SGTCid condition conc unit YBR238C|YBR238C.score YBR238C|YBR238C.strain.pval YBR238C|YBR238C.strain.significant YBR238C|YBR238C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_117 lucigenin 22.078 µM 9.32654359875146 7.92333284408245e-16 yes 1 5.46898445613376e-21 9 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_1729 st035615 45.989 µM 6.45094626991201 1.83676866973352e-08 yes 2 5.55769531185399e-11 7 17385451 SGTC_795 0685-0265 78 µM 6.3466831302299 3.03854626286079e-08 yes 3 1.10003310787728e-10 6 302754 SGTC_115 0527-0192 112.043 µM 5.41621666986162 1.92668578533265e-06 yes 4 3.04366643685084e-08 20 4233931 SGTC_1123 mangostin 811.285 nM 5.22825177564204 4.13526932397161e-06 yes 5 8.55601891065236e-08 14 5281650 An antioxidant. SGTC_1255 0566-0045 221 µM 4.92880740441898 1.32608797636725e-05 yes 6 4.13665404409423e-07 11 2788469 SGTC_674 0498-0004 451 µM 4.64396071369655 3.78945375606066e-05 yes 7 1.70896291287191e-06 11 4231473 SGTC_3140 9094243 49.47 µM 4.60705309001716 4.32369316990285e-05 yes 8 2.04207876737972e-06 19 19291112 SGTC_769 0302-0231 76 µM 4.53310781505224 5.61524895084713e-05 yes 9 2.90610645317065e-06 25 571869 YER009W NTF2 SGTC_178 4092-0806 87.505 µM 4.28333718825662 0.000131992117406568 yes 10 9.20554165850309e-06 80 2169044 SGTC_799 1310-0557 151 µM 4.28163435678822 0.000132743666201697 yes 11 9.27628259052184e-06 15 5354492 SGTC_1759 st043059 70 µM 4.27793757920402 0.000134389077672761 yes 12 9.43164483264855e-06 14 669426 SGTC_1533 dihydroergotamine mesylate 29.4 µM 4.20416957014598 0.000171499492674219 yes 13 1.31021219180604e-05 11 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1017 4239-0030 168 µM 4.19305847640568 0.000177857170244585 yes 14 1.37609230696861e-05 21 1149593 SGTC_2148 5546263 113.568 µM 4.13043034837671 0.000218012478811788 yes 15 1.81042393970657e-05 16 792097 SGTC_194 1486-1323 56.904 µM 4.11910909624964 0.000226119058084902 yes 16 1.90170026961087e-05 17 5178754 SGTC_2980 9014342 25.29 µM 4.1185254825605 0.000226544485003317 yes 17 1.90652204992843e-05 23 2996599 SGTC_1397 3532-0190 20.1 µM 4.04178903271792 0.000289465092387015 yes 18 2.65224730052158e-05 5 5322280 SGTC_2706 st078239 82.5 µM 4.02133446184326 0.000308795167431588 yes 19 2.89346844760006e-05 9 15434492 SGTC_146 3448-8650 53.125 µM 3.98027240358753 0.000351277129458383 yes 20 3.4418171276083e-05 136 2891488 YIL048W NEO1 SGTC_1722 st034304 3.6505 µM 3.96817581091467 0.000364791368404384 yes 21 3.62124482366959e-05 27 4036148 YLR033W RSC58 SGTC_889 0919-1524 82.7 µM 3.90063674191796 0.00044954708101692 yes 22 4.79700086890495e-05 13 3905452 SGTC_958 1222-0007 33 µM 3.89176366094051 0.000461948506185708 yes 23 4.97590812136718e-05 27 7312461 SGTC_1862 st057513 3.81 µM 3.86737315906133 0.000497689845399936 yes 24 5.50070088595122e-05 14 5393163 SGTC_1247 0448-0043 5.84 µM 3.85111069372489 0.000522925150237075 yes 25 5.87916664962083e-05 50 3089013 YGL099W LSG1 SGTC_976 1348-1067 47.6 µM 3.82228466284179 0.000570585769473811 yes 26 6.61104637238792e-05 36 5310671 YGL099W LSG1 SGTC_743 1275-0778 158 µM 3.74233540973486 0.000724580531514598 yes 27 9.11589723203253e-05 40 2849257 YMR203W TOM40 SGTC_465 cgp-37157 41 µM 3.65129727906379 0.00094607142604979 yes 28 0.000130459504427869 15 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1021 4476-0760 85.3 µM 3.63143909543198 0.00100199094226087 no 29 0.000140922588195277 38 746768 SGTC_1991 st073000 8.92 µM 3.608100580368 0.00107158036216412 no 30 0.000154223459714256 92 4301969 YIL048W NEO1 SGTC_2965 9082772 38.63 µM 3.59306124733508 0.00111874292556346 no 31 0.00016340786536467 50 16459634 SGTC_2654 protoveratrine a 100 µM 3.56047404901521 0.0012275269335002 no 32 0.000185092948153295 17 5702278 A heart drug and vasodilator. SGTC_22 0964-0034 14.468 µM 3.48863987186612 0.00150229842533396 no 33 0.00024274237317392 63 138402 SGTC_2393 9031399 185.94 µM 3.4611858018448 0.00162136153130227 no 34 0.000268900746346671 50 1526623 YDL150W RPC53 SGTC_834 0312-0008 75.7 µM 3.45750991088302 0.00163793980655849 no 35 0.000272596094107293 57 6385573 YIL048W NEO1 SGTC_2774 tamoxifen 10.92 µM 3.45158333510452 0.00166499411576918 no 36 0.000278653812147877 26 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_578 3460-0051 92 µM 3.43746723971762 0.00173107955013024 no 37 0.0002935908723251 26 2876744 SGTC_1754 st042065 16.137 µM 3.42991081553627 0.00176742825347146 no 38 0.000301889833391842 228 1126236 YIL048W NEO1 SGTC_3056 9094900 49.47 µM 3.42196908138839 0.00180637765464463 no 39 0.000310846914053248 40 25236784 SGTC_2005 4024620 188 µM 3.39668643554292 0.00193562867899205 no 40 0.000341035382393363 40 236743 SGTC_398 bronopol 33.3 µM 3.37080429645744 0.00207659451056275 no 41 0.000374745403638167 37 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1892 st058411 7.36 µM 3.36654096163657 0.00210068829972766 no 42 0.000380586383793714 47 3934738 SGTC_1530 rhein 70.4 µM 3.34496607923034 0.00222654976252925 no 43 0.000411463171241464 39 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2828 7998861 71.43 µM 3.33446264717122 0.00229026359381465 no 44 0.000427321890685844 34 2988188 SGTC_3228 9131799 49.47 µM 3.31548561080007 0.00240957927417999 no 45 0.00045742025355984 21 17015818 SGTC_922 1866-0035 480 µM 3.29592171661327 0.00253844641680679 no 46 0.000490496733025869 98 3156169 SGTC_2927 9011802 47.9 µM 3.29455953483204 0.00254764696964764 no 47 0.000492880304023857 47 43912568 SGTC_3087 9117406 49.47 µM 3.25928575384156 0.00279664072625021 no 48 0.000558465529873247 41 42546093 SGTC_1233 0325-0408 14.2 µM 3.25702926028528 0.00281329244793416 no 49 0.000562924133817405 47 12874 SGTC_605 1315-0399 119 µM 3.24091326663377 0.00293484402847692 no 50 0.000595737147396531 56 24020461 SGTC_2626 ethyl orsellinate 100 µM 3.22455151672693 0.00306307226907356 no 51 0.000630850767338566 61 75653 A natural product. SGTC_2813 7971799 71.43 µM 3.22206928326582 0.00308296048152833 no 52 0.000636341781311937 49 2234054 SGTC_123 0083-0120 66.675 µM 3.19644842545204 0.00329513812536914 no 53 0.000695653485144013 74 16001701 SGTC_122 0236-0016 402.397 µM 3.19522243521068 0.00330561269461679 no 54 0.00069861554271343 79 6808838 SGTC_2496 diffractaic acid 79.83 µM 3.18398626777977 0.00340301540861162 no 55 0.000726309516958866 48 94870 An apoptosis inducer which activates caspases. SGTC_1941 st076221 61.8 µM 3.17321203893184 0.00349882803167296 no 56 0.000753811869642184 124 2828568 SGTC_501 nsc-95397 161 µM 3.134890852956 0.00385954961374269 no 57 0.000859590317967831 35 262093 SGTC_2072 5231554 129 µM 3.13390940258824 0.00386921065885155 no 58 0.000862470522141218 32 789545 SGTC_125 0133-0007 11.75 µM 3.11218689388029 0.00408866135489191 no 59 0.00092853445550538 38 26541 SGTC_198 3454-2873 16.191 µM 3.10359114584912 0.00417853147370578 no 60 0.000955936674336182 44 710957 SGTC_304 1310-0298 97 µM 3.09803428532735 0.00423756586418448 no 61 0.000974044448824694 111 1550234 SGTC_7 0192-1582 4.227 µM 3.08410899265305 0.0043887931487472 no 62 0.00102081392299887 123 252616 SGTC_2858 9025781 8.96 µM 3.06578201788133 0.00459516476218467 no 63 0.00108550764391199 162 4894980 YPL153C RAD53 SGTC_622 1348-1566 26.3 µM 3.06140627384228 0.00464570113678809 no 64 0.00110149975369296 55 7340407 SGTC_2358 9037157 4 µM 3.03848886428463 0.00491856559182494 no 65 0.00118883946070997 72 2388925 SGTC_2860 9025725 38.96 µM 3.03834077110711 0.00492037433919375 no 66 0.0011894239135566 40 40546248 SGTC_116 0155-0182 31.788 µM 3.01601636461367 0.00519990861089983 no 67 0.00128059718376323 161 771486 SGTC_3255 9139072 49.47 µM 3.00548031244326 0.00533667754566533 no 68 0.00132580880604833 52 17646060 SGTC_2756 carbadox 75.1 µM 2.99565561997055 0.00546708482399114 no 69 0.00136927761871783 118 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1719 st032227 49.2 µM 2.98052462993742 0.00567346708314441 no 70 0.00143877548438986 74 3125804 SGTC_2928 9011484 9.79 µM 2.97073684590531 0.00581062640183911 no 71 0.00148543113437215 75 2994751 SGTC_631 k072-0230 41.5 µM 2.95817815226958 0.00599092019956946 no 72 0.00154731607960826 67 5773147 SGTC_141 0443-0274 32.331 µM 2.95326473712402 0.00606279641776008 no 73 0.0015721608963112 110 1627241 SGTC_2826 7992541 19.48 µM 2.94972981495549 0.00611497892073708 no 74 0.00159025966589533 58 2985066 SGTC_1934 st074720 32.6 µM 2.92796945099859 0.00644505826323833 no 75 0.00170591782952987 111 17250992 SGTC_2088 5278280 127.392 µM 2.91386010430606 0.00666741480442675 no 76 0.0017849492193282 82 791502 SGTC_672 1441-0018 53.7 µM 2.91186366547346 0.00669941925231024 no 77 0.00179639705649369 55 251141 SGTC_2052 5265182 7.135 µM 2.90379597333972 0.00683013767611725 no 78 0.00184334161484527 79 1239884 SGTC_539 4859-0462 2.54 µM 2.90060548604298 0.00688245065272039 no 79 0.001862212287755 76 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_3007 9078383 71.4286 µM 2.8970790412149 0.00694068357675299 no 80 0.00188327422690246 67 6496995 SGTC_2310 7668677 200 µM 2.8750371183871 0.00731462168012749 no 81 0.00201990001471099 102 2197143 SGTC_2315 7733312 200 µM 2.87003244245184 0.00740195937779356 no 82 0.00205214843128647 69 726316 SGTC_1417 3966-0327 90.4 µM 2.8670003980346 0.00745531814191112 no 83 0.00207191245706292 68 651118 SGTC_2541 muurolladie-3-one 83.07 µM 2.80974787811057 0.00852845368162735 no 84 0.00247901614448853 90 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_700 3453-2283 142 µM 2.79461855578201 0.00883376067780566 no 85 0.00259804922505762 98 565664 SGTC_3190 9110366 49.47 µM 2.78507309660191 0.00903127784114106 no 86 0.00267578287151343 54 17123768 SGTC_581 0958-0271 211 µM 2.74874912798797 0.00981869943548673 no 87 0.00299115770157423 144 4591145 SGTC_1227 3909-8010 46.6 µM 2.74703675179763 0.00985725626957142 no 88 0.00300681976948777 87 15982272 SGTC_2802 7925815 54.55 µM 2.73008631316201 0.0102461101045574 no 89 0.00316588726834213 114 1262923 SGTC_2257 7960413 200 µM 2.71698619840625 0.0105557352466107 no 90 0.00329396774067416 147 2974689 YIL048W NEO1 SGTC_1626 st003712 1.76 µM 2.69490917746687 0.0110959940660839 no 91 0.00352039097729078 102 24207035 SGTC_948 3448-0295 75.3 µM 2.6919627375021 0.0111698866347049 no 92 0.00355164406036536 114 678569 SGTC_13 0199-0087 65 µM 2.66885723119499 0.0117643186644637 no 93 0.00380548971557938 66 4589825 SGTC_2669 eugenol 100 µM 2.65509395555926 0.0121312974803311 no 94 0.00396431608839283 42 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_395 anisomycin 6.25 µM 2.61113448129872 0.013370648714332 no 95 0.00451211995429514 57 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1846 st056244 14.8 µM 2.60803073590258 0.013462145078405 no 96 0.00455323885786978 123 5393182 SGTC_1221 2958-7315 257 µM 2.59708161924234 0.0137892478709749 no 97 0.00470097901531781 90 4562705 SGTC_2759 disulfiram 3.38 µM 2.59534232706993 0.0138418348881407 no 98 0.00472483744015354 126 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1403 3909-7815 62.9 µM 2.59464066298323 0.0138630984158836 no 99 0.00473449292310325 78 6615483 SGTC_2814 7977482 42.97 µM 2.58824132216768 0.0140583301316677 no 100 0.00482336857977295 161 6456762 SGTC_1305 1181-0477 144 µM 2.58562736262206 0.0141387561032558 no 101 0.00486009769824974 98 6252086 SGTC_974 1326-0144 138 µM 2.58232022257228 0.0142410776013542 no 102 0.00490692389636188 134 5411856 SGTC_199 4063-0024 41.6 µM 2.56920559840194 0.0146531428511845 no 103 0.00509659808345059 52 306215 SGTC_1965 Pectolinarigenin 58.4 µM 2.56308449833573 0.0148489548325338 no 104 0.00518733979081858 77 5320438 An anti-inflammatory. SGTC_294 k038-0071 157 µM 2.53988441126953 0.0156116772229458 no 105 0.0055444555135497 173 24152826 SGTC_1193 1488-0126 41.5 µM 2.53931159122547 0.0156309267532695 no 106 0.00555354259828419 113 1384710 SGTC_870 0573-2213 57.6 µM 2.53538574287039 0.0157634031676688 no 107 0.00561617818398359 88 3916321 SGTC_1878 temozolomide 1 mM 2.52572560470247 0.0160934879670188 no 108 0.00577298109905802 69 5394 DNA alkylating agent. SGTC_2008 4012253 172 µM 2.52158467910612 0.0162367860294192 no 109 0.00584137764195118 132 603940 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 2.52150708640085 0.0162394815486531 no 110 0.00584266608953112 113 688801 SGTC_2011 4012611 177 µM 2.51964007040185 0.0163044561241671 no 111 0.00587374449981749 132 2049887 SGTC_1430 4049-0248 69.1 µM 2.51902045998443 0.0163260685190657 no 112 0.00588409091376644 120 22774488 SGTC_1096 rimcazole 32.2 µM 2.51738134554587 0.0163833601815665 no 113 0.00591153925039966 82 18528119 A dopamine reuptake inhibitor. SGTC_603 3794-0023 45.9 µM 2.49945745342064 0.0170211664535373 no 114 0.00621918169716872 93 3802260 SGTC_628 1636-0253 16 µM 2.49831942802431 0.0170623690625392 no 115 0.00623918485117184 153 4456143 SGTC_1410 3909-8106 77.9 µM 2.49673131141256 0.0171200098530502 no 116 0.0062671945154446 70 1039210 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 2.48630273531813 0.0175026651156065 no 117 0.00645390543658384 28 279621 SGTC_1012 4112-3522 18 µM 2.48046904538164 0.0177198880640533 no 118 0.0065604827911024 115 3112398 SGTC_1990 st072050 59.8 µM 2.4736705953471 0.0179759332012022 no 119 0.00668664694136915 100 17233948 SGTC_2951 9072950 58.06 µM 2.47314284095679 0.0179959409280683 no 120 0.00669653000092141 125 16488155 SGTC_2998 9066762 71.4286 µM 2.46476359004275 0.0183161600265597 no 121 0.00685518391419481 146 4945196 SGTC_3225 9130819 49.47 µM 2.46066919134697 0.0184743878370366 no 122 0.00693390839257058 112 4547121 SGTC_1511 0906-3109 28.5 µM 2.45808481977532 0.0185748588007687 no 123 0.00698400898814112 200 2882180 SGTC_1354 1498-1681 81 µM 2.45743611529923 0.0186001509863386 no 124 0.00699663482877208 121 5754243 SGTC_3126 9127922 49.47 µM 2.45141166207994 0.0188364405897077 no 125 0.00711485547411226 152 45595682 SGTC_902 1120-0002 2.07 µM 2.44951852172674 0.0189112182535219 no 126 0.00715236762569072 164 3280475 SGTC_575 k072-0246 11.9 µM 2.43362382839377 0.0195490652489833 no 127 0.00747426068287527 132 6796779 SGTC_2771 fluoxetine 41.05 µM 2.42281237600047 0.01999328826745 no 128 0.00770043929243026 111 3386 A selective serotonin reuptake inhibitor. SGTC_972 1319-0219 195 µM 2.41123498433669 0.0204784480999401 no 129 0.00794930072697978 129 23903702 SGTC_1679 SEC14.276 6.7 µM 2.40123296603872 0.0209055873841821 no 130 0.00816996504914248 189 1005053 YMR079W SEC14 SGTC_385 1494-0393 12.4 µM 2.39720052613931 0.0210799146512786 no 131 0.00826043982551431 141 3090647 SGTC_1242 0402-0103 60.1 µM 2.39065802940808 0.0213653709058718 no 132 0.00840910480962702 121 432868 SGTC_1061 3448-9325 110 µM 2.38432899297355 0.0216446170471424 no 133 0.00855514910372677 114 723482 SGTC_1389 3405-0187 19 µM 2.37925192943394 0.0218708477882318 no 134 0.00867390759135616 122 799890 SGTC_2866 9034245 58.44 µM 2.37747855121793 0.0219503375225478 no 135 0.00871572835992744 94 6462273 SGTC_293 4049-0273 38.5 µM 2.36777411151299 0.0223896606690485 no 136 0.00894772909484957 93 1380311 SGTC_2464 5717415 7.67 µM 2.34901510113782 0.0232599276129972 no 137 0.00941157169233497 134 5285744 SGTC_14 0354-0009 295 µM 2.34637283644812 0.0233847655836336 no 138 0.009478566891267 137 1713507 SGTC_1173 0443-0020 122 µM 2.34370566692625 0.0235113515508063 no 139 0.0095466161161983 180 5331295 SGTC_1803 st050068 52.4 µM 2.34313033345978 0.0235387327824379 no 140 0.00956135084750965 380 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2440 5628896 157.78 µM 2.33027475282206 0.0241575858519771 no 141 0.00989581713136474 115 5522048 SGTC_2070 5230947 200 µM 2.32896478391795 0.0242214066308524 no 142 0.00993046569701278 122 2835538 SGTC_1818 st052136 56.3 µM 2.32712790887192 0.0243111363619828 no 143 0.00997922925419929 191 674169 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 2.31276177905931 0.0250225821057986 no 144 0.0103678701340121 154 390807 SGTC_3320 9137005 35.139 µM 2.31002082660673 0.025160284669901 no 145 0.010443500562706 130 4908713 SGTC_1956 st077085 54 µM 2.30117104925185 0.0256092308048683 no 146 0.0106909823062395 152 24208685 SGTC_290 2043-6722 48.1 µM 2.29899693734716 0.025720543192023 no 147 0.0107525566116842 149 773758 YLR208W SEC13 SGTC_2518 prenyletin 46.28 µM 2.29313300035381 0.0260227917766898 no 148 0.0109201745001736 78 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1072 oxiconazole 14.9 nM 2.28754462924188 0.0263135958630002 no 149 0.0110820267981733 182 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2105 5350118 200 µM 2.2723480728237 0.0271181503285542 no 150 0.0115327477021788 145 2133313 SGTC_165 k038-0023 64.381 µM 2.26375995825069 0.0275818411607952 no 151 0.0117944412602011 248 46368543 SGTC_1457 k015-0032 57.3 µM 2.26081672140055 0.0277422657745769 no 152 0.0118853043541002 188 4302660 SGTC_2026 5148700 152 µM 2.2603596230213 0.0277672500804014 no 153 0.0118994701553909 150 79838 SGTC_2716 st080858 38.6235 µM 2.25917842962569 0.0278318991575804 no 154 0.0119361440153268 128 5296050 SGTC_2778 tioconazole 65.09 nM 2.25630456669178 0.0279897152851051 no 155 0.0120257817981439 225 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1847 st056231 15 µM 2.2544383139815 0.0280925978139636 no 156 0.0120843036191904 215 5393180 SGTC_55 0767-0285 6.563 µM 2.2467430762282 0.0285201515019289 no 157 0.0123282257897817 198 3116166 SGTC_305 1682-2595 20.8 µM 2.22023231578797 0.0300347599872126 no 158 0.0132015008651372 160 226033 SGTC_1053 3366-3204 134 µM 2.21609642710064 0.0302769599588955 no 159 0.013342449449535 181 3632071 YPR165W RHO1 SGTC_313 3474-0040 5.03 µM 2.20964325258923 0.030658093004453 no 160 0.0135649654976232 251 1043375 YIL048W NEO1 SGTC_2091 4-phenylthiadiazole 200 µM 2.20699575458848 0.0308156029576842 no 161 0.0136571779708941 176 270010 SGTC_409 arachidonic acid 100 µM 2.19412784741653 0.0315907341814628 no 162 0.0141131099050627 156 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_1621 st003705 32.4 µM 2.18585126257704 0.0320977593693484 no 163 0.0144132444566484 192 24207032 SGTC_683 panaxydol 45 µM 2.18324934281572 0.032258534713809 no 164 0.0145087264176556 176 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1368 1852-0141 284 µM 2.18095905883289 0.0324006032211729 no 165 0.0145932224024594 188 2838987 SGTC_2082 5219693 150 µM 2.17911779131437 0.0325151928032038 no 166 0.0146614594551354 197 2834649 SGTC_2488 5268135 45.7 µM 2.17146303109431 0.0329951690786904 no 167 0.0149480943824577 237 1270356 YLR208W SEC13 SGTC_583 1488-1091 88.9 µM 2.15901211713552 0.0337883406556257 no 168 0.0154246134431225 215 4303273 SGTC_1038 k292-0204 154 µM 2.15208242356031 0.0342365417010391 no 169 0.0156954316085477 158 4454212 SGTC_2697 mebhydrolin 72.4 µM 2.14679846056615 0.0345815738593386 no 170 0.0159046649788731 260 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2111 5486399 200 µM 2.13795862158148 0.0351651804351983 no 171 0.0162600508603861 237 689674 SGTC_1637 st007924 17.4 µM 2.13413810168014 0.03541990018332 no 172 0.0164157388789974 187 683336 SGTC_3020 9089140 49.47 µM 2.12041303785883 0.0363474794782044 no 173 0.0169856140725302 176 17217859 SGTC_2274 7947094 46.08 µM 2.11580405064174 0.0366633921596025 no 174 0.0171807382316294 216 2971028 SGTC_694 1315-0438 43.2 µM 2.11503840719188 0.0367160883733993 no 175 0.017213337004805 141 6793154 SGTC_2902 5787006 60.46 µM 2.1143911753455 0.036760683087307 no 176 0.0172409353764916 185 591003 SGTC_1028 k015-0029 4.8 µM 2.10806703854384 0.0371987555344283 no 177 0.017512595540302 222 4588309 SGTC_87 0100-0052 35.5 µM 2.10526493176911 0.037394216356828 no 178 0.0176341264508048 416 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_3318 9139014 38.6185 µM 2.10255620753232 0.0375839599127739 no 179 0.0177522907135326 163 16643984 SGTC_2598 perillyl alcohol 100 µM 2.0939967066338 0.0381887173454037 no 180 0.018130136813737 229 10819 An apoptosis inducer. SGTC_2699 st077704 54.6 µM 2.08857614194423 0.0385757859618211 no 181 0.0183729473414623 234 645852 SGTC_1062 mesoridazine 14.2 µM 2.07827560605825 0.039320128855528 no 182 0.0188419909517085 209 4078 A neuroleptic. SGTC_1995 st072814 61.1 µM 2.06719111995944 0.0401341337356109 no 183 0.0193580743129337 193 5769371 SGTC_3001 9076041 71.4286 µM 2.04977994762692 0.0414403413242093 no 184 0.0201929546271822 173 16004211 SGTC_895 0964-0006 13.7 µM 2.047589971429 0.04160704801094 no 185 0.0203000964097663 192 6738897 SGTC_2795 7780010 54.55 µM 2.04634887674537 0.0417017642940977 no 186 0.0203610290404291 209 953673 SGTC_1289 0976-0073 69.1 µM 2.04624438737147 0.0417097465451818 no 187 0.0203661661053847 188 3391136 SGTC_2187 6125751 200 µM 2.03791988795608 0.0423496668164341 no 188 0.0207789726525081 201 874498 SGTC_792 4534-1957 155 µM 2.03748188903157 0.0423835553630606 no 189 0.020800887524471 206 1717904 SGTC_601 0986-0029 62.9 µM 2.03529388128689 0.0425531729951309 no 190 0.0209106557374912 257 24747981 SGTC_2321 7390090 138.78 µM 2.03338383724761 0.0427016908191143 no 191 0.0210068794890322 199 649046 SGTC_1009 4106-0057 9.87 µM 2.03061865951409 0.0429174427727654 no 192 0.0211468466903154 201 2928005 SGTC_1297 1068-0111 14.1 µM 2.03015641423547 0.0429535950744523 no 193 0.0211703213229546 176 767057 SGTC_1702 st027038 51 µM 2.02914711464537 0.0430326181339989 no 194 0.0212216541448632 209 5521182 SGTC_1400 3771-8998 51.5 µM 2.02013325387748 0.0437435780352713 no 195 0.0216847836750204 142 670767 SGTC_2049 5262831 67.185 µM 2.01679691697315 0.044009119514664 no 196 0.0218583554132834 233 763417 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 2.00155295027788 0.0452389793604033 no 197 0.0226664167682139 243 688667 SGTC_266 formosanin C 406 nM 1.99816732590041 0.045515844614702 no 198 0.0228492612994929 269 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1800 st050079 29.0735 µM 1.9950824577778 0.0457692998053097 no 199 0.023016943639986 429 3645560 SGTC_1760 st045453 10.4495 µM 1.9917729222802 0.0460424738342285 no 200 0.0231979892469544 323 3323419 YIL048W NEO1 SGTC_2565 isoliquiritigenin 100 µM 1.99139284228871 0.0460739298783936 no 201 0.0232188577716967 197 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1187 1391-0724 117 µM 1.99124598767766 0.0460860884296914 no 202 0.0232269251456442 225 6997986 SGTC_813 k007-0158 173 µM 1.98524620382184 0.0465850367120844 no 203 0.0235585430285802 273 6523916 SGTC_3248 9135562 49.47 µM 1.98485126181925 0.046618031981614 no 204 0.0235805111236202 200 17650701 SGTC_1148 3909-7663 27.7 µM 1.9836296201065 0.0467202122755355 no 205 0.0236485723361819 205 4084526 SGTC_75 0159-0059 199.013 µM 1.97996272362402 0.0470279975198314 no 206 0.0238538587227187 214 5377270 SGTC_2753 fluvastatin 17.09 µM 1.97677538594071 0.0472968493090575 no 207 0.0240335125661067 249 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2920 7982904 15.77 µM 1.97471515061186 0.0474712845225689 no 208 0.0241502413071401 221 6456808 SGTC_2319 6033012 152.6 µM 1.97448960988878 0.0474904117781571 no 209 0.024163048858227 182 847246 SGTC_382 3229-0966 23.2 µM 1.9738030102292 0.0475486777078365 no 210 0.0242020732188376 228 5722370 SGTC_2820 7989630 71.43 µM 1.97137098634602 0.0477555238799671 no 211 0.0243407285899313 180 2984098 SGTC_1502 4534-4282 27.7 µM 1.96210994630054 0.0485497888953471 no 212 0.0248748426022733 194 3278949 SGTC_2726 cimetidine 79.27 µM 1.96054344958103 0.0486851766449639 no 213 0.0249661523516686 150 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_59 0330-0160 1.33 µM 1.95863966459256 0.0488501213161545 no 214 0.0250775004865082 417 4293482 SGTC_1841 st054148 70 µM 1.95304069652986 0.0493378071349637 no 215 0.0254073865512344 215 675442 SGTC_1280 0880-0253 10.1 µM 1.95301324656755 0.0493402076440412 no 216 0.0254090127887697 239 6836607 SGTC_1344 1488-0097 29.1 µM 1.94909669918994 0.0496836680298196 no 217 0.0256419388992044 224 747966 SGTC_3291 9121177 71.43 µM 1.94705077612655 0.0498638416510121 no 218 0.0257643237571665 191 17015612 SGTC_2212 7123476 200 µM 1.94452337823289 0.0500871353420107 no 219 0.0259161845227867 141 1085715 SGTC_2255 7941087 197.44 µM 1.94437819367464 0.0500999864624944 no 220 0.0259249307531186 268 935561 SGTC_1870 st057514 26.5 µM 1.94405830067247 0.0501283113097687 no 221 0.0259442105114415 237 5393161 SGTC_955 1216-0110 33 µM 1.9427654042325 0.0502429206023119 no 222 0.0260222548516052 328 3619719 SGTC_1288 0973-0013 65.5 µM 1.93989555905139 0.0504980654424893 no 223 0.026196191955309 218 4315430 SGTC_610 4215-0184 155 µM 1.93911003381309 0.0505680825537767 no 224 0.0262439705904756 243 5605015 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 1.9371129299342 0.0507464409388935 no 225 0.0263657702081479 245 688751 SGTC_1835 st008666 49.2 µM 1.9347351916103 0.0509594461031518 no 226 0.0265113997715267 190 690455 SGTC_3050 9093513 49.47 µM 1.93390357612377 0.051034112563017 no 227 0.0265624921831048 215 25236664 SGTC_2154 5570129 200 µM 1.93379509487932 0.0510438589505434 no 228 0.0265691630654562 245 673366 SGTC_361 000s-0510 1.45 µM 1.93286928390401 0.0511270977828162 no 229 0.0266261513077368 271 660 SGTC_2977 9011197 71.43 µM 1.9315753985852 0.0512436107795679 no 230 0.0267059673819378 180 2704722 SGTC_904 1141-0088 396 µM 1.93049481325798 0.0513410781351082 no 231 0.0267727786301226 232 1378119 SGTC_579 4491-1009 110 µM 1.92422746310748 0.0519092960402708 no 232 0.0271630390861237 321 1271041 SGTC_2041 5107442 45.335 µM 1.9225038104679 0.0520664409009538 no 233 0.0272711972958771 271 793005 SGTC_3216 9129716 49.47 µM 1.91717612484338 0.0525545546284518 no 234 0.0276077800680583 225 8056934 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 1.91650239704962 0.052616538292668 no 235 0.0276505891940397 252 5106787 A p450 inhibitor. SGTC_1693 xanthone 101.9 µM 1.90796399578093 0.0534071170038314 no 236 0.0281979349524514 261 7020 An insecticide. SGTC_2092 5303694 80.6725 µM 1.90206952511566 0.0539583629028739 no 237 0.0285810329632122 280 1963699 SGTC_1559 coumarin 343 70.1 µM 1.89473284454892 0.0546507644655278 no 238 0.0290639020417541 203 108770 A hepatotoxic, DNA x-linker. SGTC_936 3005-4620 401 µM 1.89425294128517 0.05469629915879 no 239 0.0290957220213197 287 777207 SGTC_2688 kanamycin b 96.69 µM 1.89354856295355 0.0547631870506599 no 240 0.0291424782324597 825 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1164 k060-0068 93.7 µM 1.89172814640507 0.0549363536505356 no 241 0.029263605583396 280 5963676 SGTC_1136 pergolide 1.05886 µM 1.88807773299089 0.0552849018530397 no 242 0.0295077578412501 356 47811 A dopamine receptor agonist. SGTC_2879 9041815 71.43 µM 1.88578490069507 0.0555047171765085 no 243 0.0296619732330317 133 4942971 SGTC_163 TUB2.036 7.546 µM 1.88565154046795 0.055517523710953 no 244 0.0296709635563 445 15992207 YJR013W GPI14 SGTC_2324 6149169 200 µM 1.87611464018284 0.0564394122115749 no 245 0.0303197698985429 221 2888231 SGTC_2991 9074669 71.4286 µM 1.87206276833448 0.0568347217482604 no 246 0.0305989600755725 320 17333109 SGTC_2365 9042475 200 µM 1.87165996532017 0.0568741389664006 no 247 0.0306268307945756 283 6464479 SGTC_86 0417-1630 471.922 µM 1.87140576367048 0.0568990255332673 no 248 0.03064443031566 430 3634867 SGTC_2837 9008476 45.46 µM 1.87121523975439 0.0569176836151345 no 249 0.0306576266317175 298 2992805 SGTC_969 1313-0238 134 µM 1.86937145342866 0.0570984953416133 no 250 0.0307855766546027 316 5212874 SGTC_2190 6049624 200 µM 1.86278241907575 0.0577483492933939 no 251 0.0312464422616547 184 2265554 SGTC_1335 1486-0900 202 µM 1.85705628226253 0.0583178089675476 no 252 0.0316515735607543 311 X1335 SGTC_3132 9126706 49.47 µM 1.85281559268621 0.0587423778602767 no 253 0.0319543972645623 253 850858 SGTC_1703 st026983 48.3 µM 1.84350428634473 0.0596831157778957 no 254 0.0326277082349214 262 1104023 SGTC_671 0560-0003 407 µM 1.84183093982353 0.0598534215012762 no 255 0.032749941421439 242 3238678 SGTC_932 2857-0803 154 µM 1.84031595130301 0.0600079383727552 no 256 0.0328609324217819 282 674898 SGTC_2604 4'-hydroxychalcone 11.32 µM 1.83610307329327 0.0604392610231438 no 257 0.0331712069332308 272 5282362 SGTC_639 0833-0042 114 µM 1.83178005069053 0.0608843785277936 no 258 0.0334920982837196 308 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1220 1838-0075 193 µM 1.8292531599754 0.0611457428656332 no 259 0.0336808460267481 280 5529645 SGTC_1888 azatryptophan 97.5 µM 1.82355951648842 0.0617378678408313 no 260 0.0341093458045261 228 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1674 st016616 23.6 µM 1.82231261608957 0.0618681380102176 no 261 0.0342037825014558 294 625830 SGTC_903 1134-0042 114 µM 1.8196100604206 0.062151224423482 no 262 0.0344092042595508 291 701009 SGTC_2881 9058953 51.95 µM 1.81899682414951 0.0622155999380378 no 263 0.0344559573000568 311 17122249 SGTC_1531 st059297 52.4 µM 1.81813908913275 0.0623057293590591 no 264 0.0345214384323515 277 7566702 SGTC_3043 9092303 49.47 µM 1.80873758610437 0.0633003114806637 no 265 0.0352458903875096 268 25236084 SGTC_2691 st077356 60.2 µM 1.80720474421935 0.0634636358490013 no 266 0.0353651807514939 296 2839272 SGTC_3113 9123498 49.47 µM 1.80164046765754 0.0640592671445419 no 267 0.0358009950204828 239 8897275 SGTC_1249 0481-0015 10.2 µM 1.7976581672953 0.0644882166908021 no 268 0.0361155972334846 254 4227577 SGTC_2109 5483026 200 µM 1.79457322125337 0.0648220398630373 no 269 0.0363608614346476 327 759335 SGTC_3089 9117425 49.47 µM 1.78577949391127 0.0657809774783263 no 270 0.037067484105754 296 9401657 SGTC_1466 k213-0079 57.5 µM 1.78551031167572 0.0658105037565772 no 271 0.0370892901288356 284 3657981 SGTC_1070 indatraline 8.81 µM 1.77527596272849 0.0669407344991274 no 272 0.0379261661698694 320 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1564 D-Arginine 115 µM 1.77502746027667 0.0669683634304048 no 273 0.0379466765762333 309 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2661 dactinomycin 12.96 µM 1.77317769727911 0.06717430054595 no 274 0.038099633233187 310 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2476 5806916 10.51 µM 1.77214038740423 0.067290000040169 no 275 0.0381856280912786 251 2870194 SGTC_1694 st024011 44.9 µM 1.77020906109334 0.0675058267208206 no 276 0.0383461602198602 320 2787533 SGTC_477 mead ethanolamide 10 µM 1.7690788147213 0.0676323802254187 no 277 0.0384403613956236 132 16061185 SGTC_2567 aureobasidin a 60 nM 1.76462093119488 0.0681333165980576 no 278 0.0388137476332921 373 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1319 1306-0155 43.7 µM 1.76161198485785 0.0684730503222083 no 279 0.0390674388086605 345 3122360 SGTC_2186 6124449 200 µM 1.76140972285805 0.0684959340865602 no 280 0.0390845402904126 284 3834182 YLR033W RSC58 SGTC_2520 obtusaquinone 4.71 µM 1.75747867906537 0.0689418618284373 no 281 0.0394181264340251 279 5967872 SGTC_2269 7935389 174.42 µM 1.75215114952253 0.0695497706946155 no 282 0.0398739104934521 301 97605 SGTC_3254 9136651 49.47 µM 1.74872996420049 0.0699423231673911 no 283 0.0401688539771354 329 16454030 SGTC_2824 7998404 51.95 µM 1.74756909535646 0.0700759098749149 no 284 0.0402693353333738 285 837851 SGTC_2684 capsaicin 100 µM 1.73669219265458 0.0713371190221369 no 285 0.0412207582867463 293 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_825 1988-2224 89.6 µM 1.73568394585059 0.0714549050311328 no 286 0.0413098668385854 338 1180859 SGTC_2289 7946404 165.07 µM 1.73412207929125 0.0716376609391742 no 287 0.041448212360369 422 1246120 YPR165W RHO1 SGTC_2249 haloperidol 116.36 µM 1.73150804117247 0.071944334778091 no 288 0.0416805959702733 463 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_297 0986-0032 24 µM 1.72555478714326 0.0726465148227064 no 289 0.0422137696488553 270 2847425 SGTC_2913 7966556 36.57 µM 1.72490338474692 0.0727236645203799 no 290 0.0422724427496994 270 2976516 SGTC_1343 1487-0095 224 µM 1.72458963061192 0.0727608467827526 no 291 0.0423007267387507 284 4560101 YGL055W OLE1 SGTC_1949 st076024 69.1 µM 1.72322726154353 0.0729224667722645 no 292 0.0424237178245274 340 2921930 SGTC_1243 0416-0003 5.65 µM 1.72147599030509 0.0731306263319888 no 293 0.0425822426774181 333 2141977 SGTC_701 4424-0219 185 µM 1.71924986451155 0.0733958839909288 no 294 0.0427844423347114 320 2911779 SGTC_3037 9091026 49.47 µM 1.71848998557994 0.0734865968767489 no 295 0.042853639764786 472 25236398 YIL048W NEO1 SGTC_466 geldanamycin 89.2 µM 1.71832824600331 0.0735059160984563 no 296 0.0428683800467302 206 5288382 HSP90 inhibitor. SGTC_3233 9132340 49.47 µM 1.71828424290024 0.0735111727858416 no 297 0.0428723910180958 302 17682950 SGTC_730 1436-0052 41.2 µM 1.71512057121819 0.0738898643217417 no 298 0.0431615617433033 260 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_2960 9079389 5.97 µM 1.71499988923033 0.073904339420359 no 299 0.0431726236188131 328 16457355 SGTC_2285 7945142 200 µM 1.71167861234497 0.0743035581387417 no 300 0.0434779560905718 316 2970608 SGTC_582 0987-0078 156 µM 1.70384927093235 0.0752511624505851 no 301 0.0442046251763059 459 1625765 SGTC_2341 7987486 176.74 µM 1.70316793213375 0.0753340603458579 no 302 0.0442683230008174 356 1258686 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 1.70258008419867 0.0754056392123771 no 303 0.0443233398700176 320 688662 SGTC_352 k048-0007 5.11 µM 1.70168320729868 0.0755149466173862 no 304 0.0444073850135977 384 6811911 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.7007011489518 0.0756347740054462 no 305 0.0444995596364454 350 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2384 9036245 200 µM 1.69760426478463 0.0760135939304394 no 306 0.0447912386817795 329 6462766 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.69271481317327 0.0766146243068642 no 307 0.0452548821331396 308 689007 SGTC_328 k915-0120 63.5 µM 1.68471979568972 0.0776051802240036 no 308 0.0460213226897558 330 6624543 SGTC_1998 st075797 76.8 µM 1.68398363847153 0.077696874284113 no 309 0.0460924154042024 378 24208315 SGTC_2888 9058547 12.99 µM 1.68346624584165 0.0777613687261189 no 310 0.0461424341910577 253 16476514 SGTC_2054 5233173 129 µM 1.68279661009569 0.0778449010197912 no 311 0.0462072357525989 397 6889 SGTC_1860 st056228 74.6 µM 1.67735772786928 0.0785258874965006 no 312 0.0467362751541198 307 688679 SGTC_1093 fluphenazine 7.97 µM 1.67648010492303 0.0786361939345663 no 313 0.0468220949802931 377 6602611 An atypical antipsychotic. SGTC_3355 9151058 44.0485 µM 1.66708286831952 0.0798246822222108 no 314 0.0477489640809448 317 17015728 SGTC_2044 5102272 200 µM 1.66360378032381 0.0802681190475911 no 315 0.0480958179745752 285 592666 SGTC_330 1488-0319 80.1 µM 1.66328481959232 0.0803088660511267 no 316 0.0481277179743006 323 6846614 SGTC_2585 alliin 100 µM 1.65866302486823 0.0809010525111723 no 317 0.0485918570428974 377 87310 A garlic compound which reacts with lipids. SGTC_557 1315-0110 16.2 µM 1.65689346026165 0.0811286558821162 no 318 0.0487705083952803 356 6833801 SGTC_854 0422-0053 192 µM 1.65513097826754 0.0813558282509812 no 319 0.048948966126924 329 3596728 SGTC_234 nsc-17383 10.7 µM 1.65510279865714 0.0813594643111926 no 320 0.0489518236471371 388 408974 SGTC_2034 5197015 53.07 µM 1.654958882289 0.0813780359820687 no 321 0.0489664193955383 328 780676 SGTC_3332 9141069 11.198 µM 1.65095529693536 0.0818959608569958 no 322 0.0493738516331164 304 17332883 SGTC_1610 st001799 48.1 µM 1.64903609008546 0.0821451186549456 no 323 0.0495701206233514 275 621897 SGTC_1999 st074831 12.5 µM 1.64760340239717 0.0823314868385057 no 324 0.049717040896808 368 17112523 SGTC_2750 bromebric acid 70.15 µM 1.64377737499036 0.0828307479897379 no 325 0.0501110982220723 411 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 1.64126077965276 0.0831603801078026 no 326 0.0503716468891802 358 3256 An antibiotic and ribosome inhibitor. SGTC_2445 5742597 35.57 µM 1.63955094331717 0.0833849023480784 no 327 0.0505492850918075 347 1774255 SGTC_1931 st074438 57.1 µM 1.6382610190525 0.0835545863503919 no 328 0.0506836277870095 328 2787313 SGTC_2467 5474540 200 µM 1.63787452146561 0.0836054789350747 no 329 0.0507239359535374 369 5413519 SGTC_90 0870-0863 4.608 µM 1.62591773882495 0.08519143312197 no 330 0.0519835779943552 398 1738164 SGTC_1909 st060837 51.5 µM 1.62466586966175 0.0853587766891766 no 331 0.0521168867479606 390 678937 SGTC_1010 4112-3296 15.2 µM 1.62436627658755 0.0853988612744294 no 332 0.0521488299813706 404 704384 SGTC_778 3456-2434 196 µM 1.62431681542205 0.0854054803743688 no 333 0.0521541051284652 460 5539063 SGTC_2166 5933061 31.504 µM 1.62388937420022 0.0854626983563587 no 334 0.0521997103781295 369 2877375 SGTC_1325 1431-0015 227 µM 1.6234707112463 0.0855187690919776 no 335 0.0522444097401242 318 1103340 SGTC_2053 5265679 138 µM 1.62321202884497 0.0855534277025958 no 336 0.0522720436580631 379 764595 SGTC_3114 9122766 49.47 µM 1.6192118280279 0.0860907196178621 no 337 0.0527008469715654 348 17176985 SGTC_1820 st053765 18.6 µM 1.61142669600896 0.0871436200760728 no 338 0.0535433762502931 342 3690829 SGTC_2381 9035592 200 µM 1.61102916608326 0.0871976409434138 no 339 0.0535866828036132 299 4749657 SGTC_2783 7738165 71.43 µM 1.60697026759148 0.0877506417946785 no 340 0.0540304452645689 294 17201110 SGTC_2003 4023581 200 µM 1.60320161882248 0.0882664362462053 no 341 0.0544450741037218 376 16641307 SGTC_3231 9132313 49.47 µM 1.60293166955289 0.088303469278325 no 342 0.0544748704026755 347 4905967 SGTC_944 3370-0224 231 µM 1.60037375863314 0.088654951552527 no 343 0.0547578464746101 367 4580514 SGTC_1534 6-azauridine 81.6 µM 1.59900525613718 0.0888434246904638 no 344 0.0549097173537928 433 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_139 0099-0334 718.624 µM 1.59669516322927 0.0891622522956088 no 345 0.0551668371703229 452 97690 SGTC_118 0083-0097 135.343 µM 1.59375188948379 0.089569700865622 no 346 0.0554958085432341 621 5207356 SGTC_956 1185-0240 191 µM 1.59293517622423 0.0896830066156193 no 347 0.0555873670117594 364 1416193 SGTC_2020 4017018 200 µM 1.5890258987644 0.0902268317280566 no 348 0.056027272871772 364 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1932 st074806 40.9 µM 1.58503700340689 0.0907842534881128 no 349 0.0564789635832881 406 17251235 SGTC_2428 5615643 7.78 µM 1.58476006171303 0.0908230489193193 no 350 0.0565104298723713 375 2253075 SGTC_1613 st002381 52.1 µM 1.58398360221532 0.0909318849920866 no 351 0.0565987253539395 383 551167 SGTC_920 mycophenolic acid 780.421 nM 1.58395675321294 0.0909356501378731 no 352 0.056601780444911 393 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2791 5663188 71.43 µM 1.57780311273394 0.0918016544720528 no 353 0.0573054242605538 365 54690634 SGTC_432 NS 1619 61.3 µM 1.57691571092495 0.0919270412240518 no 354 0.0574074604997122 360 4552 A K+/calcium channel activator. SGTC_1638 st008370 60.6 µM 1.5749525539879 0.092204878962949 no 355 0.0576336982975111 410 24207134 SGTC_619 1652-1634 108 µM 1.57303369295243 0.0924770479165835 no 356 0.0578555083941855 338 5400454 SGTC_569 4130-2812 160 µM 1.56996529490533 0.0929135003165765 no 357 0.0582115927328781 269 743552 SGTC_1484 3473-2379 286 µM 1.56855357801677 0.0931148152636544 no 358 0.0583759982256169 447 671917 SGTC_907 3448-6986 75.5 µM 1.56854288730174 0.0931163410197006 no 359 0.058377244632974 432 590582 SGTC_2809 7964133 12.99 µM 1.56808279017681 0.0931820226100957 no 360 0.0584309061710486 430 1253665 SGTC_2648 atorvastatin 78.68 µM 1.56518205332644 0.0935969084885518 no 361 0.0587701141662069 341 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_137 0438-0332 85.389 µM 1.56498700769637 0.0936248542929312 no 362 0.0587929778595033 550 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_3122 9126309 49.47 µM 1.5622596146974 0.0940162761482388 no 363 0.0591134208781039 344 17591206 SGTC_3115 9123671 49.47 µM 1.56011039436282 0.0943255712210243 no 364 0.059366897818633 352 3286988 SGTC_592 k241-0073 46.5 µM 1.55326919896954 0.0953150855370987 no 365 0.0601794177470837 410 4230158 SGTC_1068 loratadine 26.9 µM 1.54194045451038 0.0969704529879082 no 366 0.0615440320549317 382 3957 A H1 histamine antagonist. SGTC_2834 9001755 58.44 µM 1.54126631832895 0.0970696196361324 no 367 0.0616259913836069 364 2989575 SGTC_1455 4262-0120 131 µM 1.53774829192767 0.0975883356387527 no 368 0.0620550854792129 404 1529587 SGTC_1518 st038567 90.8 µM 1.53193767393256 0.0984495296311513 no 369 0.062768907809761 346 77966 SGTC_1414 3917-0015 5.4 µM 1.52948697165655 0.098814412867491 no 370 0.0630718832058108 356 6618702 SGTC_2800 7887935 81.82 µM 1.5287267105963 0.0989278084359357 no 371 0.063166103868611 390 2961002 SGTC_1329 1447-1697 50.6 µM 1.52644221520912 0.0992691216243612 no 372 0.0634498855040016 426 2840515 SGTC_2211 7117706 200 µM 1.52600219903231 0.0993349606578858 no 373 0.0635046584210028 370 822771 SGTC_2806 7952793 58.44 µM 1.52527808807885 0.0994433779001673 no 374 0.0635948753600061 413 2972490 SGTC_2949 9072542 2.23 µM 1.52258651198234 0.0998471313911728 no 375 0.0639310931884756 465 16457352 SGTC_2262 9014885 67.46 µM 1.51934388655515 0.100335134365079 no 376 0.064337979197935 294 6457424 SGTC_767 0929-0023 86 µM 1.51767971359621 0.100586261029201 no 377 0.0645475802835001 525 1204563 SGTC_2192 5915882 198.485 µM 1.51087927144771 0.101617225145427 no 378 0.065409606495474 354 2876149 SGTC_3124 9127567 49.47 µM 1.50856208063793 0.101970268734018 no 379 0.0657053653277145 380 17592030 SGTC_1848 st056003 16.4 µM 1.50695095135688 0.102216263401797 no 380 0.0659116149879045 418 146492 SGTC_1338 1486-1223 76 µM 1.50447635637818 0.102594936247045 no 381 0.0662293783632251 439 3444526 SGTC_2777 climbazole 1.536 µM 1.50430392434436 0.102621360470401 no 382 0.0662515645476774 456 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2181 6316240 54.2555 µM 1.50286965821057 0.102841345285765 no 383 0.0664363293260395 379 12779990 SGTC_2199 6590217 200 µM 1.5022830158062 0.102931421969718 no 384 0.0665120165294632 343 703109 SGTC_1300 1094-0077 113 µM 1.50061915932248 0.103187212525005 no 385 0.0667270464744011 376 5532636 SGTC_70 0141-0289 43.283 µM 1.49998887750194 0.103284228430785 no 386 0.0668086418400817 670 352408 SGTC_3206 9114350 49.47 µM 1.49941684460447 0.103372335704275 no 387 0.0668827631927452 392 17087243 SGTC_2348 9022543 33.42 µM 1.49891545500659 0.103449607014766 no 388 0.0669477832208326 448 3162678 YDL140C RPO21 SGTC_205 1486-1330 71.903 µM 1.49784092377389 0.103615348836265 no 389 0.0670872927223707 339 4118834 SGTC_3273 9137859 49.47 µM 1.49339737673868 0.104302792840542 no 390 0.0676665996179777 360 2377234 SGTC_2738 aclarubicin 5.55 µM 1.49191069425193 0.104533528087837 no 391 0.0678612793761233 310 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_3062 9077494 49.47 µM 1.49132833730571 0.104624011439506 no 392 0.0679376563043176 411 16459633 SGTC_1709 st033179 39.1045 µM 1.48802133320431 0.105138911087692 no 393 0.0683726338532586 453 573381 SGTC_3219 9131112 49.47 µM 1.48784628493705 0.105166217070089 no 394 0.0683957180834126 408 17612988 YMR079W SEC14 SGTC_1850 st056238 17 µM 1.48746875530253 0.105225125824734 no 395 0.0684455247126839 475 5393177 SGTC_925 2064-1272 59.6 µM 1.48688226572191 0.105316687503524 no 396 0.0685229544482456 410 6815817 SGTC_2276 7947513 42.08 µM 1.48658989803175 0.105362352934491 no 397 0.0685615787479933 391 2105100 SGTC_278 4092-0821 23.9 µM 1.48405366810079 0.105759092388958 no 398 0.0688973416857896 408 877900 SGTC_2233 sulbentine 40.3845 µM 1.48150226452713 0.106159293964302 no 399 0.0692363909608522 489 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.48033122153262 0.106343344290463 no 400 0.0693924375192615 430 4213774 SGTC_1412 3909-8563 178 µM 1.47851637389178 0.106629035122154 no 401 0.0696348088663296 473 23767530 SGTC_2735 sertaconazole 140 nM 1.47681139929893 0.106897934193707 no 402 0.0698631000230232 335 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2477 5967686 25.23 µM 1.47320542481759 0.10746825913686 no 403 0.0703478263817728 443 776118 SGTC_3283 9109332 35.8195 µM 1.46958889485495 0.108042452951484 no 404 0.0708365648770464 339 17027281 SGTC_1765 st044815 90.4 µM 1.46937409799857 0.108076625449881 no 405 0.0708656744259772 439 645695 SGTC_1294 1000-1494 117 µM 1.46539923782961 0.108710399467304 no 406 0.0714060126359333 429 712797 YDL207W GLE1 SGTC_66 0109-0187 42.4 µM 1.46177201502899 0.109291072629663 no 407 0.0719018476387055 425 759417 SGTC_3024 9090631 49.47 µM 1.45938991071355 0.109673628043666 no 408 0.0722289106679702 384 25236383 SGTC_46 0329-0187a 2.197 µM 1.45725047092468 0.110018031222269 no 409 0.0725236266397579 553 46494817 SGTC_2213 7173844 200 µM 1.45234390819118 0.110810809716659 no 410 0.0732030021960284 436 892728 SGTC_816 0325-0417 81.3 µM 1.4517218129603 0.110911616466627 no 411 0.0732894858094603 404 68101 SGTC_1049 3226-0134 66 µM 1.45064934832495 0.111085557057916 no 412 0.0734387632215937 488 5702385 SGTC_2831 7999036 19.48 µM 1.44822224087173 0.111479925188392 no 413 0.0737774531944232 482 2988270 SGTC_1966 st070145 16.1 µM 1.44632163058948 0.111789444263193 no 414 0.0740435057637576 445 3748532 SGTC_2218 6965428 192.983 µM 1.43974449906397 0.112865288983489 no 415 0.0749698493371931 447 675684 SGTC_505 gw-5074 63.9 µM 1.43926759321619 0.112943584585858 no 416 0.0750373604174144 464 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_3004 9076122 71.4286 µM 1.43895574737136 0.112994802564955 no 417 0.0750815305686677 463 44782551 SGTC_2552 juarezic acid 87.02 µM 1.43333384906008 0.11392099517916 no 418 0.0758812265154963 531 1549512 SGTC_1768 st044301 37.178 µM 1.431148573527 0.114282469497814 no 419 0.0761938193307828 471 3931349 SGTC_1102 cgs 12066b 26.1 µM 1.4308525228132 0.114331503064711 no 420 0.0762362431914809 420 6438352 A 5-HT1B full agonist. SGTC_442 cape 100 µM 1.43027070053982 0.11442791135145 no 421 0.0763196702957699 420 5281787 SGTC_2142 5622915 118.518 µM 1.43001218577712 0.114470765961757 no 422 0.0763567608375072 407 5322196 SGTC_3171 9103192 49.47 µM 1.4247512598374 0.115345365306435 no 423 0.0771145579561199 412 13018434 SGTC_731 3966-0296 387 µM 1.42368090125542 0.115523886301154 no 424 0.0772694324060902 457 660956 SGTC_517 1365-0151 113 µM 1.42125528295236 0.115929172163219 no 425 0.0776212791599207 452 768657 SGTC_3348 9149464 3.537 µM 1.42003248049208 0.116133867129553 no 426 0.0777991126410059 462 1951442 SGTC_2128 5255449 168.493 µM 1.4165751320734 0.116714008714105 no 427 0.0783035917090467 493 736008 SGTC_492 tmb-8 126 µM 1.41573200287623 0.116855796539416 no 428 0.0784269923417001 297 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2622 2-methoxyxanthone 59.94 µM 1.41396914071535 0.117152648952044 no 429 0.0786854816987601 477 71034 A hepatoprotective. SGTC_2237 6667747 47.222 µM 1.4138787574833 0.117167883177042 no 430 0.0786987520161273 436 729940 YDL015C TSC13 SGTC_1195 1502-0147 41.1 µM 1.41365137629943 0.117206214812015 no 431 0.0787321442538694 500 817940 SGTC_1663 st014140 55.4 µM 1.41148832671859 0.117571303242299 no 432 0.0790503376036173 530 4207120 SGTC_1394 3474-0001 65.7 µM 1.41079783958382 0.117688015845081 no 433 0.0791521158535945 418 5017666 YIL048W NEO1 SGTC_2150 5556613 200 µM 1.40985252909209 0.117847934024932 no 434 0.0792916161013155 510 743190 SGTC_1831 st055328 12 µM 1.40717484746666 0.118301751852682 no 435 0.079687774049066 466 1103068 SGTC_952 1185-0122 232 µM 1.40568072466631 0.118555514602174 no 436 0.0799094765854236 489 678600 SGTC_3080 9117754 49.47 µM 1.40469656855711 0.118722874282374 no 437 0.0800557632966988 508 9550191 SGTC_1026 k007-1105 30.6 µM 1.40448288788455 0.118759233577504 no 438 0.080087551906162 574 7066794 SGTC_1137 ixabepilone 100 µM 1.4044005922971 0.118773238858373 no 439 0.0800997973098477 540 154225 A novel microtubule stabilizer. SGTC_2168 5727979 200 µM 1.40348843917902 0.118928549626599 no 440 0.0802356185034046 437 695210 SGTC_857 0438-0306 1.35 µM 1.40173801941382 0.119226992208727 no 441 0.0804967464642914 476 4686136 SGTC_2923 7992654 58.14 µM 1.40062168355015 0.119417600771173 no 442 0.0806636166333852 472 2985126 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 1.39747914446691 0.119955327265951 no 443 0.0811347669598829 490 5377381 SGTC_320 4092-0846 5.34 µM 1.39453450505341 0.120460737615833 no 444 0.0815781286665763 480 1359356 SGTC_2095 5432005 200 µM 1.39334481159738 0.120665358304934 no 445 0.0817577729315693 432 783734 SGTC_2406 ethylparaben 405.7 µM 1.39216768002831 0.120868059134041 no 446 0.0819358136759922 426 8434 A possible steroid mimic. SGTC_217 ketoconazole 989 nM 1.39159799905408 0.120966243605389 no 447 0.0820220825680073 485 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2662 daunorubicin 22.37 µM 1.39093276030972 0.121080968464064 no 448 0.082122908722988 427 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_491 tetrandrine 80.3 µM 1.38959219365387 0.121312390613367 no 449 0.0823263737922341 429 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_3011 9081274 71.4286 µM 1.38828356118409 0.1215385997973 no 450 0.0825253579623016 525 6625322 SGTC_541 4513-1321 94 µM 1.38823593291733 0.121546838370294 no 451 0.0825326069028632 493 747515 SGTC_2677 mitomycin C 100 µM 1.38386177691113 0.122305138809031 no 452 0.0832003912944475 419 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2801 7907800 81.82 µM 1.37706464039932 0.123490063897145 no 453 0.0842461318471672 520 6620925 SGTC_1490 4089-0339 670 nM 1.37488345237737 0.123872002655497 no 454 0.08458379010998 446 742542 SGTC_2420 aureobasidin a 50 nM 1.37448275396085 0.123942257091693 no 455 0.0846459303472043 537 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_800 3448-7362 155 µM 1.37421971647571 0.123988390601173 no 456 0.0846867407639631 778 15991913 SGTC_2466 5983409 37.09 µM 1.3724473119067 0.124299561653377 no 457 0.0849621151372764 494 2879657 SGTC_1513 0337-0559 19 µM 1.37173500121635 0.124424771750822 no 458 0.0850729740785217 434 775073 SGTC_2892 9047358 58.44 µM 1.3657790268326 0.125475166150908 no 459 0.0860041655972461 445 6466771 SGTC_2447 5741742 33.78 µM 1.36354957706049 0.125869938809347 no 460 0.0863546854730694 514 1776504 SGTC_3083 9117465 49.47 µM 1.36084326070187 0.126350313990871 no 461 0.0867816136939195 513 16420915 SGTC_246 cycloheximide 667 µM 1.35339967181664 0.127678145782541 no 462 0.0879639911237992 434 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2752 diclazuril 33.15 µM 1.35088724172551 0.128128509871707 no 463 0.0883657778630009 687 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_548 1436-0017 110 µM 1.35078001181993 0.128147755821747 no 464 0.0883829564025349 604 9677137 SGTC_3036 9090181 49.47 µM 1.34703566988653 0.12882106115415 no 465 0.088984372433207 485 25236586 SGTC_2540 epiandrosterone 100 µM 1.34623746621902 0.128964910414775 no 466 0.0891129728756814 666 441302 A steroid. SGTC_3041 9091929 49.47 µM 1.34616701358355 0.128977612471624 no 467 0.0891243303025362 533 25236887 SGTC_3166 9102297 49.47 µM 1.34459952797187 0.129260442218548 no 468 0.0893772979412675 542 25237072 SGTC_1668 st014914 51.6 µM 1.3442687970405 0.129320172634555 no 469 0.0894307409062664 474 2839556 SGTC_2184 6075246 200 µM 1.34359345309078 0.12944219999316 no 470 0.0895399438656903 515 2267320 SGTC_806 3966-4455 5.86 µM 1.34136323754536 0.129845742538153 no 471 0.0899012736589946 457 714982 SGTC_1074 carmofur 3.8 µM 1.34013036891478 0.130069195326272 no 472 0.0901014821893346 567 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2129 girgensonine 121.053 µM 1.33916022374083 0.130245217491718 no 473 0.0902592591606931 589 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1434 4073-0095 163 µM 1.33730740613726 0.130581848654095 no 474 0.0905611572466174 537 24133745 SGTC_3244 9134489 49.47 µM 1.33392209938048 0.131198464470043 no 475 0.0911146940603993 516 16584271 SGTC_2205 7238770 200 µM 1.32966212279651 0.131977250364864 no 476 0.0918148099519858 481 279867 SGTC_2337 9009472 200 µM 1.32948836509045 0.132009083343383 no 477 0.0918434509199163 579 5742383 SGTC_100 0086-0128 49.5915 µM 1.32774006566968 0.132329672186617 no 478 0.0921319963468189 593 93297 SGTC_1492 4158-0558 28.5 µM 1.32556481965593 0.132729299649759 no 479 0.0924919428116962 496 3967268 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 1.32519051221841 0.132798149642576 no 480 0.0925539857052727 511 6708760 SGTC_1963 st076565 50.3 µM 1.32045824163704 0.133670723297227 no 481 0.0933410346240586 531 4914280 SGTC_1179 1021-1431 9.29 µM 1.31855775403064 0.134022257290244 no 482 0.0936585025102395 595 2840958 SGTC_2113 5491891 107.031 µM 1.31834267140294 0.134062081189834 no 483 0.0936944812519391 549 789979 SGTC_655 k060-0012 42 µM 1.31529855257383 0.134626590805729 no 484 0.0942047922007649 540 5994525 SGTC_2939 9044578 71.43 µM 1.31322449092149 0.135012143568957 no 485 0.0945536568554382 523 2653634 SGTC_2666 tannic acid 100 µM 1.31289501187319 0.135073460930391 no 486 0.0946091639742982 585 16134267 A thiamine antagonist. SGTC_3125 9127534 49.47 µM 1.31120376707383 0.135388508902297 no 487 0.094894465001039 429 1639235 SGTC_1156 4092-0367 4.88 µM 1.30856824361136 0.135880461946363 no 488 0.0953403219236336 551 1357585 SGTC_387 norethindrone acetate 66.7 µM 1.30631495416368 0.13630203578044 no 489 0.0957227368653409 492 541197 SGTC_183 3914-0051 30.55 µM 1.3060274038971 0.136355898632884 no 490 0.0957716192734799 536 1596232 SGTC_2667 digitoxin 100 µM 1.30507893588168 0.13653366537615 no 491 0.0959329852644749 440 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2727 riluzole 51.77 µM 1.30312383596334 0.136900600156862 no 492 0.0962662435915598 485 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_538 2922-0838 53.3 µM 1.30292718518842 0.136937545007865 no 493 0.0962998109180092 625 777039 SGTC_528 3492-0019 172 µM 1.30287489481805 0.136947369965005 no 494 0.0963087380764273 776 2869262 SGTC_3321 9137793 26.8275 µM 1.29895870248787 0.137684561592493 no 495 0.0969790510761865 573 4904192 SGTC_2576 guaiol 23.12 µM 1.29847402113244 0.137775986926262 no 496 0.0970622488886701 584 227829 SGTC_2737 bleomycin 30.5 nM 1.29271961003565 0.138864605733333 no 497 0.0980540264362093 622 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2610 ononetin 44.17 µM 1.29205358329853 0.13899098175419 no 498 0.09816929442298 576 259632 SGTC_21 0849-0113 22.993 µM 1.29022906044206 0.139337578918977 no 499 0.0984855695171726 568 1560156 SGTC_2022 5136654 200 µM 1.28981146200072 0.139416991017501 no 500 0.0985580636504724 539 1713771 SGTC_1285 0929-0069 65.5 µM 1.28842910157702 0.139680085513593 no 501 0.0987983169395487 552 1206237 SGTC_2461 5755302 26.15 µM 1.28299277203759 0.140718014934584 no 502 0.099747304185977 596 2788904 SGTC_232 clozapine 119 µM 1.28185027573629 0.140936809506791 no 503 0.0999475868932437 554 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_887 0885-0007 9.62 µM 1.28178528000845 0.140949263493728 no 504 0.0999589896437778 593 5719458 SGTC_2029 5175081 200 µM 1.27898728767347 0.141486101323281 no 505 0.100450766256005 603 1380876 SGTC_777 1315-0167 517 µM 1.27718112288937 0.141833376730457 no 506 0.100769154938181 535 4221767 SGTC_452 diindolylmethane 8 µM 1.27433430960431 0.142381911003545 no 507 0.101272481055962 493 3071 Inhibits expression of several cancer promoting factors. SGTC_1109 tnp00067 928.257 nM 1.27359829096061 0.14252396290958 no 508 0.101402909122856 576 676295 SGTC_1501 4491-0275 38.4 µM 1.27358991426486 0.142525580166807 no 509 0.101404394240563 552 5104718 SGTC_636 0kpi-0074 126 µM 1.27255439099417 0.142725600363479 no 510 0.101588105869672 515 616434 SGTC_3169 9102970 49.47 µM 1.27120394945658 0.142986734715187 no 511 0.101828050954692 548 17027839 SGTC_1438 4092-1045 4 µM 1.27052731474613 0.143117696634119 no 512 0.101948429739016 564 1351342 SGTC_2421 5690543 90.72 µM 1.269050427593 0.14340382793239 no 513 0.102211539558772 565 3397993 SGTC_1104 tacrolimus 29.8 µM 1.26733456440421 0.143736743053998 no 514 0.102517843226488 610 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_270 tamoxifen 5.46 µM 1.26706570130438 0.143788955619023 no 515 0.102565899164504 608 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2906 7926292 26.41 µM 1.26533799085029 0.144124778119125 no 516 0.10287509670379 568 2966319 SGTC_3074 9116018 49.47 µM 1.26529859195019 0.144132442414911 no 517 0.102882155568109 518 17027303 SGTC_54 0159-0055 9 µM 1.2644411489939 0.144299309468093 no 518 0.103035865650171 563 3319099 SGTC_2452 5863136 48.41 µM 1.26077461639067 0.145014322249801 no 519 0.103695030837416 554 2184096 SGTC_346 4513-0042 7.16 µM 1.25953509296612 0.145256580966405 no 520 0.103918561506219 593 2827372 SGTC_911 3456-4043 236 µM 1.25859276940682 0.145440935535203 no 521 0.104088730018339 606 914281 SGTC_2385 9074692 200 µM 1.25703168197567 0.145746690173932 no 522 0.104371081774812 574 17046906 SGTC_406 estrone 100 µM 1.25514913885355 0.146115979441817 no 523 0.104712312498927 588 5870 A steroid. SGTC_1284 0929-0043 16 µM 1.25463793623922 0.146216367974888 no 524 0.104805112680362 595 1239883 SGTC_2887 9044784 58.44 µM 1.25414945494708 0.146312337828039 no 525 0.104893843818251 598 6465546 SGTC_1526 st051518 75 µM 1.25175233827039 0.146783902171249 no 526 0.105330061128842 537 673993 SGTC_1622 st003707 19.4 µM 1.25022124507462 0.147085634138955 no 527 0.105609369043993 621 10140899 SGTC_490 phenamil 164 µM 1.24941989109284 0.147243722347657 no 528 0.105755768447909 452 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2993 9054257 71.4286 µM 1.24909836940034 0.147307182985314 no 529 0.105814548485242 599 6470217 YGL055W OLE1 SGTC_407 eburnamonine 100 µM 1.2485158966328 0.147422195758403 no 530 0.105921095280455 517 3195 SGTC_3274 9138298 49.47 µM 1.24837072438863 0.147450870261274 no 531 0.105947662471782 606 17015756 SGTC_2061 5245884 80.95 µM 1.24704512816924 0.14771287561775 no 532 0.106190475468689 605 573863 SGTC_235 0330-0087 5 mM 1.24614621092514 0.147890724762284 no 533 0.106355361098472 603 46494818 YHR062C RPP1 SGTC_2782 7736369 71.43 µM 1.24055387927098 0.149000376615411 no 534 0.107385299321407 622 2950836 YOL077C BRX1 SGTC_3209 9113616 49.47 µM 1.23898482288111 0.149312711446411 no 535 0.107675559355948 635 16649353 SGTC_1225 1216-0074 20.6 µM 1.23822843005685 0.149463434305054 no 536 0.107815686354231 587 4241466 SGTC_532 1548-0774 215 µM 1.23330404828732 0.150447174896636 no 537 0.10873117404362 624 5932993 SGTC_1816 st051957 91.6 µM 1.23314777936654 0.150478463092021 no 538 0.108760317102418 587 674121 SGTC_2616 abietic acid 100 µM 1.23269457008863 0.150569229260603 no 539 0.108844869223407 623 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2147 5545932 89.7195 µM 1.23259785554254 0.150588603418289 no 540 0.108862918704572 574 797404 SGTC_1775 st081588 35.1725 µM 1.23183948807349 0.150740579492644 no 541 0.109004524641449 638 1426443 YGL099W LSG1 SGTC_1411 3909-8223 150 µM 1.23031487955097 0.151046418424112 no 542 0.109289607237794 610 X1411 SGTC_326 k292-0812 17.5 µM 1.22930841947671 0.151248542049853 no 543 0.109478095873715 570 3579357 SGTC_892 0929-0076 29 µM 1.22696528713313 0.151719801284173 no 544 0.109917819074328 643 5751038 SGTC_551 k048-0028 34.9 µM 1.22505582312393 0.152104560452999 no 545 0.110277094199653 649 6836383 SGTC_3051 9093778 49.47 µM 1.22466886998892 0.152182610842231 no 546 0.110350003862052 515 17217378 SGTC_576 1073-0113 22.7 µM 1.22047621766234 0.153029994708384 no 547 0.11114219986749 779 5439563 SGTC_1667 st014849 34.6 µM 1.22047361398651 0.15303052191153 no 548 0.111142693090519 635 5348460 SGTC_1445 4239-0156 97.7 µM 1.21886465757229 0.153356540382584 no 549 0.111447782895824 703 4008346 SGTC_277 nystatin 15.5 µM 1.21777405386625 0.153577787912587 no 550 0.11165492336231 626 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_312 4092-0653 6.84 µM 1.21547279077648 0.154045331543238 no 551 0.11209291013804 707 1148278 SGTC_2370 9071495 200 µM 1.21093109871148 0.154970819650235 no 552 0.112960906320109 581 21791103 SGTC_1176 0848-0131 83.3 µM 1.20568554135035 0.156044299165134 no 553 0.113969381026323 673 6769040 SGTC_253 dyclonine 31.25 µM 1.20058146378131 0.157093518490095 no 554 0.114956797453697 666 3180 An oral anasthetic. SGTC_1665 st014639 11.4 µM 1.2003365501982 0.157143980523489 no 555 0.115004330062684 671 981133 YIL048W NEO1 SGTC_227 fluconazole 33.516 µM 1.19725420401723 0.157779978824361 no 556 0.115603744232618 656 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_833 3852-0053 558 µM 1.1964134582495 0.157953747810808 no 557 0.115767625991694 702 3123681 SGTC_2434 5670830 169.91 µM 1.19624489498822 0.15798860231395 no 558 0.115800502909828 624 1549830 SGTC_365 0121-0052 13.6 µM 1.19327439447942 0.158603653139765 no 559 0.116380963586668 689 3101739 SGTC_2517 totarol 10 µM 1.19188218260694 0.158892454346972 no 560 0.116653722703648 564 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2534 helenine 20.12 µM 1.19184539202364 0.158900090877317 no 561 0.116660936776975 567 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3182 9108849 49.47 µM 1.19126750007094 0.159020074041641 no 562 0.116774294103224 645 17133045 SGTC_1623 st003709 20.3 µM 1.19078323256309 0.159120664400362 no 563 0.116869346493433 698 16192618 SGTC_2367 9070478 135.38 µM 1.18891367210624 0.159509393978802 no 564 0.117236819729873 652 572802 SGTC_3263 9137018 49.47 µM 1.18769724304375 0.159762654318046 no 565 0.117476355176779 594 43844957 SGTC_3354 9151612 71.43 µM 1.18768386527551 0.159765441029042 no 566 0.117478991410515 664 27261949 SGTC_1757 st041620 31.8375 µM 1.18713509176667 0.159879782959564 no 567 0.117587169261523 642 5289815 SGTC_712 r015-0009 80.6 µM 1.18594568692442 0.160127789915299 no 568 0.117821874581913 574 6813872 YLR060W FRS1 SGTC_3117 9124945 49.47 µM 1.18239437216238 0.160869782758679 no 569 0.118524627609624 537 17592065 SGTC_3335 9143315 29.6265 µM 1.18086425526732 0.161190168036314 no 570 0.118828326585961 623 4899691 SGTC_1377 2944-0135 198 µM 1.17788791752152 0.161814563513948 no 571 0.119420646280614 644 1894137 SGTC_1495 4469-0029 237 µM 1.17149894557863 0.163160198885772 no 572 0.120699140704138 764 793680 SGTC_1899 st063254 59.6 µM 1.16821936773182 0.163853754959534 no 573 0.121359145034807 573 3093813 SGTC_2915 7971052 15.16 µM 1.16820279345561 0.163857264893753 no 574 0.121362486985812 472 5741558 SGTC_1969 st069479 40.1 µM 1.16800784439049 0.163898552916506 no 575 0.121401800359928 594 3895485 SGTC_53 0973-0023 39.979 µM 1.16377542521872 0.164796595840521 no 576 0.122257516834264 628 674768 SGTC_84 0443-0269 128.823 µM 1.16249576236972 0.165068743538162 no 577 0.122517072504668 682 6150058 SGTC_347 4534-1311 26.2 µM 1.16065964372274 0.165459741428418 no 578 0.122890169835951 659 2862016 SGTC_2504 purpurogallin 52.29 µM 1.15761849846692 0.166108664216363 no 579 0.123509878430328 615 5281571 An antioxidant. SGTC_102 gallobenzophenone 83.616 µM 1.15607813344029 0.166437975404489 no 580 0.123824599635749 664 70837 SGTC_717 1532-0246 73.2 µM 1.15583958204931 0.166489012439657 no 581 0.12387338965606 664 9561992 SGTC_148 3253-0744 288.01 µM 1.15520874699956 0.166624025540703 no 582 0.12400247681701 628 6893655 SGTC_2163 5671233 125 µM 1.15469867966962 0.166733243243732 no 583 0.124106920203334 705 701023 SGTC_329 k048-0121 21.3 µM 1.1528046816502 0.167139197959027 no 584 0.124495281185694 633 6832902 SGTC_1615 st002656 86.5 µM 1.15222357687716 0.167263878120649 no 585 0.124614605860212 666 1584458 SGTC_2312 7706453 155.7 µM 1.14808461285052 0.168153655819952 no 586 0.125466817821442 652 976098 SGTC_880 0833-0487 87.2 µM 1.14787443238919 0.168198920667117 no 587 0.125510202201791 644 76075 SGTC_2543 pimpinellin 60.67 µM 1.14777433711192 0.168220480123712 no 588 0.125530867038847 639 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_1661 st013063 9.66 µM 1.14699400536104 0.168388616220323 no 589 0.125692049239715 721 721395 SGTC_322 k048-0136 19.3 µM 1.14527825699399 0.16875868406363 no 590 0.126046954939477 638 6823282 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.13793217433191 0.170349056253188 no 591 0.127574402550807 664 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3325 9138760 55.175 µM 1.13734586904686 0.170476399348168 no 592 0.127696863331037 659 43844959 SGTC_1437 4092-1038 11.6 µM 1.13449134991202 0.171097259767504 no 593 0.128294250065721 718 3977136 SGTC_2525 harmine 47.85 µM 1.13213790179705 0.171610223047398 no 594 0.128788231199902 627 5280953 A monoamine oxidase inhibitor SGTC_2301 7769476 200 µM 1.13024312834115 0.172023925709718 no 595 0.129186895647643 627 977820 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.12975186382198 0.172131291687908 no 596 0.129290398277054 710 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1105 epirubicin 18.1 µM 1.12961261565066 0.17216173218672 no 597 0.12931974638949 652 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1236 0330-0013 258 µM 1.12847038177642 0.172411561133023 no 598 0.129560659249559 652 4617066 SGTC_1203 3992-3522 103 µM 1.12764182018955 0.172592928435718 no 599 0.129735608749515 714 5322312 SGTC_45 0kpi-0036 14.9 µM 1.1274006094115 0.17264575092362 no 600 0.129786570765545 634 2795021 SGTC_1961 st076550 68.7 µM 1.12684599287464 0.172767244890566 no 601 0.129903800429746 617 1579337 SGTC_2628 lathosterol 100 µM 1.12650322554722 0.172842358537044 no 602 0.129976288028958 688 6710616 SGTC_2658 polymyxin b sulfate 77.05 µM 1.12631376831249 0.17288388491187 no 603 0.130016365996321 706 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2734 clemastine 41.6 µM 1.1262984904133 0.17288723389059 no 604 0.130019598270615 551 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2342 7990637 118.86 µM 1.12486849985798 0.17320087674697 no 605 0.130322381006746 708 2033102 YER133W GLC7 SGTC_3147 9097027 49.47 µM 1.1248416124987 0.173206777476916 no 606 0.130328078739191 722 25236841 SGTC_36 0335-0881 14.2 µM 1.12428960345707 0.173327950292281 no 607 0.130445093722929 738 23828853 SGTC_3033 9090887 49.47 µM 1.12410128796238 0.173369300217117 no 608 0.13048502949585 698 19325384 SGTC_841 0251-0215 91.2 µM 1.12247519676215 0.173726615142267 no 609 0.130830223860833 735 3888614 SGTC_3085 9117376 49.47 µM 1.11501085417949 0.17537282411991 no 610 0.132422885228047 681 16480349 SGTC_1277 0873-0036 22 µM 1.11104733289415 0.176250957872783 no 611 0.133273987980268 734 5965735 SGTC_281 1672-3440 14.9 µM 1.10806690068669 0.176913114019572 no 612 0.13391646217985 751 6833000 SGTC_3299 9121982 43.1275 µM 1.10719683798161 0.177106710038473 no 613 0.134104417181043 704 17594604 YPL160W CDC60 SGTC_142 0335-0849 62.6745 µM 1.10492119559368 0.177613691432825 no 614 0.134596868642595 810 3889043 YPR107C YTH1 SGTC_1005 4092-0690 4.4 µM 1.10482063441196 0.177636116171377 no 615 0.134618658789987 657 1529343 SGTC_1353 1498-1206 8.11 µM 1.10455330460772 0.1776957383283 no 616 0.1346765970485 761 6756808 SGTC_565 1418-0001 44.5 µM 1.1030356017833 0.178034468545539 no 617 0.135005852389185 750 2862145 SGTC_1594 piperine 70.1 µM 1.10252146923729 0.178149308053308 no 618 0.135117515044929 710 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1336 1486-0901 104 µM 1.10115254115501 0.178455307068174 no 619 0.135415136496239 693 5006114 SGTC_828 2074-0507 139 µM 1.0988985355774 0.178959870012819 no 620 0.135906162745837 726 X828 SGTC_723 4182-0001 115 µM 1.09735688072142 0.17930548851759 no 621 0.136242707438245 674 744821 YLR208W SEC13 SGTC_1910 st062352 60.4 µM 1.09731525694188 0.179314825830614 no 622 0.136251801847621 692 2245730 SGTC_360 0957-0399 1.01 µM 1.09704922298116 0.179374511495844 no 623 0.136309937610005 738 6752301 YPR165W RHO1 SGTC_1872 amphotericin b 148 nM 1.09398350203537 0.18006321801471 no 624 0.136981106990109 743 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_2627 acetyl isogambogic acid 100 µM 1.09175613919166 0.180564629304813 no 625 0.137470151187169 656 6857789 A caspase activator and apoptosis inducer. SGTC_2364 9055074 200 µM 1.09156908042892 0.180606778734821 no 626 0.137511276369678 676 6470630 SGTC_1347 1493-0251 600 nM 1.09085213231519 0.180768383794335 no 627 0.13766897639418 763 3986378 SGTC_2639 lactacystin 53 µM 1.09006382332943 0.18094617868802 no 628 0.137842515383753 745 3870 A proteasome inhibitor. SGTC_2379 9035213 200 µM 1.08974156491336 0.181018892267667 no 629 0.137913500575218 778 646551 SGTC_2785 7756463 72.73 µM 1.08856230963869 0.181285132518047 no 630 0.138173472567028 694 2201551 SGTC_2059 5238311 157 µM 1.08606672429716 0.181849368441428 no 631 0.13872473648319 680 703021 SGTC_323 4013-0906 34.3 µM 1.08426709889095 0.182256933152448 no 632 0.139123194321762 715 2910086 SGTC_1828 st055811 49 µM 1.08317310653517 0.182504970519677 no 633 0.139365797195141 690 5877589 SGTC_1573 oleylamine 1.06 µM 1.08214882052721 0.182737394615277 no 634 0.139593202785447 714 5356789 An amine of the fatty acid oleic acid. SGTC_495 decylubiquinone 155 µM 1.08116105913541 0.182961705734092 no 635 0.13981273828126 686 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_3270 9137563 49.47 µM 1.080912268748 0.183018230716785 no 636 0.139868070317455 669 17015724 SGTC_908 3448-7491 47.7 µM 1.08076546333107 0.183051589904488 no 637 0.139900727445714 788 1203031 SGTC_2261 9010538 184.68 µM 1.07608112867661 0.184118021249176 no 638 0.140945487350279 624 6457250 SGTC_3153 9100258 49.47 µM 1.07162339974608 0.185136447220609 no 639 0.141944609414761 666 25236848 SGTC_166 k072-0058 166.424 µM 1.07115797460186 0.185242980994942 no 640 0.142049202112967 739 5846229 SGTC_1261 0712-0010 12.7 µM 1.06981383394467 0.185550862565109 no 641 0.142351557049383 769 2840123 SGTC_1013 4112-3890 241 µM 1.06951315106505 0.185619778795191 no 642 0.142419253085468 740 705171 SGTC_485 niflumic acid 177 µM 1.06919972979019 0.18569163155697 no 643 0.142489840232935 697 4488 A COX2 inhibitor. SGTC_1866 st057638 64 µM 1.06710660450046 0.186171929076791 no 644 0.142961849906517 742 688802 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.06282958300727 0.187155744103694 no 645 0.143929620609567 760 442882 SGTC_1833 st055984 71 µM 1.06019620340553 0.187763079280526 no 646 0.14452767398834 741 676288 SGTC_1272 0839-0021 27 µM 1.05867511983994 0.188114440102776 no 647 0.144873881295751 773 5027250 SGTC_1328 1441-0025 69.2 µM 1.05783397011328 0.188308914578832 no 648 0.145065571357802 700 4562601 SGTC_658 3253-0951 102 µM 1.05636834055149 0.188648065490213 no 649 0.145399982170448 846 1184878 SGTC_1232 0279-0259 161 µM 1.05260282122449 0.189521142577016 no 650 0.146261531814086 754 1560000 SGTC_1567 st069303 68.4 µM 1.0458137168818 0.191101540890547 no 651 0.147823523438174 768 5581319 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.04502143260572 0.191286497514062 no 652 0.148006531970829 798 6708561 SGTC_61 0978-8327 98.565 µM 1.04315535265142 0.191722562205278 no 653 0.148438173919696 801 6150059 YHR072W ERG7 SGTC_858 0438-0351 2.77 µM 1.04179881480445 0.192039939117786 no 654 0.148752481879999 811 2799119 SGTC_926 2268-1401 59.4 µM 1.04122423223433 0.192174465888039 no 655 0.148885745884009 762 2931578 SGTC_373 0844-0104 25.9 µM 1.03883049763338 0.192735530069935 no 656 0.149441787447686 819 5375804 SGTC_1737 st035557 69.7 µM 1.03814848041452 0.192895570180411 no 657 0.149600466903159 637 5716916 SGTC_2197 6588183 93.1375 µM 1.03788685032766 0.19295698504527 no 658 0.149661368095555 728 884136 SGTC_635 k038-0028 24.7 µM 1.0349723807737 0.193641932776059 no 659 0.15034090492307 796 4035102 SGTC_837 0091-0265 12.5 µM 1.03215253840931 0.194306050875971 no 660 0.151000332449012 801 759367 SGTC_1837 st055472 66.5 µM 1.03104895941467 0.194566338578911 no 661 0.151258930576706 780 676091 SGTC_2502 avocadyne acetate 18.59 µM 1.02802236362184 0.195281272982703 no 662 0.151969654042174 819 3952079 SGTC_2456 5770359 74.46 µM 1.02550909747765 0.195876161391546 no 663 0.152561517514523 806 3118787 SGTC_1516 st013856 110 µM 1.02238041559209 0.196618252900983 no 664 0.153300443031074 739 5281404 A mutagen and neurotoxin. SGTC_1054 3429-0080 167 µM 1.02234268388467 0.196627212859575 no 665 0.153309368873245 801 1162877 SGTC_2351 9026858 72.31 µM 1.02031759984241 0.197108462186714 no 666 0.153788929500996 723 1409300 SGTC_618 k072-0232 33.2 µM 1.01938865264182 0.197329459302262 no 667 0.154009245565285 758 5872756 YGL099W LSG1 SGTC_372 0155-0182 15.9 µM 1.01839019564641 0.19756715987615 no 668 0.154246279833379 835 771486 SGTC_1723 st034307 2.5525 µM 1.0183526389205 0.197576104304135 no 669 0.154255200527644 780 867466 SGTC_72 0744-0168 198.391 µM 1.01793383939332 0.197675861270285 no 670 0.154354699367996 755 677577 SGTC_3066 9117245 49.47 µM 1.01689584582398 0.197923239848342 no 671 0.154601489882132 808 17176980 SGTC_817 1391-0715 46 µM 1.01489444228541 0.198400749536909 no 672 0.155078073877374 750 1353946 SGTC_435 c-PAF 6.7 µM 1.01445955850924 0.198504599190919 no 673 0.155181758682124 797 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_1340 1486-1359 257 µM 1.01361135234802 0.198707243997391 no 674 0.155384119278414 783 4309068 SGTC_1771 st048882 4.1505 µM 1.01348619384288 0.19873715615465 no 675 0.155413993677154 777 4580403 SGTC_6 0844-0013 19.835 µM 1.01003717570556 0.199562519362683 no 676 0.156238739707369 1001 1584900 SGTC_1950 st077106 7.18 µM 1.0099144106344 0.199591935483662 no 677 0.156268148933934 800 13831864 SGTC_2118 5526350 200 µM 1.00909074968737 0.199789362922249 no 678 0.156465556945347 820 743594 SGTC_307 1501-1223 22.3 µM 1.00847073840554 0.199938054012231 no 679 0.156614264230815 787 2830329 SGTC_425 3825-7017 13.1 µM 1.00803973956191 0.20004145533979 no 680 0.15671769242134 825 3397440 SGTC_2177 5811945 192 µM 1.00708531993872 0.200270545416761 no 681 0.156946887559644 782 5343475 SGTC_978 1416-0512 87.4 µM 1.00480034445427 0.200819649953949 no 682 0.15749649899805 821 6814003 SGTC_506 n9-isopropylolomoucine 153 µM 1.0046652462066 0.200852143801298 no 683 0.157529034105842 816 6610355 SGTC_140 0062-0056 502.533 µM 1.0031254634238 0.201222715408753 no 684 0.157900165128546 859 3758964 SGTC_589 1227-0070 34.1 µM 1.00285122982154 0.201288756780156 no 685 0.15796632333633 799 2841384 SGTC_185 k048-0037 25.491 µM 1.00176318399262 0.201550909727134 no 686 0.158228991144554 825 6827589 SGTC_1770 st043884 66.3 µM 0.999650633937157 0.202060489747519 no 687 0.158739805057873 805 670149 SGTC_190 3970-0790 3.722 µM 0.99808039795821 0.202439754208859 no 688 0.159120187243597 771 2832352 SGTC_2933 9026794 32.47 µM 0.997055415391486 0.202687551197881 no 689 0.159368806214153 809 17586027 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.997000524486841 0.202700826584698 no 690 0.159382127680483 835 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_3290 9121031 71.43 µM 0.996153214926438 0.202905814640749 no 691 0.159587853610155 734 17014854 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.99371062079705 0.203497439551768 no 692 0.160181885274547 672 88881 An O-methylated flavonoid and antioxidant. SGTC_681 1642-0006 26.6 µM 0.991917013417637 0.203932526750106 no 693 0.160619004503829 798 4446530 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.990796430483143 0.204204635087493 no 694 0.160892496319483 791 6710655 SGTC_1443 4112-3303 14 µM 0.98992810549652 0.204415636875396 no 695 0.161104630459053 821 704433 SGTC_2288 7946289 167.31 µM 0.987899096280441 0.20490918900283 no 696 0.161601034051346 878 1246052 SGTC_602 3130-1533 38.1 µM 0.987792936645848 0.204935031595902 no 697 0.161627033765364 870 720941 SGTC_1557 sumaresinolic acid 42.3 µM 0.987407887845272 0.205028780839926 no 698 0.161721359519463 757 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1769 st044406 64.4 µM 0.987015419411337 0.205124362798055 no 699 0.161817539780799 814 670903 SGTC_3048 9093155 49.47 µM 0.986649405200141 0.205213525940518 no 700 0.161907270620801 762 25236002 SGTC_2234 tolnaftate 200 µM 0.985199983352942 0.205566839428911 no 701 0.16226292440551 787 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1650 st011916 45.8 µM 0.983059413419155 0.206089288306447 no 702 0.162789099073437 829 242528 SGTC_1913 st060213 96.1 µM 0.982789257722631 0.206155281112603 no 703 0.162855584966353 845 688959 SGTC_832 4083-0019 164 µM 0.980667329468937 0.206674054758768 no 704 0.163378409938455 991 1990758 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.980514226365592 0.206711515616269 no 705 0.163416175359712 736 6857784 SGTC_668 1682-0499 62.6 µM 0.977986216079483 0.207330643462001 no 706 0.16404057073509 869 682214 SGTC_1664 st014217 9.02 µM 0.977882117877826 0.207356161339736 no 707 0.164066315171696 906 3982782 SGTC_1091 telmisartan 47.6 µM 0.97690195276779 0.207596522942237 no 708 0.164308847473968 850 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1471 k673-0312 37 µM 0.976648836922456 0.20765862017081 no 709 0.164371516269905 828 24099884 SGTC_1246 0422-0085 105 µM 0.975845063317226 0.207855883702797 no 710 0.164570624800457 855 264295 SGTC_2583 asiatic acid 100 µM 0.975375643873098 0.207971140617105 no 711 0.164686980327388 801 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1424 4048-1941 275 µM 0.973072185673455 0.208537257073319 no 712 0.165258713370874 918 X1424 SGTC_15 0266-0086 27.098 µM 0.972542420790045 0.208667584759195 no 713 0.165390385864872 929 1712902 YIL048W NEO1 SGTC_2411 st077133 39.94 µM 0.971355739362874 0.208959694924857 no 714 0.165685580503327 879 1403142 YNL221C POP1 SGTC_1263 0774-1208 64.8 µM 0.971255363349003 0.208984414246104 no 715 0.1657105652999 909 906585 SGTC_421 streptovitacin 30 mM 0.970057191252327 0.209279617713648 no 716 0.166008992817334 859 91467 include heat shock SGTC_292 k038-0015 474 µM 0.964934046916795 0.210544614128631 no 717 0.16728892345734 805 46368540 SGTC_2747 doxorubicin 7.63 µM 0.964839113051518 0.210568097273343 no 718 0.167312700937116 656 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2399 5884133 200 µM 0.964093875833638 0.210752494920317 no 719 0.167499431406455 796 722445 SGTC_412 gemfibrozil 100 µM 0.963511703114449 0.210896610606251 no 720 0.167645396970234 791 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.963170897851333 0.210981003072586 no 721 0.167730883556178 854 5282309 SGTC_572 0960-0087 17.7 µM 0.962956433657821 0.211034120270718 no 722 0.167784693509117 918 6796365 SGTC_2744 captopril 92.04 µM 0.96266573870386 0.21110613035617 no 723 0.167857647816716 790 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2988 9073640 71.4286 µM 0.959489442057083 0.211893890938772 no 724 0.168656117969608 796 9102229 SGTC_2202 7226349 200 µM 0.959267593385682 0.211948976308644 no 725 0.168711978239137 812 844334 SGTC_3047 9092122 49.47 µM 0.957840766708257 0.212303459714551 no 726 0.169071529426736 795 17173831 SGTC_468 gf-109203x 121 µM 0.957480913503573 0.212392916980098 no 727 0.169162287779242 734 2396 A protein kinase C inhibitor. SGTC_42 0133-0086 60.653 µM 0.957419696200168 0.212408137412295 no 728 0.169177730470112 779 162923 Model of phenazepam hydroxylation. SGTC_1342 1486-1464 234 µM 0.955451872461169 0.212897736000184 no 729 0.169674616288662 855 3253938 SGTC_3022 9087993 49.47 µM 0.954286580063683 0.213187973363774 no 730 0.169969299571366 863 17173644 SGTC_3356 9151811 4.48 µM 0.951931084641297 0.213775356694459 no 731 0.17056596681505 833 1859254 YPR165W RHO1 SGTC_546 peri-Naphthalide 147 µM 0.950405570970127 0.214156272150595 no 732 0.170953107180824 847 223824 A penicillin ester. SGTC_1299 1079-1439 3.74 µM 0.948388117377515 0.21466062930958 no 733 0.171465953210819 817 323161 SGTC_2606 farnesol 9.78 µM 0.948055356977982 0.214743884651672 no 734 0.171550636809686 850 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3000 9075062 71.4286 µM 0.947288734821754 0.21493576188675 no 735 0.171745834797478 813 17057871 SGTC_3305 9127027 53.8275 µM 0.947181233881643 0.214962676167722 no 736 0.171773218115638 859 41905295 SGTC_2853 9015042 58.44 µM 0.947133505416879 0.21497462624698 no 737 0.171785376705333 796 6457456 SGTC_3057 9095946 49.47 µM 0.94712922542779 0.214975697873916 no 738 0.171786467038182 879 24540043 SGTC_467 ro 31-8220 72.8 µM 0.945064547079412 0.215493015229953 no 739 0.172312961871802 869 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2519 cryptotanshinone 88.04 µM 0.94416072588342 0.215719699999877 no 740 0.172543760708753 869 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_3177 9107506 49.47 µM 0.942217289619409 0.21620759552176 no 741 0.173040701880591 834 8897194 SGTC_3100 9120536 49.47 µM 0.941056667526897 0.216499271691475 no 742 0.173337910046238 757 16421196 SGTC_3138 9097216 49.47 µM 0.940546759830329 0.21662748865042 no 743 0.173468588173451 944 25237486 SGTC_12 0849-0099 9.267 µM 0.940030096849316 0.21675744902353 no 744 0.173601061469911 846 6071388 SGTC_3174 9107204 49.47 µM 0.937730865861018 0.217336339464023 no 745 0.174191368714357 844 3938802 SGTC_3192 9110362 49.47 µM 0.934050300288296 0.218264872327174 no 746 0.175138973490566 899 16649480 SGTC_2295 7971645 200 µM 0.933730949895565 0.218345545646051 no 747 0.175221347875507 851 2978226 YKL099C UTP11 SGTC_3170 9103054 49.47 µM 0.933001991458567 0.218529757234365 no 748 0.175409470065093 810 16432970 SGTC_2066 5222451 176 µM 0.929989871117438 0.219291883896308 no 749 0.176188164428264 937 2281147 SGTC_98 0074-0023 107.663 µM 0.928375440105776 0.219700995217058 no 750 0.176606426878566 905 3563821 SGTC_1161 k007-0610 110 µM 0.927591707385353 0.219899758028948 no 751 0.17680970045747 969 5843850 SGTC_1169 aniline yellow 25.8 µM 0.926065839910929 0.220287029867499 no 752 0.177205882586886 852 6051 A DNA damaging agent. SGTC_2870 9038528 12.99 µM 0.925555346846698 0.220416682485559 no 753 0.177338554052526 773 6463316 SGTC_2363 9053361 176 µM 0.925309531040327 0.22047912922106 no 754 0.177402461210136 885 6469797 YMR079W SEC14 SGTC_2124 5246320 200 µM 0.924517347012163 0.220680443618247 no 755 0.177608512012497 855 579342 SGTC_1253 0550-0034 176 µM 0.924014625282997 0.220808252768266 no 756 0.177739350606066 814 5969915 SGTC_3121 9125696 49.47 µM 0.922448698214728 0.22120663680509 no 757 0.178147289096607 903 1235365 SGTC_1171 0368-0077 21.4 µM 0.922238623616655 0.221260112680987 no 758 0.178202060337154 836 3239779 SGTC_738 1315-0003 72.4 µM 0.920235247772151 0.221770456586023 no 759 0.178724919245787 909 6251474 SGTC_1936 st074407 74.3 µM 0.919825042409673 0.221875035986975 no 760 0.178832097315075 918 809813 SGTC_773 4358-1457 44.6 µM 0.919341172806616 0.221998431843725 no 761 0.178958574302577 947 1186886 SGTC_2653 dihydrofissinolide 100 µM 0.917706354139791 0.222415631082711 no 762 0.179386310082103 888 6857746 SGTC_1500 4488-1866 171 µM 0.91748678593368 0.22247169806143 no 763 0.179443807075176 961 2900003 SGTC_1735 st034310 56.75 µM 0.913919620024863 0.22338370618803 no 764 0.180379541684871 868 871153 SGTC_1749 st037932 54.2 µM 0.912662238771408 0.223705683996363 no 765 0.180710104850308 839 594497 SGTC_863 0466-0191 129 µM 0.910076529070211 0.224368635592442 no 766 0.181391075793787 930 765160 YPR165W RHO1 SGTC_2292 7671323 168.05 µM 0.909986119217733 0.224391835986512 no 767 0.181414915111213 880 937504 SGTC_249 wiskostatin 11.211 µM 0.909485064586748 0.224520438079929 no 768 0.181547069014899 910 2775510 A n-wasp and actin depolymerizer. SGTC_1943 st076331 65.2 µM 0.906060171029722 0.225400599984722 no 769 0.182452002541699 939 24208415 SGTC_3069 9117009 49.47 µM 0.905699759911395 0.225493335346781 no 770 0.182547394815249 790 41904981 SGTC_786 4544-0069 423 µM 0.904860436419592 0.225709380649653 no 771 0.182769664542921 920 748821 YLR208W SEC13 SGTC_1075 aripiprazole 15.2 µM 0.903542053366926 0.226048974160164 no 772 0.183119139816978 955 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2027 5150920 200 µM 0.901237080984793 0.226643389936124 no 773 0.183731139603598 904 786715 SGTC_553 k007-0256 45.7 µM 0.90122504008037 0.226646497408713 no 774 0.183734339960418 920 6287000 SGTC_1383 3049-0032 20.7 µM 0.900896964048761 0.226731175324551 no 775 0.183821552784603 936 712864 SGTC_1382 3002-2117 298 µM 0.899657031011591 0.227051368863195 no 776 0.184151398419959 979 1497314 SGTC_2994 9053520 71.4286 µM 0.897560890858409 0.2275932440293 no 777 0.184709848543048 920 4647384 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.896216286525931 0.227941221971261 no 778 0.185068629463925 889 4330530 SGTC_1146 3579-1023 7 µM 0.89452029446399 0.228380564125123 no 779 0.18552178816204 984 X1146 SGTC_480 am 92016 50 µM 0.89424771347471 0.228451219852107 no 780 0.185594684315369 860 2129 K+ channel blocker. SGTC_1030 k029-0042 36.7 µM 0.893891546016706 0.228543560535663 no 781 0.185689960723112 933 6080581 SGTC_2987 9018338 71.43 µM 0.892810851385951 0.228823871854258 no 782 0.185979237103561 922 5055682 SGTC_1337 1486-1011 40.3 µM 0.892180845877872 0.228987372119845 no 783 0.186148003519701 966 X1337 SGTC_1405 3909-7894 12 µM 0.890631996800372 0.229389611004317 no 784 0.186563313900288 936 7104060 SGTC_1521 st012942 49.4 µM 0.887663649417079 0.230161601838191 no 785 0.187360852396471 971 24207259 SGTC_3129 9127257 49.47 µM 0.887361975731016 0.230240140685441 no 786 0.187442024196229 787 837894 SGTC_341 1486-1430 230 µM 0.886605584257936 0.230437128341884 no 787 0.187645643157919 915 2054753 YPL210C SRP72 SGTC_1701 st028638 40.4 µM 0.88651193060921 0.230461525192259 no 788 0.187670864023243 946 3490878 SGTC_2009 4012297 12.05 µM 0.885752094952214 0.230659516356763 no 789 0.18787556467133 849 45595307 SGTC_3149 9097855 49.47 µM 0.885293825734849 0.230778973968826 no 790 0.187999089580636 905 25236625 YMR079W SEC14 SGTC_1670 st016595 4.04 µM 0.883674075953303 0.231201472962844 no 791 0.188436089265434 969 597879 SGTC_1459 k035-0031 35.7 µM 0.883038954188976 0.231367257191311 no 792 0.188607612516492 815 3877128 YMR208W ERG12 SGTC_386 1509-0011 3.07 µM 0.882642317464329 0.231470823893046 no 793 0.188714778457291 987 3107280 SGTC_1003 4049-0218 100 µM 0.882404670485071 0.231532888807741 no 794 0.188779005471204 944 295161 SGTC_1748 st037455 53.6035 µM 0.880101905481331 0.232134769129556 no 795 0.189402053490955 901 580690 SGTC_1781 st038725 66.3 µM 0.879641840347554 0.232255121968081 no 796 0.189526682610474 970 4270275 YIL048W NEO1 SGTC_853 0419-0306 21 µM 0.878556879142536 0.232539084786733 no 797 0.18982079239756 852 762713 SGTC_2601 securinine 100 µM 0.877096560858673 0.232921592988218 no 798 0.190217096267301 877 442872 A GABA receptor antagonist. SGTC_682 0kpi-0099 17 µM 0.875609748388131 0.233311399746817 no 799 0.190621112010497 939 1714895 YML126C ERG13 SGTC_924 2046-0044 21.3 µM 0.873702259219478 0.233812027599698 no 800 0.19114021014729 987 3623589 SGTC_1614 st002383 48.6 µM 0.872899455915095 0.234022904279171 no 801 0.191358941439334 939 1947235 SGTC_416 estradiol valerate 100 µM 0.872815033115027 0.234045086191953 no 802 0.191381952133927 931 13791 A steroid. SGTC_1505 k297-0037 20.6 µM 0.87181733311785 0.234307317945165 no 803 0.191654018579677 928 4089396 SGTC_543 3844-1095 191 µM 0.871403275329766 0.23441619508398 no 804 0.191766999024909 951 4230703 SGTC_1019 4262-0212 3.4 µM 0.870542753957926 0.23464256003688 no 805 0.192001932623518 1051 4677213 SGTC_1591 genipin 88.4 µM 0.86958498042229 0.234894649797328 no 806 0.19226362436404 917 442424 A DNA cross-linking agent. SGTC_2600 tangeritin 87.95 µM 0.869127830667324 0.235015026159924 no 807 0.192388607924626 892 68077 A bioactive flavone. SGTC_1967 st070177 51.4 µM 0.868191250838452 0.235261752127659 no 808 0.192644821536757 925 5729214 SGTC_931 2812-0076 566 µM 0.867796905927834 0.235365678330456 no 809 0.192752762078829 960 3450959 SGTC_801 0866-0028 10.1 µM 0.867377203340709 0.235476315161775 no 810 0.192867684137838 984 6849771 SGTC_793 0488-0545 106 µM 0.867020990359288 0.235570238154301 no 811 0.192965254437764 936 292548 SGTC_1433 4060-0023 7.6 µM 0.864010152375042 0.236364933505217 no 812 0.193791156740506 965 3840627 SGTC_819 1013-0258 27.7 µM 0.862240244523183 0.236832779609558 no 813 0.194277663912007 955 5753198 SGTC_547 1120-0019 610 nM 0.860654328485575 0.237252422662286 no 814 0.194714227126957 934 3676939 SGTC_231 b-estradiol 524 µM 0.860286713809808 0.23734975402017 no 815 0.194815507436969 889 450 A steroid. SGTC_213 1246-0773 967 nM 0.858583181628885 0.237801075154767 no 816 0.195285260119343 964 6251622 SGTC_1699 st031318 29.054 µM 0.857261439316469 0.238151571741883 no 817 0.195650207135218 1000 5340658 SGTC_1120 ficusin 1.78878 µM 0.855279372220348 0.238677701842315 no 818 0.196198252182302 959 6199 A DNA cross-linker. SGTC_1497 4476-2978 41.3 µM 0.854359860405596 0.238921997598019 no 819 0.196452814600015 1009 1528379 SGTC_2974 9094440 9.66 µM 0.852315622573724 0.239465599951425 no 820 0.197019468702813 983 25236134 SGTC_704 1310-0270 142 µM 0.852086507447034 0.239526568153309 no 821 0.197083040043614 1010 5718033 SGTC_158 k038-0087 26.446 µM 0.851329009365457 0.239728200911658 no 822 0.197293307308649 996 X158 SGTC_2390 9097792 176.6 µM 0.849811863433596 0.240132317025095 no 823 0.197714846426331 922 4497149 SGTC_1326 1431-2094 10.8 µM 0.84886578825807 0.240384507152081 no 824 0.197977988810008 941 616278 SGTC_1485 3909-9022 254 µM 0.847794866161283 0.240670151043071 no 825 0.198276111350119 1042 714516 SGTC_643 k048-0106 28.4 µM 0.847755658731233 0.240680612229812 no 826 0.198287031026013 962 6763920 SGTC_2508 celastrol 40.54 µM 0.846069266223111 0.241130803647099 no 827 0.198757052315074 918 122724 Celastrol is a natural product and antioxidant. SGTC_2015 5119600 184 µM 0.844074829074446 0.241663819527812 no 828 0.199313796129028 978 2828786 SGTC_8 0354-0001 70 µM 0.842813690074665 0.242001190350382 no 829 0.199666325132372 1062 4993152 SGTC_945 3381-0768 11.3 µM 0.840893267464037 0.242515418256323 no 830 0.200203865216681 1022 1126236 YIL048W NEO1 SGTC_1004 4084-0029 199 µM 0.839842075751828 0.242797144295937 no 831 0.200498469282505 1027 716894 YLR208W SEC13 SGTC_2426 5582046 32.21 µM 0.839532544315191 0.242880134426417 no 832 0.200585267296018 979 2251934 SGTC_2298 7976326 193.81 µM 0.839470960204181 0.242896647902605 no 833 0.200602539245525 904 2235818 SGTC_383 2324-0395 7.37 µM 0.837478036677771 0.243431368310035 no 834 0.201161958737038 1010 3146421 SGTC_3017 9080681 49.47 µM 0.833212101891875 0.244578093877403 no 835 0.202362559273003 965 16451914 SGTC_2656 pseudo-anisatin 100 µM 0.83254815547006 0.244756830548336 no 836 0.202549804337266 1002 6708809 A neurotoxin. SGTC_410 α-linolenic acid 100 µM 0.82895030252768 0.245726606766243 no 837 0.203566264763143 1015 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2596 sinensetin 100 µM 0.82887879091824 0.245745903111596 no 838 0.203586498909888 936 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_629 3448-6466 76.7 µM 0.828611319241003 0.2458180835814 no 839 0.20366219041709 1021 573744 SGTC_3238 9133470 49.47 µM 0.827581187813696 0.246096183302886 no 840 0.203953862866125 1010 3534688 SGTC_1545 lovastatin 49.4 µM 0.826762058263178 0.246317440233509 no 841 0.204185969585608 1041 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_3183 9108214 49.47 µM 0.82557554650461 0.24663812060727 no 842 0.20452245573562 924 4974831 SGTC_992 3909-8734 162 µM 0.821245512370288 0.247810300174218 no 843 0.205753218598004 1002 4288319 SGTC_2623 humulene 100 µM 0.820645488371763 0.247972966419169 no 844 0.205924114627436 898 6187145 An anti-inflammatory. SGTC_3267 9137951 49.47 µM 0.81961440852425 0.248252624745255 no 845 0.206217978550599 1011 16643986 SGTC_1778 st046819 58.9 µM 0.817121027161417 0.248929595497737 no 846 0.206929633779967 1108 671715 SGTC_1050 3232-1156 69.3 µM 0.815756774803447 0.249300415135202 no 847 0.207319629995723 962 700529 SGTC_3040 9091894 49.47 µM 0.81461768479402 0.249610257867279 no 848 0.207645592163258 949 25236966 SGTC_633 0437-0093 97.7 µM 0.812518622170803 0.250181757156072 no 849 0.208247052738205 1053 2831118 SGTC_3211 9128781 49.47 µM 0.811599767564863 0.250432146437956 no 850 0.20851066235584 925 17194361 SGTC_427 1354-0053 47.3 µM 0.80994771957646 0.250882665885558 no 851 0.208985111957353 1000 6813657 SGTC_2327 6189656 200 µM 0.808508521814256 0.251275489683762 no 852 0.20939895115591 1026 5349088 SGTC_43 0570-0105 72.5 µM 0.806466113781861 0.251833515281453 no 853 0.209987069575131 1065 1114046 YDL195W SEC31 SGTC_1809 st050081 57.6 µM 0.806125152563683 0.251926736200531 no 854 0.210085344988957 1038 5036894 SGTC_1122 capsaicin 818.572 nM 0.80606699012276 0.251942639991999 no 855 0.21010211187429 1024 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_121 0557-0495 61.343 µM 0.805360912301648 0.25213575038617 no 856 0.210305720455979 1205 3104427 SGTC_3135 9127742 49.47 µM 0.80522789727013 0.252172138378635 no 857 0.210344090385527 955 3643468 SGTC_2400 5203494 178.7 µM 0.804689474948351 0.252319459101467 no 858 0.210499447348543 985 6777674 SGTC_3295 9122362 53.5725 µM 0.804577119018706 0.252350207152668 no 859 0.210531875141775 1003 4730473 SGTC_772 k072-0172 35.3 µM 0.803600703729159 0.25261750243082 no 860 0.210813808284855 987 5861980 SGTC_275 trichlorophene 5.69 µM 0.803250665409888 0.252713362294342 no 861 0.210914933315842 1098 62616 SGTC_766 1391-0721 126 µM 0.803129886417104 0.252746442711198 no 862 0.210949832607284 1039 1020919 YIL115C NUP159 SGTC_282 k297-0036 65.7 µM 0.803072987565584 0.252762027649496 no 863 0.210966274798469 1022 5061378 SGTC_1183 1254-0324 198 µM 0.801336031396415 0.253238033801526 no 864 0.211468568452448 1050 5799357 SGTC_2183 6420625 130.508 µM 0.799395597132312 0.253770359242216 no 865 0.212030531314847 1099 2897619 SGTC_518 1021-0119 62.6 µM 0.799389924133322 0.25377191639475 no 866 0.212032175532984 953 1097762 SGTC_2144 5628481 200 µM 0.798127101803156 0.254118666859484 no 867 0.21239836772168 1038 2818399 SGTC_860 0443-0016 25.1 µM 0.797074998933323 0.25440774684543 no 868 0.212703737645227 1096 5337942 SGTC_1832 st054113 55 µM 0.796974684694629 0.254435318583082 no 869 0.212732866953176 1040 1251267 SGTC_888 0916-0002 6.97 µM 0.796554495281963 0.254550826203944 no 870 0.212854907110666 1062 2802138 YIL048W NEO1 SGTC_1139 k015-0024 46.9 µM 0.795247491510565 0.254910289463703 no 871 0.213234775498233 1070 2766652 SGTC_1463 k081-0032 34.1 µM 0.791075408958467 0.256059505949896 no 872 0.214449994098895 911 977755 SGTC_245 methotrexate 289.6 µM 0.790036293214176 0.256346154243133 no 873 0.214753286559855 1043 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2228 7354201 200 µM 0.789387955252552 0.256525088085553 no 874 0.214942646745717 1098 753451 SGTC_2263 7948595 193.29 µM 0.788784010098576 0.256691828534897 no 875 0.215119128325337 970 2971371 SGTC_1885 st057546 99.9 µM 0.788460844643994 0.256781072974528 no 876 0.215213596521946 1083 702008 SGTC_1710 st031758 61.5 µM 0.785960837028569 0.257472013227241 no 877 0.215945215583519 1036 5394341 SGTC_25 0118-0223 35.662 µM 0.782370462702585 0.258465990755402 no 878 0.216998443698275 1065 5333628 SGTC_446 go6976 132 µM 0.781498429030466 0.258707708668412 no 879 0.217254700161799 1061 3501 A protein kinase C inhibitor. SGTC_527 4476-4215 268 µM 0.778725008479916 0.259477246750337 no 880 0.218070860548227 1037 4418754 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.77738393402047 0.259849776857164 no 881 0.218466144141189 1086 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2715 st079500 56.4 µM 0.776698651991167 0.260040244259956 no 882 0.218668291180234 1015 28246688 SGTC_2984 9022109 38.96 µM 0.775919173074173 0.260256980237552 no 883 0.218898355595066 1052 6459207 SGTC_1416 3966-0321 25.3 µM 0.773707034857958 0.260872577106817 no 884 0.219552029465279 1109 582530 YLR208W SEC13 SGTC_2665 lovastatin 100 µM 0.77320155340687 0.261013348231369 no 885 0.219701553482998 1090 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_188 3229-0966 278.469 µM 0.772830969007072 0.261116576791143 no 886 0.219811211393226 1194 5722370 SGTC_2595 hexamethylquercetagetin 100 µM 0.772824834595916 0.261118285745571 no 887 0.219813026862661 1007 386331 SGTC_2435 5706476 10.6 µM 0.77236429783675 0.261246600755395 no 888 0.219949346575742 1113 5725375 SGTC_684 1140-0066 328 µM 0.771698860536405 0.261432062477167 no 889 0.22014640288048 1119 6813534 SGTC_736 0958-0254 92.6 µM 0.771529578798599 0.261479253188266 no 890 0.220196548523356 1115 6812352 SGTC_951 1171-0579 82.7 µM 0.771469707253562 0.261495944640329 no 891 0.220214285596344 1117 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_533 1222-0222 6.71 µM 0.770751683809924 0.261696163376598 no 892 0.220427065395786 1121 3982874 SGTC_2306 7482397 179.52 µM 0.769805796335858 0.261960041345801 no 893 0.220707550437332 1072 891448 SGTC_997 3996-0078 137 µM 0.767634083801118 0.262566408336378 no 894 0.221352303590376 1117 735687 SGTC_1782 st039423 80.636 µM 0.767504293596407 0.262602669981933 no 895 0.221390870690079 1023 2068169 SGTC_871 0574-0004 149 µM 0.767384439347683 0.262636157930238 no 896 0.22142648873714 1042 9551173 SGTC_2100 5377183 190 µM 0.766340089815153 0.262928047484242 no 897 0.221736985071388 1126 2844202 SGTC_197 4544-0043 41.561 µM 0.765119627940628 0.263269369437105 no 898 0.222100156502388 1119 896523 SGTC_824 1304-0008 100 µM 0.764767401808469 0.263367917248541 no 899 0.2222050311248 1072 768245 SGTC_475 α-linolenic acid 10 µM 0.764279599956524 0.263504428295987 no 900 0.222350319803857 1193 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1073 triclabendazole 3.09 µM 0.763986310610823 0.263586522518588 no 901 0.222437700249918 1116 50248 An antihelmetic and likely tubulin inhibitor. SGTC_151 3013-0144 2.285 µM 0.763611120496044 0.263691560496312 no 902 0.222549510148562 1065 906558 YHR107C CDC12 SGTC_1761 st044296 37 µM 0.763417150058078 0.263745872703698 no 903 0.222607327580139 1132 1826700 SGTC_1415 3966-0071 78.1 µM 0.761665125948957 0.264236702191784 no 904 0.223129947229705 1092 2893185 SGTC_250 brefeldin a 552.239 µM 0.760284848989928 0.264623714053804 no 905 0.223542168150256 1005 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1265 0819-1001 68.8 µM 0.758735738757375 0.265058407712565 no 906 0.224005326721903 1099 3106768 SGTC_2505 galangin 7.89 µM 0.757532032743991 0.265396428238344 no 907 0.224365591180108 1008 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2155 5570423 76 µM 0.757486640405268 0.265409179435635 no 908 0.224379183359865 1039 797402 SGTC_2544 sphondin 68.51 µM 0.756838599215798 0.26559125508739 no 909 0.224573282313875 1108 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2958 9077254 16.72 µM 0.756349972666026 0.265728582989876 no 910 0.224719696939975 1113 16457351 SGTC_2460 5552655 174.22 µM 0.756137539259121 0.265788298368238 no 911 0.224783368482254 1116 5401989 SGTC_247 mechlorethamine 29.705 µM 0.7547103490396 0.266189660153266 no 912 0.225211397790972 1053 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2982 9019404 25.97 µM 0.752514929680925 0.266807665771405 no 913 0.225870727504876 1025 22333232 SGTC_1787 fluconazole 80 µM 0.752423152502915 0.266833516620449 no 914 0.225898313833186 1054 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1473 k844-0725 134 µM 0.751579036960609 0.267071337715376 no 915 0.226152126893834 1196 54682906 SGTC_1464 k208-0027 110 µM 0.751428258172994 0.267113829390937 no 916 0.226197480803339 1099 X1464 SGTC_1421 4029-0249 71.4 µM 0.751409380381422 0.267119149670103 no 917 0.226203159561231 1189 2894095 SGTC_1047 2043-3044 82 µM 0.749906432943621 0.267542893060607 no 918 0.226655529908591 1156 669592 SGTC_2790 5423970 71.43 µM 0.749721730718836 0.267594991674925 no 919 0.226711158417502 1129 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_356 1634-0012 32.5 µM 0.749507880868084 0.26765531829408 no 920 0.226775575214638 1133 735457 SGTC_3346 9158254 43.5805 µM 0.748923056523188 0.267820331081008 no 921 0.226951791315611 1074 17639500 SGTC_2746 daunorubicin 9.88 µM 0.747605509140807 0.268192275127321 no 922 0.227349070377374 1019 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2861 9024595 19.48 µM 0.743710250891032 0.269293425790875 no 923 0.228525893253173 1066 16482810 SGTC_2033 5192550 145 µM 0.741803839341558 0.269833174508465 no 924 0.229103097029228 1122 182073 SGTC_2603 homopterocarpin 100 µM 0.740753706029811 0.270130722449654 no 925 0.229421394610492 1131 101795 A weak amylase inhibitor. SGTC_1048 3161-0300 24.5 µM 0.740184127665199 0.270292177124585 no 926 0.229594138610217 1171 2165101 SGTC_1784 st039334 36.3 µM 0.73904764253548 0.270614473280439 no 927 0.22993903400675 1138 3496984 SGTC_742 0kpi-0133 140 µM 0.738375233473006 0.270805252304396 no 928 0.23014323015505 1147 2728852 SGTC_1744 st037937 38.9 µM 0.738008846533462 0.270909233559426 no 929 0.230254536660594 1157 1016152 SGTC_1480 1070-0044 41.2 µM 0.737741413592355 0.270985144072952 no 930 0.230335800444843 1133 3124987 SGTC_1697 st025554 27.742 µM 0.736886774407984 0.271227803481347 no 931 0.230595603740517 1138 1269519 SGTC_2742 clothiapine 36.27 µM 0.736587638261261 0.27131276338994 no 932 0.230686577346423 1083 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2167 5876490 200 µM 0.734540918537106 0.271894423260565 no 933 0.231309565584334 1139 686534 SGTC_612 0302-0167 22.4 µM 0.733121123123755 0.272298280826539 no 934 0.231742278938677 1178 235821 SGTC_2414 st077232 92.9 µM 0.728536710242186 0.273604338076312 no 935 0.23314255254637 1084 729801 SGTC_2210 7115885 190.385 µM 0.728402930603143 0.273642497168541 no 936 0.23318348492029 1158 2927039 SGTC_2475 5812728 15.03 µM 0.727951816366927 0.273771191685238 no 937 0.233321541130418 1174 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2745 rifampicin 24.3 µM 0.726979334405527 0.274048724513132 no 938 0.233619307711075 1064 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1168 k815-0004 80.5 µM 0.726075994735427 0.274306649579262 no 939 0.233896092111996 1155 642433 SGTC_1882 5615643 20 µM 0.725886759566622 0.274360695922379 no 940 0.233954097013002 1097 2253075 SGTC_2897 9048598 12.99 µM 0.725804636451733 0.274384152257553 no 941 0.23397927210267 1150 6467404 SGTC_289 k017-0060 526 µM 0.725717650018231 0.2744089987529 no 942 0.234005939693935 1145 5512909 SGTC_1321 1326-2144 215 µM 0.724920526805497 0.274636737893073 no 943 0.234250393614385 1143 3513030 SGTC_2555 cholic acid 100 µM 0.723492485810794 0.275044964020208 no 944 0.234688684470375 1134 6708657 Influences liver metabolism. SGTC_3196 9111891 49.47 µM 0.72273902416849 0.275260472293944 no 945 0.234920117691139 1186 18891510 SGTC_127 0180-0333 59.125 µM 0.722065226453962 0.275453265131219 no 946 0.235127188122078 1148 771601 SGTC_2083 5306046 65.942 µM 0.72121344663113 0.275697078777806 no 947 0.23538909993516 1168 539837 SGTC_283 0987-0079 11.7 µM 0.720931134516406 0.27577791126082 no 948 0.235475942952449 1185 411556 SGTC_1681 tripelennamine 100 µM 0.720616962298594 0.275867879718056 no 949 0.235572607349022 1166 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_2584 androsterone 48.74 µM 0.719498139916561 0.27618839024127 no 950 0.235917023948536 1237 2754130 A steroid. SGTC_64 000l-0018 272.079 µM 0.718735508466225 0.276406966974544 no 951 0.23615195024648 1126 6811119 SGTC_1271 0832-2808 169 µM 0.7162328654659 0.277124841436667 no 952 0.236923786340039 1178 3663794 SGTC_797 k781-0471 270 µM 0.714311660693552 0.277676550656926 no 953 0.237517241666781 1167 23738129 SGTC_3301 9125354 19.7965 µM 0.71379233163262 0.277825777591621 no 954 0.237677801079327 1136 41905162 SGTC_1251 0490-5699 265 µM 0.711920775390606 0.278363885670373 no 955 0.238256918201581 1221 3883818 SGTC_2845 9003024 42.97 µM 0.708831893774939 0.279253107470964 no 956 0.239214401587319 1204 2990173 SGTC_2252 omeprazole 400 µM 0.708071545917302 0.27947220661311 no 957 0.239450414276454 1117 4594 A proton pump inhibitor. SGTC_220 paclitaxel 373.376 µM 0.708044457594474 0.279480013827945 no 958 0.239458824862391 1126 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1571 st070080 73.4 µM 0.705696431784933 0.280157148262482 no 959 0.240188470225468 1193 4315245 SGTC_521 r062-0005 13.8 µM 0.704784981139301 0.280420210589374 no 960 0.240472028220059 1121 2832033 SGTC_16 erodoxin 22.806 µM 0.704510017023189 0.280499594037744 no 961 0.240557607056823 1223 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_3 0833-0587 95.581 µM 0.704222613719616 0.280582580363147 no 962 0.240647075142781 1134 5382644 SGTC_893 0958-0369 48.9 µM 0.702453305356877 0.281093721187878 no 963 0.241198256144462 1193 6819948 SGTC_325 2810-4341 181 µM 0.70233290162908 0.281128521323829 no 964 0.24123578964661 1196 774970 SGTC_1296 1068-0102 11.9 µM 0.700969919466649 0.28152260736594 no 965 0.24166089389159 1143 767053 SGTC_1805 st050013 60.3 µM 0.70021155255171 0.281741993219216 no 966 0.241897598998106 1142 4037144 SGTC_2560 caryophyllene 100 µM 0.698159523467226 0.282336031851138 no 967 0.242538718294068 1238 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_167 3672-0051 66.205 µM 0.697479420054681 0.282533046772489 no 968 0.242751407146965 1167 3237971 SGTC_1180 1193-0155 285 µM 0.69739154338426 0.282558508039027 no 969 0.24277889619577 1183 2921347 SGTC_1350 1495-0454 146 µM 0.696646409228275 0.282774446512617 no 970 0.243012052253621 1209 1069057 SGTC_2698 st077697 67.5 µM 0.696598010599735 0.282788475085423 no 971 0.243027200604792 1146 3154499 SGTC_1675 st018485 24.5 µM 0.694013541193875 0.283538081020728 no 972 0.243836858469394 1192 3323024 SGTC_662 k832-1615 104 µM 0.693180344280558 0.28377994632942 no 973 0.244098190852883 1176 5878478 SGTC_473 2-arachidonoylglycerol 10 µM 0.692854746979495 0.283874489469543 no 974 0.244200355546065 1159 5282280 An endocannabinoid. SGTC_774 k060-0086 136 µM 0.692789487913199 0.28389344044831 no 975 0.244220835062885 1236 5911235 SGTC_1152 3909-8331 15.9 µM 0.692330821097188 0.284026652586996 no 976 0.244364799417834 1191 16001939 SGTC_3152 9099253 49.47 µM 0.692081338134606 0.284099123313502 no 977 0.24444312525019 1224 25236131 SGTC_673 1082-0474 110 µM 0.690769091789896 0.284480454980177 no 978 0.244855331046407 1240 3098046 SGTC_2588 indole-3-carbinol 100 µM 0.688050154773881 0.285271340538799 no 979 0.24571059896147 1203 3712 Induces cell cycle arrest. SGTC_632 0781-2353 4.65 µM 0.687651755427042 0.285387315045044 no 980 0.245836053930459 1244 6811515 YHR007C ERG11 SGTC_404 fumagillin 50 µM 0.687151300691951 0.285533029802482 no 981 0.245993694597886 1192 12015870 A methionine aminopeptidase binder. SGTC_2775 cyproheptadine 69.59 µM 0.684461649385152 0.286316767363466 no 982 0.246841849159303 1230 2913 A selective serotonin reuptake inhibitor. SGTC_2891 9063876 19.48 µM 0.682446835060546 0.28690453243175 no 983 0.247478224692183 1181 6472478 SGTC_2388 9080168 200 µM 0.682394871025492 0.286919699028073 no 984 0.247494649029247 1189 15943073 SGTC_204 PMA1.184 62.41 µM 0.682218795990768 0.286971092375751 no 985 0.247550305614072 1246 2252213 YGL008C PMA1 SGTC_2441 5730946 39.09 µM 0.681530216676751 0.287172118982994 no 986 0.247768026857536 1229 1774275 SGTC_1369 1866-0067 208 µM 0.680363795725381 0.287512800618133 no 987 0.248137069554502 1243 3531355 SGTC_783 0848-0141 92.7 µM 0.680038881452517 0.287607733760774 no 988 0.248239921024193 1211 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_478 N-arachidonylglycine 10 µM 0.679907622870911 0.287646088969455 no 989 0.248281477316016 1161 5283389 SGTC_359 0081-0058 15.9 µM 0.678810247293569 0.287966848798534 no 990 0.248629050042445 1307 3494159 SGTC_2123 5259487 200 µM 0.678040885944234 0.288191831629777 no 991 0.248872884997571 1204 2173474 SGTC_1725 st036284 20.55 µM 0.677176067574454 0.288444827717395 no 992 0.249147125189099 1245 707914 SGTC_2453 5731132 22.18 µM 0.676426484918085 0.288664197120076 no 993 0.249384953270077 1272 1362040 SGTC_1419 3993-2473 62.6 µM 0.676009656303466 0.288786218246642 no 994 0.249517257119194 1257 704026 SGTC_750 4073-0104 132 µM 0.673714300176274 0.289458588388845 no 995 0.250246484278981 1107 22330957 SGTC_2731 amoxapine 43.43 µM 0.672383044190668 0.289848884854473 no 996 0.25066993718011 1272 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_225 nsc-122657 1.016 µM 0.669919321033391 0.290571847489297 no 997 0.251454611173268 1194 275685 SGTC_1774 st048371 48.465 µM 0.667143681954198 0.291387349004369 no 998 0.252340180197375 1217 4242727 SGTC_1248 0469-0687 58.6 µM 0.666537739612098 0.291565520867969 no 999 0.252533724807274 1242 4017482 SGTC_1903 st060211 78.3 µM 0.664730655526227 0.292097179021359 no 1000 0.253111391341309 1266 688960 SGTC_332 4112-0506 40.9 µM 0.664490106586761 0.292167984400515 no 1001 0.253188339470309 1257 2790355 SGTC_781 4335-2806 94.4 µM 0.660882848534809 0.293230734352514 no 1002 0.254343723082151 1337 845254 SGTC_2855 9016525 58.44 µM 0.660169730220663 0.293441041205448 no 1003 0.25457245743764 1253 43811474 SGTC_1916 st067606 49.2 µM 0.658547676731896 0.293919663602207 no 1004 0.255093135884185 1277 19590279 SGTC_120 rhodamine 6G 52.259 µM 0.657099860655879 0.294347178128335 no 1005 0.25555835425382 1281 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2114 5491910 81.25 µM 0.654260618324323 0.295186388855389 no 1006 0.256471956683158 1303 2849228 SGTC_630 4356-0227 183 µM 0.653823695549471 0.295315630302211 no 1007 0.256612699235793 1278 779312 SGTC_2207 7258803 200 µM 0.652645532260542 0.295664259877309 no 1008 0.256992412224031 1217 3666799 SGTC_1581 himbacine 57.9 µM 0.652027459963842 0.295847228886052 no 1009 0.257191729008572 1261 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2523 spermine 47.74 µM 0.651277843373589 0.296069208940184 no 1010 0.257433574178311 1241 1103 A DNA binding polyamine. SGTC_496 calpeptin 138 µM 0.650407160984907 0.296327135490203 no 1011 0.257714626465176 1223 73364 A calpain inhibitor. SGTC_264 promethazine 12.5 mM 0.648475436512908 0.296899747325661 no 1012 0.258338746534343 1301 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_286 k060-0067 22.9 µM 0.648257678281619 0.296964328097704 no 1013 0.258409151041684 1236 5985051 SGTC_2093 5331342 194.4 µM 0.647387888536028 0.297222346570016 no 1014 0.2586904662504 1267 33839 SGTC_3162 9099653 49.47 µM 0.647268467070515 0.297257780306819 no 1015 0.258729102986818 1250 25237511 SGTC_989 1501-0895 10.3 µM 0.645969127554833 0.297643434145282 no 1016 0.259149674629893 1269 2830112 SGTC_900 1112-0045 141 µM 0.645968358132803 0.297643662583217 no 1017 0.259149923781926 1198 56211 YIL048W NEO1 SGTC_1141 3253-0389 52.6 µM 0.644217083942956 0.298163815203363 no 1018 0.259717337099471 1256 5402031 SGTC_103 0844-0104 51.839 µM 0.640866777940525 0.299160054279023 no 1019 0.260804621064459 1311 5375804 SGTC_2431 5490079 200 µM 0.639757981189549 0.299490095877455 no 1020 0.261164976967654 1301 5722345 SGTC_1098 clofazimine 15.1 µM 0.639385982947697 0.299600860886076 no 1021 0.261285932675935 1328 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_613 3914-0030 117 µM 0.638863441771507 0.299756482421057 no 1022 0.261455886206137 1096 1145395 SGTC_2551 apiole 73.87 µM 0.637654990404767 0.300116519673438 no 1023 0.261849145420882 1190 10659 A possible DNA adduct former. SGTC_2843 9000894 45.46 µM 0.637211223064815 0.300248781582965 no 1024 0.261993634134075 1158 2242070 SGTC_2268 7933382 153.85 µM 0.63606001145533 0.300592015336994 no 1025 0.262368654082209 1308 935025 YOR257W CDC31 SGTC_1482 3346-2049 8.48 µM 0.635707683714469 0.300697097250996 no 1026 0.262483483666584 1293 3826804 SGTC_469 w7 172 µM 0.634461005266028 0.301069052728624 no 1027 0.262890003784432 1315 45115570 A P450 inhibitor. SGTC_1629 st005085 44.9 µM 0.633722454052274 0.301289502557603 no 1028 0.26313098421767 1283 24207091 SGTC_770 0389-1121 67.2 µM 0.632510216388519 0.301651500331323 no 1029 0.263526767392408 1379 6753108 SGTC_161 4065-0411 162.148 µM 0.632130076555928 0.301765057761851 no 1030 0.263650941695031 1305 1906281 YLR208W SEC13 SGTC_3223 9129970 49.47 µM 0.631802827246638 0.301862830838506 no 1031 0.263757862985437 1353 17248386 SGTC_344 k064-0035 6.43 µM 0.630987861360613 0.302106382036781 no 1032 0.264024230679952 1262 5088750 SGTC_230 MPP+ 141.667 µM 0.629850910196282 0.302446305310492 no 1033 0.264396066597404 1258 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2674 ligustilide 100 µM 0.629628475838005 0.302512828321999 no 1034 0.264468844142721 1265 5319022 A signalling regulator. SGTC_1076 itraconazole 331 nM 0.625935221777187 0.303618319789697 no 1035 0.265678715486308 1305 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_269 exalamide 29 µM 0.624970065821222 0.30390751422329 no 1036 0.265995352369691 1342 3316 A derivative of salicylamide. SGTC_508 roscovitine 141 µM 0.62183904216375 0.304846522728058 no 1037 0.267023855626121 1366 160355 A CDKinase inhibitor. SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.6218340848913 0.304848010458914 no 1038 0.267025485620867 1299 16486 A toxic proline analog. SGTC_1627 st003713 25.6 µM 0.619908490952864 0.305426145788128 no 1039 0.267659017634072 1331 16195070 YER133W GLC7 SGTC_614 0462-0418 107 µM 0.617921123312019 0.306023337165839 no 1040 0.268313667046758 1222 5188303 SGTC_3016 9080866 49.47 µM 0.617693885787228 0.306091653501331 no 1041 0.26838857156739 1303 17066299 SGTC_3208 9114115 49.47 µM 0.615544706496915 0.306738112702888 no 1042 0.26909752723189 1276 650895 SGTC_1379 2144-0755 36.5 µM 0.615464647039081 0.306762205703359 no 1043 0.269123954808793 1340 5392327 SGTC_660 4031-1742 102 µM 0.615377218311873 0.30678851735687 no 1044 0.269152816464432 1244 6738706 SGTC_2890 9046729 58.44 µM 0.614222775652543 0.307136039902146 no 1045 0.269534062479112 1264 903329 SGTC_1987 st072290 61.9 µM 0.613882885652289 0.307238390224042 no 1046 0.26964636014321 1349 54697379 SGTC_2772 vinpocetine 57.06 µM 0.613578648469197 0.307330017229384 no 1047 0.269746898201163 1364 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_943 3253-1379 105 µM 0.6134531580113 0.307367814650324 no 1048 0.269788373179245 1353 668464 SGTC_625 k213-0058 121 µM 0.610761956722384 0.308178889817833 no 1049 0.270678591196479 1386 3655420 SGTC_3232 9132874 49.47 µM 0.609723980435121 0.308491966229102 no 1050 0.271022333210612 1285 3784940 SGTC_2580 diallyl disulphide 81.36 µM 0.608564836058179 0.308841754237206 no 1051 0.271406459117891 1346 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_1002 4049-0206 172 µM 0.608473893414913 0.308869204792569 no 1052 0.271436607841029 1327 4662749 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.608180905725188 0.308957648835538 no 1053 0.271533748589849 1380 688788 SGTC_1689 st020265 53.493 µM 0.60755668707818 0.309146118333419 no 1054 0.271740767454477 1375 5758320 YPR016C TIF6 SGTC_2700 st077718 96.8 µM 0.605808972456951 0.309674070594056 no 1055 0.272320805467519 1329 904970 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.60543613861182 0.309786747688945 no 1056 0.272444622507036 1290 4620898 SGTC_81 0411-0046 9.971 µM 0.605273393330234 0.309835937845205 no 1057 0.272498678507705 1234 12925265 SGTC_1385 3091-4834 14.1 µM 0.604228099168039 0.310151961681257 no 1058 0.272846000862505 1350 4072814 SGTC_2807 7945238 51.95 µM 0.602760303544692 0.310595957149104 no 1059 0.27333407912283 1372 17148797 SGTC_652 0437-0092 114 µM 0.601674278889092 0.310924647931815 no 1060 0.273695487228315 1301 3091274 SGTC_2286 7945697 125 µM 0.601498160165072 0.310977965369915 no 1061 0.273754118418583 1290 1245733 SGTC_1366 1683-0113 21.9 µM 0.59964517592633 0.311539170305208 no 1062 0.274371366445436 1333 708623 SGTC_1911 st060208 74.3 µM 0.599305753689481 0.311642017093172 no 1063 0.274484505871379 1399 688783 SGTC_331 k048-0133 24.5 µM 0.59877005253736 0.31180436735953 no 1064 0.274663117666436 1319 6813582 SGTC_2841 9004761 38.96 µM 0.598391000334117 0.311919265498413 no 1065 0.27478953468013 1256 2991039 SGTC_357 1325-0123 420 µM 0.598272283047414 0.311955254795486 no 1066 0.274829133765222 1342 1098503 SGTC_2130 NSC 7 2.4545 µM 0.593830408242949 0.313303102575036 no 1067 0.276312774279027 1366 21448 SGTC_3326 9140064 16.379 µM 0.590666911846094 0.314264561876248 no 1068 0.277371811093067 1323 1868434 SGTC_1992 st073643 23.3 µM 0.589231613684478 0.314701198452108 no 1069 0.277852956357349 1357 3161292 SGTC_176 1486-1328 72.834 µM 0.589116493171239 0.314736230863443 no 1070 0.27789156506951 1337 22310231 SGTC_291 SEC14.278 35.5 µM 0.588284736653876 0.31498939285606 no 1071 0.278170594424569 1382 1068044 SGTC_1843 st055809 45.5 µM 0.587299978957251 0.315289236268456 no 1072 0.27850112763182 1352 16413835 SGTC_223 busulfan 5 mM 0.586380333204345 0.315569364018373 no 1073 0.278809978738078 1378 2478 A DNA alkylator. SGTC_748 act1.228 77.9 µM 0.586369582950691 0.315572639215497 no 1074 0.278813590056867 1294 4421505 YNR035C ARC35 SGTC_457 grayanotoxin iii 135 µM 0.586286723900173 0.315597883731456 no 1075 0.278841425554309 1320 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_273 hydroxyurea 18.1 mM 0.585679055416787 0.315783047271357 no 1076 0.279045605758721 1393 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_1092 toremifene 6.32 µM 0.585503597725792 0.315836519842943 no 1077 0.279104574105341 1364 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.584414389553804 0.316168553653308 no 1078 0.279470773941808 1416 688664 SGTC_3340 9146634 11.102 µM 0.580743435666541 0.317288696830793 no 1079 0.280706691361481 1353 4907387 SGTC_1147 3809-1045 12.3 µM 0.578967119920628 0.317831318439089 no 1080 0.281305679622653 1312 325925 SGTC_89 0302-0250 142.109 µM 0.578947382026069 0.317837350090686 no 1081 0.281312338867469 1407 4203518 YLR208W SEC13 SGTC_49 0717-0965 32.132 µM 0.577623123283867 0.318242137197189 no 1082 0.281759295979366 1444 5889349 YGL099W LSG1 SGTC_2065 5221596 34.26 µM 0.57743682206789 0.31829910145588 no 1083 0.281822202878115 1383 788581 SGTC_807 1315-0151 48 µM 0.576418949026385 0.318610406525009 no 1084 0.282166019700031 1401 4011080 SGTC_2643 anethole 100 µM 0.57249800532368 0.31981077859709 no 1085 0.283492318402127 1371 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_765 1319-0117 244 µM 0.572384003002973 0.319845708012015 no 1086 0.283530925491421 1330 3487746 YGL099W LSG1 SGTC_1431 4049-0260 9.09 µM 0.571849969357984 0.320009352988155 no 1087 0.283711810474818 1388 3854841 SGTC_3314 9135860 59.4275 µM 0.571182315968234 0.320213992593241 no 1088 0.283938032123465 1369 25252478 SGTC_1202 1988-0068 29.6 µM 0.571176325489333 0.320215828957157 no 1089 0.283940062273943 1327 2850480 SGTC_918 glabranin 770.725 nM 0.570266708080049 0.320494720609385 no 1090 0.28424840872763 1435 124049 Also referred to as licorice root. SGTC_3289 9119912 71.43 µM 0.567267301191229 0.321415066196183 no 1091 0.285266294624056 1405 17014829 SGTC_252 miconazole 1.30953 nM 0.566418968792097 0.321675570000418 no 1092 0.285554501463738 1363 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_836 0330-0104 1.35 µM 0.565361687294176 0.322000360128397 no 1093 0.285913889171504 1397 46494820 SGTC_2630 antimycin a 100 µM 0.563348552200131 0.322619158263876 no 1094 0.286598781427458 1348 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1470 k295-0292 231 µM 0.560442923961878 0.323513157826534 no 1095 0.287588680234472 1448 5045612 SGTC_3328 9140624 29.0385 µM 0.557949328067286 0.324281197242518 no 1096 0.288439493110407 1469 4904392 SGTC_939 1165-0479 45.3 µM 0.557897604302129 0.324297136340905 no 1097 0.288457153769571 1343 1377347 SGTC_2676 harmalol 100 µM 0.557646352684488 0.324374566147958 no 1098 0.288542948841894 1447 5459187 A monoamine oxidase inhibitor SGTC_1940 st075990 51.1 µM 0.557462415127926 0.324431256168323 no 1099 0.288605765754977 1482 1084979 SGTC_1720 st037298 9.481 µM 0.555220722974474 0.325122478010636 no 1100 0.289371848079168 1410 597396 SGTC_1806 st050005 60.3 µM 0.552661853671657 0.32591223697344 no 1101 0.290247489406625 1370 5194765 SGTC_1635 st007035 42.4 µM 0.55184858010952 0.326163406278359 no 1102 0.290526050130067 1440 3716403 SGTC_2232 chlorophetanol 41.5365 µM 0.551190333153761 0.326366755329548 no 1103 0.290751603041592 1478 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2087 5276107 200 µM 0.551177714201843 0.326370654145843 no 1104 0.29075592781331 1393 144405 SGTC_2243 6634756 200 µM 0.550598558436687 0.326549613500208 no 1105 0.290954448647655 1493 885676 SGTC_549 1661-1316 519 µM 0.549661370401936 0.326839289526482 no 1106 0.291275828541059 1483 2857282 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.549613713795026 0.326854022527055 no 1107 0.291292175338915 1432 5357218 A potent inhibitor of glutathione S-transferases. SGTC_456 gingerol 170 µM 0.548396361906674 0.327230457315926 no 1108 0.291709886985239 1454 442793 A herb. SGTC_3351 9150312 21.596 µM 0.544552734868962 0.328420152508977 no 1109 0.293030584848149 1418 4904905 SGTC_1031 k035-0009 16 µM 0.544357788737768 0.32848053954618 no 1110 0.293097643589357 1502 5180959 SGTC_3193 9111931 49.47 µM 0.543606583250378 0.328713276861488 no 1111 0.293356114297707 1447 17087244 SGTC_666 0272-0154 136 µM 0.543338349725218 0.328796396659504 no 1112 0.293448432217266 1423 6870312 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.543189727672332 0.328842455082423 no 1113 0.293499589255556 1439 66535 A nucleotide analog. SGTC_2967 9089538 49.85 µM 0.541761278957079 0.329285268120881 no 1114 0.293991484556484 1503 728216 SGTC_1763 st044482 94.5 µM 0.541079372911888 0.329496740622111 no 1115 0.294226437523354 1459 88505 SGTC_1082 camptothecin 424.86 nM 0.540040984247293 0.329818870154292 no 1116 0.294584384265841 1312 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_891 0929-0073 133 µM 0.537928222860814 0.330474681820023 no 1117 0.295313301518988 1485 5603632 SGTC_3159 9100096 49.47 µM 0.536883197146803 0.33079925570137 no 1118 0.295674149136357 1362 25236875 SGTC_1181 1222-0449 220 µM 0.536452139352373 0.330933174754675 no 1119 0.295823052502047 1475 658318 SGTC_3333 9141820 12.094 µM 0.531969091242701 0.332327227435549 no 1120 0.297373701535143 1429 1939433 SGTC_599 1935-0052 86.5 µM 0.529476715221833 0.333103265011582 no 1121 0.298237396486225 1412 9557311 SGTC_157 1348-1695 65.819 µM 0.528499654652501 0.333407682385288 no 1122 0.298576293353101 1419 5380510 SGTC_2638 epoxomicin 18 µM 0.528107084497612 0.333530024221908 no 1123 0.298712506987829 1510 9915668 A protesome inhibitor. SGTC_1125 tnp00248 1.32998 µM 0.526882813660515 0.333911673622997 no 1124 0.299137484677138 1559 24207736 SGTC_2829 7992743 58.44 µM 0.526595192367675 0.334001360504271 no 1125 0.299237365642947 1498 16462845 SGTC_1669 st015249 58.4 µM 0.526551851150955 0.334014876106634 no 1126 0.299252417866119 1492 722793 SGTC_1364 1653-0028 37.6 µM 0.526503062578583 0.334030090679676 no 1127 0.299269362344102 1454 5718652 SGTC_1933 st074711 15.9 µM 0.52617911799508 0.334131118764403 no 1128 0.299381880709304 1400 17250958 SGTC_1128 3448-9350 235 µM 0.52615779535167 0.33413776904515 no 1129 0.299389287553199 1432 619386 SGTC_2125 5246583 200 µM 0.525888373690549 0.334221802965743 no 1130 0.299482883678632 1543 835267 SGTC_2571 chrysanthemic acid 100 µM 0.522195714362976 0.335374397204174 no 1131 0.300767034815492 1385 2743 An insecticide. SGTC_3002 9075603 71.4286 µM 0.519859528849799 0.336104395563397 no 1132 0.301580742478844 1431 20105405 SGTC_2903 5923464 63.88 µM 0.519373511438188 0.336256341420575 no 1133 0.30175014967223 1468 2876576 SGTC_715 0868-0130 184 µM 0.519174160712232 0.336318673092733 no 1134 0.301819648127265 1596 2876258 SGTC_426 0988-0037 14.6 µM 0.518104427611468 0.336653227010577 no 1135 0.302192705615237 1472 5383008 SGTC_760 0568-0725 82.9 µM 0.517692496613397 0.336782090965778 no 1136 0.302336417128212 1530 3916171 SGTC_688 0527-0193 473 µM 0.514312353832741 0.337840220225821 no 1137 0.303516812941799 1491 4007154 SGTC_2732 terfenadine 20 µM 0.513675522190269 0.338039719630853 no 1138 0.303739434190979 1465 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2872 9044037 25.97 µM 0.513304945451961 0.338155830657723 no 1139 0.303869012564199 1518 6465195 SGTC_2247 cerulenin 830 nM 0.513103050173145 0.338219096013734 no 1140 0.303939619009612 1521 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1036 k216-0215 33.5 µM 0.511283025934631 0.338789619884916 no 1141 0.304576444465682 1437 622330 SGTC_914 3820-6779 408 µM 0.510815531054126 0.338936225515309 no 1142 0.304740116424807 1421 2893481 SGTC_196 k015-0023 18.111 µM 0.510555310955809 0.339017840684165 no 1143 0.304831237532 1457 5211998 SGTC_2004 4023728 41.89 µM 0.510219349929946 0.339123222335674 no 1144 0.304948898696737 1494 360084 YDR527W RBA50 SGTC_3240 9133527 49.47 µM 0.507742111873432 0.339900651300927 no 1145 0.305817105654449 1451 17617455 SGTC_1106 tegaserod maleate 11.7 µM 0.506720843762933 0.340221353329556 no 1146 0.306175351664083 1506 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1189 1431-2119 7.28 µM 0.505511927123319 0.340601130798707 no 1147 0.306599661707322 1478 3107275 SGTC_2284 7945075 39.21 µM 0.505200445416805 0.340699008032992 no 1148 0.306709028755067 1573 1245402 SGTC_2680 butyl paraben 22.24 µM 0.503986604017913 0.341080537031869 no 1149 0.307135395307541 1496 7184 An antifungal and steroid mimetic. SGTC_1298 1079-1278 263 µM 0.503581597003886 0.341207873143768 no 1150 0.307277713684236 1488 2840950 SGTC_2204 7233102 200 µM 0.503030151029202 0.341381279427078 no 1151 0.307471536986149 1482 2172480 SGTC_1953 st076800 12.1 µM 0.502894148022301 0.341424051733239 no 1152 0.307519347855186 1427 297591 SGTC_791 1348-1292 225 µM 0.502650689223336 0.34150062346703 no 1153 0.307604942193285 1495 5437054 SGTC_1825 st052143 62.6 µM 0.501729325524125 0.341790466310235 no 1154 0.307928966616386 1528 674173 SGTC_193 1273-0060 1.558 µM 0.501558327409072 0.341844269212097 no 1155 0.307989119581403 1410 2847393 YHR072W ERG7 SGTC_1807 st050092 58.9 µM 0.500942291636789 0.342038125531449 no 1156 0.30820586870067 1457 5008496 SGTC_2282 7944268 200 µM 0.500043236689792 0.342321118058808 no 1157 0.308522316751209 1556 2970414 SGTC_959 1222-0044 107 µM 0.499897459859922 0.342367012093537 no 1158 0.308573640479309 1527 6083612 SGTC_276 colchicine 750 µM 0.497457741655592 0.343135438794491 no 1159 0.30943314787317 1518 2833 A microtubule depolymerizer. SGTC_899 1083-0020 478 µM 0.497066249082347 0.343258805910269 no 1160 0.309571167136011 1548 767123 SGTC_3252 9135871 49.47 µM 0.496463478588023 0.343448783568474 no 1161 0.309783724161642 1507 17682838 SGTC_3251 9135047 49.47 µM 0.494819924103082 0.343966990263662 no 1162 0.310363619466374 1568 17682963 SGTC_2946 9065502 71.43 µM 0.49288769666308 0.34457658944579 no 1163 0.311045970533493 1391 16489101 SGTC_210 3551-0445 56.827 µM 0.492785174468751 0.344608945508773 no 1164 0.311082193628373 1524 2865180 YOR207C RET1 SGTC_2862 9027634 71.43 µM 0.492053330546124 0.344839948879151 no 1165 0.31134082153132 1422 5012562 SGTC_1259 0671-0132 43 µM 0.490305442964434 0.345391895991379 no 1166 0.311958888006591 1485 X1259 SGTC_600 1495-0418 41.6 µM 0.488227555030767 0.346048478374106 no 1167 0.312694334447005 1506 5377768 SGTC_1293 1000-1278 195 µM 0.487899101558748 0.346152307334826 no 1168 0.312810655462899 1551 678847 SGTC_3293 9120939 62.045 µM 0.487017522352535 0.346431044616988 no 1169 0.313122956782861 1556 934087 SGTC_1891 st059073 26.2 µM 0.485238521859257 0.346993781294687 no 1170 0.313753579709992 1641 688754 SGTC_1740 st038286 13.222 µM 0.484343801776817 0.347276928461119 no 1171 0.314070947435292 1541 716786 SGTC_835 0312-0010 67.2 µM 0.476525519419888 0.34975474981029 no 1172 0.316850015545067 1493 1626196 SGTC_164 4100-3994 89.624 µM 0.475815041294826 0.349980238646182 no 1173 0.317103076538784 1634 4615967 SGTC_3278 9139605 49.47 µM 0.475288907302023 0.350147255150236 no 1174 0.31729053223623 1578 7958859 SGTC_1671 st016596 74.5 µM 0.475193714167339 0.350177476452489 no 1175 0.317324453502433 1509 2829167 SGTC_2938 9059746 27.26 µM 0.474802554134889 0.350301669373607 no 1176 0.317463856167258 1546 6471769 SGTC_1947 st076332 61.6 µM 0.470868212359795 0.351551707233186 no 1177 0.318867424649662 1541 24208416 SGTC_378 3970-0959 8.33 µM 0.470545405558038 0.351654342468733 no 1178 0.318982701083994 1534 6615653 SGTC_3257 9139206 32.98 µM 0.469466685123226 0.351997396074601 no 1179 0.319368046232697 1562 4910041 SGTC_2714 st079313 56.9 µM 0.469418690820839 0.352012661977148 no 1180 0.319385195501746 1518 2939799 SGTC_1691 st019933 84.6 µM 0.46913789415779 0.352101981826937 no 1181 0.319485537185027 1574 6176082 SGTC_3352 9151559 45.5865 µM 0.467077065620185 0.352757769306026 no 1182 0.32022237102036 1470 17159339 SGTC_1191 1487-1166 10.6 µM 0.464510801780647 0.353575005932967 no 1183 0.321140911172691 1612 3955771 SGTC_1456 k015-0012 13 µM 0.463486713660449 0.353901319502927 no 1184 0.321507768077071 1703 2989616 SGTC_1922 5578187 25 µM 0.463296019620303 0.353962093766687 no 1185 0.321576099241225 1637 1350412 SGTC_1611 st001856 99.4 µM 0.462595289602715 0.354185448639919 no 1186 0.321827242815597 1488 647478 SGTC_2457 5731572 11.68 µM 0.462057109393482 0.354357025485358 no 1187 0.322020183376217 1669 2865357 SGTC_2360 9040895 200 µM 0.460856515986286 0.354739892303752 no 1188 0.322450775564838 1508 4914414 SGTC_11 0438-0307 1.3 µM 0.459253223341015 0.355251407929995 no 1189 0.323026167156367 1628 4011476 SGTC_883 0850-0245 24.6 µM 0.459223427553068 0.355260916471643 no 1190 0.323036864319584 1612 6823229 YPR165W RHO1 SGTC_41 0478-0632 82.643 µM 0.458833974888484 0.355385208325752 no 1191 0.323176697496242 1611 3750424 SGTC_1151 3909-8316 15.3 µM 0.458817767766553 0.355390381080488 no 1192 0.323182517213315 1522 800431 SGTC_1435 4092-0789 56.7 µM 0.458014606298261 0.355646755894487 no 1193 0.323470973778407 1629 2248285 SGTC_1745 st081495 74 µM 0.456176447892707 0.356233754687067 no 1194 0.32413155010615 1568 13842402 YBL026W LSM2 SGTC_3088 9117578 49.47 µM 0.45538832591684 0.35648553859345 no 1195 0.32441494619427 1564 678341 SGTC_2739 tacrine 100.86 µM 0.451908611229144 0.357597961018376 no 1196 0.325667410310335 1551 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_661 1304-0007 33.6 µM 0.44989557102845 0.358242058979785 no 1197 0.326392870632403 1523 3117130 SGTC_2932 9016711 44.54 µM 0.44840995827311 0.358717658743681 no 1198 0.326928678095756 1688 7117328 SGTC_2196 6573537 42.6665 µM 0.447899410124618 0.358881154785956 no 1199 0.327112897064416 1644 2903087 SGTC_2655 perillic acid 100 µM 0.446410928984705 0.359357967945039 no 1200 0.327650219863729 1527 5702197 An apoptosis inducer. SGTC_354 2783-3500 4.88 µM 0.446368768760694 0.359371476550271 no 1201 0.327665444375352 1495 6740761 SGTC_33 0986-0033 35.816 µM 0.446334941609319 0.359382315273333 no 1202 0.327677659931732 1545 2848082 SGTC_3003 9075612 71.4286 µM 0.445182737065991 0.359751566279045 no 1203 0.328093850533024 1566 6501993 SGTC_2127 5253358 187.912 µM 0.444094046198465 0.360100583170699 no 1204 0.328487295417014 1505 20612 SGTC_3144 9087057 49.47 µM 0.442394700776904 0.36064559920701 no 1205 0.329101806517163 1703 17249618 SGTC_2463 5473429 200 µM 0.441911919395654 0.360800489115377 no 1206 0.329276472522349 1562 5399405 SGTC_2256 7954252 200 µM 0.44115736029727 0.361042618722299 no 1207 0.329549539917014 1539 2972920 SGTC_2158 5657123 3.6195 µM 0.438187615627206 0.36199611680167 no 1208 0.330625142666309 1575 2858827 SGTC_429 1112-0049 25.5 µM 0.437872993254248 0.362097183153169 no 1209 0.330739176967791 1511 2836170 SGTC_1303 1160-0052 261 µM 0.43661231127773 0.362502249246802 no 1210 0.331196266346804 1575 3562476 SGTC_126 0417-1624 672.48 µM 0.436147876105987 0.362651514406283 no 1211 0.331364721514831 1623 41912 YDL195W SEC31 SGTC_1666 st014829 29 µM 0.434856869554472 0.363066541552012 no 1212 0.331833161370819 1545 3858230 SGTC_530 4358-1714 28 µM 0.434700243398028 0.363116903995373 no 1213 0.33189001085041 1630 1564641 SGTC_2921 7974240 10.71 µM 0.434544037008644 0.363167133821938 no 1214 0.331946711825351 1625 2979074 YDR527W RBA50 SGTC_2069 5228469 200 µM 0.434186605839551 0.363282078470051 no 1215 0.33207646936843 1535 2835210 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.42863356082666 0.365069432435309 no 1216 0.334094958989415 1643 77254 SGTC_3039 9090270 49.47 µM 0.427980530503165 0.365279816409379 no 1217 0.334332647623025 1681 17173750 SGTC_1839 st053978 48 µM 0.42733814230733 0.365486811419429 no 1218 0.33456652758158 1613 3788398 SGTC_1006 4099-6547 255 µM 0.424471613722004 0.366410961932335 no 1219 0.335610951489889 1620 3146833 SGTC_1906 st060206 94.7 µM 0.424140569460408 0.366517738521152 no 1220 0.335731649992318 1692 5133468 SGTC_172 1112-0046 2.638 µM 0.423229593057239 0.366811622494829 no 1221 0.336063878799296 1600 2802135 YIL048W NEO1 SGTC_1730 st033808 45.1 µM 0.422037344223157 0.367196363826507 no 1222 0.336498879861531 1591 1045166 SGTC_272 doxorubicin 8.13 µM 0.418943615131188 0.36819533832933 no 1223 0.337628670348667 1589 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_487 nimodipine 119 µM 0.417684524331843 0.368602158299705 no 1224 0.338088894305409 1661 4497 L-type voltage-gated calcium channels inhibitor SGTC_552 k242-0005 476 µM 0.41707807323903 0.368798158967027 no 1225 0.338310651256361 1617 4088318 SGTC_2361 9034121 116 µM 0.417025469615164 0.368815161692372 no 1226 0.338329889119754 1586 6496917 SGTC_67 0335-0847 266 µM 0.416203162069363 0.369080984142637 no 1227 0.338630673050167 1827 4552207 YOR254C SEC63 SGTC_711 k292-0785 179 µM 0.415266670589098 0.369383794420341 no 1228 0.338973348606859 1569 4146315 SGTC_2016 5121758 140 µM 0.412349423539111 0.370327591762355 no 1229 0.340041663994244 1562 2795203 SGTC_1360 1598-0022 39.8 µM 0.412094399702453 0.37041013512183 no 1230 0.340135116657262 1699 761525 SGTC_175 3793-3120 23.7 µM 0.410730219676575 0.370851779415956 no 1231 0.340635182698199 1586 5322297 SGTC_1808 st050063 61.5 µM 0.409183115215639 0.37135285023342 no 1232 0.341202642278325 1690 4011993 SGTC_2869 9037858 32.47 µM 0.408893862142516 0.371446556740874 no 1233 0.341308776784062 1551 27187042 SGTC_3061 glucosamine 200 µM 0.408231869341584 0.371661044782285 no 1234 0.341551726459542 1705 91431 and experimental redox chemotherapeutic SGTC_1126 isoteolin 1.0172 µM 0.407347778912898 0.371947555386141 no 1235 0.341876287791122 1537 133323 SGTC_1773 st048542 73.5835 µM 0.406905364559893 0.372090956952238 no 1236 0.342038747874439 1528 3237138 SGTC_2827 7993847 71.43 µM 0.401252493195154 0.373924800482924 no 1237 0.344117118190189 1647 2985692 SGTC_1453 4237-0541 195 µM 0.40083492404328 0.374060377594925 no 1238 0.344270832169201 1751 739892 SGTC_2024 5144227 134 µM 0.400744102441495 0.374089867781239 no 1239 0.344304268481767 1687 3475211 SGTC_874 0599-0792 117 µM 0.400549409862381 0.374153087828059 no 1240 0.344375949383678 1767 765305 SGTC_1254 0550-0035 264 µM 0.400439259211574 0.374188857148229 no 1241 0.344416506554015 1703 15121435 SGTC_1985 st071382 65.5 µM 0.398058112038368 0.374962353514985 no 1242 0.345293675108068 1632 6123237 SGTC_271 rotenone 740 µM 0.394983834236466 0.375961751645163 no 1243 0.346427409217427 1682 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_481 bay k-8644 50 µM 0.394570080354368 0.376096320068212 no 1244 0.346580099007468 1587 2303 A calcium channel antagonist. SGTC_1215 3852-0577 11.2 µM 0.394251801936216 0.376199846510176 no 1245 0.346697571945977 1737 2884876 SGTC_702 1488-0190 94 µM 0.394033131425139 0.376270978644916 no 1246 0.346778289284546 1758 949357 SGTC_1226 3909-7979 35.4 µM 0.392342399567091 0.376821104732974 no 1247 0.347402619751655 1746 6615510 SGTC_1154 4088-0362 150 µM 0.392295281509087 0.376836439476929 no 1248 0.34742002480794 1601 6618304 SGTC_2018 5133068 143 µM 0.392083414046205 0.37690539491685 no 1249 0.34749829103066 1619 785362 SGTC_1662 st014054 52 µM 0.391685472530333 0.377034921557069 no 1250 0.347645312672921 1628 2838777 SGTC_2859 9028643 45.46 µM 0.390592898085789 0.377390616530519 no 1251 0.348049087982821 1706 17151580 SGTC_960 1222-0186 7.7 µM 0.390440312220876 0.377440300172861 no 1252 0.348105491828542 1703 3126296 SGTC_756 0508-1999 28.3 µM 0.390429792334741 0.37744372563869 no 1253 0.348109380661436 1557 6753853 SGTC_728 3030-5151 22.5 µM 0.390390801444113 0.377456421864331 no 1254 0.34812379436531 1671 3125388 SGTC_3275 9138069 49.47 µM 0.389603181914343 0.377712915113718 no 1255 0.348414999445285 1695 17617007 SGTC_822 1487-0950 154 µM 0.387622301524009 0.378358239416758 no 1256 0.349147781308391 1735 1958375 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.386079690501485 0.378861021051076 no 1257 0.349718825308583 1577 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_3079 9117512 49.47 µM 0.3846590392982 0.379324233858016 no 1258 0.350245023147073 1710 7185044 SGTC_1158 4092-0494 91.8 µM 0.383632831175166 0.379658943710403 no 1259 0.350625301401684 1735 1148199 SGTC_414 piperonyl butoxide 100 µM 0.382162817401227 0.380138563077953 no 1260 0.35117029991554 1607 5794 A potent inhibitor of cytochrome P450. SGTC_2264 7948757 110.76 µM 0.377907963233765 0.381527825247184 no 1261 0.352749483288219 1610 2971411 SGTC_2235 salicylic acid 500 µM 0.376208505035257 0.382083147203142 no 1262 0.353380946497025 1705 338 A COX inhibitor and kinase inhibitor. SGTC_1802 st050112 57.9 µM 0.375036315425128 0.382466318197246 no 1263 0.35381672934341 1656 4662563 SGTC_3116 9124943 49.47 µM 0.374088658625353 0.382776176985976 no 1264 0.354169178127184 1578 41905195 YPL160W CDC60 SGTC_3157 9099274 49.47 µM 0.373448801861595 0.382985435732228 no 1265 0.354407221825918 1786 17217662 SGTC_2506 ethyl hematommate 54.16 µM 0.371581806126932 0.383596213009648 no 1266 0.355102118646398 1587 3940691 An allergen. SGTC_1491 4138-0063 26.5 µM 0.3711334079924 0.383742947116144 no 1267 0.355269084572173 1761 23883227 SGTC_1063 disulfiram 1.84 µM 0.370117368778856 0.384075498128424 no 1268 0.355647520607656 1668 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1051 3253-3903 78 µM 0.367903789210886 0.384800301008503 no 1269 0.356472487359667 1637 5509239 SGTC_611 3453-1652 23.7 µM 0.3658428991148 0.385475470201441 no 1270 0.357241153357668 1762 1560575 SGTC_1027 k015-0025 8.67 µM 0.365774857731258 0.385497767203779 no 1271 0.35726654117688 1628 3598955 SGTC_1461 k072-0203 53.8 µM 0.364627527356618 0.385873801621983 no 1272 0.357694731840908 1642 5418714 SGTC_3053 9095903 49.47 µM 0.364287347417846 0.385985315306723 no 1273 0.357821723519331 1733 17174018 SGTC_108 0509-0257 621.132 µM 0.363664173331676 0.386189621151389 no 1274 0.358054399812408 1753 536624 SGTC_93 0109-0045 59.227 µM 0.359965093523194 0.387403001831577 no 1275 0.359436618765888 1730 88733 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.359615757661775 0.387517648854996 no 1276 0.359567249001122 1664 6312947 SGTC_1071 trifluoperazine 6.31 µM 0.358744123158553 0.387803749559816 no 1277 0.359893258498104 1773 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_3112 9123419 49.47 µM 0.357154262969457 0.388325753672288 no 1278 0.36048816182856 1717 17015854 SGTC_3031 9088762 49.47 µM 0.356373212243679 0.388582272644796 no 1279 0.360780543885111 1635 205253 SGTC_580 1123-0028 41 µM 0.355744873800083 0.388788671897877 no 1280 0.361015818022324 1717 1677248 YPR107C YTH1 SGTC_2973 9094665 17.96 µM 0.355669836349955 0.388813322614593 no 1281 0.361043918453746 1813 25237061 YIL048W NEO1 SGTC_1309 pyrazolanthrone 13.4 µM 0.353675792634825 0.38946855399618 no 1282 0.361790933100897 1784 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2719 novobiocin 32.65 µM 0.353043018306152 0.389676545821455 no 1283 0.362028095198927 1802 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2864 9034755 47.6 µM 0.352151984751186 0.389969480573352 no 1284 0.362362141973045 1758 4930451 SGTC_645 0845-0943 5.41 µM 0.351054139906516 0.390330492201 no 1285 0.362773866034381 1700 1885106 SGTC_3059 1327-0034 3 µM 0.35066569464702 0.390458249911434 no 1286 0.362919582450595 1658 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1033 k072-0102 21.3 µM 0.350599384422973 0.390480060196076 no 1287 0.362944459209042 1804 5965931 SGTC_2935 9038016 29.96 µM 0.35035761397145 0.390559584522381 no 1288 0.363035166034194 1806 6463195 SGTC_443 clozapine 122 µM 0.350025944464548 0.390668686336032 no 1289 0.363159613458706 1798 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1716 st033144 30.6155 µM 0.349265844205617 0.390918751776248 no 1290 0.363444869071179 1836 674617 SGTC_1826 st055655 41.6 µM 0.348199584372721 0.391269616682192 no 1291 0.363845149948058 1711 676168 SGTC_3102 9121669 49.47 µM 0.347691398012903 0.391436872333052 no 1292 0.364035978741234 1754 41905072 SGTC_1935 st074532 41.6 µM 0.347290667052459 0.391568776133459 no 1293 0.364186480795336 1864 2829742 SGTC_2396 5342950 42.78 µM 0.346290328916639 0.391898099807953 no 1294 0.364562267971769 1686 1886677 SGTC_1810 st050138 53 µM 0.345958371995692 0.392007401258417 no 1295 0.364686999747057 1806 3444541 SGTC_124 0136-0217 7.121 µM 0.34530614590487 0.39222218062004 no 1296 0.364932113374585 1848 3976905 SGTC_96 0929-0093 37.281 µM 0.344733028597995 0.39241093640867 no 1297 0.365147542639098 1670 6991579 SGTC_2533 agelasine 13.65 µM 0.344310729299578 0.392550036591325 no 1298 0.365306308111712 1873 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1721 st082152 9.2685 µM 0.340368917369506 0.393849080657747 no 1299 0.366789361579436 1675 5296051 SGTC_1946 st076057 65.1 µM 0.339558384846709 0.394116342749874 no 1300 0.367094560959374 1693 953009 SGTC_1821 st053465 65.6 µM 0.336779407420589 0.395033050678959 no 1301 0.368141598836827 1702 675086 SGTC_788 1182-0090 188 µM 0.336614978197271 0.395087309605338 no 1302 0.368203581777095 1868 5715185 SGTC_1506 4226-2149 212 µM 0.336217541995261 0.395218465383545 no 1303 0.368353412768373 1767 991114 SGTC_1331 1472-0049 76.2 µM 0.335738224952525 0.39537665800722 no 1304 0.368534138963586 1681 24051409 SGTC_2937 9044753 11.33 µM 0.332701059814425 0.396379436293636 no 1305 0.369679974733383 1685 6465530 YGL099W LSG1 SGTC_3155 9099265 49.47 µM 0.332535806806668 0.396434017475766 no 1306 0.369742353293877 1764 25236499 SGTC_1652 st011932 78 µM 0.332225435649957 0.396536535011201 no 1307 0.369859519311792 1806 1551076 SGTC_2992 9074591 71.4286 µM 0.331740375688084 0.396696767674842 no 1308 0.370042655055958 1753 17741321 SGTC_1640 st009078 66.4 µM 0.331539138988965 0.396763248479551 no 1309 0.370118641185968 1810 690618 SGTC_1647 st011722 22.4 µM 0.330903143494362 0.396973376457178 no 1310 0.370358823723894 1755 2854783 SGTC_310 1273-0058 1.06 µM 0.330693854891404 0.397042530332682 no 1311 0.370437872241942 1747 2734232 SGTC_3285 9112818 20.8695 µM 0.330015935768083 0.397266552967303 no 1312 0.370693960531214 1743 17017947 YPR165W RHO1 SGTC_91 0417-1751 58.384 µM 0.329256426351616 0.397517577885146 no 1313 0.370980938129983 1748 6795624 SGTC_2376 9072922 81.32 µM 0.328754756101655 0.397683407847686 no 1314 0.371170531600151 1761 17087968 SGTC_1508 1080-0625 72.9 µM 0.328022694610569 0.397925428119543 no 1315 0.37144725166087 1747 767111 SGTC_1025 k007-0731 70 µM 0.326396337139502 0.398463244006258 no 1316 0.372062254231445 1698 6256118 SGTC_4 0960-0234 25.671 µM 0.3263278031762 0.398485911565747 no 1317 0.372088177340262 1731 6821112 SGTC_336 4111-0029 111 µM 0.325254569074376 0.398840927611142 no 1318 0.372494205846399 1706 3131175 SGTC_3296 9122258 64.045 µM 0.323741363861511 0.399341624242242 no 1319 0.373066926025607 1750 4730474 SGTC_1276 0871-0068 94.2 µM 0.323551360431447 0.399404505212954 no 1320 0.37313885866424 1818 3414906 SGTC_3178 9107506 49.47 µM 0.323309094971463 0.399484685904769 no 1321 0.373230583389552 1779 8897194 SGTC_2038 4100038 30.985 µM 0.323272201887263 0.399496896490427 no 1322 0.373244552201946 1762 3596803 SGTC_1812 st052057 4.327 µM 0.321727779530233 0.400008145430822 no 1323 0.373829465423041 1699 3645418 SGTC_203 k066-0004 30.888 µM 0.320627660801664 0.400372421487778 no 1324 0.374246286578341 1907 6795412 SGTC_615 k087-0205 167 µM 0.318189726483809 0.401179989277341 no 1325 0.375170512602215 1679 9642773 SGTC_1304 1165-0502 251 µM 0.31702425687279 0.401566201502139 no 1326 0.375612598277902 1792 767425 SGTC_2893 9048488 25.97 µM 0.315787300633469 0.401976208094487 no 1327 0.376081978945076 1673 6467338 SGTC_2593 nobiletin 86.24 µM 0.31343134940229 0.402757419471234 no 1328 0.376976484926162 1698 72344 An anti-infammatory. SGTC_2486 5283202 22.39 µM 0.311840607232475 0.40328511455074 no 1329 0.377580830818813 1692 1377751 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.310133467853074 0.403851617892874 no 1330 0.378229731232716 1908 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_57 miconazole 162.5 nM 0.310112286752483 0.403858647975838 no 1331 0.37823778453855 1691 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_3310 9130229 44.1445 µM 0.307659637460701 0.404672900476596 no 1332 0.379170667765343 1858 7761258 SGTC_3220 9131269 49.47 µM 0.30762447464771 0.404684577153715 no 1333 0.379184047332771 1770 17722206 SGTC_3309 9129340 25.759 µM 0.306150488095178 0.405174126885142 no 1334 0.379745034130215 1802 17158987 SGTC_1873 rapamycin 2 nM 0.305676519660622 0.405331575848729 no 1335 0.379925476356057 1736 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2236 dapsone 200 µM 0.304970024378822 0.405566297020632 no 1336 0.380194491270354 1869 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_1503 4585-0012 61.3 µM 0.304646110235621 0.405673923405247 no 1337 0.380317848687793 1846 2922052 SGTC_2334 9017922 200 µM 0.303694777773168 0.405990062174047 no 1338 0.38068021847317 1893 3163164 SGTC_1372 2752-0194 270 µM 0.302482330843871 0.406393061137974 no 1339 0.381142200472344 1739 823334 SGTC_5 0352-0601 109.883 µM 0.298165520578648 0.407828705723141 no 1340 0.382788418076309 1798 762456 SGTC_2179 6298986 200 µM 0.298115069402124 0.40784549166516 no 1341 0.382807670245046 1921 738374 SGTC_143 4032-1194 15.74 µM 0.29721280929938 0.408145717081348 no 1342 0.383152021548149 1751 1806963 SGTC_1907 st060210 83.7 µM 0.297110573032182 0.408179739419309 no 1343 0.383191046272806 1869 688793 SGTC_2952 9073731 13.78 µM 0.296153480006184 0.408498275808924 no 1344 0.383556436809449 1736 16457353 SGTC_954 1189-0853 2.85 µM 0.295463095031982 0.408728084897341 no 1345 0.383820070222918 1830 2828194 SGTC_934 2950-0684 338 µM 0.293278049361065 0.409455629577896 no 1346 0.384654815213365 1896 1121253 SGTC_3068 9116768 49.47 µM 0.288908933544087 0.410911327260682 no 1347 0.38632553356873 1782 41904888 SGTC_1398 3558-0053 112 µM 0.288867444929995 0.41092515631235 no 1348 0.386341408676035 1788 4532369 SGTC_735 3076-0345 636 µM 0.286791602880782 0.411617220327505 no 1349 0.387135946460118 1901 2888990 SGTC_2816 7982706 58.44 µM 0.285769024622145 0.411958238473884 no 1350 0.387527516984976 1775 2981853 SGTC_1363 1636-0063 10.4 µM 0.285172045895053 0.412157354807436 no 1351 0.387756167846884 1799 6072185 SGTC_3303 9125618 40.5795 µM 0.284940110067889 0.412234720805039 no 1352 0.387845012884989 1874 22695467 SGTC_315 k915-0449 187 µM 0.284172048914342 0.412490944527819 no 1353 0.388139267291083 1860 20970215 YNL149C PGA2 SGTC_2391 6285546 200 µM 0.28236674487428 0.413093337157329 no 1354 0.388831155826126 1761 846083 SGTC_2619 obliquin 87.91 µM 0.282227287685477 0.413139879671823 no 1355 0.388884617944066 1886 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1065 prochlorperazine maleate 2.48 µM 0.280611843767408 0.413679107577189 no 1356 0.389504065443276 1803 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1404 3909-7820 48.3 µM 0.27803455834225 0.414539730556244 no 1357 0.390492915243277 1917 23741373 SGTC_696 1560-0013 611 µM 0.278032848945746 0.414540301505073 no 1358 0.390493571338386 1868 1650269 SGTC_970 1315-0089 19.5 µM 0.276948353218892 0.414902566019287 no 1359 0.39090988180454 1763 6811083 YLR033W RSC58 SGTC_2032 5185112 25.99 µM 0.276175953848435 0.415160622141404 no 1360 0.391206462655849 1866 5718189 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.275562369312897 0.41536564483785 no 1361 0.391442107930801 1792 688803 SGTC_439 amiodarone 34.4 µM 0.273013070904839 0.416217711757437 no 1362 0.392421584000434 1876 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_184 1494-0393 24.714 µM 0.27256225578383 0.416368431435177 no 1363 0.392594864597433 1763 3090647 SGTC_1997 st073024 93.8 µM 0.269114543824711 0.417521499800649 no 1364 0.393920769403931 1949 686268 SGTC_334 1502-1024 68.5 µM 0.268230239221664 0.417817365364486 no 1365 0.394261050009066 1860 3296216 SGTC_710 3448-4187 58 µM 0.268067049936506 0.417871969389569 no 1366 0.394323854111936 1827 3946412 SGTC_69 0096-0274 206.684 µM 0.267969523478368 0.417904603030448 no 1367 0.394361388903284 1909 6741392 SGTC_2886 9058944 51.95 µM 0.267075565936626 0.418203759340932 no 1368 0.394705490021163 1827 4949929 SGTC_2919 7978188 46.38 µM 0.267044227336882 0.418214247432259 no 1369 0.394717554331426 1967 2980291 SGTC_3271 9137798 49.47 µM 0.263433171292381 0.419423147378856 no 1370 0.396108363120484 1953 6498326 SGTC_3331 9141060 1.957 µM 0.263315021389303 0.419462714214127 no 1371 0.396153891355908 1789 4906567 YPR165W RHO1 SGTC_2978 9011784 42.97 µM 0.262660481096192 0.419681925816987 no 1372 0.396406139504133 2000 2994934 SGTC_507 nimesulide 162 µM 0.260785063289432 0.42031015840026 no 1373 0.397129131874525 1965 4495 A COX2 inhibitor. SGTC_1612 st002233 45.4 µM 0.259777826662161 0.420647649201119 no 1374 0.397517577833967 1897 1035021 SGTC_1732 st034308 51.822 µM 0.25858732051821 0.42104662260039 no 1375 0.397976833671584 1783 830119 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.257637769091239 0.421364903189873 no 1376 0.398343238964997 1774 23665772 A membrane-active detergent. SGTC_2962 9082311 13.18 µM 0.256277204901642 0.421821040859562 no 1377 0.398868398744234 1785 16459453 SGTC_2443 5493264 126.67 µM 0.255589317096815 0.422051699523161 no 1378 0.399133984100511 1937 5340055 SGTC_2094 5332512 191.667 µM 0.251546964235235 0.423407696258953 no 1379 0.400695628459928 1942 755774 SGTC_679 0422-0091 41.4 µM 0.251334850918082 0.423478874321321 no 1380 0.400777616291991 1782 627384 YHR062C RPP1 SGTC_3353 9151644 39.2805 µM 0.248774068892815 0.424338382640659 no 1381 0.40176777531906 1867 4909158 SGTC_967 1306-0166 352 µM 0.248634373622221 0.424385280757597 no 1382 0.4018218084818 1991 4437607 SGTC_1197 1601-0112 267 µM 0.247210930841486 0.4248632160239 no 1383 0.402372493106622 1808 7350313 SGTC_2874 9043904 71.43 µM 0.246912220725031 0.424963525004281 no 1384 0.402488079164817 1848 4463428 SGTC_2765 myclobutanil 7.74 µM 0.243865757625147 0.425986825315501 no 1385 0.40366739504018 1874 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3167 9103034 49.47 µM 0.240231488563238 0.427208220032196 no 1386 0.40507540198218 1904 5127859 SGTC_1981 st071826 47 µM 0.239859218512273 0.427333371097111 no 1387 0.40521969846766 1880 11838600 SGTC_2238 6671620 73.2395 µM 0.235949911734811 0.428648054993825 no 1388 0.406735768737854 1835 729941 SGTC_2427 5545055 42.75 µM 0.235242154451577 0.428886155990272 no 1389 0.407010394667626 1898 5372858 SGTC_1460 k062-0059 9.15 µM 0.234587812521073 0.429106310225749 no 1390 0.4072643349091 1823 1373085 SGTC_1964 st076914 61 µM 0.23152029132615 0.430138674874523 no 1391 0.408455311705284 1964 24208661 SGTC_1886 st057356 49.9 µM 0.230479508249647 0.43048905606408 no 1392 0.408859592476244 1824 24207747 SGTC_3280 9140961 49.47 µM 0.230000702058574 0.430650265287488 no 1393 0.409045612088192 1853 4901226 SGTC_1086 cerivastatin 2.18 µM 0.229505442900939 0.430817026218951 no 1394 0.409238045348958 2002 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_523 1934-0222 13.7 µM 0.228567221687499 0.431132972687935 no 1395 0.409602651731508 1838 1361595 SGTC_221 trifluoperazine 10.304 µM 0.228046289551801 0.431308415890888 no 1396 0.409805127302914 1920 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_260 nsc-65238 3.989 µM 0.22757712695169 0.431466435385207 no 1397 0.409987501713432 1967 3246252 SGTC_455 paf C-16 10 µM 0.22709865133986 0.43162760290907 no 1398 0.41017351636481 1896 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_1381 2324-0066 62.1 µM 0.226430548474696 0.431852662641442 no 1399 0.410433285295752 1915 10885928 SGTC_1921 5740136 50 µM 0.22555221512 0.432148575080121 no 1400 0.410774854935243 2049 1774243 SGTC_136 0097-0015 404.482 µM 0.225497016306972 0.432167172954718 no 1401 0.410796323123865 2040 4861337 SGTC_561 1550-0330 72.9 µM 0.224923687297894 0.43236035086309 no 1402 0.411019320797956 1868 6812934 SGTC_3023 9089636 49.47 µM 0.223104270208992 0.432973493494481 no 1403 0.411727177484025 2072 17249241 SGTC_2570 licareol 100 µM 0.221577167393109 0.433488251013193 no 1404 0.412321529231585 1878 443158 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.218023296039845 0.434686629358751 no 1405 0.413705480196212 1897 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_879 0831-1030 162 µM 0.217916542747119 0.434722636299327 no 1406 0.413747068814055 1872 1549252 SGTC_2139 5578692 56.4705 µM 0.21776730482128 0.43477297383799 no 1407 0.413805210085533 2054 650991 YMR113W FOL3 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.21733970315327 0.434917208547248 no 1408 0.413971808927045 1888 6708514 SGTC_415 dibenzyl ketone 100 µM 0.216442800511054 0.435219771711107 no 1409 0.414321303434584 2024 7593 SGTC_2957 9076800 11.52 µM 0.215264620390002 0.435617279268903 no 1410 0.414780505919382 1881 16459615 SGTC_3204 9114183 49.47 µM 0.214858112579702 0.435754446527003 no 1411 0.414938971736769 1853 17027248 SGTC_2522 biochanin a 4.94 µM 0.214805400039548 0.43577223379868 no 1412 0.414959521275731 1976 5280373 A possible chelator. SGTC_2986 9022445 71.43 µM 0.214467709811969 0.435886186763113 no 1413 0.415091172478987 2035 6459286 SGTC_147 4466-0538 29.23 µM 0.211563036559805 0.436866582397164 no 1414 0.416223974539408 1938 6742687 YHR072W ERG7 SGTC_2850 9015429 58.44 µM 0.211082604352172 0.437028777126736 no 1415 0.416411407065858 1903 6457570 SGTC_2954 9074818 52.69 µM 0.211050824528653 0.437039506422698 no 1416 0.416423806098981 1966 16648742 SGTC_3173 9105693 49.47 µM 0.210449642321189 0.437242482338977 no 1417 0.416658375543886 1990 17096658 SGTC_571 k831-0106 44.2 µM 0.204292762258435 0.439322158706283 no 1418 0.419062362794859 2068 4783639 SGTC_676 falcarinol 140 µM 0.202855823974996 0.43980777230394 no 1419 0.419623861840702 2067 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_152 4469-0003 551.229 µM 0.202073286184473 0.440072269257481 no 1420 0.419929715793671 2091 697280 SGTC_44 0929-0055 61.211 µM 0.201971419128496 0.440106702185695 no 1421 0.419969533971655 1924 1379590 SGTC_2856 9022925 19.48 µM 0.201665619628682 0.440210070730114 no 1422 0.420089070949735 1962 4944862 SGTC_1978 st071761 42 µM 0.201271458583024 0.440343313889919 no 1423 0.420243159316124 1890 5147680 SGTC_1863 st057641 20.1 µM 0.200918194155341 0.440462737998482 no 1424 0.420381270461274 2106 3921635 SGTC_2944 9067346 25.62 µM 0.200749474157711 0.440519777170999 no 1425 0.420447236158856 1962 6473075 SGTC_256 clotrimazole 625 nM 0.200320476725218 0.440664813896477 no 1426 0.420614974497188 2028 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2326 6164455 177.58 µM 0.198057463407164 0.441430031453506 no 1427 0.421500052402493 1924 2888790 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.197352322635994 0.441668513269872 no 1428 0.421775918416907 1979 2724278 An inhibitor of dopamine biosynthesis. SGTC_1107 amlodipine 47 µM 0.196787737034672 0.441859473937341 no 1429 0.421996823952361 1980 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2730 imipramine 71.33 µM 0.196592710990671 0.441925441042483 no 1430 0.422073137543631 2068 3696 A tricyclic antidepressant. SGTC_2794 7785382 27.27 µM 0.196533863552749 0.441945346367708 no 1431 0.422096165090765 2107 2205081 SGTC_737 1950-0117 57.9 µM 0.193116526764115 0.44310152077569 no 1432 0.423433854897481 2089 5393513 SGTC_1436 4092-1007 8.32 µM 0.192886546794184 0.443179346528423 no 1433 0.423523910644144 1985 2881121 SGTC_718 1130-0073 349 µM 0.192820882789587 0.443201567781586 no 1434 0.423549624142685 2011 6740020 SGTC_3188 9110789 49.47 µM 0.191635749427707 0.443602657549578 no 1435 0.424013768740354 2062 849217 SGTC_2131 toluylene red 5.2905 µM 0.187145101144277 0.445122967789309 no 1436 0.425773433591201 1917 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_3103 9120822 49.47 µM 0.185208964721461 0.44577869776164 no 1437 0.426532568953091 2068 17141819 SGTC_2796 7949634 45.45 µM 0.18474066248084 0.445937324539732 no 1438 0.426716225517894 1962 2971588 SGTC_400 oxethazaine 37.5 µM 0.184065906040114 0.446165898213162 no 1439 0.426980876248791 1976 4621 A local anesthetic. SGTC_2063 5246145 200 µM 0.1827438104224 0.446613809764637 no 1440 0.427499519397156 2025 711240 SGTC_3338 9144300 39.5675 µM 0.182572298559325 0.446671921113798 no 1441 0.427566810761989 2025 4901274 SGTC_2713 st079149 53.4 µM 0.18168799442277 0.446971557639577 no 1442 0.427913794109706 1989 3103253 SGTC_1558 st069300 45.6 µM 0.180708839459982 0.447303368614266 no 1443 0.428298060067711 2089 24208000 SGTC_503 tyrphostin 8 294 µM 0.179085910889395 0.447853419390277 no 1444 0.42893512232352 2090 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1680 diphenhydramine 100 µM 0.176658002551712 0.448676484713225 no 1445 0.429888515524815 1950 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_3344 9148862 3.898 µM 0.175256990601983 0.449151531062147 no 1446 0.430438852593669 2070 4905352 SGTC_2084 5306078 60.6385 µM 0.175072869231123 0.449213967216584 no 1447 0.430511188110678 2030 679340 SGTC_355 1311-2252 105 µM 0.174538038520557 0.449395337172661 no 1448 0.430721319552817 1955 5338538 SGTC_2417 cerulenin 830 nM 0.174461155173402 0.449421410459729 no 1449 0.43075152812445 2140 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_3292 9120825 59.784 µM 0.174127923795004 0.449534421036051 no 1450 0.430882464202171 2131 24824900 SGTC_912 3474-0017 2.18 µM 0.174026261916444 0.449568898999174 no 1451 0.43092241155628 2056 3360550 SGTC_1334 1486-0610 236 µM 0.173309025477067 0.449812155863734 no 1452 0.43120426486931 2044 3742339 SGTC_973 1325-0077 65.9 µM 0.172742698326522 0.450004243883825 no 1453 0.431426839929772 2065 2835149 SGTC_1520 flindersine 88 µM 0.172629946081915 0.450042488824207 no 1454 0.431471155853713 2101 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_838 0109-0203 71.4 µM 0.171226321087286 0.450518629419164 no 1455 0.432022905937304 2004 759422 SGTC_2277 7947813 106.88 µM 0.170893697268753 0.450631473228325 no 1456 0.432153676306255 2089 1246798 SGTC_114 0364-0001 490.298 µM 0.170473483714577 0.450774037870027 no 1457 0.432318893025162 1954 4003655 SGTC_2239 6685329 187.64 µM 0.170283853826985 0.450838375136376 no 1458 0.432393454297312 1966 805680 SGTC_1499 4480-0877 67.3 µM 0.168373216099124 0.451486684447869 no 1459 0.433144838866554 2098 2861909 SGTC_741 4582-0002 126 µM 0.166525491966127 0.452113769304637 no 1460 0.433871711776466 1975 2912688 SGTC_2071 5230951 39.92 µM 0.166360309785624 0.452169835053393 no 1461 0.433936703428742 2098 1799272 SGTC_2436 5633522 8.09 µM 0.166143510052522 0.452243422158233 no 1462 0.434022006943183 2134 5724242 SGTC_623 k072-0108 16.9 µM 0.165207147239988 0.452561265294023 no 1463 0.434390469941736 2026 5382803 SGTC_2215 7188065 200 µM 0.164309886016601 0.452865864139574 no 1464 0.4347435997748 2107 940217 SGTC_1402 3909-7673 35.9 µM 0.163877889721469 0.453012526510629 no 1465 0.434913636606278 2083 5328014 SGTC_3235 9132602 49.47 µM 0.162297852935495 0.453549002088931 no 1466 0.435535652687628 2044 4912240 SGTC_516 3992-2719 87.3 µM 0.162158145606404 0.453596441515006 no 1467 0.435590659235595 1953 5350887 YDR037W KRS1 SGTC_2695 st077686 51.995 µM 0.161947983169244 0.453667806129035 no 1468 0.435673408209079 1985 2876092 SGTC_1527 coumarin 137 µM 0.161682720782745 0.453757883104287 no 1469 0.435777856156211 2065 323 A hepatotoxic, DNA x-linker. SGTC_2652 actinonin 100 µM 0.161142036334546 0.453941494406747 no 1470 0.435990766320019 2096 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1345 1488-0192 31.4 µM 0.161089465235484 0.453959347578342 no 1471 0.43601146870366 2110 658348 SGTC_3130 9127414 49.47 µM 0.160444608003393 0.454178348976172 no 1472 0.436265426317026 2175 1494646 SGTC_1603 st002045 67.8 µM 0.160104484151551 0.454293864809604 no 1473 0.436399384451046 2145 5887985 SGTC_1574 spiramycin 23.7 µM 0.15927229029481 0.454576518038209 no 1474 0.436727175599395 2097 6419898 An antibiotic and protein synthesis inhibitor. SGTC_708 3448-5400 146 µM 0.158057327488612 0.454989219356143 no 1475 0.437205812794616 2136 3462195 SGTC_2345 9052315 157.45 µM 0.157857536030143 0.455057089634876 no 1476 0.437284529886139 1997 6469265 SGTC_3096 9117468 49.47 µM 0.156826426792239 0.455407384037937 no 1477 0.437690822492682 2128 41316311 SGTC_609 0986-0026 86.3 µM 0.156533691794458 0.455506839997933 no 1478 0.437806182172514 2046 2848610 SGTC_667 1498-1044 59 µM 0.155662650432364 0.455802790521305 no 1479 0.43814946942937 2024 6739982 SGTC_3201 9113999 49.47 µM 0.155565741012791 0.45583571859783 no 1480 0.438187665410377 2070 16649224 SGTC_2064 5220758 200 µM 0.155144182733703 0.455978960040576 no 1481 0.43835382553196 2040 788518 SGTC_906 1165-0455 526 µM 0.154661846936978 0.456142860115994 no 1482 0.438543954863046 2074 3252859 SGTC_2073 5212005 126 µM 0.154467444796889 0.456208921030748 no 1483 0.438620589200891 2184 691789 SGTC_1604 st002052 72.4 µM 0.154453231845654 0.456213750863357 no 1484 0.438626192110727 2041 6254834 YHR062C RPP1 SGTC_2117 5521686 200 µM 0.153902875025331 0.456400777603582 no 1485 0.438843158586155 2020 803312 SGTC_1135 dihydrocapsaicin 536.708 nM 0.153901886466457 0.456401113552419 no 1486 0.438843548321028 1974 107982 A Capsaicinoid. SGTC_1673 st016611 27.3 µM 0.153415080774775 0.45656655189767 no 1487 0.439035476463773 2105 5226799 SGTC_726 3448-4391 34.2 µM 0.152736782942165 0.456797080384289 no 1488 0.439302926241056 2094 1356692 SGTC_301 4119-0100 24.5 µM 0.152488733454069 0.456881386917443 no 1489 0.439400737961651 2022 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_981 1488-1094 54.9 µM 0.15107047838251 0.457363457596312 no 1490 0.439960060015749 2085 3449522 SGTC_1097 itavastatin 7.23 µM 0.150048604515365 0.457710835618332 no 1491 0.440363134222959 2081 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_885 0865-0106 16.8 µM 0.149761834104249 0.457808326791777 no 1492 0.440476260830294 2092 2793380 SGTC_1178 0988-0033 191 µM 0.148434895253201 0.458259469142041 no 1493 0.440999781328991 2082 5392207 SGTC_3245 9134821 49.47 µM 0.147639261592501 0.458530000304285 no 1494 0.441313734176468 2002 17014901 SGTC_1016 4226-1401 38 µM 0.147498050502801 0.458578016875186 no 1495 0.441369459187252 2143 2901613 SGTC_1356 1502-0781 85.8 µM 0.146872313229217 0.458790796083391 no 1496 0.441616402869663 2024 567702 SGTC_2040 5100729 123 µM 0.145830022879901 0.459145248517447 no 1497 0.442027787213213 2075 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1619 st003326 88.7 µM 0.145538051243562 0.459244545359041 no 1498 0.442143037504085 2154 2849032 SGTC_923 1900-2434 73.3 µM 0.145454304800953 0.45927302721582 no 1499 0.44217609573538 2123 5910570 SGTC_2279 7948423 32.93 µM 0.144340215788902 0.459651944617786 no 1500 0.442615911590639 2171 1247112 SGTC_1758 st042942 75.2445 µM 0.144058536713256 0.459747753466717 no 1501 0.442727123016464 2160 669317 SGTC_2830 7992007 71.43 µM 0.143526328868582 0.45992878223809 no 1502 0.442937259537969 1971 1952075 SGTC_1078 idebenone 36.1 µM 0.141804128705832 0.46051463977984 no 1503 0.443617361396384 2082 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_979 1426-2828 121 µM 0.141539055853247 0.460604819828666 no 1504 0.443722054238252 2094 747872 SGTC_2614 arthonioic acid 13.39 µM 0.141382449897328 0.460658099465138 no 1505 0.443783908976773 2143 6710684 SGTC_2863 9028737 58.44 µM 0.14089225593212 0.460824875181938 no 1506 0.443977529996308 2175 6460917 SGTC_1210 3013-0140 750 nM 0.140642581960911 0.460909822891935 no 1507 0.444076153507434 2181 905973 SGTC_3156 9099931 49.47 µM 0.138855280742118 0.46151797636811 no 1508 0.44478225466966 2069 18111053 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.138756271751159 0.461551668163723 no 1509 0.444821374855999 2005 4174840 SGTC_92 0063-0024 660.874 µM 0.138615137800293 0.461599695149991 no 1510 0.444877140280747 2190 3594437 SGTC_2894 9048625 32.47 µM 0.137077977805065 0.462122817039682 no 1511 0.44548457965051 2166 4092861 SGTC_2300 7976697 71.57 µM 0.136941867140568 0.462169141002697 no 1512 0.445538372678688 2028 2236109 SGTC_3210 9128157 49.47 µM 0.136487847969174 0.462323665793052 no 1513 0.445717815283621 1904 17590849 SGTC_2051 5263410 176 µM 0.135326985108635 0.4627187896482 no 1514 0.446176675145495 2189 227584 SGTC_3213 9129884 49.47 µM 0.134790394397608 0.462901441929857 no 1515 0.44638880034355 2034 17190742 SGTC_3243 9134147 49.47 µM 0.133975448244545 0.463178859694073 no 1516 0.446710994423278 2184 24282180 SGTC_497 capsazepine 133 µM 0.132544149971633 0.463666134617706 no 1517 0.447276952208187 2023 2733484 A calcium channel blocker. SGTC_1776 st049249 45.9 µM 0.13078675360997 0.464264501708168 no 1518 0.447972001035003 2017 1822314 SGTC_3262 9137218 49.47 µM 0.130556612817683 0.464342867209514 no 1519 0.448063033407251 2183 17650664 SGTC_2755 lomerizine 42.69 µM 0.130105371124817 0.46449652404065 no 1520 0.448241530350254 2072 3949 A calcium channel blocker. SGTC_420 mitomycin C 81.9 mM 0.129322086219026 0.464763260793678 no 1521 0.448551397950455 2048 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2332 7982454 138.89 µM 0.129025209128565 0.464864362292168 no 1522 0.448668850775487 2172 2981748 SGTC_3236 9132701 49.47 µM 0.128921685760155 0.464899617710873 no 1523 0.448709808554676 2062 24282524 SGTC_2106 5357045 167.29 µM 0.12802813531422 0.465203932362394 no 1524 0.44906335374873 2150 668842 SGTC_3266 9136860 49.47 µM 0.127442947964613 0.465403239463001 no 1525 0.449294912892179 2168 4871271 YPR165W RHO1 SGTC_1738 st035555 74 µM 0.125991659434064 0.465897566559863 no 1526 0.449869263385483 2108 5331140 SGTC_1874 staurosporine 7.6 µM 0.125736556821724 0.465984463172138 no 1527 0.449970231668987 2158 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1201 1889-3372 45.9 µM 0.124968153285619 0.46624621729191 no 1528 0.450274381324734 2063 5392199 SGTC_1851 st056236 18.9 µM 0.124575306285451 0.466380044969259 no 1529 0.450429889404737 2200 5393171 SGTC_2369 9071472 200 µM 0.124171797350614 0.466517508710025 no 1530 0.450589625923599 2114 17296037 SGTC_445 e6 berbamine 66 µM 0.124168932800157 0.466518484593226 no 1531 0.450590759937832 2097 6610268 A calcium/calmodulin antagonist. SGTC_2329 6138490 200 µM 0.123709760791907 0.466674916011735 no 1532 0.450772541518982 2038 720019 SGTC_1121 fusaric acid 630.51 nM 0.119822623016792 0.467999395882194 no 1533 0.452311830239832 2033 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1370 2001-0092 44.6 µM 0.117015848540148 0.468955980420152 no 1534 0.453423747221649 2171 790957 SGTC_1101 ebselen 5.29 µM 0.116892637070354 0.468997976607514 no 1535 0.453472566460039 2213 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_984 1492-0255 2.91 µM 0.116251614513272 0.469216472401014 no 1536 0.453726565774085 2123 1585198 SGTC_928 2764-0428 58.7 µM 0.116168960376779 0.469244646159296 no 1537 0.453759318098117 2122 662578 SGTC_2553 4-methylesculetin 85.09 µM 0.11614720541659 0.469252061651518 no 1538 0.453767938717212 2080 5319502 SGTC_764 1951-2361 146 µM 0.115914358475464 0.469331431560135 no 1539 0.45386020799423 2015 5438930 SGTC_3009 9080819 71.4286 µM 0.115610199244562 0.469435111331847 no 1540 0.453980739642601 2101 17027216 SGTC_3005 9076496 71.4286 µM 0.113682142875754 0.470092382257119 no 1541 0.454744884330534 2226 21368410 SGTC_2449 5812982 45.77 µM 0.113312710166811 0.470218330557274 no 1542 0.454891320442603 2202 776185 SGTC_522 1273-0010 11.6 µM 0.113287001116757 0.470227095488188 no 1543 0.454901511250325 2125 5705015 SGTC_2904 7225135 42.03 µM 0.112986889355017 0.470329413008919 no 1544 0.455020474714629 2214 4446116 SGTC_1194 1488-0194 225 µM 0.112966845817527 0.470336246549918 no 1545 0.455028420060741 2107 1391452 SGTC_2344 7990960 76.95 µM 0.112335619943793 0.470551457925028 no 1546 0.455278649951986 2105 140813 SGTC_3107 9121808 49.47 µM 0.111468523348312 0.470847101532439 no 1547 0.45562241237331 2205 662681 SGTC_135 0933-0004 26.348 µM 0.111350943596266 0.470887192542035 no 1548 0.455669029697978 2078 21230617 YGL099W LSG1 SGTC_1341 1486-1360 280 µM 0.111022885047515 0.470999051782077 no 1549 0.455799099636205 2116 3976547 SGTC_1278 0874-0585 172 µM 0.110634431328511 0.471131507126947 no 1550 0.455953121412997 2134 766306 SGTC_3044 9093193 49.47 µM 0.1083973619436 0.471894367026668 no 1551 0.456840246835339 2079 25236277 SGTC_423 5-fluorouracil 457 µM 0.108170249551821 0.471971820118366 no 1552 0.456930321937093 2040 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2189 6047310 154.431 µM 0.107416267775193 0.472228961271018 no 1553 0.457229374678011 2180 711535 SGTC_1310 1188-0297 994 nM 0.106414183231202 0.472570734344467 no 1554 0.457626870191033 2150 1588352 SGTC_206 4546-0025 72.014 µM 0.106346562161054 0.472593798059843 no 1555 0.457653694880115 2113 6620745 YIL048W NEO1 SGTC_2206 7254556 146.969 µM 0.10396634186332 0.47340568471199 no 1556 0.458598029542068 2212 4398905 SGTC_3123 9126162 49.47 µM 0.103262422644633 0.473645810957978 no 1557 0.458877349263217 2209 25239884 SGTC_77 0828-0286 12.516 µM 0.103070891667846 0.473711149113819 no 1558 0.458953353519309 2222 745345 SGTC_2581 avocatin a 64 µM 0.102303512281751 0.473972937101909 no 1559 0.459257883769868 2141 6710728 A skin care supplement. SGTC_2681 menadione 3.18 µM 0.102221970576885 0.474000755346329 no 1560 0.459290244551232 2156 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_2914 7968218 45.32 µM 0.101663820894339 0.47419117350466 no 1561 0.459511760026243 2197 2977111 SGTC_1217 1183-1422 255 µM 0.10148867687167 0.474250926798125 no 1562 0.459581272847947 2191 2849664 SGTC_584 0986-0246 15.4 µM 0.100839080798795 0.474472552339719 no 1563 0.459839101474894 2242 53315 YDR232W HEM1 SGTC_913 3487-1245 167 µM 0.100439227801232 0.474608975873211 no 1564 0.459997813962924 2159 4016153 SGTC_2854 9024559 71.43 µM 0.100334420752692 0.474644734877544 no 1565 0.460039415775414 2141 3163529 SGTC_830 4076-0286 57.8 µM 0.0996405655890824 0.474881475714514 no 1566 0.460314843689171 2157 6866659 SGTC_2423 st077119 87.2 µM 0.099190111642059 0.47503517370234 no 1567 0.460493662953471 2211 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1413 3910-0535 34.4 µM 0.0980521931437312 0.475423455823304 no 1568 0.460945424433409 2212 2876951 SGTC_1684 st024538 14.6195 µM 0.0978329640228413 0.47549826417957 no 1569 0.461032465713288 2123 6732859 SGTC_722 3534-0461 190 µM 0.0971101729338281 0.475744910935385 no 1570 0.461319451107185 2136 658262 SGTC_1914 st062367 72.6 µM 0.0966157076374906 0.475913648675879 no 1571 0.461515790981751 2162 978205 SGTC_2528 xanthyletin 44.79 µM 0.0961599774980819 0.476069171755815 no 1572 0.461696758396295 2143 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2267 7931562 200 µM 0.0956781838887933 0.476233593254432 no 1573 0.461888084065044 2007 934880 SGTC_2707 st078556 66.6 µM 0.0941848506936223 0.476743248019791 no 1574 0.462481159335426 2256 17250899 SGTC_2936 9038235 15.59 µM 0.0939259596069017 0.476831607998559 no 1575 0.462583986103925 2237 4749415 SGTC_3030 9087619 49.47 µM 0.0923255629343823 0.477377851289848 no 1576 0.463219689410322 2202 25236973 SGTC_1446 4239-0190 62 µM 0.0919544337695494 0.477504530254309 no 1577 0.463367121362279 2078 1340085 SGTC_2459 5811157 9.22 µM 0.0919380124107203 0.477510135473334 no 1578 0.463373644902895 2249 2870684 YBR192W RIM2 SGTC_134 0269-0018 6.916 µM 0.0907706845004806 0.477908599131781 no 1579 0.463837402121932 2144 4378915 SGTC_729 4092-0585 94.1 µM 0.0896818643094114 0.478280284345554 no 1580 0.464270014022698 2167 2169061 SGTC_1877 wortmannin 25 µM 0.0880444292048504 0.478839283009835 no 1581 0.464920681915321 2249 312145 A covalent inhibitor of PI 3-kinase. SGTC_1597 7-benzyloxygramine 47.5 µM 0.0874832823806722 0.479030860738334 no 1582 0.465143686603964 2182 260807 SGTC_3026 9090633 49.47 µM 0.0868957952825146 0.47923143633012 no 1583 0.465377170878915 2208 25236842 SGTC_26 0302-0163 425.158 µM 0.0862994145794105 0.479435053691327 no 1584 0.465614201919676 2190 3100915 SGTC_1406 3909-7906 11.9 µM 0.0852120905388912 0.479806303575516 no 1585 0.466046389341683 2251 X1406 SGTC_963 1269-2853 151 µM 0.0843009309881658 0.480117418338467 no 1586 0.466408586108656 2181 3668223 SGTC_1801 st050089 28.441 µM 0.0836413598368361 0.480342635994554 no 1587 0.466670790868665 2257 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_864 0469-0573 172 µM 0.0835473342716061 0.480374742546731 no 1588 0.46670817080784 2099 689425 SGTC_574 1315-0397 40 µM 0.0827052226362911 0.480662300856071 no 1589 0.467042966019804 2250 6794277 SGTC_540 1187-0821 17.3 µM 0.0822174508571646 0.480828866316224 no 1590 0.467236898324182 2094 847520 SGTC_2764 methyldopa 94.69 µM 0.0793500230798482 0.481808109051147 no 1591 0.468377109518508 2247 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_80 0159-0065 512.242 µM 0.0788859989542374 0.481966586377623 no 1592 0.46856164987497 2263 1548079 SGTC_1175 0741-0056 27.6 µM 0.0783573744939944 0.482147130011333 no 1593 0.468771889729873 2248 765927 SGTC_1113 artemisinin 1.17947 µM 0.0782774639361991 0.482174422564832 no 1594 0.468803671810832 2286 2240 An anti-malaria and mitochondrial poison. SGTC_2515 chrysin 20.77 µM 0.0782251504167585 0.482192289705091 no 1595 0.468824478086764 2238 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1373 2887-0003 58.5 µM 0.0776996487469587 0.482371771331005 no 1596 0.46903348676115 2199 776948 SGTC_1714 st033236 13.627 µM 0.0775281141695584 0.482430358608645 no 1597 0.469101713351184 2242 2916566 SGTC_1188 1403-0014 4.57 µM 0.0751972296469194 0.483226504443433 no 1598 0.470028894268542 2197 9614867 SGTC_2057 5236571 38.335 µM 0.0748137823367061 0.483357482664955 no 1599 0.470181437915892 2243 54684039 YBR257W POP4 SGTC_2889 9059656 51.95 µM 0.0741562927035173 0.483582072642114 no 1600 0.470443011709019 2228 3949838 SGTC_1043 0916-0009 19.3 µM 0.0732196385631884 0.483902030592928 no 1601 0.470815669509123 2298 3101130 SGTC_2617 dihydrotanshinone i 20.83 µM 0.072831113483707 0.484034752526294 no 1602 0.470970255857616 2245 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1468 k284-1086 134 µM 0.0726519097897283 0.484095969919813 no 1603 0.471041558894229 2186 15996457 SGTC_2701 st077767 14.721 µM 0.0722182942465026 0.484244097953316 no 1604 0.47121409324187 2224 5721188 SGTC_3128 9127691 49.47 µM 0.0719739420269972 0.484327572428046 no 1605 0.471311322652692 2199 41316314 SGTC_459 nigericin 15.3 µM 0.0718183093047278 0.484380739316883 no 1606 0.471373250863646 2211 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2694 st077685 81.9 µM 0.0709786079824495 0.484667600898023 no 1607 0.47170739044954 2250 2838096 SGTC_1645 Cervolide 78 µM 0.0707523363989174 0.484744901918515 no 1608 0.471797433372819 2215 23173 A fragrance. SGTC_381 3461-2219 42.7 µM 0.0705594935052625 0.484810783169088 no 1609 0.471874174760764 2280 2883159 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.0699844111760019 0.485007251992595 no 1610 0.472103033645857 2134 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_367 0335-0881 7.1 µM 0.0693082349436839 0.485238262784318 no 1611 0.472372135482662 2233 23828853 SGTC_1462 k081-0014 26.5 µM 0.0686345874493057 0.485468414577442 no 1612 0.472640243483871 2270 3270634 SGTC_2331 7980721 200 µM 0.0681240741911846 0.485642834756508 no 1613 0.472843433218865 2237 2981221 SGTC_2416 tofa 880 nM 0.0672245436417733 0.485950171889666 no 1614 0.473201473158235 2030 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_905 2-aminofluorene 215 µM 0.0665146543697664 0.48619272134158 no 1615 0.473484045523273 2294 1539 An established DNA mutagen. YPR165W RHO1 SGTC_48 0382-0018 55 µM 0.0652956123612013 0.486609246012374 no 1616 0.473969317859931 2298 762596 SGTC_3071 9117417 49.47 µM 0.0647294327849792 0.486802704359026 no 1617 0.474194713991695 2277 45595590 YGL055W OLE1 SGTC_3094 9117742 49.47 µM 0.0639763691640555 0.487060024067408 no 1618 0.474494521463954 2302 17149698 SGTC_2397 5161689 200 µM 0.0631696226673064 0.487335693036809 no 1619 0.474815717026063 2245 2259942 SGTC_1165 k072-0275 30.3 µM 0.0631038473753099 0.487358169023624 no 1620 0.474841905322476 2285 6153523 YGL055W OLE1 SGTC_2309 7664088 163.95 µM 0.0594202090486441 0.488616962140028 no 1621 0.476308708502145 2318 704922 SGTC_153 4077-0274 519.67 µM 0.0584807930480221 0.4889380031802 no 1622 0.476682830617447 2307 3121976 SGTC_1970 st070122 35.8 µM 0.0582990506786302 0.489000113621858 no 1623 0.476755211839756 2272 102928 SGTC_866 0495-0101 262 µM 0.0580868881425802 0.489072620490646 no 1624 0.476839709252416 2180 635694 SGTC_2248 tofa 1.1 µM 0.057951173820637 0.489119001255745 no 1625 0.476893760383178 2225 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1399 3562-5772 25 µM 0.0578634693054195 0.489148974607769 no 1626 0.476928690807984 2297 23847490 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.0570217000706922 0.489436655540924 no 1627 0.477263954553046 2323 229346 A bile salt which induces apoptosis. SGTC_544 k015-0020 52.4 µM 0.0568675757199197 0.489489329290428 no 1628 0.477325341662481 2238 3008304 SGTC_413 propylparaben 100 µM 0.0568481981187664 0.489495951818967 no 1629 0.47733305972124 2254 7175 A pharmaceutical preservative. SGTC_2797 7859098 81.82 µM 0.0567704204552848 0.489522533301178 no 1630 0.477364038490458 2266 972681 SGTC_3054 9094397 49.47 µM 0.0560578898623849 0.489766051629391 no 1631 0.477647845089213 2286 2598354 SGTC_1785 bathophenanthroline 24 µM 0.0551439080489916 0.490078424594377 no 1632 0.47801190788751 2196 72812 An iron chelator. SGTC_348 k064-0012 10.7 µM 0.0550310622297164 0.4901169925089 no 1633 0.478056858599779 2295 5066323 SGTC_3120 9124077 49.47 µM 0.0546972143358004 0.490231094015021 no 1634 0.47818984434014 2326 18774327 YGL155W CDC43 SGTC_1879 gemcitabine 100 µM 0.0542602389078421 0.490380443339017 no 1635 0.478363913807566 2287 60750 A nucleoside analog which inhibits DNA replication. SGTC_1707 st032323 6.317 µM 0.0518356557254103 0.491209140540544 no 1636 0.479329822284404 2258 3132057 YMR211W DML1 SGTC_430 0958-0115 16.4 µM 0.0509672464494271 0.491505963174096 no 1637 0.479675810079626 2159 6833180 SGTC_1788 fluconazole 20 µM 0.0501799249943846 0.491775074028109 no 1638 0.479989504465478 2188 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1539 benzyladenosine 56 µM 0.0498006040385251 0.491904729385255 no 1639 0.480140642664488 2313 92208 A nucleotide analog. SGTC_1982 st072467 71.9 µM 0.0492890493373756 0.492079584792762 no 1640 0.480344473137413 2193 3163533 SGTC_3076 9116187 49.47 µM 0.0489274980374578 0.492203168195167 no 1641 0.480488537417592 2302 27241210 SGTC_851 0394-0702 453 µM 0.0485043088264153 0.492347821266459 no 1642 0.480657165269345 2325 762646 SGTC_1224 0823-0416 294 µM 0.0478269730166764 0.49257934793477 no 1643 0.480927069895296 2305 3598164 SGTC_3339 9145883 14.936 µM 0.0475784627052947 0.492664294265676 no 1644 0.48102609842909 2312 2030670 SGTC_1039 k821-0043 94 µM 0.0466860565716526 0.492969341170869 no 1645 0.481381721736173 2306 15992768 SGTC_2990 9074105 71.4286 µM 0.0463928072180672 0.493069582096071 no 1646 0.481498584675233 2332 6502001 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.045963830926081 0.493216219115184 no 1647 0.481669539082116 2288 279621 SGTC_2825 7998094 58.44 µM 0.0449512123153377 0.493562366260843 no 1648 0.482073098272581 2283 2987815 SGTC_1578 josamycin 24.2 µM 0.0448380707569748 0.493601042161898 no 1649 0.482118189759358 2197 5282165 A P450 substrate. SGTC_755 1995-0008 37.3 µM 0.0447508589160419 0.493630854383212 no 1650 0.482152947361218 2321 689533 SGTC_2359 9039622 200 µM 0.0441265443651623 0.493844269133866 no 1651 0.482401767022153 2307 6463596 SGTC_2532 xanthone 78.9 µM 0.0438963092118388 0.493922972821643 no 1652 0.482493528644604 2315 7020 An insecticide. SGTC_390 dec-rvkr-cmk 16.7 µM 0.0438566075426558 0.493936544481989 no 1653 0.482509352080516 2290 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2473 5854593 8.94 µM 0.0434286858736838 0.494082826117593 no 1654 0.482679905623289 2323 2872951 SGTC_1393 3470-5649 58.2 µM 0.0430927495636877 0.494197663844776 no 1655 0.482813799471123 2278 4108395 SGTC_449 xestospongin c 11.1929 µM 0.0428555849851088 0.49427873736326 no 1656 0.482908327122555 2318 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_488 nitrendipine 139 µM 0.0413987521043809 0.494776753415407 no 1657 0.483489003811201 2343 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1094 duloxetine 25.4 µM 0.0409489883416245 0.494930506138191 no 1658 0.48366828156275 2339 60834 A selective serotonin reuptake inhibitor. SGTC_405 ebelactone b 50 µM 0.0404451522481495 0.495102744498347 no 1659 0.483869116695074 2240 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1384 3089-0840 101 µM 0.0381110437378162 0.495900680122997 no 1660 0.484799573039347 2331 1069836 SGTC_1214 0358-0031 63.7 µM 0.0371637503366132 0.496224525604214 no 1661 0.485177220837211 2330 4301366 SGTC_1166 k206-0078 225 µM 0.0365096362540037 0.496448145105175 no 1662 0.485437997606818 2341 5404595 SGTC_2776 terbinafine 19.92 µM 0.0360533877104198 0.496604121729536 no 1663 0.485619894680307 2338 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2030 5175110 200 µM 0.035192428952968 0.496898457084692 no 1664 0.485963149656792 2316 2831986 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.0332318573576004 0.49756872234035 no 1665 0.486744846824092 2354 65057 A dermal irritant. YDR527W RBA50 SGTC_946 3434-1334 87.4 µM 0.0330229609981224 0.497640138671419 no 1666 0.486828138698115 2318 4047976 SGTC_1617 st002906 78 µM 0.0328532446918304 0.497698160398564 no 1667 0.486895808989949 2355 5150859 SGTC_1478 0453-0656 35.7 µM 0.0327532719821778 0.497732338570886 no 1668 0.486935670878161 2342 5258496 SGTC_2587 piperic acid 92.2 µM 0.0324855138009317 0.497823878486314 no 1669 0.487042434122784 2320 5370536 SGTC_1149 3909-7961 23.3 µM 0.0322884593095584 0.497891246628196 no 1670 0.487121006272173 2251 735261 SGTC_1252 0493-0875 34.8 µM 0.0320924779772502 0.49795824794272 no 1671 0.487199151013368 2345 3960963 SGTC_2389 9091542 195.52 µM 0.0314324794083193 0.49818388602794 no 1672 0.487462319559799 2264 3626624 YOL127W RPL25 SGTC_1838 st055369 84.5 µM 0.0309353836010743 0.498353831853799 no 1673 0.487660535692837 2342 676036 SGTC_3127 9126946 49.47 µM 0.0307066352091153 0.498432035863238 no 1674 0.487751749763772 2260 27243249 SGTC_680 0417-1641 114 µM 0.0299227292867578 0.498700036376625 no 1675 0.488064339307291 2328 2835990 SGTC_68 0986-0284 82.829 µM 0.0281891067047223 0.499292726425159 no 1676 0.488755662681761 2178 423278 YIL048W NEO1 SGTC_3221 9128209 49.47 µM 0.0271078326145014 0.49966239276088 no 1677 0.489186863767333 2342 16460723 SGTC_1474 0330-0125 5.35 µM 0.026354504698378 0.499919940942818 no 1678 0.489487290761941 2363 X1474 SGTC_2743 auranofin 4.32 µM 0.0258861596038494 0.499919940942818 no 1679 0.489674069692397 2344 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.0255560490808552 0.499807082556607 no 1680 0.489805721180744 2365 1273210 SGTC_3349 9149703 23.001 µM 0.0253038927739443 0.499720875215086 no 1681 0.48990628447101 2368 4910494 SGTC_3214 9129694 49.47 µM 0.0252950370267501 0.499717847607415 no 1682 0.489909816272522 2350 17158655 SGTC_962 1254-0300 21.5 µM 0.0252709468719694 0.49970961165227 no 1683 0.489919423782612 2348 7340576 SGTC_2566 crystal violet carbinol 226 nM 0.0247741470518155 0.499539765493785 no 1684 0.490117556195908 2266 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2787 5284540 71.43 µM 0.023746719843249 0.499188508491138 no 1685 0.490527319726697 2323 736958 SGTC_1731 st035964 63 µM 0.0232504772949738 0.499018853206145 no 1686 0.490725237207518 2196 6739575 SGTC_2193 5925765 200 µM 0.0231774504811509 0.498993886830555 no 1687 0.490754362842361 2346 877370 SGTC_2407 paclitaxel 400 µM 0.0230496857151105 0.498950206677022 no 1688 0.490805319996028 2288 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2112 5488546 200 µM 0.0230340254598557 0.498944852757739 no 1689 0.490811565875698 2367 600757 SGTC_2766 oltipraz 83.91 µM 0.0214278174522455 0.498395724447671 no 1690 0.491452191769544 2367 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_556 4058-0063 51.5 µM 0.0210080964508686 0.498252231234876 no 1691 0.491619598534091 2345 6615692 SGTC_97 0535-0701 19.132 µM 0.0202530963661929 0.497994114192057 no 1692 0.491920735890336 2366 2832013 YGL099W LSG1 SGTC_2842 9000675 19.48 µM 0.0197325054191551 0.497816136686978 no 1693 0.492128380124457 2339 2989072 SGTC_2323 6148992 148.28 µM 0.0195098003198744 0.497739999308614 no 1694 0.492217209503597 2351 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_489 paxilline 115 µM 0.0185074954517317 0.497397337064288 no 1695 0.492616999042378 2318 105008 A toxic potassium channel blocker. SGTC_2246 7293507 91.5585 µM 0.0160831908230207 0.496568538124211 no 1696 0.49358401178103 2367 887656 SGTC_1954 st077032 68.9 µM 0.0139297216594263 0.495832342228099 no 1697 0.494443024786347 2264 698907 SGTC_2964 9083345 53.42 µM 0.0138413495975735 0.495802131192646 no 1698 0.49447827673962 2365 17741579 SGTC_3161 9100388 49.47 µM 0.0130563100520963 0.495533757207933 no 1699 0.494791433876251 2380 25236368 SGTC_1244 0416-0015 52.5 µM 0.0128792047295654 0.495473212174982 no 1700 0.494862082736898 2377 96201 SGTC_2483 5729050 27.16 µM 0.0114373037642189 0.494980289482823 no 1701 0.495437275431334 2384 2865180 SGTC_2468 5987765 72.9 µM 0.0107395003510966 0.494741743809969 no 1702 0.495715641597133 2335 26772094 SGTC_3253 9135987 49.47 µM 0.0102613164302255 0.494578276637122 no 1703 0.495906398862557 2385 4182430 SGTC_179 1273-0063 6.77 µM 0.00995978723837921 0.494475199349498 no 1704 0.496026685457303 2386 3108139 SGTC_384 k007-0144 5.16 µM 0.00881248425475257 0.494082999030754 no 1705 0.496484372939328 2379 6824886 SGTC_3315 9136395 68.55 µM 0.00862613105001324 0.494019295563298 no 1706 0.496558714285676 2396 16876844 SGTC_1041 0206-0046 107 µM 0.00682212034524241 0.493402615948114 no 1707 0.497278388863544 2342 50494 SGTC_2975 9084847 53.72 µM 0.00599564702845673 0.493120101046325 no 1708 0.497608097232594 2347 27211724 SGTC_261 5-fluorouridine 15.376 µM 0.00480801916287712 0.492714138095846 no 1709 0.498081885261143 2398 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1282 0886-0010 32.4 µM 0.00419322892965182 0.492503989298103 no 1710 0.498327148590899 2396 2836211 YNL267W PIK1 SGTC_782 0083-0095 30.5 µM 0.00402465565505081 0.492446367613255 no 1711 0.498394399029693 2394 3591729 An indicator and reagent. SGTC_663 1486-0733 13.9 µM 0.00319928586623915 0.492164242165818 no 1712 0.498723671778162 2395 722445 YPR165W RHO1 SGTC_1440 4100-1550 40 µM 0.00244839549678255 0.491907578453484 no 1713 0.499023232493084 2399 742806 SGTC_2950 9072895 21.46 µM 0.000245085956387265 0.491154479451606 no 1714 0.499902224850643 2403 17332245 SGTC_1968 st069590 43.6 µM 0.00017733148070296 0.491131321217897 no 1715 0.499929254975072 2405 6384066 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.00179852373009543 0.490455994552566 no 1716 0.499282493228578 2412 115019 SGTC_366 0181-0206 4.31 µM -0.0028079934076288 0.490110978802184 no 1717 0.49887977417874 2411 274874 SGTC_1018 4259-0013 28.1 µM -0.00292578795956894 0.490070719550231 no 1718 0.498832781144717 2421 6801262 SGTC_1359 1582-0056 520 nM -0.00421545034808057 0.489629951685358 no 1719 0.498318283605909 2416 3661189 SGTC_2409 alverine citrate 63.97 µM -0.00531169942701141 0.489255296616091 no 1720 0.497880948482326 2444 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.00596795885497577 0.489031017320275 no 1721 0.497619143018041 2426 688669 SGTC_1747 st037496 66.6 µM -0.00829806308937123 0.488234723344921 no 1722 0.496689589779544 2427 723305 SGTC_1374 2889-5571 141 µM -0.00846489957086785 0.488177710109802 no 1723 0.496623033991026 2436 2853281 SGTC_803 4488-1585 147 µM -0.00915663610814431 0.487941324726342 no 1724 0.496347081756152 2413 747204 SGTC_3143 9086658 49.47 µM -0.00949872701383616 0.487824424423674 no 1725 0.496210613167694 2446 25236626 SGTC_861 0443-0273 110 µM -0.0128155887405117 0.48669103250511 no 1726 0.494887459750241 2481 6149169 SGTC_3035 9091303 49.47 µM -0.0130399945362429 0.486614355453053 no 1727 0.494797942271287 2430 25237002 SGTC_965 1291-5240 308 µM -0.0138338092691367 0.486343121468678 no 1728 0.494481284607457 2437 2834598 SGTC_2495 cafestol 54.53 µM -0.013868087575162 0.486331409253097 no 1729 0.494467610853593 2517 16667697 An anti-infammatory. SGTC_2156 5649887 115 µM -0.0150906426210704 0.485913694288418 no 1730 0.493979933110019 2451 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3118 9124250 49.47 µM -0.0156783394170592 0.485712899193801 no 1731 0.493745503757728 2475 1504786 SGTC_2812 7970281 58.44 µM -0.0200474528061908 0.484220245516953 no 1732 0.492002759147181 2453 2233435 SGTC_2302 7771753 200 µM -0.0202539683141952 0.484149697350084 no 1733 0.491920388104751 2462 2203047 SGTC_826 1683-5028 118 µM -0.0207872393603402 0.483967527884597 no 1734 0.491707688528148 2467 722377 SGTC_2401 5128683 200 µM -0.0219380018732943 0.483574430066673 no 1735 0.49124870547541 2464 708373 SGTC_2911 7942208 15.64 µM -0.0224489357249062 0.483399901337643 no 1736 0.491044922554555 2466 1243384 SGTC_733 4069-0007 56.1 µM -0.0232311261108449 0.483132720881042 no 1737 0.490732955128402 2451 5717425 YNL287W SEC21 SGTC_2693 st077581 40.7 µM -0.0236540196442776 0.48298827212799 no 1738 0.490564291370372 2439 25238761 SGTC_784 4579-0127 173 µM -0.0247098529134863 0.482627638427626 no 1739 0.490143197996337 2501 1948547 SGTC_2170 morpholine 200 µM -0.024762542216638 0.482609642075017 no 1740 0.490122184435455 2467 121171 Reacts with secondary amines. SGTC_1219 1469-0211 33.1 µM -0.0248955031477662 0.482564228616264 no 1741 0.490069157046117 2450 6822282 SGTC_2307 7538926 6.34 µM -0.02590334292285 0.482220003391793 no 1742 0.489667216837866 2467 96582 SGTC_1198 1612-1005 86.7 µM -0.0268240500174705 0.481905549700959 no 1743 0.489300035488783 2478 6998509 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.0270656745453162 0.481823028326386 no 1744 0.48920367623487 2482 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2017 5132927 60.65 µM -0.0279422301943092 0.48152366719861 no 1745 0.488854113378009 2476 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2838 9002687 71.43 µM -0.0309384476555258 0.480500479243534 no 1746 0.487659313896793 2463 6457060 SGTC_1695 st026914 34.495 µM -0.0319815237405804 0.480144305630951 no 1747 0.487243392639589 2465 3289191 SGTC_1022 4477-0945 21.3 µM -0.0325382962748203 0.4799541939622 no 1748 0.487021388088309 2459 4648966 SGTC_1855 st056195 39.6 µM -0.0328463734531886 0.47984900203301 no 1749 0.486898548738918 2481 4028379 SGTC_2037 5169046 200 µM -0.0329627055215609 0.479809281199313 no 1750 0.486852164075641 2517 5718022 SGTC_2231 micatex 6.853 µM -0.0344536209129994 0.479300235652359 no 1751 0.486257712760232 2490 20737 An antifungal of unknown mechanism. SGTC_2086 5274770 176.623 µM -0.0345294706985334 0.479274339038285 no 1752 0.48622747106795 2481 689278 SGTC_2099 5377090 177.372 µM -0.0346291982956196 0.47924029020115 no 1753 0.486187709292255 2511 2243829 SGTC_692 k241-0027 77.8 µM -0.0379206917895344 0.478116600238218 no 1754 0.484875457625305 2502 3600480 SGTC_2945 9067681 61.76 µM -0.0389264240890549 0.477773285431823 no 1755 0.484474524577134 2463 16456930 SGTC_2043 5101342 149 µM -0.039666252120423 0.477520749699959 no 1756 0.484179603698578 2495 678451 SGTC_529 4076-0302 30.3 µM -0.0402043765330931 0.477337069917986 no 1757 0.483965094242039 2494 5816522 SGTC_2293 7624732 200 µM -0.0415013921005618 0.476894375174638 no 1758 0.483448091538044 2482 894453 SGTC_1562 morin hydrate 59.1 µM -0.0416569567898578 0.476841280052266 no 1759 0.483386083829705 2553 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2375 9072683 200 µM -0.0417503107616558 0.47680941800258 no 1760 0.483348873355498 2470 16798029 SGTC_3189 9110682 49.47 µM -0.0417930578164037 0.476794828326989 no 1761 0.483331834619704 2507 17122418 SGTC_2970 9090938 41.86 µM -0.043397486143087 0.476247255633015 no 1762 0.482692340791182 2492 17217104 SGTC_1783 st039459 87.517 µM -0.043462397129678 0.476225103206632 no 1763 0.48266646946441 2556 729761 SGTC_1186 1319-0216 26 µM -0.0445168157236917 0.475865267987232 no 1764 0.482246224127556 2518 4565136 SGTC_1059 3448-6867 171 µM -0.0445283928682447 0.475861317232041 no 1765 0.482241610090491 2466 3934407 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.0450489645018171 0.475683672164697 no 1766 0.48203414025753 2472 91467 include heat shock SGTC_725 1497-0963 19 µM -0.0451376438910885 0.475653410804394 no 1767 0.481998798250359 2485 3549977 SGTC_2031 5180455 200 µM -0.0465260294828523 0.475179650178011 no 1768 0.481445494009594 2486 29949 SGTC_739 1486-1183 203 µM -0.0465766143450123 0.475162389698015 no 1769 0.481425335423256 2473 4346692 SGTC_642 0335-0876 158 µM -0.0472095611926661 0.474946420610297 no 1770 0.481173103645205 2501 6812350 SGTC_2531 methyl deoxycholate 70.07 µM -0.04752255952963 0.474839624524215 no 1771 0.481048375370575 2502 16667744 Haematoxylin. SGTC_1996 st072960 66.8 µM -0.0480282364139823 0.474667089692206 no 1772 0.480846869581942 2468 1719405 SGTC_865 0488-0499 301 µM -0.0486405512780651 0.474458176791165 no 1773 0.480602876474087 2484 9634651 SGTC_1565 sinapyl alcohol 95.1 µM -0.0487971146697257 0.474404760770587 no 1774 0.480540490798574 2523 5280507 A phenol propionate derived from cinnamic acid. SGTC_917 harmaline 728.087 nM -0.0494745442912961 0.47417364184735 no 1775 0.480270561531572 2550 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2108 5365811 200 µM -0.0504090927902043 0.473854815860871 no 1776 0.479898195300664 2542 780283 SGTC_3164 9100705 49.47 µM -0.0519642243133012 0.473324312028163 no 1777 0.479278599871717 2562 17174235 SGTC_3319 9138450 16.7555 µM -0.0520036256208389 0.473310871624631 no 1778 0.47926290224864 2527 2029690 SGTC_2316 5844804 197.44 µM -0.0535710864111267 0.472776210989191 no 1779 0.478638446561158 2527 776813 SGTC_882 0843-0131 351 µM -0.0555240207638705 0.472110134110812 no 1780 0.477860496831451 2494 5425421 SGTC_500 h-89 112 µM -0.0557729878511379 0.472025225803657 no 1781 0.477761327005486 2528 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_309 k408-0051 1.48 µM -0.0571071795916391 0.47157023174575 no 1782 0.47722990863591 2515 3640463 SGTC_3028 9087778 49.47 µM -0.0575045323350505 0.471434731277086 no 1783 0.477071647901879 2517 17217395 SGTC_2336 9001819 198.65 µM -0.0612487200522202 0.470158097798535 no 1784 0.475580564772477 2564 2989602 SGTC_2925 9010536 32.5 µM -0.061499309983069 0.470072666439843 no 1785 0.475480781960798 2549 2994177 SGTC_947 3447-0010 211 µM -0.061566253544204 0.470049844210004 no 1786 0.475454125855446 2501 748350 SGTC_1631 benzylvanillin 81.9 µM -0.0615872557778648 0.470042684201804 no 1787 0.475445763046113 2615 75506 SGTC_1514 1189-1591 158 µM -0.0622101718514668 0.469830326241994 no 1788 0.475197731107724 2574 767698 YMR146C TIF34 SGTC_1625 st003711 30.1 µM -0.0625856719559144 0.469702318859204 no 1789 0.475048219585742 2571 24207034 YER133W GLC7 SGTC_1487 3970-0795 2.82 µM -0.0632100730709223 0.469489468460477 no 1790 0.474799611835586 2569 3765103 SGTC_3072 9116419 49.47 µM -0.0634536103290222 0.469406452066748 no 1791 0.474702649176671 2560 17170162 SGTC_274 sirtinol 40.1 µM -0.0636239908552549 0.469348373953986 no 1792 0.474634814250255 2543 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1239 0337-0584 35.4 µM -0.0665003121968051 0.468368013231881 no 1793 0.473489754582203 2595 914301 YML130C ERO1 SGTC_2308 7584454 197.62 µM -0.0669301379939701 0.468221528428311 no 1794 0.473318660087884 2547 893577 SGTC_1898 st060199 18.6 µM -0.0669673001155165 0.468208863764221 no 1795 0.473303867734178 2525 688866 SGTC_2748 diazoxide 86.69 µM -0.0685698611740053 0.467662749797539 no 1796 0.47266600484047 2590 3019 A potassium channel activatior. SGTC_2733 amorolfine 100 µM -0.0687214498799518 0.467611095175212 no 1797 0.472605672015042 2557 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3154 9100113 49.47 µM -0.0688836138166099 0.467555837593054 no 1798 0.472541130907325 2537 25237525 SGTC_1651 st011928 86.1 µM -0.0689954741234831 0.467517721405524 no 1799 0.472496611021196 2609 720198 SGTC_3052 9092717 49.47 µM -0.0702790025428386 0.467080382931491 no 1800 0.471985797360184 2620 25237534 SGTC_975 1335-0046 28.5 µM -0.0707476819249974 0.466920699011954 no 1801 0.471799285597737 2564 16486740 SGTC_17 0960-0276 49.807 µM -0.0713208754868124 0.466725413268804 no 1802 0.471571190649322 2531 6821114 SGTC_3330 9141424 71.43 µM -0.0715049973770916 0.466662685056953 no 1803 0.471497923704696 2567 27261020 SGTC_2362 9071156 126 µM -0.0718966459281283 0.466529257652871 no 1804 0.471342079652679 2593 653133 SGTC_1132 3456-3614 2.5 µM -0.0722093511926831 0.466422727463604 no 1805 0.471217651713624 2657 3125502 SGTC_1880 MG-132 525 µM -0.0740971376036589 0.465779661280535 no 1806 0.470466546431605 2572 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_2997 9067075 71.4286 µM -0.074299451886926 0.465710749075837 no 1807 0.470386056579338 2593 27209819 SGTC_3091 9116372 49.47 µM -0.0759349925697955 0.465153689839218 no 1808 0.469735408586097 2679 17169793 SGTC_1887 st057648 70.8 µM -0.0762347753685823 0.465051592275692 no 1809 0.469616158217982 2623 688672 SGTC_2176 5809774 33.9695 µM -0.0766956989994727 0.464894619181393 no 1810 0.469432813082775 2582 2870539 SGTC_3086 9117350 49.47 µM -0.0771823979555102 0.464728873920001 no 1811 0.469239222134252 2548 2679265 SGTC_1231 0242-0792 125 µM -0.0786847653984166 0.464217281624911 no 1812 0.468641681678488 2529 3707635 SGTC_285 1486-1325 46 µM -0.0796654306584333 0.463883373343035 no 1813 0.468251677186485 2603 22310230 SGTC_2006 4011487 200 µM -0.0798477649024297 0.46382129286241 no 1814 0.468179167336376 2608 45595294 SGTC_2754 granisetron 64.02 µM -0.0804414605022682 0.463619159719366 no 1815 0.467943076506684 2599 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_237 nikkomycin 200 µM -0.0810233965945576 0.463421039402063 no 1816 0.467711672940748 2572 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2905 7799065 20.05 µM -0.0810911446815718 0.463397975134101 no 1817 0.467684734008131 2597 1296806 SGTC_927 2425-1185 123 µM -0.0813428170336885 0.463312296470836 no 1818 0.467584661859045 2538 730375 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.0816396531755708 0.463211244555148 no 1819 0.467466633924702 2585 676296 Flavone; oxidizing agent. SGTC_2948 9070189 9.45 µM -0.0820310786752829 0.463077995218236 no 1820 0.46731099976084 2594 6473636 YDL196W YDL196W SGTC_464 bw-b 70c 158 µM -0.0822984761884179 0.462986969954213 no 1821 0.467204683068556 2668 5353454 SGTC_180 1486-1293 102.781 µM -0.0824917926650252 0.462921163954584 no 1822 0.467127822298251 2575 4140536 SGTC_201 4262-0159 12.803 µM -0.0828982074283599 0.462782821428714 no 1823 0.466966239700816 2620 1341029 SGTC_1856 st057054 55.7 µM -0.0838356228748051 0.462463744847753 no 1824 0.466593562372959 2657 1266018 SGTC_27 0485-0001 32.618 µM -0.0838835179678395 0.462447443008186 no 1825 0.466574522062969 2549 2054479 SGTC_1930 st074634 34.3 µM -0.0847990367831556 0.46213584410328 no 1826 0.466210579659661 2554 684253 YOR116C RPO31 SGTC_2784 7567673 72.73 µM -0.0864539531863646 0.461572648648402 no 1827 0.465552779497632 2552 3471247 SGTC_1228 0124-0032 52.5 µM -0.0864630307242521 0.461569559623399 no 1828 0.465549171593866 2598 X1228 SGTC_2792 7535235 81.82 µM -0.0872152286464751 0.461313599810014 no 1829 0.46525021738623 2631 1281891 SGTC_2513 baicalein 25.65 µM -0.0877650973684979 0.461126499221878 no 1830 0.465031689473705 2609 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_458 nppb 133 µM -0.0879127484775021 0.461076260313262 no 1831 0.464973012009 2604 4549 A chloride channel blocker. SGTC_511 blebbistatin 171 µM -0.0881535698809899 0.460994321154712 no 1832 0.464877309727315 2705 3476986 A myosin inhibitor. SGTC_1575 cyproterone acetate 48 µM -0.0884308011661231 0.460899995633606 no 1833 0.464767140696428 2582 9880 An androgen receptor antagonist and liver toxin. SGTC_1944 st076371 56.9 µM -0.088871029275781 0.460750216390233 no 1834 0.464592203857212 2567 24208455 SGTC_2618 avocadyne 43.43 µM -0.0903714467730691 0.460239769824547 no 1835 0.46399602300134 2593 3015189 SGTC_2195 6536160 144.242 µM -0.0906423608970795 0.460147610979644 no 1836 0.463888385662903 2573 3834386 SGTC_2350 9023895 38.85 µM -0.0912819017502147 0.459930062177408 no 1837 0.463634299128116 2653 2997209 SGTC_2823 7987624 58.44 µM -0.0916645594434326 0.45979990152112 no 1838 0.463482278135147 2659 2239440 SGTC_1570 verbenone 133 µM -0.0917462706701663 0.459772108081541 no 1839 0.463449816857191 2623 29025 A natural terpanoid with antifungal properties. SGTC_2270 7924575 90.91 µM -0.0919751477501994 0.459694258366103 no 1840 0.463358892550961 2767 1262135 SGTC_2556 citropten 84.59 µM -0.0921946539103982 0.459619597505118 no 1841 0.463271692758826 2568 2775 A potential DNA crosslinker. SGTC_845 0330-0138 4.51 µM -0.0926666398579636 0.459459065254853 no 1842 0.463084200237494 2550 9039800 SGTC_3015 9080845 49.47 µM -0.0929624334380793 0.459358463065586 no 1843 0.462966702856885 2661 5296973 SGTC_2450 5739737 12.93 µM -0.093240469888073 0.459263902616524 no 1844 0.462856262044422 2631 2262825 SGTC_1388 3346-4487 254 µM -0.0932480965921255 0.459261308800003 no 1845 0.462853232628008 2634 3345614 SGTC_1439 4092-1168 46 µM -0.0944611709181898 0.458848768429791 no 1846 0.462371412800881 2574 2886240 SGTC_2947 9072639 7.68 µM -0.0945107071715508 0.458831923158974 no 1847 0.462351738712428 2639 16488146 SGTC_3298 9116858 71.43 µM -0.0945168990599896 0.458829817554026 no 1848 0.462349279514733 2674 2506942 SGTC_3200 9114385 49.47 µM -0.0947837446889463 0.458739075499873 no 1849 0.462243299297732 2655 17018030 YLR208W SEC13 SGTC_1971 st069429 63.5 µM -0.0951461804975791 0.458615831020033 no 1850 0.46209935884832 2611 1246522 YGL099W LSG1 SGTC_901 1112-0062 60.1 µM -0.0970813067367861 0.457957868651238 no 1851 0.46133091289763 2573 1908457 SGTC_1952 st077036 64.1 µM -0.0994385622457804 0.457156533887235 no 1852 0.460395033114384 2577 2937007 SGTC_2143 5623677 140.463 µM -0.0994665986107847 0.457147004136007 no 1853 0.460383903400296 2562 5375313 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.100523070611434 0.456787920122517 no 1854 0.459964533950993 2590 16623 A steroid. SGTC_607 4491-0986 66.8 µM -0.101323637845557 0.45651583900001 no 1855 0.459646776233499 2643 698981 YDR232W HEM1 SGTC_2056 5235370 200 µM -0.102670797959799 0.456058038667688 no 1856 0.459112125492917 2630 5511916 SGTC_2736 butenafine 14.65 µM -0.103332533706674 0.455833184833992 no 1857 0.458849527825417 2617 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_422 cantharidin 155 µM -0.104818763418764 0.455328224570853 no 1858 0.458259810505704 2576 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1498 4478-3555 97.6 µM -0.105134786787445 0.4552208619904 no 1859 0.458134428193983 2595 3437919 SGTC_3202 9113761 49.47 µM -0.105353352657748 0.455146610546634 no 1860 0.458047714593245 2765 4798415 SGTC_596 1155-0152 116 µM -0.107138059950652 0.454540366639504 no 1861 0.457339726723991 2593 280313 SGTC_2589 lobaric acid 100 µM -0.107657103489778 0.454364073514709 no 1862 0.45713384906469 2651 73157 A novel microtubule depolymerizer. SGTC_411 enrofloxacin 100 µM -0.10831107808062 0.454141963864652 no 1863 0.456874467638583 2701 71188 A bacterial gyrase inhibitor. SGTC_2418 pentamidine 31.67 µM -0.110677165414102 0.45333848898048 no 1864 0.455936177037103 2577 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_604 1000-0114 314 µM -0.111968863855087 0.452899934973957 no 1865 0.455424047167916 2654 1572745 SGTC_24 0417-1663 219 µM -0.113525285300048 0.452371579277175 no 1866 0.454807058945466 2668 4329390 SGTC_1636 st007707 68.9 µM -0.114984940833772 0.451876149146807 no 1867 0.454228529170361 2679 403051 SGTC_638 3970-0837 4.09 µM -0.115610982285646 0.451663683712006 no 1868 0.453980429335106 2650 4118451 YLR208W SEC13 SGTC_2019 4016004 108 µM -0.117108745838373 0.45115543024013 no 1869 0.453386939625591 2685 45595336 SGTC_2685 mycophenolic acid 18.85 µM -0.117586641972323 0.450993277013907 no 1870 0.453197594836749 2659 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3095 9117207 49.47 µM -0.120009732752393 0.450171233171535 no 1871 0.452237719031038 2675 17015229 SGTC_2162 5663267 200 µM -0.120068298327478 0.450151367182708 no 1872 0.452214522474279 2629 6456493 SGTC_675 1309-0189 238 µM -0.120841536505927 0.449889089317263 no 1873 0.451908274890541 2666 4246530 SGTC_3195 9113082 49.47 µM -0.121381630822126 0.449705905461959 no 1874 0.451694382887082 2592 17018038 SGTC_2394 5221648 200 µM -0.12140616980476 0.449697582826447 no 1875 0.451684665116694 2717 788586 SGTC_789 1309-1135 70.6 µM -0.121510807143938 0.449662094299766 no 1876 0.451643227634296 2626 3092424 SGTC_1868 st057644 42.7 µM -0.123463815253346 0.448999791357257 no 1877 0.450869913133945 2610 688665 SGTC_3181 9108277 49.47 µM -0.12453804993358 0.448635557985155 no 1878 0.450444637688693 2640 17097298 SGTC_133 0724-0033 378.92 µM -0.124775951527118 0.448554900170721 no 1879 0.45035046324031 2598 280309 SGTC_2773 thioridazine 9.09 µM -0.125136709908166 0.44843259322578 no 1880 0.4502076606986 2608 5452 An antipsychotic. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.126605299805168 0.447934751845821 no 1881 0.449626401031068 2737 616764 SGTC_3187 9109394 49.47 µM -0.128660237778864 0.447238280510267 no 1882 0.448813249745589 2661 17098090 SGTC_2780 5215298 71.43 µM -0.129251334379453 0.447037972699808 no 1883 0.44857938893498 2692 2834131 SGTC_2180 6301957 200 µM -0.129691171179947 0.446888931804827 no 1884 0.448405383974666 2654 845462 SGTC_1937 st074714 47.2 µM -0.129807465703651 0.446849526078044 no 1885 0.448359378058792 2624 17250970 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.1312305341591 0.446367370178385 no 1886 0.447796471028086 2615 2333 A French combination drug. SGTC_1250 0485-0349 40.2 µM -0.131573766405609 0.446251090035905 no 1887 0.447660718236743 2675 6842794 YDL195W SEC31 SGTC_653 0203-0016 55.2 µM -0.131760246575974 0.446187916263274 no 1888 0.447586965487427 2716 295302 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.131849275167859 0.446157756583572 no 1889 0.44755175539373 2604 5355888 SGTC_2757 clomiphene 4.22 µM -0.132756871539223 0.445850313433259 no 1890 0.447192831943101 2760 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_2650 prasterone 100 µM -0.133878731088677 0.445470334851252 no 1891 0.446749234497678 2641 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1129 3453-1384 223 µM -0.135302296802731 0.444988239259426 no 1892 0.446186434596283 2869 1084452 SGTC_2536 dehydroabietamide 32.04 µM -0.135858456092856 0.444799915998774 no 1893 0.445966589062374 2767 3983547 SGTC_2985 9022375 71.43 µM -0.13651716308517 0.444576884781519 no 1894 0.44570622869487 2847 4939335 SGTC_209 4077-0173 175.592 µM -0.137999048034105 0.444075198464296 no 1895 0.445120584954102 2734 15993494 SGTC_942 3253-1115 227 µM -0.138528458621895 0.443895990274524 no 1896 0.444911389853591 2790 46497897 SGTC_1688 st021091 57.6 µM -0.138630969814401 0.4438612910365 no 1897 0.444870884616138 2633 3656366 SGTC_705 1124-0212 310 µM -0.138800027578922 0.443804067243851 no 1898 0.444804086095828 2655 9554485 SGTC_119 0121-0043 24.815 µM -0.139981424676171 0.443404212892543 no 1899 0.44433733341765 2638 1092378 SGTC_2983 9022671 12.99 µM -0.140858564408084 0.443107374400725 no 1900 0.443990838255304 2877 6405161 SGTC_1920 st075728 45.7 µM -0.141196831897259 0.442992907647965 no 1901 0.443857224391475 2730 3400306 SGTC_648 0375-0473 33.3 µM -0.141210196335301 0.442988385336934 no 1902 0.443851945640287 2676 1713139 SGTC_3265 9137266 49.47 µM -0.142256303440178 0.442634422596324 no 1903 0.443438780115468 2625 17224265 SGTC_689 0833-0039 98 µM -0.142321301929524 0.442612431094769 no 1904 0.44341311064301 2725 5374726 SGTC_1797 st048695 56.8 µM -0.143294238559661 0.442283270192313 no 1905 0.443028902920536 2771 592262 YIL048W NEO1 SGTC_2647 atorvastatin 60.16 µM -0.143691022250409 0.442149042989815 no 1906 0.442872230416445 2743 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_3018 9082602 49.47 µM -0.144858550042731 0.441754120807518 no 1907 0.442411276719047 2664 17332089 SGTC_3226 9131256 49.47 µM -0.14625190258551 0.441282888064748 no 1908 0.441861266834976 2643 17178073 SGTC_1962 st076595 64.5 µM -0.146594053956587 0.441167184931647 no 1909 0.441726223616729 2670 279619 SGTC_2481 5478948 45.16 µM -0.14983970998133 0.440069873367202 no 1910 0.440445539488957 2791 77792 SGTC_362 0310-0100 9.03 µM -0.149933389788809 0.440038208307806 no 1911 0.440408584112551 2781 790235 SGTC_1140 3229-1848 2.98 µM -0.1514845499619 0.439513950802702 no 1912 0.439796748768458 2773 2849525 SGTC_3311 9131146 2.8755 µM -0.152397415099282 0.439205472283679 no 1913 0.439436747858984 2742 4900406 YPR165W RHO1 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.152440831810641 0.439190801677802 no 1914 0.439419627127555 2796 6728940 SGTC_2847 9005661 71.43 µM -0.15356930398214 0.438809517712019 no 1915 0.438974670827241 2655 2991449 SGTC_74 000s-0487 160.283 µM -0.154569236625454 0.438471711634264 no 1916 0.438580462043813 2654 677548 SGTC_3168 9103419 49.47 µM -0.15610027192538 0.437954570699346 no 1917 0.437976992012775 2656 16649256 SGTC_1273 0849-0096 14.1 µM -0.156224075458832 0.437912757944003 no 1918 0.437928200125465 2728 5286025 SGTC_846 0335-0850 148 µM -0.157164815681662 0.437595059959872 no 1919 0.437557478334152 2684 6819598 SGTC_2349 9023730 187.07 µM -0.157956108912435 0.437327862955538 no 1920 0.437245692226683 2807 4126287 SGTC_2883 9059145 45.46 µM -0.160341308219615 0.436522623038271 no 1921 0.436306110272439 2662 16476510 SGTC_333 3486-0131 40.1 µM -0.160622367329055 0.436427755135211 no 1922 0.436195418528709 2832 6744690 SGTC_3284 9108171 64.8615 µM -0.161835843185532 0.436018203943293 no 1923 0.435717563153667 2795 8687505 SGTC_107 0358-0022 2.6945 µM -0.161934281435639 0.435984983785309 no 1924 0.435678803202434 2764 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1698 5-fluorocytosine 1.055 µM -0.166984551223463 0.434281270009907 no 1925 0.433691102294475 2739 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_884 0851-0618 334 µM -0.167107712399015 0.434239736568948 no 1926 0.433642648864544 2853 9642473 SGTC_2741 miltefosine 3.04 µM -0.167214026864269 0.434203884900157 no 1927 0.433600823981783 2730 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_1686 st019653 115.5 µM -0.168038923969888 0.433925729144754 no 1928 0.433276328770212 2718 97252 SGTC_279 1273-0055 2.93 µM -0.168866246759743 0.433646788307051 no 1929 0.432950924526765 2783 2847562 SGTC_796 1234-0020 70.7 µM -0.170111552096543 0.433226982474032 no 1930 0.432461204335487 2702 46495034 SGTC_2811 7967822 32.47 µM -0.171080178780243 0.432900500055459 no 1931 0.432080360567783 2833 2232244 SGTC_483 fpl-64176 144 µM -0.171506065022232 0.432756966591382 no 1932 0.431912930950828 2711 3423 SGTC_1901 st060216 58.6 µM -0.172197909835361 0.432523817888745 no 1933 0.431640970523857 2715 688792 SGTC_2140 5586273 200 µM -0.172732164902408 0.432343792317732 no 1934 0.431430979929851 2696 854421 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.173106358672582 0.432217710256664 no 1935 0.43128391345552 2685 6708784 An antioxidant flavonoid SGTC_2491 paeonol 100 µM -0.174861741837572 0.431626338115187 no 1936 0.430594136317447 2694 11092 Increases levels of cortical cytochrome oxidase. SGTC_3058 9093861 49.47 µM -0.175514625654635 0.431406426691701 no 1937 0.430337639773312 2885 17217477 SGTC_1281 0884-0031 11.8 µM -0.175703715632313 0.431342739317533 no 1938 0.430263358034203 2721 1548255 SGTC_1579 chlormadinone acetate 49.4 µM -0.176780885386414 0.43097997198726 no 1939 0.429840251911789 2885 45114258 A steroidal progestin. SGTC_2340 7987427 183.45 µM -0.178307500137478 0.430465941165176 no 1940 0.429240744471889 2841 2239331 SGTC_2629 bisabolol 100 µM -0.178899687154105 0.430266575843234 no 1941 0.429008234219051 2874 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_821 1114-0266 29.2 µM -0.179284918941708 0.430136893482752 no 1942 0.42885699396888 2803 3123235 SGTC_1378 2093-0007 380 nM -0.181666910078083 0.42933520065785 no 1943 0.427922067868585 2832 3618014 SGTC_2762 leflunomide 42.06 µM -0.181704061048147 0.429322699272221 no 1944 0.427907489387519 2730 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2182 6325192 200 µM -0.18177036710263 0.429300387310769 no 1945 0.427881470350279 2709 736248 SGTC_2474 5321570 43.32 µM -0.182075580782611 0.429197685940414 no 1946 0.427761706055594 2869 2841384 SGTC_1127 asiatic acid 681.4 nM -0.182265308430679 0.429133846887319 no 1947 0.427687261245817 2720 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1948 st076329 66.6 µM -0.183179615668455 0.428826229244295 no 1948 0.427328544041846 2689 24208413 SGTC_2226 7298446 200 µM -0.184054232656567 0.428532005793164 no 1949 0.426985455034125 2786 3283010 SGTC_1791 st048313 56.1 µM -0.187158257803603 0.42748812528459 no 1950 0.425768275963973 2873 1204976 SGTC_1687 st020778 55.3625 µM -0.187618184931943 0.427333495245965 no 1951 0.425587984939875 2767 4259299 SGTC_1324 1418-0026 34.4 µM -0.191474187926544 0.426037527126073 no 1952 0.42407705072558 2837 1372513 SGTC_392 N-ethylmaleimide 8.33 µM -0.193737723262741 0.425277144125017 no 1953 0.423190626263939 2803 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_534 k292-0788 63.4 µM -0.194689974553317 0.424957339924518 no 1954 0.422817830439752 2762 4146317 SGTC_2924 9010168 62.78 µM -0.194770383490193 0.424930337634447 no 1955 0.422786354391917 2835 2993929 SGTC_417 st075190 100 µM -0.196902410592479 0.42421450610156 no 1956 0.421951953614991 2898 222757 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.19775493562082 0.423928339269761 no 1957 0.421618402973439 2740 165521 SGTC_2608 thymoquinone 42.66 µM -0.199947055016944 0.423192695691027 no 1958 0.42076099441931 2729 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2151 5563267 85.4165 µM -0.200921805316006 0.42286566941115 no 1959 0.420379858603682 2805 5310824 SGTC_531 3788-1495 174 µM -0.202985599369444 0.422173447338116 no 1960 0.419573143972441 2730 2896655 SGTC_2355 9061122 103.12 µM -0.204612495097115 0.421627935665484 no 1961 0.418937446135228 2902 5302957 SGTC_2173 5763948 167 µM -0.204875773077758 0.421539670476873 no 1962 0.418834592000337 2748 2867177 SGTC_2133 5320837 200 µM -0.204881081551675 0.421537890826406 no 1963 0.418832518209451 2925 2841355 SGTC_63 0099-0242 26.702 µM -0.205106314806437 0.421462383508793 no 1964 0.418744531408885 2892 3898502 YLR359W ADE13 SGTC_39 0986-0283 58.349 µM -0.206840653334659 0.420881059862987 no 1965 0.418067152925294 2925 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2708 st078559 56 µM -0.207566260921985 0.42063789844132 no 1966 0.417783825229097 2813 17250902 SGTC_757 1066-0008 322 µM -0.208228373985703 0.42041604135519 no 1967 0.417525327441708 2934 6842497 SGTC_2010 4012422 159 µM -0.208946396283032 0.420175479094464 no 1968 0.417245042223556 2856 952393 SGTC_3163 9099914 49.47 µM -0.209330220142797 0.420046897073028 no 1969 0.417095231029679 2868 16268368 SGTC_1493 4348-0038 111 µM -0.210894182815746 0.419523053755222 no 1970 0.416484921743502 2815 800424 SGTC_1339 1486-1321 22.7 µM -0.211713648775506 0.419248633635504 no 1971 0.416165219642717 2799 3469382 SGTC_450 aminopyrene 156 nM -0.211755659959154 0.419234566122973 no 1972 0.416148831115257 2858 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2357 9067248 200 µM -0.212128529923451 0.419109714541296 no 1973 0.416003381247879 2874 9150235 SGTC_794 k038-0031 316 µM -0.212721485130374 0.418911186513694 no 1974 0.415772103786638 2767 6624242 SGTC_472 calcifediol 10 µM -0.21310676663609 0.418782201024713 no 1975 0.415621843430186 2851 5283731 A vitamin D metabolite. SGTC_2798 7813637 45.45 µM -0.21339370835661 0.418686143642229 no 1976 0.415509943749431 2922 956368 SGTC_2278 7948257 134.34 µM -0.215162238277266 0.418094213042104 no 1977 0.414820415446622 2939 1247028 SGTC_2956 9076196 2.52 µM -0.215567092131144 0.417958733666421 no 1978 0.414662604679604 2895 16423868 SGTC_2198 6589944 200 µM -0.2156232454507 0.417939943415303 no 1979 0.414640717378133 2825 5290268 SGTC_3111 9122088 49.47 µM -0.21601679516689 0.417808257475339 no 1980 0.414487327987745 2837 16876704 SGTC_2493 resveratrol 26.09 µM -0.217051675834056 0.417462019361826 no 1981 0.414084036623741 2761 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_324 1315-0088 19.6 µM -0.218492267302563 0.416980149917502 no 1982 0.41352279129342 2867 6787421 SGTC_1762 st045503 25.4615 µM -0.219558843820751 0.416623466584991 no 1983 0.413107373557296 2868 4645554 SGTC_1386 3228-0095 33.8 µM -0.220045114110793 0.416460871376859 no 1984 0.412918009834652 2935 870181 SGTC_1204 4049-0315 18.3 µM -0.221737971210501 0.415894938892956 no 1985 0.412258934537016 3057 588402 SGTC_1859 st055998 20 µM -0.222630798633593 0.415596531381718 no 1986 0.411911432060462 2936 676301 SGTC_129 0088-0017 176.636 µM -0.22432659273907 0.415029884433291 no 1987 0.411251592709239 2892 182446 SGTC_721 1187-1332 279 µM -0.225616187281094 0.414599086660658 no 1988 0.410749974908157 2751 25730 SGTC_1827 berberine 7.24 µM -0.225773717409679 0.414546469685008 no 1989 0.410688709885169 2798 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3046 9092212 49.47 µM -0.226745953755131 0.41422176490964 no 1990 0.410310645844326 2787 25236637 SGTC_1975 st070967 30.8 µM -0.22795268772595 0.413818824829644 no 1991 0.409841510952018 2931 261391 SGTC_2839 9003951 25.97 µM -0.228877603168687 0.413510048057539 no 1992 0.409482024312015 2805 2990634 SGTC_678 1218-2179 85.9 µM -0.229496049564661 0.413303613728821 no 1993 0.409241695347258 2795 6820081 YOR116C RPO31 SGTC_47 0149-0135 24.25 µM -0.229654435977596 0.413250748985009 no 1994 0.409180151691757 2787 5239155 SGTC_1980 st071811 45.7 µM -0.229889758143654 0.413172208245613 no 1995 0.409088717513418 2964 4974850 SGTC_207 4185-0010 4.486 µM -0.230258126826338 0.413049269097752 no 1996 0.408945598185436 2883 3761753 SGTC_1313 1220-0047 237 µM -0.230810288247768 0.412865007041781 no 1997 0.408731094079946 2854 3528706 SGTC_3313 9133968 57.047 µM -0.231223344418712 0.412727178415837 no 1998 0.408570647561892 2772 1494643 SGTC_1836 st055642 81 µM -0.231602381792151 0.412600710651761 no 1999 0.408423428703024 2823 8571 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.232514299923914 0.412296481684119 no 2000 0.408069290898581 2904 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2039 Aminomethylbenzodioxan 200 µM -0.233610428423304 0.411930867242919 no 2001 0.407643715517453 2815 15053 SGTC_1919 st067113 52.3 µM -0.234848063260526 0.411518145150892 no 2002 0.407163330844686 2957 1268243 SGTC_168 3970-0862 530.542 µM -0.235121879038476 0.411426847241088 no 2003 0.407057068813878 2908 3135186 SGTC_839 0122-0028 230 µM -0.236195456266653 0.411068932598347 no 2004 0.40664050258041 2836 759448 SGTC_380 3970-0968 6 µM -0.238074688079803 0.410442603073323 no 2005 0.405911583176396 2845 2891601 SGTC_559 1550-0661 158 µM -0.238461390466438 0.410313747237796 no 2006 0.40576162881326 2912 5830875 SGTC_1628 st004252 77.7 µM -0.239355673434484 0.410015793995751 no 2007 0.405414899278874 2984 692968 SGTC_144 4161-2749 112.381 µM -0.240238783700969 0.409721614199369 no 2008 0.405072574425235 2836 797501 YMR168C CEP3 SGTC_2670 beta-carotene 100 µM -0.240268237331514 0.409711803543944 no 2009 0.405061158403628 2943 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.24294285694997 0.408821155813825 no 2010 0.404024832433372 2953 16725076 SGTC_302 1094-0063 18.9 µM -0.243561667124333 0.4086151590365 no 2011 0.403785159748147 2818 5440289 SGTC_2803 7707263 71.43 µM -0.246519896289887 0.407630738829271 no 2012 0.402639902289848 2865 2199229 SGTC_1842 st055362 61.2 µM -0.247349833839228 0.40735466207595 no 2013 0.40231874741522 2854 676032 SGTC_2549 cedrol 20.94 µM -0.247493335148342 0.407306931368587 no 2014 0.402263224439964 3022 6708665 A sedative which affects the nervous system. SGTC_2514 salinomycin 42.74 µM -0.248818997525002 0.406866061170411 no 2015 0.401750397634464 3014 23682228 A polyether potassium ionophore. SGTC_470 aa-861 153 µM -0.251858236602906 0.405855759885741 no 2016 0.400575320754502 2870 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2366 9070441 60.58 µM -0.252800609361768 0.405542624103115 no 2017 0.400211148395377 2871 6837235 SGTC_52 0329-0193 875 nM -0.254483262520201 0.404983655110928 no 2018 0.399561116567128 3068 3739292 SGTC_1327 1436-0082 2.18 µM -0.254695880317252 0.404913038306358 no 2019 0.399478999184925 2893 15992205 SGTC_2822 7994718 71.43 µM -0.255641728823179 0.404598930950717 no 2020 0.399113746907071 2784 1018011 SGTC_1240 0356-0016 42.1 µM -0.255852684363102 0.40452888298534 no 2021 0.399032295586497 2905 4305613 SGTC_1223 0764-0573 147 µM -0.256542591895382 0.404299819984752 no 2022 0.398765948469072 2853 1609797 SGTC_32 0928-0142 34.1 µM -0.256948863182426 0.404164945191176 no 2023 0.398609124586723 2903 2244242 SGTC_58 0957-0393 9 µM -0.25792208825481 0.403841898246154 no 2024 0.398233518748375 2928 6997992 SGTC_1163 k060-0048 49.9 µM -0.258569934306912 0.40362689215453 no 2025 0.397983541715907 2868 6809982 SGTC_2679 rapamycin 1 nM -0.26087679132493 0.40286153309877 no 2026 0.397093761551239 2948 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2725 haloperidol 53.21 µM -0.260927549586836 0.402844696914681 no 2027 0.397074189533177 2866 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_397 arbidol 50 µM -0.26114347684774 0.402773077265565 no 2028 0.396990932443102 3009 131410 A RNA synthesis inhibitor. SGTC_440 fluspirilene 35.1 µM -0.262303389588516 0.402388408488822 no 2029 0.396543774490094 3085 3396 An atypical antipsychotic. SGTC_2145 5634607 200 µM -0.262928941295145 0.402180992248602 no 2030 0.396302674482326 2863 308662 SGTC_1750 st081859 2.357 µM -0.263644628859793 0.401943723147627 no 2031 0.396026882969808 2902 5291695 SGTC_2769 toremifene 3.73 µM -0.264499377837457 0.401660398913585 no 2032 0.395697572079653 3066 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_60 0986-0278 202 µM -0.265680363387073 0.401269021882029 no 2033 0.395242693887563 2870 3110598 SGTC_1902 st060212 70.5 µM -0.26569298225145 0.401264840541347 no 2034 0.395237834270555 2889 688944 SGTC_1976 st070609 63.5 µM -0.267012952305216 0.400827522640051 no 2035 0.394729594270767 2802 682556 SGTC_2521 angolensin 13.4 µM -0.267223099063149 0.400757910588613 no 2036 0.394648696070356 3028 821428 A flavenoid. SGTC_2786 7743617 45.45 µM -0.267383906975047 0.40070464437842 no 2037 0.394586794444616 2916 583674 SGTC_2524 avocatin b 10.57 µM -0.268069091543536 0.40047770370519 no 2038 0.394323068373658 2986 6710748 SGTC_1371 2421-0008 32.7 µM -0.269113141868314 0.400131967358107 no 2039 0.393921308813043 2916 2827552 SGTC_2563 tomatine 8.54 µM -0.269561570028719 0.399983494775639 no 2040 0.393748784418421 3004 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2383 9036125 200 µM -0.270038737018312 0.399825522770522 no 2041 0.393565226195332 2882 79580 SGTC_2635 hydroquinidine 100 µM -0.270757340232435 0.399587651274267 no 2042 0.393288836103338 2861 442912 An experimental heart treatment. SGTC_2283 7944793 200 µM -0.270977634837848 0.399514736978598 no 2043 0.393204116871594 2967 2970533 SGTC_2722 naftopidil 47.16 µM -0.271919241300493 0.399203118530654 no 2044 0.392842058037152 2965 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2104 5389443 200 µM -0.272522999756929 0.399003342429028 no 2045 0.392609954513474 3065 2244536 SGTC_1060 3448-7350 82 µM -0.272716559359013 0.398939301581197 no 2046 0.392535552263766 3014 570178 SGTC_933 2914-0560 114 µM -0.276150345492782 0.397803657829761 no 2047 0.391216296669086 3094 463887 SGTC_1960 st011366 51.8 µM -0.276695153396891 0.39762355476992 no 2048 0.391007096832684 2866 3972846 SGTC_2728 chlorpromazine 9.18 µM -0.278858315736108 0.396908670392043 no 2049 0.390176779625028 2870 2726 A thorazine and dopamine antagonist. SGTC_950 1165-0508 94.1 µM -0.280716446204785 0.396294869683993 no 2050 0.389463946760179 2985 6148369 SGTC_1302 1159-0335 255 µM -0.281786953091512 0.395941363135627 no 2051 0.389053437821095 2908 649284 SGTC_3034 9090421 49.47 µM -0.282366826456372 0.395749911022994 no 2052 0.388831124551543 2889 17173761 SGTC_3119 9125183 49.47 µM -0.282832557879274 0.395596162443936 no 2053 0.388652597651972 2953 22695334 SGTC_687 k029-0044 34.9 µM -0.283806636964477 0.395274649240955 no 2054 0.388279284009838 3041 5829338 SGTC_2290 7904846 200 µM -0.284465552822306 0.39505720201583 no 2055 0.388026814463038 2966 2962154 SGTC_2028 5153890 36.43 µM -0.287157223602212 0.39416927035582 no 2056 0.386995969082571 2913 2830968 YPR165W RHO1 SGTC_779 1360-0071 233 µM -0.287446174503622 0.394073983472839 no 2057 0.386885355032853 3103 7566 SGTC_1131 3454-3128 32.3 µM -0.287562510880526 0.394035621199226 no 2058 0.386840822593918 3063 710982 SGTC_1238 0333-0287 48.8 µM -0.288888332902213 0.39359850006989 no 2059 0.38633341612689 2927 7226 SGTC_288 1315-0019 35.1 µM -0.290583488552315 0.393039805646903 no 2060 0.385684944823066 3003 6811474 SGTC_2138 5575593 77.673 µM -0.290665005524399 0.393012944582845 no 2061 0.385653769043884 2931 762213 SGTC_840 0245-0196 390 µM -0.29158168244008 0.392710920901201 no 2062 0.385303241209489 3059 3827528 SGTC_2224 6650123 117.647 µM -0.292089936045822 0.392543491005035 no 2063 0.385108930604753 2932 2908370 SGTC_1895 st058434 18.3 µM -0.292831665304575 0.392299184796305 no 2064 0.384825411621271 3084 5393175 SGTC_1678 st019265 80.2 µM -0.296512008548209 0.391087605573743 no 2065 0.383419548793978 3156 5367020 SGTC_1160 4092-0570 10.5 µM -0.299642704327648 0.390057802644005 no 2066 0.382224853327567 2933 4994975 SGTC_222 nsc-310342 10.666 µM -0.300267313462344 0.389852437379246 no 2067 0.381986631802601 3007 432556 SGTC_1427 4048-4900 550 nM -0.300571031196187 0.389752589118255 no 2068 0.38187081213559 3057 24132586 SGTC_1287 0971-0001 34.6 µM -0.304446332189333 0.38847921124779 no 2069 0.380393936967905 2968 4665869 SGTC_787 4152-0075 138 µM -0.304804532991129 0.388361570977196 no 2070 0.380257514444022 2960 9566539 SGTC_732 3970-1727 52.7 µM -0.305898685814184 0.388002292877057 no 2071 0.379840893298833 3044 1275699 SGTC_2320 7373003 200 µM -0.306318236835696 0.387864553710957 no 2072 0.379681177591091 3006 5415828 SGTC_303 1348-1668 34.2 µM -0.308138653100061 0.387267072215386 no 2073 0.378988415142324 2975 5380509 SGTC_3323 9138564 53.9225 µM -0.30883956841799 0.387037094872685 no 2074 0.378721784120882 3121 43912313 YNL103W MET4 SGTC_3287 9117173 37.0625 µM -0.311069748004901 0.38630561474115 no 2075 0.377873799306679 3012 2789709 SGTC_1607 st000305 50.6 µM -0.311096484273697 0.386296847914962 no 2076 0.377863636891385 3097 5457690 SGTC_2439 5492030 7.2 µM -0.311425347453665 0.386189018382812 no 2077 0.377738643410657 3064 5722370 SGTC_2002 4023503 131 µM -0.311452629418689 0.386180073411512 no 2078 0.377728274725647 3089 4736863 YCR052W RSC6 SGTC_573 3702-0553 84.7 µM -0.315017264018548 0.385011854328784 no 2079 0.376374272964137 2972 1222756 SGTC_2429 5902844 64.44 µM -0.315185740058137 0.384956666285688 no 2080 0.376310315993156 3111 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1871 st057448 67.3 µM -0.315574673446403 0.384829271476828 no 2081 0.376162681849015 3163 691747 SGTC_2221 6807166 181.081 µM -0.315745765826543 0.3847732342464 no 2082 0.37609774310512 3030 674925 SGTC_23 0213-0011 39.996 µM -0.316355587419123 0.384573521308318 no 2083 0.37586631161726 3133 627608 SGTC_818 4072-2707 53.5 µM -0.319314668921131 0.383604875556938 no 2084 0.374743955141447 2908 882871 SGTC_2012 4023501 200 µM -0.322690434191115 0.382500717650493 no 2085 0.373464848667259 3060 3477460 SGTC_1926 methyl fluorone black 53.6 µM -0.322755058048119 0.382479589521495 no 2086 0.373440375675623 2989 72721 Reacts with homocysteine. SGTC_512 prima-1 270 µM -0.322993742361631 0.382401557085416 no 2087 0.373349990583797 3128 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1845 st056753 3.01 µM -0.3233262653245 0.382292854186795 no 2088 0.37322408224308 2925 5375839 SGTC_2761 levamisole 97.89 µM -0.324207795316283 0.382004723916832 no 2089 0.372890360374359 3128 26879 An alkaline phosphatase inhibitor. SGTC_3092 9117248 49.47 µM -0.326132963955212 0.381375705129698 no 2090 0.372161878832357 3023 17141857 SGTC_337 1315-0038 354 µM -0.326208684620275 0.381350970976192 no 2091 0.372133235552011 2997 1626437 SGTC_585 0kpi-0023 191 µM -0.326255354431031 0.381335726524957 no 2092 0.372115581853542 3113 64601 SGTC_2751 anetholtrithion 17.25 µM -0.327997285630597 0.380766865620547 no 2093 0.371456857477786 3111 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1624 st003710 6.25 µM -0.328840081646504 0.38049172689559 no 2094 0.371138282779438 3124 24207033 SGTC_1552 6-methylflavone 10.6 µM -0.330620933008455 0.379910550085373 no 2095 0.370465416196662 3052 689013 SGTC_3133 9127736 49.47 µM -0.330955224422794 0.379801485022226 no 2096 0.370339153554797 3175 27243420 SGTC_2499 avocadenofuran 51.48 µM -0.333861690495242 0.378853632613955 no 2097 0.369241964617338 2970 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1274 0865-0114 173 µM -0.333909400981986 0.378838079399666 no 2098 0.369223962796517 3036 870624 SGTC_2918 7977171 22.06 µM -0.334246907845754 0.378728060627231 no 2099 0.369096625021311 2966 2236483 SGTC_776 4476-4378 112 µM -0.335292947550084 0.378387140380685 no 2100 0.3687020565949 3065 2892008 SGTC_1024 4507-0395 26 µM -0.335586811603117 0.378291382634539 no 2101 0.368591235320518 3159 4201836 SGTC_2564 betulinic acid 100 µM -0.337824812416888 0.377562359360964 no 2102 0.367747605217192 3278 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_474 dl-dihydrosphingosine 5 µM -0.339023495741988 0.377172070334318 no 2103 0.367296015092775 3149 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1090 efavirenz 20.7 µM -0.340177910721402 0.376796313563659 no 2104 0.366861275992289 3048 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1408 3909-7976 48.8 µM -0.340689238412426 0.376629916014023 no 2105 0.36666877051505 3046 24152374 SGTC_3029 9088683 49.47 µM -0.340778787061125 0.37660077722392 no 2106 0.366635060543972 3141 25236615 SGTC_809 3998-0021 90 µM -0.345195569494545 0.375164448620028 no 2107 0.364973674663001 3165 715485 SGTC_536 3852-0578 10.6 µM -0.345644301693005 0.375018618266661 no 2108 0.364805023870042 3164 2869208 SGTC_1977 st070720 65.3 µM -0.346250410054932 0.374821671695168 no 2109 0.364577266601101 3118 682188 SGTC_38 0929-0051 58.268 µM -0.346777171437848 0.374650534342178 no 2110 0.364379364352432 3145 1379719 SGTC_1840 st055363 71 µM -0.347597458252055 0.374384083874436 no 2111 0.364071257705637 3056 676033 SGTC_2687 chenodiol 100 µM -0.348443754203949 0.374109247827169 no 2112 0.363753473868963 3122 5702181 A cholesterol synthesis inhibitor. SGTC_1724 st037281 8.293 µM -0.349812906609606 0.373664748784129 no 2113 0.363239556111345 2990 574124 YDL195W SEC31 SGTC_1260 0700-1617 7.75 µM -0.351657281034065 0.373066233292728 no 2114 0.362547650723765 3135 2853078 SGTC_2250 alverine citrate 130 µM -0.355028518979472 0.371973029611341 no 2115 0.361284113043372 3034 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_646 4092-0839 27.3 µM -0.355259951734402 0.37189801979354 no 2116 0.361197427501735 3178 877796 SGTC_1620 st003704 16.5 µM -0.359374226742621 0.370565353457184 no 2117 0.359657576381891 3168 2834414 SGTC_2146 5545642 200 µM -0.359549433745221 0.370508636000776 no 2118 0.359592051941495 3105 825326 SGTC_3179 9107801 49.47 µM -0.360733670847904 0.370125352373082 no 2119 0.359149275720412 3036 4818259 SGTC_3258 9138477 49.47 µM -0.36079628711025 0.370105089925874 no 2120 0.359125869289547 3079 4970355 SGTC_1256 0570-0116 285 µM -0.363002637671415 0.369391351593526 no 2121 0.358301456980465 3058 410638 SGTC_3075 9116269 49.47 µM -0.363093558397541 0.369361949036832 no 2122 0.358267498198599 3229 17015205 YNL244C SUI1 SGTC_938 3126-1755 342 µM -0.366416250398926 0.368287960023582 no 2123 0.357027247796995 3223 1777771 SGTC_982 1491-0518 27.5 µM -0.366553746534864 0.368243539444781 no 2124 0.35697595749684 3042 3091256 SGTC_1387 3342-1166 1.8 µM -0.367152223265858 0.368050211388348 no 2125 0.356752737338185 3105 3418228 SGTC_2612 dictamnine 15.46 µM -0.367231964006931 0.368024454976192 no 2126 0.35672299929667 3120 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1706 st031321 9.9705 µM -0.369609216998008 0.367256870671039 no 2127 0.355836841271963 3158 6103185 SGTC_3106 9121286 49.47 µM -0.3701980003921 0.36706684191261 no 2128 0.355617483188569 3248 15943471 SGTC_338 4055-0136 114 µM -0.371869151149629 0.366527658589835 no 2129 0.354995137222442 3046 2900563 SGTC_2712 st079126 47.7 µM -0.372235371097016 0.366409535813514 no 2130 0.354858806444769 3036 3152970 SGTC_3241 9133421 49.47 µM -0.372516912245571 0.366318734447743 no 2131 0.354754011233018 3109 17018221 SGTC_2689 tacrolimus 100 µM -0.373520583192683 0.36599509600305 no 2132 0.354380514431051 3123 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1458 k015-0034 6.33 µM -0.374084217737566 0.365813391159327 no 2133 0.354170830059071 3105 3598957 SGTC_1481 3346-2004 36 µM -0.374247153858641 0.365760869320937 no 2134 0.354110222494428 3144 2770522 SGTC_1167 k781-0610 148 µM -0.375169821554757 0.365463498394256 no 2135 0.353767086328113 3095 4525169 SGTC_640 3381-0960 37.1 µM -0.379512066589234 0.364065104031059 no 2136 0.352153822737113 3147 1745025 SGTC_2297 7971671 152.32 µM -0.380837167858855 0.363638722203456 no 2137 0.351662038931802 3250 909016 SGTC_1876 myriocin 605 nM -0.382405760097638 0.36313420980108 no 2138 0.351080209262059 3250 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2446 5162541 200 µM -0.382851203053642 0.362990983496623 no 2139 0.350915047003466 3031 1549321 SGTC_448 monastrol 171 µM -0.383210130865206 0.362875588934162 no 2140 0.35078198349752 3124 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2045 5106652 78.05 µM -0.383515035500108 0.362777572493159 no 2141 0.350668962108557 3170 673349 SGTC_1429 4049-0205 9.46 µM -0.38381242752888 0.362681979759416 no 2142 0.3505587382071 3134 22774478 SGTC_724 3910-0327 137 µM -0.384415928282057 0.362488018736176 no 2143 0.350335098369145 3160 2885483 SGTC_2172 5754775 163.918 µM -0.385973360037651 0.361987633951193 no 2144 0.349758199283193 3078 2263357 SGTC_1084 voriconazole 435 nM -0.386445208289074 0.361836081077747 no 2145 0.349583487076679 3194 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1957 st077035 62.4 µM -0.386643582165705 0.36177237186782 no 2146 0.349510044289555 3197 705593 SGTC_2373 9071805 200 µM -0.387280545497334 0.361567832378852 no 2147 0.349274263215365 3247 10149009 SGTC_2430 5571206 200 µM -0.388490522171332 0.361179397770283 no 2148 0.348826533300501 3242 1731771 SGTC_2074 5212007 75.395 µM -0.391558355915018 0.360195183885509 no 2149 0.347692281423549 3203 758611 SGTC_1904 st060225 78 µM -0.392330370129127 0.359947653992741 no 2150 0.347407063304989 3160 66595 SGTC_1418 3966-3099 2.4 µM -0.392345288310699 0.359942871373973 no 2151 0.347401552681958 3181 740335 SGTC_1396 3511-0007 98.6 µM -0.393284494761378 0.35964181541733 no 2152 0.347054684446293 3178 X1396 SGTC_916 4466-0038 42 nM -0.394496155859807 0.359253554715246 no 2153 0.346607382381436 3313 5722064 YGL116W CDC20 SGTC_740 k014-0057 261 µM -0.395232251527416 0.359017753558233 no 2154 0.346335746452946 3181 4012779 SGTC_1752 st044819 83.042 µM -0.39717732693262 0.358394926046808 no 2155 0.345618350272845 3098 441209 YML126C ERG13 SGTC_1322 1348-1070 12 µM -0.397211148942367 0.358384099315296 no 2156 0.345605880698784 3218 6758089 SGTC_1504 k297-0033 30 µM -0.397436191896788 0.358312063927415 no 2157 0.345522915626116 3040 4388117 SGTC_2479 5617353 43.85 µM -0.398110602700298 0.358096217819269 no 2158 0.345274329582137 3264 2731746 SGTC_1311 1190-0148 100 µM -0.398543724399849 0.357957620531236 no 2159 0.345114717250898 3237 1961333 SGTC_1857 st056007 79.3 µM -0.400214246742443 0.357423235257052 no 2160 0.344499361093126 3186 619834 SGTC_2955 9076254 12.21 µM -0.40204577337143 0.356837667299803 no 2161 0.343825169840285 3206 16459619 SGTC_1705 st027868 56.3335 µM -0.402090700770961 0.356823307532727 no 2162 0.343808638138196 3170 292948 SGTC_856 0433-0016 11.3 µM -0.402263193572535 0.356768176993385 no 2163 0.343745169631651 3197 3911780 SGTC_2898 9056270 58.44 µM -0.403648604541525 0.356325493465915 no 2164 0.343235569290028 3181 19154699 SGTC_2311 7694451 200 µM -0.404544554888611 0.356039311419886 no 2165 0.342906160530033 3156 2163142 SGTC_2444 5485484 36.41 µM -0.405034134905794 0.355882965339521 no 2166 0.342726209966278 3223 6790631 SGTC_1064 honokiol 6.76 µM -0.405793908954715 0.355640381508054 no 2167 0.342447017254351 3191 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_37 0566-0070 1.56 µM -0.406049249919097 0.355558868297857 no 2168 0.34235320691595 3177 1626686 SGTC_2380 9035439 200 µM -0.406282391601132 0.355484447595716 no 2169 0.342267560920052 3265 6462575 SGTC_2157 5649910 96.377 µM -0.406812955613573 0.355315107830625 no 2170 0.342072685288792 3105 2858091 SGTC_991 3996-0057 64.7 µM -0.408252285830237 0.354855861692975 no 2171 0.34154423267828 3182 715343 SGTC_829 1635-0120 117 µM -0.408332125601598 0.354830393435769 no 2172 0.341514928445408 3245 285054 SGTC_88 0180-0332 8.668 µM -0.409423608164403 0.354482284211665 no 2173 0.341114408698527 3108 3101745 SGTC_3093 9117344 49.47 µM -0.409566546694404 0.354436705466768 no 2174 0.341061970619071 3247 24824913 SGTC_1015 4130-4525 82 µM -0.40997041594336 0.354307935128124 no 2175 0.340913824727605 3135 1363237 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.410752472002972 0.354058630443447 no 2176 0.340627023435572 3106 4000243 SGTC_2314 7727897 200 µM -0.41139868863165 0.353852675990083 no 2177 0.340390107666774 3104 900724 SGTC_396 dithiazanine 1.25 µM -0.411829819516559 0.353715294875092 no 2178 0.340232081594379 3131 10578 An antihelmenthic. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.411953051281961 0.3536760302131 no 2179 0.340186917561247 3185 5379071 SGTC_2779 methotrexate 400 µM -0.412218427916614 0.353591479996547 no 2180 0.340089665690794 3227 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_280 3448-3607 3.04 µM -0.412524179310035 0.353494075150918 no 2181 0.339977630979059 3231 626179 SGTC_994 3910-0338 138 µM -0.412613038733358 0.353465768531313 no 2182 0.339945073385005 3297 3479481 SGTC_364 0083-0097 67.7 µM -0.41439816616923 0.352897279007743 no 2183 0.33929126586292 3253 5207356 SGTC_1476 4112-3294 3.34 µM -0.416726780347225 0.352156204843773 no 2184 0.338439131862879 3256 704369 SGTC_1376 2910-0861 41.3 µM -0.418402608217058 0.351623224885696 no 2185 0.337826389961161 3187 1112859 SGTC_1822 st052468 42 µM -0.418765817124021 0.351507748401678 no 2186 0.337693644527603 3191 2873678 SGTC_379 3970-0972 5.9 µM -0.418820432412753 0.351490385525851 no 2187 0.337673685501386 3194 2898042 YBL034C STU1 SGTC_296 1222-0039 74.9 µM -0.42055249192306 0.350939903292061 no 2188 0.33704094559433 3176 5984176 SGTC_1523 st012844 44.7 µM -0.422179308394363 0.350423154085294 no 2189 0.336447071660548 3284 4274103 SGTC_3215 9129942 49.47 µM -0.423498108968135 0.350004447446968 no 2190 0.335965938984057 3267 17682944 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.42573571478134 0.34929444616263 no 2191 0.335150217258082 3236 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_62 0180-0423 3.232 µM -0.426361119618783 0.349096096839987 no 2192 0.334922363956785 3175 30102 YGL099W LSG1 SGTC_2999 9069765 71.4286 µM -0.428030462979583 0.348566860748996 no 2193 0.334314470956088 3194 2097066 SGTC_155 k072-0202 43.6 µM -0.428553104702017 0.348401226847701 no 2194 0.334124239652772 3232 5857737 SGTC_1469 k284-2957 126 µM -0.429541455837067 0.348088080878484 no 2195 0.333764615781339 3202 23884841 SGTC_2200 6600604 21.907 µM -0.429916068055029 0.34796941701032 no 2196 0.333628348336195 3151 2904777 SGTC_200 k038-0079 37.545 µM -0.430731342407799 0.34771121847003 no 2197 0.333331863259877 3155 3436683 SGTC_2377 9073351 62.6 µM -0.430831746640671 0.347679425189176 no 2198 0.333295357156466 3137 7337946 YHR072W ERG7 SGTC_2152 5568786 200 µM -0.431035529839729 0.347614899963544 no 2199 0.333221268217895 3213 5399883 SGTC_2833 9001315 45.46 µM -0.431357711155437 0.347512894564493 no 2200 0.333104146855825 3096 2989378 SGTC_3316 9136639 10.545 µM -0.432354236965477 0.347197455766978 no 2201 0.332741986646189 3259 4903665 SGTC_2382 9035899 200 µM -0.432532022199397 0.347141191011532 no 2202 0.332677391827186 3166 6462679 SGTC_677 0929-0063 136 µM -0.433521898722164 0.346827980507395 no 2203 0.332317830242045 3225 1539583 SGTC_1852 st056254 31.4 µM -0.433542318301093 0.346821520573523 no 2204 0.332310414681163 3141 442583 SGTC_1550 gossypolone 36.6 µM -0.434132055924375 0.346634970518698 no 2205 0.332096274289816 3170 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2885 9057732 51.95 µM -0.434372444331296 0.346558939790313 no 2206 0.332009002267514 3309 6471414 SGTC_363 0455-0021 3.06 µM -0.435223543360221 0.346289801469303 no 2207 0.331700087537518 3146 4597466 SGTC_808 0711-0032 135 µM -0.436499262396406 0.345886533283786 no 2208 0.331237267135053 3259 4252555 SGTC_2328 6201408 200 µM -0.438551583039727 0.345238140038809 no 2209 0.330493242958152 3267 2890418 SGTC_2678 equilin 100 µM -0.438750064182588 0.345175457591486 no 2210 0.330421323396847 3281 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_570 0987-0065 62.6 µM -0.439146479542834 0.345050278135824 no 2211 0.330277701199846 3175 3104428 SGTC_1764 st044502 93.5 µM -0.439807295539266 0.34484164433279 no 2212 0.330038341626008 3287 8407 SGTC_3098 9119039 49.47 µM -0.439839472272415 0.344831486650913 no 2213 0.330026688403165 3258 17161528 SGTC_1200 1643-0193 18.4 µM -0.443394834714469 0.34370980578007 no 2214 0.328740085677483 3292 5403974 SGTC_2546 rhodinyl acetate 100 µM -0.443470181871846 0.343686049354133 no 2215 0.328712841182801 3298 6708682 SGTC_1185 1319-0113 81.3 µM -0.443532212885112 0.343666491877562 no 2216 0.328690412305707 3272 4672763 SGTC_2909 7941780 10.49 µM -0.445373648733632 0.34308610470978 no 2217 0.328024876094552 3341 1243215 SGTC_3229 9132204 49.47 µM -0.445705619999149 0.342981512713719 no 2218 0.327904952228036 3171 17682924 SGTC_1609 st001574 46.4 µM -0.446522469895369 0.34272420444274 no 2219 0.327609942619711 3182 3960012 SGTC_2455 5377712 9.75 µM -0.448041204131333 0.342245996100845 no 2220 0.327061729894411 3245 2243908 SGTC_2620 irigenin 100 µM -0.448330508469274 0.342154930636115 no 2221 0.326957342869048 3351 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2484 5809818 12.04 µM -0.452195828052681 0.340939111238149 no 2222 0.32556395670313 3216 2870548 SGTC_2304 7443016 91.4 µM -0.452436804429304 0.340863367685741 no 2223 0.325477168964967 3217 939854 SGTC_2865 9030313 51.95 µM -0.455154169062717 0.340009691873873 no 2224 0.32449916487164 3145 42562754 SGTC_1683 st010134 710 nM -0.456695839975628 0.339525731156496 no 2225 0.323944840679994 3161 3818134 SGTC_2299 7976368 114.88 µM -0.456893595458007 0.339463670958527 no 2226 0.323873763801389 3300 2979718 SGTC_3279 9140807 49.47 µM -0.457053681285324 0.33941343554908 no 2227 0.32381623077787 3255 45595718 SGTC_852 0418-0143 439 µM -0.457363478602532 0.33931622833315 no 2228 0.323704905105707 3314 5369229 SGTC_2646 retinol 96.75 µM -0.45772366013103 0.339203225162079 no 2229 0.323575493695785 3295 445354 A vitamin A analog and teratogen. SGTC_877 0771-0151 33.1 µM -0.459539240430116 0.338633826274794 no 2230 0.322923489906069 3262 6166523 SGTC_1915 st067105 30.6 µM -0.459870622094791 0.338529938723413 no 2231 0.322804544105987 3292 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1367 1812-0510 76.9 µM -0.46076356946595 0.338250062519129 no 2232 0.322484120730239 3256 1142582 YDR527W RBA50 SGTC_460 trequinsin 123 µM -0.461031796329565 0.338166009704262 no 2233 0.322387896494584 3304 5537 A vasodilator. SGTC_555 4296-0685 37 µM -0.46124248344641 0.338099993467034 no 2234 0.322312322524801 3271 2908540 YHR072W ERG7 SGTC_1867 st057372 64 µM -0.461810157207165 0.33792214460172 no 2235 0.322108733154843 3289 688837 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.461890953042342 0.337896834679491 no 2236 0.322079761036869 3275 364106 SGTC_1676 st018489 23.4 µM -0.462883770881446 0.33758588665245 no 2237 0.321723840462427 3216 3696235 SGTC_3067 9117431 49.47 µM -0.463888420613663 0.337271345742978 no 2238 0.321363844674388 3218 17150885 SGTC_1257 0669-0121 16 µM -0.464124994321969 0.337197294560297 no 2239 0.321279097688992 3267 4307855 SGTC_2000 st075254 36.4 µM -0.464304344793653 0.337141159327382 no 2240 0.321214855787438 3293 17234175 SGTC_1007 4101-0031 70 µM -0.464456422545636 0.33709356307379 no 2241 0.321160386946518 3322 1146276 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.465564612683245 0.336746808090883 no 2242 0.320763588883906 3326 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1352 1496-0991 99 µM -0.466140567895416 0.336566645285917 no 2243 0.320557443423299 3215 3000039 SGTC_3186 9110464 49.47 µM -0.46786232980866 0.336028289964253 no 2244 0.319941521869765 3340 17018021 SGTC_1736 st036774 51 µM -0.469618030470452 0.335479668949011 no 2245 0.319313970217456 3425 1272247 SGTC_1270 0831-1170 17.3 µM -0.472074089771852 0.334712788439709 no 2246 0.31843695293413 3321 6764716 SGTC_3137 9097352 49.47 µM -0.476096203127754 0.333458411773783 no 2247 0.317002920935592 3477 44120435 SGTC_2835 9006588 71.43 µM -0.476369539793366 0.333373233595027 no 2248 0.316905565668677 3388 2345538 SGTC_1301 naphtanilide LB 4.81 µM -0.476624854787989 0.333293679156042 no 2249 0.316814640692301 3366 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_371 0195-0006 7.36 µM -0.476691623289418 0.33327287577589 no 2250 0.316790864342945 3227 3928593 SGTC_138 0850-0259 40.9225 µM -0.478025943507353 0.33285724288514 no 2251 0.316315869975206 3341 6813004 SGTC_3027 9089541 49.47 µM -0.47833997398989 0.332759454064036 no 2252 0.316204124688895 3334 9943819 SGTC_1267 0828-0272 9.49 µM -0.478899591388807 0.332585217892726 no 2253 0.316005030834721 3397 745334 SGTC_1755 st041960 45.185 µM -0.479666798326283 0.332346407754208 no 2254 0.315732170021474 3351 2257073 SGTC_2805 7950783 58.44 µM -0.482277033968673 0.331534424225393 no 2255 0.314804579824467 3318 1178958 YDL195W SEC31 SGTC_34 0469-0683 81.75 µM -0.48270709833316 0.331400717021857 no 2256 0.314651861219274 3311 3690923 SGTC_419 nsc-638432 893 µM -0.484094954582674 0.330969378513149 no 2257 0.314159240917585 3282 368090 SGTC_2642 cholecalciferol 100 µM -0.484236698953948 0.330925337712082 no 2258 0.31410894728777 3329 9821465 A vitamin D precursor, similar to steriods. SGTC_1182 1222-0449 220 µM -0.489080970284936 0.329421604253363 no 2259 0.312392186679324 3315 658318 SGTC_1057 3448-5381 134 µM -0.489192343158624 0.329387064768216 no 2260 0.312352764920193 3329 5497911 SGTC_318 1488-0629 67.2 µM -0.492562259821625 0.328342659780552 no 2261 0.311160960044861 3347 3662576 SGTC_1712 st032288 53.4 µM -0.492754458127971 0.328283133977387 no 2262 0.311093046668175 3366 2883011 SGTC_2325 6158266 200 µM -0.492909944526335 0.328234981421649 no 2263 0.311038110170296 3304 3623240 SGTC_720 r052-1644 49.9 µM -0.493501794407634 0.328051717646016 no 2264 0.31082903612671 3353 1422863 YOR257W CDC31 SGTC_2201 6605497 169.863 µM -0.493988638530905 0.327900999474509 no 2265 0.310657101678973 3302 670741 SGTC_1865 st057639 52.2 µM -0.496543036343228 0.327110663678921 no 2266 0.309755665792216 3307 688818 SGTC_2076 5212012 200 µM -0.497702604325422 0.326752146445242 no 2267 0.309346836103237 3293 604802 SGTC_2036 5160441 105 µM -0.498982441739241 0.326356629738198 no 2268 0.308895876795468 3296 134534 YIL048W NEO1 SGTC_525 k781-2675 26.7 µM -0.499156780766826 0.326302767678038 no 2269 0.308834469535709 3389 3651118 YDL195W SEC31 SGTC_1794 st048918 76.9 µM -0.500040497897846 0.326029798917657 no 2270 0.308523280964705 3333 672303 SGTC_2220 6782180 200 µM -0.500412892274288 0.325914799028272 no 2271 0.308392188680645 3316 833803 SGTC_560 2332-1943 155 µM -0.501051347228447 0.325717674948821 no 2272 0.308167493158757 3354 21177716 SGTC_3272 9137413 49.47 µM -0.501129798663264 0.325693456291703 no 2273 0.308139888201868 3313 17614870 SGTC_1216 1165-0504 9.65 µM -0.501886490926504 0.32545989642826 no 2274 0.30787368421346 3401 6304004 SGTC_1442 4112-3290 3 µM -0.50238780733983 0.325305198345185 no 2275 0.307697376989147 3295 704353 SGTC_1496 4469-0713 57.4 µM -0.502453295114162 0.325284992106434 no 2276 0.307674348969147 3374 746691 SGTC_1258 0671-0043 57.1 µM -0.502616100674584 0.325234760711528 no 2277 0.307617103556397 3321 4298767 SGTC_3158 9100007 49.47 µM -0.502943094182295 0.325133880999963 no 2278 0.307502140811521 3268 19297233 SGTC_1799 st045822 46.1415 µM -0.504212779756044 0.324742295954068 no 2279 0.307055930399576 3382 3674992 SGTC_1540 guanosine 70.6 µM -0.504312869649521 0.324711435353395 no 2280 0.307020767565128 3342 6802 Guanosine is a purine nucleoside SGTC_2644 guaiazulene 100 µM -0.504823825888475 0.324553911562832 no 2281 0.306841289895252 3358 3515 A coloring agent. SGTC_2916 7875993 68.79 µM -0.505087267742973 0.324472706769875 no 2282 0.306748771814769 3417 1299250 SGTC_1150 3909-7983 10.9 µM -0.506153129981752 0.324144244641725 no 2283 0.306374577618779 3292 23965914 SGTC_113 0099-0221 2.5 µM -0.507544939119059 0.323715542892228 no 2284 0.305886256532882 3445 89219 SGTC_812 4251-0442 148 µM -0.508105751429789 0.323542868865791 no 2285 0.305689591005747 3381 5723007 SGTC_2912 7964298 10.93 µM -0.508310266993397 0.323479908005522 no 2286 0.305617885477046 3370 2975850 SGTC_3317 9138495 8.753 µM -0.510570241618861 0.322784503407103 no 2287 0.304826008943723 3376 17020139 SGTC_665 3914-0008 307 µM -0.510656712451784 0.322757908218816 no 2288 0.304795728394379 3291 1069549 SGTC_2682 pyrogallin 40.03 µM -0.513156908025525 0.321989334243998 no 2289 0.303920783225112 3334 822798 An ATP competetive kinase inhibitor. SGTC_1001 4048-4355 44.4 µM -0.515050750237009 0.321407662812177 no 2290 0.303258778334268 3338 21824233 SGTC_1746 st038117 42 µM -0.515920458692129 0.321140688621557 no 2291 0.302954982224185 3366 2898218 SGTC_697 0508-1955 564 µM -0.516067357601891 0.321095604218861 no 2292 0.302903682710565 3434 6243113 SGTC_616 4092-0450 108 µM -0.517126461897166 0.320770635059888 no 2293 0.302533941224778 3359 787165 SGTC_1849 st056239 19.2 µM -0.517221654320606 0.320741433513063 no 2294 0.302500718726139 3275 5393181 SGTC_2425 5628681 7.85 µM -0.518549972607725 0.320334069938175 no 2295 0.30203730161781 3373 5714958 SGTC_2487 5918373 44.05 µM -0.522522116559535 0.319117200674477 no 2296 0.300653425853039 3479 2876279 SGTC_1209 2323-2347 50.3 µM -0.525016054925468 0.318354174557548 no 2297 0.299786015068812 3400 5412760 SGTC_2313 7726885 200 µM -0.527161523695564 0.317698379400169 no 2298 0.299040712723051 3390 726423 SGTC_1656 st012921 11 µM -0.528510268560465 0.317286407449244 no 2299 0.298572610941247 3378 6732821 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.529430151602028 0.317005560409773 no 2300 0.298253543264514 3320 641818 YHR062C RPP1 SGTC_594 1487-1584 10.8 µM -0.530039382453296 0.316819615763713 no 2301 0.298042312912018 3306 5013332 SGTC_171 k064-0041 9.68 µM -0.532215062008348 0.31615594986294 no 2302 0.297288526092021 3320 53325 SGTC_2356 9061756 188.97 µM -0.532815566811741 0.315972876950462 no 2303 0.297080628457576 3360 20104043 SGTC_1844 rapamycin 4 nM -0.533172028920131 0.315864225459654 no 2304 0.296957251024924 3381 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2330 7979373 200 µM -0.534298768550677 0.315520894045557 no 2305 0.296567422037339 3327 1863007 SGTC_2116 5511452 16.8835 µM -0.536082926916288 0.314977564743263 no 2306 0.295950619565622 3433 870744 SGTC_1804 st050076 49.1 µM -0.537902009655274 0.314424011851873 no 2307 0.295322350466398 3426 3895976 SGTC_212 3807-4682 38.772 µM -0.537943500463887 0.314411390921093 no 2308 0.295308027662504 3423 3125501 YBL034C STU1 SGTC_3184 9108758 49.47 µM -0.53850501456737 0.314240607425838 no 2309 0.295114222047321 3397 902885 SGTC_2080 5212524 12.4 µM -0.539215074289018 0.314024700982876 no 2310 0.294869230071161 3431 260183 SGTC_3218 9131285 49.47 µM -0.539747891611547 0.313862730073681 no 2311 0.294685453643062 3501 17156417 SGTC_514 4466-0038 2.65 nM -0.540090771040162 0.313758517265278 no 2312 0.294567217494165 3361 5722064 SGTC_1727 st034309 9.9045 µM -0.541416999891852 0.313355570802332 no 2313 0.294110096196862 3501 870305 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.54164841130592 0.313285284165701 no 2314 0.294030367485067 3389 1241132 A phosphatase inhibitor. SGTC_2818 7996756 12.99 µM -0.54380754261556 0.312629817872034 no 2315 0.29328695894206 3349 2241621 SGTC_314 1671-0008 2.74 µM -0.543812326876433 0.312628366129097 no 2316 0.29328531264528 3361 3913060 SGTC_2815 7968870 71.43 µM -0.545125577499493 0.312229981471307 no 2317 0.292833576197083 3400 2977326 YHR190W ERG9 SGTC_402 epigallocatechin gallate 10 µM -0.545302607496393 0.312176294837401 no 2318 0.292772705526763 3353 65064 An antioxidant. SGTC_259 usnic acid 108.925 µM -0.549967012429447 0.310763193540151 no 2319 0.291170999775584 3510 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2240 6690706 185.951 µM -0.550099273003 0.310723165173503 no 2320 0.29112564265147 3317 805876 SGTC_921 1561-0023 372 µM -0.552199943860689 0.310087702459597 no 2321 0.290405686418888 3438 24050882 SGTC_624 k048-0052 28 µM -0.555501138207272 0.309090221437492 no 2322 0.289275965907243 3379 6835531 SGTC_358 0075-0058 9.45 µM -0.555524923500028 0.309083039622803 no 2323 0.289267833706823 3534 1069125 SGTC_370 0180-0345 38.7 µM -0.559663858163487 0.307834428227521 no 2324 0.287854369395132 3374 3989527 SGTC_1798 st045719 60.953 µM -0.562083764511543 0.307105432229414 no 2325 0.287029474727419 3429 3980186 SGTC_2873 9040596 71.43 µM -0.562442756547585 0.306997350815098 no 2326 0.286907197395106 3468 6463863 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.563130004596519 0.306790488441189 no 2327 0.286673180693694 3414 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_1893 st059353 36.1 µM -0.563768790035448 0.306598268520307 no 2328 0.286455747322297 3423 3112488 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.566632407169299 0.305737218308118 no 2329 0.285481976273898 3441 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1815 st051655 58.2 µM -0.568598123721964 0.305146775097586 no 2330 0.284814449214045 3449 5984156 SGTC_1789 tunicamycin 25 nM -0.568843343171207 0.305073153938024 no 2331 0.284731228744179 3487 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1087 pterostilbene 9.05 µM -0.5688547702094 0.3050697234408 no 2332 0.284727351017166 3507 5281727 Similar to reservatol, lowers cholesterol. SGTC_3246 9135460 32.98 µM -0.570145232674707 0.304682425522948 no 2333 0.284289599153978 3423 41446951 SGTC_727 3032-0951 202 µM -0.570609193644235 0.304543233456979 no 2334 0.284132292547346 3417 3652836 SGTC_1044 1222-0021 1.78 µM -0.571269528990479 0.30434517628307 no 2335 0.283908476749222 3439 4306703 SGTC_985 1493-0307 8.71 µM -0.573098843319321 0.30379680204488 no 2336 0.283288885185045 3506 3278274 SGTC_2557 derrustone 83.84 µM -0.573607384456037 0.303644434823039 no 2337 0.283116756791345 3494 629853 An antioxidant. SGTC_3256 9138902 49.47 µM -0.578161822347385 0.30228137471937 no 2338 0.281577435700274 3471 17228773 SGTC_2723 salbutamol 83.58 µM -0.578377623638968 0.30221685750601 no 2339 0.281504598882418 3472 9884233 β2-adrenoceptor agonist SGTC_502 l-744,832 89.3 µM -0.579255635513859 0.301954425698731 no 2340 0.281208347837802 3474 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_454 lyso-paf C-16 6.67 µM -0.579784499672975 0.301796401199807 no 2341 0.281029975827394 3435 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_691 1548-0686 185 µM -0.58071878897102 0.301517326636369 no 2342 0.280714998207446 3431 46495133 SGTC_493 zm226600 134 µM -0.581434017238118 0.301303764656562 no 2343 0.280473988236469 3536 5240098 A potassium channel opener. YCR052W RSC6 SGTC_641 4092-0595 30 µM -0.583010755139811 0.300833202915078 no 2344 0.279943030026561 3508 786260 SGTC_3099 9120367 49.47 µM -0.583310790983898 0.300743697758013 no 2345 0.279842049754816 3522 24824940 SGTC_2121 5257820 149.641 µM -0.583497628996766 0.30068796727047 no 2346 0.279779176351732 3532 791256 SGTC_2132 5317594 122.667 µM -0.585245596731781 0.300166805237404 no 2347 0.279191294855941 3444 794577 SGTC_2961 9083290 32.55 µM -0.586838917118083 0.29969210796552 no 2348 0.278655948439389 3497 17741490 SGTC_1409 3909-8004 61.9 µM -0.58734754312592 0.299540644867768 no 2349 0.278485158356472 3474 2119279 SGTC_3261 9137475 49.47 µM -0.587884230848127 0.299380862936433 no 2350 0.278305000824443 3394 17027690 SGTC_51 1013-0126 23.419 µM -0.590298672821679 0.298662517162644 no 2351 0.27749521450362 3615 1627850 SGTC_2352 9027995 87.8 µM -0.590665678234165 0.298553394212262 no 2352 0.277372224453447 3440 2997347 SGTC_593 1203-0218 61.7 µM -0.590977728791648 0.298460625441228 no 2353 0.277267671723244 3539 3666956 SGTC_1657 st012939 43.4 µM -0.592380836231059 0.298043661127276 no 2354 0.276797798048087 3521 24207257 SGTC_968 1309-0633 340 µM -0.592585443923029 0.297982879623951 no 2355 0.27672931147053 3500 3761976 SGTC_233 rapamycin 362 pM -0.595213233639046 0.297202761640754 no 2356 0.275850472725657 3509 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_810 3825-7150 143 µM -0.595914821679425 0.296994637583665 no 2357 0.275616065568134 3552 22330411 YGL099W LSG1 SGTC_3199 9111318 49.47 µM -0.596122944452982 0.296932911390634 no 2358 0.275546548634369 3462 8548020 SGTC_262 fenpropimorph 62.5 µM -0.596816603741433 0.296727224511712 no 2359 0.275314915625867 3480 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2996 9066192 71.4286 µM -0.598360215632896 0.296269740256674 no 2360 0.274799802889318 3473 6472854 SGTC_2096 5468907 200 µM -0.599032121994433 0.296070706725569 no 2361 0.274575732130106 3503 759785 SGTC_2107 5363541 170.161 µM -0.599353861486168 0.295975422101895 no 2362 0.274468468726046 3496 244052 SGTC_2968 9090663 33.37 µM -0.600340373938432 0.295683349722802 no 2363 0.274139708362669 3414 25236811 SGTC_2868 9035608 32.47 µM -0.603952190483542 0.294615147150612 no 2364 0.272937714305948 3531 6462614 SGTC_3150 9097574 49.47 µM -0.604955487828478 0.294318736044159 no 2365 0.272604286483349 3510 17217476 SGTC_2611 pyromycin 23.93 µM -0.605165379539316 0.294256743701157 no 2366 0.272534558331502 3481 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_657 3534-0529 86.7 µM -0.606002424291875 0.294009579247695 no 2367 0.272256571691761 3532 1049549 SGTC_2462 5162487 171.77 µM -0.606309911447067 0.293918807861689 no 2368 0.272154489108142 3512 2259986 SGTC_3227 9130768 49.47 µM -0.606806163012962 0.29377233984183 no 2369 0.271989778816654 3526 17720899 SGTC_2126 5251174 33.877 µM -0.606886446589348 0.293748647420307 no 2370 0.271963136646099 3582 790722 SGTC_2404 5161160 200 µM -0.608502450157992 0.293271938045259 no 2371 0.271427140712607 3525 2831543 SGTC_2895 9054447 58.44 µM -0.609280284866678 0.293042610338612 no 2372 0.271169336315374 3531 2697450 SGTC_831 k061-1017 217 µM -0.612565923683329 0.292074830023986 no 2373 0.270081697890671 3557 1240153 SGTC_1314 1222-0010 41.1 µM -0.612583168474184 0.292069754521792 no 2374 0.270075995144758 3517 3526027 SGTC_71 0417-1750 47.813 µM -0.613153816638024 0.291901824008072 no 2375 0.269887319305172 3541 6811472 SGTC_1279 0874-0590 65.2 µM -0.613389673618958 0.291832429081474 no 2376 0.269809356180289 3502 3523074 SGTC_2711 st079103 59.1 µM -0.614341593812357 0.291552428876198 no 2377 0.269494811184759 3511 54693780 SGTC_1554 st069299 38.7 µM -0.617104015006993 0.290740593426905 no 2378 0.268583060298221 3540 24207999 SGTC_1974 st069448 26.9 µM -0.618675909791996 0.290279108794223 no 2379 0.268064941559967 3515 6323587 YNR016C ACC1 SGTC_1448 4255-0083 152 µM -0.619116026993459 0.290149958518774 no 2380 0.26791996292154 3590 5399660 SGTC_1441 4106-0040 13 µM -0.61942570367636 0.290059101526936 no 2381 0.267817976257825 3551 2904180 SGTC_251 melphalan 456.522 µM -0.623285147291985 0.288927887904043 no 2382 0.266548578177724 3586 460612 A DNA alkylator. SGTC_823 0417-1665 178 µM -0.624406071915691 0.288599731238944 no 2383 0.266180469231789 3553 3429856 SGTC_1641 st009299 47.1 µM -0.624907699979581 0.288452933836703 no 2384 0.266015819186428 3524 4046054 SGTC_229 benomyl 22.8748 µM -0.625095195923081 0.288398073699869 no 2385 0.265954290391747 3561 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_1286 0929-0070 131 µM -0.625584002219365 0.288255075174964 no 2386 0.265793917297056 3604 1420408 SGTC_1245 0418-0076 17.2 µM -0.625841617668069 0.288179724160521 no 2387 0.265709415637916 3547 6790114 SGTC_2058 5236698 133 µM -0.62703562559503 0.287830605213236 no 2388 0.265317941407609 3537 766665 SGTC_2241 6772625 37.8075 µM -0.627603176852773 0.287664727564708 no 2389 0.265131963533475 3526 2285411 SGTC_1275 0867-0008 21.1 µM -0.627953521706422 0.287562355175076 no 2390 0.265017193937966 3519 3422836 SGTC_814 3342-0569 96 µM -0.629711636260668 0.287048886212528 no 2391 0.264441633972125 3608 4346283 SGTC_3268 9137683 49.47 µM -0.631817414644108 0.286434451823885 no 2392 0.26375309641328 3568 1953228 SGTC_1751 st044839 27.194 µM -0.633156099559289 0.286044168541446 no 2393 0.263315855348999 3583 5291326 SGTC_2347 9049783 174.81 µM -0.634223307518733 0.285733213414755 no 2394 0.262967549401997 3575 6467988 YPL169C MEX67 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.635849394188705 0.285259725758275 no 2395 0.262437294727607 3572 2724 A muscle relaxant with antifungal properties. SGTC_82 0054-0107 293.755 µM -0.637620291680278 0.284744497389992 no 2396 0.261860441701403 3586 3104697 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.63866997848275 0.28443930926696 no 2397 0.261518823430012 3556 521171 SGTC_351 caspofungin 25 nM -0.639099672163622 0.284314424327878 no 2398 0.261379046591947 3611 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2480 5767542 37.17 µM -0.639484703819514 0.284202542099114 no 2399 0.261253830652013 3580 2867358 SGTC_562 3772-2733 112 µM -0.640606433252638 0.283876710801343 no 2400 0.260889209388375 3591 2876874 YIL048W NEO1 SGTC_2203 7227154 166.4 µM -0.642494810681699 0.28332859373511 no 2401 0.260275978808382 3593 896304 SGTC_112 phenothiazine 287.218 µM -0.644909209981934 0.282628534601796 no 2402 0.25949301146844 3592 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.646454243624843 0.282180986171121 no 2403 0.258992610393339 3641 1377 SGTC_751 0833-0568 350 µM -0.646961763326192 0.28203404788907 no 2404 0.25882834532881 3601 6954252 SGTC_990 3985-0011 41.3 µM -0.64754386667818 0.281865561357137 no 2405 0.258640006736092 3551 5399565 YGL099W LSG1 SGTC_130 0136-0219 337.655 µM -0.649595328715126 0.281272164198633 no 2406 0.257976825632684 3564 234244 SGTC_258 haloperidol 50.781 µM -0.651266209278727 0.280789298512795 no 2407 0.257437328560869 3558 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2659 sanguinarine 24.21 µM -0.651621367445348 0.280686713477666 no 2408 0.25732273000656 3556 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_971 1315-0384 26.7 µM -0.655404445172372 0.279595123554965 no 2409 0.256103695133965 3595 6769120 SGTC_424 splitomicin 100 mM -0.657564585485204 0.278972750541503 no 2410 0.255408978629612 3574 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_321 4534-3890 65.3 µM -0.659571454019258 0.278395142242868 no 2411 0.254764439008398 3619 699746 SGTC_3013 9080133 71.4286 µM -0.659638682769968 0.278375802845458 no 2412 0.254742862114017 3686 17050193 SGTC_3060 1327-0027 12.5 µM -0.662679802717376 0.277501662687805 no 2413 0.253767823954625 3537 16000455 YPR107C YTH1 SGTC_2174 5790901 200 µM -0.663358460445084 0.277306772420113 no 2414 0.253550501723281 3617 786020 SGTC_2966 9084041 48.03 µM -0.663421903645839 0.277288556845935 no 2415 0.253530190710729 3534 17741380 SGTC_3312 9133330 71.43 µM -0.663549442298533 0.277251940196396 no 2416 0.25348936245744 3641 17617324 SGTC_479 n-linoleoylglycine 10 µM -0.664810013989644 0.276890154340494 no 2417 0.253086008414675 3603 6433346 An anti-infammatory. SGTC_2161 5662504 8.5105 µM -0.665257919769091 0.27676166043738 no 2418 0.252942770172933 3590 2859334 SGTC_3134 9127454 49.47 µM -0.666066836419383 0.276529674832633 no 2419 0.252684190428756 3699 24262820 SGTC_254 nsc-64875 3.808 µM -0.66839761787113 0.275861773960106 no 2420 0.251939907832726 3638 56993 SGTC_3172 9105863 49.47 µM -0.669752809927931 0.275473799411815 no 2421 0.251507690275483 3599 2348785 SGTC_3307 9126885 69.2785 µM -0.669947270391877 0.275418149840213 no 2422 0.251445702276596 3615 24824909 SGTC_2419 paclitaxel 166.5 µM -0.671260427287416 0.275042503039218 no 2423 0.251027319801093 3582 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_447 ml7 120 µM -0.672141809908486 0.274790512900823 no 2424 0.250746710844255 3657 4216 Selective myosin light chain kinase inhibitor. SGTC_1864 st057645 30.4 µM -0.672710026950897 0.274628118174297 no 2425 0.250565893637382 3660 688666 SGTC_2149 5554786 194.827 µM -0.673911393562375 0.274284927117663 no 2426 0.250183824030745 3663 745063 YPR165W RHO1 SGTC_758 0868-0029 16 µM -0.674361419900339 0.274156423888157 no 2427 0.250040782126414 3641 762687 SGTC_2242 6630449 61.2675 µM -0.674490759476595 0.274119496989528 no 2428 0.249999679274407 3621 691249 YDR170C SEC7 SGTC_2953 9074162 66.49 µM -0.675037155610407 0.273963526115371 no 2429 0.249826079501635 3590 16451992 SGTC_2408 sulbentine 18.36 µM -0.678113230338726 0.273086268227314 no 2430 0.248849951349259 3617 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1529 apigenin 74 µM -0.680646628770728 0.272364821825081 no 2431 0.248047557386547 3697 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_19 0279-0214 38.434 µM -0.683516432201034 0.271548721319641 no 2432 0.247140285208273 3699 3566274 YBR002C RER2 SGTC_598 3937-0236 20.2 µM -0.683727546005623 0.271488733943463 no 2433 0.247073612926554 3679 1379313 SGTC_2497 7-hydroxyflavone 100 µM -0.684726276113032 0.27120503718386 no 2434 0.246758332403727 3635 5281894 SGTC_1170 0310-0127 64.8 µM -0.685092573757789 0.27110102465352 no 2435 0.246642753061064 3640 774975 SGTC_690 glyoxal 20.3 µM -0.685249358008827 0.271056510855646 no 2436 0.246593291169629 3561 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1958 st076513 41.9 µM -0.685844500714612 0.270887572597516 no 2437 0.246405585456396 3626 732122 YGL099W LSG1 SGTC_375 3970-0961 9.27 µM -0.686316771334675 0.270753550429192 no 2438 0.246256687634564 3620 2898222 SGTC_342 k048-0088 23.3 µM -0.686342803847475 0.270746163818702 no 2439 0.246248481488223 3635 6820570 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.687643027397368 0.270377359185636 no 2440 0.245838802750236 3700 368090 SGTC_345 1362-0200 395 µM -0.68767257575045 0.270368980800105 no 2441 0.245829496810759 3638 1419823 SGTC_3276 9139060 49.47 µM -0.68878748826771 0.270052944099929 no 2442 0.245478505182519 3718 4870619 SGTC_820 1582-0060 59.9 µM -0.692048486084509 0.26912963333984 no 2443 0.244453440245546 3658 3848840 SGTC_2098 5376439 882.5 nM -0.693475589100038 0.268726065815969 no 2444 0.244005569978743 3713 2844116 SGTC_1020 4335-0961 93.3 µM -0.693759240035176 0.268645888985753 no 2445 0.243916604066601 3609 669075 SGTC_586 0957-0265 8.15 µM -0.6944913523466 0.268439005539958 no 2446 0.243687061055323 3571 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2740 felodipine 17.08 µM -0.69532237471889 0.268204268778556 no 2447 0.243426647648619 3604 3333 L-type calcium channel blocker SGTC_1546 5-methoxyflavanone 78.7 µM -0.696240351464066 0.267945090355409 no 2448 0.243139160645028 3697 147795 SGTC_471 1-acyl-paf 4 µM -0.696635576249712 0.26783354279055 no 2449 0.243015442837636 3629 16759367 SGTC_145 3737-0113 38.366 µM -0.696687628741929 0.267818853328086 no 2450 0.242999151305896 3697 6849351 SGTC_2478 5763493 32.33 µM -0.697166746629225 0.267683663030677 no 2451 0.242849223424497 3629 1365576 YLR208W SEC13 SGTC_2471 5466956 24.79 µM -0.69837248850909 0.267343597129023 no 2452 0.242472138456812 3646 724419 SGTC_1234 0326-0494 15.5 µM -0.699358473578784 0.267065673238793 no 2453 0.242164016342954 3702 1547813 SGTC_2260 7964312 200 µM -0.699531261868067 0.267016983681094 no 2454 0.242110041558207 3699 231951 SGTC_2749 bexarotene 57.39 µM -0.701087654462497 0.266578614046677 no 2455 0.241624157161025 3682 82146 An retinoic acid receptor inhibitor. SGTC_1037 k284-1091 78.7 µM -0.702889582209064 0.266071542572248 no 2456 0.241062281979016 3658 3334711 SGTC_1951 sophoraflavanone G 9.2 µM -0.703763152979159 0.265825891323253 no 2457 0.240790141988111 3701 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1291 0993-0025 5.79 µM -0.705075558802477 0.265457054266969 no 2458 0.240381607901411 3701 4353356 SGTC_1118 chelidonine 707.474 nM -0.705164576216202 0.265432046319975 no 2459 0.240353911670874 3683 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_771 0250-0039 27.3 µM -0.70562738442792 0.265302047395078 no 2460 0.24020994490844 3679 3005115 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.705689520862892 0.265284596255601 no 2461 0.240190619570679 3707 1609 A potent and irreversible inhibitor of serine proteases. SGTC_1066 ketoconazole 628 nM -0.706020093598727 0.265191764053204 no 2462 0.240087820874145 3719 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_192 3455-0609 60.9 µM -0.708025447898337 0.264628969590806 no 2463 0.239464727231956 3730 3769639 SGTC_1307 1187-1599 12.2 µM -0.709534263891181 0.264205927439749 no 2464 0.238996498233556 3695 1538471 SGTC_1358 1509-0022 2.48 µM -0.709560850046378 0.264198476297057 no 2465 0.238988252275085 3706 3258434 SGTC_1449 4112-4002 201 µM -0.710767634414971 0.263860370784271 no 2466 0.238614120017176 3668 2059539 SGTC_844 0330-0132 15.3 µM -0.711473606353479 0.263662680517556 no 2467 0.238395400387964 3688 2828079 SGTC_867 0518-0118 155 µM -0.711521964382904 0.263649141793417 no 2468 0.238380422436845 3714 6848158 SGTC_1923 st058458 19.1 µM -0.711871110478371 0.263551402415972 no 2469 0.238272296575669 3733 3534982 SGTC_1428 4049-0204 61.7 µM -0.712663609858489 0.263329620093471 no 2470 0.238026969878211 3728 X1428 SGTC_343 4130-2827 29.8 µM -0.713138755108924 0.26319669558594 no 2471 0.237879949976728 3741 1118244 SGTC_2569 tetrandrine 100 µM -0.714015581051843 0.262951488708095 no 2472 0.237608772428028 3699 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2526 patulin 37.61 µM -0.715073259606379 0.262655861359779 no 2473 0.237281888116072 3740 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1563 conessine 56.1 µM -0.716544210952094 0.262245004743589 no 2474 0.236827689312971 3767 441082 An anti-amoebic, histamine inhibitor. SGTC_1792 st045773 43.6 µM -0.717958772220921 0.261850209414965 no 2475 0.236391353884093 3632 2919270 SGTC_2134 5324836 1.464 µM -0.718018808914198 0.261833460289842 no 2476 0.236372844766659 3689 699272 SGTC_3260 9137109 49.47 µM -0.71832608963676 0.261747743265764 no 2477 0.236278123611464 3564 17478346 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.71842791314224 0.261719342421538 no 2478 0.236246740506658 3761 5393153 SGTC_3212 9128307 49.47 µM -0.718603686125085 0.261670319141347 no 2479 0.236192570775796 3686 27243542 SGTC_1032 k061-1018 98.7 µM -0.719765886275122 0.261346298850419 no 2480 0.235834576058544 3805 4005393 SGTC_1692 fluoroquinolonic acid 71 µM -0.720141864867617 0.26124152051535 no 2481 0.235718826731463 3717 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1728 st035614 33.7865 µM -0.721329763632835 0.260910616808271 no 2482 0.235353324398027 3722 15945546 SGTC_1144 3486-0183 12.5 µM -0.722985947612697 0.260449626588724 no 2483 0.234844258814718 3736 6744069 SGTC_453 enantio-paf c16 10 µM -0.7268702253714 0.259370105944175 no 2484 0.233652729209024 3693 13871343 A lipid and platelet activating factor SGTC_940 3232-1287 54.8 µM -0.727126306994448 0.259299016907868 no 2485 0.233574292310609 3668 1585493 YIL048W NEO1 SGTC_2940 9060638 45.86 µM -0.727974663419569 0.25906358253518 no 2486 0.233314548069575 3734 4027022 SGTC_438 sphingosine 6.67 µM -0.731064113982088 0.258207138876876 no 2487 0.232369996246116 3672 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2989 9073649 71.4286 µM -0.732195192502517 0.25789395379269 no 2488 0.232024719117255 3694 21367202 SGTC_377 3970-0964 33.1 µM -0.732456793978879 0.257821546860574 no 2489 0.231944902393893 3714 16481235 SGTC_1772 st048439 82.2 µM -0.732697383666829 0.257754964955883 no 2490 0.231871510036092 3739 2927068 YDL195W SEC31 SGTC_875 0709-0210 25.7 µM -0.734036607679275 0.257384505078982 no 2491 0.23146321359287 3729 6251364 SGTC_2878 9043973 25.97 µM -0.735279881319626 0.257040835074153 no 2492 0.231084529139506 3793 6465167 SGTC_1655 st012546 55.1 µM -0.735329542346898 0.257027112560072 no 2493 0.231069410242435 3686 720985 YLR208W SEC13 SGTC_1391 3442-0225 151 µM -0.735374808958881 0.257014604658652 no 2494 0.231055629670436 3692 5227075 SGTC_2025 5147754 141 µM -0.735922286702887 0.256863352725876 no 2495 0.230888996655539 3736 315777 YLR208W SEC13 SGTC_1357 1503-1303 39.5 µM -0.736016103365014 0.256837438602483 no 2496 0.230860448891563 3730 292895 SGTC_1067 clotrimazole 1.36 µM -0.736204543562314 0.256785391592041 no 2497 0.230803113793788 3755 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1157 4092-0394 27.6 µM -0.738361797293565 0.256189951484714 no 2498 0.230147311466871 3818 3659885 SGTC_520 3584-0023 682 µM -0.739896143257718 0.255766883457387 no 2499 0.229681507398216 3762 1340790 SGTC_2296 7971656 126.45 µM -0.740282849989886 0.255660313675752 no 2500 0.229564192490251 3796 666570 SGTC_1 0258-0098 57.368 µM -0.740530298346047 0.255592133296245 no 2501 0.229489141900484 3674 6790032 YDR047W HEM12 SGTC_1875 nocodazole 6 µM -0.741364010150155 0.255362487457566 no 2502 0.229236380011564 3711 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_2485 5633444 17.78 µM -0.741633942929785 0.255288157615701 no 2503 0.229154576181649 3751 5724239 SGTC_2634 4'-methoxyflavone 100 µM -0.74184746613546 0.255229368967727 no 2504 0.229089879018908 3754 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_695 3505-6186 243 µM -0.743191214706571 0.254859561560436 no 2505 0.228682960740102 3740 1819379 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.744611896203075 0.254468886979384 no 2506 0.228253187109454 3751 688761 SGTC_226 1,3-diallylurea 8.28947 mM -0.746061212237948 0.254070661747926 no 2507 0.227815219409874 3701 74537 YKL182W FAS1 SGTC_587 k089-0003 57 µM -0.746410649289415 0.253974696669664 no 2508 0.227709694095842 3673 9659696 SGTC_564 3555-0129 330 µM -0.746830449808784 0.253859432992311 no 2509 0.227582956346508 3643 563260 SGTC_2322 7413319 38.22 µM -0.746943578287419 0.253828376259676 no 2510 0.227548809661404 3809 1840400 SGTC_2122 5258151 111.688 µM -0.747170611460737 0.253766055721013 no 2511 0.227480290703883 3756 2173356 SGTC_287 k060-0039 29.6 µM -0.749189131438844 0.253212326013497 no 2512 0.226871609491554 3778 5861974 SGTC_3180 9109287 49.47 µM -0.749575278582692 0.253106468796561 no 2513 0.226755272262799 3763 18891271 SGTC_2253 7938677 135.83 µM -0.750197400207298 0.252935971221337 no 2514 0.226567912185895 3791 2301972 SGTC_1486 3970-0793 4.53 µM -0.750472621194085 0.252860563923174 no 2515 0.226485053670907 3806 2844330 SGTC_300 r073-0011 5.04 µM -0.751496072888792 0.252580254109449 no 2516 0.226177081658258 3771 2735780 SGTC_3302 9125395 16.351 µM -0.751980500591333 0.252447632903134 no 2517 0.226031392625719 3712 17599668 SGTC_670 4204-0025 119 µM -0.753029827396052 0.252160485817194 no 2518 0.225715995192869 3787 719039 SGTC_3055 9094636 49.47 µM -0.754015829810922 0.25189082444708 no 2519 0.225419858269466 3766 25236176 SGTC_1753 st043925 64 µM -0.7558759093085 0.251382526837902 no 2520 0.224861799500121 3801 670181 SGTC_3176 9106582 49.47 µM -0.755910175879214 0.251373168017101 no 2521 0.22485152623825 3652 17018027 SGTC_1116 jasmonic acid  1.58368 µM -0.7561243152095 0.25131468686138 no 2522 0.224787332394943 3780 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_368 fentichlor 4.58 µM -0.756227742101491 0.251286443696108 no 2523 0.22475633121151 3775 7329 A pesticide. SGTC_993 3909-8757 62.7 µM -0.75685057503547 0.251116399883208 no 2524 0.22456969449597 3744 4288324 YLR208W SEC13 SGTC_3230 9131665 49.47 µM -0.759334287525337 0.250438910605658 no 2525 0.223826305852085 3700 15943720 SGTC_2153 5569715 200 µM -0.759338360303498 0.250437800458538 no 2526 0.223825087997222 3772 2054701 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.761614914425465 0.249817671732522 no 2527 0.223144935355269 3766 551469 SGTC_627 1391-0720 175 µM -0.761647700554793 0.249808746816069 no 2528 0.223135148639992 3776 997839 SGTC_2922 7999257 32.47 µM -0.76209869965371 0.249685994724711 no 2529 0.223000549447449 3748 2988377 SGTC_224 benfluorex 43.875 µM -0.762500238377565 0.249576731629381 no 2530 0.222880750463976 3752 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2624 nerol 100 µM -0.763426694211161 0.249324729772658 no 2531 0.222604482521509 3710 637566 A natural product oil. SGTC_3008 9078912 71.4286 µM -0.763835450029801 0.24921358862324 no 2532 0.222482654156007 3763 16648731 SGTC_3070 9117005 49.47 µM -0.765667241912206 0.248715846195089 no 2533 0.221937161667288 3805 8779016 SGTC_317 4495-0002 170 µM -0.765813794143049 0.248676047271897 no 2534 0.221893552643987 3806 15991618 SGTC_401 neomycin 50 µM -0.767450934504982 0.248231682712104 no 2535 0.221406727434049 3776 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2817 7995342 71.43 µM -0.768177339079622 0.248034652393656 no 2536 0.221190917236055 3773 18879975 SGTC_2808 7946468 45.46 µM -0.771613362819391 0.247103795608445 no 2537 0.22017172870389 3813 2970879 SGTC_558 k064-0027 21.3 µM -0.773715239342863 0.246535296548089 no 2538 0.219549603018518 3829 5088526 SGTC_873 0591-4978 488 µM -0.774604427283994 0.246295007059538 no 2539 0.219286720206721 3816 3305145 SGTC_2663 amphotericin b 100 µM -0.775949529749167 0.245931752372397 no 2540 0.218889393170088 3791 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3010 9080089 71.4286 µM -0.777607297840491 0.245484455871087 no 2541 0.218400278714458 3792 17027233 SGTC_2972 9093619 59.92 µM -0.778044909633557 0.245366453076183 no 2542 0.218271269099005 3810 25236256 SGTC_2657 nystatin 74.44 µM -0.77826560729536 0.245306953127287 no 2543 0.218206223250582 3825 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2216 7189485 200 µM -0.779152950745595 0.245067804199392 no 2544 0.217944810783134 3786 731273 SGTC_2979 9012552 45.46 µM -0.780385965038034 0.244735701447523 no 2545 0.217581863233329 3834 17100905 SGTC_1467 k284-1082 293 µM -0.782190292996815 0.244250156863752 no 2546 0.217051374180055 3765 3334705 SGTC_78 0336-0123 156.75 µM -0.784372139911656 0.243663716286235 no 2547 0.216410890485361 3669 6765896 SGTC_1023 4482-3888 16 µM -0.785643278058424 0.243322408389852 no 2548 0.216038251215764 3790 3303168 SGTC_2402 5553605 200 µM -0.786571083983966 0.243073450381576 no 2549 0.21576649598289 3848 6758546 SGTC_2219 9098279 200 µM -0.786598579290035 0.243066074672988 no 2550 0.215758445605913 3774 902349 SGTC_1734 st037168 69.4 µM -0.78685319791079 0.24299777811985 no 2551 0.215683903848197 3871 708907 SGTC_881 0833-0569 170 µM -0.787265122582227 0.242887309225111 no 2552 0.215563341033663 3824 5418700 SGTC_1361 1608-0041 5.61 µM -0.787396897715312 0.242851975847792 no 2553 0.215524781115807 3770 X1361 SGTC_76 0433-0009 400.328 µM -0.787462999160901 0.242834252858525 no 2554 0.215505440078552 3899 2841569 SGTC_20 0481-0013 4.944 µM -0.787594623698844 0.242798964031529 no 2555 0.215466930226264 3826 182045 SGTC_1042 0350-0096 82 µM -0.788412072319022 0.242579866420699 no 2556 0.215227855809934 3819 3122515 SGTC_2448 5185112 27.17 µM -0.789055399248129 0.242407513291605 no 2557 0.215039814053713 3817 5718189 SGTC_1509 1326-1131 80 µM -0.790513770075406 0.242017048288413 no 2558 0.214613891807794 3732 768313 SGTC_1767 st044992 70.3 µM -0.791961355603585 0.241629808531913 no 2559 0.214191604761095 3862 9600693 SGTC_519 k048-0011 62.8 µM -0.797308253608617 0.240202394512079 no 2560 0.212636014018868 3900 6836379 SGTC_482 fipronil 114 µM -0.797739554967462 0.240087454443306 no 2561 0.212510822297998 3858 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_762 1165-0429 115 µM -0.801940900613675 0.238969382938101 no 2562 0.21129357271589 3783 5967793 SGTC_790 1575-0012 79.1 µM -0.802690831909304 0.238770109409035 no 2563 0.211076726660346 3923 378741 YLR208W SEC13 SGTC_1653 st012112 65 µM -0.80278196337908 0.238745899934118 no 2564 0.211050384471532 3818 720429 SGTC_2335 9018011 154.17 µM -0.803176465529343 0.238641114197885 no 2565 0.210936373094044 3876 6458208 SGTC_2387 9077560 195.08 µM -0.80467668909898 0.238242862069584 no 2566 0.210503137409868 3823 5303272 SGTC_160 3453-0671 289.699 µM -0.805220006188321 0.238098721965356 no 2567 0.210346366800664 3875 5322268 SGTC_2050 5263056 171 µM -0.8061353231175 0.237855999733142 no 2568 0.210082413134477 3870 763468 YGL055W OLE1 SGTC_1206 3978-0017 132 µM -0.806578082046607 0.237738638361822 no 2569 0.209954802802163 3928 3873677 SGTC_2561 acetosyringone 100 µM -0.809164696894862 0.237053643937397 no 2570 0.209210209199009 3858 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1560 lithocholic acid 53.1 µM -0.809229012580641 0.237036625512204 no 2571 0.209191714849746 3733 9903 A bile acid which acts as a detergent. SGTC_3136 9095672 49.47 µM -0.809753379562925 0.23689789903136 no 2572 0.209040965993023 3611 17217380 SGTC_2374 9071832 200 µM -0.809822268725759 0.236879677038532 no 2573 0.209021165988147 3766 17381698 SGTC_2788 5282734 71.43 µM -0.814370628562015 0.235678289005907 no 2574 0.207716329750159 3913 743706 SGTC_3175 9106517 49.47 µM -0.814694114613457 0.235592972707891 no 2575 0.207623711522198 3891 41468073 SGTC_2075 5212009 200 µM -0.814912799294868 0.235535306404676 no 2576 0.207561113103913 3729 780898 SGTC_563 tetrahydrosecaminediol 614 µM -0.816175387847292 0.235202519019646 no 2577 0.207199915690835 3923 334274 A psychoactive constituent of the cannabis plant. SGTC_937 3122-0005 46.7 µM -0.817641661570256 0.234816371288874 no 2578 0.206780915553661 3908 759535 SGTC_554 4483-2211 187 µM -0.817979115675536 0.234727551335078 no 2579 0.20668455623894 3901 747107 SGTC_463 ikarugamyin 104 µM -0.818189724555219 0.234672127224368 no 2580 0.206624430791543 3897 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_298 1391-0729 10 µM -0.819420264487525 0.234348441416469 no 2581 0.206273338559649 3822 3237558 SGTC_2055 5235184 200 µM -0.820629839281881 0.234030511311916 no 2582 0.205928572854376 3909 2836034 SGTC_2651 TUB2.036 5 µM -0.822481332015575 0.233544319654807 no 2583 0.205401503519031 3910 15992207 YFL037W TUB2 SGTC_2178 5812956 200 µM -0.823399078243901 0.233303532418023 no 2584 0.205140543535039 3846 5403383 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.823514430421477 0.233273277447648 no 2585 0.205107757232721 3931 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2880 9042983 58.44 µM -0.824037800429911 0.233136033496549 no 2586 0.204959040019325 3894 6464714 SGTC_2023 5144124 124 µM -0.824465251810761 0.233023975668506 no 2587 0.204837625954384 3866 2830192 SGTC_1588 farnesol 29.9 µM -0.826284466660975 0.232547397024409 no 2588 0.204321371444691 3862 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1900 st060200 72.8 µM -0.826759842400052 0.232422952490057 no 2589 0.204186597680912 3846 688945 SGTC_327 1273-0057 3.96 µM -0.827045904725128 0.232348084543626 no 2590 0.204105521680497 3769 3108138 SGTC_2692 st077426 47.7 µM -0.828306126888247 0.232018420243186 no 2591 0.203748576948764 3870 25238571 SGTC_1587 estradiol valerate 56.1 µM -0.829730879692323 0.231646029856748 no 2592 0.20334547915063 3913 13791 A steroid. SGTC_1994 st072947 40.9 µM -0.831300099422617 0.231236265620021 no 2593 0.202902059225421 3946 5286565 YDL195W SEC31 SGTC_1218 1348-1416 30.7 µM -0.832066419657391 0.231036306451133 no 2594 0.202685727481579 3828 6787668 SGTC_1241 0364-0022 50.8 µM -0.832412412382566 0.230946056746027 no 2595 0.202588099124818 3909 4563895 SGTC_2281 7943571 200 µM -0.833740478471279 0.230599823124827 no 2596 0.202213621386764 3989 1244024 SGTC_2062 5245942 200 µM -0.834759476560833 0.230334361886196 no 2597 0.201926573200073 3938 1376160 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.835760306690398 0.230073800038201 no 2598 0.201644880439615 3854 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_3300 9124615 50.48 µM -0.835824289459391 0.230057148008458 no 2599 0.20162687991511 3937 24824903 SGTC_1777 st045864 34.765 µM -0.838552632349075 0.22934770267775 no 2600 0.200860200441169 3863 4691462 SGTC_744 1594-0068 283 µM -0.839507604402881 0.229099673341026 no 2601 0.200592261864476 3896 668392 SGTC_3327 9140648 26.9345 µM -0.839826912356899 0.229016774920115 no 2602 0.200502720837398 3909 8029710 SGTC_1351 1496-0003 46.5 µM -0.840374484710045 0.228874653900847 no 2603 0.20034922530279 3930 3891978 SGTC_1115 galangin 695.678 nM -0.840570204021253 0.228823867459478 no 2604 0.200294378377269 3915 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_441 propafenone 146 µM -0.841474809038269 0.228589217230822 no 2605 0.200040995819755 3869 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_2781 5567276 71.43 µM -0.842354167537816 0.228361245427787 no 2606 0.199794869692128 3947 2853274 SGTC_2258 7960471 200 µM -0.843685634557446 0.228016308775963 no 2607 0.199422548536184 3932 2974708 SGTC_1549 4'-methoxyflavonol 74.6 µM -0.848426056729387 0.226790612753341 no 2608 0.19810036819006 3839 97141 SGTC_1346 1488-2224 62.4 µM -0.849453188711149 0.226525525641048 no 2609 0.19781458371969 3860 3722427 SGTC_1696 st025591 34.7925 µM -0.850792959147259 0.226180014361177 no 2610 0.197442186757652 3899 2787147 SGTC_3277 9138724 49.47 µM -0.851946246376866 0.225882833587862 no 2611 0.197121963652792 3835 15943418 SGTC_3042 9091578 49.47 µM -0.852195567280037 0.225818617244485 no 2612 0.197052778250874 3838 25236497 SGTC_2433 5607874 27.82 µM -0.852383852326958 0.225770128446418 no 2613 0.197000539759111 3897 2252428 SGTC_391 gliotoxin 8.33 µM -0.852604596729245 0.225713287934144 no 2614 0.196939306300695 4007 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1986 st071812 45 µM -0.852918648947905 0.225632435107867 no 2615 0.196852209552716 3850 11838594 SGTC_2875 9039966 71.43 µM -0.854011725103334 0.225351150183353 no 2616 0.196549246396373 3946 6463691 SGTC_785 1270-0111 65.3 µM -0.854412170974726 0.22524815183064 no 2617 0.196438327303367 3858 6741994 SGTC_1912 st060209 90.8 µM -0.85448350290987 0.225229807400523 no 2618 0.196418573124857 3952 688787 SGTC_1479 0549-0158 134 µM -0.854667801114114 0.225182415358447 no 2619 0.196367540414082 3940 5440202 SGTC_1553 gossypol 38.6 µM -0.855454566148989 0.224980163301614 no 2620 0.196149773281683 3771 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2789 5281112 71.43 µM -0.855704356490367 0.224915971755288 no 2621 0.196080664950518 3946 765948 SGTC_1077 5-fluorocytosine 377 nM -0.855824304762408 0.224885150934557 no 2622 0.196047484669461 3927 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_566 0958-0068 16.5 µM -0.859122223800663 0.224038685959825 no 2623 0.195136543696559 3823 6815365 SGTC_1659 st012954 42.1 µM -0.859560560341816 0.2239263161322 no 2624 0.195015661725376 3914 24207262 SGTC_775 4577-0580 57.3 µM -0.860212957176493 0.223759130167013 no 2625 0.194835831743004 4009 2006902 SGTC_2412 st077135 33.4 µM -0.8616657006534 0.223387099039825 no 2626 0.194435752641715 4024 13258915 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.864578146587245 0.222642315760831 no 2627 0.193635185676349 3970 688798 SGTC_2852 9023854 51.95 µM -0.864683805817998 0.222615322759229 no 2628 0.193606180125639 4012 19798528 SGTC_3341 9147222 25.867 µM -0.865285367464826 0.222461676003925 no 2629 0.193441090037423 3942 1939759 SGTC_886 0866-0150 153 µM -0.866537366991861 0.222142092854005 no 2630 0.193097771953298 3989 271463 SGTC_1111 tnp00062 510.699 nM -0.867425267763947 0.221915607796255 no 2631 0.192854521119233 3997 676306 SGTC_3286 9117135 37.221 µM -0.870534948295307 0.221123433297701 no 2632 0.1920040644774 3907 3438150 SGTC_462 ag-879 158 µM -0.87102885663377 0.22099776185876 no 2633 0.191869198590564 3966 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_3334 9142812 21.919 µM -0.871054218415332 0.220991309838738 no 2634 0.19186227490541 3968 45283678 SGTC_1213 1315-0166 115 µM -0.871435092603959 0.220894428671522 no 2635 0.191758315868313 4026 768401 SGTC_1390 3413-2614 145 µM -0.871715757551155 0.220823052818684 no 2636 0.191681730870667 3973 3421432 SGTC_3234 9132280 49.47 µM -0.871796374153391 0.220802553666506 no 2637 0.191659736495225 3976 17612295 SGTC_745 0469-0705 296 µM -0.872248923044334 0.220687499974257 no 2638 0.191536297691298 4018 3486736 SGTC_2729 fluphenazine 10.66 µM -0.873378772822131 0.220400402739019 no 2639 0.191228328604493 3874 3372 An atypical antipsychotic. SGTC_1945 st075991 56.6 µM -0.874117786957974 0.220212733537512 no 2640 0.191027055949328 3967 1084980 SGTC_2102 5377816 72.7585 µM -0.874473761976992 0.220122368048695 no 2641 0.190930151496368 3974 1379702 SGTC_1192 1488-0095 21.4 µM -0.875784855108562 0.219789726014624 no 2642 0.190573502420882 3986 915875 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.876651822682742 0.219569923216297 no 2643 0.190337891042283 3970 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1145 3546-0597 10.2 µM -0.881200623070013 0.218418734159681 no 2644 0.189104621058593 3922 875334 SGTC_542 3381-0244 89.3 µM -0.881810218581876 0.218264725169299 no 2645 0.188939722382368 3984 1112843 SGTC_761 k216-0224 480 µM -0.884142652896203 0.217676033984425 no 2646 0.188309605395823 3950 1340404 SGTC_1606 st000094 49.2 µM -0.884673981401231 0.217542058371593 no 2647 0.188166246261317 3933 1242210 SGTC_2068 5226020 147 µM -0.884736403649231 0.217526321593748 no 2648 0.188149408373436 3992 1810509 SGTC_2438 5259590 200 µM -0.884871651393331 0.217492227611885 no 2649 0.188112929597101 3972 1201127 SGTC_749 1000-0129 128 µM -0.885498165254253 0.217334332859666 no 2650 0.18794400436545 4012 708470 SGTC_2097 5376186 200 µM -0.886080169911304 0.217187714693411 no 2651 0.187787163971604 3905 742755 SGTC_1708 st033234 31.827 µM -0.889181693852734 0.216407345348032 no 2652 0.186952719742087 4052 674664 SGTC_537 1334-0398 209 µM -0.890463157481169 0.216085392741668 no 2653 0.186608621349543 3948 5846986 SGTC_953 1188-0045 9.7 µM -0.891798932029407 0.215750090652115 no 2654 0.186250357125354 3998 6144426 SGTC_719 2810-4230 27.3 µM -0.893701526513639 0.215273028231172 no 2655 0.185740804211397 3951 721079 SGTC_228 caffeine 993.056 µM -0.897012892485444 0.214444187634541 no 2656 0.184856018772736 3950 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2943 9068529 45.32 µM -0.897707518056786 0.214270557406933 no 2657 0.184670750157173 3960 3270634 SGTC_1452 4194-0072 190 µM -0.901226326218605 0.213392245269739 no 2658 0.183733998115564 4025 1343545 SGTC_2413 inermin 26.06 µM -0.901626777939907 0.213292423697821 no 2659 0.183627580644588 4086 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_504 lovastatin 124 µM -0.90344515164888 0.212839495907081 no 2660 0.18314484283379 3991 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1510 1123-0200 71.5 µM -0.904728152412315 0.212520259018605 no 2661 0.182804711412295 4040 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_535 2293-4129 48.2 µM -0.907639641666592 0.211796859201425 no 2662 0.182034321492137 4003 396118 YIL048W NEO1 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.908342626019322 0.211622409193436 no 2663 0.181848614123608 3973 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_1817 st052116 64.4 µM -0.910899892408991 0.210988517307166 no 2664 0.181174061188842 3983 4361398 SGTC_999 SEC7.066 22.7 µM -0.912646563579124 0.210556195242979 no 2665 0.18071422822444 3972 740511 YDR170C SEC7 SGTC_2724 maprotiline 69.64 µM -0.914915710550327 0.209995331214657 no 2666 0.18011794086093 3907 4011 A tricyclic antidepressant. SGTC_2047 4141938 200 µM -0.917906217244206 0.209257511486632 no 2667 0.179333983215981 3985 3807862 SGTC_3297 9117502 71.43 µM -0.920006039972287 0.208740354980161 no 2668 0.178784801456738 4011 7453720 SGTC_693 4161-2696 114 µM -0.92006253145604 0.208726452342849 no 2669 0.178770041471484 4024 805759 SGTC_3038 9091290 49.47 µM -0.920601673379993 0.208593796180841 no 2670 0.178629214114507 3991 25236843 SGTC_2917 7979103 53.79 µM -0.921135805053643 0.208462421819213 no 2671 0.178489764376405 4060 2980565 SGTC_308 4092-1169 104 µM -0.922359916160961 0.208161525087468 no 2672 0.178170435308781 3931 2268590 YDL196W YDL196W SGTC_1333 1482-0047 286 µM -0.924743696395251 0.207576308069215 no 2673 0.177549622064491 3992 3811116 SGTC_3222 9128301 49.47 µM -0.928922229951246 0.206552828861897 no 2674 0.176464695768766 4020 4911358 SGTC_1153 4055-0057 267 µM -0.929764158531075 0.206346971455296 no 2675 0.176246603709248 4051 882706 SGTC_18 0111-0177 500 nM -0.930565151454405 0.206151236006395 no 2676 0.176039273977542 4054 721752 SGTC_2703 st077852 53.4 µM -0.930974242356258 0.206051310574601 no 2677 0.175933444114731 4063 6281836 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.931182204768387 0.206000524238343 no 2678 0.175879660681361 4063 23847180 SGTC_2625 euphol 100 µM -0.931322829521122 0.205966186586384 no 2679 0.175843298078377 4043 6708538 A triterpene alcohol. SGTC_550 4123-0385 25.7 µM -0.932915053076505 0.205577635456541 no 2680 0.175431914782466 4035 5731123 SGTC_2899 9053889 58.44 µM -0.932958342205864 0.205567077667952 no 2681 0.175420738682403 3969 6470052 SGTC_2605 digitonin 300 nM -0.934151723741036 0.205276150541326 no 2682 0.175112817101872 4065 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1854 st056233 32.9 µM -0.934370685894341 0.205222797677119 no 2683 0.175056356766316 3900 5393174 SGTC_1718 roemerine 11.9335 µM -0.934600108183444 0.205166904909771 no 2684 0.17499721163061 3793 235224 An aporphine alkaloid with mutagenic activity. SGTC_1058 3448-5425 97.3 µM -0.935396820888496 0.204972876863959 no 2685 0.174791917334082 3882 7279705 SGTC_1780 st038448 24.544 µM -0.93868012309895 0.204174427147687 no 2686 0.173947500856767 4084 728868 YDL195W SEC31 SGTC_2930 9013230 14.89 µM -0.938785891685507 0.204148736653938 no 2687 0.17392034194596 4040 2995857 SGTC_1323 1348-1351 11.2 µM -0.942073088263486 0.203351258383289 no 2688 0.173077610802799 3970 6989654 SGTC_1959 st077091 55.8 µM -0.942167791066266 0.203328310938837 no 2689 0.173053370670925 4010 821356 YKL052C ASK1 SGTC_174 3553-0389 74.3 µM -0.944009506208019 0.202882352081551 no 2690 0.172582395248834 4089 738071 SGTC_3012 9080433 71.4286 µM -0.944973912140611 0.202649060972756 no 2691 0.172336097425867 4005 17688859 SGTC_1522 st012842 45.6 µM -0.945104246356546 0.202617545250516 no 2692 0.172302828823537 3885 3491067 YOR116C RPO31 SGTC_319 1348-1596 45.5 µM -0.94800270115111 0.201917435902152 no 2693 0.171564039545497 4138 5380505 SGTC_3336 9143619 71.43 µM -0.948067474279841 0.201901806791458 no 2694 0.171547552630426 4064 45595730 SGTC_268 camptothecin 39.6153 µM -0.949342637832599 0.201594270023699 no 2695 0.171223187267319 3989 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1717 st033143 58.0435 µM -0.950730999454932 0.201259752088558 no 2696 0.170870473763837 4093 674616 SGTC_3063 1327-0034 4 µM -0.95085009898192 0.201231071233452 no 2697 0.170840238175955 3938 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1658 st012944 20 µM -0.953005049590384 0.200712551986273 no 2698 0.170293756117011 3912 24207260 SGTC_1556 plumbagin 1.48 µM -0.953235655811564 0.200657111593986 no 2699 0.170235342218546 3939 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2867 9039098 71.43 µM -0.954645341924257 0.200318406730978 no 2700 0.16987853966227 3995 6463460 SGTC_957 1187-1561 14.1 µM -0.955231161573806 0.200177753111671 no 2701 0.169730405271106 4004 1538454 SGTC_2372 9071633 200 µM -0.95580171340618 0.200040822321873 no 2702 0.169586211265509 4065 21321366 SGTC_1896 st058441 89 µM -0.955934875376758 0.200008871940833 no 2703 0.169552568919215 4042 688759 SGTC_996 3970-0799 1.8 µM -0.956126919004726 0.199962799120413 no 2704 0.169504058116784 4055 6615648 YGL040C HEM2 SGTC_2963 9082507 9 µM -0.957768173592023 0.199569309242256 no 2705 0.169089835573 4095 16459611 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.958803609348504 0.199321303998788 no 2706 0.168828845290169 4028 140250 A respiratory chain inhibitor. SGTC_1395 3486-0190 4.35 µM -0.96200151700793 0.198556520860216 no 2707 0.168024420954576 4023 6748079 SGTC_1472 k841-0093 193 µM -0.962620827611244 0.19840861689286 no 2708 0.167868920757547 4145 X1472 SGTC_1306 1185-0270 9.02 µM -0.963611454509991 0.198172173300254 no 2709 0.167620380934346 4078 1548076 SGTC_1632 st005650 90 µM -0.963974884890542 0.19808547212534 no 2710 0.167529258814541 4078 2759605 SGTC_369 0957-0393 4.5 µM -0.964149418759403 0.198043842880401 no 2711 0.167485509656663 4088 6997992 SGTC_3025 9087895 49.47 µM -0.964481058583628 0.197964755797678 no 2712 0.167402400154626 4052 17173641 SGTC_1793 st048256 72.231 µM -0.965570144163307 0.197705172703567 no 2713 0.167129660426622 3921 672022 SGTC_1046 2001-0062 216 µM -0.975146057236595 0.195431625231299 no 2714 0.164743907630097 3975 739778 SGTC_2437 5741531 144.16 µM -0.975333903768111 0.195387185442842 no 2715 0.164697329074044 4087 2262990 SGTC_2378 9074213 121.43 µM -0.975405455668412 0.195370259668388 no 2716 0.164679589259452 4028 657714 SGTC_128 0906-2981 13.371 µM -0.976214033231873 0.195179050608871 no 2717 0.164479205215259 4026 6740226 SGTC_2217 6934799 96.0675 µM -0.97903309763883 0.19451329994937 no 2718 0.163781813069086 4031 675606 SGTC_56 0957-0365 83.25 µM -0.979449000338817 0.194415197434689 no 2719 0.16367908798954 4058 6752360 SGTC_3239 9133757 49.47 µM -0.98102264308841 0.194044281575581 no 2720 0.163290787785144 4083 17036923 SGTC_868 0527-0199 213 µM -0.981350128230424 0.193967145841032 no 2721 0.1632100553198 4017 2849450 SGTC_1159 4092-0538 61.2 µM -0.981784566456891 0.193864847254163 no 2722 0.163102996542855 4098 717301 SGTC_850 0388-0143 75.9 µM -0.982108024545439 0.193788702883151 no 2723 0.163023316292738 4027 67273 SGTC_1988 st071872 53.4 µM -0.98365769402806 0.193424152465016 no 2724 0.162641923782274 4095 16414116 SGTC_2840 9008771 71.43 µM -0.984081314314021 0.193324571207875 no 2725 0.162537766783134 4016 2992978 SGTC_1040 k898-0338 155 µM -0.984573570526771 0.193208894874908 no 2726 0.162416788560871 4088 20969351 SGTC_162 k030-0015 37.8 µM -0.985458844889651 0.193000968709392 no 2727 0.162199368637872 4165 1809920 YMR134W ERG29 SGTC_588 3970-1144 52.9 µM -0.985471975057331 0.192997885829292 no 2728 0.162196145346868 3957 1888707 SGTC_804 1595-0054 20.9 µM -0.985889174335433 0.19289994574307 no 2729 0.162093749888299 4011 761523 Stimulates phospholipase C. SGTC_428 3448-4153 16.5 µM -0.985999312205243 0.192874095269238 no 2730 0.162066725185012 4045 3834874 SGTC_2942 9052777 62.25 µM -0.987987080122944 0.192407909801245 no 2731 0.161579487863912 4135 6469503 SGTC_2696 st077691 74.316 µM -0.988469724714575 0.192294820598919 no 2732 0.161461327309937 4137 757133 SGTC_2222 6885208 172.143 µM -0.989101968092579 0.192146740194431 no 2733 0.161306627403435 4021 609514 SGTC_1983 st071813 46.9 µM -0.991571277588581 0.191569061373788 no 2734 0.160703353105002 4131 11838595 SGTC_2191 5911152 200 µM -1.00076235255864 0.189428234912117 no 2735 0.158470857244942 4094 2875902 SGTC_2640 pentamidine 10.38 µM -1.00105149621634 0.189361126033075 no 2736 0.158400956396911 4076 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1596 piperlongumine 63 µM -1.00214618567547 0.189107186378693 no 2737 0.158136497100427 4134 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_988 1497-1057 103 µM -1.00655300554411 0.188087041217982 no 2738 0.157074813734145 4040 3533044 SGTC_1713 st033146 12.748 µM -1.00850195857733 0.187636958812774 no 2739 0.156606773970686 4100 674619 SGTC_170 4197-0004 226 µM -1.00942670526036 0.187423634954227 no 2740 0.156385018165522 4130 218692 SGTC_2981 9013952 38.96 µM -1.01119369532145 0.187016436478049 no 2741 0.155961866371135 4072 2996344 SGTC_2 0422-0095 29 µM -1.01446752390686 0.186263438538844 no 2742 0.155179859164083 3999 6790840 SGTC_1644 st010134 20.9 µM -1.01469078841484 0.186212155036961 no 2743 0.155126623250401 4074 3818134 SGTC_2931 9014674 55.67 µM -1.01585301140511 0.185945335621958 no 2744 0.154849693802152 4085 2996810 SGTC_1616 st002734 56.1 µM -1.01688015840989 0.185709723958557 no 2745 0.154605221678072 4054 4026101 SGTC_2472 5377652 49.4 µM -1.01714110785945 0.18564989570015 no 2746 0.154543153535102 4181 1610903 SGTC_3347 9188721 44.724 µM -1.01821451973278 0.185403918798929 no 2747 0.154288010343496 4132 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_3032 9089427 49.47 µM -1.02002463043982 0.18498958272022 no 2748 0.153858389781829 4129 17173707 SGTC_191 3914-0123 66.505 µM -1.02035826644263 0.184913275959788 no 2749 0.153779289474666 4093 3144412 SGTC_2021 4019055 173 µM -1.0222112802589 0.18448982442886 no 2750 0.15334045650514 3981 44827708 YER133W GLC7 SGTC_709 3807-1509 243 µM -1.0226409208014 0.184391728986023 no 2751 0.153238827110256 4168 1886677 YPL242C IQG1 SGTC_3101 9120531 49.47 µM -1.02322592929804 0.18425821214597 no 2752 0.153100517953934 4134 24824904 SGTC_1011 4112-3381 17.4 µM -1.02453145197545 0.183960468932868 no 2753 0.152792161496746 4187 2877139 SGTC_2185 6113692 200 µM -1.02530756055908 0.183783608286147 no 2754 0.15260904475021 4132 874150 SGTC_2014 4013930 200 µM -1.02568568921799 0.183697478215838 no 2755 0.152519881023247 4059 64556 SGTC_349 k015-0014 24 µM -1.03141200389579 0.182396215102601 no 2756 0.151173827032839 4104 2196908 SGTC_1401 3807-4679 7.6 µM -1.03191864490409 0.182281362600835 no 2757 0.1510551153786 4070 3291456 SGTC_376 3970-0862 59.1 µM -1.0327331072927 0.182096823571973 no 2758 0.150864407779347 4167 3135186 SGTC_2078 5212016 200 µM -1.03284394593301 0.182071719037603 no 2759 0.150838467139389 3977 1899708 SGTC_2469 5655019 90.81 µM -1.03315116521504 0.182002146339171 no 2760 0.150766581158971 4176 2788239 SGTC_1483 3453-0561 55.9 µM -1.03315302161679 0.182001725990051 no 2761 0.150766146850435 4121 4546991 SGTC_746 1095-0025 46.6 µM -1.03452131428326 0.181692065610778 no 2762 0.150446258880667 4130 6749286 SGTC_186 3455-3465 67.277 µM -1.03526719272621 0.18152340364503 no 2763 0.150272073340777 4088 755278 SGTC_2432 5630864 12.22 µM -1.03621923545722 0.181308265144736 no 2764 0.150049937434263 4180 5714970 SGTC_1525 8-methoxypsoralen 92.5 µM -1.03717467989123 0.181092518536464 no 2765 0.14982722803334 4198 4114 Related to psoralen; DNA damaging agent. SGTC_83 0170-0301 39.027 µM -1.03895780341952 0.180690306084858 no 2766 0.149412180682282 4127 3089716 SGTC_1979 st071809 45.3 µM -1.03958543393178 0.180548867213889 no 2767 0.149266273547462 4227 4976333 SGTC_1813 st051246 8.6015 µM -1.0413116269526 0.180160221441188 no 2768 0.14886547112193 4059 5291959 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.04204422005298 0.179995439743905 no 2769 0.148695588888431 4125 756377 SGTC_1103 duloxetine 36.1 µM -1.04295396331904 0.179790943551309 no 2770 0.148484807457086 4220 60835 A selective serotonin reuptake inhibitor. SGTC_1079 idarubicin 2.36 µM -1.0467923422851 0.178929743292915 no 2771 0.147597681493885 4156 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2673 kobusone 100 µM -1.04832101672204 0.17858748535722 no 2772 0.147245364882435 4216 6710676 An epoxy ketone and protein crosslinker. SGTC_159 3970-0959 50 µM -1.05092940145787 0.178004441624695 no 2773 0.14664550782488 4223 6615653 SGTC_3146 9095609 49.47 µM -1.05094610191965 0.178000712496059 no 2774 0.146641672466966 4194 17173999 SGTC_189 3970-0742 2.116 µM -1.05142447556087 0.177893914997165 no 2775 0.14653183976515 4066 2891807 SGTC_1451 4152-0210 104 µM -1.05280052721433 0.177586935163065 no 2776 0.146216211648635 4186 659563 SGTC_2511 berberine 10.47 µM -1.05440103889801 0.177230301944972 no 2777 0.145849673416442 4128 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1590 st077108 57.8 µM -1.05723667600236 0.17659956399516 no 2778 0.145201792638707 4173 5489485 SGTC_1155 4088-0394 48.2 µM -1.05779612688272 0.176475291778571 no 2779 0.145074199483035 4110 2326248 SGTC_2884 9058502 51.95 µM -1.05845446766168 0.17632912376828 no 2780 0.144924149329515 4193 6471554 SGTC_1055 3448-0672 86 µM -1.05897415300168 0.176213794828171 no 2781 0.144805775580232 4160 748378 SGTC_577 r071-0003 38.6 µM -1.06077417244111 0.175814702388186 no 2782 0.144396271197223 4150 4568517 YMR134W ERG29 SGTC_2877 9040724 71.43 µM -1.06105852238888 0.175751709965884 no 2783 0.144331653042176 4151 6463895 SGTC_3131 9127911 49.47 µM -1.06112886023371 0.175736130135583 no 2784 0.144315671865959 4211 45595681 SGTC_2451 5856223 45.7 µM -1.06157498978224 0.175637332830461 no 2785 0.144214336356151 4126 2179896 SGTC_1207 2099-0101 141 µM -1.06447591640617 0.174995768893862 no 2786 0.14355657943268 4163 5837381 SGTC_1283 0922-0125 16.4 µM -1.06462279204967 0.174963325725513 no 2787 0.143523330752607 4157 3360884 SGTC_919 tnp00227 403.569 nM -1.06669919617299 0.174505079961089 no 2788 0.143053845116701 4122 1269246 A methoxyflavone. YNL221C POP1 SGTC_1861 st057647 17.4 µM -1.06768560762656 0.174287654172489 no 2789 0.142831176370432 4247 688668 SGTC_1939 st074455 53.6 µM -1.06959958077272 0.173866265594612 no 2790 0.142399791987199 4177 1644229 SGTC_1548 st061468 90.8 µM -1.07140478179273 0.173469419023369 no 2791 0.141993731854172 4158 390799 SGTC_977 1348-1378 135 µM -1.07169549211193 0.173405564626559 no 2792 0.141928413117716 4143 X977 SGTC_3281 9140613 49.47 µM -1.07215155050482 0.173305421748401 no 2793 0.141825983868753 4167 16013766 SGTC_1568 digitonin 820 nM -1.07305135307299 0.173107948008889 no 2794 0.141624037955527 4169 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_651 3253-0966 34.4 µM -1.07942405502112 0.171713477568094 no 2795 0.140199366137349 4189 781462 SGTC_620 0109-0052 432 µM -1.08014711849215 0.171555711798862 no 2796 0.140038336244043 4170 493037 SGTC_2013 4024628 200 µM -1.08176555381161 0.171202919955194 no 2797 0.139678358108806 4221 5230760 SGTC_3342 9147791 14.508 µM -1.08274701331656 0.170989204316843 no 2798 0.139460365120935 4091 1838168 SGTC_208 k072-0098 12.366 µM -1.08611051970593 0.170258086418314 no 2799 0.138715049372483 4149 5948901 SGTC_1035 k081-0041 55.2 µM -1.08742072162159 0.169973833578569 no 2800 0.13842545875522 4211 731709 SGTC_995 3931-2021 34.6 µM -1.08790799523106 0.169868195536983 no 2801 0.138317863087721 4185 730143 SGTC_2572 astragaloside iv 100 µM -1.08839396865761 0.169762881303817 no 2802 0.138210611309975 4223 45006101 An anti-inflammatory agent. SGTC_1889 st059080 5.18 µM -1.08879471496336 0.169676067961173 no 2803 0.138122211376188 4148 176925 Isolated from Daphnopsis sellowiana. SGTC_2844 9010103 25.97 µM -1.09265977960246 0.168840244307445 no 2804 0.137271602595264 4208 2480525 SGTC_1572 epiandrosterone 68.9 µM -1.0926855376307 0.16883468299945 no 2805 0.137265945893175 4113 441302 A steroid. SGTC_3308 9128332 17.569 µM -1.09391241052457 0.168569930328012 no 2806 0.136996697592673 4187 17332805 YDL196W YDL196W SGTC_1884 5633444 25 µM -1.09801729207523 0.167686060193024 no 2807 0.136098469266329 4180 5724239 SGTC_1465 k213-0056 144 µM -1.09895005690108 0.167485632579536 no 2808 0.135894925430843 4073 24048857 YMR208W ERG12 SGTC_350 k064-0020 19.8 µM -1.10047439606931 0.167158422932818 no 2809 0.135562739694486 4230 2790705 SGTC_2175 5807670 165.306 µM -1.10056518629726 0.167138947213047 no 2810 0.135542972154069 4167 241186 SGTC_1237 0330-0133 46.1 µM -1.10248089057194 0.166728344122227 no 2811 0.135126330879482 4136 X1237 YHR072W ERG7 SGTC_1700 st030840 7.9285 µM -1.10699506990679 0.165763372313306 no 2812 0.134148029935234 4248 5499307 SGTC_606 k015-0008 38.6 µM -1.11453076138554 0.164160569683758 no 2813 0.132525777639997 4290 1970475 SGTC_637 1181-0519 7.26 µM -1.11943510357276 0.16312285927685 no 2814 0.131477281119682 4202 6252091 YGR060W ERG25 SGTC_3237 9133362 49.47 µM -1.11945021037112 0.163119669427959 no 2815 0.131474060317669 4193 43845137 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -1.11987671938221 0.163029627413119 no 2816 0.131383150152212 4247 688664 SGTC_1100 amiodarone 5.07 µM -1.1220442528086 0.162572530231529 no 2817 0.130921812392834 4297 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_265 mycophenolic acid 32.932 µM -1.12375948103574 0.162211408358768 no 2818 0.130557537557375 4283 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1380 2291-0730 164 µM -1.12582881579104 0.161776429058861 no 2819 0.130118992291096 4225 2999191 SGTC_1138 3761-0006 1.03 µM -1.12587413862714 0.161766910600395 no 2820 0.130109398638365 4254 12061087 SGTC_1561 5-methoxyflavone 52.9 µM -1.12736802171336 0.161453377574679 no 2821 0.129793456822451 4160 94525 SGTC_389 tpck 16.7 µM -1.13001581198705 0.16089863918777 no 2822 0.129234780912563 4240 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_703 3875-0075 71.8 µM -1.13017381486461 0.160865575399794 no 2823 0.129201495555625 4278 2850814 SGTC_802 4112-3352 742 µM -1.13213068432089 0.160456447271531 no 2824 0.12878974815146 4283 704594 SGTC_2594 a-mangostin 100 µM -1.13278561782591 0.160319670481177 no 2825 0.128652146290296 4253 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_3247 9135149 49.47 µM -1.13314399303125 0.160244859406358 no 2826 0.128576894677168 4249 8934436 YOR116C RPO31 SGTC_2119 5528445 120.635 µM -1.13440507776109 0.159981788537607 no 2827 0.128312335048937 4239 791935 SGTC_1972 st070201 17.4 µM -1.13630919598127 0.159585111982591 no 2828 0.127913591729501 4240 2829099 SGTC_3139 9095020 49.47 µM -1.13700398573876 0.159440529929905 no 2829 0.127768309732231 4013 25236292 SGTC_2164 5685496 200 µM -1.13916451638188 0.158991483112886 no 2830 0.127317271196209 4156 759046 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -1.13975862738166 0.158868147906994 no 2831 0.127193437277264 4240 5024745 SGTC_1600 coumarin 106 71.1 µM -1.14007628740479 0.158802228616765 no 2832 0.127127259993105 4296 100336 A hepatotoxic, DNA x-linker. SGTC_2208 7283366 200 µM -1.14241829631313 0.158316779567285 no 2833 0.126640094837956 4216 898663 SGTC_827 3253-0474 693 µM -1.14248661431045 0.158302633318337 no 2834 0.126625903441518 4261 5402065 SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.14666171718634 0.157439690824341 no 2835 0.125760729167534 4301 165506 SGTC_1524 corynanthine 62.1 µM -1.14774754489916 0.15721577111831 no 2836 0.125536398738694 4342 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_848 0368-0089 85.6 µM -1.15043965383302 0.156661507263276 no 2837 0.124981417855075 4244 762535 SGTC_2259 7964009 200 µM -1.15406688361247 0.155916752859604 no 2838 0.124236374554291 4271 313134 SGTC_2346 9031566 143.75 µM -1.15522117847166 0.155680239689899 no 2839 0.123999932068083 4221 4771086 SGTC_649 1123-0311 367 µM -1.15566320177864 0.155589732506361 no 2840 0.123909472702247 4143 693629 YIL048W NEO1 SGTC_590 k048-0076 22.4 µM -1.15596927184719 0.155527082984683 no 2841 0.123846863019702 4264 6832814 SGTC_1795 st049545 62.3 µM -1.15849750877763 0.155010214411689 no 2842 0.123330533858886 4203 5291882 SGTC_1085 doxorubicin 7.67 µM -1.16011301496278 0.154680537658651 no 2843 0.123001397946509 4267 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2101 5377231 179.231 µM -1.16141775088065 0.154414618315342 no 2844 0.122736026828436 4284 2844213 SGTC_2568 diosmetin 100 µM -1.1620581004642 0.154284218752222 no 2845 0.122605932704296 4295 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2799 7812892 81.82 µM -1.16230521174593 0.154233916962732 no 2846 0.12255575518341 4280 20205235 SGTC_1088 bifonazole 369 nM -1.16251658334386 0.154190898924461 no 2847 0.122512846267595 4218 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2721 ifenprodil 61.44 µM -1.16330505302997 0.154030500748384 no 2848 0.122352878130691 4260 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2503 beta-caryophyllene alcohol 24.72 µM -1.1645008649845 0.153787447793085 no 2849 0.122110546507361 4283 61125 An anti-inflammatory. SGTC_1883 5-benzylidenerhodanine 20 µM -1.1647063688258 0.153745703996451 no 2850 0.122068935056045 4233 1273210 SGTC_316 k060-0003 58.6 µM -1.16578282090312 0.153527167885126 no 2851 0.121851132314072 4292 6152314 SGTC_2804 7954240 19.48 µM -1.16982833481003 0.152707707324217 no 2852 0.121035029250906 4282 828705 SGTC_2882 9058044 58.44 µM -1.17245654599946 0.152176893556577 no 2853 0.120506904248044 4297 18076804 SGTC_1790 st045711 43.5 µM -1.17344992821139 0.15197658186327 no 2854 0.120307712617228 4265 585119 SGTC_3014 9081533 49.47 µM -1.17350917806229 0.151964639896514 no 2855 0.120295839252899 4310 21367265 SGTC_1290 0986-0249 10.2 µM -1.17516483402934 0.151631190055585 no 2856 0.119964388124803 4114 53329 SGTC_2718 lomofungin 53.02 µM -1.175998114618 0.151463551097309 no 2857 0.119797814733145 4238 5351222 A RNA synthesis inhibitor. SGTC_394 menadione 8.33 µM -1.17782411683384 0.151096627965823 no 2858 0.119433365994154 4257 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1925 st057770 10.1 µM -1.18127945532893 0.150403920187644 no 2859 0.118745863018754 4251 5989122 SGTC_1608 st001473 40.5 µM -1.18412702702836 0.149834647059298 no 2860 0.118181391460721 4216 7292267 SGTC_1519 esterone 74 µM -1.18427246199435 0.149805611010739 no 2861 0.118152613035928 4232 698 A steroid. SGTC_451 chloral hydrate 100 µM -1.18539410010148 0.149581802388566 no 2862 0.11793083167688 4292 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.18631485324583 0.14939824465354 no 2863 0.117748991521955 4295 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1634 st006576 41 µM -1.18697415772235 0.149266900720268 no 2864 0.117618907008999 4248 3915356 SGTC_2067 5224629 34.075 µM -1.18748597034188 0.149164992684126 no 2865 0.117517993637652 4276 2835000 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.18828052582446 0.149006879229338 no 2866 0.117361453728357 4149 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_40 0327-0103 19.753 µM -1.19098777036892 0.148468988993976 no 2867 0.11682919297147 4129 409036 SGTC_173 1273-0061 2.693 µM -1.19381629321085 0.147908391208086 no 2868 0.116274918391825 4249 2847414 YPL266W DIM1 SGTC_2851 9015922 71.43 µM -1.19742869989719 0.14719449499301 no 2869 0.115569751412753 4304 2996893 SGTC_2819 7996655 46.38 µM -1.19789657645314 0.147102200864873 no 2870 0.115478641367437 4237 6456960 SGTC_1618 st003135 44.5 µM -1.20117348938656 0.146456879093399 no 2871 0.114841955369656 4259 1270615 SGTC_714 4296-0578 26.1 µM -1.2075929415286 0.145198213227049 no 2872 0.113601937793936 4347 1589775 SGTC_890 0929-0006 47.2 µM -1.210434120255 0.144643472106087 no 2873 0.113056177939088 4283 1378169 SGTC_2465 5809242 33.21 µM -1.21585169321149 0.143589650311303 no 2874 0.112020711378065 4343 2731748 SGTC_869 0564-0080 44.1 µM -1.21888038700407 0.143002775208665 no 2875 0.111444797387733 4307 6843321 SGTC_2482 5981709 142.65 µM -1.21898800146905 0.142981952432615 no 2876 0.111424373273894 4227 877755 SGTC_669 0108-0021 26.2 µM -1.2201231435805 0.142762433792654 no 2877 0.11120909817798 4297 17201 SGTC_3160 9100216 49.47 µM -1.22456404229468 0.141905823768359 no 2878 0.110369761432461 4268 17191039 SGTC_2159 5658611 73.75 µM -1.22802981938162 0.141239728683437 no 2879 0.109717887106571 4295 793844 SGTC_2079 5212404 121 µM -1.2318033598266 0.140516897872267 no 2880 0.109011273979801 4271 758462 SGTC_3250 9135583 49.47 µM -1.23230143933291 0.140421677483872 no 2881 0.10891825117928 4347 7699353 SGTC_1034 k072-0165 12.7 µM -1.23288892628589 0.140309420945958 no 2882 0.108808603745594 4336 5835461 SGTC_3084 9116877 49.47 µM -1.23690557800139 0.139543555283931 no 2883 0.108061069486347 4257 27241325 SGTC_862 0452-0056 10.2 µM -1.23866000183497 0.139209928398005 no 2884 0.107735718616481 4278 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2280 7785178 200 µM -1.23908280109908 0.139129608764763 no 2885 0.107657417817303 4307 2954328 SGTC_2529 gangaleoidin 93.61 µM -1.24048676059305 0.138863123358258 no 2886 0.107397704059448 4330 4565183 SGTC_65 0798-0905 34.986 µM -1.2413757966564 0.138694555364377 no 2887 0.107233477971035 4374 3602145 SGTC_2225 6654152 15.4 µM -1.24345663723082 0.138300557275474 no 2888 0.106849805307562 4230 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.2447723944948 0.138051818494557 no 2889 0.106607713097466 4229 6708630 An antioxidant. SGTC_248 streptozotocin 5.23457 mM -1.24635040155953 0.137753905012695 no 2890 0.106317890818409 4354 5300 DNA alkylating agent. SGTC_1905 st060207 84.5 µM -1.24973594364992 0.137116226358691 no 2891 0.105698011277595 4310 1948547 SGTC_3191 9110352 49.47 µM -1.25014208096815 0.13703986467163 no 2892 0.105623825012384 4278 17122424 SGTC_763 3453-1109 128 µM -1.25049039025239 0.136974398925849 no 2893 0.105560231786208 4356 1560353 SGTC_654 1124-0271 80.9 µM -1.25168352800159 0.136750307213972 no 2894 0.105342602282942 4304 5403748 SGTC_101 0490-5701 117.494 µM -1.25369265356975 0.136373525640555 no 2895 0.104976869596436 4178 4661669 SGTC_1917 st066507 28.5 µM -1.25397432802197 0.13632075861153 no 2896 0.104925668331542 4281 3156428 SGTC_2060 5238662 140 µM -1.25563544318125 0.136009860397162 no 2897 0.104624087426816 4299 790130 SGTC_2720 fluspirilene 36.88 µM -1.25896419906335 0.135388304520208 no 2898 0.104021631676604 4320 3396 An atypical antipsychotic. SGTC_2115 tiliquinol 12.7705 µM -1.25922351318716 0.135339966429602 no 2899 0.103974805472675 4319 71208 A bioactive hydroxyquinoline. SGTC_2683 piperine 63.03 µM -1.26005242384987 0.135185530636304 no 2900 0.103825225682811 4340 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1081 sertraline 6 µM -1.2610180589199 0.13500577389661 no 2901 0.103651170406131 4316 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1199 1638-0010 4.46 µM -1.26276972497941 0.134680112988094 no 2902 0.103335973956744 4304 3111136 SGTC_2294 7971431 200 µM -1.26337651819244 0.134567426882852 no 2903 0.103226949450679 4332 5741572 SGTC_3065 9113888 49.47 µM -1.26490790657014 0.134283324264417 no 2904 0.102952171368499 4378 16648368 SGTC_3294 9122953 26.2835 µM -1.26613341941637 0.134056264495335 no 2905 0.102732659804267 4314 16459826 SGTC_842 0271-0008 11.1 µM -1.26776839322643 0.133753751804582 no 2906 0.102440336235911 4375 1221709 SGTC_2137 5261020 140 µM -1.2679178956451 0.133726113403896 no 2907 0.102413636306569 4314 763655 SGTC_1264 0783-0040 158 µM -1.26852034589069 0.133614778666662 no 2908 0.102306094820625 4249 2855798 SGTC_2641 levomentholum 100 µM -1.26880113836246 0.133562909099942 no 2909 0.102255999515614 4337 16666 SGTC_3203 9113543 49.47 µM -1.2705556622671 0.133239117154958 no 2910 0.101943384408263 4377 17018012 SGTC_154 3389-1638 511.116 µM -1.27375008599993 0.132650984009742 no 2911 0.101375999883892 4346 5238686 SGTC_3322 9139058 2.11 µM -1.27378528490276 0.132644513430551 no 2912 0.101369760794 4383 4908926 YPR165W RHO1 SGTC_707 0865-0008 204 µM -1.27502035768364 0.132417608882828 no 2913 0.101151018256535 4386 723043 SGTC_2492 derrusnin 100 µM -1.27863183218456 0.131755652845706 no 2914 0.100513367463018 4374 1715307 Part of coumarin class of compounds. SGTC_2442 5158906 48.48 µM -1.2805272798415 0.131409146728144 no 2915 0.100179878436001 4357 1893835 SGTC_754 3474-0146 171 µM -1.28524526330599 0.130549387622378 no 2916 0.0993532955249778 4340 24762078 SGTC_524 r073-0010 27.8 µM -1.28529482997573 0.1305403757734 no 2917 0.0993446380721618 4278 2772106 SGTC_780 0109-0199 192 µM -1.28814607781512 0.130022706746499 no 2918 0.0988475590849449 4411 610414 SGTC_2303 7774051 200 µM -1.29010155514093 0.129668495194466 no 2919 0.0985077000038988 4367 2953184 SGTC_3109 9122853 49.47 µM -1.2909031286664 0.129523492954302 no 2920 0.0983686351999339 4384 1234709 SGTC_2710 st078562 53.7235 µM -1.29095485212722 0.129514140195597 no 2921 0.0983596666491183 4295 17250908 SGTC_1423 4048-0112 5.59 µM -1.29316627884671 0.129114702371925 no 2922 0.0979767778859498 4419 X1423 SGTC_2910 7948405 25.97 µM -1.29334631888739 0.129082220370958 no 2923 0.0979456537119963 4300 2971328 SGTC_2214 7179297 48.276 µM -1.29438227522648 0.128895427963121 no 2924 0.0977667049774678 4427 769744 SGTC_1080 nisoldipine 24.4 µM -1.29451686332639 0.128871174264767 no 2925 0.0977434741393296 4364 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1056 3448-1962 115 µM -1.29604268836771 0.12859643149322 no 2926 0.0974803891226881 4332 715507 SGTC_747 3448-8087 38.7 µM -1.29694669293454 0.128433846711323 no 2927 0.0973247645283255 4426 5168703 SGTC_935 2996-0153 430 µM -1.30054816072408 0.127787541364297 no 2928 0.0967065805212245 4374 23738523 SGTC_3264 9137442 49.47 µM -1.30078278040407 0.127745515995599 no 2929 0.0966664088538534 4348 17015726 SGTC_2081 5214970 32.255 µM -1.30215064669295 0.127500693351471 no 2930 0.096432446301704 4312 2063512 SGTC_182 3448-4371 550.524 µM -1.3024949505539 0.127439120790262 no 2931 0.0963736214908905 4254 3491403 SGTC_1819 st053448 58.6 µM -1.30250240562991 0.127437787812583 no 2932 0.096372348072147 4275 2857616 SGTC_1829 berberine 14.4 µM -1.30265347904298 0.127410777771005 no 2933 0.0963465455378033 4329 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3049 9092223 49.47 µM -1.3046872768837 0.127047547639215 no 2934 0.0959996778022162 4352 8623917 SGTC_3224 9130643 49.47 µM -1.30480034405971 0.127027375351247 no 2935 0.095980420980328 4419 17644395 SGTC_1672 st016598 6.51 µM -1.30848129928772 0.126371874279922 no 2936 0.0953550567065544 4340 4665860 YNL267W PIK1 SGTC_10 0279-0212 42.575 µM -1.31196920676103 0.125752929191548 no 2937 0.0947652623188293 4365 39851 YBR002C RER2 SGTC_1312 1218-2183 165 µM -1.31543658508761 0.125139726245128 no 2938 0.0941816083763668 4432 6744073 SGTC_374 0880-0231 82.3 µM -1.31650364103766 0.124951439180449 no 2939 0.0940025285759296 4243 6833587 SGTC_1133 3473-0247 50 µM -1.31702584741632 0.124859365560336 no 2940 0.0939149803626541 4341 711311 SGTC_2671 danthron 100 µM -1.31810141862533 0.124669873965977 no 2941 0.0937348498433447 4367 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_169 k015-0017 16.025 µM -1.32165927611273 0.124044491535254 no 2942 0.0931408175963256 4369 1840002 SGTC_1052 3253-3998 198 µM -1.32430757923214 0.123580413391388 no 2943 0.0927004571918626 4318 5450317 SGTC_2941 9056145 11.23 µM -1.32447836602276 0.123550527181408 no 2944 0.092672111670677 4301 2119517 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.32691738013058 0.123124273085655 no 2945 0.0922680072095558 4339 6708739 YPR165W RHO1 SGTC_3329 9141233 27.5565 µM -1.32851428918668 0.122845748381596 no 2946 0.0920041331139173 4349 4909101 YNL103W MET4 SGTC_131 0141-0277 33.849 µM -1.32945409553048 0.122682038847291 no 2947 0.0918491004483942 4354 1547771 SGTC_1955 wogonin 32.4 µM -1.33275925373945 0.122107512641336 no 2948 0.0913054106018656 4410 5281703 A flavanone. SGTC_1130 3454-2858 15.9 µM -1.33391562079246 0.121906951490627 no 2949 0.0911157557847086 4367 715628 YIL048W NEO1 SGTC_2934 9036370 36.88 µM -1.33437724054966 0.121826952480963 no 2950 0.091040127553639 4367 6462800 SGTC_545 4218-0007 221 µM -1.33443073210015 0.121817684744891 no 2951 0.0910313669205375 4379 2840508 SGTC_2832 7992762 51.95 µM -1.33636543477559 0.121482818636363 no 2952 0.090714929181261 4329 2985177 SGTC_2709 st078560 56 µM -1.33639530621897 0.121477653444665 no 2953 0.090710049850005 4373 17250903 SGTC_647 0140-0236 81 µM -1.33783998802813 0.121228031953709 no 2954 0.0904743016917479 4406 990837 SGTC_2291 7917025 104.35 µM -1.33899387906229 0.121028914481227 no 2955 0.0902863327802412 4287 2964612 SGTC_1814 st052110 31.539 µM -1.33941797493628 0.120955789606215 no 2956 0.0902173204793235 4326 674163 SGTC_650 1328-0195 38 µM -1.34315086004313 0.120313486548242 no 2957 0.0896115648291858 4408 2780821 SGTC_1330 1469-0054 61.8 µM -1.34616633167305 0.119796383362218 no 2958 0.0891244402362445 4383 7102664 SGTC_295 k015-0027 31 µM -1.34681430347034 0.119685471840957 no 2959 0.0890200234379126 4466 3887424 SGTC_339 3091-4833 71.4 µM -1.35105741070488 0.118960980693149 no 2960 0.0883385214101658 4240 3240077 SGTC_1230 0170-0365 3.77 µM -1.35295430275093 0.118638098777791 no 2961 0.0880351148365434 4440 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1375 2910-0797 186 µM -1.35379236011311 0.118495645163474 no 2962 0.0879013158794105 4393 742508 SGTC_1494 4358-1428 177 µM -1.35636688178587 0.11805878231491 no 2963 0.0874912325646133 4423 1564571 SGTC_768 0384-0033 77.3 µM -1.35656439063045 0.118025314743798 no 2964 0.0874598313892844 4360 3965305 YMR134W ERG29 SGTC_1739 st037196 92.5 µM -1.36096714186429 0.117281016874722 no 2965 0.0867620367464924 4440 612214 SGTC_1349 flufenamic acid 69 µM -1.36117376331968 0.117246168774038 no 2966 0.0867293916885011 4341 3371 A non-steroidal anti-inflammatory. SGTC_1766 st045414 44.774 µM -1.36243064505599 0.117034345204249 no 2967 0.086531008982948 4414 253960 SGTC_1308 1187-1617 41.4 µM -1.36259318903017 0.117006971316315 no 2968 0.0865053782873192 4440 2882570 SGTC_872 0588-0139 234 µM -1.36478732786873 0.116637902255171 no 2969 0.0861599514027957 4377 2047100 SGTC_2995 9067767 71.4286 µM -1.36483961353283 0.116629117532637 no 2970 0.0861517325898635 4425 11673567 SGTC_3198 9112019 49.47 µM -1.36554551684398 0.116510561831843 no 2971 0.0860408286533523 4466 45595555 SGTC_94 0334-0113 514.748 µM -1.37083111086245 0.115625567706417 no 2972 0.0852138051292259 4421 6795178 SGTC_3081 9117243 49.47 µM -1.37139515040657 0.115531410419435 no 2973 0.0851259042126012 4385 45595589 SGTC_515 4092-1064 102 µM -1.3743331004231 0.115041848040997 no 2974 0.0846691473703668 4400 717353 SGTC_1348 1493-0373 93.8 µM -1.37765013856991 0.114490891837263 no 2975 0.0841556664117265 4445 3010129 SGTC_3185 9108267 49.47 µM -1.37885452494447 0.114291310192591 no 2976 0.0839698057505227 4424 4910486 SGTC_1320 1313-0481 95.3 µM -1.380854804658 0.11396038685867 no 2977 0.0836618043050525 4389 6813365 YLR208W SEC13 SGTC_1682 st012968 530 nM -1.38181720696174 0.113801411916986 no 2978 0.0835139171555182 4408 24207270 SGTC_3141 9094609 49.47 µM -1.3822651225884 0.113727476656696 no 2979 0.083445155416923 4385 25236309 YDL196W YDL196W SGTC_811 0416-0114 265 µM -1.3859342413026 0.11312312177729 no 2980 0.0828834919846593 4452 6612453 SGTC_1488 4013-0813 75.9 µM -1.38706592833837 0.112937180434139 no 2981 0.0827108301404714 4401 2910057 SGTC_1555 citronellol 128 µM -1.38804381080169 0.112776685668502 no 2982 0.0825618524259501 4391 8842 A terpine precursor. SGTC_1515 3460-0031 42.1 µM -1.38923282670332 0.11258175813571 no 2983 0.0823809813297473 4403 2876596 SGTC_1212 0520-0165 585 µM -1.39480867672722 0.111670862284453 no 2984 0.0815367708472963 4502 5403258 SGTC_3343 9148379 18.9835 µM -1.39719478613554 0.111282671980479 no 2985 0.0811775020918964 4439 1955036 SGTC_644 1498-1197 63.3 µM -1.40016343390548 0.110801059774567 no 2986 0.0807321914887212 4461 6741615 SGTC_1569 carminic acid 40.6 µM -1.40028950759896 0.110780639589044 no 2987 0.0807133207786637 4515 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1993 st073995 70.8 µM -1.40080431661977 0.110697283838837 no 2988 0.0806362987359873 4439 3098394 SGTC_1205 4161-2785 76 µM -1.40163596565387 0.110562721632993 no 2989 0.0805119906472877 4448 3498106 SGTC_1507 4075-3230 155 µM -1.40707184155186 0.109686075028205 no 2990 0.0797030434337965 4393 659771 SGTC_104 0074-0074 590.992 µM -1.40743532718569 0.109627634008448 no 2991 0.0796491709457769 4292 3943124 SGTC_2251 lansoprazole 556 µM -1.41038073687275 0.109154897098423 no 2992 0.079213645117958 4403 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2287 7945887 168.79 µM -1.41046672938501 0.109141117381748 no 2993 0.0792009568962405 4455 1245853 SGTC_110 0850-0284 111.64 µM -1.41209599512191 0.108880274775016 no 2994 0.0789608489114173 4353 3906265 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.41331322016839 0.108685691875584 no 2995 0.0787818242859223 4464 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1938 st074717 56.4 µM -1.41993645437039 0.107631298318167 no 2996 0.0778130909081785 4315 17250979 SGTC_1633 st005664 67.9 µM -1.42037589305823 0.10756160298989 no 2997 0.0777491385822024 4424 2063822 SGTC_85 0868-0259 160.055 µM -1.4235086792869 0.107065682785404 no 2998 0.0772943739430359 4385 83173 SGTC_1292 0kpi-0043 232 µM -1.42396211828087 0.106994040212136 no 2999 0.0772287191261312 4472 3333905 SGTC_1117 retinoic acid 1.10837 µM -1.42620190430748 0.106640665159931 no 3000 0.07690503506203 4487 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_608 k048-0125 159 µM -1.43269567310922 0.105620895129988 no 3001 0.0759724132892847 4502 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1177 0983-0204 23.6 µM -1.44023694180494 0.104445498976996 no 3002 0.0749001874725723 4480 766818 SGTC_896 0964-0007 44.5 µM -1.44075491646547 0.104365115719832 no 3003 0.0748269671113512 4409 6756758 SGTC_878 0828-0289 13.7 µM -1.44274873921933 0.104056117524785 no 3004 0.0745456319972225 4417 745350 YLR208W SEC13 SGTC_35 0133-0054 64.071 µM -1.44355722418191 0.103931009540284 no 3005 0.0744317823935153 4431 99677 SGTC_1583 clindamycin 39.6 µM -1.44536006064327 0.103652424808461 no 3006 0.0741783878474638 4426 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_3105 9121040 49.47 µM -1.44826588859369 0.1032045405723 no 3007 0.0737713518623276 4424 41448907 SGTC_2793 7325131 81.82 µM -1.45314656878642 0.102455431669805 no 3008 0.0730915317958624 4419 4176441 SGTC_1649 st011737 51.3 µM -1.45365680477435 0.102377347189797 no 3009 0.0730207397542761 4489 1761035 SGTC_79 0052-0007 94.094 µM -1.45717239706005 0.101840511068246 no 3010 0.0725343990067812 4452 2801472 SGTC_1447 4239-0816 81.9 µM -1.45859119733178 0.10162443950059 no 3011 0.0723388289213742 4479 1341554 SGTC_1605 st000082 49.1 µM -1.45985564127957 0.10143215660859 no 3012 0.0721648763322379 4424 1114022 SGTC_1973 st070275 50.2 µM -1.46278940225599 0.100987043158633 no 3013 0.0717625069185097 4431 17118334 SGTC_1108 betulinic acid 729.144 nM -1.46335670223156 0.100901136321645 no 3014 0.0716848998644991 4469 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_3110 9122132 49.47 µM -1.46449039533383 0.100729619625458 no 3015 0.0715300027274917 4499 918317 SGTC_664 1222-0054 14.9 µM -1.46647387885901 0.10043004955011 no 3016 0.0712596161666686 4446 6813991 SGTC_340 k038-0059 454 µM -1.47292050481185 0.0994608916557337 no 3017 0.0703862361835195 4456 23733424 SGTC_2959 9079155 11 µM -1.47521225886655 0.0991180115686508 no 3018 0.0700777433415055 4488 16189457 SGTC_2135 5326629 150.42 µM -1.47689272656893 0.098867138828786 no 3019 0.0698521974715284 4433 5020077 SGTC_2415 st077333 57.7 µM -1.49082109052872 0.0968056724529751 no 3020 0.0680042365021481 4496 2766255 SGTC_99 0109-0120 622.8 µM -1.49140434889547 0.0967200411367374 no 3021 0.0679276835130848 4493 759414 SGTC_686 1319-0111 510 µM -1.4926476436111 0.0965376920201984 no 3022 0.067764722510751 4502 4562600 SGTC_335 4077-0256 27.6 µM -1.49842568475671 0.0956935633253337 no 3023 0.0670113436531957 4429 3121989 SGTC_2810 7959871 45.46 µM -1.50067749265186 0.0953660658122309 no 3024 0.0667194986271881 4448 2974535 SGTC_2188 6126565 140.678 µM -1.500968929774 0.0953237402769586 no 3025 0.0666817989853686 4404 874518 SGTC_2857 9024691 58.44 µM -1.50173013065838 0.095213255991183 no 3026 0.0665834095348261 4513 16478292 SGTC_998 3996-0085 177 µM -1.50209996426419 0.0951596106466838 no 3027 0.0665356470612506 4522 715391 SGTC_2354 9060492 162 µM -1.50265504945852 0.0950791358486485 no 3028 0.0664640098963884 4510 6471895 SGTC_1648 st011736 69.8 µM -1.50485412695336 0.0947608119872728 no 3029 0.0661807921507399 4479 2855514 SGTC_1362 1611-0397 101 µM -1.50515235298116 0.0947177033157528 no 3030 0.0661424559063701 4476 27816 SGTC_353 1988-1175 58.3 µM -1.5068878747209 0.0944671198362851 no 3031 0.0659196999745365 4312 2788357 SGTC_898 1000-0849 28.3 µM -1.50873591339077 0.0942008283127192 no 3032 0.0656831419626289 4497 6751807 SGTC_2077 5212015 200 µM -1.51025977913978 0.0939816650780172 no 3033 0.0654885751998092 4417 780900 SGTC_805 3852-0218 479 µM -1.52288542270029 0.09218029451449 no 3034 0.0638936867072121 4478 6615355 SGTC_2333 9017922 200 µM -1.52413153687044 0.0920038998425775 no 3035 0.0637379280355746 4509 3163164 SGTC_2229 7354935 190 µM -1.53166949530904 0.0909421844243532 no 3036 0.0628020068280856 4490 318112 SGTC_2318 6029776 164 µM -1.53193780480155 0.0909045614743858 no 3037 0.0627688916610279 4531 818325 SGTC_3269 9137823 49.47 µM -1.53279433552389 0.090784534115949 no 3038 0.0626632683803161 4452 17682936 SGTC_509 pifithrin 175 µM -1.53355181246393 0.0906784853845399 no 3039 0.0625699754103407 4596 4817 A p53 inhibitor. SGTC_1269 0831-0796 3.05 µM -1.53519335239035 0.0904489811208412 no 3040 0.0623681703733796 4543 927758 SGTC_3019 9081971 49.47 µM -1.5354105115599 0.0904186523528033 no 3041 0.0623415116602677 4506 16451803 SGTC_3064 1327-0027 10 µM -1.5383080445723 0.0900147009454656 no 3042 0.0619866568603476 4482 16000455 YPR107C YTH1 SGTC_1454 4239-0054 42.6 µM -1.53980907372052 0.08980596719441 no 3043 0.0618034497576463 4568 1340767 SGTC_2395 5646831 180.19 µM -1.54007540050114 0.0897689692914601 no 3044 0.0617709876179643 4494 6808628 SGTC_1268 0828-0275 2.46 µM -1.54678859333374 0.0888401165836365 no 3045 0.0609571158287786 4560 745337 SGTC_734 2023-0417 80 µM -1.5504302173058 0.0883392565083289 no 3046 0.0605191452652492 4523 3935732 SGTC_95 0471-0001 561.058 µM -1.55150773133089 0.0881914620549455 no 3047 0.0603900280040052 4509 4015405 SGTC_1444 4112-3581 28 µM -1.55690444846118 0.0874540075664361 no 3048 0.0597465865717587 4603 2877249 SGTC_1332 1480-0653 17.5 µM -1.55799329159693 0.0873057781402611 no 3049 0.0596174191877029 4525 5749438 SGTC_218 alverine citrate 93.75 µM -1.55912397147453 0.0871520518764355 no 3050 0.0594835205027771 4577 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3165 9101544 49.47 µM -1.56026326573042 0.0869973589470423 no 3051 0.0593488402153796 4514 5002184 SGTC_2386 9075165 157.42 µM -1.56080238338942 0.0869242292906934 no 3052 0.0592851924654133 4506 16452277 SGTC_244 nsc-207895 1.295 µM -1.56094774421712 0.0869045194029989 no 3053 0.0592680404599417 4310 42640 SGTC_1392 3455-1037 33.9 µM -1.56764818577287 0.0859996075242563 no 3054 0.0584816300398668 4535 981132 SGTC_3082 9117008 49.47 µM -1.57429009566228 0.0851095772591634 no 3055 0.0577101992343259 4563 41448529 SGTC_311 1315-0136 58 µM -1.57827522655736 0.0845788847534864 no 3056 0.0572511973235323 4566 6759207 SGTC_1208 2323-2347 50.3 µM -1.58280509857848 0.0839786687661851 no 3057 0.0567329471368244 4554 5412760 SGTC_2846 9008642 19.48 µM -1.58737180635207 0.0833768151677144 no 3058 0.0562142304223381 4537 2992898 SGTC_1477 0139-0234 16 µM -1.58835863863832 0.0832471860445703 no 3059 0.0561026323643369 4556 620880 SGTC_1853 st056710 91.2 µM -1.59070795301418 0.082939192716908 no 3060 0.0558376581337428 4572 269167 SGTC_3282 9108498 15.4605 µM -1.59139564869984 0.0828491987171233 no 3061 0.0557602814877899 4527 16459645 SGTC_2836 9010338 19.48 µM -1.59235109865059 0.0827242875290112 no 3062 0.0556529187162385 4496 2994051 SGTC_1124 fisetin 1.16336 µM -1.59654571648874 0.0821775786792436 no 3063 0.0551835037105855 4549 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2896 9052656 71.43 µM -1.59784814615536 0.0820083803942679 no 3064 0.0550383883043211 4233 6469436 SGTC_263 alizarin 107.927 µM -1.59992186308679 0.0817395262498371 no 3065 0.0548079592529749 4577 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2254 7938975 95.19 µM -1.60271280798307 0.0813787341777197 no 3066 0.0544990372399814 4574 2969277 SGTC_2165 5727197 32.143 µM -1.6029381165647 0.0813496604854385 no 3067 0.0544741586479624 4576 1361712 SGTC_2368 9071271 200 µM -1.60699893531424 0.0808269970386726 no 3068 0.0540273008316575 4533 27209959 SGTC_1315 1237-0019 3.69 µM -1.60852194460464 0.0806316273292525 no 3069 0.0538604569963891 4561 825140 SGTC_1266 0828-0227 32.9 µM -1.60966370918799 0.0804853972812195 no 3070 0.0537356458313831 4523 3913820 SGTC_2539 epi(13)torulosol 80 µM -1.61011588757482 0.080427540524116 no 3071 0.053686279647057 4516 6708597 SGTC_759 3486-0358 89.3 µM -1.61293256861503 0.080067850166434 no 3072 0.0533795792515878 4522 875103 SGTC_1928 4'-methoxychalcone 40.3 µM -1.61396625694348 0.0799361535840494 no 3073 0.0532673727855675 4542 641818 SGTC_215 1287-0124 461.5 µM -1.61399976439864 0.0799318873247871 no 3074 0.0532637386951748 4587 5560863 SGTC_986 1493-0483 84 µM -1.61616175962529 0.0796569800927475 no 3075 0.0530296721077536 4522 40079 SGTC_2403 6032726 181.2 µM -1.61889622981713 0.0793103053656796 no 3076 0.0527347961080546 4543 2881040 SGTC_2575 plumbagin 510 nM -1.62060156599886 0.0790946827010146 no 3077 0.0525515580883753 4485 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1112 tnp00069 1.16933 µM -1.62186225204653 0.0789355671998874 no 3078 0.0524164227939844 4520 145826 SGTC_2537 larixol 68.93 µM -1.62305992017968 0.0787846301101512 no 3079 0.0522882981848439 4521 6708759 SGTC_656 4090-1979 187 µM -1.62696423269729 0.0782941042848078 no 3080 0.0518723472203397 4581 22330961 SGTC_9 0092-0002 10.449 µM -1.62809737794335 0.0781521739322367 no 3081 0.0517521197249816 4557 759368 SGTC_2512 diallyl trisulfide 49.23 µM -1.63449727561799 0.0773542261645449 no 3082 0.0510772389143803 4609 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_211 3455-0679 143.504 µM -1.64183370869131 0.0764471403092684 no 3083 0.0503122355751792 4543 748649 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.64394653991881 0.0761874139002722 no 3084 0.050093622815597 4494 17037758 SGTC_2848 9016370 25.97 µM -1.64605467354456 0.0759289348920985 no 3085 0.049876251595837 4534 7894410 SGTC_2458 5808907 16.39 µM -1.64786537397763 0.0757074578240041 no 3086 0.0496901501244963 4665 2731747 SGTC_3006 9075424 71.4286 µM -1.65045852797469 0.0753911319200465 no 3087 0.0494245944403892 4536 7465181 SGTC_2760 etidronate 98.04 µM -1.65497028863434 0.0748431672774327 no 3088 0.0489652624569287 4530 3305 A chelator and antioxidant. SGTC_1830 st055982 50.3 µM -1.6581663757265 0.0744568367889583 no 3089 0.0486419447519765 4564 455313 An antimicrobial agent. SGTC_31 0508-1974 57.237 µM -1.65829223740429 0.0744416543377652 no 3090 0.0486292475359372 4530 6810525 SGTC_1908 st060353 56.5 µM -1.6583011314349 0.0744405815574405 no 3091 0.0486283503858825 4564 4227716 SGTC_1029 k015-0030 64.7 µM -1.65962080478548 0.0742815359401701 no 3092 0.048495380142349 4590 2208316 SGTC_132 0417-1715 25.805 µM -1.66612393453195 0.0735015735427545 no 3093 0.0478443661355886 4543 6769098 SGTC_2141 5621638 7.665 µM -1.6689462693387 0.0731650278519731 no 3094 0.0475640143569963 4585 2856238 SGTC_1318 1280-3875 124 µM -1.67222408512872 0.0727756502061191 no 3095 0.0472400714092162 4601 373245 SGTC_1475 4092-1048 11.7 µM -1.67437993318446 0.0725204193757809 no 3096 0.0470279770082988 4586 2881759 SGTC_1420 4'-methoxyflavone 42 µM -1.67826379504709 0.0720623401002763 no 3097 0.0466478063048648 4591 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_798 1287-0182 476 µM -1.68144525380182 0.0716887606907633 no 3098 0.0463382308922193 4619 1649755 SGTC_2929 9013348 24.6 µM -1.68414061588053 0.0713734247204612 no 3099 0.0460772482717512 4551 2995952 SGTC_634 1611-4317 11.2 µM -1.68919939514853 0.0707844633203833 no 3100 0.0455906124412686 4598 2843522 SGTC_1235 benzylparaben 21.5 µM -1.69142705758158 0.070526298047471 no 3101 0.0453776340890947 4628 7180 SGTC_567 1080-0542 68.4 µM -1.6923141301849 0.0704236963408777 no 3102 0.0452930475360706 4491 5950415 SGTC_961 1252-1571 372 µM -1.69643115319294 0.0699490097206686 no 3103 0.0449021290456123 4596 6813498 SGTC_752 1896-0090 130 µM -1.69893591756785 0.069661421004031 no 3104 0.0446656292809523 4601 772567 SGTC_2558 carylophyllene oxide 100 µM -1.7005257290546 0.0694793569205425 no 3105 0.0445160405168769 4665 6708694 An oxygenated terpenoid and antifungal agent. SGTC_1779 st039427 55 µM -1.70177380323807 0.0693366852791707 no 3106 0.0443988895620562 4582 1124498 SGTC_1045 1348-1485 165 µM -1.70984300028619 0.0684197077617172 no 3107 0.0436474545301886 4567 6810614 SGTC_513 4245-1575 41.7 µM -1.71209922041171 0.0681649937622273 no 3108 0.0434391925126577 4416 719745 SGTC_2227 7312221 64.1025 µM -1.71808632711869 0.0674926326311675 no 3109 0.0428904351896616 4691 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1114 scopoletin 1.73284 µM -1.72566071253284 0.0666493748456445 no 3110 0.0422042349716103 4627 5280460 A coumarin with genotoxic properties. SGTC_909 3448-9333 149 µM -1.72598762934206 0.0666131635348462 no 3111 0.0421748191501767 4526 3344074 SGTC_1786 berberine 21.6 µM -1.7264152782765 0.0665658175066138 no 3112 0.0421363645486396 4507 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2582 agaric acid 100 µM -1.72909913641755 0.066269275685441 no 3113 0.0418956768535893 4227 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1929 genistein trimethyl ether 50.5 µM -1.73237107904945 0.0659091410256118 no 3114 0.0416037569345303 4553 136420 SGTC_3021 9087658 49.47 µM -1.7347928060317 0.0656435656155177 no 3115 0.0413887554410039 4622 25237042 SGTC_1690 st023502 41.2 µM -1.73529781161531 0.0655882895507703 no 3116 0.0413440345898246 4608 24207482 SGTC_2926 9010726 65.15 µM -1.73538686557137 0.0655785457747885 no 3117 0.0413361524660246 4583 2994293 SGTC_1184 1269-1718 139 µM -1.73967774911261 0.0651103904017643 no 3118 0.0409578092734613 4633 5403821 SGTC_150 3970-0969 77.2 µM -1.74590301610305 0.0644358009909829 no 3119 0.0404139028544787 4606 6615640 SGTC_2424 5537928 59.2 µM -1.75028996280051 0.0639636885301923 no 3120 0.0400341459974102 4610 5382802 SGTC_843 0310-0051 143 µM -1.75048677856536 0.0639425709136787 no 3121 0.0400171767991534 4622 2065037 SGTC_1897 st060201 15 µM -1.75302219708943 0.0636710142643763 no 3122 0.0397990985087271 4600 611878 SGTC_1924 st058459 75.1 µM -1.75450286187053 0.0635128427874494 no 3123 0.0396721899783348 4583 688683 SGTC_1630 st005209 31.3 µM -1.76377647905701 0.0625291375855556 no 3124 0.0388848095137723 4610 3367314 SGTC_2602 kawain 100 µM -1.7683636711095 0.0620469591668457 no 3125 0.03850006291515 4577 5369129 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.76878624236603 0.0620026873226347 no 3126 0.0384647767529672 4635 94937 An inhibitor of serotonin biosynthesis. SGTC_1704 st028805 70.8 µM -1.77306804490447 0.0615554816130745 no 3127 0.0381087161396926 4651 2876101 SGTC_181 1447-1644 8.07 µM -1.77925361057906 0.0609138933475818 no 3128 0.0375990963187129 4585 534600 SGTC_568 1193-0097 7.48 µM -1.77971905557637 0.0608658280861616 no 3129 0.0375609751547322 4425 3646150 SGTC_3324 9138759 60.749 µM -1.7830520499624 0.0605225046757713 no 3130 0.0372889154287785 4622 45595710 SGTC_2090 5301565 104.445 µM -1.78331521531393 0.0604954613408673 no 3131 0.0372675029882356 4630 2056344 SGTC_2649 anisomycin 9.56 µM -1.78970924836328 0.0598413004209905 no 3132 0.0367503324292938 4664 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_591 4299-0174 154 µM -1.79069077095308 0.0597413752045899 no 3133 0.0366714657717616 4655 5509088 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -1.79588434517967 0.0592148108092055 no 3134 0.0362564563433657 4635 7104 SGTC_257 daunorubicin 18.5 µM -1.79660520070728 0.0591420134797466 no 3135 0.0361991590943571 4650 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2592 piperlongumine 83.33 µM -1.79902113161373 0.0588985466303585 no 3136 0.0360076690384764 4612 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1317 1273-0028 910 nM -1.80169698029149 0.0586298050631163 no 3137 0.0357965467267375 4636 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.80302862177274 0.058496424483834 no 3138 0.0356918598826779 4621 803109 SGTC_1512 0259-0544 12.2 µM -1.81356061170257 0.0574498915153781 no 3139 0.0348726995657756 4604 18476 SGTC_1422 4031-0024 15.5 µM -1.8144833523742 0.0573589077665312 no 3140 0.0348016717263376 4587 782427 SGTC_3249 9135183 49.47 µM -1.81499964590674 0.0573080498611456 no 3141 0.0347619819511268 4582 4902779 SGTC_431 k089-0097 107 µM -1.81768434545759 0.0570441631597915 no 3142 0.0345561958806865 4334 5499420 SGTC_2545 solidagenone 89.61 µM -1.81804366016535 0.0570089178034588 no 3143 0.0345287299777928 4597 6708572 An anti ulcer agent SGTC_255 tunicamycin 200.472 nM -1.81862875061333 0.0569515626860291 no 3144 0.0344840442273394 4556 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1365 1672-3266 55.4 µM -1.82305639671435 0.0565190020335565 no 3145 0.0341474248369357 4652 6415873 SGTC_1685 st024049 53.0905 µM -1.83372031729147 0.0554878117640093 no 3146 0.0333477605561188 4660 1941139 SGTC_2046 4110841 106 µM -1.84256082049435 0.0546442541191241 no 3147 0.0326965793753615 4649 44119630 YMR134W ERG29 SGTC_1756 st041558 35.5 µM -1.84557206859843 0.0543592482448504 no 3148 0.0324771826171267 4699 3955792 SGTC_2849 9019321 12.99 µM -1.84611167733688 0.0543083003144123 no 3149 0.0324379958269579 4635 16489627 SGTC_1119 parthenolide 318.541 nM -1.84786037482665 0.054143454094393 no 3150 0.0323112720691552 4654 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_433 pimozide 108 µM -1.85302029434219 0.0536593461885625 no 3151 0.031939724946393 4570 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1142 3253-1408 9.78 µM -1.85624784213645 0.0533582822297024 no 3152 0.0317091198534426 4635 256655 SGTC_236 1509-0011 5.31 µM -1.86583047202012 0.0524723022817536 no 3153 0.0310325437943608 4646 3107280 SGTC_1796 st049173 110.4 µM -1.87433489557138 0.0516958274981214 no 3154 0.0304421403572079 4639 94134 SGTC_685 1278-0033 54.9 µM -1.8780436687807 0.0513600803148306 no 3155 0.0301875957156656 4679 3590572 SGTC_2607 solasodine 47.35 µM -1.87884024171386 0.0512881950648955 no 3156 0.0301331552279653 4582 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_1677 st019204 53.9 µM -1.88586050920037 0.0506581198581559 no 3157 0.0296568771785419 4646 3945625 SGTC_2160 5660466 132.927 µM -1.88836888186871 0.0504344918454715 no 3158 0.0294882229416214 4614 2859134 SGTC_2597 laccaic acid a 100 µM -1.89508438466149 0.0498396576866222 no 3159 0.0290406115319213 4606 5491415 A textile dye. SGTC_929 2805-0021 398 µM -1.89614933145778 0.0497458448469185 no 3160 0.0289701504820234 4672 3098024 SGTC_859 0439-0102 54.6 µM -1.89875175238997 0.0495171862171781 no 3161 0.0287985617810743 4680 610143 SGTC_1134 3477-0009 42.5 µM -1.90356093504322 0.0490968411390361 no 3162 0.0284836952976904 4652 3973534 SGTC_1014 4130-3005 69.3 µM -1.90541606495178 0.0489354578540595 no 3163 0.0283630042899581 4659 743608 SGTC_626 0214-0009 33 µM -1.91537686741946 0.0480761725915715 no 3164 0.0277222295292882 4690 3437874 SGTC_2704 st078022 71.1 µM -1.91550936779046 0.0480648241363261 no 3165 0.0277137878121036 4682 54697681 SGTC_1162 k048-0130 20.1 µM -1.9163225938813 0.0479952195080492 no 3166 0.0276620233588553 4665 6797406 SGTC_1174 0739-0097 51.1 µM -1.91870200069703 0.0477920275708917 no 3167 0.027511029088467 4671 728447 SGTC_1425 4048-4433 7.33 µM -1.92271188317794 0.0474511584598163 no 3168 0.0272581218175652 4720 23734946 SGTC_1642 st009582 77.7 µM -1.92298571010458 0.0474279524159491 no 3169 0.0272409222545042 4658 6739311 SGTC_3104 9120930 49.47 µM -1.92631566018746 0.0471464757794356 no 3170 0.0270324856001451 4670 17014836 SGTC_3148 9097893 49.47 µM -1.93013403051451 0.0468253634836979 no 3171 0.0267951164356114 4630 17174100 SGTC_1089 terbinafine 2.25 µM -1.9302959583272 0.0468117847632151 no 3172 0.0267850887769349 4682 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_510 ag-490 170 µM -1.93096519423131 0.0467556983964196 no 3173 0.0267436784237447 4750 5328779 SGTC_219 mitoxanthrone 164.414 µM -1.9420487441986 0.0458346403178131 no 3174 0.0260655998137315 4648 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2136 5328288 199.296 µM -1.94548138494028 0.0455523590463884 no 3175 0.0258585340054497 4636 262395 SGTC_2048 5246248 200 µM -1.9486074478125 0.0452965067602315 no 3176 0.0256711610121167 4685 677046 SGTC_526 4469-0568 170 µM -1.95691126094776 0.0446224928431006 no 3177 0.0251789511849592 4648 2901964 SGTC_216 k038-0035 28.382 µM -1.96241367856513 0.0441803329066542 no 3178 0.024857170762979 4646 4444231 YPR107C YTH1 SGTC_486 niguldipine 82 µM -1.96464741456123 0.0440018466391408 no 3179 0.0247275300660656 4731 1236 A calcium channel blocker. SGTC_2035 5154463 94.595 µM -1.96482358291467 0.0439877947130166 no 3180 0.0247173298513366 4686 2769623 SGTC_1355 1499-0035 1.68 µM -1.96753536550541 0.0437719478187226 no 3181 0.0245607614532932 4688 1548538 SGTC_2194 5927483 104.545 µM -1.96908371882176 0.0436490889122379 no 3182 0.0244717390735717 4700 760979 SGTC_847 0342-0274 5.54 µM -1.97250789748886 0.04337837491592 no 3183 0.0242758278268636 4670 18097 SGTC_149 3970-0822 46.1 µM -1.98054532741668 0.0427482630462185 no 3184 0.0238211426702146 4654 3114250 YBL034C STU1 SGTC_2470 5664817 21.68 µM -1.98963830544449 0.0420443410394597 no 3185 0.023315396660166 4724 2859561 SGTC_306 1672-3436 11.6 µM -1.99130039199123 0.0419166925006191 no 3186 0.0232239362007317 4688 6797378 SGTC_484 loperamide 105 µM -1.99186232693163 0.04187360683877 no 3187 0.023193082724402 4760 3955 An opioid-receptor agonist. SGTC_1489 4065-0444 182 µM -1.99631496018467 0.0415334731452803 no 3188 0.0229498253324849 4688 2877968 SGTC_1426 4048-4480 71.7 µM -2.00590068078997 0.0408088221393198 no 3189 0.0224334228077847 4700 14224343 SGTC_1834 st055981 52.8 µM -2.0060274852708 0.0407993053031511 no 3190 0.0224266578102531 4653 471719 YDL150W RPC53 SGTC_849 0386-0493 241 µM -2.01363275938416 0.0402318046086247 no 3191 0.0220240521874436 4699 726119 SGTC_2272 7805186 180 µM -2.01682943947306 0.0399951921428254 no 3192 0.0218566577955692 4691 2956062 YPR165W RHO1 SGTC_1172 0370-0043 85 µM -2.02103270782924 0.0396857961911186 no 3193 0.0216381896815015 4700 376585 SGTC_2591 skatole 100 µM -2.02528125072792 0.039375048211167 no 3194 0.0214192463212263 4658 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2171 5739187 198.077 µM -2.02637273070692 0.0392955353557956 no 3195 0.0213633016070697 4657 2262761 SGTC_980 1473-0395 201 µM -2.03149455910916 0.0389241604139252 no 3196 0.021102425458088 4656 768876 SGTC_1711 st032263 62.8 µM -2.03265218095217 0.0388406204851536 no 3197 0.0210438378273181 4691 3958979 SGTC_3205 9113483 49.47 µM -2.03464372260696 0.0386972423815174 no 3198 0.0209433673116713 4646 17018033 SGTC_3097 9117246 49.47 µM -2.03863584683854 0.038411133779603 no 3199 0.0207431924069735 4700 16423892 SGTC_393 acivicin 6.25 µM -2.0389401861682 0.0383893932341707 no 3200 0.02072799877356 4580 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_699 0375-0592 111 µM -2.04036844193049 0.0382874994379305 no 3201 0.0206568213198355 4740 762578 SGTC_2223 6903751 107.57 µM -2.04496120856096 0.0379613386743869 no 3202 0.0204293413171757 4682 5598863 SGTC_2516 gossypol 71.55 µM -2.04838931537802 0.0377193680371265 no 3203 0.0202609338144711 4702 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_716 1683-5115 658 µM -2.04962538285741 0.0376324304482576 no 3204 0.0202005007522138 4680 723597 SGTC_1143 3454-2408 5.08 µM -2.05489703923894 0.037263488519063 no 3205 0.0199444752538086 4717 X1143 SGTC_202 3594-0513 34.79 µM -2.05636446704005 0.0371613166137475 no 3206 0.0198736993067963 4753 708429 SGTC_3306 9127676 59.7925 µM -2.05949990672643 0.0369437739112513 no 3207 0.0197231869714703 4647 41905287 SGTC_2690 usnic acid 100 µM -2.07036550616541 0.0361979403486771 no 3208 0.0192090647385837 4681 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3288 9119690 36.221 µM -2.0823482575684 0.035389764819693 no 3209 0.018655335494467 4692 17595618 YKL019W RAM2 SGTC_111 0083-0039 52.457 µM -2.08442610003493 0.0352511417803137 no 3210 0.018560712893538 4693 759313 SGTC_2120 5538279 151.968 µM -2.08745024851577 0.0350501822183059 no 3211 0.0184237269186876 4714 2058197 SGTC_595 3909-8003 73.7 µM -2.08880744378643 0.0349603005298645 no 3212 0.0183625300370916 4738 699517 SGTC_403 arphamenine a 50 µM -2.09624490902544 0.0344710997374696 no 3213 0.018030235501631 4706 5487158 An arginine aminopeptidase inhibitor. SGTC_3108 9121785 49.47 µM -2.09960147582478 0.0342521700798877 no 3214 0.017881956425529 4599 17140271 SGTC_753 1322-0200 289 µM -2.10223642926021 0.0340811089996384 no 3215 0.017766285070821 4734 5403907 SGTC_2317 5986382 200 µM -2.10348398715995 0.0340003629559398 no 3216 0.0177117417970778 4702 877883 SGTC_876 0720-0963 56.8 µM -2.10614872774796 0.033828419057448 no 3217 0.0175957176279533 4708 765861 SGTC_2876 9059903 25.97 µM -2.11243849713926 0.0334254038652219 no 3218 0.0173244279786359 4703 6916095 SGTC_1726 st035556 14.5795 µM -2.11646123461147 0.0331697268885655 no 3219 0.0171527994193598 4701 5919439 SGTC_1984 st072354 53.1 µM -2.12017903228341 0.032934865884911 no 3220 0.0169954749857035 4639 5762938 SGTC_698 k064-0052 127 µM -2.12025163235359 0.0329302932664757 no 3221 0.0169924151206085 4754 5088751 SGTC_2085 5307070 144.047 µM -2.12163644208507 0.0328431730062974 no 3222 0.016934139841582 4665 2840351 SGTC_894 0960-0238 55.9 µM -2.12745958424105 0.0324789080219427 no 3223 0.0166909579750226 4711 6741907 YDL195W SEC31 SGTC_966 1300-0360 30.2 µM -2.13248874790771 0.0321669983661833 no 3224 0.0164833442628185 4706 70588 SGTC_983 1491-0821 12.2 µM -2.13291635203925 0.0321405927249334 no 3225 0.0164657943452709 4719 46495113 SGTC_3073 9114972 49.47 µM -2.14189312157039 0.0315903727808688 no 3226 0.0161010417509375 4711 41905075 SGTC_408 cantharidin 100 µM -2.1423525692844 0.0315624222214308 no 3227 0.0160825607818923 4717 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1190 1486-1332 13 µM -2.14465350380571 0.0314227519213851 no 3228 0.0159902805211446 4735 4150046 SGTC_418 lividomycin a 100 µM -2.14915430816391 0.0311510233950977 no 3229 0.0158110849602529 4726 72394 An antibiotic. SGTC_1407 3909-7909 12.3 µM -2.14983917123893 0.0311098468304569 no 3230 0.0157839692751007 4725 4411780 SGTC_2664 lyso-paf C-16 73.48 µM -2.15093576417617 0.0310440092856624 no 3231 0.0157406350890322 4708 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_621 3584-0052 32.1 µM -2.15356187932407 0.0308868103996062 no 3232 0.0156372732411273 4735 2273927 SGTC_1211 1056-0033 32.3 µM -2.15558122258411 0.0307663813886426 no 3233 0.0155581900444929 4722 6741922 SGTC_597 k018-0003 82.8 µM -2.15858898633136 0.0305877262012252 no 3234 0.0154410339823631 4749 6786234 SGTC_2305 7443522 69.23 µM -2.16072336390772 0.0304614703036564 no 3235 0.0153583575061129 4650 5415886 SGTC_476 mead acid 10 µM -2.16608965207264 0.0301459418830608 no 3236 0.0151521683966337 4767 5312531 An omega 9 fatty acid. SGTC_987 1497-1013 404 µM -2.16798310369202 0.0300352588892033 no 3237 0.0150799860590979 4716 1676435 SGTC_3078 9116413 49.47 µM -2.19057918974878 0.0287402039109542 no 3238 0.0142411292235261 4697 17177322 SGTC_2586 curcumin 80 µM -2.20690687004007 0.0278335917997068 no 3239 0.0136602831852211 4643 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_659 k018-0002 107 µM -2.20736211912996 0.0278086590066 no 3240 0.013644385319305 4710 6797879 YHR007C ERG11 SGTC_2338 7999974 200 µM -2.23467471957001 0.0263465096358046 no 3241 0.0127193557321068 4691 315925 SGTC_897 1000-0139 31.4 µM -2.23531498625728 0.0263130196802429 no 3242 0.012698338444316 4711 6151020 SGTC_50 0929-0078 56.389 µM -2.2488859861586 0.0256114999385761 no 3243 0.012259875409711 4637 1377751 SGTC_1660 st012960 28.1 µM -2.25184777480451 0.0254604972921294 no 3244 0.0121659467043422 4752 24207266 SGTC_3242 9133940 49.47 µM -2.27496716957108 0.0243072262957512 no 3245 0.0114539496755541 4746 17248444 SGTC_177 1327-0068 8.361 µM -2.28063011452514 0.0240315265495397 no 3246 0.0112851718712832 4735 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_3090 9117696 49.47 µM -2.28434327676111 0.023852181714366 no 3247 0.0111756821938732 4731 7923821 SGTC_3145 9085516 49.47 µM -2.28920812305478 0.023618914624511 no 3248 0.0110336314299173 4708 25236195 SGTC_2353 9059630 146.67 µM -2.29795949750008 0.0232041200333538 no 3249 0.010782047220652 4745 4779114 SGTC_713 1488-1073 324 µM -2.30129959965686 0.0230474322218485 no 3250 0.0106873511884031 4744 3312542 SGTC_2510 benzyl isothiocyanate 8.31 µM -2.30509731574476 0.0228703607050452 no 3251 0.0105805619004496 4752 2346 DNA damaging agent; causes G2/M arrest. SGTC_2103 5378138 10 µM -2.30547167106709 0.0228529683173835 no 3252 0.0105700857781555 4769 244142 SGTC_499 genistein 192 µM -2.30723233499227 0.0227713180121991 no 3253 0.0105209356973395 4770 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1881 5652484 16 µM -2.31255517082701 0.0225259665629624 no 3254 0.0103735543389574 4725 2255129 SGTC_1547 harmine 94.2 µM -2.31519155144329 0.0224052726805805 no 3255 0.0103012257090195 4673 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3304 9125678 46.087 µM -2.31725257654462 0.0223112989331178 no 3256 0.0102449884969364 4727 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1008 4106-0037 6 µM -2.32230983560692 0.0220821180615505 no 3257 0.0101081291625501 4758 2905394 SGTC_1432 4049-0298 68.4 µM -2.3318011555679 0.0216573603332816 no 3258 0.00985557711128201 4762 741646 SGTC_156 3474-0145 5.642 µM -2.33750823546371 0.0214052946840812 no 3259 0.00970638661272045 4695 2265471 SGTC_2245 6637752 200 µM -2.34002998454239 0.0212947087608957 no 3260 0.00964109587431297 4742 681890 SGTC_444 curcumin 90.4 µM -2.35580813651173 0.020613705181306 no 3261 0.009241230552969 4670 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_284 0988-0104 32.6 µM -2.35882696344874 0.020485533816466 no 3262 0.00916640093379236 4730 4666532 SGTC_1229 0139-0193 12.2 µM -2.36256894560455 0.0203275970757884 no 3263 0.00907438263504286 4772 3090752 SGTC_1741 st038134 10.228 µM -2.36620176762567 0.0201752562477319 no 3264 0.00898582354837542 4741 1272587 SGTC_941 3237-0776 460 µM -2.36659749923081 0.0201587200380552 no 3265 0.00897622248269283 4733 760008 SGTC_1654 st012436 41.8 µM -2.37769939238973 0.0196994739234588 no 3266 0.00871051074399156 4771 4323132 SGTC_1602 st001878 87.6 µM -2.39273934270859 0.0190915152505778 no 3267 0.0083615584425339 4732 595405 YLR310C CDC25 SGTC_3217 9129673 49.47 µM -2.39627937464767 0.01895075920837 no 3268 0.00828123050840485 4724 17248312 SGTC_3194 9111903 49.47 µM -2.40436049406314 0.0186327480736294 no 3269 0.00810039420648507 4732 17087251 SGTC_2971 9092186 9.93 µM -2.41702697344285 0.018143436377351 no 3270 0.00782392875716903 4708 25236400 SGTC_1643 st009866 20.2 µM -2.41871208858749 0.0180791724972482 no 3271 0.00778778136954072 4754 3156273 YOR207C RET1 SGTC_73 0327-0325 16.231 µM -2.45256030790637 0.0168288378887583 no 3272 0.00709218001842375 4621 53298 SGTC_1262 0737-0114 49.6 µM -2.4553694237817 0.0167284772533039 no 3273 0.00703699362569803 4761 765919 SGTC_617 3770-0098 35 µM -2.45687880397981 0.0166747637581815 no 3274 0.00700749795508084 4721 5962639 SGTC_105 0111-0055 734.78 µM -2.45893530234507 0.0166018178098725 no 3275 0.00696748637929402 4759 5179370 SGTC_399 oxolinic acid 75 µM -2.4768367487105 0.0159782925243615 no 3276 0.006627625787618 4751 4628 A DNA gyrase inhibitor. SGTC_2768 sulfasalazine 50.2 µM -2.50157735805335 0.0151496664699934 no 3277 0.0061820713739706 4735 5384001 An antioxidant and salicylic acid derivative. SGTC_1000 4048-0884 8.67 µM -2.50557891789363 0.0150191736693523 no 3278 0.00611255566473797 4752 13040088 SGTC_2371 9071574 200 µM -2.50864721748057 0.0149197704166409 no 3279 0.00605972275010174 4770 45596039 SGTC_2871 9038510 12.99 µM -2.51945850334314 0.0145740135676759 no 3280 0.00587677468042632 4735 4945164 SGTC_2717 st081029 62.2815 µM -2.53095658109506 0.0142138809329249 no 3281 0.00568759643522171 4761 5292846 SGTC_1316 1272-0050 65.9 µM -2.54535828923225 0.0137736396995914 no 3282 0.00545828317569825 4776 7340392 SGTC_815 1582-0027 36.9 µM -2.58504939484659 0.0126207045999751 no 3283 0.00486825238150667 4769 3128206 SGTC_2089 5281248 129.67 µM -2.58863672317969 0.0125207409694725 no 3284 0.00481783434288106 4762 2737878 SGTC_2398 5228213 48.84 µM -2.58895370535161 0.0125119410734452 no 3285 0.00481340178555398 4735 80771 YMR134W ERG29 SGTC_1989 st071868 50.2 µM -2.60673537310146 0.0120267956319362 no 3286 0.00457049873843609 4772 16414057 SGTC_2636 apigenin dimethyl ether 100 µM -2.62052504737012 0.0116618769160135 no 3287 0.00438972402517354 4738 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3151 9099821 49.47 µM -2.62456240257355 0.0115568713408462 no 3288 0.00433801963118176 4743 17174189 SGTC_2645 abamectin 100 µM -2.62825484964511 0.0114615561358824 no 3289 0.00429120956065299 4764 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2275 7947463 200 µM -2.63699921365024 0.0112385521291985 no 3290 0.00418215127433704 4766 1225414 SGTC_1942 st076330 65.2 µM -2.64853953390049 0.0109500237547616 no 3291 0.00404201967405632 4760 24208414 SGTC_1196 1588-0294 184 µM -2.65338223466082 0.0108308807270309 no 3292 0.00398447863568126 4785 6144269 SGTC_2490 carminic acid 95.39 µM -2.65483114571914 0.0107954537631891 no 3293 0.00396740580428014 4755 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1824 st053723 68.6 µM -2.69819807868668 0.00978078427846885 no 3294 0.00348579725008422 4784 675225 SGTC_1733 st037357 54.9 µM -2.71195702855913 0.00947676410241065 no 3295 0.00334436316163743 4739 1272339 YGL099W LSG1 SGTC_29 0299-0004 12.984 µM -2.71967913623977 0.00930978164304728 no 3296 0.00326726449389121 4751 16871 A napthoquinone isolated from Swertia calycina. SGTC_2265 7929201 200 µM -2.72033629987368 0.00929569075914757 no 3297 0.00326077766602601 4753 1265108 SGTC_1646 st011709 75.6 µM -2.72936182187874 0.00910404558734006 no 3298 0.00317285182948139 4774 5757843 SGTC_855 0428-0020 25 µM -2.7320433146385 0.00904777825329607 no 3299 0.0031471432681687 4784 6812414 SGTC_949 1165-0505 146 µM -2.74379616879032 0.00880473871294086 no 3300 0.00303666177822915 4759 6244267 SGTC_3045 9092950 49.47 µM -2.74802156958948 0.00871876989174645 no 3301 0.00299780323435931 4766 44120432 SGTC_2489 cantharidin 73.42 µM -2.76148554257216 0.00844972532344807 no 3302 0.00287695320093989 4768 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_299 1273-0059 1.44 µM -2.77111579365359 0.00826178485885798 no 3303 0.00279322782932709 4613 2848077 SGTC_2900 5328528 85.29 µM -2.79418811757669 0.00782637662524423 no 3304 0.00260151009604291 4754 795359 SGTC_3207 9114163 49.47 µM -2.80156231298138 0.00769153778815576 no 3305 0.00254279093157301 4746 849233 SGTC_2969 9091408 28.7 µM -2.80777470945352 0.0075795340602556 no 3306 0.00249425561134642 4744 4286311 SGTC_2339 9000433 200 µM -2.82284960633384 0.00731369900482506 no 3307 0.00237994470850432 4764 2988954 SGTC_3077 9117319 49.47 µM -2.82604374248343 0.00725843967645024 no 3308 0.0023563414003272 4765 17154678 SGTC_3142 9086498 49.47 µM -2.85427951634935 0.00678574838649662 no 3309 0.00215672806369364 4720 25236367 SGTC_930 2810-3379 265 µM -2.86883960653142 0.00655279529246537 no 3310 0.00205990328725469 4777 1015764 SGTC_964 1287-0107 19.4 µM -2.87844041610261 0.00640308393628003 no 3311 0.00199823384233831 4769 51516812 YPR165W RHO1 SGTC_2007 4011539 71.82 µM -2.88901603827109 0.0062416823382162 no 3312 0.00193224681603786 4773 45595301 SGTC_195 4234-0266 16.654 µM -2.89695443219696 0.0061229069866638 no 3313 0.00188402240776459 4797 2303354 SGTC_2686 alizarin 95.37 µM -2.89902014186167 0.00609232977967092 no 3314 0.00187165423161674 4776 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_3259 9138485 49.47 µM -2.9729863220961 0.00508290954712247 no 3315 0.00147458796701607 4772 17646153 SGTC_2908 7930301 100 µM -2.98389753715848 0.00494734563758397 no 3316 0.00142301029882802 4771 2223178 SGTC_3345 9148410 3.559 µM -3.01287668859924 0.0046028093728817 no 3317 0.00129392023553558 4774 4903596 SGTC_214 4373-3496 70 µM -3.02082740363728 0.00451210462159171 no 3318 0.00126042504654143 4796 3779166 SGTC_3337 9144342 33.5465 µM -3.02495305440192 0.00446566949063676 no 3319 0.00124335861242449 4785 17682949 SGTC_2507 purpurin 79.67 µM -3.03286579725663 0.00437780252939657 no 3320 0.00121121652212839 4787 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1743 st037606 46.3785 µM -3.0496076403048 0.0041969672116032 no 3321 0.00114570252284651 4777 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -3.05865097146299 0.00410209185688703 no 3322 0.00111168009969354 4791 2374 Ca(2+)-ATPase inhibitor. SGTC_109 0132-0036 33.701 µM -3.06846510748354 0.00400130565841761 no 3323 0.00107580726681851 4789 67274 A color developer. SGTC_2271 7849410 118.62 µM -3.15046230533399 0.0032421639097419 no 3324 0.000815061452448283 4776 972430 SGTC_706 4262-0057 46.9 µM -3.15562099960374 0.00319904910242081 no 3325 0.000800784102976186 4790 883298 SGTC_2001 4023502 57.655 µM -3.17065484306668 0.00307632771460507 no 3326 0.000760478733949622 4791 108941 YCR052W RSC6 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -3.17329898158601 0.00305518736324387 no 3327 0.000753586150783703 4793 75037 A free radical scavenger. SGTC_1715 st032160 10.2275 µM -3.18551442098258 0.00295921146213223 no 3328 0.000722484510305594 4747 5289825 SGTC_2273 7815444 169.05 µM -3.19900903926134 0.00285635119887777 no 3329 0.000689504225187583 4780 2824616 SGTC_1450 4112-4260 37.6 µM -3.20539087048977 0.00280883925396563 no 3330 0.000674395910152194 4783 1633175 SGTC_1222 0366-0074 1.18 µM -3.22836021908753 0.00264367934363203 no 3331 0.000622510441850125 4797 286520 SGTC_1811 st050069 61.5 µM -3.30031903333865 0.00218149192138306 no 3332 0.000482874874661423 4804 3877702 SGTC_2405 ticlatone 3.52 µM -3.31804319377715 0.00207952221738958 no 3333 0.000453252325332733 4727 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_2976 9009005 19.48 µM -3.37579544998846 0.00177655299821084 no 3334 0.000368013092093862 4795 2993148 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -3.41987428000693 0.00157297005631065 no 3335 0.000313250411324029 4799 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2675 theaflavin digallate 100 µM -3.4446074744015 0.00146828212759471 no 3336 0.000285944614363321 4792 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_1742 st038235 28.8875 µM -3.44928523360426 0.00144921266980437 no 3337 0.000281036321108711 4794 564103 YBR002C RER2 SGTC_2621 lithochol-11-enic acid 100 µM -3.46386662640273 0.00139121133619531 no 3338 0.000266235222608935 4782 6708711 SGTC_187 1488-2104 32.728 µM -3.49376586255313 0.00127885721802283 no 3339 0.00023812925474879 4805 2852859 SGTC_2821 7996764 71.43 µM -3.55903490948685 0.00106185979189101 no 3340 0.000186110029562229 4787 2987135 SGTC_2763 lisinopril 49.32 µM -3.57903290600255 0.00100246954041894 no 3341 0.000172434023634107 4794 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_106 0092-0003 11.579 µM -3.63956491652479 0.000840786662455306 yes 3342 0.00013654954250984 4803 1072148 SGTC_2770 toltrazuril 17.5 µM -3.67065055461043 0.000767423120712701 yes 3343 0.000120966957389702 4804 68591 Kills coccidiodes. SGTC_2767 sibutramine 71.45 µM -3.69440079479319 0.000715395923086189 yes 3344 0.000110202960835589 4801 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2705 st078069 42.8 µM -3.69745825730381 0.00070893978018486 yes 3345 0.000108884507316742 4807 1530061 SGTC_1295 1013-0063 9.78 µM -3.71857860329367 0.000665788632970942 yes 3346 0.000100173475971662 4807 6826038 SGTC_3350 9150499 3.57 µM -3.76236633417882 0.000583940469324627 yes 3347 8.41566337336725e-05 4805 4910996 YPR165W RHO1 SGTC_2702 st077768 96.8 µM -3.91746893909183 0.000363051480981337 yes 3348 4.47417857288928e-05 4808 6484119 SGTC_3197 9113331 49.47 µM -3.93747126873112 0.000341056134849203 yes 3349 4.11723938385328e-05 4792 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_1927 st060202 13.8 µM -4.15369695670711 0.000170507653449961 yes 3350 1.63573185952224e-05 4808 688887 SGTC_2244 6635614 200 µM -4.44156261844994 6.44214904985657e-05 yes 3351 4.46539746397986e-06 4805 836499 SGTC_2343 7990716 14.84 µM -4.50358746671589 5.18402858893479e-05 yes 3352 3.34079247259518e-06 4809 6456862 SGTC_2110 5483698 200 µM -4.78301166237212 1.88394312394047e-05 yes 3353 8.63440510930037e-07 4808 2848765 YHR062C RPP1 SGTC_2266 7929956 200 µM -4.8939442616082 1.24151748770195e-05 yes 3354 4.9417420777312e-07 4804 2967153 SGTC_2907 7721985 69.9 µM -5.15214258117326 4.5482928364479e-06 yes 3355 1.28763557526197e-07 4809 3267881 SGTC_910 3454-3003 490 µM -6.23787728241001 3.97977188943342e-08 yes 3356 2.21774192766927e-10 4808 820824