435316791513 0.296508648617549 no 2366 0.304523135230212 3408 2841355
SGTC_1587 estradiol valerate 56.1 µM -0.51164536794604 0.296435265933972 no 2367 0.304449613883277 3409 13791 A steroid.
SGTC_2818 7996756 12.99 µM -0.51192772732214 0.296336635039204 no 2368 0.30435079592303 3279 2241621
SGTC_188 3229-0966 278.469 µM -0.511970858149939 0.296321570343589 no 2369 0.304335702585382 3420 5722370
SGTC_1060 3448-7350 82 µM -0.512089154656948 0.296280253651608 no 2370 0.304294307244035 3398 570178
SGTC_2711 st079103 59.1 µM -0.512813863154704 0.296027196869705 no 2371 0.304040765703369 3319 54693780
SGTC_1748 st037455 53.6035 µM -0.513176299756007 0.295900676949204 no 2372 0.30391400145466 3423 580690
SGTC_2532 xanthone 78.9 µM -0.51396861679729 0.295624180224605 no 2373 0.303636966211713 3358 7020 An insecticide.
SGTC_770 0389-1121 67.2 µM -0.519268935150256 0.293777578123488 no 2374 0.301786606582881 3471 6753108
SGTC_2431 5490079 200 µM -0.519624646235258 0.293653841650519 no 2375 0.301662608287183 3351 5722345
SGTC_1689 st020265 53.493 µM -0.519745725949309 0.293611728768696 no 2376 0.301620406007414 3415 5758320 YPR016C TIF6
SGTC_2196 6573537 42.6665 µM -0.520661787040027 0.293293203091688 no 2377 0.301301199413647 3437 2903087
SGTC_2052 5265182 7.135 µM -0.520678172445325 0.293287507143553 no 2378 0.301295491212886 3402 1239884
SGTC_3121 9125696 49.47 µM -0.520830173828775 0.293234670369998 no 2379 0.301242540653622 3391 1235365
SGTC_133 0724-0033 378.92 µM -0.524482396877571 0.291966460320122 no 2380 0.299971530090321 3256 280309
SGTC_1034 k072-0165 12.7 µM -0.524483869519025 0.291965949470714 no 2381 0.29997101808595 3434 5835461
SGTC_2397 5161689 200 µM -0.524944090495589 0.291806322305041 no 2382 0.299811028961943 3466 2259942
SGTC_1967 st070177 51.4 µM -0.525622209852541 0.291571191437386 no 2383 0.299575361070534 3453 5729214
SGTC_1310 1188-0297 994 nM -0.526352895063962 0.29131793282968 no 2384 0.29932151888993 3344 1588352
SGTC_3093 9117344 49.47 µM -0.526966867080873 0.291105206920672 no 2385 0.299108298677605 3421 24824913
SGTC_2925 9010536 32.5 µM -0.52893447514179 0.290423969327741 no 2386 0.298425452719725 3345 2994177
SGTC_1798 st045719 60.953 µM -0.530574756790233 0.289856631781207 no 2387 0.297856746123791 3380 3980186
SGTC_2396 5342950 42.78 µM -0.531455671203098 0.289552157468421 no 2388 0.297551525968045 3358 1886677
SGTC_1704 st028805 70.8 µM -0.532132841682759 0.289318206205397 no 2389 0.297316996335418 3392 2876101
SGTC_1975 st070967 30.8 µM -0.532283301041859 0.289266237035049 no 2390 0.297264898064575 3450 261391
SGTC_40 0327-0103 19.753 µM -0.533692227774163 0.288779802031233 no 2391 0.296777243673549 3309 409036
SGTC_734 2023-0417 80 µM -0.533802039700789 0.288741905409019 no 2392 0.296739251217705 3409 3935732
SGTC_1898 st060199 18.6 µM -0.535475171904984 0.288164789317667 no 2393 0.296160660769362 3400 688866
SGTC_2528 xanthyletin 44.79 µM -0.537744811210781 0.287382790061939 no 2394 0.295376618938852 3340 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_308 4092-1169 104 µM -0.538318053893476 0.287185439458302 no 2395 0.295178744693799 3379 2268590 YDL196W YDL196W
SGTC_1483 3453-0561 55.9 µM -0.538729616432249 0.287043790149792 no 2396 0.295036717508164 3422 4546991
SGTC_1369 1866-0067 208 µM -0.539125361225037 0.286907616117867 no 2397 0.294900178604315 3455 3531355
SGTC_2034 5197015 53.07 µM -0.539884099291517 0.286646623338423 no 2398 0.294638482116921 3457 780676
SGTC_2213 7173844 200 µM -0.540351285817968 0.286485975275955 no 2399 0.294477398032584 3351 892728
SGTC_2484 5809818 12.04 µM -0.540359645677087 0.286483101020566 no 2400 0.294474515956124 3371 2870548
SGTC_3022 9087993 49.47 µM -0.540714624627072 0.286361066117853 no 2401 0.294352148340389 3425 17173644
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.542194259562895 0.285852662192652 no 2402 0.293842344707904 3462 7104
SGTC_2897 9048598 12.99 µM -0.542473384721822 0.285756802671958 no 2403 0.29374621881116 3334 6467404
SGTC_3315 9136395 68.55 µM -0.54318713998897 0.285511748371427 no 2404 0.293500479995868 3499 16876844
SGTC_1282 0886-0010 32.4 µM -0.543419390833992 0.285432031037358 no 2405 0.293420538883981 3491 2836211 YNL267W PIK1
SGTC_376 3970-0862 59.1 µM -0.544452845298882 0.285077438677705 no 2406 0.293064944573331 3424 3135186
SGTC_1509 1326-1131 80 µM -0.545543297280741 0.284703517544761 no 2407 0.292689955257427 3415 768313
SGTC_1377 2944-0135 198 µM -0.546057251447253 0.284527361445277 no 2408 0.292513291794986 3412 1894137
SGTC_1315 1237-0019 3.69 µM -0.546936259542001 0.284226205021718 no 2409 0.292211261840644 3453 825140
SGTC_2293 7624732 200 µM -0.547098009752368 0.28417080448768 no 2410 0.292155699767701 3401 894453
SGTC_900 1112-0045 141 µM -0.547504735253957 0.284031521091376 no 2411 0.292016009083401 3385 56211 YIL048W NEO1
SGTC_540 1187-0821 17.3 µM -0.548678762655318 0.283629657993959 no 2412 0.291612961557904 3352 847520
SGTC_443 clozapine 122 µM -0.549201730118794 0.283450736847937 no 2413 0.291433508615799 3397 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2890 9046729 58.44 µM -0.550994931309404 0.282837645934151 no 2414 0.290818574604794 3321 903329
SGTC_1154 4088-0362 150 µM -0.552935611145742 0.282174850954225 no 2415 0.29015375073433 3438 6618304
SGTC_1086 cerivastatin 2.18 µM -0.553076687556068 0.282126698685578 no 2416 0.29010544959126 3428 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2460 5552655 174.22 µM -0.553581547312489 0.281954412126354 no 2417 0.289932628728271 3443 5401989
SGTC_2712 st079126 47.7 µM -0.553982512271285 0.281817616438179 no 2418 0.28979540697794 3389 3152970
SGTC_2143 5623677 140.463 µM -0.555373289772856 0.281343378208706 no 2419 0.289319679175312 3429 5375313
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.555420363282518 0.281327333455735 no 2420 0.28930358368602 3447 3256 An antibiotic and ribosome inhibitor.
SGTC_2683 piperine 63.03 µM -0.557303253977668 0.280685922701411 no 2421 0.288660126422372 3373 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_2821 7996764 71.43 µM -0.557802360222926 0.280516019771046 no 2422 0.288489675419417 3551 2987135
SGTC_760 0568-0725 82.9 µM -0.558136900790543 0.280402165229668 no 2423 0.288375452204461 3479 3916171
SGTC_1965 Pectolinarigenin 58.4 µM -0.559663079404146 0.279883043309266 no 2424 0.287854635037768 3389 5320438 An anti-inflammatory.
SGTC_1254 0550-0035 264 µM -0.561044988877224 0.279413396266977 no 2425 0.287383434116108 3467 15121435
SGTC_1006 4099-6547 255 µM -0.56157120816011 0.279234659386867 no 2426 0.287204100816822 3465 3146833
SGTC_1339 1486-1321 22.7 µM -0.561759328132414 0.279170775600499 no 2427 0.287140003183671 3396 3469382
SGTC_2065 5221596 34.26 µM -0.562327104434397 0.278978007161203 no 2428 0.286946587306289 3455 788581
SGTC_1430 4049-0248 69.1 µM -0.562912393361353 0.278779360723134 no 2429 0.286747270294025 3489 22774488
SGTC_351 caspofungin 25 nM -0.564210362865885 0.278339077041679 no 2430 0.286305488046409 3446 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_319 1348-1596 45.5 µM -0.564378344013461 0.278282121008029 no 2431 0.286248336916349 3512 5380505
SGTC_873 0591-4978 488 µM -0.564613772215856 0.278202305800228 no 2432 0.286168247832814 3561 3305145
SGTC_3044 9093193 49.47 µM -0.564869907605105 0.27811548309305 no 2433 0.286081126571101 3449 25236277
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.567324345042533 0.277284168496254 no 2434 0.285246919897064 3379 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1611 st001856 99.4 µM -0.569738267828274 0.276467763324658 no 2435 0.284427615409535 3413 647478
SGTC_2093 5331342 194.4 µM -0.571462516166069 0.275885333318725 no 2436 0.283843081106 3497 33839
SGTC_2947 9072639 7.68 µM -0.572277347992036 0.275610302983964 no 2437 0.283567046682156 3472 16488146
SGTC_1670 st016595 4.04 µM -0.572558625546093 0.27551539463037 no 2438 0.283471790281762 3464 597879
SGTC_2677 mitomycin C 100 µM -0.574250566733159 0.274944841144558 no 2439 0.282899127659501 3468 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3053 9095903 49.47 µM -0.574786314376963 0.274764298686383 no 2440 0.282717911788891 3504 17174018
SGTC_1050 3232-1156 69.3 µM -0.574867279133538 0.274737019328002 no 2441 0.28269053042863 3401 700529
SGTC_123 0083-0120 66.675 µM -0.575947537280613 0.274373177068447 no 2442 0.282325321386361 3415 16001701
SGTC_1447 4239-0816 81.9 µM -0.578093900161964 0.273650966102396 no 2443 0.281600362540181 3413 1341554
SGTC_1694 st024011 44.9 µM -0.579243268711496 0.273264612139022 no 2444 0.281212519489953 3528 2787533
SGTC_1363 1636-0063 10.4 µM -0.579352214480867 0.273228004638002 no 2445 0.281175770205328 3478 6072185
SGTC_2822 7994718 71.43 µM -0.581485292238731 0.272511746633422 no 2446 0.280456713983633 3461 1018011
SGTC_3108 9121785 49.47 µM -0.581981578229829 0.272345234450775 no 2447 0.28028954470882 3468 17140271
SGTC_854 0422-0053 192 µM -0.582643895099005 0.272123094920451 no 2448 0.280066524700947 3506 3596728
SGTC_1168 k815-0004 80.5 µM -0.583061125390932 0.271983203114546 no 2449 0.279926076145849 3438 642433
SGTC_1673 st016611 27.3 µM -0.584231344835936 0.271591034928227 no 2450 0.279532337822258 3521 5226799
SGTC_3142 9086498 49.47 µM -0.584421116550125 0.271527464486425 no 2451 0.279468511560026 3420 25236367
SGTC_824 1304-0008 100 µM -0.588360090823494 0.270209647780278 no 2452 0.278145309734029 3476 768245
SGTC_1993 st073995 70.8 µM -0.588394581941321 0.270198122630588 no 2453 0.278133736796991 3462 3098394
SGTC_1629 st005085 44.9 µM -0.588828948881568 0.270053000685954 no 2454 0.27798801209808 3444 24207091
SGTC_2750 bromebric acid 70.15 µM -0.589637225853106 0.269783059286082 no 2455 0.277716944448347 3518 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1368 1852-0141 284 µM -0.58973068517369 0.269751855262103 no 2456 0.277685609809736 3480 2838987
SGTC_2125 5246583 200 µM -0.590335429911963 0.269549987911289 no 2457 0.277482895347042 3569 835267
SGTC_232 clozapine 119 µM -0.590599624590957 0.269461821939088 no 2458 0.277394358238796 3472 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2670 beta-carotene 100 µM -0.595478618019494 0.267836226968304 no 2459 0.275761793793203 3478 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2850 9015429 58.44 µM -0.595670557968127 0.267772377086319 no 2460 0.27569766525514 3454 6457570
SGTC_2205 7238770 200 µM -0.595843832208899 0.267714743042387 no 2461 0.275639779363082 3529 279867
SGTC_2832 7992762 51.95 µM -0.595982930593913 0.267668481009789 no 2462 0.275593314956213 3317 2985177
SGTC_3261 9137475 49.47 µM -0.596067353729762 0.267640405108377 no 2463 0.275565116140896 3404 17027690
SGTC_1813 st051246 8.6015 µM -0.596423379606765 0.267522020869715 no 2464 0.275446212834541 3471 5291959
SGTC_2178 5812956 200 µM -0.596811917967234 0.267392855853193 no 2465 0.275316480020586 3487 5403383
SGTC_1550 gossypolone 36.6 µM -0.598316628404425 0.266892929533673 no 2466 0.274814341693358 3520 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1286 0929-0070 131 µM -0.598716254248916 0.266760236892208 no 2467 0.274681058089495 3558 1420408
SGTC_3201 9113999 49.47 µM -0.599653407984851 0.266449193141181 no 2468 0.274368622743891 3513 16649224
SGTC_1070 indatraline 8.81 µM -0.600713133211996 0.266097688764396 no 2469 0.274015535070891 3494 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1241 0364-0022 50.8 µM -0.602294781680709 0.265573502791494 no 2470 0.273488966895235 3464 4563895
SGTC_2968 9090663 33.37 µM -0.602648085767904 0.265456483240076 no 2471 0.273371412087672 3420 25236811
SGTC_626 0214-0009 33 µM -0.603185373332471 0.265278575793071 no 2472 0.273192688462193 3545 3437874
SGTC_307 1501-1223 22.3 µM -0.606018929654192 0.264341326922496 no 2473 0.272251091597435 3513 2830329
SGTC_2021 4019055 173 µM -0.606160831541 0.264294434727758 no 2474 0.272203979732658 3568 44827708 YER133W GLC7
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.606901281398485 0.264049818065305 no 2475 0.271958213844626 3496 6708561
SGTC_55 0767-0285 6.563 µM -0.607280026339462 0.263924739654653 no 2476 0.271832545665826 3510 3116166
SGTC_66 0109-0187 42.4 µM -0.607660962441341 0.263798968095819 no 2477 0.271706179608523 3557 759417
SGTC_402 epigallocatechin gallate 10 µM -0.607895050447094 0.263721695721715 no 2478 0.271628541255086 3462 65064 An antioxidant.
SGTC_2471 5466956 24.79 µM -0.608243317667415 0.263606754194514 no 2479 0.271513054314286 3458 724419
SGTC_583 1488-1091 88.9 µM -0.608470364962117 0.263531833653377 no 2480 0.271437777604743 3586 4303273
SGTC_3237 9133362 49.47 µM -0.608892616824699 0.263392528862994 no 2481 0.271297809181318 3502 43845137
SGTC_2979 9012552 45.46 µM -0.608987331188815 0.263361286882251 no 2482 0.271266418119733 3603 17100905
SGTC_1793 st048256 72.231 µM -0.609126198367244 0.263315484307976 no 2483 0.271220396820305 3495 672022
SGTC_594 1487-1584 10.8 µM -0.610194256721145 0.262963342532022 no 2484 0.270866566917566 3460 5013332
SGTC_605 1315-0399 119 µM -0.610671482047511 0.262806077879643 no 2485 0.27070854463081 3599 24020461
SGTC_2499 avocadenofuran 51.48 µM -0.611857356749503 0.262415493563433 no 2486 0.270316068680874 3422 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2640 pentamidine 10.38 µM -0.612360667867575 0.26224981094137 no 2487 0.270149579347657 3534 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2801 7907800 81.82 µM -0.612544620525793 0.262189269804897 no 2488 0.270088742796576 3524 6620925
SGTC_3100 9120536 49.47 µM -0.612760312698018 0.262118291916606 no 2489 0.270017418131183 3461 16421196
SGTC_1671 st016596 74.5 µM -0.614770619663164 0.261457233505862 no 2490 0.269353107374882 3574 2829167
SGTC_3223 9129970 49.47 µM -0.615022722558929 0.26137439381024 no 2491 0.269269857233447 3567 17248386
SGTC_992 3909-8734 162 µM -0.615864074811661 0.261098027450564 no 2492 0.268992116911866 3504 4288319
SGTC_324 1315-0088 19.6 µM -0.616437367928628 0.260909798910806 no 2493 0.26880294849053 3507 6787421
SGTC_452 diindolylmethane 8 µM -0.616676013990548 0.260831465155341 no 2494 0.268724222611672 3529 3071 Inhibits expression of several cancer promoting factors.
SGTC_1423 4048-0112 5.59 µM -0.617523271771428 0.260553456986434 no 2495 0.268444818138173 3546 X1423
SGTC_1420 4'-methoxyflavone 42 µM -0.618298939509397 0.260299073277306 no 2496 0.268189150416334 3546 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2555 cholic acid 100 µM -0.618774772453828 0.260143085082843 no 2497 0.268032371854523 3569 6708657 Influences liver metabolism.
SGTC_2490 carminic acid 95.39 µM -0.624527625583707 0.25826099719198 no 2498 0.266140566773983 3527 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1830 st055982 50.3 µM -0.624954678055036 0.258121565789183 no 2499 0.2660004021527 3536 455313 An antimicrobial agent.
SGTC_2238 6671620 73.2395 µM -0.626084643370186 0.257752823728544 no 2500 0.265629712117737 3544 729941
SGTC_1620 st003704 16.5 µM -0.62633126043424 0.257672381443453 no 2501 0.265548843158991 3554 2834414
SGTC_111 0083-0039 52.457 µM -0.626469643352429 0.257627249002604 no 2502 0.265503471061866 3483 759313
SGTC_1520 flindersine 88 µM -0.627143380360414 0.257407573922616 no 2503 0.265282626725599 3637 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2999 9069765 71.4286 µM -0.627211937350477 0.257385226054561 no 2504 0.265260159650021 3532 2097066
SGTC_2185 6113692 200 µM -0.627500225974641 0.257291262191442 no 2505 0.265165694046566 3561 874150
SGTC_1228 0124-0032 52.5 µM -0.629649303208847 0.256591361171788 no 2506 0.264462029273134 3569 X1228
SGTC_2298 7976326 193.81 µM -0.629746717064212 0.256559659409805 no 2507 0.264430155926644 3473 2235818
SGTC_3026 9090633 49.47 µM -0.629758756205952 0.256555741607702 no 2508 0.264426216912931 3528 25236842
SGTC_2685 mycophenolic acid 18.85 µM -0.630320632562169 0.256372929326777 no 2509 0.26424241322593 3516 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_37 0566-0070 1.56 µM -0.631943405079913 0.255845324926079 no 2510 0.263711929657258 3567 1626686
SGTC_2340 7987427 183.45 µM -0.63200030600184 0.255826835286113 no 2511 0.263693338634864 3529 2239331
SGTC_2082 5219693 150 µM -0.633443343674849 0.255358161405852 no 2512 0.2632220839751 3580 2834649
SGTC_2401 5128683 200 µM -0.634393323472513 0.255049869401621 no 2513 0.262912082847084 3502 708373
SGTC_369 0957-0393 4.5 µM -0.634481136569344 0.255021381707915 no 2514 0.262883436760974 3542 6997992
SGTC_1200 1643-0193 18.4 µM -0.635081977626955 0.254826505841839 no 2515 0.262687475286413 3579 5403974
SGTC_3228 9131799 49.47 µM -0.636654607766773 0.254316810655762 no 2516 0.262174923420561 3538 17015818
SGTC_1124 fisetin 1.16336 µM -0.636816909443772 0.254264238528245 no 2517 0.262122055218643 3525 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1961 st076550 68.7 µM -0.639434853868334 0.253417031980922 no 2518 0.261270040591123 3563 1579337
SGTC_3335 9143315 29.6265 µM -0.640065276206836 0.253213239616794 no 2519 0.261065081304513 3522 4899691
SGTC_2681 menadione 3.18 µM -0.64066841950815 0.253018346260714 no 2520 0.260869068218237 3596 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_371 0195-0006 7.36 µM -0.641730098177377 0.252675478462133 no 2521 0.260524221584246 3499 3928593
SGTC_2283 7944793 200 µM -0.642633975604596 0.252383765339607 no 2522 0.260230815875016 3558 2970533
SGTC_1253 0550-0034 176 µM -0.642788889250636 0.252333787068009 no 2523 0.260180546788154 3560 5969915
SGTC_489 paxilline 115 µM -0.644898322037473 0.251653760991616 no 2524 0.25949653959566 3578 105008 A toxic potassium channel blocker.
SGTC_3048 9093155 49.47 µM -0.645979065657887 0.251305732828095 no 2525 0.259146456513032 3575 25236002
SGTC_2622 2-methoxyxanthone 59.94 µM -0.647163110088853 0.250924731371964 no 2526 0.25876319188406 3590 71034 A hepatoprotective.
SGTC_1087 pterostilbene 9.05 µM -0.647489660298599 0.250819707954833 no 2527 0.258657542125541 3613 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2325 6158266 200 µM -0.648818828950166 0.250392467748741 no 2528 0.258227742800648 3577 3623240
SGTC_2335 9018011 154.17 µM -0.649295665567498 0.250239290241016 no 2529 0.258073643420933 3609 6458208
SGTC_931 2812-0076 566 µM -0.649421309436555 0.250198937069541 no 2530 0.258033047007942 3603 3450959
SGTC_2816 7982706 58.44 µM -0.650257522551853 0.249930457577307 no 2531 0.257762945101278 3581 2981853
SGTC_165 k038-0023 64.381 µM -0.650789214082759 0.249759829124413 no 2532 0.25759128186556 3580 46368543
SGTC_2520 obtusaquinone 4.71 µM -0.652700977364053 0.249146824616045 no 2533 0.256974536140868 3666 5967872
SGTC_2170 morpholine 200 µM -0.652890442352949 0.24908611651852 no 2534 0.256913455522829 3595 121171 Reacts with secondary amines.
SGTC_1135 dihydrocapsaicin 536.708 nM -0.652911324531577 0.24907942596256 no 2535 0.256906723889668 3569 107982 A Capsaicinoid.
SGTC_632 0781-2353 4.65 µM -0.653455111003641 0.248905232892322 no 2536 0.256731459793561 3624 6811515 YHR007C ERG11
SGTC_1456 k015-0012 13 µM -0.653508659839721 0.248888082909238 no 2537 0.256714204201975 3666 2989616
SGTC_3077 9117319 49.47 µM -0.653528278618488 0.248881799798003 no 2538 0.256707882392478 3607 17154678
SGTC_1768 st044301 37.178 µM -0.654206942885852 0.248664502725756 no 2539 0.256489244569756 3596 3931349
SGTC_1992 st073643 23.3 µM -0.654457685939065 0.248584244518496 no 2540 0.256408489980056 3600 3161292
SGTC_767 0929-0023 86 µM -0.654460866326373 0.248583226624057 no 2541 0.256407465786039 3663 1204563
SGTC_2383 9036125 200 µM -0.655048664300341 0.248395137894667 no 2542 0.256218211249269 3554 79580
SGTC_1510 1123-0200 71.5 µM -0.655872384451829 0.248131684412569 no 2543 0.255953118953463 3687 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1067 clotrimazole 1.36 µM -0.655919137529952 0.248116735672644 no 2544 0.255938077018904 3622 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3021 9087658 49.47 µM -0.657599672548893 0.247579723733793 no 2545 0.255397702513785 3603 25237042
SGTC_1892 st058411 7.36 µM -0.657670711522761 0.247557037043501 no 2546 0.255374873138465 3579 3934738
SGTC_530 4358-1714 28 µM -0.658801206098029 0.247196156845244 no 2547 0.25501171635875 3605 1564641
SGTC_2989 9073649 71.4286 µM -0.660065619377751 0.246792860209412 no 2548 0.254605860244129 3608 21367202
SGTC_2181 6316240 54.2555 µM -0.660341420264759 0.24670493771555 no 2549 0.254517377610489 3590 12779990
SGTC_2175 5807670 165.306 µM -0.662000159277438 0.246176502714949 no 2550 0.253985559806269 3580 241186
SGTC_1698 5-fluorocytosine 1.055 µM -0.66211657447309 0.246139438397092 no 2551 0.253948257173809 3639 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_752 1896-0090 130 µM -0.663457121976546 0.245712850076217 no 2552 0.253518916113312 3614 772567
SGTC_692 k241-0027 77.8 µM -0.663687311047253 0.245639639387714 no 2553 0.25344523117304 3664 3600480
SGTC_389 tpck 16.7 µM -0.664697969621088 0.245318342258127 no 2554 0.253121846367705 3596 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_3144 9087057 49.47 µM -0.665272598028164 0.245135763684172 no 2555 0.252938076854164 3565 17249618
SGTC_610 4215-0184 155 µM -0.666099549213219 0.244873142072578 no 2556 0.252673736328117 3637 5605015
SGTC_2329 6138490 200 µM -0.66645078610348 0.244761642749349 no 2557 0.252561505124529 3607 720019
SGTC_1059 3448-6867 171 µM -0.667235228672871 0.244512722019788 no 2558 0.25231094597534 3604 3934407
SGTC_3298 9116858 71.43 µM -0.667401670197699 0.244459924038182 no 2559 0.252257799671773 3636 2506942
SGTC_735 3076-0345 636 µM -0.667657589733025 0.244378754148932 no 2560 0.252176093736877 3648 2888990
SGTC_2246 7293507 91.5585 µM -0.668078661182112 0.244245234711923 no 2561 0.252041691095865 3648 887656
SGTC_855 0428-0020 25 µM -0.669616801001866 0.2437578334428 no 2562 0.251551050525077 3611 6812414
SGTC_1108 betulinic acid 729.144 nM -0.669692897475863 0.243733733851177 no 2563 0.251526790144567 3641 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3238 9133470 49.47 µM -0.669748786539497 0.243716034722775 no 2564 0.251508972892894 3643 3534688
SGTC_63 0099-0242 26.702 µM -0.671017521926984 0.243314434245933 no 2565 0.251104683650385 3630 3898502 YLR359W ADE13
SGTC_1364 1653-0028 37.6 µM -0.671237454839547 0.243244853943676 no 2566 0.251034635843123 3602 5718652
SGTC_2876 9059903 25.97 µM -0.67300500413601 0.242686044137715 no 2567 0.250472053669559 3613 6916095
SGTC_1897 st060201 15 µM -0.676432980123338 0.241604275144216 no 2568 0.249382891948897 3636 611878
SGTC_2812 7970281 58.44 µM -0.678326536440922 0.241007848522454 no 2569 0.248782338462715 3659 2233435
SGTC_2933 9026794 32.47 µM -0.678632329173129 0.240911606003993 no 2570 0.248685426610912 3639 17586027
SGTC_2488 5268135 45.7 µM -0.680192261484737 0.240420972106935 no 2571 0.248191365810194 3644 1270356 YLR208W SEC13
SGTC_1700 st030840 7.9285 µM -0.680394226355506 0.240357489416388 no 2572 0.248127437916177 3653 5499307
SGTC_2718 lomofungin 53.02 µM -0.680976282192535 0.240174585568732 no 2573 0.24794324905796 3667 5351222 A RNA synthesis inhibitor.
SGTC_2730 imipramine 71.33 µM -0.684576418672629 0.239044974661794 no 2574 0.246805625871193 3668 3696 A tricyclic antidepressant.
SGTC_2173 5763948 167 µM -0.688565068166376 0.237796859420718 no 2575 0.245548504948548 3665 2867177
SGTC_1846 st056244 14.8 µM -0.688898663072774 0.237692634199231 no 2576 0.245443520411325 3662 5393182
SGTC_904 1141-0088 396 µM -0.689010043581715 0.237657841113252 no 2577 0.245408473595468 3608 1378119
SGTC_674 0498-0004 451 µM -0.690539871205256 0.23718023585928 no 2578 0.244927372698344 3634 4231473
SGTC_2610 ononetin 44.17 µM -0.690776538641271 0.237106396481771 no 2579 0.244852990769556 3664 259632
SGTC_390 dec-rvkr-cmk 16.7 µM -0.691103812664549 0.237004308992748 no 2580 0.244750152237016 3703 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_3018 9082602 49.47 µM -0.693462291934546 0.236269336853103 no 2581 0.244009741007763 3656 17332089
SGTC_429 1112-0049 25.5 µM -0.693501186384115 0.236257226717147 no 2582 0.243997540780723 3635 2836170
SGTC_820 1582-0060 59.9 µM -0.694604088028578 0.235913970699882 no 2583 0.243651724811305 3665 3848840
SGTC_1922 5578187 25 µM -0.694884461612026 0.235826753887181 no 2584 0.243563855588742 3695 1350412
SGTC_1924 st058459 75.1 µM -0.695273410492567 0.235705791609349 no 2585 0.243441987158476 3629 688683
SGTC_3158 9100007 49.47 µM -0.695535297913561 0.235624364455769 no 2586 0.243359949156556 3681 19297233
SGTC_3178 9107506 49.47 µM -0.695974709503017 0.235487775595907 no 2587 0.243222334080303 3688 8897194
SGTC_691 1548-0686 185 µM -0.696399171361442 0.235355875280802 no 2588 0.243089440921776 3663 46495133
SGTC_325 2810-4341 181 µM -0.697361818115104 0.235056886715831 no 2589 0.242788195056093 3675 774970
SGTC_3075 9116269 49.47 µM -0.698369357376381 0.234744179838213 no 2590 0.242473117279588 3680 17015205 YNL244C SUI1
SGTC_1418 3966-3099 2.4 µM -0.698620738265567 0.234666195386686 no 2591 0.242394539962176 3669 740335
SGTC_1652 st011932 78 µM -0.699182766562794 0.234491892402883 no 2592 0.242218909554639 3632 1551076
SGTC_2342 7990637 118.86 µM -0.699678679694657 0.234338153350712 no 2593 0.242063997035126 3731 2033102 YER133W GLC7
SGTC_1179 1021-1431 9.29 µM -0.700438987729785 0.234102557052967 no 2594 0.241826597641077 3675 2840958
SGTC_164 4100-3994 89.624 µM -0.70160504056648 0.233741487786747 no 2595 0.24146275364768 3693 4615967
SGTC_96 0929-0093 37.281 µM -0.701831230788828 0.233671483553903 no 2596 0.241392209859087 3643 6991579
SGTC_1633 st005664 67.9 µM -0.702656941650593 0.233416030723489 no 2597 0.241134783745853 3703 2063822
SGTC_2836 9010338 19.48 µM -0.702912458377704 0.233337012090495 no 2598 0.2410551533264 3613 2994051
SGTC_602 3130-1533 38.1 µM -0.703305795986828 0.233215401320667 no 2599 0.240932599719629 3693 720941
SGTC_2618 avocadyne 43.43 µM -0.703496485953427 0.233156457116527 no 2600 0.240873197964049 3633 3015189
SGTC_588 3970-1144 52.9 µM -0.703991771937498 0.233003397835918 no 2601 0.240718948852422 3608 1888707
SGTC_149 3970-0822 46.1 µM -0.704233740584026 0.23292864204536 no 2602 0.240643611034651 3732 3114250 YBL034C STU1
SGTC_1539 benzyladenosine 56 µM -0.70470221583885 0.232783945307445 no 2603 0.240497786048389 3673 92208 A nucleotide analog.
SGTC_2202 7226349 200 µM -0.704998294637283 0.232692521981187 no 2604 0.240405648720953 3643 844334
SGTC_2996 9066192 71.4286 µM -0.705146596542965 0.232646736763622 no 2605 0.240359505595505 3707 6472854
SGTC_3217 9129673 49.47 µM -0.705310010954902 0.232596291664738 no 2606 0.240308665904683 3677 17248312
SGTC_3137 9097352 49.47 µM -0.706628747282791 0.232189427883018 no 2607 0.239898609682318 3770 44120435
SGTC_1788 fluconazole 20 µM -0.706679259251779 0.232173851532674 no 2608 0.239882910763507 3678 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_1945 st075991 56.6 µM -0.707388112192381 0.231955324264793 no 2609 0.239662661212354 3610 1084980
SGTC_1928 4'-methoxychalcone 40.3 µM -0.707537459049508 0.231909297788844 no 2610 0.239616271339842 3707 641818
SGTC_2620 irigenin 100 µM -0.708829872317807 0.231511207808421 no 2611 0.239215028880948 3702 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1771 st048882 4.1505 µM -0.709053473634363 0.231442372662112 no 2612 0.239145646917076 3684 4580403
SGTC_2216 7189485 200 µM -0.709441271222868 0.231323017138193 no 2613 0.23902534205115 3682 731273
SGTC_2911 7942208 15.64 µM -0.711555631414672 0.230672868043151 no 2614 0.238369995038388 3682 1243384
SGTC_864 0469-0573 172 µM -0.714074987895968 0.229899520474837 no 2615 0.237590405703584 3688 689425
SGTC_522 1273-0010 11.6 µM -0.717110829265394 0.228969562719883 no 2616 0.236652857136577 3749 5705015
SGTC_3042 9091578 49.47 µM -0.717858032441312 0.228740998922772 no 2617 0.236422413423303 3655 25236497
SGTC_3 0833-0587 95.581 µM -0.718233719723832 0.228626127437613 no 2618 0.236306595002615 3652 5382644
SGTC_2157 5649910 96.377 µM -0.719005080334165 0.228390375038742 no 2619 0.23606889473133 3679 2858091
SGTC_1371 2421-0008 32.7 µM -0.719157495806107 0.228343808178669 no 2620 0.236021942408596 3694 2827552
SGTC_1031 k035-0009 16 µM -0.719494761046706 0.22824078391359 no 2621 0.235918064514943 3724 5180959
SGTC_2122 5258151 111.688 µM -0.720990413699656 0.227784222563883 no 2622 0.235457706409217 3713 2173356
SGTC_962 1254-0300 21.5 µM -0.721522923702326 0.227621793284306 no 2623 0.235293920924464 3677 7340576
SGTC_707 0865-0008 204 µM -0.722060749288245 0.227457808827459 no 2624 0.235128564374517 3700 723043
SGTC_405 ebelactone b 50 µM -0.722326006313367 0.227376955761227 no 2625 0.23504703371907 3702 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_895 0964-0006 13.7 µM -0.722680852861894 0.227268820210035 no 2626 0.234937990828123 3684 6738897
SGTC_859 0439-0102 54.6 µM -0.722993356894771 0.227173612075099 no 2627 0.234841982772657 3717 610143
SGTC_708 3448-5400 146 µM -0.723348837096508 0.227065338066965 no 2628 0.234732797869651 3691 3462195
SGTC_2051 5263410 176 µM -0.724406562224922 0.226743342791104 no 2629 0.23440808615455 3760 227584
SGTC_1297 1068-0111 14.1 µM -0.724587841334809 0.226688183234532 no 2630 0.234352460124639 3671 767057
SGTC_1713 st033146 12.748 µM -0.724588646488168 0.226687938259587 no 2631 0.234352213077251 3690 674619
SGTC_1751 st044839 27.194 µM -0.725717720602643 0.226344554629851 no 2632 0.23400591805406 3703 5291326
SGTC_1071 trifluoperazine 6.31 µM -0.727667461771053 0.225752275041852 no 2633 0.233408586551708 3795 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_17 0960-0276 49.807 µM -0.727877998807028 0.225688371967677 no 2634 0.233344136117083 3710 6821114
SGTC_1016 4226-1401 38 µM -0.728300585097973 0.225560137715055 no 2635 0.233214802128198 3711 2901613
SGTC_2012 4023501 200 µM -0.728628433850858 0.225460680078913 no 2636 0.233114490303964 3717 3477460
SGTC_1712 st032288 53.4 µM -0.728683034031228 0.225444118740424 no 2637 0.23309778662381 3697 2883011
SGTC_479 n-linoleoylglycine 10 µM -0.730282081793542 0.224959400750183 no 2638 0.232608889249822 3753 6433346 An anti-infammatory.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.731510576596656 0.224587409733036 no 2639 0.232233673318477 3541 4000243
SGTC_3334 9142812 21.919 µM -0.732039309417203 0.224427415712102 no 2640 0.232072287575748 3779 45283678
SGTC_2118 5526350 200 µM -0.732732676050424 0.224217701732803 no 2641 0.231860745112987 3759 743594
SGTC_2286 7945697 125 µM -0.732792729815564 0.224199543255308 no 2642 0.231842428084896 3738 1245733
SGTC_2608 thymoquinone 42.66 µM -0.733562775652954 0.223966778249937 no 2643 0.231607627474177 3676 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3176 9106582 49.47 µM -0.735920759900175 0.223254874995809 no 2644 0.230889461267386 3618 17018027
SGTC_3297 9117502 71.43 µM -0.736127248359445 0.223192595087004 no 2645 0.230826630786372 3721 7453720
SGTC_3312 9133330 71.43 µM -0.736395520659053 0.223111695051538 no 2646 0.230745014930091 3778 17617324
SGTC_3226 9131256 49.47 µM -0.737042464525177 0.222916671739034 no 2647 0.230548263028494 3627 17178073
SGTC_2669 eugenol 100 µM -0.737638817638835 0.222736985219699 no 2648 0.230366980125007 3701 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1080 nisoldipine 24.4 µM -0.738492699661511 0.222479846709329 no 2649 0.230107550892473 3732 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.738550215901238 0.222462532324339 no 2650 0.230090081998136 3770 94937 An inhibitor of serotonin biosynthesis.
SGTC_1834 st055981 52.8 µM -0.738973576274209 0.22233510980232 no 2651 0.229961521363778 3777 471719 YDL150W RPC53
SGTC_2807 7945238 51.95 µM -0.739424955955158 0.222199299933434 no 2652 0.229824496481008 3774 17148797
SGTC_2248 tofa 1.1 µM -0.740878481149205 0.221762289115831 no 2653 0.229383562043343 3671 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_675 1309-0189 238 µM -0.741548839987795 0.22156090738648 no 2654 0.229180365081903 3761 4246530
SGTC_1012 4112-3522 18 µM -0.741908858613726 0.221452797759786 no 2655 0.229071279100637 3722 3112398
SGTC_431 k089-0097 107 µM -0.742873627857556 0.221163236930356 no 2656 0.228779096772875 3695 5499420
SGTC_2326 6164455 177.58 µM -0.744057334553772 0.220808261453837 no 2657 0.228420894784089 3743 2888790
SGTC_252 miconazole 1.30953 nM -0.74439580820356 0.220706818413428 no 2658 0.228318527096168 3706 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_658 3253-0951 102 µM -0.744499171972743 0.22067584485345 no 2659 0.228287270984208 3754 1184878
SGTC_2570 licareol 100 µM -0.74688731583244 0.21996091716302 no 2660 0.227565791552771 3777 443158
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.747893401507688 0.219660128238756 no 2661 0.227262228972251 3770 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_524 r073-0010 27.8 µM -0.750730599938206 0.21881316579277 no 2662 0.226407401673607 3708 2772106
SGTC_3084 9116877 49.47 µM -0.751044668746269 0.218719525411315 no 2663 0.226312886778604 3663 27241325
SGTC_453 enantio-paf c16 10 µM -0.751964365218403 0.218445448356248 no 2664 0.226036244398379 3710 13871343 A lipid and platelet activating factor
SGTC_853 0419-0306 21 µM -0.753007722543672 0.218134758966684 no 2665 0.225722636707059 3770 762713
SGTC_2962 9082311 13.18 µM -0.754727096966275 0.217623322271201 no 2666 0.225206372236646 3760 16459453
SGTC_2174 5790901 200 µM -0.755571337099079 0.217372452245941 no 2667 0.224953123221134 3800 786020
SGTC_2930 9013230 14.89 µM -0.756531924404686 0.217087212289723 no 2668 0.224665169640088 3768 2995857
SGTC_3035 9091303 49.47 µM -0.757291226068614 0.216861895875975 no 2669 0.224437703125761 3799 25237002
SGTC_1996 st072960 66.8 µM -0.758996498211775 0.216356363705791 no 2670 0.223927325778275 3740 1719405
SGTC_1808 st050063 61.5 µM -0.759241876490191 0.216283676884372 no 2671 0.223853939901046 3746 4011993
SGTC_559 1550-0661 158 µM -0.759764205975879 0.216128997681887 no 2672 0.223697771079023 3813 5830875
SGTC_1989 st071868 50.2 µM -0.76099073528496 0.215766033348445 no 2673 0.223331300496783 3753 16414057
SGTC_2324 6149169 200 µM -0.761324995441955 0.215667177717564 no 2674 0.223231487298712 3717 2888231
SGTC_2885 9057732 51.95 µM -0.761434432694347 0.215634817949884 no 2675 0.223198813833745 3785 6471414
SGTC_1115 galangin 695.678 nM -0.761795017206227 0.215528215759415 no 2676 0.223091177385493 3808 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1267 0828-0272 9.49 µM -0.761913263524489 0.215493264406701 no 2677 0.223055886649514 3813 745334
SGTC_1306 1185-0270 9.02 µM -0.764722489057348 0.214663878304006 no 2678 0.222218405837267 3795 1548076
SGTC_945 3381-0768 11.3 µM -0.765282209888602 0.214498850164096 no 2679 0.222051757586568 3803 1126236 YIL048W NEO1
SGTC_1743 st037606 46.3785 µM -0.765377827112671 0.214470665751696 no 2680 0.222023296168448 3796 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2219 9098279 200 µM -0.765420529924238 0.214458079241756 no 2681 0.222010585924502 3743 902349
SGTC_3329 9141233 27.5565 µM -0.766461924824802 0.214151264578896 no 2682 0.22170074940243 3765 4909101 YNL103W MET4
SGTC_620 0109-0052 432 µM -0.766558961573499 0.214122688729037 no 2683 0.221671891551184 3743 493037
SGTC_1495 4469-0029 237 µM -0.766633846965415 0.214100637634596 no 2684 0.221649622780479 3783 793680
SGTC_2155 5570423 76 µM -0.766665418541843 0.214091341320086 no 2685 0.221640234681014 3734 797402
SGTC_989 1501-0895 10.3 µM -0.766928902874821 0.21401376698688 no 2686 0.221561894046195 3748 2830112
SGTC_3328 9140624 29.0385 µM -0.767352303297257 0.213889144873667 no 2687 0.221436039421612 3781 4904392
SGTC_3229 9132204 49.47 µM -0.767731817313431 0.21377747604146 no 2688 0.221323264658069 3788 17682924
SGTC_777 1315-0167 517 µM -0.768004868236971 0.2136971540928 no 2689 0.221242146333937 3829 4221767
SGTC_3340 9146634 11.102 µM -0.769501812412109 0.213257118406244 no 2690 0.220797734506394 3808 4907387
SGTC_1548 st061468 90.8 µM -0.769835419252911 0.213159124726377 no 2691 0.220698763221936 3773 390799
SGTC_786 4544-0069 423 µM -0.771490620450863 0.212673314460317 no 2692 0.220208089923905 3833 748821 YLR208W SEC13
SGTC_1046 2001-0062 216 µM -0.771579854397015 0.212647142207315 no 2693 0.220181654902886 3701 739778
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.771849732628826 0.212567998560733 no 2694 0.220101716172723 3824 521171
SGTC_2611 pyromycin 23.93 µM -0.774021784954087 0.211931655997486 no 2695 0.21945895430135 3805 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2967 9089538 49.85 µM -0.774256548688504 0.211862944446643 no 2696 0.219389546771284 3826 728216
SGTC_1699 st031318 29.054 µM -0.774395704723677 0.211822221877216 no 2697 0.219348411462386 3863 5340658
SGTC_1161 k007-0610 110 µM -0.774465072038197 0.211801923963169 no 2698 0.219327907748443 3820 5843850
SGTC_2953 9074162 66.49 µM -0.775250305854059 0.211572232172481 no 2699 0.219095883759832 3724 16451992
SGTC_381 3461-2219 42.7 µM -0.775725308424546 0.211433358144573 no 2700 0.218955596663752 3768 2883159
SGTC_947 3447-0010 211 µM -0.776797024979888 0.211120222127504 no 2701 0.218639266133845 3781 748350
SGTC_1451 4152-0210 104 µM -0.777126213831973 0.211024093743939 no 2702 0.218542154770997 3774 659563
SGTC_905 2-aminofluorene 215 µM -0.777222253685498 0.21099605341377 no 2703 0.218513827504591 3806 1539 An established DNA mutagen. YPR165W RHO1
SGTC_417 st075190 100 µM -0.777249435106238 0.210988117771483 no 2704 0.21850581064024 3791 222757
SGTC_2466 5983409 37.09 µM -0.777293378810186 0.210975288734373 no 2705 0.218492850281052 3810 2879657
SGTC_3052 9092717 49.47 µM -0.77753893387654 0.210903609179651 no 2706 0.218420436635893 3770 25237534
SGTC_467 ro 31-8220 72.8 µM -0.77857077272787 0.210602563000478 no 2707 0.218116300762364 3736 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_968 1309-0633 340 µM -0.780431710450747 0.210060259351428 no 2708 0.217568404422015 3808 3761976
SGTC_1511 0906-3109 28.5 µM -0.781416281845384 0.209773673454924 no 2709 0.217278848999384 3846 2882180
SGTC_1017 4239-0030 168 µM -0.781426422705564 0.209770722882232 no 2710 0.217275867803192 3850 1149593
SGTC_1270 0831-1170 17.3 µM -0.782599846623672 0.20942946963304 no 2711 0.216931065798449 3800 6764716
SGTC_2240 6690706 185.951 µM -0.784468807456248 0.208886616427356 no 2712 0.216382538942712 3715 805876
SGTC_1244 0416-0015 52.5 µM -0.784630582742809 0.208839666639213 no 2713 0.216335096814888 3805 96201
SGTC_687 k029-0044 34.9 µM -0.785171906749115 0.208682610929592 no 2714 0.216176392235573 3829 5829338
SGTC_2569 tetrandrine 100 µM -0.786661726262947 0.208250725422093 no 2715 0.215739957402398 3829 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1866 st057638 64 µM -0.787002641776995 0.20815197122417 no 2716 0.215640159844881 3794 688802
SGTC_1672 st016598 6.51 µM -0.788354870589828 0.207760538639941 no 2717 0.215244580253674 3847 4665860 YNL267W PIK1
SGTC_718 1130-0073 349 µM -0.791008182613651 0.206993743480708 no 2718 0.214469608285524 3856 6740020
SGTC_1289 0976-0073 69.1 µM -0.791756715394479 0.20677772413031 no 2719 0.214251272677349 3882 3391136
SGTC_3068 9116768 49.47 µM -0.792024204508392 0.206700561728814 no 2720 0.214173281548676 3770 41904888
SGTC_1666 st014829 29 µM -0.792521343333962 0.206557197731231 no 2721 0.214028375918668 3834 3858230
SGTC_2271 7849410 118.62 µM -0.792632717573866 0.206525087906178 no 2722 0.213995920469532 3758 972430
SGTC_1623 st003709 20.3 µM -0.79286095220989 0.206459295805058 no 2723 0.213929419807763 3805 16192618
SGTC_795 0685-0265 78 µM -0.792988510685114 0.206422530546719 no 2724 0.213892258372378 3858 302754
SGTC_2064 5220758 200 µM -0.793018658542651 0.206413841814193 no 2725 0.213883475987608 3878 788518
SGTC_2924 9010168 62.78 µM -0.795435809647968 0.205717914675014 no 2726 0.213180018233529 3922 2993929
SGTC_2887 9044784 58.44 µM -0.79567082066477 0.20565032650558 no 2727 0.213111695584651 3822 6465546
SGTC_2504 purpurogallin 52.29 µM -0.796579855724853 0.205389016008816 no 2728 0.212847540244302 3749 5281571 An antioxidant.
SGTC_2829 7992743 58.44 µM -0.796934424523437 0.205287145427412 no 2729 0.212744558380408 3883 16462845
SGTC_3166 9102297 49.47 µM -0.798077835650467 0.204958838378119 no 2730 0.212412661365905 3836 25237072
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.798198034036662 0.204924344017981 no 2731 0.212377789060211 3821 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2732 terfenadine 20 µM -0.799157028416347 0.204649256836336 no 2732 0.212099682662029 3827 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1003 4049-0218 100 µM -0.800315820676207 0.204317150988108 no 2733 0.211763919559706 3839 295161
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.803175399390718 0.203498979763458 no 2734 0.210936681160127 3823 6312947
SGTC_1170 0310-0127 64.8 µM -0.803231259679812 0.203483016726399 no 2735 0.210920540405638 3858 774975
SGTC_2144 5628481 200 µM -0.804217844836598 0.203201206186121 no 2736 0.210635587330419 3830 2818399
SGTC_98 0074-0023 107.663 µM -0.805194455061037 0.202922474478825 no 2737 0.210353737875693 3801 3563821
SGTC_174 3553-0389 74.3 µM -0.809081931052546 0.201815226143694 no 2738 0.209234010414298 3845 738071
SGTC_3356 9151811 4.48 µM -0.809471010354738 0.201704606341567 no 2739 0.209122135607895 3826 1859254 YPR165W RHO1
SGTC_2430 5571206 200 µM -0.809542289643187 0.201684344741699 no 2740 0.209101643972791 3878 1731771
SGTC_1383 3049-0032 20.7 µM -0.810635541430285 0.201373733594846 no 2741 0.208787500045174 3914 712864
SGTC_1336 1486-0901 104 µM -0.81669140967411 0.1996583593137 no 2742 0.207052400850905 3869 5006114
SGTC_1973 st070275 50.2 µM -0.817057294302173 0.19955500192075 no 2743 0.206947843297372 3750 17118334
SGTC_2715 st079500 56.4 µM -0.817497931030778 0.199430570835183 no 2744 0.206821965583942 3797 28246688
SGTC_2374 9071832 200 µM -0.817522412245597 0.199423658972626 no 2745 0.206814973307967 3778 17381698
SGTC_1106 tegaserod maleate 11.7 µM -0.818974183317579 0.199014033530426 no 2746 0.206400571597549 3871 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2988 9073640 71.4286 µM -0.819041867658581 0.1989949483875 no 2747 0.206381263409693 3895 9102229
SGTC_226 1,3-diallylurea 8.28947 mM -0.821601756032599 0.198273939426423 no 2748 0.205651794774122 3829 74537 YKL182W FAS1
SGTC_3086 9117350 49.47 µM -0.821827923339254 0.198210313852976 no 2749 0.205587419549545 3768 2679265
SGTC_1984 st072354 53.1 µM -0.823562828468102 0.197722658921597 no 2750 0.205094002087065 3775 5762938
SGTC_1181 1222-0449 220 µM -0.824278298934365 0.197521762606426 no 2751 0.204890723124935 3883 658318
SGTC_1427 4048-4900 550 nM -0.824661909998421 0.197414099638111 no 2752 0.204781781174719 3869 24132586
SGTC_1398 3558-0053 112 µM -0.825220541684902 0.197257379464069 no 2753 0.204623196634752 3771 4532369
SGTC_2079 5212404 121 µM -0.826341531889732 0.196943120713001 no 2754 0.204305190086381 3807 758462
SGTC_1428 4049-0204 61.7 µM -0.826789689546171 0.196817568904916 no 2755 0.204178137484094 3923 X1428
SGTC_3081 9117243 49.47 µM -0.828362411326833 0.196377352976679 no 2756 0.203732643657168 3903 45595589
SGTC_218 alverine citrate 93.75 µM -0.828506630383199 0.196337014939381 no 2757 0.203691820767013 3904 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1305 1181-0477 144 µM -0.828568661035264 0.196319666524981 no 2758 0.203674263765753 3909 6252086
SGTC_1421 4029-0249 71.4 µM -0.828668785099508 0.196291666301131 no 2759 0.203645926803701 3943 2894095
SGTC_1218 1348-1416 30.7 µM -0.829053420364328 0.196184123533105 no 2760 0.20353708977409 3823 6787668
SGTC_3030 9087619 49.47 µM -0.829338306678561 0.196104493283028 no 2761 0.203456500240977 3911 25236973
SGTC_2345 9052315 157.45 µM -0.830991312566937 0.195642838854574 no 2762 0.202989268538337 3919 6469265
SGTC_577 r071-0003 38.6 µM -0.832182916380169 0.195310455233514 no 2763 0.202652852600372 3908 4568517 YMR134W ERG29
SGTC_3210 9128157 49.47 µM -0.832542739543683 0.195210154350476 no 2764 0.202551332153546 3955 17590849
SGTC_1684 st024538 14.6195 µM -0.835887334576184 0.194279345312265 no 2765 0.201609144125549 3862 6732859
SGTC_2375 9072683 200 µM -0.837689764028632 0.193778847392572 no 2766 0.201102481870618 3902 16798029
SGTC_1842 st055362 61.2 µM -0.838335165109731 0.193599823955712 no 2767 0.200921245703597 3856 676032
SGTC_477 mead ethanolamide 10 µM -0.8389808723205 0.193420816577187 no 2768 0.200740021675102 3747 16061185
SGTC_1882 5615643 20 µM -0.839384144394653 0.193309069973262 no 2769 0.200626889222439 3800 2253075
SGTC_2455 5377712 9.75 µM -0.839415404066226 0.193300409570711 no 2770 0.200618121349007 3890 2243908
SGTC_527 4476-4215 268 µM -0.839986766699965 0.193142156906479 no 2771 0.200457903154831 3881 4418754
SGTC_3063 1327-0034 4 µM -0.840371079051383 0.193035756834818 no 2772 0.200350179759129 3785 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_3112 9123419 49.47 µM -0.842515173293577 0.192442803607808 no 2773 0.199749825074836 3923 17015854
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.845445169089176 0.191634310839442 no 2774 0.198931167114099 3892 75037 A free radical scavenger.
SGTC_2703 st077852 53.4 µM -0.845790337058106 0.191539203567966 no 2775 0.198834858483361 3934 6281836
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.846577265067888 0.191322482268617 no 2776 0.198615395249963 3879 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_976 1348-1067 47.6 µM -0.846914263653672 0.191229718271368 no 2777 0.198521455745591 3933 5310671 YGL099W LSG1
SGTC_1437 4092-1038 11.6 µM -0.850282559984187 0.19030405909824 no 2778 0.197584005150553 3916 3977136
SGTC_1417 3966-0327 90.4 µM -0.852508638044544 0.189693812171702 no 2779 0.196965923372442 3973 651118
SGTC_2891 9063876 19.48 µM -0.852576550074958 0.189675214016052 no 2780 0.196947085671581 3899 6472478
SGTC_2480 5767542 37.17 µM -0.853718176429671 0.189362740063074 no 2781 0.196630580243438 3881 2867358
SGTC_100 0086-0128 49.5915 µM -0.854347352319691 0.189190664171579 no 2782 0.196456278782715 3968 93297
SGTC_2593 nobiletin 86.24 µM -0.855135007204275 0.188975380975398 no 2783 0.196238205700127 3923 72344 An anti-infammatory.
SGTC_3310 9130229 44.1445 µM -0.856611867121415 0.18857213002957 no 2784 0.19582971252481 3992 7761258
SGTC_1085 doxorubicin 7.67 µM -0.857069121806828 0.18844738603008 no 2785 0.195703342515915 3921 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1596 piperlongumine 63 µM -0.857214227312643 0.188407810326712 no 2786 0.195663250522634 3946 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_294 k038-0071 157 µM -0.85749094221439 0.188332354024807 no 2787 0.195586809272076 3914 24152826
SGTC_1822 st052468 42 µM -0.859354684298507 0.187824623261938 no 2788 0.195072431384929 3927 2873678
SGTC_2556 citropten 84.59 µM -0.860141328596299 0.187610575275507 no 2789 0.194855570879066 3964 2775 A potential DNA crosslinker.
SGTC_2472 5377652 49.4 µM -0.860678125070221 0.187464598089352 no 2790 0.194707672112269 4003 1610903
SGTC_685 1278-0033 54.9 µM -0.862852435741845 0.186874031349384 no 2791 0.194109302479768 3934 3590572
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.862952845205387 0.186846786872636 no 2792 0.194081696913068 3912 688669
SGTC_1995 st072814 61.1 µM -0.863866535705472 0.186598984767224 no 2793 0.193830605968136 3914 5769371
SGTC_956 1185-0240 191 µM -0.864898450157255 0.186319363949733 no 2794 0.193547264164493 3921 1416193
SGTC_3257 9139206 32.98 µM -0.865095425034194 0.186266018624465 no 2795 0.193493207771964 3943 4910041
SGTC_3145 9085516 49.47 µM -0.865478721163291 0.186162240349824 no 2796 0.193388045092516 3989 25236195
SGTC_283 0987-0079 11.7 µM -0.866391488905559 0.185915250779814 no 2797 0.193137754875247 3935 411556
SGTC_330 1488-0319 80.1 µM -0.869687308319775 0.185025114160419 no 2798 0.192235654985355 3977 6846614
SGTC_2117 5521686 200 µM -0.869872140696004 0.184975273070351 no 2799 0.19218514088957 3883 803312
SGTC_1293 1000-1278 195 µM -0.871999245427854 0.184402287884455 no 2800 0.191604394599321 3985 678847
SGTC_1799 st045822 46.1415 µM -0.873093864315757 0.184107857583565 no 2801 0.191305958975565 3869 3674992
SGTC_3294 9122953 26.2835 µM -0.875333646141151 0.183506314299355 no 2802 0.190696196002244 3938 16459826
SGTC_1573 oleylamine 1.06 µM -0.880341229121696 0.182165853876961 no 2803 0.189337241978937 3946 5356789 An amine of the fatty acid oleic acid.
SGTC_2940 9060638 45.86 µM -0.88043007910899 0.182142125364175 no 2804 0.189313183886391 3951 4027022
SGTC_3209 9113616 49.47 µM -0.881056039109933 0.181975009587615 no 2805 0.189143744752906 3958 16649353
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.881931386343769 0.18174147445728 no 2806 0.188906956445757 3953 616764
SGTC_2176 5809774 33.9695 µM -0.882055212730234 0.181708453784531 no 2807 0.188873475186678 3919 2870539
SGTC_2116 5511452 16.8835 µM -0.88217136194494 0.181677483788437 no 2808 0.18884207307194 3997 870744
SGTC_2973 9094665 17.96 µM -0.884994219133867 0.180925813689569 no 2809 0.188079874619016 4020 25237061 YIL048W NEO1
SGTC_1714 st033236 13.627 µM -0.885257871552855 0.180855708009371 no 2810 0.18800878302878 3971 2916566
SGTC_3188 9110789 49.47 µM -0.885432453954623 0.180809295587706 no 2811 0.187961717527086 3935 849217
SGTC_2638 epoxomicin 18 µM -0.885470097763289 0.180799289026573 no 2812 0.187951570122347 3953 9915668 A protesome inhibitor.
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.885521435865081 0.180785642777487 no 2813 0.187937731778321 3905 2333 A French combination drug.
SGTC_18 0111-0177 500 nM -0.885649674426298 0.180751558335965 no 2814 0.187903167426122 3996 721752
SGTC_757 1066-0008 322 µM -0.886373967926204 0.18055912449383 no 2815 0.18770802109653 3983 6842497
SGTC_1998 st075797 76.8 µM -0.888267799829846 0.180056569470002 no 2816 0.187198358068849 3887 24208315
SGTC_1477 0139-0234 16 µM -0.889270525029869 0.17979083812709 no 2817 0.186928854153529 3968 620880
SGTC_1514 1189-1591 158 µM -0.890922088913428 0.179353695974166 no 2818 0.186485484589949 4010 767698 YMR146C TIF34
SGTC_190 3970-0790 3.722 µM -0.894357110769403 0.178446644039592 no 2819 0.185565426134405 3870 2832352
SGTC_2253 7938677 135.83 µM -0.895608195558499 0.178117001749629 no 2820 0.185231028514288 4048 2301972
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.897307028727063 0.177669999370902 no 2821 0.184777553469075 3963 688662
SGTC_3019 9081971 49.47 µM -0.900019972788686 0.176957630106379 no 2822 0.184054810930056 4004 16451803
SGTC_2810 7959871 45.46 µM -0.900289980338161 0.176886829974998 no 2823 0.18398297592485 3948 2974535
SGTC_568 1193-0097 7.48 µM -0.900689089852238 0.176782210117765 no 2824 0.183876825561118 3834 3646150
SGTC_1929 genistein trimethyl ether 50.5 µM -0.900889561521607 0.176729674597345 no 2825 0.183823520904225 3927 136420
SGTC_1322 1348-1070 12 µM -0.901853319708594 0.17647725034225 no 2826 0.183567395638938 3922 6758089
SGTC_3339 9145883 14.936 µM -0.902734955581788 0.176246535123382 no 2827 0.18333328981927 3894 2030670
SGTC_1839 st053978 48 µM -0.903688477409531 0.175997223040276 no 2828 0.183080305356613 3975 3788398
SGTC_1526 st051518 75 µM -0.903725192909726 0.175987627708093 no 2829 0.183070568508534 3985 673993
SGTC_2236 dapsone 200 µM -0.90661205563596 0.175234203988246 no 2830 0.182305992139499 3974 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1189 1431-2119 7.28 µM -0.907060012461793 0.175117478215538 no 2831 0.182187531289546 3994 3107275
SGTC_1881 5652484 16 µM -0.907159621269398 0.175091529483203 no 2832 0.182161196576746 3948 2255129
SGTC_1851 st056236 18.9 µM -0.907359821371058 0.175039383452666 no 2833 0.18210827459745 3936 5393171
SGTC_2211 7117706 200 µM -0.908670125936736 0.174698332323738 no 2834 0.18176213895096 3917 822771
SGTC_2232 chlorophetanol 41.5365 µM -0.908727323057091 0.174683454452717 no 2835 0.181747038896741 4043 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_11 0438-0307 1.3 µM -0.90900532179983 0.17461115406242 no 2836 0.181673658335936 3957 4011476
SGTC_2297 7971671 152.32 µM -0.910765942133334 0.174153702911816 no 2837 0.181209355500883 4004 909016
SGTC_2266 7929956 200 µM -0.912150739214612 0.173794435281779 no 2838 0.180844685733902 3943 2967153
SGTC_2641 levomentholum 100 µM -0.912491939008453 0.173705987859197 no 2839 0.180754905524613 3955 16666
SGTC_29 0299-0004 12.984 µM -0.913084213473186 0.173552523683993 no 2840 0.180599126175288 3873 16871 A napthoquinone isolated from Swertia calycina.
SGTC_265 mycophenolic acid 32.932 µM -0.914648072124144 0.17314772725523 no 2841 0.180188206677199 4062 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2479 5617353 43.85 µM -0.915194903576358 0.173006324874533 no 2842 0.180044659832761 4041 2731746
SGTC_1959 st077091 55.8 µM -0.916293254144547 0.172722530310611 no 2843 0.179756552613582 3973 821356 YKL052C ASK1
SGTC_688 0527-0193 473 µM -0.916307491224981 0.172718853647501 no 2844 0.179752820002019 4012 4007154
SGTC_2844 9010103 25.97 µM -0.918502947006841 0.172152483978959 no 2845 0.179177808400926 4042 2480525
SGTC_1868 st057644 42.7 µM -0.919007020963982 0.172022613694324 no 2846 0.179045949937241 4001 688665
SGTC_1458 k015-0034 6.33 µM -0.919636551839871 0.171860508375692 no 2847 0.178881359516176 4020 3598957
SGTC_2458 5808907 16.39 µM -0.924020651049676 0.170734301489533 no 2848 0.177737781977222 4138 2731747
SGTC_1434 4073-0095 163 µM -0.925790658826197 0.170280955587178 no 2849 0.177277391297979 3934 24133745
SGTC_3169 9102970 49.47 µM -0.926330374353912 0.170142873701605 no 2850 0.177137157694954 4053 17027839
SGTC_3160 9100216 49.47 µM -0.927871017170722 0.169749107480582 no 2851 0.176737240055441 3904 17191039
SGTC_1480 1070-0044 41.2 µM -0.929392685350166 0.169360765074444 no 2852 0.176342808592221 4013 3124987
SGTC_352 k048-0007 5.11 µM -0.932474495969599 0.168576009720165 no 2853 0.175545680562366 4003 6811911
SGTC_2684 capsaicin 100 µM -0.932581619529231 0.168548773774964 no 2854 0.175518013569521 4038 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_129 0088-0017 176.636 µM -0.932868357013151 0.168475885279428 no 2855 0.175443970968171 3848 182446
SGTC_2424 5537928 59.2 µM -0.935148638034718 0.167896960827166 no 2856 0.17485585187203 4046 5382802
SGTC_1216 1165-0504 9.65 µM -0.939087374142361 0.166900003123171 no 2857 0.173842943067192 4061 6304004
SGTC_3095 9117207 49.47 µM -0.941391980434698 0.166318444501135 no 2858 0.173252010890438 3999 17015229
SGTC_2772 vinpocetine 57.06 µM -0.943048738628041 0.165901177402452 no 2859 0.172827986945567 4037 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2733 amorolfine 100 µM -0.945204678100394 0.165359201744215 no 2860 0.172277195804691 4113 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_435 c-PAF 6.7 µM -0.948062542585525 0.164642538947111 no 2861 0.171548807875009 4031 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_1540 guanosine 70.6 µM -0.948473500912139 0.164539649240752 no 2862 0.171444228415577 3911 6802 Guanosine is a purine nucleoside
SGTC_1730 st033808 45.1 µM -0.950719531405143 0.163978057550048 no 2863 0.170873385318221 3985 1045166
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.954421549700441 0.163055131931507 no 2864 0.169935151180464 4080 5282362
SGTC_1784 st039334 36.3 µM -0.958544626560926 0.16203121724464 no 2865 0.168894099791948 4126 3496984
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.961639091407371 0.16126550256154 no 2866 0.168115463918942 3846 88881 An O-methylated flavonoid and antioxidant.
SGTC_507 nimesulide 162 µM -0.962163761547571 0.161135909157599 no 2867 0.167983674669761 4105 4495 A COX2 inhibitor.
SGTC_731 3966-0296 387 µM -0.967533976826055 0.159813375560187 no 2868 0.166638582268608 4045 660956
SGTC_2016 5121758 140 µM -0.969528865447393 0.159323904380665 no 2869 0.166140692652267 3986 2795203
SGTC_1571 st070080 73.4 µM -0.969747167911579 0.159270400760041 no 2870 0.166086266538207 4093 4315245
SGTC_585 0kpi-0023 191 µM -0.970540631492678 0.159076030364992 no 2871 0.165888541075894 3992 64601
SGTC_1153 4055-0057 267 µM -0.973301728743251 0.158400871391092 no 2872 0.165201681758355 4103 882706
SGTC_715 0868-0130 184 µM -0.974317177379935 0.158153041689181 no 2873 0.164949539148506 4109 2876258
SGTC_2861 9024595 19.48 µM -0.976410070092074 0.157643054934462 no 2874 0.16443064660344 3959 16482810
SGTC_2644 guaiazulene 100 µM -0.976673085836372 0.157579040937329 no 2875 0.164365511825198 4063 3515 A coloring agent.
SGTC_1416 3966-0321 25.3 µM -0.977658882226509 0.157339265215716 no 2876 0.164121532224721 4089 582530 YLR208W SEC13
SGTC_882 0843-0131 351 µM -0.978312005365529 0.157180537925628 no 2877 0.163960017003433 4052 5425421
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.978694351315563 0.157087665987879 no 2878 0.163865511973616 4145 4213774
SGTC_3174 9107204 49.47 µM -0.978918358843633 0.157033271266753 no 2879 0.163810160117925 4106 3938802
SGTC_2958 9077254 16.72 µM -0.97955829413368 0.156877946972738 no 2880 0.163652100122631 4147 16457351
SGTC_2381 9035592 200 µM -0.980215138249588 0.156718623752638 no 2881 0.163489966763415 4062 4749657
SGTC_189 3970-0742 2.116 µM -0.980795314780463 0.156577985525119 no 2882 0.163346844588224 3988 2891807
SGTC_2442 5158906 48.48 µM -0.982557799181219 0.156151258617388 no 2883 0.162912561449463 4090 1893835
SGTC_2453 5731132 22.18 µM -0.985357149593811 0.155475065670509 no 2884 0.162224334966271 4117 1362040
SGTC_2745 rifampicin 24.3 µM -0.98950195950371 0.154477425290323 no 2885 0.161208805809107 4090 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2519 cryptotanshinone 88.04 µM -0.991597986182126 0.153974534080767 no 2886 0.160696836022577 4063 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1098 clofazimine 15.1 µM -0.992414695167066 0.153778878003541 no 2887 0.160497636687295 4140 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1133 3473-0247 50 µM -0.992663946173882 0.153719198614586 no 2888 0.160436875284591 4068 711311
SGTC_746 1095-0025 46.6 µM -0.995140614668252 0.15312703093689 no 2889 0.159833939812715 4089 6749286
SGTC_2834 9001755 58.44 µM -0.99526655124985 0.153096960139975 no 2890 0.159803320686892 4005 2989575
SGTC_1338 1486-1223 76 µM -0.996057168122987 0.152908268199813 no 2891 0.159611184641669 4105 3444526
SGTC_449 xestospongin c 11.1929 µM -0.998156835024966 0.152407901730217 no 2892 0.159101656914026 4107 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2919 7978188 46.38 µM -0.999742962579254 0.152030636896883 no 2893 0.158717457455673 4104 2980291
SGTC_384 k007-0144 5.16 µM -1.00046100509062 0.151860052621962 no 2894 0.158543729908171 4042 6824886
SGTC_1876 myriocin 605 nM -1.00080413281672 0.151778581207678 no 2895 0.158460755563892 4095 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1351 1496-0003 46.5 µM -1.00099923537158 0.151732269485557 no 2896 0.158413589025025 4104 3891978
SGTC_1130 3454-2858 15.9 µM -1.00238935949668 0.151402565943337 no 2897 0.158077789592381 4129 715628 YIL048W NEO1
SGTC_2120 5538279 151.968 µM -1.00372470574553 0.151086303324995 no 2898 0.157755662662016 4057 2058197
SGTC_444 curcumin 90.4 µM -1.00522512436237 0.150731469877756 no 2899 0.157394229922016 4043 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_716 1683-5115 658 µM -1.00527870361695 0.150718809208872 no 2900 0.157381333399362 4020 723597
SGTC_850 0388-0143 75.9 µM -1.00549135931023 0.150668566083727 no 2901 0.157330154039125 4056 67273
SGTC_1344 1488-0097 29.1 µM -1.00676713831478 0.150367378180919 no 2902 0.157023344951435 4129 747966
SGTC_287 k060-0039 29.6 µM -1.01299328528718 0.148903259057155 no 2903 0.155531684113161 4155 5861974
SGTC_3180 9109287 49.47 µM -1.01472362555492 0.148498055455148 no 2904 0.155118794473405 4141 18891271
SGTC_2948 9070189 9.45 µM -1.01616334680892 0.148161470253326 no 2905 0.154775803704876 4052 6473636 YDL196W YDL196W
SGTC_1026 k007-1105 30.6 µM -1.01711594386515 0.147939048205862 no 2906 0.154549138200454 4092 7066794
SGTC_1093 fluphenazine 7.97 µM -1.01725386680415 0.147906863089163 no 2907 0.154516338347994 4111 6602611 An atypical antipsychotic.
SGTC_899 1083-0020 478 µM -1.01729814040534 0.147896532581825 no 2908 0.154505810490671 4172 767123
SGTC_2477 5967686 25.23 µM -1.01831240534925 0.147660003039683 no 2909 0.154264757420478 4092 776118
SGTC_3314 9135860 59.4275 µM -1.01995579429224 0.14727729804613 no 2910 0.153874713194834 4114 25252478
SGTC_1370 2001-0092 44.6 µM -1.02042689844547 0.147167712155998 no 2911 0.15376302115081 4175 790957
SGTC_2166 5933061 31.504 µM -1.02156632702985 0.146902890025988 no 2912 0.153493100885576 4235 2877375
SGTC_1157 4092-0394 27.6 µM -1.02161853760769 0.146890763083745 no 2913 0.15348074019858 4208 3659885
SGTC_2761 levamisole 97.89 µM -1.02279611653701 0.146617425382595 no 2914 0.153202127284279 4081 26879 An alkaline phosphatase inhibitor.
SGTC_1507 4075-3230 155 µM -1.02361407081024 0.146427764189683 no 2915 0.153008798251459 4007 659771
SGTC_326 k292-0812 17.5 µM -1.02425792329672 0.146278588333755 no 2916 0.152856733162472 4099 3579357
SGTC_2310 7668677 200 µM -1.02578597009641 0.145924959841423 no 2917 0.152496240330322 4140 2197143
SGTC_2987 9018338 71.43 µM -1.02930930889293 0.145111761564661 no 2918 0.151667175163716 4150 5055682
SGTC_3125 9127534 49.47 µM -1.02945295410818 0.145078672605826 no 2919 0.151633438162756 4015 1639235
SGTC_378 3970-0959 8.33 µM -1.03212189715583 0.144464800023759 no 2920 0.151007508542142 4153 6615653
SGTC_1304 1165-0502 251 µM -1.03474277517871 0.143863688325121 no 2921 0.15039452692117 4128 767425
SGTC_2421 5690543 90.72 µM -1.03502420707798 0.143799240954755 no 2922 0.150328803191375 4141 3397993
SGTC_548 1436-0017 110 µM -1.03575259452912 0.143632532069685 no 2923 0.150158789322073 4195 9677137
SGTC_694 1315-0438 43.2 µM -1.03673784876633 0.143407240699657 no 2924 0.149929023848909 4112 6793154
SGTC_2428 5615643 7.78 µM -1.03957030474506 0.142760891790378 no 2925 0.149269789555152 4170 2253075
SGTC_643 k048-0106 28.4 µM -1.04040482361236 0.142570835916691 no 2926 0.149075930814225 4135 6763920
SGTC_2938 9059746 27.26 µM -1.04344857859993 0.141879092472981 no 2927 0.148370292290681 4137 6471769
SGTC_979 1426-2828 121 µM -1.0438186498793 0.141795142899227 no 2928 0.148284650656893 4239 747872
SGTC_1870 st057514 26.5 µM -1.04617148836854 0.141262195365937 no 2929 0.147740932027979 4129 5393161
SGTC_2893 9048488 25.97 µM -1.05138311486457 0.140086536794636 no 2930 0.146541333836749 4200 6467338
SGTC_644 1498-1197 63.3 µM -1.05491869712275 0.139292761743162 no 2931 0.145731255151396 4181 6741615
SGTC_1307 1187-1599 12.2 µM -1.05909852938864 0.138358300532453 no 2932 0.144777454828072 4134 1538471
SGTC_1143 3454-2408 5.08 µM -1.05970800741945 0.138222400800325 no 2933 0.144638729387815 4139 X1143
SGTC_756 0508-1999 28.3 µM -1.06104425235665 0.137924767160597 no 2934 0.144334895423816 4157 6753853
SGTC_1920 st075728 45.7 µM -1.06213664674061 0.137681773529492 no 2935 0.144086827751694 4136 3400306
SGTC_2903 5923464 63.88 µM -1.06243825100952 0.137614735781736 no 2936 0.144018388265233 4162 2876576
SGTC_2705 st078069 42.8 µM -1.0644762737647 0.137162327275168 no 2937 0.14355649853005 4212 1530061
SGTC_1825 st052143 62.6 µM -1.06493256774759 0.137061176656819 no 2938 0.143453222943035 4215 674173
SGTC_778 3456-2434 196 µM -1.06586698236444 0.13685419600216 no 2939 0.143241888189412 4121 5539063
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.06594433652312 0.136837070989136 no 2940 0.143224402577446 4194 6708760
SGTC_250 brefeldin a 552.239 µM -1.06630690763319 0.136756822882249 no 2941 0.143142463979005 4027 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1396 3511-0007 98.6 µM -1.06758073574955 0.136475140762539 no 2942 0.142854838611136 4171 X1396
SGTC_3353 9151644 39.2805 µM -1.0703420436749 0.13586589491683 no 2943 0.142232688115273 4197 4909158
SGTC_1008 4106-0037 6 µM -1.07059875637571 0.13580934944428 no 2944 0.142174941450641 4131 2905394
SGTC_3066 9117245 49.47 µM -1.0707665047496 0.135772408631976 no 2945 0.142137215586851 4232 17176980
SGTC_1137 ixabepilone 100 µM -1.07115978729277 0.135685828654643 no 2946 0.142048794654706 4122 154225 A novel microtubule stabilizer.
SGTC_2259 7964009 200 µM -1.07221407915544 0.135453916062223 no 2947 0.141811944038135 4210 313134
SGTC_2154 5570129 200 µM -1.07304459868737 0.135271418050145 no 2948 0.141625553140466 4207 673366
SGTC_669 0108-0021 26.2 µM -1.07906430741436 0.133953688615423 no 2949 0.140279530588136 4067 17201
SGTC_2044 5102272 200 µM -1.07921961484582 0.133919808558448 no 2950 0.140244918798597 4172 592666
SGTC_1787 fluconazole 80 µM -1.0803586157281 0.133671517382243 no 2951 0.139991258504494 3952 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_627 1391-0720 175 µM -1.08093032223714 0.133547010269359 no 2952 0.139864054644218 4156 997839
SGTC_809 3998-0021 90 µM -1.08114247342728 0.133500827955846 no 2953 0.139816871307157 4131 715485
SGTC_606 k015-0008 38.6 µM -1.08274596353175 0.133152126090327 no 2954 0.139460598166028 4260 1970475
SGTC_645 0845-0943 5.41 µM -1.08284333493733 0.133130971491032 no 2955 0.13943898350294 4185 1885106
SGTC_2201 6605497 169.863 µM -1.08552943251316 0.132548310456419 no 2956 0.138843617607894 4109 670741
SGTC_2048 5246248 200 µM -1.08640359161745 0.132359069713696 no 2957 0.13865023662641 4202 677046
SGTC_569 4130-2812 160 µM -1.08710269787895 0.132207859039281 no 2958 0.138495712843117 3994 743552
SGTC_1118 chelidonine 707.474 nM -1.09087082922476 0.131394895720282 no 2959 0.137664862252094 4177 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2475 5812728 15.03 µM -1.09109108258279 0.131347483703371 no 2960 0.137616403146662 4114 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_406 estrone 100 µM -1.09201206640261 0.131149359537091 no 2961 0.137413898765494 4177 5870 A steroid.
SGTC_2545 solidagenone 89.61 µM -1.09206927775044 0.131137058913378 no 2962 0.137401325945767 4031 6708572 An anti ulcer agent
SGTC_1676 st018489 23.4 µM -1.09327940194341 0.130877065008633 no 2963 0.137135571925717 4210 3696235
SGTC_516 3992-2719 87.3 µM -1.09368909702274 0.130789123226106 no 2964 0.137045678865835 4109 5350887 YDR037W KRS1
SGTC_1259 0671-0132 43 µM -1.09481029927269 0.130548664023998 no 2965 0.136799876676958 4119 X1259
SGTC_3271 9137798 49.47 µM -1.09732936727604 0.130009526366344 no 2966 0.136248718824073 4132 6498326
SGTC_258 haloperidol 50.781 µM -1.09775271170366 0.129919072544469 no 2967 0.13615624280117 4177 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2512 diallyl trisulfide 49.23 µM -1.09791149517173 0.129885157337025 no 2968 0.136121568970559 4214 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2860 9025725 38.96 µM -1.09949444848035 0.129547383038947 no 2969 0.135776227070068 4230 40546248
SGTC_1632 st005650 90 µM -1.10361102584974 0.128671828763193 no 2970 0.134880953118463 4222 2759605
SGTC_2377 9073351 62.6 µM -1.10429575322496 0.128526593419423 no 2971 0.134732432217645 4163 7337946 YHR072W ERG7
SGTC_3010 9080089 71.4286 µM -1.10818967902133 0.127702828684256 no 2972 0.133889953614921 4221 17027233
SGTC_519 k048-0011 62.8 µM -1.10895570529268 0.127541207859142 no 2973 0.13372464547756 4243 6836379
SGTC_1144 3486-0183 12.5 µM -1.11234265585093 0.126828313548051 no 2974 0.132995425067204 4195 6744069
SGTC_1251 0490-5699 265 µM -1.11334708668515 0.126617432663564 no 2975 0.132779695428932 4256 3883818
SGTC_1758 st042942 75.2445 µM -1.11437388090938 0.126402109125912 no 2976 0.132559411849739 4175 669317
SGTC_356 1634-0012 32.5 µM -1.11659174452278 0.125937883847427 no 2977 0.132084461515366 4218 735457
SGTC_3282 9108498 15.4605 µM -1.11772155871812 0.125701857915561 no 2978 0.131842966107674 4182 16459645
SGTC_2965 9082772 38.63 µM -1.11993642791606 0.125240052441752 no 2979 0.131370426774632 4229 16459634
SGTC_3148 9097893 49.47 µM -1.12152748461739 0.124909045326167 no 2980 0.131031699561846 4189 17174100
SGTC_542 3381-0244 89.3 µM -1.12171811829249 0.124869426496628 no 2981 0.130991155218691 4228 1112843
SGTC_160 3453-0671 289.699 µM -1.12249809857104 0.124707416971747 no 2982 0.13082535777819 4252 5322268
SGTC_679 0422-0091 41.4 µM -1.12304078373106 0.124594782661085 no 2983 0.130710086856677 4233 627384 YHR062C RPP1
SGTC_1660 st012960 28.1 µM -1.12324238374063 0.12455295869812 no 2984 0.130667283199699 4230 24207266
SGTC_1407 3909-7909 12.3 µM -1.12387328208498 0.124422135871595 no 2985 0.130533393661752 4211 4411780
SGTC_2336 9001819 198.65 µM -1.12439611435545 0.124313794412317 no 2986 0.130422509866204 4290 2989602
SGTC_2544 sphondin 68.51 µM -1.12601879993076 0.12397796125717 no 2987 0.130078780918735 4208 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_23 0213-0011 39.996 µM -1.12691906898069 0.123791914463338 no 2988 0.129888350093073 4224 627608
SGTC_2195 6536160 144.242 µM -1.12759193247087 0.123652990282155 no 2989 0.129746147683634 4190 3834386
SGTC_1884 5633444 25 µM -1.12957683735335 0.123243808863831 no 2990 0.129327287812051 4208 5724239
SGTC_3285 9112818 20.8695 µM -1.1302122907308 0.123113013032135 no 2991 0.129193391014876 4203 17017947 YPR165W RHO1
SGTC_1917 st066507 28.5 µM -1.13101794363643 0.122947324822081 no 2992 0.129023769560655 4178 3156428
SGTC_2241 6772625 37.8075 µM -1.13123457813062 0.122902799092123 no 2993 0.128978185881775 4062 2285411
SGTC_2864 9034755 47.6 µM -1.13346088756041 0.122445872151976 no 2994 0.128510378627939 4151 4930451
SGTC_851 0394-0702 453 µM -1.13877396162214 0.121360239815714 no 2995 0.127398722406499 4226 762646
SGTC_1030 k029-0042 36.7 µM -1.1423086020337 0.120641758383184 no 2996 0.126662883464152 4211 6080581
SGTC_3155 9099265 49.47 µM -1.14274772064404 0.120552708920402 no 2997 0.126571675179894 4236 25236499
SGTC_738 1315-0003 72.4 µM -1.14358382375417 0.120383282413468 no 2998 0.126398136688479 4266 6251474
SGTC_558 k064-0027 21.3 µM -1.14376948100892 0.120345683911282 no 2999 0.12635962485404 4238 5088526
SGTC_2078 5212016 200 µM -1.14398842283015 0.120301355393188 no 3000 0.126314219139088 4105 1899708
SGTC_2794 7785382 27.27 µM -1.14411568187233 0.120275594909148 no 3001 0.126287832477778 4222 2205081
SGTC_2359 9039622 200 µM -1.14464614781941 0.120168256900105 no 3002 0.126177883832347 4187 6463596
SGTC_1607 st000305 50.6 µM -1.14533478906756 0.120029013362691 no 3003 0.126035250056516 4255 5457690
SGTC_1053 3366-3204 134 µM -1.14661541689193 0.119770372360407 no 3004 0.125770300953267 4253 3632071 YPR165W RHO1
SGTC_354 2783-3500 4.88 µM -1.14872840040771 0.11934448490044 no 3005 0.125333995605521 4255 6740761
SGTC_779 1360-0071 233 µM -1.15112981398732 0.118861760998968 no 3006 0.1248394170965 4285 7566
SGTC_2158 5657123 3.6195 µM -1.15156346519687 0.118774737131346 no 3007 0.124750250858209 4212 2858827
SGTC_2370 9071495 200 µM -1.15160403804971 0.118766597391916 no 3008 0.124741910650742 4247 21791103
SGTC_1183 1254-0324 198 µM -1.15239564104992 0.11860786457096 no 3009 0.12457926569102 4318 5799357
SGTC_2070 5230947 200 µM -1.15525757409045 0.118035238514313 no 3010 0.123992482017194 4346 2835538
SGTC_248 streptozotocin 5.23457 mM -1.15617407335318 0.117852276038531 no 3011 0.12380498119906 4272 5300 DNA alkylating agent.
SGTC_199 4063-0024 41.6 µM -1.15866083483967 0.117356850345155 no 3012 0.123297230535219 4258 306215
SGTC_3202 9113761 49.47 µM -1.16196476013238 0.116700909135322 no 3013 0.122624889803324 4220 4798415
SGTC_928 2764-0428 58.7 µM -1.16397269587984 0.116303538019868 no 3014 0.122217538536416 4273 662578
SGTC_253 dyclonine 31.25 µM -1.16405798682148 0.116286680197441 no 3015 0.122200256564642 4356 3180 An oral anasthetic.
SGTC_60 0986-0278 202 µM -1.16630462025748 0.115843255490441 no 3016 0.121745652918934 4210 3110598
SGTC_3304 9125678 46.087 µM -1.16759399919811 0.115589309901285 no 3017 0.121485285941852 4182 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_812 4251-0442 148 µM -1.1680791604437 0.115493858966643 no 3018 0.121387417746052 4283 5723007
SGTC_1910 st062352 60.4 µM -1.16870769063566 0.115370284829444 no 3019 0.121260711176227 4151 2245730
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -1.17100286657969 0.114919832789897 no 3020 0.120798812456874 4306 6710655
SGTC_1403 3909-7815 62.9 µM -1.17112325997232 0.114896238919071 no 3021 0.120774617801152 4220 6615483
SGTC_2617 dihydrotanshinone i 20.83 µM -1.17155658953731 0.114811346484641 no 3022 0.120687562686606 4226 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_861 0443-0273 110 µM -1.17271256071195 0.114585101589262 no 3023 0.120455546330415 4259 6149169
SGTC_528 3492-0019 172 µM -1.1734270202605 0.114445427427068 no 3024 0.120312303473649 4258 2869262
SGTC_967 1306-0166 352 µM -1.17583476580873 0.113975614803807 no 3025 0.119830455420176 4272 4437607
SGTC_1833 st055984 71 µM -1.18005682067805 0.113155104636996 no 3026 0.118988808296723 4267 676288
SGTC_2719 novobiocin 32.65 µM -1.18231766792282 0.112717470429447 no 3027 0.118539838863938 4304 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2096 5468907 200 µM -1.18304330278253 0.112577265189558 no 3028 0.118395993069968 4273 759785
SGTC_38 0929-0051 58.268 µM -1.1899073988078 0.111257162097144 no 3029 0.117041395058276 4260 1379719
SGTC_1404 3909-7820 48.3 µM -1.19296643663139 0.110672431649367 no 3030 0.116441259011176 4249 23741373
SGTC_1113 artemisinin 1.17947 µM -1.19341564787826 0.110586751397626 no 3031 0.116353314830844 4320 2240 An anti-malaria and mitochondrial poison.
SGTC_440 fluspirilene 35.1 µM -1.19918881870195 0.109489836161706 no 3032 0.115227266991862 4351 3396 An atypical antipsychotic.
SGTC_74 000s-0487 160.283 µM -1.19965483656208 0.109401633776291 no 3033 0.115136710029568 4164 677548
SGTC_1001 4048-4355 44.4 µM -1.20255872222762 0.108853170123377 no 3034 0.114573564615912 4271 21824233
SGTC_3352 9151559 45.5865 µM -1.20731354707809 0.10795938874801 no 3035 0.113655707723677 4282 17159339
SGTC_262 fenpropimorph 62.5 µM -1.20759568852159 0.107906520199536 no 3036 0.113601409220585 4288 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_492 tmb-8 126 µM -1.20911943275747 0.107621318473743 no 3037 0.113308482226194 4264 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_280 3448-3607 3.04 µM -1.20933987374646 0.107580103183354 no 3038 0.113266148955165 4254 626179
SGTC_1921 5740136 50 µM -1.21023341416724 0.107413156695175 no 3039 0.11309466988959 4239 1774243
SGTC_1955 wogonin 32.4 µM -1.21041012499191 0.107380162688584 no 3040 0.113060779322726 4345 5281703 A flavanone.
SGTC_1388 3346-4487 254 µM -1.21685611834636 0.106181608777756 no 3041 0.111829481983392 4366 3345614
SGTC_3102 9121669 49.47 µM -1.21851836137164 0.105874108268642 no 3042 0.111513525780783 4346 41905072
SGTC_896 0964-0007 44.5 µM -1.21873115231358 0.105834790312074 no 3043 0.111473125024319 4272 6756758
SGTC_1954 st077032 68.9 µM -1.2201668382829 0.105569790533697 no 3044 0.111200817611053 4257 698907
SGTC_3345 9148410 3.559 µM -1.22126975589028 0.10536653947408 no 3045 0.110991950288717 4241 4903596
SGTC_175 3793-3120 23.7 µM -1.22180185519736 0.10526858289825 no 3046 0.110891283418588 4301 5322297
SGTC_1675 st018485 24.5 µM -1.22345448160027 0.104964763560503 no 3047 0.110579043218166 4336 3323024
SGTC_2636 apigenin dimethyl ether 100 µM -1.22607362336314 0.104484560769935 no 3048 0.110085485361577 4301 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_803 4488-1585 147 µM -1.22949229247115 0.10386016717495 no 3049 0.109443642941065 4303 747204
SGTC_1946 st076057 65.1 µM -1.22987873478145 0.103789757077878 no 3050 0.109371259262933 4252 953009
SGTC_2691 st077356 60.2 µM -1.23070960168172 0.103638489735493 no 3051 0.109215747834251 4328 2839272
SGTC_2129 girgensonine 121.053 µM -1.2315089069108 0.103493119529128 no 3052 0.109066293727239 4328 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1738 st035555 74 µM -1.23409081116927 0.103024557979167 no 3053 0.108584533587259 4354 5331140
SGTC_3029 9088683 49.47 µM -1.23466244707611 0.102921026708856 no 3054 0.108478078742234 4341 25236615
SGTC_844 0330-0132 15.3 µM -1.23577338980529 0.102720035652422 no 3055 0.108271404451314 4360 2828079
SGTC_53 0973-0023 39.979 µM -1.23915382786828 0.102110203853722 no 3056 0.107644267956078 4210 674768
SGTC_2994 9053520 71.4286 µM -1.24067146206684 0.101837280669158 no 3057 0.107363570396916 4354 4647384
SGTC_2135 5326629 150.42 µM -1.24122441079841 0.101737973430502 no 3058 0.107261429738154 4268 5020077
SGTC_1552 6-methylflavone 10.6 µM -1.24316904543122 0.101389285306586 no 3059 0.106902773424758 4273 689013
SGTC_2870 9038528 12.99 µM -1.24399667634956 0.10124114903395 no 3060 0.106750393086532 4355 6463316
SGTC_2916 7875993 68.79 µM -1.24831022300661 0.100471627041062 no 3061 0.105958735925708 4164 1299250
SGTC_1096 rimcazole 32.2 µM -1.24844675608447 0.100447339876773 no 3062 0.105933747719683 4245 18528119 A dopamine reuptake inhibitor.
SGTC_2847 9005661 71.43 µM -1.2494043659011 0.100277115992012 no 3063 0.105758606194012 4362 2991449
SGTC_518 1021-0119 62.6 µM -1.25271361230401 0.0996904883497013 no 3064 0.10515497512575 4294 1097762
SGTC_1697 st025554 27.742 µM -1.25307627399232 0.0996263523494822 no 3065 0.105088974843917 4336 1269519
SGTC_1521 st012942 49.4 µM -1.25343883429417 0.0995622644224979 no 3066 0.105023022987225 4278 24207259
SGTC_1759 st043059 70 µM -1.25559515343501 0.0991817253021261 no 3067 0.104631394724846 4338 669426
SGTC_1772 st048439 82.2 µM -1.25729719083489 0.0988821080618743 no 3068 0.104323020417756 4381 2927068 YDL195W SEC31
SGTC_2187 6125751 200 µM -1.25898448157006 0.0985857409304207 no 3069 0.104017968568308 4347 874498
SGTC_2756 carbadox 75.1 µM -1.26290711497056 0.0978992572370937 no 3070 0.103311281333072 4273 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2191 5911152 200 µM -1.26707898183441 0.0971730077223571 no 3071 0.102563525050392 4355 2875902
SGTC_410 α-linolenic acid 100 µM -1.26802499166046 0.0970088751710586 no 3072 0.10239451293082 4370 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_490 phenamil 164 µM -1.26839978935987 0.096943904146811 no 3073 0.102327608409453 4325 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2287 7945887 168.79 µM -1.26850676530009 0.0969253657739173 no 3074 0.102308518143672 4353 1245853
SGTC_212 3807-4682 38.772 µM -1.26977696810794 0.096705445136515 no 3075 0.102082043536989 4407 3125501 YBL034C STU1
SGTC_835 0312-0010 67.2 µM -1.26999550618673 0.0966676448255196 no 3076 0.102043115442499 4353 1626196
SGTC_2140 5586273 200 µM -1.27011731956062 0.096646579600226 no 3077 0.102021421567284 4308 854421
SGTC_2895 9054447 58.44 µM -1.27185594302732 0.096346286309037 no 3078 0.101712153941822 4405 2697450
SGTC_1612 st002233 45.4 µM -1.27311848871474 0.0961286508517622 no 3079 0.101487999564445 4354 1035021
SGTC_1007 4101-0031 70 µM -1.27465808498864 0.0958637472561058 no 3080 0.101215144338713 4335 1146276
SGTC_2813 7971799 71.43 µM -1.27732814191539 0.0954056098307097 no 3081 0.100743211109217 4358 2234054
SGTC_2908 7930301 100 µM -1.27828461261122 0.0952418880424189 no 3082 0.100574545675001 4309 2223178
SGTC_1004 4084-0029 199 µM -1.27866948792311 0.0951760662525565 no 3083 0.100506734357671 4360 716894 YLR208W SEC13
SGTC_1636 st007707 68.9 µM -1.2824722168356 0.094527519275938 no 3084 0.0998385225362581 4360 403051
SGTC_1687 st020778 55.3625 µM -1.28426062301927 0.0942236394619667 no 3085 0.0995253898648238 4366 4259299
SGTC_1313 1220-0047 237 µM -1.28583329223474 0.0939570128978245 no 3086 0.0992506242885379 4341 3528706
SGTC_1158 4092-0494 91.8 µM -1.28587724979558 0.0939495684455409 no 3087 0.0992429523124564 4430 1148199
SGTC_126 0417-1624 672.48 µM -1.28784113653408 0.0936174175349398 no 3088 0.0989006346651955 4409 41912 YDL195W SEC31
SGTC_271 rotenone 740 µM -1.29179542694503 0.0929512630468232 no 3089 0.0982139997392993 4392 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_876 0720-0963 56.8 µM -1.30287870650978 0.0911028171962844 no 3090 0.0963080873131942 4395 765861
SGTC_3232 9132874 49.47 µM -1.30662677751469 0.0904839312363084 no 3091 0.0956697488769984 4332 3784940
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -1.3110800106989 0.0897526721877539 no 3092 0.0949153666876653 4338 6857784
SGTC_1634 st006576 41 µM -1.31226914019777 0.0895581521561292 no 3093 0.0947146703077862 4356 3915356
SGTC_1365 1672-3266 55.4 µM -1.31622712093152 0.0889129566096642 no 3094 0.0940489117189352 4397 6415873
SGTC_315 k915-0449 187 µM -1.31637985354073 0.088888128994516 no 3095 0.0940232904513284 4407 20970215 YNL149C PGA2
SGTC_2687 chenodiol 100 µM -1.31966814384148 0.0883548484939043 no 3096 0.0934729202134022 4428 5702181 A cholesterol synthesis inhibitor.
SGTC_1701 st028638 40.4 µM -1.31998697380337 0.0883032691120349 no 3097 0.0934196835668982 4389 3490878
SGTC_3091 9116372 49.47 µM -1.32334392554701 0.0877615526024938 no 3098 0.0928605151786257 4438 17169793
SGTC_1454 4239-0054 42.6 µM -1.32341390054424 0.0877502870642553 no 3099 0.0928488858110186 4454 1340767
SGTC_328 k915-0120 63.5 µM -1.32476773668804 0.0875325401766034 no 3100 0.0926240993912076 4394 6624543
SGTC_768 0384-0033 77.3 µM -1.3282944464647 0.0869672085579743 no 3101 0.0920404268358466 4337 3965305 YMR134W ERG29
SGTC_2726 cimetidine 79.27 µM -1.32850025327473 0.0869343021472101 no 3102 0.0920064499786572 4367 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_3214 9129694 49.47 µM -1.32996771556239 0.0866999394503193 no 3103 0.0917644542935287 4413 17158655
SGTC_1453 4237-0541 195 µM -1.33018339966995 0.0866655332176771 no 3104 0.0917289261255502 4384 739892
SGTC_2190 6049624 200 µM -1.33098128043339 0.0865383428528542 no 3105 0.0915975852597954 4283 2265554
SGTC_3337 9144342 33.5465 µM -1.33179867525318 0.0864081865036571 no 3106 0.0914631767039753 4392 17682949
SGTC_3197 9113331 49.47 µM -1.34334583330832 0.0845851058584132 no 3107 0.0895800087626025 4391 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.34455144117498 0.0843964389222531 no 3108 0.0893850668328177 4377 16623 A steroid.
SGTC_2035 5154463 94.595 µM -1.3456471155847 0.0842252496394731 no 3109 0.089208174576674 4410 2769623
SGTC_397 arbidol 50 µM -1.34640582486651 0.0841068609402057 no 3110 0.0890858367201396 4432 131410 A RNA synthesis inhibitor.
SGTC_1345 1488-0192 31.4 µM -1.34659273015662 0.0840777154993591 no 3111 0.089055718408878 4449 658348
SGTC_415 dibenzyl ketone 100 µM -1.35298438993833 0.0830855770401364 no 3112 0.0880303086793048 4393 7593
SGTC_903 1134-0042 114 µM -1.35358887475241 0.0829922041892895 no 3113 0.0879337891201742 4403 701009
SGTC_2189 6047310 154.431 µM -1.35643243203814 0.082554027614515 no 3114 0.0874808100481428 4387 711535
SGTC_2415 st077333 57.7 µM -1.35754902441799 0.0823824438334547 no 3115 0.0873034137148183 4429 2766255
SGTC_3245 9134821 49.47 µM -1.35954662443269 0.0820761480895521 no 3116 0.0869867193189168 4417 17014901
SGTC_740 k014-0057 261 µM -1.36512864553054 0.081224795125632 no 3117 0.0861063100691253 4402 4012779
SGTC_2311 7694451 200 µM -1.36933527972046 0.0805876271503056 no 3118 0.0854472474080671 4410 2163142
SGTC_3016 9080866 49.47 µM -1.37260981872339 0.0800942600083536 no 3119 0.0849368389159247 4371 17066299
SGTC_1013 4112-3890 241 µM -1.37422040369024 0.0798524362473329 no 3120 0.0846866341230119 4379 705171
SGTC_187 1488-2104 32.728 µM -1.37945204304114 0.0790707332401395 no 3121 0.0838777113484446 4424 2852859
SGTC_1852 st056254 31.4 µM -1.3802700608779 0.0789490320639904 no 3122 0.0837517547523275 4381 442583
SGTC_2626 ethyl orsellinate 100 µM -1.38576682186105 0.078134924928575 no 3123 0.0829090582292186 4360 75653 A natural product.
SGTC_1081 sertraline 6 µM -1.39163932872419 0.077272220052116 no 3124 0.0820158215620971 4413 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2369 9071472 200 µM -1.39279791563089 0.0771028749151569 no 3125 0.0818404544551073 4450 17296037
SGTC_651 3253-0966 34.4 µM -1.39955131386441 0.0761213712701136 no 3126 0.0808238609739967 4445 781462
SGTC_2970 9090938 41.86 µM -1.40080223855517 0.07594061701838 no 3127 0.080636609529522 4479 17217104
SGTC_2267 7931562 200 µM -1.40080877248533 0.0759396737470335 no 3128 0.0806356323236598 4385 934880
SGTC_157 1348-1695 65.819 µM -1.40361295051983 0.0755356713381126 no 3129 0.0802170682955611 4355 5380510
SGTC_3186 9110464 49.47 µM -1.40879880627129 0.0747928546905704 no 3130 0.0794473341216661 4428 17018021
SGTC_1791 st048313 56.1 µM -1.41027292279184 0.0745827244063175 no 3131 0.0792295552931609 4462 1204976
SGTC_2407 paclitaxel 400 µM -1.41110141762994 0.0744648232464175 no 3132 0.0791073560375154 4474 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2014 4013930 200 µM -1.41652315317605 0.0736967782262962 no 3133 0.0783111950940728 4420 64556
SGTC_1994 st072947 40.9 µM -1.41861587328183 0.0734019478918449 no 3134 0.078005517793145 4488 5286565 YDL195W SEC31
SGTC_91 0417-1751 58.384 µM -1.41963846850294 0.0732582093108029 no 3135 0.0778564800539964 4551 6795624
SGTC_2923 7992654 58.14 µM -1.42185327609378 0.0729476287062943 no 3136 0.0775344248182516 4436 2985126
SGTC_291 SEC14.278 35.5 µM -1.42258327796072 0.0728454823060892 no 3137 0.0774284971837757 4463 1068044
SGTC_184 1494-0393 24.714 µM -1.42395367076932 0.0726540241991856 no 3138 0.0772299418796904 4434 3090647
SGTC_1727 st034309 9.9045 µM -1.4310723727772 0.0716656625766284 no 3139 0.0762047371274159 4474 870305
SGTC_2855 9016525 58.44 µM -1.4314362768872 0.0716154165701174 no 3140 0.0761526088580259 4400 43811474
SGTC_336 4111-0029 111 µM -1.43161218743839 0.0715911374391937 no 3141 0.076127419885804 4462 3131175
SGTC_1891 st059073 26.2 µM -1.4327176389885 0.0714387078082108 no 3142 0.0759692732742336 4525 688754
SGTC_2725 haloperidol 53.21 µM -1.43339023021633 0.0713460868137675 no 3143 0.0758731744141668 4420 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.43684387029396 0.0708719451482335 no 3144 0.075381180883092 4456 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2399 5884133 200 µM -1.43716280393029 0.0708282819240615 no 3145 0.0753358696387823 4412 722445
SGTC_858 0438-0351 2.77 µM -1.43824683064135 0.0706800290489253 no 3146 0.0751820159972109 4438 2799119
SGTC_2112 5488546 200 µM -1.44523563581393 0.0697299495836183 no 3147 0.074195854967973 4422 600757
SGTC_3195 9113082 49.47 µM -1.45408639049126 0.0685408958094778 no 3148 0.0729611781311501 4459 17018038
SGTC_234 nsc-17383 10.7 µM -1.45948220884012 0.0678237065319537 no 3149 0.0722162169337269 4475 408974
SGTC_1815 st051655 58.2 µM -1.46182003165493 0.0675147784820416 no 3150 0.0718952666500564 4412 5984156
SGTC_667 1498-1044 59 µM -1.46264226632994 0.0674063843784282 no 3151 0.0717826457423911 4469 6739982
SGTC_323 4013-0906 34.3 µM -1.47041694940142 0.0663880965947464 no 3152 0.0707244318134388 4493 2910086
SGTC_2758 dehydroepiandrosterone 69.35 µM -1.47083851042149 0.0663332250164318 no 3153 0.0706673975014621 4464 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1105 epirubicin 18.1 µM -1.47112002688936 0.0662966015960582 no 3154 0.0706293299438741 4514 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_411 enrofloxacin 100 µM -1.47898801493087 0.0652793504756127 no 3155 0.0695717590192251 4517 71188 A bacterial gyrase inhibitor.
SGTC_1334 1486-0610 236 µM -1.47909171124696 0.0652660249020157 no 3156 0.0695579026001151 4539 3742339
SGTC_780 0109-0199 192 µM -1.48611308598595 0.0643686375697313 no 3157 0.0686246057651755 4518 610414
SGTC_673 1082-0474 110 µM -1.48892538035369 0.0640119048709033 no 3158 0.0682535096639359 4472 3098046
SGTC_3006 9075424 71.4286 µM -1.49053068546069 0.0638089660957338 no 3159 0.0680423771621318 4448 7465181
SGTC_565 1418-0001 44.5 µM -1.49128490363153 0.0637137926242588 no 3160 0.0679433553503134 4525 2862145
SGTC_1656 st012921 11 µM -1.49558647641466 0.0631730942420917 no 3161 0.0673807247229305 4402 6732821
SGTC_2077 5212015 200 µM -1.49800793019628 0.0628702984097287 no 3162 0.0670655950510403 4403 780900
SGTC_1597 7-benzyloxygramine 47.5 µM -1.5017163655456 0.0624087626909692 no 3163 0.0665851877540758 4393 260807
SGTC_2877 9040724 71.43 µM -1.51004208922486 0.0613822056434721 no 3164 0.0655163423920599 4468 6463895
SGTC_1849 st056239 19.2 µM -1.52132946799269 0.0600115994237275 no 3165 0.0640885894458916 4496 5393181
SGTC_3131 9127911 49.47 µM -1.52377210818763 0.0597181723464253 no 3166 0.0637828246627742 4501 45595681
SGTC_1269 0831-0796 3.05 µM -1.52593592081675 0.0594591800217761 no 3167 0.0635129118764158 4536 927758
SGTC_1773 st048542 73.5835 µM -1.52817704529168 0.0591918631010251 no 3168 0.0632342932236341 4495 3237138
SGTC_618 k072-0232 33.2 µM -1.53063720054567 0.0588995067766334 no 3169 0.0629295411816127 4537 5872756 YGL099W LSG1
SGTC_2788 5282734 71.43 µM -1.53842225967383 0.0579818185305673 no 3170 0.0619727015330163 4532 743706
SGTC_1527 coumarin 137 µM -1.53874555773346 0.0579439531717717 no 3171 0.0619332127785767 4548 323 A hepatotoxic, DNA x-linker.
SGTC_65 0798-0905 34.986 µM -1.53903861403081 0.0579096465893853 no 3172 0.0618974348287371 4512 3602145
SGTC_2103 5378138 10 µM -1.54161594471327 0.0576086190891366 no 3173 0.0615834742897366 4587 244142
SGTC_478 N-arachidonylglycine 10 µM -1.54339614084287 0.0574014150139159 no 3174 0.0613673447334904 4555 5283389
SGTC_659 k018-0002 107 µM -1.54459060726623 0.0572627153507927 no 3175 0.0612226597810923 4490 6797879 YHR007C ERG11
SGTC_185 k048-0037 25.491 µM -1.54644586263414 0.0570478089754544 no 3176 0.0609984625884552 4570 6827589
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -1.55149710288763 0.0564659078756153 no 3177 0.0603913005445434 4503 5379071
SGTC_1215 3852-0577 11.2 µM -1.55494397656278 0.0560715215220199 no 3178 0.0599797062831777 4548 2884876
SGTC_2373 9071805 200 µM -1.57046481026808 0.05432249915925 no 3179 0.0581535074584117 4538 10149009
SGTC_1499 4480-0877 67.3 µM -1.57067701276842 0.0542988889224714 no 3180 0.0581288456461599 4523 2861909
SGTC_2365 9042475 200 µM -1.57206360617683 0.0541448124991414 no 3181 0.0579679003563376 4564 6464479
SGTC_2907 7721985 69.9 µM -1.57301708117611 0.0540390645326774 no 3182 0.0578574315526988 4528 3267881
SGTC_88 0180-0332 8.668 µM -1.57629569732922 0.0536766870204975 no 3183 0.0574788363887549 4606 3101745
SGTC_3015 9080845 49.47 µM -1.57666229889535 0.0536362873627055 no 3184 0.0574366248308818 4573 5296973
SGTC_2998 9066762 71.4286 µM -1.57965375183393 0.053307527412823 no 3185 0.05709309116094 4544 4945196
SGTC_432 NS 1619 61.3 µM -1.58590358661311 0.0526258272541768 no 3186 0.0563805910515419 4510 4552 A K+/calcium channel activator.
SGTC_2457 5731572 11.68 µM -1.58890078301965 0.052301371941015 no 3187 0.0560413971967308 4586 2865357
SGTC_2437 5741531 144.16 µM -1.60071668995603 0.0510377131847755 no 3188 0.0547198414199119 4555 2262990
SGTC_1613 st002381 52.1 µM -1.60735812805328 0.05033818076102 no 3189 0.0539879148805856 4557 551167
SGTC_214 4373-3496 70 µM -1.61076451555096 0.0499823673730576 no 3190 0.0536155289775564 4609 3779166
SGTC_908 3448-7491 47.7 µM -1.61162483795132 0.0498928205795364 no 3191 0.0535218012020058 4557 1203031
SGTC_2808 7946468 45.46 µM -1.61380388760853 0.049666586268348 no 3192 0.0532849855262219 4527 2970879
SGTC_2322 7413319 38.22 µM -1.62342115653939 0.0486778595248101 no 3193 0.0522497025557899 4494 1840400
SGTC_2740 felodipine 17.08 µM -1.62369209830942 0.0486502342473283 no 3194 0.0522207691355232 4617 3333 L-type calcium channel blocker
SGTC_1913 st060213 96.1 µM -1.62408015834117 0.0486106894000388 no 3195 0.0521793510163255 4533 688959
SGTC_3101 9120531 49.47 µM -1.62493392011149 0.0485237781713336 no 3196 0.0520883198300872 4529 24824904
SGTC_1622 st003707 19.4 µM -1.62860422573037 0.0481515627525764 no 3197 0.0516984145667573 4566 10140899
SGTC_619 1652-1634 108 µM -1.6325955233762 0.0477493913970324 no 3198 0.0512770466877578 4549 5400454
SGTC_1944 st076371 56.9 µM -1.63660253830379 0.0473483464854221 no 3199 0.0508567724582922 4513 24208455
SGTC_2285 7945142 200 µM -1.63964173903512 0.0470459696319242 no 3200 0.0505398396194439 4568 2970608
SGTC_1190 1486-1332 13 µM -1.64128636041851 0.046882989353034 no 3201 0.0503689930356865 4553 4150046
SGTC_456 gingerol 170 µM -1.6427834341162 0.0467350249142883 no 3202 0.0502138744432685 4571 442793 A herb.
SGTC_1266 0828-0227 32.9 µM -1.64322666580744 0.0466912897186402 no 3203 0.0501680223284671 4542 3913820
SGTC_1292 0kpi-0043 232 µM -1.64898157854084 0.0461264086203723 no 3204 0.0495757043639294 4578 3333905
SGTC_1850 st056238 17 µM -1.65876236078656 0.045178966283435 no 3205 0.0485818438372167 4573 5393177
SGTC_2481 5478948 45.16 µM -1.66580738111487 0.0445062813291219 no 3206 0.0478758927688634 4561 77792
SGTC_2050 5263056 171 µM -1.66795629044955 0.0443027090605167 no 3207 0.0476622019950227 4549 763468 YGL055W OLE1
SGTC_503 tyrphostin 8 294 µM -1.68156263382565 0.0430311011175366 no 3208 0.0463268407251046 4588 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2757 clomiphene 4.22 µM -1.69808698674107 0.041526611913894 no 3209 0.0447456726542302 4582 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2352 9027995 87.8 µM -1.7111710222083 0.040365829113379 no 3210 0.0435247731820729 4558 2997347
SGTC_502 l-744,832 89.3 µM -1.71859084634955 0.0397193570965278 no 3211 0.0428444498015674 4607 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2560 caryophyllene 100 µM -1.71974628913029 0.0396194477515548 no 3212 0.0427392848375821 4626 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1690 st023502 41.2 µM -1.72811048835262 0.0389022883114482 no 3213 0.0419842087295883 4604 24207482
SGTC_2854 9024559 71.43 µM -1.72819015510505 0.0388955087282082 no 3214 0.0419770690918375 4584 3163529
SGTC_2400 5203494 178.7 µM -1.74329402925945 0.0376274587829166 no 3215 0.0406411338919615 4512 6777674
SGTC_589 1227-0070 34.1 µM -1.74942267578244 0.0371226463110646 no 3216 0.0401089920170557 4650 2841384
SGTC_3017 9080681 49.47 µM -1.75152249988397 0.0369509635239009 no 3217 0.0399279745436665 4629 16451914
SGTC_727 3032-0951 202 µM -1.75451606180316 0.0367073310699015 no 3218 0.0396710600869975 4631 3652836
SGTC_2787 5284540 71.43 µM -1.75998432284462 0.0362656866645692 no 3219 0.039205232358007 4606 736958
SGTC_2222 6885208 172.143 µM -1.76854595140046 0.0355829511254794 no 3220 0.0384848386457948 4651 609514
SGTC_99 0109-0120 622.8 µM -1.77529836058669 0.0350519522483854 no 3221 0.0379243179839904 4623 759414
SGTC_705 1124-0212 310 µM -1.77604182888527 0.0349938865522633 no 3222 0.0378630115068331 4599 9554485
SGTC_1604 st002052 72.4 µM -1.77977071583172 0.0347038461349866 no 3223 0.0375567459910242 4644 6254834 YHR062C RPP1
SGTC_504 lovastatin 124 µM -1.78301936816389 0.0344527712100435 no 3224 0.0372915752837503 4610 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_281 1672-3440 14.9 µM -1.78692005116904 0.0341532773756646 no 3225 0.0369752056152687 4656 6833000
SGTC_920 mycophenolic acid 780.421 nM -1.80032205594389 0.03314054259753 no 3226 0.0359049001140308 4603 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_22 0964-0034 14.468 µM -1.80053372668775 0.0331247481496998 no 3227 0.0358882015430218 4634 138402
SGTC_3208 9114115 49.47 µM -1.80711743516495 0.0326365728999718 no 3228 0.0353719853595553 4570 650895
SGTC_245 methotrexate 289.6 µM -1.8083619503286 0.0325449634433795 no 3229 0.0352750929172519 4585 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2551 apiole 73.87 µM -1.81530645435581 0.0320376607526211 no 3230 0.0347384138350104 4582 10659 A possible DNA adduct former.
SGTC_832 4083-0019 164 µM -1.82118986350038 0.0316129975799655 no 3231 0.0342890003938846 4666 1990758
SGTC_2379 9035213 200 µM -1.82496444143174 0.0313430070012457 no 3232 0.0340031977422367 4634 646551
SGTC_115 0527-0192 112.043 µM -1.82519003300157 0.0313269313032243 no 3233 0.0339861786776498 4593 4233931
SGTC_1500 4488-1866 171 µM -1.83058784590143 0.0309443109731458 no 3234 0.0335810420131084 4666 2900003
SGTC_2941 9056145 11.23 µM -1.83179519716603 0.0308592600918748 no 3235 0.0334909695387355 4593 2119517
SGTC_1291 0993-0025 5.79 µM -1.83271451413286 0.0307946293918371 no 3236 0.0334225188517007 4625 4353356
SGTC_3120 9124077 49.47 µM -1.8398988040324 0.0302934027790186 no 3237 0.0328915478242146 4718 18774327 YGL155W CDC43
SGTC_64 000l-0018 272.079 µM -1.83991475335917 0.0302922976087129 no 3238 0.0328903768341396 4555 6811119
SGTC_564 3555-0129 330 µM -1.84446797961295 0.0299781563053218 no 3239 0.0325574840906169 4594 563260
SGTC_2366 9070441 60.58 µM -1.84447116788253 0.0299779372868122 no 3240 0.0325572519690895 4607 6837235
SGTC_50 0929-0078 56.389 µM -1.84643798783897 0.029843079064307 no 3241 0.0324143178473155 4507 1377751
SGTC_700 3453-2283 142 µM -1.85355681188122 0.0293591657816807 no 3242 0.0319012955953171 4678 565664
SGTC_274 sirtinol 40.1 µM -1.85501854607839 0.02926061273967 no 3243 0.0317967891129428 4675 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_186 3455-3465 67.277 µM -1.85739449822096 0.0291010076659466 no 3244 0.0316275243296555 4678 755278
SGTC_590 k048-0076 22.4 µM -1.85779308228358 0.0290743036785229 no 3245 0.0315992019423771 4662 6832814
SGTC_2513 baicalein 25.65 µM -1.87517372141167 0.0279295007803759 no 3246 0.0303844140623355 4621 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1932 st074806 40.9 µM -1.87617455881491 0.0278647387579833 no 3247 0.0303156571576192 4655 17251235
SGTC_3113 9123498 49.47 µM -1.88318347113986 0.0274147043629525 no 3248 0.0298377541209708 4717 8897275
SGTC_458 nppb 133 µM -1.88341307453497 0.0274000649183195 no 3249 0.0298222049281049 4669 4549 A chloride channel blocker.
SGTC_2882 9058044 58.44 µM -1.88637897197937 0.0272115454644247 no 3250 0.0296219520740617 4665 18076804
SGTC_986 1493-0483 84 µM -1.88834547795217 0.0270871472425331 no 3251 0.0294897928518355 4630 40079
SGTC_1937 st074714 47.2 µM -1.88917546331653 0.0270347862114775 no 3252 0.0294341606863392 4602 17250970
SGTC_78 0336-0123 156.75 µM -1.88995123698534 0.026985921620846 no 3253 0.0293822410266486 4545 6765896
SGTC_3097 9117246 49.47 µM -1.89185543277775 0.0268662922240978 no 3254 0.0292551225946694 4664 16423892
SGTC_3168 9103419 49.47 µM -1.89966923936321 0.0263800233170618 no 3255 0.0287382697653264 4704 16649256
SGTC_263 alizarin 107.927 µM -1.90072253317367 0.0263150408514399 no 3256 0.0286691827446045 4676 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_554 4483-2211 187 µM -1.91676087253743 0.0253419820009198 no 3257 0.027634158947667 4686 747107
SGTC_2321 7390090 138.78 µM -1.92051048928594 0.0251188894676456 no 3258 0.0273967247523396 4657 649046
SGTC_223 busulfan 5 mM -1.931252835515 0.0244888428103198 no 3259 0.0267258964608399 4671 2478 A DNA alkylator.
SGTC_732 3970-1727 52.7 µM -1.93947002924941 0.024015899619629 no 3260 0.02622206526186 4701 1275699
SGTC_2007 4011539 71.82 µM -1.94281051362736 0.0238258432589152 no 3261 0.0260195285676946 4649 45595301
SGTC_2516 gossypol 71.55 µM -1.94450305618885 0.0237300299123483 no 3262 0.0259174086178548 4674 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1204 4049-0315 18.3 µM -1.94518336775083 0.023691609457242 no 3263 0.0258764564464972 4648 588402
SGTC_1739 st037196 92.5 µM -1.94732040527241 0.0235712607762089 no 3264 0.0257481669235568 4675 612214
SGTC_374 0880-0231 82.3 µM -1.95317198950622 0.0232443539162301 no 3265 0.025399609474224 4549 6833587
SGTC_728 3030-5151 22.5 µM -1.95552137059994 0.023114180476141 no 3266 0.0252607817388921 4712 3125388
SGTC_3055 9094636 49.47 µM -1.95867447900952 0.0229404396852403 no 3267 0.0250754605385719 4665 25236176
SGTC_2057 5236571 38.335 µM -1.96278949416372 0.0227153522818919 no 3268 0.0248353195248696 4621 54684039 YBR257W POP4
SGTC_1802 st050112 57.9 µM -1.97421251763838 0.0221002579997188 no 3269 0.0241787916232997 4690 4662563
SGTC_2721 ifenprodil 61.44 µM -1.97563285466224 0.0220247691377967 no 3270 0.0240981873742682 4651 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2361 9034121 116 µM -1.98771050134381 0.0213916117033645 no 3271 0.0234218584186575 4690 6496917
SGTC_132 0417-1715 25.805 µM -1.99192043605644 0.0211745583617481 no 3272 0.0231898941671749 4660 6769098
SGTC_2218 6965428 192.983 µM -2.00159771140008 0.0206826773287047 no 3273 0.0226640076771623 4620 675684
SGTC_1763 st044482 94.5 µM -2.00243496005271 0.0206405798342992 no 3274 0.0226189858260233 4673 88505
SGTC_1489 4065-0444 182 µM -2.00361220589926 0.0205815098088832 no 3275 0.0225558086646747 4692 2877968
SGTC_138 0850-0259 40.9225 µM -2.0129404205294 0.0201184967507626 no 3276 0.0220604487957316 4625 6813004
SGTC_1911 st060208 74.3 µM -2.013801429374 0.0200762087623454 no 3277 0.0220151928030087 4689 688783
SGTC_751 0833-0568 350 µM -2.01464405694639 0.0200348965793271 no 3278 0.0219709788685034 4695 6954252
SGTC_487 nimodipine 119 µM -2.01562701994432 0.0199867952063967 no 3279 0.0219194960851315 4711 4497 L-type voltage-gated calcium channels inhibitor
SGTC_929 2805-0021 398 µM -2.01825205467682 0.0198588188653106 no 3280 0.0217825086502446 4692 3098024
SGTC_1821 st053465 65.6 µM -2.01926364554214 0.0198096875033337 no 3281 0.0217299121567429 4708 675086
SGTC_2055 5235184 200 µM -2.04168358792114 0.0187469785691286 no 3282 0.0205914638946062 4671 2836034
SGTC_2800 7887935 81.82 µM -2.04659555100297 0.0185207437513362 no 3283 0.0203489060233335 4671 2961002
SGTC_2417 cerulenin 830 nM -2.05131703583227 0.0183054773783873 no 3284 0.0201180412590974 4684 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1187 1391-0724 117 µM -2.05906736904854 0.0179567387499497 no 3285 0.019743892616721 4728 6997986
SGTC_1343 1487-0095 224 µM -2.06852002835992 0.0175390843879442 no 3286 0.0192955746288069 4686 4560101 YGL055W OLE1
SGTC_856 0433-0016 11.3 µM -2.07206069682754 0.0173847932956109 no 3287 0.0191298905373833 4712 3911780
SGTC_2760 etidronate 98.04 µM -2.07683460532422 0.0171785976885939 no 3288 0.0189084135444352 4667 3305 A chelator and antioxidant.
SGTC_1981 st071826 47 µM -2.08627192009222 0.0167771228562964 no 3289 0.0184769993622547 4726 11838600
SGTC_110 0850-0284 111.64 µM -2.09205654959643 0.0165350266777601 no 3290 0.018216728686219 4689 3906265
SGTC_3309 9129340 25.759 µM -2.10936561081184 0.0158283966659244 no 3291 0.0174565177340078 4689 17158987
SGTC_546 peri-Naphthalide 147 µM -2.11221080287217 0.0157147577003687 no 3292 0.0173341861747218 4688 223824 A penicillin ester.
SGTC_607 4491-0986 66.8 µM -2.11869531061483 0.0154583744563606 no 3293 0.0170581124566542 4700 698981 YDR232W HEM1
SGTC_933 2914-0560 114 µM -2.12308493162911 0.0152868637035716 no 3294 0.0168733677338496 4709 463887
SGTC_2371 9071574 200 µM -2.12912499320884 0.0150535403827986 no 3295 0.016621960228834 4726 45596039
SGTC_1977 st070720 65.3 µM -2.13174047113205 0.0149534598174019 no 3296 0.0165140938978697 4706 682188
SGTC_807 1315-0151 48 µM -2.14903288581979 0.01430605482713 no 3297 0.0158158965846524 4704 4011080
SGTC_2084 5306078 60.6385 µM -2.15024688437126 0.0142615252366586 no 3298 0.0157678456950287 4683 679340
SGTC_2094 5332512 191.667 µM -2.16184555394502 0.0138420702494684 no 3299 0.0153150414295775 4728 755774
SGTC_2276 7947513 42.08 µM -2.16260875117799 0.0138148469117545 no 3300 0.0152856423043152 4646 2105100
SGTC_2658 polymyxin b sulfate 77.05 µM -2.16332995944534 0.0137891637737334 no 3301 0.0152579051927252 4743 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_475 α-linolenic acid 10 µM -2.17382264320894 0.0134201386430995 no 3302 0.0148592286677077 4715 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2944 9067346 25.62 µM -2.19408717466071 0.0127315268212747 no 3303 0.0141145715552462 4644 6473075
SGTC_2659 sanguinarine 24.21 µM -2.19625950346912 0.0126595555040591 no 3304 0.0140366872641291 4707 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_116 0155-0182 31.788 µM -2.22809172013757 0.0116446214257487 no 3305 0.0129371996592718 4623 771486
SGTC_501 nsc-95397 161 µM -2.25076828074041 0.010965398387865 no 3306 0.0122001087583984 4724 262093
SGTC_1382 3002-2117 298 µM -2.25291493304187 0.0109029232379354 no 3307 0.0121322565607419 4750 1497314
SGTC_56 0957-0365 83.25 µM -2.28763004615088 0.00993476485827102 no 3308 0.0110795373087636 4690 6752360
SGTC_1205 4161-2785 76 µM -2.28792617262112 0.00992684003743476 no 3309 0.0110709104213392 4719 3498106
SGTC_3336 9143619 71.43 µM -2.29214994690696 0.00981440437740977 no 3310 0.0109484960407067 4720 45595730
SGTC_3157 9099274 49.47 µM -2.29638319507618 0.00970283415294837 no 3311 0.010826990487508 4740 17217662
SGTC_1874 staurosporine 7.6 µM -2.30997849836158 0.00935198076401329 no 3312 0.0104446722757804 4740 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_152 4469-0003 551.229 µM -2.31040188855663 0.00934123489635369 no 3313 0.010432957319559 4725 697280
SGTC_114 0364-0001 490.298 µM -2.32000589866782 0.0091003648652805 no 3314 0.010170279122057 4729 4003655
SGTC_306 1672-3436 11.6 µM -2.32634690652917 0.0089443280932284 no 3315 0.0100000257862878 4754 6797378
SGTC_828 2074-0507 139 µM -2.33483128811793 0.00873921707944263 no 3316 0.00977611800404471 4756 X828
SGTC_2648 atorvastatin 78.68 µM -2.33632073296692 0.00870363825532977 no 3317 0.00973726587126851 4751 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_1844 rapamycin 4 nM -2.36963198882502 0.00794043546191871 no 3318 0.00890289921200252 4602 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2679 rapamycin 1 nM -2.37088370424159 0.0079129416963438 no 3319 0.00887280686576725 4617 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_918 glabranin 770.725 nM -2.38890763627109 0.00752623065152305 no 3320 0.00844927506338887 4735 124049 Also referred to as licorice root.
SGTC_101 0490-5701 117.494 µM -2.39598059554352 0.00737908596560128 no 3321 0.00828798391156643 4685 4661669
SGTC_95 0471-0001 561.058 µM -2.41681571367823 0.00696026687731039 no 3322 0.00782847088493668 4743 4015405
SGTC_2376 9072922 81.32 µM -2.4400162257093 0.00651872041355603 no 3323 0.0073433011198869 4745 17087968
SGTC_2982 9019404 25.97 µM -2.44073912178405 0.00650536970036493 no 3324 0.00732861936660301 4724 22333232
SGTC_2347 9049783 174.81 µM -2.49557094924832 0.00556060480928823 no 3325 0.00628773019775268 4744 6467988 YPL169C MEX67
SGTC_1490 4089-0339 670 nM -2.52489375128205 0.00510714410575611 no 3326 0.00578666367760726 4778 742542
SGTC_1916 st067606 49.2 µM -2.52553001606325 0.00509768060012868 no 3327 0.00577619561643791 4690 19590279
SGTC_1606 st000094 49.2 µM -2.53673887037118 0.00493350605300997 no 3328 0.00559451899649089 4760 1242210
SGTC_2673 kobusone 100 µM -2.54539534764094 0.00480995728663156 no 3329 0.00545770386412655 4795 6710676 An epoxy ketone and protein crosslinker.
SGTC_1239 0337-0584 35.4 µM -2.54746279101734 0.00478086107940141 no 3330 0.00542547121199783 4760 914301 YML130C ERO1
SGTC_551 k048-0028 34.9 µM -2.60726093350045 0.00400441190295593 no 3331 0.0045634889538728 4739 6836383
SGTC_3216 9129716 49.47 µM -2.61874389871603 0.00386894478965122 no 3332 0.00441270883607111 4712 8056934
SGTC_1188 1403-0014 4.57 µM -2.69504492855203 0.00306842744779358 no 3333 0.00351895702601172 4783 9614867
SGTC_288 1315-0019 35.1 µM -2.7000269136433 0.00302175857088859 no 3334 0.00346669334790831 4779 6811474
SGTC_103 0844-0104 51.839 µM -2.71811473582316 0.00285764762356887 no 3335 0.0032827533337185 4640 5375804
SGTC_655 k060-0012 42 µM -2.72055087728684 0.00283616982585797 no 3336 0.00325866209366964 4780 5994525
SGTC_1562 morin hydrate 59.1 µM -2.73608221682662 0.00270263035710259 no 3337 0.00310877447455749 4772 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1942 st076330 65.2 µM -2.78684747003665 0.00230481744872139 no 3338 0.00266117621064168 4769 24208414
SGTC_1229 0139-0193 12.2 µM -2.79318791753772 0.0022590496360544 no 3339 0.00260956813868511 4797 3090752
SGTC_825 1988-2224 89.6 µM -2.79524043744782 0.00224441112077637 no 3340 0.00259305642963524 4777 1180859
SGTC_3123 9126162 49.47 µM -2.80841289024001 0.00215249350902901 no 3341 0.00248931747601395 4777 25239884
SGTC_2380 9035439 200 µM -2.81695506194878 0.00209472466097491 no 3342 0.00242406542640336 4782 6462575
SGTC_206 4546-0025 72.014 µM -2.86100838460941 0.00181853005447095 no 3343 0.0021114794172283 4786 6620745 YIL048W NEO1
SGTC_2783 7738165 71.43 µM -2.95089008553839 0.00135506574703368 no 3344 0.00158429826194362 4768 17201110
SGTC_1761 st044296 37 µM -3.05604751461058 0.000951178590883821 yes 3345 0.00112137855888672 4791 1826700
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -3.11629479672509 0.00077294028735675 yes 3346 0.000915695454625824 4809 4620898
SGTC_1037 k284-1091 78.7 µM -3.14250315463169 0.000705464594459064 yes 3347 0.000837549540554852 4760 3334711
SGTC_2561 acetosyringone 100 µM -3.19455409470454 0.000587277080632497 yes 3348 0.000700235182723868 4791 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3008 9078912 71.4286 µM -3.22303523337247 0.000530632824824193 yes 3349 0.000634199754506203 4795 16648731
SGTC_364 0083-0097 67.7 µM -3.28622359008393 0.000422535604444064 yes 3350 0.000507701876759369 4788 5207356
SGTC_997 3996-0078 137 µM -3.43760770211583 0.000241037036498359 yes 3351 0.000293438637436591 4805 735687
SGTC_41 0478-0632 82.643 µM -3.48005457901569 0.000205122143512145 yes 3352 0.000250655822607345 4791 3750424
SGTC_1211 1056-0033 32.3 µM -3.51613815434185 0.000178588373780604 yes 3353 0.000218936535541394 4806 6741922
SGTC_2697 mebhydrolin 72.4 µM -3.70142914634226 8.59675769228876e-05 yes 3354 0.00010719426274129 4795 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -4.05153038954994 1.97216707815682e-05 yes 3355 2.54418577688314e-05 4804 6708784 An antioxidant flavonoid
SGTC_2085 5307070 144.047 µM -4.3633172520012 4.80678423971214e-06 yes 3356 6.40524789791843e-06 4806 2840351