SGTCid condition conc unit PYC2|YBR218C.score PYC2|YBR218C.strain.pval PYC2|YBR218C.strain.significant PYC2|YBR218C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_213 1246-0773 967 nM 6.08532725727921 3.14856729646072e-09 yes 1 5.81268030213302e-10 5 6251622
SGTC_2951 9072950 58.06 µM 5.74778290410498 2.05738536733905e-08 yes 2 4.52106152882646e-09 7 16488155
SGTC_1942 st076330 65.2 µM 5.56246008839137 5.52298881536789e-08 yes 3 1.32998939819411e-08 6 24208414
SGTC_1679 SEC14.276 6.7 µM 5.4849183142404 8.27341973546315e-08 yes 4 2.06830258675591e-08 31 1005053 YMR079W SEC14
SGTC_2790 5423970 71.43 µM 5.39881700294442 1.28782359754859e-07 yes 5 3.35408771131289e-08 29 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_2639 lactacystin 53 µM 5.30560225430777 2.06389659187683e-07 yes 6 5.61507962819263e-08 10 3870 A proteasome inhibitor.
SGTC_2101 5377231 179.231 µM 5.156154609038 4.32629320861834e-07 yes 7 1.26036393868062e-07 2 2844213
SGTC_2558 carylophyllene oxide 100 µM 5.01457097761825 8.56487666823139e-07 yes 8 2.65759647216993e-07 2 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_3281 9140613 49.47 µM 4.98206023324891 9.99408814425611e-07 yes 9 3.14554222113957e-07 8 16013766
SGTC_1964 st076914 61 µM 4.82021472966925 2.12506002932756e-06 yes 10 7.17018914001632e-07 6 24208661
SGTC_2663 amphotericin b 100 µM 4.78315515450963 2.5175723684253e-06 yes 11 8.62824103079006e-07 6 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2160 5660466 132.927 µM 4.46780214813344 1.01427204609449e-05 yes 12 3.95136726198301e-06 7 2859134
SGTC_3135 9127742 49.47 µM 4.44767827384662 1.10531691095421e-05 yes 13 4.34017050807318e-06 13 3643468
SGTC_3 0833-0587 95.581 µM 4.26035428602577 2.41887955848062e-05 yes 14 1.02051556212352e-05 16 5382644
SGTC_3130 9127414 49.47 µM 4.14762056205302 3.8184928354443e-05 yes 15 1.67974284904076e-05 17 1494646
SGTC_3131 9127911 49.47 µM 4.03844105159238 5.87942581983984e-05 yes 16 2.69038055895636e-05 28 45595681
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 4.00631480641679 6.66243274336859e-05 yes 17 3.08367195100718e-05 80 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2085 5307070 144.047 µM 3.9661456931198 7.77994400053749e-05 yes 18 3.65221117162199e-05 28 2840351
SGTC_2634 4'-methoxyflavone 100 µM 3.94820037262571 8.3342249549545e-05 yes 19 3.9370443864628e-05 33 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_577 r071-0003 38.6 µM 3.94687752716248 8.37652085296796e-05 yes 20 3.95885160815165e-05 54 4568517 YMR134W ERG29
SGTC_2654 protoveratrine a 100 µM 3.94373858104664 8.47769314900845e-05 yes 21 4.01105524700356e-05 6 5702278 A heart drug and vasodilator.
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 3.85992711051139 0.000116445374485686 yes 22 5.67104258608049e-05 18 6708784 An antioxidant flavonoid
SGTC_2543 pimpinellin 60.67 µM 3.8077390656452 0.000141455696824189 yes 23 7.01215689407673e-05 15 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2783 7738165 71.43 µM 3.7666606042046 0.000164592898578705 yes 24 8.27228346571405e-05 35 17201110
SGTC_1843 st055809 45.5 µM 3.60209094586389 0.000297602415573595 yes 25 0.000157833940698294 24 16413835
SGTC_3112 9123419 49.47 µM 3.53173918647219 0.00038063158242312 yes 26 0.000206418158414758 26 17015854
SGTC_2106 5357045 167.29 µM 3.51785397831993 0.000399373113783997 yes 27 0.000217525842793825 28 668842
SGTC_1795 st049545 62.3 µM 3.50967916010042 0.000410803936328149 yes 28 0.000224323846991287 20 5291882
SGTC_1562 morin hydrate 59.1 µM 3.3935316639426 0.000609639352623097 yes 29 0.000344987906865927 32 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2506 ethyl hematommate 54.16 µM 3.31592012905292 0.000788557349857953 yes 30 0.00045670965190224 35 3940691 An allergen.
SGTC_2945 9067681 61.76 µM 3.28259419579787 0.000879298232562728 yes 31 0.000514283076108191 29 16456930
SGTC_1158 4092-0494 91.8 µM 3.26771278733796 0.000922838924009921 yes 32 0.000542101651494732 36 1148199
SGTC_2326 6164455 177.58 µM 3.24830705436011 0.000982593149518302 yes 33 0.000580469576158434 49 2888790
SGTC_169 k015-0017 16.025 µM 3.23983072957049 0.00100979141651287 no 34 0.000598003381085079 36 1840002
SGTC_2466 5983409 37.09 µM 3.21176158025587 0.00110486471930198 no 35 0.000659619047046898 45 2879657
SGTC_2969 9091408 28.7 µM 3.2097390182504 0.00111202262770488 no 36 0.000664277691974118 63 4286311
SGTC_1721 st082152 9.2685 µM 3.17433028651616 0.00124441980872059 no 37 0.000750913442210621 49 5296051
SGTC_1937 st074714 47.2 µM 3.16905238811771 0.00126534550320502 no 38 0.000764684130267434 69 17250970
SGTC_1950 st077106 7.18 µM 3.12830231688021 0.00143806693134439 no 39 0.000879096184535536 69 13831864
SGTC_2896 9052656 71.43 µM 3.07995674768571 0.00167075339389317 no 40 0.0010351532899538 195 6469436
SGTC_958 1222-0007 33 µM 3.05674129672895 0.00179425081275824 no 41 0.00111878651628729 69 7312461
SGTC_575 k072-0246 11.9 µM 3.0550746264126 0.00180342861237336 no 42 0.00112502264000123 65 6796779
SGTC_489 paxilline 115 µM 3.04476733422121 0.00186114230106301 no 43 0.00116430187968798 54 105008 A toxic potassium channel blocker.
SGTC_3028 9087778 49.47 µM 3.02394199297883 0.00198290226005449 no 44 0.00124752136434121 43 17217395
SGTC_2268 7933382 153.85 µM 3.00611830308012 0.00209280887492359 no 45 0.0013230301413964 76 935025 YOR257W CDC31
SGTC_2727 riluzole 51.77 µM 2.97824874787772 0.00227577147786189 no 46 0.00144950301745881 43 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_525 k781-2675 26.7 µM 2.97729218070235 0.00228230096645641 no 47 0.00145403361715747 95 3651118 YDL195W SEC31
SGTC_1649 st011737 51.3 µM 2.97143529773638 0.00232265116340466 no 48 0.0014820566193441 49 1761035
SGTC_3248 9135562 49.47 µM 2.96299482212866 0.00238193729476203 no 49 0.00152330846953016 36 17650701
SGTC_2557 derrustone 83.84 µM 2.95715655491843 0.00242374318431144 no 50 0.00155245214053156 92 629853 An antioxidant.
SGTC_576 1073-0113 22.7 µM 2.93065915473931 0.0026219488968115 no 51 0.00169121839622384 152 5439563
SGTC_2828 7998861 71.43 µM 2.89601269592135 0.00290317034631122 no 52 0.00188968554768474 51 2988188
SGTC_2108 5365811 200 µM 2.87697639625408 0.0030690041507307 no 53 0.00200752813513241 66 780283
SGTC_1237 0330-0133 46.1 µM 2.87539801544206 0.00308312993806601 no 54 0.00201759239577563 70 X1237 YHR072W ERG7
SGTC_44 0929-0055 61.211 µM 2.84990800815585 0.00331950594407228 no 55 0.002186593776281 87 1379590
SGTC_440 fluspirilene 35.1 µM 2.83739471301097 0.00344140482039794 no 56 0.0022741672498246 76 3396 An atypical antipsychotic.
SGTC_3166 9102297 49.47 µM 2.82847563884688 0.00353072957962576 no 57 0.00233851302799853 87 25237072
SGTC_2667 digitoxin 100 µM 2.82275385496486 0.00358912406749336 no 58 0.00238065556236531 28 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_843 0310-0051 143 µM 2.80516494565804 0.00377409718757637 no 59 0.00251454183398945 63 2065037
SGTC_784 4579-0127 173 µM 2.8008138161603 0.00382115473318784 no 60 0.00254869594248093 84 1948547
SGTC_2365 9042475 200 µM 2.80056794105451 0.00382382950909859 no 61 0.00255063839331487 101 6464479
SGTC_1043 0916-0009 19.3 µM 2.79677375310491 0.00386531825016749 no 62 0.00258078318006889 91 3101130
SGTC_828 2074-0507 139 µM 2.79035428601721 0.00393643329937714 no 63 0.00263251968216435 82 X828
SGTC_1665 st014639 11.4 µM 2.78973516147588 0.00394335356802685 no 64 0.00263755860957946 92 981133 YIL048W NEO1
SGTC_1675 st018485 24.5 µM 2.78456581471764 0.0040015606427627 no 65 0.00267997210874648 99 3323024
SGTC_2539 epi(13)torulosol 80 µM 2.78079022098704 0.00404455891503239 no 66 0.00271133827880625 82 6708597
SGTC_680 0417-1641 114 µM 2.77926846173174 0.00406200606757398 no 67 0.00272407390013093 64 2835990
SGTC_3068 9116768 49.47 µM 2.73909069505943 0.00454770069298122 no 68 0.00308046875826195 94 41904888
SGTC_1385 3091-4834 14.1 µM 2.72040496315707 0.00479076008384138 no 69 0.00326010056318485 71 4072814
SGTC_2377 9073351 62.6 µM 2.68527558871301 0.00527925759631547 no 70 0.00362350116164969 94 7337946 YHR072W ERG7
SGTC_3188 9110789 49.47 µM 2.68315417874656 0.00531012810580127 no 71 0.00364656795542493 97 849217
SGTC_2370 9071495 200 µM 2.65979939005789 0.00566074650991302 no 72 0.00390936029827828 118 21791103
SGTC_1710 st031758 61.5 µM 2.65726826403608 0.00569995365927378 no 73 0.00393883645183335 66 5394341
SGTC_411 enrofloxacin 100 µM 2.63322265893741 0.00608461109926366 no 74 0.00422894399254906 66 71188 A bacterial gyrase inhibitor.
SGTC_1612 st002233 45.4 µM 2.61831571687798 0.00633446978375276 no 75 0.00441825030876684 93 1035021
SGTC_551 k048-0028 34.9 µM 2.60930244146714 0.00648991130387937 no 76 0.00453635082232613 104 6836383
SGTC_3301 9125354 19.7965 µM 2.59803786421691 0.0066889157033874 no 77 0.00468790773463057 71 41905162
SGTC_2867 9039098 71.43 µM 2.59291009957996 0.00678127759172475 no 78 0.00475838218627575 130 6463460
SGTC_2732 terfenadine 20 µM 2.55726623511688 0.00745501889302985 no 79 0.00527492195985585 57 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2495 cafestol 54.53 µM 2.54876605302179 0.0076241468431771 no 80 0.0054052396484565 120 16667697 An anti-infammatory.
SGTC_2286 7945697 125 µM 2.53723853296871 0.00785890291308219 no 81 0.00558653979172711 160 1245733
SGTC_3041 9091929 49.47 µM 2.51697920713373 0.00828691755500691 no 82 0.0059182907157424 102 25236887
SGTC_872 0588-0139 234 µM 2.50945785567199 0.00845095474276373 no 83 0.00604583216716154 141 2047100
SGTC_2846 9008642 19.48 µM 2.49239704602952 0.00883364512526857 no 84 0.00634420547526887 97 2992898
SGTC_2806 7952793 58.44 µM 2.4867179452336 0.00896435981429785 no 85 0.00644637856962553 121 2972490
SGTC_3098 9119039 49.47 µM 2.47148997038362 0.00932325660390679 no 86 0.0067275662746433 131 17161528
SGTC_1765 st044815 90.4 µM 2.46181790143986 0.00955768386879929 no 87 0.00691174156803192 120 645695
SGTC_3079 9117512 49.47 µM 2.45121542410109 0.00982056700211312 no 88 0.00711873580539473 40 7185044
SGTC_61 0978-8327 98.565 µM 2.43662324981449 0.0101926887846423 no 89 0.00741255816868512 130 6150059 YHR072W ERG7
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 2.43385077200136 0.0102647649498218 no 90 0.00746957634575414 113 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_3338 9144300 39.5675 µM 2.41839199297964 0.0106748505537516 no 91 0.00779463641007584 127 4901274
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 2.41330115746569 0.0108129864495266 no 92 0.00790437560506758 139 3256 An antibiotic and ribosome inhibitor.
SGTC_877 0771-0151 33.1 µM 2.41062262103125 0.0108862892557579 no 93 0.00796265849966337 116 6166523
SGTC_3231 9132313 49.47 µM 2.41016324448281 0.0108989042431236 no 94 0.00797269205194213 96 4905967
SGTC_1444 4112-3581 28 µM 2.40922077066514 0.01092482544363 no 95 0.00799331206265831 111 2877249
SGTC_2555 cholic acid 100 µM 2.39993478892884 0.0111831026229918 no 96 0.00819899641018853 100 6708657 Influences liver metabolism.
SGTC_2327 6189656 200 µM 2.39858798801453 0.0112209995026541 no 97 0.00822921089948443 115 5349088
SGTC_581 0958-0271 211 µM 2.39678935506249 0.0112717843080277 no 98 0.00826971441642434 202 4591145
SGTC_785 1270-0111 65.3 µM 2.3925734604915 0.0113916046232043 no 99 0.00836533924827178 155 6741994
SGTC_840 0245-0196 390 µM 2.38517836342383 0.0116044557241334 no 100 0.00853542124109702 130 3827528
SGTC_2943 9068529 45.32 µM 2.37063108551577 0.0120332613722542 no 101 0.00887887285422138 152 3270634
SGTC_2862 9027634 71.43 µM 2.35943908264416 0.0123724523271344 no 102 0.00915129278497313 135 5012562
SGTC_1671 st016596 74.5 µM 2.35045079638418 0.012650822400483 no 103 0.00937534327236136 135 2829167
SGTC_1364 1653-0028 37.6 µM 2.34234695807479 0.0129064311067315 no 104 0.00958144565404562 143 5718652
SGTC_2567 aureobasidin a 60 nM 2.34209241195119 0.0129145317483972 no 105 0.00958798310288892 248 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_33 0986-0033 35.816 µM 2.31552981127306 0.0137843861580298 no 106 0.0102919775151743 119 2848082
SGTC_1897 st060201 15 µM 2.31467557206403 0.0138131793749829 no 107 0.0103153468017723 135 611878
SGTC_977 1348-1378 135 µM 2.30532592094187 0.0141317271890511 no 108 0.0105741634383845 157 X977
SGTC_1229 0139-0193 12.2 µM 2.3007816551197 0.0142888254629935 no 109 0.0107019879414241 141 3090752
SGTC_2611 pyromycin 23.93 µM 2.29629299223534 0.0144454758495692 no 110 0.0108295672610972 158 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_670 4204-0025 119 µM 2.28309199666639 0.0149147751082157 no 111 0.0112124749507476 168 719039
SGTC_771 0250-0039 27.3 µM 2.27446019379367 0.015228676292938 no 112 0.0114691659200012 130 3005115
SGTC_2517 totarol 10 µM 2.27332812648097 0.0152702626549398 no 113 0.0115032068997056 143 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3138 9097216 49.47 µM 2.26825968515638 0.015457649291584 no 114 0.0116566917785072 140 25237486
SGTC_282 k297-0036 65.7 µM 2.25683528123977 0.0158872754814133 no 115 0.0120091846330013 101 5061378
SGTC_16 erodoxin 22.806 µM 2.2565265444539 0.0158990265201005 no 116 0.0120188374153498 234 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2610 ononetin 44.17 µM 2.2537392140311 0.0160054547450995 no 117 0.0121062894280736 222 259632
SGTC_606 k015-0008 38.6 µM 2.25148400778742 0.0160920113216992 no 118 0.0121774493313642 169 1970475
SGTC_2524 avocatin b 10.57 µM 2.25044959924775 0.0161318467301122 no 119 0.0122102097473193 124 6710748
SGTC_2015 5119600 184 µM 2.24457187798271 0.0163598074263074 no 120 0.0123978148928295 166 2828786
SGTC_2426 5582046 32.21 µM 2.24011801678484 0.0165343773491643 no 121 0.0125416310860826 180 2251934
SGTC_3272 9137413 49.47 µM 2.23686316837007 0.016662957905 no 122 0.0126476422230495 148 17614870
SGTC_2515 chrysin 20.77 µM 2.21971838148372 0.0173544617972718 no 123 0.013218945143028 132 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_355 1311-2252 105 µM 2.20682983799529 0.0178903031726443 no 124 0.0136629748207252 194 5338538
SGTC_380 3970-0968 6 µM 2.1971935372666 0.0183000944742437 no 125 0.0140033134853042 154 2891601
SGTC_2088 5278280 127.392 µM 2.19115279218486 0.0185610386048553 no 126 0.0142203687439297 210 791502
SGTC_2104 5389443 200 µM 2.19070477809512 0.0185805171853919 no 127 0.0142365815545705 194 2244536
SGTC_397 arbidol 50 µM 2.18763710263104 0.0187143604864113 no 128 0.0143480234821954 176 131410 A RNA synthesis inhibitor.
SGTC_697 0508-1955 564 µM 2.18431973206803 0.0188600206152773 no 129 0.014469380908518 203 6243113
SGTC_3117 9124945 49.47 µM 2.16958974513911 0.0195184933602198 no 130 0.0150189694681957 126 17592065
SGTC_2858 9025781 8.96 µM 2.15944077601875 0.0199834577396725 no 131 0.015407993663498 315 4894980 YPL153C RAD53
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 2.1365537769521 0.0210665865058394 no 132 0.0163171512946027 131 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1854 st056233 32.9 µM 2.13261867651514 0.0212577325643101 no 133 0.0164780099827664 172 5393174
SGTC_2893 9048488 25.97 µM 2.12205134968751 0.0217783083370674 no 134 0.0169167130880729 167 6467338
SGTC_55 0767-0285 6.563 µM 2.10882466646971 0.0224450276179377 no 135 0.017479859324076 230 3116166
SGTC_7 0192-1582 4.227 µM 2.09614995039728 0.0230999935564092 no 136 0.0180344455786407 282 252616
SGTC_559 1550-0661 158 µM 2.09007073776263 0.0234198035600284 no 137 0.0183057229160058 170 5830875
SGTC_2659 sanguinarine 24.21 µM 2.08895598144795 0.0234788500843871 no 138 0.0183558428949164 175 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2937 9044753 11.33 µM 2.0837053365311 0.0237586536495166 no 139 0.0185934892577472 249 6465530 YGL099W LSG1
SGTC_572 0960-0087 17.7 µM 2.08310131488681 0.0237910206552622 no 140 0.0186209947813007 259 6796365
SGTC_2888 9058547 12.99 µM 2.08044110347526 0.0239340117930329 no 141 0.0187425462328593 133 16476514
SGTC_1460 k062-0059 9.15 µM 2.07869100163445 0.0240284762507557 no 142 0.018822880291024 202 1373085
SGTC_2964 9083345 53.42 µM 2.07742688008441 0.0240969038665411 no 143 0.0188810887064941 190 17741579
SGTC_2655 perillic acid 100 µM 2.07681233415354 0.0241302286792675 no 144 0.0189094416898919 117 5702197 An apoptosis inducer.
SGTC_1163 k060-0048 49.9 µM 2.07508519253623 0.0242240932710293 no 145 0.0189893199175572 225 6809982
SGTC_3223 9129970 49.47 µM 2.06147418116982 0.0249745916781793 no 146 0.0196289120882748 207 17248386
SGTC_1940 st075990 51.1 µM 2.05826514701836 0.0251543470450152 no 147 0.0197823439583362 237 1084979
SGTC_67 0335-0847 266 µM 2.05721455001524 0.0252134317639958 no 148 0.0198327962832579 361 4552207 YOR254C SEC63
SGTC_1341 1486-1360 280 µM 2.04374228123937 0.0259814639552037 no 149 0.0204895069401072 209 3976547
SGTC_1368 1852-0141 284 µM 2.04011793252233 0.0261913914717928 no 150 0.0206692905225441 216 2838987
SGTC_3204 9114183 49.47 µM 2.03342558592159 0.026582749326034 no 151 0.0210047722853567 217 17027248
SGTC_895 0964-0006 13.7 µM 2.01620956540782 0.0276120150955477 no 152 0.0218890333097152 200 6738897
SGTC_807 1315-0151 48 µM 2.01127401298303 0.0279131430208447 no 153 0.0221482609139789 250 4011080
SGTC_1948 st076329 66.6 µM 2.00468269274741 0.0283195540136397 no 154 0.022498489964058 210 24208413
SGTC_1650 st011916 45.8 µM 1.99615713265842 0.0288525201574714 no 155 0.0229584109216916 175 242528
SGTC_3058 9093861 49.47 µM 1.99427348896278 0.0289713919066189 no 156 0.0230610874100215 230 17217477
SGTC_1955 wogonin 32.4 µM 1.98549924759675 0.0295304870884218 no 157 0.0235444768737988 192 5281703 A flavanone.
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 1.98206668521984 0.0297516338064803 no 158 0.0237358888002817 106 1241132 A phosphatase inhibitor.
SGTC_1408 3909-7976 48.8 µM 1.98063906376554 0.0298440136503812 no 159 0.0238158824400289 253 24152374
SGTC_3055 9094636 49.47 µM 1.97992759375565 0.0298901408715125 no 160 0.0238558326434235 200 25236176
SGTC_2784 7567673 72.73 µM 1.96895515675552 0.0306090439809875 no 161 0.0244791204083688 273 3471247
SGTC_38 0929-0051 58.268 µM 1.96468399726301 0.0308927311660099 no 162 0.0247254116232484 253 1379719
SGTC_1581 himbacine 57.9 µM 1.94883040203045 0.0319648080213062 no 163 0.0256578408984562 275 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1441 4106-0040 13 µM 1.94218382849562 0.0324233242117091 no 164 0.0260574250432556 219 2904180
SGTC_1139 k015-0024 46.9 µM 1.93669241288587 0.0328062330037719 no 165 0.0263914768791274 186 2766652
SGTC_1039 k821-0043 94 µM 1.93336234591933 0.0330402443723797 no 166 0.0265957882071265 239 15992768
SGTC_2657 nystatin 74.44 µM 1.93083936836452 0.0332184540921164 no 167 0.026751460075318 235 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2995 9067767 71.4286 µM 1.9291964047949 0.0333349294146767 no 168 0.0268532421695202 208 11673567
SGTC_1734 st037168 69.4 µM 1.92739026068671 0.0334633610364919 no 169 0.0269655062292672 252 708907
SGTC_1498 4478-3555 97.6 µM 1.92547314504143 0.0336001290488902 no 170 0.0270850962496574 156 3437919
SGTC_399 oxolinic acid 75 µM 1.92199324458523 0.0338495623333029 no 171 0.027303303891487 195 4628 A DNA gyrase inhibitor.
SGTC_2423 st077119 87.2 µM 1.91900299364026 0.0340651133829098 no 172 0.027491977493106 243 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2724 maprotiline 69.64 µM 1.91615113968811 0.0342717384089143 no 173 0.0276729302602144 208 4011 A tricyclic antidepressant.
SGTC_1261 0712-0010 12.7 µM 1.91437637636531 0.0344008443394087 no 174 0.0277860409097822 281 2840123
SGTC_2777 climbazole 1.536 µM 1.91181953006589 0.0345875456064842 no 175 0.0279496729362477 283 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_609 0986-0026 86.3 µM 1.89577888102771 0.0357779107544894 no 176 0.0289946448001968 289 2848610
SGTC_2983 9022671 12.99 µM 1.89136174557145 0.0361115348091469 no 177 0.0292880357388344 229 6405161
SGTC_970 1315-0089 19.5 µM 1.8851852097728 0.03658231299447 no 178 0.0297024184726611 227 6811083 YLR033W RSC58
SGTC_1907 st060210 83.7 µM 1.880099646683 0.0369736953749845 no 179 0.0300472493168729 291 688793
SGTC_957 1187-1561 14.1 µM 1.8681917629244 0.0379035208229315 no 180 0.0308676732593335 293 1538454
SGTC_2051 5263410 176 µM 1.86767295279674 0.0379444619075296 no 181 0.0309038354393411 259 227584
SGTC_377 3970-0964 33.1 µM 1.86143940710443 0.0384391991568574 no 182 0.0313410749762247 364 16481235
SGTC_791 1348-1292 225 µM 1.85872320762399 0.0386564140633265 no 183 0.0315331910845995 345 5437054
SGTC_2711 st079103 59.1 µM 1.85570936845878 0.0388986006479635 no 184 0.0317474973714362 212 54693780
SGTC_1289 0976-0073 69.1 µM 1.85471093169044 0.0389791051563221 no 185 0.0318187584319191 253 3391136
SGTC_1175 0741-0056 27.6 µM 1.85246771623902 0.0391604717036723 no 186 0.0319793446321482 295 765927
SGTC_2460 5552655 174.22 µM 1.84894769614057 0.0394464534544647 no 187 0.0322326827904364 277 5401989
SGTC_2112 5488546 200 µM 1.84623049229007 0.0396683709269565 no 188 0.0324293726385716 285 600757
SGTC_2376 9072922 81.32 µM 1.84466261859771 0.0397968823635042 no 189 0.0325433159279502 298 17087968
SGTC_105 0111-0055 734.78 µM 1.84379279426694 0.0398683237292474 no 190 0.0326066716291833 203 5179370
SGTC_3097 9117246 49.47 µM 1.84336709602081 0.0399033256187248 no 191 0.0326377154173931 279 16423892
SGTC_1695 st026914 34.495 µM 1.84050120848206 0.0401396160483191 no 192 0.0328473435036619 271 3289191
SGTC_2387 9077560 195.08 µM 1.83872477357793 0.0402866516845769 no 193 0.0329778388510499 273 5303272
SGTC_2884 9058502 51.95 µM 1.83680311590633 0.0404461996552845 no 194 0.0331194828892934 289 6471554
SGTC_2312 7706453 155.7 µM 1.83325964065759 0.0407417460201926 no 195 0.0333819841432345 288 976098
SGTC_2612 dictamnine 15.46 µM 1.83289439554681 0.0407723089496334 no 196 0.0334091386890948 289 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_2728 chlorpromazine 9.18 µM 1.83218716662 0.0408315412384221 no 197 0.0334617700981867 157 2726 A thorazine and dopamine antagonist.
SGTC_1203 3992-3522 103 µM 1.8317641017415 0.0408670073984935 no 198 0.0334932868644512 298 5322312
SGTC_1876 myriocin 605 nM 1.83014250842121 0.0410031795320279 no 199 0.033614315986867 243 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1762 st045503 25.4615 µM 1.83006231789233 0.0410099230117682 no 200 0.0336203104094068 278 4645554
SGTC_3284 9108171 64.8615 µM 1.82931378325657 0.0410729130935962 no 201 0.033676307504539 229 8687505
SGTC_1664 st014217 9.02 µM 1.82681983079154 0.0412833485533149 no 202 0.0338634316010671 271 3982782
SGTC_2177 5811945 192 µM 1.82584567542342 0.0413657831220793 no 203 0.0339367555076664 267 5343475
SGTC_307 1501-1223 22.3 µM 1.82563808518771 0.0413833669687319 no 204 0.0339523975276276 247 2830329
SGTC_1735 st034310 56.75 µM 1.82386504183514 0.0415337988382116 no 205 0.0340862389113151 281 871153
SGTC_799 1310-0557 151 µM 1.81756450213418 0.0420719490944505 no 206 0.0345653606567458 300 5354492
SGTC_3349 9149703 23.001 µM 1.81647950435275 0.042165189533997 no 207 0.0346484245675151 251 4910494
SGTC_1635 st007035 42.4 µM 1.80877165865487 0.0428323946577257 no 208 0.035243242513879 525 3716403
SGTC_1061 3448-9325 110 µM 1.80857339320047 0.0428496687946753 no 209 0.0352586525675016 227 723482
SGTC_1744 st037937 38.9 µM 1.80694605303859 0.042991665787987 no 210 0.0353853454952914 266 1016152
SGTC_2285 7945142 200 µM 1.80661576396734 0.0430205322183164 no 211 0.0354111049335932 287 2970608
SGTC_973 1325-0077 65.9 µM 1.80500814299141 0.0431612579023082 no 212 0.0355367038987834 287 2835149
SGTC_2278 7948257 134.34 µM 1.80490383040055 0.0431704019028494 no 213 0.0355448661538201 268 1247028
SGTC_968 1309-0633 340 µM 1.80279722679005 0.043355401039756 no 214 0.0357100329394055 264 3761976
SGTC_1772 st048439 82.2 µM 1.80189153775028 0.0434351339578136 no 215 0.0357812359379135 325 2927068 YDL195W SEC31
SGTC_1222 0366-0074 1.18 µM 1.80103199333334 0.0435109139446124 no 216 0.0358489187179537 278 286520
SGTC_1445 4239-0156 97.7 µM 1.78981032979462 0.0445100733194301 no 217 0.036742203998754 326 4008346
SGTC_3080 9117754 49.47 µM 1.78238005733872 0.0451817661538285 no 218 0.0373436376906374 311 9550191
SGTC_2767 sibutramine 71.45 µM 1.7821985549165 0.0451982753679855 no 219 0.0373584291934796 288 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2020 4017018 200 µM 1.78029916320086 0.045371332778337 no 220 0.0375135070062307 286 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1923 st058458 19.1 µM 1.77834934733299 0.0455495383959568 no 221 0.0376732481458348 349 3534982
SGTC_589 1227-0070 34.1 µM 1.77581795256219 0.0457817372238439 no 222 0.0378814638571932 283 2841384
SGTC_1509 1326-1131 80 µM 1.77474836727437 0.0458801332131581 no 223 0.0379697225939744 258 768313
SGTC_233 rapamycin 362 pM 1.77365180879775 0.0459811869311419 no 224 0.0380603811660344 278 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1410 3909-8106 77.9 µM 1.77314805204174 0.0460276707115714 no 225 0.0381020886822476 234 1039210
SGTC_1079 idarubicin 2.36 µM 1.77283416473249 0.0460566535138929 no 226 0.0381280951892009 247 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1004 4084-0029 199 µM 1.76666910475627 0.0466288820057279 no 227 0.0386418301864277 298 716894 YLR208W SEC13
SGTC_2189 6047310 154.431 µM 1.76574051021867 0.0467155645484743 no 228 0.0387196965465204 284 711535
SGTC_816 0325-0417 81.3 µM 1.76132471934044 0.04712954091344 no 229 0.0390917292529075 260 68101
SGTC_1676 st018489 23.4 µM 1.76089783662148 0.0471697161893141 no 230 0.0391278480826426 332 3696235
SGTC_298 1391-0729 10 µM 1.75347853801181 0.0478723644591975 no 231 0.0397599501606782 264 3237558
SGTC_3282 9108498 15.4605 µM 1.75129332813685 0.0480809057037041 no 232 0.0399476981920337 317 16459645
SGTC_421 streptovitacin 30 mM 1.74932390070751 0.0482694764392737 no 233 0.0401175234156655 342 91467 include heat shock
SGTC_2431 5490079 200 µM 1.74520359222168 0.0486659055030224 no 234 0.040474718088019 302 5722345
SGTC_2199 6590217 200 µM 1.74195450390086 0.048980343284628 no 235 0.040758202782791 225 703109
SGTC_2739 tacrine 100.86 µM 1.73759752512559 0.0494045449534802 no 236 0.0411408781154607 273 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_161 4065-0411 162.148 µM 1.73481390576931 0.0496770940642358 no 237 0.0413868861658647 395 1906281 YLR208W SEC13
SGTC_686 1319-0111 510 µM 1.732105959531 0.049943383790071 no 238 0.0416273491561698 318 4562600
SGTC_632 0781-2353 4.65 µM 1.73069811086525 0.0500822756659374 no 239 0.0417528111879601 343 6811515 YHR007C ERG11
SGTC_2946 9065502 71.43 µM 1.72737487897818 0.0504113519819868 no 240 0.042050179604648 182 16489101
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 1.72435738670994 0.0507116433713395 no 241 0.042321672685421 287 279621
SGTC_310 1273-0058 1.06 µM 1.71754023955578 0.0513953093347175 no 242 0.0429402543465902 606 2734232
SGTC_552 k242-0005 476 µM 1.71743073336042 0.0514063508283962 no 243 0.0429502501405047 272 4088318
SGTC_175 3793-3120 23.7 µM 1.71103358677845 0.0520546551419636 no 244 0.0435374564054442 304 5322297
SGTC_2775 cyproheptadine 69.59 µM 1.70767753030953 0.0523973553887386 no 245 0.0438480968292351 297 2913 A selective serotonin reuptake inhibitor.
SGTC_2400 5203494 178.7 µM 1.70594034970202 0.0525754480337708 no 246 0.0440095931024047 294 6777674
SGTC_49 0717-0965 32.132 µM 1.70124470677938 0.0530592418702123 no 247 0.0444485230305036 334 5889349 YGL099W LSG1
SGTC_1980 st071811 45.7 µM 1.70037524318914 0.0531492091651541 no 248 0.0445301827376364 305 4974850
SGTC_409 arachidonic acid 100 µM 1.69871310037062 0.0533215351064252 no 249 0.0446866269368279 312 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2954 9074818 52.69 µM 1.69522647396229 0.0536844566306026 no 250 0.0450162332962283 358 16648742
SGTC_2202 7226349 200 µM 1.69427076836091 0.0537842765298262 no 251 0.0451069212932167 256 844334
SGTC_1604 st002052 72.4 µM 1.69124004578598 0.0541017966192687 no 252 0.0453954827515137 335 6254834 YHR062C RPP1
SGTC_528 3492-0019 172 µM 1.69046517348754 0.0541832154497402 no 253 0.0454694978036022 586 2869262
SGTC_2903 5923464 63.88 µM 1.68044034751553 0.0552453271007578 no 254 0.0464358357010238 272 2876576
SGTC_2664 lyso-paf C-16 73.48 µM 1.67920008407377 0.0553778659997068 no 255 0.0465565278033779 349 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1466 k213-0079 57.5 µM 1.67434375175381 0.0558992484989477 no 256 0.0470315302619274 335 3657981
SGTC_2288 7946289 167.31 µM 1.67305982692088 0.0560377376936295 no 257 0.0471577595111321 392 1246052
SGTC_2838 9002687 71.43 µM 1.67043893442737 0.0563212773894832 no 258 0.0474162759201357 319 6457060
SGTC_3001 9076041 71.4286 µM 1.66694032524911 0.056701533383094 no 259 0.0477631357075442 310 16004211
SGTC_1992 st073643 23.3 µM 1.66653714268985 0.056745484046049 no 260 0.0478032383382263 302 3161292
SGTC_102 gallobenzophenone 83.616 µM 1.66095306517043 0.0573569640510431 no 261 0.0483614367106044 372 70837
SGTC_1383 3049-0032 20.7 µM 1.65982596277954 0.0574810130698578 no 262 0.0484747345675801 350 712864
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.65720640893346 0.0577701367170699 no 263 0.048738875631236 378 5379071
SGTC_2617 dihydrotanshinone i 20.83 µM 1.65335728455245 0.0581970426325653 no 264 0.0491290854193516 389 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1268 0828-0275 2.46 µM 1.65299806430181 0.0582370098210945 no 265 0.0491656287601897 337 745337
SGTC_2712 st079126 47.7 µM 1.65249919015352 0.0582925507982321 no 266 0.0492164150447147 318 3152970
SGTC_2011 4012611 177 µM 1.64843280772471 0.0587468250346376 no 267 0.049631944163373 356 2049887
SGTC_1171 0368-0077 21.4 µM 1.64626490863195 0.0589901439812211 no 268 0.0498546154180888 308 3239779
SGTC_1962 st076595 64.5 µM 1.64378848142677 0.0592690579059331 no 269 0.0501099507341863 366 279619
SGTC_2520 obtusaquinone 4.71 µM 1.64377112960244 0.0592710158411702 no 270 0.050111743488378 335 5967872
SGTC_2662 daunorubicin 22.37 µM 1.64036547204625 0.0596562843020681 no 271 0.0504645999850075 308 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_984 1492-0255 2.91 µM 1.63986584271655 0.0597129700649638 no 272 0.0505165321466181 322 1585198
SGTC_97 0535-0701 19.132 µM 1.63969332507806 0.0597325529621215 no 273 0.0505344737532841 321 2832013 YGL099W LSG1
SGTC_728 3030-5151 22.5 µM 1.63949585174744 0.0597549748164104 no 274 0.0505550169495217 310 3125388
SGTC_1534 6-azauridine 81.6 µM 1.63911252954433 0.0597985174632309 no 275 0.0505949130369349 412 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_795 0685-0265 78 µM 1.63826490183499 0.0598948901275155 no 276 0.0506832229777404 367 302754
SGTC_691 1548-0686 185 µM 1.63661845272035 0.0600824339366232 no 277 0.050855108765159 393 46495133
SGTC_1479 0549-0158 134 µM 1.6363998630811 0.0601073675937928 no 278 0.0508779639165761 371 5440202
SGTC_2221 6807166 181.081 µM 1.63464906071519 0.0603073671216391 no 279 0.0510613183372191 243 674925
SGTC_2008 4012253 172 µM 1.63382754662569 0.0604013905549922 no 280 0.0511475332517815 393 603940
SGTC_2837 9008476 45.46 µM 1.63222758954472 0.060584837098806 no 281 0.0513157753846729 390 2992805
SGTC_2518 prenyletin 46.28 µM 1.63004702072209 0.0608355563996237 no 282 0.0515457797736506 249 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_460 trequinsin 123 µM 1.6294368530212 0.0609058578586009 no 283 0.0516102862702346 320 5537 A vasodilator.
SGTC_1731 st035964 63 µM 1.62659433416703 0.0612342007849912 no 284 0.05191164172911 378 6739575
SGTC_1866 st057638 64 µM 1.62064542707502 0.0619258415719335 no 285 0.0525468518992049 333 688802
SGTC_2981 9013952 38.96 µM 1.61949861474722 0.0620598722560169 no 286 0.052670012150451 352 2996344
SGTC_3171 9103192 49.47 µM 1.61542220260532 0.0625381250670369 no 287 0.0531096476627689 294 13018434
SGTC_2505 galangin 7.89 µM 1.6142455209609 0.0626767087510207 no 288 0.0532370908849407 286 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_199 4063-0024 41.6 µM 1.61288342959346 0.0628374278286584 no 289 0.053384917933641 327 306215
SGTC_1816 st051957 91.6 µM 1.6125411027317 0.0628778709126216 no 290 0.0534221215907072 335 674121
SGTC_1233 0325-0408 14.2 µM 1.61232909055013 0.0629029285637985 no 291 0.0534451731112081 361 12874
SGTC_133 0724-0033 378.92 µM 1.61224423735376 0.0629129595152834 no 292 0.0534544011817602 336 280309
SGTC_2407 paclitaxel 400 µM 1.60349826603044 0.0639535675199984 no 293 0.0544123458237729 415 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1976 st070609 63.5 µM 1.60230655477933 0.0640963891996891 no 294 0.0545439184605828 375 682556
SGTC_2726 cimetidine 79.27 µM 1.60049684260821 0.0643137497751831 no 295 0.0547442034040889 287 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1117 retinoic acid 1.10837 µM 1.59794770006859 0.0646208929011667 no 296 0.0550273085232739 400 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_652 0437-0092 114 µM 1.59142581108036 0.0654118937870655 no 297 0.0557568896805751 330 3091274
SGTC_1402 3909-7673 35.9 µM 1.58899633697558 0.0657084626055708 no 298 0.0560306098507821 360 5328014
SGTC_2451 5856223 45.7 µM 1.58535931129283 0.0661543856215663 no 299 0.056442360146749 368 2179896
SGTC_1963 st076565 50.3 µM 1.58044704844142 0.0667603777111761 no 300 0.0570022621211103 375 4914280
SGTC_2335 9018011 154.17 µM 1.57340761593006 0.0676362609285701 no 301 0.0578122323298422 429 6458208
SGTC_3070 9117005 49.47 µM 1.57154298078763 0.0678697495216314 no 302 0.0580282895059849 283 8779016
SGTC_2 0422-0095 29 µM 1.57091075678947 0.0679490574185763 no 303 0.0581016898273196 273 6790840
SGTC_2854 9024559 71.43 µM 1.57017479183875 0.0680414689777394 no 304 0.0581872261996802 395 3163529
SGTC_1773 st048542 73.5835 µM 1.56993222284185 0.0680719484448789 no 305 0.0582154400684009 408 3237138
SGTC_2225 6654152 15.4 µM 1.56843331719249 0.0682605239531136 no 306 0.0583900203800704 292 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2019 4016004 108 µM 1.56331942225328 0.0689069319801459 no 307 0.058988741107585 337 45595336
SGTC_106 0092-0003 11.579 µM 1.56202577397182 0.0690711975577322 no 308 0.0591409586006872 294 1072148
SGTC_2797 7859098 81.82 µM 1.56033824410168 0.0692859310365829 no 309 0.0593399851298241 404 972681
SGTC_1706 st031321 9.9705 µM 1.5593816480619 0.0694078834030059 no 310 0.0594530386331132 371 6103185
SGTC_98 0074-0023 107.663 µM 1.55234669395212 0.070309824249926 no 311 0.0602896454301178 420 3563821
SGTC_2651 TUB2.036 5 µM 1.5520109376339 0.0703530953482808 no 312 0.0603298032660904 609 15992207 YFL037W TUB2
SGTC_3169 9102970 49.47 µM 1.54735633726394 0.0709550755330931 no 313 0.0608886718646183 332 17027839
SGTC_765 1319-0117 244 µM 1.54644060748973 0.0710739714047905 no 314 0.0609990967355195 358 3487746 YGL099W LSG1
SGTC_2992 9074591 71.4286 µM 1.54640057606822 0.0710791724642837 no 315 0.0610039275632567 373 17741321
SGTC_936 3005-4620 401 µM 1.54512606466051 0.0712449154610928 no 316 0.0611578867604553 425 777207
SGTC_1609 st001574 46.4 µM 1.54420130478908 0.0713653608801068 no 317 0.0612697864311075 399 3960012
SGTC_335 4077-0256 27.6 µM 1.54395827566123 0.0713970401468082 no 318 0.0612992204636624 455 3121989
SGTC_385 1494-0393 12.4 µM 1.53787954694292 0.0721929288781555 no 319 0.0620390345337602 403 3090647
SGTC_1241 0364-0022 50.8 µM 1.53652202112554 0.0723715952894134 no 320 0.0622052005715639 426 4563895
SGTC_2691 st077356 60.2 µM 1.53648777106888 0.0723761073786438 no 321 0.0622093973871251 423 2839272
SGTC_1681 tripelennamine 100 µM 1.53242072759235 0.0729134320377644 no 322 0.0627093228807816 349 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2620 irigenin 100 µM 1.53179873146029 0.0729958766807338 no 323 0.0627860546060624 431 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1438 4092-1045 4 µM 1.53014162733085 0.0732158715698509 no 324 0.0629908381694518 399 1351342
SGTC_372 0155-0182 15.9 µM 1.52797966252077 0.0735036532553827 no 325 0.0632587937495734 431 771486
SGTC_2080 5212524 12.4 µM 1.52694395700633 0.0736418233168277 no 326 0.0633874738993323 363 260183
SGTC_1176 0848-0131 83.3 µM 1.51621014317562 0.0750855009207815 no 327 0.0647331120345652 452 6769040
SGTC_1053 3366-3204 134 µM 1.51586567493201 0.0751321861467274 no 328 0.064776660649879 449 3632071 YPR165W RHO1
SGTC_77 0828-0286 12.516 µM 1.51533535616034 0.0752041026590411 no 329 0.0648437494624488 441 745345
SGTC_2792 7535235 81.82 µM 1.51518122701353 0.075225013948381 no 330 0.0648632579277541 394 1281891
SGTC_1784 st039334 36.3 µM 1.51119325641147 0.0757676196984438 no 331 0.0653696100224721 418 3496984
SGTC_3318 9139014 38.6185 µM 1.50155629434508 0.0770911320198354 no 332 0.0666058689391623 391 16643984
SGTC_3228 9131799 49.47 µM 1.49922488554292 0.0774139447962937 no 333 0.0669076506031323 397 17015818
SGTC_2315 7733312 200 µM 1.49867726533568 0.0774899183654417 no 334 0.0669786887003231 381 726316
SGTC_1835 st008666 49.2 µM 1.49652951234584 0.0777884314100055 no 335 0.0672578615726826 353 690455
SGTC_2859 9028643 45.46 µM 1.49640380777922 0.0778059299037521 no 336 0.0672742289420441 376 17151580
SGTC_1651 st011928 86.1 µM 1.49160061282817 0.0784767909188562 no 337 0.0679019387304015 414 720198
SGTC_1917 st066507 28.5 µM 1.49104188105849 0.078555112694774 no 338 0.0679752497893801 487 3156428
SGTC_2885 9057732 51.95 µM 1.48815948963149 0.0789601014312463 no 339 0.0683544189247618 417 6471414
SGTC_3120 9124077 49.47 µM 1.48479103954737 0.0794353853102588 no 340 0.0687995931328484 418 18774327 YGL155W CDC43
SGTC_3234 9132280 49.47 µM 1.47751515668941 0.0804693879293221 no 341 0.0697687992396138 462 17612295
SGTC_2382 9035899 200 µM 1.47702580061381 0.0805392953792547 no 342 0.0698343606876278 438 6462679
SGTC_3255 9139072 49.47 µM 1.47498255026726 0.0808316816796705 no 343 0.070108617416627 421 17646060
SGTC_369 0957-0393 4.5 µM 1.47067064777407 0.0814513380541081 no 344 0.0706901039286933 416 6997992
SGTC_931 2812-0076 566 µM 1.46848985558507 0.0817660970826406 no 345 0.070985604898203 464 3450959
SGTC_1911 st060208 74.3 µM 1.46617595218223 0.0821010699605624 no 346 0.0713001790926904 476 688783
SGTC_2139 5578692 56.4705 µM 1.46485167310389 0.082293244162468 no 347 0.0714806951405569 386 650991 YMR113W FOL3
SGTC_211 3455-0679 143.504 µM 1.45286061414432 0.08404878663148 no 348 0.0731312291665657 470 748649
SGTC_1174 0739-0097 51.1 µM 1.45246194432702 0.0841076328536455 no 349 0.0731866016414367 470 728447
SGTC_212 3807-4682 38.772 µM 1.44830303998065 0.0847233592568752 no 350 0.0737661589295152 591 3125501 YBL034C STU1
SGTC_259 usnic acid 108.925 µM 1.44808361093596 0.0847559393906598 no 351 0.0737968342499449 462 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_855 0428-0020 25 µM 1.44797161766882 0.0847725714191183 no 352 0.0738124942271682 405 6812414
SGTC_107 0358-0022 2.6945 µM 1.44511067543205 0.085198277842771 no 353 0.0742134004324944 312 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_1556 plumbagin 1.48 µM 1.44508200921007 0.0852025514493862 no 354 0.0742174258524518 385 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_516 3992-2719 87.3 µM 1.44490510206 0.0852289286070246 no 355 0.074242271517668 408 5350887 YDR037W KRS1
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 1.43795757310353 0.0862696616338649 no 356 0.0752230462605496 445 7104
SGTC_2325 6158266 200 µM 1.43702583958125 0.0864099541245016 no 357 0.0753553257668617 450 3623240
SGTC_634 1611-4317 11.2 µM 1.43636319525634 0.0865098332124229 no 358 0.0754495101422195 492 2843522
SGTC_885 0865-0106 16.8 µM 1.4352933827259 0.0866712660822661 no 359 0.0756017563177492 472 2793380
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.43468262481134 0.0867635293019441 no 360 0.0756887788317313 468 4213774
SGTC_1206 3978-0017 132 µM 1.43283956935103 0.0870423925790166 no 361 0.0759518451665665 435 3873677
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.42891484641465 0.0876384519887179 no 362 0.0765143548704529 481 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_600 1495-0418 41.6 µM 1.42834613165028 0.0877250764270268 no 363 0.076596127939432 446 5377768
SGTC_2782 7736369 71.43 µM 1.42435579813663 0.0883346657653793 no 364 0.0771717513866 502 2950836 YOL077C BRX1
SGTC_134 0269-0018 6.916 µM 1.42325932984187 0.088502720997093 no 365 0.0773304960754436 526 4378915
SGTC_881 0833-0569 170 µM 1.42177593470679 0.0887304592966947 no 366 0.0775456539595479 478 5418700
SGTC_568 1193-0097 7.48 µM 1.42014385571951 0.0889815282016738 no 367 0.0777829024325966 531 3646150
SGTC_1239 0337-0584 35.4 µM 1.41881155692593 0.0891868725205477 no 368 0.0779769812220715 538 914301 YML130C ERO1
SGTC_2072 5231554 129 µM 1.41707616019197 0.0894548739740373 no 369 0.0782303308673859 463 789545
SGTC_2709 st078560 56 µM 1.41648334071152 0.0895465616205521 no 370 0.0783170191725459 450 17250903
SGTC_104 0074-0074 590.992 µM 1.41259191801643 0.0901501590929439 no 371 0.0788878733791022 314 3943124
SGTC_3102 9121669 49.47 µM 1.41139181741042 0.0903369147865944 no 372 0.0790645571765364 409 41905072
SGTC_315 k915-0449 187 µM 1.40243607455715 0.0917396584394794 no 373 0.0803925336036572 563 20970215 YNL149C PGA2
SGTC_2035 5154463 94.595 µM 1.39692364398109 0.0926110596690658 no 374 0.0812182668315276 508 2769623
SGTC_90 0870-0863 4.608 µM 1.39428146960875 0.0930308969309836 no 375 0.0816163121949464 530 1738164
SGTC_215 1287-0124 461.5 µM 1.39376043202145 0.0931138547745305 no 376 0.0816949801941706 386 5560863
SGTC_3106 9121286 49.47 µM 1.39004040947348 0.0937077333501054 no 377 0.0822583034472745 425 15943471
SGTC_731 3966-0296 387 µM 1.38993540067795 0.0937245378442743 no 378 0.0822742472848018 474 660956
SGTC_488 nitrendipine 139 µM 1.38885386850653 0.0938977442607832 no 379 0.0824385953912885 516 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2646 retinol 96.75 µM 1.38871861390212 0.0939194217742234 no 380 0.0824591658667233 455 445354 A vitamin A analog and teratogen.
SGTC_432 NS 1619 61.3 µM 1.38644322924928 0.0942846559052284 no 381 0.0828058020111708 442 4552 A K+/calcium channel activator.
SGTC_621 3584-0052 32.1 µM 1.38054554334406 0.095236199576674 no 382 0.0837093685622938 509 2273927
SGTC_2198 6589944 200 µM 1.37962878764304 0.0953847434345888 no 383 0.0838504845601444 379 5290268
SGTC_2096 5468907 200 µM 1.3763598001619 0.0959158127674427 no 384 0.0843551336454553 473 759785
SGTC_727 3032-0951 202 µM 1.37536455476503 0.0960779281883526 no 385 0.0845092260535057 454 3652836
SGTC_1426 4048-4480 71.7 µM 1.37474997830694 0.0961781370472698 no 386 0.0846044854425901 515 14224343
SGTC_137 0438-0332 85.389 µM 1.37456979576785 0.0962075310057952 no 387 0.0846324290094912 646 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_402 epigallocatechin gallate 10 µM 1.37214498103061 0.096603744142408 no 388 0.0850091545184016 528 65064 An antioxidant.
SGTC_3099 9120367 49.47 µM 1.36795212046685 0.0972916808047599 no 389 0.0856635318113259 483 24824940
SGTC_913 3487-1245 167 µM 1.36783499495018 0.0973109494529882 no 390 0.0856818655173775 509 4016153
SGTC_590 k048-0076 22.4 µM 1.36768518654546 0.0973355989355956 no 391 0.0857053193708948 491 6832814
SGTC_524 r073-0010 27.8 µM 1.3673097043494 0.0973974009239415 no 392 0.0857641256064633 484 2772106
SGTC_989 1501-0895 10.3 µM 1.36677904134828 0.0974847937700499 no 393 0.0858472870223253 473 2830112
SGTC_3003 9075612 71.4286 µM 1.36359351236752 0.0980106154094122 no 394 0.0863477675468508 494 6501993
SGTC_2014 4013930 200 µM 1.36310545282803 0.098091360567682 no 395 0.0864246392604317 559 64556
SGTC_1763 st044482 94.5 µM 1.35950838766512 0.098687967114835 no 396 0.0869927732117078 516 88505
SGTC_1820 st053765 18.6 µM 1.35914445151271 0.0987484769225597 no 397 0.0870504096951767 483 3690829
SGTC_2697 mebhydrolin 72.4 µM 1.35820399512953 0.0989049675376627 no 398 0.0871994816260322 570 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2388 9080168 200 µM 1.35353625180919 0.0996843590434756 no 399 0.0879421884159669 454 15943073
SGTC_997 3996-0078 137 µM 1.3515642026139 0.100014984854071 no 400 0.0882573842132414 534 735687
SGTC_1019 4262-0212 3.4 µM 1.34353417780833 0.101369535720389 no 401 0.0895495333968651 602 4677213
SGTC_995 3931-2021 34.6 µM 1.34346858003896 0.101380655893865 no 402 0.0895601466676738 495 730143
SGTC_48 0382-0018 55 µM 1.34325815556108 0.101416333175767 no 403 0.0895941982231329 491 762596
SGTC_2172 5754775 163.918 µM 1.33924482203834 0.10209854178968 no 404 0.0902454925807643 482 2263357
SGTC_1511 0906-3109 28.5 µM 1.3390652486096 0.102129144523969 no 405 0.0902747162088051 627 2882180
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 1.33565302202503 0.102711921665168 no 406 0.0908313554985745 506 4330530
SGTC_1446 4239-0190 62 µM 1.33546608889783 0.102743917822851 no 407 0.0908619234691989 565 1340085
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.32936026650142 0.103792998238393 no 408 0.0918645700053765 533 688669
SGTC_287 k060-0039 29.6 µM 1.32281684218665 0.104925867927843 no 409 0.0929481474512875 512 5861974
SGTC_1889 st059080 5.18 µM 1.32170991911706 0.105118392533864 no 410 0.0931323821934079 569 176925 Isolated from Daphnopsis sellowiana.
SGTC_2066 5222451 176 µM 1.32139967744274 0.105172398000747 no 411 0.0931840667753644 597 2281147
SGTC_19 0279-0214 38.434 µM 1.32078479156627 0.105279493877965 no 412 0.0932865660596907 635 3566274 YBR002C RER2
SGTC_422 cantharidin 155 µM 1.31594819132884 0.10612464611943 no 413 0.094095716134105 548 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.314726287524 0.106338936223646 no 414 0.0943009542616313 529 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1594 piperine 70.1 µM 1.31180349922415 0.106852784439796 no 415 0.0947932219849082 546 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_847 0342-0274 5.54 µM 1.31086868077372 0.107017510086108 no 416 0.0949510668465491 545 18097
SGTC_1662 st014054 52 µM 1.3100552445392 0.107160995776153 no 417 0.0950885736985029 492 2838777
SGTC_1330 1469-0054 61.8 µM 1.30691411315563 0.10771637625296 no 418 0.0956209411820456 541 7102664
SGTC_3202 9113761 49.47 µM 1.30678987648466 0.107738384971246 no 419 0.0956420421472211 619 4798415
SGTC_1369 1866-0067 208 µM 1.30663686814182 0.107765495087089 no 420 0.0956680345422686 605 3531355
SGTC_483 fpl-64176 144 µM 1.30637375715376 0.107812124749576 no 421 0.0957127428506345 456 3423
SGTC_2362 9071156 126 µM 1.3050068513727 0.108054607556599 no 422 0.095945257410657 530 653133
SGTC_1590 st077108 57.8 µM 1.3043598613734 0.108169517423759 no 423 0.0960554569797176 522 5489485
SGTC_327 1273-0057 3.96 µM 1.30385399495224 0.108259424030947 no 424 0.0961416842664383 516 3108138
SGTC_1367 1812-0510 76.9 µM 1.30053480009354 0.108850672136257 no 425 0.0967088685022002 533 1142582 YDR527W RBA50
SGTC_2069 5228469 200 µM 1.30011615397547 0.108925410119448 no 426 0.096780580945182 516 2835210
SGTC_210 3551-0445 56.827 µM 1.29620430028325 0.109625549473136 no 427 0.0974525542043065 556 2865180 YOR207C RET1
SGTC_1207 2099-0101 141 µM 1.29371430822913 0.110072885133958 no 428 0.0978820606033646 595 5837381
SGTC_2064 5220758 200 µM 1.29187316772309 0.110404493490208 no 429 0.0982005356852011 604 788518
SGTC_959 1222-0044 107 µM 1.28922825603778 0.110882121980165 no 430 0.0986593722346634 554 6083612
SGTC_2935 9038016 29.96 µM 1.28454266480781 0.111731894915249 no 431 0.0994760726638774 579 6463195
SGTC_821 1114-0266 29.2 µM 1.28315388606442 0.111984654755337 no 432 0.0997190840648375 540 3123235
SGTC_1861 st057647 17.4 µM 1.28270588100392 0.112066279504553 no 433 0.0997975693735617 579 688668
SGTC_1215 3852-0577 11.2 µM 1.28183254833366 0.112225519513585 no 434 0.0999506968672802 618 2884876
SGTC_2344 7990960 76.95 µM 1.2815955487993 0.112268760950596 no 435 0.0999922812297123 518 140813
SGTC_1021 4476-0760 85.3 µM 1.28044155883073 0.112479480802424 no 436 0.100194942909977 559 746768
SGTC_2924 9010168 62.78 µM 1.27964485312588 0.112625124919746 no 437 0.100335033815361 581 2993929
SGTC_1339 1486-1321 22.7 µM 1.275089064214 0.113460546607806 no 438 0.101138859817981 576 3469382
SGTC_3144 9087057 49.47 µM 1.27434705670306 0.113597030282889 no 439 0.101270223251024 557 17249618
SGTC_92 0063-0024 660.874 µM 1.27414946761403 0.113633394230815 no 440 0.101305224954019 627 3594437
SGTC_1416 3966-0321 25.3 µM 1.27178255784253 0.114069641360526 no 441 0.101725193940266 587 582530 YLR208W SEC13
SGTC_1211 1056-0033 32.3 µM 1.27162781219994 0.114098204152793 no 442 0.101752695072667 574 6741922
SGTC_166 k072-0058 166.424 µM 1.2695448546258 0.114483170225273 no 443 0.102123401643665 568 5846229
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.26941669402366 0.114506886647179 no 444 0.102146242592594 513 364106
SGTC_2525 harmine 47.85 µM 1.26732487063485 0.114894477956935 no 445 0.102519575582788 500 5280953 A monoamine oxidase inhibitor
SGTC_2360 9040895 200 µM 1.26700584145447 0.114953672388852 no 446 0.102576600597305 530 4914414
SGTC_2682 pyrogallin 40.03 µM 1.26408265134864 0.115497067259705 no 447 0.103100181396233 625 822798 An ATP competetive kinase inhibitor.
SGTC_546 peri-Naphthalide 147 µM 1.25967265707154 0.116320295317514 no 448 0.103893736522951 574 223824 A penicillin ester.
SGTC_3050 9093513 49.47 µM 1.25501219792737 0.117194793823681 no 449 0.104737165968469 563 25236664
SGTC_2274 7947094 46.08 µM 1.25270990032487 0.1176285163412 no 450 0.105155650818573 587 2971028
SGTC_662 k832-1615 104 µM 1.25051894371032 0.118042317644858 no 451 0.10555501981282 564 5878478
SGTC_531 3788-1495 174 µM 1.24971132552277 0.118195110189108 no 452 0.105702509309437 575 2896655
SGTC_1559 coumarin 343 70.1 µM 1.24707147727038 0.118695516155836 no 453 0.106185645121129 535 108770 A hepatotoxic, DNA x-linker.
SGTC_1740 st038286 13.222 µM 1.24650259557214 0.118803548324626 no 454 0.106289968451056 594 716786
SGTC_2927 9011802 47.9 µM 1.24222735059031 0.119617651455623 no 455 0.107076345573397 570 43912568
SGTC_3113 9123498 49.47 µM 1.24158463407471 0.119740378604623 no 456 0.107194927012992 582 8897275
SGTC_687 k029-0044 34.9 µM 1.24102936414422 0.119846479241747 no 457 0.107297450744377 619 5829338
SGTC_1659 st012954 42.1 µM 1.240770425943 0.119895979649844 no 458 0.107345284645731 566 24207262
SGTC_1570 verbenone 133 µM 1.24022926835987 0.11999947759099 no 459 0.107445302834347 617 29025 A natural terpanoid with antifungal properties.
SGTC_2193 5925765 200 µM 1.23908968783627 0.120217631529163 no 460 0.107656142759488 529 877370
SGTC_631 k072-0230 41.5 µM 1.23855585675552 0.120319920755342 no 461 0.107755012180843 642 5773147
SGTC_3067 9117431 49.47 µM 1.23750728700102 0.120521019300152 no 462 0.10794940535533 536 17150885
SGTC_1440 4100-1550 40 µM 1.23630579847917 0.120751736003806 no 463 0.108172458286517 536 742806
SGTC_121 0557-0495 61.343 µM 1.23530317135425 0.120944504027326 no 464 0.108358846950609 760 3104427
SGTC_2496 diffractaic acid 79.83 µM 1.23446592963016 0.121105640395846 no 465 0.10851466740057 614 94870 An apoptosis inducer which activates caspases.
SGTC_690 glyoxal 20.3 µM 1.23201480977367 0.121578253394104 no 466 0.108971775989793 611 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_370 0180-0345 38.7 µM 1.23142356666151 0.121692447809418 no 467 0.109082243636172 528 3989527
SGTC_1437 4092-1038 11.6 µM 1.23133173126509 0.121710191925734 no 468 0.109099409346613 621 3977136
SGTC_1472 k841-0093 193 µM 1.2308948266761 0.121794634011822 no 469 0.109181101369458 637 X1472
SGTC_493 zm226600 134 µM 1.2212324687279 0.1236726401295 no 470 0.110999007030368 616 5240098 A potassium channel opener. YCR052W RSC6
SGTC_136 0097-0015 404.482 µM 1.21857313563548 0.124193056030817 no 471 0.111503125268719 656 4861337
SGTC_1714 st033236 13.627 µM 1.2184027884216 0.124226444112822 no 472 0.111535472997128 621 2916566
SGTC_127 0180-0333 59.125 µM 1.21704343788688 0.124493102011581 no 473 0.1117938446415 693 771601
SGTC_1405 3909-7894 12 µM 1.21601619031365 0.124694878016208 no 474 0.111989377284815 607 7104060
SGTC_549 1661-1316 519 µM 1.21423320604023 0.125045641221209 no 475 0.11232934182255 625 2857282
SGTC_22 0964-0034 14.468 µM 1.21397067530913 0.12509734655814 no 476 0.11237946120723 640 138402
SGTC_1885 st057546 99.9 µM 1.2137718936678 0.125136506465711 no 477 0.112417420967654 641 702008
SGTC_2259 7964009 200 µM 1.21002279999681 0.125876680149752 no 478 0.113135072093402 568 313134
SGTC_1254 0550-0035 264 µM 1.20492883595664 0.126887252599183 no 479 0.114115387764084 659 15121435
SGTC_72 0744-0168 198.391 µM 1.2031993449414 0.12723164065417 no 480 0.114449594171794 607 677577
SGTC_907 3448-6986 75.5 µM 1.19885639105894 0.128099304232086 no 481 0.115291895530427 676 590582
SGTC_3293 9120939 62.045 µM 1.19829279070979 0.128212204552854 no 482 0.115401526110093 605 934087
SGTC_2026 5148700 152 µM 1.19631501249683 0.12860893936478 no 483 0.115786826244332 612 79838
SGTC_2364 9055074 200 µM 1.1938529217777 0.129104014750257 no 484 0.116267752952444 578 6470630
SGTC_2212 7123476 200 µM 1.19339344178181 0.129196552757761 no 485 0.116357661114417 522 1085715
SGTC_1646 st011709 75.6 µM 1.18920504206612 0.130042204951368 no 486 0.117179495454361 587 5757843
SGTC_2874 9043904 71.43 µM 1.18862108495646 0.13016041149974 no 487 0.11729440346194 523 4463428
SGTC_3221 9128209 49.47 µM 1.18767258967791 0.130352567505914 no 488 0.117481213421349 576 16460723
SGTC_3295 9122362 53.5725 µM 1.18739037657026 0.130409779023764 no 489 0.11753683706981 599 4730473
SGTC_2022 5136654 200 µM 1.18668025260173 0.130553815394388 no 490 0.117676883584429 617 1713771
SGTC_260 nsc-65238 3.989 µM 1.17975882146607 0.131963470199516 no 491 0.11904807579567 612 3246252
SGTC_484 loperamide 105 µM 1.17727965280116 0.132470934860675 no 492 0.119541952716211 526 3955 An opioid-receptor agonist.
SGTC_564 3555-0129 330 µM 1.17572616569443 0.132789604840577 no 493 0.119852159582952 542 563260
SGTC_461 N-acetylfarnesylcysteine 136 µM 1.17434246798787 0.133073889761675 no 494 0.12012893969358 590 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3081 9117243 49.47 µM 1.17416767370224 0.133109831561196 no 495 0.120163935693024 615 45595589
SGTC_790 1575-0012 79.1 µM 1.17395923717019 0.133152699727799 no 496 0.120205676680579 669 378741 YLR208W SEC13
SGTC_740 k014-0057 261 µM 1.17080038748224 0.133803528757635 no 497 0.120839511021151 715 4012779
SGTC_360 0957-0399 1.01 µM 1.16900870724211 0.134173645299017 no 498 0.121200061629746 678 6752301 YPR165W RHO1
SGTC_3189 9110682 49.47 µM 1.15957996557211 0.136132972576929 no 499 0.123109930875038 638 17122418
SGTC_2123 5259487 200 µM 1.1590399275683 0.136245784364881 no 500 0.123219955170515 691 2173474
SGTC_945 3381-0768 11.3 µM 1.15596746290089 0.136888827159149 no 501 0.12384723299263 700 1126236 YIL048W NEO1
SGTC_2389 9091542 195.52 µM 1.15264273233697 0.137587000552556 no 502 0.12452852799826 681 3626624 YOL127W RPL25
SGTC_3051 9093778 49.47 µM 1.15013681835023 0.138114831124969 no 503 0.125043761993193 593 17217378
SGTC_270 tamoxifen 5.46 µM 1.14744743756447 0.138682840349788 no 504 0.12559837253528 732 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_3268 9137683 49.47 µM 1.14681801153561 0.138816007400423 no 505 0.125728421764744 631 1953228
SGTC_905 2-aminofluorene 215 µM 1.14591009142462 0.139008248529568 no 506 0.125916177643085 718 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1166 k206-0078 225 µM 1.14521908938412 0.139154681281117 no 507 0.126059206318043 700 5404595
SGTC_1458 k015-0034 6.33 µM 1.14466863565526 0.139271405028952 no 508 0.126173224297018 630 3598957
SGTC_1684 st024538 14.6195 µM 1.14308525327163 0.139607532721993 no 509 0.126501598182512 677 6732859
SGTC_2217 6934799 96.0675 µM 1.14108041701807 0.140033919433518 no 510 0.126918229868285 652 675606
SGTC_824 1304-0008 100 µM 1.140796032256 0.140094473704485 no 511 0.126977406076264 689 768245
SGTC_1766 st045414 44.774 µM 1.14014513343181 0.140233137051498 no 512 0.127112920639334 715 253960
SGTC_1325 1431-0015 227 µM 1.13916086697426 0.140442995930433 no 513 0.127318032121959 634 1103340
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.13872106382993 0.140536836780792 no 514 0.127409757164626 720 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3311 9131146 2.8755 µM 1.13801152983495 0.140688319844223 no 515 0.127557833951518 681 4900406 YPR165W RHO1
SGTC_1386 3228-0095 33.8 µM 1.13795694687495 0.140699977706473 no 516 0.127569230142207 657 870181
SGTC_2835 9006588 71.43 µM 1.13711780328516 0.14087928502295 no 517 0.127744521181002 648 2345538
SGTC_2062 5245942 200 µM 1.13427745829164 0.141487356965329 no 518 0.128339090797559 702 1376160
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.1314951967255 0.14208471610177 no 519 0.128923361981812 686 688664
SGTC_148 3253-0744 288.01 µM 1.12398827246614 0.14370498005853 no 520 0.130509000575211 653 6893655
SGTC_1047 2043-3044 82 µM 1.12385953843585 0.143732873794343 no 521 0.130536309334115 688 669592
SGTC_3077 9117319 49.47 µM 1.12231414702881 0.144068010126424 no 522 0.130864446582077 635 17154678
SGTC_217 ketoconazole 989 nM 1.11840810357921 0.144917429233025 no 523 0.131696367460853 674 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2215 7188065 200 µM 1.1173567048132 0.145146644121876 no 524 0.131920919539897 649 940217
SGTC_628 1636-0253 16 µM 1.11342677240245 0.146005566070155 no 525 0.132762591014171 721 4456143
SGTC_709 3807-1509 243 µM 1.11177627160695 0.146367314054519 no 526 0.13311717827009 695 1886677 YPL242C IQG1
SGTC_25 0118-0223 35.662 µM 1.11044220526569 0.146660147031554 no 527 0.133404259891546 701 5333628
SGTC_208 k072-0098 12.366 µM 1.10979337506176 0.146802709897515 no 528 0.133544037377492 781 5948901
SGTC_1817 st052116 64.4 µM 1.10923792764679 0.146924828260751 no 529 0.133663777400965 679 4361398
SGTC_1305 1181-0477 144 µM 1.10908029017488 0.146959498189529 no 530 0.133697773385566 689 6252086
SGTC_2719 novobiocin 32.65 µM 1.10748466757633 0.147310739585617 no 531 0.134042218840737 627 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_2166 5933061 31.504 µM 1.10668676592422 0.147486591021003 no 532 0.134214689551184 673 2877375
SGTC_2464 5717415 7.67 µM 1.10524697007971 0.147804266779492 no 533 0.134526294668755 692 5285744
SGTC_332 4112-0506 40.9 µM 1.10416145255326 0.148044077475391 no 534 0.134761553875928 699 2790355
SGTC_309 k408-0051 1.48 µM 1.101924899067 0.148538993667678 no 535 0.135247161396042 761 3640463
SGTC_1249 0481-0015 10.2 µM 1.10085767520575 0.148775543965508 no 536 0.135479302670247 637 4227577
SGTC_1501 4491-0275 38.4 µM 1.09871331471841 0.14925160251505 no 537 0.135946566519251 711 5104718
SGTC_797 k781-0471 270 µM 1.09589734551789 0.149878304796687 no 538 0.136561850439596 740 23738129
SGTC_2593 nobiletin 86.24 µM 1.09296616649599 0.150532508976885 no 539 0.137204327505438 641 72344 An anti-infammatory.
SGTC_1892 st058411 7.36 µM 1.09124292453714 0.150918002519538 no 540 0.137583002376514 776 3934738
SGTC_3007 9078383 71.4286 µM 1.08936767808032 0.151338245791655 no 541 0.137995889415761 726 6496995
SGTC_3239 9133757 49.47 µM 1.08843921671171 0.151546602033698 no 542 0.138200628188714 728 17036923
SGTC_2049 5262831 67.185 µM 1.08737204884422 0.151786320891585 no 543 0.138436209401859 712 763417
SGTC_429 1112-0049 25.5 µM 1.08424093455552 0.152491119331987 no 544 0.13912899314682 678 2836170
SGTC_1936 st074407 74.3 µM 1.0830336314444 0.152763456527034 no 545 0.139396747753432 754 809813
SGTC_381 3461-2219 42.7 µM 1.08079325024255 0.153269684366143 no 546 0.139894545799848 755 2883159
SGTC_763 3453-1109 128 µM 1.07692363531346 0.154146662579321 no 547 0.140757191514229 763 1560353
SGTC_650 1328-0195 38 µM 1.07691270629675 0.154149144134383 no 548 0.140759632999153 747 2780821
SGTC_2708 st078559 56 µM 1.07440952835471 0.154718214756851 no 549 0.141319586904546 626 17250902
SGTC_614 0462-0418 107 µM 1.07212129098864 0.155239633853425 no 550 0.141832778507855 668 5188303
SGTC_1712 st032288 53.4 µM 1.06942404976963 0.155855740097156 no 551 0.142439317619822 848 2883011
SGTC_2402 5553605 200 µM 1.06938348115584 0.155865019104775 no 552 0.142448453814561 763 6758546
SGTC_1266 0828-0227 32.9 µM 1.06550604476587 0.156753562003203 no 553 0.143323495812777 694 3913820
SGTC_3167 9103034 49.47 µM 1.06537082759493 0.156784608041928 no 554 0.14335407636002 683 5127859
SGTC_1104 tacrolimus 29.8 µM 1.06422694201516 0.157047407561123 no 555 0.143612952388036 777 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_3124 9127567 49.47 µM 1.06333768872492 0.157251907191943 no 556 0.143814419706044 712 17592030
SGTC_2168 5727979 200 µM 1.06063308656651 0.157874954177098 no 557 0.144428340013961 671 695210
SGTC_671 0560-0003 407 µM 1.05431230998375 0.15933735559269 no 558 0.14586997732247 722 3238678
SGTC_1813 st051246 8.6015 µM 1.05303336251878 0.159634333794294 no 559 0.146162850881588 722 5291959
SGTC_2196 6573537 42.6665 µM 1.05289717362885 0.15966597888358 no 560 0.14619406081297 744 2903087
SGTC_497 capsazepine 133 µM 1.05240296519297 0.159780848496751 no 561 0.146307354420619 729 2733484 A calcium channel blocker.
SGTC_2043 5101342 149 µM 1.05175806706721 0.159930824429983 no 562 0.146455281156328 722 678451
SGTC_1433 4060-0023 7.6 µM 1.05108243710961 0.160088046007307 no 563 0.146610364817642 752 3840627
SGTC_251 melphalan 456.522 µM 1.05081203300412 0.160150998344131 no 564 0.146672464069951 846 460612 A DNA alkylator.
SGTC_1771 st048882 4.1505 µM 1.04937708352601 0.160485337358647 no 565 0.147002300579352 740 4580403
SGTC_1575 cyproterone acetate 48 µM 1.0489108648761 0.160594063011962 no 566 0.14710957225682 718 9880 An androgen receptor antagonist and liver toxin.
SGTC_3134 9127454 49.47 µM 1.04847043148994 0.160696819534983 no 567 0.14721095923276 783 24262820
SGTC_1283 0922-0125 16.4 µM 1.04831795392752 0.16073240373557 no 568 0.147246070206677 803 3360884
SGTC_1336 1486-0901 104 µM 1.04726158824905 0.160979072636057 no 569 0.147489473438891 746 5006114
SGTC_2939 9044578 71.43 µM 1.04708363162642 0.161020651077756 no 570 0.14753050395384 716 2653634
SGTC_2467 5474540 200 µM 1.0438076380183 0.161787318262333 no 571 0.148287198536513 753 5413519
SGTC_2581 avocatin a 64 µM 1.04233172473498 0.162133496086371 no 572 0.148628954370703 771 6710728 A skin care supplement.
SGTC_3198 9112019 49.47 µM 1.03627468632336 0.163559231875165 no 573 0.150037006080086 746 45595555
SGTC_1370 2001-0092 44.6 µM 1.03203860593666 0.164561164584079 no 574 0.151027016252209 877 790957
SGTC_1476 4112-3294 3.34 µM 1.03063041653427 0.164895113566914 no 575 0.151357083389938 768 704369
SGTC_3182 9108849 49.47 µM 1.03001493135271 0.165041212247788 no 576 0.151501498221298 797 17133045
SGTC_236 1509-0011 5.31 µM 1.02844728641343 0.16541370502549 no 577 0.151869737473439 992 3107280
SGTC_2863 9028737 58.44 µM 1.02724857491392 0.165698901098594 no 578 0.152151715259324 758 6460917
SGTC_674 0498-0004 451 µM 1.02674872056761 0.165817919749708 no 579 0.152269400676075 744 4231473
SGTC_946 3434-1334 87.4 µM 1.02461211515541 0.166327282522731 no 580 0.152773122867948 748 4047976
SGTC_198 3454-2873 16.191 µM 1.02437273511302 0.166384413159669 no 581 0.152829627438343 759 710957
SGTC_548 1436-0017 110 µM 1.02340891524238 0.166614567394762 no 582 0.153057272957533 860 9677137
SGTC_1272 0839-0021 27 µM 1.02178950217416 0.167001735656247 no 583 0.153440269499364 798 5027250
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.02082433865499 0.167232762067115 no 584 0.153668835518478 745 279621
SGTC_2328 6201408 200 µM 1.01985765620628 0.167464358453208 no 585 0.153897987084804 744 2890418
SGTC_2331 7980721 200 µM 1.0157837568485 0.168442646599741 no 586 0.15486618632165 796 2981221
SGTC_1709 st033179 39.1045 µM 1.01492833848033 0.168648528872304 no 587 0.155069994283036 810 573381
SGTC_2144 5628481 200 µM 1.01477326344453 0.168685869676272 no 588 0.155106960686824 756 2818399
SGTC_1524 corynanthine 62.1 µM 1.0099642977705 0.169846466239469 no 589 0.15625619768372 777 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_3341 9147222 25.867 µM 1.00784639729782 0.170359220828585 no 590 0.156764103994959 747 1939759
SGTC_605 1315-0399 119 µM 1.00780165547654 0.170370063737121 no 591 0.156774845503036 836 24020461
SGTC_3072 9116419 49.47 µM 1.00748577370951 0.170446628340786 no 592 0.156850695413676 706 17170162
SGTC_1137 ixabepilone 100 µM 1.00646711409071 0.170693684950505 no 593 0.157095461653276 822 154225 A novel microtubule stabilizer.
SGTC_266 formosanin C 406 nM 1.00290796041475 0.171558688793909 no 594 0.157952635722091 796 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_1737 st035557 69.7 µM 0.998874374725044 0.172542376492788 no 595 0.1589277755871 676 5716916
SGTC_3348 9149464 3.537 µM 0.998861433811112 0.172545538225611 no 596 0.158930910454375 795 1951442
SGTC_2681 menadione 3.18 µM 0.997794907439608 0.172806239656417 no 597 0.159189410058692 787 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_3196 9111891 49.47 µM 0.996865862382516 0.173033539671605 no 598 0.159414811896823 789 18891510
SGTC_2302 7771753 200 µM 0.996740061093518 0.173064332829755 no 599 0.159445349444112 806 2203047
SGTC_1614 st002383 48.6 µM 0.996540536676593 0.173113178811346 no 600 0.159493790714461 806 1947235
SGTC_3012 9080433 71.4286 µM 0.995851817748382 0.173281852965066 no 601 0.159661074435801 842 17688859
SGTC_1086 cerivastatin 2.18 µM 0.995264049182046 0.173425886097977 no 602 0.159803928980546 773 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3088 9117578 49.47 µM 0.99384492468173 0.173773957649279 no 603 0.160149185461375 816 678341
SGTC_69 0096-0274 206.684 µM 0.988549934010085 0.175076589403267 no 604 0.161441696013737 880 6741392
SGTC_1864 st057645 30.4 µM 0.988485830358197 0.175092397532816 no 605 0.161457385314487 799 688666
SGTC_276 colchicine 750 µM 0.987863469791304 0.175245920355313 no 606 0.161609759083822 835 2833 A microtubule depolymerizer.
SGTC_316 k060-0003 58.6 µM 0.987244319905019 0.175398735850331 no 607 0.161761439761268 791 6152314
SGTC_2725 haloperidol 53.21 µM 0.987129018365818 0.175427203330812 no 608 0.161789696825387 810 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2405 ticlatone 3.52 µM 0.985519635829215 0.175824859042608 no 609 0.162184445577345 798 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1633 st005664 67.9 µM 0.984927996699193 0.175971188134559 no 610 0.162329720120556 818 2063822
SGTC_1991 st073000 8.92 µM 0.983860393019552 0.176235431779839 no 611 0.162592080056969 858 4301969 YIL048W NEO1
SGTC_3154 9100113 49.47 µM 0.982400802151139 0.176597102677748 no 612 0.162951215654505 803 25237525
SGTC_2059 5238311 157 µM 0.981002920366827 0.176943922424214 no 613 0.163295650708539 790 703021
SGTC_3187 9109394 49.47 µM 0.979027167040698 0.177434847830273 no 614 0.163783278188192 806 17098090
SGTC_2241 6772625 37.8075 µM 0.977362632065829 0.17784910992467 no 615 0.164194827933308 772 2285411
SGTC_3030 9087619 49.47 µM 0.975288625848535 0.178366132270834 no 616 0.164708555437836 830 25236973
SGTC_346 4513-0042 7.16 µM 0.974659071250811 0.178523259084883 no 617 0.164864700747346 842 2827372
SGTC_2814 7977482 42.97 µM 0.97411129980505 0.178660045032488 no 618 0.165000639760361 882 6456762
SGTC_1396 3511-0007 98.6 µM 0.973084428023582 0.178916646585557 no 619 0.165255671350067 735 X1396
SGTC_344 k064-0035 6.43 µM 0.97113228810614 0.179405099511141 no 620 0.165741203531938 802 5088750
SGTC_1960 st011366 51.8 µM 0.97109930871546 0.179413358614435 no 621 0.165749414011728 845 3972846
SGTC_1038 k292-0204 154 µM 0.968339741973827 0.180105289828664 no 622 0.166437361450356 769 4454212
SGTC_1173 0443-0020 122 µM 0.965878579228676 0.180723810811144 no 623 0.167052471112349 824 5331295
SGTC_2252 omeprazole 400 µM 0.96464381310404 0.181034624053268 no 624 0.167361623318577 749 4594 A proton pump inhibitor.
SGTC_2154 5570129 200 µM 0.964225967811705 0.181139879164617 no 625 0.167466323974988 878 673366
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.963944338408218 0.181210843153484 no 626 0.167536916439932 801 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_696 1560-0013 611 µM 0.961282804764552 0.181882346658997 no 627 0.168204995683393 851 1650269
SGTC_1930 st074634 34.3 µM 0.95968816859041 0.182285417083978 no 628 0.168606089821746 821 684253 YOR116C RPO31
SGTC_2126 5251174 33.877 µM 0.95926032219322 0.182393657174336 no 629 0.168713809286439 928 790722
SGTC_2702 st077768 96.8 µM 0.95850933940966 0.182583744033137 no 630 0.168902992160022 758 6484119
SGTC_889 0919-1524 82.7 µM 0.957598014326642 0.182814582423008 no 631 0.169132750420693 793 3905452
SGTC_1619 st003326 88.7 µM 0.955761221020131 0.183280394967537 no 632 0.169596442204031 815 2849032
SGTC_1212 0520-0165 585 µM 0.955250617654161 0.183410015827773 no 633 0.16972548689447 818 5403258
SGTC_183 3914-0051 30.55 µM 0.954661152356017 0.183559727489696 no 634 0.169874540639531 865 1596232
SGTC_1806 st050005 60.3 µM 0.952310062623568 0.184157611684182 no 635 0.170469878013314 822 5194765
SGTC_2475 5812728 15.03 µM 0.952123184169993 0.18420518698626 no 636 0.170517256186548 918 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1513 0337-0559 19 µM 0.950789538854154 0.184544926918355 no 637 0.170855612041444 783 775073
SGTC_95 0471-0001 561.058 µM 0.949543767417252 0.184862633171499 no 638 0.171172061446508 813 4015405
SGTC_2882 9058044 58.44 µM 0.947870166687032 0.185289982477078 no 639 0.171597777128655 831 18076804
SGTC_722 3534-0461 190 µM 0.947583923336424 0.185363135305647 no 640 0.171670656856293 875 658262
SGTC_410 α-linolenic acid 100 µM 0.946378019590431 0.185671514921699 no 641 0.171977906178325 887 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2238 6671620 73.2395 µM 0.944402497998473 0.186177392351339 no 642 0.172482002728972 839 729941
SGTC_2904 7225135 42.03 µM 0.942179424448803 0.18674768151892 no 643 0.173050393139182 919 4446116
SGTC_1663 st014140 55.4 µM 0.94196900423104 0.186801716968184 no 644 0.173104254649158 1002 4207120
SGTC_277 nystatin 15.5 µM 0.94101459715601 0.187046928073948 no 645 0.173348689384196 893 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2117 5521686 200 µM 0.934377881866939 0.188757567929395 no 646 0.175054501449775 833 803312
SGTC_2246 7293507 91.5585 µM 0.932118216059048 0.189342199278569 no 647 0.175637717492029 906 887656
SGTC_1470 k295-0292 231 µM 0.932024784291317 0.1893663963559 no 648 0.175661858554777 907 5045612
SGTC_2384 9036245 200 µM 0.930772921481403 0.189690788942529 no 649 0.175985519827859 904 6462766
SGTC_156 3474-0145 5.642 µM 0.93073356331953 0.189700993279417 no 650 0.175995701752338 869 2265471
SGTC_1078 idebenone 36.1 µM 0.930670140778429 0.189717437465433 no 651 0.176012109896949 911 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_2443 5493264 126.67 µM 0.927657955733162 0.190499445649971 no 652 0.17679251217193 896 5340055
SGTC_1719 st032227 49.2 µM 0.927412017862304 0.190563382067685 no 653 0.176856326633633 872 3125804
SGTC_1112 tnp00069 1.16933 µM 0.924991328747863 0.191193390864031 no 654 0.177485208985293 933 145826
SGTC_2781 5567276 71.43 µM 0.922345187840275 0.191883534740086 no 655 0.178174275286519 837 2853274
SGTC_1248 0469-0687 58.6 µM 0.922340196728314 0.191884837918534 no 656 0.178175576584442 890 4017482
SGTC_3212 9128307 49.47 µM 0.91637655958896 0.193445811167322 no 657 0.179734712670557 766 27243542
SGTC_793 0488-0545 106 µM 0.915930741859962 0.193562813686399 no 658 0.179851610803706 876 292548
SGTC_1901 st060216 58.6 µM 0.915172160925324 0.193761998440673 no 659 0.18005062849654 910 688792
SGTC_1188 1403-0014 4.57 µM 0.914679749716881 0.193891360408263 no 660 0.180179889141599 932 9614867
SGTC_2600 tangeritin 87.95 µM 0.914574045674122 0.193919136911231 no 661 0.180207644625129 833 68077 A bioactive flavone.
SGTC_1728 st035614 33.7865 µM 0.913871802768164 0.194103731173154 no 662 0.180392105807906 942 15945546
SGTC_3053 9095903 49.47 µM 0.912968860094122 0.194341239389375 no 663 0.180629459684513 933 17174018
SGTC_1141 3253-0389 52.6 µM 0.910945187145359 0.194874184542666 no 664 0.181162127536216 896 5402031
SGTC_2448 5185112 27.17 µM 0.910923860929304 0.194879805644847 no 665 0.18116774622166 800 5718189
SGTC_1151 3909-8316 15.3 µM 0.910416791282072 0.195013486634645 no 666 0.181301372857189 891 800431
SGTC_122 0236-0016 402.397 µM 0.909345248709937 0.195296165418989 no 667 0.181583956409925 961 6808838
SGTC_2012 4023501 200 µM 0.908283006448418 0.19557663631752 no 668 0.181864359224647 821 3477460
SGTC_1164 k060-0068 93.7 µM 0.907909166569549 0.195675401905712 no 669 0.181963107090208 969 5963676
SGTC_232 clozapine 119 µM 0.903621769745503 0.19681026237855 no 670 0.183097996869468 896 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1621 st003705 32.4 µM 0.90301229455062 0.196971911489538 no 671 0.183259684923139 962 24207032
SGTC_1469 k284-2957 126 µM 0.902965377724809 0.196984358416284 no 672 0.183272135206943 914 23884841
SGTC_2841 9004761 38.96 µM 0.902792514919409 0.197030222632305 no 673 0.183318012235206 848 2991039
SGTC_347 4534-1311 26.2 µM 0.902213824317208 0.197183808710496 no 674 0.183471646280863 888 2862016
SGTC_1961 st076550 68.7 µM 0.901558178777239 0.197357906339091 no 675 0.183645807704476 850 1579337
SGTC_1129 3453-1384 223 µM 0.900964350736032 0.197515669388829 no 676 0.183803637201076 935 1084452
SGTC_1296 1068-0102 11.9 µM 0.89913272297371 0.198002760334308 no 677 0.184290985029059 909 767053
SGTC_234 nsc-17383 10.7 µM 0.89872871096843 0.198110298185026 no 678 0.184398590107293 965 408974
SGTC_292 k038-0015 474 µM 0.897336975333018 0.198481013151913 no 679 0.184769565919122 895 46368540
SGTC_3332 9141069 11.198 µM 0.896586229262364 0.198681162140563 no 680 0.184969874458993 850 17332883
SGTC_405 ebelactone b 50 µM 0.895982170113244 0.198842292706287 no 681 0.185131142995257 908 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1837 st055472 66.5 µM 0.895002648511701 0.19910374387847 no 682 0.185392836089754 928 676091
SGTC_2192 5915882 198.485 µM 0.894461051735402 0.199248394251365 no 683 0.185537629894183 895 2876149
SGTC_3122 9126309 49.47 µM 0.889041431925744 0.200699355987163 no 684 0.186990406672566 989 17591206
SGTC_2869 9037858 32.47 µM 0.887118557618942 0.201215675997696 no 685 0.187507536922072 938 27187042
SGTC_1833 st055984 71 µM 0.883994281924126 0.202056286249915 no 686 0.188349649788062 903 676288
SGTC_3244 9134489 49.47 µM 0.883966260373078 0.202063835159167 no 687 0.18835721321814 918 16584271
SGTC_1647 st011722 22.4 µM 0.883070879421639 0.202305136549916 no 688 0.18859898837722 888 2854783
SGTC_780 0109-0199 192 µM 0.882335528660262 0.202503439318252 no 689 0.188797694427884 977 610414
SGTC_2750 bromebric acid 70.15 µM 0.877432301369046 0.203828665640838 no 690 0.1901259374167 975 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_154 3389-1638 511.116 µM 0.875293694150458 0.204408295856185 no 691 0.190707062157723 820 5238686
SGTC_1195 1502-0147 41.1 µM 0.875022029376619 0.204481995773911 no 692 0.190780959708252 985 817940
SGTC_2630 antimycin a 100 µM 0.874443706235546 0.204638941677884 no 693 0.190938332183379 1001 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_540 1187-0821 17.3 µM 0.873882125984864 0.204791412443357 no 694 0.19109122478851 921 847520
SGTC_318 1488-0629 67.2 µM 0.872906651267669 0.205056417377884 no 695 0.191356980316982 889 3662576
SGTC_2481 5478948 45.16 µM 0.867373859103177 0.206563350436061 no 696 0.192868600017804 902 77792
SGTC_2369 9071472 200 µM 0.866893092712727 0.206694602891413 no 697 0.19300029423637 947 17296037
SGTC_3184 9108758 49.47 µM 0.866809152928672 0.206717524079265 no 698 0.193023293120932 945 902885
SGTC_2865 9030313 51.95 µM 0.866481888711799 0.206806903519679 no 699 0.193112977094279 863 42562754
SGTC_813 k007-0158 173 µM 0.866224077571272 0.206877330671798 no 700 0.193183645954318 1021 6523916
SGTC_3317 9138495 8.753 µM 0.86584125929786 0.206981932635444 no 701 0.193288609758484 947 17020139
SGTC_1403 3909-7815 62.9 µM 0.863808238299219 0.207537963220476 no 702 0.193846620740257 918 6615483
SGTC_2178 5812956 200 µM 0.863575464382206 0.207601683085217 no 703 0.193910573669261 980 5403383
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.863406968648142 0.207647814559989 no 704 0.193956874659964 992 6708739 YPR165W RHO1
SGTC_3325 9138760 55.175 µM 0.862757963689505 0.207825558466078 no 705 0.194135277858272 925 43844959
SGTC_3057 9095946 49.47 µM 0.860903424374847 0.208333958754801 no 706 0.194645617747724 971 24540043
SGTC_2336 9001819 198.65 µM 0.859200731722898 0.208801377418527 no 707 0.195114889878684 986 2989602
SGTC_1711 st032263 62.8 µM 0.859059903787677 0.208840064778105 no 708 0.195153733654089 932 3958979
SGTC_3027 9089541 49.47 µM 0.857371094836521 0.209304332602693 no 709 0.195619914346386 949 9943819
SGTC_2963 9082507 9 µM 0.856153743282393 0.209639369247375 no 710 0.195956372387675 896 16459611
SGTC_1781 st038725 66.3 µM 0.856071237995415 0.209662087565853 no 711 0.195979188330636 994 4270275 YIL048W NEO1
SGTC_1939 st074455 53.6 µM 0.855347629542748 0.209861399454267 no 712 0.196179363449607 968 1644229
SGTC_694 1315-0438 43.2 µM 0.854648904021803 0.210053963198833 no 713 0.196372772704294 906 6793154
SGTC_2298 7976326 193.81 µM 0.853730627475387 0.210307191433318 no 714 0.196627130004789 900 2235818
SGTC_2125 5246583 200 µM 0.852938055198652 0.210525898926652 no 715 0.196846828342492 1029 835267
SGTC_2131 toluylene red 5.2905 µM 0.851986845088853 0.210788558116719 no 716 0.197110696695475 935 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1026 k007-1105 30.6 µM 0.851546392452708 0.210910246093276 no 717 0.197232951960462 972 7066794
SGTC_2401 5128683 200 µM 0.849982303250729 0.211342704394828 no 718 0.197667462588523 931 708373
SGTC_433 pimozide 108 µM 0.84797420209155 0.211898689309043 no 719 0.198226169060697 888 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_2883 9059145 45.46 µM 0.847192793863582 0.212115269606939 no 720 0.198443834734445 947 16476510
SGTC_2658 polymyxin b sulfate 77.05 µM 0.845722921086636 0.212523019851445 no 721 0.198853666652125 979 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.844818457027687 0.212774150202208 no 722 0.19910610391561 988 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_94 0334-0113 514.748 µM 0.844090597451832 0.212976370908082 no 723 0.199309390733013 976 6795178
SGTC_657 3534-0529 86.7 µM 0.843859474882045 0.213040606977632 no 724 0.199373968017153 1003 1049549
SGTC_1818 st052136 56.3 µM 0.843570303741638 0.213120992446087 no 725 0.199454782222009 928 674169
SGTC_1819 st053448 58.6 µM 0.843417840044478 0.213163382309943 no 726 0.199497398950261 965 2857616
SGTC_1025 k007-0731 70 µM 0.842905775261166 0.213305788953783 no 727 0.199640571664541 965 6256118
SGTC_2570 licareol 100 µM 0.842422382523779 0.213440272705214 no 728 0.199775784423909 911 443158
SGTC_491 tetrandrine 80.3 µM 0.841961270163405 0.213568603920238 no 729 0.199904816325529 951 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_553 k007-0256 45.7 µM 0.841108038058723 0.213806183687951 no 730 0.200143706227683 1002 6287000
SGTC_2999 9069765 71.4286 µM 0.839529458113795 0.214246139815872 no 731 0.200586132834302 1019 2097066
SGTC_2591 skatole 100 µM 0.839082169034186 0.214370896644252 no 732 0.200711600669955 972 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_717 1532-0246 73.2 µM 0.83892037582207 0.214416034033315 no 733 0.200756996440928 968 9561992
SGTC_1902 st060212 70.5 µM 0.837708722684186 0.214754239042974 no 734 0.201097156661188 1046 688944
SGTC_1840 st055363 71 µM 0.836994572086174 0.214953722802647 no 735 0.201297809537472 916 676033
SGTC_3059 1327-0034 3 µM 0.836806140544065 0.215006375342558 no 736 0.201350772620925 946 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_734 2023-0417 80 µM 0.836637617169191 0.215053471380489 no 737 0.201398147124211 967 3935732
SGTC_2473 5854593 8.94 µM 0.836506724122987 0.215090055268693 no 738 0.201434947774532 944 2872951
SGTC_1124 fisetin 1.16336 µM 0.834708283417105 0.215593075335886 no 739 0.201940988307061 938 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_1114 scopoletin 1.73284 µM 0.833668477818094 0.215884217718771 no 740 0.202233912947641 1002 5280460 A coumarin with genotoxic properties.
SGTC_342 k048-0088 23.3 µM 0.833465156865732 0.215941173581338 no 741 0.202291220385646 993 6820570
SGTC_1910 st062352 60.4 µM 0.833456279547133 0.215943660563916 no 742 0.202293722741511 1012 2245730
SGTC_3151 9099821 49.47 µM 0.832654765680547 0.216168273215779 no 743 0.202519731325187 986 17174189
SGTC_1783 st039459 87.517 µM 0.831427447256045 0.216512473488323 no 744 0.20286609945615 1051 729761
SGTC_321 4534-3890 65.3 µM 0.831190360777178 0.216579000690362 no 745 0.202933049664451 1027 699746
SGTC_1557 sumaresinolic acid 42.3 µM 0.829963057723769 0.216923574741124 no 746 0.203279835365821 961 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_683 panaxydol 45 µM 0.82832280352067 0.217384582153856 no 747 0.203743855963484 1008 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_917 harmaline 728.087 nM 0.826918178425847 0.21777981324641 no 748 0.204141719594961 988 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2319 6033012 152.6 µM 0.826413370659513 0.217921956413596 no 749 0.204284820642679 928 847246
SGTC_205 1486-1330 71.903 µM 0.826236263635929 0.21797183867198 no 750 0.204335040439982 978 4118834
SGTC_940 3232-1287 54.8 µM 0.826218509226266 0.21797683957103 no 751 0.204340075218499 1013 1585493 YIL048W NEO1
SGTC_2204 7233102 200 µM 0.826170726485975 0.217990298903053 no 752 0.204353625769164 949 2172480
SGTC_486 niguldipine 82 µM 0.825911237606368 0.218063399497846 no 753 0.204427222710168 957 1236 A calcium channel blocker.
SGTC_1456 k015-0012 13 µM 0.825601719846733 0.218150612202223 no 754 0.204515029607654 1080 2989616
SGTC_1003 4049-0218 100 µM 0.823543382603227 0.218731100240331 no 755 0.205099528705051 1009 295161
SGTC_558 k064-0027 21.3 µM 0.820770884519494 0.219514397840292 no 756 0.205888392925166 1020 5088526
SGTC_2406 ethylparaben 405.7 µM 0.81982363076365 0.219782388733837 no 757 0.206158328865819 874 8434 A possible steroid mimic.
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.819213389407636 0.219955133687333 no 758 0.206332338507915 1037 688751
SGTC_1113 artemisinin 1.17947 µM 0.819213000170478 0.219955243896061 no 759 0.206332449526226 1047 2240 An anti-malaria and mitochondrial poison.
SGTC_627 1391-0720 175 µM 0.818080340549132 0.220276079661626 no 760 0.206655656872806 979 997839
SGTC_2390 9097792 176.6 µM 0.817506932878616 0.220438604659469 no 761 0.206819394477766 957 4497149
SGTC_1162 k048-0130 20.1 µM 0.816606724818646 0.220693895598483 no 762 0.207076605395308 992 6797406
SGTC_231 b-estradiol 524 µM 0.815279544693192 0.221070580685494 no 763 0.207456157394098 959 450 A steroid.
SGTC_2979 9012552 45.46 µM 0.813838453665364 0.221480012707177 no 764 0.207868751378175 987 17100905
SGTC_2463 5473429 200 µM 0.813062121036635 0.221700758080283 no 765 0.208091221286042 986 5399405
SGTC_2988 9073640 71.4286 µM 0.811231141039225 0.222221883462883 no 766 0.2086164726646 976 9102229
SGTC_2424 5537928 59.2 µM 0.81121665403907 0.22222600947366 no 767 0.208620631649654 1074 5382802
SGTC_2056 5235370 200 µM 0.810031818749028 0.222563607776437 no 768 0.208960944270622 963 5511916
SGTC_938 3126-1755 342 µM 0.809965379892872 0.222582547032462 no 769 0.208980036753093 1062 1777771
SGTC_2720 fluspirilene 36.88 µM 0.809943606282094 0.222588754081985 no 770 0.208986294042242 963 3396 An atypical antipsychotic.
SGTC_46 0329-0187a 2.197 µM 0.804512658795983 0.224140044947316 no 771 0.210550480759423 1063 46494817
SGTC_2626 ethyl orsellinate 100 µM 0.802017744312499 0.224854743224009 no 772 0.211271347010415 1026 75653 A natural product.
SGTC_2395 5646831 180.19 µM 0.801385892964515 0.225035949466252 no 773 0.211454139708875 1013 6808628
SGTC_1880 MG-132 525 µM 0.799969926310347 0.225442329517058 no 774 0.211864110782051 990 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1170 0310-0127 64.8 µM 0.799056747737172 0.225704630436727 no 775 0.212128753879763 1042 774975
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.797665091895159 0.226104700762984 no 776 0.212532433251592 1100 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3249 9135183 49.47 µM 0.79590972911436 0.22660989991096 no 777 0.213042252964129 1065 4902779
SGTC_2171 5739187 198.077 µM 0.795424651046842 0.226749619245587 no 778 0.213183262591384 1015 2262761
SGTC_454 lyso-paf C-16 6.67 µM 0.792894389806621 0.227479209927165 no 779 0.213919678115134 1045 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_803 4488-1585 147 µM 0.790614898229022 0.228137622766675 no 780 0.214584375171586 1021 747204
SGTC_2143 5623677 140.463 µM 0.790000457835333 0.228315282115376 no 781 0.214763750474014 1042 5375313
SGTC_101 0490-5701 117.494 µM 0.787982829846024 0.228899205795479 no 782 0.21535337464372 994 4661669
SGTC_1011 4112-3381 17.4 µM 0.787755379788655 0.228965084863399 no 783 0.215419902668827 1046 2877139
SGTC_2030 5175110 200 µM 0.787460595368389 0.229050482611881 no 784 0.215506143401666 1080 2831986
SGTC_1464 k208-0027 110 µM 0.787087131738005 0.229158699034828 no 785 0.2156154309013 1054 X1464
SGTC_3172 9105863 49.47 µM 0.784469589867697 0.229917973456365 no 786 0.216382309478689 1039 2348785
SGTC_1048 3161-0300 24.5 µM 0.784333563726908 0.229957469223637 no 787 0.216422205062191 1123 2165101
SGTC_305 1682-2595 20.8 µM 0.783803365599315 0.230111450741491 no 788 0.216577749357132 1070 226033
SGTC_1161 k007-0610 110 µM 0.783168664938489 0.230295857995487 no 789 0.216764036596414 1124 5843850
SGTC_742 0kpi-0133 140 µM 0.782206999385625 0.230575419713151 no 790 0.217046465842429 1078 2728852
SGTC_1321 1326-2144 215 µM 0.781067714983267 0.230906861536461 no 791 0.217381334568899 1068 3513030
SGTC_3300 9124615 50.48 µM 0.780895105849356 0.2309571003628 no 792 0.217432095408402 1060 24824903
SGTC_1447 4239-0816 81.9 µM 0.779935940574812 0.231236381770473 no 793 0.217714291067774 1013 1341554
SGTC_708 3448-5400 146 µM 0.779686133364797 0.231309149374742 no 794 0.217787821421698 1084 3462195
SGTC_2223 6903751 107.57 µM 0.779534314541598 0.231353379686087 no 795 0.217832516047803 1012 5598863
SGTC_224 benfluorex 43.875 µM 0.778251159112529 0.231727397598334 no 796 0.218210481197339 1067 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.778196489544891 0.231743340323701 no 797 0.218226593006811 1175 688801
SGTC_173 1273-0061 2.693 µM 0.777559986362486 0.231929002189963 no 798 0.21841422894782 1052 2847414 YPL266W DIM1
SGTC_979 1426-2828 121 µM 0.77755911965658 0.231929255056214 no 799 0.218414484508978 1110 747872
SGTC_3315 9136395 68.55 µM 0.77579512600566 0.232444228015576 no 800 0.218934981119514 1122 16876844
SGTC_2348 9022543 33.42 µM 0.77532414815937 0.232581830810974 no 801 0.219074071806564 1055 3162678 YDL140C RPO21
SGTC_698 k064-0052 127 µM 0.774313554339514 0.23287724278211 no 802 0.219372695043348 1106 5088751
SGTC_68 0986-0284 82.829 µM 0.769311963641226 0.234342348383061 no 803 0.220854068367729 937 423278 YIL048W NEO1
SGTC_2980 9014342 25.29 µM 0.767128115109482 0.234983655035839 no 804 0.221502673658961 1023 2996599
SGTC_1338 1486-1223 76 µM 0.76630606577392 0.235225308143316 no 805 0.221747104966576 1095 3444526
SGTC_245 methotrexate 289.6 µM 0.765135194131985 0.235569739324418 no 806 0.222095522352221 1084 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1280 0880-0253 10.1 µM 0.763792642858192 0.23596501507562 no 807 0.22249541091397 1067 6836607
SGTC_641 4092-0595 30 µM 0.761510199814785 0.236637853169476 no 808 0.223176194481051 1104 786260
SGTC_2689 tacrolimus 100 µM 0.761142012959777 0.236746489218752 no 809 0.223286124427425 1067 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_666 0272-0154 136 µM 0.759952708936652 0.237097588829181 no 810 0.223641426685468 1100 6870312
SGTC_2445 5742597 35.57 µM 0.759775583109737 0.237149903381741 no 811 0.223694370173047 1045 1774255
SGTC_866 0495-0101 262 µM 0.758137924054365 0.237633890296503 no 812 0.224184209208644 1030 635694
SGTC_501 nsc-95397 161 µM 0.757268484624638 0.237891060876851 no 813 0.224444513956241 1073 262093
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.757155256137603 0.237924563840411 no 814 0.224478426478848 1079 390807
SGTC_2950 9072895 21.46 µM 0.756245672082547 0.238193792791358 no 815 0.224750957124402 1096 17332245
SGTC_823 0417-1665 178 µM 0.756224536767047 0.238200050644196 no 816 0.224757291942262 1112 3429856
SGTC_482 fipronil 114 µM 0.755928977275456 0.238287570854105 no 817 0.22484588961372 1116 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_896 0964-0007 44.5 µM 0.755859994308178 0.238308000423113 no 818 0.224866570974577 1120 6756758
SGTC_3153 9100258 49.47 µM 0.755741047285556 0.238343229290965 no 819 0.224902234285634 1037 25236848
SGTC_1459 k035-0031 35.7 µM 0.75482673996263 0.238614117414112 no 820 0.225176473652388 984 3877128 YMR208W ERG12
SGTC_99 0109-0120 622.8 µM 0.754556774617145 0.238694134113897 no 821 0.2252574838661 1094 759414
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.754454511369988 0.238724448384441 no 822 0.225288174957407 1121 6312947
SGTC_2237 6667747 47.222 µM 0.751732499825382 0.239532118010079 no 823 0.226105970897508 1035 729940 YDL015C TSC13
SGTC_2165 5727197 32.143 µM 0.751074991469796 0.239727435992668 no 824 0.226303762731971 1177 1361712
SGTC_703 3875-0075 71.8 µM 0.750932487111565 0.239769779479246 no 825 0.226346643813622 1154 2850814
SGTC_1850 st056238 17 µM 0.750726638783214 0.239830952082325 no 826 0.226408593873659 1157 5393177
SGTC_413 propylparaben 100 µM 0.749315258101624 0.24025060579449 no 827 0.22683360673481 1091 7175 A pharmaceutical preservative.
SGTC_1705 st027868 56.3335 µM 0.748372092888944 0.24053126526867 no 828 0.227117875313722 1140 292948
SGTC_1724 st037281 8.293 µM 0.746524834732408 0.241081474264841 no 829 0.227675217585197 1124 574124 YDL195W SEC31
SGTC_925 2064-1272 59.6 µM 0.745523725153516 0.241379942138649 no 830 0.227977587024257 1053 6815817
SGTC_1014 4130-3005 69.3 µM 0.743819092371928 0.241888617949733 no 831 0.228492964012306 1152 743608
SGTC_509 pifithrin 175 µM 0.741763491564496 0.242502798086923 no 832 0.229115321946466 1170 4817 A p53 inhibitor.
SGTC_3263 9137018 49.47 µM 0.740808092012434 0.242788543221567 no 833 0.229404904023301 1091 43844957
SGTC_1979 st071809 45.3 µM 0.739990822654327 0.243033120305938 no 834 0.229652781482576 1133 4976333
SGTC_300 r073-0011 5.04 µM 0.735762024958252 0.244300761715735 no 835 0.230937767759704 1176 2735780
SGTC_588 3970-1144 52.9 µM 0.735610321458669 0.24434630309208 no 836 0.23098393970407 1074 1888707
SGTC_1269 0831-0796 3.05 µM 0.734828532530668 0.244581068583838 no 837 0.231221963926462 1123 927758
SGTC_472 calcifediol 10 µM 0.733907941150819 0.244857671118627 no 838 0.231502423436304 1087 5283731 A vitamin D metabolite.
SGTC_769 0302-0231 76 µM 0.733053931991481 0.245114418697431 no 839 0.231762768060117 1155 571869 YER009W NTF2
SGTC_3033 9090887 49.47 µM 0.732562655722378 0.245262180574114 no 840 0.231912607467049 1158 19325384
SGTC_2397 5161689 200 µM 0.732432812879793 0.245301241593644 no 841 0.231952218584281 1147 2259942
SGTC_109 0132-0036 33.701 µM 0.731901025233712 0.245461255787042 no 842 0.232114490190154 1027 67274 A color developer.
SGTC_1848 st056003 16.4 µM 0.729339844320996 0.246232696600679 no 843 0.23289690258029 1212 146492
SGTC_3115 9123671 49.47 µM 0.728268884707232 0.246555660148078 no 844 0.233224502761248 1242 3286988
SGTC_1579 chlormadinone acetate 49.4 µM 0.727969495920509 0.246645985788437 no 845 0.233316129735419 1170 45114258 A steroidal progestin.
SGTC_1071 trifluoperazine 6.31 µM 0.727887232427162 0.246670807799813 no 846 0.233341309710627 1163 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1770 st043884 66.3 µM 0.727518133765666 0.246782195309378 no 847 0.233454305420273 1156 670149
SGTC_3256 9138902 49.47 µM 0.726731367130466 0.247019717545846 no 848 0.233695267104251 1178 17228773
SGTC_2329 6138490 200 µM 0.726255253397256 0.247163514084932 no 849 0.233841152588344 1052 720019
SGTC_2695 st077686 51.995 µM 0.726167376394432 0.247190059714041 no 850 0.233868084399837 1151 2876092
SGTC_2290 7904846 200 µM 0.725332468175274 0.247442342395664 no 851 0.234124045832593 1171 2962154
SGTC_2412 st077135 33.4 µM 0.724963819696691 0.247553780004182 no 852 0.234237113346241 1161 13258915
SGTC_2263 7948595 193.29 µM 0.72354300420948 0.24798352460867 no 853 0.23467317175393 1089 2971371
SGTC_2271 7849410 118.62 µM 0.722845879231456 0.248194524847215 no 854 0.23488728842536 1157 972430
SGTC_256 clotrimazole 625 nM 0.721045158350283 0.248739995480561 no 855 0.235440865553849 1132 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1377 2944-0135 198 µM 0.719730797928736 0.249138541468262 no 856 0.235845380007295 1182 1894137
SGTC_3141 9094609 49.47 µM 0.719235551494591 0.249288800265575 no 857 0.23599789896909 1117 25236309 YDL196W YDL196W
SGTC_2673 kobusone 100 µM 0.718731499062515 0.249441780282411 no 858 0.236153185671518 1216 6710676 An epoxy ketone and protein crosslinker.
SGTC_1074 carmofur 3.8 µM 0.718666710429646 0.249461447263806 no 859 0.23617314960729 1202 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2205 7238770 200 µM 0.717920756185483 0.249687945537528 no 860 0.236403074516826 1169 279867
SGTC_1094 duloxetine 25.4 µM 0.716982341132559 0.249973036815789 no 861 0.236692496399396 1159 60834 A selective serotonin reuptake inhibitor.
SGTC_1626 st003712 1.76 µM 0.714902601716925 0.250605478519642 no 862 0.237334614633277 1131 24207035
SGTC_3273 9137859 49.47 µM 0.714188666218539 0.250822779152081 no 863 0.237555262119875 1219 2377234
SGTC_1571 st070080 73.4 µM 0.712436185467435 0.251356604598586 no 864 0.238097357373493 1175 4315245
SGTC_47 0149-0135 24.25 µM 0.711143534446129 0.251750745254535 no 865 0.238497647449367 1148 5239155
SGTC_1148 3909-7663 27.7 µM 0.709282379131579 0.252318800549982 no 866 0.239074630495913 1218 4084526
SGTC_1526 st051518 75 µM 0.708541928566738 0.252544986027449 no 867 0.239304392063101 1094 673993
SGTC_1382 3002-2117 298 µM 0.708504310656728 0.252556480023381 no 868 0.239316068107181 1221 1497314
SGTC_2249 haloperidol 116.36 µM 0.70756278649616 0.252844248562663 no 869 0.239608404656569 1199 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_3245 9134821 49.47 µM 0.703076584848803 0.254217783520523 no 870 0.241004011733696 1164 17014901
SGTC_2730 imipramine 71.33 µM 0.702392334446819 0.254427622997853 no 871 0.241217262233888 1201 3696 A tricyclic antidepressant.
SGTC_1271 0832-2808 169 µM 0.701741247980141 0.254627376316688 no 872 0.241420272190031 1200 3663794
SGTC_672 1441-0018 53.7 µM 0.701675448346243 0.254647568212473 no 873 0.24144079379923 1161 251141
SGTC_1067 clotrimazole 1.36 µM 0.699082429226807 0.25544395369141 no 874 0.242250259299878 1217 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2690 usnic acid 100 µM 0.694000375939495 0.257008554733882 no 875 0.243840986579714 1240 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.691346063913171 0.257827709498749 no 876 0.244674045186175 1204 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_937 3122-0005 46.7 µM 0.690865775470039 0.257976077311228 no 877 0.244824947788693 1197 759535
SGTC_2856 9022925 19.48 µM 0.690721672934437 0.258020601234364 no 878 0.24487023336512 1192 4944862
SGTC_1949 st076024 69.1 µM 0.690556921876369 0.258071509894876 no 879 0.244922013456665 1199 2921930
SGTC_519 k048-0011 62.8 µM 0.690233096565916 0.258171588242065 no 880 0.245023806629283 1188 6836379
SGTC_1331 1472-0049 76.2 µM 0.688162288716697 0.258812047681755 no 881 0.245675294460746 1190 24051409
SGTC_362 0310-0100 9.03 µM 0.686940276498152 0.259190376990029 no 882 0.246060182386269 1227 790235
SGTC_354 2783-3500 4.88 µM 0.686681215341506 0.259270617830618 no 883 0.246141818450246 1189 6740761
SGTC_1209 2323-2347 50.3 µM 0.684801795087863 0.259853128088051 no 884 0.246734501230541 1196 5412760
SGTC_3333 9141820 12.094 µM 0.684793413867276 0.259855727287175 no 885 0.246737145992715 1193 1939433
SGTC_2786 7743617 45.45 µM 0.682515786696569 0.260562565859143 no 886 0.247456431962172 1145 583674
SGTC_65 0798-0905 34.986 µM 0.681874243109752 0.260761840952617 no 887 0.247659236686176 1327 3602145
SGTC_1480 1070-0044 41.2 µM 0.680735316038644 0.261115805469454 no 888 0.248019492822777 1214 3124987
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.678496859226955 0.261812209275346 no 889 0.248728357274021 1250 165506
SGTC_3037 9091026 49.47 µM 0.67741617357868 0.262148760858479 no 890 0.249070969715333 1236 25236398 YIL048W NEO1
SGTC_2489 cantharidin 73.42 µM 0.676574284327751 0.262411099020533 no 891 0.249338049826552 1213 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3303 9125618 40.5795 µM 0.676084591946455 0.262563752158839 no 892 0.249493469356847 1247 22695467
SGTC_1545 lovastatin 49.4 µM 0.675930628274005 0.262611757062898 no 893 0.249542345284743 1271 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_2385 9074692 200 µM 0.675439808892746 0.262764821432011 no 894 0.249698190359804 1213 17046906
SGTC_1240 0356-0016 42.1 µM 0.674490759476595 0.263060916395856 no 895 0.249999679274407 1202 4305613
SGTC_1600 coumarin 106 71.1 µM 0.67405514990827 0.263196879771647 no 896 0.250138126029291 1270 100336 A hepatotoxic, DNA x-linker.
SGTC_151 3013-0144 2.285 µM 0.668332924247935 0.264986239752845 no 897 0.251960550662569 1204 906558 YHR107C CDC12
SGTC_1054 3429-0080 167 µM 0.668151545557806 0.26504305840745 no 898 0.252018430823378 1254 1162877
SGTC_3087 9117406 49.47 µM 0.667354090097052 0.265292942561571 no 899 0.252272991831229 1230 42546093
SGTC_1306 1185-0270 9.02 µM 0.667226140980451 0.265333046786576 no 900 0.252313847928722 1234 1548076
SGTC_406 estrone 100 µM 0.664248296758812 0.266267287269395 no 901 0.253265703336744 1270 5870 A steroid.
SGTC_2771 fluoxetine 41.05 µM 0.663756627214163 0.266421698981055 no 902 0.253423044845817 1252 3386 A selective serotonin reuptake inhibitor.
SGTC_3163 9099914 49.47 µM 0.660316853393554 0.267503245789145 no 903 0.254525258517646 1272 16268368
SGTC_358 0075-0058 9.45 µM 0.659863965133963 0.26764580940612 no 904 0.254670565295277 1271 1069125
SGTC_1091 telmisartan 47.6 µM 0.658086583413672 0.268205676978079 no 905 0.255241248246132 1315 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1107 amlodipine 47 µM 0.657295221592222 0.268455141998715 no 906 0.255495554197825 1158 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_598 3937-0236 20.2 µM 0.656458287931076 0.268719099738444 no 907 0.255764648726123 1280 1379313
SGTC_766 1391-0721 126 µM 0.655248239158592 0.269100963416394 no 908 0.256153970282798 1271 1020919 YIL115C NUP159
SGTC_1560 lithocholic acid 53.1 µM 0.655062475316947 0.26915961033125 no 909 0.256213765363396 1212 9903 A bile acid which acts as a detergent.
SGTC_1172 0370-0043 85 µM 0.654051870119818 0.269478777596121 no 910 0.256539194109517 1295 376585
SGTC_96 0929-0093 37.281 µM 0.653510368701906 0.269649871482799 no 911 0.256713653547699 1237 6991579
SGTC_1346 1488-2224 62.4 µM 0.651879845643284 0.270165383264703 no 912 0.257239343759838 1264 3722427
SGTC_1791 st048313 56.1 µM 0.650960383868891 0.270456300662648 no 913 0.257536030203118 1217 1204976
SGTC_1573 oleylamine 1.06 µM 0.650797867377166 0.2705077371012 no 914 0.257588488532703 1275 5356789 An amine of the fatty acid oleic acid.
SGTC_2439 5492030 7.2 µM 0.650414146166166 0.270629204181755 no 915 0.257712371046999 1233 5722370
SGTC_481 bay k-8644 50 µM 0.64948409192201 0.270923726154201 no 916 0.25801276278879 1210 2303 A calcium channel antagonist.
SGTC_1473 k844-0725 134 µM 0.648955109508323 0.271091311302327 no 917 0.258183696119558 1317 54682906
SGTC_2265 7929201 200 µM 0.648314916531529 0.271294197818451 no 918 0.258390644092657 1265 1265108
SGTC_1035 k081-0041 55.2 µM 0.647224495133751 0.271639942443771 no 919 0.258743330093877 1290 731709
SGTC_2114 5491910 81.25 µM 0.646198150766889 0.271965570183519 no 920 0.259075518495681 1324 2849228
SGTC_2987 9018338 71.43 µM 0.646000727919 0.272028228684192 no 921 0.259139441997702 1324 5055682
SGTC_1745 st081495 74 µM 0.643597000821133 0.272791704220937 no 922 0.259918397799832 1227 13842402 YBL026W LSM2
SGTC_1041 0206-0046 107 µM 0.642424271361545 0.273164573811355 no 923 0.260298872344904 1294 50494
SGTC_1115 galangin 695.678 nM 0.640934003458223 0.27363876890254 no 924 0.260782781183191 1316 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_476 mead acid 10 µM 0.640246204096236 0.273857760175577 no 925 0.261006274337709 1306 5312531 An omega 9 fatty acid.
SGTC_2010 4012422 159 µM 0.63944112324297 0.274114203213351 no 926 0.261268001921179 1282 952393
SGTC_1231 0242-0792 125 µM 0.639039357420437 0.274242222356087 no 927 0.261398664309515 1274 3707635
SGTC_2936 9038235 15.59 µM 0.638556563125524 0.274396099556197 no 928 0.261555723181602 1276 4749415
SGTC_1144 3486-0183 12.5 µM 0.637095362403647 0.274862076001595 no 929 0.262031364588556 1298 6744069
SGTC_729 4092-0585 94.1 µM 0.636449178433057 0.275068268166051 no 930 0.262241847873115 1264 2169061
SGTC_2704 st078022 71.1 µM 0.636228657125227 0.275138652193321 no 931 0.262313698704302 1314 54697681
SGTC_1510 1123-0200 71.5 µM 0.635443389228517 0.275389359003964 no 932 0.26256963860565 1385 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1974 st069448 26.9 µM 0.633395592341453 0.276043672617718 no 933 0.263237671304193 1260 6323587 YNR016C ACC1
SGTC_2347 9049783 174.81 µM 0.632030559236179 0.276480252630945 no 934 0.26368345438258 1301 6467988 YPL169C MEX67
SGTC_912 3474-0017 2.18 µM 0.630975580361016 0.276817899450349 no 935 0.264028245713972 1360 3360550
SGTC_3206 9114350 49.47 µM 0.628404359039017 0.277641665864461 no 936 0.264869541124358 1252 17087243
SGTC_1779 st039427 55 µM 0.628031810232079 0.277761122091481 no 937 0.264991550822792 1381 1124498
SGTC_113 0099-0221 2.5 µM 0.625776751716744 0.27848473251579 no 938 0.265730691341653 1362 89219
SGTC_2793 7325131 81.82 µM 0.625551314254174 0.278557122078248 no 939 0.265804640404557 1309 4176441
SGTC_3009 9080819 71.4286 µM 0.623337470631786 0.279268489439979 no 940 0.266531389592529 1289 17027216
SGTC_2354 9060492 162 µM 0.623329129942217 0.279271171195757 no 941 0.266534129530167 1317 6471895
SGTC_732 3970-1727 52.7 µM 0.621093102175713 0.279990565218003 no 942 0.26726918374251 1327 1275699
SGTC_865 0488-0499 301 µM 0.620200693637891 0.280277929169689 no 943 0.267562832452877 1321 9634651
SGTC_3354 9151612 71.43 µM 0.619693255107855 0.280441392838039 no 944 0.267729878568403 1313 27261949
SGTC_1827 berberine 7.24 µM 0.618942979973374 0.280683167189197 no 945 0.267976961484307 1224 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2778 tioconazole 65.09 nM 0.618275225110927 0.280898434348642 no 946 0.268196965099355 1275 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 0.617553455989707 0.281131204041044 no 947 0.268434866831508 1338 368090
SGTC_1318 1280-3875 124 µM 0.616787466529372 0.281378336599544 no 948 0.268687460002032 1316 373245
SGTC_291 SEC14.278 35.5 µM 0.616644851919681 0.28142436018285 no 949 0.268734501869892 1320 1068044
SGTC_53 0973-0023 39.979 µM 0.616329586718342 0.28152611323914 no 950 0.268838507747403 1303 674768
SGTC_1996 st072960 66.8 µM 0.616221585153796 0.281560975240271 no 951 0.268874142073202 1298 1719405
SGTC_345 1362-0200 395 µM 0.615654982374523 0.281743903984355 no 952 0.269061127366136 1293 1419823
SGTC_165 k038-0023 64.381 µM 0.614931011243953 0.281977722722669 no 953 0.269300140913523 1293 46368543
SGTC_2504 purpurogallin 52.29 µM 0.614576266090532 0.282092327787979 no 954 0.269417296177711 1291 5281571 An antioxidant.
SGTC_283 0987-0079 11.7 µM 0.613188290116393 0.282540947006592 no 955 0.269875923305568 1335 411556
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.612281092802085 0.282834355016842 no 956 0.270175898419264 1311 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1070 indatraline 8.81 µM 0.611673950915633 0.283030800065708 no 957 0.270376749898897 1304 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2586 curcumin 80 µM 0.609758198590127 0.283651084264766 no 958 0.271010997865614 1362 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2363 9053361 176 µM 0.609464730290179 0.283746161208733 no 959 0.271108221907189 1408 6469797 YMR079W SEC14
SGTC_1754 st042065 16.137 µM 0.60934441309896 0.283785145607266 no 960 0.271148087197014 1274 1126236 YIL048W NEO1
SGTC_1309 pyrazolanthrone 13.4 µM 0.608371570375445 0.28410045397983 no 961 0.271470531314873 1367 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_879 0831-1030 162 µM 0.60835154807024 0.284106945175133 no 962 0.271477169618717 1328 1549252
SGTC_1769 st044406 64.4 µM 0.607927748032354 0.284244357022686 no 963 0.271617697551878 1332 670903
SGTC_2277 7947813 106.88 µM 0.607608832859358 0.284347782214487 no 964 0.271723470570956 1404 1246798
SGTC_3127 9126946 49.47 µM 0.606200981795512 0.284804567541398 no 965 0.272190650459574 1284 27243249
SGTC_1613 st002381 52.1 µM 0.605691555994608 0.284969939884729 no 966 0.272359796118427 1321 551167
SGTC_2334 9017922 200 µM 0.604397878498276 0.285390105611016 no 967 0.272789572951717 1386 3163164
SGTC_2540 epiandrosterone 100 µM 0.603300212425972 0.285746841169955 no 968 0.273154495834888 1396 441302 A steroid.
SGTC_1128 3448-9350 235 µM 0.603055104891491 0.285826528758277 no 969 0.273236015709578 1330 619386
SGTC_580 1123-0028 41 µM 0.601915600117196 0.286197135006113 no 970 0.27361515974396 1379 1677248 YPR107C YTH1
SGTC_2442 5158906 48.48 µM 0.601123741340485 0.286454809119186 no 971 0.27387878577681 1408 1893835
SGTC_2175 5807670 165.306 µM 0.60112043415881 0.286455885520561 no 972 0.273879887068719 1293 241186
SGTC_2614 arthonioic acid 13.39 µM 0.599166647555805 0.287092127352633 no 973 0.274530880691754 1279 6710684
SGTC_2118 5526350 200 µM 0.599128740163113 0.287104478339272 no 974 0.274543518824325 1384 743594
SGTC_1792 st045773 43.6 µM 0.59892003688337 0.287172482546868 no 975 0.274613104579939 1308 2919270
SGTC_2606 farnesol 9.78 µM 0.597409049179365 0.287665052472446 no 976 0.275117156772823 1393 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2313 7726885 200 µM 0.597199101954807 0.287733525172363 no 977 0.275187229353646 1334 726423
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.596693065300379 0.287898596843034 no 978 0.275356161689096 1365 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1926 methyl fluorone black 53.6 µM 0.596446248193469 0.287979126031312 no 979 0.275438576189069 1221 72721 Reacts with homocysteine.
SGTC_3052 9092717 49.47 µM 0.595982234250807 0.288130548962379 no 980 0.275593547552983 1331 25237534
SGTC_2203 7227154 166.4 µM 0.593989742076078 0.28878119098799 no 981 0.276259486956157 1332 896304
SGTC_597 k018-0003 82.8 µM 0.593930546383882 0.288800531730186 no 982 0.276279283669131 1445 6786234
SGTC_20 0481-0013 4.944 µM 0.593142339434186 0.289058117138569 no 983 0.276542948674253 1321 182045
SGTC_1467 k284-1082 293 µM 0.593117590682344 0.289066206760559 no 984 0.276551229435864 1392 3334705
SGTC_2229 7354935 190 µM 0.592479393748933 0.289274850894485 no 985 0.276764807699173 1313 318112
SGTC_2122 5258151 111.688 µM 0.592170304987391 0.289375925948189 no 986 0.276868276030716 1329 2173356
SGTC_3241 9133421 49.47 µM 0.591247146338635 0.289677906616976 no 987 0.277177418717316 1360 17018221
SGTC_1982 st072467 71.9 µM 0.591054742193057 0.28974086385922 no 988 0.277241871301917 1345 3163533
SGTC_1365 1672-3266 55.4 µM 0.589821066871692 0.290144691619292 no 989 0.27765530866579 1352 6415873
SGTC_36 0335-0881 14.2 µM 0.588980967714375 0.290419838144895 no 990 0.277937020475585 1308 23828853
SGTC_2831 7999036 19.48 µM 0.588404737544929 0.290608633761629 no 991 0.278130329293124 1469 2988270
SGTC_1301 naphtanilide LB 4.81 µM 0.588313845704365 0.290638418737543 no 992 0.278160826904741 1435 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_2976 9009005 19.48 µM 0.588110494316797 0.290705061531243 no 993 0.278229064805703 1404 2993148
SGTC_3186 9110464 49.47 µM 0.588102872477315 0.290707559517304 no 994 0.278231622597927 1382 17018021
SGTC_1655 st012546 55.1 µM 0.58748644127553 0.290909622264062 no 995 0.27843852700782 1324 720985 YLR208W SEC13
SGTC_2345 9052315 157.45 µM 0.586980761294378 0.291075430364862 no 996 0.278608313858268 1374 6469265
SGTC_2293 7624732 200 µM 0.586607822114626 0.29119774217752 no 997 0.278733564021347 1302 894453
SGTC_1412 3909-8563 178 µM 0.586534310697756 0.291221854340802 no 998 0.2787582557764 1423 23767530
SGTC_1413 3910-0535 34.4 µM 0.586153691558709 0.291346714490119 no 999 0.278886118991324 1410 2876951
SGTC_2474 5321570 43.32 µM 0.585765131501732 0.291474205379086 no 1000 0.279016679265519 1426 2841384
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.584666950844151 0.291834671333637 no 1001 0.279385840193509 1420 6710655
SGTC_3015 9080845 49.47 µM 0.584488394571145 0.291893300126637 no 1002 0.27944588552157 1434 5296973
SGTC_89 0302-0250 142.109 µM 0.5824696048829 0.292556549235879 no 1003 0.280125204592251 1403 4203518 YLR208W SEC13
SGTC_2307 7538926 6.34 µM 0.581833193540563 0.292765779626599 no 1004 0.280339521639705 1372 96582
SGTC_1400 3771-8998 51.5 µM 0.581624347010719 0.292834456397106 no 1005 0.280409869823025 1347 670767
SGTC_447 ml7 120 µM 0.581410313695903 0.292904846540725 no 1006 0.280481973997599 1424 4216 Selective myosin light chain kinase inhibitor.
SGTC_3066 9117245 49.47 µM 0.57949056671224 0.293536553573724 no 1007 0.281129104957635 1450 17176980
SGTC_3326 9140064 16.379 µM 0.578715959020379 0.293791622521037 no 1008 0.281390422904404 1337 1868434
SGTC_3085 9117376 49.47 µM 0.578680716652991 0.293803229845063 no 1009 0.281402314888424 1423 16480349
SGTC_911 3456-4043 236 µM 0.577169670151609 0.294301103183409 no 1010 0.281912421821219 1458 914281
SGTC_470 aa-861 153 µM 0.576461286150715 0.29453464205873 no 1011 0.282151715056499 1326 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_3035 9091303 49.47 µM 0.575953861093905 0.294701981669897 no 1012 0.282323184127167 1387 25237002
SGTC_3259 9138485 49.47 µM 0.575480039949617 0.294858278893817 no 1013 0.282483343015528 1479 17646153
SGTC_1085 doxorubicin 7.67 µM 0.574526391277275 0.295172970421545 no 1014 0.282805823437743 1423 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2737 bleomycin 30.5 nM 0.573856833202303 0.295394008141624 no 1015 0.28303234301062 1385 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2262 9014885 67.46 µM 0.572474557466862 0.295850572337672 no 1016 0.283500258854857 1340 6457424
SGTC_2079 5212404 121 µM 0.569124673707753 0.296958377652105 no 1017 0.284635767501592 1432 758462
SGTC_159 3970-0959 50 µM 0.568726061744223 0.297090324726466 no 1018 0.28477102925922 1439 6615653
SGTC_514 4466-0038 2.65 nM 0.56779761683481 0.297397759058299 no 1019 0.285086199118602 1352 5722064
SGTC_1121 fusaric acid 630.51 nM 0.564777178056876 0.298398915509201 no 1020 0.286112665916358 1374 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2986 9022445 71.43 µM 0.564717103249857 0.29841884348953 no 1021 0.286133099552418 1409 6459286
SGTC_2492 derrusnin 100 µM 0.564279664682095 0.298563968616293 no 1022 0.286281909285091 1325 1715307 Part of coumarin class of compounds.
SGTC_196 k015-0023 18.111 µM 0.564230387586863 0.298580318854146 no 1023 0.286298674881817 1384 5211998
SGTC_216 k038-0035 28.382 µM 0.564018331497483 0.298650684131366 no 1024 0.286370828261835 1341 4444231 YPR107C YTH1
SGTC_455 paf C-16 10 µM 0.562552245811884 0.299137372522963 no 1025 0.28686990884736 1377 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2098 5376439 882.5 nM 0.562248961280831 0.299238097139609 no 1026 0.28697320350481 1481 2844116
SGTC_2174 5790901 200 µM 0.56199010163242 0.299324079863088 no 1027 0.287061381575269 1390 786020
SGTC_2921 7974240 10.71 µM 0.56049726268394 0.299820159199725 no 1028 0.287570153122149 1442 2979074 YDR527W RBA50
SGTC_378 3970-0959 8.33 µM 0.559129268117171 0.300275078577156 no 1029 0.288036750665098 1401 6615653
SGTC_1998 st075797 76.8 µM 0.557024405973857 0.300975648031931 no 1030 0.288755377139417 1391 24208315
SGTC_2052 5265182 7.135 µM 0.5554832386149 0.301489067592974 no 1031 0.289282085855374 1485 1239884
SGTC_14 0354-0009 295 µM 0.555225476635044 0.301574976050456 no 1032 0.289370222539134 1445 1713507
SGTC_1802 st050112 57.9 µM 0.553074653866914 0.302292244033601 no 1033 0.290106145850358 1375 4662563
SGTC_1831 st055328 12 µM 0.552329329581593 0.302540977249836 no 1034 0.290361369727835 1453 1103068
SGTC_3108 9121785 49.47 µM 0.551385268590682 0.302856165461185 no 1035 0.29068479852065 1439 17140271
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.551269139516694 0.302894946959465 no 1036 0.29072459517721 1382 688667
SGTC_535 2293-4129 48.2 µM 0.551160075032098 0.302931371250534 no 1037 0.290761973166291 1466 396118 YIL048W NEO1
SGTC_1739 st037196 92.5 µM 0.550967341976987 0.302995743146397 no 1038 0.290828031087923 1457 612214
SGTC_3265 9137266 49.47 µM 0.550629860218261 0.303108475140389 no 1039 0.290943717521787 1411 17224265
SGTC_1323 1348-1351 11.2 µM 0.549920331833198 0.303345546297145 no 1040 0.291187009095156 1402 6989654
SGTC_3275 9138069 49.47 µM 0.54931719597232 0.303547134188131 no 1041 0.291393894190255 1433 17617007
SGTC_1782 st039423 80.636 µM 0.548670512214334 0.303763343656339 no 1042 0.291615793056723 1365 2068169
SGTC_206 4546-0025 72.014 µM 0.547572053452324 0.304130755036386 no 1043 0.29199289151358 1412 6620745 YIL048W NEO1
SGTC_862 0452-0056 10.2 µM 0.546618980943614 0.30444969811341 no 1044 0.292320263033742 1374 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_1049 3226-0134 66 µM 0.545148505304074 0.304942080496928 no 1045 0.292825692282006 1419 5702385
SGTC_1815 st051655 58.2 µM 0.542303074847457 0.305895863554427 no 1046 0.293804868867646 1400 5984156
SGTC_1125 tnp00248 1.32998 µM 0.540780947612457 0.306406619311373 no 1047 0.2943292882204 1527 24207736
SGTC_1362 1611-0397 101 µM 0.54027699977427 0.30657580396168 no 1048 0.294503008851524 1410 27816
SGTC_2820 7989630 71.43 µM 0.539875303975692 0.306710690234521 no 1049 0.294641515097143 1366 2984098
SGTC_902 1120-0002 2.07 µM 0.536676703384116 0.307785688043064 no 1050 0.295745475450031 1386 3280475
SGTC_839 0122-0028 230 µM 0.533812328241474 0.308749760848319 no 1051 0.296735691728215 1434 759448
SGTC_619 1652-1634 108 µM 0.533109538068752 0.308986503249515 no 1052 0.296978878447805 1425 5400454
SGTC_738 1315-0003 72.4 µM 0.532835070048855 0.309078982299384 no 1053 0.297073877458437 1491 6251474
SGTC_2815 7968870 71.43 µM 0.532526749754164 0.309182881940987 no 1054 0.297180610005858 1415 2977326 YHR190W ERG9
SGTC_1106 tegaserod maleate 11.7 µM 0.532418136286184 0.309219486801568 no 1055 0.297218213366663 1472 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2167 5876490 200 µM 0.532005801811653 0.309358468814374 no 1056 0.297360988589184 1636 686534
SGTC_1999 st074831 12.5 µM 0.531377885814667 0.309570167419085 no 1057 0.297578471383626 1409 17112523
SGTC_2822 7994718 71.43 µM 0.531017982465163 0.30969153545478 no 1058 0.297703158977768 1458 1018011
SGTC_21 0849-0113 22.993 µM 0.531017441834406 0.309691717784042 no 1059 0.297703346295839 1401 1560156
SGTC_1956 st077085 54 µM 0.529553213206795 0.310185704743386 no 1060 0.29821087028903 1412 24208685
SGTC_3038 9091290 49.47 µM 0.527893345705723 0.31074610888241 no 1061 0.29878668175466 1485 25236843
SGTC_3216 9129716 49.47 µM 0.527152283540725 0.310996448088279 no 1062 0.299043920803955 1382 8056934
SGTC_2432 5630864 12.22 µM 0.526270555683501 0.311294419728437 no 1063 0.299350118953559 1412 5714970
SGTC_530 4358-1714 28 µM 0.526093256981693 0.311354351100113 no 1064 0.299411706744853 1485 1564641
SGTC_836 0330-0104 1.35 µM 0.525973397794978 0.311394869319586 no 1065 0.29945334517512 1454 46494820
SGTC_521 r062-0005 13.8 µM 0.524804383485868 0.311790172612829 no 1066 0.29985959198631 1436 2832033
SGTC_1116 jasmonic acid 1.58368 µM 0.52205412860191 0.312721028870965 no 1067 0.300816321791515 1499 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2973 9094665 17.96 µM 0.520674504436653 0.313188429714505 no 1068 0.301296769036669 1572 25237061 YIL048W NEO1
SGTC_312 4092-0653 6.84 µM 0.519977785004279 0.313424584435756 no 1069 0.301539529351361 1501 1148278
SGTC_851 0394-0702 453 µM 0.518866396787286 0.313801450474072 no 1070 0.301926956153715 1498 762646
SGTC_1692 fluoroquinolonic acid 71 µM 0.515642157839824 0.314895872045067 no 1071 0.303052180115458 1468 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2469 5655019 90.81 µM 0.514146645873429 0.315404055219879 no 1072 0.303574733502836 1565 2788239
SGTC_817 1391-0715 46 µM 0.514145509871115 0.315404441372617 no 1073 0.303575130591269 1430 1353946
SGTC_883 0850-0245 24.6 µM 0.513514381446966 0.315619007281316 no 1074 0.303795776725288 1548 6823229 YPR165W RHO1
SGTC_3005 9076496 71.4286 µM 0.513474532284799 0.315632556962681 no 1075 0.303809710623178 1481 21368410
SGTC_2151 5563267 85.4165 µM 0.513344823488564 0.315676662814669 no 1076 0.303855067355882 1462 5310824
SGTC_922 1866-0035 480 µM 0.512615020589908 0.315924872077829 no 1077 0.3041103220242 1517 3156169
SGTC_1450 4112-4260 37.6 µM 0.512349857841808 0.316015075692561 no 1078 0.304203088574053 1508 1633175
SGTC_2176 5809774 33.9695 µM 0.51140768384522 0.316335674985522 no 1079 0.30453280780228 1484 2870539
SGTC_1439 4092-1168 46 µM 0.511393679107107 0.316340441505362 no 1080 0.304537710040338 1486 2886240
SGTC_456 gingerol 170 µM 0.51052281812765 0.316636899405139 no 1081 0.304842616375427 1511 442793 A herb.
SGTC_1442 4112-3290 3 µM 0.509985768115389 0.316819780351054 no 1082 0.305030716229208 1446 704353
SGTC_1398 3558-0053 112 µM 0.506624886929564 0.317965272223781 no 1083 0.306209021461223 1440 4532369
SGTC_848 0368-0089 85.6 µM 0.50610650946955 0.318142106734475 no 1084 0.30639094054844 1452 762535
SGTC_2220 6782180 200 µM 0.505969559465109 0.318188831522572 no 1085 0.30643900967676 1466 833803
SGTC_607 4491-0986 66.8 µM 0.503159464549874 0.319148221395802 no 1086 0.30742608079083 1568 698981 YDR232W HEM1
SGTC_299 1273-0059 1.44 µM 0.501934481826209 0.319566820621034 no 1087 0.307856804444498 1475 2848077
SGTC_457 grayanotoxin iii 135 µM 0.500516600379887 0.320051624074662 no 1088 0.308355685139944 1443 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2625 euphol 100 µM 0.499072208008273 0.320545808310473 no 1089 0.308864257845842 1594 6708538 A triterpene alcohol.
SGTC_504 lovastatin 124 µM 0.498930538939299 0.320594296103688 no 1090 0.308914159498339 1438 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_748 act1.228 77.9 µM 0.498558340118394 0.320721699820564 no 1091 0.309045279983004 1410 4421505 YNR035C ARC35
SGTC_2078 5212016 200 µM 0.498322703447589 0.320802369210358 no 1092 0.309128304095402 1498 1899708
SGTC_2380 9035439 200 µM 0.495502317095031 0.321768574487832 no 1093 0.310122793411018 1565 6462575
SGTC_2823 7987624 58.44 µM 0.495199702547549 0.321872315677002 no 1094 0.31022958028622 1500 2239440
SGTC_1908 st060353 56.5 µM 0.495159107273928 0.321886233453604 no 1095 0.310243906798005 1648 4227716
SGTC_1747 st037496 66.6 µM 0.494239307529297 0.322201646643363 no 1096 0.310568591240582 1474 723305
SGTC_3159 9100096 49.47 µM 0.494197027493485 0.32221614818526 no 1097 0.310583519420199 1414 25236875
SGTC_518 1021-0119 62.6 µM 0.494168301999758 0.322226000837238 no 1098 0.31059366195782 1441 1097762
SGTC_3298 9116858 71.43 µM 0.493348386590083 0.32250727897527 no 1099 0.310883222375051 1561 2506942
SGTC_1862 st057513 3.81 µM 0.493309573571044 0.322520596593326 no 1100 0.310896932443114 1478 5393163
SGTC_2680 butyl paraben 22.24 µM 0.493094264421008 0.322594478130836 no 1101 0.310972991667219 1507 7184 An antifungal and steroid mimetic.
SGTC_2459 5811157 9.22 µM 0.492894085889724 0.322663174007096 no 1102 0.311043713155439 1453 2870684 YBR192W RIM2
SGTC_2661 dactinomycin 12.96 µM 0.492788627667356 0.322699366861138 no 1103 0.311080973516035 1494 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_1185 1319-0113 81.3 µM 0.490829382700509 0.323372077341971 no 1104 0.311773563211464 1536 4672763
SGTC_1130 3454-2858 15.9 µM 0.490592796446331 0.323453348825166 no 1105 0.311857241172253 1467 715628 YIL048W NEO1
SGTC_2829 7992743 58.44 µM 0.489725959364478 0.323751194350957 no 1106 0.312163914893156 1583 16462845
SGTC_2308 7584454 197.62 µM 0.488479949370723 0.324179521595557 no 1107 0.312604962264451 1594 893577
SGTC_1016 4226-1401 38 µM 0.486045009884609 0.325017225779143 no 1108 0.313467626975403 1490 2901613
SGTC_3061 glucosamine 200 µM 0.485750712685589 0.325118534344716 no 1109 0.313571961595605 1524 91431 and experimental redox chemotherapeutic
SGTC_1312 1218-2183 165 µM 0.485684588925374 0.325141298499199 no 1110 0.313595405928296 1504 6744073
SGTC_314 1671-0008 2.74 µM 0.48567749338252 0.325143741291278 no 1111 0.313597921714221 1446 3913060
SGTC_441 propafenone 146 µM 0.484843629015783 0.325430869211261 no 1112 0.313893635870009 1456 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_320 4092-0846 5.34 µM 0.4839589807824 0.325735597050977 no 1113 0.314207490281067 1554 1359356
SGTC_2310 7668677 200 µM 0.482700357945785 0.326169345699186 no 1114 0.314654254529452 1550 2197143
SGTC_2772 vinpocetine 57.06 µM 0.481875957956363 0.32645357932015 no 1115 0.314947033028624 1560 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1839 st053978 48 µM 0.480963069343312 0.326768439330773 no 1116 0.315271373219945 1520 3788398
SGTC_1516 st013856 110 µM 0.480226503647342 0.327022574620154 no 1117 0.315533171479947 1492 5281404 A mutagen and neurotoxin.
SGTC_1267 0828-0272 9.49 µM 0.480055003845659 0.327081758257581 no 1118 0.315594141118058 1617 745334
SGTC_910 3454-3003 490 µM 0.479396370393542 0.327309089445465 no 1119 0.315828337557237 1495 820824
SGTC_2115 tiliquinol 12.7705 µM 0.478640508296354 0.327570058617163 no 1120 0.316097197628814 1532 71208 A bioactive hydroxyquinoline.
SGTC_2803 7707263 71.43 µM 0.475871350149269 0.328526858047666 no 1121 0.317083017098329 1501 2199229
SGTC_928 2764-0428 58.7 µM 0.475278905543628 0.328731705850079 no 1122 0.317294096205859 1554 662578
SGTC_356 1634-0012 32.5 µM 0.473922048108702 0.329201056244395 no 1123 0.317777747991373 1566 735457
SGTC_1101 ebselen 5.29 µM 0.470636155075234 0.330338793827532 no 1124 0.318950292064022 1647 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_273 hydroxyurea 18.1 mM 0.470209611744936 0.33048659944673 no 1125 0.319102633847655 1549 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_932 2857-0803 154 µM 0.470083868885007 0.330530176858825 no 1126 0.319147549283349 1634 674898
SGTC_361 000s-0510 1.45 µM 0.469155867336891 0.330851855848754 no 1127 0.319479114137706 1533 660
SGTC_1468 k284-1086 134 µM 0.467221416112643 0.331522808243199 no 1128 0.320170736441698 1528 15996457
SGTC_1983 st071813 46.9 µM 0.466884023221319 0.331639886338459 no 1129 0.320291428272324 1520 11838595
SGTC_522 1273-0010 11.6 µM 0.464683030478583 0.332404052053171 no 1130 0.321079231183663 1572 5705015
SGTC_2038 4100038 30.985 µM 0.463446415648435 0.332833700174404 no 1131 0.321522207511656 1570 3596803
SGTC_2910 7948405 25.97 µM 0.463126778314309 0.332944790363856 no 1132 0.321636748329846 1620 2971328
SGTC_1966 st070145 16.1 µM 0.461978863965155 0.333343869674812 no 1133 0.322048238788381 1485 3748532
SGTC_2127 5253358 187.912 µM 0.461819662856784 0.333399231807409 no 1134 0.322105324522018 1475 20612
SGTC_899 1083-0020 478 µM 0.461465235693169 0.333522496768155 no 1135 0.322232428750903 1614 767123
SGTC_644 1498-1197 63.3 µM 0.459392179747706 0.334243837203523 no 1136 0.322976281522787 1583 6741615
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.458508997595508 0.334551335461738 no 1137 0.323293399885116 1574 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_475 α-linolenic acid 10 µM 0.458116336221724 0.334688084359524 no 1138 0.323434431460968 1605 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1786 berberine 21.6 µM 0.4569461337937 0.335095750987144 no 1139 0.323854881657794 1490 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1789 tunicamycin 25 nM 0.456844789909278 0.335131065584526 no 1140 0.323891304796988 1508 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1868 st057644 42.7 µM 0.455142369679533 0.335724513758913 no 1141 0.324503408967259 1516 688665
SGTC_3276 9139060 49.47 µM 0.452939539292422 0.336493008607074 no 1142 0.325296139268266 1582 4870619
SGTC_1353 1498-1206 8.11 µM 0.45166104625445 0.33693934634271 no 1143 0.325756592358948 1534 6756808
SGTC_2452 5863136 48.41 µM 0.451086722450659 0.337139924697177 no 1144 0.325963523403462 1509 2184096
SGTC_863 0466-0191 129 µM 0.450315521194901 0.337409333881481 no 1145 0.326241474467083 1614 765160 YPR165W RHO1
SGTC_1928 4'-methoxychalcone 40.3 µM 0.449426138207575 0.337720131839489 no 1146 0.32656213964151 1724 641818
SGTC_1884 5633444 25 µM 0.449271798852476 0.337774077538058 no 1147 0.326617799432491 1575 5724239
SGTC_1574 spiramycin 23.7 µM 0.448449415499463 0.338061578502786 no 1148 0.326914442663546 1489 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2428 5615643 7.78 µM 0.448331057002326 0.338102963801624 no 1149 0.326957144959765 1583 2253075
SGTC_1932 st074806 40.9 µM 0.446409513394941 0.338775125238919 no 1150 0.327650731043813 1633 17251235
SGTC_343 4130-2827 29.8 µM 0.44596410273439 0.338931004582126 no 1151 0.327811588211764 1535 1118244
SGTC_3207 9114163 49.47 µM 0.445680821723605 0.339030158137196 no 1152 0.327913909935756 1734 849233
SGTC_1921 5740136 50 µM 0.444935264168992 0.339291170251642 no 1153 0.328183268691516 1692 1774243
SGTC_60 0986-0278 202 µM 0.444934467712992 0.339291449124048 no 1154 0.328183556486923 1388 3110598
SGTC_2004 4023728 41.89 µM 0.444598642998756 0.339409043180349 no 1155 0.3283049141597 1653 360084 YDR527W RBA50
SGTC_146 3448-8650 53.125 µM 0.444036971506269 0.339605755819016 no 1156 0.328507927043773 1587 2891488 YIL048W NEO1
SGTC_2564 betulinic acid 100 µM 0.443844909224981 0.339673031284877 no 1157 0.328577358455762 1764 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2508 celastrol 40.54 µM 0.443014513431949 0.339963960610243 no 1158 0.328877618506653 1502 122724 Celastrol is a natural product and antioxidant.
SGTC_2300 7976697 71.57 µM 0.442426068890811 0.340170179992853 no 1159 0.329090459103024 1497 2236109
SGTC_2961 9083290 32.55 µM 0.442420437595819 0.340172153701635 no 1160 0.329092496212198 1581 17741490
SGTC_339 3091-4833 71.4 µM 0.442142672125591 0.340269512968339 no 1161 0.329192983587697 1604 3240077
SGTC_831 k061-1017 217 µM 0.44106626024404 0.340646905446572 no 1162 0.329582514268795 1645 1240153
SGTC_3180 9109287 49.47 µM 0.440334511564831 0.340903549356323 no 1163 0.329847424271095 1557 18891271
SGTC_412 gemfibrozil 100 µM 0.440193698404758 0.340952944765521 no 1164 0.329898411701049 1575 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2164 5685496 200 µM 0.437146194705203 0.342022635851689 no 1165 0.331002663819143 1637 759046
SGTC_1142 3253-1408 9.78 µM 0.436506713611942 0.342247258736998 no 1166 0.331234564651416 1596 256655
SGTC_2931 9014674 55.67 µM 0.43591962830983 0.342453526333625 no 1167 0.331447521726066 1506 2996810
SGTC_2584 androsterone 48.74 µM 0.435767198053864 0.342507089139282 no 1168 0.331502822609247 1589 2754130 A steroid.
SGTC_480 am 92016 50 µM 0.435177188423407 0.342714443780311 no 1169 0.331716909571699 1521 2129 K+ channel blocker.
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.434531259581973 0.342941505174554 no 1170 0.331951350042492 1684 23847180
SGTC_2031 5180455 200 µM 0.431761755045772 0.343915702907867 no 1171 0.332957289305559 1545 29949
SGTC_745 0469-0705 296 µM 0.430928671593516 0.344208950594061 no 1172 0.333260117586915 1700 3486736
SGTC_1134 3477-0009 42.5 µM 0.430492975938808 0.344362354001685 no 1173 0.333418537551968 1765 3973534
SGTC_2653 dihydrofissinolide 100 µM 0.429261746363764 0.344795994071244 no 1174 0.333866376083178 1613 6857746
SGTC_1227 3909-8010 46.6 µM 0.428486445194553 0.345069160482511 no 1175 0.334148500032407 1597 15982272
SGTC_2180 6301957 200 µM 0.4278750152197 0.34528464615961 no 1176 0.334371059095849 1639 845462
SGTC_2721 ifenprodil 61.44 µM 0.424798226482368 0.346369755967577 no 1177 0.335491885329824 1669 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1042 0350-0096 82 µM 0.42381050574242 0.346718369512062 no 1178 0.33585200786241 1546 3122515
SGTC_3312 9133330 71.43 µM 0.422884109592602 0.347045456696387 no 1179 0.336189908512197 1667 17617324
SGTC_1210 3013-0140 750 nM 0.420460712547022 0.347901635852425 no 1180 0.337074462038051 1727 905973
SGTC_182 3448-4371 550.524 µM 0.419264947726457 0.348324382332688 no 1181 0.337511255430223 1750 3491403
SGTC_1066 ketoconazole 628 nM 0.418290158688489 0.348669145311534 no 1182 0.3378674920566 1669 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2627 acetyl isogambogic acid 100 µM 0.416289198308271 0.349377235578613 no 1183 0.338599197860199 1527 6857789 A caspase activator and apoptosis inducer.
SGTC_155 k072-0202 43.6 µM 0.415740587031082 0.34957146723322 no 1184 0.33879991916358 1591 5857737
SGTC_59 0330-0160 1.33 µM 0.415439065394552 0.349678235454181 no 1185 0.338910256877418 1656 4293482
SGTC_1648 st011736 69.8 µM 0.41459998609196 0.349975414354381 no 1186 0.339217379184149 1674 2855514
SGTC_2934 9036370 36.88 µM 0.413200817800174 0.350471165781541 no 1187 0.339729744505878 1731 6462800
SGTC_3046 9092212 49.47 µM 0.412100948544558 0.350861048910095 no 1188 0.340132716732287 1629 25236637
SGTC_1844 rapamycin 4 nM 0.411580800298184 0.351045486496725 no 1189 0.34032335330687 1615 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_373 0844-0104 25.9 µM 0.411136668287657 0.351202997526072 no 1190 0.340486161909694 1729 5375804
SGTC_2476 5806916 10.51 µM 0.410613201649116 0.351388677331673 no 1191 0.340678090936527 1659 2870194
SGTC_2411 st077133 39.94 µM 0.410438474694782 0.351450662946453 no 1192 0.3407421637552 1761 1403142 YNL221C POP1
SGTC_2770 toltrazuril 17.5 µM 0.409224268331329 0.351881520223648 no 1193 0.341187543146069 1696 68591 Kills coccidiodes.
SGTC_1977 st070720 65.3 µM 0.406888448519111 0.352710913182722 no 1194 0.342044960236893 1604 682188
SGTC_2075 5212009 200 µM 0.405504520698097 0.353202643156275 no 1195 0.342553348061449 1681 780898
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.404997582260728 0.353382827265541 no 1196 0.342739644064199 1582 803109
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.404890896908469 0.353420751254995 no 1197 0.342778854989595 1688 1377
SGTC_2895 9054447 58.44 µM 0.403926019537678 0.353763807223071 no 1198 0.343133561015428 1629 2697450
SGTC_70 0141-0289 43.283 µM 0.403437418805373 0.353937571405845 no 1199 0.34331323206038 1702 352408
SGTC_2740 felodipine 17.08 µM 0.402289235709668 0.354346026764349 no 1200 0.343735587843057 1728 3333 L-type calcium channel blocker
SGTC_2899 9053889 58.44 µM 0.401314791788335 0.354692807541961 no 1201 0.344094187274504 1709 6470052
SGTC_125 0133-0007 11.75 µM 0.400290767835782 0.35505736244742 no 1202 0.344471183506413 1802 26541
SGTC_725 1497-0963 19 µM 0.399588209418486 0.355307551663674 no 1203 0.344729921050928 1763 3549977
SGTC_1363 1636-0063 10.4 µM 0.399481058670802 0.355345714774809 no 1204 0.34476938881362 1630 6072185
SGTC_331 k048-0133 24.5 µM 0.399205547695905 0.355443848196624 no 1205 0.344870877912379 1601 6813582
SGTC_2685 mycophenolic acid 18.85 µM 0.39828180093224 0.355772944674153 no 1206 0.345211236981765 1683 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2200 6600604 21.907 µM 0.397241752656804 0.356143603711472 no 1207 0.345594597797393 1611 2904777
SGTC_340 k038-0059 454 µM 0.396658068637529 0.356351680339588 no 1208 0.345809812600279 1666 23733424
SGTC_1303 1160-0052 261 µM 0.396380268472966 0.356450727924903 no 1209 0.345912260027443 1649 3562476
SGTC_2605 digitonin 300 nM 0.394655268653442 0.357065980311424 no 1210 0.34654865947884 1726 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2130 NSC 7 2.4545 µM 0.394344677688185 0.357176797750262 no 1211 0.346663291040239 1753 21448
SGTC_508 roscovitine 141 µM 0.394223719100212 0.357219958482742 no 1212 0.346707937708727 1690 160355 A CDKinase inhibitor.
SGTC_1478 0453-0656 35.7 µM 0.39373911547839 0.35739289422192 no 1213 0.346886829671221 1652 5258496
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.392851493156304 0.357709727228301 no 1214 0.347214584934193 1764 6728940
SGTC_832 4083-0019 164 µM 0.392190592810648 0.357945696498892 no 1215 0.347458697177309 1780 1990758
SGTC_229 benomyl 22.8748 µM 0.391096378181157 0.358336496536365 no 1216 0.347862998830746 1617 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_181 1447-1644 8.07 µM 0.386768751541759 0.359883564399483 no 1217 0.349463706469984 1746 534600
SGTC_3119 9125183 49.47 µM 0.386621753528931 0.359936154697231 no 1218 0.349518125500883 1682 22695334
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.386510101993026 0.359976101141855 no 1219 0.349559461244672 1630 5106787 A p450 inhibitor.
SGTC_1461 k072-0203 53.8 µM 0.386439254581117 0.360001449568502 no 1220 0.349585691369804 1598 5418714
SGTC_474 dl-dihydrosphingosine 5 µM 0.385349300287377 0.36039150078829 no 1221 0.349989320018956 1706 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1900 st060200 72.8 µM 0.384843560233629 0.360572534394883 no 1222 0.350176661796662 1626 688945
SGTC_297 0986-0032 24 µM 0.383436052820529 0.361076527100972 no 1223 0.350698237969055 1638 2847425
SGTC_1718 roemerine 11.9335 µM 0.382972752452124 0.361242476035407 no 1224 0.350869983556607 1632 235224 An aporphine alkaloid with mutagenic activity.
SGTC_527 4476-4215 268 µM 0.382380094576669 0.361454797427632 no 1225 0.351089726434441 1666 4418754
SGTC_594 1487-1584 10.8 µM 0.381449713943268 0.361788195028838 no 1226 0.351434788991217 1597 5013332
SGTC_2830 7992007 71.43 µM 0.378777557054277 0.362746332811455 no 1227 0.352426527302319 1614 1952075
SGTC_1738 st035555 74 µM 0.377378595452448 0.363248292687215 no 1228 0.352946135680239 1668 5331140
SGTC_2470 5664817 21.68 µM 0.376016987436619 0.363737075410489 no 1229 0.353452133536346 1666 2859561
SGTC_268 camptothecin 39.6153 µM 0.375904278406961 0.363777545044253 no 1230 0.353494029848457 1666 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2084 5306078 60.6385 µM 0.374545718081309 0.364265473130368 no 1231 0.353999174756645 1713 679340
SGTC_1036 k216-0215 33.5 µM 0.37382367929616 0.364524883581569 no 1232 0.354267750563898 1627 622330
SGTC_2827 7993847 71.43 µM 0.371394263131649 0.365398167001455 no 1233 0.355171948939408 1691 2985692
SGTC_3330 9141424 71.43 µM 0.370632114777168 0.365672274680703 no 1234 0.355455779453994 1770 27261020
SGTC_471 1-acyl-paf 4 µM 0.369494828437824 0.366081428769743 no 1235 0.355879463597649 1611 16759367
SGTC_1359 1582-0056 520 nM 0.369241869573874 0.366172454855317 no 1236 0.355973725005602 1713 3661189
SGTC_2629 bisabolol 100 µM 0.368408940953344 0.366472233599057 no 1237 0.356284165829792 1745 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3305 9127027 53.8275 µM 0.366997881142486 0.366980273003628 no 1238 0.356810299252411 1683 41905295
SGTC_2714 st079313 56.9 µM 0.366867202021657 0.367027334650651 no 1239 0.356859038595985 1670 2939799
SGTC_1430 4049-0248 69.1 µM 0.366595370458484 0.367125236116796 no 1240 0.356960430999002 1767 22774488
SGTC_1111 tnp00062 510.699 nM 0.366517996848588 0.367153104180585 no 1241 0.356989292983978 1792 676306
SGTC_1909 st060837 51.5 µM 0.363453645846171 0.368257369124459 no 1242 0.35813301698386 1649 678937
SGTC_2955 9076254 12.21 µM 0.362991705221628 0.368423928055784 no 1243 0.358305540312805 1812 16459619
SGTC_2208 7283366 200 µM 0.362904370229498 0.36845542064714 no 1244 0.358338161012154 1779 898663
SGTC_2248 tofa 1.1 µM 0.359382517496313 0.369726118534688 no 1245 0.359654475687944 1709 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_54 0159-0055 9 µM 0.355465754425021 0.371140973726537 no 1246 0.3611203479534 1803 3319099
SGTC_1471 k673-0312 37 µM 0.354246388223925 0.37158180305383 no 1247 0.361577120927199 1734 24099884
SGTC_1637 st007924 17.4 µM 0.353617819802616 0.371809111044116 no 1248 0.361812658953715 1667 683336
SGTC_655 k060-0012 42 µM 0.351843080786967 0.372451147518467 no 1249 0.362477973961401 1679 5994525
SGTC_612 0302-0167 22.4 µM 0.350161617505192 0.373059767418313 no 1250 0.363108705131134 1796 235821
SGTC_1435 4092-0789 56.7 µM 0.348752136204528 0.373570185387665 no 1251 0.36363769981561 1792 2248285
SGTC_906 1165-0455 526 µM 0.348593244364475 0.373627739103702 no 1252 0.363697350096823 1651 3252859
SGTC_3308 9128332 17.569 µM 0.347066576296156 0.374180871447034 no 1253 0.364270651429637 1832 17332805 YDL196W YDL196W
SGTC_2808 7946468 45.46 µM 0.346900637091531 0.374241009082459 no 1254 0.364332984003133 1745 2970879
SGTC_510 ag-490 170 µM 0.3468234997815 0.374268965274885 no 1255 0.364361960698539 1803 5328779
SGTC_116 0155-0182 31.788 µM 0.345585966010292 0.374717563977893 no 1256 0.36482694718139 1698 771486
SGTC_1670 st016595 4.04 µM 0.344845229007295 0.374986157955578 no 1257 0.365105364235132 1744 597879
SGTC_3016 9080866 49.47 µM 0.344576894083293 0.375083472161251 no 1258 0.365206239476857 1659 17066299
SGTC_1761 st044296 37 µM 0.343151963576576 0.375600369826078 no 1259 0.365742070225521 1664 1826700
SGTC_382 3229-0966 23.2 µM 0.342977634080672 0.37566362370899 no 1260 0.365807643086169 1799 5722370
SGTC_407 eburnamonine 100 µM 0.342862293117495 0.375705475972764 no 1261 0.365851029964574 1667 3195
SGTC_1520 flindersine 88 µM 0.342556661910657 0.375816383434335 no 1262 0.365966005082497 1858 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2849 9019321 12.99 µM 0.342406921514928 0.375870724979068 no 1263 0.366022340176301 1736 16489627
SGTC_679 0422-0091 41.4 µM 0.340300777471439 0.376635315642405 no 1264 0.366815015860961 1648 627384 YHR062C RPP1
SGTC_3199 9111318 49.47 µM 0.33900682221579 0.3771052988135 no 1265 0.367302295394545 1795 8548020
SGTC_633 0437-0093 97.7 µM 0.338788791857514 0.377184508525061 no 1266 0.367384422647894 1698 2831118
SGTC_2760 etidronate 98.04 µM 0.338458393704124 0.377304550935132 no 1267 0.367508887945952 1677 3305 A chelator and antioxidant.
SGTC_894 0960-0238 55.9 µM 0.337837783638973 0.377530067071839 no 1268 0.36774271747884 1768 6741907 YDL195W SEC31
SGTC_1605 st000082 49.1 µM 0.337395199689589 0.37769091792284 no 1269 0.367909501414187 1782 1114022
SGTC_743 1275-0778 158 µM 0.336203532239646 0.378124117912435 no 1270 0.368358694725097 1822 2849257 YMR203W TOM40
SGTC_964 1287-0107 19.4 µM 0.333083408959939 0.379259083074741 no 1271 0.369535661376299 1826 51516812 YPR165W RHO1
SGTC_658 3253-0951 102 µM 0.332800714986916 0.379361966449213 no 1272 0.369642359246838 1749 1184878
SGTC_1334 1486-0610 236 µM 0.331875227230049 0.379698847315936 no 1273 0.369991738520027 1766 3742339
SGTC_2968 9090663 33.37 µM 0.330760973567643 0.380104560806626 no 1274 0.370412520853612 1730 25236811
SGTC_1010 4112-3296 15.2 µM 0.33067298891925 0.380136602728898 no 1275 0.370445753640811 1888 704384
SGTC_2194 5927483 104.545 µM 0.329955830078337 0.380397805633327 no 1276 0.370716668607247 1771 760979
SGTC_3237 9133362 49.47 µM 0.328607419411359 0.38088907007604 no 1277 0.371226219685429 1782 43845137
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.327731199316245 0.381208405046316 no 1278 0.371557455714479 1760 165521
SGTC_2341 7987486 176.74 µM 0.326530263597419 0.381646212746718 no 1279 0.37201159795451 1882 1258686
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.326148916618393 0.381785266587205 no 1280 0.372155844270231 1716 442882
SGTC_1808 st050063 61.5 µM 0.326123495736119 0.381794536565471 no 1281 0.372165460478415 1824 4011993
SGTC_3193 9111931 49.47 µM 0.325829191108463 0.381901862617099 no 1282 0.372276795799113 1739 17087244
SGTC_692 k241-0027 77.8 µM 0.325532147149095 0.38201019684404 no 1283 0.372389178234177 1823 3600480
SGTC_1947 st076332 61.6 µM 0.324838991450359 0.382263032004885 no 1284 0.372651466268911 1849 24208416
SGTC_955 1216-0110 33 µM 0.324629595218054 0.382339421160141 no 1285 0.372730712796032 1674 3619719
SGTC_2952 9073731 13.78 µM 0.320864843237329 0.383713606632709 no 1286 0.374156408685639 1697 16457353
SGTC_2399 5884133 200 µM 0.32004434130507 0.384013295823104 no 1287 0.374467358687731 1694 722445
SGTC_994 3910-0338 138 µM 0.31957581374771 0.384184457131713 no 1288 0.374644955722819 1822 3479481
SGTC_2762 leflunomide 42.06 µM 0.319294622308033 0.384287192129646 no 1289 0.374751555108827 1759 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2521 angolensin 13.4 µM 0.318100557978909 0.384723541249955 no 1290 0.375204330196021 1791 821428 A flavenoid.
SGTC_2561 acetosyringone 100 µM 0.317273069152666 0.385026017732938 no 1291 0.37551820512447 1729 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.314789290841521 0.385934346269532 no 1292 0.376460821676592 1842 688662
SGTC_2373 9071805 200 µM 0.314694697578572 0.385968951837303 no 1293 0.376496735291262 1919 10149009
SGTC_2047 4141938 200 µM 0.312511658206099 0.386767836581258 no 1294 0.377325852228601 1766 3807862
SGTC_1682 st012968 530 nM 0.311778260232418 0.387036331963038 no 1295 0.377604523459054 1690 24207270
SGTC_1514 1189-1591 158 µM 0.310630780862887 0.387456530053002 no 1296 0.378040662133569 1839 767698 YMR146C TIF34
SGTC_2687 chenodiol 100 µM 0.310102002407514 0.387650209060554 no 1297 0.378241694787646 1786 5702181 A cholesterol synthesis inhibitor.
SGTC_2435 5706476 10.6 µM 0.309489333045636 0.3878746502804 no 1298 0.378474662574036 1918 5725375
SGTC_2743 auranofin 4.32 µM 0.309484195672592 0.38787653242997 no 1299 0.378476616249215 1821 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_1624 st003710 6.25 µM 0.309213626018902 0.387975663186637 no 1300 0.378579514706941 1874 24207033
SGTC_2041 5107442 45.335 µM 0.308977081536753 0.388062333851947 no 1301 0.378669480342587 1863 793005
SGTC_3078 9116413 49.47 µM 0.308445193583605 0.388257239681378 no 1302 0.378871798809679 1727 17177322
SGTC_1933 st074711 15.9 µM 0.304842792867365 0.389578047375267 no 1303 0.380242943863498 1759 17250958
SGTC_1314 1222-0010 41.1 µM 0.303876895805196 0.389932407814957 no 1304 0.38061084021381 1800 3526027
SGTC_2032 5185112 25.99 µM 0.303717221889753 0.389990996500217 no 1305 0.380671668130914 1822 5718189
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.303644995083714 0.390017499293063 no 1306 0.380699183964633 1726 2333 A French combination drug.
SGTC_1952 st077036 64.1 µM 0.301792515344018 0.39069741974335 no 1307 0.381405118449046 1813 2937007
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.301707253368535 0.39072872173137 no 1308 0.38143761921157 1744 4174840
SGTC_1351 1496-0003 46.5 µM 0.301218317880883 0.390908236901924 no 1309 0.381624011234494 1864 3891978
SGTC_1088 bifonazole 369 nM 0.300166152173352 0.391294623735828 no 1310 0.382025210976204 1781 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_2028 5153890 36.43 µM 0.299580934311576 0.391509579765293 no 1311 0.382248414400906 1758 2830968 YPR165W RHO1
SGTC_624 k048-0052 28 µM 0.298911832193245 0.391755387865993 no 1312 0.38250365941989 1785 6835531
SGTC_1242 0402-0103 60.1 µM 0.297403099733992 0.392309809492501 no 1313 0.383079388722486 1770 432868
SGTC_1954 st077032 68.9 µM 0.297049322966233 0.392439845339121 no 1314 0.383214426674688 1688 698907
SGTC_3283 9109332 35.8195 µM 0.2957280434515 0.392925607107171 no 1315 0.38371888949961 1758 17027281
SGTC_3262 9137218 49.47 µM 0.294262147804589 0.393464731427751 no 1316 0.384278797244871 1806 17650664
SGTC_1530 rhein 70.4 µM 0.29370254474833 0.393670595123177 no 1317 0.384492604802965 1827 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2418 pentamidine 31.67 µM 0.291268675055494 0.394566298779106 no 1318 0.38542292149847 1828 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_62 0180-0423 3.232 µM 0.291268484099647 0.394566369075906 no 1319 0.385422994514939 1852 30102 YGL099W LSG1
SGTC_3149 9097855 49.47 µM 0.291191303530386 0.394594781930523 no 1320 0.385452506656968 1923 25236625 YMR079W SEC14
SGTC_1905 st060207 84.5 µM 0.290376776805886 0.394894671732838 no 1321 0.385764004059905 1789 1948547
SGTC_2488 5268135 45.7 µM 0.290153916134435 0.394976734709563 no 1322 0.385849244951221 1873 1270356 YLR208W SEC13
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.287565684466325 0.395930127907999 no 1323 0.386839607796867 1743 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_2097 5376186 200 µM 0.286241060409527 0.39641830376956 no 1324 0.387346748555038 1902 742755
SGTC_1805 st050013 60.3 µM 0.285139525224264 0.396824386384243 no 1325 0.387768624818897 1881 4037144
SGTC_2133 5320837 200 µM 0.284710886483421 0.396982434976606 no 1326 0.387932824744105 1886 2841355
SGTC_1235 benzylparaben 21.5 µM 0.284094640188659 0.397209688272809 no 1327 0.388168927165333 1827 7180
SGTC_1062 mesoridazine 14.2 µM 0.283732671315494 0.397343187898367 no 1328 0.388307627564081 1805 4078 A neuroleptic.
SGTC_773 4358-1457 44.6 µM 0.28362202872612 0.397383996968734 no 1329 0.388350026791362 1962 1186886
SGTC_279 1273-0055 2.93 µM 0.28354069046194 0.3974139982389 no 1330 0.388381197188437 1932 2847562
SGTC_1667 st014849 34.6 µM 0.282632328794797 0.397749084742063 no 1331 0.388729347759036 1843 5348460
SGTC_569 4130-2812 160 µM 0.282169905278697 0.397919697643683 no 1332 0.388906616596468 1938 743552
SGTC_1687 st020778 55.3625 µM 0.280159084761377 0.398661824090479 no 1333 0.389677727888151 1834 4259299
SGTC_1518 st038567 90.8 µM 0.279869086700695 0.39876888296193 no 1334 0.389788972529821 1807 77966
SGTC_2095 5432005 200 µM 0.279151755343192 0.399033733598426 no 1335 0.390064183037554 1794 783734
SGTC_715 0868-0130 184 µM 0.278994299647934 0.399091875079483 no 1336 0.390124599686227 1968 2876258
SGTC_1616 st002734 56.1 µM 0.278847129520202 0.399146220575835 no 1337 0.390181072103695 1851 4026101
SGTC_699 0375-0592 111 µM 0.277399348347894 0.399680946610827 no 1338 0.390736740971664 1982 762578
SGTC_2145 5634607 200 µM 0.275945998606011 0.400217918656156 no 1339 0.391294771593822 1758 308662
SGTC_908 3448-7491 47.7 µM 0.275903172864405 0.400233744435717 no 1340 0.391311218438393 1771 1203031
SGTC_617 3770-0098 35 µM 0.275325020934823 0.400447410116594 no 1341 0.391533271546019 1827 5962639
SGTC_142 0335-0849 62.6745 µM 0.274534347074525 0.400739665044575 no 1342 0.391837006010235 1832 3889043 YPR107C YTH1
SGTC_2324 6149169 200 µM 0.273161514513927 0.40124723384589 no 1343 0.392364531136209 1906 2888231
SGTC_1886 st057356 49.9 µM 0.272530778727944 0.401480487786048 no 1344 0.392606964284144 1761 24207747
SGTC_1496 4469-0713 57.4 µM 0.272154322861116 0.401619722585357 no 1345 0.392751680841085 1938 746691
SGTC_779 1360-0071 233 µM 0.271777742877694 0.401759015786657 no 1346 0.392896459945622 1971 7566
SGTC_1234 0326-0494 15.5 µM 0.271449628531969 0.401880392205314 no 1347 0.393022618139718 1912 1547813
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.268647246971626 0.402917436734005 no 1348 0.394100575262593 1905 66535 A nucleotide analog.
SGTC_2477 5967686 25.23 µM 0.268482635612552 0.402978373850919 no 1349 0.394163919579794 1785 776118
SGTC_379 3970-0972 5.9 µM 0.267354452209024 0.403396076931107 no 1350 0.394598132604973 1851 2898042 YBL034C STU1
SGTC_2994 9053520 71.4286 µM 0.26718626449205 0.403458356868866 no 1351 0.394662875596906 1937 4647384
SGTC_554 4483-2211 187 µM 0.264621966380219 0.404408219211896 no 1352 0.395650348239241 1847 747107
SGTC_2926 9010726 65.15 µM 0.262092822115987 0.405345612202322 no 1353 0.396624940265896 1783 2994293
SGTC_747 3448-8087 38.7 µM 0.261766060266287 0.405466761784625 no 1354 0.396750903436037 1807 5168703
SGTC_2528 xanthyletin 44.79 µM 0.259821101099624 0.406188058046973 no 1355 0.397500886733222 1810 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_822 1487-0950 154 µM 0.259682215975098 0.406239576390617 no 1356 0.397554455873071 1969 1958375
SGTC_2553 4-methylesculetin 85.09 µM 0.258802118140263 0.406566079456282 no 1357 0.39789396175202 1791 5319502
SGTC_539 4859-0462 2.54 µM 0.258739969609204 0.406589138085455 no 1358 0.397917939048972 1987 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2092 5303694 80.6725 µM 0.258330512698292 0.40674106473404 no 1359 0.398075919752961 1811 1963699
SGTC_2922 7999257 32.47 µM 0.257258025588503 0.407139071431554 no 1360 0.398489796456255 1845 2988377
SGTC_1169 aniline yellow 25.8 µM 0.256635672324974 0.407370074634667 no 1361 0.398730017253622 1908 6051 A DNA damaging agent.
SGTC_3006 9075424 71.4286 µM 0.256442049935788 0.407441949382531 no 1362 0.398804760972958 1802 7465181
SGTC_1273 0849-0096 14.1 µM 0.256385886981766 0.407462798268273 no 1363 0.398826442156435 1816 5286025
SGTC_2942 9052777 62.25 µM 0.255185014380929 0.40790865040755 no 1364 0.399290102400378 1848 6469503
SGTC_163 TUB2.036 7.546 µM 0.255053084646037 0.407957639700637 no 1365 0.399341049512164 1953 15992207 YJR013W GPI14
SGTC_126 0417-1624 672.48 µM 0.254182861448072 0.408280814539837 no 1366 0.39967714523518 2000 41912 YDL195W SEC31
SGTC_337 1315-0038 354 µM 0.253760639271546 0.408437637708539 no 1367 0.399840241775112 1858 1626437
SGTC_453 enantio-paf c16 10 µM 0.253256678075732 0.408624839852098 no 1368 0.400034935446916 1897 13871343 A lipid and platelet activating factor
SGTC_1958 st076513 41.9 µM 0.251101108401854 0.409425785650442 no 1369 0.400867969487049 1846 732122 YGL099W LSG1
SGTC_574 1315-0397 40 µM 0.250047402292823 0.409817449447013 no 1370 0.401275345470389 1899 6794277
SGTC_2698 st077697 67.5 µM 0.247140541021894 0.410898398683631 no 1371 0.402399729721111 1780 3154499
SGTC_1152 3909-8331 15.9 µM 0.247029612234861 0.410939662269473 no 1372 0.402442653432485 1858 16001939
SGTC_2699 st077704 54.6 µM 0.246230347031122 0.411237004175591 no 1373 0.402751962525713 1870 645852
SGTC_802 4112-3352 742 µM 0.246143011303338 0.411269497826489 no 1374 0.402785764430586 1967 704594
SGTC_1199 1638-0010 4.46 µM 0.245742262058152 0.411418606189741 no 1375 0.402940877367713 1822 3111136
SGTC_1987 st072290 61.9 µM 0.245066664960496 0.411670007243036 no 1376 0.403202406756482 1871 54697379
SGTC_2111 5486399 200 µM 0.244096697632871 0.41203101180088 no 1377 0.403577965056403 1845 689674
SGTC_952 1185-0122 232 µM 0.243905586425821 0.412102148777175 no 1378 0.403651971242172 1878 678600
SGTC_992 3909-8734 162 µM 0.242699354717864 0.41255120876104 no 1379 0.404119153685267 1834 4288319
SGTC_424 splitomicin 100 mM 0.242131993289926 0.412762467601717 no 1380 0.40433894429394 1788 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1068 loratadine 26.9 µM 0.241744182542166 0.412906884716843 no 1381 0.404489195995592 1842 3957 A H1 histamine antagonist.
SGTC_924 2046-0044 21.3 µM 0.24094702518575 0.413203775699833 no 1382 0.404798087373353 1853 3623589
SGTC_3242 9133940 49.47 µM 0.240817630459602 0.413251971785235 no 1383 0.404848232279818 1939 17248444
SGTC_2449 5812982 45.77 µM 0.239751488817278 0.413649130816507 no 1384 0.405261458237339 1912 776185
SGTC_3086 9117350 49.47 µM 0.238705915602625 0.414038713517311 no 1385 0.405666814678895 1894 2679265
SGTC_17 0960-0276 49.807 µM 0.236301255520318 0.414935015189665 no 1386 0.406599456379296 1927 6821114
SGTC_2533 agelasine 13.65 µM 0.235726453221761 0.415149330064739 no 1387 0.406822470777909 2037 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_1707 st032323 6.317 µM 0.234459801911581 0.415621689692695 no 1388 0.407314018459737 1920 3132057 YMR211W DML1
SGTC_2027 5150920 200 µM 0.23403173979631 0.415781350228833 no 1389 0.407480168997795 1966 786715
SGTC_2734 clemastine 41.6 µM 0.231977633849297 0.416547692896659 no 1390 0.408277692798594 1952 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1629 st005085 44.9 µM 0.229827646704554 0.417350146605556 no 1391 0.409112850367007 1822 24207091
SGTC_2923 7992654 58.14 µM 0.228383698534711 0.41788927430337 no 1392 0.409673980646159 1883 2985126
SGTC_3011 9081274 71.4286 µM 0.228115377399917 0.417989474544371 no 1393 0.40977827289732 1874 6625322
SGTC_3094 9117742 49.47 µM 0.226703687138365 0.418516735255846 no 1394 0.410327079920051 2002 17149698
SGTC_1723 st034307 2.5525 µM 0.226669900690722 0.418529356157997 no 1395 0.41034021685573 1876 867466
SGTC_1432 4049-0298 68.4 µM 0.225648289325808 0.418911017866797 no 1396 0.410737489929183 2031 741646
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.225460985891887 0.418981000465764 no 1397 0.410810336390841 2071 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2396 5342950 42.78 µM 0.225355656330621 0.419020356110547 no 1398 0.410851302746013 1885 1886677
SGTC_2183 6420625 130.508 µM 0.223374291550302 0.419760829602148 no 1399 0.411622105615999 1938 2897619
SGTC_303 1348-1668 34.2 µM 0.223320785311239 0.419780829848048 no 1400 0.4116429256911 1938 5380509
SGTC_2054 5233173 129 µM 0.222920503068489 0.419930459030449 no 1401 0.411798689366085 1931 6889
SGTC_1291 0993-0025 5.79 µM 0.222257777681494 0.420178217309785 no 1402 0.412056609297521 1997 4353356
SGTC_35 0133-0054 64.071 µM 0.221576545146608 0.42043292741196 no 1403 0.412321771452367 1834 99677
SGTC_951 1171-0579 82.7 µM 0.221548981301269 0.420443234124863 no 1404 0.412332501214632 1915 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2738 aclarubicin 5.55 µM 0.220706451698014 0.42075830029456 no 1405 0.412660503804458 1984 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1893 st059353 36.1 µM 0.218305057496576 0.421656585885637 no 1406 0.413595717088807 1882 3112488
SGTC_184 1494-0393 24.714 µM 0.217001143903645 0.422144509851286 no 1407 0.414103726737246 1850 3090647
SGTC_1380 2291-0730 164 µM 0.215618373114535 0.422662072714713 no 1408 0.414642616494728 1864 2999191
SGTC_1669 st015249 58.4 µM 0.215615170502911 0.422663271588496 no 1409 0.41464386479492 2073 722793
SGTC_209 4077-0173 175.592 µM 0.215258559660682 0.422796770676741 no 1410 0.414782868425177 1953 15993494
SGTC_985 1493-0307 8.71 µM 0.21400201689348 0.423267234438079 no 1411 0.415272742181078 2051 3278274
SGTC_1132 3456-3614 2.5 µM 0.213808545204646 0.423339682155404 no 1412 0.415348180467341 2064 3125502
SGTC_2825 7998094 58.44 µM 0.213647907389321 0.423399836817655 no 1413 0.41541081857397 1940 2987815
SGTC_1495 4469-0029 237 µM 0.213053607325002 0.423622402166333 no 1414 0.415642574906873 1903 793680
SGTC_750 4073-0104 132 µM 0.212310974120107 0.423900552513911 no 1415 0.415932217238212 2012 22330957
SGTC_730 1436-0052 41.2 µM 0.211865388756339 0.424067462969589 no 1416 0.416106026691393 1982 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_3096 9117468 49.47 µM 0.21028016830081 0.42466137606954 no 1417 0.416724506331515 2025 41316311
SGTC_2142 5622915 118.518 µM 0.209786982093527 0.424846186428117 no 1418 0.41691696688406 1917 5322196
SGTC_2366 9070441 60.58 µM 0.209779142774217 0.424849124168926 no 1419 0.416920026254047 1905 6837235
SGTC_3292 9120825 59.784 µM 0.209680425972413 0.424886118092181 no 1420 0.416958551868794 2083 24824900
SGTC_723 4182-0001 115 µM 0.208714689662854 0.425248060677649 no 1421 0.417335485997029 1902 744821 YLR208W SEC13
SGTC_2800 7887935 81.82 µM 0.207611348169997 0.425661652598335 no 1422 0.417766221436484 1948 2961002
SGTC_3026 9090633 49.47 µM 0.207347220093957 0.425760674204445 no 1423 0.417869349521485 1916 25236842
SGTC_3291 9121177 71.43 µM 0.205957643935625 0.426281703223524 no 1424 0.418411998592804 1906 17015612
SGTC_768 0384-0033 77.3 µM 0.205491355124602 0.426456569592883 no 1425 0.418594125799634 1864 3965305 YMR134W ERG29
SGTC_1645 Cervolide 78 µM 0.20346188536729 0.42721782382618 no 1426 0.419387016826107 1934 23173 A fragrance.
SGTC_1759 st043059 70 µM 0.201877100087584 0.427812465542807 no 1427 0.42000640248356 1876 669426
SGTC_2486 5283202 22.39 µM 0.201674055779906 0.427888663526434 no 1428 0.420085773160571 1867 1377751
SGTC_613 3914-0030 117 µM 0.201631844040799 0.42790450498499 no 1429 0.420102274274193 1986 1145395
SGTC_275 trichlorophene 5.69 µM 0.201148700224838 0.428085830180807 no 1430 0.420291151423784 1961 62616
SGTC_3344 9148862 3.898 µM 0.20045436756141 0.428346441713657 no 1431 0.420562621524569 2026 4905352
SGTC_573 3702-0553 84.7 µM 0.199648852505541 0.428648823712699 no 1432 0.420877609042139 1941 1222756
SGTC_445 e6 berbamine 66 µM 0.199595296977956 0.42866892938945 no 1433 0.420898553121424 1954 6610268 A calcium/calmodulin antagonist.
SGTC_1208 2323-2347 50.3 µM 0.199372409132941 0.428752607351835 no 1434 0.420985720770809 2092 5412760
SGTC_459 nigericin 15.3 µM 0.198934278092649 0.428917102605843 no 1435 0.421157077664022 1972 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_874 0599-0792 117 µM 0.198505417047457 0.429078129420632 no 1436 0.421324823446362 2093 765305
SGTC_2776 terbinafine 19.92 µM 0.197851479582405 0.429323689629853 no 1437 0.421580633663101 2049 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2247 cerulenin 830 nM 0.196941214958666 0.429665548825657 no 1438 0.421936770178374 2041 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_751 0833-0568 350 µM 0.196717343596929 0.429749634098089 no 1439 0.422024368530913 1959 6954252
SGTC_463 ikarugamyin 104 µM 0.196682453568881 0.429762738953349 no 1440 0.422038020955084 2050 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2560 caryophyllene 100 µM 0.196551943637593 0.429811759770793 no 1441 0.422089090157875 2020 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_677 0929-0063 136 µM 0.194578918361684 0.430552978935733 no 1442 0.422861304154056 2035 1539583
SGTC_2218 6965428 192.983 µM 0.194535098487698 0.430569443818933 no 1443 0.422878458005295 2038 675684
SGTC_400 oxethazaine 37.5 µM 0.194417600017824 0.430613593299707 no 1444 0.422924455008754 1956 4621 A local anesthetic.
SGTC_996 3970-0799 1.8 µM 0.193558911091094 0.430936267797923 no 1445 0.423260636927333 2063 6615648 YGL040C HEM2
SGTC_371 0195-0006 7.36 µM 0.19340066215448 0.430995738952928 no 1446 0.423322598450184 1926 3928593
SGTC_1313 1220-0047 237 µM 0.192826106348662 0.43121167454194 no 1447 0.423547578626847 2003 3528706
SGTC_990 3985-0011 41.3 µM 0.191803540774027 0.43159603668427 no 1448 0.423948048662631 1974 5399565 YGL099W LSG1
SGTC_2137 5261020 140 µM 0.191795280377387 0.431599141867951 no 1449 0.423951284023799 1961 763655
SGTC_711 k292-0785 179 µM 0.190921881175595 0.43192748707604 no 1450 0.424293398398498 2004 4146315
SGTC_735 3076-0345 636 µM 0.190339217842602 0.432146559370985 no 1451 0.424521661974437 2052 2888990
SGTC_637 1181-0519 7.26 µM 0.189980414574506 0.43228147416946 no 1452 0.424662238966138 2014 6252091 YGR060W ERG25
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.189058354309346 0.432628217271199 no 1453 0.425023540621216 2111 6708630 An antioxidant.
SGTC_170 4197-0004 226 µM 0.188382493463538 0.432882409427606 no 1454 0.425288411101987 1996 218692
SGTC_1202 1988-0068 29.6 µM 0.186681415322951 0.433522309860363 no 1455 0.425955214177275 1891 2850480
SGTC_2233 sulbentine 40.3845 µM 0.185579144790815 0.433937047939575 no 1456 0.426387404748856 2032 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_218 alverine citrate 93.75 µM 0.185569692301878 0.433940604829132 no 1457 0.426391111369636 2068 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1029 k015-0030 64.7 µM 0.184493408470723 0.434345636002972 no 1458 0.426813198841731 1995 2208316
SGTC_1846 st056244 14.8 µM 0.183640122328067 0.434666796855985 no 1459 0.42714789264579 2004 5393182
SGTC_2860 9025725 38.96 µM 0.181920334974893 0.435314223276598 no 1460 0.42782262288945 1880 40546248
SGTC_294 k038-0071 157 µM 0.180781225155859 0.435743145021707 no 1461 0.428269650221225 1975 24152826
SGTC_468 gf-109203x 121 µM 0.180260040336164 0.435939417800909 no 1462 0.428474212470289 2091 2396 A protein kinase C inhibitor.
SGTC_3297 9117502 71.43 µM 0.179932894850776 0.436062625449351 no 1463 0.428602625141915 2125 7453720
SGTC_1127 asiatic acid 681.4 nM 0.178955094155662 0.436430916056857 no 1464 0.428986481039595 1886 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1420 4'-methoxyflavone 42 µM 0.178198591302774 0.43671589221829 no 1465 0.429283507997999 2091 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_1615 st002656 86.5 µM 0.177270458819272 0.437065566464638 no 1466 0.429647976865517 2109 1584458
SGTC_756 0508-1999 28.3 µM 0.177074608004624 0.43713935962121 no 1467 0.42972489330504 1885 6753853
SGTC_1836 st055642 81 µM 0.176124276143877 0.43749745902753 no 1468 0.430098154712908 1899 8571
SGTC_859 0439-0102 54.6 µM 0.176117980854375 0.437499831358787 no 1469 0.430100627519547 2124 610143
SGTC_570 0987-0065 62.6 µM 0.175581536589323 0.437701994484053 no 1470 0.430311354329881 2111 3104428
SGTC_2880 9042983 58.44 µM 0.173024594954411 0.438665820108105 no 1471 0.431316047602673 1992 6464714
SGTC_891 0929-0073 133 µM 0.172273747150492 0.438948917580326 no 1472 0.431611161256455 2066 5603632
SGTC_2213 7173844 200 µM 0.171393909562598 0.439280688718395 no 1473 0.431957021694155 2026 892728
SGTC_764 1951-2361 146 µM 0.171256996236763 0.439332320144783 no 1474 0.432010846440362 1911 5438930
SGTC_2340 7987427 183.45 µM 0.170630931768785 0.439568428645705 no 1475 0.432256987277627 2022 2239331
SGTC_2073 5212005 126 µM 0.168917257524615 0.440214818538314 no 1476 0.432930862356987 2156 691789
SGTC_961 1252-1571 372 µM 0.168388604327163 0.440414256291822 no 1477 0.433138786264898 2105 6813498
SGTC_593 1203-0218 61.7 µM 0.167928921434792 0.440587686852006 no 1478 0.433319598598205 2117 3666956
SGTC_3148 9097893 49.47 µM 0.167879757202348 0.440606236358451 no 1479 0.433338937755374 1942 17174100
SGTC_2675 theaflavin digallate 100 µM 0.167312272473391 0.440820355941896 no 1480 0.433562174106636 2063 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_592 k241-0073 46.5 µM 0.167084159988649 0.440906430714418 no 1481 0.433651914654394 2118 4230158
SGTC_302 1094-0063 18.9 µM 0.165774763396412 0.441400565463364 no 1482 0.434167103594793 1994 5440289
SGTC_2603 homopterocarpin 100 µM 0.165204909236134 0.441615643239418 no 1483 0.434391350674777 1995 101795 A weak amylase inhibitor.
SGTC_1704 st028805 70.8 µM 0.164135583858804 0.442019280854401 no 1484 0.434812204900079 2008 2876101
SGTC_1499 4480-0877 67.3 µM 0.163882350945053 0.442114877364991 no 1485 0.434911880575198 2103 2861909
SGTC_3227 9130768 49.47 µM 0.16297179515441 0.442458643894766 no 1486 0.435270320976319 2062 17720899
SGTC_2016 5121758 140 µM 0.162299306265758 0.442712559709295 no 1487 0.435535080478812 2115 2795203
SGTC_1013 4112-3890 241 µM 0.159533068394905 0.443757271722162 no 1488 0.436624453558174 1986 705171
SGTC_875 0709-0210 25.7 µM 0.159242567216978 0.443867006743968 no 1489 0.436738883967138 2167 6251364
SGTC_18 0111-0177 500 nM 0.159165169464446 0.443896243992364 no 1490 0.436769372366846 2063 721752
SGTC_853 0419-0306 21 µM 0.158137613138134 0.444284435556403 no 1491 0.437174181247291 1968 762713
SGTC_1625 st003711 30.1 µM 0.157066776144779 0.444689034621594 no 1492 0.437596110668941 2081 24207034 YER133W GLC7
SGTC_1373 2887-0003 58.5 µM 0.156429038980888 0.444930021078526 no 1493 0.437847424561715 2028 776948
SGTC_1872 amphotericin b 148 nM 0.154949556585131 0.445489162264665 no 1494 0.438430542447907 2104 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_87 0100-0052 35.5 µM 0.154666007646005 0.445596336410667 no 1495 0.438542314715015 2076 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_2201 6605497 169.863 µM 0.153193024688461 0.446153149568952 no 1496 0.439123029119273 2101 670741
SGTC_1354 1498-1681 81 µM 0.151777769443694 0.446688240705548 no 1497 0.439681108195453 2022 5754243
SGTC_1295 1013-0063 9.78 µM 0.151414110588112 0.446825751499982 no 1498 0.439824529576119 2148 6826038
SGTC_2000 st075254 36.4 µM 0.151268138206577 0.446880950025012 no 1499 0.439882101028945 2070 17234175
SGTC_2279 7948423 32.93 µM 0.150332815240202 0.447234660816316 no 1500 0.440251022175973 2162 1247112
SGTC_1630 st005209 31.3 µM 0.149467345784762 0.447561992521572 no 1501 0.440592437092618 2183 3367314
SGTC_2083 5306046 65.942 µM 0.149291353489232 0.447628559453723 no 1502 0.440661868865772 2034 539837
SGTC_93 0109-0045 59.227 µM 0.149057806398583 0.447716898060078 no 1503 0.44075400974177 2168 88733
SGTC_2507 purpurin 79.67 µM 0.148876956439232 0.447785305889372 no 1504 0.440825362325743 1944 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2749 bexarotene 57.39 µM 0.147279169943972 0.448389747643974 no 1505 0.441455836577203 1998 82146 An retinoic acid receptor inhibitor.
SGTC_2991 9074669 71.4286 µM 0.145228008303105 0.449165876438866 no 1506 0.442265426462342 2107 17333109
SGTC_1914 st062367 72.6 µM 0.145001541048932 0.449251580229984 no 1507 0.442354827534693 2037 978205
SGTC_2571 chrysanthemic acid 100 µM 0.142517232139169 0.450191891449933 no 1508 0.443335734510774 1974 2743 An insecticide.
SGTC_2159 5658611 73.75 µM 0.14214770161305 0.450331782821103 no 1509 0.44348167012811 2161 793844
SGTC_975 1335-0046 28.5 µM 0.141741125528361 0.450485705478461 no 1510 0.443642244696214 1996 16486740
SGTC_1554 st069299 38.7 µM 0.140789720072993 0.450845920155307 no 1511 0.444018032182672 2088 24207999
SGTC_2809 7964133 12.99 µM 0.140250401758268 0.451050131195193 no 1512 0.444231075278506 2050 1253665
SGTC_2735 sertaconazole 140 nM 0.139596468349081 0.45129775822419 no 1513 0.444489415574084 2190 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_3109 9122853 49.47 µM 0.137812888379632 0.451973248150507 no 1514 0.445194149051546 2099 1234709
SGTC_1797 st048695 56.8 µM 0.137774609405329 0.451987746963572 no 1515 0.445209275861752 2169 592262 YIL048W NEO1
SGTC_811 0416-0114 265 µM 0.134911272155862 0.453072464888467 no 1516 0.446341013571533 2036 6612453
SGTC_1352 1496-0991 99 µM 0.134030189377371 0.453406316285849 no 1517 0.446689351068103 2094 3000039
SGTC_1989 st071868 50.2 µM 0.133708731979288 0.453528128037686 no 1518 0.446816450025019 2188 16414057
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.131925892202348 0.454203789108697 no 1519 0.447521454302272 2161 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1946 st076057 65.1 µM 0.131522194162605 0.454356801168932 no 1520 0.447681115334677 2108 953009
SGTC_563 tetrahydrosecaminediol 614 µM 0.131307165213812 0.454438305501383 no 1521 0.447766161924381 2166 334274 A psychoactive constituent of the cannabis plant.
SGTC_188 3229-0966 278.469 µM 0.131028844340721 0.454543802782122 no 1522 0.447876244812317 2171 5722370
SGTC_3014 9081533 49.47 µM 0.131025465833365 0.45454508342206 no 1523 0.447877581121417 2184 21367265
SGTC_2269 7935389 174.42 µM 0.130594175638195 0.454708569981043 no 1524 0.448048175217004 2092 97605
SGTC_3146 9095609 49.47 µM 0.129747306765927 0.455029609726813 no 1525 0.448383176745615 2096 17173999
SGTC_736 0958-0254 92.6 µM 0.12936151462308 0.455175869523753 no 1526 0.448535799317369 2123 6812352
SGTC_3340 9146634 11.102 µM 0.126790461001486 0.456150750139114 no 1527 0.44955312291099 2074 4907387
SGTC_311 1315-0136 58 µM 0.126514097998219 0.456255556046401 no 1528 0.449662495061789 2153 6759207
SGTC_3222 9128301 49.47 µM 0.126308800886424 0.456333413409426 no 1529 0.449743744978288 2115 4911358
SGTC_1847 st056231 15 µM 0.123202777377718 0.457511551983023 no 1530 0.45097326314852 2189 5393180
SGTC_1733 st037357 54.9 µM 0.122492279942888 0.457781101977614 no 1531 0.451254579832943 2155 1272339 YGL099W LSG1
SGTC_1497 4476-2978 41.3 µM 0.121286335049571 0.458238660248841 no 1532 0.451732121581645 2143 1528379
SGTC_1849 st056239 19.2 µM 0.120425942811288 0.458565143180405 no 1533 0.452072870777122 1978 5393181
SGTC_892 0929-0076 29 µM 0.118747891921058 0.459201973656729 no 1534 0.452737546342649 2042 5751038
SGTC_341 1486-1430 230 µM 0.118549411681872 0.459277305066016 no 1535 0.452816173115139 2152 2054753 YPL210C SRP72
SGTC_1588 farnesol 29.9 µM 0.118543865075164 0.459279410252269 no 1536 0.452818370397158 2114 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1617 st002906 78 µM 0.118192941962 0.459412603646845 no 1537 0.452957391128856 2109 5150859
SGTC_86 0417-1630 471.922 µM 0.117115944576783 0.45982140800387 no 1538 0.453384087371457 2195 3634867
SGTC_3210 9128157 49.47 µM 0.116442842926591 0.460076924083045 no 1539 0.453650791281901 1944 17590849
SGTC_2678 equilin 100 µM 0.116312346852083 0.460126463601923 no 1540 0.453702500328032 2219 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_123 0083-0120 66.675 µM 0.11512975923827 0.46057543106846 no 1541 0.454171136135975 2016 16001701
SGTC_788 1182-0090 188 µM 0.115009941958447 0.460620922317951 no 1542 0.45421862089729 2187 5715185
SGTC_2787 5284540 71.43 µM 0.114721023789208 0.460730618535258 no 1543 0.454333124687004 2096 736958
SGTC_228 caffeine 993.056 µM 0.114352240871844 0.460870642076291 no 1544 0.454479285914776 2212 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_706 4262-0057 46.9 µM 0.112915282610086 0.461416288266618 no 1545 0.455048860024837 2181 883298
SGTC_1307 1187-1599 12.2 µM 0.112138802971211 0.461711165788821 no 1546 0.455356675560968 2111 1538471
SGTC_3032 9089427 49.47 µM 0.111110416011582 0.462101740532698 no 1547 0.455764394552806 2108 17173707
SGTC_3310 9130229 44.1445 µM 0.110717719777005 0.462250893696524 no 1548 0.45592009701123 2191 7761258
SGTC_496 calpeptin 138 µM 0.110033638581225 0.462510732827933 no 1549 0.456191348575062 2092 73364 A calpain inhibitor.
SGTC_1610 st001799 48.1 µM 0.108622809935284 0.463046667697994 no 1550 0.456750834044865 2038 621897
SGTC_620 0109-0052 432 µM 0.108565757384162 0.463068341805486 no 1551 0.456773460909479 2213 493037
SGTC_2656 pseudo-anisatin 100 µM 0.107712878472292 0.463392361196194 no 1552 0.457111726704621 2152 6708809 A neurotoxin.
SGTC_235 0330-0087 5 mM 0.107262810538459 0.463563357449811 no 1553 0.457290243586935 2158 46494818 YHR062C RPP1
SGTC_2429 5902844 64.44 µM 0.107038071126237 0.46364874618716 no 1554 0.457379388423073 2196 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_289 k017-0060 526 µM 0.106481678226992 0.463860152384516 no 1555 0.457600095707037 2180 5512909
SGTC_394 menadione 8.33 µM 0.104314175459265 0.464683810194608 no 1556 0.458460014447802 2229 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.103847619067135 0.464861122994728 no 1557 0.45864513808993 2238 688664
SGTC_1371 2421-0008 32.7 µM 0.102101518030828 0.465524783010759 no 1558 0.459338048049479 2123 2827552
SGTC_255 tunicamycin 200.472 nM 0.0999753147499626 0.466333042012266 no 1559 0.460181961607952 2223 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3287 9117173 37.0625 µM 0.0997671868745533 0.466412167658858 no 1560 0.460264579561157 2253 2789709
SGTC_3175 9106517 49.47 µM 0.0987855497325403 0.466785382383167 no 1561 0.460654271006152 2128 41468073
SGTC_2666 tannic acid 100 µM 0.0956008008341733 0.467996411254776 no 1562 0.461918814570809 2243 16134267 A thiamine antagonist.
SGTC_1204 4049-0315 18.3 µM 0.0954821814789203 0.468041523103139 no 1563 0.461965921355955 2191 588402
SGTC_942 3253-1115 227 µM 0.0936703901260741 0.46873061188255 no 1564 0.462685496044317 2214 46497897
SGTC_66 0109-0187 42.4 µM 0.0935705052536594 0.46876860440077 no 1565 0.462725170094222 2269 759417
SGTC_3353 9151644 39.2805 µM 0.0929906427472077 0.468989168299848 no 1566 0.462955497508677 2176 4909158
SGTC_1253 0550-0034 176 µM 0.0923647234382029 0.469227261631503 no 1567 0.463204133100428 2157 5969915
SGTC_1258 0671-0043 57.1 µM 0.0912558540988041 0.469649091201075 no 1568 0.463644647446896 2146 4298767
SGTC_2251 lansoprazole 556 µM 0.0909682085532873 0.469758521216051 no 1569 0.463758926094092 2046 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2756 carbadox 75.1 µM 0.0856020475715271 0.471800398766886 no 1570 0.465891385355003 2174 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1155 4088-0394 48.2 µM 0.0853424545300403 0.471899195730066 no 1571 0.465994570395991 2155 2326248
SGTC_1299 1079-1439 3.74 µM 0.0852907272439321 0.471918882515334 no 1572 0.466015131629335 2198 323161
SGTC_867 0518-0118 155 µM 0.0847518674082678 0.472123970183037 no 1573 0.466229330018174 2271 6848158
SGTC_623 k072-0108 16.9 µM 0.0835569242783399 0.472578786537885 no 1574 0.466704358279488 2183 5382803
SGTC_178 4092-0806 87.505 µM 0.0831946322921488 0.47271668832546 no 1575 0.466848390377782 2271 2169044
SGTC_1392 3455-1037 33.9 µM 0.0829107222868323 0.472824757305901 no 1576 0.466961264123 2229 981132
SGTC_814 3342-0569 96 µM 0.0812701862611404 0.473449258395296 no 1577 0.467613541728371 2260 4346283
SGTC_833 3852-0053 558 µM 0.0812424314779528 0.473459824344544 no 1578 0.467624577791376 2222 3123681
SGTC_2906 7926292 26.41 µM 0.0796931959346154 0.474049631148172 no 1579 0.468240635550112 2168 2966319
SGTC_1694 st024011 44.9 µM 0.0776500017806929 0.474827578861801 no 1580 0.469053233375743 2266 2787533
SGTC_755 1995-0008 37.3 µM 0.0774077182854992 0.474919834908785 no 1581 0.469149600451989 2267 689533
SGTC_2267 7931562 200 µM 0.0757535624284444 0.475549735530768 no 1582 0.469807580861264 2199 934880
SGTC_2210 7115885 190.385 µM 0.075688693352197 0.475574438854934 no 1583 0.46983338579359 2258 2927039
SGTC_998 3996-0085 177 µM 0.0746384087761785 0.475974419325312 no 1584 0.470251206777485 2225 715391
SGTC_2563 tomatine 8.54 µM 0.0742892022147696 0.476107413240961 no 1585 0.470390134337485 2322 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_1376 2910-0861 41.3 µM 0.0739138516985817 0.476250366944357 no 1586 0.470539466968699 2264 1112859
SGTC_2843 9000894 45.46 µM 0.0734724975015019 0.476418462315179 no 1587 0.470715064362215 2289 2242070
SGTC_2257 7960413 200 µM 0.0733033159054281 0.476482898396435 no 1588 0.470782376545125 2208 2974689 YIL048W NEO1
SGTC_3240 9133527 49.47 µM 0.0731229439056239 0.476551597236526 no 1589 0.470854141966824 2246 17617455
SGTC_2873 9040596 71.43 µM 0.0724239991097823 0.476817813061933 no 1590 0.471132243206997 2133 6463863
SGTC_2482 5981709 142.65 µM 0.0719846185709293 0.476985170714106 no 1591 0.471307074347446 2233 877755
SGTC_794 k038-0031 316 µM 0.0710295641385688 0.47734895970293 no 1592 0.471687113063932 2268 6624242
SGTC_2798 7813637 45.45 µM 0.0707942268403846 0.477438604747753 no 1593 0.47178076330589 2227 956368
SGTC_2576 guaiol 23.12 µM 0.0691896708400691 0.478049844875641 no 1594 0.472419322440176 2272 227829
SGTC_629 3448-6466 76.7 µM 0.0690617877683198 0.478098562938681 no 1595 0.47247021865864 2266 573744
SGTC_308 4092-1169 104 µM 0.0687865267355849 0.478203426905701 no 1596 0.472579771395812 2243 2268590 YDL196W YDL196W
SGTC_2007 4011539 71.82 µM 0.0679159911033331 0.47853507771563 no 1597 0.472926254542772 2256 45595301
SGTC_1812 st052057 4.327 µM 0.0672258678132956 0.478798006818501 no 1598 0.473200946082562 2272 3645418
SGTC_2197 6588183 93.1375 µM 0.0651057085816548 0.479605820529391 no 1599 0.474044917643677 2280 884136
SGTC_390 dec-rvkr-cmk 16.7 µM 0.0631159824488528 0.48036401346068 no 1600 0.474837073759873 2242 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_532 1548-0774 215 µM 0.0627525500247988 0.480502508562541 no 1601 0.474981775473546 2301 5932993
SGTC_473 2-arachidonoylglycerol 10 µM 0.0622081095902839 0.480709985735832 no 1602 0.475198552240483 2194 5282280 An endocannabinoid.
SGTC_2592 piperlongumine 83.33 µM 0.0620656462448038 0.480764277006685 no 1603 0.475255277279136 2216 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_265 mycophenolic acid 32.932 µM 0.0618044226080369 0.480863827491892 no 1604 0.475359290745602 2265 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1320 1313-0481 95.3 µM 0.0616358694841061 0.480928062532236 no 1605 0.47542640575816 2267 6813365 YLR208W SEC13
SGTC_900 1112-0045 141 µM 0.0615048473380528 0.4809779949827 no 1606 0.475478577049764 2300 56211 YIL048W NEO1
SGTC_2805 7950783 58.44 µM 0.0607588832331124 0.481262287057424 no 1607 0.475775618108326 2256 1178958 YDL195W SEC31
SGTC_2181 6316240 54.2555 µM 0.0576966040575986 0.482429441102473 no 1608 0.476995149380692 2229 12779990
SGTC_2957 9076800 11.52 µM 0.0563854332314346 0.482929226079189 no 1609 0.477517380545311 2260 16459615
SGTC_194 1486-1323 56.904 µM 0.0557215300154358 0.483182299382138 no 1610 0.47778182383746 2262 5178754
SGTC_2309 7664088 163.95 µM 0.0549294212165374 0.483484252234556 no 1611 0.478097346257482 2321 704922
SGTC_541 4513-1321 94 µM 0.0546468561256812 0.483591968697393 no 1612 0.478209904356895 2161 747515
SGTC_835 0312-0010 67.2 µM 0.0525772393192384 0.484380962038506 no 1613 0.479034376136779 2309 1626196
SGTC_2283 7944793 200 µM 0.0523213062753426 0.484478534879285 no 1614 0.479136338306964 2276 2970533
SGTC_3314 9135860 59.4275 µM 0.0518471933584438 0.484659289856456 no 1615 0.479325225615773 2298 25252478
SGTC_1397 3532-0190 20.1 µM 0.0517047787760129 0.484713585861441 no 1616 0.479381964711268 2272 5322280
SGTC_1217 1183-1422 255 µM 0.0498953289737308 0.4854034685941 no 1617 0.480102899804085 2294 2849664
SGTC_1302 1159-0335 255 µM 0.0498123169247311 0.485435119377819 no 1618 0.480135975691188 2287 649284
SGTC_11 0438-0307 1.3 µM 0.0483697585041525 0.485985151656225 no 1619 0.480710780150617 2331 4011476
SGTC_1020 4335-0961 93.3 µM 0.0472194015416418 0.486423789767153 no 1620 0.481169182287141 2247 669075
SGTC_656 4090-1979 187 µM 0.0460024671734234 0.486887832116069 no 1621 0.481654141736562 2330 22330961
SGTC_1196 1588-0294 184 µM 0.0457610404384787 0.4869798952747 no 1622 0.481750355743449 2239 6144269
SGTC_2526 patulin 37.61 µM 0.0456653565356199 0.487016382570723 no 1623 0.48178848823435 2266 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_2585 alliin 100 µM 0.0430894499372573 0.487998697017828 no 1624 0.482815114610046 2287 87310 A garlic compound which reacts with lipids.
SGTC_139 0099-0334 718.624 µM 0.0424068680015235 0.488259010090656 no 1625 0.483087176701345 2336 97690
SGTC_3226 9131256 49.47 µM 0.0420437752413182 0.488397483119481 no 1626 0.48323190067696 2324 17178073
SGTC_3253 9135987 49.47 µM 0.0420209527184977 0.488406187013454 no 1627 0.483240997506934 2316 4182430
SGTC_1109 tnp00067 928.257 nM 0.0418842818337303 0.488458309714054 no 1628 0.48329547334089 2240 676295
SGTC_2413 inermin 26.06 µM 0.0358953111827931 0.490742527579895 no 1629 0.485682917296974 2317 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_3252 9135871 49.47 µM 0.0354630823865588 0.490907394052127 no 1630 0.485855241917284 2329 17682838
SGTC_1527 coumarin 137 µM 0.0349627735091981 0.491098230474762 no 1631 0.486054712574451 2304 323 A hepatotoxic, DNA x-linker.
SGTC_1934 st074720 32.6 µM 0.0341787221822432 0.491397300908062 no 1632 0.486367316932496 2347 17250992
SGTC_1611 st001856 99.4 µM 0.0336904655353295 0.491583545157885 no 1633 0.486561991029302 2324 647478
SGTC_1801 st050089 28.441 µM 0.0334026779225773 0.491693321869182 no 1634 0.486676737091211 2338 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_3213 9129884 49.47 µM 0.033287498844606 0.491737257155822 no 1635 0.486722661356629 2321 17190742
SGTC_1879 gemcitabine 100 µM 0.0330116556813532 0.491842478481428 no 1636 0.486832646409273 2339 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1 0258-0098 57.368 µM 0.0323190193102067 0.492106689498982 no 1637 0.487108820955366 2266 6790032 YDR047W HEM12
SGTC_781 4335-2806 94.4 µM 0.0320800763535408 0.492197836780412 no 1638 0.487204095999252 2336 845254
SGTC_128 0906-2981 13.371 µM 0.031524919966031 0.492409608535747 no 1639 0.487425459379975 2351 6740226
SGTC_130 0136-0219 337.655 µM 0.0302923402250331 0.492879799960848 no 1640 0.487916952692997 2367 234244
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.0285220145057217 0.493555142151172 no 1641 0.488622905066881 2305 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_135 0933-0004 26.348 µM 0.0274154552004923 0.493977280858877 no 1642 0.489064185707327 2334 21230617 YGL099W LSG1
SGTC_852 0418-0143 439 µM 0.0271858021771593 0.494064891511585 no 1643 0.489155769871642 2365 5369229
SGTC_3236 9132701 49.47 µM 0.0270567511345824 0.494114123500013 no 1644 0.489207234857453 2346 24282524
SGTC_3232 9132874 49.47 µM 0.0270349028520329 0.494122458462056 no 1645 0.489215947873848 2354 3784940
SGTC_1449 4112-4002 201 µM 0.026972745507778 0.494146171054121 no 1646 0.489240736027016 2276 2059539
SGTC_1838 st055369 84.5 µM 0.0263938521652333 0.494367015797378 no 1647 0.489471598852361 2353 676036
SGTC_2812 7970281 58.44 µM 0.0262236858518393 0.494431933675776 no 1648 0.489539461899579 2352 2233435
SGTC_1056 3448-1962 115 µM 0.0257764594588108 0.494602549744829 no 1649 0.489717819119916 2327 715507
SGTC_2565 isoliquiritigenin 100 µM 0.0255839544002555 0.494675990386148 no 1650 0.489794592207782 2278 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_502 l-744,832 89.3 µM 0.024937308114602 0.494922687121508 no 1651 0.49005248445352 2372 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2679 rapamycin 1 nM 0.0241110944038518 0.495237891969192 no 1652 0.490381996920711 2355 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_248 streptozotocin 5.23457 mM 0.0240110548617041 0.495276057782938 no 1653 0.490421895372786 2355 5300 DNA alkylating agent.
SGTC_2234 tolnaftate 200 µM 0.0237624006400437 0.495370921365575 no 1654 0.490521065758606 2357 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_2588 indole-3-carbinol 100 µM 0.0232893835642071 0.495551381897221 no 1655 0.490709720053507 2365 3712 Induces cell cycle arrest.
SGTC_1138 3761-0006 1.03 µM 0.022680697873471 0.495783602635309 no 1656 0.490952486370608 2356 12061087
SGTC_2916 7875993 68.79 µM 0.0216465920236737 0.496178129392846 no 1657 0.491364933583052 2366 1299250
SGTC_2361 9034121 116 µM 0.0215080252978109 0.496230994951534 no 1658 0.491420200841442 2353 6496917
SGTC_1360 1598-0022 39.8 µM 0.021286408432428 0.496315545685781 no 1659 0.491508592941837 2355 761525
SGTC_2933 9026794 32.47 µM 0.0212442707439668 0.496331621974327 no 1660 0.491525399646813 2357 17586027
SGTC_1286 0929-0070 131 µM 0.0196217605142606 0.496950643188783 no 1661 0.492172552396987 2343 1420408
SGTC_963 1269-2853 151 µM 0.0194796076953882 0.497004877801039 no 1662 0.492229252329444 2352 3668223
SGTC_1680 diphenhydramine 100 µM 0.0192546157990512 0.497090717564065 no 1663 0.492318994277443 2322 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.0190219409218827 0.497179488708753 no 1664 0.492411801125413 2363 4620898
SGTC_1973 st070275 50.2 µM 0.0189952000770663 0.497189691002763 no 1665 0.492422467251877 2380 17118334
SGTC_3118 9124250 49.47 µM 0.0189794142605416 0.497195713683256 no 1666 0.492428763746417 2301 1504786
SGTC_250 brefeldin a 552.239 µM 0.018852397345278 0.497244173809598 no 1667 0.492479427099432 2359 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1274 0865-0114 173 µM 0.0181857603826703 0.497498513115107 no 1668 0.492745331163928 2355 870624
SGTC_43 0570-0105 72.5 µM 0.0154620370044898 0.498537693744105 no 1669 0.493831785475981 2380 1114046 YDL195W SEC31
SGTC_3089 9117425 49.47 µM 0.0149285602780483 0.498741232199031 no 1670 0.494044587326163 2319 9401657
SGTC_1506 4226-2149 212 µM 0.0145047728377853 0.498902920914763 no 1671 0.494213635745454 2313 991114
SGTC_2597 laccaic acid a 100 µM 0.014109530158494 0.499053719037126 no 1672 0.494371298623022 2361 5491415 A textile dye.
SGTC_2292 7671323 168.05 µM 0.014038348372187 0.499080877252091 no 1673 0.494399693234887 2366 937504
SGTC_1340 1486-1359 257 µM 0.0131992021023896 0.499401039703635 no 1674 0.494734433107814 2311 4309068
SGTC_782 0083-0095 30.5 µM 0.0131515972586571 0.499419202561956 no 1675 0.494753423044415 2383 3591729 An indicator and reagent.
SGTC_842 0271-0008 11.1 µM 0.0129806879773519 0.49948441024416 no 1676 0.494821600162771 2366 1221709
SGTC_1553 gossypol 38.6 µM 0.0126131630968293 0.499624633484325 no 1677 0.494968209370937 2377 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_719 2810-4230 27.3 µM 0.0118057245604304 0.499932698882727 no 1678 0.495290306724679 2391 721079
SGTC_3346 9158254 43.5805 µM 0.0114529325464294 0.499932698882727 no 1679 0.495431040857668 2370 17639500
SGTC_943 3253-1379 105 µM 0.0106129203247976 0.499612205513564 no 1680 0.495766136843601 2380 668464
SGTC_1192 1488-0095 21.4 µM 0.0101800916786659 0.499447066678217 no 1681 0.495938801157699 2373 915875
SGTC_2081 5214970 32.255 µM 0.00918423130572138 0.499067112514506 no 1682 0.496336073328 2387 2063512
SGTC_1523 st012844 44.7 µM 0.00912984825646549 0.499046363576794 no 1683 0.496357768116095 2352 4274103
SGTC_2484 5809818 12.04 µM 0.00848983019795684 0.498802175660729 no 1684 0.496613088467181 2387 2870548
SGTC_3307 9126885 69.2785 µM 0.00717242249290373 0.498299542854157 no 1685 0.497138641947814 2388 24824909
SGTC_2434 5670830 169.91 µM 0.00636757607523778 0.497992469706331 no 1686 0.49745972184629 2380 1549830
SGTC_401 neomycin 50 µM 0.00490668031155392 0.497435097139932 no 1687 0.498042525621844 2382 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2881 9058953 51.95 µM 0.00478880886262888 0.497390126091361 no 1688 0.498089548973903 2387 17122249
SGTC_695 3505-6186 243 µM 0.00327234206305599 0.496811557402407 no 1689 0.498694526724994 2400 1819379
SGTC_1230 0170-0365 3.77 µM 0.00303417941804101 0.496720693182749 no 1690 0.498789539401119 2399 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2984 9022109 38.96 µM 0.00251129643919658 0.496521202577723 no 1691 0.498998138724841 2402 6459207
SGTC_1030 k029-0042 36.7 µM 0.00167255191812957 0.496201206139204 no 1692 0.49933274863479 2394 6080581
SGTC_271 rotenone 740 µM 7.87181844471943e-05 0.49559313620427 no 1693 0.49996859598802 2405 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1429 4049-0205 9.46 µM 6.06217610864136e-05 0.495586232220932 no 1694 0.499975815416405 2405 22774478
SGTC_2491 paeonol 100 µM 0 0.495563104366016 no 1695 0.5 2397 11092 Increases levels of cortical cytochrome oxidase.
SGTC_1344 1488-0097 29.1 µM -0.000208911663342322 0.495483402430639 no 1696 0.49991665630523 2401 747966
SGTC_41 0478-0632 82.643 µM -0.000800570432118324 0.49525767955038 no 1697 0.499680618640305 2408 3750424
SGTC_322 k048-0136 19.3 µM -0.00096696877173096 0.495194197431181 no 1698 0.499614235333246 2413 6823282
SGTC_2037 5169046 200 µM -0.00130340916063313 0.495065843465765 no 1699 0.499480015124392 2414 5718022
SGTC_1657 st012939 43.4 µM -0.00158320867891308 0.494959098710449 no 1700 0.499368391383143 2409 24207257
SGTC_2421 5690543 90.72 µM -0.00267143674378174 0.494543938386223 no 1701 0.498934252201119 2391 3397993
SGTC_237 nikkomycin 200 µM -0.00267381191689636 0.494543032261103 no 1702 0.498933304647525 2408 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_1285 0929-0069 65.5 µM -0.00328322975505479 0.494310541177877 no 1703 0.498690183187653 2413 1206237
SGTC_2959 9079155 11 µM -0.00457965462964325 0.493815965491204 no 1704 0.498172988524992 2419 16189457
SGTC_2296 7971656 126.45 µM -0.00506273282191921 0.493631677427511 no 1705 0.497980270451001 2419 666570
SGTC_3093 9117344 49.47 µM -0.00706199858244299 0.49286899836483 no 1706 0.497182693598716 2457 24824913
SGTC_2703 st077852 53.4 µM -0.00732510935470939 0.492768628858844 no 1707 0.497077730303347 2428 6281836
SGTC_2544 sphondin 68.51 µM -0.00782911482034375 0.492576365952373 no 1708 0.49687666698755 2421 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_547 1120-0019 610 nM -0.00788594804086693 0.492554685897707 no 1709 0.496853994512874 2419 3676939
SGTC_775 4577-0580 57.3 µM -0.00839393020881102 0.49236090794308 no 1710 0.496651345664296 2445 2006902
SGTC_3322 9139058 2.11 µM -0.00841679807198197 0.492352184671546 no 1711 0.496642223029079 2480 4908926 YPR165W RHO1
SGTC_2974 9094440 9.66 µM -0.00929871612757636 0.49201576732072 no 1712 0.496290402442422 2499 25236134
SGTC_757 1066-0008 322 µM -0.0100723889466274 0.491720645975224 no 1713 0.495981766128317 2488 6842497
SGTC_3278 9139605 49.47 µM -0.0106743452710091 0.49149102986742 no 1714 0.495741633223499 2453 7958859
SGTC_2752 diclazuril 33.15 µM -0.011465238594574 0.491189348080826 no 1715 0.495426131777076 2431 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_646 4092-0839 27.3 µM -0.0116109890480303 0.491133752939273 no 1716 0.495367989629161 2441 877796
SGTC_543 3844-1095 191 µM -0.0131798617627558 0.490535332305301 no 1717 0.494742148115916 2447 4230703
SGTC_2071 5230951 39.92 µM -0.0142656363799368 0.490121193869253 no 1718 0.494309027518631 2435 1799272
SGTC_3247 9135149 49.47 µM -0.0143853887111531 0.490075518327408 no 1719 0.494261258152435 2429 8934436 YOR116C RPO31
SGTC_1959 st077091 55.8 µM -0.0149012688179998 0.489878754522659 no 1720 0.494055473832525 2431 821356 YKL052C ASK1
SGTC_176 1486-1328 72.834 µM -0.0156352323852915 0.489598814927836 no 1721 0.493762698867591 2455 22310231
SGTC_3170 9103054 49.47 µM -0.0165076933046022 0.489266058007865 no 1722 0.493414682277755 2447 16432970
SGTC_1072 oxiconazole 14.9 nM -0.0173408888835696 0.488948283874549 no 1723 0.493082332944163 2437 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_544 k015-0020 52.4 µM -0.017630251809704 0.488837924798702 no 1724 0.492966911485075 2455 3008304
SGTC_12 0849-0099 9.267 µM -0.0177095030439428 0.488807699606928 no 1725 0.492935299752337 2438 6071388
SGTC_545 4218-0007 221 µM -0.0180693868911676 0.488670446299657 no 1726 0.492791749842557 2450 2840508
SGTC_3329 9141233 27.5565 µM -0.0183512301079244 0.488562957238762 no 1727 0.492679329309053 2445 4909101 YNL103W MET4
SGTC_2287 7945887 168.79 µM -0.0197623902275185 0.488024783169137 no 1728 0.492116460135256 2444 1245853
SGTC_2023 5144124 124 µM -0.0205497065901394 0.487724533777918 no 1729 0.49180243015464 2449 2830192
SGTC_2688 kanamycin b 96.69 µM -0.0208469250103114 0.487611188956285 no 1730 0.491683882557573 2448 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_1255 0566-0045 221 µM -0.0208861191596034 0.487596242265833 no 1731 0.491668249758 2472 2788469
SGTC_42 0133-0086 60.653 µM -0.0239331503735885 0.486434311754473 no 1732 0.490452965838135 2456 162923 Model of phenazepam hydroxylation.
SGTC_3147 9097027 49.47 µM -0.0245031735180224 0.486216956177506 no 1733 0.49022562618742 2471 25236841
SGTC_2046 4110841 106 µM -0.0249983700401881 0.486028136067957 no 1734 0.490028131861485 2456 44119630 YMR134W ERG29
SGTC_2753 fluvastatin 17.09 µM -0.025213989793089 0.485945920502976 no 1735 0.489942139131481 2474 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_1874 staurosporine 7.6 µM -0.0272860814979163 0.485155865272898 no 1736 0.489115779046038 2466 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1263 0774-1208 64.8 µM -0.0275110251392419 0.485070101332088 no 1737 0.489026073193541 2461 906585
SGTC_2188 6126565 140.678 µM -0.0279038829218995 0.484920318665195 no 1738 0.488869405763434 2454 874518
SGTC_349 k015-0014 24 µM -0.0283032344058463 0.484768062362331 no 1739 0.488710150475934 2461 2196908
SGTC_1214 0358-0031 63.7 µM -0.0283304491740263 0.484757686570641 no 1740 0.48869929770624 2510 4301366
SGTC_2764 methyldopa 94.69 µM -0.0284106292259367 0.484727117510587 no 1741 0.48866732336396 2472 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2595 hexamethylquercetagetin 100 µM -0.028602266445729 0.484654055192011 no 1742 0.48859090223149 2494 386331
SGTC_2523 spermine 47.74 µM -0.0286202530811999 0.484647197754655 no 1743 0.488583729538517 2460 1103 A DNA binding polyamine.
SGTC_1591 genipin 88.4 µM -0.0299737669428341 0.484131181314016 no 1744 0.488043987357246 2540 442424 A DNA cross-linking agent.
SGTC_203 k066-0004 30.888 µM -0.0309394754299745 0.483763028795829 no 1745 0.487658904070304 2445 6795412
SGTC_2866 9034245 58.44 µM -0.0314603285794492 0.483564472118229 no 1746 0.487451214839916 2522 6462273
SGTC_1390 3413-2614 145 µM -0.0315168811421766 0.483542913716073 no 1747 0.487428664813893 2472 3421432
SGTC_336 4111-0029 111 µM -0.0320248572084318 0.483349270326906 no 1748 0.487226113937834 2504 3131175
SGTC_1995 st072814 61.1 µM -0.0320492101917108 0.483339986928335 no 1749 0.487216403487694 2472 5769371
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.0335767838759143 0.482757691504695 no 1750 0.486607317805179 2483 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3185 9108267 49.47 µM -0.034016234047736 0.482590184362849 no 1751 0.486432102647227 2489 4910486
SGTC_359 0081-0058 15.9 µM -0.0342429977390331 0.482503749056147 no 1752 0.486341689696529 2503 3494159
SGTC_2021 4019055 173 µM -0.0355541720863179 0.482003986192773 no 1753 0.485818925287113 2504 44827708 YER133W GLC7
SGTC_2050 5263056 171 µM -0.0363216432356738 0.481711472506083 no 1754 0.485512946259001 2484 763468 YGL055W OLE1
SGTC_3208 9114115 49.47 µM -0.0390448711298832 0.480673622901122 no 1755 0.484427306940812 2515 650895
SGTC_2282 7944268 200 µM -0.0394961069234052 0.480501664852713 no 1756 0.48424742866092 2507 2970414
SGTC_1259 0671-0132 43 µM -0.041803277157949 0.479622500120434 no 1757 0.483327761252102 2505 X1259
SGTC_2972 9093619 59.92 µM -0.0424227607241945 0.479386457908273 no 1758 0.48308084212289 2478 25236256
SGTC_1421 4029-0249 71.4 µM -0.0428298565653897 0.479231345855336 no 1759 0.482918581861389 2501 2894095
SGTC_1814 st052110 31.539 µM -0.0443553482803738 0.478650129686675 no 1760 0.482310576751929 2506 674163
SGTC_960 1222-0186 7.7 µM -0.0447132355933041 0.478513780252227 no 1761 0.482167941886187 2531 3126296
SGTC_1800 st050079 29.0735 µM -0.0454020355197737 0.478251365410419 no 1762 0.481893429276131 2482 3645560
SGTC_903 1134-0042 114 µM -0.0463688887949485 0.47788303541207 no 1763 0.481508116487643 2497 701009
SGTC_2024 5144227 134 µM -0.0482582840104808 0.477163310966047 no 1764 0.480755200165449 2521 3475211
SGTC_1046 2001-0062 216 µM -0.0482832064911148 0.477153817775968 no 1765 0.480745269110935 2497 739778
SGTC_2807 7945238 51.95 µM -0.0506283953608981 0.47626057365274 no 1766 0.479810817804315 2543 17148797
SGTC_1381 2324-0066 62.1 µM -0.0510457876816751 0.476101608112332 no 1767 0.479644517394362 2551 10885928
SGTC_2644 guaiazulene 100 µM -0.0515057755490566 0.475926424293597 no 1768 0.479461249869652 2525 3515 A coloring agent.
SGTC_3271 9137798 49.47 µM -0.0518967276644855 0.475777536013444 no 1769 0.479305490854796 2501 6498326
SGTC_2587 piperic acid 92.2 µM -0.0529047867213455 0.475393647415216 no 1770 0.478903885243768 2533 5370536
SGTC_2628 lathosterol 100 µM -0.0531249228447035 0.475309818301648 no 1771 0.478816186964817 2564 6710616
SGTC_3008 9078912 71.4286 µM -0.0543738050654879 0.474834257500661 no 1772 0.478318674250941 2528 16648731
SGTC_64 000l-0018 272.079 µM -0.0546008985471469 0.474747786599122 no 1773 0.47822821144564 2515 6811119
SGTC_3082 9117008 49.47 µM -0.0558349081476268 0.474277930855571 no 1774 0.477736662814258 2548 41448529
SGTC_1247 0448-0043 5.84 µM -0.0567836733864444 0.473916707718403 no 1775 0.477358759850938 2553 3089013 YGL099W LSG1
SGTC_396 dithiazanine 1.25 µM -0.0569463558970264 0.473854771794902 no 1776 0.47729396376727 2514 10578 An antihelmenthic.
SGTC_1156 4092-0367 4.88 µM -0.0570202608399284 0.47382663516899 no 1777 0.477264527790382 2535 1357585
SGTC_1764 st044502 93.5 µM -0.0576886194415094 0.473572187824492 no 1778 0.476998329484848 2564 8407
SGTC_583 1488-1091 88.9 µM -0.0584066077520149 0.47329885822563 no 1779 0.476712375767306 2489 4303273
SGTC_3323 9138564 53.9225 µM -0.059483502793682 0.472888920715855 no 1780 0.476283502536089 2534 43912313 YNL103W MET4
SGTC_710 3448-4187 58 µM -0.0607651395029895 0.472401082435321 no 1781 0.475773126820945 2531 3946412
SGTC_1167 k781-0610 148 µM -0.0608324710776877 0.472375454688667 no 1782 0.47574631500968 2553 4525169
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.062927684177583 0.471578032274459 no 1783 0.47491204487026 2546 6857784
SGTC_254 nsc-64875 3.808 µM -0.0655790739734396 0.470569096880869 no 1784 0.473856474896508 2635 56993
SGTC_660 4031-1742 102 µM -0.0663726872990869 0.470267139030767 no 1785 0.47354055730934 2521 6738706
SGTC_1732 st034308 51.822 µM -0.06825906196931 0.46954947097229 no 1786 0.472789705950523 2500 830119
SGTC_668 1682-0499 62.6 µM -0.0685282541131957 0.469447065286267 no 1787 0.47268256470327 2563 682214
SGTC_1084 voriconazole 435 nM -0.0692825870570506 0.469160113827057 no 1788 0.472382342972162 2538 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_599 1935-0052 86.5 µM -0.0699180031648454 0.46891841126146 no 1789 0.472129461871181 2536 9557311
SGTC_2915 7971052 15.16 µM -0.0700582106695377 0.468865080011363 no 1790 0.472073663995408 2515 5741558
SGTC_935 2996-0153 430 µM -0.0701039458942552 0.468847683654607 no 1791 0.472055463031212 2535 23738523
SGTC_2601 securinine 100 µM -0.0705977252734038 0.468659868054003 no 1792 0.471858960433099 2564 442872 A GABA receptor antagonist.
SGTC_3290 9121031 71.43 µM -0.0719042793905376 0.468162936449166 no 1793 0.471339042203249 2568 17014854
SGTC_1753 st043925 64 µM -0.0741798113764868 0.467297585046328 no 1794 0.470433654886889 2540 670181
SGTC_2801 7907800 81.82 µM -0.0767299980623794 0.466327970323234 no 1795 0.469419169939524 2605 6620925
SGTC_819 1013-0258 27.7 µM -0.0777462117939959 0.465941647771483 no 1796 0.46901496681569 2550 5753198
SGTC_500 h-89 112 µM -0.0787129077376812 0.465574179618586 no 1797 0.468630489223482 2646 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1005 4092-0690 4.4 µM -0.0794918421858062 0.465278106198195 no 1798 0.468320710036879 2580 1529343
SGTC_306 1672-3436 11.6 µM -0.0799261820884179 0.465113021693882 no 1799 0.468147983072188 2617 6797378
SGTC_809 3998-0021 90 µM -0.0802345931826382 0.464995804027045 no 1800 0.468025338729604 2536 715485
SGTC_2864 9034755 47.6 µM -0.0808641489076413 0.464756538503183 no 1801 0.467774995793572 2543 4930451
SGTC_1856 st057054 55.7 µM -0.0820820174523162 0.464293718254177 no 1802 0.467290746429524 2639 1266018
SGTC_3023 9089636 49.47 µM -0.082115238852517 0.46428109397228 no 1803 0.467277537598446 2534 17249241
SGTC_2339 9000433 200 µM -0.0825271766678677 0.464124558736131 no 1804 0.467113754091936 2608 2988954
SGTC_425 3825-7017 13.1 µM -0.082660193633584 0.464074013840132 no 1805 0.467060868692931 2781 3397440
SGTC_469 w7 172 µM -0.0836119259233467 0.463712383631538 no 1806 0.466682492313083 2543 45115570 A P450 inhibitor.
SGTC_391 gliotoxin 8.33 µM -0.0836161369440973 0.463710783634213 no 1807 0.466680818221147 2653 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1411 3909-8223 150 µM -0.0850555141349006 0.463163919996905 no 1808 0.466108628333342 2570 X1411
SGTC_71 0417-1750 47.813 µM -0.0858514888124185 0.462861534573125 no 1809 0.46579223768997 2558 6811472
SGTC_1474 0330-0125 5.35 µM -0.085939897886727 0.462827949881632 no 1810 0.46575709744527 2587 X1474
SGTC_1666 st014829 29 µM -0.0861560425175763 0.462745842336524 no 1811 0.465671186854851 2541 3858230
SGTC_2358 9037157 4 µM -0.0866496888553717 0.462558325297292 no 1812 0.465474984200759 2632 2388925
SGTC_1725 st036284 20.55 µM -0.0890386853202211 0.4616509568 no 1813 0.464525582879507 2708 707914
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.089926053982459 0.4613139744957 no 1814 0.464172988471264 2651 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3218 9131285 49.47 µM -0.0907861018247306 0.460987393900036 no 1815 0.463831276790068 2593 17156417
SGTC_3339 9145883 14.936 µM -0.0920886142315468 0.460492849163807 no 1816 0.463313817269764 2606 2030670
SGTC_965 1291-5240 308 µM -0.0933538536046165 0.460012514946469 no 1817 0.462811224922831 2626 2834598
SGTC_1896 st058441 89 µM -0.0936977657503649 0.459881962538416 no 1818 0.462674622571825 2590 688759
SGTC_2109 5483026 200 µM -0.0937649330426346 0.459856465682955 no 1819 0.46264794414938 2613 759335
SGTC_1899 st063254 59.6 µM -0.0939258512102191 0.459795381455746 no 1820 0.462584029157613 2555 3093813
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.0939928753215994 0.459769939511717 no 1821 0.462557408175353 2549 756377
SGTC_1290 0986-0249 10.2 µM -0.0941112032359792 0.459725023359075 no 1822 0.462510410493465 2591 53329
SGTC_2840 9008771 71.43 µM -0.0955557454025669 0.459176730482082 no 1823 0.461936707174194 2718 2992978
SGTC_247 mechlorethamine 29.705 µM -0.0965492817837783 0.458799667128543 no 1824 0.461542167752352 2566 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_1226 3909-7979 35.4 µM -0.0966550039388164 0.458759546012545 no 1825 0.461500187053846 2678 6615510
SGTC_2834 9001755 58.44 µM -0.0973670974506235 0.458489320465125 no 1826 0.461217436488774 2716 2989575
SGTC_2529 gangaleoidin 93.61 µM -0.0976727856037541 0.45837332367295 no 1827 0.461096063073712 2612 4565183
SGTC_2817 7995342 71.43 µM -0.0980998099723259 0.458211290432138 no 1828 0.46092651920997 2578 18879975
SGTC_3075 9116269 49.47 µM -0.0983274751210835 0.458124906343975 no 1829 0.460836130948452 2694 17015205 YNL244C SUI1
SGTC_3176 9106582 49.47 µM -0.0986557173805561 0.458000363278964 no 1830 0.460705814840727 2565 17018027
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.0990603643359922 0.457846836097676 no 1831 0.460545170962929 2693 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1696 st025591 34.7925 µM -0.0992557521769521 0.457772706208578 no 1832 0.460467604758978 2602 2787147
SGTC_974 1326-0144 138 µM -0.0997413824597048 0.457588465088215 no 1833 0.46027482294075 2591 5411856
SGTC_2996 9066192 71.4286 µM -0.100002604194332 0.457489365099363 no 1834 0.460171128981531 2612 6472854
SGTC_1455 4262-0120 131 µM -0.100985314209669 0.457116576999752 no 1835 0.459781059068979 2779 1529587
SGTC_1160 4092-0570 10.5 µM -0.101633705991119 0.456870632160867 no 1836 0.459523712226747 2586 4994975
SGTC_1120 ficusin 1.78878 µM -0.101718388964162 0.456838511842191 no 1837 0.459490102785668 2731 6199 A DNA cross-linker.
SGTC_1080 nisoldipine 24.4 µM -0.101928836890099 0.456758689998979 no 1838 0.459406580317068 2578 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1493 4348-0038 111 µM -0.102107052873235 0.456691094934305 no 1839 0.459335851446827 2588 800424
SGTC_873 0591-4978 488 µM -0.102154459358969 0.456673114465765 no 1840 0.459317037373515 2744 3305145
SGTC_2796 7949634 45.45 µM -0.102732378543416 0.456453926755157 no 1841 0.459087687615585 2579 2971588
SGTC_2289 7946404 165.07 µM -0.103601165378715 0.456124446470009 no 1842 0.458742931401785 2611 1246120 YPR165W RHO1
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.103957771798941 0.455989215128379 no 1843 0.458601430076675 2642 688798
SGTC_2297 7971671 152.32 µM -0.10550160458507 0.455403825960698 no 1844 0.457988898410867 2667 909016
SGTC_578 3460-0051 92 µM -0.108062055809215 0.454433170338795 no 1845 0.456973233462531 2587 2876744
SGTC_1165 k072-0275 30.3 µM -0.108434201064358 0.454292114241618 no 1846 0.456825636271459 2613 6153523 YGL055W OLE1
SGTC_3040 9091894 49.47 µM -0.108674808181028 0.454200918777118 no 1847 0.456730211824207 2632 25236966
SGTC_313 3474-0040 5.03 µM -0.10910802916352 0.454036724451158 no 1848 0.456558403280556 2585 1043375 YIL048W NEO1
SGTC_263 alizarin 107.927 µM -0.109219628256807 0.45399442874548 no 1849 0.456514146171253 2581 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2437 5741531 144.16 µM -0.10994899967739 0.453718012138188 no 1850 0.456224910976597 2706 2262990
SGTC_3179 9107801 49.47 µM -0.110773084229428 0.453405728203507 no 1851 0.455898144820733 2629 4818259
SGTC_2266 7929956 200 µM -0.11146362342442 0.453144072987862 no 1852 0.455624355053958 2583 2967153
SGTC_207 4185-0010 4.486 µM -0.112241614730858 0.452849305285936 no 1853 0.455315916919213 2605 3761753
SGTC_2163 5671233 125 µM -0.112452943962323 0.452769240707204 no 1854 0.455232139143545 2642 701023
SGTC_920 mycophenolic acid 780.421 nM -0.113731027397732 0.452285064721274 no 1855 0.454725507894404 2634 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_676 falcarinol 140 µM -0.114200154696909 0.452107363121847 no 1856 0.454539564640949 2641 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1315 1237-0019 3.69 µM -0.114516819926426 0.451987418334006 no 1857 0.454414056868514 2654 825140
SGTC_2119 5528445 120.635 µM -0.115090229203847 0.45177023654742 no 1858 0.454186802203347 2727 791935
SGTC_3142 9086498 49.47 µM -0.115179648477778 0.451736369825288 no 1859 0.454151364734925 2660 25236367
SGTC_439 amiodarone 34.4 µM -0.115230396754576 0.451717149541511 no 1860 0.454131253008871 2689 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_2671 danthron 100 µM -0.115659867614353 0.451554497287609 no 1861 0.453961056864526 2645 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2619 obliquin 87.91 µM -0.116671578036162 0.451171367324199 no 1862 0.453560156931903 2627 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3238 9133470 49.47 µM -0.116773877612207 0.451132629483574 no 1863 0.45351962237377 2704 3534688
SGTC_1677 st019204 53.9 µM -0.117313007211024 0.450928484659328 no 1864 0.453306008970134 2742 3945625
SGTC_893 0958-0369 48.9 µM -0.117577253111933 0.45082843101828 no 1865 0.453201314646897 2766 6819948
SGTC_1698 5-fluorocytosine 1.055 µM -0.11768267237965 0.450788516108561 no 1866 0.453159548401482 2618 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_805 3852-0218 479 µM -0.119038112705863 0.450275350055339 no 1867 0.452622580432541 2633 6615355
SGTC_1751 st044839 27.194 µM -0.119321486173245 0.450168076101752 no 1868 0.452510330800165 2590 5291326
SGTC_1097 itavastatin 7.23 µM -0.120167287948093 0.449847910783722 no 1869 0.452175315198874 2630 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1583 clindamycin 39.6 µM -0.121375228519777 0.449390720014564 no 1870 0.451696918290524 2625 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2244 6635614 200 µM -0.123477377479935 0.448595242812441 no 1871 0.45086454367341 2604 836499
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.123709437699523 0.448507441177721 no 1872 0.450772669431648 2663 1273210
SGTC_124 0136-0217 7.121 µM -0.124955881550876 0.448035883541529 no 1873 0.450279238962889 2649 3976905
SGTC_2090 5301565 104.445 µM -0.125053480306124 0.447998962836729 no 1874 0.450240605719983 2660 2056344
SGTC_2150 5556613 200 µM -0.125611070990503 0.44778804009522 no 1875 0.450019899495319 2661 743190
SGTC_1491 4138-0063 26.5 µM -0.125985020439829 0.447646592549577 no 1876 0.449871891023676 2619 23883227
SGTC_435 c-PAF 6.7 µM -0.127891997936459 0.446925376281336 no 1877 0.449117221881979 2643 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_261 5-fluorouridine 15.376 µM -0.128277941055635 0.446779434399819 no 1878 0.448964510678317 2743 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_185 k048-0037 25.491 µM -0.128722134612187 0.446611474416542 no 1879 0.448788760115253 2611 6827589
SGTC_1243 0416-0003 5.65 µM -0.13214395705839 0.445317926518631 no 1880 0.447435214020237 2710 2141977
SGTC_3195 9113082 49.47 µM -0.133091764605484 0.444959730178078 no 1881 0.447060404049148 2621 17018038
SGTC_1507 4075-3230 155 µM -0.133864558207841 0.444667708518549 no 1882 0.446754838219547 2588 659771
SGTC_2036 5160441 105 µM -0.134204591067185 0.444539227104142 no 1883 0.446620397804977 2685 134534 YIL048W NEO1
SGTC_1674 st016616 23.6 µM -0.135401474336625 0.444087031209037 no 1884 0.446147229258097 2611 625830
SGTC_987 1497-1013 404 µM -0.136496792557197 0.443673271487883 no 1885 0.445714279994623 2645 1676435
SGTC_1293 1000-1278 195 µM -0.136504576173889 0.443670331422656 no 1886 0.445711203575344 2739 678847
SGTC_108 0509-0257 621.132 µM -0.137969139129768 0.443117184996414 no 1887 0.445132403829951 2742 536624
SGTC_890 0929-0006 47.2 µM -0.138451118844973 0.442935171699108 no 1888 0.444941949492779 2653 1378169
SGTC_1023 4482-3888 16 µM -0.139118767033209 0.44268306304738 no 1889 0.444678149242542 2836 3303168
SGTC_1428 4049-0204 61.7 µM -0.140170504376694 0.442285966741042 no 1890 0.44426263794752 2760 X1428
SGTC_1865 st057639 52.2 µM -0.140709835268758 0.442082358227039 no 1891 0.444049587492274 2624 688818
SGTC_112 phenothiazine 287.218 µM -0.14097138914111 0.441983621761945 no 1892 0.443946272375903 2641 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_376 3970-0862 59.1 µM -0.142085739780398 0.441562995379529 no 1893 0.443506140950344 2753 3135186
SGTC_1701 st028638 40.4 µM -0.143391917009545 0.441070045433987 no 1894 0.442990333150584 2679 3490878
SGTC_221 trifluoperazine 10.304 µM -0.144044806813568 0.440823679663355 no 1895 0.442732543916926 2668 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2930 9013230 14.89 µM -0.144699695465135 0.440576582641176 no 1896 0.442473989805798 2753 2995857
SGTC_810 3825-7150 143 µM -0.144760136967701 0.440553778531697 no 1897 0.442450128358091 2708 22330411 YGL099W LSG1
SGTC_2650 prasterone 100 µM -0.145108775508184 0.440422243768939 no 1898 0.442312494886549 2655 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_330 1488-0319 80.1 µM -0.145381863889359 0.44031921725076 no 1899 0.442204691524517 2734 6846614
SGTC_2055 5235184 200 µM -0.145668913382873 0.440210928057833 no 1900 0.442091381539153 2791 2836034
SGTC_2231 micatex 6.853 µM -0.146060500327306 0.440063209407823 no 1901 0.441936814057527 2691 20737 An antifungal of unknown mechanism.
SGTC_1640 st009078 66.4 µM -0.148423293460409 0.439172068860176 no 1902 0.441004359069355 2786 690618
SGTC_304 1310-0298 97 µM -0.148785811670472 0.439035370262833 no 1903 0.440861323331714 2673 1550234
SGTC_3320 9137005 35.139 µM -0.148896635798597 0.438993582080426 no 1904 0.440817597933644 2731 4908713
SGTC_499 genistein 192 µM -0.148904025367581 0.438990795737933 no 1905 0.440814682422303 2730 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.14942986060329 0.438792529824379 no 1906 0.440607225442762 2804 5393153
SGTC_1895 st058434 18.3 µM -0.15155314348142 0.437992103781817 no 1907 0.439769696237988 2808 5393175
SGTC_1693 xanthone 101.9 µM -0.151780589764024 0.437906377043026 no 1908 0.439679995936013 2720 7020 An insecticide.
SGTC_1037 k284-1091 78.7 µM -0.152468480396562 0.437647122055467 no 1909 0.439408724379853 2664 3334711
SGTC_1631 benzylvanillin 81.9 µM -0.154968610955789 0.436705089024721 no 1910 0.438423031574081 2811 75506
SGTC_1452 4194-0072 190 µM -0.15786304009376 0.435614935335882 no 1911 0.437282361272276 2856 1343545
SGTC_934 2950-0684 338 µM -0.158516334023437 0.435368946993303 no 1912 0.437024975347613 2907 1121253
SGTC_420 mitomycin C 81.9 mM -0.158669904497967 0.435311125887888 no 1913 0.436964475239246 2686 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_88 0180-0332 8.668 µM -0.158720084753838 0.435292232726025 no 1914 0.43694470671366 2663 3101745
SGTC_1218 1348-1416 30.7 µM -0.160224399175884 0.434725918265835 no 1915 0.436352154960206 2679 6787668
SGTC_2990 9074105 71.4286 µM -0.161995101755895 0.434059490915868 no 1916 0.435654855577917 2687 6502001
SGTC_2853 9015042 58.44 µM -0.162029094748063 0.43404669903047 no 1917 0.435641471150509 2665 6457456
SGTC_565 1418-0001 44.5 µM -0.162134057757575 0.434007200890288 no 1918 0.435600143398103 2835 2862145
SGTC_3246 9135460 32.98 µM -0.162488963209409 0.433873652958981 no 1919 0.435460409432437 2757 41446951
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.166636556685262 0.432313511957027 no 1920 0.433828013881355 2752 688788
SGTC_2879 9041815 71.43 µM -0.166733348568245 0.432277115638037 no 1921 0.433789932226474 2699 4942971
SGTC_3129 9127257 49.47 µM -0.167477711129539 0.431997234769972 no 1922 0.433497091886714 2735 837894
SGTC_838 0109-0203 71.4 µM -0.168993414681032 0.43142743476565 no 1923 0.432900910612587 2705 759422
SGTC_1564 D-Arginine 115 µM -0.169709144314706 0.431158419300852 no 1924 0.432619441136905 2740 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_724 3910-0327 137 µM -0.171531503502055 0.430473608449985 no 1925 0.431902930650739 2758 2885483
SGTC_2621 lithochol-11-enic acid 100 µM -0.17242906925713 0.430136395574866 no 1926 0.431550110229018 2716 6708711
SGTC_252 miconazole 1.30953 nM -0.173077003326858 0.429893000257617 no 1927 0.431295450415216 2779 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2705 st078069 42.8 µM -0.173849019566057 0.429603028476787 no 1928 0.430992059440425 2795 1530061
SGTC_2717 st081029 62.2815 µM -0.174638549297893 0.429306517849661 no 1929 0.430681828035826 2793 5292846
SGTC_3043 9092303 49.47 µM -0.174862034223393 0.429222594546285 no 1930 0.430594021442127 2742 25236084
SGTC_2342 7990637 118.86 µM -0.17677007023979 0.428506217406575 no 1931 0.429844499639989 2828 2033102 YER133W GLC7
SGTC_2455 5377712 9.75 µM -0.178328781925409 0.427921169671436 no 1932 0.429232388182569 2799 2243908
SGTC_1881 5652484 16 µM -0.178506013238519 0.427854657575922 no 1933 0.429162799578815 2827 2255129
SGTC_1668 st014914 51.6 µM -0.178709253625214 0.427778387211782 no 1934 0.429083001408872 2722 2839556
SGTC_517 1365-0151 113 µM -0.17962761162147 0.427433787137684 no 1935 0.428722463157372 2886 768657
SGTC_2905 7799065 20.05 µM -0.179924957149503 0.427322224535302 no 1936 0.428605740979422 2866 1296806
SGTC_1244 0416-0015 52.5 µM -0.180440425240325 0.427128837178983 no 1937 0.428403410184413 2752 96201
SGTC_1852 st056254 31.4 µM -0.183419222647008 0.426011630825862 no 1938 0.427234547112274 2759 442583
SGTC_1287 0971-0001 34.6 µM -0.183584524752363 0.425949651107684 no 1939 0.427169702116722 2725 4665869
SGTC_2769 toremifene 3.73 µM -0.18366736156767 0.425918592285183 no 1940 0.427137207487697 2908 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2378 9074213 121.43 µM -0.186450161920319 0.424875477784134 no 1941 0.426045879246468 2733 657714
SGTC_2694 st077685 81.9 µM -0.18700704271421 0.424666797568969 no 1942 0.425827555536104 2715 2838096
SGTC_878 0828-0289 13.7 µM -0.187377897437986 0.424527838702672 no 1943 0.425682175484845 2759 745350 YLR208W SEC13
SGTC_1752 st044819 83.042 µM -0.188288638095569 0.424186624993565 no 1944 0.425325195775673 2786 441209 YML126C ERG13
SGTC_1149 3909-7961 23.3 µM -0.191034645462004 0.42315816403344 no 1945 0.424249224910201 2751 735261
SGTC_2744 captopril 92.04 µM -0.192840528507872 0.422482092273239 no 1946 0.423541931002538 2823 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3095 9117207 49.47 µM -0.193441203061787 0.422257267134601 no 1947 0.423306724694503 2887 17015229
SGTC_2187 6125751 200 µM -0.196296063397952 0.421189075307523 no 1948 0.422189221204138 2801 874498
SGTC_324 1315-0088 19.6 µM -0.199867909663452 0.41985342907727 no 1949 0.42079194420409 2835 6787421
SGTC_1463 k081-0032 34.1 µM -0.201895354329662 0.419095701557768 no 1950 0.419999267000596 2831 977755
SGTC_3140 9094243 49.47 µM -0.202274301306213 0.418954108909053 no 1951 0.419851144651701 2719 19291112
SGTC_1270 0831-1170 17.3 µM -0.203715245248386 0.418415799583634 no 1952 0.419288014014957 2743 6764716
SGTC_2710 st078562 53.7235 µM -0.205577052761908 0.417720489947695 no 1953 0.4185606519486 2736 17250908
SGTC_448 monastrol 171 µM -0.205985543214162 0.417567969645718 no 1954 0.418401102000064 2798 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_3039 9090270 49.47 µM -0.207141897567932 0.417136282639859 no 1955 0.417949521042481 2817 17173750
SGTC_285 1486-1325 46 µM -0.208514688356938 0.416623925886185 no 1956 0.417413557516047 2885 22310230
SGTC_2100 5377183 190 µM -0.209307597939838 0.416328058450881 no 1957 0.417104060421358 2872 2844202
SGTC_192 3455-0609 60.9 µM -0.209674253577156 0.416191260051038 no 1958 0.416960960759 2900 3769639
SGTC_1492 4158-0558 28.5 µM -0.209946105049121 0.416089839426819 no 1959 0.41685486870339 2887 3967268
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.212061327386814 0.415300897060666 no 1960 0.416029594899561 2941 551469
SGTC_3178 9107506 49.47 µM -0.212351380391651 0.415192738711314 no 1961 0.415916456779164 2920 8897194
SGTC_681 1642-0006 26.6 µM -0.212611258709872 0.415095837709542 no 1962 0.415815094520114 2785 4446530
SGTC_2545 solidagenone 89.61 µM -0.21282557137123 0.415015930690158 no 1963 0.415731508783902 2724 6708572 An anti ulcer agent
SGTC_3162 9099653 49.47 µM -0.213358622060552 0.414817196642093 no 1964 0.415523626109286 2813 25237511
SGTC_560 2332-1943 155 µM -0.213536442047648 0.414750905943567 no 1965 0.415454283936765 2769 21177716
SGTC_1045 1348-1485 165 µM -0.213612154519289 0.414722681323237 no 1966 0.415424760117393 2778 6810614
SGTC_1337 1486-1011 40.3 µM -0.213893648470458 0.414617747917862 no 1967 0.415314996702957 2786 X1337
SGTC_1154 4088-0362 150 µM -0.214154527222289 0.414520504746195 no 1968 0.415213277708408 2760 6618304
SGTC_2965 9082772 38.63 µM -0.214419045994312 0.414421910097303 no 1969 0.415110145239164 2928 16459634
SGTC_1776 st049249 45.9 µM -0.215199475907614 0.414131050227532 no 1970 0.414805899760233 2821 1822314
SGTC_3356 9151811 4.48 µM -0.215217968860265 0.414124158625288 no 1971 0.414798691023025 2782 1859254 YPR165W RHO1
SGTC_1755 st041960 45.185 µM -0.215231531616382 0.414119104331826 no 1972 0.414793404143788 2915 2257073
SGTC_941 3237-0776 460 µM -0.217493447255753 0.413276379007902 no 1973 0.413911906559434 2969 760008
SGTC_733 4069-0007 56.1 µM -0.218901795597886 0.412751870045156 no 1974 0.41336327385269 2803 5717425 YNL287W SEC21
SGTC_1404 3909-7820 48.3 µM -0.222203028860678 0.411523008866784 no 1975 0.412077918182512 2881 23741373
SGTC_526 4469-0568 170 µM -0.222588512342548 0.411379571642795 no 1976 0.411927888994034 2771 2901964
SGTC_296 1222-0039 74.9 µM -0.222800073585208 0.41130085538467 no 1977 0.411845555367348 2835 5984176
SGTC_2001 4023502 57.655 µM -0.224315511883969 0.410737106060497 no 1978 0.411255903495665 2925 108941 YCR052W RSC6
SGTC_1018 4259-0013 28.1 µM -0.224712167348355 0.410589578977861 no 1979 0.411101599248483 2944 6801262
SGTC_3337 9144342 33.5465 µM -0.225136650595832 0.410431715988578 no 1980 0.410936484858614 2902 17682949
SGTC_636 0kpi-0074 126 µM -0.229297077818387 0.408885247852768 no 1981 0.409319012274259 2896 616434
SGTC_653 0203-0016 55.2 µM -0.229744828521535 0.408718898951062 no 1982 0.409145029179793 2861 295302
SGTC_1098 clofazimine 15.1 µM -0.230309466398019 0.408509147425581 no 1983 0.408925652597041 2917 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2920 7982904 15.77 µM -0.231739559604591 0.407978014161572 no 1984 0.408370151755572 2925 6456808
SGTC_24 0417-1663 219 µM -0.232239956681071 0.407792207736515 no 1985 0.408175822528165 2898 4329390
SGTC_1607 st000305 50.6 µM -0.233699437761109 0.407250394782797 no 1986 0.407609162135334 2962 5457690
SGTC_2420 aureobasidin a 50 nM -0.235073068618468 0.406740614626543 no 1987 0.407076010590205 3107 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2338 7999974 200 µM -0.23592656787924 0.406423944577923 no 1988 0.40674482595437 2893 315925
SGTC_3254 9136651 49.47 µM -0.236462318292149 0.406225198724089 no 1989 0.406536971945446 2832 16454030
SGTC_1333 1482-0047 286 µM -0.237111218251227 0.405984510452035 no 1990 0.406285254799097 2944 3811116
SGTC_1040 k898-0338 155 µM -0.2374710447927 0.405851059842308 no 1991 0.406145689859852 3057 20969351
SGTC_608 k048-0125 159 µM -0.237944855876868 0.405675351923547 no 1992 0.405961932239454 2935 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1294 1000-1494 117 µM -0.239283956028776 0.405178863401241 no 1993 0.405442702668863 2843 712797 YDL207W GLE1
SGTC_1743 st037606 46.3785 µM -0.239852305938764 0.404968186467175 no 1994 0.405222377988733 2840 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_988 1497-1057 103 µM -0.240244675648778 0.40482275824544 no 1995 0.405070290740928 2826 3533044
SGTC_363 0455-0021 3.06 µM -0.241942900553563 0.4041934786262 no 1996 0.404412203796396 2825 4597466
SGTC_2929 9013348 24.6 µM -0.244400424210574 0.403283278963267 no 1997 0.403460356632507 2939 2995952
SGTC_1780 st038448 24.544 µM -0.245494368597968 0.402878279981824 no 1998 0.403036834000136 3029 728868 YDL195W SEC31
SGTC_152 4469-0003 551.229 µM -0.245628768999454 0.402828529579043 no 1999 0.402984808465987 2842 697280
SGTC_426 0988-0037 14.6 µM -0.246136505183549 0.402640597324062 no 2000 0.402788282549893 2997 5383008
SGTC_1578 josamycin 24.2 µM -0.246778202753773 0.402403113108314 no 2001 0.402539940270045 2848 5282165 A P450 substrate.
SGTC_972 1319-0219 195 µM -0.249251493010115 0.401488117096371 no 2002 0.401583125159395 2941 23903702
SGTC_1205 4161-2785 76 µM -0.251039116547413 0.400827119932146 no 2003 0.400891933335074 2971 3498106
SGTC_1794 st048918 76.9 µM -0.2517166077319 0.400576682779558 no 2004 0.400630059570006 2863 672303
SGTC_2185 6113692 200 µM -0.252463699187863 0.400300565006652 no 2005 0.400341334670215 2986 874150
SGTC_1777 st045864 34.765 µM -0.253110816853164 0.400061436843214 no 2006 0.400091290172614 2858 4691462
SGTC_386 1509-0011 3.07 µM -0.253255173188822 0.400008098228476 no 2007 0.400035516862165 2843 3107280
SGTC_808 0711-0032 135 µM -0.254532984433655 0.399536037725028 no 2008 0.399541912539588 2879 4252555
SGTC_2311 7694451 200 µM -0.255455934700255 0.399195164435054 no 2009 0.399185486877323 2930 2163142
SGTC_3114 9122766 49.47 µM -0.255984549985913 0.39899996550731 no 2010 0.398981383635387 2907 17176985
SGTC_3192 9110362 49.47 µM -0.256801978680121 0.39869816774141 no 2011 0.398665821261005 2800 16649480
SGTC_1225 1216-0074 20.6 µM -0.257025816805346 0.398615536414166 no 2012 0.398579421731972 2884 4241466
SGTC_1180 1193-0155 285 µM -0.257651441535623 0.398384607013239 no 2013 0.398337962514887 3002 2921347
SGTC_2677 mitomycin C 100 µM -0.258965406781694 0.39789971461018 no 2014 0.397830965797798 2886 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3156 9099931 49.47 µM -0.259782667114316 0.397598200630899 no 2015 0.397515710845448 2841 18111053
SGTC_661 1304-0007 33.6 µM -0.26049116566512 0.397336861908806 no 2016 0.397242464472465 2878 3117130
SGTC_1310 1188-0297 994 nM -0.262104062092337 0.39674209653278 no 2017 0.396620607568036 2915 1588352
SGTC_75 0159-0059 199.013 µM -0.262224639429777 0.396697642535964 no 2018 0.396574129165441 3176 5377270
SGTC_1284 0929-0043 16 µM -0.263654836061962 0.396170465606199 no 2019 0.396022949981809 2933 1239883
SGTC_2102 5377816 72.7585 µM -0.264005682869207 0.39604117084686 no 2020 0.395887769884878 3059 1379702
SGTC_1730 st033808 45.1 µM -0.264111349192363 0.396002232724545 no 2021 0.395847059457901 2861 1045166
SGTC_2206 7254556 146.969 µM -0.26411229245306 0.396001885136916 no 2022 0.39584669604973 2911 4398905
SGTC_1941 st076221 61.8 µM -0.264258466728663 0.39594802152609 no 2023 0.395790380871919 3027 2828568
SGTC_2323 6148992 148.28 µM -0.265446241398986 0.395510413387856 no 2024 0.395332858932813 2921 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_718 1130-0073 349 µM -0.265549448503365 0.395472395326059 no 2025 0.395293111128383 3043 6740020
SGTC_512 prima-1 270 µM -0.266284173024914 0.395201776035886 no 2026 0.395010180652525 3029 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1685 st024049 53.0905 µM -0.266294592268845 0.39519793870431 no 2027 0.395006168768658 2965 1941139
SGTC_2135 5326629 150.42 µM -0.26816244722813 0.39451018590501 no 2028 0.394287139717556 2928 5020077
SGTC_787 4152-0075 138 µM -0.268765077585231 0.394288364658314 no 2029 0.394055234426715 2892 9566539
SGTC_2891 9063876 19.48 µM -0.269466771693498 0.394030122393701 no 2030 0.393785254577636 2993 6472478
SGTC_789 1309-1135 70.6 µM -0.269634410380568 0.39396843374757 no 2031 0.393720762415682 2862 3092424
SGTC_2746 daunorubicin 9.88 µM -0.270013741989681 0.39382885494792 no 2032 0.393574840781445 2891 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1489 4065-0444 182 µM -0.271322939933538 0.393347227547155 no 2033 0.393071332229352 3007 2877968
SGTC_3224 9130643 49.47 µM -0.27283918942291 0.392789634024909 no 2034 0.392488416605294 3086 17644395
SGTC_2414 st077232 92.9 µM -0.273195113013257 0.39265877665344 no 2035 0.392351618199244 2851 729801
SGTC_611 3453-1652 23.7 µM -0.273458399947844 0.392561985491721 no 2036 0.392250433034798 2987 1560575
SGTC_602 3130-1533 38.1 µM -0.274207020333884 0.392286809388478 no 2037 0.391962766686426 3004 720941
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.274920121092716 0.392024739582595 no 2038 0.391688804087395 3099 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_3270 9137563 49.47 µM -0.275281895440658 0.391891803551171 no 2039 0.391549836343399 2996 17015724
SGTC_3126 9127922 49.47 µM -0.276110150447876 0.391587504104859 no 2040 0.39123173234174 3131 45595682
SGTC_1678 st019265 80.2 µM -0.276286668682865 0.391522660180557 no 2041 0.391163947210321 3120 5367020
SGTC_2512 diallyl trisulfide 49.23 µM -0.276860370139507 0.391311931937018 no 2042 0.390943661772741 2907 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2375 9072683 200 µM -0.278121575643613 0.390848786451034 no 2043 0.390459516952446 3068 16798029
SGTC_1335 1486-0900 202 µM -0.278895921459846 0.390564504388315 no 2044 0.390162349305599 2858 X1335
SGTC_649 1123-0311 367 µM -0.281140547039236 0.389740776209428 no 2045 0.389301301372717 2996 693629 YIL048W NEO1
SGTC_538 2922-0838 53.3 µM -0.281594297800492 0.389574319696278 no 2046 0.389127306521342 3104 777039
SGTC_26 0302-0163 425.158 µM -0.282750530765297 0.38915025224579 no 2047 0.388684039061178 2909 3100915
SGTC_1993 st073995 70.8 µM -0.283755924804644 0.388781614725603 no 2048 0.388298716788845 2933 3098394
SGTC_2179 6298986 200 µM -0.283928231831197 0.3887184467164 no 2049 0.388232690285545 3051 738374
SGTC_2842 9000675 19.48 µM -0.284259968939413 0.388596839691541 no 2050 0.388105580705915 2967 2989072
SGTC_375 3970-0961 9.27 µM -0.284825272152275 0.388389637982563 no 2051 0.38788900472213 2944 2898222
SGTC_986 1493-0483 84 µM -0.284915397070612 0.388356607250972 no 2052 0.387854479760007 3012 40079
SGTC_1972 st070201 17.4 µM -0.286886752311321 0.387634309047975 no 2053 0.387099517221228 3046 2829099
SGTC_2124 5246320 200 µM -0.287654839927132 0.387352989311179 no 2054 0.386805480988941 3005 579342
SGTC_3083 9117465 49.47 µM -0.287840288978828 0.387285075607807 no 2055 0.386734497853101 3015 16420915
SGTC_688 0527-0193 473 µM -0.290960038790171 0.386143103887104 no 2056 0.385540941147454 2935 4007154
SGTC_2748 diazoxide 86.69 µM -0.291855455582637 0.385815521837831 no 2057 0.385198571327253 3001 3019 A potassium channel activatior.
SGTC_2195 6536160 144.242 µM -0.293409779733974 0.385247076521125 no 2058 0.384604475547902 2902 3834386
SGTC_3145 9085516 49.47 µM -0.294617447468406 0.384805579994833 no 2059 0.38414306615858 3013 25236195
SGTC_1082 camptothecin 424.86 nM -0.298237891599833 0.383482922918907 no 2060 0.382760801800635 2787 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_219 mitoxanthrone 164.414 µM -0.298926031425808 0.3832316777272 no 2061 0.382498242252153 2977 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_195 4234-0266 16.654 µM -0.299113835509205 0.383163117523816 no 2062 0.382426595034931 2970 2303354
SGTC_204 PMA1.184 62.41 µM -0.300208868942479 0.382763434964456 no 2063 0.382008920237662 2937 2252213 YGL008C PMA1
SGTC_2948 9070189 9.45 µM -0.300990275885579 0.382478301030123 no 2064 0.381710954811487 3072 6473636 YDL196W YDL196W
SGTC_2250 alverine citrate 130 µM -0.302327404111914 0.381990533279752 no 2065 0.38120124485574 2885 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2919 7978188 46.38 µM -0.302682263593004 0.381861116364782 no 2066 0.381066007860721 3109 2980291
SGTC_149 3970-0822 46.1 µM -0.302777997110514 0.381826204702704 no 2067 0.381029526291767 2958 3114250 YBL034C STU1
SGTC_2158 5657123 3.6195 µM -0.302834482063033 0.381805606478921 no 2068 0.381008001832413 2916 2858827
SGTC_1201 1889-3372 45.9 µM -0.302960915448955 0.381759501550982 no 2069 0.38095982378188 2966 5392199
SGTC_1153 4055-0057 267 µM -0.303452278633676 0.381580338034484 no 2070 0.380772605002628 2929 882706
SGTC_2371 9071574 200 µM -0.304503343896267 0.381197178119308 no 2071 0.380372222785053 3053 45596039
SGTC_1878 temozolomide 1 mM -0.305083238430108 0.380985830652434 no 2072 0.380151378418936 3041 5394 DNA alkylating agent.
SGTC_3168 9103419 49.47 µM -0.309427724844532 0.379403579131885 no 2073 0.378498091564695 3023 16649256
SGTC_9 0092-0002 10.449 µM -0.310456854056896 0.379029067348277 no 2074 0.378106782531409 3005 759368
SGTC_416 estradiol valerate 100 µM -0.312391592794155 0.37832530158221 no 2075 0.377371469442858 3022 13791 A steroid.
SGTC_1690 st023502 41.2 µM -0.313253346834864 0.378011966251405 no 2076 0.377044095725646 3045 24207482
SGTC_2332 7982454 138.89 µM -0.31338859915874 0.37796279554022 no 2077 0.376992722427318 3040 2981748
SGTC_2190 6049624 200 µM -0.313658613943666 0.377864638120214 no 2078 0.376890168410346 3030 2265554
SGTC_2985 9022375 71.43 µM -0.314151237110806 0.377685577064693 no 2079 0.37670308813186 3155 4939335
SGTC_1550 gossypolone 36.6 µM -0.314900729876766 0.377413198225926 no 2080 0.376418513708117 2959 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1387 3342-1166 1.8 µM -0.316699411927355 0.376759774511513 no 2081 0.375735847528098 3019 3418228
SGTC_1017 4239-0030 168 µM -0.317345532354571 0.37652513847129 no 2082 0.37549071579958 2977 1149593
SGTC_1256 0570-0116 285 µM -0.317896342974439 0.376325149817542 no 2083 0.375281783353988 2995 410638
SGTC_2222 6885208 172.143 µM -0.318808979562488 0.375993862267534 no 2084 0.374935684310508 3008 609514
SGTC_2493 resveratrol 26.09 µM -0.31882149780351 0.3759893187743 no 2085 0.374930937719153 2918 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_191 3914-0123 66.505 µM -0.321301715198187 0.375089464200812 no 2086 0.373990878365718 2941 3144412
SGTC_34 0469-0683 81.75 µM -0.321448329084606 0.375036292030661 no 2087 0.373935331726078 3042 3690923
SGTC_1436 4092-1007 8.32 µM -0.321629264553666 0.37497067579354 no 2088 0.373866785502819 2993 2881121
SGTC_2499 avocadenofuran 51.48 µM -0.321829663372192 0.374898005397488 no 2089 0.373790870372125 2949 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_882 0843-0131 351 µM -0.32213104723621 0.374788723272449 no 2090 0.373676709280336 3029 5425421
SGTC_2161 5662504 8.5105 µM -0.3231998826375 0.37440124347194 no 2091 0.373271934891325 3005 2859334
SGTC_909 3448-9333 149 µM -0.324697867278222 0.373858399733907 no 2092 0.372704874472315 2956 3344074
SGTC_1251 0490-5699 265 µM -0.326090671364592 0.373353895953269 no 2093 0.372177877395522 3156 3883818
SGTC_2383 9036125 200 µM -0.326815861026815 0.373091302421133 no 2094 0.371903581124474 2976 79580
SGTC_2393 9031399 185.94 µM -0.326830422803857 0.373086030157647 no 2095 0.371898073932506 3116 1526623 YDL150W RPC53
SGTC_1951 sophoraflavanone G 9.2 µM -0.327280471143777 0.372923096559458 no 2096 0.371727880806836 2992 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1796 st049173 110.4 µM -0.328392616850181 0.372520557567597 no 2097 0.371307412326856 3095 94134
SGTC_2465 5809242 33.21 µM -0.328412029793649 0.372513532325122 no 2098 0.37130007424518 2941 2731748
SGTC_1394 3474-0001 65.7 µM -0.32891360716702 0.372332033982392 no 2099 0.371110494507997 3018 5017666 YIL048W NEO1
SGTC_2549 cedrol 20.94 µM -0.328989544255498 0.372304558228082 no 2100 0.371081795512808 3143 6708665 A sedative which affects the nervous system.
SGTC_1140 3229-1848 2.98 µM -0.329103104917061 0.372263470627867 no 2101 0.371038878733235 3103 2849525
SGTC_2731 amoxapine 43.43 µM -0.329108496735821 0.372261519839762 no 2102 0.371036841100086 3043 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_73 0327-0325 16.231 µM -0.329171177970164 0.372238841683336 no 2103 0.371013153373215 3100 53298
SGTC_110 0850-0284 111.64 µM -0.329306396288392 0.372189921019629 no 2104 0.370962054981628 2898 3906265
SGTC_2219 9098279 200 µM -0.33076593633852 0.371662005165638 no 2105 0.370410646388276 3075 902349
SGTC_1051 3253-3903 78 µM -0.331820952119042 0.371280555962884 no 2106 0.370012231157017 2932 5509239
SGTC_944 3370-0224 231 µM -0.332174807359618 0.371152645123622 no 2107 0.369878632785651 3015 4580514
SGTC_2082 5219693 150 µM -0.332283016330475 0.371113532816054 no 2108 0.36983778152365 2980 2834649
SGTC_2409 alverine citrate 63.97 µM -0.332708026392797 0.370959925127872 no 2109 0.369677345112969 3222 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3342 9147791 14.508 µM -0.33306599372887 0.370830564058525 no 2110 0.36954223415881 2981 1838168
SGTC_3260 9137109 49.47 µM -0.333092064583054 0.370821143228357 no 2111 0.369532394621985 3056 17478346
SGTC_1246 0422-0085 105 µM -0.333722664963788 0.370593296310526 no 2112 0.369294422491622 3139 264295
SGTC_180 1486-1293 102.781 µM -0.333760862657899 0.370579496274237 no 2113 0.369280009286128 3133 4140536
SGTC_2536 dehydroabietamide 32.04 µM -0.334243741091932 0.370405056654259 no 2114 0.369097819737347 3140 3983547
SGTC_140 0062-0056 502.533 µM -0.33492375988812 0.370159445356074 no 2115 0.368841299195679 2948 3758964
SGTC_1103 duloxetine 36.1 µM -0.334968357243073 0.370143339393695 no 2116 0.368824477968912 3144 60835 A selective serotonin reuptake inhibitor.
SGTC_1058 3448-5425 97.3 µM -0.335977670576151 0.369778895251057 no 2117 0.368443852500929 2995 7279705
SGTC_2235 salicylic acid 500 µM -0.336017086671377 0.369764665207619 no 2118 0.368428990783766 3042 338 A COX inhibitor and kinase inhibitor.
SGTC_1697 st025554 27.742 µM -0.336373102163907 0.369636144172835 no 2119 0.368294765160518 2973 1269519
SGTC_1015 4130-4525 82 µM -0.337371349392794 0.369275856194549 no 2120 0.367918489899885 3013 1363237
SGTC_1378 2093-0007 380 nM -0.33883769238026 0.368746831046775 no 2121 0.367366002365773 3118 3618014
SGTC_586 0957-0265 8.15 µM -0.339095568232613 0.368653820639797 no 2122 0.367268868454718 3100 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_3020 9089140 49.47 µM -0.339411459539298 0.368539895761526 no 2123 0.367149893479585 3093 17217859
SGTC_983 1491-0821 12.2 µM -0.339749363170286 0.368418045020735 no 2124 0.367022642064725 3129 46495113
SGTC_3049 9092223 49.47 µM -0.339989888099129 0.368331317876378 no 2125 0.366932071476972 3101 8623917
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.340141386047965 0.36827669502966 no 2126 0.366875028142493 3107 140250 A respiratory chain inhibitor.
SGTC_2033 5192550 145 µM -0.341195194935384 0.367896816144212 no 2127 0.36647832018948 3038 182073
SGTC_495 decylubiquinone 155 µM -0.341867765787642 0.367654434120403 no 2128 0.366225204403394 3069 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_962 1254-0300 21.5 µM -0.34236498618478 0.367475279016222 no 2129 0.366038117537377 2956 7340576
SGTC_1997 st073024 93.8 µM -0.344084179715044 0.366856053256431 no 2130 0.365391490044792 3147 686268
SGTC_2291 7917025 104.35 µM -0.344501547493803 0.366705776297105 no 2131 0.365234566224114 2968 2964612
SGTC_1716 st033144 30.6155 µM -0.344779039997651 0.366605873972321 no 2132 0.365130245825672 3177 674617
SGTC_2140 5586273 200 µM -0.345920949979609 0.366194860880737 no 2133 0.364701061851327 3036 854421
SGTC_2357 9067248 200 µM -0.346059798902616 0.366144894782983 no 2134 0.364648887383471 3109 9150235
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.346256211721118 0.366074217649495 no 2135 0.364575086740481 3133 521171
SGTC_2321 7390090 138.78 µM -0.346421078176358 0.366014895658193 no 2136 0.364513143281236 3068 649046
SGTC_880 0833-0487 87.2 µM -0.346503797505921 0.36598513292431 no 2137 0.364482065390363 3003 76075
SGTC_758 0868-0029 16 µM -0.348116050304952 0.36540519938372 no 2138 0.363876515464267 3127 762687
SGTC_1342 1486-1464 234 µM -0.348767465537826 0.365170969986783 no 2139 0.3636319451383 3018 3253938
SGTC_141 0443-0274 32.331 µM -0.34887571182963 0.365132052734563 no 2140 0.363591310034184 3163 1627241
SGTC_1965 Pectolinarigenin 58.4 µM -0.352347405790339 0.363884630506337 no 2141 0.362288870016756 3034 5320438 An anti-inflammatory.
SGTC_2640 pentamidine 10.38 µM -0.354553355973209 0.363092753426094 no 2142 0.361462112601909 3137 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_450 aminopyrene 156 nM -0.355198442314516 0.362861295074525 no 2143 0.361220465798487 3148 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1059 3448-6867 171 µM -0.356066837469305 0.362549792160638 no 2144 0.36089525583651 3068 3934407
SGTC_2070 5230947 200 µM -0.357572294400606 0.362009983805335 no 2145 0.360331707548392 3136 2835538
SGTC_1423 4048-0112 5.59 µM -0.359405042918545 0.361353189629957 no 2146 0.359646051356911 3117 X1423
SGTC_3034 9090421 49.47 µM -0.359509478790158 0.36131577567899 no 2147 0.359606994052191 3084 17173761
SGTC_2686 alizarin 95.37 µM -0.361483385070359 0.360608877344826 no 2148 0.358869061646947 3083 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_3264 9137442 49.47 µM -0.362645053827402 0.360193081118478 no 2149 0.358435024986147 3273 17015726
SGTC_2785 7756463 72.73 µM -0.362858303041248 0.360116770749657 no 2150 0.358355368093056 3016 2201551
SGTC_3090 9117696 49.47 µM -0.36437337281629 0.359574769788457 no 2151 0.357789608116813 3081 7923821
SGTC_2295 7971645 200 µM -0.365761119721636 0.359078565015539 no 2152 0.357271667223754 3072 2978226 YKL099C UTP11
SGTC_2836 9010338 19.48 µM -0.366005955169433 0.358991045940795 no 2153 0.35718031593173 3035 2994051
SGTC_2094 5332512 191.667 µM -0.367107862703397 0.358597248860902 no 2154 0.356769281281539 3197 755774
SGTC_2170 morpholine 200 µM -0.367457846440149 0.35847220393892 no 2155 0.35663876476246 3154 121171 Reacts with secondary amines.
SGTC_792 4534-1957 155 µM -0.367547286676099 0.358440250466872 no 2156 0.356605413252558 3059 1717904
SGTC_1179 1021-1431 9.29 µM -0.368174149374703 0.358216324953378 no 2157 0.356371692220406 3134 2840958
SGTC_3139 9095020 49.47 µM -0.368456628955226 0.358115434601605 no 2158 0.356266389461671 2940 25236292
SGTC_2607 solasodine 47.35 µM -0.369821257271757 0.357628183866487 no 2159 0.355757837704118 3068 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1717 st033143 58.0435 µM -0.3726483197445 0.356619498836321 no 2160 0.354705102511379 3235 674616
SGTC_2236 dapsone 200 µM -0.373371340359394 0.356361688467231 no 2161 0.354436043422663 3119 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2872 9044037 25.97 µM -0.374420347068566 0.355987756640381 no 2162 0.35404580363883 3046 6465195
SGTC_2877 9040724 71.43 µM -0.374479608581977 0.355966636247183 no 2163 0.354023762400814 3235 6463895
SGTC_744 1594-0068 283 µM -0.374802890206781 0.355851428697633 no 2164 0.353903532316419 3067 668392
SGTC_3105 9121040 49.47 µM -0.3751311583772 0.355734457567054 no 2165 0.353781462616139 3112 41448907
SGTC_1451 4152-0210 104 µM -0.375436939607691 0.355625511380406 no 2166 0.353667768424104 3218 659563
SGTC_1986 st071812 45 µM -0.375960183236123 0.355439113308709 no 2167 0.353473248628102 3150 11838594
SGTC_81 0411-0046 9.971 µM -0.376260924183538 0.355331994283423 no 2168 0.353361463207783 3121 12925265
SGTC_3044 9093193 49.47 µM -0.377081759596311 0.355039684271236 no 2169 0.353056423056801 3157 25236277
SGTC_1903 st060211 78.3 µM -0.377816776418592 0.354778007737101 no 2170 0.352783355053928 3225 688960
SGTC_63 0099-0242 26.702 µM -0.379157434382246 0.354300890767932 no 2171 0.352285479104608 3192 3898502 YLR359W ADE13
SGTC_2243 6634756 200 µM -0.380386138475727 0.353863816966487 no 2172 0.351829401300272 3299 885676
SGTC_2353 9059630 146.67 µM -0.380771294198405 0.353726849235929 no 2173 0.351686480717774 3170 4779114
SGTC_2788 5282734 71.43 µM -0.382161982776961 0.35323245513649 no 2174 0.35117060943441 3228 743706
SGTC_2643 anethole 100 µM -0.382883760696956 0.352975958393009 no 2175 0.350902976317435 3134 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1223 0764-0573 147 µM -0.382997839210516 0.352935424654965 no 2176 0.350860683106932 3077 1609797
SGTC_1260 0700-1617 7.75 µM -0.383103731734058 0.352897801010619 no 2177 0.350821426405563 3176 2853078
SGTC_2802 7925815 54.55 µM -0.384081996641678 0.352550291271104 no 2178 0.350458837322638 3055 1262923
SGTC_1602 st001878 87.6 µM -0.384242616710438 0.352493245840132 no 2179 0.350399317293398 3228 595405 YLR310C CDC25
SGTC_3133 9127736 49.47 µM -0.385115185338712 0.352183404493067 no 2180 0.350076038910253 3280 27243420
SGTC_3092 9117248 49.47 µM -0.385928017039977 0.351894863440386 no 2181 0.349774990203091 3137 17141857
SGTC_418 lividomycin a 100 µM -0.386378946899926 0.351734827982301 no 2182 0.349608019893456 3222 72394 An antibiotic.
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.387012589581871 0.351509991956685 no 2183 0.349373443842507 3092 88881 An O-methylated flavonoid and antioxidant.
SGTC_786 4544-0069 423 µM -0.387708328834854 0.35126318197223 no 2184 0.349115945742723 3170 748821 YLR208W SEC13
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.388079451069938 0.351131553876056 no 2185 0.348978619131793 3047 23665772 A membrane-active detergent.
SGTC_177 1327-0068 8.361 µM -0.388133044440768 0.351112547076693 no 2186 0.348958789574467 3190 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1824 st053723 68.6 µM -0.390455171816294 0.350289366741959 no 2187 0.348099998784568 3135 675225
SGTC_1587 estradiol valerate 56.1 µM -0.393247776972489 0.34930033580091 no 2188 0.347068242675553 3234 13791 A steroid.
SGTC_682 0kpi-0099 17 µM -0.393574516180891 0.349184684305999 no 2189 0.346947599452186 3187 1714895 YML126C ERG13
SGTC_1503 4585-0012 61.3 µM -0.393605259938835 0.349173803071048 no 2190 0.346936248609953 3255 2922052
SGTC_2861 9024595 19.48 µM -0.393631204183741 0.349164620639309 no 2191 0.346926669893326 3126 16482810
SGTC_262 fenpropimorph 62.5 µM -0.393819811870758 0.349097869483325 no 2192 0.346857038138877 3147 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2372 9071633 200 µM -0.39409161126717 0.349001683716289 no 2193 0.346756702074655 3228 21321366
SGTC_1822 st052468 42 µM -0.394502137916309 0.348856422829531 no 2194 0.346605174549336 3152 2873678
SGTC_2745 rifampicin 24.3 µM -0.394688830340664 0.348790370845413 no 2195 0.346536273518401 3139 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_1750 st081859 2.357 µM -0.395829476061958 0.348386908737892 no 2196 0.346115415164647 3157 5291695
SGTC_269 exalamide 29 µM -0.397221447753025 0.347894781518474 no 2197 0.34560208374355 3105 3316 A derivative of salicylamide.
SGTC_1760 st045453 10.4495 µM -0.398001943316823 0.347618951773078 no 2198 0.345314376637042 3230 3323419 YIL048W NEO1
SGTC_2116 5511452 16.8835 µM -0.398202368635463 0.347548133803022 no 2199 0.345240510056236 3224 870744
SGTC_403 arphamenine a 50 µM -0.400342270296968 0.346792356364314 no 2200 0.344452219089949 3126 5487158 An arginine aminopeptidase inhibitor.
SGTC_2804 7954240 19.48 µM -0.400700002691543 0.34666607062833 no 2201 0.34432050440868 3226 828705
SGTC_2641 levomentholum 100 µM -0.400796097054361 0.346632150554891 no 2202 0.344285126321529 3159 16666
SGTC_2902 5787006 60.46 µM -0.401250231367272 0.346471863626437 no 2203 0.344117950736377 3070 591003
SGTC_818 4072-2707 53.5 µM -0.406007998714617 0.344794264550781 no 2204 0.342368361637801 3056 882871
SGTC_2228 7354201 200 µM -0.406584188139499 0.344591305116932 no 2205 0.342156706198371 3150 753451
SGTC_2855 9016525 58.44 µM -0.408122316209755 0.344049727496044 no 2206 0.34159193851552 3086 43811474
SGTC_2060 5238662 140 µM -0.409094589738211 0.343707553123407 no 2207 0.341235123254106 3206 790130
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.40981583757909 0.343453805454938 no 2208 0.340970523721042 3132 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_1502 4534-4282 27.7 µM -0.409933648247442 0.343412364290073 no 2209 0.340927310709446 3165 3278949
SGTC_1985 st071382 65.5 µM -0.410610268751812 0.343174392243297 no 2210 0.340679166399502 3152 6123237
SGTC_2134 5324836 1.464 µM -0.410789458703954 0.343111380324776 no 2211 0.340613461683421 3105 699272
SGTC_1200 1643-0193 18.4 µM -0.410971989819507 0.343047197975431 no 2212 0.340546536814184 3240 5403974
SGTC_1774 st048371 48.465 µM -0.41306139575215 0.342312835359345 no 2213 0.339780816100273 3105 4242727
SGTC_898 1000-0849 28.3 µM -0.414867063617819 0.34167867785629 no 2214 0.339119611070136 3214 6751807
SGTC_3155 9099265 49.47 µM -0.415739670820036 0.341372374785694 no 2215 0.338800254417521 3222 25236499
SGTC_2789 5281112 71.43 µM -0.415849863848908 0.341333702191525 no 2216 0.338759934222606 3156 765948
SGTC_754 3474-0146 171 µM -0.415863365154466 0.341328963979942 no 2217 0.338754994152643 3100 24762078
SGTC_2956 9076196 2.52 µM -0.416635717837228 0.341057952565381 no 2218 0.338472439810259 3267 16423868
SGTC_2889 9059656 51.95 µM -0.417141882162801 0.34088038864288 no 2219 0.338287316028328 3218 3949838
SGTC_542 3381-0244 89.3 µM -0.41901478775865 0.340223674633455 no 2220 0.337602662510001 3291 1112843
SGTC_2227 7312221 64.1025 µM -0.420416934889623 0.339732343863296 no 2221 0.337090449433809 3171 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3173 9105693 49.47 µM -0.421692986698158 0.339285435078625 no 2222 0.336624562097949 3313 17096658
SGTC_1867 st057372 64 µM -0.421922934896269 0.33920492484534 no 2223 0.336540634496051 3219 688837
SGTC_981 1488-1094 54.9 µM -0.421977170718601 0.339185936687359 no 2224 0.336520840430722 3117 3449522
SGTC_1159 4092-0538 61.2 µM -0.422440736129008 0.339023657425271 no 2225 0.336351674722409 3168 717301
SGTC_1288 0973-0013 65.5 µM -0.423674094051393 0.338592044190313 no 2226 0.335901755359415 3265 4315430
SGTC_162 k030-0015 37.8 µM -0.424221546359099 0.338400531290309 no 2227 0.335702124306379 3207 1809920 YMR134W ERG29
SGTC_999 SEC7.066 22.7 µM -0.425740885430394 0.337869246466437 no 2228 0.335148333190325 3130 740511 YDR170C SEC7
SGTC_2706 st078239 82.5 µM -0.428225629857783 0.337001073285699 no 2229 0.33424342907116 3219 15434492
SGTC_1326 1431-2094 10.8 µM -0.42869148318881 0.336838399917287 no 2230 0.334073879737861 3084 616278
SGTC_830 4076-0286 57.8 µM -0.430647340821093 0.336155758740358 no 2231 0.33336240671721 3160 6866659
SGTC_556 4058-0063 51.5 µM -0.431045977302552 0.336016691225158 no 2232 0.333217470035793 3210 6615692
SGTC_3045 9092950 49.47 µM -0.431658480201738 0.335803058446177 no 2233 0.332994824104584 3306 44120432
SGTC_74 000s-0487 160.283 µM -0.432553220072622 0.335491080564361 no 2234 0.332669690322186 3245 677548
SGTC_272 doxorubicin 8.13 µM -0.433148851787438 0.335283458560913 no 2235 0.332453317273979 3236 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2074 5212007 75.395 µM -0.434192632285805 0.334919744681664 no 2236 0.332074281432401 3261 758611
SGTC_887 0885-0007 9.62 µM -0.435678426169869 0.334402274641258 no 2237 0.331535030267564 3275 5719458
SGTC_939 1165-0479 45.3 µM -0.436107470179518 0.3342529063196 no 2238 0.331379378752643 3282 1377347
SGTC_368 fentichlor 4.58 µM -0.436907434120448 0.333974475214351 no 2239 0.331089240158361 3213 7329 A pesticide.
SGTC_427 1354-0053 47.3 µM -0.437289957090996 0.333841368626537 no 2240 0.330950538881639 3345 6813657
SGTC_2894 9048625 32.47 µM -0.43814987195427 0.333542220234159 no 2241 0.330638821961641 3326 4092861
SGTC_3164 9100705 49.47 µM -0.442401021946038 0.332064881865577 no 2242 0.329099519821774 3304 17174235
SGTC_2333 9017922 200 µM -0.443042212132964 0.331842284323822 no 2243 0.328867601243509 3290 3163164
SGTC_2624 nerol 100 µM -0.443254112910255 0.331768733247302 no 2244 0.328790971181684 3195 637566 A natural product oil.
SGTC_3069 9117009 49.47 µM -0.447972061059845 0.330132810230646 no 2245 0.327086680157154 3200 41904981
SGTC_550 4123-0385 25.7 µM -0.44915005991034 0.329724850129415 no 2246 0.32666170517719 3191 5731123
SGTC_1034 k072-0165 12.7 µM -0.451938992177967 0.328759805599181 no 2247 0.325656466657549 3331 5835461
SGTC_700 3453-2283 142 µM -0.453541497615622 0.328205811792304 no 2248 0.325079434441259 3354 565664
SGTC_2531 methyl deoxycholate 70.07 µM -0.453650723556575 0.328168065594559 no 2249 0.325040119472129 3149 16667744 Haematoxylin.
SGTC_367 0335-0881 7.1 µM -0.453787271532811 0.328120879941332 no 2250 0.324990972903547 3336 23828853
SGTC_1636 st007707 68.9 µM -0.455236415081751 0.327620281601421 no 2251 0.324469582605134 3390 403051
SGTC_3335 9143315 29.6265 µM -0.455348520147822 0.327581568443252 no 2252 0.324429262413671 3208 4899691
SGTC_197 4544-0043 41.561 µM -0.457565403262607 0.326816395077343 no 2253 0.323632351965191 3266 896523
SGTC_3047 9092122 49.47 µM -0.457682303710379 0.326776066207263 no 2254 0.323590351765637 3251 17173831
SGTC_2875 9039966 71.43 µM -0.459164761721124 0.326264816505918 no 2255 0.323057926716975 3247 6463691
SGTC_2589 lobaric acid 100 µM -0.459776580328571 0.326053915992134 no 2256 0.322838297521057 3191 73157 A novel microtubule depolymerizer.
SGTC_1443 4112-3303 14 µM -0.460288662174717 0.325877438583821 no 2257 0.3226545190777 3223 704433
SGTC_428 3448-4153 16.5 µM -0.460974680695912 0.325641078970888 no 2258 0.322408385273108 3131 3834874
SGTC_395 anisomycin 6.25 µM -0.461211514172954 0.325559497050574 no 2259 0.322323430816492 3262 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_351 caspofungin 25 nM -0.461468845154942 0.325470863835762 no 2260 0.322231134225402 3226 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2582 agaric acid 100 µM -0.461761353915021 0.325370126227344 no 2261 0.322126233772889 3305 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1197 1601-0112 267 µM -0.462939593992969 0.324964479301877 no 2262 0.321703832990053 3197 7350313
SGTC_2713 st079149 53.4 µM -0.46384735341715 0.324652095443227 no 2263 0.321378556982395 3274 3103253
SGTC_114 0364-0001 490.298 µM -0.464313267152218 0.324491810160213 no 2264 0.321211660009776 3292 4003655
SGTC_147 4466-0538 29.23 µM -0.465186957781719 0.324191327683954 no 2265 0.320898788857878 3402 6742687 YHR072W ERG7
SGTC_1549 4'-methoxyflavonol 74.6 µM -0.467336163874082 0.323452653326663 no 2266 0.320129693327781 3284 97141
SGTC_1736 st036774 51 µM -0.468783762275973 0.322955510635622 no 2267 0.319612103794259 3424 1272247
SGTC_2147 5545932 89.7195 µM -0.46888069374365 0.32292223314941 no 2268 0.319577458432827 3279 797404
SGTC_3294 9122953 26.2835 µM -0.469023982811315 0.322873043259056 no 2269 0.319526246766685 3247 16459826
SGTC_864 0469-0573 172 µM -0.469198203436182 0.3228132390083 no 2270 0.319463984765181 3227 689425
SGTC_1092 toremifene 6.32 µM -0.4699888398709 0.322541896939262 no 2271 0.319181495473758 3268 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3100 9120536 49.47 µM -0.471280863977867 0.322098684802415 no 2272 0.318720089554976 3259 16421196
SGTC_2982 9019404 25.97 µM -0.471584702931403 0.321994493487837 no 2273 0.31861162376407 3196 22333232
SGTC_582 0987-0078 156 µM -0.472023873406337 0.321843919522609 no 2274 0.318454874187114 3367 1625765
SGTC_3258 9138477 49.47 µM -0.472627399739271 0.3216370422388 no 2275 0.318239515408558 3272 4970355
SGTC_921 1561-0023 372 µM -0.472899023457953 0.321543952862599 no 2276 0.318142610840611 3223 24050882
SGTC_1008 4106-0037 6 µM -0.473283329601313 0.321412264732736 no 2277 0.318005526917648 3217 2905394
SGTC_2447 5741742 33.78 µM -0.475754956318054 0.320565862578181 no 2278 0.317124481776045 3331 1776504
SGTC_2352 9027995 87.8 µM -0.475932657401697 0.320505045173578 no 2279 0.317061177642061 3277 2997347
SGTC_610 4215-0184 155 µM -0.476355011722287 0.320360515629634 no 2280 0.316910739863164 3300 5605015
SGTC_462 ag-879 158 µM -0.476954769939241 0.320155325330478 no 2281 0.316697164851212 3319 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2642 cholecalciferol 100 µM -0.477486662653094 0.319973399296842 no 2282 0.316507807977564 3317 9821465 A vitamin D precursor, similar to steriods.
SGTC_1803 st050068 52.4 µM -0.477521182449144 0.319961593806628 no 2283 0.316495520392272 3375 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2226 7298446 200 µM -0.480422652004809 0.318969967444688 no 2284 0.315463445226226 3325 3283010
SGTC_2696 st077691 74.316 µM -0.481207826521401 0.318701842977203 no 2285 0.315184399459421 3361 757133
SGTC_158 k038-0087 26.446 µM -0.481726491690645 0.318524779196135 no 2286 0.315000127137384 3189 X158
SGTC_338 4055-0136 114 µM -0.481839510500281 0.318486201925399 no 2287 0.314959979712613 3235 2900563
SGTC_1969 st069479 40.1 µM -0.483331430763264 0.317977141955337 no 2288 0.314430213201868 3361 3895485
SGTC_3029 9088683 49.47 µM -0.48349793151537 0.317920351331103 no 2289 0.314371114059338 3361 25236615
SGTC_1462 k081-0014 26.5 µM -0.483981817288825 0.317755330288584 no 2290 0.314199386682685 3240 3270634
SGTC_91 0417-1751 58.384 µM -0.48403048619091 0.317738734587067 no 2291 0.314182116685062 3356 6795624
SGTC_1920 st075728 45.7 µM -0.484048213935864 0.317732689660565 no 2292 0.314175826154959 3404 3400306
SGTC_1391 3442-0225 151 µM -0.484781986203858 0.317482525663261 no 2293 0.313915501070742 3229 5227075
SGTC_2128 5255449 168.493 µM -0.484791829204913 0.317479170468274 no 2294 0.313912009635333 3239 736008
SGTC_3319 9138450 16.7555 µM -0.486437314672237 0.316918482923589 no 2295 0.313328569785719 3231 2029690
SGTC_2349 9023730 187.07 µM -0.486939027115314 0.316747611483304 no 2296 0.313150770393637 3394 4126287
SGTC_1075 aripiprazole 15.2 µM -0.488226445162976 0.316309326135371 no 2297 0.312694727472643 3275 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1504 k297-0033 30 µM -0.488972807203539 0.316055354587984 no 2298 0.312430474349568 3182 4388117
SGTC_2966 9084041 48.03 µM -0.490389464424165 0.315573534221814 no 2299 0.311929165237353 3120 17741380
SGTC_2733 amorolfine 100 µM -0.490440226597889 0.315556275270666 no 2300 0.311911208604376 3323 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_443 clozapine 122 µM -0.490461223485402 0.31554913652426 no 2301 0.31190378128713 3318 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2242 6630449 61.2675 µM -0.492040189817017 0.315012500036618 no 2302 0.31134546621355 3365 691249 YDR170C SEC7
SGTC_1077 5-fluorocytosine 377 nM -0.492154529374854 0.314973655083286 no 2303 0.311305053106695 3329 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_982 1491-0518 27.5 µM -0.492845213975197 0.314739050068163 no 2304 0.311060980275304 3248 3091256
SGTC_1727 st034309 9.9045 µM -0.493845044339963 0.314399569883845 no 2305 0.310707809276185 3439 870305
SGTC_1002 4049-0206 172 µM -0.494217199111813 0.314273249331457 no 2306 0.310576397212734 3276 4662749
SGTC_3125 9127534 49.47 µM -0.49441688026415 0.314205480491067 no 2307 0.310505897498686 3294 1639235
SGTC_3103 9120822 49.47 µM -0.495083968648734 0.313979125946585 no 2308 0.310270424792533 3471 17141819
SGTC_164 4100-3994 89.624 µM -0.49619543729382 0.31360214099475 no 2309 0.309878264920352 3418 4615967
SGTC_2351 9026858 72.31 µM -0.496653019459783 0.313446996024767 no 2310 0.30971687885447 3229 1409300
SGTC_1529 apigenin 74 µM -0.496929260636187 0.313353351378458 no 2311 0.309619468252191 3456 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1567 st069303 68.4 µM -0.49961491568835 0.312443552998106 no 2312 0.308673126609422 3369 5581319
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.499653011732004 0.312430655701477 no 2313 0.308659711859345 3445 16725076
SGTC_227 fluconazole 33.516 µM -0.500304288989746 0.31221020336985 no 2314 0.30843041727421 3315 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_919 tnp00227 403.569 nM -0.50148382020814 0.311811112295203 no 2315 0.308015331010754 3281 1269246 A methoxyflavone. YNL221C POP1
SGTC_2029 5175081 200 µM -0.501965032784668 0.31164835878226 no 2316 0.30784605901237 3312 1380876
SGTC_58 0957-0393 9 µM -0.505753223903625 0.310368420863812 no 2317 0.306514949734805 3396 6997992
SGTC_673 1082-0474 110 µM -0.507405579531537 0.309810847249071 no 2318 0.305935135806296 3310 3098046
SGTC_467 ro 31-8220 72.8 µM -0.508686177757221 0.309379020730975 no 2319 0.305486106246529 3287 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_3064 1327-0027 10 µM -0.51106391643102 0.308577929029233 no 2320 0.304653150772174 3315 16000455 YPR107C YTH1
SGTC_798 1287-0182 476 µM -0.511578286303038 0.308404750625211 no 2321 0.304473092699227 3420 1649755
SGTC_1399 3562-5772 25 µM -0.513602648332696 0.307723601278439 no 2322 0.30376491381003 3323 23847490
SGTC_214 4373-3496 70 µM -0.513936141600383 0.307611452249558 no 2323 0.303648319013519 3440 3779166
SGTC_143 4032-1194 15.74 µM -0.514538022292793 0.307409093864057 no 2324 0.303437942087472 3338 1806963
SGTC_1741 st038134 10.228 µM -0.51659934505673 0.306716500634444 no 2325 0.30271793649655 3497 1272587
SGTC_3351 9150312 21.596 µM -0.516855291912853 0.306630551958067 no 2326 0.302628589490439 3361 4904905
SGTC_1821 st053465 65.6 µM -0.518054077306976 0.306228133345568 no 2327 0.302210269821172 3343 675086
SGTC_1863 st057641 20.1 µM -0.518323427401205 0.306137747716648 no 2328 0.302116315034659 3397 3921635
SGTC_2113 5491891 107.031 µM -0.518490113259506 0.306081818966214 no 2329 0.302058178189599 3344 789979
SGTC_685 1278-0033 54.9 µM -0.519804996159419 0.305640789768017 no 2330 0.301599748370561 3435 3590572
SGTC_222 nsc-310342 10.666 µM -0.520156347348715 0.305522989595978 no 2331 0.301477303881579 3382 432556
SGTC_1374 2889-5571 141 µM -0.521974064566647 0.304913871463094 no 2332 0.300844194244793 3338 2853281
SGTC_584 0986-0246 15.4 µM -0.52258567455634 0.304709041964779 no 2333 0.30063130583473 3450 53315 YDR232W HEM1
SGTC_622 1348-1566 26.3 µM -0.522662616133428 0.304683278398342 no 2334 0.30060452892704 3379 7340407
SGTC_389 tpck 16.7 µM -0.523173743909675 0.304512153989294 no 2335 0.300426675572881 3372 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_393 acivicin 6.25 µM -0.528132643768394 0.302854151030414 no 2336 0.29870363759563 3281 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.528438479759087 0.302752027533247 no 2337 0.298597517903646 3391 5355888
SGTC_27 0485-0001 32.618 µM -0.530343829454986 0.302116148675845 no 2338 0.297936781683267 3373 2054479
SGTC_1742 st038235 28.8875 µM -0.530441138327565 0.302083689552526 no 2339 0.297903054857217 3388 564103 YBR002C RER2
SGTC_1252 0493-0875 34.8 µM -0.530701137436229 0.301996969859361 no 2340 0.297812948853044 3324 3960963
SGTC_2245 6637752 200 µM -0.53081271676693 0.301959757294443 no 2341 0.297774283426391 3374 681890
SGTC_3071 9117417 49.47 µM -0.531233596520433 0.301819409202284 no 2342 0.297628457177516 3296 45595590 YGL055W OLE1
SGTC_654 1124-0271 80.9 µM -0.531508069444612 0.301727898260926 no 2343 0.297533375469846 3339 5403748
SGTC_2751 anetholtrithion 17.25 µM -0.531670668434448 0.301673692653961 no 2344 0.297477055182044 3404 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_858 0438-0351 2.77 µM -0.533152092627615 0.301180032278064 no 2345 0.296964150686687 3363 2799119
SGTC_639 0833-0042 114 µM -0.534243847886933 0.300816455802181 no 2346 0.296586418033294 3335 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1022 4477-0945 21.3 µM -0.534270825793519 0.30080747412349 no 2347 0.296577086827245 3384 4648966
SGTC_253 dyclonine 31.25 µM -0.534921148531176 0.30059100061949 no 2348 0.296352191793064 3426 3180 An oral anasthetic.
SGTC_3229 9132204 49.47 µM -0.535213728734857 0.300493632134098 no 2349 0.296251037023891 3367 17682924
SGTC_3233 9132340 49.47 µM -0.535243929297124 0.300483582425858 no 2350 0.296240596580423 3337 17682950
SGTC_861 0443-0273 110 µM -0.536060163043863 0.300212025430124 no 2351 0.295958485567026 3392 6149169
SGTC_2374 9071832 200 µM -0.537890129442367 0.299603608130574 no 2352 0.295326451625376 3428 17381698
SGTC_2304 7443016 91.4 µM -0.538820094337693 0.299294632713089 no 2353 0.295005498474058 3379 939854
SGTC_2707 st078556 66.6 µM -0.538964632410126 0.29924662376243 no 2354 0.294955629356407 3366 17250899
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.53922184234543 0.299161199003911 no 2355 0.294866895339063 3424 17037758
SGTC_2596 sinensetin 100 µM -0.54001202340127 0.298898832728901 no 2356 0.294594370343961 3329 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2320 7373003 200 µM -0.540304797434858 0.298801648602534 no 2357 0.294493425223726 3406 5415828
SGTC_1388 3346-4487 254 µM -0.540637267513635 0.298691305090009 no 2358 0.294378812724977 3417 3345614
SGTC_2898 9056270 58.44 µM -0.541267330771142 0.298482244198179 no 2359 0.294161667366676 3392 19154699
SGTC_707 0865-0008 204 µM -0.541329153957542 0.298461734272948 no 2360 0.294140364576642 3378 723043
SGTC_1915 st067105 30.6 µM -0.541359965789604 0.298451512645668 no 2361 0.294129747823118 3442 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1873 rapamycin 2 nM -0.542349879953028 0.298123199788193 no 2362 0.293788749931273 3396 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1652 st011932 78 µM -0.542616527893985 0.298034792027765 no 2363 0.293696928413684 3411 1551076
SGTC_103 0844-0104 51.839 µM -0.5431257043822 0.297866006547962 no 2364 0.29352162791679 3471 5375804
SGTC_2441 5730946 39.09 µM -0.544226241793414 0.297501341503922 no 2365 0.293142897918921 3450 1774275
SGTC_328 k915-0120 63.5 µM -0.544446985858497 0.297428222113106 no 2366 0.2930669601447 3428 6624543
SGTC_2398 5228213 48.84 µM -0.544629645183176 0.297367724140033 no 2367 0.293004130734359 3496 80771 YMR134W ERG29
SGTC_3316 9136639 10.545 µM -0.545604420347422 0.29704496726349 no 2368 0.292668942592087 3443 4903665
SGTC_2580 diallyl disulphide 81.36 µM -0.545685412155894 0.297018157353316 no 2369 0.292641100602475 3353 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_796 1234-0020 70.7 µM -0.546453498647233 0.296763960382704 no 2370 0.292377122047097 3412 46495034
SGTC_647 0140-0236 81 µM -0.546652266131613 0.296698194833429 no 2371 0.292308827005918 3404 990837
SGTC_561 1550-0330 72.9 µM -0.547490475312596 0.296420932736984 no 2372 0.29202090616265 3356 6812934
SGTC_1715 st032160 10.2275 µM -0.548347974842766 0.296137412753416 no 2373 0.291726495872887 3408 5289825
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.548916776290687 0.295949415340119 no 2374 0.291531282312714 3382 2374 Ca(2+)-ATPase inhibitor.
SGTC_2440 5628896 157.78 µM -0.548941369998024 0.295941287986835 no 2375 0.291522843087424 3389 5522048
SGTC_2306 7482397 179.52 µM -0.549824181113673 0.295649617923013 no 2376 0.291219985710115 3471 891448
SGTC_3004 9076122 71.4286 µM -0.549976380598954 0.295599346418872 no 2377 0.291167786969407 3442 44782551
SGTC_2845 9003024 42.97 µM -0.550505173973685 0.295424716469893 no 2378 0.290986464551364 3528 2990173
SGTC_2355 9061122 103.12 µM -0.552091770508685 0.294901040178839 no 2379 0.290442739962607 3422 5302957
SGTC_1654 st012436 41.8 µM -0.554658192720781 0.294054866929546 no 2380 0.289564238639385 3430 4323132
SGTC_3101 9120531 49.47 µM -0.55490905974221 0.293972213991056 no 2381 0.289478432373512 3529 24824904
SGTC_1713 st033146 12.748 µM -0.555896096361311 0.293647120222398 no 2382 0.289140943491685 3490 674619
SGTC_1790 st045711 43.5 µM -0.556722555087061 0.293375043018003 no 2383 0.288858502008032 3508 585119
SGTC_1093 fluphenazine 7.97 µM -0.557962129314269 0.29296718382249 no 2384 0.288435122307359 3425 6602611 An atypical antipsychotic.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.558213938278875 0.292884362858183 no 2385 0.28834915207841 3444 91467 include heat shock
SGTC_2153 5569715 200 µM -0.558933961534631 0.292647604345684 no 2386 0.288103395252536 3444 2054701
SGTC_2604 4'-hydroxychalcone 11.32 µM -0.559830087919742 0.292353063733757 no 2387 0.287797669405134 3489 5282362
SGTC_1953 st076800 12.1 µM -0.560289004326038 0.292202279564939 no 2388 0.287641163117572 3380 297591
SGTC_2067 5224629 34.075 µM -0.560396202354752 0.292167063188351 no 2389 0.28760461069703 3479 2835000
SGTC_451 chloral hydrate 100 µM -0.560621060034029 0.292093200031162 no 2390 0.287527945782345 3466 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_849 0386-0493 241 µM -0.560774510429644 0.292042798333992 no 2391 0.287475632629801 3374 726119
SGTC_2511 berberine 10.47 µM -0.561629395307581 0.291762080433537 no 2392 0.287184274136656 3419 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2575 plumbagin 510 nM -0.564919021988142 0.290683042787613 no 2393 0.286064422365602 3392 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1177 0983-0204 23.6 µM -0.565357675328095 0.290539300301017 no 2394 0.285915253315466 3512 766818
SGTC_1938 st074717 56.4 µM -0.566713563025661 0.290095199367206 no 2395 0.285454402260406 3402 17250979
SGTC_2947 9072639 7.68 µM -0.56715122060951 0.289951919057956 no 2396 0.285305722887819 3467 16488146
SGTC_1276 0871-0068 94.2 µM -0.569625029438032 0.289142668240529 no 2397 0.284466024267944 3417 3414906
SGTC_1122 capsaicin 818.572 nM -0.571171147950913 0.288637430309903 no 2398 0.283941816927586 3487 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_3345 9148410 3.559 µM -0.571904551603946 0.288397915432579 no 2399 0.283693320136722 3481 4903596
SGTC_2989 9073649 71.4286 µM -0.573318355186087 0.28793646021358 no 2400 0.283214579778902 3484 21367202
SGTC_2386 9075165 157.42 µM -0.573644626274266 0.287830017230893 no 2401 0.283104153344375 3448 16452277
SGTC_684 1140-0066 328 µM -0.574399769319541 0.287583729976128 no 2402 0.282848654495482 3481 6813534
SGTC_762 1165-0429 115 µM -0.574446364400313 0.28756853641774 no 2403 0.282832892912702 3474 5967793
SGTC_918 glabranin 770.725 nM -0.575785513683188 0.287132033639003 no 2404 0.282380083156551 3458 124049 Also referred to as licorice root.
SGTC_1841 st054148 70 µM -0.576026521287474 0.287053509258326 no 2405 0.282298627719933 3441 675442
SGTC_1415 3966-0071 78.1 µM -0.576048968779928 0.287046196000865 no 2406 0.282291041521216 3478 2893185
SGTC_536 3852-0578 10.6 µM -0.576266174076836 0.286975436385122 no 2407 0.282217641394138 3523 2869208
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.576807614228572 0.286799085795275 no 2408 0.282034712668296 3376 688803
SGTC_3243 9134147 49.47 µM -0.583310902135955 0.284684946651946 no 2409 0.279842012348676 3520 24282180
SGTC_2519 cryptotanshinone 88.04 µM -0.583477483446634 0.284630890974318 no 2410 0.279785955259749 3505 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_280 3448-3607 3.04 µM -0.583581941553382 0.284596996792328 no 2411 0.279750806332363 3502 626179
SGTC_850 0388-0143 75.9 µM -0.583901655696126 0.284493269102471 no 2412 0.27964323959013 3425 67273
SGTC_202 3594-0513 34.79 µM -0.585578128163127 0.283949652123758 no 2413 0.279079524952397 3458 708429
SGTC_1297 1068-0111 14.1 µM -0.588341631275604 0.283054638553285 no 2414 0.278151503633407 3437 767057
SGTC_1531 st059297 52.4 µM -0.592461766566751 0.281722773215199 no 2415 0.276770707938568 3512 7566702
SGTC_3343 9148379 18.9835 µM -0.593381504435759 0.281425873890027 no 2416 0.276462931978636 3542 1955036
SGTC_3304 9125678 46.087 µM -0.594360214652985 0.281110103693341 no 2417 0.27613560626477 3489 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1871 st057448 67.3 µM -0.594474496902078 0.281073242931774 no 2418 0.276097397431446 3611 691747
SGTC_2791 5663188 71.43 µM -0.594556613303449 0.281046758430937 no 2419 0.276069944447589 3499 54690634
SGTC_856 0433-0016 11.3 µM -0.59471055809063 0.280997110809211 no 2420 0.276018481559469 3498 3911780
SGTC_1119 parthenolide 318.541 nM -0.59534754898932 0.280791724534787 no 2421 0.275805589124865 3564 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2647 atorvastatin 60.16 µM -0.595777798984243 0.280653039238238 no 2422 0.275661838441172 3498 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_3161 9100388 49.47 µM -0.596714909178094 0.280351089114922 no 2423 0.275348868402149 3532 25236368
SGTC_954 1189-0853 2.85 µM -0.598415485046329 0.279803541684406 no 2424 0.274781367961614 3513 2828194
SGTC_2239 6685329 187.64 µM -0.598419903808159 0.279802119617848 no 2425 0.274779894124729 3523 805680
SGTC_2850 9015429 58.44 µM -0.601842245790822 0.278701779790995 no 2426 0.273639575626228 3467 6457570
SGTC_3084 9116877 49.47 µM -0.603198653074472 0.278266255995805 no 2427 0.273188271814885 3473 27241325
SGTC_2616 abietic acid 100 µM -0.603255196958676 0.278248107736017 no 2428 0.273169466544816 3544 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2471 5466956 24.79 µM -0.603989982504594 0.278012324305431 no 2429 0.272925151143367 3445 724419
SGTC_1990 st072050 59.8 µM -0.604064986383264 0.277988261989699 no 2430 0.272900218530667 3499 17233948
SGTC_1916 st067606 49.2 µM -0.604146968766892 0.277961962032431 no 2431 0.27287296743193 3493 19590279
SGTC_1475 4092-1048 11.7 µM -0.604626166123657 0.2778082597665 no 2432 0.272713708332815 3524 2881759
SGTC_1424 4048-1941 275 µM -0.605690844001393 0.277466913568504 no 2433 0.272360032559481 3572 X1424
SGTC_1006 4099-6547 255 µM -0.607317335102887 0.276945840668986 no 2434 0.271820168121785 3528 3146833
SGTC_2763 lisinopril 49.32 µM -0.607902193102731 0.276758589072222 no 2435 0.271626172473451 3534 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_3132 9126706 49.47 µM -0.607992920742236 0.276729546732617 no 2436 0.27159608456445 3563 850858
SGTC_1347 1493-0251 600 nM -0.608277046382532 0.276638606454067 no 2437 0.271501871023195 3543 3986378
SGTC_100 0086-0128 49.5915 µM -0.608601680620143 0.276534718493247 no 2438 0.271394245119402 3509 93297
SGTC_2316 5844804 197.44 µM -0.609270378365827 0.276320785200013 no 2439 0.271172618943781 3539 776813
SGTC_721 1187-1332 279 µM -0.609301150418773 0.276310942397782 no 2440 0.271162422349183 3472 25730
SGTC_3063 1327-0034 4 µM -0.60959412860972 0.276217238501396 no 2441 0.271065350984682 3486 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2900 5328528 85.29 µM -0.610314477537273 0.275986913957789 no 2442 0.270826754197682 3546 795359
SGTC_3309 9129340 25.759 µM -0.610573974925622 0.275903965314111 no 2443 0.270740828149045 3515 17158987
SGTC_3289 9119912 71.43 µM -0.611139531386393 0.275723226972169 no 2444 0.270553605488846 3562 17014829
SGTC_897 1000-0139 31.4 µM -0.61233769432468 0.275340515052088 no 2445 0.270157177605212 3549 6151020
SGTC_4 0960-0234 25.671 µM -0.614380125876745 0.274688733807768 no 2446 0.269482082824824 3539 6821112
SGTC_1401 3807-4679 7.6 µM -0.614555216545925 0.274632894260071 no 2447 0.26942424863294 3534 3291456
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.616134779755586 0.274129396514454 no 2448 0.268902784598196 3515 2724 A muscle relaxant with antifungal properties.
SGTC_179 1273-0063 6.77 µM -0.619210889802881 0.273150173755366 no 2449 0.267888719416715 3492 3108139
SGTC_2516 gossypol 71.55 µM -0.62005538679524 0.272881647319849 no 2450 0.267610661337407 3584 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2774 tamoxifen 10.92 µM -0.621284323067781 0.272491113972485 no 2451 0.267206283311228 3585 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_716 1683-5115 658 µM -0.621647271391912 0.272375828778472 no 2452 0.267086915203452 3594 723597
SGTC_1643 st009866 20.2 µM -0.622102974561183 0.272231115688196 no 2453 0.266937079590397 3548 3156273 YOR207C RET1
SGTC_1929 genistein trimethyl ether 50.5 µM -0.623397310018334 0.271820295043921 no 2454 0.266511732620282 3590 136420
SGTC_844 0330-0132 15.3 µM -0.623411298469211 0.271815856810655 no 2455 0.266507137582146 3569 2828079
SGTC_1050 3232-1156 69.3 µM -0.623565328320092 0.271766988851248 no 2456 0.266456543275745 3483 700529
SGTC_663 1486-0733 13.9 µM -0.623744553752825 0.271710132772434 no 2457 0.266397679073307 3526 722445 YPR165W RHO1
SGTC_200 k038-0079 37.545 µM -0.625376017854967 0.27119285223654 no 2458 0.265862149166522 3487 3436683
SGTC_1316 1272-0050 65.9 µM -0.626520113672075 0.270830392356631 no 2459 0.265486924158375 3562 7340392
SGTC_2255 7941087 197.44 µM -0.626816724054462 0.270736462995764 no 2460 0.265389689788867 3599 935561
SGTC_2006 4011487 200 µM -0.626972028888861 0.270687288185434 no 2461 0.265338785201445 3593 45595294
SGTC_120 rhodamine 6G 52.259 µM -0.627148092853722 0.270631545720729 no 2462 0.265281082345326 3561 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_1482 3346-2049 8.48 µM -0.628344238261614 0.270252993765023 no 2463 0.264889228740833 3547 3826804
SGTC_604 1000-0114 314 µM -0.628631550876969 0.270162105515725 no 2464 0.26479514983791 3603 1572745
SGTC_820 1582-0060 59.9 µM -0.628711595939996 0.270136786845971 no 2465 0.264768942557329 3505 3848840
SGTC_1304 1165-0502 251 µM -0.628851919014667 0.270092404791873 no 2466 0.264723003041534 3526 767425
SGTC_513 4245-1575 41.7 µM -0.629273730770157 0.269959014117296 no 2467 0.264584933072181 3550 719745
SGTC_1988 st071872 53.4 µM -0.629458954804625 0.269900450638257 no 2468 0.264524316000837 3581 16414116
SGTC_3074 9116018 49.47 µM -0.630440969657874 0.269590066935767 no 2469 0.264203056439446 3586 17027303
SGTC_1178 0988-0033 191 µM -0.635490474699408 0.267996908219668 no 2470 0.262554288584749 3582 5392207
SGTC_3280 9140961 49.47 µM -0.636119103092926 0.2677989033134 no 2471 0.262349397635034 3534 4901226
SGTC_3165 9101544 49.47 µM -0.636707421820513 0.267613661904615 no 2472 0.262157719153568 3570 5002184
SGTC_2890 9046729 58.44 µM -0.636867041294152 0.267563414343586 no 2473 0.262105726357601 3476 903329
SGTC_804 1595-0054 20.9 µM -0.637377716469177 0.267402687834619 no 2474 0.261939419816216 3547 761523 Stimulates phospholipase C.
SGTC_1748 st037455 53.6035 µM -0.63848209105222 0.267055270941564 no 2475 0.26157995416697 3584 580690
SGTC_2638 epoxomicin 18 µM -0.638782329633919 0.266960860563921 no 2476 0.261482272553708 3549 9915668 A protesome inhibitor.
SGTC_2958 9077254 16.72 µM -0.638785328258439 0.266959917727921 no 2477 0.26148129705577 3614 16457351
SGTC_2456 5770359 74.46 µM -0.638810542605301 0.26695198982822 no 2478 0.261473094521055 3579 3118787
SGTC_726 3448-4391 34.2 µM -0.64062470388696 0.266381893159083 no 2479 0.260883272635069 3664 1356692
SGTC_1009 4106-0057 9.87 µM -0.641193429751511 0.266203299071437 no 2480 0.260698508923067 3610 2928005
SGTC_3076 9116187 49.47 µM -0.643202257633997 0.265572962644446 no 2481 0.26004643429168 3535 27241210
SGTC_3302 9125395 16.351 µM -0.643563188671465 0.265459788833759 no 2482 0.25992936362894 3542 17599668
SGTC_3121 9125696 49.47 µM -0.645360664726553 0.264896535502127 no 2483 0.2593467439808 3625 1235365
SGTC_3111 9122088 49.47 µM -0.645418806220826 0.264878326551954 no 2484 0.259327909729169 3512 16876704
SGTC_244 nsc-207895 1.295 µM -0.645851336992731 0.264742885073233 no 2485 0.259187818673033 3475 42640
SGTC_3211 9128781 49.47 µM -0.64660585194945 0.264506702690518 no 2486 0.258943534826122 3541 17194361
SGTC_2430 5571206 200 µM -0.646849262951464 0.264430531732112 no 2487 0.258864752823356 3634 1731771
SGTC_144 4161-2749 112.381 µM -0.646874695567315 0.264422573710919 no 2488 0.258856522060558 3531 797501 YMR168C CEP3
SGTC_348 k064-0012 10.7 µM -0.647409941014281 0.264255120416563 no 2489 0.258683331881631 3529 5066323
SGTC_3062 9077494 49.47 µM -0.647850143674828 0.264117442050041 no 2490 0.258540939807355 3563 16459633
SGTC_1830 st055982 50.3 µM -0.648022053192397 0.264063685325477 no 2491 0.25848534336849 3570 455313 An antimicrobial agent.
SGTC_3219 9131112 49.47 µM -0.648025739621903 0.264062532626767 no 2492 0.258484151225693 3538 17612988 YMR079W SEC14
SGTC_1465 k213-0056 144 µM -0.648675292467809 0.263859465906335 no 2493 0.258274138850692 3523 24048857 YMR208W ERG12
SGTC_2003 4023581 200 µM -0.650618824401896 0.263252344311391 no 2494 0.257646287831996 3608 16641307
SGTC_1406 3909-7906 11.9 µM -0.651894696764827 0.262854174882124 no 2495 0.257234553146989 3613 X1406
SGTC_601 0986-0029 62.9 µM -0.653098686965764 0.2624787207894 no 2496 0.256846329356585 3606 24747981
SGTC_2908 7930301 100 µM -0.653204952810925 0.262445595880345 no 2497 0.256812078836682 3551 2223178
SGTC_3110 9122132 49.47 µM -0.653585284112159 0.262327057550571 no 2498 0.256689513825693 3676 918317
SGTC_274 sirtinol 40.1 µM -0.655122658242415 0.261848181842436 no 2499 0.256194392427927 3595 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2065 5221596 34.26 µM -0.659292639029097 0.260551538272466 no 2500 0.254853934173009 3603 788581
SGTC_1505 k297-0037 20.6 µM -0.660452256671768 0.260191546855998 no 2501 0.254481823535459 3585 4089396
SGTC_2276 7947513 42.08 µM -0.660619461084945 0.260139661113186 no 2502 0.254428192669992 3504 2105100
SGTC_1481 3346-2004 36 µM -0.661335677706068 0.25991746998253 no 2503 0.254198533016442 3619 2770522
SGTC_2404 5161160 200 µM -0.662049000664239 0.259696273886905 no 2504 0.253969909331736 3597 2831543
SGTC_186 3455-3465 67.277 µM -0.665131970127129 0.25874138683752 no 2505 0.252983043986452 3570 755278
SGTC_2513 baicalein 25.65 µM -0.666539863838931 0.25830592563097 no 2506 0.252533046169408 3582 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2472 5377652 49.4 µM -0.667948617069634 0.257870579038347 no 2507 0.25208319610305 3615 1610903
SGTC_760 0568-0725 82.9 µM -0.669398342712612 0.257422968578329 no 2508 0.2516207042634 3623 3916171
SGTC_571 k831-0106 44.2 µM -0.669619653111159 0.257354673355682 no 2509 0.251550141219429 3604 4783639
SGTC_387 norethindrone acetate 66.7 µM -0.671763678981845 0.256693526068229 no 2510 0.250867077400299 3619 541197
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.67205176424066 0.256604757463243 no 2511 0.250775371387669 3612 15053
SGTC_978 1416-0512 87.4 µM -0.672783723564312 0.256379288498156 no 2512 0.250542447069275 3653 6814003
SGTC_2832 7992762 51.95 µM -0.673128895907488 0.256272999228312 no 2513 0.250432646006918 3535 2985177
SGTC_767 0929-0023 86 µM -0.673263981376037 0.256231408477796 no 2514 0.250389681583007 3693 1204563
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.675929238124013 0.255411536891548 no 2515 0.249542786612476 3644 16623 A steroid.
SGTC_45 0kpi-0036 14.9 µM -0.676281452033364 0.255303293436721 no 2516 0.249430983328583 3626 2795021
SGTC_3019 9081971 49.47 µM -0.676385286781064 0.255271387202202 no 2517 0.249398028139759 3680 16451803
SGTC_288 1315-0019 35.1 µM -0.678269684840632 0.254692713701361 no 2518 0.248800358091871 3676 6811474
SGTC_2359 9039622 200 µM -0.678965904709578 0.254479087783148 no 2519 0.248579732763884 3616 6463596
SGTC_286 k060-0067 22.9 µM -0.679171047909912 0.254416160200079 no 2520 0.248514744757118 3617 5985051
SGTC_778 3456-2434 196 µM -0.679511711402094 0.254311679847307 no 2521 0.248406844821807 3683 5539063
SGTC_1702 st027038 51 µM -0.679632196733777 0.25427473278449 no 2522 0.24836868891935 3649 5521182
SGTC_664 1222-0054 14.9 µM -0.679640440439775 0.254272204938775 no 2523 0.248366078375154 3637 6813991
SGTC_329 k048-0121 21.3 µM -0.679721853220997 0.254247241273506 no 2524 0.248340298078254 3641 6832902
SGTC_2337 9009472 200 µM -0.680108489059863 0.254128704366353 no 2525 0.248217884853618 3668 5742383
SGTC_2224 6650123 117.647 µM -0.680121429310085 0.2541247375758 no 2526 0.248213788382444 3613 2908370
SGTC_452 diindolylmethane 8 µM -0.680409666277584 0.254036387913716 no 2527 0.248122551082616 3610 3071 Inhibits expression of several cancer promoting factors.
SGTC_701 4424-0219 185 µM -0.682729002327288 0.253326057878087 no 2528 0.247389049902638 3682 2911779
SGTC_2017 5132927 60.65 µM -0.682745951974849 0.253320870650527 no 2529 0.247383693764193 3634 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_948 3448-0295 75.3 µM -0.682762489347687 0.253315809648306 no 2530 0.247378467965511 3672 678569
SGTC_2723 salbutamol 83.58 µM -0.685256407040845 0.252553194310811 no 2531 0.246591067483994 3621 9884233 β2-adrenoceptor agonist
SGTC_1968 st069590 43.6 µM -0.685872467219128 0.252364995682941 no 2532 0.246396766812864 3605 6384066
SGTC_2819 7996655 46.38 µM -0.685960576504021 0.252338085449533 no 2533 0.24636898452621 3551 6456960
SGTC_1644 st010134 20.9 µM -0.686383548474337 0.252208922915459 no 2534 0.246235637983214 3637 3818134
SGTC_160 3453-0671 289.699 µM -0.688584174152444 0.251537483000562 no 2535 0.245542491516421 3638 5322268
SGTC_1213 1315-0166 115 µM -0.690719260820004 0.250886943698725 no 2536 0.244870991433116 3638 768401
SGTC_2700 st077718 96.8 µM -0.691610042649997 0.250615795007384 no 2537 0.24459112661353 3653 904970
SGTC_1123 mangostin 811.285 nM -0.69223183178692 0.250426618128611 no 2538 0.244395875753433 3638 5281650 An antioxidant.
SGTC_201 4262-0159 12.803 µM -0.693601150014342 0.250010275497328 no 2539 0.243966186171616 3644 1341029
SGTC_675 1309-0189 238 µM -0.693670881859462 0.249989083289798 no 2540 0.243944315356452 3660 4246530
SGTC_171 k064-0041 9.68 µM -0.694074571795077 0.24986641660237 no 2541 0.243817722145798 3632 53325
SGTC_529 4076-0302 30.3 µM -0.694640964058232 0.249694364473084 no 2542 0.243640166867487 3643 5816522
SGTC_466 geldanamycin 89.2 µM -0.695089963428737 0.249558017328541 no 2543 0.243499462086739 3562 5288382 HSP90 inhibitor.
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.696204251794836 0.249219813573855 no 2544 0.243150462675787 3604 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2141 5621638 7.665 µM -0.696648401329921 0.249085075289859 no 2545 0.243011428754019 3677 2856238
SGTC_2173 5763948 167 µM -0.69676295635292 0.249050329886788 no 2546 0.242975576109776 3680 2867177
SGTC_2693 st077581 40.7 µM -0.698503708923726 0.248522663954819 no 2547 0.242431119593515 3707 25238761
SGTC_29 0299-0004 12.984 µM -0.702181872660374 0.247409681872802 no 2548 0.241282874455096 3575 16871 A napthoquinone isolated from Swertia calycina.
SGTC_1131 3454-3128 32.3 µM -0.70253048366643 0.247304333430841 no 2549 0.241174198988705 3737 710982
SGTC_806 3966-4455 5.86 µM -0.702745451236683 0.247239383298939 no 2550 0.241107198588681 3645 714982
SGTC_1427 4048-4900 550 nM -0.702999478937318 0.247162643329171 no 2551 0.241028037099485 3688 24132586
SGTC_3288 9119690 36.221 µM -0.703572691538408 0.246989526675771 no 2552 0.240849461420995 3673 17595618 YKL019W RAM2
SGTC_2346 9031566 143.75 µM -0.704217743072553 0.246794791468868 no 2553 0.240648591521745 3667 4771086
SGTC_1729 st035615 45.989 µM -0.705868731036626 0.24629674782945 no 2554 0.240134887338691 3714 17385451
SGTC_1688 st021091 57.6 µM -0.706434349439088 0.24612624511767 no 2555 0.239959032985904 3704 3656366
SGTC_423 5-fluorouracil 457 µM -0.707826622770043 0.245706821438486 no 2556 0.239526465719175 3659 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_678 1218-2179 85.9 µM -0.70882624438261 0.245405921324165 no 2557 0.239216154695173 3678 6820081 YOR116C RPO31
SGTC_1945 st075991 56.6 µM -0.708951910308835 0.245368108136307 no 2558 0.239177159961182 3612 1084980
SGTC_1105 epirubicin 18.1 µM -0.709610076122208 0.245170115575014 no 2559 0.238972984732404 3684 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_187 1488-2104 32.728 µM -0.710353688836554 0.244946521878954 no 2560 0.238742416999185 3733 2852859
SGTC_2847 9005661 71.43 µM -0.710570484079531 0.24488135531682 no 2561 0.238675219461517 3616 2991449
SGTC_1418 3966-3099 2.4 µM -0.711154922551688 0.244705725230174 no 2562 0.238494119332395 3693 740335
SGTC_3321 9137793 26.8275 µM -0.711554150774307 0.244585791827003 no 2563 0.238370453619066 3678 4904192
SGTC_190 3970-0790 3.722 µM -0.713100733684179 0.244121477035709 no 2564 0.237891712769463 3658 2832352
SGTC_2105 5350118 200 µM -0.714875860353315 0.243589135327043 no 2565 0.237342877236731 3717 2133313
SGTC_2742 clothiapine 36.27 µM -0.715167416197788 0.243501760793259 no 2566 0.237252800218982 3646 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1758 st042942 75.2445 µM -0.715350077065147 0.243447028936008 no 2567 0.237196376186333 3649 669317
SGTC_626 0214-0009 33 µM -0.715530401432318 0.243393003699465 no 2568 0.237140681131146 3726 3437874
SGTC_930 2810-3379 265 µM -0.71605209394135 0.243236740950199 no 2569 0.236979591446515 3727 1015764
SGTC_1565 sinapyl alcohol 95.1 µM -0.71927752193237 0.242271832589238 no 2570 0.235984971402297 3705 5280507 A phenol propionate derived from cinnamic acid.
SGTC_281 1672-3440 14.9 µM -0.720753324679942 0.241831029067325 no 2571 0.235530648731344 3728 6833000
SGTC_815 1582-0027 36.9 µM -0.721068749453853 0.241736872175655 no 2572 0.235433608531681 3739 3128206
SGTC_659 k018-0002 107 µM -0.721356697275006 0.24165093475655 no 2573 0.235345040864911 3680 6797879 YHR007C ERG11
SGTC_2572 astragaloside iv 100 µM -0.722028197125523 0.241450591497569 no 2574 0.235138570837331 3720 45006101 An anti-inflammatory agent.
SGTC_520 3584-0023 682 µM -0.723119253875766 0.241125265113397 no 2575 0.23480331060275 3726 1340790
SGTC_2568 diosmetin 100 µM -0.723198963966914 0.241101506862084 no 2576 0.234778827624515 3692 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_800 3448-7362 155 µM -0.724165542524469 0.240813511450116 no 2577 0.234482055074003 3785 15991913
SGTC_2207 7258803 200 µM -0.725041582781677 0.240552654019169 no 2578 0.234213260254521 3661 3666799
SGTC_969 1313-0238 134 µM -0.72561159565407 0.240383004643641 no 2579 0.234038455253358 3734 5212874
SGTC_2676 harmalol 100 µM -0.728206614047798 0.239611489888411 no 2580 0.233243558850869 3711 5459187 A monoamine oxidase inhibitor
SGTC_933 2914-0560 114 µM -0.728213661219035 0.239609396563383 no 2581 0.233241402229626 3736 463887
SGTC_2844 9010103 25.97 µM -0.728684340415102 0.239469606392925 no 2582 0.233097386973593 3716 2480525
SGTC_39 0986-0283 58.349 µM -0.730049206522879 0.239064497572756 no 2583 0.23268005370886 3760 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1417 3966-0327 90.4 µM -0.730121720055601 0.239042985161706 no 2584 0.232657892968357 3790 651118
SGTC_84 0443-0269 128.823 µM -0.730647880910107 0.238886922019746 no 2585 0.232497128967557 3650 6150058
SGTC_3054 9094397 49.47 µM -0.731095135511398 0.238754306873324 no 2586 0.232360522691282 3727 2598354
SGTC_587 k089-0003 57 µM -0.731624756681517 0.238597321372691 no 2587 0.232198816710372 3654 9659696
SGTC_2729 fluphenazine 10.66 µM -0.732690449270198 0.238281609724662 no 2588 0.231873625206385 3676 3372 An atypical antipsychotic.
SGTC_2232 chlorophetanol 41.5365 µM -0.733833881098619 0.237943122444376 no 2589 0.231524994178849 3793 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1329 1447-1697 50.6 µM -0.734368711264352 0.237784888537063 no 2590 0.231362025446872 3736 2840515
SGTC_3197 9113331 49.47 µM -0.734914632450244 0.23762343280109 no 2591 0.231195743157043 3731 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1183 1254-0324 198 µM -0.735016880905115 0.237593199595613 no 2592 0.231164606686501 3772 5799357
SGTC_1375 2910-0797 186 µM -0.738488091114856 0.236568072416614 no 2593 0.230108950637341 3759 742508
SGTC_2665 lovastatin 100 µM -0.738675669531774 0.236512745648247 no 2594 0.230051981660672 3756 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1485 3909-9022 254 µM -0.738814609200221 0.236471769603107 no 2595 0.230009789726267 3759 714516
SGTC_1343 1487-0095 224 µM -0.739097105930936 0.236388467802158 no 2596 0.229924017044335 3704 4560101 YGL055W OLE1
SGTC_2275 7947463 200 µM -0.74135367759307 0.235723636856905 no 2597 0.229239511645182 3688 1225414
SGTC_1521 st012942 49.4 µM -0.741405248085631 0.235708455223992 no 2598 0.229223881688514 3789 24207259
SGTC_2253 7938677 135.83 µM -0.744189315510558 0.234889665448873 no 2599 0.228380975506674 3777 2301972
SGTC_2356 9061756 188.97 µM -0.74476815062271 0.234719628563826 no 2600 0.228205945955206 3744 20104043
SGTC_2281 7943571 200 µM -0.747655222475898 0.233872547977217 no 2601 0.227334073243713 3845 1244024
SGTC_1855 st056195 39.6 µM -0.748109166663997 0.233739512879405 no 2602 0.227197156664253 3684 4028379
SGTC_2156 5649887 115 µM -0.74829145392768 0.23368610269139 no 2603 0.227142189091301 3800 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_249 wiskostatin 11.211 µM -0.749689093261088 0.233276819103402 no 2604 0.226720988949021 3746 2775510 A n-wasp and actin depolymerizer.
SGTC_1028 k015-0029 4.8 µM -0.749854785081009 0.233228324433195 no 2605 0.22667108440594 3740 4588309
SGTC_129 0088-0017 176.636 µM -0.751220177294919 0.232828914648583 no 2606 0.226260079488055 3638 182446
SGTC_150 3970-0969 77.2 µM -0.754685593915377 0.231816905971301 no 2607 0.2252188261833 3856 6615640
SGTC_752 1896-0090 130 µM -0.75480246497236 0.231782818779395 no 2608 0.225183757327356 3753 772567
SGTC_357 1325-0123 420 µM -0.754856322971158 0.231767111228406 no 2609 0.22516759749481 3759 1098503
SGTC_3347 9188721 44.724 µM -0.755692048158544 0.231523450075661 no 2610 0.224916926389513 3794 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_3123 9126162 49.47 µM -0.756727771710078 0.231221676346909 no 2611 0.224606486503509 3843 25239884
SGTC_1851 st056236 18.9 µM -0.757148975600532 0.231099015016659 no 2612 0.224480307617578 3749 5393171
SGTC_1935 st074532 41.6 µM -0.757301825344347 0.231054511700893 no 2613 0.224434528790878 3792 2829742
SGTC_1967 st070177 51.4 µM -0.759917962902332 0.230293546201356 no 2614 0.223651811826677 3814 5729214
SGTC_2909 7941780 10.49 µM -0.760275978481547 0.230189518033199 no 2615 0.223544818735394 3744 1243215
SGTC_1618 st003135 44.5 µM -0.760978080639899 0.229985585371323 no 2616 0.223335079790627 3695 1270615
SGTC_645 0845-0943 5.41 µM -0.762181761666813 0.229636199448791 no 2617 0.222975764907349 3788 1885106
SGTC_689 0833-0039 98 µM -0.763139195421271 0.229358502813379 no 2618 0.222690193394442 3760 5374726
SGTC_1027 k015-0025 8.67 µM -0.763409400255871 0.229280165956609 no 2619 0.222609637768064 3761 3598955
SGTC_2490 carminic acid 95.39 µM -0.763417984905832 0.229277677370298 no 2620 0.222607078715868 3694 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2330 7979373 200 µM -0.763683630447211 0.229200677422536 no 2621 0.22252789905833 3743 1863007
SGTC_630 4356-0227 183 µM -0.76399322370886 0.229110957101368 no 2622 0.222435640387562 3760 779312
SGTC_2497 7-hydroxyflavone 100 µM -0.767822706311733 0.228002800903672 no 2623 0.221296261347616 3750 5281894
SGTC_230 MPP+ 141.667 µM -0.768676671144081 0.227756096654619 no 2624 0.2210426386614 3776 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1877 wortmannin 25 µM -0.769275941469315 0.227583061550023 no 2625 0.220864758162315 3787 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1922 5578187 25 µM -0.770820452406378 0.227137436261367 no 2626 0.220406681338716 3776 1350412
SGTC_2816 7982706 58.44 µM -0.771305906496127 0.226997473769582 no 2627 0.220262816107086 3824 2981853
SGTC_2670 beta-carotene 100 µM -0.771737156570491 0.226873179776358 no 2628 0.220135059510091 3706 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2569 tetrandrine 100 µM -0.772342668063397 0.226698725333419 no 2629 0.219955750220214 3814 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1809 st050081 57.6 µM -0.772718194588364 0.226590570104047 no 2630 0.219844588182226 3840 5036894
SGTC_1829 berberine 14.4 µM -0.773132038002188 0.226471412988128 no 2631 0.219722121070158 3813 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1749 st037932 54.2 µM -0.774088149463066 0.226196257047496 no 2632 0.219439332459403 3823 594497
SGTC_1448 4255-0083 152 µM -0.776317245708905 0.225555487441323 no 2633 0.218780846443683 3858 5399660
SGTC_1001 4048-4355 44.4 µM -0.777145828505217 0.225317567562708 no 2634 0.218536369187669 3793 21824233
SGTC_2013 4024628 200 µM -0.777244291723188 0.225289304211734 no 2635 0.218507327612126 3816 5230760
SGTC_2914 7968218 45.32 µM -0.781027362669674 0.224204915098131 no 2636 0.21739320075165 3792 2977111
SGTC_506 n9-isopropylolomoucine 153 µM -0.7860159139107 0.222779525483228 no 2637 0.215929082005851 3783 6610355
SGTC_246 cycloheximide 667 µM -0.786530991241188 0.222632646013341 no 2638 0.215778235087454 3688 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2602 kawain 100 µM -0.787020372886007 0.222493145081555 no 2639 0.215634970079041 3764 5369129
SGTC_1081 sertraline 6 µM -0.787760024112387 0.222282398059085 no 2640 0.215418544107707 3822 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_3022 9087993 49.47 µM -0.789317451363758 0.221839016700828 no 2641 0.214963244673756 3834 17173644
SGTC_2129 girgensonine 121.053 µM -0.789877687997017 0.221679647493327 no 2642 0.214799601456291 3864 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2941 9056145 11.23 µM -0.791753018087455 0.221146652978736 no 2643 0.214252350807615 3691 2119517
SGTC_1186 1319-0216 26 µM -0.791973805971028 0.22108395031465 no 2644 0.214187974860447 3888 4565136
SGTC_2318 6029776 164 µM -0.792701627729236 0.220877324602753 no 2645 0.213975840868947 3799 818325
SGTC_776 4476-4378 112 µM -0.797002669534252 0.219658535318042 no 2646 0.212724740464666 3897 2892008
SGTC_2608 thymoquinone 42.66 µM -0.79858763030353 0.219210379462335 no 2647 0.212264781254091 3796 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_193 1273-0060 1.558 µM -0.799455405158851 0.218965234466868 no 2648 0.212013197472844 3683 2847393 YHR072W ERG7
SGTC_1395 3486-0190 4.35 µM -0.7997594786736 0.218879371512301 no 2649 0.211925082283193 3808 6748079
SGTC_770 0389-1121 67.2 µM -0.800801739103453 0.218585209582013 no 2650 0.211623216030378 3967 6753108
SGTC_430 0958-0115 16.4 µM -0.801223178121558 0.218466329572456 no 2651 0.211501227616329 3807 6833180
SGTC_2391 6285546 200 µM -0.804531188600748 0.217534496163559 no 2652 0.210545132269797 3827 846083
SGTC_953 1188-0045 9.7 µM -0.80461332905743 0.217511387246593 no 2653 0.210521424001155 3874 6144426
SGTC_834 0312-0008 75.7 µM -0.805014291628589 0.21739860311841 no 2654 0.210405716332331 3819 6385573 YIL048W NEO1
SGTC_2799 7812892 81.82 µM -0.805401580286584 0.217289697300148 no 2655 0.210293990063016 3847 20205235
SGTC_2044 5102272 200 µM -0.80763874269838 0.216661222781027 no 2656 0.20964928846577 3856 592666
SGTC_1300 1094-0077 113 µM -0.807729929755704 0.216635628390957 no 2657 0.209623035014828 3786 5532636
SGTC_1228 0124-0032 52.5 µM -0.807823026517206 0.216609499789281 no 2658 0.209596233740233 3921 X1228
SGTC_947 3447-0010 211 µM -0.811736388527104 0.215512822865651 no 2659 0.208471454806066 3830 748350
SGTC_3018 9082602 49.47 µM -0.813628698994899 0.214983680742818 no 2660 0.207928845913527 3842 17332089
SGTC_6 0844-0013 19.835 µM -0.815043044388439 0.214588683980015 no 2661 0.207523835788692 3957 1584900
SGTC_52 0329-0193 875 nM -0.815125629370322 0.214565632783608 no 2662 0.207500201275309 3942 3739292
SGTC_1597 7-benzyloxygramine 47.5 µM -0.817486381619255 0.213907306349156 no 2663 0.206825264352516 3835 260807
SGTC_1308 1187-1617 41.4 µM -0.818993554042906 0.213487627510106 no 2664 0.206395045636925 3850 2882570
SGTC_1757 st041620 31.8375 µM -0.819105419128398 0.213456497323451 no 2665 0.206363135172728 3937 5289815
SGTC_825 1988-2224 89.6 µM -0.819724088059929 0.21328437986688 no 2666 0.206186707416769 3846 1180859
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.82031493034519 0.213120079521946 no 2667 0.206018298578321 3870 689007
SGTC_3203 9113543 49.47 µM -0.822427491378478 0.212533226626574 no 2668 0.205416819156382 3955 17018012
SGTC_3036 9090181 49.47 µM -0.822701677610225 0.212457129106401 no 2669 0.205338830547865 3882 25236586
SGTC_364 0083-0097 67.7 µM -0.824042278732506 0.212085288543763 no 2670 0.204957767772408 3964 5207356
SGTC_1311 1190-0148 100 µM -0.824727501650795 0.211895376325189 no 2671 0.204763157209104 3918 1961333
SGTC_1971 st069429 63.5 µM -0.826015306920704 0.211538725345359 no 2672 0.204397704393808 3872 1246522 YGL099W LSG1
SGTC_640 3381-0960 37.1 µM -0.82966277193508 0.210530488284276 no 2673 0.203364737682404 3906 1745025
SGTC_967 1306-0166 352 µM -0.82974192486655 0.210508640037749 no 2674 0.203342356057716 3817 4437607
SGTC_131 0141-0277 33.849 µM -0.833544351289816 0.209460640789158 no 2675 0.202268897726394 3839 1547771
SGTC_1350 1495-0454 146 µM -0.834529055871629 0.209189744353502 no 2676 0.201991460548307 3898 1069057
SGTC_2058 5236698 133 µM -0.835694093808909 0.2088695039664 no 2677 0.201663509383956 3893 766665
SGTC_2851 9015922 71.43 µM -0.836995263503995 0.208512185941134 no 2678 0.201297615213733 3885 2996893
SGTC_2755 lomerizine 42.69 µM -0.837064405652278 0.208493208703835 no 2679 0.201278183304898 3881 3949 A calcium channel blocker.
SGTC_118 0083-0097 135.343 µM -0.838277488942312 0.208160423102291 no 2680 0.200937437856933 3930 5207356
SGTC_1262 0737-0114 49.6 µM -0.83875500966398 0.208029510690434 no 2681 0.200803401073041 3932 765919
SGTC_2532 xanthone 78.9 µM -0.839134561412295 0.207925491169894 no 2682 0.200696901791912 3870 7020 An insecticide.
SGTC_665 3914-0008 307 µM -0.839851012709219 0.207729225061057 no 2683 0.200495963538866 3846 1069549
SGTC_3220 9131269 49.47 µM -0.840006629126224 0.20768660965802 no 2684 0.200452334831116 3917 17722206
SGTC_1568 digitonin 820 nM -0.840562458474786 0.207534438512206 no 2685 0.200296548760198 3864 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2502 avocadyne acetate 18.59 µM -0.840663795821104 0.207506702172214 no 2686 0.200268154095475 3844 3952079
SGTC_2546 rhodinyl acetate 100 µM -0.840808070065132 0.207467217652835 no 2687 0.200227732710626 3802 6708682
SGTC_901 1112-0062 60.1 µM -0.84284515793298 0.206910188054171 no 2688 0.199657524290345 3883 1908457
SGTC_1875 nocodazole 6 µM -0.843454333062678 0.206743784808293 no 2689 0.199487197904804 3864 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_404 fumagillin 50 µM -0.845587982494578 0.206161578838844 no 2690 0.19889131596472 3880 12015870 A methionine aminopeptidase binder.
SGTC_1913 st060213 96.1 µM -0.84582262972623 0.206097610353869 no 2691 0.198825849633838 3939 688959
SGTC_57 miconazole 162.5 nM -0.846082436040271 0.206026796843092 no 2692 0.198753379101447 3850 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_353 1988-1175 58.3 µM -0.846393033157587 0.205942158593024 no 2693 0.198666761855245 3749 2788357
SGTC_1569 carminic acid 40.6 µM -0.848815548181541 0.205282727134344 no 2694 0.197991968551875 3970 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2186 6124449 200 µM -0.850069060277596 0.204942002337806 no 2695 0.197643345972758 3898 3834182 YLR033W RSC58
SGTC_2701 st077767 14.721 µM -0.851336652740814 0.204597792410684 no 2696 0.197291184973477 3891 5721188
SGTC_37 0566-0070 1.56 µM -0.853336783619141 0.204055364586286 no 2697 0.196736283608501 3911 1626686
SGTC_2093 5331342 194.4 µM -0.853836769075376 0.203919904413719 no 2698 0.196597719197062 3988 33839
SGTC_2636 apigenin dimethyl ether 100 µM -0.854250325976586 0.203807900679921 no 2699 0.196483152015661 3928 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2716 st080858 38.6235 µM -0.854562940325914 0.203723259587579 no 2700 0.196396575686888 3893 5296050
SGTC_1787 fluconazole 80 µM -0.856548907929908 0.203186043679687 no 2701 0.195847116232154 3747 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1454 4239-0054 42.6 µM -0.857245411640549 0.202997835803901 no 2702 0.195654635085214 4042 1340767
SGTC_1384 3089-0840 101 µM -0.857374482492069 0.202962969967153 no 2703 0.195618978537944 3878 1069836
SGTC_352 k048-0007 5.11 µM -0.857387412305253 0.202959477441058 no 2704 0.195615406821894 3922 6811911
SGTC_980 1473-0395 201 µM -0.858150904909634 0.202753310890158 no 2705 0.195404570747317 3811 768876
SGTC_145 3737-0113 38.366 µM -0.858329214450541 0.202705179845355 no 2706 0.195355351020226 3896 6849351
SGTC_1845 st056753 3.01 µM -0.858371277111691 0.202693826878289 no 2707 0.195343741339062 3872 5375839
SGTC_884 0851-0618 334 µM -0.860483399693133 0.202124240906264 no 2708 0.194761315171284 3941 9642473
SGTC_1540 guanosine 70.6 µM -0.861219264438706 0.201926021999988 no 2709 0.194558645932369 3808 6802 Guanosine is a purine nucleoside
SGTC_3209 9113616 49.47 µM -0.863559777926955 0.201296335116446 no 2710 0.193914883870377 3911 16649353
SGTC_2240 6690706 185.951 µM -0.867457787989093 0.200250239128975 no 2711 0.192845615376918 3790 805876
SGTC_705 1124-0212 310 µM -0.870158081301688 0.199527489431217 no 2712 0.192107010238737 3866 9554485
SGTC_3000 9075062 71.4286 µM -0.872859679816145 0.198805963833068 no 2713 0.191369782797712 3895 17057871
SGTC_1912 st060209 90.8 µM -0.873159036309367 0.198726110538926 no 2714 0.191288199549899 3978 688787
SGTC_2468 5987765 72.9 µM -0.875408339388334 0.19812672813238 no 2715 0.1906758819278 3980 26772094
SGTC_1810 st050138 53 µM -0.877413245604891 0.197593392440007 no 2716 0.190131110638887 3894 3444541
SGTC_1090 efavirenz 20.7 µM -0.877449730977854 0.197583694820497 no 2717 0.190121205735778 3987 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2368 9071271 200 µM -0.880273804169176 0.196833944347093 no 2718 0.189355500026947 3954 27209959
SGTC_5 0352-0601 109.883 µM -0.880411350804493 0.196797471759264 no 2719 0.189318254831124 3865 762456
SGTC_2343 7990716 14.84 µM -0.880486799681493 0.196777467077252 no 2720 0.189297826525274 3936 6456862
SGTC_2534 helenine 20.12 µM -0.881055238045627 0.196626789666 no 2721 0.189143961530773 3934 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_374 0880-0231 82.3 µM -0.8828307087935 0.196156611376789 no 2722 0.188663872959555 3873 6833587
SGTC_643 k048-0106 28.4 µM -0.883359004815513 0.196016840308437 no 2723 0.188521166473543 3966 6763920
SGTC_2892 9047358 58.44 µM -0.885036955457728 0.195573306407336 no 2724 0.188068350012962 3943 6466771
SGTC_2795 7780010 54.55 µM -0.885364568650753 0.195486779336327 no 2725 0.187980017796433 3959 953673
SGTC_1407 3909-7909 12.3 µM -0.885902031464857 0.195344878512377 no 2726 0.18783516067783 3924 4411780
SGTC_860 0443-0016 25.1 µM -0.886212854825077 0.195262843557681 no 2727 0.187751418953914 3981 5337942
SGTC_3205 9113483 49.47 µM -0.886343306422672 0.195228419979648 no 2728 0.187716279683972 4025 17018033
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.889284081189018 0.194453387036657 no 2729 0.186925212290399 3996 94937 An inhibitor of serotonin biosynthesis.
SGTC_2121 5257820 149.641 µM -0.893934717323678 0.193231554380643 no 2730 0.185678410587162 4017 791256
SGTC_511 blebbistatin 171 µM -0.89504770521099 0.192939842383086 no 2731 0.185380793516842 4031 3476986 A myosin inhibitor.
SGTC_1361 1608-0041 5.61 µM -0.895591393883105 0.192797440457439 no 2732 0.185235516888647 3923 X1361
SGTC_1181 1222-0449 220 µM -0.895738038057389 0.192759042685878 no 2733 0.185196344861682 3996 658318
SGTC_1453 4237-0541 195 µM -0.896280425202668 0.192617062935731 no 2734 0.18505150550701 3938 739892
SGTC_2216 7189485 200 µM -0.900746530107052 0.19145040979754 no 2735 0.183861551431218 3972 731273
SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.900761407715796 0.19144653066113 no 2736 0.183857595405462 3981 229346 A bile salt which induces apoptosis.
SGTC_1012 4112-3522 18 µM -0.903404037300915 0.190758264733726 no 2737 0.183155749024982 3995 3112398
SGTC_3261 9137475 49.47 µM -0.903799877796409 0.190655300031225 no 2738 0.183050763282221 3876 17027690
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.905323578783006 0.190259278515252 no 2739 0.182646994253638 4001 5282309
SGTC_2483 5729050 27.16 µM -0.905838658264357 0.190125519797078 no 2740 0.182510628027584 3951 2865180
SGTC_1919 st067113 52.3 µM -0.906445207817106 0.189968081730255 no 2741 0.182350126848238 4024 1268243
SGTC_168 3970-0862 530.542 µM -0.906874663798884 0.189856659146844 no 2742 0.182236540355772 3960 3135186
SGTC_1190 1486-1332 13 µM -0.90734871191138 0.18973371378033 no 2743 0.182111211080291 3983 4150046
SGTC_1484 3473-2379 286 µM -0.90860705646426 0.189407597070676 no 2744 0.181778790217443 4090 671917
SGTC_3250 9135583 49.47 µM -0.911101661182962 0.188762107766038 no 2745 0.181120905633713 4008 7699353
SGTC_585 0kpi-0023 191 µM -0.911540504908186 0.188648695525212 no 2746 0.181005326922763 3905 64601
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.911814518142452 0.188577902433314 no 2747 0.180933183225223 4014 65057 A dermal irritant. YDR527W RBA50
SGTC_3013 9080133 71.4286 µM -0.912388618236175 0.188429633078569 no 2748 0.180782089462459 4083 17050193
SGTC_1703 st026983 48.3 µM -0.912412686623781 0.188423418652599 no 2749 0.180775756784194 3991 1104023
SGTC_1870 st057514 26.5 µM -0.913158220211155 0.188230985468635 no 2750 0.180579666927318 3968 5393161
SGTC_1322 1348-1070 12 µM -0.914841778378392 0.1877968806565 no 2751 0.180137349300204 3941 6758089
SGTC_3225 9130819 49.47 µM -0.91632413084916 0.187415168983044 no 2752 0.179748457564419 3932 4547121
SGTC_1319 1306-0155 43.7 µM -0.917095173019929 0.187216812283069 no 2753 0.179546385126206 4025 3122360
SGTC_419 nsc-638432 893 µM -0.918207786382882 0.186930812612806 no 2754 0.179255046502009 3967 368090
SGTC_741 4582-0002 126 µM -0.918832283082325 0.186770402903282 no 2755 0.179091651926936 3959 2912688
SGTC_1970 st070122 35.8 µM -0.921408016009754 0.186109694844189 no 2756 0.178418722618804 4022 102928
SGTC_2077 5212015 200 µM -0.923016145772341 0.185697924784897 no 2757 0.177999395623382 3860 780900
SGTC_414 piperonyl butoxide 100 µM -0.926610190668037 0.184779695907462 no 2758 0.17706448096566 3993 5794 A potent inhibitor of cytochrome P450.
SGTC_1653 st012112 65 µM -0.927430200993992 0.184570590681681 no 2759 0.176851608086961 3995 720429
SGTC_3327 9140648 26.9345 µM -0.92894455449267 0.184184812758774 no 2760 0.176458910646886 4017 8029710
SGTC_3217 9129673 49.47 µM -0.930299149537536 0.183840158482628 no 2761 0.176108109022393 4038 17248312
SGTC_442 cape 100 µM -0.93458039188804 0.182753510696363 no 2762 0.175002293999505 3964 5281787
SGTC_2765 myclobutanil 7.74 µM -0.939475334923986 0.181516020165839 no 2763 0.173743375050966 4061 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2736 butenafine 14.65 µM -0.941047532701292 0.181119668293487 no 2764 0.173340250549647 3965 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_591 4299-0174 154 µM -0.94175771906381 0.180940807845072 no 2765 0.173158348304098 4011 5509088
SGTC_2741 miltefosine 3.04 µM -0.946160830900809 0.179834356045022 no 2766 0.172033280449527 3991 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_603 3794-0023 45.9 µM -0.946725262138711 0.179692828861581 no 2767 0.171889397112627 4052 3802260
SGTC_3177 9107506 49.47 µM -0.949783807010863 0.178927137736104 no 2768 0.171111057735696 3971 8897194
SGTC_1683 st010134 710 nM -0.94991642306846 0.178893984493041 no 2769 0.171077360627798 4022 3818134
SGTC_3042 9091578 49.47 µM -0.950046255592633 0.178861530862723 no 2770 0.171044374914462 4005 25236497
SGTC_1825 st052143 62.6 µM -0.953369201491168 0.178032171017789 no 2771 0.17020152019092 4072 674173
SGTC_2718 lomofungin 53.02 µM -0.953579975305564 0.177979646787674 no 2772 0.170148147982972 4020 5351222 A RNA synthesis inhibitor.
SGTC_2256 7954252 200 µM -0.955034925629943 0.1776173439144 no 2773 0.169780017613017 4070 2972920
SGTC_2025 5147754 141 µM -0.95616172828317 0.177337074407862 no 2774 0.169495266141058 4014 315777 YLR208W SEC13
SGTC_3285 9112818 20.8695 µM -0.956590052134665 0.177230610748916 no 2775 0.169387105924306 4019 17017947 YPR165W RHO1
SGTC_2211 7117706 200 µM -0.957510781267982 0.177001892109349 no 2776 0.169154753658742 3970 822771
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.958298630905628 0.17680633025055 no 2777 0.168956096998708 4099 5377381
SGTC_1044 1222-0021 1.78 µM -0.959019433725228 0.176627530595716 no 2778 0.168774477557967 4011 4306703
SGTC_3324 9138759 60.749 µM -0.960154945538312 0.176346091805995 no 2779 0.168488619198879 4077 45595710
SGTC_515 4092-1064 102 µM -0.960468546934783 0.176268415125123 no 2780 0.168409726800122 4078 717353
SGTC_2048 5246248 200 µM -0.960985904054448 0.176140317033029 no 2781 0.168279627701807 4056 677046
SGTC_1434 4073-0095 163 µM -0.964472826460924 0.175278489455538 no 2782 0.167404462816838 3978 24133745
SGTC_567 1080-0542 68.4 µM -0.96691369218983 0.174676798986342 no 2783 0.166793590613908 3918 5950415
SGTC_827 3253-0474 693 µM -0.971862936510542 0.173460806412159 no 2784 0.165559370287941 4100 5402065
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.971883202601527 0.173455838286402 no 2785 0.165554328594985 3869 4000243
SGTC_3107 9121808 49.47 µM -0.975951939829368 0.172460243404999 no 2786 0.164544140646243 3936 662681
SGTC_2379 9035213 200 µM -0.977531242242232 0.172074781725762 no 2787 0.164153109227395 4047 646551
SGTC_1245 0418-0076 17.2 µM -0.978395970857271 0.171863959845194 no 2788 0.163939260095461 4128 6790114
SGTC_1060 3448-7350 82 µM -0.978568346456805 0.171821954190859 no 2789 0.163896652880103 4030 570178
SGTC_507 nimesulide 162 µM -0.979132666562178 0.171684482715945 no 2790 0.163757216427245 4128 4495 A COX2 inhibitor.
SGTC_651 3253-0966 34.4 µM -0.982208911793678 0.170936328409943 no 2791 0.162998469035402 4076 781462
SGTC_929 2805-0021 398 µM -0.984551796085195 0.170367931629309 no 2792 0.162422138667575 4134 3098024
SGTC_1943 st076331 65.2 µM -0.9859285166148 0.170034496915619 no 2793 0.162084096074086 4088 24208415
SGTC_2794 7785382 27.27 µM -0.987256888912994 0.169713168676724 no 2794 0.161758359656265 4031 2205081
SGTC_801 0866-0028 10.1 µM -0.989102926604192 0.169267266290901 no 2795 0.161306392944297 4069 6849771
SGTC_51 1013-0126 23.419 µM -0.989883861586697 0.169078861419555 no 2796 0.161115444250113 4038 1627850
SGTC_2907 7721985 69.9 µM -0.991288967761457 0.168740211095266 no 2797 0.160772249218478 4116 3267881
SGTC_1033 k072-0102 21.3 µM -0.991302740368392 0.168736893862234 no 2798 0.160768887644378 4062 5965931
SGTC_2403 6032726 181.2 µM -0.991964312597811 0.16857759871375 no 2799 0.160607467249686 4144 2881040
SGTC_1277 0873-0036 22 µM -0.992316092940818 0.168492935474426 no 2800 0.160521677688808 4156 5965735
SGTC_2962 9082311 13.18 µM -0.992740461081492 0.168390838864198 no 2801 0.160418225805279 4083 16459453
SGTC_1689 st020265 53.493 µM -0.995446763217512 0.167740679281144 no 2802 0.159759512190268 4081 5758320 YPR016C TIF6
SGTC_1133 3473-0247 50 µM -0.998473996629512 0.167015337478062 no 2803 0.159024783809477 4076 711311
SGTC_1699 st031318 29.054 µM -1.00088549489086 0.166438978818158 no 2804 0.158441084955912 4132 5340658
SGTC_1393 3470-5649 58.2 µM -1.00535499832538 0.165374147809567 no 2805 0.157362970467405 4063 4108395
SGTC_2040 5100729 123 µM -1.00667551295153 0.165060388900652 no 2806 0.157045366593009 4107 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2433 5607874 27.82 µM -1.00679104048702 0.165032957498108 no 2807 0.157017600532617 4060 2252428
SGTC_714 4296-0578 26.1 µM -1.01248190627543 0.163685345821772 no 2808 0.155653846813961 4132 1589775
SGTC_1981 st071826 47 µM -1.01336048636529 0.16347793416742 no 2809 0.155444002926183 4125 11838600
SGTC_2598 perillyl alcohol 100 µM -1.0140153296081 0.163323452480918 no 2810 0.155287718785843 4144 10819 An apoptosis inducer.
SGTC_3215 9129942 49.47 µM -1.01437189830296 0.163239375549999 no 2811 0.155202664131903 4095 17682944
SGTC_648 0375-0473 33.3 µM -1.01543992581335 0.162987708863354 no 2812 0.154948084612396 4077 1713139
SGTC_3194 9111903 49.47 µM -1.01650747956015 0.162736406014535 no 2813 0.154693893783915 4154 17087251
SGTC_596 1155-0152 116 µM -1.02075470918858 0.161739102641823 no 2814 0.153685333593133 4100 280313
SGTC_2303 7774051 200 µM -1.022016531135 0.16144357993159 no 2815 0.15338653817412 4161 2953184
SGTC_2002 4023503 131 µM -1.02298193675952 0.161217716766829 no 2816 0.153158193212258 4112 4736863 YCR052W RSC6
SGTC_2583 asiatic acid 100 µM -1.0238787496286 0.161008086124047 no 2817 0.152946274269441 4156 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1519 esterone 74 µM -1.02483389334596 0.160785016325718 no 2818 0.152720785500959 4085 698 A steroid.
SGTC_1143 3454-2408 5.08 µM -1.02517089388732 0.16070635944871 no 2819 0.152641279615462 4092 X1143
SGTC_2886 9058944 51.95 µM -1.0255347347225 0.160621466186403 no 2820 0.152555472341913 3970 4949929
SGTC_2415 st077333 57.7 µM -1.02630474230677 0.160441900561915 no 2821 0.152373981321593 4174 2766255
SGTC_3174 9107204 49.47 µM -1.02707495795492 0.16026241768294 no 2822 0.15219258468754 4162 3938802
SGTC_1925 st057770 10.1 µM -1.02792847994318 0.16006367533142 no 2823 0.151991735788029 4110 5989122
SGTC_2652 actinonin 100 µM -1.02843475825242 0.159945864749408 no 2824 0.151872682727227 4119 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2768 sulfasalazine 50.2 µM -1.02929045847906 0.159746872911292 no 2825 0.151671602805933 4055 5384001 An antioxidant and salicylic acid derivative.
SGTC_2953 9074162 66.49 µM -1.03128290684621 0.159284159898492 no 2826 0.151204085835032 4122 16451992
SGTC_2683 piperine 63.03 µM -1.03241191898829 0.159022355567197 no 2827 0.150939595357927 4101 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_167 3672-0051 66.205 µM -1.03576641607338 0.158246152328102 no 2828 0.150155564456897 4038 3237971
SGTC_2425 5628681 7.85 µM -1.03712710278028 0.157932010495767 no 2829 0.149838312805225 4200 5714958
SGTC_566 0958-0068 16.5 µM -1.0402703820352 0.157207887978712 no 2830 0.149107150224859 4046 6815365
SGTC_1282 0886-0010 32.4 µM -1.04133388815656 0.156963381348284 no 2831 0.148860307024421 4187 2836211 YNL267W PIK1
SGTC_916 4466-0038 42 nM -1.04194560797689 0.156822856573506 no 2832 0.148718448656124 4205 5722064 YGL116W CDC20
SGTC_2971 9092186 9.93 µM -1.04256396645563 0.156680890924985 no 2833 0.148575142642474 4149 25236400
SGTC_3116 9124943 49.47 µM -1.04476094237325 0.156177183246096 no 2834 0.148066735323044 4120 41905195 YPL160W CDC60
SGTC_446 go6976 132 µM -1.04477233637829 0.156174573690324 no 2835 0.148064101648214 4157 3501 A protein kinase C inhibitor.
SGTC_2367 9070478 135.38 µM -1.045051595269 0.156110624330959 no 2836 0.147999561967844 4092 572802
SGTC_2350 9023895 38.85 µM -1.04795354516694 0.15544710885553 no 2837 0.147330005266189 4169 2997209
SGTC_1409 3909-8004 61.9 µM -1.05126656680118 0.154691882058486 no 2838 0.146568088887151 4156 2119279
SGTC_1927 st060202 13.8 µM -1.05144812328427 0.154650565160583 no 2839 0.146526411773687 4013 688887
SGTC_1168 k815-0004 80.5 µM -1.05984817200553 0.152746935795097 no 2840 0.144606838701117 4137 642433
SGTC_772 k072-0172 35.3 µM -1.06332563588513 0.151963436744075 no 2841 0.143817151680672 4190 5861980
SGTC_562 3772-2733 112 µM -1.06449962591852 0.151699531689176 no 2842 0.143551211887374 4148 2876874 YIL048W NEO1
SGTC_1656 st012921 11 µM -1.06532059097184 0.151515165354398 no 2843 0.143365438934688 4075 6732821
SGTC_2258 7960471 200 µM -1.06610870110966 0.151338317539546 no 2844 0.143187253377074 4206 2974708
SGTC_713 1488-1073 324 µM -1.06705579806508 0.151125975594753 no 2845 0.142973320117771 4109 3312542
SGTC_3017 9080681 49.47 µM -1.06901909751158 0.150686429694101 no 2846 0.142530532063646 4179 16451914
SGTC_80 0159-0065 512.242 µM -1.06926980319633 0.150630362752163 no 2847 0.142474056602957 4044 1548079
SGTC_1811 st050069 61.5 µM -1.07259310641357 0.149888463618353 no 2848 0.141726859539995 4120 3877702
SGTC_1221 2958-7315 257 µM -1.0726455729247 0.149876770490797 no 2849 0.141715084518966 4205 4562705
SGTC_2871 9038510 12.99 µM -1.07558030013966 0.149223681235714 no 2850 0.141057500851014 4122 4945164
SGTC_317 4495-0002 170 µM -1.0767081234166 0.148973203586757 no 2851 0.140805341043503 4193 15991618
SGTC_2149 5554786 194.827 µM -1.07727001783758 0.148848517656374 no 2852 0.140679826365366 4190 745063 YPR165W RHO1
SGTC_2273 7815444 169.05 µM -1.07732273885245 0.148836822296594 no 2853 0.140668053564453 4124 2824616
SGTC_2566 crystal violet carbinol 226 nM -1.07745426458372 0.148807647979376 no 2854 0.140638686288762 4215 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2940 9060638 45.86 µM -1.07774784763233 0.148742540782744 no 2855 0.140573149607312 4164 4027022
SGTC_3235 9132602 49.47 µM -1.07817919263987 0.148646916994512 no 2856 0.140476897867969 4182 4912240
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.08813629926746 0.146450974199391 no 2857 0.138267470524736 4178 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1032 k061-1018 98.7 µM -1.08833442593797 0.146407501419031 no 2858 0.138223749026085 4275 4005393
SGTC_3157 9099274 49.47 µM -1.0896368208239 0.146121946747906 no 2859 0.137936578357074 4219 17217662
SGTC_2498 4'-Methoxychalcone 54.63 µM -1.09002417860616 0.146037089418596 no 2860 0.137851246745666 4169 641818 YHR062C RPP1
SGTC_417 st075190 100 µM -1.09008680953991 0.146023372154193 no 2861 0.137837453068895 4188 222757
SGTC_618 k072-0232 33.2 µM -1.09161969566895 0.145687913278282 no 2862 0.137500147695573 4219 5872756 YGL099W LSG1
SGTC_2537 larixol 68.93 µM -1.09273826544839 0.145443451171612 no 2863 0.137254366871517 4180 6708759
SGTC_523 1934-0222 13.7 µM -1.09411744562225 0.145142412984538 no 2864 0.136951736014423 4130 1361595
SGTC_258 haloperidol 50.781 µM -1.09650921726025 0.144621347907911 no 2865 0.136427995945888 4173 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2780 5215298 71.43 µM -1.09747227720846 0.144411894491471 no 2866 0.136217496549358 4212 2834131
SGTC_1603 st002045 67.8 µM -1.09844596384993 0.144200337825788 no 2867 0.136004900498926 4192 5887985
SGTC_444 curcumin 90.4 µM -1.09954963907434 0.143960790800488 no 2868 0.135764197357407 4126 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1546 5-methoxyflavanone 78.7 µM -1.09975360771318 0.143916549859404 no 2869 0.135719745316676 4193 147795
SGTC_625 k213-0058 121 µM -1.0998767717718 0.143889839929804 no 2870 0.135692908303652 4258 3655420
SGTC_1063 disulfiram 1.84 µM -1.10043124056275 0.143769636668123 no 2871 0.135572136532844 4210 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2754 granisetron 64.02 µM -1.1032670453613 0.143155922266621 no 2872 0.134955606629137 4205 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2272 7805186 180 µM -1.10386816378446 0.143026058095551 no 2873 0.134825165409664 4206 2956062 YPR165W RHO1
SGTC_398 bronopol 33.3 µM -1.10495576923517 0.142791296792887 no 2874 0.134589377595949 4121 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2132 5317594 122.667 µM -1.10614462738343 0.142534978074393 no 2875 0.134331962627598 4155 794577
SGTC_3137 9097352 49.47 µM -1.10751382591685 0.142240163603882 no 2876 0.13403591899484 4238 44120435
SGTC_1096 rimcazole 32.2 µM -1.10965775687667 0.141779363928553 no 2877 0.133573266323676 4122 18528119 A dopamine reuptake inhibitor.
SGTC_1250 0485-0349 40.2 µM -1.10972579519868 0.141764756876512 no 2878 0.13355860189632 4219 6842794 YDL195W SEC31
SGTC_2918 7977171 22.06 µM -1.11017078833915 0.141669247055523 no 2879 0.133462718989067 4189 2236483
SGTC_1490 4089-0339 670 nM -1.11198216555025 0.141280917229786 no 2880 0.133072909256416 4177 742542
SGTC_1414 3917-0015 5.4 µM -1.11268861579227 0.141129661554826 no 2881 0.132921093260879 4192 6618702
SGTC_2618 avocadyne 43.43 µM -1.11550727561693 0.140527261150203 no 2882 0.132316551203283 4122 3015189
SGTC_119 0121-0043 24.815 µM -1.11598344291296 0.14042566788137 no 2883 0.132214610951942 4220 1092378
SGTC_2120 5538279 151.968 µM -1.11950685592099 0.139675475541789 no 2884 0.131461983849214 4173 2058197
SGTC_1191 1487-1166 10.6 µM -1.1213946367472 0.139274659212861 no 2885 0.131059959032677 4250 3955771
SGTC_1157 4092-0394 27.6 µM -1.12149223150758 0.139253959051314 no 2886 0.13103919821206 4293 3659885
SGTC_3251 9135047 49.47 µM -1.12278996690836 0.138978904213406 no 2887 0.130763353743624 4242 17682963
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.12364537006546 0.138797804020787 no 2888 0.130581750305944 4246 61125 An anti-inflammatory.
SGTC_712 r015-0009 80.6 µM -1.12625143492813 0.138247056538872 no 2889 0.130029553930897 4245 6813872 YLR060W FRS1
SGTC_2103 5378138 10 µM -1.12661335360023 0.138170689165788 no 2890 0.129952995364426 4279 244142
SGTC_904 1141-0088 396 µM -1.13017691507924 0.137420288667739 no 2891 0.129200842514627 4229 1378119
SGTC_1146 3579-1023 7 µM -1.13509197769061 0.136389867789775 no 2892 0.12816839124392 4254 X1146
SGTC_638 3970-0837 4.09 µM -1.13579052645808 0.136243850285391 no 2893 0.128022121416663 4206 4118451 YLR208W SEC13
SGTC_1888 azatryptophan 97.5 µM -1.1400493717018 0.135355939158435 no 2894 0.12713286634213 4270 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1298 1079-1278 263 µM -1.14184746618267 0.134982254384739 no 2895 0.126758714158963 4205 2840950
SGTC_2522 biochanin a 4.94 µM -1.14186306193756 0.13497901633182 no 2896 0.126755472311086 4249 5280373 A possible chelator.
SGTC_3136 9095672 49.47 µM -1.14426572461445 0.134480802172306 no 2897 0.126256726640812 3980 17217380
SGTC_3152 9099253 49.47 µM -1.14541815655709 0.134242283378396 no 2898 0.12601799032286 4149 25236131
SGTC_739 1486-1183 203 µM -1.14768359245592 0.133774253594996 no 2899 0.125549603476451 4241 4346692
SGTC_115 0527-0192 112.043 µM -1.14958507184393 0.133382282567816 no 2900 0.125157404780868 4229 4233931
SGTC_1150 3909-7983 10.9 µM -1.15339381849835 0.132599525513538 no 2901 0.124374388769495 4218 23965914
SGTC_2757 clomiphene 4.22 µM -1.15420613245459 0.132432992551413 no 2902 0.124207834500662 4272 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_704 1310-0270 142 µM -1.15500829307537 0.132268682623655 no 2903 0.124043515209739 4265 5718033
SGTC_2826 7992541 19.48 µM -1.15518040138011 0.132233447274645 no 2904 0.124008279362599 4257 2985066
SGTC_1279 0874-0590 65.2 µM -1.15602854867863 0.132059902489424 no 2905 0.123834739913254 4307 3523074
SGTC_1057 3448-5381 134 µM -1.15624895917666 0.132014828626062 no 2906 0.123789669555873 4230 5497911
SGTC_2876 9059903 25.97 µM -1.15735494724813 0.131788814680903 no 2907 0.12356368639179 4243 6916095
SGTC_3065 9113888 49.47 µM -1.1582969393116 0.13159652473885 no 2908 0.123371439993965 4309 16648368
SGTC_1596 piperlongumine 63 µM -1.15959489187096 0.131331889523306 no 2909 0.123106890853365 4291 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1547 harmine 94.2 µM -1.16077757288572 0.131091076806131 no 2910 0.122866182842267 4201 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_2878 9043973 25.97 µM -1.16082522249372 0.131081380982573 no 2911 0.122856491761752 4290 6465167
SGTC_492 tmb-8 126 µM -1.16096285035144 0.131053379013179 no 2912 0.122828503719835 4212 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2818 7996756 12.99 µM -1.1674111502324 0.129746029275958 no 2913 0.121522185177046 4283 2241621
SGTC_1686 st019653 115.5 µM -1.16748674762105 0.129730756163926 no 2914 0.121506928539098 4251 97252
SGTC_2444 5485484 36.41 µM -1.16833949980321 0.129558558940118 no 2915 0.121334924161813 4329 6790631
SGTC_669 0108-0021 26.2 µM -1.16851110147638 0.129523926364239 no 2916 0.121300331950054 4223 17201
SGTC_1076 itraconazole 331 nM -1.17200317780418 0.128820550058019 no 2917 0.120597890155725 4256 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1349 flufenamic acid 69 µM -1.17272844273196 0.128674799646019 no 2918 0.120452360820321 4194 3371 A non-steroidal anti-inflammatory.
SGTC_3214 9129694 49.47 µM -1.17679669451197 0.127859358424732 no 2919 0.119638331137554 4297 17158655
SGTC_2758 dehydroepiandrosterone 69.35 µM -1.18271282082558 0.126679948418406 no 2920 0.118461490655422 4284 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1102 cgs 12066b 26.1 µM -1.18290904679369 0.126640960009443 no 2921 0.118422597919011 4276 6438352 A 5-HT1B full agonist.
SGTC_2099 5377090 177.372 µM -1.18463999250574 0.126297398002106 no 2922 0.118079908808535 4287 2243829
SGTC_1145 3546-0597 10.2 µM -1.18720421985988 0.125789639085019 no 2923 0.11757353839555 4243 875334
SGTC_284 0988-0104 32.6 µM -1.18741507782848 0.125747949210285 no 2924 0.117531967755974 4244 4666532
SGTC_693 4161-2696 114 µM -1.18789212375524 0.125653665440921 no 2925 0.117437956576882 4312 805759
SGTC_1000 4048-0884 8.67 µM -1.1886836288221 0.125497340522511 no 2926 0.117282092594366 4315 13040088
SGTC_2191 5911152 200 µM -1.18875138595803 0.125483964569451 no 2927 0.117268756601742 4279 2875902
SGTC_2305 7443522 69.23 µM -1.19751802793039 0.123761725732555 no 2928 0.115552352536891 4178 5415886
SGTC_1500 4488-1866 171 µM -1.19882872351413 0.123505663689057 no 2929 0.11529727564563 4347 2900003
SGTC_3328 9140624 29.0385 µM -1.20296572731079 0.12269987913694 no 2930 0.114494791744991 4295 4904392
SGTC_384 k007-0144 5.16 µM -1.20442290052991 0.122416938471956 no 2931 0.114213082584634 4214 6824886
SGTC_1419 3993-2473 62.6 µM -1.20729584247208 0.121860438739057 no 2932 0.113659115615907 4361 704026
SGTC_2091 4-phenylthiadiazole 200 µM -1.20893624155305 0.12154348547161 no 2933 0.113343670670861 4315 270010
SGTC_1189 1431-2119 7.28 µM -1.21446311800719 0.120479864741275 no 2934 0.112285462762166 4282 3107275
SGTC_257 daunorubicin 18.5 µM -1.21457785656928 0.120457853529339 no 2935 0.112263569309497 4311 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2394 5221648 200 µM -1.21460212117622 0.120453199019408 no 2936 0.112258939730983 4331 788586
SGTC_2824 7998404 51.95 µM -1.21477809325234 0.120419447316383 no 2937 0.112225369128324 4248 837851
SGTC_383 2324-0395 7.37 µM -1.21614792964431 0.120156938417816 no 2938 0.111964287547734 4295 3146421
SGTC_1372 2752-0194 270 µM -1.21697889054261 0.119997893678886 no 2939 0.111806123787229 4233 823334
SGTC_3056 9094900 49.47 µM -1.21929932949099 0.119554550861169 no 2940 0.111365301517235 4273 25236784
SGTC_3060 1327-0027 12.5 µM -1.2214536261747 0.119143986624707 no 2941 0.110957156815764 4221 16000455 YPR107C YTH1
SGTC_1065 prochlorperazine maleate 2.48 µM -1.22815728926546 0.117872778352829 no 2942 0.109693964241249 4347 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_301 4119-0100 24.5 µM -1.23585279548248 0.116425355055566 no 2943 0.108256643070975 4335 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_1024 4507-0395 26 µM -1.2368552696531 0.116237735106065 no 2944 0.108070409389741 4368 4201836
SGTC_753 1322-0200 289 µM -1.23713765290488 0.116184923885816 no 2945 0.108017991573239 4382 5403907
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.23743964279276 0.116128464684166 no 2946 0.107961954505106 4331 16486 A toxic proline analog.
SGTC_117 lucigenin 22.078 µM -1.23884321343153 0.115866312539403 no 2947 0.107701783497201 4307 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_40 0327-0103 19.753 µM -1.23954368034316 0.115735640016134 no 2948 0.107572111468358 4164 409036
SGTC_1931 st074438 57.1 µM -1.24388288057203 0.114928491913345 no 2949 0.106771335444344 4327 2787313
SGTC_2438 5259590 200 µM -1.24487162821015 0.114745133351882 no 2950 0.106589470700729 4334 1201127
SGTC_2436 5633522 8.09 µM -1.24496422555644 0.114727972277967 no 2951 0.106572450317691 4303 5724242
SGTC_1799 st045822 46.1415 µM -1.2450687787719 0.114708597616996 no 2952 0.106553234676316 4312 3674992
SGTC_189 3970-0742 2.116 µM -1.24599651962114 0.114536780784606 no 2953 0.106382836462342 4302 2891807
SGTC_1126 isoteolin 1.0172 µM -1.24744661570337 0.114268591250261 no 2954 0.106116891526683 4271 133323
SGTC_971 1315-0384 26.7 µM -1.24941396653384 0.113905452828941 no 2955 0.105756851351983 4357 6769120
SGTC_749 1000-0129 128 µM -1.25071342816262 0.113666046433468 no 2956 0.105519524762169 4379 708470
SGTC_2715 st079500 56.4 µM -1.25185182515275 0.113456608743941 no 2957 0.105311930856595 4299 28246688
SGTC_949 1165-0505 146 µM -1.25224394853604 0.113384531226535 no 2958 0.105240493133927 4302 6244267
SGTC_2087 5276107 200 µM -1.25707763447111 0.112498716772563 no 2959 0.104362762488969 4284 144405
SGTC_2018 5133068 143 µM -1.25716508154674 0.112482737000277 no 2960 0.104346932310102 4289 785362
SGTC_2063 5246145 200 µM -1.25818421809216 0.112296623115629 no 2961 0.104162570579802 4373 711240
SGTC_2053 5265679 138 µM -1.25900138948082 0.112147550986645 no 2962 0.104014914998101 4234 764595
SGTC_923 1900-2434 73.3 µM -1.25997906939223 0.111969384082996 no 2963 0.103838456449153 4316 5910570
SGTC_3201 9113999 49.47 µM -1.26006713237049 0.111953345921158 no 2964 0.103822572889659 4316 16649224
SGTC_1634 st006576 41 µM -1.26062558233452 0.111851678411374 no 2965 0.103721888574572 4312 3915356
SGTC_1957 st077035 62.4 µM -1.26244177263286 0.111521492061253 no 2966 0.103394933007263 4336 705593
SGTC_1572 epiandrosterone 68.9 µM -1.26268261671242 0.111477758649882 no 2967 0.103351631840882 4275 441302 A steroid.
SGTC_857 0438-0306 1.35 µM -1.26567441692972 0.110935518781116 no 2968 0.102814835594391 4404 4686136
SGTC_616 4092-0450 108 µM -1.2668779443585 0.110717922800892 no 2969 0.102599468095053 4343 787165
SGTC_956 1185-0240 191 µM -1.27172963325876 0.10984384651016 no 2970 0.101734598998326 4318 1416193
SGTC_1804 st050076 49.1 µM -1.2724059662704 0.109722393324947 no 2971 0.101614457667039 4359 3895976
SGTC_1187 1391-0724 117 µM -1.27785262626159 0.108747816932606 no 2972 0.100650697250109 4388 6997986
SGTC_2556 citropten 84.59 µM -1.28166132814782 0.108070030465805 no 2973 0.0999807382010405 4367 2775 A potential DNA crosslinker.
SGTC_2928 9011484 9.79 µM -1.28245065047417 0.107929946052015 no 2974 0.0998423029844137 4357 2994751
SGTC_1722 st034304 3.6505 µM -1.28350139955253 0.107743668081438 no 2975 0.099658234782243 4305 4036148 YLR033W RSC58
SGTC_1332 1480-0653 17.5 µM -1.28452455653834 0.107562504334791 no 2976 0.0994792384989883 4349 5749438
SGTC_487 nimodipine 119 µM -1.28642461673925 0.107226655570023 no 2977 0.0991474558914624 4352 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2317 5986382 200 µM -1.28670073349748 0.107177913017174 no 2978 0.0990993086655217 4375 877883
SGTC_1642 st009582 77.7 µM -1.291062927372 0.106409979438188 no 2979 0.0983409289557017 4331 6739311
SGTC_1608 st001473 40.5 µM -1.29333892590685 0.106010886768616 no 2980 0.0979469316206422 4305 7292267
SGTC_1193 1488-0126 41.5 µM -1.29394552503728 0.105904703365593 no 2981 0.097842118963893 4332 1384710
SGTC_2887 9044784 58.44 µM -1.29431849908382 0.105839453522095 no 2982 0.0977777145947099 4319 6465546
SGTC_2068 5226020 147 µM -1.29679329535294 0.105407236930206 no 2983 0.0973511591086956 4373 1810509
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -1.3002131626766 0.10481206944906 no 2984 0.0967639602590093 4359 75037 A free radical scavenger.
SGTC_2057 5236571 38.335 µM -1.30209052675363 0.104486383815795 no 2985 0.0964427205850568 4329 54684039 YBR257W POP4
SGTC_2381 9035592 200 µM -1.30245397107878 0.104423418199453 no 2986 0.096380621510433 4370 4749657
SGTC_2913 7966556 36.57 µM -1.30328136094318 0.104280177990783 no 2987 0.0962393610514565 4266 2976516
SGTC_83 0170-0301 39.027 µM -1.30634007031026 0.103751881479336 no 2988 0.0957184680915765 4376 3089716
SGTC_2089 5281248 129.67 µM -1.30650464588973 0.103723511333903 no 2989 0.0956905000721779 4358 2737878
SGTC_615 k087-0205 167 µM -1.30910094117457 0.103276696888785 no 2990 0.0952500802513022 4398 9642773
SGTC_82 0054-0107 293.755 µM -1.30987172909277 0.103144316075952 no 2991 0.0951196162266516 4327 3104697
SGTC_132 0417-1715 25.805 µM -1.31280837429845 0.102641084086771 no 2992 0.0946237637372583 4358 6769098
SGTC_1515 3460-0031 42.1 µM -1.31478639336619 0.102303132386526 no 2993 0.0942908508172437 4336 2876596
SGTC_2975 9084847 53.72 µM -1.31600236642794 0.102095781074097 no 2994 0.0940866242025644 4388 27211724
SGTC_3313 9133968 57.047 µM -1.31693878086823 0.101936309450029 no 2995 0.0939295729401091 4368 1494643
SGTC_3128 9127691 49.47 µM -1.31732123293755 0.101871229928173 no 2996 0.0938654854565757 4408 41316314
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -1.31807389159889 0.101743242951252 no 2997 0.0937394567297805 4378 115019
SGTC_595 3909-8003 73.7 µM -1.31889017797294 0.101604568673077 no 2998 0.0936029151350843 4436 699517
SGTC_3150 9097574 49.47 µM -1.32203126859621 0.10107223036924 no 2999 0.0930788694517389 4416 17217476
SGTC_1512 0259-0544 12.2 µM -1.32347000746571 0.100829079158777 no 3000 0.0928395620009925 4346 18476
SGTC_2061 5245884 80.95 µM -1.32445373999713 0.100663071095355 no 3001 0.0926761984619827 4360 573863
SGTC_1904 st060225 78 µM -1.32716477689135 0.100206606723143 no 3002 0.0922270906105871 4345 66595
SGTC_869 0564-0080 44.1 µM -1.33040590361536 0.0996628749908892 no 3003 0.0916922852523313 4382 6843321
SGTC_812 4251-0442 148 µM -1.33403331419519 0.0990569002389021 no 3004 0.0910964693788434 4409 5723007
SGTC_3183 9108214 49.47 µM -1.33413891720533 0.0990392992556502 no 3005 0.0910791668016504 4372 4974831
SGTC_533 1222-0222 6.71 µM -1.3372337022541 0.098524503044365 no 3006 0.0905731820406315 4406 3982874
SGTC_1317 1273-0028 910 nM -1.33738828967803 0.0984988399581858 no 3007 0.0905479624548901 4402 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1422 4031-0024 15.5 µM -1.33759295764146 0.0984648705222909 no 3008 0.0905145806876664 4340 782427
SGTC_350 k064-0020 19.8 µM -1.33863387352924 0.0982922389261809 no 3009 0.0903449465456926 4417 2790705
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.33905489292554 0.0982224775993592 no 3010 0.0902764016984036 4351 688761
SGTC_991 3996-0057 64.7 µM -1.3397424689918 0.0981086268283037 no 3011 0.0901645426553588 4426 715343
SGTC_431 k089-0097 107 µM -1.3401301461736 0.0980444767953664 no 3012 0.0901015183907209 4138 5499420
SGTC_3306 9127676 59.7925 µM -1.34259231732366 0.0976377717619798 no 3013 0.0897020097025143 4361 41905287
SGTC_2761 levamisole 97.89 µM -1.34401496511471 0.097403341328999 no 3014 0.0894717738442336 4404 26879 An alkaline phosphatase inhibitor.
SGTC_1891 st059073 26.2 µM -1.34457424254113 0.0973112941825354 no 3015 0.0893813829868658 4471 688754
SGTC_3230 9131665 49.47 µM -1.34510217124579 0.0972244650481918 no 3016 0.0892961210762511 4397 15943720
SGTC_1994 st072947 40.9 µM -1.34658263016339 0.0969812752787751 no 3017 0.0890573457492839 4440 5286565 YDL195W SEC31
SGTC_702 1488-0190 94 µM -1.34827025266977 0.0967046004691164 no 3018 0.0887857380963403 4432 949357
SGTC_1882 5615643 20 µM -1.35243767319334 0.0960238629347685 no 3019 0.0881176722814341 4348 2253075
SGTC_3002 9075603 71.4286 µM -1.35272173419996 0.095977590892508 no 3020 0.0880722721695567 4350 20105405
SGTC_1561 5-methoxyflavone 52.9 µM -1.35352561040892 0.0958467325551755 no 3021 0.0879438869924807 4368 94525
SGTC_1552 6-methylflavone 10.6 µM -1.35353880011164 0.0958445865749291 no 3022 0.0879417816604696 4353 689013
SGTC_1708 st033234 31.827 µM -1.35392358033911 0.095781997929826 no 3023 0.0878803798244198 4495 674664
SGTC_1100 amiodarone 5.07 µM -1.35565548606989 0.0955006570297852 no 3024 0.0876044043802794 4446 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -1.35755415766029 0.095192925110329 no 3025 0.0873025988020526 4358 676296 Flavone; oxidizing agent.
SGTC_2487 5918373 44.05 µM -1.35795976881804 0.0951272794373105 no 3026 0.0872382251481768 4457 2876279
SGTC_2417 cerulenin 830 nM -1.35915834938412 0.0949334913694278 no 3027 0.0870482081688718 4416 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_1508 1080-0625 72.9 µM -1.36360595314526 0.0942169388739773 no 3028 0.0863458087333062 4324 767111
SGTC_2932 9016711 44.54 µM -1.36770440714545 0.0935601770925821 no 3029 0.0857023099443073 4406 7117328
SGTC_1366 1683-0113 21.9 µM -1.36809034202091 0.0934985070908257 no 3030 0.0856418997121409 4399 708623
SGTC_464 bw-b 70c 158 µM -1.36864143252188 0.0934104982937751 no 3031 0.0855556930103746 4423 5353454
SGTC_1292 0kpi-0043 232 µM -1.36990631909348 0.0932087281659268 no 3032 0.0853580734476503 4441 3333905
SGTC_32 0928-0142 34.1 µM -1.37315657555277 0.0926917363269622 no 3033 0.0848518380459305 4408 2244242
SGTC_1691 st019933 84.6 µM -1.37433869980369 0.0925042323526034 no 3034 0.0846682786049485 4398 6176082
SGTC_1767 st044992 70.3 µM -1.3746532220043 0.0924543913549507 no 3035 0.0846194900107055 4463 9600693
SGTC_1525 8-methoxypsoralen 92.5 µM -1.37466237664175 0.0924529409560659 no 3036 0.0846180702618251 4464 4114 Related to psoralen; DNA damaging agent.
SGTC_1278 0874-0585 172 µM -1.37490842127897 0.0924139656132273 no 3037 0.0845799190701424 4475 766306
SGTC_2759 disulfiram 3.38 µM -1.37666508629111 0.0921360497268152 no 3038 0.0843079089160953 4333 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1785 bathophenanthroline 24 µM -1.37715872422908 0.0920580644564713 no 3039 0.0842315900165677 4341 72812 An iron chelator.
SGTC_1184 1269-1718 139 µM -1.37943365928152 0.0916993001530971 no 3040 0.0838805436731427 4466 5403821
SGTC_3355 9151058 44.0485 µM -1.38154264711031 0.0913676324854518 no 3041 0.0835560872384526 4440 17015728
SGTC_408 cantharidin 100 µM -1.38575724150465 0.0907074946304366 no 3042 0.0829105214032308 4402 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_841 0251-0215 91.2 µM -1.38653354104243 0.0905862887578143 no 3043 0.0827920228898652 4465 3888614
SGTC_1548 st061468 90.8 µM -1.38794985843113 0.0903654648938527 no 3044 0.0825761570353128 4458 390799
SGTC_1842 st055362 61.2 µM -1.38869646593624 0.0902492192753325 no 3045 0.0824625346539617 4378 676032
SGTC_225 nsc-122657 1.016 µM -1.39004874513806 0.0900389543546052 no 3046 0.0822570379150685 4442 275685
SGTC_888 0916-0002 6.97 µM -1.39261974209042 0.0896401961310322 no 3047 0.0818674049200389 4450 2802138 YIL048W NEO1
SGTC_3331 9141060 1.957 µM -1.39298883192088 0.0895830587379791 no 3048 0.0818115839481782 4387 4906567 YPR165W RHO1
SGTC_1275 0867-0008 21.1 µM -1.39306541137896 0.089571207156499 no 3049 0.0818000057014485 4404 3422836
SGTC_2648 atorvastatin 78.68 µM -1.39376394459125 0.0894631546578109 no 3050 0.0816944496633074 4434 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2294 7971431 200 µM -1.39588232986914 0.0891360653964955 no 3051 0.0813749662788626 4417 5741572
SGTC_2912 7964298 10.93 µM -1.39901530030588 0.0886539517264068 no 3052 0.0809041974727846 4437 2975850
SGTC_490 phenamil 164 µM -1.39993845571228 0.0885122641104037 no 3053 0.0807658745009875 4435 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1778 st046819 58.9 µM -1.40148924515941 0.0882746258949007 no 3054 0.0805339107024337 4479 671715
SGTC_79 0052-0007 94.094 µM -1.40652995713075 0.0875054874228485 no 3055 0.0797834077160655 4422 2801472
SGTC_1182 1222-0449 220 µM -1.40754214060724 0.0873516479057065 no 3056 0.0796333452839657 4437 658318
SGTC_1198 1612-1005 86.7 µM -1.40824068226552 0.0872455959194505 no 3057 0.0795299067884217 4506 6998509
SGTC_1425 4048-4433 7.33 µM -1.41137836307094 0.0867704214404317 no 3058 0.0790665396776221 4504 23734946
SGTC_2301 7769476 200 µM -1.41417738272821 0.0863481686624211 no 3059 0.0786549134820205 4426 977820
SGTC_1883 5-benzylidenerhodanine 20 µM -1.41551227007399 0.0861473330337129 no 3060 0.0784591767050739 4427 1273210
SGTC_846 0335-0850 148 µM -1.41725568526993 0.0858855603060798 no 3061 0.0782040931820191 4427 6819598
SGTC_3350 9150499 3.57 µM -1.41978582652506 0.0855067206579839 no 3062 0.0778350212430626 4456 4910996 YPR165W RHO1
SGTC_278 4092-0821 23.9 µM -1.42356562814363 0.0849431018049906 no 3063 0.0772861258166679 4453 877900
SGTC_3269 9137823 49.47 µM -1.42621699289642 0.0845494129930223 no 3064 0.0769028580277462 4382 17682936
SGTC_1328 1441-0025 69.2 µM -1.42904749316278 0.0841306374591431 no 3065 0.0764952917149387 4436 4562601
SGTC_993 3909-8757 62.7 µM -1.42991476160797 0.0840026363167038 no 3066 0.0763707423793823 4407 4288324 YLR208W SEC13
SGTC_1224 0823-0416 294 µM -1.43553985958396 0.0831759694627936 no 3067 0.0755666591955556 4478 3598164
SGTC_2462 5162487 171.77 µM -1.43634634251711 0.0830579515016815 no 3068 0.0754519066609736 4422 2259986
SGTC_1622 st003707 19.4 µM -1.44144948342203 0.0823140933795046 no 3069 0.0747288695722761 4467 10140899
SGTC_2960 9079389 5.97 µM -1.44521775458048 0.0817680403124823 no 3070 0.0741983654458356 4439 16457355
SGTC_3143 9086658 49.47 µM -1.44712964442834 0.0814920381982278 no 3071 0.0739303083694421 4456 25236626
SGTC_438 sphingosine 6.67 µM -1.44858505697287 0.0812824049715039 no 3072 0.0737267483728986 4388 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_3267 9137951 49.47 µM -1.45338491766767 0.0805939305354628 no 3073 0.0730584558503308 4506 16643986
SGTC_1978 st071761 42 µM -1.45565963239972 0.0802691961585237 no 3074 0.0727433671731539 4471 5147680
SGTC_334 1502-1024 68.5 µM -1.45845987065936 0.0798707980318 no 3075 0.0723569142493899 4472 3296216
SGTC_2813 7971799 71.43 µM -1.46351870473363 0.0791548565966147 no 3076 0.0716627496253758 4465 2234054
SGTC_2261 9010538 184.68 µM -1.46668790849672 0.0787088234827224 no 3077 0.07123048681805 4457 6457250
SGTC_2107 5363541 170.161 µM -1.46934143257358 0.0783368341645168 no 3078 0.0708701020917177 4418 244052
SGTC_2005 4024620 188 µM -1.46982795819185 0.0782687745046875 no 3079 0.0708041775059822 4434 236743
SGTC_2514 salinomycin 42.74 µM -1.47187075271823 0.0779834990481647 no 3080 0.0705278914479418 4512 23682228 A polyether potassium ionophore.
SGTC_1768 st044301 37.178 µM -1.47380711556912 0.077713815738853 no 3081 0.0702667659675017 4494 3931349
SGTC_1052 3253-3998 198 µM -1.47470519876053 0.0775889774618695 no 3082 0.0701459088981267 4429 5450317
SGTC_323 4013-0906 34.3 µM -1.47718906019402 0.0772445006181051 no 3083 0.0698124827276069 4499 2910086
SGTC_2938 9059746 27.26 µM -1.48212623792317 0.0765632349870313 no 3084 0.0691533542772274 4478 6471769
SGTC_111 0083-0039 52.457 µM -1.48493397532418 0.0761778480214472 no 3085 0.0687806574419047 4454 759313
SGTC_537 1334-0398 209 µM -1.48730046819546 0.0758541739874971 no 3086 0.0684677354640629 4507 5846986
SGTC_2148 5546263 113.568 µM -1.49286850343822 0.0750967453997716 no 3087 0.0677358056058118 4510 792097
SGTC_479 n-linoleoylglycine 10 µM -1.49295377875567 0.0750851902707451 no 3088 0.0677246431645903 4523 6433346 An anti-infammatory.
SGTC_1345 1488-0192 31.4 µM -1.49380879440667 0.0749694073467407 no 3089 0.0676128011328565 4531 658348
SGTC_777 1315-0167 517 µM -1.49596321725056 0.0746782676254278 no 3090 0.0673316203648068 4521 4221767
SGTC_2184 6075246 200 µM -1.49752036293957 0.0744683791920273 no 3091 0.067128955574119 4480 2267320
SGTC_2446 5162541 200 µM -1.50018528784004 0.0741102179443849 no 3092 0.0667832065680468 4474 1549321
SGTC_3257 9139206 32.98 µM -1.50084235229259 0.0740221121771969 no 3093 0.0666981707342129 4488 4910041
SGTC_2978 9011784 42.97 µM -1.50218754760866 0.0738419846011178 no 3094 0.0665243399212607 4478 2994934
SGTC_2299 7976368 114.88 µM -1.5028108232823 0.0737586388929504 no 3095 0.0664439170583176 4497 2979718
SGTC_642 0335-0876 158 µM -1.50359810541987 0.0736534647012285 no 3096 0.0663424396343044 4536 6812350
SGTC_50 0929-0078 56.389 µM -1.50438293197267 0.0735487327092519 no 3097 0.0662413982174609 4344 1377751
SGTC_2645 abamectin 100 µM -1.50898393996285 0.0729370356811058 no 3098 0.0656514434989037 4448 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2970 9090938 41.86 µM -1.5117190353464 0.0725752588757195 no 3099 0.0653026769976616 4533 17217104
SGTC_2848 9016370 25.97 µM -1.51436033476177 0.0722271947576763 no 3100 0.064967236839242 4473 7894410
SGTC_3191 9110352 49.47 µM -1.51549385590123 0.0720782149674222 no 3101 0.0648236925528525 4453 17122424
SGTC_1264 0783-0040 158 µM -1.51738739581099 0.0718298707723082 no 3102 0.0645844521539765 4422 2855798
SGTC_478 N-arachidonylglycine 10 µM -1.52449426130277 0.070903631944668 no 3103 0.0636926446603054 4540 5283389
SGTC_1558 st069300 45.6 µM -1.52711493143425 0.0705644046297918 no 3104 0.0633662173296813 4461 24208000
SGTC_2152 5568786 200 µM -1.53401723765923 0.069676919405016 no 3105 0.0625127060715646 4538 5399883
SGTC_746 1095-0025 46.6 µM -1.53975423948808 0.068945826912221 no 3106 0.0618101350662328 4531 6749286
SGTC_1788 fluconazole 20 µM -1.54041396049099 0.0688621361241864 no 3107 0.0617297403064735 4520 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_220 paclitaxel 373.376 µM -1.54377387044416 0.0684371198046075 no 3108 0.0613215617382445 4491 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1798 st045719 60.953 µM -1.54399232070801 0.0684095568701442 no 3109 0.0612950964942083 4484 3980186
SGTC_1457 k015-0032 57.3 µM -1.54515757848414 0.0682626752897891 no 3110 0.0611540762767514 4506 4302660
SGTC_534 k292-0788 63.4 µM -1.54916938362184 0.067758845306342 no 3111 0.0606705036273423 4567 4146317
SGTC_667 1498-1044 59 µM -1.55113996550612 0.067512420432582 no 3112 0.0604340727038273 4512 6739982
SGTC_2461 5755302 26.15 µM -1.55280238739963 0.0673050705844241 no 3113 0.0602351760916719 4532 2788904
SGTC_2478 5763493 32.33 µM -1.55438942424075 0.0671075829797288 no 3114 0.0600457771807785 4470 1365576 YLR208W SEC13
SGTC_1219 1469-0211 33.1 µM -1.55572953433798 0.0669411716417133 no 3115 0.0598862102229341 4520 6822282
SGTC_1924 st058459 75.1 µM -1.55734305686185 0.0667412324204586 no 3116 0.0596945289468236 4487 688683
SGTC_1483 3453-0561 55.9 µM -1.5592065625992 0.0665108919849576 no 3117 0.0594737490463393 4553 4546991
SGTC_926 2268-1401 59.4 µM -1.56077251638941 0.0663178070075967 no 3118 0.0592887171358093 4493 2931578
SGTC_761 k216-0224 480 µM -1.56114499613081 0.0662719435382065 no 3119 0.0592447717335112 4527 1340404
SGTC_2284 7945075 39.21 µM -1.56432655787774 0.0658811978939667 no 3120 0.0588704491339544 4485 1245402
SGTC_1522 st012842 45.6 µM -1.5662881328095 0.0656411769900099 no 3121 0.0586405889742398 4367 3491067 YOR116C RPO31
SGTC_2897 9048598 12.99 µM -1.56811001418411 0.0654188569677411 no 3122 0.0584277299329494 4518 6467404
SGTC_2674 ligustilide 100 µM -1.57340767463539 0.0647757131055183 no 3123 0.0578122255375657 4581 5319022 A signalling regulator.
SGTC_2416 tofa 880 nM -1.57445747737696 0.0646488503128699 no 3124 0.0576908623963619 4482 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_449 xestospongin c 11.1929 µM -1.57610640560711 0.0644499762537634 no 3125 0.0575006415330759 4554 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1087 pterostilbene 9.05 µM -1.57803717559398 0.0642177143011419 no 3126 0.0572785347789567 4535 5281727 Similar to reservatol, lowers cholesterol.
SGTC_3031 9088762 49.47 µM -1.58001514444051 0.0639804497295164 no 3127 0.0570516991473657 4514 205253
SGTC_1975 st070967 30.8 µM -1.58071076249613 0.063897170015776 no 3128 0.0569720932081215 4530 261391
SGTC_2551 apiole 73.87 µM -1.58198935449268 0.0637443163094038 no 3129 0.0568260003675359 4473 10659 A possible DNA adduct former.
SGTC_333 3486-0131 40.1 µM -1.58467328505085 0.0634243819082178 no 3130 0.0565202923332203 4546 6744690
SGTC_1793 st048256 72.231 µM -1.59468325281071 0.0622421700707206 no 3131 0.0553915424577429 4518 672022
SGTC_2623 humulene 100 µM -1.59478035208179 0.062230787066874 no 3132 0.0553806811081911 4525 6187145 An anti-inflammatory.
SGTC_1628 st004252 77.7 µM -1.59565374413778 0.0621284717872429 no 3133 0.055283060624419 4532 692968
SGTC_2034 5197015 53.07 µM -1.59787917832315 0.0618683620055541 no 3134 0.0550349344124898 4545 780676
SGTC_1898 st060199 18.6 µM -1.60274969545599 0.0613020598989512 no 3135 0.0544949635071341 4542 688866
SGTC_2944 9067346 25.62 µM -1.60348739094886 0.0612166412530002 no 3136 0.0544135453670957 4471 6473075
SGTC_3352 9151559 45.5865 µM -1.60800731445872 0.060695303016714 no 3137 0.0539167884131906 4547 17159339
SGTC_2839 9003951 25.97 µM -1.61654135339997 0.059720442245762 no 3138 0.0529886600150875 4605 2990634
SGTC_3158 9100007 49.47 µM -1.61674619562198 0.0596971943599325 no 3139 0.0529665388918015 4565 19297233
SGTC_78 0336-0123 156.75 µM -1.62542549097016 0.0587186663254475 no 3140 0.0520359640133782 4422 6765896
SGTC_2485 5633444 17.78 µM -1.62744880096898 0.0584923722009593 no 3141 0.0518209070551229 4522 5724239
SGTC_2136 5328288 199.296 µM -1.62819805987293 0.0584087464022926 no 3142 0.0517414480257513 4533 262395
SGTC_2868 9035608 32.47 µM -1.63386867346984 0.057778882447386 no 3143 0.051143214386531 4555 6462614
SGTC_226 1,3-diallylurea 8.28947 mM -1.63402276036557 0.0577618420532001 no 3144 0.0511270357948551 4540 74537 YKL182W FAS1
SGTC_759 3486-0358 89.3 µM -1.63895615987256 0.0572183454957831 no 3145 0.0506111951569111 4535 875103
SGTC_223 busulfan 5 mM -1.64310133739526 0.0567648033357061 no 3146 0.050180984109272 4555 2478 A DNA alkylator.
SGTC_174 3553-0389 74.3 µM -1.64653917514591 0.0563908065130267 no 3147 0.0498264007512689 4586 738071
SGTC_3200 9114385 49.47 µM -1.64763136717696 0.0562723960901213 no 3148 0.0497141698238952 4530 17018030 YLR208W SEC13
SGTC_579 4491-1009 110 µM -1.65136368793026 0.0558692340082898 no 3149 0.0493321674114283 4627 1271041
SGTC_458 nppb 133 µM -1.65510980845548 0.0554668762011405 no 3150 0.0489511128143373 4602 4549 A chloride channel blocker.
SGTC_2230 bromochlorosalicylanilide 954.5 nM -1.65570355676082 0.0554033143159356 no 3151 0.0488909333391089 4599 77254
SGTC_927 2425-1185 123 µM -1.65605459818868 0.0553657617257124 no 3152 0.0488553812841 4534 730375
SGTC_2622 2-methoxyxanthone 59.94 µM -1.6564406608995 0.0553244859505316 no 3153 0.0488163062717663 4527 71034 A hepatoprotective.
SGTC_2810 7959871 45.46 µM -1.66437051182728 0.0544820325592924 no 3154 0.0480192046065838 4517 2974535
SGTC_1539 benzyladenosine 56 µM -1.66801654502879 0.0540981049031439 no 3155 0.0476562212168083 4596 92208 A nucleotide analog.
SGTC_1232 0279-0259 161 µM -1.66873618711191 0.0540225801583625 no 3156 0.0475848370824005 4563 1560000
SGTC_2998 9066762 71.4286 µM -1.6690995710425 0.053984475594493 no 3157 0.0475488241550004 4574 4945196
SGTC_3010 9080089 71.4286 µM -1.67508660477592 0.0533597312696469 no 3158 0.0469586203750357 4577 17027233
SGTC_826 1683-5028 118 µM -1.67832579559231 0.0530241196673502 no 3159 0.0466417574562883 4615 722377
SGTC_1216 1165-0504 9.65 µM -1.68271854020309 0.0525716655022668 no 3160 0.0462147954368487 4618 6304004
SGTC_1984 st072354 53.1 µM -1.68278902145294 0.0525644309654132 no 3161 0.0462079705344625 4483 5762938
SGTC_10 0279-0212 42.575 µM -1.68377980807193 0.0524628154322911 no 3162 0.0461121154490942 4597 39851 YBR002C RER2
SGTC_886 0866-0150 153 µM -1.68703196129969 0.0521303687180731 no 3163 0.0457986032200533 4600 271463
SGTC_1494 4358-1428 177 µM -1.69253650242415 0.0515714901309535 no 3164 0.0452718631908473 4600 1564571
SGTC_153 4077-0274 519.67 µM -1.69307382062383 0.051517192157899 no 3165 0.0452207083411346 4583 3121976
SGTC_1488 4013-0813 75.9 µM -1.69589922431418 0.0512324223884026 no 3166 0.0449524832998556 4601 2910057
SGTC_293 4049-0273 38.5 µM -1.69702206564602 0.0511196006109207 no 3167 0.0448462444499034 4481 1380311
SGTC_1860 st056228 74.6 µM -1.69925231042518 0.0508960946505184 no 3168 0.0446358269761947 4580 688679
SGTC_503 tyrphostin 8 294 µM -1.70171907621884 0.0506497923685689 no 3169 0.0444040213213102 4597 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.70184336298281 0.0506374077160373 no 3170 0.0443923676260832 4658 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_871 0574-0004 149 µM -1.70314496505062 0.050507853398502 no 3171 0.0442704714634782 4541 9551173
SGTC_8 0354-0001 70 µM -1.70459717919698 0.0503636197982934 no 3172 0.0441347889106344 4584 4993152
SGTC_2747 doxorubicin 7.63 µM -1.70690612202631 0.0501349720840838 no 3173 0.0439197513758423 4651 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2669 eugenol 100 µM -1.70712423981284 0.05011341538061 no 3174 0.0438994812883109 4630 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1358 1509-0022 2.48 µM -1.71110370977433 0.0497214179112259 no 3175 0.0435309847347822 4614 3258434
SGTC_3334 9142812 21.919 µM -1.71643120327969 0.0492004675986405 no 3176 0.0430415747979886 4581 45283678
SGTC_415 dibenzyl ketone 100 µM -1.72044169952225 0.0488111833259353 no 3177 0.0426760913030054 4574 7593
SGTC_3048 9093155 49.47 µM -1.72200173479017 0.04866042297267 no 3178 0.0425346021193397 4596 25236002
SGTC_3160 9100216 49.47 µM -1.72237437753578 0.0486244662586931 no 3179 0.042500861048929 4596 17191039
SGTC_1606 st000094 49.2 µM -1.72544713579147 0.0483287814835304 no 3180 0.0422234614711225 4617 1242210
SGTC_1220 1838-0075 193 µM -1.73516745325558 0.0474028780906895 no 3181 0.0413555747437015 4533 5529645
SGTC_1118 chelidonine 707.474 nM -1.73691915379442 0.0472375422757031 no 3182 0.0412007210313503 4601 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2314 7727897 200 µM -1.74120461666428 0.0468350033074741 no 3183 0.0408238591560933 4572 900724
SGTC_2766 oltipraz 83.91 µM -1.74285021769942 0.0466811629533493 no 3184 0.0406798908897544 4576 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.7452818713776 0.0464545803150341 no 3185 0.0404679079885222 4620 616764
SGTC_2182 6325192 200 µM -1.7532139328673 0.0457215978823756 no 3186 0.0397826461597425 4632 736248
SGTC_1136 pergolide 1.05886 µM -1.75415216869882 0.0456355160453978 no 3187 0.039702218289691 4549 47811 A dopamine receptor agonist.
SGTC_1807 st050092 58.9 µM -1.75462843332059 0.0455918693087744 no 3188 0.039661442339555 4609 5008496
SGTC_138 0850-0259 40.9225 µM -1.75690627592734 0.0453835828948628 no 3189 0.0394668928717011 4556 6813004
SGTC_1135 dihydrocapsaicin 536.708 nM -1.75783175577482 0.045299175768434 no 3190 0.0393880701761958 4527 107982 A Capsaicinoid.
SGTC_1632 st005650 90 µM -1.75847344977073 0.0452407251141505 no 3191 0.0393334926186916 4622 2759605
SGTC_1073 triclabendazole 3.09 µM -1.76031031591231 0.0450737439472862 no 3192 0.0391776030166823 4645 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2722 naftopidil 47.16 µM -1.76062780394789 0.0450449328873182 no 3193 0.0391507097497721 4556 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1238 0333-0287 48.8 µM -1.76834453158996 0.0443492104655641 no 3194 0.0385016617555815 4624 7226
SGTC_2045 5106652 78.05 µM -1.77267380497022 0.0439627010421501 no 3195 0.0381413870639705 4616 673349
SGTC_1031 k035-0009 16 µM -1.77617361044679 0.0436522346254222 no 3196 0.0378521532274332 4643 5180959
SGTC_1627 st003713 25.6 µM -1.78865209472117 0.042559646302189 no 3197 0.0368354312488016 4624 16195070 YER133W GLC7
SGTC_76 0433-0009 400.328 µM -1.79272031084023 0.0422082599930977 no 3198 0.0365088285863956 4664 2841569
SGTC_2322 7413319 38.22 µM -1.79624539898836 0.0419056873056615 no 3199 0.036227748683877 4554 1840400
SGTC_2594 a-mangostin 100 µM -1.79715626646185 0.041827790016063 no 3200 0.0361554076140224 4610 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_157 1348-1695 65.819 µM -1.80101660676765 0.0414989546738086 no 3201 0.0358501312514546 4540 5380510
SGTC_1756 st041558 35.5 µM -1.80193863701676 0.0414207240849851 no 3202 0.0357775302463314 4687 3955792
SGTC_392 N-ethylmaleimide 8.33 µM -1.80975190624527 0.0407625862593656 no 3203 0.0351671345703557 4608 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3266 9136860 49.47 µM -1.81730279461485 0.0401346373646396 no 3204 0.0345853811514081 4375 4871271 YPR165W RHO1
SGTC_1379 2144-0755 36.5 µM -1.81737819711475 0.0401284065807563 no 3205 0.0345796119212048 4650 5392327
SGTC_3190 9110366 49.47 µM -1.82051850282566 0.0398696087786138 no 3206 0.0343400405676173 4631 17123768
SGTC_720 r052-1644 49.9 µM -1.82166344076226 0.0397755906926323 no 3207 0.0342530342145091 4636 1422863 YOR257W CDC31
SGTC_172 1112-0046 2.638 µM -1.82522555659708 0.0394842350470968 no 3208 0.0339834993473966 4623 2802135 YIL048W NEO1
SGTC_290 2043-6722 48.1 µM -1.82622891803945 0.039402481346936 no 3209 0.0339078935718447 4646 773758 YLR208W SEC13
SGTC_845 0330-0138 4.51 µM -1.8325505641166 0.0388905569178047 no 3210 0.0334347178282665 4603 9039800
SGTC_3091 9116372 49.47 µM -1.84667379141661 0.0377664206357261 no 3211 0.0323972161741279 4665 17169793
SGTC_635 k038-0028 24.7 µM -1.84873909575444 0.0376042780681667 no 3212 0.0322477477413369 4639 4035102
SGTC_1007 4101-0031 70 µM -1.8554398558212 0.0370821253428266 no 3213 0.031766720192793 4637 1146276
SGTC_3024 9090631 49.47 µM -1.8595134781597 0.036767597357495 no 3214 0.0314771953028843 4650 25236383
SGTC_1906 st060206 94.7 µM -1.86189778834968 0.0365845171130236 no 3215 0.0313087494321613 4649 5133468
SGTC_1563 conessine 56.1 µM -1.86779553867248 0.036134858442482 no 3216 0.0308952877783876 4689 441082 An anti-amoebic, histamine inhibitor.
SGTC_1944 st076371 56.9 µM -1.87415489815494 0.0356550867043228 no 3217 0.0304545392478115 4630 24208455
SGTC_837 0091-0265 12.5 µM -1.88025872567209 0.0351995161106593 no 3218 0.0300364127585363 4672 759367
SGTC_966 1300-0360 30.2 µM -1.88102030735801 0.0351430106127605 no 3219 0.0299845782316771 4643 70588
SGTC_976 1348-1067 47.6 µM -1.88596956013546 0.0347776120217701 no 3220 0.0296495283657403 4668 5310671 YGL099W LSG1
SGTC_2450 5739737 12.93 µM -1.88663265208396 0.0347288944000086 no 3221 0.0296048759125583 4663 2262825
SGTC_1431 4049-0260 9.09 µM -1.89147907728712 0.0343745248401616 no 3222 0.0292802106821385 4684 3854841
SGTC_2692 st077426 47.7 µM -1.89271718819763 0.0342844725240865 no 3223 0.0291977446895498 4628 25238571
SGTC_3336 9143619 71.43 µM -1.89414825613934 0.0341806274165561 no 3224 0.0291026670127907 4651 45595730
SGTC_1194 1488-0194 225 µM -1.89440833960998 0.0341617823164099 no 3225 0.0290854151701139 4654 1391452
SGTC_2833 9001315 45.46 µM -1.89912610160604 0.0338214234447123 no 3226 0.0287739489953613 4591 2989378
SGTC_1324 1418-0026 34.4 µM -1.90127190574224 0.0336675418666328 no 3227 0.0286332034678108 4683 1372513
SGTC_1623 st003709 20.3 µM -1.90133151875399 0.0336632750912398 no 3228 0.0286293015770939 4646 16192618
SGTC_485 niflumic acid 177 µM -1.90276872309314 0.0335605424331885 no 3229 0.0285353650382821 4679 4488 A COX2 inhibitor.
SGTC_1355 1499-0035 1.68 µM -1.90389969429498 0.0334798811564445 no 3230 0.0284616244725468 4669 1548538
SGTC_1832 st054113 55 µM -1.90871499105499 0.0331382368760224 no 3231 0.0281494341144249 4685 1251267
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -1.91673305236212 0.0325757331253428 no 3232 0.0276359269733592 4623 6708760
SGTC_2408 sulbentine 18.36 µM -1.92156728582287 0.0322404113430726 no 3233 0.0273301141429833 4534 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_915 methyl methanesulfonate (MMS) 110 mM -1.92313062066422 0.0321325837287492 no 3234 0.0272318238248109 4662 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3073 9114972 49.47 µM -1.92331355501749 0.0321199857098405 no 3235 0.0272203416337213 4666 41905075
SGTC_2479 5617353 43.85 µM -1.93005692436451 0.0316584325403112 no 3236 0.0267998924683716 4655 2731746
SGTC_2911 7942208 15.64 µM -1.93421799977763 0.0313763699613675 no 3237 0.0265431651034195 4650 1243384
SGTC_1859 st055998 20 µM -1.93707985369925 0.031183584927368 no 3238 0.0263677914362513 4612 676301
SGTC_1064 honokiol 6.76 µM -1.93814700081046 0.0311119492197087 no 3239 0.0263026453117364 4662 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2917 7979103 53.79 µM -1.94182571776682 0.0308660462816554 no 3240 0.0260791011904657 4653 2980565
SGTC_1857 st056007 79.3 µM -1.94294269395096 0.0307917014556978 no 3241 0.0260115413394365 4661 619834
SGTC_2260 7964312 200 µM -1.9456236516229 0.0306138643445677 no 3242 0.0258499818999381 4686 231951
SGTC_1147 3809-1045 12.3 µM -1.95271063176148 0.0301478532897183 no 3243 0.0254269465911013 4687 325925
SGTC_13 0199-0087 65 µM -1.95824968777328 0.029787735118489 no 3244 0.0251003606545566 4745 4589825
SGTC_737 1950-0117 57.9 µM -1.96350521646057 0.0294493568427595 no 3245 0.0247937494731864 4667 5393513
SGTC_2852 9023854 51.95 µM -1.96877064766102 0.0291135474544073 no 3246 0.0244897171828648 4675 19798528
SGTC_3299 9121982 43.1275 µM -1.96918733831446 0.0290871088876024 no 3247 0.0244657911655265 4664 17594604 YPL160W CDC60
SGTC_3021 9087658 49.47 µM -1.97268407882335 0.0288660296845029 no 3248 0.0242657835020632 4688 25237042
SGTC_555 4296-0685 37 µM -1.9819088849495 0.028289492056094 no 3249 0.0237447196726114 4664 2908540 YHR072W ERG7
SGTC_1658 st012944 20 µM -1.98427450444266 0.0281431979838561 no 3250 0.0236126233960533 4550 24207260
SGTC_1700 st030840 7.9285 µM -1.9976081297388 0.0273303565044407 no 3251 0.0228795805895682 4716 5499307
SGTC_1389 3405-0187 19 µM -2.00172364918012 0.0270834571254599 no 3252 0.022657230730166 4663 799890
SGTC_854 0422-0053 192 µM -2.01138637696582 0.0265110761278439 no 3253 0.0221423305811356 4702 3596728
SGTC_1108 betulinic acid 729.144 nM -2.01272818043612 0.0264323981362155 no 3254 0.0220716165289898 4664 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1281 0884-0031 11.8 µM -2.01597214095863 0.0262429910871861 no 3255 0.0219014445157134 4699 1548255
SGTC_1327 1436-0082 2.18 µM -2.02070462769813 0.0259687087707007 no 3256 0.0216551752534566 4706 15992205
SGTC_2993 9054257 71.4286 µM -2.02169569842681 0.0259115736871955 no 3257 0.0216038992719245 4627 6470217 YGL055W OLE1
SGTC_2270 7924575 90.91 µM -2.02565430318121 0.0256844086779665 no 3258 0.0214001112916938 4655 1262135
SGTC_325 2810-4341 181 µM -2.02741432639838 0.0255839462115428 no 3259 0.0213100290109824 4694 774970
SGTC_1828 st055811 49 µM -2.02744379723174 0.0255822668153404 no 3260 0.0213085233556489 4691 5877589
SGTC_2076 5212012 200 µM -2.03497920850392 0.0251558798603403 no 3261 0.0209264825329115 4684 604802
SGTC_1720 st037298 9.481 µM -2.04543372705555 0.024574194150317 no 3262 0.0204060583506366 4667 597396
SGTC_1555 citronellol 128 µM -2.0499481714552 0.0243265242243799 no 3263 0.0201847443593707 4696 8842 A terpine precursor.
SGTC_2214 7179297 48.276 µM -2.05435384543343 0.0240868457749667 no 3264 0.019970728373431 4746 769744
SGTC_2649 anisomycin 9.56 µM -2.06487294916323 0.0235225961850272 no 3265 0.0194675116059276 4726 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2997 9067075 71.4286 µM -2.06768613570244 0.0233735939607006 no 3266 0.019334773230255 4670 27209819
SGTC_2811 7967822 32.47 µM -2.07142928249092 0.0231765679841462 no 3267 0.0191593483792611 4690 2232244
SGTC_1853 st056710 91.2 µM -2.0979070510325 0.0218224224088992 no 3268 0.0179566785145562 4716 269167
SGTC_2552 juarezic acid 87.02 µM -2.12394147332393 0.0205567195961541 no 3269 0.0168375189224894 4691 1549512
SGTC_2480 5767542 37.17 µM -2.12420763409432 0.0205441079664439 no 3270 0.0168263925782811 4664 2867358
SGTC_3274 9138298 49.47 µM -2.13758471737265 0.0199186448015282 no 3271 0.0162752315966142 4686 17015756
SGTC_2419 paclitaxel 166.5 µM -2.14716934076511 0.0194805038860027 no 3272 0.015889901290921 4669 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1236 0330-0013 258 µM -2.1489278968914 0.01940101047295 no 3273 0.0158200580115012 4731 4617066
SGTC_950 1165-0508 94.1 µM -2.16456955808308 0.0187059983049791 no 3274 0.0152103321938241 4697 6148369
SGTC_1638 st008370 60.6 µM -2.16509957760183 0.0186828237960967 no 3275 0.0151900301616002 4674 24207134
SGTC_365 0121-0052 13.6 µM -2.17251179381743 0.0183612849261848 no 3276 0.0149085405193245 4682 3101739
SGTC_829 1635-0120 117 µM -2.17933946168889 0.0180692864337399 no 3277 0.0146532298811465 4706 285054
SGTC_870 0573-2213 57.6 µM -2.21623975687536 0.0165587886798622 no 3278 0.0133375432036865 4731 3916321
SGTC_319 1348-1596 45.5 µM -2.22470053494999 0.0162280998698193 no 3279 0.0130506741722628 4757 5380505
SGTC_366 0181-0206 4.31 µM -2.23952604305893 0.0156622808517064 no 3280 0.0125608543731957 4689 274874
SGTC_2541 muurolladie-3-one 83.07 µM -2.2402009807916 0.0156369296129181 no 3281 0.0125389390144033 4691 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_264 promethazine 12.5 mM -2.24782553484052 0.0153529816767241 no 3282 0.0122936584771012 4640 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_477 mead ethanolamide 10 µM -2.24787414254522 0.0153511857632072 no 3283 0.0122921082071625 4761 16061185
SGTC_326 k292-0812 17.5 µM -2.25385878299437 0.01513144466431 no 3284 0.0121025266790642 4746 3579357
SGTC_1348 1493-0373 93.8 µM -2.25445235228316 0.0151097983283928 no 3285 0.0120838624871277 4745 3010129
SGTC_1726 st035556 14.5795 µM -2.25763759473511 0.0149940925992375 no 3286 0.0119841314012417 4724 5919439
SGTC_56 0957-0365 83.25 µM -2.26270270359374 0.0148116682050457 no 3287 0.0118270110286938 4681 6752360
SGTC_1356 1502-0781 85.8 µM -2.28245459420638 0.0141184060190463 no 3288 0.0112312576433644 4749 567702
SGTC_3181 9108277 49.47 µM -2.28474366089815 0.0140399005537998 no 3289 0.0111639314506296 4735 17097298
SGTC_2821 7996764 71.43 µM -2.28815954555933 0.0139234496661796 no 3290 0.0110641158145312 4700 2987135
SGTC_1641 st009299 47.1 µM -2.2921546879584 0.0137883087490014 no 3291 0.0109483592988956 4740 4046054
SGTC_2155 5570423 76 µM -2.30234438867587 0.013448740584305 no 3292 0.0106578792177529 4738 797402
SGTC_774 k060-0086 136 µM -2.30236918616519 0.0134479231038416 no 3293 0.0106571805776268 4732 5911235
SGTC_3025 9087895 49.47 µM -2.31878657104084 0.0129160338023618 no 3294 0.0102033058493407 4738 17173641
SGTC_1089 terbinafine 2.25 µM -2.32389719931203 0.0127542169607324 no 3295 0.0100655022065112 4756 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1055 3448-0672 86 µM -2.32783193218316 0.012630830149465 no 3296 0.00996051488498513 4715 748378
SGTC_2254 7938975 95.19 µM -2.32861248295209 0.0126064765316766 no 3297 0.00993980208140241 4742 2969277
SGTC_2009 4012297 12.05 µM -2.34372369209884 0.0121429452446549 no 3298 0.00954615479859287 4702 45595307
SGTC_31 0508-1974 57.237 µM -2.35812472024488 0.0117150204384648 no 3299 0.00918376038680984 4719 6810525
SGTC_1775 st081588 35.1725 µM -2.36644710364117 0.0114737387962208 no 3300 0.00897987025500703 4725 1426443 YGL099W LSG1
SGTC_2773 thioridazine 9.09 µM -2.37652400349395 0.0111873776948945 no 3301 0.008738312135375 4737 5452 An antipsychotic.
SGTC_2684 capsaicin 100 µM -2.37805854817451 0.0111443193610273 no 3302 0.00870203114187559 4770 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2458 5808907 16.39 µM -2.38051835506276 0.0110755993867473 no 3303 0.00864414986287237 4784 2731747
SGTC_1746 st038117 42 µM -2.38336449230606 0.0109965466375106 no 3304 0.00857759952831241 4741 2898218
SGTC_1265 0819-1001 68.8 µM -2.39357397762373 0.0107169983443395 no 3305 0.00834255810762449 4707 3106768
SGTC_2977 9011197 71.43 µM -2.39987176561966 0.0105476604260762 no 3306 0.00820040811525724 4759 2704722
SGTC_876 0720-0963 56.8 µM -2.4172408995912 0.0100926566185174 no 3307 0.00781933166440084 4759 765861
SGTC_2264 7948757 110.76 µM -2.42466793624807 0.00990338507593296 no 3308 0.0076611973575008 4724 2971411
SGTC_2110 5483698 200 µM -2.46218053795514 0.00899402520181208 no 3309 0.0069047567257501 4747 2848765 YHR062C RPP1
SGTC_1357 1503-1303 39.5 µM -2.47748010975674 0.00864467490510218 no 3310 0.00661568917123292 4747 292895
SGTC_557 1315-0110 16.2 µM -2.490042228938 0.00836678735532507 no 3311 0.00638639590298196 4753 6833801
SGTC_2870 9038528 12.99 µM -2.50683816663658 0.00800751195961274 no 3312 0.00609082353554632 4752 6463316
SGTC_2146 5545642 200 µM -2.53633536242205 0.00740928340664095 no 3313 0.0056009700755977 4750 825326
SGTC_1487 3970-0795 2.82 µM -2.54909687383979 0.00716291680632459 no 3314 0.00540011474041022 4782 3765103
SGTC_1661 st013063 9.66 µM -2.55989978921216 0.0069600388984204 no 3315 0.00523511749316321 4783 721395
SGTC_295 k015-0027 31 µM -2.57266341261203 0.00672689004341099 no 3316 0.00504596505584188 4790 3887424
SGTC_2280 7785178 200 µM -2.57374051311189 0.00670753447233091 no 3317 0.00503028474944849 4762 2954328
SGTC_505 gw-5074 63.9 µM -2.58003595224693 0.00659538648284932 no 3318 0.00493950148081154 4747 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3296 9122258 64.045 µM -2.58809661746113 0.00645421474955287 no 3319 0.00482539535773836 4737 4730474
SGTC_3286 9117135 37.221 µM -2.59083673277625 0.0064068378251324 no 3320 0.00478714512269416 4742 3438150
SGTC_2453 5731132 22.18 µM -2.59225452219135 0.00638244509370725 no 3321 0.00476746002743517 4769 1362040
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -2.61565411919658 0.00599156553019341 no 3322 0.00445283599888407 4765 6708561
SGTC_2427 5545055 42.75 µM -2.61639850532838 0.00597948700307204 no 3323 0.00444313892030198 4748 5372858
SGTC_2457 5731572 11.68 µM -2.62070017535221 0.00591010933678231 no 3324 0.00438746987446129 4784 2865357
SGTC_1257 0669-0121 16 µM -2.68951897445327 0.00489325863935143 no 3325 0.00357775395130932 4762 4307855
SGTC_3104 9120930 49.47 µM -2.69556990826105 0.00481178591202681 no 3326 0.00351341655170944 4768 17014836
SGTC_1826 st055655 41.6 µM -2.73712338767738 0.00428421602345819 no 3327 0.00309895207459215 4772 676168
SGTC_85 0868-0259 160.055 µM -2.75705867854449 0.00404997340415686 no 3328 0.00291619420786166 4773 83173
SGTC_15 0266-0086 27.098 µM -2.81221662746252 0.00346045466810229 no 3329 0.00246006774301814 4792 1712902 YIL048W NEO1
SGTC_914 3820-6779 408 µM -2.82981167124131 0.00328932107768933 no 3330 0.00232877055800363 4743 2893481
SGTC_2162 5663267 200 µM -2.83861065123094 0.00320662796709342 no 3331 0.00226552032674092 4783 6456493
SGTC_2138 5575593 77.673 µM -2.85003765906645 0.00310203006349176 no 3332 0.0021857026468248 4793 762213
SGTC_1834 st055981 52.8 µM -2.90825103725701 0.00261536578345308 no 3333 0.00181728222900981 4765 471719 YDL150W RPC53
SGTC_2925 9010536 32.5 µM -2.9466790087279 0.002333072067244 no 3334 0.00160603221442905 4762 2994177
SGTC_1486 3970-0793 4.53 µM -2.94743925641199 0.00232777679185564 no 3335 0.00160208848367672 4802 2844330
SGTC_2857 9024691 58.44 µM -2.95205855943867 0.00229583570322745 no 3336 0.00157831530220574 4766 16478292
SGTC_1672 st016598 6.51 µM -3.02311894523958 0.00185201664687414 no 3337 0.00125091943444234 4776 4665860 YNL267W PIK1
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -3.08497565268756 0.00153080614530146 no 3338 0.00101784408369204 4778 6708514
SGTC_1620 st003704 16.5 µM -3.17729846181352 0.00114505507140659 no 3339 0.000743269839909171 4786 2834414
SGTC_1660 st012960 28.1 µM -3.18881508275869 0.0011037637461007 no 3340 0.000714286148851025 4801 24207266
SGTC_3279 9140807 49.47 µM -3.19662058127247 0.0010765589045863 no 3341 0.000695238476088304 4801 45595718
SGTC_23 0213-0011 39.996 µM -3.19982330737463 0.00106557525927132 no 3342 0.000687559307830584 4790 627608
SGTC_465 cgp-37157 41 µM -3.21145755352963 0.00102653498522189 no 3343 0.000660317392842585 4807 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3277 9138724 49.47 µM -3.22218685662887 0.000991698953923815 yes 3344 0.00063608070190381 4791 15943418
SGTC_2086 5274770 176.623 µM -3.26109142336079 0.000874287304541636 yes 3345 0.000554921251118539 4801 689278
SGTC_1887 st057648 70.8 µM -3.29963570466671 0.000770693865383735 yes 3346 0.000484052043543452 4802 688672
SGTC_2779 methotrexate 400 µM -3.43339031441574 0.000492643502943188 yes 3347 0.00029804166356701 4793 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_868 0527-0199 213 µM -3.49051098502568 0.000405046813919327 yes 3348 0.000241048896588348 4797 2849450
SGTC_2949 9072542 2.23 µM -3.56749416524607 0.000309731048376641 yes 3349 0.000180205700994659 4788 16457352
SGTC_783 0848-0141 92.7 µM -3.5945505446486 0.000281518320283287 yes 3350 0.000162476029094037 4792 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1477 0139-0234 16 µM -3.68488007738917 0.000203725234792225 yes 3351 0.000114405173929889 4808 620880
SGTC_2157 5649910 96.377 µM -3.68969705110916 0.000200202088319768 yes 3352 0.000112260631269748 4794 2858091
SGTC_2967 9089538 49.85 µM -3.93866649608841 7.90709380057948e-05 yes 3353 4.0967863554748e-05 4796 728216
SGTC_2635 hydroquinidine 100 µM -4.99804120908138 8.29466168268622e-07 yes 3354 2.89578050201615e-07 4807 442912 An experimental heart treatment.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -5.14122940479493 4.15354029192231e-07 yes 3355 1.36473271201992e-07 4810 5024745
SGTC_1673 st016611 27.3 µM -5.29880255831432 1.90004426136349e-07 yes 3356 5.82822984692252e-08 4807 5226799