SGTCid condition conc unit RGD1|YBR260C.score RGD1|YBR260C.strain.pval RGD1|YBR260C.strain.significant RGD1|YBR260C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_58 0957-0393 9 µM 23.0306885842406 2.89592063909172e-147 yes 1 1.14855528882061e-117 5 6997992 SGTC_2399 5884133 200 µM 22.8644529100135 3.52675667298e-145 yes 2 5.24797144525926e-116 1 722445 SGTC_663 1486-0733 13.9 µM 15.1660263214118 4.28764194210859e-65 yes 3 2.96818275908161e-52 6 722445 YPR165W RHO1 SGTC_2007 4011539 71.82 µM 12.9194374222292 8.31306810515454e-48 yes 4 1.74844426004835e-38 8 45595301 SGTC_2009 4012297 12.05 µM 12.4924801163407 7.84976241636311e-45 yes 5 4.10276053603863e-36 7 45595307 SGTC_16 erodoxin 22.806 µM 11.938854814636 4.02810830798314e-41 yes 6 3.71191322082028e-33 8 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_22 0964-0034 14.468 µM 9.73775789836793 5.13508696158451e-28 yes 7 1.04047452254303e-22 7 138402 SGTC_2582 agaric acid 100 µM 9.23267448130965 2.22502512430325e-25 yes 8 1.31978640513241e-20 81 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_255 tunicamycin 200.472 nM 7.90266650649633 4.27076577116282e-19 yes 9 1.36499644822543e-15 18 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2149 5554786 194.827 µM 7.73695614384424 2.22029095396423e-18 yes 10 5.09125815050338e-15 6 745063 YPR165W RHO1 SGTC_2272 7805186 180 µM 6.64883433954228 4.78394864119024e-14 yes 11 1.47711634726427e-11 5 2956062 YPR165W RHO1 SGTC_916 4466-0038 42 nM 6.28725105914987 9.52449528972573e-13 yes 12 1.61568290837609e-10 26 5722064 YGL116W CDC20 SGTC_63 0099-0242 26.702 µM 5.29365645415797 1.54156489139928e-09 yes 13 5.99472871665176e-08 47 3898502 YLR359W ADE13 SGTC_1061 3448-9325 110 µM 4.89578487977691 2.11514903394294e-08 yes 14 4.89570660468331e-07 11 723482 SGTC_138 0850-0259 40.9225 µM 4.86844698896719 2.51421278457928e-08 yes 15 5.62393429209275e-07 148 6813004 SGTC_1447 4239-0816 81.9 µM 4.77383001376488 4.54076478875379e-08 yes 16 9.03774827632308e-07 17 1341554 SGTC_2289 7946404 165.07 µM 4.62474526214886 1.1272409980138e-07 yes 17 1.8752952721095e-06 71 1246120 YPR165W RHO1 SGTC_1614 st002383 48.6 µM 4.48792758337448 2.53548351683661e-07 yes 18 3.59596826768603e-06 11 1947235 SGTC_1874 staurosporine 7.6 µM 4.04930195945411 2.92476224813792e-06 yes 19 2.56853139479416e-05 24 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2286 7945697 125 µM 3.78168477524475 1.1598396661057e-05 yes 20 7.78852678491894e-05 63 1245733 SGTC_315 k915-0449 187 µM 3.68295268099617 1.88655129585811e-05 yes 21 0.000115273983617048 63 20970215 YNL149C PGA2 SGTC_2584 androsterone 48.74 µM 3.63697980533896 2.35671501665893e-05 yes 22 0.000137926774645102 147 2754130 A steroid. SGTC_399 oxolinic acid 75 µM 3.60938938589941 2.6901416810697e-05 yes 23 0.000153459306336691 14 4628 A DNA gyrase inhibitor. SGTC_1455 4262-0120 131 µM 3.48305599555397 4.87363627587438e-05 yes 24 0.000247862332726231 38 1529587 SGTC_2239 6685329 187.64 µM 3.47443180349617 5.07187186315229e-05 yes 25 0.000255968238262624 45 805680 SGTC_1754 st042065 16.137 µM 3.45315327955684 5.59403043212885e-05 yes 26 0.00027703703518175 225 1126236 YIL048W NEO1 SGTC_531 3788-1495 174 µM 3.39489984369766 7.2950437987342e-05 yes 27 0.000343268553130366 37 2896655 SGTC_1531 st059297 52.4 µM 3.38767994826388 7.53695449780338e-05 yes 28 0.000352432311928152 37 7566702 SGTC_1339 1486-1321 22.7 µM 3.33666385905487 9.47409325276528e-05 yes 29 0.00042395215015615 48 3469382 SGTC_207 4185-0010 4.486 µM 3.28418541549859 0.000119487062760413 yes 30 0.000511388049508212 127 3761753 SGTC_122 0236-0016 402.397 µM 3.27780534078081 0.000122878666245215 yes 31 0.000523087569099789 68 6808838 SGTC_1800 st050079 29.0735 µM 3.24914304949829 0.000139259733303101 yes 32 0.000578766259525451 193 3645560 SGTC_1982 st072467 71.9 µM 3.21238734143445 0.000163267654670215 yes 33 0.000658183825475772 72 3163533 SGTC_3266 9136860 49.47 µM 3.12456578254878 0.000237202879839938 yes 34 0.000890338507011939 79 4871271 YPR165W RHO1 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 3.10980559023392 0.000252344697300538 yes 35 0.000936052590306957 73 6710655 SGTC_2635 hydroquinidine 100 µM 3.10787269486483 0.000254392993413701 yes 36 0.000942196103485918 46 442912 An experimental heart treatment. SGTC_40 0327-0103 19.753 µM 3.09555388566883 0.000267815792333984 yes 37 0.000982228373655257 65 409036 SGTC_649 1123-0311 367 µM 3.07128501075541 0.000296211156441345 yes 38 0.00106569796794099 122 693629 YIL048W NEO1 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 3.06223872608924 0.000307494621307747 yes 39 0.00109844084242717 42 803109 SGTC_1238 0333-0287 48.8 µM 3.03696235491069 0.000341177337461571 yes 40 0.00119487649439169 68 7226 SGTC_353 1988-1175 58.3 µM 2.97668716344282 0.000435818404959207 yes 41 0.0014569058359188 66 2788357 SGTC_2938 9059746 27.26 µM 2.96461173383051 0.000457490988291863 yes 42 0.00151532581797463 86 6471769 SGTC_3087 9117406 49.47 µM 2.86034361092933 0.000690670816676515 yes 43 0.00211591107916619 63 42546093 SGTC_609 0986-0026 86.3 µM 2.83985989009744 0.000747757840732308 yes 44 0.00225666762049393 95 2848610 SGTC_551 k048-0028 34.9 µM 2.81563010233993 0.000820884160665814 yes 45 0.00243408406556039 73 6836383 SGTC_2053 5265679 138 µM 2.76031985813441 0.00101311564297205 no 46 0.00288723971450889 102 764595 SGTC_406 estrone 100 µM 2.75492007289059 0.00103394261796726 no 47 0.0029353237401916 61 5870 A steroid. SGTC_1465 k213-0056 144 µM 2.74233140681284 0.00108403106573862 no 48 0.00305023787442492 80 24048857 YMR208W ERG12 SGTC_1333 1482-0047 286 µM 2.68683328761942 0.00133246772478075 no 49 0.00360664724917802 92 3811116 SGTC_1030 k029-0042 36.7 µM 2.63584062506349 0.00160552914458965 no 50 0.0041964570680755 127 6080581 SGTC_2674 ligustilide 100 µM 2.62144704616281 0.00169134609993035 no 51 0.00437786817228685 61 5319022 A signalling regulator. SGTC_986 1493-0483 84 µM 2.60160152941928 0.00181652135806163 no 52 0.00463947973594543 82 40079 SGTC_178 4092-0806 87.505 µM 2.59934022553588 0.00183130667648347 no 53 0.00467015741022002 218 2169044 SGTC_1049 3226-0134 66 µM 2.58887519363285 0.00190116650319636 no 54 0.00481449932450067 138 5702385 SGTC_187 1488-2104 32.728 µM 2.58614244706091 0.00191980353073965 no 55 0.00485284051330295 110 2852859 SGTC_768 0384-0033 77.3 µM 2.5566878097634 0.00213148023782261 no 56 0.00528370045766855 194 3965305 YMR134W ERG29 SGTC_920 mycophenolic acid 780.421 nM 2.50876315589037 0.00252147050203633 no 57 0.00605773437114326 138 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 2.50841595616786 0.00252451717694827 no 58 0.00606369067956368 114 16623 A steroid. SGTC_1814 st052110 31.539 µM 2.50592038897591 0.00254651387126767 no 59 0.00610665577403103 81 674163 SGTC_1264 0783-0040 158 µM 2.49916444497206 0.00260693484064828 no 60 0.00622432649111159 125 2855798 SGTC_2934 9036370 36.88 µM 2.48613484311207 0.002727134089032 no 61 0.00645695116984926 142 6462800 SGTC_410 α-linolenic acid 100 µM 2.482584050054 0.00276074665902322 no 62 0.00652166464869044 118 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_1394 3474-0001 65.7 µM 2.43061670985369 0.0032973284947268 no 63 0.00753657532477212 125 5017666 YIL048W NEO1 SGTC_2147 5545932 89.7195 µM 2.42368988121367 0.00337552449852175 no 64 0.0076818595568242 96 797404 SGTC_3214 9129694 49.47 µM 2.41888753741107 0.0034307116613579 no 65 0.00778402627822949 138 17158655 SGTC_1239 0337-0584 35.4 µM 2.41758225778347 0.00344585101650647 no 66 0.00781200108569474 193 914301 YML130C ERO1 SGTC_1328 1441-0025 69.2 µM 2.41187386125642 0.00351276776350909 no 67 0.00793538560719045 90 4562601 SGTC_1482 3346-2049 8.48 µM 2.37913650250334 0.00391956136752819 no 68 0.00867662428781516 138 3826804 SGTC_1649 st011737 51.3 µM 2.37516153782555 0.00397172365971743 no 69 0.0087706357711159 103 1761035 SGTC_1184 1269-1718 139 µM 2.35646471464466 0.00422550981563074 no 70 0.00922491018622048 126 5403821 SGTC_2389 9091542 195.52 µM 2.34719569676115 0.00435662374213623 no 71 0.00945765851505779 151 3626624 YOL127W RPL25 SGTC_460 trequinsin 123 µM 2.31868756675009 0.00478296646345811 no 72 0.0102059915828042 80 5537 A vasodilator. SGTC_1047 2043-3044 82 µM 2.28651978285305 0.00530838309048055 no 73 0.0111119340657004 179 669592 SGTC_2587 piperic acid 92.2 µM 2.28505336105893 0.005333513848959 no 74 0.0111548495318734 158 5370536 SGTC_2919 7978188 46.38 µM 2.26563467210984 0.00567641817557453 no 75 0.011736880192855 150 2980291 SGTC_1837 st055472 66.5 µM 2.25969832930824 0.00578508147810246 no 76 0.0119199900347846 153 676091 SGTC_1340 1486-1359 257 µM 2.25925425460622 0.005793283877568 no 77 0.0119337868493873 155 4309068 SGTC_304 1310-0298 97 µM 2.25183633629782 0.00593183265167027 no 78 0.0121663082563389 229 1550234 SGTC_3350 9150499 3.57 µM 2.25139639492017 0.00594014123317915 no 79 0.0121802211339223 215 4910996 YPR165W RHO1 SGTC_1578 josamycin 24.2 µM 2.23664913456948 0.00622469073296801 no 80 0.0126546404469131 144 5282165 A P450 substrate. SGTC_1719 st032227 49.2 µM 2.23274728779421 0.00630196853862471 no 81 0.0127828070757269 165 3125804 SGTC_1408 3909-7976 48.8 µM 2.21608947152123 0.00664151951350809 no 82 0.0133426875819525 181 24152374 SGTC_917 harmaline 728.087 nM 2.19971920812174 0.00699086479722513 no 83 0.0139134115682149 180 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_1043 0916-0009 19.3 µM 2.18316348831447 0.00736056663735605 no 84 0.0145118862543869 206 3101130 SGTC_2619 obliquin 87.91 µM 2.17717425162209 0.0074984952308595 no 85 0.0147337843345705 342 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2314 7727897 200 µM 2.17323464238294 0.00759045881445007 no 86 0.0148813308531534 154 900724 SGTC_2229 7354935 190 µM 2.16358208538657 0.00781999140780553 no 87 0.0152482188277347 107 318112 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 2.15985228344722 0.00791030664461123 no 88 0.0153920533395187 188 5355888 SGTC_1280 0880-0253 10.1 µM 2.1438892475908 0.00830728910875476 no 89 0.0160208809731668 186 6836607 SGTC_1996 st072960 66.8 µM 2.14345112971864 0.00831842696909633 no 90 0.016038445626431 172 1719405 SGTC_1801 st050089 28.441 µM 2.14308682247914 0.00832769839393074 no 91 0.016053063691698 314 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1789 tunicamycin 25 nM 2.12969610499371 0.00867484143344678 no 92 0.0165983553874977 201 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_536 3852-0578 10.6 µM 2.11869042452009 0.00896959067983366 no 93 0.0170583190557902 170 2869208 SGTC_2920 7982904 15.77 µM 2.11260439750982 0.00913632190128118 no 94 0.0173173210123582 182 6456808 SGTC_2640 pentamidine 10.38 µM 2.09234712330782 0.00971098784642273 no 95 0.0182037375863147 224 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2041 5107442 45.335 µM 2.08821079790931 0.00983213655499932 no 96 0.0183894118540749 229 793005 SGTC_2245 6637752 200 µM 2.08209899749344 0.0100135606165785 no 97 0.018666714052238 128 681890 SGTC_1900 st060200 72.8 µM 2.08203498339346 0.0100154761853102 no 98 0.0186696372067994 176 688945 SGTC_2259 7964009 200 µM 2.06130263167898 0.0106529484294538 no 99 0.0196370886537266 194 313134 SGTC_2965 9082772 38.63 µM 2.06008160469629 0.0106915702811337 no 100 0.0196953700674343 231 16459634 SGTC_1962 st076595 64.5 µM 2.05882125540941 0.0107315637549181 no 101 0.0197556823490547 211 279619 SGTC_2054 5233173 129 µM 2.03224939184022 0.0116055915822678 no 102 0.0210642074868921 285 6889 SGTC_1895 st058434 18.3 µM 2.03049521990428 0.0116654068955051 no 103 0.0211531132829855 204 5393175 SGTC_3324 9138759 60.749 µM 2.01960723512921 0.012042694236973 no 104 0.0217120720409571 198 45595710 SGTC_448 monastrol 171 µM 2.01156878500394 0.0123279874149194 no 105 0.0221327063250547 189 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_43 0570-0105 72.5 µM 2.0001151791341 0.0127445943015955 no 106 0.0227439140316226 386 1114046 YDL195W SEC31 SGTC_984 1492-0255 2.91 µM 1.99717101850864 0.0128536314628072 no 107 0.0229033041016936 207 1585198 SGTC_825 1988-2224 89.6 µM 1.99349710031654 0.0129908261228771 no 108 0.023103520372834 252 1180859 SGTC_1051 3253-3903 78 µM 1.98833942824296 0.0131855636796805 no 109 0.023387081464954 252 5509239 SGTC_1292 0kpi-0043 232 µM 1.976298226237 0.0136500450220309 no 110 0.0240605051960837 207 3333905 SGTC_1157 4092-0394 27.6 µM 1.97531598551112 0.013688549640965 no 111 0.0241161501356518 258 3659885 SGTC_2181 6316240 54.2555 µM 1.95822622715856 0.0143736341991813 no 112 0.0251017364561846 215 12779990 SGTC_7 0192-1582 4.227 µM 1.94716087450115 0.0148327932026545 no 113 0.025757725370324 324 252616 SGTC_3164 9100705 49.47 µM 1.94244138256368 0.0150324339999953 no 114 0.026041844825503 169 17174235 SGTC_1334 1486-0610 236 µM 1.93166427931473 0.0154969951321122 no 115 0.0267004782000822 247 3742339 SGTC_765 1319-0117 244 µM 1.93123744584458 0.0155156452888803 no 116 0.0267268475990483 225 3487746 YGL099W LSG1 SGTC_2572 astragaloside iv 100 µM 1.92932040420639 0.015599646681921 no 117 0.0268455491043765 250 45006101 An anti-inflammatory agent. SGTC_2669 eugenol 100 µM 1.92883907513383 0.0156207988661338 no 118 0.0268754216051544 162 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2092 5303694 80.6725 µM 1.92012936441095 0.0160078234215818 no 119 0.0274207805070653 272 1963699 SGTC_760 0568-0725 82.9 µM 1.91882364401857 0.0160665470790696 no 120 0.0275033282497057 207 3916171 SGTC_1230 0170-0365 3.77 µM 1.91348938095709 0.0163083725994542 no 121 0.0278427158322075 387 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_714 4296-0578 26.1 µM 1.89973997620102 0.0169461112038575 no 122 0.0287336257045533 125 1589775 SGTC_1769 st044406 64.4 µM 1.89913976006737 0.0169744301046729 no 123 0.028773051306967 264 670903 SGTC_1066 ketoconazole 628 nM 1.89345580590751 0.0172446172382852 no 124 0.0291486400381934 279 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_3100 9120536 49.47 µM 1.88773996448303 0.0175200167614458 no 125 0.029530434186944 163 16421196 SGTC_441 propafenone 146 µM 1.88578568875081 0.0176150346485153 no 126 0.029661920113898 190 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_1499 4480-0877 67.3 µM 1.88241633559228 0.017779887224654 no 127 0.0298897548272745 181 2861909 SGTC_1379 2144-0755 36.5 µM 1.882007850709 0.0177999623670109 no 128 0.0299174748560072 277 5392327 SGTC_2182 6325192 200 µM 1.87598057111372 0.0180984301821082 no 129 0.0303289739086266 215 736248 SGTC_2860 9025725 38.96 µM 1.87144080334188 0.0183260444272582 no 130 0.0306420038644023 219 40546248 SGTC_3345 9148410 3.559 µM 1.86816862105242 0.0184916130560394 no 131 0.0308692855508493 200 4903596 SGTC_2085 5307070 144.047 µM 1.85852277160917 0.0189871123247715 no 132 0.0315474063558923 230 2840351 SGTC_2300 7976697 71.57 µM 1.85450230189382 0.0191969503520065 no 133 0.0318336655674503 237 2236109 SGTC_213 1246-0773 967 nM 1.85013941617863 0.0194268869310052 no 134 0.0321467290818032 283 6251622 SGTC_1263 0774-1208 64.8 µM 1.8418861825252 0.0198682586956795 no 135 0.0327459000818331 342 906585 SGTC_2834 9001755 58.44 µM 1.8394455959709 0.0200003971323721 no 136 0.032924836454387 258 2989575 SGTC_1424 4048-1941 275 µM 1.83866166631812 0.0200429985972619 no 137 0.0329824825020212 291 X1424 SGTC_1694 st024011 44.9 µM 1.8358872099202 0.0201943910050002 no 138 0.0331871698457955 293 2787533 SGTC_2997 9067075 71.4286 µM 1.8337982341259 0.0203090180153038 no 139 0.0333419749856966 312 27209819 SGTC_2219 9098279 200 µM 1.83195261951158 0.0204107496722539 no 140 0.033479239971669 245 902349 SGTC_556 4058-0063 51.5 µM 1.82286895662217 0.0209177632097509 no 141 0.0341616203267568 288 6615692 SGTC_2687 chenodiol 100 µM 1.81189814733756 0.021544283742202 no 142 0.0350009678660513 256 5702181 A cholesterol synthesis inhibitor. SGTC_582 0987-0078 156 µM 1.80853117906384 0.0217397165934229 no 143 0.035261934347433 411 1625765 SGTC_2347 9049783 174.81 µM 1.80457867569055 0.0219710451974293 no 144 0.0355703187330113 336 6467988 YPL169C MEX67 SGTC_3024 9090631 49.47 µM 1.79527883228538 0.0225235471905187 no 145 0.0363046429319843 224 25236383 SGTC_1135 dihydrocapsaicin 536.708 nM 1.79382691286338 0.0226108539241823 no 146 0.0364203999538224 312 107982 A Capsaicinoid. SGTC_1803 st050068 52.4 µM 1.78447526884073 0.023180049156743 no 147 0.0371732349779502 546 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_703 3875-0075 71.8 µM 1.7776200797124 0.0236049172980096 no 148 0.0377331368234019 241 2850814 SGTC_1602 st001878 87.6 µM 1.77403698512656 0.0238295830120548 no 149 0.0380285164048513 267 595405 YLR310C CDC25 SGTC_3321 9137793 26.8275 µM 1.77032167964804 0.0240644340538353 no 150 0.0383367842669221 342 4904192 SGTC_893 0958-0369 48.9 µM 1.76869000737273 0.0241681878317685 no 151 0.0384728103890497 335 6819948 SGTC_3242 9133940 49.47 µM 1.75795282658331 0.0248603492548122 no 152 0.0393777681109648 262 17248444 SGTC_2890 9046729 58.44 µM 1.75684780264738 0.0249325177563989 no 153 0.039471877320865 264 903329 SGTC_3197 9113331 49.47 µM 1.75573239405984 0.0250055425443133 no 154 0.0395670564021319 329 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_863 0466-0191 129 µM 1.74502769873764 0.0257155305081578 no 155 0.0404900237950727 359 765160 YPR165W RHO1 SGTC_303 1348-1668 34.2 µM 1.74330031658531 0.0258316652347364 no 156 0.0406405850502565 266 5380509 SGTC_1147 3809-1045 12.3 µM 1.74107127114709 0.0259821758922901 no 157 0.0408355432033791 311 325925 SGTC_113 0099-0221 2.5 µM 1.73670471830284 0.0262791428598245 no 158 0.0412196522544467 293 89219 SGTC_1707 st032323 6.317 µM 1.7281309678566 0.0268704976349822 no 159 0.04198237328741 351 3132057 YMR211W DML1 SGTC_216 k038-0035 28.382 µM 1.72556937441042 0.0270493184165616 no 160 0.0422124564996113 283 4444231 YPR107C YTH1 SGTC_1884 5633444 25 µM 1.70842648052863 0.0282717679183989 no 161 0.0437786186175032 373 5724239 SGTC_510 ag-490 170 µM 1.70692635352225 0.028380895131711 no 162 0.0439178709081082 272 5328779 SGTC_2549 cedrol 20.94 µM 1.70303108712211 0.0286658952197184 no 163 0.0442811254498327 256 6708665 A sedative which affects the nervous system. SGTC_1899 st063254 59.6 µM 1.70139873863266 0.0287860328834065 no 164 0.0444340690031237 274 3093813 SGTC_117 lucigenin 22.078 µM 1.69206987656964 0.0294806772260601 no 165 0.0453163256051375 413 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_664 1222-0054 14.9 µM 1.68897464878207 0.0297142059295458 no 166 0.0456121441461165 342 6813991 SGTC_3066 9117245 49.47 µM 1.67741786444623 0.0305997466340203 no 167 0.046730399221357 321 17176980 SGTC_1891 st059073 26.2 µM 1.67335994183452 0.0309158246757028 no 168 0.047128229376298 359 688754 SGTC_2162 5663267 200 µM 1.67135086436399 0.0310733122332239 no 169 0.0473261975735101 306 6456493 SGTC_2322 7413319 38.22 µM 1.66732454066318 0.031390925972633 no 170 0.0477249447195009 520 1840400 SGTC_601 0986-0029 62.9 µM 1.66097757072342 0.0318970496976209 no 171 0.0483589757338697 391 24747981 SGTC_1349 flufenamic acid 69 µM 1.65827992726239 0.0321141985345243 no 172 0.0486304892944975 317 3371 A non-steroidal anti-inflammatory. SGTC_883 0850-0245 24.6 µM 1.65655748506392 0.0322534851619692 no 173 0.0488044869360008 379 6823229 YPR165W RHO1 SGTC_957 1187-1561 14.1 µM 1.6532015176539 0.0325263002615373 no 174 0.0491449288624355 373 1538454 SGTC_2790 5423970 71.43 µM 1.65118429156884 0.0326911996808027 no 175 0.0493504748277639 408 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2163 5671233 125 µM 1.64655187083758 0.0330724900577278 no 176 0.0498250950136781 374 701023 SGTC_943 3253-1379 105 µM 1.64623478420877 0.0330987226097977 no 177 0.0498577151896923 344 668464 SGTC_3344 9148862 3.898 µM 1.63772094024369 0.0338095064432413 no 178 0.0507399601574699 339 4905352 SGTC_2752 diclazuril 33.15 µM 1.63013497366495 0.0344533604173747 no 179 0.0515364867398211 524 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_3073 9114972 49.47 µM 1.62043785971811 0.0352910314568707 no 180 0.0525691263375702 320 41905075 SGTC_1773 st048542 73.5835 µM 1.62021043028233 0.035310876351152 no 181 0.0525935408156618 391 3237138 SGTC_1942 st076330 65.2 µM 1.61786688750036 0.0355159012954838 no 182 0.0528456438375803 341 24208414 SGTC_1624 st003710 6.25 µM 1.6165333740666 0.0356329987979795 no 183 0.0529895218597886 424 24207033 SGTC_1320 1313-0481 95.3 µM 1.61567043432733 0.0357089431428417 no 184 0.0530827932759458 351 6813365 YLR208W SEC13 SGTC_3260 9137109 49.47 µM 1.61376533565168 0.0358770740318773 no 185 0.053289168062973 256 17478346 SGTC_1194 1488-0194 225 µM 1.61168397002433 0.0360615017969208 no 186 0.0535153638326225 411 1391452 SGTC_262 fenpropimorph 62.5 µM 1.61141593303327 0.0360853086239258 no 187 0.053544548393891 329 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2757 clomiphene 4.22 µM 1.60334507840442 0.0368082050298167 no 188 0.0544292446543478 423 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_721 1187-1332 279 µM 1.59780004373619 0.0373116971503507 no 189 0.0550437424599814 255 25730 SGTC_1505 k297-0037 20.6 µM 1.59731354951007 0.03735613826619 no 190 0.0550979160031708 382 4089396 SGTC_1055 3448-0672 86 µM 1.59382989149693 0.0376756342999172 no 191 0.0554870702804684 374 748378 SGTC_1365 1672-3266 55.4 µM 1.59095840495837 0.037940660429617 no 192 0.0558094685248328 397 6415873 SGTC_3215 9129942 49.47 µM 1.58828897520026 0.0381884000057359 no 193 0.0561105046687381 322 17682944 SGTC_855 0428-0020 25 µM 1.58650550192145 0.0383546512937233 no 194 0.0563123425271536 326 6812414 SGTC_335 4077-0256 27.6 µM 1.57829669964212 0.0391274808999826 no 195 0.057248731888057 425 3121989 SGTC_1146 3579-1023 7 µM 1.57502724481528 0.0394387973157604 no 196 0.0576250779778524 434 X1146 SGTC_1281 0884-0031 11.8 µM 1.5745280764539 0.0394865047954401 no 197 0.0576827079382545 415 1548255 SGTC_2413 inermin 26.06 µM 1.5739705956 0.0395398409076826 no 198 0.0577471237521215 429 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_719 2810-4230 27.3 µM 1.57335399845851 0.0395989011104459 no 199 0.0578184361971783 318 721079 SGTC_1952 st077036 64.1 µM 1.56924971412186 0.0399938567730405 no 200 0.0582948822033649 409 2937007 SGTC_1370 2001-0092 44.6 µM 1.5690064748908 0.0400173638295275 no 201 0.0583232151531548 458 790957 SGTC_677 0929-0063 136 µM 1.56897186555289 0.0400207094475213 no 202 0.0583272473908702 309 1539583 SGTC_3308 9128332 17.569 µM 1.56806887712938 0.0401080799546864 no 203 0.0584325294653783 488 17332805 YDL196W YDL196W SGTC_2763 lisinopril 49.32 µM 1.56360522144652 0.0405422491878599 no 204 0.0589551539527105 336 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_833 3852-0053 558 µM 1.56278631490405 0.0406223149707409 no 205 0.0590514320613072 422 3123681 SGTC_3033 9090887 49.47 µM 1.56185915657381 0.0407131195579939 no 206 0.0591605860584109 425 19325384 SGTC_3226 9131256 49.47 µM 1.56159823942018 0.0407387030968543 no 207 0.0591913322503043 226 17178073 SGTC_1029 k015-0030 64.7 µM 1.55535502620303 0.0413547651267544 no 208 0.0599307694436534 387 2208316 SGTC_2153 5569715 200 µM 1.55294107507725 0.0415949818453787 no 209 0.0602186063102113 358 2054701 SGTC_65 0798-0905 34.986 µM 1.54613839924495 0.0422780147897079 no 210 0.0610355733804177 524 3602145 SGTC_1414 3917-0015 5.4 µM 1.54276945746389 0.0426196229237428 no 211 0.0614433612517556 352 6618702 SGTC_1634 st006576 41 µM 1.53867710805046 0.0430375823362588 no 212 0.0619415718228955 391 3915356 SGTC_2152 5568786 200 µM 1.5382956182968 0.0430767127597898 no 213 0.0619881753078407 398 5399883 SGTC_1383 3049-0032 20.7 µM 1.53783386463058 0.0431241145095453 no 214 0.0620446205759913 416 712864 SGTC_2981 9013952 38.96 µM 1.53601020218028 0.043311736215984 no 215 0.0622679390931717 392 2996344 SGTC_1748 st037455 53.6035 µM 1.53526983625263 0.0433880942790741 no 216 0.0623587801112277 422 580690 SGTC_1818 st052136 56.3 µM 1.53017023771342 0.043917001219318 no 217 0.0629872981134148 428 674169 SGTC_2102 5377816 72.7585 µM 1.5205002068483 0.0449342055270408 no 218 0.0641926533996296 422 1379702 SGTC_1650 st011916 45.8 µM 1.51623331225186 0.0453890364616316 no 219 0.0647301837529489 359 242528 SGTC_2319 6033012 152.6 µM 1.51590764040122 0.0454239031034411 no 220 0.0647713540441633 343 847246 SGTC_2612 dictamnine 15.46 µM 1.51580150885961 0.0454352702684393 no 221 0.0647847752127404 418 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_905 2-aminofluorene 215 µM 1.51359471730239 0.0456721463087494 no 222 0.0650643308962341 450 1539 An established DNA mutagen. YPR165W RHO1 SGTC_486 niguldipine 82 µM 1.51205860607213 0.0458376170793866 no 223 0.065259477026902 349 1236 A calcium channel blocker. SGTC_2517 totarol 10 µM 1.50909713505869 0.0461579879709379 no 224 0.0656369808030092 379 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2804 7954240 19.48 µM 1.50660663567717 0.0464287992352133 no 225 0.0659557577606932 454 828705 SGTC_2561 acetosyringone 100 µM 1.5059286302592 0.0465027444640914 no 226 0.0660427479789975 479 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_875 0709-0210 25.7 µM 1.50452412769313 0.0466562242791703 no 227 0.0662232328249712 459 6251364 SGTC_787 4152-0075 138 µM 1.49547057413297 0.0476553476415007 no 228 0.0673958369796732 421 9566539 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.4888067776173 0.0484016357457463 no 229 0.0682691285359187 359 6857784 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.48097224094266 0.0492909594289034 no 230 0.0693069853795347 395 2374 Ca(2+)-ATPase inhibitor. SGTC_102 gallobenzophenone 83.616 µM 1.47766571814616 0.0496701874730089 no 231 0.0697486373117076 461 70837 SGTC_2841 9004761 38.96 µM 1.46936760090717 0.0506321622747442 no 232 0.0708665550634083 400 2991039 SGTC_762 1165-0429 115 µM 1.46529776979701 0.0511093587954088 no 233 0.0714198473666287 436 5967793 SGTC_802 4112-3352 742 µM 1.46267332880479 0.051418973641113 no 234 0.0717783937909302 491 704594 SGTC_942 3253-1115 227 µM 1.46258157767704 0.0514298247836467 no 235 0.0717909535968933 436 46497897 SGTC_640 3381-0960 37.1 µM 1.46235643953462 0.0514564589431498 no 236 0.0718217798853965 453 1745025 SGTC_509 pifithrin 175 µM 1.46094775213025 0.0516233577807566 no 237 0.0720148902315107 393 4817 A p53 inhibitor. SGTC_2713 st079149 53.4 µM 1.46034647821012 0.0516947266007515 no 238 0.0720974371706629 464 3103253 SGTC_461 N-acetylfarnesylcysteine 136 µM 1.45864446916191 0.0518971736016227 no 239 0.0723314937105668 362 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_585 0kpi-0023 191 µM 1.45769534559723 0.0520103412851268 no 240 0.0724622677265796 399 64601 SGTC_2798 7813637 45.45 µM 1.45662381885146 0.0521383390963842 no 241 0.0726101245316585 456 956368 SGTC_68 0986-0284 82.829 µM 1.45486883805012 0.0523485183622502 no 242 0.0728527881312638 432 423278 YIL048W NEO1 SGTC_2416 tofa 880 nM 1.45315943469201 0.0525538854031184 no 243 0.0730897460869639 434 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_3014 9081533 49.47 µM 1.4499326108618 0.0529432971805593 no 244 0.0735386561744338 446 21367265 SGTC_1218 1348-1416 30.7 µM 1.44769898976011 0.0532141874582979 no 245 0.0738506263036599 462 6787668 SGTC_2419 paclitaxel 166.5 µM 1.44064602377746 0.054076778564973 no 246 0.0748423555336612 534 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2227 7312221 64.1025 µM 1.43764058080818 0.0544476964109994 no 247 0.0752680302144917 393 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 1.43752757152078 0.0544616826522666 no 248 0.0752840721695917 521 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3160 9100216 49.47 µM 1.43624829477946 0.0546202065688093 no 249 0.0754658505444604 454 17191039 SGTC_2768 sulfasalazine 50.2 µM 1.4307558521234 0.0553049624675467 no 250 0.0762500999266443 448 5384001 An antioxidant and salicylic acid derivative. SGTC_111 0083-0039 52.457 µM 1.42625413451608 0.0558712427573876 no 251 0.0768974993048027 292 759313 SGTC_499 genistein 192 µM 1.42263200030939 0.056330191322789 no 252 0.0774214311943735 387 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_3323 9138564 53.9225 µM 1.41686695914667 0.0570667836698966 no 253 0.0782609141333975 518 43912313 YNL103W MET4 SGTC_1980 st071811 45.7 µM 1.41535149541228 0.0572616658731575 no 254 0.0784827317855449 454 4974850 SGTC_3042 9091578 49.47 µM 1.41133766241143 0.0577803587379904 no 255 0.0790725371615949 405 25236497 SGTC_3216 9129716 49.47 µM 1.40855395074273 0.0581422517914126 no 256 0.07948355172414 442 8056934 SGTC_1196 1588-0294 184 µM 1.40627727996863 0.0584395494904807 no 257 0.0798209020015813 439 6144269 SGTC_2321 7390090 138.78 µM 1.40455949017988 0.0586646552045077 no 258 0.080076154923709 423 649046 SGTC_3261 9137475 49.47 µM 1.40119930635356 0.059106953905071 no 259 0.080577240842442 268 17027690 SGTC_1112 tnp00069 1.16933 µM 1.39760883099062 0.0595824518933268 no 260 0.0811152825032684 538 145826 SGTC_1622 st003707 19.4 µM 1.38571504444045 0.0611790203401607 no 261 0.0829169662430833 524 10140899 SGTC_560 2332-1943 155 µM 1.38505634344779 0.0612684091120531 no 262 0.0830176197934223 474 21177716 SGTC_592 k241-0073 46.5 µM 1.37911593030343 0.0620791673279278 no 263 0.0839295064689278 510 4230158 SGTC_1467 k284-1082 293 µM 1.37681066119235 0.0623960398242845 no 264 0.0842853969133933 513 3334705 SGTC_339 3091-4833 71.4 µM 1.37639526342474 0.0624532725120404 no 265 0.084349646812449 475 3240077 SGTC_638 3970-0837 4.09 µM 1.37603476732213 0.0625029741234156 no 266 0.0844054348091283 502 4118451 YLR208W SEC13 SGTC_1317 1273-0028 910 nM 1.3754666677124 0.0625813606200231 no 267 0.084493406338567 491 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2427 5545055 42.75 µM 1.36748225519672 0.0636911761115374 no 268 0.0857370977637793 541 5372858 SGTC_200 k038-0079 37.545 µM 1.35629193217313 0.0652723001337959 no 269 0.0875031507187393 489 3436683 SGTC_484 loperamide 105 µM 1.35583860300818 0.065336988844751 no 270 0.0875752629349394 387 3955 An opioid-receptor agonist. SGTC_546 peri-Naphthalide 147 µM 1.35056134705024 0.0660937014373943 no 271 0.0884179948392695 515 223824 A penicillin ester. SGTC_2808 7946468 45.46 µM 1.34939340390674 0.0662620883399307 no 272 0.0886053191768584 573 2970879 SGTC_2458 5808907 16.39 µM 1.34868613878635 0.0663642189020144 no 273 0.0887188997999808 525 2731747 SGTC_2251 lansoprazole 556 µM 1.34777719040782 0.0664956518813681 no 274 0.0888650281707878 394 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1735 st034310 56.75 µM 1.34712730494291 0.066589748116208 no 275 0.0889696177415549 519 871153 SGTC_89 0302-0250 142.109 µM 1.34438498812845 0.0669879406781113 no 276 0.0894119628265713 557 4203518 YLR208W SEC13 SGTC_1391 3442-0225 151 µM 1.34358858933983 0.0671039245713125 no 277 0.0895407306925865 451 5227075 SGTC_1941 st076221 61.8 µM 1.34344811062483 0.0671243993544888 no 278 0.0895634586704758 581 2828568 SGTC_2670 beta-carotene 100 µM 1.34216548064771 0.0673115662530725 no 279 0.0897711731402656 422 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_1530 rhein 70.4 µM 1.34066748314588 0.06753067096001 no 280 0.0900142182223213 546 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2468 5987765 72.9 µM 1.34058399566767 0.0675428984563179 no 281 0.0900277781566493 520 26772094 SGTC_1092 toremifene 6.32 µM 1.33884478237371 0.0677980111956311 no 282 0.0903106043086391 569 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_447 ml7 120 µM 1.33884143834471 0.0677985024231536 no 283 0.090311148740436 513 4216 Selective myosin light chain kinase inhibitor. SGTC_1752 st044819 83.042 µM 1.33735437912886 0.0680172193685828 no 284 0.0905534942179093 512 441209 YML126C ERG13 SGTC_2016 5121758 140 µM 1.33726269776974 0.0680307216875532 no 285 0.0905684512786854 577 2795203 SGTC_898 1000-0849 28.3 µM 1.33692607705518 0.0680803150564535 no 286 0.0906233839122672 521 6751807 SGTC_51 1013-0126 23.419 µM 1.33365836992369 0.0685631885576261 no 287 0.0911579220013236 492 1627850 SGTC_2877 9040724 71.43 µM 1.33185007037134 0.0688315365336376 no 288 0.09145473042001 509 6463895 SGTC_527 4476-4215 268 µM 1.32973860673472 0.0691458973721361 no 289 0.0918022049880722 534 4418754 SGTC_1490 4089-0339 670 nM 1.32898265758623 0.0692587138259298 no 290 0.091926845756828 487 742542 SGTC_1433 4060-0023 7.6 µM 1.32844194433073 0.0693394958252347 no 291 0.0920160753189224 543 3840627 SGTC_2715 st079500 56.4 µM 1.32678061445406 0.0695881508897066 no 292 0.0922906324565789 480 28246688 SGTC_886 0866-0150 153 µM 1.32511136534815 0.0698386821515341 no 293 0.0925671085450355 551 271463 SGTC_3304 9125678 46.087 µM 1.31857263687126 0.0708267445296747 no 294 0.0936560133054624 556 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_1896 st058441 89 µM 1.31794438866478 0.0709222413354862 no 295 0.0937611324111665 495 688759 SGTC_2482 5981709 142.65 µM 1.3154466714527 0.0713028851062358 no 296 0.0941799144440366 578 877755 SGTC_846 0335-0850 148 µM 1.31522582470019 0.0713366167324575 no 297 0.0942170092062328 488 6819598 SGTC_1596 piperlongumine 63 µM 1.3141853074724 0.0714957077761185 no 298 0.0943919258151403 580 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_131 0141-0277 33.849 µM 1.31046780163265 0.0720663246050774 no 299 0.0950188149076149 543 1547771 SGTC_3060 1327-0027 12.5 µM 1.30974821250528 0.0721771798144002 no 300 0.0951405138585482 494 16000455 YPR107C YTH1 SGTC_3250 9135583 49.47 µM 1.30679137002009 0.0726340640122539 no 301 0.095641788457497 510 7699353 SGTC_864 0469-0573 172 µM 1.30529474205263 0.0728661620499117 no 302 0.0958962518883137 530 689425 SGTC_2975 9084847 53.72 µM 1.30528903568565 0.0728670480822692 no 303 0.095897223062512 547 27211724 SGTC_320 4092-0846 5.34 µM 1.30309594119949 0.0732081827888068 no 304 0.0962710045679502 542 1359356 SGTC_1523 st012844 44.7 µM 1.30042763244089 0.0736248829769472 no 305 0.0967272221845184 553 4274103 SGTC_2449 5812982 45.77 µM 1.30036843997214 0.0736341473689321 no 306 0.0967373606662599 500 776185 SGTC_318 1488-0629 67.2 µM 1.29940507140097 0.0737850524114964 no 307 0.0969024760913777 507 3662576 SGTC_2184 6075246 200 µM 1.29695805901513 0.0741694227023063 no 308 0.0973228090159024 551 2267320 SGTC_865 0488-0499 301 µM 1.29630896140028 0.0742716374584832 no 309 0.0974345312080119 592 9634651 SGTC_1743 st037606 46.3785 µM 1.2939470303728 0.0746444837166687 no 310 0.0978418589632586 533 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2180 6301957 200 µM 1.29319916940539 0.0747628357216876 no 311 0.0979710914349124 526 845462 SGTC_3235 9132602 49.47 µM 1.28887251801229 0.0754503578198281 no 312 0.0987212048262021 590 4912240 SGTC_130 0136-0219 337.655 µM 1.28541771795177 0.0760027907097239 no 313 0.0993231764941283 573 234244 SGTC_2091 4-phenylthiadiazole 200 µM 1.28518777863952 0.0760396677129045 no 314 0.0993633366479341 567 270010 SGTC_2899 9053889 58.44 µM 1.28504925041641 0.0760618910440845 no 315 0.099387537086389 524 6470052 SGTC_1452 4194-0072 190 µM 1.28296811752885 0.0763963513041691 no 316 0.0997516230907703 618 1343545 SGTC_3055 9094636 49.47 µM 1.28241937938926 0.076484725523833 no 317 0.0998477847955667 523 25236176 SGTC_2428 5615643 7.78 µM 1.28137793384781 0.0766526640506999 no 318 0.100030475463548 536 2253075 SGTC_1573 oleylamine 1.06 µM 1.27917125239567 0.077009429371832 no 319 0.100418378398306 564 5356789 An amine of the fatty acid oleic acid. SGTC_3078 9116413 49.47 µM 1.27852044384338 0.0771148894949637 no 320 0.100532990528046 508 17177322 SGTC_278 4092-0821 23.9 µM 1.27726527634163 0.07731859270998 no 321 0.100754304136321 559 877900 SGTC_3297 9117502 71.43 µM 1.27659972414147 0.0774267719819809 no 322 0.10087179966107 534 7453720 SGTC_1473 k844-0725 134 µM 1.27621009018783 0.0774901566549686 no 323 0.100940631364552 644 54682906 SGTC_1456 k015-0012 13 µM 1.27492801979962 0.0776989988064336 no 324 0.101167360222164 638 2989616 SGTC_1073 triclabendazole 3.09 µM 1.27021519133268 0.0784703654897449 no 325 0.102003993909321 635 50248 An antihelmetic and likely tubulin inhibitor. SGTC_1044 1222-0021 1.78 µM 1.2695872361891 0.0785735820973242 no 326 0.102115849164052 567 4306703 SGTC_156 3474-0145 5.642 µM 1.26839781696353 0.078769368227341 no 327 0.102327960415447 567 2265471 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.26214219765768 0.0798051728074979 no 328 0.103448811730878 544 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_236 1509-0011 5.31 µM 1.26092098710192 0.0800085771562571 no 329 0.103668657978777 864 3107280 SGTC_364 0083-0097 67.7 µM 1.25905100539856 0.0803207998734485 no 330 0.104005954734124 578 5207356 SGTC_797 k781-0471 270 µM 1.25837284869144 0.0804342559612867 no 331 0.104128473230943 591 23738129 SGTC_2753 fluvastatin 17.09 µM 1.25670763127314 0.0807133616310886 no 332 0.104429761882902 584 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_974 1326-0144 138 µM 1.25204960625455 0.0814979731227575 no 333 0.105275894366346 594 5411856 SGTC_896 0964-0007 44.5 µM 1.25200960827631 0.0815047353193502 no 334 0.105283181434612 595 6756758 SGTC_2367 9070478 135.38 µM 1.24935563986043 0.0819543704857866 no 335 0.105767512859025 607 572802 SGTC_1525 8-methoxypsoralen 92.5 µM 1.24789627134504 0.0822024117731795 no 336 0.106034523156595 651 4114 Related to psoralen; DNA damaging agent. SGTC_6 0844-0013 19.835 µM 1.24248484538023 0.0831271006321525 no 337 0.107028864241657 823 1584900 SGTC_1086 cerivastatin 2.18 µM 1.24222954490422 0.083170918078871 no 338 0.107075940883771 557 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_2363 9053361 176 µM 1.24188617538271 0.0832298782782441 no 339 0.1071392807415 605 6469797 YMR079W SEC14 SGTC_2651 TUB2.036 5 µM 1.23774191437851 0.0839439724022714 no 340 0.107905886131399 777 15992207 YFL037W TUB2 SGTC_194 1486-1323 56.904 µM 1.23448958243449 0.0845075934793784 no 341 0.108510263126337 578 5178754 SGTC_1665 st014639 11.4 µM 1.23093847500072 0.0851262285628638 no 342 0.109172938069731 644 981133 YIL048W NEO1 SGTC_681 1642-0006 26.6 µM 1.23059937953548 0.0851854791113734 no 343 0.109236368712506 558 4446530 SGTC_3185 9108267 49.47 µM 1.22861348048346 0.0855330981453946 no 344 0.109608379397911 599 4910486 SGTC_1607 st000305 50.6 µM 1.22649059774606 0.0859058688695996 no 345 0.110007055687534 606 5457690 SGTC_1265 0819-1001 68.8 µM 1.22402232890916 0.0863408152535934 no 346 0.110471902168084 571 3106768 SGTC_586 0957-0265 8.15 µM 1.22165988807897 0.0867586535364549 no 347 0.110918135511762 517 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2525 harmine 47.85 µM 1.22106200788129 0.086864638133857 no 348 0.111031271506353 536 5280953 A monoamine oxidase inhibitor SGTC_3075 9116269 49.47 µM 1.22022296054075 0.0870135368634478 no 349 0.111190182550339 609 17015205 YNL244C SUI1 SGTC_3273 9137859 49.47 µM 1.21458439487951 0.0880191148603583 no 350 0.112262321815711 586 2377234 SGTC_791 1348-1292 225 µM 1.21127091455152 0.0886140668543311 no 351 0.112895796038731 698 5437054 SGTC_3021 9087658 49.47 µM 1.2107518393535 0.088707540151543 no 352 0.11299526403604 562 25237042 SGTC_508 roscovitine 141 µM 1.21063612489665 0.0887283876233337 no 353 0.113017446389541 616 160355 A CDKinase inhibitor. SGTC_2653 dihydrofissinolide 100 µM 1.20773558305896 0.0892521508339115 no 354 0.113574493186882 589 6857746 SGTC_1109 tnp00067 928.257 nM 1.20638094002146 0.0894975511005129 no 355 0.113835320860785 628 676295 SGTC_2794 7785382 27.27 µM 1.20275446728735 0.090156973899182 no 356 0.114535674771376 719 2205081 SGTC_165 k038-0023 64.381 µM 1.20240872469249 0.0902200302679367 no 357 0.114602605271821 634 46368543 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.20176317187538 0.0903378535558412 no 358 0.114727648961228 670 1377 SGTC_2565 isoliquiritigenin 100 µM 1.20136112989275 0.0904112901039392 no 359 0.114805573599694 498 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_624 k048-0052 28 µM 1.19895021204285 0.0908525958605486 no 360 0.115273652822332 600 6835531 SGTC_1526 st051518 75 µM 1.19447744890181 0.0916755410477638 no 361 0.116145628455553 581 673993 SGTC_245 methotrexate 289.6 µM 1.1933588111564 0.0918822203097475 no 362 0.116364439416194 681 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_3176 9106582 49.47 µM 1.19242759614094 0.0920545344421191 no 363 0.116546812515725 451 17018027 SGTC_3302 9125395 16.351 µM 1.19147166249456 0.0922316713282432 no 364 0.116734237377236 622 17599668 SGTC_2442 5158906 48.48 µM 1.19137191418715 0.092250169465066 no 365 0.116753806806465 648 1893835 SGTC_1642 st009582 77.7 µM 1.1870924519566 0.0930463760353374 no 366 0.117595577653388 586 6739311 SGTC_1654 st012436 41.8 µM 1.17794719996687 0.094764882081679 no 367 0.119408828209502 590 4323132 SGTC_3065 9113888 49.47 µM 1.17579527432687 0.0951726337376469 no 368 0.119838347628508 592 16648368 SGTC_1997 st073024 93.8 µM 1.17523243265266 0.0952794950768215 no 369 0.11995086902926 630 686268 SGTC_1935 st074532 41.6 µM 1.17492834918151 0.0953372652272944 no 370 0.120011691344315 740 2829742 SGTC_1714 st033236 13.627 µM 1.17149576181491 0.0959911817598295 no 371 0.120699780198483 658 2916566 SGTC_2190 6049624 200 µM 1.17092946525172 0.0960993788764883 no 372 0.120813565105191 566 2265554 SGTC_698 k064-0052 127 µM 1.17004864102086 0.0962678480780595 no 373 0.120990697467383 605 5088751 SGTC_2616 abietic acid 100 µM 1.1670194208622 0.0968488831374119 no 374 0.121601263352583 699 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_173 1273-0061 2.693 µM 1.16648496601837 0.0969516636568711 no 375 0.121709211756831 669 2847414 YPL266W DIM1 SGTC_3288 9119690 36.221 µM 1.16543493282815 0.0971538277391938 no 376 0.121921491985225 574 17595618 YKL019W RAM2 SGTC_599 1935-0052 86.5 µM 1.16335396758047 0.0975553921040859 no 377 0.122342958967118 677 9557311 SGTC_2948 9070189 9.45 µM 1.15912376800753 0.0983754443155625 no 378 0.123202869475553 584 6473636 YDL196W YDL196W SGTC_676 falcarinol 140 µM 1.15732595536269 0.098725486665352 no 379 0.123569606525204 675 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_471 1-acyl-paf 4 µM 1.15704997091885 0.0987793027072709 no 380 0.123625972403355 641 16759367 SGTC_3173 9105693 49.47 µM 1.1556580317298 0.0990510533834692 no 381 0.123910530477488 679 17096658 SGTC_3246 9135460 32.98 µM 1.15478804640161 0.0992211795807991 no 382 0.124088616675167 571 41446951 SGTC_112 phenothiazine 287.218 µM 1.15326805780631 0.0995189269305648 no 383 0.124400188296848 683 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_504 lovastatin 124 µM 1.152241180307 0.0997204490601521 no 384 0.12461098997933 580 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_3311 9131146 2.8755 µM 1.15183834306072 0.0997995862230234 no 385 0.124693754236189 670 4900406 YPR165W RHO1 SGTC_2976 9009005 19.48 µM 1.15104217677257 0.0999561275839326 no 386 0.124857442241296 659 2993148 SGTC_270 tamoxifen 5.46 µM 1.14852405100422 0.10045241912472 no 387 0.125376145056336 729 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_921 1561-0023 372 µM 1.14834367229489 0.100488038431153 no 388 0.12541335849243 667 24050882 SGTC_382 3229-0966 23.2 µM 1.14293524304214 0.101560322847652 no 389 0.126532739290347 709 5722370 SGTC_2271 7849410 118.62 µM 1.14157745747872 0.101830823532773 no 390 0.126814849298537 682 972430 SGTC_2028 5153890 36.43 µM 1.14103612809525 0.101938814319009 no 391 0.126927444467271 657 2830968 YPR165W RHO1 SGTC_885 0865-0106 16.8 µM 1.14004510567892 0.102136731103481 no 392 0.127133754940073 661 2793380 SGTC_96 0929-0093 37.281 µM 1.13943420153229 0.102258873779355 no 393 0.127261048803629 636 6991579 SGTC_1442 4112-3290 3 µM 1.13879163896833 0.102387460768688 no 394 0.127395034967136 695 704353 SGTC_349 k015-0014 24 µM 1.13863504925223 0.102418814672439 no 395 0.127427701677858 622 2196908 SGTC_1767 st044992 70.3 µM 1.13697932261733 0.102750767508455 no 396 0.12777346487867 658 9600693 SGTC_2606 farnesol 9.78 µM 1.13373146607145 0.103404192611102 no 397 0.128453603200197 687 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_3006 9075424 71.4286 µM 1.13283155391799 0.103585775366829 no 398 0.128642498924067 623 7465181 SGTC_2658 polymyxin b sulfate 77.05 µM 1.12921137988054 0.104318585679856 no 399 0.129404337141661 701 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_983 1491-0821 12.2 µM 1.12769333211001 0.104626990562064 no 400 0.129724727319893 672 46495113 SGTC_1111 tnp00062 510.699 nM 1.12068301897189 0.106059765880355 no 401 0.13121140643424 697 676306 SGTC_2304 7443016 91.4 µM 1.12048352433891 0.106100745236979 no 402 0.131253884819585 624 939854 SGTC_1234 0326-0494 15.5 µM 1.12045829225374 0.106105929121628 no 403 0.131259258163106 696 1547813 SGTC_2700 st077718 96.8 µM 1.11899966504795 0.106405912451992 no 404 0.131570140965147 637 904970 SGTC_3290 9121031 71.43 µM 1.11870046132034 0.106467522733425 no 405 0.131633974165737 626 17014854 SGTC_1865 st057639 52.2 µM 1.11854941577632 0.106498634929552 no 406 0.131666206882904 685 688818 SGTC_1210 3013-0140 750 nM 1.11836546212241 0.10653653436621 no 407 0.13170546945852 741 905973 SGTC_871 0574-0004 149 µM 1.11749985316663 0.106715003969072 no 408 0.131890331165451 736 9551173 SGTC_985 1493-0307 8.71 µM 1.11664935047724 0.106890569040082 no 409 0.132072140989001 628 3278274 SGTC_1540 guanosine 70.6 µM 1.11485236517468 0.107262196904647 no 410 0.132456846147668 657 6802 Guanosine is a purine nucleoside SGTC_1841 st054148 70 µM 1.11447424844511 0.107340512309941 no 411 0.132537892989422 639 675442 SGTC_766 1391-0721 126 µM 1.11345339341273 0.107552157305 no 412 0.132756877194055 692 1020919 YIL115C NUP159 SGTC_3208 9114115 49.47 µM 1.11043883774002 0.108178893652542 no 413 0.133404985097669 603 650895 SGTC_2357 9067248 200 µM 1.11011170952799 0.108247062510899 no 414 0.133475446005414 647 9150235 SGTC_2664 lyso-paf C-16 73.48 µM 1.1069385892014 0.108909900458027 no 415 0.134160240148667 738 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_2050 5263056 171 µM 1.10686256363789 0.108925817267538 no 416 0.13417667684916 765 763468 YGL055W OLE1 SGTC_1007 4101-0031 70 µM 1.10445217296651 0.109431327016567 no 417 0.134698519720739 719 1146276 SGTC_354 2783-3500 4.88 µM 1.10261395595722 0.10981797079263 no 418 0.135097423506508 688 6740761 SGTC_2281 7943571 200 µM 1.10260422956186 0.109820019211131 no 419 0.135099536343145 752 1244024 SGTC_1412 3909-8563 178 µM 1.10157456415582 0.110037026087571 no 420 0.135323335748064 777 23767530 SGTC_956 1185-0240 191 µM 1.10031264560078 0.110303400776917 no 421 0.135597962133331 683 1416193 SGTC_469 w7 172 µM 1.09650907615038 0.111109081734016 no 422 0.136428026805064 667 45115570 A P450 inhibitor. SGTC_1023 4482-3888 16 µM 1.0960866094536 0.111198828979235 no 423 0.136520437027757 702 3303168 SGTC_2025 5147754 141 µM 1.09578464059908 0.111263009914486 no 424 0.136586515823298 700 315777 YLR208W SEC13 SGTC_2175 5807670 165.306 µM 1.09497580538174 0.111435051663733 no 425 0.136763618164658 693 241186 SGTC_2452 5863136 48.41 µM 1.0893160242909 0.112644233344584 no 426 0.138007274364448 697 2184096 SGTC_2170 morpholine 200 µM 1.08921419069003 0.112666075024868 no 427 0.138029721260562 731 121171 Reacts with secondary amines. SGTC_2771 fluoxetine 41.05 µM 1.08431828772258 0.11371973834866 no 428 0.13911184977099 681 3386 A selective serotonin reuptake inhibitor. SGTC_287 k060-0039 29.6 µM 1.0832187199623 0.113957342717521 no 429 0.139355676251533 717 5861974 SGTC_773 4358-1457 44.6 µM 1.08252923339699 0.114106513420028 no 430 0.139508716455498 775 1186886 SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.08154028119158 0.114320716380347 no 431 0.139728426318194 787 91467 include heat shock SGTC_1804 st050076 49.1 µM 1.07945842805416 0.114772572563904 no 432 0.140191708242642 732 3895976 SGTC_1775 st081588 35.1725 µM 1.07745392419625 0.115208839800965 no 433 0.14063876228565 760 1426443 YGL099W LSG1 SGTC_1295 1013-0063 9.78 µM 1.07691537677919 0.115326251803537 no 434 0.14075903642475 745 6826038 SGTC_3131 9127911 49.47 µM 1.07656591323136 0.115402485965083 no 435 0.140837119671024 690 45595681 SGTC_1200 1643-0193 18.4 µM 1.07394267300884 0.115975879497257 no 436 0.141424187974268 771 5403974 SGTC_2425 5628681 7.85 µM 1.07354454328553 0.116063080028961 no 437 0.141513432197238 822 5714958 SGTC_1687 st020778 55.3625 µM 1.07215796500385 0.116367139188591 no 438 0.141824543549985 850 4259299 SGTC_1439 4092-1168 46 µM 1.07204255284903 0.116392473074004 no 439 0.141850459838222 753 2886240 SGTC_2699 st077704 54.6 µM 1.06972849238779 0.116901253636982 no 440 0.142370768717654 719 645852 SGTC_482 fipronil 114 µM 1.06816969568677 0.117244865580458 no 441 0.142721985924684 692 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_1341 1486-1360 280 µM 1.06682684641902 0.117541448452412 no 442 0.143025016634431 733 3976547 SGTC_411 enrofloxacin 100 µM 1.0636762078956 0.118239385190699 no 443 0.143737703062682 749 71188 A bacterial gyrase inhibitor. SGTC_151 3013-0144 2.285 µM 1.06142405114961 0.118740080810638 no 444 0.144248615742714 751 906558 YHR107C CDC12 SGTC_1974 st069448 26.9 µM 1.06133819526241 0.118759197737478 no 445 0.144268116760979 726 6323587 YNR016C ACC1 SGTC_472 calcifediol 10 µM 1.05882078413051 0.119320698729107 no 446 0.144840703115172 689 5283731 A vitamin D metabolite. SGTC_2222 6885208 172.143 µM 1.05817350297494 0.119465375149286 no 447 0.144988174494753 718 609514 SGTC_3230 9131665 49.47 µM 1.05775441356745 0.119559113493872 no 448 0.145083710374334 620 15943720 SGTC_1830 st055982 50.3 µM 1.05684613437763 0.119762447680325 no 449 0.145290907646544 750 455313 An antimicrobial agent. SGTC_2361 9034121 116 µM 1.05626213701761 0.119893314435012 no 450 0.145424234626895 719 6496917 SGTC_2232 chlorophetanol 41.5365 µM 1.05373706355754 0.120460313097526 no 451 0.146001657484113 861 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2330 7979373 200 µM 1.0483941588984 0.121666267223239 no 452 0.147228521803626 749 1863007 SGTC_2302 7771753 200 µM 1.04810707718976 0.121731304148441 no 453 0.147294637994522 752 2203047 SGTC_1549 4'-methoxyflavonol 74.6 µM 1.04695385798875 0.121992806336496 no 454 0.147560429994454 761 97141 SGTC_36 0335-0881 14.2 µM 1.04694039588817 0.121995861309344 no 455 0.147563534612505 802 23828853 SGTC_1905 st060207 84.5 µM 1.04658626161002 0.122076244782241 no 456 0.147645220470661 752 1948547 SGTC_87 0100-0052 35.5 µM 1.04359897030889 0.122755797967816 no 457 0.148335484758117 966 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 1.04237240671104 0.123035585259502 no 458 0.148619527184182 809 4174840 SGTC_1117 retinoic acid 1.10837 µM 1.04075968140304 0.12340413845985 no 459 0.14899354832749 822 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2648 atorvastatin 78.68 µM 1.04013268605361 0.123547633155373 no 460 0.149139129884806 747 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_46 0329-0187a 2.197 µM 1.03938248537564 0.123719478237315 no 461 0.149313443191203 855 46494817 SGTC_3268 9137683 49.47 µM 1.03777638874781 0.124087942015227 no 462 0.149687085860559 738 1953228 SGTC_2747 doxorubicin 7.63 µM 1.03532720901709 0.124651299251157 no 463 0.150258063536924 584 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_573 3702-0553 84.7 µM 1.03474099220433 0.124786404842606 no 464 0.150394943366141 751 1222756 SGTC_3144 9087057 49.47 µM 1.03149315914804 0.125536787939702 no 465 0.151154807276095 741 17249618 SGTC_904 1141-0088 396 µM 1.03121160893368 0.125601985630357 no 466 0.151220798938709 740 1378119 SGTC_2106 5357045 167.29 µM 1.02228700939995 0.127680879758193 no 467 0.153322539901679 797 668842 SGTC_1560 lithocholic acid 53.1 µM 1.02171456084347 0.127815037351916 no 468 0.153458008726501 706 9903 A bile acid which acts as a detergent. SGTC_143 4032-1194 15.74 µM 1.01836289894661 0.128602490150071 no 469 0.15425276347207 858 1806963 SGTC_1753 st043925 64 µM 1.01812757538196 0.128657904219262 no 470 0.154308666090668 810 670181 SGTC_155 k072-0202 43.6 µM 1.01747253039651 0.128812241666327 no 471 0.154464346758305 773 5857737 SGTC_1223 0764-0573 147 µM 1.01728383100733 0.128856725609606 no 472 0.154509213082748 810 1609797 SGTC_3080 9117754 49.47 µM 1.01203145584934 0.130099196829053 no 473 0.15576150676968 857 9550191 SGTC_2006 4011487 200 µM 1.01181131139992 0.130151453337445 no 474 0.155814140277235 812 45595294 SGTC_641 4092-0595 30 µM 1.01119790702772 0.130297136033507 no 475 0.15596085867079 805 786260 SGTC_1457 k015-0032 57.3 µM 1.00672579185826 0.13136266667458 no 476 0.157033282088597 791 4302660 SGTC_2799 7812892 81.82 µM 1.00572997287931 0.131600748207834 no 477 0.157272740483362 835 20205235 SGTC_1718 roemerine 11.9335 µM 1.00551468875373 0.131652257707256 no 478 0.157324540061268 802 235224 An aporphine alkaloid with mutagenic activity. SGTC_500 h-89 112 µM 1.00439507313385 0.131920364486104 no 479 0.157594111927486 860 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_1279 0874-0590 65.2 µM 1.00216489291009 0.132455532275051 no 480 0.15813198025457 823 3523074 SGTC_548 1436-0017 110 µM 1.00162565587455 0.132585155198415 no 481 0.158262212536449 884 9677137 SGTC_300 r073-0011 5.04 µM 0.998862828241158 0.133250660222256 no 482 0.158930572659197 885 2735780 SGTC_1120 ficusin 1.78878 µM 0.995714333476802 0.134011861951157 no 483 0.159694481888907 823 6199 A DNA cross-linker. SGTC_496 calpeptin 138 µM 0.995620202326881 0.134034665651609 no 484 0.159717357557399 709 73364 A calpain inhibitor. SGTC_1336 1486-0901 104 µM 0.994288187590271 0.134357638104542 no 485 0.160041292420438 810 5006114 SGTC_1903 st060211 78.3 µM 0.993562797079119 0.134533747485432 no 486 0.160217881892234 852 688960 SGTC_934 2950-0684 338 µM 0.992173731785522 0.134871425065155 no 487 0.160556392056634 859 1121253 SGTC_3116 9124943 49.47 µM 0.991641183815755 0.135001039930275 no 488 0.160686295865112 740 41905195 YPL160W CDC60 SGTC_463 ikarugamyin 104 µM 0.991393359420506 0.135061386105513 no 489 0.160746770778752 784 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_951 1171-0579 82.7 µM 0.988689938249954 0.13572088098168 no 490 0.161407433581473 863 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2822 7994718 71.43 µM 0.986320002907692 0.136300834106233 no 491 0.16198805351262 721 1018011 SGTC_2069 5228469 200 µM 0.983911572120965 0.136891942381885 no 492 0.162579496676579 773 2835210 SGTC_1503 4585-0012 61.3 µM 0.982934279116224 0.137132301277508 no 493 0.162819892697292 807 2922052 SGTC_322 k048-0136 19.3 µM 0.98292981500367 0.137133399858207 no 494 0.162820991316582 770 6823282 SGTC_2471 5466956 24.79 µM 0.980404089434277 0.137755923932885 no 495 0.163443345967918 813 724419 SGTC_1169 aniline yellow 25.8 µM 0.977568674488671 0.138457072444004 no 496 0.164143848412527 796 6051 A DNA damaging agent. SGTC_1512 0259-0544 12.2 µM 0.974755503017657 0.139155120082825 no 497 0.164840777037812 863 18476 SGTC_2022 5136654 200 µM 0.972213496322659 0.139787938785919 no 498 0.165472173834432 794 1713771 SGTC_820 1582-0060 59.9 µM 0.968192744811754 0.140792871795992 no 499 0.166474058816624 842 3848840 SGTC_2628 lathosterol 100 µM 0.967535094674873 0.140957707935558 no 500 0.166638303003553 829 6710616 SGTC_2355 9061122 103.12 µM 0.966254412819563 0.141279078843719 no 501 0.166958445642912 830 5302957 SGTC_3011 9081274 71.4286 µM 0.965819107705441 0.141388426170924 no 502 0.167067352734954 866 6625322 SGTC_543 3844-1095 191 µM 0.961874218534192 0.142381985516365 no 503 0.168056395296044 869 4230703 SGTC_2216 7189485 200 µM 0.961772032622522 0.142407784652029 no 504 0.168082064793612 878 731273 SGTC_301 4119-0100 24.5 µM 0.960442704876824 0.142743691536867 no 505 0.168416226963296 855 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2269 7935389 174.42 µM 0.958700063744514 0.143184849019943 no 506 0.168854933175907 804 97605 SGTC_2603 homopterocarpin 100 µM 0.957526303086001 0.143482510362694 no 507 0.169150838377218 831 101795 A weak amylase inhibitor. SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.956343529726329 0.143782879574404 no 508 0.169449352280643 935 551469 SGTC_1423 4048-0112 5.59 µM 0.953468406141022 0.144514794758606 no 509 0.170176398223843 873 X1423 SGTC_1983 st071813 46.9 µM 0.944790519516649 0.146739110490383 no 510 0.172382916449418 842 11838595 SGTC_347 4534-1311 26.2 µM 0.944339845338132 0.146855251380312 no 511 0.172498005296116 825 2862016 SGTC_90 0870-0863 4.608 µM 0.939407470195451 0.148130377959876 no 512 0.173760789544653 890 1738164 SGTC_616 4092-0450 108 µM 0.936922854649915 0.14877550308202 no 513 0.174399121029086 896 787165 SGTC_334 1502-1024 68.5 µM 0.933031453599571 0.149789665318195 no 514 0.175401864292978 892 3296216 SGTC_1170 0310-0127 64.8 µM 0.932154329153831 0.15001889354143 no 515 0.175628387091087 898 774975 SGTC_1805 st050013 60.3 µM 0.931848063472706 0.150098988260003 no 516 0.175707525736189 846 4037144 SGTC_1964 st076914 61 µM 0.931025344610907 0.150314287137029 no 517 0.175920227036779 894 24208661 SGTC_47 0149-0135 24.25 µM 0.930236088883508 0.150521022294685 no 518 0.1761244301358 904 5239155 SGTC_75 0159-0059 199.013 µM 0.93006741539062 0.150565228649622 no 519 0.176168090259183 858 5377270 SGTC_688 0527-0193 473 µM 0.9271892396581 0.151320880512684 no 520 0.176914144331194 856 4007154 SGTC_2725 haloperidol 53.21 µM 0.926808303742105 0.151421082175993 no 521 0.177013036422224 895 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2332 7982454 138.89 µM 0.926159585744505 0.15159182295831 no 522 0.177181525902849 881 2981748 SGTC_1723 st034307 2.5525 µM 0.925414712675161 0.151788029270165 no 523 0.177375114324554 885 867466 SGTC_2110 5483698 200 µM 0.925060594524119 0.151881366353433 no 524 0.177467194505148 870 2848765 YHR062C RPP1 SGTC_829 1635-0120 117 µM 0.92394868426679 0.152174687119733 no 525 0.177756516955962 922 285054 SGTC_2132 5317594 122.667 µM 0.922343021741231 0.152598922557882 no 526 0.178174840037728 831 794577 SGTC_931 2812-0076 566 µM 0.922180245061144 0.152641973886295 no 527 0.178217282842819 897 3450959 SGTC_2810 7959871 45.46 µM 0.921573048711643 0.15280263682419 no 528 0.17837566097295 922 2974535 SGTC_713 1488-1073 324 µM 0.921113243030279 0.152924375078633 no 529 0.178495653424573 895 3312542 SGTC_1698 5-fluorocytosine 1.055 µM 0.918219265770068 0.153692060893738 no 530 0.179252042166438 912 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1861 st057647 17.4 µM 0.916465455469971 0.154158533940324 no 531 0.179711408937988 899 688668 SGTC_2043 5101342 149 µM 0.915784118455201 0.154340006169158 no 532 0.179890067447737 857 678451 SGTC_2820 7989630 71.43 µM 0.915093830159632 0.154524006539106 no 533 0.180071186857417 782 2984098 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.914843111762217 0.154590872870494 no 534 0.180136999252887 930 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1625 st003711 30.1 µM 0.914023315021329 0.154809645266388 no 535 0.180352297409825 893 24207034 YER133W GLC7 SGTC_1985 st071382 65.5 µM 0.912114318323126 0.155319875761196 no 536 0.180854270846691 917 6123237 SGTC_2154 5570129 200 µM 0.912102717205708 0.155322979859416 no 537 0.180857324051864 956 673366 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.911504545858292 0.155483087387188 no 538 0.181014795755094 974 5024745 SGTC_2074 5212007 75.395 µM 0.91101071157374 0.155615349909348 no 539 0.181144864905686 847 758611 SGTC_922 1866-0035 480 µM 0.908918032565065 0.15617665072378 no 540 0.181696697209486 977 3156169 SGTC_3200 9114385 49.47 µM 0.907671327724876 0.15651167663326 no 541 0.182025948435481 841 17018030 YLR208W SEC13 SGTC_191 3914-0123 66.505 µM 0.905100863845648 0.157203927730582 no 542 0.182705977269135 764 3144412 SGTC_661 1304-0007 33.6 µM 0.904263515217036 0.15742986800269 no 543 0.182927844032099 876 3117130 SGTC_2973 9094665 17.96 µM 0.904225361173615 0.157440168121073 no 544 0.182937957461702 950 25237061 YIL048W NEO1 SGTC_3234 9132280 49.47 µM 0.903635132310646 0.157599563543931 no 545 0.183094452903502 892 17612295 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.902162217358176 0.157997796792604 no 546 0.183485351084238 957 5106787 A p450 inhibitor. SGTC_2693 st077581 40.7 µM 0.896156977234277 0.159628270402936 no 547 0.185084464931538 981 25238761 SGTC_639 0833-0042 114 µM 0.895827833051046 0.159717953015729 no 548 0.185172361096355 944 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_14 0354-0009 295 µM 0.894746922813767 0.160012702779277 no 549 0.185461194623077 927 1713507 SGTC_2516 gossypol 71.55 µM 0.893447265627337 0.160367572570729 no 550 0.185808850263783 951 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2581 avocatin a 64 µM 0.891534766680757 0.16089071256623 no 551 0.186321174318256 905 6710728 A skin care supplement. SGTC_1114 scopoletin 1.73284 µM 0.891268137906169 0.160963733892189 no 552 0.186392668818367 925 5280460 A coumarin with genotoxic properties. SGTC_1283 0922-0125 16.4 µM 0.890303281243375 0.161228158857162 no 553 0.186651529866214 972 3360884 SGTC_374 0880-0231 82.3 µM 0.889388360823287 0.161479160094197 no 554 0.18689719902698 931 6833587 SGTC_2093 5331342 194.4 µM 0.888511140404302 0.161720057762382 no 555 0.187132932997168 945 33839 SGTC_476 mead acid 10 µM 0.888186970135895 0.161809138938804 no 556 0.187220093243947 904 5312531 An omega 9 fatty acid. SGTC_294 k038-0071 157 µM 0.886497420582197 0.162273940409199 no 557 0.187674771751222 932 24152826 SGTC_1738 st035555 74 µM 0.886376372675002 0.162307274481365 no 558 0.187707373393876 921 5331140 SGTC_2407 paclitaxel 400 µM 0.886039192453755 0.16240015039015 no 559 0.187798204056019 933 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_2998 9066762 71.4286 µM 0.885296050960114 0.162604969974817 no 560 0.187998489657623 934 4945196 SGTC_3245 9134821 49.47 µM 0.885102569212989 0.162658323654673 no 561 0.188050656951012 959 17014901 SGTC_828 2074-0507 139 µM 0.885056570850488 0.162671009637173 no 562 0.188063060521109 941 X828 SGTC_2333 9017922 200 µM 0.883694205142097 0.16304703107026 no 563 0.188430654678171 938 3163164 SGTC_3224 9130643 49.47 µM 0.881330462262025 0.163700778281557 no 564 0.189069491472343 906 17644395 SGTC_2704 st078022 71.1 µM 0.880563834635385 0.163913171640049 no 565 0.189276970178258 944 54697681 SGTC_842 0271-0008 11.1 µM 0.879748126624175 0.164139358931589 no 566 0.189497885760328 972 1221709 SGTC_1244 0416-0015 52.5 µM 0.879583313366477 0.164185084494818 no 567 0.189542540865507 911 96201 SGTC_201 4262-0159 12.803 µM 0.879532307632687 0.164199237129137 no 568 0.189556361856866 888 1341029 SGTC_86 0417-1630 471.922 µM 0.879482228401187 0.164213133455251 no 569 0.189569932397735 1033 3634867 SGTC_2947 9072639 7.68 µM 0.87888141177274 0.164379911605478 no 570 0.189732789135389 1017 16488146 SGTC_1212 0520-0165 585 µM 0.878765841740959 0.16441200479085 no 571 0.189764125294225 904 5403258 SGTC_2910 7948405 25.97 µM 0.876106580890809 0.165151589320553 no 572 0.190486047751918 909 2971328 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.874038840858749 0.165728148010497 no 573 0.191048550949299 997 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_840 0245-0196 390 µM 0.867625876808955 0.167524574072019 no 574 0.192799587852228 987 3827528 SGTC_761 k216-0224 480 µM 0.866585419439965 0.16781720967624 no 575 0.193084602628768 1019 1340404 SGTC_3301 9125354 19.7965 µM 0.866148794816194 0.167940111253536 no 576 0.193204284760274 875 41905162 SGTC_1583 clindamycin 39.6 µM 0.865427198541091 0.168143353924541 no 577 0.193402179018862 842 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_1616 st002734 56.1 µM 0.865195076933092 0.168208766237772 no 578 0.193465863517942 969 4026101 SGTC_3009 9080819 71.4286 µM 0.864311550933228 0.16845789527864 no 579 0.193708383239043 944 17027216 SGTC_252 miconazole 1.30953 nM 0.862979178549349 0.168834034574286 no 580 0.194074457484579 934 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1240 0356-0016 42.1 µM 0.862329599266171 0.169017611483542 no 581 0.194253084525448 925 4305613 SGTC_1143 3454-2408 5.08 µM 0.860048653876324 0.169663242051159 no 582 0.194881111636251 934 X1143 SGTC_1925 st057770 10.1 µM 0.859619189264012 0.169784980437095 no 583 0.194999496825488 873 5989122 SGTC_796 1234-0020 70.7 µM 0.858941271874583 0.169977260575061 no 584 0.195186458872758 946 46495034 SGTC_10 0279-0212 42.575 µM 0.858802688369528 0.170016584688852 no 585 0.195224692063119 1042 39851 YBR002C RER2 SGTC_95 0471-0001 561.058 µM 0.858369279305517 0.17013960540938 no 586 0.195344292742451 945 4015405 SGTC_3135 9127742 49.47 µM 0.858064875257053 0.170226042875963 no 587 0.195428320661699 895 3643468 SGTC_1155 4088-0394 48.2 µM 0.857767969493431 0.170310378256666 no 588 0.195510299895281 934 2326248 SGTC_1186 1319-0216 26 µM 0.856128475604866 0.170776554480224 no 589 0.195963359718856 1015 4565136 SGTC_121 0557-0495 61.343 µM 0.8553826893759 0.170988882463905 no 590 0.196169661830311 1163 3104427 SGTC_1348 1493-0373 93.8 µM 0.855221345390719 0.17103483987874 no 591 0.196214310715344 958 3010129 SGTC_340 k038-0059 454 µM 0.853070869333615 0.171648138405996 no 592 0.196810002353091 979 23733424 SGTC_1337 1486-1011 40.3 µM 0.852842583625237 0.171713326047636 no 593 0.196873302764532 1009 X1337 SGTC_1746 st038117 42 µM 0.851133652894675 0.172201818328797 no 594 0.197347556604997 934 2898218 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.848487736170787 0.172959892554897 no 595 0.198083199753968 1043 1273210 SGTC_1241 0364-0022 50.8 µM 0.847808266166176 0.173154908221855 no 596 0.198272379393006 972 4563895 SGTC_348 k064-0012 10.7 µM 0.847168770766338 0.173338578593727 no 597 0.198450528787849 912 5066323 SGTC_1929 genistein trimethyl ether 50.5 µM 0.8457165849805 0.173756123354036 no 598 0.198855434397477 1005 136420 SGTC_2359 9039622 200 µM 0.845261787759623 0.173887021957056 no 599 0.198982345534544 1007 6463596 SGTC_566 0958-0068 16.5 µM 0.842241755367915 0.174757830348129 no 600 0.199826322892652 927 6815365 SGTC_1851 st056236 18.9 µM 0.84152213697628 0.174965735742545 no 601 0.200027744430406 1026 5393171 SGTC_955 1216-0110 33 µM 0.840657935543119 0.175215620031084 no 602 0.200269796076018 938 3619719 SGTC_2748 diazoxide 86.69 µM 0.839744723825059 0.175479921491015 no 603 0.200525766028843 905 3019 A potassium channel activatior. SGTC_1838 st055369 84.5 µM 0.839228225239672 0.175629518177766 no 604 0.200670625664375 1007 676036 SGTC_1434 4073-0095 163 µM 0.837291863408472 0.17619107776267 no 605 0.201214265856257 1036 24133745 SGTC_2519 cryptotanshinone 88.04 µM 0.835578562329773 0.176688894545291 no 606 0.201696016547107 992 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_387 norethindrone acetate 66.7 µM 0.834657754853133 0.176956811430808 no 607 0.20195521688389 936 541197 SGTC_209 4077-0173 175.592 µM 0.832890824583106 0.177471633546845 no 608 0.202453152435015 896 15993494 SGTC_798 1287-0182 476 µM 0.832821220098165 0.177491933213344 no 609 0.202472782570178 1060 1649755 SGTC_2849 9019321 12.99 µM 0.832790643176435 0.177500851224355 no 610 0.202481406355662 920 16489627 SGTC_3263 9137018 49.47 µM 0.832618613488592 0.17755103037115 no 611 0.202529928973336 963 43844957 SGTC_195 4234-0266 16.654 µM 0.831337636280185 0.17792495867044 no 612 0.202891459381723 1014 2303354 SGTC_2862 9027634 71.43 µM 0.829780593125424 0.178380141187663 no 613 0.203331422588306 919 5012562 SGTC_726 3448-4391 34.2 µM 0.828585346401147 0.178730054254876 no 614 0.203669541335354 1040 1356692 SGTC_2889 9059656 51.95 µM 0.827784785497731 0.178964663019788 no 615 0.203896196285569 1035 3949838 SGTC_2214 7179297 48.276 µM 0.826773978212277 0.179261162318121 no 616 0.204182590847901 1015 769744 SGTC_1740 st038286 13.222 µM 0.821965929593612 0.180675729313839 no 617 0.205548143960059 984 716786 SGTC_2430 5571206 200 µM 0.819669526121946 0.181353812854762 no 618 0.206202263419193 1106 1731771 SGTC_2739 tacrine 100.86 µM 0.819467832344108 0.181413445153848 no 619 0.20625977381063 1001 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_1104 tacrolimus 29.8 µM 0.818899891433044 0.181581427144133 no 620 0.206421765939379 1040 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1683 st010134 710 nM 0.816759208234381 0.182215459498126 no 621 0.207033023937798 1011 3818134 SGTC_2823 7987624 58.44 µM 0.815895241975254 0.182471742397549 no 622 0.207280026844183 1001 2239440 SGTC_1027 k015-0025 8.67 µM 0.811034712516654 0.183917740162743 no 623 0.208672868299838 1045 3598955 SGTC_1766 st045414 44.774 µM 0.807343140289516 0.18502072977271 no 624 0.209734407952306 1099 253960 SGTC_1842 st055362 61.2 µM 0.805638988139024 0.185531289931611 no 625 0.210225519113525 1052 676032 SGTC_1579 chlormadinone acetate 49.4 µM 0.80557456858732 0.185550607020027 no 626 0.210244097102861 1053 45114258 A steroidal progestin. SGTC_2638 epoxomicin 18 µM 0.802025122109816 0.186616885726926 no 627 0.211269213182725 1045 9915668 A protesome inhibitor. SGTC_3034 9090421 49.47 µM 0.801064033546319 0.186906254944647 no 628 0.211547288265814 999 17173761 SGTC_2878 9043973 25.97 µM 0.800492165375518 0.187078567474944 no 629 0.211712850502036 1027 6465167 SGTC_1562 morin hydrate 59.1 µM 0.799127852906237 0.187490052144237 no 630 0.212108140358138 1017 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2987 9018338 71.43 µM 0.797861985647443 0.187872345003813 no 631 0.212475292794913 1049 5055682 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.795767227610617 0.188506019902965 no 632 0.213083671751408 978 688803 SGTC_1678 st019265 80.2 µM 0.795345889991539 0.188633635694824 no 633 0.213206163148881 1075 5367020 SGTC_376 3970-0862 59.1 µM 0.794946898566391 0.188754532301825 no 634 0.21332219590087 1068 3135186 SGTC_2 0422-0095 29 µM 0.79374994247275 0.189117503046564 no 635 0.213670509688722 965 6790840 SGTC_2966 9084041 48.03 µM 0.793143888963059 0.189301449450573 no 636 0.213846997309925 1021 17741380 SGTC_693 4161-2696 114 µM 0.790020414389666 0.190251216725728 no 637 0.214757923132766 1019 805759 SGTC_1860 st056228 74.6 µM 0.78977056156106 0.190327316707011 no 638 0.214830887126562 1057 688679 SGTC_405 ebelactone b 50 µM 0.788994034247528 0.190563950126314 no 639 0.215057746668584 1031 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_1629 st005085 44.9 µM 0.788876808169569 0.190599688453718 no 640 0.215092005907502 1045 24207091 SGTC_2727 riluzole 51.77 µM 0.787730310052455 0.190949434408033 no 641 0.215427236173005 1051 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_1416 3966-0321 25.3 µM 0.787440643916087 0.191037861013091 no 642 0.215511981027422 1088 582530 YLR208W SEC13 SGTC_2436 5633522 8.09 µM 0.786489301562636 0.19132845466797 no 643 0.2157904421654 1073 5724242 SGTC_1710 st031758 61.5 µM 0.785814568179989 0.191534720451437 no 644 0.215988065259482 1037 5394341 SGTC_709 3807-1509 243 µM 0.785132647320877 0.191743321799083 no 645 0.216187899989273 1064 1886677 YPL242C IQG1 SGTC_513 4245-1575 41.7 µM 0.78453453159776 0.191926401414982 no 646 0.216363263992417 1104 719745 SGTC_1236 0330-0013 258 µM 0.7837289270126 0.192173161169378 no 647 0.216599592591347 1020 4617066 SGTC_758 0868-0029 16 µM 0.783384055422166 0.19227885595334 no 648 0.216700808224582 1097 762687 SGTC_2957 9076800 11.52 µM 0.781443438419658 0.192874270718975 no 649 0.217270865599934 1002 16459615 SGTC_1392 3455-1037 33.9 µM 0.777369191603743 0.194127978963577 no 650 0.218470491781049 1055 981132 SGTC_1002 4049-0206 172 µM 0.77501942275552 0.194853290695496 no 651 0.219164091356891 1129 4662749 SGTC_2596 sinensetin 100 µM 0.774905486237095 0.194888501741116 no 652 0.219197755036543 1038 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_690 glyoxal 20.3 µM 0.774479774362441 0.195020098362346 no 653 0.219323562150816 1008 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_1215 3852-0577 11.2 µM 0.774323235251716 0.195068501521922 no 654 0.219369833293962 1140 2884876 SGTC_2133 5320837 200 µM 0.77346650556832 0.195333538604065 no 655 0.219623171978156 1032 2841355 SGTC_2166 5933061 31.504 µM 0.772965449221351 0.19548864626037 no 656 0.219771414345645 1265 2877375 SGTC_2120 5538279 151.968 µM 0.771813780944694 0.19584544163753 no 657 0.220112364206636 1075 2058197 SGTC_1401 3807-4679 7.6 µM 0.771359743959399 0.195986214204335 no 658 0.220246864591093 1036 3291456 SGTC_637 1181-0519 7.26 µM 0.770845673063437 0.196145674148615 no 659 0.22039920582348 1138 6252091 YGR060W ERG25 SGTC_2905 7799065 20.05 µM 0.770071709795408 0.196385898604958 no 660 0.220628678180651 1049 1296806 SGTC_1788 fluconazole 20 µM 0.769772206663973 0.196478906894142 no 661 0.220717514576344 1005 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_3089 9117425 49.47 µM 0.769569008517581 0.196542023640286 no 662 0.220777797365191 1045 9401657 SGTC_3232 9132874 49.47 µM 0.767587759090817 0.197158076521886 no 663 0.221366068515815 1082 3784940 SGTC_1256 0570-0116 285 µM 0.766950948650686 0.19735633524338 no 664 0.221555339990456 1079 410638 SGTC_1369 1866-0067 208 µM 0.765786662066605 0.197719125161995 no 665 0.22190162586981 1112 3531355 SGTC_1726 st035556 14.5795 µM 0.764222715922026 0.198207082174957 no 666 0.222367265879195 1104 5919439 SGTC_1025 k007-0731 70 µM 0.764116438139611 0.198240267595893 no 667 0.222398928605114 1105 6256118 SGTC_3168 9103419 49.47 µM 0.763538468280146 0.198420798388327 no 668 0.222571164839965 1040 16649256 SGTC_1760 st045453 10.4495 µM 0.763135899080293 0.198546600794896 no 669 0.222691176228551 1111 3323419 YIL048W NEO1 SGTC_1671 st016596 74.5 µM 0.76237788850726 0.198783608763636 no 670 0.222917249634452 1155 2829167 SGTC_302 1094-0063 18.9 µM 0.761606435913075 0.199024994711879 no 671 0.223147466245385 1045 5440289 SGTC_1016 4226-1401 38 µM 0.760359693304271 0.199415471101908 no 672 0.223519804729189 1119 2901613 SGTC_3105 9121040 49.47 µM 0.760207352544912 0.199463215413702 no 673 0.223565325366862 915 41448907 SGTC_1961 st076550 68.7 µM 0.756260134838272 0.200702689596359 no 674 0.224746622309052 1049 1579337 SGTC_3058 9093861 49.47 µM 0.753627859215585 0.201531819825755 no 675 0.225536355480021 1103 17217477 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.750286318573671 0.202587309781436 no 676 0.226541140394858 1144 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2292 7671323 168.05 µM 0.748466023261804 0.203163672730852 no 677 0.227089555839107 1097 937504 SGTC_850 0388-0143 75.9 µM 0.748088684921532 0.203283272330616 no 678 0.227203333272807 1071 67273 SGTC_1000 4048-0884 8.67 µM 0.747453178441063 0.203484794784127 no 679 0.227395027792988 1073 13040088 SGTC_1195 1502-0147 41.1 µM 0.747074840640947 0.203604824264267 no 680 0.227509193066008 1146 817940 SGTC_2898 9056270 58.44 µM 0.740958654953489 0.205551065747874 no 681 0.229359254708844 1059 19154699 SGTC_2356 9061756 188.97 µM 0.740692725965636 0.205635937253285 no 682 0.229439885405097 1105 20104043 SGTC_2842 9000675 19.48 µM 0.740327290125955 0.205752600397304 no 683 0.229550712873219 1112 2989072 SGTC_2618 avocadyne 43.43 µM 0.739847837423886 0.205905722278243 no 684 0.22969616425876 1091 3015189 SGTC_2455 5377712 9.75 µM 0.739701843692189 0.205952361436085 no 685 0.229740464571926 1086 2243908 SGTC_378 3970-0959 8.33 µM 0.738679260906957 0.206279211348268 no 686 0.230050891010009 1104 6615653 SGTC_124 0136-0217 7.121 µM 0.738592957214885 0.206306810808978 no 687 0.230077101040872 1264 3976905 SGTC_1776 st049249 45.9 µM 0.737112720907687 0.206780523074276 no 688 0.23052690194077 1155 1822314 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.736898002227444 0.206849291807469 no 689 0.230592189514416 1152 688761 SGTC_2563 tomatine 8.54 µM 0.736598406229564 0.206945267126872 no 690 0.230683302232494 1131 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1345 1488-0192 31.4 µM 0.735876125465788 0.207176757470906 no 691 0.2309030439255 1172 658348 SGTC_1478 0453-0656 35.7 µM 0.733471773732869 0.207948452799772 no 692 0.231635368663187 1162 5258496 SGTC_226 1,3-diallylurea 8.28947 mM 0.733056219404644 0.208081999982009 no 693 0.231762070524602 1115 74537 YKL182W FAS1 SGTC_1939 st074455 53.6 µM 0.731669826974666 0.208527912562562 no 694 0.232185058566534 1138 1644229 SGTC_708 3448-5400 146 µM 0.731153854514119 0.208694011218119 no 695 0.232342591291504 1151 3462195 SGTC_2814 7977482 42.97 µM 0.729186146170708 0.209328159021514 no 696 0.232943902214745 1172 6456762 SGTC_170 4197-0004 226 µM 0.726641656278604 0.210149869608163 no 697 0.23372275144911 1120 218692 SGTC_537 1334-0398 209 µM 0.725995608578412 0.210358803692126 no 698 0.23392073133142 1150 5846986 SGTC_2026 5148700 152 µM 0.72403526086987 0.210993533015541 no 699 0.234522043875456 1145 79838 SGTC_2434 5670830 169.91 µM 0.723742165771916 0.211088528922843 no 700 0.234612020611922 1120 1549830 SGTC_2079 5212404 121 µM 0.721640519025475 0.211770433750414 no 701 0.235257760305898 1161 758462 SGTC_2722 naftopidil 47.16 µM 0.719323789979263 0.212523616252444 no 702 0.235970720555336 1150 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_2550 chrysin dimethyl ether 71.87 µM 0.716835050849705 0.213334460965161 no 703 0.236737940716657 1029 88881 An O-methylated flavonoid and antioxidant. SGTC_3101 9120531 49.47 µM 0.716054194381418 0.213589239482965 no 704 0.236978942988298 1191 24824904 SGTC_395 anisomycin 6.25 µM 0.715440909256303 0.213789466922015 no 705 0.237168320821825 1127 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_3343 9148379 18.9835 µM 0.71456225332048 0.214076523951513 no 706 0.237439787992757 1202 1955036 SGTC_1509 1326-1131 80 µM 0.714371600343058 0.214138839912461 no 707 0.237498714137437 1134 768313 SGTC_3098 9119039 49.47 µM 0.71110568123382 0.215207961334128 no 708 0.238509374851998 1212 17161528 SGTC_3039 9090270 49.47 µM 0.711012081610564 0.215238647422431 no 709 0.23853837455123 1174 17173750 SGTC_1734 st037168 69.4 µM 0.709855112430646 0.215618162632366 no 710 0.238896994281595 1115 708907 SGTC_1133 3473-0247 50 µM 0.709789537914439 0.215639684348349 no 711 0.238917328899478 1157 711311 SGTC_146 3448-8650 53.125 µM 0.709538284374905 0.2157221579004 no 712 0.238995251230859 1187 2891488 YIL048W NEO1 SGTC_1590 st077108 57.8 µM 0.708679397180463 0.216004224232249 no 713 0.239261726480895 1156 5489485 SGTC_133 0724-0033 378.92 µM 0.708540379272105 0.216049899053647 no 714 0.239304872935145 1090 280309 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.70825130695099 0.216144892687871 no 715 0.239394604807952 1216 6708784 An antioxidant flavonoid SGTC_1300 1094-0077 113 µM 0.705400574948326 0.217082981891822 no 716 0.240280493156549 1134 5532636 SGTC_1672 st016598 6.51 µM 0.704665908390942 0.217325119020313 no 717 0.240509085956002 1133 4665860 YNL267W PIK1 SGTC_2928 9011484 9.79 µM 0.704423558053132 0.217405028931096 no 718 0.240584519660259 1165 2994751 SGTC_1550 gossypolone 36.6 µM 0.704323412643074 0.217438054720039 no 719 0.24061569457303 1195 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_913 3487-1245 167 µM 0.70431727981462 0.217440077288252 no 720 0.240617603772344 1150 4016153 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.702676668155595 0.217981530653526 no 721 0.241128635576874 1130 279621 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.702240958791261 0.218125458958556 no 722 0.241264453161514 1030 4000243 SGTC_64 000l-0018 272.079 µM 0.702239713214446 0.218125870489676 no 723 0.241264841487333 1151 6811119 SGTC_2256 7954252 200 µM 0.701074061675454 0.218511190899735 no 724 0.241628398349665 1144 2972920 SGTC_483 fpl-64176 144 µM 0.700375043368954 0.218742447845182 no 725 0.241846558829637 1193 3423 SGTC_2650 prasterone 100 µM 0.69948031745622 0.219038656364095 no 726 0.242125954653385 1145 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_1886 st057356 49.9 µM 0.699382816419349 0.219070949050524 no 727 0.242156411847332 1162 24207747 SGTC_707 0865-0008 204 µM 0.697728121700072 0.219619407095973 no 728 0.242673618933514 1199 723043 SGTC_788 1182-0090 188 µM 0.696403328134698 0.220059085337482 no 729 0.243088139687535 1250 5715185 SGTC_2886 9058944 51.95 µM 0.696366006192001 0.220071479214714 no 730 0.243099823064908 1066 4949929 SGTC_1428 4049-0204 61.7 µM 0.695895607345734 0.22022772367006 no 731 0.24324710421649 1228 X1428 SGTC_2103 5378138 10 µM 0.694053622787229 0.220840156500339 no 732 0.243824290677145 1239 244142 SGTC_2851 9015922 71.43 µM 0.692780350813607 0.221264070147268 no 733 0.244223702529703 1182 2996893 SGTC_367 0335-0881 7.1 µM 0.692694051285282 0.221292818898878 no 734 0.244250786530697 1166 23828853 SGTC_1563 conessine 56.1 µM 0.692453075617392 0.221373105846387 no 735 0.244326422228161 1270 441082 An anti-amoebic, histamine inhibitor. SGTC_1486 3970-0793 4.53 µM 0.692130021794845 0.221480765270275 no 736 0.244427839824797 1223 2844330 SGTC_2695 st077686 51.995 µM 0.692060637753652 0.221503891779179 no 737 0.244449624796944 1192 2876092 SGTC_2052 5265182 7.135 µM 0.690139035621027 0.222144932435382 no 738 0.245053378570673 1195 1239884 SGTC_401 neomycin 50 µM 0.690083131261888 0.222163597797002 no 739 0.245070955323576 1156 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_2557 derrustone 83.84 µM 0.689987358421267 0.222195576537413 no 740 0.245101068604194 1209 629853 An antioxidant. SGTC_2036 5160441 105 µM 0.689898268518592 0.222225326189819 no 741 0.245129082395232 1220 134534 YIL048W NEO1 SGTC_2080 5212524 12.4 µM 0.689344231612947 0.22241038588171 no 742 0.245303334656557 1180 260183 SGTC_2521 angolensin 13.4 µM 0.687266579098442 0.223105146783654 no 743 0.245957377685758 1230 821428 A flavenoid. SGTC_1914 st062367 72.6 µM 0.686542433267426 0.223347589127508 no 744 0.246185557813525 1200 978205 SGTC_234 nsc-17383 10.7 µM 0.686310685791735 0.223425209299691 no 745 0.246258605982082 1240 408974 SGTC_1153 4055-0057 267 µM 0.686211866180601 0.223458312041145 no 746 0.246289758038991 1216 882706 SGTC_821 1114-0266 29.2 µM 0.683904721967776 0.224231955260791 no 747 0.24701766605105 1217 3123235 SGTC_2546 rhodinyl acetate 100 µM 0.682032677603481 0.22486081471571 no 748 0.247609144129671 1201 6708682 SGTC_3327 9140648 26.9345 µM 0.68083470547482 0.225263763068259 no 749 0.247988043634173 1209 8029710 SGTC_1653 st012112 65 µM 0.680482453014056 0.225382324006454 no 750 0.248099514308955 1224 720429 SGTC_1115 galangin 695.678 nM 0.679661455154769 0.225658792100743 no 751 0.248359423686495 1265 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2124 5246320 200 µM 0.679284984647647 0.225785631337223 no 752 0.248478654264089 1219 579342 SGTC_662 k832-1615 104 µM 0.678926684328427 0.225906386176133 no 753 0.248592158551634 1201 5878478 SGTC_3342 9147791 14.508 µM 0.676693811059287 0.226659734389472 no 754 0.249300122013732 1196 1838168 SGTC_2380 9035439 200 µM 0.676690771902235 0.226660760734758 no 755 0.249301086350626 1291 6462575 SGTC_2787 5284540 71.43 µM 0.674490759476595 0.227404408662145 no 756 0.249999679274407 1234 736958 SGTC_261 5-fluorouridine 15.376 µM 0.673140554856085 0.227861484418873 no 757 0.250428937681917 1254 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2447 5741742 33.78 µM 0.672670922439725 0.2280205870347 no 758 0.250578335204642 1263 1776504 SGTC_1243 0416-0003 5.65 µM 0.67139264696767 0.22845395902736 no 759 0.25098521395512 1230 2141977 SGTC_2136 5328288 199.296 µM 0.67102312798495 0.228579322713466 no 760 0.251102898013551 1208 262395 SGTC_263 alizarin 107.927 µM 0.670907494096791 0.228618560813903 no 761 0.251139730981254 1234 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_2762 leflunomide 42.06 µM 0.667303309262024 0.229843465319126 no 762 0.252289206506129 1237 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2481 5478948 45.16 µM 0.667118297886623 0.229906441570467 no 763 0.252348286576551 1244 77792 SGTC_429 1112-0049 25.5 µM 0.666922203410224 0.229973200955361 no 764 0.252410913797564 1210 2836170 SGTC_2484 5809818 12.04 µM 0.663708913276822 0.231068693796306 no 765 0.25343831674392 1256 2870548 SGTC_2299 7976368 114.88 µM 0.663413133224101 0.23116967896481 no 766 0.253532998464963 1239 2979718 SGTC_1019 4262-0212 3.4 µM 0.662126296540928 0.231609317005295 no 767 0.253945142085798 1298 4677213 SGTC_607 4491-0986 66.8 µM 0.662010868495137 0.231648774887761 no 768 0.253982128158125 1267 698981 YDR232W HEM1 SGTC_1375 2910-0797 186 µM 0.661076799614315 0.231968214444737 no 769 0.254281531462289 1243 742508 SGTC_246 cycloheximide 667 µM 0.660883120703515 0.232034480833739 no 770 0.254343635803977 1147 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_248 streptozotocin 5.23457 mM 0.660587647956215 0.232135595837819 no 771 0.254438396284248 1283 5300 DNA alkylating agent. SGTC_2536 dehydroabietamide 32.04 µM 0.65978761351875 0.232409502143215 no 772 0.254695066581555 1285 3983547 SGTC_1005 4092-0690 4.4 µM 0.659389438921568 0.232545891409726 no 773 0.254822861086866 1243 1529343 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.658964483667068 0.232691503104958 no 774 0.254959287887165 1277 676296 Flavone; oxidizing agent. SGTC_2690 usnic acid 100 µM 0.658890763976969 0.232716768448715 no 775 0.254982958601192 1317 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3337 9144342 33.5465 µM 0.658607942505345 0.232813711671356 no 776 0.255073780639244 1259 17682949 SGTC_2201 6605497 169.863 µM 0.657352277725203 0.23324438898469 no 777 0.255477214650517 1251 670741 SGTC_1488 4013-0813 75.9 µM 0.656712036768884 0.233464153718211 no 778 0.255683046676643 1242 2910057 SGTC_1731 st035964 63 µM 0.656503088406468 0.233535900756004 no 779 0.255750240536474 1267 6739575 SGTC_1955 wogonin 32.4 µM 0.656473577576069 0.23354603493718 no 780 0.255759731406904 1318 5281703 A flavanone. SGTC_642 0335-0876 158 µM 0.656119430076204 0.233667670156061 no 781 0.255873641833279 1270 6812350 SGTC_3000 9075062 71.4286 µM 0.656067005209541 0.233685678942994 no 782 0.255890506375848 1246 17057871 SGTC_2503 beta-caryophyllene alcohol 24.72 µM 0.655663546810778 0.233824299151745 no 783 0.256020314217297 1235 61125 An anti-inflammatory. SGTC_2383 9036125 200 µM 0.655276343797935 0.233957377177395 no 784 0.256144924381179 1206 79580 SGTC_119 0121-0043 24.815 µM 0.655073395124274 0.234027145479785 no 785 0.256210250211307 1313 1092378 SGTC_2971 9092186 9.93 µM 0.654845907750552 0.234105363224527 no 786 0.256283484968241 1213 25236400 SGTC_1695 st026914 34.495 µM 0.654599079314488 0.2341902474446 no 787 0.256362958513166 1236 3289191 SGTC_488 nitrendipine 139 µM 0.653044836080936 0.234725142489488 no 788 0.256863686930338 1299 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1350 1495-0454 146 µM 0.651675216035442 0.235197058534889 no 789 0.257305357047162 1292 1069057 SGTC_911 3456-4043 236 µM 0.651034624505276 0.235417960344972 no 790 0.257512068083077 1334 914281 SGTC_2210 7115885 190.385 µM 0.65074612846561 0.235517482805155 no 791 0.257605190383005 1273 2927039 SGTC_2343 7990716 14.84 µM 0.650518554312428 0.235596005421518 no 792 0.257678660325509 1244 6456862 SGTC_1949 st076024 69.1 µM 0.649566274238053 0.23592473854114 no 793 0.257986211982113 1246 2921930 SGTC_1294 1000-1494 117 µM 0.648929547293851 0.236144681675453 no 794 0.258191957681427 1244 712797 YDL207W GLE1 SGTC_2946 9065502 71.43 µM 0.648640086959948 0.236244706630146 no 795 0.258285519171414 1107 16489101 SGTC_3355 9151058 44.0485 µM 0.647883417341052 0.236506289059933 no 796 0.258530178446027 1265 17015728 SGTC_2567 aureobasidin a 60 nM 0.641348273517211 0.238772123517971 no 797 0.260648216020808 1354 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_722 3534-0461 190 µM 0.640957578662801 0.238907958582711 no 798 0.260775122414547 1247 658262 SGTC_1784 st039334 36.3 µM 0.640681008289991 0.239004140890533 no 799 0.260864977847913 1342 3496984 SGTC_660 4031-1742 102 µM 0.640395743332667 0.239103369070993 no 800 0.260957674761981 1212 6738706 SGTC_2915 7971052 15.16 µM 0.63944859541376 0.239432991812727 no 801 0.261265572137674 1157 5741558 SGTC_2552 juarezic acid 87.02 µM 0.63857039154167 0.239738842496719 no 802 0.261551223955406 1326 1549512 SGTC_626 0214-0009 33 µM 0.63714570001154 0.240235470701127 no 803 0.26201497161747 1344 3437874 SGTC_2914 7968218 45.32 µM 0.637029534362055 0.240275989180691 no 804 0.262052802975481 1267 2977111 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.632036851588272 0.242020946989276 no 805 0.263681398586609 1311 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2198 6589944 200 µM 0.63154385451112 0.242193623017536 no 806 0.263842492125138 1266 5290268 SGTC_878 0828-0289 13.7 µM 0.6311306474555 0.242338403406525 no 807 0.263977551826492 1308 745350 YLR208W SEC13 SGTC_3201 9113999 49.47 µM 0.631127948909351 0.242339349083125 no 808 0.263978433981525 1321 16649224 SGTC_3128 9127691 49.47 µM 0.6309579472583 0.242398928372078 no 809 0.264034010568443 1297 41316314 SGTC_2848 9016370 25.97 µM 0.630645834205914 0.242508333105967 no 810 0.264136061439136 1318 7894410 SGTC_553 k007-0256 45.7 µM 0.62939789664556 0.242946038771744 no 811 0.264544297328735 1339 6287000 SGTC_286 k060-0067 22.9 µM 0.629211671934631 0.243011392458986 no 812 0.264605244246086 1263 5985051 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.628443161028566 0.24328119418954 no 813 0.264856835118574 1261 4620898 SGTC_2873 9040596 71.43 µM 0.628223478902236 0.243358347912053 no 814 0.264928775785318 1288 6463863 SGTC_3180 9109287 49.47 µM 0.627884807441442 0.24347731732566 no 815 0.265039702078546 1282 18891271 SGTC_1556 plumbagin 1.48 µM 0.62602980120978 0.244129505845729 no 816 0.265647697276283 1243 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2620 irigenin 100 µM 0.625944481774669 0.244159525347439 no 817 0.265675678502379 1359 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_18 0111-0177 500 nM 0.625319388814774 0.244379523969034 no 818 0.265880728568061 1361 721752 SGTC_3330 9141424 71.43 µM 0.624861751162785 0.244540655164955 no 819 0.266030898880951 1306 27261020 SGTC_888 0916-0002 6.97 µM 0.623445584215062 0.245039640547831 no 820 0.266495875295816 1356 2802138 YIL048W NEO1 SGTC_3028 9087778 49.47 µM 0.621609167183926 0.245687515505575 no 821 0.267099445824933 1256 17217395 SGTC_2514 salinomycin 42.74 µM 0.62140235126284 0.245760536286601 no 822 0.267167462703517 1344 23682228 A polyether potassium ionophore. SGTC_2492 derrusnin 100 µM 0.62124614855812 0.245815694712255 no 823 0.26721883988364 1235 1715307 Part of coumarin class of compounds. SGTC_998 3996-0085 177 µM 0.621141876432413 0.245852519068132 no 824 0.267253139169759 1333 715391 SGTC_2930 9013230 14.89 µM 0.615964301106863 0.247684730284509 no 825 0.268959040615484 1314 2995857 SGTC_1477 0139-0234 16 µM 0.615681487844351 0.247785020262764 no 826 0.269052378808027 1326 620880 SGTC_2706 st078239 82.5 µM 0.615017903287886 0.248020422751304 no 827 0.269271448545959 1310 15434492 SGTC_3211 9128781 49.47 µM 0.612254271694929 0.249002085773955 no 828 0.270184769660894 1325 17194361 SGTC_3296 9122258 64.045 µM 0.611702345909145 0.249198381404312 no 829 0.270367354753431 1339 4730474 SGTC_900 1112-0045 141 µM 0.611477724231858 0.249278292971631 no 830 0.270441680531158 1253 56211 YIL048W NEO1 SGTC_1689 st020265 53.493 µM 0.607033741540538 0.250862084776685 no 831 0.271914260071458 1378 5758320 YPR016C TIF6 SGTC_1809 st050081 57.6 µM 0.606902325064457 0.250909001272781 no 832 0.271957867514883 1379 5036894 SGTC_2988 9073640 71.4286 µM 0.606219303769226 0.251152918881746 no 833 0.27218456795111 1371 9102229 SGTC_2206 7254556 146.969 µM 0.606119216806762 0.251188672037409 no 834 0.272217795533079 1316 4398905 SGTC_2551 apiole 73.87 µM 0.605568945164633 0.25138528864582 no 835 0.272400514630114 1255 10659 A possible DNA adduct former. SGTC_2502 avocadyne acetate 18.59 µM 0.604664048369117 0.251708792549786 no 836 0.272701120305379 1296 3952079 SGTC_606 k015-0008 38.6 µM 0.604360333718065 0.251817420902934 no 837 0.272802050847909 1416 1970475 SGTC_445 e6 berbamine 66 µM 0.604129732769562 0.251899915509725 no 838 0.27287869659786 1361 6610268 A calcium/calmodulin antagonist. SGTC_1464 k208-0027 110 µM 0.604024643312048 0.251937514680416 no 839 0.272913629139001 1423 X1464 SGTC_373 0844-0104 25.9 µM 0.603450721022098 0.25214290628831 no 840 0.2731044444243 1336 5375804 SGTC_1546 5-methoxyflavanone 78.7 µM 0.603333491294944 0.252184870566981 no 841 0.273143428604938 1387 147795 SGTC_1004 4084-0029 199 µM 0.603245584117212 0.252216340780841 no 842 0.273172663522235 1352 716894 YLR208W SEC13 SGTC_3262 9137218 49.47 µM 0.602597492975501 0.252448417213365 no 843 0.273388244283607 1221 17650664 SGTC_413 propylparaben 100 µM 0.600546715639189 0.253183525569929 no 844 0.274070968534166 1299 7175 A pharmaceutical preservative. SGTC_2445 5742597 35.57 µM 0.598653823692206 0.253863037100654 no 845 0.274701877888831 1310 1774255 SGTC_1646 st011709 75.6 µM 0.598146367126993 0.254045366751585 no 846 0.274871137084854 1328 5757843 SGTC_816 0325-0417 81.3 µM 0.598133085616978 0.254050139733807 no 847 0.274875567745683 1319 68101 SGTC_397 arbidol 50 µM 0.597948927035332 0.254116325734289 no 848 0.274937005969947 1409 131410 A RNA synthesis inhibitor. SGTC_3312 9133330 71.43 µM 0.596699406392676 0.254565638179569 no 849 0.275354044500006 1392 17617324 SGTC_1285 0929-0069 65.5 µM 0.595130740744357 0.255130299920642 no 850 0.275878040811237 1353 1206237 SGTC_1797 st048695 56.8 µM 0.594897539668881 0.255214299596046 no 851 0.275955980991916 1322 592262 YIL048W NEO1 SGTC_54 0159-0055 9 µM 0.594862222048867 0.255227022361658 no 852 0.275967785746963 1439 3319099 SGTC_3029 9088683 49.47 µM 0.594630084196986 0.255310655600204 no 853 0.276045382947918 1338 25236615 SGTC_2694 st077685 81.9 µM 0.594021931452292 0.25552982514443 no 854 0.276248722210899 1305 2838096 SGTC_2597 laccaic acid a 100 µM 0.593022276946673 0.255890299768277 no 855 0.276583121889686 1343 5491415 A textile dye. SGTC_2386 9075165 157.42 µM 0.591370323001949 0.256486574163797 no 856 0.277136160179508 1315 16452277 SGTC_918 glabranin 770.725 nM 0.589488781106244 0.257166599254877 no 857 0.277766717913444 1415 124049 Also referred to as licorice root. SGTC_2278 7948257 134.34 µM 0.588865853637811 0.257391943492453 no 858 0.277975632729361 1326 1247028 SGTC_2242 6630449 61.2675 µM 0.588491304737497 0.257527486069065 no 859 0.278101284279082 1371 691249 YDR170C SEC7 SGTC_1125 tnp00248 1.32998 µM 0.587275298572123 0.25796779247445 no 860 0.278509414042331 1451 24207736 SGTC_327 1273-0057 3.96 µM 0.586928944427568 0.258093276043519 no 861 0.278625714710388 1309 3108138 SGTC_2953 9074162 66.49 µM 0.58649120686515 0.258251912952029 no 862 0.278772734420967 1385 16451992 SGTC_3043 9092303 49.47 µM 0.585984485777101 0.258435612712347 no 863 0.278942970263318 1300 25236084 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.585277186181087 0.258692140614234 no 864 0.279180676128301 1329 688662 SGTC_1569 carminic acid 40.6 µM 0.584841742027761 0.258850135789736 no 865 0.279327067069951 1373 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2874 9043904 71.43 µM 0.583222327013271 0.259438157012264 no 866 0.279871821413339 1338 4463428 SGTC_2781 5567276 71.43 µM 0.580113359201321 0.260568976281723 no 867 0.280919087706017 1402 2853274 SGTC_1777 st045864 34.765 µM 0.579519292760344 0.260785343401858 no 868 0.281119416329936 1356 4691462 SGTC_2456 5770359 74.46 µM 0.579515537888752 0.260786711271345 no 869 0.281120682751602 1424 3118787 SGTC_1971 st069429 63.5 µM 0.578301897045249 0.26122902419166 no 870 0.28153015693484 1369 1246522 YGL099W LSG1 SGTC_3177 9107506 49.47 µM 0.577753308428726 0.261429084421687 no 871 0.281715341380492 1332 8897194 SGTC_813 k007-0158 173 µM 0.577558240286706 0.261500241161292 no 872 0.281781203753849 1410 6523916 SGTC_1720 st037298 9.481 µM 0.577155522247734 0.261647175647639 no 873 0.281917200048484 1376 597396 SGTC_2234 tolnaftate 200 µM 0.577067519879827 0.26167928956558 no 874 0.281946922310708 1355 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1366 1683-0113 21.9 µM 0.57637474639213 0.261932167819351 no 875 0.282180955024689 1366 708623 SGTC_1363 1636-0063 10.4 µM 0.576302337503597 0.261958605959789 no 876 0.28220542158918 1396 6072185 SGTC_2394 5221648 200 µM 0.576185828765416 0.26200114883515 no 877 0.282244791392954 1500 788586 SGTC_718 1130-0073 349 µM 0.574396502609641 0.262654961437497 no 878 0.282849759531786 1447 6740020 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.573909953437133 0.262832888806271 no 879 0.283014368614311 1423 688788 SGTC_2643 anethole 100 µM 0.572943498777741 0.263186496724231 no 880 0.283341475413614 1368 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_2515 chrysin 20.77 µM 0.572649107197759 0.263294257438016 no 881 0.283441151365972 1435 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_150 3970-0969 77.2 µM 0.572005062196836 0.263530085758114 no 882 0.283659272574371 1429 6615640 SGTC_752 1896-0090 130 µM 0.570521993243575 0.264073546956709 no 883 0.284161854786539 1385 772567 SGTC_1635 st007035 42.4 µM 0.569435369081652 0.264472095625872 no 884 0.284530359924789 1427 3716403 SGTC_307 1501-1223 22.3 µM 0.567608315033922 0.265142906232328 no 885 0.285150479900748 1368 2830329 SGTC_856 0433-0016 11.3 µM 0.567235009450328 0.265280073192673 no 886 0.285277262668869 1389 3911780 SGTC_749 1000-0129 128 µM 0.56644815364541 0.265569312498452 no 887 0.285544584093098 1480 708470 SGTC_2955 9076254 12.21 µM 0.565863402186263 0.265784364088178 no 888 0.285743321059886 1350 16459619 SGTC_2401 5128683 200 µM 0.56367104552362 0.266591422997631 no 889 0.286489013075851 1307 708373 SGTC_2231 micatex 6.853 µM 0.563080067461283 0.266809188001424 no 890 0.286690181873551 1408 20737 An antifungal of unknown mechanism. SGTC_2508 celastrol 40.54 µM 0.563030928527905 0.26682729887951 no 891 0.286706911770928 1340 122724 Celastrol is a natural product and antioxidant. SGTC_1381 2324-0066 62.1 µM 0.562014383868955 0.267202100687148 no 892 0.287053109517656 1407 10885928 SGTC_2754 granisetron 64.02 µM 0.561565182676318 0.267367806570091 no 893 0.287206153976312 1461 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_3339 9145883 14.936 µM 0.561008537262294 0.267573219462733 no 894 0.287395858633321 1373 2030670 SGTC_521 r062-0005 13.8 µM 0.56070434191314 0.267685507023023 no 895 0.287499553393175 1387 2832033 SGTC_3152 9099253 49.47 µM 0.559781277240801 0.268026382979474 no 896 0.287814317892864 1388 25236131 SGTC_273 hydroxyurea 18.1 mM 0.558332381813558 0.268561881866504 no 897 0.288308718388253 1423 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_3333 9141820 12.094 µM 0.556322341802639 0.269305664233129 no 898 0.288995258301293 1399 1939433 SGTC_2925 9010536 32.5 µM 0.556303318362643 0.269312708476842 no 899 0.289001759531276 1481 2994177 SGTC_3145 9085516 49.47 µM 0.555959854624405 0.269439906533532 no 900 0.289119149543991 1387 25236195 SGTC_2545 solidagenone 89.61 µM 0.554467454799003 0.269992950045423 no 901 0.28962948640822 1314 6708572 An anti ulcer agent SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.55292715200248 0.270564340202278 no 902 0.29015664705967 1422 1609 A potent and irreversible inhibitor of serine proteases. SGTC_597 k018-0003 82.8 µM 0.552348825085935 0.270779032015075 no 903 0.29035469247847 1507 6786234 SGTC_254 nsc-64875 3.808 µM 0.551877740159173 0.27095397530317 no 904 0.290516060129964 1529 56993 SGTC_415 dibenzyl ketone 100 µM 0.549890907598249 0.271692430376973 no 905 0.291197100479497 1505 7593 SGTC_1783 st039459 87.517 µM 0.549273570722616 0.271922082610429 no 906 0.29140886099695 1533 729761 SGTC_3182 9108849 49.47 µM 0.548767573829536 0.272110387826054 no 907 0.29158248293996 1410 17133045 SGTC_2142 5622915 118.518 µM 0.548639723664456 0.272157977136311 no 908 0.291626359604187 1390 5322196 SGTC_562 3772-2733 112 µM 0.547903966910978 0.27243192620432 no 909 0.291878922423963 1411 2876874 YIL048W NEO1 SGTC_2105 5350118 200 µM 0.544988338265957 0.273518865898302 no 910 0.292880769101715 1398 2133313 SGTC_2306 7482397 179.52 µM 0.543591504514249 0.274040361754759 no 911 0.29336130358858 1516 891448 SGTC_1640 st009078 66.4 µM 0.542924740920274 0.274289465326432 no 912 0.293590810308796 1471 690618 SGTC_260 nsc-65238 3.989 µM 0.542079616768475 0.274605365169902 no 913 0.293881829926747 1449 3246252 SGTC_847 0342-0274 5.54 µM 0.541260674653153 0.274911649512807 no 914 0.2941639609481 1466 18097 SGTC_579 4491-1009 110 µM 0.540675698610113 0.275130533571601 no 915 0.294365565690869 1509 1271041 SGTC_2340 7987427 183.45 µM 0.539744999139908 0.275478955871284 no 916 0.29468645115589 1457 2239331 SGTC_1859 st055998 20 µM 0.539444829212434 0.275591375577905 no 917 0.294789977785201 1551 676301 SGTC_2738 aclarubicin 5.55 µM 0.539165718772359 0.275695928317223 no 918 0.294886256178143 1416 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_2116 5511452 16.8835 µM 0.538783068569452 0.275839297979478 no 919 0.295018273881175 1444 870744 SGTC_2487 5918373 44.05 µM 0.537224251842606 0.276423726740329 no 920 0.295556360597351 1476 2876279 SGTC_1039 k821-0043 94 µM 0.537065535866364 0.276483266294329 no 921 0.295611172942195 1498 15992768 SGTC_2797 7859098 81.82 µM 0.536984568312236 0.276513642294164 no 922 0.295639136775887 1427 972681 SGTC_3124 9127567 49.47 µM 0.536818928528376 0.276575789246707 no 923 0.295696347718016 1513 17592030 SGTC_3190 9110366 49.47 µM 0.536691227960801 0.276623706329516 no 924 0.295740458165859 1443 17123768 SGTC_3170 9103054 49.47 µM 0.536349246363754 0.276752048115492 no 925 0.295858600652119 1367 16432970 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 0.536267023912941 0.276782909611309 no 926 0.295887008818365 1434 756377 SGTC_1737 st035557 69.7 µM 0.53610614945695 0.276843297342291 no 927 0.295942595171422 1392 5716916 SGTC_989 1501-0895 10.3 µM 0.535166636191869 0.277196092936194 no 928 0.296267317422853 1451 2830112 SGTC_1018 4259-0013 28.1 µM 0.535144570243238 0.277204381539125 no 929 0.296274945999961 1452 6801262 SGTC_2728 chlorpromazine 9.18 µM 0.53442193206939 0.277475892137566 no 930 0.296524824183729 1444 2726 A thorazine and dopamine antagonist. SGTC_2070 5230947 200 µM 0.532317467492455 0.278267324088419 no 931 0.297253068122245 1499 2835538 SGTC_674 0498-0004 451 µM 0.531804857289131 0.27846026941029 no 932 0.297430579132652 1388 4231473 SGTC_3132 9126706 49.47 µM 0.531411640626872 0.278608319438253 no 933 0.297566778338158 1449 850858 SGTC_538 2922-0838 53.3 µM 0.531063515460176 0.278739424048352 no 934 0.297687382871143 1555 777039 SGTC_1871 st057448 67.3 µM 0.531039281236731 0.278748551821667 no 935 0.29769577940932 1511 691747 SGTC_308 4092-1169 104 µM 0.528820030892867 0.279585044325619 no 936 0.298465150437031 1460 2268590 YDL196W YDL196W SGTC_1431 4049-0260 9.09 µM 0.527256579024555 0.280175080254975 no 937 0.299007711457621 1441 3854841 SGTC_3150 9097574 49.47 µM 0.527029684908943 0.28026075863262 no 938 0.299086487189792 1511 17217476 SGTC_740 k014-0057 261 µM 0.525732115034075 0.280750982762947 no 939 0.299537173456049 1535 4012779 SGTC_2021 4019055 173 µM 0.525168804601531 0.280963931429799 no 940 0.299732924414371 1438 44827708 YER133W GLC7 SGTC_457 grayanotoxin iii 135 µM 0.524934898063421 0.281052378224794 no 941 0.299814224199014 1409 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_3104 9120930 49.47 µM 0.524614225803296 0.281173655494697 no 942 0.299925697699442 1441 17014836 SGTC_667 1498-1044 59 µM 0.523658186665339 0.281535376502132 no 943 0.300258151501522 1493 6739982 SGTC_1922 5578187 25 µM 0.523147093963672 0.28172884238187 no 944 0.300435947582832 1536 1350412 SGTC_2398 5228213 48.84 µM 0.520051202979418 0.28290210973133 no 945 0.301513943929565 1542 80771 YMR134W ERG29 SGTC_2465 5809242 33.21 µM 0.517580695983889 0.283840051837853 no 946 0.302375426613726 1506 2731748 SGTC_2010 4012422 159 µM 0.515613968866116 0.284587793685137 no 947 0.303062026026193 1506 952393 SGTC_298 1391-0729 10 µM 0.515438200868751 0.284654665742926 no 948 0.303123421911749 1437 3237558 SGTC_783 0848-0141 92.7 µM 0.514008195618867 0.285198998979997 no 949 0.303623130354204 1444 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3166 9102297 49.47 µM 0.512773541534722 0.285669370215033 no 950 0.304054869874482 1399 25237072 SGTC_2887 9044784 58.44 µM 0.512564772406865 0.285748942314904 no 951 0.304127900262094 1434 6465546 SGTC_1504 k297-0033 30 µM 0.51061668087416 0.286491962759398 no 952 0.304809746575408 1379 4388117 SGTC_2158 5657123 3.6195 µM 0.509359384321467 0.286971993727439 no 953 0.305250170013361 1466 2858827 SGTC_69 0096-0274 206.684 µM 0.508530453847991 0.28728868444248 no 954 0.305540693744588 1553 6741392 SGTC_1213 1315-0166 115 µM 0.508031745464398 0.28747929431608 no 955 0.305715540191807 1425 768401 SGTC_139 0099-0334 718.624 µM 0.505573656451524 0.288419666075811 no 956 0.306577989430823 1489 97690 SGTC_2372 9071633 200 µM 0.504525660871202 0.288821029896378 no 957 0.306946017239168 1508 21321366 SGTC_1892 st058411 7.36 µM 0.504341215500346 0.288891696419406 no 958 0.307010809634837 1546 3934738 SGTC_588 3970-1144 52.9 µM 0.504193187489215 0.288948416250779 no 959 0.307062813616241 1486 1888707 SGTC_764 1951-2361 146 µM 0.503665804721298 0.289150535863026 no 960 0.307248120927595 1424 5438930 SGTC_1224 0823-0416 294 µM 0.502844965608811 0.289465254901086 no 961 0.307536638380492 1540 3598164 SGTC_2954 9074818 52.69 µM 0.501243780079611 0.290079630211703 no 962 0.308099783130751 1526 16648742 SGTC_1152 3909-8331 15.9 µM 0.500667728608425 0.290300810709094 no 963 0.308302493891463 1464 16001939 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.499490291230929 0.290753144646999 no 964 0.308717012371405 1504 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2759 disulfiram 3.38 µM 0.498818969321548 0.29101119257794 no 965 0.308953461373304 1426 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1647 st011722 22.4 µM 0.498780159080935 0.291026114030807 no 966 0.308967133307178 1490 2854783 SGTC_481 bay k-8644 50 µM 0.498127212014722 0.291277207503713 no 967 0.309197190853415 1438 2303 A calcium channel antagonist. SGTC_275 trichlorophene 5.69 µM 0.496650851710909 0.291845320399123 no 968 0.309717643318075 1530 62616 SGTC_1384 3089-0840 101 µM 0.496225889041713 0.292008944376074 no 969 0.309867523660894 1567 1069836 SGTC_1630 st005209 31.3 µM 0.495695970710999 0.292213039393752 no 970 0.310054465161639 1516 3367314 SGTC_3038 9091290 49.47 µM 0.495248025341648 0.292385614737323 no 971 0.310212527024207 1533 25236843 SGTC_162 k030-0015 37.8 µM 0.492455576370762 0.293462500035898 no 972 0.311198659475648 1624 1809920 YMR134W ERG29 SGTC_2839 9003951 25.97 µM 0.49118500754356 0.293953091990984 no 973 0.311647800889306 1514 2990634 SGTC_21 0849-0113 22.993 µM 0.490648208516911 0.294160474693741 no 974 0.311837641660047 1472 1560156 SGTC_350 k064-0020 19.8 µM 0.49031557183126 0.294289016843894 no 975 0.311955304833598 1578 2790705 SGTC_34 0469-0683 81.75 µM 0.490215903527482 0.294327537123318 no 976 0.311990564119703 1552 3690923 SGTC_174 3553-0389 74.3 µM 0.490169143183351 0.294345610085618 no 977 0.312007106946932 1514 738071 SGTC_808 0711-0032 135 µM 0.489228607128041 0.294709237830784 no 978 0.312339929318497 1604 4252555 SGTC_3120 9124077 49.47 µM 0.48896967498433 0.294809381897283 no 979 0.312431583125669 1502 18774327 YGL155W CDC43 SGTC_2544 sphondin 68.51 µM 0.487489365470956 0.295382204357341 no 980 0.312955788655854 1553 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_2159 5658611 73.75 µM 0.486882293162742 0.295617265799892 no 981 0.313170873881259 1507 793844 SGTC_2702 st077768 96.8 µM 0.486527900184291 0.295754528277586 no 982 0.313296464422584 1454 6484119 SGTC_2294 7971431 200 µM 0.486486449941645 0.295770584579989 no 983 0.313311155063029 1505 5741572 SGTC_3081 9117243 49.47 µM 0.486480506318093 0.295772886954398 no 984 0.313313261604211 1594 45595589 SGTC_222 nsc-310342 10.666 µM 0.485541368815974 0.296136782925856 no 985 0.313646187531988 1555 432556 SGTC_514 4466-0038 2.65 nM 0.485326200989625 0.296220184835195 no 986 0.313722486300406 1536 5722064 SGTC_3183 9108214 49.47 µM 0.484753606430504 0.296442182565642 no 987 0.313925567824067 1468 4974831 SGTC_1516 st013856 110 µM 0.484189543476409 0.296660947079473 no 988 0.314125678575248 1483 5281404 A mutagen and neurotoxin. SGTC_423 5-fluorouracil 457 µM 0.483636377534315 0.296875557107212 no 989 0.314321976516406 1426 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_701 4424-0219 185 µM 0.482764124229073 0.297214106704313 no 990 0.314631613338997 1603 2911779 SGTC_1119 parthenolide 318.541 nM 0.482492565045305 0.297319543578001 no 991 0.314728039400115 1615 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2876 9059903 25.97 µM 0.482455398769949 0.297333975264089 no 992 0.314741237497329 1488 6916095 SGTC_2228 7354201 200 µM 0.482193138046853 0.297435820349383 no 993 0.314834375495992 1582 753451 SGTC_627 1391-0720 175 µM 0.480577943480965 0.298063408250425 no 994 0.315408247318983 1503 997839 SGTC_1216 1165-0504 9.65 µM 0.478450946405318 0.298890777493072 no 995 0.316164640037702 1577 6304004 SGTC_775 4577-0580 57.3 µM 0.477935111028655 0.299091586635468 no 996 0.316348195129275 1574 2006902 SGTC_1321 1326-2144 215 µM 0.475940590594712 0.29986860749803 no 997 0.317058351650674 1579 3513030 SGTC_2063 5246145 200 µM 0.475428781856571 0.300068144050755 no 998 0.317240691909373 1562 711240 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.475034064063593 0.300222071896954 no 999 0.317381346907537 1603 16725076 SGTC_2339 9000433 200 µM 0.47439823281629 0.300470101641257 no 1000 0.317607976500724 1470 2988954 SGTC_1651 st011928 86.1 µM 0.473638334970274 0.300766649545258 no 1001 0.317878916879598 1508 720198 SGTC_1198 1612-1005 86.7 µM 0.473449247057319 0.30084046106147 no 1002 0.317946351035889 1599 6998509 SGTC_1998 st075797 76.8 µM 0.471617332111614 0.301555981849362 no 1003 0.318599976577049 1543 24208315 SGTC_2655 perillic acid 100 µM 0.471208509507221 0.301715766774038 no 1004 0.318745921268213 1494 5702197 An apoptosis inducer. SGTC_2764 methyldopa 94.69 µM 0.471199582601297 0.301719256205842 no 1005 0.318749108378672 1617 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1621 st003705 32.4 µM 0.468806650543644 0.302655281197305 no 1006 0.319603922900186 1620 24207032 SGTC_2277 7947813 106.88 µM 0.467870347843932 0.303021881395778 no 1007 0.319938654757268 1623 1246798 SGTC_1191 1487-1166 10.6 µM 0.46528545899289 0.304034999290911 no 1008 0.32086352325924 1610 3955771 SGTC_2789 5281112 71.43 µM 0.464198428623402 0.304461499041218 no 1009 0.321252793464118 1481 765948 SGTC_745 0469-0705 296 µM 0.463317207629037 0.304807444130697 no 1010 0.321568506669585 1655 3486736 SGTC_1608 st001473 40.5 µM 0.463105206666812 0.304890696414423 no 1011 0.321644479058275 1478 7292267 SGTC_1852 st056254 31.4 µM 0.46144660608611 0.305542373394394 no 1012 0.322239110252658 1583 442583 SGTC_1347 1493-0251 600 nM 0.461273630505275 0.305610372373188 no 1013 0.322301150623747 1644 3986378 SGTC_3346 9158254 43.5805 µM 0.460654714762746 0.305853731204204 no 1014 0.322523174874765 1528 17639500 SGTC_2134 5324836 1.464 µM 0.460301193917974 0.30599277474889 no 1015 0.322650022167034 1586 699272 SGTC_1673 st016611 27.3 µM 0.459833468773255 0.306176779038758 no 1016 0.322817878979748 1621 5226799 SGTC_1770 st043884 66.3 µM 0.459826300744445 0.306179599340562 no 1017 0.322820451716973 1536 670149 SGTC_1205 4161-2785 76 µM 0.458348009201951 0.306761486841575 no 1018 0.323351218766637 1463 3498106 SGTC_2533 agelasine 13.65 µM 0.458098049678017 0.306859924515771 no 1019 0.32344100002891 1693 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_987 1497-1013 404 µM 0.457751382274405 0.306996470203659 no 1020 0.32356553415324 1563 1676435 SGTC_1343 1487-0095 224 µM 0.457253374944465 0.307192672662306 no 1021 0.32374446905119 1591 4560101 YGL055W OLE1 SGTC_2737 bleomycin 30.5 nM 0.456364035395618 0.307543187550268 no 1022 0.324064111636753 1553 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_2429 5902844 64.44 µM 0.455731828666308 0.307792465752763 no 1023 0.32429141557103 1652 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2902 5787006 60.46 µM 0.455358913462274 0.307939547301119 no 1024 0.324425524413625 1520 591003 SGTC_2125 5246583 200 µM 0.454772122300913 0.308171046178367 no 1025 0.324636594053612 1681 835267 SGTC_2441 5730946 39.09 µM 0.454444654828836 0.308300270736115 no 1026 0.324754409077227 1626 1774275 SGTC_2736 butenafine 14.65 µM 0.453978318058775 0.308484336625316 no 1027 0.324922216239757 1611 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_20 0481-0013 4.944 µM 0.453790619538121 0.308558435936374 no 1028 0.324989767922302 1513 182045 SGTC_189 3970-0742 2.116 µM 0.453159944441735 0.308807469908559 no 1029 0.325216786615995 1596 2891807 SGTC_882 0843-0131 351 µM 0.453051495868328 0.308850301739465 no 1030 0.325255830457363 1553 5425421 SGTC_1763 st044482 94.5 µM 0.450714534576804 0.309773916885624 no 1031 0.326097652740716 1603 88505 SGTC_2989 9073649 71.4286 µM 0.447072177932411 0.311215846937973 no 1032 0.327411473240381 1620 21367202 SGTC_1617 st002906 78 µM 0.446072729076507 0.311612015400999 no 1033 0.327772355566336 1549 5150859 SGTC_2601 securinine 100 µM 0.446029331335659 0.311629222643739 no 1034 0.327788029328138 1524 442872 A GABA receptor antagonist. SGTC_3153 9100258 49.47 µM 0.443980356312196 0.312442110710222 no 1035 0.328528393085584 1515 25236848 SGTC_2909 7941780 10.49 µM 0.443282022637415 0.312719368954244 no 1036 0.328780878672855 1652 1243215 SGTC_853 0419-0306 21 µM 0.439093502475253 0.31438455019064 no 1037 0.330296893466438 1512 762713 SGTC_3252 9135871 49.47 µM 0.43877168523914 0.3145126482809 no 1038 0.330413489394034 1598 17682838 SGTC_76 0433-0009 400.328 µM 0.437586418384718 0.314984631617462 no 1039 0.330843059175917 1575 2841569 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.437373328252832 0.315069517999158 no 1040 0.330920311915274 1633 688751 SGTC_2793 7325131 81.82 µM 0.437171734618823 0.315149833638399 no 1041 0.33099340339404 1630 4176441 SGTC_2224 6650123 117.647 µM 0.436849076823762 0.315278399866677 no 1042 0.331110402315857 1571 2908370 SGTC_3107 9121808 49.47 µM 0.436199110379435 0.315537453419492 no 1043 0.331346136668784 1588 662681 SGTC_417 st075190 100 µM 0.435148592352721 0.315956344301266 no 1044 0.331727287148648 1662 222757 SGTC_2207 7258803 200 µM 0.432874620010591 0.316863893147624 no 1045 0.332552929562156 1624 3666799 SGTC_2828 7998861 71.43 µM 0.431486030348044 0.31741862611856 no 1046 0.333057503993862 1694 2988188 SGTC_3047 9092122 49.47 µM 0.431394237069327 0.317455311437258 no 1047 0.333090869754726 1536 17173831 SGTC_651 3253-0966 34.4 µM 0.43126471663318 0.317507077519667 no 1048 0.333137951134276 1545 781462 SGTC_292 k038-0015 474 µM 0.430814609437947 0.317687001867075 no 1049 0.333301587982163 1602 46368540 SGTC_1185 1319-0113 81.3 µM 0.430051485553346 0.317992148846391 no 1050 0.333579094806775 1625 4672763 SGTC_2297 7971671 152.32 µM 0.429692883274736 0.318135584261323 no 1051 0.333709530499636 1684 909016 SGTC_193 1273-0060 1.558 µM 0.429137220800141 0.318357894612218 no 1052 0.333911683302787 1538 2847393 YHR072W ERG7 SGTC_2280 7785178 200 µM 0.428843982931037 0.318475240078614 no 1053 0.334018384151793 1595 2954328 SGTC_385 1494-0393 12.4 µM 0.428080419938373 0.318780881731482 no 1054 0.334296285765721 1609 3090647 SGTC_2832 7992762 51.95 µM 0.427916727291789 0.318846421251401 no 1055 0.334355874148763 1423 2985177 SGTC_3086 9117350 49.47 µM 0.42784259668284 0.31887610364543 no 1056 0.334382860992743 1529 2679265 SGTC_2338 7999974 200 µM 0.425448801224138 0.319835219015309 no 1057 0.335254768578457 1739 315925 SGTC_751 0833-0568 350 µM 0.423455036916261 0.320634975817233 no 1058 0.335981648546522 1636 6954252 SGTC_2049 5262831 67.185 µM 0.422740471258092 0.320921811929344 no 1059 0.336242312092952 1599 763417 SGTC_1266 0828-0227 32.9 µM 0.422066796037816 0.321192331999717 no 1060 0.33648813150332 1644 3913820 SGTC_1187 1391-0724 117 µM 0.420843620851723 0.321683751031801 no 1061 0.336934638262131 1624 6997986 SGTC_774 k060-0086 136 µM 0.420724240891858 0.321731729482906 no 1062 0.336978228937274 1763 5911235 SGTC_2621 lithochol-11-enic acid 100 µM 0.420501130340106 0.321821404920105 no 1063 0.33705970191029 1741 6708711 SGTC_959 1222-0044 107 µM 0.42008293315 0.321989520023509 no 1064 0.337212434991831 1713 6083612 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.41901995328808 0.322417001453885 no 1065 0.337600774956986 1591 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_683 panaxydol 45 µM 0.41860621501819 0.32258345143143 no 1066 0.337751973350194 1686 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_1420 4'-methoxyflavone 42 µM 0.417264963171297 0.323123291382898 no 1067 0.338242306470536 1695 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3139 9095020 49.47 µM 0.417206375735086 0.323146880722619 no 1068 0.338263731052211 1508 25236292 SGTC_1572 epiandrosterone 68.9 µM 0.415962741661967 0.323647778710794 no 1069 0.33871863356703 1652 441302 A steroid. SGTC_2037 5169046 200 µM 0.41566068709723 0.323769485387014 no 1070 0.338829156103679 1636 5718022 SGTC_2840 9008771 71.43 µM 0.415481958113142 0.323841509432767 no 1071 0.338894560030954 1748 2992978 SGTC_2164 5685496 200 µM 0.415461517789615 0.32384974687642 no 1072 0.338902040254502 1681 759046 SGTC_1312 1218-2183 165 µM 0.41485285106778 0.324095078886513 no 1073 0.33912481353463 1614 6744073 SGTC_2665 lovastatin 100 µM 0.41481519314985 0.324110259971239 no 1074 0.339138598259279 1596 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_678 1218-2179 85.9 µM 0.414642425751863 0.324179911662468 no 1075 0.339201842726093 1642 6820081 YOR116C RPO31 SGTC_2078 5212016 200 µM 0.413325939014474 0.324710859173381 no 1076 0.339683913944934 1695 1899708 SGTC_2250 alverine citrate 130 µM 0.413135614196745 0.324787647897594 no 1077 0.33975362882677 1577 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_59 0330-0160 1.33 µM 0.412626531482682 0.324993079729606 no 1078 0.339940129821753 1661 4293482 SGTC_2980 9014342 25.29 µM 0.411864856701517 0.325300540243649 no 1079 0.340219240349116 1608 2996599 SGTC_1344 1488-0097 29.1 µM 0.409827929828339 0.326123357801526 no 1080 0.340966088181925 1633 747966 SGTC_107 0358-0022 2.6945 µM 0.40955093387918 0.32623531597123 no 1081 0.341067698148948 1688 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_372 0155-0182 15.9 µM 0.406155386304139 0.327609022347014 no 1082 0.342314216072374 1692 771486 SGTC_324 1315-0088 19.6 µM 0.404451399860532 0.328299270789789 no 1083 0.342940404730931 1651 6787421 SGTC_1836 st055642 81 µM 0.402895392806511 0.328930088442577 no 1084 0.343512590388599 1554 8571 SGTC_3090 9117696 49.47 µM 0.402690893629923 0.329013030326362 no 1085 0.343587816940787 1726 7923821 SGTC_1479 0549-0158 134 µM 0.402418301463989 0.329123602824229 no 1086 0.343688101640964 1628 5440202 SGTC_544 k015-0020 52.4 µM 0.402282227009553 0.329178804768346 no 1087 0.343738166572498 1642 3008304 SGTC_2402 5553605 200 µM 0.401868203219251 0.329346786589062 no 1088 0.343890512330027 1688 6758546 SGTC_717 1532-0246 73.2 µM 0.401492539262288 0.329499234492172 no 1089 0.344028764994605 1611 9561992 SGTC_1453 4237-0541 195 µM 0.397989456232673 0.330922179431748 no 1090 0.345318978936315 1755 739892 SGTC_3025 9087895 49.47 µM 0.397489195172656 0.331125584492022 no 1091 0.345503376344312 1717 17173641 SGTC_390 dec-rvkr-cmk 16.7 µM 0.396986172930871 0.331330162503447 no 1092 0.345688828505289 1665 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_2729 fluphenazine 10.66 µM 0.39345726394228 0.332766774380061 no 1093 0.346990891180651 1567 3372 An atypical antipsychotic. SGTC_1084 voriconazole 435 nM 0.393144510684474 0.332894214532901 no 1094 0.347106375324207 1731 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1979 st071809 45.3 µM 0.389598440912425 0.33434050820813 no 1095 0.34841675259772 1702 4976333 SGTC_2894 9048625 32.47 µM 0.38909625585533 0.334545528063146 no 1096 0.34860247154047 1761 4092861 SGTC_1794 st048918 76.9 µM 0.388885956422677 0.334631398644566 no 1097 0.348680255622556 1755 672303 SGTC_1975 st070967 30.8 µM 0.388465910714677 0.334802939829666 no 1098 0.348835638228967 1750 261391 SGTC_479 n-linoleoylglycine 10 µM 0.388166393813751 0.334925279683279 no 1099 0.348946450508358 1640 6433346 An anti-infammatory. SGTC_884 0851-0618 334 µM 0.388023406799894 0.334983689946642 no 1100 0.348999355963441 1746 9642473 SGTC_2477 5967686 25.23 µM 0.387123437978266 0.335351419215368 no 1101 0.349332413407349 1591 776118 SGTC_2806 7952793 58.44 µM 0.386178703262865 0.335737609714566 no 1102 0.349682162519005 1670 2972490 SGTC_653 0203-0016 55.2 µM 0.385017997318689 0.336212322922789 no 1103 0.350112040776585 1694 295302 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.383405870430031 0.336872094648567 no 1104 0.350709425661756 1762 94937 An inhibitor of serotonin biosynthesis. SGTC_716 1683-5115 658 µM 0.382485713489807 0.337248899197095 no 1105 0.351050561905614 1695 723597 SGTC_1245 0418-0076 17.2 µM 0.382418673690096 0.337276358402604 no 1106 0.351075420737444 1673 6790114 SGTC_1033 k072-0102 21.3 µM 0.380969258298343 0.337870244280166 no 1107 0.351613029896604 1764 5965931 SGTC_2642 cholecalciferol 100 µM 0.380959626591556 0.337874192144046 no 1108 0.351616603430382 1708 9821465 A vitamin D precursor, similar to steriods. SGTC_1427 4048-4900 550 nM 0.380669028833078 0.337993311338391 no 1109 0.351724426509264 1747 24132586 SGTC_455 paf C-16 10 µM 0.380511969617427 0.338057698380493 no 1110 0.351782706557317 1656 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_268 camptothecin 39.6153 µM 0.380049939867116 0.338247136752093 no 1111 0.351954172376303 1659 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1017 4239-0030 168 µM 0.379221224462944 0.33858702372606 no 1112 0.352261795881868 1579 1149593 SGTC_647 0140-0236 81 µM 0.378966902088017 0.338691357165634 no 1113 0.352356221079819 1700 990837 SGTC_2244 6635614 200 µM 0.374574192526821 0.340495373773663 no 1114 0.353988584642659 1654 836499 SGTC_2892 9047358 58.44 µM 0.374301751856586 0.340607381674906 no 1115 0.354089914431453 1642 6466771 SGTC_3194 9111903 49.47 µM 0.373937753183713 0.34075705354256 no 1116 0.354225313826031 1704 17087251 SGTC_1848 st056003 16.4 µM 0.373547479852648 0.340917557086542 no 1117 0.354370507281982 1707 146492 SGTC_2223 6903751 107.57 µM 0.373436235116102 0.340963312796539 no 1118 0.354411897558665 1736 5598863 SGTC_1422 4031-0024 15.5 µM 0.373365571253208 0.34099237853462 no 1119 0.35443819000427 1720 782427 SGTC_2391 6285546 200 µM 0.373131056345177 0.341088846891531 no 1120 0.35452545273597 1629 846083 SGTC_1297 1068-0111 14.1 µM 0.372784289080096 0.341231509602705 no 1121 0.354654498435142 1606 767057 SGTC_589 1227-0070 34.1 µM 0.370902532651671 0.342006073920349 no 1122 0.355355064357309 1699 2841384 SGTC_2046 4110841 106 µM 0.370465099044817 0.342186224785545 no 1123 0.355517988246255 1745 44119630 YMR134W ERG29 SGTC_895 0964-0006 13.7 µM 0.370423658764323 0.342203293244402 no 1124 0.355533424213387 1741 6738897 SGTC_2575 plumbagin 510 nM 0.369882037788158 0.34242640619505 no 1125 0.355735192782181 1608 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_992 3909-8734 162 µM 0.369731359149295 0.342488485869619 no 1126 0.355791331869769 1646 4288319 SGTC_1323 1348-1351 11.2 µM 0.368756197543388 0.342890355760684 no 1127 0.356154728235641 1653 6989654 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.36859810376016 0.342955523910668 no 1128 0.356213654591995 1693 364106 SGTC_2861 9024595 19.48 µM 0.368516534614207 0.342989149516438 no 1129 0.35624405923402 1690 16482810 SGTC_1816 st051957 91.6 µM 0.368236293020391 0.343104684208266 no 1130 0.356348525367676 1676 674121 SGTC_3292 9120825 59.784 µM 0.367930908230951 0.343230601341392 no 1131 0.356462376447956 1823 24824900 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.367019657168225 0.343606434412282 no 1132 0.356802177683295 1691 4213774 SGTC_2958 9077254 16.72 µM 0.365639137523735 0.34417610543804 no 1133 0.357317183422976 1662 16457351 SGTC_2018 5133068 143 µM 0.364960062553256 0.344456455424861 no 1134 0.357570609224946 1662 785362 SGTC_2671 danthron 100 µM 0.363022504407664 0.345256828262212 no 1135 0.358294036682664 1678 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_2812 7970281 58.44 µM 0.362888638458209 0.345312151663351 no 1136 0.358344037133134 1790 2233435 SGTC_1315 1237-0019 3.69 µM 0.36267767822886 0.34539934288326 no 1137 0.358422838101398 1756 825140 SGTC_908 3448-7491 47.7 µM 0.361841052977962 0.345745206231342 no 1138 0.358735406011779 1636 1203031 SGTC_3143 9086658 49.47 µM 0.360231703396363 0.346410878014928 no 1139 0.359336934038791 1669 25236626 SGTC_2393 9031399 185.94 µM 0.359808311351461 0.346586083697552 no 1140 0.359495243673296 1766 1526623 YDL150W RPC53 SGTC_2409 alverine citrate 63.97 µM 0.358199617332138 0.347252083283156 no 1141 0.360096966795936 1809 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2189 6047310 154.431 µM 0.357424640651018 0.347573092335437 no 1142 0.360386966419571 1690 711535 SGTC_1833 st055984 71 µM 0.355700253644914 0.348287755951903 no 1143 0.361032527529713 1702 676288 SGTC_2045 5106652 78.05 µM 0.355639059435096 0.348313127505721 no 1144 0.361055444176688 1771 673349 SGTC_1491 4138-0063 26.5 µM 0.355626293038252 0.348318420630062 no 1145 0.361060225133225 1789 23883227 SGTC_3231 9132313 49.47 µM 0.355334719601926 0.348439319041626 no 1146 0.361169423943488 1714 4905967 SGTC_2991 9074669 71.4286 µM 0.353536100363984 0.349185441058737 no 1147 0.361843284822401 1758 17333109 SGTC_1168 k815-0004 80.5 µM 0.35241741989383 0.349649798199534 no 1148 0.362262619872503 1678 642433 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.351330156790123 0.350101329860764 no 1149 0.36267033664396 1703 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1072 oxiconazole 14.9 nM 0.349971335151107 0.350665935606813 no 1150 0.363180105086179 1722 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1124 fisetin 1.16336 µM 0.34979611678239 0.350738764865688 no 1151 0.363245856762895 1668 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_822 1487-0950 154 µM 0.34976212520281 0.350752894051431 no 1152 0.363258612760795 1817 1958375 SGTC_524 r073-0010 27.8 µM 0.349560373754994 0.350836759764941 no 1153 0.363334327015961 1663 2772106 SGTC_164 4100-3994 89.624 µM 0.349323013495575 0.350935436949734 no 1154 0.363423411554047 1850 4615967 SGTC_2667 digitoxin 100 µM 0.348277386878877 0.351370252301194 no 1155 0.363815937349064 1808 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2126 5251174 33.877 µM 0.347550965484578 0.351672443339869 no 1156 0.364088718434822 1887 790722 SGTC_37 0566-0070 1.56 µM 0.347521862704343 0.351684552040382 no 1157 0.364099648359354 1816 1626686 SGTC_515 4092-1064 102 µM 0.345946631097723 0.352340177799547 no 1158 0.364691411615132 1839 717353 SGTC_2318 6029776 164 µM 0.345066526622582 0.352706676609007 no 1159 0.365022178768119 1766 818325 SGTC_474 dl-dihydrosphingosine 5 µM 0.344952981473399 0.35275396978216 no 1160 0.365064859439168 1766 3058739 A sphingolipid protein kinase C inhibitor. SGTC_244 nsc-207895 1.295 µM 0.344399449581575 0.352984556279971 no 1161 0.365272951374269 1654 42640 SGTC_2326 6164455 177.58 µM 0.341118346350333 0.354352481864304 no 1162 0.36650724513974 1700 2888790 SGTC_891 0929-0073 133 µM 0.340748736196882 0.354506694339608 no 1163 0.36664637286985 1786 5603632 SGTC_371 0195-0006 7.36 µM 0.339430071830338 0.355057074989046 no 1164 0.367142883881185 1627 3928593 SGTC_1183 1254-0324 198 µM 0.338655448296482 0.355380526462281 no 1165 0.367434653232289 1798 5799357 SGTC_1305 1181-0477 144 µM 0.337670009860388 0.355792156292478 no 1166 0.367805938643839 1827 6252086 SGTC_1679 SEC14.276 6.7 µM 0.336793328145391 0.356158498494732 no 1167 0.368136351463353 1869 1005053 YMR079W SEC14 SGTC_188 3229-0966 278.469 µM 0.336285044931404 0.356370957512711 no 1168 0.368327963166591 1851 5722370 SGTC_2365 9042475 200 µM 0.335898129277366 0.356532715586767 no 1169 0.36847384390167 1698 6464479 SGTC_619 1652-1634 108 µM 0.335611131129323 0.356652717760172 no 1170 0.36858206449132 1707 5400454 SGTC_1691 st019933 84.6 µM 0.334997935627358 0.356909159957086 no 1171 0.368813321734893 1848 6176082 SGTC_841 0251-0215 91.2 µM 0.334542540887206 0.357099650744413 no 1172 0.368985097598169 1765 3888614 SGTC_2749 bexarotene 57.39 µM 0.334489215611379 0.357121958940839 no 1173 0.369005213717837 1657 82146 An retinoic acid receptor inhibitor. SGTC_317 4495-0002 170 µM 0.332759031061556 0.357846032239907 no 1174 0.369658092961118 1694 15991618 SGTC_1231 0242-0792 125 µM 0.330780329128178 0.358674736040728 no 1175 0.370405210171371 1686 3707635 SGTC_972 1319-0219 195 µM 0.32882950006859 0.359492418260554 no 1176 0.371142282041515 1703 23903702 SGTC_2474 5321570 43.32 µM 0.328321953440905 0.359705260091235 no 1177 0.371334123450727 1836 2841384 SGTC_3154 9100113 49.47 µM 0.327903029956746 0.359880970219938 no 1178 0.371492491356621 1687 25237525 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.325886194487059 0.360727310495685 no 1179 0.37225523061024 1766 688801 SGTC_3220 9131269 49.47 µM 0.32553772651979 0.36087361007626 no 1180 0.372387067256994 1740 17722206 SGTC_1040 k898-0338 155 µM 0.325529219210881 0.360877182009948 no 1181 0.372390286032828 1909 20969351 SGTC_1483 3453-0561 55.9 µM 0.323986964092266 0.361524923427106 no 1182 0.372973951772917 1796 4546991 SGTC_3251 9135047 49.47 µM 0.323743412286964 0.361627250630537 no 1183 0.373066150544511 1844 17682963 SGTC_456 gingerol 170 µM 0.323472924652693 0.361740906400821 no 1184 0.373168554641721 1773 442793 A herb. SGTC_2104 5389443 200 µM 0.322617724078081 0.362100331979003 no 1185 0.373492384526302 1823 2244536 SGTC_1079 idarubicin 2.36 µM 0.321423101223249 0.362602614275024 no 1186 0.373944889453682 1837 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3054 9094397 49.47 µM 0.32078017863443 0.362873030723672 no 1187 0.37418849069855 1690 2598354 SGTC_1663 st014140 55.4 µM 0.320689763520293 0.362911065260317 no 1188 0.374222752718509 1799 4207120 SGTC_1389 3405-0187 19 µM 0.318604404883986 0.363788678689107 no 1189 0.37501325639079 1706 799890 SGTC_2906 7926292 26.41 µM 0.318062776806283 0.364016737502228 no 1190 0.375218659180794 1724 2966319 SGTC_3270 9137563 49.47 µM 0.317742824354354 0.364151479847845 no 1191 0.375340012072904 1825 17015724 SGTC_3151 9099821 49.47 µM 0.316669537529747 0.36460359828337 no 1192 0.375747182794484 1705 17174189 SGTC_134 0269-0018 6.916 µM 0.315126357865573 0.365253987532042 no 1193 0.376332858307758 1713 4378915 SGTC_712 r015-0009 80.6 µM 0.313837405639002 0.36579752725029 no 1194 0.376822266513248 1825 6813872 YLR060W FRS1 SGTC_2746 daunorubicin 9.88 µM 0.313538742513133 0.365923509339947 no 1195 0.376935695574262 1872 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_779 1360-0071 233 µM 0.312947675932773 0.366172875674319 no 1196 0.377160207643843 1913 7566 SGTC_2031 5180455 200 µM 0.312109777819365 0.366526475139293 no 1197 0.377478547915667 1748 29949 SGTC_2108 5365811 200 µM 0.311859709378626 0.366632027921184 no 1198 0.377573571856411 1829 780283 SGTC_369 0957-0393 4.5 µM 0.310700085605043 0.367121631712214 no 1199 0.378014316085268 1698 6997992 SGTC_355 1311-2252 105 µM 0.310422920893672 0.367238685232574 no 1200 0.378119683053816 1715 5338538 SGTC_1524 corynanthine 62.1 µM 0.310186417987782 0.367338576023205 no 1201 0.37820959919449 1796 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_755 1995-0008 37.3 µM 0.310027693354195 0.367405620949999 no 1202 0.378269948480064 1770 689533 SGTC_2510 benzyl isothiocyanate 8.31 µM 0.309236945470209 0.367739691264603 no 1203 0.378570645909949 1762 2346 DNA damaging agent; causes G2/M arrest. SGTC_288 1315-0019 35.1 µM 0.30774726564844 0.368369313765752 no 1204 0.379137325577961 1789 6811474 SGTC_2140 5586273 200 µM 0.307564922062109 0.368446406750255 no 1205 0.379206707620004 1763 854421 SGTC_81 0411-0046 9.971 µM 0.30617635931234 0.369033650255448 no 1206 0.379735185577716 1765 12925265 SGTC_2935 9038016 29.96 µM 0.305963080693207 0.369123876033271 no 1207 0.379816377966639 1896 6463195 SGTC_394 menadione 8.33 µM 0.305632801819813 0.369263612041563 no 1208 0.379942121280908 1879 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_1158 4092-0494 91.8 µM 0.305034302942554 0.369516871893126 no 1209 0.380170013276511 1859 1148199 SGTC_2896 9052656 71.43 µM 0.304542869846459 0.36972486829948 no 1210 0.380357168664742 1794 6469436 SGTC_2986 9022445 71.43 µM 0.302509418731972 0.370585920129879 no 1211 0.381131877246592 1897 6459286 SGTC_2931 9014674 55.67 µM 0.300650441841958 0.371373659711189 no 1212 0.381840531437098 1724 2996810 SGTC_964 1287-0107 19.4 µM 0.299431373264943 0.371890531687128 no 1213 0.382305463606189 1887 51516812 YPR165W RHO1 SGTC_2479 5617353 43.85 µM 0.299383382306308 0.371910884069219 no 1214 0.382323770024197 1837 2731746 SGTC_2094 5332512 191.667 µM 0.296214662017666 0.373255489324064 no 1215 0.383533076178183 1878 755774 SGTC_1856 st057054 55.7 µM 0.296117617834128 0.373296693225898 no 1216 0.383570129968542 1903 1266018 SGTC_2100 5377183 190 µM 0.295933875528201 0.373374712173258 no 1217 0.383640290092081 1874 2844202 SGTC_2788 5282734 71.43 µM 0.295677732494188 0.373483481905609 no 1218 0.383738102060157 1908 743706 SGTC_430 0958-0115 16.4 µM 0.294787489857459 0.373861596899161 no 1219 0.384078111826049 1773 6833180 SGTC_19 0279-0214 38.434 µM 0.294519633583194 0.373975387947294 no 1220 0.384180431467181 1817 3566274 YBR002C RER2 SGTC_197 4544-0043 41.561 µM 0.29393101618257 0.374225483726231 no 1221 0.384405308465998 1792 896523 SGTC_1071 trifluoperazine 6.31 µM 0.293463268102428 0.374424261479233 no 1222 0.384584035968497 1858 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_1303 1160-0052 261 µM 0.291723286513426 0.375163989851948 no 1223 0.385249101613187 1860 3562476 SGTC_1502 4534-4282 27.7 µM 0.291597278291764 0.375217578321604 no 1224 0.385297278325735 1808 3278949 SGTC_337 1315-0038 354 µM 0.291384916238841 0.375307896587604 no 1225 0.385378474696408 1785 1626437 SGTC_433 pimozide 108 µM 0.291194752202962 0.375388779766984 no 1226 0.385451187946721 1662 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_3147 9097027 49.47 µM 0.290459485130646 0.375701565166245 no 1227 0.385732370759366 1844 25236841 SGTC_594 1487-1584 10.8 µM 0.290269088802857 0.375782573811765 no 1228 0.38580519243049 1726 5013332 SGTC_598 3937-0236 20.2 µM 0.289369717512392 0.376165306679649 no 1229 0.386149233055295 1862 1379313 SGTC_1413 3910-0535 34.4 µM 0.289317468132519 0.376187545465561 no 1230 0.386169223004983 1884 2876951 SGTC_3309 9129340 25.759 µM 0.289177033025226 0.376247320581298 no 1231 0.386222953192372 1833 17158987 SGTC_673 1082-0474 110 µM 0.28864648965857 0.376473169036129 no 1232 0.38642595769406 1751 3098046 SGTC_2287 7945887 168.79 µM 0.28827838843612 0.37662989190814 no 1233 0.386566824405393 1934 1245853 SGTC_744 1594-0068 283 µM 0.285826818767624 0.377674190429247 no 1234 0.387505383121452 1780 668392 SGTC_2531 methyl deoxycholate 70.07 µM 0.285382669023344 0.377863481471117 no 1235 0.387675491914563 1764 16667744 Haematoxylin. SGTC_3265 9137266 49.47 µM 0.28511832983214 0.377976153439713 no 1236 0.387776743729796 1978 17224265 SGTC_1912 st060209 90.8 µM 0.284010039916895 0.378448663961093 no 1237 0.388201343293424 1740 688787 SGTC_3048 9093155 49.47 µM 0.283544017674702 0.378647403145387 no 1238 0.388379922122008 1917 25236002 SGTC_879 0831-1030 162 µM 0.283196248035557 0.378795733408937 no 1239 0.388513202158227 1777 1549252 SGTC_2168 5727979 200 µM 0.280611758986114 0.379898624399551 no 1240 0.389504097960338 1805 695210 SGTC_310 1273-0058 1.06 µM 0.28035289640432 0.380009144034619 no 1241 0.389603385853801 1858 2734232 SGTC_1811 st050069 61.5 µM 0.278571168789086 0.38077010604106 no 1242 0.390286970556865 1963 3877702 SGTC_1107 amlodipine 47 µM 0.27750219355121 0.381226878731951 no 1243 0.39069726086254 1840 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2944 9067346 25.62 µM 0.277174850636929 0.381366785360349 no 1244 0.390822924830535 1864 6473075 SGTC_3092 9117248 49.47 µM 0.276171500712275 0.38179571445713 no 1245 0.391208172725508 1907 17141857 SGTC_1930 st074634 34.3 µM 0.275556562494693 0.382058670492688 no 1246 0.391444338212136 1732 684253 YOR116C RPO31 SGTC_529 4076-0302 30.3 µM 0.275498702639144 0.382083414965043 no 1247 0.391466561206423 1796 5816522 SGTC_785 1270-0111 65.3 µM 0.275149021505136 0.382232970611899 no 1248 0.391600875367436 1800 6741994 SGTC_2720 fluspirilene 36.88 µM 0.275052696393243 0.382274171130744 no 1249 0.391637876564947 1891 3396 An atypical antipsychotic. SGTC_1910 st062352 60.4 µM 0.274715440472447 0.382418433930995 no 1250 0.391767433817476 1752 2245730 SGTC_475 α-linolenic acid 10 µM 0.274611851029538 0.382462748077827 no 1251 0.39180723023234 1913 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_805 3852-0218 479 µM 0.274460622084467 0.38252744451576 no 1252 0.391865330558314 1758 6615355 SGTC_2097 5376186 200 µM 0.274435198414554 0.382538321200614 no 1253 0.391875098260674 1916 742755 SGTC_2001 4023502 57.655 µM 0.273789804038037 0.382814463065932 no 1254 0.392123079770315 1850 108941 YCR052W RSC6 SGTC_794 k038-0031 316 µM 0.273498019077569 0.382939327293789 no 1255 0.392235207432438 1784 6624242 SGTC_2994 9053520 71.4286 µM 0.273180460777591 0.383075234592584 no 1256 0.392357249489619 1931 4647384 SGTC_577 r071-0003 38.6 µM 0.272417589912644 0.383401783731398 no 1257 0.392650474585893 1787 4568517 YMR134W ERG29 SGTC_464 bw-b 70c 158 µM 0.272185222131376 0.3835012659219 no 1258 0.392739802034636 1917 5353454 SGTC_1527 coumarin 137 µM 0.272050981427061 0.383558741070596 no 1259 0.392791409783079 1892 323 A hepatotoxic, DNA x-linker. SGTC_1364 1653-0028 37.6 µM 0.271891681270831 0.383626948746243 no 1260 0.392852653879568 1819 5718652 SGTC_296 1222-0039 74.9 µM 0.27021308950444 0.384345891549664 no 1261 0.393498161584631 1799 5984176 SGTC_454 lyso-paf C-16 6.67 µM 0.269442484424339 0.384676076065731 no 1262 0.393794598357611 1739 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1820 st053765 18.6 µM 0.269172253360747 0.384791882973936 no 1263 0.393898565573603 1783 3690829 SGTC_1960 st011366 51.8 µM 0.268409824375424 0.385118675566931 no 1264 0.394191939062435 1830 3972846 SGTC_3136 9095672 49.47 µM 0.266074977640353 0.386119945138821 no 1265 0.395090732766341 1987 17217380 SGTC_2927 9011802 47.9 µM 0.265492870886995 0.386369692736326 no 1266 0.395314900540302 1751 43912568 SGTC_2766 oltipraz 83.91 µM 0.265402346622242 0.386408535579969 no 1267 0.395349764310388 1934 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1976 st070609 63.5 µM 0.26440275538232 0.386837523432038 no 1268 0.395734794283177 1873 682556 SGTC_2225 6654152 15.4 µM 0.264188777264528 0.38692937297048 no 1269 0.395817229200037 1903 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_1351 1496-0003 46.5 µM 0.263811442972059 0.387091358139537 no 1270 0.395962608319055 1926 3891978 SGTC_2710 st078562 53.7235 µM 0.263155663647011 0.387372923255055 no 1271 0.396215300986287 1841 17250908 SGTC_2253 7938677 135.83 µM 0.262831923610175 0.38751194598824 no 1272 0.396340064422417 1972 2301972 SGTC_145 3737-0113 38.366 µM 0.262674929944577 0.387579368511807 no 1273 0.396400570707313 1962 6849351 SGTC_1829 berberine 14.4 µM 0.262385293881215 0.387703764555528 no 1274 0.396512204701911 1945 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1306 1185-0270 9.02 µM 0.261638658827094 0.388024490621903 no 1275 0.39680001823743 1932 1548076 SGTC_1500 4488-1866 171 µM 0.261231790410832 0.38819929801499 no 1276 0.396956881910484 1931 2900003 SGTC_2450 5739737 12.93 µM 0.26046520639665 0.388528715533322 no 1277 0.39725247528474 1844 2262825 SGTC_3328 9140624 29.0385 µM 0.260250739425625 0.388620890935303 no 1278 0.397335183924962 1963 4904392 SGTC_148 3253-0744 288.01 µM 0.258750523191916 0.389265841472881 no 1279 0.397913867382732 1816 6893655 SGTC_1919 st067113 52.3 µM 0.258099059337171 0.389546004216685 no 1280 0.398165228766319 1827 1268243 SGTC_1103 duloxetine 36.1 µM 0.257699655131557 0.389717796831711 no 1281 0.398319356141501 1933 60835 A selective serotonin reuptake inhibitor. SGTC_1878 temozolomide 1 mM 0.257383785494049 0.389853674636131 no 1282 0.398441259328802 2007 5394 DNA alkylating agent. SGTC_108 0509-0257 621.132 µM 0.256823151301708 0.39009487607615 no 1283 0.398657648604313 1938 536624 SGTC_2029 5175081 200 µM 0.255838725616925 0.390518507516966 no 1284 0.399037685014365 1855 1380876 SGTC_929 2805-0021 398 µM 0.254938457565539 0.390906036925287 no 1285 0.399385316275206 1854 3098024 SGTC_3223 9129970 49.47 µM 0.253209857181626 0.391650433772461 no 1286 0.400053024871336 1862 17248386 SGTC_849 0386-0493 241 µM 0.252981011904699 0.391749012502554 no 1287 0.40014144316975 1860 726119 SGTC_2173 5763948 167 µM 0.252579427644236 0.3919220180851 no 1288 0.400296614508282 1948 2867177 SGTC_172 1112-0046 2.638 µM 0.252422862526115 0.391989473332242 no 1289 0.400357115216156 1844 2802135 YIL048W NEO1 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.251898403687438 0.392215457271044 no 1290 0.400559796742445 1796 4330530 SGTC_1834 st055981 52.8 µM 0.25032958314607 0.392891662721791 no 1291 0.401166240275049 1965 471719 YDL150W RPC53 SGTC_2020 4017018 200 µM 0.249865343013882 0.393091825274149 no 1292 0.401345742756573 1841 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_2068 5226020 147 µM 0.24910583138838 0.393419358509824 no 1293 0.401639459411493 1817 1810509 SGTC_2741 miltefosine 3.04 µM 0.248655428384193 0.393613626805419 no 1294 0.401813664525614 1884 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_2128 5255449 168.493 µM 0.248229348022587 0.393797428612157 no 1295 0.401978480182826 1849 736008 SGTC_1011 4112-3381 17.4 µM 0.247970529363322 0.393909088910992 no 1296 0.402078604474764 1906 2877139 SGTC_958 1222-0007 33 µM 0.245691682667036 0.394892611101922 no 1297 0.402960455578524 1919 7312461 SGTC_1604 st002052 72.4 µM 0.245507628677562 0.394972075871082 no 1298 0.403031701031958 1888 6254834 YHR062C RPP1 SGTC_3209 9113616 49.47 µM 0.244749684493186 0.395299362052281 no 1299 0.403325127526292 2038 16649353 SGTC_2451 5856223 45.7 µM 0.243804465871151 0.395707618267634 no 1300 0.403691130710676 1833 2179896 SGTC_1963 st076565 50.3 µM 0.242781829770666 0.396149441317529 no 1301 0.404087206124701 1835 4914280 SGTC_88 0180-0332 8.668 µM 0.240436135983649 0.397163385723109 no 1302 0.404996083601179 1888 3101745 SGTC_426 0988-0037 14.6 µM 0.239396963873052 0.397612798661476 no 1303 0.405398892026111 2050 5383008 SGTC_2071 5230951 39.92 µM 0.239237955021579 0.397681577557875 no 1304 0.405460536581627 1994 1799272 SGTC_247 mechlorethamine 29.705 µM 0.238673983301278 0.397925547802096 no 1305 0.405679196051076 1910 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_2784 7567673 72.73 µM 0.237261323567095 0.39853682961278 no 1306 0.406227032411006 1892 3471247 SGTC_1020 4335-0961 93.3 µM 0.235575193962678 0.399266772373554 no 1307 0.406881162055493 1797 669075 SGTC_1100 amiodarone 5.07 µM 0.234856650171722 0.399577944548713 no 1308 0.407159998344789 2039 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1209 2323-2347 50.3 µM 0.234722390078287 0.399636094230204 no 1309 0.40721210419972 2038 5412760 SGTC_2855 9016525 58.44 µM 0.234375828970582 0.399786204353251 no 1310 0.407346610895394 1906 43811474 SGTC_1481 3346-2004 36 µM 0.233620998095548 0.400113204438675 no 1311 0.407639612338173 1983 2770522 SGTC_3045 9092950 49.47 µM 0.233519794722924 0.400157052055427 no 1312 0.407678900214622 2031 44120432 SGTC_1148 3909-7663 27.7 µM 0.233139617007455 0.400321780007976 no 1313 0.407826496227822 2003 4084526 SGTC_924 2046-0044 21.3 µM 0.233009483548254 0.400378169866749 no 1314 0.407877020816699 1940 3623589 SGTC_2284 7945075 39.21 µM 0.232267903987116 0.400699553165484 no 1315 0.408164969855992 2015 1245402 SGTC_231 b-estradiol 524 µM 0.231394366298394 0.401078210265386 no 1316 0.40850422072984 1864 450 A steroid. SGTC_834 0312-0008 75.7 µM 0.230627487083585 0.401410710167347 no 1317 0.408802105796871 1890 6385573 YIL048W NEO1 SGTC_1712 st032288 53.4 µM 0.229152195329467 0.402050560872253 no 1318 0.409375313285215 1918 2883011 SGTC_1064 honokiol 6.76 µM 0.227634004644107 0.402709291488014 no 1319 0.409965390993953 1904 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2663 amphotericin b 100 µM 0.227370768350755 0.402823535737535 no 1320 0.410067724267915 1921 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2959 9079155 11 µM 0.227142812991599 0.402922474806347 no 1321 0.410156347005529 1921 16189457 SGTC_2803 7707263 71.43 µM 0.227100279472846 0.402940936243992 no 1322 0.41017288336912 1864 2199229 SGTC_2265 7929201 200 µM 0.226528203640066 0.403189263593898 no 1323 0.410395312972259 1807 1265108 SGTC_2065 5221596 34.26 µM 0.226390696767661 0.403248958563179 no 1324 0.410448781511092 1937 788581 SGTC_1954 st077032 68.9 µM 0.225501747962178 0.40363492650335 no 1325 0.410794482855226 1803 698907 SGTC_2912 7964298 10.93 µM 0.224874739146213 0.403907220592421 no 1326 0.411038360630751 1863 2975850 SGTC_2630 antimycin a 100 µM 0.224846053963731 0.403919678957565 no 1327 0.411049518679155 1888 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_3063 1327-0034 4 µM 0.224046315647276 0.404267055386493 no 1328 0.411360632231705 1977 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_1757 st041620 31.8375 µM 0.224008352226122 0.404283547156509 no 1329 0.411375402118596 1873 5289815 SGTC_947 3447-0010 211 µM 0.222320279497316 0.40501703792086 no 1330 0.41203228317266 1960 748350 SGTC_532 1548-0774 215 µM 0.222226586859426 0.405057758458969 no 1331 0.412068749100543 2019 5932993 SGTC_2478 5763493 32.33 µM 0.222024959773463 0.405145392772836 no 1332 0.412147226558028 1940 1365576 YLR208W SEC13 SGTC_2382 9035899 200 µM 0.22179858295831 0.405243789868437 no 1333 0.412235341311538 1879 6462679 SGTC_1881 5652484 16 µM 0.220167462251887 0.405952950568277 no 1334 0.412870368122959 2031 2255129 SGTC_1409 3909-8004 61.9 µM 0.21933401978201 0.406315424827158 no 1335 0.413194931532067 1926 2119279 SGTC_1819 st053448 58.6 µM 0.216907441685446 0.407371229328239 no 1336 0.414140239021039 1944 2857616 SGTC_70 0141-0289 43.283 µM 0.216296599755393 0.407637113123956 no 1337 0.414378279669999 1939 352408 SGTC_689 0833-0039 98 µM 0.215436598734027 0.408011521569283 no 1338 0.41471346909506 2023 5374726 SGTC_981 1488-1094 54.9 µM 0.214692109712324 0.408335708783779 no 1339 0.415003687341158 1930 3449522 SGTC_3097 9117246 49.47 µM 0.214686214566729 0.408338276071414 no 1340 0.415005985584301 1959 16423892 SGTC_999 SEC7.066 22.7 µM 0.21342548508885 0.408887403651244 no 1341 0.415497552085658 1948 740511 YDR170C SEC7 SGTC_1316 1272-0050 65.9 µM 0.213012370232589 0.409067380315684 no 1342 0.415658657026814 1929 7340392 SGTC_1402 3909-7673 35.9 µM 0.21208374807169 0.409472011632202 no 1343 0.41602084923542 1946 5328014 SGTC_2485 5633444 17.78 µM 0.210014840973663 0.410373848956353 no 1344 0.416828044957156 1860 5724239 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.209013170897544 0.410810647942211 no 1345 0.417218978402723 1931 689007 SGTC_988 1497-1057 103 µM 0.208970720796288 0.410829161635436 no 1346 0.417235547708731 2077 3533044 SGTC_1252 0493-0875 34.8 µM 0.207977755768489 0.411262278434034 no 1347 0.41762316795677 1919 3960963 SGTC_1779 st039427 55 µM 0.20744464744219 0.411494857141396 no 1348 0.417831308621981 2104 1124498 SGTC_632 0781-2353 4.65 µM 0.207156104443758 0.411620752523811 no 1349 0.417943973626818 1983 6811515 YHR007C ERG11 SGTC_555 4296-0685 37 µM 0.204754480144284 0.412668966973722 no 1350 0.418881976511463 1981 2908540 YHR072W ERG7 SGTC_3126 9127922 49.47 µM 0.204193817105331 0.412913764301118 no 1351 0.419101021403878 1973 45595682 SGTC_872 0588-0139 234 µM 0.203364312574578 0.413276005601044 no 1352 0.419425145695169 1965 2047100 SGTC_3191 9110352 49.47 µM 0.202377088891463 0.413707218432158 no 1353 0.419810969117733 1980 17122424 SGTC_1164 k060-0068 93.7 µM 0.20130232272112 0.414176787571116 no 1354 0.420231093236354 2034 5963676 SGTC_1638 st008370 60.6 µM 0.200857007522989 0.414371383348644 no 1355 0.420405192790323 2010 24207134 SGTC_3052 9092717 49.47 µM 0.200752131314862 0.414417215671472 no 1356 0.420446197253272 1931 25237534 SGTC_533 1222-0222 6.71 µM 0.199397029040133 0.415009518299751 no 1357 0.42097609215301 2040 3982874 SGTC_2504 purpurogallin 52.29 µM 0.197377734923331 0.415892491159423 no 1358 0.421765975923848 1903 5281571 An antioxidant. SGTC_269 exalamide 29 µM 0.196794604734683 0.416147554614867 no 1359 0.421994136678226 1965 3316 A derivative of salicylamide. SGTC_880 0833-0487 87.2 µM 0.194892488400262 0.4169797928025 no 1360 0.422738557413915 1906 76075 SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.193090545070422 0.417768545385068 no 1361 0.423444028630253 2062 77254 SGTC_966 1300-0360 30.2 µM 0.192341754058996 0.41809640616911 no 1362 0.423737256965959 1935 70588 SGTC_1287 0971-0001 34.6 µM 0.191576934638966 0.418431343813009 no 1363 0.424036805663986 1976 4665869 SGTC_1415 3966-0071 78.1 µM 0.191110674806722 0.418635562187135 no 1364 0.424219442246587 2027 2893185 SGTC_3030 9087619 49.47 µM 0.189767133512603 0.41922414584123 no 1365 0.424745805763066 1958 25236973 SGTC_2607 solasodine 47.35 µM 0.189042992109432 0.419541455520574 no 1366 0.425029560705918 1934 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_215 1287-0124 461.5 µM 0.188814370938869 0.419641645327125 no 1367 0.425119154029002 2085 5560863 SGTC_3019 9081971 49.47 µM 0.186809827263781 0.420520328970218 no 1368 0.425904870759227 2061 16451803 SGTC_1774 st048371 48.465 µM 0.186771744915865 0.420537026062665 no 1369 0.425919800674452 1903 4242727 SGTC_2680 butyl paraben 22.24 µM 0.186614025953974 0.42060617899545 no 1370 0.425981634408633 2080 7184 An antifungal and steroid mimetic. SGTC_1880 MG-132 525 µM 0.186160850096683 0.420804890606066 no 1371 0.42615931216926 2064 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_705 1124-0212 310 µM 0.18497302207859 0.421325833100096 no 1372 0.42662509783785 2081 9554485 SGTC_1492 4158-0558 28.5 µM 0.184936683251944 0.421341772296315 no 1373 0.426639349080298 2078 3967268 SGTC_1042 0350-0096 82 µM 0.18450108756414 0.421532846420642 no 1374 0.426810187025351 1890 3122515 SGTC_803 4488-1585 147 µM 0.184106504266323 0.42170594640438 no 1375 0.42696495201674 2064 747204 SGTC_2770 toltrazuril 17.5 µM 0.183340106196725 0.422042201236001 no 1376 0.427265583745917 2086 68591 Kills coccidiodes. SGTC_1403 3909-7815 62.9 µM 0.182446269069636 0.422434441352427 no 1377 0.427616258809418 1985 6615483 SGTC_1704 st028805 70.8 µM 0.181786460559366 0.422724032704314 no 1378 0.427875155193724 1975 2876101 SGTC_1400 3771-8998 51.5 µM 0.180528452286847 0.423276290808802 no 1379 0.428368859814241 2036 670767 SGTC_2463 5473429 200 µM 0.180268699174792 0.423390339686512 no 1380 0.428470813765376 1971 5399405 SGTC_1037 k284-1091 78.7 µM 0.179447869770989 0.42375078048997 no 1381 0.428793023355725 2030 3334711 SGTC_2404 5161160 200 µM 0.179287424484999 0.423821242335394 no 1382 0.428856010338129 1986 2831543 SGTC_377 3970-0964 33.1 µM 0.178490483086034 0.42417126661744 no 1383 0.429168897293812 2015 16481235 SGTC_2061 5245884 80.95 µM 0.178473470285746 0.424178739455112 no 1384 0.429175577170835 1990 573863 SGTC_837 0091-0265 12.5 µM 0.177983400070885 0.424394013485063 no 1385 0.429368006207685 1963 759367 SGTC_819 1013-0258 27.7 µM 0.17752410766233 0.424595788170179 no 1386 0.429548365390499 1990 5753198 SGTC_2857 9024691 58.44 µM 0.177396138033515 0.424652010848382 no 1387 0.429598620306821 1968 16478292 SGTC_1916 st067606 49.2 µM 0.176266553015238 0.425148353517275 no 1388 0.430042268706767 2052 19590279 SGTC_171 k064-0041 9.68 µM 0.176133807318863 0.425206690137633 no 1389 0.430094410846971 1939 53325 SGTC_2378 9074213 121.43 µM 0.175663514395394 0.425413378932567 no 1390 0.430279150403457 2088 657714 SGTC_163 TUB2.036 7.546 µM 0.175436014936788 0.425513369912831 no 1391 0.430368521780481 2113 15992207 YJR013W GPI14 SGTC_1268 0828-0275 2.46 µM 0.17526012334804 0.425590681391471 no 1392 0.430437621856099 2035 745337 SGTC_341 1486-1430 230 µM 0.173788086488059 0.426237813102997 no 1393 0.431016003762028 1976 2054753 YPL210C SRP72 SGTC_530 4358-1714 28 µM 0.172678113878087 0.426725906867513 no 1394 0.431452223970785 2041 1564641 SGTC_2241 6772625 37.8075 µM 0.170913395706631 0.427502145909928 no 1395 0.432145931698771 2158 2285411 SGTC_459 nigericin 15.3 µM 0.170617974843755 0.42763211893539 no 1396 0.432262081645094 2015 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_1177 0983-0204 23.6 µM 0.170178553043729 0.427825460974042 no 1397 0.432434858938994 2138 766818 SGTC_1172 0370-0043 85 µM 0.168380845627818 0.428616617700756 no 1398 0.433141837966902 2047 376585 SGTC_1373 2887-0003 58.5 µM 0.167889748347115 0.42883279574043 no 1399 0.433335007643079 1998 776948 SGTC_520 3584-0023 682 µM 0.167471103685689 0.429017097438713 no 1400 0.433499691166751 1946 1340790 SGTC_2940 9060638 45.86 µM 0.167117918908282 0.429172593495033 no 1401 0.43363863351742 1990 4027022 SGTC_3278 9139605 49.47 µM 0.166837592295348 0.429296020237817 no 1402 0.433748919416472 2080 7958859 SGTC_2096 5468907 200 µM 0.165765218928157 0.429768245858065 no 1403 0.434170859327401 2113 759785 SGTC_309 k408-0051 1.48 µM 0.165410319070901 0.429924550164948 no 1404 0.434310516054799 2025 3640463 SGTC_1235 benzylparaben 21.5 µM 0.165087381315462 0.430066787329827 no 1405 0.434437602492703 2054 7180 SGTC_1396 3511-0007 98.6 µM 0.165079498265157 0.430070259514103 no 1406 0.434440704812394 1993 X1396 SGTC_9 0092-0002 10.449 µM 0.164051715964994 0.430523004803384 no 1407 0.43484521590445 2093 759368 SGTC_2941 9056145 11.23 µM 0.163842201835818 0.430615308469406 no 1408 0.43492768415206 2149 2119517 SGTC_224 benfluorex 43.875 µM 0.163299700900323 0.430854330599615 no 1409 0.435141234694337 2116 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_1986 st071812 45 µM 0.162833934161994 0.431059564390517 no 1410 0.435324594617006 2120 11838594 SGTC_2341 7987486 176.74 µM 0.162431751813304 0.431236795563778 no 1411 0.435482934254275 2125 1258686 SGTC_2291 7917025 104.35 µM 0.16172198298568 0.43154960575913 no 1412 0.435762396250563 1970 2964612 SGTC_568 1193-0097 7.48 µM 0.161574597988397 0.431614566846809 no 1413 0.435820431151696 2093 3646150 SGTC_3348 9149464 3.537 µM 0.159536253787969 0.432513171869202 no 1414 0.436623198839347 2155 1951442 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.159518683011692 0.432520919478958 no 1415 0.436630119934688 2097 3256 An antibiotic and ribosome inhibitor. SGTC_1696 st025591 34.7925 µM 0.159334314320893 0.432602216066115 no 1416 0.436702743580471 2056 2787147 SGTC_2364 9055074 200 µM 0.158374097074459 0.4330256658105 no 1417 0.437081011852118 1986 6470630 SGTC_202 3594-0513 34.79 µM 0.157272692755515 0.433511472842861 no 1418 0.437514970220303 2121 708429 SGTC_1977 st070720 65.3 µM 0.156268862883102 0.433954329308402 no 1419 0.437910549303035 1985 682188 SGTC_2258 7960471 200 µM 0.155934745087222 0.434101749423619 no 1420 0.438042228835809 1973 2974708 SGTC_1113 artemisinin 1.17947 µM 0.154947703081114 0.434537307508047 no 1421 0.438431273065444 2160 2240 An anti-malaria and mitochondrial poison. SGTC_2528 xanthyletin 44.79 µM 0.15343442278635 0.43520523613297 no 1422 0.439027850403345 2022 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2826 7992541 19.48 µM 0.152256285071973 0.435725368322571 no 1423 0.439492401159047 2150 2985066 SGTC_906 1165-0455 526 µM 0.151062795770571 0.436252391416784 no 1424 0.439963090160794 2101 3252859 SGTC_2779 methotrexate 400 µM 0.150413685113892 0.436539074421266 no 1425 0.440219122470575 2141 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_250 brefeldin a 552.239 µM 0.148914797706838 0.43720119274699 no 1426 0.440810432264428 2046 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_2866 9034245 58.44 µM 0.148651893242687 0.437317346317703 no 1427 0.440914161493157 2171 6462273 SGTC_1443 4112-3303 14 µM 0.148527371434382 0.437372363065236 no 1428 0.440963293116843 2076 704433 SGTC_237 nikkomycin 200 µM 0.148226736777649 0.437505195719153 no 1429 0.441081915992718 2144 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_2014 4013930 200 µM 0.147844111223091 0.437674265481655 no 1430 0.441232898059098 2181 64556 SGTC_2675 theaflavin digallate 100 µM 0.147237616651403 0.437942278969243 no 1431 0.441472235173037 2108 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_3257 9139206 32.98 µM 0.146639325365228 0.438206695273155 no 1432 0.441708356018509 2118 4910041 SGTC_691 1548-0686 185 µM 0.145899039359469 0.438533904667851 no 1433 0.44200054497767 2014 46495133 SGTC_2311 7694451 200 µM 0.145176752654585 0.438853198799976 no 1434 0.442285660079321 2081 2163142 SGTC_3018 9082602 49.47 µM 0.144724119159142 0.439053310304419 no 1435 0.442464347652781 2057 17332089 SGTC_1875 nocodazole 6 µM 0.144262017032296 0.439257624007588 no 1436 0.442646785263436 2176 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.144068180801265 0.439343331524701 no 1437 0.442723315300873 2068 2724278 An inhibitor of dopamine biosynthesis. SGTC_949 1165-0505 146 µM 0.141255278260219 0.44058741545014 no 1438 0.443834139034288 2019 6244267 SGTC_3187 9109394 49.47 µM 0.140659862197989 0.440850830315208 no 1439 0.444069327543501 2018 17098090 SGTC_1684 st024538 14.6195 µM 0.140262540840203 0.441026621719022 no 1440 0.4442262798854 2032 6732859 SGTC_1928 4'-methoxychalcone 40.3 µM 0.140206303760184 0.441051504269049 no 1441 0.444248495712031 2197 641818 SGTC_1659 st012954 42.1 µM 0.139573702823182 0.441331419669342 no 1442 0.44449840965638 2112 24207262 SGTC_570 0987-0065 62.6 µM 0.139376253478475 0.44141879373058 no 1443 0.444576418086506 2160 3104428 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.13833792292217 0.441878316158105 no 1444 0.444986677733788 2198 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1253 0550-0034 176 µM 0.137660607754017 0.442178110211987 no 1445 0.445254326688239 2057 5969915 SGTC_1057 3448-5381 134 µM 0.13728569302838 0.442344069669691 no 1446 0.445402489334167 2143 5497911 SGTC_1501 4491-0275 38.4 µM 0.137242694542096 0.442363103993191 no 1447 0.445419482404774 2186 5104718 SGTC_2344 7990960 76.95 µM 0.137177263392663 0.442392068934739 no 1448 0.445445341092159 2050 140813 SGTC_936 3005-4620 401 µM 0.137032679596455 0.442456074117057 no 1449 0.445502482087921 2180 777207 SGTC_1677 st019204 53.9 µM 0.136702959439686 0.442602042138773 no 1450 0.445632795100735 1976 3945625 SGTC_2865 9030313 51.95 µM 0.136440454729827 0.442718259269149 no 1451 0.445736547218654 1989 42562754 SGTC_743 1275-0778 158 µM 0.134291761731853 0.443669721596705 no 1452 0.446585933710578 2154 2849257 YMR203W TOM40 SGTC_800 3448-7362 155 µM 0.133898368888678 0.443843955144943 no 1453 0.44674147005504 2187 15991913 SGTC_3094 9117742 49.47 µM 0.133464319245301 0.444036208170035 no 1454 0.44691309044823 2182 17149698 SGTC_835 0312-0010 67.2 µM 0.132409913955344 0.444503289256046 no 1455 0.447330036759506 2084 1626196 SGTC_2843 9000894 45.46 µM 0.1321972765925 0.444597492842431 no 1456 0.447414127590601 2186 2242070 SGTC_1069 diphenylcyclopropenone 8.49 µM 0.131928330682518 0.444716646983052 no 1457 0.447520489918491 2110 65057 A dermal irritant. YDR527W RBA50 SGTC_402 epigallocatechin gallate 10 µM 0.131726316801372 0.444806150757985 no 1458 0.447600384549735 2029 65064 An antioxidant. SGTC_409 arachidonic acid 100 µM 0.131641554927482 0.444843705984387 no 1459 0.447633907724321 2146 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3353 9151644 39.2805 µM 0.131472822119756 0.44491846747084 no 1460 0.447700642371308 2082 4909158 SGTC_2317 5986382 200 µM 0.131451429330324 0.444927946246088 no 1461 0.447709103429472 2138 877883 SGTC_1855 st056195 39.6 µM 0.13054315086033 0.445330417719749 no 1462 0.448068358379843 2205 4028379 SGTC_535 2293-4129 48.2 µM 0.130538369355021 0.445332536624156 no 1463 0.448070249740392 2172 396118 YIL048W NEO1 SGTC_2205 7238770 200 µM 0.129622645406885 0.445738364643969 no 1464 0.448432492978927 2194 279867 SGTC_2111 5486399 200 µM 0.129399474837879 0.445837277395968 no 1465 0.448520781603292 2136 689674 SGTC_1286 0929-0070 131 µM 0.128445486603041 0.446260138112002 no 1466 0.448898218074149 2121 1420408 SGTC_1761 st044296 37 µM 0.128017729339777 0.446449763830973 no 1467 0.449067471250604 2133 1826700 SGTC_1739 st037196 92.5 µM 0.127332841743722 0.446753401465378 no 1468 0.449338483952364 2174 612214 SGTC_591 4299-0174 154 µM 0.127024930821754 0.446889920682235 no 1469 0.449460333218224 2116 5509088 SGTC_3285 9112818 20.8695 µM 0.126115453438615 0.447293194578866 no 1470 0.449820267533202 2171 17017947 YPR165W RHO1 SGTC_2316 5844804 197.44 µM 0.125610219145438 0.44751724549568 no 1471 0.450020236661899 2191 776813 SGTC_3239 9133757 49.47 µM 0.125210830057041 0.447694370213209 no 1472 0.450178321788048 2124 17036923 SGTC_1175 0741-0056 27.6 µM 0.124988650364342 0.447792909008364 no 1473 0.4502662677866 2163 765927 SGTC_2594 a-mangostin 100 µM 0.124819193530318 0.447868066883191 no 1474 0.450333345993017 2168 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_271 rotenone 740 µM 0.1237934014562 0.448323068343248 no 1475 0.450739428250703 2120 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2588 indole-3-carbinol 100 µM 0.12240578938587 0.448938667161187 no 1476 0.451288826862203 2183 3712 Induces cell cycle arrest. SGTC_422 cantharidin 155 µM 0.121147707742744 0.44949690753909 no 1477 0.451787021055741 2121 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1080 nisoldipine 24.4 µM 0.120946040188959 0.449586401495533 no 1478 0.45186688750541 2144 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2608 thymoquinone 42.66 µM 0.120778950669846 0.44966055270947 no 1479 0.451933061483512 2209 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_1445 4239-0156 97.7 µM 0.120547278182146 0.449763367548684 no 1480 0.452024815049666 2184 4008346 SGTC_2602 kawain 100 µM 0.118804720109045 0.450536811814313 no 1481 0.452715034533305 2226 5369129 SGTC_944 3370-0224 231 µM 0.118683827725511 0.450590477586239 no 1482 0.4527629247923 2096 4580514 SGTC_1181 1222-0449 220 µM 0.11840087192851 0.450716089039619 no 1483 0.452875017470187 2160 658318 SGTC_1966 st070145 16.1 µM 0.11817504405306 0.450816343462179 no 1484 0.452964481669738 2161 3748532 SGTC_1421 4029-0249 71.4 µM 0.116191355940324 0.451697119574421 no 1485 0.453750443656336 2223 2894095 SGTC_1437 4092-1038 11.6 µM 0.116050864080518 0.451759508345674 no 1486 0.453806115190481 2154 3977136 SGTC_1597 7-benzyloxygramine 47.5 µM 0.115807288247824 0.451867676843643 no 1487 0.453902637098719 2054 260807 SGTC_3115 9123671 49.47 µM 0.11481657585347 0.452307674603227 no 1488 0.454295255158094 2218 3286988 SGTC_1302 1159-0335 255 µM 0.113925177165023 0.452703614982491 no 1489 0.454648553504735 2114 649284 SGTC_2634 4'-methoxyflavone 100 µM 0.113844278264163 0.452739550891141 no 1490 0.454680618881369 2101 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_807 1315-0151 48 µM 0.113775245447104 0.45277021610099 no 1491 0.454707981208271 2226 4011080 SGTC_2617 dihydrotanshinone i 20.83 µM 0.113641700085452 0.452829539360537 no 1492 0.454760914785379 2143 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_3091 9116372 49.47 µM 0.113399689998262 0.452937047290404 no 1493 0.454856842736274 2122 17169793 SGTC_438 sphingosine 6.67 µM 0.112383804921883 0.4533883705758 no 1494 0.455259547887284 2048 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_1059 3448-6867 171 µM 0.111648351038013 0.45371514540012 no 1495 0.455551116536499 2243 3934407 SGTC_839 0122-0028 230 µM 0.111466547375909 0.453795928736997 no 1496 0.455623195790116 2133 759448 SGTC_2146 5545642 200 µM 0.110495451997672 0.45422746127934 no 1497 0.456008228282728 2193 825326 SGTC_1459 k035-0031 35.7 µM 0.110415134910722 0.454263154779439 no 1498 0.456040075298071 2130 3877128 YMR208W ERG12 SGTC_634 1611-4317 11.2 µM 0.109690908663186 0.454585022860537 no 1499 0.456327255371217 2225 2843522 SGTC_1282 0886-0010 32.4 µM 0.109642103177724 0.45460671457151 no 1500 0.456346609210435 2203 2836211 YNL267W PIK1 SGTC_3071 9117417 49.47 µM 0.108888924271542 0.454941483804622 no 1501 0.456645295779024 2215 45595590 YGL055W OLE1 SGTC_615 k087-0205 167 µM 0.108776535663736 0.454991440486664 no 1502 0.456689867596449 2143 9642773 SGTC_3279 9140807 49.47 µM 0.108299418883578 0.455203526581354 no 1503 0.45687909178487 2196 45595718 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.108222188124699 0.455237858100061 no 1504 0.456909722371553 2229 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_3253 9135987 49.47 µM 0.10683212269497 0.455855843128165 no 1505 0.45746108153683 2174 4182430 SGTC_1260 0700-1617 7.75 µM 0.106029236342483 0.456212833177474 no 1506 0.457779577840891 2133 2853078 SGTC_2534 helenine 20.12 µM 0.105687468157238 0.456364805453853 no 1507 0.457915161810857 2157 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2155 5570423 76 µM 0.105625205694708 0.456392492066339 no 1508 0.457939862683 2094 797402 SGTC_1270 0831-1170 17.3 µM 0.105582840961164 0.456411330760629 no 1509 0.457956669786459 2203 6764716 SGTC_421 streptovitacin 30 mM 0.105431278174753 0.456478728304186 no 1510 0.458016798985643 2096 91467 include heat shock SGTC_1077 5-fluorocytosine 377 nM 0.105092706389735 0.456629290273859 no 1511 0.458151123356979 2149 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_1965 Pectolinarigenin 58.4 µM 0.104891121751356 0.456718937383569 no 1512 0.458231101960978 2155 5320438 An anti-inflammatory. SGTC_331 k048-0133 24.5 µM 0.104316881655831 0.456974320910543 no 1513 0.458458940689667 2209 6813582 SGTC_3119 9125183 49.47 µM 0.103584602196333 0.457300015525649 no 1514 0.458749503794981 2219 22695334 SGTC_1450 4112-4260 37.6 µM 0.102762446509879 0.457665718395007 no 1515 0.459075755383473 2220 1633175 SGTC_3193 9111931 49.47 µM 0.101736194778638 0.45812225543904 no 1516 0.45948303595355 2149 17087244 SGTC_629 3448-6466 76.7 µM 0.101048426866021 0.458428245961001 no 1517 0.459756008899626 2199 573744 SGTC_1101 ebselen 5.29 µM 0.100786713012676 0.458544689916157 no 1518 0.459859887304386 2246 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_2420 aureobasidin a 50 nM 0.0988914197289888 0.459388065486106 no 1519 0.460612240788138 2207 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_659 k018-0002 107 µM 0.098333800009808 0.459636232423977 no 1520 0.460833619852101 2237 6797879 YHR007C ERG11 SGTC_2089 5281248 129.67 µM 0.0972077754636881 0.460137414025212 no 1521 0.461280696682021 2179 2737878 SGTC_3204 9114183 49.47 µM 0.0971295849805676 0.460172218142268 no 1522 0.461311743258105 2154 17027248 SGTC_680 0417-1641 114 µM 0.096487234865826 0.460458152299245 no 1523 0.461566805862066 2140 2835990 SGTC_1129 3453-1384 223 µM 0.0948272924663148 0.461197149330864 no 1524 0.462226004148184 2161 1084452 SGTC_3076 9116187 49.47 µM 0.0944459389626779 0.461366944791405 no 1525 0.462377462425883 2218 27241210 SGTC_2226 7298446 200 µM 0.0930164631670842 0.462003473116934 no 1526 0.462945241104756 2247 3283010 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.0926847553510783 0.462151192578243 no 1527 0.463077004170546 2186 521171 SGTC_33 0986-0033 35.816 µM 0.0924544813134903 0.462253743600397 no 1528 0.463168477455775 2243 2848082 SGTC_2075 5212009 200 µM 0.091711924143023 0.4625844535909 no 1529 0.46346346161309 2234 780898 SGTC_832 4083-0019 164 µM 0.0915716284622492 0.462646939480755 no 1530 0.463519196961075 2210 1990758 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.0909515193521452 0.462923139114508 no 1531 0.463765556635694 2188 442882 SGTC_914 3820-6779 408 µM 0.0904014576921665 0.46316815423614 no 1532 0.463984099183527 2217 2893481 SGTC_2537 larixol 68.93 µM 0.0903068169187466 0.463210311686263 no 1533 0.464021701585222 2205 6708759 SGTC_3149 9097855 49.47 µM 0.0895173027227225 0.463562014484303 no 1534 0.464335401601268 2244 25236625 YMR079W SEC14 SGTC_602 3130-1533 38.1 µM 0.0887393390474513 0.463908599761997 no 1535 0.464644533902995 2236 720941 SGTC_389 tpck 16.7 µM 0.0876651796782658 0.464387186123329 no 1536 0.465071397813777 2160 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1703 st026983 48.3 µM 0.0875377219867705 0.464443977696948 no 1537 0.465122051344532 2254 1104023 SGTC_326 k292-0812 17.5 µM 0.0871644654583949 0.464610294503058 no 1538 0.465270392137386 2248 3579357 SGTC_2497 7-hydroxyflavone 100 µM 0.0868344762514035 0.464757337272128 no 1539 0.465401541514406 2244 5281894 SGTC_3133 9127736 49.47 µM 0.0867752630877072 0.464783723092111 no 1540 0.465425075317117 2273 27243420 SGTC_338 4055-0136 114 µM 0.0857828627401268 0.465225966921028 no 1541 0.465819514903867 2244 2900563 SGTC_2852 9023854 51.95 µM 0.0856713146975468 0.465275678822653 no 1542 0.465863852911648 2223 19798528 SGTC_2012 4023501 200 µM 0.0854983272647138 0.465352772544569 no 1543 0.465932612626537 2146 3477460 SGTC_360 0957-0399 1.01 µM 0.084109754874593 0.465971651730351 no 1544 0.466484584430511 2243 6752301 YPR165W RHO1 SGTC_3111 9122088 49.47 µM 0.0839177779394821 0.466057221318922 no 1545 0.466560902333025 2250 16876704 SGTC_1877 wortmannin 25 µM 0.0824596533552065 0.466707199920722 no 1546 0.467140600493603 2262 312145 A covalent inhibitor of PI 3-kinase. SGTC_2141 5621638 7.665 µM 0.0817324609740161 0.46703138897735 no 1547 0.467429732290709 2248 2856238 SGTC_1275 0867-0008 21.1 µM 0.0805927921739913 0.467539507736243 no 1548 0.467882899285712 2195 3422836 SGTC_769 0302-0231 76 µM 0.0804985648033383 0.467581521175336 no 1549 0.467920368826662 2241 571869 YER009W NTF2 SGTC_1060 3448-7350 82 µM 0.0797537848525035 0.467913611106037 no 1550 0.468216540762092 2260 570178 SGTC_1938 st074717 56.4 µM 0.0796474446686387 0.467961028957643 no 1551 0.468258829829944 2272 17250979 SGTC_1469 k284-2957 126 µM 0.0773588780318751 0.468981626309665 no 1552 0.469169026643268 2218 23884841 SGTC_2249 haloperidol 116.36 µM 0.0768064564881846 0.469228012164382 no 1553 0.469388757189603 2205 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2257 7960413 200 µM 0.0757283556440911 0.469708890405736 no 1554 0.469817608110383 2205 2974689 YIL048W NEO1 SGTC_3243 9134147 49.47 µM 0.0754712712694139 0.4698235673814 no 1555 0.469919877267732 2287 24282180 SGTC_192 3455-0609 60.9 µM 0.0754459350168185 0.469834869195054 no 1556 0.469929956234411 2219 3769639 SGTC_1552 6-methylflavone 10.6 µM 0.0751983230119708 0.46994532345834 no 1557 0.470028459310515 2280 689013 SGTC_1046 2001-0062 216 µM 0.0750776007376165 0.469999175845941 no 1558 0.4700764847694 2221 739778 SGTC_1958 st076513 41.9 µM 0.0750362486839497 0.470017622500233 no 1559 0.470092935448868 2218 732122 YGL099W LSG1 SGTC_452 diindolylmethane 8 µM 0.0743377959090445 0.470329203581469 no 1560 0.470370801714217 2240 3071 Inhibits expression of several cancer promoting factors. SGTC_3299 9121982 43.1275 µM 0.0739520972230675 0.470501272280426 no 1561 0.470524250855109 2167 17594604 YPL160W CDC60 SGTC_575 k072-0246 11.9 µM 0.073078771774199 0.470890902348847 no 1562 0.470871717076506 2266 6796779 SGTC_2303 7774051 200 µM 0.0722715250940366 0.471251076475613 no 1563 0.471192912552827 2243 2953184 SGTC_2681 menadione 3.18 µM 0.0722027414832454 0.47128176716604 no 1564 0.471220281741131 2218 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_782 0083-0095 30.5 µM 0.0719071073005241 0.471413678685172 no 1565 0.471337916943192 2314 3591729 An indicator and reagent. SGTC_540 1187-0821 17.3 µM 0.0717440731749342 0.471486425604661 no 1566 0.471402790594121 2154 847520 SGTC_158 k038-0087 26.446 µM 0.0695408014834322 0.47246963251385 no 1567 0.472279578178308 2171 X158 SGTC_3236 9132701 49.47 µM 0.0693631241786462 0.472548928152839 no 1568 0.472350290418637 2194 24282524 SGTC_2368 9071271 200 µM 0.068655131616596 0.472864909065381 no 1569 0.472632066834299 2222 27209959 SGTC_2312 7706453 155.7 µM 0.0686033884605543 0.472888002988007 no 1570 0.47265266081125 2214 976098 SGTC_380 3970-0968 6 µM 0.0681428584365061 0.473093550017749 no 1571 0.472835956762843 2259 2891601 SGTC_2627 acetyl isogambogic acid 100 µM 0.0657815050842917 0.47414759738054 no 1572 0.473775890571627 2208 6857789 A caspase activator and apoptosis inducer. SGTC_1001 4048-4355 44.4 µM 0.065561101581863 0.474245989180857 no 1573 0.473863629446578 2269 21824233 SGTC_3315 9136395 68.55 µM 0.0647618756081223 0.474602790121079 no 1574 0.474181798277574 2287 16876844 SGTC_845 0330-0138 4.51 µM 0.0644593901234856 0.474737834987333 no 1575 0.474302220909463 2295 9039800 SGTC_1835 st008666 49.2 µM 0.0641765442620473 0.474864114355699 no 1576 0.47441482692667 2167 690455 SGTC_2426 5582046 32.21 µM 0.0620182280324947 0.475827798490701 no 1577 0.475274158035971 2280 2251934 SGTC_968 1309-0633 340 µM 0.0618531341429868 0.475901518495222 no 1578 0.475339894763681 2301 3761976 SGTC_940 3232-1287 54.8 µM 0.0614168351261024 0.476096344724197 no 1579 0.475513622588621 2311 1585493 YIL048W NEO1 SGTC_2918 7977171 22.06 µM 0.0595301036062456 0.476938916488677 no 1580 0.476264944388517 2320 2236483 SGTC_3188 9110789 49.47 µM 0.0592903349198079 0.477045999241496 no 1581 0.476360429594986 2285 849217 SGTC_572 0960-0087 17.7 µM 0.0584807583177144 0.477407575300112 no 1582 0.476682844449162 2281 6796365 SGTC_344 k064-0035 6.43 µM 0.0579612768657205 0.477639597818344 no 1583 0.476889736614778 2228 5088750 SGTC_1981 st071826 47 µM 0.0577916078583255 0.47771538086164 no 1584 0.47695731148341 2205 11838600 SGTC_3005 9076496 71.4286 µM 0.0560398301346166 0.478497862929857 no 1585 0.477655038570244 2324 21368410 SGTC_1446 4239-0190 62 µM 0.0553837208676551 0.478790954564168 no 1586 0.477916382398107 2222 1340085 SGTC_3196 9111891 49.47 µM 0.0551588360322096 0.4788914158809 no 1587 0.478005961534157 2314 18891510 SGTC_776 4476-4378 112 µM 0.0538968883299974 0.479455182136096 no 1588 0.478508657908649 2179 2892008 SGTC_2769 toremifene 3.73 µM 0.0537383249420227 0.479526022143816 no 1589 0.478571824006819 2277 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3064 1327-0027 10 µM 0.0536761096595536 0.47955381770985 no 1590 0.478596608542624 2260 16000455 YPR107C YTH1 SGTC_1924 st058459 75.1 µM 0.0535790849521313 0.479597165082031 no 1591 0.478635260181169 2323 688683 SGTC_2008 4012253 172 µM 0.0533575233008035 0.479696152271076 no 1592 0.478723524233938 2284 603940 SGTC_1825 st052143 62.6 µM 0.0531085408082653 0.479807391774443 no 1593 0.478822713238721 2298 674173 SGTC_3267 9137951 49.47 µM 0.0521816177843345 0.480221532869128 no 1594 0.479191989929734 2208 16643986 SGTC_2144 5628481 200 µM 0.0513192903489105 0.480606832399856 no 1595 0.47953554844084 2302 2818399 SGTC_1641 st009299 47.1 µM 0.0508689712365169 0.480808048278242 no 1596 0.479714965426113 2320 4046054 SGTC_3284 9108171 64.8615 µM 0.0501382806493033 0.481134552793485 no 1597 0.480006097269122 2250 8687505 SGTC_1936 st074407 74.3 µM 0.0498345109999108 0.481270294096806 no 1598 0.480127132519063 2319 809813 SGTC_2811 7967822 32.47 µM 0.0484010957449992 0.481910853402648 no 1599 0.480698293025964 2299 2232244 SGTC_2453 5731132 22.18 µM 0.0477582775066095 0.482198128905588 no 1600 0.480954444157615 2304 1362040 SGTC_2610 ononetin 44.17 µM 0.0474389008519089 0.482340861794974 no 1601 0.481081712754815 2270 259632 SGTC_795 0685-0265 78 µM 0.0470780821392611 0.482502118311452 no 1602 0.481225497941986 2343 302754 SGTC_1555 citronellol 128 µM 0.0455575501152508 0.483181703168534 no 1603 0.48183145205919 2334 8842 A terpine precursor. SGTC_414 piperonyl butoxide 100 µM 0.0453849663995207 0.483258840663279 no 1604 0.48190023185768 2306 5794 A potent inhibitor of cytochrome P450. SGTC_169 k015-0017 16.025 µM 0.0451416670609731 0.483367586062269 no 1605 0.481997194872136 2296 1840002 SGTC_3228 9131799 49.47 µM 0.0450921812096267 0.483389704476505 no 1606 0.482016916787957 2252 17015818 SGTC_82 0054-0107 293.755 µM 0.0450173333621675 0.483423158897417 no 1607 0.482046746467431 2326 3104697 SGTC_2370 9071495 200 µM 0.0439157863429818 0.483915526010737 no 1608 0.482485765879398 2190 21791103 SGTC_550 4123-0385 25.7 µM 0.0437597535390555 0.483985271217839 no 1609 0.482547954178049 2294 5731123 SGTC_1390 3413-2614 145 µM 0.0432289534165459 0.48422253757462 no 1610 0.482759512583474 2285 3421432 SGTC_3229 9132204 49.47 µM 0.0431860375437996 0.484241721110022 no 1611 0.482776617565617 2293 17682924 SGTC_1991 st073000 8.92 µM 0.042243229412285 0.48466316855108 no 1612 0.483152400605684 2303 4301969 YIL048W NEO1 SGTC_559 1550-0661 158 µM 0.0416674155351313 0.484920573266676 no 1613 0.483381915013572 2275 5830875 SGTC_325 2810-4341 181 µM 0.0406974340247846 0.485354195960108 no 1614 0.483768553627039 2333 774970 SGTC_160 3453-0671 289.699 µM 0.0385222782149779 0.486326644648289 no 1615 0.484635634609041 2327 5322268 SGTC_730 1436-0052 41.2 µM 0.0383111297191636 0.486421047401547 no 1616 0.48471980853463 2345 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1225 1216-0074 20.6 µM 0.0378643103907984 0.486620819145255 no 1617 0.484897934406743 2296 4241466 SGTC_1513 0337-0559 19 µM 0.0366956325874006 0.487143347657611 no 1618 0.485363845494926 2285 775073 SGTC_1548 st061468 90.8 µM 0.036643983091464 0.487166441222922 no 1619 0.485384436813645 2336 390799 SGTC_2786 7743617 45.45 µM 0.0357061709105908 0.487585763987837 no 1620 0.485758325008112 2299 583674 SGTC_3314 9135860 59.4275 µM 0.0355298034381509 0.48766462449818 no 1621 0.485828640832746 2323 25252478 SGTC_1227 3909-8010 46.6 µM 0.0342737206806991 0.488226279967267 no 1622 0.486329440206446 2294 15982272 SGTC_2827 7993847 71.43 µM 0.0334773585049898 0.488582384252498 no 1623 0.486646960502633 2311 2985692 SGTC_1121 fusaric acid 630.51 nM 0.033424213611815 0.488606149048582 no 1624 0.486668150388922 2296 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_2305 7443522 69.23 µM 0.0328187668996292 0.488876889423798 no 1625 0.486909556225837 2324 5415886 SGTC_1035 k081-0041 55.2 µM 0.0327380651733455 0.488912977573676 no 1626 0.486941734265462 2338 731709 SGTC_3316 9136639 10.545 µM 0.03209748191887 0.489199436407386 no 1627 0.487197155757396 2274 4903665 SGTC_596 1155-0152 116 µM 0.0320745154090384 0.489209706776478 no 1628 0.487206313354063 2349 280313 SGTC_1506 4226-2149 212 µM 0.0319704453702071 0.489256245835967 no 1629 0.487247810011051 2265 991114 SGTC_181 1447-1644 8.07 µM 0.0318264136428623 0.489320655595995 no 1630 0.487305241130961 2348 534600 SGTC_2819 7996655 46.38 µM 0.0317881038542112 0.489337787453697 no 1631 0.487320516796243 2341 6456960 SGTC_1968 st069590 43.6 µM 0.0304689945908335 0.489927695268027 no 1632 0.487846510313684 2343 6384066 SGTC_208 k072-0098 12.366 µM 0.0303824579671893 0.48996639537145 no 1633 0.487881017455892 2360 5948901 SGTC_2968 9090663 33.37 µM 0.0295200755509888 0.49035206711102 no 1634 0.48822490397176 2254 25236811 SGTC_1145 3546-0597 10.2 µM 0.0292398256026291 0.490477401501984 no 1635 0.488336659281908 2265 875334 SGTC_1174 0739-0097 51.1 µM 0.0289282145826 0.490616762407761 no 1636 0.488460921525731 2335 728447 SGTC_2013 4024628 200 µM 0.0282822923981971 0.490905639968631 no 1637 0.488718501785022 2326 5230760 SGTC_79 0052-0007 94.094 µM 0.0282565268277691 0.490917163275732 no 1638 0.488728776653994 2352 2801472 SGTC_2237 6667747 47.222 µM 0.0272645815902461 0.491360803201508 no 1639 0.48912435307834 2232 729940 YDL015C TSC13 SGTC_2923 7992654 58.14 µM 0.0263649760578544 0.491763154155801 no 1640 0.489483114744988 2347 2985126 SGTC_1149 3909-7961 23.3 µM 0.0261563844928713 0.491856448496954 no 1641 0.489566302050545 2290 735261 SGTC_259 usnic acid 108.925 µM 0.0258592177238814 0.491989359615177 no 1642 0.489684814350612 2354 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_3259 9138485 49.47 µM 0.0247611128176603 0.492480506758299 no 1643 0.490122754508346 2357 17646153 SGTC_1188 1403-0014 4.57 µM 0.0238800414847884 0.492874590015862 no 1644 0.490474147165642 2348 9614867 SGTC_132 0417-1715 25.805 µM 0.0237887452276094 0.492915425168742 no 1645 0.490510558758874 2365 6769098 SGTC_643 k048-0106 28.4 µM 0.0224966107600352 0.493493381140062 no 1646 0.491025907769406 2356 6763920 SGTC_2156 5649887 115 µM 0.0223034820958581 0.493579766436452 no 1647 0.49110293563173 2338 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_225 nsc-122657 1.016 µM 0.0220768729201541 0.493681127749004 no 1648 0.491193317357951 2355 275685 SGTC_1730 st033808 45.1 µM 0.0218768224765188 0.49377060979386 no 1649 0.491273106667277 2284 1045166 SGTC_2995 9067767 71.4286 µM 0.0216105236330447 0.493889725061803 no 1650 0.491379319423857 2339 11673567 SGTC_3015 9080845 49.47 µM 0.021506387555928 0.493936305197798 no 1651 0.491420854054831 2352 5296973 SGTC_604 1000-0114 314 µM 0.0208964346775694 0.494209139162404 no 1652 0.491664135359692 2365 1572745 SGTC_289 k017-0060 526 µM 0.0195341883609083 0.494818486091885 no 1653 0.492207481936697 2380 5512909 SGTC_2540 epiandrosterone 100 µM 0.0187278469577482 0.495179176765615 no 1654 0.492529106744088 2376 441302 A steroid. SGTC_3026 9090633 49.47 µM 0.0182787641589648 0.495380061117629 no 1655 0.492708234191655 2364 25236842 SGTC_1085 doxorubicin 7.67 µM 0.0180136866430238 0.495498636519664 no 1656 0.492813967410397 2374 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_612 0302-0167 22.4 µM 0.0172769617778493 0.495828192920436 no 1657 0.493107832349411 2351 235821 SGTC_1151 3909-8316 15.3 µM 0.0170238254030633 0.495941428144404 no 1658 0.493208804300916 2311 800431 SGTC_1872 amphotericin b 148 nM 0.0169088558332495 0.495992857467717 no 1659 0.493254663922274 2369 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_770 0389-1121 67.2 µM 0.0163428058247181 0.496246069502218 no 1660 0.49348045399208 2373 6753108 SGTC_1123 mangostin 811.285 nM 0.0161003538175713 0.496354526405864 no 1661 0.493577165623293 2328 5281650 An antioxidant. SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.0159532357347688 0.496420337383838 no 1662 0.493635849709454 2381 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_3109 9122853 49.47 µM 0.0154832782292939 0.496630566182213 no 1663 0.493823312467613 2319 1234709 SGTC_1615 st002656 86.5 µM 0.0140608942504072 0.497266854863415 no 1664 0.494390699618493 2381 1584458 SGTC_3129 9127257 49.47 µM 0.0138807476243481 0.497347442112873 no 1665 0.494462560710799 2358 837894 SGTC_1182 1222-0449 220 µM 0.013364192236079 0.497578519901659 no 1666 0.494668617373029 2369 658318 SGTC_1989 st071868 50.2 µM 0.0133117258352595 0.497601990461275 no 1667 0.494689546576867 2382 16414057 SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.0126927296051104 0.497878895669434 no 1668 0.494936469467523 2372 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_982 1491-0518 27.5 µM 0.0123806698550864 0.498018494605321 no 1669 0.495060953512423 2377 3091256 SGTC_408 cantharidin 100 µM 0.0117859989291516 0.498284519408647 no 1670 0.49529817556554 2364 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3114 9122766 49.47 µM 0.0107104747807416 0.498765654758533 no 1671 0.495727220458409 2349 17176985 SGTC_2148 5546263 113.568 µM 0.0105847927093366 0.498821878719618 no 1672 0.495777357508396 2377 792097 SGTC_2774 tamoxifen 10.92 µM 0.0105060251033239 0.498857115474341 no 1673 0.495808779489553 2389 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_2493 resveratrol 26.09 µM 0.00967484708269429 0.499228944150257 no 1674 0.496140354654571 2383 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_336 4111-0029 111 µM 0.0091658308224783 0.499456653653342 no 1675 0.496343413749776 2354 3131175 SGTC_2844 9010103 25.97 µM 0.00840038531964079 0.499799077631519 no 1676 0.496648770538452 2372 2480525 SGTC_1150 3909-7983 10.9 µM 0.0082700821918514 0.4998573690864 no 1677 0.496700752159587 2382 23965914 SGTC_3083 9117465 49.47 µM 0.00799275950505638 0.499981430145232 no 1678 0.496811384246752 2368 16420915 SGTC_2261 9010538 184.68 µM 0.0079097384194355 0.499981430145232 no 1679 0.496844503820996 2352 6457250 SGTC_948 3448-0295 75.3 µM 0.00785411992993753 0.499956549062028 no 1680 0.496866691698807 2401 678569 SGTC_1628 st004252 77.7 µM 0.00613216184073139 0.499186226968945 no 1681 0.497553636703411 2393 692968 SGTC_2122 5258151 111.688 µM 0.00413964210190912 0.498294872445479 no 1682 0.498348526456604 2390 2173356 SGTC_2556 citropten 84.59 µM 0.00387960563371423 0.498178545557436 no 1683 0.498452265164009 2389 2775 A potential DNA crosslinker. SGTC_2568 diosmetin 100 µM 0.00367737520808549 0.498088078214382 no 1684 0.498532942855119 2400 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_3207 9114163 49.47 µM 0.00351867945995006 0.498017086083662 no 1685 0.498596252888903 2401 849233 SGTC_756 0508-1999 28.3 µM 0.00304696318345462 0.497806065412101 no 1686 0.498784439440168 2396 6753853 SGTC_1822 st052468 42 µM 0.00286886287337926 0.497726393000716 no 1687 0.498855490873092 2401 2873678 SGTC_2067 5224629 34.075 µM 0.0025752562806322 0.49759504954765 no 1688 0.498972622522372 2393 2835000 SGTC_2964 9083345 53.42 µM 0.00249667219805386 0.497559895391696 no 1689 0.499003972934662 2396 17741579 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.000656815012520628 0.49673685142409 no 1690 0.499737968739943 2405 688669 SGTC_1065 prochlorperazine maleate 2.48 µM 0 0.496443034173982 no 1691 0.5 2405 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_363 0455-0021 3.06 µM -0.000234859451645952 0.496337973457072 no 1692 0.499906304635648 2406 4597466 SGTC_2384 9036245 200 µM -0.000238967003960023 0.496336136009773 no 1693 0.499904665959407 2407 6462766 SGTC_746 1095-0025 46.6 µM -0.000420038408434113 0.496255136714299 no 1694 0.499832428924411 2406 6749286 SGTC_2388 9080168 200 µM -0.000578310568100163 0.496184336409923 no 1695 0.499769287476042 2408 15943073 SGTC_2685 mycophenolic acid 18.85 µM -0.00176556291964733 0.495653243657227 no 1696 0.499295642668582 2412 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2541 muurolladie-3-one 83.07 µM -0.00438275182120364 0.49448252694565 no 1697 0.498251540591568 2435 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_720 r052-1644 49.9 µM -0.00467648742147319 0.494351136391097 no 1698 0.498134358243931 2420 1422863 YOR257W CDC31 SGTC_3012 9080433 71.4286 µM -0.0047208183854496 0.494331306808285 no 1699 0.498116672943294 2414 17688859 SGTC_1656 st012921 11 µM -0.00557107842920481 0.493950981687362 no 1700 0.497777472763895 2418 6732821 SGTC_1795 st049545 62.3 µM -0.0056604952286175 0.493910985466538 no 1701 0.497741801184536 2416 5291882 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.00667192415147073 0.493458576689842 no 1702 0.497338307111715 2401 2724 A muscle relaxant with antifungal properties. SGTC_92 0063-0024 660.874 µM -0.00731212002253981 0.493172223527833 no 1703 0.497082912158366 2411 3594437 SGTC_2107 5363541 170.161 µM -0.0079041868943358 0.492907401110484 no 1704 0.496846718489848 2420 244052 SGTC_1661 st013063 9.66 µM -0.00833767593359773 0.492713510097396 no 1705 0.496673787087816 2420 721395 SGTC_3335 9143315 29.6265 µM -0.00835254479020537 0.492706859584266 no 1706 0.496667855478798 2429 4899691 SGTC_2937 9044753 11.33 µM -0.00886700781458422 0.492476752829263 no 1707 0.496462622035872 2420 6465530 YGL099W LSG1 SGTC_1274 0865-0114 173 µM -0.0104058766901054 0.491788469585552 no 1708 0.495848730741951 2432 870624 SGTC_742 0kpi-0133 140 µM -0.0109259977107984 0.491555842726103 no 1709 0.495641244280606 2428 2728852 SGTC_2083 5306046 65.942 µM -0.0114420163743636 0.491325053505313 no 1710 0.49543539549491 2432 539837 SGTC_1237 0330-0133 46.1 µM -0.0123612145035544 0.490913949611258 no 1711 0.495068714480836 2425 X1237 YHR072W ERG7 SGTC_2580 diallyl disulphide 81.36 µM -0.0124243794909642 0.490885699933333 no 1712 0.49504351723171 2440 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_26 0302-0163 425.158 µM -0.0128642510667579 0.490688974654262 no 1713 0.49486804789106 2429 3100915 SGTC_1610 st001799 48.1 µM -0.0137207676239489 0.490305918348119 no 1714 0.494526377419325 2431 621897 SGTC_737 1950-0117 57.9 µM -0.0138319705224247 0.490256186190648 no 1715 0.494482018091084 2428 5393513 SGTC_2431 5490079 200 µM -0.0140411876692055 0.490162620514712 no 1716 0.494398560630892 2442 5722345 SGTC_2127 5253358 187.912 µM -0.0141152473510367 0.490129499820682 no 1717 0.494369018020305 2437 20612 SGTC_205 1486-1330 71.903 µM -0.014221132756703 0.490082146263694 no 1718 0.494326780094709 2419 4118834 SGTC_1574 spiramycin 23.7 µM -0.0143066409484429 0.490043905807371 no 1719 0.49429267073181 2424 6419898 An antibiotic and protein synthesis inhibitor. SGTC_93 0109-0045 59.227 µM -0.0147840221995154 0.489830415943174 no 1720 0.494102243313807 2429 88733 SGTC_2917 7979103 53.79 µM -0.0157839843436886 0.489383231980027 no 1721 0.493703362744435 2436 2980565 SGTC_2048 5246248 200 µM -0.0160113103463506 0.489281573430415 no 1722 0.493612684250281 2443 677046 SGTC_2696 st077691 74.316 µM -0.0161311534498985 0.489227980738335 no 1723 0.493564879943244 2461 757133 SGTC_2246 7293507 91.5585 µM -0.0169484954627745 0.488862478427683 no 1724 0.493238852263893 2429 887656 SGTC_2644 guaiazulene 100 µM -0.0170483793410878 0.488817812585758 no 1725 0.493199010118268 2437 3515 A coloring agent. SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.0172475709085199 0.488728738980125 no 1726 0.493119555862993 2457 616764 SGTC_1496 4469-0713 57.4 µM -0.0176540265611799 0.488546983684745 no 1727 0.492957428207432 2441 746691 SGTC_696 1560-0013 611 µM -0.0184195821696127 0.488204655690761 no 1728 0.492652065390005 2456 1650269 SGTC_1388 3346-4487 254 µM -0.0185799622956721 0.488132940756103 no 1729 0.492588093924637 2456 3345614 SGTC_3141 9094609 49.47 µM -0.0201782031760297 0.487418299109497 no 1730 0.491950607845853 2451 25236309 YDL196W YDL196W SGTC_511 blebbistatin 171 µM -0.0204793244474873 0.487283659402431 no 1731 0.491830502659411 2463 3476986 A myosin inhibitor. SGTC_869 0564-0080 44.1 µM -0.0209399110387499 0.487077721118728 no 1732 0.491646794595335 2478 6843321 SGTC_2726 cimetidine 79.27 µM -0.0209678847192842 0.487065213588116 no 1733 0.491635637161124 2442 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_2924 9010168 62.78 µM -0.0217500276891486 0.486715508736669 no 1734 0.49132367843576 2464 2993929 SGTC_2490 carminic acid 95.39 µM -0.0229523222837768 0.486177969417926 no 1735 0.490844152111987 2442 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_1376 2910-0861 41.3 µM -0.0231572217280453 0.486086362477967 no 1736 0.49076243078183 2458 1112859 SGTC_1648 st011736 69.8 µM -0.023260004853174 0.486040410225595 no 1737 0.490721437289371 2456 2855514 SGTC_3007 9078383 71.4286 µM -0.023750307489543 0.48582120841437 no 1738 0.490525888866457 2467 6496995 SGTC_2236 dapsone 200 µM -0.0241625761642012 0.485636896911321 no 1739 0.490361464651627 2450 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.0242365704846365 0.485603816854963 no 1740 0.490331953831021 2457 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2744 captopril 92.04 µM -0.0247129610347627 0.485390843076717 no 1741 0.490141958413883 2461 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1276 0871-0068 94.2 µM -0.0247793291804988 0.485361173055219 no 1742 0.490115489460142 2476 3414906 SGTC_1745 st081495 74 µM -0.0255734462171458 0.485006167668285 no 1743 0.489798782995138 2468 13842402 YBL026W LSM2 SGTC_2499 avocadenofuran 51.48 µM -0.0267571842888998 0.484477006616821 no 1744 0.48932670148371 2455 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_206 4546-0025 72.014 µM -0.0268397928831233 0.484440079481965 no 1745 0.48929375725448 2462 6620745 YIL048W NEO1 SGTC_2360 9040895 200 µM -0.0268981308578701 0.48441400171559 no 1746 0.489270492169331 2466 4914414 SGTC_2411 st077133 39.94 µM -0.0278883961971139 0.483971351628868 no 1747 0.48887558166924 2600 1403142 YNL221C POP1 SGTC_2831 7999036 19.48 µM -0.0282041843248759 0.483830197991786 no 1748 0.488749649972274 2482 2988270 SGTC_2999 9069765 71.4286 µM -0.0293574878542872 0.483314702014271 no 1749 0.488289738977723 2472 2097066 SGTC_1138 3761-0006 1.03 µM -0.029498929803425 0.483251483130729 no 1750 0.488233336232263 2442 12061087 SGTC_2352 9027995 87.8 µM -0.0299065582619852 0.483069291904804 no 1751 0.488070787726844 2481 2997347 SGTC_784 4579-0127 173 µM -0.0303993217305245 0.482849053957412 no 1752 0.487874292893831 2541 1948547 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.0318990686936655 0.482178782707525 no 1753 0.487276270668953 2456 688798 SGTC_154 3389-1638 511.116 µM -0.0324943431461421 0.481912754786122 no 1754 0.487038913582295 2510 5238686 SGTC_3003 9075612 71.4286 µM -0.0326802929913079 0.481829655517853 no 1755 0.48696476970551 2497 6501993 SGTC_2334 9017922 200 µM -0.0333652828504374 0.481523546715172 no 1756 0.486691647255634 2505 3163164 SGTC_941 3237-0776 460 µM -0.0334552392951989 0.481483347714287 no 1757 0.486655779850439 2481 760008 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.0337203293113177 0.481364887550727 no 1758 0.486550083871916 2501 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3070 9117005 49.47 µM -0.0350009944914976 0.480792623022051 no 1759 0.486039473935474 2462 8779016 SGTC_2978 9011784 42.97 µM -0.0357595503566718 0.480453681342319 no 1760 0.485737043281158 2538 2994934 SGTC_346 4513-0042 7.16 µM -0.035822317692754 0.480425635960741 no 1761 0.485712018770191 2474 2827372 SGTC_2055 5235184 200 µM -0.0359087409832374 0.480387020904619 no 1762 0.485677563033575 2501 2836034 SGTC_2161 5662504 8.5105 µM -0.0360604532796393 0.480319234312389 no 1763 0.485617077757748 2499 2859334 SGTC_830 4076-0286 57.8 µM -0.0374085979649496 0.479716894823418 no 1764 0.485079608642949 2487 6866659 SGTC_2652 actinonin 100 µM -0.0388270532043469 0.47908319120755 no 1765 0.484514137877367 2476 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_67 0335-0847 266 µM -0.0389274516988737 0.479038339546404 no 1766 0.484474114930617 2577 4552207 YOR254C SEC63 SGTC_352 k048-0007 5.11 µM -0.0401839196992794 0.478477052197316 no 1767 0.483973248748223 2473 6811911 SGTC_735 3076-0345 636 µM -0.0410860731021976 0.478074069952771 no 1768 0.483613638641799 2495 2888990 SGTC_1497 4476-2978 41.3 µM -0.0417654304653864 0.477770623082 no 1769 0.483342846723083 2540 1528379 SGTC_1507 4075-3230 155 µM -0.0419213774479189 0.477700968441852 no 1770 0.483280687318671 2455 659771 SGTC_2883 9059145 45.46 µM -0.0432577443476694 0.47710410042837 no 1771 0.482748037397999 2476 16476510 SGTC_99 0109-0120 622.8 µM -0.0439323231771755 0.476802829444312 no 1772 0.482479174998089 2489 759414 SGTC_98 0074-0023 107.663 µM -0.0443671566692707 0.476608637194424 no 1773 0.48230587051936 2529 3563821 SGTC_233 rapamycin 362 pM -0.0444549961359661 0.476569409647869 no 1774 0.482270862183483 2497 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1440 4100-1550 40 µM -0.0448035517164114 0.476413753154812 no 1775 0.48213194703864 2482 742806 SGTC_2697 mebhydrolin 72.4 µM -0.0449774364037704 0.476336101802587 no 1776 0.48206264694548 2502 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_817 1391-0715 46 µM -0.0463007230965001 0.475745193848714 no 1777 0.481535281490699 2513 1353946 SGTC_53 0973-0023 39.979 µM -0.0478855441412291 0.475037569166991 no 1778 0.480903730139218 2475 674768 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.0504771043681258 0.473880604772056 no 1779 0.479871097104384 2502 641818 YHR062C RPP1 SGTC_2072 5231554 129 µM -0.0508625417372707 0.473708550440962 no 1780 0.479717527109106 2522 789545 SGTC_753 1322-0200 289 µM -0.0513211109261468 0.473503857388182 no 1781 0.479534823091434 2563 5403907 SGTC_580 1123-0028 41 µM -0.0523809800778828 0.473030786932464 no 1782 0.479112564504177 2502 1677248 YPR107C YTH1 SGTC_2475 5812728 15.03 µM -0.0532054872557616 0.472662796088217 no 1783 0.478784091806135 2481 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_299 1273-0059 1.44 µM -0.0532187769042026 0.472656864894115 no 1784 0.478778797504279 2516 2848077 SGTC_3300 9124615 50.48 µM -0.0536218656955939 0.472476968525333 no 1785 0.478618217633123 2581 24824903 SGTC_1041 0206-0046 107 µM -0.0548469814252355 0.471930240551278 no 1786 0.478130185470944 2602 50494 SGTC_2151 5563267 85.4165 µM -0.0550268444980512 0.47184997813477 no 1787 0.478058538685535 2535 5310824 SGTC_42 0133-0086 60.653 µM -0.0560589801600351 0.471389418288918 no 1788 0.477647410806296 2520 162923 Model of phenazepam hydroxylation. SGTC_1190 1486-1332 13 µM -0.0576427149529453 0.470682798339261 no 1789 0.477016612302716 2505 4150046 SGTC_52 0329-0193 875 nM -0.0582234782978251 0.470423700336359 no 1790 0.476785309732544 2682 3739292 SGTC_2903 5923464 63.88 µM -0.0585615029852269 0.470272901945792 no 1791 0.476650687099559 2512 2876576 SGTC_312 4092-0653 6.84 µM -0.0588188115310558 0.470158115214339 no 1792 0.476548212482549 2598 1148278 SGTC_1749 st037932 54.2 µM -0.0588822850011778 0.47012979973757 no 1793 0.476522934044069 2589 594497 SGTC_3240 9133527 49.47 µM -0.0595377539400365 0.469837404298162 no 1794 0.476261897750777 2495 17617455 SGTC_2809 7964133 12.99 µM -0.0606885541147573 0.469324088026842 no 1795 0.475803623686084 2539 1253665 SGTC_2337 9009472 200 µM -0.0608225315113596 0.469264330490261 no 1796 0.475750272993919 2530 5742383 SGTC_1372 2752-0194 270 µM -0.0632443826913107 0.468184240158416 no 1797 0.474785951609319 2527 823334 SGTC_2566 crystal violet carbinol 226 nM -0.0635933415606469 0.468028631583488 no 1798 0.474647016838534 2648 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2868 9035608 32.47 µM -0.0644813042060407 0.467632691238632 no 1799 0.47429349660521 2492 6462614 SGTC_219 mitoxanthrone 164.414 µM -0.0654979244815311 0.467179422113367 no 1800 0.473888779406603 2582 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2864 9034755 47.6 µM -0.0658096333006409 0.467040452481793 no 1801 0.473764693299916 2524 4930451 SGTC_1636 st007707 68.9 µM -0.0659592929675737 0.466973730904341 no 1802 0.473705117174486 2554 403051 SGTC_2457 5731572 11.68 µM -0.0662152728403901 0.466859611588337 no 1803 0.473603218745879 2521 2865357 SGTC_2260 7964312 200 µM -0.0667190715708296 0.466635019213945 no 1804 0.47340267561149 2700 231951 SGTC_699 0375-0592 111 µM -0.0672547389695847 0.46639623151125 no 1805 0.473189454165984 2514 762578 SGTC_2027 5150920 200 µM -0.0675618391251679 0.46625933906328 no 1806 0.473067216961236 2593 786715 SGTC_1357 1503-1303 39.5 µM -0.067949257179831 0.466086649940084 no 1807 0.472913013885397 2526 292895 SGTC_1755 st041960 45.185 µM -0.0685438448929095 0.465821628695616 no 1808 0.472676359472759 2603 2257073 SGTC_1134 3477-0009 42.5 µM -0.0688976247529614 0.465663948163486 no 1809 0.472535554600485 2593 3973534 SGTC_1920 st075728 45.7 µM -0.0689236941916875 0.46565232916506 no 1810 0.472525179063468 2536 3400306 SGTC_1824 st053723 68.6 µM -0.0694851952383262 0.465402078511594 no 1811 0.472301708328817 2560 675225 SGTC_2177 5811945 192 µM -0.0697425029587736 0.465287405774842 no 1812 0.472199305826959 2595 5343475 SGTC_3306 9127676 59.7925 µM -0.0699648702797315 0.465188307030961 no 1813 0.472110810273316 2575 41905287 SGTC_3181 9108277 49.47 µM -0.0701215653083681 0.465118476661181 no 1814 0.472048451157643 2538 17097298 SGTC_1498 4478-3555 97.6 µM -0.0705412622154817 0.464931446093724 no 1815 0.471881429914856 2511 3437919 SGTC_1304 1165-0502 251 µM -0.0718114461201015 0.464365458280801 no 1816 0.471375981826781 2561 767425 SGTC_826 1683-5028 118 µM -0.0722047861966802 0.464190202409783 no 1817 0.471219468142059 2591 722377 SGTC_2414 st077232 92.9 µM -0.0733243007053201 0.46369143175537 no 1818 0.470774027289648 2540 729801 SGTC_3032 9089427 49.47 µM -0.0741958913015165 0.46330315663633 no 1819 0.470427257554114 2609 17173707 SGTC_2470 5664817 21.68 µM -0.0747048034150757 0.463076463226475 no 1820 0.470224792891506 2535 2859561 SGTC_621 3584-0052 32.1 µM -0.0750431368904262 0.462925760202031 no 1821 0.470090195178111 2540 2273927 SGTC_152 4469-0003 551.229 µM -0.0754402058823969 0.462748901553227 no 1822 0.4699322353332 2543 697280 SGTC_2863 9028737 58.44 µM -0.0759174455387856 0.462536343805483 no 1823 0.469742388690219 2659 6460917 SGTC_836 0330-0104 1.35 µM -0.0768400683984862 0.462125447238482 no 1824 0.46937538748847 2549 46494820 SGTC_757 1066-0008 322 µM -0.077452318852226 0.461852799483697 no 1825 0.469131860658628 2694 6842497 SGTC_35 0133-0054 64.071 µM -0.0793536772593249 0.461006200212581 no 1826 0.468375656294295 2571 99677 SGTC_3156 9099931 49.47 µM -0.0806529278037943 0.460427797013009 no 1827 0.467858986484007 2566 18111053 SGTC_890 0929-0006 47.2 µM -0.0819729983024297 0.459840210889894 no 1828 0.467334092704223 2548 1378169 SGTC_3142 9086498 49.47 µM -0.0822024731608458 0.459738076588502 no 1829 0.467242853402833 2563 25236367 SGTC_1520 flindersine 88 µM -0.0823630083125183 0.459666627440123 no 1830 0.467179025581067 2783 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2121 5257820 149.641 µM -0.0825430178905156 0.459586512386192 no 1831 0.467107455846978 2573 791256 SGTC_2435 5706476 10.6 µM -0.0831237121797322 0.459328079816046 no 1832 0.466876585748596 2577 5725375 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.0835792052336851 0.459125378907828 no 1833 0.466695500448286 2686 165506 SGTC_3178 9107506 49.47 µM -0.0836186166650712 0.459107840757254 no 1834 0.466679832407974 2632 8897194 SGTC_3319 9138450 16.7555 µM -0.0836445636899684 0.459096294332742 no 1835 0.46666951717945 2580 2029690 SGTC_1570 verbenone 133 µM -0.0837379573106889 0.459054734462855 no 1836 0.466632388771291 2604 29025 A natural terpanoid with antifungal properties. SGTC_666 0272-0154 136 µM -0.0838493718774505 0.459005155913577 no 1837 0.466588096559435 2578 6870312 SGTC_1377 2944-0135 198 µM -0.0851314860702321 0.458434671913314 no 1838 0.466078429447991 2619 1894137 SGTC_937 3122-0005 46.7 µM -0.0861028781329806 0.458002502426477 no 1839 0.465692317852269 2560 759535 SGTC_2591 skatole 100 µM -0.0870996160955832 0.457559108233181 no 1840 0.465296165269426 2629 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_2641 levomentholum 100 µM -0.0872428217071729 0.457495408217195 no 1841 0.465239251147657 2561 16666 SGTC_750 4073-0104 132 µM -0.0874257297977626 0.457414049527894 no 1842 0.465166559127318 2579 22330957 SGTC_692 k241-0027 77.8 µM -0.087498952752637 0.457381479988981 no 1843 0.465137458911255 2639 3600480 SGTC_2346 9031566 143.75 µM -0.0879749369728417 0.457169769399542 no 1844 0.464948298143877 2657 4771086 SGTC_2807 7945238 51.95 µM -0.0884593333955601 0.456954329668581 no 1845 0.464755802417604 2641 17148797 SGTC_2058 5236698 133 µM -0.0885103720106673 0.456931630514203 no 1846 0.464735520511021 2596 766665 SGTC_3233 9132340 49.47 µM -0.0898257536403807 0.456346670172852 no 1847 0.464212841234065 2564 17682950 SGTC_1082 camptothecin 424.86 nM -0.091178315904489 0.455745273971004 no 1848 0.463675452287284 2522 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1203 3992-3522 103 µM -0.0913080447572757 0.455687597319959 no 1849 0.463623912950787 2699 5322312 SGTC_272 doxorubicin 8.13 µM -0.0919944203511802 0.455382454517251 no 1850 0.463351236354495 2546 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1902 st060212 70.5 µM -0.0921957163557567 0.455292969099879 no 1851 0.463271270702001 2572 688944 SGTC_2279 7948423 32.93 µM -0.0931802377584499 0.454855336400044 no 1852 0.462880187029323 2560 1247112 SGTC_2518 prenyletin 46.28 µM -0.0940065654648257 0.454488065144176 no 1853 0.462551970674276 2598 3873459 A coumarin with calcium channel inhibitory activity. SGTC_3307 9126885 69.2785 µM -0.0953702009761259 0.453882066218155 no 1854 0.462010392172286 2582 24824909 SGTC_104 0074-0074 590.992 µM -0.0954655758966883 0.453839685652555 no 1855 0.461972515900703 2559 3943124 SGTC_1511 0906-3109 28.5 µM -0.0959389878707121 0.453629329258783 no 1856 0.461784514768608 2561 2882180 SGTC_274 sirtinol 40.1 µM -0.0961616024892345 0.453530416929237 no 1857 0.46169611310898 2613 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_1619 st003326 88.7 µM -0.0971744914775895 0.453080405660303 no 1858 0.461293912504599 2651 2849032 SGTC_919 tnp00227 403.569 nM -0.0985126956522778 0.452485954246019 no 1859 0.460762595661586 2627 1269246 A methoxyflavone. YNL221C POP1 SGTC_1846 st056244 14.8 µM -0.0989652959337626 0.452284926089489 no 1860 0.460582912314506 2655 5393182 SGTC_646 4092-0839 27.3 µM -0.0991445370459462 0.45220531725408 no 1861 0.460511755405677 2664 877796 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.0999573340157761 0.451844342648626 no 1862 0.460189099130225 2560 1241132 A phosphatase inhibitor. SGTC_2657 nystatin 74.44 µM -0.101283015227699 0.451255674458479 no 1863 0.459662899369938 2635 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2024 5144227 134 µM -0.101838188894221 0.451009181590166 no 1864 0.459442556429331 2685 3475211 SGTC_3161 9100388 49.47 µM -0.10242599076028 0.450748222641534 no 1865 0.459209277257364 2597 25236368 SGTC_564 3555-0129 330 µM -0.102716553827813 0.450619232892773 no 1866 0.459093967542265 2585 563260 SGTC_695 3505-6186 243 µM -0.103190721425212 0.450408746736696 no 1867 0.458905801914828 2682 1819379 SGTC_427 1354-0053 47.3 µM -0.103355636628541 0.450335543045112 no 1868 0.458840360179257 2843 6813657 SGTC_2459 5811157 9.22 µM -0.104241120179325 0.449942517486315 no 1869 0.458489001259765 2572 2870684 YBR192W RIM2 SGTC_1780 st038448 24.544 µM -0.10441270136043 0.449866366131255 no 1870 0.458420921774245 2793 728868 YDL195W SEC31 SGTC_1118 chelidonine 707.474 nM -0.105252003049068 0.449493892953564 no 1871 0.458087923685727 2599 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_980 1473-0395 201 µM -0.106778447017316 0.448816587608841 no 1872 0.457482373245893 2597 768876 SGTC_3079 9117512 49.47 µM -0.107271652864735 0.448597776799078 no 1873 0.457286736245472 2567 7185044 SGTC_933 2914-0560 114 µM -0.10731728076081 0.44857753476882 no 1874 0.457268637824399 2629 463887 SGTC_2011 4012611 177 µM -0.10976129024552 0.447493489011062 no 1875 0.456299345702648 2604 2049887 SGTC_1708 st033234 31.827 µM -0.112317875362014 0.446359929802371 no 1876 0.45528568449715 2701 674664 SGTC_293 4049-0273 38.5 µM -0.113309211948489 0.445920500431625 no 1877 0.454892707099261 2618 1380311 SGTC_563 tetrahydrosecaminediol 614 µM -0.114365275875628 0.445452452474303 no 1878 0.454474119593714 2702 334274 A psychoactive constituent of the cannabis plant. SGTC_887 0885-0007 9.62 µM -0.115000283549961 0.445171053373022 no 1879 0.454222448647662 2761 5719458 SGTC_831 k061-1017 217 µM -0.115565495225213 0.444920607101255 no 1880 0.453998455224887 2686 1240153 SGTC_1461 k072-0203 53.8 µM -0.115865130418155 0.444787847138739 no 1881 0.453879715708321 2578 5418714 SGTC_715 0868-0130 184 µM -0.117798613340081 0.443931324563751 no 1882 0.453113614146414 2685 2876258 SGTC_2057 5236571 38.335 µM -0.118414066989284 0.443658736640936 no 1883 0.452869790175489 2681 54684039 YBR257W POP4 SGTC_2564 betulinic acid 100 µM -0.118815119948904 0.443481122339724 no 1884 0.452710914777149 2740 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_370 0180-0345 38.7 µM -0.119735871711464 0.443073392073229 no 1885 0.452346191624604 2587 3989527 SGTC_1688 st021091 57.6 µM -0.121005135983186 0.442511431269522 no 1886 0.45184348358193 2598 3656366 SGTC_648 0375-0473 33.3 µM -0.121146281039959 0.442448947082356 no 1887 0.451787586066338 2634 1713139 SGTC_854 0422-0053 192 µM -0.121424148803599 0.44232594064435 no 1888 0.451677545207356 2626 3596728 SGTC_2486 5283202 22.39 µM -0.121543222116091 0.442273230998803 no 1889 0.451630391072639 2690 1377751 SGTC_1913 st060213 96.1 µM -0.122466225306166 0.441864684078576 no 1890 0.451264896457499 2688 688959 SGTC_2165 5727197 32.143 µM -0.122667317724139 0.441775683161904 no 1891 0.451185272521457 3045 1361712 SGTC_3059 1327-0034 3 µM -0.124292701145232 0.441056417656501 no 1892 0.450541763066205 2663 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_650 1328-0195 38 µM -0.125360035167028 0.44058420604054 no 1893 0.450119262892095 2618 2780821 SGTC_1247 0448-0043 5.84 µM -0.126816569184239 0.4399399403749 no 1894 0.449542790654687 2730 3089013 YGL099W LSG1 SGTC_1606 st000094 49.2 µM -0.126852192529586 0.439924185159665 no 1895 0.449528692848752 2618 1242210 SGTC_74 000s-0487 160.283 µM -0.127999379631988 0.439416867196797 no 1896 0.449074731992563 2615 677548 SGTC_754 3474-0146 171 µM -0.128029147943578 0.439403704144198 no 1897 0.449062953065425 2617 24762078 SGTC_1291 0993-0025 5.79 µM -0.128536506972892 0.43917936872811 no 1898 0.448862204719781 2732 4353356 SGTC_1438 4092-1045 4 µM -0.128577251809597 0.439161353713189 no 1899 0.448846083649071 2636 1351342 SGTC_2215 7188065 200 µM -0.128840118517472 0.439045132258661 no 1900 0.448742080041087 2754 940217 SGTC_962 1254-0300 21.5 µM -0.129101515826114 0.438929565681455 no 1901 0.448638661295938 2628 7340576 SGTC_729 4092-0585 94.1 µM -0.129108006972856 0.43892669594148 no 1902 0.448636093195091 2619 2169061 SGTC_375 3970-0961 9.27 µM -0.129852528992176 0.438597563636407 no 1903 0.448341551285122 2699 2898222 SGTC_912 3474-0017 2.18 µM -0.129864329566359 0.438592347274721 no 1904 0.448336883064151 2781 3360550 SGTC_1658 st012944 20 µM -0.130428204100271 0.438343102910632 no 1905 0.448113826766031 2689 24207260 SGTC_1091 telmisartan 47.6 µM -0.130680018675664 0.43823180348248 no 1906 0.448014219782198 2737 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_502 l-744,832 89.3 µM -0.130933733395092 0.438119669151309 no 1907 0.447913864498284 2705 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_235 0330-0087 5 mM -0.134303512132826 0.436630802206502 no 1908 0.446581288062406 2652 46494818 YHR062C RPP1 SGTC_2792 7535235 81.82 µM -0.134628382257402 0.436487312156344 no 1909 0.446452850048902 2716 1281891 SGTC_2273 7815444 169.05 µM -0.134862956866256 0.436383709417096 no 1910 0.446360114028609 2726 2824616 SGTC_3287 9117173 37.0625 µM -0.134948782369979 0.436345804625876 no 1911 0.446326184764903 2645 2789709 SGTC_323 4013-0906 34.3 µM -0.135899205395646 0.435926089922476 no 1912 0.445950481825464 2762 2910086 SGTC_1094 duloxetine 25.4 µM -0.13601056420293 0.435876917661115 no 1913 0.445906464774225 2624 60834 A selective serotonin reuptake inhibitor. SGTC_2274 7947094 46.08 µM -0.136878265715701 0.435493804198589 no 1914 0.44556350928386 2635 2971028 SGTC_772 k072-0172 35.3 µM -0.136887249026501 0.435489838142209 no 1915 0.445559958879425 2678 5861980 SGTC_379 3970-0972 5.9 µM -0.137286592443877 0.435313537933825 no 1916 0.445402133884793 2707 2898042 YBL034C STU1 SGTC_1987 st072290 61.9 µM -0.137306924924434 0.435304561991927 no 1917 0.445394098491853 2692 54697379 SGTC_1906 st060206 94.7 µM -0.137640794827747 0.435157177129633 no 1918 0.445262156372427 2690 5133468 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.138765784131875 0.434660623794299 no 1919 0.444817616324438 2653 6708561 SGTC_2708 st078559 56 µM -0.139259997213531 0.434442518115543 no 1920 0.444622349700188 2661 17250902 SGTC_3274 9138298 49.47 µM -0.140796870934344 0.433764394155494 no 1921 0.444015207537062 2637 17015756 SGTC_1643 st009866 20.2 µM -0.142094165271323 0.433192132852994 no 1922 0.443502813426509 2691 3156273 YOR207C RET1 SGTC_142 0335-0849 62.6745 µM -0.145600949632181 0.431645927616854 no 1923 0.442118209138525 2683 3889043 YPR107C YTH1 SGTC_2639 lactacystin 53 µM -0.14570085764997 0.431601891571057 no 1924 0.442078772144355 2762 3870 A proteasome inhibitor. SGTC_489 paxilline 115 µM -0.146454916603085 0.431269555565804 no 1925 0.441781138716581 2725 105008 A toxic potassium channel blocker. SGTC_2709 st078560 56 µM -0.147927532232603 0.43062067094779 no 1926 0.441199979831041 2749 17250903 SGTC_2366 9070441 60.58 µM -0.14830076028034 0.4304562436319 no 1927 0.441052707688972 2692 6837235 SGTC_2691 st077356 60.2 µM -0.14841284895588 0.430406864808451 no 1928 0.441008480183138 2813 2839272 SGTC_3062 9077494 49.47 µM -0.148448014842737 0.430391373279292 no 1929 0.44099460471832 2754 16459633 SGTC_1360 1598-0022 39.8 µM -0.148916688346691 0.430184920097537 no 1930 0.440809686325214 2764 761525 SGTC_1466 k213-0079 57.5 µM -0.149586910580451 0.429889716797835 no 1931 0.440545267911687 2638 3657981 SGTC_487 nimodipine 119 µM -0.149961298794333 0.429724832370995 no 1932 0.440397574499784 2684 4497 L-type voltage-gated calcium channels inhibitor SGTC_1594 piperine 70.1 µM -0.150910017578931 0.429307061791068 no 1933 0.440023349053606 2681 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_400 oxethazaine 37.5 µM -0.150954503461546 0.429287474266039 no 1934 0.440005802753854 2733 4621 A local anesthetic. SGTC_953 1188-0045 9.7 µM -0.152481692783609 0.428615145290095 no 1935 0.439403514316878 2788 6144426 SGTC_3167 9103034 49.47 µM -0.15325325988311 0.428275549647314 no 1936 0.439099279188606 2662 5127859 SGTC_859 0439-0102 54.6 µM -0.153614706063539 0.428116481867438 no 1937 0.438956770407451 2663 610143 SGTC_220 paclitaxel 373.376 µM -0.153751043860229 0.428056484402359 no 1938 0.438903018032111 2791 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_505 gw-5074 63.9 µM -0.154855192239025 0.427570648963154 no 1939 0.43846773942161 2792 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2821 7996764 71.43 µM -0.15538754147287 0.427336449593494 no 1940 0.438257902668009 2841 2987135 SGTC_198 3454-2873 16.191 µM -0.157476443987906 0.426417715171584 no 1941 0.437434685614954 2696 710957 SGTC_1105 epirubicin 18.1 µM -0.157731578051861 0.426305530176847 no 1942 0.437334158137261 2677 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2511 berberine 10.47 µM -0.157786834596008 0.426281234108046 no 1943 0.437312386583103 2707 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1028 k015-0029 4.8 µM -0.159924303344549 0.425341613742488 no 1944 0.436470351806747 2673 4588309 SGTC_211 3455-0679 143.504 µM -0.159928912358406 0.425339588099589 no 1945 0.436468536440698 2748 748649 SGTC_2301 7769476 200 µM -0.160184144632545 0.425227417628098 no 1946 0.436368009432717 2774 977820 SGTC_2039 Aminomethylbenzodioxan 200 µM -0.160631599898663 0.425030782861323 no 1947 0.436191782477137 2685 15053 SGTC_203 k066-0004 30.888 µM -0.160720446522158 0.424991741321124 no 1948 0.436156792395979 2646 6795412 SGTC_1921 5740136 50 µM -0.160778737351046 0.424966127199363 no 1949 0.436133836242569 2705 1774243 SGTC_1826 st055655 41.6 µM -0.160991510353349 0.42487263330105 no 1950 0.436050043589288 2742 676168 SGTC_2379 9035213 200 µM -0.161813797327171 0.424511354603897 no 1951 0.435726243770461 2717 646551 SGTC_547 1120-0019 610 nM -0.162063718082656 0.424401562369542 no 1952 0.435627838607362 2666 3676939 SGTC_1876 myriocin 605 nM -0.164077672776978 0.423517030384773 no 1953 0.43483499906859 2800 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1097 itavastatin 7.23 µM -0.164882328078738 0.423163732013821 no 1954 0.434518301082518 2717 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1429 4049-0205 9.46 µM -0.165186093144119 0.423030374550415 no 1955 0.434398755480059 2683 22774478 SGTC_862 0452-0056 10.2 µM -0.167342537133967 0.422083917377507 no 1956 0.433550268100968 2691 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_1839 st053978 48 µM -0.16760886126916 0.421967059562548 no 1957 0.433445499771204 2699 3788398 SGTC_3061 glucosamine 200 µM -0.167620201036003 0.421962084047346 no 1958 0.433441038963323 2692 91431 and experimental redox chemotherapeutic SGTC_2585 alliin 100 µM -0.167880309210252 0.421847960591574 no 1959 0.433338720617616 2868 87310 A garlic compound which reacts with lipids. SGTC_2904 7225135 42.03 µM -0.168576641632627 0.421542474407084 no 1960 0.433064827430633 2805 4446116 SGTC_670 4204-0025 119 µM -0.168643517324442 0.421513138028506 no 1961 0.433038524448095 2819 719039 SGTC_723 4182-0001 115 µM -0.169410216508867 0.42117684104733 no 1962 0.432736994021356 2729 744821 YLR208W SEC13 SGTC_342 k048-0088 23.3 µM -0.169825817541484 0.420994570135224 no 1963 0.432573561193386 2670 6820570 SGTC_2081 5214970 32.255 µM -0.170917430519348 0.420515900161789 no 1964 0.432144345381237 2757 2063512 SGTC_2571 chrysanthemic acid 100 µM -0.172044763517659 0.420021690381248 no 1965 0.43170116871942 2774 2743 An insecticide. SGTC_218 alverine citrate 93.75 µM -0.173134416740222 0.419544118802316 no 1966 0.431272886394555 2821 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_2692 st077426 47.7 µM -0.173748552965687 0.419275008260234 no 1967 0.431031539029062 2829 25238571 SGTC_2576 guaiol 23.12 µM -0.173843490441662 0.419233410635629 no 1968 0.430994232160064 2883 227829 SGTC_2443 5493264 126.67 µM -0.173898074172061 0.41920949474042 no 1969 0.430972783079023 2861 5340055 SGTC_1799 st045822 46.1415 µM -0.174481965902642 0.418953680910096 no 1970 0.430743351249954 2773 3674992 SGTC_1724 st037281 8.293 µM -0.174893351935018 0.418773465602974 no 1971 0.430581717076024 2712 574124 YDL195W SEC31 SGTC_177 1327-0068 8.361 µM -0.175058622912754 0.418701070372713 no 1972 0.430516785139964 2691 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_976 1348-1067 47.6 µM -0.175437199496976 0.418535249224012 no 1973 0.430368056426065 2721 5310671 YGL099W LSG1 SGTC_558 k064-0027 21.3 µM -0.175667641452244 0.418434319930106 no 1974 0.430277529154529 2826 5088526 SGTC_3248 9135562 49.47 µM -0.176020842434074 0.418279634888839 no 1975 0.430138784099636 2762 17650701 SGTC_809 3998-0021 90 µM -0.176096816926294 0.418246363366417 no 1976 0.430108940787488 2776 715485 SGTC_1444 4112-3581 28 µM -0.17614036682511 0.418227291815506 no 1977 0.430091834262527 2721 2877249 SGTC_1821 st053465 65.6 µM -0.178480988575064 0.417202561077884 no 1978 0.429172625199979 2808 675086 SGTC_3199 9111318 49.47 µM -0.179897185349095 0.416582818688897 no 1979 0.428616642459882 2842 8548020 SGTC_3298 9116858 71.43 µM -0.180700914282699 0.416231190677944 no 1980 0.428301170553854 2858 2506942 SGTC_1368 1852-0141 284 µM -0.182221340957805 0.415566194003904 no 1981 0.427704512852146 2860 2838987 SGTC_654 1124-0271 80.9 µM -0.182775273576621 0.415323977684616 no 1982 0.427487175298645 2763 5403748 SGTC_587 k089-0003 57 µM -0.183984550707067 0.414795312910247 no 1983 0.427012787390303 2704 9659696 SGTC_506 n9-isopropylolomoucine 153 µM -0.184234201254749 0.41468619131031 no 1984 0.426914864977025 2826 6610355 SGTC_2712 st079126 47.7 µM -0.184298312884286 0.414658169347144 no 1985 0.426889718690932 2716 3152970 SGTC_1242 0402-0103 60.1 µM -0.184322213900373 0.414647722782723 no 1986 0.426880344152823 2722 432868 SGTC_789 1309-1135 70.6 µM -0.185874966482569 0.413969181316872 no 1987 0.426271406966446 2720 3092424 SGTC_1048 3161-0300 24.5 µM -0.187018746370271 0.413469522013703 no 1988 0.425822967390969 2733 2165101 SGTC_2324 6149169 200 µM -0.187453640979268 0.413279575378166 no 1989 0.425652484237255 2816 2888231 SGTC_2408 sulbentine 18.36 µM -0.187793970221419 0.413130945715202 no 1990 0.425519081370357 2835 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_199 4063-0024 41.6 µM -0.188495371506983 0.412824666819609 no 1991 0.425244171744888 2861 306215 SGTC_2911 7942208 15.64 µM -0.188707946501794 0.41273185277307 no 1992 0.425160861542864 2833 1243384 SGTC_1901 st060216 58.6 µM -0.189008149717783 0.412600786988292 no 1993 0.425043214684219 2739 688792 SGTC_2208 7283366 200 µM -0.189670354333359 0.412311709410634 no 1994 0.424783726448243 2773 898663 SGTC_3331 9141060 1.957 µM -0.189857754003368 0.412229910933727 no 1995 0.424710298849019 2753 4906567 YPR165W RHO1 SGTC_2945 9067681 61.76 µM -0.190484840286585 0.411956220465019 no 1996 0.424464610702702 2687 16456930 SGTC_404 fumagillin 50 µM -0.19151083830004 0.411508518227034 no 1997 0.424062694977938 2786 12015870 A methionine aminopeptidase binder. SGTC_2523 spermine 47.74 µM -0.191750861834141 0.411403798690694 no 1998 0.423968681584977 2856 1103 A DNA binding polyamine. SGTC_1756 st041558 35.5 µM -0.192506436318226 0.411074191381244 no 1999 0.423672763374268 2903 3955792 SGTC_1609 st001574 46.4 µM -0.192924982262191 0.410891634394064 no 2000 0.423508859773659 2749 3960012 SGTC_1141 3253-0389 52.6 µM -0.194341656212396 0.410273867818334 no 2001 0.42295418521015 2739 5402031 SGTC_2977 9011197 71.43 µM -0.194383626182791 0.4102555694328 no 2002 0.422937754906382 2980 2704722 SGTC_590 k048-0076 22.4 µM -0.194604223617889 0.410159394905775 no 2003 0.422851398153837 2863 6832814 SGTC_2417 cerulenin 830 nM -0.194638948768672 0.410144256169479 no 2004 0.422837804719366 2717 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1399 3562-5772 25 µM -0.196458209375695 0.409351321244679 no 2005 0.422125769661751 2713 23847490 SGTC_2756 carbadox 75.1 µM -0.196657074000436 0.409264667402823 no 2006 0.422047952007214 2789 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_1817 st052116 64.4 µM -0.196703605343 0.409244392342066 no 2007 0.422029744281244 2887 4361398 SGTC_2310 7668677 200 µM -0.19684770075561 0.409181607315555 no 2008 0.421973360767579 2944 2197143 SGTC_1199 1638-0010 4.46 µM -0.197429377530097 0.408928183726511 no 2009 0.421745771038401 2751 3111136 SGTC_3172 9105863 49.47 µM -0.197775503795451 0.408777402295622 no 2010 0.421610356363428 2797 2348785 SGTC_2432 5630864 12.22 µM -0.198544476935822 0.408442466322954 no 2011 0.42130954487233 2903 5714970 SGTC_1342 1486-1464 234 µM -0.198690316186852 0.408378951729817 no 2012 0.42125249978131 2766 3253938 SGTC_256 clotrimazole 625 nM -0.199411134226908 0.408065062945 no 2013 0.42097057576633 2747 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2032 5185112 25.99 µM -0.200116205004782 0.407758088561322 no 2014 0.42069484997092 2847 5718189 SGTC_1772 st048439 82.2 µM -0.200229244867389 0.407708878420618 no 2015 0.420650648086182 2830 2927068 YDL195W SEC31 SGTC_2353 9059630 146.67 µM -0.20058911254973 0.407552225339599 no 2016 0.420509935986464 2871 4779114 SGTC_41 0478-0632 82.643 µM -0.200640961012737 0.407529656535406 no 2017 0.420489663521464 2771 3750424 SGTC_2017 5132927 60.65 µM -0.201745318391009 0.40704902048974 no 2018 0.420057916004912 2772 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1715 st032160 10.2275 µM -0.202459534893677 0.406738255189489 no 2019 0.419778744894615 2865 5289825 SGTC_1993 st073995 70.8 µM -0.202541611818727 0.406702546162747 no 2020 0.419746665460492 2782 3098394 SGTC_381 3461-2219 42.7 µM -0.202574691787479 0.40668815435302 no 2021 0.419733736439294 2881 2883159 SGTC_2496 diffractaic acid 79.83 µM -0.20270346953465 0.406632129356813 no 2022 0.419683405589959 3032 94870 An apoptosis inducer which activates caspases. SGTC_1410 3909-8106 77.9 µM -0.205225588234858 0.405535263569362 no 2023 0.418697939191997 2834 1039210 SGTC_3175 9106517 49.47 µM -0.205418936148234 0.405451207327985 no 2024 0.41862241341043 2861 41468073 SGTC_1193 1488-0126 41.5 µM -0.205771248765842 0.405298053845587 no 2025 0.418484800370151 2791 1384710 SGTC_1741 st038134 10.228 µM -0.205991803973613 0.405202183879776 no 2026 0.418398656750239 2966 1272587 SGTC_1680 diphenhydramine 100 µM -0.206221017693093 0.405102556297737 no 2027 0.4183091354687 2829 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_3041 9091929 49.47 µM -0.206764112983117 0.40486652487044 no 2028 0.418097042086901 2925 25236887 SGTC_1853 st056710 91.2 µM -0.20747752007043 0.404556527841452 no 2029 0.417818473545677 2952 269167 SGTC_1988 st071872 53.4 µM -0.207603264352882 0.40450189433904 no 2030 0.417769377656917 2829 16414116 SGTC_115 0527-0192 112.043 µM -0.207608188482022 0.404499754936333 no 2031 0.417767455094607 2856 4233931 SGTC_2323 6148992 148.28 µM -0.207925883904866 0.404361730790895 no 2032 0.417643419196309 2832 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_1332 1480-0653 17.5 µM -0.208878654541401 0.403947866921061 no 2033 0.417271483910153 2807 5749438 SGTC_969 1313-0238 134 µM -0.209354912230171 0.403741030694253 no 2034 0.417085593814791 2777 5212874 SGTC_631 k072-0230 41.5 µM -0.210063728778227 0.403433245223881 no 2035 0.416808967045919 2886 5773147 SGTC_3121 9125696 49.47 µM -0.210905101193003 0.403067978392358 no 2036 0.416480661742081 2763 1235365 SGTC_910 3454-3003 490 µM -0.210986400455055 0.403032688242874 no 2037 0.416448941680083 2850 820824 SGTC_1655 st012546 55.1 µM -0.211656296548932 0.402741931768629 no 2038 0.416187592933463 2882 720985 YLR208W SEC13 SGTC_2090 5301565 104.445 µM -0.211786957110627 0.402685227140797 no 2039 0.416136622217511 2798 2056344 SGTC_1946 st076057 65.1 µM -0.21262553101065 0.402321348041789 no 2040 0.415809527951445 2771 953009 SGTC_3320 9137005 35.139 µM -0.213138890508576 0.402098629698705 no 2041 0.415609315629351 2828 4908713 SGTC_554 4483-2211 187 µM -0.214613457516137 0.401459073488199 no 2042 0.415034350414579 2890 747107 SGTC_1327 1436-0082 2.18 µM -0.214645835898588 0.401445033136911 no 2043 0.41502172742759 2808 15992205 SGTC_1126 isoteolin 1.0172 µM -0.214844744761305 0.401358782383235 no 2044 0.414944183045941 2803 133323 SGTC_313 3474-0040 5.03 µM -0.215513406751625 0.401068872789466 no 2045 0.414683530281269 2783 1043375 YIL048W NEO1 SGTC_1489 4065-0444 182 µM -0.216291009778789 0.400731798495143 no 2046 0.41438045818851 2864 2877968 SGTC_935 2996-0153 430 µM -0.218652692766814 0.399708513433229 no 2047 0.413460301456216 2961 23738523 SGTC_179 1273-0063 6.77 µM -0.218964051788133 0.399573657025151 no 2048 0.413339025380178 2803 3108139 SGTC_2858 9025781 8.96 µM -0.221124739671797 0.398638146671342 no 2049 0.412497653770953 2907 4894980 YPL153C RAD53 SGTC_106 0092-0003 11.579 µM -0.221138947555117 0.398631997022375 no 2050 0.412492122548804 2881 1072148 SGTC_1371 2421-0008 32.7 µM -0.221752463903749 0.39836647057474 no 2051 0.412253293202779 2838 2827552 SGTC_185 k048-0037 25.491 µM -0.225457456995796 0.396763974410886 no 2052 0.410811708886369 2924 6827589 SGTC_2197 6588183 93.1375 µM -0.225630418519066 0.396689206856252 no 2053 0.41074444014965 2813 884136 SGTC_3255 9139072 49.47 µM -0.225807010305276 0.396612873935426 no 2054 0.410675762228088 2886 17646060 SGTC_725 1497-0963 19 µM -0.225918217987029 0.39656480574188 no 2055 0.410632514099361 2932 3549977 SGTC_1257 0669-0121 16 µM -0.227460079252022 0.395898516899891 no 2056 0.410033003912232 2906 4307855 SGTC_3137 9097352 49.47 µM -0.228489534022048 0.395453824864015 no 2057 0.409632845795719 3112 44120435 SGTC_71 0417-1750 47.813 µM -0.229040879755806 0.395215716795332 no 2058 0.409418571537875 3026 6811472 SGTC_1669 st015249 58.4 µM -0.230541967185453 0.394567645037438 no 2059 0.408835328247922 2896 722793 SGTC_3277 9138724 49.47 µM -0.231216749242085 0.394276413030668 no 2060 0.40857320925569 2880 15943418 SGTC_1923 st058458 19.1 µM -0.232004778001438 0.393936379219614 no 2061 0.408267151369313 3064 3534982 SGTC_2598 perillyl alcohol 100 µM -0.232681478642675 0.393644447913209 no 2062 0.408004376205807 2973 10819 An apoptosis inducer. SGTC_2467 5474540 200 µM -0.233222515578496 0.393411085448747 no 2063 0.407794311482693 2808 5413519 SGTC_2351 9026858 72.31 µM -0.234875238251248 0.392698463174368 no 2064 0.407152784508055 2802 1409300 SGTC_2854 9024559 71.43 µM -0.235182531285738 0.392566003889645 no 2065 0.407033531902767 2913 3163529 SGTC_2847 9005661 71.43 µM -0.235203917546824 0.392556785761472 no 2066 0.407025232759813 2867 2991449 SGTC_652 0437-0092 114 µM -0.235715317723452 0.392336374715553 no 2067 0.406826791477581 2827 3091274 SGTC_1267 0828-0272 9.49 µM -0.240491715866316 0.390279446282827 no 2068 0.404974542316099 2968 745334 SGTC_1460 k062-0059 9.15 µM -0.240877309636378 0.390113525601203 no 2069 0.404825104352166 2732 1373085 SGTC_2932 9016711 44.54 µM -0.241563486889518 0.389818313615956 no 2070 0.404559208741965 2952 7117328 SGTC_83 0170-0301 39.027 µM -0.242166524362351 0.389558923068747 no 2071 0.404325566409833 2822 3089716 SGTC_1076 itraconazole 331 nM -0.242268004191663 0.389515277365959 no 2072 0.404286252164983 2818 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_1154 4088-0362 150 µM -0.242393705450704 0.389461216142651 no 2073 0.404237555649525 2805 6618304 SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.242572551225151 0.389384302371482 no 2074 0.404168273570629 2858 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_123 0083-0120 66.675 µM -0.242731823070842 0.389315810141396 no 2075 0.404106576658232 2837 16001701 SGTC_232 clozapine 119 µM -0.242762324483984 0.38930269390403 no 2076 0.404094761640506 2817 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_196 k015-0023 18.111 µM -0.245018481311552 0.388332850533214 no 2077 0.403221060712926 2819 5211998 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.24574950094945 0.38801875957345 no 2078 0.402938075366147 2852 6708514 SGTC_1705 st027868 56.3335 µM -0.245953503381973 0.387931120654444 no 2079 0.402859112957247 2922 292948 SGTC_470 aa-861 153 µM -0.246315609762331 0.387775574747173 no 2080 0.40271896364242 2857 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_3102 9121669 49.47 µM -0.247141604370337 0.387420829088841 no 2081 0.402399318265876 2860 41905072 SGTC_1591 genipin 88.4 µM -0.247261635402723 0.387369286338946 no 2082 0.402352873793418 2980 442424 A DNA cross-linking agent. SGTC_3351 9150312 21.596 µM -0.247626185053263 0.387212756567333 no 2083 0.40221182442286 2874 4904905 SGTC_1358 1509-0022 2.48 µM -0.249703837493831 0.386321008115814 no 2084 0.401408195153475 2908 3258434 SGTC_899 1083-0020 478 µM -0.250541970200418 0.385961443086522 no 2085 0.40108412592702 3028 767123 SGTC_3202 9113761 49.47 µM -0.251596912708184 0.385509004330592 no 2086 0.40067632259022 3028 4798415 SGTC_2005 4024620 188 µM -0.252357232304121 0.385183018596835 no 2087 0.400382477099461 2841 236743 SGTC_3241 9133421 49.47 µM -0.252694910278558 0.385038265739696 no 2088 0.400251990640713 2886 17018221 SGTC_2908 7930301 100 µM -0.25270269904214 0.3850349271092 no 2089 0.400248981016417 2855 2223178 SGTC_3169 9102970 49.47 µM -0.252809269991302 0.384989246642923 no 2090 0.400207801966693 2855 17027839 SGTC_669 0108-0021 26.2 µM -0.252915139205492 0.384943868548085 no 2091 0.400166895166095 2928 17201 SGTC_3134 9127454 49.47 µM -0.253254344863929 0.384798487449603 no 2092 0.400035836886789 2903 24262820 SGTC_2838 9002687 71.43 µM -0.25468455597071 0.384185687620131 no 2093 0.39948337276924 2829 6457060 SGTC_3352 9151559 45.5865 µM -0.255333296087433 0.38390781848831 no 2094 0.39923284271903 2949 17159339 SGTC_902 1120-0002 2.07 µM -0.255606052894331 0.383791008781753 no 2095 0.399127522052045 2838 3280475 SGTC_2171 5739187 198.077 µM -0.255757040560695 0.383726351965064 no 2096 0.39906922374274 2796 2262761 SGTC_2600 tangeritin 87.95 µM -0.256163668218941 0.383552239606738 no 2097 0.398912230693666 2830 68077 A bioactive flavone. SGTC_2718 lomofungin 53.02 µM -0.256222431570541 0.383527079893129 no 2098 0.398889544366495 3017 5351222 A RNA synthesis inhibitor. SGTC_2374 9071832 200 µM -0.256284522341665 0.383500496068008 no 2099 0.398865573818517 2825 17381698 SGTC_1668 st014914 51.6 µM -0.25670225223333 0.383321661554447 no 2100 0.398704316383603 2903 2839556 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.258506791551852 0.382549405586952 no 2101 0.398007904056957 2816 688667 SGTC_1003 4049-0218 100 µM -0.258594527004391 0.382511870911866 no 2102 0.397974053234019 3021 295161 SGTC_2605 digitonin 300 nM -0.259313111626739 0.382204490115843 no 2103 0.397696831857158 2965 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2767 sibutramine 71.45 µM -0.26219692951514 0.380971660486845 no 2104 0.396584810251265 3060 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_297 0986-0032 24 µM -0.264932542764651 0.379803303659294 no 2105 0.395530714148383 2849 2847425 SGTC_1969 st069479 40.1 µM -0.26507828850211 0.379741087580072 no 2106 0.395474576251398 3057 3895485 SGTC_419 nsc-638432 893 µM -0.26581323573753 0.379427400063289 no 2107 0.39519152459069 2948 368090 SGTC_2187 6125751 200 µM -0.265920829385191 0.379381483986452 no 2108 0.39515009147586 2905 874498 SGTC_1006 4099-6547 255 µM -0.266183583426376 0.37926935965994 no 2109 0.395048912805663 2974 3146833 SGTC_1251 0490-5699 265 µM -0.266349735430885 0.379198463301592 no 2110 0.394984936322967 3038 3883818 SGTC_66 0109-0187 42.4 µM -0.26659043417329 0.379095765371694 no 2111 0.39489226079634 2777 759417 SGTC_1219 1469-0211 33.1 µM -0.266634685365066 0.379076885828393 no 2112 0.394875223537503 2989 6822282 SGTC_1950 st077106 7.18 µM -0.267046899373115 0.378901030706961 no 2113 0.39471652568312 2968 13831864 SGTC_27 0485-0001 32.618 µM -0.267300371425632 0.378792909127484 no 2114 0.394618950405422 2851 2054479 SGTC_1843 st055809 45.5 µM -0.267641874872985 0.378647251688006 no 2115 0.394487497476165 3022 16413835 SGTC_1623 st003709 20.3 µM -0.267657847263482 0.378640439594369 no 2116 0.394481349611082 2868 16192618 SGTC_136 0097-0015 404.482 µM -0.267704313322972 0.378620622415248 no 2117 0.394463464706655 2883 4861337 SGTC_1959 st077091 55.8 µM -0.267728904023888 0.378610134925472 no 2118 0.394453999773376 2834 821356 YKL052C ASK1 SGTC_2614 arthonioic acid 13.39 µM -0.270304592982009 0.377512146559358 no 2119 0.393462966074421 2838 6710684 SGTC_2593 nobiletin 86.24 µM -0.270767452091137 0.377314939321732 no 2120 0.39328494725058 2971 72344 An anti-infammatory. SGTC_3192 9110362 49.47 µM -0.270964254395833 0.377231098789194 no 2121 0.39320926247648 2826 16649480 SGTC_2233 sulbentine 40.3845 µM -0.272894920429407 0.376408915479803 no 2122 0.392466995644617 2915 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_2387 9077560 195.08 µM -0.273343111256816 0.376218131300644 no 2123 0.392294739332141 2889 5303272 SGTC_1081 sertraline 6 µM -0.273628264766823 0.376096763969808 no 2124 0.392185155272824 3001 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_1627 st003713 25.6 µM -0.274943597464261 0.375537089498879 no 2125 0.391679785730524 2971 16195070 YER133W GLC7 SGTC_1785 bathophenanthroline 24 µM -0.275748333091129 0.375194803255276 no 2126 0.391370684895313 2913 72812 An iron chelator. SGTC_2038 4100038 30.985 µM -0.276339301120457 0.374943503471587 no 2127 0.391143736359131 2994 3596803 SGTC_2400 5203494 178.7 µM -0.277412804888134 0.374487148877746 no 2128 0.390731575225011 2844 6777674 SGTC_2348 9022543 33.42 µM -0.277447555106679 0.374472379229786 no 2129 0.390718235271235 3038 3162678 YDL140C RPO21 SGTC_1262 0737-0114 49.6 µM -0.277718063538153 0.374357413178335 no 2130 0.390614396582646 3046 765919 SGTC_1441 4106-0040 13 µM -0.278388008109033 0.374072734925172 no 2131 0.39035726198267 2894 2904180 SGTC_1165 k072-0275 30.3 µM -0.278819012236238 0.373889625459047 no 2132 0.39019186158818 2992 6153523 YGL055W OLE1 SGTC_3347 9188721 44.724 µM -0.282560817459442 0.372301142413155 no 2133 0.388756759927753 2969 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_1973 st070275 50.2 µM -0.282832479782612 0.372185899642268 no 2134 0.388652627586472 2895 17118334 SGTC_1330 1469-0054 61.8 µM -0.282868628675442 0.372170565663806 no 2135 0.388638771763579 3047 7102664 SGTC_480 am 92016 50 µM -0.2829402919112 0.372140167475501 no 2136 0.388611303758794 2965 2129 K+ channel blocker. SGTC_644 1498-1197 63.3 µM -0.282966823028263 0.372128913679865 no 2137 0.388601134712983 3012 6741615 SGTC_2656 pseudo-anisatin 100 µM -0.283209489764507 0.372025985960719 no 2138 0.388508127127083 2924 6708809 A neurotoxin. SGTC_938 3126-1755 342 µM -0.284110271189152 0.371643997229792 no 2139 0.38816293794934 3087 1777771 SGTC_930 2810-3379 265 µM -0.284688615447383 0.371398808984642 no 2140 0.387941356724429 3116 1015764 SGTC_1581 himbacine 57.9 µM -0.284934194350425 0.371294711925161 no 2141 0.387847279028884 2899 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2952 9073731 13.78 µM -0.285511703971544 0.371049951734316 no 2142 0.387626069468143 2935 16457353 SGTC_1032 k061-1018 98.7 µM -0.286716077262441 0.370539682015772 no 2143 0.387164863166357 3101 4005393 SGTC_258 haloperidol 50.781 µM -0.287228195875345 0.370322776177479 no 2144 0.386968799150539 2952 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_2846 9008642 19.48 µM -0.287363682071648 0.370265398421652 no 2145 0.38691693323969 3043 2992898 SGTC_1845 st056753 3.01 µM -0.28814517425602 0.369934496602797 no 2146 0.38661780712073 2849 5375839 SGTC_3049 9092223 49.47 µM -0.29036196906367 0.368996379128759 no 2147 0.385769667629971 3013 8623917 SGTC_78 0336-0123 156.75 µM -0.290924918285921 0.368758270605326 no 2148 0.385554371574802 2842 6765896 SGTC_1106 tegaserod maleate 11.7 µM -0.291658344920755 0.368448131461579 no 2149 0.385273930505614 2962 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_1725 st036284 20.55 µM -0.292343666429823 0.368158411638659 no 2150 0.385011937648704 3153 707914 SGTC_3332 9141069 11.198 µM -0.292975018431025 0.367891573773851 no 2151 0.384770623342273 2892 17332883 SGTC_497 capsazepine 133 µM -0.29351154251805 0.367664864560899 no 2152 0.384565589079076 2930 2733484 A calcium channel blocker. SGTC_101 0490-5701 117.494 µM -0.293995070347914 0.367460588506111 no 2153 0.384380835149778 2904 4661669 SGTC_2293 7624732 200 µM -0.294374747723869 0.367300212443575 no 2154 0.38423578044256 2871 894453 SGTC_2418 pentamidine 31.67 µM -0.294531922532515 0.367233828436804 no 2155 0.384175736978595 2999 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_2772 vinpocetine 57.06 µM -0.296878258172485 0.366243308079204 no 2156 0.383279727855224 3132 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1226 3909-7979 35.4 µM -0.298686694054458 0.365480472798581 no 2157 0.382589555236665 3039 6615510 SGTC_1 0258-0098 57.368 µM -0.298990278122232 0.365352466871045 no 2158 0.382473731698591 2986 6790032 YDR047W HEM12 SGTC_1558 st069300 45.6 µM -0.299738857867981 0.365036893059544 no 2159 0.382188178138596 3045 24208000 SGTC_2960 9079389 5.97 µM -0.300083143799832 0.364891785384491 no 2160 0.382056868174368 3104 16457355 SGTC_2604 4'-hydroxychalcone 11.32 µM -0.301025210721501 0.364494827344876 no 2161 0.381697635124953 3091 5282362 SGTC_2000 st075254 36.4 µM -0.301331132697547 0.364365952454982 no 2162 0.381581001523808 2941 17234175 SGTC_1771 st048882 4.1505 µM -0.303080831786664 0.363629156654213 no 2163 0.380914130789104 2923 4580403 SGTC_458 nppb 133 µM -0.303505037515636 0.363450600041135 no 2164 0.380752504517404 3133 4549 A chloride channel blocker. SGTC_2985 9022375 71.43 µM -0.304564570542656 0.363004751195913 no 2165 0.380348903668097 3135 4939335 SGTC_2750 bromebric acid 70.15 µM -0.306787800073292 0.362069825725017 no 2166 0.379502447452459 3096 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2780 5215298 71.43 µM -0.309011130783538 0.361135680005684 no 2167 0.378656529890478 3100 2834131 SGTC_1354 1498-1681 81 µM -0.309599088277408 0.360888784267369 no 2168 0.378432924849796 3040 5754243 SGTC_3084 9116877 49.47 µM -0.310899677147278 0.360342845631099 no 2169 0.377938444960698 3031 27241325 SGTC_2818 7996756 12.99 µM -0.311739876393248 0.359990312617682 no 2170 0.377619110027335 2889 2241621 SGTC_2869 9037858 32.47 µM -0.312005593492591 0.359878847102101 no 2171 0.377518136197849 2921 27187042 SGTC_614 0462-0418 107 µM -0.313439471692666 0.35927755620062 no 2172 0.376973399922733 2997 5188303 SGTC_1697 st025554 27.742 µM -0.314695375146073 0.358751184384382 no 2173 0.376496478039773 2935 1269519 SGTC_1652 st011932 78 µM -0.31595117224586 0.358225125238752 no 2174 0.376019784975152 3069 1551076 SGTC_2761 levamisole 97.89 µM -0.316388574998431 0.358041958342366 no 2175 0.375853793876162 3115 26879 An alkaline phosphatase inhibitor. SGTC_1854 st056233 32.9 µM -0.316830847816434 0.357856785275442 no 2176 0.37568597797842 3060 5393174 SGTC_1670 st016595 4.04 µM -0.317789995262006 0.357455319430056 no 2177 0.375322120119874 3024 597879 SGTC_3022 9087993 49.47 µM -0.319146829164891 0.356887665241529 no 2178 0.374807587175428 3048 17173644 SGTC_2951 9072950 58.06 µM -0.319261416117222 0.356839740357217 no 2179 0.374764144173685 2980 16488155 SGTC_1346 1488-2224 62.4 µM -0.319277103493727 0.356833179439571 no 2180 0.374758196790146 3075 3722427 SGTC_3254 9136651 49.47 µM -0.319827433993124 0.356603042014629 no 2181 0.374549574866717 3005 16454030 SGTC_305 1682-2595 20.8 µM -0.320116815329788 0.356482049347027 no 2182 0.374439889528407 3028 226033 SGTC_1202 1988-0068 29.6 µM -0.320227005086687 0.356435981918326 no 2183 0.374398126545007 2961 2850480 SGTC_2315 7733312 200 µM -0.320784900466322 0.356202772749866 no 2184 0.374186701428783 2970 726316 SGTC_1786 berberine 21.6 µM -0.322591035587251 0.355448148705027 no 2185 0.373502491817774 2958 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1454 4239-0054 42.6 µM -0.322659918071806 0.355419380003173 no 2186 0.37347640526929 3149 1340767 SGTC_3002 9075603 71.4286 µM -0.32341481519098 0.355104151981625 no 2187 0.373190555511785 2979 20105405 SGTC_1484 3473-2379 286 µM -0.323884184647582 0.354908203846249 no 2188 0.373012858988222 3012 671917 SGTC_565 1418-0001 44.5 µM -0.324045781923795 0.354840750547419 no 2189 0.372951686833275 3141 2862145 SGTC_12 0849-0099 9.267 µM -0.324806190770624 0.35452340479484 no 2190 0.372663879412123 3047 6071388 SGTC_1232 0279-0259 161 µM -0.325646934919194 0.354172649775983 no 2191 0.372345748595031 3026 1560000 SGTC_265 mycophenolic acid 32.932 µM -0.326087553551446 0.353988874862193 no 2192 0.372179056819604 3242 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_420 mitomycin C 81.9 mM -0.32975084303583 0.352462296367396 no 2193 0.370794116597942 2985 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3264 9137442 49.47 µM -0.329878863092279 0.352408990194557 no 2194 0.370745747579681 3213 17015726 SGTC_2881 9058953 51.95 µM -0.33028692767495 0.352239095847737 no 2195 0.370591584723018 2947 17122249 SGTC_251 melphalan 456.522 µM -0.33046764058487 0.352163866925427 no 2196 0.370523319768107 3049 460612 A DNA alkylator. SGTC_932 2857-0803 154 µM -0.330727846396627 0.352055556089399 no 2197 0.370425033243653 3214 674898 SGTC_2212 7123476 200 µM -0.331150568093622 0.35187962350118 no 2198 0.370265378262918 3006 1085715 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.332392276389111 0.351363020284901 no 2199 0.369796534943232 2988 229346 A bile salt which induces apoptosis. SGTC_3349 9149703 23.001 µM -0.332615130954456 0.351270332375028 no 2200 0.369712410136225 2956 4910494 SGTC_1733 st037357 54.9 µM -0.333525405093336 0.350891830251777 no 2201 0.369368857841797 2918 1272339 YGL099W LSG1 SGTC_2329 6138490 200 µM -0.334341847009614 0.350552470427169 no 2202 0.369060808065506 3193 720019 SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.334448185973824 0.350508278659658 no 2203 0.369020691746049 2970 16486 A toxic proline analog. SGTC_2711 st079103 59.1 µM -0.334789131823491 0.350366603885692 no 2204 0.36889207972225 3043 54693780 SGTC_2907 7721985 69.9 µM -0.335577186072687 0.350039219821898 no 2205 0.368594865103334 3070 3267881 SGTC_3282 9108498 15.4605 µM -0.337852279654143 0.34909469588891 no 2206 0.367737255202419 3082 16459645 SGTC_2900 5328528 85.29 µM -0.338426622727811 0.348856400043536 no 2207 0.36752085722131 2997 795359 SGTC_3219 9131112 49.47 µM -0.339129943582503 0.348564672304585 no 2208 0.367255920957937 3106 17612988 YMR079W SEC14 SGTC_1879 gemcitabine 100 µM -0.340969684428606 0.347801997102915 no 2209 0.366563201981009 3020 60750 A nucleoside analog which inhibits DNA replication. SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.341469598867703 0.347594860891606 no 2210 0.366375043799955 3011 390807 SGTC_2623 humulene 100 µM -0.341662573365204 0.347514915363066 no 2211 0.36630242049954 3088 6187145 An anti-inflammatory. SGTC_1759 st043059 70 µM -0.342746983815438 0.347065791723952 no 2212 0.365894406648379 2989 669426 SGTC_576 1073-0113 22.7 µM -0.343343963522768 0.346818635895394 no 2213 0.365669855283695 3088 5439563 SGTC_1250 0485-0349 40.2 µM -0.343443841937992 0.34677729155013 no 2214 0.365632290936837 3024 6842794 YDL195W SEC31 SGTC_384 k007-0144 5.16 µM -0.343663402864836 0.346686411432826 no 2215 0.365549718437743 3056 6824886 SGTC_1675 st018485 24.5 µM -0.345927460480473 0.34574979362637 no 2216 0.364698615381546 3044 3323024 SGTC_2113 5491891 107.031 µM -0.347190812640264 0.345227567210524 no 2217 0.364223986260042 3027 789979 SGTC_462 ag-879 158 µM -0.347929810455682 0.34492222736063 no 2218 0.363946448408311 3120 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_873 0591-4978 488 µM -0.348390648034955 0.344731869130119 no 2219 0.363773412463792 3222 3305145 SGTC_2264 7948757 110.76 µM -0.3492889627374 0.344360915191796 no 2220 0.363436191873296 2959 2971411 SGTC_815 1582-0027 36.9 µM -0.349325581245849 0.344345796959866 no 2221 0.363422447802867 3117 3128206 SGTC_1883 5-benzylidenerhodanine 20 µM -0.349503023104962 0.344272542250898 no 2222 0.363355850818994 3131 1273210 SGTC_39 0986-0283 58.349 µM -0.350038103465389 0.344051676226498 no 2223 0.363155050962153 3206 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_1451 4152-0210 104 µM -0.351689715357897 0.343370273372841 no 2224 0.36253548720044 3173 659563 SGTC_1329 1447-1697 50.6 µM -0.352766917962716 0.342926127619678 no 2225 0.362131593465923 3119 2840515 SGTC_3218 9131285 49.47 µM -0.353161427094744 0.342763520216236 no 2226 0.361983711874447 3203 17156417 SGTC_2676 harmalol 100 µM -0.353586367164948 0.342588402477868 no 2227 0.361824446305745 3124 5459187 A monoamine oxidase inhibitor SGTC_3294 9122953 26.2835 µM -0.354027600731386 0.342406605988879 no 2228 0.361659099332668 3011 16459826 SGTC_1163 k060-0048 49.9 µM -0.354625716521258 0.342160229378674 no 2229 0.361435003871498 3025 6809982 SGTC_613 3914-0030 117 µM -0.355126999814864 0.341953791870639 no 2230 0.36124722515298 2940 1145395 SGTC_656 4090-1979 187 µM -0.356176101893343 0.341521905647932 no 2231 0.360854343932641 3160 22330961 SGTC_1189 1431-2119 7.28 µM -0.357238490500678 0.341084761092205 no 2232 0.360456636582638 3065 3107275 SGTC_1706 st031321 9.9705 µM -0.359244799682691 0.340259800339645 no 2233 0.359705982551735 3138 6103185 SGTC_973 1325-0077 65.9 µM -0.3608478981946 0.339601181906168 no 2234 0.359106577074718 3084 2835149 SGTC_2622 2-methoxyxanthone 59.94 µM -0.36204145413181 0.33911113807308 no 2235 0.358660526384338 3073 71034 A hepatoprotective. SGTC_2970 9090938 41.86 µM -0.362803641209623 0.338798345647867 no 2236 0.358375785830362 3234 17217104 SGTC_2875 9039966 71.43 µM -0.363550690469735 0.338491873435355 no 2237 0.358096776912047 3101 6463691 SGTC_971 1315-0384 26.7 µM -0.364246595764277 0.338206478907215 no 2238 0.357836937467818 3060 6769120 SGTC_1314 1222-0010 41.1 µM -0.365026458008918 0.337886763615598 no 2239 0.357545828155277 3107 3526027 SGTC_2192 5915882 198.485 µM -0.36725328319287 0.336974490117453 no 2240 0.356715048792772 3073 2876149 SGTC_3354 9151612 71.43 µM -0.367582063973141 0.336839878060009 no 2241 0.356592445387721 3163 27261949 SGTC_2188 6126565 140.678 µM -0.369168022226663 0.336190836136861 no 2242 0.3560012447963 3167 874518 SGTC_3036 9090181 49.47 µM -0.369314069240754 0.336131091964107 no 2243 0.355946819961307 3024 25236586 SGTC_526 4469-0568 170 µM -0.372543789880361 0.334810954413177 no 2244 0.354744007417661 3057 2901964 SGTC_2266 7929956 200 µM -0.372565191246974 0.334802213458419 no 2245 0.35473604193274 3022 2967153 SGTC_1699 st031318 29.054 µM -0.37461392722585 0.333965863745598 no 2246 0.353973806844223 3170 5340658 SGTC_1736 st036774 51 µM -0.37466083113538 0.333946725927596 no 2247 0.353956363015791 3280 1272247 SGTC_2060 5238662 140 µM -0.375749130955776 0.333502797213943 no 2248 0.353551704316038 3145 790130 SGTC_129 0088-0017 176.636 µM -0.376372995085381 0.333248421652866 no 2249 0.3533198096843 3184 182446 SGTC_2723 salbutamol 83.58 µM -0.37642317802307 0.333227963295975 no 2250 0.353301158702481 3162 9884233 β2-adrenoceptor agonist SGTC_569 4130-2812 160 µM -0.377827215392955 0.332655772927763 no 2251 0.352779477389297 3120 743552 SGTC_657 3534-0529 86.7 µM -0.378079647461668 0.33255294002773 no 2252 0.352685713552724 3209 1049549 SGTC_2891 9063876 19.48 µM -0.378206704874417 0.332501185593015 no 2253 0.352638522496466 3155 6472478 SGTC_2172 5754775 163.918 µM -0.380633157021202 0.331513429891742 no 2254 0.351737737174909 3065 2263357 SGTC_978 1416-0512 87.4 µM -0.381294226209155 0.331244525674649 no 2255 0.351492468733468 3160 6814003 SGTC_3310 9130229 44.1445 µM -0.381650074477268 0.331099812689757 no 2256 0.351360468275983 3202 7761258 SGTC_3322 9139058 2.11 µM -0.382131687309811 0.330903995146313 no 2257 0.351181844519366 3243 4908926 YPR165W RHO1 SGTC_3283 9109332 35.8195 µM -0.383923892090774 0.330175714554692 no 2258 0.350517428777474 3093 17027281 SGTC_60 0986-0278 202 µM -0.384165098817121 0.330077746785628 no 2259 0.350428042182287 3055 3110598 SGTC_876 0720-0963 56.8 µM -0.384968584617148 0.329751489582804 no 2260 0.350130345498542 3255 765861 SGTC_25 0118-0223 35.662 µM -0.385694460489547 0.329456857391021 no 2261 0.349861482948531 3228 5333628 SGTC_996 3970-0799 1.8 µM -0.386327093458371 0.32920015870201 no 2262 0.349627218706304 3140 6615648 YGL040C HEM2 SGTC_946 3434-1334 87.4 µM -0.38722709357811 0.328835111213564 no 2263 0.349294046972415 3205 4047976 SGTC_1309 pyrazolanthrone 13.4 µM -0.387234123505836 0.328832260458806 no 2264 0.349291445014725 3204 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1508 1080-0625 72.9 µM -0.387972220206073 0.328533005185051 no 2265 0.349018295809755 3051 767111 SGTC_2267 7931562 200 µM -0.38924835048991 0.328015868053353 no 2266 0.348546219807541 3030 934880 SGTC_1613 st002381 52.1 µM -0.390792164388757 0.327390695711786 no 2267 0.347975433627657 3169 551167 SGTC_1956 st077085 54 µM -0.391511578133666 0.327099531969162 no 2268 0.347709566093597 3118 24208685 SGTC_874 0599-0792 117 µM -0.393175930584412 0.326426332652222 no 2269 0.347094772884038 3256 765305 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.393735930253808 0.326199950217827 no 2270 0.34688800561336 3231 688664 SGTC_2830 7992007 71.43 µM -0.396488313329319 0.325088218724012 no 2271 0.345872413794478 2948 1952075 SGTC_877 0771-0151 33.1 µM -0.397024216748312 0.324871939371303 no 2272 0.345674801372781 3174 6166523 SGTC_3069 9117009 49.47 µM -0.399470239415611 0.323885526369494 no 2273 0.344773374057478 3122 41904981 SGTC_1701 st028638 40.4 µM -0.401705423133013 0.322985218879855 no 2274 0.343950416449181 3226 3490878 SGTC_3213 9129884 49.47 µM -0.402719646522886 0.322577042245354 no 2275 0.34357723959963 3167 17190742 SGTC_80 0159-0065 512.242 µM -0.403156015271113 0.32240149032955 no 2276 0.343416727447953 3214 1548079 SGTC_1666 st014829 29 µM -0.403452258127099 0.322282333869635 no 2277 0.343307774738731 3092 3858230 SGTC_578 3460-0051 92 µM -0.403580769916622 0.322230648816156 no 2278 0.343260514499912 3251 2876744 SGTC_2263 7948595 193.29 µM -0.404599414507252 0.321821090553733 no 2279 0.342885994494998 3082 2971371 SGTC_2405 ticlatone 3.52 µM -0.404612829391504 0.321815698381304 no 2280 0.342881063339875 2926 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1522 st012842 45.6 µM -0.404620892741056 0.321812457300122 no 2281 0.342878099359424 3011 3491067 YOR116C RPO31 SGTC_495 decylubiquinone 155 µM -0.404693521548624 0.321783264601376 no 2282 0.342851402407986 3162 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1571 st070080 73.4 µM -0.405993793168953 0.321260814780364 no 2283 0.342373580479764 3275 4315245 SGTC_2802 7925815 54.55 µM -0.406862731081555 0.320911872052736 no 2284 0.342054404966382 3099 1262923 SGTC_144 4161-2749 112.381 µM -0.407552494004262 0.320634993872445 no 2285 0.341801123755057 3155 797501 YMR168C CEP3 SGTC_2472 5377652 49.4 µM -0.407960998330866 0.320471062915635 no 2286 0.341651154368348 3156 1610903 SGTC_2829 7992743 58.44 µM -0.408854841568114 0.320112489804708 no 2287 0.34132309541289 3247 16462845 SGTC_1967 st070177 51.4 µM -0.410521074866034 0.31944451413318 no 2288 0.340711873489478 3274 5729214 SGTC_2268 7933382 153.85 µM -0.410606192623014 0.319410407006649 no 2289 0.340680661075742 3189 935025 YOR257W CDC31 SGTC_1036 k216-0215 33.5 µM -0.411036079036956 0.319238172641267 no 2290 0.340523039750969 3097 622330 SGTC_1070 indatraline 8.81 µM -0.411144802169207 0.319194618802253 no 2291 0.340483179948032 3152 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1709 st033179 39.1045 µM -0.412976414996307 0.318461261133117 no 2292 0.339811946785234 3125 573381 SGTC_3186 9110464 49.47 µM -0.413244601042527 0.318353941967612 no 2293 0.339713706903518 3250 17018021 SGTC_812 4251-0442 148 µM -0.413620599246529 0.318203505617107 no 2294 0.339575992421463 3251 5723007 SGTC_3074 9116018 49.47 µM -0.416637855248255 0.316997393119567 no 2295 0.338471657994636 3106 17027303 SGTC_2939 9044578 71.43 µM -0.416642794246758 0.316995420401759 no 2296 0.338469851425638 3088 2653634 SGTC_3195 9113082 49.47 µM -0.41757106058529 0.316624747865903 no 2297 0.338130379572407 3240 17018038 SGTC_2176 5809774 33.9695 µM -0.418174878281659 0.31638373197446 no 2298 0.337909630890136 3234 2870539 SGTC_125 0133-0007 11.75 µM -0.4188980800906 0.316095166126153 no 2299 0.337645310129777 3285 26541 SGTC_2296 7971656 126.45 µM -0.419882191820792 0.315702674123783 no 2300 0.337285758843135 3204 666570 SGTC_2942 9052777 62.25 µM -0.420694788461982 0.315378743829865 no 2301 0.336988983602491 3169 6469503 SGTC_1534 6-azauridine 81.6 µM -0.421123313008155 0.315207975619809 no 2302 0.336832519396774 3163 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_818 4072-2707 53.5 µM -0.423043971924074 0.314443073179955 no 2303 0.336131589672468 3084 882871 SGTC_182 3448-4371 550.524 µM -0.423098183744742 0.314421494856264 no 2304 0.336111813735847 3245 3491403 SGTC_358 0075-0058 9.45 µM -0.423137160150886 0.314405981186772 no 2305 0.336097595808224 3377 1069125 SGTC_1031 k035-0009 16 µM -0.42382856090135 0.314130839384105 no 2306 0.335845423605878 3293 5180959 SGTC_2371 9071574 200 µM -0.423936630646686 0.314087842533502 no 2307 0.335806014376079 3246 45596039 SGTC_1948 st076329 66.6 µM -0.424456722388936 0.313880953067746 no 2308 0.335616380495141 3156 24208413 SGTC_2446 5162541 200 µM -0.425943362691186 0.313289898977226 no 2309 0.335074558310201 3107 1549321 SGTC_2174 5790901 200 µM -0.427161414582348 0.312805986583313 no 2310 0.334630881675424 3222 786020 SGTC_2196 6573537 42.6665 µM -0.427452433809653 0.312690417020011 no 2311 0.3345249117641 3276 2903087 SGTC_2825 7998094 58.44 µM -0.429570683193468 0.311849773101457 no 2312 0.333753983365932 3180 2987815 SGTC_2871 9038510 12.99 µM -0.430988527742784 0.311287637121446 no 2313 0.333238356073264 3345 4945164 SGTC_2240 6690706 185.951 µM -0.43172185602437 0.310997065292421 no 2314 0.332971790235347 3046 805876 SGTC_3313 9133968 57.047 µM -0.432383790712389 0.310734883384469 no 2315 0.332731248520902 3236 1494643 SGTC_1857 st056007 79.3 µM -0.433481209816905 0.310300424682198 no 2316 0.332332606993901 3262 619834 SGTC_3068 9116768 49.47 µM -0.434349027534773 0.309957050479809 no 2317 0.332017503238642 3262 41904888 SGTC_3221 9128209 49.47 µM -0.434618517262932 0.309850453702485 no 2318 0.331919675940002 3188 16460723 SGTC_1588 farnesol 29.9 µM -0.435530821382738 0.309489710114693 no 2319 0.331588586068404 3161 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_1221 2958-7315 257 µM -0.435537219420431 0.309487180848126 no 2320 0.331586264581568 3249 4562705 SGTC_3037 9091026 49.47 µM -0.435732343756536 0.30941004880393 no 2321 0.33151546807831 3264 25236398 YIL048W NEO1 SGTC_686 1319-0111 510 µM -0.438145049208609 0.30845700845488 no 2322 0.330640569867245 3332 4562600 SGTC_161 4065-0411 162.148 µM -0.438204827613584 0.308433411789049 no 2323 0.330618904666884 3257 1906281 YLR208W SEC13 SGTC_2743 auranofin 4.32 µM -0.438587821477674 0.30828224924775 no 2324 0.330480111507682 3190 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_32 0928-0142 34.1 µM -0.43876125454363 0.308213808233422 no 2325 0.330417268760559 3249 2244242 SGTC_167 3672-0051 66.205 µM -0.438854954809958 0.308176834544762 no 2326 0.330383318849925 3137 3237971 SGTC_2179 6298986 200 µM -0.440953332651505 0.307349334851019 no 2327 0.329623391102332 3279 738374 SGTC_1806 st050005 60.3 µM -0.441960566809989 0.30695247768543 no 2328 0.329258870631971 3186 5194765 SGTC_2135 5326629 150.42 µM -0.443356263427797 0.306402937398393 no 2329 0.328754032875917 3187 5020077 SGTC_1308 1187-1617 41.4 µM -0.443636728039435 0.306292559990358 no 2330 0.328652623611851 3170 2882570 SGTC_824 1304-0008 100 µM -0.443865244426307 0.306202639904635 no 2331 0.328570006905273 3190 768245 SGTC_611 3453-1652 23.7 µM -0.444944647945563 0.305778057741573 no 2332 0.328179877918288 3292 1560575 SGTC_118 0083-0097 135.343 µM -0.446040448821747 0.305347292584191 no 2333 0.327784014048083 3282 5207356 SGTC_633 0437-0093 97.7 µM -0.446881502639707 0.30501685254853 no 2334 0.327480310093742 3205 2831118 SGTC_2755 lomerizine 42.69 µM -0.44913107970415 0.304133802021713 no 2335 0.326668550697697 3203 3949 A calcium channel blocker. SGTC_137 0438-0332 85.389 µM -0.449384107848333 0.304034549488887 no 2336 0.326577296773516 3302 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1338 1486-1223 76 µM -0.449740551920116 0.303894755643262 no 2337 0.326448763775599 3228 3444526 SGTC_852 0418-0143 439 µM -0.450114612265015 0.303748083704252 no 2338 0.326313900541797 3298 5369229 SGTC_1140 3229-1848 2.98 µM -0.450341550595075 0.303659114837808 no 2339 0.326232091554293 3291 2849525 SGTC_2624 nerol 100 µM -0.451646462262787 0.30314776339103 no 2340 0.325761846362543 3212 637566 A natural product oil. SGTC_2098 5376439 882.5 nM -0.452152326983166 0.302949635483008 no 2341 0.325579624638532 3280 2844116 SGTC_2491 paeonol 100 µM -0.453268056934893 0.302512851654945 no 2342 0.325177865680649 3222 11092 Increases levels of cortical cytochrome oxidase. SGTC_2583 asiatic acid 100 µM -0.453425216343963 0.302451349880023 no 2343 0.325121291058421 3367 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_635 k038-0028 24.7 µM -0.454186712317678 0.30215343026534 no 2344 0.324847223015883 3207 4035102 SGTC_1781 st038725 66.3 µM -0.455649400694375 0.301581553428305 no 2345 0.324321056594887 3174 4270275 YIL048W NEO1 SGTC_990 3985-0011 41.3 µM -0.455955022810994 0.301462123874585 no 2346 0.324211160749029 3232 5399565 YGL099W LSG1 SGTC_2438 5259590 200 µM -0.456846666835755 0.301113813171576 no 2347 0.323890630211559 3274 1201127 SGTC_332 4112-0506 40.9 µM -0.458067676663793 0.300637133865622 no 2348 0.32345191020605 3212 2790355 SGTC_3340 9146634 11.102 µM -0.458697587716292 0.300391351374779 no 2349 0.323225673288506 3296 4907387 SGTC_2888 9058547 12.99 µM -0.459860713422846 0.299937754739907 no 2350 0.322808100451862 3186 16476514 SGTC_1405 3909-7894 12 µM -0.460388793948238 0.299731915870205 no 2351 0.322618588357411 3299 7104060 SGTC_1056 3448-1962 115 µM -0.46091304141661 0.299527634383772 no 2352 0.322430497399498 3287 715507 SGTC_628 1636-0253 16 µM -0.462363642091588 0.298962713583815 no 2353 0.321910283835762 3255 4456143 SGTC_1087 pterostilbene 9.05 µM -0.462620719096809 0.298862648215152 no 2354 0.321818127390272 3329 5281727 Similar to reservatol, lowers cholesterol. SGTC_1626 st003712 1.76 µM -0.465824816941374 0.297616755182967 no 2355 0.320670449920166 3337 24207035 SGTC_3013 9080133 71.4286 µM -0.465847698677583 0.297607866296048 no 2356 0.320662260043783 3412 17050193 SGTC_1088 bifonazole 369 nM -0.467156909474593 0.29709947804037 no 2357 0.32019381021791 3282 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_3108 9121785 49.47 µM -0.468084938849076 0.296739349535433 no 2358 0.319861924674662 3300 17140271 SGTC_1217 1183-1422 255 µM -0.469130422248239 0.29633388172592 no 2359 0.319488207425768 3343 2849664 SGTC_3341 9147222 25.867 µM -0.469620834640784 0.29614377360261 no 2360 0.31931296831768 3343 1939759 SGTC_2275 7947463 200 µM -0.469955637258508 0.296014019682563 no 2361 0.319193356442523 3319 1225414 SGTC_3271 9137798 49.47 µM -0.470297107566462 0.295881708563905 no 2362 0.319071381847045 3297 6498326 SGTC_2035 5154463 94.595 µM -0.470913165860596 0.295643070265024 no 2363 0.318851372848164 3352 2769623 SGTC_1984 st072354 53.1 µM -0.471334480765766 0.295479919340849 no 2364 0.31870094806495 3171 5762938 SGTC_1893 st059353 36.1 µM -0.47314416157906 0.294779605883302 no 2365 0.318055165968423 3276 3112488 SGTC_799 1310-0557 151 µM -0.473602230993804 0.294602462820047 no 2366 0.317891792123514 3364 5354492 SGTC_186 3455-3465 67.277 µM -0.474162326669371 0.294385931266395 no 2367 0.317692078018703 3222 755278 SGTC_345 1362-0200 395 µM -0.47423814744367 0.294356624796923 no 2368 0.31766504657266 3246 1419823 SGTC_2522 biochanin a 4.94 µM -0.475794010580391 0.293755545668395 no 2369 0.317110568648693 3352 5280373 A possible chelator. SGTC_281 1672-3440 14.9 µM -0.476353017977079 0.293539722209699 no 2370 0.316911449941329 3321 6833000 SGTC_801 0866-0028 10.1 µM -0.476454855872532 0.293500412200383 no 2371 0.316875180940683 3208 6849771 SGTC_2076 5212012 200 µM -0.477753813976865 0.292999220976525 no 2372 0.316412718704003 3266 604802 SGTC_451 chloral hydrate 100 µM -0.477843488571276 0.292964635503749 no 2373 0.316380802839964 3325 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_1716 st033144 30.6155 µM -0.478108896486406 0.292862284746212 no 2374 0.316286350176897 3403 674617 SGTC_3044 9093193 49.47 µM -0.478712552189374 0.292629555407683 no 2375 0.31607156742699 3311 25236277 SGTC_625 k213-0058 121 µM -0.479011425208576 0.292514361733097 no 2376 0.315965250356527 3316 3655420 SGTC_706 4262-0057 46.9 µM -0.479738355944809 0.292234271140249 no 2377 0.315706725329254 3246 883298 SGTC_141 0443-0274 32.331 µM -0.480219729966105 0.29204886365438 no 2378 0.315535579486002 3420 1627241 SGTC_2993 9054257 71.4286 µM -0.48108750386506 0.291714767617459 no 2379 0.315227154490124 3253 6470217 YGL055W OLE1 SGTC_2701 st077767 14.721 µM -0.483392083910234 0.290828361894839 no 2380 0.314408683925641 3293 5721188 SGTC_3072 9116419 49.47 µM -0.48356783049284 0.290760816564589 no 2381 0.314346304960766 3283 17170162 SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.486101388808866 0.289787900888002 no 2382 0.31344764114996 3320 75037 A free radical scavenger. SGTC_110 0850-0284 111.64 µM -0.486889379396295 0.289485615091826 no 2383 0.31316836286759 3181 3906265 SGTC_2415 st077333 57.7 µM -0.487159159259711 0.289382157261038 no 2384 0.313072772558001 3449 2766255 SGTC_2385 9074692 200 µM -0.488455228046391 0.288885370434108 no 2385 0.312613715534747 3280 17046906 SGTC_507 nimesulide 162 µM -0.490108768489927 0.288252147028795 no 2386 0.312028466805715 3421 4495 A COX2 inhibitor. SGTC_2424 5537928 59.2 µM -0.490262222143659 0.288193415154582 no 2387 0.311974177940386 3266 5382802 SGTC_2950 9072895 21.46 µM -0.490472305104778 0.288113018495583 no 2388 0.311899861370181 3348 17332245 SGTC_1742 st038235 28.8875 µM -0.490893663571681 0.287951800710212 no 2389 0.3117508294515 3327 564103 YBR002C RER2 SGTC_2543 pimpinellin 60.67 µM -0.490997039523043 0.28791225409788 no 2390 0.311714270716195 3216 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_3238 9133470 49.47 µM -0.491004305473023 0.287909474595191 no 2391 0.311711701194717 3381 3534688 SGTC_1660 st012960 28.1 µM -0.49181698479648 0.287598673784748 no 2392 0.311424364169559 3328 24207266 SGTC_3305 9127027 53.8275 µM -0.493382584349116 0.287000373881704 no 2393 0.310871142790116 3250 41905295 SGTC_3157 9099274 49.47 µM -0.493618295917366 0.286910346884138 no 2394 0.310787888553989 3393 17217662 SGTC_2969 9091408 28.7 µM -0.494216303550386 0.286682005624511 no 2395 0.31057671341661 3212 4286311 SGTC_2791 5663188 71.43 µM -0.494773957639067 0.286469150504124 no 2396 0.310379844600803 3391 54690634 SGTC_1951 sophoraflavanone G 9.2 µM -0.496621652437735 0.28576442658315 no 2397 0.309727940615768 3255 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_1398 3558-0053 112 µM -0.497042641351866 0.285603973839104 no 2398 0.309579490813201 3204 4532369 SGTC_1564 D-Arginine 115 µM -0.498576029368995 0.285019911920543 no 2399 0.309039047754387 3295 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_120 rhodamine 6G 52.259 µM -0.500555637487519 0.284266729705089 no 2400 0.308341945213476 3248 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1632 st005650 90 µM -0.50157458355448 0.283879422181339 no 2401 0.307983400844108 3325 2759605 SGTC_605 1315-0399 119 µM -0.503280418967224 0.283231589840774 no 2402 0.30738356565839 3407 24020461 SGTC_3205 9113483 49.47 µM -0.504527054197999 0.282758598843152 no 2403 0.306945527811057 3407 17018033 SGTC_3 0833-0587 95.581 µM -0.505314505483664 0.282460024404752 no 2404 0.306668978136429 3337 5382644 SGTC_1744 st037937 38.9 µM -0.506212009320026 0.282119906818474 no 2405 0.306353912621721 3426 1016152 SGTC_1449 4112-4002 201 µM -0.507426719886516 0.281659894994356 no 2406 0.305927720771529 3326 2059539 SGTC_2824 7998404 51.95 µM -0.508165623184587 0.281380248774659 no 2407 0.305668598502558 3274 837851 SGTC_724 3910-0327 137 µM -0.508542118674374 0.281237811395544 no 2408 0.305536604603638 3376 2885483 SGTC_2974 9094440 9.66 µM -0.50943023648888 0.280901952867514 no 2409 0.30522534341762 3422 25236134 SGTC_2109 5483026 200 µM -0.509629149457086 0.280826756753786 no 2410 0.305155649113469 3316 759335 SGTC_398 bronopol 33.3 µM -0.510767348458126 0.280396664689812 no 2411 0.304756987580437 3261 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_2990 9074105 71.4286 µM -0.511100133776526 0.280270975147423 no 2412 0.304640471136576 3364 6502001 SGTC_2218 6965428 192.983 µM -0.511835784143207 0.279993224561727 no 2413 0.304382971920892 3381 675684 SGTC_2707 st078556 66.6 µM -0.512364513446335 0.279793681109082 no 2414 0.304197961016948 3331 17250899 SGTC_3244 9134489 49.47 µM -0.512818875838315 0.279622259006454 no 2415 0.304039012328241 3365 16584271 SGTC_512 prima-1 270 µM -0.513261193063799 0.279455430296318 no 2416 0.303884312947953 3424 322968 A re-activator of the apoptotic function of mutant p53. SGTC_1093 fluphenazine 7.97 µM -0.513961512966026 0.27919138966072 no 2417 0.303639449579645 3341 6602611 An atypical antipsychotic. SGTC_1180 1193-0155 285 µM -0.516353947908147 0.27829028908517 no 2418 0.302803611860392 3393 2921347 SGTC_11 0438-0307 1.3 µM -0.516549451197997 0.278216716301753 no 2419 0.302735355030973 3411 4011476 SGTC_1053 3366-3204 134 µM -0.517043281815045 0.278030917721624 no 2420 0.302562972711958 3319 3632071 YPR165W RHO1 SGTC_2560 caryophyllene 100 µM -0.517460019133075 0.277874171800106 no 2421 0.302417535724479 3319 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_2569 tetrandrine 100 µM -0.517528651609652 0.277848361449147 no 2422 0.302393586711404 3292 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2731 amoxapine 43.43 µM -0.51820448434158 0.277594266163236 no 2423 0.302157803174126 3392 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_1356 1502-0781 85.8 µM -0.519166316780054 0.277232838413965 no 2424 0.301822382857674 3297 567702 SGTC_253 dyclonine 31.25 µM -0.520298149372729 0.276807824737786 no 2425 0.301427892778436 3401 3180 An oral anasthetic. SGTC_1518 st038567 90.8 µM -0.52037196183726 0.276780118559527 no 2426 0.301402174169962 3392 77966 SGTC_1331 1472-0049 76.2 µM -0.521412181754553 0.276389807113257 no 2427 0.301039833593884 3291 24051409 SGTC_658 3253-0951 102 µM -0.522010546170431 0.276165411118926 no 2428 0.300831493868645 3361 1184878 SGTC_684 1140-0066 328 µM -0.522403493055816 0.276018098563582 no 2429 0.300694712222923 3383 6813534 SGTC_1122 capsaicin 818.572 nM -0.522790359447207 0.275873103241912 no 2430 0.300560074575029 3416 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_823 0417-1665 178 µM -0.524814270691707 0.275115163355852 no 2431 0.299856155015057 3366 3429856 SGTC_2760 etidronate 98.04 µM -0.525635220964765 0.274808016131424 no 2432 0.299570840119071 3309 3305 A chelator and antioxidant. SGTC_2795 7780010 54.55 µM -0.526012733490014 0.274666831785862 no 2433 0.299439679878967 3409 953673 SGTC_1727 st034309 9.9045 µM -0.527217060724454 0.274216669660532 no 2434 0.299021431202028 3478 870305 SGTC_1990 st072050 59.8 µM -0.527747796452585 0.274018403165052 no 2435 0.298837197179267 3308 17233948 SGTC_2805 7950783 58.44 µM -0.528254899013628 0.273829031495968 no 2436 0.298661215125849 3389 1178958 YDL195W SEC31 SGTC_1728 st035614 33.7865 µM -0.529680571629851 0.273296977279298 no 2437 0.298166710272328 3348 15945546 SGTC_343 4130-2827 29.8 µM -0.530139296718436 0.273125892213861 no 2438 0.298007677501566 3353 1118244 SGTC_77 0828-0286 12.516 µM -0.530809858108293 0.272875896701513 no 2439 0.297775274004717 3408 745345 SGTC_3123 9126162 49.47 µM -0.531066612260849 0.272780204892813 no 2440 0.297686309916756 3361 25239884 SGTC_48 0382-0018 55 µM -0.531856761167974 0.27248582231396 no 2441 0.29741260321442 3554 762596 SGTC_1495 4469-0029 237 µM -0.532027552053119 0.272422212186543 no 2442 0.297353456552706 3411 793680 SGTC_868 0527-0199 213 µM -0.532118531465701 0.272388330414882 no 2443 0.297321951628701 3310 2849450 SGTC_1568 digitonin 820 nM -0.532288125400097 0.272325177286097 no 2444 0.297263227644486 3470 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2047 4141938 200 µM -0.533719801785614 0.271792341913707 no 2445 0.29676770347663 3336 3807862 SGTC_2150 5556613 200 µM -0.534162644496613 0.271627631674605 no 2446 0.296614505737603 3343 743190 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.53694670742529 0.270593271313584 no 2447 0.295652213240123 3384 6708739 YPR165W RHO1 SGTC_759 3486-0358 89.3 µM -0.537104491930392 0.270534708744796 no 2448 0.295597719086169 3476 875103 SGTC_473 2-arachidonoylglycerol 10 µM -0.537806754378245 0.270274137086178 no 2449 0.295355234203178 3289 5282280 An endocannabinoid. SGTC_1937 st074714 47.2 µM -0.538643318329887 0.269963897258663 no 2450 0.295066495736106 3300 17250970 SGTC_1273 0849-0096 14.1 µM -0.541665126391206 0.268844746117784 no 2451 0.294024608984853 3393 5286025 SGTC_1167 k781-0610 148 µM -0.54200821335087 0.268717828517909 no 2452 0.293906423899369 3376 4525169 SGTC_412 gemfibrozil 100 µM -0.544226758031598 0.267897853238905 no 2453 0.293142720318095 3436 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1485 3909-9022 254 µM -0.54430696098569 0.267868233804035 no 2454 0.293115128794549 3436 714516 SGTC_2354 9060492 162 µM -0.54464971319144 0.267741671936548 no 2455 0.292997228313527 3440 6471895 SGTC_1587 estradiol valerate 56.1 µM -0.545172204141684 0.267548799208279 no 2456 0.292817543344417 3456 13791 A steroid. SGTC_963 1269-2853 151 µM -0.54649731355609 0.26705996157821 no 2457 0.292362066930203 3358 3668223 SGTC_2099 5377090 177.372 µM -0.549870906699445 0.265817469950519 no 2458 0.291203960114086 3417 2243829 SGTC_528 3492-0019 172 µM -0.550209080852711 0.265693082444229 no 2459 0.291087987917795 3454 2869262 SGTC_416 estradiol valerate 100 µM -0.551515083706995 0.265212984586601 no 2460 0.290640314765313 3447 13791 A steroid. SGTC_229 benomyl 22.8748 µM -0.551966343566881 0.265047200045772 no 2461 0.290485706296593 3437 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_295 k015-0027 31 µM -0.552216671222196 0.264955256995202 no 2462 0.290399956850221 3423 3887424 SGTC_1411 3909-8223 150 µM -0.55380540923751 0.264372106194911 no 2463 0.289856012976902 3461 X1411 SGTC_2733 amorolfine 100 µM -0.553932790004629 0.264325379030462 no 2464 0.289812421713753 3424 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_431 k089-0097 107 µM -0.554156784367083 0.264243221241141 no 2465 0.289735775551458 3393 5499420 SGTC_1605 st000082 49.1 µM -0.554413985586739 0.26414889971374 no 2466 0.289647778434219 3450 1114022 SGTC_901 1112-0062 60.1 µM -0.554912517270043 0.263966125675621 no 2467 0.289477249848125 3412 1908457 SGTC_1259 0671-0132 43 µM -0.557040332455771 0.263186741362601 no 2468 0.288749936469555 3338 X1259 SGTC_1353 1498-1206 8.11 µM -0.557846837132783 0.26289163926805 no 2469 0.288474488302455 3500 6756808 SGTC_3286 9117135 37.221 µM -0.558640361981892 0.262601451736215 no 2470 0.28820359410054 3355 3438150 SGTC_838 0109-0203 71.4 µM -0.559225676231934 0.262387510734381 no 2471 0.288003855946368 3441 759422 SGTC_1554 st069299 38.7 µM -0.559641906879999 0.262235426606198 no 2472 0.287861857242859 3449 24207999 SGTC_1474 0330-0125 5.35 µM -0.560248436858515 0.262013890975082 no 2473 0.287654996399188 3475 X1474 SGTC_2913 7966556 36.57 µM -0.560923810267368 0.261767323160509 no 2474 0.287424738774592 3444 2976516 SGTC_1521 st012942 49.4 µM -0.561929752198246 0.261400290984827 no 2475 0.28708194087867 3474 24207259 SGTC_2088 5278280 127.392 µM -0.56318304993248 0.260943377589156 no 2476 0.286655121845433 3490 791502 SGTC_2956 9076196 2.52 µM -0.563847738113996 0.260701219721215 no 2477 0.286428879967049 3518 16423868 SGTC_2555 cholic acid 100 µM -0.564262864027003 0.260550040569152 no 2478 0.286287625336856 3500 6708657 Influences liver metabolism. SGTC_3356 9151811 4.48 µM -0.565787392423826 0.259995230477704 no 2479 0.285769159002659 3378 1859254 YPR165W RHO1 SGTC_285 1486-1325 46 µM -0.566081797535912 0.259888160080117 no 2480 0.285669088272999 3486 22310230 SGTC_2893 9048488 25.97 µM -0.566527180995277 0.259726224533576 no 2481 0.285517730454664 3409 6467338 SGTC_3122 9126309 49.47 µM -0.566541800237442 0.25972091005295 no 2482 0.285512762941131 3480 17591206 SGTC_1934 st074720 32.6 µM -0.567408359098404 0.259405993310434 no 2483 0.285218385984497 3449 17250992 SGTC_1206 3978-0017 132 µM -0.568990633647977 0.258831487172188 no 2484 0.284681248147396 3542 3873677 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.569501400052349 0.258646174286854 no 2485 0.284507960433885 3499 7104 SGTC_1553 gossypol 38.6 µM -0.570259331533366 0.258371313251291 no 2486 0.284250909918861 3420 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_38 0929-0051 58.268 µM -0.570397078942837 0.258321375922222 no 2487 0.284204205163971 3437 1379719 SGTC_3275 9138069 49.47 µM -0.570580655101621 0.25825483215172 no 2488 0.284141967377938 3471 17617007 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.570589373254407 0.258251672165203 no 2489 0.284139011826585 3384 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_542 3381-0244 89.3 µM -0.570661646013441 0.258225476912413 no 2490 0.284114511118665 3512 1112843 SGTC_1758 st042942 75.2445 µM -0.570773680741994 0.258184872661121 no 2491 0.284076532966916 3464 669317 SGTC_1089 terbinafine 2.25 µM -0.571088696252546 0.258070720722928 no 2492 0.283969760282441 3477 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_126 0417-1624 672.48 µM -0.573040322086151 0.257364095324823 no 2493 0.283308696371328 3564 41912 YDL195W SEC31 SGTC_116 0155-0182 31.788 µM -0.575702300474851 0.256401895981429 no 2494 0.282408210073956 3428 771486 SGTC_3127 9126946 49.47 µM -0.577032645014382 0.255921732791659 no 2495 0.281958701501115 3404 27243249 SGTC_351 caspofungin 25 nM -0.577137726007141 0.255883825761077 no 2496 0.281923210498275 3473 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_2859 9028643 45.46 µM -0.577335572734034 0.255812462272595 no 2497 0.281856393800544 3446 17151580 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.578134651623032 0.255524339562012 no 2498 0.281586606952722 3513 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1325 1431-0015 227 µM -0.581435044722853 0.25433612014916 no 2499 0.280473642077714 3405 1103340 SGTC_3125 9127534 49.47 µM -0.587252995117181 0.252248594964973 no 2500 0.278516902504618 3424 1639235 SGTC_3184 9108758 49.47 µM -0.588655032344105 0.251746887616951 no 2501 0.27804635445799 3493 902885 SGTC_1722 st034304 3.6505 µM -0.588752186205374 0.251712141448426 no 2502 0.278013762309444 3460 4036148 YLR033W RSC58 SGTC_1090 efavirenz 20.7 µM -0.588768514901701 0.251706301891727 no 2503 0.2780082847143 3505 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_3325 9138760 55.175 µM -0.588809131993799 0.251691776497887 no 2504 0.277994659605946 3402 43844959 SGTC_860 0443-0016 25.1 µM -0.589303824734885 0.251514901119356 no 2505 0.277828739806201 3494 5337942 SGTC_1897 st060201 15 µM -0.589979568365456 0.251273397904533 no 2506 0.277602173748332 3472 611878 SGTC_153 4077-0274 519.67 µM -0.592161689068213 0.250494370390183 no 2507 0.276871160505239 3619 3121976 SGTC_1272 0839-0021 27 µM -0.593030652319007 0.250184503041233 no 2508 0.276580319375865 3493 5027250 SGTC_2325 6158266 200 µM -0.594067801086049 0.249814927984501 no 2509 0.276233382880577 3473 3623240 SGTC_630 4356-0227 183 µM -0.594986995789965 0.249487626821559 no 2510 0.275926081797021 3516 779312 SGTC_1832 st054113 55 µM -0.595456758784194 0.249320444549084 no 2511 0.275769097588255 3512 1251267 SGTC_257 daunorubicin 18.5 µM -0.596169299299229 0.249066974780167 no 2512 0.275531066415253 3510 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2703 st077852 53.4 µM -0.596874854946287 0.248816124863834 no 2513 0.275295468217198 3516 6281836 SGTC_1889 st059080 5.18 µM -0.596974032239811 0.248780874623468 no 2514 0.275262359018071 3540 176925 Isolated from Daphnopsis sellowiana. SGTC_1476 4112-3294 3.34 µM -0.598936660013771 0.248083851944267 no 2515 0.274607561784271 3546 704369 SGTC_993 3909-8757 62.7 µM -0.599432857296735 0.247907793769785 no 2516 0.274442135800258 3450 4288324 YLR208W SEC13 SGTC_2933 9026794 32.47 µM -0.600070671408715 0.247681585824199 no 2517 0.274229568797263 3454 17586027 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.600149251072378 0.247653724292035 no 2518 0.274203385847729 3484 2333 A French combination drug. SGTC_2776 terbinafine 19.92 µM -0.600416884484598 0.247558843637718 no 2519 0.274114218959414 3513 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2963 9082507 9 µM -0.60136945775635 0.247221297632018 no 2520 0.273796968304527 3521 16459611 SGTC_2183 6420625 130.508 µM -0.601579901912495 0.247146759581866 no 2521 0.273726905230293 3561 2897619 SGTC_1611 st001856 99.4 µM -0.601596083957689 0.247141028496815 no 2522 0.273721518116773 3465 647478 SGTC_2570 licareol 100 µM -0.601618454490895 0.247133105794047 no 2523 0.273714070899631 3464 443158 SGTC_995 3931-2021 34.6 µM -0.60173476331945 0.247091916283993 no 2524 0.273675352959414 3496 730143 SGTC_1322 1348-1070 12 µM -0.601764653688492 0.247081331527177 no 2525 0.273665403219278 3517 6758089 SGTC_2629 bisabolol 100 µM -0.602989706718075 0.246647725357833 no 2526 0.27325776840733 3546 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_2002 4023503 131 µM -0.603632797935186 0.246420267158711 no 2527 0.273043901092583 3601 4736863 YCR052W RSC6 SGTC_1013 4112-3890 241 µM -0.606948832982103 0.24524918828578 no 2528 0.271942434566836 3432 705171 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.60763764570943 0.245006305550055 no 2529 0.271713913512976 3598 5393153 SGTC_2235 salicylic acid 500 µM -0.608387378155345 0.244742089019086 no 2530 0.271465290374765 3530 338 A COX inhibitor and kinase inhibitor. SGTC_1904 st060225 78 µM -0.609369494636794 0.244396209220554 no 2531 0.271139776565926 3530 66595 SGTC_1458 k015-0034 6.33 µM -0.609675255745265 0.244288580684767 no 2532 0.271038474499796 3490 3598957 SGTC_1130 3454-2858 15.9 µM -0.612241196465814 0.243386371999249 no 2533 0.270189094423957 3452 715628 YIL048W NEO1 SGTC_333 3486-0131 40.1 µM -0.612722958329559 0.243217181016853 no 2534 0.270029769725825 3608 6744690 SGTC_1386 3228-0095 33.8 µM -0.612921343315596 0.243147528254518 no 2535 0.269964174987238 3529 870181 SGTC_1435 4092-0789 56.7 µM -0.613586079286347 0.242914218783024 no 2536 0.269744442393631 3553 2248285 SGTC_356 1634-0012 32.5 µM -0.615033370827865 0.242406666653764 no 2537 0.269266341215601 3541 735457 SGTC_2595 hexamethylquercetagetin 100 µM -0.615706019781854 0.242170970429957 no 2538 0.269044281773332 3469 386331 SGTC_1682 st012968 530 nM -0.616263439980223 0.241975744544176 no 2539 0.26886033209807 3433 24207270 SGTC_1288 0973-0013 65.5 µM -0.616630728922258 0.241847155205886 no 2540 0.268739160609197 3555 4315430 SGTC_1885 st057546 99.9 µM -0.616784747108805 0.241793243854358 no 2541 0.268688356972578 3593 702008 SGTC_321 4534-3890 65.3 µM -0.617614549116 0.241502898540674 no 2542 0.268414725865976 3538 699746 SGTC_2646 retinol 96.75 µM -0.617964368931577 0.241380554363926 no 2543 0.268299413143325 3571 445354 A vitamin A analog and teratogen. SGTC_1128 3448-9350 235 µM -0.61876629722625 0.241100219214506 no 2544 0.268035163888866 3477 619386 SGTC_166 k072-0058 166.424 µM -0.619027884704806 0.241008812726286 no 2545 0.267948994636407 3572 5846229 SGTC_114 0364-0001 490.298 µM -0.619304775149473 0.240912079459111 no 2546 0.267857799650716 3532 4003655 SGTC_519 k048-0011 62.8 µM -0.620487686620275 0.240499060482472 no 2547 0.267468379130308 3535 6836379 SGTC_2734 clemastine 41.6 µM -0.620985587498091 0.240325331477357 no 2548 0.267304553031708 3492 26987 Clemastine is a selective histamine H1 antagonist. SGTC_2662 daunorubicin 22.37 µM -0.621381486087383 0.240187242214382 no 2549 0.267174325253097 3477 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_3093 9117344 49.47 µM -0.622289474241005 0.23987069971173 no 2550 0.266875770574071 3553 24824913 SGTC_450 aminopyrene 156 nM -0.622526873236363 0.239787975300616 no 2551 0.266797739451978 3534 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1721 st082152 9.2685 µM -0.624199144527008 0.239205694359145 no 2552 0.266248404311893 3536 5296051 SGTC_777 1315-0167 517 µM -0.625751554368869 0.238665841181517 no 2553 0.26573895617713 3532 4221767 SGTC_541 4513-1321 94 µM -0.62838325920645 0.237752186424679 no 2554 0.264876450554614 3485 747515 SGTC_2526 patulin 37.61 µM -0.628545918094772 0.237695778804948 no 2555 0.264823188034584 3600 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_314 1671-0008 2.74 µM -0.629106494855432 0.237501435605593 no 2556 0.264639669357761 3506 3913060 SGTC_2897 9048598 12.99 µM -0.63029996920058 0.237087967371876 no 2557 0.264249171571282 3519 6467404 SGTC_1201 1889-3372 45.9 µM -0.630396086057119 0.237054685787451 no 2558 0.264217735473125 3505 5392199 SGTC_316 k060-0003 58.6 µM -0.632349411614371 0.236378880551795 no 2559 0.263579291317278 3595 6152314 SGTC_747 3448-8087 38.7 µM -0.632794350354396 0.236225090537813 no 2560 0.263433973312216 3550 5168703 SGTC_2943 9068529 45.32 µM -0.633164021867884 0.236097358044925 no 2561 0.263313268867938 3599 3270634 SGTC_1926 methyl fluorone black 53.6 µM -0.633983019843062 0.235814505488856 no 2562 0.26304595183095 3447 72721 Reacts with homocysteine. SGTC_418 lividomycin a 100 µM -0.637047193356313 0.234757908635368 no 2563 0.262047051837348 3595 72394 An antibiotic. SGTC_485 niflumic acid 177 µM -0.641044165977053 0.233383603882263 no 2564 0.260746994183781 3594 4488 A COX2 inhibitor. SGTC_1717 st033143 58.0435 µM -0.641292144463714 0.233298487155969 no 2565 0.260666446032455 3612 674616 SGTC_2283 7944793 200 µM -0.642716035415157 0.232810081027756 no 2566 0.260204187050334 3559 2970533 SGTC_1667 st014849 34.6 µM -0.643322878610922 0.232602101681454 no 2567 0.260007306957452 3615 5348460 SGTC_3023 9089636 49.47 µM -0.643600627324213 0.232506945173441 no 2568 0.259917221680173 3663 17249241 SGTC_1778 st046819 58.9 µM -0.643898654991347 0.232404865190093 no 2569 0.259820577016685 3592 671715 SGTC_894 0960-0238 55.9 µM -0.643961019811083 0.232383507241293 no 2570 0.259800355646421 3574 6741907 YDL195W SEC31 SGTC_1385 3091-4834 14.1 µM -0.644819668897115 0.232089558515433 no 2571 0.259522027078474 3556 4072814 SGTC_190 3970-0790 3.722 µM -0.645031253956655 0.232017156581214 no 2572 0.25945346605991 3566 2832352 SGTC_1318 1280-3875 124 µM -0.647335530862301 0.231229474690797 no 2573 0.258707405296663 3572 373245 SGTC_1045 1348-1485 165 µM -0.648114087542511 0.230963674547858 no 2574 0.258455581522632 3631 6810614 SGTC_55 0767-0285 6.563 µM -0.64893762867371 0.230682702400113 no 2575 0.258189345810752 3573 3116166 SGTC_94 0334-0113 514.748 µM -0.649699345434732 0.230422993301992 no 2576 0.25794322340762 3538 6795178 SGTC_1418 3966-3099 2.4 µM -0.650696260933567 0.2300833397404 no 2577 0.257621288665044 3593 740335 SGTC_2084 5306078 60.6385 µM -0.650929037780588 0.230004071990258 no 2578 0.257546147903902 3546 679340 SGTC_1052 3253-3998 198 µM -0.650992580559471 0.229982436355117 no 2579 0.257525638165006 3581 5450317 SGTC_2673 kobusone 100 µM -0.651499074125036 0.229810021454472 no 2580 0.257362187285064 3649 6710676 An epoxy ketone and protein crosslinker. SGTC_1197 1601-0112 267 µM -0.651567257437447 0.229786816778774 no 2581 0.257340187920214 3585 7350313 SGTC_1098 clofazimine 15.1 µM -0.653741399207926 0.229047584193231 no 2582 0.2566392132203 3639 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_2872 9044037 25.97 µM -0.654914342852865 0.228649324891538 no 2583 0.256261452584438 3591 6465195 SGTC_2856 9022925 19.48 µM -0.655119473068908 0.228579715297206 no 2584 0.256195417718876 3595 4944862 SGTC_3110 9122132 49.47 µM -0.655295789159772 0.228519893100776 no 2585 0.256138665695998 3678 918317 SGTC_2885 9057732 51.95 µM -0.655782400098231 0.22835483676355 no 2586 0.25598207104618 3626 6471414 SGTC_534 k292-0788 63.4 µM -0.656157136160958 0.228227773580085 no 2587 0.255861512530719 3656 4146317 SGTC_1355 1499-0035 1.68 µM -0.65726353912356 0.227852853319281 no 2588 0.255505738187665 3612 1548538 SGTC_2186 6124449 200 µM -0.657633188630523 0.227727669644493 no 2589 0.255386931515758 3573 3834182 YLR033W RSC58 SGTC_2524 avocatin b 10.57 µM -0.6577428328744 0.227690545512563 no 2590 0.255351697016865 3551 6710748 SGTC_1220 1838-0075 193 µM -0.658047811998954 0.227587301419473 no 2591 0.255253704446114 3554 5529645 SGTC_2520 obtusaquinone 4.71 µM -0.658059102777297 0.227583479676496 no 2592 0.255250076993629 3673 5967872 SGTC_1793 st048256 72.231 µM -0.659257294973496 0.227178116753065 no 2593 0.254865280226183 3549 672022 SGTC_1277 0873-0036 22 µM -0.661273691989917 0.226496864816819 no 2594 0.254218404853327 3631 5965735 SGTC_881 0833-0569 170 µM -0.662857233653583 0.225962665278687 no 2595 0.253710996938246 3591 5418700 SGTC_952 1185-0122 232 µM -0.663705970565646 0.225676641759767 no 2596 0.253439258639376 3583 678600 SGTC_2395 5646831 180.19 µM -0.663977048358729 0.225585331982988 no 2597 0.25335250047491 3631 6808628 SGTC_997 3996-0078 137 µM -0.664516830226676 0.225403574270222 no 2598 0.253179790356745 3637 735687 SGTC_1116 jasmonic acid  1.58368 µM -0.664719376134495 0.225335393524346 no 2599 0.253114999180798 3662 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1747 st037496 66.6 µM -0.665396352465059 0.225107595378238 no 2600 0.252898508655209 3641 723305 SGTC_2328 6201408 200 µM -0.665600889486444 0.225038795670952 no 2601 0.252833118857279 3596 2890418 SGTC_1644 st010134 20.9 µM -0.666749990731439 0.224652496379974 no 2602 0.252465920579935 3613 3818134 SGTC_2684 capsaicin 100 µM -0.667026000922235 0.224559764665211 no 2603 0.252377762686198 3634 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_741 4582-0002 126 µM -0.668156232415054 0.224180265071905 no 2604 0.25201693510155 3599 2912688 SGTC_2376 9072922 81.32 µM -0.66825689336524 0.22414648365958 no 2605 0.251984812194141 3651 17087968 SGTC_903 1134-0042 114 µM -0.669057839714596 0.223877792309567 no 2606 0.251729291326424 3622 701009 SGTC_1600 coumarin 106 71.1 µM -0.669061946553412 0.223876415071082 no 2607 0.251727981500187 3666 100336 A hepatotoxic, DNA x-linker. SGTC_1907 st060210 83.7 µM -0.669843388055854 0.223614444380731 no 2608 0.251478815757076 3651 688793 SGTC_15 0266-0086 27.098 µM -0.670570394217006 0.223370879222332 no 2609 0.251247124020041 3707 1712902 YIL048W NEO1 SGTC_897 1000-0139 31.4 µM -0.67073780534715 0.223314813718012 no 2610 0.251193787266706 3608 6151020 SGTC_2765 myclobutanil 7.74 µM -0.671027253688972 0.223217897199543 no 2611 0.251101583902092 3646 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_465 cgp-37157 41 µM -0.671676355282113 0.223000644396747 no 2612 0.250894878608397 3551 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_127 0180-0333 59.125 µM -0.671715836029091 0.222987434168329 no 2613 0.250882308938273 3608 771601 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.671736844031668 0.222980405088061 no 2614 0.250875620658085 3674 804 An inhibitor of viral and cellular DNA polymerases. SGTC_3004 9076122 71.4286 µM -0.672307049112784 0.222789668030829 no 2615 0.250694121539288 3615 44782551 SGTC_1009 4106-0057 9.87 µM -0.672412131046902 0.22275452763506 no 2616 0.250660681026317 3654 2928005 SGTC_2019 4016004 108 µM -0.673640389403478 0.222344020691552 no 2617 0.25026998425679 3601 45595336 SGTC_3291 9121177 71.43 µM -0.673796801125612 0.222291775960413 no 2618 0.250220254431058 3581 17015612 SGTC_1888 azatryptophan 97.5 µM -0.675611262392955 0.221686220708754 no 2619 0.249643744533992 3598 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_1561 5-methoxyflavone 52.9 µM -0.675840294629758 0.221609850929606 no 2620 0.24957102416184 3601 94525 SGTC_2285 7945142 200 µM -0.676607694012562 0.221354074639218 no 2621 0.249327448070996 3646 2970608 SGTC_490 phenamil 164 µM -0.677739228170529 0.220977239395375 no 2622 0.248968524618129 3574 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_1567 st069303 68.4 µM -0.677907299899728 0.220921297742686 no 2623 0.248915235607768 3674 5581319 SGTC_675 1309-0189 238 µM -0.67873272946916 0.220646676237629 no 2624 0.248653612127652 3620 4246530 SGTC_851 0394-0702 453 µM -0.682484393585924 0.219400959650691 no 2625 0.247466353885068 3646 762646 SGTC_645 0845-0943 5.41 µM -0.684257945393898 0.218813472449171 no 2626 0.24690614887544 3638 1885106 SGTC_3020 9089140 49.47 µM -0.685057865510692 0.218548796215628 no 2627 0.246653703447709 3655 17217859 SGTC_1702 st027038 51 µM -0.685330567621523 0.218458607146217 no 2628 0.246567673459269 3654 5521182 SGTC_503 tyrphostin 8 294 µM -0.685599745005117 0.218369604811842 no 2629 0.246482771191351 3628 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_2882 9058044 58.44 µM -0.68832397918227 0.217470024720508 no 2630 0.245624392270059 3617 18076804 SGTC_1657 st012939 43.4 µM -0.689536008163048 0.21707048448478 no 2631 0.245243010747962 3671 24207257 SGTC_1301 naphtanilide LB 4.81 µM -0.689643530747458 0.21703506061347 no 2632 0.245209192675274 3696 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_844 0330-0132 15.3 µM -0.68974811603798 0.217000607654026 no 2633 0.24517630084793 3662 2828079 SGTC_3103 9120822 49.47 µM -0.689866712746364 0.216961542814548 no 2634 0.245139005333447 3723 17141819 SGTC_1813 st051246 8.6015 µM -0.690703258320237 0.216686106643325 no 2635 0.244876020655568 3611 5291959 SGTC_1828 st055811 49 µM -0.693746474853205 0.215685822365074 no 2636 0.243920607435611 3626 5877589 SGTC_1840 st055363 71 µM -0.696359779591871 0.214828987617408 no 2637 0.243101772288793 3628 676033 SGTC_1293 1000-1278 195 µM -0.696785283486489 0.214689663379634 no 2638 0.24296858865008 3702 678847 SGTC_2972 9093619 59.92 µM -0.698108886273052 0.214256607323078 no 2639 0.242554550593984 3684 25236256 SGTC_3140 9094243 49.47 µM -0.698386961010604 0.214165691530901 no 2640 0.242467614238795 3700 19291112 SGTC_2331 7980721 200 µM -0.698964122171809 0.213977061894572 no 2641 0.242287226391535 3658 2981221 SGTC_2185 6113692 200 µM -0.699237937122763 0.21388760666152 no 2642 0.242201672810613 3660 874150 SGTC_1178 0988-0033 191 µM -0.699301730043848 0.213866768668044 no 2643 0.242181743041564 3684 5392207 SGTC_183 3914-0051 30.55 µM -0.69963832036508 0.213756840825359 no 2644 0.242076602406753 3666 1596232 SGTC_2816 7982706 58.44 µM -0.702383530094986 0.212861505692377 no 2645 0.24122000682797 3685 2981853 SGTC_221 trifluoperazine 10.304 µM -0.702728514583835 0.212749145912285 no 2646 0.241112476982837 3685 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.705658475591121 0.211796268550165 no 2647 0.240200274997188 3642 5711223 A potent inhibitor of glutathione S-transferases. SGTC_2262 9014885 67.46 µM -0.70632206345801 0.211580804889532 no 2648 0.239993937822382 3620 6457424 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.707407958639718 0.211228497098531 no 2649 0.239656496259481 3686 6312947 SGTC_3051 9093778 49.47 µM -0.707791739552272 0.21110406548684 no 2650 0.239537298430639 3701 17217378 SGTC_3174 9107204 49.47 µM -0.708225690198535 0.21096341932593 no 2651 0.239402557473103 3699 3938802 SGTC_386 1509-0011 3.07 µM -0.708976689968153 0.210720145378398 no 2652 0.239169471125193 3720 3107280 SGTC_1407 3909-7909 12.3 µM -0.709391601877008 0.21058581213607 no 2653 0.239040748922259 3689 4411780 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.709932112215517 0.210410890126722 no 2654 0.238873117903064 3702 688664 SGTC_3162 9099653 49.47 µM -0.710829981849376 0.21012050674838 no 2655 0.238594799520875 3669 25237511 SGTC_2203 7227154 166.4 µM -0.711073906063805 0.210041658989539 no 2656 0.238519219444178 3694 896304 SGTC_1612 st002233 45.4 µM -0.712578122339036 0.209555809950547 no 2657 0.238053426794545 3709 1035021 SGTC_2003 4023581 200 µM -0.712968082798456 0.209429964029327 no 2658 0.23793275383609 3724 16641307 SGTC_1050 3232-1156 69.3 µM -0.713443435718094 0.209276620872516 no 2659 0.237785701617602 3675 700529 SGTC_128 0906-2981 13.371 µM -0.71413542714038 0.209053510896168 no 2660 0.237571720593044 3660 6740226 SGTC_329 k048-0121 21.3 µM -0.714673295225156 0.2088801897361 no 2661 0.237405471371054 3690 6832902 SGTC_2967 9089538 49.85 µM -0.715026132762025 0.208766538317353 no 2662 0.237296447798266 3691 728216 SGTC_279 1273-0055 2.93 µM -0.715703959320461 0.208548307953383 no 2663 0.237087082759669 3738 2847562 SGTC_1021 4476-0760 85.3 µM -0.715811744042824 0.208513618408038 no 2664 0.237053799893277 3703 746768 SGTC_857 0438-0306 1.35 µM -0.715934044462095 0.208474261236769 no 2665 0.237016037831685 3730 4686136 SGTC_804 1595-0054 20.9 µM -0.717170969095646 0.208076456088835 no 2666 0.236634304938308 3681 761523 Stimulates phospholipase C. SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.717564019219815 0.207950141799727 no 2667 0.236513074819354 3785 5282309 SGTC_786 4544-0069 423 µM -0.718689699250711 0.207588633257475 no 2668 0.236166065737472 3752 748821 YLR208W SEC13 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.71948056673847 0.20733487094756 no 2669 0.235922435862265 3720 23847180 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.719784697305966 0.207237334705439 no 2670 0.235828784122133 3561 6708630 An antioxidant. SGTC_466 geldanamycin 89.2 µM -0.71984365725077 0.207218429087634 no 2671 0.23581063080051 3597 5288382 HSP90 inhibitor. SGTC_1645 Cervolide 78 µM -0.721941329527018 0.206546470446717 no 2672 0.235165274896178 3668 23173 A fragrance. SGTC_1762 st045503 25.4615 µM -0.722268705744341 0.20644171682192 no 2673 0.235064644570768 3772 4645554 SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.72236890523747 0.206409661347107 no 2674 0.235033849569872 3724 5377381 SGTC_176 1486-1328 72.834 µM -0.724121388316391 0.205849490056439 no 2675 0.23449560739499 3757 22310231 SGTC_1468 k284-1086 134 µM -0.725559089510507 0.205390611206617 no 2676 0.234054554212254 3718 15996457 SGTC_704 1310-0270 142 µM -0.725592097488716 0.205380083011327 no 2677 0.234044433532895 3686 5718033 SGTC_636 0kpi-0074 126 µM -0.72580192960165 0.205313162643361 no 2678 0.23398010192131 3733 616434 SGTC_3067 9117431 49.47 µM -0.727695284418732 0.204709913464907 no 2679 0.233400068805893 3740 17150885 SGTC_2742 clothiapine 36.27 µM -0.727889836999567 0.204647986098983 no 2680 0.233340512455765 3661 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_3027 9089541 49.47 µM -0.728455580301171 0.204467969623797 no 2681 0.233167375287875 3694 9943819 SGTC_1139 k015-0024 46.9 µM -0.729277872116201 0.204206488900113 no 2682 0.232915852538687 3696 2766652 SGTC_2460 5552655 174.22 µM -0.730074006211502 0.203953515910286 no 2683 0.232672474585132 3693 5401989 SGTC_365 0121-0052 13.6 µM -0.731572887953991 0.203477750679929 no 2684 0.232214650703685 3746 3101739 SGTC_2270 7924575 90.91 µM -0.732078152709429 0.20331752216716 no 2685 0.232060433854146 3735 1262135 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.734348690657152 0.202598423788495 no 2686 0.231368124796938 3736 66535 A nucleotide analog. SGTC_2483 5729050 27.16 µM -0.735086095764664 0.202365208842502 no 2687 0.231143530860545 3746 2865180 SGTC_2949 9072542 2.23 µM -0.735215331103005 0.202324352852778 no 2688 0.231104181754709 3790 16457352 SGTC_1802 st050112 57.9 µM -0.735393784652329 0.202267945306948 no 2689 0.231049853012505 3731 4662563 SGTC_965 1291-5240 308 µM -0.735826022694191 0.202131357780533 no 2690 0.230918291179069 3708 2834598 SGTC_2916 7875993 68.79 µM -0.736229146591024 0.202004020095838 no 2691 0.230795628626264 3697 1299250 SGTC_1927 st060202 13.8 µM -0.737479538050115 0.201609355368956 no 2692 0.230415391062697 3682 688887 SGTC_694 1315-0438 43.2 µM -0.737575854665199 0.201578973846089 no 2693 0.230386116213632 3701 6793154 SGTC_1173 0443-0020 122 µM -0.740706452048511 0.200592971537318 no 2694 0.22943572321497 3745 5331295 SGTC_1847 st056231 15 µM -0.741546611618481 0.200328851418643 no 2695 0.229181040370601 3745 5393180 SGTC_2115 tiliquinol 12.7705 µM -0.74174087550282 0.200267810630555 no 2696 0.229122174515774 3740 71208 A bioactive hydroxyquinoline. SGTC_3163 9099914 49.47 µM -0.743486361160217 0.199719852901939 no 2697 0.228593637931162 3742 16268368 SGTC_979 1426-2828 121 µM -0.744067953558852 0.199537474991573 no 2698 0.228417682789262 3850 747872 SGTC_2992 9074591 71.4286 µM -0.744315631641238 0.19945983761844 no 2699 0.228342773297999 3727 17741321 SGTC_3117 9124945 49.47 µM -0.745203867824203 0.199181559958832 no 2700 0.228074242505934 3673 17592065 SGTC_3099 9120367 49.47 µM -0.74656106108479 0.198756813530747 no 2701 0.227664280218098 3761 24824940 SGTC_2895 9054447 58.44 µM -0.746908854079045 0.198648056399121 no 2702 0.227559290505005 3779 2697450 SGTC_700 3453-2283 142 µM -0.747676314872152 0.198408193425927 no 2703 0.227327710421491 3805 565664 SGTC_2298 7976326 193.81 µM -0.748009309995963 0.198304173179641 no 2704 0.227227270989872 3644 2235818 SGTC_2845 9003024 42.97 µM -0.748610920033982 0.198116327095629 no 2705 0.22704587418858 3758 2990173 SGTC_2064 5220758 200 µM -0.749425572447838 0.197862132195677 no 2706 0.226800371272753 3791 788518 SGTC_2220 6782180 200 µM -0.750387507333837 0.197562234764839 no 2707 0.22651067637196 3674 833803 SGTC_2884 9058502 51.95 µM -0.752043511322424 0.197046595190969 no 2708 0.226012446385911 3740 6471554 SGTC_1159 4092-0538 61.2 µM -0.754411405807813 0.196310706743909 no 2709 0.225301112443083 3783 717301 SGTC_1471 k673-0312 37 µM -0.7544961571621 0.196284398845197 no 2710 0.225275675999348 3753 24099884 SGTC_734 2023-0417 80 µM -0.755474655497861 0.195980815330229 no 2711 0.224982116878234 3736 3935732 SGTC_3256 9138902 49.47 µM -0.755833469203142 0.19586956317936 no 2712 0.224874523590888 3782 17228773 SGTC_264 promethazine 12.5 mM -0.758284833296264 0.195110530069602 no 2713 0.224140242434609 3765 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1565 sinapyl alcohol 95.1 µM -0.758993620935858 0.194891396815905 no 2714 0.223928186373249 3774 5280507 A phenol propionate derived from cinnamic acid. SGTC_276 colchicine 750 µM -0.759251970433295 0.194811561090359 no 2715 0.223850921373718 3810 2833 A microtubule depolymerizer. SGTC_2716 st080858 38.6235 µM -0.760456032790813 0.194439741571456 no 2716 0.223491020441294 3757 5296050 SGTC_1012 4112-3522 18 µM -0.761982271003739 0.193969054121006 no 2717 0.223035292765065 3746 3112398 SGTC_1690 st023502 41.2 µM -0.765492264291066 0.192889219882241 no 2718 0.221989235541777 3746 24207482 SGTC_1957 st077035 62.4 µM -0.765522648510727 0.192879888367815 no 2719 0.221980192604719 3817 705593 SGTC_778 3456-2434 196 µM -0.767471991008971 0.192281788356993 no 2720 0.221400469986208 3816 5539063 SGTC_1729 st035615 45.989 µM -0.768654021627833 0.191919669140814 no 2721 0.221049363290378 3861 17385451 SGTC_1782 st039423 80.636 µM -0.769616259297922 0.191625192706035 no 2722 0.220763778636144 3809 2068169 SGTC_522 1273-0010 11.6 µM -0.769724802910107 0.191591992162737 no 2723 0.220731577003606 3868 5705015 SGTC_1432 4049-0298 68.4 µM -0.773376345114078 0.190477138551315 no 2724 0.219649842583192 3790 741646 SGTC_1547 harmine 94.2 µM -0.773391994193526 0.190472369313842 no 2725 0.219645213253772 3811 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_2117 5521686 200 µM -0.776511068433823 0.189523259680528 no 2726 0.218723644038467 3761 803312 SGTC_843 0310-0051 143 µM -0.776881944581521 0.189410598900843 no 2727 0.218614212306104 3822 2065037 SGTC_493 zm226600 134 µM -0.777001151028781 0.189374396399286 no 2728 0.218579045619784 3801 5240098 A potassium channel opener. YCR052W RSC6 SGTC_2495 cafestol 54.53 µM -0.779528041481322 0.188607992594071 no 2729 0.217834362916033 3785 16667697 An anti-infammatory. SGTC_1713 st033146 12.748 µM -0.779730394658008 0.188546701849823 no 2730 0.217774792136506 3759 674619 SGTC_2143 5623677 140.463 µM -0.78001983668249 0.188459054118216 no 2731 0.217689599595467 3753 5375313 SGTC_97 0535-0701 19.132 µM -0.780411265143474 0.188340563218182 no 2732 0.217574419600368 3726 2832013 YGL099W LSG1 SGTC_3326 9140064 16.379 µM -0.780564095254177 0.188294311871871 no 2733 0.217529458041657 3769 1868434 SGTC_2118 5526350 200 µM -0.781167496631123 0.188111771510325 no 2734 0.217351993934736 3844 743594 SGTC_1750 st081859 2.357 µM -0.782477189603484 0.187715940510873 no 2735 0.216967092854279 3791 5291695 SGTC_2437 5741531 144.16 µM -0.78391479820705 0.187282042145916 no 2736 0.216545052991476 3836 2262990 SGTC_3057 9095946 49.47 µM -0.78446146222119 0.187117211129786 no 2737 0.216384693145037 3802 24540043 SGTC_925 2064-1272 59.6 µM -0.784481472752459 0.18711117922493 no 2738 0.216378824507954 3802 6815817 SGTC_2139 5578692 56.4705 µM -0.7847453540065 0.1870316470293 no 2739 0.216301442711259 3740 650991 YMR113W FOL3 SGTC_227 fluconazole 33.516 µM -0.784831247559955 0.187005763749835 no 2740 0.216276258332614 3797 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_1034 k072-0165 12.7 µM -0.785760125479167 0.186725996002951 no 2741 0.216004015587223 3794 5835461 SGTC_2167 5876490 200 µM -0.786093715966586 0.186625585505657 no 2742 0.215906292771731 3967 686534 SGTC_2532 xanthone 78.9 µM -0.786475133109637 0.186510820192645 no 2743 0.215794590895141 3757 7020 An insecticide. SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.787001420891368 0.186352536264158 no 2744 0.215640517191834 3764 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_655 k060-0012 42 µM -0.787712717009908 0.186138742355274 no 2745 0.215432382649936 3807 5994525 SGTC_223 busulfan 5 mM -0.788001453997166 0.186052000225519 no 2746 0.21534792769902 3817 2478 A DNA alkylator. SGTC_2077 5212015 200 µM -0.78840241628014 0.185931585033144 no 2747 0.215230678956272 3711 780900 SGTC_3155 9099265 49.47 µM -0.789573632143589 0.185580127574443 no 2748 0.214888406155638 3827 25236499 SGTC_2247 cerulenin 830 nM -0.789922060115799 0.185475651221255 no 2749 0.214786643605047 3832 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2336 9001819 198.65 µM -0.790280793993273 0.185368122786587 no 2750 0.214681900350868 3833 2989602 SGTC_2778 tioconazole 65.09 nM -0.793295482803382 0.184466016892021 no 2751 0.213802844014198 3766 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2369 9071472 200 µM -0.795152166777327 0.183911789879321 no 2752 0.213262496197215 3913 17296037 SGTC_2160 5660466 132.927 µM -0.795453105820588 0.183822056226092 no 2753 0.213174989436656 3755 2859134 SGTC_2282 7944268 200 µM -0.798093052370749 0.183036049397045 no 2754 0.212408246461769 3818 2970414 SGTC_2850 9015429 58.44 µM -0.79822232218593 0.182997615063901 no 2755 0.212370742917954 3891 6457570 SGTC_1676 st018489 23.4 µM -0.800414371399849 0.182346644720936 no 2756 0.21173537858683 3883 3696235 SGTC_3227 9130768 49.47 µM -0.800458932182756 0.182333426579395 no 2757 0.21172247421423 3859 17720899 SGTC_2719 novobiocin 32.65 µM -0.801626335789118 0.18198735096557 no 2758 0.211384569407911 3809 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_623 k072-0108 16.9 µM -0.801874371704249 0.181913873909568 no 2759 0.211312816153893 3833 5382803 SGTC_2689 tacrolimus 100 µM -0.802193406833044 0.181819391646009 no 2760 0.211220544821296 3850 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_545 4218-0007 221 µM -0.802335807948735 0.181777229461054 no 2761 0.211179367195312 3800 2840508 SGTC_2870 9038528 12.99 µM -0.802380460022648 0.181764010115085 no 2762 0.211166456282171 3860 6463316 SGTC_552 k242-0005 476 µM -0.804683385968145 0.181083039290185 no 2763 0.210501204654544 3900 4088318 SGTC_1074 carmofur 3.8 µM -0.805403778259728 0.180870349274288 no 2764 0.210293356084134 3870 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1261 0712-0010 12.7 µM -0.805892074182484 0.18072627291149 no 2765 0.210152540827595 3817 2840123 SGTC_1831 st055328 12 µM -0.807125756331312 0.180362583903363 no 2766 0.209797017195465 3808 1103068 SGTC_1700 st030840 7.9285 µM -0.80821028121534 0.180043245964688 no 2767 0.209484770080129 3900 5499307 SGTC_665 3914-0008 307 µM -0.810846829348497 0.179268397015255 no 2768 0.20872681892735 3809 1069549 SGTC_2157 5649910 96.377 µM -0.815391362819451 0.177937745896907 no 2769 0.207424163368214 3825 2858091 SGTC_702 1488-0190 94 µM -0.815574910366288 0.177884133892824 no 2770 0.207371652044399 3885 949357 SGTC_45 0kpi-0036 14.9 µM -0.815609137258376 0.177874137761414 no 2771 0.207361860903905 3868 2795021 SGTC_1058 3448-5425 97.3 µM -0.816207769790551 0.177699361490206 no 2772 0.207190656857224 3745 7279705 SGTC_2254 7938975 95.19 µM -0.816291466529043 0.177674934094451 no 2773 0.207166726932477 3906 2969277 SGTC_1326 1431-2094 10.8 µM -0.817481468243339 0.177327854191471 no 2774 0.206826667731302 3827 616278 SGTC_618 k072-0232 33.2 µM -0.817530978704567 0.177313423086294 no 2775 0.206812526606014 3905 5872756 YGL099W LSG1 SGTC_2044 5102272 200 µM -0.82124971675442 0.176231620838447 no 2776 0.205752021421984 3871 592666 SGTC_277 nystatin 15.5 µM -0.821991465867153 0.176016342476339 no 2777 0.205540877008322 3840 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_291 SEC14.278 35.5 µM -0.822040788523492 0.17600203343376 no 2778 0.20552684150956 3852 1068044 SGTC_228 caffeine 993.056 µM -0.825935066744946 0.174874586020645 no 2779 0.204420463567336 3850 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1866 st057638 64 µM -0.827007502199993 0.174564907833225 no 2780 0.204116404638707 3847 688802 SGTC_1246 0422-0085 105 µM -0.8274598016637 0.174434405588546 no 2781 0.203988248648243 3900 264295 SGTC_3334 9142812 21.919 µM -0.830562230124331 0.173540931081908 no 2782 0.203110489561482 3927 45283678 SGTC_204 PMA1.184 62.41 µM -0.830869617161791 0.173452564932421 no 2783 0.203023644584577 3900 2252213 YGL008C PMA1 SGTC_311 1315-0136 58 µM -0.831882036203141 0.173161722118603 no 2784 0.202737766224013 3955 6759207 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.832178067225135 0.173076738488118 no 2785 0.202654220947795 3935 5379071 SGTC_2473 5854593 8.94 µM -0.832471527754119 0.17299251901377 no 2786 0.202571421422536 3792 2872951 SGTC_1380 2291-0730 164 µM -0.8326171883178 0.172950725964908 no 2787 0.20253033098541 3923 2999191 SGTC_2714 st079313 56.9 µM -0.834863719865513 0.172306964175935 no 2788 0.201897221986335 3854 2939799 SGTC_2217 6934799 96.0675 µM -0.835560061533227 0.172107732610921 no 2789 0.201701222419095 3809 675606 SGTC_2837 9008476 45.46 µM -0.835937724180721 0.171999740393267 no 2790 0.201594969244145 3864 2992805 SGTC_814 3342-0569 96 µM -0.835974185053217 0.171989316737252 no 2791 0.20158471296634 3918 4346283 SGTC_29 0299-0004 12.984 µM -0.836783935248713 0.171757924365684 no 2792 0.201357014487629 3766 16871 A napthoquinone isolated from Swertia calycina. SGTC_977 1348-1378 135 µM -0.837999796142796 0.1714108563448 no 2793 0.201015408995415 3875 X977 SGTC_3046 9092212 49.47 µM -0.838905304569771 0.171152670010229 no 2794 0.200761225430946 3923 25236637 SGTC_3338 9144300 39.5675 µM -0.84079502741811 0.170614657549263 no 2795 0.200231386673776 3910 4901274 SGTC_2059 5238311 157 µM -0.84098591376933 0.170560371632918 no 2796 0.200177912900972 3884 703021 SGTC_1160 4092-0570 10.5 µM -0.84134901476957 0.170457140350643 no 2797 0.200076219628835 3875 4994975 SGTC_671 0560-0003 407 µM -0.841813916976623 0.170325024943655 no 2798 0.199946060358319 3805 3238678 SGTC_1873 rapamycin 2 nM -0.843899107336302 0.169733264959913 no 2799 0.199362893533719 3865 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_212 3807-4682 38.772 µM -0.84554726271599 0.169266466085147 no 2800 0.198902678062948 3975 3125501 YBL034C STU1 SGTC_2996 9066192 71.4286 µM -0.848812288446489 0.16834416501092 no 2801 0.197992875622334 3971 6472854 SGTC_2647 atorvastatin 60.16 µM -0.850420974725055 0.167890935794693 no 2802 0.197545539450014 3890 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_1887 st057648 70.8 µM -0.853019160974236 0.167160586613452 no 2803 0.196824339273064 3929 688672 SGTC_1917 st066507 28.5 µM -0.854205198441078 0.166827873866934 no 2804 0.196495651676806 3893 3156428 SGTC_728 3030-5151 22.5 µM -0.854214030989421 0.166825397723087 no 2805 0.196493205153379 3934 3125388 SGTC_2512 diallyl trisulfide 49.23 µM -0.854802121393015 0.16666058399075 no 2806 0.196330351800469 3927 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_687 k029-0044 34.9 µM -0.856027641778789 0.166317466760296 no 2807 0.195991245042632 3972 5829338 SGTC_1352 1496-0991 99 µM -0.856656391397641 0.166141608663852 no 2808 0.195817405317823 3901 3000039 SGTC_1995 st072814 61.1 µM -0.859367957609325 0.165384573955375 no 2809 0.195068771009053 3907 5769371 SGTC_1618 st003135 44.5 µM -0.860731829013485 0.165004643375988 no 2810 0.194692879300548 3829 1270615 SGTC_1810 st050138 53 µM -0.860809461925589 0.164983034363403 no 2811 0.194671496436048 3867 3444541 SGTC_478 N-arachidonylglycine 10 µM -0.860928912532534 0.16494978903289 no 2812 0.194638598282178 3838 5283389 SGTC_446 go6976 132 µM -0.861740496973679 0.164724024830737 no 2813 0.194415167613186 3926 3501 A protein kinase C inhibitor. SGTC_790 1575-0012 79.1 µM -0.86290173660639 0.164401342866031 no 2814 0.194095747897687 4003 378741 YLR208W SEC13 SGTC_2782 7736369 71.43 µM -0.863022757980158 0.164367737385096 no 2815 0.194062477211347 3965 2950836 YOL077C BRX1 SGTC_2480 5767542 37.17 µM -0.863113463542511 0.164342552985284 no 2816 0.194037543098319 3895 2867358 SGTC_330 1488-0319 80.1 µM -0.863571432610382 0.164215436077345 no 2817 0.19391168148232 3965 6846614 SGTC_1514 1189-1591 158 µM -0.864837813804217 0.163864263014529 no 2818 0.193563906630505 3968 767698 YMR146C TIF34 SGTC_2507 purpurin 79.67 µM -0.865457174470888 0.163692689180484 no 2819 0.193393955805133 3919 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_2836 9010338 19.48 µM -0.866130972127591 0.163506167837408 no 2820 0.193209171056528 3935 2994051 SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.869192084517426 0.162660526296434 no 2821 0.192371038088126 3874 140250 A respiratory chain inhibitor. SGTC_1849 st056239 19.2 µM -0.86998914104161 0.162440804709013 no 2822 0.192153169267617 3940 5393181 SGTC_383 2324-0395 7.37 µM -0.87050549254015 0.162298567170647 no 2823 0.19201210945545 3954 3146421 SGTC_1374 2889-5571 141 µM -0.871035810232454 0.162152566836855 no 2824 0.191867300265171 3965 2853281 SGTC_2349 9023730 187.07 µM -0.871590110454081 0.162000055379421 no 2825 0.191716013857088 3941 4126287 SGTC_2193 5925765 200 µM -0.871862701978472 0.16192508819473 no 2826 0.191641641641222 3915 877370 SGTC_73 0327-0325 16.231 µM -0.872067449974751 0.16186879396965 no 2827 0.19158579106426 3862 53298 SGTC_732 3970-1727 52.7 µM -0.872091805817274 0.16186209832657 no 2828 0.191579148010322 3988 1275699 SGTC_3106 9121286 49.47 µM -0.873318145005138 0.161525199801837 no 2829 0.191244846535449 3958 15943471 SGTC_1933 st074711 15.9 µM -0.876381843895287 0.160685543127226 no 2830 0.190411242617338 3914 17250958 SGTC_2464 5717415 7.67 µM -0.87652416145368 0.160646608084141 no 2831 0.190372573649215 3928 5285744 SGTC_3008 9078912 71.4286 µM -0.885632041617339 0.158167703149144 no 2832 0.187907919793618 3925 16648731 SGTC_1944 st076371 56.9 µM -0.888543367001207 0.157380646739665 no 2833 0.187124269545415 3946 24208455 SGTC_1075 aripiprazole 15.2 µM -0.892537782745685 0.156304980693416 no 2834 0.18605237531373 3981 60795 An atypical antipschotic. YIL048W NEO1 SGTC_3317 9138495 8.753 µM -0.893509076763883 0.156044152225935 no 2835 0.185792306761775 3896 17020139 SGTC_2004 4023728 41.89 µM -0.893530504467535 0.156038401328489 no 2836 0.185786571936369 3964 360084 YDR527W RBA50 SGTC_2423 st077119 87.2 µM -0.894141761099532 0.155874407381593 no 2837 0.185623023885191 3883 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_806 3966-4455 5.86 µM -0.894787351898119 0.155701325349106 no 2838 0.185450386404896 3949 714982 SGTC_2783 7738165 71.43 µM -0.895508229271137 0.155508208919627 no 2839 0.185257734352833 3976 17201110 SGTC_1176 0848-0131 83.3 µM -0.895574385614235 0.155490494162383 no 2840 0.185240060520866 4012 6769040 SGTC_858 0438-0351 2.77 µM -0.896161441527014 0.155333355877573 no 2841 0.185083272944609 3950 2799119 SGTC_2745 rifampicin 24.3 µM -0.899150355707794 0.154534933628512 no 2842 0.184286289593972 3965 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_731 3966-0296 387 µM -0.899419624576726 0.154463137844208 no 2843 0.184214595016794 3969 660956 SGTC_861 0443-0273 110 µM -0.900357278445319 0.154213301121374 no 2844 0.183965074107086 3986 6149169 SGTC_2661 dactinomycin 12.96 µM -0.900360582511304 0.154212421229859 no 2845 0.183964195227876 3950 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_3096 9117468 49.47 µM -0.903787294488421 0.153301655771432 no 2846 0.183054100078726 3893 41316311 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -0.904625789534309 0.153079340965162 no 2847 0.182831833959529 3982 165521 SGTC_518 1021-0119 62.6 µM -0.905650687768972 0.152807894432684 no 2848 0.182560385456195 3953 1097762 SGTC_1382 3002-2117 298 µM -0.907407411338165 0.152343365299052 no 2849 0.182095695821854 4051 1497314 SGTC_491 tetrandrine 80.3 µM -0.907621784750399 0.152286742933564 no 2850 0.182039040297215 3997 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_767 0929-0023 86 µM -0.907792060896842 0.152241777918576 no 2851 0.181994046841632 4013 1204563 SGTC_306 1672-3436 11.6 µM -0.909455606774587 0.151802947220065 no 2852 0.181554840431501 4021 6797378 SGTC_1732 st034308 51.822 µM -0.91021034220064 0.151604131217351 no 2853 0.181355795477097 3849 830119 SGTC_1510 1123-0200 71.5 µM -0.911411268321894 0.151288134514011 no 2854 0.181039359289942 4044 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2082 5219693 150 µM -0.912890888092078 0.150899408642548 no 2855 0.180649965136541 3966 2834649 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.913547771265261 0.150727045505089 no 2856 0.180477260492457 4020 279621 SGTC_1378 2093-0007 380 nM -0.914143807957154 0.1505707616893 no 2857 0.180320642976401 4060 3618014 SGTC_549 1661-1316 519 µM -0.915416489943907 0.15023741946443 no 2858 0.179986512405089 3997 2857282 SGTC_960 1222-0186 7.7 µM -0.916297468908558 0.150006960798064 no 2859 0.179755447601273 4036 3126296 SGTC_328 k915-0120 63.5 µM -0.917160437036737 0.149781442306096 no 2860 0.179529287483484 3980 6624543 SGTC_810 3825-7150 143 µM -0.918836331556057 0.149344129055798 no 2861 0.179090592981884 4064 22330411 YGL099W LSG1 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.918846855466278 0.149341385609138 no 2862 0.179087840298087 4030 368090 SGTC_3040 9091894 49.47 µM -0.918878973212665 0.149333013137989 no 2863 0.179079439592814 3869 25236966 SGTC_168 3970-0862 530.542 µM -0.919258139403298 0.149234195581882 no 2864 0.178980283771349 3972 3135186 SGTC_672 1441-0018 53.7 µM -0.919590622001387 0.149147580552452 no 2865 0.178893364619951 3983 251141 SGTC_1972 st070201 17.4 µM -0.919698848642274 0.14911939367878 no 2866 0.178865077239008 3973 2829099 SGTC_2119 5528445 120.635 µM -0.920037304033266 0.14903126829549 no 2867 0.178776632748756 4012 791935 SGTC_230 MPP+ 141.667 µM -0.920620914933729 0.148879392233725 no 2868 0.178624189387694 3986 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_210 3551-0445 56.827 µM -0.921875875635721 0.148553157782627 no 2869 0.178296661995495 4035 2865180 YOR207C RET1 SGTC_1850 st056238 17 µM -0.922084141933785 0.148499064006015 no 2870 0.178242344007744 4002 5393177 SGTC_2961 9083290 32.55 µM -0.922656553238204 0.148350457356633 no 2871 0.178093106994902 3925 17741490 SGTC_736 0958-0254 92.6 µM -0.926175570488604 0.147439053178092 no 2872 0.177177373018781 4095 6812352 SGTC_1947 st076332 61.6 µM -0.930648945366499 0.146285902963039 no 2873 0.176017593610979 3920 24208416 SGTC_733 4069-0007 56.1 µM -0.930786721747683 0.146250483258449 no 2874 0.175981949798512 3999 5717425 YNL287W SEC21 SGTC_2833 9001315 45.46 µM -0.93160007334762 0.146041503292877 no 2875 0.175771622605613 3987 2989378 SGTC_2853 9015042 58.44 µM -0.931856330762629 0.145975702911508 no 2876 0.175705389182802 3924 6457456 SGTC_1863 st057641 20.1 µM -0.932245795548335 0.145875736417345 no 2877 0.175604756676872 4023 3921635 SGTC_1931 st074438 57.1 µM -0.934486508402519 0.145301491787937 no 2878 0.175026496103703 3980 2787313 SGTC_525 k781-2675 26.7 µM -0.936266106778422 0.144846505487049 no 2879 0.174568097087977 3983 3651118 YDL195W SEC31 SGTC_603 3794-0023 45.9 µM -0.936664478635191 0.144744786118378 no 2880 0.174465586742361 4026 3802260 SGTC_2307 7538926 6.34 µM -0.936844150872226 0.144698924761602 no 2881 0.17441936541008 4027 96582 SGTC_2345 9052315 157.45 µM -0.937785571174881 0.144458787132905 no 2882 0.174177308810071 4064 6469265 SGTC_280 3448-3607 3.04 µM -0.938655649003932 0.144237086472137 no 2883 0.1739537856188 3991 626179 SGTC_1768 st044301 37.178 µM -0.939192936175676 0.144100297328453 no 2884 0.173815847554663 4023 3931349 SGTC_1289 0976-0073 69.1 µM -0.940593684521092 0.143744089084093 no 2885 0.173456559788276 4067 3391136 SGTC_396 dithiazanine 1.25 µM -0.941115343138188 0.143611584028073 no 2886 0.173322876799584 4011 10578 An antihelmenthic. SGTC_954 1189-0853 2.85 µM -0.941564809761857 0.143497482394798 no 2887 0.173207746733913 3958 2828194 SGTC_3198 9112019 49.47 µM -0.941816192340478 0.143433693085945 no 2888 0.173143376780462 4071 45595555 SGTC_574 1315-0397 40 µM -0.946659497718614 0.142208422950224 no 2889 0.171906157650711 4013 6794277 SGTC_2396 5342950 42.78 µM -0.948310680617444 0.141792326771807 no 2890 0.171485657567835 4026 1886677 SGTC_1096 rimcazole 32.2 µM -0.951080509038379 0.141096186506241 no 2891 0.170781754098463 3957 18528119 A dopamine reuptake inhibitor. SGTC_91 0417-1751 58.384 µM -0.951284922269269 0.141044903372861 no 2892 0.170729879420325 4153 6795624 SGTC_1192 1488-0095 21.4 µM -0.951636723994363 0.140956673058116 no 2893 0.170640625052985 4090 915875 SGTC_1313 1220-0047 237 µM -0.952006541861539 0.14086396474468 no 2894 0.170546832084593 4015 3528706 SGTC_1127 asiatic acid 681.4 nM -0.952194358139617 0.140816897598683 no 2895 0.170499210882987 3993 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_3280 9140961 49.47 µM -0.95329718007319 0.140540743434781 no 2896 0.170219759934513 4076 4901226 SGTC_2145 5634607 200 µM -0.95420365941124 0.140314030255991 no 2897 0.169990281336811 3998 308662 SGTC_3050 9093513 49.47 µM -0.954364645787232 0.140273793070366 no 2898 0.169949547786494 4013 25236664 SGTC_2929 9013348 24.6 µM -0.954866767671715 0.140148342288426 no 2899 0.169822538681076 4056 2995952 SGTC_2255 7941087 197.44 µM -0.959256397194516 0.13905487735366 no 2900 0.168714797693351 4137 935561 SGTC_907 3448-6986 75.5 µM -0.96033388445516 0.138787363372573 no 2901 0.168443600798686 4077 590582 SGTC_1063 disulfiram 1.84 µM -0.968970096666581 0.136655866060407 no 2902 0.166280054663552 4047 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_444 curcumin 90.4 µM -0.97100546727352 0.136156794396626 no 2903 0.165772778018518 4007 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1798 st045719 60.953 µM -0.971554958851211 0.136022273495935 no 2904 0.165635999592741 3927 3980186 SGTC_2677 mitomycin C 100 µM -0.971757952059482 0.135972601798791 no 2905 0.165585489364527 4080 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_3130 9127414 49.47 µM -0.975982329239878 0.134941729885724 no 2906 0.164536610610774 4071 1494646 SGTC_1515 3460-0031 42.1 µM -0.977299262648684 0.134621458500665 no 2907 0.164210509014123 4002 2876596 SGTC_1131 3454-3128 32.3 µM -0.979208896869232 0.134157972750392 no 2908 0.163738386775065 4115 710982 SGTC_1430 4049-0248 69.1 µM -0.981709689882829 0.133552666723518 no 2909 0.163121445149254 4079 22774488 SGTC_1575 cyproterone acetate 48 µM -0.983361659922356 0.133153846225277 no 2910 0.162714736489806 4084 9880 An androgen receptor antagonist and liver toxin. SGTC_282 k297-0036 65.7 µM -0.983685662471358 0.133075721400817 no 2911 0.162635045745001 4076 5061378 SGTC_2880 9042983 58.44 µM -0.983820351298236 0.133043253963753 no 2912 0.162601925537015 4075 6464714 SGTC_1102 cgs 12066b 26.1 µM -0.986019953577329 0.132513800037665 no 2913 0.162061660705432 4073 6438352 A 5-HT1B full agonist. SGTC_3179 9107801 49.47 µM -0.986724776333534 0.132344453647183 no 2914 0.161888790231821 4077 4818259 SGTC_175 3793-3120 23.7 µM -0.987869776475697 0.132069664788361 no 2915 0.161608214535808 4085 5322297 SGTC_1448 4255-0083 152 µM -0.989199044185631 0.131751147328829 no 2916 0.161282882990919 4160 5399660 SGTC_1815 st051655 58.2 µM -0.992033603683749 0.131073705043793 no 2917 0.160590566689505 4039 5984156 SGTC_1620 st003704 16.5 µM -0.995601299249915 0.130224473448162 no 2918 0.159721951624886 4018 2834414 SGTC_2030 5175110 200 µM -0.995925610736233 0.130147465597268 no 2919 0.159643145283419 4121 2831986 SGTC_2982 9019404 25.97 µM -0.996861675850698 0.12992537344581 no 2920 0.159415828092008 4027 22333232 SGTC_249 wiskostatin 11.211 µM -0.997871482324727 0.129686079657539 no 2921 0.15917084102985 4022 2775510 A n-wasp and actin depolymerizer. SGTC_622 1348-1566 26.3 µM -1.00274369818697 0.128535801216943 no 2922 0.157992270055409 4117 7340407 SGTC_2040 5100729 123 µM -1.00278200306836 0.12852678598474 no 2923 0.157983027003365 4101 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_928 2764-0428 58.7 µM -1.00282785461251 0.128515995187398 no 2924 0.157971963391856 4122 662578 SGTC_1367 1812-0510 76.9 µM -1.00332583798564 0.128398839249397 no 2925 0.157851836745057 4119 1142582 YDR527W RBA50 SGTC_3237 9133362 49.47 µM -1.00510526968775 0.127980814729282 no 2926 0.157423081448257 4069 43845137 SGTC_1911 st060208 74.3 µM -1.00544583960854 0.127900915885248 no 2927 0.157341108241387 4139 688783 SGTC_1711 st032263 62.8 µM -1.00559836083004 0.127865145135059 no 2928 0.157304406365658 4099 3958979 SGTC_290 2043-6722 48.1 µM -1.00688636651284 0.12756334683183 no 2929 0.156994692164899 4115 773758 YLR208W SEC13 SGTC_1406 3909-7906 11.9 µM -1.00731938946159 0.127461994644134 no 2930 0.156890657507329 4107 X1406 SGTC_1233 0325-0408 14.2 µM -1.00758437412108 0.127400000673099 no 2931 0.156827016772162 4138 12874 SGTC_492 tmb-8 126 µM -1.00763852776567 0.127387333843586 no 2932 0.156814012911004 4032 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2034 5197015 53.07 µM -1.00794497066847 0.127315671698694 no 2933 0.156740440447966 4111 780676 SGTC_2194 5927483 104.545 µM -1.01166261209939 0.126448528804682 no 2934 0.155849698867873 4118 760979 SGTC_2740 felodipine 17.08 µM -1.01176359199617 0.126425032701871 no 2935 0.155825550876068 4114 3333 L-type calcium channel blocker SGTC_739 1486-1183 203 µM -1.01528090229445 0.12560851913494 no 2936 0.154985972640861 4118 4346692 SGTC_3212 9128307 49.47 µM -1.01872623622243 0.124812288665538 no 2937 0.154166476684607 4065 27243542 SGTC_3318 9139014 38.6185 µM -1.01938166493182 0.124661216635106 no 2938 0.154010903613783 4105 16643984 SGTC_1533 dihydroergotamine mesylate 29.4 µM -1.02190943767826 0.124079778708978 no 2939 0.153411882609056 4208 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_3053 9095903 49.47 µM -1.02428828217437 0.123534332792058 no 2940 0.15284956547728 4212 17174018 SGTC_2202 7226349 200 µM -1.02478733883544 0.123420117384 no 2941 0.152731770899248 4068 844334 SGTC_180 1486-1293 102.781 µM -1.0271381375992 0.122883102454506 no 2942 0.152177711357162 4005 4140536 SGTC_1426 4048-4480 71.7 µM -1.02734667914584 0.122835542602872 no 2943 0.15212862474809 4109 14224343 SGTC_2466 5983409 37.09 µM -1.02774124132495 0.122745594323414 no 2944 0.152035781281985 4131 2879657 SGTC_682 0kpi-0099 17 µM -1.02824689861197 0.122630387262448 no 2945 0.151916851327158 4150 1714895 YML126C ERG13 SGTC_1136 pergolide 1.05886 µM -1.0288257111804 0.122498605913852 no 2946 0.151780791225578 4082 47811 A dopamine receptor agonist. SGTC_2586 curcumin 80 µM -1.02890471538627 0.122480626314608 no 2947 0.151762226176277 4069 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2123 5259487 200 µM -1.02939944404032 0.12236807918658 no 2948 0.151646005135197 4138 2173474 SGTC_3293 9120939 62.045 µM -1.02979103025762 0.122279047682083 no 2949 0.151554056141666 4129 934087 SGTC_1633 st005664 67.9 µM -1.03110141211591 0.121981448427395 no 2950 0.151246632839454 4117 2063822 SGTC_1290 0986-0249 10.2 µM -1.03121907037058 0.121954752111971 no 2951 0.15121904982897 3990 53329 SGTC_2433 5607874 27.82 µM -1.03272731752414 0.121612898662343 no 2952 0.150865762896538 4091 2252428 SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.03281758292733 0.1215924608365 no 2953 0.15084463685966 4161 23665772 A membrane-active detergent. SGTC_608 k048-0125 159 µM -1.0333626423703 0.12146910017947 no 2954 0.150717111054748 4172 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_1208 2323-2347 50.3 µM -1.03517464983292 0.121059629853547 no 2955 0.150293677644412 4143 5412760 SGTC_1915 st067105 30.6 µM -1.03603760444896 0.120864964493741 no 2956 0.1500922996835 4071 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_443 clozapine 122 µM -1.03838800672865 0.120335878033178 no 2957 0.14954472543974 4063 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1254 0550-0035 264 µM -1.0387363806523 0.120257596490302 no 2958 0.149463678203488 4189 15121435 SGTC_501 nsc-95397 161 µM -1.03874650020711 0.120255323106842 no 2959 0.149461324384175 4170 262093 SGTC_1393 3470-5649 58.2 µM -1.03925776401694 0.120140505810424 no 2960 0.149342436075326 4106 4108395 SGTC_359 0081-0058 15.9 µM -1.04010044817219 0.119951428278687 no 2961 0.149146617740243 4241 3494159 SGTC_424 splitomicin 100 mM -1.04039755638113 0.119884814569694 no 2962 0.14907761826592 4196 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3225 9130819 49.47 µM -1.04211010512456 0.119501357738476 no 2963 0.148680317043315 4061 4547121 SGTC_3112 9123419 49.47 µM -1.04346900029158 0.119197703791752 no 2964 0.148365565454969 4177 17015854 SGTC_2412 st077135 33.4 µM -1.04531346787465 0.118786417463649 no 2965 0.147939057551943 4231 13258915 SGTC_1419 3993-2473 62.6 µM -1.04567263808036 0.118706445087069 no 2966 0.147856099922225 4204 704026 SGTC_467 ro 31-8220 72.8 µM -1.04813150514552 0.118159978407229 no 2967 0.147289011353478 4077 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_1943 st076331 65.2 µM -1.05034128392021 0.117670389846978 no 2968 0.146780615354694 4152 24208415 SGTC_2421 5690543 90.72 µM -1.05056678519 0.117620509663953 no 2969 0.146728801352904 4154 3397993 SGTC_1693 xanthone 101.9 µM -1.05063857858637 0.117604632328393 no 2970 0.146712307776959 4187 7020 An insecticide. SGTC_2377 9073351 62.6 µM -1.05224340988722 0.117250114775414 no 2971 0.146343943873566 4119 7337946 YHR072W ERG7 SGTC_1908 st060353 56.5 µM -1.05297347918327 0.117089088535544 no 2972 0.146176573584745 4208 4227716 SGTC_889 0919-1524 82.7 µM -1.05400625277643 0.116861564647483 no 2973 0.145940027205886 4175 3905452 SGTC_2327 6189656 200 µM -1.05718686801547 0.116162832449061 no 2974 0.145213155934023 4222 5349088 SGTC_1137 ixabepilone 100 µM -1.05736617865809 0.116123529140597 no 2975 0.145172250440137 4106 154225 A novel microtubule stabilizer. SGTC_3217 9129673 49.47 µM -1.05885192056359 0.115798230717155 no 2976 0.144833611785452 4195 17248312 SGTC_392 N-ethylmaleimide 8.33 µM -1.0618569528999 0.115142267872456 no 2977 0.144150314960196 4090 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1945 st075991 56.6 µM -1.06271501498432 0.114955448953577 no 2978 0.143955604785131 4165 1084980 SGTC_159 3970-0959 50 µM -1.06607662128203 0.114225630569961 no 2979 0.143194503454118 4231 6615653 SGTC_2288 7946289 167.31 µM -1.06809839369649 0.113788287834052 no 2980 0.142738065189452 4231 1246052 SGTC_1664 st014217 9.02 µM -1.07120451587574 0.113118709738585 no 2981 0.14203874077497 4215 3982782 SGTC_2138 5575593 77.673 µM -1.0727200544502 0.112793031820731 no 2982 0.141698369822302 4157 762213 SGTC_366 0181-0206 4.31 µM -1.08296145984941 0.110609769825568 no 2983 0.139412765001922 4215 274874 SGTC_1953 st076800 12.1 µM -1.08378550853811 0.110435424988566 no 2984 0.139229955975774 4168 297591 SGTC_3010 9080089 71.4286 µM -1.08438567524047 0.11030857115858 no 2985 0.139096916201522 4200 17027233 SGTC_2086 5274770 176.623 µM -1.09450087120705 0.10818628331122 no 2986 0.136867682744747 4215 689278 SGTC_1493 4348-0038 111 µM -1.09517379960024 0.108046144906624 no 2987 0.136720250899982 4160 800424 SGTC_105 0111-0055 734.78 µM -1.09550257719411 0.107977723998936 no 2988 0.136648258532232 4192 5179370 SGTC_600 1495-0418 41.6 µM -1.09604117938572 0.107865704560955 no 2989 0.136530376934219 4175 5377768 SGTC_1258 0671-0043 57.1 µM -1.09677114943769 0.107714017720808 no 2990 0.136370722492369 4215 4298767 SGTC_2033 5192550 145 µM -1.09749979758866 0.107562758885286 no 2991 0.13621148459131 4197 182073 SGTC_2489 cantharidin 73.42 µM -1.09958244886408 0.107131268947974 no 2992 0.135757046261184 4142 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3158 9100007 49.47 µM -1.10180852654432 0.106671445187838 no 2993 0.135272461355379 4218 19297233 SGTC_5 0352-0601 109.883 µM -1.10459604588881 0.106097659600967 no 2994 0.134667332602308 4114 762456 SGTC_697 0508-1955 564 µM -1.10591508827405 0.105826925252458 no 2995 0.134381636737523 4191 6243113 SGTC_2962 9082311 13.18 µM -1.11271381590778 0.104439400026811 no 2996 0.132915679965432 4183 16459453 SGTC_1296 1068-0102 11.9 µM -1.1179126004757 0.103387329162667 no 2997 0.131802161460117 4210 767053 SGTC_1559 coumarin 343 70.1 µM -1.11913093318829 0.103141893433912 no 2998 0.131542142491415 4238 108770 A hepatotoxic, DNA x-linker. SGTC_1519 esterone 74 µM -1.11925071240399 0.103117786519368 no 2999 0.131516598104634 4175 698 A steroid. SGTC_1078 idebenone 36.1 µM -1.11985240561297 0.102996750898707 no 3000 0.131388331452125 4256 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_2403 6032726 181.2 µM -1.12021918196745 0.10292302141343 no 3001 0.131310185860002 4264 2881040 SGTC_867 0518-0118 155 µM -1.12058940724199 0.102848637519573 no 3002 0.131231337994156 4190 6848158 SGTC_1255 0566-0045 221 µM -1.12120246131094 0.102725551530065 no 3003 0.131100846145951 4222 2788469 SGTC_2717 st081029 62.2815 µM -1.12373309995609 0.102218595354112 no 3004 0.130563134976816 4188 5292846 SGTC_3113 9123498 49.47 µM -1.12601227619744 0.101763573745781 no 3005 0.130080161566493 4319 8897275 SGTC_2129 girgensonine 121.053 µM -1.1276615650527 0.101435225555252 no 3006 0.129731437750159 4227 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2444 5485484 36.41 µM -1.12943159370743 0.101083699161893 no 3007 0.129357905694424 4293 6790631 SGTC_3258 9138477 49.47 µM -1.13194088369243 0.100586878838932 no 3008 0.128829644434251 4246 4970355 SGTC_2513 baicalein 25.65 µM -1.13260578129107 0.10045553320548 no 3009 0.128689919873142 4239 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_3001 9076041 71.4286 µM -1.13331905811425 0.100314769792597 no 3010 0.128540145625163 4199 16004211 SGTC_84 0443-0269 128.823 µM -1.13424142358595 0.100132956765315 no 3011 0.128346646267134 4143 6150058 SGTC_3165 9101544 49.47 µM -1.13525536916691 0.0999333695490439 no 3012 0.128134168144109 4237 5002184 SGTC_1010 4112-3296 15.2 µM -1.1364886183194 0.0996910059358042 no 3013 0.127876063152851 4288 704384 SGTC_2721 ifenprodil 61.44 µM -1.14059227529132 0.098887629425465 no 3014 0.127019816654809 4237 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_1284 0929-0043 16 µM -1.14080729017379 0.0988456667526039 no 3015 0.126975063107246 4235 1239883 SGTC_3035 9091303 49.47 µM -1.1414335817951 0.0987235128577821 no 3016 0.126844768296436 4301 25237002 SGTC_2320 7373003 200 µM -1.1424824218439 0.0985191912823786 no 3017 0.126626774292212 4278 5415828 SGTC_2867 9039098 71.43 µM -1.14503393951115 0.098023430333919 no 3018 0.126097549231374 4199 6463460 SGTC_792 4534-1957 155 µM -1.1463100644636 0.0977761655956192 no 3019 0.125833440018123 4199 1717904 SGTC_2476 5806916 10.51 µM -1.14664241130411 0.0977118444624587 no 3020 0.125764720263282 4112 2870194 SGTC_2087 5276107 200 µM -1.14872403912037 0.0973096797402326 no 3021 0.125334895068645 4200 144405 SGTC_217 ketoconazole 989 nM -1.14921667165429 0.0972146824581049 no 3022 0.125233324017987 4066 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_668 1682-0499 62.6 µM -1.14989924805188 0.0970831696569838 no 3023 0.125092685319432 4214 682214 SGTC_1359 1582-0056 520 nM -1.1531001891789 0.0964681823143622 no 3024 0.124434632005205 4300 3661189 SGTC_2440 5628896 157.78 µM -1.15741931333642 0.0956429053260663 no 3025 0.123550543567907 4219 5522048 SGTC_1311 1190-0148 100 µM -1.15810017652684 0.0955132847746582 no 3026 0.123411578992049 4297 1961333 SGTC_1529 apigenin 74 µM -1.15965855632887 0.0952170921248413 no 3027 0.123093924979176 4274 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3210 9128157 49.47 µM -1.16025781631118 0.0951033743183922 no 3028 0.122971926874869 4253 17590849 SGTC_1807 st050092 58.9 µM -1.16744757844882 0.0937468094354505 no 3029 0.121514833272091 4280 5008496 SGTC_3016 9080866 49.47 µM -1.1698379175946 0.09329897926989 no 3030 0.121033100688399 4231 17066299 SGTC_109 0132-0036 33.701 µM -1.17437684646729 0.0924529642826936 no 3031 0.120122057537856 4071 67274 A color developer. SGTC_3249 9135183 49.47 µM -1.17470627868973 0.0923917827775798 no 3032 0.120056123279375 4245 4902779 SGTC_2683 piperine 63.03 µM -1.17698696177944 0.0919690402805171 no 3033 0.119600355150725 4245 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_147 4466-0538 29.23 µM -1.17877481802205 0.0916386499547783 no 3034 0.119243927108543 4372 6742687 YHR072W ERG7 SGTC_61 0978-8327 98.565 µM -1.18040763684861 0.0913376791615376 no 3035 0.118919063015368 4182 6150059 YHR072W ERG7 SGTC_439 amiodarone 34.4 µM -1.18063097869484 0.0912965685147666 no 3036 0.118874675773181 4127 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_516 3992-2719 87.3 µM -1.18227429180913 0.090994504773667 no 3037 0.11854844141237 4183 5350887 YDR037W KRS1 SGTC_620 0109-0052 432 µM -1.18285447838562 0.0908880357020365 no 3038 0.118433412679828 4292 493037 SGTC_793 0488-0545 106 µM -1.18331509668512 0.0908035742441386 no 3039 0.118342145944237 4298 292548 SGTC_1204 4049-0315 18.3 µM -1.19123505383643 0.0893604253585641 no 3040 0.116780660960987 4328 588402 SGTC_361 000s-0510 1.45 µM -1.1914138066117 0.0893280516489394 no 3041 0.11674558772873 4203 660 SGTC_3281 9140613 49.47 µM -1.19152766432135 0.0893074355593069 no 3042 0.116723251505559 4278 16013766 SGTC_2815 7968870 71.43 µM -1.19156002054991 0.0893015774987229 no 3043 0.116716904522178 4225 2977326 YHR190W ERG9 SGTC_2462 5162487 171.77 µM -1.19195978321781 0.0892292244787217 no 3044 0.116638507442435 4239 2259986 SGTC_1207 2099-0101 141 µM -1.19410515604729 0.0888416786014275 no 3045 0.116218418296611 4271 5837381 SGTC_2983 9022671 12.99 µM -1.19642149104942 0.0884246582252289 no 3046 0.115766059423708 4271 6405161 SGTC_1882 5615643 20 µM -1.20007439267479 0.0877699760486454 no 3047 0.115055224846471 4234 2253075 SGTC_2114 5491910 81.25 µM -1.20210943170816 0.0874068230801319 no 3048 0.114660566308142 4335 2849228 SGTC_1631 benzylvanillin 81.9 µM -1.20257311788524 0.0873242353336886 no 3049 0.114570777783324 4349 75506 SGTC_284 0988-0104 32.6 µM -1.20269066190956 0.087303308673653 no 3050 0.114548024426795 4257 4666532 SGTC_3295 9122362 53.5725 µM -1.20883629258314 0.0862143945720205 no 3051 0.11336287274341 4298 4730473 SGTC_468 gf-109203x 121 µM -1.21150748806183 0.0857442785515113 no 3052 0.112850483283972 4310 2396 A protein kinase C inhibitor. SGTC_561 1550-0330 72.9 µM -1.21224191105847 0.0856153610118495 no 3053 0.112709896287949 4240 6812934 SGTC_975 1335-0046 28.5 µM -1.21427122114836 0.0852598989985658 no 3054 0.112322085734041 4304 16486740 SGTC_3148 9097893 49.47 µM -1.21750227564462 0.0846962181723628 no 3055 0.111706585568369 4266 17174100 SGTC_1436 4092-1007 8.32 µM -1.21876955974665 0.0844758959876753 no 3056 0.111465834056755 4282 2881121 SGTC_3077 9117319 49.47 µM -1.22936682842869 0.0826503243158217 no 3057 0.109467150737947 4281 17154678 SGTC_2095 5432005 200 µM -1.23110654030478 0.0823534863123709 no 3058 0.109141509860312 4311 783734 SGTC_1132 3456-3614 2.5 µM -1.23613477824244 0.0815000576449207 no 3059 0.108204234660581 4346 3125502 SGTC_738 1315-0003 72.4 µM -1.23654631873538 0.0814305044136056 no 3060 0.10812777984555 4341 6251474 SGTC_2698 st077697 67.5 µM -1.23718642933217 0.0813224102144452 no 3061 0.108008939229892 4280 3154499 SGTC_2813 7971799 71.43 µM -1.2373459005636 0.0812954974756432 no 3062 0.107979347017714 4320 2234054 SGTC_2015 5119600 184 µM -1.23885493023424 0.0810411626126765 no 3063 0.107699613530341 4346 2828786 SGTC_595 3909-8003 73.7 µM -1.24129979028611 0.080630376352236 no 3064 0.107247511071592 4384 699517 SGTC_477 mead ethanolamide 10 µM -1.24137429940545 0.0806178820429846 no 3065 0.107233754396568 4256 16061185 SGTC_3189 9110682 49.47 µM -1.24147481092212 0.0806010297522281 no 3066 0.107215198895129 4360 17122418 SGTC_1108 betulinic acid 729.144 nM -1.24369694559511 0.0802291342763798 no 3067 0.106805560288573 4313 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_49 0717-0965 32.132 µM -1.24519052482147 0.0799798992705168 no 3068 0.1065308623479 4390 5889349 YGL099W LSG1 SGTC_970 1315-0089 19.5 µM -1.24674665215134 0.079720849986068 no 3069 0.106245203518739 4271 6811083 YLR033W RSC58 SGTC_3171 9103192 49.47 µM -1.247302025527 0.0796285505509686 no 3070 0.106143387519053 4408 13018434 SGTC_1211 1056-0033 32.3 µM -1.24771911946247 0.0795592854352281 no 3071 0.106066968499065 4383 6741922 SGTC_24 0417-1663 219 µM -1.24817292040516 0.0794839763294326 no 3072 0.105983869264823 4353 4329390 SGTC_1324 1418-0026 34.4 µM -1.24935664962069 0.0792877881797354 no 3073 0.10576732827878 4365 1372513 SGTC_2309 7664088 163.95 µM -1.25051622460793 0.0790959589487511 no 3074 0.105555516133106 4333 704922 SGTC_892 0929-0076 29 µM -1.25092651358262 0.07902816882707 no 3075 0.105480644789125 4303 5751038 SGTC_1932 st074806 40.9 µM -1.25629212739044 0.078145679782482 no 3076 0.104505037589144 4386 17251235 SGTC_517 1365-0151 113 µM -1.25724911558763 0.0779890713193252 no 3077 0.10433172161831 4356 768657 SGTC_2350 9023895 38.85 µM -1.2574368278897 0.0779583806770349 no 3078 0.10429775031065 4333 2997209 SGTC_2200 6600604 21.907 µM -1.25888270848549 0.0777222887382031 no 3079 0.104036350169748 4366 2904777 SGTC_939 1165-0479 45.3 µM -1.26867582500333 0.0761374763626223 no 3080 0.102278354074409 4324 1377347 SGTC_581 0958-0271 211 µM -1.27063988970089 0.0758226155863851 no 3081 0.101928394565869 4349 4591145 SGTC_1978 st071761 42 µM -1.2728988887105 0.0754617010022914 no 3082 0.101526961830325 4366 5147680 SGTC_1161 k007-0610 110 µM -1.27556358051446 0.075037654652865 no 3083 0.10105491758759 4307 5843850 SGTC_72 0744-0168 198.391 µM -1.27607253293057 0.0749568694915075 no 3084 0.10096494004218 4235 677577 SGTC_1222 0366-0074 1.18 µM -1.27647520135247 0.0748930016289082 no 3085 0.100893793805676 4375 286520 SGTC_617 3770-0098 35 µM -1.28453795312702 0.073622876814894 no 3086 0.0994768963911894 4270 5962639 SGTC_157 1348-1695 65.819 µM -1.29187203116309 0.0724819034798689 no 3087 0.0982007325181697 4287 5380510 SGTC_2178 5812956 200 µM -1.29657620126799 0.0717572308538429 no 3088 0.0973885226960738 4320 5403383 SGTC_2195 6536160 144.242 µM -1.29849428849884 0.071463351440445 no 3089 0.097058768851612 4341 3834386 SGTC_1898 st060199 18.6 µM -1.30191071190072 0.0709421936382312 no 3090 0.0964734551030607 4342 688866 SGTC_1539 benzyladenosine 56 µM -1.30262456544371 0.0708336686005025 no 3091 0.0963514834336732 4364 92208 A nucleotide analog. SGTC_593 1203-0218 61.7 µM -1.30496038148032 0.0704794527898173 no 3092 0.0959531693661924 4400 3666956 SGTC_2506 ethyl hematommate 54.16 µM -1.30599119739076 0.0703235680079756 no 3093 0.0957777755378244 4413 3940691 An allergen. SGTC_1068 loratadine 26.9 µM -1.30714233794024 0.0701498006743426 no 3094 0.0955821872928213 4420 3957 A H1 histamine antagonist. SGTC_2659 sanguinarine 24.21 µM -1.30760635572042 0.0700798495849864 no 3095 0.095503430029774 4328 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_2448 5185112 27.17 µM -1.31406200086285 0.0691122131532131 no 3096 0.0944126701873731 4374 5718189 SGTC_1307 1187-1599 12.2 µM -1.31533362726288 0.0689228286482988 no 3097 0.0941989006867136 4372 1538471 SGTC_3118 9124250 49.47 µM -1.31593872416257 0.0688328515889483 no 3098 0.0940973050270368 4335 1504786 SGTC_1992 st073643 23.3 µM -1.32386668789946 0.0676623245701134 no 3099 0.0927736616657808 4364 3161292 SGTC_3095 9117207 49.47 µM -1.32410673697918 0.0676271238042417 no 3100 0.092733799228357 4370 17015229 SGTC_2461 5755302 26.15 µM -1.32605476255553 0.0673419886642546 no 3101 0.0924107794019959 4403 2788904 SGTC_2553 4-methylesculetin 85.09 µM -1.32789205750111 0.0670739137310358 no 3102 0.0921068844804129 4407 5319502 SGTC_391 gliotoxin 8.33 µM -1.33401817780492 0.066186028418174 no 3103 0.0910989496079006 4458 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.33509297152844 0.0660311969000363 no 3104 0.0909229597706454 4297 17037758 SGTC_3085 9117376 49.47 µM -1.33539162172165 0.0659882241215479 no 3105 0.0908741027327093 4475 16480349 SGTC_2295 7971645 200 µM -1.33850027542824 0.0655422056667845 no 3106 0.0903667053094525 4444 2978226 YKL099C UTP11 SGTC_283 0987-0079 11.7 µM -1.34000686285775 0.0653268886486466 no 3107 0.0901215568773609 4396 411556 SGTC_4 0960-0234 25.671 µM -1.34220672832542 0.065013476470581 no 3108 0.0897644877505187 4394 6821112 SGTC_2199 6590217 200 µM -1.34411733918889 0.0647422221332781 no 3109 0.0894552229843834 4310 703109 SGTC_2112 5488546 200 µM -1.3487931690541 0.0640820899682279 no 3110 0.0887017047111349 4363 600757 SGTC_1603 st002045 67.8 µM -1.34951233967377 0.0639810236692321 no 3111 0.0885862297709781 4399 5887985 SGTC_711 k292-0785 179 µM -1.35462022677533 0.0632667659392112 no 3112 0.0877692928657302 4336 4146315 SGTC_2678 equilin 100 µM -1.35506623703103 0.0632046943020818 no 3113 0.0876982272703724 4401 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_100 0086-0128 49.5915 µM -1.35729043214489 0.062895858742009 no 3114 0.0873444731188095 4410 93297 SGTC_2505 galangin 7.89 µM -1.3613549390274 0.0623345295961235 no 3115 0.086700774473142 4307 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_214 4373-3496 70 µM -1.36166899385367 0.0622913201448976 no 3116 0.0866511853444781 4497 3779166 SGTC_44 0929-0055 61.211 µM -1.36331837804386 0.0620647718775843 no 3117 0.0863910962298385 4285 1379590 SGTC_679 0422-0091 41.4 µM -1.36568942691635 0.0617402275732245 no 3118 0.0860182321644732 4449 627384 YHR062C RPP1 SGTC_1827 berberine 7.24 µM -1.36757071571869 0.0614836645125936 no 3119 0.0857232440478332 4308 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1269 0831-0796 3.05 µM -1.37251446171588 0.0608134239657903 no 3120 0.0849516700092104 4442 927758 SGTC_449 xestospongin c 11.1929 µM -1.37425903732974 0.0605782744404445 no 3121 0.0846806391730095 4437 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_3017 9080681 49.47 µM -1.37552888682078 0.0604075605148296 no 3122 0.084483768213828 4440 16451914 SGTC_432 NS 1619 61.3 µM -1.38312513289337 0.0593941987372774 no 3123 0.0833132502860798 4400 4552 A K+/calcium channel activator. SGTC_2817 7995342 71.43 µM -1.38339016460853 0.0593590848030394 no 3124 0.0832726323352843 4414 18879975 SGTC_2243 6634756 200 µM -1.38494683356856 0.0591531708556467 no 3125 0.083034362479881 4459 885676 SGTC_362 0310-0100 9.03 µM -1.38550075514388 0.0590800341916452 no 3126 0.0829497008815561 4464 790235 SGTC_2211 7117706 200 µM -1.38579985591208 0.0590405721229841 no 3127 0.0829040132041914 4367 822771 SGTC_811 0416-0114 265 µM -1.38589088869259 0.059028565754658 no 3128 0.0828901116946249 4451 6612453 SGTC_2469 5655019 90.81 µM -1.38782185673032 0.0587743401603058 no 3129 0.0825956487880984 4479 2788239 SGTC_1361 1608-0041 5.61 µM -1.39484391674045 0.0578570746809194 no 3130 0.0815314561638871 4412 X1361 SGTC_1868 st057644 42.7 µM -1.39705848435125 0.0575701399355285 no 3131 0.081197992389359 4456 688665 SGTC_1298 1079-1278 263 µM -1.39841302836392 0.057395188221129 no 3132 0.0809945365303986 4416 2840950 SGTC_1685 st024049 53.0905 µM -1.40290327559756 0.0568182221120017 no 3133 0.0803228419875375 4448 1941139 SGTC_442 cape 100 µM -1.40368102208983 0.05671875273277 no 3134 0.0802069280857679 4444 5281787 SGTC_1008 4106-0037 6 µM -1.40608263353499 0.0564124658013845 no 3135 0.0798497943033518 4461 2905394 SGTC_2751 anetholtrithion 17.25 µM -1.40649066742945 0.056360557434859 no 3136 0.0797892369656074 4401 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2649 anisomycin 9.56 µM -1.40783836954531 0.0561893759062791 no 3137 0.0795894679385077 4479 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2056 5235370 200 µM -1.40972296535688 0.0559506873323135 no 3138 0.0793107504225403 4358 5511916 SGTC_945 3381-0768 11.3 µM -1.41003565109018 0.0559111624079786 no 3139 0.0792645781120605 4448 1126236 YIL048W NEO1 SGTC_2439 5492030 7.2 µM -1.41068797893637 0.0558287760586298 no 3140 0.0791683185295433 4447 5722370 SGTC_1472 k841-0093 193 µM -1.41505480474687 0.0552797279392694 no 3141 0.0785262139811508 4544 X1472 SGTC_3056 9094900 49.47 µM -1.41673287548722 0.0550698790703981 no 3142 0.0782805206971235 4449 25236784 SGTC_2758 dehydroepiandrosterone 69.35 µM -1.41722398029946 0.0550085838195587 no 3143 0.0782087263949293 4433 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_3336 9143619 71.43 µM -1.41800921248604 0.0549106902764344 no 3144 0.0780940375759667 4456 45595730 SGTC_1404 3909-7820 48.3 µM -1.42229193023257 0.0543791923006899 no 3145 0.0774707602936066 4448 23741373 SGTC_8 0354-0001 70 µM -1.42565514272626 0.0539646672250741 no 3146 0.0769839553431971 4452 4993152 SGTC_1940 st075990 51.1 µM -1.42597535347229 0.0539253311586748 no 3147 0.0769377282402142 4493 1084979 SGTC_2073 5212005 126 µM -1.42796513314157 0.0536814066333608 no 3148 0.0766509472590109 4342 691789 SGTC_3276 9139060 49.47 µM -1.43461881808917 0.0528720823123716 no 3149 0.0756978745944404 4549 4870619 SGTC_3088 9117578 49.47 µM -1.43654916154574 0.0526391042117045 no 3150 0.0754230689340268 4520 678341 SGTC_440 fluspirilene 35.1 µM -1.43845634270151 0.0524097224465176 no 3151 0.0751523080340606 4488 3396 An atypical antipsychotic. SGTC_3329 9141233 27.5565 µM -1.43943217948302 0.0522926632313801 no 3152 0.0750140562484169 4427 4909101 YNL103W MET4 SGTC_583 1488-1091 88.9 µM -1.44041376902737 0.0521751234791135 no 3153 0.0748751852177222 4561 4303273 SGTC_1425 4048-4433 7.33 µM -1.44409504284919 0.0517361800380053 no 3154 0.0743561211555237 4528 23734946 SGTC_1487 3970-0795 2.82 µM -1.44529004468352 0.0515943245733726 no 3155 0.0741882165056769 4511 3765103 SGTC_2592 piperlongumine 83.33 µM -1.45764650963986 0.0501455861968759 no 3156 0.0724690014353562 4455 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1271 0832-2808 169 µM -1.45846278180327 0.050051035683523 no 3157 0.0723565133108595 4506 3663794 SGTC_2735 sertaconazole 140 nM -1.46321532255309 0.0495033588443726 no 3158 0.0717042346825996 4607 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_1812 st052057 4.327 µM -1.46754112681256 0.0490090267743118 no 3159 0.071114454999494 4491 3645418 SGTC_2335 9018011 154.17 µM -1.46906853606052 0.0488354267852586 no 3160 0.0709071004106632 4447 6458208 SGTC_748 act1.228 77.9 µM -1.47475733685467 0.0481931770911715 no 3161 0.0701388974716939 4466 4421505 YNR035C ARC35 SGTC_1796 st049173 110.4 µM -1.47752872596413 0.0478827523612794 no 3162 0.0697669819722064 4462 94134 SGTC_780 0109-0199 192 µM -1.47920795812654 0.0476954408357927 no 3163 0.0695423716385396 4516 610414 SGTC_2137 5261020 140 µM -1.47942262979833 0.0476715374439287 no 3164 0.0695136978230926 4468 763655 SGTC_3269 9137823 49.47 µM -1.48001638444532 0.047605473653521 no 3165 0.0694344370963981 4421 17682936 SGTC_1970 st070122 35.8 µM -1.48395728557448 0.0471688480109434 no 3166 0.0689101264000963 4496 102928 SGTC_1751 st044839 27.194 µM -1.4871810203827 0.0468140717292961 no 3167 0.0684835037154805 4535 5291326 SGTC_2130 NSC 7 2.4545 µM -1.49097924807491 0.0463988218413784 no 3168 0.0679834716558586 4532 21448 SGTC_3247 9135149 49.47 µM -1.49160455863373 0.046330742676223 no 3169 0.067901421219423 4543 8934436 YOR116C RPO31 SGTC_2213 7173844 200 µM -1.49359637250371 0.0461144232389791 no 3170 0.0676405740730007 4503 892728 SGTC_403 arphamenine a 50 µM -1.49549775112599 0.0459086830008944 no 3171 0.0673922931931428 4497 5487158 An arginine aminopeptidase inhibitor. SGTC_685 1278-0033 54.9 µM -1.49560164723011 0.0458974621238035 no 3172 0.0673787468258222 4551 3590572 SGTC_1024 4507-0395 26 µM -1.49809420542236 0.045628923509405 no 3173 0.0670543881981573 4525 4201836 SGTC_1319 1306-0155 43.7 µM -1.50619514510189 0.04476487312625 no 3174 0.0660085426926828 4521 3122360 SGTC_557 1315-0110 16.2 µM -1.50806128843466 0.0445677082385588 no 3175 0.0657694208768648 4478 6833801 SGTC_827 3253-0474 693 µM -1.50807866395608 0.0445658757433437 no 3176 0.0657671975907323 4491 5402065 SGTC_1249 0481-0015 10.2 µM -1.51671548520848 0.0436624869035156 no 3177 0.0646692664619269 4440 4227577 SGTC_1062 mesoridazine 14.2 µM -1.51847454040128 0.0434803180168167 no 3178 0.0644474064857405 4554 4078 A neuroleptic. SGTC_1248 0469-0687 58.6 µM -1.51907331375837 0.0434184488069602 no 3179 0.0643720215455199 4463 4017482 SGTC_1791 st048313 56.1 µM -1.52141294749805 0.0431773835100885 no 3180 0.0640781208757508 4514 1204976 SGTC_1067 clotrimazole 1.36 µM -1.52751585949109 0.0425536519953551 no 3181 0.063316393303608 4536 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2979 9012552 45.46 µM -1.53188755507974 0.0421113494514729 no 3182 0.0627750925226168 4521 17100905 SGTC_1764 st044502 93.5 µM -1.53263072090032 0.0420365316116187 no 3183 0.0626834338441002 4532 8407 SGTC_2204 7233102 200 µM -1.5331647159759 0.0419828383903032 no 3184 0.0626176377555269 4498 2172480 SGTC_2796 7949634 45.45 µM -1.53425597357505 0.0418732850632036 no 3185 0.0624833461100202 4479 2971588 SGTC_368 fentichlor 4.58 µM -1.53740687622235 0.0415582588185514 no 3186 0.0620968517824547 4510 7329 A pesticide. SGTC_848 0368-0089 85.6 µM -1.54737921424398 0.0405738638787403 no 3187 0.0608859152065077 4514 762535 SGTC_2397 5161689 200 µM -1.55167423749508 0.0401557633488017 no 3188 0.0603700950068331 4532 2259942 SGTC_2611 pyromycin 23.93 µM -1.55374644618413 0.0399552988267927 no 3189 0.0601224546961153 4466 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1909 st060837 51.5 µM -1.55633942570693 0.0397056015718252 no 3190 0.0598137004976341 4465 678937 SGTC_2688 kanamycin b 96.69 µM -1.55908360648489 0.0394427274919333 no 3191 0.0594882965915856 4501 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_62 0180-0423 3.232 µM -1.56388273432538 0.0389864075102663 no 3192 0.0589225549661872 4480 30102 YGL099W LSG1 SGTC_13 0199-0087 65 µM -1.56491094890034 0.0388892021113315 no 3193 0.058801895536515 4634 4589825 SGTC_1054 3429-0080 167 µM -1.56765570308351 0.0386306848127828 no 3194 0.0584807523802107 4536 1162877 SGTC_184 1494-0393 24.714 µM -1.5696606219223 0.0384427359698687 no 3195 0.0582470434727951 4514 3090647 SGTC_523 1934-0222 13.7 µM -1.57358094830324 0.0380773831115608 no 3196 0.05779218030127 4502 1361595 SGTC_2732 terfenadine 20 µM -1.57789852607388 0.0376782911088334 no 3197 0.0572944618383227 4611 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_710 3448-4187 58 µM -1.58615592925699 0.0369245358455105 no 3198 0.0563519710984202 4504 3946412 SGTC_2390 9097792 176.6 µM -1.58778349689992 0.0367774318133709 no 3199 0.0561676522490403 4557 4497149 SGTC_1999 st074831 12.5 µM -1.58829950701065 0.0367308935887409 no 3200 0.0561093144674933 4531 17112523 SGTC_1470 k295-0292 231 µM -1.60127869260004 0.0355760737498993 no 3201 0.0546576030780701 4595 5045612 SGTC_1171 0368-0077 21.4 µM -1.60556895565154 0.0352009580035482 no 3202 0.0541843255203703 4526 3239779 SGTC_2922 7999257 32.47 µM -1.62065635390625 0.0339074910516193 no 3203 0.0525456795282477 4516 2988377 SGTC_3289 9119912 71.43 µM -1.62167629735718 0.0338214792591976 no 3204 0.0524363382620072 4550 17014829 SGTC_57 miconazole 162.5 nM -1.62237720410118 0.0337624759406047 no 3205 0.0523613035408244 4388 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2252 omeprazole 400 µM -1.63149213640265 0.03300285156088 no 3206 0.0513932588859647 4598 4594 A proton pump inhibitor. SGTC_3303 9125618 40.5795 µM -1.6393132296718 0.0323623325803172 no 3207 0.050574021086707 4544 22695467 SGTC_3203 9113543 49.47 µM -1.64289734209683 0.0320722530862434 no 3208 0.0502020875269207 4565 17018012 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -1.64517858096661 0.031888741948545 no 3209 0.0499664946152881 4631 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2362 9071156 126 µM -1.64609528602062 0.0318152435523587 no 3210 0.0498720714114438 4566 653133 SGTC_567 1080-0542 68.4 µM -1.64832735397745 0.0316368687441179 no 3211 0.0496427572320389 4469 5950415 SGTC_2984 9022109 38.96 µM -1.65061542441352 0.0314548771570634 no 3212 0.0494085636499387 4583 6459207 SGTC_1395 3486-0190 4.35 µM -1.65320031255962 0.0312503189652517 no 3213 0.0491450514515118 4551 6748079 SGTC_1545 lovastatin 49.4 µM -1.6554864190842 0.0310703232074239 no 3214 0.0489129345104568 4604 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2342 7990637 118.86 µM -1.68386186852921 0.0289067385758129 no 3215 0.046104183558489 4566 2033102 YER133W GLC7 SGTC_584 0986-0246 15.4 µM -1.68729210336355 0.0286538839056683 no 3216 0.0457735993280823 4651 53315 YDR232W HEM1 SGTC_991 3996-0057 64.7 µM -1.6888777783784 0.0285376214104955 no 3217 0.0456214272840645 4607 715343 SGTC_2785 7756463 72.73 µM -1.68954680119147 0.0284886861645521 no 3218 0.045557345471958 4552 2201551 SGTC_1179 1021-1431 9.29 µM -1.69144210617993 0.0283504341787468 no 3219 0.0453761980756282 4597 2840958 SGTC_3272 9137413 49.47 µM -1.69657154935387 0.0279790676560913 no 3220 0.0448888462292331 4528 17614870 SGTC_2539 epi(13)torulosol 80 µM -1.69909513617188 0.0277978547461905 no 3221 0.0446506298432399 4553 6708597 SGTC_870 0573-2213 57.6 µM -1.71097955331655 0.0269575588481386 no 3222 0.0435424436982822 4590 3916321 SGTC_357 1325-0123 420 µM -1.71256610059851 0.0268470019567358 no 3223 0.0433961971364577 4580 1098503 SGTC_2381 9035592 200 µM -1.71352787809555 0.0267801659841298 no 3224 0.0433077345527762 4608 4749657 SGTC_2529 gangaleoidin 93.61 µM -1.71614066722692 0.0265992987940996 no 3225 0.0430681497851829 4571 4565183 SGTC_1692 fluoroquinolonic acid 71 µM -1.71848887279678 0.0264376188532849 no 3226 0.0428537411652859 4609 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_2375 9072683 200 µM -1.72372793113292 0.0260798549352914 no 3227 0.0423784851209296 4627 16798029 SGTC_994 3910-0338 138 µM -1.72607568401459 0.0259208507474654 no 3228 0.042166898868838 4620 3479481 SGTC_2221 6807166 181.081 µM -1.72863537774375 0.0257484176360892 no 3229 0.0419371868720041 4594 674925 SGTC_2373 9071805 200 µM -1.73837301845974 0.0251011929816172 no 3230 0.041072553882736 4602 10149009 SGTC_2406 ethylparaben 405.7 µM -1.74151549710321 0.0248952569017379 no 3231 0.0407966296151335 4544 8434 A possible steroid mimic. SGTC_135 0933-0004 26.348 µM -1.74563009910515 0.0246277584122188 no 3232 0.0404376242818528 4524 21230617 YGL099W LSG1 SGTC_967 1306-0166 352 µM -1.74663973594132 0.0245624896735792 no 3233 0.040349924978506 4601 4437607 SGTC_1310 1188-0297 994 nM -1.75178614676383 0.0242320477345314 no 3234 0.0399052935867493 4500 1588352 SGTC_1686 st019653 115.5 µM -1.75181226137637 0.0242303805294198 no 3235 0.0399030475745984 4603 97252 SGTC_3159 9100096 49.47 µM -1.7534182282679 0.0241280376052773 no 3236 0.0397651221869072 4572 25236875 SGTC_2191 5911152 200 µM -1.7553716311329 0.0240040434447774 no 3237 0.03959788063229 4622 2875902 SGTC_2666 tannic acid 100 µM -1.76017770544089 0.0237012507473139 no 3238 0.039188840422564 4589 16134267 A thiamine antagonist. SGTC_3222 9128301 49.47 µM -1.76457703383626 0.0234269056908712 no 3239 0.0388174390519069 4570 4911358 SGTC_1808 st050063 61.5 µM -1.77062235442092 0.0230542780328143 no 3240 0.0383117610246184 4566 4011993 SGTC_866 0495-0101 262 µM -1.77483026097384 0.0227978635337389 no 3241 0.0379629590637857 4616 635694 SGTC_140 0062-0056 502.533 µM -1.78445607630551 0.0222203261707043 no 3242 0.0371747930107684 4537 3758964 SGTC_1480 1070-0044 41.2 µM -1.78722157984546 0.0220567001616485 no 3243 0.0369508413980273 4661 3124987 SGTC_1144 3486-0183 12.5 µM -1.79695562125387 0.0214888357601211 no 3244 0.0361713326848936 4632 6744069 SGTC_2313 7726885 200 µM -1.79871682468389 0.0213874222704796 no 3245 0.0360317430645937 4610 726423 SGTC_1417 3966-0327 90.4 µM -1.79890519253384 0.0213765996793583 no 3246 0.0360168395413027 4684 651118 SGTC_2101 5377231 179.231 µM -1.80740952241013 0.020892788162923 no 3247 0.0353492251600126 4645 2844213 SGTC_23 0213-0011 39.996 µM -1.80939680173529 0.0207810775602169 no 3248 0.035194689844269 4619 627608 SGTC_1681 tripelennamine 100 µM -1.81093344326377 0.0206950456811077 no 3249 0.0350755774789801 4557 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1156 4092-0367 4.88 µM -1.81390378197657 0.0205296003530424 no 3250 0.034846270193266 4654 1357585 SGTC_2800 7887935 81.82 µM -1.81589246016624 0.0204194600746802 no 3251 0.0346934350690893 4613 2961002 SGTC_2308 7584454 197.62 µM -1.81924167296498 0.0202351002828795 no 3252 0.0344372838077841 4602 893577 SGTC_1166 k206-0078 225 µM -1.81937190773038 0.0202279600161921 no 3253 0.0344273547898016 4649 5404595 SGTC_2626 ethyl orsellinate 100 µM -1.82181046107999 0.0200946575714223 no 3254 0.0342418749561132 4565 75653 A natural product. SGTC_571 k831-0106 44.2 µM -1.83350849490042 0.0194655039640352 no 3255 0.0333634932147842 4544 4783639 SGTC_2131 toluylene red 5.2905 µM -1.83728295236902 0.0192661071967582 no 3256 0.0330840676123874 4595 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2686 alizarin 95.37 µM -1.84234560870503 0.0190013854101848 no 3257 0.0327123061894193 4607 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.84547475508174 0.0188393169902016 no 3258 0.0324842537523292 4609 6728940 SGTC_3206 9114350 49.47 µM -1.84725950223804 0.0187474070670639 no 3259 0.0323547696599681 4521 17087243 SGTC_2488 5268135 45.7 µM -1.85304522406765 0.018452076348345 no 3260 0.0319379384486257 4660 1270356 YLR208W SEC13 SGTC_1662 st014054 52 µM -1.8558194838259 0.018311876235216 no 3261 0.0317396462272799 4701 2838777 SGTC_393 acivicin 6.25 µM -1.86485243445901 0.0178616581616293 no 3262 0.0311010456114917 4521 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_1765 st044815 90.4 µM -1.8695908374272 0.0176292867715204 no 3263 0.0307703293123764 4652 645695 SGTC_909 3448-9333 149 µM -1.87647711666794 0.0172961856252907 no 3264 0.0302948970205552 4590 3344074 SGTC_1475 4092-1048 11.7 µM -1.88059264715651 0.0170996884935068 no 3265 0.0300136763625869 4656 2881759 SGTC_56 0957-0365 83.25 µM -1.88096271382299 0.0170821134201582 no 3266 0.0299884955497625 4599 6752360 SGTC_2625 euphol 100 µM -1.88559949411427 0.0168632104708058 no 3267 0.0296744728135655 4648 6708538 A triterpene alcohol. SGTC_2773 thioridazine 9.09 µM -1.88628667376584 0.0168309736259447 no 3268 0.0296281670415557 4644 5452 An antipsychotic. SGTC_1142 3253-1408 9.78 µM -1.88752646642821 0.0167729460192736 no 3269 0.0295447750011946 4648 256655 SGTC_1299 1079-1439 3.74 µM -1.90171164239016 0.0161211080937432 no 3270 0.02860443148701 4650 323161 SGTC_2777 climbazole 1.536 µM -1.91260018436173 0.0156355963802726 no 3271 0.0278996280326626 4443 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_3146 9095609 49.47 µM -1.91406771054202 0.015571129784897 no 3272 0.0278057523201626 4672 17173999 SGTC_2705 st078069 42.8 µM -1.91464149625745 0.0155459861937258 no 3273 0.0277691196401651 4658 1530061 SGTC_103 0844-0104 51.839 µM -1.91648016796671 0.0154656492356812 no 3274 0.0276520025874987 4480 5375804 SGTC_781 4335-2806 94.4 µM -1.92463822178925 0.0151134844841455 no 3275 0.0271373170902524 4683 845254 SGTC_2589 lobaric acid 100 µM -1.9250628701447 0.0150953435858561 no 3276 0.027110746682594 4591 73157 A novel microtubule depolymerizer. SGTC_2879 9041815 71.43 µM -1.92824492424291 0.0149600013200407 no 3277 0.0269123343801412 4694 4942971 SGTC_2023 5144124 124 µM -1.938696003279 0.0145228001878831 no 3278 0.0262691828093705 4641 2830192 SGTC_727 3032-0951 202 µM -1.94051644742733 0.0144477808658122 no 3279 0.0261584786423661 4701 3652836 SGTC_50 0929-0078 56.389 µM -1.94123806261602 0.0144181360355736 no 3280 0.0261147041498778 4536 1377751 SGTC_1387 3342-1166 1.8 µM -1.94476981184251 0.0142738016979426 no 3281 0.025901344483144 4682 3418228 SGTC_3082 9117008 49.47 µM -1.95013788116997 0.0140568050554799 no 3282 0.0255798436384127 4682 41448529 SGTC_1994 st072947 40.9 µM -1.96001205720387 0.0136650740977951 no 3283 0.0249971905221659 4695 5286565 YDL195W SEC31 SGTC_2062 5245942 200 µM -1.9669217493873 0.0133965853260591 no 3284 0.0245961163509747 4701 1376160 SGTC_1278 0874-0585 172 µM -1.97087106537681 0.0132451827810123 no 3285 0.0243693127428899 4704 766306 SGTC_1792 st045773 43.6 µM -1.97691935364904 0.0130161791077168 no 3286 0.0240253733999719 4657 2919270 SGTC_1362 1611-0397 101 µM -1.98301395284059 0.0127888923128142 no 3287 0.0236829355121034 4692 27816 SGTC_1494 4358-1428 177 µM -1.98391955016225 0.0127554144354789 no 3288 0.0236324045560411 4711 1564571 SGTC_2724 maprotiline 69.64 µM -1.99270793778905 0.0124344466295142 no 3289 0.0231467188398807 4622 4011 A tricyclic antidepressant. SGTC_435 c-PAF 6.7 µM -2.00458142167767 0.0120119287362547 no 3290 0.0225039072091808 4606 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_149 3970-0822 46.1 µM -2.0173921507674 0.0115700762501166 no 3291 0.0218273028737764 4665 3114250 YBL034C STU1 SGTC_17 0960-0276 49.807 µM -2.01773585419964 0.0115584186650813 no 3292 0.0218093893060406 4687 6821114 SGTC_1229 0139-0193 12.2 µM -2.01879366484214 0.0115226042800195 no 3293 0.0217543348992926 4719 3090752 SGTC_407 eburnamonine 100 µM -2.0204541058963 0.0114665809638556 no 3294 0.0216681530110284 4570 3195 SGTC_2051 5263410 176 µM -2.02108871944352 0.0114452316698167 no 3295 0.0216352909381088 4639 227584 SGTC_2801 7907800 81.82 µM -2.03050752974383 0.0111324056628461 no 3296 0.0211524882854322 4669 6620925 SGTC_1026 k007-1105 30.6 µM -2.04998519897481 0.0105090027270956 no 3297 0.0201829375885567 4653 7066794 SGTC_2066 5222451 176 µM -2.05874260154523 0.0102387730980854 no 3298 0.0197594514131224 4642 2281147 SGTC_31 0508-1974 57.237 µM -2.06924269631231 0.00992277460852323 no 3299 0.0192616589860747 4666 6810525 SGTC_2248 tofa 1.1 µM -2.07279231193133 0.00981789248344029 no 3300 0.0190958061206196 4716 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2730 imipramine 71.33 µM -2.07939953277528 0.00962524224882867 no 3301 0.0187903217107733 4683 3696 A tricyclic antidepressant. SGTC_3031 9088762 49.47 µM -2.0987609162419 0.00907961238873018 no 3302 0.017918990875521 4701 205253 SGTC_425 3825-7017 13.1 µM -2.1038045351271 0.00894200129182307 no 3303 0.0176977505234719 4688 3397440 SGTC_3138 9097216 49.47 µM -2.10959157916525 0.00878636055213908 no 3304 0.0174467751492004 4658 25237486 SGTC_2835 9006588 71.43 µM -2.11580066257527 0.00862201489556454 no 3305 0.0171808823689321 4635 2345538 SGTC_950 1165-0508 94.1 µM -2.1332596032784 0.00817426604939174 no 3306 0.0164517180530607 4689 6148369 SGTC_610 4215-0184 155 µM -2.15646330963948 0.00761087347504137 no 3307 0.0155237528804102 4721 5605015 SGTC_2654 protoveratrine a 100 µM -2.17209147173761 0.00725095755584643 no 3308 0.0149243820588889 4745 5702278 A heart drug and vasodilator. SGTC_266 formosanin C 406 nM -2.17314317900859 0.00722728480971952 no 3309 0.0148847713815357 4602 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2276 7947513 42.08 µM -2.17783218866035 0.00712256784899418 no 3310 0.0147092662586635 4655 2105100 SGTC_2775 cyproheptadine 69.59 µM -2.19788921273273 0.00668960422032708 no 3311 0.0139785009057692 4720 2913 A selective serotonin reuptake inhibitor. SGTC_2926 9010726 65.15 µM -2.20381417806123 0.00656623558398085 no 3312 0.0137687075322348 4700 2994293 SGTC_1557 sumaresinolic acid 42.3 µM -2.20588640508881 0.00652356533348117 no 3313 0.0136959771710525 4706 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1867 st057372 64 µM -2.21423599476902 0.00635410951116024 no 3314 0.0134062744860514 4720 688837 SGTC_2358 9037157 4 µM -2.21465655681686 0.00634567817067347 no 3315 0.0133918234318475 4705 2388925 SGTC_319 1348-1596 45.5 µM -2.23618887229168 0.00592702088884846 no 3316 0.0126697009107141 4760 5380505 SGTC_1844 rapamycin 4 nM -2.24070821493683 0.00584232601629989 no 3317 0.0125224908180135 4579 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_961 1252-1571 372 µM -2.24402613895889 0.00578083158047725 no 3318 0.0124153597940736 4731 6813498 SGTC_1162 k048-0130 20.1 µM -2.24977604107473 0.00567562199357799 no 3319 0.0122315828245825 4733 6797406 SGTC_1397 3532-0190 20.1 µM -2.24986964784401 0.0056739233665778 no 3320 0.0122286105938632 4738 5322280 SGTC_1790 st045711 43.5 µM -2.27982938441488 0.00515290598170945 no 3321 0.0113089047570893 4734 585119 SGTC_1335 1486-0900 202 µM -2.28719496222384 0.00503152311076918 no 3322 0.0110922229718661 4732 X1335 SGTC_1637 st007924 17.4 µM -2.29551858570057 0.00489742215052093 no 3323 0.0108517112671335 4690 683336 SGTC_539 4859-0462 2.54 µM -2.33584448065498 0.00429179645919978 no 3324 0.00974967420493664 4729 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1038 k292-0204 154 µM -2.4203710695502 0.00323468152049835 no 3325 0.00775233821572746 4717 4454212 SGTC_2679 rapamycin 1 nM -2.45134709401243 0.00291024066309591 no 3326 0.00711613201120778 4631 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_2558 carylophyllene oxide 100 µM -2.47919651648353 0.00264391480550827 no 3327 0.00658393671852163 4781 6708694 An oxygenated terpenoid and antifungal agent. SGTC_453 enantio-paf c16 10 µM -2.4883701626514 0.00256113225773647 no 3328 0.0064165042898811 4319 13871343 A lipid and platelet activating factor SGTC_771 0250-0039 27.3 µM -2.50458817744892 0.00242049405795462 no 3329 0.00612970213744952 4739 3005115 SGTC_1214 0358-0031 63.7 µM -2.520182573773 0.00229189182824119 no 3330 0.00586469889217694 4738 4301366 SGTC_2645 abamectin 100 µM -2.5545321839384 0.00203018509790079 no 3331 0.00531652996340317 4756 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_1862 st057513 3.81 µM -2.6865083956837 0.00125794284857646 no 3332 0.00361015668050767 4771 5393163 SGTC_85 0868-0259 160.055 µM -2.69420505200648 0.001222546498588 no 3333 0.00352783714221742 4767 83173 SGTC_923 1900-2434 73.3 µM -2.69539761715234 0.00121714426751256 no 3334 0.00351523399486842 4748 5910570 SGTC_2636 apigenin dimethyl ether 100 µM -2.70006845103656 0.00119619543155985 no 3335 0.0034662605451647 4753 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2290 7904846 200 µM -2.73140069953709 0.00106398907136633 no 3336 0.00315328713894345 4781 2962154 SGTC_926 2268-1401 59.4 µM -2.83908894754372 0.000705185862868142 yes 3337 0.00226212717948768 4773 2931578 SGTC_428 3448-4153 16.5 µM -2.91327854746035 0.000526979340148813 yes 3338 0.00178827707178527 4768 3834874 SGTC_1864 st057645 30.4 µM -2.92531456772361 0.000502347209475671 yes 3339 0.00172054093627748 4804 688666 SGTC_1228 0124-0032 52.5 µM -2.97243939450323 0.000415807196882978 yes 3340 0.00147721766003839 4796 X1228 SGTC_1674 st016616 23.6 µM -2.9905374383489 0.000386415650734687 yes 3341 0.00139243494591465 4780 625830 SGTC_2936 9038235 15.59 µM -3.14272230965068 0.000205437500719172 yes 3342 0.000836922764880729 4773 4749415 SGTC_1015 4130-4525 82 µM -3.25697794395607 0.000125558243832479 yes 3343 0.000563025911364869 4798 1363237 SGTC_763 3453-1109 128 µM -3.30281274413843 0.000102604824801864 yes 3344 0.000478601420085448 4799 1560353 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -3.30621301463058 0.000101069494271738 yes 3345 0.000472830832992619 4777 6708760 SGTC_2921 7974240 10.71 µM -3.32983608112281 9.09840724068814e-05 yes 3346 0.000434485622031064 4795 2979074 YDR527W RBA50 SGTC_1787 fluconazole 80 µM -3.41754506718812 6.12246237363705e-05 yes 3347 0.000315943157645154 4611 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_1014 4130-3005 69.3 µM -3.43090350382958 5.75935309279753e-05 yes 3348 0.000300787276445442 4795 743608 SGTC_1870 st057514 26.5 µM -3.47209814968494 4.76330176577906e-05 yes 3349 0.00025820374885755 4801 5393161 SGTC_2682 pyrogallin 40.03 µM -3.50825921914705 4.02524415983671e-05 yes 3350 0.000225524662117354 4809 822798 An ATP competetive kinase inhibitor. SGTC_927 2425-1185 123 µM -3.54503211154874 3.38642854254042e-05 yes 3351 0.000196282629092272 4799 730375 SGTC_1022 4477-0945 21.3 µM -3.89164986436868 6.13298447138237e-06 yes 3352 4.97824298454657e-05 4798 4648966 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -4.20640048140759 1.14633387228564e-06 yes 3353 1.29735132066141e-05 4802 115019 SGTC_1462 k081-0014 26.5 µM -4.38092080328755 4.29529937256445e-07 yes 3354 5.90894115067709e-06 4562 3270634 SGTC_1463 k081-0032 34.1 µM -4.73045541291269 5.3799796406939e-08 yes 3355 1.12008362815778e-06 4594 977755 SGTC_2238 6671620 73.2395 µM -5.7137926210879 6.99230014726942e-11 yes 3356 5.52428151033413e-09 4792 729941