SGTCid condition conc unit YBR285W|YBR285W.score YBR285W|YBR285W.strain.pval YBR285W|YBR285W.strain.significant YBR285W|YBR285W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_3147 9097027 49.47 µM 7.8120530055975 2.70692747306239e-13 yes 1 2.81319439568754e-15 2 25236841
SGTC_929 2805-0021 398 µM 7.15743982916476 1.93918593315192e-11 yes 2 4.10988243920322e-13 1 3098024
SGTC_3146 9095609 49.47 µM 6.19622628748826 5.35561762182486e-09 yes 3 2.89164823196962e-10 1 17173999
SGTC_3154 9100113 49.47 µM 5.77374511558043 4.96323346876382e-08 yes 4 3.87643434041793e-09 8 25237525
SGTC_1377 2944-0135 198 µM 5.69085384783831 7.54940711364526e-08 yes 5 6.32028348840551e-09 14 1894137
SGTC_628 1636-0253 16 µM 5.47580175013863 2.18234081800454e-07 yes 6 2.17767543842392e-08 12 4456143
SGTC_1107 amlodipine 47 µM 5.3540453854986 3.91335103921663e-07 yes 7 4.30046359006144e-08 8 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1782 st039423 80.636 µM 5.00750362211665 1.92870184734123e-06 yes 8 2.7570257135388e-07 5 2068169
SGTC_1949 st076024 69.1 µM 4.98068103054089 2.17313277976887e-06 yes 9 3.16804497967923e-07 10 2921930
SGTC_1743 st037606 46.3785 µM 4.8484251330456 3.88007221429394e-06 yes 10 6.22227398373756e-07 10 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_888 0916-0002 6.97 µM 4.59183788397476 1.1466834339553e-05 yes 11 2.1967980444476e-06 33 2802138 YIL048W NEO1
SGTC_942 3253-1115 227 µM 4.57225415167297 1.24279008080388e-05 yes 12 2.41252594737445e-06 14 46497897
SGTC_898 1000-0849 28.3 µM 4.28122764997746 3.96071399000292e-05 yes 13 9.29325490923689e-06 2 6751807
SGTC_2624 nerol 100 µM 4.1971390065285 5.46542659473219e-05 yes 14 1.35154017642337e-05 7 637566 A natural product oil.
SGTC_2418 pentamidine 31.67 µM 4.05539408740926 9.28336429090722e-05 yes 15 2.5024923624198e-05 39 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_3156 9099931 49.47 µM 4.04898945983761 9.50460182600731e-05 yes 16 2.5719630560272e-05 6 18111053
SGTC_2622 2-methoxyxanthone 59.94 µM 3.9600089767093 0.000131384645453029 yes 17 3.74734730403118e-05 19 71034 A hepatoprotective.
SGTC_1914 st062367 72.6 µM 3.94552770321968 0.000138409103434952 yes 18 3.98122124785686e-05 20 978205
SGTC_2106 5357045 167.29 µM 3.93876689920839 0.000141807726497407 yes 19 4.09507261168347e-05 18 668842
SGTC_1548 st061468 90.8 µM 3.84750567004299 0.000196036801770098 yes 20 5.96632582196408e-05 9 390799
SGTC_2684 capsaicin 100 µM 3.74515553519947 0.000279630465551232 yes 21 9.01410258306969e-05 19 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2001 4023502 57.655 µM 3.70893086727234 0.000316444147518598 yes 22 0.000104068120913208 25 108941 YCR052W RSC6
SGTC_2419 paclitaxel 166.5 µM 3.61925492803291 0.000427848406507506 yes 23 0.000147726234797389 57 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1788 fluconazole 20 µM 3.60036667475461 0.000455535613785375 yes 24 0.000158884369194147 68 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_885 0865-0106 16.8 µM 3.59826300268205 0.000458719948006884 yes 25 0.000160174791740148 36 2793380
SGTC_1173 0443-0020 122 µM 3.57268654813296 0.000499120692853696 yes 26 0.000176668802947773 54 5331295
SGTC_3132 9126706 49.47 µM 3.32653372318602 0.00109487589196465 no 27 0.000439666894584657 49 850858
SGTC_2844 9010103 25.97 µM 3.3264565371955 0.0010951372973396 no 28 0.000439788678683237 52 2480525
SGTC_2807 7945238 51.95 µM 3.29498599086082 0.00120661344474159 no 29 0.000492132932583105 58 17148797
SGTC_1928 4'-methoxychalcone 40.3 µM 3.2826309656479 0.00125314785776665 no 30 0.000514216007085047 32 641818
SGTC_1011 4112-3381 17.4 µM 3.2742725201003 0.00128555431381223 no 31 0.000529671966905321 67 2877139
SGTC_3351 9150312 21.596 µM 3.2542114672266 0.00136648336661114 no 32 0.000568538012793826 57 4904905
SGTC_520 3584-0023 682 µM 3.24912775112234 0.00138771794072622 no 33 0.000578797388000499 54 1340790
SGTC_2680 butyl paraben 22.24 µM 3.2410404125194 0.0014221203931428 no 34 0.000595471495591465 26 7184 An antifungal and steroid mimetic.
SGTC_2618 avocadyne 43.43 µM 3.23725265066282 0.00143849926722179 no 35 0.000603432559112011 56 3015189
SGTC_1244 0416-0015 52.5 µM 3.21423409187314 0.00154179321853101 no 36 0.000653964974691179 74 96201
SGTC_1374 2889-5571 141 µM 3.21094673673649 0.00155708468449557 no 37 0.000661492269252892 81 2853281
SGTC_1330 1469-0054 61.8 µM 3.13573542508011 0.00194695343952363 no 38 0.000857118886247676 41 7102664
SGTC_2824 7998404 51.95 µM 3.13067983085825 0.00197609924192756 no 39 0.000872010921338695 60 837851
SGTC_2197 6588183 93.1375 µM 3.06311152938376 0.00240553558569653 no 40 0.00109524202088814 47 884136
SGTC_427 1354-0053 47.3 µM 3.0625095232235 0.00240971476310104 no 41 0.0010974474566451 58 6813657
SGTC_3347 9188721 44.724 µM 3.03684482814616 0.00259410823051498 no 42 0.00119534245035454 53 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_1357 1503-1303 39.5 µM 3.03400034709305 0.00261531075573212 no 43 0.00120667076164664 92 292895
SGTC_750 4073-0104 132 µM 3.02266660452095 0.00270135496289635 no 44 0.00125279059128142 32 22330957
SGTC_1627 st003713 25.6 µM 3.01727120295548 0.0027432072565476 no 45 0.00127530752270801 148 16195070 YER133W GLC7
SGTC_3009 9080819 71.4286 µM 3.01669770026928 0.00274769017069446 no 46 0.00127772258868796 62 17027216
SGTC_1744 st037937 38.9 µM 3.01636746974086 0.00275027449155262 no 47 0.00127911511288163 66 1016152
SGTC_2280 7785178 200 µM 3.01572066564585 0.00275534261392936 no 48 0.00128184659444082 36 2954328
SGTC_1985 st071382 65.5 µM 3.00586763362225 0.00283359660152246 no 49 0.00132412125605391 52 6123237
SGTC_2405 ticlatone 3.52 µM 3.00520551255759 0.00283892644544278 no 50 0.00132700729508282 127 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1187 1391-0724 117 µM 2.99309774407828 0.00293799763520465 no 51 0.00138080644168927 60 6997986
SGTC_1422 4031-0024 15.5 µM 2.98784783218401 0.00298191512970522 no 52 0.00140474698545446 51 782427
SGTC_1460 k062-0059 9.15 µM 2.9796453117587 0.00305171730644283 no 53 0.00144291159265937 57 1373085
SGTC_2766 oltipraz 83.91 µM 2.96899324298628 0.00314456016753422 no 54 0.00149388583150619 72 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_612 0302-0167 22.4 µM 2.96841414056221 0.00314967970679391 no 55 0.00149670358555591 86 235821
SGTC_1423 4048-0112 5.59 µM 2.94333957372374 0.00337867458664277 no 56 0.00162346028366074 72 X1423
SGTC_3137 9097352 49.47 µM 2.94155356315629 0.00339554261995941 no 57 0.00163285179524918 99 44120435
SGTC_1956 st077085 54 µM 2.93009206533335 0.00350560400804539 no 58 0.00169430795390152 66 24208685
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 2.89946510734404 0.00381559105093455 no 59 0.00186899973685106 62 16486 A toxic proline analog.
SGTC_329 k048-0121 21.3 µM 2.89353422344035 0.0038783846854894 no 60 0.00190466387601642 54 6832902
SGTC_555 4296-0685 37 µM 2.86696255873076 0.0041712294222695 no 61 0.00207216019554797 45 2908540 YHR072W ERG7
SGTC_2937 9044753 11.33 µM 2.86094318427003 0.00424025593647889 no 62 0.00211191369753847 96 6465530 YGL099W LSG1
SGTC_3211 9128781 49.47 µM 2.85819456907259 0.0042721137184 no 63 0.00213029527880447 139 17194361
SGTC_1951 sophoraflavanone G 9.2 µM 2.84826729610743 0.00438896534810957 no 64 0.00219789937022808 93 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1856 st057054 55.7 µM 2.84531490024331 0.00442426402513956 no 65 0.00221837686660987 68 1266018
SGTC_1247 0448-0043 5.84 µM 2.82197644712424 0.00471234244964952 no 66 0.00238643412067025 126 3089013 YGL099W LSG1
SGTC_3170 9103054 49.47 µM 2.81317615452169 0.00482523989321029 no 67 0.00245273850355088 63 16432970
SGTC_642 0335-0876 158 µM 2.7890831249011 0.00514675948622687 no 68 0.00264287481913315 95 6812350
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 2.77006995135143 0.00541380693324306 no 69 0.00280221274566588 86 688664
SGTC_573 3702-0553 84.7 µM 2.76836017615634 0.0054384146342261 no 70 0.00281695773649636 61 1222756
SGTC_3243 9134147 49.47 µM 2.76594810169414 0.00547329912259975 no 71 0.00283787834017411 27 24282180
SGTC_1111 tnp00062 510.699 nM 2.76034736623109 0.00555506741625838 no 72 0.00288699658936493 58 676306
SGTC_1347 1493-0251 600 nM 2.74172789676999 0.00583475834387037 no 73 0.00305584737079262 78 3986378
SGTC_2572 astragaloside iv 100 µM 2.73935533222331 0.00587128045427345 no 74 0.0030779900196132 102 45006101 An anti-inflammatory agent.
SGTC_1815 st051655 58.2 µM 2.73628650378495 0.00591882120692997 no 75 0.00310684502508431 45 5984156
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 2.72580326896133 0.00608380727506419 no 76 0.00320726092213975 71 689007
SGTC_593 1203-0218 61.7 µM 2.70633752692455 0.00640099953661155 no 77 0.00340149311656172 71 3666956
SGTC_1740 st038286 13.222 µM 2.70166116442533 0.00647934691717546 no 78 0.00344970168771715 106 716786
SGTC_752 1896-0090 130 µM 2.70115502231943 0.00648787744871875 no 79 0.00345495614205462 69 772567
SGTC_155 k072-0202 43.6 µM 2.69308316570186 0.00662526966054217 no 80 0.00353973037126346 76 5857737
SGTC_429 1112-0049 25.5 µM 2.68584053662731 0.0067507303881059 no 81 0.00361738041533924 120 2836170
SGTC_3222 9128301 49.47 µM 2.6839754069452 0.00678337717368331 no 82 0.00363762288432726 94 4911358
SGTC_1602 st001878 87.6 µM 2.68165683732594 0.00682415528379728 no 83 0.0036629282742501 81 595405 YLR310C CDC25
SGTC_1920 st075728 45.7 µM 2.64579691758262 0.00748299466206897 no 84 0.00407493640758208 110 3400306
SGTC_1842 st055362 61.2 µM 2.64218847830587 0.0075522973078857 no 85 0.00411861013194457 92 676032
SGTC_738 1315-0003 72.4 µM 2.64175985744673 0.00756056672146136 no 86 0.0041238255565785 100 6251474
SGTC_2944 9067346 25.62 µM 2.63653101780701 0.00766209095709219 no 87 0.00418792711063958 113 6473075
SGTC_2072 5231554 129 µM 2.62965581684707 0.00779740668374601 no 88 0.00427356765608012 65 789545
SGTC_1125 tnp00248 1.32998 µM 2.61915741193961 0.00800809057342079 no 89 0.00440736309739384 155 24207736
SGTC_1266 0828-0227 32.9 µM 2.60461585384501 0.00830817391230221 no 90 0.00459886596331836 103 3913820
SGTC_594 1487-1584 10.8 µM 2.59300728290387 0.00855477464571601 no 91 0.00475703779246406 95 5013332
SGTC_1479 0549-0158 134 µM 2.5920735169745 0.00857488686623938 no 92 0.00476996914262152 119 5440202
SGTC_2850 9015429 58.44 µM 2.59160940813142 0.00858489864872353 no 93 0.00477640805432005 95 6457570
SGTC_1 0258-0098 57.368 µM 2.5894289364852 0.00863207329436457 no 94 0.00480676314667053 68 6790032 YDR047W HEM12
SGTC_1017 4239-0030 168 µM 2.57799646902883 0.00888315511667908 no 95 0.00496875067046554 130 1149593
SGTC_639 0833-0042 114 µM 2.57623599931101 0.00892238215014545 no 96 0.00499412236313342 136 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_2696 st077691 74.316 µM 2.57572971810156 0.00893369124219419 no 97 0.00500144016467944 124 757133
SGTC_1819 st053448 58.6 µM 2.53912637347221 0.00978532154477796 no 98 0.00555648367908162 113 2857616
SGTC_1488 4013-0813 75.9 µM 2.5253525571479 0.01012369132075 no 99 0.00577911354435535 62 2910057
SGTC_524 r073-0010 27.8 µM 2.52078663903258 0.0102380894159165 no 100 0.00585464135360101 148 2772106
SGTC_1549 4'-methoxyflavonol 74.6 µM 2.49251505647222 0.010971843150034 no 101 0.00634209763046791 85 97141
SGTC_1485 3909-9022 254 µM 2.48814384932114 0.0110892834490129 no 102 0.00642058908049671 90 714516
SGTC_305 1682-2595 20.8 µM 2.46530337567225 0.0117208780846327 no 103 0.00684486438053572 121 226033
SGTC_2012 4023501 200 µM 2.44803731606358 0.012218830022951 no 104 0.00718183892685419 128 3477460
SGTC_1774 st048371 48.465 µM 2.44688617754288 0.0122526711761684 no 105 0.00720481685227828 142 4242727
SGTC_1790 st045711 43.5 µM 2.44507151556175 0.0123061835070217 no 106 0.00724117107569109 103 585119
SGTC_1994 st072947 40.9 µM 2.43146249808755 0.0127139898801225 no 107 0.00751900249671294 126 5286565 YDL195W SEC31
SGTC_2417 cerulenin 830 nM 2.42980609677932 0.0127644148929111 no 108 0.00755345126094319 115 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2666 tannic acid 100 µM 2.41388921064559 0.0132578493675165 no 109 0.00789163036255271 158 16134267 A thiamine antagonist.
SGTC_769 0302-0231 76 µM 2.40423255421433 0.0135651743685572 no 110 0.00810322994046864 200 571869 YER009W NTF2
SGTC_3280 9140961 49.47 µM 2.39759298988522 0.013780029891223 no 111 0.00825159573006541 97 4901226
SGTC_2338 7999974 200 µM 2.37295222653035 0.0146032573814532 no 112 0.00882327309694396 134 315925
SGTC_2575 plumbagin 510 nM 2.367337298591 0.0147966598749436 no 113 0.00895829789736359 167 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2587 piperic acid 92.2 µM 2.35993330025207 0.0150550502408534 no 114 0.00913911055933779 137 5370536
SGTC_2016 5121758 140 µM 2.34541188778163 0.0155731054644246 no 115 0.00950303516046886 197 2795203
SGTC_3272 9137413 49.47 µM 2.34082732871514 0.0157398063829868 no 116 0.00962053181501216 127 17614870
SGTC_2595 hexamethylquercetagetin 100 µM 2.31759103114927 0.0166084429478645 no 117 0.0102357790522376 144 386331
SGTC_2138 5575593 77.673 µM 2.3114636816307 0.0168442220915458 no 118 0.0104036284940144 100 762213
SGTC_1041 0206-0046 107 µM 2.30608945116038 0.0170533721095422 no 119 0.0105528173116064 144 50494
SGTC_2929 9013348 24.6 µM 2.29735883535888 0.017397874940417 no 120 0.0107991540083129 159 2995952
SGTC_1185 1319-0113 81.3 µM 2.28990921319672 0.0176965131653267 no 121 0.0110132900226471 114 4672763
SGTC_42 0133-0086 60.653 µM 2.28201280408795 0.018017826757616 no 122 0.0112442921617171 139 162923 Model of phenazepam hydroxylation.
SGTC_229 benomyl 22.8748 µM 2.26037414385547 0.0189239265248603 no 123 0.0118990199193503 164 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_1307 1187-1599 12.2 µM 2.22181799099184 0.0206345794724915 no 124 0.0131478041889005 156 1538471
SGTC_1925 st057770 10.1 µM 2.21446218159052 0.0209753981832804 no 125 0.0133985007425726 157 5989122
SGTC_1425 4048-4433 7.33 µM 2.19777261678643 0.0217663813716156 no 126 0.0139826568747582 191 23734946
SGTC_2785 7756463 72.73 µM 2.19107088101469 0.022091018437836 no 127 0.0142233317706815 167 2201551
SGTC_1442 4112-3290 3 µM 2.18990542670374 0.0221478890146666 no 128 0.0142655481703004 172 704353
SGTC_2676 harmalol 100 µM 2.18791320142461 0.0222453895860744 no 129 0.0143379627477321 147 5459187 A monoamine oxidase inhibitor
SGTC_1628 st004252 77.7 µM 2.17973736388476 0.0226493205498081 no 130 0.0146384676217778 187 692968
SGTC_2189 6047310 154.431 µM 2.17849827898043 0.0227110743425952 no 131 0.0146844801113713 144 711535
SGTC_154 3389-1638 511.116 µM 2.17803342566405 0.0227342783833411 no 132 0.0147017741585053 178 5238686
SGTC_522 1273-0010 11.6 µM 2.17662955044948 0.0228044768142802 no 133 0.0147541092583796 176 5705015
SGTC_2719 novobiocin 32.65 µM 2.17396444786621 0.0229382433435617 no 134 0.0148539026417893 83 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1360 1598-0022 39.8 µM 2.16667787541328 0.0233073481924175 no 135 0.0151297123723391 241 761525
SGTC_424 splitomicin 100 mM 2.1598140973736 0.0236595958464862 no 136 0.0153935319350116 173 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1889 st059080 5.18 µM 2.14460314238486 0.0244561954942086 no 137 0.0159922954251768 189 176925 Isolated from Daphnopsis sellowiana.
SGTC_1421 4029-0249 71.4 µM 2.12925232130866 0.0252828243718086 no 138 0.0166166950952447 200 2894095
SGTC_2198 6589944 200 µM 2.12763607120347 0.0253712045238632 no 139 0.0166836345464826 135 5290268
SGTC_504 lovastatin 124 µM 2.12753491755254 0.0253767444252138 no 140 0.0166878316393346 130 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2222 6885208 172.143 µM 2.12749396686135 0.0253789874676778 no 141 0.016689531032635 98 609514
SGTC_162 k030-0015 37.8 µM 2.11177198202093 0.0262525041690681 no 142 0.0173530057754702 159 1809920 YMR134W ERG29
SGTC_1596 piperlongumine 63 µM 2.10452444009551 0.0266635645839669 no 143 0.0176663624918938 179 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1648 st011736 69.8 µM 2.10190834492738 0.0268132566825874 no 144 0.0177806527044113 163 2855514
SGTC_1909 st060837 51.5 µM 2.09658678204895 0.0271199207727291 no 145 0.0180150851888635 226 678937
SGTC_1045 1348-1485 165 µM 2.0861086517582 0.0277322981137651 no 146 0.0184843910906027 260 6810614
SGTC_1164 k060-0068 93.7 µM 2.08519803996224 0.0277860572867933 no 147 0.0185256638754353 218 5963676
SGTC_616 4092-0450 108 µM 2.0692422623268 0.0287422045168628 no 148 0.0192616793383025 224 787165
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 2.06906018005567 0.0287532716882435 no 149 0.0192702198993955 178 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2291 7917025 104.35 µM 2.06641523860436 0.0289144342397249 no 150 0.0193946441389092 255 2964612
SGTC_2912 7964298 10.93 µM 2.06066046558427 0.0292676811214051 no 151 0.0196677219041885 304 2975850
SGTC_129 0088-0017 176.636 µM 2.05753137472225 0.0294612545567199 no 152 0.0198175700719122 250 182446
SGTC_541 4513-1321 94 µM 2.05722319306654 0.0294803768136024 no 153 0.019832380776997 203 747515
SGTC_1065 prochlorperazine maleate 2.48 µM 2.04732841129557 0.0300998323616586 no 154 0.0203129250619165 217 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_6 0844-0013 19.835 µM 2.03734340169098 0.0307358374275953 no 155 0.0208078206813208 437 1584900
SGTC_1857 st056007 79.3 µM 2.02644479917209 0.0314426939340612 no 156 0.0213596120301389 158 619834
SGTC_3158 9100007 49.47 µM 2.02273065152465 0.0316866337317111 no 157 0.0215504624567732 170 19297233
SGTC_2895 9054447 58.44 µM 2.0226754252703 0.0316902726774384 no 158 0.0215533110809676 156 2697450
SGTC_2067 5224629 34.075 µM 2.01673491382825 0.0320837235428039 no 159 0.0218615921777082 232 2835000
SGTC_2482 5981709 142.65 µM 2.01207763831087 0.0323949962164723 no 160 0.0221058767464376 254 877755
SGTC_79 0052-0007 94.094 µM 2.00876970009494 0.0326175949246715 no 161 0.0222807815012625 219 2801472
SGTC_1198 1612-1005 86.7 µM 2.0061762713837 0.0327929935224369 no 162 0.0224187222902296 191 6998509
SGTC_2429 5902844 64.44 µM 2.00414755052044 0.0329307412504277 no 163 0.0225271285242806 254 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_2453 5731132 22.18 µM 2.00366550324619 0.0329635417095697 no 164 0.0225529519744483 224 1362040
SGTC_2904 7225135 42.03 µM 2.0008909319119 0.033152858717498 no 165 0.0227020725099221 183 4446116
SGTC_2830 7992007 71.43 µM 1.99403101598896 0.033624777966298 no 166 0.0230743325425297 209 1952075
SGTC_2892 9047358 58.44 µM 1.9928942871495 0.0337035092160396 no 167 0.0231365120157592 158 6466771
SGTC_2691 st077356 60.2 µM 1.99200121881811 0.0337654705883125 no 168 0.0231854620778859 237 2839272
SGTC_288 1315-0019 35.1 µM 1.98665622666184 0.034138269753172 no 169 0.0234802528800704 234 6811474
SGTC_2011 4012611 177 µM 1.98552945192335 0.0342172896535591 no 170 0.023542798352831 234 2049887
SGTC_128 0906-2981 13.371 µM 1.9817050982189 0.0344866107207078 no 171 0.0237561281419575 179 6740226
SGTC_1380 2291-0730 164 µM 1.97545657048561 0.0349303941717969 no 172 0.0241081792301341 222 2999191
SGTC_1217 1183-1422 255 µM 1.96261784950754 0.0358569411817402 no 173 0.0248452975481831 230 2849664
SGTC_2528 xanthyletin 44.79 µM 1.95243369269129 0.0366061519129338 no 174 0.0254433680667707 211 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_2564 betulinic acid 100 µM 1.9467938126852 0.0370265364971641 no 175 0.0257797295267493 283 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1475 4092-1048 11.7 µM 1.94019204996824 0.0375236221276468 no 176 0.0261781771654637 273 2881759
SGTC_409 arachidonic acid 100 µM 1.94014542977667 0.0375271517187678 no 177 0.0261810091220335 222 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2343 7990716 14.84 µM 1.93980565671926 0.0375528839539463 no 178 0.0262016564691543 225 6456862
SGTC_482 fipronil 114 µM 1.93946983756863 0.0375783309006746 no 179 0.0262220769213572 138 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_172 1112-0046 2.638 µM 1.93886384439148 0.0376242861116827 no 180 0.0262589597545485 208 2802135 YIL048W NEO1
SGTC_2731 amoxapine 43.43 µM 1.93279252813912 0.0380872387878262 no 181 0.0266308805846012 98 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_3087 9117406 49.47 µM 1.93093807560328 0.0382295681418705 no 182 0.0267453554048767 217 42546093
SGTC_3026 9090633 49.47 µM 1.93029211578638 0.0382792473346535 no 183 0.0267853266965895 237 25236842
SGTC_45 0kpi-0036 14.9 µM 1.91991304084989 0.0390847188224928 no 184 0.0274344422032418 227 2795021
SGTC_1591 genipin 88.4 µM 1.91743243847677 0.0392792558046193 no 185 0.0275915082371946 208 442424 A DNA cross-linking agent.
SGTC_1036 k216-0215 33.5 µM 1.91472638694127 0.0394923711201409 no 186 0.0277637033098334 301 622330
SGTC_636 0kpi-0074 126 µM 1.91068832075549 0.0398121374268056 no 187 0.0280223232966065 222 616434
SGTC_101 0490-5701 117.494 µM 1.90955309435592 0.0399024117720873 no 188 0.0280953896830557 196 4661669
SGTC_1331 1472-0049 76.2 µM 1.90909167010828 0.0399391522164587 no 189 0.0281251335633755 261 24051409
SGTC_2314 7727897 200 µM 1.9082623471744 0.0400052553375814 no 190 0.028178658476236 231 900724
SGTC_2122 5258151 111.688 µM 1.90741819022669 0.0400726321167833 no 191 0.0282332278461121 263 2173356
SGTC_1092 toremifene 6.32 µM 1.90557247077849 0.0402202702743092 no 192 0.0283528483236169 293 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1859 st055998 20 µM 1.90303881701642 0.0404236551684726 no 193 0.0285177401879265 249 676301
SGTC_2950 9072895 21.46 µM 1.89538681404286 0.0410429812393345 no 194 0.0290205871567838 323 17332245
SGTC_1922 5578187 25 µM 1.88821995463713 0.041629998993887 no 195 0.0294982140084052 279 1350412
SGTC_3000 9075062 71.4286 µM 1.88754832857606 0.041685356836881 no 196 0.0295433062397574 240 17057871
SGTC_1100 amiodarone 5.07 µM 1.88398009131096 0.0419804644892862 no 197 0.0297838342344078 275 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_230 MPP+ 141.667 µM 1.88308902151033 0.0420544228669813 no 198 0.029844152387368 243 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 1.88295055512815 0.04206592497378 no 199 0.0298535345216772 325 91467 include heat shock
SGTC_3306 9127676 59.7925 µM 1.87229405905261 0.0429588041308375 no 200 0.0305829661195015 261 41905287
SGTC_2534 helenine 20.12 µM 1.86936843042942 0.0432065957903938 no 201 0.0307857867988573 209 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1435 4092-0789 56.7 µM 1.86510591724191 0.043569682181103 no 202 0.0310832796613234 238 2248285
SGTC_481 bay k-8644 50 µM 1.86007729242003 0.0440011888816386 no 203 0.0314372956775637 254 2303 A calcium channel antagonist.
SGTC_3248 9135562 49.47 µM 1.85811453912333 0.0441705452015866 no 204 0.0315763752953189 255 17650701
SGTC_1718 roemerine 11.9335 µM 1.85536763824404 0.044408443657871 no 205 0.0317718726998447 333 235224 An aporphine alkaloid with mutagenic activity.
SGTC_1879 gemcitabine 100 µM 1.85534835564327 0.044410117291327 no 206 0.0317732485722313 249 60750 A nucleoside analog which inhibits DNA replication.
SGTC_1507 4075-3230 155 µM 1.85471492392196 0.0444651242650987 no 207 0.0318184732329497 193 659771
SGTC_2081 5214970 32.255 µM 1.85323888088363 0.0445935162974248 no 208 0.0319240635501849 250 2063512
SGTC_1697 st025554 27.742 µM 1.85306635313379 0.0446085429128138 no 209 0.0319364243758482 227 1269519
SGTC_1345 1488-0192 31.4 µM 1.85160752470449 0.0447357653130215 no 210 0.0320411008674476 260 658348
SGTC_3227 9130768 49.47 µM 1.85066466681932 0.0448181459737396 no 211 0.0321089051054517 195 17720899
SGTC_918 glabranin 770.725 nM 1.84936433620146 0.044931960571542 no 212 0.0322026107700564 288 124049 Also referred to as licorice root.
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.84549390412498 0.0452721069980865 no 213 0.0324828622165493 307 5379071
SGTC_909 3448-9333 149 µM 1.83751191055625 0.0459801318026947 no 214 0.0330671799011826 247 3344074
SGTC_2858 9025781 8.96 µM 1.83693739578913 0.0460314341395805 no 215 0.0331095689517524 402 4894980 YPL153C RAD53
SGTC_557 1315-0110 16.2 µM 1.83559644396602 0.0461513557861802 no 216 0.0332086817423436 273 6833801
SGTC_2388 9080168 200 µM 1.83427672596702 0.0462696233515184 no 217 0.0333064635807843 209 15943073
SGTC_1883 5-benzylidenerhodanine 20 µM 1.83218439642504 0.046457627753361 no 218 0.0334619763880072 366 1273210
SGTC_1419 3993-2473 62.6 µM 1.82992597378583 0.0466612439117425 no 219 0.0336305044578783 256 704026
SGTC_873 0591-4978 488 µM 1.82874192652095 0.0467682816905365 no 220 0.033719139207406 280 3305145
SGTC_209 4077-0173 175.592 µM 1.82828153154255 0.0468099545085553 no 221 0.0337536550590221 178 15993494
SGTC_1927 st060202 13.8 µM 1.82747055454304 0.0468834328250418 no 222 0.0338145247770206 252 688887
SGTC_270 tamoxifen 5.46 µM 1.82142752178201 0.0474338770278781 no 223 0.0342709473799874 300 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_487 nimodipine 119 µM 1.81994386672319 0.0475698079884827 no 224 0.0343837768356851 175 4497 L-type voltage-gated calcium channels inhibitor
SGTC_32 0928-0142 34.1 µM 1.80986224705694 0.0485017582484141 no 225 0.0351585759885073 223 2244242
SGTC_2755 lomerizine 42.69 µM 1.80705279655604 0.0487640501960373 no 226 0.0353770237922112 292 3949 A calcium channel blocker.
SGTC_2778 tioconazole 65.09 nM 1.80145219761871 0.049290307416644 no 227 0.0358158176374056 354 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3129 9127257 49.47 µM 1.79090512726807 0.0502936611254455 no 228 0.0366542603857074 264 837894
SGTC_342 k048-0088 23.3 µM 1.77781223135413 0.0515617729885661 no 229 0.0377173494737199 294 6820570
SGTC_782 0083-0095 30.5 µM 1.77575253430204 0.0517635593996185 no 230 0.0378868571509157 346 3591729 An indicator and reagent.
SGTC_2287 7945887 168.79 µM 1.77535877042977 0.0518022074171873 no 231 0.0379193335604101 274 1245853
SGTC_215 1287-0124 461.5 µM 1.77185561584982 0.0521470533226786 no 232 0.0382092638392504 195 5560863
SGTC_907 3448-6986 75.5 µM 1.76642049114988 0.0526856861042287 no 233 0.0386626649125626 332 590582
SGTC_344 k064-0035 6.43 µM 1.76617135581998 0.0527104813873341 no 234 0.038683552541566 291 5088750
SGTC_2990 9074105 71.4286 µM 1.76277956848002 0.0530489721620423 no 235 0.0389688373336833 251 6502001
SGTC_684 1140-0066 328 µM 1.76106763449449 0.0532204716758295 no 236 0.0391134781197304 347 6813534
SGTC_366 0181-0206 4.31 µM 1.75473105481017 0.0538590897795556 no 237 0.0396526607421624 358 274874
SGTC_181 1447-1644 8.07 µM 1.74902636633254 0.0544392004943986 no 238 0.0401432309577445 307 534600
SGTC_1318 1280-3875 124 µM 1.74794462882912 0.054549757970948 no 239 0.0402368079577006 347 373245
SGTC_3239 9133757 49.47 µM 1.73062110865029 0.056344582884458 no 240 0.0417596821512407 239 17036923
SGTC_2062 5245942 200 µM 1.72735927638391 0.0566876793445929 no 241 0.0420515797837468 341 1376160
SGTC_189 3970-0742 2.116 µM 1.72612885839458 0.0568175278020845 no 242 0.0421621165590796 251 2891807
SGTC_316 k060-0003 58.6 µM 1.72590318330133 0.0568413691463691 no 243 0.0421824159756096 292 6152314
SGTC_405 ebelactone b 50 µM 1.72400890957043 0.0570417995925361 no 244 0.0423531173821617 322 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_1177 0983-0204 23.6 µM 1.72264187415767 0.0571867890351028 no 245 0.0424766538203866 319 766818
SGTC_2427 5545055 42.75 µM 1.72132861169096 0.057326348273099 no 246 0.042595605192561 335 5372858
SGTC_2756 carbadox 75.1 µM 1.7210922303628 0.057351496743599 no 247 0.0426170444802662 380 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_789 1309-1135 70.6 µM 1.72073953341801 0.0573890361019343 no 248 0.0426490495690785 348 3092424
SGTC_2923 7992654 58.14 µM 1.72048719571923 0.0574159055685783 no 249 0.0426719595934845 328 2985126
SGTC_2228 7354201 200 µM 1.72024131051051 0.0574420974801013 no 250 0.0426942933590864 255 753451
SGTC_1190 1486-1332 13 µM 1.71968117408964 0.0575017988067031 no 251 0.0427452058613611 294 4150046
SGTC_985 1493-0307 8.71 µM 1.71721703212772 0.0577650156487065 no 252 0.0429697623372089 253 3278274
SGTC_2365 9042475 200 µM 1.71293623142655 0.0582245373044595 no 253 0.0433621359083452 339 6464479
SGTC_2446 5162541 200 µM 1.71180687417088 0.0583462454265937 no 254 0.043466132419464 301 1549321
SGTC_1354 1498-1681 81 µM 1.71090870835685 0.058443181177674 no 255 0.0435489833923189 332 5754243
SGTC_2091 4-phenylthiadiazole 200 µM 1.70607377254217 0.0589671726148994 no 256 0.0439971725226286 336 270010
SGTC_1448 4255-0083 152 µM 1.70364319548218 0.0592319776234841 no 257 0.0442238832083222 302 5399660
SGTC_3121 9125696 49.47 µM 1.70189673468662 0.0594228250438019 no 258 0.0443873640075874 245 1235365
SGTC_3023 9089636 49.47 µM 1.70128995066502 0.0594892451004306 no 259 0.0444442770458791 299 17249241
SGTC_2657 nystatin 74.44 µM 1.69821435368848 0.0598268028461093 no 260 0.0447336562121092 320 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2266 7929956 200 µM 1.68998927916528 0.0607369075010907 no 261 0.0455150028515416 362 2967153
SGTC_1621 st003705 32.4 µM 1.68463683094839 0.061334947885698 no 262 0.0460293304145253 366 24207032
SGTC_191 3914-0123 66.505 µM 1.68365378057489 0.0614452845689934 no 263 0.0461242992888062 201 3144412
SGTC_3115 9123671 49.47 µM 1.68054975181295 0.0617946957789026 no 264 0.0464252014519986 278 3286988
SGTC_3276 9139060 49.47 µM 1.67935051856397 0.0619301045101164 no 265 0.0465418753702116 247 4870619
SGTC_2972 9093619 59.92 µM 1.67751727578595 0.062137548428597 no 266 0.0467206870591869 325 25236256
SGTC_2033 5192550 145 µM 1.66772931148996 0.06325431016189 no 267 0.0476847369800207 309 182073
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 1.66074396011979 0.0640608175120629 no 268 0.0483824402158305 608 16725076
SGTC_1787 fluconazole 80 µM 1.64820765799275 0.0655282427324263 no 269 0.0496550329559889 437 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_947 3447-0010 211 µM 1.64253565113668 0.0662006801120912 no 270 0.050239522032116 326 748350
SGTC_3257 9139206 32.98 µM 1.64206001848534 0.0662573101201256 no 271 0.0502887832053247 255 4910041
SGTC_2497 7-hydroxyflavone 100 µM 1.64169095135724 0.0663012780165186 no 272 0.0503270339285867 326 5281894
SGTC_488 nitrendipine 139 µM 1.63871703054927 0.0666563937055068 no 273 0.050636102764566 360 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1135 dihydrocapsaicin 536.708 nM 1.63847905661783 0.0666848736447439 no 274 0.0506608997188003 373 107982 A Capsaicinoid.
SGTC_974 1326-0144 138 µM 1.63753130093471 0.0667983913778671 no 275 0.0507597521157574 396 5411856
SGTC_2283 7944793 200 µM 1.63584362617061 0.0670009032555891 no 276 0.0509361594501049 371 2970533
SGTC_1624 st003710 6.25 µM 1.63300507422811 0.0673425847959356 no 277 0.0512339647364337 416 24207033
SGTC_2371 9071574 200 µM 1.63248762360997 0.0674050161390069 no 278 0.0512884018013443 287 45596039
SGTC_3141 9094609 49.47 µM 1.63045120941919 0.0676511476830299 no 279 0.0515030845425392 362 25236309 YDL196W YDL196W
SGTC_1992 st073643 23.3 µM 1.62179653740454 0.0687049489304514 no 280 0.0524234600472743 331 3161292
SGTC_297 0986-0032 24 µM 1.62053827925096 0.0688592039274921 no 281 0.0525583491955196 309 2847425
SGTC_2686 alizarin 95.37 µM 1.60913637737118 0.0702692059492547 no 282 0.0537932622296543 343 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_2005 4024620 188 µM 1.60561024908978 0.0707097255652897 no 283 0.0541797860693315 337 236743
SGTC_3055 9094636 49.47 µM 1.60210091214212 0.0711502513935068 no 284 0.0545666481724009 326 25236176
SGTC_2838 9002687 71.43 µM 1.60151014895819 0.0712246164789319 no 285 0.0546319869856824 344 6457060
SGTC_2714 st079313 56.9 µM 1.59924394213594 0.0715104394924386 no 286 0.0548832050053322 353 2939799
SGTC_1590 st077108 57.8 µM 1.59494370469848 0.072055221154159 no 287 0.0553624125732006 327 5489485
SGTC_1837 st055472 66.5 µM 1.59442785491162 0.0721207854723214 no 288 0.0554201188371406 369 676091
SGTC_2512 diallyl trisulfide 49.23 µM 1.59246804352926 0.0723702937387079 no 289 0.0556397889741146 301 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_966 1300-0360 30.2 µM 1.59239854147417 0.0723791543395949 no 290 0.0556475918774995 375 70588
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.59190784574356 0.072441735264494 no 291 0.0557027062115639 467 551469
SGTC_980 1473-0395 201 µM 1.59061447359387 0.0726068842282043 no 292 0.0558481825848621 313 768876
SGTC_2947 9072639 7.68 µM 1.59051669968565 0.072619380561819 no 293 0.0558591922086382 426 16488146
SGTC_852 0418-0143 439 µM 1.58812025638712 0.072926181533124 no 294 0.0561295743178508 458 5369229
SGTC_526 4469-0568 170 µM 1.58798266384837 0.0729438266790108 no 295 0.0561451296650032 374 2901964
SGTC_1393 3470-5649 58.2 µM 1.58001973546016 0.0739705860424514 no 296 0.0570511734680634 299 4108395
SGTC_531 3788-1495 174 µM 1.57531072777231 0.0745829519990721 no 297 0.0575923694835376 385 2896655
SGTC_3092 9117248 49.47 µM 1.57468444904778 0.0746646848395203 no 298 0.0576646495444258 325 17141857
SGTC_2549 cedrol 20.94 µM 1.57382084772071 0.0747775016851466 no 299 0.0577644364579355 316 6708665 A sedative which affects the nervous system.
SGTC_1713 st033146 12.748 µM 1.57267773651825 0.0749270323576049 no 300 0.0578967287526735 387 674619
SGTC_3171 9103192 49.47 µM 1.571644886699 0.0750623357592244 no 301 0.0580164651949264 319 13018434
SGTC_960 1222-0186 7.7 µM 1.56764213114125 0.0755884578030782 no 302 0.0584823369366136 394 3126296
SGTC_2247 cerulenin 830 nM 1.5636071045702 0.0761216606134605 no 303 0.0589549326975615 401 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2465 5809242 33.21 µM 1.56160902499362 0.0763867516166424 no 304 0.0591900610418802 310 2731748
SGTC_1603 st002045 67.8 µM 1.56138509622033 0.0764165046126977 no 305 0.0592164581103064 375 5887985
SGTC_649 1123-0311 367 µM 1.56126501534281 0.076432463165021 no 306 0.0592306172311335 450 693629 YIL048W NEO1
SGTC_926 2268-1401 59.4 µM 1.55812020954072 0.0768513060103131 no 307 0.0596023774054169 404 2931578
SGTC_21 0849-0113 22.993 µM 1.55776516852829 0.0768987017680891 no 308 0.0596444628553602 413 1560156
SGTC_1023 4482-3888 16 µM 1.55351188787831 0.0774682169545845 no 309 0.0601504457196737 372 3303168
SGTC_1246 0422-0085 105 µM 1.55158062154181 0.0777278689379375 no 310 0.0603813014448623 438 264295
SGTC_1864 st057645 30.4 µM 1.54942991666674 0.0780178005523513 no 311 0.0606392033651976 334 688666
SGTC_3104 9120930 49.47 µM 1.54141997320392 0.0791048240339299 no 312 0.0616073030186109 340 17014836
SGTC_3290 9121031 71.43 µM 1.53663746079543 0.0797593013947424 no 313 0.0621910568492584 350 17014854
SGTC_2639 lactacystin 53 µM 1.53282469199526 0.0802839990420918 no 314 0.0626595275085239 429 3870 A proteasome inhibitor.
SGTC_724 3910-0327 137 µM 1.5313136992983 0.0804926558863027 no 315 0.0628459407082727 420 2885483
SGTC_2735 sertaconazole 140 nM 1.53031516540197 0.0806307706402759 no 316 0.0629693681181495 305 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2578 7,8-dihydroxyflavone 64.44 µM 1.52912586005486 0.0807955058922372 no 317 0.0631166228263148 408 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_851 0394-0702 453 µM 1.52867440073711 0.0808581057548525 no 318 0.0631725907613421 435 762646
SGTC_1287 0971-0001 34.6 µM 1.52801011624527 0.0809502827678931 no 319 0.0632550131387967 462 4665869
SGTC_2319 6033012 152.6 µM 1.5279542581721 0.0809580373233944 no 320 0.0632619476512626 336 847246
SGTC_509 pifithrin 175 µM 1.52784353999253 0.0809734095478077 no 321 0.0632756945327091 340 4817 A p53 inhibitor.
SGTC_1129 3453-1384 223 µM 1.5229113209223 0.0816604411949905 no 322 0.0638904465363645 450 1084452
SGTC_1032 k061-1018 98.7 µM 1.51855862105657 0.0822703914178671 no 323 0.0644368166813919 488 4005393
SGTC_201 4262-0159 12.803 µM 1.51551139790812 0.0826994408154618 no 324 0.0648214730443887 340 1341029
SGTC_2757 clomiphene 4.22 µM 1.5129382197995 0.0830630541155527 no 325 0.0651476762344658 478 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2943 9068529 45.32 µM 1.512083942252 0.0831840367173432 no 326 0.0652562546633708 448 3270634
SGTC_1386 3228-0095 33.8 µM 1.51139994612228 0.0832809995784669 no 327 0.065343291540008 388 870181
SGTC_1852 st056254 31.4 µM 1.51043764118351 0.0834175591530256 no 328 0.065465894982284 395 442583
SGTC_2644 guaiazulene 100 µM 1.50929836039649 0.0835794506630971 no 329 0.0656112767698524 374 3515 A coloring agent.
SGTC_788 1182-0090 188 µM 1.50869879031669 0.0836647441777125 no 330 0.0656878874121451 544 5715185
SGTC_2767 sibutramine 71.45 µM 1.50801742806491 0.0837617526319687 no 331 0.0657750332928693 409 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2733 amorolfine 100 µM 1.50777153589194 0.0837967820909418 no 332 0.0658065047717766 267 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3274 9138298 49.47 µM 1.50745508560621 0.0838418793523404 no 333 0.0658470240829222 442 17015756
SGTC_2058 5236698 133 µM 1.49923749949817 0.0850193578101938 no 334 0.0669060149893383 426 766665
SGTC_2044 5102272 200 µM 1.48860984720552 0.0865604936966782 no 335 0.0682950685228653 372 592666
SGTC_698 k064-0052 127 µM 1.48256327531636 0.0874465884085143 no 336 0.0690952402395531 347 5088751
SGTC_2075 5212009 200 µM 1.47963869551207 0.0878775923388228 no 337 0.0694848469986348 383 780898
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.47852315793816 0.0880424091482851 no 338 0.0696339016507268 414 6710655
SGTC_1684 st024538 14.6195 µM 1.47557922609744 0.0884784714320365 no 339 0.0700284426686135 429 6732859
SGTC_1486 3970-0793 4.53 µM 1.47268160054379 0.0889092440613199 no 340 0.0704184550732733 425 2844330
SGTC_306 1672-3436 11.6 µM 1.47189739336449 0.0890260954731122 no 341 0.0705242938074587 435 6797378
SGTC_2776 terbinafine 19.92 µM 1.47036543740528 0.0892546954889819 no 342 0.0707314034573449 445 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_508 roscovitine 141 µM 1.46912364285962 0.0894403175943936 no 343 0.0708996280354835 405 160355 A CDKinase inhibitor.
SGTC_1722 st034304 3.6505 µM 1.46676867074015 0.0897931246100677 no 344 0.0712194974847609 454 4036148 YLR033W RSC58
SGTC_2425 5628681 7.85 µM 1.46390348924284 0.0902237616466634 no 345 0.0716101599482904 526 5714958
SGTC_1438 4092-1045 4 µM 1.46303310752976 0.0903548834015226 no 346 0.0717291599656197 441 1351342
SGTC_23 0213-0011 39.996 µM 1.46147205967631 0.0905904074335584 no 347 0.0719429689134067 440 627608
SGTC_3356 9151811 4.48 µM 1.45986826312737 0.0908328555028655 no 348 0.072163141531997 435 1859254 YPR165W RHO1
SGTC_2752 diclazuril 33.15 µM 1.45513981917244 0.0915504625821963 no 349 0.0728152787214008 623 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_1082 camptothecin 424.86 nM 1.45427270062498 0.0916825145033174 no 350 0.0729353579845337 409 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2703 st077852 53.4 µM 1.44881751799374 0.09251651245564 no 351 0.0736942751344454 440 6281836
SGTC_2190 6049624 200 µM 1.44820275566139 0.092610849175537 no 352 0.0737801770748199 377 2265554
SGTC_3258 9138477 49.47 µM 1.44219177780417 0.0935369995406977 no 353 0.0746241397375125 427 4970355
SGTC_1197 1601-0112 267 µM 1.44152642729656 0.0936399333908759 no 354 0.0747180084032021 498 7350313
SGTC_521 r062-0005 13.8 µM 1.44018104101404 0.0938483285053414 no 355 0.0749080928168845 430 2832033
SGTC_1943 st076331 65.2 µM 1.43485938968795 0.094675986986126 no 356 0.0756635850296451 459 24208415
SGTC_1690 st023502 41.2 µM 1.43432644639207 0.0947591692999834 no 357 0.0757395633537798 432 24207482
SGTC_3013 9080133 71.4286 µM 1.43217459889314 0.0950955795537713 no 358 0.0760469296531269 501 17050193
SGTC_237 nikkomycin 200 µM 1.43192494830429 0.0951346656889633 no 359 0.0760826507151752 481 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_304 1310-0298 97 µM 1.43147067476957 0.0952058186297665 no 360 0.0761476828597798 493 1550234
SGTC_3022 9087993 49.47 µM 1.42828081158125 0.0957065514182432 no 361 0.0766055242874522 396 17173644
SGTC_3286 9117135 37.221 µM 1.42732751542444 0.0958565716759115 no 362 0.0767427565393066 464 3438150
SGTC_351 caspofungin 25 nM 1.42681057175501 0.095937995416752 no 363 0.0768172515656537 614 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_392 N-ethylmaleimide 8.33 µM 1.42509298537055 0.096208897518858 no 364 0.0770651620363866 444 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_2244 6635614 200 µM 1.42241473637654 0.0966324391263192 no 365 0.0774529438111101 327 836499
SGTC_2930 9013230 14.89 µM 1.42029589872243 0.0969684838813564 no 366 0.0777607773347627 505 2995857
SGTC_1843 st055809 45.5 µM 1.41982860579048 0.0970427112281215 no 367 0.0778287924116951 444 16413835
SGTC_2988 9073640 71.4286 µM 1.41888147361583 0.097193286763614 no 368 0.0779667871830576 441 9102229
SGTC_2782 7736369 71.43 µM 1.4156892433822 0.0977020517647812 no 369 0.0784332545597034 506 2950836 YOL077C BRX1
SGTC_2725 haloperidol 53.21 µM 1.4149622451756 0.0978181903417704 no 370 0.0785397830025368 473 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_480 am 92016 50 µM 1.413431351312 0.0980630827833194 no 371 0.0787644664116467 413 2129 K+ channel blocker.
SGTC_2270 7924575 90.91 µM 1.41274045407724 0.0981737505135536 no 372 0.0788660261007425 497 1262135
SGTC_2095 5432005 200 µM 1.41215537515001 0.0982675398194315 no 373 0.0789521083892346 424 783734
SGTC_675 1309-0189 238 µM 1.41145448439296 0.0983799803690352 no 374 0.0790553236732928 463 4246530
SGTC_2813 7971799 71.43 µM 1.40659663170965 0.0991618928566682 no 375 0.0797735162233033 446 2234054
SGTC_1165 k072-0275 30.3 µM 1.40354576733496 0.0996552730590564 no 376 0.0802270771180178 459 6153523 YGL055W OLE1
SGTC_2592 piperlongumine 83.33 µM 1.399644520705 0.100288785663298 no 377 0.0808098974930465 446 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_503 tyrphostin 8 294 µM 1.39623019904134 0.100845635520317 no 378 0.0813225927446238 480 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2217 6934799 96.0675 µM 1.39462983146846 0.101107417917133 no 379 0.0815637472234282 455 675606
SGTC_1277 0873-0036 22 µM 1.39139297663519 0.10163840424289 no 380 0.0820531466103548 526 5965735
SGTC_2084 5306078 60.6385 µM 1.39117181678695 0.101674758137098 no 381 0.0820866656575518 486 679340
SGTC_2363 9053361 176 µM 1.39093399327116 0.101713861741095 no 382 0.0821227217642642 503 6469797 YMR079W SEC14
SGTC_2225 6654152 15.4 µM 1.39011464732358 0.101848664719826 no 383 0.0822470330697139 391 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2229 7354935 190 µM 1.38948307672788 0.101952662656125 no 384 0.0823429517517009 405 318112
SGTC_2092 5303694 80.6725 µM 1.38646521308227 0.10245066789743 no 385 0.0828024477177866 516 1963699
SGTC_1672 st016598 6.51 µM 1.38219317044541 0.103158657312112 no 386 0.083456198275955 508 4665860 YNL267W PIK1
SGTC_1221 2958-7315 257 µM 1.37918026879835 0.103660106179743 no 387 0.0839195900203035 493 4562705
SGTC_860 0443-0016 25.1 µM 1.37120265609282 0.104996386980732 no 388 0.0851558952247404 486 5337942
SGTC_2889 9059656 51.95 µM 1.36675323146223 0.105747077611763 no 389 0.0858513332873112 529 3949838
SGTC_2202 7226349 200 µM 1.36175582648787 0.10659483891997 no 390 0.0866374782486277 430 844334
SGTC_908 3448-7491 47.7 µM 1.35683635935402 0.107434159845507 no 391 0.0874166058897348 606 1203031
SGTC_1338 1486-1223 76 µM 1.3567870164835 0.107442602399102 no 392 0.0874244470418452 545 3444526
SGTC_906 1165-0455 526 µM 1.35492848041012 0.107760945770726 no 393 0.0877201723084426 487 3252859
SGTC_556 4058-0063 51.5 µM 1.35273556988616 0.108137436326931 no 394 0.0880700613234978 556 6615692
SGTC_3234 9132280 49.47 µM 1.35124638594165 0.108393646633415 no 395 0.0883082600479043 535 17612295
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.35053252042814 0.108516620138369 no 396 0.0884226147357381 500 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1455 4262-0120 131 µM 1.34720422737854 0.109091290891644 no 397 0.0889572334203836 532 1529587
SGTC_1465 k213-0056 144 µM 1.34566232351311 0.109358259606199 no 398 0.0892057211515639 498 24048857 YMR208W ERG12
SGTC_2511 berberine 10.47 µM 1.34493344769084 0.109484622038047 no 399 0.0893233638041652 491 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2188 6126565 140.678 µM 1.33846165061454 0.110611213858608 no 400 0.0903729967542037 452 874518
SGTC_49 0717-0965 32.132 µM 1.33608923530811 0.111026271172418 no 401 0.090760054028744 535 5889349 YGL099W LSG1
SGTC_2734 clemastine 41.6 µM 1.33579702539134 0.111077470753995 no 402 0.0908078127590033 352 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2893 9048488 25.97 µM 1.33324983983019 0.111524492264956 no 403 0.0912249142637928 493 6467338
SGTC_1439 4092-1168 46 µM 1.3303392927784 0.112036856510577 no 404 0.0917032532652849 520 2886240
SGTC_2654 protoveratrine a 100 µM 1.33029759188652 0.112044209622599 no 405 0.0917101201490615 500 5702278 A heart drug and vasodilator.
SGTC_141 0443-0274 32.331 µM 1.33003124733558 0.11209118225658 no 406 0.0917539880800764 650 1627241
SGTC_1245 0418-0076 17.2 µM 1.32797814903295 0.112453740055362 no 407 0.0920926628126291 559 6790114
SGTC_2051 5263410 176 µM 1.31967057277517 0.113929331568133 no 408 0.0934725145574111 552 227584
SGTC_1777 st045864 34.765 µM 1.31821623806063 0.114189063024332 no 409 0.0937156356184354 535 4691462
SGTC_2076 5212012 200 µM 1.31680913657463 0.114440760166048 no 410 0.0939513047580879 418 604802
SGTC_65 0798-0905 34.986 µM 1.31562177542681 0.114653458010924 no 411 0.0941505105752672 642 3602145
SGTC_1529 apigenin 74 µM 1.31544184752408 0.114685713910031 no 412 0.0941807245852805 571 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_3273 9137859 49.47 µM 1.31534410454016 0.114703239122896 no 413 0.094197140865635 477 2377234
SGTC_681 1642-0006 26.6 µM 1.31514896226977 0.114738233623816 no 414 0.0942299220148262 475 4446530
SGTC_1349 flufenamic acid 69 µM 1.31485771240506 0.114790477049444 no 415 0.0942788635350781 508 3371 A non-steroidal anti-inflammatory.
SGTC_364 0083-0097 67.7 µM 1.31269951612623 0.115178134456991 no 416 0.0946421103665795 531 5207356
SGTC_3110 9122132 49.47 µM 1.31056984361019 0.115561579879025 no 417 0.0950015665669056 540 918317
SGTC_2292 7671323 168.05 µM 1.30758766496535 0.116100041042472 no 418 0.0955066014690542 553 937504
SGTC_3094 9117742 49.47 µM 1.30628432391515 0.116335930226248 no 419 0.0957279430127857 573 17149698
SGTC_1754 st042065 16.137 µM 1.30475498016536 0.11661315655339 no 420 0.0959881467048141 686 1126236 YIL048W NEO1
SGTC_3120 9124077 49.47 µM 1.30279395604165 0.116969319241404 no 421 0.0963225573702514 537 18774327 YGL155W CDC43
SGTC_2506 ethyl hematommate 54.16 µM 1.29806643002716 0.117831103589588 no 422 0.09713225434322 459 3940691 An allergen.
SGTC_3328 9140624 29.0385 µM 1.29709855765512 0.118008090433865 no 423 0.0972986388741391 551 4904392
SGTC_1704 st028805 70.8 µM 1.29507395256531 0.118378921179786 no 424 0.0976473597207548 533 2876101
SGTC_1768 st044301 37.178 µM 1.29477388911311 0.118433951419846 no 425 0.0976991209525744 566 3931349
SGTC_1952 st077036 64.1 µM 1.29452370477075 0.118479847884562 no 426 0.0977422933667447 560 2937007
SGTC_171 k064-0041 9.68 µM 1.29399696539438 0.118576519624111 no 427 0.0978332345037693 456 53325
SGTC_1127 asiatic acid 681.4 nM 1.29349860038715 0.118668035159084 no 428 0.0979193339143531 540 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1153 4055-0057 267 µM 1.28886855919441 0.119520642668677 no 429 0.0987218930875138 560 882706
SGTC_112 phenothiazine 287.218 µM 1.28799349454638 0.119682267417525 no 430 0.0988741138724542 567 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_1692 fluoroquinolonic acid 71 µM 1.28590564671604 0.120068516096902 no 431 0.0992379963877889 526 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_2415 st077333 57.7 µM 1.28568500175303 0.120109386348283 no 432 0.0992765088378688 647 2766255
SGTC_1913 st060213 96.1 µM 1.28371361656627 0.120474982817715 no 433 0.0996210891292712 607 688959
SGTC_1515 3460-0031 42.1 µM 1.28201505363377 0.120790611914495 no 434 0.0999186827693444 480 2876596
SGTC_1417 3966-0327 90.4 µM 1.28021629298365 0.121125493922188 no 435 0.100234538653917 622 651118
SGTC_2610 ononetin 44.17 µM 1.27984713549666 0.121194302046058 no 436 0.100299451414444 583 259632
SGTC_677 0929-0063 136 µM 1.27617398124669 0.121880447743446 no 437 0.100947012007848 487 1539583
SGTC_2982 9019404 25.97 µM 1.27477617245646 0.122142274067684 no 438 0.101194238359797 467 22333232
SGTC_3350 9150499 3.57 µM 1.2738801188471 0.122310323222146 no 439 0.101352952642138 624 4910996 YPR165W RHO1
SGTC_2881 9058953 51.95 µM 1.26755468885255 0.12350123436302 no 440 0.10247851090589 586 17122249
SGTC_1625 st003711 30.1 µM 1.25827134163002 0.125263711005685 no 441 0.104146820900855 558 24207034 YER133W GLC7
SGTC_2261 9010538 184.68 µM 1.25625238932887 0.12564932980972 no 442 0.10451223888458 495 6457250
SGTC_1955 wogonin 32.4 µM 1.25530144732595 0.125831245857338 no 443 0.104684674983974 547 5281703 A flavanone.
SGTC_2214 7179297 48.276 µM 1.25261284030518 0.126346572379728 no 444 0.105173319802104 555 769744
SGTC_1505 k297-0037 20.6 µM 1.2507273871612 0.126708834154093 no 445 0.10551697745941 600 4089396
SGTC_1391 3442-0225 151 µM 1.24823009859834 0.127189763538093 no 446 0.105973402232382 522 5227075
SGTC_725 1497-0963 19 µM 1.24588654040533 0.12764224124224 no 447 0.106403026064349 600 3549977
SGTC_2646 retinol 96.75 µM 1.24093942169233 0.128601067181637 no 448 0.107314064157317 572 445354 A vitamin A analog and teratogen.
SGTC_3028 9087778 49.47 µM 1.23914499398204 0.128950086411317 no 449 0.107645903394426 558 17217395
SGTC_2386 9075165 157.42 µM 1.2364660159014 0.129472373734612 no 450 0.108142695221574 568 16452277
SGTC_864 0469-0573 172 µM 1.23022174129678 0.130695427008954 no 451 0.109307040262912 583 689425
SGTC_579 4491-1009 110 µM 1.22998475477594 0.130742001867134 no 452 0.109351406898357 756 1271041
SGTC_1824 st053723 68.6 µM 1.22950165161104 0.130836981452348 no 453 0.10944188949425 597 675225
SGTC_3295 9122362 53.5725 µM 1.22944802803303 0.130847526954282 no 454 0.109451936213471 564 4730473
SGTC_1652 st011932 78 µM 1.22919193065376 0.13089789863711 no 455 0.109499926826137 578 1551076
SGTC_1066 ketoconazole 628 nM 1.22751037306443 0.131228976333843 no 456 0.109815412738748 635 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_82 0054-0107 293.755 µM 1.2266309295359 0.131402357918925 no 457 0.10998066937635 586 3104697
SGTC_3312 9133330 71.43 µM 1.22526175214282 0.13167260481356 no 458 0.110238307166986 641 17617324
SGTC_1715 st032160 10.2275 µM 1.22225061092032 0.132268289503111 no 459 0.110806435020968 578 5289825
SGTC_3241 9133421 49.47 µM 1.22220600135424 0.132277128416395 no 460 0.110814867482894 554 17018221
SGTC_256 clotrimazole 625 nM 1.22016718962061 0.132681531965092 no 461 0.111200751030961 594 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_397 arbidol 50 µM 1.21922730671057 0.132868246646685 no 462 0.111378965213543 632 131410 A RNA synthesis inhibitor.
SGTC_276 colchicine 750 µM 1.21601378529534 0.133508002795621 no 463 0.111989835357575 630 2833 A microtubule depolymerizer.
SGTC_1005 4092-0690 4.4 µM 1.21359943525017 0.133990049454986 no 464 0.112450361410594 582 1529343
SGTC_2174 5790901 200 µM 1.21146775885838 0.134416650767129 no 465 0.112858092018418 601 786020
SGTC_1216 1165-0504 9.65 µM 1.20989059178983 0.134732880626997 no 466 0.113160438909567 641 6304004
SGTC_823 0417-1665 178 µM 1.20487624792578 0.135741671478275 no 467 0.11412553960381 610 3429856
SGTC_132 0417-1715 25.805 µM 1.20297136373861 0.136126250533711 no 468 0.114493701126121 648 6769098
SGTC_924 2046-0044 21.3 µM 1.20176965202426 0.136369248632872 no 469 0.114726393273142 619 3623589
SGTC_1605 st000082 49.1 µM 1.19780470069218 0.137173105329109 no 470 0.115496528393174 613 1114022
SGTC_2260 7964312 200 µM 1.19623490008758 0.137492260365594 no 471 0.115802452543602 569 231951
SGTC_2428 5615643 7.78 µM 1.19462959741766 0.137819157193132 no 472 0.116115890043981 593 2253075
SGTC_1298 1079-1278 263 µM 1.19454412935555 0.137836576391825 no 473 0.11613259466424 660 2840950
SGTC_3323 9138564 53.9225 µM 1.1930111712604 0.138149262831759 no 474 0.116432498990864 689 43912313 YNL103W MET4
SGTC_1512 0259-0544 12.2 µM 1.19142725051681 0.13847285211822 no 475 0.116742950190798 676 18476
SGTC_431 k089-0097 107 µM 1.18872055991828 0.139027013878574 no 476 0.11727482366478 694 5499420
SGTC_2868 9035608 32.47 µM 1.18775656135225 0.139224744883798 no 477 0.117464666367972 621 6462614
SGTC_931 2812-0076 566 µM 1.18769716389692 0.139236934475848 no 478 0.117476370773394 659 3450959
SGTC_2689 tacrolimus 100 µM 1.18577066075991 0.139632686745857 no 479 0.117856440464298 600 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_53 0973-0023 39.979 µM 1.18073443976192 0.140670863962032 no 480 0.118854117755586 614 674768
SGTC_2328 6201408 200 µM 1.17984626865527 0.140854495420056 no 481 0.11903068172289 619 2890418
SGTC_676 falcarinol 140 µM 1.17962724778961 0.140899803482741 no 482 0.11907425042541 657 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1118 chelidonine 707.474 nM 1.17944372561132 0.14093777567109 no 483 0.119110766224107 692 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1600 coumarin 106 71.1 µM 1.17859978202173 0.141112483618949 no 484 0.119278789242752 674 100336 A hepatotoxic, DNA x-linker.
SGTC_1242 0402-0103 60.1 µM 1.17737401367158 0.141366496002188 no 485 0.119523128602169 596 432868
SGTC_319 1348-1596 45.5 µM 1.17631409204258 0.141586390157836 no 486 0.119734693283137 672 5380505
SGTC_2553 4-methylesculetin 85.09 µM 1.17378146573899 0.142112753523096 no 487 0.120241284821776 648 5319502
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.17334650856308 0.142203285075953 no 488 0.120328439359089 709 688761
SGTC_228 caffeine 993.056 µM 1.17088151012764 0.142717084627363 no 489 0.120823204104479 596 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_2173 5763948 167 µM 1.16909346738302 0.143090565270935 no 490 0.121182987803869 662 2867177
SGTC_2803 7707263 71.43 µM 1.16744940140869 0.143434554698835 no 491 0.121514465372431 614 2199229
SGTC_3221 9128209 49.47 µM 1.16672206710503 0.143586913510573 no 492 0.121661314120303 602 16460723
SGTC_3203 9113543 49.47 µM 1.1640348023161 0.144150777086685 no 493 0.122204954126622 617 17018012
SGTC_1042 0350-0096 82 µM 1.16226602668525 0.144522729527455 no 494 0.122563710998393 626 3122515
SGTC_2694 st077685 81.9 µM 1.1620156225944 0.144575438729968 no 495 0.122614559558007 638 2838096
SGTC_1665 st014639 11.4 µM 1.16155974390932 0.144671432878224 no 496 0.122707171017996 700 981133 YIL048W NEO1
SGTC_3033 9090887 49.47 µM 1.16142100799654 0.144700654949251 no 497 0.12273536486431 671 19325384
SGTC_2980 9014342 25.29 µM 1.16001661894857 0.144996686493666 no 498 0.123021019941521 620 2996599
SGTC_2761 levamisole 97.89 µM 1.15506461656568 0.146043771828604 no 499 0.124031983293187 633 26879 An alkaline phosphatase inhibitor.
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 1.15056520341571 0.146999552905708 no 500 0.124955577580377 643 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1490 4089-0339 670 nM 1.14875476763065 0.147385312854535 no 501 0.125328557778498 627 742542
SGTC_134 0269-0018 6.916 µM 1.1476116482107 0.147629232953287 no 502 0.125564459499624 671 4378915
SGTC_1899 st063254 59.6 µM 1.14414730398904 0.148370109222814 no 503 0.126281276352289 592 3093813
SGTC_227 fluconazole 33.516 µM 1.14408783391103 0.148382849023474 no 504 0.126293606314551 700 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_741 4582-0002 126 µM 1.14350578802535 0.148507574694898 no 505 0.126414326479973 661 2912688
SGTC_3252 9135871 49.47 µM 1.14142672430463 0.148953666205929 no 506 0.126846194436621 662 17682838
SGTC_266 formosanin C 406 nM 1.14096818476399 0.149052172500376 no 507 0.126941581425233 686 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2822 7994718 71.43 µM 1.14075596573765 0.149097777428544 no 508 0.126985744861565 574 1018011
SGTC_3046 9092212 49.47 µM 1.13733397633322 0.14983443453815 no 509 0.127699348191063 664 25236637
SGTC_720 r052-1644 49.9 µM 1.13681055366013 0.149947326265518 no 510 0.127808745261399 595 1422863 YOR257W CDC31
SGTC_2357 9067248 200 µM 1.13412447676002 0.150527551162763 no 511 0.128371168871931 624 9150235
SGTC_2779 methotrexate 400 µM 1.13307181289591 0.150755346561228 no 512 0.128592048602274 703 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2934 9036370 36.88 µM 1.13261467780013 0.150854341577101 no 513 0.128688051033997 709 6462800
SGTC_2144 5628481 200 µM 1.12814687891336 0.151824144895996 no 514 0.129628946921353 636 2818399
SGTC_1348 1493-0373 93.8 µM 1.12736269069331 0.151994791223814 no 515 0.129794583336263 685 3010129
SGTC_1038 k292-0204 154 µM 1.12734849575928 0.151997881341122 no 516 0.1297975829433 642 4454212
SGTC_314 1671-0008 2.74 µM 1.12569889015912 0.152357270757317 no 517 0.13014649684439 720 3913060
SGTC_1565 sinapyl alcohol 95.1 µM 1.12561643418513 0.152375249721931 no 518 0.130163954414696 642 5280507 A phenol propionate derived from cinnamic acid.
SGTC_94 0334-0113 514.748 µM 1.12475267349716 0.152563671505576 no 519 0.13034692713711 665 6795178
SGTC_2862 9027634 71.43 µM 1.12343232781971 0.15285199192621 no 520 0.130626963193886 637 5012562
SGTC_2299 7976368 114.88 µM 1.12223328786551 0.153114135989677 no 521 0.130881631312702 669 2979718
SGTC_173 1273-0061 2.693 µM 1.11288655048837 0.155167807193041 no 522 0.132878578534317 709 2847414 YPL266W DIM1
SGTC_2753 fluvastatin 17.09 µM 1.11265983023897 0.155217847165848 no 523 0.132927276938281 702 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_3285 9112818 20.8695 µM 1.10809324523793 0.156228017047889 no 524 0.133910773932304 746 17017947 YPR165W RHO1
SGTC_1073 triclabendazole 3.09 µM 1.1059539028788 0.156702745391582 no 525 0.13437323605883 743 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_12 0849-0099 9.267 µM 1.10514583002422 0.156882306674919 no 526 0.134548202368681 686 6071388
SGTC_1957 st077035 62.4 µM 1.10496564758841 0.156922363334683 no 527 0.134587237312644 713 705593
SGTC_1463 k081-0032 34.1 µM 1.10363844327804 0.157217623658977 no 528 0.134875003979066 579 977755
SGTC_3316 9136639 10.545 µM 1.10199191706776 0.157584430218727 no 529 0.135232592824832 690 4903665
SGTC_2457 5731572 11.68 µM 1.10165468284721 0.157659627240492 no 530 0.135305912711777 710 2865357
SGTC_432 NS 1619 61.3 µM 1.10127024145018 0.157745379343202 no 531 0.135389529394498 634 4552 A K+/calcium channel activator.
SGTC_867 0518-0118 155 µM 1.09766638167225 0.158550732662448 no 532 0.136175097381421 717 6848158
SGTC_1945 st075991 56.6 µM 1.09684470871834 0.158734728457696 no 533 0.136354641157559 649 1084980
SGTC_3032 9089427 49.47 µM 1.09540903293296 0.159056552673064 no 534 0.136668739262599 672 17173707
SGTC_989 1501-0895 10.3 µM 1.09483319164686 0.159185754543321 no 535 0.13679486110237 716 2830112
SGTC_820 1582-0060 59.9 µM 1.09437568631072 0.159288454292625 no 536 0.136895121479959 719 3848840
SGTC_3345 9148410 3.559 µM 1.0939842176512 0.159376364719742 no 537 0.136980950059364 694 4903596
SGTC_818 4072-2707 53.5 µM 1.09365615250835 0.159450061353982 no 538 0.137052905882558 686 882871
SGTC_3126 9127922 49.47 µM 1.09064065676306 0.160128507851993 no 539 0.137715516154953 688 45595682
SGTC_3178 9107506 49.47 µM 1.08324278617471 0.161800913051886 no 540 0.139350336517119 725 8897194
SGTC_420 mitomycin C 81.9 mM 1.082075462945 0.16206584082224 no 541 0.139609498855744 715 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2718 lomofungin 53.02 µM 1.08122844721617 0.162258250543079 no 542 0.139797753447924 698 5351222 A RNA synthesis inhibitor.
SGTC_757 1066-0008 322 µM 1.07918569132452 0.162722898472333 no 543 0.140252478494017 767 6842497
SGTC_3056 9094900 49.47 µM 1.07787283752377 0.163021978310059 no 544 0.14054525434778 705 25236784
SGTC_3140 9094243 49.47 µM 1.07780122520569 0.163038302507448 no 545 0.1405612363341 741 19291112
SGTC_2031 5180455 200 µM 1.07740064046209 0.163129636342816 no 546 0.140650659065967 687 29949
SGTC_659 k018-0002 107 µM 1.07250886616769 0.164247648888393 no 547 0.141745766903401 741 6797879 YHR007C ERG11
SGTC_449 xestospongin c 11.1929 µM 1.07116714843814 0.164555164071269 no 548 0.142047140018084 751 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1902 st060212 70.5 µM 1.07109554472776 0.16457158577464 no 549 0.142063235637991 738 688944
SGTC_2652 actinonin 100 µM 1.06572744277338 0.165805738352569 no 550 0.143273434226876 714 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_422 cantharidin 155 µM 1.06529722462049 0.16590490588582 no 551 0.143370724168945 727 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1056 3448-1962 115 µM 1.06452022995943 0.166084104332096 no 552 0.143546547493055 703 715507
SGTC_3074 9116018 49.47 µM 1.0621387129153 0.166634132859648 no 553 0.144086358824536 697 17027303
SGTC_2580 diallyl disulphide 81.36 µM 1.05947517218348 0.16725068780076 no 554 0.144691715262368 689 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1496 4469-0713 57.4 µM 1.05834346201005 0.167513100001922 no 555 0.144949442600668 740 746691
SGTC_100 0086-0128 49.5915 µM 1.05713363861125 0.167793917665911 no 556 0.145225300459872 780 93297
SGTC_1641 st009299 47.1 µM 1.05592779485441 0.168074113031715 no 557 0.145500602193723 678 4046054
SGTC_1477 0139-0234 16 µM 1.05577307454441 0.168110086332367 no 558 0.14553595120534 761 620880
SGTC_3067 9117431 49.47 µM 1.05408382110889 0.16850316909981 no 559 0.145922271352072 692 17150885
SGTC_553 k007-0256 45.7 µM 1.05202553007565 0.168982923523105 no 560 0.146393918308993 761 6287000
SGTC_2699 st077704 54.6 µM 1.05135142294606 0.169140237557358 no 561 0.146548608784357 746 645852
SGTC_3077 9117319 49.47 µM 1.0507608843899 0.169278126733866 no 562 0.146684212513588 704 17154678
SGTC_411 enrofloxacin 100 µM 1.0507516178744 0.169280291015395 no 563 0.146686341028551 765 71188 A bacterial gyrase inhibitor.
SGTC_1058 3448-5425 97.3 µM 1.05040873629689 0.169360386709713 no 564 0.146765115363528 717 7279705
SGTC_1122 capsaicin 818.572 nM 1.04987427919836 0.169485282137675 no 565 0.146887959250477 769 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1157 4092-0394 27.6 µM 1.04050190065925 0.17168508139478 no 566 0.149053390739395 821 3659885
SGTC_1060 3448-7350 82 µM 1.04041846031815 0.1717047473071 no 567 0.149072764404439 765 570178
SGTC_814 3342-0569 96 µM 1.0396012531043 0.171897429542351 no 568 0.149262597246909 787 4346283
SGTC_1755 st041960 45.185 µM 1.03724089301348 0.172454733406029 no 569 0.149811802253347 765 2257073
SGTC_469 w7 172 µM 1.03268118965689 0.173534582761624 no 570 0.150876559587472 742 45115570 A P450 inhibitor.
SGTC_186 3455-3465 67.277 µM 1.02973600712595 0.174234356361736 no 571 0.151566973973726 696 755278
SGTC_2612 dictamnine 15.46 µM 1.02883700894067 0.17444831451881 no 572 0.151778136293735 733 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1289 0976-0073 69.1 µM 1.02827760324684 0.174581535149785 no 573 0.151909631626769 806 3391136
SGTC_1710 st031758 61.5 µM 1.02633750683135 0.175044063145305 no 574 0.152366261893316 758 5394341
SGTC_3233 9132340 49.47 µM 1.02610742697572 0.175098966769964 no 575 0.152420474942439 763 17682950
SGTC_1799 st045822 46.1415 µM 1.02459199360151 0.175460865341085 no 576 0.152777871935792 778 3674992
SGTC_83 0170-0301 39.027 µM 1.02440476265298 0.175505610592501 no 577 0.1528220666802 704 3089716
SGTC_2178 5812956 200 µM 1.02425413540822 0.17554161338369 no 578 0.152857627492869 755 5403383
SGTC_837 0091-0265 12.5 µM 1.0225885203965 0.1759400392212 no 579 0.153251219782524 809 759367
SGTC_2121 5257820 149.641 µM 1.02209755182676 0.176057591257099 no 580 0.153367365889158 853 791256
SGTC_1271 0832-2808 169 µM 1.01635383428267 0.17743649458125 no 581 0.154730460644407 827 3663794
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.01405124145907 0.177991190900933 no 582 0.155279151105138 710 61125 An anti-inflammatory.
SGTC_2242 6630449 61.2675 µM 1.01393161416472 0.178020039053141 no 583 0.15530769243445 675 691249 YDR170C SEC7
SGTC_1892 st058411 7.36 µM 1.01367887328747 0.178080997272606 no 584 0.155368004109076 851 3934738
SGTC_2762 leflunomide 42.06 µM 1.01307871061491 0.178225802388838 no 585 0.155511283129168 818 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_2818 7996756 12.99 µM 1.0127914675571 0.178295133623633 no 586 0.155579888544217 711 2241621
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 1.01176080096759 0.178544043259308 no 587 0.155826218280073 815 442882
SGTC_703 3875-0075 71.8 µM 1.01126148108063 0.178664709442879 no 588 0.155945648350959 851 2850814
SGTC_3268 9137683 49.47 µM 1.01092398958673 0.178746297078386 no 589 0.156026405582593 771 1953228
SGTC_2993 9054257 71.4286 µM 1.01038148331822 0.178877495616646 no 590 0.156156277878752 791 6470217 YGL055W OLE1
SGTC_457 grayanotoxin iii 135 µM 1.00987710751873 0.178999527120013 no 591 0.156277085877054 827 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1489 4065-0444 182 µM 1.00841746883814 0.179352975337333 no 592 0.156627045067457 778 2877968
SGTC_868 0527-0199 213 µM 1.00696821821304 0.179704341943982 no 593 0.156975023647488 803 2849450
SGTC_2317 5986382 200 µM 1.00612680075149 0.179908539472333 no 594 0.15717728899697 837 877883
SGTC_501 nsc-95397 161 µM 1.00407158827295 0.180407916517963 no 595 0.157672054436468 780 262093
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 1.00382183595374 0.180468660726397 no 596 0.157732248676672 870 1377
SGTC_2120 5538279 151.968 µM 1.00321217613313 0.180616994721248 no 597 0.157879249679199 800 2058197
SGTC_2495 cafestol 54.53 µM 1.00309829602414 0.180644710926563 no 598 0.15790671838738 732 16667697 An anti-infammatory.
SGTC_597 k018-0003 82.8 µM 1.00308998453167 0.180646733886722 no 599 0.15790872330251 878 6786234
SGTC_1454 4239-0054 42.6 µM 0.997125306038468 0.182102157527769 no 600 0.159351845517468 865 1340767
SGTC_2905 7799065 20.05 µM 0.996745896617527 0.18219498341375 no 601 0.159443932819158 771 1296806
SGTC_963 1269-2853 151 µM 0.994316884212446 0.182789963415211 no 602 0.160034309116684 763 3668223
SGTC_3291 9121177 71.43 µM 0.992737223370888 0.183177547161795 no 603 0.160419014924977 708 17015612
SGTC_2383 9036125 200 µM 0.988787477894907 0.184148893168836 no 604 0.161383566068114 782 79580
SGTC_781 4335-2806 94.4 µM 0.983518695294276 0.185449605498497 no 605 0.162676109345329 907 845254
SGTC_2273 7815444 169.05 µM 0.983023488262748 0.185572150510405 no 606 0.162797939313259 801 2824616
SGTC_377 3970-0964 33.1 µM 0.982248977657082 0.185763913324417 no 607 0.1629886020014 901 16481235
SGTC_3311 9131146 2.8755 µM 0.981217658701463 0.186019450626069 no 608 0.163242708918686 816 4900406 YPR165W RHO1
SGTC_2679 rapamycin 1 nM 0.980957696461971 0.186083897710135 no 609 0.16330680167419 892 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1522 st012842 45.6 µM 0.980001882281641 0.186320972009067 no 610 0.163542594763148 734 3491067 YOR116C RPO31
SGTC_2350 9023895 38.85 µM 0.979257729914312 0.186505676506998 no 611 0.163726325260579 805 2997209
SGTC_2723 salbutamol 83.58 µM 0.978870573455701 0.18660181662942 no 612 0.163821966782657 748 9884233 β2-adrenoceptor agonist
SGTC_2510 benzyl isothiocyanate 8.31 µM 0.976197306231116 0.187266489381389 no 613 0.1644833489477 785 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1218 1348-1416 30.7 µM 0.975363934186827 0.187473995328516 no 614 0.164689883501733 821 6787668
SGTC_285 1486-1325 46 µM 0.974743077641811 0.187628678189785 no 615 0.16484385951698 856 22310230
SGTC_2152 5568786 200 µM 0.974690836588296 0.187641697345405 no 616 0.164856819852055 821 5399883
SGTC_534 k292-0788 63.4 µM 0.97368945157456 0.187891363496022 no 617 0.165105378190596 918 4146317
SGTC_2379 9035213 200 µM 0.970357978127579 0.18872344459066 no 618 0.165934043505248 896 646551
SGTC_393 acivicin 6.25 µM 0.970340658776759 0.188727776261554 no 619 0.165938358503795 769 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_732 3970-1727 52.7 µM 0.968593778854672 0.18916499590243 no 620 0.166373954277583 843 1275699
SGTC_247 mechlorethamine 29.705 µM 0.967525041723203 0.18943279314403 no 621 0.166640814479332 787 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_168 3970-0862 530.542 µM 0.965177340535865 0.190021883606822 no 622 0.167227997199593 958 3135186
SGTC_5 0352-0601 109.883 µM 0.965039625090918 0.190056474402489 no 623 0.167262482523451 802 762456
SGTC_370 0180-0345 38.7 µM 0.961829074015819 0.190863983746018 no 624 0.168067735463163 770 3989527
SGTC_943 3253-1379 105 µM 0.96119592243694 0.191023480497483 no 625 0.168226833115286 832 668464
SGTC_2019 4016004 108 µM 0.960589035854933 0.191176437556071 no 626 0.16837942183735 767 45595336
SGTC_3303 9125618 40.5795 µM 0.95908045862725 0.191556978004871 no 627 0.168759106981268 899 22695467
SGTC_692 k241-0027 77.8 µM 0.956523808274983 0.192202954839631 no 628 0.169403830908534 834 3600480
SGTC_554 4483-2211 187 µM 0.956218346444268 0.192280223464342 no 629 0.169480966397928 826 747107
SGTC_1741 st038134 10.228 µM 0.956132899868788 0.192301841150498 no 630 0.169502547475406 896 1272587
SGTC_2393 9031399 185.94 µM 0.955000664573633 0.192588433065884 no 631 0.169788680441612 857 1526623 YDL150W RPC53
SGTC_850 0388-0143 75.9 µM 0.953048679047628 0.193083133128351 no 632 0.170282703536713 796 67273
SGTC_391 gliotoxin 8.33 µM 0.952219170990242 0.193293593605324 no 633 0.170492920170766 898 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_844 0330-0132 15.3 µM 0.951470059525379 0.193483776333572 no 634 0.17068290517985 904 2828079
SGTC_2507 purpurin 79.67 µM 0.95083893323151 0.193644093815279 no 635 0.170843072659966 846 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_2984 9022109 38.96 µM 0.949957025543355 0.193868249934398 no 636 0.171067044581258 835 6459207
SGTC_1720 st037298 9.481 µM 0.949560093889599 0.193969190379764 no 637 0.171167911792774 809 597396
SGTC_2673 kobusone 100 µM 0.947742080172644 0.194431923715253 no 638 0.171630386482409 896 6710676 An epoxy ketone and protein crosslinker.
SGTC_2090 5301565 104.445 µM 0.945775897624697 0.194933125655434 no 639 0.172131450717906 888 2056344
SGTC_707 0865-0008 204 µM 0.945449071103205 0.195016513476601 no 640 0.17221482996944 911 723043
SGTC_1734 st037168 69.4 µM 0.945360393259291 0.195039142834961 no 641 0.172237457707111 826 708907
SGTC_2369 9071472 200 µM 0.943635149988561 0.19547971861326 no 642 0.172678061824437 881 17296037
SGTC_50 0929-0078 56.389 µM 0.943235181611928 0.195581944872496 no 643 0.17278031092471 793 1377751
SGTC_1993 st073995 70.8 µM 0.9370286018122 0.197172415748441 no 644 0.174371922831864 887 3098394
SGTC_113 0099-0221 2.5 µM 0.935974608222529 0.197443282735631 no 645 0.174643130676198 836 89219
SGTC_2133 5320837 200 µM 0.934721149002556 0.197765703364881 no 646 0.174966012380545 800 2841355
SGTC_2979 9012552 45.46 µM 0.932818724294459 0.198255661352593 no 647 0.175456785927658 834 17100905
SGTC_1995 st072814 61.1 µM 0.930724627150463 0.198795829695685 no 648 0.175998013583968 836 5769371
SGTC_1156 4092-0367 4.88 µM 0.930552376194793 0.19884030095753 no 649 0.176042579525043 878 1357585
SGTC_453 enantio-paf c16 10 µM 0.930379610775698 0.198884911065386 no 650 0.176087285747621 946 13871343 A lipid and platelet activating factor
SGTC_2302 7771753 200 µM 0.929749479828523 0.199047669569406 no 651 0.176250404599183 878 2203047
SGTC_3331 9141060 1.957 µM 0.926208541501126 0.199963761300572 no 652 0.177168807245843 830 4906567 YPR165W RHO1
SGTC_382 3229-0966 23.2 µM 0.925414606353407 0.200169511155639 no 653 0.177375141966523 910 5722370
SGTC_2068 5226020 147 µM 0.925249237071624 0.200212382935871 no 654 0.177418138647603 928 1810509
SGTC_3063 1327-0034 4 µM 0.925094369286892 0.200252537219207 no 655 0.177458410862927 857 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_24 0417-1663 219 µM 0.92477162065507 0.200336235376193 no 656 0.177542357786271 867 4329390
SGTC_2049 5262831 67.185 µM 0.924637189401456 0.200371103530079 no 657 0.177577330749757 867 763417
SGTC_2054 5233173 129 µM 0.924033085443996 0.200527838204393 no 658 0.177734545080695 903 6889
SGTC_821 1114-0266 29.2 µM 0.924025087862387 0.200529913669333 no 659 0.177736626990791 858 3123235
SGTC_1080 nisoldipine 24.4 µM 0.921293288987457 0.201239601604588 no 660 0.178448661965004 896 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2098 5376439 882.5 nM 0.920410486377093 0.2014692644834 no 661 0.178679145399839 938 2844116
SGTC_2394 5221648 200 µM 0.920151493539555 0.201536671779184 no 662 0.178746799186216 979 788586
SGTC_1931 st074438 57.1 µM 0.919754704408776 0.201639969112192 no 663 0.178850479223942 864 2787313
SGTC_454 lyso-paf C-16 6.67 µM 0.915471315604569 0.20275709471198 no 664 0.179972127188668 934 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1726 st035556 14.5795 µM 0.914159571368149 0.203099941307429 no 665 0.180316502063357 932 5919439
SGTC_3196 9111891 49.47 µM 0.913820659641057 0.203188577866263 no 666 0.180405544420707 891 18891510
SGTC_2227 7312221 64.1025 µM 0.913604297718532 0.203245175695983 no 667 0.180462403663686 917 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1932 st074806 40.9 µM 0.912512140198832 0.203531015334492 no 668 0.180749590843497 956 17251235
SGTC_2966 9084041 48.03 µM 0.912104424573711 0.203637784164746 no 669 0.180856874701327 814 17741380
SGTC_2865 9030313 51.95 µM 0.911425843685836 0.203815558740009 no 670 0.181035520902748 826 42562754
SGTC_2401 5128683 200 µM 0.909855190357749 0.204227393088707 no 671 0.181449441978738 834 708373
SGTC_991 3996-0057 64.7 µM 0.909367639063037 0.204355332564864 no 672 0.181578048884129 861 715343
SGTC_2149 5554786 194.827 µM 0.906978388933607 0.204982990797343 no 673 0.182209112803387 923 745063 YPR165W RHO1
SGTC_2066 5222451 176 µM 0.906760152959712 0.205040378654507 no 674 0.182266822918048 978 2281147
SGTC_961 1252-1571 372 µM 0.90579129623752 0.205295266835114 no 675 0.18252316437059 909 6813498
SGTC_1816 st051957 91.6 µM 0.905418049735013 0.205393511249145 no 676 0.182621978501495 920 674121
SGTC_1003 4049-0218 100 µM 0.90539747695991 0.20539892714248 no 677 0.182627425956144 922 295161
SGTC_3240 9133527 49.47 µM 0.904906187640855 0.205528286884561 no 678 0.182757544348181 876 17617455
SGTC_3267 9137951 49.47 µM 0.90390532850792 0.205791969344021 no 679 0.183022801732089 900 16643986
SGTC_3198 9112019 49.47 µM 0.902453923651781 0.206174707235506 no 680 0.183407893615802 895 45595555
SGTC_1523 st012844 44.7 µM 0.902346314389025 0.206203100772255 no 681 0.183436464986972 895 4274103
SGTC_1727 st034309 9.9045 µM 0.902022807478677 0.206288474532326 no 682 0.18352237612213 976 870305
SGTC_2836 9010338 19.48 µM 0.899868559614821 0.206857516482115 no 683 0.184095101763146 865 2994051
SGTC_2786 7743617 45.45 µM 0.899102487474779 0.207060097241677 no 684 0.184299036637906 813 583674
SGTC_3058 9093861 49.47 µM 0.897029970134387 0.20760874345056 no 685 0.184851462484668 900 17217477
SGTC_1487 3970-0795 2.82 µM 0.896966082718433 0.207625669654194 no 686 0.184868507897844 941 3765103
SGTC_2181 6316240 54.2555 µM 0.893923386327146 0.208432739281043 no 687 0.185681442061006 865 12779990
SGTC_2168 5727979 200 µM 0.893477709840308 0.208551109304324 no 688 0.185800701878489 849 695210
SGTC_1312 1218-2183 165 µM 0.891984164245263 0.208948078338939 no 689 0.186200710200183 951 6744073
SGTC_225 nsc-122657 1.016 µM 0.891338591970106 0.209119802480757 no 690 0.18637377543934 802 275685
SGTC_2957 9076800 11.52 µM 0.888782756663946 0.20980047752782 no 691 0.187059922368655 840 16459615
SGTC_691 1548-0686 185 µM 0.888655971567663 0.209834277055818 no 692 0.187094000092477 916 46495133
SGTC_744 1594-0068 283 µM 0.888439010035789 0.209892124065836 no 693 0.18715232464875 952 668392
SGTC_1833 st055984 71 µM 0.888415520136518 0.209898387583707 no 694 0.187158639981678 894 676288
SGTC_275 trichlorophene 5.69 µM 0.886719074224244 0.210351030673986 no 695 0.187615083191848 1008 62616
SGTC_1753 st043925 64 µM 0.886146731850004 0.210503871382801 no 696 0.187769231809502 952 670181
SGTC_983 1491-0821 12.2 µM 0.884324272382334 0.210990982603495 no 697 0.188260594589002 941 46495113
SGTC_1827 berberine 7.24 µM 0.884047570568958 0.211064997847996 no 698 0.18833526691348 836 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1653 st012112 65 µM 0.883951607755093 0.211090670590762 no 699 0.188361168250526 888 720429
SGTC_496 calpeptin 138 µM 0.882918352207415 0.211367211338857 no 700 0.188640193589288 849 73364 A calpain inhibitor.
SGTC_2907 7721985 69.9 µM 0.882748850269358 0.211412597127707 no 701 0.188685991031539 933 3267881
SGTC_1304 1165-0502 251 µM 0.882570847912802 0.211460265129606 no 702 0.188734092564706 944 767425
SGTC_224 benfluorex 43.875 µM 0.882568865346709 0.211460796084781 no 703 0.188734628355611 917 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1037 k284-1091 78.7 µM 0.881907155299216 0.211638053648372 no 704 0.188913508674844 876 3334711
SGTC_795 0685-0265 78 µM 0.881449677302988 0.211760652773931 no 705 0.189037239920271 963 302754
SGTC_2732 terfenadine 20 µM 0.880709721670061 0.211959040782954 no 706 0.189237476781541 919 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2911 7942208 15.64 µM 0.87790901109176 0.212710917399616 no 707 0.189996549327419 882 1243384
SGTC_1588 farnesol 29.9 µM 0.877841145614803 0.212729155816983 no 708 0.190014966004292 922 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2460 5552655 174.22 µM 0.877751667119717 0.212753203991594 no 709 0.19003924949001 907 5401989
SGTC_3175 9106517 49.47 µM 0.876959840976189 0.212966083761175 no 710 0.190254225567225 922 41468073
SGTC_849 0386-0493 241 µM 0.873350921831414 0.213937902333639 no 711 0.191235916444202 929 726119
SGTC_1821 st053465 65.6 µM 0.8729931597113 0.214034381844299 no 712 0.191333403056199 899 675086
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.872859040231346 0.214070557044479 no 713 0.191369957125776 1027 6708561
SGTC_717 1532-0246 73.2 µM 0.872735376000445 0.214103915369276 no 714 0.191403665424532 915 9561992
SGTC_1785 bathophenanthroline 24 µM 0.872250591066332 0.214234714877505 no 715 0.191535842805944 905 72812 An iron chelator.
SGTC_3245 9134821 49.47 µM 0.871072159969878 0.214552860384386 no 716 0.191857377010844 972 17014901
SGTC_2678 equilin 100 µM 0.869578526705377 0.214956496619676 no 717 0.192265388447879 977 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_3216 9129716 49.47 µM 0.868578387610916 0.215227018393684 no 718 0.192538889956552 885 8056934
SGTC_3191 9110352 49.47 µM 0.867097207404266 0.215628016952898 no 719 0.192944375291984 918 17122424
SGTC_2029 5175081 200 µM 0.866789810034939 0.21571129260972 no 720 0.19302859316905 1007 1380876
SGTC_1141 3253-0389 52.6 µM 0.86665484852204 0.21574786032312 no 721 0.193065575761097 959 5402031
SGTC_1093 fluphenazine 7.97 µM 0.864053525280954 0.216453388567722 no 722 0.193779243851592 969 6602611 An atypical antipsychotic.
SGTC_273 hydroxyurea 18.1 mM 0.863644081465373 0.216564558989057 no 723 0.193891720291747 1012 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_806 3966-4455 5.86 µM 0.860425705427438 0.217439548136342 no 724 0.194777210547064 864 714982
SGTC_294 k038-0071 157 µM 0.858598015880556 0.217937354618589 no 725 0.195281166574242 963 24152826
SGTC_3271 9137798 49.47 µM 0.857833267100931 0.218145843549759 no 726 0.1954922686534 881 6498326
SGTC_2529 gangaleoidin 93.61 µM 0.85685283357693 0.218413301412808 no 727 0.195763111228522 968 4565183
SGTC_331 k048-0133 24.5 µM 0.853862074427256 0.219230332894842 no 728 0.196590707722996 922 6813582
SGTC_2959 9079155 11 µM 0.852633433593971 0.219566487975886 no 729 0.196931307941116 913 16189457
SGTC_2945 9067681 61.76 µM 0.850697572642125 0.220096738114677 no 730 0.197468685965123 980 16456930
SGTC_169 k015-0017 16.025 µM 0.850261552353153 0.220216269359141 no 731 0.197589843603973 920 1840002
SGTC_2437 5741531 144.16 µM 0.850149968363769 0.220246865139592 no 732 0.197620856841319 1024 2262990
SGTC_3079 9117512 49.47 µM 0.849935260652132 0.220305743793664 no 733 0.197680540178096 1027 7185044
SGTC_1267 0828-0272 9.49 µM 0.847470390564627 0.220982323894151 no 734 0.198366492096267 1012 745334
SGTC_474 dl-dihydrosphingosine 5 µM 0.847387714313739 0.221005038223812 no 735 0.198389525047575 1007 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_63 0099-0242 26.702 µM 0.845766710496629 0.221450659864726 no 736 0.198841449861 1021 3898502 YLR359W ADE13
SGTC_715 0868-0130 184 µM 0.84482022150105 0.221711091542542 no 737 0.199105611260598 978 2876258
SGTC_157 1348-1695 65.819 µM 0.844605000212973 0.221770335279442 no 738 0.19916570817592 960 5380510
SGTC_2726 cimetidine 79.27 µM 0.844042324592164 0.221925265124988 no 739 0.199322877471422 996 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_1897 st060201 15 µM 0.843058768402214 0.222196230667257 no 740 0.199597788485947 922 611878
SGTC_1321 1326-2144 215 µM 0.841538526307326 0.222615422104608 no 741 0.200023155690783 998 3513030
SGTC_1807 st050092 58.9 µM 0.841423351043214 0.22264719888452 no 742 0.200055404186106 936 5008496
SGTC_808 0711-0032 135 µM 0.840732926463678 0.222837740772058 no 743 0.200248785118045 996 4252555
SGTC_2516 gossypol 71.55 µM 0.83962118045783 0.223144753208007 no 744 0.200560409870595 1007 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_3006 9075424 71.4286 µM 0.83895368658096 0.223329199549869 no 745 0.200747649639138 948 7465181
SGTC_2132 5317594 122.667 µM 0.838315437836637 0.223505645796578 no 746 0.20092678390012 930 794577
SGTC_3025 9087895 49.47 µM 0.837984887362525 0.223597058868572 no 747 0.201019595625789 1045 17173641
SGTC_1480 1070-0044 41.2 µM 0.837923242330002 0.223614109031007 no 748 0.201036907118687 998 3124987
SGTC_1638 st008370 60.6 µM 0.836911928551922 0.223893929958584 no 749 0.20132103740364 982 24207134
SGTC_2456 5770359 74.46 µM 0.836527964092109 0.224000221375982 no 750 0.201428975871897 1018 3118787
SGTC_1431 4049-0260 9.09 µM 0.835748381301033 0.224216118477655 no 751 0.201648235562819 1002 3854841
SGTC_2727 riluzole 51.77 µM 0.835624283854156 0.224250496834239 no 752 0.20168315147851 975 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_596 1155-0152 116 µM 0.835202702845326 0.224367308552086 no 753 0.201801794072607 1005 280313
SGTC_2224 6650123 117.647 µM 0.833223235408414 0.224916241203187 no 754 0.202359420299954 972 2908370
SGTC_381 3461-2219 42.7 µM 0.831269848585844 0.225458686864065 no 755 0.202910601847185 1012 2883159
SGTC_1765 st044815 90.4 µM 0.830158791601907 0.225767551892262 no 756 0.203224505276623 983 645695
SGTC_630 4356-0227 183 µM 0.827900708188594 0.226396018093233 no 757 0.203863366927743 983 779312
SGTC_3093 9117344 49.47 µM 0.827261672815607 0.226574052609289 no 758 0.204044381213979 946 24824913
SGTC_1102 cgs 12066b 26.1 µM 0.827081881339483 0.226624156548794 no 759 0.204095326518933 969 6438352 A 5-HT1B full agonist.
SGTC_3292 9120825 59.784 µM 0.824933454880936 0.227223359507135 no 760 0.204704685799377 1034 24824900
SGTC_921 1561-0023 372 µM 0.82445707945405 0.227356342964741 no 761 0.204839946844276 1073 24050882
SGTC_1888 azatryptophan 97.5 µM 0.824397325950156 0.227373026658357 no 762 0.204856916880132 907 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_775 4577-0580 57.3 µM 0.824138856712133 0.227445201442494 no 763 0.204930331948651 1021 2006902
SGTC_1635 st007035 42.4 µM 0.820854701484076 0.228363389763246 no 764 0.205864517968426 1061 3716403
SGTC_1572 epiandrosterone 68.9 µM 0.820836902330896 0.228368371742021 no 765 0.20586958785494 1015 441302 A steroid.
SGTC_2774 tamoxifen 10.92 µM 0.820730557827495 0.228398138816003 no 766 0.205899880421583 1039 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_311 1315-0136 58 µM 0.820088699550648 0.228577848762162 no 767 0.206082771908355 1008 6759207
SGTC_1090 efavirenz 20.7 µM 0.819354852019207 0.228783411486804 no 768 0.206291992853797 1011 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_97 0535-0701 19.132 µM 0.817563836332011 0.229285539800291 no 769 0.206803142161373 962 2832013 YGL099W LSG1
SGTC_680 0417-1641 114 µM 0.817346380326774 0.229346547699474 no 770 0.206865254309658 960 2835990
SGTC_583 1488-1091 88.9 µM 0.816956052498761 0.229456078101758 no 771 0.20697677168151 1161 4303273
SGTC_2490 carminic acid 95.39 µM 0.81609168101285 0.229698734820995 no 772 0.207223850769797 971 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2234 tolnaftate 200 µM 0.81607920321514 0.229702238789892 no 773 0.20722741880337 1003 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_3113 9123498 49.47 µM 0.81598725640972 0.229728059873994 no 774 0.207253712166595 1098 8897275
SGTC_433 pimozide 108 µM 0.81515067932194 0.229963067412523 no 775 0.207493032690506 973 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_1597 7-benzyloxygramine 47.5 µM 0.814273609274644 0.230209594470825 no 776 0.207744112380223 1060 260807
SGTC_114 0364-0001 490.298 µM 0.811804058452825 0.230904529893192 no 777 0.20845203646818 1012 4003655
SGTC_631 k072-0230 41.5 µM 0.810825952548025 0.231180093902395 no 778 0.208732814205338 1057 5773147
SGTC_2872 9044037 25.97 µM 0.809990330255489 0.231415660950004 no 779 0.208972866666298 1041 6465195
SGTC_3072 9116419 49.47 µM 0.809904717078467 0.231439803386539 no 780 0.208997470276285 998 17170162
SGTC_2854 9024559 71.43 µM 0.809679288016167 0.231503379836788 no 781 0.20906226249096 1006 3163529
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.809386282825197 0.231586028940395 no 782 0.209146494931423 960 688803
SGTC_2171 5739187 198.077 µM 0.80918474170548 0.231642887966453 no 783 0.209204445093966 997 2262761
SGTC_1575 cyproterone acetate 48 µM 0.808768450839846 0.231760357079866 no 784 0.209324173286306 999 9880 An androgen receptor antagonist and liver toxin.
SGTC_804 1595-0054 20.9 µM 0.8071155080417 0.232227112465122 no 785 0.209799969099607 983 761523 Stimulates phospholipase C.
SGTC_760 0568-0725 82.9 µM 0.806904956553554 0.232286605199549 no 786 0.209860621482939 1071 3916171
SGTC_2701 st077767 14.721 µM 0.804844033765596 0.232869380260561 no 787 0.210454843889189 1053 5721188
SGTC_1870 st057514 26.5 µM 0.80221377853863 0.23361432604825 no 788 0.211214653719032 1034 5393161
SGTC_3189 9110682 49.47 µM 0.801110444280121 0.233927207392798 no 789 0.211533855165296 1026 17122418
SGTC_2030 5175110 200 µM 0.800767547355574 0.234024492691102 no 790 0.211633114872265 1057 2831986
SGTC_3066 9117245 49.47 µM 0.800699085713589 0.23404391902869 no 791 0.211652935994766 1074 17176980
SGTC_3031 9088762 49.47 µM 0.800638191484833 0.234061198824951 no 792 0.211670567100911 1072 205253
SGTC_1199 1638-0010 4.46 µM 0.800529243914186 0.234092116355442 no 793 0.211702113551621 1003 3111136
SGTC_2416 tofa 880 nM 0.799013679278274 0.234522443182865 no 794 0.212141240076182 925 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1097 itavastatin 7.23 µM 0.798984533025155 0.234530723206564 no 795 0.212149690258756 1089 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2484 5809818 12.04 µM 0.798886613470543 0.234558541902318 no 796 0.212178080875999 994 2870548
SGTC_2253 7938677 135.83 µM 0.796880078187171 0.235128995182169 no 797 0.212760340980677 1049 2301972
SGTC_2334 9017922 200 µM 0.796859605881932 0.23513481935674 no 798 0.21276628647516 1057 3163164
SGTC_1499 4480-0877 67.3 µM 0.796141545288988 0.235339151112371 no 799 0.212974884449601 1004 2861909
SGTC_2385 9074692 200 µM 0.792922844926032 0.236256269733548 no 800 0.213911388218357 1024 17046906
SGTC_1376 2910-0861 41.3 µM 0.791732928261942 0.236595815624395 no 801 0.214258209031653 1064 1112859
SGTC_2103 5378138 10 µM 0.790490104453692 0.23695074518751 no 802 0.214620799518248 1119 244142
SGTC_2136 5328288 199.296 µM 0.790251886677505 0.237018809585825 no 803 0.214690339620145 965 262395
SGTC_812 4251-0442 148 µM 0.789716821751565 0.237171729333257 no 804 0.21484658253127 1061 5723007
SGTC_1420 4'-methoxyflavone 42 µM 0.789401916278073 0.237261753583773 no 805 0.214938568125127 1079 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_2882 9058044 58.44 µM 0.788329895374701 0.237568360416715 no 806 0.215251882657233 1056 18076804
SGTC_1044 1222-0021 1.78 µM 0.788133022335675 0.237624691355815 no 807 0.215309450613543 1006 4306703
SGTC_1793 st048256 72.231 µM 0.787778170786352 0.237726242918339 no 808 0.215413235876453 1024 672022
SGTC_1818 st052136 56.3 µM 0.787583910425885 0.237781846510743 no 809 0.215470064496841 992 674169
SGTC_560 2332-1943 155 µM 0.786651379406526 0.23804886630852 no 810 0.215742986697482 1057 21177716
SGTC_2597 laccaic acid a 100 µM 0.782058388907763 0.239366412714256 no 811 0.21709012985846 1029 5491415 A textile dye.
SGTC_1763 st044482 94.5 µM 0.781418174166542 0.239550380645753 no 812 0.217278292695608 1063 88505
SGTC_3172 9105863 49.47 µM 0.780265236300201 0.239881875930646 no 813 0.217617385283594 1049 2348785
SGTC_1224 0823-0416 294 µM 0.779450432060247 0.240116301093306 no 814 0.217857212857529 1078 3598164
SGTC_1145 3546-0597 10.2 µM 0.779391257417019 0.240133330935326 no 815 0.217874636118771 1040 875334
SGTC_2459 5811157 9.22 µM 0.778595470868548 0.240362413909352 no 816 0.21810902394499 1085 2870684 YBR192W RIM2
SGTC_3201 9113999 49.47 µM 0.775410935277608 0.241280336071769 no 817 0.21904843773832 1022 16649224
SGTC_389 tpck 16.7 µM 0.775176121263086 0.241348095048134 no 818 0.219117798076738 1057 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2065 5221596 34.26 µM 0.77382873503034 0.241737102605049 no 819 0.219516038659418 1035 788581
SGTC_76 0433-0009 400.328 µM 0.771747016028223 0.242338789837368 no 820 0.220132139171068 954 2841569
SGTC_1262 0737-0114 49.6 µM 0.771349723464232 0.242453712979898 no 821 0.22024983351604 1129 765919
SGTC_1276 0871-0068 94.2 µM 0.769064552459695 0.243115307651902 no 822 0.220927495082635 1056 3414906
SGTC_2852 9023854 51.95 µM 0.767706649046848 0.243508904992513 no 823 0.221330742535566 1100 19798528
SGTC_2925 9010536 32.5 µM 0.766871419576695 0.243751172678967 no 824 0.221578983951845 1090 2994177
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.764184104283865 0.244531540664643 no 825 0.222378768924144 1089 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_3109 9122853 49.47 µM 0.763468108528013 0.244739685093586 no 826 0.222592137385524 1132 1234709
SGTC_1172 0370-0043 85 µM 0.762023700944807 0.245159873520677 no 827 0.223022929358512 1106 376585
SGTC_624 k048-0052 28 µM 0.760728890680361 0.245536872531862 no 828 0.223409507473012 1049 6835531
SGTC_1387 3342-1166 1.8 µM 0.760439460912253 0.245621185930792 no 829 0.223495971632895 1041 3418228
SGTC_1508 1080-0625 72.9 µM 0.759700933348034 0.245836395849758 no 830 0.223716685364731 1048 767111
SGTC_3038 9091290 49.47 µM 0.759561200233098 0.245877126028388 no 831 0.223758459445463 1095 25236843
SGTC_2333 9017922 200 µM 0.759201614844294 0.245981956609907 no 832 0.223865980111729 1109 3163164
SGTC_291 SEC14.278 35.5 µM 0.758337825860743 0.246233876544911 no 833 0.224124384102595 1119 1068044
SGTC_3035 9091303 49.47 µM 0.758061603476608 0.246314464666872 no 834 0.224207052247783 1116 25237002
SGTC_2040 5100729 123 µM 0.75776573167262 0.246400801204986 no 835 0.224295620296391 1088 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_2798 7813637 45.45 µM 0.756531655407123 0.246761084272532 no 836 0.224665250247742 1074 956368
SGTC_2118 5526350 200 µM 0.756285114570975 0.246833094558728 no 837 0.224739135429246 1088 743594
SGTC_1947 st076332 61.6 µM 0.754253293556582 0.247426982226409 no 838 0.225348571057274 1101 24208416
SGTC_2352 9027995 87.8 µM 0.751440963607325 0.248250265800552 no 839 0.226193658839893 1056 2997347
SGTC_2769 toremifene 3.73 µM 0.747624098482674 0.249369950028385 no 840 0.227343462423538 1111 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_984 1492-0255 2.91 µM 0.747255222406337 0.249478302562538 no 841 0.227454757964299 1056 1585198
SGTC_708 3448-5400 146 µM 0.746187720694735 0.249792008170807 no 842 0.227777012370907 1126 3462195
SGTC_1461 k072-0203 53.8 µM 0.745843995785028 0.249893062806873 no 843 0.227880829740164 1101 5418714
SGTC_2487 5918373 44.05 µM 0.745420594466493 0.250017572015889 no 844 0.228008748858548 1173 2876279
SGTC_448 monastrol 171 µM 0.744474172782877 0.250296004289845 no 845 0.22829483025465 1126 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.744206061675377 0.250374911038087 no 846 0.228375910701697 1102 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2245 6637752 200 µM 0.742170660864009 0.250974371789072 no 847 0.228991971068471 1088 681890
SGTC_2216 7189485 200 µM 0.741883002882402 0.251059153255075 no 848 0.229079112440545 1131 731273
SGTC_365 0121-0052 13.6 µM 0.740960335903919 0.251331193199785 no 849 0.229358745088704 1128 3101739
SGTC_218 alverine citrate 93.75 µM 0.740611884540077 0.251433971431139 no 850 0.229464399985885 1082 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_655 k060-0012 42 µM 0.739680461504936 0.251708810350345 no 851 0.229746953180875 1116 5994525
SGTC_222 nsc-310342 10.666 µM 0.739575359956068 0.251739833065371 no 852 0.229778848643375 1086 432556
SGTC_460 trequinsin 123 µM 0.739307902385639 0.25181878734404 no 853 0.229860025926295 1173 5537 A vasodilator.
SGTC_2373 9071805 200 µM 0.738021283032596 0.252198783880176 no 854 0.230250758021274 1141 10149009
SGTC_445 e6 berbamine 66 µM 0.737670078630353 0.252302562843412 no 855 0.230357479425129 1176 6610268 A calcium/calmodulin antagonist.
SGTC_1108 betulinic acid 729.144 nM 0.737546657460976 0.252339038463647 no 856 0.230394990306539 1158 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_811 0416-0114 265 µM 0.735459735196532 0.252956223533024 no 857 0.231029776706019 1148 6612453
SGTC_2151 5563267 85.4165 µM 0.734186047906749 0.253333293002984 no 858 0.231417677819624 1112 5310824
SGTC_617 3770-0098 35 µM 0.733073574384696 0.253662877435767 no 859 0.231756778245977 1096 5962639
SGTC_679 0422-0091 41.4 µM 0.73294559818124 0.253700806451874 no 860 0.231795805267892 1182 627384 YHR062C RPP1
SGTC_2596 sinensetin 100 µM 0.73120811948083 0.254216047186862 no 861 0.232326020733817 1121 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_506 n9-isopropylolomoucine 153 µM 0.730986811804837 0.254281714259502 no 862 0.232393604218655 1144 6610355
SGTC_499 genistein 192 µM 0.730179666290762 0.254521288222521 no 863 0.232640184958881 1154 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2849 9019321 12.99 µM 0.728711495918065 0.254957368148674 no 864 0.23308907962204 1098 16489627
SGTC_529 4076-0302 30.3 µM 0.72728045151781 0.255382796765051 no 865 0.233527085427306 1090 5816522
SGTC_3300 9124615 50.48 µM 0.726555164334438 0.255598555639849 no 866 0.233749251326874 1142 24824903
SGTC_1616 st002734 56.1 µM 0.722707357315146 0.25674479400918 no 867 0.234929847240294 1133 4026101
SGTC_2163 5671233 125 µM 0.722554863077602 0.256790276182217 no 868 0.234976703771905 1190 701023
SGTC_953 1188-0045 9.7 µM 0.722148780033312 0.256911412942568 no 869 0.235101505096264 1154 6144426
SGTC_1546 5-methoxyflavanone 78.7 µM 0.719453799631989 0.257716092943031 no 870 0.235930679310377 1186 147795
SGTC_2480 5767542 37.17 µM 0.718929032495703 0.257872932447886 no 871 0.23609232355976 1166 2867358
SGTC_3099 9120367 49.47 µM 0.718243361875665 0.258077936506988 no 872 0.236303622891632 1196 24824940
SGTC_1151 3909-8316 15.3 µM 0.717785356543405 0.258214919515128 no 873 0.236444821854384 1175 800431
SGTC_2368 9071271 200 µM 0.716780080816646 0.258515715563445 no 874 0.236754902166399 1146 27209959
SGTC_3238 9133470 49.47 µM 0.716747942143831 0.25852533500827 no 875 0.236764819124273 1164 3534688
SGTC_690 glyoxal 20.3 µM 0.716705576360242 0.258538015818809 no 876 0.23677789218773 1088 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_73 0327-0325 16.231 µM 0.716247440916602 0.258675164240885 no 877 0.23691928713761 1200 53298
SGTC_332 4112-0506 40.9 µM 0.716142691798266 0.258706527453968 no 878 0.236951622515514 1160 2790355
SGTC_2364 9055074 200 µM 0.71522613105187 0.258981041294348 no 879 0.237234662367444 1146 6470630
SGTC_1182 1222-0449 220 µM 0.714145455317325 0.259304901703074 no 880 0.237568620407362 1126 658318
SGTC_709 3807-1509 243 µM 0.712369005265853 0.259837728405331 no 881 0.238118151723646 1192 1886677 YPL242C IQG1
SGTC_3204 9114183 49.47 µM 0.711035609689201 0.260238036574943 no 882 0.238531084733407 1187 17027248
SGTC_2210 7115885 190.385 µM 0.710959292481583 0.26026095791837 no 883 0.238554730904845 1183 2927039
SGTC_289 k017-0060 526 µM 0.710246418195167 0.260475114993155 no 884 0.238775670278336 1168 5512909
SGTC_901 1112-0062 60.1 µM 0.709726521835129 0.260631356093648 no 885 0.238936871039432 1198 1908457
SGTC_103 0844-0104 51.839 µM 0.708355995321181 0.261043462664984 no 886 0.239362106030566 1233 5375804
SGTC_1540 guanosine 70.6 µM 0.704775953671398 0.262121531354645 no 887 0.240474837633248 1126 6802 Guanosine is a purine nucleoside
SGTC_2483 5729050 27.16 µM 0.704588484660758 0.262178047263363 no 888 0.240533183382458 1201 2865180
SGTC_2933 9026794 32.47 µM 0.701811051854713 0.263016085244903 no 889 0.241398502772871 1173 17586027
SGTC_2140 5586273 200 µM 0.701470038285748 0.263119073950687 no 890 0.241504863244994 1182 854421
SGTC_542 3381-0244 89.3 µM 0.701030544202729 0.263251834908641 no 891 0.241641976838406 1199 1112843
SGTC_1587 estradiol valerate 56.1 µM 0.700651291855113 0.26336642573136 no 892 0.241760330145147 1192 13791 A steroid.
SGTC_1534 6-azauridine 81.6 µM 0.699871806683773 0.263602026550818 no 893 0.242003682886242 1221 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.699341821436644 0.263762276952949 no 894 0.242169218404601 1193 688798
SGTC_2878 9043973 25.97 µM 0.697442478030349 0.264336984767902 no 895 0.242762962922438 1202 6465167
SGTC_2992 9074591 71.4286 µM 0.696444564528184 0.264639191051524 no 896 0.243075231271381 1194 17741321
SGTC_2023 5144124 124 µM 0.695988688580583 0.264777306136871 no 897 0.243217956798423 1184 2830192
SGTC_809 3998-0021 90 µM 0.695546242620935 0.264911387423705 no 898 0.243356520978368 1134 715485
SGTC_3045 9092950 49.47 µM 0.694429715602861 0.265249899333834 no 899 0.243706381849455 1217 44120432
SGTC_1706 st031321 9.9705 µM 0.693958230915461 0.265392911354421 no 900 0.2438542018692 1219 6103185
SGTC_591 4299-0174 154 µM 0.693605357607226 0.265499971445024 no 901 0.243964866464999 1162 5509088
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.693054557730721 0.265667125299415 no 902 0.244137656949408 1183 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1808 st050063 61.5 µM 0.692396814634148 0.265866803606475 no 903 0.244344082835657 1190 4011993
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.689609972913106 0.266713678745979 no 904 0.245219747037834 1239 279621
SGTC_2071 5230951 39.92 µM 0.688668298689292 0.267000145879677 no 905 0.245516015038788 1255 1799272
SGTC_975 1335-0046 28.5 µM 0.688036169848629 0.267192533202514 no 906 0.245715002197588 1200 16486740
SGTC_1334 1486-0610 236 µM 0.684447317767267 0.268286118745238 no 907 0.246846372680128 1200 3742339
SGTC_3304 9125678 46.087 µM 0.68340320256065 0.268604701078348 no 908 0.247176048456414 1209 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2485 5633444 17.78 µM 0.682932041974953 0.268748524682975 no 909 0.247324892853289 1196 5724239
SGTC_2832 7992762 51.95 µM 0.682644565456827 0.268836297008994 no 910 0.247415733125328 1123 2985177
SGTC_3197 9113331 49.47 µM 0.682614861796178 0.268845366950735 no 911 0.247425120259965 1245 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_829 1635-0120 117 µM 0.682570780159305 0.268858827456375 no 912 0.247439051562448 1228 285054
SGTC_3155 9099265 49.47 µM 0.682485880162995 0.268884752966284 no 913 0.247465884041421 1170 25236499
SGTC_3122 9126309 49.47 µM 0.682459915144482 0.268892682031708 no 914 0.247474090545572 1262 17591206
SGTC_1222 0366-0074 1.18 µM 0.682177064255181 0.268979065204033 no 915 0.247563497821956 1245 286520
SGTC_3135 9127742 49.47 µM 0.682127787216553 0.26899411592536 no 916 0.247579075729468 1193 3643468
SGTC_313 3474-0040 5.03 µM 0.680537497985382 0.269480065956193 no 917 0.248082093505987 1201 1043375 YIL048W NEO1
SGTC_320 4092-0846 5.34 µM 0.678875985969011 0.269988249353198 no 918 0.248608221278825 1195 1359356
SGTC_525 k781-2675 26.7 µM 0.677808460180327 0.270315011367801 no 919 0.2489465731044 1260 3651118 YDL195W SEC31
SGTC_1089 terbinafine 2.25 µM 0.677182645307001 0.270506660709107 no 920 0.24914503873585 1209 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_2226 7298446 200 µM 0.674490759476595 0.27133179620579 no 921 0.249999679274407 1225 3283010
SGTC_2883 9059145 45.46 µM 0.674140301724623 0.271439313152979 no 922 0.250111059623159 1227 16476510
SGTC_2877 9040724 71.43 µM 0.673937573672776 0.271501517788463 no 923 0.250175501433796 1228 6463895
SGTC_400 oxethazaine 37.5 µM 0.673646409910828 0.271590870265597 no 924 0.250268069988827 1210 4621 A local anesthetic.
SGTC_635 k038-0028 24.7 µM 0.673615593165982 0.271600328180122 no 925 0.250277868498596 1253 4035102
SGTC_1323 1348-1351 11.2 µM 0.672499169108465 0.27194307853443 no 926 0.250632984453565 1188 6989654
SGTC_784 4579-0127 173 µM 0.670803575698888 0.272464049298502 no 927 0.251172834641171 1294 1948547
SGTC_2279 7948423 32.93 µM 0.670411672991946 0.272584531810671 no 928 0.251297697721896 1247 1247112
SGTC_1999 st074831 12.5 µM 0.669998191233223 0.272711677028365 no 929 0.251429471616806 1223 17112523
SGTC_1594 piperine 70.1 µM 0.669565925372931 0.272844629794751 no 930 0.251567270916426 1234 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1395 3486-0190 4.35 µM 0.669521632264668 0.272858254919218 no 931 0.251581393089578 1269 6748079
SGTC_3325 9138760 55.175 µM 0.669199029067542 0.272957501951908 no 932 0.251684262766491 1224 43844959
SGTC_1114 scopoletin 1.73284 µM 0.668667100623216 0.273121185780933 no 933 0.251853929261272 1251 5280460 A coumarin with genotoxic properties.
SGTC_2712 st079126 47.7 µM 0.668183580994678 0.273270015550582 no 934 0.252008207413131 1212 3152970
SGTC_2320 7373003 200 µM 0.668011621225664 0.273322955313449 no 935 0.252063087184214 1238 5415828
SGTC_737 1950-0117 57.9 µM 0.66593406656438 0.273962955152341 no 936 0.252726622326366 1208 5393513
SGTC_1666 st014829 29 µM 0.665489473985561 0.274100010002183 no 937 0.252868736914552 1256 3858230
SGTC_946 3434-1334 87.4 µM 0.660056647064943 0.275777522071564 no 938 0.254608739018385 1220 4047976
SGTC_1643 st009866 20.2 µM 0.658669607820406 0.276206609871583 no 939 0.255053976705995 1249 3156273 YOR207C RET1
SGTC_843 0310-0051 143 µM 0.65865358502587 0.276211568520046 no 940 0.255059122379597 1252 2065037
SGTC_2640 pentamidine 10.38 µM 0.658199940422617 0.27635197814285 no 941 0.255204831548359 1271 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_104 0074-0074 590.992 µM 0.657714053933564 0.27650240592292 no 942 0.255360944967859 1127 3943124
SGTC_3051 9093778 49.47 µM 0.657395915764805 0.276600921491601 no 943 0.255463188543877 1273 17217378
SGTC_1189 1431-2119 7.28 µM 0.65699573330931 0.276724867553618 no 944 0.255591829967097 1276 3107275
SGTC_2728 chlorpromazine 9.18 µM 0.656889486027472 0.276757779444675 no 945 0.255625989575153 1266 2726 A thorazine and dopamine antagonist.
SGTC_735 3076-0345 636 µM 0.654791806804323 0.277407963423851 no 946 0.256300903231614 1299 2888990
SGTC_52 0329-0193 875 nM 0.654508928887541 0.27749569966154 no 947 0.256391988249053 1327 3739292
SGTC_2754 granisetron 64.02 µM 0.654119533528867 0.277616495084905 no 948 0.256517398839793 1269 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_600 1495-0418 41.6 µM 0.653549875993797 0.277793256410098 no 949 0.256700923108462 1272 5377768
SGTC_423 5-fluorouracil 457 µM 0.653461605313631 0.27782065119066 no 950 0.256729367033159 1234 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2478 5763493 32.33 µM 0.650966991117552 0.278595398888273 no 951 0.257533897581704 1235 1365576 YLR208W SEC13
SGTC_1707 st032323 6.317 µM 0.648181875975632 0.27946160815789 no 952 0.25843366139815 1210 3132057 YMR211W DML1
SGTC_2154 5570129 200 µM 0.640277101918464 0.281927202275954 no 953 0.260996232303763 1288 673366
SGTC_832 4083-0019 164 µM 0.638925361321224 0.282349873343947 no 954 0.261435744262363 1367 1990758
SGTC_618 k072-0232 33.2 µM 0.637991056114776 0.282642196052686 no 955 0.261739751090295 1280 5872756 YGL099W LSG1
SGTC_1476 4112-3294 3.34 µM 0.63584132789 0.28331534863179 no 956 0.262439923735462 1333 704369
SGTC_771 0250-0039 27.3 µM 0.635583116979643 0.283396254886308 no 957 0.262524088232608 1291 3005115
SGTC_1449 4112-4002 201 µM 0.635227277974692 0.283507769488216 no 958 0.262640097488076 1239 2059539
SGTC_343 4130-2827 29.8 µM 0.63518865187977 0.283519875591601 no 959 0.262652691796124 1294 1118244
SGTC_1064 honokiol 6.76 µM 0.635006994080694 0.283576813690436 no 960 0.26271192673408 1281 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1285 0929-0069 65.5 µM 0.634662299263512 0.283684868522901 no 961 0.262824343533486 1295 1206237
SGTC_1847 st056231 15 µM 0.634425747584936 0.283759034083913 no 962 0.262901505378918 1305 5393180
SGTC_1567 st069303 68.4 µM 0.633702405123902 0.283985879742154 no 963 0.26313752751652 1326 5581319
SGTC_248 streptozotocin 5.23457 mM 0.633701421731038 0.283986188200637 no 964 0.263137848465159 1323 5300 DNA alkylating agent.
SGTC_905 2-aminofluorene 215 µM 0.632609543001754 0.284328774049526 no 965 0.263494326848055 1309 1539 An established DNA mutagen. YPR165W RHO1
SGTC_647 0140-0236 81 µM 0.631800303636549 0.2845828068706 no 966 0.263758687603717 1296 990837
SGTC_187 1488-2104 32.728 µM 0.631468573947457 0.284686973290232 no 967 0.263867095494516 1323 2852859
SGTC_2962 9082311 13.18 µM 0.629859995496763 0.285192340854067 no 968 0.264393094225376 1275 16459453
SGTC_1078 idebenone 36.1 µM 0.629204306229412 0.285398461523664 no 969 0.264607655012998 1304 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_1919 st067113 52.3 µM 0.62713002084379 0.286050994950885 no 970 0.265287004936771 1308 1268243
SGTC_1201 1889-3372 45.9 µM 0.624542396214819 0.286866008254175 no 971 0.266135718221022 1241 5392199
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.623964030721726 0.287048323964338 no 972 0.266325603753667 1303 4330530
SGTC_1640 st009078 66.4 µM 0.622408430031676 0.287538961484172 no 973 0.26683666933038 1340 690618
SGTC_458 nppb 133 µM 0.622071416687607 0.287645307954166 no 974 0.266947454479154 1382 4549 A chloride channel blocker.
SGTC_714 4296-0578 26.1 µM 0.621639399561766 0.287781660587892 no 975 0.267089503841355 1305 1589775
SGTC_204 PMA1.184 62.41 µM 0.621397457972455 0.287858035185586 no 976 0.267169072097184 1322 2252213 YGL008C PMA1
SGTC_2438 5259590 200 µM 0.620159405124755 0.288249005661119 no 977 0.2675764224518 1311 1201127
SGTC_1057 3448-5381 134 µM 0.619797905864118 0.28836321242035 no 978 0.267695423784611 1336 5497911
SGTC_569 4130-2812 160 µM 0.619750754538687 0.288378110289217 no 979 0.267710947416117 1249 743552
SGTC_1275 0867-0008 21.1 µM 0.618570684614014 0.288751081710724 no 980 0.268099609546426 1312 3422836
SGTC_2303 7774051 200 µM 0.617696794964642 0.289027428470543 no 981 0.268387612546033 1354 2953184
SGTC_876 0720-0963 56.8 µM 0.614394947094552 0.290072680543202 no 982 0.269477186987913 1408 765861
SGTC_1264 0783-0040 158 µM 0.612211767850302 0.29076477199801 no 983 0.270198828360106 1287 2855798
SGTC_1302 1159-0335 255 µM 0.611949321134838 0.290848022409496 no 984 0.270285644126117 1323 649284
SGTC_476 mead acid 10 µM 0.611590963091597 0.290961714730292 no 985 0.270404209290218 1351 5312531 An omega 9 fatty acid.
SGTC_1953 st076800 12.1 µM 0.611445947407817 0.291007728165047 no 986 0.270452196089411 1288 297591
SGTC_2145 5634607 200 µM 0.608126041142612 0.29206206204151 no 987 0.271551940994085 1291 308662
SGTC_1519 esterone 74 µM 0.60672031720402 0.292509026233445 no 988 0.272018268254583 1279 698 A steroid.
SGTC_160 3453-0671 289.699 µM 0.605187919898495 0.292996629361442 no 989 0.272527070722496 1275 5322268
SGTC_2423 st077119 87.2 µM 0.604265499815096 0.293290321711917 no 990 0.272833569874664 1285 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_1525 8-methoxypsoralen 92.5 µM 0.60423578873457 0.293299783787955 no 991 0.272843445030625 1380 4114 Related to psoralen; DNA damaging agent.
SGTC_1209 2323-2347 50.3 µM 0.603810991677936 0.293435084207826 no 992 0.272984655416278 1318 5412760
SGTC_2687 chenodiol 100 µM 0.603800055694399 0.293438567766147 no 993 0.2729882912175 1365 5702181 A cholesterol synthesis inhibitor.
SGTC_656 4090-1979 187 µM 0.60321854100794 0.293623831580234 no 994 0.273181657446238 1353 22330961
SGTC_1725 st036284 20.55 µM 0.602727439746042 0.293780332891529 no 995 0.273345012093835 1389 707914
SGTC_2724 maprotiline 69.64 µM 0.600185120231367 0.294591120950167 no 996 0.274191434560547 1335 4011 A tricyclic antidepressant.
SGTC_2508 celastrol 40.54 µM 0.600037519612295 0.294638224939301 no 997 0.274240615432894 1284 122724 Celastrol is a natural product and antioxidant.
SGTC_2873 9040596 71.43 µM 0.599783381090243 0.29471933665629 no 998 0.27432530519074 1334 6463863
SGTC_1184 1269-1718 139 µM 0.598103631226782 0.295255710119787 no 999 0.274885393742928 1410 5403821
SGTC_1601 4'-hydroxyflavanone 55.5 µM 0.597870001568839 0.295330347727674 no 1000 0.274963338828865 1428 165506
SGTC_1428 4049-0204 61.7 µM 0.597439535422154 0.295467891369673 no 1001 0.275106982328681 1407 X1428
SGTC_2166 5933061 31.504 µM 0.597380416946842 0.295486783356543 no 1002 0.275126712630424 1514 2877375
SGTC_627 1391-0720 175 µM 0.597248584064758 0.295528914066685 no 1003 0.275170713272908 1317 997839
SGTC_158 k038-0087 26.446 µM 0.596973973503391 0.295616682056823 no 1004 0.275262378625969 1293 X158
SGTC_3012 9080433 71.4286 µM 0.596573655467 0.295744648740288 no 1005 0.27539603221442 1352 17688859
SGTC_352 k048-0007 5.11 µM 0.593583970962396 0.296701142714563 no 1006 0.276395202253293 1319 6811911
SGTC_2969 9091408 28.7 µM 0.59296648497634 0.296898872237807 no 1007 0.276601790999137 1320 4286311
SGTC_1406 3909-7906 11.9 µM 0.592066508212353 0.297187168049103 no 1008 0.276903026541268 1359 X1406
SGTC_35 0133-0054 64.071 µM 0.591926352014474 0.297232076771465 no 1009 0.276949953347773 1280 99677
SGTC_2293 7624732 200 µM 0.59074546314138 0.297610579210159 no 1010 0.27734549063734 1299 894453
SGTC_2404 5161160 200 µM 0.588519303754861 0.298324712820232 no 1011 0.278091890368813 1340 2831543
SGTC_2806 7952793 58.44 µM 0.586583035385061 0.29894648536145 no 1012 0.278741889518732 1399 2972490
SGTC_701 4424-0219 185 µM 0.586178409713027 0.299076492665971 no 1013 0.278877814436704 1389 2911779
SGTC_1960 st011366 51.8 µM 0.586081307549416 0.299107695668015 no 1014 0.278910438528197 1357 3972846
SGTC_1453 4237-0541 195 µM 0.585427628806314 0.299317788541396 no 1015 0.279130107846925 1342 739892
SGTC_2232 chlorophetanol 41.5365 µM 0.584833394493494 0.29950883398932 no 1016 0.279329873772079 1418 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_2794 7785382 27.27 µM 0.584443949836549 0.299634069841715 no 1017 0.279460832476742 1344 2205081
SGTC_2208 7283366 200 µM 0.58369014343456 0.299876542877058 no 1018 0.279714399927978 1396 898663
SGTC_125 0133-0007 11.75 µM 0.583550769186522 0.29992138440368 no 1019 0.279761295243805 1434 26541
SGTC_759 3486-0358 89.3 µM 0.582441242360596 0.300278465832431 no 1020 0.280134754227339 1395 875103
SGTC_564 3555-0129 330 µM 0.582324810239101 0.300315948573292 no 1021 0.280173958468226 1293 563260
SGTC_2104 5389443 200 µM 0.580930750560326 0.3007648993159 no 1022 0.280643563215347 1451 2244536
SGTC_2467 5474540 200 µM 0.580313715269337 0.300963709430943 no 1023 0.28085154002628 1329 5413519
SGTC_1389 3405-0187 19 µM 0.5791034709411 0.30135382476387 no 1024 0.281259679083227 1315 799890
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 0.578973532488054 0.301395723211234 no 1025 0.281303516143007 1394 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2793 7325131 81.82 µM 0.574155965846377 0.302950986932357 no 1026 0.282931132066789 1401 4176441
SGTC_2537 larixol 68.93 µM 0.57328048484703 0.303234005296401 no 1027 0.283227398331578 1360 6708759
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.573083365900189 0.303297744603974 no 1028 0.283294124689327 1428 688664
SGTC_1516 st013856 110 µM 0.570354328536002 0.304180805875208 no 1029 0.284218699760938 1361 5281404 A mutagen and neurotoxin.
SGTC_1297 1068-0111 14.1 µM 0.568335747290607 0.304834713926489 no 1030 0.284903505123621 1332 767057
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.567437127503796 0.305126017578178 no 1031 0.285208615608678 1431 364106
SGTC_2961 9083290 32.55 µM 0.566487222702861 0.305434080466428 no 1032 0.285531308205463 1416 17741490
SGTC_2009 4012297 12.05 µM 0.566192748131603 0.305529609282198 no 1033 0.285631379575189 1382 45595307
SGTC_2442 5158906 48.48 µM 0.566120220510201 0.305553139586534 no 1034 0.285656029216731 1474 1893835
SGTC_2316 5844804 197.44 µM 0.565913401674806 0.305620242710978 no 1035 0.285726325376366 1425 776813
SGTC_213 1246-0773 967 nM 0.564069431327623 0.306218814003002 no 1036 0.286353440443076 1399 6251622
SGTC_1963 st076565 50.3 µM 0.562081993989683 0.306864535782313 no 1037 0.287030077851231 1406 4914280
SGTC_1617 st002906 78 µM 0.561667988760742 0.306999122324774 no 1038 0.287171124166423 1389 5150859
SGTC_3353 9151644 39.2805 µM 0.560528220793297 0.307369777173261 no 1039 0.287559598021895 1385 4909158
SGTC_1733 st037357 54.9 µM 0.560416994059927 0.30740595887872 no 1040 0.287597521388511 1332 1272339 YGL099W LSG1
SGTC_2996 9066192 71.4286 µM 0.559961953441448 0.307554001672195 no 1041 0.287752694605821 1344 6472854
SGTC_2458 5808907 16.39 µM 0.559497761939619 0.307705053913936 no 1042 0.287911029106868 1416 2731747
SGTC_936 3005-4620 401 µM 0.5592405523467 0.307788766352251 no 1043 0.287998780332283 1488 777207
SGTC_107 0358-0022 2.6945 µM 0.558717910416512 0.307958898256234 no 1044 0.288177126986519 1451 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_303 1348-1668 34.2 µM 0.557766986334476 0.308268551674039 no 1045 0.288501754481284 1410 5380509
SGTC_1047 2043-3044 82 µM 0.556961126477078 0.30853107407418 no 1046 0.288776994622018 1357 669592
SGTC_1655 st012546 55.1 µM 0.556200619221779 0.30877891191022 no 1047 0.289036857985543 1365 720985 YLR208W SEC13
SGTC_2561 acetosyringone 100 µM 0.555405044405902 0.309038270965855 no 1048 0.289308821507505 1374 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_3169 9102970 49.47 µM 0.555150910341735 0.309121139275879 no 1049 0.289395721382025 1446 17027839
SGTC_1010 4112-3296 15.2 µM 0.554649556420643 0.309284649783769 no 1050 0.289567192802122 1448 704384
SGTC_2683 piperine 63.03 µM 0.552069938510153 0.310126557587433 no 1051 0.290450218532239 1373 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_845 0330-0138 4.51 µM 0.551983648366451 0.31015473727629 no 1052 0.290479778176399 1438 9039800
SGTC_1573 oleylamine 1.06 µM 0.551548660845326 0.310296807703966 no 1053 0.290628809403259 1410 5356789 An amine of the fatty acid oleic acid.
SGTC_1613 st002381 52.1 µM 0.55087068948212 0.310518295061252 no 1054 0.29086116070322 1391 551167
SGTC_2593 nobiletin 86.24 µM 0.549574297556211 0.310942006314544 no 1055 0.291305695913455 1362 72344 An anti-infammatory.
SGTC_2370 9071495 200 µM 0.544537002067169 0.312590766448461 no 1056 0.293035996447776 1378 21791103
SGTC_1412 3909-8563 178 µM 0.544450585816655 0.31261908427863 no 1057 0.293065721805101 1497 23767530
SGTC_1433 4060-0023 7.6 µM 0.543478773394622 0.312937614630212 no 1058 0.293400100931147 1442 3840627
SGTC_3047 9092122 49.47 µM 0.541618683969822 0.313547684419492 no 1059 0.294040608953866 1378 17173831
SGTC_1203 3992-3522 103 µM 0.540414570740671 0.313942880208706 no 1060 0.294455580765487 1655 5322312
SGTC_711 k292-0785 179 µM 0.53856764466273 0.314549465086469 no 1061 0.295092609010338 1403 4146315
SGTC_1261 0712-0010 12.7 µM 0.538314941469914 0.314632499245642 no 1062 0.295179818888048 1504 2840123
SGTC_2323 6148992 148.28 µM 0.538105368498711 0.314701368627403 no 1063 0.29525215318379 1394 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_721 1187-1332 279 µM 0.536585345429274 0.315201067876119 no 1064 0.295777034500163 1368 25730
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.535324787390518 0.315615726096644 no 1065 0.296212644476276 1406 2374 Ca(2+)-ATPase inhibitor.
SGTC_1325 1431-0015 227 µM 0.535141532178524 0.31567602690492 no 1066 0.296275996318122 1344 1103340
SGTC_2432 5630864 12.22 µM 0.534312645147242 0.315948836539648 no 1067 0.296562622479036 1406 5714970
SGTC_110 0850-0284 111.64 µM 0.533083039649774 0.316353718369751 no 1068 0.296988049487961 1324 3906265
SGTC_533 1222-0222 6.71 µM 0.531248288157019 0.316958270771148 no 1069 0.297623367413896 1531 3982874
SGTC_1796 st049173 110.4 µM 0.530837392496026 0.317093728366391 no 1070 0.297765732890311 1403 94134
SGTC_384 k007-0144 5.16 µM 0.530749490642998 0.317122709645202 no 1071 0.297796192803983 1463 6824886
SGTC_413 propylparaben 100 µM 0.53070157697047 0.317138507276035 no 1072 0.297812796537377 1385 7175 A pharmaceutical preservative.
SGTC_995 3931-2021 34.6 µM 0.529712844085298 0.31746457703967 no 1073 0.298155520655723 1479 730143
SGTC_2059 5238311 157 µM 0.528962577109827 0.317712098773086 no 1074 0.298415705249317 1410 703021
SGTC_599 1935-0052 86.5 µM 0.526487957643901 0.318529081494318 no 1075 0.299274608440183 1420 9557311
SGTC_570 0987-0065 62.6 µM 0.526342821934777 0.318577024745957 no 1076 0.299325017661176 1373 3104428
SGTC_2330 7979373 200 µM 0.523283255691972 0.319588409261602 no 1077 0.300388575752059 1355 1863007
SGTC_1013 4112-3890 241 µM 0.52236457305134 0.319892355862596 no 1078 0.300708258710578 1403 705171
SGTC_2942 9052777 62.25 µM 0.521378810624424 0.320218630376485 no 1079 0.301051454735517 1512 6469503
SGTC_3343 9148379 18.9835 µM 0.518093559924715 0.321307008354963 no 1080 0.302196496661544 1577 1955036
SGTC_1560 lithocholic acid 53.1 µM 0.516323378499281 0.321894093262799 no 1081 0.302814285300875 1446 9903 A bile acid which acts as a detergent.
SGTC_489 paxilline 115 µM 0.513715308857556 0.322759876094571 no 1082 0.303725523581231 1403 105008 A toxic potassium channel blocker.
SGTC_1539 benzyladenosine 56 µM 0.513089315570801 0.322967826037576 no 1083 0.303944422515225 1438 92208 A nucleotide analog.
SGTC_2563 tomatine 8.54 µM 0.512575736978001 0.323138474061526 no 1084 0.30412406450588 1577 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_144 4161-2749 112.381 µM 0.511920415201057 0.323356273497399 no 1085 0.304353354782739 1376 797501 YMR168C CEP3
SGTC_17 0960-0276 49.807 µM 0.511557543584631 0.323476901726606 no 1086 0.304480352888259 1461 6821114
SGTC_609 0986-0026 86.3 µM 0.511530379400668 0.323485932574418 no 1087 0.304489860780292 1500 2848610
SGTC_2546 rhodinyl acetate 100 µM 0.511281212069207 0.323568774157732 no 1088 0.304577079432158 1494 6708682
SGTC_2284 7945075 39.21 µM 0.509024687605479 0.324319406963224 no 1089 0.305367459836771 1569 1245402
SGTC_29 0299-0004 12.984 µM 0.508420373098207 0.324520553593967 no 1090 0.305579284086236 1400 16871 A napthoquinone isolated from Swertia calycina.
SGTC_193 1273-0060 1.558 µM 0.508184904275784 0.324598943470037 no 1091 0.305661838215845 1401 2847393 YHR072W ERG7
SGTC_226 1,3-diallylurea 8.28947 mM 0.507996402428268 0.324661703181092 no 1092 0.305727933091364 1457 74537 YKL182W FAS1
SGTC_1875 nocodazole 6 µM 0.507080964250852 0.324966559481693 no 1093 0.306049005450758 1481 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1968 st069590 43.6 µM 0.503984522346148 0.325998594652821 no 1094 0.307136126727158 1505 6384066
SGTC_1657 st012939 43.4 µM 0.503032604636616 0.326316134620653 no 1095 0.307470674468322 1522 24207257
SGTC_689 0833-0039 98 µM 0.501905403024988 0.32669230850313 no 1096 0.307867032240179 1520 5374726
SGTC_2710 st078562 53.7235 µM 0.501037169964374 0.326982178635965 no 1097 0.30817248187371 1421 17250908
SGTC_3057 9095946 49.47 µM 0.501003773533196 0.326993330525995 no 1098 0.308184233595363 1502 24540043
SGTC_1895 st058434 18.3 µM 0.500734575667365 0.327083227957686 no 1099 0.308278967614798 1561 5393175
SGTC_2802 7925815 54.55 µM 0.500371788114894 0.327204395121715 no 1100 0.308406657190272 1452 1262923
SGTC_3340 9146634 11.102 µM 0.500070544694268 0.327305021044396 no 1101 0.308512702823182 1478 4907387
SGTC_660 4031-1742 102 µM 0.499731803782021 0.327418187442904 no 1102 0.308631967645203 1469 6738706
SGTC_874 0599-0792 117 µM 0.498607978972018 0.327793747840934 no 1103 0.309027791496515 1594 765305
SGTC_719 2810-4230 27.3 µM 0.49735737294295 0.328211880898557 no 1104 0.309468529931297 1505 721079
SGTC_3019 9081971 49.47 µM 0.496007778073581 0.328663351889514 no 1105 0.309944461627636 1594 16451803
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.495902310522849 0.328698643795825 no 1106 0.309981667964518 1663 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_871 0574-0004 149 µM 0.495001737467566 0.329000058772492 no 1107 0.310299447029162 1496 9551173
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.494967224850557 0.329011612097919 no 1108 0.310311628080997 1484 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_3102 9121669 49.47 µM 0.493902420805764 0.32936814246896 no 1109 0.310687547421261 1533 41905072
SGTC_1531 st059297 52.4 µM 0.492958753645296 0.329684242081807 no 1110 0.311020865786907 1504 7566702
SGTC_2845 9003024 42.97 µM 0.491707261662835 0.330103641291184 no 1111 0.311463152005838 1565 2990173
SGTC_1310 1188-0297 994 nM 0.491398389207819 0.330207183317755 no 1112 0.311572351649315 1477 1588352
SGTC_1608 st001473 40.5 µM 0.491046772327179 0.330325070208241 no 1113 0.311696683452805 1440 7292267
SGTC_993 3909-8757 62.7 µM 0.490049646651787 0.330659468953654 no 1114 0.312049384031498 1509 4288324 YLR208W SEC13
SGTC_1501 4491-0275 38.4 µM 0.489406992659432 0.330875062796446 no 1115 0.31227679322404 1502 5104718
SGTC_1900 st060200 72.8 µM 0.486886231482045 0.331721254239409 no 1116 0.31316947833296 1500 688945
SGTC_549 1661-1316 519 µM 0.486743171159713 0.331769303804524 no 1117 0.313220173651266 1585 2857282
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 0.486477176001124 0.331858650759022 no 1118 0.313314441939004 1744 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_1649 st011737 51.3 µM 0.486008633150686 0.332016056116539 no 1119 0.313480522493588 1472 1761035
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.483660422773832 0.332805375485387 no 1120 0.314313442666344 1410 641818 YHR062C RPP1
SGTC_1929 genistein trimethyl ether 50.5 µM 0.482816592124075 0.33308919913262 no 1121 0.314612984336124 1658 136420
SGTC_1131 3454-3128 32.3 µM 0.482031396013495 0.333353386871023 no 1122 0.314891821648236 1601 710982
SGTC_1884 5633444 25 µM 0.481937496807134 0.33338498581443 no 1123 0.314925174020342 1527 5724239
SGTC_3085 9117376 49.47 µM 0.481338418713803 0.333586615291203 no 1124 0.315137998089196 1565 16480349
SGTC_3237 9133362 49.47 µM 0.480059546231903 0.334017201431686 no 1125 0.315592526196392 1561 43845137
SGTC_2 0422-0095 29 µM 0.478572006797987 0.3345183190563 no 1126 0.316121568414592 1424 6790840
SGTC_2591 skatole 100 µM 0.478571090407321 0.334518627858117 no 1127 0.316121894444418 1518 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_550 4123-0385 25.7 µM 0.478293562441968 0.334612153319046 no 1128 0.316220638817725 1483 5731123
SGTC_603 3794-0023 45.9 µM 0.477707134605897 0.334809810156265 no 1129 0.316429332785116 1600 3802260
SGTC_2035 5154463 94.595 µM 0.476902332167566 0.335081145159642 no 1130 0.316715835602749 1571 2769623
SGTC_3136 9095672 49.47 µM 0.476170958897676 0.335327798568237 no 1131 0.316976293655117 1519 17217380
SGTC_695 3505-6186 243 µM 0.475620914534345 0.335513346142352 no 1132 0.317172236286885 1563 1819379
SGTC_463 ikarugamyin 104 µM 0.47505005841854 0.335705956615025 no 1133 0.317375646915197 1559 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1344 1488-0097 29.1 µM 0.474938775980844 0.335743509044713 no 1134 0.317415306119961 1534 747966
SGTC_1365 1672-3266 55.4 µM 0.474557766394946 0.335872093735336 no 1135 0.317551107453678 1576 6415873
SGTC_2920 7982904 15.77 µM 0.473782193309153 0.336133896699711 no 1136 0.317827616927596 1475 6456808
SGTC_2835 9006588 71.43 µM 0.473107764325039 0.336361622028968 no 1137 0.318068148837318 1504 2345538
SGTC_301 4119-0100 24.5 µM 0.472913507853457 0.336427225131195 no 1138 0.318137443732375 1543 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_887 0885-0007 9.62 µM 0.471384033757087 0.336943923555228 no 1139 0.318683257802914 1598 5719458
SGTC_145 3737-0113 38.366 µM 0.470331177602251 0.337299786290279 no 1140 0.319059212964863 1592 6849351
SGTC_678 1218-2179 85.9 µM 0.469323609386055 0.337640478171037 no 1141 0.319419171031789 1551 6820081 YOR116C RPO31
SGTC_47 0149-0135 24.25 µM 0.468757611688589 0.337831918972578 no 1142 0.319621450838232 1412 5239155
SGTC_2772 vinpocetine 57.06 µM 0.468497750322883 0.337919827501129 no 1143 0.319714339704561 1577 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_2271 7849410 118.62 µM 0.467872477723405 0.338131387255125 no 1144 0.319937893150546 1558 972430
SGTC_3134 9127454 49.47 µM 0.467848461384844 0.338139514155999 no 1145 0.319946481006693 1577 24262820
SGTC_2159 5658611 73.75 µM 0.467801332149869 0.338155462460734 no 1146 0.319963333943087 1536 793844
SGTC_2903 5923464 63.88 µM 0.467511373227094 0.338253589544229 no 1147 0.320067028486957 1543 2876576
SGTC_1319 1306-0155 43.7 µM 0.466306490610528 0.338661460155077 no 1148 0.320498066753516 1558 3122360
SGTC_3348 9149464 3.537 µM 0.464389602009742 0.339310745317283 no 1149 0.321184319211706 1511 1951442
SGTC_2014 4013930 200 µM 0.460297548191456 0.340698393990859 no 1150 0.322651330402656 1517 64556
SGTC_951 1171-0579 82.7 µM 0.459762507965563 0.340879990448708 no 1151 0.322843348490802 1461 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_723 4182-0001 115 µM 0.45933672213122 0.341024531541414 no 1152 0.322996190538487 1513 744821 YLR208W SEC13
SGTC_322 k048-0136 19.3 µM 0.459299694179809 0.34103710248635 no 1153 0.323009483676052 1524 6823282
SGTC_95 0471-0001 561.058 µM 0.459000330835786 0.341138742460922 no 1154 0.323116964250658 1457 4015405
SGTC_31 0508-1974 57.237 µM 0.458447191249519 0.341326574981631 no 1155 0.32331559709123 1583 6810525
SGTC_651 3253-0966 34.4 µM 0.457991210845318 0.341481444213639 no 1156 0.323479377879562 1516 781462
SGTC_2706 st078239 82.5 µM 0.455704126323139 0.342258632113834 no 1157 0.324301377184264 1528 15434492
SGTC_1659 st012954 42.1 µM 0.454087510801077 0.34280838746826 no 1158 0.324882921010389 1568 24207262
SGTC_2305 7443522 69.23 µM 0.453730452489491 0.342929855664677 no 1159 0.325011422935674 1613 5415886
SGTC_996 3970-0799 1.8 µM 0.45296031122157 0.343191906428807 no 1160 0.325288660394875 1625 6615648 YGL040C HEM2
SGTC_539 4859-0462 2.54 µM 0.452302643321343 0.343415746351416 no 1161 0.325525485974294 1660 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2265 7929201 200 µM 0.452111006483355 0.343480981061032 no 1162 0.325594507475758 1479 1265108
SGTC_2452 5863136 48.41 µM 0.451557806182126 0.343669321010745 no 1163 0.325793786193321 1507 2184096
SGTC_706 4262-0057 46.9 µM 0.448973349337845 0.344549726476004 no 1164 0.326725440980689 1514 883298
SGTC_666 0272-0154 136 µM 0.447182949713808 0.345160127673775 no 1165 0.327371485536712 1563 6870312
SGTC_2913 7966556 36.57 µM 0.446849869323181 0.345273729332765 no 1166 0.327491730798121 1637 2976516
SGTC_1721 st082152 9.2685 µM 0.445547408384713 0.345718085360985 no 1167 0.327962103602477 1498 5296051
SGTC_2050 5263056 171 µM 0.44493816450065 0.345926011990034 no 1168 0.328182220671984 1663 763468 YGL055W OLE1
SGTC_265 mycophenolic acid 32.932 µM 0.444099234862082 0.346212403277513 no 1169 0.328485419820544 1613 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_210 3551-0445 56.827 µM 0.444036993073903 0.346233654700032 no 1170 0.328507919247305 1591 2865180 YOR207C RET1
SGTC_75 0159-0059 199.013 µM 0.443962000165207 0.346259260423512 no 1171 0.328535028829406 1657 5377270
SGTC_2855 9016525 58.44 µM 0.441404449337262 0.347132935496219 no 1172 0.329460110846422 1531 43811474
SGTC_282 k297-0036 65.7 µM 0.439685167590418 0.347720710052894 no 1173 0.330082573353512 1601 5061378
SGTC_515 4092-1064 102 µM 0.438666318509023 0.348069199092706 no 1174 0.330451667843941 1700 717353
SGTC_1161 k007-0610 110 µM 0.438589258604375 0.348095562030621 no 1175 0.33047959075118 1609 5843850
SGTC_640 3381-0960 37.1 µM 0.438564676140141 0.348103972083603 no 1176 0.330488498485654 1648 1745025
SGTC_371 0195-0006 7.36 µM 0.43623747117361 0.348900483790888 no 1177 0.331332221852097 1492 3928593
SGTC_130 0136-0219 337.655 µM 0.435986969730196 0.348986260469799 no 1178 0.331423091788415 1642 234244
SGTC_986 1493-0483 84 µM 0.435833938482707 0.34903866521162 no 1179 0.331478609085784 1627 40079
SGTC_1698 5-fluorocytosine 1.055 µM 0.435092717432534 0.349292533172427 no 1180 0.331747564652746 1664 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_3015 9080845 49.47 µM 0.434075846041449 0.34964092099425 no 1181 0.332116682370631 1688 5296973
SGTC_574 1315-0397 40 µM 0.433695601186026 0.34977122830931 no 1182 0.332254750665475 1554 6794277
SGTC_2223 6903751 107.57 µM 0.432634283588044 0.350135028200313 no 1183 0.332640239383664 1614 5598863
SGTC_2275 7947463 200 µM 0.431206819534257 0.350624553188211 no 1184 0.33315899789369 1570 1225414
SGTC_177 1327-0068 8.361 µM 0.430030057039712 0.351028290903897 no 1185 0.333586888511975 1547 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1862 st057513 3.81 µM 0.429942529411587 0.351058327654073 no 1186 0.333618723688355 1570 5393163
SGTC_1660 st012960 28.1 µM 0.427377812799403 0.351938870783756 no 1187 0.334552082533176 1576 24207266
SGTC_2705 st078069 42.8 µM 0.426348785206377 0.352292390066938 no 1188 0.334926857157521 1559 1530061
SGTC_1473 k844-0725 134 µM 0.425725671720522 0.352506520877843 no 1189 0.335153876734512 1638 54682906
SGTC_2552 juarezic acid 87.02 µM 0.424862016523351 0.352803390316352 no 1190 0.335468632700117 1587 1549512
SGTC_278 4092-0821 23.9 µM 0.424458354780765 0.352942174168373 no 1191 0.335615785364489 1628 877900
SGTC_2276 7947513 42.08 µM 0.423432552783727 0.353294945470227 no 1192 0.335989849242145 1446 2105100
SGTC_2340 7987427 183.45 µM 0.422872840657246 0.353487482565189 no 1193 0.336194019643393 1617 2239331
SGTC_3010 9080089 71.4286 µM 0.419085313743375 0.354791348713272 no 1194 0.337576891732019 1686 17027233
SGTC_2568 diosmetin 100 µM 0.417776493679118 0.355242310153499 no 1195 0.338055269386807 1620 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_1067 clotrimazole 1.36 µM 0.416992179062423 0.355512647462443 no 1196 0.338342064147431 1594 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1265 0819-1001 68.8 µM 0.416648840360161 0.355631012223782 no 1197 0.33846763990522 1574 3106768
SGTC_2153 5569715 200 µM 0.415791479865354 0.355926644887743 no 1198 0.338781296991789 1628 2054701
SGTC_1123 mangostin 811.285 nM 0.414870041334912 0.356244469372328 no 1199 0.339118521088946 1573 5281650 An antioxidant.
SGTC_1369 1866-0067 208 µM 0.413349256319696 0.356769240084439 no 1200 0.339675373327705 1708 3531355
SGTC_2372 9071633 200 µM 0.413078131630349 0.356862824421032 no 1201 0.339774685436898 1650 21321366
SGTC_1452 4194-0072 190 µM 0.411256998979378 0.357491649332918 no 1202 0.340442048502014 1742 1343545
SGTC_2100 5377183 190 µM 0.40909347584652 0.358239202423825 no 1203 0.341235531960769 1727 2844202
SGTC_799 1310-0557 151 µM 0.406492427241369 0.359138651504219 no 1204 0.342190410013155 1637 5354492
SGTC_2112 5488546 200 µM 0.404081792375844 0.359972952874372 no 1205 0.343076286792072 1589 600757
SGTC_754 3474-0146 171 µM 0.402257920946553 0.360604623962799 no 1206 0.343747109622423 1524 24762078
SGTC_3299 9121982 43.1275 µM 0.400226101631649 0.361308762835146 no 1207 0.344494995675999 1590 17594604 YPL160W CDC60
SGTC_586 0957-0265 8.15 µM 0.400012143097641 0.361382938816065 no 1208 0.344573786460265 1658 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2013 4024628 200 µM 0.397209531749988 0.362355039302009 no 1209 0.345606476925068 1665 5230760
SGTC_1211 1056-0033 32.3 µM 0.395344342463549 0.363002482719835 no 1210 0.34629438929474 1712 6741922
SGTC_3284 9108171 64.8615 µM 0.395058943582641 0.363101584815494 no 1211 0.346399693892172 1645 8687505
SGTC_183 3914-0051 30.55 µM 0.395025767570104 0.363113105470813 no 1212 0.346411935729033 1777 1596232
SGTC_1563 conessine 56.1 µM 0.394259162537667 0.363379350131261 no 1213 0.346694855065272 1695 441082 An anti-amoebic, histamine inhibitor.
SGTC_3184 9108758 49.47 µM 0.393998485910673 0.36346989909958 no 1214 0.346791078541302 1636 902885
SGTC_2569 tetrandrine 100 µM 0.391661971727004 0.364281853752448 no 1215 0.347653995888506 1582 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2823 7987624 58.44 µM 0.3915348962519 0.364326030856155 no 1216 0.347700949869843 1629 2239440
SGTC_406 estrone 100 µM 0.391328124225007 0.364397917888689 no 1217 0.347777356465168 1755 5870 A steroid.
SGTC_3053 9095903 49.47 µM 0.388335774859379 0.365438780597739 no 1218 0.348883783012975 1694 17174018
SGTC_3173 9105693 49.47 µM 0.386854152419351 0.365954517686454 no 1219 0.349432092272922 1709 17096658
SGTC_3103 9120822 49.47 µM 0.386664936324023 0.366020399274335 no 1220 0.349502138801582 1748 17141819
SGTC_484 loperamide 105 µM 0.384503187105557 0.366773360809478 no 1221 0.350302767076438 1657 3955 An opioid-receptor agonist.
SGTC_1764 st044502 93.5 µM 0.384111857067285 0.366909720371264 no 1222 0.350447771843358 1628 8407
SGTC_174 3553-0389 74.3 µM 0.382551771740344 0.367453501313571 no 1223 0.351026067662645 1699 738071
SGTC_2721 ifenprodil 61.44 µM 0.381956662735056 0.367661001712144 no 1224 0.351246754992305 1737 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_2617 dihydrotanshinone i 20.83 µM 0.381772877255874 0.367725091161992 no 1225 0.351314919248023 1615 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1228 0124-0032 52.5 µM 0.380876873878438 0.368037597097391 no 1226 0.351647306692612 1735 X1228
SGTC_1316 1272-0050 65.9 µM 0.380536890049833 0.368156198724416 no 1227 0.351773459086477 1668 7340392
SGTC_2160 5660466 132.927 µM 0.377500390762925 0.369216022162838 no 1228 0.352900887021277 1760 2859134
SGTC_1826 st055655 41.6 µM 0.376575117218889 0.369539166726887 no 1229 0.353244691155963 1662 676168
SGTC_1055 3448-0672 86 µM 0.375842192087197 0.36979520054755 no 1230 0.353517109394975 1667 748378
SGTC_2968 9090663 33.37 µM 0.374571580455283 0.370239201929661 no 1231 0.353989556110263 1668 25236811
SGTC_3188 9110789 49.47 µM 0.373644529616414 0.370563258907255 no 1232 0.354334399863059 1743 849217
SGTC_190 3970-0790 3.722 µM 0.373554311881738 0.370594800043416 no 1233 0.3543679653789 1747 2832352
SGTC_925 2064-1272 59.6 µM 0.370295232698364 0.371734792548906 no 1234 0.355581262762594 1641 6815817
SGTC_2358 9037157 4 µM 0.36949193974133 0.372015949497687 no 1235 0.355880539978281 1699 2388925
SGTC_1134 3477-0009 42.5 µM 0.369430970260936 0.372037291939548 no 1236 0.355903258578931 1845 3973534
SGTC_339 3091-4833 71.4 µM 0.369013201822231 0.372183542870417 no 1237 0.356058942264279 1711 3240077
SGTC_401 neomycin 50 µM 0.367041768020275 0.372873944092307 no 1238 0.356793931304041 1707 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_965 1291-5240 308 µM 0.366877724159643 0.372931411118305 no 1239 0.356855114071545 1768 2834598
SGTC_2556 citropten 84.59 µM 0.366531294082098 0.373052780062784 no 1240 0.356984332777761 1602 2775 A potential DNA crosslinker.
SGTC_3298 9116858 71.43 µM 0.365292381162314 0.373486926095203 no 1241 0.357446582500957 1766 2506942
SGTC_3317 9138495 8.753 µM 0.364709201334359 0.373691342507237 no 1242 0.357664244687358 1675 17020139
SGTC_2821 7996764 71.43 µM 0.364561968253381 0.373742956322913 no 1243 0.357719204312488 1707 2987135
SGTC_40 0327-0103 19.753 µM 0.364557029314167 0.373744687749551 no 1244 0.357721047986317 1633 409036
SGTC_56 0957-0365 83.25 µM 0.362434568726634 0.374488986725719 no 1245 0.358513655416429 1692 6752360
SGTC_1384 3089-0840 101 µM 0.361123610846392 0.37494894399331 no 1246 0.359003521818425 1781 1069836
SGTC_1441 4106-0040 13 µM 0.361039310284208 0.374978527435516 no 1247 0.35903503040473 1686 2904180
SGTC_3278 9139605 49.47 µM 0.36082540445851 0.375053596316835 no 1248 0.359114985185394 1769 7958859
SGTC_3192 9110362 49.47 µM 0.360649305263879 0.375115400755339 no 1249 0.359180813047714 1714 16649480
SGTC_345 1362-0200 395 µM 0.360642395763403 0.375117825805109 no 1250 0.359183395982062 1623 1419823
SGTC_2162 5663267 200 µM 0.360507839563873 0.375165052414453 no 1251 0.359233697548099 1782 6456493
SGTC_39 0986-0283 58.349 µM 0.360030907254944 0.375332461447926 no 1252 0.359412010295896 1827 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_9 0092-0002 10.449 µM 0.359755826345148 0.375429028868163 no 1253 0.359514869913032 1688 759368
SGTC_2897 9048598 12.99 µM 0.359153711947521 0.375640428946868 no 1254 0.359740051030439 1673 6467404
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.358559066500744 0.375849243354364 no 1255 0.359962486679057 1690 521171
SGTC_2514 salinomycin 42.74 µM 0.356464247644404 0.376585144713036 no 1256 0.360746461088431 1845 23682228 A polyether potassium ionophore.
SGTC_2513 baicalein 25.65 µM 0.3564162734076 0.376602003133692 no 1257 0.360764422053048 1599 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_1239 0337-0584 35.4 µM 0.355200517975779 0.377029305003011 no 1258 0.36121968835326 1823 914301 YML130C ERO1
SGTC_982 1491-0518 27.5 µM 0.355092014915084 0.377067447931062 no 1259 0.361260329272123 1701 3091256
SGTC_300 r073-0011 5.04 µM 0.35473079070512 0.37719444054058 no 1260 0.361395640735322 1734 2735780
SGTC_2109 5483026 200 µM 0.353388382902195 0.377666496058023 no 1261 0.361898646914153 1714 759335
SGTC_455 paf C-16 10 µM 0.353165950410469 0.377744731752106 no 1262 0.361982016430769 1689 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_1174 0739-0097 51.1 µM 0.351842141210275 0.378210455917336 no 1263 0.362478326300585 1705 728447
SGTC_2875 9039966 71.43 µM 0.351801687771771 0.378224690474781 no 1264 0.36249349636111 1804 6463691
SGTC_467 ro 31-8220 72.8 µM 0.35174602901271 0.378244275675961 no 1265 0.362514368777635 1806 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_3333 9141820 12.094 µM 0.351141988923691 0.37845684538117 no 1266 0.36274091422514 1674 1939433
SGTC_755 1995-0008 37.3 µM 0.350914606833915 0.378536873682662 no 1267 0.362826206411574 1684 689533
SGTC_2472 5377652 49.4 µM 0.349372768934489 0.379079668764291 no 1268 0.363404737048113 1675 1610903
SGTC_2963 9082507 9 µM 0.349111396572042 0.379171707059919 no 1269 0.363502840496209 1744 16459611
SGTC_260 nsc-65238 3.989 µM 0.348560444899053 0.379365738729767 no 1270 0.363709663899173 1767 3246252
SGTC_2218 6965428 192.983 µM 0.348459973753989 0.379401125481131 no 1271 0.363747384347974 1777 675684
SGTC_2134 5324836 1.464 µM 0.348191101544351 0.37949582942091 no 1272 0.363848335053508 1735 699272
SGTC_81 0411-0046 9.971 µM 0.347641922821101 0.379689287226982 no 1273 0.364054558946509 1674 12925265
SGTC_2799 7812892 81.82 µM 0.347455658914606 0.379754908786741 no 1274 0.36412451245834 1813 20205235
SGTC_582 0987-0078 156 µM 0.347248246179274 0.379827985243134 no 1275 0.364202413979078 1726 1625765
SGTC_2123 5259487 200 µM 0.347183157711629 0.379850918348374 no 1276 0.364226861516209 1802 2173474
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.346716601193576 0.380015316051397 no 1277 0.364402118524563 1694 6708784 An antioxidant flavonoid
SGTC_1865 st057639 52.2 µM 0.345929669626885 0.380292651490877 no 1278 0.364697785245447 1723 688818
SGTC_2126 5251174 33.877 µM 0.345905101909684 0.380301310793915 no 1279 0.36470701714953 1890 790722
SGTC_2814 7977482 42.97 µM 0.345833188684549 0.380326658158278 no 1280 0.364734040705243 1819 6456762
SGTC_2250 alverine citrate 130 µM 0.345710981908872 0.380369733745884 no 1281 0.364779965115584 1676 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1205 4161-2785 76 µM 0.345562402716841 0.380422107112017 no 1282 0.364835802700096 1625 3498106
SGTC_2308 7584454 197.62 µM 0.345434003163627 0.38046736902972 no 1283 0.364884058878706 1805 893577
SGTC_870 0573-2213 57.6 µM 0.34392182706503 0.381000546736458 no 1284 0.365452538216577 1665 3916321
SGTC_1160 4092-0570 10.5 µM 0.343079830743754 0.381297523989346 no 1285 0.365769202027015 1643 4994975
SGTC_1394 3474-0001 65.7 µM 0.341104632132376 0.381994462708098 no 1286 0.366512407098151 1688 5017666 YIL048W NEO1
SGTC_765 1319-0117 244 µM 0.339655700729341 0.382505954142586 no 1287 0.367057913019931 1654 3487746 YGL099W LSG1
SGTC_1355 1499-0035 1.68 µM 0.3394485285095 0.38257910537823 no 1288 0.3671359329317 1686 1548538
SGTC_2088 5278280 127.392 µM 0.339286951929178 0.382636159982411 no 1289 0.367196785586442 1731 791502
SGTC_2471 5466956 24.79 µM 0.339226247501947 0.382657596092992 no 1290 0.367219648830957 1758 724419
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.338749183595689 0.382826070691513 no 1291 0.367399342862548 1761 6708739 YPR165W RHO1
SGTC_559 1550-0661 158 µM 0.337649678034826 0.383214444272555 no 1292 0.367813600404447 1766 5830875
SGTC_312 4092-0653 6.84 µM 0.336659636209264 0.383564252922933 no 1293 0.368186747234883 1799 1148278
SGTC_153 4077-0274 519.67 µM 0.336432755619778 0.383644429372973 no 1294 0.368272276075435 1856 3121976
SGTC_2399 5884133 200 µM 0.335176191316622 0.384088571867893 no 1295 0.368746090444387 1660 722445
SGTC_1087 pterostilbene 9.05 µM 0.334030554269401 0.384493638970919 no 1296 0.369178251288844 1834 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1371 2421-0008 32.7 µM 0.333510511591619 0.384677554028908 no 1297 0.369374478053563 1726 2827552
SGTC_2272 7805186 180 µM 0.332651846138137 0.384981281103888 no 1298 0.369698551212442 1874 2956062 YPR165W RHO1
SGTC_2304 7443016 91.4 µM 0.332316095272308 0.385100062079805 no 1299 0.369825293790046 1706 939854
SGTC_1196 1588-0294 184 µM 0.332024696480199 0.385203161046714 no 1300 0.369935305369313 1688 6144269
SGTC_1000 4048-0884 8.67 µM 0.330410472875755 0.385774431645293 no 1301 0.370544914636123 1767 13040088
SGTC_2956 9076196 2.52 µM 0.329852975036135 0.38597178668822 no 1302 0.370755528537483 1767 16423868
SGTC_354 2783-3500 4.88 µM 0.32867714611276 0.386388128544197 no 1303 0.371199865109317 1660 6740761
SGTC_3229 9132204 49.47 µM 0.327975677526164 0.386636569477477 no 1304 0.371465026443867 1783 17682924
SGTC_3098 9119039 49.47 µM 0.326881262226688 0.387024274132184 no 1305 0.371878846920042 1729 17161528
SGTC_2558 carylophyllene oxide 100 µM 0.32581687662422 0.387401448702829 no 1306 0.372281454596263 1768 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_957 1187-1561 14.1 µM 0.325779475313261 0.387414704127785 no 1307 0.372295604318545 1751 1538454
SGTC_2809 7964133 12.99 µM 0.325034848311338 0.387678635208208 no 1308 0.372577348629276 1762 1253665
SGTC_2258 7960471 200 µM 0.324177753684233 0.387982494398539 no 1309 0.372901731702864 1717 2974708
SGTC_831 k061-1017 217 µM 0.32368752801361 0.388156321199564 no 1310 0.373087307074812 1854 1240153
SGTC_2635 hydroquinidine 100 µM 0.323605489052773 0.388185413196267 no 1311 0.373118365875427 1732 442912 An experimental heart treatment.
SGTC_1675 st018485 24.5 µM 0.322162127450778 0.388697348968438 no 1312 0.373664937046616 1733 3323024
SGTC_148 3253-0744 288.01 µM 0.321916915354608 0.388784340761249 no 1313 0.373757819083978 1692 6893655
SGTC_140 0062-0056 502.533 µM 0.318673703467043 0.3899354303326 no 1314 0.374986978695207 1678 3758964
SGTC_2146 5545642 200 µM 0.318248643872496 0.390086365446075 no 1315 0.375148168419349 1767 825326
SGTC_3174 9107204 49.47 µM 0.317603349844555 0.390315535637718 no 1316 0.375392916405125 1820 3938802
SGTC_1076 itraconazole 331 nM 0.317342448800225 0.390408203050738 no 1317 0.375491885550459 1766 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1958 st076513 41.9 µM 0.315112040926796 0.391200657898398 no 1318 0.376338293281982 1726 732122 YGL099W LSG1
SGTC_264 promethazine 12.5 mM 0.314801554851264 0.391311008243084 no 1319 0.376456165557335 1857 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_2332 7982454 138.89 µM 0.313931445211651 0.391620301866753 no 1320 0.37678655348963 1754 2981748
SGTC_641 4092-0595 30 µM 0.312721457447607 0.392050524170429 no 1321 0.377246145979567 1834 786260
SGTC_1526 st051518 75 µM 0.312264085490639 0.392213181395045 no 1322 0.377419915975596 1741 673993
SGTC_4 0960-0234 25.671 µM 0.311915411739784 0.392337194447235 no 1323 0.377552404777818 1751 6821112
SGTC_1308 1187-1617 41.4 µM 0.311492324074269 0.392487689034888 no 1324 0.377713188675684 1745 2882570
SGTC_1907 st060210 83.7 µM 0.309356867424627 0.393247527543192 no 1325 0.378525038494198 1852 688793
SGTC_3247 9135149 49.47 µM 0.308057555713832 0.39371004809811 no 1326 0.379019268635569 1780 8934436 YOR116C RPO31
SGTC_1166 k206-0078 225 µM 0.305768053307619 0.394525414969051 no 1327 0.37989062698675 1736 5404595
SGTC_55 0767-0285 6.563 µM 0.305743709929242 0.394534086934421 no 1328 0.379899895083211 1895 3116166
SGTC_3176 9106582 49.47 µM 0.30532709837377 0.39468250668366 no 1329 0.380058519584911 1877 17018027
SGTC_2420 aureobasidin a 50 nM 0.305186748597113 0.394732510369455 no 1330 0.380111962190369 1905 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_1282 0886-0010 32.4 µM 0.304374700396371 0.395021860155739 no 1331 0.380421220071553 1919 2836211 YNL267W PIK1
SGTC_1015 4130-4525 82 µM 0.30373286088731 0.395250601997825 no 1332 0.380665710310841 1729 1363237
SGTC_3070 9117005 49.47 µM 0.302941721047756 0.395532601871571 no 1333 0.38096713778209 1845 8779016
SGTC_1462 k081-0014 26.5 µM 0.300487731688638 0.396407667813101 no 1334 0.381902576503303 1702 3270634
SGTC_1802 st050112 57.9 µM 0.299586175857627 0.396729284202745 no 1335 0.382246415089516 1807 4662563
SGTC_408 cantharidin 100 µM 0.298261940018072 0.39720181263068 no 1336 0.382751625224313 1808 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3002 9075603 71.4286 µM 0.298247825640088 0.397206849892739 no 1337 0.382757011086853 1815 20105405
SGTC_855 0428-0020 25 µM 0.296753249934556 0.397740343956819 no 1338 0.383327449798022 1790 6812414
SGTC_1444 4112-3581 28 µM 0.296379938540816 0.397873628671014 no 1339 0.383469972100519 1805 2877249
SGTC_785 1270-0111 65.3 µM 0.295933260311505 0.398033123474877 no 1340 0.383640525012705 1767 6741994
SGTC_2243 6634756 200 µM 0.295172035871812 0.398304972130142 no 1341 0.383931231464863 1900 885676
SGTC_2017 5132927 60.65 µM 0.294834099219203 0.398425671978567 no 1342 0.38406030812818 1721 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_1085 doxorubicin 7.67 µM 0.294446681961184 0.398564056626372 no 1343 0.384208299989253 1883 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3081 9117243 49.47 µM 0.294089911921343 0.398691505433158 no 1344 0.384344599667051 1911 45595589
SGTC_751 0833-0568 350 µM 0.292887835409626 0.399121002158283 no 1345 0.38480394363689 1818 6954252
SGTC_22 0964-0034 14.468 µM 0.292292042194686 0.399333921798853 no 1346 0.385031671348783 1772 138402
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.291923193480047 0.399465752908405 no 1347 0.38517267483344 1771 6857784
SGTC_3088 9117578 49.47 µM 0.291417929140286 0.399646359260728 no 1348 0.385365851924083 1858 678341
SGTC_1342 1486-1464 234 µM 0.290471766687075 0.399984622037354 no 1349 0.385727673519909 1784 3253938
SGTC_981 1488-1094 54.9 µM 0.290065551786605 0.400129871073781 no 1350 0.385883044525963 1781 3449522
SGTC_1940 st075990 51.1 µM 0.289524011005843 0.400323529661016 no 1351 0.386090204086934 1866 1084979
SGTC_2477 5967686 25.23 µM 0.287270476660024 0.401129671238166 no 1352 0.386952613289334 1751 776118
SGTC_1317 1273-0028 910 nM 0.284401506782267 0.402156577339713 no 1353 0.388051352205738 1809 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_302 1094-0063 18.9 µM 0.283191983221129 0.402589711635508 no 1354 0.388514836697023 1807 5440289
SGTC_1642 st009582 77.7 µM 0.282514183140479 0.402832486359337 no 1355 0.388774636382607 1935 6739311
SGTC_634 1611-4317 11.2 µM 0.27772566932649 0.404548700559763 no 1356 0.390611477100276 1959 2843522
SGTC_2607 solasodine 47.35 µM 0.277723892414587 0.404549337752211 no 1357 0.390612159167479 1780 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1735 st034310 56.75 µM 0.275998853848476 0.405168047828484 no 1358 0.391274473276761 1896 871153
SGTC_1637 st007924 17.4 µM 0.27415271241431 0.405830455818767 no 1359 0.391983633170354 1797 683336
SGTC_245 methotrexate 289.6 µM 0.273290479114482 0.406139923458885 no 1360 0.392314966718277 1873 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_1253 0550-0034 176 µM 0.272761065777768 0.406329966414555 no 1361 0.392518445025621 1815 5969915
SGTC_2606 farnesol 9.78 µM 0.272705415362218 0.406349944469015 no 1362 0.392539835790931 1914 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_933 2914-0560 114 µM 0.269092634379598 0.407647423357456 no 1363 0.393929199186031 1991 463887
SGTC_2170 morpholine 200 µM 0.267548425938281 0.408202313921413 no 1364 0.394523467035919 1919 121171 Reacts with secondary amines.
SGTC_1328 1441-0025 69.2 µM 0.266795729324297 0.408472852162101 no 1365 0.394813221308795 1738 4562601
SGTC_27 0485-0001 32.618 µM 0.266781452694058 0.408477983966845 no 1366 0.394818717730834 1941 2054479
SGTC_1502 4534-4282 27.7 µM 0.266253719426197 0.408667691283025 no 1367 0.395021906740049 1839 3278949
SGTC_944 3370-0224 231 µM 0.266043856225525 0.408743137966144 no 1368 0.395102716663222 1777 4580514
SGTC_846 0335-0850 148 µM 0.265829163509299 0.408820324379393 no 1369 0.395185390908523 1875 6819598
SGTC_2790 5423970 71.43 µM 0.26316664474 0.409777847178653 no 1370 0.396211069261991 1937 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1880 MG-132 525 µM 0.263108762487296 0.409798669398007 no 1371 0.396233375169685 1943 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_1860 st056228 74.6 µM 0.262981540714892 0.40984443630016 no 1372 0.396282403430993 1799 688679
SGTC_2871 9038510 12.99 µM 0.261659830939021 0.410319982205108 no 1373 0.396791856017815 1986 4945164
SGTC_3206 9114350 49.47 µM 0.26100918729537 0.410554129682673 no 1374 0.397042711167956 1935 17087243
SGTC_274 sirtinol 40.1 µM 0.258997766583719 0.411278182018354 no 1375 0.397818481861647 1784 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_2643 anethole 100 µM 0.257874934871019 0.411682500075014 no 1376 0.398251714923583 1865 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_2880 9042983 58.44 µM 0.254491097259269 0.412901544473505 no 1377 0.3995580905503 1845 6464714
SGTC_1481 3346-2004 36 µM 0.254454118189147 0.412914871031703 no 1378 0.399572373055746 1922 2770522
SGTC_3166 9102297 49.47 µM 0.252674264407576 0.413556415097275 no 1379 0.400259968355983 1811 25237072
SGTC_971 1315-0384 26.7 µM 0.252542385514025 0.41360395973738 no 1380 0.400310928305037 1788 6769120
SGTC_1771 st048882 4.1505 µM 0.25154805621193 0.413962473516536 no 1381 0.400695206391182 1775 4580403
SGTC_1426 4048-4480 71.7 µM 0.251024186576844 0.414151387977422 no 1382 0.400897704786881 1936 14224343
SGTC_1232 0279-0259 161 µM 0.248097620135711 0.415207111615044 no 1383 0.402029438461896 1814 1560000
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.248008389103184 0.415239310297635 no 1384 0.402063957990049 1839 75037 A free radical scavenger.
SGTC_2970 9090938 41.86 µM 0.245965333146297 0.415976694673206 no 1385 0.402854534178996 2014 17217104
SGTC_1353 1498-1206 8.11 µM 0.245749944058904 0.416054450676357 no 1386 0.402937903849244 1871 6756808
SGTC_3320 9137005 35.139 µM 0.245596297231328 0.416109919576428 no 1387 0.402997377922028 1841 4908713
SGTC_1249 0481-0015 10.2 µM 0.245240745970104 0.416238285530548 no 1388 0.403135014369464 1830 4227577
SGTC_195 4234-0266 16.654 µM 0.244827890567359 0.416387351415924 no 1389 0.403294848719842 1882 2303354
SGTC_743 1275-0778 158 µM 0.24480872195969 0.416394272740288 no 1390 0.403302270117395 1957 2849257 YMR203W TOM40
SGTC_3112 9123419 49.47 µM 0.243138137648668 0.416997580007225 no 1391 0.403949193954942 1935 17015854
SGTC_280 3448-3607 3.04 µM 0.243057293448297 0.417026780687302 no 1392 0.403980507071437 1994 626179
SGTC_2441 5730946 39.09 µM 0.242986704735204 0.417052277490785 no 1393 0.404007848467175 1944 1774275
SGTC_3215 9129942 49.47 µM 0.242631292191993 0.417180658606691 no 1394 0.404145518886824 2025 17682944
SGTC_1168 k815-0004 80.5 µM 0.24108790917289 0.417738257329527 no 1395 0.404743491760888 1870 642433
SGTC_197 4544-0043 41.561 µM 0.239725490970946 0.418230613972906 no 1396 0.405271536066679 1919 896523
SGTC_1916 st067606 49.2 µM 0.239380907235288 0.418355161485819 no 1397 0.405405116757353 1953 19590279
SGTC_43 0570-0105 72.5 µM 0.238759484519398 0.41857979130353 no 1398 0.405646044176947 1875 1114046 YDL195W SEC31
SGTC_1694 st024011 44.9 µM 0.237955010981919 0.418870629151424 no 1399 0.405957994023091 1945 2787533
SGTC_80 0159-0065 512.242 µM 0.236507810635705 0.419393940791666 no 1400 0.406519323584547 1999 1548079
SGTC_1779 st039427 55 µM 0.23610079427246 0.419541144765959 no 1401 0.406677228805834 2065 1124498
SGTC_3036 9090181 49.47 µM 0.236097737524799 0.419542250330242 no 1402 0.406678414752737 1882 25236586
SGTC_1974 st069448 26.9 µM 0.234814759835279 0.42000633358283 no 1403 0.407176255656014 2004 6323587 YNR016C ACC1
SGTC_1225 1216-0074 20.6 µM 0.233118275607224 0.420620162609033 no 1404 0.407834781966232 1860 4241466
SGTC_880 0833-0487 87.2 µM 0.232610929722251 0.420803770191702 no 1405 0.408031769704584 1847 76075
SGTC_952 1185-0122 232 µM 0.231762882861693 0.421110715306982 no 1406 0.40836109366654 1908 678600
SGTC_2307 7538926 6.34 µM 0.230969400183748 0.421397954698089 no 1407 0.408669287220034 1869 96582
SGTC_1581 himbacine 57.9 µM 0.230218722826065 0.421669737148987 no 1408 0.408960906925963 1862 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_1547 harmine 94.2 µM 0.228556952083564 0.422271513171599 no 1409 0.409606643081873 1909 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1367 1812-0510 76.9 µM 0.228374226851216 0.422337694449196 no 1410 0.40967766203342 1945 1142582 YDR527W RBA50
SGTC_2018 5133068 143 µM 0.227995531862289 0.422474861019635 no 1411 0.409824857056344 1888 785362
SGTC_1294 1000-1494 117 µM 0.227883942077173 0.422515281590272 no 1412 0.40986823333509 1843 712797 YDL207W GLE1
SGTC_877 0771-0151 33.1 µM 0.227711540967067 0.422577731125645 no 1413 0.409935249868578 1926 6166523
SGTC_1766 st045414 44.774 µM 0.226857916713721 0.422886971455167 no 1414 0.410267113248052 1910 253960
SGTC_483 fpl-64176 144 µM 0.226785745070613 0.422913119077811 no 1415 0.410295174357411 1952 3423
SGTC_1202 1988-0068 29.6 µM 0.226763086619801 0.422921328253212 no 1416 0.410303984300988 1822 2850480
SGTC_621 3584-0052 32.1 µM 0.226693761155 0.422946445134081 no 1417 0.410330939356644 2023 2273927
SGTC_2378 9074213 121.43 µM 0.225684699477711 0.42331206744384 no 1418 0.410723329570515 1948 657714
SGTC_99 0109-0120 622.8 µM 0.224738227937208 0.423655070949482 no 1419 0.4110914618143 1987 759414
SGTC_1320 1313-0481 95.3 µM 0.223915695772148 0.423953205532695 no 1420 0.411411451171166 2019 6813365 YLR208W SEC13
SGTC_1723 st034307 2.5525 µM 0.223768891616643 0.424006420673712 no 1421 0.411468568537122 1879 867466
SGTC_1096 rimcazole 32.2 µM 0.223324412765151 0.424167548568623 no 1422 0.411641514186856 1895 18528119 A dopamine reuptake inhibitor.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.22193975347442 0.424669582128439 no 1423 0.412180391678873 1802 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2353 9059630 146.67 µM 0.22115409086262 0.42495449288492 no 1424 0.412486227179018 1989 4779114
SGTC_1896 st058441 89 µM 0.220683893216451 0.425125022964425 no 1425 0.412669286816491 1865 688759
SGTC_161 4065-0411 162.148 µM 0.220588398835037 0.425159658335135 no 1426 0.412706467476147 1917 1906281 YLR208W SEC13
SGTC_2455 5377712 9.75 µM 0.218847772356243 0.425791076475358 no 1427 0.413384315900993 1830 2243908
SGTC_1154 4088-0362 150 µM 0.215095007336948 0.427153050161955 no 1428 0.41484662318873 1930 6618304
SGTC_1645 Cervolide 78 µM 0.213643782636385 0.427679970285467 no 1429 0.415412426982689 1911 23173 A fragrance.
SGTC_119 0121-0043 24.815 µM 0.213329012266204 0.427794276221654 no 1430 0.415535172915394 2038 1092378
SGTC_791 1348-1292 225 µM 0.212379008910468 0.428139297824485 no 1431 0.415905680358143 2004 5437054
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.207805711513244 0.429800989321248 no 1432 0.417690336411981 2007 688751
SGTC_1966 st070145 16.1 µM 0.206079677118196 0.430428462873107 no 1433 0.418364336679392 1933 3748532
SGTC_2433 5607874 27.82 µM 0.204177435031647 0.431120197531144 no 1434 0.41910742207758 1926 2252428
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.203880835700536 0.431228072532119 no 1435 0.419223310713378 2017 17037758
SGTC_1556 plumbagin 1.48 µM 0.201841819422355 0.431969813739967 no 1436 0.420020193576335 2030 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.198778547732887 0.433084602603294 no 1437 0.421217988773396 1939 115019
SGTC_2815 7968870 71.43 µM 0.198682428444496 0.433119591095766 no 1438 0.421255585033137 1928 2977326 YHR190W ERG9
SGTC_473 2-arachidonoylglycerol 10 µM 0.19750148458974 0.433549510530399 no 1439 0.421717559893124 1889 5282280 An endocannabinoid.
SGTC_2007 4011539 71.82 µM 0.196479425883707 0.433921651752176 no 1440 0.422117467291661 1945 45595301
SGTC_2241 6772625 37.8075 µM 0.196197778182828 0.434024212647526 no 1441 0.422227683508325 2107 2285411
SGTC_1375 2910-0797 186 µM 0.195039955494444 0.434445875781523 no 1442 0.422680834130779 1958 742508
SGTC_1105 epirubicin 18.1 µM 0.194673867744815 0.434579215458788 no 1443 0.422824135503074 1912 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2355 9061122 103.12 µM 0.194447469707058 0.434661679854489 no 1444 0.422912761853031 2049 5302957
SGTC_3220 9131269 49.47 µM 0.19427155594201 0.434725757559522 no 1445 0.42298162819541 2038 17722206
SGTC_2470 5664817 21.68 µM 0.19425526851462 0.434731690445037 no 1446 0.422988004481527 2078 2859561
SGTC_2560 caryophyllene 100 µM 0.194173862596625 0.43476134372102 no 1447 0.423019873992721 2040 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_1868 st057644 42.7 µM 0.193971523272929 0.434835050317996 no 1448 0.423099089768526 2011 688665
SGTC_3037 9091026 49.47 µM 0.193672709396455 0.434943904056693 no 1449 0.423216080983897 2026 25236398 YIL048W NEO1
SGTC_348 k064-0012 10.7 µM 0.193414879401988 0.435037831900508 no 1450 0.423317031685577 1942 5066323
SGTC_2356 9061756 188.97 µM 0.192342724587232 0.435428458726124 no 1451 0.42373687687743 2065 20104043
SGTC_142 0335-0849 62.6745 µM 0.191880024026882 0.435597057647792 no 1452 0.423918092602917 1991 3889043 YPR107C YTH1
SGTC_976 1348-1067 47.6 µM 0.191256304820386 0.435824347096429 no 1453 0.424162396406603 1994 5310671 YGL099W LSG1
SGTC_1978 st071761 42 µM 0.190771985892746 0.436000852329452 no 1454 0.424352118794362 1915 5147680
SGTC_1990 st072050 59.8 µM 0.189613850595443 0.436422974881129 no 1455 0.424805866454213 1901 17233948
SGTC_1028 k015-0029 4.8 µM 0.187812849902672 0.437079555706573 no 1456 0.425511681128491 1985 4588309
SGTC_2867 9039098 71.43 µM 0.186416232097343 0.437588832334293 no 1457 0.426059182081326 1927 6463460
SGTC_1159 4092-0538 61.2 µM 0.186023684203688 0.437731993562254 no 1458 0.426213094091408 1966 717301
SGTC_897 1000-0139 31.4 µM 0.185883262502246 0.437783206983472 no 1459 0.42626815401804 2093 6151020
SGTC_934 2950-0684 338 µM 0.184153001298136 0.438414338568191 no 1460 0.426946714185753 2094 1121253
SGTC_115 0527-0192 112.043 µM 0.179802874785935 0.440001783035103 no 1461 0.428653663324033 1962 4233931
SGTC_1830 st055982 50.3 µM 0.177714190933117 0.440764328260992 no 1462 0.429473719951198 2121 455313 An antimicrobial agent.
SGTC_277 nystatin 15.5 µM 0.174588516133669 0.441905871921674 no 1463 0.430701486393874 2004 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3161 9100388 49.47 µM 0.173549601409144 0.442285406616287 no 1464 0.431109721528083 2038 25236368
SGTC_2675 theaflavin digallate 100 µM 0.17332198968916 0.44236856445946 no 1465 0.43119916999509 2048 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1693 xanthone 101.9 µM 0.172894258928592 0.442524842574515 no 1466 0.431367272204137 2050 7020 An insecticide.
SGTC_2792 7535235 81.82 µM 0.171541248772481 0.443019244749555 no 1467 0.431899099630359 1929 1281891
SGTC_1139 k015-0024 46.9 µM 0.169725784738175 0.443682771038674 no 1468 0.432612897491956 2127 2766652
SGTC_2522 biochanin a 4.94 µM 0.169519909851571 0.443758025386248 no 1469 0.432693856596712 2063 5280373 A possible chelator.
SGTC_2087 5276107 200 µM 0.167091005238416 0.444646025900468 no 1470 0.433649221650436 2066 144405
SGTC_2655 perillic acid 100 µM 0.166999005417391 0.444679666259676 no 1471 0.433685415748955 1990 5702197 An apoptosis inducer.
SGTC_1848 st056003 16.4 µM 0.166916788217209 0.444709729874324 no 1472 0.433717761689416 2165 146492
SGTC_1136 pergolide 1.05886 µM 0.163769851898911 0.44586067889055 no 1473 0.434956162948916 1972 47811 A dopamine receptor agonist.
SGTC_1238 0333-0287 48.8 µM 0.162208663285204 0.446431832290632 no 1474 0.435570768917437 2026 7226
SGTC_34 0469-0683 81.75 µM 0.16155570000531 0.446670748823434 no 1475 0.435827872596466 2070 3690923
SGTC_1050 3232-1156 69.3 µM 0.161323998554731 0.446755532072897 no 1476 0.435919111350751 1977 700529
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.160947292284564 0.446893380087601 no 1477 0.436067456978308 2019 15053
SGTC_2626 ethyl orsellinate 100 µM 0.160839252981432 0.446932916062807 no 1478 0.436110004143191 2026 75653 A natural product.
SGTC_1059 3448-6867 171 µM 0.160262222136391 0.447144084039329 no 1479 0.436337258273098 2159 3934407
SGTC_565 1418-0001 44.5 µM 0.159324328588655 0.447487343881976 no 1480 0.436706677065656 2103 2862145
SGTC_545 4218-0007 221 µM 0.159304121055735 0.44749474007469 no 1481 0.43671463704502 2040 2840508
SGTC_1834 st055981 52.8 µM 0.157557490156807 0.448134096069551 no 1482 0.437402751507181 2125 471719 YDL150W RPC53
SGTC_249 wiskostatin 11.211 µM 0.157466862599858 0.448167274069502 no 1483 0.437438460935446 2109 2775510 A n-wasp and actin depolymerizer.
SGTC_1495 4469-0029 237 µM 0.157331403614225 0.448216865161066 no 1484 0.437491835970481 2079 793680
SGTC_1260 0700-1617 7.75 µM 0.157189132840893 0.448268950897135 no 1485 0.437547896285571 2028 2853078
SGTC_1014 4130-3005 69.3 µM 0.157046641407264 0.448321118311451 no 1486 0.437604044806183 1959 743608
SGTC_1506 4226-2149 212 µM 0.156712603073115 0.448443416295832 no 1487 0.437735676998785 2044 991114
SGTC_948 3448-0295 75.3 µM 0.15564674271623 0.448833681378 no 1488 0.438155739273893 2072 678569
SGTC_1984 st072354 53.1 µM 0.154904281524802 0.44910556304126 no 1489 0.438448389112405 2047 5762938
SGTC_3296 9122258 64.045 µM 0.154809372522034 0.449140319468799 no 1490 0.438485801045302 2022 4730474
SGTC_990 3985-0011 41.3 µM 0.154005410210245 0.449434752455105 no 1491 0.438802734874519 2048 5399565 YGL099W LSG1
SGTC_802 4112-3352 742 µM 0.153853357127754 0.449490441588295 no 1492 0.438862680866611 2106 704594
SGTC_2207 7258803 200 µM 0.153242539361093 0.44971416237154 no 1493 0.439103506130848 2117 3666799
SGTC_1274 0865-0114 173 µM 0.151306567814256 0.450423345046688 no 1494 0.439866944282679 2051 870624
SGTC_3123 9126162 49.47 µM 0.151251366938371 0.450443568494747 no 1495 0.439888715692312 2049 25239884
SGTC_1898 st060199 18.6 µM 0.151175542539578 0.45047134780702 no 1496 0.43991862138451 2022 688866
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.148278516671037 0.4515328935999 no 1497 0.44106148457171 2150 229346 A bile salt which induces apoptosis.
SGTC_1152 3909-8331 15.9 µM 0.147977742733907 0.451643125004595 no 1498 0.441180166783857 1999 16001939
SGTC_896 0964-0007 44.5 µM 0.147542841066422 0.451802519813211 no 1499 0.44135178371713 2176 6756758
SGTC_3256 9138902 49.47 µM 0.147015385887215 0.451995846620112 no 1500 0.441559938048068 2150 17228773
SGTC_3207 9114163 49.47 µM 0.146462723015881 0.452198424950255 no 1501 0.441778057631225 2167 849233
SGTC_686 1319-0111 510 µM 0.146289497516574 0.452261923244365 no 1502 0.441846428216526 2141 4562600
SGTC_217 ketoconazole 989 nM 0.145528426385547 0.452540919241738 no 1503 0.4421468368185 2112 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_1680 diphenhydramine 100 µM 0.143457776026835 0.453300103381333 no 1504 0.44296432805562 2001 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2237 6667747 47.222 µM 0.142211451374763 0.453757138865132 no 1505 0.443456493417203 1988 729940 YDL015C TSC13
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.141743148903976 0.453928884337738 no 1506 0.443641445554302 2015 23665772 A membrane-active detergent.
SGTC_281 1672-3440 14.9 µM 0.141245380441497 0.454111445627185 no 1507 0.443838048497352 2132 6833000
SGTC_269 exalamide 29 µM 0.141218996071906 0.454121122615081 no 1508 0.443848469882667 2059 3316 A derivative of salicylamide.
SGTC_2842 9000675 19.48 µM 0.140594017201801 0.454350353891981 no 1509 0.444095337435724 1939 2989072
SGTC_805 3852-0218 479 µM 0.137646106100028 0.455431799673052 no 1510 0.445260057458539 1982 6615355
SGTC_2517 totarol 10 µM 0.137351846800996 0.455539767419891 no 1511 0.445376345453231 2012 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1048 3161-0300 24.5 µM 0.137143671503428 0.455616151757215 no 1512 0.445458616849502 2133 2165101
SGTC_2614 arthonioic acid 13.39 µM 0.136437002410991 0.455875457232238 no 1513 0.44573791173472 2156 6710684
SGTC_116 0155-0182 31.788 µM 0.135298824360596 0.456293140268287 no 1514 0.446187807278266 2012 771486
SGTC_954 1189-0853 2.85 µM 0.13456969786685 0.4565607369679 no 1515 0.446476050617531 2195 2828194
SGTC_927 2425-1185 123 µM 0.134140638234436 0.456718215350494 no 1516 0.446645682673753 2030 730375
SGTC_3288 9119690 36.221 µM 0.13310089709873 0.457099861203627 no 1517 0.44705679283917 2047 17595618 YKL019W RAM2
SGTC_2896 9052656 71.43 µM 0.132788293571449 0.457214612747711 no 1518 0.447180406372463 2138 6469436
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.132624609862239 0.457274699732522 no 1519 0.447245134246459 2127 5377381
SGTC_2085 5307070 144.047 µM 0.129898934265337 0.458275416019606 no 1520 0.448323193739191 2045 2840351
SGTC_1851 st056236 18.9 µM 0.129806459486858 0.458309372283712 no 1521 0.448359776113467 2192 5393171
SGTC_1388 3346-4487 254 µM 0.12967701386942 0.458356904561131 no 1522 0.448410984630032 2109 3345614
SGTC_652 0437-0092 114 µM 0.128908778376514 0.458639011955597 no 1523 0.448714915244555 2139 3091274
SGTC_1701 st028638 40.4 µM 0.127962932881182 0.458986368960034 no 1524 0.449089153550873 2172 3490878
SGTC_958 1222-0007 33 µM 0.125766269851528 0.459793202789631 no 1525 0.449958471239988 2146 7312461
SGTC_891 0929-0073 133 µM 0.125293081775345 0.459967026454659 no 1526 0.450145764484561 2150 5603632
SGTC_1163 k060-0048 49.9 µM 0.124720240948116 0.460177467377378 no 1527 0.450372516280733 2175 6809982
SGTC_2211 7117706 200 µM 0.124677623223703 0.460193124028635 no 1528 0.450389386616299 2190 822771
SGTC_1811 st050069 61.5 µM 0.124344162243666 0.460315631109275 no 1529 0.45052139109323 2213 3877702
SGTC_1784 st039334 36.3 µM 0.124017793469123 0.460435536299374 no 1530 0.450650593336901 2201 3496984
SGTC_1558 st069300 45.6 µM 0.123885747759356 0.460484049824574 no 1531 0.450702868825612 2187 24208000
SGTC_3337 9144342 33.5465 µM 0.122897565848161 0.460847125968663 no 1532 0.451094106593697 2153 17682949
SGTC_955 1216-0110 33 µM 0.122763596614299 0.460896351239668 no 1533 0.451147150922993 2127 3619719
SGTC_1814 st052110 31.539 µM 0.122595129064232 0.460958253323442 no 1534 0.451213855895644 2178 674163
SGTC_2677 mitomycin C 100 µM 0.122065758395186 0.461152772585785 no 1535 0.451423469943136 2146 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.12188809944144 0.46121805612832 no 1536 0.451493820310265 2195 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2449 5812982 45.77 µM 0.121691533065954 0.461290288714518 no 1537 0.451571659517131 2189 776185
SGTC_590 k048-0076 22.4 µM 0.119822622354943 0.461977124024852 no 1538 0.452311830501983 2201 6832814
SGTC_2286 7945697 125 µM 0.119512268519076 0.462091191858506 no 1539 0.452434760413351 2082 1245733
SGTC_2131 toluylene red 5.2905 µM 0.118681954627381 0.46239638176002 no 1540 0.452763666806029 2080 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1043 0916-0009 19.3 µM 0.117397398138811 0.46286857647694 no 1541 0.453272572900386 2239 3101130
SGTC_1996 st072960 66.8 µM 0.116633447519867 0.46314942467524 no 1542 0.453575265658187 2221 1719405
SGTC_1712 st032288 53.4 µM 0.115044223307119 0.463733723688973 no 1543 0.454205034796252 2144 2883011
SGTC_657 3534-0529 86.7 µM 0.113696502098835 0.464229292328808 no 1544 0.454739192731153 2209 1049549
SGTC_438 sphingosine 6.67 µM 0.113483824433946 0.464307500818895 no 1545 0.45482349323244 2036 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_3332 9141069 11.198 µM 0.113288170843283 0.464379450221553 no 1546 0.454901047581903 2152 17332883
SGTC_1604 st002052 72.4 µM 0.111739768520023 0.464948898618928 no 1547 0.455514873023469 2119 6254834 YHR062C RPP1
SGTC_1614 st002383 48.6 µM 0.111271667272397 0.46512106412573 no 1548 0.455700461050514 2242 1947235
SGTC_2281 7943571 200 µM 0.11046755045148 0.465416829853998 no 1549 0.45601929166203 2244 1244024
SGTC_1839 st053978 48 µM 0.109471620357336 0.465783173728736 no 1550 0.456414215068974 2217 3788398
SGTC_544 k015-0020 52.4 µM 0.107806334053661 0.46639579885577 no 1551 0.457074659164477 2125 3008304
SGTC_904 1141-0088 396 µM 0.107438688229619 0.466531059094727 no 1552 0.457220481674711 2035 1378119
SGTC_2819 7996655 46.38 µM 0.107348842284838 0.466564114822487 no 1553 0.457256118917439 2191 6456960
SGTC_626 0214-0009 33 µM 0.10529752949535 0.467318887164458 no 1554 0.458069861628132 2176 3437874
SGTC_2648 atorvastatin 78.68 µM 0.105026315410033 0.467418688157991 no 1555 0.458177463757858 2209 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3313 9133968 57.047 µM 0.104174447626018 0.4677321706075 no 1556 0.458515455731537 2225 1494643
SGTC_2924 9010168 62.78 µM 0.103965483065213 0.46780907142922 no 1557 0.458598370306312 2136 2993929
SGTC_263 alizarin 107.927 µM 0.103735303066709 0.467893781111579 no 1558 0.458689704991377 2223 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2649 anisomycin 9.56 µM 0.101844742848061 0.468589590211624 no 1559 0.459439955304102 2154 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1986 st071812 45 µM 0.101606579661367 0.468677251562112 no 1560 0.459534478333909 2224 11838594
SGTC_419 nsc-638432 893 µM 0.101276883463961 0.468798606213955 no 1561 0.459665333075658 2118 368090
SGTC_123 0083-0120 66.675 µM 0.101212882542831 0.468822164024012 no 1562 0.459690735222185 2059 16001701
SGTC_2240 6690706 185.951 µM 0.100400749863487 0.469121107728125 no 1563 0.460013087235512 2110 805876
SGTC_1219 1469-0211 33.1 µM 0.0987389627801479 0.469732860850446 no 1564 0.460672766090492 2230 6822282
SGTC_1094 duloxetine 25.4 µM 0.0965228415438548 0.470548791751809 no 1565 0.461552666846169 2206 60834 A selective serotonin reuptake inhibitor.
SGTC_1568 digitonin 820 nM 0.0960095143532318 0.470737806178614 no 1566 0.46175650805604 2249 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2682 pyrogallin 40.03 µM 0.0942455289393271 0.471387380872382 no 1567 0.462457059416918 2245 822798 An ATP competetive kinase inhibitor.
SGTC_1750 st081859 2.357 µM 0.0929222975686211 0.471874701187246 no 1568 0.462982645743663 2181 5291695
SGTC_2789 5281112 71.43 µM 0.0928812706712589 0.471889811270452 no 1569 0.462998942628591 2143 765948
SGTC_1098 clofazimine 15.1 µM 0.0928218370408301 0.471911700569974 no 1570 0.463022551227261 2216 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_3008 9078912 71.4286 µM 0.0920819861504913 0.472184193406931 no 1571 0.463316450304161 2182 16648731
SGTC_2783 7738165 71.43 µM 0.0907686576494619 0.472667934496737 no 1572 0.463838207394284 2130 17201110
SGTC_2589 lobaric acid 100 µM 0.0898419140832178 0.473009308236086 no 1573 0.464206420112096 2137 73157 A novel microtubule depolymerizer.
SGTC_444 curcumin 90.4 µM 0.088675461483461 0.47343900895061 no 1574 0.464669917296309 2217 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_2048 5246248 200 µM 0.0881773583692439 0.473622510862991 no 1575 0.46486785630648 2285 677046
SGTC_516 3992-2719 87.3 µM 0.087600351695471 0.473835087956471 no 1576 0.465097161321445 2230 5350887 YDR037W KRS1
SGTC_3218 9131285 49.47 µM 0.0867763577295694 0.47413867142425 no 1577 0.465424640259285 2232 17156417
SGTC_1934 st074720 32.6 µM 0.0856844639164288 0.474540980135444 no 1578 0.465858626350839 2239 17250992
SGTC_1676 st018489 23.4 µM 0.0847848125863039 0.474872476553544 no 1579 0.46621623393044 2089 3696235
SGTC_2073 5212005 126 µM 0.0840128255016698 0.475156946135833 no 1580 0.466523117272459 2283 691789
SGTC_1415 3966-0071 78.1 µM 0.0832560539332594 0.47543582124514 no 1581 0.466823971403321 2254 2893185
SGTC_268 camptothecin 39.6153 µM 0.0832455529909772 0.475439690993754 no 1582 0.466828146181028 2269 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2917 7979103 53.79 µM 0.0829327263880198 0.475554973167597 no 1583 0.466952515884951 2222 2980565
SGTC_859 0439-0102 54.6 µM 0.0822098735328732 0.475821365128418 no 1584 0.467239911040386 2273 610143
SGTC_763 3453-1109 128 µM 0.0815308696184452 0.476071607346324 no 1585 0.467509888092003 2263 1560353
SGTC_221 trifluoperazine 10.304 µM 0.080527223238069 0.476441511566413 no 1586 0.467908972761786 2252 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1350 1495-0454 146 µM 0.0797018649752556 0.476745721089614 no 1587 0.46823718806935 2254 1069057
SGTC_1557 sumaresinolic acid 42.3 µM 0.0794275922485858 0.476846815199387 no 1588 0.468346261262626 2238 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_3255 9139072 49.47 µM 0.0792415753455781 0.476915379967536 no 1589 0.468420238099075 2182 17646060
SGTC_1214 0358-0031 63.7 µM 0.0775031563566314 0.477556184043917 no 1590 0.469111640209515 2260 4301366
SGTC_912 3474-0017 2.18 µM 0.0773582692490632 0.477609593977877 no 1591 0.46916926878685 2237 3360550
SGTC_1702 st027038 51 µM 0.0768998423272908 0.477778587169985 no 1592 0.469351611490947 2176 5521182
SGTC_358 0075-0058 9.45 µM 0.0767151880777944 0.477846658716125 no 1593 0.469425060904847 2312 1069125
SGTC_188 3229-0966 278.469 µM 0.0747269594199809 0.47857964636406 no 1594 0.470215978561587 2272 5722370
SGTC_727 3032-0951 202 µM 0.0732669993698404 0.479117926851605 no 1595 0.470796825892844 2200 3652836
SGTC_58 0957-0393 9 µM 0.0708838876634451 0.4799966504509 no 1596 0.471745083448923 2259 6997992
SGTC_3044 9093193 49.47 µM 0.0683428977155312 0.480933695408714 no 1597 0.47275633824816 2198 25236277
SGTC_1772 st048439 82.2 µM 0.0677265126893344 0.481161016783754 no 1598 0.473001671844301 2161 2927068 YDL195W SEC31
SGTC_1286 0929-0070 131 µM 0.0671335464072511 0.481379707162177 no 1599 0.473237693977473 2238 1420408
SGTC_1893 st059353 36.1 µM 0.0669243713125097 0.481456853834465 no 1600 0.473320955514272 2146 3112488
SGTC_1941 st076221 61.8 µM 0.066876730229202 0.481474424623075 no 1601 0.473339919071724 2300 2828568
SGTC_375 3970-0961 9.27 µM 0.0666317378976624 0.481564782255874 no 1602 0.473437439347264 2225 2898222
SGTC_2321 7390090 138.78 µM 0.0655798766900638 0.481952738526219 no 1603 0.473856155346786 2193 649046
SGTC_2709 st078560 56 µM 0.0652974405301482 0.482056911924839 no 1604 0.473968590079194 2293 17250903
SGTC_778 3456-2434 196 µM 0.0645621891644851 0.482328106843572 no 1605 0.474261295273226 2286 5539063
SGTC_1810 st050138 53 µM 0.063729384241432 0.482635293923927 no 1606 0.474592853528246 2306 3444541
SGTC_866 0495-0101 262 µM 0.0637099641986911 0.48264245729327 no 1607 0.474600585292197 2128 635694
SGTC_3335 9143315 29.6265 µM 0.0588314050013668 0.484442157254649 no 1608 0.476543197099895 2195 4899691
SGTC_466 geldanamycin 89.2 µM 0.0586524315597581 0.484508186789475 no 1609 0.476614474091924 2309 5288382 HSP90 inhibitor.
SGTC_2147 5545932 89.7195 µM 0.0585970921241415 0.484528603520374 no 1610 0.476636513426919 2246 797404
SGTC_2414 st077232 92.9 µM 0.057843009275413 0.484806816134506 no 1611 0.476936839530719 2095 729801
SGTC_1121 fusaric acid 630.51 nM 0.0570191246919958 0.485110789970013 no 1612 0.477264980311602 2202 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_363 0455-0021 3.06 µM 0.0558293717395008 0.485549766882065 no 1613 0.477738868081701 2294 4597466
SGTC_71 0417-1750 47.813 µM 0.0542503749949195 0.486132387989878 no 1614 0.478367843151938 2317 6811472
SGTC_2172 5754775 163.918 µM 0.0536974444305022 0.48633641638288 no 1615 0.47858810945761 2259 2263357
SGTC_398 bronopol 33.3 µM 0.052178565695371 0.486896892682446 no 1616 0.479193205880566 2212 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_3283 9109332 35.8195 µM 0.0520752100392354 0.486935032556203 no 1617 0.479234382840405 2311 17027281
SGTC_3151 9099821 49.47 µM 0.0515974839831548 0.487111322582912 no 1618 0.47942471208098 2259 17174189
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.0515587795485744 0.487125605368261 no 1619 0.47944013239137 2274 2724 A muscle relaxant with antifungal properties.
SGTC_861 0443-0273 110 µM 0.0513357850953675 0.487207895534004 no 1620 0.47952897665152 2240 6149169
SGTC_1396 3511-0007 98.6 µM 0.0508705139054747 0.487379593228465 no 1621 0.479714350786017 2270 X1396
SGTC_2344 7990960 76.95 µM 0.0505566832316799 0.48749540658608 no 1622 0.47983939021422 2258 140813
SGTC_1492 4158-0558 28.5 µM 0.0502093094824917 0.487623599619338 no 1623 0.479977796509174 2306 3967268
SGTC_1332 1480-0653 17.5 µM 0.0498289376457225 0.487763971564458 no 1624 0.480129353206773 2327 5749438
SGTC_605 1315-0399 119 µM 0.0495658278211511 0.487861070171774 no 1625 0.480234189296259 2275 24020461
SGTC_2978 9011784 42.97 µM 0.0493094441405006 0.487955687240917 no 1626 0.480336346669496 2311 2994934
SGTC_78 0336-0123 156.75 µM 0.047631303749305 0.488575012755855 no 1627 0.481005041775575 2181 6765896
SGTC_1979 st071809 45.3 µM 0.0476046911483621 0.488584834485847 no 1628 0.481015646637342 2295 4976333
SGTC_2251 lansoprazole 556 µM 0.0472217044033613 0.48872618153919 no 1629 0.481168264601924 2164 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_170 4197-0004 226 µM 0.0470775104285254 0.488779398875323 no 1630 0.481225725768962 2275 218692
SGTC_2885 9057732 51.95 µM 0.0460987442381709 0.489140635076909 no 1631 0.481615773449406 2276 6471414
SGTC_147 4466-0538 29.23 µM 0.0453601780169424 0.489413225861831 no 1632 0.481910110817557 2226 6742687 YHR072W ERG7
SGTC_2431 5490079 200 µM 0.0447800899934814 0.489627328823289 no 1633 0.482141297527205 2300 5722345
SGTC_540 1187-0821 17.3 µM 0.0442911961085325 0.48980777553524 no 1634 0.482336144638585 2300 847520
SGTC_3200 9114385 49.47 µM 0.0441256285141292 0.489868885647312 no 1635 0.482402132038316 2261 17018030 YLR208W SEC13
SGTC_1915 st067105 30.6 µM 0.0440491745731074 0.489897104467696 no 1636 0.482432603120186 2330 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_1609 st001574 46.4 µM 0.0435349822551897 0.49008689194463 no 1637 0.482637539571519 2324 3960012
SGTC_3302 9125395 16.351 µM 0.0424445841022334 0.490489363351495 no 1638 0.483072143689487 2255 17599668
SGTC_1844 rapamycin 4 nM 0.0406620835346954 0.491147313885057 no 1639 0.483782644768031 2293 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_3003 9075612 71.4286 µM 0.0405133438361 0.491202217289182 no 1640 0.483841934466589 2290 6501993
SGTC_2047 4141938 200 µM 0.040047740357214 0.491374083816874 no 1641 0.484027532748797 2281 3807862
SGTC_441 propafenone 146 µM 0.0393634197979357 0.491626687486629 no 1642 0.484300322032484 2336 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2259 7964009 200 µM 0.0390274555831208 0.491750703399578 no 1643 0.484434249447164 2291 313134
SGTC_2135 5326629 150.42 µM 0.038807111729178 0.491832040306084 no 1644 0.484522087383667 2291 5020077
SGTC_3040 9091894 49.47 µM 0.0387774240093398 0.491842999146036 no 1645 0.484533922162243 2293 25236966
SGTC_816 0325-0417 81.3 µM 0.0387541920667104 0.491851574923156 no 1646 0.484543183404957 2277 68101
SGTC_1905 st060207 84.5 µM 0.0385486011461909 0.491927466368971 no 1647 0.484625141073076 2285 1948547
SGTC_3145 9085516 49.47 µM 0.0377372338244609 0.492226975802308 no 1648 0.484948594414935 2223 25236195
SGTC_1780 st038448 24.544 µM 0.0355105552149879 0.493048957524193 no 1649 0.485836314920128 2309 728868 YDL195W SEC31
SGTC_3259 9138485 49.47 µM 0.0351929606644173 0.493166200511563 no 1650 0.485962937665932 2337 17646153
SGTC_510 ag-490 170 µM 0.0349851631391436 0.493242911224183 no 1651 0.486045785865573 2335 5328779
SGTC_1193 1488-0126 41.5 µM 0.0337957270687057 0.493682009186745 no 1652 0.486520021653054 2349 1384710
SGTC_2777 climbazole 1.536 µM 0.0334985144298127 0.493791730855715 no 1653 0.486638525240894 2358 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_353 1988-1175 58.3 µM 0.0334982962440458 0.493791811403293 no 1654 0.486638612235597 2302 2788357
SGTC_518 1021-0119 62.6 µM 0.033428071300696 0.49381773633879 no 1655 0.486666612253248 2204 1097762
SGTC_333 3486-0131 40.1 µM 0.0331234879358185 0.493930179650754 no 1656 0.486788056180255 2337 6744690
SGTC_920 mycophenolic acid 780.421 nM 0.0325414409253328 0.494145055797608 no 1657 0.487020134218264 2319 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_950 1165-0508 94.1 µM 0.0316717891172732 0.494466111068911 no 1658 0.487366896309534 2308 6148369
SGTC_1742 st038235 28.8875 µM 0.0309745834197101 0.494723505835767 no 1659 0.48764490471848 2297 564103 YBR002C RER2
SGTC_1696 st025591 34.7925 µM 0.0299779637573031 0.495091442195714 no 1660 0.488042313822559 2366 2787147
SGTC_2070 5230947 200 µM 0.0299196468006304 0.495112972034512 no 1661 0.488065568490982 2352 2835538
SGTC_2256 7954252 200 µM 0.0294626572972315 0.495281686922152 no 1662 0.488247800581625 2247 2972920
SGTC_374 0880-0231 82.3 µM 0.0292066633040088 0.495376197117462 no 1663 0.488349883477018 2335 6833587
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.0283661374325329 0.495686511915046 no 1664 0.488685065870692 2344 4620898
SGTC_2638 epoxomicin 18 µM 0.0271615076061822 0.496131255210693 no 1665 0.489165458425478 2358 9915668 A protesome inhibitor.
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.0254401451198367 0.49676678182264 no 1666 0.489851945142469 2361 5355888
SGTC_1259 0671-0132 43 µM 0.0249915472264007 0.496932405469105 no 1667 0.490030852920255 2333 X1259
SGTC_2220 6782180 200 µM 0.0244701546081338 0.497124905802072 no 1668 0.490238794878084 2356 833803
SGTC_2736 butenafine 14.65 µM 0.0242922978001764 0.49719057143401 no 1669 0.4903097283924 2346 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1781 st038725 66.3 µM 0.024282526769057 0.497194178950279 no 1670 0.490313625320311 2339 4270275 YIL048W NEO1
SGTC_1967 st070177 51.4 µM 0.0241139612684197 0.497256414258822 no 1671 0.49038085353966 2344 5729214
SGTC_2128 5255449 168.493 µM 0.0240193726753084 0.497291336916192 no 1672 0.490418578002011 2365 736008
SGTC_2398 5228213 48.84 µM 0.0206491174180493 0.498535666240782 no 1673 0.491762779385786 2373 80771 YMR134W ERG29
SGTC_2656 pseudo-anisatin 100 µM 0.0204677211795176 0.498602639917352 no 1674 0.491835130723532 2362 6708809 A neurotoxin.
SGTC_2874 9043904 71.43 µM 0.0201495016002329 0.498720130513653 no 1675 0.491962055790457 2282 4463428
SGTC_2326 6164455 177.58 µM 0.018636882179387 0.499278609616946 no 1676 0.492565390107634 2368 2888790
SGTC_2627 acetyl isogambogic acid 100 µM 0.0183342609965519 0.499390341566303 no 1677 0.492686097866282 2346 6857789 A caspase activator and apoptosis inducer.
SGTC_1288 0973-0013 65.5 µM 0.0167171071671977 0.499987417845885 no 1678 0.493331149761123 2350 4315430
SGTC_857 0438-0306 1.35 µM 0.0166489508149153 0.499987417845885 no 1679 0.493358336428114 2309 4686136
SGTC_2294 7971431 200 µM 0.0164808745956723 0.499925361682128 no 1680 0.493425379939343 2366 5741572
SGTC_1130 3454-2858 15.9 µM 0.0159255376509132 0.49972032329536 no 1681 0.493646898242583 2321 715628 YIL048W NEO1
SGTC_2345 9052315 157.45 µM 0.0147211633136432 0.499275651295274 no 1682 0.494127317652351 2357 6469265
SGTC_696 1560-0013 611 µM 0.0139275992094294 0.498982656687625 no 1683 0.494443871439256 2365 1650269
SGTC_1470 k295-0292 231 µM 0.0137696482678468 0.498924339122675 no 1684 0.494506878705823 2383 5045612
SGTC_1776 st049249 45.9 µM 0.0132774477553821 0.498742612373269 no 1685 0.494703220343775 2371 1822314
SGTC_1845 st056753 3.01 µM 0.0129237336507203 0.498612016742825 no 1686 0.494844319745918 2369 5375839
SGTC_1188 1403-0014 4.57 µM 0.0119743014204436 0.498261475372926 no 1687 0.495223059041453 2381 9614867
SGTC_1798 st045719 60.953 µM 0.0112753800188052 0.498003426343381 no 1688 0.49550186949414 2382 3980186
SGTC_776 4476-4378 112 µM 0.00901790532961932 0.497169949532102 no 1689 0.496402425044125 2310 2892008
SGTC_2086 5274770 176.623 µM 0.00836718213452672 0.496929699716531 no 1690 0.496662016227324 2382 689278
SGTC_1513 0337-0559 19 µM 0.00730533240589994 0.496537662638662 no 1691 0.497085619953304 2388 775073
SGTC_2450 5739737 12.93 µM 0.00699177737534722 0.496421898106574 no 1692 0.497210707115579 2384 2262825
SGTC_367 0335-0881 7.1 µM 0.00672946017508819 0.496325050814915 no 1693 0.497315354074544 2388 23828853
SGTC_74 000s-0487 160.283 µM 0.00586002162068067 0.496004056405499 no 1694 0.497662202991386 2389 677548
SGTC_2922 7999257 32.47 µM 0.0054192806625393 0.495841336987265 no 1695 0.497838030396694 2401 2988377
SGTC_2674 ligustilide 100 µM 0.00475631720641063 0.495596575415234 no 1696 0.498102511121705 2393 5319022 A signalling regulator.
SGTC_1497 4476-2978 41.3 µM 0.00420964348439495 0.495394748460327 no 1697 0.498320600188795 2385 1528379
SGTC_1012 4112-3522 18 µM 0.000847882338242938 0.494153644751316 no 1698 0.499661743926998 2401 3112398
SGTC_1662 st014054 52 µM -0.000219109046287349 0.493759741360587 no 1699 0.499912588138117 2408 2838777
SGTC_783 0848-0141 92.7 µM -0.00137157342684576 0.493334290575849 no 1700 0.499452821540916 2408 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2194 5927483 104.545 µM -0.00178499873452742 0.493181669788607 no 1701 0.499287888912491 2398 760979
SGTC_1046 2001-0062 216 µM -0.00184242275560252 0.493160471118103 no 1702 0.499264980080257 2407 739778
SGTC_395 anisomycin 6.25 µM -0.00291432721945292 0.492764770123855 no 1703 0.498837353299021 2419 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2037 5169046 200 µM -0.00361889440790894 0.492504678095458 no 1704 0.498556273163647 2419 5718022
SGTC_2183 6420625 130.508 µM -0.00376406947835401 0.492451086893993 no 1705 0.498498357084651 2412 2897619
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.00457467593479866 0.492151855033731 no 1706 0.498174974716061 2422 616764
SGTC_2264 7948757 110.76 µM -0.00551158546888618 0.49180600445285 no 1707 0.497801206656755 2412 2971411
SGTC_1924 st058459 75.1 µM -0.0058036923385959 0.491698177434165 no 1708 0.49768467474149 2420 688683
SGTC_2603 homopterocarpin 100 µM -0.00650971624188693 0.491437561460144 no 1709 0.497403017299507 2420 101795 A weak amylase inhibitor.
SGTC_412 gemfibrozil 100 µM -0.00886641088567935 0.490567657282317 no 1710 0.49646286016669 2419 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2409 alverine citrate 63.97 µM -0.0103463534035269 0.490021402909971 no 1711 0.495872475819356 2498 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_1424 4048-1941 275 µM -0.0107770818888832 0.489862422288037 no 1712 0.495700649600366 2437 X1424
SGTC_2583 asiatic acid 100 µM -0.0107981196356266 0.489854657358402 no 1713 0.49569225724204 2442 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_387 norethindrone acetate 66.7 µM -0.0122601232800214 0.489315048532496 no 1714 0.495109040988155 2439 541197
SGTC_2833 9001315 45.46 µM -0.013741873267058 0.488768171516887 no 1715 0.494517958279682 2449 2989378
SGTC_1077 5-fluorocytosine 377 nM -0.0144243365902077 0.488516298342338 no 1716 0.494245721808729 2440 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1634 st006576 41 µM -0.0146170817324042 0.488445163724359 no 1717 0.494168835728464 2440 3915356
SGTC_3083 9117465 49.47 µM -0.0148617422952432 0.488354869705144 no 1718 0.494071240887672 2476 16420915
SGTC_3124 9127567 49.47 µM -0.0152802198715026 0.488200428455011 no 1719 0.493904311449112 2433 17592030
SGTC_3242 9133940 49.47 µM -0.0155587007002784 0.488097654686345 no 1720 0.493793226879096 2458 17248444
SGTC_2045 5106652 78.05 µM -0.0161103782833015 0.487894059585016 no 1721 0.493573166958701 2436 673349
SGTC_192 3455-0609 60.9 µM -0.0166908387600448 0.487679845642571 no 1722 0.493341627877456 2469 3769639
SGTC_1673 st016611 27.3 µM -0.0175658022201758 0.487356954645706 no 1723 0.492992619170266 2462 5226799
SGTC_2203 7227154 166.4 µM -0.018220503369076 0.487115353272024 no 1724 0.492731473013871 2439 896304
SGTC_1728 st035614 33.7865 µM -0.0185677587035007 0.486987209136151 no 1725 0.492592961613806 2526 15945546
SGTC_2060 5238662 140 µM -0.0198658948598158 0.486508183041006 no 1726 0.492075175866136 2464 790130
SGTC_1491 4138-0063 26.5 µM -0.0201933109162894 0.486387366068924 no 1727 0.491944581957296 2445 23883227
SGTC_930 2810-3379 265 µM -0.0206551333787223 0.486216955076071 no 1728 0.491760379876479 2442 1015764
SGTC_2179 6298986 200 µM -0.0207401331677024 0.486185590702567 no 1729 0.491726477129451 2462 738374
SGTC_767 0929-0023 86 µM -0.0220343624443525 0.485708039122972 no 1730 0.491210272459699 2441 1204563
SGTC_1757 st041620 31.8375 µM -0.0222160417184737 0.485641003766084 no 1731 0.491137810653967 2465 5289815
SGTC_537 1334-0398 209 µM -0.0246682624635816 0.484736232759049 no 1732 0.490159785129154 2446 5846986
SGTC_68 0986-0284 82.829 µM -0.0254449577777286 0.484449679534343 no 1733 0.489850025791076 2591 423278 YIL048W NEO1
SGTC_2239 6685329 187.64 µM -0.0257010400857884 0.484355202526239 no 1734 0.48974789713183 2548 805680
SGTC_2887 9044784 58.44 µM -0.0273418466429737 0.48374987723025 no 1735 0.489093540269101 2462 6465546
SGTC_2816 7982706 58.44 µM -0.0287226280738709 0.483240509198044 no 1736 0.488542904609049 2494 2981853
SGTC_828 2074-0507 139 µM -0.0287785444464626 0.483219882309474 no 1737 0.488520606421562 2500 X828
SGTC_1679 SEC14.276 6.7 µM -0.0290470426957994 0.483120837107172 no 1738 0.488413535880153 2468 1005053 YMR079W SEC14
SGTC_1881 5652484 16 µM -0.0290554287577492 0.483117743624406 no 1739 0.488410191736959 2439 2255129
SGTC_2909 7941780 10.49 µM -0.0292010518993878 0.483064025762403 no 1740 0.488352121149154 2452 1243215
SGTC_1358 1509-0022 2.48 µM -0.0293185350812632 0.483020688469586 no 1741 0.488305272199512 2486 3258434
SGTC_1440 4100-1550 40 µM -0.0302795904691403 0.482666181145802 no 1742 0.48792203677749 2462 742806
SGTC_2064 5220758 200 µM -0.0305073022271568 0.482582186438558 no 1743 0.487831234879009 2498 788518
SGTC_1278 0874-0585 172 µM -0.0318223398645771 0.482097131419495 no 1744 0.487306865510573 2482 766306
SGTC_2504 purpurogallin 52.29 µM -0.0321130304072673 0.481989913015466 no 1745 0.487190956003992 2499 5281571 An antioxidant.
SGTC_2301 7769476 200 µM -0.0336653275025778 0.48141738543854 no 1746 0.486572013967789 2480 977820
SGTC_318 1488-0629 67.2 µM -0.033809249613102 0.481364305141022 no 1747 0.486514630019498 2521 3662576
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.0342394151445922 0.481205656617006 no 1748 0.486343118107302 2468 140250 A respiratory chain inhibitor.
SGTC_1749 st037932 54.2 µM -0.0343347438506789 0.481170499021912 no 1749 0.486305109803843 2515 594497
SGTC_1430 4049-0248 69.1 µM -0.0343396993502997 0.481168671418509 no 1750 0.486303134010642 2476 22774488
SGTC_1800 st050079 29.0735 µM -0.0346462383050052 0.481055619686305 no 1751 0.486180915388841 2463 3645560
SGTC_2810 7959871 45.46 µM -0.0365256511614927 0.480362524854361 no 1752 0.485431612841688 2505 2974535
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.0378485260094774 0.479874707051368 no 1753 0.484904226953255 2449 368090
SGTC_1849 st056239 19.2 µM -0.0379290859125336 0.479845001084285 no 1754 0.484872111262132 2483 5393181
SGTC_749 1000-0129 128 µM -0.0394737043623874 0.479275454405556 no 1755 0.484256359025508 2505 708470
SGTC_3143 9086658 49.47 µM -0.0396462908777455 0.479211819240318 no 1756 0.484187560823025 2535 25236626
SGTC_98 0074-0023 107.663 µM -0.0405404742637256 0.478882129305672 no 1757 0.483831119876677 2519 3563821
SGTC_308 4092-1169 104 µM -0.0406174667433203 0.478853742461641 no 1758 0.483800429599822 2472 2268590 YDL196W YDL196W
SGTC_585 0kpi-0023 191 µM -0.0414244154669245 0.47855622991633 no 1759 0.483478774385906 2499 64601
SGTC_2551 apiole 73.87 µM -0.0414657548576106 0.478540988887379 no 1760 0.483462296513176 2472 10659 A possible DNA adduct former.
SGTC_2094 5332512 191.667 µM -0.0415672389441025 0.478503573812518 no 1761 0.483421845096755 2515 755774
SGTC_418 lividomycin a 100 µM -0.0418837098728621 0.478386898772203 no 1762 0.483295701320207 2482 72394 An antibiotic.
SGTC_1429 4049-0205 9.46 µM -0.0419593542492066 0.478359010826817 no 1763 0.483265550085973 2480 22774478
SGTC_235 0330-0087 5 mM -0.0428869810251708 0.478017029688866 no 1764 0.482895813419784 2485 46494818 YHR062C RPP1
SGTC_167 3672-0051 66.205 µM -0.0430720934217944 0.477948787632794 no 1765 0.482822032435346 2474 3237971
SGTC_2161 5662504 8.5105 µM -0.0434159937109746 0.477822009819667 no 1766 0.482684964292316 2517 2859334
SGTC_2642 cholecalciferol 100 µM -0.0440029501260998 0.477605635283631 no 1767 0.48245102614321 2487 9821465 A vitamin D precursor, similar to steriods.
SGTC_1009 4106-0057 9.87 µM -0.0447677957933766 0.47732369389518 no 1768 0.482146197289677 2471 2928005
SGTC_2884 9058502 51.95 µM -0.0453731445180898 0.477100555138781 no 1769 0.481904943252528 2519 6471554
SGTC_231 b-estradiol 524 µM -0.0495542107372128 0.475559564082783 no 1770 0.480238818154035 2487 450 A steroid.
SGTC_447 ml7 120 µM -0.0496225194840062 0.475534390900409 no 1771 0.480211600391724 2495 4216 Selective myosin light chain kinase inhibitor.
SGTC_1813 st051246 8.6015 µM -0.049703119301491 0.475504688330527 no 1772 0.48017948534538 2506 5291959
SGTC_2113 5491891 107.031 µM -0.0497979398999935 0.475469745305917 no 1773 0.480141704184905 2506 789979
SGTC_682 0kpi-0099 17 µM -0.0506277378093919 0.475163958555785 no 1774 0.479811079793431 2547 1714895 YML126C ERG13
SGTC_2737 bleomycin 30.5 nM -0.0521700432162806 0.47459564645073 no 1775 0.479196601233319 2500 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_349 k015-0014 24 µM -0.052189933089468 0.474588317721415 no 1776 0.479188677116998 2502 2196908
SGTC_1975 st070967 30.8 µM -0.0524283074198396 0.474500485707363 no 1777 0.479093709534435 2503 261391
SGTC_1210 3013-0140 750 nM -0.0525900036926439 0.474440907391288 no 1778 0.479029290923808 2536 905973
SGTC_2722 naftopidil 47.16 µM -0.052750509462744 0.474381768290978 no 1779 0.478965347142488 2499 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1405 3909-7894 12 µM -0.0529985141397885 0.474290390920379 no 1780 0.478866545798055 2542 7104060
SGTC_3185 9108267 49.47 µM -0.0530154761103663 0.474284141328443 no 1781 0.478859788450704 2541 4910486
SGTC_1831 st055328 12 µM -0.0533627887220677 0.47415617633469 no 1782 0.478721426623168 2506 1103068
SGTC_1912 st060209 90.8 µM -0.0537807061934177 0.474002200991459 no 1783 0.478554940748408 2546 688787
SGTC_1552 6-methylflavone 10.6 µM -0.0543712274978764 0.473784639014375 no 1784 0.478319701032746 2519 689013
SGTC_85 0868-0259 160.055 µM -0.0545296472450493 0.473726274770343 no 1785 0.478256594317966 2578 83173
SGTC_858 0438-0351 2.77 µM -0.0554162032819748 0.47339966448841 no 1786 0.477903443660409 2524 2799119
SGTC_999 SEC7.066 22.7 µM -0.055547292202574 0.473351372393028 no 1787 0.477851227176432 2530 740511 YDR170C SEC7
SGTC_2566 crystal violet carbinol 226 nM -0.0559762770428353 0.473193340598082 no 1788 0.47768035285024 2628 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_2424 5537928 59.2 µM -0.0562640817278928 0.473087319888448 no 1789 0.477565716058309 2523 5382802
SGTC_2374 9071832 200 µM -0.0564311740135094 0.473025767759514 no 1790 0.47749916162184 2501 17381698
SGTC_394 menadione 8.33 µM -0.0574680900494028 0.472643811323574 no 1791 0.477086162267954 2494 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1514 1189-1591 158 µM -0.0576901197821298 0.472562028127562 no 1792 0.476997731930716 2540 767698 YMR146C TIF34
SGTC_693 4161-2696 114 µM -0.058270347033034 0.472348310694622 no 1793 0.476766643503797 2577 805759
SGTC_2526 patulin 37.61 µM -0.0589740676001034 0.472089117161218 no 1794 0.476486381604614 2574 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1356 1502-0781 85.8 µM -0.0601984158223507 0.47163819489589 no 1795 0.475998803709575 2501 567702
SGTC_2658 polymyxin b sulfate 77.05 µM -0.0607144367662625 0.471448157423961 no 1796 0.475793317007934 2533 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_151 3013-0144 2.285 µM -0.061243372309332 0.471253370578757 no 1797 0.475582694215618 2719 906558 YHR107C CDC12
SGTC_2464 5717415 7.67 µM -0.0616590247722518 0.471100306406698 no 1798 0.475417185671405 2522 5285744
SGTC_143 4032-1194 15.74 µM -0.061689606983716 0.47108904466443 no 1799 0.475405008315894 2494 1806963
SGTC_1520 flindersine 88 µM -0.062191346214149 0.470904285077993 no 1800 0.475205226935938 2711 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_1027 k015-0025 8.67 µM -0.0625485638108415 0.470772747702223 no 1801 0.475062994645886 2519 3598955
SGTC_1030 k029-0042 36.7 µM -0.0626891710292774 0.470720973118424 no 1802 0.475007010349877 2572 6080581
SGTC_734 2023-0417 80 µM -0.0637415256181603 0.470333489434313 no 1803 0.474588019647819 2581 3935732
SGTC_2759 disulfiram 3.38 µM -0.0641812080289433 0.470171603859474 no 1804 0.474412970180711 2542 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_493 zm226600 134 µM -0.06455608069594 0.470033584315616 no 1805 0.474263727126474 2640 5240098 A potassium channel opener. YCR052W RSC6
SGTC_2285 7945142 200 µM -0.0651571564959182 0.469812289471812 no 1806 0.474024436383358 2591 2970608
SGTC_722 3534-0461 190 µM -0.0664017756457961 0.469354094453745 no 1807 0.473528978282023 2564 658262
SGTC_1039 k821-0043 94 µM -0.0666338860806017 0.469268649617503 no 1808 0.473436584246666 2503 15992768
SGTC_1825 st052143 62.6 µM -0.0672088915476635 0.469056983859487 no 1809 0.473207703350168 2551 674173
SGTC_1016 4226-1401 38 µM -0.067580043844382 0.468920363308165 no 1810 0.473059970890108 2519 2901613
SGTC_2940 9060638 45.86 µM -0.0678969779290622 0.468803703287871 no 1811 0.472933822233332 2579 4027022
SGTC_3131 9127911 49.47 µM -0.069738326238002 0.4681259761266 no 1812 0.47220096805025 2674 45595681
SGTC_1299 1079-1439 3.74 µM -0.0697420156383392 0.468124618296973 no 1813 0.472199499767448 2538 323161
SGTC_251 melphalan 456.522 µM -0.0697429159622855 0.468124286946019 no 1814 0.47219914146262 2565 460612 A DNA alkylator.
SGTC_1204 4049-0315 18.3 µM -0.0704930948438807 0.467848202366761 no 1815 0.471900598197828 2774 588402
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.0705935218618382 0.467811243884745 no 1816 0.471860633178232 2609 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1401 3807-4679 7.6 µM -0.0714738468247393 0.467487284468504 no 1817 0.471510319261363 2530 3291456
SGTC_1622 st003707 19.4 µM -0.0727058886181285 0.467033929531274 no 1818 0.471020081257139 2636 10140899
SGTC_2817 7995342 71.43 µM -0.0733182870798066 0.466808600885516 no 1819 0.470776419939016 2540 18879975
SGTC_1385 3091-4834 14.1 µM -0.0739319964847727 0.466582800556791 no 1820 0.470532247997679 2604 4072814
SGTC_2939 9044578 71.43 µM -0.0739352081427337 0.46658161892898 no 1821 0.470530970228561 2549 2653634
SGTC_3062 9077494 49.47 µM -0.0745605293755436 0.466351557414257 no 1822 0.470282189831509 2570 16459633
SGTC_1809 st050081 57.6 µM -0.0757726964680043 0.465905621922052 no 1823 0.469799969360471 2644 5036894
SGTC_899 1083-0020 478 µM -0.0758222667675705 0.465887386765876 no 1824 0.469780250398826 2692 767123
SGTC_1555 citronellol 128 µM -0.0780696090552525 0.465060745014449 no 1825 0.468886340924885 2545 8842 A terpine precursor.
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.0790860695542601 0.464686908818387 no 1826 0.468482081845471 2587 5024745
SGTC_220 paclitaxel 373.376 µM -0.0793307838203469 0.46459691188175 no 1827 0.468384760752753 2623 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_638 3970-0837 4.09 µM -0.0795361301689677 0.464521394419404 no 1828 0.468303097453531 2575 4118451 YLR208W SEC13
SGTC_847 0342-0274 5.54 µM -0.0800094905141946 0.46434731793045 no 1829 0.468114853916442 2597 18097
SGTC_1583 clindamycin 39.6 µM -0.0811239880052265 0.463937492671647 no 1830 0.467671674444181 2566 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1207 2099-0101 141 µM -0.0818535277196809 0.463669245553945 no 1831 0.467381594938459 2604 5837381
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.0821191484069791 0.463571582609927 no 1832 0.467275983161683 2516 2333 A French combination drug.
SGTC_108 0509-0257 621.132 µM -0.0827805667615566 0.463328403032185 no 1833 0.467013010780948 2567 536624
SGTC_1579 chlormadinone acetate 49.4 µM -0.0827855535183182 0.463326569634234 no 1834 0.467011028157979 2578 45114258 A steroidal progestin.
SGTC_321 4534-3890 65.3 µM -0.0835633680194869 0.46304061306848 no 1835 0.466701796557682 2587 699746
SGTC_1775 st081588 35.1725 µM -0.0843802233372034 0.462740324056258 no 1836 0.466377065346562 2565 1426443 YGL099W LSG1
SGTC_2101 5377231 179.231 µM -0.0849022650501033 0.462548424326078 no 1837 0.466169545521023 2616 2844213
SGTC_1998 st075797 76.8 µM -0.0880231733374723 0.46140137855184 no 1838 0.464929128983844 2541 24208315
SGTC_2137 5261020 140 µM -0.0886072478086712 0.461186745601018 no 1839 0.464697023913547 2564 763655
SGTC_712 r015-0009 80.6 µM -0.0886620703676806 0.46116660024323 no 1840 0.464675238618887 2636 6813872 YLR060W FRS1
SGTC_2468 5987765 72.9 µM -0.090500277954145 0.460491181767909 no 1841 0.463944836542721 2643 26772094
SGTC_1063 disulfiram 1.84 µM -0.0912008636319138 0.460233793229251 no 1842 0.463666494367997 2568 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_1877 wortmannin 25 µM -0.0916816787235726 0.460057155956399 no 1843 0.463475477168144 2603 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1623 st003709 20.3 µM -0.0920191709394206 0.459933175984084 no 1844 0.463341404003238 2560 16192618
SGTC_2773 thioridazine 9.09 µM -0.0926989681169213 0.459683459884438 no 1845 0.463071358403099 2547 5452 An antipsychotic.
SGTC_922 1866-0035 480 µM -0.0936365196959206 0.459339086620907 no 1846 0.462698949262517 2583 3156169
SGTC_2191 5911152 200 µM -0.0937109638901857 0.459311743733133 no 1847 0.462669380341147 2583 2875902
SGTC_827 3253-0474 693 µM -0.0953892611729899 0.458695366944144 no 1848 0.462002822762877 2587 5402065
SGTC_1478 0453-0656 35.7 µM -0.0954357938084786 0.458678278628551 no 1849 0.461984343233553 2585 5258496
SGTC_2359 9039622 200 µM -0.0969412155850857 0.458125479567668 no 1850 0.461386538811413 2601 6463596
SGTC_604 1000-0114 314 µM -0.0993498239648154 0.457241194357272 no 1851 0.460430260128609 2620 1572745
SGTC_1937 st074714 47.2 µM -0.101354627665323 0.456505321324164 no 1852 0.459634476403848 2579 17250970
SGTC_3329 9141233 27.5565 µM -0.101572896510346 0.456425213631412 no 1853 0.459547846804212 2695 4909101 YNL103W MET4
SGTC_1559 coumarin 343 70.1 µM -0.102585628478253 0.456053550179234 no 1854 0.45914592473448 2679 108770 A hepatotoxic, DNA x-linker.
SGTC_184 1494-0393 24.714 µM -0.103164804143549 0.455841015221422 no 1855 0.458916086525138 2578 3090647
SGTC_48 0382-0018 55 µM -0.104570963399447 0.455325062127483 no 1856 0.458358128100723 2669 762596
SGTC_62 0180-0423 3.232 µM -0.10499668291458 0.455168870385611 no 1857 0.458189220411383 2619 30102 YGL099W LSG1
SGTC_2440 5628896 157.78 µM -0.10565013525421 0.454929139500749 no 1858 0.457929972565404 2610 5522048
SGTC_2114 5491910 81.25 µM -0.10723840413377 0.454346522755728 no 1859 0.457299924495002 2693 2849228
SGTC_1373 2887-0003 58.5 µM -0.107795061506377 0.454142350088869 no 1860 0.457079130205611 2689 776948
SGTC_1483 3453-0561 55.9 µM -0.110405525586048 0.4531850378058 no 1861 0.456043885568608 2678 4546991
SGTC_853 0419-0306 21 µM -0.11141017982167 0.452816682070458 no 1862 0.455645543993352 2600 762713
SGTC_66 0109-0187 42.4 µM -0.113893524783744 0.451906340340636 no 1863 0.454661099320192 2571 759417
SGTC_1179 1021-1431 9.29 µM -0.114472154114878 0.45169426320892 no 1864 0.454431759536105 2685 2840958
SGTC_535 2293-4129 48.2 µM -0.115216044708798 0.451421635377392 no 1865 0.454136940764713 2624 396118 YIL048W NEO1
SGTC_1664 st014217 9.02 µM -0.115281032741959 0.451397819054713 no 1866 0.454111185900738 2627 3982782
SGTC_1527 coumarin 137 µM -0.115425833779085 0.451344754095502 no 1867 0.454053801706652 2835 323 A hepatotoxic, DNA x-linker.
SGTC_2820 7989630 71.43 µM -0.115555915453363 0.451297084054394 no 1868 0.454002251567393 2616 2984098
SGTC_3142 9086498 49.47 µM -0.116111979332812 0.451093315483457 no 1869 0.453781897449044 2664 25236367
SGTC_178 4092-0806 87.505 µM -0.116348678612308 0.451006581381572 no 1870 0.453688103795679 2606 2169044
SGTC_3005 9076496 71.4286 µM -0.116716473437722 0.450871814368502 no 1871 0.453542367793068 2641 21368410
SGTC_2986 9022445 71.43 µM -0.119457662325876 0.449867570108977 no 1872 0.452456390179816 2639 6459286
SGTC_1272 0839-0021 27 µM -0.120275267684382 0.449568099341792 no 1873 0.452132547698757 2690 5027250
SGTC_478 N-arachidonylglycine 10 µM -0.121831455577829 0.448998181618926 no 1874 0.451516250778517 2625 5283389
SGTC_817 1391-0715 46 µM -0.122583202773205 0.448722909260754 no 1875 0.451218578180245 2684 1353946
SGTC_1248 0469-0687 58.6 µM -0.123316995669613 0.448454235154508 no 1876 0.450928041477239 2716 4017482
SGTC_500 h-89 112 µM -0.124506496723489 0.448018756365448 no 1877 0.450457128382835 2800 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_2751 anetholtrithion 17.25 µM -0.125019862780089 0.447830831313331 no 1878 0.450253912742722 2733 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_2235 salicylic acid 500 µM -0.125586640500585 0.447623367752214 no 1879 0.450029569278327 2628 338 A COX inhibitor and kinase inhibitor.
SGTC_1703 st026983 48.3 µM -0.125770266793479 0.447556156175109 no 1880 0.44995688925213 2658 1104023
SGTC_2621 lithochol-11-enic acid 100 µM -0.125780373059364 0.447552457085871 no 1881 0.449952889200104 2619 6708711
SGTC_2636 apigenin dimethyl ether 100 µM -0.125944456039992 0.447492400172468 no 1882 0.449887945998183 2736 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2671 danthron 100 µM -0.127181741415235 0.447039573412634 no 1883 0.449398278130461 2666 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.127805468114709 0.446811325500568 no 1884 0.449151461312935 2670 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3194 9111903 49.47 µM -0.1300652546218 0.445984522377733 no 1885 0.448257399677921 2785 17087251
SGTC_1434 4073-0095 163 µM -0.130579286677965 0.445796482703036 no 1886 0.448054064622357 2649 24133745
SGTC_2022 5136654 200 µM -0.130727551140742 0.445742247879538 no 1887 0.447995418356915 2772 1713771
SGTC_1240 0356-0016 42.1 µM -0.131145442514894 0.445589389575104 no 1888 0.447830126820055 2715 4305613
SGTC_3254 9136651 49.47 µM -0.13202666234597 0.445267079310092 no 1889 0.447481601420623 2639 16454030
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -0.132588114925443 0.445061744262692 no 1890 0.447259566171598 2629 6312947
SGTC_517 1365-0151 113 µM -0.132942391176317 0.444932185548338 no 1891 0.447119470559375 2793 768657
SGTC_2739 tacrine 100.86 µM -0.133358581084177 0.44477999254399 no 1892 0.446954900133551 2730 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_602 3130-1533 38.1 µM -0.133515156949457 0.444722737732225 no 1893 0.44689298903749 2743 720941
SGTC_2187 6125751 200 µM -0.134236383957292 0.444459022873845 no 1894 0.446607828011654 2674 874498
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.134997622666506 0.444180704507458 no 1895 0.446306876981406 2727 1273210
SGTC_2720 fluspirilene 36.88 µM -0.136672619535388 0.443568401862437 no 1896 0.4456447864262 2732 3396 An atypical antipsychotic.
SGTC_2382 9035899 200 µM -0.136869521202901 0.443496432391674 no 1897 0.445566965314203 2680 6462679
SGTC_105 0111-0055 734.78 µM -0.140407114457386 0.442203727513051 no 1898 0.444169168506711 2735 5179370
SGTC_1930 st074634 34.3 µM -0.141297697981683 0.441878387491844 no 1899 0.443817384057654 2653 684253 YOR116C RPO31
SGTC_91 0417-1751 58.384 µM -0.143803903387675 0.440963054006073 no 1900 0.442827660229461 2630 6795624
SGTC_386 1509-0011 3.07 µM -0.144178017888926 0.440826444275681 no 1901 0.442679949376537 2660 3107280
SGTC_2481 5478948 45.16 µM -0.145096048775346 0.440491250703269 no 1902 0.442317518948905 2784 77792
SGTC_800 3448-7362 155 µM -0.145312360443014 0.440412276682051 no 1903 0.442232128042911 2707 15991913
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.145844315951459 0.440218073179945 no 1904 0.442022145418986 2640 688667
SGTC_1180 1193-0155 285 µM -0.14586227631218 0.440211516557198 no 1905 0.442015056080582 2783 2921347
SGTC_2775 cyproheptadine 69.59 µM -0.146273837061647 0.440061276377307 no 1906 0.441852609346164 2675 2913 A selective serotonin reuptake inhibitor.
SGTC_1143 3454-2408 5.08 µM -0.147918720049097 0.439460898514751 no 1907 0.441203457130916 2640 X1143
SGTC_779 1360-0071 233 µM -0.148040501122352 0.439416454269122 no 1908 0.441155402551561 2867 7566
SGTC_3190 9110366 49.47 µM -0.14826206305576 0.439335596758386 no 1909 0.441067976857393 2715 17123768
SGTC_3152 9099253 49.47 µM -0.148672324747483 0.439185881247457 no 1910 0.440906100076396 2765 25236131
SGTC_2376 9072922 81.32 µM -0.149193265136956 0.438995788645383 no 1911 0.440700567080167 2789 17087968
SGTC_810 3825-7150 143 µM -0.15057517418593 0.438491594452691 no 1912 0.440155423101747 2755 22330411 YGL099W LSG1
SGTC_1631 benzylvanillin 81.9 µM -0.152142737907315 0.437919784388365 no 1913 0.439537178284608 2806 75506
SGTC_2951 9072950 58.06 µM -0.152357752349384 0.437841362300919 no 1914 0.439452388370813 2668 16488155
SGTC_2697 mebhydrolin 72.4 µM -0.153126921242654 0.437560843804453 no 1915 0.439149093075011 2787 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_3322 9139058 2.11 µM -0.153783439568156 0.4373214341688 no 1916 0.438890245905001 2838 4908926 YPR165W RHO1
SGTC_369 0957-0393 4.5 µM -0.153967615674704 0.437254275600298 no 1917 0.43881763500654 2727 6997992
SGTC_2713 st079149 53.4 µM -0.154670194622022 0.436998101569781 no 1918 0.438540664213624 2752 3103253
SGTC_325 2810-4341 181 µM -0.154896600245961 0.436915555271931 no 1919 0.438451416955277 2806 774970
SGTC_833 3852-0053 558 µM -0.155823441455144 0.436577662522798 no 1920 0.438086096357059 2838 3123681
SGTC_1381 2324-0066 62.1 µM -0.158433558327396 0.435626357822547 no 1921 0.437057585993775 2799 10885928
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.159552050226022 0.435218816704253 no 1922 0.436616976669017 2795 7104
SGTC_207 4185-0010 4.486 µM -0.16079699342325 0.434765281880476 no 1923 0.436126646661917 2717 3761753
SGTC_2057 5236571 38.335 µM -0.161473442857787 0.434518886203669 no 1924 0.435860263197007 2794 54684039 YBR257W POP4
SGTC_216 k038-0035 28.382 µM -0.162326904552161 0.434208050377966 no 1925 0.435524214438277 2674 4444231 YPR107C YTH1
SGTC_1545 lovastatin 49.4 µM -0.164488295525381 0.433421041288989 no 1926 0.434673380035786 2743 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1084 voriconazole 435 nM -0.164786800302529 0.433312369931201 no 1927 0.434555896918729 2713 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1113 artemisinin 1.17947 µM -0.165772430404382 0.432953584854935 no 1928 0.434168021622782 2733 2240 An anti-malaria and mitochondrial poison.
SGTC_2046 4110841 106 µM -0.166042411050179 0.432855317223236 no 1929 0.434061787102905 2775 44119630 YMR134W ERG29
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.167291486872058 0.432400732389376 no 1930 0.433570351120337 2786 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2290 7904846 200 µM -0.16795541983564 0.432159139035768 no 1931 0.433309175299441 2785 2962154
SGTC_92 0063-0024 660.874 µM -0.168494409620511 0.431963028925035 no 1932 0.433097170637908 2646 3594437
SGTC_835 0312-0010 67.2 µM -0.168906132789249 0.431813235751884 no 1933 0.432935237621276 2700 1626196
SGTC_2800 7887935 81.82 µM -0.169513990895283 0.431592102668957 no 1934 0.432696184233734 2864 2961002
SGTC_3294 9122953 26.2835 µM -0.169728960816571 0.431513903753449 no 1935 0.432611648539702 2701 16459826
SGTC_1128 3448-9350 235 µM -0.170477339196355 0.431241689517682 no 1936 0.432317377099109 2817 619386
SGTC_244 nsc-207895 1.295 µM -0.170700933252876 0.431160366019283 no 1937 0.43222946448513 2674 42640
SGTC_2185 6113692 200 µM -0.170865729739286 0.431100429680413 no 1938 0.432164672021832 2823 874150
SGTC_1117 retinoic acid 1.10837 µM -0.170969836329295 0.4310625670218 no 1939 0.43212374173492 2861 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2336 9001819 198.65 µM -0.171321385734281 0.430934716253764 no 1940 0.431985532835041 2915 2989602
SGTC_15 0266-0086 27.098 µM -0.171541698701405 0.43085459697302 no 1941 0.431898922756318 2751 1712902 YIL048W NEO1
SGTC_3209 9113616 49.47 µM -0.17167084931444 0.430807631227322 no 1942 0.431848152210702 2821 16649353
SGTC_2780 5215298 71.43 µM -0.172181990593502 0.430621763811927 no 1943 0.431647227927432 2804 2834131
SGTC_2403 6032726 181.2 µM -0.172294860530688 0.430580722741132 no 1944 0.431602862318925 2789 2881040
SGTC_89 0302-0250 142.109 µM -0.173159181042767 0.430266468731103 no 1945 0.431263153855995 2675 4203518 YLR208W SEC13
SGTC_611 3453-1652 23.7 µM -0.173441305782823 0.430163901946322 no 1946 0.431152279870549 2777 1560575
SGTC_3 0833-0587 95.581 µM -0.174988107982728 0.429601644086557 no 1947 0.430544488933046 2741 5382644
SGTC_1212 0520-0165 585 µM -0.175853044956067 0.429287304309229 no 1948 0.430204697536977 3126 5403258
SGTC_2651 TUB2.036 5 µM -0.177540310274396 0.428674239009263 no 1949 0.429542002548759 2802 15992207 YFL037W TUB2
SGTC_530 4358-1714 28 µM -0.177621771192574 0.428644644650236 no 1950 0.429510012741555 2830 1564641
SGTC_3043 9092303 49.47 µM -0.177737228074963 0.42860270040858 no 1951 0.429464673468508 2747 25236084
SGTC_3150 9097574 49.47 µM -0.178847417220066 0.428199421877629 no 1952 0.429028755961342 2826 17217476
SGTC_234 nsc-17383 10.7 µM -0.179240596586396 0.42805661660667 no 1953 0.428874394192936 2789 408974
SGTC_236 1509-0011 5.31 µM -0.181973273067492 0.427064352270109 no 1954 0.427801850341319 2813 3107280
SGTC_2960 9079389 5.97 µM -0.18264625931396 0.426820054248341 no 1955 0.427537792568297 2859 16457355
SGTC_563 tetrahydrosecaminediol 614 µM -0.183708917443599 0.426434360195277 no 1956 0.427120906434322 2868 334274 A psychoactive constituent of the cannabis plant.
SGTC_362 0310-0100 9.03 µM -0.183830303326097 0.426390307397899 no 1957 0.427073291311645 2867 790235
SGTC_3182 9108849 49.47 µM -0.185973684486444 0.42561259328906 no 1958 0.426232699021339 2813 17133045
SGTC_669 0108-0021 26.2 µM -0.186024449256198 0.425594177065887 no 1959 0.426212794115111 2694 17201
SGTC_2653 dihydrofissinolide 100 µM -0.186621799584035 0.425377485105795 no 1960 0.425978586713567 2789 6857746
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.187105992184347 0.425201858240024 no 1961 0.42578876502284 2740 5106787 A p450 inhibitor.
SGTC_2693 st077581 40.7 µM -0.188763155773991 0.42460088260132 no 1962 0.425139225040204 2794 25238761
SGTC_205 1486-1330 71.903 µM -0.189505285584515 0.424331803593664 no 1963 0.424848406429294 2727 4118834
SGTC_1008 4106-0037 6 µM -0.190285054717614 0.424049115437555 no 1964 0.42454288215067 2714 2905394
SGTC_1778 st046819 58.9 µM -0.19129150008955 0.423684308577299 no 1965 0.424148610038453 2762 671715
SGTC_2254 7938975 95.19 µM -0.19340307959525 0.422919135983025 no 1966 0.423321651899942 2952 2969277
SGTC_3065 9113888 49.47 µM -0.194763326733217 0.422426377294012 no 1967 0.422789116737028 2938 16648368
SGTC_3167 9103034 49.47 µM -0.19502114498058 0.422332994557207 no 1968 0.422688197068284 2724 5127859
SGTC_1921 5740136 50 µM -0.195093976013524 0.422306615674307 no 1969 0.422659689207058 2890 1774243
SGTC_2688 kanamycin b 96.69 µM -0.195234381112988 0.422255762927995 no 1970 0.4226047323341 2873 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_2938 9059746 27.26 µM -0.197117010121859 0.421574026778743 no 1971 0.42186798620988 2880 6471769
SGTC_613 3914-0030 117 µM -0.197772083953174 0.421336866961228 no 1972 0.421611694260005 2706 1145395
SGTC_2206 7254556 146.969 µM -0.198190136970241 0.42118553194384 no 1973 0.421448151994865 2800 4398905
SGTC_2863 9028737 58.44 µM -0.198300879819173 0.421145445028608 no 1974 0.421404831681195 2862 6460917
SGTC_2107 5363541 170.161 µM -0.198788359761616 0.420968995800328 no 1975 0.421214150920416 2779 244052
SGTC_3244 9134489 49.47 µM -0.198804950538373 0.420962990848259 no 1976 0.4212076616615 2830 16584271
SGTC_3100 9120536 49.47 µM -0.199730401964396 0.420628057303228 no 1977 0.420845717744024 2702 16421196
SGTC_255 tunicamycin 200.472 nM -0.200614097948292 0.420308289242361 no 1978 0.420500166806177 2851 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1732 st034308 51.822 µM -0.201142128368074 0.420117244926591 no 1979 0.420293720710025 2701 830119
SGTC_1418 3966-3099 2.4 µM -0.201847074696146 0.419862220802449 no 1980 0.42001813930135 2840 740335
SGTC_2928 9011484 9.79 µM -0.202430477096639 0.41965119232336 no 1981 0.419790102144819 2889 2994751
SGTC_3219 9131112 49.47 µM -0.20292029599336 0.419474032735208 no 1982 0.419598665192192 2806 17612988 YMR079W SEC14
SGTC_396 dithiazanine 1.25 µM -0.203086187609305 0.41941403611376 no 1983 0.419533833733012 2786 10578 An antihelmenthic.
SGTC_1620 st003704 16.5 µM -0.203644761690441 0.419212035119514 no 1984 0.419315555630593 2784 2834414
SGTC_1970 st070122 35.8 µM -0.205283374650348 0.418619575263497 no 1985 0.418675366282611 2937 102928
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.205882341041295 0.418403057882869 no 1986 0.418441409879924 2967 94937 An inhibitor of serotonin biosynthesis.
SGTC_1474 0330-0125 5.35 µM -0.205920393389171 0.418389303363434 no 1987 0.418426547598317 2805 X1474
SGTC_2894 9048625 32.47 µM -0.206573496943743 0.418153246099589 no 1988 0.418171480090134 2909 4092861
SGTC_1281 0884-0031 11.8 µM -0.206985703161588 0.41800427375939 no 1989 0.418010511973605 2775 1548255
SGTC_1229 0139-0193 12.2 µM -0.207124441358994 0.417954136078844 no 1990 0.417956337260601 2884 3090752
SGTC_2021 4019055 173 µM -0.211140859925126 0.416503250359067 no 1991 0.416388678622628 2881 44827708 YER133W GLC7
SGTC_3108 9121785 49.47 µM -0.213999453171226 0.415471307201116 no 1992 0.415273741804666 2707 17140271
SGTC_1658 st012944 20 µM -0.215247004730433 0.415021127251675 no 1993 0.414787372609409 2840 24207260
SGTC_592 k241-0073 46.5 µM -0.215578595322199 0.414901491270992 no 1994 0.414658120972777 2899 4230158
SGTC_2919 7978188 46.38 µM -0.216146184301926 0.414696726748688 no 1995 0.41443690030549 2935 2980291
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.2173584049902 0.414259481291361 no 1996 0.413964522138561 2744 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_3326 9140064 16.379 µM -0.219216575715188 0.41358944943135 no 1997 0.413240671973129 2778 1868434
SGTC_913 3487-1245 167 µM -0.219631397642844 0.413439904389479 no 1998 0.413079118311897 2761 4016153
SGTC_568 1193-0097 7.48 µM -0.220210329717747 0.413231217946191 no 1999 0.412853676064609 2876 3646150
SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.221826820288566 0.412648654901402 no 2000 0.412224349991213 3148 5282309
SGTC_2061 5245884 80.95 µM -0.221832733414723 0.412646524236805 no 2001 0.412222048328239 2792 573863
SGTC_2407 paclitaxel 400 µM -0.222094887381354 0.41255206542415 no 2002 0.412120008879836 3040 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3078 9116413 49.47 µM -0.223251027304679 0.412135547800109 no 2003 0.411670069944752 2739 17177322
SGTC_1761 st044296 37 µM -0.223321598261928 0.412110126700559 no 2004 0.411642609358009 2774 1826700
SGTC_1171 0368-0077 21.4 µM -0.223584976542506 0.412015255724204 no 2005 0.411540127364896 2803 3239779
SGTC_299 1273-0059 1.44 µM -0.223727812090117 0.411963807360542 no 2006 0.411484551760984 2900 2848077
SGTC_2690 usnic acid 100 µM -0.226227838898078 0.41106356100268 no 2007 0.410512109752287 3024 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_3130 9127414 49.47 µM -0.227745108864307 0.410517428137761 no 2008 0.409922200998543 2774 1494646
SGTC_1709 st033179 39.1045 µM -0.228582388909594 0.41021612805661 no 2009 0.409596756906172 2813 573381
SGTC_1854 st056233 32.9 µM -0.228882708305071 0.410108069283519 no 2010 0.4094800403109 2799 5393174
SGTC_2692 st077426 47.7 µM -0.230199924312319 0.409634198784257 no 2011 0.408968210334128 2962 25238571
SGTC_2967 9089538 49.85 µM -0.230793041998597 0.409420866829218 no 2012 0.408737793503212 3051 728216
SGTC_390 dec-rvkr-cmk 16.7 µM -0.231231026254999 0.409263350316394 no 2013 0.40856766379345 2874 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.232411500700105 0.408838877895237 no 2014 0.408109208595959 2860 676296 Flavone; oxidizing agent.
SGTC_3293 9120939 62.045 µM -0.232923728339227 0.408654725426734 no 2015 0.407910316294222 2968 934087
SGTC_3228 9131799 49.47 µM -0.235158416735117 0.407851562421357 no 2016 0.407042889834612 2878 17015818
SGTC_1446 4239-0190 62 µM -0.23692558073378 0.407216704935948 no 2017 0.406357262174213 2840 1340085
SGTC_2948 9070189 9.45 µM -0.237581492586368 0.406981129101034 no 2018 0.406102853166527 2986 6473636 YDL196W YDL196W
SGTC_824 1304-0008 100 µM -0.238546849281031 0.406634474977175 no 2019 0.405728491699425 2837 768245
SGTC_1982 st072467 71.9 µM -0.239386820244078 0.406332905664843 no 2020 0.405402824438389 2784 3163533
SGTC_1070 indatraline 8.81 µM -0.240052569752769 0.406093925404054 no 2021 0.405144751521132 2854 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2936 9038235 15.59 µM -0.241447062953011 0.405593465708098 no 2022 0.404604320242808 2817 4749415
SGTC_1335 1486-0900 202 µM -0.245617251542505 0.404097780153098 no 2023 0.402989266732495 2815 X1335
SGTC_2746 daunorubicin 9.88 µM -0.245722910869851 0.404059902339023 no 2024 0.402948367774024 2825 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3315 9136395 68.55 µM -0.246366594703 0.403829167554605 no 2025 0.402699231482154 2925 16876844
SGTC_1284 0929-0043 16 µM -0.247880330688487 0.403286686045619 no 2026 0.402113499444759 2903 1239883
SGTC_102 gallobenzophenone 83.616 µM -0.24791015110737 0.403276001089799 no 2027 0.402101962796218 3026 70837
SGTC_514 4466-0038 2.65 nM -0.248890144686421 0.402924899765237 no 2028 0.401722879434687 2883 5722064
SGTC_3052 9092717 49.47 µM -0.249772590530302 0.402608813724076 no 2029 0.401381608807328 3022 25237534
SGTC_1939 st074455 53.6 µM -0.250565975951435 0.402324682849098 no 2030 0.401074844955347 3079 1644229
SGTC_2870 9038528 12.99 µM -0.251733978573962 0.401906486253077 no 2031 0.400623345725677 2974 6463316
SGTC_379 3970-0972 5.9 µM -0.252957365436538 0.401468580052749 no 2032 0.400150579680235 2895 2898042 YBL034C STU1
SGTC_1504 k297-0033 30 µM -0.253924807171147 0.401122375907733 no 2033 0.399776824704114 2816 4388117
SGTC_2351 9026858 72.31 µM -0.253977312502833 0.40110358881524 no 2034 0.39975654276854 2829 1409300
SGTC_2296 7971656 126.45 µM -0.253987927804145 0.401099790549766 no 2035 0.399752442287222 2926 666570
SGTC_1756 st041558 35.5 µM -0.255197525283311 0.40066704526419 no 2036 0.399285271172621 3045 3955792
SGTC_2826 7992541 19.48 µM -0.256238229986118 0.400294820536555 no 2037 0.398883445248738 2798 2985066
SGTC_813 k007-0158 173 µM -0.257010109663491 0.400018803854 no 2038 0.398585484387161 2933 6523916
SGTC_1025 k007-0731 70 µM -0.257710820585117 0.399768279669645 no 2039 0.398315047253011 2864 6256118
SGTC_2043 5101342 149 µM -0.257744897564081 0.399756097226688 no 2040 0.398301896596335 2891 678451
SGTC_2462 5162487 171.77 µM -0.258643079228884 0.399435034527135 no 2041 0.397955320740518 2813 2259986
SGTC_2080 5212524 12.4 µM -0.259061202042776 0.3992855961422 no 2042 0.397794009697216 2911 260183
SGTC_3266 9136860 49.47 µM -0.259481927027828 0.399135242628007 no 2043 0.397631712376543 2908 4871271 YPR165W RHO1
SGTC_1390 3413-2614 145 µM -0.259648414828935 0.399075749398531 no 2044 0.397567493546737 2929 3421432
SGTC_8 0354-0001 70 µM -0.261549427051481 0.398396602755852 no 2045 0.396834419145101 2880 4993152
SGTC_3163 9099914 49.47 µM -0.262541026600574 0.398042470536522 no 2046 0.396452179817826 2959 16268368
SGTC_135 0933-0004 26.348 µM -0.263745975934458 0.397612257264399 no 2047 0.395987832891995 2989 21230617 YGL099W LSG1
SGTC_2941 9056145 11.23 µM -0.264047778384428 0.397504521654572 no 2048 0.395871551465132 2857 2119517
SGTC_3153 9100258 49.47 µM -0.265028346906911 0.397154538250373 no 2049 0.395493812357952 2900 25236848
SGTC_2977 9011197 71.43 µM -0.265481337951951 0.396992885144273 no 2050 0.395319342193392 3087 2704722
SGTC_972 1319-0219 195 µM -0.265950326634623 0.396825541811735 no 2051 0.39513873262081 2979 23903702
SGTC_2434 5670830 169.91 µM -0.268819202841894 0.39580229144455 no 2052 0.394034407685679 2973 1549830
SGTC_2489 cantharidin 73.42 µM -0.269095826473281 0.395703665120434 no 2053 0.393927971006959 2852 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_998 3996-0085 177 µM -0.269394788150792 0.395597081984038 no 2054 0.393812948210143 2948 715391
SGTC_2034 5197015 53.07 µM -0.270029239591036 0.395370918920752 no 2055 0.393568879467456 3038 780676
SGTC_208 k072-0098 12.366 µM -0.270855687057024 0.39507636783909 no 2056 0.393251014001367 2869 5948901
SGTC_3179 9107801 49.47 µM -0.270881471333946 0.395067179123891 no 2057 0.393241098082246 2877 4818259
SGTC_3261 9137475 49.47 µM -0.272332828258976 0.394550054841325 no 2058 0.392683058234382 2914 17027690
SGTC_1836 st055642 81 µM -0.272566065034482 0.394466968946524 no 2059 0.392593400339848 2898 8571
SGTC_3232 9132874 49.47 µM -0.273232133436588 0.394229721962632 no 2060 0.392337390248857 2890 3784940
SGTC_3279 9140807 49.47 µM -0.27346130118877 0.39414810374157 no 2061 0.39224931808445 2856 45595718
SGTC_36 0335-0881 14.2 µM -0.273548139613498 0.394117177402994 no 2062 0.392215946383785 2878 23828853
SGTC_1049 3226-0134 66 µM -0.274125701459277 0.393911503504175 no 2063 0.391994011581944 2903 5702385
SGTC_1413 3910-0535 34.4 µM -0.27417511763375 0.393893907424689 no 2064 0.391975024477557 3002 2876951
SGTC_1427 4048-4900 550 nM -0.275436988682039 0.393444654682911 no 2065 0.391490264886512 3014 24132586
SGTC_1667 st014849 34.6 µM -0.276157601128551 0.393188165016441 no 2066 0.391213510383236 2853 5348460
SGTC_2099 5377090 177.372 µM -0.27803576045835 0.392519884470291 no 2067 0.3904924538511 2985 2243829
SGTC_2492 derrusnin 100 µM -0.278405635660809 0.392388313952719 no 2068 0.390350496915495 2831 1715307 Part of coumarin class of compounds.
SGTC_310 1273-0058 1.06 µM -0.280081587261835 0.391792305533444 no 2069 0.389707455414721 3024 2734232
SGTC_1950 st077106 7.18 µM -0.282159106569877 0.391053842560464 no 2070 0.388910756529599 2991 13831864
SGTC_650 1328-0195 38 µM -0.283722585145023 0.390498356288671 no 2071 0.388311492619454 2988 2780821
SGTC_2231 micatex 6.853 µM -0.283760695154111 0.390484819018022 no 2072 0.388296888790362 2934 20737 An antifungal of unknown mechanism.
SGTC_315 k915-0449 187 µM -0.284444427286093 0.390241969254558 no 2073 0.38803490816887 2945 20970215 YNL149C PGA2
SGTC_894 0960-0238 55.9 µM -0.284966012671002 0.390056739984947 no 2074 0.387835090375985 2948 6741907 YDL195W SEC31
SGTC_3349 9149703 23.001 µM -0.287294806026991 0.389230026687287 no 2075 0.386943299649759 2872 4910494
SGTC_3160 9100216 49.47 µM -0.287902429272868 0.389014404900293 no 2076 0.38671071366147 2882 17191039
SGTC_2158 5657123 3.6195 µM -0.288846202224381 0.388679564487583 no 2077 0.386349537009411 2884 2858827
SGTC_607 4491-0986 66.8 µM -0.290010341196514 0.388266654527388 no 2078 0.38590416314871 3059 698981 YDR232W HEM1
SGTC_2641 levomentholum 100 µM -0.290489548271684 0.388096720605536 no 2079 0.385720872753522 2979 16666
SGTC_2306 7482397 179.52 µM -0.291505505952746 0.387736517869201 no 2080 0.385332366750372 3082 891448
SGTC_2602 kawain 100 µM -0.291758646203461 0.387646783273742 no 2081 0.385235582864105 2911 5369129
SGTC_2111 5486399 200 µM -0.295223614420389 0.386419106793696 no 2082 0.383911531901927 2940 689674
SGTC_1408 3909-7976 48.8 µM -0.295421332999224 0.386349087067496 no 2083 0.383836019380878 2965 24152374
SGTC_1736 st036774 51 µM -0.295724889148772 0.386241593404599 no 2084 0.383720094044561 3172 1272247
SGTC_1618 st003135 44.5 µM -0.2958657748699 0.386191706680529 no 2085 0.383666294602305 2910 1270615
SGTC_3159 9100096 49.47 µM -0.299616266139998 0.384864376092579 no 2086 0.382234937650362 2833 25236875
SGTC_1524 corynanthine 62.1 µM -0.300109785773984 0.384689815363216 no 2087 0.382046707544141 3101 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_665 3914-0008 307 µM -0.300672776674834 0.384490710790725 no 2088 0.381832014896398 2935 1069549
SGTC_385 1494-0393 12.4 µM -0.300935458821784 0.384397822345274 no 2089 0.381731855323805 2975 3090647
SGTC_1322 1348-1070 12 µM -0.302717483217123 0.383767846634831 no 2090 0.381052586449411 3038 6758089
SGTC_1458 k015-0034 6.33 µM -0.303258021966721 0.383576817682327 no 2091 0.380846617177276 2988 3598957
SGTC_1724 st037281 8.293 µM -0.303755353571493 0.383401083330595 no 2092 0.380657141565382 2917 574124 YDL195W SEC31
SGTC_2411 st077133 39.94 µM -0.304641021258954 0.383088188096943 no 2093 0.380319786838701 3230 1403142 YNL221C POP1
SGTC_1510 1123-0200 71.5 µM -0.304805204914633 0.383030192453388 no 2094 0.380257258552666 3131 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1150 3909-7983 10.9 µM -0.309013567227705 0.381544544016857 no 2095 0.378655603206965 2984 23965914
SGTC_2002 4023503 131 µM -0.310192781318254 0.381128566157504 no 2096 0.378207179830788 3082 4736863 YCR052W RSC6
SGTC_326 k292-0812 17.5 µM -0.310278577974395 0.38109830600629 no 2097 0.378174560065199 3032 3579357
SGTC_1699 st031318 29.054 µM -0.310636635938171 0.380972028187792 no 2098 0.378038436317388 3063 5340658
SGTC_576 1073-0113 22.7 µM -0.311656579839902 0.380612389774525 no 2099 0.377650764857403 3019 5439563
SGTC_1738 st035555 74 µM -0.31442307142923 0.379637428175526 no 2100 0.376599867782883 3074 5331140
SGTC_2544 sphondin 68.51 µM -0.314425762046835 0.379636480324542 no 2101 0.376598846151372 3160 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_3264 9137442 49.47 µM -0.315047538085947 0.379417460418739 no 2102 0.376362780055045 3195 17015726
SGTC_1301 naphtanilide LB 4.81 µM -0.31523529133303 0.379351332152457 no 2103 0.376291505955937 3079 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_200 k038-0079 37.545 µM -0.31690039909027 0.378765021918988 no 2104 0.375659589597712 2966 3436683
SGTC_1866 st057638 64 µM -0.318171596323621 0.378317601334421 no 2105 0.375177388476886 2983 688802
SGTC_1392 3455-1037 33.9 µM -0.324074960162271 0.376241953208236 no 2106 0.372940641841651 3129 981132
SGTC_137 0438-0332 85.389 µM -0.325227419367768 0.375837158723299 no 2107 0.372504479028853 3061 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_185 k048-0037 25.491 µM -0.325359631878615 0.375790728586554 no 2108 0.372454451967507 3114 6827589
SGTC_648 0375-0473 33.3 µM -0.325410969163482 0.37577270054171 no 2109 0.372435027354794 2975 1713139
SGTC_486 niguldipine 82 µM -0.32620825791713 0.375492752561376 no 2110 0.372133396961419 2984 1236 A calcium channel blocker.
SGTC_914 3820-6779 408 µM -0.326574988675457 0.375364006238964 no 2111 0.371994681656574 2934 2893481
SGTC_2327 6189656 200 µM -0.326724038299882 0.37531168410362 no 2112 0.371938308628754 3091 5349088
SGTC_1311 1190-0148 100 µM -0.327670741148465 0.374979408681352 no 2113 0.37158031412644 3114 1961333
SGTC_2195 6536160 144.242 µM -0.32974245085309 0.374252600326772 no 2114 0.370797287435249 2965 3834386
SGTC_3116 9124943 49.47 µM -0.330088606904253 0.374131203481043 no 2115 0.370666505800433 3004 41905195 YPL160W CDC60
SGTC_2647 atorvastatin 60.16 µM -0.331130989287352 0.373765715648434 no 2116 0.370272772360276 3051 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_1397 3532-0190 20.1 µM -0.331181714873309 0.373747932760764 no 2117 0.370253615523969 2919 5322280
SGTC_2381 9035592 200 µM -0.333166357443009 0.373052387189094 no 2118 0.369504355835575 3049 4749657
SGTC_84 0443-0269 128.823 µM -0.33343074919935 0.372959758591477 no 2119 0.369404577664755 3104 6150058
SGTC_2594 a-mangostin 100 µM -0.333580341812371 0.372907352668709 no 2120 0.369348127163078 3141 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1574 spiramycin 23.7 µM -0.334107936973217 0.372722542060501 no 2121 0.369149055524943 2943 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2586 curcumin 80 µM -0.334912678917576 0.372440706504899 no 2122 0.368845478754232 3109 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2182 6325192 200 µM -0.335974969000732 0.372068777412834 no 2123 0.368444871128817 3047 736248
SGTC_1234 0326-0494 15.5 µM -0.337011973481882 0.37170581641192 no 2124 0.368053937019095 3137 1547813
SGTC_2781 5567276 71.43 µM -0.337071497454876 0.371684985936964 no 2125 0.368031501574869 3146 2853274
SGTC_2079 5212404 121 µM -0.337698862295721 0.371465461829527 no 2126 0.367795066102359 3142 758462
SGTC_856 0433-0016 11.3 µM -0.33830740421362 0.371252564073731 no 2127 0.367565772293023 3090 3911780
SGTC_2387 9077560 195.08 µM -0.340569131146103 0.370461646985902 no 2128 0.36671398568166 3016 5303272
SGTC_2841 9004761 38.96 µM -0.341559984210369 0.370115321720725 no 2129 0.366341027922293 3028 2991039
SGTC_1493 4348-0038 111 µM -0.34203145320377 0.369950569731774 no 2130 0.366163610967298 3075 800424
SGTC_1686 st019653 115.5 µM -0.342055379176619 0.369942209581241 no 2131 0.366154608225128 3131 97252
SGTC_139 0099-0334 718.624 µM -0.342714742648009 0.369711840728842 no 2132 0.365906535334154 2977 97690
SGTC_430 0958-0115 16.4 µM -0.34437415827397 0.369132280049649 no 2133 0.36528246020669 3029 6833180
SGTC_1112 tnp00069 1.16933 µM -0.34455082350056 0.369070596170545 no 2134 0.365216040697376 3108 145826
SGTC_357 1325-0123 420 µM -0.348936631212633 0.367540345785706 no 2135 0.363568441884284 3135 1098503
SGTC_3310 9130229 44.1445 µM -0.348966760208366 0.367529840728225 no 2136 0.363557132126823 3156 7761258
SGTC_450 aminopyrene 156 nM -0.34937849894657 0.367386289984805 no 2137 0.363402586446895 3138 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.350901394179915 0.366855501005833 no 2138 0.362831162755023 3087 4213774
SGTC_3263 9137018 49.47 µM -0.351702569438487 0.366576361947429 no 2139 0.362530666700257 3077 43844957
SGTC_2964 9083345 53.42 µM -0.352401960304375 0.366332743465863 no 2140 0.362268416026882 3072 17741579
SGTC_1231 0242-0792 125 µM -0.352778479094615 0.366201613153997 no 2141 0.362127259487381 3007 3707635
SGTC_528 3492-0019 172 µM -0.353551091658778 0.365932584081615 no 2142 0.361837666491567 3106 2869262
SGTC_3139 9095020 49.47 µM -0.35447206377073 0.365611981295816 no 2143 0.361492568264405 2918 25236292
SGTC_1569 carminic acid 40.6 µM -0.357909695494067 0.364416126029985 no 2144 0.360205447385398 3201 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_673 1082-0474 110 µM -0.358473078116095 0.364220266523294 no 2145 0.359994655793208 3072 3098046
SGTC_86 0417-1630 471.922 µM -0.359538070262914 0.363850119769437 no 2146 0.359596301565542 3123 3634867
SGTC_1324 1418-0026 34.4 µM -0.360675636953079 0.363454889429693 no 2147 0.359170969699841 3141 1372513
SGTC_3148 9097893 49.47 µM -0.360913011802907 0.363372435437891 no 2148 0.359082238131245 3026 17174100
SGTC_3225 9130819 49.47 µM -0.36312353396833 0.362604897851305 no 2149 0.358256302604673 3173 4547121
SGTC_2083 5306046 65.942 µM -0.36460527182542 0.362090717479965 no 2150 0.357703039513349 3065 539837
SGTC_1116 jasmonic acid 1.58368 µM -0.364738994893299 0.362044326236127 no 2151 0.357653123613434 3179 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_836 0330-0104 1.35 µM -0.364888875433745 0.36199233204619 no 2152 0.357597179375576 3063 46494820
SGTC_1933 st074711 15.9 µM -0.364893435621561 0.361990750137773 no 2153 0.357595477293078 3074 17250958
SGTC_2325 6158266 200 µM -0.365592698095396 0.361748207079362 no 2154 0.357334512274215 3108 3623240
SGTC_1980 st071811 45.7 µM -0.367306506414293 0.361153998171455 no 2155 0.356695200678571 3195 4974850
SGTC_3060 1327-0027 12.5 µM -0.369060898291475 0.36054606503322 no 2156 0.356041166700909 3110 16000455 YPR107C YTH1
SGTC_1471 k673-0312 37 µM -0.370451529113374 0.360064432860484 no 2157 0.355523042843664 3093 24099884
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.372427250930196 0.359380541799292 no 2158 0.354787383764471 3308 6728940
SGTC_335 4077-0256 27.6 µM -0.373341372426258 0.359064273184165 no 2159 0.354447194006927 3121 3121989
SGTC_798 1287-0182 476 µM -0.375621085590953 0.358275957010443 no 2160 0.353599306394703 3239 1649755
SGTC_1633 st005664 67.9 µM -0.376058738862906 0.358124687139246 no 2161 0.353436614105485 3013 2063822
SGTC_637 1181-0519 7.26 µM -0.376551899756182 0.357954258376052 no 2162 0.3532533196167 3087 6252091 YGR060W ERG25
SGTC_2165 5727197 32.143 µM -0.37692195822336 0.357826390491718 no 2163 0.353115801300409 3405 1361712
SGTC_1711 st032263 62.8 µM -0.377802767424744 0.357522104915532 no 2164 0.352788558863128 3104 3958979
SGTC_1181 1222-0449 220 µM -0.378532687577281 0.357270014280661 no 2165 0.352517457934805 3237 658318
SGTC_730 1436-0052 41.2 µM -0.379790948861175 0.356835598108773 no 2166 0.352050300798371 3092 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1137 ixabepilone 100 µM -0.380940154198776 0.356438995768259 no 2167 0.351623828072977 3038 154225 A novel microtubule stabilizer.
SGTC_2025 5147754 141 µM -0.381542687359159 0.356231117495093 no 2168 0.351400301199691 3126 315777 YLR208W SEC13
SGTC_1988 st071872 53.4 µM -0.381929351432409 0.356097738108604 no 2169 0.35125688418752 3202 16414116
SGTC_472 calcifediol 10 µM -0.382104955955405 0.35603716931647 no 2170 0.351191757959836 3122 5283731 A vitamin D metabolite.
SGTC_2600 tangeritin 87.95 µM -0.382598190383168 0.355867064356557 no 2171 0.351008856110027 3037 68077 A bioactive flavone.
SGTC_774 k060-0086 136 µM -0.38362900995324 0.355511651593168 no 2172 0.350626717698193 3274 5911235
SGTC_2003 4023581 200 µM -0.384067191732332 0.355360610417371 no 2173 0.350464323675211 3208 16641307
SGTC_552 k242-0005 476 µM -0.385393338062759 0.354903626525645 no 2174 0.349973008790436 3204 4088318
SGTC_2588 indole-3-carbinol 100 µM -0.38817887696978 0.353944422855867 no 2175 0.348941831857284 3210 3712 Induces cell cycle arrest.
SGTC_747 3448-8087 38.7 µM -0.391761194469039 0.352712209616204 no 2176 0.347617335027563 3122 5168703
SGTC_111 0083-0039 52.457 µM -0.392215513774735 0.352556046994068 no 2177 0.347449491142471 3036 759313
SGTC_608 k048-0125 159 µM -0.393159219946281 0.352231747453634 no 2178 0.347100943610833 3213 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_439 amiodarone 34.4 µM -0.396335536287737 0.351141013880982 no 2179 0.345928757462922 3106 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1467 k284-1082 293 µM -0.399449122242041 0.35007301047009 no 2180 0.344781152561784 3192 3334705
SGTC_2742 clothiapine 36.27 µM -0.399801181755188 0.349952323549502 no 2181 0.34465148012363 3163 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_1333 1482-0047 286 µM -0.401844223341542 0.349252263076221 no 2182 0.343899336833244 3236 3811116
SGTC_1758 st042942 75.2445 µM -0.403585136246405 0.348656133167082 no 2183 0.343258908824225 3190 669317
SGTC_736 0958-0254 92.6 µM -0.406500542822022 0.34765866578174 no 2184 0.342187429106436 3229 6812352
SGTC_3084 9116877 49.47 µM -0.406666436794696 0.347601938997587 no 2185 0.342126497302885 3184 27241325
SGTC_1719 st032227 49.2 µM -0.40712390903334 0.347445525867542 no 2186 0.341958491953418 3108 3125804
SGTC_2685 mycophenolic acid 18.85 µM -0.40751604585692 0.347311472069586 no 2187 0.341814505748174 3138 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_468 gf-109203x 121 µM -0.408040097922001 0.347132352250897 no 2188 0.34162211835356 3148 2396 A protein kinase C inhibitor.
SGTC_1149 3909-7961 23.3 µM -0.409036752193201 0.346791792306609 no 2189 0.341256345123763 3150 735261
SGTC_2994 9053520 71.4286 µM -0.411377792249419 0.345992338577384 no 2190 0.340397767708029 3231 4647384
SGTC_2650 prasterone 100 µM -0.412335181249136 0.345665592345864 no 2191 0.340046882776475 3196 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_988 1497-1057 103 µM -0.413208571612307 0.345367614157867 no 2192 0.339726904298649 3266 3533044
SGTC_903 1134-0042 114 µM -0.413524381239811 0.345259891663652 no 2193 0.339611231543407 3140 701009
SGTC_223 busulfan 5 mM -0.41386945263765 0.345142202326462 no 2194 0.339484858241664 3215 2478 A DNA alkylator.
SGTC_796 1234-0020 70.7 µM -0.414176403389961 0.34503752692281 no 2195 0.339372460787223 3133 46495034
SGTC_2519 cryptotanshinone 88.04 µM -0.414198552191738 0.345029974264948 no 2196 0.339364351019454 3273 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_1257 0669-0121 16 µM -0.415255092438087 0.344669769786955 no 2197 0.338977586051699 3190 4307855
SGTC_3341 9147222 25.867 µM -0.416955062337404 0.344090497515711 no 2198 0.338355638682874 3259 1939759
SGTC_252 miconazole 1.30953 nM -0.41701698042457 0.344069405547385 no 2199 0.338332993772199 3202 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1215 3852-0577 11.2 µM -0.417631817657607 0.343859991829871 no 2200 0.338108164978016 3282 2884876
SGTC_465 cgp-37157 41 µM -0.418070176638791 0.343710715891022 no 2201 0.337947904593013 3182 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_3001 9076041 71.4286 µM -0.419343318976769 0.343277306431459 no 2202 0.337482620977217 3130 16004211
SGTC_917 harmaline 728.087 nM -0.419847273167835 0.343105804722957 no 2203 0.337298514048154 3212 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_106 0092-0003 11.579 µM -0.423313465331585 0.341927094669215 no 2204 0.336033285617379 3185 1072148
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.424722477438017 0.341448386643311 no 2205 0.335519498052052 3174 688669
SGTC_1140 3229-1848 2.98 µM -0.425243047219228 0.341271588936997 no 2206 0.335329753210918 3254 2849525
SGTC_3101 9120531 49.47 µM -0.426937459866705 0.340696368054856 no 2207 0.334712440107658 3346 24824904
SGTC_2400 5203494 178.7 µM -0.429151253453006 0.339945385237669 no 2208 0.333906577559503 3208 6777674
SGTC_1786 berberine 21.6 µM -0.42993429070805 0.339679908143864 no 2209 0.333621720296235 3201 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1646 st011709 75.6 µM -0.430475999559468 0.339496296365021 no 2210 0.333424710805089 3254 5757843
SGTC_33 0986-0033 35.816 µM -0.431123286191399 0.339276949035782 no 2211 0.333189364869107 3235 2848082
SGTC_1886 st057356 49.9 µM -0.431853486621959 0.339029569902873 no 2212 0.332923951261201 3150 24207747
SGTC_1691 st019933 84.6 µM -0.43338889892304 0.33850962553289 no 2213 0.332366131967933 3247 6176082
SGTC_1976 st070609 63.5 µM -0.43455826290395 0.338113844278413 no 2214 0.331941547843116 3157 682556
SGTC_20 0481-0013 4.944 µM -0.434693584759034 0.338068054975389 no 2215 0.331892427774928 3226 182045
SGTC_2488 5268135 45.7 µM -0.434765344997649 0.338043774198393 no 2216 0.331866380916693 3280 1270356 YLR208W SEC13
SGTC_426 0988-0037 14.6 µM -0.435194431063118 0.337898602802469 no 2217 0.331710652242232 3329 5383008
SGTC_198 3454-2873 16.191 µM -0.436686152296058 0.337394100958527 no 2218 0.331169486635179 3187 710957
SGTC_1484 3473-2379 286 µM -0.438835481989814 0.336667709111987 no 2219 0.330390374216605 3310 671917
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.439290478285578 0.336514015647575 no 2220 0.330225536313218 3163 16623 A steroid.
SGTC_1746 st038117 42 µM -0.43968948189139 0.336379258460357 no 2221 0.330081010779754 3251 2898218
SGTC_919 tnp00227 403.569 nM -0.43979680383705 0.336343015748546 no 2222 0.330042141368218 3169 1269246 A methoxyflavone. YNL221C POP1
SGTC_685 1278-0033 54.9 µM -0.442361697743029 0.335477302046976 no 2223 0.329113745533539 3311 3590572
SGTC_1250 0485-0349 40.2 µM -0.443160706956662 0.335207795189032 no 2224 0.328824748858956 3173 6842794 YDL195W SEC31
SGTC_840 0245-0196 390 µM -0.444006489988408 0.334922603855919 no 2225 0.328518945859655 3325 3827528
SGTC_59 0330-0160 1.33 µM -0.444431156818497 0.334779445444637 no 2226 0.328365445760726 3279 4293482
SGTC_2729 fluphenazine 10.66 µM -0.445684010596934 0.334357238895764 no 2227 0.327912758035788 3165 3372 An atypical antipsychotic.
SGTC_497 capsazepine 133 µM -0.445723771237999 0.334343843150222 no 2228 0.327898395645669 3203 2733484 A calcium channel blocker.
SGTC_3307 9126885 69.2785 µM -0.445959768558016 0.334264337706963 no 2229 0.327813153628448 3172 24824909
SGTC_2717 st081029 62.2815 µM -0.446109918254302 0.334213757450722 no 2230 0.327758924364013 3286 5292846
SGTC_3305 9127027 53.8275 µM -0.446199163765125 0.334183695141222 no 2231 0.327726693463044 3178 41905295
SGTC_1650 st011916 45.8 µM -0.446305283382066 0.334147950181168 no 2232 0.327688370170855 3313 242528
SGTC_1887 st057648 70.8 µM -0.446607809992292 0.334046056434969 no 2233 0.327579127802027 3283 688672
SGTC_2384 9036245 200 µM -0.448397669925234 0.333443465610806 no 2234 0.326933111554183 3211 6462766
SGTC_87 0100-0052 35.5 µM -0.4493375714518 0.33312720155662 no 2235 0.326594079222084 3318 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1295 1013-0063 9.78 µM -0.453764580843568 0.331639171729971 no 2236 0.324999139562187 3321 6826038
SGTC_77 0828-0286 12.516 µM -0.453885370342687 0.331598608399748 no 2237 0.324955666900829 3302 745345
SGTC_2052 5265182 7.135 µM -0.46072344058795 0.329305491617091 no 2238 0.322498517666191 3323 1239884
SGTC_1747 st037496 66.6 µM -0.461264396529348 0.329124356755002 no 2239 0.322304462671426 3194 723305
SGTC_2749 bexarotene 57.39 µM -0.461266451220609 0.329123668834155 no 2240 0.322303725692388 3255 82146 An retinoic acid receptor inhibitor.
SGTC_512 prima-1 270 µM -0.46144154706087 0.329065048002446 no 2241 0.322240924680126 3350 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1404 3909-7820 48.3 µM -0.462719505919595 0.328637323913367 no 2242 0.321782717404185 3310 23741373
SGTC_3091 9116372 49.47 µM -0.4645141009076 0.32803706415151 no 2243 0.321139729615252 3356 17169793
SGTC_3235 9132602 49.47 µM -0.464725422233755 0.327966410148951 no 2244 0.321064050248916 3347 4912240
SGTC_340 k038-0059 454 µM -0.466916626179663 0.327234157675808 no 2245 0.320279764746271 3296 23733424
SGTC_1669 st015249 58.4 µM -0.467593794065164 0.327007997225959 no 2246 0.320037551877429 3333 722793
SGTC_1366 1683-0113 21.9 µM -0.467729170517331 0.326962791830463 no 2247 0.319989138930938 3221 708623
SGTC_2837 9008476 45.46 µM -0.468662089259835 0.326651337292088 no 2248 0.31965559453795 3356 2992805
SGTC_298 1391-0729 10 µM -0.471857376480159 0.325585508259127 no 2249 0.318514296769978 3228 3237558
SGTC_1770 st043884 66.3 µM -0.472493289656249 0.325373560940747 no 2250 0.318287365154303 3266 670149
SGTC_1498 4478-3555 97.6 µM -0.475992828849043 0.324208190454974 no 2251 0.317039743412777 3307 3437919
SGTC_1167 k781-0610 148 µM -0.479548396783591 0.323025923286158 no 2252 0.315774273547652 3249 4525169
SGTC_2200 6600604 21.907 µM -0.47990195258155 0.322908459348017 no 2253 0.315648556383056 3246 2904777
SGTC_428 3448-4153 16.5 µM -0.481005490908836 0.322541937917382 no 2254 0.315256298104786 3160 3834874
SGTC_2952 9073731 13.78 µM -0.481197617112501 0.322478144085643 no 2255 0.315188027138869 3258 16457353
SGTC_165 k038-0023 64.381 µM -0.481369985925254 0.322420914971264 no 2256 0.315126782221858 3244 46368543
SGTC_1518 st038567 90.8 µM -0.48176798674613 0.322288788614493 no 2257 0.314985386685538 3328 77966
SGTC_970 1315-0089 19.5 µM -0.482010563494874 0.322208270187354 no 2258 0.31489922108967 3321 6811083 YLR033W RSC58
SGTC_787 4152-0075 138 µM -0.482069719189718 0.322188635920532 no 2259 0.314878209945293 3260 9566539
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.486610347288862 0.3206830478672 no 2260 0.313267244707911 3312 1241132 A phosphatase inhibitor.
SGTC_3224 9130643 49.47 µM -0.486742328854882 0.320639329159109 no 2261 0.313220472143584 3419 17644395
SGTC_3354 9151612 71.43 µM -0.487266101027998 0.320465854896793 no 2262 0.313034883670715 3365 27261949
SGTC_1745 st081495 74 µM -0.48759242133166 0.320357796864476 no 2263 0.312919282365535 3330 13842402 YBL026W LSM2
SGTC_507 nimesulide 162 µM -0.488014311249695 0.320218114387937 no 2264 0.312769852101705 3417 4495 A COX2 inhibitor.
SGTC_551 k048-0028 34.9 µM -0.490268144306266 0.319472330376061 no 2265 0.311972082878319 3381 6836383
SGTC_794 k038-0031 316 µM -0.490551971015825 0.31937846496028 no 2266 0.311871681661567 3392 6624242
SGTC_380 3970-0968 6 µM -0.490834671327526 0.319284983564892 no 2267 0.311771692793163 3219 2891601
SGTC_64 000l-0018 272.079 µM -0.491167570360337 0.319174917529839 no 2268 0.311653966821214 3294 6811119
SGTC_646 4092-0839 27.3 µM -0.493528391770683 0.318394819525178 no 2269 0.31081964190329 3417 877796
SGTC_2738 aclarubicin 5.55 µM -0.493608936655059 0.318368218850752 no 2270 0.310791194096934 3267 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_3250 9135583 49.47 µM -0.494436435754925 0.318094984062083 no 2271 0.310498993583204 3376 7699353
SGTC_1683 st010134 710 nM -0.494729050352549 0.317998388315258 no 2272 0.310395696225605 3239 3818134
SGTC_2219 9098279 200 µM -0.49548648679277 0.317748406564953 no 2273 0.310128379224538 3348 902349
SGTC_1088 bifonazole 369 nM -0.496028083184003 0.317569710847981 no 2274 0.309937298711552 3331 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_46 0329-0187a 2.197 µM -0.496541300976967 0.317400417652995 no 2275 0.309756277808063 3331 46494817
SGTC_3342 9147791 14.508 µM -0.497352726554413 0.3171328337261 no 2276 0.309470167922644 3313 1838168
SGTC_2998 9066762 71.4286 µM -0.497918029759373 0.316946470090678 no 2277 0.309270909377135 3448 4945196
SGTC_2681 menadione 3.18 µM -0.497937771734399 0.316939962588119 no 2278 0.309263951722425 3383 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_962 1254-0300 21.5 µM -0.498891255161159 0.316625735447937 no 2279 0.308927997479765 3292 7340576
SGTC_1437 4092-1038 11.6 µM -0.500214443261506 0.316189888743192 no 2280 0.308462044736998 3282 3977136
SGTC_2476 5806916 10.51 µM -0.501306754758933 0.315830283101873 no 2281 0.308077626080317 3245 2870194
SGTC_3282 9108498 15.4605 µM -0.502773367706684 0.315347725768682 no 2282 0.307561810039303 3336 16459645
SGTC_2249 haloperidol 116.36 µM -0.503361875090814 0.315154178577449 no 2283 0.307354935521728 3351 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2856 9022925 19.48 µM -0.505173534612097 0.314558682077224 no 2284 0.306718478449325 3376 4944862
SGTC_2910 7948405 25.97 µM -0.505594338724786 0.314420431769845 no 2285 0.30657072833435 3388 2971328
SGTC_562 3772-2733 112 µM -0.505692413127198 0.31438821430176 no 2286 0.3065362975777 3391 2876874 YIL048W NEO1
SGTC_1372 2752-0194 270 µM -0.505734116347013 0.314374515210978 no 2287 0.306521657440892 3363 823334
SGTC_346 4513-0042 7.16 µM -0.508766270062527 0.313379169009092 no 2288 0.305458032353606 3314 2827372
SGTC_1091 telmisartan 47.6 µM -0.511053355490195 0.312629299447766 no 2289 0.304656848185114 3407 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_815 1582-0027 36.9 µM -0.51163088155443 0.312440067683006 no 2290 0.304454684104146 3379 3128206
SGTC_884 0851-0618 334 µM -0.511704358089658 0.312415995960397 no 2291 0.304428967787055 3388 9642473
SGTC_287 k060-0039 29.6 µM -0.512217599098139 0.312247874878566 no 2292 0.304249363688899 3403 5861974
SGTC_928 2764-0428 58.7 µM -0.512407047597855 0.312185827578847 no 2293 0.304183079809213 3371 662578
SGTC_2496 diffractaic acid 79.83 µM -0.514654417774633 0.311450186048167 no 2294 0.303397265586652 3489 94870 An apoptosis inducer which activates caspases.
SGTC_1144 3486-0183 12.5 µM -0.514884088862902 0.311375049116736 no 2295 0.303317010029507 3340 6744069
SGTC_3024 9090631 49.47 µM -0.515613918936206 0.311136337260053 no 2296 0.303062043465956 3390 25236383
SGTC_1873 rapamycin 2 nM -0.516630491447838 0.31080397043323 no 2297 0.30270706315175 3345 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_176 1486-1328 72.834 µM -0.516773412135037 0.310757255099941 no 2298 0.302657171142528 3361 22310231
SGTC_1382 3002-2117 298 µM -0.517186381707276 0.310622288208069 no 2299 0.302513028804492 3456 1497314
SGTC_2787 5284540 71.43 µM -0.517429848023333 0.310542730382803 no 2300 0.302428064075046 3313 736958
SGTC_872 0588-0139 234 µM -0.519013055644975 0.310025599724088 no 2301 0.301875818482049 3356 2047100
SGTC_3339 9145883 14.936 µM -0.519613912022441 0.309829437396501 no 2302 0.301666349820365 3384 2030670
SGTC_317 4495-0002 170 µM -0.520064726094355 0.309682295108887 no 2303 0.301509231367314 3363 15991618
SGTC_825 1988-2224 89.6 µM -0.520889736516443 0.309413096952533 no 2304 0.301221792790642 3301 1180859
SGTC_2267 7931562 200 µM -0.521960902318728 0.309063731681179 no 2305 0.300848776490311 3234 934880
SGTC_614 0462-0418 107 µM -0.522022148577855 0.309043761168302 no 2306 0.300827454761974 3300 5188303
SGTC_1562 morin hydrate 59.1 µM -0.522444567287534 0.30890603884957 no 2307 0.30068041623415 3437 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_1364 1653-0028 37.6 µM -0.523640469283051 0.308516281400098 no 2308 0.300264314129863 3375 5718652
SGTC_587 k089-0003 57 µM -0.524461885013358 0.308248698003197 no 2309 0.299978661646113 3388 9659696
SGTC_1464 k208-0027 110 µM -0.525846711854075 0.30779780915546 no 2310 0.299497358036307 3465 X1464
SGTC_41 0478-0632 82.643 µM -0.526063771313582 0.307727162564823 no 2311 0.299421949662278 3441 3750424
SGTC_2851 9015922 71.43 µM -0.526687550280129 0.307524180195238 no 2312 0.299205291272541 3430 2996893
SGTC_949 1165-0505 146 µM -0.530026456147045 0.306438678101111 no 2313 0.298046793966966 3323 6244267
SGTC_1838 st055369 84.5 µM -0.530466442682692 0.306295761636622 no 2314 0.297894284764528 3374 676036
SGTC_296 1222-0039 74.9 µM -0.531589127702197 0.305931224550051 no 2315 0.297505298276113 3360 5984176
SGTC_687 k029-0044 34.9 µM -0.532435537376365 0.30565652139649 no 2316 0.297212188742144 3430 5829338
SGTC_3212 9128307 49.47 µM -0.53277679191133 0.305545797797067 no 2317 0.29709405050551 3209 27243542
SGTC_1901 st060216 58.6 µM -0.534331595787583 0.305041550616506 no 2318 0.296556067996812 3371 688792
SGTC_1133 3473-0247 50 µM -0.534559818054813 0.304967565683403 no 2319 0.29647713768227 3313 711311
SGTC_1443 4112-3303 14 µM -0.534604241808715 0.304953165349107 no 2320 0.296461774915842 3385 704433
SGTC_442 cape 100 µM -0.535146609958164 0.304777376503583 no 2321 0.296274240831729 3413 5281787
SGTC_131 0141-0277 33.849 µM -0.5356015970591 0.304629943789016 no 2322 0.296116962379695 3434 1547771
SGTC_1803 st050068 52.4 µM -0.535882539953282 0.304538923702831 no 2323 0.296019866095418 3490 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2999 9069765 71.4286 µM -0.536667576504254 0.304284651149565 no 2324 0.295748628205632 3357 2097066
SGTC_1846 st056244 14.8 µM -0.537032024460145 0.30416663896491 no 2325 0.295622746657854 3370 5393182
SGTC_3275 9138069 49.47 µM -0.537814496468609 0.303913334994341 no 2326 0.295352561439409 3408 17617007
SGTC_3042 9091578 49.47 µM -0.537871221942494 0.303894975327024 no 2327 0.295332978722619 3407 25236497
SGTC_2056 5235370 200 µM -0.538592049023271 0.303661716793583 no 2328 0.295084187500161 3322 5511916
SGTC_3118 9124250 49.47 µM -0.540303642700277 0.30310816817721 no 2329 0.294493823331572 3332 1504786
SGTC_3117 9124945 49.47 µM -0.540679857804717 0.302986556521865 no 2330 0.294364132050837 3274 17592065
SGTC_3128 9127691 49.47 µM -0.541204031340586 0.302817153670098 no 2331 0.294183479573707 3409 41316314
SGTC_2117 5521686 200 µM -0.541661519095713 0.302669337057546 no 2332 0.29402585172683 3346 803312
SGTC_2475 5812728 15.03 µM -0.542537319242054 0.302386451813439 no 2333 0.293724202912109 3412 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_729 4092-0585 94.1 µM -0.544660214636661 0.301701244853424 no 2334 0.292993616356134 3336 2169061
SGTC_1241 0364-0022 50.8 µM -0.545877338891454 0.301308708802316 no 2335 0.29257512819907 3360 4563895
SGTC_3355 9151058 44.0485 µM -0.547616435092177 0.300748230458349 no 2336 0.291977650994567 3443 17015728
SGTC_1829 berberine 14.4 µM -0.547890339166663 0.300659999170146 no 2337 0.291883601373185 3472 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_726 3448-4391 34.2 µM -0.549695305514772 0.30007886721075 no 2338 0.291264188644165 3538 1356692
SGTC_2846 9008642 19.48 µM -0.550180539686223 0.299922726572449 no 2339 0.291097774886584 3440 2992898
SGTC_475 α-linolenic acid 10 µM -0.550462534429837 0.299832002047023 no 2340 0.291001083628251 3551 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1053 3366-3204 134 µM -0.552264403197316 0.299252590891176 no 2341 0.290383607663202 3388 3632071 YPR165W RHO1
SGTC_403 arphamenine a 50 µM -0.554238617006508 0.298618344124564 no 2342 0.28970777651493 3416 5487158 An arginine aminopeptidase inhibitor.
SGTC_2976 9009005 19.48 µM -0.555098995899671 0.298342125466025 no 2343 0.289413474774598 3486 2993148
SGTC_1186 1319-0216 26 µM -0.555577914029043 0.298188422537638 no 2344 0.289249716611653 3503 4565136
SGTC_2869 9037858 32.47 µM -0.555877356845567 0.298092338349175 no 2345 0.289147349208705 3429 27187042
SGTC_2155 5570423 76 µM -0.556816541209338 0.297791067624173 no 2346 0.288826390565311 3352 797402
SGTC_830 4076-0286 57.8 µM -0.558697256839964 0.297188191237801 no 2347 0.288184175895763 3475 6866659
SGTC_2864 9034755 47.6 µM -0.55933584956852 0.296983612881888 no 2348 0.287966266666748 3470 4930451
SGTC_257 daunorubicin 18.5 µM -0.560128707553684 0.296729704083941 no 2349 0.28769582526186 3459 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_959 1222-0044 107 µM -0.562426090257492 0.295994540649101 no 2350 0.28691287360279 3465 6083612
SGTC_1840 st055363 71 µM -0.566404587919731 0.294723401533353 no 2351 0.285559388320613 3409 676033
SGTC_2125 5246583 200 µM -0.567347875447648 0.294422388593713 no 2352 0.285238928067179 3532 835267
SGTC_2740 felodipine 17.08 µM -0.567572354235071 0.294350775970772 no 2353 0.285162691808209 3423 3333 L-type calcium channel blocker
SGTC_956 1185-0240 191 µM -0.568721586828739 0.293984276916066 no 2354 0.284772547914923 3419 1416193
SGTC_1910 st062352 60.4 µM -0.570233221353274 0.293502526657703 no 2355 0.284259763272584 3411 2245730
SGTC_2028 5153890 36.43 µM -0.570515108257603 0.293412731193849 no 2356 0.284164188962341 3449 2830968 YPR165W RHO1
SGTC_536 3852-0578 10.6 µM -0.570904901845281 0.293288582879354 no 2357 0.284032053999733 3507 2869208
SGTC_2421 5690543 90.72 µM -0.572015931647525 0.292934856242611 no 2358 0.283655590708596 3470 3397993
SGTC_674 0498-0004 451 µM -0.572193303282301 0.292878403476892 no 2359 0.283595511923718 3426 4231473
SGTC_571 k831-0106 44.2 µM -0.572771765673954 0.292694329081317 no 2360 0.283399619261849 3475 4783639
SGTC_1946 st076057 65.1 µM -0.572800109161268 0.29268531118929 no 2361 0.28339002258496 3398 953009
SGTC_1716 st033144 30.6155 µM -0.573588420387559 0.292434550250903 no 2362 0.283123174750933 3539 674617
SGTC_519 k048-0011 62.8 µM -0.573777564329318 0.292374398630088 no 2363 0.283059166390939 3448 6836379
SGTC_2213 7173844 200 µM -0.574423622933389 0.292168982251134 no 2364 0.282840585550032 3423 892728
SGTC_2110 5483698 200 µM -0.576539854075195 0.291496590564091 no 2365 0.282125169867032 3435 2848765 YHR062C RPP1
SGTC_410 α-linolenic acid 100 µM -0.57802423632431 0.291025387780766 no 2366 0.281623878202436 3521 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2300 7976697 71.57 µM -0.578802952529594 0.290778334242907 no 2367 0.281361069347683 3393 2236109
SGTC_2857 9024691 58.44 µM -0.580399362687611 0.290272167998447 no 2368 0.280822667407701 3471 16478292
SGTC_1853 st056710 91.2 µM -0.580463694782721 0.290251779177623 no 2369 0.280800981345919 3551 269167
SGTC_159 3970-0959 50 µM -0.580480060478312 0.290246592492057 no 2370 0.280795464672273 3583 6615653
SGTC_826 1683-5028 118 µM -0.581734582268524 0.289849133417352 no 2371 0.280372736945791 3483 722377
SGTC_1773 st048542 73.5835 µM -0.585293867626619 0.288722868376814 no 2372 0.279175068774312 3408 3237138
SGTC_435 c-PAF 6.7 µM -0.587962974475404 0.287879637057729 no 2373 0.278278572621419 3450 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2288 7946289 167.31 µM -0.588529482474001 0.287700814076358 no 2374 0.278088475359678 3545 1246052
SGTC_2402 5553605 200 µM -0.588924457669467 0.287576167920592 no 2375 0.277955975086579 3545 6758546
SGTC_1981 st071826 47 µM -0.589308206569417 0.287455089012221 no 2376 0.277827270356237 3464 11838600
SGTC_341 1486-1430 230 µM -0.590350535033736 0.287126339463053 no 2377 0.277477832935673 3440 2054753 YPL210C SRP72
SGTC_1450 4112-4260 37.6 µM -0.591981236588302 0.286612374905737 no 2378 0.276931576545159 3528 1633175
SGTC_1674 st016616 23.6 µM -0.592035631479934 0.286595238245323 no 2379 0.276913364290155 3466 625830
SGTC_1767 st044992 70.3 µM -0.592754798378218 0.286368716366364 no 2380 0.276672631187047 3452 9600693
SGTC_88 0180-0332 8.668 µM -0.594650213521818 0.285772109463308 no 2381 0.27603865385258 3520 3101745
SGTC_1762 st045503 25.4615 µM -0.595049923963768 0.285646370852921 no 2382 0.275905050073104 3492 4645554
SGTC_3068 9116768 49.47 µM -0.59571374811709 0.285437607053956 no 2383 0.275683236121501 3500 41904888
SGTC_2750 bromebric acid 70.15 µM -0.59784583432913 0.284767586363517 no 2384 0.274971402286139 3533 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1363 1636-0063 10.4 µM -0.598778948491669 0.284474586039494 no 2385 0.274660151137334 3519 6072185
SGTC_978 1416-0512 87.4 µM -0.598973759782193 0.284413432953712 no 2386 0.274595191483228 3518 6814003
SGTC_2278 7948257 134.34 µM -0.598986522319174 0.284409426893246 no 2387 0.274590936090979 3512 1247028
SGTC_2659 sanguinarine 24.21 µM -0.599304377170378 0.284309663441629 no 2388 0.274484964752595 3457 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_361 000s-0510 1.45 µM -0.600220776711105 0.284022131539732 no 2389 0.274179554391216 3474 660
SGTC_1142 3253-1408 9.78 µM -0.603016971795312 0.283145651021237 no 2390 0.273248699410867 3524 256655
SGTC_3253 9135987 49.47 µM -0.604071708247292 0.282815376338263 no 2391 0.272897984119611 3506 4182430
SGTC_2582 agaric acid 100 µM -0.605179685363804 0.282468629573525 no 2392 0.272529806114098 3506 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_254 nsc-64875 3.808 µM -0.605189036964893 0.282465703815274 no 2393 0.272526699650479 3542 56993
SGTC_879 0831-1030 162 µM -0.605922695294598 0.282236215620691 no 2394 0.27228304400768 3562 1549252
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.606682953253243 0.281998501776345 no 2395 0.272030668600717 3526 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1235 benzylparaben 21.5 µM -0.606692357237234 0.281995561987217 no 2396 0.272027547580505 3504 7180
SGTC_2645 abamectin 100 µM -0.607195591780044 0.281838266851773 no 2397 0.271860558685146 3525 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_253 dyclonine 31.25 µM -0.609612232550695 0.281083491310015 no 2398 0.271059353242496 3564 3180 An oral anasthetic.
SGTC_133 0724-0033 378.92 µM -0.610277572641623 0.280875861017765 no 2399 0.270838975433303 3431 280309
SGTC_2764 methyldopa 94.69 µM -0.61204765256586 0.280323839821236 no 2400 0.270253115057306 3580 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.612450315505486 0.280198337826214 no 2401 0.270119930357227 3483 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1964 st076914 61 µM -0.61478521616985 0.279471133007667 no 2402 0.269348286922616 3558 24208661
SGTC_7 0192-1582 4.227 µM -0.615100982216326 0.279372858074144 no 2403 0.269244016729934 3571 252616
SGTC_1035 k081-0041 55.2 µM -0.615681680159235 0.279192173006222 no 2404 0.269052315331917 3584 731709
SGTC_1469 k284-2957 126 µM -0.616947944383648 0.278798370013451 no 2405 0.268634530835635 3548 23884841
SGTC_911 3456-4043 236 µM -0.617478428731485 0.278633471941158 no 2406 0.268459602591946 3553 914281
SGTC_2337 9009472 200 µM -0.618007793378286 0.278468969278849 no 2407 0.268285100681139 3599 5742383
SGTC_1106 tegaserod maleate 11.7 µM -0.618544875912136 0.278302116618637 no 2408 0.268108112948438 3512 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2036 5160441 105 µM -0.618964449923533 0.278171803641535 no 2409 0.267969889338754 3564 134534 YIL048W NEO1
SGTC_2730 imipramine 71.33 µM -0.619543644999218 0.277991963821423 no 2410 0.26777913946475 3568 3696 A tricyclic antidepressant.
SGTC_2150 5556613 200 µM -0.620044586154386 0.277836467578072 no 2411 0.267614216624952 3534 743190
SGTC_2879 9041815 71.43 µM -0.620508669548446 0.277692450188214 no 2412 0.267461474020874 3512 4942971
SGTC_3187 9109394 49.47 µM -0.621756855741319 0.277305285909312 no 2413 0.267050879892933 3502 17098090
SGTC_1630 st005209 31.3 µM -0.621980833433822 0.277235840115327 no 2414 0.266977235537803 3568 3367314
SGTC_14 0354-0009 295 µM -0.622571901175833 0.277052616433047 no 2415 0.266782940434807 3571 1713507
SGTC_2408 sulbentine 18.36 µM -0.622702741061947 0.277012065701485 no 2416 0.266739940560965 3432 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1656 st012921 11 µM -0.623015683315791 0.27691508842948 no 2417 0.266637107866068 3504 6732821
SGTC_2760 etidronate 98.04 µM -0.623878380024583 0.276647834569536 no 2418 0.266353729910613 3536 3305 A chelator and antioxidant.
SGTC_2236 dapsone 200 µM -0.624241600364102 0.276535350767877 no 2419 0.266234465177078 3573 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_992 3909-8734 162 µM -0.624844156850704 0.276348797675529 no 2420 0.266036673178038 3526 4288319
SGTC_994 3910-0338 138 µM -0.625255537081681 0.276221468732511 no 2421 0.265901678449484 3610 3479481
SGTC_1068 loratadine 26.9 µM -0.625653272925615 0.276098390331884 no 2422 0.265771194146923 3538 3957 A H1 histamine antagonist.
SGTC_1817 st052116 64.4 µM -0.629533386043751 0.274899113098474 no 2423 0.264499959361214 3577 4361398
SGTC_202 3594-0513 34.79 µM -0.629579111404077 0.274884995483237 no 2424 0.264484996907071 3530 708429
SGTC_330 1488-0319 80.1 µM -0.630024601021711 0.274747470140043 no 2425 0.264339244372573 3535 6846614
SGTC_790 1575-0012 79.1 µM -0.63015946604192 0.274705843181901 no 2426 0.264295128135207 3592 378741 YLR208W SEC13
SGTC_2973 9094665 17.96 µM -0.630450695287515 0.274615964007612 no 2427 0.264199875759082 3592 25237061 YIL048W NEO1
SGTC_1959 st077091 55.8 µM -0.631288031527673 0.274357626118411 no 2428 0.263926105555128 3572 821356 YKL052C ASK1
SGTC_2985 9022375 71.43 µM -0.632417270501636 0.27400941948517 no 2429 0.263557125807141 3620 4939335
SGTC_2515 chrysin 20.77 µM -0.633024040414991 0.273822409115783 no 2430 0.263358972024856 3540 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1052 3253-3998 198 µM -0.633801152039793 0.273582990555677 no 2431 0.263105300633522 3551 5450317
SGTC_93 0109-0045 59.227 µM -0.634249909429178 0.273444781107211 no 2432 0.262958870313915 3636 88733
SGTC_451 chloral hydrate 100 µM -0.634487409936568 0.273371649084172 no 2433 0.262881390345797 3611 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_3075 9116269 49.47 µM -0.635965638611373 0.272916685377792 no 2434 0.262399409269474 3603 17015205 YNL244C SUI1
SGTC_1447 4239-0816 81.9 µM -0.635977421313857 0.272913060450516 no 2435 0.262395569301071 3501 1341554
SGTC_667 1498-1044 59 µM -0.636250240192331 0.272829134889316 no 2436 0.26230666600764 3570 6739982
SGTC_2008 4012253 172 µM -0.637731327449731 0.272373740823351 no 2437 0.261824294531998 3581 603940
SGTC_2310 7668677 200 µM -0.639438582150691 0.271849275318316 no 2438 0.261268828230433 3623 2197143
SGTC_2413 inermin 26.06 µM -0.640419428803849 0.271548188459723 no 2439 0.260949977517859 3651 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1361 1608-0041 5.61 µM -0.640578482870528 0.271499379876302 no 2440 0.260898291556904 3573 X1361
SGTC_378 3970-0959 8.33 µM -0.640745181730506 0.271448230041694 no 2441 0.260844127007446 3580 6615653
SGTC_2539 epi(13)torulosol 80 µM -0.641966016723262 0.27107377573565 no 2442 0.260447624148376 3551 6708597
SGTC_572 0960-0087 17.7 µM -0.642178584173753 0.271008603426415 no 2443 0.260378618221459 3539 6796365
SGTC_3138 9097216 49.47 µM -0.643680683857018 0.270548288712849 no 2444 0.259891259058776 3612 25237486
SGTC_643 k048-0106 28.4 µM -0.64394388115929 0.270467672787698 no 2445 0.259805912657228 3594 6763920
SGTC_3269 9137823 49.47 µM -0.643953702397928 0.270464664827187 no 2446 0.259802728226008 3519 17682936
SGTC_3287 9117173 37.0625 µM -0.644432391762039 0.270318076426189 no 2447 0.259647542753541 3556 2789709
SGTC_477 mead ethanolamide 10 µM -0.645564588754566 0.269971523404139 no 2448 0.259280688303801 3475 16061185
SGTC_127 0180-0333 59.125 µM -0.645722467906736 0.269923216005824 no 2449 0.259229553591701 3577 771601
SGTC_166 k072-0058 166.424 µM -0.646086555765841 0.269811829970244 no 2450 0.259111650815535 3610 5846229
SGTC_1687 st020778 55.3625 µM -0.646231929710836 0.269767361895072 no 2451 0.259064582035523 3592 4259299
SGTC_2119 5528445 120.635 µM -0.647547806275469 0.269365018714289 no 2452 0.258638732327567 3599 791935
SGTC_2377 9073351 62.6 µM -0.647785833650094 0.269292271474028 no 2453 0.258561739597932 3550 7337946 YHR072W ERG7
SGTC_3097 9117246 49.47 µM -0.649303382175459 0.268828701696839 no 2454 0.258071150035459 3620 16423892
SGTC_797 k781-0471 270 µM -0.649511141706589 0.268765268017719 no 2455 0.258004023603832 3577 23738129
SGTC_2898 9056270 58.44 µM -0.649736947826032 0.268696332835174 no 2456 0.257931076649917 3533 19154699
SGTC_1290 0986-0249 10.2 µM -0.650773464104238 0.2683800141623 no 2457 0.257596366088952 3557 53329
SGTC_2391 6285546 200 µM -0.654633094590787 0.267203801514827 no 2458 0.256352005549405 3565 846083
SGTC_1942 st076330 65.2 µM -0.654939654790187 0.26711048972249 no 2459 0.256253303766363 3651 24208414
SGTC_2196 6573537 42.6665 µM -0.655404155885251 0.266969134721064 no 2460 0.256103788236718 3638 2903087
SGTC_745 0469-0705 296 µM -0.655818050104041 0.266843212029309 no 2461 0.255970600600243 3683 3486736
SGTC_250 brefeldin a 552.239 µM -0.65637115618642 0.266674982544956 no 2462 0.255792672202547 3514 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_414 piperonyl butoxide 100 µM -0.659466390658377 0.265734544894478 no 2463 0.254798160739427 3584 5794 A potent inhibitor of cytochrome P450.
SGTC_1195 1502-0147 41.1 µM -0.659881782183042 0.265608462884355 no 2464 0.254664847969501 3628 817940
SGTC_1685 st024049 53.0905 µM -0.660303037129094 0.265480632166909 no 2465 0.254529690749835 3606 1941139
SGTC_1972 st070201 17.4 µM -0.660856290770289 0.265312793591924 no 2466 0.254352239615096 3598 2829099
SGTC_1962 st076595 64.5 µM -0.661394956705766 0.265149432203332 no 2467 0.254179529680646 3636 279619
SGTC_2698 st077697 67.5 µM -0.661536883061505 0.265106398657022 no 2468 0.254134034737222 3561 3154499
SGTC_768 0384-0033 77.3 µM -0.661777688972194 0.265033391918539 no 2469 0.254056853410761 3598 3965305 YMR134W ERG29
SGTC_3030 9087619 49.47 µM -0.662234669253449 0.264894874239899 no 2470 0.253910419293901 3583 25236973
SGTC_1407 3909-7909 12.3 µM -0.662851269432823 0.264708031676208 no 2471 0.253712907031374 3634 4411780
SGTC_203 k066-0004 30.888 µM -0.66361075865964 0.264477982936791 no 2472 0.253469734814996 3681 6795412
SGTC_2743 auranofin 4.32 µM -0.664411185222644 0.264235644470233 no 2473 0.253213587953999 3572 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_196 k015-0023 18.111 µM -0.666604686568403 0.263572116442258 no 2474 0.252512337374745 3611 5211998
SGTC_3041 9091929 49.47 µM -0.667370823324498 0.263340562715394 no 2475 0.252267648915329 3678 25236887
SGTC_1402 3909-7673 35.9 µM -0.669467991429563 0.262707255819951 no 2476 0.251598496201696 3618 5328014
SGTC_558 k064-0027 21.3 µM -0.671183969673283 0.262189641591787 no 2477 0.251051669716378 3640 5088526
SGTC_2571 chrysanthemic acid 100 µM -0.673129883119399 0.261603301744718 no 2478 0.250432332006412 3581 2743 An insecticide.
SGTC_2565 isoliquiritigenin 100 µM -0.673231152300058 0.261572805894511 no 2479 0.25040012263047 3582 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_122 0236-0016 402.397 µM -0.673941375876565 0.261358982914413 no 2480 0.250174292734158 3689 6808838
SGTC_3089 9117425 49.47 µM -0.674490759476595 0.261193644716788 no 2481 0.249999679274407 3579 9401657
SGTC_334 1502-1024 68.5 µM -0.675655972997511 0.260843149133243 no 2482 0.249629547518215 3663 3296216
SGTC_26 0302-0163 425.158 µM -0.676469090983449 0.260598707096466 no 2483 0.249371431955682 3650 3100915
SGTC_3080 9117754 49.47 µM -0.67711104861207 0.260405803148568 no 2484 0.249167749669184 3691 9550191
SGTC_1944 st076371 56.9 µM -0.677761291896122 0.260210484423069 no 2485 0.248961528722465 3624 24208455
SGTC_1283 0922-0125 16.4 µM -0.678550993430396 0.25997337708581 no 2486 0.248711201576768 3642 3360884
SGTC_1269 0831-0796 3.05 µM -0.678800467844519 0.259898495733082 no 2487 0.248632148660608 3634 927758
SGTC_2082 5219693 150 µM -0.679778095410392 0.259605161784028 no 2488 0.248322489172968 3649 2834649
SGTC_18 0111-0177 500 nM -0.680284118824202 0.259453398276231 no 2489 0.248162289138738 3727 721752
SGTC_1346 1488-2224 62.4 µM -0.68078054985878 0.259304556199632 no 2490 0.248005179499155 3642 3722427
SGTC_1731 st035964 63 µM -0.681185942993405 0.259183042231125 no 2491 0.247876920753852 3630 6739575
SGTC_801 0866-0028 10.1 µM -0.681445165539487 0.259105357381908 no 2492 0.247794926188647 3672 6849771
SGTC_731 3966-0296 387 µM -0.681556248805521 0.259072071189752 no 2493 0.247759793924169 3679 660956
SGTC_2949 9072542 2.23 µM -0.682582054425282 0.258764792212511 no 2494 0.247435488469527 3666 16457352
SGTC_748 act1.228 77.9 µM -0.682930342970601 0.258660505660839 no 2495 0.247325429672645 3615 4421505 YNR035C ARC35
SGTC_290 2043-6722 48.1 µM -0.684701214838248 0.258130597828431 no 2496 0.2467662411465 3651 773758 YLR208W SEC13
SGTC_2347 9049783 174.81 µM -0.685945501208101 0.257758600088389 no 2497 0.24637373789247 3639 6467988 YPL169C MEX67
SGTC_739 1486-1183 203 µM -0.686117300370545 0.25770726006921 no 2498 0.24631957109873 3642 4346692
SGTC_2102 5377816 72.7585 µM -0.686834329367822 0.257493042299159 no 2499 0.246093566981812 3667 1379702
SGTC_1416 3966-0321 25.3 µM -0.68815710964375 0.257098094668861 no 2500 0.245676924991624 3662 582530 YLR208W SEC13
SGTC_1305 1181-0477 144 µM -0.688584581260733 0.256970530199871 no 2501 0.245542363383719 3654 6252086
SGTC_705 1124-0212 310 µM -0.689935222265482 0.256567693489951 no 2502 0.245117462299899 3647 9554485
SGTC_149 3970-0822 46.1 µM -0.691211704268472 0.256187277688241 no 2503 0.244716254813849 3711 3114250 YBL034C STU1
SGTC_2354 9060492 162 µM -0.692988172131272 0.255658346512045 no 2504 0.24415848711735 3688 6471895
SGTC_2193 5925765 200 µM -0.693386319650621 0.255539879084492 no 2505 0.244033572583698 3657 877370
SGTC_615 k087-0205 167 µM -0.69375958498784 0.255428841315067 no 2506 0.243916495884318 3656 9642773
SGTC_1292 0kpi-0043 232 µM -0.694303151340833 0.255267188050999 no 2507 0.243746057563907 3671 3333905
SGTC_2339 9000433 200 µM -0.695670310358981 0.254860839993023 no 2508 0.243317661433945 3661 2988954
SGTC_538 2922-0838 53.3 µM -0.697457994090745 0.254330014486403 no 2509 0.242758109332167 3698 777039
SGTC_1368 1852-0141 284 µM -0.697481155539469 0.254323140851369 no 2510 0.24275086428007 3642 2838987
SGTC_1002 4049-0206 172 µM -0.698046564311045 0.254155374409472 no 2511 0.242574037038976 3700 4662749
SGTC_2006 4011487 200 µM -0.69974927211978 0.253650502707028 no 2512 0.242041949859845 3713 45595294
SGTC_479 n-linoleoylglycine 10 µM -0.700196424220741 0.253518004543741 no 2513 0.241902322204375 3687 6433346 An anti-infammatory.
SGTC_67 0335-0847 266 µM -0.701968648244442 0.252993224726977 no 2514 0.241349357824828 3763 4552207 YOR254C SEC63
SGTC_773 4358-1457 44.6 µM -0.704286243800475 0.252307816402437 no 2515 0.240627265662117 3679 1186886
SGTC_2704 st078022 71.1 µM -0.705809270249667 0.2518579284783 no 2516 0.240153378154608 3697 54697681
SGTC_2443 5493264 126.67 µM -0.708086268394802 0.2511861149049 no 2517 0.239445843198721 3707 5340055
SGTC_1176 0848-0131 83.3 µM -0.708449822820756 0.251078938332466 no 2518 0.239332980879133 3760 6769040
SGTC_688 0527-0193 473 µM -0.709692032331664 0.250712915115242 no 2519 0.238947567071823 3719 4007154
SGTC_1571 st070080 73.4 µM -0.709998069254463 0.250622783215807 no 2520 0.238852666737908 3748 4315245
SGTC_471 1-acyl-paf 4 µM -0.711019569933637 0.250322062130699 no 2521 0.238536054394828 3650 16759367
SGTC_883 0850-0245 24.6 µM -0.712176213476131 0.249981787212428 no 2522 0.23817783227103 3750 6823229 YPR165W RHO1
SGTC_1029 k015-0030 64.7 µM -0.713005883912087 0.249737856331324 no 2523 0.237921058094477 3753 2208316
SGTC_1051 3253-3903 78 µM -0.714914691445422 0.249177129298722 no 2524 0.237330879175079 3705 5509239
SGTC_2184 6075246 200 µM -0.714933755294308 0.249171532524157 no 2525 0.237324988933822 3740 2267320
SGTC_2461 5755302 26.15 µM -0.717839775604508 0.248319164044322 no 2526 0.236428042512045 3689 2788904
SGTC_2248 tofa 1.1 µM -0.718106231044917 0.248241087536289 no 2527 0.236345894234648 3643 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1236 0330-0013 258 µM -0.718293107125335 0.248186337103853 no 2528 0.236288289670146 3704 4617066
SGTC_1314 1222-0010 41.1 µM -0.719051892300862 0.247964096517508 no 2529 0.236054473531223 3722 3526027
SGTC_407 eburnamonine 100 µM -0.719129801291207 0.247941283766991 no 2530 0.236030473455182 3603 3195
SGTC_2788 5282734 71.43 µM -0.719949193676992 0.247701423030613 no 2531 0.2357781388559 3751 743706
SGTC_758 0868-0029 16 µM -0.721088703285132 0.247368060478074 no 2532 0.235427470492307 3733 762687
SGTC_1226 3909-7979 35.4 µM -0.721875722275781 0.247137958837721 no 2533 0.235185444399637 3723 6615510
SGTC_3039 9090270 49.47 µM -0.722000769891525 0.247101409066306 no 2534 0.235147002090956 3684 17173750
SGTC_1885 st057546 99.9 µM -0.722322655893877 0.247007339328716 no 2535 0.235048063422477 3764 702008
SGTC_2971 9092186 9.93 µM -0.7233046792374 0.246720465859408 no 2536 0.234746359324786 3710 25236400
SGTC_728 3030-5151 22.5 µM -0.724701734181608 0.246312658957172 no 2537 0.234317515505488 3739 3125388
SGTC_2499 avocadenofuran 51.48 µM -0.724806326949784 0.246282142382442 no 2538 0.234285426878257 3711 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_1792 st045773 43.6 µM -0.724941991724182 0.246242563084097 no 2539 0.234243809112326 3641 2919270
SGTC_3021 9087658 49.47 µM -0.725088261795431 0.246199893581738 no 2540 0.23419894255393 3686 25237042
SGTC_214 4373-3496 70 µM -0.725825130111412 0.245984996697223 no 2541 0.233972989568692 3784 3779166
SGTC_1351 1496-0003 46.5 µM -0.726899038889345 0.245671987191038 no 2542 0.233643903000977 3735 3891978
SGTC_1904 st060225 78 µM -0.727784468634713 0.245414074158663 no 2543 0.233372766726276 3695 66595
SGTC_258 haloperidol 50.781 µM -0.727936903849275 0.245369686644809 no 2544 0.233326105639379 3742 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1682 st012968 530 nM -0.728348905787582 0.245249737654826 no 2545 0.233200015950211 3726 24207270
SGTC_219 mitoxanthrone 164.414 µM -0.728365610257436 0.245244875031411 no 2546 0.233194904487242 3721 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2831 7999036 19.48 µM -0.728599303080391 0.245176853154103 no 2547 0.233123402470788 3743 2988270
SGTC_1812 st052057 4.327 µM -0.72889888097997 0.245089668692735 no 2548 0.233031759678439 3733 3645418
SGTC_3069 9117009 49.47 µM -0.730472437552906 0.244631999374942 no 2549 0.232550727336256 3633 41904981
SGTC_1147 3809-1045 12.3 µM -0.73066387601329 0.244576350871152 no 2550 0.23249224276668 3697 325925
SGTC_1482 3346-2049 8.48 µM -0.730742168937608 0.244553594169124 no 2551 0.232468326586 3745 3826804
SGTC_1688 st021091 57.6 µM -0.731019250270035 0.244473066585084 no 2552 0.232383697396096 3751 3656366
SGTC_1906 st060206 94.7 µM -0.731606018190886 0.244302582588256 no 2553 0.232204536949786 3706 5133468
SGTC_1494 4358-1428 177 µM -0.731869775585632 0.244225969398646 no 2554 0.232124027786151 3737 1564571
SGTC_3205 9113483 49.47 µM -0.731962253432623 0.244199110573235 no 2555 0.23209580357773 3764 17018033
SGTC_1399 3562-5772 25 µM -0.732208009660299 0.244127742045284 no 2556 0.232020808142662 3679 23847490
SGTC_2069 5228469 200 µM -0.732264984772063 0.244111197865935 no 2557 0.232003423436568 3695 2835210
SGTC_2916 7875993 68.79 µM -0.732742452171459 0.243972576776073 no 2558 0.231857763238632 3692 1299250
SGTC_2983 9022671 12.99 µM -0.733216057364701 0.243835118948909 no 2559 0.231713331612866 3725 6405161
SGTC_3249 9135183 49.47 µM -0.733290167029718 0.243813613352627 no 2560 0.231690735512091 3737 4902779
SGTC_2663 amphotericin b 100 µM -0.733820556096985 0.243659731691241 no 2561 0.231529055272729 3725 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_206 4546-0025 72.014 µM -0.735625447227146 0.243136472124536 no 2562 0.230979335847017 3743 6620745 YIL048W NEO1
SGTC_1717 st033143 58.0435 µM -0.735719200079303 0.243109308659458 no 2563 0.230950801267445 3723 674616
SGTC_3199 9111318 49.47 µM -0.73591684151807 0.243052050430859 no 2564 0.230890653648288 3696 8548020
SGTC_1926 methyl fluorone black 53.6 µM -0.737216854910145 0.242675608492575 no 2565 0.230495242573812 3570 72721 Reacts with homocysteine.
SGTC_704 1310-0270 142 µM -0.738776203618909 0.242224488116069 no 2566 0.230021451950686 3705 5718033
SGTC_283 0987-0079 11.7 µM -0.73926927629082 0.242081936590834 no 2567 0.229871750837454 3762 411556
SGTC_561 1550-0330 72.9 µM -0.741134770865629 0.241543018037985 no 2568 0.229305864428102 3701 6812934
SGTC_2322 7413319 38.22 µM -0.741347705784314 0.241481545199237 no 2569 0.229241321616319 3796 1840400
SGTC_2770 toltrazuril 17.5 µM -0.741649143848938 0.24139453664484 no 2570 0.229149969990622 3707 68591 Kills coccidiodes.
SGTC_2329 6138490 200 µM -0.74169626763783 0.2413809361439 no 2571 0.229135690843767 3810 720019
SGTC_1806 st050005 60.3 µM -0.742711760656832 0.241087953626995 no 2572 0.228828103972744 3752 5194765
SGTC_2536 dehydroabietamide 32.04 µM -0.744711218583502 0.240511650416246 no 2573 0.228223157857352 3749 3983547
SGTC_1468 k284-1086 134 µM -0.744887456547387 0.240460889395583 no 2574 0.22816987931919 3747 15996457
SGTC_2521 angolensin 13.4 µM -0.744920865587393 0.240451267399362 no 2575 0.228159780213399 3777 821428 A flavenoid.
SGTC_2141 5621638 7.665 µM -0.745098269786484 0.240400177480023 no 2576 0.228106157508458 3763 2856238
SGTC_120 rhodamine 6G 52.259 µM -0.747888500348542 0.23959740860612 no 2577 0.227263707227885 3788 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2186 6124449 200 µM -0.748813591938792 0.2393315766349 no 2578 0.226984783168532 3718 3834182 YLR033W RSC58
SGTC_1841 st054148 70 µM -0.74900175707497 0.239277525703499 no 2579 0.226928073196158 3769 675442
SGTC_1329 1447-1697 50.6 µM -0.749099438884159 0.239249468976167 no 2580 0.226898636607326 3774 2840515
SGTC_932 2857-0803 154 µM -0.749120777039 0.239243340348637 no 2581 0.226892206602639 3856 674898
SGTC_2020 4017018 200 µM -0.749608249797935 0.239103354468311 no 2582 0.226745340356078 3833 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_2567 aureobasidin a 60 nM -0.750313716107787 0.238900847428938 no 2583 0.226532891828402 3882 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_2935 9038016 29.96 µM -0.75056699264227 0.238828166234514 no 2584 0.226456645976222 3753 6463195
SGTC_3260 9137109 49.47 µM -0.751721766756149 0.238496941210062 no 2585 0.226109198837573 3622 17478346
SGTC_459 nigericin 15.3 µM -0.751878092509068 0.238452121471034 no 2586 0.226062186884548 3794 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_421 streptovitacin 30 mM -0.751881376416948 0.238451180000036 no 2587 0.226061199371887 3848 91467 include heat shock
SGTC_1359 1582-0056 520 nM -0.751993435877038 0.238419054638981 no 2588 0.226027503135228 3836 3661189
SGTC_702 1488-0190 94 µM -0.75248324499033 0.238278663307333 no 2589 0.22588025105457 3786 949357
SGTC_2989 9073649 71.4286 µM -0.754150410825111 0.237801152149292 no 2590 0.22537945514404 3726 21367202
SGTC_1296 1068-0102 11.9 µM -0.754547200527683 0.237687580651781 no 2591 0.225260357126897 3767 767053
SGTC_3180 9109287 49.47 µM -0.75502020429562 0.237552233602704 no 2592 0.22511842973551 3777 18891271
SGTC_3165 9101544 49.47 µM -0.757493611152588 0.236845173168807 no 2593 0.224377096024599 3775 5002184
SGTC_2204 7233102 200 µM -0.757538202056683 0.236832436817852 no 2594 0.224363743891076 3688 2172480
SGTC_2360 9040895 200 µM -0.758193081504713 0.23664542917524 no 2595 0.224167701196774 3790 4914414
SGTC_2389 9091542 195.52 µM -0.758928233162823 0.236435595784577 no 2596 0.223947744402522 3783 3626624 YOL127W RPL25
SGTC_973 1325-0077 65.9 µM -0.760571877428305 0.235966823191589 no 2597 0.223456411201585 3805 2835149
SGTC_286 k060-0067 22.9 µM -0.760999025222971 0.235845083182527 no 2598 0.223328824736944 3757 5985051
SGTC_3213 9129884 49.47 µM -0.761644745161353 0.235661114387481 no 2599 0.22313603081993 3763 17190742
SGTC_3309 9129340 25.759 µM -0.762330362834907 0.235465865197156 no 2600 0.222931428316834 3820 17158987
SGTC_513 4245-1575 41.7 µM -0.762803744994198 0.235331108235532 no 2601 0.222790223672406 3733 719745
SGTC_16 erodoxin 22.806 µM -0.763052668368705 0.235260264688976 no 2602 0.222715993043192 3797 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_3095 9117207 49.47 µM -0.763275375962517 0.235196892130101 no 2603 0.222649592085723 3764 17015229
SGTC_1700 st030840 7.9285 µM -0.763304559021139 0.235188588643534 no 2604 0.222640891902929 3816 5499307
SGTC_1169 aniline yellow 25.8 µM -0.763889691246697 0.23502213451953 no 2605 0.222466490592674 3713 6051 A DNA damaging agent.
SGTC_671 0560-0003 407 µM -0.764329984745239 0.234896925979248 no 2606 0.222335310505834 3708 3238678
SGTC_3054 9094397 49.47 µM -0.766168330297751 0.234374544634589 no 2607 0.221788074829711 3794 2598354
SGTC_1503 4585-0012 61.3 µM -0.766388728184622 0.234311959908415 no 2608 0.221722518841242 3788 2922052
SGTC_1031 k035-0009 16 µM -0.768042310944053 0.233842699637697 no 2609 0.221231024131798 3856 5180959
SGTC_2715 st079500 56.4 µM -0.76989050293937 0.233318829298992 no 2610 0.220682423965574 3731 28246688
SGTC_1138 3761-0006 1.03 µM -0.772996203846388 0.232439986321345 no 2611 0.219762313637958 3753 12061087
SGTC_1789 tunicamycin 25 nM -0.773024976258311 0.232431852997295 no 2612 0.219753799689706 3743 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_3183 9108214 49.47 µM -0.773303307382125 0.232353183120728 no 2613 0.219671449433471 3734 4974831
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.774203142272227 0.232098947513192 no 2614 0.219405335186133 3812 23847180
SGTC_1268 0828-0275 2.46 µM -0.775295876183951 0.231790419326576 no 2615 0.219082422793313 3857 745337
SGTC_1279 0874-0590 65.2 µM -0.775826475660796 0.23164068955101 no 2616 0.21892572464241 3838 3523074
SGTC_2981 9013952 38.96 µM -0.776981313203404 0.231314992548912 no 2617 0.218584897682893 3718 2996344
SGTC_1908 st060353 56.5 µM -0.783227829986378 0.229557731777363 no 2618 0.216746667497905 3834 4227716
SGTC_1258 0671-0043 57.1 µM -0.783674589667906 0.229432337257821 no 2619 0.216615538128406 3831 4298767
SGTC_598 3937-0236 20.2 µM -0.783955266208609 0.229353577854138 no 2620 0.216533179646423 3875 1379313
SGTC_979 1426-2828 121 µM -0.785878373189824 0.2288143511564 no 2621 0.215969372881611 3929 747872
SGTC_121 0557-0495 61.343 µM -0.786656064055 0.228596493935291 no 2622 0.215741615149098 3941 3104427
SGTC_1903 st060211 78.3 µM -0.787793428855296 0.228278089892769 no 2623 0.215408772673282 3869 688960
SGTC_2115 tiliquinol 12.7705 µM -0.787994604393489 0.228221796976369 no 2624 0.215349930970959 3811 71208 A bioactive hydroxyquinoline.
SGTC_2625 euphol 100 µM -0.789426241246716 0.227821421961 no 2625 0.214931461854993 3811 6708538 A triterpene alcohol.
SGTC_1874 staurosporine 7.6 µM -0.789469318832485 0.227809380908177 no 2626 0.214918877550301 3864 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_3297 9117502 71.43 µM -0.789779922231106 0.227722571604143 no 2627 0.214828153290225 3826 7453720
SGTC_347 4534-1311 26.2 µM -0.79193373175367 0.227121124452417 no 2628 0.21419965861351 3818 2862016
SGTC_1006 4099-6547 255 µM -0.793999691475753 0.226545051590554 no 2629 0.213597805479683 3864 3146833
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.794721580484979 0.226343954473199 no 2630 0.213387738076023 3818 77254
SGTC_495 decylubiquinone 155 µM -0.796957368051997 0.22572176972677 no 2631 0.212737895605819 3849 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_606 k015-0008 38.6 µM -0.798486063693515 0.225296915137184 no 2632 0.212294238671951 3864 1970475
SGTC_1062 mesoridazine 14.2 µM -0.799360002611891 0.225054233912791 no 2633 0.212040847878638 3838 4078 A neuroleptic.
SGTC_1034 k072-0165 12.7 µM -0.799706166174217 0.224958149862826 no 2634 0.211940529764793 3836 5835461
SGTC_1794 st048918 76.9 µM -0.799714122110597 0.224955941820028 no 2635 0.211938224462824 3729 672303
SGTC_2289 7946404 165.07 µM -0.800905726469706 0.224625369832298 no 2636 0.211593112347188 3863 1246120 YPR165W RHO1
SGTC_1850 st056238 17 µM -0.801750258691379 0.224391248706175 no 2637 0.211348718495415 3844 5393177
SGTC_2839 9003951 25.97 µM -0.802147688643329 0.224281121162841 no 2638 0.211233765985787 3867 2990634
SGTC_336 4111-0029 111 µM -0.802498932835594 0.22418381720812 no 2639 0.211132202731073 3821 3131175
SGTC_323 4013-0906 34.3 µM -0.8025975554015 0.224156500453509 no 2640 0.211103690882989 3863 2910086
SGTC_939 1165-0479 45.3 µM -0.804871311594258 0.2235272335 no 2641 0.210446972474799 3780 1377347
SGTC_2811 7967822 32.47 µM -0.805235265094758 0.223426601952329 no 2642 0.210341964932404 3920 2232244
SGTC_2918 7977171 22.06 µM -0.809093989872903 0.222361268031464 no 2643 0.20923054252487 3769 2236483
SGTC_2853 9015042 58.44 µM -0.811512917556831 0.221694919951864 no 2644 0.208535588873505 3790 6457456
SGTC_1270 0831-1170 17.3 µM -0.811660130749846 0.221654403628716 no 2645 0.208493338763726 3844 6764716
SGTC_1119 parthenolide 318.541 nM -0.811824030359929 0.221609299813163 no 2646 0.208446305599698 3987 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_762 1165-0429 115 µM -0.813661201797915 0.221104084488369 no 2647 0.207919533216447 3802 5967793
SGTC_2362 9071156 126 µM -0.814592214980922 0.220848311142071 no 2648 0.207652884068088 3872 653133
SGTC_60 0986-0278 202 µM -0.817845783771884 0.219955803467957 no 2649 0.206722625707648 3756 3110598
SGTC_2395 5646831 180.19 µM -0.821146468986783 0.219052489467872 no 2650 0.205781421870311 3869 6808628
SGTC_70 0141-0289 43.283 µM -0.821416886004414 0.218978577844211 no 2651 0.205704424216906 3883 352408
SGTC_1832 st054113 55 µM -0.821761130574447 0.218884508090386 no 2652 0.205606429890804 3835 1251267
SGTC_2180 6301957 200 µM -0.823087388583222 0.218522306511652 no 2653 0.205229149995338 3817 845462
SGTC_1208 2323-2347 50.3 µM -0.823419017192403 0.218431792575525 no 2654 0.205134876107789 3862 5412760
SGTC_713 1488-1073 324 µM -0.824402777519828 0.218163414403846 no 2655 0.204855368595971 3812 3312542
SGTC_2763 lisinopril 49.32 µM -0.828350160014333 0.217088447907967 no 2656 0.203736111759177 3787 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_1081 sertraline 6 µM -0.828856581238019 0.216950759168402 no 2657 0.203592783363394 3884 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1997 st073024 93.8 µM -0.829654130816712 0.216734019137876 no 2658 0.203367181171339 3864 686268
SGTC_117 lucigenin 22.078 µM -0.831539346848642 0.216222195764505 no 2659 0.202834505017235 3916 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_156 3474-0145 5.642 µM -0.831801097176511 0.216151187696094 no 2660 0.202760612254556 3758 2265471
SGTC_1303 1160-0052 261 µM -0.832398497612467 0.215989174495414 no 2661 0.202592024896422 3851 3562476
SGTC_1146 3579-1023 7 µM -0.83319830216707 0.215772380087166 no 2662 0.202366449994685 3941 X1146
SGTC_1878 temozolomide 1 mM -0.834008332104439 0.215552942607914 no 2663 0.202138144317604 3785 5394 DNA alkylating agent.
SGTC_118 0083-0097 135.343 µM -0.836055581625182 0.214998919029814 no 2664 0.201561817608335 3927 5207356
SGTC_2493 resveratrol 26.09 µM -0.836260406882485 0.214943535068721 no 2665 0.201504210925476 3770 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_1007 4101-0031 70 µM -0.836409943506755 0.214903106174595 no 2666 0.201462160288049 3828 1146276
SGTC_889 0919-1524 82.7 µM -0.836576578126242 0.214858059850479 no 2667 0.201415307782525 3926 3905452
SGTC_1033 k072-0102 21.3 µM -0.837652944806221 0.21456721790103 no 2668 0.201112824094015 3846 5965931
SGTC_136 0097-0015 404.482 µM -0.839670949488952 0.214022555836839 no 2669 0.20054645328287 3888 4861337
SGTC_2274 7947094 46.08 µM -0.8402006034017 0.213879735002629 no 2670 0.200397960076698 3847 2971028
SGTC_882 0843-0131 351 µM -0.841559289553266 0.21351362002323 no 2671 0.200017342418743 3860 5425421
SGTC_1230 0170-0365 3.77 µM -0.841743135459525 0.213464108512189 no 2672 0.199965873864427 3966 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.841820171588445 0.213443363914465 no 2673 0.199944309593762 3898 6708760
SGTC_1783 st039459 87.517 µM -0.842783531954441 0.213184045612627 no 2674 0.199674759889581 4007 729761
SGTC_653 0203-0016 55.2 µM -0.843010131317543 0.213123076074337 no 2675 0.199611388818215 3929 295302
SGTC_916 4466-0038 42 nM -0.844425470543088 0.212742490673511 no 2676 0.199215847166531 3984 5722064 YGL116W CDC20
SGTC_2063 5246145 200 µM -0.847125529760419 0.212017544970056 no 2677 0.198462578268696 3952 711240
SGTC_490 phenamil 164 µM -0.848044165148741 0.211771228009105 no 2678 0.198206687488031 3871 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_923 1900-2434 73.3 µM -0.851122469675406 0.210947052993985 no 2679 0.197350662389538 3868 5910570
SGTC_2491 paeonol 100 µM -0.851211354581571 0.21092328321311 no 2680 0.197325978241587 3783 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2348 9022543 33.42 µM -0.851551095962342 0.210832443362199 no 2681 0.197231646177547 3950 3162678 YDL140C RPO21
SGTC_2576 guaiol 23.12 µM -0.85285410660595 0.210484257952305 no 2682 0.196870107308913 3875 227829
SGTC_309 k408-0051 1.48 µM -0.853380588696278 0.210343669255541 no 2683 0.196724141242372 3865 3640463
SGTC_2466 5983409 37.09 µM -0.853676599938747 0.210264648365017 no 2684 0.196642101534692 3917 2879657
SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.854858350825679 0.209949350983325 no 2685 0.196314785093996 3897 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1681 tripelennamine 100 µM -0.855288512009304 0.209834650718692 no 2686 0.19619572288011 3874 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_2598 perillyl alcohol 100 µM -0.85698635077517 0.209382290515385 no 2687 0.195726214010044 3939 10819 An apoptosis inducer.
SGTC_987 1497-1013 404 µM -0.857486812809896 0.209249060521694 no 2688 0.19558794986825 3866 1676435
SGTC_2695 st077686 51.995 µM -0.857781756292106 0.209170565817196 no 2689 0.195506492732915 3957 2876092
SGTC_3073 9114972 49.47 µM -0.859023393392624 0.208840313215324 no 2690 0.195163804877658 3881 41905075
SGTC_1708 st033234 31.827 µM -0.859347816445054 0.208754073308614 no 2691 0.195074325346654 4006 674664
SGTC_1619 st003326 88.7 µM -0.859832083364767 0.208625381884833 no 2692 0.194940805482095 3897 2849032
SGTC_620 0109-0052 432 µM -0.860483831392878 0.208452257070389 no 2693 0.194761196236447 3894 493037
SGTC_2255 7941087 197.44 µM -0.860898578790187 0.208342131217697 no 2694 0.194646952244282 3977 935561
SGTC_54 0159-0055 9 µM -0.861471617687106 0.208190031474686 no 2695 0.19448917326729 3889 3319099
SGTC_2825 7998094 58.44 µM -0.862031952721144 0.208041367053861 no 2696 0.194334967436485 3925 2987815
SGTC_3082 9117008 49.47 µM -0.865149335720649 0.207215428226825 no 2697 0.193478414509725 3989 41448529
SGTC_645 0845-0943 5.41 µM -0.865449147644188 0.207136096546142 no 2698 0.193396157761338 3924 1885106
SGTC_2669 eugenol 100 µM -0.86593791170089 0.207006805744875 no 2699 0.193262105639663 3907 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2523 spermine 47.74 µM -0.866157295488908 0.206948788559209 no 2700 0.193201954229082 3933 1103 A DNA binding polyamine.
SGTC_1804 st050076 49.1 µM -0.86666298245806 0.206815093664954 no 2701 0.193063346751031 3957 3895976
SGTC_548 1436-0017 110 µM -0.868731395374809 0.206268773559898 no 2702 0.19249703252024 4003 9677137
SGTC_2804 7954240 19.48 µM -0.869128607556178 0.206163957778391 no 2703 0.192388395483089 3975 828705
SGTC_2318 6029776 164 µM -0.873327640658846 0.205057855538743 no 2704 0.191242259405279 3929 818325
SGTC_2315 7733312 200 µM -0.873362048380585 0.205048806508877 no 2705 0.191232885058745 3873 726316
SGTC_547 1120-0019 610 nM -0.874431119946426 0.204767765203467 no 2706 0.190941758031709 3868 3676939
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.875183316157796 0.204570162586691 no 2707 0.190737084775346 3929 3256 An antibiotic and ribosome inhibitor.
SGTC_694 1315-0438 43.2 µM -0.87549799697977 0.204487529328463 no 2708 0.190651499804383 3900 6793154
SGTC_461 N-acetylfarnesylcysteine 136 µM -0.875680075089583 0.204439725804813 no 2709 0.190601990077336 3976 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.875846755214568 0.204395970762544 no 2710 0.19055667421001 3986 4174840
SGTC_2221 6807166 181.081 µM -0.875940502573339 0.204371363681452 no 2711 0.190531189717419 3857 674925
SGTC_2997 9067075 71.4286 µM -0.875988774017412 0.204358693939391 no 2712 0.190518068315796 3962 27209819
SGTC_3230 9131665 49.47 µM -0.878439681351475 0.203716022308717 no 2713 0.18985257899961 3860 15943720
SGTC_1987 st072290 61.9 µM -0.879527384070508 0.203431193721319 no 2714 0.189557696024204 3966 54697379
SGTC_180 1486-1293 102.781 µM -0.881967938985927 0.202792969052148 no 2715 0.188897072642967 3855 4140536
SGTC_2055 5235184 200 µM -0.88477362404048 0.202060739988851 no 2716 0.188139368921623 4016 2836034
SGTC_1626 st003712 1.76 µM -0.886140602833439 0.201704559169331 no 2717 0.187770882956959 3971 24207035
SGTC_2397 5161689 200 µM -0.886720902521568 0.201553469703289 no 2718 0.187614590902974 3984 2259942
SGTC_672 1441-0018 53.7 µM -0.886793316409013 0.201534620454064 no 2719 0.187595093320588 3942 251141
SGTC_2620 irigenin 100 µM -0.887205478299951 0.201427355316958 no 2720 0.187484141760421 4007 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1414 3917-0015 5.4 µM -0.88723798047463 0.201418898081298 no 2721 0.187475394091389 3895 6618702
SGTC_2015 5119600 184 µM -0.887944800672903 0.201235032413797 no 2722 0.187285222164536 3998 2828786
SGTC_546 peri-Naphthalide 147 µM -0.888541875176601 0.201079793412058 no 2723 0.187124670586023 3865 223824 A penicillin ester.
SGTC_2533 agelasine 13.65 µM -0.889405096530689 0.200855483425222 no 2724 0.186892703455481 4026 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_710 3448-4187 58 µM -0.891245478356844 0.200377757716431 no 2725 0.186398745589459 3938 3946412
SGTC_658 3253-0951 102 µM -0.891361938396462 0.200347550038758 no 2726 0.1863675149851 3962 1184878
SGTC_2038 4100038 30.985 µM -0.891785048669883 0.200237825733405 no 2727 0.186254078547737 3967 3596803
SGTC_1606 st000094 49.2 µM -0.893363351003026 0.199828846573897 no 2728 0.185831311137487 3951 1242210
SGTC_327 1273-0057 3.96 µM -0.895360907118862 0.199311948824838 no 2729 0.185297095595151 3850 3108138
SGTC_3048 9093155 49.47 µM -0.896580880556192 0.198996658706458 no 2730 0.184971302045307 3887 25236002
SGTC_822 1487-0950 154 µM -0.898727331839297 0.198442659623897 no 2731 0.184398957493252 3986 1958375
SGTC_415 dibenzyl ketone 100 µM -0.899439898830279 0.198258952013562 no 2732 0.18420919756851 3980 7593
SGTC_3149 9097855 49.47 µM -0.900195166676176 0.198064347756995 no 2733 0.184008198933858 3983 25236625 YMR079W SEC14
SGTC_3301 9125354 19.7965 µM -0.901833205803025 0.19764268293527 no 2734 0.183572738772161 3943 41905162
SGTC_1148 3909-7663 27.7 µM -0.902770474485812 0.19740165502084 no 2735 0.183323862184014 4013 4084526
SGTC_902 1120-0002 2.07 µM -0.903736768035851 0.197153349265058 no 2736 0.183067498884406 3950 3280475
SGTC_1472 k841-0093 193 µM -0.904833297128107 0.196871806275958 no 2737 0.182776854391336 4075 X1472
SGTC_2747 doxorubicin 7.63 µM -0.909357413836689 0.195712777976988 no 2738 0.181580746718059 3901 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1115 galangin 695.678 nM -0.911286447177342 0.195219843307629 no 2739 0.181072232727595 4013 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_150 3970-0969 77.2 µM -0.911819646124518 0.195083725758291 no 2740 0.180931833273956 4072 6615640
SGTC_2026 5148700 152 µM -0.912959897986406 0.194792830539086 no 2741 0.180631816508451 3949 79838
SGTC_1306 1185-0270 9.02 µM -0.91394822625006 0.194540906864064 no 2742 0.180372025578626 4018 1548076
SGTC_1200 1643-0193 18.4 µM -0.916716699808393 0.193836282672176 no 2743 0.179645556411812 3982 5403974
SGTC_199 4063-0024 41.6 µM -0.918381112590588 0.193413410707456 no 2744 0.179209687687165 4010 306215
SGTC_761 k216-0224 480 µM -0.918691671055496 0.193334570477302 no 2745 0.179128433765146 3982 1340404
SGTC_2074 5212007 75.395 µM -0.919672444384818 0.193085714279478 no 2746 0.17887197830497 3841 758611
SGTC_1337 1486-1011 40.3 µM -0.920510396625335 0.192873251745809 no 2747 0.17865305127936 3980 X1337
SGTC_663 1486-0733 13.9 µM -0.921239562486795 0.192688488211011 no 2748 0.178462683606085 3991 722445 YPR165W RHO1
SGTC_350 k064-0020 19.8 µM -0.922676152527598 0.19232478686863 no 2749 0.178087998533938 4007 2790705
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.925499955809659 0.191611109620377 no 2750 0.177352953337409 4014 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_37 0566-0070 1.56 µM -0.926736222192214 0.19129917159339 no 2751 0.177031752934965 3982 1626686
SGTC_1820 st053765 18.6 µM -0.928887538346006 0.19075708841091 no 2752 0.176473685896516 4067 3690829
SGTC_1155 4088-0394 48.2 µM -0.931904945924609 0.189998359839854 no 2753 0.175692825678063 3990 2326248
SGTC_3076 9116187 49.47 µM -0.932877026294841 0.189754325364998 no 2754 0.175441732656923 4006 27241210
SGTC_1678 st019265 80.2 µM -0.933260278443982 0.189658165402632 no 2755 0.175342799342013 4040 5367020
SGTC_2297 7971671 152.32 µM -0.934336559154375 0.189388281289342 no 2756 0.175065155733605 4032 909016
SGTC_2124 5246320 200 µM -0.934928587710589 0.18923992725281 no 2757 0.174912551583896 4029 579342
SGTC_2093 5331342 194.4 µM -0.937267608544619 0.188654501561817 no 2758 0.174310460167827 4100 33839
SGTC_505 gw-5074 63.9 µM -0.937750143900049 0.188533868466703 no 2759 0.174186413950974 4066 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_402 epigallocatechin gallate 10 µM -0.939037789850518 0.188212191850828 no 2760 0.17385567121988 3957 65064 An antioxidant.
SGTC_1456 k015-0012 13 µM -0.940088842137974 0.187949871697066 no 2761 0.173585995831927 4006 2989616
SGTC_2765 myclobutanil 7.74 µM -0.942158557792766 0.187433975270533 no 2762 0.1730557339247 4064 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_1252 0493-0875 34.8 µM -0.942490492379703 0.187351318915416 no 2763 0.172970788275296 4011 3960963
SGTC_886 0866-0150 153 µM -0.943587173586709 0.187078390201647 no 2764 0.17269032461741 4088 271463
SGTC_770 0389-1121 67.2 µM -0.944313153721037 0.186897852434162 no 2765 0.172504823081856 4142 6753108
SGTC_1651 st011928 86.1 µM -0.945503611009413 0.186602041265228 no 2766 0.172200914079216 4042 720198
SGTC_699 0375-0592 111 µM -0.946356481970184 0.186390293692134 no 2767 0.171983396886084 4106 762578
SGTC_2505 galangin 7.89 µM -0.947290639617445 0.186158535446931 no 2768 0.171745349621035 3916 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_968 1309-0633 340 µM -0.949029201741248 0.185727685607855 no 2769 0.171302880127267 4076 3761976
SGTC_3338 9144300 39.5675 µM -0.949101158227087 0.185709866718849 no 2770 0.171284582696005 4043 4901274
SGTC_246 cycloheximide 667 µM -0.950409622310831 0.185386031232324 no 2771 0.17095207829959 3902 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_527 4476-4215 268 µM -0.951484472063004 0.185120276055887 no 2772 0.170679248683274 4015 4418754
SGTC_3016 9080866 49.47 µM -0.951631320213658 0.18508398642773 no 2773 0.170641995801086 4017 17066299
SGTC_2900 5328528 85.29 µM -0.95212651147356 0.184961645613491 no 2774 0.170516412561518 4037 795359
SGTC_1466 k213-0079 57.5 µM -0.952247001494826 0.184931885228242 no 2775 0.170485864580502 3957 3657981
SGTC_3265 9137266 49.47 µM -0.953574782419592 0.184604127598314 no 2776 0.170149462798226 3917 17224265
SGTC_1661 st013063 9.66 µM -0.953628758536695 0.184590811445779 no 2777 0.170135796607243 4078 721395
SGTC_462 ag-879 158 µM -0.954747511517077 0.184314944527052 no 2778 0.169852698389321 4057 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_3125 9127534 49.47 µM -0.954840391150166 0.18429205340626 no 2779 0.169829208969273 3921 1639235
SGTC_1863 st057641 20.1 µM -0.955268545898647 0.184186553232658 no 2780 0.169720954826204 4048 3921635
SGTC_3208 9114115 49.47 µM -0.956084024047498 0.183985718002964 no 2781 0.169514892740462 4063 650895
SGTC_2024 5144227 134 µM -0.956434183587258 0.183899522885733 no 2782 0.169426460677414 4114 3475211
SGTC_2748 diazoxide 86.69 µM -0.956677814932764 0.1838395655401 no 2783 0.169364949556864 4058 3019 A potassium channel activatior.
SGTC_3318 9139014 38.6185 µM -0.957382326207545 0.183666254785818 no 2784 0.169187157877861 4032 16643984
SGTC_2479 5617353 43.85 µM -0.957641409131872 0.183602545636743 no 2785 0.16912180541283 4105 2731746
SGTC_1103 duloxetine 36.1 µM -0.960806474071092 0.182825360225408 no 2786 0.168324741393723 4130 60835 A selective serotonin reuptake inhibitor.
SGTC_2860 9025725 38.96 µM -0.960967610756582 0.182785847933921 no 2787 0.168284226789971 4061 40546248
SGTC_2665 lovastatin 100 µM -0.963979394113999 0.182048310395513 no 2788 0.16752812842708 4068 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_57 miconazole 162.5 nM -0.964304247742726 0.181968870259116 no 2789 0.167446705943267 3964 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1327 1436-0082 2.18 µM -0.964940390797732 0.1818133697927 no 2790 0.167287334623576 4031 15992205
SGTC_2282 7944268 200 µM -0.966536903990348 0.181423480158131 no 2791 0.16688779491031 4079 2970414
SGTC_1213 1315-0166 115 µM -0.967146298828537 0.181274796012385 no 2792 0.16673545161121 4155 768401
SGTC_259 usnic acid 108.925 µM -0.968129058774509 0.181035176614969 no 2793 0.166489959451598 4142 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1339 1486-1321 22.7 µM -0.968138872152747 0.181032784889634 no 2794 0.166487509259668 4063 3469382
SGTC_3226 9131256 49.47 µM -0.968402880324845 0.180968448012435 no 2795 0.16642160076871 3971 17178073
SGTC_1561 5-methoxyflavone 52.9 µM -0.970523803065342 0.180452114541854 no 2796 0.165892733020087 3965 94525
SGTC_3336 9143619 71.43 µM -0.970844420246771 0.180374141559993 no 2797 0.16581287937886 4091 45595730
SGTC_2309 7664088 163.95 µM -0.972419549876605 0.179991382621239 no 2798 0.165420934993225 4080 704922
SGTC_1126 isoteolin 1.0172 µM -0.973682525666951 0.179684846257929 no 2799 0.165107098146014 3997 133323
SGTC_3177 9107506 49.47 µM -0.974805229697778 0.179412630768394 no 2800 0.164828441248989 4015 8897194
SGTC_163 TUB2.036 7.546 µM -0.97633742851796 0.17904154607768 no 2801 0.164448638941821 4046 15992207 YJR013W GPI14
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.977621233604288 0.178730992208093 no 2802 0.164130845751023 4048 66535 A nucleotide analog.
SGTC_2741 miltefosine 3.04 µM -0.977702954118338 0.17871123541305 no 2803 0.164110630143773 4036 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_138 0850-0259 40.9225 µM -0.978114849594469 0.178611676275413 no 2804 0.164008762111458 4031 6813004
SGTC_2520 obtusaquinone 4.71 µM -0.978681939304568 0.178474662343778 no 2805 0.163868579313983 4116 5967872
SGTC_1341 1486-1360 280 µM -0.979374689668036 0.178307377542954 no 2806 0.163697439139573 4044 3976547
SGTC_1251 0490-5699 265 µM -0.982391270770041 0.177580088365607 no 2807 0.162953562565772 4126 3883818
SGTC_2921 7974240 10.71 µM -0.987098554918061 0.176448921537957 no 2808 0.161797163070299 4165 2979074 YDR527W RBA50
SGTC_1668 st014914 51.6 µM -0.987954146483612 0.176243812297011 no 2809 0.161587552697745 4085 2839556
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.988250106281231 0.176172897589721 no 2810 0.161515087081775 4056 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_2908 7930301 100 µM -0.988304801563066 0.17615979407137 no 2811 0.161501697288053 4055 2223178
SGTC_3157 9099274 49.47 µM -0.988315106219869 0.176157325421834 no 2812 0.161499174715856 4102 17217662
SGTC_2524 avocatin b 10.57 µM -0.989314979137349 0.175917893616014 no 2813 0.161254528766686 4040 6710748
SGTC_1739 st037196 92.5 µM -0.98998498704634 0.175757567398561 no 2814 0.16109072855911 4171 612214
SGTC_1795 st049545 62.3 µM -0.990376436861343 0.175663940209285 no 2815 0.160995079116711 4001 5291882
SGTC_2096 5468907 200 µM -0.991176351766679 0.175472714397905 no 2816 0.16079973789423 4109 759785
SGTC_523 1934-0222 13.7 µM -0.996146349687835 0.174287556597268 no 2817 0.159589521192813 4044 1361595
SGTC_2127 5253358 187.912 µM -0.997630290014292 0.173934680918761 no 2818 0.15922933376934 3994 20612
SGTC_3321 9137793 26.8275 µM -0.997724215065611 0.173912361176909 no 2819 0.159206553867373 4061 4904192
SGTC_3346 9158254 43.5805 µM -0.998312046654416 0.173772714050615 no 2820 0.159064033935139 4088 17639500
SGTC_3105 9121040 49.47 µM -0.998725049166859 0.173674642543918 no 2821 0.158963951369886 3952 41448907
SGTC_61 0978-8327 98.565 µM -0.9988827951686 0.173637193500248 no 2822 0.158925735801389 4009 6150059 YHR072W ERG7
SGTC_2262 9014885 67.46 µM -0.999080713643035 0.173590214742852 no 2823 0.158877796560484 4046 6457424
SGTC_1300 1094-0077 113 µM -0.999563981075826 0.173475538351276 no 2824 0.158760780747273 4064 5532636
SGTC_2708 st078559 56 µM -1.00003642539304 0.173363476839227 no 2825 0.158646440213237 4026 17250902
SGTC_3018 9082602 49.47 µM -1.00282223440447 0.172703633728457 no 2826 0.157973319475828 4055 17332089
SGTC_13 0199-0087 65 µM -1.00318071277627 0.17261884142002 no 2827 0.157886838555329 4149 4589825
SGTC_2797 7859098 81.82 µM -1.00585424299812 0.171987298118836 no 2828 0.157242844917859 4085 972681
SGTC_819 1013-0258 27.7 µM -1.00729427612831 0.171647744443623 no 2829 0.156896689798198 4115 5753198
SGTC_293 4049-0273 38.5 µM -1.00761314663471 0.17157261409326 no 2830 0.156820107568551 3962 1380311
SGTC_2796 7949634 45.45 µM -1.00800997640413 0.171479144800455 no 2831 0.156724836441904 4058 2971588
SGTC_940 3232-1287 54.8 µM -1.00884027340888 0.17128368192305 no 2832 0.156525621505389 4028 1585493 YIL048W NEO1
SGTC_1451 4152-0210 104 µM -1.00898461444199 0.171249716677586 no 2833 0.156491006471537 4143 659563
SGTC_2257 7960413 200 µM -1.01153062738445 0.170651316077532 no 2834 0.15588126496681 4107 2974689 YIL048W NEO1
SGTC_1882 5615643 20 µM -1.01308104017034 0.170287572313166 no 2835 0.155510726817452 4062 2253075
SGTC_2745 rifampicin 24.3 µM -1.01427008860174 0.170008945358829 no 2836 0.155226946325897 4128 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2089 5281248 129.67 µM -1.01444776122541 0.169967336855017 no 2837 0.155184572022922 4085 2737878
SGTC_211 3455-0679 143.504 µM -1.01540773749938 0.169742636446786 no 2838 0.154955753121026 4154 748649
SGTC_212 3807-4682 38.772 µM -1.01595134273126 0.169615479997193 no 2839 0.154826278833459 4171 3125501 YBL034C STU1
SGTC_2246 7293507 91.5585 µM -1.01609468995379 0.169581959370879 no 2840 0.154792148726437 4152 887656
SGTC_777 1315-0167 517 µM -1.0169356768869 0.169385386772131 no 2841 0.154592014948776 4122 4221767
SGTC_2375 9072683 200 µM -1.0170920330304 0.169348856157344 no 2842 0.154554824973147 4173 16798029
SGTC_3064 1327-0027 10 µM -1.01775727407161 0.169193487620797 no 2843 0.154396660660269 4010 16000455 YPR107C YTH1
SGTC_2367 9070478 135.38 µM -1.01860891222447 0.168994719242628 no 2844 0.154194335765409 4068 572802
SGTC_1326 1431-2094 10.8 µM -1.01919959978699 0.16885694364531 no 2845 0.154054108315783 4089 616278
SGTC_355 1311-2252 105 µM -1.01961628403929 0.168759797071803 no 2846 0.153955239494166 4099 5338538
SGTC_740 k014-0057 261 µM -1.01983025865762 0.168709924574966 no 2847 0.15390448495306 4106 4012779
SGTC_661 1304-0007 33.6 µM -1.02287625296093 0.168001001627665 no 2848 0.153183179348084 4115 3117130
SGTC_3223 9129970 49.47 µM -1.02608748694477 0.167255700076996 no 2849 0.152425173956855 4140 17248386
SGTC_878 0828-0289 13.7 µM -1.02699981070556 0.167044346421137 no 2850 0.152210276608385 4068 745350 YLR208W SEC13
SGTC_1191 1487-1166 10.6 µM -1.02778183228971 0.166863316388219 no 2851 0.152026232056237 4158 3955771
SGTC_2426 5582046 32.21 µM -1.03166859195888 0.165965449556195 no 2852 0.151113697825325 4137 2251934
SGTC_2311 7694451 200 µM -1.03360531898185 0.165519220642624 no 2853 0.150660355891297 4113 2163142
SGTC_3096 9117468 49.47 µM -1.03601267880106 0.164965639083326 no 2854 0.150098113776102 4012 41316311
SGTC_807 1315-0151 48 µM -1.0395983927424 0.164143315927999 no 2855 0.149263261976951 4165 4011080
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -1.04175133530571 0.163650854405325 no 2856 0.148763490865748 4097 6708514
SGTC_2891 9063876 19.48 µM -1.04243725304601 0.163494160091753 no 2857 0.14860450124561 4129 6472478
SGTC_2518 prenyletin 46.28 µM -1.04685326242483 0.162487679786267 no 2858 0.147583630314998 4097 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_1343 1487-0095 224 µM -1.04826094684514 0.162167694912223 no 2859 0.14725919865618 4155 4560101 YGL055W OLE1
SGTC_1411 3909-8223 150 µM -1.04928558029845 0.161935040683087 no 2860 0.147023350306339 4165 X1411
SGTC_1378 2093-0007 380 nM -1.05051313885067 0.161656596535074 no 2861 0.146741126696472 4217 3618014
SGTC_124 0136-0217 7.121 µM -1.05202718494282 0.161313599188058 no 2862 0.146393538693925 4191 3976905
SGTC_793 0488-0545 106 µM -1.05358669550043 0.160960798807163 no 2863 0.146036091530361 4171 292548
SGTC_1233 0325-0408 14.2 µM -1.05358951413491 0.160960161617674 no 2864 0.146035446017367 4187 12874
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.05453659789534 0.160746154064434 no 2865 0.145818657014093 4177 5282362
SGTC_1183 1254-0324 198 µM -1.05499463752741 0.160642719938559 no 2866 0.145713888642674 4230 5799357
SGTC_295 k015-0027 31 µM -1.0555251488814 0.160522974651066 no 2867 0.145592606922259 4181 3887424
SGTC_1528 arabinosylhypoxanthine 74.6 µM -1.05706355079657 0.160176061408798 no 2868 0.145241292349551 4227 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2700 st077718 96.8 µM -1.05712075985846 0.160163170090013 no 2869 0.145228238907406 4141 904970
SGTC_2532 xanthone 78.9 µM -1.05772307216038 0.160027488001345 no 2870 0.145090856683161 4149 7020 An insecticide.
SGTC_1069 diphenylcyclopropenone 8.49 µM -1.05854560651585 0.159842318229191 no 2871 0.144903385043007 4178 65057 A dermal irritant. YDR527W RBA50
SGTC_3017 9080681 49.47 µM -1.05872700519419 0.159801500445019 no 2872 0.144862062701732 4164 16451914
SGTC_262 fenpropimorph 62.5 µM -1.05939743810145 0.159650700831091 no 2873 0.144709407971157 4123 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2252 omeprazole 400 µM -1.05954056099274 0.159618520448589 no 2874 0.144676833534561 4118 4594 A proton pump inhibitor.
SGTC_1254 0550-0035 264 µM -1.06033450874431 0.159440082827643 no 2875 0.144496222572682 4205 15121435
SGTC_1550 gossypolone 36.6 µM -1.06080396706292 0.159334634795455 no 2876 0.144389499493977 4172 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1629 st005085 44.9 µM -1.06186888992128 0.15909560499268 no 2877 0.144147605011656 4103 24207091
SGTC_1737 st035557 69.7 µM -1.06254083959659 0.158944901864819 no 2878 0.14399511404921 4021 5716916
SGTC_654 1124-0271 80.9 µM -1.06453158053994 0.158498972951064 no 2879 0.143543977963949 4139 5403748
SGTC_842 0271-0008 11.1 µM -1.06590892931882 0.158190925514468 no 2880 0.143232406061745 4206 1221709
SGTC_2324 6149169 200 µM -1.06745517663739 0.157845571956103 no 2881 0.142883171997355 4068 2888231
SGTC_1855 st056195 39.6 µM -1.06751981037898 0.157831146831728 no 2882 0.142868586418622 4116 4028379
SGTC_3049 9092223 49.47 µM -1.06886654973917 0.157530775049028 no 2883 0.142564903294275 4145 8623917
SGTC_1923 st058458 19.1 µM -1.07016969114581 0.157240485024563 no 2884 0.14227146714475 4177 3534982
SGTC_2233 sulbentine 40.3845 µM -1.07022260346897 0.157228705619477 no 2885 0.142259561200005 4155 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_3014 9081533 49.47 µM -1.07046352161332 0.157175079467484 no 2886 0.142205360080833 4201 21367265
SGTC_644 1498-1197 63.3 µM -1.07055470370175 0.1571547863153 no 2887 0.142184849824588 4193 6741615
SGTC_595 3909-8003 73.7 µM -1.07393460393531 0.15640378374878 no 2888 0.141425996348158 4236 699517
SGTC_1362 1611-0397 101 µM -1.07520994533136 0.156121022326117 no 2889 0.141140371887337 4134 27816
SGTC_2805 7950783 58.44 µM -1.0814874914135 0.15473411317339 no 2890 0.139740160931759 4200 1178958 YDL195W SEC31
SGTC_1891 st059073 26.2 µM -1.08325412753705 0.154345279505198 no 2891 0.13934782018009 4256 688754
SGTC_2474 5321570 43.32 µM -1.08443218936677 0.154086349428901 no 2892 0.13908660896567 4174 2841384
SGTC_1001 4048-4355 44.4 µM -1.08443808681985 0.154085053931636 no 2893 0.139085302164549 4155 21824233
SGTC_2335 9018011 154.17 µM -1.08464353734544 0.15403992698207 no 2894 0.139039782139771 4175 6458208
SGTC_3029 9088683 49.47 µM -1.08556356800422 0.15383795066715 no 2895 0.138836062729485 4217 25236615
SGTC_1109 tnp00067 928.257 nM -1.0861954672505 0.153699330044729 no 2896 0.138696261130504 4172 676295
SGTC_164 4100-3994 89.624 µM -1.08824711885666 0.153249826642606 no 2897 0.138243014308519 4131 4615967
SGTC_1500 4488-1866 171 µM -1.08842847877094 0.153210133821887 no 2898 0.138202997266317 4240 2900003
SGTC_2926 9010726 65.15 µM -1.0897820397091 0.152914105745834 no 2899 0.13790458365583 4221 2994293
SGTC_1409 3909-8004 61.9 µM -1.09405333326467 0.151982448408215 no 2900 0.136965793951859 4207 2119279
SGTC_567 1080-0542 68.4 µM -1.09624680452427 0.151505475385947 no 2901 0.136485390974405 4051 5950415
SGTC_683 panaxydol 45 µM -1.09711321110938 0.151317348694107 no 2902 0.136295952888146 4172 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2366 9070441 60.58 µM -1.09836457803298 0.151045908223703 no 2903 0.136022661683177 4177 6837235
SGTC_3324 9138759 60.749 µM -1.09905345311738 0.150896619133743 no 2904 0.135872375603558 4244 45595710
SGTC_3071 9117417 49.47 µM -1.10075165025602 0.150529015131316 no 2905 0.135502379993439 4149 45595590 YGL055W OLE1
SGTC_2987 9018338 71.43 µM -1.10160255763502 0.150345046097483 no 2906 0.135317247962571 4222 5055682
SGTC_3193 9111931 49.47 µM -1.10164661245697 0.150335525377835 no 2907 0.135307667672069 4209 17087244
SGTC_1677 st019204 53.9 µM -1.1017596967118 0.150311088496391 no 2908 0.135283078167575 4232 3945625
SGTC_2129 girgensonine 121.053 µM -1.10208557766525 0.150240682232069 no 2909 0.135212234409634 4200 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_109 0132-0036 33.701 µM -1.10446120588478 0.149728094254339 no 2910 0.134696561522728 4000 67274 A color developer.
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.10532453162404 0.149542104313213 no 2911 0.134509495911462 4252 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2342 7990637 118.86 µM -1.10705843003157 0.149169029168264 no 2912 0.134134333411327 4241 2033102 YER133W GLC7
SGTC_1291 0993-0025 5.79 µM -1.10759263801088 0.149054211396187 no 2913 0.134018892156099 4197 4353356
SGTC_3168 9103419 49.47 µM -1.11407073099886 0.147666568441044 no 2914 0.132624421988034 4208 16649256
SGTC_3106 9121286 49.47 µM -1.11463620445826 0.147545852859343 no 2915 0.132503174597773 4191 15943471
SGTC_662 k832-1615 104 µM -1.11531063389814 0.147401964147413 no 2916 0.132358665037295 4235 5878478
SGTC_838 0109-0203 71.4 µM -1.11682885465817 0.147078397755458 no 2917 0.132033754449846 4225 759422
SGTC_307 1501-1223 22.3 µM -1.11870722989958 0.146678734058759 no 2918 0.13163252989643 4247 2830329
SGTC_2269 7935389 174.42 µM -1.12083049057641 0.146227844078337 no 2919 0.131180011414891 4188 97605
SGTC_2105 5350118 200 µM -1.12144235674307 0.146098082765713 no 2920 0.131049807524786 4189 2133313
SGTC_1752 st044819 83.042 µM -1.1223086110661 0.145914504484672 no 2921 0.1308656230722 4191 441209 YML126C ERG13
SGTC_2463 5473429 200 µM -1.12343666726813 0.145675677101795 no 2922 0.130626042146523 4197 5399405
SGTC_3289 9119912 71.43 µM -1.12632678394736 0.145064993327341 no 2923 0.130013612382678 4257 17014829
SGTC_373 0844-0104 25.9 µM -1.12813409275462 0.144683984555123 no 2924 0.129631646442022 4239 5375804
SGTC_2899 9053889 58.44 µM -1.1303094330078 0.14422628368973 no 2925 0.129172930573437 4198 6470052
SGTC_1403 3909-7815 62.9 µM -1.13206721598267 0.143857152441701 no 2926 0.128803088305947 4176 6615483
SGTC_2215 7188065 200 µM -1.13268644903784 0.143727266561167 no 2927 0.12867297514633 4258 940217
SGTC_1835 st008666 49.2 µM -1.13452273848682 0.1433425650473 no 2928 0.128287670608078 4154 690455
SGTC_1607 st000305 50.6 µM -1.13741974085658 0.142737059784974 no 2929 0.127681429330015 4244 5457690
SGTC_2263 7948595 193.29 µM -1.13749203503099 0.142721971656305 no 2930 0.12766632619908 4231 2971371
SGTC_1632 st005650 90 µM -1.1392337840485 0.142358786489079 no 2931 0.127302829027047 4252 2759605
SGTC_194 1486-1323 56.904 µM -1.14241640616051 0.141696770313112 no 2932 0.126640487486775 4313 5178754
SGTC_2581 avocatin a 64 µM -1.14805349994213 0.140529325225415 no 2933 0.125473239329443 4203 6710728 A skin care supplement.
SGTC_2436 5633522 8.09 µM -1.14809535705232 0.140520681089018 no 2934 0.125464600339255 4237 5724242
SGTC_1280 0880-0253 10.1 µM -1.14963440895565 0.14020309384766 no 2935 0.125147239919993 4222 6836607
SGTC_2758 dehydroepiandrosterone 69.35 µM -1.15009969093424 0.140107177790446 no 2936 0.125051406834943 4253 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_3277 9138724 49.47 µM -1.15081015620045 0.13996080418363 no 2937 0.124905172807224 4203 15943418
SGTC_1170 0310-0127 64.8 µM -1.15082740464097 0.139957251866228 no 2938 0.124901624071988 4237 774975
SGTC_3210 9128157 49.47 µM -1.15146309655172 0.139826373817389 no 2939 0.124770884439494 4243 17590849
SGTC_440 fluspirilene 35.1 µM -1.15533284462667 0.139031454027233 no 2940 0.123977075405788 4321 3396 An atypical antipsychotic.
SGTC_1383 3049-0032 20.7 µM -1.15792401988795 0.138500900277142 no 2941 0.123447522160982 4305 712864
SGTC_1911 st060208 74.3 µM -1.15904202533527 0.138272410682001 no 2942 0.123219527650039 4286 688783
SGTC_3050 9093513 49.47 µM -1.16014657480634 0.138046923599836 no 2943 0.122994567151159 4217 25236664
SGTC_977 1348-1378 135 µM -1.16260438409015 0.137546076990684 no 2944 0.12249502561526 4239 X977
SGTC_2349 9023730 187.07 µM -1.16401220519044 0.137259753928428 no 2945 0.122209532797813 4272 4126287
SGTC_2097 5376186 200 µM -1.16474295552424 0.137111294317322 no 2946 0.122061527841668 4238 742755
SGTC_1194 1488-0194 225 µM -1.16690753401982 0.136672181360303 no 2947 0.121623856521784 4206 1391452
SGTC_1954 st077032 68.9 µM -1.16740341927175 0.136571720097916 no 2948 0.121523745471744 4216 698907
SGTC_1570 verbenone 133 µM -1.16900472631794 0.136247656618869 no 2949 0.121200863576641 4277 29025 A natural terpanoid with antifungal properties.
SGTC_1336 1486-0901 104 µM -1.16923781785682 0.136200528776302 no 2950 0.121153914175967 4274 5006114
SGTC_964 1287-0107 19.4 µM -1.17063348857214 0.135918577102502 no 2951 0.120873065175895 4280 51516812 YPR165W RHO1
SGTC_356 1634-0012 32.5 µM -1.17147187684065 0.135749399210002 no 2952 0.120704577837216 4269 735457
SGTC_1040 k898-0338 155 µM -1.17215876555258 0.135610899857643 no 2953 0.12056665999131 4257 20969351
SGTC_2953 9074162 66.49 µM -1.172360727497 0.135570196110844 no 2954 0.120526129916093 4259 16451992
SGTC_1243 0416-0003 5.65 µM -1.17548938856523 0.134940709683363 no 2955 0.119899490038105 4257 2141977
SGTC_2768 sulfasalazine 50.2 µM -1.17551837188713 0.134934887628667 no 2956 0.119893695722677 4253 5384001 An antioxidant and salicylic acid derivative.
SGTC_1072 oxiconazole 14.9 nM -1.17865313346286 0.134306206117718 no 2957 0.119268162408946 4249 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1313 1220-0047 237 µM -1.18078819589367 0.133879169237127 no 2958 0.118843437245838 4241 3528706
SGTC_2812 7970281 58.44 µM -1.18468121626603 0.133102924870962 no 2959 0.118071755972151 4313 2233435
SGTC_3107 9121808 49.47 µM -1.18486772220017 0.13306581464938 no 2960 0.118034875608725 4212 662681
SGTC_1828 st055811 49 µM -1.185302102325 0.132979411001535 no 2961 0.117949011290118 4277 5877589
SGTC_1061 3448-9325 110 µM -1.18553901707694 0.132932301970846 no 2962 0.117902198760403 4230 723482
SGTC_2711 st079103 59.1 µM -1.18670810882919 0.132700003570623 no 2963 0.117671387716766 4223 54693780
SGTC_1104 tacrolimus 29.8 µM -1.1880064290401 0.132442355335976 no 2964 0.117415438407039 4330 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2886 9058944 51.95 µM -1.18962559067631 0.132121520273363 no 2965 0.117096791522372 4151 4949929
SGTC_328 k915-0120 63.5 µM -1.19000759447064 0.132045904845266 no 2966 0.117021703560694 4266 6624543
SGTC_3127 9126946 49.47 µM -1.19142526019745 0.131765547077579 no 2967 0.11674334066566 4256 27243249
SGTC_3251 9135047 49.47 µM -1.19172153137469 0.13170700837108 no 2968 0.116685226289944 4303 17682963
SGTC_72 0744-0168 198.391 µM -1.1917263128885 0.131706063763395 no 2969 0.116684288551575 4167 677577
SGTC_2630 antimycin a 100 µM -1.19207175785346 0.131637832060931 no 2970 0.116616554898126 4217 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2177 5811945 192 µM -1.19208836735503 0.131634551995179 no 2971 0.116613298867206 4317 5343475
SGTC_3086 9117350 49.47 µM -1.19340522742241 0.131374676270813 no 2972 0.116355354358036 4209 2679265
SGTC_272 doxorubicin 8.13 µM -1.1946135763352 0.13113652652897 no 2973 0.116119021213577 4284 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1644 st010134 20.9 µM -1.19478217080267 0.131103322489032 no 2974 0.116086074016439 4262 3818134
SGTC_359 0081-0058 15.9 µM -1.195335362565 0.130994414267186 no 2975 0.115978014359564 4365 3494159
SGTC_2744 captopril 92.04 µM -1.19557056616515 0.130948128100481 no 2976 0.115932091680356 4342 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_2469 5655019 90.81 µM -1.20039767616882 0.130000687327953 no 2977 0.114992465480316 4338 2788239
SGTC_1352 1496-0991 99 µM -1.20273042937172 0.12954453102672 no 2978 0.114540327245604 4276 3000039
SGTC_1612 st002233 45.4 µM -1.20528983250997 0.129045331693908 no 2979 0.11404571666209 4292 1035021
SGTC_338 4055-0136 114 µM -1.20555728963423 0.128993242544508 no 2980 0.113994117896078 4273 2900563
SGTC_3246 9135460 32.98 µM -1.21177230053096 0.127786930296276 no 2981 0.112799777105667 4272 41446951
SGTC_2176 5809774 33.9695 µM -1.21179492202958 0.127782553909901 no 2982 0.11279544630504 4228 2870539
SGTC_69 0096-0274 206.684 µM -1.21296028370788 0.127557242324543 no 2983 0.112572502768794 4413 6741392
SGTC_2601 securinine 100 µM -1.2162771570142 0.126917468934599 no 2984 0.11193968011842 4279 442872 A GABA receptor antagonist.
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -1.21651703081129 0.126871287765109 no 2985 0.111894013688063 4274 756377
SGTC_1227 3909-8010 46.6 µM -1.21671788373119 0.126832628002713 no 2986 0.111855786180591 4287 15982272
SGTC_668 1682-0499 62.6 µM -1.21796438287139 0.12659288776781 no 2987 0.111618753981328 4276 682214
SGTC_1936 st074407 74.3 µM -1.22000572581489 0.126200956593409 no 2988 0.111231352162589 4329 809813
SGTC_2954 9074818 52.69 µM -1.22124078906534 0.125964239548019 no 2989 0.110997432346039 4328 16648742
SGTC_2876 9059903 25.97 µM -1.22128805755484 0.125955186040373 no 2990 0.110988486744523 4287 6916095
SGTC_2199 6590217 200 µM -1.22141734199628 0.12593042603357 no 2991 0.11096402219264 4196 703109
SGTC_895 0964-0006 13.7 µM -1.22607562375611 0.125040555368626 no 2992 0.11008510900731 4301 6738897
SGTC_1432 4049-0298 68.4 µM -1.22982917849504 0.124326717008216 no 2993 0.109380539621754 4332 741646
SGTC_1948 st076329 66.6 µM -1.23354714834016 0.123622460599625 no 2994 0.108685848750963 4229 24208413
SGTC_1705 st027868 56.3335 µM -1.23780577913665 0.122819230545934 no 2995 0.107894042537615 4251 292948
SGTC_3020 9089140 49.47 µM -1.23849643635924 0.122689309813699 no 2996 0.107766021317114 4333 17217859
SGTC_511 blebbistatin 171 µM -1.24061447550102 0.122291483025519 no 2997 0.107374100936123 4371 3476986 A myosin inhibitor.
SGTC_764 1951-2361 146 µM -1.24062936397266 0.122288689764195 no 2998 0.107371349625767 4322 5438930
SGTC_1223 0764-0573 147 µM -1.24719719061119 0.121060849112786 no 2999 0.106162601391803 4320 1609797
SGTC_3144 9087057 49.47 µM -1.25376637647922 0.119841455918436 no 3000 0.104963466895929 4250 17249618
SGTC_1436 4092-1007 8.32 µM -1.25898224458704 0.118879456611753 no 3001 0.104018372572513 4320 2881121
SGTC_2238 6671620 73.2395 µM -1.25952026022412 0.118780537782439 no 3002 0.103921238497528 4248 729941
SGTC_3011 9081274 71.4286 µM -1.26100714801604 0.118507463027581 no 3003 0.103653135908198 4326 6625322
SGTC_2958 9077254 16.72 µM -1.26697381062174 0.117416117575238 no 3004 0.102582327236432 4391 16457351
SGTC_935 2996-0153 430 µM -1.26709826290201 0.117393430380007 no 3005 0.102560078312176 4338 23738523
SGTC_19 0279-0214 38.434 µM -1.26992505814997 0.116878951786766 no 3006 0.102055663141202 4411 3566274 YBR002C RER2
SGTC_491 tetrandrine 80.3 µM -1.27438947158217 0.116069684248285 no 3007 0.101262710862556 4344 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2707 st078556 66.6 µM -1.2747966763322 0.11599606836474 no 3008 0.101190608713583 4281 17250899
SGTC_3330 9141424 71.43 µM -1.27524604067608 0.115914869202146 no 3009 0.101111084960757 4376 27261020
SGTC_848 0368-0089 85.6 µM -1.27716660772395 0.115568281768618 no 3010 0.100771716632593 4339 762535
SGTC_2448 5185112 27.17 µM -1.27944628021599 0.115157846214155 no 3011 0.100369972664857 4351 5718189
SGTC_543 3844-1095 191 µM -1.27979774651197 0.115094660031506 no 3012 0.100308138314446 4348 4230703
SGTC_337 1315-0038 354 µM -1.28119343792341 0.114843987660164 no 3013 0.100062865223972 4329 1626437
SGTC_3352 9151559 45.5865 µM -1.28206856969139 0.114687008356372 no 3014 0.0999092966905274 4364 17159339
SGTC_2927 9011802 47.9 µM -1.29431143810779 0.112506902774027 no 3015 0.0977789335804311 4351 43912568
SGTC_1554 st069299 38.7 µM -1.29668126341585 0.112088347029268 no 3016 0.0973704393665731 4322 24207999
SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.3001696855651 0.111474253193077 no 3017 0.0967714090163934 4277 6708630 An antioxidant.
SGTC_1079 idarubicin 2.36 µM -1.30392116218461 0.110816542867013 no 3018 0.0961302320238142 4384 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1917 st066507 28.5 µM -1.3054458798038 0.110550024985598 no 3019 0.0958705321860434 4315 3156428
SGTC_2435 5706476 10.6 µM -1.30558507849907 0.110525716213382 no 3020 0.0958468486882734 4360 5725375
SGTC_1769 st044406 64.4 µM -1.30756307071058 0.110180706274904 no 3021 0.0955107747297219 4348 670903
SGTC_90 0870-0863 4.608 µM -1.30908359631185 0.109916015289427 no 3022 0.0952530175682117 4381 1738164
SGTC_2861 9024595 19.48 µM -1.31154041990369 0.10948929970163 no 3023 0.0948376235797896 4294 16482810
SGTC_1822 st052468 42 µM -1.31808754645442 0.108357969080907 no 3024 0.093737171450477 4383 2873678
SGTC_1124 fisetin 1.16336 µM -1.32154479628942 0.107763968151016 no 3025 0.0931598881239697 4385 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_625 k213-0058 121 µM -1.32218133009698 0.107654859460809 no 3026 0.0930538882365677 4455 3655420
SGTC_96 0929-0093 37.281 µM -1.32399862197352 0.107343794281265 no 3027 0.0927517511873659 4390 6991579
SGTC_1054 3429-0080 167 µM -1.32667710744082 0.106886501001825 no 3028 0.0923077584279185 4402 1162877
SGTC_2661 dactinomycin 12.96 µM -1.33196392404087 0.105988020141005 no 3029 0.0914360217441514 4353 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2974 9094440 9.66 µM -1.33670422615436 0.105187069677671 no 3030 0.0906596009488495 4382 25236134
SGTC_700 3453-2283 142 µM -1.33856829169066 0.104873308580595 no 3031 0.0903556271973088 4424 565664
SGTC_3195 9113082 49.47 µM -1.3405749234325 0.104536308573115 no 3032 0.0900292517494374 4394 17018038
SGTC_2473 5854593 8.94 µM -1.34222172146097 0.104260326827093 no 3033 0.0897620577671322 4303 2872951
SGTC_502 l-744,832 89.3 µM -1.34445542482235 0.103886831941255 no 3034 0.0894005807149311 4409 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2451 5856223 45.7 µM -1.3455127653644 0.103710374070919 no 3035 0.0892298508605538 4385 2179896
SGTC_2888 9058547 12.99 µM -1.34967550331751 0.10301777472168 no 3036 0.0885600466952428 4322 16476514
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -1.35374063576577 0.102344663564586 no 3037 0.0879095694689972 4403 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_2116 5511452 16.8835 µM -1.36072555675334 0.10119556867774 no 3038 0.0868002175137136 4421 870744
SGTC_175 3793-3120 23.7 µM -1.36251247363467 0.100903117607866 no 3039 0.0865181051596482 4402 5322297
SGTC_3217 9129673 49.47 µM -1.36376993646061 0.100697687951422 no 3040 0.0863199924933558 4394 17248312
SGTC_610 4215-0184 155 µM -1.36587459524921 0.100354536098942 no 3041 0.0859891639138161 4423 5605015
SGTC_2906 7926292 26.41 µM -1.36716815793959 0.100144052430802 no 3042 0.085786301769346 4426 2966319
SGTC_2955 9076254 12.21 µM -1.38056299650836 0.0979834174837725 no 3043 0.0837066837323549 4341 16459619
SGTC_2848 9016370 25.97 µM -1.38320280226161 0.097561667428512 no 3044 0.0833013453735229 4407 7894410
SGTC_2585 alliin 100 µM -1.38956945633742 0.0965499755745785 no 3045 0.0823298280289223 4478 87310 A garlic compound which reacts with lipids.
SGTC_3314 9135860 59.4275 µM -1.38976519957103 0.0965189936198604 no 3046 0.0823000944326283 4416 25252478
SGTC_1175 0741-0056 27.6 µM -1.38999560404711 0.0964825348934754 no 3047 0.0822651061207535 4496 765927
SGTC_1636 st007707 68.9 µM -1.39113463062983 0.096302446338419 no 3048 0.0820923026146162 4447 403051
SGTC_1162 k048-0130 20.1 µM -1.3923735606908 0.0961068429431215 no 3049 0.0819046532335192 4400 6797406
SGTC_1220 1838-0075 193 µM -1.39997900749133 0.0949124850806874 no 3050 0.0807598024350802 4360 5529645
SGTC_2570 licareol 100 µM -1.40174258140375 0.0946371023244537 no 3051 0.0804960650723159 4393 443158
SGTC_633 0437-0093 97.7 µM -1.40385746901773 0.0943076389597769 no 3052 0.0801806483652166 4366 2831118
SGTC_1263 0774-1208 64.8 µM -1.40890092315626 0.0935253703767821 no 3053 0.0794322332784425 4445 906585
SGTC_2531 methyl deoxycholate 70.07 µM -1.41153670089948 0.0931184577791576 no 3054 0.0790432109349529 4381 16667744 Haematoxylin.
SGTC_2975 9084847 53.72 µM -1.41537855867059 0.0925276956203197 no 3055 0.0784787663749163 4441 27211724
SGTC_2175 5807670 165.306 µM -1.41825561680897 0.0920871096479857 no 3056 0.0780580747615233 4401 241186
SGTC_716 1683-5115 658 µM -1.42020894033905 0.0917888687445685 no 3057 0.0777734308195161 4435 723597
SGTC_1670 st016595 4.04 µM -1.42156841982696 0.0915817209042963 no 3058 0.0775757889998986 4472 597879
SGTC_3119 9125183 49.47 µM -1.42173561976894 0.0915562681053725 no 3059 0.0775515077464669 4301 22695334
SGTC_232 clozapine 119 µM -1.42315874771953 0.0913398379161952 no 3060 0.0773450705840191 4468 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_875 0709-0210 25.7 µM -1.42523035664678 0.0910254645789563 no 3061 0.0770453119992281 4427 6251364
SGTC_1445 4239-0156 97.7 µM -1.42549380973912 0.0909855423156826 no 3062 0.0770072541149914 4483 4008346
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -1.42974047750876 0.0903438161220503 no 3063 0.0763957591063307 4409 279621
SGTC_619 1652-1634 108 µM -1.43014665099149 0.0902826146390401 no 3064 0.0763374666587329 4441 5400454
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -1.43256551782237 0.0899187817674665 no 3065 0.0759910209713143 4446 803109
SGTC_1101 ebselen 5.29 µM -1.43453909407151 0.0896227352323106 no 3066 0.075709240566307 4463 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_893 0958-0369 48.9 µM -1.43478602315415 0.0895857456778097 no 3067 0.0756740409802948 4335 6819948
SGTC_3111 9122088 49.47 µM -1.43572218538059 0.0894456132789835 no 3068 0.0755407048662039 4375 16876704
SGTC_279 1273-0055 2.93 µM -1.43597582673678 0.0894076742570467 no 3069 0.0755046099665592 4497 2847562
SGTC_3202 9113761 49.47 µM -1.43979835437973 0.0888373591165777 no 3070 0.0749622284583318 4387 4798415
SGTC_1315 1237-0019 3.69 µM -1.44019817547606 0.0887778632682907 no 3071 0.0749056696382317 4463 825140
SGTC_1158 4092-0494 91.8 µM -1.44162278232107 0.088566114174682 no 3072 0.0747044089125684 4544 1148199
SGTC_1751 st044839 27.194 µM -1.45140082156084 0.0871228804882522 no 3073 0.0733341405589171 4516 5291326
SGTC_3114 9122766 49.47 µM -1.45361791236277 0.0867980953590176 no 3074 0.0730261339841381 4469 17176985
SGTC_1969 st069479 40.1 µM -1.45404738761661 0.0867352855862357 no 3075 0.0729665843047524 4460 3895485
SGTC_368 fentichlor 4.58 µM -1.46380720237005 0.0853170763688985 no 3076 0.0716233169915491 4478 7329 A pesticide.
SGTC_1132 3456-3614 2.5 µM -1.46725289821275 0.0848205501426037 no 3077 0.071153635860552 4458 3125502
SGTC_1689 st020265 53.493 µM -1.46835382017446 0.0846623644210956 no 3078 0.0710040693128057 4466 5758320 YPR016C TIF6
SGTC_580 1123-0028 41 µM -1.47206967910821 0.084130085655137 no 3079 0.0705010311799831 4525 1677248 YPR107C YTH1
SGTC_233 rapamycin 362 pM -1.47215087380168 0.0841184830199442 no 3080 0.0704900700319039 4474 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_1610 st001799 48.1 µM -1.4739376334524 0.083863460948182 no 3081 0.0702491919447196 4433 621897
SGTC_1410 3909-8106 77.9 µM -1.47596771107656 0.0835744155490712 no 3082 0.0699762802485126 4536 1039210
SGTC_3162 9099653 49.47 µM -1.4829550443352 0.0825852704034388 no 3083 0.0690431776552129 4465 25237511
SGTC_2380 9035439 200 µM -1.48376052367429 0.0824718134901024 no 3084 0.068936231670199 4533 6462575
SGTC_126 0417-1624 672.48 µM -1.49452105702993 0.0809673592849758 no 3085 0.0675197411951972 4537 41912 YDL195W SEC31
SGTC_2540 epiandrosterone 100 µM -1.49491589619046 0.0809125525865159 no 3086 0.0674681965511894 4524 441302 A steroid.
SGTC_2000 st075254 36.4 µM -1.4972810666096 0.0805848350140692 no 3087 0.0671600696300954 4373 17234175
SGTC_941 3237-0776 460 µM -1.49841734335246 0.080427749696319 no 3088 0.0670124265714962 4512 760008
SGTC_3007 9078383 71.4286 µM -1.50410344360919 0.0796451449000087 no 3089 0.0662773668897453 4503 6496995
SGTC_383 2324-0395 7.37 µM -1.50422232383215 0.0796288445598981 no 3090 0.0662620657864957 4480 3146421
SGTC_372 0155-0182 15.9 µM -1.50450584610455 0.0795899794048308 no 3091 0.066225584606783 4380 771486
SGTC_3027 9089541 49.47 µM -1.5066977607884 0.0792899966051895 no 3092 0.0659440728952224 4494 9943819
SGTC_446 go6976 132 µM -1.51448409046886 0.0782312876646634 no 3093 0.0649515529555788 4507 3501 A protein kinase C inhibitor.
SGTC_1398 3558-0053 112 µM -1.51543318875558 0.0781029751152993 no 3094 0.0648313689392631 4476 4532369
SGTC_869 0564-0080 44.1 µM -1.52472387271364 0.076855347180581 no 3095 0.0636639923686427 4495 6843321
SGTC_2205 7238770 200 µM -1.52494607924636 0.0768256941119536 no 3096 0.0636362736514894 4552 279867
SGTC_182 3448-4371 550.524 µM -1.52555744590928 0.0767441532019224 no 3097 0.0635600583766368 4438 3491403
SGTC_3319 9138450 16.7555 µM -1.52940274168845 0.0762327955559259 no 3098 0.0630823165980616 4447 2029690
SGTC_3236 9132701 49.47 µM -1.53615382470368 0.0753412973861119 no 3099 0.06225032893359 4512 24282524
SGTC_1671 st016596 74.5 µM -1.5369115971651 0.0752417296749768 no 3100 0.0621574795850768 4566 2829167
SGTC_1935 st074532 41.6 µM -1.54884466876056 0.0736869793219712 no 3101 0.0607095323376367 4476 2829742
SGTC_2430 5571206 200 µM -1.55143398489812 0.0733528850800834 no 3102 0.0603988580761071 4499 1731771
SGTC_2584 androsterone 48.74 µM -1.55267969022152 0.0731925675991914 no 3103 0.0602498383752555 4418 2754130 A steroid.
SGTC_2611 pyromycin 23.93 µM -1.56616628089544 0.0714740169466764 no 3104 0.0586548472019637 4474 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_2829 7992743 58.44 µM -1.56676326994365 0.0713986665312528 no 3105 0.0585850178588 4508 16462845
SGTC_1074 carmofur 3.8 µM -1.56725822891396 0.0713362403306027 no 3106 0.0585271723966964 4564 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2525 harmine 47.85 µM -1.56837395888762 0.0711956736887718 no 3107 0.0583969424062197 4542 5280953 A monoamine oxidase inhibitor
SGTC_2616 abietic acid 100 µM -1.57031614917238 0.0709514918381003 no 3108 0.0581707894935132 4550 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_399 oxolinic acid 75 µM -1.57043808623048 0.0709361827909346 no 3109 0.058156613863186 4508 4628 A DNA gyrase inhibitor.
SGTC_566 0958-0068 16.5 µM -1.5722291466704 0.0707116096045688 no 3110 0.0579487090920007 4443 6815365
SGTC_452 diindolylmethane 8 µM -1.57254394435239 0.0706721950208288 no 3111 0.0579122280801596 4527 3071 Inhibits expression of several cancer promoting factors.
SGTC_2946 9065502 71.43 µM -1.57310176398564 0.0706023940796361 no 3112 0.05784762828158 4393 16489101
SGTC_2840 9008771 71.43 µM -1.57472036272312 0.0704001559316534 no 3113 0.0576605027492669 4468 2992978
SGTC_1973 st070275 50.2 µM -1.57847608128026 0.0699326082879496 no 3114 0.0572281394224248 4509 17118334
SGTC_3061 glucosamine 200 µM -1.58211239050991 0.0694822060242618 no 3115 0.0568119577597418 4476 91431 and experimental redox chemotherapeutic
SGTC_2902 5787006 60.46 µM -1.58434042587386 0.0692073417851191 no 3116 0.0565581354835569 4511 591003
SGTC_2890 9046729 58.44 µM -1.58455274173324 0.0691811929674435 no 3117 0.0565339947392111 4515 903329
SGTC_3262 9137218 49.47 µM -1.58627771397197 0.0689690275014698 no 3118 0.0563381627354658 4540 17650664
SGTC_404 fumagillin 50 µM -1.58743180506724 0.0688273586512499 no 3119 0.0562074403447461 4535 12015870 A methionine aminopeptidase binder.
SGTC_2277 7947813 106.88 µM -1.59204741769443 0.0682630175473592 no 3120 0.0556870252815818 4551 1246798
SGTC_854 0422-0053 192 µM -1.59369544339481 0.0680623843985985 no 3121 0.0555021326570072 4562 3596728
SGTC_470 aa-861 153 µM -1.60379745292874 0.0668424837908539 no 3122 0.0543793531113932 4498 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_892 0929-0076 29 µM -1.60410149456616 0.0668060322241802 no 3123 0.0543458412592062 4524 5751038
SGTC_51 1013-0126 23.419 µM -1.61235333742515 0.0658225804398731 no 3124 0.0534425364138961 4537 1627850
SGTC_3327 9140648 26.9345 µM -1.61318250335778 0.0657243844000207 no 3125 0.0533524317771753 4558 8029710
SGTC_577 r071-0003 38.6 µM -1.61691650296106 0.0652835828028486 no 3126 0.0529481528028313 4524 4568517 YMR134W ERG29
SGTC_997 3996-0078 137 µM -1.61718029215889 0.0652525292280072 no 3127 0.052919684565033 4599 735687
SGTC_937 3122-0005 46.7 µM -1.61912649024196 0.0650237745634577 no 3128 0.0527100251101709 4537 759535
SGTC_1729 st035615 45.989 µM -1.62019893967033 0.0648979859296949 no 3129 0.0525947745680043 4545 17385451
SGTC_1192 1488-0095 21.4 µM -1.62213996707082 0.0646708014090047 no 3130 0.0523866911132775 4590 915875
SGTC_792 4534-1957 155 µM -1.62501209670908 0.0643357712426154 no 3131 0.0520799906654505 4527 1717904
SGTC_11 0438-0307 1.3 µM -1.62702046399467 0.064102300259447 no 3132 0.0518663758113517 4555 4011476
SGTC_2295 7971645 200 µM -1.62834516700327 0.063948665533287 no 3133 0.0517258586702155 4589 2978226 YKL099C UTP11
SGTC_1178 0988-0033 191 µM -1.63516152800112 0.0631626494164375 no 3134 0.0510075953648455 4610 5392207
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -1.63631912585406 0.063029913660317 no 3135 0.0508864076540585 4577 390807
SGTC_1797 st048695 56.8 µM -1.63688597399929 0.062964995410557 no 3136 0.0508271485761191 4524 592262 YIL048W NEO1
SGTC_2662 daunorubicin 22.37 µM -1.63694518016246 0.0629582178336198 no 3137 0.0508209622536119 4450 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2795 7780010 54.55 µM -1.63965563389998 0.0626485489890425 no 3138 0.0505383942616542 4523 953673
SGTC_532 1548-0774 215 µM -1.63973154018754 0.0626398938295027 no 3139 0.0505304989947133 4618 5932993
SGTC_10 0279-0212 42.575 µM -1.64119941075668 0.0624727041632797 no 3140 0.0503780140043067 4582 39851 YBR002C RER2
SGTC_2201 6605497 169.863 µM -1.64197929350462 0.062384017579971 no 3141 0.0502971476945346 4536 670741
SGTC_697 0508-1955 564 µM -1.64693693421456 0.0618225391857051 no 3142 0.0497855046459297 4583 6243113
SGTC_2847 9005661 71.43 µM -1.64801578688381 0.0617008777507781 no 3143 0.0496747158352253 4605 2991449
SGTC_1400 3771-8998 51.5 µM -1.65014199066793 0.0614616545752877 no 3144 0.0494569490696031 4529 670767
SGTC_376 3970-0862 59.1 µM -1.65049842382999 0.0614216226086904 no 3145 0.0494205177140086 4578 3135186
SGTC_1564 D-Arginine 115 µM -1.65201532083629 0.0612514835683267 no 3146 0.0492657138244556 4562 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1760 st045453 10.4495 µM -1.658977223581 0.0604753379918201 no 3147 0.0485601909969619 4573 3323419 YIL048W NEO1
SGTC_2444 5485484 36.41 µM -1.66462616451603 0.0598512405156868 no 3148 0.0479936809954254 4604 6790631
SGTC_910 3454-3003 490 µM -1.66512277761463 0.0597966166316753 no 3149 0.0479441316409933 4491 820824
SGTC_2771 fluoxetine 41.05 µM -1.67242144211613 0.0589983129099017 no 3150 0.0472206234145153 4575 3386 A selective serotonin reuptake inhibitor.
SGTC_2130 NSC 7 2.4545 µM -1.6737470073642 0.0588542282505022 no 3151 0.0470901655318138 4615 21448
SGTC_2361 9034121 116 µM -1.67681841297929 0.0585214375383527 no 3152 0.04678899800173 4595 6496917
SGTC_2298 7976326 193.81 µM -1.6775701642542 0.0584402098287084 no 3153 0.0467155206891352 4549 2235818
SGTC_2716 st080858 38.6235 µM -1.67862357883027 0.0583265359944799 no 3154 0.0466127141316515 4565 5296050
SGTC_3231 9132313 49.47 µM -1.68160709032772 0.0580055280155803 no 3155 0.0463225274009501 4558 4905967
SGTC_3334 9142812 21.919 µM -1.68194015992566 0.0579697780426873 no 3156 0.0462902220886849 4571 45283678
SGTC_780 0109-0199 192 µM -1.68959159649182 0.0571532712534634 no 3157 0.0455530573766112 4602 610414
SGTC_2142 5622915 118.518 µM -1.69236124456552 0.0568599554523047 no 3158 0.0452885585075274 4599 5322196
SGTC_969 1313-0238 134 µM -1.6926494052744 0.0568295063960847 no 3159 0.0452611105247733 4608 5212874
SGTC_3281 9140613 49.47 µM -1.69354445440759 0.0567350111923651 no 3160 0.045175940330822 4574 16013766
SGTC_803 4488-1585 147 µM -1.69450481146214 0.0566337587663699 no 3161 0.0450846990936114 4588 747204
SGTC_670 4204-0025 119 µM -1.69600740106553 0.056475623335865 no 3162 0.0449422392285999 4598 719039
SGTC_360 0957-0399 1.01 µM -1.69975349558831 0.0560828922065372 no 3163 0.0445886511290883 4597 6752301 YPR165W RHO1
SGTC_1309 pyrazolanthrone 13.4 µM -1.70526181741151 0.0555093291907371 no 3164 0.0440728026933098 4587 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.70667240474948 0.0553631967730509 no 3165 0.0439414795299194 4605 5393153
SGTC_623 k072-0108 16.9 µM -1.70840022497522 0.0551846141608568 no 3166 0.0437810527754886 4573 5382803
SGTC_2078 5212016 200 µM -1.71337716870003 0.0546727536335269 no 3167 0.0433215869062374 4501 1899708
SGTC_584 0986-0246 15.4 µM -1.71527104598514 0.0544789640814586 no 3168 0.0431477722279503 4658 53315 YDR232W HEM1
SGTC_2447 5741742 33.78 µM -1.71777490444076 0.0542235930637752 no 3169 0.0429188403194959 4638 1776504
SGTC_1663 st014140 55.4 µM -1.71878673936087 0.0541206641301024 no 3170 0.0428266054943109 4654 4207120
SGTC_2866 9034245 58.44 µM -1.72292996638663 0.0537008063271055 no 3171 0.0424505952560792 4602 6462273
SGTC_1509 1326-1131 80 µM -1.72405664415 0.0535870806631186 no 3172 0.0423488089544695 4584 768313
SGTC_601 0986-0029 62.9 µM -1.73872040916677 0.0521242726479919 no 3173 0.0410419771533421 4573 24747981
SGTC_3308 9128332 17.569 µM -1.7434045757282 0.0516637389318014 no 3174 0.0406314847978476 4574 17332805 YDL196W YDL196W
SGTC_733 4069-0007 56.1 µM -1.74412799941319 0.0515929032554623 no 3175 0.0405683863520377 4604 5717425 YNL287W SEC21
SGTC_2859 9028643 45.46 µM -1.74460047306893 0.051546681623447 no 3176 0.040527219219593 4454 17151580
SGTC_1805 st050013 60.3 µM -1.74737826468169 0.0512755985166899 no 3177 0.0402858725906813 4567 4037144
SGTC_1256 0570-0116 285 µM -1.75147377907877 0.0508779897627115 no 3178 0.0399321670333372 4595 410638
SGTC_2212 7123476 200 µM -1.75751544360697 0.0502959267969894 no 3179 0.0394149959196007 4654 1085715
SGTC_1714 st033236 13.627 µM -1.76328857467612 0.0497447052932572 no 3180 0.0389259156515047 4591 2916566
SGTC_1004 4084-0029 199 µM -1.76370373765018 0.0497052518122422 no 3181 0.0388909357628228 4614 716894 YLR208W SEC13
SGTC_1075 aripiprazole 15.2 µM -1.76602630892185 0.0494849951275415 no 3182 0.0386957175789741 4655 60795 An atypical antipschotic. YIL048W NEO1
SGTC_456 gingerol 170 µM -1.76673106535002 0.0494183151526625 no 3183 0.0386366390872091 4610 442793 A herb.
SGTC_1120 ficusin 1.78878 µM -1.76731131560703 0.0493634690854662 no 3184 0.0385880529114596 4600 6199 A DNA cross-linker.
SGTC_1938 st074717 56.4 µM -1.77091584842759 0.0490238513616464 no 3185 0.0382873482367483 4500 17250979
SGTC_3059 1327-0034 3 µM -1.77197671024624 0.0489242536686555 no 3186 0.0381992116705643 4470 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2608 thymoquinone 42.66 µM -1.77595082153223 0.0485525856493409 no 3187 0.0378705116364292 4579 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_3181 9108277 49.47 µM -1.77629033278703 0.0485209387307732 no 3188 0.0378425378905703 4607 17097298
SGTC_1019 4262-0212 3.4 µM -1.77850467776872 0.0483149370363279 no 3189 0.0376605021796912 4607 4677213
SGTC_324 1315-0088 19.6 µM -1.78027178201479 0.0481510448097071 no 3190 0.0375157464094778 4603 6787421
SGTC_1801 st050089 28.441 µM -1.78466850685493 0.0477451952237436 no 3191 0.0371575510620534 4653 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_967 1306-0166 352 µM -1.78683911542487 0.0475458447248261 no 3192 0.0369817476464989 4614 4437607
SGTC_2843 9000894 45.46 µM -1.78781941220884 0.0474560322782514 no 3193 0.0369025739623606 4637 2242070
SGTC_2041 5107442 45.335 µM -1.79912285661134 0.046430227479608 no 3194 0.0359996244106481 4647 793005
SGTC_3164 9100705 49.47 µM -1.80131321503824 0.0462335230148551 no 3195 0.0358267630480173 4645 17174235
SGTC_2341 7987486 176.74 µM -1.80906008021877 0.0455431815510419 no 3196 0.0352208350001547 4629 1258686
SGTC_1553 gossypol 38.6 µM -1.81630473213386 0.044905116514375 no 3197 0.0346618198799287 4606 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_292 k038-0015 474 µM -1.8183517370447 0.0447261385943132 no 3198 0.0345051949607164 4632 46368540
SGTC_2077 5212015 200 µM -1.8217616385479 0.0444292730193022 no 3199 0.0342455803930778 4575 780900
SGTC_2834 9001755 58.44 µM -1.82341542593811 0.044285867327869 no 3200 0.0341202478465524 4493 2989575
SGTC_1867 st057372 64 µM -1.82603436299421 0.0440595335360805 no 3201 0.0339225429548396 4627 688837
SGTC_1459 k035-0031 35.7 µM -1.82821117177172 0.0438721199735076 no 3202 0.0337589324971072 4401 3877128 YMR208W ERG12
SGTC_622 1348-1566 26.3 µM -1.82948402847644 0.043762830934232 no 3203 0.0336635648988329 4636 7340407
SGTC_664 1222-0054 14.9 µM -1.83784153940928 0.0430506896913588 no 3204 0.0330428793036827 4626 6813991
SGTC_2801 7907800 81.82 µM -1.83898600477085 0.0429539030304578 no 3205 0.0329586222851507 4606 6620925
SGTC_2502 avocadyne acetate 18.59 µM -1.83997492611131 0.0428704122930024 no 3206 0.0328859592958709 4611 3952079
SGTC_2331 7980721 200 µM -1.84203323390376 0.0426970580241689 no 3207 0.0327351443831374 4602 2981221
SGTC_2664 lyso-paf C-16 73.48 µM -1.84633979136602 0.0423361854481784 no 3208 0.0324214417506736 4645 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1024 4507-0395 26 µM -1.84717694940958 0.0422663221555388 no 3209 0.0323607494910113 4660 4201836
SGTC_1206 3978-0017 132 µM -1.85103861730703 0.0419452612736533 no 3210 0.0320819988451813 4631 3873677
SGTC_2670 beta-carotene 100 µM -1.8535096413578 0.0417408571089618 no 3211 0.0319046727648745 4652 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2439 5492030 7.2 µM -1.85351746324297 0.0417402113624622 no 3212 0.0319041127372581 4645 5722370
SGTC_578 3460-0051 92 µM -1.8541029638741 0.0416918975170295 no 3213 0.0318622153860211 4676 2876744
SGTC_756 0508-1999 28.3 µM -1.85437981009023 0.0416690687328965 no 3214 0.0318424206095249 4655 6753853
SGTC_3186 9110464 49.47 µM -1.85483573341286 0.041631495289963 no 3215 0.0318098437847966 4635 17018021
SGTC_2702 st077768 96.8 µM -1.85498010676622 0.0416196029510995 no 3216 0.0317995337007617 4605 6484119
SGTC_2991 9074669 71.4286 µM -1.8554080705428 0.0415843668373786 no 3217 0.0317689878918008 4582 17333109
SGTC_1071 trifluoperazine 6.31 µM -1.86228609810988 0.0410213773350552 no 3218 0.0312813869817132 4678 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -1.86264871565823 0.0409918682646606 no 3219 0.0312558528066741 4666 688788
SGTC_629 3448-6466 76.7 µM -1.87004823771733 0.0403934616314978 no 3220 0.0307385597760683 4671 573744
SGTC_1965 Pectolinarigenin 58.4 µM -1.8742405585248 0.0400575847978609 no 3221 0.0304486381217234 4645 5320438 An anti-inflammatory.
SGTC_2619 obliquin 87.91 µM -1.87513874403929 0.0399859207176331 no 3222 0.0303868193207999 4634 6708593 A bioactive alkalod. YER133W GLC7
SGTC_2148 5546263 113.568 µM -1.87961689055706 0.0396301732781713 no 3223 0.0300801548079952 4689 792097
SGTC_1255 0566-0045 221 µM -1.88400415725112 0.0392841456676692 no 3224 0.0297822065703816 4646 2788469
SGTC_772 k072-0172 35.3 µM -1.88886469199982 0.0389036659410979 no 3225 0.02945498081777 4680 5861980
SGTC_2828 7998861 71.43 µM -1.90119957301263 0.0379515575159829 no 3226 0.0286379385047006 4664 2988188
SGTC_1018 4259-0013 28.1 µM -1.90417382858323 0.0377248474712024 no 3227 0.0284437745071444 4677 6801262
SGTC_2313 7726885 200 µM -1.91182415770425 0.0371467830953069 no 3228 0.0279493760550568 4644 726423
SGTC_1022 4477-0945 21.3 µM -1.91447940808546 0.0369478505791518 no 3229 0.0277794638928143 4611 4648966
SGTC_1511 0906-3109 28.5 µM -1.914593977887 0.0369392865983464 no 3230 0.0277721518670954 4658 2882180
SGTC_2396 5342950 42.78 µM -1.91799065228947 0.0366861248642496 no 3231 0.0275560982189349 4631 1886677
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.91884223890306 0.0366228772067446 no 3232 0.0275021512270769 4720 688801
SGTC_1971 st069429 63.5 µM -1.91900163947731 0.0366110483829008 no 3233 0.0274920631813226 4662 1246522 YGL099W LSG1
SGTC_485 niflumic acid 177 µM -1.91994791954836 0.0365408910130693 no 3234 0.0274322390905366 4685 4488 A COX2 inhibitor.
SGTC_742 0kpi-0133 140 µM -1.92082894251465 0.0364756707344119 no 3235 0.0273766381907279 4676 2728852
SGTC_3090 9117696 49.47 µM -1.92393356926539 0.0362466006150388 no 3236 0.0271814554052571 4647 7923821
SGTC_2486 5283202 22.39 µM -1.94027135327434 0.035060472119034 no 3237 0.0261733604524004 4662 1377751
SGTC_865 0488-0499 301 µM -1.94188415590594 0.0349451296348908 no 3238 0.026075562948751 4621 9634651
SGTC_443 clozapine 122 µM -1.95411968758423 0.0340801921225663 no 3239 0.0253435321510456 4664 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1647 st011722 22.4 µM -1.9557574446359 0.0339657653426573 no 3240 0.0252468670617218 4675 2854783
SGTC_1991 st073000 8.92 µM -1.95607854734467 0.0339433676348086 no 3241 0.0252279509333271 4676 4301969 YIL048W NEO1
SGTC_2914 7968218 45.32 µM -1.97468822910014 0.0326659022367288 no 3242 0.024151769771804 4659 2977111
SGTC_2545 solidagenone 89.61 µM -1.98536972536652 0.0319507542919304 no 3243 0.0235516758509038 4667 6708572 An anti ulcer agent
SGTC_417 st075190 100 µM -1.98685744022333 0.031852182387277 no 3244 0.0234690985591072 4666 222757
SGTC_2156 5649887 115 µM -1.99087760163838 0.0315870734530109 no 3245 0.0232471726057055 4706 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2827 7993847 71.43 µM -1.99194608754898 0.0315169198851859 no 3246 0.0231884867388366 4692 2985692
SGTC_2555 cholic acid 100 µM -2.00391279713375 0.0307399847033089 no 3247 0.0225397012337477 4651 6708657 Influences liver metabolism.
SGTC_718 1130-0073 349 µM -2.00600051364427 0.0306060784479571 no 3248 0.0224280965978723 4689 6740020
SGTC_1654 st012436 41.8 µM -2.00794796387354 0.0304816047249258 no 3249 0.0223244107774912 4707 4323132
SGTC_2931 9014674 55.67 µM -2.01535948804061 0.0300117168661862 no 3250 0.0219334979954678 4646 2996810
SGTC_2995 9067767 71.4286 µM -2.01629803936012 0.0299526438317182 no 3251 0.0218844099116143 4675 11673567
SGTC_1989 st071868 50.2 µM -2.02477587741038 0.029423400497935 no 3252 0.021445191571419 4682 16414057
SGTC_2312 7706453 155.7 µM -2.0254446045815 0.0293819865284089 no 3253 0.021410865610655 4657 976098
SGTC_589 1227-0070 34.1 µM -2.03306617618883 0.0289133962677753 no 3254 0.0210229188294015 4721 2841384
SGTC_271 rotenone 740 µM -2.03339891721947 0.0288930809792345 no 3255 0.0210061183287201 4708 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_3214 9129694 49.47 µM -2.04590853087966 0.0281378794259808 no 3256 0.0203826854319841 4671 17158655
SGTC_2634 4'-methoxyflavone 100 µM -2.0462762051898 0.028115934043471 no 3257 0.0203646017132682 4659 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2032 5185112 25.99 µM -2.04964935753183 0.0279152649723082 no 3258 0.0201993301096088 4605 5718189
SGTC_3270 9137563 49.47 µM -2.07420973188654 0.0264898498945038 no 3259 0.0190299184017476 4703 17015724
SGTC_2108 5365811 200 µM -2.07674858911334 0.0263460333384458 no 3260 0.0189123847335532 4711 780283
SGTC_1020 4335-0961 93.3 µM -2.08014998866392 0.0261543804606328 no 3261 0.0187558888662832 4672 669075
SGTC_632 0781-2353 4.65 µM -2.08132767172629 0.0260882958465957 no 3262 0.018701961994623 4724 6811515 YHR007C ERG11
SGTC_2268 7933382 153.85 µM -2.08542069871016 0.0258597044945775 no 3263 0.0185155647966347 4708 935025 YOR257W CDC31
SGTC_581 0958-0271 211 µM -2.09686218119193 0.0252295840170548 no 3264 0.0180028886016502 4709 4591145
SGTC_2541 muurolladie-3-one 83.07 µM -2.09709930259713 0.0252166622594815 no 3265 0.0179923928599032 4655 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2346 9031566 143.75 µM -2.09807691338564 0.0251634466246489 no 3266 0.0179491758013655 4695 4771086
SGTC_1983 st071813 46.9 µM -2.10155207626627 0.0249750396364316 no 3267 0.0177962658255301 4738 11838595
SGTC_881 0833-0569 170 µM -2.10167190481411 0.0249685642477429 no 3268 0.0177910131533039 4711 5418700
SGTC_146 3448-8650 53.125 µM -2.10222082599718 0.0249389192069525 no 3269 0.0177669681523389 4667 2891488 YIL048W NEO1
SGTC_1861 st057647 17.4 µM -2.10326687896818 0.0248825077699366 no 3270 0.0177212234928214 4706 688668
SGTC_2053 5265679 138 µM -2.11430165033264 0.0242939173106488 no 3271 0.0172447557536518 4629 764595
SGTC_1086 cerivastatin 2.18 µM -2.11993195119799 0.0239981320119386 no 3272 0.0170058922076762 4717 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_890 0929-0006 47.2 µM -2.12216695520428 0.0238815590769675 no 3273 0.0169118602120708 4711 1378169
SGTC_2192 5915882 198.485 µM -2.13117191438525 0.0234166909522775 no 3274 0.0165374909465672 4722 2876149
SGTC_839 0122-0028 230 µM -2.13760877873565 0.0230890835429436 no 3275 0.0162742543254356 4716 759448
SGTC_945 3381-0768 11.3 µM -2.15375320517033 0.0222843461445597 no 3276 0.0156297656170821 4703 1126236 YIL048W NEO1
SGTC_44 0929-0055 61.211 µM -2.15776757687471 0.022087959744103 no 3277 0.0154729534641063 4562 1379590
SGTC_841 0251-0215 91.2 µM -2.1747490040479 0.0212732984513481 no 3278 0.0148244652363125 4740 3888614
SGTC_766 1391-0721 126 µM -2.17757674342402 0.0211401402311702 no 3279 0.0147187812743917 4726 1020919 YIL115C NUP159
SGTC_1977 st070720 65.3 µM -2.17801124226349 0.0211197423127929 no 3280 0.0147025998906071 4716 682188
SGTC_261 5-fluorouridine 15.376 µM -2.18162478121598 0.0209507458497698 no 3281 0.0145686182049845 4721 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2027 5150920 200 µM -2.18317258772424 0.0208787095780191 no 3282 0.0145115513265973 4703 786715
SGTC_1615 st002656 86.5 µM -2.19389037794658 0.0203856248000879 no 3283 0.014121645649295 4730 1584458
SGTC_1237 0330-0133 46.1 µM -2.20308375181467 0.0199705705795706 no 3284 0.0137944230893782 4698 X1237 YHR072W ERG7
SGTC_2932 9016711 44.54 µM -2.20434512943123 0.0199141862445526 no 3285 0.0137500406978445 4697 7117328
SGTC_2143 5623677 140.463 µM -2.2243249585863 0.019038936106306 no 3286 0.0130632943233064 4714 5375313
SGTC_1530 rhein 70.4 µM -2.22684911725209 0.0189307240492423 no 3287 0.0129786797283354 4775 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_863 0466-0191 129 µM -2.23526177036181 0.0185738387661182 no 3288 0.0127000841546464 4756 765160 YPR165W RHO1
SGTC_3034 9090421 49.47 µM -2.23908041227976 0.0184137424476105 no 3289 0.0125753422582552 4711 17173761
SGTC_3133 9127736 49.47 µM -2.23921597817445 0.0184080805269147 no 3290 0.0125709333505205 4709 27243420
SGTC_2445 5742597 35.57 µM -2.25727864235667 0.0176668358514917 no 3291 0.0119953345249214 4724 1774255
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -2.2578673990297 0.0176431098105482 no 3292 0.0119769638335651 4757 165521
SGTC_1611 st001856 99.4 µM -2.26387668831325 0.0174024954652123 no 3293 0.0117908500513241 4741 647478
SGTC_1379 2144-0755 36.5 µM -2.26979483704764 0.0171682748561143 no 3294 0.0116100169915313 4740 5392327
SGTC_2550 chrysin dimethyl ether 71.87 µM -2.2768270976321 0.0168934683768026 no 3295 0.0113982763422254 4680 88881 An O-methylated flavonoid and antioxidant.
SGTC_2605 digitonin 300 nM -2.27885351577505 0.016814981588782 no 3296 0.0113378872193444 4724 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_416 estradiol valerate 100 µM -2.28016010758159 0.016764540508553 no 3297 0.0112990971812084 4729 13791 A steroid.
SGTC_786 4544-0069 423 µM -2.28169033463485 0.0167056305843882 no 3298 0.0112538145587416 4716 748821 YLR208W SEC13
SGTC_1759 st043059 70 µM -2.28218825819017 0.0166864999991243 no 3299 0.0112391140133308 4746 669426
SGTC_753 1322-0200 289 µM -2.2859723914781 0.0165417224395485 no 3300 0.0111279368859789 4753 5403907
SGTC_1871 st057448 67.3 µM -2.29483936882989 0.0162066853692464 no 3301 0.0108711657739028 4729 691747
SGTC_1791 st048313 56.1 µM -2.2984584860698 0.0160716177307649 no 3302 0.0107678540286185 4751 1204976
SGTC_834 0312-0008 75.7 µM -2.30493518795587 0.0158323106073949 no 3303 0.0105851017612708 4762 6385573 YIL048W NEO1
SGTC_1872 amphotericin b 148 nM -2.30892692593705 0.0156863474537604 no 3304 0.0104738182740214 4752 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -2.3108741913141 0.0156155630842686 no 3305 0.0104199024965253 4737 4000243
SGTC_2390 9097792 176.6 µM -2.33567379106873 0.0147377852659743 no 3306 0.00975412473286005 4758 4497149
SGTC_152 4469-0003 551.229 µM -2.33845822529458 0.0146419330997491 no 3307 0.00968174515932438 4735 697280
SGTC_900 1112-0045 141 µM -2.34575050055353 0.014393439838483 no 3308 0.00949440689835262 4705 56211 YIL048W NEO1
SGTC_1876 myriocin 605 nM -2.34775155040325 0.0143258898179919 no 3309 0.00944355744980854 4704 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_2667 digitoxin 100 µM -2.3549284511811 0.0140858579043575 no 3310 0.00926313623328368 4751 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2965 9082772 38.63 µM -2.36516484045127 0.0137495023589071 no 3311 0.00901102369728962 4723 16459634
SGTC_2791 5663188 71.43 µM -2.36903407369591 0.0136241805274369 no 3312 0.00891730515526963 4727 54690634
SGTC_2808 7946468 45.46 µM -2.37276244703936 0.0135043548247267 no 3313 0.00882780752214294 4724 2970879
SGTC_862 0452-0056 10.2 µM -2.38537018899445 0.0131058716808175 no 3314 0.00853097134271518 4736 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_588 3970-1144 52.9 µM -2.40045795423557 0.0126423975510274 no 3315 0.008187285888841 4704 1888707
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -2.40307310219141 0.0125635233650502 no 3316 0.00812896852098335 4754 688662
SGTC_746 1095-0025 46.6 µM -2.41850181553709 0.0121068019154881 no 3317 0.00779228389569819 4756 6749286
SGTC_938 3126-1755 342 µM -2.44762303078638 0.0112838685534707 no 3318 0.00719010103712313 4758 1777771
SGTC_2629 bisabolol 100 µM -2.45051209089032 0.0112049415908837 no 3319 0.00713265857713888 4744 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_3004 9076122 71.4286 µM -2.46440399852551 0.0108320918165946 no 3320 0.00686206614997693 4751 44782551
SGTC_2139 5578692 56.4705 µM -2.47134234411014 0.0106499486631931 no 3321 0.00673034445582165 4754 650991 YMR113W FOL3
SGTC_284 0988-0104 32.6 µM -2.51092522480092 0.00966101005313605 no 3322 0.0060207600207267 4747 4666532
SGTC_1340 1486-1359 257 µM -2.53276431470855 0.00915050641776791 no 3323 0.00565835073002322 4741 4309068
SGTC_2167 5876490 200 µM -2.54223607252892 0.00893654321943629 no 3324 0.00550728757866729 4750 686534
SGTC_1748 st037455 53.6035 µM -2.55441582120911 0.0086678580747311 no 3325 0.00531830728061672 4743 580690
SGTC_2164 5685496 200 µM -2.55634274108067 0.00862600575830219 no 3326 0.00528894359368173 4759 759046
SGTC_492 tmb-8 126 µM -2.59146027132903 0.00789371229117174 no 3327 0.00477847877992751 4790 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1273 0849-0096 14.1 µM -2.61400749389985 0.00745289056414724 no 3328 0.00447435368593732 4773 5286025
SGTC_1457 k015-0032 57.3 µM -2.61739387380274 0.00738859185254492 no 3329 0.00443020178515633 4774 4302660
SGTC_1695 st026914 34.495 µM -2.63415568730027 0.00707747395636653 no 3330 0.0042173401308032 4781 3289191
SGTC_1961 st076550 68.7 µM -2.6406819026365 0.00695950265479954 no 3331 0.00413696815467996 4777 1579337
SGTC_2010 4012422 159 µM -2.66585048968133 0.00652064050713277 no 3332 0.00383969183725742 4744 952393
SGTC_1293 1000-1278 195 µM -2.67856100850591 0.00630845364428545 no 3333 0.00369696305479831 4773 678847
SGTC_575 k072-0246 11.9 µM -2.71625766059987 0.00571466113887108 no 3334 0.00330122559163744 4799 6796779
SGTC_2784 7567673 72.73 µM -2.76089068768762 0.00507615316838634 no 3335 0.00288219832631429 4738 3471247
SGTC_1521 st012942 49.4 µM -2.77031606276565 0.00494973535598925 no 3336 0.00280009603952735 4731 24207259
SGTC_2915 7971052 15.16 µM -2.82316722399253 0.00429147244015413 no 3337 0.00237758810457825 4774 5741558
SGTC_2557 derrustone 83.84 µM -2.90906399610739 0.00338725513970609 no 3338 0.00181256322439206 4781 629853 An antioxidant.
SGTC_2157 5649910 96.377 µM -2.91921582615984 0.00329258270492391 no 3339 0.00175456588150366 4774 2858091
SGTC_1026 k007-1105 30.6 µM -2.93501010426298 0.0031500157150647 no 3340 0.00166768413315354 4760 7066794
SGTC_464 bw-b 70c 158 µM -2.94022537692366 0.00310417509710477 no 3341 0.0016398679558617 4786 5353454
SGTC_179 1273-0063 6.77 µM -2.95758409287574 0.0029558921074498 no 3342 0.00155030081326939 4764 3108139
SGTC_25 0118-0223 35.662 µM -2.96220982450399 0.00291747033775218 no 3343 0.00152719779637592 4784 5333628
SGTC_1021 4476-0760 85.3 µM -3.02989202680146 0.00240451917896009 no 3344 0.00122320590347574 4793 746768
SGTC_3344 9148862 3.898 µM -3.24813455222279 0.00125748621202968 no 3345 0.000580821620518576 4805 4905352
SGTC_2406 ethylparaben 405.7 µM -3.25165554938863 0.00124401753669122 no 3346 0.000573674875580517 4763 8434 A possible steroid mimic.
SGTC_1370 2001-0092 44.6 µM -3.30833884589032 0.00104459212022184 no 3347 0.000469255906964146 4756 790957
SGTC_425 3825-7017 13.1 µM -3.40158314887847 0.000779292442490238 yes 3348 0.000334983720941358 4791 3397440
SGTC_2628 lathosterol 100 µM -3.48159279324692 0.000602707116273804 yes 3349 0.000249220523552348 4795 6710616
SGTC_1578 josamycin 24.2 µM -3.56116749834314 0.000464415970174082 yes 3350 0.000184604724865294 4803 5282165 A P450 substrate.
SGTC_2623 humulene 100 µM -3.59696526789495 0.000412346582644724 yes 3351 0.000160975726425799 4789 6187145 An anti-inflammatory.
SGTC_1730 st033808 45.1 µM -3.60600962544025 0.000400076873896042 yes 3352 0.000155470803776924 4789 1045166
SGTC_2543 pimpinellin 60.67 µM -3.90544053013519 0.000141787548867142 yes 3353 4.70269436674992e-05 4794 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2004 4023728 41.89 µM -3.99625236322593 0.000102042825010669 yes 3354 3.21765658088361e-05 4799 360084 YDR527W RBA50
SGTC_38 0929-0051 58.268 µM -4.40032129381318 2.17681824994037e-05 yes 3355 5.40453570803162e-06 4806 1379719
SGTC_2412 st077135 33.4 µM -5.37064725110174 3.08395303246713e-07 yes 3356 3.92272704399079e-08 4807 13258915