SGTCid condition conc unit LDH1|YBR204C.score LDH1|YBR204C.strain.pval LDH1|YBR204C.strain.significant LDH1|YBR204C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_2130 NSC 7 2.4545 µM 9.96485166734776 1.98711924796203e-25 yes 1 1.08598919623278e-23 2 21448 SGTC_360 0957-0399 1.01 µM 4.25557596055013 5.06511248734211e-06 yes 2 1.04255778640102e-05 37 6752301 YPR165W RHO1 SGTC_40 0327-0103 19.753 µM 4.2368947187758 5.54024666267317e-06 yes 3 1.13316167983405e-05 21 409036 SGTC_451 chloral hydrate 100 µM 4.05636923189223 1.29335474894466e-05 yes 4 2.49207233264202e-05 47 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1031 k035-0009 16 µM 4.03331320349886 1.43775373188406e-05 yes 5 2.74979502208426e-05 26 5180959 SGTC_844 0330-0132 15.3 µM 3.92605621581148 2.33550975127934e-05 yes 6 4.31749913598531e-05 16 2828079 SGTC_811 0416-0114 265 µM 3.92470730639526 2.34962526457296e-05 yes 7 4.34176264330244e-05 20 6612453 SGTC_213 1246-0773 967 nM 3.89171447071642 2.72114273371665e-05 yes 8 4.97691727307266e-05 23 6251622 SGTC_996 3970-0799 1.8 µM 3.52044195828828 0.00013139635396924 yes 9 0.000215414136379536 112 6615648 YGL040C HEM2 SGTC_304 1310-0298 97 µM 3.3663416497635 0.00024231013227309 yes 10 0.000380861508378269 88 1550234 SGTC_2690 usnic acid 100 µM 3.35589782019123 0.000252350085023509 yes 11 0.000395538953041705 53 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_769 0302-0231 76 µM 3.32594661346695 0.000283335356184378 yes 12 0.00044059402271729 82 571869 YER009W NTF2 SGTC_737 1950-0117 57.9 µM 3.2978423433466 0.000315598726504244 yes 13 0.000487154115269865 42 5393513 SGTC_1674 st016616 23.6 µM 3.29270171592815 0.000321857802370812 yes 14 0.000496148440642688 54 625830 SGTC_68 0986-0284 82.829 µM 3.22357421852987 0.0004180403589447 yes 15 0.000633007432185311 112 423278 YIL048W NEO1 SGTC_317 4495-0002 170 µM 3.21183596426905 0.000436808099918537 yes 16 0.000659448291648563 31 15991618 SGTC_519 k048-0011 62.8 µM 3.19533049342246 0.000464521802857312 yes 17 0.000698354001731882 53 6836379 SGTC_1177 0983-0204 23.6 µM 3.17737435271171 0.000496515757406218 yes 18 0.000743075350018777 37 766818 SGTC_2794 7785382 27.27 µM 3.15397516607104 0.000541271591166529 yes 19 0.000805313954882433 76 2205081 SGTC_790 1575-0012 79.1 µM 3.14095750883212 0.000567757942119997 yes 20 0.000841982310712436 63 378741 YLR208W SEC13 SGTC_361 000s-0510 1.45 µM 3.13647357464829 0.000577155154188833 yes 21 0.000854964227361967 71 660 SGTC_3162 9099653 49.47 µM 3.12196852728502 0.000608547725891583 yes 22 0.000898230712028936 18 25237511 SGTC_215 1287-0124 461.5 µM 3.00276050005532 0.000932887770818695 yes 23 0.00133771444815633 20 5560863 SGTC_1811 st050069 61.5 µM 2.94940204060181 0.00112423084839616 no 24 0.00159194745144766 23 3877702 SGTC_949 1165-0505 146 µM 2.88468954499492 0.00140426983483727 no 25 0.00195899911179766 84 6244267 SGTC_186 3455-3465 67.277 µM 2.86204476955037 0.00151642065063975 no 26 0.00210458722967646 16 755278 SGTC_181 1447-1644 8.07 µM 2.82677886147112 0.00170742465947141 no 27 0.00235093926895468 85 534600 SGTC_1264 0783-0040 158 µM 2.8264690783031 0.00170919543872603 no 28 0.00235321438840333 82 2855798 SGTC_252 miconazole 1.30953 nM 2.81826626310847 0.00175669678800024 no 29 0.00241418756577277 103 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1657 st012939 43.4 µM 2.81747768280654 0.00176132606089858 no 30 0.00242012391692944 50 24207257 SGTC_535 2293-4129 48.2 µM 2.80530602259186 0.00183420036574283 no 31 0.0025134414119447 143 396118 YIL048W NEO1 SGTC_1560 lithocholic acid 53.1 µM 2.77433332143129 0.00203216809306803 no 32 0.00276574855146226 31 9903 A bile acid which acts as a detergent. SGTC_150 3970-0969 77.2 µM 2.77041677955589 0.00205853666309123 no 33 0.00279923023062605 154 6615640 SGTC_1611 st001856 99.4 µM 2.72070155006284 0.00242131066409173 no 34 0.00325717731099488 80 647478 SGTC_1243 0416-0003 5.65 µM 2.68476678837219 0.00271853330292054 no 35 0.00362902154786388 112 2141977 SGTC_1987 st072290 61.9 µM 2.67245390222299 0.00282771398630009 no 36 0.00376493596875682 88 54697379 SGTC_999 SEC7.066 22.7 µM 2.66274417663704 0.00291658445889447 no 37 0.00387531569463738 109 740511 YDR170C SEC7 SGTC_1247 0448-0043 5.84 µM 2.6586828593046 0.00295449764941636 no 38 0.00392233837746575 147 3089013 YGL099W LSG1 SGTC_349 k015-0014 24 µM 2.64103692580025 0.00312443537870514 no 39 0.00413263552223311 112 2196908 SGTC_3313 9133968 57.047 µM 2.63600699453677 0.00317446154395156 no 40 0.00419440011588949 63 1494643 SGTC_1427 4048-4900 550 nM 2.6297422444653 0.00323777625830873 no 41 0.00427248142904822 95 24132586 SGTC_310 1273-0058 1.06 µM 2.62706035280863 0.00326522634404931 no 42 0.00430630284502843 409 2734232 SGTC_1563 conessine 56.1 µM 2.61773433038156 0.00336231837133527 no 43 0.00442578448724698 98 441082 An anti-amoebic, histamine inhibitor. SGTC_627 1391-0720 175 µM 2.61633469054433 0.0033771116913052 no 44 0.00444396949224196 81 997839 SGTC_2798 7813637 45.45 µM 2.59177263334875 0.00364641499952227 no 45 0.0047741426318825 123 956368 SGTC_3064 1327-0027 10 µM 2.58590466421852 0.00371353877700818 no 46 0.00485618950861925 40 16000455 YPR107C YTH1 SGTC_1465 k213-0056 144 µM 2.58311496023284 0.00374583723327008 no 47 0.00489563455982327 107 24048857 YMR208W ERG12 SGTC_1765 st044815 90.4 µM 2.50881512766647 0.00470415061313167 no 48 0.00605684322710696 113 645695 SGTC_869 0564-0080 44.1 µM 2.50641543396145 0.00473845586071434 no 49 0.00609811141452115 125 6843321 SGTC_2711 st079103 59.1 µM 2.43217398619066 0.00591619561777106 no 50 0.00750424796477569 86 54693780 SGTC_910 3454-3003 490 µM 2.40097619946104 0.00648408346745455 no 51 0.00817569998912453 139 820824 SGTC_673 1082-0474 110 µM 2.3940869814546 0.00661580277350084 no 52 0.00833089847528082 213 3098046 SGTC_1561 5-methoxyflavone 52.9 µM 2.3834611256721 0.0068236051533272 no 53 0.00857534789190206 62 94525 SGTC_1814 st052110 31.539 µM 2.36278040294269 0.00724463313419561 no 54 0.00906920696434435 103 674163 SGTC_2185 6113692 200 µM 2.35167837261569 0.00747997136905719 no 55 0.00934446334503827 115 874150 SGTC_3246 9135460 32.98 µM 2.35088919657405 0.0074969536916256 no 56 0.0093643049954083 75 41446951 SGTC_1620 st003704 16.5 µM 2.33578766022572 0.00782853227785542 no 57 0.00975115553302316 108 2834414 SGTC_566 0958-0068 16.5 µM 2.3352052026152 0.00784157552621421 no 58 0.00976635174447698 123 6815365 SGTC_2395 5646831 180.19 µM 2.33477234393717 0.00785128111423219 no 59 0.00977765834318728 155 6808628 SGTC_1261 0712-0010 12.7 µM 2.32412023678905 0.00809347642478577 no 60 0.010059525360351 158 2840123 SGTC_39 0986-0283 58.349 µM 2.29659356942256 0.00874999741884283 no 61 0.0108209829160978 193 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_895 0964-0006 13.7 µM 2.29161145947166 0.00887368782152735 no 62 0.0109640368139646 126 6738897 SGTC_1168 k815-0004 80.5 µM 2.28735009299209 0.00898069746024763 no 63 0.0110876984039219 127 642433 SGTC_2002 4023503 131 µM 2.28653174994357 0.00900137623791823 no 64 0.0111115844351135 191 4736863 YCR052W RSC6 SGTC_1084 voriconazole 435 nM 2.275304474975 0.00928931880964317 no 65 0.0114438355932046 152 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_151 3013-0144 2.285 µM 2.27460008122408 0.00930764992796761 no 66 0.0114649656205208 171 906558 YHR107C CDC12 SGTC_1808 st050063 61.5 µM 2.27456582288885 0.00930854227222373 no 67 0.0114659941473992 126 4011993 SGTC_2468 5987765 72.9 µM 2.27389804712864 0.00932595112262768 no 68 0.0114860585760038 121 26772094 SGTC_2521 angolensin 13.4 µM 2.25877773885296 0.00972783296114579 no 69 0.0119486069684208 129 821428 A flavenoid. SGTC_1379 2144-0755 36.5 µM 2.25238344751938 0.00990228797544913 no 70 0.0121490254155598 180 5392327 SGTC_2033 5192550 145 µM 2.25199417544708 0.00991299612392907 no 71 0.0121613200480595 144 182073 SGTC_191 3914-0123 66.505 µM 2.23132606535992 0.0104962495493486 no 72 0.0128297691614119 61 3144412 SGTC_2523 spermine 47.74 µM 2.21167972126122 0.0110781660541097 no 73 0.013494401322775 160 1103 A DNA binding polyamine. SGTC_2491 paeonol 100 µM 2.2099853820638 0.0111296415343384 no 74 0.0135530884107252 108 11092 Increases levels of cortical cytochrome oxidase. SGTC_1434 4073-0095 163 µM 2.20822233054677 0.0111834252449533 no 75 0.0136143892447553 135 24133745 SGTC_1971 st069429 63.5 µM 2.18916795829955 0.0117792684735903 no 76 0.01429231729967 129 1246522 YGL099W LSG1 SGTC_3164 9100705 49.47 µM 2.18363681586422 0.0119573104327952 no 77 0.0144944730109652 107 17174235 SGTC_556 4058-0063 51.5 µM 2.17122713473128 0.0123652781668528 no 78 0.0149570035812017 167 6615692 SGTC_2020 4017018 200 µM 2.15366676187044 0.0129631496856682 no 79 0.0156331572680968 177 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_302 1094-0063 18.9 µM 2.13730221528414 0.0135426445259226 no 80 0.0162867094012217 135 5440289 SGTC_2342 7990637 118.86 µM 2.13335635964869 0.0136856739066621 no 81 0.0164477520604423 205 2033102 YER133W GLC7 SGTC_1453 4237-0541 195 µM 2.1210238008019 0.0141411376997462 no 82 0.0169598997761629 186 739892 SGTC_1060 3448-7350 82 µM 2.11386997880027 0.0144112809007958 no 83 0.0172631869933631 200 570178 SGTC_3063 1327-0034 4 µM 2.11258786784513 0.0144601627015167 no 84 0.017318029010991 191 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3346 9158254 43.5805 µM 2.10081895826511 0.014915571774128 no 85 0.0178284307940791 189 17639500 SGTC_407 eburnamonine 100 µM 2.08785539050537 0.0154314290303591 no 86 0.0184054406224539 171 3195 SGTC_1305 1181-0477 144 µM 2.08630187652679 0.015494263654416 no 87 0.018475643403054 183 6252086 SGTC_3 0833-0587 95.581 µM 2.08153202817014 0.0156885627424762 no 88 0.0186926178294263 165 5382644 SGTC_2408 sulbentine 18.36 µM 2.07965431659445 0.0157656224706525 no 89 0.0187786255484879 226 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1700 st030840 7.9285 µM 2.07709993169323 0.0158709733805894 no 90 0.0188961684474755 195 5499307 SGTC_3312 9133330 71.43 µM 2.0696686905898 0.0161809003544902 no 91 0.0192416903275407 171 17617324 SGTC_1376 2910-0861 41.3 µM 2.06812013636788 0.0162461330857983 no 92 0.019314363824319 227 1112859 SGTC_1605 st000082 49.1 µM 2.05660520640934 0.0167383009936455 no 93 0.0198621085097425 188 1114022 SGTC_632 0781-2353 4.65 µM 2.05588533035451 0.0167694889034542 no 94 0.0198967852199399 244 6811515 YHR007C ERG11 SGTC_2716 st080858 38.6235 µM 2.05235052511567 0.0169233530764731 no 95 0.0200678045162525 177 5296050 SGTC_2861 9024595 19.48 µM 2.04872212946931 0.0170825449547238 no 96 0.0202446470096908 89 16482810 SGTC_58 0957-0393 9 µM 2.04533701574608 0.017232215387341 no 97 0.020410821890969 660 6997992 SGTC_715 0868-0130 184 µM 2.04170873822913 0.0173938796861931 no 98 0.0205902157351912 171 2876258 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 2.03412921332242 0.0177357814139543 no 99 0.0209692846182118 219 688751 SGTC_2693 st077581 40.7 µM 2.03411784281821 0.0177362985982419 no 100 0.0209698576895079 291 25238761 SGTC_736 0958-0254 92.6 µM 2.03082079712802 0.0178868076514569 no 101 0.0211365882697471 240 6812352 SGTC_1980 st071811 45.7 µM 2.01984670576504 0.018395642464793 no 102 0.0216996453859888 198 4974850 SGTC_1300 1094-0077 113 µM 2.01282472109934 0.0187276575999547 no 103 0.0220665361226442 196 5532636 SGTC_551 k048-0028 34.9 µM 2.01165884772278 0.01878327343748 no 104 0.0221279557166342 225 6836383 SGTC_909 3448-9333 149 µM 2.01105177294385 0.0188122884206806 no 105 0.0221599942196615 189 3344074 SGTC_397 arbidol 50 µM 2.00831967082422 0.0189433410034381 no 106 0.0223046664438312 224 131410 A RNA synthesis inhibitor. SGTC_1654 st012436 41.8 µM 2.0081283880251 0.01895254541065 no 107 0.022314825164867 175 4323132 SGTC_1792 st045773 43.6 µM 1.99840495699617 0.0194254682687012 no 108 0.0228363873329393 230 2919270 SGTC_1188 1403-0014 4.57 µM 1.99371329067121 0.0196572214295267 no 109 0.0230916980450805 295 9614867 SGTC_1329 1447-1697 50.6 µM 1.99178193195514 0.0197533041678709 no 110 0.0231974947568796 231 2840515 SGTC_2096 5468907 200 µM 1.99176704114477 0.0197540465134374 no 111 0.0231983120339854 190 759785 SGTC_2239 6685329 187.64 µM 1.9889372116838 0.0198955513916048 no 112 0.0233540668983511 236 805680 SGTC_1104 tacrolimus 29.8 µM 1.97204383812705 0.0207583122011458 no 113 0.0243023011598082 232 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_3252 9135871 49.47 µM 1.97155881400923 0.0207835435174277 no 114 0.0243299963809824 202 17682838 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.96317696291096 0.0212236921173191 no 115 0.0248128076014156 318 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_533 1222-0222 6.71 µM 1.96302641606201 0.021231669173921 no 116 0.0248215523352552 247 3982874 SGTC_1527 coumarin 137 µM 1.96059250248573 0.0213609877646476 no 117 0.0249632888435843 231 323 A hepatotoxic, DNA x-linker. SGTC_2906 7926292 26.41 µM 1.95662839462777 0.0215730340512946 no 118 0.0251955870650701 243 2966319 SGTC_1523 st012844 44.7 µM 1.95455105326096 0.0216848628211632 no 119 0.0253180416904754 237 4274103 SGTC_321 4534-3890 65.3 µM 1.94790861860168 0.0220457347071259 no 120 0.0257129491794161 182 699746 SGTC_1514 1189-1591 158 µM 1.94569904487031 0.0221668951256549 no 121 0.0258454507301363 293 767698 YMR146C TIF34 SGTC_2215 7188065 200 µM 1.93843806984219 0.0225690100904137 no 122 0.026284899794007 164 940217 SGTC_2437 5741531 144.16 µM 1.92192660196729 0.0235063592782021 no 123 0.0273074969934101 259 2262990 SGTC_3295 9122362 53.5725 µM 1.91647255739278 0.0238230912328215 no 124 0.0276524865050328 217 4730473 SGTC_56 0957-0365 83.25 µM 1.90963611762983 0.0242251624188098 no 125 0.0280900406989028 279 6752360 SGTC_1722 st034304 3.6505 µM 1.902770906132 0.0246346456437641 no 126 0.0285352225488066 273 4036148 YLR033W RSC58 SGTC_911 3456-4043 236 µM 1.90039430803608 0.0247777470279837 no 127 0.0286906966629688 287 914281 SGTC_772 k072-0172 35.3 µM 1.89869555235947 0.0248804604675586 no 128 0.0288022583423871 228 5861980 SGTC_1468 k284-1086 134 µM 1.89511493687646 0.0250981283641831 no 129 0.0290385880954471 317 15996457 SGTC_2341 7987486 176.74 µM 1.89497822028027 0.0251064709898481 no 130 0.0290476435821868 273 1258686 SGTC_479 n-linoleoylglycine 10 µM 1.87971607030714 0.0260525105235452 no 131 0.0300733921075107 204 6433346 An anti-infammatory. SGTC_593 1203-0218 61.7 µM 1.86572521962522 0.0269457647887758 no 132 0.0310399096793904 260 3666956 SGTC_868 0527-0199 213 µM 1.86551883060514 0.0269591308121714 no 133 0.0310543576149399 278 2849450 SGTC_2297 7971671 152.32 µM 1.86288442551925 0.0271302250278792 no 134 0.0312392642438653 264 909016 SGTC_520 3584-0023 682 µM 1.861716347266 0.0272063765151796 no 135 0.0313215415563588 263 1340790 SGTC_1572 epiandrosterone 68.9 µM 1.85916778114775 0.0273731463979528 no 136 0.0315016800509044 268 441302 A steroid. SGTC_3254 9136651 49.47 µM 1.8546307014489 0.0276721478498413 no 137 0.0318244904064632 277 16454030 SGTC_293 4049-0273 38.5 µM 1.84513578939789 0.0283066928793735 no 138 0.0325088940835033 228 1380311 SGTC_1139 k015-0024 46.9 µM 1.8299536778384 0.0293464484088634 no 139 0.0336284329013132 233 2766652 SGTC_411 enrofloxacin 100 µM 1.82683024327714 0.0295642456092619 no 140 0.0338626485659751 241 71188 A bacterial gyrase inhibitor. SGTC_943 3253-1379 105 µM 1.82661921609288 0.0295790087995153 no 141 0.0338785210463026 281 668464 SGTC_1008 4106-0037 6 µM 1.82359745026492 0.0297910795994051 no 142 0.0341064761715459 242 2905394 SGTC_3280 9140961 49.47 µM 1.81939002972732 0.0300884604618348 no 143 0.0344259733664067 227 4901226 SGTC_1057 3448-5381 134 µM 1.8177972133903 0.030201681221972 no 144 0.0345475663588578 295 5497911 SGTC_209 4077-0173 175.592 µM 1.81193912250901 0.0306211286031382 no 145 0.0349978017576306 183 15993494 SGTC_1553 gossypol 38.6 µM 1.80773972179309 0.0309247708942109 no 146 0.0353235096289044 151 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_542 3381-0244 89.3 µM 1.80298196019922 0.0312717927162416 no 147 0.0356955239301984 324 1112843 SGTC_2920 7982904 15.77 µM 1.79345363631137 0.0319764557842437 no 148 0.0364502088933766 271 6456808 SGTC_3068 9116768 49.47 µM 1.79260770380998 0.0320396451454925 no 149 0.0365178368604622 275 41904888 SGTC_848 0368-0089 85.6 µM 1.79200769971789 0.0320845266492024 no 150 0.0365658663182428 289 762535 SGTC_3061 glucosamine 200 µM 1.7827406993175 0.032784333179739 no 151 0.0373142614429777 246 91431 and experimental redox chemotherapeutic SGTC_3021 9087658 49.47 µM 1.78237473908392 0.0328122252944959 no 152 0.0373440710326815 215 25237042 SGTC_946 3434-1334 87.4 µM 1.78076588607868 0.0329350781696673 no 153 0.0374753522995554 284 4047976 SGTC_1357 1503-1303 39.5 µM 1.77828523891374 0.0331252444136988 no 154 0.037678509723776 330 292895 SGTC_2740 felodipine 17.08 µM 1.77597191503103 0.0333033979174858 no 155 0.0378687731637528 220 3333 L-type calcium channel blocker SGTC_1549 4'-methoxyflavonol 74.6 µM 1.77406721397717 0.0334506742446477 no 156 0.0380260165621071 265 97141 SGTC_2080 5212524 12.4 µM 1.76856219875191 0.0338793530093419 no 157 0.0384834818856428 253 260183 SGTC_1422 4031-0024 15.5 µM 1.76848768861642 0.0338851860086058 no 158 0.038489704290046 282 782427 SGTC_1045 1348-1485 165 µM 1.76586757496498 0.0340908265145875 no 159 0.0387090341172446 355 6810614 SGTC_29 0299-0004 12.984 µM 1.75963133073204 0.0345844101220075 no 160 0.0392351678678764 217 16871 A napthoquinone isolated from Swertia calycina. SGTC_991 3996-0057 64.7 µM 1.75315845277278 0.0351029157666778 no 161 0.0397874061939415 295 715343 SGTC_567 1080-0542 68.4 µM 1.74143589802715 0.0360581733464455 no 162 0.0408036001722361 263 5950415 SGTC_3008 9078912 71.4286 µM 1.72913273837156 0.037083534870177 no 163 0.0418926705095828 278 16648731 SGTC_65 0798-0905 34.986 µM 1.72422822691952 0.0374988716164007 no 164 0.0423333251644505 447 3602145 SGTC_1813 st051246 8.6015 µM 1.72352852400522 0.0375584341519878 no 165 0.0423964957653409 251 5291959 SGTC_208 k072-0098 12.366 µM 1.71744648186595 0.0380794313892007 no 166 0.0429488124913395 397 5948901 SGTC_2397 5161689 200 µM 1.71290090749195 0.0384726494452921 no 167 0.0433653856555885 341 2259942 SGTC_1946 st076057 65.1 µM 1.70938018608619 0.0387794809715166 no 168 0.0436902743579954 190 953009 SGTC_1911 st060208 74.3 µM 1.70861325212318 0.0388465831162929 no 169 0.0437613061336105 340 688783 SGTC_696 1560-0013 611 µM 1.70172486052052 0.0394535248231663 no 170 0.0444034789040497 321 1650269 SGTC_1189 1431-2119 7.28 µM 1.69316118648469 0.0402188098700576 no 171 0.0452123951576591 375 3107275 SGTC_638 3970-0837 4.09 µM 1.68535843754593 0.0409265525970176 no 172 0.045959718683341 343 4118451 YLR208W SEC13 SGTC_603 3794-0023 45.9 µM 1.67635427675787 0.0417557887769828 no 173 0.0468344096520422 287 3802260 SGTC_2050 5263056 171 µM 1.67153890043633 0.0422048134945765 no 174 0.0473076408664448 401 763468 YGL055W OLE1 SGTC_2524 avocatin b 10.57 µM 1.66696853452134 0.0426345977906218 no 175 0.0477603308755065 296 6710748 SGTC_2336 9001819 198.65 µM 1.6631657257868 0.0429948941687657 no 176 0.0481396331609824 392 2989602 SGTC_1715 st032160 10.2275 µM 1.65899066010941 0.0433932888588765 no 177 0.0485588371845707 325 5289825 SGTC_1283 0922-0125 16.4 µM 1.65779411216605 0.043508014163774 no 178 0.0486795150702676 362 3360884 SGTC_742 0kpi-0133 140 µM 1.65693349093236 0.0435906820120117 no 179 0.0487664611913217 352 2728852 SGTC_2119 5528445 120.635 µM 1.6536769991062 0.043904635630054 no 180 0.0490965792277116 337 791935 SGTC_2928 9011484 9.79 µM 1.64976699127737 0.0442840005418262 no 181 0.0494953012340903 315 2994751 SGTC_1292 0kpi-0043 232 µM 1.64767912469916 0.0444876533433872 no 182 0.0497092669862448 340 3333905 SGTC_1352 1496-0991 99 µM 1.64058373870963 0.0451853902818947 no 183 0.0504419264010064 343 3000039 SGTC_577 r071-0003 38.6 µM 1.6367997486095 0.0455610798860686 no 184 0.0508361591509651 489 4568517 YMR134W ERG29 SGTC_37 0566-0070 1.56 µM 1.63286866844836 0.0459540288658176 no 185 0.0512483104927767 388 1626686 SGTC_295 k015-0027 31 µM 1.63105019720853 0.0461367212589557 no 186 0.0514398640323854 324 3887424 SGTC_2084 5306078 60.6385 µM 1.63089111050445 0.0461527315864697 no 187 0.0514566489075647 352 679340 SGTC_425 3825-7017 13.1 µM 1.62860890530608 0.04638290196792 no 188 0.0516979189294022 397 3397440 SGTC_3069 9117009 49.47 µM 1.62810297836117 0.0464340514956307 no 189 0.0517515260673018 237 41904981 SGTC_1396 3511-0007 98.6 µM 1.62436234155559 0.0468136385740737 no 190 0.0521492496460653 315 X1396 SGTC_545 4218-0007 221 µM 1.61838187095962 0.0474256833261145 no 191 0.0527901632595802 343 2840508 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.61799200415349 0.0474658040823544 no 192 0.0528321604261197 354 688669 SGTC_2288 7946289 167.31 µM 1.61369970499198 0.0479093198241814 no 193 0.0532962889913267 423 1246052 SGTC_106 0092-0003 11.579 µM 1.61320068371891 0.0479610973794865 no 194 0.0533504574851608 275 1072148 SGTC_1351 1496-0003 46.5 µM 1.60601224119721 0.0487119383389201 no 195 0.0541356101841932 369 3891978 SGTC_1693 xanthone 101.9 µM 1.59125427048611 0.050282859723206 no 196 0.0557761818608317 379 7020 An insecticide. SGTC_1059 3448-6867 171 µM 1.59033900595458 0.0503816001647785 no 197 0.0558792054184808 371 3934407 SGTC_256 clotrimazole 625 nM 1.59009719595851 0.0504077128635557 no 198 0.0559064489725118 379 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3257 9139206 32.98 µM 1.58960949022708 0.0504604122835301 no 199 0.0559614282790827 280 4910041 SGTC_1320 1313-0481 95.3 µM 1.58747346822326 0.0506917391344976 no 200 0.0562027256898546 366 6813365 YLR208W SEC13 SGTC_938 3126-1755 342 µM 1.5841179218145 0.0510568426691909 no 201 0.0565834433627556 377 1777771 SGTC_69 0096-0274 206.684 µM 1.58342423631169 0.0511325802215556 no 202 0.0566624012607339 454 6741392 SGTC_839 0122-0028 230 µM 1.5814566305536 0.051347892677803 no 203 0.0568868338918692 449 759448 SGTC_223 busulfan 5 mM 1.58003335140137 0.0515040892523765 no 204 0.0570496144428194 286 2478 A DNA alkylator. SGTC_405 ebelactone b 50 µM 1.57733038699821 0.0518017637754865 no 205 0.0573597619691897 396 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.56651063606587 0.0530070458052526 no 206 0.0586145602764393 338 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1017 4239-0030 168 µM 1.562829786094 0.053422112670643 no 207 0.0590463180945098 427 1149593 SGTC_585 0kpi-0023 191 µM 1.56241123241279 0.0534694730393305 no 208 0.0590955713369393 349 64601 SGTC_1847 st056231 15 µM 1.55933558280496 0.0538185114797539 no 209 0.0594584870268685 468 5393180 SGTC_2186 6124449 200 µM 1.55163024862493 0.0547008710887288 no 210 0.0603753605577417 374 3834182 YLR033W RSC58 SGTC_1596 piperlongumine 63 µM 1.54760373129736 0.0551664876891948 no 211 0.060858866255996 415 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2959 9079155 11 µM 1.54566178487088 0.0553921659314781 no 212 0.0610931355547548 343 16189457 SGTC_1102 cgs 12066b 26.1 µM 1.54464048837731 0.0555111454056523 no 213 0.0612166235171547 347 6438352 A 5-HT1B full agonist. SGTC_1477 0139-0234 16 µM 1.54241137265298 0.0557715346713772 no 214 0.0614868298474878 368 620880 SGTC_297 0986-0032 24 µM 1.53881191392906 0.0561940311144403 no 215 0.0619251102303978 340 2847425 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.5296421659639 0.0572817619912853 no 216 0.0630526631268703 307 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_216 k038-0035 28.382 µM 1.52886046199265 0.0573752502200151 no 217 0.0631495198519667 361 4444231 YPR107C YTH1 SGTC_2245 6637752 200 µM 1.5264795783008 0.0576607328292822 no 218 0.0634452362657195 327 681890 SGTC_2443 5493264 126.67 µM 1.51823346120522 0.0586581346833768 no 219 0.0644777774651553 397 5340055 SGTC_3286 9117135 37.221 µM 1.51578984240475 0.0589562873253788 no 220 0.0647862506594819 415 3438150 SGTC_922 1866-0035 480 µM 1.51471145237688 0.0590882422150106 no 221 0.0649227464479381 488 3156169 SGTC_780 0109-0199 192 µM 1.51322530698645 0.0592704706955909 no 222 0.0651112190254625 452 610414 SGTC_311 1315-0136 58 µM 1.51045543692092 0.0596112829531324 no 223 0.0654636260802015 392 6759207 SGTC_1692 fluoroquinolonic acid 71 µM 1.50863243294245 0.059836426961715 no 224 0.0656963705498969 371 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_486 niguldipine 82 µM 1.5061167884792 0.0601482063688486 no 225 0.0660185977835595 356 1236 A calcium channel blocker. SGTC_2496 diffractaic acid 79.83 µM 1.50218080803629 0.0606385667822593 no 226 0.0665252099572434 458 94870 An apoptosis inducer which activates caspases. SGTC_34 0469-0683 81.75 µM 1.50142734198587 0.0607327922570283 no 227 0.0666225331883133 387 3690923 SGTC_204 PMA1.184 62.41 µM 1.49673441190396 0.0613222515176801 no 228 0.0672311892145661 476 2252213 YGL008C PMA1 SGTC_1049 3226-0134 66 µM 1.49667462239231 0.0613297901608365 no 229 0.0672389713401809 458 5702385 SGTC_944 3370-0224 231 µM 1.49347518718691 0.0617342523834569 no 230 0.0676564223030063 418 4580514 SGTC_3235 9132602 49.47 µM 1.48795487131532 0.0624370054314375 no 231 0.06838139770808 462 4912240 SGTC_57 miconazole 162.5 nM 1.48704009686653 0.0625540591182713 no 232 0.0685021105668421 401 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_823 0417-1665 178 µM 1.48697660527619 0.0625621897876035 no 233 0.0685104949599178 429 3429856 SGTC_332 4112-0506 40.9 µM 1.48263381330797 0.0631202811949976 no 234 0.0690858641414323 426 2790355 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.48195923565341 0.0632073178739412 no 235 0.0691755709611591 422 6708760 SGTC_182 3448-4371 550.524 µM 1.48160805821111 0.0632526651503864 no 236 0.0692223068194784 446 3491403 SGTC_831 k061-1017 217 µM 1.48052145903982 0.0633931373307355 no 237 0.0693670691340135 602 1240153 SGTC_500 h-89 112 µM 1.47834704100399 0.0636749684272248 no 238 0.0696574563293817 471 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_2644 guaiazulene 100 µM 1.47445829060952 0.0641814273769592 no 239 0.0701791199337213 389 3515 A coloring agent. SGTC_1418 3966-3099 2.4 µM 1.47119056531007 0.0646094222885712 no 240 0.0706197939825899 467 740335 SGTC_1812 st052057 4.327 µM 1.47000628680364 0.0647650809773911 no 241 0.0707800256488569 447 3645418 SGTC_982 1491-0518 27.5 µM 1.46698298751828 0.0651637767126899 no 242 0.0711903416716909 402 3091256 SGTC_3150 9097574 49.47 µM 1.46665727121473 0.0652068437482373 no 243 0.0712346559792184 383 17217476 SGTC_2398 5228213 48.84 µM 1.46512659144004 0.0654095299313991 no 244 0.071443191463401 535 80771 YMR134W ERG29 SGTC_93 0109-0045 59.227 µM 1.46269648649498 0.0657323175149975 no 245 0.0717752240026017 552 88733 SGTC_3340 9146634 11.102 µM 1.4578931635023 0.0663739674797234 no 246 0.072434996658565 441 4907387 SGTC_492 tmb-8 126 µM 1.45735636977815 0.0664459751044792 no 247 0.0725090170336652 274 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2575 plumbagin 510 nM 1.45722825791198 0.0664631694713869 no 248 0.0725266913911643 444 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_59 0330-0160 1.33 µM 1.45658792247631 0.0665491628983149 no 249 0.0726150817633356 614 4293482 SGTC_180 1486-1293 102.781 µM 1.45313164849987 0.0670148087530157 no 250 0.0730936026820655 439 4140536 SGTC_1499 4480-0877 67.3 µM 1.45305580659384 0.0670250547221213 no 251 0.0731041299808375 387 2861909 SGTC_2608 thymoquinone 42.66 µM 1.45134583431822 0.0672563875865552 no 252 0.0733417922019814 394 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1791 st048313 56.1 µM 1.45046600089848 0.0673756557407058 no 253 0.0734643067895838 390 1204976 SGTC_820 1582-0060 59.9 µM 1.44888713332326 0.0675900931510171 no 254 0.0736845524697065 477 3848840 SGTC_2585 alliin 100 µM 1.44875022311279 0.0676087127337398 no 255 0.0737036746512652 484 87310 A garlic compound which reacts with lipids. SGTC_1634 st006576 41 µM 1.44836293054048 0.0676614054031592 no 256 0.0737577881572787 446 3915356 SGTC_660 4031-1742 102 µM 1.44829860957351 0.0676701595936369 no 257 0.0737667781866513 505 6738706 SGTC_3174 9107204 49.47 µM 1.4446389437057 0.0681696888610488 no 258 0.0742796640053284 455 3938802 SGTC_1603 st002045 67.8 µM 1.44283940967164 0.0684163593859093 no 259 0.0745328573103262 447 5887985 SGTC_618 k072-0232 33.2 µM 1.44083261962256 0.0686922510269653 no 260 0.07481598778574 429 5872756 YGL099W LSG1 SGTC_381 3461-2219 42.7 µM 1.43878979956631 0.0689739764345645 no 261 0.0751050436601517 467 2883159 SGTC_892 0929-0076 29 µM 1.43702502696069 0.0692180725866197 no 262 0.0753554412130727 516 5751038 SGTC_1640 st009078 66.4 µM 1.43623653037913 0.0693273491013511 no 263 0.0754675237535331 386 690618 SGTC_1873 rapamycin 2 nM 1.43117681138434 0.0700317327097999 no 264 0.076189773804387 523 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2121 5257820 149.641 µM 1.42776856812818 0.0705093027584037 no 265 0.0766792413456582 485 791256 SGTC_1040 k898-0338 155 µM 1.42305411435108 0.0711740232035744 no 266 0.0773602343387193 507 20969351 SGTC_1908 st060353 56.5 µM 1.4227349390185 0.0712191990540012 no 267 0.0774065040534597 516 4227716 SGTC_3207 9114163 49.47 µM 1.42244971200592 0.0712595885073496 no 268 0.077447870182488 523 849233 SGTC_1395 3486-0190 4.35 µM 1.4211089743018 0.0714496787529777 no 269 0.0776425407163929 491 6748079 SGTC_225 nsc-122657 1.016 µM 1.41927619550529 0.0717101600351678 no 270 0.0779092546520995 315 275685 SGTC_1951 sophoraflavanone G 9.2 µM 1.4160326879246 0.0721729237734315 no 271 0.0783829670874894 518 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2243 6634756 200 µM 1.4153128685388 0.0722759328614667 no 272 0.0784883918037722 418 885676 SGTC_3211 9128781 49.47 µM 1.41477979556072 0.0723522903636719 no 273 0.0785665349030512 487 17194361 SGTC_2457 5731572 11.68 µM 1.41088215368339 0.0729124689701646 no 274 0.079139682585079 456 2865357 SGTC_1773 st048542 73.5835 µM 1.40920111762133 0.0731550938573105 no 275 0.0793878536935927 493 3237138 SGTC_417 st075190 100 µM 1.40617347362471 0.0735936330395641 no 276 0.0798363094899298 491 222757 SGTC_723 4182-0001 115 µM 1.40597615451356 0.0736222833483697 no 277 0.0798656028405429 446 744821 YLR208W SEC13 SGTC_701 4424-0219 185 µM 1.40393517964701 0.0739191289582604 no 278 0.0801690763341789 534 2911779 SGTC_183 3914-0051 30.55 µM 1.40217770585265 0.0741754734094213 no 279 0.0804310936555029 475 1596232 SGTC_2905 7799065 20.05 µM 1.40196946934631 0.074205891643568 no 280 0.0804621819317783 434 1296806 SGTC_1098 clofazimine 15.1 µM 1.40054088698805 0.0744148293400134 no 281 0.0806757042549182 535 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_1145 3546-0597 10.2 µM 1.39716629645086 0.074910164324071 no 282 0.0811817846341381 505 875334 SGTC_501 nsc-95397 161 µM 1.39116043901728 0.075797942306493 no 283 0.0820883903543936 449 262093 SGTC_2746 daunorubicin 9.88 µM 1.3788193660846 0.0776473042598874 no 284 0.083975227087452 320 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1660 st012960 28.1 µM 1.37655377342282 0.0779905036053814 no 285 0.0843251256114937 497 24207266 SGTC_1897 st060201 15 µM 1.37587172382442 0.0780940477706151 no 286 0.0844306754347208 451 611878 SGTC_1406 3909-7906 11.9 µM 1.37525434402754 0.0781878640954627 no 287 0.084526302801211 503 X1406 SGTC_1388 3346-4487 254 µM 1.37460842445564 0.0782861087684843 no 288 0.0846264377056171 544 3345614 SGTC_307 1501-1223 22.3 µM 1.37195193234637 0.0786911469083763 no 289 0.0850392009946589 491 2830329 SGTC_1370 2001-0092 44.6 µM 1.37082470336935 0.0788634958193784 no 290 0.0852148040747769 577 790957 SGTC_534 k292-0788 63.4 µM 1.36886918088707 0.0791631657311716 no 291 0.0855200854750502 557 4146317 SGTC_1606 st000094 49.2 µM 1.36514155667847 0.079736784727027 no 292 0.0861042814493179 521 1242210 SGTC_2328 6201408 200 µM 1.35824120899147 0.0808069215924971 no 293 0.087193579229424 491 2890418 SGTC_511 blebbistatin 171 µM 1.35610108960927 0.0811410143608777 no 294 0.0875335031249121 493 3476986 A myosin inhibitor. SGTC_76 0433-0009 400.328 µM 1.35579369564076 0.0811890869354126 no 295 0.087582408876758 422 2841569 SGTC_1234 0326-0494 15.5 µM 1.35551095678105 0.0812333227297298 no 296 0.0876274100503503 493 1547813 SGTC_3289 9119912 71.43 µM 1.35167068663603 0.0818359527363327 no 297 0.088240343224307 496 17014829 SGTC_2316 5844804 197.44 µM 1.35148974363967 0.0818644299063421 no 298 0.0882693015853868 628 776813 SGTC_1781 st038725 66.3 µM 1.35116533755523 0.0819155042801707 no 299 0.0883212377046394 609 4270275 YIL048W NEO1 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.35020047820231 0.0820675532975811 no 300 0.0884758424271613 553 1377 SGTC_107 0358-0022 2.6945 µM 1.35016741954124 0.0820727666682681 no 301 0.0884811431686306 359 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_734 2023-0417 80 µM 1.34874795137459 0.0822968530789983 no 302 0.0887089689142642 522 3935732 SGTC_105 0111-0055 734.78 µM 1.3484964528717 0.0823366042616076 no 303 0.088749380138894 411 5179370 SGTC_983 1491-0821 12.2 µM 1.34834077495869 0.0823612175413092 no 304 0.0887744016100147 474 46495113 SGTC_1123 mangostin 811.285 nM 1.34522528458365 0.0828549542150341 no 305 0.0892762466435462 529 5281650 An antioxidant. SGTC_192 3455-0609 60.9 µM 1.3449714174379 0.082895284482383 no 306 0.0893172325295653 504 3769639 SGTC_2754 granisetron 64.02 µM 1.33710573565917 0.0841521849462082 no 307 0.0905940626154329 547 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_748 act1.228 77.9 µM 1.33507046224623 0.0844797304020094 no 308 0.0909266429179711 580 4421505 YNR035C ARC35 SGTC_3247 9135149 49.47 µM 1.33437159977978 0.0845924217184824 no 309 0.0910410514129124 458 8934436 YOR116C RPO31 SGTC_815 1582-0027 36.9 µM 1.33122023616292 0.085101978838087 no 310 0.0915582773739288 536 3128206 SGTC_1709 st033179 39.1045 µM 1.33020904761436 0.0852659686307951 no 311 0.0917247019931162 540 573381 SGTC_3197 9113331 49.47 µM 1.32897387525755 0.0854666041478372 no 312 0.0919282945217968 536 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_2469 5655019 90.81 µM 1.32745772590425 0.0857133633562392 no 313 0.092178657558891 547 2788239 SGTC_3129 9127257 49.47 µM 1.32626919500281 0.0859071740197585 no 314 0.0923752733404755 445 837894 SGTC_2564 betulinic acid 100 µM 1.32054042291903 0.0868459522138165 no 315 0.093327324565197 589 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_1199 1638-0010 4.46 µM 1.32029422816519 0.0868864674354421 no 316 0.0933684009516242 570 3111136 SGTC_773 4358-1457 44.6 µM 1.31830856033605 0.0872137567053526 no 317 0.0937001882441455 598 1186886 SGTC_1903 st060211 78.3 µM 1.31758618986612 0.0873330500675941 no 318 0.0938211055591079 568 688960 SGTC_512 prima-1 270 µM 1.31711167133576 0.0874114790456574 no 319 0.0939005976905261 565 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1293 1000-1278 195 µM 1.31425209556576 0.0878852264095849 no 320 0.0943806911860565 541 678847 SGTC_3103 9120822 49.47 µM 1.31292616754232 0.0881055422802571 no 321 0.094603914171142 561 17141819 SGTC_1986 st071812 45 µM 1.30900819490375 0.0887589573554444 no 322 0.0952657874171224 490 11838594 SGTC_1385 3091-4834 14.1 µM 1.30897723446712 0.0887641350760289 no 323 0.0952710311868582 503 4072814 SGTC_1779 st039427 55 µM 1.30791468419957 0.088941968800221 no 324 0.0954511241710511 622 1124498 SGTC_957 1187-1561 14.1 µM 1.30626524330786 0.0892185527005583 no 325 0.0957311862016264 557 1538454 SGTC_870 0573-2213 57.6 µM 1.30449700362902 0.0895157674240276 no 326 0.0960320902442711 512 3916321 SGTC_1033 k072-0102 21.3 µM 1.29921833381991 0.0904074127476528 no 327 0.0969345056870124 561 5965931 SGTC_2155 5570423 76 µM 1.29829091912607 0.0905647455615275 no 328 0.0970936928311861 525 797402 SGTC_472 calcifediol 10 µM 1.2977451274669 0.0906574322548154 no 329 0.0971874654972721 463 5283731 A vitamin D metabolite. SGTC_1217 1183-1422 255 µM 1.29525145272867 0.09108180553658 no 330 0.0976167502401769 578 2849664 SGTC_1590 st077108 57.8 µM 1.29502571469976 0.0911202942112266 no 331 0.0976556794418828 529 5489485 SGTC_172 1112-0046 2.638 µM 1.29384832534617 0.0913212364121297 no 332 0.0978589083074691 487 2802135 YIL048W NEO1 SGTC_1684 st024538 14.6195 µM 1.29016959048177 0.0919511938721677 no 333 0.0984958909814063 549 6732859 SGTC_3278 9139605 49.47 µM 1.29013081950953 0.0919578502225005 no 334 0.0985026204051814 543 7958859 SGTC_2724 maprotiline 69.64 µM 1.29009462204174 0.0919640650657319 no 335 0.0985089034532041 558 4011 A tricyclic antidepressant. SGTC_2152 5568786 200 µM 1.28771564272981 0.0923732008834859 no 336 0.0989224831432703 540 5399883 SGTC_2415 st077333 57.7 µM 1.28752857748607 0.0924054293129576 no 337 0.0989550577669827 646 2766255 SGTC_1506 4226-2149 212 µM 1.28364533017539 0.0930763326934868 no 338 0.0996330406133752 614 991114 SGTC_382 3229-0966 23.2 µM 1.28317507229953 0.0931578222758713 no 339 0.0997153735983375 587 5722370 SGTC_777 1315-0167 517 µM 1.28118860792049 0.0935026325551922 no 340 0.100063713273125 531 4221767 SGTC_2190 6049624 200 µM 1.28045855850035 0.0936295910343405 no 341 0.100191955283655 479 2265554 SGTC_827 3253-0474 693 µM 1.28045223769425 0.0936306908030303 no 342 0.100193066133336 598 5402065 SGTC_598 3937-0236 20.2 µM 1.2785347671664 0.0939647555335913 no 343 0.100530467059816 621 1379313 SGTC_2516 gossypol 71.55 µM 1.26938915726952 0.0955702262119242 no 344 0.102151150713689 607 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_163 TUB2.036 7.546 µM 1.26897065009042 0.0956441733166801 no 345 0.102225766097364 750 15992207 YJR013W GPI14 SGTC_2669 eugenol 100 µM 1.2675577896783 0.0958941262078411 no 346 0.102477956921902 500 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.26384495284281 0.0965532635933941 no 347 0.103142841421704 499 17037758 SGTC_1941 st076221 61.8 µM 1.26279188340185 0.0967408187871626 no 348 0.10333199121104 627 2828568 SGTC_1487 3970-0795 2.82 µM 1.26190039944503 0.0968998040806618 no 349 0.103492314132032 602 3765103 SGTC_2709 st078560 56 µM 1.25980490073466 0.0972742659695642 no 350 0.103869875728192 564 17250903 SGTC_1330 1469-0054 61.8 µM 1.25938338183767 0.0973497187440248 no 351 0.10394594446627 574 7102664 SGTC_1924 st058459 75.1 µM 1.25829948839102 0.0975439351007302 no 352 0.104141733064515 546 688683 SGTC_758 0868-0029 16 µM 1.25760272500079 0.0976689339038921 no 353 0.104267733689792 575 762687 SGTC_846 0335-0850 148 µM 1.25662313586374 0.0978448699986084 no 354 0.104445066502695 536 6819598 SGTC_12 0849-0099 9.267 µM 1.25620408627776 0.0979202030118498 no 355 0.104520992803727 556 6071388 SGTC_1876 myriocin 605 nM 1.25615450685955 0.0979291187707877 no 356 0.104529978590184 566 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_3230 9131665 49.47 µM 1.25353937435107 0.0984002360459114 no 357 0.105004739465099 440 15943720 SGTC_2551 apiole 73.87 µM 1.25285098061146 0.0985245259758429 no 358 0.105129972135687 415 10659 A possible DNA adduct former. SGTC_1257 0669-0121 16 µM 1.25205873055475 0.0986677094398108 no 359 0.105274232098482 644 4307855 SGTC_1286 0929-0070 131 µM 1.24793720644039 0.0994150507310724 no 360 0.106027026919715 620 1420408 SGTC_2337 9009472 200 µM 1.24746639586257 0.0995006837653477 no 361 0.106113267205632 643 5742383 SGTC_2221 6807166 181.081 µM 1.24256418861844 0.10039552287314 no 362 0.107014236627721 497 674925 SGTC_497 capsazepine 133 µM 1.24206246227889 0.100487437218564 no 363 0.107106758502801 567 2733484 A calcium channel blocker. SGTC_2682 pyrogallin 40.03 µM 1.24108514041479 0.100666655094185 no 364 0.10728714915249 645 822798 An ATP competetive kinase inhibitor. SGTC_442 cape 100 µM 1.23870662566629 0.10110379271143 no 365 0.107727082050023 532 5281787 SGTC_2977 9011197 71.43 µM 1.23854569892257 0.101133418678888 no 366 0.10775689411975 511 2704722 SGTC_2010 4012422 159 µM 1.23450235966853 0.101879858866143 no 367 0.108507883992918 615 952393 SGTC_611 3453-1652 23.7 µM 1.23375936316715 0.102017458335239 no 368 0.108646293027968 634 1560575 SGTC_426 0988-0037 14.6 µM 1.23372307733755 0.102024181762503 no 369 0.10865305578102 652 5383008 SGTC_804 1595-0054 20.9 µM 1.23325472410777 0.102110992207187 no 370 0.10874037205092 566 761523 Stimulates phospholipase C. SGTC_1633 st005664 67.9 µM 1.22916342473557 0.102871610800276 no 371 0.10950526954304 610 2063822 SGTC_2782 7736369 71.43 µM 1.22767311508189 0.103149696500143 no 372 0.109784851363823 631 2950836 YOL077C BRX1 SGTC_871 0574-0004 149 µM 1.22521439684604 0.103609675884883 no 373 0.110247225740154 641 9551173 SGTC_2795 7780010 54.55 µM 1.22450366718722 0.10374291677001 no 374 0.110381141880263 557 953673 SGTC_842 0271-0008 11.1 µM 1.22434909696942 0.103771910584324 no 375 0.110410281535284 638 1221709 SGTC_705 1124-0212 310 µM 1.22380926611026 0.103873216538705 no 376 0.110512093987622 621 9554485 SGTC_808 0711-0032 135 µM 1.22369967639478 0.103893791163771 no 377 0.11053277089511 590 4252555 SGTC_1246 0422-0085 105 µM 1.22049661156262 0.104496448167037 no 378 0.111138336636904 655 264295 SGTC_2964 9083345 53.42 µM 1.22044583307792 0.104506022496011 no 379 0.111147955818616 554 17741579 SGTC_3018 9082602 49.47 µM 1.21839280256139 0.104893655709451 no 380 0.111537369449533 646 17332089 SGTC_2696 st077691 74.316 µM 1.21820652878571 0.10492887754947 no 381 0.111572749635097 537 757133 SGTC_3073 9114972 49.47 µM 1.21462315282179 0.105608112651894 no 382 0.112254927097426 548 41905075 SGTC_3060 1327-0027 12.5 µM 1.21449578094206 0.105632314589316 no 383 0.112279229983513 570 16000455 YPR107C YTH1 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.2066706165607 0.107126874465109 no 384 0.113779509683444 862 16725076 SGTC_688 0527-0193 473 µM 1.1952880509116 0.109328009048755 no 385 0.115987253354124 584 4007154 SGTC_1916 st067606 49.2 µM 1.19251309184147 0.109869515710293 no 386 0.116530060228583 670 19590279 SGTC_852 0418-0143 439 µM 1.19181112052213 0.110006803223491 no 387 0.116667657181296 697 5369229 SGTC_476 mead acid 10 µM 1.18889463151023 0.110578511349856 no 388 0.117240566477851 550 5312531 An omega 9 fatty acid. SGTC_950 1165-0508 94.1 µM 1.18709259669518 0.110932820045768 no 389 0.117595549110827 587 6148369 SGTC_2764 methyldopa 94.69 µM 1.18644366022077 0.111060610216166 no 390 0.117723569175674 665 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2151 5563267 85.4165 µM 1.18567959601156 0.111211206723205 no 391 0.117874427660824 647 5310824 SGTC_2024 5144227 134 µM 1.18561816926184 0.111223320238052 no 392 0.117886561828327 677 3475211 SGTC_1044 1222-0021 1.78 µM 1.1845223591807 0.111439575597616 no 393 0.118103175378326 634 4306703 SGTC_2448 5185112 27.17 µM 1.18435968290869 0.111471704985446 no 394 0.118135356286593 573 5718189 SGTC_717 1532-0246 73.2 µM 1.18343164868108 0.111655123232361 no 395 0.118319060260168 637 9561992 SGTC_3262 9137218 49.47 µM 1.18177542278875 0.111982998816292 no 396 0.118647411104817 470 17650664 SGTC_203 k066-0004 30.888 µM 1.17989263077623 0.112356562107513 no 397 0.11902146058657 751 6795412 SGTC_244 nsc-207895 1.295 µM 1.17957284561721 0.112420098788498 no 398 0.11908507411723 517 42640 SGTC_2281 7943571 200 µM 1.17562881751342 0.113205831382847 no 399 0.119871617357919 683 1244024 SGTC_888 0916-0002 6.97 µM 1.17308517838193 0.113714651048369 no 400 0.120380824785455 669 2802138 YIL048W NEO1 SGTC_104 0074-0074 590.992 µM 1.17063775722918 0.114205760471015 no 401 0.12087220690298 500 3943124 SGTC_2698 st077697 67.5 µM 1.16875899249566 0.114583784504518 no 402 0.121250373246142 605 3154499 SGTC_2235 salicylic acid 500 µM 1.16718220454402 0.114901734796576 no 403 0.121568397916594 624 338 A COX inhibitor and kinase inhibitor. SGTC_1006 4099-6547 255 µM 1.16536087146174 0.115269776707548 no 404 0.121936474432842 653 3146833 SGTC_1114 scopoletin 1.73284 µM 1.16448414953948 0.115447236839047 no 405 0.122113931572707 641 5280460 A coumarin with genotoxic properties. SGTC_2458 5808907 16.39 µM 1.16017889773796 0.116321494257104 no 406 0.122987988369202 707 2731747 SGTC_680 0417-1641 114 µM 1.15990182711562 0.116377918786927 no 407 0.123044389379682 615 2835990 SGTC_1429 4049-0205 9.46 µM 1.15885944781156 0.116590369867261 no 408 0.123256740455418 713 22774478 SGTC_1392 3455-1037 33.9 µM 1.15860028883877 0.116643232655112 no 409 0.123309575552208 656 981132 SGTC_926 2268-1401 59.4 µM 1.15729385676771 0.116909975141019 no 410 0.123576161279392 662 2931578 SGTC_751 0833-0568 350 µM 1.15697851661057 0.116974424853619 no 411 0.123640568858299 654 6954252 SGTC_2246 7293507 91.5585 µM 1.1561705092408 0.117139681563018 no 412 0.123805709973739 676 887656 SGTC_2584 androsterone 48.74 µM 1.15553524267596 0.117269724765147 no 413 0.123935654577534 810 2754130 A steroid. SGTC_2827 7993847 71.43 µM 1.15481453367024 0.117417382363916 no 414 0.124083192083405 598 2985692 SGTC_2344 7990960 76.95 µM 1.15280381287236 0.117830031192811 no 415 0.124495459521816 626 140813 SGTC_2880 9042983 58.44 µM 1.14959518055601 0.118490644013621 no 416 0.125155322049121 658 6464714 SGTC_1260 0700-1617 7.75 µM 1.14847514576893 0.118721858803016 no 417 0.12538623379941 685 2853078 SGTC_3058 9093861 49.47 µM 1.13895419202466 0.120700196274573 no 418 0.127361130385484 655 17217477 SGTC_873 0591-4978 488 µM 1.13503788939517 0.121520655038508 no 419 0.128179721685822 741 3305145 SGTC_2167 5876490 200 µM 1.13483154093818 0.121563993148417 no 420 0.128222954048117 678 686534 SGTC_491 tetrandrine 80.3 µM 1.13482078413628 0.121566252631891 no 421 0.128225207998824 629 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1184 1269-1718 139 µM 1.13346055900905 0.121852207999098 no 422 0.128510447578383 681 5403821 SGTC_2894 9048625 32.47 µM 1.13341822654076 0.12186111498123 no 423 0.128519331769352 679 4092861 SGTC_2583 asiatic acid 100 µM 1.13098212551556 0.1223744545874 no 424 0.129031307394577 652 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1949 st076024 69.1 µM 1.12965154089799 0.122655477768397 no 425 0.129311541992552 647 2921930 SGTC_617 3770-0098 35 µM 1.12615073095056 0.123397020021406 no 426 0.13005086192528 641 5962639 SGTC_3330 9141424 71.43 µM 1.12253145723462 0.124166951275776 no 427 0.130818270089657 728 27261020 SGTC_2940 9060638 45.86 µM 1.12105244448773 0.12448254822722 no 428 0.131132769745266 682 4027022 SGTC_887 0885-0007 9.62 µM 1.11836391445624 0.125057671691556 no 429 0.131705799822513 716 5719458 SGTC_399 oxolinic acid 75 µM 1.11732408370339 0.125280606556944 no 430 0.131927890802159 673 4628 A DNA gyrase inhibitor. SGTC_2279 7948423 32.93 µM 1.11517285394787 0.125742700598452 no 431 0.132388178226127 628 1247112 SGTC_380 3970-0968 6 µM 1.11244419865534 0.126330537009515 no 432 0.132973604950556 666 2891601 SGTC_1262 0737-0114 49.6 µM 1.11244388909851 0.126330603806049 no 433 0.132973671466209 776 765919 SGTC_1938 st074717 56.4 µM 1.10743629869342 0.127414369355578 no 434 0.134052669695785 630 17250979 SGTC_883 0850-0245 24.6 µM 1.10637275067329 0.12764537729656 no 435 0.134282607406798 732 6823229 YPR165W RHO1 SGTC_323 4013-0906 34.3 µM 1.10613746157849 0.127696522570009 no 436 0.134333513174736 685 2910086 SGTC_273 hydroxyurea 18.1 mM 1.10304970227885 0.128369035422248 no 437 0.135002790843657 779 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_362 0310-0100 9.03 µM 1.10253235373708 0.128481953814117 no 438 0.135115150422378 669 790235 SGTC_1170 0310-0127 64.8 µM 1.10187995270229 0.128624447524591 no 439 0.135256932572482 725 774975 SGTC_2648 atorvastatin 78.68 µM 1.09767452305898 0.129545605241083 no 440 0.136173319216693 687 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_1940 st075990 51.1 µM 1.0940665255377 0.130339535631051 no 441 0.136962901197297 780 1084979 SGTC_1817 st052116 64.4 µM 1.09251542276938 0.130681884159886 no 442 0.13730330764214 698 4361398 SGTC_1342 1486-1464 234 µM 1.09111519076233 0.1309914670079 no 443 0.137611099685683 739 3253938 SGTC_3127 9126946 49.47 µM 1.08808120183844 0.131664001131167 no 444 0.138279630796133 629 27243249 SGTC_1798 st045719 60.953 µM 1.08731302586354 0.131834657478695 no 445 0.138449246922991 674 3980186 SGTC_774 k060-0086 136 µM 1.0850550343918 0.132337171337262 no 446 0.138948640541341 810 5911235 SGTC_152 4469-0003 551.229 µM 1.08376461486606 0.132624945056706 no 447 0.139234589063843 724 697280 SGTC_390 dec-rvkr-cmk 16.7 µM 1.08235220542855 0.132940417294063 no 448 0.139548028472387 741 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1413 3910-0535 34.4 µM 1.082308546951 0.132950176966995 no 449 0.139557724724444 748 2876951 SGTC_2636 apigenin dimethyl ether 100 µM 1.08230745850026 0.13295042029198 no 450 0.139557966467833 726 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1462 k081-0014 26.5 µM 1.07694700978164 0.134152477860755 no 451 0.140751969877276 557 3270634 SGTC_2272 7805186 180 µM 1.07498551095314 0.134594195608643 no 452 0.141190607654542 736 2956062 YPR165W RHO1 SGTC_2208 7283366 200 µM 1.07325657023877 0.134984369562615 no 453 0.14157800762594 753 898663 SGTC_894 0960-0238 55.9 µM 1.07260872283145 0.13513077036107 no 454 0.141723354689395 754 6741907 YDL195W SEC31 SGTC_514 4466-0038 2.65 nM 1.07034365927071 0.135643485860923 no 455 0.14223232464277 794 5722064 SGTC_1661 st013063 9.66 µM 1.07011431062623 0.135695474987889 no 456 0.142283929187138 789 721395 SGTC_798 1287-0182 476 µM 1.06536945169894 0.136774110097343 no 457 0.143354387553589 803 1649755 SGTC_2063 5246145 200 µM 1.06492715570754 0.13687495378938 no 458 0.143454447586523 756 711240 SGTC_455 paf C-16 10 µM 1.06245124431294 0.137440401104365 no 459 0.144015440341364 711 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_248 streptozotocin 5.23457 mM 1.06143016542154 0.137674058405387 no 460 0.144247227035279 777 5300 DNA alkylating agent. SGTC_1227 3909-8010 46.6 µM 1.05603449339606 0.13891327028019 no 461 0.145476228099187 740 15982272 SGTC_1492 4158-0558 28.5 µM 1.05413979112934 0.139350218516565 no 462 0.145909460382326 736 3967268 SGTC_2102 5377816 72.7585 µM 1.05287630389704 0.139642117753039 no 463 0.146198843851857 786 1379702 SGTC_1643 st009866 20.2 µM 1.05186679315703 0.139875640249005 no 464 0.146430334531019 744 3156273 YOR207C RET1 SGTC_3266 9136860 49.47 µM 1.05051170087467 0.140189520568322 no 465 0.146741457083621 743 4871271 YPR165W RHO1 SGTC_923 1900-2434 73.3 µM 1.04919666453945 0.14049457983076 no 466 0.147043806739105 722 5910570 SGTC_2876 9059903 25.97 µM 1.04687654938504 0.141033893327136 no 467 0.147578259433982 810 6916095 SGTC_2993 9054257 71.4286 µM 1.04636251269912 0.141153571506607 no 468 0.147696846791445 751 6470217 YGL055W OLE1 SGTC_236 1509-0011 5.31 µM 1.04523773160257 0.141415683516506 no 469 0.147956554354066 980 3107280 SGTC_838 0109-0203 71.4 µM 1.04357403445162 0.141803985628003 no 470 0.148341255680299 774 759422 SGTC_1284 0929-0043 16 µM 1.04202029379276 0.142167275686639 no 471 0.148701135140875 768 1239883 SGTC_2322 7413319 38.22 µM 1.03693201882479 0.143361403916506 no 472 0.149883770236825 854 1840400 SGTC_954 1189-0853 2.85 µM 1.036103633664 0.143556450477563 no 473 0.15007689860408 791 2828194 SGTC_63 0099-0242 26.702 µM 1.03544004470806 0.143712824276977 no 474 0.150231726280319 816 3898502 YLR359W ADE13 SGTC_3192 9110362 49.47 µM 1.03312105542427 0.144260193260196 no 475 0.150773625515114 793 16649480 SGTC_2220 6782180 200 µM 1.02907378093211 0.14521886556753 no 476 0.151722502852518 674 833803 SGTC_1834 st055981 52.8 µM 1.02884302813341 0.145273652535727 no 477 0.151776721818323 796 471719 YDL150W RPC53 SGTC_649 1123-0311 367 µM 1.0254843603495 0.146072665594905 no 478 0.15256735059343 820 693629 YIL048W NEO1 SGTC_1494 4358-1428 177 µM 1.01583392142658 0.148384866745524 no 479 0.154854239839794 828 1564571 SGTC_2785 7756463 72.73 µM 1.01305291396312 0.149055702540342 no 480 0.155517443611065 771 2201551 SGTC_1746 st038117 42 µM 1.01172014589334 0.149377910387676 no 481 0.155835940128134 765 2898218 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.01106426178438 0.149536646454489 no 482 0.155992836962338 778 688662 SGTC_2343 7990716 14.84 µM 1.009888986334 0.149821366309174 no 483 0.156274239957689 804 6456862 SGTC_2875 9039966 71.43 µM 1.00753589519716 0.150392507481669 no 484 0.156838658570182 779 6463691 SGTC_668 1682-0499 62.6 µM 1.00745848534797 0.150411320977475 no 485 0.15685724906085 831 682214 SGTC_2942 9052777 62.25 µM 1.00424958905199 0.151192582860451 no 486 0.157629162658586 860 6469503 SGTC_344 k064-0035 6.43 µM 1.00420982748884 0.151202280410034 no 487 0.15763874309848 771 5088750 SGTC_562 3772-2733 112 µM 1.00262008883669 0.151590344846329 no 488 0.15802209968463 880 2876874 YIL048W NEO1 SGTC_2989 9073649 71.4286 µM 0.998335102507757 0.152639629536026 no 489 0.159058445741099 873 21367202 SGTC_2752 diclazuril 33.15 µM 0.997858685973474 0.152756588810371 no 490 0.159173943982654 964 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2844 9010103 25.97 µM 0.997605839866772 0.152818686144984 no 491 0.159235264081275 766 2480525 SGTC_140 0062-0056 502.533 µM 0.995374454140557 0.153367425437767 no 492 0.159777089168554 868 3758964 SGTC_2766 oltipraz 83.91 µM 0.995092096507431 0.153436955359589 no 493 0.159845737120646 778 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_82 0054-0107 293.755 µM 0.99471771851327 0.153529177275168 no 494 0.159936787187993 815 3104697 SGTC_1250 0485-0349 40.2 µM 0.993437191994229 0.153844891564712 no 495 0.160248472195904 768 6842794 YDL195W SEC31 SGTC_2514 salinomycin 42.74 µM 0.991700434885327 0.154273775812355 no 496 0.160671839427838 893 23682228 A polyether potassium ionophore. SGTC_1748 st037455 53.6035 µM 0.9910044582746 0.154445865762524 no 497 0.160841701655723 786 580690 SGTC_555 4296-0685 37 µM 0.990657380712166 0.154531732948806 no 498 0.160926454286638 850 2908540 YHR072W ERG7 SGTC_1490 4089-0339 670 nM 0.990408123445045 0.154593418802613 no 499 0.160987338228812 789 742542 SGTC_1325 1431-0015 227 µM 0.988226859817118 0.155133929253038 no 500 0.161520778200586 763 1103340 SGTC_1375 2910-0797 186 µM 0.986327306197799 0.155605647977387 no 501 0.161986262163137 800 742508 SGTC_1841 st054148 70 µM 0.986060620984677 0.155671949935939 no 502 0.162051683024297 757 675442 SGTC_2075 5212009 200 µM 0.98548058182184 0.155816220725661 no 503 0.162194032517073 727 780898 SGTC_376 3970-0862 59.1 µM 0.985157997593655 0.15589649392736 no 504 0.162273234290485 840 3135186 SGTC_937 3122-0005 46.7 µM 0.983169330609678 0.156391964078415 no 505 0.162762053271377 862 759535 SGTC_1216 1165-0504 9.65 µM 0.982460999148413 0.156568692852065 no 506 0.162936393859968 841 6304004 SGTC_2117 5521686 200 µM 0.982174613159087 0.156640183498012 no 507 0.163006916080462 795 803312 SGTC_1948 st076329 66.6 µM 0.981060626738096 0.156918472686903 no 508 0.163281422629853 776 24208413 SGTC_2946 9065502 71.43 µM 0.979634122653887 0.157275307776962 no 509 0.16363337751835 660 16489101 SGTC_893 0958-0369 48.9 µM 0.979611201587729 0.157281045754339 no 510 0.163639036746955 838 6819948 SGTC_3232 9132874 49.47 µM 0.979193996252285 0.157385511490945 no 511 0.163742067266732 798 3784940 SGTC_2372 9071633 200 µM 0.978410120857257 0.157581912551685 no 512 0.163935762275767 898 21321366 SGTC_385 1494-0393 12.4 µM 0.977045941620375 0.157924093366959 no 513 0.164273204276867 850 3090647 SGTC_1176 0848-0131 83.3 µM 0.976149581503324 0.158149195240486 no 514 0.164495172031048 868 6769040 SGTC_3053 9095903 49.47 µM 0.975020011517784 0.158433162589286 no 515 0.164775166797611 861 17174018 SGTC_2193 5925765 200 µM 0.974794644269954 0.158489858607236 no 516 0.164831067145406 799 877370 SGTC_1832 st054113 55 µM 0.973624612495806 0.158784419327068 no 517 0.165121480552246 796 1251267 SGTC_2098 5376439 882.5 nM 0.969843831994723 0.159738699477821 no 518 0.166062170396832 887 2844116 SGTC_1363 1636-0063 10.4 µM 0.968338588972718 0.160119669468401 no 519 0.166437649273031 867 6072185 SGTC_1653 st012112 65 µM 0.968277512628519 0.160135140136796 no 520 0.16645289616767 790 720429 SGTC_3322 9139058 2.11 µM 0.967138066527592 0.160423941574473 no 521 0.166737509015267 845 4908926 YPR165W RHO1 SGTC_2036 5160441 105 µM 0.96702266030156 0.160453211144386 no 522 0.166766352887126 888 134534 YIL048W NEO1 SGTC_1651 st011928 86.1 µM 0.966885672746124 0.160487958745064 no 523 0.166800594832727 828 720198 SGTC_587 k089-0003 57 µM 0.966605489473695 0.160559043988036 no 524 0.166870644665864 722 9659696 SGTC_1203 3992-3522 103 µM 0.96542480815146 0.160858820326792 no 525 0.167166040353501 875 5322312 SGTC_2625 euphol 100 µM 0.963032516316346 0.161467345479432 no 526 0.167765602783472 862 6708538 A triterpene alcohol. SGTC_662 k832-1615 104 µM 0.961586661804206 0.161835853014018 no 527 0.168128637102075 818 5878478 SGTC_3081 9117243 49.47 µM 0.961457445242889 0.161868813325743 no 528 0.16816110620324 844 45595589 SGTC_1851 st056236 18.9 µM 0.960848821934707 0.162024118598753 no 529 0.168314093260888 883 5393171 SGTC_2854 9024559 71.43 µM 0.96002953572296 0.162233332923033 no 530 0.168520175074666 804 3163529 SGTC_1922 5578187 25 µM 0.959801374100394 0.162291627961634 no 531 0.168577595315852 800 1350412 SGTC_1209 2323-2347 50.3 µM 0.958796700870014 0.162548483046726 no 532 0.168830585772056 852 5412760 SGTC_646 4092-0839 27.3 µM 0.958698462505968 0.162573612887522 no 533 0.168855336621657 884 877796 SGTC_2858 9025781 8.96 µM 0.957055981683555 0.162994141693942 no 534 0.169269499840962 940 4894980 YPL153C RAD53 SGTC_2206 7254556 146.969 µM 0.955929134718621 0.163283059999857 no 535 0.169554019163957 839 4398905 SGTC_1749 st037932 54.2 µM 0.954936159011613 0.163537929958343 no 536 0.169804991292517 802 594497 SGTC_2973 9094665 17.96 µM 0.954764855634207 0.163581925008122 no 537 0.16984831187389 902 25237061 YIL048W NEO1 SGTC_1287 0971-0001 34.6 µM 0.95362542165716 0.163874756083064 no 538 0.170136641450007 894 4665869 SGTC_3024 9090631 49.47 µM 0.952211766277792 0.164238533762615 no 539 0.170494797445157 814 25236383 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.951468212035823 0.164430083486085 no 540 0.170683373896162 795 77254 SGTC_1879 gemcitabine 100 µM 0.951116270542867 0.164520798893179 no 541 0.17077267804539 851 60750 A nucleoside analog which inhibits DNA replication. SGTC_2093 5331342 194.4 µM 0.949904958489035 0.164833271023272 no 542 0.171080273555151 871 33839 SGTC_2976 9009005 19.48 µM 0.949399973426925 0.16496365128923 no 543 0.171208611940546 876 2993148 SGTC_2720 fluspirilene 36.88 µM 0.948006300123835 0.165323825124048 no 544 0.171563123460704 779 3396 An atypical antipsychotic. SGTC_2912 7964298 10.93 µM 0.946728637857472 0.165654464390003 no 545 0.171888536814443 899 2975850 SGTC_80 0159-0065 512.242 µM 0.945976571168626 0.165849287424089 no 546 0.172080268100565 782 1548079 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.94586157783693 0.165879089519887 no 547 0.172109596436939 944 551469 SGTC_1333 1482-0047 286 µM 0.945766951309604 0.165903615875504 no 548 0.172133732738782 906 3811116 SGTC_1710 st031758 61.5 µM 0.945616464978492 0.165942625423568 no 549 0.172172121599044 852 5394341 SGTC_3131 9127911 49.47 µM 0.942914859323835 0.166643952610887 no 550 0.172862226885921 820 45595681 SGTC_702 1488-0190 94 µM 0.941821721049277 0.16692827020182 no 551 0.173141961250077 870 949357 SGTC_2490 carminic acid 95.39 µM 0.940826637464121 0.167187356330107 no 552 0.17339685393055 803 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3173 9105693 49.47 µM 0.94026488381326 0.167333732409065 no 553 0.173540853701864 904 17096658 SGTC_687 k029-0044 34.9 µM 0.940036749122049 0.167393201011626 no 554 0.173599355406515 931 5829338 SGTC_275 trichlorophene 5.69 µM 0.937448086449137 0.168068949869301 no 555 0.174264057824665 960 62616 SGTC_762 1165-0429 115 µM 0.935817505215545 0.168495499393551 no 556 0.174683578483637 871 5967793 SGTC_2957 9076800 11.52 µM 0.934763297693706 0.168771643419021 no 557 0.174955149043059 776 16459615 SGTC_463 ikarugamyin 104 µM 0.933831835139674 0.169015876914817 no 558 0.175195322519439 873 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2954 9074818 52.69 µM 0.93266019259444 0.169323408823947 no 559 0.175497722120873 843 16648742 SGTC_228 caffeine 993.056 µM 0.931536620094178 0.169618660497498 no 560 0.175788025456315 839 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2480 5767542 37.17 µM 0.928587423641025 0.170395218586616 no 561 0.176551470970642 906 2867358 SGTC_1861 st057647 17.4 µM 0.928575769683652 0.17039829172047 no 562 0.176554491932833 881 688668 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.928073663575316 0.170530730179578 no 563 0.176684679930816 858 5377381 SGTC_406 estrone 100 µM 0.927856979033265 0.170587904522189 no 564 0.176740881474283 901 5870 A steroid. SGTC_2013 4024628 200 µM 0.925714761193298 0.171153810028902 no 565 0.1772971173051 808 5230760 SGTC_1706 st031321 9.9705 µM 0.924990172677779 0.171345494567382 no 566 0.177485509663074 912 6103185 SGTC_2430 5571206 200 µM 0.924164797525665 0.171564008591224 no 567 0.177700260339891 980 1731771 SGTC_1735 st034310 56.75 µM 0.924068795346538 0.171589436252128 no 568 0.177725249357443 858 871153 SGTC_753 1322-0200 289 µM 0.92382272871146 0.171654621798391 no 569 0.177789309729647 902 5403907 SGTC_1072 oxiconazole 14.9 nM 0.919296215801486 0.172856562332571 no 570 0.178970328314557 893 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1068 loratadine 26.9 µM 0.918706941650601 0.173013427948545 no 571 0.179124438993772 858 3957 A H1 histamine antagonist. SGTC_2365 9042475 200 µM 0.918460238462089 0.17307912761105 no 572 0.179188983145242 866 6464479 SGTC_2749 bexarotene 57.39 µM 0.916689096372382 0.173551267941814 no 573 0.179652790683017 847 82146 An retinoic acid receptor inhibitor. SGTC_716 1683-5115 658 µM 0.916600302180026 0.173574959715206 no 574 0.179676062986478 972 723597 SGTC_33 0986-0033 35.816 µM 0.916573304703998 0.173582163500651 no 575 0.179683139201504 859 2848082 SGTC_2804 7954240 19.48 µM 0.91499655382328 0.174003220789279 no 576 0.180096719643924 907 828705 SGTC_1290 0986-0249 10.2 µM 0.912594605964884 0.174645886496392 no 577 0.180727896145741 876 53329 SGTC_227 fluconazole 33.516 µM 0.910759224732593 0.175137975970965 no 578 0.181211125569851 914 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_2807 7945238 51.95 µM 0.910596653582093 0.175181605761647 no 579 0.181253967190166 883 17148797 SGTC_1835 st008666 49.2 µM 0.910375694953251 0.175240916255762 no 580 0.181312205560049 794 690455 SGTC_71 0417-1750 47.813 µM 0.909146034744239 0.175571218572477 no 581 0.181636522808204 930 6811472 SGTC_645 0845-0943 5.41 µM 0.907582318446013 0.175991822062306 no 582 0.182049469793563 863 1885106 SGTC_755 1995-0008 37.3 µM 0.907101710091595 0.176121222658325 no 583 0.182176506923587 922 689533 SGTC_2568 diosmetin 100 µM 0.906813234692035 0.176198921653561 no 584 0.182252784983754 920 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2812 7970281 58.44 µM 0.906643452614772 0.176244661505327 no 585 0.182297687733671 909 2233435 SGTC_364 0083-0097 67.7 µM 0.906554356246005 0.176268667367026 no 586 0.182321254069813 884 5207356 SGTC_3109 9122853 49.47 µM 0.906236749064596 0.176354259339314 no 587 0.182405277892136 976 1234709 SGTC_2990 9074105 71.4286 µM 0.903729893139412 0.177030754661858 no 588 0.18306932204408 896 6502001 SGTC_832 4083-0019 164 µM 0.903269427252981 0.177155193111021 no 589 0.18319145917296 1058 1990758 SGTC_1546 5-methoxyflavanone 78.7 µM 0.90322285594258 0.177167781835088 no 590 0.183203814896071 940 147795 SGTC_1401 3807-4679 7.6 µM 0.902152805160886 0.177457183651534 no 591 0.183487850666972 874 3291456 SGTC_3329 9141233 27.5565 µM 0.901512545746421 0.177630488364286 no 592 0.183657933199666 894 4909101 YNL103W MET4 SGTC_1732 st034308 51.822 µM 0.90144457084267 0.177648894005634 no 593 0.183675996246605 850 830119 SGTC_2213 7173844 200 µM 0.90012421105884 0.178006648002281 no 594 0.184027076463514 933 892728 SGTC_1884 5633444 25 µM 0.899685131557908 0.178125718010628 no 595 0.184143919065712 913 5724239 SGTC_1215 3852-0577 11.2 µM 0.897406782590169 0.178744368813074 no 596 0.184750947315098 989 2884876 SGTC_1680 diphenhydramine 100 µM 0.897174349055491 0.178807558535015 no 597 0.184812945220362 884 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1726 st035556 14.5795 µM 0.895806275529777 0.179179769917467 no 598 0.185178118819676 953 5919439 SGTC_1032 k061-1018 98.7 µM 0.894838367931472 0.179443402419532 no 599 0.185436748454152 982 4005393 SGTC_2405 ticlatone 3.52 µM 0.893557217261663 0.179792728852349 no 600 0.185779422784123 954 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_264 promethazine 12.5 mM 0.892587256929666 0.180057488160699 no 601 0.186039122915445 1056 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_2351 9026858 72.31 µM 0.892439350685154 0.18009788198525 no 602 0.186078743550028 858 1409300 SGTC_1063 disulfiram 1.84 µM 0.891751723113343 0.180285750695993 no 603 0.186263011622072 916 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1906 st060206 94.7 µM 0.891084654130298 0.180468120011978 no 604 0.186441878482556 971 5133468 SGTC_2497 7-hydroxyflavone 100 µM 0.890185883309969 0.180714016984542 no 605 0.186683041697219 845 5281894 SGTC_1887 st057648 70.8 µM 0.883435748480474 0.18256751081026 no 606 0.188500441553438 932 688672 SGTC_235 0330-0087 5 mM 0.881981296902008 0.182968432443302 no 607 0.188893460753522 967 46494818 YHR062C RPP1 SGTC_2307 7538926 6.34 µM 0.881461849317947 0.183111751946582 no 608 0.189033947184381 927 96582 SGTC_1050 3232-1156 69.3 µM 0.881172067520972 0.183191735351043 no 609 0.189112347651929 878 700529 SGTC_1691 st019933 84.6 µM 0.880947605397718 0.183253704681593 no 610 0.189173089642164 932 6176082 SGTC_3022 9087993 49.47 µM 0.879705478036753 0.183596866538577 no 611 0.189509440503265 954 17173644 SGTC_615 k087-0205 167 µM 0.877574759449282 0.184186450938153 no 612 0.190087265911608 886 9642773 SGTC_2897 9048598 12.99 µM 0.87667358437246 0.18443616644038 no 613 0.190331979281084 911 6467404 SGTC_1076 itraconazole 331 nM 0.875339994071203 0.184806090369794 no 614 0.19069446952514 1002 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_3261 9137475 49.47 µM 0.873798101323241 0.185234369621558 no 615 0.19111410731402 770 17027690 SGTC_353 1988-1175 58.3 µM 0.873788750300621 0.185236968859436 no 616 0.191116653991854 885 2788357 SGTC_2743 auranofin 4.32 µM 0.872811335998813 0.185508778730016 no 617 0.191382959876904 925 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2919 7978188 46.38 µM 0.872609169894959 0.185565030132255 no 618 0.191438070336606 962 2980291 SGTC_3100 9120536 49.47 µM 0.872071972283883 0.185714553295359 no 619 0.191584557594169 833 16421196 SGTC_795 0685-0265 78 µM 0.871243067768237 0.185945416524765 no 620 0.191810724446641 986 302754 SGTC_722 3534-0461 190 µM 0.869546625512852 0.186418457437069 no 621 0.192274108588135 971 658262 SGTC_2966 9084041 48.03 µM 0.869014136817261 0.186567091717226 no 622 0.192419699241793 879 17741380 SGTC_351 caspofungin 25 nM 0.868748246765726 0.186641337424897 no 623 0.192492422924188 1052 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_601 0986-0029 62.9 µM 0.867748851357735 0.186920566789734 no 624 0.1927659181564 958 24747981 SGTC_2868 9035608 32.47 µM 0.867277971077059 0.18705221947373 no 625 0.192894861819103 947 6462614 SGTC_2624 nerol 100 µM 0.866960087868001 0.187141128368379 no 626 0.192981939256547 934 637566 A natural product oil. SGTC_1568 digitonin 820 nM 0.86692678565272 0.187150444191887 no 627 0.192991063088857 987 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_134 0269-0018 6.916 µM 0.866088792538694 0.187384955309873 no 628 0.19322073537925 882 4378915 SGTC_148 3253-0744 288.01 µM 0.86563494942479 0.187512038420465 no 629 0.1933451916791 959 6893655 SGTC_400 oxethazaine 37.5 µM 0.864547244086449 0.187816829509491 no 630 0.193643669525467 913 4621 A local anesthetic. SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.862343291320949 0.188435346992877 no 631 0.194249318330795 956 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1366 1683-0113 21.9 µM 0.861692686035717 0.18861817280441 no 632 0.194428325721438 952 708623 SGTC_1120 ficusin 1.78878 µM 0.861636447019336 0.188633981596479 no 633 0.194443804025599 954 6199 A DNA cross-linker. SGTC_743 1275-0778 158 µM 0.861168706499085 0.188765495141118 no 634 0.194572566311964 988 2849257 YMR203W TOM40 SGTC_2493 resveratrol 26.09 µM 0.860006756852876 0.189092442371109 no 635 0.194892658945273 899 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_931 2812-0076 566 µM 0.857883635735461 0.189690742398621 no 636 0.195478360579105 975 3450959 SGTC_2926 9010726 65.15 µM 0.856971851298032 0.189948042189199 no 637 0.195730220708067 945 2994293 SGTC_3355 9151058 44.0485 µM 0.856521146331067 0.190075307475178 no 638 0.195854790624134 982 17015728 SGTC_2529 gangaleoidin 93.61 µM 0.855336415165595 0.190410089125622 no 639 0.196182466709411 969 4565183 SGTC_997 3996-0078 137 µM 0.855016097238774 0.190500666803296 no 640 0.196271118149315 1000 735687 SGTC_2067 5224629 34.075 µM 0.854659434800061 0.190601552897976 no 641 0.196369856896714 952 2835000 SGTC_3267 9137951 49.47 µM 0.853889889859609 0.190819339279711 no 642 0.196583000943792 969 16643986 SGTC_2284 7945075 39.21 µM 0.853737186091794 0.190862573618998 no 643 0.196625312598549 1049 1245402 SGTC_901 1112-0062 60.1 µM 0.852440016149575 0.191230077894254 no 644 0.196984959086081 954 1908457 SGTC_818 4072-2707 53.5 µM 0.851302185632622 0.191552796220201 no 645 0.197300755560788 974 882871 SGTC_465 cgp-37157 41 µM 0.851181931477638 0.1915869229087 no 646 0.19733414909874 874 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2949 9072542 2.23 µM 0.850194987055268 0.191867146602405 no 647 0.197608344160245 985 16457352 SGTC_2175 5807670 165.306 µM 0.847721262868326 0.19257061433872 no 648 0.198296610929434 965 241186 SGTC_3101 9120531 49.47 µM 0.847406170732413 0.192660332029744 no 649 0.198384383095013 984 24824904 SGTC_3092 9117248 49.47 µM 0.847275554498094 0.192697530502849 no 650 0.198420774466978 1034 17141857 SGTC_1856 st057054 55.7 µM 0.845709287950692 0.193143932638371 no 651 0.198857470247984 1009 1266018 SGTC_1977 st070720 65.3 µM 0.844001792749304 0.193631304998541 no 652 0.199334201906163 921 682188 SGTC_1867 st057372 64 µM 0.842960515729504 0.193928885708945 no 653 0.199625263342847 1011 688837 SGTC_3352 9151559 45.5865 µM 0.840629140532297 0.194596166168392 no 654 0.200277864214824 950 17159339 SGTC_2763 lisinopril 49.32 µM 0.84038331172421 0.194666608020488 no 655 0.200346751491654 954 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_2543 pimpinellin 60.67 µM 0.83707330644241 0.19561659485617 no 656 0.201275681882864 931 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_3170 9103054 49.47 µM 0.836464479147747 0.195791637091356 no 657 0.201446825832186 936 16432970 SGTC_109 0132-0036 33.701 µM 0.836182546038796 0.195872727085015 no 658 0.201526107965434 875 67274 A color developer. SGTC_2317 5986382 200 µM 0.832895854928516 0.196819552612821 no 659 0.20245173380098 1020 877883 SGTC_2594 a-mangostin 100 µM 0.832703426071535 0.196875073004226 no 660 0.202506005905011 1003 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_2948 9070189 9.45 µM 0.831773309990318 0.197143567709635 no 661 0.202768455882513 903 6473636 YDL196W YDL196W SGTC_2927 9011802 47.9 µM 0.828536602251521 0.198079627198975 no 662 0.20368333749139 967 43912568 SGTC_2429 5902844 64.44 µM 0.827428959739716 0.198400573995816 no 663 0.203996985975158 1030 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1921 5740136 50 µM 0.827146979828369 0.198482329635543 no 664 0.20407687948375 1025 1774243 SGTC_1384 3089-0840 101 µM 0.825554660566914 0.198944378874015 no 665 0.204528381790391 960 1069836 SGTC_1214 0358-0031 63.7 µM 0.824419553668778 0.199274152505332 no 666 0.204850604095236 962 4301366 SGTC_3342 9147791 14.508 µM 0.82306109954158 0.199669245875226 no 667 0.205236624426711 1012 1838168 SGTC_2182 6325192 200 µM 0.822894544398434 0.199717719258341 no 668 0.205283982706285 966 736248 SGTC_3137 9097352 49.47 µM 0.822563293855658 0.199814145813699 no 669 0.205378189758589 1068 44120435 SGTC_1996 st072960 66.8 µM 0.820311918307324 0.200470259621635 no 670 0.20601915689796 1033 1719405 SGTC_1772 st048439 82.2 µM 0.818831581991307 0.200902375292628 no 671 0.206441254719383 982 2927068 YDL195W SEC31 SGTC_2305 7443522 69.23 µM 0.817429837187556 0.201312064526525 no 672 0.206841415148208 1028 5415886 SGTC_2251 lansoprazole 556 µM 0.814713268839344 0.202107462840875 no 673 0.20761822818563 843 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_3255 9139072 49.47 µM 0.814685711835027 0.202115541023747 no 674 0.20762611703729 1062 17646060 SGTC_1793 st048256 72.231 µM 0.814497440897228 0.202170736773145 no 675 0.207680018835106 987 672022 SGTC_2588 indole-3-carbinol 100 µM 0.812959698512346 0.202621897186827 no 676 0.208120582505839 1028 3712 Induces cell cycle arrest. SGTC_81 0411-0046 9.971 µM 0.81293495056552 0.202629162938616 no 677 0.208127677307246 935 12925265 SGTC_2557 derrustone 83.84 µM 0.812651976832825 0.202712252289765 no 678 0.208208811049692 1058 629853 An antioxidant. SGTC_2077 5212015 200 µM 0.811961448959958 0.202915096880028 no 679 0.208406876335049 972 780900 SGTC_2537 larixol 68.93 µM 0.810768961644609 0.203265678856854 no 680 0.208749181037773 1047 6708759 SGTC_1925 st057770 10.1 µM 0.810494431453971 0.203346439754244 no 681 0.208828032103642 955 5989122 SGTC_132 0417-1715 25.805 µM 0.809118948720691 0.203751365490871 no 682 0.209223364938204 1059 6769098 SGTC_327 1273-0057 3.96 µM 0.806981366461776 0.204381597368043 no 683 0.209838609318925 998 3108138 SGTC_2003 4023581 200 µM 0.806259543076286 0.20459467724536 no 684 0.210046606321878 1008 16641307 SGTC_2702 st077768 96.8 µM 0.806191920694064 0.204614645918249 no 685 0.210066098251757 934 6484119 SGTC_3011 9081274 71.4286 µM 0.803906748847048 0.205290131316761 no 686 0.2107254160633 1041 6625322 SGTC_1318 1280-3875 124 µM 0.80369585046179 0.205352538527141 no 687 0.210786325592324 1023 373245 SGTC_2683 piperine 63.03 µM 0.802907713437616 0.205585856880141 no 688 0.211014038701707 1003 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_2271 7849410 118.62 µM 0.800046617735079 0.206434170978769 no 689 0.211841894071162 1054 972430 SGTC_849 0386-0493 241 µM 0.799634182414296 0.206556628743699 no 690 0.211961388353875 1009 726119 SGTC_1089 terbinafine 2.25 µM 0.798785993530874 0.206808602976258 no 691 0.212207256751672 1030 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2657 nystatin 74.44 µM 0.795692139056519 0.207729245500356 no 692 0.213105498511422 1076 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2742 clothiapine 36.27 µM 0.794440589713197 0.20810235745886 no 693 0.213469491177151 1007 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.79346112990845 0.208394629775188 no 694 0.21375460362838 1032 5282362 SGTC_70 0141-0289 43.283 µM 0.792921173005028 0.208555857219183 no 695 0.213911875297858 1142 352408 SGTC_3034 9090421 49.47 µM 0.790938688028776 0.209148444060721 no 696 0.214489885358 1015 17173761 SGTC_1907 st060210 83.7 µM 0.788294569202961 0.209940341529177 no 697 0.215262211781226 1109 688793 SGTC_966 1300-0360 30.2 µM 0.787394458512494 0.210210320699179 no 698 0.215525494836744 1018 70588 SGTC_394 menadione 8.33 µM 0.78464422021484 0.211036489393479 no 699 0.216331097772853 1049 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1755 st041960 45.185 µM 0.783263458901911 0.211451985283882 no 700 0.216736208296175 1046 2257073 SGTC_487 nimodipine 119 µM 0.78150042435135 0.211983209805783 no 701 0.217254113615885 987 4497 L-type voltage-gated calcium channels inhibitor SGTC_2834 9001755 58.44 µM 0.780288521820872 0.212348823564363 no 702 0.217610533717864 965 2989575 SGTC_3282 9108498 15.4605 µM 0.780040023360666 0.212423837516425 no 703 0.217683658693242 1022 16459645 SGTC_2114 5491910 81.25 µM 0.779909280841852 0.212463310829302 no 704 0.217722137634887 1069 2849228 SGTC_2391 6285546 200 µM 0.779543939014212 0.2125736362402 no 705 0.21782968249898 1077 846083 SGTC_1003 4049-0218 100 µM 0.779272607304271 0.212655594256486 no 706 0.217909573636883 1075 295161 SGTC_2295 7971645 200 µM 0.778697066510333 0.21282950224415 no 707 0.218079092275529 1042 2978226 YKL099C UTP11 SGTC_2545 solidagenone 89.61 µM 0.778530389737973 0.212879881542753 no 708 0.218128199110961 890 6708572 An anti ulcer agent SGTC_2386 9075165 157.42 µM 0.778452100046919 0.212903547588471 no 709 0.218151267265897 1056 16452277 SGTC_778 3456-2434 196 µM 0.776979567865055 0.213348962575369 no 710 0.218585412553631 1140 5539063 SGTC_2482 5981709 142.65 µM 0.775033557496081 0.21393842892727 no 711 0.219159915314201 1041 877755 SGTC_2913 7966556 36.57 µM 0.772223916097762 0.214791168458898 no 712 0.219990909469473 1033 2976516 SGTC_1822 st052468 42 µM 0.772131025791393 0.214819394791106 no 713 0.220018414027542 1085 2873678 SGTC_9 0092-0002 10.449 µM 0.769417019712733 0.215645043453234 no 714 0.220822894043082 1070 759368 SGTC_2472 5377652 49.4 µM 0.769060473392643 0.215753647721326 no 715 0.220928705785645 1069 1610903 SGTC_2200 6600604 21.907 µM 0.768619269882194 0.215888082511736 no 716 0.221059681292259 1072 2904777 SGTC_1865 st057639 52.2 µM 0.768257809677601 0.21599825566627 no 717 0.22116701733734 1107 688818 SGTC_1146 3579-1023 7 µM 0.767924861745413 0.216099767086667 no 718 0.221265913005044 1122 X1146 SGTC_2971 9092186 9.93 µM 0.766700962111283 0.216473155279137 no 719 0.221629665744706 1026 25236400 SGTC_2278 7948257 134.34 µM 0.766031611410059 0.216677519096742 no 720 0.221828746581284 1078 1247028 SGTC_1 0258-0098 57.368 µM 0.765901419219571 0.216717281880483 no 721 0.221867480701165 977 6790032 YDR047W HEM12 SGTC_2641 levomentholum 100 µM 0.763435226082885 0.217471293536321 no 722 0.222601939235836 1067 16666 SGTC_445 e6 berbamine 66 µM 0.760726733997104 0.218301127719898 no 723 0.223410151689516 1142 6610268 A calcium/calmodulin antagonist. SGTC_2692 st077426 47.7 µM 0.760707756362211 0.218306948560907 no 724 0.223415820488513 1109 25238571 SGTC_1877 wortmannin 25 µM 0.760394596033983 0.218403014351695 no 725 0.223509376256675 1123 312145 A covalent inhibitor of PI 3-kinase. SGTC_1751 st044839 27.194 µM 0.757903507768316 0.21916805308033 no 726 0.224254375098816 1118 5291326 SGTC_2439 5492030 7.2 µM 0.757682468292785 0.219236010905514 no 727 0.224320548439125 1066 5722370 SGTC_2770 toltrazuril 17.5 µM 0.757371279789226 0.219331705265302 no 728 0.224413728786274 1110 68591 Kills coccidiodes. SGTC_2126 5251174 33.877 µM 0.757063574487369 0.219426352095242 no 729 0.224505887741643 1156 790722 SGTC_314 1671-0008 2.74 µM 0.757021631408676 0.219439255150638 no 730 0.224518451522575 1062 3913060 SGTC_1810 st050138 53 µM 0.755404548251876 0.219937054816819 no 731 0.225003142528335 1107 3444541 SGTC_128 0906-2981 13.371 µM 0.754688467915483 0.220157698409731 no 732 0.22521796376078 1037 6740226 SGTC_1239 0337-0584 35.4 µM 0.751788112051291 0.221052673333572 no 733 0.226089246095707 1151 914301 YML130C ERO1 SGTC_3189 9110682 49.47 µM 0.750379273412469 0.221488154765184 no 734 0.226513155200843 1130 17122418 SGTC_561 1550-0330 72.9 µM 0.746379762759175 0.22272709908046 no 735 0.227719020306061 1087 6812934 SGTC_1515 3460-0031 42.1 µM 0.746277248865156 0.222758907047602 no 736 0.227749975991757 1059 2876596 SGTC_1358 1509-0022 2.48 µM 0.744050104671018 0.223450583135991 no 737 0.228423081665066 1133 3258434 SGTC_2296 7971656 126.45 µM 0.743399725885081 0.22365279917681 no 738 0.22861985510678 1136 666570 SGTC_2571 chrysanthemic acid 100 µM 0.743213472618161 0.223710728280588 no 739 0.228676223946214 1071 2743 An insecticide. SGTC_1788 fluconazole 20 µM 0.742987237528555 0.223781104135043 no 740 0.228744703627322 1071 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_343 4130-2827 29.8 µM 0.740997763380758 0.22440051949637 no 741 0.229347398222501 1136 1118244 SGTC_1642 st009582 77.7 µM 0.740727307315542 0.224484800055383 no 742 0.229429399307735 1117 6739311 SGTC_488 nitrendipine 139 µM 0.737562647597342 0.225472317278481 no 743 0.230390130298514 1137 4507 Dihydropyridine L-type calcium channel blocker. SGTC_3176 9106582 49.47 µM 0.737536817935288 0.225480387407539 no 744 0.230397980939527 1043 17018027 SGTC_1182 1222-0449 220 µM 0.736649718901238 0.225757648735791 no 745 0.230667695666936 1096 658318 SGTC_721 1187-1332 279 µM 0.736073162633109 0.225937953792224 no 746 0.230843087113367 1052 25730 SGTC_1610 st001799 48.1 µM 0.735817863421677 0.22601781890235 no 747 0.230920774258543 1034 621897 SGTC_594 1487-1584 10.8 µM 0.734169179339568 0.226533959956828 no 748 0.231422817572721 1140 5013332 SGTC_3114 9122766 49.47 µM 0.733830432306763 0.226640091275566 no 749 0.231526045271909 1066 17176985 SGTC_2253 7938677 135.83 µM 0.733504508877741 0.226742231373461 no 750 0.231625389409491 1135 2301972 SGTC_2833 9001315 45.46 µM 0.733281299763267 0.226812197144558 no 751 0.231693439084609 1106 2989378 SGTC_2703 st077852 53.4 µM 0.730787294951452 0.227594780575887 no 752 0.232454542540449 1108 6281836 SGTC_396 dithiazanine 1.25 µM 0.730502675912291 0.227684186556279 no 753 0.232541488954569 1111 10578 An antihelmenthic. SGTC_429 1112-0049 25.5 µM 0.729835901117293 0.227893714639341 no 754 0.232745248421279 1086 2836170 SGTC_666 0272-0154 136 µM 0.729834388257599 0.227894190165443 no 755 0.232745710848309 1159 6870312 SGTC_712 r015-0009 80.6 µM 0.728729286372779 0.228241697855755 no 756 0.233083637294511 1092 6813872 YLR060W FRS1 SGTC_639 0833-0042 114 µM 0.727162365587946 0.2287349382366 no 757 0.233563248863432 1143 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_783 0848-0141 92.7 µM 0.726018352194518 0.229095432106101 no 758 0.233913760023241 1124 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_1129 3453-1384 223 µM 0.7251173811707 0.229379564268123 no 759 0.234190011109025 1171 1084452 SGTC_1316 1272-0050 65.9 µM 0.724577190565827 0.229550014613121 no 760 0.234355728142525 1155 7340392 SGTC_35 0133-0054 64.071 µM 0.722343395341749 0.230255613540143 no 761 0.235041689490475 1124 99677 SGTC_1140 3229-1848 2.98 µM 0.721718223251347 0.230453306486269 no 762 0.23523386790266 1160 2849525 SGTC_2735 sertaconazole 140 nM 0.718472582927881 0.231481171719139 no 763 0.236232973520427 1193 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_920 mycophenolic acid 780.421 nM 0.716352410824248 0.232153989045166 no 764 0.236886886037057 1145 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1807 st050092 58.9 µM 0.715243807460703 0.232506227127881 no 765 0.237229202023111 1142 5008496 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.714395681112381 0.232775904011906 no 766 0.237491270921223 1121 689007 SGTC_324 1315-0088 19.6 µM 0.713948275545107 0.232918234583009 no 767 0.237629582111434 1110 6787421 SGTC_3093 9117344 49.47 µM 0.713571076348469 0.233038268352526 no 768 0.237746223998577 1115 24824913 SGTC_3317 9138495 8.753 µM 0.71315432464073 0.233170928606393 no 769 0.237875133279897 1176 17020139 SGTC_3299 9121982 43.1275 µM 0.712081100514184 0.233512749833075 no 770 0.238207278419304 1199 17594604 YPL160W CDC60 SGTC_2103 5378138 10 µM 0.710847085510091 0.233906126120397 no 771 0.238589499513173 1219 244142 SGTC_153 4077-0274 519.67 µM 0.709780273795226 0.234246497456121 no 772 0.238920201773556 1237 3121976 SGTC_2784 7567673 72.73 µM 0.709716957559251 0.234266707417229 no 773 0.238939837127357 1218 3471247 SGTC_1512 0259-0544 12.2 µM 0.708901348378755 0.234527128655349 no 774 0.239192849150662 1180 18476 SGTC_1470 k295-0292 231 µM 0.707294348510627 0.23504070653944 no 775 0.239691788435828 1195 5045612 SGTC_2205 7238770 200 µM 0.707148047149206 0.235087493536418 no 776 0.239737240087878 1193 279867 SGTC_1077 5-fluorocytosine 377 nM 0.707136354568385 0.235091233031498 no 777 0.239740872841533 1145 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3223 9129970 49.47 µM 0.70294652074606 0.236433329587042 no 778 0.241044539051957 1223 17248386 SGTC_3178 9107506 49.47 µM 0.702926601727753 0.236439720146244 no 779 0.241050746044782 1188 8897194 SGTC_299 1273-0059 1.44 µM 0.702514751876511 0.236571874008263 no 780 0.241179102619716 1147 2848077 SGTC_1029 k015-0030 64.7 µM 0.700556149513403 0.237200903760654 no 781 0.241790026157835 1160 2208316 SGTC_2025 5147754 141 µM 0.700174422854869 0.237323606967745 no 782 0.241909191325644 1203 315777 YLR208W SEC13 SGTC_1565 sinapyl alcohol 95.1 µM 0.700069645545379 0.237357292953666 no 783 0.241941905657702 1179 5280507 A phenol propionate derived from cinnamic acid. SGTC_1302 1159-0335 255 µM 0.699894006940068 0.237413766789811 no 784 0.241996750200724 1177 649284 SGTC_650 1328-0195 38 µM 0.697666532529758 0.238130615861303 no 785 0.242692881366758 1175 2780821 SGTC_2223 6903751 107.57 µM 0.696822727677702 0.238402479812418 no 786 0.242956870427147 1153 5598863 SGTC_1224 0823-0416 294 µM 0.694489215882248 0.239155193875825 no 787 0.24368773074247 1218 3598164 SGTC_1497 4476-2978 41.3 µM 0.693518926857071 0.239468559046656 no 788 0.243991976142327 1235 1528379 SGTC_1530 rhein 70.4 µM 0.693029053469254 0.239626854005891 no 789 0.244145659445857 1237 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2479 5617353 43.85 µM 0.692857771336572 0.239682214633416 no 790 0.244199406468641 1221 2731746 SGTC_2638 epoxomicin 18 µM 0.692568245571478 0.239775809019759 no 791 0.244290271942235 1188 9915668 A protesome inhibitor. SGTC_3180 9109287 49.47 µM 0.692409323966789 0.239827191748873 no 792 0.244340156033325 1193 18891271 SGTC_670 4204-0025 119 µM 0.69083126782913 0.24033773662177 no 793 0.24483579172873 1206 719039 SGTC_2978 9011784 42.97 µM 0.690067804423426 0.240584950543074 no 794 0.245075774315832 1267 2994934 SGTC_3183 9108214 49.47 µM 0.687295941269442 0.241483658690581 no 795 0.245948127988274 1111 4974831 SGTC_477 mead ethanolamide 10 µM 0.686590917062951 0.241712535890422 no 796 0.246170276905674 1095 16061185 SGTC_401 neomycin 50 µM 0.685525190166333 0.242058734063135 no 797 0.246506285249558 1166 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2560 caryophyllene 100 µM 0.685211579288778 0.242160660794265 no 798 0.246605209016952 1257 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_907 3448-6986 75.5 µM 0.684727798748412 0.242317940021636 no 799 0.246757851900558 1258 590582 SGTC_2004 4023728 41.89 µM 0.684177905847497 0.242496779873705 no 800 0.246931416027745 1183 360084 YDR527W RBA50 SGTC_2306 7482397 179.52 µM 0.683397479778344 0.24275071795131 no 801 0.24717785605381 1226 891448 SGTC_3310 9130229 44.1445 µM 0.683375724355378 0.242757798877215 no 802 0.247184727783858 1212 7761258 SGTC_2360 9040895 200 µM 0.68227839703027 0.243115100494903 no 803 0.247531465225228 1178 4914414 SGTC_1728 st035614 33.7865 µM 0.681696312633338 0.243304748826324 no 804 0.247715499779015 1198 15945546 SGTC_444 curcumin 90.4 µM 0.679403884717005 0.244052419365191 no 805 0.248440994569141 1186 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_2759 disulfiram 3.38 µM 0.679247447014475 0.244103486323589 no 806 0.248490544340673 1187 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_867 0518-0118 155 µM 0.678131693410949 0.244467875964625 no 807 0.248844098614271 1256 6848158 SGTC_792 4534-1957 155 µM 0.678007267193815 0.244508529995591 no 808 0.248883542745174 1191 1717904 SGTC_2607 solasodine 47.35 µM 0.677234870485422 0.244760978199851 no 809 0.249128473266988 1242 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_641 4092-0595 30 µM 0.677162523944111 0.244784630946863 no 810 0.249151421250676 1234 786260 SGTC_83 0170-0301 39.027 µM 0.676654078417372 0.244950895206668 no 811 0.249312729499137 1182 3089716 SGTC_1988 st071872 53.4 µM 0.67651821871567 0.244995332301836 no 812 0.249355841431265 1238 16414116 SGTC_3300 9124615 50.48 µM 0.675329977057764 0.24538416807089 no 813 0.249733071263689 1251 24824903 SGTC_586 0957-0265 8.15 µM 0.674746059857033 0.245575368425897 no 814 0.249918557835281 1140 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2394 5221648 200 µM 0.674109283334336 0.245783968449348 no 815 0.250120918966938 1288 788586 SGTC_1178 0988-0033 191 µM 0.673538683273133 0.245970970670798 no 816 0.250302323699274 1232 5392207 SGTC_985 1493-0307 8.71 µM 0.672894913232105 0.246182044441245 no 817 0.250507074290814 1221 3278274 SGTC_2781 5567276 71.43 µM 0.672545085383517 0.246296783698713 no 818 0.250618373988 1235 2853274 SGTC_2425 5628681 7.85 µM 0.67216273708583 0.246422222048541 no 819 0.25074005020281 1240 5714958 SGTC_2034 5197015 53.07 µM 0.672085663638918 0.246447511950791 no 820 0.250764581379328 1245 780676 SGTC_3095 9117207 49.47 µM 0.669811235455702 0.247194439647108 no 821 0.25148906517049 1197 17015229 SGTC_2822 7994718 71.43 µM 0.669747639643168 0.247215342049269 no 822 0.25150933851301 1203 1018011 SGTC_326 k292-0812 17.5 µM 0.668830783712316 0.247516795378495 no 823 0.251801713673472 1213 3579357 SGTC_988 1497-1057 103 µM 0.66851215520343 0.247621603307534 no 824 0.251903362761937 1246 3533044 SGTC_2347 9049783 174.81 µM 0.667230785673208 0.248043329273831 no 825 0.25231236474672 1240 6467988 YPL169C MEX67 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.667100838690256 0.248086118980633 no 826 0.252353862234906 1295 94937 An inhibitor of serotonin biosynthesis. SGTC_1508 1080-0625 72.9 µM 0.666810322415806 0.248181796128861 no 827 0.252446649201946 1182 767111 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.666526379476093 0.248275327461145 no 828 0.252537354105702 1262 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2819 7996655 46.38 µM 0.665901505181534 0.248481228388114 no 829 0.252737029186624 1140 6456960 SGTC_952 1185-0122 232 µM 0.665720927235624 0.248540747164676 no 830 0.25279474733743 1210 678600 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.664981438863133 0.24878456292349 no 831 0.253031182475872 1247 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1973 st070275 50.2 µM 0.664457387562401 0.248957424272538 no 832 0.253198806763693 1198 17118334 SGTC_3225 9130819 49.47 µM 0.664299261060814 0.249009595762857 no 833 0.253249396946558 1251 4547121 SGTC_2434 5670830 169.91 µM 0.663140021450647 0.249392247238311 no 834 0.253620440375559 1235 1549830 SGTC_2606 farnesol 9.78 µM 0.660935777205424 0.250120703852715 no 835 0.254326750383754 1277 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2722 naftopidil 47.16 µM 0.65648610646761 0.251594659034054 no 836 0.255755702013374 1243 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_1970 st070122 35.8 µM 0.656413752410683 0.251618664198787 no 837 0.255778972124129 1287 102928 SGTC_1886 st057356 49.9 µM 0.655015689093616 0.252082742119094 no 838 0.256228826416595 1220 24207747 SGTC_509 pifithrin 175 µM 0.654846640186314 0.252138887376244 no 839 0.256283249158503 1300 4817 A p53 inhibitor. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.654659046419086 0.252201199552886 no 840 0.256343649190539 1285 4213774 SGTC_2329 6138490 200 µM 0.653813344166551 0.252482213461036 no 841 0.256616034134361 1278 720019 SGTC_1439 4092-1168 46 µM 0.653538191287028 0.252573678110906 no 842 0.256704688238645 1259 2886240 SGTC_1511 0906-3109 28.5 µM 0.648271839856385 0.254327645514463 no 843 0.258404572089633 1306 2882180 SGTC_1575 cyproterone acetate 48 µM 0.647502080665427 0.254584548915401 no 844 0.25865352416829 1225 9880 An androgen receptor antagonist and liver toxin. SGTC_3215 9129942 49.47 µM 0.644896045169526 0.255455308721871 no 845 0.2594972773946 1215 17682944 SGTC_3328 9140624 29.0385 µM 0.644722019499596 0.25551351164346 no 846 0.259553672080849 1277 4904392 SGTC_1774 st048371 48.465 µM 0.644579584630339 0.255561154170287 no 847 0.2595998341744 1241 4242727 SGTC_3108 9121785 49.47 µM 0.644476125019037 0.255595762912499 no 848 0.259633367330922 1251 17140271 SGTC_3007 9078383 71.4286 µM 0.643985148297105 0.25576003512198 no 849 0.259792532366175 1256 6496995 SGTC_2053 5265679 138 µM 0.642678134876386 0.256197607430368 no 850 0.26021648579285 1248 764595 SGTC_2359 9039622 200 µM 0.641596792933664 0.256559922494305 no 851 0.260567507921215 1247 6463596 SGTC_2442 5158906 48.48 µM 0.641430335182193 0.256615719619928 no 852 0.260621564603716 1311 1893835 SGTC_2147 5545932 89.7195 µM 0.641085492988014 0.256731331836712 no 853 0.26073356949157 1280 797404 SGTC_2433 5607874 27.82 µM 0.640736912459422 0.256848224925011 no 854 0.26084681376014 1277 2252428 SGTC_2474 5321570 43.32 µM 0.639077301275208 0.257405139021848 no 855 0.261386322764015 1307 2841384 SGTC_2334 9017922 200 µM 0.638699631724704 0.257531960801699 no 856 0.261509176171462 1308 3163164 SGTC_2549 cedrol 20.94 µM 0.637967340974689 0.257777957144326 no 857 0.261747469948131 1266 6708665 A sedative which affects the nervous system. SGTC_3086 9117350 49.47 µM 0.635748668962184 0.258524013147852 no 858 0.262470124557244 1217 2679265 SGTC_741 4582-0002 126 µM 0.635031228778397 0.258765500365844 no 859 0.26270402389378 1270 2912688 SGTC_536 3852-0578 10.6 µM 0.634994531654093 0.258777855594588 no 860 0.262715990730088 1320 2869208 SGTC_2650 prasterone 100 µM 0.632451100033403 0.259634924258536 no 861 0.263546076042709 1260 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1556 plumbagin 1.48 µM 0.630619931601816 0.260252885258534 no 862 0.264144531655544 1236 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1277 0873-0036 22 µM 0.630120675938715 0.260421499530969 no 863 0.264307816537288 1348 5965735 SGTC_2097 5376186 200 µM 0.629936186778251 0.260483821532316 no 864 0.264368167944493 1260 742755 SGTC_2761 levamisole 97.89 µM 0.629737326732966 0.260551006740154 no 865 0.26443322831286 1348 26879 An alkaline phosphatase inhibitor. SGTC_2777 climbazole 1.536 µM 0.628665770169047 0.260913187465915 no 866 0.26478394605503 1279 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_282 k297-0036 65.7 µM 0.628434731243124 0.260991311378479 no 867 0.264859595489412 1308 5061378 SGTC_953 1188-0045 9.7 µM 0.628012154713512 0.261134233268424 no 868 0.264997988796208 1315 6144426 SGTC_553 k007-0256 45.7 µM 0.627664431151889 0.261251868893567 no 869 0.26511189539499 1341 6287000 SGTC_2565 isoliquiritigenin 100 µM 0.627097328897771 0.261443779194894 no 870 0.265297718970382 1253 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_230 MPP+ 141.667 µM 0.626960136620363 0.261490216634866 no 871 0.265342682979711 1263 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_85 0868-0259 160.055 µM 0.625122685511346 0.262112573017445 no 872 0.265945269996091 1282 83173 SGTC_538 2922-0838 53.3 µM 0.622245841392898 0.263088500815264 no 873 0.266890113591183 1355 777039 SGTC_2139 5578692 56.4705 µM 0.621874027365234 0.263214768715893 no 874 0.267012352327289 1274 650991 YMR113W FOL3 SGTC_1623 st003709 20.3 µM 0.62092829018232 0.263536080148471 no 875 0.267323403193259 1303 16192618 SGTC_1718 roemerine 11.9335 µM 0.619356476917293 0.264070541523461 no 876 0.267840773197106 1256 235224 An aporphine alkaloid with mutagenic activity. SGTC_1193 1488-0126 41.5 µM 0.619089051979095 0.264161528578005 no 877 0.267928847602322 1314 1384710 SGTC_1372 2752-0194 270 µM 0.617711955842126 0.264630316197288 no 878 0.268382614733221 1284 823334 SGTC_2478 5763493 32.33 µM 0.616810424396206 0.264937442304583 no 879 0.268679887665653 1285 1365576 YLR208W SEC13 SGTC_2953 9074162 66.49 µM 0.616702031739422 0.264974380793004 no 880 0.268715640433517 1324 16451992 SGTC_2217 6934799 96.0675 µM 0.616307394864568 0.265108888849373 no 881 0.268845829593536 1265 675606 SGTC_589 1227-0070 34.1 µM 0.615114769787976 0.265515593918518 no 882 0.269239464349818 1327 2841384 SGTC_2933 9026794 32.47 µM 0.613809225744216 0.265961168845341 no 883 0.269670700034948 1350 17586027 SGTC_1421 4029-0249 71.4 µM 0.613770655632699 0.265974338368898 no 884 0.269683445430645 1410 2894095 SGTC_2695 st077686 51.995 µM 0.612430627353371 0.266432087675618 no 885 0.270126441642327 1293 2876092 SGTC_1082 camptothecin 424.86 nM 0.611346337775176 0.266802768964367 no 886 0.270485160144171 1247 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1690 st023502 41.2 µM 0.610135509670822 0.267217017200496 no 887 0.270886022845834 1326 24207482 SGTC_2856 9022925 19.48 µM 0.609927704936238 0.267288143930868 no 888 0.270954849497407 1338 4944862 SGTC_217 ketoconazole 989 nM 0.606995974834054 0.268292624002079 no 889 0.271926791701873 1274 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2273 7815444 169.05 µM 0.606819830538513 0.268353035621987 no 890 0.271985243145434 1347 2824616 SGTC_3142 9086498 49.47 µM 0.606792085294991 0.268362551939022 no 891 0.271994450652643 1269 25236367 SGTC_2043 5101342 149 µM 0.605717441001111 0.268731273802683 no 892 0.272351200209374 1310 678451 SGTC_1117 retinoic acid 1.10837 µM 0.60517430299091 0.268917726991785 no 893 0.272531594066767 1373 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2256 7954252 200 µM 0.602747866236692 0.269751487975696 no 894 0.273338216681368 1291 2972920 SGTC_145 3737-0113 38.366 µM 0.6017908568343 0.270080686744188 no 895 0.273656681008756 1337 6849351 SGTC_2596 sinensetin 100 µM 0.601191459907248 0.270286973794285 no 896 0.273856235967059 1330 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_3233 9132340 49.47 µM 0.601041411150718 0.27033862655049 no 897 0.27390620239139 1293 17682950 SGTC_42 0133-0086 60.653 µM 0.599650688143191 0.270817603467995 no 898 0.274369529251226 1276 162923 Model of phenazepam hydroxylation. SGTC_1155 4088-0394 48.2 µM 0.599622388336652 0.270827354559617 no 899 0.274378961499131 1297 2326248 SGTC_2059 5238311 157 µM 0.598634754784365 0.271167767162672 no 900 0.274708237283031 1330 703021 SGTC_732 3970-1727 52.7 µM 0.597823909413361 0.271447404685265 no 901 0.274978717687464 1382 1275699 SGTC_2173 5763948 167 µM 0.596530353433476 0.271893812573261 no 902 0.275410491313597 1343 2867177 SGTC_156 3474-0145 5.642 µM 0.595680863168856 0.272187171336993 no 903 0.275694222419714 1296 2265471 SGTC_3195 9113082 49.47 µM 0.59440202793045 0.272629094440746 no 904 0.276121626219991 1326 17018038 SGTC_2266 7929956 200 µM 0.593785331818217 0.272842331396227 no 905 0.276327850473127 1335 2967153 SGTC_1656 st012921 11 µM 0.592937175776054 0.273135736042392 no 906 0.276611598691374 1341 6732821 SGTC_1828 st055811 49 µM 0.592332102197899 0.273345146107595 no 907 0.276814111597132 1315 5877589 SGTC_2555 cholic acid 100 µM 0.591767508779379 0.2735406180669 no 908 0.277003141615717 1341 6708657 Influences liver metabolism. SGTC_2234 tolnaftate 200 µM 0.590575923715248 0.27395339227731 no 909 0.277402300329111 1335 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_2058 5236698 133 µM 0.588284462253268 0.274748036410483 no 910 0.278170686500281 1358 766665 SGTC_3315 9136395 68.55 µM 0.587803403661276 0.274915004465614 no 911 0.278332129591225 1385 16876844 SGTC_3271 9137798 49.47 µM 0.586422695198928 0.275394504715695 no 912 0.278795748349697 1324 6498326 SGTC_2745 rifampicin 24.3 µM 0.585963775460895 0.275553972029675 no 913 0.278949929087839 1349 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_468 gf-109203x 121 µM 0.585803805884776 0.275609569586171 no 914 0.279003682933193 1302 2396 A protein kinase C inhibitor. SGTC_3269 9137823 49.47 µM 0.585678832195398 0.275653008131129 no 915 0.279045680775785 1303 17682936 SGTC_932 2857-0803 154 µM 0.58441296002208 0.276093191522429 no 916 0.279471254714218 1484 674898 SGTC_11 0438-0307 1.3 µM 0.583864231869523 0.276284108641756 no 917 0.279655829672585 1408 4011476 SGTC_462 ag-879 158 µM 0.58152681903427 0.277098081610901 no 918 0.280442724222493 1381 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_3083 9117465 49.47 µM 0.580816519249232 0.277345666365972 no 919 0.280682060196012 1335 16420915 SGTC_518 1021-0119 62.6 µM 0.580033599488045 0.277618689075093 no 920 0.280945979935463 1318 1097762 SGTC_354 2783-3500 4.88 µM 0.579938416179114 0.277651890704824 no 921 0.280978074098668 1322 6740761 SGTC_1972 st070201 17.4 µM 0.578653435200264 0.278100304658103 no 922 0.281411520753217 1382 2829099 SGTC_761 k216-0224 480 µM 0.576986337519486 0.278682590075974 no 923 0.281974342495537 1444 1340404 SGTC_3256 9138902 49.47 µM 0.576482908694112 0.278858544780851 no 924 0.282144409480636 1411 17228773 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.575634651341029 0.27915514361837 no 925 0.282431077167644 1374 688798 SGTC_1334 1486-0610 236 µM 0.574590379096234 0.279520490849924 no 926 0.282784180146478 1392 3742339 SGTC_2158 5657123 3.6195 µM 0.574436873801814 0.279574215505699 no 927 0.282836103235707 1359 2858827 SGTC_1115 galangin 695.678 nM 0.573799648919617 0.279797288675204 no 928 0.283051693179053 1412 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1756 st041558 35.5 µM 0.573735087427342 0.279819894518603 no 929 0.283073540430212 1481 3955792 SGTC_1613 st002381 52.1 µM 0.570581655983214 0.280925127918962 no 930 0.284141628067131 1370 551167 SGTC_3130 9127414 49.47 µM 0.570091149682339 0.281097232924563 no 931 0.284307938775928 1372 1494646 SGTC_2214 7179297 48.276 µM 0.56931345473713 0.281370208780961 no 932 0.284571718780365 1421 769744 SGTC_1380 2291-0730 164 µM 0.569130205885223 0.281434548910065 no 933 0.284633890473096 1354 2999191 SGTC_2778 tioconazole 65.09 nM 0.568408038434598 0.281688176738895 no 934 0.284878966709958 1342 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3291 9121177 71.43 µM 0.568340069768769 0.281712053253737 no 935 0.28490203787881 1346 17015612 SGTC_1984 st072354 53.1 µM 0.567783537261663 0.281907592631193 no 936 0.285090979849446 1350 5762938 SGTC_2684 capsaicin 100 µM 0.567416988268424 0.282036416434119 no 937 0.285215455314038 1371 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1604 st002052 72.4 µM 0.566970672665878 0.282193312511598 no 938 0.2853670534794 1411 6254834 YHR062C RPP1 SGTC_1007 4101-0031 70 µM 0.566481154893149 0.282365444007261 no 939 0.285533370062396 1405 1146276 SGTC_3347 9188721 44.724 µM 0.56248090706407 0.283773960007161 no 940 0.28689420428654 1392 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2159 5658611 73.75 µM 0.562139925349175 0.283894177551755 no 941 0.287010343990998 1405 793844 SGTC_1144 3486-0183 12.5 µM 0.5608474989136 0.284350060482224 no 942 0.287450751525553 1383 6744069 SGTC_1799 st045822 46.1415 µM 0.560254772117061 0.284559252412238 no 943 0.287652836090415 1393 3674992 SGTC_1448 4255-0083 152 µM 0.558033712198429 0.285343787332864 no 944 0.288410681928783 1526 5399660 SGTC_605 1315-0399 119 µM 0.557902910344064 0.285390021983288 no 945 0.288455342041225 1452 24020461 SGTC_1842 st055362 61.2 µM 0.55672878031194 0.285805202459394 no 946 0.288856375036187 1444 676032 SGTC_2790 5423970 71.43 µM 0.556660044495637 0.285829516815519 no 947 0.28887986040302 1488 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_626 0214-0009 33 µM 0.555621811957223 0.286196896979243 no 948 0.289234708617724 1490 3437874 SGTC_1809 st050081 57.6 µM 0.555584961932107 0.286209940536913 no 949 0.289247307022555 1464 5036894 SGTC_1564 D-Arginine 115 µM 0.555120474338768 0.28637437631577 no 950 0.289406129643508 1323 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_810 3825-7150 143 µM 0.554343586603918 0.286649506749198 no 951 0.289671863027712 1453 22330411 YGL099W LSG1 SGTC_1716 st033144 30.6155 µM 0.553729464458849 0.286867083331296 no 952 0.289882003676317 1449 674617 SGTC_2258 7960471 200 µM 0.553590601962399 0.286916291601224 no 953 0.289929529630202 1350 2974708 SGTC_1456 k015-0012 13 µM 0.552700506361431 0.287231806942689 no 954 0.290234253284866 1488 2989616 SGTC_87 0100-0052 35.5 µM 0.551129804906494 0.287788979273774 no 955 0.290772347578052 1478 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_797 k781-0471 270 µM 0.549915487029322 0.288220081881561 no 956 0.291188670665886 1463 23738129 SGTC_1787 fluconazole 80 µM 0.548313321423698 0.28878934239053 no 957 0.291738390949829 1322 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2963 9082507 9 µM 0.54663960489754 0.289384590133109 no 958 0.292313177091276 1449 16459611 SGTC_874 0599-0792 117 µM 0.545894459844898 0.289649782036626 no 959 0.292569243422228 1462 765305 SGTC_2046 4110841 106 µM 0.545894006132181 0.289649943544548 no 960 0.292569399370666 1412 44119630 YMR134W ERG29 SGTC_2137 5261020 140 µM 0.545231289124605 0.289885895745516 no 961 0.292797227201442 1381 763655 SGTC_266 formosanin C 406 nM 0.542541022013722 0.290844656650429 no 962 0.293722927883356 1426 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_346 4513-0042 7.16 µM 0.542236831148438 0.290953157800292 no 963 0.293827682846755 1415 2827372 SGTC_1101 ebselen 5.29 µM 0.542093127394257 0.291004421743885 no 964 0.293877176475629 1482 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_863 0466-0191 129 µM 0.541757350335744 0.291124221117037 no 965 0.293992837927391 1419 765160 YPR165W RHO1 SGTC_2845 9003024 42.97 µM 0.541378328915861 0.291259476986832 no 966 0.294123420572273 1504 2990173 SGTC_2074 5212007 75.395 µM 0.541051862829201 0.291376001706689 no 967 0.294235918032726 1407 758611 SGTC_2109 5483026 200 µM 0.538452584207054 0.292304530788448 no 968 0.295132315815453 1463 759335 SGTC_3155 9099265 49.47 µM 0.536978904242727 0.292831577686155 no 969 0.295641093025941 1436 25236499 SGTC_1341 1486-1360 280 µM 0.534531402344864 0.293707875668091 no 970 0.296486964686419 1413 3976547 SGTC_2081 5214970 32.255 µM 0.533657572895026 0.294021033303943 no 971 0.296789233944237 1491 2063512 SGTC_1147 3809-1045 12.3 µM 0.533574760857199 0.294050718979538 no 972 0.296817887048686 1388 325925 SGTC_2473 5854593 8.94 µM 0.533059947436298 0.29423529549276 no 973 0.296996041754087 1425 2872951 SGTC_1507 4075-3230 155 µM 0.533033447021118 0.294244798158415 no 974 0.29700521372759 1363 659771 SGTC_916 4466-0038 42 nM 0.532306616290692 0.294505484394949 no 975 0.297256825266819 1466 5722064 YGL116W CDC20 SGTC_3249 9135183 49.47 µM 0.532287763385351 0.294512247625197 no 976 0.297263352990896 1465 4902779 SGTC_1090 efavirenz 20.7 µM 0.53142888760622 0.294820433925324 no 977 0.297560803872071 1447 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2048 5246248 200 µM 0.527201326549096 0.296339551794457 no 978 0.299026893785389 1457 677046 SGTC_821 1114-0266 29.2 µM 0.527152274803377 0.296357198931895 no 979 0.299043923837474 1423 3123235 SGTC_137 0438-0332 85.389 µM 0.526442377413718 0.296612649615038 no 980 0.299290439166486 1415 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_2100 5377183 190 µM 0.526328188588793 0.296653748930598 no 981 0.299330100397844 1526 2844202 SGTC_1113 artemisinin 1.17947 µM 0.523456858133795 0.297688066286876 no 982 0.300328182871553 1477 2240 An anti-malaria and mitochondrial poison. SGTC_1315 1237-0019 3.69 µM 0.522127918128452 0.298167336539053 no 983 0.300790634695813 1515 825140 SGTC_1853 st056710 91.2 µM 0.521614310469826 0.298352658638279 no 984 0.30096944873753 1613 269167 SGTC_2446 5162541 200 µM 0.521541890446093 0.298378793756284 no 985 0.300994665840188 1397 1549321 SGTC_1519 esterone 74 µM 0.518077578501078 0.299630218392127 no 986 0.302202071604935 1385 698 A steroid. SGTC_2616 abietic acid 100 µM 0.517685056751635 0.299772160157964 no 987 0.302339012975316 1489 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_255 tunicamycin 200.472 nM 0.517293982745968 0.299913608671683 no 988 0.302475476938731 1466 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3212 9128307 49.47 µM 0.516713592827409 0.300123586985574 no 989 0.302678052943691 1378 27243542 SGTC_2892 9047358 58.44 µM 0.516160183625069 0.300323865891438 no 990 0.302871268342702 1426 6466771 SGTC_1111 tnp00062 510.699 nM 0.51528316669207 0.300641382145206 no 991 0.303177580076167 1576 676306 SGTC_2506 ethyl hematommate 54.16 µM 0.51502188192883 0.300736007281256 no 992 0.303268864599839 1401 3940691 An allergen. SGTC_2492 derrusnin 100 µM 0.514871177835977 0.300790591374527 no 993 0.303321521367242 1397 1715307 Part of coumarin class of compounds. SGTC_1022 4477-0945 21.3 µM 0.513144230823177 0.301416399733096 no 994 0.303925216794555 1440 4648966 SGTC_2598 perillyl alcohol 100 µM 0.5128552909645 0.301521162513034 no 995 0.304026274899902 1514 10819 An apoptosis inducer. SGTC_1402 3909-7673 35.9 µM 0.512685457472386 0.301582747776919 no 996 0.304085681969524 1423 5328014 SGTC_698 k064-0052 127 µM 0.5123956739884 0.301687842540652 no 997 0.304187059004466 1529 5088751 SGTC_1594 piperine 70.1 µM 0.510048454981641 0.302539706456966 no 998 0.305008757720702 1433 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1442 4112-3290 3 µM 0.508669304411069 0.303040736696066 no 999 0.305492020824647 1449 704353 SGTC_1685 st024049 53.0905 µM 0.508112380295366 0.303243166276191 no 1000 0.305687266731728 1458 1941139 SGTC_1496 4469-0713 57.4 µM 0.507627268910174 0.303419542767233 no 1001 0.305857381634077 1521 746691 SGTC_1672 st016598 6.51 µM 0.506530022748446 0.303818647804398 no 1002 0.30624230947228 1433 4665860 YNL267W PIK1 SGTC_20 0481-0013 4.944 µM 0.503178123690579 0.305039293108093 no 1003 0.307419521987327 1455 182045 SGTC_3084 9116877 49.47 µM 0.50072908249464 0.30593252336871 no 1004 0.308280900862397 1439 27241325 SGTC_2019 4016004 108 µM 0.500462177295768 0.306029940689181 no 1005 0.308374840930653 1424 45595336 SGTC_539 4859-0462 2.54 µM 0.500261232656569 0.306103292219978 no 1006 0.308445573772629 1573 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_2891 9063876 19.48 µM 0.499105520659188 0.306525316727045 no 1007 0.308852524277162 1494 6472478 SGTC_1627 st003713 25.6 µM 0.499097210148292 0.306528352357339 no 1008 0.308855451433642 1477 16195070 YER133W GLC7 SGTC_2670 beta-carotene 100 µM 0.499025393067141 0.306554585967497 no 1009 0.308880747596588 1443 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_333 3486-0131 40.1 µM 0.497770674688379 0.307013074002639 no 1010 0.309322843813805 1576 6744690 SGTC_986 1493-0483 84 µM 0.497619068209944 0.307068493154346 no 1011 0.309376280610192 1480 40079 SGTC_3290 9121031 71.43 µM 0.497615224832222 0.307069898143243 no 1012 0.309377635339483 1451 17014854 SGTC_3047 9092122 49.47 µM 0.496955140302137 0.307311241293773 no 1013 0.309610343020834 1447 17173831 SGTC_3187 9109394 49.47 µM 0.496644370092278 0.307424895437241 no 1014 0.309719929086616 1399 17098090 SGTC_3219 9131112 49.47 µM 0.496545963705519 0.307460888242984 no 1015 0.30975463339342 1454 17612988 YMR079W SEC14 SGTC_524 r073-0010 27.8 µM 0.496444829791685 0.307497880592144 no 1016 0.309790301365488 1427 2772106 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.495643948427329 0.307790892819505 no 1017 0.310072819927692 1467 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3075 9116269 49.47 µM 0.494436624210651 0.308232838854093 no 1018 0.310498927050685 1520 17015205 YNL244C SUI1 SGTC_1236 0330-0013 258 µM 0.494117411613302 0.308349734465227 no 1019 0.310611630937494 1478 4617066 SGTC_3351 9150312 21.596 µM 0.494060664731113 0.308370517200932 no 1020 0.310631668330802 1476 4904905 SGTC_2831 7999036 19.48 µM 0.493833624081386 0.308453673742172 no 1021 0.310711842280837 1658 2988270 SGTC_378 3970-0959 8.33 µM 0.49236195296996 0.308992930261658 no 1022 0.311231745422689 1496 6615653 SGTC_2951 9072950 58.06 µM 0.490769242082823 0.309577002891505 no 1023 0.311794833366805 1478 16488155 SGTC_1426 4048-4480 71.7 µM 0.490609627760866 0.309635562578174 no 1024 0.311851287800121 1563 14224343 SGTC_917 harmaline 728.087 nM 0.489676923107954 0.30997785209676 no 1025 0.312181267064872 1542 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2576 guaiol 23.12 µM 0.488963645382352 0.310239726213823 no 1026 0.312433717552764 1591 227829 SGTC_2697 mebhydrolin 72.4 µM 0.488196500468205 0.310521484663868 no 1027 0.312705331548249 1620 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.487721178375927 0.310696117678272 no 1028 0.312873674319922 1541 804 An inhibitor of viral and cellular DNA polymerases. SGTC_1119 parthenolide 318.541 nM 0.486055543819252 0.31130840715081 no 1029 0.313463892747986 1609 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_251 melphalan 456.522 µM 0.486027342477234 0.311318778503416 no 1030 0.313473890026333 1593 460612 A DNA alkylator. SGTC_3136 9095672 49.47 µM 0.485586685972113 0.311480854211705 no 1031 0.313630119030315 1487 17217380 SGTC_1452 4194-0072 190 µM 0.485061956259119 0.31167390013532 no 1032 0.313816198698823 1625 1343545 SGTC_770 0389-1121 67.2 µM 0.484659250574174 0.311822089030114 no 1033 0.31395903833049 1602 6753108 SGTC_1650 st011916 45.8 µM 0.483430290726065 0.312274513821203 no 1034 0.314395122462155 1575 242528 SGTC_1036 k216-0215 33.5 µM 0.482425013933287 0.312644803371467 no 1035 0.314752027617111 1469 622330 SGTC_1087 pterostilbene 9.05 µM 0.482036376734364 0.312788007005763 no 1036 0.314890052571546 1608 5281727 Similar to reservatol, lowers cholesterol. SGTC_3165 9101544 49.47 µM 0.481877804242966 0.312846445344657 no 1037 0.314946377205935 1531 5002184 SGTC_2388 9080168 200 µM 0.481131637618829 0.313121491455908 no 1038 0.315211471869408 1450 15943073 SGTC_2865 9030313 51.95 µM 0.480922030318941 0.313198773981119 no 1039 0.315285957321876 1459 42562754 SGTC_2634 4'-methoxyflavone 100 µM 0.48089194340943 0.313209867743204 no 1040 0.315296649536581 1509 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_3096 9117468 49.47 µM 0.479798452454748 0.313613178634041 no 1041 0.315685356690363 1448 41316311 SGTC_583 1488-1091 88.9 µM 0.475816750722409 0.315083625308075 no 1042 0.317102467565176 1578 4303273 SGTC_1389 3405-0187 19 µM 0.474905896734273 0.31542041802409 no 1043 0.317427024136229 1478 799890 SGTC_1927 st060202 13.8 µM 0.471682639670284 0.316613463583128 no 1044 0.318576665179769 1557 688887 SGTC_2719 novobiocin 32.65 µM 0.471658375117638 0.316622452043 no 1045 0.318585326277554 1611 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_3107 9121808 49.47 µM 0.470418084259317 0.317082044359058 no 1046 0.319028173174074 1528 662681 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.469538591163285 0.317408113447097 no 1047 0.319342353572116 1570 5393153 SGTC_1023 4482-3888 16 µM 0.468959163382872 0.317623011807987 no 1048 0.319549412873536 1625 3303168 SGTC_1857 st056007 79.3 µM 0.46680807451947 0.318421345531474 no 1049 0.320318599184252 1529 619834 SGTC_32 0928-0142 34.1 µM 0.46608176421704 0.318691091877207 no 1050 0.320578487856465 1536 2244242 SGTC_176 1486-1328 72.834 µM 0.465786676036964 0.318800712936018 no 1051 0.320684101582307 1506 22310231 SGTC_1892 st058411 7.36 µM 0.464967481285804 0.319105115209625 no 1052 0.320977372078757 1606 3934738 SGTC_3307 9126885 69.2785 µM 0.46402318975393 0.319456153233984 no 1053 0.32131556564877 1479 24824909 SGTC_2870 9038528 12.99 µM 0.461878552660987 0.320254017630568 no 1054 0.322084207548702 1515 6463316 SGTC_1766 st045414 44.774 µM 0.459608090562534 0.321099598871847 no 1055 0.322898775417879 1539 253960 SGTC_987 1497-1013 404 µM 0.457136384261913 0.32202118453076 no 1056 0.323786509918765 1568 1676435 SGTC_1698 5-fluorocytosine 1.055 µM 0.456601006841183 0.32222094670728 no 1057 0.323978927692365 1610 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2412 st077135 33.4 µM 0.455781563178179 0.322526800276839 no 1058 0.3242735316243 1632 13258915 SGTC_3167 9103034 49.47 µM 0.453275349089768 0.323462978074847 no 1059 0.32517524054402 1551 5127859 SGTC_2723 salbutamol 83.58 µM 0.452119730222831 0.323895028191843 no 1060 0.32559136533198 1574 9884233 β2-adrenoceptor agonist SGTC_1708 st033234 31.827 µM 0.450723416091378 0.324417383484367 no 1061 0.326094451751884 1610 674664 SGTC_2561 acetosyringone 100 µM 0.450666469007886 0.324438694493969 no 1062 0.326114976286435 1518 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_2907 7721985 69.9 µM 0.448684627315883 0.325180706533538 no 1063 0.326829587848887 1501 3267881 SGTC_750 4073-0104 132 µM 0.447793704300915 0.325514499058529 no 1064 0.327151043723659 1462 22330957 SGTC_1109 tnp00067 928.257 nM 0.443722542163754 0.327041575540807 no 1065 0.328621597807108 1548 676295 SGTC_2717 st081029 62.2815 µM 0.443371200932555 0.327173498531698 no 1066 0.328748631515152 1601 5292846 SGTC_782 0083-0095 30.5 µM 0.443217016404575 0.327231399164894 no 1067 0.328804385938589 1565 3591729 An indicator and reagent. SGTC_3147 9097027 49.47 µM 0.443115499235225 0.327269523991426 no 1068 0.328841097482028 1670 25236841 SGTC_1608 st001473 40.5 µM 0.44309732382408 0.327276349966883 no 1069 0.328847670410489 1509 7292267 SGTC_2731 amoxapine 43.43 µM 0.439609933411982 0.328587144277383 no 1070 0.330109822497586 1657 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2941 9056145 11.23 µM 0.439405681166532 0.328663981544811 no 1071 0.330183805371762 1502 2119517 SGTC_1881 5652484 16 µM 0.438991102881614 0.328819963240844 no 1072 0.330333991543568 1663 2255129 SGTC_1141 3253-0389 52.6 µM 0.434818869829094 0.330391388215936 no 1073 0.33184695350459 1637 5402031 SGTC_284 0988-0104 32.6 µM 0.434586417224166 0.330479027240527 no 1074 0.331931327954138 1629 4666532 SGTC_3331 9141060 1.957 µM 0.433432861286842 0.330914077098166 no 1075 0.332350165785764 1531 4906567 YPR165W RHO1 SGTC_53 0973-0023 39.979 µM 0.431857779919976 0.331508469076824 no 1076 0.332922390978491 1676 674768 SGTC_2375 9072683 200 µM 0.431839868965912 0.331515230617893 no 1077 0.332928900248055 1723 16798029 SGTC_2435 5706476 10.6 µM 0.431828769847127 0.331519420659405 no 1078 0.332932933958844 1694 5725375 SGTC_2065 5221596 34.26 µM 0.431729941855064 0.331556730261682 no 1079 0.33296885149489 1605 788581 SGTC_989 1501-0895 10.3 µM 0.431493863367846 0.331645861516612 no 1080 0.333054656845877 1669 2830112 SGTC_1009 4106-0057 9.87 µM 0.431401067652221 0.331680899079308 no 1081 0.333088386873892 1589 2928005 SGTC_885 0865-0106 16.8 µM 0.43099286071667 0.331835046265925 no 1082 0.333236780783719 1516 2793380 SGTC_3106 9121286 49.47 µM 0.430650481290542 0.331964357612316 no 1083 0.333361264804674 1634 15943471 SGTC_188 3229-0966 278.469 µM 0.430266213701128 0.332109513302082 no 1084 0.333501000594585 1710 5722370 SGTC_1875 nocodazole 6 µM 0.428230941173825 0.332878749817321 no 1085 0.334241495804037 1637 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1548 st061468 90.8 µM 0.427803930339765 0.333040229109543 no 1086 0.334396937603775 1623 390799 SGTC_1741 st038134 10.228 µM 0.427400285463731 0.333192900752581 no 1087 0.334543899765672 1700 1272587 SGTC_1789 tunicamycin 25 nM 0.427007790365349 0.333341381697911 no 1088 0.33468682674496 1553 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1652 st011932 78 µM 0.425539675127859 0.33389700128702 no 1089 0.335221652740193 1664 1551076 SGTC_2517 totarol 10 µM 0.424798466143765 0.334177656062333 no 1090 0.335491797967708 1521 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2744 captopril 92.04 µM 0.422888640124259 0.334901228382786 no 1091 0.336188255689883 1691 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_62 0180-0423 3.232 µM 0.422223463990844 0.335153386603123 no 1092 0.336430958213543 1585 30102 YGL099W LSG1 SGTC_265 mycophenolic acid 32.932 µM 0.421073697871358 0.335589420742634 no 1093 0.336850633583995 1665 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1423 4048-0112 5.59 µM 0.420902831719698 0.335654238469608 no 1094 0.336913018681039 1674 X1423 SGTC_597 k018-0003 82.8 µM 0.419866510505965 0.336047469529991 no 1095 0.337291486944332 1680 6786234 SGTC_448 monastrol 171 µM 0.419582450619048 0.336155287136566 no 1096 0.337395255420789 1624 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2982 9019404 25.97 µM 0.417495618680923 0.336947776637044 no 1097 0.338157964162952 1425 22333232 SGTC_1166 k206-0078 225 µM 0.415503803149785 0.337704858739558 no 1098 0.338886565816877 1571 5404595 SGTC_1097 itavastatin 7.23 µM 0.414776597845833 0.337981430866237 no 1099 0.339152726338634 1613 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_622 1348-1566 26.3 µM 0.414691816339807 0.338013680829281 no 1100 0.339183761992397 1689 7340407 SGTC_1626 st003712 1.76 µM 0.414199260704859 0.33820106714856 no 1101 0.339364091599115 1647 24207035 SGTC_2792 7535235 81.82 µM 0.413939345934628 0.338299964468569 no 1102 0.339459263861797 1528 1281891 SGTC_1529 apigenin 74 µM 0.413858955428672 0.33833055523802 no 1103 0.339488702301616 1694 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_836 0330-0104 1.35 µM 0.412663321544641 0.338785652244537 no 1104 0.339926650573959 1633 46494820 SGTC_857 0438-0306 1.35 µM 0.408973517872463 0.340191593133939 no 1105 0.341279547763868 1621 4686136 SGTC_3023 9089636 49.47 µM 0.40856699589556 0.340346628260631 no 1106 0.341428727653523 1685 17249241 SGTC_1742 st038235 28.8875 µM 0.406893048503489 0.340985305043125 no 1107 0.342043270902952 1629 564103 YBR002C RER2 SGTC_2935 9038016 29.96 µM 0.406326777982598 0.341201462826038 no 1108 0.342251256235578 1645 6463195 SGTC_1021 4476-0760 85.3 µM 0.405935819753298 0.341350730509969 no 1109 0.342394879100348 1575 746768 SGTC_2566 crystal violet carbinol 226 nM 0.405863705468945 0.341378266425094 no 1110 0.342421373577483 1516 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2368 9071271 200 µM 0.404672938188395 0.341833067647232 no 1111 0.342858968375269 1568 27209959 SGTC_3151 9099821 49.47 µM 0.404279161189304 0.341983517251709 no 1112 0.343003723827303 1578 17174189 SGTC_3281 9140613 49.47 µM 0.402201031368265 0.342777919405602 no 1113 0.343768041628041 1529 16013766 SGTC_3048 9093155 49.47 µM 0.400827345475239 0.343303417497097 no 1114 0.344273622200842 1663 25236002 SGTC_1714 st033236 13.627 µM 0.398005729531233 0.344383765302323 no 1115 0.345312981176326 1730 2916566 SGTC_2645 abamectin 100 µM 0.396843874113784 0.344828989510388 no 1116 0.345741297367368 1690 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1702 st027038 51 µM 0.395419169555114 0.345375231165031 no 1117 0.346266782053386 1646 5521182 SGTC_995 3931-2021 34.6 µM 0.394709128398672 0.345647586275344 no 1118 0.346528782587756 1673 730143 SGTC_3202 9113761 49.47 µM 0.392802740203593 0.346379226983722 no 1119 0.347232590315216 1780 4798415 SGTC_2006 4011487 200 µM 0.39236885626747 0.346545824789586 no 1120 0.347392846986549 1759 45595294 SGTC_1760 st045453 10.4495 µM 0.391048932694061 0.347052816390247 no 1121 0.347880533393852 1715 3323419 YIL048W NEO1 SGTC_335 4077-0256 27.6 µM 0.388806028259062 0.347914958979054 no 1122 0.348709820560791 1727 3121989 SGTC_3012 9080433 71.4286 µM 0.388792735065254 0.347920071055558 no 1123 0.348714737720887 1761 17688859 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.387649863428383 0.348359680981381 no 1124 0.349137581538671 1638 15053 SGTC_133 0724-0033 378.92 µM 0.385621372797112 0.349140449164233 no 1125 0.349888551035699 1611 280309 SGTC_197 4544-0043 41.561 µM 0.385248057449169 0.349284208351619 no 1126 0.350026820580231 1643 896523 SGTC_713 1488-1073 324 µM 0.384921572931823 0.349409951285193 no 1127 0.350147761097643 1705 3312542 SGTC_466 geldanamycin 89.2 µM 0.384799316913687 0.349457041479272 no 1128 0.350193052627697 1721 5288382 HSP90 inhibitor. SGTC_1821 st053465 65.6 µM 0.384141451477106 0.349710475811985 no 1129 0.350436805067677 1616 675086 SGTC_1669 st015249 58.4 µM 0.383848861259107 0.349823214018805 no 1130 0.350545235455524 1768 722793 SGTC_3040 9091894 49.47 µM 0.38384054595374 0.349826418190348 no 1131 0.3505483171849 1703 25236966 SGTC_2229 7354935 190 µM 0.383174699598431 0.350083026262695 no 1132 0.350795117939329 1694 318112 SGTC_3354 9151612 71.43 µM 0.383077145551949 0.350120628010491 no 1133 0.350831282341787 1756 27261949 SGTC_280 3448-3607 3.04 µM 0.382729172358352 0.350254764606067 no 1134 0.350960290996748 1745 626179 SGTC_1659 st012954 42.1 µM 0.382037834962573 0.350521316538196 no 1135 0.35121665052186 1686 24207262 SGTC_3283 9109332 35.8195 µM 0.381746116606895 0.350633813513391 no 1136 0.351324844912725 1606 17027281 SGTC_862 0452-0056 10.2 µM 0.381732249306593 0.350639161563919 no 1137 0.35132998840684 1667 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_212 3807-4682 38.772 µM 0.380394958712771 0.35115503877422 no 1138 0.35182612812113 1754 3125501 YBL034C STU1 SGTC_2362 9071156 126 µM 0.379384315976691 0.351545089445342 no 1139 0.352201247808696 1707 653133 SGTC_1311 1190-0148 100 µM 0.379032321621344 0.351680975999757 no 1140 0.35233193114639 1755 1961333 SGTC_3004 9076122 71.4286 µM 0.37863826412996 0.351833123408811 no 1141 0.352478251758517 1732 44782551 SGTC_3077 9117319 49.47 µM 0.376889695817791 0.352508539654945 no 1142 0.353127789647516 1678 17154678 SGTC_1034 k072-0165 12.7 µM 0.376570537091612 0.352631870782934 no 1143 0.353246393293281 1797 5835461 SGTC_1472 k841-0093 193 µM 0.3763062070253 0.35273402643763 no 1144 0.353344632669393 1742 X1472 SGTC_1048 3161-0300 24.5 µM 0.374518688816729 0.353425127090798 no 1145 0.354009227488595 1616 2165101 SGTC_1725 st036284 20.55 µM 0.373580796169576 0.353787934149202 no 1146 0.354358111780055 1813 707914 SGTC_358 0075-0058 9.45 µM 0.373256800140106 0.353913297125465 no 1147 0.354478662662483 1912 1069125 SGTC_859 0439-0102 54.6 µM 0.373078570910182 0.353982265671448 no 1148 0.354544983552796 1778 610143 SGTC_865 0488-0499 301 µM 0.372909079871954 0.354047857284239 no 1149 0.354608056965089 1707 9634651 SGTC_973 1325-0077 65.9 µM 0.372901107502262 0.354050942631233 no 1150 0.354611023854707 1785 2835149 SGTC_2820 7989630 71.43 µM 0.372589571339385 0.354171516188108 no 1151 0.354726967857902 1796 2984098 SGTC_2869 9037858 32.47 µM 0.372435863053261 0.354231011153344 no 1152 0.354784178227225 1612 27187042 SGTC_387 norethindrone acetate 66.7 µM 0.372275305367125 0.354293161075139 no 1153 0.354843941447042 1645 541197 SGTC_2995 9067767 71.4286 µM 0.371638886739097 0.354539549126627 no 1154 0.35508086605451 1687 11673567 SGTC_689 0833-0039 98 µM 0.371134760227545 0.354734763798269 no 1155 0.355268581010911 1770 5374726 SGTC_1157 4092-0394 27.6 µM 0.371051327647605 0.354767075368959 no 1156 0.355299651091673 1750 3659885 SGTC_664 1222-0054 14.9 µM 0.37093749556098 0.35481116167335 no 1157 0.355342043422868 1666 6813991 SGTC_1291 0993-0025 5.79 µM 0.370224166993305 0.355087472670088 no 1158 0.355607735626808 1763 4353356 SGTC_99 0109-0120 622.8 µM 0.368944865476557 0.355583206656576 no 1159 0.356084410460724 1766 759414 SGTC_513 4245-1575 41.7 µM 0.368738100044722 0.355663351976062 no 1160 0.356161473549161 1767 719745 SGTC_1552 6-methylflavone 10.6 µM 0.367839649438295 0.356011678699082 no 1161 0.356496401293975 1784 689013 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.366448249119141 0.356551357782463 no 1162 0.35701531105652 1783 5357218 A potent inhibitor of glutathione S-transferases. SGTC_84 0443-0269 128.823 µM 0.365939877372453 0.356748610434022 no 1163 0.35720496961147 1682 6150058 SGTC_1976 st070609 63.5 µM 0.365022634919463 0.357104605364439 no 1164 0.357547255047574 1659 682556 SGTC_1349 flufenamic acid 69 µM 0.363853499753002 0.357558543827667 no 1165 0.357983704883585 1666 3371 A non-steroidal anti-inflammatory. SGTC_3222 9128301 49.47 µM 0.362545524109518 0.358066628591969 no 1166 0.358472205323896 1661 4911358 SGTC_2078 5212016 200 µM 0.358770348344414 0.359534507988973 no 1167 0.359883448242476 1790 1899708 SGTC_604 1000-0114 314 µM 0.357644778618705 0.359972559198548 no 1168 0.360304581664677 1793 1572745 SGTC_179 1273-0063 6.77 µM 0.356445390072943 0.360439541805423 no 1169 0.360753521094775 1639 3108139 SGTC_1461 k072-0203 53.8 µM 0.35564169252331 0.360752578474923 no 1170 0.361054458100037 1656 5418714 SGTC_2866 9034245 58.44 µM 0.355394265097561 0.36084896916867 no 1171 0.361147122304826 1815 6462273 SGTC_933 2914-0560 114 µM 0.355255508794073 0.360903028550321 no 1172 0.361199091584089 1858 463887 SGTC_2635 hydroquinidine 100 µM 0.355248094049505 0.360905917409068 no 1173 0.36120186874756 1684 442912 An experimental heart treatment. SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.355097286973353 0.360964675078145 no 1174 0.361258354533176 1661 688803 SGTC_1270 0831-1170 17.3 µM 0.354869022274883 0.361053618138792 no 1175 0.36134385833653 1682 6764716 SGTC_541 4513-1321 94 µM 0.354742933151781 0.361102751833069 no 1176 0.361391091998155 1649 747515 SGTC_2447 5741742 33.78 µM 0.353888176193056 0.361435889065298 no 1177 0.361711344212046 1771 1776504 SGTC_2099 5377090 177.372 µM 0.353327571519422 0.361654438999316 no 1178 0.361921438866917 1671 2243829 SGTC_1317 1273-0028 910 nM 0.353296124392576 0.361666699898518 no 1179 0.36193322536279 1678 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2887 9044784 58.44 µM 0.353278455518097 0.36167358886646 no 1180 0.361939847777741 1690 6465546 SGTC_1719 st032227 49.2 µM 0.352613860476571 0.361932742265948 no 1181 0.362188972546549 1629 3125804 SGTC_375 3970-0961 9.27 µM 0.352345680434175 0.362037334817024 no 1182 0.362289516906717 1724 2898222 SGTC_453 enantio-paf c16 10 µM 0.351874994967411 0.362220931153958 no 1183 0.362466006283416 1696 13871343 A lipid and platelet activating factor SGTC_1134 3477-0009 42.5 µM 0.351148984166269 0.362504182251172 no 1184 0.362738290381774 1868 3973534 SGTC_2495 cafestol 54.53 µM 0.349745226784721 0.363052067665158 no 1185 0.363264954275569 1750 16667697 An anti-infammatory. SGTC_686 1319-0111 510 µM 0.349013233656775 0.363337875312817 no 1186 0.363539687257125 1801 4562600 SGTC_1562 morin hydrate 59.1 µM 0.347793012568881 0.363814481284267 no 1187 0.36399781881406 1732 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_981 1488-1094 54.9 µM 0.34776341809521 0.363826043206329 no 1188 0.364008932466108 1681 3449522 SGTC_1127 asiatic acid 681.4 nM 0.347710563596885 0.363846692626403 no 1189 0.364028781270694 1652 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_2997 9067075 71.4286 µM 0.346375571910898 0.364368383832079 no 1190 0.364530240496254 1765 27209819 SGTC_1975 st070967 30.8 µM 0.344941216633841 0.364929184693808 no 1191 0.365069281839459 1832 261391 SGTC_572 0960-0087 17.7 µM 0.344287086992237 0.365185030815031 no 1192 0.365315197234661 1639 6796365 SGTC_2350 9023895 38.85 µM 0.342964125366143 0.365702656843427 no 1193 0.365812724461464 1783 2997209 SGTC_1073 triclabendazole 3.09 µM 0.342788610297841 0.365771347807941 no 1194 0.365878747533837 1734 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2094 5332512 191.667 µM 0.342320923496559 0.365954406419783 no 1195 0.366054695520044 1803 755774 SGTC_1956 st077085 54 µM 0.341759640414891 0.366174140107083 no 1196 0.366265892458995 1686 24208685 SGTC_2956 9076196 2.52 µM 0.340576420003674 0.366637496400778 no 1197 0.366711241690794 1742 16423868 SGTC_3105 9121040 49.47 µM 0.340367541180969 0.366719314825407 no 1198 0.366789879700654 1785 41448907 SGTC_2857 9024691 58.44 µM 0.338822624587328 0.36732465083558 no 1199 0.36737167820297 1710 16478292 SGTC_759 3486-0358 89.3 µM 0.33873874937019 0.367357524646191 no 1200 0.367403273411292 1886 875103 SGTC_1454 4239-0054 42.6 µM 0.336950174482846 0.36805876457725 no 1201 0.368077230429656 1826 1340767 SGTC_1687 st020778 55.3625 µM 0.33620753053712 0.368350059617896 no 1202 0.368357187284828 1749 4259299 SGTC_1359 1582-0056 520 nM 0.335072793328628 0.368795295653639 no 1203 0.368785087757809 1768 3661189 SGTC_2166 5933061 31.504 µM 0.334462564464152 0.369034803598576 no 1204 0.36901526757747 1835 2877375 SGTC_2896 9052656 71.43 µM 0.333564545760731 0.369387358281218 no 1205 0.369354087852754 1736 6469436 SGTC_1143 3454-2408 5.08 µM 0.33261769479447 0.369759203096771 no 1206 0.369711442355008 1729 X1143 SGTC_2840 9008771 71.43 µM 0.332539680681584 0.369789846030271 no 1207 0.369740890971169 1886 2992978 SGTC_2198 6589944 200 µM 0.332134378641126 0.369949056726822 no 1208 0.369893895891228 1776 5290268 SGTC_2 0422-0095 29 µM 0.331946559141023 0.37002284351947 no 1209 0.369964806313674 1716 6790840 SGTC_1965 Pectolinarigenin 58.4 µM 0.331796602454649 0.370081758957464 no 1210 0.370021424972255 1704 5320438 An anti-inflammatory. SGTC_800 3448-7362 155 µM 0.331103836800741 0.370353974385183 no 1211 0.370283026799699 1774 15991913 SGTC_2797 7859098 81.82 µM 0.331036654648477 0.370380376405225 no 1212 0.37030839928507 1700 972681 SGTC_2105 5350118 200 µM 0.329897618474785 0.370828100873951 no 1213 0.370738661522193 1701 2133313 SGTC_1191 1487-1166 10.6 µM 0.329302740799541 0.371062000865679 no 1214 0.370963436344431 1806 3955771 SGTC_897 1000-0139 31.4 µM 0.329057606760382 0.371158399000296 no 1215 0.371056073177761 1850 6151020 SGTC_3125 9127534 49.47 µM 0.328629751625384 0.371326670956164 no 1216 0.371217778720834 1764 1639235 SGTC_250 brefeldin a 552.239 µM 0.328059375089774 0.37155103367281 no 1217 0.371433384816159 1727 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_3149 9097855 49.47 µM 0.328041357029029 0.37155812194984 no 1218 0.371440196419795 1870 25236625 YMR079W SEC14 SGTC_708 3448-5400 146 µM 0.327386480350323 0.371815778955225 no 1219 0.371687795341477 1794 3462195 SGTC_3305 9127027 53.8275 µM 0.326749423787674 0.372066479855082 no 1220 0.371928707691877 1755 41905295 SGTC_3349 9149703 23.001 µM 0.326258717871333 0.372259624366941 no 1221 0.372114309581909 1709 4910494 SGTC_1100 amiodarone 5.07 µM 0.325056864857496 0.372732815900317 no 1222 0.372569017255755 1901 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_3220 9131269 49.47 µM 0.324032952394765 0.373136100577135 no 1223 0.372956543295232 1741 17722206 SGTC_3057 9095946 49.47 µM 0.321706188957394 0.374053050766324 no 1224 0.37383764440211 1759 24540043 SGTC_1251 0490-5699 265 µM 0.320496397941104 0.374530097338933 no 1225 0.374296030254379 1892 3883818 SGTC_760 0568-0725 82.9 µM 0.319748501564114 0.374825105081705 no 1226 0.374579494696136 1878 3916171 SGTC_2675 theaflavin digallate 100 µM 0.319411882633648 0.374957908345202 no 1227 0.374707100675928 1764 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2404 5161160 200 µM 0.319354566501162 0.374980522245293 no 1228 0.374728829523805 1782 2831543 SGTC_2879 9041815 71.43 µM 0.319237118587352 0.375026862293527 no 1229 0.374773355889326 1777 4942971 SGTC_2839 9003951 25.97 µM 0.318708951809176 0.375235277165208 no 1230 0.374973612912898 1816 2990634 SGTC_2955 9076254 12.21 µM 0.318212129918863 0.375431356579184 no 1231 0.37516201614015 1895 16459619 SGTC_1299 1079-1439 3.74 µM 0.316061891204277 0.376280356234848 no 1232 0.375977765782293 1711 323161 SGTC_1431 4049-0260 9.09 µM 0.315740608156307 0.376407263079382 no 1233 0.376099700666608 1814 3854841 SGTC_655 k060-0012 42 µM 0.315583570885406 0.376469297683549 no 1234 0.376159304706782 1742 5994525 SGTC_2349 9023730 187.07 µM 0.315340770568058 0.376565217637147 no 1235 0.376251466222207 1850 4126287 SGTC_1425 4048-4433 7.33 µM 0.314583009681136 0.37686462533215 no 1236 0.376539140491999 1848 23734946 SGTC_430 0958-0115 16.4 µM 0.313437502171916 0.377317380659922 no 1237 0.376974147984194 1744 6833180 SGTC_2930 9013230 14.89 µM 0.313136334429692 0.377436443526073 no 1238 0.377088542656769 1860 2995857 SGTC_170 4197-0004 226 µM 0.311056406569868 0.378259034237297 no 1239 0.377878870397549 1829 218692 SGTC_1411 3909-8223 150 µM 0.310071258164151 0.378648843513479 no 1240 0.378253384245256 1869 X1411 SGTC_1015 4130-4525 82 µM 0.309819857354045 0.378748339048949 no 1241 0.378348975071777 1711 1363237 SGTC_2338 7999974 200 µM 0.308233980748838 0.37937615782936 no 1242 0.378952148732791 1940 315925 SGTC_2309 7664088 163.95 µM 0.307418129233739 0.379699262203032 no 1243 0.379262565365999 1924 704922 SGTC_2886 9058944 51.95 µM 0.307303705676307 0.379744584465694 no 1244 0.379306107674684 1760 4949929 SGTC_955 1216-0110 33 µM 0.306855150221917 0.379922269646362 no 1245 0.379476814035058 1698 3619719 SGTC_2656 pseudo-anisatin 100 µM 0.304511657640913 0.38085100308974 no 1246 0.380369056341076 1791 6708809 A neurotoxin. SGTC_2643 anethole 100 µM 0.303742147736703 0.381156112346246 no 1247 0.380662172413474 1796 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_898 1000-0849 28.3 µM 0.302595808990776 0.38161077052435 no 1248 0.381098954383324 1887 6751807 SGTC_2533 agelasine 13.65 µM 0.302346145223213 0.381709813270229 no 1249 0.381194102252709 1944 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2224 6650123 117.647 µM 0.300709265203777 0.382359362540007 no 1250 0.381818101504011 1791 2908370 SGTC_285 1486-1325 46 µM 0.300427353224775 0.382471264768396 no 1251 0.381925600950708 1858 22310230 SGTC_1555 citronellol 128 µM 0.300414565694802 0.382476340887274 no 1252 0.381930477342529 1914 8842 A terpine precursor. SGTC_2909 7941780 10.49 µM 0.300277102709284 0.382530909264681 no 1253 0.381982898608108 1930 1243215 SGTC_119 0121-0043 24.815 µM 0.299821947613492 0.382711607818776 no 1254 0.3821564866351 1853 1092378 SGTC_1934 st074720 32.6 µM 0.299718859520205 0.382752537788532 no 1255 0.382195805884921 1690 17250992 SGTC_1394 3474-0001 65.7 µM 0.299541338594056 0.382823023547489 no 1256 0.382263517712014 1745 5017666 YIL048W NEO1 SGTC_2101 5377231 179.231 µM 0.29868546683615 0.383162907034045 no 1257 0.382590023466899 1868 2844213 SGTC_2848 9016370 25.97 µM 0.298153231816448 0.383374313398261 no 1258 0.382793107441232 1944 7894410 SGTC_201 4262-0159 12.803 µM 0.297728237252416 0.383543148268761 no 1259 0.382955295010041 1908 1341029 SGTC_1245 0418-0076 17.2 µM 0.296988187290637 0.383837195946196 no 1260 0.383237763835638 1799 6790114 SGTC_478 N-arachidonylglycine 10 µM 0.296347087028432 0.384091981539221 no 1261 0.383482514860233 1883 5283389 SGTC_365 0121-0052 13.6 µM 0.295382005237392 0.384475618075741 no 1262 0.383851039056821 1830 3101739 SGTC_1164 k060-0068 93.7 µM 0.295163138286537 0.384562637193224 no 1263 0.3839346297789 1795 5963676 SGTC_1310 1188-0297 994 nM 0.294742494466468 0.384729896927141 no 1264 0.384095299256493 1832 1588352 SGTC_2426 5582046 32.21 µM 0.294342604849984 0.384888924105496 no 1265 0.384248059912111 1831 2251934 SGTC_367 0335-0881 7.1 µM 0.294178604974782 0.384954148798162 no 1266 0.384310714222547 1867 23828853 SGTC_1839 st053978 48 µM 0.293805326215899 0.385102618316671 no 1267 0.384453332447844 1873 3788398 SGTC_1273 0849-0096 14.1 µM 0.293624759940728 0.385174443579475 no 1268 0.384522326830337 1763 5286025 SGTC_2489 cantharidin 73.42 µM 0.292096644678794 0.385782451477969 no 1269 0.38510636601783 1721 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1263 0774-1208 64.8 µM 0.290120826240801 0.386569007884265 no 1270 0.385861901813328 1933 906585 SGTC_2823 7987624 58.44 µM 0.288759536054705 0.387111197340025 no 1271 0.386382699569311 1815 2239440 SGTC_3205 9113483 49.47 µM 0.287003888039013 0.387810781115804 no 1272 0.387054671598484 1903 17018033 SGTC_98 0074-0023 107.663 µM 0.284654232214092 0.388747632555327 no 1273 0.387954528964606 1752 3563821 SGTC_423 5-fluorouracil 457 µM 0.282708327155703 0.389523991428754 no 1274 0.388700216203118 1688 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2988 9073640 71.4286 µM 0.281757169275166 0.389903636139275 no 1275 0.389064857394973 1843 9102229 SGTC_210 3551-0445 56.827 µM 0.280202596841404 0.390524353467062 no 1276 0.389661037225902 1865 2865180 YOR207C RET1 SGTC_1936 st074407 74.3 µM 0.280165204063012 0.390539287283418 no 1277 0.389675380592142 1752 809813 SGTC_1289 0976-0073 69.1 µM 0.279733759193746 0.390711608124209 no 1278 0.389840887898424 1877 3391136 SGTC_2143 5623677 140.463 µM 0.276321692843519 0.392075154894618 no 1279 0.391150497903136 1911 5375313 SGTC_2605 digitonin 300 nM 0.276206194112836 0.392121334370083 no 1280 0.391194850006016 1983 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_52 0329-0193 875 nM 0.275890958649482 0.39224738165421 no 1281 0.391315909234447 1906 3739292 SGTC_3026 9090633 49.47 µM 0.275505946384794 0.392401344613983 no 1282 0.391463778986537 1783 25236842 SGTC_1974 st069448 26.9 µM 0.273769654091449 0.393095881289024 no 1283 0.392130822741085 1941 6323587 YNR016C ACC1 SGTC_2411 st077133 39.94 µM 0.273390387927683 0.393247637448429 no 1284 0.392276570388661 1965 1403142 YNL221C POP1 SGTC_1753 st043925 64 µM 0.272962498611444 0.393418868713871 no 1285 0.392441021499976 1947 670181 SGTC_1479 0549-0158 134 µM 0.272444886582452 0.393626032455888 no 1286 0.392639981497557 1814 5440202 SGTC_1796 st049173 110.4 µM 0.272340627427878 0.393667763718591 no 1287 0.392680060085685 1926 94134 SGTC_2765 myclobutanil 7.74 µM 0.272296971004705 0.393685238207965 no 1288 0.392696842526089 1825 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_363 0455-0021 3.06 µM 0.271994044773795 0.393806497307735 no 1289 0.392813299186255 1807 4597466 SGTC_2602 kawain 100 µM 0.269613301250957 0.394759848691011 no 1290 0.393728883133771 1919 5369129 SGTC_2685 mycophenolic acid 18.85 µM 0.269008108180264 0.395002294584815 no 1291 0.393961721581812 1901 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1929 genistein trimethyl ether 50.5 µM 0.268339426166105 0.395270222010336 no 1292 0.394219030475697 1997 136420 SGTC_678 1218-2179 85.9 µM 0.267572967507534 0.395577387471089 no 1293 0.39451402061919 1861 6820081 YOR116C RPO31 SGTC_2620 irigenin 100 µM 0.266399862261332 0.396047645923719 no 1294 0.394965635647327 1912 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_120 rhodamine 6G 52.259 µM 0.266069426084851 0.396180134021726 no 1295 0.39509287049185 1838 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1438 4092-1045 4 µM 0.265922687219353 0.396238972688425 no 1296 0.395149376055036 1827 1351342 SGTC_2773 thioridazine 9.09 µM 0.265482535796881 0.396415476728197 no 1297 0.395318880869461 1932 5452 An antipsychotic. SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.263642129595104 0.397153723086167 no 1298 0.396027845975569 1938 165506 SGTC_2932 9016711 44.54 µM 0.263522393485594 0.397201765906734 no 1299 0.39607398291396 1980 7117328 SGTC_2106 5357045 167.29 µM 0.263080390515533 0.397379128325527 no 1300 0.396244308914229 1904 668842 SGTC_2911 7942208 15.64 µM 0.262985104701329 0.397417366421493 no 1301 0.3962810299326 1816 1243384 SGTC_2259 7964009 200 µM 0.262271230641592 0.397703874659281 no 1302 0.396556170254685 1889 313134 SGTC_260 nsc-65238 3.989 µM 0.261897725351241 0.397853800331173 no 1303 0.396700146668515 1905 3246252 SGTC_2247 cerulenin 830 nM 0.261778286102149 0.397901746637602 no 1304 0.396746190314018 1929 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1432 4049-0298 68.4 µM 0.261286548056669 0.398099160488935 no 1305 0.396935769726815 1983 741646 SGTC_3032 9089427 49.47 µM 0.258703085392462 0.399136748527892 no 1306 0.397932169395751 1836 17173707 SGTC_2127 5253358 187.912 µM 0.258702947997674 0.399136803728357 no 1307 0.397932222404463 1795 20612 SGTC_245 methotrexate 289.6 µM 0.257275483347815 0.399710418230408 no 1308 0.398483058527409 1910 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2275 7947463 200 µM 0.257228632610895 0.399729248476104 no 1309 0.398501140923873 1976 1225414 SGTC_127 0180-0333 59.125 µM 0.25690799296417 0.399858126203189 no 1310 0.398624900069249 1958 771601 SGTC_2918 7977171 22.06 µM 0.256533202974435 0.400008782917776 no 1311 0.398769572859049 1834 2236483 SGTC_1282 0886-0010 32.4 µM 0.255804328997793 0.400301815623223 no 1312 0.399050965522657 1981 2836211 YNL267W PIK1 SGTC_2314 7727897 200 µM 0.254650598640166 0.400765770069344 no 1313 0.399496487530791 1791 900724 SGTC_2376 9072922 81.32 µM 0.254277148744518 0.4009159770757 no 1314 0.399640726203549 1903 17087968 SGTC_1204 4049-0315 18.3 µM 0.253307266586558 0.401306146230253 no 1315 0.40001539063102 1952 588402 SGTC_2758 dehydroepiandrosterone 69.35 µM 0.253039619484745 0.401413834021332 no 1316 0.400118798638038 1861 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1802 st050112 57.9 µM 0.252895285959599 0.401471909712698 no 1317 0.400174566177397 1942 4662563 SGTC_2168 5727979 200 µM 0.252411372823981 0.401666638422373 no 1318 0.400361555220851 1883 695210 SGTC_683 panaxydol 45 µM 0.251759092861847 0.401929157294154 no 1319 0.400613639085261 1950 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_674 0498-0004 451 µM 0.25148388172348 0.402039933011612 no 1320 0.400720011188653 1818 4231473 SGTC_108 0509-0257 621.132 µM 0.251174916196604 0.402164304643199 no 1321 0.400839438502841 1946 536624 SGTC_1092 toremifene 6.32 µM 0.25071934398539 0.402347709705997 no 1322 0.401015551965854 1924 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_446 go6976 132 µM 0.250672011492382 0.402366766137904 no 1323 0.401033850744568 1999 3501 A protein kinase C inhibitor. SGTC_460 trequinsin 123 µM 0.250386888910103 0.402481563626769 no 1324 0.401144083949 1941 5537 A vasodilator. SGTC_2277 7947813 106.88 µM 0.248985775968529 0.403045808797339 no 1325 0.401685892068585 1960 1246798 SGTC_1667 st014849 34.6 µM 0.24835802434504 0.403298677568601 no 1326 0.401928703995088 1909 5348460 SGTC_2477 5967686 25.23 µM 0.248272020445019 0.403333324518713 no 1327 0.401961972925329 1823 776118 SGTC_3094 9117742 49.47 µM 0.24793273338606 0.403470014809807 no 1328 0.402093226429325 1913 17149698 SGTC_591 4299-0174 154 µM 0.247677025917626 0.403573040763273 no 1329 0.402192154390931 1902 5509088 SGTC_1464 k208-0027 110 µM 0.247590136131559 0.4036080506623 no 1330 0.402225771689069 1964 X1464 SGTC_1550 gossypolone 36.6 µM 0.247259411698135 0.403741314227745 no 1331 0.402353734214931 1956 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_884 0851-0618 334 µM 0.245249076024634 0.404551607652411 no 1332 0.403131789608151 1987 9642473 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.245071925213214 0.40462303040661 no 1333 0.40320037030045 1873 16486 A toxic proline analog. SGTC_431 k089-0097 107 µM 0.244047245352676 0.405036217855105 no 1334 0.403597114699365 1906 5499420 SGTC_3227 9130768 49.47 µM 0.243830497735509 0.405123631804196 no 1335 0.403681049641517 1921 17720899 SGTC_1200 1643-0193 18.4 µM 0.242108502267614 0.405818277527229 no 1336 0.404348045151791 1983 5403974 SGTC_908 3448-7491 47.7 µM 0.240736014847579 0.406372145742902 no 1337 0.404879861940036 1843 1203031 SGTC_3318 9139014 38.6185 µM 0.240522887942487 0.40645817008476 no 1338 0.404962460974026 1871 16643984 SGTC_2294 7971431 200 µM 0.239728206731147 0.406778966769029 no 1339 0.40527048332393 1944 5741572 SGTC_2066 5222451 176 µM 0.238905800968578 0.407111021166184 no 1340 0.405589313637143 1903 2281147 SGTC_1501 4491-0275 38.4 µM 0.237883575158205 0.40752384792687 no 1341 0.405985697506158 2003 5104718 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.237571859006784 0.407649755218147 no 1342 0.406106589463463 1846 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_2972 9093619 59.92 µM 0.236842880225143 0.407944238982744 no 1343 0.406389342089734 1793 25236256 SGTC_1471 k673-0312 37 µM 0.236377847962932 0.408132124104895 no 1344 0.406569741981988 1990 24099884 SGTC_695 3505-6186 243 µM 0.234887522415373 0.408734396492964 no 1345 0.407148017171385 1923 1819379 SGTC_272 doxorubicin 8.13 µM 0.234869508656796 0.408741677559062 no 1346 0.407155008099603 1997 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_707 0865-0008 204 µM 0.234349296579889 0.408951958111982 no 1347 0.407356909051273 1933 723043 SGTC_1630 st005209 31.3 µM 0.231833605922157 0.409969221423519 no 1348 0.408333627142741 2054 3367314 SGTC_3324 9138759 60.749 µM 0.231688930470727 0.410027741960456 no 1349 0.408389814838205 1928 45595710 SGTC_3051 9093778 49.47 µM 0.230375709085722 0.410559025304941 no 1350 0.4088999174487 1979 17217378 SGTC_2808 7946468 45.46 µM 0.228905659434203 0.411153950573318 no 1351 0.40947112087836 1921 2970879 SGTC_2455 5377712 9.75 µM 0.227866597646487 0.411574579548919 no 1352 0.409874975420967 1810 2243908 SGTC_1364 1653-0028 37.6 µM 0.227706803417128 0.411639275861056 no 1353 0.409937091507411 1907 5718652 SGTC_402 epigallocatechin gallate 10 µM 0.226835461828045 0.411992100456063 no 1354 0.410275843899352 1868 65064 An antioxidant. SGTC_1768 st044301 37.178 µM 0.225733907895586 0.412438244692473 no 1355 0.410704191992727 1875 3931349 SGTC_1758 st042942 75.2445 µM 0.225546990073791 0.412513960183499 no 1356 0.410776887073967 2031 669317 SGTC_1353 1498-1206 8.11 µM 0.225004552454586 0.41273370581283 no 1357 0.41098786636033 1903 6756808 SGTC_2031 5180455 200 µM 0.223868639466055 0.4131939613867 no 1358 0.411429759251341 1917 29949 SGTC_3343 9148379 18.9835 µM 0.222538779725005 0.413732952979685 no 1359 0.411947244079212 2022 1955036 SGTC_647 0140-0236 81 µM 0.221772131557596 0.414043749099872 no 1360 0.41224563752506 1947 990837 SGTC_3265 9137266 49.47 µM 0.220265896395642 0.414654527481836 no 1361 0.412832039325454 2072 17224265 SGTC_1197 1601-0112 267 µM 0.220056408471002 0.414739491220876 no 1362 0.412913611817454 1855 7350313 SGTC_3111 9122088 49.47 µM 0.219786588258513 0.414848930298402 no 1363 0.413018682636374 2017 16876704 SGTC_499 genistein 192 µM 0.218645886429107 0.415311671889302 no 1364 0.413462952654989 1986 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_482 fipronil 114 µM 0.218011247866185 0.41556917277483 no 1365 0.413710173838021 2020 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_259 usnic acid 108.925 µM 0.217509458675414 0.415772796480366 no 1366 0.413905668243758 1989 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2283 7944793 200 µM 0.217346514929089 0.415838923157238 no 1367 0.413969154854404 1855 2970533 SGTC_718 1130-0073 349 µM 0.215639167213498 0.416531950827414 no 1368 0.414634511481184 1981 6740020 SGTC_1125 tnp00248 1.32998 µM 0.2131620805805 0.417537883278917 no 1369 0.415600271922368 2054 24207736 SGTC_300 r073-0011 5.04 µM 0.211658692415568 0.418148665370519 no 1370 0.416186658292633 2071 2735780 SGTC_979 1426-2828 121 µM 0.210501027796959 0.418619124864091 no 1371 0.416638324783183 1994 747872 SGTC_2402 5553605 200 µM 0.210407543802685 0.418657120604518 no 1372 0.416674802668698 1991 6758546 SGTC_1744 st037937 38.9 µM 0.207878390639101 0.419685359338061 no 1373 0.417661961183622 1987 1016152 SGTC_1991 st073000 8.92 µM 0.207451315582916 0.419859042976535 no 1374 0.417828705047754 2013 4301969 YIL048W NEO1 SGTC_2366 9070441 60.58 µM 0.206720407316157 0.42015632624428 no 1375 0.418114109450153 1915 6837235 SGTC_1187 1391-0724 117 µM 0.20418072381051 0.421189648134287 no 1376 0.419106137110308 1944 6997986 SGTC_3128 9127691 49.47 µM 0.203868962131513 0.421316532282643 no 1377 0.419227950154072 1961 41316314 SGTC_2300 7976697 71.57 µM 0.20375792614424 0.421361724886773 no 1378 0.419271336546991 1893 2236109 SGTC_878 0828-0289 13.7 µM 0.203117684812875 0.421622328819157 no 1379 0.41952152467968 1903 745350 YLR208W SEC13 SGTC_1043 0916-0009 19.3 µM 0.202081502187648 0.422044169455474 no 1380 0.419926504327162 2114 3101130 SGTC_1902 st060212 70.5 µM 0.200141103677176 0.422834365948424 no 1381 0.420685113777596 2067 688944 SGTC_168 3970-0862 530.542 µM 0.200091024268023 0.422854764117816 no 1382 0.420704696509955 1966 3135186 SGTC_1636 st007707 68.9 µM 0.199779494624369 0.422981659923573 no 1383 0.420826519477701 2040 403051 SGTC_2646 retinol 96.75 µM 0.199771081265304 0.422985087059776 no 1384 0.420829809608075 1989 445354 A vitamin A analog and teratogen. SGTC_1229 0139-0193 12.2 µM 0.199632306919616 0.423041616877874 no 1385 0.420884079537323 2082 3090752 SGTC_506 n9-isopropylolomoucine 153 µM 0.199357170319724 0.423153698631009 no 1386 0.420991680553275 2095 6610355 SGTC_1000 4048-0884 8.67 µM 0.199286796713995 0.423182367561395 no 1387 0.421019203363244 1968 13040088 SGTC_1397 3532-0190 20.1 µM 0.199088814502808 0.423263024104153 no 1388 0.421096635411763 1965 5322280 SGTC_1786 berberine 21.6 µM 0.198725263702747 0.423411140483289 no 1389 0.421238830289643 1944 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1815 st051655 58.2 µM 0.198465814247465 0.423516850938292 no 1390 0.421340314505374 2077 5984156 SGTC_122 0236-0016 402.397 µM 0.198170737663559 0.423637084051856 no 1391 0.421455740700576 1981 6808838 SGTC_2141 5621638 7.665 µM 0.197659282789955 0.423845500385532 no 1392 0.421655824372471 2048 2856238 SGTC_2691 st077356 60.2 µM 0.197166432286219 0.424046355650198 no 1393 0.4218486490615 2009 2839272 SGTC_3020 9089140 49.47 µM 0.196869551523565 0.424167355341846 no 1394 0.421964810856566 1933 17217859 SGTC_3152 9099253 49.47 µM 0.194527626762007 0.425122103325432 no 1395 0.422881382922662 2019 25236131 SGTC_415 dibenzyl ketone 100 µM 0.194228102677006 0.425244244098417 no 1396 0.422998639548695 2057 7593 SGTC_2228 7354201 200 µM 0.193937753500952 0.425362650350536 no 1397 0.423112310925506 2016 753451 SGTC_1171 0368-0077 21.4 µM 0.193738162409063 0.425444048780298 no 1398 0.423190454327144 1936 3239779 SGTC_2676 harmalol 100 µM 0.190875401551804 0.426611905007857 no 1399 0.42431160627617 2043 5459187 A monoamine oxidase inhibitor SGTC_1738 st035555 74 µM 0.190140826620784 0.426911677225788 no 1400 0.424599389292639 1972 5331140 SGTC_316 k060-0003 58.6 µM 0.1893928402657 0.427216965883103 no 1401 0.424892467781943 2042 6152314 SGTC_1304 1165-0502 251 µM 0.189381252635428 0.427221695687197 no 1402 0.424897008412599 1999 767425 SGTC_503 tyrphostin 8 294 µM 0.187612940106636 0.427943602401157 no 1403 0.425590040819097 2077 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1163 k060-0048 49.9 µM 0.187474978409924 0.427999934904057 no 1404 0.425644120102679 2022 6809982 SGTC_1983 st071813 46.9 µM 0.187133338997414 0.428139439380689 no 1405 0.425778044557319 1962 11838595 SGTC_1435 4092-0789 56.7 µM 0.186791300900201 0.428279115653168 no 1406 0.425912133875806 2073 2248285 SGTC_3320 9137005 35.139 µM 0.186396283726864 0.428440437888395 no 1407 0.426067003260088 1929 4908713 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.18554221435413 0.428789274657503 no 1408 0.426401886381573 2094 5024745 SGTC_2520 obtusaquinone 4.71 µM 0.183693889731999 0.429544395960152 no 1409 0.427126801315047 2076 5967872 SGTC_2327 6189656 200 µM 0.181884786894875 0.430283743188172 no 1410 0.427836571826981 2056 5349088 SGTC_2623 humulene 100 µM 0.181307642881614 0.430519662950533 no 1411 0.428063053649023 1948 6187145 An anti-inflammatory. SGTC_663 1486-0733 13.9 µM 0.181284165441096 0.430529260373997 no 1412 0.428072267126419 1985 722445 YPR165W RHO1 SGTC_3139 9095020 49.47 µM 0.181176084621865 0.430573443632135 no 1413 0.42811468282574 2098 25236292 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.178411931287666 0.431703718734269 no 1414 0.429199739907927 2075 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_287 k060-0039 29.6 µM 0.178275885207451 0.431759363124833 no 1415 0.429253158125706 2095 5861974 SGTC_1079 idarubicin 2.36 µM 0.178134081552107 0.431817363870135 no 1416 0.429308838422695 2120 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2064 5220758 200 µM 0.177522726805874 0.4320674379248 no 1417 0.429548907660151 2002 788518 SGTC_2390 9097792 176.6 µM 0.176369319090004 0.432539312257432 no 1418 0.430001903316324 1912 4497149 SGTC_2452 5863136 48.41 µM 0.176246918566011 0.432589393588271 no 1419 0.430049980986935 2032 2184096 SGTC_1679 SEC14.276 6.7 µM 0.175246378045706 0.432998814732095 no 1420 0.430443021871109 2107 1005053 YMR079W SEC14 SGTC_2904 7225135 42.03 µM 0.174673257611523 0.433233368022586 no 1421 0.430668191012892 2115 4446116 SGTC_2045 5106652 78.05 µM 0.173512472873842 0.433708498753952 no 1422 0.431124312321996 2084 673349 SGTC_1058 3448-5425 97.3 µM 0.172409565921962 0.434160027808597 no 1423 0.431557776135298 2101 7279705 SGTC_2729 fluphenazine 10.66 µM 0.170892996723384 0.434781049971214 no 1424 0.432153951732073 2065 3372 An atypical antipsychotic. SGTC_3082 9117008 49.47 µM 0.170653954614564 0.434878950399825 no 1425 0.432247935247438 1974 41448529 SGTC_559 1550-0661 158 µM 0.16975970182147 0.435245229732727 no 1426 0.432599560067044 2025 5830875 SGTC_2041 5107442 45.335 µM 0.16950732905079 0.435348609821407 no 1427 0.432698804015272 2089 793005 SGTC_3209 9113616 49.47 µM 0.169225343411293 0.435464125530336 no 1428 0.432809698053134 2170 16649353 SGTC_886 0866-0150 153 µM 0.168852029905644 0.435617062263866 no 1429 0.432956515944817 2128 271463 SGTC_495 decylubiquinone 155 µM 0.16804879864416 0.435946157625091 no 1430 0.433272444576505 1958 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2456 5770359 74.46 µM 0.166828700466456 0.436446134123027 no 1431 0.433752417717991 2090 3118787 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.166773362491155 0.4364688131437 no 1432 0.433774189387521 2019 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2570 licareol 100 µM 0.16635141030771 0.436641747588293 no 1433 0.433940205018018 1972 443158 SGTC_563 tetrahydrosecaminediol 614 µM 0.166207744601217 0.436700630838297 no 1434 0.433996732455255 2112 334274 A psychoactive constituent of the cannabis plant. SGTC_1573 oleylamine 1.06 µM 0.165339857140343 0.43705637553467 no 1435 0.434338244521899 1988 5356789 An amine of the fatty acid oleic acid. SGTC_2755 lomerizine 42.69 µM 0.1646578089914 0.437335980939216 no 1436 0.434606663576388 1993 3949 A calcium channel blocker. SGTC_211 3455-0679 143.504 µM 0.164480987560171 0.437408473938835 no 1437 0.434676256318529 2011 748649 SGTC_2587 piperic acid 92.2 µM 0.163748614711344 0.437708753469586 no 1438 0.43496452251648 1986 5370536 SGTC_94 0334-0113 514.748 µM 0.162793375136029 0.438100464275406 no 1439 0.435340562280858 1993 6795178 SGTC_2464 5717415 7.67 µM 0.161835865412471 0.43849316686504 no 1440 0.435717554401765 1946 5285744 SGTC_1350 1495-0454 146 µM 0.161241150168384 0.43873710740144 no 1441 0.435951735986441 2095 1069057 SGTC_1898 st060199 18.6 µM 0.160515962816029 0.439034596523001 no 1442 0.436237324076749 1962 688866 SGTC_2640 pentamidine 10.38 µM 0.160349419252342 0.439102921527835 no 1443 0.436302915769987 2148 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_812 4251-0442 148 µM 0.159964986973317 0.439260642967236 no 1444 0.436454327670646 2131 5723007 SGTC_526 4469-0568 170 µM 0.159423626115442 0.439482764006889 no 1445 0.436667563001542 1927 2901964 SGTC_162 k030-0015 37.8 µM 0.159195302356433 0.439576451248621 no 1446 0.436757502421252 2099 1809920 YMR134W ERG29 SGTC_2665 lovastatin 100 µM 0.159131995026591 0.439602428510092 no 1447 0.436782440503703 2026 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2518 prenyletin 46.28 µM 0.158975929291725 0.439666468972981 no 1448 0.436843919136498 2114 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1909 st060837 51.5 µM 0.158864200258436 0.439712317155946 no 1449 0.43688793324662 1998 678937 SGTC_2222 6885208 172.143 µM 0.157823404665738 0.440139448017592 no 1450 0.43729797776514 2063 609514 SGTC_828 2074-0507 139 µM 0.156301362808948 0.440764202272106 no 1451 0.437897741088109 2124 X828 SGTC_1731 st035964 63 µM 0.156228789132933 0.440793995367248 no 1452 0.437926342450317 1941 6739575 SGTC_386 1509-0011 3.07 µM 0.15620439374189 0.440804010288755 no 1453 0.437935956772472 2044 3107280 SGTC_1360 1598-0022 39.8 µM 0.155151722500458 0.441236194285344 no 1454 0.438350853585029 2077 761525 SGTC_1985 st071382 65.5 µM 0.155067406599393 0.4412708139991 no 1455 0.438384088548885 2141 6123237 SGTC_2809 7964133 12.99 µM 0.154857038289879 0.441357192196899 no 1456 0.438467011731546 2017 1253665 SGTC_2837 9008476 45.46 µM 0.154787624118369 0.441385694588016 no 1457 0.438494374069389 2055 2992805 SGTC_851 0394-0702 453 µM 0.154402284846511 0.441543925584459 no 1458 0.43864627610836 2150 762646 SGTC_763 3453-1109 128 µM 0.15425883690142 0.441602831675139 no 1459 0.438702826081204 2144 1560353 SGTC_2129 girgensonine 121.053 µM 0.153627390483602 0.44186214692974 no 1460 0.438951769415779 2047 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2335 9018011 154.17 µM 0.153479197764669 0.441923008649486 no 1461 0.439010196861504 2114 6458208 SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.152257079745123 0.442424976172799 no 1462 0.439492087783809 2118 140250 A respiratory chain inhibitor. SGTC_2413 inermin 26.06 µM 0.151826792007205 0.442601732762711 no 1463 0.439661775066075 2135 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2700 st077718 96.8 µM 0.151355055517663 0.442795529087716 no 1464 0.439847820720682 1992 904970 SGTC_1415 3966-0071 78.1 µM 0.150872995950178 0.442993580425482 no 1465 0.440037951362302 2131 2893185 SGTC_1142 3253-1408 9.78 µM 0.150714969194302 0.443058507891101 no 1466 0.44010028220763 2155 256655 SGTC_21 0849-0113 22.993 µM 0.149893944114488 0.443395861904452 no 1467 0.440424144817215 2050 1560156 SGTC_2156 5649887 115 µM 0.149516605692912 0.44355092165271 no 1468 0.440573003598673 2124 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_2291 7917025 104.35 µM 0.149415559857899 0.443592445904812 no 1469 0.44061286727882 2012 2964612 SGTC_1133 3473-0247 50 µM 0.148792274549236 0.443848595385985 no 1470 0.440858773398356 1896 711311 SGTC_2768 sulfasalazine 50.2 µM 0.147667436019106 0.444310925821644 no 1471 0.441302616065254 2142 5384001 An antioxidant and salicylic acid derivative. SGTC_2145 5634607 200 µM 0.147458368921338 0.444396864821441 no 1472 0.441385118623534 2025 308662 SGTC_739 1486-1183 203 µM 0.146694647514479 0.444710821886396 no 1473 0.441686521781966 2158 4346692 SGTC_232 clozapine 119 µM 0.146467110559925 0.44480436642102 no 1474 0.441776325928588 2101 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_111 0083-0039 52.457 µM 0.14599987895687 0.444996463368449 no 1475 0.441960741990901 2169 759313 SGTC_3260 9137109 49.47 µM 0.145622699837158 0.445151545688887 no 1476 0.442109623565437 2152 17478346 SGTC_320 4092-0846 5.34 µM 0.144905573538313 0.445446425045028 no 1477 0.442392712919124 2134 1359356 SGTC_2679 rapamycin 1 nM 0.14459591812741 0.44557376340433 no 1478 0.442514960113128 2072 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2708 st078559 56 µM 0.142227685347853 0.446547827056389 no 1479 0.44345008216621 2152 17250902 SGTC_1321 1326-2144 215 µM 0.141075783739744 0.447021725796692 no 1480 0.443905037039136 2150 3513030 SGTC_2379 9035213 200 µM 0.140785522185748 0.447141152978002 no 1481 0.444019690381967 2197 646551 SGTC_968 1309-0633 340 µM 0.139099624183828 0.447834904711892 no 1482 0.444685712598701 2165 3761976 SGTC_796 1234-0020 70.7 µM 0.139088008604201 0.447839685111356 no 1483 0.444690301933961 2160 46495034 SGTC_1882 5615643 20 µM 0.138327899192333 0.448152525078024 no 1484 0.444990638544523 2193 2253075 SGTC_1827 berberine 7.24 µM 0.136768547564937 0.448794411717407 no 1485 0.445606872692032 1936 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_226 1,3-diallylurea 8.28947 mM 0.135051491309774 0.449501370415898 no 1486 0.446285581515064 2122 74537 YKL182W FAS1 SGTC_1525 8-methoxypsoralen 92.5 µM 0.132961403308847 0.450362132557679 no 1487 0.447111952555258 2187 4114 Related to psoralen; DNA damaging agent. SGTC_934 2950-0684 338 µM 0.131881883849907 0.450806803395207 no 1488 0.447538859025043 2191 1121253 SGTC_1051 3253-3903 78 µM 0.131861459289467 0.450815217185949 no 1489 0.44754693670355 2163 5509239 SGTC_2515 chrysin 20.77 µM 0.131546104424381 0.450945128774347 no 1490 0.447671658681059 2135 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1180 1193-0155 285 µM 0.13123707835956 0.451072438288333 no 1491 0.447793882654958 2062 2921347 SGTC_2789 5281112 71.43 µM 0.130663393995359 0.451308792456569 no 1492 0.448020795687624 2035 765948 SGTC_1928 4'-methoxychalcone 40.3 µM 0.129670400633202 0.451717939915312 no 1493 0.448413600840697 2212 641818 SGTC_1829 berberine 14.4 µM 0.129094075548547 0.451955429246638 no 1494 0.448641604905298 2171 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_548 1436-0017 110 µM 0.129014083320743 0.451988393428513 no 1495 0.448673252541693 2180 9677137 SGTC_1070 indatraline 8.81 µM 0.128790252058181 0.452080634328572 no 1496 0.448761809510139 2057 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2589 lobaric acid 100 µM 0.128353639553902 0.452260569852805 no 1497 0.448934558941369 2043 73157 A novel microtubule depolymerizer. SGTC_1206 3978-0017 132 µM 0.128324350985347 0.45227264052713 no 1498 0.44894614755817 2087 3873677 SGTC_1065 prochlorperazine maleate 2.48 µM 0.125730739710765 0.453341717105844 no 1499 0.449972534088959 2183 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_765 1319-0117 244 µM 0.123684956686599 0.454185219999758 no 1500 0.450782361509184 2206 3487746 YGL099W LSG1 SGTC_2769 toremifene 3.73 µM 0.122919611789058 0.454500834960719 no 1501 0.451085377716871 2133 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.122859066551949 0.45452580399519 no 1502 0.451109350073952 2203 6708630 An antioxidant. SGTC_1230 0170-0365 3.77 µM 0.122298353185373 0.454757052367521 no 1503 0.451331368088628 2184 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_2301 7769476 200 µM 0.121708503543472 0.455000333617239 no 1504 0.451564939227608 2132 977820 SGTC_1981 st071826 47 µM 0.121667942494642 0.455017063489399 no 1505 0.451581001379215 2086 11838600 SGTC_1677 st019204 53.9 µM 0.121207887631305 0.455206823998399 no 1506 0.451763188377918 2005 3945625 SGTC_574 1315-0397 40 µM 0.120339171525618 0.455565174339393 no 1507 0.452107237586094 2182 6794277 SGTC_1967 st070177 51.4 µM 0.120296764758286 0.455582668300315 no 1508 0.452124033425753 2146 5729214 SGTC_1597 7-benzyloxygramine 47.5 µM 0.11664976403854 0.457087475284916 no 1509 0.453568800439456 2049 260807 SGTC_3104 9120930 49.47 µM 0.115747526417543 0.457459847814598 no 1510 0.453926319363113 2108 17014836 SGTC_1805 st050013 60.3 µM 0.115558295710081 0.457537952074882 no 1511 0.454001308301347 2161 4037144 SGTC_1167 k781-0610 148 µM 0.114477769102962 0.457983966681334 no 1512 0.454429534109401 2118 4525169 SGTC_110 0850-0284 111.64 µM 0.114191842686648 0.458101998896709 no 1513 0.454542859102011 2210 3906265 SGTC_2810 7959871 45.46 µM 0.114119069549003 0.458132040693977 no 1514 0.454571702831806 2158 2974535 SGTC_1800 st050079 29.0735 µM 0.114046742893936 0.458161898413799 no 1515 0.454600369834981 2163 3645560 SGTC_1208 2323-2347 50.3 µM 0.113421737661687 0.458419921422334 no 1516 0.454848103375046 2220 5412760 SGTC_2878 9043973 25.97 µM 0.113277855362058 0.458479323320187 no 1517 0.454905136542252 2181 6465167 SGTC_2023 5144124 124 µM 0.110876090957757 0.459471029171849 no 1518 0.455857302666851 2127 2830192 SGTC_340 k038-0059 454 µM 0.109840556363827 0.459898687059421 no 1519 0.456267913148165 2184 23733424 SGTC_1041 0206-0046 107 µM 0.109198618177528 0.460163819762571 no 1520 0.456522478145551 2108 50494 SGTC_2107 5363541 170.161 µM 0.109141681662026 0.460187336485353 no 1521 0.456545057574987 2232 244052 SGTC_1759 st043059 70 µM 0.108323863248856 0.460525138709112 no 1522 0.45686939692833 2107 669426 SGTC_971 1315-0384 26.7 µM 0.107408685277508 0.460903189344575 no 1523 0.457232382256908 2094 6769120 SGTC_942 3253-1115 227 µM 0.105758888336552 0.461584792587549 no 1524 0.457886828073589 2186 46497897 SGTC_711 k292-0785 179 µM 0.103694439729774 0.462437865289203 no 1525 0.458705919660484 2193 4146315 SGTC_231 b-estradiol 524 µM 0.103527733304915 0.4625067594117 no 1526 0.458772069877253 2119 450 A steroid. SGTC_608 k048-0125 159 µM 0.102840091124362 0.462790950514713 no 1527 0.459044942909504 2214 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_296 1222-0039 74.9 µM 0.101528359619847 0.463333119931636 no 1528 0.459565523073952 2138 5984176 SGTC_2287 7945887 168.79 µM 0.10105658706685 0.463528131306445 no 1529 0.459752770029824 2205 1245853 SGTC_2985 9022375 71.43 µM 0.100697770564922 0.463676457164507 no 1530 0.459895190605409 2138 4939335 SGTC_3201 9113999 49.47 µM 0.100441949824172 0.463782210209347 no 1531 0.459996733496694 2191 16649224 SGTC_1288 0973-0013 65.5 µM 0.0999554538554071 0.463983328518152 no 1532 0.460189845467927 2165 4315430 SGTC_435 c-PAF 6.7 µM 0.0993329306319456 0.464240694155742 no 1533 0.460436966420349 2234 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_3019 9081971 49.47 µM 0.0992990232541812 0.46425471268818 no 1534 0.460450426957882 2213 16451803 SGTC_3076 9116187 49.47 µM 0.0985854599610552 0.464549735746031 no 1535 0.460733707523121 2209 27241210 SGTC_1417 3966-0327 90.4 µM 0.0980757839249862 0.464760473469859 no 1536 0.460936058217108 2157 651118 SGTC_1067 clotrimazole 1.36 µM 0.097305376563777 0.465079035528827 no 1537 0.461241943192249 2133 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2536 dehydroabietamide 32.04 µM 0.096955795641985 0.465223594006201 no 1538 0.461380749481289 2213 3983547 SGTC_2310 7668677 200 µM 0.0968474021155205 0.46526841776042 no 1539 0.461423789694716 2188 2197143 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.096688227188299 0.465334241842426 no 1540 0.461486994683181 2062 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_157 1348-1695 65.819 µM 0.0966659086784962 0.465343471358158 no 1541 0.461495856967979 2249 5380510 SGTC_408 cantharidin 100 µM 0.0965369388555696 0.465396805436729 no 1542 0.461547068973878 2140 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1347 1493-0251 600 nM 0.0958916080404168 0.465663684348937 no 1543 0.461803329839868 2239 3986378 SGTC_2007 4011539 71.82 µM 0.0950485132497602 0.466012372523389 no 1544 0.462138146656861 2180 45595301 SGTC_2826 7992541 19.48 µM 0.093860573456249 0.466503726337747 no 1545 0.462609956673726 2261 2985066 SGTC_1859 st055998 20 µM 0.0926657066218087 0.466997996807085 no 1546 0.463084570949776 2251 676301 SGTC_2104 5389443 200 µM 0.0921031334975859 0.467230729347805 no 1547 0.463308049432987 2211 2244536 SGTC_2324 6149169 200 µM 0.0919757219243479 0.46728344017742 no 1548 0.463358664455445 2217 2888231 SGTC_2910 7948405 25.97 µM 0.090112329793184 0.468054400255186 no 1549 0.464098975662721 2220 2971328 SGTC_623 k072-0108 16.9 µM 0.0892687910410244 0.468403445652418 no 1550 0.464434148081419 2170 5382803 SGTC_1064 honokiol 6.76 µM 0.0887196079578128 0.468630703562482 no 1551 0.464652374543696 2140 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2699 st077704 54.6 µM 0.0877549258636265 0.469029924168222 no 1552 0.465035731720714 2174 645852 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.0867121716811761 0.469461488860241 no 1553 0.465450150629771 2270 1241132 A phosphatase inhibitor. SGTC_2849 9019321 12.99 µM 0.0850756379175579 0.47013887326931 no 1554 0.466100629099855 2204 16489627 SGTC_921 1561-0023 372 µM 0.0847039061853126 0.470292750391949 no 1555 0.466248395222082 2278 24050882 SGTC_2929 9013348 24.6 µM 0.0844280752598309 0.470406932560812 no 1556 0.466358043070174 2192 2995952 SGTC_2018 5133068 143 µM 0.0843145376578167 0.470453932964243 no 1557 0.466403177090131 2239 785362 SGTC_2618 avocadyne 43.43 µM 0.0842923162058296 0.470463131878614 no 1558 0.466412010720415 2184 3015189 SGTC_2775 cyproheptadine 69.59 µM 0.083152829458067 0.470934861091374 no 1559 0.466865009711013 2267 2913 A selective serotonin reuptake inhibitor. SGTC_2945 9067681 61.76 µM 0.0831161537188434 0.470950044939419 no 1560 0.466879590739643 2268 16456930 SGTC_2237 6667747 47.222 µM 0.0806344529795273 0.471977572244874 no 1561 0.467866332945143 2110 729940 YDL015C TSC13 SGTC_628 1636-0253 16 µM 0.0792797947899313 0.472538536208167 no 1562 0.468405038565535 2244 4456143 SGTC_2056 5235370 200 µM 0.079145163507511 0.472594290017052 no 1563 0.468458580435184 2188 5511916 SGTC_2135 5326629 150.42 µM 0.0788352473124447 0.472722635246349 no 1564 0.468581833990511 2190 5020077 SGTC_1723 st034307 2.5525 µM 0.0781347402508715 0.473012745826444 no 1565 0.468860436465742 2216 867466 SGTC_1221 2958-7315 257 µM 0.078104503258084 0.473025268609647 no 1566 0.468872462528975 2197 4562705 SGTC_2149 5554786 194.827 µM 0.0769021650506006 0.473523243730519 no 1567 0.469350687594309 2189 745063 YPR165W RHO1 SGTC_3033 9090887 49.47 µM 0.0763941783219428 0.473733650216164 no 1568 0.469552750549366 2220 19325384 SGTC_2176 5809774 33.9695 µM 0.0759902644455425 0.473900955290246 no 1569 0.46971342182488 2265 2870539 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.0757811211073728 0.473987586315121 no 1570 0.469796618051299 2200 279621 SGTC_1011 4112-3381 17.4 µM 0.0749256458651965 0.47434195268825 no 1571 0.47013693572765 2199 2877139 SGTC_1993 st073995 70.8 µM 0.0747856477748118 0.474399946506307 no 1572 0.47019263062674 2193 3098394 SGTC_2026 5148700 152 µM 0.0712040119557057 0.47588381019734 no 1573 0.471617694222469 2264 79838 SGTC_1450 4112-4260 37.6 µM 0.0706229661122419 0.476124568265759 no 1574 0.471848915866736 2282 1633175 SGTC_2592 piperlongumine 83.33 µM 0.0701348823165999 0.476326813973872 no 1575 0.472043151487849 2190 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1831 st055328 12 µM 0.0696907771710868 0.476510841691012 no 1576 0.472219891342792 2269 1103068 SGTC_283 0987-0079 11.7 µM 0.0687381096647411 0.476905623672934 no 1577 0.472599041401805 2257 411556 SGTC_3088 9117578 49.47 µM 0.0683483371695333 0.477067150546618 no 1578 0.472754173282297 2279 678341 SGTC_1149 3909-7961 23.3 µM 0.0681268736028917 0.477158929656069 no 1579 0.472842319003758 2131 735261 SGTC_1889 st059080 5.18 µM 0.0679102670291444 0.477248697098633 no 1580 0.472928532857905 2282 176925 Isolated from Daphnopsis sellowiana. SGTC_10 0279-0212 42.575 µM 0.0664199854850766 0.477866339891939 no 1581 0.473521729609643 2288 39851 YBR002C RER2 SGTC_1994 st072947 40.9 µM 0.0655819987208878 0.478213664484172 no 1582 0.473855310597498 2196 5286565 YDL195W SEC31 SGTC_809 3998-0021 90 µM 0.064806571455722 0.47853507447196 no 1583 0.474164004593423 2298 715485 SGTC_95 0471-0001 561.058 µM 0.0641795048249464 0.478795000078358 no 1584 0.474413648262808 2147 4015405 SGTC_2361 9034121 116 µM 0.0641389977567478 0.478811790988531 no 1585 0.474429775018619 2216 6496917 SGTC_2406 ethylparaben 405.7 µM 0.0635213110155917 0.479067837921843 no 1586 0.474675694886924 2011 8434 A possible steroid mimic. SGTC_25 0118-0223 35.662 µM 0.0633597812469599 0.479134797566497 no 1587 0.474740006393448 2275 5333628 SGTC_1769 st044406 64.4 µM 0.0632496194029309 0.479180463777552 no 1588 0.47478386663795 2177 670903 SGTC_2980 9014342 25.29 µM 0.0627744902413498 0.479377425737271 no 1589 0.474973039816489 2205 2996599 SGTC_2111 5486399 200 µM 0.062592545502239 0.479452851179597 no 1590 0.475045482803282 2288 689674 SGTC_1964 st076914 61 µM 0.0608977507583761 0.480155465664116 no 1591 0.475720320378984 2315 24208661 SGTC_3287 9117173 37.0625 µM 0.0608973450563435 0.480155633864297 no 1592 0.475720481930842 2312 2789709 SGTC_2936 9038235 15.59 µM 0.0576553234068341 0.48149985530959 no 1593 0.477011590608879 2305 4749415 SGTC_720 r052-1644 49.9 µM 0.0565310259564403 0.481966066425796 no 1594 0.47745938994876 2251 1422863 YOR257W CDC31 SGTC_1581 himbacine 57.9 µM 0.0560149624758908 0.482180070166039 no 1595 0.477664943771961 2245 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2373 9071805 200 µM 0.054895735522137 0.482644214260946 no 1596 0.478110764659098 2326 10149009 SGTC_178 4092-0806 87.505 µM 0.0548921439954027 0.482645703707455 no 1597 0.478112195313811 2317 2169044 SGTC_1806 st050005 60.3 µM 0.0547096027965452 0.482721405913124 no 1598 0.478184909448626 2238 5194765 SGTC_149 3970-0822 46.1 µM 0.0539363673512016 0.483042083569294 no 1599 0.478492930933704 2303 3114250 YBL034C STU1 SGTC_2091 4-phenylthiadiazole 200 µM 0.053550893899987 0.483201951953639 no 1600 0.478646490660945 2283 270010 SGTC_793 0488-0545 106 µM 0.052921571976683 0.483462958026938 no 1601 0.478897198263401 2204 292548 SGTC_2736 butenafine 14.65 µM 0.0528004960863234 0.483513174069432 no 1602 0.478945433117015 2278 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1233 0325-0408 14.2 µM 0.0527847192232196 0.48351971751883 no 1603 0.478951718409912 2280 12874 SGTC_850 0388-0143 75.9 µM 0.052084529918262 0.483810125274222 no 1604 0.479230669785513 2263 67273 SGTC_3065 9113888 49.47 µM 0.0515178725339233 0.484045156151887 no 1605 0.479456430269494 2282 16648368 SGTC_2707 st078556 66.6 µM 0.0507512302814998 0.484363142994939 no 1606 0.479761876677478 2318 17250899 SGTC_847 0342-0274 5.54 µM 0.050410367299771 0.484504528890239 no 1607 0.47989768749053 2298 18097 SGTC_2326 6164455 177.58 µM 0.0488962138594438 0.485132604962442 no 1608 0.480501003078752 2280 2888790 SGTC_1272 0839-0021 27 µM 0.0485678911831439 0.485268799261505 no 1609 0.480631829439024 2264 5027250 SGTC_2476 5806916 10.51 µM 0.0472494585348681 0.485815726575645 no 1610 0.481157204650778 2286 2870194 SGTC_1915 st067105 30.6 µM 0.0465368250427722 0.486111360528057 no 1611 0.481441191864269 2320 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1905 st060207 84.5 µM 0.0458346831296602 0.486402649545439 no 1612 0.481721007354748 2229 1948547 SGTC_2706 st078239 82.5 µM 0.0458232970184422 0.486407373222168 no 1613 0.481725544988232 2334 15434492 SGTC_195 4234-0266 16.654 µM 0.0456254470495052 0.486489454165919 no 1614 0.481804393238056 2265 2303354 SGTC_2005 4024620 188 µM 0.0451534081140491 0.486685288704716 no 1615 0.481992515640917 2328 236743 SGTC_2714 st079313 56.9 µM 0.0445837328964222 0.486921633826683 no 1616 0.482219554517158 2311 2939799 SGTC_1025 k007-0731 70 µM 0.0443414620772135 0.487022147804415 no 1617 0.482316111100381 2311 6256118 SGTC_3132 9126706 49.47 µM 0.0433795688703107 0.487421228751608 no 1618 0.482699482023763 2278 850858 SGTC_1473 k844-0725 134 µM 0.0431839119580589 0.487502406621166 no 1619 0.482777464761286 2338 54682906 SGTC_2188 6126565 140.678 µM 0.042884253902242 0.487626735470402 no 1620 0.482896900384405 2324 874518 SGTC_247 mechlorethamine 29.705 µM 0.0425777001367376 0.487753926610446 no 1621 0.483019086039648 2309 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2180 6301957 200 µM 0.0423444115985564 0.487850720369109 no 1622 0.483112070839991 2332 845462 SGTC_1942 st076330 65.2 µM 0.0411348195600114 0.488352603607797 no 1623 0.483594208045221 2292 24208414 SGTC_64 000l-0018 272.079 µM 0.0410858422951623 0.488372925620488 no 1624 0.4836137306428 2326 6811119 SGTC_2136 5328288 199.296 µM 0.0408838593705153 0.488456734203183 no 1625 0.483694242522583 2300 262395 SGTC_2710 st078562 53.7235 µM 0.0400829993770981 0.488789039259276 no 1626 0.484013477720333 2335 17250908 SGTC_75 0159-0059 199.013 µM 0.0389872865011406 0.489243701737759 no 1627 0.484450262405236 2325 5377270 SGTC_2009 4012297 12.05 µM 0.0387236059484165 0.48935311723068 no 1628 0.484555376348315 2274 45595307 SGTC_881 0833-0569 170 µM 0.0386536210674682 0.489382157923047 no 1629 0.484583275388728 2286 5418700 SGTC_2089 5281248 129.67 µM 0.0382454817526025 0.489551519165904 no 1630 0.484745979104149 2317 2737878 SGTC_960 1222-0186 7.7 µM 0.0380919206077364 0.489615241294955 no 1631 0.484807196528863 2308 3126296 SGTC_1005 4092-0690 4.4 µM 0.0379801585483804 0.489661618534343 no 1632 0.484851750898701 2300 1529343 SGTC_379 3970-0972 5.9 µM 0.0379668485765141 0.48966714170381 no 1633 0.484857056982198 2288 2898042 YBL034C STU1 SGTC_1327 1436-0082 2.18 µM 0.0368956562358597 0.490111655195986 no 1634 0.485284101606285 2204 15992205 SGTC_1559 coumarin 343 70.1 µM 0.0348086827529215 0.490977722926229 no 1635 0.486116148496522 2327 108770 A hepatotoxic, DNA x-linker. SGTC_155 k072-0202 43.6 µM 0.0347749415270539 0.490991725470738 no 1636 0.486129601153628 2354 5857737 SGTC_2286 7945697 125 µM 0.0345420726436415 0.491088365915869 no 1637 0.486222446616505 2301 1245733 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.0333029563678178 0.491602607077713 no 1638 0.486716498114216 2205 688788 SGTC_2511 berberine 10.47 µM 0.0327689601141073 0.491824223284124 no 1639 0.486929415576813 2339 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.032550861702431 0.491914738024565 no 1640 0.487016377861956 2353 4000243 SGTC_2292 7671323 168.05 µM 0.0319768573532576 0.492152962070283 no 1641 0.487245253307123 2301 937504 SGTC_171 k064-0041 9.68 µM 0.0315806711098127 0.492317389447779 no 1642 0.487403228960366 2304 53325 SGTC_309 k408-0051 1.48 µM 0.0308318561235726 0.492628170273771 no 1643 0.487701817488835 2324 3640463 SGTC_3157 9099274 49.47 µM 0.0307841027504514 0.492647989519067 no 1644 0.487720859289671 2345 17217662 SGTC_1387 3342-1166 1.8 µM 0.0305239926024859 0.4927559442382 no 1645 0.487824579482105 2295 3418228 SGTC_2252 omeprazole 400 µM 0.0300974682892487 0.492932967743599 no 1646 0.487994659915157 2318 4594 A proton pump inhibitor. SGTC_3301 9125354 19.7965 µM 0.0279302362913357 0.493832470661175 no 1647 0.488858896386239 2340 41905162 SGTC_571 k831-0106 44.2 µM 0.0279286054168043 0.493833147562972 no 1648 0.488859546757332 2360 4783639 SGTC_2925 9010536 32.5 µM 0.02771466122523 0.493921946213527 no 1649 0.488944865114393 2321 2994177 SGTC_1655 st012546 55.1 µM 0.0274933927468851 0.494013785164209 no 1650 0.489033104840585 2328 720985 YLR208W SEC13 SGTC_2150 5556613 200 µM 0.0274602403707839 0.494027545305419 no 1651 0.48904632573344 2334 743190 SGTC_1734 st037168 69.4 µM 0.0274080366290653 0.494049212872562 no 1652 0.489067144177417 2184 708907 SGTC_135 0933-0004 26.348 µM 0.0272173164719291 0.494128372899023 no 1653 0.489143202137471 2335 21230617 YGL099W LSG1 SGTC_147 4466-0538 29.23 µM 0.0271391173153858 0.494160830192343 no 1654 0.489174387567529 2278 6742687 YHR072W ERG7 SGTC_357 1325-0123 420 µM 0.0269402717382941 0.494243363087625 no 1655 0.489253686480566 2354 1098503 SGTC_697 0508-1955 564 µM 0.0263281380343457 0.494497436988398 no 1656 0.489497805890343 2356 6243113 SGTC_1475 4092-1048 11.7 µM 0.0252835108363202 0.494931027928643 no 1657 0.489914413087041 2302 2881759 SGTC_1833 st055984 71 µM 0.0252719766270024 0.494935815439991 no 1658 0.489919013100952 2333 676288 SGTC_2801 7907800 81.82 µM 0.0242931503349571 0.495342100057526 no 1659 0.490309388380572 2346 6620925 SGTC_1780 st038448 24.544 µM 0.0236654870110749 0.495602628886852 no 1660 0.490559717833187 2344 728868 YDL195W SEC31 SGTC_2184 6075246 200 µM 0.0232890275766101 0.495758889578294 no 1661 0.490709862033501 2328 2267320 SGTC_1055 3448-0672 86 µM 0.0229184829574053 0.495912695785227 no 1662 0.490857648499779 2338 748378 SGTC_414 piperonyl butoxide 100 µM 0.0222332717704378 0.496197115838623 no 1663 0.491130938555141 2357 5794 A potent inhibitor of cytochrome P450. SGTC_3323 9138564 53.9225 µM 0.0213947253906401 0.496545185459955 no 1664 0.491465390566272 2375 43912313 YNL103W MET4 SGTC_962 1254-0300 21.5 µM 0.0211544331950342 0.496644928100108 no 1665 0.491561231590871 2358 7340576 SGTC_31 0508-1974 57.237 µM 0.0210972787068336 0.496668652328897 no 1666 0.491584027845153 2369 6810525 SGTC_88 0180-0332 8.668 µM 0.0210813549458627 0.496675262117218 no 1667 0.491590379094122 2376 3101745 SGTC_776 4476-4378 112 µM 0.0201103854341784 0.497078303165171 no 1668 0.491977657721557 2255 2892008 SGTC_3314 9135860 59.4275 µM 0.0196927291524202 0.497251669617395 no 1669 0.492144245476177 2366 25252478 SGTC_1469 k284-2957 126 µM 0.0181941685593958 0.497873716577997 no 1670 0.492741977341624 2334 23884841 SGTC_1910 st062352 60.4 µM 0.0177483294193262 0.498058783822516 no 1671 0.492919812703695 2361 2245730 SGTC_3110 9122132 49.47 µM 0.0170492028619668 0.498348991168995 no 1672 0.493198681628713 2362 918317 SGTC_1540 guanosine 70.6 µM 0.016875789949597 0.498420974988409 no 1673 0.493267853419352 2371 6802 Guanosine is a purine nucleoside SGTC_1567 st069303 68.4 µM 0.0165006473802577 0.498576697100225 no 1674 0.493417492812077 2339 5581319 SGTC_993 3909-8757 62.7 µM 0.0162707810352005 0.498672114992989 no 1675 0.493509183905788 2360 4288324 YLR208W SEC13 SGTC_564 3555-0129 330 µM 0.0150774282273363 0.49916747877789 no 1676 0.493985204290685 2386 563260 SGTC_825 1988-2224 89.6 µM 0.0137683817287502 0.499710868755883 no 1677 0.494507383933924 2372 1180859 SGTC_3175 9106517 49.47 µM 0.0132845824485771 0.499911695791737 no 1678 0.494700374264016 2371 41468073 SGTC_66 0109-0187 42.4 µM 0.0128591267092147 0.499911695791737 no 1679 0.494870092044862 2381 759417 SGTC_471 1-acyl-paf 4 µM 0.0114020379595104 0.499306852638743 no 1680 0.495451343534551 2379 16759367 SGTC_1959 st077091 55.8 µM 0.010470206376802 0.498920046506854 no 1681 0.495823068308081 2378 821356 YKL052C ASK1 SGTC_3193 9111931 49.47 µM 0.0100398935086941 0.498741422643581 no 1682 0.495994729276956 2388 17087244 SGTC_1513 0337-0559 19 µM 0.0090969466990698 0.498350004181696 no 1683 0.496370893393366 2382 775073 SGTC_978 1416-0512 87.4 µM 0.00893520626397583 0.498282865663321 no 1684 0.496435415868747 2379 6814003 SGTC_3309 9129340 25.759 µM 0.0080083445204071 0.497898125983856 no 1685 0.496805166924173 2390 17158987 SGTC_2799 7812892 81.82 µM 0.00738340258201563 0.497638714091701 no 1686 0.4970544752992 2382 20205235 SGTC_2829 7992743 58.44 µM 0.00682441666389055 0.497406681227226 no 1687 0.497277472786271 2398 16462845 SGTC_3015 9080845 49.47 µM 0.0066051414550801 0.497315661182407 no 1688 0.497364948965838 2388 5296973 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.00627272851500481 0.497177678498023 no 1689 0.497497559792533 2385 5379071 SGTC_443 clozapine 122 µM 0.00550766410872923 0.496860106008156 no 1690 0.497802771029375 2397 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1030 k029-0042 36.7 µM 0.00527352867209691 0.496762918534965 no 1691 0.497896176197056 2360 6080581 SGTC_2231 micatex 6.853 µM 0.00412490228787473 0.496286137145402 no 1692 0.498354406741422 2397 20737 An antifungal of unknown mechanism. SGTC_1895 st058434 18.3 µM 0.00410662680636374 0.496278551247656 no 1693 0.49836169754194 2397 5393175 SGTC_1467 k284-1082 293 µM 0.00330780286754439 0.495946971913589 no 1694 0.498680379987354 2397 3334705 SGTC_3297 9117502 71.43 µM 0.00310692691858197 0.49586359187778 no 1695 0.49876051748418 2398 7453720 SGTC_3231 9132313 49.47 µM 0.00288948534415897 0.495773335949079 no 1696 0.498847263731672 2392 4905967 SGTC_2969 9091408 28.7 µM 0.00233392407633329 0.495542733856093 no 1697 0.499068899852019 2399 4286311 SGTC_1458 k015-0034 6.33 µM 0.00127202118347693 0.49510196394408 no 1698 0.499492537105194 2400 3598957 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.000616667989371365 0.494829945815596 no 1699 0.499753985081662 2404 5711223 A potent inhibitor of glutathione S-transferases. SGTC_1265 0819-1001 68.8 µM 0.000302098221045948 0.494699377862396 no 1700 0.499879480248624 2404 3106768 SGTC_3276 9139060 49.47 µM -4.38184863908568e-05 0.494555799443129 no 1701 0.499982518953121 2406 4870619 SGTC_1308 1187-1617 41.4 µM -0.00116462456224109 0.494090595385552 no 1702 0.499535382126359 2407 2882570 SGTC_177 1327-0068 8.361 µM -0.00150822128185268 0.493947983009973 no 1703 0.499398306990583 2410 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3042 9091578 49.47 µM -0.00362314070294822 0.493070187687531 no 1704 0.498554579148127 2405 25236497 SGTC_2721 ifenprodil 61.44 µM -0.00367883554697981 0.493047072029566 no 1705 0.498532360268131 2410 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2071 5230951 39.92 µM -0.00406037074310021 0.492888719814817 no 1706 0.498380150887444 2413 1799272 SGTC_1037 k284-1091 78.7 µM -0.0046099794162953 0.492660612427866 no 1707 0.498160890813159 2393 3334711 SGTC_2201 6605497 169.863 µM -0.00577377130269699 0.492177604908194 no 1708 0.497696611307787 2424 670741 SGTC_1105 epirubicin 18.1 µM -0.00583143610619436 0.49215367262807 no 1709 0.497673606766872 2413 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2436 5633522 8.09 µM -0.00623178817815385 0.491987517674346 no 1710 0.497513892304647 2421 5724242 SGTC_515 4092-1064 102 µM -0.00725624486459586 0.49156235191748 no 1711 0.497105202529928 2418 717353 SGTC_2449 5812982 45.77 µM -0.0087036127044597 0.490961687783064 no 1712 0.496527804738136 2412 776185 SGTC_1531 st059297 52.4 µM -0.00874916445016274 0.490942783930169 no 1713 0.496509632912734 2427 7566702 SGTC_421 streptovitacin 30 mM -0.00884062529678654 0.49090482798439 no 1714 0.496473146725161 2507 91467 include heat shock SGTC_2852 9023854 51.95 µM -0.00891914063161399 0.490872244448439 no 1715 0.496441824873372 2435 19798528 SGTC_2165 5727197 32.143 µM -0.0099128780862911 0.490459852893194 no 1716 0.496045398577605 2466 1361712 SGTC_303 1348-1668 34.2 µM -0.010026045681484 0.490412890060283 no 1717 0.49600025348268 2428 5380509 SGTC_3332 9141069 11.198 µM -0.0102314287291688 0.490327659555334 no 1718 0.495918321704277 2419 17332883 SGTC_771 0250-0039 27.3 µM -0.0103468363183543 0.490279767543511 no 1719 0.495872283174525 2423 3005115 SGTC_3010 9080089 71.4286 µM -0.010950543688716 0.490029242467026 no 1720 0.495631452437994 2419 17027233 SGTC_1920 st075728 45.7 µM -0.0109834849687272 0.490015572683756 no 1721 0.495618311558914 2424 3400306 SGTC_447 ml7 120 µM -0.0112353156971672 0.489911069802471 no 1722 0.4955178518336 2426 4216 Selective myosin light chain kinase inhibitor. SGTC_2238 6671620 73.2395 µM -0.0120384688799004 0.489577787806629 no 1723 0.495197461773886 2421 729941 SGTC_3242 9133940 49.47 µM -0.0121224811716531 0.489542925901776 no 1724 0.495163948164184 2449 17248444 SGTC_1764 st044502 93.5 µM -0.0122640272452448 0.489484189847143 no 1725 0.49510748364845 2448 8407 SGTC_54 0159-0055 9 µM -0.0123572488334836 0.489445506678181 no 1726 0.495070296433471 2430 3319099 SGTC_2124 5246320 200 µM -0.0128792354326103 0.489228905306863 no 1727 0.494862070489171 2451 579342 SGTC_2970 9090938 41.86 µM -0.0136745694949479 0.488898882946788 no 1728 0.494544806077327 2436 17217104 SGTC_2438 5259590 200 µM -0.0138751942304768 0.488815635285012 no 1729 0.494464775981075 2449 1201127 SGTC_1195 1502-0147 41.1 µM -0.0150983964430476 0.488308087787839 no 1730 0.493976840134977 2423 817940 SGTC_788 1182-0090 188 µM -0.0155157420761135 0.488134921421184 no 1731 0.493810362822104 2480 5715185 SGTC_1278 0874-0585 172 µM -0.0162139424005877 0.487845226957529 no 1732 0.493531856249451 2445 766306 SGTC_1752 st044819 83.042 µM -0.0162748982652352 0.487819935698108 no 1733 0.493507541586111 2444 441209 YML126C ERG13 SGTC_1042 0350-0096 82 µM -0.0166345322876582 0.487670720582697 no 1734 0.49336408779179 2437 3122515 SGTC_1404 3909-7820 48.3 µM -0.017432838911811 0.487339502792868 no 1735 0.493045655734461 2441 23741373 SGTC_700 3453-2283 142 µM -0.0175406528214065 0.487294771415878 no 1736 0.493002650783193 2447 565664 SGTC_2677 mitomycin C 100 µM -0.0175956710630186 0.487271944722373 no 1737 0.492980705067351 2435 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2321 7390090 138.78 µM -0.0176897589304606 0.487232908404033 no 1738 0.492943175280286 2453 649046 SGTC_1258 0671-0043 57.1 µM -0.0179963381709418 0.487105711932048 no 1739 0.492820887327669 2456 4298767 SGTC_2979 9012552 45.46 µM -0.0180915494183259 0.487066210062672 no 1740 0.492782909718484 2441 17100905 SGTC_2179 6298986 200 µM -0.0187806609945854 0.486780310720308 no 1741 0.49250804069682 2458 738374 SGTC_3241 9133421 49.47 µM -0.0195328276331479 0.486468258786974 no 1742 0.492208024684978 2439 17018221 SGTC_43 0570-0105 72.5 µM -0.0195694430149551 0.486453068346199 no 1743 0.492193420052617 2438 1114046 YDL195W SEC31 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.0198880643954113 0.486320884315806 no 1744 0.492066333248057 2443 803109 SGTC_90 0870-0863 4.608 µM -0.0209024227029673 0.485900075273274 no 1745 0.491661747004842 2440 1738164 SGTC_312 4092-0653 6.84 µM -0.0219067409123845 0.485483446856792 no 1746 0.491261173798004 2505 1148278 SGTC_1770 st043884 66.3 µM -0.0219636154055219 0.48545985367889 no 1747 0.491238489615945 2447 670149 SGTC_3196 9111891 49.47 µM -0.0235999559550375 0.484781074613251 no 1748 0.490585853642599 2442 18891510 SGTC_3198 9112019 49.47 µM -0.0236776598109324 0.484748842947615 no 1749 0.490554862949044 2455 45595555 SGTC_2487 5918373 44.05 µM -0.0239713106043309 0.484627037098752 no 1750 0.490437746475034 2447 2876279 SGTC_305 1682-2595 20.8 µM -0.0251652210968076 0.484131819952277 no 1751 0.489961588854825 2484 226033 SGTC_2828 7998861 71.43 µM -0.0252206706924243 0.484108820834987 no 1752 0.489939474685579 2453 2988188 SGTC_1460 k062-0059 9.15 µM -0.0260617425911397 0.483759971594657 no 1753 0.489604045839783 2411 1373085 SGTC_2459 5811157 9.22 µM -0.0262732378326827 0.483672252199729 no 1754 0.489519700328198 2454 2870684 YBR192W RIM2 SGTC_36 0335-0881 14.2 µM -0.0275663384827724 0.483135945389411 no 1755 0.489004014728064 2446 23828853 SGTC_3072 9116419 49.47 µM -0.0291331638018247 0.482486153662151 no 1756 0.488379193063841 2468 17170162 SGTC_279 1273-0055 2.93 µM -0.0308608367563597 0.481769709412588 no 1757 0.48769026138821 2455 2847562 SGTC_2512 diallyl trisulfide 49.23 µM -0.0310168424100677 0.48170501869323 no 1758 0.487628053917016 2447 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2859 9028643 45.46 µM -0.0312643578138944 0.481602382700027 no 1759 0.487529357424053 2509 17151580 SGTC_2882 9058044 58.44 µM -0.0316544897077205 0.481440611107881 no 1760 0.48737379431675 2492 18076804 SGTC_205 1486-1330 71.903 µM -0.0317660449231434 0.481394354325631 no 1761 0.487329312594464 2448 4118834 SGTC_1872 amphotericin b 148 nM -0.0331011127579694 0.480840783129549 no 1762 0.486796977692508 2469 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1953 st076800 12.1 µM -0.0335334666261111 0.480661520220493 no 1763 0.486624589161547 2496 297591 SGTC_1118 chelidonine 707.474 nM -0.0356796277228665 0.479771735772279 no 1764 0.485768907464869 2466 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1510 1123-0200 71.5 µM -0.0365580640531818 0.479407570593981 no 1765 0.485418690599227 2488 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2550 chrysin dimethyl ether 71.87 µM -0.0366784142283816 0.479357679473306 no 1766 0.485370710005181 2462 88881 An O-methylated flavonoid and antioxidant. SGTC_3056 9094900 49.47 µM -0.0367112242647691 0.479344078140911 no 1767 0.485357629503921 2493 25236784 SGTC_3089 9117425 49.47 µM -0.0367860495109005 0.479313059580638 no 1768 0.485327798699096 2518 9401657 SGTC_1609 st001574 46.4 µM -0.036929526504896 0.479253582014141 no 1769 0.485270598526292 2469 3960012 SGTC_1138 3761-0006 1.03 µM -0.0374611072516681 0.479033222295577 no 1770 0.485058675141278 2457 12061087 SGTC_1849 st056239 19.2 µM -0.0375921666841262 0.478978894335595 no 1771 0.485006426794745 2482 5393181 SGTC_735 3076-0345 636 µM -0.0380186001516213 0.478802127925013 no 1772 0.484836425986063 2487 2888990 SGTC_420 mitomycin C 81.9 mM -0.0382448523262405 0.478708342922539 no 1773 0.48474623002536 2474 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2254 7938975 95.19 µM -0.0385603669144733 0.478577559247655 no 1774 0.484620450697942 2508 2969277 SGTC_2843 9000894 45.46 µM -0.038679703211847 0.478528093864285 no 1775 0.484572877894181 2465 2242070 SGTC_16 erodoxin 22.806 µM -0.0398814226120886 0.478029994820579 no 1776 0.484093830963401 2489 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_154 3389-1638 511.116 µM -0.0430013843697604 0.476736968230815 no 1777 0.48285021515425 2555 5238686 SGTC_456 gingerol 170 µM -0.0437241084381468 0.476437479305514 no 1778 0.482562160918107 2539 442793 A herb. SGTC_322 k048-0136 19.3 µM -0.0438240574347906 0.476396062581555 no 1779 0.482522325221757 2550 6823282 SGTC_2753 fluvastatin 17.09 µM -0.0443721680533626 0.476168941823407 no 1780 0.482303873233326 2540 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1520 flindersine 88 µM -0.0450767246536366 0.475877005880239 no 1781 0.482023076798026 2573 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1662 st014054 52 µM -0.0460960045980149 0.475454685974967 no 1782 0.481616865247063 2481 2838777 SGTC_3062 9077494 49.47 µM -0.0462328437400751 0.47539799128128 no 1783 0.481562332467572 2491 16459633 SGTC_2838 9002687 71.43 µM -0.0466386640490632 0.475229856226245 no 1784 0.481400608044714 2484 6457060 SGTC_1602 st001878 87.6 µM -0.0473424897654445 0.474938265289323 no 1785 0.481120132046737 2644 595405 YLR310C CDC25 SGTC_540 1187-0821 17.3 µM -0.0484238165322542 0.47449030405148 no 1786 0.480689239359341 2497 847520 SGTC_1883 5-benzylidenerhodanine 20 µM -0.0489908752186253 0.47425540150496 no 1787 0.480463283864968 2503 1273210 SGTC_2082 5219693 150 µM -0.0512716086571547 0.473310704988859 no 1788 0.479554545674253 2487 2834649 SGTC_3090 9117696 49.47 µM -0.0513368534700325 0.473283682291773 no 1789 0.479528550992959 2602 7923821 SGTC_398 bronopol 33.3 µM -0.0516133044842492 0.473169184869079 no 1790 0.47941840901269 2507 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_493 zm226600 134 µM -0.054111427230127 0.472134641692216 no 1791 0.478423193987257 2610 5240098 A potassium channel opener. YCR052W RSC6 SGTC_634 1611-4317 11.2 µM -0.0543342515938445 0.472042372858675 no 1792 0.478334430511081 2494 2843522 SGTC_1210 3013-0140 750 nM -0.0550306642431311 0.47175400662523 no 1793 0.478057017133222 2548 905973 SGTC_2673 kobusone 100 µM -0.0557909971277562 0.471439189609746 no 1794 0.47775415351292 2523 6710676 An epoxy ketone and protein crosslinker. SGTC_1424 4048-1941 275 µM -0.0563104075999828 0.471224137142033 no 1795 0.477547263962884 2571 X1424 SGTC_619 1652-1634 108 µM -0.0566171095080587 0.471097156726104 no 1796 0.477425102494955 2533 5400454 SGTC_2481 5478948 45.16 µM -0.0568007487673713 0.471021127989982 no 1797 0.477351958736387 2585 77792 SGTC_2921 7974240 10.71 µM -0.0581225853029605 0.47047390400323 no 1798 0.476825492165701 2553 2979074 YDR527W RBA50 SGTC_1369 1866-0067 208 µM -0.0598867578403793 0.469743645416956 no 1799 0.476122913338786 2486 3531355 SGTC_2863 9028737 58.44 µM -0.0600525356085878 0.469675028841138 no 1800 0.476056896395067 2612 6460917 SGTC_3003 9075612 71.4286 µM -0.0606355431906158 0.469433725098059 no 1801 0.475824733109175 2583 6501993 SGTC_3182 9108849 49.47 µM -0.0623406398933542 0.468728059378682 no 1802 0.475145782721138 2566 17133045 SGTC_1228 0124-0032 52.5 µM -0.0634497457205382 0.468269101076605 no 1803 0.474704187831872 2557 X1228 SGTC_1106 tegaserod maleate 11.7 µM -0.0641401387892752 0.467983431262867 no 1804 0.474429320747871 2567 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_73 0327-0325 16.231 µM -0.064209702310184 0.467954648284827 no 1805 0.474401626006265 2649 53298 SGTC_854 0422-0053 192 µM -0.0645045419684408 0.467832655697325 no 1806 0.474284245338874 2528 3596728 SGTC_3294 9122953 26.2835 µM -0.0645314594461179 0.46782151849668 no 1807 0.474273529145639 2511 16459826 SGTC_3098 9119039 49.47 µM -0.0661318158258908 0.467159411009543 no 1808 0.47363644045995 2515 17161528 SGTC_207 4185-0010 4.486 µM -0.0664896809873952 0.467011365601259 no 1809 0.473493986454987 2518 3761753 SGTC_775 4577-0580 57.3 µM -0.066514469193003 0.467001111125498 no 1810 0.473484119234876 2713 2006902 SGTC_2934 9036370 36.88 µM -0.0672652476466637 0.466690536751718 no 1811 0.473185271282582 2591 6462800 SGTC_2451 5856223 45.7 µM -0.0686472876818602 0.466118881689464 no 1812 0.472635188746068 2557 2179896 SGTC_2052 5265182 7.135 µM -0.0687548168567398 0.466074407169012 no 1813 0.472592391928069 2565 1239884 SGTC_1093 fluphenazine 7.97 µM -0.0690665226345209 0.465945486740158 no 1814 0.472468334219936 2540 6602611 An atypical antipsychotic. SGTC_2893 9048488 25.97 µM -0.0697112889775014 0.465678824972748 no 1815 0.472211728169373 2554 6467338 SGTC_1943 st076331 65.2 µM -0.072157515009671 0.464667258597341 no 1816 0.471238277553689 2536 24208415 SGTC_1356 1502-0781 85.8 µM -0.0734128460953476 0.464148240787587 no 1817 0.470738797736977 2519 567702 SGTC_877 0771-0151 33.1 µM -0.0736849869914416 0.464035731895486 no 1818 0.47063052247846 2635 6166523 SGTC_2270 7924575 90.91 µM -0.0742140223939141 0.463817025533741 no 1819 0.470420044181899 2685 1262135 SGTC_947 3447-0010 211 µM -0.0771075085717401 0.462621036418282 no 1820 0.469269009905141 2524 748350 SGTC_1362 1611-0397 101 µM -0.077287657016252 0.462546585198086 no 1821 0.469197354905191 2547 27816 SGTC_1185 1319-0113 81.3 µM -0.0789121058071091 0.46187529734441 no 1822 0.468551267114552 2618 4672763 SGTC_860 0443-0016 25.1 µM -0.0789647825194928 0.461853531006647 no 1823 0.468530317519953 2552 5337942 SGTC_1390 3413-2614 145 µM -0.079014677148063 0.461832914348184 no 1824 0.468510474443935 2569 3421432 SGTC_3337 9144342 33.5465 µM -0.0808446855312358 0.461076818938533 no 1825 0.467782735217949 2636 17682949 SGTC_2622 2-methoxyxanthone 59.94 µM -0.0813062883178713 0.460886122934985 no 1826 0.467599186597722 2621 71034 A hepatoprotective. SGTC_315 k915-0449 187 µM -0.0813783751055524 0.460856343461337 no 1827 0.467570523114337 2573 20970215 YNL149C PGA2 SGTC_930 2810-3379 265 µM -0.0820319066792931 0.460586375782051 no 1828 0.467310670544573 2611 1015764 SGTC_3217 9129673 49.47 µM -0.08250800587114 0.46038971516301 no 1829 0.467121376139232 2642 17248312 SGTC_3190 9110366 49.47 µM -0.0830871419871899 0.460150506509443 no 1830 0.466891124850572 2562 17123768 SGTC_2218 6965428 192.983 µM -0.0848488922776161 0.459422915284125 no 1831 0.466190761619851 2561 675684 SGTC_1782 st039423 80.636 µM -0.0870139224329741 0.458528958490886 no 1832 0.465330222790801 2600 2068169 SGTC_2917 7979103 53.79 µM -0.0876670595342105 0.458259314370203 no 1833 0.465070650736058 2639 2980565 SGTC_2898 9056270 58.44 µM -0.088754361295551 0.45781047038078 no 1834 0.464638564447156 2549 19154699 SGTC_2603 homopterocarpin 100 µM -0.0891045077840686 0.457665939460102 no 1835 0.464499427476951 2648 101795 A weak amylase inhibitor. SGTC_1331 1472-0049 76.2 µM -0.0894332839478347 0.457530234722378 no 1836 0.464368786338849 2562 24051409 SGTC_2073 5212005 126 µM -0.089770996689479 0.457390846502792 no 1837 0.464234598198503 2553 691789 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.0907173272530375 0.457000284144712 no 1838 0.463858601122658 2633 23847180 SGTC_864 0469-0573 172 µM -0.0917706921573714 0.456565596244395 no 1839 0.463440115022362 2565 689425 SGTC_2407 paclitaxel 400 µM -0.091892679654857 0.456515259497589 no 1840 0.463391653821441 2853 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2629 bisabolol 100 µM -0.0928833284138527 0.456106505521606 no 1841 0.462998125241532 2652 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_980 1473-0395 201 µM -0.0932431908503079 0.455958033291482 no 1842 0.462855181246021 2577 768876 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.0932438393704505 0.455957765730252 no 1843 0.462854923646186 2637 6728940 SGTC_101 0490-5701 117.494 µM -0.0932637274175096 0.455949560489264 no 1844 0.462847023887336 2576 4661669 SGTC_1554 st069299 38.7 µM -0.0936058154060407 0.455808427685602 no 1845 0.462711144937577 2634 24207999 SGTC_3199 9111318 49.47 µM -0.0936860086143745 0.455775343751242 no 1846 0.462679292448935 2642 8548020 SGTC_350 k064-0020 19.8 µM -0.0937906642922682 0.455732168217313 no 1847 0.462637723904746 2628 2790705 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.0942308286148213 0.455550584853145 no 1848 0.462462898014444 2565 229346 A bile salt which induces apoptosis. SGTC_2029 5175081 200 µM -0.0942465537743421 0.455544097839756 no 1849 0.462456652378641 2562 1380876 SGTC_2047 4141938 200 µM -0.0964915600962612 0.45461810022025 no 1850 0.461565088358564 2604 3807862 SGTC_144 4161-2749 112.381 µM -0.096606544575968 0.454570679174157 no 1851 0.461519429494316 2567 797501 YMR168C CEP3 SGTC_731 3966-0296 387 µM -0.096897977883609 0.454450491313178 no 1852 0.461403707333513 2588 660956 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.0971103405130435 0.454362915033343 no 1853 0.46131938456724 2683 521171 SGTC_2216 7189485 200 µM -0.0971278990949014 0.454355674144458 no 1854 0.461312412664133 2603 731273 SGTC_1743 st037606 46.3785 µM -0.0974373223728316 0.454228075238643 no 1855 0.461189553378567 2614 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_1254 0550-0035 264 µM -0.0985261668492732 0.453779098948307 no 1856 0.460757247449701 2669 15121435 SGTC_61 0978-8327 98.565 µM -0.0990083157242599 0.453580307558568 no 1857 0.460565833777543 2592 6150059 YHR072W ERG7 SGTC_2767 sibutramine 71.45 µM -0.0994901843765693 0.45338164332555 no 1858 0.460374540483392 2648 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3039 9090270 49.47 µM -0.0996734563902799 0.453306087218016 no 1859 0.460301787154798 2598 17173750 SGTC_1939 st074455 53.6 µM -0.100667185624779 0.452896439803117 no 1860 0.459907330543932 2635 1644229 SGTC_27 0485-0001 32.618 µM -0.100751215701856 0.452861802172899 no 1861 0.459873976964692 2580 2054479 SGTC_1874 staurosporine 7.6 µM -0.100953692643411 0.452778341609468 no 1862 0.459793610107473 2672 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1947 st076332 61.6 µM -0.102329237507019 0.452211400364723 no 1863 0.45924767446869 2609 24208416 SGTC_1923 st058458 19.1 µM -0.103698692162787 0.451647066024536 no 1864 0.458704232281766 2682 3534982 SGTC_1220 1838-0075 193 µM -0.108421364090341 0.44970167118282 no 1865 0.456830727467476 2634 5529645 SGTC_588 3970-1144 52.9 µM -0.108855047236789 0.449523085361851 no 1866 0.456658730900127 2727 1888707 SGTC_1521 st012942 49.4 µM -0.109068299820377 0.449435274104101 no 1867 0.456574158967716 2846 24207259 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.109552071481219 0.449236080086719 no 1868 0.456382311595582 2596 2724278 An inhibitor of dopamine biosynthesis. SGTC_1108 betulinic acid 729.144 nM -0.111315325160687 0.448510165267373 no 1869 0.455683151605132 2616 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_2534 helenine 20.12 µM -0.111318427864208 0.448508888064958 no 1870 0.455681921450869 2607 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2374 9071832 200 µM -0.111663962352684 0.448366654973562 no 1871 0.455544927224898 2592 17381698 SGTC_206 4546-0025 72.014 µM -0.113194993420332 0.447736513524694 no 1872 0.454937982414839 2626 6620745 YIL048W NEO1 SGTC_2532 xanthone 78.9 µM -0.113526235628047 0.447600198223675 no 1873 0.454806682254699 2696 7020 An insecticide. SGTC_3214 9129694 49.47 µM -0.113963495393082 0.447420263254315 no 1874 0.454633365658439 2666 17158655 SGTC_1624 st003710 6.25 µM -0.114567740567078 0.44717163062151 no 1875 0.454393875297643 2657 24207033 SGTC_1855 st056195 39.6 µM -0.115042061541805 0.446976473270862 no 1876 0.454205891527648 2680 4028379 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.11543917696543 0.446813091688787 no 1877 0.454048513892252 2726 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1223 0764-0573 147 µM -0.116025852074858 0.446571737818361 no 1878 0.453816026583967 2628 1609797 SGTC_2816 7982706 58.44 µM -0.116623778135825 0.446325775751889 no 1879 0.453579097037835 2705 2981853 SGTC_3025 9087895 49.47 µM -0.116759039944343 0.446270137495569 no 1880 0.453525501530494 2656 17173641 SGTC_1668 st014914 51.6 µM -0.116792287311983 0.446256461767873 no 1881 0.453512327878362 2614 2839556 SGTC_3030 9087619 49.47 µM -0.117695813153773 0.445884836621403 no 1882 0.45315434217134 2635 25236973 SGTC_3264 9137442 49.47 µM -0.117783949361719 0.445848588253893 no 1883 0.453119423783521 2761 17015726 SGTC_2414 st077232 92.9 µM -0.118602875379469 0.445511804755502 no 1884 0.452794993605459 2604 729801 SGTC_1845 st056753 3.01 µM -0.118694061303503 0.445474306953111 no 1885 0.452758870840301 2574 5375839 SGTC_570 0987-0065 62.6 µM -0.120477345236194 0.444741077005264 no 1886 0.452052512399256 2606 3104428 SGTC_1122 capsaicin 818.572 nM -0.120674489436225 0.444660029104942 no 1887 0.451974432892096 2753 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2318 6029776 164 µM -0.120707796166058 0.444646336612351 no 1888 0.451961241852713 2720 818325 SGTC_2260 7964312 200 µM -0.121306062142395 0.444400399010589 no 1889 0.451724309292353 2825 231951 SGTC_1010 4112-3296 15.2 µM -0.121441439732802 0.444344750408679 no 1890 0.451670697796898 2684 704384 SGTC_1919 st067113 52.3 µM -0.122278180391788 0.444000822391761 no 1891 0.45133935591837 2744 1268243 SGTC_2539 epi(13)torulosol 80 µM -0.123668810402641 0.44342932097918 no 1892 0.450788753868426 2706 6708597 SGTC_1489 4065-0444 182 µM -0.12408539453428 0.443258141983665 no 1893 0.450623831127183 2617 2877968 SGTC_3259 9138485 49.47 µM -0.124576921525726 0.443056181763989 no 1894 0.450429249997942 2751 17646153 SGTC_2195 6536160 144.242 µM -0.125307770351292 0.442755915571878 no 1895 0.450139950411238 2634 3834386 SGTC_1713 st033146 12.748 µM -0.125437473714995 0.442702630915878 no 1896 0.450088611326676 2693 674619 SGTC_1852 st056254 31.4 µM -0.12576028174623 0.442570019620823 no 1897 0.449960841330908 2668 442583 SGTC_261 5-fluorouridine 15.376 µM -0.126689734125715 0.442188231512726 no 1898 0.449592985672548 2731 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_629 3448-6466 76.7 µM -0.126731699261177 0.442170994895736 no 1899 0.449576377866489 2655 573744 SGTC_164 4100-3994 89.624 µM -0.127061812803772 0.442035409002799 no 1900 0.449445737698737 2620 4615967 SGTC_336 4111-0029 111 µM -0.12726746228246 0.441950947047377 no 1901 0.449364356098816 2683 3131175 SGTC_1745 st081495 74 µM -0.127490135498203 0.441859496277173 no 1902 0.449276240102891 2653 13842402 YBL026W LSM2 SGTC_2967 9089538 49.85 µM -0.128949019299506 0.441260416915778 no 1903 0.448698994314505 2796 728216 SGTC_1670 st016595 4.04 µM -0.130120471240301 0.440779466430214 no 1904 0.448235557052441 2630 597879 SGTC_2914 7968218 45.32 µM -0.130181812420977 0.440754284638473 no 1905 0.448211291852727 2725 2977111 SGTC_24 0417-1663 219 µM -0.130945097363906 0.440440960845768 no 1906 0.447909369628847 2702 4329390 SGTC_3009 9080819 71.4286 µM -0.130973390017764 0.440429347600186 no 1907 0.447898178868207 2708 17027216 SGTC_2750 bromebric acid 70.15 µM -0.131035285492309 0.440403941631044 no 1908 0.447873697129854 2744 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_709 3807-1509 243 µM -0.133376192237173 0.439443260743883 no 1909 0.446947936506747 2625 1886677 YPL242C IQG1 SGTC_490 phenamil 164 µM -0.133699893849023 0.439310445300361 no 1910 0.446819944553279 2751 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1784 st039334 36.3 µM -0.134084164242245 0.439152787229796 no 1911 0.446668010832714 2880 3496984 SGTC_1174 0739-0097 51.1 µM -0.134958842844389 0.43879396099996 no 1912 0.446322207598834 2694 728447 SGTC_3268 9137683 49.47 µM -0.136227538106838 0.438273583705043 no 1913 0.445820702916873 2616 1953228 SGTC_1488 4013-0813 75.9 µM -0.138842390184035 0.437201394507295 no 1914 0.444787347924475 2653 2910057 SGTC_3181 9108277 49.47 µM -0.139130568130151 0.437083258608802 no 1915 0.444673486629085 2670 17097298 SGTC_318 1488-0629 67.2 µM -0.139493755269632 0.436934381372749 no 1916 0.444529995134912 2728 3662576 SGTC_802 4112-3352 742 µM -0.139537415572348 0.436916484794828 no 1917 0.444512745888573 2800 704594 SGTC_1917 st066507 28.5 µM -0.141635862146835 0.436056473861506 no 1918 0.44368381929009 2661 3156428 SGTC_2207 7258803 200 µM -0.141916794339655 0.435941361659907 no 1919 0.443572864310088 2736 3666799 SGTC_1081 sertraline 6 µM -0.142382702951789 0.43575046718196 no 1920 0.44338886211525 2749 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1162 k048-0130 20.1 µM -0.142469292656412 0.43571499085003 no 1921 0.443354666418563 2668 6797406 SGTC_2830 7992007 71.43 µM -0.144072928465371 0.435058065244205 no 1922 0.442721440811975 2596 1952075 SGTC_169 k015-0017 16.025 µM -0.145553374291241 0.434451763168844 no 1923 0.44213698889847 2739 1840002 SGTC_1621 st003705 32.4 µM -0.145679266339973 0.434400212405405 no 1924 0.44208729489887 2819 24207032 SGTC_1368 1852-0141 284 µM -0.146026512516476 0.434258026480956 no 1925 0.441950229400759 2792 2838987 SGTC_927 2425-1185 123 µM -0.146906213011311 0.433897856073925 no 1926 0.441603023929709 2633 730375 SGTC_764 1951-2361 146 µM -0.147058608301989 0.433835467367952 no 1927 0.441542880193968 2689 5438930 SGTC_1999 st074831 12.5 µM -0.148701063969313 0.433163171704864 no 1928 0.44089476082361 2700 17112523 SGTC_2311 7694451 200 µM -0.151215705817055 0.432134245079062 no 1929 0.439902780654198 2745 2163142 SGTC_469 w7 172 µM -0.152196957887678 0.431732866449049 no 1930 0.439515796633759 2673 45115570 A P450 inhibitor. SGTC_2255 7941087 197.44 µM -0.152472348152329 0.431620231417108 no 1931 0.43940719920008 2811 935561 SGTC_963 1269-2853 151 µM -0.152827200342316 0.431475104536461 no 1932 0.439267273464543 2709 3668223 SGTC_1480 1070-0044 41.2 µM -0.152899049707762 0.431445720823378 no 1933 0.43923894266092 2772 3124987 SGTC_2161 5662504 8.5105 µM -0.153525685383888 0.431189466282416 no 1934 0.438991868200849 2702 2859334 SGTC_745 0469-0705 296 µM -0.155066377194039 0.430559543688064 no 1935 0.438384494314295 2807 3486736 SGTC_2806 7952793 58.44 µM -0.155335698680116 0.430449447813569 no 1936 0.438278336843603 2813 2972490 SGTC_582 0987-0078 156 µM -0.156012594007086 0.430172763800364 no 1937 0.438011547098632 2692 1625765 SGTC_2483 5729050 27.16 µM -0.15613743155079 0.430121739632602 no 1938 0.43796234703076 2745 2865180 SGTC_2595 hexamethylquercetagetin 100 µM -0.156437082451453 0.429999269719392 no 1939 0.437844254704742 2784 386331 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.15645022313526 0.429993899162396 no 1940 0.437839076091998 2650 2333 A French combination drug. SGTC_835 0312-0010 67.2 µM -0.156995912021525 0.429770889244134 no 1941 0.437624034942527 2676 1626196 SGTC_1638 st008370 60.6 µM -0.158740218060221 0.42905818395664 no 1942 0.436936775236335 2657 24207134 SGTC_822 1487-0950 154 µM -0.159841916780977 0.428608160318522 no 1943 0.436502801874214 2714 1958375 SGTC_2227 7312221 64.1025 µM -0.159930053550865 0.428572162072873 no 1944 0.436468086956024 2705 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2399 5884133 200 µM -0.161149551836548 0.4280741359759 no 1945 0.435987806746122 2723 722445 SGTC_575 k072-0246 11.9 µM -0.162192828264843 0.427648167312083 no 1946 0.435577003620112 2688 6796779 SGTC_2586 curcumin 80 µM -0.162491156225142 0.427526375802603 no 1947 0.435459546019661 2803 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2381 9035592 200 µM -0.162526465075925 0.427511961525292 no 1948 0.435445644605504 2730 4749657 SGTC_1451 4152-0210 104 µM -0.164668201567087 0.42663781326812 no 1949 0.434602573366896 2819 659563 SGTC_2421 5690543 90.72 µM -0.164899906575343 0.426543264547668 no 1950 0.434511382967766 2782 3397993 SGTC_2401 5128683 200 µM -0.165396795383071 0.426340520109423 no 1951 0.434315837926688 2741 708373 SGTC_2943 9068529 45.32 µM -0.16571436553227 0.426210952857822 no 1952 0.43419087015546 2680 3270634 SGTC_612 0302-0167 22.4 µM -0.166442689969493 0.425913829728275 no 1953 0.43390429036129 2778 235821 SGTC_1373 2887-0003 58.5 µM -0.166882843421869 0.425734287585583 no 1954 0.433731116400744 2802 776948 SGTC_41 0478-0632 82.643 µM -0.169621803612311 0.424617391046705 no 1955 0.432653787113086 2719 3750424 SGTC_2249 haloperidol 116.36 µM -0.169951608199066 0.424482943561107 no 1956 0.432524096979504 2692 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_6 0844-0013 19.835 µM -0.170068371830003 0.424435346035398 no 1957 0.432478183377605 2744 1584900 SGTC_1790 st045711 43.5 µM -0.170294618955365 0.424343121795628 no 1958 0.43238922145245 2809 585119 SGTC_1963 st076565 50.3 µM -0.170391591852288 0.424303594377001 no 1959 0.432351092091806 2714 4914280 SGTC_464 bw-b 70c 158 µM -0.170872752007692 0.424107478485322 no 1960 0.43216191114142 2853 5353454 SGTC_2354 9060492 162 µM -0.170969573465424 0.424068017332383 no 1961 0.432123845080906 2847 6471895 SGTC_1405 3909-7894 12 µM -0.171302060775212 0.423932512543526 no 1962 0.431993130075546 2816 7104060 SGTC_237 nikkomycin 200 µM -0.172075942685338 0.423617152787977 no 1963 0.431688912797363 2845 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1091 telmisartan 47.6 µM -0.172966841756446 0.423254168687727 no 1964 0.431338745593965 2808 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_537 1334-0398 209 µM -0.17396785273514 0.422846398779407 no 1965 0.430945363372471 2770 5846986 SGTC_371 0195-0006 7.36 µM -0.17535203213754 0.422282678366608 no 1966 0.430401514665799 2679 3928593 SGTC_2510 benzyl isothiocyanate 8.31 µM -0.175823398661971 0.422090746074439 no 1967 0.430216343260766 2692 2346 DNA damaging agent; causes G2/M arrest. SGTC_667 1498-1044 59 µM -0.176414964857075 0.421849896741226 no 1968 0.429983974392768 2753 6739982 SGTC_47 0149-0135 24.25 µM -0.176505163226336 0.421813176084382 no 1969 0.429948546347804 2687 5239155 SGTC_3080 9117754 49.47 µM -0.177353004080332 0.421468044875868 no 1970 0.429615559686356 2916 9550191 SGTC_906 1165-0455 526 µM -0.177899706214576 0.421245530403415 no 1971 0.429400870786362 2708 3252859 SGTC_669 0108-0021 26.2 µM -0.179262750929258 0.420690864162382 no 1972 0.428865696746854 2680 17201 SGTC_3085 9117376 49.47 µM -0.179701959721767 0.420512169618425 no 1973 0.428693277427969 2796 16480349 SGTC_2642 cholecalciferol 100 µM -0.1798013507128 0.420471734111477 no 1974 0.428654261592019 2819 9821465 A vitamin D precursor, similar to steriods. SGTC_3143 9086658 49.47 µM -0.183701971322256 0.418885500944353 no 1975 0.427123631168966 2819 25236626 SGTC_1649 st011737 51.3 µM -0.184082697578076 0.418730744318434 no 1976 0.426974289928208 2769 1761035 SGTC_319 1348-1596 45.5 µM -0.184941416756463 0.418381740569523 no 1977 0.426637492704517 2928 5380505 SGTC_368 fentichlor 4.58 µM -0.185235688359445 0.41826215640861 no 1978 0.426522089082788 2814 7329 A pesticide. SGTC_3156 9099931 49.47 µM -0.185296384080574 0.418237492219677 no 1979 0.426498287004068 2731 18111053 SGTC_1704 st028805 70.8 µM -0.185339236036132 0.418220079180394 no 1980 0.426481482593216 2790 2876101 SGTC_331 k048-0133 24.5 µM -0.185777663158672 0.418041932028854 no 1981 0.426309560901782 2731 6813582 SGTC_3055 9094636 49.47 µM -0.186046371805492 0.417932755303804 no 1982 0.426204198324367 2895 25236176 SGTC_3119 9125183 49.47 µM -0.18613423261609 0.417897058696653 no 1983 0.426169748616045 2811 22695334 SGTC_1173 0443-0020 122 µM -0.186256153254398 0.417847525182905 no 1984 0.426121945182488 2749 5331295 SGTC_1646 st011709 75.6 µM -0.187170144554528 0.417476233378831 no 1985 0.425763616172681 2780 5757843 SGTC_392 N-ethylmaleimide 8.33 µM -0.187404286330231 0.417381129502435 no 1986 0.425671831068098 2788 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1720 st037298 9.481 µM -0.18741295306741 0.417377609333563 no 1987 0.425668433727812 2823 597396 SGTC_1997 st073024 93.8 µM -0.187440343034878 0.417366484393278 no 1988 0.425657696962223 2760 686268 SGTC_1500 4488-1866 171 µM -0.188307033749388 0.417014496188256 no 1989 0.425317985927736 2889 2900003 SGTC_2012 4023501 200 µM -0.188635604596327 0.416881071420356 no 1990 0.425189212662246 2807 3477460 SGTC_2340 7987427 183.45 µM -0.19042374336146 0.416155119210911 no 1991 0.424488546774171 2859 2239331 SGTC_1825 st052143 62.6 µM -0.191359845021204 0.415775192632117 no 1992 0.424121838853582 2893 674173 SGTC_2667 digitoxin 100 µM -0.191388422958677 0.415763595215806 no 1993 0.424110644780599 2826 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1436 4092-1007 8.32 µM -0.192330303164674 0.415381405216358 no 1994 0.423741741491609 2750 2881121 SGTC_439 amiodarone 34.4 µM -0.192703658613907 0.415229929613729 no 1995 0.4235955290008 2807 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_2371 9071574 200 µM -0.192744678810769 0.415213287905665 no 1996 0.423579465418902 2760 45596039 SGTC_1348 1493-0373 93.8 µM -0.194512415748015 0.414496269946869 no 1997 0.422887337511869 2822 3010129 SGTC_17 0960-0276 49.807 µM -0.194817189165987 0.414372678455376 no 1998 0.422768032554858 2736 6821114 SGTC_2671 danthron 100 µM -0.19842691366436 0.412909513721894 no 1999 0.421355531003274 2793 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1332 1480-0653 17.5 µM -0.200400080158249 0.412110220720379 no 2000 0.420583848401206 2744 5749438 SGTC_1319 1306-0155 43.7 µM -0.200977731829593 0.411876293602133 no 2001 0.420357993112837 2763 3122360 SGTC_1039 k821-0043 94 µM -0.202034797865151 0.411448302902745 no 2002 0.419944760156374 2930 15992768 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.202342668951273 0.411323670155155 no 2003 0.419824422395272 2830 75037 A free radical scavenger. SGTC_3226 9131256 49.47 µM -0.203917190772243 0.410686410485607 no 2004 0.419209105517829 2760 17178073 SGTC_3118 9124250 49.47 µM -0.204184621880026 0.410578195876468 no 2005 0.419104614086633 2837 1504786 SGTC_3238 9133470 49.47 µM -0.204730590303183 0.410357293730878 no 2006 0.418891309497625 2913 3534688 SGTC_1463 k081-0032 34.1 µM -0.205438750749647 0.410070810080661 no 2007 0.418614673577726 2837 977755 SGTC_1446 4239-0190 62 µM -0.20630066142998 0.409722192116395 no 2008 0.418278030950141 2784 1340085 SGTC_1688 st021091 57.6 µM -0.206435311816567 0.409667736363821 no 2009 0.418225444983859 2793 3656366 SGTC_2610 ononetin 44.17 µM -0.207294461008964 0.409320317492871 no 2010 0.417889949838939 2842 259632 SGTC_658 3253-0951 102 µM -0.20859923872336 0.408792833644132 no 2011 0.417380552456408 2822 1184878 SGTC_579 4491-1009 110 µM -0.208838900602844 0.408695963212121 no 2012 0.417287001270067 2811 1271041 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.208954014695042 0.408649436510752 no 2013 0.417242068546292 2912 61125 An anti-inflammatory. SGTC_845 0330-0138 4.51 µM -0.209296927550453 0.408510845959942 no 2014 0.417108225063311 2864 9039800 SGTC_546 peri-Naphthalide 147 µM -0.211035029192526 0.407808556731168 no 2015 0.416429968747398 2860 223824 A penicillin ester. SGTC_2499 avocadenofuran 51.48 µM -0.212812691893339 0.407090588956077 no 2016 0.41573653190091 2773 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_373 0844-0104 25.9 µM -0.214980512249213 0.40621546567321 no 2017 0.414891256156222 2895 5375804 SGTC_142 0335-0849 62.6745 µM -0.216109253707897 0.405759991300432 no 2018 0.414451293366055 2803 3889043 YPR107C YTH1 SGTC_2612 dictamnine 15.46 µM -0.21709717167743 0.405361447248333 no 2019 0.414066309040862 2892 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_2276 7947513 42.08 µM -0.22191218370439 0.403420395565316 no 2020 0.412191122883126 2877 2105100 SGTC_1978 st071761 42 µM -0.222407665365563 0.403220788593872 no 2021 0.411998272574813 2823 5147680 SGTC_1071 trifluoperazine 6.31 µM -0.222555113153761 0.403161393468019 no 2022 0.411940887364134 2961 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_470 aa-861 153 µM -0.224551349659339 0.402357487075704 no 2023 0.411164157810438 2821 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_428 3448-4153 16.5 µM -0.226400562118766 0.401613157084002 no 2024 0.410444945386232 2748 3834874 SGTC_1641 st009299 47.1 µM -0.226480498001441 0.401580989967195 no 2025 0.410413862771331 2814 4046054 SGTC_2991 9074669 71.4286 µM -0.226819860057938 0.401444434207828 no 2026 0.410281910026981 3002 17333109 SGTC_2546 rhodinyl acetate 100 µM -0.226908998710979 0.401408567736805 no 2027 0.410247252296986 2876 6708682 SGTC_419 nsc-638432 893 µM -0.229394769464056 0.400408710706309 no 2028 0.409281050575068 2893 368090 SGTC_246 cycloheximide 667 µM -0.230315444057334 0.400038550931798 no 2029 0.408923330272536 2803 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_1666 st014829 29 µM -0.230547247996695 0.399945367652031 no 2030 0.40883327675909 2779 3858230 SGTC_339 3091-4833 71.4 µM -0.231596179292044 0.399523777178201 no 2031 0.408425837662273 2829 3240077 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.231659359895109 0.399498387124001 no 2032 0.408401299412991 2797 442882 SGTC_2290 7904846 200 µM -0.232003623137994 0.399360047349006 no 2033 0.408267599859086 2896 2962154 SGTC_676 falcarinol 140 µM -0.232732854940922 0.399067052404288 no 2034 0.407984427543347 2988 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1179 1021-1431 9.29 µM -0.232764136319429 0.399054485262873 no 2035 0.407972281560075 2890 2840958 SGTC_116 0155-0182 31.788 µM -0.235998453260035 0.397755681161151 no 2036 0.406716935200524 2840 771486 SGTC_1491 4138-0063 26.5 µM -0.236390692091126 0.397598246591868 no 2037 0.406564759094887 2812 23883227 SGTC_2899 9053889 58.44 µM -0.236644916341292 0.3974962164284 no 2038 0.406466135761496 2894 6470052 SGTC_1838 st055369 84.5 µM -0.237021991176029 0.397344894422842 no 2039 0.406319864904604 2797 676036 SGTC_112 phenothiazine 287.218 µM -0.237626866158622 0.397102187362883 no 2040 0.406085255550844 2840 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1931 st074438 57.1 µM -0.238152986757554 0.396891113022793 no 2041 0.405881219620116 2767 2787313 SGTC_607 4491-0986 66.8 µM -0.238951194188617 0.396570937848038 no 2042 0.405571713955581 2965 698981 YDR232W HEM1 SGTC_1518 st038567 90.8 µM -0.239417675572485 0.396383856149226 no 2043 0.405390862686655 2794 77966 SGTC_3171 9103192 49.47 µM -0.240746661977283 0.395850998961093 no 2044 0.404875735671009 2886 13018434 SGTC_214 4373-3496 70 µM -0.240774650878878 0.395839778897768 no 2045 0.40486488869123 2869 3779166 SGTC_102 gallobenzophenone 83.616 µM -0.241991025008722 0.39535224787978 no 2046 0.404393558797911 3007 70837 SGTC_692 k241-0027 77.8 µM -0.242509450141017 0.39514450928446 no 2047 0.404192717608803 3001 3600480 SGTC_3168 9103419 49.47 µM -0.244271779900599 0.394438547719031 no 2048 0.403510168970778 2854 16649256 SGTC_2916 7875993 68.79 µM -0.246634478127284 0.393492632137296 no 2049 0.40259555947806 2854 1299250 SGTC_3325 9138760 55.175 µM -0.249310619652077 0.392421987301297 no 2050 0.401560258668446 2883 43844959 SGTC_2417 cerulenin 830 nM -0.250637271953218 0.391891534233251 no 2051 0.40104728121566 2900 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2035 5154463 94.595 µM -0.250986327358386 0.391752000101302 no 2052 0.400912340053676 2973 2769623 SGTC_3050 9093513 49.47 µM -0.251999027836358 0.391347254166122 no 2053 0.400520907616748 2852 25236664 SGTC_2095 5432005 200 µM -0.25207217946837 0.391318022207759 no 2054 0.400492636662342 2858 783734 SGTC_1824 st053723 68.6 µM -0.253039501290586 0.390931530706996 no 2055 0.400118844305024 2906 675225 SGTC_294 k038-0071 157 µM -0.254561913540474 0.390323472208049 no 2056 0.399530739401534 2892 24152826 SGTC_1211 1056-0033 32.3 µM -0.256301750220494 0.389628901825372 no 2057 0.398858922950901 2969 6741922 SGTC_1056 3448-1962 115 µM -0.256993845651854 0.389352704197654 no 2058 0.398591762009187 2952 715507 SGTC_1900 st060200 72.8 µM -0.257695532763858 0.389072735828989 no 2059 0.398320947018004 2834 688945 SGTC_1314 1222-0010 41.1 µM -0.257750184365859 0.389050932628148 no 2060 0.398299856375502 2905 3526027 SGTC_3240 9133527 49.47 µM -0.257981167939942 0.388958785826597 no 2061 0.398210720605642 2892 17617455 SGTC_2194 5927483 104.545 µM -0.25801532343506 0.388945160627352 no 2062 0.398197540567755 2853 760979 SGTC_1377 2944-0135 198 µM -0.258314781186994 0.388825707763063 no 2063 0.398081989773336 2942 1894137 SGTC_3029 9088683 49.47 µM -0.259283496743314 0.388439361866122 no 2064 0.397708255906388 3019 25236615 SGTC_308 4092-1169 104 µM -0.259863258445858 0.388208192410061 no 2065 0.397484626678905 2879 2268590 YDL196W YDL196W SGTC_2817 7995342 71.43 µM -0.259985513043753 0.388159450661184 no 2066 0.397437474186857 2826 18879975 SGTC_2475 5812728 15.03 µM -0.260209345650246 0.388070215289182 no 2067 0.397351147860442 2836 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_507 nimesulide 162 µM -0.261921184247734 0.387387952135909 no 2068 0.396691103469458 3059 4495 A COX2 inhibitor. SGTC_1338 1486-1223 76 µM -0.26342670325982 0.386788206087447 no 2069 0.396110855494751 2942 3444526 SGTC_875 0709-0210 25.7 µM -0.263606937302265 0.386716425242694 no 2070 0.39604140618361 2928 6251364 SGTC_896 0964-0007 44.5 µM -0.26426342081195 0.38645500386035 no 2071 0.395788472297307 2917 6756758 SGTC_531 3788-1495 174 µM -0.265481210259756 0.385970198730052 no 2072 0.395319391371273 2836 2896655 SGTC_2357 9067248 200 µM -0.265705634456748 0.385880874281493 no 2073 0.395232961830072 2955 9150235 SGTC_3144 9087057 49.47 µM -0.266560959971674 0.385540496445855 no 2074 0.394903608841822 2946 17249618 SGTC_919 tnp00227 403.569 nM -0.267439745852983 0.385190874319 no 2075 0.394565300370209 2903 1269246 A methoxyflavone. YNL221C POP1 SGTC_475 α-linolenic acid 10 µM -0.26760068044706 0.385126857109609 no 2076 0.394503353569226 3110 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_3133 9127736 49.47 µM -0.267986543593358 0.384973379671651 no 2077 0.39435483833876 2983 27243420 SGTC_941 3237-0776 460 µM -0.269382001675985 0.38441848546024 no 2078 0.393817867500923 3077 760008 SGTC_899 1083-0020 478 µM -0.272408658358003 0.38321577147794 no 2079 0.392653907973737 3062 767123 SGTC_1860 st056228 74.6 µM -0.274079140656621 0.382552446558403 no 2080 0.392011901806341 2996 688679 SGTC_196 k015-0023 18.111 µM -0.275126632346837 0.382136677979744 no 2081 0.391609475588363 2880 5211998 SGTC_1420 4'-methoxyflavone 42 µM -0.276350270545564 0.381651165727673 no 2082 0.391139524137914 2968 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_126 0417-1624 672.48 µM -0.278450568070866 0.38081824897599 no 2083 0.390333252993649 2990 41912 YDL195W SEC31 SGTC_651 3253-0966 34.4 µM -0.279862544794644 0.380258610222329 no 2084 0.38979148214041 2903 781462 SGTC_829 1635-0120 117 µM -0.284263267344648 0.37851599062937 no 2085 0.388104316937298 3042 285054 SGTC_2445 5742597 35.57 µM -0.28524503313071 0.378127561622538 no 2086 0.387728210666073 2903 1774255 SGTC_2383 9036125 200 µM -0.286391836971185 0.377673992387973 no 2087 0.387289013072778 2914 79580 SGTC_67 0335-0847 266 µM -0.287111549357757 0.377389426997124 no 2088 0.387013454599761 3245 4552207 YOR254C SEC63 SGTC_975 1335-0046 28.5 µM -0.287699873475667 0.377156860336679 no 2089 0.386788243440196 2940 16486740 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.288134837673065 0.37698494604991 no 2090 0.386621763140777 3028 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_508 roscovitine 141 µM -0.288160911785927 0.376974641349575 no 2091 0.386611784071315 2907 160355 A CDKinase inhibitor. SGTC_3066 9117245 49.47 µM -0.289594427030958 0.376408239558693 no 2092 0.386063265490695 2960 17176980 SGTC_635 k038-0028 24.7 µM -0.290169218191186 0.376181206233006 no 2093 0.385843391965874 2951 4035102 SGTC_467 ro 31-8220 72.8 µM -0.290605309053406 0.37600898588567 no 2094 0.38567659960357 2964 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3052 9092717 49.47 µM -0.290998758783506 0.375853626496676 no 2095 0.385526134399025 3086 25237534 SGTC_2427 5545055 42.75 µM -0.291713730951684 0.375571360785225 no 2096 0.38525275492824 2941 5372858 SGTC_1979 st071809 45.3 µM -0.293661611611967 0.374802690171085 no 2097 0.384508245507799 3053 4976333 SGTC_2187 6125751 200 µM -0.293715583371411 0.374781398956342 no 2098 0.384487622735698 2953 874498 SGTC_879 0831-1030 162 µM -0.294364848429911 0.37452530157223 no 2099 0.384239562235103 2945 1549252 SGTC_1617 st002906 78 µM -0.295943862972025 0.373902703132315 no 2100 0.383636476390557 2903 5150859 SGTC_174 3553-0389 74.3 µM -0.296126330024202 0.373830778347289 no 2101 0.383566803402485 3063 738071 SGTC_2687 chenodiol 100 µM -0.296156712564037 0.373818802597252 no 2102 0.383555202537508 3021 5702181 A cholesterol synthesis inhibitor. SGTC_569 4130-2812 160 µM -0.297059818245924 0.373462885135496 no 2103 0.383210420381745 2926 743552 SGTC_3191 9110352 49.47 µM -0.299419331900739 0.372533501605721 no 2104 0.382310056826796 2939 17122424 SGTC_1647 st011722 22.4 µM -0.301199527321678 0.37183279499969 no 2105 0.381631175120937 3094 2854783 SGTC_2172 5754775 163.918 µM -0.303545233753956 0.370910144602102 no 2106 0.380737190460938 2926 2263357 SGTC_1222 0366-0074 1.18 µM -0.305163690875829 0.37027397947835 no 2107 0.380120742364169 3062 286520 SGTC_2958 9077254 16.72 µM -0.305451027166173 0.370161073549622 no 2108 0.380011331691119 3141 16457351 SGTC_1160 4092-0570 10.5 µM -0.305780110341996 0.37003177734257 no 2109 0.379886036615847 2938 4994975 SGTC_568 1193-0097 7.48 µM -0.30723010706237 0.369462251269686 no 2110 0.37933411542262 3044 3646150 SGTC_2627 acetyl isogambogic acid 100 µM -0.307952154976346 0.369178753811603 no 2111 0.379059369488494 3028 6857789 A caspase activator and apoptosis inducer. SGTC_1995 st072814 61.1 µM -0.308549626483758 0.368944222530092 no 2112 0.378832072213125 2954 5769371 SGTC_817 1391-0715 46 µM -0.308993505734143 0.368770013888448 no 2113 0.378663233468398 2985 1353946 SGTC_2653 dihydrofissinolide 100 µM -0.309760231210019 0.368469161785621 no 2114 0.378371647978312 3019 6857746 SGTC_517 1365-0151 113 µM -0.310003207628965 0.368373838129444 no 2115 0.378279258553519 3119 768657 SGTC_749 1000-0129 128 µM -0.310567491535961 0.368152491509438 no 2116 0.378064721930224 3111 708470 SGTC_3277 9138724 49.47 µM -0.311675940084829 0.367717817746398 no 2117 0.377643407393677 2991 15943418 SGTC_3116 9124943 49.47 µM -0.311707807326857 0.367705323634252 no 2118 0.377631296999082 2969 41905195 YPL160W CDC60 SGTC_2924 9010168 62.78 µM -0.313105332904032 0.367157537044396 no 2119 0.377100318798019 3049 2993929 SGTC_529 4076-0302 30.3 µM -0.314050145010565 0.366787353130391 no 2120 0.37674147685811 2973 5816522 SGTC_2257 7960413 200 µM -0.315651991732086 0.366160021666045 no 2121 0.376133334974189 2948 2974689 YIL048W NEO1 SGTC_484 loperamide 105 µM -0.315887388604415 0.366067863248946 no 2122 0.376043992311076 2942 3955 An opioid-receptor agonist. SGTC_3160 9100216 49.47 µM -0.315993886800393 0.366026171498288 no 2123 0.376003574107424 2930 17191039 SGTC_234 nsc-17383 10.7 µM -0.316100877245709 0.365984288635432 no 2124 0.375962970454873 3116 408974 SGTC_2199 6590217 200 µM -0.316890882405193 0.365675079846916 no 2125 0.375663200279536 3010 703109 SGTC_138 0850-0259 40.9225 µM -0.317169564906773 0.365566024053528 no 2126 0.375557471140763 3045 6813004 SGTC_814 3342-0569 96 µM -0.31784144611337 0.365303143956988 no 2127 0.37530260508749 2985 4346283 SGTC_1046 2001-0062 216 µM -0.319988707593813 0.364463431668716 no 2128 0.374488445451072 2949 739778 SGTC_2541 muurolladie-3-one 83.07 µM -0.320463234824728 0.364277949674026 no 2129 0.37430859815654 3131 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_3303 9125618 40.5795 µM -0.320996716816495 0.364069461542994 no 2130 0.374106439480752 3046 22695467 SGTC_45 0kpi-0036 14.9 µM -0.324452671254267 0.36271982953507 no 2131 0.372797674310887 3119 2795021 SGTC_2748 diazoxide 86.69 µM -0.324819566879405 0.362576647858355 no 2132 0.372658817319536 3048 3019 A potassium channel activatior. SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.324893886754783 0.362547646733427 no 2133 0.372630691895485 3023 688761 SGTC_2915 7971052 15.16 µM -0.325951077557249 0.362135194880552 no 2134 0.372230684909465 3041 5741558 SGTC_2212 7123476 200 µM -0.326655719741765 0.361860375000885 no 2135 0.371964147494238 2999 1085715 SGTC_3229 9132204 49.47 µM -0.326900085340224 0.361765085772803 no 2136 0.371871728268847 2979 17682924 SGTC_918 glabranin 770.725 nM -0.327254678950907 0.361626828886893 no 2137 0.37173763386875 3021 124049 Also referred to as licorice root. SGTC_2348 9022543 33.42 µM -0.327562606576899 0.361506781831303 no 2138 0.37162119946827 3103 3162678 YDL140C RPO21 SGTC_1107 amlodipine 47 µM -0.328624801158509 0.361092784883365 no 2139 0.371219649856237 3051 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_1354 1498-1681 81 µM -0.328886644534486 0.360990754770467 no 2140 0.371120684700593 3081 5754243 SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.329339436131264 0.360814342954197 no 2141 0.370949569720135 2989 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2016 5121758 140 µM -0.330260665645337 0.360455514810265 no 2142 0.370601505638777 2927 2795203 SGTC_803 4488-1585 147 µM -0.332534661195929 0.359570297230193 no 2143 0.369742785743048 3115 747204 SGTC_1416 3966-0321 25.3 µM -0.332627811104223 0.359534051996074 no 2144 0.369707623725971 3045 582530 YLR208W SEC13 SGTC_2580 diallyl disulphide 81.36 µM -0.335792536718171 0.358303389393964 no 2145 0.368513659284033 2974 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1631 benzylvanillin 81.9 µM -0.336157991823735 0.35816136982559 no 2146 0.368375864540227 3135 75506 SGTC_1968 st069590 43.6 µM -0.336724103753562 0.357941411723788 no 2147 0.368162445623336 3122 6384066 SGTC_837 0091-0265 12.5 µM -0.337829839021593 0.357511923497031 no 2148 0.367745711119519 3000 759367 SGTC_74 000s-0487 160.283 µM -0.337912154811374 0.357479957715031 no 2149 0.367714693791802 3010 677548 SGTC_3279 9140807 49.47 µM -0.339358618568537 0.356918414176509 no 2150 0.367169794225526 3020 45595718 SGTC_485 niflumic acid 177 µM -0.340783792763009 0.356365438661864 no 2151 0.366633176212384 3118 4488 A COX2 inhibitor. SGTC_880 0833-0487 87.2 µM -0.342951770113343 0.355524830555737 no 2152 0.365817371976568 2997 76075 SGTC_1498 4478-3555 97.6 µM -0.343845423915023 0.355178530807252 no 2153 0.365481268663201 3078 3437919 SGTC_714 4296-0578 26.1 µM -0.344412100190632 0.354959000038071 no 2154 0.365268195126096 3000 1589775 SGTC_1914 st062367 72.6 µM -0.344543823425243 0.354907977262276 no 2155 0.365218672386642 3000 978205 SGTC_97 0535-0701 19.132 µM -0.344621223667519 0.354877997620851 no 2156 0.365189573997416 3041 2832013 YGL099W LSG1 SGTC_1249 0481-0015 10.2 µM -0.345372838436797 0.354586919432688 no 2157 0.364907047063274 2980 4227577 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.345858204701045 0.354398996522315 no 2158 0.364724640108944 3025 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_3243 9134147 49.47 µM -0.347002438924509 0.353956115079695 no 2159 0.364294743245859 3090 24282180 SGTC_768 0384-0033 77.3 µM -0.347278641386258 0.353849239140409 no 2160 0.364190997584444 3027 3965305 YMR134W ERG29 SGTC_2872 9044037 25.97 µM -0.347763886753584 0.353661502398181 no 2161 0.364008756469314 3001 6465195 SGTC_1324 1418-0026 34.4 µM -0.348613368462034 0.35333293183852 no 2162 0.363689795038506 3121 1372513 SGTC_2462 5162487 171.77 µM -0.349012021160114 0.35317877484371 no 2163 0.363540142391829 3031 2259986 SGTC_3274 9138298 49.47 µM -0.349015477953266 0.353177438224486 no 2164 0.363538844816369 2977 17015756 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.351051014002168 0.352390683745513 no 2165 0.362775038567121 3085 66535 A nucleotide analog. SGTC_2621 lithochol-11-enic acid 100 µM -0.353762070361215 0.351343814598243 no 2166 0.36175860055309 3144 6708711 SGTC_710 3448-4187 58 µM -0.354793517075524 0.350945818910889 no 2167 0.361372142735265 3065 3946412 SGTC_1403 3909-7815 62.9 µM -0.355595721688796 0.350636391933986 no 2168 0.361071674050342 2997 6615483 SGTC_173 1273-0061 2.693 µM -0.355729243943836 0.35058489923894 no 2169 0.361021671113843 3125 2847414 YPL266W DIM1 SGTC_131 0141-0277 33.849 µM -0.356693458318885 0.350213132682367 no 2170 0.360660651669157 3203 1547771 SGTC_2226 7298446 200 µM -0.358442934249945 0.349538963921745 no 2171 0.360005933149572 3135 3283010 SGTC_1382 3002-2117 298 µM -0.358730966601048 0.349428014718932 no 2172 0.359898180106848 3190 1497314 SGTC_2983 9022671 12.99 µM -0.361034044743881 0.348541339220382 no 2173 0.359036998510401 3231 6405161 SGTC_389 tpck 16.7 µM -0.361233684696016 0.348464517545661 no 2174 0.358962381527356 3101 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_951 1171-0579 82.7 µM -0.362681858403662 0.347907444927647 no 2175 0.35842127660245 2998 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2396 5342950 42.78 µM -0.36375566373009 0.347494593310518 no 2176 0.358020236475613 3131 1886677 SGTC_616 4092-0450 108 µM -0.364612336505448 0.347165353449439 no 2177 0.357700402361731 3096 787165 SGTC_1132 3456-3614 2.5 µM -0.364918606845203 0.347047674394482 no 2178 0.357586082226799 3279 3125502 SGTC_738 1315-0003 72.4 µM -0.366422364099061 0.346470095977204 no 2179 0.357024967143348 3187 6251474 SGTC_384 k007-0144 5.16 µM -0.366472128168733 0.346450988177585 no 2180 0.357006403353411 3097 6824886 SGTC_2116 5511452 16.8835 µM -0.367871453732281 0.345913852366996 no 2181 0.356484543279985 3174 870744 SGTC_2313 7726885 200 µM -0.368918100423875 0.345512296060519 no 2182 0.356094385673359 3135 726423 SGTC_374 0880-0231 82.3 µM -0.369083787631424 0.34544874445433 no 2183 0.356032636392068 3108 6833587 SGTC_3348 9149464 3.537 µM -0.370123240296807 0.345050147554744 no 2184 0.355645333280893 3067 1951442 SGTC_2282 7944268 200 µM -0.37113275260652 0.344663196321586 no 2185 0.355269328632583 3257 2970414 SGTC_2649 anisomycin 9.56 µM -0.371418934612183 0.344553530833652 no 2186 0.355162762412187 3120 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2076 5212012 200 µM -0.371580225149631 0.344491729749023 no 2187 0.355102707291654 3067 604802 SGTC_1275 0867-0008 21.1 µM -0.37183672992542 0.344393454335689 no 2188 0.355007207396293 3016 3422836 SGTC_1818 st052136 56.3 µM -0.372174994935146 0.344263869949759 no 2189 0.354881281082771 3162 674169 SGTC_703 3875-0075 71.8 µM -0.373068270661458 0.343921756980376 no 2190 0.354548816513832 3072 2850814 SGTC_648 0375-0473 33.3 µM -0.374961738465617 0.343197006121313 no 2191 0.353844461175803 3065 1713139 SGTC_2128 5255449 168.493 µM -0.377447664318606 0.342246359133658 no 2192 0.352920475376441 3066 736008 SGTC_1410 3909-8106 77.9 µM -0.377505298629907 0.342224330926461 no 2193 0.352899063723746 3161 1039210 SGTC_1326 1431-2094 10.8 µM -0.379398409076437 0.341501070666399 no 2194 0.352196015891112 2998 616278 SGTC_787 4152-0075 138 µM -0.379595730502899 0.341425717712419 no 2195 0.352122765289724 3106 9566539 SGTC_990 3985-0011 41.3 µM -0.380149645399118 0.341214222904697 no 2196 0.351917167684793 3107 5399565 YGL099W LSG1 SGTC_1194 1488-0194 225 µM -0.380727995225448 0.340993451612381 no 2197 0.35170254671775 3045 1391452 SGTC_3316 9136639 10.545 µM -0.381144104587362 0.340834645424391 no 2198 0.351548161107019 3179 4903665 SGTC_3321 9137793 26.8275 µM -0.382341055802873 0.340377991922535 no 2199 0.35110420279502 3152 4904192 SGTC_902 1120-0002 2.07 µM -0.3824087170431 0.340352185200477 no 2200 0.35107911278692 3073 3280475 SGTC_2225 6654152 15.4 µM -0.382433745586687 0.340342639235177 no 2201 0.351069831916063 3133 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1794 st048918 76.9 µM -0.382954623919388 0.340143997827237 no 2202 0.350876704428989 3140 672303 SGTC_96 0929-0093 37.281 µM -0.384526689792119 0.339544746224706 no 2203 0.350294059005112 3083 6991579 SGTC_2308 7584454 197.62 µM -0.384823019016598 0.339431834645851 no 2204 0.350184271670482 3267 893577 SGTC_432 NS 1619 61.3 µM -0.385212130968849 0.339283591561226 no 2205 0.350040128176111 3230 4552 A K+/calcium channel activator. SGTC_872 0588-0139 234 µM -0.385231238671336 0.339276312587865 no 2206 0.350033050432776 3088 2047100 SGTC_2196 6573537 42.6665 µM -0.385237072217717 0.339274090342652 no 2207 0.35003088962115 3198 2903087 SGTC_1253 0550-0034 176 µM -0.385245659757312 0.339270818994803 no 2208 0.350027708708095 3195 5969915 SGTC_1371 2421-0008 32.7 µM -0.385253394673612 0.339267872456686 no 2209 0.350024843624491 3087 2827552 SGTC_1952 st077036 64.1 µM -0.387249537519476 0.338507791049478 no 2210 0.34928573991524 3107 2937007 SGTC_599 1935-0052 86.5 µM -0.388738415362681 0.337941291327799 no 2211 0.348734830874449 3068 9557311 SGTC_1673 st016611 27.3 µM -0.388941227949515 0.337864151991766 no 2212 0.348659811560708 3250 5226799 SGTC_2122 5258151 111.688 µM -0.389418996483343 0.337682460664244 no 2213 0.348483110875838 3100 2173356 SGTC_3234 9132280 49.47 µM -0.397523185002759 0.33460629850432 no 2214 0.345490846451098 3168 17612295 SGTC_3046 9092212 49.47 µM -0.398655930130667 0.334177211784121 no 2215 0.345073372121544 3167 25236637 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.399747445066798 0.333763948083141 no 2216 0.344671271527478 3190 279621 SGTC_1763 st044482 94.5 µM -0.400719629167037 0.33339603449964 no 2217 0.344313278617501 3211 88505 SGTC_779 1360-0071 233 µM -0.401176436331705 0.333223215591865 no 2218 0.344145114038008 3295 7566 SGTC_2178 5812956 200 µM -0.402356252198174 0.332777032504334 no 2219 0.343710930657589 3080 5403383 SGTC_91 0417-1751 58.384 µM -0.402796661696468 0.332610538960585 no 2220 0.343548908592499 3198 6795624 SGTC_747 3448-8087 38.7 µM -0.403748580139588 0.332250786079285 no 2221 0.343198805943647 3140 5168703 SGTC_2092 5303694 80.6725 µM -0.40459517894349 0.331930965827056 no 2222 0.342887551444438 3123 1963699 SGTC_3146 9095609 49.47 µM -0.40472278715041 0.331882769792222 no 2223 0.342840645157968 3152 17173999 SGTC_2715 st079500 56.4 µM -0.40543716745844 0.331613008620761 no 2224 0.342578097657494 3076 28246688 SGTC_961 1252-1571 372 µM -0.406110186504228 0.331358945975159 no 2225 0.342330820712911 3288 6813498 SGTC_3079 9117512 49.47 µM -0.407390396809809 0.330875884721798 no 2226 0.341860639511851 3173 7185044 SGTC_2431 5490079 200 µM -0.407393903597678 0.330874561893101 no 2227 0.341859351914754 3175 5722345 SGTC_3074 9116018 49.47 µM -0.407459335810552 0.330849879975088 no 2228 0.341835327323767 3085 17027303 SGTC_2867 9039098 71.43 µM -0.408129066406427 0.330597290807752 no 2229 0.341589460768177 3082 6463460 SGTC_671 0560-0003 407 µM -0.409172406412633 0.330203948410429 no 2230 0.34120657139392 3119 3238678 SGTC_2304 7443016 91.4 µM -0.41037344305893 0.329751386148582 no 2231 0.340766012195001 3099 939854 SGTC_1026 k007-1105 30.6 µM -0.411111784956237 0.329473295368402 no 2232 0.340495284447744 3138 7066794 SGTC_2847 9005661 71.43 µM -0.411161995473954 0.32945438738645 no 2233 0.340476876744778 3194 2991449 SGTC_347 4534-1311 26.2 µM -0.412005998468298 0.329136622995096 no 2234 0.340167513297265 3130 2862016 SGTC_412 gemfibrozil 100 µM -0.412168479194969 0.329075463687173 no 2235 0.340107969453613 3199 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_3087 9117406 49.47 µM -0.412175906545071 0.329072668070506 no 2236 0.34010524766932 3227 42546093 SGTC_970 1315-0089 19.5 µM -0.413249002757164 0.328668860667758 no 2237 0.339712094591537 3207 6811083 YLR033W RSC58 SGTC_187 1488-2104 32.728 µM -0.413419417531323 0.328604751770285 no 2238 0.339649675311999 3206 2852859 SGTC_1393 3470-5649 58.2 µM -0.414572233802031 0.32817120257067 no 2239 0.339227538986641 3177 4108395 SGTC_1843 st055809 45.5 µM -0.414612428106069 0.32815609053533 no 2240 0.339212824340097 3247 16413835 SGTC_2423 st077119 87.2 µM -0.414653183346049 0.328140767889523 no 2241 0.339197904592093 3182 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_3014 9081533 49.47 µM -0.415631110045039 0.327773186001296 no 2242 0.338839979168701 3253 21367265 SGTC_1683 st010134 710 nM -0.416983368771662 0.327265175515645 no 2243 0.338345286277033 3099 3818134 SGTC_2581 avocatin a 64 µM -0.418221355131956 0.326800374702707 no 2244 0.337892641806821 3156 6710728 A skin care supplement. SGTC_2526 patulin 37.61 µM -0.418339575227817 0.326756003119444 no 2245 0.337849429285493 3270 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2298 7976326 193.81 µM -0.419154462756361 0.326450217820837 no 2246 0.337551624850413 3153 2235818 SGTC_3244 9134489 49.47 µM -0.420534278601137 0.325932709960593 no 2247 0.337047596721885 3198 16584271 SGTC_92 0063-0024 660.874 µM -0.420552947707782 0.325925710300681 no 2248 0.337040779151852 3189 3594437 SGTC_2400 5203494 178.7 µM -0.420802570010714 0.325832124613566 no 2249 0.336949627414304 3183 6777674 SGTC_2776 terbinafine 19.92 µM -0.421544170629013 0.325554156495223 no 2250 0.336678882042433 3213 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3285 9112818 20.8695 µM -0.422376803844408 0.325242182945616 no 2251 0.336375003118905 3142 17017947 YPR165W RHO1 SGTC_2846 9008642 19.48 µM -0.422673919009217 0.325130888561449 no 2252 0.336266593432045 3243 2992898 SGTC_1736 st036774 51 µM -0.423954634697371 0.324651332473646 no 2253 0.335799449108353 3363 1272247 SGTC_3177 9107506 49.47 µM -0.4244316212295 0.324472802020319 no 2254 0.335625531823796 3225 8897194 SGTC_452 diindolylmethane 8 µM -0.425672979638221 0.324008365308427 no 2255 0.335173076858026 3232 3071 Inhibits expression of several cancer promoting factors. SGTC_2528 xanthyletin 44.79 µM -0.426879464528397 0.323557238376305 no 2256 0.334733561759805 3122 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1570 verbenone 133 µM -0.427218754021248 0.323430418450073 no 2257 0.33461000141036 3312 29025 A natural terpanoid with antifungal properties. SGTC_77 0828-0286 12.516 µM -0.428123214676729 0.323092448590808 no 2258 0.33428070805577 3245 745345 SGTC_994 3910-0338 138 µM -0.428259653737352 0.323041478066014 no 2259 0.33423104478771 3320 3479481 SGTC_1322 1348-1070 12 µM -0.429858911288169 0.322444279828936 no 2260 0.333649138035291 3259 6758089 SGTC_1014 4130-3005 69.3 µM -0.434441431578699 0.320735605024362 no 2261 0.331983958413717 3141 743608 SGTC_2504 purpurogallin 52.29 µM -0.43513345481068 0.320477900357036 no 2262 0.331732780648223 3144 5281571 An antioxidant. SGTC_1323 1348-1351 11.2 µM -0.436910902710187 0.31981638782267 no 2263 0.33108798235762 3173 6989654 SGTC_1131 3454-3128 32.3 µM -0.437599823482453 0.319560146150412 no 2264 0.330838199592781 3297 710982 SGTC_2986 9022445 71.43 µM -0.438129058637909 0.319363357469771 no 2265 0.330646365349225 3301 6459286 SGTC_565 1418-0001 44.5 µM -0.438176499123503 0.319345719873249 no 2266 0.330629171554817 3319 2862145 SGTC_2508 celastrol 40.54 µM -0.438443511829964 0.319246456542916 no 2267 0.330532405149556 3201 122724 Celastrol is a natural product and antioxidant. SGTC_784 4579-0127 173 µM -0.438797280272888 0.319114961281399 no 2268 0.330404215587783 3351 1948547 SGTC_578 3460-0051 92 µM -0.440708323606887 0.318405022847008 no 2269 0.32971208496385 3315 2876744 SGTC_752 1896-0090 130 µM -0.442141580792613 0.317873015511181 no 2270 0.329193378424207 3205 772567 SGTC_2177 5811945 192 µM -0.442519801519408 0.317732687265592 no 2271 0.329056552266209 3307 5343475 SGTC_1295 1013-0063 9.78 µM -0.443045628573872 0.317537637309433 no 2272 0.328866365692727 3311 6826038 SGTC_3002 9075603 71.4286 µM -0.443609872109782 0.317328393495015 no 2273 0.328662333524545 3247 20105405 SGTC_200 k038-0079 37.545 µM -0.443820804296248 0.317250186484686 no 2274 0.32858607291821 3171 3436683 SGTC_766 1391-0721 126 µM -0.444169372817028 0.317120966141835 no 2275 0.328460066799045 3308 1020919 YIL115C NUP159 SGTC_1696 st025591 34.7925 µM -0.444987869022785 0.316817623195713 no 2276 0.328164260415544 3173 2787147 SGTC_3054 9094397 49.47 µM -0.445608692449066 0.316587621865005 no 2277 0.327939965252125 3209 2598354 SGTC_1398 3558-0053 112 µM -0.446018051168716 0.316436002307537 no 2278 0.32779210338366 3107 4532369 SGTC_489 paxilline 115 µM -0.447487432115072 0.315892022646811 no 2279 0.327261580095897 3252 105008 A toxic potassium channel blocker. SGTC_1776 st049249 45.9 µM -0.44776671149575 0.315788675629812 no 2280 0.327160785059562 3242 1822314 SGTC_1231 0242-0792 125 µM -0.44777746594997 0.315784696244148 no 2281 0.327156903909335 3162 3707635 SGTC_473 2-arachidonoylglycerol 10 µM -0.448606448338858 0.315478018734053 no 2282 0.326857790636729 3147 5282280 An endocannabinoid. SGTC_2356 9061756 188.97 µM -0.450092069694185 0.314928739197362 no 2283 0.326322027368406 3238 20104043 SGTC_3341 9147222 25.867 µM -0.45053991540964 0.314763237167322 no 2284 0.326160589879601 3316 1939759 SGTC_2900 5328528 85.29 µM -0.450625676593038 0.31473154824128 no 2285 0.326129678773665 3232 795359 SGTC_3102 9121669 49.47 µM -0.451770946817705 0.314308499478253 no 2286 0.325717000885338 3209 41905072 SGTC_2505 galangin 7.89 µM -0.451950177673635 0.314242315847722 no 2287 0.32565243751969 3113 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1086 cerivastatin 2.18 µM -0.452938781614675 0.313877366659818 no 2288 0.325296412069291 3273 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_609 0986-0026 86.3 µM -0.453334122624638 0.313731475032048 no 2289 0.325154082703621 3198 2848610 SGTC_136 0097-0015 404.482 µM -0.454212179846836 0.313407552135498 no 2290 0.324838058700561 3303 4861337 SGTC_2070 5230947 200 µM -0.455381607021203 0.312976363769882 no 2291 0.324417362639469 3320 2835538 SGTC_1495 4469-0029 237 µM -0.455666418815351 0.312871387349766 no 2292 0.324314936802835 3251 793680 SGTC_1724 st037281 8.293 µM -0.455905617687242 0.312783234740409 no 2293 0.324228924845654 3181 574124 YDL195W SEC31 SGTC_2757 clomiphene 4.22 µM -0.456551952535528 0.3125450927628 no 2294 0.32399656044978 3401 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_1588 farnesol 29.9 µM -0.456563204048312 0.312540947837293 no 2295 0.323992516015659 3206 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3293 9120939 62.045 µM -0.459115575289431 0.311601297822849 no 2296 0.323075586226585 3312 934087 SGTC_2582 agaric acid 100 µM -0.459415725590698 0.311490878550653 no 2297 0.322967828832588 3300 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1944 st076371 56.9 µM -0.459652834897738 0.311403662780277 no 2298 0.322882714381555 3188 24208455 SGTC_1957 st077035 62.4 µM -0.461679782304447 0.310658524315511 no 2299 0.322155485827575 3326 705593 SGTC_2737 bleomycin 30.5 nM -0.462345427147799 0.310413991687085 no 2300 0.321916813907658 3301 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.463379389529342 0.310034319335644 no 2301 0.321546224659966 3355 688664 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.463951973821897 0.309824152703414 no 2302 0.321341077313463 3333 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1505 k297-0037 20.6 µM -0.463970365712176 0.309817403003729 no 2303 0.321334488710681 3211 4089396 SGTC_289 k017-0060 526 µM -0.464887467313559 0.309480914248356 no 2304 0.321006022953103 3219 5512909 SGTC_1644 st010134 20.9 µM -0.465416100512217 0.309287028839862 no 2305 0.3208167532172 3324 3818134 SGTC_2299 7976368 114.88 µM -0.467310955936043 0.308592494207131 no 2306 0.320138709544002 3312 2979718 SGTC_1711 st032263 62.8 µM -0.467902700919663 0.308375737860907 no 2307 0.319927085959111 3264 3958979 SGTC_681 1642-0006 26.6 µM -0.468089797093306 0.308307218374766 no 2308 0.319860187629169 3317 4446530 SGTC_330 1488-0319 80.1 µM -0.468443210444301 0.308177807433944 no 2309 0.319733836718498 3291 6846614 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.468760202032908 0.308061753493506 no 2310 0.319620524962434 3333 7104 SGTC_2903 5923464 63.88 µM -0.469210682194762 0.307896861002818 no 2311 0.319459525370891 3319 2876576 SGTC_1337 1486-1011 40.3 µM -0.47036211522051 0.307475570007489 no 2312 0.319048163065221 3330 X1337 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.470842972422837 0.307299707126351 no 2313 0.318876437366052 3282 6708739 YPR165W RHO1 SGTC_2011 4012611 177 µM -0.471598832560087 0.307023357566191 no 2314 0.318606580084007 3204 2049887 SGTC_1252 0493-0875 34.8 µM -0.471922227368168 0.306905154855105 no 2315 0.318491150999155 3200 3960963 SGTC_2600 tangeritin 87.95 µM -0.474803412874117 0.3058529516383 no 2316 0.317463550099096 3249 68077 A bioactive flavone. SGTC_1294 1000-1494 117 µM -0.475000781162814 0.305780931611197 no 2317 0.317393208248651 3270 712797 YDL207W GLE1 SGTC_1154 4088-0362 150 µM -0.475604770255886 0.305560581626001 no 2318 0.317177988147518 3275 6618304 SGTC_502 l-744,832 89.3 µM -0.475685074701604 0.305531289902336 no 2319 0.317149377830041 3330 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_904 1141-0088 396 µM -0.47633589251684 0.305293944550129 no 2320 0.316917549251669 3263 1378119 SGTC_3134 9127454 49.47 µM -0.476738780057123 0.305147057362112 no 2321 0.316774072213195 3371 24262820 SGTC_2160 5660466 132.927 µM -0.479024820447766 0.304314193593384 no 2322 0.315960485670492 3329 2859134 SGTC_51 1013-0126 23.419 µM -0.479333624152841 0.30420176604274 no 2323 0.31585065268299 3484 1627850 SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.479370279953592 0.304188421829503 no 2324 0.315837616301697 3380 1273210 SGTC_2285 7945142 200 µM -0.48179745723752 0.303305410883843 no 2325 0.314974917945871 3332 2970608 SGTC_2465 5809242 33.21 µM -0.481961246659364 0.303245865317866 no 2326 0.314916738088552 3294 2731748 SGTC_550 4123-0385 25.7 µM -0.482791193958469 0.302944218746724 no 2327 0.314622002029864 3253 5731123 SGTC_807 1315-0151 48 µM -0.483010944838801 0.302864372192737 no 2328 0.314543982491555 3421 4011080 SGTC_510 ag-490 170 µM -0.484935873010999 0.302165352057233 no 2329 0.313860917404287 3390 5328779 SGTC_1761 st044296 37 µM -0.486442520309527 0.301618732596698 no 2330 0.313326724762794 3229 1826700 SGTC_843 0310-0051 143 µM -0.488501231879865 0.300872541338246 no 2331 0.312597426686687 3301 2065037 SGTC_3186 9110464 49.47 µM -0.489806441437749 0.300399892697437 no 2332 0.312135436078416 3382 17018021 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.490785051770678 0.300045733916753 no 2333 0.31178924183503 3267 6708784 An antioxidant flavonoid SGTC_2960 9079389 5.97 µM -0.491000903543824 0.299967642659828 no 2334 0.311712904247569 3369 16457355 SGTC_2267 7931562 200 µM -0.491053299412979 0.299948688171919 no 2335 0.311694375278281 3189 934880 SGTC_257 daunorubicin 18.5 µM -0.491437405398677 0.299809752317071 no 2336 0.311558556839762 3369 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_929 2805-0021 398 µM -0.491553216933789 0.299767867579763 no 2337 0.31151761134368 3340 3098024 SGTC_3005 9076496 71.4286 µM -0.492189321044474 0.299537859577013 no 2338 0.311292756506169 3346 21368410 SGTC_3001 9076041 71.4286 µM -0.492558616704251 0.299404363181163 no 2339 0.311162247404477 3290 16004211 SGTC_1053 3366-3204 134 µM -0.493687146168999 0.298996579251624 no 2340 0.310763572206943 3278 3632071 YPR165W RHO1 SGTC_2655 perillic acid 100 µM -0.495594755556879 0.298307855970726 no 2341 0.310090176841183 3271 5702197 An apoptosis inducer. SGTC_2138 5575593 77.673 µM -0.496432752453112 0.298005534076575 no 2342 0.309794560928525 3294 762213 SGTC_1161 k007-0610 110 µM -0.496500534509015 0.297981086631405 no 2343 0.309770655169332 3415 5843850 SGTC_830 4076-0286 57.8 µM -0.498171754652385 0.297378604916478 no 2344 0.309181494445468 3341 6866659 SGTC_1830 st055982 50.3 µM -0.498204016927359 0.297366979710522 no 2345 0.309170125739704 3362 455313 An antimicrobial agent. SGTC_1896 st058441 89 µM -0.498279191115816 0.297339892673487 no 2346 0.309143636276154 3285 688759 SGTC_8 0354-0001 70 µM -0.498842120920678 0.297137091593839 no 2347 0.308945305736134 3341 4993152 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.498863802953933 0.297129281689927 no 2348 0.308937667869827 3263 4174840 SGTC_2862 9027634 71.43 µM -0.499226016331454 0.296998825720261 no 2349 0.308810084244999 3219 5012562 SGTC_976 1348-1067 47.6 µM -0.503623029586748 0.29541727673504 no 2350 0.307263153052669 3314 5310671 YGL099W LSG1 SGTC_1866 st057638 64 µM -0.503693674917262 0.29539189817147 no 2351 0.307238326900699 3301 688802 SGTC_1878 temozolomide 1 mM -0.504766615827037 0.29500657922633 no 2352 0.306861383109157 3391 5394 DNA alkylating agent. SGTC_130 0136-0219 337.655 µM -0.505324106197134 0.294806462450979 no 2353 0.306665607083687 3301 234244 SGTC_1703 st026983 48.3 µM -0.505455928601012 0.294759152623374 no 2354 0.306619322565585 3403 1104023 SGTC_2319 6033012 152.6 µM -0.507110389994591 0.294165679819478 no 2355 0.306038682616265 3246 847246 SGTC_1279 0874-0590 65.2 µM -0.507916653141373 0.293876664931829 no 2356 0.305755897689262 3330 3523074 SGTC_2961 9083290 32.55 µM -0.509099828832699 0.293452779084544 no 2357 0.305341125895555 3370 17741490 SGTC_855 0428-0020 25 µM -0.509448321130607 0.293327981860378 no 2358 0.305219006703654 3321 6812414 SGTC_547 1120-0019 610 nM -0.509945634535034 0.293149933492895 no 2359 0.305044774942374 3334 3676939 SGTC_2884 9058502 51.95 µM -0.511163695826725 0.29271405447823 no 2360 0.304618218730371 3397 6471554 SGTC_806 3966-4455 5.86 µM -0.511611260089818 0.29255397080874 no 2361 0.304461551654746 3284 714982 SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.513200006073712 0.291986040895698 no 2362 0.303905710857427 3425 688801 SGTC_403 arphamenine a 50 µM -0.513868242100943 0.291747319651446 no 2363 0.303672056188831 3348 5487158 An arginine aminopeptidase inhibitor. SGTC_2120 5538279 151.968 µM -0.513943964190908 0.291720274361373 no 2364 0.303645584345498 3371 2058197 SGTC_637 1181-0519 7.26 µM -0.515075602863837 0.291316231770052 no 2365 0.303250095223194 3385 6252091 YGR060W ERG25 SGTC_1414 3917-0015 5.4 µM -0.517005137193491 0.290627909841122 no 2366 0.30257628635386 3383 6618702 SGTC_744 1594-0068 283 µM -0.517121527578668 0.290586414292845 no 2367 0.302535663364292 3330 668392 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.519217641545682 0.289839581818265 no 2368 0.301804489050097 3426 368090 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.519426406850669 0.289765249357734 no 2369 0.301731710267752 3343 4620898 SGTC_125 0133-0007 11.75 µM -0.521528751528434 0.28901719275228 no 2370 0.300999240995111 3456 26541 SGTC_1844 rapamycin 4 nM -0.522650003521783 0.288618600505291 no 2371 0.300608918245186 3356 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2890 9046729 58.44 µM -0.52289415890577 0.288531840405648 no 2372 0.300523954810585 3280 903329 SGTC_1391 3442-0225 151 µM -0.526960882459607 0.287088549058031 no 2373 0.299110376684187 3328 5227075 SGTC_3135 9127742 49.47 µM -0.527028011717679 0.287064753408559 no 2374 0.299087068142747 3333 3643468 SGTC_665 3914-0008 307 µM -0.527566611946493 0.286873866864499 no 2375 0.298900085865975 3319 1069549 SGTC_1035 k081-0041 55.2 µM -0.530217677070621 0.285935174518604 no 2376 0.297980508134206 3455 731709 SGTC_656 4090-1979 187 µM -0.53105510032327 0.2856389624279 no 2377 0.297690298488459 3449 22330961 SGTC_159 3970-0959 50 µM -0.531479728219614 0.285488819500182 no 2378 0.297543192670764 3494 6615653 SGTC_2444 5485484 36.41 µM -0.532610508729585 0.285089173504758 no 2379 0.297151613071044 3435 6790631 SGTC_652 0437-0092 114 µM -0.532798163953086 0.285022877286101 no 2380 0.297086652474935 3395 3091274 SGTC_2211 7117706 200 µM -0.533262902615363 0.284858722644408 no 2381 0.296925801885749 3397 822771 SGTC_2197 6588183 93.1375 µM -0.533468915721517 0.284785969281287 no 2382 0.296854511487041 3368 884136 SGTC_2688 kanamycin b 96.69 µM -0.534632883167585 0.284375081776967 no 2383 0.296451870261812 3529 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_3258 9138477 49.47 µM -0.535396906543747 0.284105531026102 no 2384 0.296187714386329 3418 4970355 SGTC_2877 9040724 71.43 µM -0.536176997785011 0.283830437610538 no 2385 0.295918114621029 3456 6463895 SGTC_1121 fusaric acid 630.51 nM -0.536934184227601 0.283563543419479 no 2386 0.295656538584168 3305 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1785 bathophenanthroline 24 µM -0.537055239491434 0.283520884834072 no 2387 0.295614728942564 3313 72812 An iron chelator. SGTC_72 0744-0168 198.391 µM -0.537220278419842 0.283462731828741 no 2388 0.295557732756425 3238 677577 SGTC_249 wiskostatin 11.211 µM -0.537826607074377 0.283249135372201 no 2389 0.295348380576879 3440 2775510 A n-wasp and actin depolymerizer. SGTC_193 1273-0060 1.558 µM -0.540115386858799 0.2824435442907 no 2390 0.294558729989274 3378 2847393 YHR072W ERG7 SGTC_3121 9125696 49.47 µM -0.540839899416279 0.282188764480868 no 2391 0.294308969477913 3439 1235365 SGTC_3126 9127922 49.47 µM -0.541783360953164 0.281857155673974 no 2392 0.293983877582445 3479 45595682 SGTC_913 3487-1245 167 µM -0.542146275365992 0.281729648178063 no 2393 0.293858871104441 3328 4016153 SGTC_1645 Cervolide 78 µM -0.542629538828321 0.281559900046589 no 2394 0.293692448374936 3401 23173 A fragrance. SGTC_313 3474-0040 5.03 µM -0.544623904449583 0.280859893882608 no 2395 0.293006105281962 3380 1043375 YIL048W NEO1 SGTC_3035 9091303 49.47 µM -0.545586033309534 0.280522495566019 no 2396 0.292675263547343 3451 25237002 SGTC_2540 epiandrosterone 100 µM -0.545893915318943 0.280414569278251 no 2397 0.292569430584657 3500 441302 A steroid. SGTC_2718 lomofungin 53.02 µM -0.545900932658728 0.280412109624029 no 2398 0.292567018615078 3464 5351222 A RNA synthesis inhibitor. SGTC_2756 carbadox 75.1 µM -0.546813340131339 0.280092389846846 no 2399 0.292253488610883 3371 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_554 4483-2211 187 µM -0.548646972261865 0.279450395442943 no 2400 0.291623871888998 3407 747107 SGTC_2331 7980721 200 µM -0.549085559171138 0.279296942628623 no 2401 0.29147336748273 3367 2981221 SGTC_724 3910-0327 137 µM -0.550142822512971 0.278927195673284 no 2402 0.291110708609033 3439 2885483 SGTC_2813 7971799 71.43 µM -0.550293182492978 0.278874631012267 no 2403 0.291059149761455 3437 2234054 SGTC_2818 7996756 12.99 µM -0.550530132299113 0.278791805016371 no 2404 0.290977907684739 3366 2241621 SGTC_1901 st060216 58.6 µM -0.550774573783735 0.278706372846656 no 2405 0.290894108069867 3424 688792 SGTC_2083 5306046 65.942 µM -0.550777568173894 0.278705326387904 no 2406 0.290893081600702 3410 539837 SGTC_422 cantharidin 155 µM -0.552165743387868 0.278220402629225 no 2407 0.290417401160195 3409 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1707 st032323 6.317 µM -0.552408871269038 0.278135514434322 no 2408 0.290334126992028 3410 3132057 YMR211W DML1 SGTC_940 3232-1287 54.8 µM -0.55244092342568 0.278124324353823 no 2409 0.29032314958445 3452 1585493 YIL048W NEO1 SGTC_2369 9071472 200 µM -0.552464834717639 0.278115976563037 no 2410 0.29031496043378 3447 17296037 SGTC_2902 5787006 60.46 µM -0.553005907699856 0.277927112545726 no 2411 0.290129682427229 3348 591003 SGTC_3302 9125395 16.351 µM -0.554091209000129 0.277548471935724 no 2412 0.289758213078837 3347 17599668 SGTC_746 1095-0025 46.6 µM -0.554776660853933 0.27730946100454 no 2413 0.28952371644796 3482 6749286 SGTC_3356 9151811 4.48 µM -0.554885420817816 0.277271546632364 no 2414 0.289486517294216 3355 1859254 YPR165W RHO1 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.555602068290808 0.277021782460848 no 2415 0.289241458613674 3334 6708514 SGTC_2938 9059746 27.26 µM -0.556728782158552 0.276629325799456 no 2416 0.288856374405257 3418 6471769 SGTC_1248 0469-0687 58.6 µM -0.55755471379742 0.276341810714087 no 2417 0.288574243831308 3429 4017482 SGTC_1569 carminic acid 40.6 µM -0.558144651115063 0.276136537404978 no 2418 0.288372806240038 3473 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2346 9031566 143.75 µM -0.558803511537531 0.275907370275215 no 2419 0.28814791283948 3375 4771086 SGTC_2944 9067346 25.62 µM -0.558953455895266 0.275855229159289 no 2420 0.288096742852764 3447 6473075 SGTC_1619 st003326 88.7 µM -0.559136560078403 0.275791563730294 no 2421 0.288034262565515 3466 2849032 SGTC_2140 5586273 200 µM -0.559693503910796 0.275597958436573 no 2422 0.28784425701894 3451 854421 SGTC_2264 7948757 110.76 µM -0.561158100007145 0.27508915345077 no 2423 0.287344881853893 3359 2971411 SGTC_2014 4013930 200 µM -0.561902053283225 0.274830879202644 no 2424 0.287091377329796 3477 64556 SGTC_1705 st027868 56.3335 µM -0.562167752146204 0.274738666936302 no 2425 0.287000865240762 3437 292948 SGTC_3045 9092950 49.47 µM -0.563104567102828 0.274413661868176 no 2426 0.286681840870538 3511 44120432 SGTC_998 3996-0085 177 µM -0.563442552218134 0.274296452785992 no 2427 0.286566784202908 3408 715391 SGTC_356 1634-0012 32.5 µM -0.563640262050947 0.274227900907785 no 2428 0.286499490109218 3479 735457 SGTC_841 0251-0215 91.2 µM -0.564155852592218 0.274049170147495 no 2429 0.286324034885381 3436 3888614 SGTC_972 1319-0219 195 µM -0.564172857412316 0.274043276364434 no 2430 0.28631824902199 3417 23903702 SGTC_1557 sumaresinolic acid 42.3 µM -0.564533463034699 0.273918307062496 no 2431 0.286195566595169 3408 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2244 6635614 200 µM -0.564691628471109 0.273863503095534 no 2432 0.286141764664434 3256 836499 SGTC_672 1441-0018 53.7 µM -0.565600539265704 0.273548672686047 no 2433 0.285832680582742 3386 251141 SGTC_2044 5102272 200 µM -0.565759842126696 0.273493511484073 no 2434 0.285778524429324 3462 592666 SGTC_2072 5231554 129 µM -0.565866329826793 0.273456641459722 no 2435 0.285742325891415 3522 789545 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.567843202443324 0.27277262142019 no 2436 0.285070720749276 3471 756377 SGTC_78 0336-0123 156.75 µM -0.570681322998854 0.271792086439253 no 2437 0.28410784072956 3280 6765896 SGTC_1343 1487-0095 224 µM -0.572785582961833 0.271066225182994 no 2438 0.283394940917317 3493 4560101 YGL055W OLE1 SGTC_1801 st050089 28.441 µM -0.573198119321265 0.270924034837076 no 2439 0.28325527881125 3481 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_543 3844-1095 191 µM -0.574163452455733 0.270591455605442 no 2440 0.282928599210113 3453 4230703 SGTC_1730 st033808 45.1 µM -0.576034939514345 0.26994726718579 no 2441 0.282295782742924 3363 1045166 SGTC_1159 4092-0538 61.2 µM -0.576492877933883 0.269789756225198 no 2442 0.282141041219423 3498 717301 SGTC_1937 st074714 47.2 µM -0.578443605449593 0.269119306526252 no 2443 0.281482330648953 3354 17250970 SGTC_2889 9059656 51.95 µM -0.578628997418737 0.269055632293863 no 2444 0.28141976717181 3484 3949838 SGTC_2466 5983409 37.09 µM -0.579138548767143 0.26888066210194 no 2445 0.281247845516998 3418 2879657 SGTC_1933 st074711 15.9 µM -0.579374810015044 0.268799553898175 no 2446 0.281168148632845 3478 17250958 SGTC_1430 4049-0248 69.1 µM -0.579599843584099 0.268722311571297 no 2447 0.281092249271396 3520 22774488 SGTC_2895 9054447 58.44 µM -0.581591136611514 0.268039290468289 no 2448 0.280421057252056 3463 2697450 SGTC_278 4092-0821 23.9 µM -0.581999695983813 0.267899261178114 no 2449 0.280283442826768 3478 877900 SGTC_2619 obliquin 87.91 µM -0.58272046234411 0.267652316198618 no 2450 0.280040747985519 3487 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2802 7925815 54.55 µM -0.58597435138653 0.26653891677679 no 2451 0.278946375485449 3433 1262923 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.586146402690478 0.266480110392463 no 2452 0.278888567854268 3525 364106 SGTC_1075 aripiprazole 15.2 µM -0.587339119831813 0.266072625407608 no 2453 0.278487986375138 3476 60795 An atypical antipschotic. YIL048W NEO1 SGTC_224 benfluorex 43.875 µM -0.589493625246449 0.265337351704089 no 2454 0.27776509360639 3506 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_5 0352-0601 109.883 µM -0.590581696309651 0.264966415178032 no 2455 0.277400365940299 3439 762456 SGTC_121 0557-0495 61.343 µM -0.591443114740868 0.264672934263212 no 2456 0.277111779695281 3531 3104427 SGTC_1583 clindamycin 39.6 µM -0.591483126816467 0.264659306369869 no 2457 0.277098378707039 3435 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_977 1348-1378 135 µM -0.59241285045661 0.264342748124298 no 2458 0.276787081653114 3485 X977 SGTC_2871 9038510 12.99 µM -0.593568095452992 0.263949671671472 no 2459 0.276400512683477 3557 4945164 SGTC_595 3909-8003 73.7 µM -0.596186163940774 0.263059967969211 no 2460 0.275525433840095 3558 699517 SGTC_1958 st076513 41.9 µM -0.597049925092257 0.262766770800398 no 2461 0.275237024385789 3427 732122 YGL099W LSG1 SGTC_3326 9140064 16.379 µM -0.59751847080034 0.262607796470689 no 2462 0.275080639386055 3475 1868434 SGTC_1616 st002734 56.1 µM -0.597569265642072 0.262590565088514 no 2463 0.275063688384205 3454 4026101 SGTC_584 0986-0246 15.4 µM -0.597986657148971 0.262448993245445 no 2464 0.274924418054371 3579 53315 YDR232W HEM1 SGTC_1240 0356-0016 42.1 µM -0.599582812331144 0.261907966218904 no 2465 0.274392152341656 3455 4305613 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.601787655233897 0.261161562379187 no 2466 0.273657746714365 3521 616764 SGTC_1955 wogonin 32.4 µM -0.602291997152662 0.260990981642209 no 2467 0.273489893490145 3608 5281703 A flavanone. SGTC_3122 9126309 49.47 µM -0.603269109153517 0.260660661622859 no 2468 0.273164839748739 3547 17591206 SGTC_2125 5246583 200 µM -0.603663361124947 0.26052744274632 no 2469 0.273033739021169 3585 835267 SGTC_3099 9120367 49.47 µM -0.603895155508227 0.260449135124248 no 2470 0.2729566749269 3549 24824940 SGTC_959 1222-0044 107 µM -0.605135464094613 0.260030324925356 no 2471 0.272544496004044 3519 6083612 SGTC_2965 9082772 38.63 µM -0.605396952592915 0.259942073460391 no 2472 0.272457637693855 3583 16459634 SGTC_1244 0416-0015 52.5 µM -0.606685307140461 0.25950748392226 no 2473 0.272029887384447 3511 96201 SGTC_2240 6690706 185.951 µM -0.608102428389469 0.259029892342593 no 2474 0.271559770872322 3444 805876 SGTC_2164 5685496 200 µM -0.608539073566954 0.258882827883832 no 2475 0.271414999564748 3543 759046 SGTC_3038 9091290 49.47 µM -0.608585651587921 0.258867142704502 no 2476 0.271399558721324 3569 25236843 SGTC_956 1185-0240 191 µM -0.608609788956876 0.258859014622989 no 2477 0.271391557236777 3509 1416193 SGTC_1771 st048882 4.1505 µM -0.609007661753821 0.258725052914419 no 2478 0.271259680222382 3414 4580403 SGTC_2686 alizarin 95.37 µM -0.609271219459717 0.258636334162806 no 2479 0.271172340237267 3467 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2987 9018338 71.43 µM -0.610431370548573 0.258245991643173 no 2480 0.270788046325444 3580 5055682 SGTC_1447 4239-0816 81.9 µM -0.610681637522533 0.258161827288707 no 2481 0.270705182377062 3464 1341554 SGTC_2739 tacrine 100.86 µM -0.611161423400084 0.258000515894115 no 2482 0.270546359624201 3530 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2513 baicalein 25.65 µM -0.611751136538235 0.257802316909361 no 2483 0.270351211617632 3490 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_3270 9137563 49.47 µM -0.6129560751436 0.257397590224662 no 2484 0.269952691948708 3486 17015724 SGTC_3194 9111903 49.47 µM -0.614680676903279 0.256818888900838 no 2485 0.269382811654252 3571 17087251 SGTC_528 3492-0019 172 µM -0.615507974619523 0.256541524308393 no 2486 0.269109652239939 3561 2869262 SGTC_366 0181-0206 4.31 µM -0.616159070257675 0.256323344013323 no 2487 0.268894769489372 3586 274874 SGTC_1481 3346-2004 36 µM -0.616561119138612 0.256188666892766 no 2488 0.268762123313024 3547 2770522 SGTC_2815 7968870 71.43 µM -0.616575896748224 0.256183717436801 no 2489 0.268757248429189 3551 2977326 YHR190W ERG9 SGTC_1052 3253-3998 198 µM -0.618905105722307 0.255404220570847 no 2490 0.267989437392888 3521 5450317 SGTC_2000 st075254 36.4 µM -0.619431637574694 0.255228182487198 no 2491 0.267816022221943 3526 17234175 SGTC_1192 1488-0095 21.4 µM -0.619822332762009 0.255097600383206 no 2492 0.267687381895075 3528 915875 SGTC_532 1548-0774 215 µM -0.620077440622071 0.255012354511534 no 2493 0.267603401870282 3651 5932993 SGTC_2783 7738165 71.43 µM -0.622225550339827 0.25429514187158 no 2494 0.266896783811495 3484 17201110 SGTC_2659 sanguinarine 24.21 µM -0.622466351286107 0.254214809020227 no 2495 0.266817631430556 3498 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_345 1362-0200 395 µM -0.622711272666227 0.254133115216556 no 2496 0.26673713681357 3487 1419823 SGTC_654 1124-0271 80.9 µM -0.625304487542097 0.253268990874273 no 2497 0.265885617630627 3535 5403748 SGTC_50 0929-0078 56.389 µM -0.62574410166435 0.253122653702658 no 2498 0.265741400720351 3454 1377751 SGTC_2947 9072639 7.68 µM -0.625779396954096 0.253110906662256 no 2499 0.265729823700298 3574 16488146 SGTC_1335 1486-0900 202 µM -0.625938463573954 0.253057969388679 no 2500 0.265677652278327 3575 X1335 SGTC_1012 4112-3522 18 µM -0.626038265265083 0.253024758421043 no 2501 0.265644921499665 3564 3112398 SGTC_1482 3346-2049 8.48 µM -0.627243844070195 0.252623759693148 no 2502 0.26524970370529 3544 3826804 SGTC_2674 ligustilide 100 µM -0.62737971612149 0.252578587031024 no 2503 0.265205180297207 3540 5319022 A signalling regulator. SGTC_1945 st075991 56.6 µM -0.628206648855872 0.252303752864081 no 2504 0.264934287634362 3495 1084980 SGTC_2133 5320837 200 µM -0.628889047581253 0.252077073905168 no 2505 0.264710848424668 3551 2841355 SGTC_643 k048-0106 28.4 µM -0.629836847037769 0.251762412561798 no 2506 0.264400667572772 3565 6763920 SGTC_2824 7998404 51.95 µM -0.629912153154422 0.251737420469659 no 2507 0.264376030510991 3534 837851 SGTC_544 k015-0020 52.4 µM -0.63036964940594 0.251585617822137 no 2508 0.264226381687118 3558 3008304 SGTC_2747 doxorubicin 7.63 µM -0.631165544996014 0.251321645573331 no 2509 0.263966143952005 3470 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2651 TUB2.036 5 µM -0.632238913423522 0.250965876790302 no 2510 0.263615386617205 3670 15992207 YFL037W TUB2 SGTC_1269 0831-0796 3.05 µM -0.633112878391897 0.250676397405107 no 2511 0.26332996645557 3577 927758 SGTC_1854 st056233 32.9 µM -0.633414800009171 0.250576434415524 no 2512 0.263231401344318 3542 5393174 SGTC_2108 5365811 200 µM -0.635524014450643 0.249878685776745 no 2513 0.26254335479384 3578 780283 SGTC_2265 7929201 200 µM -0.635799704730851 0.249787561024184 no 2514 0.262453489975072 3568 1265108 SGTC_2507 purpurin 79.67 µM -0.64020397834978 0.248334198561784 no 2515 0.261019998356904 3518 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.641045668895912 0.248056963790851 no 2516 0.260746505968443 3620 165521 SGTC_1888 azatryptophan 97.5 µM -0.641145545257758 0.248024077626978 no 2517 0.260714062708445 3546 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_450 aminopyrene 156 nM -0.641257756855737 0.247987132630525 no 2518 0.260677615019815 3554 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2567 aureobasidin a 60 nM -0.641786950915917 0.247812938243764 no 2519 0.260505761720368 3632 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_416 estradiol valerate 100 µM -0.642053790490567 0.247725127653698 no 2520 0.260419128944542 3578 13791 A steroid. SGTC_581 0958-0271 211 µM -0.642938750347716 0.247434027269153 no 2521 0.260131922003829 3582 4591145 SGTC_2332 7982454 138.89 µM -0.644424404872112 0.246945744579858 no 2522 0.259650131616907 3573 2981748 SGTC_1486 3970-0793 4.53 µM -0.645783848698756 0.246499395127326 no 2523 0.259209674672201 3611 2844330 SGTC_2418 pentamidine 31.67 µM -0.645992774568232 0.246430836336495 no 2524 0.25914201738231 3580 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2774 tamoxifen 10.92 µM -0.647162119840993 0.246047305711345 no 2525 0.258763512295852 3623 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2791 5663188 71.43 µM -0.647765341860981 0.245849581704325 no 2526 0.2585683674391 3573 54690634 SGTC_2470 5664817 21.68 µM -0.648608121223897 0.245573478509098 no 2527 0.258295852448094 3620 2859561 SGTC_1871 st057448 67.3 µM -0.649935973484859 0.245138798604924 no 2528 0.25786679003083 3680 691747 SGTC_301 4119-0100 24.5 µM -0.651006912548993 0.244788522344157 no 2529 0.257521012337847 3599 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_198 3454-2873 16.191 µM -0.651131926646431 0.244747651058785 no 2530 0.257480664319485 3577 710957 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.651707574789773 0.2445594998631 no 2531 0.257294917562423 3615 23665772 A membrane-active detergent. SGTC_2453 5731132 22.18 µM -0.652086072195657 0.244435830058939 no 2532 0.257172824208489 3645 1362040 SGTC_2032 5185112 25.99 µM -0.652314125221819 0.244361332548281 no 2533 0.257099274818442 3537 5718189 SGTC_1047 2043-3044 82 µM -0.652450295983064 0.244316855822006 no 2534 0.257055363597598 3586 669592 SGTC_659 k018-0002 107 µM -0.652973389015887 0.244146041329154 no 2535 0.256886717163606 3601 6797879 YHR007C ERG11 SGTC_115 0527-0192 112.043 µM -0.653194577231611 0.244073832344675 no 2536 0.256815422882519 3620 4233931 SGTC_3188 9110789 49.47 µM -0.653727044953959 0.243900050472608 no 2537 0.256643837976204 3630 849217 SGTC_1004 4084-0029 199 µM -0.653799281011341 0.243876479883161 no 2538 0.25662056488845 3614 716894 YLR208W SEC13 SGTC_866 0495-0101 262 µM -0.654382531036206 0.243686210730128 no 2539 0.256432693062107 3556 635694 SGTC_441 propafenone 146 µM -0.654761634089009 0.243562581858699 no 2540 0.256310617863973 3584 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2250 alverine citrate 130 µM -0.655990157055171 0.243162182473842 no 2541 0.255915228688218 3545 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.656628183070443 0.242954377955369 no 2542 0.255710011340022 3528 641818 YHR062C RPP1 SGTC_1664 st014217 9.02 µM -0.659152916976128 0.242133017403687 no 2543 0.254898788911913 3664 3982782 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.659506681427407 0.242018049149967 no 2544 0.254785228509912 3570 390807 SGTC_725 1497-0963 19 µM -0.659910409976589 0.241886879479498 no 2545 0.254655661716879 3632 3549977 SGTC_1476 4112-3294 3.34 µM -0.660506707407305 0.241693215580756 no 2546 0.254464357795396 3649 704369 SGTC_1266 0828-0227 32.9 µM -0.661645314009784 0.241323655858533 no 2547 0.254099279731031 3579 3913820 SGTC_965 1291-5240 308 µM -0.661932285074361 0.24123056157904 no 2548 0.254007309895589 3610 2834598 SGTC_1526 st051518 75 µM -0.662892232645124 0.240919293585163 no 2549 0.253699788361582 3573 673993 SGTC_48 0382-0018 55 µM -0.66294156476288 0.240903303293582 no 2550 0.253683989981566 3718 762596 SGTC_1274 0865-0114 173 µM -0.663443890052619 0.240740514698367 no 2551 0.253523152075786 3614 870624 SGTC_123 0083-0120 66.675 µM -0.663446261933948 0.24073974618463 no 2552 0.2535223927579 3562 16001701 SGTC_2851 9015922 71.43 µM -0.665091222235176 0.240207083946292 no 2553 0.252996074305236 3613 2996893 SGTC_1721 st082152 9.2685 µM -0.665657063871908 0.240024004717085 no 2554 0.252815161653166 3594 5296051 SGTC_3120 9124077 49.47 µM -0.665858782822417 0.2399587565351 no 2555 0.252750683912771 3669 18774327 YGL155W CDC43 SGTC_1545 lovastatin 49.4 µM -0.666291978590275 0.239818667363047 no 2556 0.252612245853288 3655 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.668825896157555 0.239000129975995 no 2557 0.251803272741028 3643 676296 Flavone; oxidizing agent. SGTC_2191 5911152 200 µM -0.668866244245191 0.238987108603978 no 2558 0.251790402368931 3618 2875902 SGTC_640 3381-0960 37.1 µM -0.669252440810395 0.238862492604932 no 2559 0.25166722963174 3665 1745025 SGTC_1694 st024011 44.9 µM -0.669572282973333 0.238759314426588 no 2560 0.251565243928147 3676 2787533 SGTC_2888 9058547 12.99 µM -0.67032318813645 0.238517175083968 no 2561 0.251325894187409 3558 16476514 SGTC_1797 st048695 56.8 µM -0.670761498826848 0.238375898139836 no 2562 0.25118623906907 3608 592262 YIL048W NEO1 SGTC_1137 ixabepilone 100 µM -0.670992685216183 0.23830140026784 no 2563 0.251112594699267 3640 154225 A novel microtubule stabilizer. SGTC_1819 st053448 58.6 µM -0.673582255175367 0.237467805156542 no 2564 0.250288468894157 3585 2857616 SGTC_2713 st079149 53.4 µM -0.674490759476595 0.237175732968584 no 2565 0.249999679274407 3652 3103253 SGTC_889 0919-1524 82.7 µM -0.675774437808718 0.236763383901059 no 2566 0.249591933307945 3617 3905452 SGTC_826 1683-5028 118 µM -0.675781537659237 0.236761104351243 no 2567 0.249589679103189 3654 722377 SGTC_644 1498-1197 63.3 µM -0.677016560416176 0.236364759172889 no 2568 0.249197723619583 3666 6741615 SGTC_219 mitoxanthrone 164.414 µM -0.67772045751092 0.236139027086634 no 2569 0.248974476441304 3615 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_614 0462-0418 107 µM -0.677845993471697 0.236098781561061 no 2570 0.248934672789034 3517 5188303 SGTC_118 0083-0097 135.343 µM -0.678067850888623 0.236027665617882 no 2571 0.248864336801542 3714 5207356 SGTC_1820 st053765 18.6 µM -0.678903018023216 0.23576006037207 no 2572 0.248599656662428 3629 3690829 SGTC_2419 paclitaxel 166.5 µM -0.679138027235477 0.235684788614042 no 2573 0.248525204876661 3600 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_222 nsc-310342 10.666 µM -0.68074395264573 0.235170777176833 no 2574 0.248016759909843 3605 432556 SGTC_853 0419-0306 21 µM -0.680948816644469 0.235105250541981 no 2575 0.247951938762091 3602 762713 SGTC_2233 sulbentine 40.3845 µM -0.681054087798324 0.235071583031614 no 2576 0.247918633366398 3633 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_726 3448-4391 34.2 µM -0.681742975448103 0.234851330763195 no 2577 0.247700743949589 3712 1356692 SGTC_3250 9135583 49.47 µM -0.681838118753423 0.234820920359399 no 2578 0.247670658955158 3655 7699353 SGTC_1904 st060225 78 µM -0.682278246340125 0.234680271866879 no 2579 0.247531512858682 3635 66595 SGTC_2860 9025725 38.96 µM -0.682285121437259 0.234678075209776 no 2580 0.247529339631832 3621 40546248 SGTC_1336 1486-0901 104 µM -0.683215422636899 0.234380940254213 no 2581 0.247235364292247 3670 5006114 SGTC_1028 k015-0029 4.8 µM -0.683370851508885 0.234331317120288 no 2582 0.247186266949077 3650 4588309 SGTC_1547 harmine 94.2 µM -0.68363040466887 0.234248463619138 no 2583 0.247104290135333 3683 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2325 6158266 200 µM -0.684361925003614 0.234015037964818 no 2584 0.246873326310237 3662 3623240 SGTC_1686 st019653 115.5 µM -0.684702139209285 0.233906520677972 no 2585 0.246765949434557 3653 97252 SGTC_939 1165-0479 45.3 µM -0.685593735680992 0.233622262671521 no 2586 0.246484666444288 3605 1377347 SGTC_1587 estradiol valerate 56.1 µM -0.686027171605638 0.233484144230519 no 2587 0.246347987124654 3653 13791 A steroid. SGTC_2652 actinonin 100 µM -0.686328039332165 0.233388296532525 no 2588 0.246253135641501 3635 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_143 4032-1194 15.74 µM -0.6865970760558 0.233302607756138 no 2589 0.246168335778011 3660 1806963 SGTC_2741 miltefosine 3.04 µM -0.686871686541496 0.23321516173227 no 2590 0.246081795228215 3582 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1156 4092-0367 4.88 µM -0.687482721312219 0.233020651202148 no 2591 0.245889292741964 3658 1357585 SGTC_218 alverine citrate 93.75 µM -0.687825157203002 0.23291168308368 no 2592 0.245781445914726 3660 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_292 k038-0015 474 µM -0.688349048569686 0.232745027966438 no 2593 0.245616500619056 3649 46368540 SGTC_2701 st077767 14.721 µM -0.689229150808125 0.232465207818722 no 2594 0.24533953750954 3669 5721188 SGTC_1276 0871-0068 94.2 µM -0.691981696020958 0.231591270928633 no 2595 0.244474411933676 3643 3414906 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.692162541135438 0.231533916537318 no 2596 0.244417629869674 3670 2374 Ca(2+)-ATPase inhibitor. SGTC_2975 9084847 53.72 µM -0.692254954577168 0.231504610996882 no 2597 0.244388616480106 3685 27211724 SGTC_79 0052-0007 94.094 µM -0.693692531610234 0.231049002439839 no 2598 0.243937525306798 3699 2801472 SGTC_1870 st057514 26.5 µM -0.694443179132027 0.230811300179716 no 2599 0.243702161470332 3666 5393161 SGTC_2779 methotrexate 400 µM -0.694510309376821 0.230790049173439 no 2600 0.243681118907731 3722 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2017 5132927 60.65 µM -0.694727032148147 0.230721450045914 no 2601 0.243613191955073 3666 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_44 0929-0055 61.211 µM -0.694978577265022 0.230641842906953 no 2602 0.24353436353285 3616 1379590 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.696697934491084 0.230098124583689 no 2603 0.242995925854331 3690 115019 SGTC_1256 0570-0116 285 µM -0.697661992756139 0.22979357114907 no 2604 0.242694301244687 3672 410638 SGTC_2931 9014674 55.67 µM -0.69841085586713 0.229557155365816 no 2605 0.242460144618429 3680 2996810 SGTC_740 k014-0057 261 µM -0.698722346122526 0.229458858162379 no 2606 0.242362783019478 3691 4012779 SGTC_858 0438-0351 2.77 µM -0.698790397392114 0.229437386314445 no 2607 0.242341515252933 3690 2799119 SGTC_2367 9070478 135.38 µM -0.698867365267697 0.229413102415308 no 2608 0.242317462037185 3652 572802 SGTC_2112 5488546 200 µM -0.7013915443642 0.22861750513663 no 2609 0.241529348719843 3665 600757 SGTC_1729 st035615 45.989 µM -0.701691880853566 0.2285229451902 no 2610 0.241435668735239 3699 17385451 SGTC_2355 9061122 103.12 µM -0.702302861137899 0.228330647902944 no 2611 0.241245154675691 3677 5302957 SGTC_1762 st045503 25.4615 µM -0.702459826282904 0.228281260060357 no 2612 0.241196223464201 3721 4645554 SGTC_624 k048-0052 28 µM -0.703022560948151 0.228104249404448 no 2613 0.241020844858658 3654 6835531 SGTC_2069 5228469 200 µM -0.705903765458274 0.227199164137853 no 2614 0.240123992874118 3655 2835210 SGTC_2664 lyso-paf C-16 73.48 µM -0.706201594850072 0.227105721268139 no 2615 0.240031389360666 3680 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_113 0099-0221 2.5 µM -0.706612929797663 0.226976702082141 no 2616 0.239903525808918 3700 89219 SGTC_1124 fisetin 1.16336 µM -0.706861395762438 0.226898788357436 no 2617 0.239826308114709 3700 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_1628 st004252 77.7 µM -0.708059782029477 0.226523211430366 no 2618 0.23945406679689 3672 692968 SGTC_816 0325-0417 81.3 µM -0.708188619348854 0.226482854433239 no 2619 0.239414066293329 3690 68101 SGTC_3117 9124945 49.47 µM -0.708996595098939 0.226229856720395 no 2620 0.239163294895742 3618 17592065 SGTC_1846 st056244 14.8 µM -0.71072696048717 0.225688572918848 no 2621 0.238626724693715 3708 5393182 SGTC_2242 6630449 61.2675 µM -0.711626603734415 0.2254074410035 no 2622 0.238348014214196 3727 691249 YDR170C SEC7 SGTC_2734 clemastine 41.6 µM -0.71165740122011 0.225397820526187 no 2623 0.238338476275903 3678 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2553 4-methylesculetin 85.09 µM -0.711723971090199 0.225377026313718 no 2624 0.238317860394422 3729 5319502 SGTC_229 benomyl 22.8748 µM -0.712778350416837 0.225047818171375 no 2625 0.237991462183191 3701 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_690 glyoxal 20.3 µM -0.713757053205207 0.224742482471179 no 2626 0.237688710164746 3603 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_55 0767-0285 6.563 µM -0.714027141012388 0.224658261855847 no 2627 0.237605198391401 3666 3116166 SGTC_2061 5245884 80.95 µM -0.715354295204584 0.224244679817001 no 2628 0.237195073288051 3684 573863 SGTC_1678 st019265 80.2 µM -0.715359671377446 0.224243005315923 no 2629 0.237193412702275 3712 5367020 SGTC_3138 9097216 49.47 µM -0.715366390920045 0.224240912409323 no 2630 0.237191337187058 3710 25237486 SGTC_2738 aclarubicin 5.55 µM -0.716926631097644 0.223755251575073 no 2631 0.236709684372308 3628 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_276 colchicine 750 µM -0.717091693596996 0.223703907054302 no 2632 0.236658760359183 3724 2833 A microtubule depolymerizer. SGTC_2463 5473429 200 µM -0.717929666315079 0.223443349696628 no 2633 0.236400327427433 3704 5399405 SGTC_19 0279-0214 38.434 µM -0.718035832461198 0.223410350960676 no 2634 0.236367596607633 3755 3566274 YBR002C RER2 SGTC_3251 9135047 49.47 µM -0.718348781027706 0.223313095907823 no 2635 0.236271129680762 3689 17682963 SGTC_391 gliotoxin 8.33 µM -0.718748756827007 0.22318883047771 no 2636 0.236147868029695 3759 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_621 3584-0052 32.1 µM -0.718866238012976 0.223152338624758 no 2637 0.236111670258104 3712 2273927 SGTC_2996 9066192 71.4286 µM -0.719810958102696 0.222859014417389 no 2638 0.235820698526038 3742 6472854 SGTC_679 0422-0091 41.4 µM -0.721294636706185 0.222398793779171 no 2639 0.235364128045425 3706 627384 YHR062C RPP1 SGTC_1648 st011736 69.8 µM -0.721435162552325 0.222355232342311 no 2640 0.235320909519795 3733 2855514 SGTC_1840 st055363 71 µM -0.722121841430044 0.222142439603925 no 2641 0.235109785420171 3692 676033 SGTC_2320 7373003 200 µM -0.722123176001562 0.222142026150989 no 2642 0.235109375198955 3740 5415828 SGTC_263 alizarin 107.927 µM -0.722979317162004 0.221876882429184 no 2643 0.234846295619514 3730 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2345 9052315 157.45 µM -0.724367543421305 0.221447338315045 no 2644 0.234420060145055 3733 6469265 SGTC_2038 4100038 30.985 µM -0.724469543327105 0.221415796327546 no 2645 0.234388759389283 3716 3596803 SGTC_2689 tacrolimus 100 µM -0.725520391104847 0.221090986527204 no 2646 0.234066419960025 3728 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_341 1486-1430 230 µM -0.725691103818988 0.221038246161109 no 2647 0.234014078346455 3687 2054753 YPL210C SRP72 SGTC_3327 9140648 26.9345 µM -0.727206371868955 0.220570431569138 no 2648 0.233549771718435 3701 8029710 SGTC_2142 5622915 118.518 µM -0.727465812469424 0.220490390381947 no 2649 0.233470325495916 3726 5322196 SGTC_3000 9075062 71.4286 µM -0.728698021800369 0.22011046327298 no 2650 0.233093201573851 3702 17057871 SGTC_719 2810-4230 27.3 µM -0.731408503976369 0.219276063076452 no 2651 0.232264836255121 3715 721079 SGTC_383 2324-0395 7.37 µM -0.732683145215961 0.218884304339769 no 2652 0.231875853143427 3755 3146421 SGTC_3333 9141820 12.094 µM -0.735875086232994 0.217905035560807 no 2653 0.230903360178661 3739 1939433 SGTC_410 α-linolenic acid 100 µM -0.736048663353001 0.217851855648205 no 2654 0.230850541572291 3808 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2377 9073351 62.6 µM -0.73650233299752 0.217712897383513 no 2655 0.230712524148549 3717 7337946 YHR072W ERG7 SGTC_1737 st035557 69.7 µM -0.736777785400706 0.217628551722318 no 2656 0.230628747272657 3650 5716916 SGTC_418 lividomycin a 100 µM -0.737670114404937 0.217355443184371 no 2657 0.230357468552803 3729 72394 An antibiotic. SGTC_590 k048-0076 22.4 µM -0.738700881551684 0.217040210386794 no 2658 0.230044325182235 3721 6832814 SGTC_1493 4348-0038 111 µM -0.739902031221351 0.216673204136729 no 2659 0.229679720919755 3764 800424 SGTC_549 1661-1316 519 µM -0.741795453679265 0.216095406305152 no 2660 0.229105637759344 3763 2857282 SGTC_1837 st055472 66.5 µM -0.742612857485499 0.215846242962101 no 2661 0.228858050971711 3798 676091 SGTC_355 1311-2252 105 µM -0.743797739136871 0.21548535973832 no 2662 0.228499424076405 3750 5338538 SGTC_2681 menadione 3.18 µM -0.744546142272444 0.215257596636598 no 2663 0.228273068456535 3765 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2786 7743617 45.45 µM -0.744735734544408 0.215199919808919 no 2664 0.228215746012994 3710 583674 SGTC_2992 9074591 71.4286 µM -0.746249725147452 0.214739662963332 no 2665 0.227758287615331 3732 17741321 SGTC_2832 7992762 51.95 µM -0.747286619942217 0.214424774694409 no 2666 0.227445283653906 3710 2985177 SGTC_1328 1441-0025 69.2 µM -0.747602701523239 0.214328839229479 no 2667 0.227349917374312 3704 4562601 SGTC_1632 st005650 90 µM -0.749281706931051 0.21381965478918 no 2668 0.226843715562917 3783 2759605 SGTC_2486 5283202 22.39 µM -0.749541256745151 0.213741005194182 no 2669 0.226765520905398 3786 1377751 SGTC_158 k038-0087 26.446 µM -0.750266098537616 0.21352145062801 no 2670 0.226547228143115 3699 X158 SGTC_413 propylparaben 100 µM -0.750477489326546 0.213457445123655 no 2671 0.226483588216385 3716 7175 A pharmaceutical preservative. SGTC_2420 aureobasidin a 50 nM -0.753342340423327 0.212591120680166 no 2672 0.225622110910797 3808 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1016 4226-1401 38 µM -0.756492279853257 0.211640960453471 no 2673 0.224677049680414 3760 2901613 SGTC_2800 7887935 81.82 µM -0.759082593726495 0.210861473759767 no 2674 0.223901575427052 3771 2961002 SGTC_786 4544-0069 423 µM -0.760090066445032 0.210558756717509 no 2675 0.223600374983796 3817 748821 YLR208W SEC13 SGTC_1891 st059073 26.2 µM -0.760357520373429 0.210478437239298 no 2676 0.223520453981244 3772 688754 SGTC_1312 1218-2183 165 µM -0.760462245766466 0.210446991904266 no 2677 0.223489164202349 3775 6744073 SGTC_2450 5739737 12.93 µM -0.760796258496682 0.210346718108995 no 2678 0.223389384763164 3791 2262825 SGTC_184 1494-0393 24.714 µM -0.760861147988485 0.210327240921751 no 2679 0.223370003301869 3759 3090647 SGTC_3113 9123498 49.47 µM -0.760996102767013 0.210286736375559 no 2680 0.223329697516005 3802 8897275 SGTC_2850 9015429 58.44 µM -0.761004481245353 0.21028422185858 no 2681 0.223327195324224 3831 6457570 SGTC_1950 st077106 7.18 µM -0.761180153337849 0.21023150388607 no 2682 0.223274735382949 3790 13831864 SGTC_2922 7999257 32.47 µM -0.76154792046778 0.210121164666163 no 2683 0.22316493392526 3746 2988377 SGTC_409 arachidonic acid 100 µM -0.761872552194272 0.210023795406372 no 2684 0.223068036629259 3777 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3071 9117417 49.47 µM -0.76187788507663 0.210022196095823 no 2685 0.223066445050562 3710 45595590 YGL055W OLE1 SGTC_1885 st057546 99.9 µM -0.761890788458826 0.210018326451603 no 2686 0.223062594111395 3842 702008 SGTC_1218 1348-1416 30.7 µM -0.764681967661654 0.209182254210203 no 2687 0.222230473228087 3738 6787668 SGTC_3124 9127567 49.47 µM -0.764779593533387 0.209153046782739 no 2688 0.222201400591139 3718 17592030 SGTC_1733 st037357 54.9 µM -0.765132817878388 0.209047390201147 no 2689 0.222096229773849 3716 1272339 YGL099W LSG1 SGTC_1399 3562-5772 25 µM -0.765225004466045 0.209019820492 no 2690 0.222068786345539 3726 23847490 SGTC_457 grayanotoxin iii 135 µM -0.7707710950115 0.207365126383227 no 2691 0.220421311511198 3716 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1969 st069479 40.1 µM -0.770897645243763 0.20732746030786 no 2692 0.220383801495756 3774 3895485 SGTC_1727 st034309 9.9045 µM -0.771126949876327 0.207259220992106 no 2693 0.220315843970791 3884 870305 SGTC_1186 1319-0216 26 µM -0.771180824243197 0.207243190317103 no 2694 0.220299879317573 3853 4565136 SGTC_2864 9034755 47.6 µM -0.771182425236317 0.207242713942206 no 2695 0.220299404903585 3770 4930451 SGTC_268 camptothecin 39.6153 µM -0.771391541079708 0.207180497168631 no 2696 0.220237443725199 3781 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_675 1309-0189 238 µM -0.771541504529802 0.207135886395555 no 2697 0.220193015597887 3813 4246530 SGTC_3213 9129884 49.47 µM -0.774443624080001 0.2062736902297 no 2698 0.219334247256361 3784 17190742 SGTC_1992 st073643 23.3 µM -0.774717397820718 0.206192464218118 no 2699 0.219253334136637 3767 3161292 SGTC_1816 st051957 91.6 µM -0.775715868249427 0.205896388455427 no 2700 0.218958384218513 3781 674121 SGTC_1880 MG-132 525 µM -0.776272266397694 0.205731509574057 no 2701 0.218794122303383 3726 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2380 9035439 200 µM -0.777489312054319 0.205371132588942 no 2702 0.218435068886849 3912 6462575 SGTC_3335 9143315 29.6265 µM -0.778051005764561 0.205204937104875 no 2703 0.218269472246614 3802 4899691 SGTC_1085 doxorubicin 7.67 µM -0.778110490318286 0.205187341331801 no 2704 0.218251939448249 3791 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_560 2332-1943 155 µM -0.779126579709617 0.204886916426733 no 2705 0.217952577118124 3772 21177716 SGTC_1309 pyrazolanthrone 13.4 µM -0.781379255978951 0.204221806011041 no 2706 0.217289734013498 3803 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_3336 9143619 71.43 µM -0.78200694966844 0.204036706592349 no 2707 0.217105244670775 3810 45595730 SGTC_1196 1588-0294 184 µM -0.783319613579767 0.203649940798269 no 2708 0.216719724157287 3829 6144269 SGTC_1024 4507-0395 26 µM -0.783548764243766 0.203582468257066 no 2709 0.216652464769077 3879 4201836 SGTC_377 3970-0964 33.1 µM -0.785132002538938 0.203116654143223 no 2710 0.216188088991211 3792 16481235 SGTC_329 k048-0121 21.3 µM -0.787386474172737 0.202454451671986 no 2711 0.215527831097506 3813 6832902 SGTC_685 1278-0033 54.9 µM -0.787914526535042 0.202299534453241 no 2712 0.215373351774323 3838 3590572 SGTC_1355 1499-0035 1.68 µM -0.788311401359575 0.202183148092899 no 2713 0.215257290141219 3805 1548538 SGTC_2732 terfenadine 20 µM -0.788996175315779 0.201982427484501 no 2714 0.215057120972356 3812 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2939 9044578 71.43 µM -0.789428345540725 0.201855811372138 no 2715 0.214930847115221 3786 2653634 SGTC_1775 st081588 35.1725 µM -0.79130827695427 0.201305587148381 no 2716 0.2143820598064 3843 1426443 YGL099W LSG1 SGTC_2881 9058953 51.95 µM -0.791577883372448 0.201226751679039 no 2717 0.214303423494505 3801 17122249 SGTC_175 3793-3120 23.7 µM -0.79175590941144 0.201174705328389 no 2718 0.214251507700761 3831 5322297 SGTC_1202 1988-0068 29.6 µM -0.791782896086574 0.201166816412126 no 2719 0.214243638509429 3789 2850480 SGTC_2705 st078069 42.8 µM -0.792960411707017 0.20082277823536 no 2720 0.21390044408628 3856 1530061 SGTC_1271 0832-2808 169 µM -0.794284259375368 0.20043640774176 no 2721 0.21351498274352 3867 3663794 SGTC_393 acivicin 6.25 µM -0.795135517985182 0.200188200373201 no 2722 0.213267337928072 3695 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_813 k007-0158 173 µM -0.795228862925621 0.200160994385333 no 2723 0.21324019257763 3840 6523916 SGTC_2204 7233102 200 µM -0.795244500035967 0.200156437065498 no 2724 0.213235645395474 3730 2172480 SGTC_653 0203-0016 55.2 µM -0.795268135593597 0.200149548775895 no 2725 0.213228772417973 3862 295302 SGTC_936 3005-4620 401 µM -0.795768853212103 0.200003654331605 no 2726 0.213083199235577 3824 777207 SGTC_2751 anetholtrithion 17.25 µM -0.796931696037328 0.199665082758886 no 2727 0.212745350737775 3830 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2333 9017922 200 µM -0.797001210573591 0.199644853940639 no 2728 0.212725164126259 3872 3163164 SGTC_2008 4012253 172 µM -0.797941025417072 0.19937148768581 no 2729 0.212452357219898 3838 603940 SGTC_1153 4055-0057 267 µM -0.797967973698278 0.199363652498193 no 2730 0.212444537761502 3860 882706 SGTC_1607 st000305 50.6 µM -0.798051467676927 0.1993393778789 no 2731 0.212420311766585 3809 5457690 SGTC_1699 st031318 29.054 µM -0.801501916458894 0.198337768940101 no 2732 0.211420567520115 3899 5340658 SGTC_1313 1220-0047 237 µM -0.801666520096441 0.198290063215022 no 2733 0.211372943692115 3824 3528706 SGTC_262 fenpropimorph 62.5 µM -0.801873796968347 0.198229999707995 no 2734 0.211312982400302 3786 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.803456163937026 0.197771832492167 no 2735 0.210855561954463 3864 688664 SGTC_3221 9128209 49.47 µM -0.803846949004289 0.197658781041702 no 2736 0.210742685797551 3875 16460723 SGTC_3049 9092223 49.47 µM -0.804327938322022 0.197519687752968 no 2737 0.2106038033025 3815 8623917 SGTC_1296 1068-0102 11.9 µM -0.80451497218844 0.197465616972821 no 2738 0.210549813011628 3860 767053 SGTC_117 lucigenin 22.078 µM -0.804874039160053 0.197361837163305 no 2739 0.210446185405503 3865 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1671 st016596 74.5 µM -0.805104870404452 0.197295138278547 no 2740 0.210379582756294 3894 2829167 SGTC_642 0335-0876 158 µM -0.805229784541949 0.197259049918465 no 2741 0.210343545948487 3857 6812350 SGTC_23 0213-0011 39.996 µM -0.805433737797259 0.197200135319484 no 2742 0.210284714728252 3840 627608 SGTC_3141 9094609 49.47 µM -0.808122994666289 0.196424303882658 no 2743 0.209509890754394 3818 25236309 YDL196W YDL196W SGTC_1483 3453-0561 55.9 µM -0.808282590836539 0.196378319748654 no 2744 0.209463961040088 3853 4546991 SGTC_1061 3448-9325 110 µM -0.808349205517209 0.196359128120641 no 2745 0.209444791948767 3755 723482 SGTC_1212 0520-0165 585 µM -0.810249124781051 0.195812241854998 no 2746 0.208898504381495 3928 5403258 SGTC_483 fpl-64176 144 µM -0.811380720191404 0.195486955074081 no 2747 0.208573533750271 3871 3423 SGTC_1485 3909-9022 254 µM -0.811500979390326 0.195452404840972 no 2748 0.208539015342352 3884 714516 SGTC_691 1548-0686 185 µM -0.811864362218015 0.195348028201189 no 2749 0.208434732798193 3865 46495133 SGTC_882 0843-0131 351 µM -0.812744329007439 0.195095410361845 no 2750 0.208182329941597 3820 5425421 SGTC_2323 6148992 148.28 µM -0.813578072809611 0.194856245350125 no 2751 0.207943351809276 3837 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1864 st057645 30.4 µM -0.814389523810888 0.194623646481982 no 2752 0.207710919125659 3883 688666 SGTC_1054 3429-0080 167 µM -0.814420777506452 0.194614691127503 no 2753 0.207701969862329 3858 1162877 SGTC_729 4092-0585 94.1 µM -0.814771505416615 0.194514211639814 no 2754 0.207601557154991 3861 2169061 SGTC_2908 7930301 100 µM -0.816640684840757 0.193979246092012 no 2755 0.207066898773224 3864 2223178 SGTC_576 1073-0113 22.7 µM -0.81689565845349 0.193906341323715 no 2756 0.206994029547723 4006 5439563 SGTC_1739 st037196 92.5 µM -0.817437845736878 0.193751368886021 no 2757 0.206839127619517 3900 612214 SGTC_1219 1469-0211 33.1 µM -0.817938105770082 0.193608447437603 no 2758 0.206696265112243 3849 6822282 SGTC_3224 9130643 49.47 µM -0.818221421610807 0.193527534236434 no 2759 0.20661538268893 3865 17644395 SGTC_2162 5663267 200 µM -0.819418420072911 0.193185906811781 no 2760 0.206273864535163 3828 6456493 SGTC_395 anisomycin 6.25 µM -0.823083448920066 0.192142186368575 no 2761 0.205230270099732 3873 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2522 biochanin a 4.94 µM -0.823764165944203 0.191948713553337 no 2762 0.205036786110289 3849 5280373 A possible chelator. SGTC_2146 5545642 200 µM -0.82520754604262 0.191538871934588 no 2763 0.204626885011479 3846 825326 SGTC_337 1315-0038 354 µM -0.825758995497714 0.191382431852837 no 2764 0.204470409373152 3839 1626437 SGTC_1386 3228-0095 33.8 µM -0.827377984622603 0.190923595223266 no 2765 0.204011427400375 3886 870181 SGTC_2079 5212404 121 µM -0.8291278835222 0.190428417123717 no 2766 0.203516023565039 3809 758462 SGTC_2181 6316240 54.2555 µM -0.830314116624406 0.190093191457193 no 2767 0.203180604367781 3897 12779990 SGTC_1019 4262-0212 3.4 µM -0.832508729426206 0.189473957777581 no 2768 0.202560926461207 3913 4677213 SGTC_1913 st060213 96.1 µM -0.832894502861026 0.189365236058974 no 2769 0.202452115104025 3916 688959 SGTC_945 3381-0768 11.3 µM -0.833162971004316 0.189289596909558 no 2770 0.202376411536419 3937 1126236 YIL048W NEO1 SGTC_1412 3909-8563 178 µM -0.834057101122251 0.189037815732898 no 2771 0.202124403766288 3951 23767530 SGTC_3017 9080681 49.47 µM -0.835944691408719 0.188506960512579 no 2772 0.201593009370399 3915 16451914 SGTC_270 tamoxifen 5.46 µM -0.835998262839139 0.188491907813947 no 2773 0.201577940165919 3919 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2471 5466956 24.79 µM -0.837024266441327 0.188203760586781 no 2774 0.201289464007621 3849 724419 SGTC_2432 5630864 12.22 µM -0.83781372773296 0.187982230051773 no 2775 0.201067663808154 3925 5714970 SGTC_1158 4092-0494 91.8 µM -0.838651017335125 0.187747454412653 no 2776 0.200832586433506 3987 1148199 SGTC_2519 cryptotanshinone 88.04 µM -0.841612625478007 0.186918475014619 no 2777 0.200002409947511 3850 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_2393 9031399 185.94 µM -0.841629038452386 0.186913887202768 no 2778 0.199997814938131 3924 1526623 YDL150W RPC53 SGTC_2030 5175110 200 µM -0.842175714785164 0.186761118139761 no 2779 0.199844802598213 3951 2831986 SGTC_2937 9044753 11.33 µM -0.842941261682755 0.186547315491161 no 2780 0.199630647709151 3861 6465530 YGL099W LSG1 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.843567659804356 0.186372487239388 no 2781 0.199455521209973 3891 6857784 SGTC_2994 9053520 71.4286 µM -0.843681993476261 0.186340587571293 no 2782 0.199423566130109 3952 4647384 SGTC_2841 9004761 38.96 µM -0.84795186078147 0.185151696186896 no 2783 0.198232390356728 3920 2991039 SGTC_220 paclitaxel 373.376 µM -0.848463089999446 0.185009667267274 no 2784 0.198090059893429 3850 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1151 3909-8316 15.3 µM -0.849027671769346 0.184852894702277 no 2785 0.197932947358893 3944 800431 SGTC_2968 9090663 33.37 µM -0.850436031021023 0.184462182756947 no 2786 0.197541355551846 3889 25236811 SGTC_856 0433-0016 11.3 µM -0.850798883263171 0.18436160230243 no 2787 0.197440541057234 3953 3911780 SGTC_1804 st050076 49.1 µM -0.851457689446088 0.184179072435303 no 2788 0.197257578566114 3934 3895976 SGTC_2998 9066762 71.4286 µM -0.852563306365855 0.183873001365596 no 2789 0.196950759177071 3926 4945196 SGTC_1478 0453-0656 35.7 µM -0.852847761610887 0.183794306077315 no 2790 0.196871866845431 3915 5258496 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.853277138237926 0.183675557651968 no 2791 0.196752817491594 3885 6312947 SGTC_2984 9022109 38.96 µM -0.853886978368953 0.183506982413158 no 2792 0.196583807617468 3929 6459207 SGTC_505 gw-5074 63.9 µM -0.855789513348143 0.182981693591425 no 2793 0.196057108374925 3960 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2704 st078022 71.1 µM -0.858735852813158 0.182170064676716 no 2794 0.195243132655762 3948 54697681 SGTC_2836 9010338 19.48 µM -0.860103924177239 0.181793967889727 no 2795 0.194865879132253 3927 2994051 SGTC_2485 5633444 17.78 µM -0.861165315075164 0.181502515545806 no 2796 0.194573500111985 3948 5724239 SGTC_2262 9014885 67.46 µM -0.861555759232973 0.18139537526368 no 2797 0.194466012518124 3854 6457424 SGTC_1226 3909-7979 35.4 µM -0.862335206804176 0.18118160850108 no 2798 0.194251542086888 3941 6615510 SGTC_2054 5233173 129 µM -0.862530191378362 0.181128157847788 no 2799 0.194197913254836 3951 6889 SGTC_974 1326-0144 138 µM -0.863472906804909 0.180869872882556 no 2800 0.193938754692813 3956 5411856 SGTC_298 1391-0729 10 µM -0.863681586432699 0.18081273010499 no 2801 0.193881415818389 3875 3237558 SGTC_139 0099-0334 718.624 µM -0.864522464390047 0.180582587045396 no 2802 0.193650472608075 3961 97690 SGTC_1066 ketoconazole 628 nM -0.865782345195374 0.180238109522171 no 2803 0.193304766330798 3992 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_1697 st025554 27.742 µM -0.867076168724572 0.179884780889606 no 2804 0.192950138558619 3894 1269519 SGTC_1378 2093-0007 380 nM -0.867910256956527 0.179657231574195 no 2805 0.192721731721328 4004 3618014 SGTC_1618 st003135 44.5 µM -0.868225485515054 0.179571280543374 no 2806 0.192635452524758 3836 1270615 SGTC_3067 9117431 49.47 µM -0.868613998181001 0.17946538323944 no 2807 0.192529147685092 3976 17150885 SGTC_781 4335-2806 94.4 µM -0.868828968358908 0.179406805466988 no 2808 0.192470342956513 4033 845254 SGTC_3350 9150499 3.57 µM -0.870422121861154 0.178973057729935 no 2809 0.192034880836346 3903 4910996 YPR165W RHO1 SGTC_2378 9074213 121.43 µM -0.871909360489501 0.178568742168779 no 2810 0.191628913387868 3902 657714 SGTC_1361 1608-0041 5.61 µM -0.873449045418246 0.178150775282182 no 2811 0.191209184066593 3886 X1361 SGTC_3284 9108171 64.8615 µM -0.874751016046862 0.177797820564267 no 2812 0.190854697559974 3922 8687505 SGTC_2762 leflunomide 42.06 µM -0.874812841832329 0.177781071023937 no 2813 0.190837874336639 3906 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_26 0302-0163 425.158 µM -0.876246443624426 0.177392965785915 no 2814 0.190448036573181 3988 3100915 SGTC_2666 tannic acid 100 µM -0.8768748783105 0.177223004465919 no 2815 0.190277301296206 3946 16134267 A thiamine antagonist. SGTC_891 0929-0073 133 µM -0.877292852296308 0.17711001959865 no 2816 0.190163796782166 4011 5603632 SGTC_2352 9027995 87.8 µM -0.881271033783386 0.176036933812818 no 2817 0.189085570077441 3906 2997347 SGTC_1238 0333-0287 48.8 µM -0.883962572168761 0.175313250438437 no 2818 0.188358208732856 3937 7226 SGTC_271 rotenone 740 µM -0.886249865647867 0.174699742701085 no 2819 0.187741449071075 3966 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_449 xestospongin c 11.1929 µM -0.886497880920275 0.174633300982448 no 2820 0.187674647775767 3965 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1524 corynanthine 62.1 µM -0.887945982279387 0.174245684207842 no 2821 0.187284904349942 4094 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1383 3049-0032 20.7 µM -0.889042039704345 0.173952663681797 no 2822 0.186990243358597 4030 712864 SGTC_2883 9059145 45.46 µM -0.890206617538385 0.173641668400801 no 2823 0.186677475997758 3934 16476510 SGTC_834 0312-0008 75.7 µM -0.890347441359879 0.173604086021338 no 2824 0.186639677306161 3945 6385573 YIL048W NEO1 SGTC_1539 benzyladenosine 56 µM -0.890561909568855 0.173546859728867 no 2825 0.186582120740242 3941 92208 A nucleotide analog. SGTC_254 nsc-64875 3.808 µM -0.890568293447115 0.173545156510366 no 2826 0.186580407675253 3988 56993 SGTC_1783 st039459 87.517 µM -0.891980991971196 0.173168510246126 no 2827 0.186201560380946 4064 729761 SGTC_2923 7992654 58.14 µM -0.893790302345367 0.172686882383865 no 2828 0.185717049401436 3978 2985126 SGTC_3041 9091929 49.47 µM -0.89538464605666 0.172263185895419 no 2829 0.1852907527216 3964 25236887 SGTC_580 1123-0028 41 µM -0.895584331796889 0.172210166233405 no 2830 0.185237403463924 4022 1677248 YPR107C YTH1 SGTC_4 0960-0234 25.671 µM -0.895838250937101 0.172142761803583 no 2831 0.18516957865928 3962 6821112 SGTC_458 nppb 133 µM -0.897179082811493 0.171787108825191 no 2832 0.184811682438132 3967 4549 A chloride channel blocker. SGTC_2531 methyl deoxycholate 70.07 µM -0.898960464080785 0.171315327467593 no 2833 0.184336859905568 3921 16667744 Haematoxylin. SGTC_1893 st059353 36.1 µM -0.899916194129396 0.171062553473904 no 2834 0.18408242569375 3983 3112488 SGTC_281 1672-3440 14.9 µM -0.89998129855474 0.171045343167543 no 2835 0.184065101567373 4018 6833000 SGTC_2572 astragaloside iv 100 µM -0.900056933877325 0.171025350417141 no 2836 0.184044976469913 4052 45006101 An anti-inflammatory agent. SGTC_2110 5483698 200 µM -0.90012545227454 0.171007240180301 no 2837 0.18402674623143 3959 2848765 YHR062C RPP1 SGTC_2440 5628896 157.78 µM -0.900447860346234 0.170922040315338 no 2838 0.183940980332356 3970 5522048 SGTC_474 dl-dihydrosphingosine 5 µM -0.900976428280353 0.170782419219734 no 2839 0.183800426351612 3967 3058739 A sphingolipid protein kinase C inhibitor. SGTC_325 2810-4341 181 µM -0.90375757814726 0.170048982005515 no 2840 0.183061980302179 3979 774970 SGTC_1701 st028638 40.4 µM -0.906138468103581 0.169422706610161 no 2841 0.18243128328155 3953 3490878 SGTC_1459 k035-0031 35.7 µM -0.906489444968227 0.169330510099543 no 2842 0.18233842455391 3803 3877128 YMR208W ERG12 SGTC_1712 st032288 53.4 µM -0.909459939789093 0.168551494398623 no 2843 0.181553697303648 3902 2883011 SGTC_2115 tiliquinol 12.7705 µM -0.909855925957122 0.168447820886462 no 2844 0.181449247984485 3969 71208 A bioactive hydroxyquinoline. SGTC_1990 st072050 59.8 µM -0.91051629786576 0.168275019523915 no 2845 0.181275145301235 3969 17233948 SGTC_1558 st069300 45.6 µM -0.911629842048062 0.167983893653218 no 2846 0.180981803773672 3905 24208000 SGTC_840 0245-0196 390 µM -0.912177111319894 0.167840934023379 no 2847 0.180837745421509 4085 3827528 SGTC_359 0081-0058 15.9 µM -0.915897132396687 0.166871253438714 no 2848 0.179860425496537 4057 3494159 SGTC_2787 5284540 71.43 µM -0.915958488483919 0.166855290386247 no 2849 0.179844333951559 4045 736958 SGTC_288 1315-0019 35.1 µM -0.916704853888386 0.166661186900014 no 2850 0.179648660952095 4061 6811474 SGTC_1445 4239-0156 97.7 µM -0.916704938901485 0.166661164799389 no 2851 0.179648638672018 4097 4008346 SGTC_166 k072-0058 166.424 µM -0.916749623825847 0.166649548442567 no 2852 0.179636927969197 3914 5846229 SGTC_3292 9120825 59.784 µM -0.919444870999796 0.165949854466959 no 2853 0.178931464255665 3984 24824900 SGTC_924 2046-0044 21.3 µM -0.921759052921984 0.165350603259825 no 2854 0.178327135124114 3988 3623589 SGTC_3169 9102970 49.47 µM -0.922954762430386 0.165041526787199 no 2855 0.178015390186945 4048 17027839 SGTC_527 4476-4215 268 µM -0.924707409035583 0.164589165205344 no 2856 0.177559062218127 3975 4418754 SGTC_2544 sphondin 68.51 µM -0.92859790637963 0.163587894246078 no 2857 0.176548753642057 3998 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_733 4069-0007 56.1 µM -0.929214493430301 0.163429571257658 no 2858 0.176388968889249 3997 5717425 YNL287W SEC21 SGTC_728 3030-5151 22.5 µM -0.935038198249098 0.161939111592272 no 2859 0.174884307104516 4046 3125388 SGTC_1503 4585-0012 61.3 µM -0.935082346062195 0.161927846775066 no 2860 0.174872931899331 4081 2922052 SGTC_630 4356-0227 183 µM -0.938446070420378 0.161071055492671 no 2861 0.174007609721798 3985 779312 SGTC_1181 1222-0449 220 µM -0.940483696448777 0.160553482908905 no 2862 0.173484754287023 4068 658318 SGTC_2760 etidronate 98.04 µM -0.942180513877714 0.160123308279556 no 2863 0.173050114304568 3984 3305 A chelator and antioxidant. SGTC_3091 9116372 49.47 µM -0.943832788448374 0.159705150892038 no 2864 0.172627551186549 4103 17169793 SGTC_3203 9113543 49.47 µM -0.945644735360431 0.15924740583878 no 2865 0.17216490944595 4122 17018012 SGTC_2772 vinpocetine 57.06 µM -0.946892592943732 0.15893266459301 no 2866 0.171846756352108 4041 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1074 carmofur 3.8 µM -0.947361906012115 0.158814397526989 no 2867 0.171727197764816 4051 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2202 7226349 200 µM -0.947743260999079 0.158718338422738 no 2868 0.171630085839497 3978 844334 SGTC_2981 9013952 38.96 µM -0.948260370083896 0.158588145219251 no 2869 0.171498460231111 4005 2996344 SGTC_1935 st074532 41.6 µM -0.952750693395547 0.157460556101094 no 2870 0.170358200912542 4020 2829742 SGTC_2614 arthonioic acid 13.39 µM -0.956173599107572 0.156604559777558 no 2871 0.169492267926917 3923 6710684 SGTC_2821 7996764 71.43 µM -0.963504337152367 0.154781622132623 no 2872 0.167647244329664 4090 2987135 SGTC_233 rapamycin 362 pM -0.964481729949184 0.154539636905405 no 2873 0.167402231936237 4036 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3275 9138069 49.47 µM -0.966358062775631 0.154075791132806 no 2874 0.166932520662224 4134 17617007 SGTC_2647 atorvastatin 60.16 µM -0.96815491565037 0.153632457715498 no 2875 0.166483503589507 4024 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2384 9036245 200 µM -0.968922793236452 0.153443258883378 no 2876 0.166291856034086 3998 6462766 SGTC_3298 9116858 71.43 µM -0.969703367678459 0.153251089895088 no 2877 0.16609718567653 4122 2506942 SGTC_1962 st076595 64.5 µM -0.969975914506324 0.153184029390414 no 2878 0.166029248904699 4051 279619 SGTC_613 3914-0030 117 µM -0.970893614773485 0.152958371034913 no 2879 0.165800629077789 3776 1145395 SGTC_3237 9133362 49.47 µM -0.970949277479031 0.152944690919697 no 2880 0.165786768792144 4010 43845137 SGTC_2174 5790901 200 µM -0.972593924851624 0.152540855198993 no 2881 0.165377581607644 4081 786020 SGTC_1112 tnp00069 1.16933 µM -0.973083912254891 0.152420677927555 no 2882 0.165255799509295 4071 145826 SGTC_610 4215-0184 155 µM -0.974019715600593 0.152191331794704 no 2883 0.1650233750534 4088 5605015 SGTC_1717 st033143 58.0435 µM -0.974756996389976 0.152010800912428 no 2884 0.16484040656549 4125 674616 SGTC_1400 3771-8998 51.5 µM -0.977784030623424 0.151271091385084 no 2885 0.16409057544429 3970 670767 SGTC_2315 7733312 200 µM -0.97794876353844 0.151230904784138 no 2886 0.164049832788925 3974 726316 SGTC_103 0844-0104 51.839 µM -0.982047466029814 0.150233312687471 no 2887 0.163038232274146 3997 5375804 SGTC_2556 citropten 84.59 µM -0.982051733766565 0.15023227624476 no 2888 0.163037181072 4100 2775 A potential DNA crosslinker. SGTC_819 1013-0258 27.7 µM -0.987520815890128 0.148907995957191 no 2889 0.161693691716524 4091 5753198 SGTC_3185 9108267 49.47 µM -0.987596963868931 0.148889612756901 no 2890 0.161675036912096 4080 4910486 SGTC_699 0375-0592 111 µM -0.98961344192203 0.148403358175672 no 2891 0.161181548651788 4148 762578 SGTC_2611 pyromycin 23.93 µM -0.98986413472873 0.14834298029429 no 2892 0.16112026590524 4061 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_2389 9091542 195.52 µM -0.99671043257032 0.146700441108886 no 2893 0.159452542156729 4073 3626624 YOL127W RPL25 SGTC_861 0443-0273 110 µM -0.997299025229318 0.146559799957063 no 2894 0.159309693372797 4085 6149169 SGTC_3200 9114385 49.47 µM -0.998528218894729 0.146266382444201 no 2895 0.159011643942925 4136 17018030 YLR208W SEC13 SGTC_2123 5259487 200 µM -0.999241516107301 0.146096294187738 no 2896 0.158838854431117 4100 2173474 SGTC_348 k064-0012 10.7 µM -0.999591926655157 0.146012786234288 no 2897 0.158754015881314 3991 5066323 SGTC_2591 skatole 100 µM -1.00023994457068 0.145858438604325 no 2898 0.158597201335383 4127 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1504 k297-0033 30 µM -1.00094091824163 0.145691601252501 no 2899 0.158427686374425 3986 4388117 SGTC_2153 5569715 200 µM -1.00449022951026 0.144848806637097 no 2900 0.157571189161772 4124 2054701 SGTC_2771 fluoxetine 41.05 µM -1.00745377243149 0.144147624157543 no 2901 0.156858380945944 4112 3386 A selective serotonin reuptake inhibitor. SGTC_1183 1254-0324 198 µM -1.00764315067441 0.144102894667057 no 2902 0.156812902849369 4177 5799357 SGTC_1777 st045864 34.765 µM -1.00785002934933 0.144054042424477 no 2903 0.156763232042086 4080 4691462 SGTC_1165 k072-0275 30.3 µM -1.00830065175207 0.143947671302999 no 2904 0.156655075108069 4065 6153523 YGL055W OLE1 SGTC_677 0929-0063 136 µM -1.00905072969017 0.143770730083599 no 2905 0.156475152777438 4065 1539583 SGTC_757 1066-0008 322 µM -1.00978165544547 0.143598448042733 no 2906 0.156299955466307 4125 6842497 SGTC_2339 9000433 200 µM -1.01359485329196 0.142701922703617 no 2907 0.155388057262788 4127 2988954 SGTC_202 3594-0513 34.79 µM -1.01637780692507 0.1420500129331 no 2908 0.154724754891166 4119 708429 SGTC_1213 1315-0166 115 µM -1.02012947680827 0.141174375604845 no 2909 0.153833529311868 4200 768401 SGTC_1658 st012944 20 µM -1.02119452290118 0.140926462901864 no 2910 0.153581143386292 3978 24207260 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.02128039559569 0.140906487032919 no 2911 0.153560805928528 4056 4330530 SGTC_661 1304-0007 33.6 µM -1.02600091103161 0.139811346163581 no 2912 0.152445577320167 4121 3117130 SGTC_3097 9117246 49.47 µM -1.03080400433733 0.138703000852359 no 2913 0.151316370040944 4131 16423892 SGTC_306 1672-3436 11.6 µM -1.03335330956829 0.138117169718594 no 2914 0.150719294016171 4171 6797378 SGTC_2563 tomatine 8.54 µM -1.0353518403146 0.137659088209428 no 2915 0.150252314022566 4058 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_161 4065-0411 162.148 µM -1.03679031083276 0.137330020066437 no 2916 0.149916796050079 4139 1906281 YLR208W SEC13 SGTC_2248 tofa 1.1 µM -1.03685542547702 0.1373151369957 no 2917 0.149901620127804 4092 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1574 spiramycin 23.7 µM -1.03841595246945 0.136958781255177 no 2918 0.149538222938345 4093 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1803 st050068 52.4 µM -1.04195607478852 0.136152717679384 no 2919 0.148716022179775 4188 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_3239 9133757 49.47 µM -1.04488886960246 0.135487402521481 no 2920 0.148037167299099 4158 17036923 SGTC_291 SEC14.278 35.5 µM -1.04712049210671 0.134982645749085 no 2921 0.147522004600482 4186 1068044 SGTC_3028 9087778 49.47 µM -1.0477730852155 0.134835283830429 no 2922 0.147371582867023 4116 17217395 SGTC_2303 7774051 200 µM -1.04867341953636 0.134632160754048 no 2923 0.147164225930635 4192 2953184 SGTC_2189 6047310 154.431 µM -1.05046784798252 0.134227949106296 no 2924 0.146751532896182 4128 711535 SGTC_1130 3454-2858 15.9 µM -1.05167192799541 0.133957186685374 no 2925 0.146475047335467 4181 715628 YIL048W NEO1 SGTC_1689 st020265 53.493 µM -1.05278453886052 0.133707326856428 no 2926 0.146219876310161 4148 5758320 YPR016C TIF6 SGTC_1339 1486-1321 22.7 µM -1.05366896834527 0.133508938600286 no 2927 0.146017250503676 4158 3469382 SGTC_1795 st049545 62.3 µM -1.06044462056412 0.131995794267961 no 2928 0.144471185820176 4108 5291882 SGTC_2885 9057732 51.95 µM -1.06274041029607 0.131485789664867 no 2929 0.143949844822706 4225 6471414 SGTC_2144 5628481 200 µM -1.06405865424802 0.131193560269123 no 2930 0.143651064683028 4127 2818399 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -1.06424696004207 0.131151853131746 no 2931 0.143608419340151 4154 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_129 0088-0017 176.636 µM -1.06546289523483 0.130882760757238 no 2932 0.143333253978437 4015 182446 SGTC_1136 pergolide 1.05886 µM -1.06786291433413 0.13035274526259 no 2933 0.142791176685601 4127 47811 A dopamine receptor agonist. SGTC_573 3702-0553 84.7 µM -1.07083682826164 0.129698054147569 no 2934 0.14212140215718 4116 1222756 SGTC_1301 naphtanilide LB 4.81 µM -1.07378246635863 0.129051836216499 no 2935 0.141460095094226 4226 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_2733 amorolfine 100 µM -1.07454543521535 0.128884819766614 no 2936 0.141289146210282 4288 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3216 9129716 49.47 µM -1.07563277154799 0.128647057359475 no 2937 0.141045762455053 4123 8056934 SGTC_1078 idebenone 36.1 µM -1.07579778235432 0.128611001886545 no 2938 0.141008852151058 4216 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_89 0302-0250 142.109 µM -1.07594260952744 0.128579362391155 no 2939 0.140976462004768 4264 4203518 YLR208W SEC13 SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.07912662643483 0.127885134502905 no 2940 0.140265641484285 4221 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_1676 st018489 23.4 µM -1.07925247317911 0.127857749087767 no 2941 0.140237596739124 4197 3696235 SGTC_1344 1488-0097 29.1 µM -1.07966502659013 0.127768002229247 no 2942 0.14014568658169 4204 747966 SGTC_1440 4100-1550 40 µM -1.08037592365545 0.127613456445003 no 2943 0.139987406362435 4171 742806 SGTC_2488 5268135 45.7 µM -1.08073768455031 0.127534861188519 no 2944 0.139906907468336 4230 1270356 YLR208W SEC13 SGTC_2873 9040596 71.43 µM -1.08154601852511 0.127359366236348 no 2945 0.139727151009535 4161 6463863 SGTC_2015 5119600 184 µM -1.0815564819416 0.127357095657267 no 2946 0.139724825195866 4207 2828786 SGTC_625 k213-0058 121 µM -1.08245920383614 0.127161309469774 no 2947 0.139524266788463 4232 3655420 SGTC_1207 2099-0101 141 µM -1.08332062485858 0.126974676151881 no 2948 0.139333066871538 4183 5837381 SGTC_633 0437-0093 97.7 µM -1.08627584475264 0.126335854958229 no 2949 0.138678485262105 4113 2831118 SGTC_2027 5150920 200 µM -1.0889683516872 0.125755776488605 no 2950 0.138083921126252 4127 786715 SGTC_1441 4106-0040 13 µM -1.09401097061341 0.124674389743852 no 2951 0.136975083365186 4181 2904180 SGTC_2154 5570129 200 µM -1.09550835599586 0.124354531524331 no 2952 0.136646993380952 4237 673366 SGTC_1148 3909-7663 27.7 µM -1.09676682173352 0.124086153399288 no 2953 0.136371668643985 4230 4084526 SGTC_2210 7115885 190.385 µM -1.09887649084243 0.123637158820447 no 2954 0.135910971116947 4267 2927039 SGTC_2999 9069765 71.4286 µM -1.10031082449465 0.12333254429673 no 2955 0.135598358729228 4150 2097066 SGTC_1267 0828-0272 9.49 µM -1.10067347958422 0.12325560930221 no 2956 0.135519396297176 4280 745334 SGTC_600 1495-0418 41.6 µM -1.10221384135509 0.122929206046732 no 2957 0.135184357947055 4181 5377768 SGTC_1232 0279-0259 161 µM -1.10358195990196 0.122639809796081 no 2958 0.134887260156552 4200 1560000 SGTC_969 1313-0238 134 µM -1.10439665275166 0.122467706138632 no 2959 0.134710556080044 4231 5212874 SGTC_2157 5649910 96.377 µM -1.10669102894505 0.121983930730482 no 2960 0.134213767671601 4190 2858091 SGTC_2796 7949634 45.45 µM -1.11248297185476 0.120768659488298 no 2961 0.132965273787044 4177 2971588 SGTC_2269 7935389 174.42 µM -1.11258042106449 0.120748285756782 no 2962 0.132944336546963 4177 97605 SGTC_1150 3909-7983 10.9 µM -1.11375115476416 0.120503709272792 no 2963 0.132692978508758 4186 23965914 SGTC_900 1112-0045 141 µM -1.11966306765014 0.119273988261849 no 2964 0.131428684476851 4086 56211 YIL048W NEO1 SGTC_1912 st060209 90.8 µM -1.12375011358741 0.118429047482327 no 2965 0.130559525081649 4212 688787 SGTC_1175 0741-0056 27.6 µM -1.12398241512918 0.118381149713063 no 2966 0.130510243024914 4300 765927 SGTC_2403 6032726 181.2 µM -1.12505066517144 0.118161065750487 no 2967 0.130283782676158 4271 2881040 SGTC_2628 lathosterol 100 µM -1.12966530819592 0.117213668773095 no 2968 0.129308640302183 4286 6710616 SGTC_1135 dihydrocapsaicin 536.708 nM -1.1299461007379 0.117156195577184 no 2969 0.129249468381613 4125 107982 A Capsaicinoid. SGTC_1437 4092-1038 11.6 µM -1.1313469063242 0.116869774041829 no 2970 0.128954554466527 4260 3977136 SGTC_1509 1326-1131 80 µM -1.13159755556731 0.11681857639821 no 2971 0.128901834129297 4182 768313 SGTC_2263 7948595 193.29 µM -1.13223219331381 0.116689016314865 no 2972 0.128768414377337 4223 2971371 SGTC_1433 4060-0023 7.6 µM -1.13608474925769 0.115904710687313 no 2973 0.127960548530655 4246 3840627 SGTC_141 0443-0274 32.331 µM -1.13723480017278 0.115671309746014 no 2974 0.127720071337156 4213 1627241 SGTC_2113 5491891 107.031 µM -1.13892288990051 0.115329319708285 no 2975 0.127367658753075 4226 789979 SGTC_2385 9074692 200 µM -1.14148385382789 0.114811867282606 no 2976 0.126834313651419 4258 17046906 SGTC_199 4063-0024 41.6 µM -1.14296166051363 0.114514023488337 no 2977 0.12652725481479 4241 306215 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.14411724792423 0.114281504691297 no 2978 0.126287507787012 4255 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2219 9098279 200 µM -1.14525078212644 0.11405375010253 no 2979 0.126052643844192 4172 902349 SGTC_824 1304-0008 100 µM -1.14590780134878 0.113921887080656 no 2980 0.12591665147281 4255 768245 SGTC_2502 avocadyne acetate 18.59 µM -1.14815528714516 0.113471640655042 no 2981 0.125452231945192 4178 3952079 SGTC_2639 lactacystin 53 µM -1.14942327137905 0.113218181715275 no 2982 0.125190744365699 4285 3870 A proteasome inhibitor. SGTC_114 0364-0001 490.298 µM -1.15041406332836 0.113020412387471 no 2983 0.124986685281293 4278 4003655 SGTC_2950 9072895 21.46 µM -1.1511961728476 0.112864471819401 no 2984 0.12482576967451 4216 17332245 SGTC_801 0866-0028 10.1 µM -1.1521302575968 0.112678431079647 no 2985 0.124633775588405 4262 6849771 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.15306117160162 0.112493239835281 no 2986 0.124442638685123 4129 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1862 st057513 3.81 µM -1.15376935881464 0.112352502404999 no 2987 0.124297369775992 4226 5393163 SGTC_1826 st055655 41.6 µM -1.15380685081216 0.112345055160976 no 2988 0.124289682430902 4263 676168 SGTC_521 r062-0005 13.8 µM -1.15519302984723 0.112069958271431 no 2989 0.124005694204016 4165 2832033 SGTC_2662 daunorubicin 22.37 µM -1.15645131648594 0.111820659788021 no 2990 0.123748300893801 4120 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_49 0717-0965 32.132 µM -1.15680713734573 0.111750234646896 no 2991 0.123675582578284 4327 5889349 YGL099W LSG1 SGTC_454 lyso-paf C-16 6.67 µM -1.15788820975613 0.111536460167815 no 2992 0.123454829791265 4276 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_620 0109-0052 432 µM -1.16033711689331 0.111053288584344 no 2993 0.122955789115461 4269 493037 SGTC_3112 9123419 49.47 µM -1.16208734909213 0.110708885935367 no 2994 0.122599992832071 4305 17015854 SGTC_3070 9117005 49.47 µM -1.16322163022951 0.110486096452067 no 2995 0.122369796370603 4335 8779016 SGTC_3218 9131285 49.47 µM -1.1646736408894 0.110201369540135 no 2996 0.12207556130649 4239 17156417 SGTC_1635 st007035 42.4 µM -1.16569915473686 0.110000592381329 no 2997 0.121868051024086 4228 3716403 SGTC_2241 6772625 37.8075 µM -1.16620480053218 0.109901692700531 no 2998 0.121765826063728 4093 2285411 SGTC_2680 butyl paraben 22.24 µM -1.16885500780943 0.109384380100259 no 2999 0.121231026693175 4346 7184 An antifungal and steroid mimetic. SGTC_2416 tofa 880 nM -1.16993246490628 0.109174564542672 no 3000 0.121014073933361 4251 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_480 am 92016 50 µM -1.17000370811259 0.109160701398614 no 3001 0.120999738300166 4257 2129 K+ channel blocker. SGTC_596 1155-0152 116 µM -1.170967579165 0.108973267012923 no 3002 0.120805904579273 4257 280313 SGTC_1778 st046819 58.9 µM -1.1715849666146 0.108853331447638 no 3003 0.120681863325371 4288 671715 SGTC_2728 chlorpromazine 9.18 µM -1.17215687174416 0.108742316117636 no 3004 0.120567040089499 4346 2726 A thorazine and dopamine antagonist. SGTC_1126 isoteolin 1.0172 µM -1.17693148795066 0.10781866797089 no 3005 0.119611426452275 4204 133323 SGTC_2268 7933382 153.85 µM -1.18232377272298 0.106782342301799 no 3006 0.11853862816758 4294 935025 YOR257W CDC31 SGTC_523 1934-0222 13.7 µM -1.18249555965294 0.106749445683396 no 3007 0.118504563180412 4214 1361595 SGTC_1306 1185-0270 9.02 µM -1.18282930144831 0.106685556161063 no 3008 0.118438402662253 4299 1548076 SGTC_1989 st071868 50.2 µM -1.18595591220519 0.106088356562229 no 3009 0.117819855415059 4273 16414057 SGTC_558 k064-0027 21.3 µM -1.19500145973001 0.104374217989461 no 3010 0.116043229896737 4283 5088526 SGTC_1932 st074806 40.9 µM -1.19578275308018 0.104227109378927 no 3011 0.11589067400663 4351 17251235 SGTC_1502 4534-4282 27.7 µM -1.19690633297536 0.104015815687015 no 3012 0.115671532743604 4230 3278949 SGTC_935 2996-0153 430 µM -1.19758230868854 0.103888845489294 no 3013 0.115539833397815 4283 23738523 SGTC_369 0957-0393 4.5 µM -1.1993683628544 0.103553907466546 no 3014 0.115192371834899 4296 6997992 SGTC_3115 9123671 49.47 µM -1.20085328858501 0.103276037096139 no 3015 0.114904058301052 4407 3286988 SGTC_3338 9144300 39.5675 µM -1.20354922191333 0.102772938346547 no 3016 0.114381927875289 4283 4901274 SGTC_876 0720-0963 56.8 µM -1.20561214593715 0.1023891725059 no 3017 0.113983536881656 4318 765861 SGTC_903 1134-0042 114 µM -1.20629351843868 0.102262645976786 no 3018 0.113852167967038 4295 701009 SGTC_992 3909-8734 162 µM -1.20885416618898 0.101788166800087 no 3019 0.113359438717997 4307 4288319 SGTC_2661 dactinomycin 12.96 µM -1.21355296017288 0.100921668796458 no 3020 0.112459239568297 4260 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_984 1492-0255 2.91 µM -1.21369358388482 0.100895819711576 no 3021 0.112432377683565 4273 1585198 SGTC_3345 9148410 3.559 µM -1.21538017570599 0.100586170850106 no 3022 0.112110562729113 4238 4903596 SGTC_1578 josamycin 24.2 µM -1.21562172259795 0.100541880998798 no 3023 0.112064527644574 4299 5282165 A P450 substrate. SGTC_727 3032-0951 202 µM -1.21642105675446 0.100395417150471 no 3024 0.111912283332586 4342 3652836 SGTC_2569 tetrandrine 100 µM -1.21842171069527 0.100029515347748 no 3025 0.111531879459997 4306 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1899 st063254 59.6 µM -1.2196825347014 0.0997994226218298 no 3026 0.111292622476415 4241 3093813 SGTC_342 k048-0088 23.3 µM -1.22314568798166 0.0991694080951348 no 3027 0.110637337445557 4296 6820570 SGTC_1457 k015-0032 57.3 µM -1.22341858781826 0.0991198862454011 no 3028 0.110585818134836 4290 4302660 SGTC_3263 9137018 49.47 µM -1.22490537623042 0.0988504034040892 no 3029 0.110305437279048 4266 43844957 SGTC_1235 benzylparaben 21.5 µM -1.2336782132109 0.0972712199626595 no 3030 0.108661417728401 4338 7180 SGTC_2678 equilin 100 µM -1.23634417891623 0.0967950111084183 no 3031 0.108165327941617 4300 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2051 5263410 176 µM -1.23713222599139 0.0966545743489467 no 3032 0.108018998779675 4282 227584 SGTC_3272 9137413 49.47 µM -1.2373000172046 0.0966246918481824 no 3033 0.107987860745692 4220 17614870 SGTC_2780 5215298 71.43 µM -1.23983298447951 0.0961744113870338 no 3034 0.107518587669281 4339 2834131 SGTC_290 2043-6722 48.1 µM -1.24039016086281 0.0960755705802104 no 3035 0.107415559238841 4332 773758 YLR208W SEC13 SGTC_1600 coumarin 106 71.1 µM -1.24085378643574 0.0959933822507412 no 3036 0.107329883704683 4381 100336 A hepatotoxic, DNA x-linker. SGTC_3172 9105863 49.47 µM -1.24128033310721 0.0959178126877501 no 3037 0.107251103674757 4398 2348785 SGTC_682 0kpi-0099 17 µM -1.24511780274521 0.0952399102197997 no 3038 0.106544225512643 4336 1714895 YML126C ERG13 SGTC_1466 k213-0079 57.5 µM -1.24524539539516 0.0952174312851234 no 3039 0.106520780316306 4268 3657981 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -1.24664027502713 0.0949719398609601 no 3040 0.106264713568921 4368 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2118 5526350 200 µM -1.24930606831471 0.094504071968442 no 3041 0.105776574630875 4365 743594 SGTC_706 4262-0057 46.9 µM -1.2513642274775 0.0941440128001762 no 3042 0.105400811179333 4321 883298 SGTC_3037 9091026 49.47 µM -1.25272538682267 0.0939064450166798 no 3043 0.105152831826912 4226 25236398 YIL048W NEO1 SGTC_2962 9082311 13.18 µM -1.25278627971898 0.0938958275206492 no 3044 0.105141748084349 4300 16459453 SGTC_328 k915-0120 63.5 µM -1.2587525838616 0.0928598135891824 no 3045 0.104059855875055 4337 6624543 SGTC_3334 9142812 21.919 µM -1.25954526723146 0.0927228072874063 no 3046 0.103916725298799 4343 45283678 SGTC_2148 5546263 113.568 µM -1.26291616253257 0.0921418557693586 no 3047 0.103309655396676 4338 792097 SGTC_1571 st070080 73.4 µM -1.26488825660923 0.0918032301709872 no 3048 0.102955693806056 4347 4315245 SGTC_2068 5226020 147 µM -1.26594552205177 0.0916220685665042 no 3049 0.102766293532425 4349 1810509 SGTC_2086 5274770 176.623 µM -1.26709410221248 0.0914255606103789 no 3050 0.102560822081689 4376 689278 SGTC_2811 7967822 32.47 µM -1.26775255426056 0.0913130485266111 no 3051 0.102443165244294 4379 2232244 SGTC_1152 3909-8331 15.9 µM -1.26824872953701 0.0912283331074976 no 3052 0.102354570024514 4305 16001939 SGTC_2805 7950783 58.44 µM -1.2687513198127 0.0911425818374429 no 3053 0.102264886184778 4349 1178958 YDL195W SEC31 SGTC_2853 9015042 58.44 µM -1.26950769481708 0.0910136428544121 no 3054 0.102130023930491 4268 6457456 SGTC_2552 juarezic acid 87.02 µM -1.27096573134401 0.0907654737610129 no 3055 0.101870420075999 4283 1549512 SGTC_1345 1488-0192 31.4 µM -1.27270673822328 0.0904697991531002 no 3056 0.101561062834077 4389 658348 SGTC_3027 9089541 49.47 µM -1.27307347827089 0.0904076071037428 no 3057 0.101495984600713 4346 9943819 SGTC_2232 chlorophetanol 41.5365 µM -1.27667967176395 0.0897977561520001 no 3058 0.100857680557987 4414 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_1614 st002383 48.6 µM -1.27733278458371 0.0896876346982647 no 3059 0.100742391916421 4379 1947235 SGTC_2085 5307070 144.047 µM -1.28026560009713 0.0891943697511131 no 3060 0.100225870798647 4280 2840351 SGTC_100 0086-0128 49.5915 µM -1.28244151111678 0.0888297136823083 no 3061 0.0998439050880952 4370 93297 SGTC_1579 chlormadinone acetate 49.4 µM -1.2828651697472 0.0887588429678894 no 3062 0.0997696586585376 4399 45114258 A steroidal progestin. SGTC_2460 5552655 174.22 µM -1.28345444265965 0.0886603378915067 no 3063 0.0996664553040569 4368 5401989 SGTC_1747 st037496 66.6 µM -1.28400884408695 0.0885677364234424 no 3064 0.0995694304637484 4314 723305 SGTC_2293 7624732 200 µM -1.28603297993043 0.088230257445272 no 3065 0.0992157759982376 4242 894453 SGTC_1268 0828-0275 2.46 µM -1.29058519235771 0.0874747819878486 no 3066 0.0984237766829791 4419 745337 SGTC_2312 7706453 155.7 µM -1.29297172465048 0.0870806522887331 no 3067 0.0980104193217089 4347 976098 SGTC_2236 dapsone 200 µM -1.29651713986388 0.0864975868879578 no 3068 0.097398689444967 4368 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_2289 7946404 165.07 µM -1.29754774581373 0.0863286461348319 no 3069 0.0972213940699388 4348 1246120 YPR165W RHO1 SGTC_2183 6420625 130.508 µM -1.29982766361501 0.0859557904691995 no 3070 0.0968300209376178 4380 2897619 SGTC_1982 st072467 71.9 µM -1.3048819647137 0.0851335136554714 no 3071 0.0959665216787805 4351 3163533 SGTC_2358 9037157 4 µM -1.30689448897771 0.0848077449851724 no 3072 0.0956242740207804 4371 2388925 SGTC_2280 7785178 200 µM -1.31056929828313 0.0842153140761869 no 3073 0.0950016587383978 4367 2954328 SGTC_3204 9114183 49.47 µM -1.31082873821826 0.0841736063988742 no 3074 0.0949578154906145 4343 17027248 SGTC_657 3534-0529 86.7 µM -1.31477652925794 0.0835408694236594 no 3075 0.0942925088620176 4415 1049549 SGTC_3166 9102297 49.47 µM -1.31646444639491 0.0832714298505691 no 3076 0.0940091020102354 4374 25237072 SGTC_3319 9138450 16.7555 µM -1.31742492651179 0.0831184018494908 no 3077 0.0938481150897232 4302 2029690 SGTC_557 1315-0110 16.2 µM -1.31931633412296 0.0828176727250621 no 3078 0.0935316896564218 4365 6833801 SGTC_3304 9125678 46.087 µM -1.31932268188346 0.0828166648270686 no 3079 0.0935306290280263 4321 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_3306 9127676 59.7925 µM -1.32138502254923 0.0824896945473632 no 3080 0.0931865087253696 4337 41905287 SGTC_3123 9126162 49.47 µM -1.32308279254987 0.0822212546066187 no 3081 0.0929039232116741 4402 25239884 SGTC_404 fumagillin 50 µM -1.32405660856357 0.0820675786049206 no 3082 0.0927421224829385 4394 12015870 A methionine aminopeptidase binder. SGTC_2049 5262831 67.185 µM -1.33260887586868 0.0807272449372862 no 3083 0.0913300954427071 4361 763417 SGTC_1285 0929-0069 65.5 µM -1.33383169488038 0.0805369600860964 no 3084 0.0911295105648471 4426 1206237 SGTC_914 3820-6779 408 µM -1.33400657247803 0.0805097748140244 no 3085 0.0911008512754631 4327 2893481 SGTC_2974 9094440 9.66 µM -1.33622683808865 0.0801652300037305 no 3086 0.0907375707143741 4381 25236134 SGTC_2558 carylophyllene oxide 100 µM -1.3372301072938 0.0800099069719427 no 3087 0.0905737685889849 4508 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.33997903920848 0.0795854917473447 no 3088 0.0901260797949267 4422 5106787 A p450 inhibitor. SGTC_1868 st057644 42.7 µM -1.34146585539976 0.079356649039707 no 3089 0.0898846242135117 4415 688665 SGTC_631 k072-0230 41.5 µM -1.34202088273115 0.07927135002424 no 3090 0.0897946123749609 4392 5773147 SGTC_1484 3473-2379 286 µM -1.34800056555902 0.0783567639493004 no 3091 0.0888291003515285 4525 671917 SGTC_1474 0330-0125 5.35 µM -1.35175915822055 0.0777860001117407 no 3092 0.0882261866904682 4451 X1474 SGTC_2055 5235184 200 µM -1.35453638414564 0.0773662937892352 no 3093 0.0877826568301205 4433 2836034 SGTC_1237 0330-0133 46.1 µM -1.35797267595017 0.0768493701401785 no 3094 0.0872361772676418 4329 X1237 YHR072W ERG7 SGTC_1116 jasmonic acid  1.58368 µM -1.36038688704848 0.076487772114561 no 3095 0.0868537629283149 4444 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_2022 5136654 200 µM -1.36088286708902 0.0764136452669825 no 3096 0.0867753543352911 4420 1713771 SGTC_1961 st076550 68.7 µM -1.36342145099856 0.0760350959976566 no 3097 0.0863748621984663 4428 1579337 SGTC_1128 3448-9350 235 µM -1.36450278036815 0.0758742842955112 no 3098 0.0862046898661382 4417 619386 SGTC_1665 st014639 11.4 µM -1.37072276735921 0.0749542943812394 no 3099 0.0852306973553625 4499 981133 YIL048W NEO1 SGTC_1013 4112-3890 241 µM -1.37092494481242 0.0749245340010431 no 3100 0.0851991771670577 4376 705171 SGTC_3296 9122258 64.045 µM -1.37253054827542 0.0746885102280097 no 3101 0.0849491678937316 4384 4730474 SGTC_1001 4048-4355 44.4 µM -1.37774339743879 0.0739261318579351 no 3102 0.0841412637009454 4409 21824233 SGTC_2803 7707263 71.43 µM -1.37904277593417 0.0737370269992134 no 3103 0.0839407827713375 4391 2199229 SGTC_2825 7998094 58.44 µM -1.38025282067363 0.0735612560258184 no 3104 0.0837544078947534 4387 2987815 SGTC_1754 st042065 16.137 µM -1.38046810572152 0.0735300173397163 no 3105 0.0837212816149698 4184 1126236 YIL048W NEO1 SGTC_258 haloperidol 50.781 µM -1.38647147985627 0.0726629843442565 no 3106 0.0828014915520948 4420 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3311 9131146 2.8755 µM -1.38850660742406 0.0723708462907321 no 3107 0.0824914170846718 4370 4900406 YPR165W RHO1 SGTC_3248 9135562 49.47 µM -1.39219833749804 0.0718432046730933 no 3108 0.0819311730417588 4425 17650701 SGTC_2330 7979373 200 µM -1.39457420066452 0.0715051972513671 no 3109 0.0815721397460957 4358 1863007 SGTC_1198 1612-1005 86.7 µM -1.39587406072045 0.0713207869695382 no 3110 0.0813762115522111 4501 6998509 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -1.39709470804259 0.0711479471313989 no 3111 0.0811925464877858 4404 16623 A steroid. SGTC_890 0929-0006 47.2 µM -1.39801207442347 0.0710182627474627 no 3112 0.081054720670416 4430 1378169 SGTC_86 0417-1630 471.922 µM -1.40562470112052 0.0699490907258033 no 3113 0.0799177985949504 4415 3634867 SGTC_2842 9000675 19.48 µM -1.41083595718474 0.0692243554443907 no 3114 0.0791464947082103 4448 2989072 SGTC_530 4358-1714 28 µM -1.41170312435078 0.0691043209804019 no 3115 0.0790186965145857 4425 1564641 SGTC_1836 st055642 81 µM -1.41335134155483 0.0688766147312656 no 3116 0.0787762225146456 4436 8571 SGTC_2630 antimycin a 100 µM -1.41400443977821 0.0687865473892266 no 3117 0.078680299452718 4386 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2654 protoveratrine a 100 µM -1.42601379136698 0.0671465048270223 no 3118 0.0769321805868538 4471 5702278 A heart drug and vasodilator. SGTC_2021 4019055 173 µM -1.42728650507888 0.0669744853654815 no 3119 0.0767486643964354 4237 44827708 YER133W GLC7 SGTC_1622 st003707 19.4 µM -1.42954492226298 0.0666700779815868 no 3120 0.0764238365144206 4460 10140899 SGTC_1080 nisoldipine 24.4 µM -1.43096427515648 0.0664793149701522 no 3121 0.0762202270469533 4461 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_14 0354-0009 295 µM -1.43246575235155 0.0662779745717428 no 3122 0.0760052863151036 4548 1713507 SGTC_2037 5169046 200 µM -1.43582640499271 0.0658290399032209 no 3123 0.0755258721116399 4506 5718022 SGTC_967 1306-0166 352 µM -1.4401502901717 0.0652549025257356 no 3124 0.0749124417923046 4465 4437607 SGTC_2835 9006588 71.43 µM -1.44182683997188 0.0650333337185232 no 3125 0.074675614573461 4443 2345538 SGTC_1637 st007924 17.4 µM -1.4428446042324 0.0648991135296738 no 3126 0.0745321254920053 4363 683336 SGTC_3273 9137859 49.47 µM -1.44662981182916 0.064401816417933 no 3127 0.0740003160000682 4543 2377234 SGTC_3031 9088762 49.47 µM -1.44827097490021 0.0641871242620177 no 3128 0.0737706408939502 4439 205253 SGTC_1002 4049-0206 172 µM -1.44830522132914 0.0641826501771136 no 3129 0.0737658540344791 4422 4662749 SGTC_1740 st038286 13.222 µM -1.45232686920775 0.0636589304040184 no 3130 0.0732053699132375 4481 716786 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -1.4597181102837 0.0627050824018434 no 3131 0.0721837812468858 4475 6708561 SGTC_2040 5100729 123 µM -1.46256333679572 0.0623408858732573 no 3132 0.0717934507908196 4499 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1367 1812-0510 76.9 µM -1.46535963988498 0.0619845610667565 no 3133 0.0714114114009709 4530 1142582 YDR527W RBA50 SGTC_2364 9055074 200 µM -1.46925369886182 0.061491002493185 no 3134 0.0708819950920896 4461 6470630 SGTC_1038 k292-0204 154 µM -1.47416604058038 0.0608727647522481 no 3135 0.0702184454269103 4416 4454212 SGTC_3245 9134821 49.47 µM -1.47586014969043 0.0606606850650449 no 3136 0.0699907196721854 4497 17014901 SGTC_912 3474-0017 2.18 µM -1.47695462641262 0.0605239788845695 no 3137 0.0698439001948623 4486 3360550 SGTC_905 2-aminofluorene 215 µM -1.47939142663955 0.0602204749072752 no 3138 0.0695178650809108 4487 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1695 st026914 34.495 µM -1.4794908058445 0.0602081225375476 no 3139 0.0695045934154648 4471 3289191 SGTC_1591 genipin 88.4 µM -1.48004321810153 0.0601394964327443 no 3140 0.0694308566972472 4501 442424 A DNA cross-linking agent. SGTC_372 0155-0182 15.9 µM -1.48404014790531 0.0596447813701583 no 3141 0.0688991349694452 4362 771486 SGTC_948 3448-0295 75.3 µM -1.48463581773764 0.0595713268956256 no 3142 0.0688201609917501 4468 678569 SGTC_1241 0364-0022 50.8 µM -1.48806150929633 0.0591502662932634 no 3143 0.06836733653913 4486 4563895 SGTC_684 1140-0066 328 µM -1.48958388868654 0.0589638974553631 no 3144 0.0681668404285491 4504 6813534 SGTC_221 trifluoperazine 10.304 µM -1.48970359177972 0.0589492630276184 no 3145 0.0681510948958894 4466 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_194 1486-1323 56.904 µM -1.49802834078679 0.0579384844893791 no 3146 0.0670629436552663 4575 5178754 SGTC_552 k242-0005 476 µM -1.49989513564464 0.0577137018114561 no 3147 0.0668207841162504 4535 4088318 SGTC_964 1287-0107 19.4 µM -1.50007526281184 0.0576920488408 no 3148 0.0667974539606521 4479 51516812 YPR165W RHO1 SGTC_3013 9080133 71.4286 µM -1.50679896243846 0.0568883575042096 no 3149 0.0659310978071565 4546 17050193 SGTC_185 k048-0037 25.491 µM -1.5087875271728 0.0566523591962002 no 3150 0.0656765446048459 4546 6827589 SGTC_1094 duloxetine 25.4 µM -1.51309970369258 0.0561432499935654 no 3151 0.0651271674422392 4513 60834 A selective serotonin reuptake inhibitor. SGTC_3153 9100258 49.47 µM -1.51329684986329 0.0561200608151977 no 3152 0.0651021362585938 4428 25236848 SGTC_1750 st081859 2.357 µM -1.51546273148571 0.0558657975411454 no 3153 0.064827630725473 4411 5291695 SGTC_3036 9090181 49.47 µM -1.52343163110125 0.0549381059616427 no 3154 0.0638253767102807 4569 25236586 SGTC_2028 5153890 36.43 µM -1.53457567174421 0.0536612492728603 no 3155 0.0624440461758636 4496 2830968 YPR165W RHO1 SGTC_1340 1486-1359 257 µM -1.53482601879981 0.0536328374174996 no 3156 0.0624132849097246 4463 4309068 SGTC_352 k048-0007 5.11 µM -1.535228721871 0.0535871596997482 no 3157 0.0623638277687093 4444 6811911 SGTC_167 3672-0051 66.205 µM -1.53657844299689 0.0534342885368344 no 3158 0.0621982874240707 4427 3237971 SGTC_269 exalamide 29 µM -1.5392722477554 0.0531302179882992 no 3159 0.0618689230765643 4489 3316 A derivative of salicylamide. SGTC_1303 1160-0052 261 µM -1.54207037610675 0.0528158259311872 no 3160 0.0615282463894382 4472 3562476 SGTC_1259 0671-0132 43 µM -1.54542548425418 0.0524408005335793 no 3161 0.06112169003074 4452 X1259 SGTC_1757 st041620 31.8375 µM -1.54742205870003 0.0522186338099507 no 3162 0.0608807527457425 4527 5289815 SGTC_2712 st079126 47.7 µM -1.5483559194275 0.0521149763378324 no 3163 0.0607683139911997 4516 3152970 SGTC_277 nystatin 15.5 µM -1.55934081408352 0.0509078964389229 no 3164 0.0594578682748032 4546 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2855 9016525 58.44 µM -1.56282684529753 0.0505295193970423 no 3165 0.0590466640399333 4464 43811474 SGTC_756 0508-1999 28.3 µM -1.56398333448242 0.0504044890738713 no 3166 0.058910741122731 4539 6753853 SGTC_1103 duloxetine 36.1 µM -1.56793038933602 0.049979620726324 no 3167 0.0584486893551201 4586 60835 A selective serotonin reuptake inhibitor. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.57251483498898 0.049489732683149 no 3168 0.0579156007241888 4472 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_2727 riluzole 51.77 µM -1.57709796437211 0.0490038238879043 no 3169 0.0573864927721891 4578 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2730 imipramine 71.33 µM -1.58281563557314 0.0484029813992918 no 3170 0.0567317459507025 4491 3696 A tricyclic antidepressant. SGTC_7 0192-1582 4.227 µM -1.5863537210245 0.0480341417380799 no 3171 0.0563295461505757 4589 252616 SGTC_2163 5671233 125 µM -1.58781127745912 0.0478828495649577 no 3172 0.0561645102863594 4492 701023 SGTC_124 0136-0217 7.121 µM -1.59145227601573 0.0475065857870705 no 3173 0.0557539137909875 4580 3976905 SGTC_2525 harmine 47.85 µM -1.5919428856082 0.0474560673708368 no 3174 0.0556987691498595 4557 5280953 A monoamine oxidase inhibitor SGTC_253 dyclonine 31.25 µM -1.59904293395054 0.0467297781523186 no 3175 0.0549055315704939 4636 3180 An oral anasthetic. SGTC_1960 st011366 51.8 µM -1.60085299717283 0.0465460540336202 no 3176 0.0547047410884374 4575 3972846 SGTC_2814 7977482 42.97 µM -1.60245156583114 0.0463842794082882 no 3177 0.0545278948691537 4535 6456762 SGTC_1998 st075797 76.8 µM -1.60794061562635 0.0458322226473714 no 3178 0.0539240926807754 4534 24208315 SGTC_704 1310-0270 142 µM -1.61039015811596 0.0455875717997847 no 3179 0.0536563539043926 4526 5718033 SGTC_1516 st013856 110 µM -1.61176786806416 0.0454504334625405 no 3180 0.0535062313872476 4567 5281404 A mutagen and neurotoxin. SGTC_2170 morpholine 200 µM -1.61746002881175 0.0448873446438543 no 3181 0.0528895085363674 4583 121171 Reacts with secondary amines. SGTC_18 0111-0177 500 nM -1.6191645709656 0.0447198223005599 no 3182 0.0527059293449988 4623 721752 SGTC_1522 st012842 45.6 µM -1.62685699924258 0.0439700639874025 no 3183 0.0518837362509936 4403 3491067 YOR116C RPO31 SGTC_3140 9094243 49.47 µM -1.63090545950372 0.0435795631012921 no 3184 0.051455134798695 4517 19291112 SGTC_3353 9151644 39.2805 µM -1.63191930545111 0.0434822104280707 no 3185 0.0513482432663318 4568 4909158 SGTC_1848 st056003 16.4 µM -1.63264540346414 0.0434125961576237 no 3186 0.0512717981025182 4564 146492 SGTC_1449 4112-4002 201 µM -1.6386376312857 0.0428415236362116 no 3187 0.0506443751165087 4593 2059539 SGTC_2726 cimetidine 79.27 µM -1.64421293889672 0.0423156516094544 no 3188 0.0500661125981536 4569 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_60 0986-0278 202 µM -1.64575507248824 0.0421711207142982 no 3189 0.049907097742133 4512 3110598 SGTC_1346 1488-2224 62.4 µM -1.64873190605164 0.0418932576727792 no 3190 0.0496012852953808 4582 3722427 SGTC_3043 9092303 49.47 µM -1.64918237501556 0.0418513395062092 no 3191 0.04955513880833 4567 25236084 SGTC_3006 9075424 71.4286 µM -1.65318913631694 0.0414799849863597 no 3192 0.0491461883744135 4537 7465181 SGTC_1088 bifonazole 369 nM -1.65968079243834 0.0408839967785733 no 3193 0.0484893427038297 4578 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2593 nobiletin 86.24 µM -1.6607320772726 0.0407881368696345 no 3194 0.048383634004531 4540 72344 An anti-infammatory. SGTC_1374 2889-5571 141 µM -1.66162319331309 0.0407070246042453 no 3195 0.0482941749873114 4572 2853281 SGTC_2057 5236571 38.335 µM -1.66366560819229 0.040521611172733 no 3196 0.0480896363848329 4507 54684039 YBR257W POP4 SGTC_13 0199-0087 65 µM -1.67372451409993 0.0396184278973195 no 3197 0.047092376834223 4675 4589825 SGTC_1455 4262-0120 131 µM -1.67665660084208 0.0393582610649128 no 3198 0.0468048258850336 4605 1529587 SGTC_2422 chlorphenesin carbamate 384.24 µM -1.67671366305431 0.0393532117038008 no 3199 0.0467992437737758 4529 2724 A muscle relaxant with antifungal properties. SGTC_2062 5245942 200 µM -1.67825292036945 0.0392172035800981 no 3200 0.0466488673165184 4611 1376160 SGTC_338 4055-0136 114 µM -1.68342732424402 0.0387627976493983 no 3201 0.0461461986879826 4564 2900563 SGTC_3206 9114350 49.47 µM -1.68625530041221 0.0385162686282535 no 3202 0.0458733183011985 4449 17087243 SGTC_2617 dihydrotanshinone i 20.83 µM -1.68746568513343 0.0384111444787565 no 3203 0.0457569213947682 4524 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3308 9128332 17.569 µM -1.69047328922706 0.038150940890055 no 3204 0.0454687220934291 4549 17332805 YDL196W YDL196W SGTC_1926 methyl fluorone black 53.6 µM -1.69129617712181 0.0380799995610346 no 3205 0.0453901249068345 4222 72721 Reacts with homocysteine. SGTC_791 1348-1292 225 µM -1.69382016104668 0.0378630773267788 no 3206 0.0451497309081121 4560 5437054 SGTC_2090 5301565 104.445 µM -1.69619926843064 0.0376595306580462 no 3207 0.0449240744852779 4600 2056344 SGTC_3344 9148862 3.898 µM -1.69953474271028 0.0373756661580131 no 3208 0.0446092370848993 4618 4905352 SGTC_2409 alverine citrate 63.97 µM -1.70110157574376 0.0372429259379518 no 3209 0.0444619575433833 4593 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1172 0370-0043 85 µM -1.70153975425636 0.0372058729776123 no 3210 0.0444208397124633 4613 376585 SGTC_2302 7771753 200 µM -1.7054890942732 0.036873268950977 no 3211 0.0440516222625606 4565 2203047 SGTC_1612 st002233 45.4 µM -1.70890634376999 0.0365874418460522 no 3212 0.0437341496235741 4610 1035021 SGTC_1863 st057641 20.1 µM -1.70945528851329 0.0365416961874863 no 3213 0.0436833235365689 4646 3921635 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.71019638252296 0.0364800122432461 no 3214 0.0436147822146684 4629 91467 include heat shock SGTC_15 0266-0086 27.098 µM -1.71121233506461 0.0363955893165869 no 3215 0.0435209612097369 4658 1712902 YIL048W NEO1 SGTC_2461 5755302 26.15 µM -1.71739925854948 0.0358849181944081 no 3216 0.0429531235287475 4589 2788904 SGTC_1190 1486-1332 13 µM -1.72525124807649 0.0352452798359065 no 3217 0.0422411018083086 4598 4150046 SGTC_1281 0884-0031 11.8 µM -1.73016435740062 0.0348498267312483 no 3218 0.0418004572230714 4611 1548255 SGTC_2597 laccaic acid a 100 µM -1.73258279492967 0.0346565101965118 no 3219 0.0415849247285149 4564 5491415 A textile dye. SGTC_1096 rimcazole 32.2 µM -1.73267150000104 0.0346494363809999 no 3220 0.0415770364327401 4574 18528119 A dopamine reuptake inhibitor. SGTC_481 bay k-8644 50 µM -1.75436039744183 0.0329551036059636 no 3221 0.0396843863516997 4577 2303 A calcium channel antagonist. SGTC_958 1222-0007 33 µM -1.75708706821755 0.032747011889105 no 3222 0.0394514847982644 4644 7312461 SGTC_636 0kpi-0074 126 µM -1.75878798308153 0.0326177524887973 no 3223 0.0393067633154229 4629 616434 SGTC_1954 st077032 68.9 µM -1.76498927259927 0.0321500502853156 no 3224 0.0387827843159484 4554 698907 SGTC_592 k241-0073 46.5 µM -1.77540652474719 0.0313768482368611 no 3225 0.0379153937241097 4649 4230158 SGTC_1255 0566-0045 221 µM -1.77676981902437 0.0312768074116793 no 3226 0.0378030597496636 4620 2788469 SGTC_2001 4023502 57.655 µM -1.7884515893788 0.0304303487047305 no 3227 0.0368515897050005 4600 108941 YCR052W RSC6 SGTC_1407 3909-7909 12.3 µM -1.79031668594426 0.0302969774595776 no 3228 0.036701507661934 4645 4411780 SGTC_2192 5915882 198.485 µM -1.79172593503074 0.0301965250340306 no 3229 0.0365884390001138 4638 2876149 SGTC_2387 9077560 195.08 µM -1.80092320723116 0.0295476955394813 no 3230 0.0358574922938114 4614 5303272 SGTC_1850 st056238 17 µM -1.80650809374721 0.0291593822050086 no 3231 0.0354195055199242 4637 5393177 SGTC_3044 9093193 49.47 µM -1.81042278140089 0.0288897315444655 no 3232 0.0351151245460132 4620 25236277 SGTC_1444 4112-3581 28 µM -1.81471031394434 0.0285967801984841 no 3233 0.0347842196025743 4682 2877249 SGTC_1428 4049-0204 61.7 µM -1.81721372892994 0.0284268764770868 no 3234 0.0345921968038912 4671 X1428 SGTC_38 0929-0051 58.268 µM -1.82504343828095 0.0279008967544024 no 3235 0.0339972372698022 4581 1379719 SGTC_459 nigericin 15.3 µM -1.82844078980839 0.0276752066185946 no 3236 0.0337417121657016 4648 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2261 9010538 184.68 µM -1.8330106600905 0.027374026279029 no 3237 0.0334004929022942 4610 6457250 SGTC_602 3130-1533 38.1 µM -1.83378732697168 0.0273231122798854 no 3238 0.0333427848265 4657 720941 SGTC_693 4161-2696 114 µM -1.8364482245797 0.0271492769740659 no 3239 0.0331456964319729 4657 805759 SGTC_730 1436-0052 41.2 µM -1.83899870975687 0.026983521977145 no 3240 0.0329576879223344 4655 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_3163 9099914 49.47 µM -1.84308855774294 0.0267194881190602 no 3241 0.0326580408422129 4711 16268368 SGTC_3228 9131799 49.47 µM -1.84518114490072 0.026585230730493 no 3242 0.0325055961762783 4672 17015818 SGTC_433 pimozide 108 µM -1.84666723327994 0.0264902280474854 no 3243 0.0323976917028444 4566 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2663 amphotericin b 100 µM -1.84915460644427 0.026331850038127 no 3244 0.0322177456348123 4657 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1767 st044992 70.3 µM -1.84925396013996 0.0263255403846268 no 3245 0.0322105751777853 4641 9600693 SGTC_767 0929-0023 86 µM -1.85507335177815 0.0259581671430165 no 3246 0.0317928762945549 4672 1204563 SGTC_2382 9035899 200 µM -1.87003703884238 0.0250331708061652 no 3247 0.0307393372890445 4643 6462679 SGTC_1966 st070145 16.1 µM -1.87511588139417 0.0247255655218974 no 3248 0.0303883915816391 4636 3748532 SGTC_694 1315-0438 43.2 µM -1.88121984512494 0.0243600744036364 no 3249 0.0299710096272409 4684 6793154 SGTC_334 1502-1024 68.5 µM -1.88220673657863 0.0243014097519546 no 3250 0.029903975679564 4649 3296216 SGTC_1307 1187-1599 12.2 µM -1.89541886327784 0.0235273886171831 no 3251 0.0290184657937559 4676 1538471 SGTC_496 calpeptin 138 µM -1.8990209809989 0.0233199956506879 no 3252 0.0287808587189875 4643 73364 A calpain inhibitor. SGTC_2793 7325131 81.82 µM -1.90515209092706 0.0229705337352061 no 3253 0.0283801518942548 4609 4176441 SGTC_3339 9145883 14.936 µM -1.91317257252983 0.0225200498315651 no 3254 0.0278629817596632 4600 2030670 SGTC_1297 1068-0111 14.1 µM -1.92552843736591 0.0218406513566809 no 3255 0.0270816409163631 4670 767057 SGTC_522 1273-0010 11.6 µM -1.92631549744448 0.0217979669594758 no 3256 0.0270324957543489 4666 5705015 SGTC_2952 9073731 13.78 µM -1.92852970202199 0.0216782624238402 no 3257 0.0268946367309826 4636 16457353 SGTC_2274 7947094 46.08 µM -1.93613374305625 0.0212713923735149 no 3258 0.02642566138006 4650 2971028 SGTC_3078 9116413 49.47 µM -1.94053698548511 0.021038753962117 no 3259 0.026157231918579 4638 17177322 SGTC_2788 5282734 71.43 µM -1.94561782940769 0.0207729944780896 no 3260 0.025850331845471 4665 743706 SGTC_2353 9059630 146.67 µM -1.95413247220685 0.0203340000290134 no 3261 0.0253427763671607 4690 4779114 SGTC_3179 9107801 49.47 µM -1.95447391366758 0.0203165613814247 no 3262 0.0253225984813718 4659 4818259 SGTC_2874 9043904 71.43 µM -1.95563268411402 0.020257473282888 no 3263 0.0252542198967067 4602 4463428 SGTC_190 3970-0790 3.722 µM -1.96131960289228 0.0199695934025587 no 3264 0.0249208759763808 4651 2832352 SGTC_3148 9097893 49.47 µM -1.96530393323483 0.0197699750731761 no 3265 0.0246895353174373 4637 17174100 SGTC_3208 9114115 49.47 µM -1.97403906153993 0.0193382585083796 no 3266 0.0241886507706214 4623 650895 SGTC_286 k060-0067 22.9 µM -1.97466051635435 0.0193078519314299 no 3267 0.0241533432435355 4707 5985051 SGTC_2087 5276107 200 µM -1.97768822705575 0.0191602924555176 no 3268 0.0239819446035072 4680 144405 SGTC_1018 4259-0013 28.1 µM -1.99831657122442 0.0181802423856862 no 3269 0.0228411750304046 4702 6801262 SGTC_1443 4112-3303 14 µM -2.00335020446513 0.0179476861345876 no 3270 0.0225698561441537 4719 704433 SGTC_1409 3909-8004 61.9 µM -2.00687353394284 0.0177864200164091 no 3271 0.0223815652792453 4717 2119279 SGTC_1169 aniline yellow 25.8 µM -2.00737663388143 0.0177634938229205 no 3272 0.0223547874364839 4658 6051 A DNA damaging agent. SGTC_925 2064-1272 59.6 µM -2.00780285833621 0.0177440905665979 no 3273 0.022332122495239 4661 6815817 SGTC_1930 st074634 34.3 µM -2.01749119354364 0.0173078954788104 no 3274 0.0218221395637192 4624 684253 YOR116C RPO31 SGTC_1365 1672-3266 55.4 µM -2.02617281742021 0.0169248388175129 no 3275 0.0213735390768834 4695 6415873 SGTC_3154 9100113 49.47 µM -2.02907741444251 0.0167983090741587 no 3276 0.0212252029693017 4661 25237525 SGTC_427 1354-0053 47.3 µM -2.03856561948853 0.0163906080303345 no 3277 0.0207466997291351 4692 6813657 SGTC_165 k038-0023 64.381 µM -2.03968201535782 0.0163431991083593 no 3278 0.0206910036662006 4656 46368543 SGTC_2484 5809818 12.04 µM -2.041705183619 0.0162575823563258 no 3279 0.0205903921394837 4659 2870548 SGTC_754 3474-0146 171 µM -2.04533347630088 0.0161050018356079 no 3280 0.020410996245124 4696 24762078 SGTC_2131 toluylene red 5.2905 µM -2.07326286615901 0.0149710452810495 no 3281 0.019073911280183 4653 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_1280 0880-0253 10.1 µM -2.08019476001424 0.0147004760295546 no 3282 0.0187538363400431 4708 6836607 SGTC_1027 k015-0025 8.67 µM -2.08199004150024 0.0146310913454521 no 3283 0.0186716896765195 4679 3598955 SGTC_799 1310-0557 151 µM -2.08566750741012 0.0144898426960724 no 3284 0.0185043758328642 4704 5354492 SGTC_3059 1327-0034 3 µM -2.12288965731368 0.0131250086770672 no 3285 0.01688154967365 4589 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2203 7227154 166.4 µM -2.12379347661861 0.013093299020578 no 3286 0.0168437083646089 4732 896304 SGTC_2441 5730946 39.09 µM -2.12914786856822 0.0129067999570927 no 3287 0.0166210142065761 4714 1774275 SGTC_189 3970-0742 2.116 µM -2.13207998585105 0.0128056480394256 no 3288 0.0165001358231517 4711 2891807 SGTC_2467 5474540 200 µM -2.15359214112611 0.0120842778989668 no 3289 0.015636085562396 4708 5413519 SGTC_2694 st077685 81.9 µM -2.17119505046362 0.0115204691371338 no 3290 0.0149582156740213 4644 2838096 SGTC_146 3448-8650 53.125 µM -2.17790558611169 0.0113116292569414 no 3291 0.0147065332741665 4686 2891488 YIL048W NEO1 SGTC_3161 9100388 49.47 µM -2.19040543985306 0.0109313796756222 no 3292 0.0142474229293932 4765 25236368 SGTC_2658 polymyxin b sulfate 77.05 µM -2.19193440299153 0.0108856403506304 no 3293 0.0141921217562668 4745 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_1534 6-azauridine 81.6 µM -2.19820226863004 0.0106998720837571 no 3294 0.0139673475468195 4739 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_805 3852-0218 479 µM -2.20311794727541 0.0105561177213678 no 3295 0.0137932182723657 4720 6615355 SGTC_1576 erythromycin ethylsuccinate 23.2 µM -2.21350563539957 0.0102578643947042 no 3296 0.0134314025739559 4717 3256 An antibiotic and ribosome inhibitor. SGTC_1225 1216-0074 20.6 µM -2.21431093628596 0.0102350524329428 no 3297 0.0134036984133952 4723 4241466 SGTC_3210 9128157 49.47 µM -2.2166208596541 0.0101698639518236 no 3298 0.0133245054544896 4657 17590849 SGTC_1419 3993-2473 62.6 µM -2.22880552858278 0.00983196022090451 no 3299 0.0129134234717005 4767 704026 SGTC_2424 5537928 59.2 µM -2.23232690659791 0.00973615038014035 no 3300 0.0127966824059724 4727 5382802 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -2.23247288905759 0.00973219615093032 no 3301 0.0127918625536278 4725 6710655 SGTC_3288 9119690 36.221 µM -2.23277945484324 0.00972389676541342 no 3302 0.0127817458888918 4721 17595618 YKL019W RAM2 SGTC_3145 9085516 49.47 µM -2.27009894984801 0.00875865969258459 no 3303 0.0116007900215087 4705 25236195 SGTC_1629 st005085 44.9 µM -2.28689582454345 0.00835236067721455 no 3304 0.0111009522013374 4703 24207091 SGTC_1062 mesoridazine 14.2 µM -2.29982017892056 0.00805109350131927 no 3305 0.0107292048736658 4775 4078 A neuroleptic. SGTC_2132 5317594 122.667 µM -2.3030243967585 0.00797789712196498 no 3306 0.0106387352335051 4699 794577 SGTC_1663 st014140 55.4 µM -2.30459733189476 0.00794217996323698 no 3307 0.010594567773098 4775 4207120 SGTC_928 2764-0428 58.7 µM -2.30643403939773 0.00790065126846416 no 3308 0.0105431959089665 4749 662578 SGTC_1201 1889-3372 45.9 µM -2.31800021237754 0.00764349685962956 no 3309 0.0102246547580306 4688 5392199 SGTC_794 k038-0031 316 µM -2.32030424987709 0.00759315979478542 no 3310 0.0101622121915948 4728 6624242 SGTC_1205 4161-2785 76 µM -2.32573559951998 0.00747565283156802 no 3311 0.0100163300537832 4722 3498106 SGTC_3253 9135987 49.47 µM -2.34714048262256 0.00702801221178939 no 3312 0.0094590602090521 4745 4182430 SGTC_1615 st002656 86.5 µM -2.36991868881797 0.00657779372915 no 3313 0.00889599880598722 4754 1584458 SGTC_3016 9080866 49.47 µM -2.37101778515802 0.00655672969905081 no 3314 0.0088695887332589 4746 17066299 SGTC_2134 5324836 1.464 µM -2.37599448291913 0.00646209671668831 no 3315 0.00875086224683696 4734 699272 SGTC_2060 5238662 140 µM -2.38447706372959 0.00630358121885397 no 3316 0.00855170706891643 4734 790130 SGTC_2088 5278280 127.392 µM -2.38791956370499 0.00624023897895578 no 3317 0.00847202490170495 4766 791502 SGTC_2370 9071495 200 µM -2.39456498302734 0.00611955517362358 no 3318 0.00832004726001305 4759 21791103 SGTC_2363 9053361 176 µM -2.40820312580341 0.00587833856386588 no 3319 0.00801562934400542 4735 6469797 YMR079W SEC14 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -2.40909626597774 0.00586283999895231 no 3320 0.00799603955451113 4752 688667 SGTC_1625 st003711 30.1 µM -2.41925023119906 0.00568917129158375 no 3321 0.00777626867612796 4733 24207034 YER133W GLC7 SGTC_1069 diphenylcyclopropenone 8.49 µM -2.42627687205832 0.00557167970789145 no 3322 0.00762731372591077 4766 65057 A dermal irritant. YDR527W RBA50 SGTC_438 sphingosine 6.67 µM -2.45025797327168 0.00518675877400292 no 3323 0.00713769484499421 4729 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1020 4335-0961 93.3 µM -2.48918342907849 0.00461217071056102 no 3324 0.00640184439677974 4735 669075 SGTC_516 3992-2719 87.3 µM -2.49463906830202 0.00453635092242753 no 3325 0.00630426541061797 4697 5350887 YDR037W KRS1 SGTC_2626 ethyl orsellinate 100 µM -2.51907193312246 0.0042102722953321 no 3326 0.00588323078684958 4711 75653 A natural product. SGTC_440 fluspirilene 35.1 µM -2.53321686682251 0.00403122757399517 no 3327 0.00565105022321122 4749 3396 An atypical antipsychotic. SGTC_1242 0402-0103 60.1 µM -2.54023177153308 0.00394498796269581 no 3328 0.0055389515063693 4720 432868 SGTC_274 sirtinol 40.1 µM -2.54024351033679 0.0039448450443427 no 3329 0.00553876558701129 4765 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1298 1079-1278 263 µM -2.55537564720014 0.00376442375189356 no 3330 0.0053036627404471 4756 2840950 SGTC_22 0964-0034 14.468 µM -2.6006576475736 0.00326788830994638 no 3331 0.00465226285028235 4769 138402 SGTC_606 k015-0008 38.6 µM -2.61106254633528 0.0031624690528344 no 3332 0.00451306919408954 4782 1970475 SGTC_436 n,n-dimethylsphingosine 3.3 µM -2.62420169559777 0.00303372448625348 no 3333 0.00434261678260661 4762 5282309 SGTC_160 3453-0671 289.699 µM -2.65906616900958 0.0027146762589013 no 3334 0.00391787860407921 4745 5322268 SGTC_1381 2324-0066 62.1 µM -2.67484375012811 0.00258051360823869 no 3335 0.00373820430123875 4783 10885928 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -2.69310252128174 0.00243275210180331 no 3336 0.00353952487600547 4733 5355888 SGTC_504 lovastatin 124 µM -2.70078967627099 0.00237286580257469 no 3337 0.00345875340552651 4753 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1682 st012968 530 nM -2.70276923846526 0.00235766175782933 no 3338 0.00343822340282763 4758 24207270 SGTC_2171 5739187 198.077 µM -2.71571334568605 0.00226039903766914 no 3339 0.0033066575562952 4766 2262761 SGTC_3159 9100096 49.47 µM -2.71648132874537 0.00225474425315092 no 3340 0.00329899583304659 4746 25236875 SGTC_789 1309-1135 70.6 µM -2.73411217360171 0.00212839989922973 no 3341 0.00312743657856913 4771 3092424 SGTC_3184 9108758 49.47 µM -2.73954915615925 0.00209075384219708 no 3342 0.00307617569664448 4799 902885 SGTC_2725 haloperidol 53.21 µM -2.76237885235699 0.00193918479240818 no 3343 0.00286909262106056 4764 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_525 k781-2675 26.7 µM -2.84950887053918 0.00144808548924952 no 3344 0.00218933923639755 4760 3651118 YDL195W SEC31 SGTC_1408 3909-7976 48.8 µM -2.86130087578347 0.00139115488671988 no 3345 0.00210953221599714 4796 24152374 SGTC_2601 securinine 100 µM -3.00179881737567 0.000853407169301786 yes 3346 0.00134194742183099 4777 442872 A GABA receptor antagonist. SGTC_3236 9132701 49.47 µM -3.01114577809224 0.000825526343193058 yes 3347 0.00130131934383786 4790 24282524 SGTC_1681 tripelennamine 100 µM -3.20195160071724 0.000411013468613692 yes 3348 0.000682499651030284 4775 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_3158 9100007 49.47 µM -3.25087745181405 0.000341670423200948 yes 3349 0.000575247186896832 4793 19297233 SGTC_833 3852-0053 558 µM -3.32278977739604 0.000259259203738704 yes 3350 0.00044561025571275 4798 3123681 SGTC_2428 5615643 7.78 µM -3.53438174394619 0.000111613840710757 yes 3351 0.000204365144019694 4802 2253075 SGTC_424 splitomicin 100 mM -3.53915670003425 0.000109453214196304 yes 3352 0.000200703749130756 4799 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_785 1270-0111 65.3 µM -3.62070323559903 7.81044429477844e-05 yes 3353 0.000146901679271031 4792 6741994 SGTC_46 0329-0187a 2.197 µM -3.66911173184175 6.37197551702729e-05 yes 3354 0.000121697346295822 4760 46494817 SGTC_1675 st018485 24.5 µM -3.89832441104098 2.35213663054889e-05 yes 3355 4.84302987508691e-05 4804 3323024 SGTC_370 0180-0345 38.7 µM -5.84691379114677 5.39093741740687e-10 yes 3356 2.50388431611902e-09 4728 3989527