SGTCid condition conc unit MRPS5|YBR251W.score MRPS5|YBR251W.strain.pval MRPS5|YBR251W.strain.significant MRPS5|YBR251W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_236 1509-0011 5.31 µM 15.183084801117 4.6510477239436e-37 yes 1 2.2886919647473e-52 98 3107280 SGTC_70 0141-0289 43.283 µM 9.13041849543444 1.3740064116535e-14 yes 2 3.41175024461717e-20 23 352408 SGTC_2526 patulin 37.61 µM 8.38408031277566 1.41043831139449e-12 yes 3 2.55619402678822e-17 14 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_310 1273-0058 1.06 µM 7.46827810285775 2.4613697372993e-10 yes 4 4.06254928041262e-14 104 2734232 SGTC_275 trichlorophene 5.69 µM 6.84705253770898 5.89492264447798e-09 yes 5 3.76935190650479e-12 95 62616 SGTC_1742 st038235 28.8875 µM 6.59848471047188 1.95190789367405e-08 yes 6 2.07690653983652e-11 31 564103 YBR002C RER2 SGTC_1597 7-benzyloxygramine 47.5 µM 6.49476916642969 3.17717909052031e-08 yes 7 4.15804103937126e-11 46 260807 SGTC_1251 0490-5699 265 µM 6.41066506496086 4.69129029629234e-08 yes 8 7.24430940854832e-11 6 3883818 SGTC_10 0279-0212 42.575 µM 6.10725553518853 1.83906568471906e-07 yes 9 5.06794452931172e-10 27 39851 YBR002C RER2 SGTC_2603 homopterocarpin 100 µM 5.88287769870836 4.85277351652916e-07 yes 10 2.01596933069958e-09 4 101795 A weak amylase inhibitor. SGTC_2250 alverine citrate 130 µM 5.62589239682406 1.41423761712109e-06 yes 11 9.2275683317338e-09 68 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_2177 5811945 192 µM 5.53017821639756 2.0826104349416e-06 yes 12 1.59952806934558e-08 9 5343475 SGTC_1834 st055981 52.8 µM 5.52749741923999 2.10512251415422e-06 yes 13 1.6241550213715e-08 9 471719 YDL150W RPC53 SGTC_1842 st055362 61.2 µM 5.50417442884471 2.31106568516167e-06 yes 14 1.85451094955711e-08 2 676032 SGTC_1150 3909-7983 10.9 µM 5.39373883379041 3.57762783728547e-06 yes 15 3.45032486853254e-08 5 23965914 SGTC_28 pentachloropyridine N-oxide 1.606 µM 5.38928634901429 3.64059394567703e-06 yes 16 3.53690096033099e-08 27 140250 A respiratory chain inhibitor. SGTC_596 1155-0152 116 µM 5.32933412745716 4.59869890691821e-06 yes 17 4.92867506265482e-08 13 280313 SGTC_173 1273-0061 2.693 µM 5.29649980579896 5.22108097966072e-06 yes 18 5.90217320143152e-08 135 2847414 YPL266W DIM1 SGTC_63 0099-0242 26.702 µM 5.15082967006772 9.08965232454827e-06 yes 19 1.29668319029228e-07 51 3898502 YLR359W ADE13 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 5.07517278805221 1.20552047882484e-05 yes 20 1.93572017879595e-07 16 5377381 SGTC_832 4083-0019 164 µM 5.06166498797854 1.26734213845269e-05 yes 21 2.07805427672445e-07 37 1990758 SGTC_2254 7938975 95.19 µM 5.01587515498141 1.50012073209855e-05 yes 22 2.63963013057545e-07 32 2969277 SGTC_2232 chlorophetanol 41.5365 µM 4.71783997098959 4.34465646646555e-05 yes 23 1.1918093400096e-06 90 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_195 4234-0266 16.654 µM 4.682470789727 4.90976059204907e-05 yes 24 1.41718793715425e-06 17 2303354 SGTC_503 tyrphostin 8 294 µM 4.63575490773849 5.76300675536743e-05 yes 25 1.77818578390816e-06 12 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2598 perillyl alcohol 100 µM 4.5802592562893 6.95824635354864e-05 yes 26 2.32199950619385e-06 18 10819 An apoptosis inducer. SGTC_1153 4055-0057 267 µM 4.57465877920527 7.09105291684019e-05 yes 27 2.38498373503681e-06 10 882706 SGTC_2460 5552655 174.22 µM 4.549163043869 7.7263843719996e-05 yes 28 2.69298507669031e-06 18 5401989 SGTC_1154 4088-0362 150 µM 4.45559492937893 0.000105472259774439 yes 29 4.18304329024943e-06 10 6618304 SGTC_1819 st053448 58.6 µM 4.45008365647246 0.000107404144017914 yes 30 4.29184233804593e-06 12 2857616 SGTC_211 3455-0679 143.504 µM 4.41227290145674 0.000121581314611464 yes 31 5.11455326822228e-06 11 748649 SGTC_2018 5133068 143 µM 4.34468398824713 0.000151390255225664 yes 32 6.97381506006872e-06 15 785362 SGTC_1164 k060-0068 93.7 µM 4.34205441147163 0.000152678003917205 yes 33 7.05782810470339e-06 16 5963676 SGTC_2611 pyromycin 23.93 µM 4.33977176896882 0.000153804162294812 yes 34 7.13153869138706e-06 18 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_629 3448-6466 76.7 µM 4.28205019949739 0.000185003179409393 yes 35 9.25895955222534e-06 12 573744 SGTC_2881 9058953 51.95 µM 4.22407925800491 0.000222217105413142 yes 36 1.19959805947146e-05 12 17122249 SGTC_2005 4024620 188 µM 4.20458956781012 0.0002362231692531 yes 37 1.30778174005697e-05 16 236743 SGTC_1446 4239-0190 62 µM 4.17613898397107 0.000258153180793737 yes 38 1.4824935170979e-05 29 1340085 SGTC_691 1548-0686 185 µM 4.14746628087849 0.000282162765679429 yes 39 1.68087480853722e-05 28 46495133 SGTC_1683 st010134 710 nM 4.09238792085252 0.000334220103457874 yes 40 2.13476810824394e-05 22 3818134 SGTC_2454 5-benzylidenerhodanine 10.36 µM 4.05425399573743 0.000375350614811445 yes 41 2.5147273225357e-05 35 1273210 SGTC_204 PMA1.184 62.41 µM 4.02894509855159 0.000405192383164825 yes 42 2.80138498849179e-05 28 2252213 YGL008C PMA1 SGTC_386 1509-0011 3.07 µM 3.99089135960218 0.000454227209745857 yes 43 3.29127151597015e-05 145 3107280 SGTC_1921 5740136 50 µM 3.98787326906889 0.000458342682939349 yes 44 3.33341294525408e-05 57 1774243 SGTC_614 0462-0418 107 µM 3.97869522525509 0.000471071147427609 yes 45 3.46472498890682e-05 27 5188303 SGTC_2302 7771753 200 µM 3.92170294749429 0.000557727230484913 yes 46 4.39626736373507e-05 44 2203047 SGTC_782 0083-0095 30.5 µM 3.82820448054339 0.000732378656825561 yes 47 6.45407483857038e-05 31 3591729 An indicator and reagent. SGTC_2403 6032726 181.2 µM 3.79126244458051 0.000814328986603518 yes 48 7.49417341405557e-05 41 2881040 SGTC_800 3448-7362 155 µM 3.7700244031064 0.000865182021768901 yes 49 8.16157929623437e-05 177 15991913 SGTC_68 0986-0284 82.829 µM 3.65304873783361 0.00120149411312519 no 50 0.000129572509926244 84 423278 YIL048W NEO1 SGTC_601 0986-0029 62.9 µM 3.63592747389203 0.0012597131324836 no 51 0.000138491129472663 50 24747981 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 3.56067043202529 0.00154746588865397 no 52 0.000184954562232449 28 7104 SGTC_19 0279-0214 38.434 µM 3.55289146630207 0.0015803957769784 no 53 0.000190510816285083 56 3566274 YBR002C RER2 SGTC_707 0865-0008 204 µM 3.51781526706003 0.00173695855824362 no 54 0.000217557576107746 14 723043 SGTC_368 fentichlor 4.58 µM 3.4829087873025 0.00190665279519445 no 55 0.000247998663193851 36 7329 A pesticide. SGTC_141 0443-0274 32.331 µM 3.45133021175635 0.00207300263115537 no 56 0.000278915307564885 68 1627241 SGTC_2593 nobiletin 86.24 µM 3.42528124581893 0.00222001781279914 no 57 0.000307081646589596 44 72344 An anti-infammatory. SGTC_1036 k216-0215 33.5 µM 3.42391062442756 0.00222800880773783 no 58 0.000308634591597682 75 622330 SGTC_1443 4112-3303 14 µM 3.4205820439466 0.00224752371381945 no 59 0.000312436422001503 16 704433 SGTC_3221 9128209 49.47 µM 3.41233996029318 0.00229651388760948 no 60 0.000322038670082411 28 16460723 SGTC_1289 0976-0073 69.1 µM 3.41041534385311 0.00230809201847669 no 61 0.000324320086169521 22 3391136 SGTC_1188 1403-0014 4.57 µM 3.40375311902278 0.00234858004943189 no 62 0.000332333992882669 78 9614867 SGTC_2339 9000433 200 µM 3.40294157963918 0.00235355566117703 no 63 0.000333322665609578 54 2988954 SGTC_1073 triclabendazole 3.09 µM 3.39566930879774 0.00239857022447084 no 64 0.000342305090283159 52 50248 An antihelmetic and likely tubulin inhibitor. SGTC_3274 9138298 49.47 µM 3.37000771213452 0.0025637059064037 no 65 0.00037583039976187 37 17015756 SGTC_365 0121-0052 13.6 µM 3.36288074104174 0.00261135724754746 no 66 0.000385668391331509 91 3101739 SGTC_330 1488-0319 80.1 µM 3.35670334407637 0.00265330548115307 no 67 0.000394388474705706 29 6846614 SGTC_2295 7971645 200 µM 3.35191815881879 0.00268621704177588 no 68 0.000401268696976811 47 2978226 YKL099C UTP11 SGTC_3352 9151559 45.5865 µM 3.30936256448891 0.00299552295099028 no 69 0.000467543307504037 27 17159339 SGTC_1447 4239-0816 81.9 µM 3.29403022814906 0.00311459722066511 no 70 0.000493809384612259 56 1341554 SGTC_2422 chlorphenesin carbamate 384.24 µM 3.26194963005799 0.00337762773532762 no 71 0.000553244012660798 66 2724 A muscle relaxant with antifungal properties. SGTC_850 0388-0143 75.9 µM 3.21775009386035 0.00377270928680651 no 72 0.000646001674327967 34 67273 SGTC_625 k213-0058 121 µM 3.2121365507926 0.00382574433366157 no 73 0.000658758682789438 177 3655420 SGTC_2310 7668677 200 µM 3.20267441339275 0.00391665378666964 no 74 0.000680789113842758 69 2197143 SGTC_1247 0448-0043 5.84 µM 3.19084588731854 0.0040330180008456 no 75 0.000709284632632321 93 3089013 YGL099W LSG1 SGTC_3008 9078912 71.4286 µM 3.18809437996962 0.00406052601889582 no 76 0.000716068915955063 41 16648731 SGTC_876 0720-0963 56.8 µM 3.18712079798346 0.00407029949486069 no 77 0.000718483731238871 42 765861 SGTC_701 4424-0219 185 µM 3.16182152568119 0.00433176605293607 no 78 0.000783928126865202 44 2911779 SGTC_531 3788-1495 174 µM 3.16163946304554 0.00433370085042587 no 79 0.0007844183681454 50 2896655 SGTC_767 0929-0023 86 µM 3.13976904683456 0.0045718156281245 no 80 0.000845405376371553 147 1204563 SGTC_1883 5-benzylidenerhodanine 20 µM 3.13554405560834 0.0046191388303206 no 81 0.000857678308430854 124 1273210 SGTC_1461 k072-0203 53.8 µM 3.13368202895682 0.00464013341047696 no 82 0.000863139047004453 41 5418714 SGTC_2688 kanamycin b 96.69 µM 3.12771493456218 0.00470798796549127 no 83 0.000880854785397319 510 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_168 3970-0862 530.542 µM 3.12187820995256 0.00477521492386602 no 84 0.000898506310054248 209 3135186 SGTC_2614 arthonioic acid 13.39 µM 3.09911673219324 0.00504563076468229 no 85 0.000970492642957913 53 6710684 SGTC_119 0121-0043 24.815 µM 3.09562751699858 0.00508826806640885 no 86 0.000981984525317924 189 1092378 SGTC_3206 9114350 49.47 µM 3.0700759371544 0.00541040018046777 no 87 0.00107002175831956 48 17087243 SGTC_456 gingerol 170 µM 3.06435318527717 0.00548498574282542 no 88 0.001090706067944 56 442793 A herb. SGTC_831 k061-1017 217 µM 3.04741385911028 0.0057111414248615 no 89 0.00115409836113432 121 1240153 SGTC_147 4466-0538 29.23 µM 3.0386775365086 0.00583098410064783 no 90 0.00118809524265997 73 6742687 YHR072W ERG7 SGTC_700 3453-2283 142 µM 2.99743995121425 0.00642730576751051 no 91 0.00136128744756619 74 565664 SGTC_1853 st056710 91.2 µM 2.99656414506411 0.00644053535060998 no 92 0.0013652039376279 67 269167 SGTC_862 0452-0056 10.2 µM 2.99643202497786 0.00644253319469154 no 93 0.00136579565411787 67 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_2058 5236698 133 µM 2.99092530589488 0.00652629183464247 no 94 0.00139066758336297 70 766665 SGTC_2750 bromebric acid 70.15 µM 2.97298622085318 0.00680586745768666 no 95 0.00147458845340851 91 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_778 3456-2434 196 µM 2.94300658855493 0.00729675372870375 no 96 0.00162520750297392 144 5539063 SGTC_1581 himbacine 57.9 µM 2.92726159662343 0.00756685831387404 no 97 0.0017098055915852 91 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1274 0865-0114 173 µM 2.90389214842958 0.00798399230265502 no 98 0.00184277548018437 65 870624 SGTC_908 3448-7491 47.7 µM 2.86246980665078 0.00877321463997789 no 99 0.0021017665451666 229 1203031 SGTC_995 3931-2021 34.6 µM 2.85663181234622 0.00888977405861211 no 100 0.00214081092011801 72 730143 SGTC_116 0155-0182 31.788 µM 2.83207589957893 0.00939503435602475 no 101 0.00231234348285693 183 771486 SGTC_2727 riluzole 51.77 µM 2.8229647752739 0.00958879542251272 no 102 0.0023790899539643 50 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1178 0988-0033 191 µM 2.81817424536687 0.00969206713689515 no 103 0.00241487958618277 103 5392207 SGTC_2565 isoliquiritigenin 100 µM 2.79980240551868 0.0100971809677137 no 104 0.00255669481271407 96 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_2361 9034121 116 µM 2.77448149900246 0.0106797035461089 no 105 0.00276448893838308 72 6496917 SGTC_1645 Cervolide 78 µM 2.7695648811129 0.0107961456899065 no 106 0.00280656117533312 49 23173 A fragrance. SGTC_1014 4130-3005 69.3 µM 2.76917313745965 0.0108054708650476 no 107 0.00280993810473201 88 743608 SGTC_3107 9121808 49.47 µM 2.75030130694466 0.0112630850614062 no 108 0.00297702441640375 42 662681 SGTC_2283 7944793 200 µM 2.7483366514958 0.011311679536188 no 109 0.00299492363864537 118 2970533 SGTC_161 4065-0411 162.148 µM 2.73336596855752 0.0116879904987983 no 110 0.00313453162874939 150 1906281 YLR208W SEC13 SGTC_3350 9150499 3.57 µM 2.73148542574767 0.0117360206286087 no 111 0.00315247647698119 133 4910996 YPR165W RHO1 SGTC_363 0455-0021 3.06 µM 2.72954802061708 0.0117856821111697 no 112 0.0031710605789773 152 4597466 SGTC_942 3253-1115 227 µM 2.72402188121595 0.0119283367292878 no 113 0.00322461167706814 99 46497897 SGTC_192 3455-0609 60.9 µM 2.72065682648015 0.0120159356935597 no 114 0.00325761796943495 71 3769639 SGTC_398 bronopol 33.3 µM 2.70128273581049 0.012531210189152 no 115 0.00345362962180658 91 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_1727 st034309 9.9045 µM 2.6952971111892 0.0126942245636889 no 116 0.0035162945896051 141 870305 SGTC_2365 9042475 200 µM 2.67316217400358 0.0133130954667783 no 117 0.00375699577179016 115 6464479 SGTC_1033 k072-0102 21.3 µM 2.6680208134084 0.0134605168285271 no 118 0.0038149765640723 104 5965931 SGTC_2495 cafestol 54.53 µM 2.66225535324915 0.0136275077632598 no 119 0.00388094851507492 106 16667697 An anti-infammatory. SGTC_2180 6301957 200 µM 2.65738819223152 0.0137698689857028 no 120 0.00393743535132277 46 845462 SGTC_1955 wogonin 32.4 µM 2.65219493022853 0.0139231812601658 no 121 0.00399851791439463 85 5281703 A flavanone. SGTC_2854 9024559 71.43 µM 2.65024121909789 0.0139812373092308 no 122 0.00402171600033558 98 3163529 SGTC_282 k297-0036 65.7 µM 2.64606523550615 0.0141060300034871 no 123 0.00407170551508756 54 5061378 SGTC_1841 st054148 70 µM 2.64362561148703 0.0141793775775502 no 124 0.00410116625458133 82 675442 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 2.63072984566236 0.0145725729784943 no 125 0.00426008671803427 110 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1077 5-fluorocytosine 377 nM 2.60750640333793 0.015304352764492 no 126 0.00456021823185108 85 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1228 0124-0032 52.5 µM 2.60706345182792 0.0153186116196211 no 127 0.00456612178544253 106 X1228 SGTC_1271 0832-2808 169 µM 2.6042191006094 0.0154104449809228 no 128 0.00460419345658731 93 3663794 SGTC_1847 st056231 15 µM 2.57063245245347 0.0165310660760595 no 129 0.0050756499954062 147 5393180 SGTC_1393 3470-5649 58.2 µM 2.56252866190557 0.0168116650560673 no 130 0.00519565051553747 76 4108395 SGTC_3005 9076496 71.4286 µM 2.55925790068041 0.0169260657875763 no 131 0.00524479451596709 66 21368410 SGTC_1944 st076371 56.9 µM 2.5531375938085 0.0171419231733413 no 132 0.00533786565712683 121 24208455 SGTC_396 dithiazanine 1.25 µM 2.54901940061058 0.0172884882448225 no 133 0.00540131452882693 58 10578 An antihelmenthic. SGTC_1901 st060216 58.6 µM 2.54836486472689 0.0173118812613473 no 134 0.00541146045417444 107 688792 SGTC_127 0180-0333 59.125 µM 2.53123850172713 0.0179336545966228 no 135 0.00568302667979022 179 771601 SGTC_1465 k213-0056 144 µM 2.52191549188134 0.0182800619713554 no 136 0.00583588723528942 115 24048857 YMR208W ERG12 SGTC_2434 5670830 169.91 µM 2.51977900866708 0.0183602435786796 no 137 0.0058714266890889 123 1549830 SGTC_1432 4049-0298 68.4 µM 2.51662987383085 0.0184789758574017 no 138 0.00592416119006702 86 741646 SGTC_1419 3993-2473 62.6 µM 2.48853969285761 0.0195672892097472 no 139 0.00641344589989872 103 704026 SGTC_1183 1254-0324 198 µM 2.48836576913706 0.0195741936463429 no 140 0.0064165835677191 103 5799357 SGTC_1238 0333-0287 48.8 µM 2.4763402160077 0.0200566279406316 no 141 0.00663685123432278 130 7226 SGTC_2191 5911152 200 µM 2.4711520347613 0.0202678578431065 no 142 0.0067339273863139 108 2875902 SGTC_1198 1612-1005 86.7 µM 2.45067788837577 0.0211199351919118 no 143 0.00712937438516451 111 6998509 SGTC_2974 9094440 9.66 µM 2.4392150951558 0.0216100827369572 no 144 0.00735960206740108 163 25236134 SGTC_929 2805-0021 398 µM 2.42254542679657 0.0223400056390127 no 145 0.00770609934592967 121 3098024 SGTC_480 am 92016 50 µM 2.41481062202816 0.0226856937898742 no 146 0.00787169638910847 101 2129 K+ channel blocker. SGTC_1776 st049249 45.9 µM 2.40131534410407 0.0232996276653197 no 147 0.00816812586533827 137 1822314 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 2.39828218538072 0.0234395218129261 no 148 0.00823608496671701 61 4620898 SGTC_2394 5221648 200 µM 2.38316692114681 0.0241472407498366 no 149 0.00858220471210039 156 788586 SGTC_2715 st079500 56.4 µM 2.3771849376502 0.0244322413777027 no 150 0.00872266954749599 104 28246688 SGTC_1910 st062352 60.4 µM 2.37106740124396 0.0247266152674012 no 151 0.00886839813600838 167 2245730 SGTC_436 n,n-dimethylsphingosine 3.3 µM 2.36487548874782 0.0250275922175771 no 152 0.00901806676766865 147 5282309 SGTC_206 4546-0025 72.014 µM 2.35930546718899 0.0253009584833928 no 153 0.00915458878177311 211 6620745 YIL048W NEO1 SGTC_2278 7948257 134.34 µM 2.35158564003795 0.0256839656397156 no 154 0.00934679294081129 121 1247028 SGTC_387 norethindrone acetate 66.7 µM 2.34974246526454 0.0257761261638333 no 155 0.00939320206803563 115 541197 SGTC_3031 9088762 49.47 µM 2.33240658090809 0.0266565562203169 no 156 0.0098396561181503 147 205253 SGTC_2884 9058502 51.95 µM 2.33009982456469 0.02677558031874 no 157 0.00990043785352316 158 6471554 SGTC_2694 st077685 81.9 µM 2.32608068376694 0.0269840202651996 no 158 0.0100071234067361 167 2838096 SGTC_1623 st003709 20.3 µM 2.32449199073747 0.0270667854270672 no 159 0.0100495701681595 246 16192618 SGTC_269 exalamide 29 µM 2.32338991808515 0.0271243237921234 no 160 0.010079107614473 102 3316 A derivative of salicylamide. SGTC_545 4218-0007 221 µM 2.32114627460141 0.027241778115356 no 161 0.0101394753155324 149 2840508 SGTC_2256 7954252 200 µM 2.31804680731618 0.0274047322889887 no 162 0.0102233886636219 91 2972920 SGTC_1458 k015-0034 6.33 µM 2.31622420202676 0.0275009345401852 no 163 0.0102730152066463 130 3598957 SGTC_1071 trifluoperazine 6.31 µM 2.31554989910268 0.0275365974309217 no 164 0.0102914285316253 147 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_3184 9108758 49.47 µM 2.31449222621594 0.027592613855979 no 165 0.0103203685915991 85 902885 SGTC_34 0469-0683 81.75 µM 2.31321179517756 0.0276605550561008 no 166 0.0103554986893732 142 3690923 SGTC_1519 esterone 74 µM 2.30713446268763 0.0279849296882094 no 167 0.0105236626301522 151 698 A steroid. SGTC_314 1671-0008 2.74 µM 2.30419569878771 0.0281429175535473 no 168 0.0106058302756403 215 3913060 SGTC_2342 7990637 118.86 µM 2.29909026284618 0.0284191510686908 no 169 0.0107499071563021 169 2033102 YER133W GLC7 SGTC_2956 9076196 2.52 µM 2.29868174523131 0.0284413513713575 no 170 0.010761508931272 144 16423868 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 2.29665402010343 0.0285517588441013 no 171 0.0108192571882876 187 6708561 SGTC_2187 6125751 200 µM 2.28597355206911 0.0291391990653022 no 172 0.0111279029352646 138 874498 SGTC_2706 st078239 82.5 µM 2.2848970831375 0.0291989593699149 no 173 0.0111594315592464 138 15434492 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 2.27938798812747 0.0295063933179326 no 174 0.0113220058637224 205 688664 SGTC_3035 9091303 49.47 µM 2.27914320355966 0.0295201155862174 no 175 0.0113292770115002 91 25237002 SGTC_2261 9010538 184.68 µM 2.27838227930722 0.029562805729814 no 176 0.0113519056335667 130 6457250 SGTC_1549 4'-methoxyflavonol 74.6 µM 2.27520059755483 0.0297418631135321 no 177 0.0114469495243708 121 97141 SGTC_2897 9048598 12.99 µM 2.27419580438077 0.0297985970650059 no 178 0.0114771082018498 124 6467404 SGTC_1313 1220-0047 237 µM 2.26667239476306 0.03022625262185 no 179 0.0117051229897712 194 3528706 SGTC_1021 4476-0760 85.3 µM 2.26563487315429 0.0302856259908564 no 180 0.0117368740330999 173 746768 SGTC_554 4483-2211 187 µM 2.26179429540784 0.0305062491692318 no 181 0.0118550577375332 148 747107 SGTC_1758 st042942 75.2445 µM 2.26075712971512 0.0305660572630739 no 182 0.0118871503128022 144 669317 SGTC_2807 7945238 51.95 µM 2.25696662989597 0.0307854628095066 no 183 0.012005080002227 183 17148797 SGTC_2749 bexarotene 57.39 µM 2.24580928564088 0.0314388621004063 no 184 0.0123581131446183 188 82146 An retinoic acid receptor inhibitor. SGTC_2568 diosmetin 100 µM 2.24334149989905 0.0315849189929827 no 185 0.012437400583119 171 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_134 0269-0018 6.916 µM 2.24323819051438 0.0315910456100725 no 186 0.0124407293935906 290 4378915 SGTC_720 r052-1644 49.9 µM 2.24278119838544 0.0316181586655954 no 187 0.0124554637424417 141 1422863 YOR257W CDC31 SGTC_1111 tnp00062 510.699 nM 2.24169976534102 0.0316823960139425 no 188 0.0124903915331382 131 676306 SGTC_2785 7756463 72.73 µM 2.23948641739465 0.0318142055930886 no 189 0.0125621420560751 150 2201551 SGTC_661 1304-0007 33.6 µM 2.23575883577399 0.0320372147374224 no 190 0.0126837863570505 147 3117130 SGTC_496 calpeptin 138 µM 2.23323853448626 0.032188726390546 no 191 0.0127666092136057 148 73364 A calpain inhibitor. SGTC_2194 5927483 104.545 µM 2.23197600331551 0.032264847399204 no 192 0.0128082744854945 158 760979 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 2.22880277381148 0.0324568251123846 no 193 0.0129135151574714 167 6708514 SGTC_2472 5377652 49.4 µM 2.20990865037127 0.0336195051804426 no 194 0.0135557513843029 230 1610903 SGTC_462 ag-879 158 µM 2.20674373558351 0.033817575403056 no 195 0.0136659839324562 197 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_2903 5923464 63.88 µM 2.19619524018036 0.0344846762042444 no 196 0.0140389859616434 113 2876576 SGTC_2682 pyrogallin 40.03 µM 2.19277064557806 0.0347035628859743 no 197 0.0141619539442535 205 822798 An ATP competetive kinase inhibitor. SGTC_2160 5660466 132.927 µM 2.18995423528374 0.0348844306607758 no 198 0.0142637780079748 156 2859134 SGTC_1396 3511-0007 98.6 µM 2.1866679132966 0.0350964533282933 no 199 0.0143833878075165 152 X1396 SGTC_118 0083-0097 135.343 µM 2.16721006755535 0.0363735734358624 no 200 0.0151094200416506 437 5207356 SGTC_1802 st050112 57.9 µM 2.16512736960215 0.036512497159754 no 201 0.0151889662508447 159 4662563 SGTC_1210 3013-0140 750 nM 2.15402522439041 0.0372603948580944 no 202 0.0156190969105941 136 905973 SGTC_2510 benzyl isothiocyanate 8.31 µM 2.1493070835707 0.0375820005751043 no 203 0.0158050326861165 158 2346 DNA damaging agent; causes G2/M arrest. SGTC_2791 5663188 71.43 µM 2.1476156222613 0.0376978472376523 no 204 0.0158721516697671 177 54690634 SGTC_2204 7233102 200 µM 2.13838659872063 0.0383350792674907 no 205 0.0162426896189218 120 2172480 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 2.13814529178601 0.0383518577623119 no 206 0.0162524764778482 206 688667 SGTC_1523 st012844 44.7 µM 2.1058338562139 0.0406531788984574 no 207 0.0176093934101721 205 4274103 SGTC_1545 lovastatin 49.4 µM 2.10397498240699 0.0407889116808784 no 208 0.0176903146842174 226 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_1663 st014140 55.4 µM 2.10250807131932 0.0408962831898712 no 209 0.0177543966821904 212 4207120 SGTC_392 N-ethylmaleimide 8.33 µM 2.09934193112217 0.0411288124284057 no 210 0.017893384805257 173 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_2428 5615643 7.78 µM 2.09091711411656 0.0417527768946015 no 211 0.0182677473382043 195 2253075 SGTC_1429 4049-0205 9.46 µM 2.08010062958019 0.0425650909345881 no 212 0.0187581519370394 197 22774478 SGTC_1336 1486-0901 104 µM 2.0788078574387 0.0426630268667528 no 213 0.0188175072040133 193 5006114 SGTC_2720 fluspirilene 36.88 µM 2.0724644405234 0.0431462252878041 no 214 0.0191110745731122 148 3396 An atypical antipsychotic. SGTC_148 3253-0744 288.01 µM 2.07012130712124 0.0433258234148583 no 215 0.0192204930215074 192 6893655 SGTC_2144 5628481 200 µM 2.06546981754675 0.0436841424820231 no 216 0.0194392842459402 194 2818399 SGTC_2674 ligustilide 100 µM 2.05156618210429 0.0447694580692111 no 217 0.020105920794665 147 5319022 A signalling regulator. SGTC_1147 3809-1045 12.3 µM 2.04376615021875 0.0453877711121709 no 218 0.0204883273399847 225 325925 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 2.03823044010234 0.0458307429408565 no 219 0.0207634463096203 244 23665772 A membrane-active detergent. SGTC_1692 fluoroquinolonic acid 71 µM 2.03555715290817 0.0460459020274843 no 220 0.0208974220026686 164 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 2.02952946017649 0.0465340176173649 no 221 0.0212021957366619 196 4213774 SGTC_1122 capsaicin 818.572 nM 2.02223000269144 0.0471306692566035 no 222 0.0215762980490257 213 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_489 paxilline 115 µM 2.01900813965837 0.0473959652766038 no 223 0.0217431867514566 190 105008 A toxic potassium channel blocker. SGTC_421 streptovitacin 30 mM 2.01716853371685 0.0475479787339884 no 224 0.0218389642998317 243 91467 include heat shock SGTC_1881 5652484 16 µM 2.01600396393093 0.0476444131636762 no 225 0.0218997806461007 231 2255129 SGTC_2364 9055074 200 µM 2.01440201261771 0.0477773216777059 no 226 0.0219836716168134 209 6470630 SGTC_493 zm226600 134 µM 2.00850815088068 0.0482688728095852 no 227 0.0222946603884019 216 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1943 st076331 65.2 µM 2.0052311330675 0.0485439229269549 no 228 0.0224691716063882 205 24208415 SGTC_210 3551-0445 56.827 µM 2.0025902483679 0.0487664911313036 no 229 0.0226106437126037 241 2865180 YOR207C RET1 SGTC_944 3370-0224 231 µM 2.00046905094099 0.0489458511879188 no 230 0.0227248193102327 222 4580514 SGTC_897 1000-0139 31.4 µM 1.99557331555891 0.0493618273782016 no 231 0.0229901932448841 187 6151020 SGTC_993 3909-8757 62.7 µM 1.99285764643405 0.0495937839376749 no 232 0.0231385186207274 190 4288324 YLR208W SEC13 SGTC_1440 4100-1550 40 µM 1.99034079299061 0.049809534687496 no 233 0.0232767036101496 141 742806 SGTC_1184 1269-1718 139 µM 1.9816823465896 0.0505574810888601 no 234 0.0237574021185993 201 5403821 SGTC_2113 5491891 107.031 µM 1.98124638998621 0.0505953758260255 no 235 0.0237818245901453 255 789979 SGTC_1702 st027038 51 µM 1.97553111239684 0.0510942613218376 no 236 0.0241039537409267 225 5521182 SGTC_3267 9137951 49.47 µM 1.97231506671033 0.0513767058920765 no 237 0.0242868253596229 140 16643986 SGTC_2696 st077691 74.316 µM 1.96916679859831 0.0516543995222941 no 238 0.0244669700783626 211 757133 SGTC_645 0845-0943 5.41 µM 1.96730319064126 0.0518193408480806 no 239 0.0245741337208607 204 1885106 SGTC_1793 st048256 72.231 µM 1.96524199075856 0.0520022575574222 no 240 0.0246931180246239 164 672022 SGTC_830 4076-0286 57.8 µM 1.96166686128872 0.0523207408336795 no 241 0.024900641198678 405 6866659 SGTC_159 3970-0959 50 µM 1.95569976580339 0.0528557553598185 no 242 0.0252502661747737 447 6615653 SGTC_2245 6637752 200 µM 1.95510987328442 0.0529088804620357 no 243 0.0252850515780482 162 681890 SGTC_3046 9092212 49.47 µM 1.95296601258766 0.0531023110553185 no 244 0.0254118113089404 187 25236637 SGTC_2975 9084847 53.72 µM 1.94556639890411 0.0537742544342483 no 245 0.0258534232594387 258 27211724 SGTC_3109 9122853 49.47 µM 1.94556212701869 0.0537746442909352 no 246 0.0258536800502719 198 1234709 SGTC_2940 9060638 45.86 µM 1.94470487479116 0.053852923320527 no 247 0.0259052542516238 260 4027022 SGTC_1166 k206-0078 225 µM 1.93698529305163 0.0545618992940231 no 248 0.0263735705785188 269 5404595 SGTC_104 0074-0074 590.992 µM 1.92934851680115 0.0552705130066955 no 249 0.0268438052227914 129 3943124 SGTC_3290 9121031 71.43 µM 1.91789910290705 0.0563464942916399 no 250 0.0275619030105456 205 17014854 SGTC_407 eburnamonine 100 µM 1.91638963975708 0.0564895726858116 no 251 0.0276577592714618 211 3195 SGTC_1221 2958-7315 257 µM 1.91558782912268 0.056565690745103 no 252 0.02770878998034 248 4562705 SGTC_237 nikkomycin 200 µM 1.91437853742192 0.0566806449210689 no 253 0.0277859029456838 254 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_1032 k061-1018 98.7 µM 1.91236954897965 0.0568720242863585 no 254 0.0279144054523807 295 4005393 SGTC_1254 0550-0035 264 µM 1.90965356183701 0.0571315620308198 no 255 0.0280889169195954 264 15121435 SGTC_1473 k844-0725 134 µM 1.90757260846821 0.0573310465040139 no 256 0.0282232391217269 272 54682906 SGTC_1865 st057639 52.2 µM 1.90619037212516 0.0574638531756746 no 257 0.0283127554612014 236 688818 SGTC_133 0724-0033 378.92 µM 1.90132137520814 0.0579335999238618 no 258 0.0286299654782274 228 280309 SGTC_479 n-linoleoylglycine 10 µM 1.90074529038406 0.0579893780349677 no 259 0.0286676915928654 196 6433346 An anti-infammatory. SGTC_423 5-fluorouracil 457 µM 1.89888382780051 0.0581698985068814 no 260 0.0287898760634858 254 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1329 1447-1697 50.6 µM 1.89643718099031 0.0584078400233234 no 261 0.0289511296403898 261 2840515 SGTC_3243 9134147 49.47 µM 1.89581399078401 0.058468568550707 no 262 0.028992322592207 163 24282180 SGTC_2853 9015042 58.44 µM 1.88932650541498 0.0591037083783501 no 263 0.0294240460307151 214 6457456 SGTC_2992 9074591 71.4286 µM 1.88756275287022 0.0592773161566189 no 264 0.0295423372077277 213 17741321 SGTC_1839 st053978 48 µM 1.88555754172757 0.0594751763657457 no 265 0.0296773017296197 250 3788398 SGTC_1857 st056007 79.3 µM 1.88544647589168 0.0594861506780759 no 266 0.0296847921558095 197 619834 SGTC_446 go6976 132 µM 1.88167286912583 0.0598599612160374 no 267 0.0299402228158304 210 3501 A protein kinase C inhibitor. SGTC_549 1661-1316 519 µM 1.87852934597386 0.0601727588409687 no 268 0.0301543932021508 260 2857282 SGTC_1764 st044502 93.5 µM 1.87588638075026 0.0604367371862749 no 269 0.030335441580064 280 8407 SGTC_727 3032-0951 202 µM 1.87516384470753 0.0605090613116198 no 270 0.0303850932290523 246 3652836 SGTC_1471 k673-0312 37 µM 1.87456620939214 0.0605689343282644 no 271 0.0304262127428395 219 24099884 SGTC_84 0443-0269 128.823 µM 1.87359951486006 0.0606658789810471 no 272 0.0304928224840146 270 6150058 SGTC_1298 1079-1278 263 µM 1.86716301555599 0.0613144587562397 no 273 0.0309394133226957 261 2840950 SGTC_2325 6158266 200 µM 1.86713162537142 0.0613176350393845 no 274 0.0309416044960081 260 3623240 SGTC_820 1582-0060 59.9 µM 1.86529896674517 0.0615032994738777 no 275 0.0310697549558858 290 3848840 SGTC_698 k064-0052 127 µM 1.86399271742902 0.0616359018089926 no 276 0.0311613635213624 170 5088751 SGTC_2276 7947513 42.08 µM 1.8578238801499 0.0622651426216284 no 277 0.0315970143956443 255 2105100 SGTC_527 4476-4215 268 µM 1.85540503121832 0.062513235979654 no 278 0.0317692047373386 285 4418754 SGTC_3334 9142812 21.919 µM 1.85421690886151 0.0626353796814436 no 279 0.0318540669769793 266 45283678 SGTC_2087 5276107 200 µM 1.8514222660633 0.0629234134015786 no 280 0.0320544141293713 257 144405 SGTC_912 3474-0017 2.18 µM 1.84781649988258 0.0632965700235716 no 281 0.0323144465732478 274 3360550 SGTC_2118 5526350 200 µM 1.84395849028447 0.0636977364958483 no 282 0.0325945949329148 270 743594 SGTC_878 0828-0289 13.7 µM 1.84351253227667 0.0637442356940827 no 283 0.0326271068260034 348 745350 YLR208W SEC13 SGTC_219 mitoxanthrone 164.414 µM 1.84129060008768 0.063976306000182 no 284 0.0327894922460312 286 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2168 5727979 200 µM 1.83976256751545 0.0641362826621781 no 285 0.032901551628638 234 695210 SGTC_755 1995-0008 37.3 µM 1.83651682218969 0.0644771261456645 no 286 0.0331406282349773 246 689533 SGTC_599 1935-0052 86.5 µM 1.83380221309992 0.0647632730062907 no 287 0.0333416795565252 285 9557311 SGTC_2624 nerol 100 µM 1.83091752262565 0.0650684278299434 no 288 0.0335564272513926 229 637566 A natural product oil. SGTC_186 3455-3465 67.277 µM 1.8306039172568 0.0651016694789713 no 289 0.0335798417277306 156 755278 SGTC_900 1112-0045 141 µM 1.81935067280208 0.0663032376448156 no 290 0.0344289735670859 199 56211 YIL048W NEO1 SGTC_842 0271-0008 11.1 µM 1.81625410089847 0.0666368698784639 no 291 0.0346657012751947 288 1221709 SGTC_799 1310-0557 151 µM 1.81548476010094 0.0667199617102967 no 292 0.0347247229455255 302 5354492 SGTC_2521 angolensin 13.4 µM 1.8089263415905 0.0674315552025934 no 293 0.0352312237202344 238 821428 A flavenoid. SGTC_1765 st044815 90.4 µM 1.80646033535476 0.0677006311109628 no 294 0.0354232322219528 289 645695 SGTC_440 fluspirilene 35.1 µM 1.80589016091863 0.0677629630512029 no 295 0.0354677491412689 293 3396 An atypical antipsychotic. SGTC_2468 5987765 72.9 µM 1.79679730714191 0.0687630020999031 no 296 0.0361839020192367 282 26772094 SGTC_283 0987-0079 11.7 µM 1.79294231053578 0.0691903969830359 no 297 0.0364910745049953 323 411556 SGTC_1627 st003713 25.6 µM 1.79221242716635 0.0692715474848552 no 298 0.0365494723773999 407 16195070 YER133W GLC7 SGTC_582 0987-0078 156 µM 1.79172252440421 0.0693260573735635 no 299 0.0365887123014264 422 1625765 SGTC_1516 st013856 110 µM 1.78897635960361 0.0696322261293826 no 300 0.0368093114388875 260 5281404 A mutagen and neurotoxin. SGTC_1833 st055984 71 µM 1.78502534919122 0.0700745475532841 no 301 0.0371286026239993 268 676288 SGTC_3314 9135860 59.4275 µM 1.78223908772107 0.0703877710133408 no 302 0.0373551255658745 276 25252478 SGTC_279 1273-0055 2.93 µM 1.7816581139805 0.0704532178272099 no 303 0.0374025006599056 301 2847562 SGTC_523 1934-0222 13.7 µM 1.77961127622533 0.0706841673228564 no 304 0.0375697997567774 315 1361595 SGTC_1621 st003705 32.4 µM 1.77520182221039 0.0711836725414962 no 305 0.0379322844870632 333 24207032 SGTC_2125 5246583 200 µM 1.77507768251247 0.0711977742743411 no 306 0.0379425307026418 363 835267 SGTC_1290 0986-0249 10.2 µM 1.77434798633965 0.071280707965789 no 307 0.0380028038651249 241 53329 SGTC_2347 9049783 174.81 µM 1.76815128323802 0.0719879866329806 no 308 0.0385178079970854 348 6467988 YPL169C MEX67 SGTC_2077 5212015 200 µM 1.76809988414777 0.0719938756363138 no 309 0.0385221034109052 312 780900 SGTC_2231 micatex 6.853 µM 1.76800380425263 0.0720048848921856 no 310 0.0385301338394308 244 20737 An antifungal of unknown mechanism. SGTC_1361 1608-0041 5.61 µM 1.76349819989157 0.072522607646126 no 311 0.0389082503102386 301 X1361 SGTC_526 4469-0568 170 µM 1.76000162099919 0.0729263482863271 no 312 0.0392037658652654 313 2901964 SGTC_1978 st071761 42 µM 1.75316560123074 0.0737206522997913 no 313 0.0397867928506096 282 5147680 SGTC_2961 9083290 32.55 µM 1.74887676274201 0.0742223549375318 no 314 0.0401561620510805 270 17741490 SGTC_1462 k081-0014 26.5 µM 1.74800591766362 0.0743245429963587 no 315 0.0402315013627872 199 3270634 SGTC_1052 3253-3998 198 µM 1.74589443000288 0.0745727584709044 no 316 0.0404146489698242 353 5450317 SGTC_1755 st041960 45.185 µM 1.74224512250582 0.0750032430546009 no 317 0.0407327807211384 292 2257073 SGTC_420 mitomycin C 81.9 mM 1.74011296145507 0.075255635661275 no 318 0.0409195923815432 326 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_602 3130-1533 38.1 µM 1.73904317568234 0.0753825142578799 no 319 0.0410135843493818 352 720941 SGTC_1007 4101-0031 70 µM 1.73779591714272 0.0755306472417765 no 320 0.0411233901758092 319 1146276 SGTC_1732 st034308 51.822 µM 1.73471910064629 0.0758970195015481 no 321 0.0413952857105927 321 830119 SGTC_404 fumagillin 50 µM 1.72599557941438 0.0769431315902461 no 322 0.0421741040130849 336 12015870 A methionine aminopeptidase binder. SGTC_2139 5578692 56.4705 µM 1.71991037558331 0.0776793249485185 no 323 0.042724367111675 273 650991 YMR113W FOL3 SGTC_281 1672-3440 14.9 µM 1.71960804959666 0.0777160395685692 no 324 0.0427518559889686 312 6833000 SGTC_1001 4048-4355 44.4 µM 1.71689871402162 0.0780456508394945 no 325 0.0429988399576618 316 21824233 SGTC_3123 9126162 49.47 µM 1.71176028241386 0.0786736917111914 no 326 0.043470427127584 297 25239884 SGTC_3165 9101544 49.47 µM 1.710367156554 0.0788446236505723 no 327 0.0435990002023567 323 5002184 SGTC_2945 9067681 61.76 µM 1.70965664478185 0.0789319093676398 no 328 0.0436646921708776 282 16456930 SGTC_947 3447-0010 211 µM 1.7045114214076 0.0795661809205116 no 329 0.0441427920645724 299 748350 SGTC_212 3807-4682 38.772 µM 1.70338335233499 0.0797057564037291 no 330 0.0442481755441814 456 3125501 YBL034C STU1 SGTC_3104 9120930 49.47 µM 1.70324786467164 0.0797225326831131 no 331 0.0442608463428427 269 17014836 SGTC_1662 st014054 52 µM 1.69977493826991 0.0801534677569846 no 332 0.0445866336562187 257 2838777 SGTC_66 0109-0187 42.4 µM 1.69785138387037 0.0803929068193208 no 333 0.0447679074720461 337 759417 SGTC_3282 9108498 15.4605 µM 1.69427012652758 0.0808401315984866 no 334 0.0451069822468798 341 16459645 SGTC_2731 amoxapine 43.43 µM 1.69318137793968 0.0809764653600901 no 335 0.0452104740412767 161 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2534 helenine 20.12 µM 1.6918463469686 0.081143875539361 no 336 0.0453376370488751 277 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_3044 9093193 49.47 µM 1.68421891900234 0.0821053515082379 no 337 0.046069684135265 369 25236277 SGTC_1302 1159-0335 255 µM 1.68155089411717 0.0824436878855828 no 338 0.0463279798061921 310 649284 SGTC_1682 st012968 530 nM 1.67978796900262 0.0826678224154126 no 339 0.0464992883943632 288 24207270 SGTC_1909 st060837 51.5 µM 1.67814536792392 0.0828770716246799 no 340 0.0466593619484089 358 678937 SGTC_871 0574-0004 149 µM 1.67433381018682 0.0833641566591745 no 341 0.0470325066266639 376 9551173 SGTC_675 1309-0189 238 µM 1.66978448753847 0.0839483350563218 no 342 0.0474810053114854 322 4246530 SGTC_2556 citropten 84.59 µM 1.66288671737105 0.0848399337514 no 343 0.0481675568475917 383 2775 A potential DNA crosslinker. SGTC_1953 st076800 12.1 µM 1.65880947233683 0.0853702824219347 no 344 0.0485770955008981 390 297591 SGTC_811 0416-0114 265 µM 1.64376489955862 0.0873487048545444 no 345 0.0501123871759488 334 6612453 SGTC_55 0767-0285 6.563 µM 1.64127570515586 0.0876793176431333 no 346 0.0503700984427693 412 3116166 SGTC_1590 st077108 57.8 µM 1.64124354742297 0.0876835949073094 no 347 0.0503734346941433 305 5489485 SGTC_2233 sulbentine 40.3845 µM 1.63949441786407 0.0879164792590089 no 348 0.0505551661410641 405 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2589 lobaric acid 100 µM 1.63322353707508 0.0887551948504018 no 349 0.0512109957184012 365 73157 A novel microtubule depolymerizer. SGTC_741 4582-0002 126 µM 1.63137422742324 0.0890036697437393 no 350 0.0514056898109728 345 2912688 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.63096920779718 0.0890581575946874 no 351 0.0514484084961855 376 5393153 SGTC_1439 4092-1168 46 µM 1.63042420127916 0.0891315172529441 no 352 0.05150593658735 332 2886240 SGTC_1615 st002656 86.5 µM 1.62899576372663 0.0893240029948952 no 353 0.0516569578741922 333 1584458 SGTC_2019 4016004 108 µM 1.62782493588165 0.0894820056300388 no 354 0.0517810057721492 313 45595336 SGTC_472 calcifediol 10 µM 1.62772651991635 0.0894952962801934 no 355 0.0517914436114464 280 5283731 A vitamin D metabolite. SGTC_1824 st053723 68.6 µM 1.62587163441356 0.0897460652049797 no 356 0.0519884827405044 371 675225 SGTC_2097 5376186 200 µM 1.62239176545829 0.0902179303359004 no 357 0.0523597455968209 382 742755 SGTC_2086 5274770 176.623 µM 1.61815377886839 0.0907950808424945 no 358 0.0528147305413924 355 689278 SGTC_2026 5148700 152 µM 1.61439544512708 0.091309198037879 no 359 0.0532208395384742 354 79838 SGTC_3223 9129970 49.47 µM 1.61418073628087 0.0913386339408029 no 360 0.0532441145741668 387 17248386 SGTC_2845 9003024 42.97 µM 1.61058658425113 0.0918324258198221 no 361 0.0536349299099251 395 2990173 SGTC_1428 4049-0204 61.7 µM 1.6099261538005 0.0919233754156733 no 362 0.0537069892919259 363 X1428 SGTC_2328 6201408 200 µM 1.60959777279145 0.0919686224420443 no 363 0.0537428473829234 348 2890418 SGTC_2290 7904846 200 µM 1.60543061999219 0.0925442402271956 no 364 0.0541995351648171 382 2962154 SGTC_2966 9084041 48.03 µM 1.60456105484789 0.0926646905184933 no 365 0.0542952189595351 363 17741380 SGTC_2142 5622915 118.518 µM 1.60374773817556 0.0927774543016026 no 366 0.0543848342887919 320 5322196 SGTC_2120 5538279 151.968 µM 1.60353434674245 0.0928070571464491 no 367 0.0544083661986538 360 2058197 SGTC_385 1494-0393 12.4 µM 1.60321167617107 0.0928518330650209 no 368 0.0544439642488502 378 3090647 SGTC_150 3970-0969 77.2 µM 1.60279158441322 0.092910151728777 no 369 0.0544903377186183 460 6615640 SGTC_2426 5582046 32.21 µM 1.60199217252256 0.0930212037819599 no 370 0.0545786702062326 390 2251934 SGTC_2081 5214970 32.255 µM 1.60107984735045 0.0931480612778111 no 371 0.0546796175669941 350 2063512 SGTC_1163 k060-0048 49.9 µM 1.59792565217571 0.0935876326639613 no 372 0.0550297621756807 408 6809982 SGTC_2162 5663267 200 µM 1.5951774583928 0.0939718704705454 no 373 0.0553362790131642 345 6456493 SGTC_791 1348-1292 225 µM 1.59157049787592 0.0944779414691337 no 374 0.055740621685979 462 5437054 SGTC_892 0929-0076 29 µM 1.58607205493985 0.0952532570125803 no 375 0.0563614826034643 437 5751038 SGTC_1887 st057648 70.8 µM 1.58323019134303 0.0956558095996638 no 376 0.0566845037196508 370 688672 SGTC_766 1391-0721 126 µM 1.57288099695555 0.0971323622412861 no 377 0.0578731880229593 379 1020919 YIL115C NUP159 SGTC_2094 5332512 191.667 µM 1.57055607619776 0.097466354972321 no 378 0.0581428996805751 386 755774 SGTC_630 4356-0227 183 µM 1.5662758003277 0.0980834510594916 no 379 0.0586420319081028 355 779312 SGTC_214 4373-3496 70 µM 1.56096865286178 0.0988525623789102 no 380 0.059265573642311 546 3779166 SGTC_631 k072-0230 41.5 µM 1.55952465136212 0.0990625885984568 no 381 0.0594361273318301 420 5773147 SGTC_1695 st026914 34.495 µM 1.55887818458653 0.0991567211870822 no 382 0.0595126072934194 379 3289191 SGTC_3187 9109394 49.47 µM 1.55641828690301 0.0995155070526432 no 383 0.059804329747121 409 17098090 SGTC_1539 benzyladenosine 56 µM 1.55439226580913 0.0998117220971087 no 384 0.0600454384832569 352 92208 A nucleotide analog. SGTC_2203 7227154 166.4 µM 1.55087192009941 0.100327946241209 no 385 0.0604661904317004 347 896304 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 1.54909528180722 0.100589211434838 no 386 0.0606794084766627 338 17037758 SGTC_914 3820-6779 408 µM 1.54759754249973 0.100809848154664 no 387 0.0608596117325643 387 2893481 SGTC_2832 7992762 51.95 µM 1.54754565860399 0.100817497654861 no 388 0.0608658617295758 354 2985177 SGTC_3036 9090181 49.47 µM 1.54405092845502 0.101333717902525 no 389 0.0612879976856035 339 25236586 SGTC_901 1112-0062 60.1 µM 1.54389110390463 0.101357372174031 no 390 0.0613073577977093 369 1908457 SGTC_3102 9121669 49.47 µM 1.5416926375665 0.1016831567764 no 391 0.061574150948966 326 41905072 SGTC_1444 4112-3581 28 µM 1.54104794731845 0.101778836039727 no 392 0.061652558502379 380 2877249 SGTC_163 TUB2.036 7.546 µM 1.54079364663288 0.101816595132727 no 393 0.061683508112053 582 15992207 YJR013W GPI14 SGTC_3088 9117578 49.47 µM 1.53956885045886 0.101998598236866 no 394 0.061832741603183 360 678341 SGTC_476 mead acid 10 µM 1.53590363685503 0.102544658220064 no 395 0.0622810080252684 296 5312531 An omega 9 fatty acid. SGTC_3189 9110682 49.47 µM 1.53496643132643 0.102684627886121 no 396 0.0623960369654208 399 17122418 SGTC_327 1273-0057 3.96 µM 1.53326865293555 0.102938541025809 no 397 0.0626048374463526 381 3108138 SGTC_2643 anethole 100 µM 1.53186993979195 0.103148069572929 no 398 0.0627772663782228 418 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1190 1486-1332 13 µM 1.53167464304385 0.10317734983424 no 399 0.0628013713587374 392 4150046 SGTC_965 1291-5240 308 µM 1.53083072118163 0.103303945927116 no 400 0.0629056174148037 419 2834598 SGTC_1614 st002383 48.6 µM 1.52963232929832 0.103483909521989 no 401 0.0630538812158279 413 1947235 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.52952655967837 0.103499803962605 no 402 0.0630669799835806 450 5379071 SGTC_3140 9094243 49.47 µM 1.52764714510779 0.103782526915572 no 403 0.0633000848422532 415 19291112 SGTC_177 1327-0068 8.361 µM 1.52550009878425 0.104106195175905 no 404 0.0635672044652608 430 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_1466 k213-0079 57.5 µM 1.52504278228853 0.104175230295851 no 405 0.0636242135534304 424 3657981 SGTC_530 4358-1714 28 µM 1.52398562130842 0.104334943143271 no 406 0.0637561515416581 480 1564641 SGTC_1515 3460-0031 42.1 µM 1.52365532057723 0.104384880394176 no 407 0.0637974180240072 342 2876596 SGTC_38 0929-0051 58.268 µM 1.52335485298404 0.104430322297736 no 408 0.0638349753140732 449 1379719 SGTC_2865 9030313 51.95 µM 1.51827757595921 0.105200364532551 no 409 0.0644722190899232 386 42562754 SGTC_3356 9151811 4.48 µM 1.50791711421959 0.106784406514874 no 410 0.065787870946549 402 1859254 YPR165W RHO1 SGTC_839 0122-0028 230 µM 1.50557494288867 0.107144881076641 no 411 0.066088162442827 487 759448 SGTC_2326 6164455 177.58 µM 1.50354190082716 0.10745848948806 no 412 0.0663496801943958 403 2888790 SGTC_1319 1306-0155 43.7 µM 1.50066291586395 0.107903720414614 no 413 0.0667213846802725 475 3122360 SGTC_2838 9002687 71.43 µM 1.49738987129996 0.108411504028199 no 414 0.0671459211223682 391 6457060 SGTC_2824 7998404 51.95 µM 1.49356505899584 0.109007065324653 no 415 0.067644668879058 392 837851 SGTC_516 3992-2719 87.3 µM 1.48918013160062 0.109692731254334 no 416 0.0682199706290191 384 5350887 YDR037W KRS1 SGTC_1496 4469-0713 57.4 µM 1.48790795085708 0.109892238887176 no 417 0.0683875852958642 419 746691 SGTC_1222 0366-0074 1.18 µM 1.48740482618075 0.109971212393975 no 418 0.0684539615065373 443 286520 SGTC_1622 st003707 19.4 µM 1.48423661194806 0.110469450282711 no 419 0.0688730800256973 479 10140899 SGTC_2446 5162541 200 µM 1.48414438661172 0.110483977971098 no 420 0.0688853099485122 411 1549321 SGTC_761 k216-0224 480 µM 1.48073694986893 0.111021690923973 no 421 0.0693383418193422 452 1340404 SGTC_1528 arabinosylhypoxanthine 74.6 µM 1.47207931292157 0.112396339931864 no 422 0.0704997305627577 482 804 An inhibitor of viral and cellular DNA polymerases. SGTC_174 3553-0389 74.3 µM 1.47004581970018 0.112720971634539 no 423 0.0707746723856652 386 738071 SGTC_1273 0849-0096 14.1 µM 1.46896449661051 0.112893869047227 no 424 0.0709212096077282 454 5286025 SGTC_2477 5967686 25.23 µM 1.46879222644911 0.11292143153942 no 425 0.0709445765803309 446 776118 SGTC_3286 9117135 37.221 µM 1.46843346211147 0.112978847722949 no 426 0.0709932588728971 441 3438150 SGTC_2721 ifenprodil 61.44 µM 1.46722401715552 0.113172559253617 no 427 0.0711575627712774 427 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1575 cyproterone acetate 48 µM 1.46620711933181 0.113335614642624 no 428 0.0712959348334669 432 9880 An androgen receptor antagonist and liver toxin. SGTC_1864 st057645 30.4 µM 1.46262734086317 0.113910950466072 no 429 0.0717846888666081 389 688666 SGTC_405 ebelactone b 50 µM 1.45840746781216 0.114591830037487 no 430 0.0723641317448883 465 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2771 fluoxetine 41.05 µM 1.45805701920634 0.114648505157793 no 431 0.0724124135555673 413 3386 A selective serotonin reuptake inhibitor. SGTC_3323 9138564 53.9225 µM 1.45000545213896 0.11595611498267 no 432 0.0735284994178302 498 43912313 YNL103W MET4 SGTC_616 4092-0450 108 µM 1.44940944099577 0.116053329014342 no 433 0.0736116368465549 474 787165 SGTC_2572 astragaloside iv 100 µM 1.44701635502805 0.116444242312521 no 434 0.0739461714898425 451 45006101 An anti-inflammatory agent. SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.44237903022918 0.117204411219943 no 435 0.0745977381155028 442 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_774 k060-0086 136 µM 1.44063238193841 0.117491638228187 no 436 0.074844283531897 523 5911235 SGTC_1690 st023502 41.2 µM 1.43840818776817 0.117858116017571 no 437 0.0751591354165769 431 24207482 SGTC_2304 7443016 91.4 µM 1.4359453035595 0.11826486531257 no 438 0.0755089529276762 405 939854 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 1.4329546518307 0.118760109324546 no 439 0.0759353986534131 524 5024745 SGTC_2984 9022109 38.96 µM 1.43076938945183 0.11912290813195 no 440 0.0762481593763935 379 6459207 SGTC_284 0988-0104 32.6 µM 1.42648886183298 0.119835830129798 no 441 0.0768636398548936 488 4666532 SGTC_417 st075190 100 µM 1.42562951187804 0.119979316725113 no 442 0.0769876564432197 478 222757 SGTC_3121 9125696 49.47 µM 1.42357820724624 0.120322314719366 no 443 0.077284304026041 393 1235365 SGTC_557 1315-0110 16.2 µM 1.42264278588597 0.120478955326646 no 444 0.0774198670755235 466 6833801 SGTC_979 1426-2828 121 µM 1.42255082403867 0.120494362510394 no 445 0.0774332041060983 513 747872 SGTC_101 0490-5701 117.494 µM 1.42175389390747 0.120627937396052 no 446 0.077548854273713 404 4661669 SGTC_3255 9139072 49.47 µM 1.42076623236771 0.120793625735313 no 447 0.0776923652457804 457 17646060 SGTC_350 k064-0020 19.8 µM 1.4200111510015 0.120920404835483 no 448 0.0778022173535649 509 2790705 SGTC_3145 9085516 49.47 µM 1.41619536617827 0.121562511959803 no 449 0.0783591561187649 460 25236195 SGTC_907 3448-6986 75.5 µM 1.41604693243187 0.121587538214374 no 450 0.0783808819214819 515 590582 SGTC_273 hydroxyurea 18.1 mM 1.4157763800089 0.121633163260142 no 451 0.0784204936179696 539 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_54 0159-0055 9 µM 1.41502767604914 0.121759484878938 no 452 0.0785301908020668 477 3319099 SGTC_292 k038-0015 474 µM 1.41342195217403 0.122030713989452 no 453 0.0787658473897205 441 46368540 SGTC_231 b-estradiol 524 µM 1.41262169950144 0.122166046113952 no 454 0.0788834926316507 401 450 A steroid. SGTC_3294 9122953 26.2835 µM 1.41183189919811 0.122299713905275 no 455 0.0789997317412425 470 16459826 SGTC_325 2810-4341 181 µM 1.41129936341405 0.122389899528412 no 456 0.0790781810610089 448 774970 SGTC_1723 st034307 2.5525 µM 1.41013777153846 0.122586778525215 no 457 0.0792495030451284 464 867466 SGTC_46 0329-0187a 2.197 µM 1.40847790608966 0.122868495680516 no 458 0.0794948023483765 584 46494817 SGTC_2924 9010168 62.78 µM 1.40832444636481 0.122894564215584 no 459 0.0795175100168336 493 2993929 SGTC_1657 st012939 43.4 µM 1.40663719798993 0.123181436483689 no 460 0.0797674984754371 432 24207257 SGTC_1653 st012112 65 µM 1.40611921131497 0.123269600591441 no 461 0.0798443642849851 447 720429 SGTC_2987 9018338 71.43 µM 1.40343476035821 0.123727216853022 no 462 0.0802436167933452 488 5055682 SGTC_3000 9075062 71.4286 µM 1.4014338291375 0.124069086820942 no 463 0.0805421910339267 458 17057871 SGTC_2198 6589944 200 µM 1.40115409647378 0.124116933274965 no 464 0.0805839988562721 367 5290268 SGTC_1321 1326-2144 215 µM 1.40107480079051 0.124130498634307 no 465 0.0805958530808635 443 3513030 SGTC_2312 7706453 155.7 µM 1.40053510954408 0.124222852850327 no 466 0.0806765686455343 479 976098 SGTC_2165 5727197 32.143 µM 1.3957947419473 0.125036109721684 no 467 0.0813881571098731 482 1361712 SGTC_3201 9113999 49.47 µM 1.39471013860176 0.125222705736216 no 468 0.0815516331516519 480 16649224 SGTC_2805 7950783 58.44 µM 1.39263106378863 0.125580934786436 no 469 0.0818656922051087 550 1178958 YDL195W SEC31 SGTC_311 1315-0136 58 µM 1.39054291053 0.12594144723524 no 470 0.0821820392364841 491 6759207 SGTC_680 0417-1641 114 µM 1.38831897172102 0.126326195530948 no 471 0.0825199688499195 439 2835990 SGTC_1116 jasmonic acid  1.58368 µM 1.3873229688894 0.126498772387892 no 472 0.0826716511318608 491 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1113 artemisinin 1.17947 µM 1.38582691429049 0.126758301442284 no 473 0.0828998809676626 506 2240 An anti-malaria and mitochondrial poison. SGTC_2411 st077133 39.94 µM 1.3830405505533 0.127242655489572 no 474 0.0833262162516613 567 1403142 YNL221C POP1 SGTC_1998 st075797 76.8 µM 1.38099963058668 0.12759824486895 no 475 0.0836395371214619 533 24208315 SGTC_1357 1503-1303 39.5 µM 1.37883591513448 0.127975982737884 no 476 0.0839726752661852 548 292895 SGTC_1596 piperlongumine 63 µM 1.3787754075619 0.127986557204973 no 477 0.0839820056622511 534 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_2872 9044037 25.97 µM 1.37697341529418 0.128301756512805 no 478 0.0842602336253334 408 6465195 SGTC_3306 9127676 59.7925 µM 1.37685276892819 0.12832287886283 no 479 0.0842788861276025 465 41905287 SGTC_1029 k015-0030 64.7 µM 1.37549708691917 0.128560392998014 no 480 0.0844886941122262 485 2208316 SGTC_2733 amorolfine 100 µM 1.37337671805379 0.128932490977715 no 481 0.0848176318807742 362 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3103 9120822 49.47 µM 1.37314855606289 0.128972574994142 no 482 0.0848530843249113 521 17141819 SGTC_355 1311-2252 105 µM 1.37277175227611 0.129038791658485 no 483 0.0849116574673907 510 5338538 SGTC_807 1315-0151 48 µM 1.37052849578102 0.129433492605655 no 484 0.085260993220071 574 4011080 SGTC_15 0266-0086 27.098 µM 1.36712867341755 0.130033284631571 no 485 0.0857924885992246 607 1712902 YIL048W NEO1 SGTC_1332 1480-0653 17.5 µM 1.36484456529435 0.130437322645193 no 486 0.0861509542500893 511 5749438 SGTC_2079 5212404 121 µM 1.36065509395187 0.131180657153346 no 487 0.0868113560108452 478 758462 SGTC_3295 9122362 53.5725 µM 1.36035033422034 0.131234844358917 no 488 0.0868595435928569 471 4730473 SGTC_677 0929-0063 136 µM 1.35707970307622 0.131817345717572 no 489 0.0873779434392173 424 1539583 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.35603809585701 0.13200323050993 no 490 0.0875435236414777 434 6857784 SGTC_1133 3473-0247 50 µM 1.35406930059283 0.132355074492891 no 491 0.0878571346629756 538 711311 SGTC_2197 6588183 93.1375 µM 1.34736495929146 0.133558054772021 no 492 0.0889313601237226 452 884136 SGTC_2242 6630449 61.2675 µM 1.34700959110059 0.133622028735042 no 493 0.0889885718626432 441 691249 YDR170C SEC7 SGTC_2990 9074105 71.4286 µM 1.34191179739565 0.134542061292427 no 494 0.0898122980520621 467 6502001 SGTC_5 0352-0601 109.883 µM 1.34189693579001 0.134544749806217 no 495 0.0898147077198413 451 762456 SGTC_1730 st033808 45.1 µM 1.34184243125473 0.134554610173196 no 496 0.089823545522321 592 1045166 SGTC_2680 butyl paraben 22.24 µM 1.33548001449106 0.13570903896699 no 497 0.0908596460435184 467 7184 An antifungal and steroid mimetic. SGTC_750 4073-0104 132 µM 1.33456026462672 0.135876482574165 no 498 0.0910101551897055 412 22330957 SGTC_3227 9130768 49.47 µM 1.32694283656608 0.137268698857697 no 499 0.0922637963858212 487 17720899 SGTC_3192 9110362 49.47 µM 1.32065029217981 0.138426093860363 no 500 0.0933089977272775 539 16649480 SGTC_2885 9057732 51.95 µM 1.31319543921436 0.139805857919484 no 501 0.0945585502121271 519 6471414 SGTC_2714 st079313 56.9 µM 1.31043412683226 0.1403192936666 no 502 0.0950245075264615 507 2939799 SGTC_465 cgp-37157 41 µM 1.30933613429328 0.140523808715227 no 503 0.0952102573627181 390 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_35 0133-0054 64.071 µM 1.30900569635921 0.140585396567459 no 504 0.0952662105877756 515 99677 SGTC_1229 0139-0193 12.2 µM 1.30291783782196 0.141723345478882 no 505 0.096301406681937 575 3090752 SGTC_1054 3429-0080 167 µM 1.30257843947749 0.14178696925796 no 506 0.0963593612612665 574 1162877 SGTC_277 nystatin 15.5 µM 1.29881139208437 0.142494440639634 no 507 0.0970043320536338 571 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2882 9058044 58.44 µM 1.29763998588577 0.142714922725049 no 508 0.0972055375430978 523 18076804 SGTC_502 l-744,832 89.3 µM 1.29523210481005 0.143168858102485 no 509 0.097620086400971 556 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_921 1561-0023 372 µM 1.29465825032771 0.143277185297289 no 510 0.0977190741226229 555 24050882 SGTC_3167 9103034 49.47 µM 1.29289087907265 0.143611161776218 no 511 0.0980244012642689 466 5127859 SGTC_2213 7173844 200 µM 1.29249803986601 0.143685467101852 no 512 0.098092362152937 566 892728 SGTC_2604 4'-hydroxychalcone 11.32 µM 1.29073632397263 0.14401901374714 no 513 0.0983975622548733 521 5282362 SGTC_2793 7325131 81.82 µM 1.28772540835487 0.144590280066775 no 514 0.0989207828207285 504 4176441 SGTC_383 2324-0395 7.37 µM 1.28641450278234 0.144839476848959 no 515 0.0991492198142178 565 3146421 SGTC_838 0109-0203 71.4 µM 1.28602875513842 0.144912860640165 no 516 0.099216513190758 567 759422 SGTC_2303 7774051 200 µM 1.28586996715549 0.144943075391688 no 517 0.0992442233320967 525 2953184 SGTC_1356 1502-0781 85.8 µM 1.28511346736103 0.145087083141491 no 518 0.0993763180554383 552 567702 SGTC_841 0251-0215 91.2 µM 1.28500100749828 0.145108499286695 no 519 0.0993959659816775 616 3888614 SGTC_622 1348-1566 26.3 µM 1.28406741849135 0.145286368214102 no 520 0.0995591834909854 620 7340407 SGTC_72 0744-0168 198.391 µM 1.28302883676433 0.145484412818452 no 521 0.0997409867186171 542 677577 SGTC_2540 epiandrosterone 100 µM 1.27867746116016 0.146316139158165 no 522 0.100505329902984 712 441302 A steroid. SGTC_1034 k072-0165 12.7 µM 1.27750009704291 0.146541729471825 no 523 0.100712873092367 588 5835461 SGTC_2991 9074669 71.4286 µM 1.27543714233641 0.146937567085635 no 524 0.101077279615971 640 17333109 SGTC_2950 9072895 21.46 µM 1.27508181784427 0.147005818709821 no 525 0.101140142099134 586 17332245 SGTC_1704 st028805 70.8 µM 1.27243923520736 0.147514079578806 no 526 0.10160855056143 552 2876101 SGTC_1193 1488-0126 41.5 µM 1.26982795154036 0.148017475698623 no 527 0.102072960913795 564 1384710 SGTC_2406 ethylparaben 405.7 µM 1.26965922913024 0.148050041041415 no 528 0.10210302080893 491 8434 A possible steroid mimic. SGTC_2798 7813637 45.45 µM 1.26683167493474 0.148596504667342 no 529 0.102607741798795 564 956368 SGTC_967 1306-0166 352 µM 1.26584514761674 0.148787481527829 no 530 0.102784263888425 571 4437607 SGTC_1928 4'-methoxychalcone 40.3 µM 1.26241654538935 0.149452482626042 no 531 0.103399469355241 585 641818 SGTC_323 4013-0906 34.3 µM 1.26105760729917 0.149716606210155 no 532 0.103644046344813 553 2910086 SGTC_2457 5731572 11.68 µM 1.25922479347616 0.150073325354091 no 533 0.103974574319672 566 2865357 SGTC_723 4182-0001 115 µM 1.25659183370147 0.15058676720982 no 534 0.104450736663392 547 744821 YLR208W SEC13 SGTC_1092 toremifene 6.32 µM 1.24809046913311 0.152252559870819 no 535 0.105998964099037 636 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1929 genistein trimethyl ether 50.5 µM 1.24801635526076 0.152267135635468 no 536 0.106012533882722 583 136420 SGTC_2917 7979103 53.79 µM 1.24564394687939 0.152734199885951 no 537 0.106447570322361 656 2980565 SGTC_1744 st037937 38.9 µM 1.24247718818964 0.153359129912494 no 538 0.107030275987439 581 1016152 SGTC_745 0469-0705 296 µM 1.23872649093734 0.154101482990304 no 539 0.107723402372405 664 3486736 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 1.23780788594815 0.154283658777838 no 540 0.107893651849517 587 1609 A potent and irreversible inhibitor of serine proteases. SGTC_2900 5328528 85.29 µM 1.23565048123931 0.154712070490235 no 541 0.108294255801079 634 795359 SGTC_1255 0566-0045 221 µM 1.23534503028912 0.154772789591946 no 542 0.108351060742936 604 2788469 SGTC_120 rhodamine 6G 52.259 µM 1.23515119484447 0.154811329357089 no 543 0.108387119584553 699 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2712 st079126 47.7 µM 1.23384381964881 0.155071436721839 no 544 0.108630553666491 544 3152970 SGTC_2484 5809818 12.04 µM 1.2309364536003 0.155650902258408 no 545 0.109173316111153 583 2870548 SGTC_2053 5265679 138 µM 1.23052196268649 0.155733630379796 no 546 0.109250853893528 619 764595 SGTC_2140 5586273 200 µM 1.23012377391901 0.155813132062615 no 547 0.10932537932827 554 854421 SGTC_667 1498-1044 59 µM 1.22917928423268 0.156001814239623 no 548 0.109502297056369 619 6739982 SGTC_2224 6650123 117.647 µM 1.22634872576633 0.156568180884261 no 549 0.11003373621454 549 2908370 SGTC_71 0417-1750 47.813 µM 1.22503152636665 0.156832200383924 no 550 0.110281671174931 634 6811472 SGTC_2704 st078022 71.1 µM 1.2249696631342 0.156844607451159 no 551 0.110293325463835 599 54697681 SGTC_708 3448-5400 146 µM 1.22464056394826 0.156910621255848 no 552 0.110355338639198 640 3462195 SGTC_328 k915-0120 63.5 µM 1.2229588971522 0.157248231091432 no 553 0.110672610609413 599 6624543 SGTC_3169 9102970 49.47 µM 1.22260869320206 0.157318597746805 no 554 0.11073876406077 588 17027839 SGTC_1960 st011366 51.8 µM 1.22247451298807 0.157345564128747 no 555 0.1107641181812 590 3972846 SGTC_33 0986-0033 35.816 µM 1.22015670968157 0.157811855795086 no 556 0.111202737039246 562 2848082 SGTC_41 0478-0632 82.643 µM 1.21712105725291 0.158423934408541 no 557 0.111779080020788 693 3750424 SGTC_2543 pimpinellin 60.67 µM 1.21396662354121 0.159061610556701 no 558 0.112380234849911 580 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_3285 9112818 20.8695 µM 1.21310159682955 0.159236771120239 no 559 0.112545489786249 652 17017947 YPR165W RHO1 SGTC_1888 azatryptophan 97.5 µM 1.20883770724765 0.160102017898451 no 560 0.113362600943627 563 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2023 5144124 124 µM 1.20767114476609 0.160339276309368 no 561 0.113586890699107 607 2830192 SGTC_81 0411-0046 9.971 µM 1.20620177111044 0.160638448029575 no 562 0.113869850603074 562 12925265 SGTC_703 3875-0075 71.8 µM 1.20379204282 0.161129869303379 no 563 0.114334982995909 662 2850814 SGTC_2430 5571206 200 µM 1.20361194429603 0.161166636552048 no 564 0.1143698003617 686 1731771 SGTC_2769 toremifene 3.73 µM 1.20307046693914 0.161277212526349 no 565 0.114474526390826 585 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2171 5739187 198.077 µM 1.19952511157811 0.162002437799979 no 566 0.115161913208026 541 2262761 SGTC_1492 4158-0558 28.5 µM 1.19507300618543 0.16291614851378 no 567 0.116029253758865 601 3967268 SGTC_1214 0358-0031 63.7 µM 1.19502257691735 0.162926517325227 no 568 0.11603910466631 615 4301366 SGTC_2730 imipramine 71.33 µM 1.19170113932453 0.163610386090374 no 569 0.116689225587123 727 3696 A tricyclic antidepressant. SGTC_2138 5575593 77.673 µM 1.19093100560627 0.163769218881332 no 570 0.116840335677234 583 762213 SGTC_2010 4012422 159 µM 1.18900361822294 0.164167162807089 no 571 0.117219121565531 651 952393 SGTC_2826 7992541 19.48 µM 1.18835806677909 0.164300588645208 no 572 0.117346184854994 604 2985066 SGTC_2628 lathosterol 100 µM 1.18779719525486 0.164416569475764 no 573 0.117456659839498 633 6710616 SGTC_2388 9080168 200 µM 1.18668436784484 0.164646844576879 no 574 0.117676071660054 590 15943073 SGTC_2045 5106652 78.05 µM 1.18466880485994 0.165064452647333 no 575 0.11807421053805 615 673349 SGTC_3238 9133470 49.47 µM 1.17953219272763 0.166131814173151 no 576 0.119093162746745 627 3534688 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 1.17800427988922 0.166450165082432 no 577 0.119397449995469 615 688803 SGTC_449 xestospongin c 11.1929 µM 1.17215281408933 0.167672996957844 no 578 0.120567854486884 667 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_2244 6635614 200 µM 1.16988551509609 0.168148365502637 no 579 0.121023521876942 505 836499 SGTC_1504 k297-0033 30 µM 1.16936753455422 0.168257088381581 no 580 0.121127792122594 524 4388117 SGTC_1131 3454-3128 32.3 µM 1.16846092264251 0.168447492873151 no 581 0.121310446500127 682 710982 SGTC_1025 k007-0731 70 µM 1.16510061762362 0.169154424081433 no 582 0.121989133454688 620 6256118 SGTC_654 1124-0271 80.9 µM 1.16479508191055 0.169218796143082 no 583 0.122050975061914 670 5403748 SGTC_1353 1498-1206 8.11 µM 1.16460879568042 0.169258051738843 no 584 0.122088690915544 717 6756808 SGTC_903 1134-0042 114 µM 1.16347839464839 0.169496383461191 no 585 0.122317729500889 631 701009 SGTC_2849 9019321 12.99 µM 1.16237444160662 0.169729346670439 no 586 0.122541700202967 613 16489627 SGTC_806 3966-4455 5.86 µM 1.16079428501735 0.170063158548279 no 587 0.122862783831694 576 714982 SGTC_223 busulfan 5 mM 1.15856267426375 0.170535307912782 no 588 0.123317245405985 554 2478 A DNA alkylator. SGTC_3 0833-0587 95.581 µM 1.15458397384923 0.171379174920852 no 589 0.124130416291294 644 5382644 SGTC_933 2914-0560 114 µM 1.15444845561082 0.171407964743383 no 590 0.124158179559351 718 463887 SGTC_2013 4024628 200 µM 1.15327656119203 0.171657053765177 no 591 0.124398443728148 590 5230760 SGTC_744 1594-0068 283 µM 1.15170988028582 0.171990416645829 no 592 0.124720155419664 728 668392 SGTC_3020 9089140 49.47 µM 1.14703822896319 0.17298691582041 no 593 0.125682910731911 642 17217859 SGTC_98 0074-0023 107.663 µM 1.14631360290483 0.173141813021629 no 594 0.125832708232478 700 3563821 SGTC_2043 5101342 149 µM 1.1411487129043 0.174248425563149 no 595 0.126904021376832 664 678451 SGTC_894 0960-0238 55.9 µM 1.13678179435235 0.175187565820924 no 596 0.127814757938917 678 6741907 YDL195W SEC31 SGTC_3317 9138495 8.753 µM 1.13592818881688 0.175371514820425 no 597 0.127993309841013 684 17020139 SGTC_1904 st060225 78 µM 1.1340121537525 0.175784859389835 no 598 0.128394724969602 670 66595 SGTC_2386 9075165 157.42 µM 1.13363302696045 0.17586672116007 no 599 0.128474256641271 657 16452277 SGTC_1559 coumarin 343 70.1 µM 1.13150905263492 0.176325780114283 no 600 0.128920447696097 634 108770 A hepatotoxic, DNA x-linker. SGTC_1811 st050069 61.5 µM 1.13107877143029 0.176418869953817 no 601 0.12901096920324 647 3877702 SGTC_1691 st019933 84.6 µM 1.13035329825658 0.176575893934895 no 602 0.129163692259675 650 6176082 SGTC_306 1672-3436 11.6 µM 1.13003306420443 0.176645234636336 no 603 0.12923114622 684 6797378 SGTC_1235 benzylparaben 21.5 µM 1.12687098999083 0.177330846889642 no 604 0.129898515195703 656 7180 SGTC_725 1497-0963 19 µM 1.12628602700197 0.177457864587271 no 605 0.130022235137956 706 3549977 SGTC_2072 5231554 129 µM 1.12443491693755 0.177860189248487 no 606 0.130414283098974 699 789545 SGTC_3053 9095903 49.47 µM 1.12246524489432 0.178288913682892 no 607 0.130832338431979 679 17174018 SGTC_1485 3909-9022 254 µM 1.12224018510175 0.178337942262351 no 608 0.130880165405051 704 714516 SGTC_1852 st056254 31.4 µM 1.12159147168007 0.178479310003181 no 609 0.131018089701538 669 442583 SGTC_515 4092-1064 102 µM 1.1190077144447 0.179043063030917 no 610 0.131568423973034 758 717353 SGTC_2964 9083345 53.42 µM 1.11352401533743 0.1802432651982 no 611 0.132741720025927 633 17741579 SGTC_2107 5363541 170.161 µM 1.11267194027004 0.180430208750538 no 612 0.132924675452063 713 244052 SGTC_51 1013-0126 23.419 µM 1.11188700387413 0.180602529812404 no 613 0.133093368596488 658 1627850 SGTC_1167 k781-0610 148 µM 1.10955208143759 0.181115737033923 no 614 0.13359604494489 745 4525169 SGTC_1689 st020265 53.493 µM 1.10851949107306 0.18134298759244 no 615 0.133818763108214 711 5758320 YPR016C TIF6 SGTC_2122 5258151 111.688 µM 1.10827494502719 0.181396832966501 no 616 0.133871546304545 701 2173356 SGTC_1518 st038567 90.8 µM 1.10769570247001 0.181524413425405 no 617 0.133996627994729 676 77966 SGTC_2960 9079389 5.97 µM 1.10765977145115 0.181532329223637 no 618 0.134004389586512 726 16457355 SGTC_3310 9130229 44.1445 µM 1.10657186032481 0.181772104237839 no 619 0.134239539561438 681 7761258 SGTC_2857 9024691 58.44 µM 1.10647220564147 0.181794077976413 no 620 0.134261093897497 649 16478292 SGTC_2591 skatole 100 µM 1.10536917227944 0.182037406487804 no 621 0.134499828016145 683 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2942 9052777 62.25 µM 1.10218599134093 0.18274075539358 no 622 0.135190410454343 766 6469503 SGTC_3037 9091026 49.47 µM 1.1019567013699 0.182791484240549 no 623 0.135240247983244 799 25236398 YIL048W NEO1 SGTC_594 1487-1584 10.8 µM 1.1015130350707 0.18288966735083 no 624 0.135336717233763 696 5013332 SGTC_1389 3405-0187 19 µM 1.10085568626811 0.183035198779225 no 625 0.13547973555636 640 799890 SGTC_1351 1496-0003 46.5 µM 1.0983967341566 0.183580230230358 no 626 0.136015643921367 739 3891978 SGTC_2314 7727897 200 µM 1.09820087360719 0.183623686543064 no 627 0.136058392427871 681 900724 SGTC_1822 st052468 42 µM 1.09314113020894 0.184748531635826 no 628 0.137165919845172 672 2873678 SGTC_1922 5578187 25 µM 1.09205147572667 0.184991335056776 no 629 0.137405238051106 680 1350412 SGTC_2661 dactinomycin 12.96 µM 1.09071497151501 0.185289413619674 no 630 0.137699160366026 751 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2461 5755302 26.15 µM 1.08674030110627 0.186177639416563 no 631 0.138575798915691 745 2788904 SGTC_2265 7929201 200 µM 1.08552897723546 0.186448859647893 no 632 0.138843718371998 707 1265108 SGTC_3312 9133330 71.43 µM 1.08480401499266 0.186611298578321 no 633 0.139004233450169 770 17617324 SGTC_1786 berberine 21.6 µM 1.08230572265568 0.187171750361733 no 634 0.139558351997077 704 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_144 4161-2749 112.381 µM 1.08043812613752 0.187591394854567 no 635 0.13997356285008 642 797501 YMR168C CEP3 SGTC_2782 7736369 71.43 µM 1.07962507900587 0.187774266095881 no 636 0.140154584460819 745 2950836 YOL077C BRX1 SGTC_1375 2910-0797 186 µM 1.07733652324063 0.188289600841839 no 637 0.140664975568993 722 742508 SGTC_258 haloperidol 50.781 µM 1.07636515700722 0.188508595658294 no 638 0.140881989418841 704 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1907 st060210 83.7 µM 1.07568900074358 0.188661127975547 no 639 0.141033184138634 798 688793 SGTC_1098 clofazimine 15.1 µM 1.07517459819541 0.188777221640644 no 640 0.141148282930289 768 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_3349 9149703 23.001 µM 1.07513949245655 0.188785146133421 no 641 0.141156140243741 700 4910494 SGTC_3134 9127454 49.47 µM 1.07499982486462 0.188816675624993 no 642 0.141187403370287 742 24262820 SGTC_2699 st077704 54.6 µM 1.06936266454722 0.190091953110856 no 643 0.142453141942028 720 645852 SGTC_2916 7875993 68.79 µM 1.06741718043791 0.190533299789955 no 644 0.142891746882597 736 1299250 SGTC_3047 9092122 49.47 µM 1.06667292348093 0.190702305925935 no 645 0.143059779018464 700 17173831 SGTC_2722 naftopidil 47.16 µM 1.06655768753405 0.190728481969154 no 646 0.143085807961184 760 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_3018 9082602 49.47 µM 1.06609545566902 0.190833500890277 no 647 0.14319024683147 762 17332089 SGTC_2258 7960471 200 µM 1.06569397197976 0.190924746632229 no 648 0.143281001744093 630 2974708 SGTC_2173 5763948 167 µM 1.06536095667344 0.19100045177465 no 649 0.143356308927895 760 2867177 SGTC_2719 novobiocin 32.65 µM 1.06481186470928 0.191125318324701 no 650 0.14348053746084 687 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_1039 k821-0043 94 µM 1.06384479201095 0.191345357680392 no 651 0.143699508120913 761 15992768 SGTC_1484 3473-2379 286 µM 1.06381618907317 0.191351868108457 no 652 0.143705988009018 864 671917 SGTC_1213 1315-0166 115 µM 1.06348463288454 0.191427344834233 no 653 0.143781115207925 629 768401 SGTC_1964 st076914 61 µM 1.06152776983775 0.191873184129383 no 654 0.144225059797836 761 24208661 SGTC_1172 0370-0043 85 µM 1.06076704305655 0.192046674754673 no 655 0.144397891591076 730 376585 SGTC_3335 9143315 29.6265 µM 1.0601583669611 0.192185557953262 no 656 0.144536279013085 719 4899691 SGTC_1069 diphenylcyclopropenone 8.49 µM 1.05218110941435 0.194011423992178 no 657 0.14635823237564 838 65057 A dermal irritant. YDR527W RBA50 SGTC_2982 9019404 25.97 µM 1.04970335569101 0.194580686306924 no 658 0.146927260225065 616 22333232 SGTC_1206 3978-0017 132 µM 1.04711324267851 0.195176848480151 no 659 0.147523676160273 704 3873677 SGTC_321 4534-3890 65.3 µM 1.04533279381379 0.19558729461723 no 660 0.14793459304209 757 699746 SGTC_3154 9100113 49.47 µM 1.04378444623917 0.195944660262058 no 661 0.148292564651851 735 25237525 SGTC_50 0929-0078 56.389 µM 1.04243675700881 0.196256035297518 no 662 0.148604616181551 716 1377751 SGTC_1412 3909-8563 178 µM 1.042086739174 0.196336953743188 no 663 0.148685733039137 844 23767530 SGTC_99 0109-0120 622.8 µM 1.04205051049698 0.196345330380485 no 664 0.148694130748263 718 759414 SGTC_2806 7952793 58.44 µM 1.04144663253512 0.196484988317613 no 665 0.14883415470851 770 2972490 SGTC_3067 9117431 49.47 µM 1.04043098566262 0.196720011141419 no 666 0.149069856089617 708 17150885 SGTC_2408 sulbentine 18.36 µM 1.0383657961234 0.197198425145119 no 667 0.14954989360664 747 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_341 1486-1430 230 µM 1.03814873435529 0.197248749703104 no 668 0.149600407799887 730 2054753 YPL210C SRP72 SGTC_2929 9013348 24.6 µM 1.035939670291 0.197761350617966 no 669 0.150115144417558 719 2995952 SGTC_2280 7785178 200 µM 1.03363104828293 0.198297912690998 no 670 0.150654339373493 745 2954328 SGTC_818 4072-2707 53.5 µM 1.03191745630979 0.198696747450249 no 671 0.151055393806926 747 882871 SGTC_3079 9117512 49.47 µM 1.0311618175934 0.19887277426903 no 672 0.151232471367264 842 7185044 SGTC_2390 9097792 176.6 µM 1.02728365445495 0.199777674591966 no 673 0.152143458421242 738 4497149 SGTC_458 nppb 133 µM 1.02639799883338 0.199984673434009 no 674 0.152352010463451 753 4549 A chloride channel blocker. SGTC_3070 9117005 49.47 µM 1.02499870338148 0.200311984865305 no 675 0.152681899735067 726 8779016 SGTC_3029 9088683 49.47 µM 1.02343582857201 0.200677939649729 no 676 0.153050913223994 753 25236615 SGTC_2011 4012611 177 µM 1.02284777094877 0.200815740074278 no 677 0.15318991362778 781 2049887 SGTC_2146 5545642 200 µM 1.02150053850007 0.201131653075947 no 678 0.153508677047964 783 825326 SGTC_3179 9107801 49.47 µM 1.02053198716079 0.201358953059139 no 679 0.153738113445111 770 4818259 SGTC_1108 betulinic acid 729.144 nM 1.01949058021574 0.201603522521335 no 680 0.153985061465042 793 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_760 0568-0725 82.9 µM 1.0181975830214 0.201907424263836 no 681 0.154292033928198 840 3916171 SGTC_1256 0570-0116 285 µM 1.01548409778842 0.202546083787121 no 682 0.154937561537472 736 410638 SGTC_450 aminopyrene 156 nM 1.01427832471492 0.202830267707768 no 683 0.15522498187274 799 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_2379 9035213 200 µM 1.01372041515063 0.202961839787557 no 684 0.155358089893419 851 646551 SGTC_668 1682-0499 62.6 µM 1.0129371754958 0.203146637555428 no 685 0.15554508502188 827 682214 SGTC_2320 7373003 200 µM 1.01278396032612 0.203182798925211 no 686 0.155581681846331 760 5415828 SGTC_1782 st039423 80.636 µM 1.0119648098971 0.203376197449638 no 687 0.155777439661964 731 2068169 SGTC_520 3584-0023 682 µM 1.00874821851953 0.204136685092821 no 688 0.156547700210493 728 1340790 SGTC_2892 9047358 58.44 µM 1.00820884756146 0.204264372334283 no 689 0.15667710566834 723 6466771 SGTC_787 4152-0075 138 µM 1.00628578549362 0.204720012686349 no 690 0.157139058094613 759 9566539 SGTC_1628 st004252 77.7 µM 1.00533983671142 0.204944362541717 no 691 0.157366619516415 796 692968 SGTC_149 3970-0822 46.1 µM 1.00188307684691 0.205765441440917 no 692 0.158200033473714 912 3114250 YBL034C STU1 SGTC_3092 9117248 49.47 µM 1.00038087111628 0.206122865686391 no 693 0.158563111821979 863 17141857 SGTC_646 4092-0839 27.3 µM 0.996707908246414 0.206998333509094 no 694 0.159453154979286 836 877796 SGTC_2001 4023502 57.655 µM 0.994137518875696 0.207612304350062 no 695 0.160077960820536 798 108941 YCR052W RSC6 SGTC_2419 paclitaxel 166.5 µM 0.991833254849479 0.208163621315004 no 696 0.160639436289263 828 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1632 st005650 90 µM 0.985250640017313 0.209743325965918 no 697 0.162250485889252 783 2759605 SGTC_2059 5238311 157 µM 0.982706998852661 0.210355635440618 no 698 0.162875832555872 784 703021 SGTC_1871 st057448 67.3 µM 0.981105296195858 0.21074173783679 no 699 0.163270409484684 855 691747 SGTC_2359 9039622 200 µM 0.980128245372193 0.210977467234719 no 700 0.163511409141747 862 6463596 SGTC_2102 5377816 72.7585 µM 0.979912320561738 0.211029583454758 no 701 0.163564700374905 856 1379702 SGTC_1655 st012546 55.1 µM 0.979427877461547 0.211146537460089 no 702 0.163684304185135 795 720985 YLR208W SEC13 SGTC_3066 9117245 49.47 µM 0.9790746421249 0.21123183929507 no 703 0.163771549988638 852 17176980 SGTC_3222 9128301 49.47 µM 0.977561831715197 0.211597392079292 no 704 0.164145541303467 839 4911358 SGTC_930 2810-3379 265 µM 0.97638229715323 0.211882669459431 no 705 0.164437525435211 895 1015764 SGTC_525 k781-2675 26.7 µM 0.974603902880757 0.212313209675455 no 706 0.164878388452307 836 3651118 YDL195W SEC31 SGTC_2480 5767542 37.17 µM 0.973193962960686 0.212654912033912 no 707 0.165228455348899 853 2867358 SGTC_2266 7929956 200 µM 0.972629013607736 0.21279191894744 no 708 0.165368858673443 827 2967153 SGTC_563 tetrahydrosecaminediol 614 µM 0.968554323944671 0.213781604450319 no 709 0.166383801132645 868 334274 A psychoactive constituent of the cannabis plant. SGTC_2267 7931562 200 µM 0.968210614023489 0.213865209236775 no 710 0.166469597546806 749 934880 SGTC_1646 st011709 75.6 µM 0.968163584104825 0.213876650382154 no 711 0.166481339313686 800 5757843 SGTC_1252 0493-0875 34.8 µM 0.968067140769208 0.213900113630239 no 712 0.166505419598049 799 3960963 SGTC_2867 9039098 71.43 µM 0.967360936735161 0.214071968366528 no 713 0.166681815415181 790 6463460 SGTC_152 4469-0003 551.229 µM 0.966913907672592 0.214180794399283 no 714 0.16679353674889 837 697280 SGTC_93 0109-0045 59.227 µM 0.964445304481514 0.214782337622999 no 715 0.167411358914939 985 88733 SGTC_397 arbidol 50 µM 0.962776256506585 0.215189602772111 no 716 0.167829909292144 897 131410 A RNA synthesis inhibitor. SGTC_1975 st070967 30.8 µM 0.959751884803789 0.215928721974854 no 717 0.168590051687782 921 261391 SGTC_1287 0971-0001 34.6 µM 0.95341787226491 0.217481433888739 no 718 0.170189194810685 895 4665869 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.949999854734334 0.218321992873146 no 719 0.171056163214542 892 4174840 SGTC_3241 9133421 49.47 µM 0.949770097940187 0.218378561722659 no 720 0.171114541387261 865 17018221 SGTC_2868 9035608 32.47 µM 0.947412459087165 0.218959528008815 no 721 0.171714322422866 839 6462614 SGTC_3182 9108849 49.47 µM 0.946892202817436 0.219087848509498 no 722 0.171846855759789 883 17133045 SGTC_1555 citronellol 128 µM 0.945778084766288 0.219362789616716 no 723 0.172130892826033 827 8842 A terpine precursor. SGTC_940 3232-1287 54.8 µM 0.945459270708883 0.219441502749834 no 724 0.1722122274793 866 1585493 YIL048W NEO1 SGTC_1168 k815-0004 80.5 µM 0.943677365852983 0.219881742255133 no 725 0.172667271886959 861 642433 SGTC_3077 9117319 49.47 µM 0.943546585484302 0.219914072960265 no 726 0.172700699390741 816 17154678 SGTC_581 0958-0271 211 µM 0.941796967318384 0.220346864926147 no 727 0.173148299072653 914 4591145 SGTC_2907 7721985 69.9 µM 0.941778072884978 0.220351541385839 no 728 0.173153136809173 853 3267881 SGTC_1993 st073995 70.8 µM 0.940908566826056 0.220566809704709 no 729 0.173375858538644 877 3098394 SGTC_2047 4141938 200 µM 0.93878469926343 0.221093133395376 no 730 0.173920648117162 810 3807862 SGTC_3229 9132204 49.47 µM 0.937054599693761 0.221522406586984 no 731 0.174365236582777 873 17682924 SGTC_2723 salbutamol 83.58 µM 0.936901652570609 0.221560378812508 no 732 0.174404574533635 807 9884233 β2-adrenoceptor agonist SGTC_1574 spiramycin 23.7 µM 0.935728322599112 0.221851805491128 no 733 0.174706542124456 868 6419898 An antibiotic and protein synthesis inhibitor. SGTC_585 0kpi-0023 191 µM 0.935386400568249 0.221936771800838 no 734 0.174794601420735 832 64601 SGTC_1318 1280-3875 124 µM 0.934844261564156 0.222071529340169 no 735 0.174934282742902 880 373245 SGTC_2649 anisomycin 9.56 µM 0.934396632874396 0.222182829986706 no 736 0.17504966699104 867 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1688 st021091 57.6 µM 0.933267227820249 0.222463792379466 no 737 0.175341005745624 894 3656366 SGTC_3269 9137823 49.47 µM 0.9327553934454 0.222591188241908 no 738 0.175473138548416 797 17682936 SGTC_3091 9116372 49.47 µM 0.928945734472219 0.223540720423558 no 739 0.176458604873483 826 17169793 SGTC_1328 1441-0025 69.2 µM 0.928024213772576 0.223770748895472 no 740 0.176697504747784 828 4562601 SGTC_2812 7970281 58.44 µM 0.927580778980685 0.223881486289301 no 741 0.17681253595858 880 2233435 SGTC_717 1532-0246 73.2 µM 0.927233879442526 0.223968137984653 no 742 0.176902557996992 852 9561992 SGTC_1124 fisetin 1.16336 µM 0.925526734098 0.224394841669599 no 743 0.177345992043151 835 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2112 5488546 200 µM 0.925402120206176 0.224426007168952 no 744 0.177378388185592 867 600757 SGTC_1524 corynanthine 62.1 µM 0.92425643048833 0.224712655259888 no 745 0.17767641068139 854 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_2062 5245942 200 µM 0.924120795552385 0.224746604449857 no 746 0.177711713618068 966 1376160 SGTC_1369 1866-0067 208 µM 0.918738986833998 0.22609600708036 no 747 0.179116056190211 944 3531355 SGTC_2943 9068529 45.32 µM 0.918203592447143 0.226230498646546 no 748 0.179256144128631 989 3270634 SGTC_2106 5357045 167.29 µM 0.916582569292918 0.226637976647399 no 749 0.179680710872425 902 668842 SGTC_997 3996-0078 137 µM 0.916135357138422 0.226750465617959 no 750 0.179797952581264 903 735687 SGTC_681 1642-0006 26.6 µM 0.915090993977893 0.227013280896881 no 751 0.180071931257304 888 4446530 SGTC_2489 cantharidin 73.42 µM 0.9148561383125 0.227072406262964 no 752 0.180133579473122 874 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_102 gallobenzophenone 83.616 µM 0.914257215496454 0.227223225530168 no 753 0.18029085311685 895 70837 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.913674841235759 0.227369931702948 no 754 0.18044386381089 865 4330530 SGTC_1882 5615643 20 µM 0.911967647012176 0.227800299156314 no 755 0.180892874472036 860 2253075 SGTC_37 0566-0070 1.56 µM 0.911327733068327 0.227961733431368 no 756 0.181061359082509 947 1626686 SGTC_672 1441-0018 53.7 µM 0.911104131250421 0.228018157743717 no 757 0.181120254960224 844 251141 SGTC_3057 9095946 49.47 µM 0.910234108662847 0.228237776421695 no 758 0.181349529812568 912 24540043 SGTC_2455 5377712 9.75 µM 0.909536790153481 0.228413885445164 no 759 0.181533423531458 806 2243908 SGTC_2580 diallyl disulphide 81.36 µM 0.909228156166412 0.228491855874041 no 760 0.18161485235369 844 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_2316 5844804 197.44 µM 0.909226339885224 0.228492314766731 no 761 0.181615331622082 1034 776813 SGTC_588 3970-1144 52.9 µM 0.906719400526562 0.229126199099934 no 762 0.182277600718474 889 1888707 SGTC_1015 4130-4525 82 µM 0.906629227339716 0.229149017921974 no 763 0.182301450246562 901 1363237 SGTC_2533 agelasine 13.65 µM 0.904569687119522 0.22967054279615 no 764 0.182846700183446 931 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2355 9061122 103.12 µM 0.903949363326246 0.229827753805358 no 765 0.183011126148483 907 5302957 SGTC_1349 flufenamic acid 69 µM 0.903620454916353 0.229911134746051 no 766 0.183098345585497 870 3371 A non-steroidal anti-inflammatory. SGTC_756 0508-1999 28.3 µM 0.901947630342446 0.230335471266126 no 767 0.183542343901529 865 6753853 SGTC_3171 9103192 49.47 µM 0.900673733697881 0.230658907366984 no 768 0.183880909101256 938 13018434 SGTC_748 act1.228 77.9 µM 0.900360291515084 0.230738527678037 no 769 0.18396427263256 920 4421505 YNR035C ARC35 SGTC_180 1486-1293 102.781 µM 0.898894526539535 0.231111063712134 no 770 0.184354421846177 929 4140536 SGTC_1114 scopoletin 1.73284 µM 0.898260116710692 0.231272408126049 no 771 0.184523445053246 914 5280460 A coumarin with genotoxic properties. SGTC_475 α-linolenic acid 10 µM 0.895929360591527 0.231865709963124 no 772 0.185145245953926 968 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_220 paclitaxel 373.376 µM 0.893693268641811 0.232435710632181 no 773 0.185743013964639 850 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_641 4092-0595 30 µM 0.893656384125969 0.23244511936789 no 774 0.185752884222287 934 786260 SGTC_856 0433-0016 11.3 µM 0.892947903683308 0.232625884145735 no 775 0.185942535983986 928 3911780 SGTC_2757 clomiphene 4.22 µM 0.891849151927654 0.232906378949396 no 776 0.186236896110308 1003 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_274 sirtinol 40.1 µM 0.891772924915263 0.232925845526338 no 777 0.186257328347249 909 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_324 1315-0088 19.6 µM 0.89088946451643 0.233151526351661 no 778 0.186494236441624 865 6787421 SGTC_3163 9099914 49.47 µM 0.889969387955636 0.233386689794829 no 779 0.186741161791264 903 16268368 SGTC_3332 9141069 11.198 µM 0.88737157842668 0.234051376757547 no 780 0.187439440049351 860 17332883 SGTC_2287 7945887 168.79 µM 0.884331102884171 0.234830656074691 no 781 0.188258751502001 973 1245853 SGTC_2686 alizarin 95.37 µM 0.884010824795849 0.234912827331061 no 782 0.188345184710849 872 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_3258 9138477 49.47 µM 0.883582501421967 0.235022743755241 no 783 0.188460814272945 937 4970355 SGTC_2569 tetrandrine 100 µM 0.882415662173212 0.235322322344485 no 784 0.188776034535427 829 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2417 cerulenin 830 nM 0.881217227602235 0.235630232148214 no 785 0.189100128274543 922 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_2035 5154463 94.595 µM 0.881065098338702 0.235669334102417 no 786 0.189141293224681 924 2769623 SGTC_3051 9093778 49.47 µM 0.878101794616002 0.236431708735114 no 787 0.189944239584329 906 17217378 SGTC_2760 etidronate 98.04 µM 0.874873886307294 0.237263701099507 no 788 0.190821264605992 918 3305 A chelator and antioxidant. SGTC_3130 9127414 49.47 µM 0.874665237895517 0.237317535436765 no 789 0.190878039894415 933 1494646 SGTC_1268 0828-0275 2.46 µM 0.872161271658354 0.237964118299925 no 790 0.191560201983305 990 745337 SGTC_793 0488-0545 106 µM 0.869187237110386 0.238733336935864 no 791 0.192372363548783 932 292548 SGTC_3099 9120367 49.47 µM 0.868940696145157 0.238797164484295 no 792 0.192439784346672 955 24824940 SGTC_187 1488-2104 32.728 µM 0.867645590317664 0.239132610629798 no 793 0.192794190169669 994 2852859 SGTC_23 0213-0011 39.996 µM 0.867010414174332 0.239297222065937 no 794 0.192968151821368 952 627608 SGTC_1997 st073024 93.8 µM 0.865775616590942 0.239617407693468 no 795 0.193306611632156 969 686268 SGTC_1046 2001-0062 216 µM 0.865515421741235 0.239684906585703 no 796 0.193377977602931 905 739778 SGTC_517 1365-0151 113 µM 0.863086252222199 0.240315574129523 no 797 0.194045023031502 918 768657 SGTC_2880 9042983 58.44 µM 0.861348778425245 0.240767215768296 no 798 0.194522988940132 928 6464714 SGTC_2329 6138490 200 µM 0.859220042619431 0.241321191692403 no 799 0.195109563829373 823 720019 SGTC_1867 st057372 64 µM 0.858562724601898 0.241492390035159 no 800 0.195290905367462 980 688837 SGTC_1159 4092-0538 61.2 µM 0.857916212617394 0.241660838272279 no 801 0.195469365584924 1013 717301 SGTC_188 3229-0966 278.469 µM 0.855208959206665 0.242366903499535 no 802 0.196217738611306 1079 5722370 SGTC_1371 2421-0008 32.7 µM 0.852715080373064 0.243018307387602 no 803 0.196908662984903 924 2827552 SGTC_1670 st016595 4.04 µM 0.852549059358725 0.24306170585225 no 804 0.196954711021062 1008 597879 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.852040571890284 0.243194652301152 no 805 0.197095787028996 972 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1297 1068-0111 14.1 µM 0.850762048311812 0.24352910194824 no 806 0.197450773823247 935 767057 SGTC_2243 6634756 200 µM 0.850460550822394 0.243608007018142 no 807 0.197534542015113 925 885676 SGTC_632 0781-2353 4.65 µM 0.849285863851694 0.243915566619021 no 808 0.197861122425967 991 6811515 YHR007C ERG11 SGTC_1604 st002052 72.4 µM 0.848924746647861 0.244010157352921 no 809 0.197961583881367 958 6254834 YHR062C RPP1 SGTC_40 0327-0103 19.753 µM 0.848141318011808 0.24421543599791 no 810 0.198179636691174 933 409036 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.846469214109398 0.244653881889968 no 811 0.198645520497922 933 6708760 SGTC_96 0929-0093 37.281 µM 0.843964200948872 0.245311519064007 no 812 0.199344705251084 930 6991579 SGTC_2933 9026794 32.47 µM 0.843677470126851 0.245386854617695 no 813 0.19942483030097 964 17586027 SGTC_3137 9097352 49.47 µM 0.843271383991948 0.245493570814498 no 814 0.1995383415795 1023 44120435 SGTC_1380 2291-0730 164 µM 0.840325283450424 0.246268528619703 no 815 0.200363014517283 933 2999191 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.840058017050052 0.246338896612307 no 816 0.200437928935872 980 6312947 SGTC_826 1683-5028 118 µM 0.839077449207121 0.246597160482072 no 817 0.200712924866857 958 722377 SGTC_1792 st045773 43.6 µM 0.838889333104698 0.246646723443626 no 818 0.200765707078821 965 2919270 SGTC_2894 9048625 32.47 µM 0.837568182787866 0.246994957260065 no 819 0.201136634275534 1006 4092861 SGTC_613 3914-0030 117 µM 0.836525249561469 0.247270043253843 no 820 0.201429739092737 790 1145395 SGTC_1768 st044301 37.178 µM 0.835524603461908 0.247534129415435 no 821 0.201711200062003 1043 3931349 SGTC_3193 9111931 49.47 µM 0.834815420567854 0.247721385080737 no 822 0.201910821036264 991 17087244 SGTC_58 0957-0393 9 µM 0.833202147207774 0.248147642241257 no 823 0.202365365911814 1043 6997992 SGTC_3049 9092223 49.47 µM 0.83235021543901 0.248372896375997 no 824 0.202605647090022 949 8623917 SGTC_233 rapamycin 362 pM 0.831772208516108 0.248525785732374 no 825 0.20276876680488 1056 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_3122 9126309 49.47 µM 0.830981108583177 0.248735121850514 no 826 0.202992150786594 1065 17591206 SGTC_1854 st056233 32.9 µM 0.830197068705463 0.248942682383585 no 827 0.203213686148739 966 5393174 SGTC_1045 1348-1485 165 µM 0.830106369422564 0.248966699343324 no 828 0.203239323106659 1105 6810614 SGTC_739 1486-1183 203 µM 0.830030926438354 0.248986677409893 no 829 0.203260649206805 1031 4346692 SGTC_1779 st039427 55 µM 0.829799984887334 0.249047838374548 no 830 0.203325939690067 1078 1124498 SGTC_1062 mesoridazine 14.2 µM 0.828979411132842 0.249265218098905 no 831 0.203558028852493 993 4078 A neuroleptic. SGTC_14 0354-0009 295 µM 0.828770293565902 0.249320631950645 no 832 0.203617200430233 1010 1713507 SGTC_3172 9105863 49.47 µM 0.827757783930606 0.249589028447135 no 833 0.203903843593816 986 2348785 SGTC_1467 k284-1082 293 µM 0.825102351500386 0.250293660147384 no 834 0.204656742406273 1014 3334705 SGTC_1493 4348-0038 111 µM 0.824655763837499 0.250412267841432 no 835 0.204783526355264 1076 800424 SGTC_3293 9120939 62.045 µM 0.8228121475009 0.250902222779771 no 836 0.205307413835278 977 934087 SGTC_129 0088-0017 176.636 µM 0.822022809037329 0.251112150449111 no 837 0.205531957775058 972 182446 SGTC_2360 9040895 200 µM 0.820606201094563 0.251489135784246 no 838 0.205935307182259 949 4914414 SGTC_48 0382-0018 55 µM 0.81991795148637 0.25167239950536 no 839 0.206131441182079 1020 762596 SGTC_2835 9006588 71.43 µM 0.819245310345083 0.25185157520951 no 840 0.206323234131308 941 2345538 SGTC_1106 tegaserod maleate 11.7 µM 0.819144634949811 0.251878398548052 no 841 0.206351949219281 1017 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2558 carylophyllene oxide 100 µM 0.81815257166303 0.252142798464756 no 842 0.206635036592089 1101 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2378 9074213 121.43 µM 0.818108484722644 0.252154551699635 no 843 0.206647622229659 1041 657714 SGTC_3240 9133527 49.47 µM 0.817022022625331 0.2524442853122 no 844 0.206957921398363 973 17617455 SGTC_2873 9040596 71.43 µM 0.815896117003187 0.25274472259034 no 845 0.207279776590685 1035 6463863 SGTC_1999 st074831 12.5 µM 0.815798953238003 0.252770658645188 no 846 0.207307566020397 1000 17112523 SGTC_1051 3253-3903 78 µM 0.815280539626225 0.252909063170478 no 847 0.207455872705448 1053 5509239 SGTC_3115 9123671 49.47 µM 0.814305735325997 0.253169421499277 no 848 0.207734912459186 1103 3286988 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 0.814143571846804 0.253212747056341 no 849 0.207781353591108 1029 2333 A French combination drug. SGTC_2389 9091542 195.52 µM 0.813164451588053 0.253474423488805 no 850 0.208061888873574 995 3626624 YOL127W RPL25 SGTC_1017 4239-0030 168 µM 0.810433567405566 0.254205020738758 no 851 0.208845515963854 999 1149593 SGTC_2874 9043904 71.43 µM 0.808797442556701 0.254643263887447 no 852 0.209315833757616 930 4463428 SGTC_1501 4491-0275 38.4 µM 0.807885267349067 0.254887765666819 no 853 0.209578316586725 1041 5104718 SGTC_2442 5158906 48.48 µM 0.806840755683521 0.255167890073836 no 854 0.209879117516857 1034 1893835 SGTC_544 k015-0020 52.4 µM 0.806790170938395 0.255181460328815 no 855 0.20989369147026 1000 3008304 SGTC_3309 9129340 25.759 µM 0.80504029632399 0.255651127459801 no 856 0.210398213323566 1059 17158987 SGTC_728 3030-5151 22.5 µM 0.804448899890615 0.255809960530705 no 857 0.210568884900004 994 3125388 SGTC_1530 rhein 70.4 µM 0.80341518390535 0.256087712313839 no 858 0.210867400868927 1099 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_911 3456-4043 236 µM 0.802430617292466 0.256352404204923 no 859 0.211151954122112 1062 914281 SGTC_722 3534-0461 190 µM 0.802203688939861 0.256413432067311 no 860 0.211217571423334 1063 658262 SGTC_3298 9116858 71.43 µM 0.802002358527331 0.256467582210384 no 861 0.211275796971929 1041 2506942 SGTC_2016 5121758 140 µM 0.801730517154562 0.256540706543895 no 862 0.211354429486199 1090 2795203 SGTC_1040 k898-0338 155 µM 0.800060155405479 0.256990266008389 no 863 0.2118379724899 1100 20969351 SGTC_1863 st057641 20.1 µM 0.799906011400765 0.257031772814416 no 864 0.211882627310274 1086 3921635 SGTC_2875 9039966 71.43 µM 0.799339012247992 0.257184480329379 no 865 0.212046931773661 1067 6463691 SGTC_1134 3477-0009 42.5 µM 0.791003539326031 0.259434870497775 no 866 0.214470963065396 1070 3973534 SGTC_2372 9071633 200 µM 0.787265274973551 0.260447411334693 no 867 0.215563296438743 1113 21321366 SGTC_2336 9001819 198.65 µM 0.78708593645767 0.260496037814003 no 868 0.215615780730449 1076 2989602 SGTC_1192 1488-0095 21.4 µM 0.784895228260169 0.261090411300085 no 869 0.216257500004979 1007 915875 SGTC_1342 1486-1464 234 µM 0.784547918208255 0.261184705943747 no 870 0.216359338216606 1100 3253938 SGTC_1838 st055369 84.5 µM 0.782554787147417 0.261726179015424 no 871 0.216944300352626 1076 676036 SGTC_3196 9111891 49.47 µM 0.782059335748495 0.261860867410652 no 872 0.217089851646205 1099 18891510 SGTC_193 1273-0060 1.558 µM 0.782000086847811 0.261876976595608 no 873 0.21710726127545 950 2847393 YHR072W ERG7 SGTC_3146 9095609 49.47 µM 0.781683961709 0.261962936455967 no 874 0.217200164758149 1043 17173999 SGTC_3094 9117742 49.47 µM 0.778845347620298 0.262735452073145 no 875 0.218035410584977 1090 17149698 SGTC_1990 st072050 59.8 µM 0.778836045383867 0.262737985547863 no 876 0.218038150754804 1111 17233948 SGTC_2833 9001315 45.46 µM 0.778741761340935 0.26276366461986 no 877 0.21806592522743 1032 2989378 SGTC_2622 2-methoxyxanthone 59.94 µM 0.777110978462117 0.263208025435847 no 878 0.218546648687076 1077 71034 A hepatoprotective. SGTC_1060 3448-7350 82 µM 0.776943341217514 0.263253725504374 no 879 0.218596099487738 1037 570178 SGTC_2922 7999257 32.47 µM 0.775951205751352 0.263524277334469 no 880 0.218888898357756 1021 2988377 SGTC_679 0422-0091 41.4 µM 0.77593516719952 0.263528652156008 no 881 0.218893633505203 1134 627384 YHR062C RPP1 SGTC_1661 st013063 9.66 µM 0.775268005766759 0.26371066601922 no 882 0.219090655346809 1133 721395 SGTC_1684 st024538 14.6195 µM 0.773406311218587 0.264218909290911 no 883 0.219640978023353 1066 6732859 SGTC_1427 4048-4900 550 nM 0.770760815027571 0.264941987803114 no 884 0.220424358701899 1090 24132586 SGTC_1526 st051518 75 µM 0.770648845024104 0.264972614097667 no 885 0.220457550390735 973 673993 SGTC_1197 1601-0112 267 µM 0.770285805494371 0.265071925880645 no 886 0.220565187260042 1100 7350313 SGTC_3143 9086658 49.47 µM 0.767937491217535 0.265714778649381 no 887 0.221262161206035 1112 25236626 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.767271431153005 0.265897256868889 no 888 0.221460075288236 1127 551469 SGTC_235 0330-0087 5 mM 0.765036279487402 0.266510077534747 no 889 0.222124970784537 1120 46494818 YHR062C RPP1 SGTC_1112 tnp00069 1.16933 µM 0.764247084296456 0.266726624920854 no 890 0.222360006312543 1126 145826 SGTC_3207 9114163 49.47 µM 0.76398322740364 0.266799044485478 no 891 0.222438618941744 1126 849233 SGTC_3156 9099931 49.47 µM 0.763965531399432 0.266803901780331 no 892 0.22244389179644 1115 18111053 SGTC_87 0100-0052 35.5 µM 0.763579562039423 0.266909855851212 no 893 0.222558916302374 1203 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2400 5203494 178.7 µM 0.761101110659179 0.267590732041391 no 894 0.2232983385731 1060 6777674 SGTC_546 peri-Naphthalide 147 µM 0.759491610149116 0.268033359898495 no 895 0.22377926548636 1067 223824 A penicillin ester. SGTC_2994 9053520 71.4286 µM 0.759206226535579 0.268111881545919 no 896 0.223864600970741 1086 4647384 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.758191829851371 0.268391080600979 no 897 0.224168075795053 1168 6710655 SGTC_357 1325-0123 420 µM 0.757973572727065 0.268451172049669 no 898 0.224233401827236 1087 1098503 SGTC_31 0508-1974 57.237 µM 0.755380945790175 0.269165501805963 no 899 0.225010221321114 1080 6810525 SGTC_2691 st077356 60.2 µM 0.754142073887478 0.269507176577327 no 900 0.22538195789159 1123 2839272 SGTC_3239 9133757 49.47 µM 0.7535834454655 0.269661314620091 no 901 0.225549693916595 1110 17036923 SGTC_215 1287-0124 461.5 µM 0.753295102649379 0.269740892111011 no 902 0.225636300531865 1102 5560863 SGTC_353 1988-1175 58.3 µM 0.753253157587603 0.269752469182119 no 903 0.225648900713361 1016 2788357 SGTC_3198 9112019 49.47 µM 0.75312277541452 0.269788456978242 no 904 0.225688069702515 1111 45595555 SGTC_1808 st050063 61.5 µM 0.752850898952008 0.269863507444549 no 905 0.225769758318928 1101 4011993 SGTC_808 0711-0032 135 µM 0.752368762338303 0.269996625125266 no 906 0.225914663294806 1106 4252555 SGTC_131 0141-0277 33.849 µM 0.752300409172623 0.270015500059671 no 907 0.225935210926331 1065 1547771 SGTC_571 k831-0106 44.2 µM 0.751567300760926 0.270217980957507 no 908 0.22615565693103 1076 4783639 SGTC_1870 st057514 26.5 µM 0.750987635297068 0.270378135413166 no 909 0.226330048591931 1114 5393161 SGTC_2154 5570129 200 µM 0.750434684402668 0.270530953163353 no 910 0.226496473971383 1141 673366 SGTC_2497 7-hydroxyflavone 100 µM 0.750375726057045 0.270547249889372 no 911 0.226514223139867 1041 5281894 SGTC_941 3237-0776 460 µM 0.750161256010075 0.270606535872393 no 912 0.226578795092652 1112 760008 SGTC_3023 9089636 49.47 µM 0.750046434810087 0.270638278578397 no 913 0.226613369360889 1215 17249241 SGTC_2821 7996764 71.43 µM 0.749904172588322 0.270677610026132 no 914 0.226656210634524 1189 2987135 SGTC_696 1560-0013 611 µM 0.74928312147683 0.270849346371894 no 915 0.226843289361028 1129 1650269 SGTC_2345 9052315 157.45 µM 0.749054964682387 0.270912451154574 no 916 0.226912038720918 1077 6469265 SGTC_1037 k284-1091 78.7 µM 0.745432965642226 0.271915223974713 no 917 0.228005010673719 1100 3334711 SGTC_1675 st018485 24.5 µM 0.744933338661158 0.27205369356947 no 918 0.228156009834519 1103 3323024 SGTC_633 0437-0093 97.7 µM 0.74401220587904 0.2723090736647 no 919 0.228434545410957 1154 2831118 SGTC_731 3966-0296 387 µM 0.743511086015072 0.272448056994606 no 920 0.228586156116997 1162 660956 SGTC_259 usnic acid 108.925 µM 0.742451286866049 0.272742103484162 no 921 0.228906977847197 1172 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1410 3909-8106 77.9 µM 0.742243592056511 0.272799747878949 no 922 0.228969880689223 1138 1039210 SGTC_724 3910-0327 137 µM 0.741421884133431 0.273027867010564 no 923 0.22921883977173 1141 2885483 SGTC_1826 st055655 41.6 µM 0.741247544226734 0.273076278686536 no 924 0.229271680368178 1096 676168 SGTC_980 1473-0395 201 µM 0.739936902746536 0.273440361074786 no 925 0.229669140642233 1085 768876 SGTC_2453 5731132 22.18 µM 0.737381420983364 0.274150937357877 no 926 0.230445215286273 1163 1362040 SGTC_1957 st077035 62.4 µM 0.737242508450789 0.274189589447185 no 927 0.230487443622606 1180 705593 SGTC_108 0509-0257 621.132 µM 0.735209170404418 0.274755668883174 no 928 0.23110605745695 1126 536624 SGTC_78 0336-0123 156.75 µM 0.734447726837474 0.274967802262395 no 929 0.231337953943414 1008 6765896 SGTC_1323 1348-1351 11.2 µM 0.732940696255666 0.275387889245529 no 930 0.231797300208891 1080 6989654 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.730843839113393 0.275972916119834 no 931 0.232437271386115 1136 6708739 YPR165W RHO1 SGTC_26 0302-0163 425.158 µM 0.727606315854322 0.276877387926407 no 932 0.233427306633327 1172 3100915 SGTC_991 3996-0057 64.7 µM 0.727562776066915 0.276889561588917 no 933 0.233440637031499 1099 715343 SGTC_1259 0671-0132 43 µM 0.72475519181802 0.277675111048959 no 934 0.234301114620573 1096 X1259 SGTC_1364 1653-0028 37.6 µM 0.724195752202079 0.2778317697114 no 935 0.234472783019488 1115 5718652 SGTC_2471 5466956 24.79 µM 0.7232493937591 0.278096874609816 no 936 0.234763338827714 1112 724419 SGTC_851 0394-0702 453 µM 0.722966060265055 0.27817626926818 no 937 0.23485036802826 1177 762646 SGTC_1534 6-azauridine 81.6 µM 0.719941732852877 0.279024423084277 no 938 0.235780435770195 1194 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_1180 1193-0155 285 µM 0.719113747690888 0.279256845475236 no 939 0.23603541870037 1153 2921347 SGTC_2652 actinonin 100 µM 0.718884974237113 0.279321080691171 no 940 0.236105897620107 1147 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1392 3455-1037 33.9 µM 0.717513572654379 0.279706294495104 no 941 0.236528632355655 1160 981132 SGTC_100 0086-0128 49.5915 µM 0.717229058987513 0.279786243985355 no 942 0.236616385873714 1151 93297 SGTC_1354 1498-1681 81 µM 0.715363772500456 0.280310671451208 no 943 0.237192145956651 1195 5754243 SGTC_693 4161-2696 114 µM 0.713707819486767 0.280776643133945 no 944 0.237703935079192 1151 805759 SGTC_2441 5730946 39.09 µM 0.711748386572545 0.281328494965919 no 945 0.238310299460433 1175 1774275 SGTC_877 0771-0151 33.1 µM 0.711723596421621 0.281335480180415 no 946 0.238317976422004 1161 6166523 SGTC_781 4335-2806 94.4 µM 0.711172127801894 0.281490891218519 no 947 0.238488789076386 1243 845254 SGTC_2496 diffractaic acid 79.83 µM 0.710610849963433 0.281649109139226 no 948 0.238662708853959 1190 94870 An apoptosis inducer which activates caspases. SGTC_2201 6605497 169.863 µM 0.708272687088723 0.282308671996729 no 949 0.239387967501102 1169 670741 SGTC_441 propafenone 146 µM 0.708176120578083 0.282335928023304 no 950 0.239417946663808 1162 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1408 3909-7976 48.8 µM 0.707820453231324 0.282436326523907 no 951 0.239528381601881 1216 24152374 SGTC_3043 9092303 49.47 µM 0.705197587005804 0.283177244243955 no 952 0.240343641375817 1146 25236084 SGTC_1137 ixabepilone 100 µM 0.704684094334725 0.283322406780295 no 953 0.240503425938332 1191 154225 A novel microtubule stabilizer. SGTC_1387 3342-1166 1.8 µM 0.704600602540361 0.283346012983389 no 954 0.240529411716712 1140 3418228 SGTC_117 lucigenin 22.078 µM 0.70280491523569 0.28385394800041 no 955 0.241088666827913 1184 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_3268 9137683 49.47 µM 0.701753301208239 0.284151613821598 no 956 0.241416513128385 1168 1953228 SGTC_2564 betulinic acid 100 µM 0.701525999949744 0.284215972455488 no 957 0.241487407329009 1224 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_819 1013-0258 27.7 µM 0.700889925667987 0.284396109112636 no 958 0.241685856004792 1213 5753198 SGTC_2811 7967822 32.47 µM 0.700172334062835 0.284599396995188 no 959 0.241909843480009 1179 2232244 SGTC_879 0831-1030 162 µM 0.698565051091477 0.285054978815458 no 960 0.242411945619783 1217 1549252 SGTC_218 alverine citrate 93.75 µM 0.698013140252537 0.285211497229011 no 961 0.242584488215779 1174 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_3124 9127567 49.47 µM 0.695144751692509 0.286025612843368 no 962 0.243482295868398 1159 17592030 SGTC_3322 9139058 2.11 µM 0.694111760282743 0.286319070139068 no 963 0.243806061984115 1220 4908926 YPR165W RHO1 SGTC_2117 5521686 200 µM 0.691632425263609 0.287023994518197 no 964 0.244584096688928 1208 803312 SGTC_1358 1509-0022 2.48 µM 0.690981051771734 0.287209329241535 no 965 0.244788724372899 1219 3258434 SGTC_3006 9075424 71.4286 µM 0.689449024036372 0.287645458881786 no 966 0.245270370886377 1192 7465181 SGTC_2216 7189485 200 µM 0.687685033582839 0.288148009790874 no 967 0.245825573405637 1209 731273 SGTC_909 3448-9333 149 µM 0.687145067993757 0.288301925705032 no 968 0.245995658207637 1164 3344074 SGTC_964 1287-0107 19.4 µM 0.686456865662758 0.288498152329277 no 969 0.246212527873034 1212 51516812 YPR165W RHO1 SGTC_1620 st003704 16.5 µM 0.686209917693556 0.288568579763055 no 970 0.246290372304493 1196 2834414 SGTC_598 3937-0236 20.2 µM 0.685644535402314 0.288729852416983 no 971 0.246468645201178 1238 1379313 SGTC_868 0527-0199 213 µM 0.684606416459838 0.289026081443794 no 972 0.24679615848953 1163 2849450 SGTC_889 0919-1524 82.7 µM 0.684006242481108 0.289197407315121 no 973 0.246985611960818 1198 3905452 SGTC_3346 9158254 43.5805 µM 0.683883649559191 0.289232408604285 no 974 0.247024319732965 1177 17639500 SGTC_2349 9023730 187.07 µM 0.683175040736668 0.289434761270277 no 975 0.247248121102608 1204 4126287 SGTC_1456 k015-0012 13 µM 0.682963442606636 0.289495198819549 no 976 0.247314971585966 1281 2989616 SGTC_2450 5739737 12.93 µM 0.682432698569963 0.289646818238849 no 977 0.247482692772639 1217 2262825 SGTC_1935 st074532 41.6 µM 0.678923019221621 0.290650377029146 no 978 0.248593319746424 1283 2829742 SGTC_3013 9080133 71.4286 µM 0.678081794370307 0.290891158549769 no 979 0.248859916619547 1295 17050193 SGTC_2418 pentamidine 31.67 µM 0.677059016256019 0.291184031089041 no 980 0.249184255358904 1213 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2596 sinensetin 100 µM 0.677020209230791 0.291195146192222 no 981 0.24919656609138 1208 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_338 4055-0136 114 µM 0.675766971385409 0.29155420486403 no 982 0.249594303911344 1191 2900563 SGTC_2751 anetholtrithion 17.25 µM 0.675411145379862 0.291656188343827 no 983 0.249707293201737 1197 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_1286 0929-0070 131 µM 0.6749982972507 0.291774535799923 no 984 0.249838423379664 1282 1420408 SGTC_130 0136-0219 337.655 µM 0.674612870694307 0.291885042752793 no 985 0.249960876814632 1191 234244 SGTC_1266 0828-0227 32.9 µM 0.67375006189385 0.292132492223846 no 986 0.250235114237902 1195 3913820 SGTC_1382 3002-2117 298 µM 0.67327839099256 0.292267806459726 no 987 0.250385098782757 1268 1497314 SGTC_2133 5320837 200 µM 0.672804025161323 0.292403923221767 no 988 0.250535988323015 1214 2841355 SGTC_244 nsc-207895 1.295 µM 0.672324550876834 0.292541535771129 no 989 0.250688551740784 1131 42640 SGTC_2358 9037157 4 µM 0.672286686730479 0.292552404334054 no 990 0.250700601789493 1242 2388925 SGTC_454 lyso-paf C-16 6.67 µM 0.671537480763281 0.292767495750824 no 991 0.250939095386997 1171 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_770 0389-1121 67.2 µM 0.670171075014412 0.29315996956871 no 992 0.251374370259903 1301 6753108 SGTC_984 1492-0255 2.91 µM 0.669291880626734 0.293412630199458 no 993 0.25165465256913 1187 1585198 SGTC_2949 9072542 2.23 µM 0.668697781628829 0.293583417944677 no 994 0.251844141457314 1252 16457352 SGTC_1681 tripelennamine 100 µM 0.667251133279486 0.293999483454896 no 995 0.252305867233676 1239 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1237 0330-0133 46.1 µM 0.667017277516066 0.294066767487381 no 996 0.25238054870134 1199 X1237 YHR072W ERG7 SGTC_1972 st070201 17.4 µM 0.666100120136408 0.294330716961333 no 997 0.25267355387894 1233 2829099 SGTC_2657 nystatin 74.44 µM 0.665557137227198 0.294487033998934 no 998 0.252847105559077 1256 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2561 acetosyringone 100 µM 0.665189120901843 0.294593002432321 no 999 0.252964768965776 1240 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1745 st081495 74 µM 0.664695855106165 0.294735063401059 no 1000 0.253122522731567 1199 13842402 YBL026W LSM2 SGTC_2979 9012552 45.46 µM 0.663936154459174 0.294953919604825 no 1001 0.253365587524748 1304 17100905 SGTC_555 4296-0685 37 µM 0.661839474313037 0.295558323919058 no 1002 0.254037052413553 1221 2908540 YHR072W ERG7 SGTC_1778 st046819 58.9 µM 0.661133711993122 0.295761900139808 no 1003 0.254263283667152 1283 671715 SGTC_961 1252-1571 372 µM 0.660154305557276 0.296044515333895 no 1004 0.254577406124541 1266 6813498 SGTC_2790 5423970 71.43 µM 0.65933660389478 0.296280564282284 no 1005 0.254839821059667 1282 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_1093 fluphenazine 7.97 µM 0.659055008046641 0.29636187356784 no 1006 0.254930222914927 1298 6602611 An atypical antipsychotic. SGTC_3113 9123498 49.47 µM 0.657093336410639 0.296928579338647 no 1007 0.255560451654426 1295 8897275 SGTC_2773 thioridazine 9.09 µM 0.656935197619491 0.296974285517254 no 1008 0.255611292529836 1264 5452 An antipsychotic. SGTC_640 3381-0960 37.1 µM 0.655269481600127 0.297455915664293 no 1009 0.256147133067562 1292 1745025 SGTC_1245 0418-0076 17.2 µM 0.655236358173517 0.297465496687802 no 1010 0.256157794406949 1263 6790114 SGTC_2840 9008771 71.43 µM 0.646786393795767 0.299914256239046 no 1011 0.258885099762463 1247 2992978 SGTC_2031 5180455 200 µM 0.64675001138445 0.299924819390859 no 1012 0.258896874924078 1238 29949 SGTC_297 0986-0032 24 µM 0.645662057706389 0.300240770117677 no 1013 0.259249118942554 1238 2847425 SGTC_3016 9080866 49.47 µM 0.645287961184045 0.300349445588457 no 1014 0.259370296430666 1268 17066299 SGTC_1207 2099-0101 141 µM 0.645012121560686 0.300429588700653 no 1015 0.259459665245954 1287 5837381 SGTC_762 1165-0429 115 µM 0.641872949041647 0.301342331206639 no 1016 0.260477839742206 1297 5967793 SGTC_1713 st033146 12.748 µM 0.641338495845706 0.301497852553961 no 1017 0.260651391638514 1295 674619 SGTC_2762 leflunomide 42.06 µM 0.64130933723961 0.301506338499949 no 1018 0.260660861965052 1290 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2677 mitomycin C 100 µM 0.640947452177849 0.301611665820295 no 1019 0.260778412145115 1287 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_319 1348-1596 45.5 µM 0.639008797470311 0.302176196462854 no 1020 0.261408604397908 1347 5380505 SGTC_1903 st060211 78.3 µM 0.637115687284573 0.302727921905813 no 1021 0.262024745514173 1304 688960 SGTC_3089 9117425 49.47 µM 0.636204900007907 0.30299352117252 no 1022 0.262321439912198 1217 9401657 SGTC_2179 6298986 200 µM 0.635409731559535 0.303225489473995 no 1023 0.262580611399738 1275 738374 SGTC_1291 0993-0025 5.79 µM 0.635026526475679 0.303337307255857 no 1024 0.262705557286827 1311 4353356 SGTC_1747 st037496 66.6 µM 0.634674433612762 0.303440062852002 no 1025 0.262820385688385 1313 723305 SGTC_3228 9131799 49.47 µM 0.633856604720457 0.303678799916665 no 1026 0.263087204071086 1294 17015818 SGTC_3125 9127534 49.47 µM 0.633307671052735 0.30383908925962 no 1027 0.263266372428307 1192 1639235 SGTC_2143 5623677 140.463 µM 0.631716538081907 0.30430391524223 no 1028 0.263786059696861 1261 5375313 SGTC_560 2332-1943 155 µM 0.629259279510243 0.305022388410765 no 1029 0.264589662739669 1291 21177716 SGTC_1451 4152-0210 104 µM 0.62743515540215 0.305556227276072 no 1030 0.265187014695291 1327 659563 SGTC_1973 st070275 50.2 µM 0.625963471463091 0.305987224355719 no 1031 0.265669450545105 1260 17118334 SGTC_1631 benzylvanillin 81.9 µM 0.624828329250192 0.306319845532222 no 1032 0.266041867710305 1318 75506 SGTC_1911 st060208 74.3 µM 0.624585912025065 0.306390899713574 no 1033 0.266121434141436 1346 688783 SGTC_579 4491-1009 110 µM 0.624578240886501 0.306393148296705 no 1034 0.266123952167105 1411 1271041 SGTC_182 3448-4371 550.524 µM 0.620743264520824 0.307518177503207 no 1035 0.267384279099058 1352 3491403 SGTC_1640 st009078 66.4 µM 0.619151827500812 0.307985574614635 no 1036 0.267908171643347 1343 690618 SGTC_322 k048-0136 19.3 µM 0.618590480757557 0.308150513742602 no 1037 0.268093087242696 1312 6823282 SGTC_569 4130-2812 160 µM 0.618532772740994 0.308167472143781 no 1038 0.268112100725006 1252 743552 SGTC_948 3448-0295 75.3 µM 0.618524903436282 0.308169784693498 no 1039 0.268114693534973 1332 678569 SGTC_399 oxolinic acid 75 µM 0.615673959528602 0.309008091063526 no 1040 0.269054863635629 1285 4628 A DNA gyrase inhibitor. SGTC_2387 9077560 195.08 µM 0.614540924697299 0.309341531263038 no 1041 0.26942896913966 1281 5303272 SGTC_208 k072-0098 12.366 µM 0.612839325266664 0.309842589038863 no 1042 0.269991292768464 1317 5948901 SGTC_2385 9074692 200 µM 0.612837133043305 0.309843234795321 no 1043 0.269992017606085 1290 17046906 SGTC_1735 st034310 56.75 µM 0.612815000057334 0.30984975447345 no 1044 0.2699993357201 1409 871153 SGTC_1474 0330-0125 5.35 µM 0.612392483018878 0.30997422610532 no 1045 0.270139056997681 1324 X1474 SGTC_3158 9100007 49.47 µM 0.611588982592667 0.31021099383369 no 1046 0.270404864623803 1305 19297233 SGTC_2905 7799065 20.05 µM 0.609490619960254 0.310829689946164 no 1047 0.271099644136967 1292 1296806 SGTC_829 1635-0120 117 µM 0.608885610770473 0.311008174626407 no 1048 0.271300131260898 1351 285054 SGTC_2522 biochanin a 4.94 µM 0.608872733925826 0.311011973927294 no 1049 0.271304399175197 1301 5280373 A possible chelator. SGTC_410 α-linolenic acid 100 µM 0.607822019372699 0.311322054112704 no 1050 0.271652761782034 1358 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2052 5265182 7.135 µM 0.606130408723896 0.3118215527721 no 1051 0.272214079860686 1379 1239884 SGTC_13 0199-0087 65 µM 0.605913156657534 0.311885728060484 no 1052 0.272286211194673 1351 4589825 SGTC_1148 3909-7663 27.7 µM 0.605650189399328 0.311963415052737 no 1053 0.272373533442888 1383 4084526 SGTC_3191 9110352 49.47 µM 0.601916069215334 0.313067467382402 no 1054 0.273615003608787 1360 17122424 SGTC_2844 9010103 25.97 µM 0.600346564662144 0.313532018016699 no 1055 0.274137645886422 1341 2480525 SGTC_689 0833-0039 98 µM 0.599888594375403 0.313667626396782 no 1056 0.274290242085757 1343 5374726 SGTC_550 4123-0385 25.7 µM 0.599137713912411 0.313890022125902 no 1057 0.274540526995865 1323 5731123 SGTC_1288 0973-0013 65.5 µM 0.59803570441923 0.314216537671287 no 1058 0.274908054815071 1386 4315430 SGTC_2513 baicalein 25.65 µM 0.597924936424694 0.314249365284751 no 1059 0.274945010116367 1290 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_2871 9038510 12.99 µM 0.597655073875769 0.314329348900203 no 1060 0.275035054056153 1404 4945164 SGTC_406 estrone 100 µM 0.59723612682774 0.314453536420001 no 1061 0.275174871188927 1420 5870 A steroid. SGTC_1505 k297-0037 20.6 µM 0.594542606280386 0.315252471609334 no 1062 0.276074627151485 1321 4089396 SGTC_2788 5282734 71.43 µM 0.594524148634801 0.315257949387932 no 1063 0.276080797807637 1446 743706 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.594037719597625 0.315402324287014 no 1064 0.276243442427294 1404 688801 SGTC_2683 piperine 63.03 µM 0.594029235948242 0.315404842532467 no 1065 0.276246279475903 1317 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1899 st063254 59.6 µM 0.592678200545468 0.31580598669512 no 1066 0.276698266577222 1283 3093813 SGTC_1065 prochlorperazine maleate 2.48 µM 0.592497653945621 0.315859610338275 no 1067 0.276758695639666 1374 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_1821 st053465 65.6 µM 0.592397548425047 0.315889344070547 no 1068 0.276792203807392 1294 675086 SGTC_963 1269-2853 151 µM 0.591003716321693 0.316303469217016 no 1069 0.277258965454957 1325 3668223 SGTC_3224 9130643 49.47 µM 0.590677103094839 0.316400543490747 no 1070 0.277368396206957 1397 17644395 SGTC_2848 9016370 25.97 µM 0.590539676869648 0.316441392376112 no 1071 0.277414446750234 1369 7894410 SGTC_870 0573-2213 57.6 µM 0.588334911300441 0.317097047823077 no 1072 0.27815375846427 1340 3916321 SGTC_2938 9059746 27.26 µM 0.58666493628494 0.317594049305729 no 1073 0.278714380673588 1366 6471769 SGTC_2934 9036370 36.88 µM 0.585814396046002 0.317847305184297 no 1074 0.279000124214013 1391 6462800 SGTC_2034 5197015 53.07 µM 0.581394570928213 0.319164717241877 no 1075 0.280487277821931 1449 780676 SGTC_1805 st050013 60.3 µM 0.581108300840359 0.319250124463794 no 1076 0.280583732243072 1357 4037144 SGTC_2100 5377183 190 µM 0.58010824320473 0.319548561832154 no 1077 0.280920812606595 1407 2844202 SGTC_3330 9141424 71.43 µM 0.578315356734711 0.320083887888684 no 1078 0.281525614149725 1408 27261020 SGTC_969 1313-0238 134 µM 0.577768402245912 0.320247274054136 no 1079 0.281710245447006 1397 5212874 SGTC_1230 0170-0365 3.77 µM 0.577510311789423 0.320324382904185 no 1080 0.281797387360699 1430 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1676 st018489 23.4 µM 0.577298022518597 0.320387813697862 no 1081 0.281869074653821 1393 3696235 SGTC_1848 st056003 16.4 µM 0.577211076716862 0.320413794110211 no 1082 0.281898437643153 1406 146492 SGTC_430 0958-0115 16.4 µM 0.576985041640421 0.320481340126466 no 1083 0.281974780202557 1377 6833180 SGTC_3264 9137442 49.47 µM 0.575379298625473 0.320961355050413 no 1084 0.282517400775256 1439 17015726 SGTC_1548 st061468 90.8 µM 0.575032606473895 0.321065033256335 no 1085 0.282634622559756 1372 390799 SGTC_1094 duloxetine 25.4 µM 0.574948528708135 0.321090178794507 no 1086 0.282663054027293 1373 60834 A selective serotonin reuptake inhibitor. SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.573024533692454 0.321665821156838 no 1087 0.283314041328218 1379 5106787 A p450 inhibitor. SGTC_2048 5246248 200 µM 0.572920168159391 0.321697058666451 no 1088 0.283349374148567 1379 677046 SGTC_777 1315-0167 517 µM 0.572090711248406 0.321945367120179 no 1089 0.283630260844526 1330 4221767 SGTC_1117 retinoic acid 1.10837 µM 0.571382726739971 0.322157374180782 no 1090 0.283870117680247 1467 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_3276 9139060 49.47 µM 0.571317003145525 0.322177058150063 no 1091 0.283892388986116 1421 4870619 SGTC_828 2074-0507 139 µM 0.570063230996555 0.322552653645457 no 1092 0.284317406264478 1457 X828 SGTC_2670 beta-carotene 100 µM 0.569052274823689 0.322855640140176 no 1093 0.284660332473123 1329 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_507 nimesulide 162 µM 0.567160741892338 0.323422853837873 no 1094 0.285302488763816 1434 4495 A COX2 inhibitor. SGTC_1391 3442-0225 151 µM 0.566112659096858 0.323737319152856 no 1095 0.285658599139064 1384 5227075 SGTC_2995 9067767 71.4286 µM 0.565867195039531 0.323810986051226 no 1096 0.285742031787167 1397 11673567 SGTC_3082 9117008 49.47 µM 0.565681176990241 0.323866817041163 no 1097 0.285805266598342 1384 41448529 SGTC_1234 0326-0494 15.5 µM 0.56488715707896 0.324105176732094 no 1098 0.286075259830413 1461 1547813 SGTC_1126 isoteolin 1.0172 µM 0.564407284327328 0.324249266430382 no 1099 0.286238491289232 1345 133323 SGTC_1618 st003135 44.5 µM 0.56396557992075 0.324381918722843 no 1100 0.286388778648685 1355 1270615 SGTC_570 0987-0065 62.6 µM 0.56019031622693 0.325516610663468 no 1101 0.287674815760369 1317 3104428 SGTC_2676 harmalol 100 µM 0.559682122742804 0.325669476982498 no 1102 0.287848139196805 1442 5459187 A monoamine oxidase inhibitor SGTC_721 1187-1332 279 µM 0.55816137443253 0.326127098287566 no 1103 0.288367096930613 1345 25730 SGTC_1796 st049173 110.4 µM 0.55753273142462 0.326316345166401 no 1104 0.288581751123657 1355 94134 SGTC_788 1182-0090 188 µM 0.557507414610751 0.326323967484763 no 1105 0.288590397288965 1543 5715185 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.55605214852763 0.326762236926293 no 1106 0.289087602868363 1421 2724278 An inhibitor of dopamine biosynthesis. SGTC_1087 pterostilbene 9.05 µM 0.555472517440117 0.326936865852305 no 1107 0.28928575150059 1502 5281727 Similar to reservatol, lowers cholesterol. SGTC_2190 6049624 200 µM 0.555011369907491 0.327075825606867 no 1108 0.289443441751543 1393 2265554 SGTC_2678 equilin 100 µM 0.554840317860588 0.327127375621885 no 1109 0.289501943579325 1481 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_1292 0kpi-0043 232 µM 0.553931781283691 0.327401236868879 no 1110 0.289812766898368 1375 3333905 SGTC_2959 9079155 11 µM 0.553364979207881 0.327572135759347 no 1111 0.290006757238207 1405 16189457 SGTC_3231 9132313 49.47 µM 0.553183877988765 0.327626747972326 no 1112 0.290068752704978 1433 4905967 SGTC_2745 rifampicin 24.3 µM 0.551828438252805 0.32803560638497 no 1113 0.290532950663171 1433 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_1320 1313-0481 95.3 µM 0.548641390595586 0.328997767376346 no 1114 0.291625787513339 1422 6813365 YLR208W SEC13 SGTC_1018 4259-0013 28.1 µM 0.545798835660447 0.329856884170045 no 1115 0.292602111862942 1439 6801262 SGTC_1741 st038134 10.228 µM 0.545479834365208 0.329953353357213 no 1116 0.292711773048918 1536 1272587 SGTC_2183 6420625 130.508 µM 0.544304210784573 0.330308971305714 no 1117 0.293116074902336 1400 2897619 SGTC_415 dibenzyl ketone 100 µM 0.543058393183482 0.330685989787202 no 1118 0.293544799197299 1523 7593 SGTC_25 0118-0223 35.662 µM 0.542750251280391 0.330779268478752 no 1119 0.293650885115371 1466 5333628 SGTC_2638 epoxomicin 18 µM 0.542552570303748 0.330839114698338 no 1120 0.293718951310607 1480 9915668 A protesome inhibitor. SGTC_2293 7624732 200 µM 0.540454295228137 0.331474615726103 no 1121 0.294441886261427 1364 894453 SGTC_1996 st072960 66.8 µM 0.53870226980865 0.332005620748933 no 1122 0.295046153649151 1412 1719405 SGTC_966 1300-0360 30.2 µM 0.538284390686366 0.332132321728413 no 1123 0.295190363009906 1428 70588 SGTC_1738 st035555 74 µM 0.536476572836499 0.332680673191887 no 1124 0.295814611348665 1428 5331140 SGTC_2305 7443522 69.23 µM 0.53195268357927 0.33405443714314 no 1125 0.297379383623206 1453 5415886 SGTC_1084 voriconazole 435 nM 0.530574394083982 0.3344734239983 no 1126 0.297856871824035 1452 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2313 7726885 200 µM 0.528663825423224 0.335054559686288 no 1127 0.298519337907333 1433 726423 SGTC_2620 irigenin 100 µM 0.527925599162478 0.335279211105706 no 1128 0.298775488151319 1541 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_895 0964-0006 13.7 µM 0.527844444965219 0.335303910931933 no 1129 0.298803653182606 1408 6738897 SGTC_1430 4049-0248 69.1 µM 0.527432784037803 0.335429213670444 no 1130 0.298946541056884 1522 22774488 SGTC_960 1222-0186 7.7 µM 0.526362220528183 0.335755161081066 no 1131 0.299318279826982 1513 3126296 SGTC_2654 protoveratrine a 100 µM 0.526155906045228 0.335817990503434 no 1132 0.299389943845342 1429 5702278 A heart drug and vasodilator. SGTC_802 4112-3352 742 µM 0.525858207886674 0.335908657294001 no 1133 0.29949336399712 1548 704594 SGTC_1145 3546-0597 10.2 µM 0.525017073931356 0.336164884195832 no 1134 0.2997856608825 1438 875334 SGTC_1435 4092-0789 56.7 µM 0.524888194106069 0.336204150401226 no 1135 0.299830458466775 1514 2248285 SGTC_3097 9117246 49.47 µM 0.524183068272407 0.336419014844151 no 1136 0.300075608134312 1429 16423892 SGTC_115 0527-0192 112.043 µM 0.522594120697284 0.336903391345575 no 1137 0.300628366389077 1461 4233931 SGTC_1609 st001574 46.4 µM 0.522550828651468 0.336916592330201 no 1138 0.300643433124924 1415 3960012 SGTC_2796 7949634 45.45 µM 0.522496707599381 0.336933095671517 no 1139 0.300662269110481 1417 2971588 SGTC_2952 9073731 13.78 µM 0.522408044093684 0.336960132854939 no 1140 0.300693128207733 1415 16457353 SGTC_59 0330-0160 1.33 µM 0.521765888187924 0.337155977984744 no 1141 0.300916671516888 1428 4293482 SGTC_662 k832-1615 104 µM 0.520759020234014 0.337463142084669 no 1142 0.301267326897264 1489 5878478 SGTC_2296 7971656 126.45 µM 0.520252539797162 0.337617694483223 no 1143 0.301443785097815 1438 666570 SGTC_2605 digitonin 300 nM 0.520225193917586 0.337626039852214 no 1144 0.301453313748195 1504 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1011 4112-3381 17.4 µM 0.518547041915895 0.338138328088475 no 1145 0.302038323712056 1494 2877139 SGTC_2515 chrysin 20.77 µM 0.517318485195333 0.338513558875654 no 1146 0.302466926080263 1516 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_1042 0350-0096 82 µM 0.516530249730747 0.338754389441619 no 1147 0.302742058609241 1420 3122515 SGTC_8 0354-0001 70 µM 0.514835723612098 0.339272343255092 no 1148 0.303333909844969 1495 4993152 SGTC_1352 1496-0991 99 µM 0.514117739616051 0.339491896049547 no 1149 0.303584837727308 1461 3000039 SGTC_2458 5808907 16.39 µM 0.512511729918594 0.339983195962329 no 1150 0.304146456518322 1477 2731747 SGTC_317 4495-0002 170 µM 0.510002667282773 0.340751295823693 no 1151 0.305024796570662 1428 15991618 SGTC_2655 perillic acid 100 µM 0.509944480009976 0.340769116556766 no 1152 0.305045179374457 1427 5702197 An apoptosis inducer. SGTC_913 3487-1245 167 µM 0.50894866579065 0.341074154789336 no 1153 0.305394103413131 1403 4016153 SGTC_1919 st067113 52.3 µM 0.508228976758044 0.341294674933298 no 1154 0.305646385883973 1455 1268243 SGTC_307 1501-1223 22.3 µM 0.507277313369691 0.341586357633694 no 1155 0.305980127203086 1450 2830329 SGTC_810 3825-7150 143 µM 0.507196274352171 0.341611200285735 no 1156 0.306008554436836 1619 22330411 YGL099W LSG1 SGTC_539 4859-0462 2.54 µM 0.5063369860612 0.341874658797752 no 1157 0.306310051330499 1554 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_522 1273-0010 11.6 µM 0.506301110902128 0.341885659827521 no 1158 0.306322641635651 1509 5705015 SGTC_2343 7990716 14.84 µM 0.505010045183313 0.342281651261014 no 1159 0.306775890311516 1508 6456862 SGTC_1763 st044482 94.5 µM 0.504625726520018 0.342399561744018 no 1160 0.30691086846969 1521 88505 SGTC_276 colchicine 750 µM 0.504339855017298 0.34248727821404 no 1161 0.307011287570858 1510 2833 A microtubule depolymerizer. SGTC_1199 1638-0010 4.46 µM 0.504246904058019 0.342515801005796 no 1162 0.307043941905073 1448 3111136 SGTC_89 0302-0250 142.109 µM 0.503331544247137 0.342796734889455 no 1163 0.307365596046542 1538 4203518 YLR208W SEC13 SGTC_1756 st041558 35.5 µM 0.503087754173291 0.342871571384764 no 1164 0.30745128800532 1650 3955792 SGTC_3210 9128157 49.47 µM 0.501125674504555 0.34347409731764 no 1165 0.308141339355737 1443 17590849 SGTC_1478 0453-0656 35.7 µM 0.501060220062255 0.343494204286176 no 1166 0.308164370991966 1503 5258496 SGTC_2492 derrusnin 100 µM 0.499043642028719 0.344113894229449 no 1167 0.308874319670686 1423 1715307 Part of coumarin class of compounds. SGTC_1115 galangin 695.678 nM 0.498252554703456 0.344357108087802 no 1168 0.3091530221539 1514 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_1722 st034304 3.6505 µM 0.496407593276379 0.34492457762338 no 1169 0.309803434414113 1459 4036148 YLR033W RSC58 SGTC_477 mead ethanolamide 10 µM 0.493917149021821 0.345691136820009 no 1170 0.310682346409674 1424 16061185 SGTC_2947 9072639 7.68 µM 0.493269346444508 0.345890634455563 no 1171 0.310911142298691 1437 16488146 SGTC_2587 piperic acid 92.2 µM 0.490434563652109 0.346764138409208 no 1172 0.311913211795078 1455 5370536 SGTC_2876 9059903 25.97 µM 0.489543857933525 0.347038767107386 no 1173 0.312228356154924 1476 6916095 SGTC_2478 5763493 32.33 µM 0.489539525898432 0.347040102987622 no 1174 0.312229889226613 1534 1365576 YLR208W SEC13 SGTC_1693 xanthone 101.9 µM 0.489381567674997 0.347088814248781 no 1175 0.312285791566739 1524 7020 An insecticide. SGTC_623 k072-0108 16.9 µM 0.489313789995765 0.347109716348938 no 1176 0.312309779809302 1507 5382803 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.486031716574754 0.348122437371916 no 1177 0.31347233941489 1459 61125 An anti-inflammatory. SGTC_849 0386-0493 241 µM 0.483099329708081 0.349028175962566 no 1178 0.314512604989949 1471 726119 SGTC_1906 st060206 94.7 µM 0.482733333726314 0.349141283197832 no 1179 0.314642545889125 1565 5133468 SGTC_1384 3089-0840 101 µM 0.482420391238882 0.349238005434173 no 1180 0.314753669220391 1594 1069836 SGTC_976 1348-1067 47.6 µM 0.480122293445515 0.349948586252418 no 1181 0.315570218494538 1518 5310671 YGL099W LSG1 SGTC_1064 honokiol 6.76 µM 0.480000380080391 0.349986297049638 no 1182 0.315613561385293 1502 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2626 ethyl orsellinate 100 µM 0.479805104558574 0.350046703646133 no 1183 0.315682991426081 1473 75653 A natural product. SGTC_3041 9091929 49.47 µM 0.479530606632239 0.350131623344273 no 1184 0.315780599922696 1553 25236887 SGTC_2091 4-phenylthiadiazole 200 µM 0.474431684899099 0.351710403257183 no 1185 0.31759605145655 1533 270010 SGTC_44 0929-0055 61.211 µM 0.472578715631871 0.352284774281302 no 1186 0.318256885281783 1471 1379590 SGTC_1902 st060212 70.5 µM 0.468951820387959 0.353409989609993 no 1187 0.319552037263897 1496 688944 SGTC_652 0437-0092 114 µM 0.468867156535476 0.353436271249993 no 1188 0.319582296823419 1484 3091274 SGTC_886 0866-0150 153 µM 0.468057612737466 0.353687607850753 no 1189 0.319871695088483 1656 271463 SGTC_32 0928-0142 34.1 µM 0.463703425372817 0.355040531008298 no 1190 0.321430121363361 1545 2244242 SGTC_593 1203-0218 61.7 µM 0.463438534608955 0.35512289647279 no 1191 0.321525031448095 1629 3666956 SGTC_1875 nocodazole 6 µM 0.459888516500991 0.356227395468707 no 1192 0.3227981216216 1575 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_957 1187-1561 14.1 µM 0.459101206288628 0.356472511165901 no 1193 0.323080745234899 1516 1538454 SGTC_2734 clemastine 41.6 µM 0.458846541529167 0.356551809422126 no 1194 0.323172185047278 1562 26987 Clemastine is a selective histamine H1 antagonist. SGTC_673 1082-0474 110 µM 0.457978326758762 0.356822203263696 no 1195 0.323484006132178 1522 3098046 SGTC_1136 pergolide 1.05886 µM 0.457809677326395 0.356874735216711 no 1196 0.323544591305778 1550 47811 A dopamine receptor agonist. SGTC_1565 sinapyl alcohol 95.1 µM 0.45612470503149 0.357399729530188 no 1197 0.324150152890536 1465 5280507 A phenol propionate derived from cinnamic acid. SGTC_2333 9017922 200 µM 0.456084917262779 0.357412129649228 no 1198 0.324164457834562 1684 3163164 SGTC_3341 9147222 25.867 µM 0.455133808468398 0.357708593729586 no 1199 0.32450648834577 1552 1939759 SGTC_773 4358-1457 44.6 µM 0.453878987660179 0.358099857300987 no 1200 0.324957963996138 1695 1186886 SGTC_229 benomyl 22.8748 µM 0.452886012695425 0.358409580847118 no 1201 0.325315411689952 1531 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2767 sibutramine 71.45 µM 0.451437249836079 0.358861638457195 no 1202 0.325837220677985 1662 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_1142 3253-1408 9.78 µM 0.450877542608743 0.359036336948418 no 1203 0.326038905017001 1568 256655 SGTC_3178 9107506 49.47 µM 0.448708786036296 0.359713537767283 no 1204 0.326820872876521 1569 8897194 SGTC_209 4077-0173 175.592 µM 0.448551115743189 0.359762788004246 no 1205 0.326877752271566 1551 15993494 SGTC_2413 inermin 26.06 µM 0.448241658653859 0.359859457466356 no 1206 0.32698940029121 1682 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2512 diallyl trisulfide 49.23 µM 0.447395810662977 0.360123732622379 no 1207 0.327294650042148 1523 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_2447 5741742 33.78 µM 0.446997338913598 0.360248253563099 no 1208 0.327438490632734 1630 1776504 SGTC_2193 5925765 200 µM 0.446263014801084 0.360477765949759 no 1209 0.327703634531469 1606 877370 SGTC_157 1348-1695 65.819 µM 0.445649485813645 0.360669562477742 no 1210 0.327925229329046 1531 5380510 SGTC_253 dyclonine 31.25 µM 0.445302708897397 0.360777984614282 no 1211 0.328050505249297 1623 3180 An oral anasthetic. SGTC_1862 st057513 3.81 µM 0.445069400276084 0.360850936422619 no 1212 0.328134800732665 1544 5393163 SGTC_3226 9131256 49.47 µM 0.444849115239098 0.360919820615213 no 1213 0.328214398769133 1497 17178073 SGTC_825 1988-2224 89.6 µM 0.442666959997597 0.361602434455041 no 1214 0.329003322002319 1563 1180859 SGTC_1591 genipin 88.4 µM 0.442307952590859 0.361714780114798 no 1215 0.329133188490386 1630 442424 A DNA cross-linking agent. SGTC_882 0843-0131 351 µM 0.441275084659843 0.362038066162642 no 1216 0.329506930658298 1579 5425421 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.440368456096603 0.362321920635745 no 1217 0.329835133673757 1534 803109 SGTC_2541 muurolladie-3-one 83.07 µM 0.438566269322888 0.362886388299682 no 1218 0.330487921174922 1598 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_981 1488-1094 54.9 µM 0.436922533693511 0.3634014870025 no 1219 0.331083764674848 1535 3449522 SGTC_2124 5246320 200 µM 0.436204934952188 0.363626439011479 no 1220 0.331344023875266 1604 579342 SGTC_2606 farnesol 9.78 µM 0.435331981209663 0.363900154914625 no 1221 0.331660737170813 1658 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3161 9100388 49.47 µM 0.432997139975834 0.364632588747174 no 1222 0.332508423797373 1641 25236368 SGTC_2253 7938677 135.83 µM 0.432459710519108 0.364801249114056 no 1223 0.332703664275531 1682 2301972 SGTC_2176 5809774 33.9695 µM 0.432325325559509 0.364843426956905 no 1224 0.332752491514632 1671 2870539 SGTC_264 promethazine 12.5 mM 0.430797803485308 0.365322967379544 no 1225 0.333307698415055 1577 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1089 terbinafine 2.25 µM 0.42997586095949 0.365581089925889 no 1226 0.333606600338356 1644 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1849 st056239 19.2 µM 0.429248487085025 0.365809564948885 no 1227 0.333871200206767 1475 5393181 SGTC_1546 5-methoxyflavanone 78.7 µM 0.42917740007281 0.365831896607528 no 1228 0.333897064263709 1662 147795 SGTC_1455 4262-0120 131 µM 0.428940569255799 0.365906299201763 no 1229 0.333983237676404 1656 1529587 SGTC_1488 4013-0813 75.9 µM 0.427903443294614 0.366232181295965 no 1230 0.334360710052548 1573 2910057 SGTC_153 4077-0274 519.67 µM 0.42657471399082 0.366649830963955 no 1231 0.33484455918356 1707 3121976 SGTC_3045 9092950 49.47 µM 0.425812026040601 0.366889632413774 no 1232 0.335122411579502 1705 44120432 SGTC_300 r073-0011 5.04 µM 0.425312469273732 0.367046729320401 no 1233 0.335304452424321 1614 2735780 SGTC_379 3970-0972 5.9 µM 0.424731523074111 0.367229448972009 no 1234 0.335516200608799 1612 2898042 YBL034C STU1 SGTC_2433 5607874 27.82 µM 0.4245469226395 0.367287515942576 no 1235 0.335583496279569 1534 2252428 SGTC_1807 st050092 58.9 µM 0.423054770082079 0.367756991153479 no 1236 0.336127650574929 1558 5008496 SGTC_982 1491-0518 27.5 µM 0.422743303971656 0.367855012537592 no 1237 0.336241278603159 1607 3091256 SGTC_1437 4092-1038 11.6 µM 0.422628971731219 0.367890996154409 no 1238 0.33628299266475 1566 3977136 SGTC_142 0335-0849 62.6745 µM 0.422562565199425 0.36791189671617 no 1239 0.336307221980555 1625 3889043 YPR107C YTH1 SGTC_2285 7945142 200 µM 0.422494953625336 0.367933176950555 no 1240 0.336331891670765 1597 2970608 SGTC_2135 5326629 150.42 µM 0.418207506849217 0.369283443843773 no 1241 0.337897703854326 1556 5020077 SGTC_2240 6690706 185.951 µM 0.418016600605458 0.369343604555313 no 1242 0.337967489968871 1516 805876 SGTC_3087 9117406 49.47 µM 0.417932141869578 0.369370221246663 no 1243 0.337998365786032 1591 42546093 SGTC_548 1436-0017 110 µM 0.416509026154191 0.369818802159804 no 1244 0.338518781947458 1723 9677137 SGTC_2822 7994718 71.43 µM 0.416124252518979 0.36994011727996 no 1245 0.338659542028821 1635 1018011 SGTC_2585 alliin 100 µM 0.415222642849101 0.370224436099597 no 1246 0.338989462265804 1706 87310 A garlic compound which reacts with lipids. SGTC_2184 6075246 200 µM 0.412076048269148 0.371217256241443 no 1247 0.340141841859729 1642 2267320 SGTC_732 3970-1727 52.7 µM 0.409942678421374 0.371890869881904 no 1248 0.340923998523272 1738 1275699 SGTC_2402 5553605 200 µM 0.409878046399522 0.371911283640238 no 1249 0.340947705234834 1680 6758546 SGTC_3147 9097027 49.47 µM 0.408657136003579 0.372296970756807 no 1250 0.341395647127489 1715 25236841 SGTC_2528 xanthyletin 44.79 µM 0.408278994843983 0.372416452026311 no 1251 0.341534429348003 1621 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1307 1187-1599 12.2 µM 0.407878102212648 0.372543135490114 no 1252 0.341681585024398 1600 1538471 SGTC_1372 2752-0194 270 µM 0.406505347816266 0.37297703503052 no 1253 0.342185664204747 1562 823334 SGTC_22 0964-0034 14.468 µM 0.406173670702157 0.373081895568282 no 1254 0.342307499185506 1591 138402 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.402744566750292 0.374166565049734 no 1255 0.34356807228215 1608 689007 SGTC_3307 9126885 69.2785 µM 0.402294563840903 0.374308980910735 no 1256 0.343733627454602 1557 24824909 SGTC_2630 antimycin a 100 µM 0.401711592922019 0.374493503675786 no 1257 0.343948145855695 1549 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_1856 st057054 55.7 µM 0.400465761387495 0.374887932316458 no 1258 0.344406748361402 1739 1266018 SGTC_2870 9038528 12.99 µM 0.400084191538411 0.375008763038017 no 1259 0.344547253682119 1599 6463316 SGTC_112 phenothiazine 287.218 µM 0.39973283328533 0.375120037583215 no 1260 0.34467665316947 1777 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2718 lomofungin 53.02 µM 0.399383091900831 0.375230810391586 no 1261 0.34480547524073 1727 5351222 A RNA synthesis inhibitor. SGTC_2424 5537928 59.2 µM 0.398955810303126 0.375366156303207 no 1262 0.34496288252448 1585 5382802 SGTC_1588 farnesol 29.9 µM 0.397665062580869 0.375775107253862 no 1263 0.345438547020582 1597 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2033 5192550 145 µM 0.397598537355213 0.375796188400034 no 1264 0.345463069424648 1599 182073 SGTC_3110 9122132 49.47 µM 0.397218161432559 0.375916732658319 no 1265 0.345603295339212 1720 918317 SGTC_2073 5212005 126 µM 0.397054358760792 0.375968646803104 no 1266 0.345663687864499 1671 691789 SGTC_1759 st043059 70 µM 0.395660513415371 0.376410490337843 no 1267 0.346177744493289 1579 669426 SGTC_3148 9097893 49.47 µM 0.395374572290327 0.376501152602304 no 1268 0.346283235988306 1486 17174100 SGTC_278 4092-0821 23.9 µM 0.393068368366998 0.377232620576089 no 1269 0.347134493025512 1686 877900 SGTC_2656 pseudo-anisatin 100 µM 0.392486510674053 0.377417240445829 no 1270 0.34734938818961 1665 6708809 A neurotoxin. SGTC_1985 st071382 65.5 µM 0.392100234687041 0.377539818918309 no 1271 0.347492077059182 1643 6123237 SGTC_2988 9073640 71.4286 µM 0.391382947914031 0.37776747105381 no 1272 0.347757097361207 1671 9102229 SGTC_1002 4049-0206 172 µM 0.391250379998188 0.37780955004742 no 1273 0.347806086185034 1596 4662749 SGTC_3272 9137413 49.47 µM 0.391021737054427 0.377882128065533 no 1274 0.347890584310138 1539 17614870 SGTC_1789 tunicamycin 25 nM 0.389803227329875 0.378268991659146 no 1275 0.348341028558796 1648 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_3331 9141060 1.957 µM 0.388762457518269 0.378599521438088 no 1276 0.348725937497931 1592 4906567 YPR165W RHO1 SGTC_2765 myclobutanil 7.74 µM 0.388497458841155 0.378683694450735 no 1277 0.348823967117751 1627 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_3262 9137218 49.47 µM 0.386454894374736 0.379332678493557 no 1278 0.349579900923703 1628 17650664 SGTC_2525 harmine 47.85 µM 0.384997928887292 0.379795808150665 no 1279 0.350119474998361 1718 5280953 A monoamine oxidase inhibitor SGTC_2109 5483026 200 µM 0.384324257822152 0.380010008189856 no 1280 0.350369065437288 1673 759335 SGTC_271 rotenone 740 µM 0.383620237539763 0.380233897385455 no 1281 0.350629969110657 1707 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_3188 9110789 49.47 µM 0.380896284402174 0.381100533489358 no 1282 0.351640104830975 1734 849217 SGTC_305 1682-2595 20.8 µM 0.380252790089789 0.381305350956478 no 1283 0.351878888060582 1675 226033 SGTC_2972 9093619 59.92 µM 0.379990218669769 0.381388934230724 no 1284 0.351976337961245 1593 25236256 SGTC_1686 st019653 115.5 µM 0.377163900180856 0.382288974028216 no 1285 0.353025903036332 1760 97252 SGTC_3355 9151058 44.0485 µM 0.375385741247492 0.382855554358714 no 1286 0.353686803857037 1661 17015728 SGTC_510 ag-490 170 µM 0.37385314034752 0.383344093030091 no 1287 0.354256790556172 1768 5328779 SGTC_3280 9140961 49.47 µM 0.371792875065757 0.384001124611911 no 1288 0.355023534456724 1657 4901226 SGTC_298 1391-0729 10 µM 0.371400883637737 0.384126170973208 no 1289 0.35516948375848 1665 3237558 SGTC_2659 sanguinarine 24.21 µM 0.37134105645474 0.384145257073166 no 1290 0.355191760950837 1675 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3019 9081971 49.47 µM 0.370450671285291 0.384429341407637 no 1291 0.355523362372706 1771 16451803 SGTC_747 3448-8087 38.7 µM 0.370248158323731 0.384493963419293 no 1292 0.355598798478192 1626 5168703 SGTC_2937 9044753 11.33 µM 0.370079250304269 0.384547864528352 no 1293 0.355661721064685 1633 6465530 YGL099W LSG1 SGTC_290 2043-6722 48.1 µM 0.368400549859521 0.385083684453101 no 1294 0.356287293759413 1693 773758 YLR208W SEC13 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.367185515380461 0.385471645066928 no 1295 0.356740321467506 1906 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_3027 9089541 49.47 µM 0.365218737787734 0.386099880116886 no 1296 0.357474066111188 1666 9943819 SGTC_1784 st039334 36.3 µM 0.364331923740492 0.386383247226748 no 1297 0.357805081953238 1779 3496984 SGTC_872 0588-0139 234 µM 0.364032104256742 0.386479063417779 no 1298 0.357917018007774 1671 2047100 SGTC_1068 loratadine 26.9 µM 0.362709010073569 0.386901979928009 no 1299 0.358411134188531 1658 3957 A H1 histamine antagonist. SGTC_2724 maprotiline 69.64 µM 0.362528398289613 0.386959721475668 no 1300 0.358478602983287 1736 4011 A tricyclic antidepressant. SGTC_3194 9111903 49.47 µM 0.361554070630142 0.387271256936647 no 1301 0.358842646043453 1722 17087251 SGTC_812 4251-0442 148 µM 0.361073422876529 0.387424967950702 no 1302 0.359022280201524 1787 5723007 SGTC_1717 st033143 58.0435 µM 0.359920636289742 0.387793700657173 no 1303 0.359453242138849 1804 674616 SGTC_3220 9131269 49.47 µM 0.359362832493332 0.387972157290754 no 1304 0.359661837780322 1682 17722206 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.359000361771553 0.38808813423726 no 1305 0.359797409318183 1789 688798 SGTC_3325 9138760 55.175 µM 0.358097797400433 0.388376964112483 no 1306 0.360135063664767 1627 43844959 SGTC_3072 9116419 49.47 µM 0.357847790895517 0.388456979689233 no 1307 0.360228611802048 1647 17170162 SGTC_749 1000-0129 128 µM 0.355209833649976 0.389301556274404 no 1308 0.361216199146268 1825 708470 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.352635072430024 0.390126404466022 no 1309 0.362181020301185 1653 16623 A steroid. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.349582985326161 0.391104809198057 no 1310 0.363325840970865 1689 6708784 An antioxidant flavonoid SGTC_1954 st077032 68.9 µM 0.348178194875174 0.391555373690169 no 1311 0.363853181226697 1620 698907 SGTC_3302 9125395 16.351 µM 0.348019423486042 0.391606306285828 no 1312 0.363912798207053 1718 17599668 SGTC_140 0062-0056 502.533 µM 0.344721338705848 0.392664724545165 no 1313 0.365151937199925 1621 3758964 SGTC_2075 5212009 200 µM 0.344701399619867 0.392671125801068 no 1314 0.365159432906709 1792 780898 SGTC_3248 9135562 49.47 µM 0.343296225829038 0.393122316643489 no 1315 0.365687809921118 1729 17650701 SGTC_124 0136-0217 7.121 µM 0.342721555131418 0.393306880535058 no 1316 0.365903972559997 1860 3976905 SGTC_591 4299-0174 154 µM 0.342321144148418 0.393435492550826 no 1317 0.366054612502183 1752 5509088 SGTC_483 fpl-64176 144 µM 0.342063519555868 0.393518247723893 no 1318 0.366151545221835 1741 3423 SGTC_2282 7944268 200 µM 0.342029502682758 0.393529175115696 no 1319 0.366164344902574 1777 2970414 SGTC_495 decylubiquinone 155 µM 0.341536364551261 0.393687597491742 no 1320 0.366349916910828 1690 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1772 st048439 82.2 µM 0.340365409869205 0.394063841303216 no 1321 0.366790682118694 1711 2927068 YDL195W SEC31 SGTC_2275 7947463 200 µM 0.340083135204673 0.394154554833044 no 1322 0.3668969609124 1813 1225414 SGTC_2726 cimetidine 79.27 µM 0.339718830203885 0.394271638625389 no 1323 0.367034139900268 1752 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2735 sertaconazole 140 nM 0.339261955426508 0.394418486872739 no 1324 0.367206200018255 1806 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1570 verbenone 133 µM 0.339173536590297 0.394446908103019 no 1325 0.367239501841686 1865 29025 A natural terpanoid with antifungal properties. SGTC_362 0310-0100 9.03 µM 0.33802438025897 0.394816342406804 no 1326 0.367672407626783 1698 790235 SGTC_648 0375-0473 33.3 µM 0.337727964755098 0.394911650333187 no 1327 0.367784099450957 1743 1713139 SGTC_847 0342-0274 5.54 µM 0.337043531041011 0.395131743668249 no 1328 0.368042042463693 1831 18097 SGTC_1613 st002381 52.1 µM 0.336569703173949 0.395284132091289 no 1329 0.368220649169798 1717 551167 SGTC_250 brefeldin a 552.239 µM 0.334434391112113 0.395971071090862 no 1330 0.369025895769995 1715 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1240 0356-0016 42.1 µM 0.33245878292001 0.396606920582166 no 1331 0.369771428908317 1756 4305613 SGTC_2080 5212524 12.4 µM 0.328618005279103 0.397843860596173 no 1332 0.371222218509944 1879 260183 SGTC_671 0560-0003 407 µM 0.328583891400232 0.397854851749391 no 1333 0.371235112695551 1804 3238678 SGTC_1373 2887-0003 58.5 µM 0.328127673795026 0.398001848322767 no 1334 0.37140756532712 1724 776948 SGTC_3152 9099253 49.47 µM 0.328095415681745 0.398012242665784 no 1335 0.371419760039668 1799 25236131 SGTC_2795 7780010 54.55 µM 0.327520095406594 0.398197636901498 no 1336 0.371637273204831 1745 953673 SGTC_1629 st005085 44.9 µM 0.326477714744389 0.398533597656876 no 1337 0.372031473742559 1659 24207091 SGTC_1344 1488-0097 29.1 µM 0.326077724450002 0.398662535073444 no 1338 0.372182775035828 1772 747966 SGTC_318 1488-0629 67.2 µM 0.324394491779212 0.399205248480353 no 1339 0.372819694699224 1708 3662576 SGTC_3098 9119039 49.47 µM 0.323759701759683 0.399409970224686 no 1340 0.37305998378817 1738 17161528 SGTC_2051 5263410 176 µM 0.321445241190255 0.400156624817983 no 1341 0.373936501589336 1809 227584 SGTC_2334 9017922 200 µM 0.320975516023583 0.400308204765146 no 1342 0.3741144726892 1864 3163164 SGTC_2397 5161689 200 µM 0.320190390749417 0.400561597601012 no 1343 0.37441200356944 1808 2259942 SGTC_3120 9124077 49.47 µM 0.31974001020569 0.400706973178824 no 1344 0.374582713443487 1775 18774327 YGL155W CDC43 SGTC_1987 st072290 61.9 µM 0.31868160399648 0.401048663742838 no 1345 0.374983982888586 1757 54697379 SGTC_2893 9048488 25.97 µM 0.318584862623463 0.401079899023493 no 1346 0.375020666828615 1669 6467338 SGTC_1418 3966-3099 2.4 µM 0.318452679661356 0.401122578496354 no 1347 0.375070791904613 1818 740335 SGTC_1636 st007707 68.9 µM 0.31726971876566 0.401504587516095 no 1348 0.37551947612799 1873 403051 SGTC_2024 5144227 134 µM 0.315668145481545 0.402021927390873 no 1349 0.376127203758705 1817 3475211 SGTC_2800 7887935 81.82 µM 0.313198915023236 0.40281987385758 no 1350 0.377064771339222 1793 2961002 SGTC_466 geldanamycin 89.2 µM 0.310135104110392 0.403810525169644 no 1351 0.378229109110465 1877 5288382 HSP90 inhibitor. SGTC_2039 Aminomethylbenzodioxan 200 µM 0.308998834762866 0.404178083288051 no 1352 0.378661206601616 1748 15053 SGTC_2205 7238770 200 µM 0.308753345960707 0.404257504636039 no 1353 0.378754580381705 1871 279867 SGTC_2008 4012253 172 µM 0.308501485050414 0.404338991610537 no 1354 0.378850385203487 1742 603940 SGTC_2132 5317594 122.667 µM 0.308035369133099 0.404489809506372 no 1355 0.379027709652493 1812 794577 SGTC_2576 guaiol 23.12 µM 0.308032643324975 0.404490691518972 no 1356 0.379028746706425 1920 227829 SGTC_2864 9034755 47.6 µM 0.307179723361546 0.404766701802002 no 1357 0.379353289165086 1914 4930451 SGTC_678 1218-2179 85.9 µM 0.307059404073313 0.404805641700283 no 1358 0.379399078408227 1802 6820081 YOR116C RPO31 SGTC_1920 st075728 45.7 µM 0.305770544355741 0.405222824790335 no 1359 0.379889678590056 1910 3400306 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.30408314303131 0.405769172126761 no 1360 0.380532274521852 1881 1241132 A phosphatase inhibitor. SGTC_2221 6807166 181.081 µM 0.30394887803379 0.405812652389947 no 1361 0.380583419486224 1832 674925 SGTC_2429 5902844 64.44 µM 0.303371002260311 0.405999804448009 no 1362 0.380803570931102 1907 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1751 st044839 27.194 µM 0.303076398257137 0.406095223788072 no 1363 0.380915820114277 1841 5291326 SGTC_2099 5377090 177.372 µM 0.302600356038773 0.406249420969081 no 1364 0.381097221551613 1748 2243829 SGTC_2895 9054447 58.44 µM 0.298228625067533 0.407666166939596 no 1365 0.382764337811299 1778 2697450 SGTC_85 0868-0259 160.055 µM 0.297244436629251 0.407985279990793 no 1366 0.383139949283355 1802 83173 SGTC_3275 9138069 49.47 µM 0.295220032904052 0.408641863934471 no 1367 0.383912899792428 1831 17617007 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.291004597207755 0.410009896259118 no 1368 0.385523901766445 1795 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_2088 5278280 127.392 µM 0.290575199533543 0.410149310167175 no 1369 0.385688114960332 1812 791502 SGTC_2909 7941780 10.49 µM 0.290009382092268 0.410333033254812 no 1370 0.385904530019009 1949 1243215 SGTC_1850 st056238 17 µM 0.289288363020244 0.410567179419831 no 1371 0.386180358382643 1801 5393177 SGTC_905 2-aminofluorene 215 µM 0.288543654711971 0.410809051973073 no 1372 0.386465309550495 1774 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1395 3486-0190 4.35 µM 0.288370093458583 0.41086542751631 no 1373 0.386531728896137 1933 6748079 SGTC_2797 7859098 81.82 µM 0.286965526986382 0.411321721399459 no 1374 0.387069358030068 1772 972681 SGTC_2635 hydroquinidine 100 µM 0.284986018752777 0.411964997065013 no 1375 0.387827426697273 1789 442912 An experimental heart treatment. SGTC_1635 st007035 42.4 µM 0.282184996508587 0.412875641967118 no 1376 0.388900831047895 1793 3716403 SGTC_2775 cyproheptadine 69.59 µM 0.281425877353801 0.413122521423573 no 1377 0.389191886279007 1949 2913 A selective serotonin reuptake inhibitor. SGTC_2351 9026858 72.31 µM 0.279642469867813 0.41370265322725 no 1378 0.389875910114828 1740 1409300 SGTC_1991 st073000 8.92 µM 0.278402183148952 0.414106222247004 no 1379 0.390351821911096 1893 4301969 YIL048W NEO1 SGTC_1638 st008370 60.6 µM 0.278201802812466 0.414171431255318 no 1380 0.390428725512573 1807 24207134 SGTC_1961 st076550 68.7 µM 0.277987590853138 0.414241144052621 no 1381 0.390510942268429 1826 1579337 SGTC_1729 st035615 45.989 µM 0.277591592777928 0.414370024145375 no 1382 0.390662943296244 1784 17385451 SGTC_2274 7947094 46.08 µM 0.277551510763265 0.414383069606117 no 1383 0.390678329422411 1798 2971028 SGTC_181 1447-1644 8.07 µM 0.274608375610621 0.415341226576974 no 1384 0.391808565419041 1937 534600 SGTC_248 streptozotocin 5.23457 mM 0.274404605446394 0.415407583999853 no 1385 0.391886852083204 1939 5300 DNA alkylating agent. SGTC_2286 7945697 125 µM 0.273025032572649 0.415856903034848 no 1386 0.392416986563531 1749 1245733 SGTC_2332 7982454 138.89 µM 0.272804766415472 0.415928652669198 no 1387 0.392501647713147 1841 2981748 SGTC_848 0368-0089 85.6 µM 0.272006737867458 0.416188626434211 no 1388 0.392808419273216 1917 762535 SGTC_1672 st016598 6.51 µM 0.271010996069312 0.41651306066243 no 1389 0.39319128750256 1796 4665860 YNL267W PIK1 SGTC_2808 7946468 45.46 µM 0.270732193760414 0.416603910691176 no 1390 0.393298507064604 1863 2970879 SGTC_932 2857-0803 154 µM 0.266472899313097 0.417992387962933 no 1391 0.394937514154173 1943 674898 SGTC_2488 5268135 45.7 µM 0.266136087504417 0.418102228306137 no 1392 0.395067201531427 1910 1270356 YLR208W SEC13 SGTC_888 0916-0002 6.97 µM 0.26531836107681 0.418368930056393 no 1393 0.395382110561005 1906 2802138 YIL048W NEO1 SGTC_1641 st009299 47.1 µM 0.264970090878864 0.418482529903168 no 1394 0.395516251273361 1898 4046054 SGTC_528 3492-0019 172 µM 0.264046807297574 0.41878372226905 no 1395 0.395871925600206 1853 2869262 SGTC_2665 lovastatin 100 µM 0.263169233192983 0.419070047488613 no 1396 0.396210071765674 1844 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2192 5915882 198.485 µM 0.262706484438608 0.41922104533065 no 1397 0.396388409218755 1860 2876149 SGTC_2407 paclitaxel 400 µM 0.262591053681247 0.41925871297102 no 1398 0.396432898136786 1899 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_227 fluconazole 33.516 µM 0.26093823903225 0.419798144388362 no 1399 0.397070067793509 1816 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_455 paf C-16 10 µM 0.258923133675958 0.420456020946626 no 1400 0.397847274298459 1843 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_923 1900-2434 73.3 µM 0.256254488437057 0.421327602120217 no 1401 0.398877168556049 1807 5910570 SGTC_74 000s-0487 160.283 µM 0.254242347557539 0.421985023813682 no 1402 0.399654168268316 2004 677548 SGTC_3292 9120825 59.784 µM 0.254164022980681 0.422010619013233 no 1403 0.399684421810399 2005 24824900 SGTC_110 0850-0284 111.64 µM 0.253930569895112 0.422086909643532 no 1404 0.399774598646566 1952 3906265 SGTC_2646 retinol 96.75 µM 0.253248500790771 0.422309821195687 no 1405 0.400038094755539 1892 445354 A vitamin A analog and teratogen. SGTC_1325 1431-0015 227 µM 0.252563960158698 0.422533565506718 no 1406 0.400302591428072 1790 1103340 SGTC_467 ro 31-8220 72.8 µM 0.251353888274701 0.422929142506829 no 1407 0.400770257633415 1970 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_2199 6590217 200 µM 0.250687331493703 0.423147075621182 no 1408 0.401027927996343 1936 703109 SGTC_1761 st044296 37 µM 0.248867733140255 0.423742119325692 no 1409 0.401731547688662 1840 1826700 SGTC_3237 9133362 49.47 µM 0.248145557274871 0.42397833303157 no 1410 0.402010894024799 1947 43845137 SGTC_3017 9080681 49.47 µM 0.245505930531445 0.424841950080451 no 1411 0.403032358382282 1837 16451914 SGTC_852 0418-0143 439 µM 0.244978551579813 0.425014538107043 no 1412 0.403236519390995 1971 5369229 SGTC_447 ml7 120 µM 0.244862798542078 0.425052420929927 no 1413 0.403281333693207 1987 4216 Selective myosin light chain kinase inhibitor. SGTC_1795 st049545 62.3 µM 0.244198922765964 0.425269702783079 no 1414 0.403538380662074 2032 5291882 SGTC_1056 3448-1962 115 µM 0.24323230530425 0.425586110423837 no 1415 0.403912721084666 1901 715507 SGTC_3279 9140807 49.47 µM 0.242223071396263 0.425916519055167 no 1416 0.404303659435319 1956 45595718 SGTC_3112 9123419 49.47 µM 0.241860466514924 0.426035243379985 no 1417 0.404444141961604 1943 17015854 SGTC_1450 4112-4260 37.6 µM 0.241554542998483 0.426135414270491 no 1418 0.404562674241615 1983 1633175 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.241223783703917 0.42624372269279 no 1419 0.404690839178327 1858 5355888 SGTC_2163 5671233 125 µM 0.241198346809573 0.426252052333623 no 1420 0.404700696068604 1979 701023 SGTC_644 1498-1197 63.3 µM 0.240980638786044 0.42632334499382 no 1421 0.404785061202996 1930 6741615 SGTC_2181 6316240 54.2555 µM 0.239816152712469 0.426704719077017 no 1422 0.405236392137284 1817 12779990 SGTC_883 0850-0245 24.6 µM 0.236826950159109 0.427684008408836 no 1423 0.40639552150931 1960 6823229 YPR165W RHO1 SGTC_2371 9071574 200 µM 0.236825740914034 0.42768440465886 no 1424 0.406395990587583 1988 45596039 SGTC_1057 3448-5381 134 µM 0.236433236691015 0.427813025786988 no 1425 0.406548254000349 1978 5497911 SGTC_2404 5161160 200 µM 0.236235684403186 0.427877765313557 no 1426 0.406624895428992 1894 2831543 SGTC_1489 4065-0444 182 µM 0.234474922072232 0.428454867337727 no 1427 0.407308149936697 2004 2877968 SGTC_711 k292-0785 179 µM 0.233257059969059 0.428854119662826 no 1428 0.407780900067192 1899 4146315 SGTC_733 4069-0007 56.1 µM 0.231371761707441 0.429472321367176 no 1429 0.408513000457867 1931 5717425 YNL287W SEC21 SGTC_1781 st038725 66.3 µM 0.228653616809941 0.430363923105666 no 1430 0.409569074059396 1835 4270275 YIL048W NEO1 SGTC_2817 7995342 71.43 µM 0.228296860030408 0.430480972382718 no 1431 0.409707732722823 1837 18879975 SGTC_3232 9132874 49.47 µM 0.228211280603106 0.430509051272533 no 1432 0.409740996080637 1860 3784940 SGTC_789 1309-1135 70.6 µM 0.227782065526361 0.430649883439393 no 1433 0.409907834927178 1851 3092424 SGTC_3342 9147791 14.508 µM 0.22666047052091 0.431017937864208 no 1434 0.410343883537186 1916 1838168 SGTC_1671 st016596 74.5 µM 0.22528061112836 0.431470824611673 no 1435 0.410880491046615 1911 2829167 SGTC_331 k048-0133 24.5 µM 0.224580139879309 0.43170076236882 no 1436 0.41115295816271 1876 6813582 SGTC_3131 9127911 49.47 µM 0.224350993076302 0.431775987474281 no 1437 0.411242100280814 1934 45595681 SGTC_3170 9103054 49.47 µM 0.220756732885378 0.432956245681851 no 1438 0.412640927277443 1898 16432970 SGTC_1608 st001473 40.5 µM 0.217963081952805 0.43387401919084 no 1439 0.413728938095161 1847 7292267 SGTC_291 SEC14.278 35.5 µM 0.217439319901365 0.434046125964675 no 1440 0.413932995638721 2012 1068044 SGTC_2823 7987624 58.44 µM 0.216536149132639 0.434342934754531 no 1441 0.41428492526988 1929 2239440 SGTC_2728 chlorpromazine 9.18 µM 0.21573442254273 0.434606436986055 no 1442 0.414597383829066 1982 2726 A thorazine and dopamine antagonist. SGTC_589 1227-0070 34.1 µM 0.215668713500301 0.434628034764527 no 1443 0.414622995148817 1956 2841384 SGTC_1507 4075-3230 155 µM 0.214113627124251 0.435139229910344 no 1444 0.415229224652618 2058 659771 SGTC_2921 7974240 10.71 µM 0.213452120598136 0.435356716298833 no 1445 0.415487165359431 1965 2979074 YDR527W RBA50 SGTC_2085 5307070 144.047 µM 0.213432400924133 0.435363199922634 no 1446 0.415494855195648 1869 2840351 SGTC_1348 1493-0373 93.8 µM 0.212926110787191 0.435529668801389 no 1447 0.415692297943331 1966 3010129 SGTC_827 3253-0474 693 µM 0.212704713877629 0.435602467995515 no 1448 0.415778644879855 2042 5402065 SGTC_2383 9036125 200 µM 0.212609088797157 0.435633911877241 no 1449 0.415815940844013 1936 79580 SGTC_3315 9136395 68.55 µM 0.212376428847786 0.43571041789814 no 1450 0.415906686701189 2069 16876844 SGTC_1182 1222-0449 220 µM 0.207912406346613 0.437178793705289 no 1451 0.417648680991354 1972 658318 SGTC_21 0849-0113 22.993 µM 0.207831312645726 0.437205476376251 no 1452 0.417680341223874 1918 1560156 SGTC_2279 7948423 32.93 µM 0.207766965606364 0.43722664901163 no 1453 0.417705463680945 2070 1247112 SGTC_561 1550-0330 72.9 µM 0.207467417185124 0.437325214256815 no 1454 0.417822418195207 1899 6812934 SGTC_776 4476-4378 112 µM 0.207193263133384 0.437415426992679 no 1455 0.417929464201761 1894 2892008 SGTC_3316 9136639 10.545 µM 0.206710083727043 0.437574429227212 no 1456 0.418118140905151 1991 4903665 SGTC_364 0083-0097 67.7 µM 0.205144682275512 0.43808963272706 no 1457 0.418729543659305 1924 5207356 SGTC_1709 st033179 39.1045 µM 0.204678989950363 0.438242921256214 no 1458 0.418911468237826 1963 573381 SGTC_2090 5301565 104.445 µM 0.202631653872231 0.438916937478465 no 1459 0.419711473501565 1940 2056344 SGTC_428 3448-4153 16.5 µM 0.202160155738237 0.439072187476161 no 1460 0.419895760543255 1828 3834874 SGTC_499 genistein 192 µM 0.201632426893094 0.439245963652643 no 1461 0.420102046428752 2063 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_2981 9013952 38.96 µM 0.201535496652694 0.439277883148717 no 1462 0.420139938237785 1823 2996344 SGTC_1836 st055642 81 µM 0.201400932859457 0.439322196171055 no 1463 0.420192542919988 1855 8571 SGTC_3353 9151644 39.2805 µM 0.200279690282525 0.439691460572838 no 1464 0.420630922779705 1949 4909158 SGTC_1659 st012954 42.1 µM 0.199855182826228 0.439831279439417 no 1465 0.420796921078568 2010 24207262 SGTC_463 ikarugamyin 104 µM 0.19899749044262 0.440113798129282 no 1466 0.421132353836687 2045 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_3069 9117009 49.47 µM 0.19799025747725 0.44044561350585 no 1467 0.421526343127834 2075 41904981 SGTC_2337 9009472 200 µM 0.196940754070738 0.440791398635503 no 1468 0.421936950514684 2063 5742383 SGTC_1194 1488-0194 225 µM 0.196621528397048 0.44089658447988 no 1469 0.422061861122956 1959 1391452 SGTC_200 k038-0079 37.545 µM 0.19600017559008 0.44110133409745 no 1470 0.422305014280752 2000 3436683 SGTC_504 lovastatin 124 µM 0.194247608235886 0.441678928809893 no 1471 0.422991003373948 1889 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_1460 k062-0059 9.15 µM 0.192679299964235 0.442195902344965 no 1472 0.423605067951337 1928 1373085 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.192629493391706 0.442212322086851 no 1473 0.423624572555765 1924 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_2264 7948757 110.76 µM 0.192550366061451 0.442238408212448 no 1474 0.423655559760115 1870 2971411 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.19042439787485 0.442939375426393 no 1475 0.424488290352601 1928 75037 A free radical scavenger. SGTC_2619 obliquin 87.91 µM 0.190250945742755 0.442996573402206 no 1476 0.424556245569727 2027 6708593 A bioactive alkalod. YER133W GLC7 SGTC_1500 4488-1866 171 µM 0.187088624915427 0.444039594704095 no 1477 0.425795573347673 2071 2900003 SGTC_2877 9040724 71.43 µM 0.186442431016745 0.444252775355804 no 1478 0.426048910287404 2115 6463895 SGTC_990 3985-0011 41.3 µM 0.185573959284758 0.444539311301626 no 1479 0.426389438149479 1985 5399565 YGL099W LSG1 SGTC_2234 tolnaftate 200 µM 0.184499000496726 0.444894013903032 no 1480 0.426811005593408 2080 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_482 fipronil 114 µM 0.181333945246331 0.445938637809393 no 1481 0.428052731606082 2095 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1963 st076565 50.3 µM 0.181250294557855 0.445966251774383 no 1482 0.428085559471428 1973 4914280 SGTC_1905 st060207 84.5 µM 0.181098036760794 0.446016514334272 no 1483 0.428145312778886 1954 1948547 SGTC_3256 9138902 49.47 µM 0.180161538730407 0.446325685288646 no 1484 0.42851287598381 2063 17228773 SGTC_647 0140-0236 81 µM 0.17899153672569 0.446711989952781 no 1485 0.428972173547247 2018 990837 SGTC_735 3076-0345 636 µM 0.178985214183986 0.446714077631658 no 1486 0.428974655794606 2070 2888990 SGTC_2078 5212016 200 µM 0.176538496042181 0.447522084833702 no 1487 0.429935454053172 2140 1899708 SGTC_2445 5742597 35.57 µM 0.176038797765443 0.447687132702385 no 1488 0.430131731083817 1963 1774255 SGTC_1362 1611-0397 101 µM 0.174753176495817 0.448111808610811 no 1489 0.430636790906337 1990 27816 SGTC_1804 st050076 49.1 µM 0.174504057390357 0.448194106366868 no 1490 0.43073467117708 2045 3895976 SGTC_927 2425-1185 123 µM 0.173577685121013 0.448500157664163 no 1491 0.43109868523672 1929 730375 SGTC_1966 st070145 16.1 µM 0.172226269380585 0.448946688110144 no 1492 0.431629823231499 2029 3748532 SGTC_906 1165-0455 526 µM 0.171861759121546 0.449067139516642 no 1493 0.43177310549947 1987 3252859 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.170502893378509 0.449516214221914 no 1494 0.432307329547185 2080 229346 A bile salt which induces apoptosis. SGTC_426 0988-0037 14.6 µM 0.169941523129931 0.449701753429506 no 1495 0.43252806265647 2165 5383008 SGTC_1915 st067105 30.6 µM 0.168665562166498 0.450123513778672 no 1496 0.433029854021926 2069 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_2553 4-methylesculetin 85.09 µM 0.16757562448929 0.450483830012451 no 1497 0.433458574417752 1942 5319502 SGTC_1338 1486-1223 76 µM 0.167139553172841 0.450627999771301 no 1498 0.433630122394903 2070 3444526 SGTC_1315 1237-0019 3.69 µM 0.166966367084232 0.450685258720241 no 1499 0.433698256288517 2110 825140 SGTC_2842 9000675 19.48 µM 0.166217042808217 0.450933012835481 no 1500 0.433993073894723 1901 2989072 SGTC_1812 st052057 4.327 µM 0.166215202512642 0.450933621328333 no 1501 0.433993797994389 2045 3645418 SGTC_1666 st014829 29 µM 0.16574293342227 0.451089780685221 no 1502 0.434179628660559 2004 3858230 SGTC_1965 Pectolinarigenin 58.4 µM 0.164555932262635 0.451482304993522 no 1503 0.434646759605162 1991 5320438 An anti-inflammatory. SGTC_1879 gemcitabine 100 µM 0.164433365516154 0.451522838772556 no 1504 0.434694999577175 2057 60750 A nucleoside analog which inhibits DNA replication. SGTC_1038 k292-0204 154 µM 0.164278837007225 0.451573943275971 no 1505 0.43475582048478 1986 4454212 SGTC_3289 9119912 71.43 µM 0.16382676038509 0.451723455253255 no 1506 0.434933762276071 2031 17014829 SGTC_303 1348-1668 34.2 µM 0.163023647443765 0.451989079765981 no 1507 0.435249907885023 2039 5380509 SGTC_3348 9149464 3.537 µM 0.162044166079879 0.452313066096153 no 1508 0.435635536976081 2142 1951442 SGTC_1716 st033144 30.6155 µM 0.161120181176159 0.452618724788506 no 1509 0.435999372812217 2123 674617 SGTC_2935 9038016 29.96 µM 0.160190549196782 0.452926279898828 no 1510 0.436365486953152 2139 6463195 SGTC_2809 7964133 12.99 µM 0.158527494788313 0.453476547399292 no 1511 0.437020578440521 2015 1253665 SGTC_1374 2889-5571 141 µM 0.158452185902744 0.453501467547028 no 1512 0.437050247361965 1999 2853281 SGTC_1063 disulfiram 1.84 µM 0.158282843931708 0.453557504457622 no 1513 0.437116963141415 2109 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2912 7964298 10.93 µM 0.156546007287448 0.454132293830813 no 1514 0.437801328832323 2013 2975850 SGTC_1898 st060199 18.6 µM 0.156099802217761 0.454279976664396 no 1515 0.437977177129815 1978 688866 SGTC_2153 5569715 200 µM 0.155403273782247 0.454510522963289 no 1516 0.438251701708 2111 2054701 SGTC_1889 st059080 5.18 µM 0.154730634632422 0.454733176613794 no 1517 0.438516838946367 2181 176925 Isolated from Daphnopsis sellowiana. SGTC_1937 st074714 47.2 µM 0.154538994982374 0.454796614819609 no 1518 0.43859238347671 1976 17250970 SGTC_2348 9022543 33.42 µM 0.153854741318649 0.455023131750639 no 1519 0.438862135151542 2037 3162678 YDL140C RPO21 SGTC_1714 st033236 13.627 µM 0.153457427209326 0.455154666257527 no 1520 0.439018780377247 2089 2916566 SGTC_587 k089-0003 57 µM 0.152583117086028 0.455444131995707 no 1521 0.439363519849445 2156 9659696 SGTC_783 0848-0141 92.7 µM 0.151841635422899 0.455689639561709 no 1522 0.439655921266022 2128 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_2973 9094665 17.96 µM 0.150506152128236 0.456131866082666 no 1523 0.44018264866483 2123 25237061 YIL048W NEO1 SGTC_3074 9116018 49.47 µM 0.149487520510426 0.456469208189789 no 1524 0.440584477957571 2051 17027303 SGTC_2756 carbadox 75.1 µM 0.14861237387846 0.456759057178196 no 1525 0.440929754249923 2011 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_82 0054-0107 293.755 µM 0.148045192635288 0.45694692017769 no 1526 0.441153551306826 2147 3104697 SGTC_2440 5628896 157.78 µM 0.146171002080733 0.457567761833911 no 1527 0.441893198323874 2040 5522048 SGTC_1331 1472-0049 76.2 µM 0.144044148286806 0.458272425712262 no 1528 0.44273280391968 2009 24051409 SGTC_452 diindolylmethane 8 µM 0.143915975084718 0.458314895949482 no 1529 0.442783410359006 2093 3071 Inhibits expression of several cancer promoting factors. SGTC_665 3914-0008 307 µM 0.140737487722105 0.459368239901145 no 1530 0.444038664451999 2066 1069549 SGTC_2260 7964312 200 µM 0.14063969451645 0.459400652923275 no 1531 0.444077294094777 2158 231951 SGTC_2131 toluylene red 5.2905 µM 0.140421324535928 0.459473031430491 no 1532 0.444163555116462 2031 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.139740384113735 0.459698737052637 no 1533 0.444432558764647 2057 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_2211 7117706 200 µM 0.139376338109146 0.459819409667574 no 1534 0.444576384650099 2165 822771 SGTC_795 0685-0265 78 µM 0.138557092851182 0.460090983557771 no 1535 0.444900075555464 2196 302754 SGTC_1008 4106-0037 6 µM 0.138143586867565 0.460228064885499 no 1536 0.445063469322548 2097 2905394 SGTC_1457 k015-0032 57.3 µM 0.13803492443101 0.460264088344106 no 1537 0.445106408013633 2048 4302660 SGTC_433 pimozide 108 µM 0.13686185799407 0.460653000661953 no 1538 0.445569993992024 1956 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.135444095766751 0.461123088347037 no 1539 0.446130380971218 2092 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1923 st058458 19.1 µM 0.135399216936811 0.461137969719573 no 1540 0.446148121612839 2190 3534982 SGTC_3252 9135871 49.47 µM 0.134610030821308 0.461399664840362 no 1541 0.446460105174035 2138 17682838 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.134315321663288 0.461497395064932 no 1542 0.446576619044137 2042 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2607 solasodine 47.35 µM 0.133450156783556 0.461784310851994 no 1543 0.446918690360742 2050 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2701 st077767 14.721 µM 0.13302509065185 0.461925283397949 no 1544 0.447086768685247 2067 5721188 SGTC_1301 naphtanilide LB 4.81 µM 0.132032290153127 0.462254562799616 no 1545 0.44747937573403 2173 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.129827968483039 0.462985756246924 no 1546 0.448351267266117 2088 688664 SGTC_2195 6536160 144.242 µM 0.12622694883304 0.464180515004843 no 1547 0.449776139945218 2079 3834386 SGTC_573 3702-0553 84.7 µM 0.124869677198584 0.464630919698165 no 1548 0.450313362266194 2147 1222756 SGTC_2967 9089538 49.85 µM 0.119863951383393 0.466292435438663 no 1549 0.452295460584 2213 728216 SGTC_1335 1486-0900 202 µM 0.119449879561029 0.466429902129427 no 1550 0.452459472980568 2209 X1335 SGTC_1569 carminic acid 40.6 µM 0.119294231572704 0.466481576360625 no 1551 0.452521126702171 2193 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1231 0242-0792 125 µM 0.119131082587016 0.466535741486037 no 1552 0.452585752872543 2086 3707635 SGTC_170 4197-0004 226 µM 0.118862916342765 0.466624773469991 no 1553 0.45269198094647 2128 218692 SGTC_603 3794-0023 45.9 µM 0.118761512879108 0.466658440154376 no 1554 0.452732150548618 2204 3802260 SGTC_1766 st045414 44.774 µM 0.118746781235098 0.466663331186739 no 1555 0.452737986329167 2183 253960 SGTC_468 gf-109203x 121 µM 0.118537252481051 0.466732897077668 no 1556 0.452820989970779 2190 2396 A protein kinase C inhibitor. SGTC_2069 5228469 200 µM 0.117785970046701 0.466982339592379 no 1557 0.453118623219383 2098 2835210 SGTC_2493 resveratrol 26.09 µM 0.117346408333835 0.467128289898719 no 1558 0.453292775253636 2159 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2846 9008642 19.48 µM 0.114656280932641 0.468021604568012 no 1559 0.454358784038716 2062 2992898 SGTC_1366 1683-0113 21.9 µM 0.112170169908009 0.468847314513069 no 1560 0.455344240418648 2154 708623 SGTC_3203 9113543 49.47 µM 0.111922281456368 0.46892965290012 no 1561 0.4554425147767 2120 17018012 SGTC_1300 1094-0077 113 µM 0.111878000566302 0.468944361337503 no 1562 0.455460070040814 2107 5532636 SGTC_2537 larixol 68.93 µM 0.106598597754025 0.470698277456389 no 1563 0.457553715538727 2159 6708759 SGTC_2082 5219693 150 µM 0.10622851392265 0.470821247930466 no 1564 0.457700524049527 2188 2834649 SGTC_474 dl-dihydrosphingosine 5 µM 0.105870388234844 0.470940247633364 no 1565 0.457842594380925 2194 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1149 3909-7961 23.3 µM 0.104744675624167 0.471314321609628 no 1566 0.458289205449084 2058 735261 SGTC_189 3970-0742 2.116 µM 0.10426041124011 0.471475250330024 no 1567 0.458481346947587 2228 2891807 SGTC_949 1165-0505 146 µM 0.102775287212312 0.47196880948489 no 1568 0.459070659664602 2127 6244267 SGTC_1554 st069299 38.7 µM 0.102098974094732 0.472193586526321 no 1569 0.459339057657102 2152 24207999 SGTC_607 4491-0986 66.8 µM 0.0999187103095514 0.472918271240253 no 1570 0.460204431003796 2216 698981 YDR232W HEM1 SGTC_2223 6903751 107.57 µM 0.0992910691930046 0.473126905804623 no 1571 0.460453584564533 2195 5598863 SGTC_347 4534-1311 26.2 µM 0.0959020455907904 0.474253579126649 no 1572 0.461799184962169 2218 2862016 SGTC_1294 1000-1494 117 µM 0.0956645227997423 0.47433255087538 no 1573 0.461893509166166 2126 712797 YDL207W GLE1 SGTC_1299 1079-1439 3.74 µM 0.095101604527946 0.474519714369991 no 1574 0.462117061812717 2166 323161 SGTC_1475 4092-1048 11.7 µM 0.0943452089254118 0.474771215577082 no 1575 0.462417469258066 2136 2881759 SGTC_3141 9094609 49.47 µM 0.0943423033382511 0.47477218170299 no 1576 0.462418623272396 2061 25236309 YDL196W YDL196W SGTC_143 4032-1194 15.74 µM 0.0929391323664825 0.475238762057613 no 1577 0.462975958569061 2179 1806963 SGTC_2529 gangaleoidin 93.61 µM 0.092243982673337 0.475469924833509 no 1578 0.463252096932461 2192 4565183 SGTC_2883 9059145 45.46 µM 0.0921648292507874 0.475496246775484 no 1579 0.463283540633149 2205 16476510 SGTC_2321 7390090 138.78 µM 0.0912510092356332 0.475800139232749 no 1580 0.463646572236906 2113 649046 SGTC_123 0083-0120 66.675 µM 0.090194832860004 0.476151390074869 no 1581 0.464066195186578 2111 16001701 SGTC_169 k015-0017 16.025 µM 0.0900111271586829 0.476212486677882 no 1582 0.464139186264956 2221 1840002 SGTC_1141 3253-0389 52.6 µM 0.0892938645996311 0.476451038267206 no 1583 0.464424184966775 2234 5402031 SGTC_1074 carmofur 3.8 µM 0.0892808519741009 0.476455366164371 no 1584 0.464429355601395 2241 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1748 st037455 53.6035 µM 0.0873612941641835 0.477093826183879 no 1585 0.465192167246332 2187 580690 SGTC_17 0960-0276 49.807 µM 0.0864813217218661 0.477386531692405 no 1586 0.465541901772257 2268 6821114 SGTC_2247 cerulenin 830 nM 0.0860887096170042 0.477517130324809 no 1587 0.465697949361874 2236 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_1248 0469-0687 58.6 µM 0.0859024592667844 0.477579085553861 no 1588 0.465771978263741 2192 4017482 SGTC_2850 9015429 58.44 µM 0.0858700706993648 0.477589859500971 no 1589 0.46578485186428 2187 6457570 SGTC_2772 vinpocetine 57.06 µM 0.0847388499420929 0.47796616646986 no 1590 0.466234504620995 2222 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_974 1326-0144 138 µM 0.0845682931352381 0.478022904866696 no 1591 0.466302303575278 2148 5411856 SGTC_2089 5281248 129.67 µM 0.0832704480789764 0.478454667888472 no 1592 0.466818248841026 2212 2737878 SGTC_194 1486-1323 56.904 µM 0.0829052082792528 0.478576179300514 no 1593 0.466963456346419 2144 5178754 SGTC_1233 0325-0408 14.2 µM 0.0828252127520992 0.478602793231164 no 1594 0.46699526056267 2219 12874 SGTC_2532 xanthone 78.9 µM 0.0825345469997103 0.478699496417337 no 1595 0.467110823751732 2225 7020 An insecticide. SGTC_1610 st001799 48.1 µM 0.0791588924685039 0.479822651842328 no 1596 0.468453120502353 2121 621897 SGTC_3028 9087778 49.47 µM 0.0788750104250875 0.479917113146759 no 1597 0.468566020046779 2246 17217395 SGTC_75 0159-0059 199.013 µM 0.0783611121222652 0.480088114865741 no 1598 0.468770403202705 2257 5377270 SGTC_1568 digitonin 820 nM 0.0779945980755154 0.480210076123725 no 1599 0.468916175007781 2284 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_536 3852-0578 10.6 µM 0.077468638854178 0.480385097611021 no 1600 0.469125369423188 2252 2869208 SGTC_1908 st060353 56.5 µM 0.0766153969096348 0.480669035777008 no 1601 0.469464754997099 2280 4227716 SGTC_460 trequinsin 123 µM 0.0758572874159469 0.480921324410279 no 1602 0.469766319302712 2267 5537 A vasodilator. SGTC_109 0132-0036 33.701 µM 0.0754467876076502 0.481057936415709 no 1603 0.469929617066553 2268 67274 A color developer. SGTC_1202 1988-0068 29.6 µM 0.0754122655062469 0.481069425276674 no 1604 0.469943350268481 2170 2850480 SGTC_138 0850-0259 40.9225 µM 0.0752871694579142 0.481111057031199 no 1605 0.469993114899196 2289 6813004 SGTC_343 4130-2827 29.8 µM 0.0747582660058899 0.481287077482049 no 1606 0.470203523878229 2168 1118244 SGTC_1390 3413-2614 145 µM 0.0745406563127494 0.481359499617808 no 1607 0.470290096035429 2200 3421432 SGTC_2208 7283366 200 µM 0.0743818180601843 0.481412362566495 no 1608 0.470353287904113 2255 898663 SGTC_3050 9093513 49.47 µM 0.072850433358628 0.481922039239908 no 1609 0.470962568762743 2260 25236664 SGTC_583 1488-1091 88.9 µM 0.0712800570989602 0.482444723794204 no 1610 0.471587433490211 2292 4303273 SGTC_1479 0549-0158 134 µM 0.0694361736876369 0.483058481009322 no 1611 0.472321217976277 2273 5440202 SGTC_1414 3917-0015 5.4 µM 0.0665571338927756 0.484016881345667 no 1612 0.473467136116136 2282 6618702 SGTC_772 k072-0172 35.3 µM 0.0657467760748994 0.484286657347198 no 1613 0.473789715513582 2120 5861980 SGTC_2523 spermine 47.74 µM 0.0650694360473222 0.484512155956307 no 1614 0.474059357672011 2281 1103 A DNA binding polyamine. SGTC_1416 3966-0321 25.3 µM 0.0625965301606707 0.485335472066838 no 1615 0.475043896265694 2259 582530 YLR208W SEC13 SGTC_342 k048-0088 23.3 µM 0.0622345807187586 0.485455982914244 no 1616 0.475188012210725 2289 6820570 SGTC_1260 0700-1617 7.75 µM 0.0614805872279229 0.485707028843177 no 1617 0.47548823715201 2231 2853078 SGTC_1080 nisoldipine 24.4 µM 0.0612108120580946 0.485796853225421 no 1618 0.47559565955176 2299 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1081 sertraline 6 µM 0.0609506475461756 0.48588347832417 no 1619 0.475699256741696 2303 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2367 9070478 135.38 µM 0.0603028265263377 0.486099181496544 no 1620 0.475957225401263 2285 572802 SGTC_1417 3966-0327 90.4 µM 0.0601765347627438 0.486141232991306 no 1621 0.476007517192654 2245 651118 SGTC_2030 5175110 200 µM 0.059254009527079 0.486448411785669 no 1622 0.476374895896229 2246 2831986 SGTC_2465 5809242 33.21 µM 0.0591544077694157 0.4864815772681 no 1623 0.476414561670582 2313 2731748 SGTC_2137 5261020 140 µM 0.0589633095276811 0.486545209593296 no 1624 0.476490665999004 2299 763655 SGTC_1520 flindersine 88 µM 0.057487698440848 0.487036573327158 no 1625 0.477078352562711 2293 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_1409 3909-8004 61.9 µM 0.0565570858007382 0.487346468195683 no 1626 0.477449010181572 2242 2119279 SGTC_2705 st078069 42.8 µM 0.0565361074456813 0.487353454096051 no 1627 0.477457365964811 2259 1530061 SGTC_2669 eugenol 100 µM 0.0564923737154815 0.48736801766611 no 1628 0.477474785359095 2305 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_205 1486-1330 71.903 µM 0.0559998565766177 0.487532029711026 no 1629 0.477670960709405 2291 4118834 SGTC_1130 3454-2858 15.9 µM 0.0559699391107182 0.487541992528502 no 1630 0.4776828773616 2165 715628 YIL048W NEO1 SGTC_1648 st011736 69.8 µM 0.0546832078280039 0.487970494281268 no 1631 0.478195423777955 2283 2855514 SGTC_380 3970-0968 6 µM 0.0533988637389665 0.48839821490974 no 1632 0.47870705526394 2294 2891601 SGTC_1285 0929-0069 65.5 µM 0.0533575692090366 0.488411967306936 no 1633 0.478723505945255 2262 1206237 SGTC_2601 securinine 100 µM 0.0533340326347865 0.48841980574396 no 1634 0.478732882328827 2271 442872 A GABA receptor antagonist. SGTC_1013 4112-3890 241 µM 0.0522334370639296 0.48878634444794 no 1635 0.479171345182276 2191 705171 SGTC_2119 5528445 120.635 µM 0.051961083957182 0.488877049498483 no 1636 0.479279851002308 2275 791935 SGTC_992 3909-8734 162 µM 0.0508073352595394 0.489261302711767 no 1637 0.479739522868232 2289 4288319 SGTC_2830 7992007 71.43 µM 0.0499361499281798 0.489551455503358 no 1638 0.480086634874751 2316 1952075 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.0493455977652718 0.489748145117175 no 1639 0.480321940996624 2300 279621 SGTC_47 0149-0135 24.25 µM 0.0493006709714661 0.489763108561387 no 1640 0.480339842405926 2317 5239155 SGTC_1204 4049-0315 18.3 µM 0.0484956373834939 0.490031237732786 no 1641 0.480660620608262 2287 588402 SGTC_1710 st031758 61.5 µM 0.0477742270112444 0.490271518700295 no 1642 0.480948088480605 2309 5394341 SGTC_1945 st075991 56.6 µM 0.0475335957705183 0.490351666808963 no 1643 0.48104397751747 2185 1084980 SGTC_2423 st077119 87.2 µM 0.0462560156194338 0.49077720251185 no 1644 0.481553098104522 2312 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_372 0155-0182 15.9 µM 0.0454145707231188 0.491057476284738 no 1645 0.481888433606499 2264 771486 SGTC_3138 9097216 49.47 µM 0.0450717790637611 0.491171656766129 no 1646 0.482025047799681 2355 25237486 SGTC_2766 oltipraz 83.91 µM 0.0449167409289108 0.491223298660037 no 1647 0.482086836489929 2316 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1843 st055809 45.5 µM 0.0428674094891551 0.491905927155659 no 1648 0.482903614159047 2256 16413835 SGTC_1984 st072354 53.1 µM 0.0425614948075726 0.492007828849872 no 1649 0.48302554517544 2257 5762938 SGTC_1725 st036284 20.55 µM 0.0414592190450582 0.492375006638593 no 1650 0.483464901684853 2326 707914 SGTC_1980 st071811 45.7 µM 0.0399099948384115 0.492891077750656 no 1651 0.484082441362113 2301 4974850 SGTC_518 1021-0119 62.6 µM 0.0391251493113869 0.493152526817277 no 1652 0.484395305033028 2178 1097762 SGTC_2277 7947813 106.88 µM 0.0391095051986745 0.493157738240782 no 1653 0.484401541357899 2297 1246798 SGTC_2737 bleomycin 30.5 nM 0.0381012965718717 0.493493598774388 no 1654 0.484803458773733 2329 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1277 0873-0036 22 µM 0.0363489072162162 0.494077376113238 no 1655 0.485502076682092 2328 5965735 SGTC_3022 9087993 49.47 µM 0.0354187164914334 0.494387257837966 no 1656 0.485872930236396 2341 17173644 SGTC_2057 5236571 38.335 µM 0.0348658105962389 0.494571453328076 no 1657 0.486093371610032 2326 54684039 YBR257W POP4 SGTC_606 k015-0008 38.6 µM 0.0338636214574791 0.494905326302476 no 1658 0.486492951205553 2337 1970475 SGTC_1831 st055328 12 µM 0.0326924857315066 0.495295487269268 no 1659 0.486959908103692 2347 1103068 SGTC_600 1495-0418 41.6 µM 0.0318449406265631 0.495577847650287 no 1660 0.487297853678413 2334 5377768 SGTC_459 nigericin 15.3 µM 0.0317863002024715 0.4955973838416 no 1661 0.487321235985746 2308 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_568 1193-0097 7.48 µM 0.0317777696710156 0.495600225808533 no 1662 0.487324637457074 2354 3646150 SGTC_1121 fusaric acid 630.51 nM 0.031280093103514 0.495766028327615 no 1663 0.487523083020513 2302 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1703 st026983 48.3 µM 0.0306133499367758 0.495988157058982 no 1664 0.487788947715233 2352 1104023 SGTC_3351 9150312 21.596 µM 0.0299094070370186 0.496222680410957 no 1665 0.488069651738214 2350 4904905 SGTC_69 0096-0274 206.684 µM 0.0296286230163746 0.49631622588076 no 1666 0.488181618732095 2317 6741392 SGTC_2228 7354201 200 µM 0.029517420789974 0.4963532738591 no 1667 0.488225962606848 2300 753451 SGTC_950 1165-0508 94.1 µM 0.0278988806926462 0.496892507812833 no 1668 0.488871400587555 2316 6148369 SGTC_521 r062-0005 13.8 µM 0.0266032602022172 0.497324161782604 no 1669 0.489388086457947 2351 2832033 SGTC_1660 st012960 28.1 µM 0.026100305410397 0.497491729032222 no 1670 0.489588666732207 2324 24207266 SGTC_1837 st055472 66.5 µM 0.0260348733336234 0.497513528784403 no 1671 0.489614761486672 2320 676091 SGTC_2636 apigenin dimethyl ether 100 µM 0.0259406499040762 0.497544920853362 no 1672 0.489652338505288 2339 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_636 0kpi-0074 126 µM 0.0258812495175158 0.49756471106666 no 1673 0.489676027877368 2333 616434 SGTC_376 3970-0862 59.1 µM 0.0246612320178766 0.497971181167554 no 1674 0.490162589018193 2361 3135186 SGTC_2369 9071472 200 µM 0.0225581391895121 0.498671867916135 no 1675 0.491001367705063 2340 17296037 SGTC_1009 4106-0057 9.87 µM 0.0207111637188085 0.499287227579985 no 1676 0.491738031785522 2384 2928005 SGTC_565 1418-0001 44.5 µM 0.0192035891271591 0.499789509853451 no 1677 0.492339347211105 2366 2862145 SGTC_370 0180-0345 38.7 µM 0.0191419845441555 0.499810034813899 no 1678 0.492363919367202 2334 3989527 SGTC_1151 3909-8316 15.3 µM 0.0180016437311574 0.499810034813899 no 1679 0.492818771058203 2308 800431 SGTC_1388 3346-4487 254 µM 0.0174032742455979 0.499610674512944 no 1680 0.493057448540781 2348 3345614 SGTC_11 0438-0307 1.3 µM 0.0172470593698154 0.499558628014864 no 1681 0.49311975990706 2378 4011476 SGTC_2789 5281112 71.43 µM 0.0164514475259974 0.499293552176496 no 1682 0.493437118050214 2366 765948 SGTC_1220 1838-0075 193 µM 0.0163056030835066 0.499244960876604 no 1683 0.493495293761115 2354 5529645 SGTC_3062 9077494 49.47 µM 0.0155139763383487 0.498981213141594 no 1684 0.493811067164778 2352 16459633 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.014376130916448 0.49860211590431 no 1685 0.494264951096284 2371 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2658 polymyxin b sulfate 77.05 µM 0.0140077827645582 0.498479393190726 no 1686 0.49441188594921 2372 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2226 7298446 200 µM 0.0134365004900857 0.49828905911634 no 1687 0.494639773143176 2385 3283010 SGTC_2156 5649887 115 µM 0.0133142726979816 0.498248336540719 no 1688 0.494688530615681 2364 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_3034 9090421 49.47 µM 0.0125024834955029 0.497977873599917 no 1689 0.495012360662019 2374 17173761 SGTC_1726 st035556 14.5795 µM 0.0124453501369312 0.497958838573473 no 1690 0.495035151801168 2364 5919439 SGTC_1102 cgs 12066b 26.1 µM 0.00897477781402077 0.496802564074256 no 1691 0.496419629737307 2355 6438352 A 5-HT1B full agonist. SGTC_797 k781-0471 270 µM 0.0068319608356304 0.496088664464184 no 1692 0.497274463167355 2357 23738129 SGTC_2126 5251174 33.877 µM 0.00505543446932818 0.495496807411358 no 1693 0.497983182035166 2391 790722 SGTC_2594 a-mangostin 100 µM 0.00410683001028693 0.495180779917676 no 1694 0.498361616475987 2396 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_171 k064-0041 9.68 µM 0.00373144801216189 0.495055722261579 no 1695 0.498511371075368 2388 53325 SGTC_351 caspofungin 25 nM 0.00337946964020716 0.494938461911307 no 1696 0.498651789241466 2390 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1284 0929-0043 16 µM 0.00301968060477694 0.494818599918183 no 1697 0.498795323564248 2396 1239883 SGTC_1624 st003710 6.25 µM 0.00291029912633092 0.494782160094996 no 1698 0.498838960268862 2391 24207033 SGTC_1367 1812-0510 76.9 µM 0.00271768144538881 0.494717990706007 no 1699 0.498915803301381 2401 1142582 YDR527W RBA50 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.00225381342092443 0.494563456506957 no 1700 0.499100859295481 2397 688761 SGTC_1652 st011932 78 µM 0.00188965118732934 0.494442139124647 no 1701 0.499246138694809 2401 1551076 SGTC_481 bay k-8644 50 µM 0.00145015941273709 0.494295727066864 no 1702 0.499421470299708 2402 2303 A calcium channel antagonist. SGTC_836 0330-0104 1.35 µM 0.000432812116111482 0.49395681150676 no 1703 0.499827332952804 2405 46494820 SGTC_3320 9137005 35.139 µM -2.59239983529148e-05 0.493803991156297 no 1704 0.499989657820981 2406 4908713 SGTC_3259 9138485 49.47 µM -0.000314849943127274 0.493707740721034 no 1705 0.49987439304778 2408 17646153 SGTC_1719 st032227 49.2 µM -0.000682367861890846 0.493585309325947 no 1706 0.49972777463023 2408 3125804 SGTC_2105 5350118 200 µM -0.00293877475337134 0.492833645248512 no 1707 0.498827600185856 2412 2133313 SGTC_887 0885-0007 9.62 µM -0.00455778007369648 0.492294330678441 no 1708 0.498181715119148 2422 5719458 SGTC_3278 9139605 49.47 µM -0.00575281070952779 0.491896257314334 no 1709 0.497704973235751 2420 7958859 SGTC_1512 0259-0544 12.2 µM -0.00575343521922572 0.491896049287704 no 1710 0.497704724096551 2420 18476 SGTC_2692 st077426 47.7 µM -0.00700384455620199 0.491479537528243 no 1711 0.497205893124802 2413 25238571 SGTC_2459 5811157 9.22 µM -0.00898080474725456 0.490821030576233 no 1712 0.496417225435715 2425 2870684 YBR192W RIM2 SGTC_105 0111-0055 734.78 µM -0.011502153217678 0.48998122951658 no 1713 0.495411405944174 2466 5179370 SGTC_710 3448-4187 58 µM -0.01411785721124 0.489110047867755 no 1714 0.49436797694046 2436 3946412 SGTC_2729 fluphenazine 10.66 µM -0.0143309459237113 0.489039079158523 no 1715 0.494282975443505 2437 3372 An atypical antipsychotic. SGTC_67 0335-0847 266 µM -0.0148126896189039 0.488878636803236 no 1716 0.494090807920338 2445 4552207 YOR254C SEC63 SGTC_2531 methyl deoxycholate 70.07 µM -0.0156619520006109 0.488595798565831 no 1717 0.493752040588396 2440 16667744 Haematoxylin. SGTC_2623 humulene 100 µM -0.0158711873327107 0.488526115732072 no 1718 0.493668578142409 2452 6187145 An anti-inflammatory. SGTC_1405 3909-7894 12 µM -0.018889378282002 0.487520990442652 no 1719 0.492464676466866 2458 7104060 SGTC_1257 0669-0121 16 µM -0.0191635573058 0.487429686508696 no 1720 0.492355314658849 2469 4307855 SGTC_2299 7976368 114.88 µM -0.0206718755373913 0.486927415690222 no 1721 0.491753702147303 2460 2979718 SGTC_1873 rapamycin 2 nM -0.0207905532229696 0.486887896823811 no 1722 0.491706366773881 2456 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_1157 4092-0394 27.6 µM -0.0224271313100449 0.486342940691815 no 1723 0.49105361906807 2477 3659885 SGTC_1699 st031318 29.054 µM -0.023256799292557 0.48606668328605 no 1724 0.490722715777186 2490 5340658 SGTC_519 k048-0011 62.8 µM -0.023967202369575 0.48583014323549 no 1725 0.490439384952835 2520 6836379 SGTC_1246 0422-0085 105 µM -0.0244014707183983 0.485685549102942 no 1726 0.490266187606234 2448 264295 SGTC_2566 crystal violet carbinol 226 nM -0.0257603462215794 0.485233109712901 no 1727 0.489724245237663 2530 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_1780 st038448 24.544 µM -0.0259971610018156 0.485154263848342 no 1728 0.489629801439691 2550 728868 YDL195W SEC31 SGTC_382 3229-0966 23.2 µM -0.0261248746701634 0.485111742694967 no 1729 0.489578868356854 2462 5722370 SGTC_954 1189-0853 2.85 µM -0.0267862109672509 0.484891559254508 no 1730 0.489315125663533 2444 2828194 SGTC_2040 5100729 123 µM -0.0273060057871257 0.484718503463868 no 1731 0.489107833365277 2468 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1521 st012942 49.4 µM -0.0274566274758754 0.484668357376208 no 1732 0.489047766526717 2524 24207259 SGTC_1386 3228-0095 33.8 µM -0.0291060136833537 0.484119247547398 no 1733 0.488390019802775 2473 870181 SGTC_2978 9011784 42.97 µM -0.0294609784006305 0.484001077419951 no 1734 0.488248470073842 2493 2994934 SGTC_3233 9132340 49.47 µM -0.0295372125500196 0.483975698744918 no 1735 0.488218070278225 2466 17682950 SGTC_2859 9028643 45.46 µM -0.0303758236525794 0.483696525822517 no 1736 0.487883662943459 2504 17151580 SGTC_1398 3558-0053 112 µM -0.0322412259188429 0.483075563857681 no 1737 0.48713983986315 2472 4532369 SGTC_509 pifithrin 175 µM -0.0323172518611308 0.483050256922902 no 1738 0.487109525697397 2463 4817 A p53 inhibitor. SGTC_2318 6029776 164 µM -0.0332541694824234 0.482738388581683 no 1739 0.486735950491153 2485 818325 SGTC_2093 5331342 194.4 µM -0.0345787061770032 0.482297512962164 no 1740 0.48620784067659 2462 33839 SGTC_643 k048-0106 28.4 µM -0.0346071528365208 0.482288044650159 no 1741 0.486196498889596 2531 6763920 SGTC_2391 6285546 200 µM -0.0347802096862258 0.482230443858126 no 1742 0.486127500732787 2473 846083 SGTC_176 1486-1328 72.834 µM -0.0348198317327787 0.482217255982326 no 1743 0.486111703391696 2506 22310231 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.04032974706333 0.480383521451837 no 1744 0.48391511916897 2508 94937 An inhibitor of serotonin biosynthesis. SGTC_356 1634-0012 32.5 µM -0.0415504263249923 0.479977326502406 no 1745 0.483428546571682 2477 735457 SGTC_2246 7293507 91.5585 µM -0.0418224766400517 0.479886801474936 no 1746 0.483320108459607 2490 887656 SGTC_821 1114-0266 29.2 µM -0.0427811922762335 0.479567796142695 no 1747 0.482937978325539 2517 3123235 SGTC_2761 levamisole 97.89 µM -0.044097302705124 0.479129891768143 no 1748 0.482413421412257 2496 26879 An alkaline phosphatase inhibitor. SGTC_359 0081-0058 15.9 µM -0.0443426663360149 0.479048255638477 no 1749 0.482315631142711 2550 3494159 SGTC_73 0327-0325 16.231 µM -0.0458880762932772 0.478534095099161 no 1750 0.481699728953141 2559 53298 SGTC_2298 7976326 193.81 µM -0.047871829582917 0.477874149458148 no 1751 0.48090919518884 2529 2235818 SGTC_1971 st069429 63.5 µM -0.048588521940334 0.477635738465417 no 1752 0.480623608663296 2494 1246522 YGL099W LSG1 SGTC_1232 0279-0259 161 µM -0.0490057443182175 0.477496951212314 no 1753 0.480457359068966 2504 1560000 SGTC_301 4119-0100 24.5 µM -0.0500942227083114 0.477134886386051 no 1754 0.480023651785421 2501 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1212 0520-0165 585 µM -0.0509336764275112 0.476855668485637 no 1755 0.47968918520887 2581 5403258 SGTC_491 tetrandrine 80.3 µM -0.051343883796493 0.47671923001913 no 1756 0.479525749992408 2515 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_1947 st076332 61.6 µM -0.0513527503526994 0.476716280957054 no 1757 0.47952221740842 2484 24208416 SGTC_2709 st078560 56 µM -0.0526830545167589 0.47627382950785 no 1758 0.47899222040531 2515 17250903 SGTC_1175 0741-0056 27.6 µM -0.0532686338088164 0.476079078471159 no 1759 0.47875893565013 2535 765927 SGTC_1189 1431-2119 7.28 µM -0.0533700161289634 0.476045361478128 no 1760 0.478718547407864 2494 3107275 SGTC_1934 st074720 32.6 µM -0.0535865052032447 0.47597336369433 no 1761 0.478632304175833 2496 17250992 SGTC_2965 9082772 38.63 µM -0.0543268628122026 0.475727148864758 no 1762 0.478337373861167 2522 16459634 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.0557344936556742 0.475259049933178 no 1763 0.477776660117743 2494 66535 A nucleotide analog. SGTC_2499 avocadenofuran 51.48 µM -0.0569040809731287 0.474870136849918 no 1764 0.477310801718174 2517 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_3068 9116768 49.47 µM -0.0571897456553897 0.474775150787793 no 1765 0.477197023286933 2556 41904888 SGTC_2673 kobusone 100 µM -0.0588325264766385 0.474228939466265 no 1766 0.4765427504696 2526 6710676 An epoxy ketone and protein crosslinker. SGTC_983 1491-0821 12.2 µM -0.0593337159014116 0.474062307636967 no 1767 0.476343153501926 2563 46495113 SGTC_1269 0831-0796 3.05 µM -0.0596254827131452 0.473965305208856 no 1768 0.476226961101071 2549 927758 SGTC_3211 9128781 49.47 µM -0.0620830419357559 0.473148313127269 no 1769 0.475248350760097 2633 17194361 SGTC_395 anisomycin 6.25 µM -0.0623687466576765 0.473053340584937 no 1770 0.47513459152194 2562 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_261 5-fluorouridine 15.376 µM -0.0638255346223025 0.472569106308996 no 1771 0.474554573009514 2549 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2054 5233173 129 µM -0.0647722145176365 0.472254452926334 no 1772 0.474177682291304 2586 6889 SGTC_378 3970-0959 8.33 µM -0.0658263998733686 0.471904087726721 no 1773 0.473758018877662 2602 6615653 SGTC_738 1315-0003 72.4 µM -0.0662786109248729 0.471753799158705 no 1774 0.473578005892057 2565 6251474 SGTC_1004 4084-0029 199 µM -0.0672516137178777 0.471430443467508 no 1775 0.473190698144592 2559 716894 YLR208W SEC13 SGTC_3245 9134821 49.47 µM -0.0682516245730207 0.471098131877456 no 1776 0.47279266613887 2524 17014901 SGTC_934 2950-0684 338 µM -0.0685828369093064 0.47098807179897 no 1777 0.472660840428707 2587 1121253 SGTC_497 capsazepine 133 µM -0.0689552074675778 0.470864337711024 no 1778 0.472512636924946 2532 2733484 A calcium channel blocker. SGTC_1490 4089-0339 670 nM -0.0689667467634912 0.470860503391915 no 1779 0.472508044345187 2529 742542 SGTC_657 3534-0529 86.7 µM -0.0693767668311699 0.470724262192301 no 1780 0.472344860867472 2592 1049549 SGTC_1223 0764-0573 147 µM -0.0705470098495848 0.47033543350847 no 1781 0.471879142638972 2545 1609797 SGTC_873 0591-4978 488 µM -0.0709462414374301 0.470202789997118 no 1782 0.47172027036249 2560 3305145 SGTC_924 2046-0044 21.3 µM -0.071238627765072 0.470105647603231 no 1783 0.471603919492879 2525 3623589 SGTC_2167 5876490 200 µM -0.0725652961183957 0.469664897925045 no 1784 0.471076021785595 2759 686534 SGTC_2911 7942208 15.64 µM -0.0737475327852517 0.469272163069079 no 1785 0.470605638020941 2588 1243384 SGTC_418 lividomycin a 100 µM -0.0748756306124363 0.468897440812369 no 1786 0.470156833035288 2544 72394 An antibiotic. SGTC_422 cantharidin 155 µM -0.0756789616439533 0.46863061369388 no 1787 0.469837257080131 2530 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1494 4358-1428 177 µM -0.0759677004458752 0.468534712279447 no 1788 0.469722397613195 2538 1564571 SGTC_411 enrofloxacin 100 µM -0.0777295490045937 0.467949573441181 no 1789 0.469021594251221 2594 71188 A bacterial gyrase inhibitor. SGTC_2567 aureobasidin a 60 nM -0.078375269587651 0.467735136303801 no 1790 0.468764772508416 2744 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_962 1254-0300 21.5 µM -0.078806724060675 0.467591859942889 no 1791 0.468593177828626 2528 7340576 SGTC_1913 st060213 96.1 µM -0.0796535651390047 0.467310655224331 no 1792 0.468256395848633 2589 688959 SGTC_1201 1889-3372 45.9 µM -0.0804259058839484 0.46705420354191 no 1793 0.467949261860877 2597 5392199 SGTC_2783 7738165 71.43 µM -0.0811521312926134 0.466813076687605 no 1794 0.467660483793805 2602 17201110 SGTC_1563 conessine 56.1 µM -0.0825630218991361 0.466344657009222 no 1795 0.467099502549254 2593 441082 An anti-amoebic, histamine inhibitor. SGTC_2583 asiatic acid 100 µM -0.0836793988113086 0.465974049714668 no 1796 0.466655668527234 2644 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_2758 dehydroepiandrosterone 69.35 µM -0.0846507653926451 0.465651605967701 no 1797 0.466269519462116 2624 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_986 1493-0483 84 µM -0.0856916414052017 0.465306113696454 no 1798 0.465855773440016 2546 40079 SGTC_3052 9092717 49.47 µM -0.0860281380218431 0.465194427799262 no 1799 0.465722024615609 2667 25237534 SGTC_2852 9023854 51.95 µM -0.0889598410122037 0.464221489266122 no 1800 0.464556912881089 2657 19798528 SGTC_228 caffeine 993.056 µM -0.0891696387077886 0.464151872248143 no 1801 0.464473547017752 2599 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_804 1595-0054 20.9 µM -0.0893682835269657 0.464085957092621 no 1802 0.464394614333336 2572 761523 Stimulates phospholipase C. SGTC_2703 st077852 53.4 µM -0.0917818790503235 0.463285147006385 no 1803 0.463435670853609 2678 6281836 SGTC_1181 1222-0449 220 µM -0.092782509026985 0.462953190081782 no 1804 0.463038173418684 2681 658318 SGTC_1696 st025591 34.7925 µM -0.0942335086238395 0.462471869854372 no 1805 0.462461833581963 2591 2787147 SGTC_664 1222-0054 14.9 µM -0.0943463233139095 0.462434449675039 no 1806 0.462417026655597 2601 6813991 SGTC_1272 0839-0021 27 µM -0.0947179656191366 0.46231117976932 no 1807 0.462269423816874 2656 5027250 SGTC_413 propylparaben 100 µM -0.0953192878972779 0.462111735065884 no 1808 0.462030611440038 2573 7175 A pharmaceutical preservative. SGTC_3308 9128332 17.569 µM -0.0958206114433563 0.461945464910623 no 1809 0.461831523558705 2667 17332805 YDL196W YDL196W SGTC_1378 2093-0007 380 nM -0.0967101030895409 0.461650470389384 no 1810 0.46147830816896 2648 3618014 SGTC_1322 1348-1070 12 µM -0.0972623440921979 0.461467333607762 no 1811 0.461259029618738 2566 6758089 SGTC_390 dec-rvkr-cmk 16.7 µM -0.0976973792884523 0.461323070923278 no 1812 0.461086298313877 2638 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2363 9053361 176 µM -0.0981121553474419 0.461185531141176 no 1813 0.460921617762403 2679 6469797 YMR079W SEC14 SGTC_1383 3049-0032 20.7 µM -0.0983295533394626 0.461113443798911 no 1814 0.460835305857624 2681 712864 SGTC_1085 doxorubicin 7.67 µM -0.100397571263907 0.460427770704235 no 1815 0.460014348938249 2597 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3301 9125354 19.7965 µM -0.100817456124406 0.460288567765157 no 1816 0.459847684730583 2584 41905162 SGTC_1986 st071812 45 µM -0.101437294139119 0.460083083966016 no 1817 0.459601666348941 2598 11838594 SGTC_3338 9144300 39.5675 µM -0.102850640349922 0.459614582556199 no 1818 0.45904075657583 2643 4901274 SGTC_1316 1272-0050 65.9 µM -0.105181121160853 0.458842188622466 no 1819 0.458116045375304 2603 7340392 SGTC_2438 5259590 200 µM -0.105473939679155 0.458745150370749 no 1820 0.457999873875649 2690 1201127 SGTC_2324 6149169 200 µM -0.105621932436592 0.458696107418157 no 1821 0.457941161260134 2659 2888231 SGTC_3078 9116413 49.47 µM -0.107991049427192 0.457911097710578 no 1822 0.457001396104849 2572 17177322 SGTC_2584 androsterone 48.74 µM -0.108732770668802 0.457665361100675 no 1823 0.456707224355043 2626 2754130 A steroid. SGTC_2055 5235184 200 µM -0.108893176446623 0.457612219848138 no 1824 0.456643609434012 2703 2836034 SGTC_2732 terfenadine 20 µM -0.11030260131902 0.457145320458265 no 1825 0.456084697150169 2600 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_270 tamoxifen 5.46 µM -0.110805169257678 0.456978849329979 no 1826 0.455885423061368 2627 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_1625 st003711 30.1 µM -0.111865111122367 0.456627777866642 no 1827 0.455465180107841 2711 24207034 YER133W GLC7 SGTC_508 roscovitine 141 µM -0.112999134979641 0.456252206629087 no 1828 0.45501562050421 2608 160355 A CDKinase inhibitor. SGTC_42 0133-0086 60.653 µM -0.113267885982617 0.456163206151673 no 1829 0.454909088315631 2607 162923 Model of phenazepam hydroxylation. SGTC_3270 9137563 49.47 µM -0.113456296690725 0.456100812745112 no 1830 0.454834404741181 2743 17015724 SGTC_1912 st060209 90.8 µM -0.113963472029725 0.455932863783007 no 1831 0.454633374918739 2671 688787 SGTC_840 0245-0196 390 µM -0.116309999103309 0.455155924250348 no 1832 0.453703430630252 2732 3827528 SGTC_1790 st045711 43.5 µM -0.116781316945413 0.45499989061241 no 1833 0.453516674676777 2620 585119 SGTC_729 4092-0585 94.1 µM -0.116856091886619 0.454975136392194 no 1834 0.4534870466436 2598 2169061 SGTC_1810 st050138 53 µM -0.118065105694887 0.454574917093865 no 1835 0.453008035825279 2597 3444541 SGTC_3296 9122258 64.045 µM -0.11842519953006 0.454455724286835 no 1836 0.452865379965597 2707 4730474 SGTC_2297 7971671 152.32 µM -0.118836751617612 0.454319503571071 no 1837 0.452702345699939 2708 909016 SGTC_1561 5-methoxyflavone 52.9 µM -0.119906330891525 0.45396550585892 no 1838 0.452278674668196 2599 94525 SGTC_2110 5483698 200 µM -0.119993867553842 0.453936535541792 no 1839 0.452244002920883 2666 2848765 YHR062C RPP1 SGTC_1529 apigenin 74 µM -0.120867230664851 0.453647508880042 no 1840 0.451898098989696 2777 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_1058 3448-5425 97.3 µM -0.124343741108336 0.452497253774426 no 1841 0.4505215578081 2608 7279705 SGTC_1448 4255-0083 152 µM -0.125070692959914 0.452256781020542 no 1842 0.450233792355812 2789 5399660 SGTC_595 3909-8003 73.7 µM -0.125333987054845 0.452169688706613 no 1843 0.450129573268712 2716 699517 SGTC_1678 st019265 80.2 µM -0.12684470214314 0.451670019596656 no 1844 0.449531657135937 2678 5367020 SGTC_1158 4092-0494 91.8 µM -0.127247743281403 0.451536726618749 no 1845 0.449372159400286 2764 1148199 SGTC_899 1083-0020 478 µM -0.127497131247829 0.451454252253015 no 1846 0.449273471793178 2812 767123 SGTC_2475 5812728 15.03 µM -0.127606221930638 0.451418175850601 no 1847 0.449230303501365 2616 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1337 1486-1011 40.3 µM -0.128466615135369 0.451133657007311 no 1848 0.448889858267001 2640 X1337 SGTC_2335 9018011 154.17 µM -0.130131720322657 0.450583103677655 no 1849 0.448231107152444 2748 6458208 SGTC_845 0330-0138 4.51 µM -0.130656307842667 0.450409672774786 no 1850 0.448023598625261 2632 9039800 SGTC_2801 7907800 81.82 µM -0.131577628211104 0.45010510321497 no 1851 0.447659190877585 2715 6620925 SGTC_1914 st062367 72.6 µM -0.134043418019052 0.449290108881503 no 1852 0.44668412079844 2676 978205 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.134697884247651 0.449073830086832 no 1853 0.446425373035585 2691 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_634 1611-4317 11.2 µM -0.135104062795132 0.44893960951828 no 1854 0.446264798993312 2628 2843522 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.135860158252928 0.44868977545617 no 1855 0.445965916236918 2794 688751 SGTC_2717 st081029 62.2815 µM -0.135935412202927 0.448664910659918 no 1856 0.445936170204574 2683 5292846 SGTC_3127 9126946 49.47 µM -0.136284190152717 0.448549672929466 no 1857 0.445798310850024 2752 27243249 SGTC_2353 9059630 146.67 µM -0.137215855048296 0.448241868163514 no 1858 0.445430089466521 2749 4779114 SGTC_316 k060-0003 58.6 µM -0.13881476725933 0.447713690008174 no 1859 0.444798262191261 2794 6152314 SGTC_469 w7 172 µM -0.13935348596263 0.447535752694224 no 1860 0.444585413231258 2641 45115570 A P450 inhibitor. SGTC_2919 7978188 46.38 µM -0.139747221908017 0.44740570946487 no 1861 0.444429857385311 2722 2980291 SGTC_2164 5685496 200 µM -0.140244113790891 0.447241603932043 no 1862 0.444233559264901 2658 759046 SGTC_1100 amiodarone 5.07 µM -0.140669792470686 0.447101024743179 no 1863 0.444065404937968 2719 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_254 nsc-64875 3.808 µM -0.140720210858994 0.447084374651864 no 1864 0.444045489008629 2807 56993 SGTC_2222 6885208 172.143 µM -0.141519681818688 0.446820371070578 no 1865 0.443729706336801 2685 609514 SGTC_296 1222-0039 74.9 µM -0.14216189524776 0.446608314582691 no 1866 0.443476064612308 2688 5984176 SGTC_1276 0871-0068 94.2 µM -0.142554133042171 0.446478806626174 no 1867 0.443321161965778 2758 3414906 SGTC_448 monastrol 171 µM -0.14520026516652 0.445605264106399 no 1868 0.442276378290237 2690 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_2582 agaric acid 100 µM -0.147986879550767 0.444685630974851 no 1869 0.441176561414781 2738 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_1208 2323-2347 50.3 µM -0.149506984088335 0.444184094151563 no 1870 0.440576799400316 2763 5412760 SGTC_1820 st053765 18.6 µM -0.149646050241198 0.444138215706559 no 1871 0.440521937197476 2736 3690829 SGTC_537 1334-0398 209 µM -0.151408676315314 0.443556783833658 no 1872 0.439826672828487 2667 5846986 SGTC_512 prima-1 270 µM -0.152902835079581 0.443064005512514 no 1873 0.439237450065892 2833 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2925 9010536 32.5 µM -0.153412275966937 0.442896010375345 no 1874 0.439036582329639 2772 2994177 SGTC_56 0957-0365 83.25 µM -0.154323826524379 0.442595439682822 no 1875 0.438677205751395 2657 6752360 SGTC_2155 5570423 76 µM -0.154847064715027 0.442422924324788 no 1876 0.43847094319198 2693 797402 SGTC_1705 st027868 56.3335 µM -0.156184008642674 0.4419821740529 no 1877 0.437943990650517 2762 292948 SGTC_605 1315-0399 119 µM -0.156200992412809 0.441976575474625 no 1878 0.437937297252913 2788 24020461 SGTC_1527 coumarin 137 µM -0.156270055035869 0.441953809594612 no 1879 0.437910079474695 2912 323 A hepatotoxic, DNA x-linker. SGTC_2380 9035439 200 µM -0.15665751460617 0.441826090547457 no 1880 0.437757385994978 2812 6462575 SGTC_3056 9094900 49.47 µM -0.156734941780999 0.441800568802754 no 1881 0.4377268739224 2734 25236784 SGTC_203 k066-0004 30.888 µM -0.157021347697513 0.441706165047858 no 1882 0.437614011883242 2642 6795412 SGTC_2076 5212012 200 µM -0.157780926010431 0.441455812509984 no 1883 0.437314714607632 2631 604802 SGTC_2451 5856223 45.7 µM -0.158200495162423 0.441317535010233 no 1884 0.437149406792284 2725 2179896 SGTC_2032 5185112 25.99 µM -0.16014132934767 0.440677987183537 no 1885 0.436384872579509 2772 5718189 SGTC_391 gliotoxin 8.33 µM -0.160587446765211 0.440531003425547 no 1886 0.43620917130033 2817 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1664 st014217 9.02 µM -0.16076959764415 0.440470991936958 no 1887 0.436137435636997 2694 3982782 SGTC_586 0957-0265 8.15 µM -0.163855941058536 0.439454373169731 no 1888 0.434922276078601 2686 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_3009 9080819 71.4286 µM -0.164155991680833 0.439355559889196 no 1889 0.434804172303728 2759 17027216 SGTC_844 0330-0132 15.3 µM -0.165285008696165 0.438983783619752 no 1890 0.434359828929587 2806 2828079 SGTC_2856 9022925 19.48 µM -0.167347525390813 0.438304752572858 no 1891 0.433548305744941 2848 4944862 SGTC_113 0099-0221 2.5 µM -0.169373477317452 0.437637936314018 no 1892 0.432751442060978 2747 89219 SGTC_166 k072-0058 166.424 µM -0.169890727038577 0.437467718459845 no 1893 0.432548036930192 2716 5846229 SGTC_1026 k007-1105 30.6 µM -0.170061572954592 0.437411498592109 no 1894 0.43248085679516 2706 7066794 SGTC_2108 5365811 200 µM -0.17080822867583 0.437165813176461 no 1895 0.432187279308482 2807 780283 SGTC_2958 9077254 16.72 µM -0.170861794921808 0.437148188251902 no 1896 0.432166219039126 2889 16457351 SGTC_2544 sphondin 68.51 µM -0.171172062407706 0.43704610326462 no 1897 0.432044237117407 2934 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1218 1348-1416 30.7 µM -0.171245706179688 0.437021873421113 no 1898 0.4320152849577 2696 6787668 SGTC_946 3434-1334 87.4 µM -0.173163327020449 0.43639103244331 no 1899 0.431261524462775 2848 4047976 SGTC_3283 9109332 35.8195 µM -0.17623601953547 0.435380544683279 no 1900 0.430054262064661 2681 17027281 SGTC_757 1066-0008 322 µM -0.176363518875876 0.435338624232173 no 1901 0.430004181557532 2874 6842497 SGTC_3225 9130819 49.47 µM -0.177704238601006 0.434897853679163 no 1902 0.429477628155814 2758 4547121 SGTC_2098 5376439 882.5 nM -0.179106290832018 0.434437006190062 no 1903 0.428927121256002 2811 2844116 SGTC_3304 9125678 46.087 µM -0.179494827908591 0.434309311751143 no 1904 0.428774589056832 2752 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_146 3448-8650 53.125 µM -0.18115199148645 0.43376475468262 no 1905 0.428124138152157 2764 2891488 YIL048W NEO1 SGTC_2041 5107442 45.335 µM -0.182294025738593 0.433389546284279 no 1906 0.427675993452217 2853 793005 SGTC_837 0091-0265 12.5 µM -0.184467714050582 0.432675560358512 no 1907 0.426823276478435 2736 759367 SGTC_2185 6113692 200 µM -0.185223085043226 0.432427496884216 no 1908 0.42652703155906 2858 874150 SGTC_137 0438-0332 85.389 µM -0.186337542790425 0.432061558150939 no 1909 0.426090034050201 2726 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_333 3486-0131 40.1 µM -0.186587533663003 0.431979480174573 no 1910 0.425992020892422 2881 6744690 SGTC_999 SEC7.066 22.7 µM -0.187863588064492 0.431560566842069 no 1911 0.425491793493239 2760 740511 YDR170C SEC7 SGTC_2373 9071805 200 µM -0.187913855418053 0.431544066246178 no 1912 0.425472090585759 2766 10149009 SGTC_1333 1482-0047 286 µM -0.189556430024807 0.4310049460058 no 1913 0.424828365948133 2775 3811116 SGTC_145 3737-0113 38.366 µM -0.191217049898716 0.430460033669987 no 1914 0.424177773094085 2864 6849351 SGTC_3288 9119690 36.221 µM -0.192708895372877 0.429970615471997 no 1915 0.423593478269622 2796 17595618 YKL019W RAM2 SGTC_1327 1436-0082 2.18 µM -0.19355619631204 0.429692695865531 no 1916 0.423261699868524 2779 15992205 SGTC_221 trifluoperazine 10.304 µM -0.193937416005067 0.429567664957396 no 1917 0.423112443058492 2760 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_3042 9091578 49.47 µM -0.194136059932377 0.429502517316517 no 1918 0.423034673486486 2737 25236497 SGTC_2220 6782180 200 µM -0.201641368561979 0.427042484185 no 1919 0.420098551003665 2773 833803 SGTC_1275 0867-0008 21.1 µM -0.202575038973975 0.426736649089642 no 1920 0.419733600744898 2767 3422836 SGTC_2904 7225135 42.03 µM -0.202829471364112 0.426653314295084 no 1921 0.419634160938014 2850 4446116 SGTC_1813 st051246 8.6015 µM -0.203655352927173 0.42638283409003 no 1922 0.419311417054749 2820 5291959 SGTC_534 k292-0788 63.4 µM -0.204560415271409 0.426086461560013 no 1923 0.418957792684104 2790 4146317 SGTC_3054 9094397 49.47 µM -0.204745212396591 0.426025952853223 no 1924 0.418885597114511 2810 2598354 SGTC_835 0312-0010 67.2 µM -0.206837978340994 0.425340833759045 no 1925 0.418068197507736 2762 1626196 SGTC_2225 6654152 15.4 µM -0.208094719771977 0.424929516306534 no 1926 0.417577504965395 2777 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_506 n9-isopropylolomoucine 153 µM -0.208141671402963 0.424914151142099 no 1927 0.417559175263126 2909 6610355 SGTC_1481 3346-2004 36 µM -0.20932397705931 0.424527273155662 no 1928 0.417097667686047 2794 2770522 SGTC_620 0109-0052 432 µM -0.210342024147118 0.424194202639475 no 1929 0.416700369168022 2886 493037 SGTC_1404 3909-7820 48.3 µM -0.210885895045936 0.424016288677109 no 1930 0.416488155372624 2854 23741373 SGTC_326 k292-0812 17.5 µM -0.211005354920043 0.423977212395962 no 1931 0.416441546404514 2836 3579357 SGTC_1637 st007924 17.4 µM -0.211062398506699 0.423958553245758 no 1932 0.41641929045266 2764 683336 SGTC_2621 lithochol-11-enic acid 100 µM -0.212459825449767 0.423501503504723 no 1933 0.415874158472055 2813 6708711 SGTC_2639 lactacystin 53 µM -0.212731019683103 0.423412817209281 no 1934 0.415768385148285 2929 3870 A proteasome inhibitor. SGTC_684 1140-0066 328 µM -0.214759469012928 0.422749594381268 no 1935 0.414977427288576 2848 6813534 SGTC_656 4090-1979 187 µM -0.215682644777933 0.422447824734034 no 1936 0.414617565144282 2905 22330961 SGTC_1280 0880-0253 10.1 µM -0.215748779303253 0.422426208285438 no 1937 0.414591788063317 2821 6836607 SGTC_2939 9044578 71.43 µM -0.217276773554239 0.421926839795743 no 1938 0.413996328376484 2774 2653634 SGTC_2955 9076254 12.21 µM -0.21727973587957 0.421925871790747 no 1939 0.413995174149211 2888 16459619 SGTC_1788 fluconazole 20 µM -0.217353048674553 0.421901915371862 no 1940 0.41396660911444 2885 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_1075 aripiprazole 15.2 µM -0.220031698990061 0.421026811803911 no 1941 0.412923233688948 2783 60795 An atypical antipschotic. YIL048W NEO1 SGTC_107 0358-0022 2.6945 µM -0.221152393513298 0.420660801188429 no 1942 0.412486887965113 2864 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_184 1494-0393 24.714 µM -0.221828368500893 0.420440065849593 no 1943 0.412223747354871 2762 3090647 SGTC_2695 st077686 51.995 µM -0.22260963582533 0.420184979136586 no 1944 0.411919668160208 2855 2876092 SGTC_1160 4092-0570 10.5 µM -0.223630806211096 0.419851613731722 no 1945 0.411522295395331 2802 4994975 SGTC_1497 4476-2978 41.3 µM -0.223974540221015 0.419739413229602 no 1946 0.411388556979 2879 1528379 SGTC_726 3448-4391 34.2 µM -0.22457566412709 0.41954321206756 no 1947 0.41115469926477 2977 1356692 SGTC_3300 9124615 50.48 µM -0.224857624662898 0.419451189701156 no 1948 0.411045017865194 2997 24824903 SGTC_1411 3909-8223 150 µM -0.225258447346778 0.419320382339846 no 1949 0.410889111587088 2909 X1411 SGTC_2427 5545055 42.75 µM -0.225317343814372 0.41930116239343 no 1950 0.410866204066546 2831 5372858 SGTC_1816 st051957 91.6 µM -0.225532422540431 0.419230976431281 no 1951 0.410782552730027 2841 674121 SGTC_764 1951-2361 146 µM -0.225950336408226 0.419094607267605 no 1952 0.410620023603144 2821 5438930 SGTC_329 k048-0121 21.3 µM -0.226058159821252 0.419059425066435 no 1953 0.410578092941926 2888 6832902 SGTC_663 1486-0733 13.9 µM -0.227628687118423 0.418547043948106 no 1954 0.409967458124735 2810 722445 YPR165W RHO1 SGTC_3291 9121177 71.43 µM -0.227809748381526 0.418487981970693 no 1955 0.409897073918931 2843 17015612 SGTC_190 3970-0790 3.722 µM -0.227945057122466 0.418443845613487 no 1956 0.409844477052314 2838 2832352 SGTC_694 1315-0438 43.2 µM -0.228544620161113 0.418248286512902 no 1957 0.409611435978524 2848 6793154 SGTC_2545 solidagenone 89.61 µM -0.230063442923118 0.417752983583966 no 1958 0.409021235648683 2751 6708572 An anti ulcer agent SGTC_2257 7960413 200 µM -0.231523113915063 0.417277093531655 no 1959 0.40845421543383 2820 2974689 YIL048W NEO1 SGTC_863 0466-0191 129 µM -0.231926701877642 0.417145534891117 no 1960 0.40829747240477 2923 765160 YPR165W RHO1 SGTC_1743 st037606 46.3785 µM -0.233367196217287 0.416676048863448 no 1961 0.407738141806411 2821 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2405 ticlatone 3.52 µM -0.233611873001774 0.416596315574187 no 1962 0.407643154727049 2715 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.233878896656139 0.416509303983727 no 1963 0.407539498464302 2802 3256 An antibiotic and ribosome inhibitor. SGTC_874 0599-0792 117 µM -0.235008634064956 0.416141216188453 no 1964 0.407101015930158 2996 765305 SGTC_2006 4011487 200 µM -0.235676455737715 0.4159236630148 no 1965 0.406841870457771 2966 45595294 SGTC_2284 7945075 39.21 µM -0.236984419401473 0.415497648447254 no 1966 0.406334438761483 2972 1245402 SGTC_2786 7743617 45.45 µM -0.237840664083436 0.415218816236143 no 1967 0.406002339050141 2857 583674 SGTC_57 miconazole 162.5 nM -0.239628472942463 0.414636762155353 no 1968 0.405309144779988 2785 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1932 st074806 40.9 µM -0.240428092960058 0.414376491708378 no 1969 0.404999200887165 3070 17251235 SGTC_366 0181-0206 4.31 µM -0.241836900718832 0.413918026651447 no 1970 0.404453272388185 2994 274874 SGTC_2592 piperlongumine 83.33 µM -0.241964795638731 0.413876411901276 no 1971 0.404403720892561 2913 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1152 3909-8331 15.9 µM -0.242190524042976 0.413802966221689 no 1972 0.404316268619523 2847 16001939 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.242290926167706 0.413770299160346 no 1973 0.404277372108657 2856 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_103 0844-0104 51.839 µM -0.242348613650091 0.413751530101118 no 1974 0.404255023987831 2943 5375804 SGTC_196 k015-0023 18.111 µM -0.242465135594314 0.413713619405197 no 1975 0.404209884359506 2818 5211998 SGTC_3012 9080433 71.4286 µM -0.242755465699527 0.413619163303535 no 1976 0.404097418449455 2936 17688859 SGTC_1896 st058441 89 µM -0.244060078449867 0.413194781886141 no 1977 0.403592145255559 2857 688759 SGTC_676 falcarinol 140 µM -0.244768901120359 0.412964249304853 no 1978 0.403317687429831 3015 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1090 efavirenz 20.7 µM -0.245883682377743 0.412601746305727 no 1979 0.402886137849434 2887 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_823 0417-1665 178 µM -0.248346955947451 0.411801007191357 no 1980 0.401932985548844 2946 3429856 SGTC_2602 kawain 100 µM -0.248902565756927 0.411620445111207 no 1981 0.401718075280334 2811 5369129 SGTC_2259 7964009 200 µM -0.249327102951227 0.411482491621397 no 1982 0.40155388401827 2993 313134 SGTC_699 0375-0592 111 µM -0.25175192347964 0.410694755694538 no 1983 0.400616410036132 2937 762578 SGTC_687 k029-0044 34.9 µM -0.251778965430048 0.410685972773532 no 1984 0.40060595840635 2983 5829338 SGTC_2178 5812956 200 µM -0.252283157952002 0.410522224925689 no 1985 0.400411102603591 2787 5403383 SGTC_1445 4239-0156 97.7 µM -0.25265785293756 0.41040054441205 no 1986 0.400266309897496 3033 4008346 SGTC_1992 st073643 23.3 µM -0.253024610026398 0.410281450047116 no 1987 0.400124597892684 2822 3161292 SGTC_1209 2323-2347 50.3 µM -0.253247087413186 0.410209210612609 no 1988 0.400038640817151 2866 5412760 SGTC_834 0312-0008 75.7 µM -0.25419679950062 0.409900869006609 no 1989 0.399671761524118 2845 6385573 YIL048W NEO1 SGTC_3040 9091894 49.47 µM -0.254486022632084 0.409806978421068 no 1990 0.399560050526469 2854 25236966 SGTC_409 arachidonic acid 100 µM -0.256179786502807 0.409257235376612 no 1991 0.398906007994504 2866 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_308 4092-1169 104 µM -0.257207057064868 0.408923902165935 no 1992 0.398509468242425 2873 2268590 YDL196W YDL196W SGTC_1491 4138-0063 26.5 µM -0.25731346731117 0.408889377467608 no 1993 0.398468398489287 2870 23883227 SGTC_1855 st056195 39.6 µM -0.257844338668101 0.408717147350619 no 1994 0.398263521911874 3044 4028379 SGTC_1739 st037196 92.5 µM -0.258525895568019 0.408496056303761 no 1995 0.39800053312095 3045 612214 SGTC_1048 3161-0300 24.5 µM -0.258550920264199 0.408487939066863 no 1996 0.397990877853685 2850 2165101 SGTC_2932 9016711 44.54 µM -0.260188875017853 0.407956722784321 no 1997 0.397359042634043 2987 7117328 SGTC_2684 capsaicin 100 µM -0.26040707806021 0.407885968613485 no 1998 0.397274891873131 2958 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2 0422-0095 29 µM -0.260706457886631 0.40778889707659 no 1999 0.397159442784889 2879 6790840 SGTC_2479 5617353 43.85 µM -0.261065813903469 0.407672386210746 no 2000 0.397020877129245 3021 2731746 SGTC_2311 7694451 200 µM -0.263335519985906 0.406936688278074 no 2001 0.39614599226409 2940 2163142 SGTC_1308 1187-1617 41.4 µM -0.263759976717343 0.406799142089905 no 2002 0.395982438327353 2851 2882570 SGTC_1633 st005664 67.9 µM -0.264878016746838 0.406436893688882 no 2003 0.395551716870247 2843 2063822 SGTC_2288 7946289 167.31 µM -0.265621610214318 0.406196011434558 no 2004 0.395265320378817 3066 1246052 SGTC_2820 7989630 71.43 µM -0.266827230606867 0.405805534051047 no 2005 0.394801093566919 2942 2984098 SGTC_1989 st071868 50.2 µM -0.267033995193983 0.405738576358475 no 2006 0.39472149338527 3020 16414057 SGTC_2690 usnic acid 100 µM -0.267948193553906 0.405442559645917 no 2007 0.394369598234684 3119 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1464 k208-0027 110 µM -0.268654410667391 0.405213924110203 no 2008 0.39409781865484 3066 X1464 SGTC_1066 ketoconazole 628 nM -0.268966877234589 0.40511277437346 no 2009 0.393977585915323 3034 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_287 k060-0039 29.6 µM -0.270385711101105 0.404653558114071 no 2010 0.393431765872432 3015 5861974 SGTC_1859 st055998 20 µM -0.271170007210277 0.404399771083118 no 2011 0.393130139897002 3072 676301 SGTC_2505 galangin 7.89 µM -0.271401146427325 0.404324985398945 no 2012 0.393041260200305 2834 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_36 0335-0881 14.2 µM -0.27147719149041 0.404300381588658 no 2013 0.393012019898536 2873 23828853 SGTC_285 1486-1325 46 µM -0.272438926169271 0.403989252234176 no 2014 0.392642272727978 3004 22310230 SGTC_814 3342-0569 96 µM -0.272995853763895 0.403809109170078 no 2015 0.39242820139156 2887 4346283 SGTC_3135 9127742 49.47 µM -0.273027541446781 0.403798860127083 no 2016 0.39241602228598 2945 3643468 SGTC_213 1246-0773 967 nM -0.273367909487677 0.403688775881658 no 2017 0.392285209070577 2920 6251622 SGTC_2804 7954240 19.48 µM -0.273394917892269 0.403680040958514 no 2018 0.392274829485882 3047 828705 SGTC_1578 josamycin 24.2 µM -0.275286155957531 0.40306850590312 no 2019 0.391548199840962 2902 5282165 A P450 substrate. SGTC_1441 4106-0040 13 µM -0.277980123178275 0.402197816586215 no 2020 0.390513808527276 2891 2904180 SGTC_438 sphingosine 6.67 µM -0.278395867605196 0.402063491220959 no 2021 0.390354245676579 2872 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_650 1328-0195 38 µM -0.280061933315148 0.401525308241207 no 2022 0.38971499464083 2979 2780821 SGTC_2977 9011197 71.43 µM -0.280965630453223 0.401233468379586 no 2023 0.389368380656189 3114 2704722 SGTC_752 1896-0090 130 µM -0.281806523351247 0.400961959992425 no 2024 0.389045934334293 2900 772567 SGTC_154 3389-1638 511.116 µM -0.28205312101634 0.400882347341577 no 2025 0.388951389195993 2993 5238686 SGTC_3230 9131665 49.47 µM -0.286648870458811 0.399399392420834 no 2026 0.387190595351102 2901 15943720 SGTC_2432 5630864 12.22 µM -0.286799753401852 0.399350730036685 no 2027 0.387132825884598 3048 5714970 SGTC_553 k007-0256 45.7 µM -0.290201145455356 0.398254138052989 no 2028 0.385831179978172 2971 6287000 SGTC_1956 st077085 54 µM -0.291431571185961 0.397857652218822 no 2029 0.385360635803764 2953 24208685 SGTC_3144 9087057 49.47 µM -0.292394834529926 0.397547328951491 no 2030 0.384992378603095 3031 17249618 SGTC_95 0471-0001 561.058 µM -0.292639480015363 0.397468524696748 no 2031 0.384898866723261 2926 4015405 SGTC_1224 0823-0416 294 µM -0.292784346265322 0.397421862914649 no 2032 0.384843497038549 3062 3598164 SGTC_3339 9145883 14.936 µM -0.293528161127204 0.397182301415375 no 2033 0.384559238743767 3061 2030670 SGTC_234 nsc-17383 10.7 µM -0.293772669538844 0.397103560713123 no 2034 0.384465810294668 3075 408974 SGTC_53 0973-0023 39.979 µM -0.294632137667852 0.396826813664027 no 2035 0.384137454534642 2918 674768 SGTC_1438 4092-1045 4 µM -0.2979980573122 0.395743495541182 no 2036 0.382852323172557 2932 1351342 SGTC_1041 0206-0046 107 µM -0.298294981996721 0.39564796911914 no 2037 0.38273901692491 2996 50494 SGTC_626 0214-0009 33 µM -0.300560952193645 0.394919169464757 no 2038 0.381874655491089 3066 3437874 SGTC_2888 9058547 12.99 µM -0.300732097912535 0.394864139090757 no 2039 0.381809395271888 2932 16476514 SGTC_1647 st011722 22.4 µM -0.300980940058743 0.394784129868098 no 2040 0.381714514327718 3092 2854783 SGTC_3183 9108214 49.47 µM -0.30099709645686 0.394778935319223 no 2041 0.381708354305332 3024 4974831 SGTC_2878 9043973 25.97 µM -0.301234616019831 0.394702571015615 no 2042 0.38161779761422 3075 6465167 SGTC_1600 coumarin 106 71.1 µM -0.301253245883364 0.394696581547187 no 2043 0.38161069506778 3101 100336 A hepatotoxic, DNA x-linker. SGTC_1105 epirubicin 18.1 µM -0.301855126474488 0.394503091392884 no 2044 0.381381252428269 2914 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_1868 st057644 42.7 µM -0.303391439165805 0.394009321862642 no 2045 0.380795784491225 2914 688665 SGTC_2662 daunorubicin 22.37 µM -0.306008261784027 0.393168669927661 no 2046 0.379799177672138 2928 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_697 0508-1955 564 µM -0.307770257698677 0.392602910551011 no 2047 0.379128577340445 3117 6243113 SGTC_337 1315-0038 354 µM -0.308346575743124 0.392417909733612 no 2048 0.378909314514434 2964 1626437 SGTC_2252 omeprazole 400 µM -0.309602590517873 0.392014807324804 no 2049 0.378431593040989 2975 4594 A proton pump inhibitor. SGTC_1463 k081-0032 34.1 µM -0.310415151624875 0.391754087588292 no 2050 0.378122636750597 3020 977755 SGTC_222 nsc-310342 10.666 µM -0.31140715364577 0.391435858038018 no 2051 0.377745558132484 3034 432556 SGTC_1019 4262-0212 3.4 µM -0.311605717248912 0.391372168493865 no 2052 0.377670094352691 3030 4677213 SGTC_2546 rhodinyl acetate 100 µM -0.312890450615136 0.390960158978879 no 2053 0.37718194644451 3111 6708682 SGTC_1503 4585-0012 61.3 µM -0.314418399796015 0.390470310322996 no 2054 0.376601641611024 3140 2922052 SGTC_1170 0310-0127 64.8 µM -0.316249380877915 0.389883540972611 no 2055 0.37590661452166 3028 774975 SGTC_1785 bathophenanthroline 24 µM -0.316959298138278 0.389656103200121 no 2056 0.375637243222392 2975 72812 An iron chelator. SGTC_885 0865-0106 16.8 µM -0.317737176469121 0.3894069359715 no 2057 0.375342154337074 2967 2793380 SGTC_1345 1488-0192 31.4 µM -0.318695378004966 0.389100070751068 no 2058 0.374978759931866 3118 658348 SGTC_1665 st014639 11.4 µM -0.319178937173117 0.388945236578492 no 2059 0.37479541400396 3002 981133 YIL048W NEO1 SGTC_424 splitomicin 100 mM -0.319922845001649 0.388707074001598 no 2060 0.374513409737287 3052 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2294 7971431 200 µM -0.320402436512079 0.388553554634548 no 2061 0.37433163937921 3105 5741572 SGTC_2902 5787006 60.46 µM -0.322067316242821 0.388020754492914 no 2062 0.373700848998049 2967 591003 SGTC_2166 5933061 31.504 µM -0.322786297212349 0.387790728990152 no 2063 0.373428545617597 3437 2877375 SGTC_1579 chlormadinone acetate 49.4 µM -0.322980058248329 0.387728745235946 no 2064 0.373355172302229 3117 45114258 A steroidal progestin. SGTC_2810 7959871 45.46 µM -0.32325846456407 0.387639688641054 no 2065 0.373249753601208 3067 2974535 SGTC_2792 7535235 81.82 µM -0.324020265623038 0.387396033994706 no 2066 0.372961345738005 3040 1281891 SGTC_1700 st030840 7.9285 µM -0.324451222855415 0.387258216157229 no 2067 0.37279822251129 3080 5499307 SGTC_334 1502-1024 68.5 µM -0.324845887853478 0.3871320168478 no 2068 0.372648856399594 3073 3296216 SGTC_2707 st078556 66.6 µM -0.325834899664751 0.386815819780216 no 2069 0.372274636153029 3046 17250899 SGTC_1946 st076057 65.1 µM -0.329115826756825 0.385767413214233 no 2070 0.371034071002801 2953 953009 SGTC_1851 st056236 18.9 µM -0.331858783520143 0.38489155245217 no 2071 0.369997947127552 3166 5393171 SGTC_1832 st054113 55 µM -0.332216686691197 0.384777312648508 no 2072 0.369862822244405 3115 1251267 SGTC_2238 6671620 73.2395 µM -0.33495980544655 0.383902064104824 no 2073 0.368827703515367 2929 729941 SGTC_2506 ethyl hematommate 54.16 µM -0.335875293280296 0.383610090358285 no 2074 0.368482454464065 3061 3940691 An allergen. SGTC_80 0159-0065 512.242 µM -0.336640219054393 0.383366185570435 no 2075 0.368194066806668 2983 1548079 SGTC_1185 1319-0113 81.3 µM -0.336796277120207 0.383316430455694 no 2076 0.36813523985972 3095 4672763 SGTC_3273 9137859 49.47 µM -0.337260333067344 0.383168489482809 no 2077 0.36796032968754 3081 2377234 SGTC_3101 9120531 49.47 µM -0.339184626292663 0.382555207091587 no 2078 0.367235324992391 3209 24824904 SGTC_2393 9031399 185.94 µM -0.33942892215895 0.382477369741437 no 2079 0.367143316859093 3134 1526623 YDL150W RPC53 SGTC_1242 0402-0103 60.1 µM -0.33988207362521 0.382332999563647 no 2080 0.366972668516531 2969 432868 SGTC_2317 5986382 200 µM -0.340473021244584 0.382144753284951 no 2081 0.366750168215398 3069 877883 SGTC_1938 st074717 56.4 µM -0.340809627709102 0.382037539793827 no 2082 0.366623451032922 2941 17250979 SGTC_2918 7977171 22.06 µM -0.342292882331094 0.381565211958665 no 2083 0.366065245754517 2982 2236483 SGTC_910 3454-3003 490 µM -0.34349101696465 0.381183806466412 no 2084 0.36561454882195 3141 820824 SGTC_784 4579-0127 173 µM -0.343808081863643 0.381082893617709 no 2085 0.36549531094804 3206 1948547 SGTC_2957 9076800 11.52 µM -0.345459259012335 0.38055750117954 no 2086 0.364874566848316 3043 16459615 SGTC_2463 5473429 200 µM -0.347300920280254 0.37997175792032 no 2087 0.364182629741458 3065 5399405 SGTC_2462 5162487 171.77 µM -0.347358072096897 0.379953585091543 no 2088 0.36416116409637 3022 2259986 SGTC_1125 tnp00248 1.32998 µM -0.351026629759646 0.378787633013464 no 2089 0.362784185187604 3185 24207736 SGTC_1777 st045864 34.765 µM -0.351109355194639 0.378761353634895 no 2090 0.362753154885602 3102 4691462 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.351877371381011 0.378517404802261 no 2091 0.362465115144093 3167 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2818 7996756 12.99 µM -0.35266087974642 0.378268584989253 no 2092 0.36217134535959 2944 2241621 SGTC_1347 1493-0251 600 nM -0.354263179958662 0.377759897593616 no 2093 0.361570829423989 3159 3986378 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.354827630382854 0.377580750134611 no 2094 0.36135936372825 3144 1377 SGTC_3208 9114115 49.47 µM -0.354898821912632 0.37755815696083 no 2095 0.36133269554118 3094 650895 SGTC_1205 4161-2785 76 µM -0.3558365780645 0.377260592042963 no 2096 0.360981477130404 3128 3498106 SGTC_132 0417-1715 25.805 µM -0.357918792093514 0.376600133202739 no 2097 0.360202043522884 3189 6769098 SGTC_2049 5262831 67.185 µM -0.358132210356119 0.376532459290509 no 2098 0.360122187583808 3103 763417 SGTC_1091 telmisartan 47.6 µM -0.361559692813598 0.37544614211385 no 2099 0.358840545029882 3145 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_3327 9140648 26.9345 µM -0.362741431116363 0.375071826564526 no 2100 0.358399023549139 3163 8029710 SGTC_3234 9132280 49.47 µM -0.362992329982399 0.374992369487455 no 2101 0.358305306960657 3109 17612295 SGTC_1171 0368-0077 21.4 µM -0.363380878957678 0.374869330514462 no 2102 0.358160191685036 3022 3239779 SGTC_714 4296-0578 26.1 µM -0.365286774680533 0.374265989059307 no 2103 0.357448674806562 3038 1589775 SGTC_3055 9094636 49.47 µM -0.36617379658368 0.373985293109479 no 2104 0.357117696844595 3227 25236176 SGTC_198 3454-2873 16.191 µM -0.368572916469779 0.373226432475425 no 2105 0.35622304297754 3064 710957 SGTC_1846 st056244 14.8 µM -0.36878281526593 0.373160063161795 no 2106 0.356144807339567 3095 5393182 SGTC_1267 0828-0272 9.49 µM -0.370843365705842 0.372508723948363 no 2107 0.355377099776741 3201 745334 SGTC_2028 5153890 36.43 µM -0.371809139338527 0.372203568591889 no 2108 0.355017479275417 3059 2830968 YPR165W RHO1 SGTC_3116 9124943 49.47 µM -0.372254275369991 0.372062946025076 no 2109 0.354851769554549 3085 41905195 YPL160W CDC60 SGTC_592 k241-0073 46.5 µM -0.372478386073536 0.3719921538487 no 2110 0.354768350791147 3197 4230158 SGTC_1261 0712-0010 12.7 µM -0.373991530668182 0.371514294488962 no 2111 0.354205308639525 3237 2840123 SGTC_880 0833-0487 87.2 µM -0.375072129099799 0.371173156688348 no 2112 0.35380341211686 3055 76075 SGTC_1155 4088-0394 48.2 µM -0.375177414469502 0.371139924197357 no 2113 0.353764263047952 3038 2326248 SGTC_1305 1181-0477 144 µM -0.375351061716328 0.371085115921996 no 2114 0.353699697835044 3202 6252086 SGTC_556 4058-0063 51.5 µM -0.376311856126371 0.370781907697486 no 2115 0.35334253305511 3113 6615692 SGTC_541 4513-1321 94 µM -0.378465370525656 0.370102591681246 no 2116 0.352542457146222 3072 747515 SGTC_611 3453-1652 23.7 µM -0.378911707749449 0.369961847299992 no 2117 0.352376714919838 3171 1560575 SGTC_2262 9014885 67.46 µM -0.38115109183222 0.369255961199794 no 2118 0.351545568896369 3045 6457424 SGTC_2700 st077718 96.8 µM -0.381776814956928 0.369058802917351 no 2119 0.351313458742661 3119 904970 SGTC_3218 9131285 49.47 µM -0.3897335575791 0.366554743315633 no 2120 0.348366789720529 3261 17156417 SGTC_3333 9141820 12.094 µM -0.39070195416346 0.366250364976009 no 2121 0.348008777119877 3079 1939433 SGTC_202 3594-0513 34.79 µM -0.392605903587274 0.365652176932423 no 2122 0.347305289280303 3109 708429 SGTC_2270 7924575 90.91 µM -0.39439037103794 0.365091824472698 no 2123 0.346646425856515 3231 1262135 SGTC_313 3474-0040 5.03 µM -0.394512990963884 0.365053330336326 no 2124 0.346601168965764 3059 1043375 YIL048W NEO1 SGTC_3073 9114972 49.47 µM -0.395466564992839 0.364754020787353 no 2125 0.346249296064772 3187 41905075 SGTC_1976 st070609 63.5 µM -0.396441745378119 0.364448014628269 no 2126 0.345889587539562 3057 682556 SGTC_628 1636-0253 16 µM -0.396538604676718 0.364417625433403 no 2127 0.34585386725821 3163 4456143 SGTC_381 3461-2219 42.7 µM -0.397677342589936 0.364060415184686 no 2128 0.345434020457567 3202 2883159 SGTC_1135 dihydrocapsaicin 536.708 nM -0.398678249194447 0.363746538675789 no 2129 0.345065148300618 3042 107982 A Capsaicinoid. SGTC_336 4111-0029 111 µM -0.399017624038683 0.363640134112629 no 2130 0.344940109154628 3122 3131175 SGTC_2473 5854593 8.94 µM -0.399383134904696 0.363525546857367 no 2131 0.344805459399785 3040 2872951 SGTC_1278 0874-0585 172 µM -0.399569942442738 0.36346698761294 no 2132 0.344736649364802 3171 766306 SGTC_3080 9117754 49.47 µM -0.400617307741899 0.363138725289728 no 2133 0.344350950460338 3314 9550191 SGTC_1900 st060200 72.8 µM -0.401913442130126 0.362732633619398 no 2134 0.343873864815517 3095 688945 SGTC_1674 st016616 23.6 µM -0.403515987999394 0.362230753633484 no 2135 0.343284337757875 3072 625830 SGTC_232 clozapine 119 µM -0.403584086597215 0.362209431978772 no 2136 0.343259294822338 3143 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_2002 4023503 131 µM -0.403678621183108 0.362179833931186 no 2137 0.343224531318806 3296 4736863 YCR052W RSC6 SGTC_2743 auranofin 4.32 µM -0.404423320103847 0.361946703285545 no 2138 0.342950727226936 3137 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_609 0986-0026 86.3 µM -0.404880914606944 0.361803477096965 no 2139 0.342782523951806 3120 2848610 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.406678441650043 0.361241042153818 no 2140 0.342122088155163 3138 688669 SGTC_917 harmaline 728.087 nM -0.407262318816796 0.361058415096383 no 2141 0.34190766752667 3200 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2129 girgensonine 121.053 µM -0.410715936114463 0.359978829992247 no 2142 0.340640420092567 3165 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2608 thymoquinone 42.66 µM -0.413888877876993 0.358987966034585 no 2143 0.339477744796327 3218 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_443 clozapine 122 µM -0.415176003233222 0.358586285239961 no 2144 0.339006532163335 3211 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1734 st037168 69.4 µM -0.41578037457655 0.358397729441277 no 2145 0.338785360488907 3195 708907 SGTC_1394 3474-0001 65.7 µM -0.415941191267963 0.358347562591317 no 2146 0.338726518451333 3172 5017666 YIL048W NEO1 SGTC_2754 granisetron 64.02 µM -0.417651653253332 0.35781413454035 no 2147 0.338100912615756 3272 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_2381 9035592 200 µM -0.422551969270671 0.356287452027097 no 2148 0.336311088110499 3186 4749657 SGTC_855 0428-0020 25 µM -0.422582827837822 0.356277845373619 no 2149 0.33629982881247 3163 6812414 SGTC_2481 5478948 45.16 µM -0.422902630495835 0.356178292224121 no 2150 0.336183151761798 3277 77792 SGTC_1669 st015249 58.4 µM -0.42534326296786 0.355418857471794 no 2151 0.335293229937662 3258 722793 SGTC_2147 5545932 89.7195 µM -0.425670231637679 0.355317160402523 no 2152 0.335174078195801 3200 797404 SGTC_18 0111-0177 500 nM -0.426174008131613 0.355160490960734 no 2153 0.334990527786963 3186 721752 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.426224661531239 0.355144739615065 no 2154 0.334972074456288 3156 390807 SGTC_2012 4023501 200 µM -0.429431242101826 0.354148115718875 no 2155 0.333804710865311 3205 3477460 SGTC_401 neomycin 50 µM -0.430238598180657 0.353897341792323 no 2156 0.333511043644565 3191 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2159 5658611 73.75 µM -0.430710477503341 0.353750800075432 no 2157 0.333339449755315 3276 793844 SGTC_2787 5284540 71.43 µM -0.431179125061578 0.353605283425044 no 2158 0.333169065577065 3185 736958 SGTC_2396 5342950 42.78 µM -0.431985654862133 0.353354903289995 no 2159 0.332875919625725 3221 1886677 SGTC_1924 st058459 75.1 µM -0.432974540694496 0.353047998918302 no 2160 0.33251663288021 3255 688683 SGTC_2207 7258803 200 µM -0.434013598984067 0.352725626304208 no 2161 0.332139282944974 3243 3666799 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.434456461868641 0.352588258176435 no 2162 0.331978502194943 3216 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_3328 9140624 29.0385 µM -0.434896698957515 0.352451723573461 no 2163 0.331818705393743 3284 4904392 SGTC_898 1000-0849 28.3 µM -0.43563915667025 0.352221501699878 no 2164 0.331549278178599 3251 6751807 SGTC_1129 3453-1384 223 µM -0.435884390145883 0.352145471401654 no 2165 0.331460305617342 3334 1084452 SGTC_230 MPP+ 141.667 µM -0.436518155542235 0.35194901103632 no 2166 0.331230414791338 3223 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_61 0978-8327 98.565 µM -0.436581984986906 0.351929226793727 no 2167 0.331207264946365 3271 6150059 YHR072W ERG7 SGTC_111 0083-0039 52.457 µM -0.43670308621965 0.351891691987491 no 2168 0.331163345379098 3104 759313 SGTC_247 mechlorethamine 29.705 µM -0.438710322496025 0.351269768207091 no 2169 0.330435723279417 3171 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_64 000l-0018 272.079 µM -0.439934951678157 0.350890523466023 no 2170 0.329992110264067 3151 6811119 SGTC_2944 9067346 25.62 µM -0.441303019897077 0.350467033954795 no 2171 0.329496820079028 3311 6473075 SGTC_2467 5474540 200 µM -0.441315830881661 0.350463069154403 no 2172 0.329492183450759 3150 5413519 SGTC_2366 9070441 60.58 µM -0.442113267972234 0.350216306867967 no 2173 0.329203621867848 3175 6837235 SGTC_1697 st025554 27.742 µM -0.442239297281517 0.350177313611286 no 2174 0.329158026048695 3153 1269519 SGTC_1027 k015-0025 8.67 µM -0.443617664013794 0.349750952435605 no 2175 0.328659516305831 3145 3598955 SGTC_3271 9137798 49.47 µM -0.443856224205387 0.349677179383814 no 2176 0.328573267873381 3262 6498326 SGTC_3014 9081533 49.47 µM -0.444480335600739 0.349484204204519 no 2177 0.328347671466182 3304 21367265 SGTC_3168 9103419 49.47 µM -0.444822496133356 0.349378424706211 no 2178 0.328224017874265 3246 16649256 SGTC_936 3005-4620 401 µM -0.445393211768223 0.34920201304783 no 2179 0.328017808500897 3367 777207 SGTC_2491 paeonol 100 µM -0.445973693427171 0.3490226160704 no 2180 0.32780812425862 3164 11092 Increases levels of cortical cytochrome oxidase. SGTC_1483 3453-0561 55.9 µM -0.44699645832485 0.348706614237927 no 2181 0.327438808536612 3272 4546991 SGTC_3157 9099274 49.47 µM -0.448628587395654 0.348202555660199 no 2182 0.326849803950351 3325 17217662 SGTC_1794 st048918 76.9 µM -0.449682798676603 0.347877120731467 no 2183 0.326469588077885 3252 672303 SGTC_94 0334-0113 514.748 µM -0.452234867141545 0.347089761698825 no 2184 0.32554989611762 3223 6795178 SGTC_785 1270-0111 65.3 µM -0.453302673712342 0.346760519699516 no 2185 0.325165403903676 3167 6741994 SGTC_91 0417-1751 58.384 µM -0.45360597744231 0.346667021670549 no 2186 0.325056225228319 3298 6795624 SGTC_3321 9137793 26.8275 µM -0.457128331637406 0.345581887219464 no 2187 0.32378940373039 3283 4904192 SGTC_685 1278-0033 54.9 µM -0.457240588321464 0.345547325011376 no 2188 0.323749063843759 3334 3590572 SGTC_2151 5563267 85.4165 µM -0.457619993298707 0.345430521241939 no 2189 0.323612738480875 3233 5310824 SGTC_3244 9134489 49.47 µM -0.457929302873389 0.345335307961022 no 2190 0.323501616860048 3286 16584271 SGTC_2487 5918373 44.05 µM -0.459330382429227 0.344904143021007 no 2191 0.322998466493098 3382 2876279 SGTC_1303 1160-0052 261 µM -0.46097142905326 0.344399387192996 no 2192 0.322409551733302 3278 3562476 SGTC_1109 tnp00067 928.257 nM -0.461309259539613 0.344295511086081 no 2193 0.3222883713139 3245 676295 SGTC_1769 st044406 64.4 µM -0.463878964949323 0.343505763085485 no 2194 0.321367232137814 3188 670903 SGTC_384 k007-0144 5.16 µM -0.464926915472913 0.343183892042052 no 2195 0.320991897483723 3244 6824886 SGTC_2212 7123476 200 µM -0.466700090594411 0.342639532201704 no 2196 0.320357232467051 3242 1085715 SGTC_3083 9117465 49.47 µM -0.470351124336539 0.341519704646017 no 2197 0.319052088629049 3286 16420915 SGTC_16 erodoxin 22.806 µM -0.47058788992283 0.341447133055692 no 2198 0.318967528636733 3353 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1694 st024011 44.9 µM -0.471639365743921 0.34112491352275 no 2199 0.318592111637548 3330 2787533 SGTC_1825 st052143 62.6 µM -0.475995200827085 0.339791325511917 no 2200 0.317038898481057 3368 674173 SGTC_1897 st060201 15 µM -0.476071091146312 0.339768108538612 no 2201 0.31701186579257 3249 611878 SGTC_3197 9113331 49.47 µM -0.478042185326555 0.339165308790478 no 2202 0.316310090039659 3414 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_3215 9129942 49.47 µM -0.478320804114052 0.339080134786986 no 2203 0.316210945658048 3338 17682944 SGTC_1365 1672-3266 55.4 µM -0.478686932290042 0.33896822159262 no 2204 0.31608068181361 3348 6415873 SGTC_1376 2910-0861 41.3 µM -0.479847442400284 0.33861358623105 no 2205 0.315667937691134 3297 1112859 SGTC_1809 st050081 57.6 µM -0.480015254981303 0.338562316927219 no 2206 0.315608272894005 3408 5036894 SGTC_178 4092-0806 87.505 µM -0.480928422022048 0.338283382920153 no 2207 0.315283685873476 3336 2169044 SGTC_1970 st070122 35.8 µM -0.480967671058908 0.338271395982905 no 2208 0.315269737919064 3394 102928 SGTC_1711 st032263 62.8 µM -0.481863896947558 0.337997726797282 no 2209 0.314951317254985 3288 3958979 SGTC_1401 3807-4679 7.6 µM -0.483246742251785 0.337575632751215 no 2210 0.314460275061628 3319 3291456 SGTC_1 0258-0098 57.368 µM -0.483414108046616 0.337524560546692 no 2211 0.314400866454252 3251 6790032 YDR047W HEM12 SGTC_197 4544-0043 41.561 µM -0.483916385143411 0.337371307063484 no 2212 0.314222605702402 3317 896523 SGTC_199 4063-0024 41.6 µM -0.484854014418337 0.337085292250224 no 2213 0.313889952148589 3347 306215 SGTC_262 fenpropimorph 62.5 µM -0.48505413354692 0.337024260016553 no 2214 0.313818973147732 3300 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_3336 9143619 71.43 µM -0.485205313315336 0.336978156129473 no 2215 0.313765356710288 3364 45595730 SGTC_2227 7312221 64.1025 µM -0.485391005276872 0.336921530731422 no 2216 0.313699505784044 3310 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_45 0kpi-0036 14.9 µM -0.48541272024629 0.336914909152537 no 2217 0.313691805510602 3367 2795021 SGTC_2421 5690543 90.72 µM -0.486749112828078 0.336507498254313 no 2218 0.313218068072186 3327 3397993 SGTC_2890 9046729 58.44 µM -0.48885101614232 0.335867103071968 no 2219 0.312473588488864 3225 903329 SGTC_1104 tacrolimus 29.8 µM -0.488887262037149 0.33585606406408 no 2220 0.312460757142934 3354 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_2217 6934799 96.0675 µM -0.491896586803341 0.334940042342392 no 2221 0.311396225656145 3337 675606 SGTC_280 3448-3607 3.04 µM -0.492018078247919 0.334903081590459 no 2222 0.31135328176944 3357 626179 SGTC_1486 3970-0793 4.53 µM -0.49232225774322 0.334810549554857 no 2223 0.311245773937629 3360 2844330 SGTC_1253 0550-0034 176 µM -0.492337196073283 0.33480600554207 no 2224 0.311240494616138 3352 5969915 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.492426425122696 0.334778863926212 no 2225 0.311208961187949 3415 165506 SGTC_2517 totarol 10 µM -0.493465276711542 0.334462930493487 no 2226 0.310841934425609 3323 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1381 2324-0066 62.1 µM -0.495643232929032 0.333800955494866 no 2227 0.310073072376731 3325 10885928 SGTC_83 0170-0301 39.027 µM -0.495829479997619 0.333744370928191 no 2228 0.310007361903929 3330 3089716 SGTC_1070 indatraline 8.81 µM -0.496101233670116 0.333661814995724 no 2229 0.309911494436786 3290 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_615 k087-0205 167 µM -0.497118204692494 0.333352941286207 no 2230 0.309552848831093 3278 9642773 SGTC_815 1582-0027 36.9 µM -0.497798632622741 0.333146345264037 no 2231 0.3093129899098 3358 3128206 SGTC_1402 3909-7673 35.9 µM -0.500293632234194 0.332389230537101 no 2232 0.308434168587379 3330 5328014 SGTC_533 1222-0222 6.71 µM -0.502828326794382 0.331620769969405 no 2233 0.307542488004021 3424 3982874 SGTC_535 2293-4129 48.2 µM -0.505280350478047 0.330878047008041 no 2234 0.306680970953271 3409 396118 YIL048W NEO1 SGTC_1940 st075990 51.1 µM -0.506060232030601 0.330641958588947 no 2235 0.306407183447629 3499 1084979 SGTC_1454 4239-0054 42.6 µM -0.50610424856011 0.330628635761616 no 2236 0.306391734095272 3455 1340767 SGTC_3001 9076041 71.4286 µM -0.507427044809508 0.330228354866936 no 2237 0.305927606804561 3325 16004211 SGTC_734 2023-0417 80 µM -0.513741447795168 0.328320286340504 no 2238 0.303716384781023 3379 3935732 SGTC_3212 9128307 49.47 µM -0.518196332445702 0.326976807335286 no 2239 0.3021606467039 3176 27243542 SGTC_1753 st043925 64 µM -0.518727036497905 0.326816909544543 no 2240 0.301975552533554 3376 670181 SGTC_478 N-arachidonylglycine 10 µM -0.518994402283302 0.326736365959357 no 2241 0.301882322404258 3344 5283389 SGTC_1173 0443-0020 122 µM -0.520421000704035 0.326306741639518 no 2242 0.301385088016421 3309 5331295 SGTC_2323 6148992 148.28 µM -0.520611810976141 0.32624929601775 no 2243 0.301318609928001 3279 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_3216 9129716 49.47 µM -0.52083621766672 0.326181741083237 no 2244 0.301240435334433 3307 8056934 SGTC_2483 5729050 27.16 µM -0.521097827774214 0.326102993707468 no 2245 0.301149312046559 3459 2865180 SGTC_1525 8-methoxypsoralen 92.5 µM -0.52119847013355 0.326072701370822 no 2246 0.301114259894689 3480 4114 Related to psoralen; DNA damaging agent. SGTC_1606 st000094 49.2 µM -0.522641445184966 0.325638506689397 no 2247 0.300611896650609 3442 1242210 SGTC_1948 st076329 66.6 µM -0.523494874674564 0.325381818931232 no 2248 0.300314958395966 3341 24208413 SGTC_164 4100-3994 89.624 µM -0.524723510509898 0.325012425029414 no 2249 0.29988770556234 3464 4615967 SGTC_2571 chrysanthemic acid 100 µM -0.528291444056999 0.323940688364785 no 2250 0.298648534557638 3332 2743 An insecticide. SGTC_3162 9099653 49.47 µM -0.530040107337698 0.323415956246341 no 2251 0.298042061623288 3403 25237511 SGTC_2150 5556613 200 µM -0.532471947364684 0.322686802731448 no 2252 0.29719958301666 3340 743190 SGTC_2889 9059656 51.95 µM -0.534119532924379 0.322193183981938 no 2253 0.296629418234417 3403 3949838 SGTC_843 0310-0051 143 µM -0.534704478346412 0.322018008930142 no 2254 0.296427112132196 3372 2065037 SGTC_653 0203-0016 55.2 µM -0.535373027569685 0.321817845259813 no 2255 0.296195968743977 3379 295302 SGTC_758 0868-0029 16 µM -0.535392339264153 0.321812064105499 no 2256 0.296189293171257 3442 762687 SGTC_926 2268-1401 59.4 µM -0.53573772392696 0.321708676940814 no 2257 0.296069913936533 3423 2931578 SGTC_2516 gossypol 71.55 µM -0.5357911473357 0.321692686453563 no 2258 0.296051450567494 3469 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2998 9066762 71.4286 µM -0.537559377318866 0.321163613258123 no 2259 0.295440640826491 3503 4945196 SGTC_3048 9093155 49.47 µM -0.537864256406576 0.321072426835353 no 2260 0.295335383326451 3420 25236002 SGTC_2710 st078562 53.7235 µM -0.539068716779617 0.32071228978984 no 2261 0.294919720146926 3362 17250908 SGTC_260 nsc-65238 3.989 µM -0.539538654732922 0.320571822743932 no 2262 0.294757616180203 3396 3246252 SGTC_377 3970-0964 33.1 µM -0.539830530732069 0.320484592331559 no 2263 0.294656954943614 3410 16481235 SGTC_2370 9071495 200 µM -0.54077808470631 0.320201473576361 no 2264 0.294330274986221 3384 21791103 SGTC_2588 indole-3-carbinol 100 µM -0.546978018692441 0.318351589716099 no 2265 0.292196916875634 3460 3712 Induces cell cycle arrest. SGTC_658 3253-0951 102 µM -0.547422466344822 0.318219152291808 no 2266 0.292044261995376 3408 1184878 SGTC_2464 5717415 7.67 µM -0.548523183818047 0.317891258292237 no 2267 0.291666357382264 3338 5285744 SGTC_2218 6965428 192.983 µM -0.548564270623675 0.317879021658044 no 2268 0.291652255639424 3424 675684 SGTC_1005 4092-0690 4.4 µM -0.548852171620313 0.317793283429493 no 2269 0.291553451671238 3355 1529343 SGTC_759 3486-0358 89.3 µM -0.549034966111359 0.317738851466935 no 2270 0.291490727024082 3487 875103 SGTC_706 4262-0057 46.9 µM -0.550666079097315 0.31725331832672 no 2271 0.290931300908251 3398 883298 SGTC_2066 5222451 176 µM -0.552396042187904 0.316738703979445 no 2272 0.290338520824239 3415 2281147 SGTC_1498 4478-3555 97.6 µM -0.554702642742551 0.316053107976443 no 2273 0.28954903413484 3443 3437919 SGTC_803 4488-1585 147 µM -0.5549213441239 0.315988135651549 no 2274 0.289474230944534 3442 747204 SGTC_2610 ononetin 44.17 µM -0.555140446886277 0.315923049782478 no 2275 0.289399299571211 3409 259632 SGTC_43 0570-0105 72.5 µM -0.557310157648907 0.315278831695167 no 2276 0.288657768409129 3462 1114046 YDL195W SEC31 SGTC_1196 1588-0294 184 µM -0.55755281601274 0.315206817824434 no 2277 0.288574891948087 3419 6144269 SGTC_1249 0481-0015 10.2 µM -0.558935044017202 0.314796747152054 no 2278 0.288103025856278 3356 4227577 SGTC_1511 0906-3109 28.5 µM -0.560878087904459 0.314220683196717 no 2279 0.287440324322195 3474 2882180 SGTC_2708 st078559 56 µM -0.562122480119007 0.313851989461001 no 2280 0.287016286503302 3421 17250902 SGTC_1442 4112-3290 3 µM -0.562335262599882 0.313788963966906 no 2281 0.286943808635687 3439 704353 SGTC_1143 3454-2408 5.08 µM -0.562563246917278 0.313721441766577 no 2282 0.286866162349065 3444 X1143 SGTC_542 3381-0244 89.3 µM -0.562955314295548 0.313605337616638 no 2283 0.286732656382952 3506 1112843 SGTC_1363 1636-0063 10.4 µM -0.563243694671621 0.313519950408747 no 2284 0.286634476503832 3430 6072185 SGTC_931 2812-0076 566 µM -0.563906735398474 0.313323667058882 no 2285 0.286408802982439 3389 3450959 SGTC_349 k015-0014 24 µM -0.565058845628807 0.312982727716406 no 2286 0.286016869733705 3380 2196908 SGTC_2996 9066192 71.4286 µM -0.565363085671881 0.312892721855636 no 2287 0.285913413697497 3415 6472854 SGTC_3354 9151612 71.43 µM -0.566053546567112 0.312688498449413 no 2288 0.285678690287429 3460 27261949 SGTC_1225 1216-0074 20.6 µM -0.566628905642093 0.312518363583041 no 2289 0.28548316600288 3396 4241466 SGTC_1949 st076024 69.1 µM -0.568129346979626 0.312074867989315 no 2290 0.284973570930036 3383 2921930 SGTC_2114 5491910 81.25 µM -0.570771017116203 0.311294713526639 no 2291 0.284077435869333 3494 2849228 SGTC_2241 6772625 37.8075 µM -0.573133979095763 0.310597586189349 no 2292 0.283276990993927 3458 2285411 SGTC_854 0422-0053 192 µM -0.573143380330887 0.310594813967637 no 2293 0.283273808520918 3490 3596728 SGTC_564 3555-0129 330 µM -0.573490377419565 0.310492499527418 no 2294 0.283156356286944 3436 563260 SGTC_2642 cholecalciferol 100 µM -0.573727188554226 0.310422682577179 no 2295 0.283076213420659 3457 9821465 A vitamin D precursor, similar to steriods. SGTC_6 0844-0013 19.835 µM -0.573815666520282 0.310396599146754 no 2296 0.283046273037066 3549 1584900 SGTC_162 k030-0015 37.8 µM -0.574152282592766 0.310297372964382 no 2297 0.28293237818275 3466 1809920 YMR134W ERG29 SGTC_435 c-PAF 6.7 µM -0.574998550245933 0.310047974967675 no 2298 0.282646138738931 3432 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_566 0958-0068 16.5 µM -0.576649137745654 0.309561792586435 no 2299 0.28208824896494 3498 6815365 SGTC_2886 9058944 51.95 µM -0.579032484617002 0.308860362917307 no 2300 0.281283627179792 3329 4949929 SGTC_2879 9041815 71.43 µM -0.579053431420091 0.308854201263565 no 2301 0.281276560419578 3448 4942971 SGTC_1550 gossypolone 36.6 µM -0.579273236941623 0.308789547122894 no 2302 0.281202410458477 3487 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1425 4048-4433 7.33 µM -0.581550485417444 0.308120060615569 no 2303 0.280434751520351 3533 23734946 SGTC_1169 aniline yellow 25.8 µM -0.581717113658891 0.308071098729216 no 2304 0.280378621108886 3443 6051 A DNA damaging agent. SGTC_1728 st035614 33.7865 µM -0.582042493442339 0.307975499286192 no 2305 0.280269029317507 3417 15945546 SGTC_1685 st024049 53.0905 µM -0.58320432495516 0.307634249327992 no 2306 0.279877880012828 3466 1941139 SGTC_3247 9135149 49.47 µM -0.584622962500087 0.30721779662057 no 2307 0.279400632116608 3463 8934436 YOR116C RPO31 SGTC_1762 st045503 25.4615 µM -0.585973595040063 0.306821538228977 no 2308 0.278946629623666 3476 4645554 SGTC_1420 4'-methoxyflavone 42 µM -0.589323195613923 0.30583978239053 no 2309 0.277822243802854 3494 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_2552 juarezic acid 87.02 µM -0.591603987154031 0.305172087615103 no 2310 0.27705790165406 3554 1549512 SGTC_1028 k015-0029 4.8 µM -0.594251464368202 0.304397859211875 no 2311 0.276171967965381 3512 4588309 SGTC_1667 st014849 34.6 µM -0.594264933407728 0.304393922561398 no 2312 0.276167464335344 3522 5348460 SGTC_740 k014-0057 261 µM -0.594783255447063 0.304242447710265 no 2313 0.275994180874298 3472 4012779 SGTC_3204 9114183 49.47 µM -0.595882086146603 0.303921435630011 no 2314 0.275627000638639 3489 17027248 SGTC_2970 9090938 41.86 µM -0.596421487933402 0.303763910240582 no 2315 0.275446844537132 3545 17217104 SGTC_2993 9054257 71.4286 µM -0.599656645013972 0.302819889565789 no 2316 0.274367543862924 3511 6470217 YGL055W OLE1 SGTC_2327 6189656 200 µM -0.600652671447773 0.302529513195341 no 2317 0.274035674160055 3521 5349088 SGTC_400 oxethazaine 37.5 µM -0.601431941895532 0.302302415806086 no 2318 0.273776164563715 3488 4621 A local anesthetic. SGTC_1939 st074455 53.6 µM -0.602883600432552 0.301879573092213 no 2319 0.273293063235687 3562 1644229 SGTC_1415 3966-0071 78.1 µM -0.604460328723505 0.301420601095167 no 2320 0.272768818432031 3531 2893185 SGTC_289 k017-0060 526 µM -0.604950364985029 0.301278019773956 no 2321 0.27260598845452 3475 5512909 SGTC_2315 7733312 200 µM -0.605117492717454 0.301229399109533 no 2322 0.272550466038947 3466 726316 SGTC_890 0929-0006 47.2 µM -0.606592402530255 0.300800472856971 no 2323 0.272060721736243 3454 1378169 SGTC_1044 1222-0021 1.78 µM -0.607202695913798 0.300623070870513 no 2324 0.271858201677424 3492 4306703 SGTC_2834 9001755 58.44 µM -0.607719038641206 0.300473015649738 no 2325 0.271686916845844 3405 2989575 SGTC_2111 5486399 200 µM -0.608603804181125 0.300215971145972 no 2326 0.271393541165774 3544 689674 SGTC_2644 guaiazulene 100 µM -0.609160988110313 0.300054147582362 no 2327 0.271208867929693 3516 3515 A coloring agent. SGTC_3175 9106517 49.47 µM -0.609313321064275 0.300009912218694 no 2328 0.271158389549848 3510 41468073 SGTC_375 3970-0961 9.27 µM -0.609696328023388 0.299898705381345 no 2329 0.271031493714424 3467 2898222 SGTC_866 0495-0101 262 µM -0.609747376179413 0.299883884856307 no 2330 0.271014582947396 3436 635694 SGTC_690 glyoxal 20.3 µM -0.610668757782869 0.299616442314478 no 2331 0.270709446578283 3471 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1459 k035-0031 35.7 µM -0.610787003843259 0.299582127741546 no 2332 0.270670299143202 3470 3877128 YMR208W ERG12 SGTC_2036 5160441 105 µM -0.611029782624375 0.29951167981251 no 2333 0.270589931825627 3544 134534 YIL048W NEO1 SGTC_1552 6-methylflavone 10.6 µM -0.612719836599376 0.299021479431924 no 2334 0.270030801969859 3517 689013 SGTC_1617 st002906 78 µM -0.612955111278624 0.298953266877961 no 2335 0.269953010618491 3567 5150859 SGTC_1118 chelidonine 707.474 nM -0.614619066169282 0.298471042803105 no 2336 0.269403160014741 3557 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_1470 k295-0292 231 µM -0.616582474473215 0.297902490978931 no 2337 0.26875507856309 3556 5045612 SGTC_1962 st076595 64.5 µM -0.616804315695747 0.297838282607824 no 2338 0.268681902525948 3544 279619 SGTC_524 r073-0010 27.8 µM -0.617592656991297 0.297610160989374 no 2339 0.268421943096758 3502 2772106 SGTC_939 1165-0479 45.3 µM -0.620152982925532 0.296869832423268 no 2340 0.267578536332033 3509 1377347 SGTC_490 phenamil 164 µM -0.620633211492138 0.296731066314795 no 2341 0.267420491327016 3487 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_3084 9116877 49.47 µM -0.62628160089383 0.29510115016789 no 2342 0.265565126167144 3500 27241325 SGTC_2356 9061756 188.97 µM -0.62654253668783 0.295025953489958 no 2343 0.265479572847583 3520 20104043 SGTC_860 0443-0016 25.1 µM -0.626752163628563 0.294965549431563 no 2344 0.265410852351732 3572 5337942 SGTC_2121 5257820 149.641 µM -0.626867400667498 0.294932346275739 no 2345 0.265373078865651 3590 791256 SGTC_158 k038-0087 26.446 µM -0.62698908381183 0.294897287678346 no 2346 0.265333195376019 3513 X158 SGTC_666 0272-0154 136 µM -0.629879726083174 0.294065018992838 no 2347 0.264386639170746 3556 6870312 SGTC_1472 k841-0093 193 µM -0.631074349389533 0.293721382479677 no 2348 0.263995955981729 3627 X1472 SGTC_295 k015-0027 31 µM -0.631975739348604 0.29346221838147 no 2349 0.263701365122284 3542 3887424 SGTC_412 gemfibrozil 100 µM -0.632506538617107 0.29330965463143 no 2350 0.263527968609177 3560 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_559 1550-0661 158 µM -0.632663261632606 0.293264615911721 no 2351 0.263476782936978 3566 5830875 SGTC_2352 9027995 87.8 µM -0.633699100153132 0.292967019532545 no 2352 0.263138606156289 3513 2997347 SGTC_529 4076-0302 30.3 µM -0.633830214208777 0.292929360461223 no 2353 0.263095816335417 3534 5816522 SGTC_3217 9129673 49.47 µM -0.634022959596358 0.292874003486424 no 2354 0.263032919233406 3575 17248312 SGTC_1263 0774-1208 64.8 µM -0.638774430748237 0.291510906586125 no 2355 0.261484842189706 3623 906585 SGTC_225 nsc-122657 1.016 µM -0.638962987647132 0.291456874678089 no 2356 0.261423505102938 3529 275685 SGTC_2237 6667747 47.222 µM -0.639356922434726 0.291344005802485 no 2357 0.261295382951011 3477 729940 YDL015C TSC13 SGTC_2514 salinomycin 42.74 µM -0.641202538482069 0.290815477909247 no 2358 0.260695550289897 3623 23682228 A polyether potassium ionophore. SGTC_709 3807-1509 243 µM -0.642846693663953 0.2903450200995 no 2359 0.260161790684308 3624 1886677 YPL242C IQG1 SGTC_2836 9010338 19.48 µM -0.643244754756681 0.290231172690257 no 2360 0.260032648622334 3492 2994051 SGTC_538 2922-0838 53.3 µM -0.643889722927198 0.290046753060483 no 2361 0.25982347324445 3617 777039 SGTC_1023 4482-3888 16 µM -0.644671220931356 0.289823368265342 no 2362 0.259570135036925 3602 3303168 SGTC_3159 9100096 49.47 µM -0.644756076130459 0.28979911796082 no 2363 0.259542635205184 3555 25236875 SGTC_156 3474-0145 5.642 µM -0.6448588370274 0.289769751759099 no 2364 0.25950933451779 3559 2265471 SGTC_272 doxorubicin 8.13 µM -0.644914250245072 0.289753916784618 no 2365 0.259491378231028 3605 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1840 st055363 71 µM -0.645720574296271 0.289523546218 no 2366 0.259230166873117 3528 676033 SGTC_345 1362-0200 395 µM -0.647040429958503 0.289146642991911 no 2367 0.258802888721292 3538 1419823 SGTC_2899 9053889 58.44 µM -0.648500901537079 0.288729854011692 no 2368 0.2583305139587 3561 6470052 SGTC_2377 9073351 62.6 µM -0.652347445186921 0.287633484294763 no 2369 0.257088529711207 3557 7337946 YHR072W ERG7 SGTC_2936 9038235 15.59 µM -0.652749111459205 0.287519112023446 no 2370 0.256959017728094 3606 4749415 SGTC_639 0833-0042 114 µM -0.652828801436016 0.287496423295529 no 2371 0.256933326783683 3582 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_1757 st041620 31.8375 µM -0.653321410331139 0.287356190209492 no 2372 0.256774546170671 3599 5289815 SGTC_3305 9127027 53.8275 µM -0.653912096613343 0.287188079691313 no 2373 0.256584220039726 3543 41905295 SGTC_2702 st077768 96.8 µM -0.657584035920688 0.286144083911196 no 2374 0.255402727707821 3540 6484119 SGTC_1368 1852-0141 284 µM -0.658424395900328 0.285905408805092 no 2375 0.25513273174044 3588 2838987 SGTC_2188 6126565 140.678 µM -0.658618538630385 0.285850282757417 no 2376 0.255070377616297 3567 874518 SGTC_1059 3448-6867 171 µM -0.659714490937163 0.285539186339054 no 2377 0.254718532825812 3594 3934407 SGTC_704 1310-0270 142 µM -0.659717624683354 0.285538297026701 no 2378 0.254717527131678 3592 5718033 SGTC_2887 9044784 58.44 µM -0.662544466350241 0.284736617298902 no 2379 0.253811173548466 3627 6465546 SGTC_3071 9117417 49.47 µM -0.663546880183614 0.284452595428685 no 2380 0.253490182619309 3544 45595590 YGL055W OLE1 SGTC_751 0833-0568 350 µM -0.665752766423475 0.283828061234197 no 2381 0.252784570070042 3641 6954252 SGTC_183 3914-0051 30.55 µM -0.665907838876599 0.283784181569746 no 2382 0.252735004872872 3607 1596232 SGTC_798 1287-0182 476 µM -0.666487463711008 0.283620198335234 no 2383 0.252549786993074 3654 1649755 SGTC_1547 harmine 94.2 µM -0.666687504980531 0.283563614655542 no 2384 0.252485880835359 3661 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1706 st031321 9.9705 µM -0.666824666166897 0.283524820364252 no 2385 0.252442067580034 3633 6103185 SGTC_39 0986-0283 58.349 µM -0.667957889983226 0.283204399820613 no 2386 0.252080236431422 3662 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1611 st001856 99.4 µM -0.66839986501008 0.283079477898339 no 2387 0.251939190818174 3583 647478 SGTC_3129 9127257 49.47 µM -0.668699393182128 0.282994832868864 no 2388 0.251843627347781 3528 837894 SGTC_408 cantharidin 100 µM -0.669344166360426 0.282812664721368 no 2389 0.2516379795513 3594 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1043 0916-0009 19.3 µM -0.669812744983095 0.282680312277772 no 2390 0.251488583967445 3657 3101130 SGTC_918 glabranin 770.725 nM -0.670842788499223 0.282389475861328 no 2391 0.251160342961098 3647 124049 Also referred to as licorice root. SGTC_251 melphalan 456.522 µM -0.671208278164726 0.282286313174377 no 2392 0.251043927909712 3680 460612 A DNA alkylator. SGTC_2829 7992743 58.44 µM -0.671507749016288 0.282201798400057 no 2393 0.250948562325327 3605 16462845 SGTC_125 0133-0007 11.75 µM -0.671912110635838 0.282087701343035 no 2394 0.250819825021498 3696 26541 SGTC_3200 9114385 49.47 µM -0.673255521308556 0.281708796234361 no 2395 0.25039237222351 3621 17018030 YLR208W SEC13 SGTC_2825 7998094 58.44 µM -0.674451932236913 0.281371558675097 no 2396 0.250012017814721 3606 2987815 SGTC_1815 st051655 58.2 µM -0.674490759476595 0.281360617537012 no 2397 0.249999679274407 3608 5984156 SGTC_3209 9113616 49.47 µM -0.678045409607009 0.28035982266904 no 2398 0.24887145093378 3664 16649353 SGTC_2063 5246145 200 µM -0.67862636660048 0.280196421018281 no 2399 0.248687316077596 3669 711240 SGTC_2663 amphotericin b 100 µM -0.680474500061154 0.279676916711754 no 2400 0.248102031338067 3633 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3313 9133968 57.047 µM -0.681498616061693 0.279389242459008 no 2401 0.247778021079288 3632 1494643 SGTC_1733 st037357 54.9 µM -0.681670129016133 0.279341078514333 no 2402 0.247723779832084 3615 1272339 YGL099W LSG1 SGTC_638 3970-0837 4.09 µM -0.682641231047994 0.279068451577334 no 2403 0.247416786876355 3638 4118451 YLR208W SEC13 SGTC_1200 1643-0193 18.4 µM -0.682845692335113 0.279011067660409 no 2404 0.247352176772748 3647 5403974 SGTC_996 3970-0799 1.8 µM -0.683430978427263 0.278846833538137 no 2405 0.247167275274635 3713 6615648 YGL040C HEM2 SGTC_702 1488-0190 94 µM -0.683789412992593 0.278746278288724 no 2406 0.247054076410226 3650 949357 SGTC_970 1315-0089 19.5 µM -0.684750546153374 0.278476729104728 no 2407 0.246750673485096 3605 6811083 YLR033W RSC58 SGTC_1891 st059073 26.2 µM -0.685402959743586 0.278293832514635 no 2408 0.246544838443243 3686 688754 SGTC_439 amiodarone 34.4 µM -0.685937887957109 0.278143915291817 no 2409 0.246376138432545 3582 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_688 0527-0193 473 µM -0.68766886808119 0.277659066619864 no 2410 0.245830664491377 3673 4007154 SGTC_86 0417-1630 471.922 µM -0.687872207614633 0.277602138191885 no 2411 0.245766629833257 3696 3634867 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.689065445819031 0.27726818543551 no 2412 0.245391041816156 3667 115019 SGTC_2000 st075254 36.4 µM -0.692656412853672 0.276264364989997 no 2413 0.244262599377175 3638 17234175 SGTC_618 k072-0232 33.2 µM -0.692820885996619 0.276218430840417 no 2414 0.244210981640878 3649 5872756 YGL099W LSG1 SGTC_394 menadione 8.33 µM -0.694016907708695 0.275884518010378 no 2415 0.243835802867698 3627 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.694028917980161 0.275881165913523 no 2416 0.243832036956673 3710 688788 SGTC_1619 st003326 88.7 µM -0.694434785300077 0.275767899092483 no 2417 0.2437047926594 3629 2849032 SGTC_1603 st002045 67.8 µM -0.694925876728565 0.275630879043086 no 2418 0.243550877521237 3668 5887985 SGTC_2581 avocatin a 64 µM -0.696154509501537 0.275288223336117 no 2419 0.243166036384363 3680 6710728 A skin care supplement. SGTC_2020 4017018 200 µM -0.696265019966162 0.27525741314514 no 2420 0.243131437630454 3709 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2014 4013930 200 µM -0.696726714955645 0.275128711473133 no 2421 0.242986918383924 3653 64556 SGTC_3126 9127922 49.47 µM -0.699264662116284 0.274421765284424 no 2422 0.242193323453935 3697 45595682 SGTC_3257 9139206 32.98 µM -0.702848925448802 0.273424896935642 no 2423 0.241074951687669 3663 4910041 SGTC_389 tpck 16.7 µM -0.704311170627956 0.273018727531486 no 2424 0.240619505619977 3678 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_2860 9025725 38.96 µM -0.705319440774417 0.272738833593962 no 2425 0.240305732381968 3676 40546248 SGTC_2597 laccaic acid a 100 µM -0.706000235688522 0.27254992673278 no 2426 0.24009399544089 3668 5491415 A textile dye. SGTC_155 k072-0202 43.6 µM -0.70696973191251 0.272281023247743 no 2427 0.239792643894673 3621 5857737 SGTC_2281 7943571 200 µM -0.707813301739965 0.272047154532588 no 2428 0.239530602429699 3764 1244024 SGTC_216 k038-0035 28.382 µM -0.707909940502871 0.272020369076118 no 2429 0.239500593128838 3616 4444231 YPR107C YTH1 SGTC_801 0866-0028 10.1 µM -0.708360927761421 0.271895385858829 no 2430 0.239360574895314 3708 6849771 SGTC_2681 menadione 3.18 µM -0.708977642755564 0.27172452036007 no 2431 0.239169175489195 3713 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_686 1319-0111 510 µM -0.709112806910703 0.271687079262314 no 2432 0.239127238052521 3729 4562600 SGTC_2319 6033012 152.6 µM -0.709824733007575 0.271489914829702 no 2433 0.238906414804672 3669 847246 SGTC_2997 9067075 71.4286 µM -0.710528431133951 0.271295099158684 no 2434 0.238688253322138 3711 27209819 SGTC_2170 morpholine 200 µM -0.712579668881675 0.270727621046541 no 2435 0.238052948151894 3715 121171 Reacts with secondary amines. SGTC_998 3996-0085 177 µM -0.71314057587956 0.270572548507015 no 2436 0.237879386687911 3730 715391 SGTC_3058 9093861 49.47 µM -0.71390931717603 0.270360088647489 no 2437 0.237641627813485 3705 17217477 SGTC_2711 st079103 59.1 µM -0.716825430479986 0.269554910591233 no 2438 0.236740909111548 3693 54693780 SGTC_2803 7707263 71.43 µM -0.718781281323668 0.2690155479548 no 2439 0.236137846422923 3703 2199229 SGTC_805 3852-0218 479 µM -0.720568439202518 0.268523179657059 no 2440 0.235587538869382 3670 6615355 SGTC_1994 st072947 40.9 µM -0.721575929120728 0.268245812441193 no 2441 0.235277621352923 3738 5286565 YDL195W SEC31 SGTC_809 3998-0021 90 µM -0.721723245029974 0.268205267687655 no 2442 0.235232323858215 3640 715485 SGTC_2755 lomerizine 42.69 µM -0.722373793107857 0.268026258657974 no 2443 0.235032347403988 3715 3949 A calcium channel blocker. SGTC_920 mycophenolic acid 780.421 nM -0.722648555864112 0.267950671227025 no 2444 0.234947914406774 3738 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2239 6685329 187.64 µM -0.724135909969535 0.267541685467532 no 2445 0.234491150193179 3741 805680 SGTC_2962 9082311 13.18 µM -0.72491972990025 0.267326280995982 no 2446 0.234250638072175 3707 16459453 SGTC_1050 3232-1156 69.3 µM -0.72541721398049 0.267189610950741 no 2447 0.234098057871766 3698 700529 SGTC_79 0052-0007 94.094 µM -0.72650974322686 0.26688959246182 no 2448 0.233763168362651 3737 2801472 SGTC_136 0097-0015 404.482 µM -0.726953783350107 0.266767703657791 no 2449 0.23362713408969 3723 4861337 SGTC_414 piperonyl butoxide 100 µM -0.72852218818861 0.2663374025692 no 2450 0.233146995646311 3701 5794 A potent inhibitor of cytochrome P450. SGTC_1724 st037281 8.293 µM -0.728921242287972 0.266227975809801 no 2451 0.233024920014 3740 574124 YDL195W SEC31 SGTC_1399 3562-5772 25 µM -0.729388762945474 0.266099803426466 no 2452 0.232881944771124 3674 23847490 SGTC_429 1112-0049 25.5 µM -0.731814783897907 0.265435203689504 no 2453 0.232140812136863 3703 2836170 SGTC_2384 9036245 200 µM -0.73255876555138 0.265231561468359 no 2454 0.231913794185608 3724 6462766 SGTC_817 1391-0715 46 µM -0.733188093297036 0.265059364199728 no 2455 0.231721858200286 3715 1353946 SGTC_543 3844-1095 191 µM -0.734174872545123 0.264789475091196 no 2456 0.231421082879394 3739 4230703 SGTC_2923 7992654 58.14 µM -0.737309425019013 0.263933086953523 no 2457 0.230467100963108 3764 2985126 SGTC_1959 st077091 55.8 µM -0.737442220317458 0.263896837271569 no 2458 0.230426734119402 3743 821356 YKL052C ASK1 SGTC_1326 1431-2094 10.8 µM -0.738805450402897 0.263524857532189 no 2459 0.230012570853181 3717 616278 SGTC_2476 5806916 10.51 µM -0.739292192308532 0.263392106858701 no 2460 0.229864794663568 3656 2870194 SGTC_315 k915-0449 187 µM -0.739750659327331 0.263267098916978 no 2461 0.229725651431448 3780 20970215 YNL149C PGA2 SGTC_2095 5432005 200 µM -0.739823314167 0.263247291261894 no 2462 0.229703605257322 3743 783734 SGTC_1936 st074407 74.3 µM -0.741380312290718 0.262822994894294 no 2463 0.229231439140975 3780 809813 SGTC_88 0180-0332 8.668 µM -0.741467521406919 0.262799239952076 no 2464 0.229205008720871 3802 3101745 SGTC_1829 berberine 14.4 µM -0.742419210911578 0.262540080086663 no 2465 0.228916691798053 3757 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3118 9124250 49.47 µM -0.742996825481526 0.262382850463207 no 2466 0.22874180119157 3700 1504786 SGTC_1878 temozolomide 1 mM -0.744391703918117 0.262003356375796 no 2467 0.228319768238378 3674 5394 DNA alkylating agent. SGTC_505 gw-5074 63.9 µM -0.744709165367943 0.261917026350454 no 2468 0.228223778606617 3787 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_175 3793-3120 23.7 µM -0.746122524174627 0.261532856628017 no 2469 0.227796702034913 3754 5322297 SGTC_3150 9097574 49.47 µM -0.748450551287016 0.260900699151526 no 2470 0.227094220414787 3721 17217476 SGTC_464 bw-b 70c 158 µM -0.748450946987455 0.260900591769019 no 2471 0.227094101116179 3802 5353454 SGTC_2249 haloperidol 116.36 µM -0.748949153942818 0.260765409771394 no 2472 0.226943926136836 3746 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_1123 mangostin 811.285 nM -0.749797826725627 0.260535216427056 no 2473 0.226688238933145 3773 5281650 An antioxidant. SGTC_1737 st035557 69.7 µM -0.750834230089063 0.260254245154484 no 2474 0.226376213072835 3672 5716916 SGTC_393 acivicin 6.25 µM -0.75102491616293 0.260202566744983 no 2475 0.22631883040304 3648 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_427 1354-0053 47.3 µM -0.751496414398304 0.260074807292044 no 2476 0.226176978932418 3854 6813657 SGTC_743 1275-0778 158 µM -0.752831927798248 0.259713105714224 no 2477 0.225775459058821 3772 2849257 YMR203W TOM40 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.754881188523233 0.259158602819862 no 2478 0.225160136927618 3782 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_3213 9129884 49.47 µM -0.754994771499685 0.259127886677 no 2479 0.225126059697267 3748 17190742 SGTC_3065 9113888 49.47 µM -0.755201980520868 0.259071856175679 no 2480 0.225063900254889 3796 16648368 SGTC_92 0063-0024 660.874 µM -0.75553718185491 0.258981229088905 no 2481 0.224963365728855 3837 3594437 SGTC_1983 st071813 46.9 µM -0.75914346510631 0.258007250443827 no 2482 0.223883370390645 3825 11838595 SGTC_1967 st070177 51.4 µM -0.762300617584588 0.257156134635431 no 2483 0.222940302696886 3816 5729214 SGTC_1431 4049-0260 9.09 µM -0.762445194299751 0.257117194144184 no 2484 0.222897170682695 3749 3854841 SGTC_2738 aclarubicin 5.55 µM -0.762573469907466 0.257082646783098 no 2485 0.222858905808208 3709 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_201 4262-0159 12.803 µM -0.765328842102647 0.256341149477743 no 2486 0.222037876783886 3779 1341029 SGTC_361 000s-0510 1.45 µM -0.765853549402678 0.256200072118464 no 2487 0.221881723657391 3787 660 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.766474863827937 0.256033072492891 no 2488 0.221696901335925 3854 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2015 5119600 184 µM -0.766633810789148 0.255990359152571 no 2489 0.221649633537955 3787 2828786 SGTC_1022 4477-0945 21.3 µM -0.766754285501794 0.255957986821203 no 2490 0.221613810490779 3748 4648966 SGTC_2044 5102272 200 µM -0.767097785502669 0.255865697886811 no 2491 0.221511689243412 3772 592666 SGTC_2693 st077581 40.7 µM -0.768170817233888 0.255577515885326 no 2492 0.221192854299589 3841 25238761 SGTC_2948 9070189 9.45 µM -0.768355038223478 0.255528057077475 no 2493 0.221138142271867 3685 6473636 YDL196W YDL196W SGTC_786 4544-0069 423 µM -0.770407420299476 0.254977381269839 no 2494 0.220529126574485 3831 748821 YLR208W SEC13 SGTC_928 2764-0428 58.7 µM -0.770922912827838 0.254839166804974 no 2495 0.220376312516929 3843 662578 SGTC_2837 9008476 45.46 µM -0.771278956430007 0.254743726876626 no 2496 0.220270801397972 3774 2992805 SGTC_2306 7482397 179.52 µM -0.772941951704615 0.254298197557037 no 2497 0.219778367723056 3774 891448 SGTC_1423 4048-0112 5.59 µM -0.77345353787646 0.254161221864646 no 2498 0.219627007871247 3808 X1423 SGTC_3174 9107204 49.47 µM -0.775239723278886 0.253683279545726 no 2499 0.219099009802394 3808 3938802 SGTC_1195 1502-0147 41.1 µM -0.775689571151927 0.253562985001232 no 2500 0.218966149499824 3782 817940 SGTC_1798 st045719 60.953 µM -0.776220367741294 0.253421082380244 no 2501 0.218809441017042 3712 3980186 SGTC_1468 k284-1086 134 µM -0.778743622905643 0.252747089098123 no 2502 0.218065376822449 3790 15996457 SGTC_1721 st082152 9.2685 µM -0.779481318557212 0.252550219747979 no 2503 0.217848119019556 3740 5296051 SGTC_2759 disulfiram 3.38 µM -0.77960641982756 0.25251684189904 no 2504 0.217811287988811 3756 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_958 1222-0007 33 µM -0.780160511256676 0.252369034579894 no 2505 0.217648201272785 3868 7312461 SGTC_1226 3909-7979 35.4 µM -0.780170630401034 0.252366335659588 no 2506 0.217645223542328 3814 6615510 SGTC_2017 5132927 60.65 µM -0.780545263140438 0.252266426467409 no 2507 0.217534998029206 3821 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_2004 4023728 41.89 µM -0.781424555774591 0.252032013643358 no 2508 0.217276416639229 3811 360084 YDR527W RBA50 SGTC_1020 4335-0961 93.3 µM -0.783164702119613 0.251568442672786 no 2509 0.216765199990942 3759 669075 SGTC_1397 3532-0190 20.1 µM -0.784027783257936 0.251338687079885 no 2510 0.216511904026585 3721 5322280 SGTC_3096 9117468 49.47 µM -0.785630048824361 0.250912451980565 no 2511 0.21604212750404 3756 41316311 SGTC_1469 k284-2957 126 µM -0.790173514453664 0.249705881726431 no 2512 0.214713220760077 3809 23884841 SGTC_3297 9117502 71.43 µM -0.792631690786351 0.249054371173799 no 2513 0.213996219671509 3830 7453720 SGTC_2969 9091408 28.7 µM -0.793455347387453 0.248836273192428 no 2514 0.213756287529547 3780 4286311 SGTC_2763 lisinopril 49.32 µM -0.795433210985407 0.248312965501471 no 2515 0.213180773790834 3745 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_3160 9100216 49.47 µM -0.795809220669166 0.248213546410483 no 2516 0.213071465767083 3732 17191039 SGTC_3299 9121982 43.1275 µM -0.796422142526764 0.248051531911214 no 2517 0.212893356214618 3894 17594604 YPL160W CDC60 SGTC_3347 9188721 44.724 µM -0.796877802414335 0.247931123262412 no 2518 0.212761001897784 3870 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2470 5664817 21.68 µM -0.797666463478791 0.247722792409639 no 2519 0.212532035173815 3853 2859561 SGTC_2104 5389443 200 µM -0.798518006042483 0.247497955925926 no 2520 0.212284974157976 3881 2244536 SGTC_1708 st033234 31.827 µM -0.802989301887406 0.246319171813837 no 2521 0.210990459005324 3918 674664 SGTC_2415 st077333 57.7 µM -0.80378736670781 0.246109092035981 no 2522 0.210759893531761 3823 2766255 SGTC_580 1123-0028 41 µM -0.805515368063864 0.245654548546097 no 2523 0.210261170823946 3910 1677248 YPR107C YTH1 SGTC_952 1185-0122 232 µM -0.805567570774882 0.245640823861656 no 2524 0.210246115263828 3781 678600 SGTC_2855 9016525 58.44 µM -0.806165028683238 0.245483774737036 no 2525 0.210073850081005 3814 43811474 SGTC_2214 7179297 48.276 µM -0.806353031927369 0.245434366944164 no 2526 0.210019660217378 3853 769744 SGTC_3340 9146634 11.102 µM -0.809125564271206 0.244706358336907 no 2527 0.20922146248337 3873 4907387 SGTC_1874 staurosporine 7.6 µM -0.813873909939991 0.243462248355469 no 2528 0.207858594199023 3912 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_1236 0330-0013 258 µM -0.816964402893146 0.242654350414004 no 2529 0.206974385586293 3866 4617066 SGTC_651 3253-0966 34.4 µM -0.817762299035074 0.242446005234793 no 2530 0.206746464723598 3879 781462 SGTC_360 0957-0399 1.01 µM -0.819823172728442 0.241908322360925 no 2531 0.206158459441412 3886 6752301 YPR165W RHO1 SGTC_3177 9107506 49.47 µM -0.820558446742927 0.241716645730349 no 2532 0.20594891240832 3763 8897194 SGTC_3003 9075612 71.4286 µM -0.822775035975127 0.241139308147131 no 2533 0.205317967724183 3890 6501993 SGTC_1877 wortmannin 25 µM -0.824382447861056 0.240721107574242 no 2534 0.204861142397572 3875 312145 A covalent inhibitor of PI 3-kinase. SGTC_135 0933-0004 26.348 µM -0.824831230385832 0.240604418287881 no 2535 0.204733706731131 3862 21230617 YGL099W LSG1 SGTC_2839 9003951 25.97 µM -0.825290089854793 0.240485140711254 no 2536 0.204603458394118 3914 2990634 SGTC_1746 st038117 42 µM -0.826441527435578 0.240185973731489 no 2537 0.204276837290939 3940 2898218 SGTC_2435 5706476 10.6 µM -0.82794243057063 0.239796313181851 no 2538 0.203851551901539 3879 5725375 SGTC_2555 cholic acid 100 µM -0.828200233307112 0.239729417833823 no 2539 0.203778555867917 3891 6708657 Influences liver metabolism. SGTC_2362 9071156 126 µM -0.8334617870485 0.238366362902887 no 2540 0.202292170274114 3908 653133 SGTC_1951 sophoraflavanone G 9.2 µM -0.833867193860355 0.238261514859511 no 2541 0.20217791282131 3869 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_2869 9037858 32.47 µM -0.833927792766112 0.238245844682038 no 2542 0.202160837302517 3831 27187042 SGTC_904 1141-0088 396 µM -0.834790617382465 0.238022789456401 no 2543 0.201917804782722 3902 1378119 SGTC_245 methotrexate 289.6 µM -0.837991553355144 0.237196292550789 no 2544 0.201017723699109 3882 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3166 9102297 49.47 µM -0.838834808830273 0.236978822632557 no 2545 0.20078100722962 3909 25237072 SGTC_1006 4099-6547 255 µM -0.839753931348257 0.236741911991619 no 2546 0.2005231842132 3927 3146833 SGTC_719 2810-4230 27.3 µM -0.84029352345213 0.236602888834528 no 2547 0.200371915922045 3876 721079 SGTC_2814 7977482 42.97 µM -0.841131680474519 0.23638703104845 no 2548 0.200137084458805 3972 6456762 SGTC_1607 st000305 50.6 µM -0.841603359550728 0.236265603166996 no 2549 0.200005004083215 3896 5457690 SGTC_2983 9022671 12.99 µM -0.84247613586543 0.236041008424099 no 2550 0.199760746023983 3933 6405161 SGTC_1752 st044819 83.042 µM -0.842851865992912 0.235944356641582 no 2551 0.19965564822921 3904 441209 YML126C ERG13 SGTC_1453 4237-0541 195 µM -0.843492321685654 0.235779657873322 no 2552 0.199476579120262 3819 739892 SGTC_1258 0671-0043 57.1 µM -0.846961914399884 0.234888524647376 no 2553 0.198508175100835 3938 4298767 SGTC_2344 7990960 76.95 µM -0.847276926945672 0.234807708823474 no 2554 0.198420392064398 3877 140813 SGTC_1377 2944-0135 198 µM -0.847458337529583 0.234761175284739 no 2555 0.198369849876269 3954 1894137 SGTC_1334 1486-0610 236 µM -0.847975993547272 0.234628419631049 no 2556 0.19822567020623 3977 3742339 SGTC_2799 7812892 81.82 µM -0.848971218925477 0.234373305439317 no 2557 0.197948653740562 3923 20205235 SGTC_1227 3909-8010 46.6 µM -0.849974528307862 0.234116274465865 no 2558 0.197669623944783 3895 15982272 SGTC_2941 9056145 11.23 µM -0.851959087681934 0.233608323811515 no 2559 0.197118399890797 3762 2119517 SGTC_451 chloral hydrate 100 µM -0.852219373866869 0.233541748570425 no 2560 0.197046172801439 3971 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2425 5628681 7.85 µM -0.852285633380335 0.233524802585737 no 2561 0.197027788936842 3975 5714958 SGTC_2368 9071271 200 µM -0.852438891677393 0.233485609125347 no 2562 0.196985271023937 3917 27209959 SGTC_1594 piperine 70.1 µM -0.853391143858996 0.233242167007849 no 2563 0.196721215515814 3890 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1557 sumaresinolic acid 42.3 µM -0.854325691087971 0.23300338817465 no 2564 0.196462278066703 3875 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2713 st079149 53.4 µM -0.855546522740885 0.232691667662385 no 2565 0.196124330361616 3949 3103253 SGTC_705 1124-0212 310 µM -0.857593817994702 0.232169443085615 no 2566 0.19555839492365 3852 9554485 SGTC_2354 9060492 162 µM -0.857672174539591 0.232149468847568 no 2567 0.195536754483619 3982 6471895 SGTC_1191 1487-1166 10.6 µM -0.857926664894739 0.2320846021038 no 2568 0.195466479598514 3959 3955771 SGTC_2420 aureobasidin a 50 nM -0.85865302563385 0.231899516386489 no 2569 0.195265986964294 4062 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_771 0250-0039 27.3 µM -0.860981789141988 0.231306673212634 no 2570 0.194624036499319 3879 3005115 SGTC_2037 5169046 200 µM -0.86113558084319 0.231267551588739 no 2571 0.194581687299168 3982 5718022 SGTC_3039 9090270 49.47 µM -0.861935880226999 0.231064030549364 no 2572 0.194361401577221 3894 17173750 SGTC_2980 9014342 25.29 µM -0.86313590659834 0.230759043896938 no 2573 0.194031374012849 3989 2996599 SGTC_2272 7805186 180 µM -0.864997948754196 0.230286251408471 no 2574 0.193519957321884 3942 2956062 YPR165W RHO1 SGTC_3024 9090631 49.47 µM -0.865341697737402 0.230199029124788 no 2575 0.193425635389358 3872 25236383 SGTC_945 3381-0768 11.3 µM -0.865602478126241 0.230132871480354 no 2576 0.193354098079511 3980 1126236 YIL048W NEO1 SGTC_861 0443-0273 110 µM -0.866113048978174 0.230003375042184 no 2577 0.193214084971344 3949 6149169 SGTC_2236 dapsone 200 µM -0.866965341570684 0.229787298364515 no 2578 0.192980499919831 3925 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_972 1319-0219 195 µM -0.868955590059668 0.229283165381402 no 2579 0.1924357109438 3906 23903702 SGTC_713 1488-1073 324 µM -0.869464365577003 0.229154391358411 no 2580 0.192296595326879 3872 3312542 SGTC_2412 st077135 33.4 µM -0.869709334754352 0.229092402714289 no 2581 0.192229634805198 4037 13258915 SGTC_1101 ebselen 5.29 µM -0.871276926188758 0.228695951616617 no 2582 0.191801482965182 3990 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2747 doxorubicin 7.63 µM -0.871364753333674 0.228673751128883 no 2583 0.191777512269183 3835 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2898 9056270 58.44 µM -0.872680396049619 0.228341334700457 no 2584 0.191418652984595 3873 19154699 SGTC_1806 st050005 60.3 µM -0.873346944708009 0.228173025107654 no 2585 0.191237000003298 3951 5194765 SGTC_2134 5324836 1.464 µM -0.874322249280183 0.227926877588157 no 2586 0.19097139299341 3904 699272 SGTC_2687 chenodiol 100 µM -0.874893525822229 0.227782768132467 no 2587 0.190815921034105 4006 5702181 A cholesterol synthesis inhibitor. SGTC_1602 st001878 87.6 µM -0.875031499674813 0.227747970722668 no 2588 0.19077838332663 3948 595405 YLR310C CDC25 SGTC_2141 5621638 7.665 µM -0.875869835443133 0.227536604317148 no 2589 0.190550399834656 3973 2856238 SGTC_12 0849-0099 9.267 µM -0.875977440494739 0.227509482266995 no 2590 0.190521149004592 3835 6071388 SGTC_1514 1189-1591 158 µM -0.878552613427052 0.226860948636954 no 2591 0.189821949295426 3991 767698 YMR146C TIF34 SGTC_487 nimodipine 119 µM -0.879085340012169 0.226726916643652 no 2592 0.189677502912509 3843 4497 L-type voltage-gated calcium channels inhibitor SGTC_1312 1218-2183 165 µM -0.880344415351972 0.226410315725671 no 2593 0.189336379204324 3938 6744073 SGTC_2816 7982706 58.44 µM -0.880611754949423 0.2263431239686 no 2594 0.189263997006142 4007 2981853 SGTC_2409 alverine citrate 63.97 µM -0.881378858095203 0.226150386754765 no 2595 0.189056398414332 4138 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_973 1325-0077 65.9 µM -0.882024670837746 0.225988196090826 no 2596 0.188881733030399 3957 2835149 SGTC_1740 st038286 13.222 µM -0.88575384115024 0.225052932251206 no 2597 0.187875094085458 4014 716786 SGTC_2431 5490079 200 µM -0.885861634452651 0.225025930695366 no 2598 0.187846046094603 4010 5722345 SGTC_1651 st011928 86.1 µM -0.885920031420236 0.225011303382741 no 2599 0.187830310518442 3970 720198 SGTC_2910 7948405 25.97 µM -0.886221240433073 0.224935864899913 no 2600 0.187749160031161 3847 2971328 SGTC_621 3584-0052 32.1 µM -0.886551313976371 0.224853213694594 no 2601 0.187660257853511 3934 2273927 SGTC_779 1360-0071 233 µM -0.887400068198856 0.224640762683972 no 2602 0.187431773398848 4023 7566 SGTC_2116 5511452 16.8835 µM -0.889994402041613 0.223992083403214 no 2603 0.18673444596624 4007 870744 SGTC_3185 9108267 49.47 µM -0.891472193528237 0.223623057217994 no 2604 0.186337951312402 3943 4910486 SGTC_492 tmb-8 126 µM -0.8922887181453 0.223419307436245 no 2605 0.186119099871232 3889 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_3106 9121286 49.47 µM -0.893032495412834 0.223233802474639 no 2606 0.18591988547733 3988 15943471 SGTC_1128 3448-9350 235 µM -0.893282042078047 0.223171582865409 no 2607 0.185853076167099 4014 619386 SGTC_299 1273-0059 1.44 µM -0.893715822870727 0.223063451558334 no 2608 0.185736978637001 3852 2848077 SGTC_1677 st019204 53.9 µM -0.896346807128517 0.222408248910286 no 2609 0.185033783676604 3985 3945625 SGTC_3318 9139014 38.6185 µM -0.897869403592068 0.222029573707612 no 2610 0.184627589087691 3961 16643984 SGTC_765 1319-0117 244 µM -0.902037744738588 0.22099477762354 no 2611 0.183518408801693 3923 3487746 YGL099W LSG1 SGTC_1103 duloxetine 36.1 µM -0.902262315193176 0.220939106191526 no 2612 0.183458769569548 4061 60835 A selective serotonin reuptake inhibitor. SGTC_2414 st077232 92.9 µM -0.902564201203126 0.220864280741123 no 2613 0.18337861666499 3944 729801 SGTC_610 4215-0184 155 µM -0.902577232760192 0.220861051066782 no 2614 0.183375157184606 3986 5605015 SGTC_1012 4112-3522 18 µM -0.903140143319383 0.220721568010296 no 2615 0.183225760465809 3994 3112398 SGTC_1567 st069303 68.4 µM -0.90625617567302 0.219950362622862 no 2616 0.182400137836846 4056 5581319 SGTC_172 1112-0046 2.638 µM -0.906968796633956 0.219774209308512 no 2617 0.182211649142062 3942 2802135 YIL048W NEO1 SGTC_1968 st069590 43.6 µM -0.908023705439966 0.21951359434003 no 2618 0.181932848679455 3988 6384066 SGTC_1558 st069300 45.6 µM -0.908071845495955 0.21950170558765 no 2619 0.18192013217541 3899 24208000 SGTC_3032 9089427 49.47 µM -0.909171404226835 0.219230257366167 no 2620 0.181629828058069 4007 17173707 SGTC_1860 st056228 74.6 µM -0.910765353620314 0.218837101661392 no 2621 0.181209510576599 3975 688679 SGTC_780 0109-0199 192 µM -0.911247770054865 0.218718191217729 no 2622 0.181082419661098 4087 610414 SGTC_3093 9117344 49.47 µM -0.911874120547233 0.218563858081344 no 2623 0.180917493165749 4036 24824913 SGTC_1370 2001-0092 44.6 µM -0.912212541168386 0.218480497135003 no 2624 0.180828421657518 4046 790957 SGTC_1421 4029-0249 71.4 µM -0.913352876737694 0.218199740531251 no 2625 0.180528490438631 4050 2894095 SGTC_1179 1021-1431 9.29 µM -0.913437097089886 0.218179013286171 no 2626 0.180506351170503 4026 2840958 SGTC_52 0329-0193 875 nM -0.914363541585674 0.217951083418177 no 2627 0.180262926215848 4102 3739292 SGTC_484 loperamide 105 µM -0.915492142506698 0.217673603313246 no 2628 0.179966662792683 3966 3955 An opioid-receptor agonist. SGTC_567 1080-0542 68.4 µM -0.915512291782845 0.217668651224204 no 2629 0.179961376285941 3864 5950415 SGTC_670 4204-0025 119 µM -0.915526584638795 0.217665138507383 no 2630 0.179957626370186 3999 719039 SGTC_540 1187-0821 17.3 µM -0.915582223468118 0.217651464613229 no 2631 0.179943029270461 3943 847520 SGTC_2128 5255449 168.493 µM -0.916510857417048 0.217423315126407 no 2632 0.179699507714754 3986 736008 SGTC_2908 7930301 100 µM -0.916681601027936 0.217381381372343 no 2633 0.179654755084362 3969 2223178 SGTC_2744 captopril 92.04 µM -0.91726185305182 0.217238909360211 no 2634 0.179502720895304 3994 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2781 5567276 71.43 µM -0.917323685056962 0.217223730637264 no 2635 0.179486524809959 4047 2853274 SGTC_2074 5212007 75.395 µM -0.917814450088112 0.217103277760415 no 2636 0.179358007907806 3839 758611 SGTC_1482 3346-2049 8.48 µM -0.918416490762684 0.216955566223435 no 2637 0.179200430240155 3987 3826804 SGTC_3329 9141233 27.5565 µM -0.918915389767454 0.216833204666691 no 2638 0.1790699147928 3979 4909101 YNL103W MET4 SGTC_763 3453-1109 128 µM -0.922094315697444 0.216054468844474 no 2639 0.178239690852977 4027 1560353 SGTC_1650 st011916 45.8 µM -0.922247204681369 0.216017056777602 no 2640 0.178199822849913 3906 242528 SGTC_2851 9015922 71.43 µM -0.922535007717592 0.215946641307529 no 2641 0.178124789315881 4019 2996893 SGTC_1508 1080-0625 72.9 µM -0.922947612245113 0.215845714423171 no 2642 0.178017253358716 3883 767111 SGTC_2103 5378138 10 µM -0.923755667238992 0.21564813590843 no 2643 0.177806770871105 4035 244142 SGTC_768 0384-0033 77.3 µM -0.924478460418394 0.215471493746477 no 2644 0.177618630486253 3991 3965305 YMR134W ERG29 SGTC_2269 7935389 174.42 µM -0.92543751799805 0.215237240953005 no 2645 0.177369185365326 3952 97605 SGTC_1314 1222-0010 41.1 µM -0.925991634404557 0.21510196369518 no 2646 0.177225163877221 4008 3526027 SGTC_1385 3091-4834 14.1 µM -0.926119140926525 0.215070842326806 no 2647 0.177192033861456 3986 4072814 SGTC_3254 9136651 49.47 µM -0.926375974185822 0.215008163255014 no 2648 0.177125312759417 3989 16454030 SGTC_796 1234-0020 70.7 µM -0.927327502419442 0.214776039277479 no 2649 0.176878259547046 3932 46495034 SGTC_60 0986-0278 202 µM -0.927441489698868 0.214748242009895 no 2650 0.176848678693181 3952 3110598 SGTC_3260 9137109 49.47 µM -0.927569669914618 0.214716986109015 no 2651 0.176815418363842 3942 17478346 SGTC_226 1,3-diallylurea 8.28947 mM -0.928361720092093 0.214523908537141 no 2652 0.176609984111497 3967 74537 YKL182W FAS1 SGTC_1499 4480-0877 67.3 µM -0.928385921969184 0.214518010450493 no 2653 0.176603709242004 3928 2861909 SGTC_1433 4060-0023 7.6 µM -0.928732601447321 0.214433533731978 no 2654 0.176513840428987 4016 3840627 SGTC_937 3122-0005 46.7 µM -0.929351391347905 0.214282798910606 no 2655 0.176353505048948 4050 759535 SGTC_2971 9092186 9.93 µM -0.932173460271918 0.213596135852149 no 2656 0.175623444385198 4032 25236400 SGTC_2819 7996655 46.38 µM -0.932608132193151 0.213490485964035 no 2657 0.17551116652318 3965 6456960 SGTC_532 1548-0774 215 µM -0.933322682038742 0.213316876092038 no 2658 0.175326693728844 4143 5932993 SGTC_935 2996-0153 430 µM -0.933422829379095 0.213292550474333 no 2659 0.175300848871956 4035 23738523 SGTC_3002 9075603 71.4286 µM -0.933467133041645 0.213281789706514 no 2660 0.17528941627051 3959 20105405 SGTC_1076 itraconazole 331 nM -0.935542055916877 0.212778173334359 no 2661 0.174754510132289 4012 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1649 st011737 51.3 µM -0.936564811814285 0.212530190058648 no 2662 0.174491229746779 4000 1761035 SGTC_3128 9127691 49.47 µM -0.938254166838885 0.212120949257356 no 2663 0.174056903805126 4079 41316314 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.9398168388433 0.211742807543351 no 2664 0.173655759961469 4020 77254 SGTC_1767 st044992 70.3 µM -0.940883268458895 0.211484975199069 no 2665 0.173382341379108 4075 9600693 SGTC_2866 9034245 58.44 µM -0.942970280470711 0.210980927329281 no 2666 0.172848052275649 3985 6462273 SGTC_1774 st048371 48.465 µM -0.945898242817601 0.210274964508588 no 2667 0.172100244914491 4001 4242727 SGTC_128 0906-2981 13.371 µM -0.947229834943923 0.209954362931386 no 2668 0.171760837800865 3967 6740226 SGTC_3337 9144342 33.5465 µM -0.947710985276845 0.20983858917127 no 2669 0.171638303482517 4030 17682949 SGTC_358 0075-0058 9.45 µM -0.947736122375246 0.209832541747392 no 2670 0.171631903365473 3876 1069125 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.948126076006548 0.209738740744924 no 2671 0.171532637414703 4069 521171 SGTC_2200 6600604 21.907 µM -0.95006780037028 0.209272037777165 no 2672 0.171038901565125 3997 2904777 SGTC_558 k064-0027 21.3 µM -0.950629025843995 0.20913725843982 no 2673 0.170896364346195 4043 5088526 SGTC_859 0439-0102 54.6 µM -0.954181083356472 0.208285411365011 no 2674 0.169995994139529 4041 610143 SGTC_1988 st071872 53.4 µM -0.954631675445639 0.208177497798793 no 2675 0.16988199645134 4066 16414116 SGTC_989 1501-0895 10.3 µM -0.956324118138865 0.207772464737793 no 2676 0.169454254286378 3996 2830112 SGTC_716 1683-5115 658 µM -0.956368987448725 0.207761733013682 no 2677 0.169442923583146 3980 723597 SGTC_3235 9132602 49.47 µM -0.956529907417525 0.207723247289556 no 2678 0.16940229097717 4049 4912240 SGTC_1687 st020778 55.3625 µM -0.956972801122108 0.207617346291952 no 2679 0.169290491745772 4054 4259299 SGTC_953 1188-0045 9.7 µM -0.957589584888954 0.20746991933319 no 2680 0.169134876540413 4073 6144426 SGTC_1866 st057638 64 µM -0.959014066487781 0.207129668683355 no 2681 0.168775829467738 4016 688802 SGTC_2815 7968870 71.43 µM -0.959050765695541 0.207120907100813 no 2682 0.168766585741774 4034 2977326 YHR190W ERG9 SGTC_126 0417-1624 672.48 µM -0.963914015221794 0.205961793692142 no 2683 0.167544518310818 4099 41912 YDL195W SEC31 SGTC_224 benfluorex 43.875 µM -0.965368108780239 0.205615971690744 no 2684 0.167180234496673 4064 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1424 4048-1941 275 µM -0.966187949941975 0.20542114377268 no 2685 0.166975070738582 4113 X1424 SGTC_3236 9132701 49.47 µM -0.968687166064934 0.204827904305377 no 2686 0.166350648910403 4045 24282524 SGTC_2679 rapamycin 1 nM -0.971229613195957 0.204225449730633 no 2687 0.165716975215166 4001 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1139 k015-0024 46.9 µM -0.97414304182284 0.203536386934 no 2688 0.16499276044608 4086 2766652 SGTC_1426 4048-4480 71.7 µM -0.974180525091666 0.203527530710493 no 2689 0.164983456296004 4050 14224343 SGTC_2092 5303694 80.6725 µM -0.974583979090716 0.203432220630926 no 2690 0.164883331881648 4052 1963699 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.974645740457151 0.203417632765949 no 2691 0.164868008154292 4094 368090 SGTC_1845 st056753 3.01 µM -0.975912239049891 0.203118626918643 no 2692 0.16455397823432 4023 5375839 SGTC_985 1493-0307 8.71 µM -0.977265410924659 0.202799448617383 no 2693 0.164218886191367 4075 3278274 SGTC_754 3474-0146 171 µM -0.977516110710254 0.202740347929517 no 2694 0.164156852895751 4026 24762078 SGTC_4 0960-0234 25.671 µM -0.978553973182868 0.202495788761266 no 2695 0.163900205342516 4067 6821112 SGTC_2346 9031566 143.75 µM -0.978668717842705 0.202468761464833 no 2696 0.163871846732326 4030 4771086 SGTC_3284 9108171 64.8615 µM -0.978817374725729 0.202433749590434 no 2697 0.163835111608739 4047 8687505 SGTC_332 4112-0506 40.9 µM -0.979862542857217 0.202187692366719 no 2698 0.163576987340107 4013 2790355 SGTC_2954 9074818 52.69 µM -0.983866874341968 0.201246635638947 no 2699 0.162590486462387 4098 16648742 SGTC_1510 1123-0200 71.5 µM -0.985346832659231 0.200899496793575 no 2700 0.162226867927014 4140 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2753 fluvastatin 17.09 µM -0.985478710334025 0.200868581026159 no 2701 0.162194491937345 4101 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_432 NS 1619 61.3 µM -0.986328359598088 0.200669468239392 no 2702 0.161986003786397 4103 4552 A K+/calcium channel activator. SGTC_2022 5136654 200 µM -0.986350126096946 0.200664368882012 no 2703 0.161980664986155 4133 1713771 SGTC_1413 3910-0535 34.4 µM -0.986573252198427 0.200612100389468 no 2704 0.161925944113338 4077 2876951 SGTC_2841 9004761 38.96 µM -0.992356269115218 0.199260250857384 no 2705 0.160511881728747 4076 2991039 SGTC_978 1416-0512 87.4 µM -0.992565918933073 0.199211345971048 no 2706 0.160460770175633 4166 6814003 SGTC_2444 5485484 36.41 µM -0.994497590129255 0.198761086457635 no 2707 0.159990339031039 4165 6790631 SGTC_3011 9081274 71.4286 µM -0.99507306601478 0.198627065631277 no 2708 0.159850364586396 4082 6625322 SGTC_62 0180-0423 3.232 µM -0.995191795294062 0.198599421914589 no 2709 0.159821495737326 4032 30102 YGL099W LSG1 SGTC_2158 5657123 3.6195 µM -0.99608974700969 0.198390427126093 no 2710 0.159603270551538 4015 2858827 SGTC_1449 4112-4002 201 µM -0.996327068876739 0.198335213559736 no 2711 0.159545627876507 4143 2059539 SGTC_1295 1013-0063 9.78 µM -0.998612039749229 0.197804083596689 no 2712 0.158991332749139 4105 6826038 SGTC_775 4577-0580 57.3 µM -0.999447059891997 0.197610201982542 no 2713 0.158789086240403 4151 2006902 SGTC_2617 dihydrotanshinone i 20.83 µM -1.00150594331257 0.197132645107013 no 2714 0.158291134115426 4075 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_1572 epiandrosterone 68.9 µM -1.0052581075568 0.19626413071503 no 2715 0.157386290787345 4008 441302 A steroid. SGTC_3105 9121040 49.47 µM -1.00572004614232 0.196157366293489 no 2716 0.157275128711896 3965 41448907 SGTC_2490 carminic acid 95.39 µM -1.00633089190435 0.196016240158281 no 2717 0.157128212514743 4066 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_682 0kpi-0099 17 µM -1.00719204828933 0.195817388413613 no 2718 0.156921246777684 4137 1714895 YML126C ERG13 SGTC_2551 apiole 73.87 µM -1.00737668331121 0.195774769828845 no 2719 0.156876895940215 3969 10659 A possible DNA adduct former. SGTC_1055 3448-0672 86 µM -1.01024349447877 0.195113757507434 no 2720 0.156189322824016 4128 748378 SGTC_20 0481-0013 4.944 µM -1.01066360280063 0.195017005512064 no 2721 0.156088731514524 4129 182045 SGTC_1400 3771-8998 51.5 µM -1.01208034339125 0.194690941715192 no 2722 0.15574982002236 4001 670767 SGTC_160 3453-0671 289.699 µM -1.01333417258028 0.194402648926203 no 2723 0.155450285112179 4152 5322268 SGTC_3277 9138724 49.47 µM -1.0135221653363 0.194359446190458 no 2724 0.155405407162741 4050 15943418 SGTC_2070 5230947 200 µM -1.01356071935758 0.194350586788506 no 2725 0.155396204537946 4177 2835538 SGTC_2629 bisabolol 100 µM -1.01443391481197 0.194149999394733 no 2726 0.155187874069997 4141 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_792 4534-1957 155 µM -1.01578166733347 0.193840646052993 no 2727 0.154866683944013 4037 1717904 SGTC_1187 1391-0724 117 µM -1.01628599625752 0.193724963340564 no 2728 0.15474660759578 4149 6997986 SGTC_2740 felodipine 17.08 µM -1.01802363305063 0.193326707555931 no 2729 0.15433336252163 4120 3333 L-type calcium channel blocker SGTC_513 4245-1575 41.7 µM -1.01938199932368 0.193015726471287 no 2730 0.15401082426879 4012 719745 SGTC_7 0192-1582 4.227 µM -1.01938243070277 0.193015627760948 no 2731 0.154010721910565 4156 252616 SGTC_3075 9116269 49.47 µM -1.02017641630485 0.192833996216077 no 2732 0.153822400193886 4145 17015205 YNL244C SUI1 SGTC_822 1487-0950 154 µM -1.02070666219794 0.19271275573533 no 2733 0.153696718578385 4135 1958375 SGTC_1215 3852-0577 11.2 µM -1.02091639686171 0.192664812858859 no 2734 0.15364702495596 4159 2884876 SGTC_3076 9116187 49.47 µM -1.02165926464831 0.192495060660009 no 2735 0.153471098659945 4101 27241210 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.02532780838197 0.191658105748763 no 2736 0.152604269384467 4161 91467 include heat shock SGTC_2322 7413319 38.22 µM -1.02633380681638 0.191428983569763 no 2737 0.152367133615844 4155 1840400 SGTC_2071 5230951 39.92 µM -1.02670583372709 0.191344294738014 no 2738 0.15227950074297 4153 1799272 SGTC_1341 1486-1360 280 µM -1.02712713779959 0.191248416101223 no 2739 0.152180300787215 4100 3976547 SGTC_2056 5235370 200 µM -1.02733530928755 0.191201052168698 no 2740 0.152131300719749 4059 5511916 SGTC_1783 st039459 87.517 µM -1.02862185965276 0.190908491147001 no 2741 0.151828700881864 4224 729761 SGTC_2999 9069765 71.4286 µM -1.02983725629168 0.190632362856577 no 2742 0.151543204178189 4092 2097066 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -1.02993920987337 0.19060921097738 no 2743 0.151519271514469 4122 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1876 myriocin 605 nM -1.02999416192504 0.190596733041316 no 2744 0.151506373069011 4125 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_2025 5147754 141 µM -1.0320711689439 0.190125475771038 no 2745 0.15101938944185 4100 315777 YLR208W SEC13 SGTC_683 panaxydol 45 µM -1.03300393354174 0.189914071685727 no 2746 0.150801028927129 4113 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_2915 7971052 15.16 µM -1.03365375695615 0.189766879535964 no 2747 0.150649029329659 4043 5741558 SGTC_1053 3366-3204 134 µM -1.03402173441243 0.189683559716649 no 2748 0.150563001323075 4164 3632071 YPR165W RHO1 SGTC_1927 st060202 13.8 µM -1.03455367423737 0.189563154266753 no 2749 0.150438699046702 3995 688887 SGTC_139 0099-0334 718.624 µM -1.03638287600728 0.189149470450127 no 2750 0.150011777970953 4162 97690 SGTC_2436 5633522 8.09 µM -1.03856717643152 0.188656208089822 no 2751 0.14950303895246 4128 5724242 SGTC_445 e6 berbamine 66 µM -1.03882697340283 0.188597593116806 no 2752 0.149442607113165 4155 6610268 A calcium/calmodulin antagonist. SGTC_959 1222-0044 107 µM -1.03953664607043 0.188437535151464 no 2753 0.149277611995458 4142 6083612 SGTC_853 0419-0306 21 µM -1.04230746062389 0.187813414393884 no 2754 0.148634577254981 4160 762713 SGTC_1958 st076513 41.9 µM -1.04388753063707 0.187458078855319 no 2755 0.148268713971783 4092 732122 YGL099W LSG1 SGTC_692 k241-0027 77.8 µM -1.0439582675884 0.18744218083232 no 2756 0.148252349018665 4198 3600480 SGTC_419 nsc-638432 893 µM -1.04427640623733 0.187370689954025 no 2757 0.148178762763985 4096 368090 SGTC_1509 1326-1131 80 µM -1.04502480309314 0.187202579602626 no 2758 0.148005753106045 4110 768313 SGTC_3180 9109287 49.47 µM -1.0461835390189 0.186942479972033 no 2759 0.147738150678032 4184 18891271 SGTC_2308 7584454 197.62 µM -1.04732971809296 0.186685419055051 no 2760 0.147473767125978 4206 893577 SGTC_2667 digitoxin 100 µM -1.04773477381376 0.186594626973122 no 2761 0.147380410746764 4066 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1942 st076330 65.2 µM -1.04892619551128 0.186327731727138 no 2762 0.14710604401545 4209 24208414 SGTC_3246 9135460 32.98 µM -1.05066903445819 0.185937737542836 no 2763 0.146705311322137 4111 41446951 SGTC_1035 k081-0041 55.2 µM -1.05081004821193 0.185906205115566 no 2764 0.14667291994969 4168 731709 SGTC_951 1171-0579 82.7 µM -1.05096869206878 0.185870734342295 no 2765 0.146636484615304 4100 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -1.05102805268601 0.185857463133177 no 2766 0.146622852973764 4197 23847180 SGTC_3030 9087619 49.47 µM -1.05257470599929 0.185511886155238 no 2767 0.146267977436247 4176 25236973 SGTC_753 1322-0200 289 µM -1.05291088652649 0.185436824346265 no 2768 0.146190918073562 4219 5403907 SGTC_2768 sulfasalazine 50.2 µM -1.05519392103253 0.184927571220932 no 2769 0.145668321907541 4099 5384001 An antioxidant and salicylic acid derivative. SGTC_938 3126-1755 342 µM -1.05535069364561 0.184892633476406 no 2770 0.145632482140907 4152 1777771 SGTC_1310 1188-0297 994 nM -1.05583560351728 0.184784594287046 no 2771 0.145521664490391 4020 1588352 SGTC_977 1348-1378 135 µM -1.05600936295791 0.184745889780879 no 2772 0.145481968620902 4131 X977 SGTC_1643 st009866 20.2 µM -1.05650192511654 0.184636200114776 no 2773 0.145369480892115 4088 3156273 YOR207C RET1 SGTC_2748 diazoxide 86.69 µM -1.05770001753263 0.184369563573526 no 2774 0.14509611363379 4202 3019 A potassium channel activatior. SGTC_2828 7998861 71.43 µM -1.05968905825249 0.183927430086666 no 2775 0.144643041125281 4133 2988188 SGTC_3139 9095020 49.47 µM -1.06628418555237 0.182466163342866 no 2776 0.143147598084062 3872 25236292 SGTC_1654 st012436 41.8 µM -1.06758627779945 0.182178521398788 no 2777 0.142853588092159 4141 4323132 SGTC_3251 9135047 49.47 µM -1.06797604976369 0.18209247299664 no 2778 0.142765657742334 4187 17682963 SGTC_1144 3486-0183 12.5 µM -1.06845590255963 0.181986572710295 no 2779 0.142657455924816 4150 6744069 SGTC_501 nsc-95397 161 µM -1.0695569307997 0.181743728775842 no 2780 0.142409395119106 4203 262093 SGTC_2474 5321570 43.32 µM -1.07102686357527 0.181419835040973 no 2781 0.142078675463322 4166 2841384 SGTC_1306 1185-0270 9.02 µM -1.07151574434671 0.181312192271913 no 2782 0.14196879764527 4197 1548076 SGTC_2831 7999036 19.48 µM -1.07224120354329 0.181152532905054 no 2783 0.141805853973754 4207 2988270 SGTC_2292 7671323 168.05 µM -1.07484228443294 0.180580810173669 no 2784 0.14122267277847 4240 937504 SGTC_1668 st014914 51.6 µM -1.07648217279774 0.180220941743716 no 2785 0.140855834784373 4173 2839556 SGTC_1003 4049-0218 100 µM -1.07833239883321 0.179815456179729 no 2786 0.140442721706449 4207 295161 SGTC_3205 9113483 49.47 µM -1.08121662672087 0.179184508332473 no 2787 0.139800381847921 4218 17018033 SGTC_1097 itavastatin 7.23 µM -1.08236341380942 0.178934026898036 no 2788 0.139545539240849 4191 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -1.08384369038568 0.178611030597798 no 2789 0.139217054937011 4187 16486 A toxic proline analog. SGTC_3176 9106582 49.47 µM -1.08529781702181 0.178294097949849 no 2790 0.138894886220793 4131 17018027 SGTC_576 1073-0113 22.7 µM -1.08602469844921 0.178135804203196 no 2791 0.13873403261779 4311 5439563 SGTC_2123 5259487 200 µM -1.08932706579218 0.177417760146634 no 2792 0.138004840666795 4198 2173474 SGTC_65 0798-0905 34.986 µM -1.09050022472123 0.177163117007642 no 2793 0.137746427188954 4286 3602145 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.09118765158609 0.177014013060007 no 2794 0.137595160161719 4069 6708630 An antioxidant. SGTC_2376 9072922 81.32 µM -1.09994294907493 0.17512191581179 no 2795 0.135678490004598 4205 17087968 SGTC_179 1273-0063 6.77 µM -1.10280228944322 0.17450677635161 no 2796 0.135056516837005 4152 3108139 SGTC_956 1185-0240 191 µM -1.10436570133516 0.174171015361323 no 2797 0.134717266431585 4176 1416193 SGTC_369 0957-0393 4.5 µM -1.10470065763275 0.174099133020826 no 2798 0.134644659182691 4230 6997992 SGTC_2774 tamoxifen 10.92 µM -1.10490659041583 0.174054948765809 no 2799 0.134600033222212 4183 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2746 daunorubicin 9.88 µM -1.10654934817116 0.173702739391541 no 2800 0.134244408512892 4147 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_485 niflumic acid 177 µM -1.1078511562473 0.173423952320815 no 2801 0.133963051410808 4252 4488 A COX2 inhibitor. SGTC_3250 9135583 49.47 µM -1.10921409091911 0.173132380129846 no 2802 0.133668917631183 4248 7699353 SGTC_1282 0886-0010 32.4 µM -1.110534929052 0.172850111728944 no 2803 0.133384292628752 4247 2836211 YNL267W PIK1 SGTC_2616 abietic acid 100 µM -1.11212401508475 0.172510906581853 no 2804 0.133042416251547 4250 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_3095 9117207 49.47 µM -1.11288279929895 0.172349086906656 no 2805 0.132879384171557 4181 17015229 SGTC_1311 1190-0148 100 µM -1.11406520603294 0.172097117822647 no 2806 0.132625607014166 4251 1961333 SGTC_2027 5150920 200 µM -1.11816117933832 0.171226091201337 no 2807 0.131749080495952 4156 786715 SGTC_266 formosanin C 406 nM -1.11837477333453 0.171180746966927 no 2808 0.131703481904225 4087 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_1379 2144-0755 36.5 µM -1.11922932832266 0.170999408853758 no 2809 0.131521158271141 4266 5392327 SGTC_3249 9135183 49.47 µM -1.126581616678 0.169444319617535 no 2810 0.129959707594604 4206 4902779 SGTC_2827 7993847 71.43 µM -1.12661039564311 0.169438250438762 no 2811 0.129953620950205 4293 2985692 SGTC_1309 pyrazolanthrone 13.4 µM -1.12814005527937 0.16911586220786 no 2812 0.12963038757913 4199 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2148 5546263 113.568 µM -1.12826763355128 0.169088991855368 no 2813 0.129603454113651 4206 792097 SGTC_1925 st057770 10.1 µM -1.12899717575174 0.168935389394468 no 2814 0.129449512540514 4213 5989122 SGTC_27 0485-0001 32.618 µM -1.12924470852783 0.168883292639887 no 2815 0.129397309151396 4172 2054479 SGTC_1803 st050068 52.4 µM -1.13267467920926 0.168162469667294 no 2816 0.128675447370436 4280 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1330 1469-0054 61.8 µM -1.1328620894729 0.16812314171628 no 2817 0.128636086212226 4222 7102664 SGTC_514 4466-0038 2.65 nM -1.1334466311611 0.168000513952506 no 2818 0.128513370527932 4042 5722064 SGTC_3181 9108277 49.47 µM -1.13374072983599 0.16793883839325 no 2819 0.128451659694893 4184 17097298 SGTC_2847 9005661 71.43 µM -1.13667300412786 0.167324707100305 no 2820 0.127837504372301 4244 2991449 SGTC_1880 MG-132 525 µM -1.13725170316129 0.167203676435052 no 2821 0.127716539243492 4184 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_816 0325-0417 81.3 µM -1.13751260523052 0.167149129139354 no 2822 0.127662029061566 4245 68101 SGTC_1885 st057546 99.9 µM -1.13802852983629 0.167041297571655 no 2823 0.127554284723588 4254 702008 SGTC_1562 morin hydrate 59.1 µM -1.13831874080425 0.166980661326889 no 2824 0.12749370562111 4272 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_730 1436-0052 41.2 µM -1.14016103707639 0.166596065844173 no 2825 0.127109608364416 4264 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_695 3505-6186 243 µM -1.1425290626534 0.166102560189611 no 2826 0.126617086392257 4228 1819379 SGTC_354 2783-3500 4.88 µM -1.14355658469276 0.16588871476712 no 2827 0.126403787714273 4249 6740761 SGTC_3242 9133940 49.47 µM -1.14681066406077 0.165212658256619 no 2828 0.125729940422059 4250 17248444 SGTC_1760 st045453 10.4495 µM -1.14713711549893 0.165144934367541 no 2829 0.125662478176296 4281 3323419 YIL048W NEO1 SGTC_896 0964-0007 44.5 µM -1.15365637346128 0.16379624714688 no 2830 0.124320538261508 4207 6756758 SGTC_572 0960-0087 17.7 µM -1.15371345409979 0.163784470110954 no 2831 0.124308833075344 4223 6796365 SGTC_1120 ficusin 1.78878 µM -1.15440595135381 0.163641635935653 no 2832 0.124166888190488 4279 6199 A DNA cross-linker. SGTC_1264 0783-0040 158 µM -1.15680467658048 0.163147501382433 no 2833 0.123676085376621 4147 2855798 SGTC_1612 st002233 45.4 µM -1.15789419430564 0.162923382604078 no 2834 0.123453608527109 4248 1035021 SGTC_1969 st069479 40.1 µM -1.16214331863621 0.162051231940856 no 2835 0.122588626983392 4249 3895485 SGTC_2439 5492030 7.2 µM -1.16300513676336 0.161874711736854 no 2836 0.122413709153665 4242 5722370 SGTC_1828 st055811 49 µM -1.1634743379865 0.161778661207225 no 2837 0.122318551992727 4255 5877589 SGTC_2416 tofa 880 nM -1.16776839534514 0.160901347237352 no 2838 0.121450099839096 4249 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2891 9063876 19.48 µM -1.16852730663881 0.160746618486285 no 2839 0.121297065601334 4272 6472478 SGTC_1096 rimcazole 32.2 µM -1.16923994874151 0.160601411699082 no 2840 0.121153485031248 4184 18528119 A dopamine reuptake inhibitor. SGTC_1750 st081859 2.357 µM -1.169245193885 0.160600343274953 no 2841 0.121152428701951 4211 5291695 SGTC_2161 5662504 8.5105 µM -1.16934070501083 0.160580888681819 no 2842 0.121133194669997 4222 2859334 SGTC_2375 9072683 200 µM -1.16959606912783 0.160528881307134 no 2843 0.121081779989212 4341 16798029 SGTC_1605 st000082 49.1 µM -1.16985972838215 0.160475196094059 no 2844 0.121028711286301 4212 1114022 SGTC_2524 avocatin b 10.57 µM -1.17138139561143 0.160165589698024 no 2845 0.120722753503864 4242 6710748 SGTC_1203 3992-3522 103 µM -1.17184320806777 0.160071704203852 no 2846 0.12063000582762 4375 5322312 SGTC_2989 9073649 71.4286 µM -1.17254468910804 0.159929163450285 no 2847 0.120489220529758 4227 21367202 SGTC_1350 1495-0454 146 µM -1.17279240740952 0.159878847000449 no 2848 0.120439531810774 4306 1069057 SGTC_167 3672-0051 66.205 µM -1.17306627227096 0.159823231724157 no 2849 0.12038461526803 4176 3237971 SGTC_1107 amlodipine 47 µM -1.17369296261516 0.159696013816235 no 2850 0.120259015028719 3927 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_185 k048-0037 25.491 µM -1.17524666010403 0.15938089965519 no 2851 0.119948023808203 4319 6827589 SGTC_1720 st037298 9.481 µM -1.17844304388187 0.158733904186547 no 2852 0.119310013073856 4268 597396 SGTC_90 0870-0863 4.608 µM -1.17932565397252 0.158555554607428 no 2853 0.119134263368357 4292 1738164 SGTC_635 k038-0028 24.7 µM -1.17992542776688 0.158434432961423 no 2854 0.119014937774573 4266 4035102 SGTC_1024 4507-0395 26 µM -1.1813362209597 0.15814976891029 no 2855 0.118734591845655 4311 4201836 SGTC_2550 chrysin dimethyl ether 71.87 µM -1.18152137430553 0.158112434363732 no 2856 0.118697833737052 4109 88881 An O-methylated flavonoid and antioxidant. SGTC_574 1315-0397 40 µM -1.18330052658903 0.157753978823596 no 2857 0.118345032095851 4248 6794277 SGTC_249 wiskostatin 11.211 µM -1.19047352921376 0.156314213107368 no 2858 0.116930164043484 4266 2775510 A n-wasp and actin depolymerizer. SGTC_3117 9124945 49.47 µM -1.19048835145441 0.156311246975433 no 2859 0.116927252836308 4175 17592065 SGTC_3085 9117376 49.47 µM -1.19067579349293 0.156273740473217 no 2860 0.116890442145965 4366 16480349 SGTC_97 0535-0701 19.132 µM -1.19998705423218 0.154418051484249 no 2861 0.115072184128817 4187 2832013 YGL099W LSG1 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.20269707911354 0.153880705010868 no 2862 0.114546782321574 4415 16725076 SGTC_2725 haloperidol 53.21 µM -1.20391079388464 0.153640450120707 no 2863 0.114312029695001 4222 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_257 daunorubicin 18.5 µM -1.20666283407995 0.153096604171405 no 2864 0.113781008857493 4306 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3261 9137475 49.47 µM -1.20747648588965 0.152936058605166 no 2865 0.113624347671931 4242 17027690 SGTC_1317 1273-0028 910 nM -1.20923252778265 0.152589946055848 no 2866 0.113286762159026 4311 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1162 k048-0130 20.1 µM -1.21147825845816 0.152148074615458 no 2867 0.112856081153006 4253 6797406 SGTC_1477 0139-0234 16 µM -1.21147833428748 0.152148059709592 no 2868 0.112856066630398 4298 620880 SGTC_1540 guanosine 70.6 µM -1.21171710748384 0.152101128564931 no 2869 0.112810344104641 4212 6802 Guanosine is a purine nucleoside SGTC_624 k048-0052 28 µM -1.21237222579601 0.151972413689317 no 2870 0.112684963846237 4279 6835531 SGTC_3287 9117173 37.0625 µM -1.21279240545151 0.151889896663441 no 2871 0.112604599879149 4297 2789709 SGTC_3100 9120536 49.47 µM -1.21297729147158 0.151853597235137 no 2872 0.112569251371779 4170 16421196 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.21676501010413 0.151111207562206 no 2873 0.111846818165471 4246 279621 SGTC_1406 3909-7906 11.9 µM -1.21827098106752 0.15081671058318 no 2874 0.11156050688702 4321 X1406 SGTC_1174 0739-0097 51.1 µM -1.2201118330255 0.150457245975713 no 2875 0.111211241709014 4338 728447 SGTC_3026 9090633 49.47 µM -1.22190201160131 0.150108224256817 no 2876 0.110872342333118 4304 25236842 SGTC_49 0717-0965 32.132 µM -1.22573784260393 0.149362191026901 no 2877 0.110148672291877 4376 5889349 YGL099W LSG1 SGTC_2861 9024595 19.48 µM -1.22661027377679 0.149192857437445 no 2878 0.109984552953166 4213 16482810 SGTC_1771 st048882 4.1505 µM -1.22865815255222 0.148795880448641 no 2879 0.109600001165789 4349 4580403 SGTC_3033 9090887 49.47 µM -1.22975196549849 0.148584136596605 no 2880 0.10939500035369 4321 19325384 SGTC_2742 clothiapine 36.27 µM -1.23030260938511 0.148477617443814 no 2881 0.109291903775031 4339 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_121 0557-0495 61.343 µM -1.23135680126109 0.148273832087747 no 2882 0.109094723114517 4387 3104427 SGTC_1243 0416-0003 5.65 µM -1.2335295012963 0.147854418896846 no 2883 0.108689138533123 4306 2141977 SGTC_3326 9140064 16.379 µM -1.23403554549876 0.147756847402835 no 2884 0.108594829607459 4251 1868434 SGTC_3153 9100258 49.47 µM -1.23645856205935 0.147290257851803 no 2885 0.108144079766595 4243 25236848 SGTC_207 4185-0010 4.486 µM -1.24385851032132 0.145871401545367 no 2886 0.106775820798552 4397 3761753 SGTC_3202 9113761 49.47 µM -1.24442602401951 0.145762967735541 no 2887 0.106671404960386 4269 4798415 SGTC_2563 tomatine 8.54 µM -1.24560097290227 0.1455386446347 no 2888 0.106455462472088 4296 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2985 9022375 71.43 µM -1.24571198154674 0.145517462697985 no 2889 0.106435076653051 4372 4939335 SGTC_1571 st070080 73.4 µM -1.25217357607453 0.14428807589444 no 2890 0.105253311129525 4338 4315245 SGTC_1930 st074634 34.3 µM -1.25279534453087 0.14417014820265 no 2891 0.105140098176974 4222 684253 YOR116C RPO31 SGTC_547 1120-0019 610 nM -1.2558596695097 0.143589902610621 no 2892 0.104583426547177 4284 3676939 SGTC_2575 plumbagin 510 nM -1.25780465663743 0.14322242820625 no 2893 0.104231205605825 4239 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1217 1183-1422 255 µM -1.25810080992062 0.143166530521985 no 2894 0.104177650234418 4360 2849664 SGTC_1324 1418-0026 34.4 µM -1.26267178613831 0.142305646994125 no 2895 0.103353578778488 4381 1372513 SGTC_3281 9140613 49.47 µM -1.26296285245897 0.142250947326977 no 2896 0.103301265050336 4343 16013766 SGTC_742 0kpi-0133 140 µM -1.26335853870337 0.142176609410285 no 2897 0.10323017868263 4357 2728852 SGTC_1893 st059353 36.1 µM -1.26446443314568 0.141968983505311 no 2898 0.103031689399045 4362 3112488 SGTC_191 3914-0123 66.505 µM -1.26624093151883 0.141635885134728 no 2899 0.102713418679417 4357 3144412 SGTC_2645 abamectin 100 µM -1.26733345932126 0.141431296271811 no 2900 0.102518040712824 4291 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1982 st072467 71.9 µM -1.2695608859443 0.141014804722191 no 2901 0.102120544782759 4319 3163533 SGTC_1127 asiatic acid 681.4 nM -1.27225069029176 0.140512966080883 no 2902 0.101642031185085 4293 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1979 st071809 45.3 µM -1.27441739097889 0.140109605931485 no 2903 0.101257766089431 4386 4976333 SGTC_2007 4011539 71.82 µM -1.27739742868255 0.139556118429965 no 2904 0.100730986053875 4300 45595301 SGTC_442 cape 100 µM -1.27757399955089 0.139523370348544 no 2905 0.100699836531599 4355 5281787 SGTC_833 3852-0053 558 µM -1.2786002650052 0.139333135375128 no 2906 0.100518928307155 4399 3123681 SGTC_2641 levomentholum 100 µM -1.28178314122739 0.138744260320851 no 2907 0.0999593648843833 4353 16666 SGTC_309 k408-0051 1.48 µM -1.28271745865275 0.138571721293967 no 2908 0.0997955405354573 4260 3640463 SGTC_2963 9082507 9 µM -1.28328647298139 0.138466713910167 no 2909 0.099695865019533 4373 16459611 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -1.28354714659623 0.138418626639149 no 2910 0.099650226539468 4324 364106 SGTC_2560 caryophyllene 100 µM -1.28456837723636 0.138230346696451 no 2911 0.0994715775342762 4388 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.28474863646467 0.138197131208589 no 2912 0.099440068204032 4352 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_669 0108-0021 26.2 µM -1.28693130687811 0.137795373050695 no 2913 0.099059116065516 4376 17201 SGTC_1830 st055982 50.3 µM -1.28752208178506 0.137686767912163 no 2914 0.0989561890374459 4331 455313 An antimicrobial agent. SGTC_2928 9011484 9.79 µM -1.29814595677902 0.135743695689504 no 2915 0.0971185923864954 4367 2994751 SGTC_1560 lithocholic acid 53.1 µM -1.29984311881479 0.135435038680037 no 2916 0.0968273718350028 4298 9903 A bile acid which acts as a detergent. SGTC_578 3460-0051 92 µM -1.30130463017277 0.135169624362542 no 2917 0.0965771014977075 4421 2876744 SGTC_2927 9011802 47.9 µM -1.30410995415035 0.134661169919135 no 2918 0.0960980477198775 4357 43912568 SGTC_1296 1068-0102 11.9 µM -1.30421590043548 0.134641993308884 no 2919 0.0960799900012465 4354 767053 SGTC_2251 lansoprazole 556 µM -1.30426275344444 0.134633513364887 no 2920 0.0960720050666737 4324 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_2255 7941087 197.44 µM -1.30575456787895 0.134363700930833 no 2921 0.0958180172933956 4467 935561 SGTC_2067 5224629 34.075 µM -1.30750166808664 0.134048189346612 no 2922 0.0955211943811941 4364 2835000 SGTC_1626 st003712 1.76 µM -1.31048765797903 0.133510123966522 no 2923 0.0950154583725891 4402 24207035 SGTC_1495 4469-0029 237 µM -1.31082267521183 0.133449847790362 no 2924 0.0949588399194653 4378 793680 SGTC_1974 st069448 26.9 µM -1.31089558629553 0.13343673213574 no 2925 0.0949465211225075 4364 6323587 YNR016C ACC1 SGTC_1262 0737-0114 49.6 µM -1.31177520425864 0.133278571395092 no 2926 0.0947979967735386 4409 765919 SGTC_1293 1000-1278 195 µM -1.31315568407553 0.133030612751678 no 2927 0.0945652467158012 4396 678847 SGTC_344 k064-0035 6.43 µM -1.31342715187892 0.132981889709324 no 2928 0.0945195266243468 4320 5088750 SGTC_674 0498-0004 451 µM -1.31394763951279 0.132888506947304 no 2929 0.094431912666818 4341 4231473 SGTC_2570 licareol 100 µM -1.3140592698149 0.132868484791356 no 2930 0.0944131296807238 4347 443158 SGTC_1049 3226-0134 66 µM -1.31734841501659 0.132279471580525 no 2931 0.0938609317850109 4405 5702385 SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.31830156593714 0.132109120192767 no 2932 0.0937013584819975 4494 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_824 1304-0008 100 µM -1.32256720748883 0.131348599373048 no 2933 0.0929896727568084 4407 768245 SGTC_988 1497-1057 103 µM -1.32491423521519 0.130931439752902 no 2934 0.0925997994234558 4365 3533044 SGTC_3190 9110366 49.47 µM -1.3262658143469 0.130691626553548 no 2935 0.0923758330364578 4391 17123768 SGTC_2776 terbinafine 19.92 µM -1.32716407067633 0.130532415327705 no 2936 0.0922272073913684 4397 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1698 5-fluorocytosine 1.055 µM -1.32798936882458 0.130386253827611 no 2937 0.0920908095079411 4402 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1340 1486-1359 257 µM -1.32884289989041 0.13023521135926 no 2938 0.0919499027026143 4327 4309068 SGTC_2291 7917025 104.35 µM -1.3299429044501 0.130040731085594 no 2939 0.0917685419120522 4278 2964612 SGTC_3265 9137266 49.47 µM -1.332381537275 0.129610299024424 no 2940 0.0913674229396663 4350 17224265 SGTC_471 1-acyl-paf 4 µM -1.33282185656932 0.129532685560274 no 2941 0.091295135675257 4349 16759367 SGTC_3344 9148862 3.898 µM -1.33622482252007 0.128933943237557 no 2942 0.0907379000140941 4417 4905352 SGTC_1981 st071826 47 µM -1.33872230400674 0.128495741466488 no 2943 0.0903305462515528 4429 11838600 SGTC_2739 tacrine 100.86 µM -1.33962675586125 0.128337303895464 no 2944 0.0901833603598043 4436 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_3319 9138450 16.7555 µM -1.3401468083707 0.128246265013536 no 2945 0.0900988103689231 4321 2029690 SGTC_2331 7980721 200 µM -1.34163182432292 0.127986549334077 no 2946 0.0898577010938677 4351 2981221 SGTC_943 3253-1379 105 µM -1.34279995189059 0.127782511458498 no 2947 0.0896683794962827 4386 668464 SGTC_881 0833-0569 170 µM -1.34589117651341 0.127243655605182 no 2948 0.0891688074124484 4408 5418700 SGTC_1279 0874-0590 65.2 µM -1.34670243481973 0.127102500999172 no 2949 0.0890380438989282 4457 3523074 SGTC_2549 cedrol 20.94 µM -1.3486443466853 0.126765061415035 no 2950 0.0887256146389565 4342 6708665 A sedative which affects the nervous system. SGTC_922 1866-0035 480 µM -1.35590961076198 0.125508135286138 no 2951 0.0875639646238931 4332 3156169 SGTC_2330 7979373 200 µM -1.35656468237927 0.12539523367028 no 2952 0.0874597850114781 4336 1863007 SGTC_2931 9014674 55.67 µM -1.35861161993365 0.125042900846564 no 2953 0.087134845547866 4356 2996810 SGTC_2794 7785382 27.27 µM -1.36074550628139 0.124676338575062 no 2954 0.0867970641606233 4403 2205081 SGTC_3155 9099265 49.47 µM -1.36222942794779 0.124421871395737 no 2955 0.0865627457029284 4382 25236499 SGTC_294 k038-0071 157 µM -1.36672470820697 0.123653225040523 no 2956 0.0858558050983888 4417 24152826 SGTC_2395 5646831 180.19 µM -1.37350838836086 0.122499591381619 no 2957 0.0847971776372473 4404 6808628 SGTC_2084 5306078 60.6385 µM -1.37713232343544 0.121886408804843 no 2958 0.0842356703986905 4363 679340 SGTC_2374 9071832 200 µM -1.37986863955982 0.121424845346024 no 2959 0.0838135469627416 4358 17381698 SGTC_1082 camptothecin 424.86 nM -1.38208210728555 0.121052376384865 no 2960 0.0834732458564654 4298 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2780 5215298 71.43 µM -1.38300409410037 0.120897467398509 no 2961 0.0833318052750916 4444 2834131 SGTC_2697 mebhydrolin 72.4 µM -1.38400092192634 0.120730140892684 no 2962 0.0831790862229719 4455 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_320 4092-0846 5.34 µM -1.3895442491129 0.119802617547644 no 2963 0.0823336576198266 4388 1359356 SGTC_2557 derrustone 83.84 µM -1.39348836416212 0.119145744996829 no 2964 0.0817360806209846 4407 629853 An antioxidant. SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -1.39378062642147 0.119097171563442 no 2965 0.0816919301116008 4414 442882 SGTC_857 0438-0306 1.35 µM -1.39393577970026 0.119071391064299 no 2966 0.0816684992354484 4487 4686136 SGTC_552 k242-0005 476 µM -1.39976437001402 0.118105756727885 no 2967 0.0807919453338781 4480 4088318 SGTC_3090 9117696 49.47 µM -1.40266762840535 0.117626839983168 no 2968 0.0803579873858888 4396 7923821 SGTC_1731 st035964 63 µM -1.40336964517691 0.117511243119954 no 2969 0.0802533199408442 4357 6739575 SGTC_114 0364-0001 490.298 µM -1.40387963827883 0.117427316089106 no 2970 0.080177346971548 4460 4003655 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.40517750502941 0.117213924083049 no 2971 0.0799842507705908 4440 6728940 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.40530838277121 0.117192420748649 no 2972 0.0799647983557155 4479 165521 SGTC_2843 9000894 45.46 µM -1.40698084517163 0.116917879628998 no 2973 0.0797165343910736 4406 2242070 SGTC_1587 estradiol valerate 56.1 µM -1.41494771112532 0.11561634589643 no 2974 0.0785419138224974 4486 13791 A steroid. SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -1.41544233279268 0.11553588107524 no 2975 0.0784694225508231 4375 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_584 0986-0246 15.4 µM -1.41641908358963 0.115377100596435 no 2976 0.0783264198994158 4521 53315 YDR232W HEM1 SGTC_994 3910-0338 138 µM -1.41757655858318 0.115189142471498 no 2977 0.0781572140034907 4513 3479481 SGTC_642 0335-0876 158 µM -1.4189394905446 0.11496810014587 no 2978 0.0779583289285261 4481 6812350 SGTC_302 1094-0063 18.9 µM -1.42020061984577 0.114763837196669 no 2979 0.0777746416327144 4414 5440289 SGTC_288 1315-0019 35.1 µM -1.42140980680312 0.114568229856097 no 2980 0.0775988285714911 4491 6811474 SGTC_2862 9027634 71.43 µM -1.42220526143258 0.114439680487274 no 2981 0.0774833359119892 4411 5012562 SGTC_2152 5568786 200 µM -1.4282265150438 0.113469945973022 no 2982 0.0766133355582224 4470 5399883 SGTC_865 0488-0499 301 µM -1.4297666819947 0.113222843001449 no 2983 0.0763919973181186 4402 9634651 SGTC_637 1181-0519 7.26 µM -1.43636198279858 0.112169041225378 no 2984 0.0754496825560383 4471 6252091 YGR060W ERG25 SGTC_987 1497-1013 404 µM -1.44073645389975 0.111473963383064 no 2985 0.0748295760216117 4476 1676435 SGTC_286 k060-0067 22.9 µM -1.44847313902758 0.110252206503776 no 2986 0.0737423864560179 4491 5985051 SGTC_425 3825-7017 13.1 µM -1.45080687112255 0.109885562076636 no 2987 0.0734168229104087 4485 3397440 SGTC_884 0851-0618 334 µM -1.45403678561468 0.109379566374213 no 2988 0.0729680538972016 4484 9642473 SGTC_2685 mycophenolic acid 18.85 µM -1.45463772110699 0.109285609277992 no 2989 0.072884791198418 4465 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_3132 9126706 49.47 µM -1.45495582512819 0.109235896750635 no 2990 0.0728407457030248 4490 850858 SGTC_3149 9097855 49.47 µM -1.46101808411707 0.108291605136924 no 2991 0.0720052393175341 4459 25236625 YMR079W SEC14 SGTC_2764 methyldopa 94.69 µM -1.46259341738032 0.108047186855147 no 2992 0.0717893327659581 4438 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2172 5754775 163.918 µM -1.46517476216433 0.107647541577636 no 2993 0.0714366216878399 4468 2263357 SGTC_1031 k035-0009 16 µM -1.46629594016656 0.107474292315981 no 2994 0.071283840513224 4514 5180959 SGTC_2536 dehydroabietamide 32.04 µM -1.46833268663193 0.10716007975992 no 2995 0.0710069381505576 4520 3983547 SGTC_875 0709-0210 25.7 µM -1.46983191351163 0.106929214968376 no 2996 0.0708036417503344 4449 6251364 SGTC_1801 st050089 28.441 µM -1.47007351312882 0.106892044824982 no 2997 0.0707709225241602 4529 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2101 5377231 179.231 µM -1.4748980923042 0.106151733303658 no 2998 0.0701199716530056 4498 2844213 SGTC_1835 st008666 49.2 µM -1.47554945539002 0.106052068841505 no 2999 0.0700324412567887 4433 690455 SGTC_2130 NSC 7 2.4545 µM -1.47593731775672 0.105992754505405 no 3000 0.0699803601236995 4526 21448 SGTC_655 k060-0012 42 µM -1.47981856428777 0.105400529816725 no 3001 0.0694608365133828 4476 5994525 SGTC_1138 3761-0006 1.03 µM -1.48256529018001 0.104982866122017 no 3002 0.0690949724048946 4514 12061087 SGTC_1895 st058434 18.3 µM -1.48790890603807 0.104173757813366 no 3003 0.0683874593280333 4476 5393175 SGTC_3064 1327-0027 10 µM -1.4915691713628 0.103622150326267 no 3004 0.0679060625354664 4448 16000455 YPR107C YTH1 SGTC_122 0236-0016 402.397 µM -1.49168598109883 0.103604581887488 no 3005 0.0678907429596182 4486 6808838 SGTC_2341 7987486 176.74 µM -1.49316605303852 0.103382163017228 no 3006 0.0676968628756481 4505 1258686 SGTC_1132 3456-3614 2.5 µM -1.49674554570774 0.102845685470335 no 3007 0.0672297401299602 4472 3125502 SGTC_1872 amphotericin b 148 nM -1.49711770254873 0.10279002465379 no 3008 0.0671813171394594 4504 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_3086 9117350 49.47 µM -1.50198317885222 0.102064343402605 no 3009 0.0665507265459567 4468 2679265 SGTC_971 1315-0384 26.7 µM -1.50908960561589 0.101011135729762 no 3010 0.0656379427471542 4519 6769120 SGTC_2289 7946404 165.07 µM -1.50956093655238 0.100941563335614 no 3011 0.0655777476705974 4473 1246120 YPR165W RHO1 SGTC_2926 9010726 65.15 µM -1.51104927971769 0.100722100756871 no 3012 0.0653879479079082 4487 2994293 SGTC_1642 st009582 77.7 µM -1.51166000380173 0.100632147637949 no 3013 0.065310189216112 4496 6739311 SGTC_2600 tangeritin 87.95 µM -1.51369121472379 0.100333393583877 no 3014 0.0650520870894584 4413 68077 A bioactive flavone. SGTC_575 k072-0246 11.9 µM -1.51540193880562 0.100082279874237 no 3015 0.0648353233596774 4589 6796779 SGTC_925 2064-1272 59.6 µM -1.51589853994688 0.100009470812051 no 3016 0.0647725047835919 4483 6815817 SGTC_1817 st052116 64.4 µM -1.51753080289233 0.0997704294630448 no 3017 0.064566361278073 4529 4361398 SGTC_2539 epi(13)torulosol 80 µM -1.51777958207434 0.0997340329810409 no 3018 0.0645349869960863 4469 6708597 SGTC_2779 methotrexate 400 µM -1.51794999092336 0.0997091077048837 no 3019 0.0645135030651536 4493 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_893 0958-0369 48.9 µM -1.52013137679352 0.099390443773975 no 3020 0.0642389800502382 4377 6819948 SGTC_2189 6047310 154.431 µM -1.52139605941879 0.0992060360988843 no 3021 0.0640802385821995 4500 711535 SGTC_1773 st048542 73.5835 µM -1.52163293864007 0.0991715237718218 no 3022 0.0640505397216166 4490 3237138 SGTC_1407 3909-7909 12.3 µM -1.52542058970375 0.098620870744106 no 3023 0.0635771132139355 4529 4411780 SGTC_403 arphamenine a 50 µM -1.5288093815115 0.0981301042481835 no 3024 0.0631558529897185 4513 5487158 An arginine aminopeptidase inhibitor. SGTC_2382 9035899 200 µM -1.52892669146931 0.0981131474610128 no 3025 0.0631413092247841 4509 6462679 SGTC_3114 9122766 49.47 µM -1.52899209108524 0.0981036950833105 no 3026 0.0631332022932333 4500 17176985 SGTC_627 1391-0720 175 µM -1.53193422548405 0.0976791505866646 no 3027 0.0627693333362888 4485 997839 SGTC_1244 0416-0015 52.5 µM -1.53325634179772 0.0974888109581367 no 3028 0.0626063535124577 4488 96201 SGTC_2930 9013230 14.89 µM -1.53565137130964 0.0971447014452553 no 3029 0.0623119538313472 4490 2995857 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -1.53714611519609 0.0969303940845262 no 3030 0.0621287661511678 4511 688662 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -1.54139334786718 0.0963233461348018 no 3031 0.0616105410239097 4516 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2338 7999974 200 µM -1.54276713743449 0.0961275926001766 no 3032 0.0614436428072576 4499 315925 SGTC_246 cycloheximide 667 µM -1.54886422805755 0.0952623370118505 no 3033 0.0607071808759272 4447 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_902 1120-0002 2.07 µM -1.54936673995374 0.0951912807268025 no 3034 0.0606467922120128 4505 3280475 SGTC_2653 dihydrofissinolide 100 µM -1.55071231790958 0.0950012052405109 no 3035 0.0604853206228537 4581 6857746 SGTC_106 0092-0003 11.579 µM -1.55115041900377 0.0949393797310091 no 3036 0.0604328204156888 4444 1072148 SGTC_2784 7567673 72.73 µM -1.55229729869354 0.0947776706578116 no 3037 0.0602955519931809 4446 3471247 SGTC_346 4513-0042 7.16 µM -1.55538887289632 0.0943427724747541 no 3038 0.0599267412750827 4466 2827372 SGTC_790 1575-0012 79.1 µM -1.5564779215608 0.0941899247860625 no 3039 0.0597972443705081 4544 378741 YLR208W SEC13 SGTC_3063 1327-0034 4 µM -1.55789278785923 0.09399162160741 no 3040 0.0596293325794913 4410 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1211 1056-0033 32.3 µM -1.56375505848726 0.0931732666026811 no 3041 0.058937551082189 4570 6741922 SGTC_265 mycophenolic acid 32.932 µM -1.56418010220158 0.0931141371680513 no 3042 0.0588876393443495 4575 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_590 k048-0076 22.4 µM -1.56592836131025 0.0928712218597937 no 3043 0.0586826946715467 4540 6832814 SGTC_794 k038-0031 316 µM -1.57048175905567 0.0922407409585626 no 3044 0.0581515373972269 4513 6624242 SGTC_1770 st043884 66.3 µM -1.57207338819086 0.0920211068147849 no 3045 0.0579667661794458 4538 670149 SGTC_2625 euphol 100 µM -1.57281019756774 0.0919195632881856 no 3046 0.057881386842493 4519 6708538 A triterpene alcohol. SGTC_1977 st070720 65.3 µM -1.57485285877227 0.0916384874998671 no 3047 0.0576452060379233 4551 682188 SGTC_1775 st081588 35.1725 µM -1.57489669899704 0.0916324619531358 no 3048 0.0576401453726473 4516 1426443 YGL099W LSG1 SGTC_1754 st042065 16.137 µM -1.58152080088733 0.0907253930731851 no 3049 0.0568795033517402 4278 1126236 YIL048W NEO1 SGTC_2976 9009005 19.48 µM -1.58232284630291 0.0906160191442436 no 3050 0.0567879439085908 4514 2993148 SGTC_2206 7254556 146.969 µM -1.5845396776328 0.0903142217855853 no 3051 0.0565354799194908 4564 4398905 SGTC_1177 0983-0204 23.6 µM -1.58893763073974 0.0897176991162547 no 3052 0.0560372371633822 4563 766818 SGTC_1616 st002734 56.1 µM -1.592027790605 0.0893003163356165 no 3053 0.055689230177547 4516 4026101 SGTC_737 1950-0117 57.9 µM -1.59720888740409 0.0886037584306543 no 3054 0.0551095761513642 4549 5393513 SGTC_712 r015-0009 80.6 µM -1.60246643446235 0.0879010677273369 no 3055 0.0545262521091616 4574 6813872 YLR060W FRS1 SGTC_2813 7971799 71.43 µM -1.60277915730028 0.0878594024913602 no 3056 0.0544917100096208 4537 2234054 SGTC_2083 5306046 65.942 µM -1.6031410770135 0.0878112009614213 no 3057 0.0544517554296856 4552 539837 SGTC_3195 9113082 49.47 µM -1.6052666563578 0.0875285081079768 no 3058 0.0542175669132343 4532 17018038 SGTC_1265 0819-1001 68.8 µM -1.60634940788849 0.0873847681962754 no 3059 0.0540985801064399 4487 3106768 SGTC_3324 9138759 60.749 µM -1.60661263462561 0.0873498503573326 no 3060 0.0540696845850297 4556 45595710 SGTC_2863 9028737 58.44 µM -1.60716531571855 0.0872765694000619 no 3061 0.0540090541771525 4537 6460917 SGTC_1000 4048-0884 8.67 µM -1.60944888710447 0.0869742732311647 no 3062 0.0537591114402898 4545 13040088 SGTC_2650 prasterone 100 µM -1.61352425205606 0.0864367263424859 no 3063 0.0533153293429307 4581 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_3021 9087658 49.47 µM -1.61426945435286 0.0863387022334118 no 3064 0.0532344963105658 4574 25237042 SGTC_2986 9022445 71.43 µM -1.61845654290206 0.0857894767601419 no 3065 0.0527821224841836 4522 6459286 SGTC_2235 salicylic acid 500 µM -1.61858650773059 0.0857724710602992 no 3066 0.0527681300136209 4624 338 A COX inhibitor and kinase inhibitor. SGTC_2340 7987427 183.45 µM -1.62471250979444 0.0849737527519081 no 3067 0.0521119152789479 4548 2239331 SGTC_1502 4534-4282 27.7 µM -1.62981402020964 0.0843128747200778 no 3068 0.0515704048520972 4551 3278949 SGTC_1487 3970-0795 2.82 µM -1.63322726362646 0.083872862766937 no 3069 0.0512106039826984 4609 3765103 SGTC_1630 st005209 31.3 µM -1.63817242808949 0.0832384285204471 no 3070 0.0506928647606634 4554 3367314 SGTC_2202 7226349 200 µM -1.64338504830697 0.0825735946390485 no 3071 0.0501516458283241 4596 844334 SGTC_2219 9098279 200 µM -1.64519842013641 0.0823432510809392 no 3072 0.0499644496166529 4520 902349 SGTC_2664 lyso-paf C-16 73.48 µM -1.64543520449104 0.082313209298576 no 3073 0.0499400473116498 4550 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1476 4112-3294 3.34 µM -1.64574278240741 0.0822741979778243 no 3074 0.0499083634217208 4546 704369 SGTC_1712 st032288 53.4 µM -1.64757305456954 0.0820423452441953 no 3075 0.0497201567808684 4363 2883011 SGTC_2802 7925815 54.55 µM -1.64871133962693 0.0818983995926244 no 3076 0.0496033929585896 4547 1262923 SGTC_604 1000-0114 314 µM -1.64927274761774 0.0818274749857259 no 3077 0.0495458850771485 4570 1572745 SGTC_1995 st072814 61.1 µM -1.65269582461764 0.0813960271940301 no 3078 0.0491963923032273 4578 5769371 SGTC_2778 tioconazole 65.09 nM -1.65270501459663 0.0813948711945354 no 3079 0.0491954566723308 4462 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1119 parthenolide 318.541 nM -1.65314931539923 0.0813389977517712 no 3080 0.0491502393979219 4601 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_24 0417-1663 219 µM -1.65673849713143 0.0808886974468265 no 3081 0.0487861780981426 4587 4329390 SGTC_3119 9125183 49.47 µM -1.6623426650305 0.0801893631180775 no 3082 0.0482220439019816 4479 22695334 SGTC_1452 4194-0072 190 µM -1.66428271433326 0.0799483356129648 no 3083 0.0480279725553605 4611 1343545 SGTC_2647 atorvastatin 60.16 µM -1.6669347678786 0.0796197370556768 no 3084 0.0477636882893129 4564 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2698 st077697 67.5 µM -1.67078082733826 0.0791450139451429 no 3085 0.0473824884390957 4550 3154499 SGTC_1339 1486-1321 22.7 µM -1.67701214997622 0.0783804291291884 no 3086 0.04677005299135 4635 3469382 SGTC_1814 st052110 31.539 µM -1.68040259587287 0.0779667800256233 no 3087 0.046439505666645 4525 674163 SGTC_736 0958-0254 92.6 µM -1.68167143067376 0.0778124033405132 no 3088 0.0463162854482508 4621 6812352 SGTC_2182 6325192 200 µM -1.68357221700229 0.0775815725765066 no 3089 0.0461321859103664 4605 736248 SGTC_2300 7976697 71.57 µM -1.68451296814343 0.0774675206340801 no 3090 0.0460412876875352 4475 2236109 SGTC_715 0868-0130 184 µM -1.69920289849536 0.0757030653173606 no 3091 0.0446404802272664 4638 2876258 SGTC_3133 9127736 49.47 µM -1.69994902506841 0.0756142694145371 no 3092 0.0445702571115561 4588 27243420 SGTC_1219 1469-0211 33.1 µM -1.70004697908036 0.0756026178841874 no 3093 0.0445610445958098 4593 6822282 SGTC_1355 1499-0035 1.68 µM -1.70182005881211 0.0753919482576239 no 3094 0.0443945525439217 4591 1548538 SGTC_1343 1487-0095 224 µM -1.70760518926466 0.0747076952021506 no 3095 0.0438548124322736 4583 4560101 YGL055W OLE1 SGTC_2648 atorvastatin 78.68 µM -1.71018465911719 0.074404132837478 no 3096 0.0436158657975087 4592 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2215 7188065 200 µM -1.7107546593869 0.0743371801393214 no 3097 0.043563206379652 4644 940217 SGTC_769 0302-0231 76 µM -1.71633897241324 0.0736836732566644 no 3098 0.0430500096100437 4517 571869 YER009W NTF2 SGTC_3214 9129694 49.47 µM -1.71996866665357 0.0732612674614975 no 3099 0.0427190686612681 4573 17158655 SGTC_3253 9135987 49.47 µM -1.72654653487482 0.0725004918405828 no 3100 0.0421245675224609 4603 4182430 SGTC_2452 5863136 48.41 µM -1.72718366915797 0.072427125563094 no 3101 0.0420673414046668 4561 2184096 SGTC_3004 9076122 71.4286 µM -1.73516381736735 0.0715130194879078 no 3102 0.0413558966531501 4592 44782551 SGTC_2357 9067248 200 µM -1.74209315678576 0.0707264849263266 no 3103 0.0407460724211704 4561 9150235 SGTC_3015 9080845 49.47 µM -1.74265313979221 0.0706632139012194 no 3104 0.040697110844687 4624 5296973 SGTC_3108 9121785 49.47 µM -1.74965340176529 0.0698759386938669 no 3105 0.0400890695004102 4494 17140271 SGTC_813 k007-0158 173 µM -1.75372060980391 0.0694216357479301 no 3106 0.0397391961381894 4600 6523916 SGTC_3081 9117243 49.47 µM -1.75610804557607 0.0691560232034637 no 3107 0.0395349808069926 4571 45595589 SGTC_263 alizarin 107.927 µM -1.7574211164112 0.0690102725473644 no 3108 0.0394230283217842 4637 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_3136 9095672 49.47 µM -1.7587928406271 0.0688582643465069 no 3109 0.0393063506330716 4485 17217380 SGTC_2507 purpurin 79.67 µM -1.76200295882094 0.0685035427041182 no 3110 0.0390343987850418 4596 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_312 4092-0653 6.84 µM -1.76649423618694 0.0680096194408094 no 3111 0.0386564838551617 4509 1148278 SGTC_2913 7966556 36.57 µM -1.76870318044645 0.0677677041619259 no 3112 0.0384717106284466 4519 2976516 SGTC_1270 0831-1170 17.3 µM -1.77022321035711 0.0676016226249147 no 3113 0.0383449821334038 4632 6764716 SGTC_1644 st010134 20.9 µM -1.77438441535524 0.0671485697757595 no 3114 0.0379997929641885 4608 3818134 SGTC_1216 1165-0504 9.65 µM -1.77481867852692 0.0671014248173559 no 3115 0.0379639155884285 4650 6304004 SGTC_29 0299-0004 12.984 µM -1.77506925458761 0.0670742331507302 no 3116 0.0379432264067356 4549 16871 A napthoquinone isolated from Swertia calycina. SGTC_916 4466-0038 42 nM -1.77657270802251 0.0669112623865668 no 3117 0.0378192846661001 4649 5722064 YGL116W CDC20 SGTC_2029 5175081 200 µM -1.77789441778358 0.0667682453639572 no 3118 0.0377105986100888 4569 1380876 SGTC_371 0195-0006 7.36 µM -1.77946794329721 0.0665982889022405 no 3119 0.0375815379857655 4471 3928593 SGTC_2263 7948595 193.29 µM -1.78301724389088 0.066216158644646 no 3120 0.037291748176116 4638 2971371 SGTC_373 0844-0104 25.9 µM -1.78409695771862 0.0661002503490347 no 3121 0.0372039557777856 4628 5375804 SGTC_1634 st006576 41 µM -1.78595762093816 0.0659008752997498 no 3122 0.037053060081788 4597 3915356 SGTC_1016 4226-1401 38 µM -1.7866368882565 0.0658282062197979 no 3123 0.0369980977918672 4628 2901613 SGTC_1797 st048695 56.8 µM -1.79024519232925 0.0654432249767124 no 3124 0.0367072514371192 4598 592262 YIL048W NEO1 SGTC_2307 7538926 6.34 µM -1.79090966537116 0.0653725210450673 no 3125 0.0366538962046343 4575 96582 SGTC_2770 toltrazuril 17.5 µM -1.79169546365277 0.0652889838622925 no 3126 0.036590880800591 4552 68591 Kills coccidiodes. SGTC_3164 9100705 49.47 µM -1.79428858755889 0.0650138997567456 no 3127 0.0363835593573639 4644 17174235 SGTC_551 k048-0028 34.9 µM -1.79954464836599 0.0644590861682552 no 3128 0.0359662839322329 4586 6836383 SGTC_2065 5221596 34.26 µM -1.8022184797163 0.0641782599728493 no 3129 0.0357555191750512 4591 788581 SGTC_2068 5226020 147 µM -1.80442874276155 0.0639468400344187 no 3130 0.0355820602697642 4638 1810509 SGTC_2229 7354935 190 µM -1.80895497773794 0.0634749577648603 no 3131 0.0352289990735083 4617 318112 SGTC_1791 st048313 56.1 µM -1.81066982769769 0.0632968857605156 no 3132 0.0350959880314418 4653 1204976 SGTC_2046 4110841 106 µM -1.81356803391413 0.0629968170698341 no 3133 0.0348721277676307 4642 44119630 YMR134W ERG29 SGTC_2210 7115885 190.385 µM -1.81749266351546 0.0625922442245729 no 3134 0.0345708553270631 4704 2927039 SGTC_2586 curcumin 80 µM -1.81773561210149 0.0625672664435252 no 3135 0.0345522759772977 4529 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_1926 methyl fluorone black 53.6 µM -1.81877547528704 0.0624604448884059 no 3136 0.0344728457183484 4276 72721 Reacts with homocysteine. SGTC_1480 1070-0044 41.2 µM -1.83082954575219 0.06123252559808 no 3137 0.0335629944443975 4674 3124987 SGTC_3173 9105693 49.47 µM -1.83376401525997 0.0609364720238568 no 3138 0.033344515742492 4614 17096658 SGTC_1861 st057647 17.4 µM -1.8382219202647 0.0604888644317132 no 3139 0.0330148555032915 4653 688668 SGTC_486 niguldipine 82 µM -1.83846646707201 0.0604643847008896 no 3140 0.0329968493505748 4704 1236 A calcium channel blocker. SGTC_1583 clindamycin 39.6 µM -1.84057976040916 0.0602531617081802 no 3141 0.0328415829895408 4639 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1165 k072-0275 30.3 µM -1.84684357786835 0.0596304872417122 no 3142 0.0323849070088275 4634 6153523 YGL055W OLE1 SGTC_2741 miltefosine 3.04 µM -1.8495218798262 0.0593657860962412 no 3143 0.0321912457074411 4690 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_3060 1327-0027 12.5 µM -1.8530371969474 0.0590197603935953 no 3144 0.0319385136738861 4563 16000455 YPR107C YTH1 SGTC_2096 5468907 200 µM -1.86341331669943 0.058007623306035 no 3145 0.0312020689464472 4660 759785 SGTC_2060 5238662 140 µM -1.8654135969379 0.0578140838149818 no 3146 0.031061726472268 4616 790130 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.86758868113896 0.0576042074926728 no 3147 0.0309097126638909 4627 756377 SGTC_2145 5634607 200 µM -1.87147367402216 0.057230831602045 no 3148 0.0306397277575734 4657 308662 SGTC_1736 st036774 51 µM -1.87229440810865 0.0571521973469647 no 3149 0.0305829419872032 4669 1272247 SGTC_2671 danthron 100 µM -1.87494823859932 0.056898516698195 no 3150 0.0303999224120264 4640 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1884 5633444 25 µM -1.87616538578671 0.0567824661324248 no 3151 0.0303162867529766 4596 5724239 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.87841312352292 0.0565686426259427 no 3152 0.0301623358000533 4614 4000243 SGTC_3186 9110464 49.47 µM -1.88235099376142 0.0561955695686361 no 3153 0.0298941875311919 4643 17018021 SGTC_2736 butenafine 14.65 µM -1.8869690549387 0.0557605299269227 no 3154 0.029582243973016 4603 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2666 tannic acid 100 µM -1.89055343069173 0.0554247028991646 no 3155 0.0293419908767584 4632 16134267 A thiamine antagonist. SGTC_3263 9137018 49.47 µM -1.89466830467788 0.0550411436808084 no 3156 0.0290681796734827 4616 43844957 SGTC_488 nitrendipine 139 µM -1.8998774571819 0.0545585951254133 no 3157 0.0287246014989776 4669 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2064 5220758 200 µM -1.90392833193455 0.0541856607252237 no 3158 0.0284597593269766 4663 788518 SGTC_2511 berberine 10.47 µM -1.90844737154125 0.0537720093730634 no 3159 0.0281667095685755 4645 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1564 D-Arginine 115 µM -1.91745513246727 0.0529549449602486 no 3160 0.0275900679157914 4645 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1030 k029-0042 36.7 µM -1.91940487406514 0.0527793932856247 no 3161 0.0274665572911933 4654 6080581 SGTC_256 clotrimazole 625 nM -1.92483112718648 0.0522932518906041 no 3162 0.0271252442347415 4616 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_3199 9111318 49.47 µM -1.93053730628315 0.0517858742940817 no 3163 0.0267701487052312 4581 8548020 SGTC_1403 3909-7815 62.9 µM -1.93054345244373 0.0517853299116533 no 3164 0.0267697683326469 4680 6615483 SGTC_2618 avocadyne 43.43 µM -1.9321040046697 0.0516472546167881 no 3165 0.0266733350786907 4621 3015189 SGTC_500 h-89 112 µM -1.93868451105838 0.0510682378155338 no 3166 0.0262698829121325 4643 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_3343 9148379 18.9835 µM -1.93877638129472 0.051060190898395 no 3167 0.0262642866399016 4680 1955036 SGTC_1573 oleylamine 1.06 µM -1.94449041395312 0.0505616787437464 no 3168 0.0259181701453054 4653 5356789 An amine of the fatty acid oleic acid. SGTC_348 k064-0012 10.7 µM -1.94952637039308 0.0501255456281343 no 3169 0.0256162983761743 4648 5066323 SGTC_2627 acetyl isogambogic acid 100 µM -1.95165620696269 0.0499419984096282 no 3170 0.0254895176109006 4664 6857789 A caspase activator and apoptosis inducer. SGTC_1749 st037932 54.2 µM -1.95311231369416 0.0498168213474229 no 3171 0.0254031440953482 4646 594497 SGTC_2061 5245884 80.95 µM -1.96140646642177 0.0491085642512383 no 3172 0.0249158131380987 4658 573863 SGTC_1680 diphenhydramine 100 µM -1.96281134521601 0.0489893987922105 no 3173 0.024834049523723 4614 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_2498 4'-Methoxychalcone 54.63 µM -1.9661699526463 0.0487054492395332 no 3174 0.0246394910473581 4669 641818 YHR062C RPP1 SGTC_1941 st076221 61.8 µM -1.97203016770958 0.0482131558123627 no 3175 0.0243030813876367 4581 2828568 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.97255014340753 0.0481696676987258 no 3176 0.024273419014458 4655 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1079 idarubicin 2.36 µM -1.98081685796213 0.0474824889534813 no 3177 0.0238059077935087 4697 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_919 tnp00227 403.569 nM -1.98927088069106 0.0467878854741001 no 3178 0.0233356559863455 4638 1269246 A methoxyflavone. YNL221C POP1 SGTC_1506 4226-2149 212 µM -1.99296146413079 0.0464872249612218 no 3179 0.0231328334925965 4683 991114 SGTC_2273 7815444 169.05 µM -1.99437719493859 0.0463723020584793 no 3180 0.023055424406421 4616 2824616 SGTC_2309 7664088 163.95 µM -2.00509084174107 0.0455099913621698 no 3181 0.0224766681895643 4654 704922 SGTC_2149 5554786 194.827 µM -2.00603434215083 0.0454346735923615 no 3182 0.0224262920459064 4705 745063 YPR165W RHO1 SGTC_1078 idebenone 36.1 µM -2.00687768317286 0.0453674362266974 no 3183 0.0223813443230057 4712 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_165 k038-0023 64.381 µM -2.00707313422954 0.0453518648561552 no 3184 0.0223709381797996 4648 46368543 SGTC_2486 5283202 22.39 µM -2.00720294718452 0.0453415251769083 no 3185 0.02236402897523 4684 1377751 SGTC_2946 9065502 71.43 µM -2.00929123512737 0.0451754522567373 no 3186 0.0222531284454424 4593 16489101 SGTC_1140 3229-1848 2.98 µM -2.01087004915882 0.0450502208680883 no 3187 0.0221695923415973 4682 2849525 SGTC_1933 st074711 15.9 µM -2.02494718726279 0.0439459342271983 no 3188 0.0214363937574568 4685 17250958 SGTC_470 aa-861 153 µM -2.02709658011211 0.0437792617282604 no 3189 0.0213262682807054 4654 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_76 0433-0009 400.328 µM -2.0346931378783 0.0431942766421605 no 3190 0.0209408795505209 4729 2841569 SGTC_1715 st032160 10.2275 µM -2.03966179424277 0.0428150839460264 no 3191 0.0206920113536838 4614 5289825 SGTC_746 1095-0025 46.6 µM -2.04402224277772 0.0424845286212639 no 3192 0.0204756749178511 4704 6749286 SGTC_1556 plumbagin 1.48 µM -2.05323827891543 0.04179267333772 no 3193 0.0200247368033459 4635 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1553 gossypol 38.6 µM -2.05603102449231 0.0415848303555349 no 3194 0.0198897629330441 4680 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1513 0337-0559 19 µM -2.05943998305708 0.0413322630768418 no 3195 0.0197260544262935 4673 775073 SGTC_2951 9072950 58.06 µM -2.0691777406417 0.0406176420358166 no 3196 0.0192647053570861 4644 16488155 SGTC_1067 clotrimazole 1.36 µM -2.07393366731795 0.0402722835806775 no 3197 0.0190427358777476 4740 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3061 glucosamine 200 µM -2.07820822327208 0.0399639192540477 no 3198 0.0188450925151699 4647 91431 and experimental redox chemotherapeutic SGTC_2196 6573537 42.6665 µM -2.08332404097294 0.0395973921560606 no 3199 0.0186108484048068 4719 2903087 SGTC_217 ketoconazole 989 nM -2.08446961688967 0.0395156921715238 no 3200 0.0185587355617421 4541 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1047 2043-3044 82 µM -2.08604824753083 0.0394033323782012 no 3201 0.0184871264392677 4670 669592 SGTC_1239 0337-0584 35.4 µM -2.08900212326068 0.0391937871244512 no 3202 0.018353766020112 4708 914301 YML130C ERO1 SGTC_1072 oxiconazole 14.9 nM -2.0910122392105 0.0390517106108554 no 3203 0.0182634834237162 4668 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_9 0092-0002 10.449 µM -2.09730291183978 0.0386097884560987 no 3204 0.0179833846361508 4704 759368 SGTC_2448 5185112 27.17 µM -2.1001363527426 0.0384120735724584 no 3205 0.0178584241374454 4697 5718189 SGTC_1434 4073-0095 163 µM -2.10560388913306 0.0380328869351408 no 3206 0.0176193872777322 4723 24133745 SGTC_975 1335-0046 28.5 µM -2.1068450852341 0.0379472336957258 no 3207 0.0175655049968409 4707 16486740 SGTC_2175 5807670 165.306 µM -2.11378274619786 0.037471369292126 no 3208 0.0172669136394782 4686 241186 SGTC_2127 5253358 187.912 µM -2.11715304438644 0.0372419605664244 no 3209 0.0171234305182397 4657 20612 SGTC_619 1652-1634 108 µM -2.12358595030749 0.0368072726436579 no 3210 0.0168523907005122 4680 5400454 SGTC_2268 7933382 153.85 µM -2.15247240639761 0.0349062015992706 no 3211 0.015680083147899 4720 935025 YOR257W CDC31 SGTC_869 0564-0080 44.1 µM -2.15605468048012 0.0346761661405203 no 3212 0.0155396978454709 4709 6843321 SGTC_2914 7968218 45.32 µM -2.1563603489793 0.0346565954441531 no 3213 0.0155277691457663 4696 2977111 SGTC_2157 5649910 96.377 µM -2.15642508740746 0.0346524516732627 no 3214 0.0155252437402285 4704 2858091 SGTC_1931 st074438 57.1 µM -2.15806678160508 0.0345475061989043 no 3215 0.0154613199944327 4709 2787313 SGTC_2003 4023581 200 µM -2.17432644000759 0.0335221390726803 no 3216 0.0148403140611096 4699 16641307 SGTC_2906 7926292 26.41 µM -2.17754852994798 0.0333219512933783 no 3217 0.0147198325157229 4697 2966319 SGTC_1422 4031-0024 15.5 µM -2.19462195759249 0.032277548400226 no 3218 0.0140953635628914 4706 782427 SGTC_2248 tofa 1.1 µM -2.19686249779523 0.0321425189721375 no 3219 0.0140151339585216 4739 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1346 1488-2224 62.4 µM -2.20490751903996 0.0316615120343373 no 3220 0.013730292390836 4727 3722427 SGTC_335 4077-0256 27.6 µM -2.21833063062538 0.0308722027124658 no 3221 0.0132661485716627 4630 3121989 SGTC_2186 6124449 200 µM -2.22395651271974 0.0305462668003529 no 3222 0.0130756851235548 4734 3834182 YLR033W RSC58 SGTC_1304 1165-0502 251 µM -2.23184415069356 0.0300940999361882 no 3223 0.0128126325802197 4731 767425 SGTC_1799 st045822 46.1415 µM -2.23476052184664 0.0299283274035938 no 3224 0.0127165374554427 4718 3674992 SGTC_2136 5328288 199.296 µM -2.23977908750854 0.02964483505642 no 3225 0.0125526340885705 4697 262395 SGTC_597 k018-0003 82.8 µM -2.2422252428482 0.0295074647988295 no 3226 0.012473409244351 4761 6786234 SGTC_255 tunicamycin 200.472 nM -2.24693544512916 0.0292444393256098 no 3227 0.0123220765219122 4691 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1360 1598-0022 39.8 µM -2.2606992934618 0.0284869812622058 no 3228 0.0118889421316915 4741 761525 SGTC_2651 TUB2.036 5 µM -2.26661236062776 0.0281666200884939 no 3229 0.0117069581668094 4618 15992207 YFL037W TUB2 SGTC_1844 rapamycin 4 nM -2.2693200056766 0.0280209282085154 no 3230 0.0116244364098713 4583 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_2038 4100038 30.985 µM -2.27072236623147 0.0279457175841378 no 3231 0.0115818950863751 4708 3596803 SGTC_2752 diclazuril 33.15 µM -2.27475076753556 0.0277306033052621 no 3232 0.0114604425657662 4657 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2920 7982904 15.77 µM -2.27829367870909 0.0275425560172659 no 3233 0.0113545430191139 4715 6456808 SGTC_2858 9025781 8.96 µM -2.2798305128035 0.0274613166030987 no 3234 0.0113088712822176 4568 4894980 YPL153C RAD53 SGTC_955 1216-0110 33 µM -2.28171907565423 0.027361757983254 no 3235 0.0112529655632175 4709 3619719 SGTC_2689 tacrolimus 100 µM -2.28516884688657 0.0271806748875941 no 3236 0.0111514645691013 4713 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_1531 st059297 52.4 µM -2.29393656649041 0.0267249410249738 no 3237 0.010897071322436 4747 7566702 SGTC_2174 5790901 200 µM -2.29831782468184 0.0264996112881916 no 3238 0.010771853342882 4716 786020 SGTC_2050 5263056 171 µM -2.3102787242401 0.0258925273452141 no 3239 0.0104363640215814 4713 763468 YGL055W OLE1 SGTC_1176 0848-0131 83.3 µM -2.31058515714731 0.0258771282943686 no 3240 0.0104278899386468 4761 6769040 SGTC_2675 theaflavin digallate 100 µM -2.31509433340084 0.0256514150802682 no 3241 0.0103038850394221 4693 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -2.32161500523215 0.0253279304016567 no 3242 0.01012683759892 4743 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_562 3772-2733 112 µM -2.32788873467506 0.0250199291159439 no 3243 0.00995900629595384 4713 2876874 YIL048W NEO1 SGTC_416 estradiol valerate 100 µM -2.33114514089967 0.0248613015656573 no 3244 0.00987285385277627 4739 13791 A steroid. SGTC_3311 9131146 2.8755 µM -2.33392561819748 0.0247265260289616 no 3245 0.00979980852837761 4731 4900406 YPR165W RHO1 SGTC_304 1310-0298 97 µM -2.33400047598467 0.0247229060054435 no 3246 0.0097978484982234 4527 1550234 SGTC_1886 st057356 49.9 µM -2.35456756387901 0.0237450116974843 no 3247 0.00927213608524985 4739 24207747 SGTC_2519 cryptotanshinone 88.04 µM -2.36805809284139 0.023121409369261 no 3248 0.00894086395342565 4739 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1522 st012842 45.6 µM -2.36922250885907 0.0230682365257993 no 3249 0.00891276286645569 4634 3491067 YOR116C RPO31 SGTC_1658 st012944 20 µM -2.37504016128885 0.0228041145585535 no 3250 0.00877352043109305 4632 24207260 SGTC_718 1130-0073 349 µM -2.41149175585243 0.021206577347983 no 3251 0.0079437055136238 4760 6740020 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -2.41556253652058 0.0210341931206044 no 3252 0.00785546217357551 4742 2374 Ca(2+)-ATPase inhibitor. SGTC_846 0335-0850 148 µM -2.43400863521255 0.0202678484893975 no 3253 0.00746631942082484 4753 6819598 SGTC_649 1123-0311 367 µM -2.44281537835727 0.0199104016563274 no 3254 0.00728659514674086 4691 693629 YIL048W NEO1 SGTC_2456 5770359 74.46 µM -2.44391457397364 0.0198661654198534 no 3255 0.00726443313928223 4740 3118787 SGTC_2115 tiliquinol 12.7705 µM -2.44691814693162 0.0197457141790435 no 3256 0.00720417783563924 4737 71208 A bioactive hydroxyquinoline. SGTC_891 0929-0073 133 µM -2.44904656555583 0.019660734744586 no 3257 0.00716174645686469 4773 5603632 SGTC_402 epigallocatechin gallate 10 µM -2.45051219060629 0.0196023987672642 no 3258 0.00713265660151852 4748 65064 An antioxidant. SGTC_2518 prenyletin 46.28 µM -2.4545969633933 0.0194405885271862 no 3259 0.00705213106473644 4768 3873459 A coumarin with calcium channel inhibitory activity. SGTC_1010 4112-3296 15.2 µM -2.45484110140662 0.0194309535210981 no 3260 0.00704734373682238 4755 704384 SGTC_1436 4092-1007 8.32 µM -2.45761425201551 0.0193217944606092 no 3261 0.00699316571978906 4769 2881121 SGTC_1656 st012921 11 µM -2.46485005962632 0.0190394235635463 no 3262 0.00685352987905186 4712 6732821 SGTC_2482 5981709 142.65 µM -2.46664491038436 0.018969926812958 no 3263 0.00681927654265281 4735 877755 SGTC_577 r071-0003 38.6 µM -2.47743797126413 0.0185565526806417 no 3264 0.00661647040680585 4749 4568517 YMR134W ERG29 SGTC_2449 5812982 45.77 µM -2.48178796966663 0.018392129542068 no 3265 0.00653625175602357 4715 776185 SGTC_511 blebbistatin 171 µM -2.48194638315758 0.0183861652533357 no 3266 0.00653334674327894 4765 3476986 A myosin inhibitor. SGTC_2504 purpurogallin 52.29 µM -2.48261762355562 0.0183609112410325 no 3267 0.00652105009247754 4727 5281571 An antioxidant. SGTC_1718 roemerine 11.9335 µM -2.50597550181722 0.0175003415582327 no 3268 0.00610570401494915 4455 235224 An aporphine alkaloid with mutagenic activity. SGTC_1800 st050079 29.0735 µM -2.51113284978747 0.0173150422588366 no 3269 0.00601721989739371 4658 3645560 SGTC_3219 9131112 49.47 µM -2.51144113746731 0.0173040190171979 no 3270 0.00601196682208534 4656 17612988 YMR079W SEC14 SGTC_1679 SEC14.276 6.7 µM -2.51561228250492 0.0171554623485156 no 3271 0.00594129104297164 4715 1005053 YMR079W SEC14 SGTC_3303 9125618 40.5795 µM -2.52467555822746 0.0168364239028688 no 3272 0.00579025734393793 4752 22695467 SGTC_1701 st028638 40.4 µM -2.53219042819499 0.0165757523604572 no 3273 0.00566762062813024 4769 3490878 SGTC_2271 7849410 118.62 µM -2.54347989899742 0.0161906449824989 no 3274 0.00548771858769673 4726 972430 SGTC_1146 3579-1023 7 µM -2.55813053765668 0.0157023299266509 no 3275 0.00526182900889559 4765 X1146 SGTC_151 3013-0144 2.285 µM -2.56653376432251 0.0154279881654348 no 3276 0.00513603120916225 4578 906558 YHR107C CDC12 SGTC_340 k038-0059 454 µM -2.5710442593944 0.0152824376643645 no 3277 0.00506961840195462 4772 23733424 SGTC_2716 st080858 38.6235 µM -2.57795196345536 0.015061817484575 no 3278 0.0049693906624451 4762 5296050 SGTC_968 1309-0633 340 µM -2.59306791428642 0.0145885704100386 no 3279 0.00475619921465244 4774 3761976 SGTC_252 miconazole 1.30953 nM -2.60545438397583 0.0142103706786073 no 3280 0.00458762450965313 4724 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1892 st058411 7.36 µM -2.61002559580222 0.0140729460617178 no 3281 0.00452677241706638 4763 3934738 SGTC_374 0880-0231 82.3 µM -2.61005116551731 0.014072180590502 no 3282 0.00452643406897606 4690 6833587 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -2.61687417933196 0.013869200595728 no 3283 0.00443695222293451 4761 616764 SGTC_858 0438-0351 2.77 µM -2.62281874102498 0.0136944170091959 no 3284 0.00436028268718823 4772 2799119 SGTC_2009 4012297 12.05 µM -2.63234559367782 0.0134182691551564 no 3285 0.00423987788026274 4740 45595307 SGTC_3025 9087895 49.47 µM -2.64056469023261 0.0131839049147801 no 3286 0.00413839948381867 4772 17173641 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -2.64213836467388 0.0131394379419329 no 3287 0.00411921960579221 4729 676296 Flavone; oxidizing agent. SGTC_1281 0884-0031 11.8 µM -2.64573548164667 0.0130382814647425 no 3288 0.00407567649794824 4777 1548255 SGTC_3111 9122088 49.47 µM -2.67640997758153 0.012202679689967 no 3289 0.0037207777034111 4772 16876704 SGTC_1950 st077106 7.18 µM -2.67762209447966 0.0121706362091292 no 3290 0.00370734116116974 4739 13831864 SGTC_1359 1582-0056 520 nM -2.68215046547382 0.0120515686754003 no 3291 0.00365752751023078 4785 3661189 SGTC_3059 1327-0034 3 µM -2.69440437922927 0.0117344195037886 no 3292 0.00352572781226967 4703 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_352 k048-0007 5.11 µM -2.7056773377871 0.0114490815039589 no 3293 0.00340826209266692 4733 6811911 SGTC_608 k048-0125 159 µM -2.71754007767567 0.0111553426430447 no 3294 0.00328845948055486 4785 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2968 9090663 33.37 µM -2.72987887284292 0.0108567902201375 no 3295 0.00316787999260486 4752 25236811 SGTC_2466 5983409 37.09 µM -2.73033848114779 0.0108458050722577 no 3296 0.00316346639806835 4789 2879657 SGTC_2640 pentamidine 10.38 µM -2.75460746660977 0.0102793254500219 no 3297 0.00293812941557958 4755 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1917 st066507 28.5 µM -2.76108786506337 0.0101324968921993 no 3298 0.00288045876268579 4700 3156428 SGTC_473 2-arachidonoylglycerol 10 µM -2.76542517873401 0.0100352501224912 no 3299 0.00284243224193828 4704 5282280 An endocannabinoid. SGTC_1088 bifonazole 369 nM -2.79062328860299 0.00948624002643647 no 3300 0.0026303330366447 4782 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_2595 hexamethylquercetagetin 100 µM -2.795660137271 0.00937970401155108 no 3301 0.00258969175889044 4751 386331 SGTC_1283 0922-0125 16.4 µM -2.80269609800059 0.00923263683089793 no 3302 0.00253386987240319 4773 3360884 SGTC_3345 9148410 3.559 µM -2.80602484404151 0.00916376468725355 no 3303 0.00250784125093945 4761 4903596 SGTC_2953 9074162 66.49 µM -2.80978961807348 0.00908641342818245 no 3304 0.00247869468370696 4761 16451992 SGTC_2777 climbazole 1.536 µM -2.8100426346153 0.00908123549964536 no 3305 0.00247674688077477 4644 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1952 st077036 64.1 µM -2.81596550632074 0.00896076119388111 no 3306 0.00243154438431299 4775 2937007 SGTC_2469 5655019 90.81 µM -2.83497939725024 0.00858341959942862 no 3307 0.00229143205386153 4789 2788239 SGTC_2520 obtusaquinone 4.71 µM -2.85290668833012 0.00824048381700685 no 3308 0.00216606700942978 4787 5967872 SGTC_457 grayanotoxin iii 135 µM -2.855564370903 0.00819068233555824 no 3309 0.0021480206648185 4664 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_1186 1319-0216 26 µM -2.88030119308057 0.00773968674785794 no 3310 0.00198647713619903 4797 4565136 SGTC_1086 cerivastatin 2.18 µM -2.89191735064348 0.00753555067078931 no 3311 0.00191449329887525 4791 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_367 0335-0881 7.1 µM -2.95244715583131 0.00654673467696612 no 3312 0.00157633013270443 4753 23828853 SGTC_268 camptothecin 39.6153 µM -3.005291614932 0.00577916605176352 no 3313 0.00132663166896857 4770 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_3151 9099821 49.47 µM -3.00876416208049 0.00573164401514191 no 3314 0.00131156325446048 4775 17174189 SGTC_293 4049-0273 38.5 µM -3.03815735962275 0.00534309001946966 no 3315 0.00119014811547243 4763 1380311 SGTC_1916 st067606 49.2 µM -3.05846098711979 0.00508854897445449 no 3316 0.00111238522539273 4750 19590279 SGTC_1827 berberine 7.24 µM -3.0785486143609 0.0048473975492951 no 3317 0.00104005794053836 4765 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2634 4'-methoxyflavone 100 µM -3.08373638445612 0.00478679741263621 no 3318 0.00102209320553069 4775 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_612 0302-0167 22.4 µM -3.10804261316849 0.00451177223709849 no 3319 0.000941654554177375 4786 235821 SGTC_1061 3448-9325 110 µM -3.10846719592489 0.0045070961150487 no 3320 0.000940302609316949 4787 723482 SGTC_444 curcumin 90.4 µM -3.15061889682489 0.00406385504066626 no 3321 0.000814624639896004 4745 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3038 9091290 49.47 µM -3.16359426171676 0.00393549617905967 no 3322 0.000779169393895004 4791 25236843 SGTC_660 4031-1742 102 µM -3.17482798833545 0.00382731263747713 no 3323 0.000749626735068609 4754 6738706 SGTC_3266 9136860 49.47 µM -3.17507379288345 0.00382497557495187 no 3324 0.000748992006859833 4660 4871271 YPR165W RHO1 SGTC_867 0518-0118 155 µM -3.19946150804686 0.00359936444222251 no 3325 0.000688422856917574 4791 6848158 SGTC_1673 st016611 27.3 µM -3.20700648832768 0.00353202603102993 no 3326 0.000670619853638192 4785 5226799 SGTC_2612 dictamnine 15.46 µM -3.21380937621947 0.00347228283346563 no 3327 0.000654933010285164 4772 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1156 4092-0367 4.88 µM -3.21556225139935 0.00345703683405609 no 3328 0.000650946274091022 4800 1357585 SGTC_864 0469-0573 172 µM -3.21985005213959 0.00341999595069269 no 3329 0.000641288323949022 4793 689425 SGTC_2508 celastrol 40.54 µM -3.26428957462558 0.00305658207625063 no 3330 0.000548694721566915 4794 122724 Celastrol is a natural product and antioxidant. SGTC_1161 k007-0610 110 µM -3.26616277764969 0.00304205742746975 no 3331 0.000545077822742208 4770 5843850 SGTC_2401 5128683 200 µM -3.27469816502922 0.0029766587309194 no 3332 0.000528874615741849 4781 708373 SGTC_1818 st052136 56.3 µM -3.3177242706791 0.00266588601048514 no 3333 0.000453770126105475 4702 674169 SGTC_659 k018-0002 107 µM -3.31887838810003 0.0026579691739865 no 3334 0.000451898904730753 4789 6797879 YHR007C ERG11 SGTC_77 0828-0286 12.516 µM -3.35312165660367 0.0024325235682419 no 3335 0.000399527879816055 4767 745345 SGTC_2350 9023895 38.85 µM -3.38007399141135 0.00226740601575655 no 3336 0.000362331591652279 4779 2997209 SGTC_2437 5741531 144.16 µM -3.38683582057817 0.00222760692695149 no 3337 0.000353518427417346 4800 2262990 SGTC_2502 avocadyne acetate 18.59 µM -3.42947821542174 0.0019908711407667 no 3338 0.000302371488528189 4798 3952079 SGTC_1707 st032323 6.317 µM -3.46869358392429 0.00179357411015487 no 3339 0.00026149779205224 4734 3132057 YMR211W DML1 SGTC_2485 5633444 17.78 µM -3.50496997377121 0.00162707648271306 no 3340 0.000228329391460617 4794 5724239 SGTC_2443 5493264 126.67 µM -3.58116852491252 0.00132229534883494 no 3341 0.000171030459351672 4806 5340055 SGTC_1787 fluconazole 80 µM -3.58899217117359 0.00129415743647218 no 3342 0.000165979404295299 4627 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2301 7769476 200 µM -3.6093236109578 0.00122357599077048 no 3343 0.000153498219341969 4795 977820 SGTC_3142 9086498 49.47 µM -3.70714948338699 0.000930700652030083 yes 3344 0.00010480261596997 4766 25236367 SGTC_617 3770-0098 35 µM -3.72590737644084 0.000882505923157673 yes 3345 9.73069317378624e-05 4794 5962639 SGTC_2399 5884133 200 µM -3.92697712149447 0.00049195813737434 yes 3346 4.30100799690078e-05 4797 722445 SGTC_3010 9080089 71.4286 µM -3.98495616416135 0.000413633875781472 yes 3347 3.37462920035095e-05 4806 17027233 SGTC_2021 4019055 173 µM -4.00071829502638 0.000394436004792423 yes 3348 3.15752502224631e-05 4771 44827708 YER133W GLC7 SGTC_1241 0364-0022 50.8 µM -4.14365780417831 0.000254433895849424 yes 3349 1.7090483610115e-05 4810 4563895 SGTC_339 3091-4833 71.4 µM -4.25186609040204 0.000180950027479129 yes 3350 1.05998307168847e-05 4778 3240077 SGTC_2398 5228213 48.84 µM -4.4718706507626 8.83650415778775e-05 yes 3351 3.87691624468421e-06 4806 80771 YMR134W ERG29 SGTC_3007 9078383 71.4286 µM -4.58064388097303 6.1269781295688e-05 yes 3352 2.31773290902315e-06 4809 6496995 SGTC_431 k089-0097 107 µM -5.25581022451563 5.29291554027637e-06 yes 3353 7.36870999579481e-08 4761 5499420 SGTC_453 enantio-paf c16 10 µM -5.26460878976421 5.11638123686779e-06 yes 3354 7.02440947801913e-08 4678 13871343 A lipid and platelet activating factor SGTC_2896 9052656 71.43 µM -6.04099438796332 2.0898467804107e-07 yes 3355 7.65836535979891e-10 4732 6469436 SGTC_1250 0485-0349 40.2 µM -6.44601825440045 3.35369750571421e-08 yes 3356 5.74134189850885e-11 4809 6842794 YDL195W SEC31