SGTCid condition conc unit TAE1|YBR261C.score TAE1|YBR261C.strain.pval TAE1|YBR261C.strain.significant TAE1|YBR261C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1191 1487-1166 10.6 µM 6.01460882367675 3.39594102884486e-12 yes 1 9.01607991784715e-10 8 3955771
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 5.44183869263053 2.66924984023939e-10 yes 2 2.63667082431635e-08 37 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_938 3126-1755 342 µM 4.28129097209324 5.16086829326602e-07 yes 3 9.29061046545395e-06 8 1777771
SGTC_2126 5251174 33.877 µM 4.18185054705025 9.11991966219113e-07 yes 4 1.44573009391772e-05 23 790722
SGTC_2435 5706476 10.6 µM 4.12504068416111 1.25555505687728e-06 yes 5 1.85334614005559e-05 21 5725375
SGTC_1756 st041558 35.5 µM 4.05824376375512 1.81903895211549e-06 yes 6 2.47215719472251e-05 11 3955792
SGTC_1357 1503-1303 39.5 µM 3.87651469943419 4.8484828606777e-06 yes 7 5.29817055506127e-05 35 292895
SGTC_2432 5630864 12.22 µM 3.75486683801724 9.13271732696398e-06 yes 8 8.67168302696766e-05 26 5714970
SGTC_394 menadione 8.33 µM 3.56050775264039 2.4174403101662e-05 yes 9 0.000185069191219846 48 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1753 st043925 64 µM 3.5284434894132 2.82579629486075e-05 yes 10 0.000209005593840103 14 670181
SGTC_702 1488-0190 94 µM 3.50455623957649 3.17160751647733e-05 yes 11 0.000228684476864615 25 949357
SGTC_1333 1482-0047 286 µM 3.42925301771803 4.54285217473861e-05 yes 12 0.000302622505662754 27 3811116
SGTC_2831 7999036 19.48 µM 3.40568639596991 5.07620037623246e-05 yes 13 0.000329989717040396 73 2988270
SGTC_716 1683-5115 658 µM 3.39683331360675 5.29142169334616e-05 yes 14 0.0003408523925451 41 723597
SGTC_2430 5571206 200 µM 3.27183726973293 9.41236561403096e-05 yes 15 0.000534255291114877 88 1731771
SGTC_1198 1612-1005 86.7 µM 3.24623944268695 0.000105654736894717 yes 16 0.00058470219465194 35 6998509
SGTC_1208 2323-2347 50.3 µM 3.1959748028821 0.00013225855124002 yes 17 0.00069679640692596 30 5412760
SGTC_457 grayanotoxin iii 135 µM 3.07873901781084 0.000220630974845272 yes 18 0.00103939350482639 136 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1924 st058459 75.1 µM 2.99803964984178 0.000310735603548758 yes 19 0.0013586115981406 41 688683
SGTC_699 0375-0592 111 µM 2.97322345744549 0.000344690742662186 yes 20 0.00147344912016654 61 762578
SGTC_715 0868-0130 184 µM 2.94481445127275 0.000387781631095082 yes 21 0.00161574195626712 36 2876258
SGTC_1793 st048256 72.231 µM 2.88090893584591 0.000503617198370008 yes 22 0.00198265094241299 27 672022
SGTC_3013 9080133 71.4286 µM 2.85430500798018 0.00056068428705958 yes 23 0.00215655499738938 78 17050193
SGTC_2641 levomentholum 100 µM 2.82710743871261 0.000625157306995774 yes 24 0.00234852829775074 27 16666
SGTC_1453 4237-0541 195 µM 2.80863091586135 0.000672789909128745 yes 25 0.00248763245771202 84 739892
SGTC_2746 daunorubicin 9.88 µM 2.80404196942302 0.000685128360239923 yes 26 0.00252331676882347 20 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1503 4585-0012 61.3 µM 2.76922048784007 0.000785775824731535 yes 27 0.0028095297378027 76 2922052
SGTC_3 0833-0587 95.581 µM 2.69624720230327 0.00104224779277695 no 28 0.00350628017183634 78 5382644
SGTC_1229 0139-0193 12.2 µM 2.68143426280079 0.00110288440254239 no 29 0.00366536579198837 81 3090752
SGTC_1015 4130-4525 82 µM 2.64456186350664 0.00126812275762866 no 30 0.00408983765424611 93 1363237
SGTC_2341 7987486 176.74 µM 2.58839588574875 0.00156367362824204 no 31 0.00482120455368938 107 1258686
SGTC_2107 5363541 170.161 µM 2.55565853667317 0.00176366198555987 no 32 0.00529935340394538 85 244052
SGTC_2917 7979103 53.79 µM 2.53104433027597 0.00192905905944042 no 33 0.0056861737268727 133 2980565
SGTC_71 0417-1750 47.813 µM 2.52684047352982 0.0019586765399977 no 34 0.00575468842267668 154 6811472
SGTC_1433 4060-0023 7.6 µM 2.49576587610841 0.00219073635068943 no 35 0.00628427629275688 97 3840627
SGTC_2850 9015429 58.44 µM 2.47791489224225 0.00233505101545632 no 36 0.00660763318918686 113 6457570
SGTC_1434 4073-0095 163 µM 2.47218624720164 0.00238315605037748 no 37 0.00671447668722875 91 24133745
SGTC_996 3970-0799 1.8 µM 2.47127436270243 0.00239089561350841 no 38 0.00673162413989617 244 6615648 YGL040C HEM2
SGTC_3297 9117502 71.43 µM 2.47105556514469 0.00239275602468803 no 39 0.00673574425147801 89 7453720
SGTC_1745 st081495 74 µM 2.4694818417993 0.0024061758630379 no 40 0.00676544427708024 226 13842402 YBL026W LSM2
SGTC_2568 diosmetin 100 µM 2.45390491813304 0.00254272718705388 no 41 0.00706571705433812 133 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1451 4152-0210 104 µM 2.4252043603253 0.0028127942302147 no 42 0.0076498857557708 141 659563
SGTC_1008 4106-0037 6 µM 2.41873595636195 0.00287712545146592 no 43 0.00778727043933481 100 2905394
SGTC_1188 1403-0014 4.57 µM 2.41780592045044 0.00288648338352789 no 44 0.00780720126727315 199 9614867
SGTC_2693 st077581 40.7 µM 2.41454660999544 0.00291949526569482 no 45 0.00787740353897953 174 25238761
SGTC_2742 clothiapine 36.27 µM 2.41348769584721 0.00293029348582941 no 46 0.00790033068349574 85 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1344 1488-0097 29.1 µM 2.40904777965685 0.00297596229556758 no 47 0.00799710195310519 125 747966
SGTC_3354 9151612 71.43 µM 2.4056751796965 0.00301108030068208 no 48 0.00807130523058308 115 27261949
SGTC_3315 9136395 68.55 µM 2.39591794373981 0.00311479216494776 no 49 0.0082894006643595 117 16876844
SGTC_1679 SEC14.276 6.7 µM 2.39253665217461 0.00315147616950228 no 50 0.00836617839092469 190 1005053 YMR079W SEC14
SGTC_987 1497-1013 404 µM 2.37476674566152 0.00335073164555933 no 51 0.00878002153085316 92 1676435
SGTC_2595 hexamethylquercetagetin 100 µM 2.3642836699939 0.00347352238573798 no 52 0.00903248716476413 137 386331
SGTC_603 3794-0023 45.9 µM 2.35008904758005 0.00364622647027345 no 53 0.00938446014832997 110 3802260
SGTC_1354 1498-1681 81 µM 2.34214398663875 0.0037462207633121 no 54 0.00958665820732248 145 5754243
SGTC_705 1124-0212 310 µM 2.33708403949961 0.00381117876317321 no 55 0.00971740736879916 133 9554485
SGTC_2602 kawain 100 µM 2.33167075565794 0.00388178902095819 no 56 0.00985900920725579 164 5369129
SGTC_2309 7664088 163.95 µM 2.30411612922309 0.00425969682678224 no 57 0.0106080627842619 197 704922
SGTC_2103 5378138 10 µM 2.30028688774461 0.00431473903593002 no 58 0.0107159860223901 144 244142
SGTC_2585 alliin 100 µM 2.29120152509704 0.00444788528843691 no 59 0.0109758804031608 176 87310 A garlic compound which reacts with lipids.
SGTC_57 miconazole 162.5 nM 2.2747788887236 0.00469789990084477 no 60 0.0114595986416767 150 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1420 4'-methoxyflavone 42 µM 2.24724099029972 0.00514536193378863 no 61 0.0123123149213504 129 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_739 1486-1183 203 µM 2.24670449545688 0.00515444392507042 no 62 0.0123294593834388 144 4346692
SGTC_398 bronopol 33.3 µM 2.23861524842823 0.00529312167475034 no 63 0.012590480610562 166 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_115 0527-0192 112.043 µM 2.22672342517691 0.00550301481016956 no 64 0.0129828819274573 279 4233931
SGTC_1376 2910-0861 41.3 µM 2.21547365497649 0.00570834924669428 no 65 0.013363785337502 183 1112859
SGTC_2104 5389443 200 µM 2.2127007435584 0.00575999458720841 no 66 0.013459142052534 185 2244536
SGTC_2829 7992743 58.44 µM 2.21060019997142 0.00579939271468869 no 67 0.0135317674522318 211 16462845
SGTC_1652 st011932 78 µM 2.20562588570453 0.00589364680125718 no 68 0.0137051025430135 145 1551076
SGTC_2316 5844804 197.44 µM 2.19384427642356 0.00612232622203083 no 69 0.0141233032654667 238 776813
SGTC_1129 3453-1384 223 µM 2.18752155931438 0.00624826248233395 no 70 0.0143522355567725 211 1084452
SGTC_2143 5623677 140.463 µM 2.18695607391606 0.00625963683627757 no 71 0.0143728654091461 111 5375313
SGTC_1200 1643-0193 18.4 µM 2.18632887080526 0.00627227404176723 no 72 0.0143957766877933 177 5403974
SGTC_2349 9023730 187.07 µM 2.17595408429092 0.00648461251149577 no 73 0.0147793470252623 192 4126287
SGTC_2644 guaiazulene 100 µM 2.17117123910765 0.00658462564329624 no 74 0.0149591152839261 122 3515 A coloring agent.
SGTC_1751 st044839 27.194 µM 2.1680127757158 0.00665141711126929 no 75 0.0150788572551995 124 5291326
SGTC_1350 1495-0454 146 µM 2.15403147919529 0.0069543234441806 no 76 0.0156188516680676 216 1069057
SGTC_2690 usnic acid 100 µM 2.14240338758695 0.00721545754678298 no 77 0.0160805177675378 216 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1907 st060210 83.7 µM 2.14125347659405 0.00724174530311533 no 78 0.0161268013343243 208 688793
SGTC_3176 9106582 49.47 µM 2.1387834615833 0.00729849725045596 no 79 0.0162266047451743 60 17018027
SGTC_1424 4048-1941 275 µM 2.10804174810381 0.00803833312987866 no 80 0.0175136892127638 208 X1424
SGTC_1120 ficusin 1.78878 µM 2.10670275472804 0.00807200492251785 no 81 0.0175716766402382 186 6199 A DNA cross-linker.
SGTC_1572 epiandrosterone 68.9 µM 2.10258734739335 0.00817627276450118 no 82 0.0177509284521083 192 441302 A steroid.
SGTC_1906 st060206 94.7 µM 2.10165317122752 0.00820010516412493 no 83 0.0177918342509359 196 5133468
SGTC_1379 2144-0755 36.5 µM 2.09644586275013 0.00833407376416034 no 84 0.0180213287986235 220 5392327
SGTC_465 cgp-37157 41 µM 2.07880007583995 0.00880244375822865 no 85 0.0188178649651655 116 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_1508 1080-0625 72.9 µM 2.05616644361735 0.00943687637208391 no 86 0.0198832377757053 177 767111
SGTC_1903 st060211 78.3 µM 2.05370146510845 0.00950832903024853 no 87 0.0200022973357227 238 688960
SGTC_988 1497-1057 103 µM 2.04658235272512 0.00971735408009005 no 88 0.0203495545090205 200 3533044
SGTC_3034 9090421 49.47 µM 2.03223260339353 0.0101509110738942 no 89 0.0210650568662897 161 17173761
SGTC_1202 1988-0068 29.6 µM 2.01595828158908 0.010662951964983 no 90 0.0219021691886166 235 2850480
SGTC_2918 7977171 22.06 µM 2.0118806539316 0.0107947179617619 no 91 0.0221162596011673 211 2236483
SGTC_2284 7945075 39.21 µM 1.97621153920274 0.0120090445034893 no 92 0.024065411761123 254 1245402
SGTC_646 4092-0839 27.3 µM 1.97619881721906 0.0120094979258787 no 93 0.0240661319077127 215 877796
SGTC_1211 1056-0033 32.3 µM 1.97608556960079 0.012013534822248 no 94 0.0240725432536116 196 6741922
SGTC_2514 salinomycin 42.74 µM 1.97178631018278 0.012167661697766 no 95 0.0243170028899061 299 23682228 A polyether potassium ionophore.
SGTC_110 0850-0284 111.64 µM 1.94730923872054 0.0130782107074143 no 96 0.0257488358821115 138 3906265
SGTC_1125 tnp00248 1.32998 µM 1.93751965404588 0.0134585453958551 no 97 0.0263409266279884 334 24207736
SGTC_2023 5144124 124 µM 1.93396456402672 0.0135990084809954 no 98 0.0265587424430991 233 2830192
SGTC_2989 9073649 71.4286 µM 1.91834552684333 0.0142312120596376 no 99 0.027533606629677 335 21367202
SGTC_2437 5741531 144.16 µM 1.9145007938586 0.0143906616616596 no 100 0.027778098897238 260 2262990
SGTC_382 3229-0966 23.2 µM 1.91027705647571 0.0145676002678173 no 101 0.0280487751296489 246 5722370
SGTC_811 0416-0114 265 µM 1.90793554940175 0.0146664937418153 no 102 0.0281997734453924 251 6612453
SGTC_2102 5377816 72.7585 µM 1.9035422397561 0.014853604197031 no 103 0.0284849137465342 254 1379702
SGTC_3343 9148379 18.9835 µM 1.89367982401979 0.0152811325951936 no 104 0.0291337604724624 224 1955036
SGTC_910 3454-3003 490 µM 1.88837334944067 0.0155155069370993 no 105 0.0294879232694586 286 820824
SGTC_2919 7978188 46.38 µM 1.88525992280099 0.0156544506378924 no 106 0.0296973770723201 250 2980291
SGTC_560 2332-1943 155 µM 1.88067091739111 0.0158611911423754 no 107 0.0300083490819828 215 21177716
SGTC_2852 9023854 51.95 µM 1.87290223855223 0.0162165173911437 no 108 0.0305409430113938 257 19798528
SGTC_912 3474-0017 2.18 µM 1.86547441655878 0.0165626086258882 no 109 0.0310574674771497 269 3360550
SGTC_2247 cerulenin 830 nM 1.86407966404646 0.0166282957280513 no 110 0.0311552589350382 258 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2038 4100038 30.985 µM 1.85956473293698 0.0168424613487554 no 111 0.0314735664105731 291 3596803
SGTC_1563 conessine 56.1 µM 1.85833953822153 0.016900983766197 no 112 0.0315604062209079 311 441082 An anti-amoebic, histamine inhibitor.
SGTC_983 1491-0821 12.2 µM 1.85780135755839 0.0169267453150997 no 113 0.0315986141442189 220 46495113
SGTC_2794 7785382 27.27 µM 1.85588889933747 0.0170185623903487 no 114 0.0317346977771166 349 2205081
SGTC_505 gw-5074 63.9 µM 1.8547394279074 0.0170739530771981 no 115 0.0318167227516231 283 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_2065 5221596 34.26 µM 1.85170330079524 0.0172209993842036 no 116 0.0320342198903408 254 788581
SGTC_2221 6807166 181.081 µM 1.85040535554315 0.0172841910987883 no 117 0.0321275738505113 154 674925
SGTC_3336 9143619 71.43 µM 1.84787350030595 0.0174080270895794 no 118 0.0323103224453024 279 45595730
SGTC_697 0508-1955 564 µM 1.84254095382496 0.0176713282872835 no 119 0.0326980308906009 292 6243113
SGTC_333 3486-0131 40.1 µM 1.84041949655233 0.0177770189136746 no 120 0.0328533366367161 256 6744690
SGTC_376 3970-0862 59.1 µM 1.83579491204832 0.0180092852948215 no 121 0.0331939971257989 270 3135186
SGTC_1138 3761-0006 1.03 µM 1.82955635026283 0.0183267082295672 no 122 0.0336581529198737 221 12061087
SGTC_1210 3013-0140 750 nM 1.81570010292074 0.0190488097252059 no 123 0.0347081941374666 254 905973
SGTC_2584 androsterone 48.74 µM 1.80704221227893 0.0195121767046027 no 124 0.0353778488686308 454 2754130 A steroid.
SGTC_2442 5158906 48.48 µM 1.78933281590817 0.0204898492838718 no 125 0.0367806160606298 294 1893835
SGTC_1309 pyrazolanthrone 13.4 µM 1.78759141571574 0.0205881892724412 no 126 0.0369209757238969 305 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1507 4075-3230 155 µM 1.78281414417761 0.0208600254601414 no 127 0.0373082812746165 224 659771
SGTC_1222 0366-0074 1.18 µM 1.78072396776976 0.020979912708243 no 128 0.0374787778354271 287 286520
SGTC_1195 1502-0147 41.1 µM 1.76874157676593 0.0216785011600162 no 129 0.0384685052388283 330 817940
SGTC_558 k064-0027 21.3 µM 1.76725897349282 0.0217662898280089 no 130 0.0385924336370298 304 5088526
SGTC_3293 9120939 62.045 µM 1.76263187118463 0.0220422055825711 no 131 0.0389812990421395 274 934087
SGTC_2308 7584454 197.62 µM 1.76212528903251 0.0220725917938627 no 132 0.0390240657037932 339 893577
SGTC_478 N-arachidonylglycine 10 µM 1.75215016398088 0.0226781683384096 no 133 0.0398739952037262 163 5283389
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.74681914164331 0.0230075098117813 no 134 0.0403343575730257 284 4213774
SGTC_1450 4112-4260 37.6 µM 1.74603408143586 0.0230563481234804 no 135 0.0404025149212716 315 1633175
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.74204349972313 0.0233059525599055 no 136 0.0407504164449886 377 551469
SGTC_130 0136-0219 337.655 µM 1.74193979932644 0.0233124690516317 no 137 0.0407594894176295 310 234244
SGTC_1289 0976-0073 69.1 µM 1.73415010564777 0.0238063732440817 no 138 0.041445726564581 306 3391136
SGTC_936 3005-4620 401 µM 1.73353603665842 0.0238456794872298 no 139 0.0415002190539792 337 777207
SGTC_693 4161-2696 114 µM 1.73314161671788 0.0238709548683028 no 140 0.0415352504930111 240 805759
SGTC_1301 naphtanilide LB 4.81 µM 1.73018168873776 0.0240613537052528 no 141 0.0417989094326487 306 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1175 0741-0056 27.6 µM 1.71517063540149 0.0250466981840415 no 142 0.0431569734639055 345 765927
SGTC_701 4424-0219 185 µM 1.71141853050203 0.0252982080832343 no 143 0.0435019394103174 326 2911779
SGTC_795 0685-0265 78 µM 1.70561585707889 0.0256913354982468 no 144 0.044039812523763 343 302754
SGTC_502 l-744,832 89.3 µM 1.69337320422649 0.0265375602289251 no 145 0.0451922260011547 325 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2716 st080858 38.6235 µM 1.6926722618373 0.0265867067718423 no 146 0.0452589339565852 290 5296050
SGTC_2873 9040596 71.43 µM 1.69095893600124 0.0267071566857984 no 147 0.0454223228777376 360 6463863
SGTC_1618 st003135 44.5 µM 1.68806232856993 0.0269118299116692 no 148 0.0456996324597475 283 1270615
SGTC_2583 asiatic acid 100 µM 1.68791695119059 0.0269221366382862 no 149 0.0457135860931578 314 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1064 honokiol 6.76 µM 1.68263620459966 0.0272987620963724 no 150 0.0462227692555866 337 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_3018 9082602 49.47 µM 1.67245190091491 0.0280375258233001 no 151 0.0472176225087432 348 17332089
SGTC_1586 deoxycorticosterone acetate 53.7 µM 1.67172582455977 0.0280908247738237 no 152 0.0472891996742396 290 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_3107 9121808 49.47 µM 1.66954529295251 0.0282513980024138 no 153 0.0475046809932651 230 662681
SGTC_2275 7947463 200 µM 1.66586655299213 0.02852402997548 no 154 0.0478699983765154 310 1225414
SGTC_620 0109-0052 432 µM 1.66205786343923 0.0288085949165304 no 155 0.0482505865497134 328 493037
SGTC_1944 st076371 56.9 µM 1.66203170338395 0.028810557587483 no 156 0.04825320897265 346 24208455
SGTC_1938 st074717 56.4 µM 1.66011084343664 0.0289549750955022 no 157 0.048446077953667 284 17250979
SGTC_1913 st060213 96.1 µM 1.65975564050958 0.0289817463988341 no 158 0.0484818104860052 386 688959
SGTC_984 1492-0255 2.91 µM 1.65809240067975 0.0291073770044309 no 159 0.0486494087616794 317 1585198
SGTC_1220 1838-0075 193 µM 1.65460256457056 0.0293724480998961 no 160 0.0490025714816862 356 5529645
SGTC_186 3455-3465 67.277 µM 1.65011216772073 0.0297164627557474 no 161 0.0494599982715986 212 755278
SGTC_886 0866-0150 153 µM 1.64625091595948 0.0300149450658393 no 162 0.0498560552303161 376 271463
SGTC_188 3229-0966 278.469 µM 1.64215975354376 0.0303339081083084 no 163 0.0502784504778471 426 5722370
SGTC_1336 1486-0901 104 µM 1.63813656277263 0.0306503059403077 no 164 0.0506966046540913 342 5006114
SGTC_2272 7805186 180 µM 1.63708138070167 0.0307337400534947 no 165 0.0508067332330505 315 2956062 YPR165W RHO1
SGTC_302 1094-0063 18.9 µM 1.63129060323312 0.0311949758006779 no 166 0.0514145076036595 293 5440289
SGTC_1323 1348-1351 11.2 µM 1.62968289536638 0.0313240405331468 no 167 0.051584267129867 314 6989654
SGTC_111 0083-0039 52.457 µM 1.62951572205762 0.0313374863014284 no 168 0.0516019446815213 193 759313
SGTC_2281 7943571 200 µM 1.6282335877952 0.0314407672501609 no 169 0.0517376826900816 356 1244024
SGTC_2932 9016711 44.54 µM 1.62412266489397 0.0317738175193429 no 170 0.0521748158261548 395 7117328
SGTC_1881 5652484 16 µM 1.6220998362833 0.0319387657574458 no 171 0.0523909866168189 378 2255129
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.61846917106008 0.0322365959876871 no 172 0.052780762763171 335 756377
SGTC_600 1495-0418 41.6 µM 1.60526954155279 0.0333387627499453 no 173 0.0542172495755698 341 5377768
SGTC_2898 9056270 58.44 µM 1.60511428034725 0.0333519094101249 no 174 0.0542343285788122 288 19154699
SGTC_1316 1272-0050 65.9 µM 1.59874570809073 0.0338948547507983 no 175 0.0549385584667697 345 7340392
SGTC_549 1661-1316 519 µM 1.59498766349164 0.0342186393368461 no 176 0.0553574972555696 369 2857282
SGTC_1143 3454-2408 5.08 µM 1.59367151853454 0.0343326348092103 no 177 0.0555048133250814 287 X1143
SGTC_435 c-PAF 6.7 µM 1.59333884056332 0.034361498460873 no 178 0.0555420989202655 395 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2790 5423970 71.43 µM 1.59297634862147 0.0343929715172252 no 179 0.0555827484862593 435 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1875 nocodazole 6 µM 1.58602772185218 0.0350008731788174 no 180 0.0563665105700294 354 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3344 9148862 3.898 µM 1.58426489576996 0.0351564887573133 no 181 0.0565667253682336 354 4905352
SGTC_2605 digitonin 300 nM 1.58234931391182 0.0353262321375471 no 182 0.0567849244141563 442 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_442 cape 100 µM 1.57854332689181 0.0356654825326624 no 183 0.057220421333501 334 5281787
SGTC_2657 nystatin 74.44 µM 1.57368423728021 0.0361024782613248 no 184 0.0577802338728066 379 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2239 6685329 187.64 µM 1.57261732579909 0.0361990142391117 no 185 0.0579037267072081 401 805680
SGTC_3230 9131665 49.47 µM 1.57049870144598 0.0363913375299582 no 186 0.0581495681320454 209 15943720
SGTC_512 prima-1 270 µM 1.56654678415723 0.0367523170581963 no 187 0.0586103324859376 387 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1 0258-0098 57.368 µM 1.56646684514875 0.03675964902589 no 188 0.0586196822734487 318 6790032 YDR047W HEM12
SGTC_1252 0493-0875 34.8 µM 1.56539449706861 0.0368581199848697 no 189 0.0587452189668522 385 3960963
SGTC_2164 5685496 200 µM 1.56379994625389 0.0370049421854349 no 190 0.0589322784656946 378 759046
SGTC_2781 5567276 71.43 µM 1.56319466146645 0.0370608003092817 no 191 0.0590034077160465 398 2853274
SGTC_1257 0669-0121 16 µM 1.56046833852462 0.0373132512767665 no 192 0.0593246231937056 455 4307855
SGTC_2002 4023503 131 µM 1.55732183916175 0.0376063540153131 no 193 0.0596970464183461 494 4736863 YCR052W RSC6
SGTC_1946 st076057 65.1 µM 1.54761130202569 0.0385227813820716 no 194 0.0608579543275683 255 953009
SGTC_2121 5257820 149.641 µM 1.54145477914742 0.0391131703762354 no 195 0.0616030703399877 420 791256
SGTC_538 2922-0838 53.3 µM 1.53908238837062 0.0393426313971913 no 196 0.0618920919978004 473 777039
SGTC_1499 4480-0877 67.3 µM 1.53538158224165 0.039702764606243 no 197 0.0623450625439946 334 2861909
SGTC_2220 6782180 200 µM 1.53361259282831 0.039875853089546 no 198 0.0625624942263776 303 833803
SGTC_986 1493-0483 84 µM 1.53315289258941 0.0399209331695508 no 199 0.0626190939885533 365 40079
SGTC_1644 st010134 20.9 µM 1.53178016578513 0.0400557949257002 no 200 0.0627883460598632 359 3818134
SGTC_2798 7813637 45.45 µM 1.53169330977377 0.0400643404187206 no 201 0.0627990670600904 433 956368
SGTC_2692 st077426 47.7 µM 1.52762187774141 0.040466581049753 no 202 0.0633032233315336 415 25238571
SGTC_3125 9127534 49.47 µM 1.52487227630506 0.0407400805579077 no 203 0.0636454790126821 289 1639235
SGTC_3160 9100216 49.47 µM 1.52188722161458 0.0410386964842234 no 204 0.0640186707672239 394 17191039
SGTC_1799 st045822 46.1415 µM 1.52115560630265 0.0411121552914982 no 205 0.0641103964702975 384 3674992
SGTC_314 1671-0008 2.74 µM 1.51470520337689 0.0417644407876759 no 206 0.0649235380568999 477 3913060
SGTC_2192 5915882 198.485 µM 1.50986281475889 0.0422596060460089 no 207 0.0655392163996408 355 2876149
SGTC_211 3455-0679 143.504 µM 1.50473946644584 0.0427886615831311 no 208 0.0661955360652419 447 748649
SGTC_1779 st039427 55 µM 1.50471396485805 0.04279130829802 no 209 0.0661988155979299 501 1124498
SGTC_3257 9139206 32.98 µM 1.50239208220093 0.0430328429034571 no 210 0.0664979399943521 319 4910041
SGTC_362 0310-0100 9.03 µM 1.50135060022043 0.0431415406525317 no 211 0.0666324519009254 447 790235
SGTC_46 0329-0187a 2.197 µM 1.50114449281544 0.0431630780056944 no 212 0.0666590965084925 533 46494817
SGTC_1553 gossypol 38.6 µM 1.49865999251533 0.0434233816944756 no 213 0.0669809303046458 277 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2839 9003951 25.97 µM 1.49495891404166 0.0438134961260484 no 214 0.0674625825835252 380 2990634
SGTC_597 k018-0003 82.8 µM 1.49479704505712 0.0438306223468694 no 215 0.0674837088823023 443 6786234
SGTC_1760 st045453 10.4495 µM 1.49286274799335 0.0440356948579541 no 216 0.0677365590381358 507 3323419 YIL048W NEO1
SGTC_31 0508-1974 57.237 µM 1.49267526425901 0.0440556127839833 no 217 0.0677611056517698 425 6810525
SGTC_2226 7298446 200 µM 1.48942898519684 0.0444016447259881 no 218 0.068187220326717 359 3283010
SGTC_1283 0922-0125 16.4 µM 1.47985663173881 0.0454347593852462 no 219 0.06945575575051 481 3360884
SGTC_56 0957-0365 83.25 µM 1.47830923312627 0.0456035662176245 no 220 0.0696625137263249 444 6752360
SGTC_2623 humulene 100 µM 1.4762711451687 0.0458266717357691 no 221 0.0699355585283163 375 6187145 An anti-inflammatory.
SGTC_3155 9099265 49.47 µM 1.47613615015956 0.0458414802964403 no 222 0.0699536729911622 385 25236499
SGTC_1921 5740136 50 µM 1.47114473502516 0.0463917290993892 no 223 0.0706259895831587 485 1774243
SGTC_876 0720-0963 56.8 µM 1.467352922343 0.0468132686852148 no 224 0.0711400370271277 470 765861
SGTC_3004 9076122 71.4286 µM 1.467246507548 0.0468251431013512 no 225 0.0711545047745841 441 44782551
SGTC_1678 st019265 80.2 µM 1.46332713417778 0.0472641765973734 no 226 0.0716889432049573 474 5367020
SGTC_1561 5-methoxyflavone 52.9 µM 1.46100794578016 0.047525513173261 no 227 0.0720066304330071 351 94525
SGTC_193 1273-0060 1.558 µM 1.45912952623415 0.0477380293276096 no 228 0.0722647304858614 347 2847393 YHR072W ERG7
SGTC_2608 thymoquinone 42.66 µM 1.45727032862051 0.0479491194493096 no 229 0.0725208869377396 391 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_1878 temozolomide 1 mM 1.45668419504143 0.0480158227423432 no 230 0.0726017872615268 406 5394 DNA alkylating agent.
SGTC_3215 9129942 49.47 µM 1.45473283944068 0.0482384266553438 no 231 0.0728716187346952 388 17682944
SGTC_1630 st005209 31.3 µM 1.44826093710329 0.0489826343176821 no 232 0.0737720439910208 493 3367314
SGTC_366 0181-0206 4.31 µM 1.44693921305246 0.0491357422493946 no 233 0.0739569746281517 477 274874
SGTC_999 SEC7.066 22.7 µM 1.44345695938944 0.0495409555446707 no 234 0.0744458943119061 495 740511 YDR170C SEC7
SGTC_2125 5246583 200 µM 1.44331073720274 0.049558028897313 no 235 0.0744664782340506 527 835267
SGTC_491 tetrandrine 80.3 µM 1.44091296301848 0.0498386708033514 no 236 0.0748046366913188 378 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_818 4072-2707 53.5 µM 1.43913625349669 0.0500474381800859 no 237 0.0750559610878411 410 882871
SGTC_2091 4-phenylthiadiazole 200 µM 1.43810614950286 0.0501687966895553 no 238 0.0752019690381499 462 270010
SGTC_917 harmaline 728.087 nM 1.43045328286434 0.051077756302515 no 239 0.0762934824626237 469 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_219 mitoxanthrone 164.414 µM 1.42882914681676 0.0512723367935568 no 240 0.0765266729985843 467 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_1654 st012436 41.8 µM 1.42677918077253 0.0515187754637206 no 241 0.0768217769853655 405 4323132
SGTC_224 benfluorex 43.875 µM 1.41560110283519 0.0528791721473491 no 242 0.0784461641246399 336 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_3168 9103419 49.47 µM 1.41438019757511 0.0530294692631635 no 243 0.0786251505806064 334 16649256
SGTC_1270 0831-1170 17.3 µM 1.41273902189165 0.0532320364551066 no 244 0.0788662367304431 514 6764716
SGTC_2685 mycophenolic acid 18.85 µM 1.40405750363174 0.0543138031761595 no 245 0.0801508634049133 417 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_882 0843-0131 351 µM 1.39736323622526 0.055159764440028 no 246 0.0811521843185508 503 5425421
SGTC_1711 st032263 62.8 µM 1.39510275433681 0.0554477630664391 no 247 0.0814924278652175 456 3958979
SGTC_2978 9011784 42.97 µM 1.3887660445591 0.0562614282764458 no 248 0.0824519518375261 567 2994934
SGTC_1636 st007707 68.9 µM 1.38183597531602 0.057162029548534 no 249 0.0835110350783549 548 403051
SGTC_1720 st037298 9.481 µM 1.37915478500855 0.0575134945749459 no 250 0.0839235177143199 465 597396
SGTC_358 0075-0058 9.45 µM 1.37403600330964 0.0581892107720399 no 251 0.0847152527180679 606 1069125
SGTC_937 3122-0005 46.7 µM 1.36601578854157 0.0592604606926158 no 252 0.0859670039295185 527 759535
SGTC_2899 9053889 58.44 µM 1.36327590576606 0.0596299467457125 no 253 0.0863977862941969 463 6470052
SGTC_1619 st003326 88.7 µM 1.35915220222585 0.0601894477629936 no 254 0.0870491819193805 460 2849032
SGTC_1973 st070275 50.2 µM 1.358590543109 0.0602659702140458 no 255 0.0871381867714972 453 17118334
SGTC_2211 7117706 200 µM 1.35596446205688 0.0606247677405881 no 256 0.0875552377725131 473 822771
SGTC_2676 harmalol 100 µM 1.35312727011843 0.0610142845890593 no 257 0.0880074875277534 524 5459187 A monoamine oxidase inhibitor
SGTC_3219 9131112 49.47 µM 1.35300723574079 0.0610308070905344 no 258 0.0880266593987753 489 17612988 YMR079W SEC14
SGTC_190 3970-0790 3.722 µM 1.35064486131754 0.0613566956420081 no 259 0.0884046114467033 463 2832352
SGTC_368 fentichlor 4.58 µM 1.35029174647312 0.0614055242574781 no 260 0.0884612093813091 434 7329 A pesticide.
SGTC_991 3996-0057 64.7 µM 1.34778022972326 0.0617536922553823 no 261 0.0888645392525248 509 715343
SGTC_692 k241-0027 77.8 µM 1.34590412162562 0.0620147785830946 no 262 0.0891667197197024 493 3600480
SGTC_695 3505-6186 243 µM 1.34112081083541 0.0626843400121584 no 263 0.0899406157837949 536 1819379
SGTC_1725 st036284 20.55 µM 1.33992043253181 0.0628532485718821 no 264 0.0901356072481677 573 707914
SGTC_1090 efavirenz 20.7 µM 1.33896821050796 0.0629874904335686 no 265 0.0902905110324338 509 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_1272 0839-0021 27 µM 1.33745599146791 0.0632011381092377 no 266 0.090536919141807 540 5027250
SGTC_477 mead ethanolamide 10 µM 1.33364455294186 0.0637421250436435 no 267 0.0911601871644122 336 16061185
SGTC_687 k029-0044 34.9 µM 1.33253123306982 0.0639008250465424 no 268 0.0913428426064938 543 5829338
SGTC_44 0929-0055 61.211 µM 1.32750044692106 0.0646217809719918 no 269 0.0921715960969727 486 1379590
SGTC_2934 9036370 36.88 µM 1.32290695144268 0.0652855726451414 no 270 0.0929331616592007 551 6462800
SGTC_2373 9071805 200 µM 1.32164316924549 0.065469122603137 no 271 0.0931435005712015 531 10149009
SGTC_1591 genipin 88.4 µM 1.3195400947855 0.0657754570438065 no 272 0.0934943075156229 485 442424 A DNA cross-linking agent.
SGTC_2344 7990960 76.95 µM 1.31946764093679 0.065786030456708 no 273 0.0935064106689956 492 140813
SGTC_3157 9099274 49.47 µM 1.31744726233683 0.0660814014063313 no 274 0.0938443737849182 502 17217662
SGTC_609 0986-0026 86.3 µM 1.31430649643251 0.0665426069840546 no 275 0.0943715409788955 555 2848610
SGTC_3084 9116877 49.47 µM 1.31405355394391 0.0665798584543849 no 276 0.0944140913699103 440 27241325
SGTC_720 r052-1644 49.9 µM 1.31329493562395 0.0666916788701554 no 277 0.0945417921985731 469 1422863 YOR257W CDC31
SGTC_336 4111-0029 111 µM 1.31287218867499 0.0667540548428902 no 278 0.0946130098728772 471 3131175
SGTC_2481 5478948 45.16 µM 1.29941739556241 0.0687629732258463 no 279 0.0969003625004325 540 77792
SGTC_874 0599-0792 117 µM 1.29717052244938 0.06910294681246 no 280 0.0972862603940248 628 765305
SGTC_2648 atorvastatin 78.68 µM 1.29653039330574 0.0692000412256818 no 281 0.0973964079479594 521 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_571 k831-0106 44.2 µM 1.29625583590871 0.0692417181267946 no 282 0.0974436792907326 518 4783639
SGTC_2625 euphol 100 µM 1.29502357465575 0.0694290094959599 no 283 0.0976560485533673 598 6708538 A triterpene alcohol.
SGTC_1277 0873-0036 22 µM 1.29413940029224 0.0695636353835655 no 284 0.0978086371153708 600 5965735
SGTC_3288 9119690 36.221 µM 1.293936875227 0.0695945004680215 no 285 0.097843612963675 477 17595618 YKL019W RAM2
SGTC_2301 7769476 200 µM 1.29392782147195 0.0695958805182968 no 286 0.097845176750919 487 977820
SGTC_2004 4023728 41.89 µM 1.29318774492327 0.0697087605456787 no 287 0.0979730665870264 568 360084 YDR527W RBA50
SGTC_1716 st033144 30.6155 µM 1.29011578177103 0.0701788182695697 no 288 0.0985052305751542 581 674617
SGTC_137 0438-0332 85.389 µM 1.2894208277386 0.0702854943331384 no 289 0.0986259122198984 689 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_1370 2001-0092 44.6 µM 1.28932750490306 0.0702998289635245 no 290 0.0986421263554779 637 790957
SGTC_133 0724-0033 378.92 µM 1.28695377478169 0.0706651964188102 no 291 0.0990552001909283 523 280309
SGTC_1984 st072354 53.1 µM 1.28659367741501 0.0707207502993827 no 292 0.0991179742940107 545 5762938
SGTC_1464 k208-0027 110 µM 1.27610117709807 0.0723542543305215 no 293 0.100959877784929 588 X1464
SGTC_3021 9087658 49.47 µM 1.27588357253451 0.0723884351108351 no 294 0.100998339475075 513 25237042
SGTC_70 0141-0289 43.283 µM 1.27226845981707 0.0729580996548305 no 295 0.101638875441406 791 352408
SGTC_829 1635-0120 117 µM 1.26470007312313 0.0741618197004496 no 296 0.10298943187374 603 285054
SGTC_2814 7977482 42.97 µM 1.26221977540564 0.0745595832682342 no 297 0.103434857375421 651 6456762
SGTC_1315 1237-0019 3.69 µM 1.26052811470871 0.0748318063487003 no 298 0.103739456147432 591 825140
SGTC_2678 equilin 100 µM 1.26031217560444 0.0748666099069901 no 299 0.103778384717887 594 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_2643 anethole 100 µM 1.25871007048944 0.0751252118155164 no 300 0.104067536322874 598 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2 0422-0095 29 µM 1.25533017561954 0.0756730070990872 no 301 0.104679462611872 463 6790840
SGTC_1216 1165-0504 9.65 µM 1.25521835859767 0.0756911816667519 no 302 0.104699751402065 598 6304004
SGTC_72 0744-0168 198.391 µM 1.25509978027973 0.075710458837832 no 303 0.104721270116073 573 677577
SGTC_2722 naftopidil 47.16 µM 1.25500908447342 0.0757252056979511 no 304 0.104737731080274 602 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_831 k061-1017 217 µM 1.25389823558879 0.0759060038815917 no 305 0.104939498221584 755 1240153
SGTC_2130 NSC 7 2.4545 µM 1.25290522151512 0.0760679017437099 no 306 0.105120100702959 616 21448
SGTC_1031 k035-0009 16 µM 1.2521126668085 0.076197305873981 no 307 0.105264406362819 641 5180959
SGTC_1805 st050013 60.3 µM 1.25087918301526 0.0763990357746391 no 308 0.105489279919674 543 4037144
SGTC_2076 5212012 200 µM 1.25008881271812 0.0765285101961149 no 309 0.105633553005533 472 604802
SGTC_1587 estradiol valerate 56.1 µM 1.24942968765478 0.0766366122738463 no 310 0.105753977828109 600 13791 A steroid.
SGTC_3042 9091578 49.47 µM 1.24894716488192 0.0767158236843794 no 311 0.105842199595412 531 25236497
SGTC_1831 st055328 12 µM 1.24878191193577 0.0767429660770723 no 312 0.105872425745806 603 1103068
SGTC_1127 asiatic acid 681.4 nM 1.24834795084023 0.0768142778923224 no 313 0.105951830573271 573 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1706 st031321 9.9705 µM 1.24490899997611 0.0773811753059995 no 314 0.106582601134131 584 6103185
SGTC_1332 1480-0653 17.5 µM 1.24414030403954 0.0775083252405646 no 315 0.106723964857292 582 5749438
SGTC_2828 7998861 71.43 µM 1.2431325554856 0.07767525710717 no 316 0.106909495428395 485 2988188
SGTC_163 TUB2.036 7.546 µM 1.24279007463972 0.0777320505844985 no 317 0.106972600477622 767 15992207 YJR013W GPI14
SGTC_1246 0422-0085 105 µM 1.24258935135 0.0777653511041836 no 318 0.107009597961161 643 264295
SGTC_3040 9091894 49.47 µM 1.24191645463448 0.0778770654315139 no 319 0.107133694175727 513 25236966
SGTC_3064 1327-0027 10 µM 1.24127201111643 0.0779841700919908 no 320 0.10725264028631 411 16000455 YPR107C YTH1
SGTC_965 1291-5240 308 µM 1.24111398075527 0.0780104513397761 no 321 0.107281822768802 606 2834598
SGTC_1529 apigenin 74 µM 1.23881508323601 0.0783935299110792 no 322 0.107706993374012 622 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_350 k064-0020 19.8 µM 1.23765432965484 0.078587494071378 no 323 0.107922130068566 635 2790705
SGTC_3039 9090270 49.47 µM 1.23528627347886 0.0789843285301355 no 324 0.108361990249463 549 17173750
SGTC_713 1488-1073 324 µM 1.23480934697446 0.0790644342936033 no 325 0.108450733939281 584 3312542
SGTC_2566 crystal violet carbinol 226 nM 1.23238042635778 0.0794733567140499 no 326 0.108903504572959 523 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1525 8-methoxypsoralen 92.5 µM 1.23129412080746 0.0796567595085834 no 327 0.109106439987359 662 4114 Related to psoralen; DNA damaging agent.
SGTC_80 0159-0065 512.242 µM 1.22799239761812 0.080216160669772 no 328 0.109724910933896 466 1548079
SGTC_2117 5521686 200 µM 1.22790467562246 0.0802310635351576 no 329 0.109741377060477 592 803312
SGTC_1263 0774-1208 64.8 µM 1.22704283588864 0.0803775905709114 no 330 0.10990324566156 683 906585
SGTC_200 k038-0079 37.545 µM 1.22180002657819 0.0812733144546668 no 331 0.110891629259578 575 3436683
SGTC_865 0488-0499 301 µM 1.22135670943745 0.081349398270104 no 332 0.110975495237477 651 9634651
SGTC_3025 9087895 49.47 µM 1.22090625188817 0.0814267625699502 no 333 0.111060758550358 655 17173641
SGTC_758 0868-0029 16 µM 1.21868161079601 0.0818096497922621 no 334 0.111482530103684 604 762687
SGTC_738 1315-0003 72.4 µM 1.2141655144814 0.0825910949141367 no 335 0.112342263197473 643 6251474
SGTC_2408 sulbentine 18.36 µM 1.21213012319487 0.0829451211753547 no 336 0.11273128721788 606 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1296 1068-0102 11.9 µM 1.20944290924461 0.0834142692316037 no 337 0.113246365989072 612 767053
SGTC_1022 4477-0945 21.3 µM 1.20727194939563 0.0837947412083785 no 338 0.113663714818746 625 4648966
SGTC_950 1165-0508 94.1 µM 1.20645168775809 0.0839388351183062 no 339 0.113821688289858 580 6148369
SGTC_1387 3342-1166 1.8 µM 1.20642582858877 0.083943380776369 no 340 0.113826671027557 532 3418228
SGTC_492 tmb-8 126 µM 1.20557679650682 0.0840927307028481 no 341 0.113990355212717 428 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1928 4'-methoxychalcone 40.3 µM 1.20549684988045 0.0841068040723342 no 342 0.1140057766904 621 641818
SGTC_853 0419-0306 21 µM 1.20527794655842 0.0841453476718193 no 343 0.114048010127609 583 762713
SGTC_518 1021-0119 62.6 µM 1.20377015223434 0.0844111941897911 no 344 0.114339214568383 599 1097762
SGTC_2866 9034245 58.44 µM 1.20018094166488 0.0850465601762727 no 345 0.115034537688117 573 6462273
SGTC_1213 1315-0166 115 µM 1.19712788136473 0.0855898318222518 no 346 0.115628357057376 536 768401
SGTC_1728 st035614 33.7865 µM 1.19477332602688 0.0860105808455285 no 347 0.116087802322046 702 15945546
SGTC_2454 5-benzylidenerhodanine 10.36 µM 1.19385044240534 0.0861759177373692 no 348 0.116268237968149 684 1273210
SGTC_634 1611-4317 11.2 µM 1.1906832693174 0.0867451326848112 no 349 0.116888974181088 686 2843522
SGTC_1688 st021091 57.6 µM 1.19023048276602 0.0868267380189226 no 350 0.116977907646359 623 3656366
SGTC_2451 5856223 45.7 µM 1.18530783134006 0.0877176481351617 no 351 0.117947879125764 616 2179896
SGTC_2115 tiliquinol 12.7705 µM 1.1843610645987 0.0878897748360653 no 352 0.11813508293212 609 71208 A bioactive hydroxyquinoline.
SGTC_621 3584-0052 32.1 µM 1.18413089112044 0.0879316595099404 no 353 0.118180626776629 659 2273927
SGTC_2444 5485484 36.41 µM 1.18393616686438 0.0879671051096717 no 354 0.118219166067187 660 6790631
SGTC_1830 st055982 50.3 µM 1.183519416711 0.0880430018208924 no 355 0.118301677974735 632 455313 An antimicrobial agent.
SGTC_2077 5212015 200 µM 1.17323479536557 0.089931493613584 no 356 0.12035083106997 601 780900
SGTC_3226 9131256 49.47 µM 1.17138247845676 0.0902747969809531 no 357 0.120722535972932 515 17178073
SGTC_1736 st036774 51 µM 1.17121860396569 0.0903052158339154 no 358 0.120755459576188 677 1272247
SGTC_365 0121-0052 13.6 µM 1.16839717662356 0.0908301316566485 no 359 0.121323296643633 709 3101739
SGTC_2074 5212007 75.395 µM 1.16655509616562 0.0911740632098816 no 360 0.121695043135732 568 758611
SGTC_1312 1218-2183 165 µM 1.15452636541509 0.0934436989322376 no 361 0.124142217850159 688 6744073
SGTC_640 3381-0960 37.1 µM 1.15422574528649 0.0935009510447303 no 362 0.12420381507794 698 1745025
SGTC_2801 7907800 81.82 µM 1.15415111552611 0.0935151680498196 no 363 0.124219110068507 674 6620925
SGTC_2810 7959871 45.46 µM 1.15391974547423 0.0935592543027195 no 364 0.124266536560009 702 2974535
SGTC_1491 4138-0063 26.5 µM 1.14968220837328 0.0943694097702909 no 365 0.125137392418087 624 23883227
SGTC_321 4534-3890 65.3 µM 1.14900850828475 0.0944986866217426 no 366 0.125276236159166 666 699746
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 1.14842404163269 0.0946109461308483 no 367 0.125396776762906 696 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2483 5729050 27.16 µM 1.14785727075112 0.0947199006371823 no 368 0.125513745081977 763 2865180
SGTC_2064 5220758 200 µM 1.14437660681248 0.0953910424397574 no 369 0.126233742731855 711 788518
SGTC_897 1000-0139 31.4 µM 1.14388337314275 0.0954864302570407 no 370 0.126336003672667 668 6151020
SGTC_3152 9099253 49.47 µM 1.14363199278396 0.0955350723960612 no 371 0.126388143954548 757 25236131
SGTC_3218 9131285 49.47 µM 1.13849301360621 0.0965334661460285 no 372 0.127457337252764 752 17156417
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.13822957641149 0.0965848521297073 no 373 0.127512315809849 714 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1877 wortmannin 25 µM 1.13803090217582 0.0966236187584413 no 374 0.127553789436515 728 312145 A covalent inhibitor of PI 3-kinase.
SGTC_642 0335-0876 158 µM 1.13656610429908 0.096909792630655 no 375 0.127859858291867 683 6812350
SGTC_1810 st050138 53 µM 1.13526547918711 0.0971644136249431 no 376 0.128132050762187 634 3444541
SGTC_1811 st050069 61.5 µM 1.13293643049477 0.0976215933371903 no 377 0.128620474927838 646 3877702
SGTC_586 0957-0265 8.15 µM 1.13258208583858 0.0976912873045054 no 378 0.128694897534178 588 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2109 5483026 200 µM 1.13104061289739 0.0979948951058671 no 379 0.129018999029191 698 759335
SGTC_2030 5175110 200 µM 1.1274872453656 0.0986973976451518 no 380 0.12976826508423 687 2831986
SGTC_2305 7443522 69.23 µM 1.12506140554962 0.0991790999597984 no 381 0.130281507184309 727 5415886
SGTC_1329 1447-1697 50.6 µM 1.12389239565577 0.0994118447722188 no 382 0.130529338852104 680 2840515
SGTC_83 0170-0301 39.027 µM 1.12254367911998 0.0996808641388685 no 383 0.130815673381895 591 3089716
SGTC_2260 7964312 200 µM 1.12250691039633 0.0996882055882944 no 384 0.130823485510934 630 231951
SGTC_9 0092-0002 10.449 µM 1.12124184175209 0.0999410369574702 no 385 0.131092466872705 699 759368
SGTC_3266 9136860 49.47 µM 1.11733331197896 0.100725137478188 no 386 0.13192591865681 687 4871271 YPR165W RHO1
SGTC_3086 9117350 49.47 µM 1.11702262723071 0.100787656721063 no 387 0.131992325285872 618 2679265
SGTC_2897 9048598 12.99 µM 1.11575532248432 0.10104297021069 no 388 0.132263441344289 650 6467404
SGTC_145 3737-0113 38.366 µM 1.1087770254631 0.102457278444931 no 389 0.133763191954314 791 6849351
SGTC_2050 5263056 171 µM 1.10730681286684 0.10275707688777 no 390 0.134080649892886 763 763468 YGL055W OLE1
SGTC_406 estrone 100 µM 1.10459303490857 0.103312130427585 no 391 0.134667985237222 713 5870 A steroid.
SGTC_1808 st050063 61.5 µM 1.10328938127045 0.103579541534023 no 392 0.134950758243854 701 4011993
SGTC_3264 9137442 49.47 µM 1.10238284625205 0.103765789789219 no 393 0.135147632924426 661 17015726
SGTC_1251 0490-5699 265 µM 1.09911878393652 0.10443840570502 no 394 0.135858128833675 756 3883818
SGTC_821 1114-0266 29.2 µM 1.09670168545054 0.104938522169105 no 395 0.136385909716093 683 3123235
SGTC_2493 resveratrol 26.09 µM 1.09319708129835 0.105666727830434 no 396 0.137153639131649 657 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1968 st069590 43.6 µM 1.09290151081662 0.10572830971881 no 397 0.137218522440686 680 6384066
SGTC_2891 9063876 19.48 µM 1.09205768425434 0.105904263113681 no 398 0.137403873679935 642 6472478
SGTC_2439 5492030 7.2 µM 1.08627678717137 0.107115379975236 no 399 0.138678276850907 701 5722370
SGTC_427 1354-0053 47.3 µM 1.08594723587321 0.107184721760724 no 400 0.138751168482795 697 6813657
SGTC_156 3474-0145 5.642 µM 1.08294132812371 0.107818697487335 no 401 0.139417233116699 737 2265471
SGTC_2847 9005661 71.43 µM 1.07547479911799 0.109405138519391 no 402 0.141081104524327 615 2991449
SGTC_1813 st051246 8.6015 µM 1.07507383393346 0.109490804960224 no 403 0.141170836631262 694 5291959
SGTC_311 1315-0136 58 µM 1.0725169255005 0.110038223111788 no 404 0.141743957946672 742 6759207
SGTC_1755 st041960 45.185 µM 1.07199348098012 0.110150531044705 no 405 0.141861480105843 729 2257073
SGTC_2594 a-mangostin 100 µM 1.07179751459758 0.110192597868095 no 406 0.141905494847473 754 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_3080 9117754 49.47 µM 1.07068565637559 0.110431491380939 no 407 0.142155397180997 805 9550191
SGTC_2669 eugenol 100 µM 1.07052775758219 0.110465447554864 no 408 0.142190910804593 677 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2925 9010536 32.5 µM 1.06934348299059 0.110720364722034 no 409 0.142457461930327 797 2994177
SGTC_2941 9056145 11.23 µM 1.0679030511242 0.111030988021199 no 410 0.142782123037277 644 2119517
SGTC_959 1222-0044 107 µM 1.06441709135396 0.111785302820434 no 411 0.143569897294248 742 6083612
SGTC_1012 4112-3522 18 µM 1.06331430107566 0.112024693244133 no 412 0.143819720933848 751 3112398
SGTC_1606 st000094 49.2 µM 1.06324590163896 0.112039553252212 no 413 0.143835225642613 792 1242210
SGTC_3313 9133968 57.047 µM 1.06287099377524 0.112121028280114 no 414 0.143920229372367 780 1494643
SGTC_1142 3253-1408 9.78 µM 1.05762199649714 0.11326619083704 no 415 0.145113905057731 742 256655
SGTC_2090 5301565 104.445 µM 1.056023078481 0.113616675594471 no 416 0.145478835578327 812 2056344
SGTC_169 k015-0017 16.025 µM 1.05404881806683 0.114050501715825 no 417 0.14593028357737 672 1840002
SGTC_873 0591-4978 488 µM 1.05184437706705 0.11453630093145 no 418 0.146435477550654 819 3305145
SGTC_2230 bromochlorosalicylanilide 954.5 nM 1.04828267726861 0.115324312287611 no 419 0.147254194154454 685 77254
SGTC_2162 5663267 200 µM 1.04539048908323 0.115967026074156 no 420 0.147921265320835 791 6456493
SGTC_506 n9-isopropylolomoucine 153 µM 1.04056631083607 0.117044725324543 no 421 0.149038436759173 774 6610355
SGTC_2736 butenafine 14.65 µM 1.03642441030693 0.117975653220112 no 422 0.150002093585954 797 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_4 0960-0234 25.671 µM 1.03608755384212 0.118051594286964 no 423 0.15008064906826 731 6821112
SGTC_626 0214-0009 33 µM 1.03515044817924 0.118263037657908 no 424 0.15029932790508 791 3437874
SGTC_1435 4092-0789 56.7 µM 1.03454582395671 0.11839960378229 no 425 0.15044053298212 774 2248285
SGTC_1494 4358-1428 177 µM 1.02996836886423 0.119437128180207 no 426 0.151512427172219 812 1564571
SGTC_788 1182-0090 188 µM 1.02935111211863 0.119577524707118 no 427 0.151657356602146 887 5715185
SGTC_607 4491-0986 66.8 µM 1.02863655854162 0.119740196966339 no 428 0.151825245978991 806 698981 YDR232W HEM1
SGTC_940 3232-1287 54.8 µM 1.02657669528506 0.12021000990568 no 429 0.152309916182136 790 1585493 YIL048W NEO1
SGTC_2045 5106652 78.05 µM 1.02573616587495 0.120402090209269 no 430 0.152507981111256 790 673349
SGTC_2696 st077691 74.316 µM 1.02571615866792 0.120406664948836 no 431 0.152512697752507 696 757133
SGTC_769 0302-0231 76 µM 1.01841471101301 0.122084356373697 no 432 0.154240456983467 861 571869 YER009W NTF2
SGTC_3100 9120536 49.47 µM 1.01506635029301 0.122859191344959 no 433 0.155037100260914 679 16421196
SGTC_1540 guanosine 70.6 µM 1.01413576695868 0.12307514613154 no 434 0.155258986639903 745 6802 Guanosine is a purine nucleoside
SGTC_847 0342-0274 5.54 µM 1.01332169695574 0.123264280457126 no 435 0.155453263616946 817 18097
SGTC_1641 st009299 47.1 µM 1.00673238811569 0.124802683647696 no 436 0.157031696727552 745 4046054
SGTC_1971 st069429 63.5 µM 1.005374950867 0.125121263420743 no 437 0.157358168437933 783 1246522 YGL099W LSG1
SGTC_254 nsc-64875 3.808 µM 1.0037396228902 0.125505815623965 no 438 0.157752066620942 822 56993
SGTC_1416 3966-0321 25.3 µM 1.00248659766563 0.125801025793334 no 439 0.158054318164761 819 582530 YLR208W SEC13
SGTC_1872 amphotericin b 148 nM 1.00050855526686 0.126268033677241 no 440 0.158532229735333 840 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2346 9031566 143.75 µM 0.999344848879696 0.126543343906709 no 441 0.158813833252402 809 4771086
SGTC_2646 retinol 96.75 µM 0.996718289932068 0.127166272666462 no 442 0.15945063465841 785 445354 A vitamin A analog and teratogen.
SGTC_226 1,3-diallylurea 8.28947 mM 0.996200333915406 0.127289365311545 no 443 0.159576408604284 767 74537 YKL182W FAS1
SGTC_1496 4469-0713 57.4 µM 0.995333071464869 0.127495656426779 no 444 0.15978714908885 805 746691
SGTC_782 0083-0095 30.5 µM 0.993568252647406 0.127916162098235 no 445 0.160216553310468 847 3591729 An indicator and reagent.
SGTC_1111 tnp00062 510.699 nM 0.991632776579325 0.12837843735772 no 446 0.160688347182738 842 676306
SGTC_213 1246-0773 967 nM 0.990618145073533 0.128621237995672 no 447 0.160936037043859 836 6251622
SGTC_2491 paeonol 100 µM 0.99043637713732 0.128664768575777 no 448 0.160980436185507 781 11092 Increases levels of cortical cytochrome oxidase.
SGTC_755 1995-0008 37.3 µM 0.990089766471509 0.128747804743689 no 449 0.161065122426164 837 689533
SGTC_2616 abietic acid 100 µM 0.989643086577005 0.128854868926161 no 450 0.161174301117922 850 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_3048 9093155 49.47 µM 0.987564505617814 0.129353893826069 no 451 0.161682988393851 758 25236002
SGTC_2780 5215298 71.43 µM 0.986045723775373 0.129719368165876 no 452 0.162055337983525 861 2834131
SGTC_2116 5511452 16.8835 µM 0.98404625691522 0.130201602417641 no 453 0.162546384820575 831 870744
SGTC_3238 9133470 49.47 µM 0.982236006309085 0.130639269909489 no 454 0.162991796417239 814 3534688
SGTC_1531 st059297 52.4 µM 0.982154134479035 0.130659088220078 no 455 0.163011959691926 836 7566702
SGTC_2695 st077686 51.995 µM 0.982030857500917 0.130688933191906 no 456 0.163042323224738 772 2876092
SGTC_1158 4092-0494 91.8 µM 0.980352468141172 0.131095734927037 no 457 0.163456081869818 849 1148199
SGTC_1116 jasmonic acid 1.58368 µM 0.979510347100234 0.131300174292886 no 458 0.163663939306013 831 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.979225691467497 0.131369329103791 no 459 0.163734238529394 1037 16725076
SGTC_1828 st055811 49 µM 0.979181055396767 0.131380175360965 no 460 0.16374526373573 796 5877589
SGTC_2259 7964009 200 µM 0.97141480320834 0.133276739528791 no 461 0.165670879940516 780 313134
SGTC_2589 lobaric acid 100 µM 0.971188677618434 0.133332241511357 no 462 0.165727165526664 797 73157 A novel microtubule depolymerizer.
SGTC_1141 3253-0389 52.6 µM 0.968642520684518 0.133958287234036 no 463 0.166361790183586 833 5402031
SGTC_374 0880-0231 82.3 µM 0.96805895372748 0.134102057991971 no 464 0.166507463868672 845 6833587
SGTC_507 nimesulide 162 µM 0.966665800894179 0.13444571126098 no 465 0.166855564343915 850 4495 A COX2 inhibitor.
SGTC_762 1165-0429 115 µM 0.966598376807602 0.134462358291787 no 466 0.166872423181261 836 5967793
SGTC_652 0437-0092 114 µM 0.96317036465421 0.135310601105719 no 467 0.167731017323759 814 3091274
SGTC_827 3253-0474 693 µM 0.957619341195746 0.136691936080428 no 468 0.169127371315631 891 5402065
SGTC_2375 9072683 200 µM 0.955867735283217 0.137129805673754 no 469 0.169569530811522 944 16798029
SGTC_568 1193-0097 7.48 µM 0.954975772988155 0.137353147833596 no 470 0.16979497439902 839 3646150
SGTC_1238 0333-0287 48.8 µM 0.951736634772649 0.138166297346032 no 471 0.170615282491119 848 7226
SGTC_799 1310-0557 151 µM 0.951072738859308 0.138333365503297 no 472 0.170783726163637 848 5354492
SGTC_759 3486-0358 89.3 µM 0.950242522166108 0.138542481666932 no 473 0.170994518453767 917 875103
SGTC_2338 7999974 200 µM 0.948191024584966 0.13906013914475 no 474 0.171516107776834 923 315925
SGTC_1258 0671-0043 57.1 µM 0.940368721681256 0.141046023680709 no 475 0.173514230200302 855 4298767
SGTC_669 0108-0021 26.2 µM 0.940055952512189 0.141125825747522 no 476 0.173594430502775 960 17201
SGTC_2201 6605497 169.863 µM 0.939991478113745 0.141142279992277 no 477 0.173610965966577 871 670741
SGTC_2492 derrusnin 100 µM 0.937931911274151 0.141668578053854 no 478 0.174139701241675 785 1715307 Part of coumarin class of compounds.
SGTC_2200 6600604 21.907 µM 0.936471778459864 0.142042502128229 no 479 0.174515168204772 871 2904777
SGTC_2497 7-hydroxyflavone 100 µM 0.934146404637053 0.142639383086119 no 480 0.175114188799469 804 5281894
SGTC_848 0368-0089 85.6 µM 0.929559312238936 0.143821772026892 no 481 0.176299651111657 894 762535
SGTC_2496 diffractaic acid 79.83 µM 0.928196724587428 0.144174268796363 no 482 0.176652766585739 907 94870 An apoptosis inducer which activates caspases.
SGTC_3347 9188721 44.724 µM 0.927786229667038 0.144280576505075 no 483 0.176759234208748 832 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2811 7967822 32.47 µM 0.926471194310161 0.144621492797256 no 484 0.177100580153577 867 2232244
SGTC_2603 homopterocarpin 100 µM 0.924739916202094 0.145071144771894 no 485 0.177550605466649 865 101795 A weak amylase inhibitor.
SGTC_2717 st081029 62.2815 µM 0.924541413797552 0.145122760388264 no 486 0.177602249904498 864 5292846
SGTC_1885 st057546 99.9 µM 0.923994406263291 0.14526506005082 no 487 0.17774461408933 922 702008
SGTC_2014 4013930 200 µM 0.923350113350536 0.145432788102162 no 488 0.177912390079644 945 64556
SGTC_3014 9081533 49.47 µM 0.920888146193591 0.146074908756345 no 489 0.178554413992804 904 21367265
SGTC_475 α-linolenic acid 10 µM 0.919289211585205 0.146492955266789 no 490 0.178972159611108 939 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2545 solidagenone 89.61 µM 0.917714652162693 0.146905412882026 no 491 0.179384137356398 670 6708572 An anti ulcer agent
SGTC_3207 9114163 49.47 µM 0.916169704074872 0.147310870150283 no 492 0.179788946441277 944 849233
SGTC_774 k060-0086 136 µM 0.913403890895949 0.148038603688112 no 493 0.180515079983482 963 5911235
SGTC_1898 st060199 18.6 µM 0.911195629675971 0.148621360216956 no 494 0.181096153168589 877 688866
SGTC_2894 9048625 32.47 µM 0.908794768857104 0.149256681332425 no 495 0.181729234196872 907 4092861
SGTC_1487 3970-0795 2.82 µM 0.903743978747872 0.150599145083747 no 496 0.183065586681681 933 3765103
SGTC_2861 9024595 19.48 µM 0.902489726284181 0.150933758993854 no 497 0.183398388262069 855 16482810
SGTC_862 0452-0056 10.2 µM 0.901209549743873 0.151275798933738 no 498 0.183738457194251 894 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_3253 9135987 49.47 µM 0.900330346948671 0.151511004365831 no 499 0.183972237963613 856 4182430
SGTC_1504 k297-0033 30 µM 0.899208114028186 0.151811578573072 no 500 0.184270909605207 786 4388117
SGTC_2097 5376186 200 µM 0.898431213370113 0.152019892352964 no 501 0.184477850983611 916 742755
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.896355578247971 0.152577372304319 no 502 0.185031442149839 921 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_3328 9140624 29.0385 µM 0.895930675011436 0.152691661060467 no 503 0.185144894925614 938 4904392
SGTC_2215 7188065 200 µM 0.895648493123033 0.152767592575995 no 504 0.185220263758607 906 940217
SGTC_3012 9080433 71.4286 µM 0.894748851522017 0.153009841727774 no 505 0.185460678997779 972 17688859
SGTC_2650 prasterone 100 µM 0.891995522265467 0.153752820355356 no 506 0.186197666229994 879 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_1590 st077108 57.8 µM 0.891014608334552 0.154018093409777 no 507 0.18646066662589 916 5489485
SGTC_2474 5321570 43.32 µM 0.890727087802513 0.154095906260974 no 508 0.18653779955655 919 2841384
SGTC_1851 st056236 18.9 µM 0.890688624284487 0.154106317771228 no 509 0.186548119635732 964 5393171
SGTC_1092 toremifene 6.32 µM 0.89041864787277 0.154179409522664 no 510 0.186620566484168 1007 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2547 epiafzelechin trimethyl ether 100 µM 0.890322614231747 0.15420541460728 no 511 0.186646340841448 761 6708630 An antioxidant.
SGTC_2711 st079103 59.1 µM 0.889568374679178 0.154409757056183 no 512 0.186848846938874 914 54693780
SGTC_2167 5876490 200 µM 0.887439743641388 0.154987421849355 no 513 0.187421096986631 945 686534
SGTC_2807 7945238 51.95 µM 0.886105968917422 0.155350106055193 no 514 0.187780213448166 918 17148797
SGTC_1044 1222-0021 1.78 µM 0.886071341899681 0.155359529395586 no 515 0.187789542367219 899 4306703
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.885445840147471 0.155529817376557 no 516 0.18795810905652 812 88881 An O-methylated flavonoid and antioxidant.
SGTC_2765 myclobutanil 7.74 µM 0.883576460469112 0.156039475066773 no 517 0.18846244539291 911 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_191 3914-0123 66.505 µM 0.883048961831496 0.156183488365957 no 518 0.188604909070632 798 3144412
SGTC_257 daunorubicin 18.5 µM 0.880623874082862 0.156846692080941 no 519 0.189260716154358 939 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2975 9084847 53.72 µM 0.879751430480689 0.157085737198109 no 520 0.189496990667585 923 27211724
SGTC_1967 st070177 51.4 µM 0.878985299624984 0.15729585065408 no 521 0.189704623249699 906 5729214
SGTC_1053 3366-3204 134 µM 0.878530688900654 0.157420616179409 no 522 0.189827895479533 935 3632071 YPR165W RHO1
SGTC_174 3553-0389 74.3 µM 0.876505366450529 0.157977245462015 no 523 0.190377680145169 881 738071
SGTC_2372 9071633 200 µM 0.876288794015514 0.158036843509927 no 524 0.190436527719176 1002 21321366
SGTC_793 0488-0545 106 µM 0.876084498871247 0.158093076526616 no 525 0.190492049516075 922 292548
SGTC_2638 epoxomicin 18 µM 0.876026386218736 0.158109074654661 no 526 0.190507844751023 974 9915668 A protesome inhibitor.
SGTC_485 niflumic acid 177 µM 0.874328768182828 0.158576889484299 no 527 0.190969618446772 915 4488 A COX2 inhibitor.
SGTC_926 2268-1401 59.4 µM 0.873294395818315 0.158862377417924 no 528 0.191251317193664 974 2931578
SGTC_2397 5161689 200 µM 0.87181407938536 0.159271532062343 no 529 0.191654906239181 950 2259942
SGTC_2359 9039622 200 µM 0.869538191022157 0.1599019251126 no 530 0.192276414183189 983 6463596
SGTC_817 1391-0715 46 µM 0.869508694868569 0.159910105881816 no 531 0.192284477184239 886 1353946
SGTC_2606 farnesol 9.78 µM 0.869315397848238 0.15996372365767 no 532 0.192337321533411 928 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2708 st078559 56 µM 0.8689067827025 0.160077106235949 no 533 0.192449059681507 859 17250902
SGTC_353 1988-1175 58.3 µM 0.867644604100169 0.160427667462372 no 534 0.192794460200022 893 2788357
SGTC_1620 st003704 16.5 µM 0.865429912107678 0.161043993943437 no 535 0.19340143460488 970 2834414
SGTC_2013 4024628 200 µM 0.865091855092848 0.161138207562873 no 536 0.193494187399475 901 5230760
SGTC_2027 5150920 200 µM 0.864118883603957 0.161409567115707 no 537 0.193761293247388 946 786715
SGTC_808 0711-0032 135 µM 0.863557240842704 0.16156634359683 no 538 0.19391558099597 972 4252555
SGTC_3173 9105693 49.47 µM 0.862553547859497 0.161846760739219 no 539 0.194191489860193 988 17096658
SGTC_1145 3546-0597 10.2 µM 0.860175789470958 0.162512336362872 no 540 0.194846074128389 960 875334
SGTC_6 0844-0013 19.835 µM 0.858398895264031 0.163010880877074 no 541 0.195336118703084 1138 1584900
SGTC_1132 3456-3614 2.5 µM 0.856941725179178 0.163420461332012 no 542 0.195738545737154 1047 3125502
SGTC_1401 3807-4679 7.6 µM 0.856310640234948 0.163598053549493 no 543 0.195912988682226 925 3291456
SGTC_1763 st044482 94.5 µM 0.855723693465073 0.163763337369597 no 544 0.196075315695664 974 88505
SGTC_3201 9113999 49.47 µM 0.854163106737287 0.164203324575487 no 545 0.196507310891698 904 16649224
SGTC_1118 chelidonine 707.474 nM 0.853740234425114 0.164322679834978 no 546 0.196624467902513 1027 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_2245 6637752 200 µM 0.853668664247797 0.164342886005603 no 547 0.196644300646185 904 681890
SGTC_1809 st050081 57.6 µM 0.85287503141713 0.164567057696316 no 548 0.196864304697425 969 5036894
SGTC_3056 9094900 49.47 µM 0.852494708014088 0.164674555082761 no 549 0.196969787472804 964 25236784
SGTC_2055 5235184 200 µM 0.84971551295772 0.165461467639835 no 550 0.19774163578215 943 2836034
SGTC_2843 9000894 45.46 µM 0.846705536055411 0.166316463989463 no 551 0.19857963611528 866 2242070
SGTC_1427 4048-4900 550 nM 0.84654150570027 0.166363139321911 no 552 0.198625364868642 1007 24132586
SGTC_1444 4112-3581 28 µM 0.846139682912759 0.166477514944106 no 553 0.19873741276528 992 2877249
SGTC_1702 st027038 51 µM 0.845880124107959 0.16655142324876 no 554 0.198809810743409 987 5521182
SGTC_1082 camptothecin 424.86 nM 0.845596444164356 0.16663222416816 no 555 0.198888954941959 943 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2087 5276107 200 µM 0.845201365452728 0.16674479708424 no 556 0.198999210047918 979 144405
SGTC_3210 9128157 49.47 µM 0.844972495878554 0.166810033152296 no 557 0.199063097808458 861 17590849
SGTC_760 0568-0725 82.9 µM 0.844729537527113 0.166879303043923 no 558 0.199130931899159 1017 3916171
SGTC_2792 7535235 81.82 µM 0.844305141009466 0.167000347305589 no 559 0.199249457016386 904 1281891
SGTC_2629 bisabolol 100 µM 0.84351298053445 0.16722643480979 no 560 0.199470804590386 981 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3150 9097574 49.47 µM 0.842135668721885 0.167619997638471 no 561 0.199856008927525 972 17217476
SGTC_2935 9038016 29.96 µM 0.841612966454311 0.167769514325635 no 562 0.200002314486452 1009 6463195
SGTC_310 1273-0058 1.06 µM 0.841499876775394 0.167801874427819 no 563 0.200033977017121 1059 2734232
SGTC_201 4262-0159 12.803 µM 0.840441104277206 0.168105032330087 no 564 0.200330555317459 941 1341029
SGTC_877 0771-0151 33.1 µM 0.840358083445228 0.168128818542933 no 565 0.200353821881076 992 6166523
SGTC_2395 5646831 180.19 µM 0.837006336196271 0.169090932500958 no 566 0.201294503236722 960 6808628
SGTC_2963 9082507 9 µM 0.835057157002613 0.169652064115325 no 567 0.201842763723635 927 16459611
SGTC_1239 0337-0584 35.4 µM 0.833750289415997 0.170028954560884 no 568 0.202210856514726 1040 914301 YML130C ERO1
SGTC_85 0868-0259 160.055 µM 0.833082666889828 0.17022169865233 no 569 0.202399054191256 932 83173
SGTC_1059 3448-6867 171 µM 0.832158046511111 0.170488869691001 no 570 0.202659870504417 1019 3934407
SGTC_2302 7771753 200 µM 0.83180201836253 0.170591816354262 no 571 0.202760352229879 997 2203047
SGTC_1686 st019653 115.5 µM 0.829628553315894 0.171221143473484 no 572 0.203374413941994 1010 97252
SGTC_113 0099-0221 2.5 µM 0.828960266945025 0.171414943904258 no 573 0.203563445435262 957 89219
SGTC_2490 carminic acid 95.39 µM 0.827552433721499 0.17182366861183 no 574 0.20396200789794 957 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2744 captopril 92.04 µM 0.827213277025653 0.171922226155235 no 575 0.204058093790039 968 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_3183 9108214 49.47 µM 0.82613275717781 0.172236461414333 no 576 0.204364393742213 921 4974831
SGTC_1021 4476-0760 85.3 µM 0.824797374644715 0.17262532148806 no 577 0.20474331871596 999 746768
SGTC_3083 9117465 49.47 µM 0.823964443752899 0.172868152124814 no 578 0.204979880683197 1051 16420915
SGTC_2034 5197015 53.07 µM 0.823856440627199 0.17289965502755 no 579 0.205010566710879 988 780676
SGTC_792 4534-1957 155 µM 0.823383381234418 0.173037682504913 no 580 0.205145005303144 1000 1717904
SGTC_1557 sumaresinolic acid 42.3 µM 0.821946306169061 0.173457417194525 no 581 0.205553728374152 970 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_602 3130-1533 38.1 µM 0.821786304194056 0.173504189941523 no 582 0.205599264933869 1030 720941
SGTC_3244 9134489 49.47 µM 0.816965393652 0.174917230992157 no 583 0.206974102481587 1008 16584271
SGTC_2246 7293507 91.5585 µM 0.816469021062346 0.175063134641195 no 584 0.20711596732516 1063 887656
SGTC_2763 lisinopril 49.32 µM 0.816363179341721 0.175094255716991 no 585 0.207146224659689 980 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_276 colchicine 750 µM 0.81587993364147 0.175236391022558 no 586 0.207284404977984 1034 2833 A microtubule depolymerizer.
SGTC_1955 wogonin 32.4 µM 0.81560936557819 0.17531600416986 no 587 0.207361795590351 994 5281703 A flavanone.
SGTC_3073 9114972 49.47 µM 0.814252826917285 0.175715503782603 no 588 0.207750063941565 944 41905075
SGTC_2385 9074692 200 µM 0.813029726714514 0.176076199901413 no 589 0.208100507424444 991 17046906
SGTC_1412 3909-8563 178 µM 0.811947448730643 0.176395757698886 no 590 0.208410893193681 1103 23767530
SGTC_2433 5607874 27.82 µM 0.811479468901778 0.176534048882182 no 591 0.208545189323858 1037 2252428
SGTC_962 1254-0300 21.5 µM 0.810164274768373 0.176923064608063 no 592 0.208922883553456 1007 7340576
SGTC_1465 k213-0056 144 µM 0.809915101077639 0.176996827639215 no 593 0.208994486020145 966 24048857 YMR208W ERG12
SGTC_1794 st048918 76.9 µM 0.807343881234378 0.17775912183277 no 594 0.209734194569897 978 672303
SGTC_305 1682-2595 20.8 µM 0.807151586637618 0.177816214879904 no 595 0.20978957717563 1034 226033
SGTC_181 1447-1644 8.07 µM 0.805203154415466 0.178395364557015 no 596 0.210351228239678 1025 534600
SGTC_2994 9053520 71.4286 µM 0.804225749135064 0.178686334433591 no 597 0.2106333052629 1030 4647384
SGTC_1834 st055981 52.8 µM 0.802177221048566 0.179297142352414 no 598 0.211225225504971 1054 471719 YDL150W RPC53
SGTC_1792 st045773 43.6 µM 0.801847758932236 0.179395500220256 no 599 0.211320514166051 1006 2919270
SGTC_2832 7992762 51.95 µM 0.800580080480586 0.179774270194021 no 600 0.211687393163353 926 2985177
SGTC_662 k832-1615 104 µM 0.800322973976113 0.179851152349703 no 601 0.211761847838684 991 5878478
SGTC_273 hydroxyurea 18.1 mM 0.799863536804804 0.179988588544231 no 602 0.211894932976142 1104 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1347 1493-0251 600 nM 0.799255732661626 0.180170508588247 no 603 0.212071070725132 1082 3986378
SGTC_790 1575-0012 79.1 µM 0.79846922499222 0.180406087089571 no 604 0.212299122640312 1080 378741 YLR208W SEC13
SGTC_2555 cholic acid 100 µM 0.796987192337925 0.180850517403686 no 605 0.21272923484923 1012 6708657 Influences liver metabolism.
SGTC_206 4546-0025 72.014 µM 0.796883347709812 0.180881683921988 no 606 0.212759391466457 1089 6620745 YIL048W NEO1
SGTC_1978 st071761 42 µM 0.796034311192592 0.181136628489218 no 607 0.213006046397546 990 5147680
SGTC_2886 9058944 51.95 µM 0.795608892264678 0.181264455828466 no 608 0.213129698234422 910 4949929
SGTC_1611 st001856 99.4 µM 0.794300148812337 0.181658053349164 no 609 0.213510358716564 1020 647478
SGTC_293 4049-0273 38.5 µM 0.793682152350543 0.181844098191789 no 610 0.213690246497909 984 1380311
SGTC_982 1491-0518 27.5 µM 0.793119229655085 0.182013667025333 no 611 0.21385418009403 986 3091256
SGTC_3177 9107506 49.47 µM 0.792444192241419 0.182217138420868 no 612 0.214050860116369 1017 8897194
SGTC_650 1328-0195 38 µM 0.78958231474697 0.1830813504306 no 613 0.214885869957431 1065 2780821
SGTC_2564 betulinic acid 100 µM 0.789073677224414 0.183235212819147 no 614 0.215034472872137 1081 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_255 tunicamycin 200.472 nM 0.787927751230076 0.183582149782258 no 615 0.21536948377453 1047 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1384 3089-0840 101 µM 0.787094365597939 0.183834719945162 no 616 0.215613313735485 1019 1069836
SGTC_3132 9126706 49.47 µM 0.786322976840978 0.184068693795632 no 617 0.215839147384397 1015 850858
SGTC_392 N-ethylmaleimide 8.33 µM 0.786244425660697 0.184092529949835 no 618 0.215862151906912 1017 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3251 9135047 49.47 µM 0.78617035614461 0.184115007914645 no 619 0.215883845229423 1040 17682963
SGTC_84 0443-0269 128.823 µM 0.7852787720504 0.184385712048217 no 620 0.216145069593507 1044 6150058
SGTC_229 benomyl 22.8748 µM 0.785271040418624 0.184388060620576 no 621 0.216147335677128 1058 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_3162 9099653 49.47 µM 0.784255587845654 0.184696677775356 no 622 0.21644507680111 1040 25237511
SGTC_334 1502-1024 68.5 µM 0.782775489466272 0.18514708525382 no 623 0.216879481666582 1108 3296216
SGTC_1157 4092-0394 27.6 µM 0.782303320528966 0.185290913994773 no 624 0.217018167938077 1119 3659885
SGTC_227 fluconazole 33.516 µM 0.78086617296551 0.185729114441057 no 625 0.217440604651346 1092 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1882 5615643 20 µM 0.778155160299841 0.18655747732048 no 626 0.218238773710338 1036 2253075
SGTC_1281 0884-0031 11.8 µM 0.777155574168965 0.18686348204673 no 627 0.218533494619955 1100 1548255
SGTC_2318 6029776 164 µM 0.772572791254997 0.188270388653364 no 628 0.219887626138393 1056 818325
SGTC_2767 sibutramine 71.45 µM 0.769587432192471 0.189190394633371 no 629 0.220772331225385 1102 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.769587239323344 0.189190454159644 no 630 0.220772388447532 1082 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3342 9147791 14.508 µM 0.768734966094396 0.189453608605758 no 631 0.221025331461 1068 1838168
SGTC_1182 1222-0449 220 µM 0.76504409009136 0.190595829817439 no 632 0.222122645364888 1058 658318
SGTC_3265 9137266 49.47 µM 0.763728325071321 0.191004041713079 no 633 0.22251457873039 1067 17224265
SGTC_2537 larixol 68.93 µM 0.762084014363608 0.191514937004226 no 634 0.22300493149533 1112 6708759
SGTC_2415 st077333 57.7 µM 0.761913289289861 0.191568030043481 no 635 0.223055878960159 1139 2766255
SGTC_1871 st057448 67.3 µM 0.761359866832562 0.191740198434377 no 636 0.223221075839387 1132 691747
SGTC_1741 st038134 10.228 µM 0.760011941097879 0.192159931135544 no 637 0.223623723589143 1146 1272587
SGTC_3209 9113616 49.47 µM 0.759992326829223 0.192166042999749 no 638 0.223629585743296 1118 16649353
SGTC_1149 3909-7961 23.3 µM 0.759991162815367 0.192166405713652 no 639 0.2236299336371 1078 735261
SGTC_533 1222-0222 6.71 µM 0.759038939705894 0.192463264614406 no 640 0.223914631719938 1142 3982874
SGTC_2112 5488546 200 µM 0.755691849534911 0.193508954638871 no 641 0.224916985946764 1106 600757
SGTC_941 3237-0776 460 µM 0.754875978837842 0.193764371406691 no 642 0.225161700010531 1102 760008
SGTC_2199 6590217 200 µM 0.754487360183368 0.193886104730013 no 643 0.225278316162979 1064 703109
SGTC_2161 5662504 8.5105 µM 0.75356158478754 0.194176288095246 no 644 0.22555625932815 1047 2859334
SGTC_2645 abamectin 100 µM 0.752246392669919 0.194588988294929 no 645 0.225951449563895 1105 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_2166 5933061 31.504 µM 0.749806855555566 0.195355913837467 no 646 0.226685519611441 1306 2877375
SGTC_2816 7982706 58.44 µM 0.749480517778902 0.195458644817015 no 647 0.226783818390456 1089 2981853
SGTC_561 1550-0330 72.9 µM 0.749153802922711 0.195561527362536 no 648 0.226882254839493 1084 6812934
SGTC_29 0299-0004 12.984 µM 0.748591792485512 0.195738581430076 no 649 0.227051640249103 1028 16871 A napthoquinone isolated from Swertia calycina.
SGTC_884 0851-0618 334 µM 0.747930704581256 0.195946973057517 no 650 0.227250978040227 1124 9642473
SGTC_3318 9139014 38.6185 µM 0.746302389023633 0.196460833081905 no 651 0.227742384305563 1078 16643984
SGTC_1958 st076513 41.9 µM 0.745074437509705 0.196848886765967 no 652 0.228113360709084 1109 732122 YGL099W LSG1
SGTC_1969 st069479 40.1 µM 0.744648703856076 0.196983534156021 no 653 0.228242058378812 1083 3895485
SGTC_325 2810-4341 181 µM 0.743505746941483 0.197345294413742 no 654 0.228587771724804 1137 774970
SGTC_486 niguldipine 82 µM 0.743023103838623 0.197498177624191 no 655 0.228733846393803 1097 1236 A calcium channel blocker.
SGTC_717 1532-0246 73.2 µM 0.740650308234664 0.198250831021574 no 656 0.229452748093863 1113 9561992
SGTC_2025 5147754 141 µM 0.740079614397304 0.198432113690622 no 657 0.229625843721344 1134 315777 YLR208W SEC13
SGTC_1935 st074532 41.6 µM 0.739618161929593 0.198578768605557 no 658 0.229765859108881 1204 2829742
SGTC_3136 9095672 49.47 µM 0.739449864161325 0.198632271842282 no 659 0.229816936452665 981 17217380
SGTC_2364 9055074 200 µM 0.738508178150668 0.198931801907138 no 660 0.230102849676084 1115 6470630
SGTC_1951 sophoraflavanone G 9.2 µM 0.737689423932058 0.199192451118854 no 661 0.23035160019782 1170 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.736596698052488 0.1995406391018 no 662 0.230683821778588 1132 5282362
SGTC_112 phenothiazine 287.218 µM 0.736134079766151 0.199688158859771 no 663 0.230824552283417 1141 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2324 6149169 200 µM 0.735871879967649 0.199771798280177 no 664 0.23090433589184 1082 2888231
SGTC_2840 9008771 71.43 µM 0.73411139533876 0.200333922898014 no 665 0.231440424500012 1111 2992978
SGTC_2879 9041815 71.43 µM 0.732026248415785 0.201000940412029 no 666 0.232076273448395 1087 4942971
SGTC_694 1315-0438 43.2 µM 0.731219394089887 0.201259402077837 no 667 0.232322577958586 1057 6793154
SGTC_1987 st072290 61.9 µM 0.731146201597022 0.201282857865542 no 668 0.232344928268425 1133 54697379
SGTC_2295 7971645 200 µM 0.7290404193814 0.201958393447875 no 669 0.232988469137399 1109 2978226 YKL099C UTP11
SGTC_3045 9092950 49.47 µM 0.727362742810504 0.202497562666425 no 670 0.233501885819874 1166 44120432
SGTC_3124 9127567 49.47 µM 0.725708763605622 0.203029957577429 no 671 0.234008664112609 1108 17592030
SGTC_977 1348-1378 135 µM 0.725321735056288 0.20315465772305 no 672 0.234127337341053 1177 X977
SGTC_222 nsc-310342 10.666 µM 0.724553542383429 0.203402303899936 no 673 0.234362984298724 1108 432556
SGTC_3341 9147222 25.867 µM 0.724359611110837 0.203464850972284 no 674 0.234422494433568 1115 1939759
SGTC_2962 9082311 13.18 µM 0.723476943831322 0.203749675373251 no 675 0.234693457069835 1151 16459453
SGTC_2754 granisetron 64.02 µM 0.722503302687151 0.204064131316684 no 676 0.234992547775074 1148 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_898 1000-0849 28.3 µM 0.722091185481482 0.204197319452823 no 677 0.235119208568802 1156 6751807
SGTC_968 1309-0633 340 µM 0.720299408998877 0.204776987759869 no 678 0.235670334277334 1155 3761976
SGTC_1874 staurosporine 7.6 µM 0.720248412473515 0.204793500261339 no 679 0.235686030525504 1176 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2860 9025725 38.96 µM 0.719990326214941 0.204877079858215 no 680 0.235765475876547 1132 40546248
SGTC_1603 st002045 67.8 µM 0.719763010693447 0.204950711343811 no 681 0.235835461460112 1165 5887985
SGTC_2567 aureobasidin a 60 nM 0.719073021219686 0.205174307372442 no 682 0.236047964577526 1177 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2884 9058502 51.95 µM 0.719030292042602 0.205188158832663 no 683 0.236061127787501 1165 6471554
SGTC_1331 1472-0049 76.2 µM 0.718786141349756 0.205267315493769 no 684 0.236136348948067 1145 24051409
SGTC_1710 st031758 61.5 µM 0.718507560092722 0.205357657123476 no 685 0.236222194055907 1155 5394341
SGTC_1981 st071826 47 µM 0.718128690232586 0.205480559421471 no 686 0.236338970779777 1125 11838600
SGTC_742 0kpi-0133 140 µM 0.717721854828992 0.205612582133023 no 687 0.236464402532148 1170 2728852
SGTC_592 k241-0073 46.5 µM 0.717562203355451 0.20566440460437 no 688 0.236513634815513 1175 4230158
SGTC_3189 9110682 49.47 µM 0.716702559009098 0.205943576248498 no 689 0.236778823284978 1183 17122418
SGTC_431 k089-0097 107 µM 0.716627630761213 0.205967920029091 no 690 0.23680194536482 1142 5499420
SGTC_153 4077-0274 519.67 µM 0.716024376941664 0.206163976096443 no 691 0.23698814846671 1217 3121976
SGTC_3103 9120822 49.47 µM 0.7124411053824 0.207330809403186 no 692 0.238095834546757 1223 17141819
SGTC_296 1222-0039 74.9 µM 0.711281936148965 0.207709108025991 no 693 0.238454771543395 1138 5984176
SGTC_3214 9129694 49.47 µM 0.710925689056282 0.207825452280099 no 694 0.238565143018048 1139 17158655
SGTC_3246 9135460 32.98 µM 0.710704407550764 0.207897738437922 no 695 0.238633713909438 1111 41446951
SGTC_357 1325-0123 420 µM 0.710389168184019 0.208000743501492 no 696 0.238731419164032 1157 1098503
SGTC_3139 9095020 49.47 µM 0.710020215206615 0.208121337847644 no 697 0.238845800202247 999 25236292
SGTC_337 1315-0038 354 µM 0.709065495986676 0.208433584646202 no 698 0.239141916774712 1152 1626437
SGTC_3090 9117696 49.47 µM 0.708361174790306 0.208664114219103 no 699 0.23936049821239 1141 7923821
SGTC_1846 st056244 14.8 µM 0.708084906897726 0.2087545797785 no 700 0.239446265918303 1173 5393182
SGTC_1703 st026983 48.3 µM 0.706878045908812 0.209150044502152 no 701 0.239821134104415 1187 1104023
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.704528930419831 0.209921067317388 no 702 0.240551719988649 1127 279621
SGTC_217 ketoconazole 989 nM 0.702614574561415 0.210550627605491 no 703 0.241147988604282 1139 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_363 0455-0021 3.06 µM 0.702496133629945 0.210589614775969 no 704 0.241184906035174 1200 4597466
SGTC_1718 roemerine 11.9335 µM 0.701608397356731 0.210881965529956 no 705 0.241461706656291 1145 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1356 1502-0781 85.8 µM 0.701312332377553 0.210979519026441 no 706 0.241554059555298 1155 567702
SGTC_685 1278-0033 54.9 µM 0.699984006720679 0.211417528227537 no 707 0.241968646215403 1219 3590572
SGTC_2009 4012297 12.05 µM 0.698241508505415 0.211992915675254 no 708 0.24251308591766 1168 45595307
SGTC_425 3825-7017 13.1 µM 0.696604166718193 0.212534413295651 no 709 0.243025273764731 1213 3397440
SGTC_1477 0139-0234 16 µM 0.696464675544621 0.212580582788018 no 710 0.24306893596275 1182 620880
SGTC_1524 corynanthine 62.1 µM 0.696351058337469 0.212618192712784 no 711 0.243104502473085 1197 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1470 k295-0292 231 µM 0.696282787465291 0.212640793820222 no 712 0.243125875208098 1219 5045612
SGTC_2205 7238770 200 µM 0.695271112983222 0.212975873578073 no 713 0.243442706934891 1214 279867
SGTC_65 0798-0905 34.986 µM 0.695098567065878 0.213033053771639 no 714 0.243496766358234 1282 3602145
SGTC_1262 0737-0114 49.6 µM 0.69467091600161 0.213174812161657 no 715 0.24363077933724 1230 765919
SGTC_2080 5212524 12.4 µM 0.692021923612702 0.214054129005614 no 716 0.244461780589772 1175 260183
SGTC_2628 lathosterol 100 µM 0.69144316518196 0.214246524944413 no 717 0.244643542869047 1264 6710616
SGTC_919 tnp00227 403.569 nM 0.691389002330158 0.214264535379709 no 718 0.244660556734877 1204 1269246 A methoxyflavone. YNL221C POP1
SGTC_82 0054-0107 293.755 µM 0.691324621041658 0.21428594483365 no 719 0.244680781288372 1208 3104697
SGTC_1988 st071872 53.4 µM 0.690339298193656 0.21461376085289 no 720 0.244990420070572 1214 16414116
SGTC_1023 4482-3888 16 µM 0.689821916675651 0.214786009863552 no 721 0.245153092149183 1203 3303168
SGTC_2704 st078022 71.1 µM 0.689495590042156 0.21489469330692 no 722 0.245255723729878 1219 54697681
SGTC_1181 1222-0449 220 µM 0.689442006367306 0.21491254246139 no 723 0.245272578307736 1252 658318
SGTC_1452 4194-0072 190 µM 0.688711960419191 0.215155812431087 no 724 0.245502274006805 1244 1343545
SGTC_2217 6934799 96.0675 µM 0.688484196403714 0.215231741924809 no 725 0.245573959462815 1172 675606
SGTC_1820 st053765 18.6 µM 0.688050280717886 0.215376439051769 no 726 0.245710559307451 1187 3690829
SGTC_1417 3966-0327 90.4 µM 0.687953030961491 0.215408876503245 no 727 0.245741179840693 1251 651118
SGTC_3335 9143315 29.6265 µM 0.687770051716102 0.215469916527718 no 728 0.245798799133102 1192 4899691
SGTC_2571 chrysanthemic acid 100 µM 0.68741947593518 0.215586893082131 no 729 0.24590921403168 1162 2743 An insecticide.
SGTC_916 4466-0038 42 nM 0.68728808280274 0.215630744489536 no 730 0.24595060355122 1250 5722064 YGL116W CDC20
SGTC_2523 spermine 47.74 µM 0.687197147314444 0.215661096509749 no 731 0.24597925089127 1179 1103 A DNA binding polyamine.
SGTC_2443 5493264 126.67 µM 0.686419809120686 0.215920653871525 no 732 0.246224208218816 1204 5340055
SGTC_2793 7325131 81.82 µM 0.684656628643159 0.216510059667642 no 733 0.246780311825628 1193 4176441
SGTC_1604 st002052 72.4 µM 0.684246045655669 0.216647445148874 no 734 0.246909905337122 1244 6254834 YHR062C RPP1
SGTC_218 alverine citrate 93.75 µM 0.68267129195745 0.217174842022189 no 735 0.247407287013904 1216 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.682309275280261 0.217296188899145 no 736 0.247521704652502 1296 6728940
SGTC_1112 tnp00069 1.16933 µM 0.682162870583215 0.217345274421186 no 737 0.24756798480148 1246 145826
SGTC_2713 st079149 53.4 µM 0.681838421606183 0.217454076172976 no 738 0.247670563194062 1237 3103253
SGTC_2285 7945142 200 µM 0.681385884163486 0.21760588401868 no 739 0.247813676176425 1228 2970608
SGTC_1634 st006576 41 µM 0.679349945393825 0.218289614464464 no 740 0.248458078609927 1217 3915356
SGTC_466 geldanamycin 89.2 µM 0.678377623267621 0.218616586157238 no 741 0.248766146623485 1124 5288382 HSP90 inhibitor.
SGTC_1084 voriconazole 435 nM 0.677581867112618 0.218884392059107 no 742 0.249018423193579 1234 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2003 4023581 200 µM 0.677032149838624 0.219069505551469 no 743 0.249192778144103 1242 16641307
SGTC_901 1112-0062 60.1 µM 0.676659999121894 0.219194875818964 no 744 0.249310850790695 1238 1908457
SGTC_1334 1486-0610 236 µM 0.676556996827802 0.219229582555199 no 745 0.249343535690694 1222 3742339
SGTC_63 0099-0242 26.702 µM 0.675923072644561 0.219443253539138 no 746 0.249544743958109 1235 3898502 YLR359W ADE13
SGTC_802 4112-3352 742 µM 0.675895880823893 0.21945242151097 no 747 0.249553376602476 1262 704594
SGTC_1825 st052143 62.6 µM 0.674895727854565 0.219789785126212 no 748 0.249871007476318 1240 674173
SGTC_2845 9003024 42.97 µM 0.674745950917287 0.21984033230472 no 749 0.249918592447796 1272 2990173
SGTC_543 3844-1095 191 µM 0.674490759476595 0.219926470459038 no 750 0.249999679274407 1233 4230703
SGTC_1655 st012546 55.1 µM 0.674282230972855 0.219996872229969 no 751 0.250065949362395 1198 720985 YLR208W SEC13
SGTC_869 0564-0080 44.1 µM 0.673903030901782 0.220124927937636 no 752 0.250186482532278 1216 6843321
SGTC_2634 4'-methoxyflavone 100 µM 0.673322285973455 0.220321128113569 no 753 0.250371138801189 1216 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_440 fluspirilene 35.1 µM 0.673202617184831 0.220361569741209 no 754 0.250409198202592 1296 3396 An atypical antipsychotic.
SGTC_12 0849-0099 9.267 µM 0.673178477363178 0.220369728221035 no 755 0.250416875990999 1178 6071388
SGTC_1876 myriocin 605 nM 0.672816318906668 0.220492146861472 no 756 0.250532077236066 1260 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1041 0206-0046 107 µM 0.671290118400772 0.221008468868968 no 757 0.251017864230882 1237 50494
SGTC_432 NS 1619 61.3 µM 0.670993539944459 0.22110888322875 no 758 0.25111232244697 1239 4552 A K+/calcium channel activator.
SGTC_1230 0170-0365 3.77 µM 0.667412184655282 0.222323503487268 no 759 0.252254442507383 1319 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1701 st028638 40.4 µM 0.665648834353704 0.222922941254058 no 760 0.252817792332235 1230 3490878
SGTC_1512 0259-0544 12.2 µM 0.665548893735762 0.222956942867767 no 761 0.252849740880168 1238 18476
SGTC_3095 9117207 49.47 µM 0.665431016667135 0.222997050584421 no 762 0.252887425999971 1205 17015229
SGTC_138 0850-0259 40.9225 µM 0.665248318645155 0.223059221774048 no 763 0.25294584012141 1276 6813004
SGTC_2751 anetholtrithion 17.25 µM 0.665118521898018 0.223103396930698 no 764 0.252987344408218 1225 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1729 st035615 45.989 µM 0.665111593958346 0.223105754932747 no 765 0.252989559812507 1219 17385451
SGTC_3277 9138724 49.47 µM 0.664933709568733 0.22316630474156 no 766 0.253046446863767 1184 15943418
SGTC_1635 st007035 42.4 µM 0.664341169911015 0.223368065925043 no 767 0.253235988326085 1259 3716403
SGTC_1922 5578187 25 µM 0.664017270208153 0.22347839841695 no 768 0.253339628844212 1290 1350412
SGTC_930 2810-3379 265 µM 0.662491416755451 0.223998578667518 no 769 0.253828166925502 1310 1015764
SGTC_1308 1187-1617 41.4 µM 0.662189526713113 0.224101577762203 no 770 0.253924882733842 1250 2882570
SGTC_718 1130-0073 349 µM 0.661415871840085 0.224365656739778 no 771 0.254172824999689 1314 6740020
SGTC_1552 6-methylflavone 10.6 µM 0.659887216700899 0.224887966105661 no 772 0.25466310409651 1222 689013
SGTC_1626 st003712 1.76 µM 0.658805189479758 0.225258088326846 no 773 0.255010437226678 1235 24207035
SGTC_3269 9137823 49.47 µM 0.658671503337691 0.225303841435237 no 774 0.255053367969755 1190 17682936
SGTC_3261 9137475 49.47 µM 0.658594972400501 0.225330035959571 no 775 0.255077946115468 1153 17027690
SGTC_587 k089-0003 57 µM 0.657511516707631 0.225701059284722 no 776 0.255426034118567 1206 9659696
SGTC_2413 inermin 26.06 µM 0.65741468542248 0.225734235431592 no 777 0.255457155738044 1353 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_659 k018-0002 107 µM 0.656662338873954 0.22599209690916 no 778 0.255699027748485 1243 6797879 YHR007C ERG11
SGTC_537 1334-0398 209 µM 0.655927735904062 0.226244037499574 no 779 0.255935310701945 1243 5846986
SGTC_875 0709-0210 25.7 µM 0.655065971204676 0.226539791835407 no 780 0.256212640013235 1276 6251364
SGTC_971 1315-0384 26.7 µM 0.654831239526081 0.226620388653328 no 781 0.256288207467869 1249 6769120
SGTC_1043 0916-0009 19.3 µM 0.654598681168514 0.226700255204037 no 782 0.256363086718138 1299 3101130
SGTC_3190 9110366 49.47 µM 0.654088446109248 0.226875538754067 no 783 0.256527412384783 1188 17123768
SGTC_223 busulfan 5 mM 0.653129356461728 0.22720522633683 no 784 0.256836444034414 1262 2478 A DNA alkylator.
SGTC_2222 6885208 172.143 µM 0.652803263704009 0.227317382378823 no 785 0.256941559649135 1232 609514
SGTC_161 4065-0411 162.148 µM 0.652489352507217 0.227425378168434 no 786 0.257042769692619 1274 1906281 YLR208W SEC13
SGTC_3119 9125183 49.47 µM 0.651691234074967 0.227700087306842 no 787 0.257300189327545 1131 22695334
SGTC_3041 9091929 49.47 µM 0.649204470743678 0.228557217770616 no 788 0.258103111180811 1317 25236887
SGTC_2081 5214970 32.255 µM 0.647954696241755 0.228988669812002 no 789 0.258507126221457 1237 2063512
SGTC_1060 3448-7350 82 µM 0.645948986195866 0.229682043104493 no 790 0.259156196787721 1248 570178
SGTC_1398 3558-0053 112 µM 0.645548125873361 0.229820761245509 no 791 0.259286020686556 1199 4532369
SGTC_455 paf C-16 10 µM 0.645403346381448 0.229870873870762 no 792 0.2593329176929 1245 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2823 7987624 58.44 µM 0.645220209753169 0.229934271840132 no 793 0.25939224562927 1307 2239440
SGTC_1506 4226-2149 212 µM 0.645017293007095 0.230004528689956 no 794 0.259457989611454 1304 991114
SGTC_2837 9008476 45.46 µM 0.644761775093937 0.230093014983514 no 795 0.259540788341779 1301 2992805
SGTC_1122 capsaicin 818.572 nM 0.643900119837502 0.230391548052199 no 796 0.259820102040931 1329 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1227 3909-8010 46.6 µM 0.643456969771908 0.230545168161007 no 797 0.259963813694841 1276 15982272
SGTC_1325 1431-0015 227 µM 0.64264109816171 0.230828143648614 no 798 0.260228504513456 1220 1103340
SGTC_3324 9138759 60.749 µM 0.642430273152701 0.23090129735234 no 799 0.260296924423188 1287 45595710
SGTC_2271 7849410 118.62 µM 0.64190337878456 0.231084179854897 no 800 0.26046796014468 1275 972430
SGTC_1568 digitonin 820 nM 0.641689359188374 0.231158488108975 no 801 0.260537449790318 1308 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_1798 st045719 60.953 µM 0.641188789456566 0.231332339491402 no 802 0.26070001615736 1218 3980186
SGTC_1602 st001878 87.6 µM 0.640714492265457 0.231497133499188 no 803 0.260854098333131 1302 595405 YLR310C CDC25
SGTC_1699 st031318 29.054 µM 0.640604770201287 0.231535265622311 no 804 0.260889749774028 1334 5340658
SGTC_286 k060-0067 22.9 µM 0.640433983751535 0.231594626647963 no 805 0.260945247545935 1245 5985051
SGTC_689 0833-0039 98 µM 0.638216836849452 0.232366019905542 no 806 0.261666269311345 1276 5374726
SGTC_1003 4049-0218 100 µM 0.635492041641601 0.233315989422762 no 807 0.262553777764253 1326 295161
SGTC_2287 7945887 168.79 µM 0.63505280341476 0.233469326391184 no 808 0.262696988591427 1310 1245853
SGTC_2333 9017922 200 µM 0.634710014161596 0.233589032087881 no 809 0.262808780602217 1332 3163164
SGTC_2524 avocatin b 10.57 µM 0.63449868536798 0.233662847332576 no 810 0.262877712243642 1231 6710748
SGTC_2752 diclazuril 33.15 µM 0.632973345077057 0.234196018322239 no 811 0.263375524766504 1329 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_3178 9107506 49.47 µM 0.631565425464417 0.234688743006964 no 812 0.263835442471473 1317 8897194
SGTC_2463 5473429 200 µM 0.631113967901666 0.234846859309504 no 813 0.263983004398531 1289 5399405
SGTC_2250 alverine citrate 130 µM 0.629099993642761 0.235552940576407 no 814 0.264641797319827 1235 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1065 prochlorperazine maleate 2.48 µM 0.628992665729693 0.235590601619796 no 815 0.264676928904718 1338 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_1196 1588-0294 184 µM 0.628617613550228 0.235722232387653 no 816 0.26479971314524 1289 6144269
SGTC_933 2914-0560 114 µM 0.628271825795864 0.235843628246445 no 817 0.264912942476364 1330 463887
SGTC_2522 biochanin a 4.94 µM 0.625930011247398 0.236666676525883 no 818 0.265680424381687 1270 5280373 A possible chelator.
SGTC_961 1252-1571 372 µM 0.623277170730394 0.237600942814499 no 819 0.266551198583561 1349 6813498
SGTC_1348 1493-0373 93.8 µM 0.622151733012859 0.237997905347451 no 820 0.266921050282428 1322 3010129
SGTC_2620 irigenin 100 µM 0.621550182248277 0.238210232341745 no 821 0.267118843687907 1369 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_152 4469-0003 551.229 µM 0.621531286155522 0.238216903701643 no 822 0.267125058032059 1296 697280
SGTC_393 acivicin 6.25 µM 0.621513528107166 0.238223173362582 no 823 0.267130898174909 1268 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2928 9011484 9.79 µM 0.621282005823081 0.238304922949366 no 824 0.267207045503776 1298 2994751
SGTC_863 0466-0191 129 µM 0.621166934753481 0.238345559796702 no 825 0.267244896279684 1307 765160 YPR165W RHO1
SGTC_2363 9053361 176 µM 0.620684068736331 0.238516123197666 no 826 0.267403756776635 1385 6469797 YMR079W SEC14
SGTC_184 1494-0393 24.714 µM 0.620574841529431 0.238554714932918 no 827 0.267439698584626 1288 3090647
SGTC_3186 9110464 49.47 µM 0.619919710322144 0.238786255075174 no 828 0.267655324200971 1322 17018021
SGTC_2875 9039966 71.43 µM 0.619135909567341 0.239063431778794 no 829 0.267913414351913 1408 6463691
SGTC_2971 9092186 9.93 µM 0.618250527946495 0.239376742109518 no 830 0.268205103758248 1244 25236400
SGTC_2536 dehydroabietamide 32.04 µM 0.617836279990154 0.239523409168017 no 831 0.268341632801173 1375 3983547
SGTC_2176 5809774 33.9695 µM 0.617480325888533 0.239649476107586 no 832 0.268458977103517 1303 2870539
SGTC_1382 3002-2117 298 µM 0.616587995707963 0.239965668489852 no 833 0.268753257219778 1362 1497314
SGTC_132 0417-1715 25.805 µM 0.615266877189974 0.240434217154349 no 834 0.269189244093634 1353 6769098
SGTC_2576 guaiol 23.12 µM 0.614273883413879 0.240786720659816 no 835 0.269517178801516 1311 227829
SGTC_2255 7941087 197.44 µM 0.612192818581086 0.2415263905858 no 836 0.270205096195168 1363 935561
SGTC_2960 9079389 5.97 µM 0.611883968793104 0.241636269685315 no 837 0.270307264449067 1343 16457355
SGTC_2516 gossypol 71.55 µM 0.611836785146204 0.241653058541243 no 838 0.270322874613602 1352 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2913 7966556 36.57 µM 0.611772172343098 0.241676050056011 no 839 0.270344251744227 1310 2976516
SGTC_2910 7948405 25.97 µM 0.611499436293178 0.241773112247857 no 840 0.270434495712702 1309 2971328
SGTC_1900 st060200 72.8 µM 0.6092758054547 0.242565254024003 no 841 0.271170820615524 1330 688945
SGTC_798 1287-0182 476 µM 0.607253263756427 0.24328697905427 no 842 0.271841424584994 1360 1649755
SGTC_3108 9121785 49.47 µM 0.604884282623959 0.244133801497224 no 843 0.272627943584875 1321 17140271
SGTC_1687 st020778 55.3625 µM 0.604024330204537 0.244441595196723 no 844 0.272913733221651 1343 4259299
SGTC_1854 st056233 32.9 µM 0.603849044959639 0.244504358838512 no 845 0.272972004325373 1305 5393174
SGTC_1115 galangin 695.678 nM 0.602758689014963 0.24489497284456 no 846 0.273334616231783 1372 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1642 st009582 77.7 µM 0.602478607014878 0.244995364860616 no 847 0.273427799601102 1370 6739311
SGTC_1186 1319-0216 26 µM 0.601431710581258 0.245370808234658 no 848 0.273776241577053 1405 4565136
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.60054741861987 0.245688178306583 no 849 0.27407073436062 1403 94937 An inhibitor of serotonin biosynthesis.
SGTC_1146 3579-1023 7 µM 0.600382870093954 0.245747258657614 no 850 0.27412555067122 1434 X1146
SGTC_604 1000-0114 314 µM 0.599701204260481 0.245992088701924 no 851 0.274352692765749 1398 1572745
SGTC_1492 4158-0558 28.5 µM 0.598719528376781 0.24634490146663 no 852 0.274679966230828 1396 3967268
SGTC_3260 9137109 49.47 µM 0.596988144370918 0.246967818613776 no 853 0.275257648004659 1260 17478346
SGTC_1596 piperlongumine 63 µM 0.596660041333182 0.247085958413025 no 854 0.275367187991968 1416 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_195 4234-0266 16.654 µM 0.596455187683641 0.247159735230197 no 855 0.275435590999365 1336 2303354
SGTC_3330 9141424 71.43 µM 0.595719123862546 0.2474249214049 no 856 0.275681440197443 1375 27261020
SGTC_1993 st073995 70.8 µM 0.594028306785353 0.248034657709781 no 857 0.276246590201574 1371 3098394
SGTC_1218 1348-1416 30.7 µM 0.593670187794122 0.248163904081881 no 858 0.27636636320437 1340 6787668
SGTC_2532 xanthone 78.9 µM 0.593342920500497 0.248282047374369 no 859 0.276475840118558 1345 7020 An insecticide.
SGTC_1690 st023502 41.2 µM 0.593255798470679 0.248313503427121 no 860 0.276504987619527 1368 24207482
SGTC_81 0411-0046 9.971 µM 0.592429985218447 0.248611774893366 no 861 0.276781346071532 1255 12925265
SGTC_2018 5133068 143 µM 0.591865418044971 0.248815797944635 no 862 0.276970356346941 1350 785362
SGTC_1152 3909-8331 15.9 µM 0.59019206834011 0.249421035626991 no 863 0.277530944558913 1332 16001939
SGTC_458 nppb 133 µM 0.588685553095473 0.249966599183403 no 864 0.27803611547871 1435 4549 A chloride channel blocker.
SGTC_1184 1269-1718 139 µM 0.588333600151449 0.250094145243455 no 865 0.278154198410271 1429 5403821
SGTC_144 4161-2749 112.381 µM 0.587931385129624 0.250239948301403 no 866 0.278289174597734 1281 797501 YMR168C CEP3
SGTC_2876 9059903 25.97 µM 0.587252902319497 0.250486000621063 no 867 0.278516933661967 1345 6916095
SGTC_2019 4016004 108 µM 0.585851991915206 0.250994447233577 no 868 0.278987490671463 1322 45595336
SGTC_1469 k284-2957 126 µM 0.58583593976312 0.251000276366892 no 869 0.278992884728601 1392 23884841
SGTC_2914 7968218 45.32 µM 0.585587484379879 0.2510905088896 no 870 0.27907638047134 1388 2977111
SGTC_117 lucigenin 22.078 µM 0.584928207189477 0.251330024346013 no 871 0.279297995584049 1313 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2303 7774051 200 µM 0.584659853739257 0.251427551753213 no 872 0.279388226705207 1417 2953184
SGTC_2096 5468907 200 µM 0.584036391233309 0.251654213258101 no 873 0.279597914287686 1381 759785
SGTC_1914 st062367 72.6 µM 0.583713967622832 0.251771473571407 no 874 0.279706384174417 1368 978205
SGTC_1276 0871-0068 94.2 µM 0.583575296128027 0.251821915048212 no 875 0.279753042376212 1388 3414906
SGTC_3126 9127922 49.47 µM 0.582730513689395 0.25212931817159 no 876 0.280037364239267 1378 45595682
SGTC_2438 5259590 200 µM 0.58204967034279 0.252377210392293 no 877 0.280266612285742 1383 1201127
SGTC_1786 berberine 21.6 µM 0.58045038423153 0.252960008723276 no 878 0.280805468206805 1329 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1299 1079-1439 3.74 µM 0.579491630223315 0.253309729004747 no 879 0.281128746257218 1327 323161
SGTC_1058 3448-5425 97.3 µM 0.57941204078941 0.253338771897548 no 880 0.281155590747491 1293 7279705
SGTC_1177 0983-0204 23.6 µM 0.578806451384267 0.253559814179306 no 881 0.281359888786737 1393 766818
SGTC_1072 oxiconazole 14.9 nM 0.577324066880902 0.254101317042839 no 882 0.281860279342526 1379 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_2394 5221648 200 µM 0.576275935057474 0.254484556731727 no 883 0.282214343084279 1498 788586
SGTC_1852 st056254 31.4 µM 0.574361753282994 0.255185240389747 no 884 0.28286151438236 1380 442583
SGTC_2724 maprotiline 69.64 µM 0.573089469894807 0.255651515497031 no 885 0.283292058324673 1384 4011 A tricyclic antidepressant.
SGTC_2877 9040724 71.43 µM 0.57285075957458 0.255739049229646 no 886 0.283372873507694 1438 6463895
SGTC_2139 5578692 56.4705 µM 0.572554843133587 0.255847581843045 no 887 0.28347307111764 1364 650991 YMR113W FOL3
SGTC_68 0986-0284 82.829 µM 0.572214550792029 0.25597241981802 no 888 0.283588315440254 1325 423278 YIL048W NEO1
SGTC_1034 k072-0165 12.7 µM 0.570791728902981 0.256494733298094 no 889 0.284070415128624 1429 5835461
SGTC_216 k038-0035 28.382 µM 0.570454959019419 0.256618441684395 no 890 0.284184581390371 1333 4444231 YPR107C YTH1
SGTC_1130 3454-2858 15.9 µM 0.570092080617434 0.256751775492813 no 891 0.284307623089691 1382 715628 YIL048W NEO1
SGTC_2647 atorvastatin 60.16 µM 0.569516502617807 0.256963336277145 no 892 0.284502837353626 1414 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_673 1082-0474 110 µM 0.56211114879606 0.25969333328011 no 893 0.287020146416298 1393 3098046
SGTC_2456 5770359 74.46 µM 0.561810034985401 0.259804655313707 no 894 0.287122727127243 1451 3118787
SGTC_1426 4048-4480 71.7 µM 0.56162770612869 0.259872074414709 no 895 0.287184849698095 1437 14224343
SGTC_896 0964-0007 44.5 µM 0.561403046558261 0.25995515840501 no 896 0.28726140381816 1378 6756758
SGTC_721 1187-1332 279 µM 0.559066968949712 0.260819901812864 no 897 0.288058008258666 1344 25730
SGTC_2871 9038510 12.99 µM 0.557874739149505 0.26126179792383 no 898 0.288464961052513 1505 4945164
SGTC_2478 5763493 32.33 µM 0.556302758055777 0.26184503500941 no 899 0.289001951016289 1413 1365576 YLR208W SEC13
SGTC_414 piperonyl butoxide 100 µM 0.555972933676207 0.261967491289067 no 900 0.289114678937847 1368 5794 A potent inhibitor of cytochrome P450.
SGTC_1804 st050076 49.1 µM 0.555605583434628 0.262103914621259 no 901 0.289240256845319 1421 3895976
SGTC_632 0781-2353 4.65 µM 0.555416455795566 0.262174165391621 no 902 0.289304919727479 1438 6811515 YHR007C ERG11
SGTC_2180 6301957 200 µM 0.555157965811821 0.262270196153211 no 903 0.289393308633761 1383 845462
SGTC_3345 9148410 3.559 µM 0.554935007908518 0.26235304097953 no 904 0.28946955777426 1417 4903596
SGTC_2526 patulin 37.61 µM 0.554913371270296 0.262361081253265 no 905 0.289476957767824 1449 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_3002 9075603 71.4286 µM 0.554800565696087 0.262403002364511 no 906 0.289515540086004 1371 20105405
SGTC_843 0310-0051 143 µM 0.553445173434362 0.262906964930467 no 907 0.289979306737715 1419 2065037
SGTC_1859 st055998 20 µM 0.550355173003459 0.264057737503281 no 908 0.291037894288077 1524 676301
SGTC_1345 1488-0192 31.4 µM 0.549710786058911 0.26429804197693 no 909 0.291258878819759 1413 658348
SGTC_1194 1488-0194 225 µM 0.548689254982141 0.264679218899931 no 910 0.291609360676653 1420 1391452
SGTC_3058 9093861 49.47 µM 0.546609835494704 0.265456002093537 no 911 0.292323405236848 1437 17217477
SGTC_2182 6325192 200 µM 0.546312035590088 0.265567342161071 no 912 0.292425732228597 1368 736248
SGTC_1936 st074407 74.3 µM 0.544685586893325 0.266175849033632 no 913 0.292984889689203 1420 809813
SGTC_1916 st067606 49.2 µM 0.543931108036133 0.266458363379898 no 914 0.293244440611855 1496 19590279
SGTC_2006 4011487 200 µM 0.54386291700218 0.266483904961202 no 915 0.293267904500263 1511 45595294
SGTC_1119 parthenolide 318.541 nM 0.543646617974867 0.266564929951979 no 916 0.29334233670279 1519 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1006 4099-6547 255 µM 0.5431176318312 0.266763139110187 no 917 0.293524406775855 1451 3146833
SGTC_2976 9009005 19.48 µM 0.543113724561496 0.266764603426816 no 918 0.293525751801381 1536 2993148
SGTC_2887 9044784 58.44 µM 0.541068864069186 0.267531507073316 no 919 0.294230059058215 1400 6465546
SGTC_2118 5526350 200 µM 0.539872156683351 0.267980834803956 no 920 0.29464260041419 1462 743594
SGTC_2525 harmine 47.85 µM 0.538362402760471 0.268548243696809 no 921 0.295163438714934 1481 5280953 A monoamine oxidase inhibitor
SGTC_2995 9067767 71.4286 µM 0.538135338209135 0.268633633289976 no 922 0.295241808611885 1436 11673567
SGTC_1814 st052110 31.539 µM 0.537959418159272 0.268699798928923 no 923 0.295302532891089 1473 674163
SGTC_2720 fluspirilene 36.88 µM 0.53668053526205 0.269181048096908 no 924 0.295744151784902 1444 3396 An atypical antipsychotic.
SGTC_2970 9090938 41.86 µM 0.536647889576556 0.269193338467175 no 925 0.295755428837655 1503 17217104
SGTC_1255 0566-0045 221 µM 0.535889726942451 0.269478848899453 no 926 0.296017382401775 1489 2788469
SGTC_1790 st045711 43.5 µM 0.535791104362878 0.269515999544478 no 927 0.29605146541888 1554 585119
SGTC_1327 1436-0082 2.18 µM 0.534856662856196 0.269868126429824 no 928 0.296374488778827 1401 15992205
SGTC_2479 5617353 43.85 µM 0.533371678248859 0.270428188650155 no 929 0.296888159332236 1497 2731746
SGTC_1791 st048313 56.1 µM 0.531336954476109 0.271196527141006 no 930 0.297592650739659 1477 1204976
SGTC_1007 4101-0031 70 µM 0.531083049023926 0.271292481508165 no 931 0.297680615069897 1516 1146276
SGTC_2093 5331342 194.4 µM 0.530522156658146 0.271504510417942 no 932 0.29787497558923 1479 33839
SGTC_3055 9094636 49.47 µM 0.526440712565473 0.273049861764313 no 933 0.299291017401492 1489 25236176
SGTC_567 1080-0542 68.4 µM 0.523672667191836 0.274100398230106 no 934 0.300253114789595 1445 5950415
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.52285411273233 0.274411440477692 no 935 0.300537889702579 1514 5024745
SGTC_3149 9097855 49.47 µM 0.520970631557463 0.275127804835778 no 936 0.301193615119445 1565 25236625 YMR079W SEC14
SGTC_2292 7671323 168.05 µM 0.520605537582232 0.275266771380953 no 937 0.301320795466548 1438 937504
SGTC_1165 k072-0275 30.3 µM 0.519965753988074 0.275510376949168 no 938 0.301543722131977 1452 6153523 YGL055W OLE1
SGTC_2709 st078560 56 µM 0.519612372544029 0.27564497677786 no 939 0.30166688642496 1563 17250903
SGTC_446 go6976 132 µM 0.519471070726634 0.275698806421907 no 940 0.30171614078131 1484 3501 A protein kinase C inhibitor.
SGTC_2049 5262831 67.185 µM 0.519105113468606 0.275838243712675 no 941 0.301843721333457 1466 763417
SGTC_1866 st057638 64 µM 0.517682652536938 0.276380559643234 no 942 0.302339851833599 1460 688802
SGTC_2670 beta-carotene 100 µM 0.517668338723448 0.276386019468456 no 943 0.302344846110099 1415 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_499 genistein 192 µM 0.517273987484509 0.276536460621219 no 944 0.302482454960236 1526 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_3096 9117468 49.47 µM 0.516266110765228 0.276921138082082 no 945 0.302834281029753 1389 41316311
SGTC_1520 flindersine 88 µM 0.515438059599992 0.27723737725465 no 946 0.303123471259264 1604 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1482 3346-2049 8.48 µM 0.51472790541474 0.277508731294491 no 947 0.303371585259944 1492 3826804
SGTC_164 4100-3994 89.624 µM 0.514357584988055 0.277650284354721 no 948 0.303501003973979 1563 4615967
SGTC_1294 1000-1494 117 µM 0.5137523054061 0.27788172524475 no 949 0.303712588735616 1422 712797 YDL207W GLE1
SGTC_487 nimodipine 119 µM 0.51261017983748 0.27831869638998 no 950 0.304112015436824 1466 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2327 6189656 200 µM 0.512477507060349 0.278369477992145 no 951 0.304158429228286 1582 5349088
SGTC_2212 7123476 200 µM 0.512241415362352 0.278459855207411 no 952 0.304241030546279 1480 1085715
SGTC_569 4130-2812 160 µM 0.511568139319044 0.278717667512632 no 953 0.304476644250224 1443 743552
SGTC_2820 7989630 71.43 µM 0.510070964110242 0.279291385215459 no 954 0.305000873195875 1430 2984098
SGTC_539 4859-0462 2.54 µM 0.508967590566219 0.279714565041014 no 955 0.305387470698156 1547 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1548 st061468 90.8 µM 0.50782351993231 0.280153681838317 no 956 0.305788556878991 1478 390799
SGTC_1832 st054113 55 µM 0.506720052036062 0.280577530719575 no 957 0.306175629462333 1480 1251267
SGTC_415 dibenzyl ketone 100 µM 0.505711928192469 0.28096502839222 no 958 0.306529446671953 1584 7593
SGTC_114 0364-0001 490.298 µM 0.505681511696786 0.28097672375306 no 959 0.306540124633649 1413 4003655
SGTC_1235 benzylparaben 21.5 µM 0.505551074397189 0.281026880498225 no 960 0.306585917585832 1452 7180
SGTC_921 1561-0023 372 µM 0.505488575285003 0.281050914666399 no 961 0.306607860377146 1440 24050882
SGTC_1121 fusaric acid 630.51 nM 0.505463961465071 0.281060380236412 no 962 0.306616502224801 1448 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_1726 st035556 14.5795 µM 0.505112177552154 0.281195680221104 no 963 0.306740024381901 1568 5919439
SGTC_939 1165-0479 45.3 µM 0.503760650283281 0.281715784910281 no 964 0.307214791261832 1447 1377347
SGTC_2082 5219693 150 µM 0.502343292707091 0.282261720612224 no 965 0.307713030478508 1457 2834649
SGTC_1432 4049-0298 68.4 µM 0.501427363620715 0.28261478742122 no 966 0.308035192935905 1555 741646
SGTC_1250 0485-0349 40.2 µM 0.501399348931734 0.282625589699006 no 967 0.308045048959186 1474 6842794 YDL195W SEC31
SGTC_1888 azatryptophan 97.5 µM 0.501004827871254 0.282777735468834 no 968 0.308183862586026 1453 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_998 3996-0085 177 µM 0.499537814676239 0.283343829279417 no 969 0.308700276950309 1594 715391
SGTC_324 1315-0088 19.6 µM 0.498004887698986 0.283935937977288 no 970 0.309240298587005 1494 6787421
SGTC_2953 9074162 66.49 µM 0.497302309875111 0.284207513583143 no 971 0.309487941557927 1603 16451992
SGTC_2948 9070189 9.45 µM 0.495426669416461 0.284933134505778 no 972 0.310149486526576 1551 6473636 YDL196W YDL196W
SGTC_2207 7258803 200 µM 0.49539948392335 0.28494365813336 no 973 0.310159079471246 1513 3666799
SGTC_895 0964-0006 13.7 µM 0.49501438130887 0.285092753009929 no 974 0.310294984502059 1465 6738897
SGTC_2997 9067075 71.4286 µM 0.495002751993433 0.285097255950281 no 975 0.31029908896059 1545 27209819
SGTC_608 k048-0125 159 µM 0.493629588682537 0.285629191186932 no 976 0.31078390014884 1527 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_980 1473-0395 201 µM 0.493551768851093 0.285659351125248 no 977 0.310811385189732 1453 768876
SGTC_1597 7-benzyloxygramine 47.5 µM 0.492776489158674 0.285959902077252 no 978 0.311085262402254 1467 260807
SGTC_2778 tioconazole 65.09 nM 0.492713771756805 0.285984222162779 no 979 0.311107422683109 1446 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1748 st037455 53.6035 µM 0.491228052994757 0.286560630362412 no 980 0.311632579888578 1535 580690
SGTC_1815 st051655 58.2 µM 0.490974275477059 0.286659142462041 no 981 0.31172232102434 1508 5984156
SGTC_1428 4049-0204 61.7 µM 0.490630305894409 0.286792691210594 no 982 0.311843973844279 1572 X1428
SGTC_732 3970-1727 52.7 µM 0.487467455367674 0.28802207162366 no 983 0.312963550280966 1620 1275699
SGTC_846 0335-0850 148 µM 0.486614065965892 0.288354204426059 no 984 0.313265926815615 1494 6819598
SGTC_386 1509-0011 3.07 µM 0.486096739726228 0.288555631820282 no 985 0.31344928918754 1497 3107280
SGTC_1555 citronellol 128 µM 0.485785138052735 0.288676989783315 no 986 0.313559756299826 1578 8842 A terpine precursor.
SGTC_3060 1327-0027 12.5 µM 0.482677976761779 0.289888433415139 no 987 0.314662201475078 1530 16000455 YPR107C YTH1
SGTC_3185 9108267 49.47 µM 0.482357994760307 0.290013325722769 no 988 0.314775827708659 1448 4910486
SGTC_1998 st075797 76.8 µM 0.481833783441845 0.290217985355088 no 989 0.314962014070484 1518 24208315
SGTC_1457 k015-0032 57.3 µM 0.48131252682167 0.290421558494852 no 990 0.315147197636125 1503 4302660
SGTC_345 1362-0200 395 µM 0.481311754141986 0.29042186030913 no 991 0.315147472175684 1459 1419823
SGTC_1787 fluconazole 80 µM 0.480136185473342 0.290881215899591 no 992 0.315565279733186 1450 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_3027 9089541 49.47 µM 0.479715004173971 0.291045875847252 no 993 0.315715028732357 1489 9943819
SGTC_1861 st057647 17.4 µM 0.479582077572578 0.291097852261868 no 994 0.315762296433517 1620 688668
SGTC_1704 st028805 70.8 µM 0.479332478253013 0.291195461275495 no 995 0.315851060218009 1494 2876101
SGTC_2099 5377090 177.372 µM 0.478938705665009 0.291349482156771 no 996 0.315991117228698 1484 2243829
SGTC_1979 st071809 45.3 µM 0.478711873472205 0.291438222940549 no 997 0.316071808882027 1575 4976333
SGTC_1056 3448-1962 115 µM 0.478628828818372 0.291470714637375 no 998 0.316101352781507 1545 715507
SGTC_1889 st059080 5.18 µM 0.477538337314585 0.291897532374058 no 999 0.316489414062117 1629 176925 Isolated from Daphnopsis sellowiana.
SGTC_3111 9122088 49.47 µM 0.476849358992973 0.292167348059084 no 1000 0.316734697461477 1536 16876704
SGTC_1101 ebselen 5.29 µM 0.475765835821358 0.292591908854836 no 1001 0.317120605914091 1631 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1176 0848-0131 83.3 µM 0.475121367854942 0.29284456894066 no 1002 0.317350234523536 1610 6769040
SGTC_2147 5545932 89.7195 µM 0.474746531489401 0.292991568024546 no 1003 0.317483823788548 1523 797404
SGTC_2881 9058953 51.95 µM 0.474450360055084 0.293107741393107 no 1004 0.317589394193754 1442 17122249
SGTC_683 panaxydol 45 µM 0.473948129417013 0.293304790384612 no 1005 0.317768448375143 1569 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_102 gallobenzophenone 83.616 µM 0.473557441406324 0.293458118336101 no 1006 0.317907765098427 1600 70837
SGTC_588 3970-1144 52.9 µM 0.472630946405748 0.293821875432959 no 1007 0.318238250018474 1556 1888707
SGTC_470 aa-861 153 µM 0.47249069526393 0.293876958499396 no 1008 0.318288290849222 1485 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2981 9013952 38.96 µM 0.47141333751166 0.294300245556352 no 1009 0.318672796649134 1416 2996344
SGTC_2267 7931562 200 µM 0.469551673225569 0.29503234459351 no 1010 0.319337679329456 1427 934880
SGTC_2046 4110841 106 µM 0.46889648230449 0.295290197696437 no 1011 0.319571815415592 1544 44119630 YMR134W ERG29
SGTC_151 3013-0144 2.285 µM 0.468330615899093 0.295512980199769 no 1012 0.319774088794761 1598 906558 YHR107C CDC12
SGTC_189 3970-0742 2.116 µM 0.468260442780268 0.295540612854189 no 1013 0.319799176463252 1559 2891807
SGTC_751 0833-0568 350 µM 0.467742596285611 0.295744566312632 no 1014 0.31998433781247 1574 6954252
SGTC_3327 9140648 26.9345 µM 0.465639132138421 0.296573678191914 no 1015 0.32073691382116 1601 8029710
SGTC_532 1548-0774 215 µM 0.463285919085608 0.297502492267748 no 1016 0.321579718721945 1641 5932993
SGTC_1375 2910-0797 186 µM 0.463125930164777 0.297565688146128 no 1017 0.321637052283554 1568 742508
SGTC_3142 9086498 49.47 µM 0.463067431469658 0.297588796753672 no 1018 0.321658016911774 1520 25236367
SGTC_2591 skatole 100 µM 0.463006584281873 0.297612833950064 no 1019 0.321679823789983 1543 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_3104 9120930 49.47 µM 0.461183216324478 0.298333551683007 no 1020 0.322333581040126 1536 17014836
SGTC_2682 pyrogallin 40.03 µM 0.460814419166858 0.298479421687529 no 1021 0.322465877894172 1551 822798 An ATP competetive kinase inhibitor.
SGTC_1285 0929-0069 65.5 µM 0.460101584112321 0.298761460626608 no 1022 0.322721653550569 1552 1206237
SGTC_41 0478-0632 82.643 µM 0.459714639054574 0.298914609264774 no 1023 0.322860530243697 1610 3750424
SGTC_2844 9010103 25.97 µM 0.459557140298179 0.298976955767017 no 1024 0.322917064482594 1530 2480525
SGTC_1672 st016598 6.51 µM 0.459259181157687 0.299094920216805 no 1025 0.323024028222694 1493 4665860 YNL267W PIK1
SGTC_564 3555-0129 330 µM 0.459243792771934 0.299101013177786 no 1026 0.323029552865284 1510 563260
SGTC_2208 7283366 200 µM 0.458198584241423 0.299514990530351 no 1027 0.323404888466257 1625 898663
SGTC_513 4245-1575 41.7 µM 0.456374764445932 0.300237974899864 no 1028 0.324060254674096 1633 719745
SGTC_2909 7941780 10.49 µM 0.45568328448702 0.300512292088783 no 1029 0.324308871879053 1627 1243215
SGTC_2946 9065502 71.43 µM 0.454568807537442 0.300954654581722 no 1030 0.32470973981537 1471 16489101
SGTC_2624 nerol 100 µM 0.45338562005245 0.301424610968392 no 1031 0.325135544646861 1634 637566 A natural product oil.
SGTC_3213 9129884 49.47 µM 0.453337961865428 0.301443547490069 no 1032 0.325152700637844 1432 17190742
SGTC_426 0988-0037 14.6 µM 0.452707487379713 0.301694110832784 no 1033 0.325379693675742 1580 5383008
SGTC_2262 9014885 67.46 µM 0.452494325732772 0.301778846772039 no 1034 0.325456454043236 1574 6457424
SGTC_2188 6126565 140.678 µM 0.452489344761789 0.301780826933696 no 1035 0.325458247799486 1588 874518
SGTC_700 3453-2283 142 µM 0.451977424760477 0.301984369467457 no 1036 0.325642622906288 1628 565664
SGTC_210 3551-0445 56.827 µM 0.451321671472459 0.302245191045233 no 1037 0.325878863896326 1577 2865180 YOR207C RET1
SGTC_2551 apiole 73.87 µM 0.451076767059274 0.302342626092329 no 1038 0.325967110841641 1534 10659 A possible DNA adduct former.
SGTC_2447 5741742 33.78 µM 0.450594344681988 0.302534598694305 no 1039 0.326140971669903 1622 1776504
SGTC_2507 purpurin 79.67 µM 0.449843920306358 0.302833327138688 no 1040 0.326411493201708 1470 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_786 4544-0069 423 µM 0.447851106534396 0.303627265439463 no 1041 0.327130328430516 1612 748821 YLR208W SEC13
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.447386729368089 0.303812407019795 no 1042 0.327297927928414 1538 3256 An antibiotic and ribosome inhibitor.
SGTC_8 0354-0001 70 µM 0.446645059761589 0.304108206158324 no 1043 0.327565677929452 1583 4993152
SGTC_2735 sertaconazole 140 nM 0.446095306935019 0.304327546160274 no 1044 0.327764201345351 1626 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_234 nsc-17383 10.7 µM 0.445283739566418 0.304651473426601 no 1045 0.328057358629255 1638 408974
SGTC_1391 3442-0225 151 µM 0.445271765069407 0.3046562540495 no 1046 0.328061684893755 1560 5227075
SGTC_1666 st014829 29 µM 0.445269029102021 0.304657346344599 no 1047 0.328062673374301 1531 3858230
SGTC_553 k007-0256 45.7 µM 0.444492987230838 0.30496724002667 no 1048 0.328343098951377 1577 6287000
SGTC_3009 9080819 71.4286 µM 0.444048376933802 0.305144847535441 no 1049 0.328503804114663 1547 17027216
SGTC_2965 9082772 38.63 µM 0.443732061281312 0.305271233407161 no 1050 0.328618156275323 1703 16459634
SGTC_1048 3161-0300 24.5 µM 0.443451042585945 0.305383535640214 no 1051 0.328719761598816 1514 2165101
SGTC_423 5-fluorouracil 457 µM 0.44334477627145 0.305426007141664 no 1052 0.32875818662449 1471 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_52 0329-0193 875 nM 0.442515662299669 0.305757469358946 no 1053 0.32905804955769 1636 3739292
SGTC_3061 glucosamine 200 µM 0.440913244599548 0.306398533047406 no 1054 0.329637902417738 1635 91431 and experimental redox chemotherapeutic
SGTC_1510 1123-0200 71.5 µM 0.438953366054738 0.307183408790703 no 1055 0.330347663539022 1684 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2808 7946468 45.46 µM 0.438517618380318 0.307358033636475 no 1056 0.33050555066604 1607 2970879
SGTC_733 4069-0007 56.1 µM 0.437925428208581 0.307595422456418 no 1057 0.330720170923604 1611 5717425 YNL287W SEC21
SGTC_814 3342-0569 96 µM 0.437654182785571 0.307704182402613 no 1058 0.330818493683797 1590 4346283
SGTC_2078 5212016 200 µM 0.434721215900895 0.308881277541797 no 1059 0.33188239838606 1651 1899708
SGTC_1446 4239-0190 62 µM 0.433589930780066 0.309335825113398 no 1060 0.332293124019549 1550 1340085
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.433135038681126 0.309518681970159 no 1061 0.3324583344808 1634 5377381
SGTC_3033 9090887 49.47 µM 0.432914900888508 0.309607189574979 no 1062 0.332538297145405 1528 19325384
SGTC_1796 st049173 110.4 µM 0.432762986513378 0.309668274020883 no 1063 0.332593482838191 1616 94134
SGTC_670 4204-0025 119 µM 0.432518159842019 0.309766729365641 no 1064 0.332682428267542 1645 719039
SGTC_3259 9138485 49.47 µM 0.432026828208474 0.309964356142514 no 1065 0.332860957263184 1667 17646153
SGTC_3165 9101544 49.47 µM 0.431123875035749 0.310327691337172 no 1066 0.333189150801993 1617 5002184
SGTC_3151 9099821 49.47 µM 0.43087523968793 0.310427771109323 no 1067 0.333279543953962 1532 17174189
SGTC_1556 plumbagin 1.48 µM 0.430797747434179 0.310458965871469 no 1068 0.333307718794614 1557 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2920 7982904 15.77 µM 0.430748720909249 0.310478702364768 no 1069 0.333325544475319 1545 6456808
SGTC_535 2293-4129 48.2 µM 0.430680325672749 0.310506236986459 no 1070 0.333350413104745 1685 396118 YIL048W NEO1
SGTC_598 3937-0236 20.2 µM 0.430051849833642 0.310759299097469 no 1071 0.333578962316021 1625 1379313
SGTC_3243 9134147 49.47 µM 0.428999128459616 0.311183388523669 no 1072 0.333961929472154 1632 24282180
SGTC_1035 k081-0041 55.2 µM 0.427577394213185 0.311756533004318 no 1073 0.334479413513322 1653 731709
SGTC_686 1319-0111 510 µM 0.427260505230549 0.311884342856339 no 1074 0.334594797950379 1687 4562600
SGTC_1546 5-methoxyflavanone 78.7 µM 0.427145166050167 0.311930867875397 no 1075 0.334636798702132 1665 147795
SGTC_1372 2752-0194 270 µM 0.426981089557117 0.311997057511243 no 1076 0.334696550707233 1527 823334
SGTC_1691 st019933 84.6 µM 0.426066943500623 0.312365941685211 no 1077 0.335029533371008 1664 6176082
SGTC_2950 9072895 21.46 µM 0.424150072734952 0.313140064598905 no 1078 0.335728184868839 1522 17332245
SGTC_2770 toltrazuril 17.5 µM 0.423084027894766 0.313570940769704 no 1079 0.336116977606317 1658 68591 Kills coccidiodes.
SGTC_3197 9113331 49.47 µM 0.422994983580512 0.313606942405559 no 1080 0.336149460526346 1703 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_356 1634-0012 32.5 µM 0.422413572028621 0.313842057382962 no 1081 0.336361586615707 1695 735457
SGTC_1287 0971-0001 34.6 µM 0.422331423116234 0.313875283391759 no 1082 0.33639156257814 1615 4665869
SGTC_842 0271-0008 11.1 µM 0.421328403871228 0.31428108693193 no 1083 0.336757645975688 1650 1221709
SGTC_1330 1469-0054 61.8 µM 0.420680211211567 0.314543453515168 no 1084 0.336994306589444 1742 7102664
SGTC_2237 6667747 47.222 µM 0.420098517885593 0.314778983171437 no 1085 0.337206742686588 1577 729940 YDL015C TSC13
SGTC_2175 5807670 165.306 µM 0.416743783117853 0.316138795280446 no 1086 0.338432912897046 1622 241186
SGTC_58 0957-0393 9 µM 0.416710161441108 0.316152436166312 no 1087 0.338445210468279 1569 6997992
SGTC_5 0352-0601 109.883 µM 0.416403319944075 0.316276938539742 no 1088 0.338557449748442 1617 762456
SGTC_857 0438-0306 1.35 µM 0.416016455815585 0.316433940157343 no 1089 0.338698980874986 1609 4686136
SGTC_3017 9080681 49.47 µM 0.415566983450573 0.316616391718166 no 1090 0.338863445327942 1577 16451914
SGTC_2593 nobiletin 86.24 µM 0.414688488771662 0.316973122499662 no 1091 0.339184980125271 1568 72344 An anti-infammatory.
SGTC_1493 4348-0038 111 µM 0.413813453161651 0.317328617862372 no 1092 0.339505365346965 1656 800424
SGTC_612 0302-0167 22.4 µM 0.413270266815484 0.317549379686617 no 1093 0.339704305782625 1694 235821
SGTC_2698 st077697 67.5 µM 0.412452413939536 0.31788189390394 no 1094 0.340003926279266 1544 3154499
SGTC_1178 0988-0033 191 µM 0.411454017839928 0.318288010643863 no 1095 0.340369825812821 1651 5392207
SGTC_205 1486-1330 71.903 µM 0.407604338610937 0.31985598353004 no 1096 0.341782089270793 1645 4118834
SGTC_2374 9071832 200 µM 0.403997595788615 0.321327935457722 no 1097 0.343107243565259 1591 17381698
SGTC_889 0919-1524 82.7 µM 0.403392019348761 0.321575354153323 no 1098 0.343329928406245 1588 3905452
SGTC_380 3970-0968 6 µM 0.402679078654531 0.321866739828604 no 1099 0.343592163357214 1590 2891601
SGTC_453 enantio-paf c16 10 µM 0.402511696652245 0.321935166341745 no 1100 0.343653740982691 1602 13871343 A lipid and platelet activating factor
SGTC_1976 st070609 63.5 µM 0.402023771801196 0.32213466665686 no 1101 0.34383326575285 1593 682556
SGTC_1886 st057356 49.9 µM 0.401587345857673 0.322313153783416 no 1102 0.343993872097674 1556 24207747
SGTC_1837 st055472 66.5 µM 0.399983057913717 0.322969618700004 no 1103 0.344584497675309 1683 676091
SGTC_906 1165-0455 526 µM 0.399722056818315 0.323076471018294 no 1104 0.344680622253036 1581 3252859
SGTC_2276 7947513 42.08 µM 0.3992521741257 0.32326887503993 no 1105 0.344853701498298 1484 2105100
SGTC_1926 methyl fluorone black 53.6 µM 0.398974395183404 0.323382640107412 no 1106 0.344956035437851 1545 72721 Reacts with homocysteine.
SGTC_97 0535-0701 19.132 µM 0.398824456905355 0.323444054571684 no 1107 0.345011277508902 1550 2832013 YGL099W LSG1
SGTC_3237 9133362 49.47 µM 0.398106685720992 0.323738119038922 no 1108 0.345275773177804 1687 43845137
SGTC_581 0958-0271 211 µM 0.39800976288577 0.323777835901465 no 1109 0.345311494631074 1575 4591145
SGTC_1927 st060202 13.8 µM 0.397369000084289 0.324040456984204 no 1110 0.345547686002965 1732 688887
SGTC_2270 7924575 90.91 µM 0.395434815171741 0.324833726955047 no 1111 0.34626100975114 1785 1262135
SGTC_2048 5246248 200 µM 0.394467291709816 0.325230837252781 no 1112 0.346618035512993 1723 677046
SGTC_1784 st039334 36.3 µM 0.394088002180734 0.32538656703756 no 1113 0.346758034316012 1740 3496984
SGTC_619 1652-1634 108 µM 0.392888552473068 0.325879241130875 no 1114 0.347200898463228 1621 5400454
SGTC_2214 7179297 48.276 µM 0.392215277104281 0.326155922417389 no 1115 0.347449578570304 1690 769744
SGTC_1843 st055809 45.5 µM 0.391656874416143 0.326385469610452 no 1116 0.34765587928357 1632 16413835
SGTC_443 clozapine 122 µM 0.390507528179762 0.32685814776562 no 1117 0.348080644823391 1726 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_3144 9087057 49.47 µM 0.39006995439855 0.327038176707098 no 1118 0.348242409739081 1796 17249618
SGTC_1776 st049249 45.9 µM 0.388399158574483 0.327725954470291 no 1119 0.348860333404679 1588 1822314
SGTC_1961 st076550 68.7 µM 0.388250735815432 0.32778708054394 no 1120 0.348915245191165 1658 1579337
SGTC_271 rotenone 740 µM 0.387179624947641 0.328228341009161 no 1121 0.349311616523077 1701 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1489 4065-0444 182 µM 0.386286091384354 0.32859662928068 no 1122 0.34964240005669 1761 2877968
SGTC_2391 6285546 200 µM 0.385161591381729 0.329060351817474 no 1123 0.35005884895243 1612 846083
SGTC_2024 5144227 134 µM 0.384768261132401 0.329222615939544 no 1124 0.350204558035498 1712 3475211
SGTC_1114 scopoletin 1.73284 µM 0.384519580953195 0.32932522285061 no 1125 0.350296692920223 1766 5280460 A coumarin with genotoxic properties.
SGTC_3287 9117173 37.0625 µM 0.38197213789479 0.330377052062928 no 1126 0.351241015623696 1653 2789709
SGTC_116 0155-0182 31.788 µM 0.37967194226254 0.33132794678316 no 1127 0.352094475065293 1647 771486
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.379609774297618 0.331353661987461 no 1128 0.352117552094351 1669 97141
SGTC_395 anisomycin 6.25 µM 0.379334870299235 0.3314673830174 no 1129 0.352219604226512 1643 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_449 xestospongin c 11.1929 µM 0.37795552784134 0.332038217513259 no 1130 0.352731815657173 1714 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_180 1486-1293 102.781 µM 0.377928157832823 0.332049548415323 no 1131 0.352741982068536 1836 4140536
SGTC_279 1273-0055 2.93 µM 0.37725699076193 0.332327452716692 no 1132 0.352991315596152 1771 2847562
SGTC_2855 9016525 58.44 µM 0.376936629652558 0.332460134372027 no 1133 0.353110349610525 1631 43811474
SGTC_2204 7233102 200 µM 0.374557012602424 0.333446339470174 no 1134 0.353994974125212 1711 2172480
SGTC_1762 st045503 25.4615 µM 0.374550711342978 0.333448952487757 no 1135 0.353997317672448 1651 4645554
SGTC_536 3852-0578 10.6 µM 0.37236466003851 0.334355955122912 no 1136 0.354810681166656 1770 2869208
SGTC_2306 7482397 179.52 µM 0.371623472476119 0.334663697195548 no 1137 0.355086605139844 1784 891448
SGTC_3024 9090631 49.47 µM 0.370563661310286 0.335103925183003 no 1138 0.355481276032532 1803 25236383
SGTC_2973 9094665 17.96 µM 0.370535757234283 0.335115519137932 no 1139 0.355491669533404 1781 25237061 YIL048W NEO1
SGTC_3063 1327-0034 4 µM 0.36790427545697 0.336209586654698 no 1140 0.356472306069366 1699 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2569 tetrandrine 100 µM 0.366594212350915 0.336754778218341 no 1141 0.356960862991465 1609 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1389 3405-0187 19 µM 0.365680076248908 0.337135405492605 no 1142 0.35730190740061 1628 799890
SGTC_3231 9132313 49.47 µM 0.365653097476398 0.337146641428437 no 1143 0.357311974330605 1701 4905967
SGTC_3233 9132340 49.47 µM 0.365548252952674 0.33719030774237 no 1144 0.357351097234228 1609 17682950
SGTC_2465 5809242 33.21 µM 0.364646442566965 0.337565989987385 no 1145 0.357687671115607 1741 2731748
SGTC_1610 st001799 48.1 µM 0.363724751825323 0.337950121472685 no 1146 0.358031779131429 1616 621897
SGTC_899 1083-0020 478 µM 0.363413102071261 0.338080045422102 no 1147 0.358148157915945 1789 767123
SGTC_1311 1190-0148 100 µM 0.363169890996864 0.338181451308594 no 1148 0.358238988930216 1785 1961333
SGTC_1050 3232-1156 69.3 µM 0.363012986251507 0.338246878346538 no 1149 0.358297591741717 1654 700529
SGTC_2381 9035592 200 µM 0.362369204126902 0.338515377417065 no 1150 0.358538074738972 1616 4749657
SGTC_2429 5902844 64.44 µM 0.361969468942553 0.338682134349994 no 1151 0.358687422930492 1813 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2639 lactacystin 53 µM 0.360798454135135 0.339170826798102 no 1152 0.359125059248777 1772 3870 A proteasome inhibitor.
SGTC_1411 3909-8223 150 µM 0.360510792020747 0.339290916515902 no 1153 0.3592325937957 1786 X1411
SGTC_1972 st070201 17.4 µM 0.359821201089331 0.339578865096325 no 1154 0.359490423742269 1792 2829099
SGTC_1279 0874-0590 65.2 µM 0.359351411393549 0.339775086172255 no 1155 0.359666109238228 1718 3523074
SGTC_2187 6125751 200 µM 0.357815725621282 0.340416811923051 no 1156 0.36024061068224 1709 874498
SGTC_2041 5107442 45.335 µM 0.356999865923935 0.34075792804842 no 1157 0.360545953053884 1788 793005
SGTC_2179 6298986 200 µM 0.356493223940964 0.340969823862547 no 1158 0.360735612867924 1815 738374
SGTC_2252 omeprazole 400 µM 0.355782635650269 0.341267101849085 no 1159 0.361001677043515 1764 4594 A proton pump inhibitor.
SGTC_894 0960-0238 55.9 µM 0.355646175997757 0.34132420167667 no 1160 0.361052779066327 1736 6741907 YDL195W SEC31
SGTC_1359 1582-0056 520 nM 0.355088540053879 0.341557575176592 no 1161 0.361261630842414 1739 3661189
SGTC_3081 9117243 49.47 µM 0.354483510734021 0.341810851574701 no 1162 0.361488279671452 1812 45595589
SGTC_1883 5-benzylidenerhodanine 20 µM 0.354163560920566 0.341944817246611 no 1163 0.361608155090582 1809 1273210
SGTC_2361 9034121 116 µM 0.353568919794538 0.34219385133321 no 1164 0.361830985028417 1688 6496917
SGTC_1569 carminic acid 40.6 µM 0.353099944159168 0.342390305480951 no 1165 0.362006757373743 1818 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1093 fluphenazine 7.97 µM 0.351513297020226 0.343055268818355 no 1166 0.362601649297652 1731 6602611 An atypical antipsychotic.
SGTC_45 0kpi-0036 14.9 µM 0.350808352287905 0.343350867114991 no 1167 0.362866065369469 1716 2795021
SGTC_1628 st004252 77.7 µM 0.350030098425054 0.343677316808942 no 1168 0.363158054740412 1806 692968
SGTC_1140 3229-1848 2.98 µM 0.350013100837369 0.343684447991852 no 1169 0.363164432872893 1802 2849525
SGTC_2031 5180455 200 µM 0.349462796622548 0.343915353146946 no 1170 0.363370948148283 1689 29949
SGTC_411 enrofloxacin 100 µM 0.349153830155286 0.344045019605056 no 1171 0.363486912875044 1859 71188 A bacterial gyrase inhibitor.
SGTC_1360 1598-0022 39.8 µM 0.347781974462359 0.344620978718724 no 1172 0.364001963955503 1789 761525
SGTC_2471 5466956 24.79 µM 0.347503809059164 0.344737807510661 no 1173 0.364106428694245 1747 724419
SGTC_945 3381-0768 11.3 µM 0.345343723317206 0.345645541485836 no 1174 0.364917989876435 1778 1126236 YIL048W NEO1
SGTC_2376 9072922 81.32 µM 0.34401405120734 0.346204752315519 no 1175 0.36541785948978 1735 17087968
SGTC_237 nikkomycin 200 µM 0.34345803808337 0.346438690385136 no 1176 0.365626951860496 1798 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2944 9067346 25.62 µM 0.343315596440952 0.346498630996185 no 1177 0.365680524399343 1748 6473075
SGTC_1607 st000305 50.6 µM 0.343108993368495 0.346585578093735 no 1178 0.365758232814419 1768 5457690
SGTC_283 0987-0079 11.7 µM 0.34148950120034 0.347267406893638 no 1179 0.366367553609179 1806 411556
SGTC_2747 doxorubicin 7.63 µM 0.341467773506673 0.347276557923089 no 1180 0.366375730772348 1805 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3224 9130643 49.47 µM 0.340921193283008 0.34750678980888 no 1181 0.36658145482288 1776 17644395
SGTC_725 1497-0963 19 µM 0.33986966137377 0.34794987689042 no 1182 0.366977342387681 1861 3549977
SGTC_472 calcifediol 10 µM 0.339329597408701 0.348177525996594 no 1183 0.367180724205482 1740 5283731 A vitamin D metabolite.
SGTC_371 0195-0006 7.36 µM 0.338897684974564 0.348359626182908 no 1184 0.367343404240784 1628 3928593
SGTC_1746 st038117 42 µM 0.33391388126852 0.350463385507639 no 1185 0.369222272337706 1721 2898218
SGTC_3320 9137005 35.139 µM 0.333908673132656 0.350465586376439 no 1186 0.369224237421895 1720 4908713
SGTC_804 1595-0054 20.9 µM 0.331477635343641 0.351493448149561 no 1187 0.370141865715043 1715 761523 Stimulates phospholipase C.
SGTC_1018 4259-0013 28.1 µM 0.330774912335096 0.351790767753497 no 1188 0.370407256113757 1742 6801262
SGTC_1313 1220-0047 237 µM 0.330700560106265 0.351822231223808 no 1189 0.370435339590623 1782 3528706
SGTC_351 caspofungin 25 nM 0.326870792998867 0.353444233345428 no 1190 0.371882806261721 1797 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3038 9091290 49.47 µM 0.325906867312549 0.353852900954705 no 1191 0.372247409885313 1819 25236843
SGTC_1659 st012954 42.1 µM 0.325744788653659 0.35392163266036 no 1192 0.372308727183786 1787 24207262
SGTC_2812 7970281 58.44 µM 0.324809974719863 0.354318146340396 no 1193 0.372662447401398 1840 2233435
SGTC_878 0828-0289 13.7 µM 0.324782559101842 0.354329777423426 no 1194 0.372672822701706 1724 745350 YLR208W SEC13
SGTC_1865 st057639 52.2 µM 0.322456832208468 0.3553169613236 no 1195 0.373553317766385 1763 688818
SGTC_2469 5655019 90.81 µM 0.321705055205437 0.355636270611455 no 1196 0.373838073893605 1857 2788239
SGTC_3308 9128332 17.569 µM 0.321629443409001 0.355668391530094 no 1197 0.373866717746614 1873 17332805 YDL196W YDL196W
SGTC_935 2996-0153 430 µM 0.320017464604088 0.356353425541564 no 1198 0.374477545677101 1900 23738523
SGTC_2799 7812892 81.82 µM 0.319755804618723 0.356464665594741 no 1199 0.374576726396042 1853 20205235
SGTC_1097 itavastatin 7.23 µM 0.319510306774759 0.356569045707857 no 1200 0.374669788493448 1777 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_3069 9117009 49.47 µM 0.319099418642519 0.35674377005387 no 1201 0.374825562246861 1829 41904981
SGTC_1853 st056710 91.2 µM 0.317428484796483 0.35745462030891 no 1202 0.375459248098272 1897 269167
SGTC_3337 9144342 33.5465 µM 0.317028352138053 0.35762491865552 no 1203 0.375611044576445 1823 17682949
SGTC_1742 st038235 28.8875 µM 0.316413358636795 0.357886718051817 no 1204 0.37584438935665 1752 564103 YBR002C RER2
SGTC_1977 st070720 65.3 µM 0.316213439328357 0.357971837021862 no 1205 0.375920253807727 1742 682188
SGTC_131 0141-0277 33.849 µM 0.315719179492066 0.358182306668007 no 1206 0.376107833816264 1844 1547771
SGTC_2213 7173844 200 µM 0.314229131796513 0.358817071211848 no 1207 0.376673509226169 1763 892728
SGTC_3105 9121040 49.47 µM 0.313886290714359 0.358963177754883 no 1208 0.376803701496694 1855 41448907
SGTC_3271 9137798 49.47 µM 0.312548709916597 0.359533403724318 no 1209 0.37731177528256 1875 6498326
SGTC_1243 0416-0003 5.65 µM 0.311159593341611 0.360125931230892 no 1210 0.377839649565454 1743 2141977
SGTC_963 1269-2853 151 µM 0.311019791414274 0.36018558236948 no 1211 0.377892787957646 1692 3668223
SGTC_1948 st076329 66.6 µM 0.310281736715805 0.360500554329293 no 1212 0.378173359132818 1783 24208413
SGTC_2421 5690543 90.72 µM 0.309914093736843 0.360657484856833 no 1213 0.378313142438169 1775 3397993
SGTC_1439 4092-1168 46 µM 0.308416700374615 0.361296898063958 no 1214 0.378882637936271 1797 2886240
SGTC_1322 1348-1070 12 µM 0.307461623971781 0.361704935036671 no 1215 0.379246014444266 1863 6758089
SGTC_1456 k015-0012 13 µM 0.305560089529616 0.36251779491575 no 1216 0.379969805908447 1936 2989616
SGTC_2384 9036245 200 µM 0.305539456881749 0.362526618279906 no 1217 0.379977661737446 1848 6462766
SGTC_675 1309-0189 238 µM 0.305517364025064 0.362536066170028 no 1218 0.379986073592202 1758 4246530
SGTC_2748 diazoxide 86.69 µM 0.304892524070706 0.362803310225274 no 1219 0.380224004889937 1834 3019 A potassium channel activatior.
SGTC_2457 5731572 11.68 µM 0.303186048562151 0.363533510013556 no 1220 0.380874040294036 1893 2865357
SGTC_2863 9028737 58.44 µM 0.302578492956221 0.363793602557343 no 1221 0.381105553362059 1900 6460917
SGTC_2741 miltefosine 3.04 µM 0.300363638428216 0.364742305200864 no 1222 0.381949898112877 1803 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_3329 9141233 27.5565 µM 0.300120252566322 0.364846606854053 no 1223 0.382042715774844 1873 4909101 YNL103W MET4
SGTC_1042 0350-0096 82 µM 0.299182526982437 0.365248557372161 no 1224 0.382400390257863 1723 3122515
SGTC_1431 4049-0260 9.09 µM 0.297658826233454 0.365901998293009 no 1225 0.382981785780209 1840 3854841
SGTC_2150 5556613 200 µM 0.296592551604677 0.366359503069233 no 1226 0.383388799047687 1816 743190
SGTC_2425 5628681 7.85 µM 0.295687505861287 0.36674797873613 no 1227 0.383734369820849 1879 5714958
SGTC_456 gingerol 170 µM 0.293615662015963 0.367637796298451 no 1228 0.384525803244649 1821 442793 A herb.
SGTC_2723 salbutamol 83.58 µM 0.293573394817549 0.36765595667342 no 1229 0.384541954114794 1873 9884233 β2-adrenoceptor agonist
SGTC_712 r015-0009 80.6 µM 0.293114756539349 0.367853032592347 no 1230 0.384717218905459 1865 6813872 YLR060W FRS1
SGTC_2134 5324836 1.464 µM 0.292939853449501 0.367928197255155 no 1231 0.384784062869817 1810 699272
SGTC_2788 5282734 71.43 µM 0.290828389263767 0.368835998000444 no 1232 0.385591285932151 1912 743706
SGTC_284 0988-0104 32.6 µM 0.290783355535202 0.368855367749023 no 1233 0.385608507958594 1865 4666532
SGTC_2915 7971052 15.16 µM 0.290697220659667 0.368892416705906 no 1234 0.385641448721892 1872 5741558
SGTC_1403 3909-7815 62.9 µM 0.289432617800029 0.369436496935498 no 1235 0.38612516860439 1798 6615483
SGTC_2642 cholecalciferol 100 µM 0.288588883661193 0.369799649000256 no 1236 0.386448001641365 1856 9821465 A vitamin D precursor, similar to steriods.
SGTC_2649 anisomycin 9.56 µM 0.288100446866969 0.370009930446869 no 1237 0.386634925284939 1810 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1088 bifonazole 369 nM 0.287702227502848 0.37018140031736 no 1238 0.386787342392355 1811 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_749 1000-0129 128 µM 0.287312930148672 0.370349053390088 no 1239 0.386936361511674 1926 708470
SGTC_2611 pyromycin 23.93 µM 0.285947607773169 0.370937231555511 no 1240 0.38745912481788 1729 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2487 5918373 44.05 µM 0.285674793125923 0.371054795769221 no 1241 0.38756360632178 1923 2876279
SGTC_1662 st014054 52 µM 0.283138756503584 0.372148226486404 no 1242 0.388535236609962 1881 2838777
SGTC_2533 agelasine 13.65 µM 0.281965902059774 0.372654260702444 no 1243 0.388984828048856 1973 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_294 k038-0071 157 µM 0.281912667627311 0.372677234201139 no 1244 0.389005237988105 1805 24152826
SGTC_1404 3909-7820 48.3 µM 0.280271550324552 0.373385685742064 no 1245 0.389634587992423 1913 23741373
SGTC_647 0140-0236 81 µM 0.27984667895552 0.37356916771894 no 1246 0.389797568623832 1839 990837
SGTC_2347 9049783 174.81 µM 0.279574330236076 0.373686797409786 no 1247 0.389902051770521 1884 6467988 YPL169C MEX67
SGTC_635 k038-0028 24.7 µM 0.27952366527111 0.373708681330604 no 1248 0.389921489622364 1864 4035102
SGTC_3321 9137793 26.8275 µM 0.277176760306679 0.374722834569505 no 1249 0.390822191692607 1828 4904192
SGTC_2906 7926292 26.41 µM 0.277071623323828 0.374768287093666 no 1250 0.390862555222669 1807 2966319
SGTC_1385 3091-4834 14.1 µM 0.276933085212393 0.374828182156116 no 1251 0.390915743699635 1883 4072814
SGTC_288 1315-0019 35.1 µM 0.276840910051047 0.37486803450247 no 1252 0.390951133333773 1836 6811474
SGTC_1319 1306-0155 43.7 µM 0.276788280145079 0.374890789878788 no 1253 0.390971340409354 1846 3122360
SGTC_1000 4048-0884 8.67 µM 0.276466434537247 0.375029954415761 no 1254 0.39109491835146 1833 13040088
SGTC_1660 st012960 28.1 µM 0.276271521377964 0.375114241867131 no 1255 0.391169763828473 1819 24207266
SGTC_3114 9122766 49.47 µM 0.275567991929277 0.375418522858119 no 1256 0.391439948401059 1772 17176985
SGTC_859 0439-0102 54.6 µM 0.275524693011297 0.375437252451622 no 1257 0.391456578699169 1954 610143
SGTC_1495 4469-0029 237 µM 0.275418633621108 0.375483131264821 no 1258 0.391497314949588 1794 793680
SGTC_1817 st052116 64.4 µM 0.275342881225166 0.375515901058812 no 1259 0.391526411343888 1885 4361398
SGTC_64 000l-0018 272.079 µM 0.275281415577759 0.375542491196041 no 1260 0.391550020663128 1781 6811119
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.273170373400097 0.376456089459094 no 1261 0.392361126382201 1921 23847180
SGTC_2549 cedrol 20.94 µM 0.272595719304539 0.376704903333324 no 1262 0.392582001433392 1917 6708665 A sedative which affects the nervous system.
SGTC_3304 9125678 46.087 µM 0.270915993000173 0.377432485001473 no 1263 0.393227822113513 1790 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1658 st012944 20 µM 0.269293211931033 0.378135813973774 no 1264 0.393852027701884 1905 24207260
SGTC_2702 st077768 96.8 µM 0.267365188447065 0.378971963017959 no 1265 0.394593999844487 1796 6484119
SGTC_1775 st081588 35.1725 µM 0.266913639549831 0.379167873682326 no 1266 0.39476782733823 1802 1426443 YGL099W LSG1
SGTC_2761 levamisole 97.89 µM 0.266706233173722 0.379257870180669 no 1267 0.394847677167173 1945 26879 An alkaline phosphatase inhibitor.
SGTC_207 4185-0010 4.486 µM 0.266491836805961 0.379350906611648 no 1268 0.394930222731019 1949 3761753
SGTC_2265 7929201 200 µM 0.266176890485468 0.379487588955388 no 1269 0.395051489967893 1734 1265108
SGTC_2782 7736369 71.43 µM 0.265325755516536 0.379857045062391 no 1270 0.395379262632473 1794 2950836 YOL077C BRX1
SGTC_3289 9119912 71.43 µM 0.264898260207917 0.380042651338527 no 1271 0.39554391931359 1851 17014829
SGTC_2980 9014342 25.29 µM 0.264893346579359 0.380044784856674 no 1272 0.395545811984963 1845 2996599
SGTC_1180 1193-0155 285 µM 0.264828849631 0.380072790040827 no 1273 0.395570655671973 1817 2921347
SGTC_1911 st060208 74.3 µM 0.262349106750407 0.381149993371407 no 1274 0.396526152849999 1917 688783
SGTC_403 arphamenine a 50 µM 0.261022965919401 0.381726449327491 no 1275 0.397037398388275 1868 5487158 An arginine aminopeptidase inhibitor.
SGTC_375 3970-0961 9.27 µM 0.260406589887631 0.381994469271535 no 1276 0.397275080133246 1862 2898222
SGTC_585 0kpi-0023 191 µM 0.259497526914835 0.382389862028745 no 1277 0.397625694962064 1933 64601
SGTC_772 k072-0172 35.3 µM 0.259414391047751 0.382426027719098 no 1278 0.397657763614439 1731 5861980
SGTC_301 4119-0100 24.5 µM 0.258981010950528 0.382614572941321 no 1279 0.397824945925676 1851 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_275 trichlorophene 5.69 µM 0.258532033084322 0.382809933435497 no 1280 0.397998165080016 1860 62616
SGTC_304 1310-0298 97 µM 0.256952253921423 0.383497568069151 no 1281 0.3986078158039 1869 1550234
SGTC_433 pimozide 108 µM 0.256113244831855 0.38386291516799 no 1282 0.398931697545422 1704 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1657 st012939 43.4 µM 0.255618651191037 0.384078334711198 no 1283 0.399122657599148 1956 24207257
SGTC_834 0312-0008 75.7 µM 0.254758191235671 0.384453192123679 no 1284 0.399454934264376 1850 6385573 YIL048W NEO1
SGTC_657 3534-0529 86.7 µM 0.254724290290885 0.384467963207957 no 1285 0.399468027003362 1949 1049549
SGTC_2745 rifampicin 24.3 µM 0.252550616737995 0.385415410471369 no 1286 0.400307747589054 1982 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_3225 9130819 49.47 µM 0.251772781330879 0.385754615046746 no 1287 0.400608348535182 1938 4547121
SGTC_3299 9121982 43.1275 µM 0.248855547858815 0.387027561580237 no 1288 0.401736260686517 1837 17594604 YPL160W CDC60
SGTC_1087 pterostilbene 9.05 µM 0.248620692153244 0.3871300948808 no 1289 0.401827100480124 1969 5281727 Similar to reservatol, lowers cholesterol.
SGTC_2575 plumbagin 510 nM 0.248229790453383 0.387300772200094 no 1290 0.401978309033476 1783 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3314 9135860 59.4275 µM 0.248187002385206 0.387319455849084 no 1291 0.401994861200736 2002 25252478
SGTC_2058 5236698 133 µM 0.247987661870641 0.3874065024382 no 1292 0.402071976546194 1847 766665
SGTC_907 3448-6986 75.5 µM 0.247099207690822 0.387794535033869 no 1293 0.40241572344795 1958 590582
SGTC_638 3970-0837 4.09 µM 0.245633286979139 0.388435021156216 no 1294 0.402983059614835 1833 4118451 YLR208W SEC13
SGTC_2760 etidronate 98.04 µM 0.243805893373219 0.389233865832267 no 1295 0.403690577896247 1847 3305 A chelator and antioxidant.
SGTC_1840 st055363 71 µM 0.243219938562746 0.389490115173642 no 1296 0.403917510904157 1794 676033
SGTC_2323 6148992 148.28 µM 0.242003505089259 0.390022238316031 no 1297 0.404388723639244 1840 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_3047 9092122 49.47 µM 0.241632801148587 0.390184442055796 no 1298 0.404532351720909 1843 17173831
SGTC_1163 k060-0048 49.9 µM 0.240205066807379 0.390809334201181 no 1299 0.405085642957003 1850 6809982
SGTC_2133 5320837 200 µM 0.237969820820417 0.391788224779954 no 1300 0.405952250687618 1954 2841355
SGTC_3093 9117344 49.47 µM 0.237283369283049 0.392088983227648 no 1301 0.406218481561129 1901 24824913
SGTC_1061 3448-9325 110 µM 0.235820298212961 0.392730220853707 no 1302 0.406786058307288 2019 723482
SGTC_2694 st077685 81.9 µM 0.23579154655112 0.392742825111593 no 1303 0.406797214054599 1832 2838096
SGTC_2489 cantharidin 73.42 µM 0.234870888410365 0.393146485965934 no 1304 0.407154472632395 1806 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1685 st024049 53.0905 µM 0.233728402157097 0.393647566684027 no 1305 0.407597918325731 1930 1941139
SGTC_1381 2324-0066 62.1 µM 0.233570926313517 0.393716647526543 no 1306 0.407659050447675 1898 10885928
SGTC_3195 9113082 49.47 µM 0.233507535830477 0.393744456342146 no 1307 0.407683659267811 2044 17018038
SGTC_3204 9114183 49.47 µM 0.232897432709194 0.394012130596128 no 1308 0.407920526017864 1822 17027248
SGTC_2480 5767542 37.17 µM 0.232000430066569 0.394405768924656 no 1309 0.408268839885002 1937 2867358
SGTC_1638 st008370 60.6 µM 0.231763185150614 0.394509898925173 no 1310 0.408360976266451 1927 24207134
SGTC_2299 7976368 114.88 µM 0.231676570514188 0.39454791713874 no 1311 0.408394615169591 1983 2979718
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.23137841708196 0.394678794855516 no 1312 0.408510415474748 1944 4000243
SGTC_2288 7946289 167.31 µM 0.231152808301808 0.394777836204005 no 1313 0.408598045352583 1987 1246052
SGTC_542 3381-0244 89.3 µM 0.231148851320705 0.394779573363521 no 1314 0.408599582344953 2011 1112843
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM 0.231073478335506 0.394812663357008 no 1315 0.408628859402946 2006 1241132 A phosphatase inhibitor.
SGTC_1479 0549-0158 134 µM 0.229317500471974 0.395583781115709 no 1316 0.409311076227158 1887 5440202
SGTC_813 k007-0158 173 µM 0.229209218727807 0.395631345231958 no 1317 0.409353153897103 1976 6523916
SGTC_464 bw-b 70c 158 µM 0.22884917098374 0.395789511900024 no 1318 0.409493073909693 1989 5353454
SGTC_3129 9127257 49.47 µM 0.228410275154621 0.395982339235286 no 1319 0.409663651075151 1770 837894
SGTC_1562 morin hydrate 59.1 µM 0.227795427011402 0.396252513399888 no 1320 0.40990264098008 1894 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3199 9111318 49.47 µM 0.227203475187669 0.396512673641038 no 1321 0.410132762773545 1965 8548020
SGTC_3071 9117417 49.47 µM 0.226115101620416 0.396991129245127 no 1322 0.410555949673024 2038 45595590 YGL055W OLE1
SGTC_3250 9135583 49.47 µM 0.226043994115765 0.397022393939288 no 1323 0.410583601681579 2019 7699353
SGTC_2289 7946404 165.07 µM 0.224533441890894 0.397686712713011 no 1324 0.411171124125734 1882 1246120 YPR165W RHO1
SGTC_944 3370-0224 231 µM 0.22418953095616 0.397838001261166 no 1325 0.411304914624843 1845 4580514
SGTC_1974 st069448 26.9 µM 0.223960383281733 0.397938813271589 no 1326 0.411394064891349 2023 6323587 YNR016C ACC1
SGTC_2911 7942208 15.64 µM 0.22356074597446 0.398114647375777 no 1327 0.411549555365349 1879 1243384
SGTC_295 k015-0027 31 µM 0.222053632499501 0.398777939392301 no 1328 0.412136066322059 1955 3887424
SGTC_1515 3460-0031 42.1 µM 0.219490482052827 0.399906671946046 no 1329 0.413133996667617 1973 2876596
SGTC_1994 st072947 40.9 µM 0.218158008806958 0.400493783348589 no 1330 0.413653000594226 1947 5286565 YDL195W SEC31
SGTC_1454 4239-0054 42.6 µM 0.218141026610511 0.400501267460481 no 1331 0.413659616206741 2032 1340767
SGTC_2819 7996655 46.38 µM 0.218116478425925 0.400512085993717 no 1332 0.413669179281418 1999 6456960
SGTC_522 1273-0010 11.6 µM 0.216700889749462 0.401136073322664 no 1333 0.414220727280511 1935 5705015
SGTC_845 0330-0138 4.51 µM 0.214108132853026 0.402279606036907 no 1334 0.41523136687907 2033 9039800
SGTC_3334 9142812 21.919 µM 0.213613209903503 0.402497986701063 no 1335 0.415424348577302 1975 45283678
SGTC_1302 1159-0335 255 µM 0.213470268701171 0.402561063992594 no 1336 0.415480088397815 1901 649284
SGTC_837 0091-0265 12.5 µM 0.213441892676871 0.402573586105686 no 1337 0.415491153810745 1900 759367
SGTC_3049 9092223 49.47 µM 0.21335192851346 0.402613287233882 no 1338 0.415526236357118 1947 8623917
SGTC_106 0092-0003 11.579 µM 0.211358579479165 0.403493207850019 no 1339 0.416303737696503 2039 1072148
SGTC_1915 st067105 30.6 µM 0.21128200043051 0.403527021784228 no 1340 0.416333613737573 1964 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2553 4-methylesculetin 85.09 µM 0.211225607886397 0.40355192270843 no 1341 0.416355614658988 1869 5319502
SGTC_550 4123-0385 25.7 µM 0.211194185170224 0.403565798022126 no 1342 0.416367873994543 1918 5731123
SGTC_989 1501-0895 10.3 µM 0.207247667882253 0.405309419155386 no 1343 0.41790822087627 2052 2830112
SGTC_2468 5987765 72.9 µM 0.205956317744389 0.405880364078921 no 1344 0.41841251656352 1980 26772094
SGTC_2557 derrustone 83.84 µM 0.205900236091601 0.405905164018473 no 1345 0.418434420512808 1858 629853 An antioxidant.
SGTC_2749 bexarotene 57.39 µM 0.203720275432511 0.406869458901464 no 1346 0.419286048473825 1899 82146 An retinoic acid receptor inhibitor.
SGTC_1997 st073024 93.8 µM 0.203023069021195 0.40717798423478 no 1347 0.419558500606361 2059 686268
SGTC_849 0386-0493 241 µM 0.203007854887363 0.407184717382743 no 1348 0.419564446368267 1945 726119
SGTC_418 lividomycin a 100 µM 0.200804474466423 0.408160131303834 no 1349 0.420425732038352 2049 72394 An antibiotic.
SGTC_544 k015-0020 52.4 µM 0.200612510432728 0.408245138864088 no 1350 0.420500787516282 1930 3008304
SGTC_2419 paclitaxel 166.5 µM 0.200024315810432 0.408505636349947 no 1351 0.420730782064001 1925 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1996 st072960 66.8 µM 0.199673434815561 0.408661052504601 no 1352 0.420867995658467 2072 1719405
SGTC_326 k292-0812 17.5 µM 0.199522657981029 0.408727840689085 no 1353 0.420926960573256 2060 3579357
SGTC_3143 9086658 49.47 µM 0.196798914227524 0.409934806231546 no 1354 0.421992450411223 1909 25236626
SGTC_942 3253-1115 227 µM 0.19658083318915 0.410031480989685 no 1355 0.422077785415847 2045 46497897
SGTC_3146 9095609 49.47 µM 0.195985337969055 0.410295490312845 no 1356 0.422310821029411 1989 17173999
SGTC_1501 4491-0275 38.4 µM 0.195736489934506 0.410405827686293 no 1357 0.422408210989157 2082 5104718
SGTC_1643 st009866 20.2 µM 0.195591403846818 0.410470161055222 no 1358 0.4224649945323 2047 3156273 YOR207C RET1
SGTC_1055 3448-0672 86 µM 0.194255908174082 0.411062452999458 no 1359 0.42298775406396 1987 748378
SGTC_1068 loratadine 26.9 µM 0.193336397843437 0.411470373538691 no 1360 0.423347761338203 1928 3957 A H1 histamine antagonist.
SGTC_100 0086-0128 49.5915 µM 0.193156662769083 0.411550120249447 no 1361 0.423418138817268 1857 93297
SGTC_735 3076-0345 636 µM 0.193013118902728 0.411613811896585 no 1362 0.423474346938693 2050 2888990
SGTC_1715 st032160 10.2275 µM 0.192900166236634 0.411663931602767 no 1363 0.423518577420284 2045 5289825
SGTC_1234 0326-0494 15.5 µM 0.192528825399096 0.411828714261342 no 1364 0.423663995421648 2045 1547813
SGTC_1373 2887-0003 58.5 µM 0.192199482679095 0.411974873249458 no 1365 0.42379297555523 1955 776948
SGTC_589 1227-0070 34.1 µM 0.191794258217505 0.412154724546409 no 1366 0.423951684374953 1995 2841384
SGTC_2355 9061122 103.12 µM 0.191344517922558 0.412354354964837 no 1367 0.424127842554227 2055 5302957
SGTC_2651 TUB2.036 5 µM 0.190897093689694 0.412552979834434 no 1368 0.424303108601374 2073 15992207 YFL037W TUB2
SGTC_2310 7668677 200 µM 0.190715326301757 0.41263367816196 no 1369 0.424374315217837 2008 2197143
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.19009899638922 0.412907334437757 no 1370 0.424615778253626 2038 17037758
SGTC_3133 9127736 49.47 µM 0.18990488286236 0.412993531440207 no 1371 0.424691833064393 2117 27243420
SGTC_1442 4112-3290 3 µM 0.189342436531807 0.413243311986773 no 1372 0.424912218634798 2042 704353
SGTC_1038 k292-0204 154 µM 0.188791528767459 0.413488002342384 no 1373 0.425128105757488 1915 4454212
SGTC_1646 st011709 75.6 µM 0.1877183281453 0.413964769906175 no 1374 0.425548730950697 2082 5757843
SGTC_807 1315-0151 48 µM 0.187123539364711 0.414229058489172 no 1375 0.425781886191508 2107 4011080
SGTC_1261 0712-0010 12.7 µM 0.186769464851795 0.414386406491236 no 1376 0.425920694560818 2069 2840123
SGTC_722 3534-0461 190 µM 0.185224236507139 0.41507325464914 no 1377 0.426526580004167 1919 658262
SGTC_601 0986-0029 62.9 µM 0.18510820454113 0.415124840926217 no 1378 0.426572083261987 1979 24747981
SGTC_3065 9113888 49.47 µM 0.183828511033755 0.415693872603169 no 1379 0.427073994352889 2030 16648368
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.182026237719438 0.416495575536488 no 1380 0.427781067571739 2038 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_3234 9132280 49.47 µM 0.181929514442988 0.416538610682169 no 1381 0.427819020914152 1991 17612295
SGTC_10 0279-0212 42.575 µM 0.181855298301589 0.416571632393013 no 1382 0.42784814311236 2051 39851 YBR002C RER2
SGTC_2155 5570423 76 µM 0.181821054886999 0.416586868847597 no 1383 0.427861580261258 1953 797402
SGTC_2383 9036125 200 µM 0.181760282051224 0.416613909758356 no 1384 0.427885427786588 1985 79580
SGTC_3068 9116768 49.47 µM 0.181163772246112 0.416879348089198 no 1385 0.428119514799889 1984 41904888
SGTC_1656 st012921 11 µM 0.179682599343278 0.41753861247959 no 1386 0.42870087740664 2054 6732821
SGTC_2851 9015922 71.43 µM 0.179172845298307 0.417765555776325 no 1387 0.428900992495867 2040 2996893
SGTC_851 0394-0702 453 µM 0.178587432738828 0.418026216146915 no 1388 0.429130831533939 2106 762646
SGTC_1648 st011736 69.8 µM 0.177553896512057 0.418486495580964 no 1389 0.429536667183625 2074 2855514
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.177513239921153 0.418504604046803 no 1390 0.429552633213678 2048 688751
SGTC_2311 7694451 200 µM 0.177315954728416 0.41859247742167 no 1391 0.429630109651055 2019 2163142
SGTC_2393 9031399 185.94 µM 0.177222446060448 0.418634128810403 no 1392 0.429666832656839 2045 1526623 YDL150W RPC53
SGTC_327 1273-0057 3.96 µM 0.176109129258859 0.419130101361412 no 1393 0.430104104454697 2082 3108138
SGTC_1547 harmine 94.2 µM 0.175097222639729 0.419581008128242 no 1394 0.430501620285709 2050 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_3278 9139605 49.47 µM 0.173496429783133 0.42029453875768 no 1395 0.43113061697442 2074 7958859
SGTC_2356 9061756 188.97 µM 0.173379857398296 0.420346509502104 no 1396 0.431176428397881 2094 20104043
SGTC_2436 5633522 8.09 µM 0.172511687645373 0.420733603869846 no 1397 0.431517636847468 2124 5724242
SGTC_2858 9025781 8.96 µM 0.172017599499743 0.420953939206548 no 1398 0.431711846418089 2098 4894980 YPL153C RAD53
SGTC_1071 trifluoperazine 6.31 µM 0.170681307119637 0.421549973801856 no 1399 0.432237180945396 2056 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_3131 9127911 49.47 µM 0.170309684481318 0.421715762911553 no 1400 0.432383297705736 2026 45595681
SGTC_270 tamoxifen 5.46 µM 0.170154768186907 0.421784878609675 no 1401 0.432444211331848 2124 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_3350 9150499 3.57 µM 0.169332372258905 0.422151829751742 no 1402 0.432767607126316 2088 4910996 YPR165W RHO1
SGTC_76 0433-0009 400.328 µM 0.169012931193062 0.422294381852051 no 1403 0.432893235052176 1949 2841569
SGTC_3262 9137218 49.47 µM 0.168404954150921 0.422565722618031 no 1404 0.433132355459112 2103 17650664
SGTC_1467 k284-1082 293 µM 0.167795180013745 0.422837902341022 no 1405 0.433372207264995 2138 3334705
SGTC_2033 5192550 145 µM 0.16751476642926 0.422963080554094 no 1406 0.433482514880715 1976 182073
SGTC_1502 4534-4282 27.7 µM 0.165557558759003 0.423837005077617 no 1407 0.43425257473394 2005 3278949
SGTC_629 3448-6466 76.7 µM 0.165515556262462 0.423855763986373 no 1408 0.434269103286585 2039 573744
SGTC_1941 st076221 61.8 µM 0.164872458078605 0.424143002247838 no 1409 0.434522185484555 2144 2828568
SGTC_1423 4048-0112 5.59 µM 0.16461724902194 0.424257001939065 no 1410 0.434622626844102 2111 X1423
SGTC_2768 sulfasalazine 50.2 µM 0.164487910054806 0.424314778963905 no 1411 0.434673531749937 2113 5384001 An antioxidant and salicylic acid derivative.
SGTC_1730 st033808 45.1 µM 0.163420998873388 0.424791440914804 no 1412 0.435093485209889 1949 1045166
SGTC_2216 7189485 200 µM 0.163220710001894 0.4248809358898 no 1413 0.435172330319996 2107 731273
SGTC_1713 st033146 12.748 µM 0.162830645802628 0.425055239187334 no 1414 0.435325889205729 2110 674619
SGTC_2755 lomerizine 42.69 µM 0.160224440208482 0.426220217322015 no 1415 0.436352138799345 2009 3949 A calcium channel blocker.
SGTC_373 0844-0104 25.9 µM 0.15995941771694 0.426338719056382 no 1416 0.436456521237794 2139 5375804
SGTC_2458 5808907 16.39 µM 0.15895788912936 0.426786600921792 no 1417 0.436851025756487 2141 2731747
SGTC_514 4466-0038 2.65 nM 0.156577826262333 0.427851338701706 no 1418 0.437788789522995 2019 5722064
SGTC_3179 9107801 49.47 µM 0.156460439772931 0.427903866032892 no 1419 0.4378350498241 2050 4818259
SGTC_249 wiskostatin 11.211 µM 0.155507181918234 0.428330470800454 no 1420 0.438210746232901 2116 2775510 A n-wasp and actin depolymerizer.
SGTC_2922 7999257 32.47 µM 0.155138135462691 0.428495650079135 no 1421 0.438356209184937 2112 2988377
SGTC_2955 9076254 12.21 µM 0.153884403495408 0.429056893812351 no 1422 0.43885044091323 2120 16459619
SGTC_1361 1608-0041 5.61 µM 0.153425638143748 0.429262299919746 no 1423 0.439031313960421 2041 X1361
SGTC_3089 9117425 49.47 µM 0.153204334784491 0.429361392418782 no 1424 0.439118569683143 1969 9401657
SGTC_2231 micatex 6.853 µM 0.152863374759459 0.429514072019455 no 1425 0.439253009551475 2063 20737 An antifungal of unknown mechanism.
SGTC_2967 9089538 49.85 µM 0.152784104441296 0.429549570245008 no 1426 0.439284266686764 2160 728216
SGTC_1265 0819-1001 68.8 µM 0.152228778480827 0.429798268012644 no 1427 0.439503248264073 2119 3106768
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 0.151682399976657 0.430042985932342 no 1428 0.439718719660761 2131 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3223 9129970 49.47 µM 0.150481836119491 0.430580801753403 no 1429 0.440192240115775 2050 17248386
SGTC_160 3453-0671 289.699 µM 0.15033472524372 0.430646711795239 no 1430 0.440250268756826 2078 5322268
SGTC_2791 5663188 71.43 µM 0.149617845440329 0.430967922852785 no 1431 0.440533064021967 2109 54690634
SGTC_1554 st069299 38.7 µM 0.148190054898605 0.431607806273775 no 1432 0.441096390101854 2073 24207999
SGTC_155 k072-0202 43.6 µM 0.145557825793732 0.43278794426184 no 1433 0.442135231719038 2154 5857737
SGTC_784 4579-0127 173 µM 0.145503299459847 0.432812397066072 no 1434 0.442156755440912 2138 1948547
SGTC_2142 5622915 118.518 µM 0.14486766058068 0.433097473755906 no 1435 0.442407680077281 2026 5322196
SGTC_880 0833-0487 87.2 µM 0.14424842704408 0.433375226322937 no 1436 0.442652150765984 2089 76075
SGTC_3030 9087619 49.47 µM 0.143574013938321 0.433677766707842 no 1437 0.44291843094746 2069 25236973
SGTC_1609 st001574 46.4 µM 0.14357100687782 0.433679115756389 no 1438 0.442919618290365 2084 3960012
SGTC_2402 5553605 200 µM 0.140135377440798 0.435220932770461 no 1439 0.444276514607406 2111 6758546
SGTC_1137 ixabepilone 100 µM 0.139864107296802 0.435342713710162 no 1440 0.444383680353571 2083 154225 A novel microtubule stabilizer.
SGTC_1085 doxorubicin 7.67 µM 0.13949751568314 0.435507296930163 no 1441 0.444528509472297 2167 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_11 0438-0307 1.3 µM 0.139445263209719 0.435530756861393 no 1442 0.444549153427708 2173 4011476
SGTC_2153 5569715 200 µM 0.137860449768721 0.436242402166999 no 1443 0.445175354194491 2178 2054701
SGTC_979 1426-2828 121 µM 0.136233883356231 0.436973010907132 no 1444 0.445818194909734 2104 747872
SGTC_2398 5228213 48.84 µM 0.13587417241606 0.437134612253632 no 1445 0.44596037676046 2179 80771 YMR134W ERG29
SGTC_548 1436-0017 110 µM 0.134261631017463 0.437859180419473 no 1446 0.446597846248047 2173 9677137
SGTC_2149 5554786 194.827 µM 0.133160685541742 0.438353991486038 no 1447 0.447033151142894 2044 745063 YPR165W RHO1
SGTC_1986 st071812 45 µM 0.132812508835681 0.438510496796382 no 1448 0.447170830691215 2172 11838594
SGTC_2240 6690706 185.951 µM 0.129339320577365 0.440072216182593 no 1449 0.448544579697865 1987 805876
SGTC_225 nsc-122657 1.016 µM 0.129227823184651 0.440122366577921 no 1450 0.448588690537643 2140 275685
SGTC_931 2812-0076 566 µM 0.126999748116915 0.44112473248114 no 1451 0.449470298954554 2100 3450959
SGTC_173 1273-0061 2.693 µM 0.126629830460314 0.44129118764255 no 1452 0.44961669284913 2035 2847414 YPL266W DIM1
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.126037339993019 0.441557817481348 no 1453 0.449851183600881 2089 115019
SGTC_783 0848-0141 92.7 µM 0.125715391632917 0.441702710317604 no 1454 0.449978608885921 2189 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_923 1900-2434 73.3 µM 0.125001699103881 0.442023935376791 no 1455 0.450261102600608 2181 5910570
SGTC_1733 st037357 54.9 µM 0.12422129350636 0.442375230879461 no 1456 0.450570031518318 2150 1272339 YGL099W LSG1
SGTC_476 mead acid 10 µM 0.124152980953919 0.442405983579074 no 1457 0.450597074939811 2137 5312531 An omega 9 fatty acid.
SGTC_236 1509-0011 5.31 µM 0.123894742968206 0.442522239362625 no 1458 0.450699307691176 2157 3107280
SGTC_2366 9070441 60.58 µM 0.121299294583528 0.443690953714187 no 1459 0.451726989367242 2151 6837235
SGTC_2367 9070478 135.38 µM 0.121237432537968 0.443718815828692 no 1460 0.45175148795058 2113 572802
SGTC_482 fipronil 114 µM 0.120827199839186 0.443903588016814 no 1461 0.45191395279004 2201 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.120655578013628 0.443980891521648 no 1462 0.451981922732963 2182 165506
SGTC_1291 0993-0025 5.79 µM 0.120625253307482 0.443994550880546 no 1463 0.451993932823523 2164 4353356
SGTC_2229 7354935 190 µM 0.12035074479412 0.444118202599373 no 1464 0.452102653833476 2185 318112
SGTC_3292 9120825 59.784 µM 0.120329964669079 0.444127563179804 no 1465 0.452110884093174 2209 24824900
SGTC_329 k048-0121 21.3 µM 0.119468678669705 0.444515563989049 no 1466 0.452452026543553 2090 6832902
SGTC_628 1636-0253 16 µM 0.118871229199109 0.444784740314742 no 1467 0.452688687943024 2177 4456143
SGTC_1845 st056753 3.01 µM 0.118442857563882 0.444977755586246 no 1468 0.452858384661986 2146 5375839
SGTC_2795 7780010 54.55 µM 0.117697027957935 0.445313841862632 no 1469 0.453153860879702 2102 953673
SGTC_1583 clindamycin 39.6 µM 0.115113736676628 0.446478228795267 no 1470 0.454177485996131 2021 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1954 st077032 68.9 µM 0.11416040197844 0.446908049892438 no 1471 0.454555320639083 1976 698907
SGTC_1462 k081-0014 26.5 µM 0.113177619540981 0.447351213104775 no 1472 0.454944869333655 2163 3270634
SGTC_2060 5238662 140 µM 0.112521125011346 0.447647280922436 no 1473 0.455205110384396 2118 790130
SGTC_605 1315-0399 119 µM 0.109314555194792 0.449093805311411 no 1474 0.456476501201507 2158 24020461
SGTC_2329 6138490 200 µM 0.108466136061648 0.449476651992064 no 1475 0.456812970752615 2069 720019
SGTC_706 4262-0057 46.9 µM 0.108340276860814 0.449533449607497 no 1476 0.456862887155656 2192 883298
SGTC_1899 st063254 59.6 µM 0.108229602810274 0.449583395337762 no 1477 0.456906781612835 2136 3093813
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.108182615577875 0.449604600293767 no 1478 0.456925417387442 2134 688669
SGTC_1558 st069300 45.6 µM 0.107856136442565 0.449751941644006 no 1479 0.457054906060707 2225 24208000
SGTC_171 k064-0041 9.68 µM 0.10772233307282 0.449812329646863 no 1480 0.457107976683857 2094 53325
SGTC_1207 2099-0101 141 µM 0.107431987069769 0.449943372309645 no 1481 0.457223139666615 2207 5837381
SGTC_1017 4239-0030 168 µM 0.10731932659429 0.449994221143612 no 1482 0.457267826341419 2023 1149593
SGTC_1173 0443-0020 122 µM 0.107070873614289 0.450106362256564 no 1483 0.457366376898057 2108 5331295
SGTC_331 k048-0133 24.5 µM 0.106971050441161 0.450151419315643 no 1484 0.457405973174129 2202 6813582
SGTC_2938 9059746 27.26 µM 0.105989715716109 0.450594397243574 no 1485 0.457795255946385 2172 6471769
SGTC_2184 6075246 200 µM 0.105519139965283 0.450806838652079 no 1486 0.457981941637196 2146 2267320
SGTC_3118 9124250 49.47 µM 0.105234816350614 0.45093520337331 no 1487 0.458094742319451 2107 1504786
SGTC_103 0844-0104 51.839 µM 0.104968610255949 0.451055393157063 no 1488 0.458200358235446 2210 5375804
SGTC_1632 st005650 90 µM 0.104323360155617 0.45134673667998 no 1489 0.458456370167408 2141 2759605
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.104259582390752 0.451375535061799 no 1490 0.458481675818337 2168 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2131 toluylene red 5.2905 µM 0.101435330109342 0.452651059874072 no 1491 0.45960244586279 2137 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2043 5101342 149 µM 0.101434361096109 0.452651497596809 no 1492 0.459602830459478 2149 678451
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0996700533602683 0.453448565729385 no 1493 0.460303138040499 2159 390807
SGTC_1934 st074720 32.6 µM 0.0982978652553504 0.45406861429375 no 1494 0.460847886626756 2214 17250992
SGTC_3245 9134821 49.47 µM 0.098038833978442 0.454185674973307 no 1495 0.460950728414529 2209 17014901
SGTC_570 0987-0065 62.6 µM 0.0972555106892136 0.454539696384253 no 1496 0.461261742888895 2234 3104428
SGTC_2466 5983409 37.09 µM 0.0971921764647287 0.454568321743514 no 1497 0.461286890454151 2113 2879657
SGTC_245 methotrexate 289.6 µM 0.0968996389944218 0.454700543840275 no 1498 0.461403047749997 2173 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2063 5246145 200 µM 0.0950366540686725 0.455542699359676 no 1499 0.462142856465429 2183 711240
SGTC_1797 st048695 56.8 µM 0.0945772388531938 0.455750407184267 no 1500 0.462325314771961 2249 592262 YIL048W NEO1
SGTC_1758 st042942 75.2445 µM 0.0929617505532837 0.456480886932295 no 1501 0.462966974113872 2232 669317
SGTC_648 0375-0473 33.3 µM 0.0920508965061422 0.456892815298936 no 1502 0.46332880082378 2174 1713139
SGTC_2846 9008642 19.48 µM 0.0899571769969466 0.457839862494044 no 1503 0.464160622304202 2111 2992898
SGTC_2520 obtusaquinone 4.71 µM 0.0893291136023586 0.458123999851424 no 1504 0.464410178621889 2231 5967872
SGTC_2407 paclitaxel 400 µM 0.0890569498360914 0.458247134034388 no 1505 0.464518325223854 2134 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_946 3434-1334 87.4 µM 0.0879041275927796 0.458768746009972 no 1506 0.464976437981029 2204 4047976
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.0875973352475596 0.458907570875874 no 1507 0.465098360101764 2274 229346 A bile salt which induces apoptosis.
SGTC_2219 9098279 200 µM 0.0873277134718563 0.459029580036091 no 1508 0.465205512999297 2261 902349
SGTC_566 0958-0068 16.5 µM 0.0873132064696907 0.459036144849612 no 1509 0.465211278433548 2227 6815365
SGTC_1337 1486-1011 40.3 µM 0.0871967764290579 0.459088833017973 no 1510 0.465257550817883 2268 X1337
SGTC_1067 clotrimazole 1.36 µM 0.087033721648635 0.459162621520417 no 1511 0.46532235389917 2156 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_220 paclitaxel 373.376 µM 0.0865429430567293 0.459384726017777 no 1512 0.4655174102397 2238 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3322 9139058 2.11 µM 0.0861310709817395 0.459571130732039 no 1513 0.465681112161476 2208 4908926 YPR165W RHO1
SGTC_913 3487-1245 167 µM 0.0860019158977698 0.459629585462764 no 1514 0.465732447102354 2196 4016153
SGTC_280 3448-3607 3.04 µM 0.0849353418013434 0.460112343039087 no 1515 0.466156397299274 2252 626179
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.0847267871269624 0.460206746892035 no 1516 0.466239299743385 2244 688662
SGTC_3286 9117135 37.221 µM 0.0842574803650224 0.460419190347742 no 1517 0.466425858945927 2159 3438150
SGTC_484 loperamide 105 µM 0.0820270153195987 0.461429019622361 no 1518 0.467312615360573 2263 3955 An opioid-receptor agonist.
SGTC_2005 4024620 188 µM 0.0813385460548386 0.461740770371058 no 1519 0.467586360105724 2246 236743
SGTC_2061 5245884 80.95 µM 0.0811199139840143 0.46183977566805 no 1520 0.467673294404422 2236 573863
SGTC_576 1073-0113 22.7 µM 0.0810727387172759 0.461861138815438 no 1521 0.467692052827926 2292 5439563
SGTC_328 k915-0120 63.5 µM 0.0808810058704123 0.461947965467221 no 1522 0.467768292794344 2258 6624543
SGTC_1228 0124-0032 52.5 µM 0.0805583438221042 0.462094087794711 no 1523 0.467896597649734 2215 X1228
SGTC_3101 9120531 49.47 µM 0.0790723454940697 0.462767110066467 no 1524 0.468487539860725 2262 24824904
SGTC_534 k292-0788 63.4 µM 0.0783693761572478 0.463085528586327 no 1525 0.46876711643745 2293 4146317
SGTC_1694 st024011 44.9 µM 0.0782947892740699 0.463119315014693 no 1526 0.468796781148879 2264 2787533
SGTC_2528 xanthyletin 44.79 µM 0.0780380179434171 0.463235629538471 no 1527 0.468898905622159 2202 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_98 0074-0023 107.663 µM 0.0763282079970944 0.464010233878219 no 1528 0.469578992281369 2101 3563821
SGTC_3019 9081971 49.47 µM 0.0761219745969865 0.464103674177145 no 1529 0.46966102883061 2259 16451803
SGTC_36 0335-0881 14.2 µM 0.0760356116668382 0.464142804111321 no 1530 0.469695383089964 2229 23828853
SGTC_2100 5377183 190 µM 0.07565937731077 0.464313275106482 no 1531 0.469845047762678 2229 2844202
SGTC_781 4335-2806 94.4 µM 0.0738247814290595 0.465144619923307 no 1532 0.470574904048781 2260 845254
SGTC_3006 9075424 71.4286 µM 0.0727492887987348 0.46563204903523 no 1533 0.471002812819554 2209 7465181
SGTC_1855 st056195 39.6 µM 0.0700175674810114 0.466870335542135 no 1534 0.472089838562432 2292 4028379
SGTC_391 gliotoxin 8.33 µM 0.0693178375520976 0.467187574487443 no 1535 0.472368313787478 2235 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2890 9046729 58.44 µM 0.0692956241858885 0.46719764577949 no 1536 0.472377154380377 2187 903329
SGTC_3298 9116858 71.43 µM 0.0683868306520715 0.467609700544785 no 1537 0.472738852452216 2254 2506942
SGTC_2679 rapamycin 1 nM 0.0674447185035225 0.46803689889155 no 1538 0.473113834995977 2230 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_540 1187-0821 17.3 µM 0.0673016000242921 0.468101798833271 no 1539 0.473170801571868 2180 847520
SGTC_664 1222-0054 14.9 µM 0.0666198601893876 0.468410959028 no 1540 0.473442167361813 2285 6813991
SGTC_2010 4012422 159 µM 0.0661571733374667 0.468620792393076 no 1541 0.473626346381898 2251 952393
SGTC_1057 3448-5381 134 µM 0.0659477248544626 0.468715782357891 no 1542 0.473709722157483 2274 5497911
SGTC_1621 st003705 32.4 µM 0.0652062933024367 0.469052053815858 no 1543 0.474004875232198 2283 24207032
SGTC_703 3875-0075 71.8 µM 0.0647480576406544 0.469259894674342 no 1544 0.474187299303461 2234 2850814
SGTC_2022 5136654 200 µM 0.0646607983755734 0.469299473602718 no 1545 0.474222037918045 2233 1713771
SGTC_1266 0828-0227 32.9 µM 0.0642801107045284 0.469472148897151 no 1546 0.474373595028245 2248 3913820
SGTC_678 1218-2179 85.9 µM 0.0629655235644517 0.470068473569342 no 1547 0.474896979016088 2307 6820081 YOR116C RPO31
SGTC_96 0929-0093 37.281 µM 0.0620322199283565 0.470491880768687 no 1548 0.475268586804065 2178 6991579
SGTC_2409 alverine citrate 63.97 µM 0.0618651661250047 0.47056767076735 no 1549 0.475335103872415 2243 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_780 0109-0199 192 µM 0.0615338095625445 0.470718005805983 no 1550 0.475467044637485 2300 610414
SGTC_627 1391-0720 175 µM 0.060951049767337 0.470982411514256 no 1551 0.475699096576452 2242 997839
SGTC_1956 st077085 54 µM 0.0605891226930302 0.471146628987863 no 1552 0.475843218221322 2235 24208685
SGTC_3188 9110789 49.47 µM 0.0605111701398151 0.471181999108022 no 1553 0.475874259834221 2279 849217
SGTC_3310 9130229 44.1445 µM 0.0600037996827422 0.471412218457154 no 1554 0.476076304218051 2282 7761258
SGTC_3255 9139072 49.47 µM 0.0595316761684323 0.471626453088116 no 1555 0.476264318137649 2213 17646060
SGTC_645 0845-0943 5.41 µM 0.0590161618124384 0.471860386477243 no 1556 0.476469617641798 2244 1885106
SGTC_25 0118-0223 35.662 µM 0.0589288632609352 0.4719000023336 no 1557 0.476504384217552 2283 5333628
SGTC_1867 st057372 64 µM 0.0587946504971086 0.471960908280015 no 1558 0.476557834688228 2297 688837
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.0559313967747578 0.473260410875138 no 1559 0.477698229480453 2269 7104
SGTC_1714 st033236 13.627 µM 0.05526895813744 0.473561103143834 no 1560 0.477962096084925 2279 2916566
SGTC_34 0469-0683 81.75 µM 0.0547930146840335 0.473777151357175 no 1561 0.47815168275929 2256 3690923
SGTC_676 falcarinol 140 µM 0.054627341330023 0.473852358390172 no 1562 0.478217678022291 2312 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_355 1311-2252 105 µM 0.0545291275912215 0.473896942728195 no 1563 0.478256801321861 2223 5338538
SGTC_3284 9108171 64.8615 µM 0.0540554090360902 0.474111992867144 no 1564 0.478445509353048 2237 8687505
SGTC_1734 st037168 69.4 µM 0.0539458861049697 0.474161713172596 no 1565 0.478489139020944 2120 708907
SGTC_736 0958-0254 92.6 µM 0.0525064482288598 0.474815214270302 no 1566 0.479062578740228 2262 6812352
SGTC_719 2810-4230 27.3 µM 0.0523179018897093 0.474900818881051 no 1567 0.479137694602739 2320 721079
SGTC_2257 7960413 200 µM 0.0519410924020116 0.475071902995096 no 1568 0.479287815723606 2249 2974689 YIL048W NEO1
SGTC_2937 9044753 11.33 µM 0.0516480126396631 0.475204974192111 no 1569 0.479404580905275 2320 6465530 YGL099W LSG1
SGTC_1215 3852-0577 11.2 µM 0.0515240382008879 0.475261264913326 no 1570 0.479453973786675 2299 2884876
SGTC_1150 3909-7983 10.9 µM 0.0509796909214549 0.475508432183551 no 1571 0.479670851899169 2272 23965914
SGTC_16 erodoxin 22.806 µM 0.0508446163273512 0.475569765851355 no 1572 0.479724669072176 2308 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2032 5185112 25.99 µM 0.0507504337847886 0.475612531902937 no 1573 0.479762194024742 2298 5718189
SGTC_1020 4335-0961 93.3 µM 0.0490573816513844 0.476381354037037 no 1574 0.480436783501193 2238 669075
SGTC_1743 st037606 46.3785 µM 0.0488387868067384 0.476480625350487 no 1575 0.480523885819429 2287 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1244 0416-0015 52.5 µM 0.0482179081176891 0.476762595306392 no 1576 0.480771289086531 2286 96201
SGTC_1397 3532-0190 20.1 µM 0.0469577777775241 0.477334914859629 no 1577 0.481273439417305 2285 5322280
SGTC_2110 5483698 200 µM 0.0468917024383203 0.477364925919484 no 1578 0.481299770658046 2271 2848765 YHR062C RPP1
SGTC_958 1222-0007 33 µM 0.0462221591086988 0.477669036071447 no 1579 0.481566590466713 2302 7312461
SGTC_641 4092-0595 30 µM 0.0456622693737539 0.477923350966973 no 1580 0.481789718550358 2293 786260
SGTC_1314 1222-0010 41.1 µM 0.0445629728491334 0.478422702986719 no 1581 0.482227828354517 2283 3526027
SGTC_1292 0kpi-0043 232 µM 0.0431027812381702 0.479086042722769 no 1582 0.482809801127051 2285 3333905
SGTC_2930 9013230 14.89 µM 0.0428732619356893 0.479190314678684 no 1583 0.482901281515209 2310 2995857
SGTC_1675 st018485 24.5 µM 0.0420572382327442 0.479561050483826 no 1584 0.483226534466945 2209 3323024
SGTC_1600 coumarin 106 71.1 µM 0.0416922723064739 0.479726867508002 no 1585 0.483372007206236 2293 100336 A hepatotoxic, DNA x-linker.
SGTC_2386 9075165 157.42 µM 0.0414389169716591 0.479841977928598 no 1586 0.48347299408585 2298 16452277
SGTC_107 0358-0022 2.6945 µM 0.0407128217105565 0.480171884074404 no 1587 0.483762419912191 2294 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_501 nsc-95397 161 µM 0.0404328756079296 0.480299083063053 no 1588 0.483874010362942 2315 262093
SGTC_2771 fluoxetine 41.05 µM 0.040232715587185 0.480390030915139 no 1589 0.483953797735099 2318 3386 A selective serotonin reuptake inhibitor.
SGTC_761 k216-0224 480 µM 0.040222433861897 0.480394702709 no 1590 0.483957896232477 2353 1340404
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.0396261987694107 0.480665623640069 no 1591 0.484195570120639 2269 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_891 0929-0073 133 µM 0.0391678771842825 0.480873884669697 no 1592 0.48437827213401 2312 5603632
SGTC_3291 9121177 71.43 µM 0.0390033855048885 0.480948630857591 no 1593 0.484443844713311 2302 17015612
SGTC_2331 7980721 200 µM 0.0384982906213397 0.481178153736362 no 1594 0.484645197180871 2302 2981221
SGTC_1463 k081-0032 34.1 µM 0.0381330873799389 0.48134411159374 no 1595 0.484790785286396 2309 977755
SGTC_858 0438-0351 2.77 µM 0.0381051882959451 0.481356789796881 no 1596 0.484801907327105 2302 2799119
SGTC_2251 lansoprazole 556 µM 0.0376123125492941 0.481580770815512 no 1597 0.484998395437244 2243 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_319 1348-1596 45.5 µM 0.0364862539362187 0.482092515314786 no 1598 0.48544731959102 2329 5380505
SGTC_1909 st060837 51.5 µM 0.0363023583514155 0.482176090658205 no 1599 0.485520634744163 2293 678937
SGTC_2738 aclarubicin 5.55 µM 0.0360640812929923 0.48228438200813 no 1600 0.485615631330663 2327 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_1247 0448-0043 5.84 µM 0.0348002395778035 0.482858790168519 no 1601 0.486119514796556 2303 3089013 YGL099W LSG1
SGTC_820 1582-0060 59.9 µM 0.0345855688529333 0.482956360239137 no 1602 0.486205104501623 2305 3848840
SGTC_909 3448-9333 149 µM 0.0316882917527498 0.484273300199594 no 1603 0.487360316013408 2339 3344074
SGTC_838 0109-0203 71.4 µM 0.0316304904058684 0.484299575249117 no 1604 0.48738336386102 2344 759422
SGTC_530 4358-1714 28 µM 0.0312602211213874 0.484467892035908 no 1605 0.487531006919347 2282 1564641
SGTC_384 k007-0144 5.16 µM 0.0297086094383134 0.485173252486512 no 1606 0.488149722807448 2308 6824886
SGTC_2705 st078069 42.8 µM 0.0295270323008478 0.485255800268179 no 1607 0.488222129839393 2315 1530061
SGTC_3202 9113761 49.47 µM 0.0294039608225134 0.485311750829677 no 1608 0.488271206946204 2332 4798415
SGTC_577 r071-0003 38.6 µM 0.0286819509533341 0.485639995606823 no 1609 0.488559125749237 2353 4568517 YMR134W ERG29
SGTC_822 1487-0950 154 µM 0.0286155778214184 0.485670171079286 no 1610 0.488585593933704 2364 1958375
SGTC_408 cantharidin 100 µM 0.0284889551774895 0.485727738246766 no 1611 0.488636088473414 2278 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3281 9140613 49.47 µM 0.0279914119016043 0.485953942024453 no 1612 0.488834500387131 2276 16013766
SGTC_2416 tofa 880 nM 0.0279361992481646 0.485979044263125 no 1613 0.488856518438539 2291 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1267 0828-0272 9.49 µM 0.0277118481653223 0.48608104526426 no 1614 0.488945986932053 2340 745334
SGTC_2539 epi(13)torulosol 80 µM 0.02763065078383 0.486117961799394 no 1615 0.488978367601299 2326 6708597
SGTC_925 2064-1272 59.6 µM 0.0268568198495316 0.486469791346064 no 1616 0.489286966925456 2315 6815817
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0267922250377266 0.486499160467676 no 1617 0.48931272725732 2335 688761
SGTC_503 tyrphostin 8 294 µM 0.0266895335938217 0.486545851016858 no 1618 0.489353680571155 2348 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_419 nsc-638432 893 µM 0.0248542363704755 0.487380333069094 no 1619 0.490085615015805 2321 368090
SGTC_2317 5986382 200 µM 0.0246405787267761 0.487477483647831 no 1620 0.490170825986195 2343 877883
SGTC_2908 7930301 100 µM 0.0238013982068952 0.487859067927186 no 1621 0.49050551237931 2366 2223178
SGTC_2186 6124449 200 µM 0.0237270069513582 0.487892894961202 no 1622 0.490535181817526 2352 3834182 YLR033W RSC58
SGTC_1637 st007924 17.4 µM 0.0235306404788518 0.487982186725063 no 1623 0.490613498839653 2364 683336
SGTC_1167 k781-0610 148 µM 0.0235138828621352 0.487989806776625 no 1624 0.490620182312252 2332 4525169
SGTC_2495 cafestol 54.53 µM 0.0233213799695344 0.488077342328379 no 1625 0.490696958800651 2307 16667697 An anti-infammatory.
SGTC_2865 9030313 51.95 µM 0.0229096312940403 0.488264575970101 no 1626 0.490861178875606 2364 42562754
SGTC_1953 st076800 12.1 µM 0.0218402471290405 0.488750866846105 no 1627 0.491287694634357 2300 297591
SGTC_709 3807-1509 243 µM 0.0207337970907596 0.489254030621463 no 1628 0.491729004315004 2368 1886677 YPL242C IQG1
SGTC_1100 amiodarone 5.07 µM 0.0200149079477171 0.489580958327126 no 1629 0.49201574006269 2385 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_101 0490-5701 117.494 µM 0.0194881786598736 0.489820502355078 no 1630 0.49222583365829 2362 4661669
SGTC_1187 1391-0724 117 µM 0.019399582544763 0.489860794136857 no 1631 0.492261171713812 2328 6997986
SGTC_1738 st035555 74 µM 0.0189672875214236 0.490057394941938 no 1632 0.492433600744666 2351 5331140
SGTC_778 3456-2434 196 µM 0.0187806616141493 0.490142270144223 no 1633 0.492508040449694 2372 5539063
SGTC_150 3970-0969 77.2 µM 0.0186077767737259 0.490220896474098 no 1634 0.492576999471353 2312 6615640
SGTC_1772 st048439 82.2 µM 0.0179842458271602 0.490504475368124 no 1635 0.492825710694267 2345 2927068 YDL195W SEC31
SGTC_3023 9089636 49.47 µM 0.0174940642061998 0.49072741100323 no 1636 0.493021234100146 2381 17249241
SGTC_38 0929-0051 58.268 µM 0.0174121956730323 0.490764645268975 no 1637 0.493053889945396 2375 1379719
SGTC_2114 5491910 81.25 µM 0.017158265886362 0.490880134463462 no 1638 0.493155178140747 2363 2849228
SGTC_2710 st078562 53.7235 µM 0.0168688583695588 0.491011760130603 no 1639 0.493270618326121 2376 17250908
SGTC_51 1013-0126 23.419 µM 0.0137349095036999 0.49243717363342 no 1640 0.494520736157151 2388 1627850
SGTC_815 1582-0027 36.9 µM 0.0133834843382461 0.492597018647811 no 1641 0.494660921626057 2365 3128206
SGTC_1526 st051518 75 µM 0.0132504078314516 0.492657548535171 no 1642 0.49471400676381 2341 673993
SGTC_2488 5268135 45.7 µM 0.0123727859870248 0.493056739252292 no 1643 0.495064098479838 2376 1270356 YLR208W SEC13
SGTC_1139 k015-0024 46.9 µM 0.0123659384955184 0.493059853896157 no 1644 0.495066830024742 2378 2766652
SGTC_416 estradiol valerate 100 µM 0.011892126850739 0.493275372454391 no 1645 0.495255839617587 2368 13791 A steroid.
SGTC_2089 5281248 129.67 µM 0.0117238373405858 0.493351921307445 no 1646 0.495322972738159 2377 2737878
SGTC_1708 st033234 31.827 µM 0.011185028667952 0.493597007650871 no 1647 0.495537912195195 2367 674664
SGTC_2455 5377712 9.75 µM 0.0109562071396674 0.49370109177456 no 1648 0.49562919318349 2362 2243908
SGTC_1005 4092-0690 4.4 µM 0.0104456283975489 0.493933340430107 no 1649 0.495832872966999 2378 1529343
SGTC_424 splitomicin 100 mM 0.0100799673916465 0.494099671139888 no 1650 0.495978742919655 2344 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3305 9127027 53.8275 µM 0.00964987632270866 0.49429531090152 no 1651 0.496150316081486 2378 41905295
SGTC_668 1682-0499 62.6 µM 0.00949811105281098 0.494364346194909 no 1652 0.496210858889506 2385 682214
SGTC_887 0885-0007 9.62 µM 0.00870034730067335 0.494727237313659 no 1653 0.496529107396446 2378 5719458
SGTC_1693 xanthone 101.9 µM 0.00747857894401199 0.495283010310543 no 1654 0.497016506472646 2384 7020 An insecticide.
SGTC_202 3594-0513 34.79 µM 0.00708433560763178 0.495462350567638 no 1655 0.497173782637859 2383 708429
SGTC_2224 6650123 117.647 µM 0.00608321844343055 0.495917760170877 no 1656 0.497573161929752 2397 2908370
SGTC_2337 9009472 200 µM 0.00585200583358687 0.496022939889503 no 1657 0.497665400772937 2386 5742383
SGTC_3312 9133330 71.43 µM 0.00497704677282846 0.496420965379184 no 1658 0.498014453808112 2389 17617324
SGTC_483 fpl-64176 144 µM 0.00311041396751686 0.497270122158356 no 1659 0.498759126359648 2400 3423
SGTC_2132 5317594 122.667 µM 0.00263335815036585 0.49748714350834 no 1660 0.498949443308574 2402 794577
SGTC_2269 7935389 174.42 µM 0.00249817359654315 0.497548641553541 no 1661 0.499003373965192 2399 97605
SGTC_2825 7998094 58.44 µM 0.00222059683920158 0.497674916722969 no 1662 0.499114110761178 2396 2987815
SGTC_3339 9145883 14.936 µM 0.00213100002646705 0.497715676139536 no 1663 0.499149854633347 2396 2030670
SGTC_508 roscovitine 141 µM 0.00105756051042801 0.498204007390839 no 1664 0.499578094476953 2401 160355 A CDKinase inhibitor.
SGTC_1841 st054148 70 µM 0.000602177020796689 0.498411172214005 no 1665 0.499759766140637 2403 675442
SGTC_128 0906-2981 13.371 µM 0.000131514108140369 0.498625288461143 no 1666 0.499947533461945 2405 6740226
SGTC_497 capsazepine 133 µM 0 0.498685117568315 no 1667 0.5 2405 2733484 A calcium channel blocker.
SGTC_545 4218-0007 221 µM -0.00022973782079088 0.498789631206594 no 1668 0.499908347870685 2408 2840508
SGTC_1103 duloxetine 36.1 µM -0.000440263244494521 0.498885404704852 no 1669 0.499824360382939 2407 60835 A selective serotonin reuptake inhibitor.
SGTC_53 0973-0023 39.979 µM -0.00109295815607622 0.499182333002939 no 1670 0.499563972867642 2408 674768
SGTC_2927 9011802 47.9 µM -0.00110670213951598 0.499188585512487 no 1671 0.499558489814863 2406 43912568
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.00120036697967914 0.499231196185139 no 1672 0.499521122974809 2409 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_2157 5649910 96.377 µM -0.00120560754859281 0.49923358026214 no 1673 0.499519032291809 2407 2858091
SGTC_2622 2-methoxyxanthone 59.94 µM -0.00138777074686167 0.499316451260404 no 1674 0.499446359751283 2413 71034 A hepatoprotective.
SGTC_2328 6201408 200 µM -0.00157040518315348 0.499399536667282 no 1675 0.499373499232588 2409 2890418
SGTC_66 0109-0187 42.4 µM -0.00180213162072406 0.499504955407045 no 1676 0.499281053890796 2408 759417
SGTC_639 0833-0042 114 µM -0.00184825671104851 0.49952593898559 no 1677 0.49926265267273 2411 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_322 k048-0136 19.3 µM -0.00226132314358293 0.499713854375035 no 1678 0.499097863357233 2417 6823282
SGTC_3174 9107204 49.47 µM -0.0035193053475137 0.499713854375035 no 1679 0.498596003197437 2414 3938802
SGTC_1365 1672-3266 55.4 µM -0.00583803280758804 0.498659002883428 no 1680 0.497670975108571 2420 6415873
SGTC_1783 st039459 87.517 µM -0.00585694178600225 0.498650400709043 no 1681 0.497663431646571 2425 729761
SGTC_2806 7952793 58.44 µM -0.00622553087164543 0.498482720305657 no 1682 0.497516388560352 2424 2972490
SGTC_3235 9132602 49.47 µM -0.0067057372141318 0.498264262824165 no 1683 0.497324817953149 2460 4912240
SGTC_3091 9116372 49.47 µM -0.00687137852059592 0.498188908704367 no 1684 0.49725873815534 2475 17169793
SGTC_252 miconazole 1.30953 nM -0.00690303158953312 0.498174508987321 no 1685 0.497246110707324 2418 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_644 1498-1197 63.3 µM -0.00720772904922641 0.49803589515258 no 1686 0.497124557033802 2421 6741615
SGTC_2892 9047358 58.44 µM -0.00762432377103287 0.497846377084231 no 1687 0.496958364356832 2426 6466771
SGTC_2042 p-Dimethylaminoacetophenone 200 µM -0.00786276295271712 0.497737906091198 no 1688 0.496863243738056 2431 75037 A free radical scavenger.
SGTC_2515 chrysin 20.77 µM -0.00810399426058086 0.497628165071523 no 1689 0.496767009436989 2424 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1824 st053723 68.6 µM -0.00865903964124344 0.497375664353992 no 1690 0.496545586147554 2427 675225
SGTC_1317 1273-0028 910 nM -0.00896799805202577 0.497235113736126 no 1691 0.496422334362173 2426 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.0100250316536572 0.496754253252036 no 1692 0.496000658000924 2425 688798
SGTC_1842 st055362 61.2 µM -0.0106458573020503 0.496471832480218 no 1693 0.495752997633068 2436 676032
SGTC_2362 9071156 126 µM -0.0117287534354432 0.495979214813733 no 1694 0.495321011634903 2437 653133
SGTC_3007 9078383 71.4286 µM -0.0118273241613826 0.495934374535834 no 1695 0.495281690332195 2437 6496995
SGTC_789 1309-1135 70.6 µM -0.0120171090089821 0.495848040678405 no 1696 0.495205982513139 2427 3092424
SGTC_185 k048-0037 25.491 µM -0.0120676413458191 0.495825053356553 no 1697 0.495185824489148 2423 6827589
SGTC_1268 0828-0275 2.46 µM -0.0120751525890604 0.49582163646913 no 1698 0.49518282815496 2453 745337
SGTC_2988 9073640 71.4286 µM -0.0124423728880285 0.49565458721562 no 1699 0.495036339459677 2445 9102229
SGTC_167 3672-0051 66.205 µM -0.0125756794784488 0.495593945966153 no 1700 0.494983161985196 2425 3237971
SGTC_215 1287-0124 461.5 µM -0.0129933369082441 0.495403954011684 no 1701 0.494816554394971 2475 5560863
SGTC_816 0325-0417 81.3 µM -0.0146067496870947 0.494670024301988 no 1702 0.494172957178176 2443 68101
SGTC_500 h-89 112 µM -0.0148956977372361 0.494538585773728 no 1703 0.49405769612554 2434 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2448 5185112 27.17 µM -0.0168772772162052 0.493637209013205 no 1704 0.493267260170309 2455 5718189
SGTC_3110 9122132 49.47 µM -0.0169602619393394 0.493599461771241 no 1705 0.49323415879352 2518 918317
SGTC_123 0083-0120 66.675 µM -0.0170174621511843 0.493573443157356 no 1706 0.493211342503443 2441 16001701
SGTC_2974 9094440 9.66 µM -0.0173122587197654 0.49343934971771 no 1707 0.49309375301266 2578 25236134
SGTC_1205 4161-2785 76 µM -0.0176477677803519 0.493286738382948 no 1708 0.4929599247108 2495 3498106
SGTC_2587 piperic acid 92.2 µM -0.0177885925702368 0.49322268240389 no 1709 0.492903752565895 2444 5370536
SGTC_2379 9035213 200 µM -0.0181481533328908 0.49305913233207 no 1710 0.49276033173054 2435 646551
SGTC_2066 5222451 176 µM -0.0184503836916345 0.492921660511164 no 1711 0.492639779448428 2438 2281147
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.0197972640692148 0.492309031983147 no 1712 0.492102550206662 2444 2724278 An inhibitor of dopamine biosynthesis.
SGTC_2504 purpurogallin 52.29 µM -0.0198630048841195 0.492279130226662 no 1713 0.492076328572182 2467 5281571 An antioxidant.
SGTC_754 3474-0146 171 µM -0.020080829894979 0.492180054332975 no 1714 0.491989446295213 2444 24762078
SGTC_2160 5660466 132.927 µM -0.0200814478589759 0.492179773257877 no 1715 0.491989199812949 2436 2859134
SGTC_2342 7990637 118.86 µM -0.0203814277527737 0.492043330692111 no 1716 0.491869549640068 2455 2033102 YER133W GLC7
SGTC_2977 9011197 71.43 µM -0.0205989294619432 0.491944403005624 no 1717 0.491782797225692 2469 2704722
SGTC_812 4251-0442 148 µM -0.0210046642208925 0.491759861412193 no 1718 0.491620967493672 2429 5723007
SGTC_993 3909-8757 62.7 µM -0.0211698016836766 0.491684751932772 no 1719 0.491555101823682 2456 4288324 YLR208W SEC13
SGTC_2445 5742597 35.57 µM -0.0214989567327671 0.49153504320952 no 1720 0.491423817839114 2456 1774255
SGTC_2286 7945697 125 µM -0.0217103035159026 0.491438917536596 no 1721 0.491339522346831 2469 1245733
SGTC_1237 0330-0133 46.1 µM -0.0219457123575418 0.491331848438019 no 1722 0.491245630177624 2447 X1237 YHR072W ERG7
SGTC_1047 2043-3044 82 µM -0.0230732044093766 0.490819049145573 no 1723 0.49079593988915 2448 669592
SGTC_2248 tofa 1.1 µM -0.0238749824988626 0.490454398340862 no 1724 0.49047616483377 2448 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2921 7974240 10.71 µM -0.0241829721964713 0.490314325912626 no 1725 0.490353330188926 2454 2979074 YDR527W RBA50
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -0.0243080200680375 0.490257455002834 no 1726 0.490303457966616 2451 688664
SGTC_67 0335-0847 266 µM -0.0249876568534129 0.489948364372336 no 1727 0.490032404469995 2489 4552207 YOR254C SEC63
SGTC_162 k030-0015 37.8 µM -0.0253657055634542 0.48977643496965 no 1728 0.48988163264849 2469 1809920 YMR134W ERG29
SGTC_289 k017-0060 526 µM -0.0262122010867803 0.489391471753362 no 1729 0.489544042083506 2471 5512909
SGTC_743 1275-0778 158 µM -0.0263034187556699 0.48934998901386 no 1730 0.489507664041672 2477 2849257 YMR203W TOM40
SGTC_2706 st078239 82.5 µM -0.0267040143283005 0.489167812939569 no 1731 0.489347905652231 2447 15434492
SGTC_2681 menadione 3.18 µM -0.0271506264975463 0.488964712882221 no 1732 0.48916979775945 2473 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2954 9074818 52.69 µM -0.0279509683475206 0.488600758932614 no 1733 0.488850628720286 2484 16648742
SGTC_1033 k072-0102 21.3 µM -0.0281339764715294 0.488517537655232 no 1734 0.488777647743106 2447 5965931
SGTC_1514 1189-1591 158 µM -0.0281503963405246 0.488510070893761 no 1735 0.488771099756585 2460 767698 YMR146C TIF34
SGTC_773 4358-1457 44.6 µM -0.0290122285352781 0.488118167549512 no 1736 0.488427418869774 2454 1186886
SGTC_3137 9097352 49.47 µM -0.031612580110976 0.486935773536334 no 1737 0.487390505463493 2492 44120435
SGTC_2588 indole-3-carbinol 100 µM -0.0317235948237802 0.486885297024323 no 1738 0.487346239203001 2487 3712 Induces cell cycle arrest.
SGTC_2772 vinpocetine 57.06 µM -0.0318810431548396 0.486813708292042 no 1739 0.487283458162836 2476 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1844 rapamycin 4 nM -0.0319306689054425 0.486791144504285 no 1740 0.487263670427085 2446 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_3242 9133940 49.47 µM -0.0322200698959397 0.486659560789553 no 1741 0.487148275512494 2557 17248444
SGTC_221 trifluoperazine 10.304 µM -0.0330476712705743 0.486283278285464 no 1742 0.486818286103367 2449 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_2999 9069765 71.4286 µM -0.0334470228059645 0.48610171092422 no 1743 0.486659055921952 2484 2097066
SGTC_335 4077-0256 27.6 µM -0.0336051347164249 0.486029825272842 no 1744 0.486596013835446 2538 3121989
SGTC_2560 caryophyllene 100 µM -0.0340721561658026 0.485817496419943 no 1745 0.486409805874728 2477 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2753 fluvastatin 17.09 µM -0.0344060938226864 0.48566567587727 no 1746 0.486276662091281 2512 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_879 0831-1030 162 µM -0.0347547152717895 0.485507181750828 no 1747 0.486137665387365 2471 1549252
SGTC_330 1488-0319 80.1 µM -0.0355700204853525 0.485136527688224 no 1748 0.485812606687374 2515 6846614
SGTC_2540 epiandrosterone 100 µM -0.0356930201924862 0.485080610667352 no 1749 0.485763568043494 2478 441302 A steroid.
SGTC_1806 st050005 60.3 µM -0.0370693961165115 0.484454915284573 no 1750 0.485214836805373 2483 5194765
SGTC_1788 fluconazole 20 µM -0.0380168545947879 0.484024226328585 no 1751 0.484837121859415 2545 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3295 9122362 53.5725 µM -0.0382887634334748 0.483900627357046 no 1752 0.484728724849639 2504 4730473
SGTC_2912 7964298 10.93 µM -0.0385381602599911 0.483787262813072 no 1753 0.484629303291198 2510 2975850
SGTC_3180 9109287 49.47 µM -0.039403988343585 0.483393706665912 no 1754 0.484284150071207 2523 18891271
SGTC_452 diindolylmethane 8 µM -0.0394202864984025 0.483386298606677 no 1755 0.484277653096048 2512 3071 Inhibits expression of several cancer promoting factors.
SGTC_3348 9149464 3.537 µM -0.0402718779499386 0.482999229704961 no 1756 0.483938186864657 2467 1951442
SGTC_2821 7996764 71.43 µM -0.0405450414749601 0.482875073655784 no 1757 0.483829299319866 2516 2987135
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.0406844664797155 0.482811703983359 no 1758 0.483773722647956 2484 16623 A steroid.
SGTC_438 sphingosine 6.67 µM -0.0406867952100253 0.482810645562284 no 1759 0.483772794387578 2493 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_1264 0783-0040 158 µM -0.0418642998891787 0.482275478714143 no 1760 0.483303437997516 2479 2855798
SGTC_39 0986-0283 58.349 µM -0.0426716918010289 0.48190854367894 no 1761 0.482981622839018 2503 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_3029 9088683 49.47 µM -0.0437094705903205 0.481436927376405 no 1762 0.482567994996912 2560 25236615
SGTC_3340 9146634 11.102 µM -0.0437479824983147 0.481419426219836 no 1763 0.482552645651054 2505 4907387
SGTC_964 1287-0107 19.4 µM -0.0439084877433589 0.481346487414562 no 1764 0.482488674793428 2506 51516812 YPR165W RHO1
SGTC_2880 9042983 58.44 µM -0.0440701266029171 0.481273034089043 no 1765 0.482424252578825 2536 6464714
SGTC_2764 methyldopa 94.69 µM -0.044411600004422 0.481117860892303 no 1766 0.482288157653352 2502 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_73 0327-0325 16.231 µM -0.0459197192529545 0.480432572112578 no 1767 0.481687118531787 2560 53298
SGTC_2319 6033012 152.6 µM -0.047386514334791 0.479766116470595 no 1768 0.481102588474281 2506 847246
SGTC_3211 9128781 49.47 µM -0.0485533541043446 0.479235989364503 no 1769 0.480637622060474 2595 17194361
SGTC_740 k014-0057 261 µM -0.0488347818300091 0.479108134541365 no 1770 0.480525481669766 2554 4012779
SGTC_2499 avocadenofuran 51.48 µM -0.0488779491034687 0.47908852350028 no 1771 0.480508280960079 2502 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_2412 st077135 33.4 µM -0.0490097937285309 0.479028626346424 no 1772 0.480455745526817 2739 13258915
SGTC_248 streptozotocin 5.23457 mM -0.0502648835728574 0.478458461596136 no 1773 0.479955653614213 2577 5300 DNA alkylating agent.
SGTC_1413 3910-0535 34.4 µM -0.0513377507705901 0.477971112220246 no 1774 0.479528193493237 2560 2876951
SGTC_745 0469-0705 296 µM -0.0514625549407983 0.477914422114561 no 1775 0.479478469561117 2517 3486736
SGTC_618 k072-0232 33.2 µM -0.0514707344395799 0.47791070673627 no 1776 0.479475210732098 2532 5872756 YGL099W LSG1
SGTC_1991 st073000 8.92 µM -0.0516387156664868 0.477834404954975 no 1777 0.47940828491829 2633 4301969 YIL048W NEO1
SGTC_2354 9060492 162 µM -0.0518584106440241 0.477734614565374 no 1778 0.479320756578304 2519 6471895
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.051883755264225 0.477723102559741 no 1779 0.47931065913101 2667 6710655
SGTC_656 4090-1979 187 µM -0.0533857643396444 0.477040895168062 no 1780 0.478712273724638 2495 22330961
SGTC_2703 st077852 53.4 µM -0.0543228234109739 0.476615320091969 no 1781 0.478338982972956 2557 6281836
SGTC_2802 7925815 54.55 µM -0.0554894033367267 0.476085543069023 no 1782 0.477874285928337 2520 1262923
SGTC_2119 5528445 120.635 µM -0.0578682359416343 0.475005379713326 no 1783 0.476926792376334 2579 791935
SGTC_149 3970-0822 46.1 µM -0.0583374797322399 0.474792330277099 no 1784 0.476739906913797 2512 3114250 YBL034C STU1
SGTC_1445 4239-0156 97.7 µM -0.0594383528207951 0.474292532368883 no 1785 0.476301482955316 2625 4008346
SGTC_265 mycophenolic acid 32.932 µM -0.0595043740254294 0.47426255992855 no 1786 0.476275190842065 2644 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_573 3702-0553 84.7 µM -0.0602744068603455 0.473912989663603 no 1787 0.475968542621473 2513 1222756
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.0605579351618799 0.473784281933123 no 1788 0.475855637441201 2549 688788
SGTC_1727 st034309 9.9045 µM -0.0622233306698492 0.47302833098466 no 1789 0.475192491649304 2729 870305
SGTC_2191 5911152 200 µM -0.0627606731460998 0.472784442818099 no 1790 0.47497854119222 2519 2875902
SGTC_2512 diallyl trisulfide 49.23 µM -0.0629138928738644 0.47271490155199 no 1791 0.474917535924038 2494 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_3351 9150312 21.596 µM -0.0643904556570098 0.472044782448035 no 1792 0.474329664769732 2513 4904905
SGTC_142 0335-0849 62.6745 µM -0.0651243210907432 0.471711756340027 no 1793 0.474037508051726 2533 3889043 YPR107C YTH1
SGTC_2686 alizarin 95.37 µM -0.0651772114698747 0.471687755593268 no 1794 0.474016452576988 2561 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_949 1165-0505 146 µM -0.0652761835149786 0.471642844053265 no 1795 0.473977052347419 2523 6244267
SGTC_204 PMA1.184 62.41 µM -0.0656205570015274 0.471486577047698 no 1796 0.473839961133075 2499 2252213 YGL008C PMA1
SGTC_3075 9116269 49.47 µM -0.0660419623845411 0.471295361108202 no 1797 0.473672208603116 2590 17015205 YNL244C SUI1
SGTC_2404 5161160 200 µM -0.0664731228605625 0.471099725569062 no 1798 0.473500577610042 2519 2831543
SGTC_2991 9074669 71.4286 µM -0.0667673200195457 0.470966240014647 no 1799 0.473383470089988 2576 17333109
SGTC_23 0213-0011 39.996 µM -0.0669625074617348 0.470877679762254 no 1800 0.473305775444238 2569 627608
SGTC_3127 9126946 49.47 µM -0.0693788811652647 0.469781445732219 no 1801 0.472344019397761 2608 27243249
SGTC_1671 st016596 74.5 µM -0.0697480874031874 0.469613968240782 no 1802 0.47219708336802 2559 2829167
SGTC_1653 st012112 65 µM -0.0699999522139235 0.469499721664699 no 1803 0.472096848836716 2579 720429
SGTC_2596 sinensetin 100 µM -0.0702245391014227 0.469397850547745 no 1804 0.472007471579144 2572 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2541 muurolladie-3-one 83.07 µM -0.0702459116167934 0.469388156221347 no 1805 0.47199896618352 2676 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_1212 0520-0165 585 µM -0.070471977283488 0.469285616555316 no 1806 0.471909001985464 2707 5403258
SGTC_2667 digitoxin 100 µM -0.070858811179314 0.469110159795368 no 1807 0.471755062426247 2549 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1545 lovastatin 49.4 µM -0.0714405434154035 0.46884631404272 no 1808 0.471523571522313 2569 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_823 0417-1665 178 µM -0.0720239441723622 0.468581725269888 no 1809 0.471291426319469 2599 3429856
SGTC_2959 9079155 11 µM -0.0726375084201254 0.468303471472798 no 1810 0.471047289069699 2639 16189457
SGTC_441 propafenone 146 µM -0.0737144315305306 0.467815120132594 no 1811 0.470618807665498 2528 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2544 sphondin 68.51 µM -0.0741152267090835 0.467633384236376 no 1812 0.470459349711002 2683 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_660 4031-1742 102 µM -0.0743441011494973 0.467529606816168 no 1813 0.470368293228467 2536 6738706
SGTC_1383 3049-0032 20.7 µM -0.0744355973082558 0.467488120776642 no 1814 0.470331892400081 2607 712864
SGTC_3003 9075612 71.4286 µM -0.0744503785133096 0.467481418739803 no 1815 0.470326011869266 2607 6501993
SGTC_2618 avocadyne 43.43 µM -0.0759212566854343 0.466814545256967 no 1816 0.469740872638057 2561 3015189
SGTC_1559 coumarin 343 70.1 µM -0.0760733632368328 0.46674558777446 no 1817 0.469680365887299 2609 108770 A hepatotoxic, DNA x-linker.
SGTC_3082 9117008 49.47 µM -0.0783143910207886 0.465729734942544 no 1818 0.468788985121115 2589 41448529
SGTC_1079 idarubicin 2.36 µM -0.0793178125271822 0.465274958208729 no 1819 0.468389919294809 2537 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1343 1487-0095 224 µM -0.0796638924548794 0.465118116269099 no 1820 0.468252288896739 2537 4560101 YGL055W OLE1
SGTC_2340 7987427 183.45 µM -0.0799748888116832 0.464977178675407 no 1821 0.468128613904683 2616 2239331
SGTC_3109 9122853 49.47 µM -0.0816749921458024 0.464206802518387 no 1822 0.46745258263992 2610 1234709
SGTC_104 0074-0074 590.992 µM -0.0819806838018892 0.464068297107646 no 1823 0.467331036918562 2537 3943124
SGTC_1739 st037196 92.5 µM -0.0836034431153109 0.463333116642177 no 1824 0.466685864656489 2577 612214
SGTC_1989 st071868 50.2 µM -0.0847673683840969 0.462805884894111 no 1825 0.466223168197185 2551 16414057
SGTC_2511 berberine 10.47 µM -0.0848941210000712 0.462748472762177 no 1826 0.466172782839053 2575 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3076 9116187 49.47 µM -0.0852853576244844 0.462571268469201 no 1827 0.466017266020594 2614 27241210
SGTC_430 0958-0115 16.4 µM -0.0859918899762422 0.46225127492587 no 1828 0.465736432103601 2593 6833180
SGTC_1937 st074714 47.2 µM -0.0863049223803146 0.462109508114136 no 1829 0.465612012792602 2548 17250970
SGTC_2869 9037858 32.47 µM -0.0871197596376425 0.461740505421441 no 1830 0.465288159590452 2542 27187042
SGTC_3128 9127691 49.47 µM -0.0879107327704321 0.461382341200047 no 1831 0.464973813058342 2715 41316314
SGTC_643 k048-0106 28.4 µM -0.0879368088624726 0.461370534095275 no 1832 0.464963450335211 2669 6763920
SGTC_1895 st058434 18.3 µM -0.0879544389408159 0.461362551316309 no 1833 0.464956444098644 2565 5393175
SGTC_1066 ketoconazole 628 nM -0.0879955023347619 0.461343958152574 no 1834 0.464940125446852 2658 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2666 tannic acid 100 µM -0.0884674327061569 0.461130278075739 no 1835 0.46475258387861 2588 16134267 A thiamine antagonist.
SGTC_258 haloperidol 50.781 µM -0.0891066417087748 0.460840875681966 no 1836 0.464498579537091 2567 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1324 1418-0026 34.4 µM -0.0893671433937227 0.460722939272591 no 1837 0.464395067367975 2662 1372513
SGTC_462 ag-879 158 µM -0.0895470387996555 0.46064149759952 no 1838 0.464323586074644 2564 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_1612 st002233 45.4 µM -0.0905957498527926 0.460166761457489 no 1839 0.463906904585919 2570 1035021
SGTC_256 clotrimazole 625 nM -0.0907588528214663 0.460092932216055 no 1840 0.463842102876027 2552 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2446 5162541 200 µM -0.0908271191142813 0.460062031601194 no 1841 0.463814980585687 2556 1549321
SGTC_763 3453-1109 128 µM -0.0920830883014092 0.459493562639382 no 1842 0.463316012469743 2566 1560353
SGTC_1201 1889-3372 45.9 µM -0.0922978272606212 0.459396377084266 no 1843 0.463230707298922 2618 5392199
SGTC_1004 4084-0029 199 µM -0.0944070499802313 0.458441924776521 no 1844 0.462392907872897 2624 716894 YLR208W SEC13
SGTC_1091 telmisartan 47.6 µM -0.0956672987791947 0.457871758824096 no 1845 0.461892406766714 2676 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_1086 cerivastatin 2.18 µM -0.0960876136914008 0.457681617772303 no 1846 0.461725494314372 2582 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2036 5160441 105 µM -0.0964870739845655 0.457500919858678 no 1847 0.461566869746335 2600 134534 YIL048W NEO1
SGTC_2859 9028643 45.46 µM -0.0968046697501975 0.45735726005132 no 1848 0.461440757715282 2681 17151580
SGTC_1970 st070122 35.8 µM -0.0968890701615518 0.45731908369391 no 1849 0.461407244358012 2691 102928
SGTC_870 0573-2213 57.6 µM -0.0979456190522645 0.456841214389029 no 1850 0.460987737672219 2566 3916321
SGTC_3116 9124943 49.47 µM -0.0981661432869267 0.456741480746038 no 1851 0.460900183161111 2587 41905195 YPL160W CDC60
SGTC_1829 berberine 14.4 µM -0.100489178510487 0.45569103839541 no 1852 0.459977986824179 2747 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1224 0823-0416 294 µM -0.100892797804508 0.455508559058785 no 1853 0.459817780227001 2679 3598164
SGTC_1089 terbinafine 2.25 µM -0.101808671124691 0.455094520674394 no 1854 0.45945427142732 2683 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2185 6113692 200 µM -0.103111461013367 0.454505653256982 no 1855 0.458937254468465 2680 874150
SGTC_15 0266-0086 27.098 µM -0.10330578351919 0.454417827068366 no 1856 0.45886014279813 2608 1712902 YIL048W NEO1
SGTC_342 k048-0088 23.3 µM -0.103638524416465 0.45426744634623 no 1857 0.458728107100877 2572 6820570
SGTC_803 4488-1585 147 µM -0.104587227947698 0.453838720199452 no 1858 0.458351674870221 2639 747204
SGTC_974 1326-0144 138 µM -0.104690180776924 0.453792198280182 no 1859 0.458310826874662 2604 5411856
SGTC_1571 st070080 73.4 µM -0.105182178749729 0.453569884938374 no 1860 0.458115625785814 2697 4315245
SGTC_444 curcumin 90.4 µM -0.105394637159942 0.453473888347127 no 1861 0.458031335645972 2685 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1661 st013063 9.66 µM -0.105497820170272 0.453427267415707 no 1862 0.457990399795298 2594 721395
SGTC_2291 7917025 104.35 µM -0.105715291066189 0.453329010166501 no 1863 0.457904123910692 2609 2964612
SGTC_1443 4112-3303 14 µM -0.106181053240024 0.453118580086867 no 1864 0.457719351640008 2591 704433
SGTC_228 caffeine 993.056 µM -0.10632452561203 0.453053762309873 no 1865 0.457662436628703 2687 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1940 st075990 51.1 µM -0.107389458959897 0.452572687205579 no 1866 0.457240008339074 2852 1084979
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.107396889486861 0.452569330768317 no 1867 0.457237061032876 2708 5393153
SGTC_551 k048-0028 34.9 µM -0.107596798317944 0.452479031386575 no 1868 0.457157768409906 2688 6836383
SGTC_953 1188-0045 9.7 µM -0.108601450049763 0.452025264678632 no 1869 0.456759305292718 2697 6144426
SGTC_1801 st050089 28.441 µM -0.110007021642844 0.451390521520428 no 1870 0.45620190312483 2585 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1773 st048542 73.5835 µM -0.110297255502371 0.451259470013511 no 1871 0.456086816888707 2593 3237138
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.110397551620083 0.451214183777319 no 1872 0.456047047392992 2604 6708561
SGTC_1449 4112-4002 201 µM -0.110685280999332 0.451084270204276 no 1873 0.45593295915756 2633 2059539
SGTC_2075 5212009 200 µM -0.111207505512003 0.45084849240991 no 1874 0.455725900007651 2665 780898
SGTC_493 zm226600 134 µM -0.113544601873021 0.449793536459622 no 1875 0.454799402255234 2773 5240098 A potassium channel opener. YCR052W RSC6
SGTC_698 k064-0052 127 µM -0.115348850238329 0.44897934819975 no 1876 0.454084309921597 2577 5088751
SGTC_1448 4255-0083 152 µM -0.11764866382004 0.447941842157321 no 1877 0.45317302225604 2782 5399660
SGTC_2929 9013348 24.6 µM -0.117954438302162 0.447803925953645 no 1878 0.453051879372583 2696 2995952
SGTC_1723 st034307 2.5525 µM -0.117998380772696 0.447784106705693 no 1879 0.453034470438271 2679 867466
SGTC_2163 5671233 125 µM -0.11878833793603 0.447427836848393 no 1880 0.452721524120299 2661 701023
SGTC_87 0100-0052 35.5 µM -0.118873622244146 0.447389376245906 no 1881 0.452687739977582 2637 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_147 4466-0538 29.23 µM -0.11916198307248 0.447259338038826 no 1882 0.452573512552633 2793 6742687 YHR072W ERG7
SGTC_48 0382-0018 55 µM -0.119353481750266 0.447172983585728 no 1883 0.452497656980471 2795 762596
SGTC_33 0986-0033 35.816 µM -0.119542155286353 0.447087905551808 no 1884 0.452422922185944 2622 2848082
SGTC_1133 3473-0247 50 µM -0.119687133046442 0.447022532786995 no 1885 0.452365496712888 2698 711311
SGTC_2273 7815444 169.05 µM -0.119769445970875 0.446985417228125 no 1886 0.452332893130527 2624 2824616
SGTC_2350 9023895 38.85 µM -0.120010166500696 0.446876877073149 no 1887 0.452237547232124 2729 2997209
SGTC_800 3448-7362 155 µM -0.120031774315392 0.446867134369704 no 1888 0.452228988825841 2623 15991913
SGTC_599 1935-0052 86.5 µM -0.120292890405156 0.44674940280608 no 1889 0.452125567926004 2622 9557311
SGTC_3156 9099931 49.47 µM -0.120760629580175 0.44653852112867 no 1890 0.451940317432141 2634 18111053
SGTC_2707 st078556 66.6 µM -0.123451169773741 0.445325778031579 no 1891 0.450874919650618 2682 17250899
SGTC_2044 5102272 200 µM -0.124116965742182 0.445025753431475 no 1892 0.450611332654165 2710 592666
SGTC_1923 st058458 19.1 µM -0.124872547332846 0.444685307298427 no 1893 0.450312226140593 2832 3534982
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.12553856934267 0.444385248293345 no 1894 0.450048596313136 2591 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_3273 9137859 49.47 µM -0.125768524763527 0.444281655214134 no 1895 0.449957578746717 2623 2377234
SGTC_1939 st074455 53.6 µM -0.126000942601213 0.444176956703536 no 1896 0.449865589217495 2807 1644229
SGTC_1282 0886-0010 32.4 µM -0.126364571585466 0.444013158621392 no 1897 0.449721672541803 2693 2836211 YNL267W PIK1
SGTC_1422 4031-0024 15.5 µM -0.126922640231892 0.443761793051604 no 1898 0.449500813621136 2612 782427
SGTC_2841 9004761 38.96 µM -0.128261826763468 0.443158688433741 no 1899 0.448970886681723 2654 2991039
SGTC_381 3461-2219 42.7 µM -0.128695825961211 0.442963264439748 no 1900 0.448799169172179 2699 2883159
SGTC_1414 3917-0015 5.4 µM -0.128891103685877 0.442875338033248 no 1901 0.448721908090217 2641 6618702
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.128950019204546 0.44284881108545 no 1902 0.448698598712846 2671 676296 Flavone; oxidizing agent.
SGTC_134 0269-0018 6.916 µM -0.129365852308915 0.442661587859969 no 1903 0.448534083250491 2729 4378915
SGTC_274 sirtinol 40.1 µM -0.129745424019739 0.442490702012586 no 1904 0.448383921557092 2678 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2688 kanamycin b 96.69 µM -0.12987437367858 0.442432650404707 no 1905 0.44833290969234 2717 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2194 5927483 104.545 µM -0.130526374466071 0.442139146329655 no 1906 0.44807499441453 2620 760979
SGTC_172 1112-0046 2.638 µM -0.130913373520069 0.441964950201363 no 1907 0.447921917597649 2694 2802135 YIL048W NEO1
SGTC_2206 7254556 146.969 µM -0.130983309083314 0.441933471981312 no 1908 0.447894255531388 2688 4398905
SGTC_1189 1431-2119 7.28 µM -0.131140973294078 0.441862508162697 no 1909 0.447831894514768 2628 3107275
SGTC_2314 7727897 200 µM -0.131426955184246 0.441733794005708 no 1910 0.447718783223611 2663 900724
SGTC_1341 1486-1360 280 µM -0.135908068485581 0.439717755532353 no 1911 0.445946978467166 2623 3976547
SGTC_1358 1509-0022 2.48 µM -0.136293516589083 0.439544415896363 no 1912 0.445794624535708 2686 3258434
SGTC_2521 angolensin 13.4 µM -0.136555329449425 0.439426682799417 no 1913 0.445691143783393 2778 821428 A flavenoid.
SGTC_515 4092-1064 102 µM -0.137284640150499 0.43909875160767 no 1914 0.445402905431992 2769 717353
SGTC_3227 9130768 49.47 µM -0.137462410754069 0.439018824202797 no 1915 0.445332651259742 2664 17720899
SGTC_2870 9038528 12.99 µM -0.138973075033432 0.438339715406565 no 1916 0.444735712782743 2789 6463316
SGTC_1155 4088-0394 48.2 µM -0.138985336465392 0.438334204103645 no 1917 0.444730868192929 2636 2326248
SGTC_1011 4112-3381 17.4 µM -0.13935458339848 0.43816823956137 no 1918 0.444584979648196 2832 2877139
SGTC_562 3772-2733 112 µM -0.139560643642222 0.438075626878554 no 1919 0.444503569020695 2726 2876874 YIL048W NEO1
SGTC_488 nitrendipine 139 µM -0.14125358963607 0.437314870136435 no 1920 0.443834806010528 2650 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2052 5265182 7.135 µM -0.142571141960206 0.436722963698388 no 1921 0.443314444995437 2783 1239884
SGTC_1523 st012844 44.7 µM -0.142584876421688 0.436716794276328 no 1922 0.443309021148485 2792 4274103
SGTC_2986 9022445 71.43 µM -0.143827491550229 0.436158684305758 no 1923 0.442818346729196 2796 6459286
SGTC_3349 9149703 23.001 µM -0.144148784472285 0.436014398968321 no 1924 0.44269149125913 2636 4910494
SGTC_2787 5284540 71.43 µM -0.144609605142156 0.435807469765115 no 1925 0.442509556574492 2742 736958
SGTC_636 0kpi-0074 126 µM -0.144696333083557 0.435768526982508 no 1926 0.44247531723247 2735 616434
SGTC_1803 st050068 52.4 µM -0.144951261106405 0.435654062214057 no 1927 0.442374676633955 2663 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_315 k915-0449 187 µM -0.145508482590646 0.435403883988586 no 1928 0.442154709444815 2694 20970215 YNL149C PGA2
SGTC_883 0850-0245 24.6 µM -0.146262558823407 0.435065364188211 no 1929 0.441857060838175 2872 6823229 YPR165W RHO1
SGTC_2872 9044037 25.97 µM -0.14696876826545 0.434748375889262 no 1930 0.441578335952166 2646 6465195
SGTC_1473 k844-0725 134 µM -0.147213858729673 0.434638374678669 no 1931 0.441481611046897 2681 54682906
SGTC_714 4296-0578 26.1 µM -0.147740051756873 0.434402226452942 no 1932 0.441273960864881 2688 1589775
SGTC_1134 3477-0009 42.5 µM -0.149616682504908 0.433560211422392 no 1933 0.440533522802259 2922 3973534
SGTC_1351 1496-0003 46.5 µM -0.150004833685331 0.43338609152206 no 1934 0.440380400841494 2782 3891978
SGTC_183 3914-0051 30.55 µM -0.150012665956192 0.433382578193538 no 1935 0.44037731117658 2753 1596232
SGTC_259 usnic acid 108.925 µM -0.150504617697453 0.433161913536181 no 1936 0.440183253920097 2849 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1488 4013-0813 75.9 µM -0.151255461375332 0.432825163249403 no 1937 0.439887100826471 2671 2910057
SGTC_291 SEC14.278 35.5 µM -0.151789291475595 0.432585772309473 no 1938 0.439676564215058 2744 1068044
SGTC_911 3456-4043 236 µM -0.151842196787867 0.432562048780572 no 1939 0.439655699880696 2766 914281
SGTC_75 0159-0059 199.013 µM -0.153752944604246 0.431705404637988 no 1940 0.438902268655028 2968 5377270
SGTC_2957 9076800 11.52 µM -0.154638911949259 0.431308308262768 no 1941 0.438552995835034 2727 16459615
SGTC_2057 5236571 38.335 µM -0.154873613592192 0.431203125061195 no 1942 0.438460477964845 2770 54684039 YBR257W POP4
SGTC_2883 9059145 45.46 µM -0.155702005310552 0.430831914501212 no 1943 0.438133958220592 2655 16476510
SGTC_1490 4089-0339 670 nM -0.156151094761049 0.430630698576168 no 1944 0.437956962243577 2688 742542
SGTC_2833 9001315 45.46 µM -0.156160949140602 0.430626283492487 no 1945 0.437953078556048 2730 2989378
SGTC_1340 1486-1359 257 µM -0.156318622107193 0.430555642036823 no 1946 0.437890939228227 2724 4309068
SGTC_1040 k898-0338 155 µM -0.157313001707198 0.430110186249202 no 1947 0.437499086979477 2754 20969351
SGTC_354 2783-3500 4.88 µM -0.157395993535083 0.430073012116632 no 1948 0.437466385399591 2717 6740761
SGTC_1509 1326-1131 80 µM -0.157424124167906 0.430060411837443 no 1949 0.437455301078206 2670 768313
SGTC_1172 0370-0043 85 µM -0.157569841456094 0.429995143258306 no 1950 0.437397884838882 2829 376585
SGTC_2159 5658611 73.75 µM -0.157706251805728 0.429934045105842 no 1951 0.43734413695972 2676 793844
SGTC_264 promethazine 12.5 mM -0.157977739385798 0.429812450898593 no 1952 0.437237169913396 2691 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_3203 9113543 49.47 µM -0.15814026701078 0.429739661001358 no 1953 0.437173135661333 2866 17018012
SGTC_594 1487-1584 10.8 µM -0.158598914106421 0.42953426342409 no 1954 0.436992442192332 2714 5013332
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.159450793322163 0.42915281394811 no 1955 0.43665686173647 2785 616764
SGTC_2278 7948257 134.34 µM -0.160442964994494 0.428708628550331 no 1956 0.436266073400237 2784 1247028
SGTC_2122 5258151 111.688 µM -0.161145072251728 0.428394356624683 no 1957 0.435989570787839 2733 2173356
SGTC_1026 k007-1105 30.6 µM -0.162563278295536 0.427759688677948 no 1958 0.435431150992668 2690 7066794
SGTC_3158 9100007 49.47 µM -0.163059571262538 0.427537634371524 no 1959 0.435235765578966 2718 19297233
SGTC_235 0330-0087 5 mM -0.163699450299447 0.427251369827501 no 1960 0.434983875153951 2712 46494818 YHR062C RPP1
SGTC_2740 felodipine 17.08 µM -0.163822170344113 0.427196472577219 no 1961 0.434935569028852 2790 3333 L-type calcium channel blocker
SGTC_610 4215-0184 155 µM -0.164300634186824 0.426982451339218 no 1962 0.434747241234812 2760 5605015
SGTC_1826 st055655 41.6 µM -0.164488195818406 0.426898559172309 no 1963 0.434673419278622 2746 676168
SGTC_2848 9016370 25.97 µM -0.164632918850722 0.426833830022496 no 1964 0.434616459625839 2728 7894410
SGTC_2128 5255449 168.493 µM -0.165628957180611 0.426388393205781 no 1965 0.434224478749438 2718 736008
SGTC_1405 3909-7894 12 µM -0.165714108589461 0.426350317119276 no 1966 0.434190971262968 2807 7104060
SGTC_1162 k048-0130 20.1 µM -0.166130146816937 0.426164292405129 no 1967 0.434027265034362 2695 6797406
SGTC_1203 3992-3522 103 µM -0.166957222440228 0.425794527847294 no 1968 0.433701853977534 3051 5322312
SGTC_952 1185-0122 232 µM -0.168659537636771 0.425033671532689 no 1969 0.433032223518133 2662 678600
SGTC_1785 bathophenanthroline 24 µM -0.168713213587296 0.425009685385622 no 1970 0.433011112418048 2721 72812 An iron chelator.
SGTC_1836 st055642 81 µM -0.168756453495597 0.42499036298979 no 1971 0.432994106020208 2721 8571
SGTC_1498 4478-3555 97.6 µM -0.169345808750958 0.424727018818322 no 1972 0.432762323049648 2722 3437919
SGTC_1131 3454-3128 32.3 µM -0.170204033596678 0.424343594585116 no 1973 0.43242483982708 2888 710982
SGTC_956 1185-0240 191 µM -0.17042159867132 0.424246405634332 no 1974 0.43233929365652 2749 1416193
SGTC_3276 9139060 49.47 µM -0.172307606896473 0.423404096602947 no 1975 0.431597852179201 2695 4870619
SGTC_2020 4017018 200 µM -0.174386747831043 0.422475938317457 no 1976 0.430780764224061 2811 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2968 9090663 33.37 µM -0.174939980151204 0.422229039755054 no 1977 0.430563397514914 2814 25236811
SGTC_1588 farnesol 29.9 µM -0.175148648246417 0.422135922518486 no 1978 0.430481416627683 2711 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_54 0159-0055 9 µM -0.17572225951453 0.421879973408231 no 1979 0.430256073424413 2932 3319099
SGTC_2985 9022375 71.43 µM -0.178447915989672 0.420664220283412 no 1980 0.429185610804375 2922 4939335
SGTC_1192 1488-0095 21.4 µM -0.178989554203478 0.42042271742786 no 1981 0.428972951890648 2792 915875
SGTC_2673 kobusone 100 µM -0.180101174577893 0.419927167776731 no 1982 0.428536570253677 2733 6710676 An epoxy ketone and protein crosslinker.
SGTC_2062 5245942 200 µM -0.180144803104654 0.419907721183417 no 1983 0.428519445062613 2688 1376160
SGTC_2656 pseudo-anisatin 100 µM -0.180232927446683 0.419868442015764 no 1984 0.428484854660512 2733 6708809 A neurotoxin.
SGTC_2809 7964133 12.99 µM -0.180481699874272 0.419757562388478 no 1985 0.428387209937393 2782 1253665
SGTC_3054 9094397 49.47 µM -0.181126796032325 0.419470068172784 no 1986 0.428134026126572 2758 2598354
SGTC_2051 5263410 176 µM -0.181277180290533 0.419403053942319 no 1987 0.428075008383691 2719 227584
SGTC_1640 st009078 66.4 µM -0.181693525441369 0.419217534424497 no 1988 0.427911623674519 2848 690618
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.183109414264291 0.418586762184914 no 1989 0.427356084574194 2863 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_1929 genistein trimethyl ether 50.5 µM -0.183127102293584 0.418578883565877 no 1990 0.427349145395538 2842 136420
SGTC_1153 4055-0057 267 µM -0.183458639092072 0.418431216172731 no 1991 0.427219084582509 2732 882706
SGTC_3338 9144300 39.5675 µM -0.184804088322395 0.417832067612263 no 1992 0.426691350539233 2804 4901274
SGTC_1190 1486-1332 13 µM -0.184873812484037 0.417801023590343 no 1993 0.426664005759068 2710 4150046
SGTC_1395 3486-0190 4.35 µM -0.186291374578643 0.417169978839393 no 1994 0.426108135579612 2822 6748079
SGTC_126 0417-1624 672.48 µM -0.186567480032825 0.417047091958093 no 1995 0.42599988308937 2760 41912 YDL195W SEC31
SGTC_2101 5377231 179.231 µM -0.186956014054453 0.416874179967022 no 1996 0.42584756024822 2857 2844213
SGTC_2336 9001819 198.65 µM -0.190640123129 0.415235418987668 no 1997 0.4244037764693 2963 2989602
SGTC_2015 5119600 184 µM -0.190954981706425 0.415095431921388 no 1998 0.424280431730769 2908 2828786
SGTC_359 0081-0058 15.9 µM -0.191454359894628 0.414873428994936 no 1999 0.424084817297499 3131 3494159
SGTC_1697 st025554 27.742 µM -0.191900868850325 0.414674952562504 no 2000 0.423909928424194 2725 1269519
SGTC_3263 9137018 49.47 µM -0.19210996552433 0.414582015076626 no 2001 0.423828034473585 2781 43844957
SGTC_3015 9080845 49.47 µM -0.193674795030504 0.413886645290039 no 2002 0.423215264395725 2864 5296973
SGTC_2298 7976326 193.81 µM -0.194605731444016 0.413473089120725 no 2003 0.422850807901485 2780 2235818
SGTC_3154 9100113 49.47 µM -0.195149499800968 0.413231571602366 no 2004 0.422637956100367 2765 25237525
SGTC_62 0180-0423 3.232 µM -0.195563574672016 0.413047680128666 no 2005 0.422475886451029 2796 30102 YGL099W LSG1
SGTC_2766 oltipraz 83.91 µM -0.196567335189043 0.412601987335941 no 2006 0.422083067297013 2892 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3258 9138477 49.47 µM -0.197182345141868 0.412328964372236 no 2007 0.421842422962887 2774 4970355
SGTC_2683 piperine 63.03 µM -0.197192628837278 0.412324399464885 no 2008 0.421838399352179 2774 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1850 st056238 17 µM -0.199276881910718 0.411399450241418 no 2009 0.421023081030545 2718 5393177
SGTC_2156 5649887 115 µM -0.199444771226747 0.411324965723249 no 2010 0.420957420760477 2871 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2518 prenyletin 46.28 µM -0.200381221300369 0.410909565993188 no 2011 0.420591222443077 2856 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1233 0325-0408 14.2 µM -0.202971847883266 0.409760912156 no 2012 0.419578518164185 2857 12874
SGTC_3193 9111931 49.47 µM -0.203026865864106 0.409736526179564 no 2013 0.419557016783448 2774 17087244
SGTC_972 1319-0219 195 µM -0.203175812347401 0.409670509416304 no 2014 0.419498808745292 2837 23903702
SGTC_801 0866-0028 10.1 µM -0.203754396990882 0.409414090711626 no 2015 0.419272715550551 2752 6849771
SGTC_2546 rhodinyl acetate 100 µM -0.206069957168126 0.408388263408241 no 2016 0.418368132909636 2781 6708682
SGTC_2786 7743617 45.45 µM -0.206493542984227 0.408200676328583 no 2017 0.418202704007459 2807 583674
SGTC_2427 5545055 42.75 µM -0.206775725747615 0.408075721964435 no 2018 0.418092507248506 2790 5372858
SGTC_339 3091-4833 71.4 µM -0.207983027559102 0.407541218013743 no 2019 0.41762110981479 2786 3240077
SGTC_1156 4092-0367 4.88 µM -0.208420690922757 0.407347495491368 no 2020 0.417450251013696 2807 1357585
SGTC_509 pifithrin 175 µM -0.209595094856276 0.406827782287343 no 2021 0.416991854174796 2788 4817 A p53 inhibitor.
SGTC_2774 tamoxifen 10.92 µM -0.209602804023822 0.406824371262604 no 2022 0.416988845481638 2759 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1857 st056007 79.3 µM -0.210121187853574 0.406595021604022 no 2023 0.416786544543936 2857 619834
SGTC_1151 3909-8316 15.3 µM -0.210211597454677 0.40655502477097 no 2024 0.416751264164756 2871 800431
SGTC_2098 5376439 882.5 nM -0.210667682024232 0.406353269718064 no 2025 0.416573297316108 2870 2844116
SGTC_3037 9091026 49.47 µM -0.210923478323789 0.406240125713568 no 2026 0.416473491595863 2860 25236398 YIL048W NEO1
SGTC_2612 dictamnine 15.46 µM -0.211238306582786 0.40610088139864 no 2027 0.416350660381519 2878 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1860 st056228 74.6 µM -0.212791529379535 0.405414085952974 no 2028 0.415744785509399 2892 688679
SGTC_1975 st070967 30.8 µM -0.213287335392944 0.405194914394627 no 2029 0.415551425592742 2880 261391
SGTC_2035 5154463 94.595 µM -0.213487782615737 0.405106314928719 no 2030 0.415473258767793 2907 2769623
SGTC_3267 9137951 49.47 µM -0.213934859556393 0.404908720447791 no 2031 0.415298927748611 2742 16643986
SGTC_967 1306-0166 352 µM -0.214278218855089 0.404756982482493 no 2032 0.415165051202983 2915 4437607
SGTC_830 4076-0286 57.8 µM -0.215057872167343 0.404412489885573 no 2033 0.414861099259835 2798 6866659
SGTC_2073 5212005 126 µM -0.215303845298109 0.404303821143527 no 2034 0.414765215907881 2742 691789
SGTC_3208 9114115 49.47 µM -0.215425863614042 0.404249917275569 no 2035 0.414717653551311 2864 650895
SGTC_2300 7976697 71.57 µM -0.215686546721473 0.404134761739832 no 2036 0.414616044283746 2800 2236109
SGTC_318 1488-0629 67.2 µM -0.21575228316719 0.404105724285372 no 2037 0.414590422381693 2865 3662576
SGTC_582 0987-0078 156 µM -0.216360054007165 0.403837281543058 no 2038 0.414353550545072 2817 1625765
SGTC_2330 7979373 200 µM -0.216870346538662 0.403611928391783 no 2039 0.414154693830837 2801 1863007
SGTC_361 000s-0510 1.45 µM -0.217013065753661 0.403548907080133 no 2040 0.414099081287101 2867 660
SGTC_1766 st045414 44.774 µM -0.21739914235789 0.403378437657484 no 2041 0.413948649758472 2775 253960
SGTC_352 k048-0007 5.11 µM -0.217439422273635 0.403360653399577 no 2042 0.413932955752242 2851 6811911
SGTC_1147 3809-1045 12.3 µM -0.217461286308765 0.403351000145299 no 2043 0.413924437065473 2791 325925
SGTC_1560 lithocholic acid 53.1 µM -0.217538831801903 0.403316763282043 no 2044 0.413894224041129 2785 9903 A bile acid which acts as a detergent.
SGTC_1674 st016616 23.6 µM -0.217593970835842 0.403292419473874 no 2045 0.413872741259013 2737 625830
SGTC_2007 4011539 71.82 µM -0.218591787801722 0.402851949488703 no 2046 0.413484025245802 2786 45595301
SGTC_2882 9058044 58.44 µM -0.21900078159127 0.402671441452967 no 2047 0.413324719461897 2894 18076804
SGTC_93 0109-0045 59.227 µM -0.219417834747837 0.402487397805895 no 2048 0.413162289194338 2743 88733
SGTC_1682 st012968 530 nM -0.219604594604226 0.402404988540149 no 2049 0.413089556392309 2807 24207270
SGTC_2151 5563267 85.4165 µM -0.219747119694676 0.402342101132898 no 2050 0.413034052631409 2832 5310824
SGTC_209 4077-0173 175.592 µM -0.220593389658787 0.401968747244039 no 2051 0.412704524283584 2881 15993494
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.220648955569368 0.40194423603039 no 2052 0.412682889670062 2763 688667
SGTC_2779 methotrexate 400 µM -0.221352081255623 0.401634106838873 no 2053 0.412409150287825 2849 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_3052 9092717 49.47 µM -0.22207711320186 0.401314380272126 no 2054 0.41212692702148 2978 25237534
SGTC_2183 6420625 130.508 µM -0.222266956692994 0.401230673476868 no 2055 0.412053036743664 2785 2897619
SGTC_1419 3993-2473 62.6 µM -0.22299696621344 0.400908836084628 no 2056 0.411768933835186 2831 704026
SGTC_2661 dactinomycin 12.96 µM -0.22335012008782 0.400753166176472 no 2057 0.411631511061502 2833 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2441 5730946 39.09 µM -0.224763323084492 0.400130385524047 no 2058 0.411081699988004 2930 1774275
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM -0.22496863636769 0.400039927647072 no 2059 0.411001836711089 2800 688664
SGTC_1418 3966-3099 2.4 µM -0.225969552044715 0.399599016473571 no 2060 0.410612550899504 2882 740335
SGTC_1013 4112-3890 241 µM -0.226703853802863 0.39927563218135 no 2061 0.410327015117371 2794 705171
SGTC_3141 9094609 49.47 µM -0.227389601961673 0.398973693144902 no 2062 0.410060402486355 2770 25236309 YDL196W YDL196W
SGTC_1767 st044992 70.3 µM -0.227715359412047 0.398830281345779 no 2063 0.409933765517006 2871 9600693
SGTC_1819 st053448 58.6 µM -0.227910396144099 0.398744424706913 no 2064 0.40985795022438 2834 2857616
SGTC_2756 carbadox 75.1 µM -0.228357430225685 0.398547655427907 no 2065 0.409684190447167 2844 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.229435370615236 0.398073288691825 no 2066 0.409265273747562 2825 4174840
SGTC_1812 st052057 4.327 µM -0.230205230935127 0.397734590196005 no 2067 0.408966148655579 2780 3645418
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.232934467259516 0.396534490726104 no 2068 0.407906146744553 2959 61125 An anti-inflammatory.
SGTC_565 1418-0001 44.5 µM -0.233978512698692 0.39607566159209 no 2069 0.407500830039578 2997 2862145
SGTC_3020 9089140 49.47 µM -0.234447637110623 0.395869541199457 no 2070 0.407318739946809 2896 17217859
SGTC_421 streptovitacin 30 mM -0.235009881283743 0.395622544900114 no 2071 0.407100531914057 3023 91467 include heat shock
SGTC_746 1095-0025 46.6 µM -0.23559140942039 0.395367121167888 no 2072 0.406874870069948 3003 6749286
SGTC_1570 verbenone 133 µM -0.235603363788803 0.395361870939636 no 2073 0.40687023150439 3005 29025 A natural terpanoid with antifungal properties.
SGTC_2190 6049624 200 µM -0.236216167330114 0.395092759768194 no 2074 0.406632467372309 2848 2265554
SGTC_2476 5806916 10.51 µM -0.23803234634035 0.394295483548926 no 2075 0.405928003175936 2830 2870194
SGTC_1037 k284-1091 78.7 µM -0.239546752880121 0.393631019350401 no 2076 0.405340823966465 2808 3334711
SGTC_1732 st034308 51.822 µM -0.240374706018372 0.393267875673066 no 2077 0.405019892557677 2759 830119
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.240675480637954 0.393135977651676 no 2078 0.40490332202563 2815 66535 A nucleotide analog.
SGTC_140 0062-0056 502.533 µM -0.241242701003072 0.392887269163245 no 2079 0.404683508694422 2792 3758964
SGTC_198 3454-2873 16.191 µM -0.241761472841621 0.392659842123274 no 2080 0.404482496817333 2829 710957
SGTC_2677 mitomycin C 100 µM -0.242643962170238 0.392273047341401 no 2081 0.404140610917704 2853 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1409 3909-8004 61.9 µM -0.246773281773107 0.390464587608911 no 2082 0.40254184458086 2875 2119279
SGTC_2916 7875993 68.79 µM -0.247924971796775 0.389960618724632 no 2083 0.40209622913636 2858 1299250
SGTC_867 0518-0118 155 µM -0.25095499713577 0.38863559297272 no 2084 0.400924451506757 2895 6848158
SGTC_1752 st044819 83.042 µM -0.251509523799282 0.388393238953547 no 2085 0.400710099935841 2875 441209 YML126C ERG13
SGTC_973 1325-0077 65.9 µM -0.252350517775266 0.38802576829151 no 2086 0.400385071859111 2905 2835149
SGTC_2730 imipramine 71.33 µM -0.254118707591008 0.387253488524123 no 2087 0.399701925544802 2855 3696 A tricyclic antidepressant.
SGTC_1717 st033143 58.0435 µM -0.254216989386845 0.387210575735588 no 2088 0.399663963014106 3024 674616
SGTC_3194 9111903 49.47 µM -0.255379635650551 0.386703034134888 no 2089 0.399214948922404 3059 17087251
SGTC_1992 st073643 23.3 µM -0.255410748070194 0.386689454976703 no 2090 0.399202935131888 2827 3161292
SGTC_1364 1653-0028 37.6 µM -0.255466319749142 0.386665200807866 no 2091 0.399181476848464 2924 5718652
SGTC_2420 aureobasidin a 50 nM -0.256162324537287 0.3863614681721 no 2092 0.398912749442775 3138 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1700 st030840 7.9285 µM -0.256174705301812 0.38635606590468 no 2093 0.398907969663671 2961 5499307
SGTC_684 1140-0066 328 µM -0.256389993967347 0.38626212959527 no 2094 0.398824856682456 2918 6813534
SGTC_1124 fisetin 1.16336 µM -0.259162698152098 0.385052920852671 no 2095 0.397754855311835 2919 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_2304 7443016 91.4 µM -0.25995045243448 0.384709575228943 no 2096 0.397450996593326 2796 939854
SGTC_1472 k841-0093 193 µM -0.260732700977707 0.384368718755216 no 2097 0.397149323157191 2963 X1472
SGTC_511 blebbistatin 171 µM -0.260854418898849 0.384315689497285 no 2098 0.397102388278947 2999 3476986 A myosin inhibitor.
SGTC_2654 protoveratrine a 100 µM -0.261240354507868 0.38414756194731 no 2099 0.39695357994456 2874 5702278 A heart drug and vasodilator.
SGTC_855 0428-0020 25 µM -0.261398209489563 0.384078800870879 no 2100 0.39689271883617 2887 6812414
SGTC_2243 6634756 200 µM -0.261939105718759 0.383843216053418 no 2101 0.396684194936839 3130 885676
SGTC_2418 pentamidine 31.67 µM -0.261944367290791 0.383840924611036 no 2102 0.396682166664072 2891 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3087 9117406 49.47 µM -0.262396689323805 0.38364395116918 no 2103 0.396507812413131 2994 42546093
SGTC_2658 polymyxin b sulfate 77.05 µM -0.262487568837028 0.383604379339001 no 2104 0.39647278404926 2894 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_429 1112-0049 25.5 µM -0.263533566653561 0.38314900611927 no 2105 0.396069677586692 2856 2836170
SGTC_708 3448-5400 146 µM -0.264071731583474 0.382914779858999 no 2106 0.395862322936942 2941 3462195
SGTC_2517 totarol 10 µM -0.264212371455594 0.382853576026608 no 2107 0.395808139326139 2948 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_824 1304-0008 100 µM -0.265216267994757 0.382416784137287 no 2108 0.395421431731316 2886 768245
SGTC_555 4296-0685 37 µM -0.265244356609851 0.382404565026974 no 2109 0.395410613289592 2903 2908540 YHR072W ERG7
SGTC_1109 tnp00067 928.257 nM -0.265601918091884 0.38224902885487 no 2110 0.39527290411017 2905 676295
SGTC_1460 k062-0059 9.15 µM -0.265786397619375 0.382168789273504 no 2111 0.395201859835618 2779 1373085
SGTC_79 0052-0007 94.094 µM -0.266198708518255 0.38198947247485 no 2112 0.3950430888035 3040 2801472
SGTC_490 phenamil 164 µM -0.267732259372216 0.381322743287784 no 2113 0.394452708308388 2967 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_2783 7738165 71.43 µM -0.267930092516662 0.381236758609071 no 2114 0.394376564888444 2944 17201110
SGTC_1879 gemcitabine 100 µM -0.26807211526506 0.381175034547072 no 2115 0.394321904656989 2892 60750 A nucleoside analog which inhibits DNA replication.
SGTC_370 0180-0345 38.7 µM -0.270668369534528 0.380047218808364 no 2116 0.393323053213637 2810 3989527
SGTC_1905 st060207 84.5 µM -0.273527996449274 0.378806173498173 no 2117 0.392223687260221 2838 1948547
SGTC_2743 auranofin 4.32 µM -0.274054249406001 0.37857792139526 no 2118 0.392021465954598 2923 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_672 1441-0018 53.7 µM -0.274378264514222 0.378437407131758 no 2119 0.391896972351982 2878 251141
SGTC_2017 5132927 60.65 µM -0.274582475482092 0.378348856079571 no 2120 0.391818515772501 2909 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_985 1493-0307 8.71 µM -0.275904567200203 0.377775718354464 no 2121 0.39131068295309 3035 3278274
SGTC_410 α-linolenic acid 100 µM -0.277092819195082 0.377260830712339 no 2122 0.390854417742271 3005 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2621 lithochol-11-enic acid 100 µM -0.277126503201588 0.377246238095544 no 2123 0.390841485937995 2962 6708711
SGTC_3098 9119039 49.47 µM -0.27734629735076 0.377151022973117 no 2124 0.39075710657336 2875 17161528
SGTC_1802 st050112 57.9 µM -0.277966833553727 0.37688224617777 no 2125 0.390518909393948 2879 4662563
SGTC_1795 st049545 62.3 µM -0.278330370431759 0.376724812838352 no 2126 0.390379382288904 2996 5291882
SGTC_2597 laccaic acid a 100 µM -0.278583852526414 0.376615051968919 no 2127 0.390282103062018 3040 5491415 A textile dye.
SGTC_439 amiodarone 34.4 µM -0.278894156234025 0.376480700220211 no 2128 0.390163026666453 2944 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_214 4373-3496 70 µM -0.280301743463294 0.375871447300286 no 2129 0.389623006644468 2935 3779166
SGTC_3153 9100258 49.47 µM -0.281152227877827 0.37550347773893 no 2130 0.389296821970547 2923 25236848
SGTC_2895 9054447 58.44 µM -0.282755287924438 0.374810207791718 no 2131 0.388682215598007 2918 2697450
SGTC_903 1134-0042 114 µM -0.282780870119915 0.37479914761851 no 2132 0.388672409747542 2911 701009
SGTC_2312 7706453 155.7 µM -0.28515719579776 0.373772220249331 no 2133 0.38776185612993 2949 976098
SGTC_2244 6635614 200 µM -0.285791978770867 0.373498050508998 no 2134 0.387518726016265 2837 836499
SGTC_3032 9089427 49.47 µM -0.287251545612983 0.372867890586862 no 2135 0.386959860417659 3018 17173707
SGTC_2123 5259487 200 µM -0.288070452703598 0.372514480773373 no 2136 0.38664640484034 3025 2173474
SGTC_1757 st041620 31.8375 µM -0.288599766374338 0.37228610577756 no 2137 0.38644383715184 2985 5289815
SGTC_2592 piperlongumine 83.33 µM -0.290018148426284 0.37167435944012 no 2138 0.385901176781903 2999 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_575 k072-0246 11.9 µM -0.29178971463651 0.370910740298753 no 2139 0.385223704867429 2909 6796779
SGTC_1980 st071811 45.7 µM -0.292354992568547 0.370667188649175 no 2140 0.385007608198252 3072 4974850
SGTC_1288 0973-0013 65.5 µM -0.293906677478962 0.369998907274981 no 2141 0.384414607728972 3027 4315430
SGTC_27 0485-0001 32.618 µM -0.294468980519822 0.369756830721264 no 2142 0.384199781569907 2906 2054479
SGTC_757 1066-0008 322 µM -0.295394034599437 0.369358698881913 no 2143 0.383846444901451 3075 6842497
SGTC_3092 9117248 49.47 µM -0.295665323054205 0.369241966227888 no 2144 0.383742840974712 2955 17141857
SGTC_2949 9072542 2.23 µM -0.296426614358591 0.368914454763906 no 2145 0.383452151409029 3034 16457352
SGTC_3046 9092212 49.47 µM -0.296432352948715 0.368911986353773 no 2146 0.383449960449027 2936 25236637
SGTC_885 0865-0106 16.8 µM -0.296709306099897 0.368792863528179 no 2147 0.383344225794347 2934 2793380
SGTC_2674 ligustilide 100 µM -0.296766638293132 0.36876820543418 no 2148 0.383322338702337 3020 5319022 A signalling regulator.
SGTC_1256 0570-0116 285 µM -0.299407241877027 0.36763309101984 no 2149 0.382314668625404 2961 410638
SGTC_622 1348-1566 26.3 µM -0.299515485716039 0.36758658490079 no 2150 0.382273379078639 3014 7340407
SGTC_2225 6654152 15.4 µM -0.300229849176975 0.367279712946382 no 2151 0.382000919158602 2994 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1113 artemisinin 1.17947 µM -0.301504476875348 0.366732376685638 no 2152 0.381514918346928 3037 2240 An anti-malaria and mitochondrial poison.
SGTC_1625 st003711 30.1 µM -0.301912201195725 0.366557353427453 no 2153 0.381359497160996 3139 24207034 YER133W GLC7
SGTC_927 2425-1185 123 µM -0.305890277085071 0.364851151354693 no 2154 0.379844094564 2903 730375
SGTC_1964 st076914 61 µM -0.307211785326338 0.364284944477429 no 2155 0.379341087806792 2911 24208661
SGTC_2940 9060638 45.86 µM -0.307578995237279 0.364127664046054 no 2156 0.379201352614525 3040 4027022
SGTC_2106 5357045 167.29 µM -0.307683320736429 0.364082984349861 no 2157 0.379161656281641 3030 668842
SGTC_584 0986-0246 15.4 µM -0.308250154499669 0.363840257589386 no 2158 0.378945995703737 2984 53315 YDR232W HEM1
SGTC_13 0199-0087 65 µM -0.308606167034293 0.363687835579719 no 2159 0.378810564547833 2936 4589825
SGTC_1627 st003713 25.6 µM -0.30871099173869 0.36364296039291 no 2160 0.378770690890839 3028 16195070 YER133W GLC7
SGTC_1827 berberine 7.24 µM -0.308878704081432 0.363571167060514 no 2161 0.378706898456267 2946 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3232 9132874 49.47 µM -0.309201685956273 0.363432920341234 no 2162 0.378584055747268 2954 3784940
SGTC_2543 pimpinellin 60.67 µM -0.310974388596565 0.362674463218231 no 2163 0.377910045961699 2961 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2486 5283202 22.39 µM -0.312367700594344 0.36207870751943 no 2164 0.37738054716216 2992 1377751
SGTC_1782 st039423 80.636 µM -0.313320501951837 0.361671498611859 no 2165 0.377018587722793 2995 2068169
SGTC_981 1488-1094 54.9 µM -0.315190640925322 0.360872693016083 no 2166 0.376308455573962 2911 3449522
SGTC_995 3931-2021 34.6 µM -0.316631554158939 0.360257639091616 no 2167 0.375761595009849 3064 730143
SGTC_2942 9052777 62.25 µM -0.317086464907609 0.360063535407137 no 2168 0.375588997407701 2992 6469503
SGTC_2450 5739737 12.93 µM -0.31723478976171 0.360000255183036 no 2169 0.375532726882741 3057 2262825
SGTC_1680 diphenhydramine 100 µM -0.318102635528593 0.359630080797167 no 2170 0.375203542264176 3009 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2431 5490079 200 µM -0.322949227092772 0.357565225870619 no 2171 0.373366847119 3034 5722345
SGTC_1534 6-azauridine 81.6 µM -0.323379975597567 0.357381909149157 no 2172 0.373203746356555 2968 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3355 9151058 44.0485 µM -0.323645890840252 0.357268758122206 no 2173 0.373103070221949 3027 17015728
SGTC_2684 capsaicin 100 µM -0.323739094903486 0.357229101328986 no 2174 0.373067784995252 3068 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_881 0833-0569 170 µM -0.323741884970566 0.357227914225184 no 2175 0.373066728747097 2985 5418700
SGTC_1594 piperine 70.1 µM -0.323992464775299 0.357121304418333 no 2176 0.372971869522851 2961 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1884 5633444 25 µM -0.324186834806788 0.357038616881719 no 2177 0.372898294313762 3134 5724239
SGTC_260 nsc-65238 3.989 µM -0.324550903568474 0.35688375537064 no 2178 0.372760495240167 3104 3246252
SGTC_3247 9135149 49.47 µM -0.325819197545646 0.356344453895194 no 2179 0.372280576547332 2987 8934436 YOR116C RPO31
SGTC_182 3448-4371 550.524 µM -0.325905890833403 0.356307600819256 no 2180 0.372247779295401 2988 3491403
SGTC_1219 1469-0211 33.1 µM -0.325977731059222 0.356277062755478 no 2181 0.372220601861258 3095 6822282
SGTC_2011 4012611 177 µM -0.327511840450732 0.355625159105461 no 2182 0.371640394480675 2954 2049887
SGTC_2351 9026858 72.31 µM -0.329997912782259 0.354569625675905 no 2183 0.370700769611893 2939 1409300
SGTC_920 mycophenolic acid 780.421 nM -0.330258153456583 0.354459197398266 no 2184 0.370602454664111 3018 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_649 1123-0311 367 µM -0.331172807353336 0.354071178180444 no 2185 0.370256979481571 3096 693629 YIL048W NEO1
SGTC_2769 toremifene 3.73 µM -0.332088156079693 0.353683015845141 no 2186 0.369911346604821 3198 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_3182 9108849 49.47 µM -0.3330005541688 0.353296256088452 no 2187 0.369566932420284 3092 17133045
SGTC_2936 9038235 15.59 µM -0.333474793059776 0.353095289028221 no 2188 0.369387956912395 2944 4749415
SGTC_1081 sertraline 6 µM -0.334526429987353 0.352649785626453 no 2189 0.368991175143331 3105 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2842 9000675 19.48 µM -0.338232811227414 0.351081270978565 no 2190 0.367593875806908 3054 2989072
SGTC_2519 cryptotanshinone 88.04 µM -0.34427193044377 0.348530994742047 no 2191 0.365320895888381 3163 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_2689 tacrolimus 100 µM -0.345187751495879 0.348144843849129 no 2192 0.364976613198778 3083 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1204 4049-0315 18.3 µM -0.345836653305881 0.347871333221294 no 2193 0.364732738754237 3242 588402
SGTC_541 4513-1321 94 µM -0.345961317966941 0.347818796410277 no 2194 0.36468589274455 3016 747515
SGTC_2665 lovastatin 100 µM -0.346506937732393 0.347588892962947 no 2195 0.364480885615762 3048 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1870 st057514 26.5 µM -0.346810936962023 0.347460823539515 no 2196 0.364366680005657 2973 5393161
SGTC_2508 celastrol 40.54 µM -0.347874117552574 0.347013061630151 no 2197 0.363967361938028 3047 122724 Celastrol is a natural product and antioxidant.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.348408864949518 0.346787931717676 no 2198 0.36376657292155 2992 803109
SGTC_2449 5812982 45.77 µM -0.348475568466275 0.346759853172624 no 2199 0.363741529450571 3110 776185
SGTC_2945 9067681 61.76 µM -0.349226065163829 0.346443993007034 no 2200 0.363459799708287 3033 16456930
SGTC_852 0418-0143 439 µM -0.349928486615906 0.346148462881778 no 2201 0.36319618386725 3123 5369229
SGTC_3279 9140807 49.47 µM -0.350313796691175 0.345986390954211 no 2202 0.363051606112947 3042 45595718
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.350518424475609 0.345900330393853 no 2203 0.362974832700886 2989 15053
SGTC_2256 7954252 200 µM -0.351842292254049 0.345343742202841 no 2204 0.362478269659495 3102 2972920
SGTC_3135 9127742 49.47 µM -0.353048913814996 0.344836738483447 no 2205 0.362025885333573 3074 3643468
SGTC_187 1488-2104 32.728 µM -0.353190624816355 0.344777211970159 no 2206 0.361972767938661 3089 2852859
SGTC_1076 itraconazole 331 nM -0.353328714832009 0.34471921016894 no 2207 0.361921010351728 3070 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1209 2323-2347 50.3 µM -0.353818691520915 0.344513435244482 no 2208 0.36173738232959 3126 5412760
SGTC_1822 st052468 42 µM -0.354269349513481 0.34432421356001 no 2209 0.361568517833396 3088 2873678
SGTC_468 gf-109203x 121 µM -0.355061064741409 0.343991883581616 no 2210 0.361271922259777 3085 2396 A protein kinase C inhibitor.
SGTC_3062 9077494 49.47 µM -0.355281028878779 0.34389957292311 no 2211 0.361189533192463 3143 16459633
SGTC_3171 9103192 49.47 µM -0.355435745012949 0.343834649965788 no 2212 0.361131587066292 3132 13018434
SGTC_397 arbidol 50 µM -0.355879760499285 0.343648354970428 no 2213 0.360965306805624 3171 131410 A RNA synthesis inhibitor.
SGTC_611 3453-1652 23.7 µM -0.356210160500559 0.343509754108911 no 2214 0.360841591685841 3136 1560575
SGTC_194 1486-1323 56.904 µM -0.356896256346317 0.343222008149658 no 2215 0.360584736180881 3087 5178754
SGTC_861 0443-0273 110 µM -0.35701903213357 0.343170526037416 no 2216 0.360538778917375 3124 6149169
SGTC_1371 2421-0008 32.7 µM -0.357223353711307 0.343084856750427 no 2217 0.360462302011888 3050 2827552
SGTC_2071 5230951 39.92 µM -0.357590041850092 0.34293112957723 no 2218 0.360325065827266 3120 1799272
SGTC_2926 9010726 65.15 µM -0.358103429714012 0.342715944960977 no 2219 0.36013295624627 3152 2994293
SGTC_320 4092-0846 5.34 µM -0.358486673170662 0.342555343146591 no 2220 0.359989569681412 3123 1359356
SGTC_2294 7971431 200 µM -0.359019986535161 0.342331900471644 no 2221 0.359790068799302 3147 5741572
SGTC_203 k066-0004 30.888 µM -0.359394541540218 0.342175005878624 no 2222 0.359649978781456 3117 6795412
SGTC_1617 st002906 78 µM -0.36070703047026 0.341625442164394 no 2223 0.359159234254715 3014 5150859
SGTC_2773 thioridazine 9.09 µM -0.361499453757473 0.341293802050453 no 2224 0.358863056626131 3082 5452 An antipsychotic.
SGTC_2261 9010538 184.68 µM -0.362654171073125 0.340810756293269 no 2225 0.358431619213428 3130 6457250
SGTC_2687 chenodiol 100 µM -0.364957964685495 0.339847804677353 no 2226 0.3575713922312 3153 5702181 A cholesterol synthesis inhibitor.
SGTC_1169 aniline yellow 25.8 µM -0.36555821257158 0.33959708115501 no 2227 0.357347380721863 3065 6051 A DNA damaging agent.
SGTC_409 arachidonic acid 100 µM -0.366495503987773 0.339205716519089 no 2228 0.356997683448033 3066 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_3053 9095903 49.47 µM -0.367257251511774 0.338887777686316 no 2229 0.356713568905665 3126 17174018
SGTC_2777 climbazole 1.536 µM -0.367919452745203 0.338611480783131 no 2230 0.356466647438242 3120 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1295 1013-0063 9.78 µM -0.367987596794395 0.338583053279218 no 2231 0.356441241310274 3182 6826038
SGTC_3196 9111891 49.47 µM -0.368391669727014 0.338414505957847 no 2232 0.356290603997442 3046 18891510
SGTC_3280 9140961 49.47 µM -0.368619713070819 0.338319398567099 no 2233 0.356205599942724 3033 4901226
SGTC_546 peri-Naphthalide 147 µM -0.369823413992996 0.337817556023089 no 2234 0.355757034168439 3080 223824 A penicillin ester.
SGTC_2196 6573537 42.6665 µM -0.370023728303274 0.337734069665423 no 2235 0.355682405298753 3165 2903087
SGTC_2249 haloperidol 116.36 µM -0.371698896595753 0.337036211271877 no 2236 0.355058523315082 3042 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_809 3998-0021 90 µM -0.372923498743729 0.336526408711113 no 2237 0.354602691054572 3204 715485
SGTC_1248 0469-0687 58.6 µM -0.37405866937048 0.336054104741927 no 2238 0.354180333654074 3164 4017482
SGTC_2804 7954240 19.48 µM -0.375286930413079 0.335543360588704 no 2239 0.35372354253306 3192 828705
SGTC_1698 5-fluorocytosine 1.055 µM -0.375822544660883 0.335320732745439 no 2240 0.353524413107877 3193 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_208 k072-0098 12.366 µM -0.375970839207559 0.335259104395003 no 2241 0.353469287587111 3078 5948901
SGTC_1897 st060201 15 µM -0.376239761377277 0.335147356844502 no 2242 0.353369329009969 3082 611878
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.378398213478063 0.334250965801649 no 2243 0.352567397572357 3111 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_32 0928-0142 34.1 µM -0.378716804722479 0.334118736808329 no 2244 0.35244908648547 3159 2244242
SGTC_1789 tunicamycin 25 nM -0.38279981410051 0.332425940756726 no 2245 0.350934099668935 3190 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.384256069197122 0.331823008112506 no 2246 0.350394332451634 3088 6708784 An antioxidant flavonoid
SGTC_50 0929-0078 56.389 µM -0.384624794772005 0.33167041383278 no 2247 0.350257710599376 3054 1377751
SGTC_3302 9125395 16.351 µM -0.385452371713449 0.331328029113025 no 2248 0.349951143647761 3106 17599668
SGTC_143 4032-1194 15.74 µM -0.385754441056143 0.331203092229832 no 2249 0.349839269666261 3022 1806963
SGTC_1896 st058441 89 µM -0.385841291624561 0.331167174023285 no 2250 0.349807106222935 3123 688759
SGTC_2396 5342950 42.78 µM -0.386475115601834 0.330905094748768 no 2251 0.349572414308656 3157 1886677
SGTC_1864 st057645 30.4 µM -0.386683375133966 0.330818999789401 no 2252 0.349495312652471 3177 688666
SGTC_707 0865-0008 204 µM -0.387611123947385 0.330435575112761 no 2253 0.349151917799181 3070 723043
SGTC_679 0422-0091 41.4 µM -0.387691754727569 0.330402260018463 no 2254 0.349122079131902 3076 627384 YHR062C RPP1
SGTC_91 0417-1751 58.384 µM -0.387873307694087 0.330327250730309 no 2255 0.349054896063495 3163 6795624
SGTC_1273 0849-0096 14.1 µM -0.389844280758348 0.329513375104901 no 2256 0.348325848926648 3140 5286025
SGTC_3283 9109332 35.8195 µM -0.391175844703582 0.328963987673583 no 2257 0.347833630891745 3103 17027281
SGTC_2370 9071495 200 µM -0.39130118299225 0.328912293585921 no 2258 0.347787312270356 3163 21791103
SGTC_3130 9127414 49.47 µM -0.394343352033086 0.327658597612343 no 2259 0.346663780337352 3177 1494646
SGTC_1032 k061-1018 98.7 µM -0.394686632201736 0.327517251388325 no 2260 0.346537084737846 3286 4005393
SGTC_2581 avocatin a 64 µM -0.394890681423507 0.327433245468072 no 2261 0.346461783718527 3114 6710728 A skin care supplement.
SGTC_2105 5350118 200 µM -0.395432061632939 0.327210404624861 no 2262 0.346262025640643 3135 2133313
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.396699837595889 0.32668880858882 no 2263 0.345794409977404 3103 641818 YHR062C RPP1
SGTC_2983 9022671 12.99 µM -0.397103668361015 0.326522733146874 no 2264 0.345645507459094 3282 6405161
SGTC_3294 9122953 26.2835 µM -0.398246817336256 0.326052799497839 no 2265 0.345224129323901 3103 16459826
SGTC_2640 pentamidine 10.38 µM -0.398687193524119 0.32587184021813 no 2266 0.345061852637868 3215 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1673 st016611 27.3 µM -0.39870574694218 0.325864217151979 no 2267 0.345055016410239 3264 5226799
SGTC_854 0422-0053 192 µM -0.399045577294281 0.325724603509524 no 2268 0.344929810821707 3152 3596728
SGTC_1390 3413-2614 145 µM -0.399257158602599 0.325637691195205 no 2269 0.344851865317456 3156 3421432
SGTC_2440 5628896 157.78 µM -0.399335366069884 0.3256055679208 no 2270 0.344823055741032 3095 5522048
SGTC_3070 9117005 49.47 µM -0.399586550463316 0.325502404113971 no 2271 0.344730532095372 3195 8779016
SGTC_1280 0880-0253 10.1 µM -0.401781397910951 0.324601528917613 no 2272 0.343922456754468 3116 6836607
SGTC_1689 st020265 53.493 µM -0.401976868371157 0.324521347705356 no 2273 0.34385052503589 3238 5758320 YPR016C TIF6
SGTC_3079 9117512 49.47 µM -0.402191153884137 0.324433457977962 no 2274 0.343771676007759 3165 7185044
SGTC_1983 st071813 46.9 µM -0.402307400166512 0.324385783371767 no 2275 0.343728904580584 3173 11838595
SGTC_349 k015-0014 24 µM -0.402908839621063 0.324139168659457 no 2276 0.343507644094394 3045 2196908
SGTC_806 3966-4455 5.86 µM -0.403363900438119 0.323952626419251 no 2277 0.34334026971987 3120 714982
SGTC_61 0978-8327 98.565 µM -0.404295966408524 0.323570684364746 no 2278 0.342997545628608 3228 6150059 YHR072W ERG7
SGTC_2529 gangaleoidin 93.61 µM -0.404787972339686 0.323369145034887 no 2279 0.342816685289281 3080 4565183
SGTC_2857 9024691 58.44 µM -0.404797544527746 0.323365224513794 no 2280 0.342813166930256 3193 16478292
SGTC_1724 st037281 8.293 µM -0.407548299922184 0.322239400234247 no 2281 0.341802663608595 3083 574124 YDL195W SEC31
SGTC_2332 7982454 138.89 µM -0.408618299728458 0.321801912042191 no 2282 0.341409899506062 3205 2981748
SGTC_1676 st018489 23.4 µM -0.408663656660672 0.321783372516049 no 2283 0.341393254158239 3119 3696235
SGTC_192 3455-0609 60.9 µM -0.408784419889788 0.321734013028833 no 2284 0.341348937278321 3242 3769639
SGTC_170 4197-0004 226 µM -0.409146175108577 0.32158617185091 no 2285 0.341216195868725 3232 218692
SGTC_2598 perillyl alcohol 100 µM -0.409420321519514 0.321474153227515 no 2286 0.341115614465128 3262 10819 An apoptosis inducer.
SGTC_1500 4488-1866 171 µM -0.409474811881404 0.321451889922289 no 2287 0.34109562387535 3254 2900003
SGTC_1838 st055369 84.5 µM -0.409537920330833 0.321426106298446 no 2288 0.341072472170981 3162 676036
SGTC_2813 7971799 71.43 µM -0.410479933479657 0.321041339207666 no 2289 0.340726960297446 3204 2234054
SGTC_3164 9100705 49.47 µM -0.411380204930655 0.320673801071247 no 2290 0.340396883281822 3254 17174235
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.411383655341568 0.320672392769943 no 2291 0.340395618452425 3193 6708739 YPR165W RHO1
SGTC_2198 6589944 200 µM -0.411968165788458 0.320433859374301 no 2292 0.340181378302602 3178 5290268
SGTC_1293 1000-1278 195 µM -0.412117189209903 0.320373056131787 no 2293 0.340126765115998 3253 678847
SGTC_121 0557-0495 61.343 µM -0.412142554392184 0.320362707330496 no 2294 0.340117469774054 3161 3104427
SGTC_1880 MG-132 525 µM -0.412158830596727 0.320356066836516 no 2295 0.340111505236253 3240 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2282 7944268 200 µM -0.412585440989474 0.32018203548977 no 2296 0.339955184915709 3321 2970414
SGTC_141 0443-0274 32.331 µM -0.413028909866389 0.320001168821454 no 2297 0.339792716405254 3294 1627241
SGTC_377 3970-0964 33.1 µM -0.413329927002114 0.319878424784911 no 2298 0.339682453226738 3133 16481235
SGTC_281 1672-3440 14.9 µM -0.413752119626283 0.319706302937349 no 2299 0.339527826339341 3230 6833000
SGTC_1511 0906-3109 28.5 µM -0.413894400290917 0.319648305905345 no 2300 0.339475722520768 3147 2882180
SGTC_2227 7312221 64.1025 µM -0.414226262100586 0.319513048165472 no 2301 0.339354205161113 3156 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_2037 5169046 200 µM -0.415523443376568 0.318984583239669 no 2302 0.338879378517226 3236 5718022
SGTC_1214 0358-0031 63.7 µM -0.416906237111741 0.318421645167339 no 2303 0.338373495636335 3343 4301366
SGTC_3175 9106517 49.47 µM -0.417204395023521 0.318300319355706 no 2304 0.338264455379058 3216 41468073
SGTC_37 0566-0070 1.56 µM -0.417344471292011 0.318243326532825 no 2305 0.338213232333515 3200 1626686
SGTC_2411 st077133 39.94 µM -0.41759503384932 0.318141390892097 no 2306 0.338121614166066 3385 1403142 YNL221C POP1
SGTC_2719 novobiocin 32.65 µM -0.419493049904958 0.317369674274551 no 2307 0.337427916501421 3259 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_871 0574-0004 149 µM -0.420506320324666 0.316958011979955 no 2308 0.337057806603922 3123 9551173
SGTC_519 k048-0011 62.8 µM -0.422480781410281 0.316156496842149 no 2309 0.336337062829702 3225 6836379
SGTC_1771 st048882 4.1505 µM -0.422989322808151 0.315950198565621 no 2310 0.336151525589126 3133 4580403
SGTC_2900 5328528 85.29 µM -0.423689409182428 0.315666290637693 no 2311 0.335896169995165 3166 795359
SGTC_3099 9120367 49.47 µM -0.42425001811334 0.31543902377057 no 2312 0.33569174321532 3134 24824940
SGTC_3240 9133527 49.47 µM -0.424865855598624 0.315189448095439 no 2313 0.335467233307486 3166 17617455
SGTC_1862 st057513 3.81 µM -0.425875026933971 0.314780651417025 no 2314 0.3350994565051 3108 5393163
SGTC_2158 5657123 3.6195 µM -0.427182565040887 0.31425132929911 no 2315 0.334623179636432 3215 2858827
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM -0.428248026017811 0.313820287901429 no 2316 0.334235277117648 3205 5379071
SGTC_159 3970-0959 50 µM -0.429625548138683 0.313263375966285 no 2317 0.333734024792038 3329 6615653
SGTC_179 1273-0063 6.77 µM -0.430413904188888 0.312944846599127 no 2318 0.333447291412905 3133 3108139
SGTC_312 4092-0653 6.84 µM -0.431336055400363 0.312572435426118 no 2319 0.333112018780905 3237 1148278
SGTC_2426 5582046 32.21 µM -0.433169692291942 0.311832488994264 no 2320 0.332445747627135 3318 2251934
SGTC_1429 4049-0205 9.46 µM -0.434894717867681 0.311137064243218 no 2321 0.33181942441917 3232 22774478
SGTC_2348 9022543 33.42 µM -0.434975379049521 0.311104563059283 no 2322 0.331790149397203 3255 3162678 YDL140C RPO21
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.435652308007594 0.310831863006836 no 2323 0.331544506532605 3286 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3274 9138298 49.47 µM -0.435809381709879 0.310768600888148 no 2324 0.331487518236351 3179 17015756
SGTC_2380 9035439 200 µM -0.436458458869269 0.310507241564684 no 2325 0.33125206633462 3313 6462575
SGTC_1001 4048-4355 44.4 µM -0.437350910590325 0.310148040476156 no 2326 0.330928439532593 3132 21824233
SGTC_1957 st077035 62.4 µM -0.438184059499364 0.309812871465891 no 2327 0.330626431490498 3280 705593
SGTC_727 3032-0951 202 µM -0.438303396017806 0.309764876291223 no 2328 0.330583182232717 3202 3652836
SGTC_3067 9117431 49.47 µM -0.441169286570606 0.308613238089187 no 2329 0.32954522321047 3187 17150885
SGTC_3285 9112818 20.8695 µM -0.441553426764 0.308459016664646 no 2330 0.329406196078072 3186 17017947 YPR165W RHO1
SGTC_266 formosanin C 406 nM -0.441880942171605 0.308327555174941 no 2331 0.329287681078911 3253 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2610 ononetin 44.17 µM -0.443482615545812 0.30768501333232 no 2332 0.328708345424992 3249 259632
SGTC_2619 obliquin 87.91 µM -0.443597523349983 0.307638938512172 no 2333 0.328666798327058 3159 6708593 A bioactive alkalod. YER133W GLC7
SGTC_42 0133-0086 60.653 µM -0.444244302939483 0.307379654578298 no 2334 0.328432982407943 3134 162923 Model of phenazepam hydroxylation.
SGTC_1368 1852-0141 284 µM -0.44461260210569 0.307232052131491 no 2335 0.328299869367271 3282 2838987
SGTC_1094 duloxetine 25.4 µM -0.445364661592211 0.30693074789682 no 2336 0.32802812292557 3165 60834 A selective serotonin reuptake inhibitor.
SGTC_2238 6671620 73.2395 µM -0.445990828316257 0.306679980631759 no 2337 0.327801935539979 3139 729941
SGTC_1933 st074711 15.9 µM -0.44740960192896 0.306112124971918 no 2338 0.327289672120978 3250 17250958
SGTC_890 0929-0006 47.2 µM -0.447787534107777 0.305960938347285 no 2339 0.32715327045198 3183 1378169
SGTC_3221 9128209 49.47 µM -0.447824372000668 0.305946203617112 no 2340 0.327139976311211 3216 16460723
SGTC_2086 5274770 176.623 µM -0.448033858750066 0.305862417316936 no 2341 0.327064380436998 3246 689278
SGTC_3270 9137563 49.47 µM -0.448426053740407 0.305705582363591 no 2342 0.326922871120584 3251 17015724
SGTC_3317 9138495 8.753 µM -0.44843662169518 0.305701356834397 no 2343 0.326919058402198 3255 17020139
SGTC_1123 mangostin 811.285 nM -0.44844911341861 0.305696362131962 no 2344 0.326914551647733 3236 5281650 An antioxidant.
SGTC_1046 2001-0062 216 µM -0.449057789792202 0.30545303220795 no 2345 0.326694984445865 3192 739778
SGTC_1284 0929-0043 16 µM -0.449310844296108 0.30535189415012 no 2346 0.326603718010913 3237 1239883
SGTC_1668 st014914 51.6 µM -0.450073267179127 0.30504726713985 no 2347 0.326328805929851 3281 2839556
SGTC_825 1988-2224 89.6 µM -0.450555260046588 0.304854755943062 no 2348 0.326155059088116 3195 1180859
SGTC_2136 5328288 199.296 µM -0.451256712595979 0.304574687574759 no 2349 0.325902269720773 3184 262395
SGTC_2947 9072639 7.68 µM -0.452808075786497 0.303955683000107 no 2350 0.325343473957536 3286 16488146
SGTC_2371 9071574 200 µM -0.452821319679937 0.30395040101111 no 2351 0.325338705239728 3288 45596039
SGTC_2000 st075254 36.4 µM -0.453274018833134 0.303769878119379 no 2352 0.325175719428624 3267 17234175
SGTC_109 0132-0036 33.701 µM -0.453441769728194 0.303702996226579 no 2353 0.325115332365988 3206 67274 A color developer.
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.453751870134467 0.30357937722116 no 2354 0.325003714339751 3221 16486 A toxic proline analog.
SGTC_970 1315-0089 19.5 µM -0.454401740968924 0.303320384407376 no 2355 0.324769849765084 3276 6811083 YLR033W RSC58
SGTC_90 0870-0863 4.608 µM -0.455303905649277 0.302961008814208 no 2356 0.324445308410061 3176 1738164
SGTC_2803 7707263 71.43 µM -0.455643539049855 0.302825765882779 no 2357 0.324323164479335 3166 2199229
SGTC_663 1486-0733 13.9 µM -0.455824712945394 0.30275363300986 no 2358 0.324258015802894 3192 722445 YPR165W RHO1
SGTC_2390 9097792 176.6 µM -0.457212824718469 0.302201223464775 no 2359 0.323759040612399 3238 4497149
SGTC_3094 9117742 49.47 µM -0.457999638230034 0.301888306113623 no 2360 0.323476350588894 3178 17149698
SGTC_2193 5925765 200 µM -0.459306955778774 0.301368705427791 no 2361 0.323006876724001 3290 877370
SGTC_1009 4106-0057 9.87 µM -0.459697348090509 0.30121361991907 no 2362 0.32286673664187 3349 2928005
SGTC_1614 st002383 48.6 µM -0.460098421891851 0.301054328578976 no 2363 0.322722788388583 3294 1947235
SGTC_19 0279-0214 38.434 µM -0.46061087327395 0.30085085754431 no 2364 0.322538904576936 3248 3566274 YBR002C RER2
SGTC_495 decylubiquinone 155 µM -0.461378736265439 0.300546090392772 no 2365 0.322263452224789 3266 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_1519 esterone 74 µM -0.461880276865258 0.30034710270639 no 2366 0.322083589284362 3167 698 A steroid.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.463448034559967 0.299725474570395 no 2367 0.321521627424065 3302 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_775 4577-0580 57.3 µM -0.464459926659032 0.299324561168172 no 2368 0.321159131943091 3408 2006902
SGTC_1421 4029-0249 71.4 µM -0.465305302544456 0.298989808391888 no 2369 0.320856419027208 3358 2894095
SGTC_2552 juarezic acid 87.02 µM -0.466187214776981 0.298640769230058 no 2370 0.320540750027876 3242 1549512
SGTC_1199 1638-0010 4.46 µM -0.466670638731736 0.298449520574916 no 2371 0.320367769763526 3209 3111136
SGTC_2663 amphotericin b 100 µM -0.467009206842773 0.298315611923125 no 2372 0.320246645499662 3296 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1579 chlormadinone acetate 49.4 µM -0.467607168952997 0.298079175981561 no 2373 0.320032768651172 3327 45114258 A steroidal progestin.
SGTC_177 1327-0068 8.361 µM -0.468888708428684 0.297572739394259 no 2374 0.319574593884964 3323 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2290 7904846 200 µM -0.469270362622239 0.297421993877564 no 2375 0.31943819840553 3272 2962154
SGTC_2797 7859098 81.82 µM -0.470108996264105 0.297090873510181 no 2376 0.31913857355404 3214 972681
SGTC_691 1548-0686 185 µM -0.470369554267432 0.29698803090415 no 2377 0.319045506106326 3244 46495133
SGTC_840 0245-0196 390 µM -0.470629225788593 0.296885554398931 no 2378 0.318952766644239 3371 3827528
SGTC_868 0527-0199 213 µM -0.471139241158518 0.296684329566423 no 2379 0.318770652011309 3222 2849450
SGTC_1873 rapamycin 2 nM -0.471611080257309 0.296498222690571 no 2380 0.318602208201103 3254 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_3140 9094243 49.47 µM -0.472798818050503 0.29602998182382 no 2381 0.318178358706405 3347 19291112
SGTC_3088 9117578 49.47 µM -0.47324848646234 0.29585279804461 no 2382 0.318017954612049 3342 678341
SGTC_2069 5228469 200 µM -0.476788629596252 0.294459572536335 no 2383 0.316756321620568 3315 2835210
SGTC_367 0335-0881 7.1 µM -0.476920465915939 0.294407746810486 no 2384 0.316709378930982 3366 23828853
SGTC_704 1310-0270 142 µM -0.478753843487221 0.293687470888963 no 2385 0.316056878109896 3281 5718033
SGTC_2417 cerulenin 830 nM -0.479317217165103 0.29346630316486 no 2386 0.315856487788589 3389 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_943 3253-1379 105 µM -0.479573513631134 0.293365712525739 no 2387 0.315765341810109 3376 668464
SGTC_578 3460-0051 92 µM -0.480901295467575 0.292844843771293 no 2388 0.315293326007718 3389 2876744
SGTC_2172 5754775 163.918 µM -0.481160082733333 0.292743375448141 no 2389 0.315201364273401 3221 2263357
SGTC_405 ebelactone b 50 µM -0.482484624924171 0.29222428934371 no 2390 0.314730858992629 3280 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1367 1812-0510 76.9 µM -0.482814139686955 0.29209521954621 no 2391 0.314613855076346 3290 1142582 YDR527W RBA50
SGTC_2582 agaric acid 100 µM -0.484781401546733 0.291325202488165 no 2392 0.31391570845645 3343 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_3170 9103054 49.47 µM -0.484830695287009 0.291305920319091 no 2393 0.313898223513367 3311 16432970
SGTC_2701 st077767 14.721 µM -0.485026004103278 0.291229527476248 no 2394 0.313828949787897 3294 5721188
SGTC_451 chloral hydrate 100 µM -0.485323084625164 0.291113345712937 no 2395 0.313723591425514 3343 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_1695 st026914 34.495 µM -0.485713288358677 0.290960778372697 no 2396 0.313585230385109 3245 3289191
SGTC_969 1313-0238 134 µM -0.485928945442491 0.290876473768836 no 2397 0.313508772508416 3220 5212874
SGTC_1106 tegaserod maleate 11.7 µM -0.486701695603023 0.29057448429519 no 2398 0.313234871723748 3288 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_1942 st076330 65.2 µM -0.486792211274041 0.29053912052225 no 2399 0.313202795240122 3395 24208414
SGTC_1521 st012942 49.4 µM -0.486916560478174 0.290490541533676 no 2400 0.313158731305458 3398 24207259
SGTC_524 r073-0010 27.8 µM -0.48713051474604 0.290406965804909 no 2401 0.313082921488706 3213 2772106
SGTC_2414 st077232 92.9 µM -0.487594550762463 0.290225740771601 no 2402 0.31291852805981 3181 729801
SGTC_263 alizarin 107.927 µM -0.487778928187738 0.290153748560176 no 2403 0.312853219235058 3295 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_387 norethindrone acetate 66.7 µM -0.488523454094945 0.289863125311186 no 2404 0.312589558467328 3289 541197
SGTC_3216 9129716 49.47 µM -0.488571304842316 0.28984445159925 no 2405 0.31257261624392 3248 8056934
SGTC_2905 7799065 20.05 µM -0.489173502486026 0.289609492752815 no 2406 0.312359433650412 3366 1296806
SGTC_908 3448-7491 47.7 µM -0.489262172835411 0.289574903885893 no 2407 0.312328048967333 3270 1203031
SGTC_1406 3909-7906 11.9 µM -0.489456301873846 0.289499184065058 no 2408 0.312259342157499 3314 X1406
SGTC_724 3910-0327 137 µM -0.490348342934259 0.289151364007412 no 2409 0.311943711898451 3331 2885483
SGTC_2834 9001755 58.44 µM -0.491323321663617 0.288771430216215 no 2410 0.311598893745797 3222 2989575
SGTC_3001 9076041 71.4286 µM -0.49174795042211 0.288606032610484 no 2411 0.311448768022536 3288 16004211
SGTC_272 doxorubicin 8.13 µM -0.49377005605052 0.287819012973599 no 2412 0.310734291414474 3337 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1049 3226-0134 66 µM -0.494034662612075 0.287716101042539 no 2413 0.310640849898433 3342 5702385
SGTC_929 2805-0021 398 µM -0.494319311455179 0.287605413596486 no 2414 0.310540344412933 3348 3098024
SGTC_1616 st002734 56.1 µM -0.494978615954101 0.287349116335694 no 2415 0.310307607626196 3235 4026101
SGTC_1394 3474-0001 65.7 µM -0.495839650022337 0.287014561754533 no 2416 0.310003773957013 3291 5017666 YIL048W NEO1
SGTC_2586 curcumin 80 µM -0.496258329580785 0.286851950603705 no 2417 0.309856081072737 3358 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2152 5568786 200 µM -0.496926645364785 0.28659247362738 no 2418 0.309620390409596 3321 5399883
SGTC_2818 7996756 12.99 µM -0.498442542847074 0.286004331780672 no 2419 0.309086078719897 3241 2241621
SGTC_1947 st076332 61.6 µM -0.498702143468021 0.285903668814105 no 2420 0.308994617171234 3386 24208416
SGTC_22 0964-0034 14.468 µM -0.499170389698151 0.28572214384397 no 2421 0.308829676300384 3329 138402
SGTC_3123 9126162 49.47 µM -0.500215359074428 0.285317238491444 no 2422 0.308461722345673 3264 25239884
SGTC_1949 st076024 69.1 µM -0.500870845252846 0.285063389901373 no 2423 0.308231011085608 3219 2921930
SGTC_1522 st012842 45.6 µM -0.501728778932455 0.284731302730776 no 2424 0.307929158885779 3276 3491067 YOR116C RPO31
SGTC_579 4491-1009 110 µM -0.501944922487307 0.284647667465493 no 2425 0.307853132219891 3442 1271041
SGTC_197 4544-0043 41.561 µM -0.502449870905425 0.284452326859004 no 2426 0.307675553033855 3345 896523
SGTC_1352 1496-0991 99 µM -0.502601209864957 0.284393793465517 no 2427 0.30762233924281 3298 3000039
SGTC_1185 1319-0113 81.3 µM -0.503364453335581 0.284098681405489 no 2428 0.307354029341374 3371 4672763
SGTC_2473 5854593 8.94 µM -0.503469649833746 0.284058018120033 no 2429 0.307317056740741 3209 2872951
SGTC_681 1642-0006 26.6 µM -0.504055186504522 0.283831732155119 no 2430 0.307111298481311 3382 4446530
SGTC_737 1950-0117 57.9 µM -0.504171034128522 0.283786972016509 no 2431 0.307070596686348 3383 5393513
SGTC_2168 5727979 200 µM -0.505501911286155 0.283273002535752 no 2432 0.306603178187011 3328 695210
SGTC_2664 lyso-paf C-16 73.48 µM -0.507236933150193 0.282603628157675 no 2433 0.305994291813378 3282 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.509595026402284 0.281695092500013 no 2434 0.305167604506502 3261 23665772 A membrane-active detergent.
SGTC_2969 9091408 28.7 µM -0.511889245192079 0.280812520360332 no 2435 0.304364262762079 3242 4286311
SGTC_2888 9058547 12.99 µM -0.5138339891962 0.280065437625158 no 2436 0.303684031071597 3295 16476514
SGTC_463 ikarugamyin 104 µM -0.514052314223127 0.279981627203562 no 2437 0.303607707823483 3368 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2824 7998404 51.95 µM -0.514206278170531 0.279922530969369 no 2438 0.303553889420761 3288 837851
SGTC_844 0330-0132 15.3 µM -0.514996166001761 0.279619442183795 no 2439 0.303277849584829 3419 2828079
SGTC_3161 9100388 49.47 µM -0.515319793400627 0.279495308754509 no 2440 0.303164784859857 3348 25236368
SGTC_1959 st077091 55.8 µM -0.515444772913795 0.279447377654534 no 2441 0.303121126191662 3294 821356 YKL052C ASK1
SGTC_1306 1185-0270 9.02 µM -0.517726121956681 0.27857315594179 no 2442 0.302324685012086 3388 1548076
SGTC_2721 ifenprodil 61.44 µM -0.518668451647419 0.278212440729705 no 2443 0.30199598272809 3427 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1326 1431-2094 10.8 µM -0.518790579661799 0.278165707916448 no 2444 0.301953393936777 3265 616278
SGTC_94 0334-0113 514.748 µM -0.519537638978145 0.277879925798774 no 2445 0.301692936267067 3353 6795178
SGTC_771 0250-0039 27.3 µM -0.522934070722398 0.276582455470085 no 2446 0.300510066961141 3299 3005115
SGTC_1622 st003707 19.4 µM -0.523610106119212 0.276324558102286 no 2447 0.300274875467111 3409 10140899
SGTC_893 0958-0369 48.9 µM -0.523905700599343 0.276211830320627 no 2448 0.300172064831292 3399 6819948
SGTC_1962 st076595 64.5 µM -0.525785662671256 0.275495417472275 no 2449 0.29951856861284 3339 279619
SGTC_2789 5281112 71.43 µM -0.525863605444358 0.275465734912616 no 2450 0.299491488744857 3336 765948
SGTC_3181 9108277 49.47 µM -0.531351185057551 0.273379890658442 no 2451 0.297587720973877 3311 17097298
SGTC_1242 0402-0103 60.1 µM -0.53148147030286 0.273330464079854 no 2452 0.29754258922112 3357 432868
SGTC_1564 D-Arginine 115 µM -0.533024802658773 0.272745303891785 no 2453 0.297008205628076 3347 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2874 9043904 71.43 µM -0.533469105536111 0.272576960108004 no 2454 0.296854445805715 3345 4463428
SGTC_199 4063-0024 41.6 µM -0.533699650502749 0.272489628288143 no 2455 0.296774675506298 3432 306215
SGTC_343 4130-2827 29.8 µM -0.534617274004645 0.272142164753908 no 2456 0.296457268148859 3361 1118244
SGTC_1240 0356-0016 42.1 µM -0.53548683405932 0.271813104098581 no 2457 0.296156629664727 3340 4305613
SGTC_617 3770-0098 35 µM -0.535549406734167 0.271789432860209 no 2458 0.296135001415024 3349 5962639
SGTC_1497 4476-2978 41.3 µM -0.536543584035798 0.271413473350348 no 2459 0.295791461234926 3418 1528379
SGTC_637 1181-0519 7.26 µM -0.538143111991523 0.270809137870493 no 2460 0.295239125381614 3424 6252091 YGR060W ERG25
SGTC_2120 5538279 151.968 µM -0.538298031381354 0.27075064174725 no 2461 0.295185655117404 3413 2058197
SGTC_277 nystatin 15.5 µM -0.53847431050834 0.270684088059376 no 2462 0.295124817985852 3292 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3145 9085516 49.47 µM -0.538826604566452 0.270551104912068 no 2463 0.295003252204736 3392 25236195
SGTC_2827 7993847 71.43 µM -0.53941338094152 0.2703296823978 no 2464 0.294800825056875 3414 2985692
SGTC_139 0099-0334 718.624 µM -0.541618601403466 0.269498344070275 no 2465 0.29404063739932 3432 97690
SGTC_89 0302-0250 142.109 µM -0.541900230359057 0.269392266100227 no 2466 0.293943619035689 3471 4203518 YLR208W SEC13
SGTC_828 2074-0507 139 µM -0.54323565157643 0.268889553342669 no 2467 0.293483781396553 3452 X828
SGTC_767 0929-0023 86 µM -0.543468633824535 0.26880189660364 no 2468 0.293403590664161 3468 1204563
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.543623414075193 0.268743670351402 no 2469 0.293350322082276 3448 6708760
SGTC_1408 3909-7976 48.8 µM -0.543655401788145 0.268731637793317 no 2470 0.293339313871565 3411 24152374
SGTC_3051 9093778 49.47 µM -0.545442033053896 0.268060005238655 no 2471 0.292724769046665 3397 17217378
SGTC_810 3825-7150 143 µM -0.545527705366594 0.268027820444743 no 2472 0.292695315501077 3478 22330411 YGL099W LSG1
SGTC_1028 k015-0029 4.8 µM -0.545907044099012 0.267885336422127 no 2473 0.292564918024872 3424 4588309
SGTC_1363 1636-0063 10.4 µM -0.546002651521315 0.267849431186984 no 2474 0.292532057286756 3387 6072185
SGTC_593 1203-0218 61.7 µM -0.546132586800359 0.267800638059058 no 2475 0.292487400646379 3472 3666956
SGTC_2691 st077356 60.2 µM -0.546708203298106 0.267584537169892 no 2476 0.292289608746066 3486 2839272
SGTC_554 4483-2211 187 µM -0.547344979457304 0.267345577870067 no 2477 0.292070873821957 3403 747107
SGTC_2864 9034755 47.6 µM -0.547556367287639 0.267266275391936 no 2478 0.291998278183014 3456 4930451
SGTC_3248 9135562 49.47 µM -0.54822171030028 0.26701674841508 no 2479 0.291769838325371 3424 17650701
SGTC_563 tetrahydrosecaminediol 614 µM -0.548477058230558 0.266921015230586 no 2480 0.291682188905827 3472 334274 A psychoactive constituent of the cannabis plant.
SGTC_1415 3966-0071 78.1 µM -0.548535396787708 0.266899145797413 no 2481 0.291662165634604 3438 2893185
SGTC_129 0088-0017 176.636 µM -0.548805467517717 0.266797915909468 no 2482 0.291569478865822 3435 182446
SGTC_1407 3909-7909 12.3 µM -0.548891716656367 0.266765591464012 no 2483 0.291539881536038 3441 4411780
SGTC_836 0330-0104 1.35 µM -0.549002349877035 0.266724131252131 no 2484 0.291501918594718 3428 46494820
SGTC_3192 9110362 49.47 µM -0.549217371739242 0.266643560325259 no 2485 0.291428142087284 3491 16649480
SGTC_108 0509-0257 621.132 µM -0.551047305799652 0.265958363357362 no 2486 0.290800623189189 3388 536624
SGTC_360 0957-0399 1.01 µM -0.551408635567742 0.26582317327389 no 2487 0.290676791121914 3449 6752301 YPR165W RHO1
SGTC_1030 k029-0042 36.7 µM -0.551590208140724 0.265755251774849 no 2488 0.290614573324889 3401 6080581
SGTC_3256 9138902 49.47 µM -0.553227670107534 0.265143118234964 no 2489 0.290053761000446 3418 17228773
SGTC_2129 girgensonine 121.053 µM -0.553399299370187 0.265078999435068 no 2490 0.289995009290354 3386 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3353 9151644 39.2805 µM -0.553610152301699 0.26500023788863 no 2491 0.289922838268343 3462 4909158
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.5546959211023 0.264594850513691 no 2492 0.289551333304476 3408 65057 A dermal irritant. YDR527W RBA50
SGTC_2321 7390090 138.78 µM -0.555008421963124 0.264478232322417 no 2493 0.289444449936434 3363 649046
SGTC_796 1234-0020 70.7 µM -0.555275295474469 0.264378661927462 no 2494 0.289353186974683 3427 46495034
SGTC_1014 4130-3005 69.3 µM -0.557158519171778 0.263676574801486 no 2495 0.288709564032775 3374 743608
SGTC_3016 9080866 49.47 µM -0.558738745845262 0.263088183132277 no 2496 0.288170016094914 3397 17066299
SGTC_467 ro 31-8220 72.8 µM -0.55907225259561 0.262964088902696 no 2497 0.288056205355163 3361 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_2636 apigenin dimethyl ether 100 µM -0.55920979149189 0.262912920893075 no 2498 0.288009275742131 3483 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.560463472613249 0.262446754029823 no 2499 0.287581673982529 3480 364106
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.561219578988086 0.262165809311499 no 2500 0.287323928675399 3523 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_344 k064-0035 6.43 µM -0.56143935845619 0.262084175273272 no 2501 0.287249029662982 3348 5088750
SGTC_2563 tomatine 8.54 µM -0.564413878202743 0.260980613935147 no 2502 0.286236248045158 3524 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.564426717280706 0.260975855758778 no 2503 0.286231880199879 3454 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1719 st032227 49.2 µM -0.56488201123978 0.260807152161777 no 2504 0.286077009982397 3412 3125804
SGTC_1821 st053465 65.6 µM -0.564898921036908 0.260800887524431 no 2505 0.286071258808367 3420 675086
SGTC_2714 st079313 56.9 µM -0.565139126800484 0.260711905936037 no 2506 0.285989568602069 3445 2939799
SGTC_92 0063-0024 660.874 µM -0.566521699268332 0.260200051063896 no 2507 0.285519593116731 3482 3594437
SGTC_40 0327-0103 19.753 µM -0.566738660146072 0.260119775021534 no 2508 0.285445875364954 3371 409036
SGTC_1615 st002656 86.5 µM -0.567367477818328 0.259887183128411 no 2509 0.285232270430211 3499 1584458
SGTC_471 1-acyl-paf 4 µM -0.568764597660214 0.259370790009571 no 2510 0.284757951454055 3388 16759367
SGTC_372 0155-0182 15.9 µM -0.568933947171602 0.2593082323351 no 2511 0.284700483273519 3452 771486
SGTC_269 exalamide 29 µM -0.56979662083034 0.258989681922174 no 2512 0.284407823864994 3392 3316 A derivative of salicylamide.
SGTC_1848 st056003 16.4 µM -0.56998603868087 0.258919764697245 no 2513 0.284343583687924 3511 146492
SGTC_1950 st077106 7.18 µM -0.571089543293347 0.258512637332182 no 2514 0.283969473208752 3414 13831864
SGTC_1160 4092-0570 10.5 µM -0.571535521386235 0.258348192151517 no 2515 0.283818344433723 3460 4994975
SGTC_2233 sulbentine 40.3845 µM -0.572149760776376 0.258121792874792 no 2516 0.28361025994531 3446 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_3187 9109394 49.47 µM -0.572560347315993 0.257970514321001 no 2517 0.283471207240863 3407 17098090
SGTC_2141 5621638 7.665 µM -0.572677905327781 0.257927209131289 no 2518 0.283431400070196 3487 2856238
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.57537731958394 0.256933856578819 no 2519 0.282518069852355 3383 6708514
SGTC_574 1315-0397 40 µM -0.578102937418997 0.255932884759998 no 2520 0.281597312001235 3511 6794277
SGTC_1847 st056231 15 µM -0.580068890847324 0.255212161739576 no 2521 0.280934080750615 3488 5393180
SGTC_3236 9132701 49.47 µM -0.581341807859876 0.254746074103689 no 2522 0.280505054341543 3450 24282524
SGTC_2335 9018011 154.17 µM -0.583156879001583 0.254082244496637 no 2523 0.279893848271251 3464 6458208
SGTC_1025 k007-0731 70 µM -0.584611212202896 0.253551003856218 no 2524 0.279404583443445 3393 6256118
SGTC_2070 5230947 200 µM -0.58473723278848 0.25350499838836 no 2525 0.27936220733326 3553 2835538
SGTC_1346 1488-2224 62.4 µM -0.586505362823393 0.252859982077296 no 2526 0.27876797937216 3511 3722427
SGTC_1759 st043059 70 µM -0.586515961658418 0.25285611821391 no 2527 0.278764419202574 3404 669426
SGTC_3008 9078912 71.4286 µM -0.586814502368861 0.252747296330218 no 2528 0.278664147881356 3485 16648731
SGTC_3217 9129673 49.47 µM -0.587685883137819 0.252429808054674 no 2529 0.278371576377059 3523 17248312
SGTC_21 0849-0113 22.993 µM -0.589186655373434 0.251883493625314 no 2530 0.277868034005673 3465 1560156
SGTC_1932 st074806 40.9 µM -0.589200124961334 0.251878593223468 no 2531 0.2778635166742 3609 17251235
SGTC_934 2950-0684 338 µM -0.589443972667651 0.251789887129676 no 2532 0.277781743021094 3525 1121253
SGTC_1624 st003710 6.25 µM -0.589811702720323 0.251656146733548 no 2533 0.277658447992953 3509 24207033
SGTC_2477 5967686 25.23 µM -0.590519964622739 0.251398663467793 no 2534 0.277421052489423 3468 776118
SGTC_2699 st077704 54.6 µM -0.590961925025033 0.25123806268514 no 2535 0.277272966321499 3477 645852
SGTC_2904 7225135 42.03 µM -0.591065539147046 0.251200418953475 no 2536 0.27723825428555 3558 4446116
SGTC_2232 chlorophetanol 41.5365 µM -0.591725001694315 0.250960901545208 no 2537 0.277017375857014 3532 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1744 st037937 38.9 µM -0.592684375364432 0.250612672061256 no 2538 0.27669619997571 3537 1016152
SGTC_2040 5100729 123 µM -0.593040531746916 0.250483461071601 no 2539 0.276577013602428 3464 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_1925 st057770 10.1 µM -0.593046879810825 0.250481158359655 no 2540 0.276574889475377 3389 5989122
SGTC_2757 clomiphene 4.22 µM -0.59359446098625 0.250282569674626 no 2541 0.276391693320006 3586 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_654 1124-0271 80.9 µM -0.594283599662965 0.250032761688245 no 2542 0.276161222976789 3469 5403748
SGTC_1650 st011916 45.8 µM -0.594701150244621 0.24988146688747 no 2543 0.276021626415032 3520 242528
SGTC_2094 5332512 191.667 µM -0.594836156922701 0.249832559120156 no 2544 0.275976498056773 3533 755774
SGTC_313 3474-0040 5.03 µM -0.597126174034491 0.249003748056451 no 2545 0.275211572039261 3481 1043375 YIL048W NEO1
SGTC_1170 0310-0127 64.8 µM -0.59737349540427 0.248914324253474 no 2546 0.275129022683527 3458 774975
SGTC_1505 k297-0037 20.6 µM -0.598066404851345 0.248663880555147 no 2547 0.274897812725436 3428 4089396
SGTC_665 3914-0008 307 µM -0.599411780835981 0.248177994280089 no 2548 0.274449161429073 3465 1069549
SGTC_2830 7992007 71.43 µM -0.599687040650925 0.248078645866102 no 2549 0.274357413294961 3461 1952075
SGTC_2345 9052315 157.45 µM -0.600402306777906 0.247820586975577 no 2550 0.274119075415874 3501 6469265
SGTC_1254 0550-0035 264 µM -0.601017464129615 0.247598760730355 no 2551 0.273914177196498 3532 15121435
SGTC_2655 perillic acid 100 µM -0.602199575709007 0.247172788243649 no 2552 0.273520649041162 3466 5702197 An apoptosis inducer.
SGTC_768 0384-0033 77.3 µM -0.603273057775638 0.246786300092766 no 2553 0.273163526557606 3443 3965305 YMR134W ERG29
SGTC_653 0203-0016 55.2 µM -0.604634932375114 0.246296447304322 no 2554 0.272710795337984 3491 295302
SGTC_3066 9117245 49.47 µM -0.605126964268157 0.246119596578562 no 2555 0.272547319611536 3507 17176980
SGTC_307 1501-1223 22.3 µM -0.605236210947774 0.246080339352609 no 2556 0.272511029418863 3512 2830329
SGTC_797 k781-0471 270 µM -0.60583398433902 0.245865592078997 no 2557 0.272312500094728 3461 23738129
SGTC_1769 st044406 64.4 µM -0.605941768172447 0.245826881950749 no 2558 0.272276711148319 3466 670903
SGTC_469 w7 172 µM -0.605960831725426 0.245820035693227 no 2559 0.272270381458274 3536 45115570 A P450 inhibitor.
SGTC_3239 9133757 49.47 µM -0.609001474868089 0.244729366525129 no 2560 0.271261730653417 3517 17036923
SGTC_2750 bromebric acid 70.15 µM -0.609234812268587 0.24464577690232 no 2561 0.271184404325944 3547 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.609657434684315 0.244494417913159 no 2562 0.271044378297945 3454 688803
SGTC_805 3852-0218 479 µM -0.610516047680755 0.244187067653747 no 2563 0.270760008122502 3481 6615355
SGTC_2108 5365811 200 µM -0.610898492591731 0.244050234251303 no 2564 0.270633391424422 3533 780283
SGTC_3254 9136651 49.47 µM -0.610943189270573 0.244034245108812 no 2565 0.270618595547882 3499 16454030
SGTC_413 propylparaben 100 µM -0.611781270341026 0.243734546779249 no 2566 0.270341241622648 3474 7175 A pharmaceutical preservative.
SGTC_2377 9073351 62.6 µM -0.611791328750427 0.243730951092627 no 2567 0.270337913763264 3466 7337946 YHR072W ERG7
SGTC_99 0109-0120 622.8 µM -0.612282916464767 0.243555252907459 no 2568 0.270175295237213 3594 759414
SGTC_88 0180-0332 8.668 µM -0.613887468367559 0.242982246946924 no 2569 0.269644845885078 3559 3101745
SGTC_3323 9138564 53.9225 µM -0.614099410193749 0.242906614377314 no 2570 0.269574818994027 3565 43912313 YNL103W MET4
SGTC_3106 9121286 49.47 µM -0.615705831456379 0.242333768764724 no 2571 0.269044343931752 3602 15943471
SGTC_2387 9077560 195.08 µM -0.616024435789523 0.242220242350201 no 2572 0.268939196178933 3481 5303272
SGTC_2326 6164455 177.58 µM -0.618166644058058 0.241457670935742 no 2573 0.268232747630936 3507 2888790
SGTC_2378 9074213 121.43 µM -0.618334311927938 0.241398040532642 no 2574 0.268177494240883 3543 657714
SGTC_3331 9141060 1.957 µM -0.618498892540147 0.241339515881637 no 2575 0.268123263798783 3496 4906567 YPR165W RHO1
SGTC_3102 9121669 49.47 µM -0.619107816932482 0.241123050204665 no 2576 0.267922667029359 3522 41905072
SGTC_1310 1188-0297 994 nM -0.620324617123343 0.240690807998675 no 2577 0.267522045473078 3521 1588352
SGTC_26 0302-0163 425.158 µM -0.620679986254466 0.240564650341971 no 2578 0.267405100095721 3531 3100915
SGTC_3319 9138450 16.7555 µM -0.620765707597764 0.240534224266039 no 2579 0.267376894655315 3477 2029690
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -0.623970851043347 0.239398090557306 no 2580 0.266323364146649 3499 6857784
SGTC_3036 9090181 49.47 µM -0.624486262980701 0.239215665378853 no 2581 0.266154144547676 3573 25236586
SGTC_2401 5128683 200 µM -0.624868409833348 0.239080457168667 no 2582 0.266028713580923 3483 708373
SGTC_2607 solasodine 47.35 µM -0.627507558936824 0.238147835464955 no 2583 0.265163291425022 3545 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_308 4092-1169 104 µM -0.628056417332312 0.237954130759638 no 2584 0.264983491119117 3534 2268590 YDL196W YDL196W
SGTC_787 4152-0075 138 µM -0.629375495829873 0.237488951184929 no 2585 0.264551628204847 3528 9566539
SGTC_517 1365-0151 113 µM -0.62938576723592 0.237485330882314 no 2586 0.264548266778473 3607 768657
SGTC_2800 7887935 81.82 µM -0.63030448135111 0.23716163963623 no 2587 0.264247695779134 3545 2961002
SGTC_2234 tolnaftate 200 µM -0.630332830709505 0.237151655141681 no 2588 0.264238423631198 3533 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1217 1183-1422 255 µM -0.630353657451444 0.237144320220134 no 2589 0.264231611990641 3578 2849664
SGTC_2173 5763948 167 µM -0.631874923204362 0.236608886384258 no 2590 0.263734305367148 3569 2867177
SGTC_666 0272-0154 136 µM -0.632205218386308 0.236492721652571 no 2591 0.263626393927885 3560 6870312
SGTC_3043 9092303 49.47 µM -0.633197258544546 0.236144010162869 no 2592 0.263302417875008 3524 25236084
SGTC_1225 1216-0074 20.6 µM -0.633888883498187 0.235901065120633 no 2593 0.263076670429279 3539 4241466
SGTC_165 k038-0023 64.381 µM -0.63405771520628 0.235841781035032 no 2594 0.26302157852362 3550 46368543
SGTC_2313 7726885 200 µM -0.637268170912341 0.234716016183255 no 2595 0.261975089877096 3543 726423
SGTC_1985 st071382 65.5 µM -0.638653991338439 0.234230989849693 no 2596 0.261524024694777 3614 6123237
SGTC_364 0083-0097 67.7 µM -0.638823320018296 0.234171764197008 no 2597 0.26146893792313 3588 5207356
SGTC_399 oxolinic acid 75 µM -0.638900750840147 0.234144684182453 no 2598 0.261443749763379 3536 4628 A DNA gyrase inhibitor.
SGTC_1399 3562-5772 25 µM -0.639086770796844 0.234079634190399 no 2599 0.261383242772215 3534 23847490
SGTC_2028 5153890 36.43 µM -0.639226078415923 0.234030925759767 no 2600 0.261337934683584 3560 2830968 YPR165W RHO1
SGTC_1144 3486-0183 12.5 µM -0.639974287093826 0.233769413235429 no 2601 0.261094658057131 3574 6744069
SGTC_1036 k216-0215 33.5 µM -0.640399768558058 0.233620772006096 no 2602 0.260956366646247 3585 622330
SGTC_2382 9035899 200 µM -0.641266087978161 0.233318286823957 no 2603 0.26067490907474 3615 6462679
SGTC_590 k048-0076 22.4 µM -0.641284973526503 0.23331169514345 no 2604 0.260668775110075 3592 6832814
SGTC_1468 k284-1086 134 µM -0.641503502200313 0.233235428930935 no 2605 0.260597803111171 3601 15996457
SGTC_723 4182-0001 115 µM -0.641643789247279 0.23318647623423 no 2606 0.260552247046687 3519 744821 YLR208W SEC13
SGTC_1307 1187-1599 12.2 µM -0.644421067729016 0.232218529136345 no 2607 0.259651213319437 3535 1538471
SGTC_1778 st046819 58.9 µM -0.644439154309502 0.232212232872648 no 2608 0.259645350757864 3595 671715
SGTC_450 aminopyrene 156 nM -0.645634051886831 0.231796478074582 no 2609 0.25925818958498 3561 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_2253 7938677 135.83 µM -0.646100084620907 0.231634438287026 no 2610 0.259107270293102 3630 2301972
SGTC_1664 st014217 9.02 µM -0.646551265031285 0.231477622821688 no 2611 0.258961204040253 3641 3982782
SGTC_1179 1021-1431 9.29 µM -0.647857904195213 0.231023812134134 no 2612 0.258538429880929 3559 2840958
SGTC_1290 0986-0249 10.2 µM -0.648730471037266 0.230721036477746 no 2613 0.258256302681089 3554 53329
SGTC_2565 isoliquiritigenin 100 µM -0.649146977963363 0.230576589173672 no 2614 0.258121689704744 3548 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_3147 9097027 49.47 µM -0.650285555908397 0.230181980969054 no 2615 0.257753892700194 3599 25236841
SGTC_734 2023-0417 80 µM -0.650573348553832 0.230082297673931 no 2616 0.257660969581706 3567 3935732
SGTC_2958 9077254 16.72 µM -0.651028257118036 0.229924779391713 no 2617 0.257514123193781 3631 16457351
SGTC_2111 5486399 200 µM -0.652192144903624 0.229522042320816 no 2618 0.257138613334677 3615 689674
SGTC_1605 st000082 49.1 µM -0.652208042946416 0.229516543900167 no 2619 0.257133486056276 3597 1114022
SGTC_1780 st038448 24.544 µM -0.653101824951929 0.229207543491367 no 2620 0.256845317918929 3630 728868 YDL195W SEC31
SGTC_47 0149-0135 24.25 µM -0.653365529371002 0.229116419570373 no 2621 0.256760327953324 3530 5239155
SGTC_1105 epirubicin 18.1 µM -0.654138576569494 0.228849407721752 no 2622 0.256511265001089 3557 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3117 9124945 49.47 µM -0.655123553964831 0.228509447998148 no 2623 0.256194104099879 3530 17592065
SGTC_2174 5790901 200 µM -0.655358718271959 0.228428324257406 no 2624 0.256118411875315 3597 786020
SGTC_3311 9131146 2.8755 µM -0.655581724164593 0.22835140970987 no 2625 0.256046643849379 3586 4900406 YPR165W RHO1
SGTC_3346 9158254 43.5805 µM -0.655947887576799 0.228225151826029 no 2626 0.255928827454333 3573 17639500
SGTC_1539 benzyladenosine 56 µM -0.656079504673172 0.228179778137904 no 2627 0.255886485373778 3591 92208 A nucleotide analog.
SGTC_2718 lomofungin 53.02 µM -0.656218266327503 0.228131946926988 no 2628 0.255841848801437 3632 5351222 A RNA synthesis inhibitor.
SGTC_992 3909-8734 162 µM -0.657278295589286 0.227766740410893 no 2629 0.255500994853597 3599 4288319
SGTC_1737 st035557 69.7 µM -0.657485471584766 0.22769540157282 no 2630 0.255434404838217 3532 5716916
SGTC_1318 1280-3875 124 µM -0.658995773209222 0.227175725585758 no 2631 0.254949241450739 3592 373245
SGTC_841 0251-0215 91.2 µM -0.659242234558477 0.227090984798355 no 2632 0.254870114960224 3627 3888614
SGTC_1750 st081859 2.357 µM -0.659364470947638 0.227048962881691 no 2633 0.254830875699408 3629 5291695
SGTC_1245 0418-0076 17.2 µM -0.659395556183537 0.227038277228071 no 2634 0.254820897492136 3611 6790114
SGTC_3205 9113483 49.47 µM -0.659538220323332 0.226989239590892 no 2635 0.254775105630902 3608 17018033
SGTC_323 4013-0906 34.3 µM -0.659927183384539 0.226855572502068 no 2636 0.254650279448969 3622 2910086
SGTC_2849 9019321 12.99 µM -0.660013696929145 0.226825848174844 no 2637 0.254622519842415 3577 16489627
SGTC_2966 9084041 48.03 µM -0.661380023025318 0.226356697265366 no 2638 0.254184316967613 3530 17741380
SGTC_2135 5326629 150.42 µM -0.663026283561677 0.225792154892806 no 2639 0.253656860387949 3589 5020077
SGTC_2072 5231554 129 µM -0.663059149111973 0.225780892618268 no 2640 0.253646336227062 3686 789545
SGTC_1102 cgs 12066b 26.1 µM -0.663487959436473 0.22563397822093 no 2641 0.253509044199436 3573 6438352 A 5-HT1B full agonist.
SGTC_480 am 92016 50 µM -0.665788368743668 0.224846760724895 no 2642 0.252773190188127 3557 2129 K+ channel blocker.
SGTC_2079 5212404 121 µM -0.665954928967414 0.224789823071059 no 2643 0.252719954665718 3631 758462
SGTC_1259 0671-0132 43 µM -0.667687375477734 0.224198081179062 no 2644 0.252166585123031 3570 X1259
SGTC_2389 9091542 195.52 µM -0.668202191820864 0.224022408925244 no 2645 0.252002268274777 3619 3626624 YOL127W RPL25
SGTC_1297 1068-0111 14.1 µM -0.669060058935785 0.223729850269732 no 2646 0.251728583532399 3594 767057
SGTC_888 0916-0002 6.97 µM -0.670751212414361 0.223153752365022 no 2647 0.251189516068746 3667 2802138 YIL048W NEO1
SGTC_623 k072-0108 16.9 µM -0.671847849854053 0.222780630464209 no 2648 0.250840281500059 3604 5382803
SGTC_369 0957-0393 4.5 µM -0.673331042978364 0.222276552188018 no 2649 0.250368353848155 3614 6997992
SGTC_1304 1165-0502 251 µM -0.673405930588711 0.222251118141438 no 2650 0.250344538330558 3633 767425
SGTC_1164 k060-0068 93.7 µM -0.673585262023052 0.222190218634359 no 2651 0.250287512804726 3657 5963676
SGTC_2506 ethyl hematommate 54.16 µM -0.674075508180234 0.222023783608006 no 2652 0.250131654795743 3607 3940691 An allergen.
SGTC_595 3909-8003 73.7 µM -0.674423179589033 0.221905794827243 no 2653 0.250021155054274 3670 699517
SGTC_794 k038-0031 316 µM -0.675447059944518 0.221558530000895 no 2654 0.249695887628181 3669 6624242
SGTC_2472 5377652 49.4 µM -0.676837533463384 0.221087427155805 no 2655 0.249254520574939 3637 1610903
SGTC_2264 7948757 110.76 µM -0.678406217170275 0.220556634124766 no 2656 0.248757084104009 3635 2971411
SGTC_1183 1254-0324 198 µM -0.679744545758721 0.220104363756229 no 2657 0.248333112478484 3660 5799357
SGTC_3120 9124077 49.47 µM -0.680905468786284 0.219712476469372 no 2658 0.247965653731233 3698 18774327 YGL155W CDC43
SGTC_2343 7990716 14.84 µM -0.681134807755235 0.219635107013829 no 2659 0.24789309702768 3631 6456862
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.68172971901899 0.219434481577054 no 2660 0.247704935882296 3623 2333 A French combination drug.
SGTC_212 3807-4682 38.772 µM -0.682128785257195 0.219299961137913 no 2661 0.24757876021455 3740 3125501 YBL034C STU1
SGTC_2990 9074105 71.4286 µM -0.682977343531287 0.219014079918239 no 2662 0.247310579551519 3609 6502001
SGTC_2482 5981709 142.65 µM -0.684806516583935 0.218398556874857 no 2663 0.246733011330822 3641 877755
SGTC_230 MPP+ 141.667 µM -0.684890905834768 0.21837018366583 no 2664 0.246706382549866 3624 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_3333 9141820 12.094 µM -0.685047704634516 0.218317470680645 no 2665 0.246656909234291 3642 1939433
SGTC_1677 st019204 53.9 µM -0.685634662316653 0.218120210975462 no 2666 0.246471758936494 3610 3945625
SGTC_2399 5884133 200 µM -0.686249661339237 0.217913637626679 no 2667 0.246277843181474 3665 722445
SGTC_2242 6630449 61.2675 µM -0.686346683905232 0.217881058813581 no 2668 0.246247258402493 3657 691249 YDR170C SEC7
SGTC_2124 5246320 200 µM -0.686638871997045 0.217782963130679 no 2669 0.246155163182405 3650 579342
SGTC_2902 5787006 60.46 µM -0.688253633660181 0.217241302294505 no 2670 0.245646537228392 3628 591003
SGTC_3026 9090633 49.47 µM -0.689948068929192 0.216673753049442 no 2671 0.245113422739501 3653 25236842
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.690353132197495 0.216538204668937 no 2672 0.244986071261086 3648 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1999 st074831 12.5 µM -0.690376805556469 0.216530284250223 no 2673 0.244978629482381 3654 17112523
SGTC_2700 st077718 96.8 µM -0.690867225599177 0.216366241647831 no 2674 0.244824492094891 3652 904970
SGTC_43 0570-0105 72.5 µM -0.691200232024694 0.216254893986231 no 2675 0.24471985904745 3695 1114046 YDL195W SEC31
SGTC_1781 st038725 66.3 µM -0.691322035122813 0.216214174861525 no 2676 0.244681593640313 3679 4270275 YIL048W NEO1
SGTC_2001 4023502 57.655 µM -0.691480260776816 0.216161286201742 no 2677 0.244631890610336 3660 108941 YCR052W RSC6
SGTC_2137 5261020 140 µM -0.6916635301963 0.216100035754163 no 2678 0.244574327441656 3646 763655
SGTC_2067 5224629 34.075 µM -0.691855724083234 0.216035813461019 no 2679 0.244513969021166 3647 2835000
SGTC_2627 acetyl isogambogic acid 100 µM -0.69313561316135 0.215608415879933 no 2680 0.244112225048753 3644 6857789 A caspase activator and apoptosis inducer.
SGTC_1891 st059073 26.2 µM -0.694227044964076 0.215244338091383 no 2681 0.243769917279797 3698 688754
SGTC_1338 1486-1223 76 µM -0.694809299334362 0.215050256797269 no 2682 0.243587409805296 3691 3444526
SGTC_1945 st075991 56.6 µM -0.695329005684 0.214877110323049 no 2683 0.243424570340422 3589 1084980
SGTC_2531 methyl deoxycholate 70.07 µM -0.695989193657136 0.214657277505267 no 2684 0.243217798644118 3655 16667744 Haematoxylin.
SGTC_680 0417-1641 114 µM -0.697926271790078 0.214013014074847 no 2685 0.242611651756518 3656 2835990
SGTC_3228 9131799 49.47 µM -0.69810995424041 0.213951980601487 no 2686 0.242554216675954 3653 17015818
SGTC_3220 9131269 49.47 µM -0.698560997592056 0.213802152218928 no 2687 0.242413212613421 3717 17722206
SGTC_135 0933-0004 26.348 µM -0.699031615953825 0.213645886532735 no 2688 0.242266136413952 3655 21230617 YGL099W LSG1
SGTC_1912 st060209 90.8 µM -0.699818959802101 0.213384603092759 no 2689 0.24202018631881 3670 688787
SGTC_3222 9128301 49.47 µM -0.701037267371811 0.212980669823713 no 2690 0.241639879022348 3715 4911358
SGTC_20 0481-0013 4.944 µM -0.702599234780023 0.212463448428961 no 2691 0.241152769762301 3670 182045
SGTC_148 3253-0744 288.01 µM -0.702761549291316 0.212409742606219 no 2692 0.241102181606167 3650 6893655
SGTC_696 1560-0013 611 µM -0.702766340932302 0.212408157292293 no 2693 0.241100688295135 3722 1650269
SGTC_166 k072-0058 166.424 µM -0.702846896030712 0.212381506681364 no 2694 0.241075584116851 3688 5846229
SGTC_261 5-fluorouridine 15.376 µM -0.704171450602402 0.211943575228161 no 2695 0.240663004020047 3714 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_95 0471-0001 561.058 µM -0.705084498303948 0.211642006204372 no 2696 0.240378826451432 3623 4015405
SGTC_2088 5278280 127.392 µM -0.707069922106135 0.210987111414694 no 2697 0.239761513232217 3735 791502
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.707101628252301 0.210976662745142 no 2698 0.23975166209534 3753 688801
SGTC_1765 st044815 90.4 µM -0.70817396839933 0.210623454791915 no 2699 0.239418614833053 3691 645695
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.708509884234385 0.210512882067323 no 2700 0.239314338131296 3741 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2369 9071472 200 µM -0.709380102340763 0.210226592659025 no 2701 0.239044316026149 3726 17296037
SGTC_631 k072-0230 41.5 µM -0.709751707058013 0.210104409682953 no 2702 0.238929060655743 3709 5773147
SGTC_1274 0865-0114 173 µM -0.710983981643552 0.209699538623199 no 2703 0.238547081059027 3700 870624
SGTC_2452 5863136 48.41 µM -0.71312955624009 0.208995693290622 no 2704 0.23788279582683 3663 2184096
SGTC_1807 st050092 58.9 µM -0.713360184191885 0.208920119819889 no 2705 0.237811452190027 3683 5008496
SGTC_748 act1.228 77.9 µM -0.714227031055537 0.208636210543885 no 2706 0.237543402297957 3645 4421505 YNR035C ARC35
SGTC_3356 9151811 4.48 µM -0.714331230874472 0.20860209838722 no 2707 0.237511192376665 3677 1859254 YPR165W RHO1
SGTC_2181 6316240 54.2555 µM -0.715620448377347 0.208180316085113 no 2708 0.237112871886184 3689 12779990
SGTC_3275 9138069 49.47 µM -0.71614557334888 0.208008659765781 no 2709 0.236950732966958 3772 17617007
SGTC_299 1273-0059 1.44 µM -0.717221408212192 0.207657244816373 no 2710 0.236618745875654 3656 2848077
SGTC_3059 1327-0034 3 µM -0.71776164975822 0.20748091055868 no 2711 0.236452131708873 3666 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_960 1222-0186 7.7 µM -0.718143350848977 0.207356377107228 no 2712 0.236334451437197 3718 3126296
SGTC_779 1360-0071 233 µM -0.718374352997815 0.207281032026012 no 2713 0.236263248035826 3752 7566
SGTC_2263 7948595 193.29 µM -0.719550369391407 0.206897706363659 no 2714 0.235900939532133 3696 2971371
SGTC_2177 5811945 192 µM -0.720048927854489 0.206735326628934 no 2715 0.235747435542889 3735 5343475
SGTC_2907 7721985 69.9 µM -0.720242609783023 0.2066722650747 no 2716 0.235687816575288 3679 3267881
SGTC_583 1488-1091 88.9 µM -0.720554955467082 0.206570591387503 no 2717 0.235591688175267 3792 4303273
SGTC_2085 5307070 144.047 µM -0.720944339857448 0.206443881824314 no 2718 0.235471880417183 3679 2840351
SGTC_3050 9093513 49.47 µM -0.720998847065573 0.206426148310258 no 2719 0.23545511204675 3712 25236664
SGTC_1039 k821-0043 94 µM -0.721655720403806 0.206212510450695 no 2720 0.235253086098696 3667 15992768
SGTC_2836 9010338 19.48 µM -0.721753353403479 0.206180768024682 no 2721 0.23522306656494 3658 2994051
SGTC_2406 ethylparaben 405.7 µM -0.724387609710891 0.205325412952925 no 2722 0.234413902211237 3718 8434 A possible steroid mimic.
SGTC_766 1391-0721 126 µM -0.724965597457602 0.205138020055854 no 2723 0.234236568019856 3703 1020919 YIL115C NUP159
SGTC_231 b-estradiol 524 µM -0.728442442052479 0.204012917518497 no 2724 0.233171395240869 3664 450 A steroid.
SGTC_948 3448-0295 75.3 µM -0.729258118895475 0.203749498928245 no 2725 0.23292189288964 3735 678569
SGTC_1019 4262-0212 3.4 µM -0.729573126854194 0.203647823045906 no 2726 0.232825576760457 3765 4677213
SGTC_3022 9087993 49.47 µM -0.730736429847044 0.203272603174056 no 2727 0.232470079662535 3749 17173644
SGTC_2434 5670830 169.91 µM -0.730797340881216 0.203252967877703 no 2728 0.232451474005247 3748 1549830
SGTC_2835 9006588 71.43 µM -0.734934838314347 0.201921854789279 no 2729 0.231189589927039 3753 2345538
SGTC_1645 Cervolide 78 µM -0.735153235222209 0.201851737578389 no 2730 0.231123088016078 3696 23173 A fragrance.
SGTC_839 0122-0028 230 µM -0.7352870503031 0.201808782908691 no 2731 0.231082346566522 3758 759448
SGTC_2403 6032726 181.2 µM -0.735844491949534 0.201629902921579 no 2732 0.230912670557933 3756 2881040
SGTC_2893 9048488 25.97 µM -0.736335861574838 0.201472303874162 no 2733 0.230763163480316 3725 6467338
SGTC_1901 st060216 58.6 µM -0.736495227836185 0.201421205519863 no 2734 0.230714685357379 3738 688792
SGTC_1174 0739-0097 51.1 µM -0.737915147726785 0.200966272907834 no 2735 0.230283006719365 3749 728447
SGTC_2339 9000433 200 µM -0.737946654509005 0.200956185346408 no 2736 0.23027343327273 3754 2988954
SGTC_390 dec-rvkr-cmk 16.7 µM -0.738391316576483 0.200813849798936 no 2737 0.230138344879048 3790 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.738397856225968 0.200811756920165 no 2738 0.230136358463559 3706 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1148 3909-7663 27.7 µM -0.740392705658486 0.200173958037098 no 2739 0.229530871789283 3795 4084526
SGTC_1483 3453-0561 55.9 µM -0.742165859477635 0.199608063597312 no 2740 0.228993425418823 3737 4546991
SGTC_2021 4019055 173 µM -0.742185111441042 0.199601924703491 no 2741 0.228987593988598 3730 44827708 YER133W GLC7
SGTC_2148 5546263 113.568 µM -0.742667726207954 0.199448069951235 no 2742 0.228841436939821 3743 792097
SGTC_168 3970-0862 530.542 µM -0.744260788805067 0.19894071794649 no 2743 0.228359359158699 3751 3135186
SGTC_3191 9110352 49.47 µM -0.74484244574304 0.198755668255571 no 2744 0.228183485880513 3713 17122424
SGTC_1074 carmofur 3.8 µM -0.744920815808891 0.19873074335644 no 2745 0.228159795260587 3776 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_776 4476-4378 112 µM -0.746622096585816 0.198190130855976 no 2746 0.227645853205706 3806 2892008
SGTC_860 0443-0016 25.1 µM -0.747237766485382 0.197994709678341 no 2747 0.227460025442382 3775 5337942
SGTC_196 k015-0023 18.111 µM -0.749387398545413 0.197313303146811 no 2748 0.226811871979918 3736 5211998
SGTC_3159 9100096 49.47 µM -0.750584329043833 0.19693450667725 no 2749 0.226451427591139 3721 25236875
SGTC_2558 carylophyllene oxide 100 µM -0.751896565324174 0.196519725293835 no 2750 0.22605663190697 3840 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_290 2043-6722 48.1 µM -0.75509367883387 0.195511376224552 no 2751 0.225096387841801 3763 773758 YLR208W SEC13
SGTC_1800 st050079 29.0735 µM -0.757317048812537 0.194811995468091 no 2752 0.224429969619589 3700 3645560
SGTC_1816 st051957 91.6 µM -0.758719787365021 0.194371535502428 no 2753 0.224010098760907 3760 674121
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.761399095409408 0.193531919417931 no 2754 0.223209363796816 3718 140250 A respiratory chain inhibitor.
SGTC_2189 6047310 154.431 µM -0.762373999327959 0.193226963030993 no 2755 0.222918409902537 3720 711535
SGTC_3121 9125696 49.47 µM -0.762448656106895 0.193203621993632 no 2756 0.222896137969449 3826 1235365
SGTC_1833 st055984 71 µM -0.762530504842052 0.193178034407892 no 2757 0.222871721957682 3816 676288
SGTC_661 1304-0007 33.6 µM -0.762696566836508 0.193126126394305 no 2758 0.222822189263355 3779 3117130
SGTC_1075 aripiprazole 15.2 µM -0.762763353621465 0.193105252439333 no 2759 0.222802269981469 3799 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1077 5-fluorocytosine 377 nM -0.76312772934998 0.19299139245423 no 2760 0.22269361211877 3807 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2762 leflunomide 42.06 µM -0.763984572746085 0.192723807966801 no 2761 0.222438218074772 3753 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1249 0481-0015 10.2 µM -0.766725090336346 0.191869492155072 no 2762 0.22162249134313 3732 4227577
SGTC_86 0417-1630 471.922 µM -0.767791803652577 0.191537587844395 no 2763 0.221305442380504 3808 3634867
SGTC_2453 5731132 22.18 µM -0.768704321114173 0.191253940385109 no 2764 0.221034429559113 3804 1362040
SGTC_2461 5755302 26.15 µM -0.768813775794117 0.191219934732229 no 2765 0.221001934865222 3769 2788904
SGTC_764 1951-2361 146 µM -0.769862903088585 0.190894177314627 no 2766 0.220690610713695 3762 5438930
SGTC_710 3448-4187 58 µM -0.772109809784134 0.190197651780483 no 2767 0.220024696304283 3791 3946412
SGTC_552 k242-0005 476 µM -0.77225085870383 0.190153979740942 no 2768 0.219982932208805 3839 4088318
SGTC_2867 9039098 71.43 µM -0.772299962524767 0.190138777497274 no 2769 0.21996839380534 3753 6463460
SGTC_3307 9126885 69.2785 µM -0.772674026837305 0.190022993981977 no 2770 0.219857660890717 3785 24824909
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.772987314838826 0.189926055812563 no 2771 0.219764943992765 3826 521171
SGTC_1863 st057641 20.1 µM -0.773386550102801 0.18980256774284 no 2772 0.219646823724854 3812 3921635
SGTC_7 0192-1582 4.227 µM -0.773463403277322 0.18977880183823 no 2773 0.219624089644255 3833 252616
SGTC_3097 9117246 49.47 µM -0.777736580771536 0.188460254959062 no 2774 0.218362161046121 3823 16423892
SGTC_2358 9037157 4 µM -0.778579080201617 0.188200958663993 no 2775 0.218113853114348 3820 2388925
SGTC_474 dl-dihydrosphingosine 5 µM -0.778884773165767 0.188106929907023 no 2776 0.218023797179865 3801 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_1930 st074634 34.3 µM -0.780845010637201 0.187504665567833 no 2777 0.21744682867367 3737 684253 YOR116C RPO31
SGTC_3010 9080089 71.4286 µM -0.780895964559989 0.187489026366319 no 2778 0.217431842862114 3800 17027233
SGTC_1320 1313-0481 95.3 µM -0.78261806727527 0.186960938409941 no 2779 0.216925714288626 3791 6813365 YLR208W SEC13
SGTC_2868 9035608 32.47 µM -0.784159943541247 0.18648889912677 no 2780 0.216473132918716 3780 6462614
SGTC_18 0111-0177 500 nM -0.784464016988554 0.186395895462759 no 2781 0.216383943884314 3874 721752
SGTC_572 0960-0087 17.7 µM -0.784534192370163 0.186374435757338 no 2782 0.216363363475305 3823 6796365
SGTC_2026 5148700 152 µM -0.78472756530015 0.186315310032249 no 2783 0.216306658652672 3803 79838
SGTC_2739 tacrine 100.86 µM -0.786147179252672 0.185881604645343 no 2784 0.215890633487783 3825 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.787359501501536 0.185511724881134 no 2785 0.215535723554808 3863 5282309
SGTC_2924 9010168 62.78 µM -0.787636561193388 0.185427258082602 no 2786 0.215454661265097 3905 2993929
SGTC_741 4582-0002 126 µM -0.78793617446333 0.185335942278886 no 2787 0.215367020142172 3771 2912688
SGTC_1550 gossypolone 36.6 µM -0.790945138849174 0.184420422250357 no 2788 0.214488003096033 3819 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2580 diallyl disulphide 81.36 µM -0.791890152798499 0.184133469902876 no 2789 0.214212364603803 3845 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1054 3429-0080 167 µM -0.792030027721282 0.184091020675951 no 2790 0.214171583872869 3806 1162877
SGTC_1430 4049-0248 69.1 µM -0.792436565370993 0.183967679260023 no 2791 0.214053082895301 3824 22774488
SGTC_3229 9132204 49.47 µM -0.795126896294572 0.183152744390909 no 2792 0.213269845276622 3835 17682924
SGTC_2054 5233173 129 µM -0.795849139332934 0.182934351922214 no 2793 0.213059863118444 3857 6889
SGTC_791 1348-1292 225 µM -0.796821083407479 0.182640711259566 no 2794 0.212777474298917 3805 5437054
SGTC_1629 st005085 44.9 µM -0.797794636155334 0.182346879822613 no 2795 0.212494837253962 3820 24207091
SGTC_557 1315-0110 16.2 µM -0.797930196326216 0.182305989362217 no 2796 0.212455499494578 3829 6833801
SGTC_3272 9137413 49.47 µM -0.79929164842951 0.181895637839132 no 2797 0.212060660186049 3780 17614870
SGTC_122 0236-0016 402.397 µM -0.801459061876137 0.181243556666227 no 2798 0.211432967422094 3851 6808838
SGTC_385 1494-0393 12.4 µM -0.80517564387837 0.180128810100927 no 2799 0.210359164685781 3841 3090647
SGTC_1887 st057648 70.8 µM -0.80676241529057 0.179654189918659 no 2800 0.209901688393062 3872 688672
SGTC_2556 citropten 84.59 µM -0.807427250608615 0.179455564429718 no 2801 0.209710186097917 3885 2775 A potential DNA crosslinker.
SGTC_2113 5491891 107.031 µM -0.807799262708979 0.17934448275026 no 2802 0.209603074821538 3858 789979
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.811229767447975 0.178322182927568 no 2803 0.208616866998488 3887 279621
SGTC_1527 coumarin 137 µM -0.81203215757342 0.178083599376 no 2804 0.208386589757577 3966 323 A hepatotoxic, DNA x-linker.
SGTC_2235 salicylic acid 500 µM -0.812320552202439 0.177997896989993 no 2805 0.208303860275584 3844 338 A COX inhibitor and kinase inhibitor.
SGTC_1374 2889-5571 141 µM -0.815271013779987 0.17712260128018 no 2806 0.207458598426316 3886 2853281
SGTC_978 1416-0512 87.4 µM -0.817611674240157 0.176430149156682 no 2807 0.206789479659637 3924 6814003
SGTC_1920 st075728 45.7 µM -0.819101746620183 0.175990225146804 no 2808 0.20636418274042 3814 3400306
SGTC_682 0kpi-0099 17 µM -0.820796243971339 0.175490792202908 no 2809 0.205881169204474 3910 1714895 YML126C ERG13
SGTC_3031 9088762 49.47 µM -0.821286047564796 0.175346595947364 no 2810 0.205741676589154 3834 205253
SGTC_1910 st062352 60.4 µM -0.821365411545368 0.175323238577076 no 2811 0.205719079567557 3808 2245730
SGTC_2400 5203494 178.7 µM -0.821687928485526 0.175228339902407 no 2812 0.205627265631676 3795 6777674
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.821742356981443 0.175212327857276 no 2813 0.205611773358148 3865 442882
SGTC_2671 danthron 100 µM -0.822384403076549 0.175023517587587 no 2814 0.205429076647121 3844 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_2951 9072950 58.06 µM -0.824276865925415 0.174467741259436 no 2815 0.204891130150653 3867 16488155
SGTC_2652 actinonin 100 µM -0.824614019577867 0.174368844131514 no 2816 0.204795379723452 3834 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_580 1123-0028 41 µM -0.824754400454076 0.174327676776595 no 2817 0.204755519906744 3932 1677248 YPR107C YTH1
SGTC_282 k297-0036 65.7 µM -0.825010132572106 0.17425269799808 no 2818 0.204682919060952 3846 5061378
SGTC_2068 5226020 147 µM -0.825463937520493 0.174119696176625 no 2819 0.204554124207054 3918 1810509
SGTC_1029 k015-0030 64.7 µM -0.82666213948186 0.173768835590363 no 2820 0.204214293109396 3955 2208316
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.827152938441775 0.173625248497304 no 2821 0.204075191034096 3812 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.830410628687691 0.172674099957117 no 2822 0.203153329146617 3856 6312947
SGTC_3138 9097216 49.47 µM -0.832994395485085 0.171922083746418 no 2823 0.202423945061579 3869 25237486
SGTC_1663 st014140 55.4 µM -0.834434076083755 0.171503967257993 no 2824 0.202018210852218 3945 4207120
SGTC_49 0717-0965 32.132 µM -0.836473913360837 0.170912665035753 no 2825 0.201444173169611 3920 5889349 YGL099W LSG1
SGTC_2320 7373003 200 µM -0.838236662968363 0.170402736119568 no 2826 0.20094889991749 3966 5415828
SGTC_3249 9135183 49.47 µM -0.838855047982863 0.170224080569323 no 2827 0.200775327804393 3900 4902779
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.839914135439326 0.16991838203509 no 2828 0.200478265726693 3909 368090
SGTC_2388 9080168 200 µM -0.840649601546483 0.169706301850094 no 2829 0.200272131177185 3872 15943073
SGTC_2084 5306078 60.6385 µM -0.840815761301189 0.16965841127832 no 2830 0.20022557799095 3843 679340
SGTC_625 k213-0058 121 µM -0.841061611078899 0.16958756834853 no 2831 0.20015670988146 3952 3655420
SGTC_2796 7949634 45.45 µM -0.841513339904127 0.169457449746679 no 2832 0.200030207490139 3853 2971588
SGTC_1410 3909-8106 77.9 µM -0.842062289068458 0.169299413487141 no 2833 0.199876544175386 3923 1039210
SGTC_1835 st008666 49.2 µM -0.843131427366526 0.168991892314765 no 2834 0.199577471981808 3816 690455
SGTC_2731 amoxapine 43.43 µM -0.84320091659213 0.168971917234221 no 2835 0.19955804294707 3973 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2885 9057732 51.95 µM -0.845678121603616 0.16826082113565 no 2836 0.198866165711363 3928 6471414
SGTC_2854 9024559 71.43 µM -0.850879946547194 0.166773882232198 no 2837 0.197418022769987 3953 3163529
SGTC_3000 9075062 71.4286 µM -0.85605119060661 0.165304114688707 no 2838 0.195984732462112 3877 17057871
SGTC_1045 1348-1485 165 µM -0.857576578268344 0.164872175770974 no 2839 0.195563156370934 3927 6810614
SGTC_556 4058-0063 51.5 µM -0.859289476572301 0.164388012188091 no 2840 0.195090414301175 3964 6615692
SGTC_1126 isoteolin 1.0172 µM -0.861158517463621 0.163860766407787 no 2841 0.194575371785298 3869 133323
SGTC_1818 st052136 56.3 µM -0.861724369347137 0.16370135947436 no 2842 0.194419606056941 3743 674169
SGTC_3072 9116419 49.47 µM -0.862611175656647 0.163451738600619 no 2843 0.194175641875523 3955 17170162
SGTC_3057 9095946 49.47 µM -0.863345637001317 0.163245187503098 no 2844 0.193973729672927 3930 24540043
SGTC_1856 st057054 55.7 µM -0.866333953848396 0.162406538771463 no 2845 0.193153525732135 3933 1266018
SGTC_2617 dihydrotanshinone i 20.83 µM -0.867615416033355 0.162047766601624 no 2846 0.192802452115813 3926 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_3115 9123671 49.47 µM -0.868440012025219 0.161817176851922 no 2847 0.192576749344339 4022 3286988
SGTC_3252 9135871 49.47 µM -0.869484051169915 0.161525528970346 no 2848 0.192291213887875 3940 17682838
SGTC_447 ml7 120 µM -0.872158660939465 0.160779952687909 no 2849 0.191560914006766 3956 4216 Selective myosin light chain kinase inhibitor.
SGTC_1062 mesoridazine 14.2 µM -0.872162148786099 0.160778981882491 no 2850 0.191559962763914 3936 4078 A neuroleptic.
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -0.873977995303809 0.160274079817521 no 2851 0.191065118646978 3894 4330530
SGTC_2943 9068529 45.32 µM -0.878391789411121 0.159051135642206 no 2852 0.189865569282333 3933 3270634
SGTC_1278 0874-0585 172 µM -0.879696436020756 0.158690826715559 no 2853 0.18951189030412 4000 766306
SGTC_3268 9137683 49.47 µM -0.879722898529595 0.158683524011413 no 2854 0.189504720732635 3963 1953228
SGTC_3316 9136639 10.545 µM -0.880960505172602 0.158342235050529 no 2855 0.189169598491785 3963 4903665
SGTC_1051 3253-3903 78 µM -0.881824701417442 0.158104205478367 no 2856 0.188935805779572 3941 5509239
SGTC_2470 5664817 21.68 µM -0.882923672247231 0.15780185027662 no 2857 0.188638756287644 3959 2859561
SGTC_2484 5809818 12.04 µM -0.883264613112779 0.157708125890559 no 2858 0.188546659240555 3924 2870548
SGTC_2165 5727197 32.143 µM -0.883791615323181 0.157563325342123 no 2859 0.188404356716458 4123 1361712
SGTC_2826 7992541 19.48 µM -0.88381358192127 0.157557291637542 no 2860 0.188398426676323 3972 2985066
SGTC_3200 9114385 49.47 µM -0.884383393840712 0.157400830838993 no 2861 0.188244642104901 4006 17018030 YLR208W SEC13
SGTC_59 0330-0160 1.33 µM -0.88737599222086 0.156580790660587 no 2862 0.187438252276467 3912 4293482
SGTC_616 4092-0450 108 µM -0.887804868779168 0.156463499550242 no 2863 0.187322861755081 3970 787165
SGTC_1692 fluoroquinolonic acid 71 µM -0.8879782834428 0.156416089750557 no 2864 0.18727621649262 4009 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_3166 9102297 49.47 µM -0.888827017408118 0.15618419101625 no 2865 0.18704802672146 3986 25237072
SGTC_1623 st003709 20.3 µM -0.889766439778079 0.155927777831711 no 2866 0.186795655195865 3921 16192618
SGTC_3078 9116413 49.47 µM -0.892182685500288 0.155269544525042 no 2867 0.186147510581932 3864 17177322
SGTC_341 1486-1430 230 µM -0.892250335933383 0.155251141635726 no 2868 0.186129383807922 3935 2054753 YPL210C SRP72
SGTC_448 monastrol 171 µM -0.892843528112355 0.155089837735653 no 2869 0.1859704862227 3883 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_3035 9091303 49.47 µM -0.894443682861623 0.15465526737584 no 2870 0.185542274556582 4014 25237002
SGTC_655 k060-0012 42 µM -0.899529439319861 0.153279424354794 no 2871 0.184185361115397 3963 5994525
SGTC_1221 2958-7315 257 µM -0.902002124889141 0.15261343096784 no 2872 0.18352786948429 3990 4562705
SGTC_1342 1486-1464 234 µM -0.902097685049817 0.152587731372528 no 2873 0.183502489256052 3998 3253938
SGTC_2697 mebhydrolin 72.4 µM -0.902639440164571 0.152442088044829 no 2874 0.183358643579445 4058 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1402 3909-7673 35.9 µM -0.902713920360568 0.152422072296052 no 2875 0.183338873253247 3968 5328014
SGTC_1271 0832-2808 169 µM -0.903985779884709 0.152080542984777 no 2876 0.183001470854583 4017 3663794
SGTC_2047 4141938 200 µM -0.905025956038755 0.151801605111446 no 2877 0.182725818253081 3969 3807862
SGTC_864 0469-0573 172 µM -0.905576304157601 0.151654159120818 no 2878 0.182580077785903 3943 689425
SGTC_1193 1488-0126 41.5 µM -0.906577386450599 0.151386199246462 no 2879 0.182315162308677 3977 1384710
SGTC_1447 4239-0816 81.9 µM -0.907636537630247 0.15110303904513 no 2880 0.182035141748235 3988 1341554
SGTC_1321 1326-2144 215 µM -0.908621083708876 0.150840140486785 no 2881 0.181775086736455 3991 3513030
SGTC_412 gemfibrozil 100 µM -0.911796536214921 0.149994290738632 no 2882 0.180937917052546 3922 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2223 6903751 107.57 µM -0.913068202796096 0.149656443713622 no 2883 0.180603336177629 3949 5598863
SGTC_2601 securinine 100 µM -0.91452892788166 0.149268996048736 no 2884 0.180219492350956 3956 442872 A GABA receptor antagonist.
SGTC_3169 9102970 49.47 µM -0.915038467575522 0.149134001719479 no 2885 0.180085717975533 4038 17027839
SGTC_2728 chlorpromazine 9.18 µM -0.917820589323569 0.148398361765134 no 2886 0.179356400589434 3993 2726 A thorazine and dopamine antagonist.
SGTC_17 0960-0276 49.807 µM -0.918632271874022 0.148184197298609 no 2887 0.179143973060568 3990 6821114
SGTC_596 1155-0152 116 µM -0.919373816056122 0.147988719871424 no 2888 0.17895004002725 3989 280313
SGTC_2758 dehydroepiandrosterone 69.35 µM -0.92006633667083 0.147806321408438 no 2889 0.178769047279925 4025 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_1516 st013856 110 µM -0.921610627580105 0.147400123057591 no 2890 0.178365856510911 4050 5281404 A mutagen and neurotoxin.
SGTC_1480 1070-0044 41.2 µM -0.924090467989223 0.146749411413309 no 2891 0.177719607853744 4003 3124987
SGTC_2956 9076196 2.52 µM -0.924477197785618 0.146648107263088 no 2892 0.17761895903531 4012 16423868
SGTC_1223 0764-0573 147 µM -0.924850319795895 0.146550412173114 no 2893 0.177521885828425 3987 1609797
SGTC_2228 7354201 200 µM -0.925630027060457 0.146346401308634 no 2894 0.177319141580708 4012 753451
SGTC_1441 4106-0040 13 µM -0.925829520634115 0.146294234348633 no 2895 0.177267291541906 3982 2904180
SGTC_2889 9059656 51.95 µM -0.925957926998738 0.146260663082807 no 2896 0.177233922725226 4094 3949838
SGTC_2279 7948423 32.93 µM -0.927147537403492 0.145949890792909 no 2897 0.176924968657654 3924 1247112
SGTC_1392 3455-1037 33.9 µM -0.927300228722374 0.145910034063623 no 2898 0.176885337811362 4023 981132
SGTC_677 0929-0063 136 µM -0.929059481572653 0.145451347205091 no 2899 0.176429130649719 3969 1539583
SGTC_1236 0330-0013 258 µM -0.930006422505571 0.145204854913741 no 2900 0.17618387958847 4016 4617066
SGTC_1098 clofazimine 15.1 µM -0.930831515395229 0.144990309413706 no 2901 0.175970362320971 4076 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_651 3253-0966 34.4 µM -0.935437983766709 0.143796431071025 no 2902 0.174781314774473 4030 781462
SGTC_268 camptothecin 39.6153 µM -0.936624250462264 0.143490058209998 no 2903 0.17447593665111 3978 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1574 spiramycin 23.7 µM -0.937109911738487 0.14336475543435 no 2904 0.174351011730694 3983 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2534 helenine 20.12 µM -0.938813324295297 0.142925851564412 no 2905 0.173913298330776 4009 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2822 7994718 71.43 µM -0.939136064405137 0.142842796287428 no 2906 0.173830444986058 3999 1018011
SGTC_2268 7933382 153.85 µM -0.94251667297565 0.141974777015328 no 2907 0.172964089508234 4031 935025 YOR257W CDC31
SGTC_402 epigallocatechin gallate 10 µM -0.94352517365855 0.141716523141346 no 2908 0.172706172653184 3961 65064 An antioxidant.
SGTC_2462 5162487 171.77 µM -0.943767599139625 0.14165449100715 no 2909 0.172644210635219 3909 2259986
SGTC_2008 4012253 172 µM -0.944908535025711 0.141362793922869 no 2910 0.172352786875828 4026 603940
SGTC_428 3448-4153 16.5 µM -0.945808892806621 0.141132891778398 no 2911 0.172123034492928 3998 3834874
SGTC_3309 9129340 25.759 µM -0.945993646583479 0.141085747134054 no 2912 0.172075913393889 4037 17158987
SGTC_1777 st045864 34.765 µM -0.94608553287882 0.141062303976207 no 2913 0.172052481035446 4000 4691462
SGTC_1328 1441-0025 69.2 µM -0.947140213868773 0.140793410015563 no 2914 0.171783667727285 4001 4562601
SGTC_158 k038-0087 26.446 µM -0.947817436743843 0.140620933560265 no 2915 0.171611201086463 3942 X158
SGTC_1768 st044301 37.178 µM -0.949770955456575 0.14012421130693 no 2916 0.171114323479964 4036 3931349
SGTC_2896 9052656 71.43 µM -0.949993528557397 0.140067693260142 no 2917 0.171057770442138 3901 6469436
SGTC_3134 9127454 49.47 µM -0.950859359717607 0.139847979854067 no 2918 0.170837887312703 4073 24262820
SGTC_591 4299-0174 154 µM -0.952410501861914 0.139454947899866 no 2919 0.170444417739079 4024 5509088
SGTC_379 3970-0972 5.9 µM -0.954604792463016 0.138900237851042 no 2920 0.169888796344843 4020 2898042 YBL034C STU1
SGTC_2982 9019404 25.97 µM -0.956577115955241 0.138402924200584 no 2921 0.169390371915775 3980 22333232
SGTC_2283 7944793 200 µM -0.9573054687205 0.138219580093679 no 2922 0.169206547940256 4079 2970533
SGTC_2195 6536160 144.242 µM -0.960725418845183 0.137360910166017 no 2923 0.168345123484018 3988 3834386
SGTC_2626 ethyl orsellinate 100 µM -0.961649376962023 0.137129552118608 no 2924 0.168112879703132 4038 75653 A natural product.
SGTC_633 0437-0093 97.7 µM -0.962327314506962 0.136959966756208 no 2925 0.167942606224249 3993 2831118
SGTC_951 1171-0579 82.7 µM -0.963373982901314 0.13669842530984 no 2926 0.167679938922635 3994 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3044 9093193 49.47 µM -0.963394788345329 0.136693229910203 no 2927 0.167674720363096 4085 25236277
SGTC_521 r062-0005 13.8 µM -0.964166557338133 0.136500604180373 no 2928 0.167481214048504 3961 2832033
SGTC_176 1486-1328 72.834 µM -0.970217418390727 0.134996804882087 no 2929 0.165969065102299 4123 22310231
SGTC_2012 4023501 200 µM -0.972662465093649 0.134392381498896 no 2930 0.165360543035704 4079 3477460
SGTC_1581 himbacine 57.9 µM -0.975289989627216 0.133744923246875 no 2931 0.164708217290598 4057 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1388 3346-4487 254 µM -0.976061591742246 0.133555197841425 no 2932 0.164516971614567 4120 3345614
SGTC_2992 9074591 71.4286 µM -0.977098612455579 0.133300501633154 no 2933 0.164260167318957 4016 17741321
SGTC_2218 6965428 192.983 µM -0.979230590909736 0.132777929939467 no 2934 0.163733028385879 3951 675684
SGTC_1740 st038286 13.222 µM -0.985041088356755 0.131360881051319 no 2935 0.162301944385188 4131 716786
SGTC_2784 7567673 72.73 µM -0.987385403976951 0.130792122611411 no 2936 0.161726868521494 4054 3471247
SGTC_2334 9017922 200 µM -0.987826160322841 0.130685380335102 no 2937 0.161618896612084 4152 3163164
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.988707518902671 0.130472113765816 no 2938 0.161403131504605 4131 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1868 st057644 42.7 µM -0.989247538371494 0.130341561644901 no 2939 0.161271022366772 4079 688665
SGTC_316 k060-0003 58.6 µM -0.990331214290845 0.130079850840916 no 2940 0.161006127205209 4101 6152314
SGTC_3085 9117376 49.47 µM -0.991152061624484 0.129881856113388 no 2941 0.160805667328586 4166 16480349
SGTC_1893 st059353 36.1 µM -0.991970858860011 0.129684563852885 no 2942 0.160605870522778 4091 3112488
SGTC_317 4495-0002 170 µM -0.993014940932503 0.12943328958604 no 2943 0.16035133668964 4114 15991618
SGTC_14 0354-0009 295 µM -0.993553921365192 0.129303707839295 no 2944 0.160220043389445 4155 1713507
SGTC_674 0498-0004 451 µM -0.993589511997851 0.129295154300479 no 2945 0.160211376139361 4073 4231473
SGTC_2059 5238311 157 µM -0.993602600950448 0.129292008715664 no 2946 0.160208188714089 4071 703021
SGTC_902 1120-0002 2.07 µM -0.994077657388818 0.12917787731662 no 2947 0.160092530896876 4056 3280475
SGTC_125 0133-0007 11.75 µM -0.995452557146204 0.128847953937605 no 2948 0.159758103849789 4159 26541
SGTC_966 1300-0360 30.2 µM -0.997734813546437 0.128301590932006 no 2949 0.159203983522588 4065 70588
SGTC_1651 st011928 86.1 µM -0.997975505623669 0.128244064128588 no 2950 0.159145618170025 4108 720198
SGTC_2856 9022925 19.48 µM -0.999623813721729 0.127850590261604 no 2951 0.158746297119143 4150 4944862
SGTC_2297 7971671 152.32 µM -1.0005506327245 0.127629714640168 no 2952 0.158522053614489 4108 909016
SGTC_3172 9105863 49.47 µM -1.00422833434938 0.126755875683194 no 2953 0.157634283873459 4122 2348785
SGTC_2325 6158266 200 µM -1.0053176263105 0.126497856418227 no 2954 0.157371965145463 4123 3623240
SGTC_2715 st079500 56.4 µM -1.00679620516018 0.12614821295748 no 2955 0.157016359322769 4058 28246688
SGTC_547 1120-0019 610 nM -1.00698358948845 0.126103949833033 no 2956 0.156971330194588 4052 3676939
SGTC_2878 9043973 25.97 µM -1.0088794884436 0.125656717599742 no 2957 0.156516216683272 4152 6465167
SGTC_2505 galangin 7.89 µM -1.00954661641236 0.125499609274454 no 2958 0.156356278424309 3990 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_630 4356-0227 183 µM -1.00975638114279 0.125450238119433 no 2959 0.156306011365721 4067 779312
SGTC_1353 1498-1206 8.11 µM -1.01001430589599 0.12538955039226 no 2960 0.156244218052924 4141 6756808
SGTC_2203 7227154 166.4 µM -1.01015218588813 0.125357116688742 no 2961 0.1562111915265 4081 896304
SGTC_1530 rhein 70.4 µM -1.01201843938542 0.12491869130494 no 2962 0.155764618500892 4155 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_460 trequinsin 123 µM -1.01256547650781 0.124790383110615 no 2963 0.155633878499533 4149 5537 A vasodilator.
SGTC_2939 9044578 71.43 µM -1.01353493033257 0.12456322286639 no 2964 0.15540236019118 4044 2653634
SGTC_1159 4092-0538 61.2 µM -1.01479469369517 0.124268470048414 no 2965 0.155101851850208 4138 717301
SGTC_1339 1486-1321 22.7 µM -1.01509280142794 0.124198791804912 no 2966 0.155030796368663 4125 3469382
SGTC_1943 st076331 65.2 µM -1.01691490488499 0.123773496301234 no 2967 0.154596956103043 4120 24208415
SGTC_1631 benzylvanillin 81.9 µM -1.0204147939614 0.122959452766438 no 2968 0.153765890278617 4198 75506
SGTC_1474 0330-0125 5.35 µM -1.02053905022935 0.122930621007645 no 2969 0.153736439480735 4119 X1474
SGTC_866 0495-0101 262 µM -1.02081129338755 0.122867467734339 no 2970 0.153671926387784 4087 635694
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.02322120580447 0.122309423200355 no 2971 0.153101634362527 4114 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1104 tacrolimus 29.8 µM -1.02335300073332 0.122278955872552 no 2972 0.153070486352357 4155 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_1952 st077036 64.1 µM -1.02709988968533 0.121415007127222 no 2973 0.152186715310604 4138 2937007
SGTC_422 cantharidin 155 µM -1.0289597220905 0.120987768880992 no 2974 0.151749301145723 4042 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1476 4112-3294 3.34 µM -1.02897460013346 0.120984355386766 no 2975 0.151745805349188 4137 704369
SGTC_1633 st005664 67.9 µM -1.03084365817817 0.120556073119723 no 2976 0.15130707063619 4115 2063822
SGTC_3206 9114350 49.47 µM -1.03085712073962 0.120552992140346 no 2977 0.151303913555364 4026 17087243
SGTC_2998 9066762 71.4286 µM -1.03347685655469 0.119954506362749 no 2978 0.150690397829415 4191 4945196
SGTC_3112 9123419 49.47 µM -1.03501057074622 0.119605098746628 no 2979 0.150331987288122 4169 17015854
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -1.03961947537545 0.11855942961895 no 2980 0.149258362552583 4119 5106787 A p450 inhibitor.
SGTC_2933 9026794 32.47 µM -1.04459946642025 0.11743684821249 no 2981 0.148104063159571 4091 17586027
SGTC_2737 bleomycin 30.5 nM -1.04572899573821 0.117183282151366 no 2982 0.147843085807758 4175 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_711 k292-0785 179 µM -1.04672985547998 0.116958925202764 no 2983 0.147612094953767 4071 4146315
SGTC_1305 1181-0477 144 µM -1.04782817015172 0.116713072862916 no 2984 0.147358890577587 4208 6252086
SGTC_378 3970-0959 8.33 µM -1.04794463493259 0.116687024297231 no 2985 0.147332057981302 4173 6615653
SGTC_688 0527-0193 473 µM -1.05066987513555 0.116078672252197 no 2986 0.146705118201268 4206 4007154
SGTC_2817 7995342 71.43 µM -1.05285374734051 0.115592796587824 no 2987 0.146204013604612 4140 18879975
SGTC_1135 dihydrocapsaicin 536.708 nM -1.05491206044579 0.115136180003996 no 2988 0.145732772932728 4064 107982 A Capsaicinoid.
SGTC_1764 st044502 93.5 µM -1.05591069898846 0.114915104480283 no 2989 0.145504507809326 4192 8407
SGTC_2614 arthonioic acid 13.39 µM -1.06209952410876 0.113551773897732 no 2990 0.144095253066654 4017 6710684
SGTC_2996 9066192 71.4286 µM -1.06241970923296 0.113481555707539 no 2991 0.144022595098522 4201 6472854
SGTC_856 0433-0016 11.3 µM -1.06490875380569 0.112936751659326 no 2992 0.1434586116457 4202 3911780
SGTC_251 melphalan 456.522 µM -1.06774359773151 0.112318535781965 no 2993 0.142818093201078 4194 460612 A DNA alkylator.
SGTC_2280 7785178 200 µM -1.06817334730457 0.112225028525727 no 2994 0.142721162483728 4150 2954328
SGTC_2635 hydroquinidine 100 µM -1.07259847797554 0.111265419244391 no 2995 0.14172565397379 4096 442912 An experimental heart treatment.
SGTC_2862 9027634 71.43 µM -1.07774861597351 0.110156002915426 no 2996 0.140572978117351 4119 5012562
SGTC_2277 7947813 106.88 µM -1.08096497222059 0.10946718967174 no 2997 0.139856347599519 4229 1246798
SGTC_528 3492-0019 172 µM -1.08242420298876 0.109155703710763 no 2998 0.139532039302882 4174 2869262
SGTC_1486 3970-0793 4.53 µM -1.08395997568793 0.108828567615126 no 2999 0.139191272679843 4198 2844330
SGTC_3028 9087778 49.47 µM -1.08841837743126 0.107882875194982 no 3000 0.13820522591793 4160 17217395
SGTC_445 e6 berbamine 66 µM -1.0899180630084 0.107566104009745 no 3001 0.137874619523146 4213 6610268 A calcium/calmodulin antagonist.
SGTC_1613 st002381 52.1 µM -1.09038896653639 0.107466775789301 no 3002 0.137770920014719 4160 551167
SGTC_922 1866-0035 480 µM -1.09087286900672 0.107364774573231 no 3003 0.137664413415462 4108 3156169
SGTC_2258 7960471 200 µM -1.09368428100912 0.106773540855282 no 3004 0.137046735335365 4225 2974708
SGTC_2029 5175081 200 µM -1.09380601595626 0.106747993438468 no 3005 0.137020032537232 4144 1380876
SGTC_947 3447-0010 211 µM -1.09399227484876 0.106708913500821 no 3006 0.13697918316727 4144 748350
SGTC_833 3852-0053 558 µM -1.09531812841024 0.106431027651722 no 3007 0.136688644055157 4260 3123681
SGTC_1010 4112-3296 15.2 µM -1.09544815722331 0.106403803053743 no 3008 0.136660173072476 4266 704384
SGTC_1665 st014639 11.4 µM -1.09770012568899 0.105933097816797 no 3009 0.136167727435829 4237 981133 YIL048W NEO1
SGTC_2630 antimycin a 100 µM -1.09937394006035 0.105584214241753 no 3010 0.13580249643212 4140 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1965 Pectolinarigenin 58.4 µM -1.09952358674569 0.105553062959895 no 3011 0.135769875807025 4162 5320438 An anti-inflammatory.
SGTC_2675 theaflavin digallate 100 µM -1.09994074801169 0.105466259452701 no 3012 0.135678969541691 4131 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -1.10100452292595 0.105245141385745 no 3013 0.135447344337349 4239 91467 include heat shock
SGTC_526 4469-0568 170 µM -1.10105844009623 0.105233943009068 no 3014 0.135435611690436 4143 2901964
SGTC_1960 st011366 51.8 µM -1.1019396790243 0.105051035461463 no 3015 0.135243948392739 4197 3972846
SGTC_892 0929-0076 29 µM -1.10503527687549 0.104410345648082 no 3016 0.134572151817038 4173 5751038
SGTC_2241 6772625 37.8075 µM -1.10767002187518 0.103867272081758 no 3017 0.134002175323154 4039 2285411
SGTC_3290 9121031 71.43 µM -1.1080614115107 0.103786773958097 no 3018 0.133917647409474 4215 17014854
SGTC_3198 9112019 49.47 µM -1.10972143147386 0.103445856359202 no 3019 0.133559542384899 4251 45595555
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -1.11255882963764 0.102865024423624 no 3020 0.132948975330726 4176 689007
SGTC_2725 haloperidol 53.21 µM -1.11259192247085 0.102858264135968 no 3021 0.132941865586831 4138 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1154 4088-0362 150 µM -1.11399197591074 0.102572553336937 no 3022 0.132641314516564 4199 6618304
SGTC_2653 dihydrofissinolide 100 µM -1.11437782866612 0.10249391334935 no 3023 0.132558565402833 4244 6857746
SGTC_3326 9140064 16.379 µM -1.11498878320167 0.102369485423529 no 3024 0.132427614222987 4112 1868434
SGTC_2502 avocadyne acetate 18.59 µM -1.11589591780337 0.102184939711037 no 3025 0.132233344698022 4146 3952079
SGTC_2659 sanguinarine 24.21 µM -1.11666213636734 0.102029250324117 no 3026 0.132069406502495 4158 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_1335 1486-0900 202 µM -1.11701659072898 0.101957286498629 no 3027 0.131993615772945 4203 X1335
SGTC_914 3820-6779 408 µM -1.11745251490259 0.101868832755488 no 3028 0.131900446007846 4159 2893481
SGTC_3074 9116018 49.47 µM -1.11777957809954 0.101802504768325 no 3029 0.131830572814946 4270 17027303
SGTC_2170 morpholine 200 µM -1.1180028487617 0.101757243830082 no 3030 0.13178288834096 4246 121171 Reacts with secondary amines.
SGTC_1982 st072467 71.9 µM -1.12192547251961 0.10096444637019 no 3031 0.13094706455864 4186 3163533
SGTC_1754 st042065 16.137 µM -1.12603374738453 0.100138964793756 no 3032 0.130075617558428 4002 1126236 YIL048W NEO1
SGTC_3325 9138760 55.175 µM -1.12686343326921 0.0999728545340666 no 3033 0.129900112926001 4148 43844959
SGTC_262 fenpropimorph 62.5 µM -1.12962663469 0.099421088941509 no 3034 0.129316791510862 4194 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1712 st032288 53.4 µM -1.13075391893829 0.0991966293974109 no 3035 0.129079340068447 4079 2883011
SGTC_667 1498-1044 59 µM -1.130968211913 0.0991540023374772 no 3036 0.129034235559773 4235 6739982
SGTC_1016 4226-1401 38 µM -1.13759734873018 0.0978419470463233 no 3037 0.127644327110783 4193 2901613
SGTC_1735 st034310 56.75 µM -1.14117482751995 0.0971391925093826 no 3038 0.126898588702527 4292 871153
SGTC_232 clozapine 119 µM -1.14982318108405 0.0954556384355926 no 3039 0.125108352767186 4195 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_658 3253-0951 102 µM -1.15004037853423 0.0954136353488449 no 3040 0.125063620425537 4237 1184878
SGTC_124 0136-0217 7.121 µM -1.15081010508025 0.0952648900549355 no 3041 0.12490518332492 4282 3976905
SGTC_1917 st066507 28.5 µM -1.15124728690527 0.09518048320668 no 3042 0.124815258222908 4192 3156428
SGTC_729 4092-0585 94.1 µM -1.15189035948631 0.0950564250624111 no 3043 0.124683065128281 4245 2169061
SGTC_1608 st001473 40.5 µM -1.15201826802665 0.0950317638336465 no 3044 0.124656783304837 4190 7292267
SGTC_292 k038-0015 474 µM -1.15496212280712 0.0944654797409618 no 3045 0.12405296887097 4244 46368540
SGTC_835 0312-0010 67.2 µM -1.15499649682864 0.0944588822327783 no 3046 0.124045930519654 4240 1626196
SGTC_127 0180-0333 59.125 µM -1.15511593373065 0.0944359609940539 no 3047 0.124021477046624 4152 771601
SGTC_2805 7950783 58.44 µM -1.15552015239749 0.0943584174693103 no 3048 0.123938742473875 4260 1178958 YDL195W SEC31
SGTC_2776 terbinafine 19.92 µM -1.1556638119061 0.0943308697759816 no 3049 0.123909347872563 4264 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1461 k072-0203 53.8 µM -1.15700655873685 0.0940736756387075 no 3050 0.123634840359594 4152 5418714
SGTC_2307 7538926 6.34 µM -1.15716757684389 0.0940428684775424 no 3051 0.123601950872988 4205 96582
SGTC_2972 9093619 59.92 µM -1.16045902403691 0.0934147551556806 no 3052 0.122930983767763 4203 25236256
SGTC_1298 1079-1278 263 µM -1.1604724645319 0.0934121966481109 no 3053 0.12292824914565 4219 2840950
SGTC_2785 7756463 72.73 µM -1.16087387828781 0.0933358081303382 no 3054 0.122846596594056 4209 2201551
SGTC_1565 sinapyl alcohol 95.1 µM -1.16962724679247 0.0916815107843517 no 3055 0.121075503770311 4275 5280507 A phenol propionate derived from cinnamic acid.
SGTC_3113 9123498 49.47 µM -1.17048710253551 0.0915201860848622 no 3056 0.120902500721645 4371 8897275
SGTC_175 3793-3120 23.7 µM -1.17524784212308 0.0906307894798883 no 3057 0.119947787428899 4258 5322297
SGTC_461 N-acetylfarnesylcysteine 136 µM -1.17625546093357 0.090443372521515 no 3058 0.119746403994866 4319 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2931 9014674 55.67 µM -1.17865509359542 0.0899982001185074 no 3059 0.119267771991677 4224 2996810
SGTC_1168 k815-0004 80.5 µM -1.18135594761987 0.0894990960222593 no 3060 0.118730675170143 4235 642433
SGTC_2197 6588183 93.1375 µM -1.18191483287477 0.0893960744173883 no 3061 0.118619747922722 4228 884136
SGTC_872 0588-0139 234 µM -1.18548352765613 0.0887403214504969 no 3062 0.117913161863437 4226 2047100
SGTC_1396 3511-0007 98.6 µM -1.18721606598566 0.0884232596124793 no 3063 0.117571202656431 4284 X1396
SGTC_338 4055-0136 114 µM -1.18740803170453 0.0883881810843187 no 3064 0.117533356730938 4262 2900563
SGTC_1458 k015-0034 6.33 µM -1.18830145332857 0.0882250596350636 no 3065 0.117357332678261 4298 3598957
SGTC_1241 0364-0022 50.8 µM -1.1889345150343 0.0881096107553614 no 3066 0.117232718421961 4278 4563895
SGTC_976 1348-1067 47.6 µM -1.18914807805248 0.0880706895564709 no 3067 0.117190701021828 4281 5310671 YGL099W LSG1
SGTC_955 1216-0110 33 µM -1.18984868855735 0.0879430954643631 no 3068 0.117052934500473 4251 3619719
SGTC_2662 daunorubicin 22.37 µM -1.19018967884839 0.0878810447409851 no 3069 0.11698592444801 4151 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3184 9108758 49.47 µM -1.19076301843365 0.0877767865426908 no 3070 0.116873315329961 4299 902885
SGTC_1437 4092-1038 11.6 µM -1.19310269544865 0.0873522873686988 no 3071 0.116414578006562 4317 3977136
SGTC_2838 9002687 71.43 µM -1.19360370784164 0.0872615857633925 no 3072 0.116316511451977 4269 6457060
SGTC_994 3910-0338 138 µM -1.19594389909607 0.0868388564971354 no 3073 0.115859226245106 4348 3479481
SGTC_756 0508-1999 28.3 µM -1.19762851516183 0.086535498012794 no 3074 0.115530834950803 4304 6753853
SGTC_1990 st072050 59.8 µM -1.19790507947444 0.086485771287033 no 3075 0.115476986038375 4275 17233948
SGTC_726 3448-4391 34.2 µM -1.20458712952679 0.0852908119724202 no 3076 0.114181363863519 4390 1356692
SGTC_3300 9124615 50.48 µM -1.21171566190035 0.0840296903349169 no 3077 0.112810620878695 4333 24824903
SGTC_3077 9117319 49.47 µM -1.2118156758916 0.0840120968138596 no 3078 0.112791473160819 4272 17154678
SGTC_2961 9083290 32.55 µM -1.21257640481096 0.0838783670502203 no 3079 0.112645907256305 4239 17741490
SGTC_3352 9151559 45.5865 µM -1.21314049393902 0.0837793081819663 no 3080 0.112538055146891 4292 17159339
SGTC_1386 3228-0095 33.8 µM -1.2152853396826 0.0834034571594184 no 3081 0.112128640696793 4306 870181
SGTC_2210 7115885 190.385 µM -1.2175258640678 0.0830121948448999 no 3082 0.111702100977542 4399 2927039
SGTC_1117 retinoic acid 1.10837 µM -1.21940161733285 0.0826856954807126 no 3083 0.1113458981912 4341 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2360 9040895 200 µM -1.2216035983611 0.0823036461818788 no 3084 0.110928783609885 4334 4914414
SGTC_383 2324-0395 7.37 µM -1.22307859022138 0.0820484758161201 no 3085 0.110650007109614 4299 3146421
SGTC_1052 3253-3998 198 µM -1.22596825878351 0.0815502978405275 no 3086 0.110105309975955 4246 5450317
SGTC_479 n-linoleoylglycine 10 µM -1.22706365079153 0.081362049949446 no 3087 0.109899334240106 4355 6433346 An anti-infammatory.
SGTC_777 1315-0167 517 µM -1.22847524026136 0.0811199457438095 no 3088 0.109634309220465 4334 4221767
SGTC_850 0388-0143 75.9 µM -1.2290685397961 0.0810183503120264 no 3089 0.109523054685439 4288 67273
SGTC_690 glyoxal 20.3 µM -1.22971677037942 0.0809074584123999 no 3090 0.109401592279705 4109 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_1681 tripelennamine 100 µM -1.23307708453846 0.0803344499604341 no 3091 0.108773503037654 4244 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1761 st044296 37 µM -1.23777160294071 0.079539071753013 no 3092 0.10790038032948 4305 1826700
SGTC_1649 st011737 51.3 µM -1.23943656589915 0.0792584181499499 no 3093 0.107591933448248 4325 1761035
SGTC_1966 st070145 16.1 µM -1.24248906465011 0.0787458235068238 no 3094 0.107028086346367 4302 3748532
SGTC_826 1683-5028 118 µM -1.2428711575833 0.0786818373818727 no 3095 0.106957657818923 4356 722377
SGTC_2202 7226349 200 µM -1.24625916755417 0.0781161963442006 no 3096 0.106334631660239 4302 844334
SGTC_2712 st079126 47.7 µM -1.24650793813456 0.0780747850364361 no 3097 0.106288988370815 4304 3152970
SGTC_1166 k206-0078 225 µM -1.24803935728886 0.0778202258577828 no 3098 0.106008322221783 4347 5404595
SGTC_2254 7938975 95.19 µM -1.24837212234095 0.0777649956006792 no 3099 0.105947406617089 4390 2969277
SGTC_2368 9071271 200 µM -1.25035616689226 0.0774363136887445 no 3100 0.105584734590167 4316 27209959
SGTC_2145 5634607 200 µM -1.25037133711677 0.0774338046211732 no 3101 0.105581965022299 4304 308662
SGTC_154 3389-1638 511.116 µM -1.25716159738563 0.0763169223127399 no 3102 0.104347562999949 4330 5238686
SGTC_118 0083-0097 135.343 µM -1.25926293429825 0.0759737837887784 no 3103 0.103967688259749 4310 5207356
SGTC_2923 7992654 58.14 µM -1.26210518976204 0.0755115273911002 no 3104 0.103455469035179 4328 2985126
SGTC_1839 st053978 48 µM -1.26347195105402 0.0752900057320806 no 3105 0.103209810322471 4361 3788398
SGTC_1575 cyproterone acetate 48 µM -1.26353955350745 0.0752790617467141 no 3106 0.103197670606981 4346 9880 An androgen receptor antagonist and liver toxin.
SGTC_2127 5253358 187.912 µM -1.26775095223314 0.074599677603341 no 3107 0.102443451386656 4245 20612
SGTC_2236 dapsone 200 µM -1.26787712412159 0.0745793959550516 no 3108 0.102420917270807 4335 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_904 1141-0088 396 µM -1.27325608135329 0.0737186578490573 no 3109 0.101463592906516 4351 1378119
SGTC_1722 st034304 3.6505 µM -1.27545014567531 0.0733697531395968 no 3110 0.101074979661368 4297 4036148 YLR033W RSC58
SGTC_510 ag-490 170 µM -1.27554264382885 0.0733550716840091 no 3111 0.101058620229182 4477 5328779
SGTC_3005 9076496 71.4286 µM -1.27597316628572 0.0732867680356001 no 3112 0.10098250245184 4314 21368410
SGTC_2680 butyl paraben 22.24 µM -1.27670801358849 0.0731702947699898 no 3113 0.100852675612628 4449 7184 An antifungal and steroid mimetic.
SGTC_1269 0831-0796 3.05 µM -1.28129238561413 0.0724468675734005 no 3114 0.100045493199879 4379 927758
SGTC_3332 9141069 11.198 µM -1.28544884383474 0.0717957142275896 no 3115 0.0993177411011145 4304 17332883
SGTC_1063 disulfiram 1.84 µM -1.28675201224389 0.0715924860866291 no 3116 0.0990903689349277 4384 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1024 4507-0395 26 µM -1.28760888822201 0.0714590976318817 no 3117 0.0989410718882873 4411 4201836
SGTC_287 k060-0039 29.6 µM -1.29526536204931 0.0702756795296573 no 3118 0.0976143519082614 4398 5861974
SGTC_1475 4092-1048 11.7 µM -1.29966148030893 0.069603040370288 no 3119 0.0968585089939681 4366 2881759
SGTC_1908 st060353 56.5 µM -1.30428852619636 0.0689004333370446 no 3120 0.0960676129476633 4412 4227716
SGTC_2459 5811157 9.22 µM -1.3045222847893 0.068865083212665 no 3121 0.0960277832157575 4318 2870684 YBR192W RIM2
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -1.30854979755773 0.0682582163722863 no 3122 0.0953434479059145 4370 1377
SGTC_347 4534-1311 26.2 µM -1.31267680924734 0.0676406470083989 no 3123 0.0946459376462191 4380 2862016
SGTC_2561 acetosyringone 100 µM -1.31416856253582 0.0674184851014445 no 3124 0.0943947426866561 4341 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3122 9126309 49.47 µM -1.31856105065692 0.066767600878917 no 3125 0.0936579511342765 4470 17591206
SGTC_298 1391-0729 10 µM -1.31980453711553 0.0665842254509931 no 3126 0.0934501431987792 4320 3237558
SGTC_1995 st072814 61.1 µM -1.31997993177447 0.0665583916158074 no 3127 0.0934208591680478 4355 5769371
SGTC_2952 9073731 13.78 µM -1.32058854229784 0.0664688096916715 no 3128 0.0933192976429529 4391 16457353
SGTC_2513 baicalein 25.65 µM -1.32661737651464 0.065586455101455 no 3129 0.0923176424045842 4384 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1380 2291-0730 164 µM -1.3276695766118 0.0654333947094504 no 3130 0.0921436441653428 4391 2999191
SGTC_24 0417-1663 219 µM -1.32859030887413 0.0652996859611248 no 3131 0.0919915855289582 4408 4329390
SGTC_2171 5739187 198.077 µM -1.33109018592137 0.0649377227539595 no 3132 0.0915796689075514 4333 2262761
SGTC_529 4076-0302 30.3 µM -1.33816743627905 0.0639214348818296 no 3133 0.0904209308515252 4356 5816522
SGTC_1171 0368-0077 21.4 µM -1.33822698608608 0.0639129363548386 no 3134 0.0904112273322234 4362 3239779
SGTC_3306 9127676 59.7925 µM -1.3385645963734 0.0638647716155792 no 3135 0.0903562290442091 4356 41905287
SGTC_1136 pergolide 1.05886 µM -1.34256479966675 0.0632962343310467 no 3136 0.0897064673927263 4331 47811 A dopamine receptor agonist.
SGTC_2600 tangeritin 87.95 µM -1.34661467994529 0.062724658522917 no 3137 0.0890521818711359 4300 68077 A bioactive flavone.
SGTC_1440 4100-1550 40 µM -1.3499712851564 0.0622539826977574 no 3138 0.0885125969088266 4409 742806
SGTC_2178 5812956 200 µM -1.3517566737596 0.0620047535636367 no 3139 0.088226584211454 4371 5403383
SGTC_400 oxethazaine 37.5 µM -1.35323225529826 0.0617993597949186 no 3140 0.0879907218647202 4428 4621 A local anesthetic.
SGTC_459 nigericin 15.3 µM -1.35426483534045 0.0616559458223146 no 3141 0.0878259503448295 4452 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_918 glabranin 770.725 nM -1.35578455449456 0.0614453464359845 no 3142 0.0875838635265429 4412 124049 Also referred to as licorice root.
SGTC_2056 5235370 200 µM -1.36045047784077 0.0608022625871232 no 3143 0.0868437070169631 4324 5511916
SGTC_1096 rimcazole 32.2 µM -1.36856739598369 0.0596960988442702 no 3144 0.0855672707143371 4339 18528119 A dopamine reuptake inhibitor.
SGTC_3148 9097893 49.47 µM -1.37001629827583 0.0595003131752818 no 3145 0.0853409070204379 4381 17174100
SGTC_1161 k007-0610 110 µM -1.37148373937818 0.0593025357752436 no 3146 0.0851121045275768 4364 5843850
SGTC_2759 disulfiram 3.38 µM -1.37363855592511 0.0590130505711204 no 3147 0.0847769604721273 4331 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2424 5537928 59.2 µM -1.37409415454201 0.0589519861499526 no 3148 0.0847062269724471 4421 5382802
SGTC_785 1270-0111 65.3 µM -1.37848999789933 0.0583653498379859 no 3149 0.0840260269340052 4341 6741994
SGTC_2726 cimetidine 79.27 µM -1.38315986301715 0.0577471774465528 no 3150 0.0833079268056119 4402 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2357 9067248 200 µM -1.38489034052469 0.0575194174814289 no 3151 0.083043000550361 4375 9150235
SGTC_1849 st056239 19.2 µM -1.38520015207369 0.0574787157446783 no 3152 0.0829956371157403 4419 5393181
SGTC_671 0560-0003 407 µM -1.38657710027385 0.0572980921445193 no 3153 0.0827853775536206 4357 3238678
SGTC_2903 5923464 63.88 µM -1.38693954032113 0.0572506227675001 no 3154 0.0827300997621934 4440 2876576
SGTC_1567 st069303 68.4 µM -1.39072604764184 0.0567565462851006 no 3155 0.0821542578996542 4450 5581319
SGTC_1108 betulinic acid 729.144 nM -1.3971860953078 0.0559213766560989 no 3156 0.0811788084707675 4417 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_531 3788-1495 174 µM -1.40322207630926 0.0551498210152319 no 3157 0.0802753132174406 4427 2896655
SGTC_1705 st027868 56.3335 µM -1.40987905912273 0.0543086629398503 no 3158 0.0792876985060567 4374 292948
SGTC_389 tpck 16.7 µM -1.41115199299182 0.0541489805677103 no 3159 0.0790999010243356 4478 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_770 0389-1121 67.2 µM -1.41315514196351 0.0538984495153815 no 3160 0.0788050564086363 4489 6753108
SGTC_346 4513-0042 7.16 µM -1.41450468388406 0.0537301822381243 no 3161 0.0786068865515532 4385 2827372
SGTC_2475 5812728 15.03 µM -1.41970874916609 0.053085207157768 no 3162 0.0778462449683372 4393 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1369 1866-0067 208 µM -1.41971681651827 0.0530842121031927 no 3163 0.0778450701722424 4461 3531355
SGTC_615 k087-0205 167 µM -1.42423199167264 0.0525296116633863 no 3164 0.0771896634512752 4475 9642773
SGTC_105 0111-0055 734.78 µM -1.43165821215303 0.0516274596462374 no 3165 0.0761208305647191 4473 5179370
SGTC_1366 1683-0113 21.9 µM -1.43178762304477 0.0516118484486943 no 3166 0.0761023052388687 4444 708623
SGTC_2274 7947094 46.08 µM -1.43206172011334 0.051578795746425 no 3167 0.0760630792446036 4410 2971028
SGTC_1707 st032323 6.317 µM -1.43585367547092 0.0511232578974041 no 3168 0.0755219912861383 4282 3132057 YMR211W DML1
SGTC_178 4092-0806 87.505 µM -1.43878950742411 0.0507727721312503 no 3169 0.0751050850586364 4346 2169044
SGTC_1260 0700-1617 7.75 µM -1.44163775940949 0.0504345730457202 no 3170 0.0747022952248782 4434 2853078
SGTC_2964 9083345 53.42 µM -1.44174045784474 0.0504224123269761 no 3171 0.0746878028215321 4429 17741579
SGTC_2485 5633444 17.78 µM -1.44544827914468 0.049984924856125 no 3172 0.0741660053798813 4437 5724239
SGTC_1070 indatraline 8.81 µM -1.45202041588479 0.0492169179287522 no 3173 0.0732479643128591 4526 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_1683 st010134 710 nM -1.4547868555921 0.0488964684549847 no 3174 0.0728641391186317 4436 3818134
SGTC_1362 1611-0397 101 µM -1.45483172448151 0.0488912848566641 no 3175 0.0728579265707421 4452 27816
SGTC_2993 9054257 71.4286 µM -1.45605314966202 0.0487503450461807 no 3176 0.0726889637273472 4388 6470217 YGL055W OLE1
SGTC_332 4112-0506 40.9 µM -1.45724406216666 0.0486132389339348 no 3177 0.0725245108522795 4453 2790355
SGTC_348 k064-0012 10.7 µM -1.45784982789863 0.0485436173567214 no 3178 0.0724409702084461 4422 5066323
SGTC_2095 5432005 200 µM -1.45935617594684 0.0483708360743045 no 3179 0.0722335506272289 4479 783734
SGTC_2083 5306046 65.942 µM -1.4602958471516 0.0482633031724491 no 3180 0.0721043914535369 4457 539837
SGTC_297 0986-0032 24 µM -1.46068933633724 0.0482183304026381 no 3181 0.0720503584112395 4440 2847425
SGTC_1107 amlodipine 47 µM -1.46129423508473 0.0481492605486231 no 3182 0.0719673556338594 4073 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_765 1319-0117 244 µM -1.4661770128015 0.0475946191938211 no 3183 0.0713000346572027 4448 3487746 YGL099W LSG1
SGTC_1436 4092-1007 8.32 µM -1.46918049860209 0.0472559990505716 no 3184 0.0708919191410037 4470 2881121
SGTC_2979 9012552 45.46 µM -1.47430753874327 0.0466824281613678 no 3185 0.0701994031588006 4487 17100905
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.47717448793709 0.0463641407158988 no 3186 0.0698144353005883 4532 165521
SGTC_1438 4092-1045 4 µM -1.49078424306695 0.0448768841725475 no 3187 0.0680090749883688 4495 1351342
SGTC_1128 3448-9350 235 µM -1.49525353150703 0.044396948804678 no 3188 0.0674241437610868 4484 619386
SGTC_504 lovastatin 124 µM -1.49818648360654 0.0440842470330215 no 3189 0.0670424031848627 4499 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_1747 st037496 66.6 µM -1.4987685925366 0.0440223961803813 no 3190 0.0669668375500698 4450 723305
SGTC_3212 9128307 49.47 µM -1.49877208228315 0.0440220255952658 no 3191 0.0669663847323795 4399 27243542
SGTC_1080 nisoldipine 24.4 µM -1.49969118475813 0.0439245112962781 no 3192 0.0668472075410486 4500 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_559 1550-0661 158 µM -1.50066978940637 0.0438208755526111 no 3193 0.0667204953251618 4530 5830875
SGTC_2727 riluzole 51.77 µM -1.50578611300389 0.0432822562153283 no 3194 0.0660610446903892 4539 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2092 5303694 80.6725 µM -1.51215388028288 0.0426193726787377 no 3195 0.0652473602866941 4512 1963699
SGTC_752 1896-0090 130 µM -1.51347940160441 0.0424824236155319 no 3196 0.0650789647532731 4494 772567
SGTC_1731 st035964 63 µM -1.51734726860925 0.0420848401236392 no 3197 0.0645895149257195 4419 6739575
SGTC_744 1594-0068 283 µM -1.51771496403599 0.0420472014674789 no 3198 0.0645431350301407 4491 668392
SGTC_119 0121-0043 24.815 µM -1.51884242326012 0.0419319604305377 no 3199 0.0644010822973991 4517 1092378
SGTC_1275 0867-0008 21.1 µM -1.52313019098727 0.0414960280620127 no 3200 0.0638630684315108 4484 3422836
SGTC_1931 st074438 57.1 µM -1.52677632425017 0.0411282255129689 no 3201 0.0634083204007253 4513 2787313
SGTC_481 bay k-8644 50 µM -1.53635236562943 0.0401748215867467 no 3202 0.0622259913954754 4485 2303 A calcium channel antagonist.
SGTC_1669 st015249 58.4 µM -1.53714539898017 0.040096677777626 no 3203 0.0621288538259762 4633 722793
SGTC_1355 1499-0035 1.68 µM -1.54510789484046 0.0393188958701014 no 3204 0.0611600838426498 4519 1548538
SGTC_2775 cyproheptadine 69.59 µM -1.54646668752764 0.039187402471635 no 3205 0.0609959496644053 4515 2913 A selective serotonin reuptake inhibitor.
SGTC_2405 ticlatone 3.52 µM -1.54740660104789 0.0390966545367046 no 3206 0.0608826152464997 4333 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1425 4048-4433 7.33 µM -1.55100303976079 0.0387509995358336 no 3207 0.0604504777476666 4589 23734946
SGTC_527 4476-4215 268 µM -1.55218547336341 0.0386379006979723 no 3208 0.0603089254633825 4510 4418754
SGTC_900 1112-0045 141 µM -1.55423554923507 0.0384424500508645 no 3209 0.0600641203716581 4424 56211 YIL048W NEO1
SGTC_1963 st076565 50.3 µM -1.55694898928237 0.0381849954443268 no 3210 0.0597412984815491 4536 4914280
SGTC_1400 3771-8998 51.5 µM -1.55752567395624 0.0381304604571739 no 3211 0.0596728649413833 4476 670767
SGTC_1892 st058411 7.36 µM -1.56302472824497 0.0376136193247082 no 3212 0.0590233893001496 4528 3934738
SGTC_407 eburnamonine 100 µM -1.56384609636757 0.0375369144224943 no 3213 0.0589268579569783 4376 3195
SGTC_233 rapamycin 362 pM -1.56530470445524 0.037401014588806 no 3214 0.058755740295498 4528 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_3303 9125618 40.5795 µM -1.56867205735146 0.0370888097379685 no 3215 0.0583621863753832 4513 22695467
SGTC_3241 9133421 49.47 µM -1.57129707275792 0.0368469110302729 no 3216 0.0580568304195995 4615 17018221
SGTC_1466 k213-0079 57.5 µM -1.5719182984613 0.0367898534220851 no 3217 0.0579847501323027 4520 3657981
SGTC_1073 triclabendazole 3.09 µM -1.5766891748264 0.0363540677611427 no 3218 0.0574335312186759 4574 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_1667 st014849 34.6 µM -1.6044016624618 0.0339055558296743 no 3219 0.0543127724049827 4635 5348460
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.60500676321281 0.0338536445563539 no 3220 0.0542461581455496 4576 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_954 1189-0853 2.85 µM -1.60512204775581 0.0338437617751156 no 3221 0.0542334740491834 4489 2828194
SGTC_60 0986-0278 202 µM -1.61236649931127 0.0332274746441592 no 3222 0.053441105183557 4499 3110598
SGTC_819 1013-0258 27.7 µM -1.61801559425836 0.0327533450325 no 3223 0.0528296185036849 4564 5753198
SGTC_253 dyclonine 31.25 µM -1.62893121721746 0.0318529958230546 no 3224 0.051663790345756 4647 3180 An oral anasthetic.
SGTC_1027 k015-0025 8.67 µM -1.62897928933896 0.0318490763881884 no 3225 0.0516587016769105 4533 3598955
SGTC_2365 9042475 200 µM -1.63069363561578 0.0317095618578326 no 3226 0.0514774900913288 4583 6464479
SGTC_1393 3470-5649 58.2 µM -1.63327547950753 0.0315004030740522 no 3227 0.0512055357362222 4559 4108395
SGTC_2467 5474540 200 µM -1.63666408515864 0.0312276193416339 no 3228 0.0508503385902399 4547 5413519
SGTC_1749 st037932 54.2 µM -1.63981834049394 0.0309754595194194 no 3229 0.0505214718087084 4542 594497
SGTC_1902 st060212 70.5 µM -1.6505982621548 0.0301263714022928 no 3230 0.0494103169902253 4557 688944
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -1.6554793074795 0.029748308033394 no 3231 0.0489136552176229 4649 4620898
SGTC_2352 9027995 87.8 µM -1.65552816218139 0.0297445439617299 no 3232 0.0489087043354158 4538 2997347
SGTC_285 1486-1325 46 µM -1.66181545881254 0.029263418593282 no 3233 0.048274890844607 4607 22310230
SGTC_997 3996-0078 137 µM -1.66608640475187 0.0289402919324904 no 3234 0.0478481029855575 4615 735687
SGTC_1286 0929-0070 131 µM -1.67304542895498 0.0284201489026177 no 3235 0.0471591765875074 4619 1420408
SGTC_731 3966-0296 387 µM -1.67570951182808 0.0282230953522165 no 3236 0.046897552895002 4589 660956
SGTC_454 lyso-paf C-16 6.67 µM -1.69074624438373 0.0271320890610491 no 3237 0.0454426389750107 4588 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1518 st038567 90.8 µM -1.693631405791 0.026926829217284 no 3238 0.0451676731746266 4553 77966
SGTC_2729 fluphenazine 10.66 µM -1.69442473657176 0.0268706168250898 no 3239 0.0450923011467351 4558 3372 An atypical antipsychotic.
SGTC_1904 st060225 78 µM -1.69596536202575 0.0267617338370673 no 3240 0.0449462199986036 4577 66595
SGTC_624 k048-0052 28 µM -1.70172250718937 0.0263581060326223 no 3241 0.0444036995847437 4583 6835531
SGTC_2734 clemastine 41.6 µM -1.70282954147443 0.0262810791337109 no 3242 0.0442999863600423 4660 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_523 1934-0222 13.7 µM -1.73012014834727 0.0244408999121962 no 3243 0.0418044055619538 4576 1361595
SGTC_990 3985-0011 41.3 µM -1.73300082973547 0.0242531281799897 no 3244 0.0415477606581008 4575 5399565 YGL099W LSG1
SGTC_136 0097-0015 404.482 µM -1.7341282082802 0.0241799727270334 no 3245 0.0414476687397892 4595 4861337
SGTC_832 4083-0019 164 µM -1.73791513077518 0.0239355953680908 no 3246 0.0411128845839727 4635 1990758
SGTC_2464 5717415 7.67 µM -1.73897291966112 0.0238677062669806 no 3247 0.0410197632044372 4573 5285744
SGTC_2053 5265679 138 µM -1.74065742742018 0.0237599283597365 no 3248 0.0408718224395513 4522 764595
SGTC_2732 terfenadine 20 µM -1.74096155567512 0.0237405133463941 no 3249 0.0408451587649997 4674 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1721 st082152 9.2685 µM -1.77197243906919 0.0218296649338694 no 3250 0.0381995661886088 4569 5296051
SGTC_928 2764-0428 58.7 µM -1.77991612175052 0.0213616336155584 no 3251 0.0375448444315204 4630 662578
SGTC_1253 0550-0034 176 µM -1.78124189683637 0.0212843528300643 no 3252 0.0374364709569602 4604 5969915
SGTC_2422 chlorphenesin carbamate 384.24 µM -1.78335426188457 0.0211617094310193 no 3253 0.0372643268212331 4569 2724 A muscle relaxant with antifungal properties.
SGTC_1349 flufenamic acid 69 µM -1.79386471895513 0.0205603265731886 no 3254 0.036417381966051 4569 3371 A non-steroidal anti-inflammatory.
SGTC_1378 2093-0007 380 nM -1.79577346433571 0.020452680930672 no 3255 0.0362652762994175 4627 3618014
SGTC_246 cycloheximide 667 µM -1.80427155937638 0.0199792007304195 no 3256 0.0355943730149196 4586 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_975 1335-0046 28.5 µM -1.80651426565264 0.0198558081803602 no 3257 0.0354190239347853 4616 16486740
SGTC_404 fumagillin 50 µM -1.81228647882618 0.0195411948312624 no 3258 0.0349709713413225 4643 12015870 A methionine aminopeptidase binder.
SGTC_247 mechlorethamine 29.705 µM -1.81390337673009 0.0194538289301752 no 3259 0.0348463013937575 4622 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_496 calpeptin 138 µM -1.81520203417272 0.0193838990122653 no 3260 0.034746433610788 4611 73364 A calpain inhibitor.
SGTC_1578 josamycin 24.2 µM -1.81673886001884 0.0193014202699808 no 3261 0.03462855424355 4621 5282165 A P450 substrate.
SGTC_516 3992-2719 87.3 µM -1.81712175825433 0.0192809172665116 no 3262 0.0345992359153315 4542 5350887 YDR037W KRS1
SGTC_3282 9108498 15.4605 µM -1.81879679960739 0.0191914415018864 no 3263 0.0344712184248865 4611 16459645
SGTC_932 2857-0803 154 µM -1.82038405817533 0.0191069807795452 no 3264 0.0343502692178467 4618 674898
SGTC_606 k015-0008 38.6 µM -1.82491994659655 0.0188673585170854 no 3265 0.0340065553460892 4687 1970475
SGTC_2322 7413319 38.22 µM -1.82565830003664 0.0188285956914119 no 3266 0.0339508740688901 4564 1840400
SGTC_2984 9022109 38.96 µM -1.83235979616051 0.0184798619364783 no 3267 0.0334489168529306 4628 6459207
SGTC_396 dithiazanine 1.25 µM -1.83972529716564 0.0181029344767675 no 3268 0.0329042888154938 4616 10578 An antihelmenthic.
SGTC_905 2-aminofluorene 215 µM -1.8428055927568 0.0179472556348236 no 3269 0.0326786999789753 4651 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1232 0279-0259 161 µM -1.85590217324351 0.0172980350611436 no 3270 0.0317337515876974 4635 1560000
SGTC_1002 4049-0206 172 µM -1.86668936393872 0.0167784633963247 no 3271 0.0309724899483007 4636 4662749
SGTC_2138 5575593 77.673 µM -1.87971079047025 0.0161691138894377 no 3272 0.0300737520882979 4641 762213
SGTC_78 0336-0123 156.75 µM -1.89587038966591 0.0154393617803483 no 3273 0.0289885926154738 4550 6765896
SGTC_1513 0337-0559 19 µM -1.89758134383914 0.0153637782478059 no 3274 0.0288756269681238 4630 775073
SGTC_340 k038-0059 454 µM -1.90067349199103 0.0152279845782686 no 3275 0.0286723963561818 4651 23733424
SGTC_2353 9059630 146.67 µM -1.90658744877871 0.0149711392772113 no 3276 0.0282870158399106 4675 4779114
SGTC_1455 4262-0120 131 µM -1.93465260650156 0.013802421968815 no 3277 0.0265164699225701 4684 1529587
SGTC_250 brefeldin a 552.239 µM -1.93843233164748 0.0136511990957357 no 3278 0.0262852495360567 4636 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_244 nsc-207895 1.295 µM -1.93933000122673 0.0136154950758665 no 3279 0.0262305839965912 4538 42640
SGTC_2733 amorolfine 100 µM -1.94065676091474 0.0135628719561441 no 3280 0.0261499621684114 4768 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2016 5121758 140 µM -1.95180098610838 0.013127747892848 no 3281 0.0254809185873162 4582 2795203
SGTC_750 4073-0104 132 µM -1.96887022467702 0.0124846824842561 no 3282 0.0244839977715221 4384 22330957
SGTC_1226 3909-7979 35.4 µM -1.98024699524708 0.012071382769172 no 3283 0.0238378907653502 4664 6615510
SGTC_3163 9099914 49.47 µM -1.98870130212114 0.0117719839175081 no 3284 0.0233670910959085 4744 16268368
SGTC_417 st075190 100 µM -1.99454088252193 0.0115689644221329 no 3285 0.0230464884098958 4670 222757
SGTC_1919 st067113 52.3 µM -1.99580672016126 0.0115253593245087 no 3286 0.0229774825267098 4640 1268243
SGTC_924 2046-0044 21.3 µM -1.99702919625689 0.0114833834884742 no 3287 0.0229110057284615 4659 3623589
SGTC_525 k781-2675 26.7 µM -1.99737841542999 0.0114714168541207 no 3288 0.0228920453835313 4634 3651118 YDL195W SEC31
SGTC_3011 9081274 71.4286 µM -2.01814819702358 0.0107789094536685 no 3289 0.0217879146901903 4692 6625322
SGTC_1078 idebenone 36.1 µM -2.02620188728008 0.0105203413420428 no 3290 0.0213720501647108 4718 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_728 3030-5151 22.5 µM -2.03313916607165 0.01030196578543 no 3291 0.0210192325079214 4728 3125388
SGTC_306 1672-3436 11.6 µM -2.03552013857486 0.0102279326865305 no 3292 0.0208992821541056 4705 6797378
SGTC_157 1348-1695 65.819 µM -2.04722204611055 0.00987078354320424 no 3293 0.0203181438846798 4624 5380510
SGTC_1709 st033179 39.1045 µM -2.0631202814012 0.00940303365088598 no 3294 0.0195506008459925 4701 573381
SGTC_2144 5628481 200 µM -2.08234722494112 0.00886334175968374 no 3295 0.0186553826210389 4701 2818399
SGTC_420 mitomycin C 81.9 mM -2.12173150769161 0.00784194886064971 no 3296 0.0169301455858102 4698 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_55 0767-0285 6.563 µM -2.12338479916648 0.00780143500170959 no 3297 0.0168608099692412 4676 3116166
SGTC_473 2-arachidonoylglycerol 10 µM -2.13971286904498 0.0074111029884713 no 3298 0.0161889891968482 4606 5282280 An endocannabinoid.
SGTC_278 4092-0821 23.9 µM -2.14261038798063 0.00734366356289022 no 3299 0.0160721981666274 4688 877900
SGTC_520 3584-0023 682 µM -2.15604107506955 0.00703808106815913 no 3300 0.0155402289787941 4674 1340790
SGTC_1573 oleylamine 1.06 µM -2.16736356986515 0.00678924087167391 no 3301 0.0151035713908186 4706 5356789 An amine of the fatty acid oleic acid.
SGTC_1774 st048371 48.465 µM -2.16987604141045 0.00673508844163411 no 3302 0.0150081188912446 4713 4242727
SGTC_3296 9122258 64.045 µM -2.17720474787305 0.00657930375930773 no 3303 0.0147326471128907 4685 4730474
SGTC_401 neomycin 50 µM -2.20443741228912 0.00602798305107646 no 3304 0.0137467985065286 4725 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_3301 9125354 19.7965 µM -2.22428994296151 0.00565228192622404 no 3305 0.0130644714589108 4711 41905162
SGTC_1485 3909-9022 254 µM -2.2351231035547 0.00545616330232411 no 3306 0.012704633998158 4775 714516
SGTC_2296 7971656 126.45 µM -2.24080258057417 0.00535578058629301 no 3307 0.0125194328639439 4707 666570
SGTC_1696 st025591 34.7925 µM -2.24970289639013 0.00520177177171838 no 3308 0.012233905772631 4705 2787147
SGTC_1684 st024538 14.6195 µM -2.2514399016968 0.0051721788339688 no 3309 0.0121788446445311 4735 6732859
SGTC_2315 7733312 200 µM -2.26053141624739 0.00501971994173607 no 3310 0.0118941444451676 4684 726316
SGTC_1670 st016595 4.04 µM -2.28154189250324 0.00468259915409879 no 3311 0.0112582003524816 4764 597879
SGTC_2154 5570129 200 µM -2.29389435074879 0.00449396575689495 no 3312 0.0108982839997569 4752 673366
SGTC_1300 1094-0077 113 µM -2.30027325531725 0.00439923599149062 no 3313 0.0107163719399848 4747 5532636
SGTC_1303 1160-0052 261 µM -2.30391520569703 0.0043459550497775 no 3314 0.0106137019816278 4706 3562476
SGTC_2140 5586273 200 µM -2.30923049769899 0.0042692284181473 no 3315 0.0104653970325107 4741 854421
SGTC_489 paxilline 115 µM -2.31228491373357 0.004225687739037 no 3316 0.0103809937520322 4716 105008 A toxic potassium channel blocker.
SGTC_1647 st011722 22.4 µM -2.31262087551181 0.00422092293151653 no 3317 0.0103717463773732 4744 2854783
SGTC_2460 5552655 174.22 µM -2.33871989336491 0.00386513838277001 no 3318 0.0096749674520897 4729 5401989
SGTC_747 3448-8087 38.7 µM -2.34124080877023 0.00383223833814802 no 3319 0.00960988297973916 4756 5168703
SGTC_1377 2944-0135 198 µM -2.34775298220695 0.0037484077618213 no 3320 0.00944352115112884 4730 1894137
SGTC_300 r073-0011 5.04 µM -2.35689785303941 0.00363346269093397 no 3321 0.00921415760906895 4757 2735780
SGTC_2293 7624732 200 µM -2.41319804577908 0.00299289248635102 no 3322 0.00790661227335251 4675 894453
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -2.47885451992154 0.00237564401070302 no 3323 0.00659025267001426 4751 2374 Ca(2+)-ATPase inhibitor.
SGTC_3167 9103034 49.47 µM -2.50166493441458 0.00218980652691214 no 3324 0.0061805425200222 4798 5127859
SGTC_957 1187-1561 14.1 µM -2.53638897651923 0.00193211166913904 no 3325 0.00560011254037038 4720 1538454
SGTC_2423 st077119 87.2 µM -2.54878457305431 0.00184701158034375 no 3326 0.00540495263131719 4698 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1481 3346-2004 36 µM -2.55440557244662 0.00180955641741034 no 3327 0.00531846384490405 4795 2770522
SGTC_1197 1601-0112 267 µM -2.57832389634152 0.00165777993455529 no 3328 0.00496404450894164 4765 7350313
SGTC_146 3448-8650 53.125 µM -2.58045222428192 0.00164485257633756 no 3329 0.00493355041276579 4742 2891488 YIL048W NEO1
SGTC_1206 3978-0017 132 µM -2.59539941225848 0.001556620427024 no 3330 0.00472405267346693 4749 3873677
SGTC_2266 7929956 200 µM -2.61242354595537 0.00146139873545739 no 3331 0.00449513990262575 4754 2967153
SGTC_614 0462-0418 107 µM -2.62046600892865 0.00141829010767711 no 3332 0.0043904841685907 4648 5188303
SGTC_1770 st043884 66.3 µM -2.67294909763578 0.00116432112210805 no 3333 0.0037593829187162 4773 670149
SGTC_120 rhodamine 6G 52.259 µM -2.70728010319461 0.00102149274992589 no 3334 0.0033918497376227 4773 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_730 1436-0052 41.2 µM -2.78003609415153 0.00077042619247234 yes 3335 0.00271764284102871 4786 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_753 1322-0200 289 µM -2.78661322650584 0.000750791073558125 yes 3336 0.00266310037114302 4790 5403907
SGTC_35 0133-0054 64.071 µM -2.7882321486029 0.000746029234859407 yes 3337 0.00264982758982091 4743 99677
SGTC_2570 licareol 100 µM -2.83041760279328 0.000631340631451847 yes 3338 0.00232436417499341 4762 443158
SGTC_1471 k673-0312 37 µM -2.83120217307812 0.000629370838868819 yes 3339 0.00231866993295311 4797 24099884
SGTC_2815 7968870 71.43 µM -2.84810857911395 0.000588279079389273 yes 3340 0.00219899584130552 4742 2977326 YHR190W ERG9
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -2.9119005766631 0.00045454575484347 yes 3341 0.001796184798444 4751 5355888
SGTC_2987 9018338 71.43 µM -2.97572506666192 0.000349426791871465 yes 3342 0.00146148389624874 4787 5055682
SGTC_2146 5545642 200 µM -2.98023653122183 0.000342926139844162 yes 3343 0.00144012944011599 4782 825326
SGTC_309 k408-0051 1.48 µM -3.0084660060317 0.000304735587008515 yes 3344 0.00131285087521323 4747 3640463
SGTC_613 3914-0030 117 µM -3.08657967913849 0.000218687809323539 yes 3345 0.00101236836925726 4710 1145395
SGTC_1459 k035-0031 35.7 µM -3.09283319475773 0.000212886476090513 yes 3346 0.000991277682803133 4738 3877128 YMR208W ERG12
SGTC_2572 astragaloside iv 100 µM -3.10948541076481 0.00019813152494867 yes 3347 0.00093706769891931 4779 45006101 An anti-inflammatory agent.
SGTC_1478 0453-0656 35.7 µM -3.17353611135459 0.000149826720649987 yes 3348 0.000752970835469189 4806 5258496
SGTC_303 1348-1668 34.2 µM -3.20294120361261 0.000131564408485005 yes 3349 0.000680158754211178 4803 5380509
SGTC_1231 0242-0792 125 µM -3.2054028864189 0.000130134247951385 yes 3350 0.000674367754014427 4796 3707635
SGTC_2428 5615643 7.78 µM -3.35792054158214 6.51583014484002e-05 yes 3351 0.000392655920517578 4795 2253075
SGTC_2853 9015042 58.44 µM -3.39777658680338 5.41262849410899e-05 yes 3352 0.000339679377558322 4780 6457456
SGTC_1484 3473-2379 286 µM -3.54395305334517 2.69545476045454e-05 yes 3353 0.000197087713703667 4807 671917
SGTC_69 0096-0274 206.684 µM -4.10352452775735 1.46192411897796e-06 yes 3354 2.03451645698615e-05 4795 6741392
SGTC_74 000s-0487 160.283 µM -6.73565963896344 8.10390360342001e-15 yes 3355 8.15939414839391e-12 4809 677548
SGTC_77 0828-0286 12.516 µM -7.02867968787015 5.6541098784772e-16 yes 3356 1.04248497964583e-12 4809 745345