SGTCid condition conc unit YCL042W|YCL042W.score YCL042W|YCL042W.strain.pval YCL042W|YCL042W.strain.significant YCL042W|YCL042W.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_1377 2944-0135 198 µM 7.80757422159352 4.69051938414348e-13 yes 1 2.91495725996467e-15 7 1894137 SGTC_2397 5161689 200 µM 5.39787802623653 4.03799554016936e-07 yes 2 3.37168422321715e-08 10 2259942 SGTC_486 niguldipine 82 µM 4.95226498378537 3.01094318714433e-06 yes 3 3.66773109625187e-07 9 1236 A calcium channel blocker. SGTC_2400 5203494 178.7 µM 4.84671405906699 4.733532753298e-06 yes 4 6.2761570144434e-07 14 6777674 SGTC_1952 st077036 64.1 µM 4.70669409584157 8.50797109201471e-06 yes 5 1.25883134360581e-06 16 2937007 SGTC_3207 9114163 49.47 µM 4.70306052209644 8.63660304555676e-06 yes 6 1.28145203582957e-06 13 849233 SGTC_1673 st016611 27.3 µM 4.58520037853777 1.39712235551398e-05 yes 7 2.26775625606124e-06 29 5226799 SGTC_469 w7 172 µM 4.57601001486293 1.4498391086863e-05 yes 8 2.36963933491301e-06 8 45115570 A P450 inhibitor. SGTC_489 paxilline 115 µM 4.52133932614958 1.80467657108859e-05 yes 9 3.07247964763168e-06 7 105008 A toxic potassium channel blocker. SGTC_137 0438-0332 85.389 µM 4.49330915782719 2.01717905271533e-05 yes 10 3.50624326583897e-06 94 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_1267 0828-0272 9.49 µM 4.37867084636603 3.15955539979663e-05 yes 11 5.97026575858572e-06 13 745334 SGTC_787 4152-0075 138 µM 4.21196862333809 5.95500032795698e-05 yes 12 1.26577357432033e-05 20 9566539 SGTC_638 3970-0837 4.09 µM 4.20197128473431 6.18135123327821e-05 yes 13 1.32300352025763e-05 30 4118451 YLR208W SEC13 SGTC_1371 2421-0008 32.7 µM 4.15027382164309 7.48708385313915e-05 yes 14 1.66038884731947e-05 28 2827552 SGTC_460 trequinsin 123 µM 4.1422841558939 7.71068740117169e-05 yes 15 1.71931966630537e-05 1 5537 A vasodilator. SGTC_1625 st003711 30.1 µM 4.10378779604401 8.87898829339154e-05 yes 16 2.03220146004884e-05 31 24207034 YER133W GLC7 SGTC_1011 4112-3381 17.4 µM 4.10098429343767 8.97027010513539e-05 yes 17 2.05698243084194e-05 37 2877139 SGTC_2517 totarol 10 µM 3.98654397617482 0.000135462102843888 yes 18 3.35213531160568e-05 18 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_2016 5121758 140 µM 3.80458068601194 0.000255370584816939 yes 19 7.10223031799558e-05 60 2795203 SGTC_3210 9128157 49.47 µM 3.71691322112186 0.0003433807303588 yes 20 0.000100835837023176 55 17590849 SGTC_3011 9081274 71.4286 µM 3.71671946695537 0.000343603228063517 yes 21 0.000100913164169132 22 6625322 SGTC_1473 k844-0725 134 µM 3.69502983739435 0.000369375084777909 yes 22 0.000109930483536738 21 54682906 SGTC_973 1325-0077 65.9 µM 3.65915254989831 0.000415978567109715 yes 23 0.000126525339321942 14 2835149 SGTC_1062 mesoridazine 14.2 µM 3.56961642655059 0.000557102885668898 yes 24 0.000178752152693621 25 4078 A neuroleptic. SGTC_2149 5554786 194.827 µM 3.55240738404868 0.000588851321249951 yes 25 0.000190861685212454 50 745063 YPR165W RHO1 SGTC_1459 k035-0031 35.7 µM 3.54625374560261 0.000600604014925504 yes 26 0.000195374878006129 34 3877128 YMR208W ERG12 SGTC_633 0437-0093 97.7 µM 3.49851639850577 0.000699407194098491 yes 27 0.000233927159202545 24 2831118 SGTC_2213 7173844 200 µM 3.48203141669689 0.000736869266135508 yes 28 0.000248812652788951 28 892728 SGTC_456 gingerol 170 µM 3.44955466601956 0.000816136396466018 yes 29 0.000280756014127398 35 442793 A herb. SGTC_2399 5884133 200 µM 3.36145332461555 0.00107233257562006 no 30 0.000387667297584576 104 722445 SGTC_621 3584-0052 32.1 µM 3.34458865852886 0.00112908255831463 no 31 0.000412023436006592 40 2273927 SGTC_1684 st024538 14.6195 µM 3.33584123996855 0.00115958949276509 no 32 0.000425208567726581 24 6732859 SGTC_1460 k062-0059 9.15 µM 3.33544695287736 0.00116098220041316 no 33 0.000425812000925023 36 1373085 SGTC_2933 9026794 32.47 µM 3.32589341632784 0.00119519913162529 no 34 0.000440678117909101 53 17586027 SGTC_2524 avocatin b 10.57 µM 3.29272110185307 0.00132130119113752 no 35 0.000496114235027481 42 6710748 SGTC_1701 st028638 40.4 µM 3.25785267178917 0.00146686252313158 no 36 0.000561293356154024 37 3490878 SGTC_1370 2001-0092 44.6 µM 3.22330804417762 0.00162536296051624 no 37 0.000633595994002703 73 790957 SGTC_87 0100-0052 35.5 µM 3.20921482678129 0.00169439331468375 no 38 0.000665490026100931 188 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_2449 5812982 45.77 µM 3.20367961671618 0.0017222278600155 no 39 0.000678416871904103 28 776185 SGTC_2800 7887935 81.82 µM 3.20112184788124 0.00173523000361501 no 40 0.000684468149200992 63 2961002 SGTC_905 2-aminofluorene 215 µM 3.17550411659971 0.00187047048624874 no 41 0.000747881996534075 59 1539 An established DNA mutagen. YPR165W RHO1 SGTC_1112 tnp00069 1.16933 µM 3.16569266616582 0.00192475529189752 no 42 0.00077357082202162 57 145826 SGTC_1940 st075990 51.1 µM 3.15500765024964 0.00198549832368959 no 43 0.00080246948464027 53 1084979 SGTC_454 lyso-paf C-16 6.67 µM 3.1547385086424 0.00198705059083489 no 44 0.000803210071081995 52 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_635 k038-0028 24.7 µM 3.15241072843555 0.00200052205145789 no 45 0.000809641633133345 80 4035102 SGTC_1286 0929-0070 131 µM 3.14530258493135 0.00204217348054584 no 46 0.000829575646588056 52 1420408 SGTC_972 1319-0219 195 µM 3.13937564508904 0.00207750346604474 no 47 0.000846541288095078 65 23903702 SGTC_622 1348-1566 26.3 µM 3.09730224167934 0.00234466541255889 no 48 0.000976453245851724 54 7340407 SGTC_2777 climbazole 1.536 µM 3.09536014856789 0.00235771708216575 no 49 0.000982870247497543 93 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_1677 st019204 53.9 µM 3.03201886335727 0.00282114757714948 no 50 0.00121462011336122 63 3945625 SGTC_1949 st076024 69.1 µM 3.01298098095349 0.0029756825118946 no 51 0.0012934756489978 66 2921930 SGTC_1169 aniline yellow 25.8 µM 3.00827070154204 0.00301507554201453 no 52 0.00131369494612411 36 6051 A DNA damaging agent. SGTC_3352 9151559 45.5865 µM 2.99456593740557 0.00313237742137523 no 53 0.0013741782267267 43 17159339 SGTC_1237 0330-0133 46.1 µM 2.97236087518017 0.00333117581773281 no 54 0.00147759554137238 62 X1237 YHR072W ERG7 SGTC_1709 st033179 39.1045 µM 2.93049279250554 0.0037371148597384 no 55 0.00169212422158383 57 573381 SGTC_2334 9017922 200 µM 2.91637815953033 0.00388364812981684 no 56 0.00177060501735027 70 3163164 SGTC_840 0245-0196 390 µM 2.87269491556956 0.00437032538155559 no 57 0.00203493466151923 62 3827528 SGTC_1478 0453-0656 35.7 µM 2.86195472282544 0.00449803442947987 no 58 0.00210518524966323 51 5258496 SGTC_2512 diallyl trisulfide 49.23 µM 2.82568691982738 0.00495426922590621 no 59 0.00235896761353987 45 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_1002 4049-0206 172 µM 2.81886590207114 0.00504454106638564 no 60 0.00240968236735004 114 4662749 SGTC_3051 9093778 49.47 µM 2.80180210090399 0.0052768162905088 no 61 0.00254090182356213 29 17217378 SGTC_1446 4239-0190 62 µM 2.7955966794426 0.00536361552304162 no 62 0.00259020023753297 100 1340085 SGTC_134 0269-0018 6.916 µM 2.7596338639943 0.00589209760775374 no 63 0.00289330871874793 220 4378915 SGTC_2147 5545932 89.7195 µM 2.75503730412646 0.00596287054741565 no 64 0.00293427219989032 60 797404 SGTC_3097 9117246 49.47 µM 2.74745268616514 0.00608129929998897 no 65 0.00300300869099362 77 16423892 SGTC_2442 5158906 48.48 µM 2.71058539483039 0.00668714597403417 no 66 0.00335822755581929 86 1893835 SGTC_15 0266-0086 27.098 µM 2.69969925232458 0.00687595976482009 no 67 0.00347010914772157 171 1712902 YIL048W NEO1 SGTC_598 3937-0236 20.2 µM 2.69863984418413 0.0068945835993471 no 68 0.0034811739522625 122 1379313 SGTC_225 nsc-122657 1.016 µM 2.6946179982327 0.00696569169534131 no 69 0.00352346850041895 38 275685 SGTC_3008 9078912 71.4286 µM 2.67266048404222 0.00736544233294215 no 70 0.00376261849648106 76 16648731 SGTC_594 1487-1584 10.8 µM 2.66035960307932 0.00759811216661414 no 71 0.00390286312508466 86 5013332 SGTC_2060 5238662 140 µM 2.65233769362275 0.00775331005411125 no 72 0.00399682746932125 100 790130 SGTC_855 0428-0020 25 µM 2.63747449145157 0.00804825063146971 no 73 0.0041762953614974 74 6812414 SGTC_2889 9059656 51.95 µM 2.63056597053882 0.00818866698144307 no 74 0.00426214117581849 69 3949838 SGTC_971 1315-0384 26.7 µM 2.62861709799302 0.00822866523009359 no 75 0.0042866416601746 106 6769120 SGTC_2265 7929201 200 µM 2.59315242609241 0.008987108592259 no 76 0.00475503057248802 110 1265108 SGTC_970 1315-0089 19.5 µM 2.58670192501551 0.00913145411807435 no 77 0.00484496879949184 92 6811083 YLR033W RSC58 SGTC_453 enantio-paf c16 10 µM 2.58012520987226 0.00928070971313591 no 78 0.00493822490618079 332 13871343 A lipid and platelet activating factor SGTC_1696 st025591 34.7925 µM 2.57292707022099 0.00944651103850155 no 79 0.00504212274052659 122 2787147 SGTC_465 cgp-37157 41 µM 2.56119356286137 0.00972233486448306 no 80 0.00521566100199253 52 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_2388 9080168 200 µM 2.56093806296443 0.00972841846280998 no 81 0.00521949824614053 63 15943073 SGTC_1447 4239-0816 81.9 µM 2.55551119487484 0.00985842313108345 no 82 0.00530159751508791 117 1341554 SGTC_2803 7707263 71.43 µM 2.54969314884834 0.00999948142658103 no 83 0.00539088845914586 111 2199229 SGTC_6 0844-0013 19.835 µM 2.5465065769693 0.0100774839311326 no 84 0.00544035805753585 292 1584900 SGTC_2956 9076196 2.52 µM 2.54420861073022 0.0101340637191799 no 85 0.00547628256777014 109 16423868 SGTC_1734 st037168 69.4 µM 2.53538578745306 0.0103538790973956 no 86 0.00561617746913455 117 708907 SGTC_3206 9114350 49.47 µM 2.52514681864765 0.0106141778165843 no 87 0.00578249810610387 98 17087243 SGTC_2208 7283366 200 µM 2.49811984698211 0.0113288235482862 no 88 0.00624269876749596 86 898663 SGTC_2401 5128683 200 µM 2.49160589998005 0.0115071926415401 no 89 0.00635835255922047 133 708373 SGTC_1302 1159-0335 255 µM 2.48668698975989 0.0116434970264846 no 90 0.00644693945805344 91 649284 SGTC_2931 9014674 55.67 µM 2.4831119549036 0.0117434397903794 no 91 0.00651200738367509 128 2996810 SGTC_1838 st055369 84.5 µM 2.47175512244132 0.0120658836112746 no 92 0.0067225789184924 106 676036 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 2.46635580360905 0.0122218549457548 no 93 0.00682478368337676 110 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_47 0149-0135 24.25 µM 2.45956267784711 0.0124205691044086 no 94 0.00695532027193777 118 5239155 SGTC_2479 5617353 43.85 µM 2.45747731045816 0.0124821294445716 no 95 0.00699583244200392 143 2731746 SGTC_2539 epi(13)torulosol 80 µM 2.44815531479473 0.0127605569371681 no 96 0.00717948720548777 129 6708597 SGTC_2992 9074591 71.4286 µM 2.44470877554208 0.0128648495997983 no 97 0.00724845743462273 99 17741321 SGTC_709 3807-1509 243 µM 2.43354127773999 0.0132078594626286 no 98 0.00747596525058699 89 1886677 YPL242C IQG1 SGTC_1702 st027038 51 µM 2.41156332739817 0.0139060420827517 no 99 0.0079421465418028 117 5521182 SGTC_906 1165-0455 526 µM 2.40926252987293 0.0139809401292184 no 100 0.00799239743774149 82 3252859 SGTC_1166 k206-0078 225 µM 2.40899640454004 0.0139896257253989 no 101 0.00799822778440254 133 5404595 SGTC_2117 5521686 200 µM 2.40781176546866 0.0140283455338466 no 102 0.00802422657587776 132 803312 SGTC_459 nigericin 15.3 µM 2.37593190652775 0.0151055822958724 no 103 0.00875234640688614 188 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_2883 9059145 45.46 µM 2.37200935169711 0.0152429155988225 no 104 0.00884582146362214 95 16476510 SGTC_1707 st032323 6.317 µM 2.35973403415008 0.0156796399183084 no 105 0.00914402066338911 204 3132057 YMR211W DML1 SGTC_1445 4239-0156 97.7 µM 2.35640789737738 0.0157998078122901 no 106 0.00922632147838892 148 4008346 SGTC_2432 5630864 12.22 µM 2.34679610990892 0.0161515147375543 no 107 0.00946780672932334 164 5714970 SGTC_2152 5568786 200 µM 2.34569915304411 0.016192076985936 no 108 0.00949571485409823 120 5399883 SGTC_765 1319-0117 244 µM 2.33279306813898 0.0166758970040279 no 109 0.00982950433516703 117 3487746 YGL099W LSG1 SGTC_168 3970-0862 530.542 µM 2.32981162179881 0.016789407130679 no 110 0.00990805482560932 363 3135186 SGTC_303 1348-1668 34.2 µM 2.32891082562259 0.0168238321320975 no 111 0.00993189515773816 108 5380509 SGTC_1197 1601-0112 267 µM 2.31873558510238 0.0172169019183484 no 112 0.0102046888905882 166 7350313 SGTC_471 1-acyl-paf 4 µM 2.31516036045919 0.0173568632967018 no 113 0.0103020788509937 135 16759367 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 2.31399247949516 0.0174027930645991 no 114 0.0103340673347785 367 16725076 SGTC_2897 9048598 12.99 µM 2.30469554433219 0.0177721330483335 no 115 0.0105918153085007 118 6467404 SGTC_1163 k060-0048 49.9 µM 2.29203923597447 0.0182856642481278 no 116 0.0109516895974221 166 6809982 SGTC_2314 7727897 200 µM 2.29071563779405 0.0183400924678738 no 117 0.0109899327948433 137 900724 SGTC_1274 0865-0114 173 µM 2.29037623141009 0.0183540715482023 no 118 0.0109997580812691 149 870624 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 2.29036872538555 0.0183543808002772 no 119 0.010999975455334 163 5106787 A p450 inhibitor. SGTC_260 nsc-65238 3.989 µM 2.28674693188203 0.0185041192710205 no 120 0.0111052993107266 133 3246252 SGTC_3333 9141820 12.094 µM 2.2860849423432 0.0185316005347058 no 121 0.0111246448599492 116 1939433 SGTC_2240 6690706 185.951 µM 2.25827270949758 0.019717986621281 no 122 0.0119643313106691 125 805876 SGTC_589 1227-0070 34.1 µM 2.25048389097214 0.0200615708795253 no 123 0.0122091224824643 147 2841384 SGTC_2694 st077685 81.9 µM 2.24516780699265 0.0202989813303239 no 124 0.0123786809710186 181 2838096 SGTC_719 2810-4230 27.3 µM 2.24479810387661 0.0203155800722815 no 125 0.012390548280876 81 721079 SGTC_2872 9044037 25.97 µM 2.23840922541017 0.0206042470652084 no 126 0.0125971904891537 90 6465195 SGTC_1573 oleylamine 1.06 µM 2.23340282670511 0.0208328710639899 no 127 0.0127611959752293 188 5356789 An amine of the fatty acid oleic acid. SGTC_757 1066-0008 322 µM 2.23209403344446 0.0208929917848292 no 128 0.0128043743502544 165 6842497 SGTC_2604 4'-hydroxychalcone 11.32 µM 2.22761971477541 0.0210996344920082 no 129 0.0129529424306645 184 5282362 SGTC_2749 bexarotene 57.39 µM 2.22239690990268 0.0213430301374978 no 130 0.0131282469952869 196 82146 An retinoic acid receptor inhibitor. SGTC_624 k048-0052 28 µM 2.22144566383912 0.0213876151737804 no 131 0.0131603955432012 161 6835531 SGTC_159 3970-0959 50 µM 2.21050827387371 0.021905934653542 no 132 0.0135349534688243 346 6615653 SGTC_982 1491-0518 27.5 µM 2.20201395316306 0.0223157598620541 no 133 0.0138321614333982 148 3091256 SGTC_2892 9047358 58.44 µM 2.19993715005741 0.0224169375604528 no 134 0.0139056772437696 105 6466771 SGTC_1000 4048-0884 8.67 µM 2.19894131262824 0.0224655898419934 no 135 0.0139410477805663 184 13040088 SGTC_475 α-linolenic acid 10 µM 2.1933988292414 0.0227380012637999 no 136 0.0141393283042199 185 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_59 0330-0160 1.33 µM 2.18854521465415 0.0229788362300681 no 137 0.0143149557522029 348 4293482 SGTC_1629 st005085 44.9 µM 2.1879168846307 0.0230101702976329 no 138 0.014337828576851 208 24207091 SGTC_1732 st034308 51.822 µM 2.1829635290909 0.0232584505000568 no 139 0.014519247961092 187 830119 SGTC_786 4544-0069 423 µM 2.17996122720316 0.0234100315498355 no 140 0.0146301678694125 195 748821 YLR208W SEC13 SGTC_18 0111-0177 500 nM 2.17394854157208 0.0237161018709168 no 141 0.0148544999828334 268 721752 SGTC_234 nsc-17383 10.7 µM 2.1653636241942 0.0241589358413471 no 142 0.0151799247295245 189 408974 SGTC_3167 9103034 49.47 µM 2.16531176995269 0.0241616315875315 no 143 0.0151819088079373 83 5127859 SGTC_2382 9035899 200 µM 2.1648798904293 0.0241840935232619 no 144 0.0151984423006818 172 6462679 SGTC_1105 epirubicin 18.1 µM 2.16225099903375 0.0243212000849655 no 145 0.0152994172362818 164 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_994 3910-0338 138 µM 2.16039229589794 0.0244185318068637 no 146 0.0153711566749889 208 3479481 SGTC_2939 9044578 71.43 µM 2.15032207159564 0.0249515652477899 no 147 0.0157648738555107 208 2653634 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 2.14734223163054 0.0251111512108714 no 148 0.0158830230129519 177 16486 A toxic proline analog. SGTC_1018 4259-0013 28.1 µM 2.13705132235779 0.0256688764348221 no 149 0.0162969087662418 167 6801262 SGTC_2689 tacrolimus 100 µM 2.11916510801628 0.0266629032243193 no 150 0.0170382579617715 217 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_125 0133-0007 11.75 µM 2.11726768795316 0.0267702138592251 no 151 0.0171185677907286 161 26541 SGTC_1205 4161-2785 76 µM 2.0999517492272 0.0277662997312572 no 152 0.0178665429128357 196 3498106 SGTC_1867 st057372 64 µM 2.09644230986809 0.0279718961774365 no 153 0.0180214862374468 178 688837 SGTC_869 0564-0080 44.1 µM 2.09113635879958 0.0282851456729033 no 154 0.0182579211268084 217 6843321 SGTC_1451 4152-0210 104 µM 2.08155270487206 0.0288583384968672 no 155 0.0186916726119929 217 659563 SGTC_2806 7952793 58.44 µM 2.07941397054605 0.0289875642508209 no 156 0.0187896587616372 198 2972490 SGTC_1146 3579-1023 7 µM 2.07765846067067 0.0290939940040338 no 157 0.0188704137805867 220 X1146 SGTC_2903 5923464 63.88 µM 2.07533057201863 0.0292356253814753 no 158 0.0189779539508039 149 2876576 SGTC_338 4055-0136 114 µM 2.0656801488722 0.0298288895817383 no 159 0.0194293454538337 202 2900563 SGTC_2233 sulbentine 40.3845 µM 2.06247864781051 0.0300278959965955 no 160 0.019581094180433 262 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_1438 4092-1045 4 µM 2.06199951469566 0.0300577735738429 no 161 0.0196038910891496 175 1351342 SGTC_98 0074-0023 107.663 µM 2.06086753916019 0.0301284587362644 no 162 0.0196578394438274 244 3563821 SGTC_60 0986-0278 202 µM 2.05291165851716 0.0306291535449167 no 163 0.0200405730547167 137 3110598 SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 2.05224654323604 0.0306713221700876 no 164 0.0200728541387181 211 6708784 An antioxidant flavonoid SGTC_616 4092-0450 108 µM 2.03797345266324 0.0315878897703898 no 165 0.0207762939338854 230 787165 SGTC_2212 7123476 200 µM 2.02009561709132 0.0327677587811966 no 166 0.0216867352021868 123 1085715 SGTC_3156 9099931 49.47 µM 2.01309915003887 0.0332392844424129 no 167 0.0220520998213961 201 18111053 SGTC_1480 1070-0044 41.2 µM 2.00772705880396 0.0336051166312351 no 168 0.0223361517987091 218 3124987 SGTC_2155 5570423 76 µM 2.00284276032967 0.0339406008422416 no 169 0.0225970842669952 182 797402 SGTC_1049 3226-0134 66 µM 1.99687958539692 0.034353918561184 no 170 0.0229191326785177 250 5702385 SGTC_794 k038-0031 316 µM 1.99270243590134 0.0346459003380077 no 171 0.023147020249746 325 6624242 SGTC_1243 0416-0003 5.65 µM 1.98637010868277 0.0350924126973859 no 172 0.0234961215771907 263 2141977 SGTC_2378 9074213 121.43 µM 1.97963417042912 0.0355725568703096 no 173 0.0238723252414116 245 657714 SGTC_2945 9067681 61.76 µM 1.97454352993625 0.0359389845752092 no 174 0.0241599864366388 185 16456930 SGTC_2276 7947513 42.08 µM 1.9715931557619 0.0361527660004354 no 175 0.0243280345711567 231 2105100 SGTC_839 0122-0028 230 µM 1.96939434874247 0.0363127658103162 no 176 0.0244539121026588 300 759448 SGTC_3241 9133421 49.47 µM 1.96509153147439 0.0366275443088977 no 177 0.0247018222952385 106 17018221 SGTC_2895 9054447 58.44 µM 1.96263339059315 0.0368083725619259 no 178 0.0248443939775489 172 2697450 SGTC_2339 9000433 200 µM 1.96053144545181 0.0369635764064129 no 179 0.0249668531456119 220 2988954 SGTC_2248 tofa 1.1 µM 1.95858643285758 0.0371076688042817 no 180 0.0250806198646566 219 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1846 st056244 14.8 µM 1.95852016382342 0.0371125862895402 no 181 0.0250845036826462 259 5393182 SGTC_1366 1683-0113 21.9 µM 1.95830287576904 0.0371287138580978 no 182 0.0250972417831849 196 708623 SGTC_877 0771-0151 33.1 µM 1.95668872631212 0.0372486987521217 no 183 0.0251920380769831 235 6166523 SGTC_1947 st076332 61.6 µM 1.95261478623542 0.0375529370025591 no 184 0.0254326288760538 179 24208416 SGTC_333 3486-0131 40.1 µM 1.94606423405357 0.038046378236965 no 185 0.0258235120930145 220 6744690 SGTC_1192 1488-0095 21.4 µM 1.94275504509644 0.0382976570594551 no 186 0.0260228809621483 210 915875 SGTC_935 2996-0153 430 µM 1.94248453392953 0.0383182576491077 no 187 0.0260392352322549 218 23738523 SGTC_552 k242-0005 476 µM 1.93864572225132 0.0386115746748936 no 188 0.0262722460302351 202 4088318 SGTC_2761 levamisole 97.89 µM 1.93681196818345 0.0387523330047607 no 189 0.0263841662016306 218 26879 An alkaline phosphatase inhibitor. SGTC_2757 clomiphene 4.22 µM 1.93532516020256 0.038866766483677 no 190 0.0264752033624264 285 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_3005 9076496 71.4286 µM 1.93321065344579 0.0390299852134097 no 191 0.0266051264527094 185 21368410 SGTC_775 4577-0580 57.3 µM 1.93158612439756 0.0391557612781285 no 192 0.0267053049168669 215 2006902 SGTC_1694 st024011 44.9 µM 1.93059488164378 0.0392326682935875 no 193 0.0267665856675764 259 2787533 SGTC_3148 9097893 49.47 µM 1.92956368954512 0.0393128052592076 no 194 0.026830460750869 256 17174100 SGTC_1665 st014639 11.4 µM 1.9235317392889 0.0397842379816624 no 195 0.0272066522021118 276 981133 YIL048W NEO1 SGTC_544 k015-0020 52.4 µM 1.92157517257835 0.0399381388100173 no 196 0.0273296175436246 230 3008304 SGTC_1488 4013-0813 75.9 µM 1.92131046092209 0.0399589977726248 no 197 0.0273462895553626 184 2910057 SGTC_647 0140-0236 81 µM 1.91949980800375 0.0401019125696698 no 198 0.0274605552831342 265 990837 SGTC_845 0330-0138 4.51 µM 1.91806255250559 0.0402156505327375 no 199 0.0275515400193657 232 9039800 SGTC_1048 3161-0300 24.5 µM 1.91769844956705 0.0402445055694848 no 200 0.0275746292268368 258 2165101 SGTC_428 3448-4153 16.5 µM 1.91246974927705 0.0406607360414674 no 201 0.0279079845531981 240 3834874 SGTC_2782 7736369 71.43 µM 1.91213107758347 0.0406878160222718 no 202 0.0279296918014697 298 2950836 YOL077C BRX1 SGTC_2775 cyproheptadine 69.59 µM 1.9090503468393 0.0409348220621241 no 203 0.0281277985823149 226 2913 A selective serotonin reuptake inhibitor. SGTC_2680 butyl paraben 22.24 µM 1.8992791959538 0.0417263077660006 no 204 0.0287638883581663 183 7184 An antifungal and steroid mimetic. SGTC_126 0417-1624 672.48 µM 1.89704339470413 0.041909144373768 no 205 0.0289111055219357 329 41912 YDL195W SEC31 SGTC_1103 duloxetine 36.1 µM 1.89623470645267 0.0419754358124629 no 206 0.0289645078950744 289 60835 A selective serotonin reuptake inhibitor. SGTC_17 0960-0276 49.807 µM 1.89328780949937 0.0422177234449362 no 207 0.0291598027136871 296 6821114 SGTC_2994 9053520 71.4286 µM 1.89227012187037 0.0423016579799226 no 208 0.0292274998428709 247 4647384 SGTC_2464 5717415 7.67 µM 1.89156270029868 0.0423600825952382 no 209 0.0292746347774995 246 5285744 SGTC_1396 3511-0007 98.6 µM 1.88765144666342 0.0426842848124929 no 210 0.0295363792896886 225 X1396 SGTC_51 1013-0126 23.419 µM 1.88582757722146 0.0428361489033333 no 211 0.0296590967225616 243 1627850 SGTC_1202 1988-0068 29.6 µM 1.88082373528717 0.0432550361063817 no 212 0.0299979501489573 270 2850480 SGTC_2687 chenodiol 100 µM 1.87458333687361 0.0437820677136474 no 213 0.0304250336675788 235 5702181 A cholesterol synthesis inhibitor. SGTC_21 0849-0113 22.993 µM 1.87222108603527 0.0439829178674414 no 214 0.0305880115198472 277 1560156 SGTC_1662 st014054 52 µM 1.8700369289818 0.0441692861228974 no 215 0.0307393449165009 193 2838777 SGTC_1516 st013856 110 µM 1.86352069847043 0.0447290838713175 no 216 0.031194521590762 226 5281404 A mutagen and neurotoxin. SGTC_3243 9134147 49.47 µM 1.86008889722378 0.0450261926324063 no 217 0.0314364748760535 179 24282180 SGTC_666 0272-0154 136 µM 1.85385341408036 0.0455700941547401 no 218 0.0318800671509677 315 6870312 SGTC_2677 mitomycin C 100 µM 1.84659096444873 0.0462102205488566 no 219 0.0324032223581283 199 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.84174140533134 0.0466416766853771 no 220 0.0327564922874313 310 5379071 SGTC_689 0833-0039 98 µM 1.8395339545778 0.0468391370726556 no 221 0.032918344239411 267 5374726 SGTC_2168 5727979 200 µM 1.83571007055744 0.0471827766224928 no 222 0.0332002738772712 239 695210 SGTC_2683 piperine 63.03 µM 1.8355704675034 0.0471953604134193 no 223 0.0332106041319519 217 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_721 1187-1332 279 µM 1.83544345431411 0.0472068116935962 no 224 0.0332200050702228 172 25730 SGTC_711 k292-0785 179 µM 1.83140342281454 0.0475722171546497 no 225 0.0335201754025822 280 4146315 SGTC_573 3702-0553 84.7 µM 1.83043924112359 0.0476597577408335 no 226 0.0335921421987942 261 1222756 SGTC_2008 4012253 172 µM 1.82904535834388 0.0477865400364872 no 227 0.0336964067794995 311 603940 SGTC_1714 st033236 13.627 µM 1.82408286023695 0.0482401035502467 no 228 0.0340697731577782 274 2916566 SGTC_645 0845-0943 5.41 µM 1.82158988914639 0.0484692528588754 no 229 0.0342586181121281 255 1885106 SGTC_1820 st053765 18.6 µM 1.82027226510279 0.0485907175798542 no 230 0.0343587764254347 262 3690829 SGTC_1483 3453-0561 55.9 µM 1.82001661895277 0.0486143123980553 no 231 0.0343782370435577 303 4546991 SGTC_613 3914-0030 117 µM 1.80970979982862 0.0495732313698719 no 232 0.035170401003899 75 1145395 SGTC_281 1672-3440 14.9 µM 1.80836156918624 0.0496997759881532 no 233 0.0352751225579482 268 6833000 SGTC_2386 9075165 157.42 µM 1.79945782043126 0.0505419632727528 no 234 0.035973145167679 231 16452277 SGTC_3053 9095903 49.47 µM 1.7973074732828 0.0507470551497858 no 235 0.0361434102273741 233 17174018 SGTC_1276 0871-0068 94.2 µM 1.79505622563331 0.0509624800712143 no 236 0.0363223710960438 260 3414906 SGTC_1046 2001-0062 216 µM 1.79151707890852 0.0513026168485063 no 237 0.0366051781999298 294 739778 SGTC_3050 9093513 49.47 µM 1.78934205663831 0.0515125460883666 no 238 0.0367798724084554 265 25236664 SGTC_2804 7954240 19.48 µM 1.78857086933664 0.0515871435333472 no 239 0.0368419763951945 317 828705 SGTC_296 1222-0039 74.9 µM 1.78144564071509 0.0522804411830671 no 240 0.0374198388934708 286 5984176 SGTC_1745 st081495 74 µM 1.7718431384696 0.0532264634386705 no 241 0.0382102997218136 386 13842402 YBL026W LSM2 SGTC_2767 sibutramine 71.45 µM 1.76880945896696 0.0535281410798279 no 242 0.0384628388506104 292 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.76757460712096 0.0536513255030365 no 243 0.0385660231133059 246 6857784 SGTC_1610 st001799 48.1 µM 1.76566943439244 0.0538418191064321 no 244 0.0387256618010484 233 621897 SGTC_2719 novobiocin 32.65 µM 1.75899906451849 0.0545129963177001 no 245 0.0392888337280742 192 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2560 caryophyllene 100 µM 1.74695371442714 0.0557417542442385 no 246 0.0403226836147978 337 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_1328 1441-0025 69.2 µM 1.74585220849961 0.0558552020217387 no 247 0.0404183180987752 260 4562601 SGTC_1574 spiramycin 23.7 µM 1.74437103877816 0.0560080397185782 no 248 0.0405472058359761 336 6419898 An antibiotic and protein synthesis inhibitor. SGTC_1763 st044482 94.5 µM 1.73967695045328 0.0564945893504987 no 249 0.0409578794319857 314 88505 SGTC_143 4032-1194 15.74 µM 1.7246822416066 0.0580711543378799 no 250 0.0422923765446929 420 1806963 SGTC_1814 st052110 31.539 µM 1.72187570972943 0.0583700421299108 no 251 0.0425460180039041 281 674163 SGTC_1643 st009866 20.2 µM 1.71522004784632 0.0590836815601632 no 252 0.0431524453013104 261 3156273 YOR207C RET1 SGTC_2469 5655019 90.81 µM 1.71506698850122 0.0591001731735132 no 253 0.0431664729255769 325 2788239 SGTC_1852 st056254 31.4 µM 1.71222963431739 0.0594065425412588 no 254 0.0434271791301488 289 442583 SGTC_770 0389-1121 67.2 µM 1.7113641243105 0.0595002452366219 no 255 0.0435069578009512 373 6753108 SGTC_54 0159-0055 9 µM 1.70852178241809 0.0598087807231887 no 256 0.0437697840762958 319 3319099 SGTC_178 4092-0806 87.505 µM 1.70463986750394 0.0602321846559047 no 257 0.0441308055559376 455 2169044 SGTC_1131 3454-3128 32.3 µM 1.70262859504564 0.0604524768049946 no 258 0.0443187976398395 385 710982 SGTC_521 r062-0005 13.8 µM 1.70206286641999 0.0605145538197641 no 259 0.0443717920003208 317 2832033 SGTC_3120 9124077 49.47 µM 1.70115421078894 0.0606143643510316 no 260 0.0444570167517477 278 18774327 YGL155W CDC43 SGTC_301 4119-0100 24.5 µM 1.69842284325697 0.0609151646311521 no 261 0.0447139918602151 386 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_1005 4092-0690 4.4 µM 1.6955735426851 0.0612301950869681 no 262 0.0449833358941363 314 1529343 SGTC_1455 4262-0120 131 µM 1.69373961875581 0.0614336337504014 no 263 0.0451573862118634 335 1529587 SGTC_233 rapamycin 362 pM 1.69176613736105 0.0616531430028725 no 264 0.0453452862452197 319 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1052 3253-3998 198 µM 1.69044293451771 0.0618006647662727 no 265 0.0454716234802204 375 5450317 SGTC_3057 9095946 49.47 µM 1.68810343745606 0.0620621656363469 no 266 0.0456956873614826 281 24540043 SGTC_963 1269-2853 151 µM 1.68398393316235 0.0625247271434156 no 267 0.0460923869274653 327 3668223 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.68320584188427 0.062612396688731 no 268 0.046167625157638 339 66535 A nucleotide analog. SGTC_2709 st078560 56 µM 1.67757867947362 0.0632492786126634 no 269 0.0467146889292019 310 17250903 SGTC_866 0495-0101 262 µM 1.67710306517785 0.0633033389534269 no 270 0.0467611647644605 300 635694 SGTC_75 0159-0059 199.013 µM 1.67708073684892 0.0633058777698822 no 271 0.046763347543977 313 5377270 SGTC_578 3460-0051 92 µM 1.67690478491128 0.0633258869522575 no 272 0.0467805511667036 375 2876744 SGTC_2630 antimycin a 100 µM 1.67579856862462 0.0634517982171392 no 273 0.0468888273058071 376 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_2912 7964298 10.93 µM 1.67578354652653 0.0634535093958054 no 274 0.0468902990466623 414 2975850 SGTC_1812 st052057 4.327 µM 1.67208625701564 0.0638757638262661 no 275 0.0472536571036811 346 3645418 SGTC_1343 1487-0095 224 µM 1.67165868120652 0.063924736403705 no 276 0.0472958231078477 304 4560101 YGL055W OLE1 SGTC_520 3584-0023 682 µM 1.66328894326844 0.0648892591238847 no 277 0.0481273054479232 344 1340790 SGTC_3140 9094243 49.47 µM 1.66268632216941 0.0649591384325458 no 278 0.0481876207718526 352 19291112 SGTC_1075 aripiprazole 15.2 µM 1.66046931316717 0.065216723320547 no 279 0.0484100381448872 403 60795 An atypical antipschotic. YIL048W NEO1 SGTC_1636 st007707 68.9 µM 1.6563077156729 0.065702380944773 no 280 0.0488297593905043 382 403051 SGTC_1768 st044301 37.178 µM 1.65479231725517 0.065879922360713 no 281 0.048983316472907 352 3931349 SGTC_266 formosanin C 406 nM 1.65391242858502 0.0659831790538961 no 282 0.049072653498674 383 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_2610 ononetin 44.17 µM 1.65168792339438 0.0662447884513427 no 283 0.0492990929070886 407 259632 SGTC_1841 st054148 70 µM 1.65029843557001 0.06640860410787 no 284 0.049440956055997 317 675442 SGTC_270 tamoxifen 5.46 µM 1.64533246094379 0.0669966393753529 no 285 0.0499506345943965 387 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_2396 5342950 42.78 µM 1.63577532761162 0.0681396510563293 no 286 0.050943308745551 408 1886677 SGTC_1835 st008666 49.2 µM 1.63542196540864 0.0681821991717303 no 287 0.0509803104364263 284 690455 SGTC_474 dl-dihydrosphingosine 5 µM 1.63424254491072 0.0683243608925491 no 288 0.0511039662248518 364 3058739 A sphingolipid protein kinase C inhibitor. SGTC_2772 vinpocetine 57.06 µM 1.63319099857621 0.0684513020487207 no 289 0.051214416272126 367 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_2990 9074105 71.4286 µM 1.62872337207068 0.0689926570622539 no 290 0.0516857963559715 314 6502001 SGTC_3015 9080845 49.47 µM 1.62370913657822 0.0696041698670093 no 291 0.0522189500725124 363 5296973 SGTC_2531 methyl deoxycholate 70.07 µM 1.61946642038305 0.0701248438939296 no 292 0.0526734729203066 353 16667744 Haematoxylin. SGTC_2186 6124449 200 µM 1.6178137680354 0.070328469383988 no 293 0.0528513691735741 331 3834182 YLR033W RSC58 SGTC_3182 9108849 49.47 µM 1.61613684258121 0.070535550019466 no 294 0.0530323650766272 411 17133045 SGTC_3079 9117512 49.47 µM 1.6157315037578 0.0705856748806228 no 295 0.0530761882684175 283 7185044 SGTC_2623 humulene 100 µM 1.6145496659813 0.0707319791606223 no 296 0.05320412654707 300 6187145 An anti-inflammatory. SGTC_2571 chrysanthemic acid 100 µM 1.61434408322025 0.0707574528231061 no 297 0.0532264065778638 335 2743 An insecticide. SGTC_3229 9132204 49.47 µM 1.61390933206984 0.0708113458473352 no 298 0.0532735470901436 269 17682924 SGTC_3258 9138477 49.47 µM 1.60605864597429 0.0717899753016232 no 299 0.0541305124867699 334 4970355 SGTC_201 4262-0159 12.803 µM 1.60180684393337 0.0723242976769249 no 300 0.0545991645894489 297 1341029 SGTC_2922 7999257 32.47 µM 1.60107316956546 0.0724168057616892 no 301 0.054680356997347 317 2988377 SGTC_2054 5233173 129 µM 1.59776178291865 0.0728354626591936 no 302 0.055048001466302 434 6889 SGTC_1076 itraconazole 331 nM 1.59418573126446 0.0732896593932926 no 303 0.0554472207125736 370 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_2496 diffractaic acid 79.83 µM 1.59220697889162 0.0735419115102643 no 304 0.0556691028248829 402 94870 An apoptosis inducer which activates caspases. SGTC_3355 9151058 44.0485 µM 1.59188823527179 0.0735826070786947 no 305 0.0557049097302348 357 17015728 SGTC_1778 st046819 58.9 µM 1.58898033315971 0.0739546687154358 no 306 0.0560324164508949 426 671715 SGTC_2384 9036245 200 µM 1.58573271937624 0.0743718932402552 no 307 0.0563999768105319 384 6462766 SGTC_893 0958-0369 48.9 µM 1.58528569012791 0.0744294640231037 no 308 0.0564507194100613 408 6819948 SGTC_1539 benzyladenosine 56 µM 1.58152100792448 0.0749156502152747 no 309 0.0568794797019198 340 92208 A nucleotide analog. SGTC_1737 st035557 69.7 µM 1.57814571655182 0.0753536052318746 no 310 0.0572660688061772 317 5716916 SGTC_892 0929-0076 29 µM 1.57734650402104 0.0754575908425219 no 311 0.0573579087222319 445 5751038 SGTC_1109 tnp00067 928.257 nM 1.57569723670689 0.0756725227950495 no 312 0.0575477972962373 352 676295 SGTC_3085 9117376 49.47 µM 1.5658093253388 0.0769709034493827 no 313 0.058696631217275 382 16480349 SGTC_2366 9070441 60.58 µM 1.56387640460106 0.0772266820979334 no 314 0.0589232983509612 400 6837235 SGTC_2923 7992654 58.14 µM 1.56378105920223 0.0772393156124793 no 315 0.0589344969355152 392 2985126 SGTC_2408 sulbentine 18.36 µM 1.55897100855892 0.077878699611169 no 316 0.0595016210548762 418 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1777 st045864 34.765 µM 1.55672491648172 0.0781786373557368 no 317 0.0597679051485307 394 4691462 SGTC_943 3253-1379 105 µM 1.54961530912878 0.0791338140387921 no 318 0.0606169381345178 386 668464 SGTC_1123 mangostin 811.285 nM 1.54869767257483 0.0792577397875645 no 319 0.0607272068219886 431 5281650 An antioxidant. SGTC_3273 9137859 49.47 µM 1.54718737860232 0.0794620230570745 no 320 0.0609090342724292 332 2377234 SGTC_2869 9037858 32.47 µM 1.54582607781124 0.0796464946474037 no 321 0.0610732886041413 327 27187042 SGTC_750 4073-0104 132 µM 1.54453663422491 0.0798215273995695 no 322 0.0612291917457533 311 22330957 SGTC_202 3594-0513 34.79 µM 1.53863762802259 0.080625986869257 no 323 0.0619463935063871 343 708429 SGTC_329 k048-0121 21.3 µM 1.53797225397703 0.0807171082097555 no 324 0.0620276995054709 373 6832902 SGTC_1419 3993-2473 62.6 µM 1.536848598217 0.0808711666316717 no 325 0.0621651946837778 390 704026 SGTC_1179 1021-1431 9.29 µM 1.53605803133316 0.0809796899833383 no 326 0.0622620741287877 490 2840958 SGTC_1338 1486-1223 76 µM 1.5358830836801 0.0810037203897788 no 327 0.0622835288665471 421 3444526 SGTC_596 1155-0152 116 µM 1.52952141172301 0.0818812057357116 no 328 0.0630676175730117 466 280313 SGTC_923 1900-2434 73.3 µM 1.52919394518511 0.0819265673290973 no 329 0.0631081855858095 397 5910570 SGTC_2622 2-methoxyxanthone 59.94 µM 1.52642662775753 0.0823106604673659 no 330 0.0634518251910609 417 71034 A hepatoprotective. SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 1.52472435322003 0.0825476024198668 no 331 0.0636639324186841 370 2374 Ca(2+)-ATPase inhibitor. SGTC_2305 7443522 69.23 µM 1.52366326430536 0.0826955564038609 no 332 0.0637964253218978 421 5415886 SGTC_3198 9112019 49.47 µM 1.52082249533694 0.0830926441046484 no 333 0.0641521938349653 393 45595555 SGTC_1108 betulinic acid 729.144 nM 1.51856468190069 0.083409266664056 no 334 0.0644360533814323 405 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_668 1682-0499 62.6 µM 1.51790362554618 0.0835021407475437 no 335 0.0645193479305655 489 682214 SGTC_468 gf-109203x 121 µM 1.51654493764394 0.0836932714714061 no 336 0.0646908081943784 261 2396 A protein kinase C inhibitor. SGTC_1747 st037496 66.6 µM 1.51080720267055 0.0845040416830915 no 337 0.0654187895393348 457 723305 SGTC_2868 9035608 32.47 µM 1.51023117534532 0.0845857615288032 no 338 0.0654922232037367 446 6462614 SGTC_1303 1160-0052 261 µM 1.50990799884909 0.0846316358832777 no 339 0.0655334506825433 408 3562476 SGTC_1848 st056003 16.4 µM 1.5096752677889 0.0846646832177234 no 340 0.0655631525410687 417 146492 SGTC_838 0109-0203 71.4 µM 1.50758128148008 0.0849624603936878 no 341 0.0658308632404458 409 759422 SGTC_3196 9111891 49.47 µM 1.50613785390068 0.0851681809339414 no 342 0.0660158944528295 369 18891510 SGTC_1944 st076371 56.9 µM 1.50199622196417 0.085760527427675 no 343 0.0665490422711132 410 24208455 SGTC_3338 9144300 39.5675 µM 1.50191304479848 0.0857724551421727 no 344 0.0665597836177466 424 4901274 SGTC_551 k048-0028 34.9 µM 1.497993248858 0.0863359681830304 no 345 0.0670675022502164 454 6836383 SGTC_1505 k297-0037 20.6 µM 1.4973036022498 0.0864353980878609 no 346 0.0671571390002492 441 4089396 SGTC_1909 st060837 51.5 µM 1.49126105126604 0.0873102479688992 no 347 0.0679464852386055 453 678937 SGTC_3268 9137683 49.47 µM 1.48849269180688 0.087713256375777 no 348 0.0683105040262958 356 1953228 SGTC_3092 9117248 49.47 µM 1.4870062454789 0.0879302200260576 no 349 0.0685065807192475 407 17141857 SGTC_796 1234-0020 70.7 µM 1.4841101205292 0.0883540913208572 no 350 0.068889854370898 448 46495034 SGTC_2540 epiandrosterone 100 µM 1.48261137636577 0.0885740416315684 no 351 0.0690888464133335 579 441302 A steroid. SGTC_1661 st013063 9.66 µM 1.47801164984356 0.0892516276393952 no 352 0.0697023300294022 476 721395 SGTC_2095 5432005 200 µM 1.47381424224289 0.0898733066780866 no 353 0.0702658062850972 390 783734 SGTC_2984 9022109 38.96 µM 1.46900381058554 0.0905897320477182 no 354 0.0709158778322157 354 6459207 SGTC_3239 9133757 49.47 µM 1.46857673357747 0.0906535416309657 no 355 0.0709738146685063 387 17036923 SGTC_12 0849-0099 9.267 µM 1.46558590278861 0.091101336817897 no 356 0.0713805670425894 407 6071388 SGTC_278 4092-0821 23.9 µM 1.46025404889171 0.0919037018853953 no 357 0.0721101329203162 424 877900 SGTC_1406 3909-7906 11.9 µM 1.45495431788883 0.0927064076366427 no 358 0.0728409543511774 442 X1406 SGTC_1711 st032263 62.8 µM 1.45313513856186 0.0929831354355846 no 359 0.0730931182690337 431 3958979 SGTC_199 4063-0024 41.6 µM 1.45123141535056 0.0932733771336 no 360 0.073357715908861 424 306215 SGTC_35 0133-0054 64.071 µM 1.45056561114779 0.0933750434924684 no 361 0.0734504284616844 429 99677 SGTC_354 2783-3500 4.88 µM 1.44947520408725 0.0935417222469112 no 362 0.0736024600452242 453 6740761 SGTC_2086 5274770 176.623 µM 1.44429861056544 0.0943360105565716 no 363 0.0743274982314138 437 689278 SGTC_793 0488-0545 106 µM 1.44249046732414 0.0946146180378274 no 364 0.0745820294464955 455 292548 SGTC_1879 gemcitabine 100 µM 1.44117294597514 0.0948180097844927 no 365 0.0747679147236882 442 60750 A nucleoside analog which inhibits DNA replication. SGTC_1156 4092-0367 4.88 µM 1.43979322127751 0.095031349308219 no 366 0.0749629548003392 474 1357585 SGTC_1775 st081588 35.1725 µM 1.43869678542236 0.0952011373491454 no 367 0.0751182252599613 501 1426443 YGL099W LSG1 SGTC_191 3914-0123 66.505 µM 1.43580776988124 0.0956495840016284 no 368 0.075528524136979 316 3144412 SGTC_879 0831-1030 162 µM 1.43505560127752 0.095766593778797 no 369 0.075635627024246 534 1549252 SGTC_2949 9072542 2.23 µM 1.43309069835578 0.096072757200536 no 370 0.0759159596526355 506 16457352 SGTC_1931 st074438 57.1 µM 1.43086312789582 0.0964207181515227 no 371 0.0762347231801529 428 2787313 SGTC_1608 st001473 40.5 µM 1.43079723303297 0.0964310254401819 no 372 0.0762441681702172 456 7292267 SGTC_1762 st045503 25.4615 µM 1.42786837218634 0.0968899765829322 no 373 0.0766648742937815 469 4645554 SGTC_1293 1000-1278 195 µM 1.4271447870237 0.0970036086935025 no 374 0.0767690826396084 476 678847 SGTC_359 0081-0058 15.9 µM 1.42507759463023 0.097328780342273 no 375 0.0770673862278799 455 3494159 SGTC_2904 7225135 42.03 µM 1.42376663184565 0.0975354102037724 no 376 0.0772570190066061 472 4446116 SGTC_3134 9127454 49.47 µM 1.41983262902264 0.0981574064384376 no 377 0.077828206632538 431 24262820 SGTC_132 0417-1715 25.805 µM 1.41817496596011 0.0984203641675329 no 378 0.0780698444033577 485 6769098 SGTC_1667 st014849 34.6 µM 1.416407677347 0.0987012797079146 no 379 0.0783280887061477 477 5348460 SGTC_2 0422-0095 29 µM 1.41416192660393 0.0990590942306113 no 380 0.0786571820048383 360 6790840 SGTC_2734 clemastine 41.6 µM 1.41062991041841 0.099623766955458 no 381 0.0791768837150934 299 26987 Clemastine is a selective histamine H1 antagonist. SGTC_1933 st074711 15.9 µM 1.40937147977498 0.0998255228063452 no 382 0.0793626763627761 515 17250958 SGTC_1444 4112-3581 28 µM 1.40922950241548 0.0998483038184013 no 383 0.0793836583671399 466 2877249 SGTC_2293 7624732 200 µM 1.40784791285677 0.100070185404645 no 384 0.0795880546901565 442 894453 SGTC_1171 0368-0077 21.4 µM 1.4067741777656 0.10024287439718 no 385 0.0797471809402899 432 3239779 SGTC_2089 5281248 129.67 µM 1.40509934797908 0.100512671652333 no 386 0.0799958689926923 480 2737878 SGTC_1318 1280-3875 124 µM 1.40449206956889 0.100610628497652 no 387 0.0800861857793448 508 373245 SGTC_1802 st050112 57.9 µM 1.40279616392103 0.100884554751412 no 388 0.0803388156264436 486 4662563 SGTC_1609 st001574 46.4 µM 1.39959456648527 0.101403165012234 no 389 0.0808173809961683 486 3960012 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.39689395595413 0.10184213073818 no 390 0.081222731201948 366 279621 SGTC_2154 5570129 200 µM 1.39649322304274 0.10190738479523 no 391 0.0812830099817074 519 673366 SGTC_230 MPP+ 141.667 µM 1.39399506079846 0.102314863726311 no 392 0.0816595480840046 470 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_2424 5537928 59.2 µM 1.39153107375614 0.102717927786889 no 393 0.082032221803283 528 5382802 SGTC_1227 3909-8010 46.6 µM 1.39135201831065 0.102747262958153 no 394 0.0820593534870926 458 15982272 SGTC_3153 9100258 49.47 µM 1.38918601173255 0.103102608475595 no 395 0.0823880970972843 462 25236848 SGTC_667 1498-1044 59 µM 1.38724210338215 0.103422276757306 no 396 0.0826839754256579 485 6739982 SGTC_2673 kobusone 100 µM 1.38349800129158 0.104040006095137 no 397 0.0832561098765544 450 6710676 An epoxy ketone and protein crosslinker. SGTC_1408 3909-7976 48.8 µM 1.38316157223923 0.104095643337775 no 398 0.0833076648203359 536 24152374 SGTC_1479 0549-0158 134 µM 1.37844940086491 0.104877190787436 no 399 0.0840322899830287 542 5440202 SGTC_2987 9018338 71.43 µM 1.37831030983674 0.104900324410654 no 400 0.0840537507087146 500 5055682 SGTC_2088 5278280 127.392 µM 1.37638064116746 0.105221648179963 no 401 0.0843519091179103 530 791502 SGTC_2739 tacrine 100.86 µM 1.37634360936892 0.105227821582851 no 402 0.0843576387543506 449 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2241 6772625 37.8075 µM 1.37613702263196 0.105262265528292 no 403 0.0843896076405209 476 2285411 SGTC_3007 9078383 71.4286 µM 1.37527640077399 0.10540584369912 no 404 0.0845228849824395 482 6496995 SGTC_1423 4048-0112 5.59 µM 1.3716161643958 0.106018066048327 no 405 0.0850914795382937 495 X1423 SGTC_680 0417-1641 114 µM 1.37100202768087 0.106121039650416 no 406 0.0851871619722416 451 2835990 SGTC_2822 7994718 71.43 µM 1.36991489899561 0.106303497940445 no 407 0.0853567341351336 423 1018011 SGTC_371 0195-0006 7.36 µM 1.36848335585811 0.106544106494345 no 408 0.0855804141833856 417 3928593 SGTC_1713 st033146 12.748 µM 1.36717830500925 0.106763797035541 no 409 0.0857847118789113 511 674619 SGTC_655 k060-0012 42 µM 1.36408351045121 0.107286076974027 no 410 0.0862706419506092 511 5994525 SGTC_3274 9138298 49.47 µM 1.36375872342491 0.107340994900559 no 411 0.0863217576013876 528 17015756 SGTC_2733 amorolfine 100 µM 1.36333900690909 0.107411994375157 no 412 0.0863878469927559 368 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_2268 7933382 153.85 µM 1.36312903510412 0.107447526020346 no 413 0.0864209237629776 580 935025 YOR257W CDC31 SGTC_1664 st014217 9.02 µM 1.35925230714254 0.108105072642844 no 414 0.0870333256512874 522 3982782 SGTC_1569 carminic acid 40.6 µM 1.3591461752624 0.108123114726245 no 415 0.0870501366381326 515 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_148 3253-0744 288.01 µM 1.35140897089781 0.109444259754896 no 416 0.0882822308502989 484 6893655 SGTC_1424 4048-1941 275 µM 1.35028635299389 0.109636908337037 no 417 0.0884620740679364 538 X1424 SGTC_2563 tomatine 8.54 µM 1.34775500913724 0.110072196678096 no 418 0.0888685964126625 591 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_2043 5101342 149 µM 1.34770655101278 0.110080541584863 no 419 0.0888763921130624 520 678451 SGTC_1678 st019265 80.2 µM 1.34649226715979 0.11028979993592 no 420 0.0890719062851812 553 5367020 SGTC_1236 0330-0013 258 µM 1.34343140187938 0.110818546379656 no 421 0.0895661622551221 494 4617066 SGTC_3163 9099914 49.47 µM 1.343292214849 0.110842633216642 no 422 0.0895886859883717 440 16268368 SGTC_1078 idebenone 36.1 µM 1.34262614131247 0.110957951660494 no 423 0.0896965306511659 583 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_3172 9105863 49.47 µM 1.33811283481928 0.111741612520513 no 424 0.0904298287273233 418 2348785 SGTC_1288 0973-0013 65.5 µM 1.33705815866178 0.111925308843093 no 425 0.0906018267639688 545 4315430 SGTC_1786 berberine 21.6 µM 1.33502203784685 0.112280557169651 no 426 0.0909345668775519 529 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_367 0335-0881 7.1 µM 1.3288573832645 0.113361034484806 no 427 0.0919475130655594 568 23828853 SGTC_2235 salicylic acid 500 µM 1.32413156030827 0.114194335196317 no 428 0.0927296778007622 505 338 A COX inhibitor and kinase inhibitor. SGTC_1863 st057641 20.1 µM 1.31933580277287 0.115044417909328 no 429 0.0935284367258509 561 3921635 SGTC_846 0335-0850 148 µM 1.31900939063341 0.115102439957354 no 430 0.0935829865295925 486 6819598 SGTC_880 0833-0487 87.2 µM 1.31896150091102 0.115110954441548 no 431 0.0935909918076508 527 76075 SGTC_1800 st050079 29.0735 µM 1.31804878770954 0.115273314579395 no 432 0.093743658228954 700 3645560 SGTC_3331 9141060 1.957 µM 1.31682192006763 0.115491815194265 no 433 0.0939491617411319 500 4906567 YPR165W RHO1 SGTC_2115 tiliquinol 12.7705 µM 1.31402882784405 0.115990351864049 no 434 0.0944182515930054 495 71208 A bioactive hydroxyquinoline. SGTC_405 ebelactone b 50 µM 1.31184521711728 0.116381165367752 no 435 0.0947861823942592 552 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2558 carylophyllene oxide 100 µM 1.30854047859361 0.116974408849939 no 436 0.0953450271838728 582 6708694 An oxygenated terpenoid and antifungal agent. SGTC_2171 5739187 198.077 µM 1.30625698595105 0.117385575435535 no 437 0.0957325897547324 466 2262761 SGTC_1957 st077035 62.4 µM 1.30192242052062 0.118168871998909 no 438 0.0964714536100486 533 705593 SGTC_857 0438-0306 1.35 µM 1.30170089012118 0.118209003661416 no 439 0.0965093275963382 545 4686136 SGTC_1669 st015249 58.4 µM 1.29992415399192 0.118531219517933 no 440 0.0968134828500171 515 722793 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 1.29817969949135 0.118848184418411 no 441 0.0971127961283282 582 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1964 st076914 61 µM 1.29707254926818 0.119049662323333 no 442 0.0973031127944935 518 24208661 SGTC_738 1315-0003 72.4 µM 1.29032530121597 0.120282732097054 no 443 0.0984688678761657 582 6251474 SGTC_741 4582-0002 126 µM 1.289692801725 0.120398781908127 no 444 0.0985786699281456 540 2912688 SGTC_361 000s-0510 1.45 µM 1.28491781459428 0.121277432823359 no 445 0.0994105024882317 576 660 SGTC_1642 st009582 77.7 µM 1.28467435888549 0.121322351893457 no 446 0.0994530510480675 514 6739311 SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 1.28454065582445 0.121347025903614 no 447 0.0994764238870746 502 364106 SGTC_1591 genipin 88.4 µM 1.28442687653088 0.121368025893833 no 448 0.0994963169832339 511 442424 A DNA cross-linking agent. SGTC_429 1112-0049 25.5 µM 1.28284845909035 0.121659614505633 no 449 0.0997725864469031 529 2836170 SGTC_2704 st078022 71.1 µM 1.282302668365 0.121760555494765 no 450 0.0998682461420916 549 54697681 SGTC_2344 7990960 76.95 µM 1.28186469135278 0.121841599477535 no 451 0.0999450579683734 517 140813 SGTC_537 1334-0398 209 µM 1.27851307487957 0.122463042773037 no 452 0.100534288802469 583 5846986 SGTC_824 1304-0008 100 µM 1.27794710695942 0.122568201395595 no 453 0.100634038377059 609 768245 SGTC_2797 7859098 81.82 µM 1.27721728256751 0.122703898566477 no 454 0.100762773540155 571 972681 SGTC_675 1309-0189 238 µM 1.2766482834456 0.122809766370781 no 455 0.100863223701759 564 4246530 SGTC_798 1287-0182 476 µM 1.27661136797458 0.122816637064234 no 456 0.100869743219081 619 1649755 SGTC_2556 citropten 84.59 µM 1.27383275322627 0.123334565724992 no 457 0.101361347362866 615 2775 A potential DNA crosslinker. SGTC_409 arachidonic acid 100 µM 1.27332709041906 0.123428984681402 no 458 0.101450998745547 576 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_3321 9137793 26.8275 µM 1.27144333833697 0.123781170441336 no 459 0.101785486525511 593 4904192 SGTC_149 3970-0822 46.1 µM 1.26842437998316 0.124347060113126 no 460 0.102323219889359 722 3114250 YBL034C STU1 SGTC_1063 disulfiram 1.84 µM 1.2651992238143 0.124953596751559 no 461 0.102899960323268 564 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_1578 josamycin 24.2 µM 1.26469611913831 0.125048398798059 no 462 0.102990140841458 521 5282165 A P450 substrate. SGTC_136 0097-0015 404.482 µM 1.26270970867742 0.125423196853352 no 463 0.103346761821793 619 4861337 SGTC_2049 5262831 67.185 µM 1.26195767298402 0.125565296163902 no 464 0.103482008735018 576 763417 SGTC_2234 tolnaftate 200 µM 1.25580161511765 0.126732725226798 no 465 0.104593952948687 495 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_3356 9151811 4.48 µM 1.25397665429966 0.127080256891151 no 466 0.104925245548599 587 1859254 YPR165W RHO1 SGTC_1016 4226-1401 38 µM 1.25110663682601 0.127628141794614 no 467 0.105447787239688 593 2901613 SGTC_2433 5607874 27.82 µM 1.24812448762287 0.128199169951574 no 468 0.105992735947897 577 2252428 SGTC_1437 4092-1038 11.6 µM 1.24608102103268 0.128591480187456 no 469 0.106367325866436 608 3977136 SGTC_120 rhodamine 6G 52.259 µM 1.24539450390122 0.128723466374549 no 470 0.106493386293378 690 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_1327 1436-0082 2.18 µM 1.24457092159646 0.128881927969008 no 471 0.10664475732629 578 15992205 SGTC_797 k781-0471 270 µM 1.24311490681528 0.12916240385512 no 472 0.106912746691622 605 23738129 SGTC_2725 haloperidol 53.21 µM 1.24065255403717 0.129637695571059 no 473 0.107367064326436 585 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_416 estradiol valerate 100 µM 1.24004168336955 0.129755795218489 no 474 0.107479988464785 574 13791 A steroid. SGTC_3112 9123419 49.47 µM 1.23687201990881 0.130369782518645 no 475 0.108067299587446 614 17015854 SGTC_661 1304-0007 33.6 µM 1.23566827743438 0.130603482047303 no 476 0.108290946890218 575 3117130 SGTC_601 0986-0029 62.9 µM 1.2321635568189 0.131285551712022 no 477 0.10894399681117 628 24747981 SGTC_2017 5132927 60.65 µM 1.22551635437836 0.132585941756437 no 478 0.110190365990528 592 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_68 0986-0284 82.829 µM 1.22481202806429 0.132724247013541 no 479 0.110323026007562 531 423278 YIL048W NEO1 SGTC_2192 5915882 198.485 µM 1.22378678072517 0.132925747568703 no 480 0.11051633620548 545 2876149 SGTC_2511 berberine 10.47 µM 1.22155100960321 0.133365892798147 no 481 0.110938732273983 597 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2179 6298986 200 µM 1.22099529975136 0.133475448048158 no 482 0.111043899711471 576 738374 SGTC_96 0929-0093 37.281 µM 1.22063046141764 0.133547407640655 no 483 0.111112983753161 562 6991579 SGTC_1833 st055984 71 µM 1.21996018086989 0.133679681240434 no 484 0.111239985074833 589 676288 SGTC_2170 morpholine 200 µM 1.21906505162607 0.133856467054718 no 485 0.111409751595773 615 121171 Reacts with secondary amines. SGTC_2070 5230947 200 µM 1.21753018375154 0.134159973517416 no 486 0.111701279740581 623 2835538 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 1.21548405015753 0.134565312874489 no 487 0.112090764216197 641 165521 SGTC_2470 5664817 21.68 µM 1.21511170960651 0.134639163899334 no 488 0.11216174405643 596 2859561 SGTC_854 0422-0053 192 µM 1.21460646401694 0.134739420141558 no 489 0.112258111150786 592 3596728 SGTC_2900 5328528 85.29 µM 1.21392884314859 0.134873961339081 no 490 0.112387448803662 652 795359 SGTC_2728 chlorpromazine 9.18 µM 1.21199978167434 0.135257479805769 no 491 0.112756232103835 505 2726 A thorazine and dopamine antagonist. SGTC_2333 9017922 200 µM 1.21150363804849 0.135356239320421 no 492 0.112851220602869 622 3163164 SGTC_3031 9088762 49.47 µM 1.21002401528098 0.135651058009265 no 493 0.113134838935397 629 205253 SGTC_1413 3910-0535 34.4 µM 1.20861452098093 0.135932312248346 no 494 0.113405487515108 639 2876951 SGTC_215 1287-0124 461.5 µM 1.20789989782488 0.136075062478952 no 495 0.113542884451677 545 5560863 SGTC_2231 micatex 6.853 µM 1.20789485233499 0.136076070710267 no 496 0.113543854943974 579 20737 An antifungal of unknown mechanism. SGTC_1888 azatryptophan 97.5 µM 1.20662068035142 0.13633084995423 no 497 0.113789129363278 564 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_399 oxolinic acid 75 µM 1.2029663517578 0.137063366963338 no 498 0.114494670917443 599 4628 A DNA gyrase inhibitor. SGTC_2654 protoveratrine a 100 µM 1.20118037755723 0.137422345373395 no 499 0.11484061967166 602 5702278 A heart drug and vasodilator. SGTC_2911 7942208 15.64 µM 1.19978922368368 0.137702409817151 no 500 0.115110605219414 574 1243384 SGTC_1348 1493-0373 93.8 µM 1.19900251736494 0.13786096033309 no 501 0.115263483379409 613 3010129 SGTC_1999 st074831 12.5 µM 1.19851864808123 0.137958539783935 no 502 0.115357583826611 646 17112523 SGTC_1914 st062367 72.6 µM 1.19782785405353 0.138097930315623 no 503 0.115492020546794 593 978205 SGTC_63 0099-0242 26.702 µM 1.19750870802295 0.138162361001985 no 504 0.115554167735758 687 3898502 YLR359W ADE13 SGTC_2111 5486399 200 µM 1.19443748352168 0.138783441796141 no 505 0.116153440843953 689 689674 SGTC_2780 5215298 71.43 µM 1.19369396376789 0.138934086111062 no 506 0.116298851279613 673 2834131 SGTC_1044 1222-0021 1.78 µM 1.19228766215548 0.139219320802523 no 507 0.116574235291154 630 4306703 SGTC_2596 sinensetin 100 µM 1.18946898911364 0.139792220406596 no 508 0.117127583520403 602 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2706 st078239 82.5 µM 1.18920382458085 0.139846197858127 no 509 0.117179734941719 631 15434492 SGTC_2113 5491891 107.031 µM 1.1887654498229 0.139935465414726 no 510 0.117265988679594 631 789979 SGTC_2251 lansoprazole 556 µM 1.18789169682394 0.140113505830649 no 511 0.117438040688188 484 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1771 st048882 4.1505 µM 1.18737700494853 0.140218454095731 no 512 0.117539473052718 632 4580403 SGTC_1512 0259-0544 12.2 µM 1.18727857170676 0.140238531209989 no 513 0.117558878744199 682 18476 SGTC_3102 9121669 49.47 µM 1.18513290211642 0.140676661786461 no 514 0.117982451995548 588 41905072 SGTC_3023 9089636 49.47 µM 1.18416372096998 0.140874865972914 no 515 0.118174130058189 676 17249241 SGTC_2005 4024620 188 µM 1.18364479203144 0.14098106833497 no 516 0.118276850771162 629 236743 SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.18257694692312 0.141199780964271 no 517 0.11848842667138 615 6710655 SGTC_2051 5263410 176 µM 1.1806778225874 0.14158932166146 no 518 0.118865367443178 659 227584 SGTC_2267 7931562 200 µM 1.17601783579301 0.142548242032418 no 519 0.119793874432525 570 934880 SGTC_2011 4012611 177 µM 1.17471807653001 0.142816484749265 no 520 0.120053762472152 643 2049887 SGTC_1565 sinapyl alcohol 95.1 µM 1.17461568366022 0.142837630952198 no 521 0.12007425289106 597 5280507 A phenol propionate derived from cinnamic acid. SGTC_307 1501-1223 22.3 µM 1.1740105170454 0.142962653338503 no 522 0.12019540655142 631 2830329 SGTC_691 1548-0686 185 µM 1.16919862389701 0.143959381697573 no 523 0.121161807745866 667 46495133 SGTC_1801 st050089 28.441 µM 1.16875442921574 0.144051627253815 no 524 0.121251292775771 748 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_2456 5770359 74.46 µM 1.16859506925813 0.144084731122852 no 525 0.121283407886553 664 3118787 SGTC_3147 9097027 49.47 µM 1.16759578359715 0.144292429823938 no 526 0.121484925885872 677 25236841 SGTC_1221 2958-7315 257 µM 1.16676203098533 0.144465877310224 no 527 0.121653242178964 634 4562705 SGTC_1915 st067105 30.6 µM 1.16222416854987 0.145412361892865 no 528 0.122572209932912 657 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_1400 3771-8998 51.5 µM 1.16187810011536 0.14548471389487 no 529 0.122642491994181 593 670767 SGTC_720 r052-1644 49.9 µM 1.16147331164552 0.14556937312248 no 530 0.12272473520807 570 1422863 YOR257W CDC31 SGTC_549 1661-1316 519 µM 1.15846912041413 0.146198717930635 no 531 0.123336323087162 671 2857282 SGTC_2153 5569715 200 µM 1.14838396501396 0.148324794745536 no 532 0.125405045143554 647 2054701 SGTC_1250 0485-0349 40.2 µM 1.14710097151836 0.148596741258254 no 533 0.125669946203281 618 6842794 YDL195W SEC31 SGTC_3220 9131269 49.47 µM 1.14618141466808 0.148791857784604 no 534 0.12586004812046 646 17722206 SGTC_2979 9012552 45.46 µM 1.141442445982 0.149800111721982 no 535 0.126842924843678 609 17100905 SGTC_2321 7390090 138.78 µM 1.1410905336006 0.149875165278754 no 536 0.1269161251127 588 649046 SGTC_2227 7312221 64.1025 µM 1.13836443681797 0.150457418787361 no 537 0.127484168785366 659 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_2281 7943571 200 µM 1.13528052413086 0.151117910690371 no 538 0.128128899884504 725 1244024 SGTC_2726 cimetidine 79.27 µM 1.13443158294161 0.151300069382779 no 539 0.128306778655708 596 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1864 st057645 30.4 µM 1.13349243068048 0.151501754889307 no 540 0.128503759045454 650 688666 SGTC_1054 3429-0080 167 µM 1.1319440889499 0.151834655594205 no 541 0.128828970614751 695 1162877 SGTC_889 0919-1524 82.7 µM 1.13148726828054 0.151932966954412 no 542 0.128925029576335 647 3905452 SGTC_1614 st002383 48.6 µM 1.13098358603151 0.152041412296372 no 543 0.129031000026679 690 1947235 SGTC_1564 D-Arginine 115 µM 1.1305684207099 0.152130838137397 no 544 0.129118392668561 656 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_1780 st038448 24.544 µM 1.12804933039021 0.152674194322975 no 545 0.129649543165323 675 728868 YDL195W SEC31 SGTC_2040 5100729 123 µM 1.12180102398487 0.154027475543599 no 546 0.130973525378627 700 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_1960 st011366 51.8 µM 1.12070193824989 0.154266337868601 no 547 0.131207378446008 670 3972846 SGTC_1916 st067606 49.2 µM 1.12048492187606 0.15431353059092 no 548 0.131253587209019 727 19590279 SGTC_813 k007-0158 173 µM 1.11906297245633 0.154622986133195 no 549 0.131556637473682 770 6523916 SGTC_232 clozapine 119 µM 1.11759242444651 0.154943449156011 no 550 0.131870552858634 679 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1581 himbacine 57.9 µM 1.11739143642637 0.154987282678686 no 551 0.131913497533873 715 5281825 An alkaloid muscarinic receptor antagonist. SGTC_1817 st052116 64.4 µM 1.11664245710934 0.155150699859372 no 552 0.132073615272642 671 4361398 SGTC_3081 9117243 49.47 µM 1.11641460920669 0.155200435755194 no 553 0.132122351458846 667 45595589 SGTC_275 trichlorophene 5.69 µM 1.11574113312908 0.155347507348955 no 554 0.132266479061954 823 62616 SGTC_678 1218-2179 85.9 µM 1.11552789653422 0.155394092452037 no 555 0.132312135453317 634 6820081 YOR116C RPO31 SGTC_3022 9087993 49.47 µM 1.1127107621383 0.15601040790315 no 556 0.132916335944677 668 17173644 SGTC_529 4076-0302 30.3 µM 1.11093531192163 0.156399656548732 no 557 0.133298097257554 694 5816522 SGTC_3316 9136639 10.545 µM 1.10850764900421 0.156932930232669 no 558 0.133821318789018 689 4903665 SGTC_3019 9081971 49.47 µM 1.10729564396075 0.157199613043226 no 559 0.134083063535675 724 16451803 SGTC_2732 terfenadine 20 µM 1.10721009398347 0.157218448234448 no 560 0.134101552198865 649 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_1030 k029-0042 36.7 µM 1.10686826996136 0.157293721050824 no 561 0.13417544309599 741 6080581 SGTC_1385 3091-4834 14.1 µM 1.10673500901017 0.157323072764683 no 562 0.13420425722269 649 4072814 SGTC_1367 1812-0510 76.9 µM 1.10292373677855 0.158164057776545 no 563 0.135030142570828 685 1142582 YDR527W RBA50 SGTC_1111 tnp00062 510.699 nM 1.10199530825583 0.158369368393731 no 564 0.135231855666937 721 676306 SGTC_1020 4335-0961 93.3 µM 1.10158425127574 0.15846032443682 no 565 0.135321229053776 660 669075 SGTC_2033 5192550 145 µM 1.09819759516291 0.159211005742058 no 566 0.136059108059088 681 182073 SGTC_795 0685-0265 78 µM 1.09623317326319 0.159647502289146 no 567 0.136488372860967 720 302754 SGTC_3082 9117008 49.47 µM 1.09507327988751 0.159905599142553 no 568 0.136742266857629 710 41448529 SGTC_1124 fisetin 1.16336 µM 1.09238240642059 0.160505416631497 no 569 0.137332526408761 653 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_534 k292-0788 63.4 µM 1.09075547293005 0.160868785380788 no 570 0.137690247046651 798 4146317 SGTC_7 0192-1582 4.227 µM 1.09020998246482 0.160990738504442 no 571 0.137810328525837 817 252616 SGTC_2062 5245942 200 µM 1.090017845027 0.161033708269818 no 572 0.137852641689381 741 1376160 SGTC_966 1300-0360 30.2 µM 1.08923216948038 0.161209495230268 no 573 0.138025758065047 702 70588 SGTC_1900 st060200 72.8 µM 1.08830061427545 0.161418083440139 no 574 0.138231209729809 723 688945 SGTC_1232 0279-0259 161 µM 1.08622377550558 0.161883749919608 no 575 0.138690000447676 724 1560000 SGTC_2603 homopterocarpin 100 µM 1.08524127204032 0.162104350416709 no 576 0.138907404537755 722 101795 A weak amylase inhibitor. SGTC_1441 4106-0040 13 µM 1.08432000174053 0.162311380058451 no 577 0.139111469918485 718 2904180 SGTC_226 1,3-diallylurea 8.28947 mM 1.08427413867413 0.162321690990914 no 578 0.139121634116408 671 74537 YKL182W FAS1 SGTC_89 0302-0250 142.109 µM 1.08368155116782 0.162454954831647 no 579 0.139253009143747 764 4203518 YLR208W SEC13 SGTC_2072 5231554 129 µM 1.0832134813026 0.162560266881316 no 580 0.13935683860708 745 789545 SGTC_632 0781-2353 4.65 µM 1.08230110013342 0.162765673138518 no 581 0.139559378657914 744 6811515 YHR007C ERG11 SGTC_2969 9091408 28.7 µM 1.08195324266944 0.162844031436521 no 582 0.139636652435565 691 4286311 SGTC_555 4296-0685 37 µM 1.07847938058542 0.163627898286929 no 583 0.140409939355823 745 2908540 YHR072W ERG7 SGTC_378 3970-0959 8.33 µM 1.07776782806287 0.163788759831824 no 584 0.140568690119987 731 6615653 SGTC_2755 lomerizine 42.69 µM 1.07703905960403 0.163953619766278 no 585 0.140731408088354 755 3949 A calcium channel blocker. SGTC_3325 9138760 55.175 µM 1.07449421440797 0.164530151548208 no 586 0.141300618228632 710 43844959 SGTC_1839 st053978 48 µM 1.07402951340779 0.16463557072941 no 587 0.141404727015547 721 3788398 SGTC_1761 st044296 37 µM 1.0735879494011 0.164735781739247 no 588 0.141503700487808 713 1826700 SGTC_999 SEC7.066 22.7 µM 1.07268827237125 0.164940081735947 no 589 0.141705502002256 781 740511 YDR170C SEC7 SGTC_3296 9122258 64.045 µM 1.07138454107036 0.165236425996444 no 590 0.141998280432553 721 4730474 SGTC_3123 9126162 49.47 µM 1.07074556068038 0.165381794998381 no 591 0.142141925444763 711 25239884 SGTC_2838 9002687 71.43 µM 1.07060135469583 0.165414613517944 no 592 0.142174357048331 678 6457060 SGTC_254 nsc-64875 3.808 µM 1.06795348197129 0.166017967489521 no 593 0.142770747910511 744 56993 SGTC_2195 6536160 144.242 µM 1.06650356812279 0.166348951944954 no 594 0.143098033298186 653 3834386 SGTC_1736 st036774 51 µM 1.0664786073697 0.166354653681758 no 595 0.143103672060319 766 1272247 SGTC_1490 4089-0339 670 nM 1.0615762656121 0.167476932250576 no 596 0.144214046628258 721 742542 SGTC_2581 avocatin a 64 µM 1.06130505658739 0.167539161398772 no 597 0.144275644243806 752 6710728 A skin care supplement. SGTC_3280 9140961 49.47 µM 1.05847734855548 0.168188868592541 no 598 0.144918936156691 708 4901226 SGTC_1440 4100-1550 40 µM 1.05757969286559 0.168395456599046 no 599 0.145123552324394 737 742806 SGTC_325 2810-4341 181 µM 1.05575775401546 0.168815262204705 no 600 0.145539451806986 755 774970 SGTC_989 1501-0895 10.3 µM 1.05251150992249 0.169564916841966 no 601 0.146282466297909 761 2830112 SGTC_2703 st077852 53.4 µM 1.05234009962371 0.169604559870511 no 602 0.146321770110248 707 6281836 SGTC_1983 st071813 46.9 µM 1.04998180310559 0.170150579977044 no 603 0.1468632395569 759 11838595 SGTC_2961 9083290 32.55 µM 1.04881110709291 0.170422050983869 no 604 0.147132532217586 707 17741490 SGTC_1053 3366-3204 134 µM 1.04845621104888 0.17050440207733 no 605 0.147214233533198 735 3632071 YPR165W RHO1 SGTC_204 PMA1.184 62.41 µM 1.04724533400522 0.170785569202166 no 606 0.147493220776415 808 2252213 YGL008C PMA1 SGTC_2417 cerulenin 830 nM 1.04711257107697 0.170816414956275 no 607 0.147523831017559 733 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_1273 0849-0096 14.1 µM 1.04467508381242 0.171383367196028 no 608 0.148086582165101 744 5286025 SGTC_476 mead acid 10 µM 1.04219274351978 0.17196198686176 no 609 0.148661163340087 695 5312531 An omega 9 fatty acid. SGTC_2972 9093619 59.92 µM 1.03908713307992 0.172687641406267 no 610 0.149382107245786 739 25236256 SGTC_2319 6033012 152.6 µM 1.03895885864075 0.172717655833939 no 611 0.149411935291988 707 847246 SGTC_886 0866-0150 153 µM 1.0358764473201 0.173439896945865 no 612 0.150129893434202 815 271463 SGTC_901 1112-0062 60.1 µM 1.03465852854429 0.173725797091117 no 613 0.15041420504136 742 1908457 SGTC_2659 sanguinarine 24.21 µM 1.03306295440651 0.174100803266465 no 614 0.150787219196796 747 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_3049 9092223 49.47 µM 1.03284167350144 0.17415285129282 no 615 0.150838998948731 726 8623917 SGTC_3059 1327-0034 3 µM 1.03269664961792 0.174186968081585 no 616 0.150872940970911 754 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_583 1488-1091 88.9 µM 1.02904538468854 0.175047325580293 no 617 0.151729174297811 905 4303273 SGTC_406 estrone 100 µM 1.02406079318492 0.176226202834848 no 618 0.15290328070676 786 5870 A steroid. SGTC_599 1935-0052 86.5 µM 1.02351169255964 0.176356374028726 no 619 0.153032987185899 795 9557311 SGTC_1903 st060211 78.3 µM 1.02296726344388 0.176485497828058 no 620 0.153161662167729 813 688960 SGTC_766 1391-0721 126 µM 1.02272928511064 0.176541958603242 no 621 0.153217930494853 785 1020919 YIL115C NUP159 SGTC_1155 4088-0394 48.2 µM 1.02187235200105 0.176745362098509 no 622 0.153420659847257 761 2326248 SGTC_1601 4'-hydroxyflavanone 55.5 µM 1.02145497836724 0.176844484437803 no 623 0.153519464527024 831 165506 SGTC_1919 st067113 52.3 µM 1.02067680916254 0.177029386158257 no 624 0.153703792692202 770 1268243 SGTC_3192 9110362 49.47 µM 1.01974962349547 0.177249855270329 no 625 0.153923610223384 805 16649480 SGTC_2635 hydroquinidine 100 µM 1.01939535599158 0.177334139871534 no 626 0.154007655001073 788 442912 An experimental heart treatment. SGTC_733 4069-0007 56.1 µM 1.01921254194279 0.177377643481943 no 627 0.154051036831776 831 5717425 YNL287W SEC21 SGTC_692 k241-0027 77.8 µM 1.01494860404475 0.178394228465953 no 628 0.155065163857686 763 3600480 SGTC_914 3820-6779 408 µM 1.01438469535961 0.178528946818014 no 629 0.15519961213836 754 2893481 SGTC_2026 5148700 152 µM 1.00674576993639 0.180360203080168 no 630 0.157028480539571 788 79838 SGTC_214 4373-3496 70 µM 1.00600855518473 0.180537554788307 no 631 0.157205727356366 963 3779166 SGTC_144 4161-2749 112.381 µM 1.00510747072555 0.180754477120121 no 632 0.157422551581108 712 797501 YMR168C CEP3 SGTC_105 0111-0055 734.78 µM 1.00500160184728 0.180779974159404 no 633 0.157448039268476 695 5179370 SGTC_920 mycophenolic acid 780.421 nM 1.00438675120384 0.180928096908577 no 634 0.157596116749157 766 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_300 r073-0011 5.04 µM 1.00363674211776 0.181108883419624 no 635 0.157776868942294 881 2735780 SGTC_2358 9037157 4 µM 0.998815903876597 0.182273625861234 no 636 0.158941940159893 796 2388925 SGTC_263 alizarin 107.927 µM 0.998544043915095 0.182339447937441 no 637 0.159007809145852 865 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_1297 1068-0111 14.1 µM 0.998176011391253 0.18242857874074 no 638 0.159097008286776 770 767057 SGTC_2628 lathosterol 100 µM 0.997890572056039 0.182497725709327 no 639 0.159166212085882 803 6710616 SGTC_2674 ligustilide 100 µM 0.995636716673991 0.183044291398298 no 640 0.159713344100349 767 5319022 A signalling regulator. SGTC_2064 5220758 200 µM 0.993958790150302 0.183451855315371 no 641 0.160121465336838 844 788518 SGTC_2359 9039622 200 µM 0.992956028086008 0.183695693406341 no 642 0.160365691865357 846 6463596 SGTC_650 1328-0195 38 µM 0.99136903247602 0.184082009946851 no 643 0.160752707919677 814 2780821 SGTC_1168 k815-0004 80.5 µM 0.990417942021617 0.184313772616782 no 644 0.16098493964463 808 642433 SGTC_3350 9150499 3.57 µM 0.990412656912085 0.184315061004592 no 645 0.160986230743352 857 4910996 YPR165W RHO1 SGTC_2779 methotrexate 400 µM 0.98787039692017 0.184935454906031 no 646 0.161608062585442 855 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2274 7947094 46.08 µM 0.987863096817456 0.184937238234229 no 647 0.161609850427844 848 2971028 SGTC_341 1486-1430 230 µM 0.987067597135985 0.185131633362183 no 648 0.161804750700947 783 2054753 YPL210C SRP72 SGTC_2557 derrustone 83.84 µM 0.986679342485548 0.18522655667275 no 649 0.161899930077342 828 629853 An antioxidant. SGTC_3285 9112818 20.8695 µM 0.98621686043451 0.185339667073509 no 650 0.162013353655025 865 17017947 YPR165W RHO1 SGTC_180 1486-1293 102.781 µM 0.984415917958171 0.18578053662654 no 651 0.162455527303274 835 4140536 SGTC_1533 dihydroergotamine mesylate 29.4 µM 0.984215354108829 0.185829674750291 no 652 0.16250481899183 857 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.983679014076218 0.18596111760174 no 653 0.162636680710151 814 5357218 A potent inhibitor of glutathione S-transferases. SGTC_2326 6164455 177.58 µM 0.982614952700644 0.186222061672012 no 654 0.162898491174065 753 2888790 SGTC_1990 st072050 59.8 µM 0.98234406266954 0.186288529348028 no 655 0.162965186936849 823 17233948 SGTC_3256 9138902 49.47 µM 0.982090160804214 0.186350842020095 no 656 0.163027716163558 846 17228773 SGTC_3217 9129673 49.47 µM 0.980505480540852 0.186740046464008 no 657 0.163418332833716 775 17248312 SGTC_2488 5268135 45.7 µM 0.977924664010409 0.187374982463323 no 658 0.164055792807605 882 1270356 YLR208W SEC13 SGTC_530 4358-1714 28 µM 0.977491847476975 0.18748159509801 no 659 0.164162855939446 864 1564641 SGTC_2250 alverine citrate 130 µM 0.977073932764846 0.187584572640455 no 660 0.164266275892863 870 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_291 SEC14.278 35.5 µM 0.97156828891068 0.18894446862516 no 661 0.165632682405963 848 1068044 SGTC_2087 5276107 200 µM 0.968998546992333 0.189581269502993 no 662 0.166272957070148 829 144405 SGTC_1336 1486-0901 104 µM 0.968798155856646 0.189630983331658 no 663 0.166322953449715 836 5006114 SGTC_2695 st077686 51.995 µM 0.968146581686995 0.189792683861775 no 664 0.166485584369185 786 2876092 SGTC_3187 9109394 49.47 µM 0.967696832067389 0.189904347236385 no 665 0.166597900363668 819 17098090 SGTC_1981 st071826 47 µM 0.967037819795255 0.190068039061757 no 666 0.166762563839481 783 11838600 SGTC_2966 9084041 48.03 µM 0.966945493523329 0.190090978875171 no 667 0.166785641239212 764 17741380 SGTC_2815 7968870 71.43 µM 0.96586349512462 0.190359944008334 no 668 0.167056245542864 838 2977326 YHR190W ERG9 SGTC_2473 5854593 8.94 µM 0.965550547396007 0.190437780683018 no 669 0.167134565512961 808 2872951 SGTC_1010 4112-3296 15.2 µM 0.96266074959529 0.19115745727189 no 670 0.167858900087408 881 704384 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 0.962626594370231 0.191165973263723 no 671 0.167867473240823 857 688669 SGTC_247 mechlorethamine 29.705 µM 0.962253776011923 0.191258943950241 no 672 0.167961071074367 793 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1019 4262-0212 3.4 µM 0.961118004045007 0.191542345158844 no 673 0.168246419058666 921 4677213 SGTC_196 k015-0023 18.111 µM 0.960782727233283 0.191626053583577 no 674 0.168330712592522 866 5211998 SGTC_3054 9094397 49.47 µM 0.960654534082656 0.191658065435731 no 675 0.168362949417725 858 2598354 SGTC_575 k072-0246 11.9 µM 0.960113797906158 0.191793131831663 no 676 0.168498972431946 863 6796779 SGTC_1487 3970-0795 2.82 µM 0.959973105606172 0.191828283848323 no 677 0.16853437537622 864 3765103 SGTC_2202 7226349 200 µM 0.957869039361112 0.192354455955664 no 678 0.169064400123788 814 844334 SGTC_2228 7354201 200 µM 0.957303974992108 0.192495914021716 no 679 0.169206924801042 866 753451 SGTC_2950 9072895 21.46 µM 0.953114340268165 0.193546728730668 no 680 0.17026607055149 847 17332245 SGTC_1897 st060201 15 µM 0.952713908788309 0.193647344988907 no 681 0.170367522113925 783 611878 SGTC_819 1013-0258 27.7 µM 0.952019955267106 0.193821789931073 no 682 0.1705434308058 838 5753198 SGTC_1850 st056238 17 µM 0.951010165940129 0.194075800221529 no 683 0.170799607651224 900 5393177 SGTC_2380 9035439 200 µM 0.950932570611299 0.19409532754348 no 684 0.170819303254464 902 6462575 SGTC_2258 7960471 200 µM 0.950307580342612 0.194252653670879 no 685 0.170977994153797 747 2974708 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.949786538543418 0.194383872635071 no 686 0.171110363623484 933 1377 SGTC_2508 celastrol 40.54 µM 0.947620025324704 0.194930064936396 no 687 0.171661463926785 814 122724 Celastrol is a natural product and antioxidant. SGTC_3223 9129970 49.47 µM 0.947358940640415 0.194995949060191 no 688 0.171727953033265 882 17248386 SGTC_2964 9083345 53.42 µM 0.945642314041617 0.195429472920281 no 689 0.172165527149261 804 17741579 SGTC_3169 9102970 49.47 µM 0.943368054985529 0.196004724295436 no 690 0.172746338502239 883 17027839 SGTC_2411 st077133 39.94 µM 0.941967145724593 0.196359581155041 no 691 0.173104730420802 919 1403142 YNL221C POP1 SGTC_2247 cerulenin 830 nM 0.940830414773731 0.196647806411077 no 692 0.173395885913596 850 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_584 0986-0246 15.4 µM 0.939957869677564 0.196869219451135 no 693 0.173619585770911 945 53315 YDR232W HEM1 SGTC_1866 st057638 64 µM 0.9392418919646 0.197051015366243 no 694 0.173803282564158 845 688802 SGTC_2031 5180455 200 µM 0.938661066513739 0.197198569008112 no 695 0.173952394430915 828 29949 SGTC_2304 7443016 91.4 µM 0.934055635662801 0.198370903359285 no 696 0.175137597473594 796 939854 SGTC_252 miconazole 1.30953 nM 0.933995666820171 0.198386196399469 no 697 0.175153064101215 852 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_1842 st055362 61.2 µM 0.93213184456599 0.198861856280612 no 698 0.175634196310382 922 676032 SGTC_1164 k060-0068 93.7 µM 0.931874000779669 0.198927713823037 no 699 0.175700822695009 932 5963676 SGTC_2887 9044784 58.44 µM 0.930995430873006 0.199152213704334 no 700 0.175927963844259 975 6465546 SGTC_961 1252-1571 372 µM 0.928318891655483 0.199837086571632 no 701 0.176621088672152 888 6813498 SGTC_912 3474-0017 2.18 µM 0.927330319186494 0.200090400301647 no 702 0.176877528529777 901 3360550 SGTC_2071 5230951 39.92 µM 0.927123001383842 0.200143548291781 no 703 0.176931337474988 939 1799272 SGTC_146 3448-8650 53.125 µM 0.926594076251139 0.20027918196749 no 704 0.177068665854076 969 2891488 YIL048W NEO1 SGTC_1547 harmine 94.2 µM 0.925483433609309 0.200564166692004 no 705 0.177357248541105 944 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_1339 1486-1321 22.7 µM 0.923644561503076 0.201036546036787 no 706 0.17783570242529 883 3469382 SGTC_3046 9092212 49.47 µM 0.923289698685951 0.201127781863296 no 707 0.177928127376783 865 25236637 SGTC_2495 cafestol 54.53 µM 0.922909051513037 0.201225674489094 no 708 0.17802730159946 821 16667697 An anti-infammatory. SGTC_2044 5102272 200 µM 0.922689699825707 0.201282099052344 no 709 0.178084467549529 803 592666 SGTC_1033 k072-0102 21.3 µM 0.921221303852444 0.201660063643478 no 710 0.178467448936108 896 5965931 SGTC_3161 9100388 49.47 µM 0.920297756947289 0.20189800190763 no 711 0.17870859045922 937 25236368 SGTC_941 3237-0776 460 µM 0.918149901490714 0.20245201481359 no 712 0.179270196368097 872 760008 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.917213468165503 0.202693840538744 no 713 0.179515395324347 836 6708760 SGTC_2908 7930301 100 µM 0.914773909969043 0.2033246452152 no 714 0.180155167055427 941 2223178 SGTC_1510 1123-0200 71.5 µM 0.914451919316905 0.203407990833238 no 715 0.18023971557695 946 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_2283 7944793 200 µM 0.913215676096343 0.203728175318869 no 716 0.180564560448616 902 2970533 SGTC_3211 9128781 49.47 µM 0.912481931895313 0.203918355591882 no 717 0.180757538307496 822 17194361 SGTC_581 0958-0271 211 µM 0.910753272058702 0.204366827586119 no 718 0.181212694138487 961 4591145 SGTC_1485 3909-9022 254 µM 0.910274507992375 0.204491138698207 no 719 0.181338879457803 958 714516 SGTC_2618 avocadyne 43.43 µM 0.908751347982445 0.204886926485313 no 720 0.181740696544442 891 3015189 SGTC_843 0310-0051 143 µM 0.908382646097331 0.204982800806188 no 721 0.181838045586331 884 2065037 SGTC_179 1273-0063 6.77 µM 0.907292792741403 0.20526635353746 no 722 0.182125992238087 850 3108139 SGTC_2351 9026858 72.31 µM 0.907169132909657 0.20529854146283 no 723 0.182158682000742 835 1409300 SGTC_1272 0839-0021 27 µM 0.907008994537517 0.205340228992529 no 724 0.182201020399622 898 5027250 SGTC_207 4185-0010 4.486 µM 0.905727326494155 0.205674056409212 no 725 0.182540097494755 995 3761753 SGTC_2363 9053361 176 µM 0.904963874417189 0.205873060607255 no 726 0.182742262958471 912 6469797 YMR079W SEC14 SGTC_1160 4092-0570 10.5 µM 0.903785701487236 0.20618039151912 no 727 0.183054522507776 899 4994975 SGTC_574 1315-0397 40 µM 0.903356043046614 0.206292537211342 no 728 0.183168480725918 1018 6794277 SGTC_2553 4-methylesculetin 85.09 µM 0.903139062619472 0.206349185282736 no 729 0.183226047211312 933 5319502 SGTC_3033 9090887 49.47 µM 0.902519817053733 0.20651090523895 no 730 0.183390399606346 927 19325384 SGTC_1719 st032227 49.2 µM 0.902489482743948 0.206518829167315 no 731 0.183398452919295 902 3125804 SGTC_531 3788-1495 174 µM 0.9022118088245 0.206591371517999 no 732 0.183472181505451 853 2896655 SGTC_1255 0566-0045 221 µM 0.899012711663348 0.207428224112002 no 733 0.184322944915973 901 2788469 SGTC_2130 NSC 7 2.4545 µM 0.89353490938154 0.20886580794647 no 734 0.185785393036304 956 21448 SGTC_1064 honokiol 6.76 µM 0.892043418222977 0.209258246356842 no 735 0.186184830364997 914 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_1260 0700-1617 7.75 µM 0.891932257941292 0.209287512014646 no 736 0.186214621577095 915 2853078 SGTC_2729 fluphenazine 10.66 µM 0.89162630413095 0.209368074263237 no 737 0.186296633157924 944 3372 An atypical antipsychotic. SGTC_1776 st049249 45.9 µM 0.89154438894431 0.209389646862927 no 738 0.186318594498354 947 1822314 SGTC_1676 st018489 23.4 µM 0.890404102366257 0.209690080414434 no 739 0.186624470194131 900 3696235 SGTC_1152 3909-8331 15.9 µM 0.890385176294829 0.209695069041307 no 740 0.186629549631859 887 16001939 SGTC_1724 st037281 8.293 µM 0.889757596389054 0.209860529156808 no 741 0.186798029948835 900 574124 YDL195W SEC31 SGTC_1966 st070145 16.1 µM 0.888953013330811 0.210072767999037 no 742 0.187014166250563 908 3748532 SGTC_1722 st034304 3.6505 µM 0.887437446017287 0.210472897818741 no 743 0.187421715252581 908 4036148 YLR033W RSC58 SGTC_335 4077-0256 27.6 µM 0.887368610029496 0.210491082044147 no 744 0.187440238861685 1008 3121989 SGTC_444 curcumin 90.4 µM 0.886858936007592 0.210625750003052 no 745 0.187577426195236 893 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_3091 9116372 49.47 µM 0.886423395805557 0.210740870096962 no 746 0.18769470831249 884 17169793 SGTC_1880 MG-132 525 µM 0.886010619800452 0.210850007314637 no 747 0.187805902294098 882 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_1845 st056753 3.01 µM 0.885153902413411 0.211076627575019 no 748 0.188036815425148 927 5375839 SGTC_1849 st056239 19.2 µM 0.879927093069087 0.212462320803936 no 749 0.18944940327108 896 5393181 SGTC_1759 st043059 70 µM 0.87898814496981 0.212711809723981 no 750 0.189703851861165 932 669426 SGTC_277 nystatin 15.5 µM 0.878355883104546 0.212879905041291 no 751 0.189875308921976 996 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_1259 0671-0132 43 µM 0.877481543733094 0.213112487609007 no 752 0.190112569595016 890 X1259 SGTC_2203 7227154 166.4 µM 0.877458077128703 0.213118731990239 no 753 0.190118940000695 970 896304 SGTC_830 4076-0286 57.8 µM 0.876931350728316 0.213258920120685 no 754 0.190261963283016 1033 6866659 SGTC_3009 9080819 71.4286 µM 0.874423440043778 0.213927137177973 no 755 0.19094384843457 933 17027216 SGTC_1738 st035555 74 µM 0.873864257656778 0.21407629383889 no 756 0.191096090748656 942 5331140 SGTC_1784 st039334 36.3 µM 0.872159599106653 0.214531368848308 no 757 0.191560658139488 936 3496984 SGTC_1464 k208-0027 110 µM 0.871994564493513 0.214575456266268 no 758 0.19160567141586 959 X1464 SGTC_1901 st060216 58.6 µM 0.871928469327197 0.214593114434484 no 759 0.191623700723582 992 688792 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.871914351462458 0.214596886311918 no 760 0.191627551901261 944 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1954 st077032 68.9 µM 0.871858150480409 0.214611901940236 no 761 0.191642883299228 853 698907 SGTC_2300 7976697 71.57 µM 0.871638485984543 0.214670597171539 no 762 0.191702814081333 834 2236109 SGTC_1965 Pectolinarigenin 58.4 µM 0.87031882510134 0.215023412157739 no 763 0.192063097002879 966 5320438 An anti-inflammatory. SGTC_330 1488-0319 80.1 µM 0.870081958576254 0.21508677470097 no 764 0.192127808177595 924 6846614 SGTC_2842 9000675 19.48 µM 0.869974229170307 0.215115596243122 no 765 0.192157243918329 884 2989072 SGTC_1770 st043884 66.3 µM 0.869595185154747 0.215217022152078 no 766 0.192260834983368 983 670149 SGTC_3070 9117005 49.47 µM 0.867682737467619 0.215729184647518 no 767 0.192784019297482 923 8779016 SGTC_321 4534-3890 65.3 µM 0.866780416497069 0.215971075563051 no 768 0.193031167076731 976 699746 SGTC_1188 1403-0014 4.57 µM 0.86502778529867 0.216441363302177 no 769 0.193511769304397 990 9614867 SGTC_2128 5255449 168.493 µM 0.864155701908985 0.216675592169093 no 770 0.193751181579665 1004 736008 SGTC_1613 st002381 52.1 µM 0.863616043487448 0.216820609944176 no 771 0.193899423931945 1007 551167 SGTC_2867 9039098 71.43 µM 0.863370142619962 0.216886707379801 no 772 0.19396699499177 902 6463460 SGTC_2821 7996764 71.43 µM 0.861324731607507 0.217436959125009 no 773 0.194529609061036 1001 2987135 SGTC_1474 0330-0125 5.35 µM 0.861303526386391 0.217442667922415 no 774 0.194535447000382 987 X1474 SGTC_496 calpeptin 138 µM 0.861256608847998 0.217455299209824 no 775 0.194548364091765 882 73364 A calpain inhibitor. SGTC_345 1362-0200 395 µM 0.858835847146218 0.218107598836995 no 776 0.195215543620695 925 1419823 SGTC_2582 agaric acid 100 µM 0.857867227455727 0.218368919161084 no 777 0.195482891260779 1022 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_370 0180-0345 38.7 µM 0.857197877203265 0.218549606016726 no 778 0.195667767734438 892 3989527 SGTC_2104 5389443 200 µM 0.856087627513852 0.218849500609111 no 779 0.195974655858663 993 2244536 SGTC_1963 st076565 50.3 µM 0.855258155372567 0.219073707540268 no 780 0.196204123709149 957 4914280 SGTC_2652 actinonin 100 µM 0.855036416513894 0.219133666083845 no 781 0.196265493849485 939 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_3037 9091026 49.47 µM 0.85438925486134 0.219308713577398 no 782 0.196444673790689 1033 25236398 YIL048W NEO1 SGTC_3281 9140613 49.47 µM 0.853116009198625 0.219653341862742 no 783 0.196797487163929 904 16013766 SGTC_3016 9080866 49.47 µM 0.851687531183191 0.220040356658405 no 784 0.197193771465223 1012 17066299 SGTC_956 1185-0240 191 µM 0.851342637179881 0.220133856719835 no 785 0.197289523284597 944 1416193 SGTC_507 nimesulide 162 µM 0.849765649151281 0.220561665154925 no 786 0.197727695605006 979 4495 A COX2 inhibitor. SGTC_2523 spermine 47.74 µM 0.849574820150571 0.220613465914125 no 787 0.19778075805148 969 1103 A DNA binding polyamine. SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.848992527232186 0.220771573093013 no 788 0.197942725228056 922 688803 SGTC_3032 9089427 49.47 µM 0.848883296860192 0.220801239113655 no 789 0.197973117028016 956 17173707 SGTC_827 3253-0474 693 µM 0.843485612228444 0.222270044231626 no 790 0.199478454559145 1019 5402065 SGTC_2178 5812956 200 µM 0.842984918515177 0.222406573788481 no 791 0.199618439264722 1007 5403383 SGTC_693 4161-2696 114 µM 0.842950617129293 0.222415928867861 no 792 0.199628031461153 946 805759 SGTC_1442 4112-3290 3 µM 0.842117749112243 0.22264314735208 no 793 0.199861023601421 1022 704353 SGTC_3310 9130229 44.1445 µM 0.841345299011027 0.222854001172154 no 794 0.200077260139678 959 7761258 SGTC_2874 9043904 71.43 µM 0.841143072374849 0.222909221269525 no 795 0.200133893861861 885 4463428 SGTC_71 0417-1750 47.813 µM 0.83923013516465 0.223431954221432 no 796 0.200670089882087 994 6811472 SGTC_955 1216-0110 33 µM 0.838276962668742 0.223692680107204 no 797 0.200937585607913 943 3619719 SGTC_2952 9073731 13.78 µM 0.837525981131052 0.223898221499084 no 798 0.201148489615437 1043 16457353 SGTC_1554 st069299 38.7 µM 0.836799426247175 0.224097179496239 no 799 0.201352659984903 1012 24207999 SGTC_2497 7-hydroxyflavone 100 µM 0.83598174714593 0.224321210777884 no 800 0.201582585823153 926 5281894 SGTC_1196 1588-0294 184 µM 0.832574406430872 0.225256136412674 no 801 0.202542399119063 936 6144269 SGTC_1765 st044815 90.4 µM 0.832395276017853 0.225305348224037 no 802 0.202592933810818 979 645695 SGTC_1154 4088-0362 150 µM 0.829298806393637 0.226156991130953 no 803 0.203467673068515 1067 6618304 SGTC_1646 st011709 75.6 µM 0.828639130486318 0.226338661013534 no 804 0.20365431936268 967 5757843 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.828553120627846 0.22636235356733 no 805 0.203678662199248 981 5355888 SGTC_3074 9116018 49.47 µM 0.828546263616111 0.226364242482246 no 806 0.2036806029714 977 17027303 SGTC_3122 9126309 49.47 µM 0.827352358052275 0.226693265757634 no 807 0.204018687725566 1072 17591206 SGTC_510 ag-490 170 µM 0.827029759420779 0.226782215613084 no 808 0.204110097084191 1105 5328779 SGTC_145 3737-0113 38.366 µM 0.826510512367154 0.226925428524266 no 809 0.20425727862891 1100 6849351 SGTC_1588 farnesol 29.9 µM 0.825761838462802 0.2271320091472 no 810 0.204469602856806 981 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_772 k072-0172 35.3 µM 0.823518981723165 0.22775151179117 no 811 0.205106463689855 947 5861980 SGTC_1151 3909-8316 15.3 µM 0.822473237827284 0.22804068296338 no 812 0.205403805968019 996 800431 SGTC_347 4534-1311 26.2 µM 0.821879018034094 0.228205089759241 no 813 0.205572877846758 1017 2862016 SGTC_3072 9116419 49.47 µM 0.818710711853203 0.229082810356331 no 814 0.206475741811122 984 17170162 SGTC_2943 9068529 45.32 µM 0.816327742403444 0.229744213799968 no 815 0.207156355722615 1108 3270634 SGTC_1633 st005664 67.9 µM 0.815749471416428 0.229904876495036 no 816 0.207321718969863 1056 2063822 SGTC_1283 0922-0125 16.4 µM 0.814292751440573 0.230309879844195 no 817 0.207738630618893 1054 3360884 SGTC_913 3487-1245 167 µM 0.813102388957699 0.23064112537207 no 818 0.208079678447111 987 4016153 SGTC_1467 k284-1082 293 µM 0.810753905897613 0.231295424355204 no 819 0.208753504922299 1030 3334705 SGTC_3113 9123498 49.47 µM 0.809776070703115 0.231568159062377 no 820 0.209034444022485 1103 8897275 SGTC_1624 st003710 6.25 µM 0.809109203902318 0.23175426221299 no 821 0.209226167305065 1078 24207033 SGTC_1692 fluoroquinolonic acid 71 µM 0.80814203210675 0.232024319767408 no 822 0.209504411713984 1002 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1612 st002233 45.4 µM 0.807422991196524 0.232225206724354 no 823 0.209711412671955 1058 1035021 SGTC_2513 baicalein 25.65 µM 0.806904324706326 0.232370172777867 no 824 0.209860803511127 1039 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_1887 st057648 70.8 µM 0.806079432240229 0.232600831923773 no 825 0.210098525033747 1028 688672 SGTC_2450 5739737 12.93 µM 0.804579787071777 0.233020493504419 no 826 0.210531105063226 992 2262825 SGTC_1647 st011722 22.4 µM 0.803738908436376 0.233255989333796 no 827 0.210773889186713 1003 2854783 SGTC_2681 menadione 3.18 µM 0.803700266410114 0.233266814563751 no 828 0.210785050117158 1038 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_3189 9110682 49.47 µM 0.802252622616054 0.233672560289898 no 829 0.2112034210318 1021 17122418 SGTC_2165 5727197 32.143 µM 0.800666021181906 0.234117702125287 no 830 0.211662509279209 1035 1361712 SGTC_553 k007-0256 45.7 µM 0.800640995781812 0.234124727089151 no 831 0.211669755135499 1059 6287000 SGTC_1766 st045414 44.774 µM 0.799557550085243 0.234428976653882 no 832 0.211983595268946 1111 253960 SGTC_2290 7904846 200 µM 0.798646099116131 0.234685096578858 no 833 0.212247824596879 1042 2962154 SGTC_2607 solasodine 47.35 µM 0.798477861916759 0.234732388548157 no 834 0.212296617541874 1036 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_903 1134-0042 114 µM 0.798125520134566 0.23483144992501 no 835 0.212398826604233 1029 701009 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 0.79731073034503 0.23506061767423 no 836 0.212635294985861 1030 6708514 SGTC_1728 st035614 33.7865 µM 0.796729761188208 0.235224096459636 no 837 0.212803997770296 1044 15945546 SGTC_2376 9072922 81.32 µM 0.795926814905008 0.23545014064617 no 838 0.213037287207489 1053 17087968 SGTC_231 b-estradiol 524 µM 0.795341657903551 0.235614948616303 no 839 0.213207393711025 998 450 A steroid. SGTC_2428 5615643 7.78 µM 0.794385567891209 0.235884365791582 no 840 0.213485501685314 1017 2253075 SGTC_1029 k015-0030 64.7 µM 0.793127810373262 0.236239048523109 no 841 0.213851680679238 1017 2208316 SGTC_1181 1222-0449 220 µM 0.792593969500267 0.236389678311819 no 842 0.214007211679585 1051 658318 SGTC_76 0433-0009 400.328 µM 0.792588148086804 0.23639132118682 no 843 0.214008908072647 933 2841569 SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.787906004943362 0.23771471353578 no 844 0.215375844217222 1160 688801 SGTC_983 1491-0821 12.2 µM 0.787495358535866 0.237830974939151 no 845 0.215495972212774 1053 46495113 SGTC_1922 5578187 25 µM 0.787415327301163 0.237853636855311 no 846 0.215519388586286 1037 1350412 SGTC_503 tyrphostin 8 294 µM 0.787333575026541 0.237876787329557 no 847 0.215543310043249 1049 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_3078 9116413 49.47 µM 0.786854213606657 0.238012556965382 no 848 0.215683606524531 1044 17177322 SGTC_153 4077-0274 519.67 µM 0.785676390416941 0.238346332408626 no 849 0.216028549164235 1028 3121976 SGTC_2315 7733312 200 µM 0.78560011094513 0.238367957573434 no 850 0.216050899729061 1019 726316 SGTC_1180 1193-0155 285 µM 0.783328187054455 0.239012538393996 no 851 0.216717207487792 1048 2921347 SGTC_2731 amoxapine 43.43 µM 0.783143163427872 0.239065074460288 no 852 0.216771523329738 1066 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2816 7982706 58.44 µM 0.782405963724115 0.239274459434214 no 853 0.216988015043541 1033 2981853 SGTC_1506 4226-2149 212 µM 0.781655932484297 0.239487591698277 no 854 0.217208403150476 1097 991114 SGTC_2206 7254556 146.969 µM 0.780924650226798 0.23969549593261 no 855 0.217423406521852 1071 4398905 SGTC_1199 1638-0010 4.46 µM 0.780704614879469 0.239758071460213 no 856 0.217488122875059 1030 3111136 SGTC_2055 5235184 200 µM 0.780610494658124 0.239784840892592 no 857 0.217515808720103 1038 2836034 SGTC_921 1561-0023 372 µM 0.779592016628229 0.240074618075834 no 858 0.217815528247818 1129 24050882 SGTC_868 0527-0199 213 µM 0.77941586171739 0.240124756997608 no 859 0.21786739158116 1034 2849450 SGTC_1562 morin hydrate 59.1 µM 0.778634390438774 0.240347255756467 no 860 0.218097557349409 1052 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_3221 9128209 49.47 µM 0.778632678033927 0.240347743431848 no 861 0.218098061855736 1031 16460723 SGTC_2598 perillyl alcohol 100 µM 0.776642480768558 0.240914895479561 no 862 0.218684865549051 1074 10819 An apoptosis inducer. SGTC_3290 9121031 71.43 µM 0.774465697368932 0.241536052119619 no 863 0.219327722917083 1036 17014854 SGTC_224 benfluorex 43.875 µM 0.773156328769 0.241910105866428 no 864 0.219714934012837 1073 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_820 1582-0060 59.9 µM 0.772341574638918 0.242143019191884 no 865 0.219956073938958 1047 3848840 SGTC_540 1187-0821 17.3 µM 0.771824131584374 0.242291003463058 no 866 0.220109298563012 1033 847520 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.770513120780578 0.242666160605293 no 867 0.220497787478321 1105 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_1783 st039459 87.517 µM 0.770278377546789 0.242733367604562 no 868 0.220567389871765 1129 729761 SGTC_3208 9114115 49.47 µM 0.769065511336181 0.243080771716755 no 869 0.220927210480204 1012 650895 SGTC_2967 9089538 49.85 µM 0.768395873143599 0.243272692904075 no 870 0.221126015705092 1110 728216 SGTC_380 3970-0968 6 µM 0.768281785750511 0.243305399005649 no 871 0.221159896690307 1047 2891601 SGTC_2091 4-phenylthiadiazole 200 µM 0.767044268328213 0.243660318026437 no 872 0.221527597927144 1083 270010 SGTC_1248 0469-0687 58.6 µM 0.764757860317946 0.244316792747853 no 873 0.222207872477491 1078 4017482 SGTC_1363 1636-0063 10.4 µM 0.763517753116296 0.2446732513589 no 874 0.222577339413791 1136 6072185 SGTC_2799 7812892 81.82 µM 0.762652263709636 0.244922194996247 no 875 0.222835403312509 1090 20205235 SGTC_1165 k072-0275 30.3 µM 0.761368507016822 0.245291697136198 no 876 0.223218496205039 1106 6153523 YGL055W OLE1 SGTC_1035 k081-0041 55.2 µM 0.761132058031294 0.245359786627484 no 877 0.223289097108982 1126 731709 SGTC_381 3461-2219 42.7 µM 0.760234232802269 0.245618423106276 no 878 0.223557292947846 1103 2883159 SGTC_593 1203-0218 61.7 µM 0.760054578617907 0.245670193655905 no 879 0.223610980733075 1143 3666956 SGTC_681 1642-0006 26.6 µM 0.758968872360182 0.245983183904514 no 880 0.223935588764864 1117 4446530 SGTC_742 0kpi-0133 140 µM 0.758697629013268 0.246061412038096 no 881 0.224016727777688 1112 2728852 SGTC_423 5-fluorouracil 457 µM 0.758451703483572 0.246132349901891 no 882 0.224090307720236 1066 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2236 dapsone 200 µM 0.758025742870763 0.246255245305043 no 883 0.224217785919871 1137 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_48 0382-0018 55 µM 0.757877899734213 0.246297907741105 no 884 0.224262040895477 1179 762596 SGTC_3036 9090181 49.47 µM 0.757508203560667 0.246404606660549 no 885 0.224372726478862 1093 25236586 SGTC_3222 9128301 49.47 µM 0.75729518590972 0.246466097454593 no 886 0.224436517205735 1147 4911358 SGTC_2323 6148992 148.28 µM 0.757274731605597 0.24647200233411 no 887 0.224442643037486 1027 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_771 0250-0039 27.3 µM 0.75670301312285 0.246637080353886 no 888 0.224613904616877 1060 3005115 SGTC_424 splitomicin 100 mM 0.755667475765116 0.246936232157366 no 889 0.224924294483905 1029 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_3115 9123671 49.47 µM 0.75435711090601 0.247315055804401 no 890 0.225317408839346 1209 3286988 SGTC_3259 9138485 49.47 µM 0.753171593169245 0.247658053924497 no 891 0.225673403580648 1218 17646153 SGTC_2893 9048488 25.97 µM 0.752854828443941 0.247749744391 no 892 0.225768577535797 1080 6467338 SGTC_74 000s-0487 160.283 µM 0.75279875684874 0.247765976718569 no 893 0.225785426964255 1116 677548 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.752062013671033 0.247979311360329 no 894 0.226006883219392 1223 688664 SGTC_690 glyoxal 20.3 µM 0.75016095763012 0.248530242097645 no 895 0.226578884935168 1040 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2885 9057732 51.95 µM 0.749870051556438 0.24861460489152 no 896 0.226666486624372 1140 6471414 SGTC_2317 5986382 200 µM 0.749612887234235 0.248689195274587 no 897 0.226743943442583 1149 877883 SGTC_571 k831-0106 44.2 µM 0.74908986021123 0.248840935763127 no 898 0.226901523062388 1081 4783639 SGTC_526 4469-0568 170 µM 0.747695520481707 0.249245702032127 no 899 0.227321916862674 1134 2901964 SGTC_2180 6301957 200 µM 0.747523930113112 0.249295537599104 no 900 0.227373681714045 1110 845462 SGTC_2342 7990637 118.86 µM 0.747201402431677 0.249389224732499 no 901 0.227470998836915 1146 2033102 YER133W GLC7 SGTC_3135 9127742 49.47 µM 0.747077527801102 0.249425212537007 no 902 0.227508382088545 1042 3643468 SGTC_1100 amiodarone 5.07 µM 0.746934578757924 0.249466745230935 no 903 0.22755152597257 1146 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_167 3672-0051 66.205 µM 0.746298257281547 0.249651667896748 no 904 0.227743631976435 1091 3237971 SGTC_8 0354-0001 70 µM 0.745375583334859 0.24991993730463 no 905 0.22802235011453 1168 4993152 SGTC_706 4262-0057 46.9 µM 0.744827264073398 0.250079434743191 no 906 0.228188075333039 1111 883298 SGTC_776 4476-4378 112 µM 0.744166110438376 0.25027182571404 no 907 0.228387993884524 1057 2892008 SGTC_931 2812-0076 566 µM 0.743910055935733 0.250346356816712 no 908 0.228465445657132 1164 3450959 SGTC_2489 cantharidin 73.42 µM 0.742776705066572 0.250676388337856 no 909 0.22880844058064 1138 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_482 fipronil 114 µM 0.742634553348153 0.250717799144214 no 910 0.228851481469491 1134 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_3171 9103192 49.47 µM 0.742437281291573 0.250775273286424 no 911 0.228911219296961 1182 13018434 SGTC_2878 9043973 25.97 µM 0.741781087075187 0.250966502092281 no 912 0.229109990661999 1106 6465167 SGTC_2199 6590217 200 µM 0.74107453548803 0.251172492343068 no 913 0.229324124252543 1082 703109 SGTC_72 0744-0168 198.391 µM 0.740068996736532 0.251465804361622 no 914 0.229629064828711 1066 677577 SGTC_1329 1447-1697 50.6 µM 0.73814165853866 0.252028507519767 no 915 0.230214185564428 1084 2840515 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.737869899988723 0.252107903201623 no 916 0.230296755793136 1098 4620898 SGTC_349 k015-0014 24 µM 0.736351939743226 0.252551625787352 no 917 0.230758272353802 1108 2196908 SGTC_1804 st050076 49.1 µM 0.736346847157362 0.252553115118909 no 918 0.230759821558936 1131 3895976 SGTC_2036 5160441 105 µM 0.734857780146207 0.252988792581667 no 919 0.231213056705562 1143 134534 YIL048W NEO1 SGTC_1387 3342-1166 1.8 µM 0.734785009624804 0.253010094216806 no 920 0.231235218972891 1088 3418228 SGTC_1119 parthenolide 318.541 nM 0.734383341053244 0.253127688989109 no 921 0.231357568485719 1192 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2605 digitonin 300 nM 0.733800289028487 0.253298437750602 no 922 0.231535232193721 1198 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_3247 9135149 49.47 µM 0.732195765538757 0.253768640323787 no 923 0.232024544262559 1092 8934436 YOR116C RPO31 SGTC_580 1123-0028 41 µM 0.732003484723663 0.253825018586671 no 924 0.232083220417054 1220 1677248 YPR107C YTH1 SGTC_1331 1472-0049 76.2 µM 0.730957487479755 0.254131828425764 no 925 0.232402560173924 1126 24051409 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.730955058564207 0.254132541096753 no 926 0.232403301998719 1089 689007 SGTC_3145 9085516 49.47 µM 0.730318853865885 0.254319246760583 no 927 0.232597653161909 1154 25236195 SGTC_1991 st073000 8.92 µM 0.72978657263008 0.254475509451534 no 928 0.232760326636388 1167 4301969 YIL048W NEO1 SGTC_2690 usnic acid 100 µM 0.72959802669148 0.254530873261555 no 929 0.232817964385715 1187 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_1087 pterostilbene 9.05 µM 0.72850826071697 0.254850991004254 no 930 0.233151256874889 1165 5281727 Similar to reservatol, lowers cholesterol. SGTC_550 4123-0385 25.7 µM 0.727992516581536 0.25500256379685 no 931 0.233309083627386 1147 5731123 SGTC_2332 7982454 138.89 µM 0.727925754980458 0.255022187907962 no 932 0.233329518181481 1122 2981748 SGTC_2942 9052777 62.25 µM 0.726724194596502 0.255375513302992 no 933 0.233697464458092 1211 6469503 SGTC_2183 6420625 130.508 µM 0.725221825047572 0.255817652942723 no 934 0.234157977813287 1186 2897619 SGTC_2929 9013348 24.6 µM 0.724733918947979 0.255961327104803 no 935 0.234307641093641 1127 2995952 SGTC_3298 9116858 71.43 µM 0.724378787086974 0.256065929582079 no 936 0.234416609683025 1159 2506942 SGTC_1194 1488-0194 225 µM 0.724295110382401 0.256090579420877 no 937 0.234442289107759 1133 1391452 SGTC_981 1488-1094 54.9 µM 0.724089333006416 0.256151203457385 no 938 0.234505446453509 1131 3449522 SGTC_1920 st075728 45.7 µM 0.723258237271787 0.256396128555933 no 939 0.234760622726197 1131 3400306 SGTC_1829 berberine 14.4 µM 0.722529887994863 0.256610874423768 no 940 0.234984378296596 1149 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_576 1073-0113 22.7 µM 0.721346902259746 0.2569598644252 no 941 0.235348053336496 1318 5439563 SGTC_1773 st048542 73.5835 µM 0.717452503775261 0.258110484358381 no 942 0.23654746652813 1128 3237138 SGTC_3035 9091303 49.47 µM 0.716730557806638 0.258324080145015 no 943 0.236770183465244 1181 25237002 SGTC_559 1550-0661 158 µM 0.713633478425468 0.259241423944476 no 944 0.237726925140607 1168 5830875 SGTC_1986 st071812 45 µM 0.712816760953058 0.259483612956198 no 945 0.237979576280004 1114 11838594 SGTC_3275 9138069 49.47 µM 0.712799715082645 0.259488668975128 no 946 0.237984850979154 1158 17617007 SGTC_417 st075190 100 µM 0.71112156561136 0.25998667810708 no 947 0.23850445363304 1173 222757 SGTC_867 0518-0118 155 µM 0.709989025099581 0.260323050190208 no 948 0.238855470983995 1209 6848158 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.709523790351407 0.260461292953443 no 949 0.238999746748012 1198 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_2758 dehydroepiandrosterone 69.35 µM 0.708871963995884 0.260655044286376 no 950 0.239201967279935 1173 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_447 ml7 120 µM 0.707663820016712 0.261014353640797 no 951 0.23957702513435 1206 4216 Selective myosin light chain kinase inhibitor. SGTC_1698 5-fluorocytosine 1.055 µM 0.707454979871531 0.261076489772877 no 952 0.239641890279023 1193 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2465 5809242 33.21 µM 0.706282356827487 0.261425521036735 no 953 0.240006281552485 1179 2731748 SGTC_14 0354-0009 295 µM 0.703771236495967 0.262173761204507 no 954 0.240787624543456 1225 1713507 SGTC_3184 9108758 49.47 µM 0.703096984398884 0.262374855256539 no 955 0.240997655672992 1187 902885 SGTC_2084 5306078 60.6385 µM 0.70305462098538 0.262387492678596 no 956 0.24101085530268 1132 679340 SGTC_1235 benzylparaben 21.5 µM 0.702165903628125 0.262652677625932 no 957 0.241287853254332 1164 7180 SGTC_1365 1672-3266 55.4 µM 0.702097551923045 0.262673078813025 no 958 0.241309164470063 1189 6415873 SGTC_2434 5670830 169.91 µM 0.701295957235667 0.262912394246572 no 959 0.241559168087698 1172 1549830 SGTC_582 0987-0078 156 µM 0.700831629038287 0.263051070017766 no 960 0.241704048384957 1242 1625765 SGTC_2129 girgensonine 121.053 µM 0.700818066992095 0.263055121006018 no 961 0.241708280741343 1226 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_271 rotenone 740 µM 0.699816029211648 0.26335451823992 no 962 0.242021101524105 1236 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_1432 4049-0298 68.4 µM 0.699265895930251 0.263518965618075 no 963 0.242192937992582 1204 741646 SGTC_2855 9016525 58.44 µM 0.698885334726975 0.263632754693955 no 964 0.242311846591267 1222 43811474 SGTC_1495 4469-0029 237 µM 0.698808788204365 0.263655645388638 no 965 0.242335767826159 1221 793680 SGTC_1072 oxiconazole 14.9 nM 0.698676535142726 0.263695197117834 no 966 0.242377100694773 1187 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_2222 6885208 172.143 µM 0.69860567690444 0.263716389296528 no 967 0.242399247494549 1153 609514 SGTC_81 0411-0046 9.971 µM 0.697859065067996 0.263939737662374 no 968 0.242632668252491 1095 12925265 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM 0.697656771246321 0.264000270302801 no 969 0.242695934350743 1209 115019 SGTC_849 0386-0493 241 µM 0.696895135465609 0.264228239001551 no 970 0.242934211154811 1154 726119 SGTC_1381 2324-0066 62.1 µM 0.695606431034014 0.264614195225129 no 971 0.243337668806861 1176 10885928 SGTC_3347 9188721 44.724 µM 0.694823399598355 0.264848846587448 no 972 0.243582990996718 1189 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_2853 9015042 58.44 µM 0.693074509352512 0.265373318934195 no 973 0.244131396808614 1147 6457456 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.691500334052584 0.265845846585939 no 974 0.244625585430967 1195 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2217 6934799 96.0675 µM 0.689629412864522 0.266408003884934 no 975 0.245213632897927 1170 675606 SGTC_1397 3532-0190 20.1 µM 0.689553672172337 0.266430774416076 no 976 0.245237454880223 1137 5322280 SGTC_1956 st077085 54 µM 0.688229585539946 0.266829004185568 no 977 0.245654107886825 1225 24208685 SGTC_1607 st000305 50.6 µM 0.685494142760214 0.267652662131335 no 978 0.246516077731881 1212 5457690 SGTC_1261 0712-0010 12.7 µM 0.683865944450377 0.268143529910634 no 979 0.247029910253095 1228 2840123 SGTC_2461 5755302 26.15 µM 0.682911267139961 0.268431555735265 no 980 0.247331456936643 1212 2788904 SGTC_2790 5423970 71.43 µM 0.68271689621277 0.268490216434029 no 981 0.247392875508351 1228 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_415 dibenzyl ketone 100 µM 0.68133496424193 0.268907466033487 no 982 0.247829782141196 1203 7593 SGTC_3088 9117578 49.47 µM 0.681278409670547 0.268924548605139 no 983 0.247847670999949 1275 678341 SGTC_393 acivicin 6.25 µM 0.680341459124883 0.269207638141696 no 984 0.248144139467888 1140 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_519 k048-0011 62.8 µM 0.679549613806119 0.269447002191497 no 985 0.248394841360543 1213 6836379 SGTC_2253 7938677 135.83 µM 0.67662518581751 0.270331940467423 no 986 0.249321897565267 1260 2301972 SGTC_3348 9149464 3.537 µM 0.675674839384879 0.27061982983679 no 987 0.249623556978631 1232 1951442 SGTC_679 0422-0091 41.4 µM 0.675499637232608 0.270672920707471 no 988 0.249679190886599 1243 627384 YHR062C RPP1 SGTC_1461 k072-0203 53.8 µM 0.675252729160397 0.270747749191034 no 989 0.249757605559254 1181 5418714 SGTC_1708 st033234 31.827 µM 0.675208519960272 0.270761148414993 no 990 0.24977164718497 1275 674664 SGTC_101 0490-5701 117.494 µM 0.674008385090815 0.271125019853524 no 991 0.250152991382412 1147 4661669 SGTC_2423 st077119 87.2 µM 0.673198394417721 0.271370740397968 no 992 0.250410541265332 1196 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.672538433774169 0.27157102951155 no 993 0.250620490488654 1231 4330530 SGTC_488 nitrendipine 139 µM 0.669778185766052 0.272409524371863 no 994 0.251499600782784 1265 4507 Dihydropyridine L-type calcium channel blocker. SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.669148373094051 0.272601025851388 no 995 0.251700417642207 1238 688664 SGTC_3106 9121286 49.47 µM 0.668991113242231 0.272648852865341 no 996 0.251750573426616 1263 15943471 SGTC_320 4092-0846 5.34 µM 0.667366068794566 0.273143316975974 no 997 0.252269167029639 1221 1359356 SGTC_1357 1503-1303 39.5 µM 0.666317489431941 0.273462611563501 no 998 0.252604094499742 1248 292895 SGTC_3279 9140807 49.47 µM 0.66542415886315 0.273734778256393 no 999 0.252889618520484 1272 45595718 SGTC_501 nsc-95397 161 µM 0.664409289978176 0.274044135915465 no 1000 0.253214194295949 1272 262093 SGTC_22 0964-0034 14.468 µM 0.66399053658003 0.274171832853244 no 1001 0.253348183991536 1221 138402 SGTC_1962 st076595 64.5 µM 0.663459670951115 0.274333760140552 no 1002 0.253518100109217 1269 279619 SGTC_2830 7992007 71.43 µM 0.662752652972244 0.274549491585328 no 1003 0.253744490897904 1200 1952075 SGTC_1865 st057639 52.2 µM 0.661193049299558 0.275025667099443 no 1004 0.254244259099457 1246 688818 SGTC_411 enrofloxacin 100 µM 0.660502132720272 0.275236746522626 no 1005 0.2544658251581 1314 71188 A bacterial gyrase inhibitor. SGTC_340 k038-0059 454 µM 0.658694417977396 0.27578939192167 no 1006 0.255046009103789 1249 23733424 SGTC_2957 9076800 11.52 µM 0.657911332991139 0.276028961858027 no 1007 0.255297553963877 1199 16459615 SGTC_1631 benzylvanillin 81.9 µM 0.656167983436619 0.276562673158044 no 1008 0.255858023232015 1272 75506 SGTC_276 colchicine 750 µM 0.654948874612494 0.276936193037799 no 1009 0.256250335609318 1293 2833 A microtubule depolymerizer. SGTC_1877 wortmannin 25 µM 0.654238311670284 0.277154014621527 no 1010 0.256479141178698 1256 312145 A covalent inhibitor of PI 3-kinase. SGTC_2232 chlorophetanol 41.5365 µM 0.653343967010739 0.277428293202817 no 1011 0.256767276791436 1321 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2038 4100038 30.985 µM 0.653028138519357 0.277525183516905 no 1012 0.256869069122926 1256 3596803 SGTC_1314 1222-0010 41.1 µM 0.651871779233755 0.277880074114521 no 1013 0.257241945808019 1262 3526027 SGTC_483 fpl-64176 144 µM 0.651197686139189 0.278087057737986 no 1014 0.257459441909432 1281 3423 SGTC_2110 5483698 200 µM 0.649443877221408 0.278625925571645 no 1015 0.25802575554969 1267 2848765 YHR062C RPP1 SGTC_228 caffeine 993.056 µM 0.646594478521508 0.279502502343635 no 1016 0.258947216234286 1268 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_2611 pyromycin 23.93 µM 0.643435565406034 0.280475859338977 no 1017 0.259970756076063 1256 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_870 0573-2213 57.6 µM 0.642494488291919 0.28076615064578 no 1018 0.260276083437625 1269 3916321 SGTC_200 k038-0079 37.545 µM 0.638968184677984 0.281855189598856 no 1019 0.26142181462646 1267 3436683 SGTC_3188 9110789 49.47 µM 0.635020856516402 0.283076664169418 no 1020 0.262707406233032 1316 849217 SGTC_2962 9082311 13.18 µM 0.632711668420127 0.283792402984985 no 1021 0.263460974325932 1271 16459453 SGTC_1731 st035964 63 µM 0.629318423837598 0.284845717307686 no 1022 0.264570306014358 1324 6739575 SGTC_3043 9092303 49.47 µM 0.628845707435964 0.284992603505343 no 1023 0.264725036526666 1248 25236084 SGTC_1281 0884-0031 11.8 µM 0.628073497702199 0.285232628318952 no 1024 0.264977896761532 1305 1548255 SGTC_590 k048-0076 22.4 µM 0.626579996539974 0.285697124193315 no 1025 0.26546729199061 1347 6832814 SGTC_2256 7954252 200 µM 0.624856614281656 0.286233562503057 no 1026 0.266032584753189 1254 2972920 SGTC_1672 st016598 6.51 µM 0.622108353178506 0.287090003758734 no 1027 0.266935311349735 1276 4665860 YNL267W PIK1 SGTC_2829 7992743 58.44 µM 0.618550131174179 0.288200652473828 no 1028 0.268106381443688 1314 16462845 SGTC_1241 0364-0022 50.8 µM 0.615550885217704 0.289138396111097 no 1029 0.269095487694158 1351 4563895 SGTC_2727 riluzole 51.77 µM 0.615351025680877 0.28920093510853 no 1030 0.269161463383471 1318 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_662 k832-1615 104 µM 0.613053401176684 0.289920352072056 no 1031 0.269920515313636 1340 5878478 SGTC_2785 7756463 72.73 µM 0.612607954433353 0.290059924472657 no 1032 0.270067798686542 1290 2201551 SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.610634885175379 0.290678527196584 no 1033 0.270720661220803 1363 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_3248 9135562 49.47 µM 0.609319243902142 0.291091353690432 no 1034 0.271156427001111 1356 17650701 SGTC_1349 flufenamic acid 69 µM 0.609202134223756 0.291128114041231 no 1035 0.271195232931911 1292 3371 A non-steroidal anti-inflammatory. SGTC_2565 isoliquiritigenin 100 µM 0.607682719382532 0.291605249876807 no 1036 0.271698963168386 1278 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_752 1896-0090 130 µM 0.607346625510348 0.291710841328736 no 1037 0.271810450941604 1336 772567 SGTC_210 3551-0445 56.827 µM 0.607278062788139 0.291732384038746 no 1038 0.271833197100786 1367 2865180 YOR207C RET1 SGTC_1345 1488-0192 31.4 µM 0.605156282635487 0.292399422911175 no 1039 0.272537580231488 1337 658348 SGTC_641 4092-0595 30 µM 0.602622169607987 0.29319701767358 no 1040 0.273380034316598 1353 786260 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.59940844947507 0.294209962395069 no 1041 0.274450271913261 1347 1609 A potent and irreversible inhibitor of serine proteases. SGTC_755 1995-0008 37.3 µM 0.599360791280371 0.294224996121895 no 1042 0.274466158658001 1332 689533 SGTC_184 1494-0393 24.714 µM 0.598067605509577 0.294633065588994 no 1043 0.274897412173031 1317 3090647 SGTC_1484 3473-2379 286 µM 0.590246765711593 0.297106505185504 no 1044 0.277512611651917 1432 671917 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM 0.589956848204045 0.297198377503775 no 1045 0.277609789989185 1391 676296 Flavone; oxidizing agent. SGTC_2414 st077232 92.9 µM 0.589875256308068 0.297224235602143 no 1046 0.277637142024276 1312 729801 SGTC_3263 9137018 49.47 µM 0.589854640654922 0.297230769276323 no 1047 0.277644053213928 1284 43844957 SGTC_1789 tunicamycin 25 nM 0.588686105000306 0.297601218001364 no 1048 0.278035930329583 1339 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_2259 7964009 200 µM 0.588511812614239 0.297656490162047 no 1049 0.278094403695522 1374 313134 SGTC_731 3966-0296 387 µM 0.588203345487985 0.297754323727052 no 1050 0.278197906056259 1374 660956 SGTC_37 0566-0070 1.56 µM 0.585749437635505 0.298533128130054 no 1051 0.279021953194481 1390 1626686 SGTC_860 0443-0016 25.1 µM 0.58446218364507 0.298942038141583 no 1052 0.279454700321636 1370 5337942 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.583085265263574 0.299379712390692 no 1053 0.279917951198638 1410 5377381 SGTC_293 4049-0273 38.5 µM 0.581401668331486 0.299915263558579 no 1054 0.280484886662033 1310 1380311 SGTC_2377 9073351 62.6 µM 0.581124085089547 0.300003604243923 no 1055 0.280578413558522 1337 7337946 YHR072W ERG7 SGTC_324 1315-0088 19.6 µM 0.580521661616242 0.30019536561063 no 1056 0.280781441678946 1321 6787421 SGTC_1522 st012842 45.6 µM 0.58017099151227 0.30030701522467 no 1057 0.280899656849215 1299 3491067 YOR116C RPO31 SGTC_244 nsc-207895 1.295 µM 0.580026577890873 0.300353000433913 no 1058 0.280948347435885 1285 42640 SGTC_1065 prochlorperazine maleate 2.48 µM 0.574419233753619 0.302140985223462 no 1059 0.282842070266535 1398 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_656 4090-1979 187 µM 0.57434994495057 0.302163108844769 no 1060 0.28286550890693 1407 22330961 SGTC_2986 9022445 71.43 µM 0.573465435170015 0.302445592936099 no 1061 0.283164798007515 1386 6459286 SGTC_1233 0325-0408 14.2 µM 0.573335147351793 0.302487212696124 no 1062 0.283208895966895 1429 12874 SGTC_688 0527-0193 473 µM 0.572940360076223 0.302613341095723 no 1063 0.283342538035599 1398 4007154 SGTC_663 1486-0733 13.9 µM 0.572054190109233 0.302896544416681 no 1064 0.283642631402231 1372 722445 YPR165W RHO1 SGTC_2735 sertaconazole 140 nM 0.571551555772713 0.303057229649334 no 1065 0.283812911571926 1446 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_19 0279-0214 38.434 µM 0.57155063683544 0.30305752345577 no 1066 0.283813222930121 1419 3566274 YBR002C RER2 SGTC_735 3076-0345 636 µM 0.569540658748695 0.303700466690751 no 1067 0.284494643221698 1466 2888990 SGTC_1425 4048-4433 7.33 µM 0.56922357035333 0.303801951148038 no 1068 0.284602213464169 1418 23734946 SGTC_2880 9042983 58.44 µM 0.568956876744072 0.303887318415745 no 1069 0.284692702626667 1384 6464714 SGTC_769 0302-0231 76 µM 0.567727379588554 0.304281012473912 no 1070 0.285110048614559 1399 571869 YER009W NTF2 SGTC_1404 3909-7820 48.3 µM 0.565679604562791 0.304937228806302 no 1071 0.285805801156303 1387 23741373 SGTC_1252 0493-0875 34.8 µM 0.564847303293554 0.305204122096517 no 1072 0.286088814639045 1384 3960963 SGTC_2516 gossypol 71.55 µM 0.564174895984625 0.305419818012724 no 1073 0.286317555404682 1457 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2145 5634607 200 µM 0.563800814192768 0.30553984583778 no 1074 0.286444848820288 1361 308662 SGTC_2058 5236698 133 µM 0.561889588772527 0.306153407313138 no 1075 0.287095623780358 1395 766665 SGTC_3177 9107506 49.47 µM 0.556299210372177 0.307951207713466 no 1076 0.289003163439435 1366 8897194 SGTC_1310 1188-0297 994 nM 0.555310589375729 0.308269618559383 no 1077 0.289341118501612 1372 1588352 SGTC_2541 muurolladie-3-one 83.07 µM 0.554685417242109 0.308471045844561 no 1078 0.289554926217944 1416 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_2594 a-mangostin 100 µM 0.553930067768597 0.308714492528949 no 1079 0.2898133532642 1483 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_36 0335-0881 14.2 µM 0.553788213536287 0.308760221069586 no 1080 0.289861897792679 1383 23828853 SGTC_1828 st055811 49 µM 0.553271197639003 0.308926912904107 no 1081 0.290038860234105 1386 5877589 SGTC_1334 1486-0610 236 µM 0.552850076409944 0.309062716290744 no 1082 0.290183037589264 1427 3742339 SGTC_803 4488-1585 147 µM 0.551916843429915 0.309363758717149 no 1083 0.290502663914077 1383 747204 SGTC_336 4111-0029 111 µM 0.550455038931357 0.309835565048954 no 1084 0.291003653514576 1365 3131175 SGTC_1706 st031321 9.9705 µM 0.549678068745584 0.310086464536845 no 1085 0.291270100906674 1466 6103185 SGTC_369 0957-0393 4.5 µM 0.548557548010924 0.310448459232168 no 1086 0.291654562941276 1371 6997992 SGTC_2643 anethole 100 µM 0.54819838721143 0.3105645283724 no 1087 0.291777844700741 1403 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_998 3996-0085 177 µM 0.546527562499224 0.311104732635922 no 1088 0.292351673386762 1503 715391 SGTC_162 k030-0015 37.8 µM 0.545749254153419 0.311356511224295 no 1089 0.292619154951096 1506 1809920 YMR134W ERG29 SGTC_1605 st000082 49.1 µM 0.545501974649693 0.311436523303808 no 1090 0.292704161398069 1485 1114022 SGTC_3349 9149703 23.001 µM 0.544968760066555 0.311609085531344 no 1091 0.292887501808967 1384 4910494 SGTC_2762 leflunomide 42.06 µM 0.544333180273003 0.311814829888615 no 1092 0.2931061090628 1442 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_1615 st002656 86.5 µM 0.543866184912036 0.311966039004143 no 1093 0.293266780023605 1401 1584458 SGTC_283 0987-0079 11.7 µM 0.543716982409236 0.312014356183955 no 1094 0.29331812213423 1444 411556 SGTC_2097 5376186 200 µM 0.541731880014999 0.312657511847629 no 1095 0.294001612268986 1462 742755 SGTC_3025 9087895 49.47 µM 0.540163654244693 0.313166006937589 no 1096 0.294542087779788 1448 17173641 SGTC_1982 st072467 71.9 µM 0.539838581876628 0.313271455727819 no 1097 0.294654178516042 1415 3163533 SGTC_3272 9137413 49.47 µM 0.539074020521293 0.313519528587675 no 1098 0.294917890404796 1341 17614870 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.538537113317118 0.313693786239643 no 1099 0.2951031449898 1381 6312947 SGTC_669 0108-0021 26.2 µM 0.538184715546111 0.313808182438253 no 1100 0.295224765520697 1685 17201 SGTC_2273 7815444 169.05 µM 0.538077162039456 0.313843100278219 no 1101 0.295261889290979 1523 2824616 SGTC_2082 5219693 150 µM 0.53791292130816 0.313896425155677 no 1102 0.295318583686356 1400 2834649 SGTC_318 1488-0629 67.2 µM 0.535012524534375 0.314838751371589 no 1103 0.296320598349864 1407 3662576 SGTC_2588 indole-3-carbinol 100 µM 0.53233761769847 0.315708886995231 no 1104 0.297246091327031 1510 3712 Induces cell cycle arrest. SGTC_1102 cgs 12066b 26.1 µM 0.531204411882515 0.316077822582013 no 1105 0.297638568007487 1439 6438352 A 5-HT1B full agonist. SGTC_907 3448-6986 75.5 µM 0.531091519084086 0.31611458691001 no 1106 0.297677680466761 1525 590582 SGTC_1781 st038725 66.3 µM 0.530516027699645 0.316302027951015 no 1107 0.297877099716554 1441 4270275 YIL048W NEO1 SGTC_801 0866-0028 10.1 µM 0.527621953437484 0.31724536038977 no 1108 0.298880876335794 1451 6849771 SGTC_327 1273-0057 3.96 µM 0.527338540707493 0.317337803637506 no 1109 0.298979257366088 1404 3108138 SGTC_902 1120-0002 2.07 µM 0.526138772312826 0.317729268929828 no 1110 0.299395895653889 1397 3280475 SGTC_1893 st059353 36.1 µM 0.526127362569715 0.317732992726186 no 1111 0.299399859128683 1397 3112488 SGTC_2580 diallyl disulphide 81.36 µM 0.523989162483898 0.318431161930201 no 1112 0.300143038857814 1470 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_3332 9141069 11.198 µM 0.523782415718822 0.318498703534598 no 1113 0.300214942577153 1396 17332883 SGTC_3257 9139206 32.98 µM 0.52368324665537 0.318531102978673 no 1114 0.30024943499518 1438 4910041 SGTC_2730 imipramine 71.33 µM 0.523127639496091 0.318712650602509 no 1115 0.300442716234159 1475 3696 A tricyclic antidepressant. SGTC_1135 dihydrocapsaicin 536.708 nM 0.522734256684408 0.318841216867473 no 1116 0.300579597829859 1384 107982 A Capsaicinoid. SGTC_2190 6049624 200 µM 0.520181378853403 0.319676083516817 no 1117 0.301468581355685 1455 2265554 SGTC_3322 9139058 2.11 µM 0.519820359316645 0.31979422150374 no 1118 0.301594393903849 1508 4908926 YPR165W RHO1 SGTC_3121 9125696 49.47 µM 0.519415016969248 0.319926885223496 no 1119 0.301735680751331 1500 1235365 SGTC_2905 7799065 20.05 µM 0.518549559905391 0.32021021608163 no 1120 0.302037445549834 1502 1296806 SGTC_950 1165-0508 94.1 µM 0.516584498352044 0.320853921461005 no 1121 0.302723119609307 1428 6148369 SGTC_43 0570-0105 72.5 µM 0.51438691945903 0.321574432110562 no 1122 0.303490751332597 1508 1114046 YDL195W SEC31 SGTC_1403 3909-7815 62.9 µM 0.513556965447003 0.321846720424731 no 1123 0.30378088686268 1492 6615483 SGTC_2119 5528445 120.635 µM 0.513485491487422 0.321870173820536 no 1124 0.303805878534003 1515 791935 SGTC_2134 5324836 1.464 µM 0.512510142952389 0.322190294627719 no 1125 0.304147011706526 1517 699272 SGTC_1296 1068-0102 11.9 µM 0.511419549196489 0.322548396514374 no 1126 0.304528654465651 1505 767053 SGTC_3095 9117207 49.47 µM 0.511038036899239 0.322673706873833 no 1127 0.304662211299244 1466 17015229 SGTC_945 3381-0768 11.3 µM 0.510902498025099 0.32271823040658 no 1128 0.304709665955611 1463 1126236 YIL048W NEO1 SGTC_2282 7944268 200 µM 0.510675594958847 0.322792772099733 no 1129 0.304789116253754 1539 2970414 SGTC_316 k060-0003 58.6 µM 0.510035629813998 0.323003050388522 no 1130 0.305013250176438 1489 6152314 SGTC_2279 7948423 32.93 µM 0.507544946751242 0.323821971510071 no 1131 0.305886253856048 1619 1247112 SGTC_1675 st018485 24.5 µM 0.504640905255484 0.324777880140278 no 1132 0.30690553698613 1492 3323024 SGTC_452 diindolylmethane 8 µM 0.504078203100664 0.324963235742701 no 1133 0.307103211662916 1485 3071 Inhibits expression of several cancer promoting factors. SGTC_975 1335-0046 28.5 µM 0.502924631224892 0.325343360865751 no 1134 0.30750863142241 1410 16486740 SGTC_2053 5265679 138 µM 0.50286948453914 0.325361537363151 no 1135 0.307528018473817 1427 764595 SGTC_1118 chelidonine 707.474 nM 0.500578850449516 0.326116903146787 no 1136 0.308333775053306 1584 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_2286 7945697 125 µM 0.498891065366313 0.326673928869923 no 1137 0.308928064336965 1417 1245733 SGTC_3077 9117319 49.47 µM 0.49753980705278 0.327120168198932 no 1138 0.309404219427004 1492 17154678 SGTC_524 r073-0010 27.8 µM 0.497520478405717 0.327126553083398 no 1139 0.309411032761481 1425 2772106 SGTC_523 1934-0222 13.7 µM 0.497280553779255 0.327205812247975 no 1140 0.309495611477046 1460 1361595 SGTC_2745 rifampicin 24.3 µM 0.496827791453163 0.327355403628826 no 1141 0.309655247657906 1560 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_716 1683-5115 658 µM 0.495096344601343 0.327927724336552 no 1142 0.310266056991793 1490 723597 SGTC_2427 5545055 42.75 µM 0.494793932237658 0.328027726677353 no 1143 0.310372793968603 1532 5372858 SGTC_2529 gangaleoidin 93.61 µM 0.493880880703667 0.32832973121667 no 1144 0.310695153999244 1521 4565183 SGTC_1695 st026914 34.495 µM 0.491446184415024 0.329135589150609 no 1145 0.311555452912042 1454 3289191 SGTC_3343 9148379 18.9835 µM 0.490204238848922 0.329546965902298 no 1146 0.311994690802383 1633 1955036 SGTC_2858 9025781 8.96 µM 0.489543400007611 0.329765943488675 no 1147 0.312228518210995 1520 4894980 YPL153C RAD53 SGTC_3193 9111931 49.47 µM 0.486583339504495 0.330747513530032 no 1148 0.313276816288543 1530 17087244 SGTC_1941 st076221 61.8 µM 0.485273176353786 0.331182342168165 no 1149 0.313741290123506 1502 2828568 SGTC_502 l-744,832 89.3 µM 0.4850267119368 0.331264166447134 no 1150 0.313828698739657 1581 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_217 ketoconazole 989 nM 0.484283535809778 0.331510943930861 no 1151 0.314092329428996 1454 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_2993 9054257 71.4286 µM 0.482901335730821 0.331970108852471 no 1152 0.314582896668213 1476 6470217 YGL055W OLE1 SGTC_3318 9139014 38.6185 µM 0.481925316258338 0.332294493272282 no 1153 0.31492950058067 1500 16643984 SGTC_337 1315-0038 354 µM 0.480416991302038 0.332796038908926 no 1154 0.315465457384498 1502 1626437 SGTC_2927 9011802 47.9 µM 0.479999239337503 0.33293500205284 no 1155 0.315613966956533 1445 43912568 SGTC_1144 3486-0183 12.5 µM 0.479732141733801 0.33302386278989 no 1156 0.315708934964113 1508 6744069 SGTC_1530 rhein 70.4 µM 0.477092981205049 0.333902388836809 no 1157 0.316647956221764 1526 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_1896 st058441 89 µM 0.475998516962467 0.334266982606421 no 1158 0.317037717228901 1460 688759 SGTC_1493 4348-0038 111 µM 0.475892759356392 0.334302221437348 no 1159 0.317075390433243 1560 800424 SGTC_3191 9110352 49.47 µM 0.475405399830168 0.334464630325477 no 1160 0.317249023200042 1550 17122424 SGTC_95 0471-0001 561.058 µM 0.475183739657462 0.334538507159767 no 1161 0.317328007923253 1426 4015405 SGTC_1006 4099-6547 255 µM 0.474637271016868 0.334720666354884 no 1162 0.317522767992493 1548 3146833 SGTC_255 tunicamycin 200.472 nM 0.473567726898485 0.335077299448436 no 1163 0.317904097030472 1546 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1316 1272-0050 65.9 µM 0.473370350961646 0.33514312954126 no 1164 0.317974489424587 1510 7340392 SGTC_677 0929-0063 136 µM 0.47331603892219 0.335161244930754 no 1165 0.317993860490405 1482 1539583 SGTC_268 camptothecin 39.6153 µM 0.473098673535152 0.335233749427086 no 1166 0.318071391549068 1531 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_2778 tioconazole 65.09 nM 0.471197424338037 0.335868192378965 no 1167 0.318749878930242 1475 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_713 1488-1073 324 µM 0.470128904781139 0.336224960714955 no 1168 0.319131462125206 1530 3312542 SGTC_481 bay k-8644 50 µM 0.466716208105441 0.337365413999479 no 1169 0.320351466000322 1484 2303 A calcium channel antagonist. SGTC_1201 1889-3372 45.9 µM 0.466672517896954 0.337380024090599 no 1170 0.320367097430892 1518 5392199 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.466016190540458 0.337599530738117 no 1171 0.320601955790631 1493 23665772 A membrane-active detergent. SGTC_1571 st070080 73.4 µM 0.46489602089533 0.337974295618756 no 1172 0.321002960092197 1634 4315245 SGTC_2814 7977482 42.97 µM 0.463208149295546 0.338539294656612 no 1173 0.32160758774013 1652 6456762 SGTC_3245 9134821 49.47 µM 0.462523040398054 0.338768732198218 no 1174 0.321853141762165 1460 17014901 SGTC_248 streptozotocin 5.23457 mM 0.462487223110407 0.338780728770699 no 1175 0.321865981394202 1620 5300 DNA alkylating agent. SGTC_2224 6650123 117.647 µM 0.462389969305311 0.338813303595407 no 1176 0.321900845605804 1534 2908370 SGTC_2472 5377652 49.4 µM 0.462138312473426 0.338897600773653 no 1177 0.321991068551173 1506 1610903 SGTC_708 3448-5400 146 µM 0.461623485896483 0.339070076728712 no 1178 0.322175674689903 1515 3462195 SGTC_954 1189-0853 2.85 µM 0.461537271675825 0.339098963307036 no 1179 0.322206593612567 1509 2828194 SGTC_259 usnic acid 108.925 µM 0.460823175939699 0.33933826160584 no 1180 0.322462736357945 1581 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_939 1165-0479 45.3 µM 0.460744398888559 0.339364664297829 no 1181 0.322490998476542 1525 1377347 SGTC_2808 7946468 45.46 µM 0.458548394717818 0.340100987785827 no 1182 0.323279251083063 1581 2970879 SGTC_73 0327-0325 16.231 µM 0.458330887933528 0.340173951396902 no 1183 0.323357368110578 1628 53298 SGTC_2699 st077704 54.6 µM 0.457859806494736 0.34033199826136 no 1184 0.323526582548008 1552 645852 SGTC_2098 5376439 882.5 nM 0.455718523024289 0.341050747683434 no 1185 0.324296200192461 1641 2844116 SGTC_1115 galangin 695.678 nM 0.455248541307091 0.341208580446723 no 1186 0.324465221135378 1593 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_3249 9135183 49.47 µM 0.455070414348631 0.34126840763198 no 1187 0.324529290923999 1570 4902779 SGTC_2320 7373003 200 µM 0.45473276880387 0.341381822990103 no 1188 0.324650751580448 1471 5415828 SGTC_408 cantharidin 100 µM 0.452883327796458 0.342003305351544 no 1189 0.32531637840868 1561 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1038 k292-0204 154 µM 0.452376878031018 0.342173566467058 no 1190 0.325498750597466 1496 4454212 SGTC_2714 st079313 56.9 µM 0.449788732484077 0.343044164114433 no 1191 0.326431391543894 1550 2939799 SGTC_3098 9119039 49.47 µM 0.449112337472436 0.343271826779912 no 1192 0.326675310446095 1547 17161528 SGTC_1347 1493-0251 600 nM 0.448561794473692 0.343457171872198 no 1193 0.326873899803574 1665 3986378 SGTC_751 0833-0568 350 µM 0.448349241159381 0.343528739871678 no 1194 0.326950584191264 1603 6954252 SGTC_2162 5663267 200 µM 0.447571764098635 0.343790568918614 no 1195 0.327231142416623 1647 6456493 SGTC_2818 7996756 12.99 µM 0.447072450681753 0.343958761004257 no 1196 0.327411374777675 1522 2241621 SGTC_1219 1469-0211 33.1 µM 0.44654313809451 0.344137091931806 no 1197 0.327602479586413 1609 6822282 SGTC_2875 9039966 71.43 µM 0.446200824495346 0.344252439413725 no 1198 0.327726093704633 1669 6463691 SGTC_2951 9072950 58.06 µM 0.445528783464346 0.344478935427692 no 1199 0.327968831817341 1565 16488155 SGTC_1096 rimcazole 32.2 µM 0.443511299974319 0.345159216733377 no 1200 0.328697973827022 1550 18528119 A dopamine reuptake inhibitor. SGTC_1217 1183-1422 255 µM 0.441818427788807 0.345730427819966 no 1201 0.329310301261658 1654 2849664 SGTC_432 NS 1619 61.3 µM 0.441665183445276 0.345782153083454 no 1202 0.32936575378496 1586 4552 A K+/calcium channel activator. SGTC_442 cape 100 µM 0.43952481675182 0.346504901334035 no 1203 0.330140652074417 1679 5281787 SGTC_714 4296-0578 26.1 µM 0.439067966597681 0.346659240695085 no 1204 0.330306144635679 1648 1589775 SGTC_157 1348-1695 65.819 µM 0.438755496328645 0.346764818331297 no 1205 0.330419355148972 1548 5380510 SGTC_2204 7233102 200 µM 0.438635839083446 0.346805251342517 no 1206 0.330462712050167 1587 2172480 SGTC_2963 9082507 9 µM 0.438003386558183 0.347018990400399 no 1207 0.330691914247268 1628 16459611 SGTC_841 0251-0215 91.2 µM 0.437986196937499 0.347024800359482 no 1208 0.330698144690662 1606 3888614 SGTC_835 0312-0010 67.2 µM 0.437448635343018 0.347206510168873 no 1209 0.330893009598212 1567 1626196 SGTC_1583 clindamycin 39.6 µM 0.43623102347491 0.34761822452144 no 1210 0.33133456064416 1494 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_2484 5809818 12.04 µM 0.435209505003247 0.347963772014028 no 1211 0.331705181969231 1590 2870548 SGTC_1958 st076513 41.9 µM 0.432173810948361 0.348991395986905 no 1212 0.332807546019103 1529 732122 YGL099W LSG1 SGTC_1992 st073643 23.3 µM 0.429916953874622 0.349756091864522 no 1213 0.333628026139996 1588 3161292 SGTC_3286 9117135 37.221 µM 0.429668407253358 0.349840344805284 no 1214 0.333718433983605 1516 3438150 SGTC_2327 6189656 200 µM 0.428216182131268 0.350332771331026 no 1215 0.334246867962129 1701 5349088 SGTC_3240 9133527 49.47 µM 0.427458164186858 0.350589903231194 no 1216 0.334522825272889 1570 17617455 SGTC_1211 1056-0033 32.3 µM 0.425046437856309 0.351408454640087 no 1217 0.335401411316133 1648 6741922 SGTC_1528 arabinosylhypoxanthine 74.6 µM 0.424817483920695 0.351486198597192 no 1218 0.335484865577032 1655 804 An inhibitor of viral and cellular DNA polymerases. SGTC_828 2074-0507 139 µM 0.423527995197807 0.351924175362058 no 1219 0.335955038822156 1684 X828 SGTC_13 0199-0087 65 µM 0.42301804652074 0.352097434455624 no 1220 0.336141047163801 1630 4589825 SGTC_1507 4075-3230 155 µM 0.422502933602399 0.35227247931745 no 1221 0.336328979949736 1582 659771 SGTC_3151 9099821 49.47 µM 0.422141562409127 0.352395298591517 no 1222 0.336460846323255 1550 17174189 SGTC_1726 st035556 14.5795 µM 0.420521593765005 0.352946066550458 no 1223 0.337052228991145 1687 5919439 SGTC_2073 5212005 126 µM 0.419806988081299 0.35318912110818 no 1224 0.337313229754705 1606 691789 SGTC_1304 1165-0502 251 µM 0.41953141101354 0.35328286749761 no 1225 0.33741390175123 1620 767425 SGTC_356 1634-0012 32.5 µM 0.41945441680402 0.353309061142028 no 1226 0.337442030848544 1701 735457 SGTC_499 genistein 192 µM 0.418942489479782 0.353483237907233 no 1227 0.33762908168944 1669 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_1925 st057770 10.1 µM 0.418392308368513 0.353670464247996 no 1228 0.337830154639567 1506 5989122 SGTC_3138 9097216 49.47 µM 0.415911100517188 0.354515257221992 no 1229 0.338737528209973 1592 25237486 SGTC_2817 7995342 71.43 µM 0.415483808919929 0.354660812373581 no 1230 0.338893882723455 1509 18879975 SGTC_602 3130-1533 38.1 µM 0.414985769241799 0.354830494356645 no 1231 0.339076160404071 1689 720941 SGTC_2443 5493264 126.67 µM 0.413092204206208 0.355475894128723 no 1232 0.339769530423493 1711 5340055 SGTC_1224 0823-0416 294 µM 0.41287931778048 0.355548479971082 no 1233 0.339847517385331 1675 3598164 SGTC_1244 0416-0015 52.5 µM 0.412703713606686 0.355608357985008 no 1234 0.339911851850777 1596 96201 SGTC_3089 9117425 49.47 µM 0.412361433131845 0.355725080002209 no 1235 0.340037263359933 1540 9401657 SGTC_2552 juarezic acid 87.02 µM 0.412300466683413 0.355745871760181 no 1236 0.340059603314227 1609 1549512 SGTC_1803 st050068 52.4 µM 0.411363339944812 0.35606551974381 no 1237 0.340403065565488 1629 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_2864 9034755 47.6 µM 0.409361730375059 0.356748594708629 no 1238 0.341137109984826 1600 4930451 SGTC_122 0236-0016 402.397 µM 0.408386639057875 0.357081523774154 no 1239 0.341494920482304 1638 6808838 SGTC_433 pimozide 108 µM 0.408344527322184 0.357095904595017 no 1240 0.34151037662796 1512 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_652 0437-0092 114 µM 0.407770720690973 0.357291875191678 no 1241 0.341721005651386 1571 3091274 SGTC_3250 9135583 49.47 µM 0.405364061183606 0.358114224513226 no 1242 0.34260496202659 1701 7699353 SGTC_2018 5133068 143 µM 0.404890264030381 0.35827619749811 no 1243 0.342779087601422 1606 785362 SGTC_2150 5556613 200 µM 0.40429207943017 0.35848073018408 no 1244 0.342998974616922 1638 743190 SGTC_605 1315-0399 119 µM 0.403663458388181 0.358695713525014 no 1245 0.343230107092226 1674 24020461 SGTC_2647 atorvastatin 60.16 µM 0.401996565104448 0.359265994259561 no 1246 0.343843277093606 1677 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_297 0986-0032 24 µM 0.401436773600013 0.359457581628827 no 1247 0.344049289772623 1606 2847425 SGTC_3028 9087778 49.47 µM 0.401162299686034 0.359551532614999 no 1248 0.344150317704364 1551 17217395 SGTC_61 0978-8327 98.565 µM 0.400956137417462 0.359622106465734 no 1249 0.344226208908271 1644 6150059 YHR072W ERG7 SGTC_142 0335-0849 62.6745 µM 0.400847730074128 0.359659218589696 no 1250 0.344266117678931 1651 3889043 YPR107C YTH1 SGTC_1337 1486-1011 40.3 µM 0.400482487554915 0.359784265298273 no 1251 0.344400589782156 1590 X1337 SGTC_2686 alizarin 95.37 µM 0.399229502368153 0.360213359132213 no 1252 0.344862053363006 1563 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_3251 9135047 49.47 µM 0.399168197781125 0.360234357855761 no 1253 0.344884637240693 1728 17682963 SGTC_1013 4112-3890 241 µM 0.397468811879606 0.360816617912708 no 1254 0.345510890452046 1598 705171 SGTC_717 1532-0246 73.2 µM 0.397353797193334 0.360856037034708 no 1255 0.345553290666528 1617 9561992 SGTC_2546 rhodinyl acetate 100 µM 0.396616031159144 0.361108927611772 no 1256 0.345825314499627 1751 6708682 SGTC_881 0833-0569 170 µM 0.396484054588321 0.361154172791659 no 1257 0.345873984357859 1560 5418700 SGTC_1899 st063254 59.6 µM 0.395392972366264 0.361528299992678 no 1258 0.346276447338342 1566 3093813 SGTC_1159 4092-0538 61.2 µM 0.394575072396251 0.361808841093346 no 1259 0.34657825661915 1675 717301 SGTC_1091 telmisartan 47.6 µM 0.393349447189832 0.362229371672095 no 1260 0.347030700913078 1708 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_1340 1486-1359 257 µM 0.393177723421673 0.362288305995551 no 1261 0.347094110846562 1643 4309068 SGTC_92 0063-0024 660.874 µM 0.392749544754416 0.362435267951982 no 1262 0.347252236786987 1645 3594437 SGTC_55 0767-0285 6.563 µM 0.392141095894629 0.362644138155872 no 1263 0.347476982063126 1741 3116166 SGTC_2823 7987624 58.44 µM 0.390932140340935 0.363059273415502 no 1264 0.347923698060759 1630 2239440 SGTC_3002 9075603 71.4286 µM 0.390274431522098 0.363285187332267 no 1265 0.348166813963794 1634 20105405 SGTC_2642 cholecalciferol 100 µM 0.38884943178932 0.363774818183933 no 1266 0.348693765746747 1694 9821465 A vitamin D precursor, similar to steriods. SGTC_3143 9086658 49.47 µM 0.388274678520761 0.36397236681431 no 1267 0.348906386923696 1627 25236626 SGTC_3267 9137951 49.47 µM 0.387976166934838 0.364074982596714 no 1268 0.349016835444536 1678 16643986 SGTC_2723 salbutamol 83.58 µM 0.387512832392164 0.364234276911801 no 1269 0.349188293370736 1713 9884233 β2-adrenoceptor agonist SGTC_124 0136-0217 7.121 µM 0.384716266017083 0.36519623297121 no 1270 0.350223821262466 1726 3976905 SGTC_1635 st007035 42.4 µM 0.38152812872134 0.366293915914981 no 1271 0.351405701536453 1643 3716403 SGTC_1226 3909-7979 35.4 µM 0.381227528452885 0.366397469896637 no 1272 0.351517211986611 1768 6615510 SGTC_2141 5621638 7.665 µM 0.380311111260449 0.366713227059982 no 1273 0.351857244251775 1776 2856238 SGTC_3020 9089140 49.47 µM 0.379468976691777 0.367003469243548 no 1274 0.352169818814208 1651 17217859 SGTC_2589 lobaric acid 100 µM 0.379095056873133 0.367132365317951 no 1275 0.352308638438499 1606 73157 A novel microtubule depolymerizer. SGTC_1208 2323-2347 50.3 µM 0.378997880077928 0.367165866148448 no 1276 0.352344719037762 1771 5412760 SGTC_94 0334-0113 514.748 µM 0.378526961521666 0.367328225427561 no 1277 0.352519584367899 1598 6795178 SGTC_2066 5222451 176 µM 0.378291394347214 0.36740945117 no 1278 0.35260706879718 1611 2281147 SGTC_1937 st074714 47.2 µM 0.375777068488584 0.368276782940319 no 1279 0.353541318577611 1580 17250970 SGTC_1945 st075991 56.6 µM 0.374977276126839 0.368552817142741 no 1280 0.353838683351266 1624 1084980 SGTC_2000 st075254 36.4 µM 0.373922057303253 0.368917111062659 no 1281 0.3542311527584 1635 17234175 SGTC_558 k064-0027 21.3 µM 0.373114525744445 0.369195975323514 no 1282 0.354531604041935 1733 5088526 SGTC_3314 9135860 59.4275 µM 0.371879803374235 0.369622494142199 no 1283 0.354991171512438 1797 25252478 SGTC_2846 9008642 19.48 µM 0.371687933254679 0.369688787604369 no 1284 0.355062605125203 1649 2992898 SGTC_2108 5365811 200 µM 0.371034432719445 0.369914609048595 no 1285 0.355305942837105 1723 780283 SGTC_3185 9108267 49.47 µM 0.370931626920207 0.369950138360235 no 1286 0.355344229018288 1609 4910486 SGTC_932 2857-0803 154 µM 0.370848739470754 0.369978784770643 no 1287 0.355375098416974 1778 674898 SGTC_1912 st060209 90.8 µM 0.370238390776738 0.3701897472239 no 1288 0.355602437033774 1609 688787 SGTC_203 k066-0004 30.888 µM 0.368480308249441 0.370797633357258 no 1289 0.356257562790391 1789 6795412 SGTC_2833 9001315 45.46 µM 0.368410922400232 0.370821631290829 no 1290 0.356283427211597 1670 2989378 SGTC_176 1486-1328 72.834 µM 0.367101700456598 0.371274535601858 no 1291 0.356771579467175 1627 22310231 SGTC_2617 dihydrotanshinone i 20.83 µM 0.366942295500525 0.371329691376473 no 1292 0.356831030723198 1639 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_953 1188-0045 9.7 µM 0.364815987906273 0.372065668247226 no 1293 0.357624384908028 1723 6144426 SGTC_900 1112-0045 141 µM 0.364719876405993 0.372098946298081 no 1294 0.357660259977947 1652 56211 YIL048W NEO1 SGTC_1393 3470-5649 58.2 µM 0.364701962087947 0.372105149132684 no 1295 0.357666946906934 1664 4108395 SGTC_2176 5809774 33.9695 µM 0.362164450092204 0.37298409752904 no 1296 0.358614571795727 1812 2870539 SGTC_1987 st072290 61.9 µM 0.362105748388635 0.373004438587097 no 1297 0.358636504070802 1699 54697379 SGTC_1659 st012954 42.1 µM 0.36103388437228 0.373375918425173 no 1298 0.359037058452695 1720 24207262 SGTC_2682 pyrogallin 40.03 µM 0.360817416853197 0.373450954663935 no 1299 0.35911797095168 1729 822798 An ATP competetive kinase inhibitor. SGTC_2013 4024628 200 µM 0.360815010485558 0.373451788833497 no 1300 0.359118870453415 1715 5230760 SGTC_41 0478-0632 82.643 µM 0.35920374014638 0.374010470132128 no 1301 0.3597213394312 1844 3750424 SGTC_2365 9042475 200 µM 0.357957122021054 0.374442896045123 no 1302 0.36018770094389 1663 6464479 SGTC_216 k038-0035 28.382 µM 0.357444002544513 0.374620932451257 no 1303 0.360379720136183 1767 4444231 YPR107C YTH1 SGTC_2720 fluspirilene 36.88 µM 0.356877301822331 0.374817590935944 no 1304 0.360591831391644 1738 3396 An atypical antipsychotic. SGTC_756 0508-1999 28.3 µM 0.356675748994136 0.374887542361143 no 1305 0.360667281245064 1609 6753853 SGTC_177 1327-0068 8.361 µM 0.356131866143489 0.375076324228581 no 1306 0.360870906943026 1664 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_2294 7971431 200 µM 0.355939895685894 0.375142964369206 no 1307 0.360942788676993 1724 5741572 SGTC_3183 9108214 49.47 µM 0.355765652672805 0.375203453876182 no 1308 0.361008036769948 1731 4974831 SGTC_2039 Aminomethylbenzodioxan 200 µM 0.355573561371928 0.375270143080032 no 1309 0.361079973128215 1678 15053 SGTC_1545 lovastatin 49.4 µM 0.354255762842488 0.375727749564684 no 1310 0.361573608453879 1716 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_2194 5927483 104.545 µM 0.349381424155548 0.377421882074349 no 1311 0.363401488552442 1741 760979 SGTC_2776 terbinafine 19.92 µM 0.348427638726124 0.377753658442971 no 1312 0.363759524350823 1702 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_842 0271-0008 11.1 µM 0.348024627527856 0.377893873903265 no 1313 0.363910844092069 1761 1221709 SGTC_3109 9122853 49.47 µM 0.346789647367421 0.378323647717594 no 1314 0.364374677631136 1748 1234709 SGTC_1120 ficusin 1.78878 µM 0.344384039076616 0.379161232689958 no 1315 0.365278745288216 1814 6199 A DNA cross-linker. SGTC_197 4544-0043 41.561 µM 0.344187551230139 0.379229670978257 no 1316 0.365352621855467 1707 896523 SGTC_1750 st081859 2.357 µM 0.341484294009485 0.380171620496615 no 1317 0.366369513316906 1757 5291695 SGTC_3001 9076041 71.4286 µM 0.341034969124574 0.380328256752624 no 1318 0.366538628255165 1692 16004211 SGTC_31 0508-1974 57.237 µM 0.33870191840106 0.381141881526179 no 1319 0.367417147663707 1784 6810525 SGTC_1071 trifluoperazine 6.31 µM 0.336456708228711 0.381925369392321 no 1320 0.368263246176382 1809 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_2438 5259590 200 µM 0.334642204599064 0.382558911740463 no 1321 0.368947501996154 1844 1201127 SGTC_1134 3477-0009 42.5 µM 0.33356312121954 0.382935827917353 no 1322 0.369354625409388 1889 3973534 SGTC_1666 st014829 29 µM 0.33196882583037 0.383492906830048 no 1323 0.369956399392445 1702 3858230 SGTC_1822 st052468 42 µM 0.331595634600166 0.383623342203428 no 1324 0.370097308169149 1717 2873678 SGTC_138 0850-0259 40.9225 µM 0.331428227727364 0.38368185745156 no 1325 0.3701605229785 1741 6813004 SGTC_620 0109-0052 432 µM 0.330235460821991 0.384098852833417 no 1326 0.370611027258316 1820 493037 SGTC_2896 9052656 71.43 µM 0.328566789885374 0.384682451003292 no 1327 0.37124157669113 1744 6469436 SGTC_528 3492-0019 172 µM 0.327956822471105 0.384895845295126 no 1328 0.371472154664104 1737 2869262 SGTC_1883 5-benzylidenerhodanine 20 µM 0.325273842696935 0.385834886624537 no 1329 0.37248691295189 1854 1273210 SGTC_1449 4112-4002 201 µM 0.325050121285752 0.385913219297441 no 1330 0.372571569112672 1690 2059539 SGTC_2343 7990716 14.84 µM 0.323179979565502 0.386568202861723 no 1331 0.373279471028145 1780 6456862 SGTC_2096 5468907 200 µM 0.321186064005426 0.387266892062188 no 1332 0.374034696219291 1869 759785 SGTC_2297 7971671 152.32 µM 0.317190693172424 0.388668009917527 no 1333 0.375549455685402 1843 909016 SGTC_2824 7998404 51.95 µM 0.31439570044477 0.389649035723334 no 1334 0.376610260635555 1780 837851 SGTC_1039 k821-0043 94 µM 0.311622518159734 0.390623101610632 no 1335 0.377663709407611 1851 15992768 SGTC_2765 myclobutanil 7.74 µM 0.308189962573311 0.391829719597914 no 1336 0.378968894856075 1748 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_331 k048-0133 24.5 µM 0.3079153753492 0.391926288112285 no 1337 0.379073363002634 1749 6813582 SGTC_1670 st016595 4.04 µM 0.304807569004589 0.393019723238205 no 1338 0.380256358227107 1851 597879 SGTC_2502 avocadyne acetate 18.59 µM 0.303610669990112 0.393441059990801 no 1339 0.380712260811019 1739 3952079 SGTC_3117 9124945 49.47 µM 0.302877668253986 0.393699155592576 no 1340 0.380991545318919 1686 17592065 SGTC_1080 nisoldipine 24.4 µM 0.3022865201143 0.393907337470658 no 1341 0.381216826685044 1762 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_2047 4141938 200 µM 0.301976746042301 0.394016441269696 no 1342 0.381334894945197 1787 3807862 SGTC_1178 0988-0033 191 µM 0.301466952063874 0.394196011070177 no 1343 0.381529223459591 1810 5392207 SGTC_1807 st050092 58.9 µM 0.299701245849367 0.394818136955719 no 1344 0.382202524108435 1773 5008496 SGTC_3228 9131799 49.47 µM 0.299556167376419 0.39486926560421 no 1345 0.382257861430016 1801 17015818 SGTC_781 4335-2806 94.4 µM 0.298966604961171 0.395077058188723 no 1346 0.382482763116475 1898 845254 SGTC_2576 guaiol 23.12 µM 0.298757062583599 0.395150919057146 no 1347 0.382562707266466 1930 227829 SGTC_1407 3909-7909 12.3 µM 0.297614212164862 0.395553824692783 no 1348 0.382998813063661 1764 4411780 SGTC_2007 4011539 71.82 µM 0.297420504560922 0.39562212632206 no 1349 0.383072745599685 1726 45595301 SGTC_100 0086-0128 49.5915 µM 0.296104179316365 0.396086349640863 no 1350 0.383575261199988 1683 93297 SGTC_3233 9132340 49.47 µM 0.295922733087576 0.396150351152835 no 1351 0.383644544841985 1741 17682950 SGTC_2285 7945142 200 µM 0.295771867925395 0.396203567939305 no 1352 0.383702154206076 1767 2970608 SGTC_1549 4'-methoxyflavonol 74.6 µM 0.292587930855872 0.397327132443085 no 1353 0.384918570020257 1824 97141 SGTC_1431 4049-0260 9.09 µM 0.291438199486161 0.397733065707578 no 1354 0.38535810143978 1849 3854841 SGTC_102 gallobenzophenone 83.616 µM 0.290781876425152 0.397964842012615 no 1355 0.385609073611172 1883 70837 SGTC_1534 6-azauridine 81.6 µM 0.290605296201727 0.398027206344319 no 1356 0.385676604518661 1796 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_163 TUB2.036 7.546 µM 0.290431855882597 0.398088464265779 no 1357 0.385742937982428 1867 15992207 YJR013W GPI14 SGTC_3303 9125618 40.5795 µM 0.289162818566891 0.398536755813904 no 1358 0.386228391736943 1869 22695467 SGTC_1977 st070720 65.3 µM 0.288957794969493 0.398609193645687 no 1359 0.386306837589975 1794 682188 SGTC_2459 5811157 9.22 µM 0.287449135506197 0.399142332341865 no 1360 0.386884221571258 1847 2870684 YBR192W RIM2 SGTC_1229 0139-0193 12.2 µM 0.286983629908314 0.399306873405928 no 1361 0.387062427352231 1911 3090752 SGTC_3130 9127414 49.47 µM 0.284485575336034 0.400190159212853 no 1362 0.388019143396795 1823 1494646 SGTC_1928 4'-methoxychalcone 40.3 µM 0.284047078878906 0.400345259774944 no 1363 0.388187151047676 1989 641818 SGTC_560 2332-1943 155 µM 0.281941941324844 0.401090086325413 no 1364 0.388994014492734 1807 21177716 SGTC_2671 danthron 100 µM 0.281145203713412 0.401372076984317 no 1365 0.389299515615912 1809 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1632 st005650 90 µM 0.280732659500088 0.401518109637011 no 1366 0.389457728501372 1813 2759605 SGTC_2416 tofa 880 nM 0.279832179967767 0.401836909685235 no 1367 0.389803130776759 1682 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.277915318705188 0.402515760365007 no 1368 0.390538682167792 1902 140250 A respiratory chain inhibitor. SGTC_414 piperonyl butoxide 100 µM 0.2758028410467 0.403264228563266 no 1369 0.391349750740132 1772 5794 A potent inhibitor of cytochrome P450. SGTC_2759 disulfiram 3.38 µM 0.27560200110908 0.403335406301386 no 1370 0.391426886255384 1785 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_696 1560-0013 611 µM 0.275233370860374 0.403466057310931 no 1371 0.391568475201821 1874 1650269 SGTC_1045 1348-1485 165 µM 0.268486061509418 0.405859347604108 no 1372 0.394162601227308 1874 6810614 SGTC_1844 rapamycin 4 nM 0.266735584403398 0.406480826081015 no 1373 0.394836376905442 1844 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_472 calcifediol 10 µM 0.266627342342353 0.406519263419651 no 1374 0.394878050678604 1850 5283731 A vitamin D metabolite. SGTC_1782 st039423 80.636 µM 0.264578759447738 0.407246895675315 no 1375 0.395666992338374 1781 2068169 SGTC_1477 0139-0234 16 µM 0.26396592791654 0.407464628474164 no 1376 0.395903086705978 1882 620880 SGTC_3129 9127257 49.47 µM 0.262443274717053 0.408005735275871 no 1377 0.396489856555617 1718 837894 SGTC_344 k064-0035 6.43 µM 0.26008126205282 0.408845473040463 no 1378 0.397400545707046 1764 5088750 SGTC_1668 st014914 51.6 µM 0.259904929022043 0.408908179426767 no 1379 0.397468554546458 1888 2839556 SGTC_3055 9094636 49.47 µM 0.259734242580983 0.408968880030968 no 1380 0.397534388555025 1893 25236176 SGTC_3110 9122132 49.47 µM 0.258822508012303 0.409293153854496 no 1381 0.397886095294245 1952 918317 SGTC_1518 st038567 90.8 µM 0.258714911161061 0.40933142659442 no 1382 0.397927606866071 1893 77966 SGTC_2600 tangeritin 87.95 µM 0.255408003915151 0.410508129850221 no 1383 0.399203994759676 1791 68077 A bioactive flavone. SGTC_67 0335-0847 266 µM 0.254959717531168 0.410667706741903 no 1384 0.39937710598965 2022 4552207 YOR254C SEC63 SGTC_1705 st027868 56.3335 µM 0.254653054826078 0.410776878250132 no 1385 0.399495538916126 1958 292948 SGTC_403 arphamenine a 50 µM 0.253820672847813 0.411073239929276 no 1386 0.399817050859623 1883 5487158 An arginine aminopeptidase inhibitor. SGTC_2570 licareol 100 µM 0.253600230055578 0.411151734995627 no 1387 0.399902209441198 1818 443158 SGTC_425 3825-7017 13.1 µM 0.2523792246313 0.411586573818686 no 1388 0.400373978424764 1903 3397440 SGTC_705 1124-0212 310 µM 0.25203975737859 0.411707488211734 no 1389 0.400505166782205 1984 9554485 SGTC_1355 1499-0035 1.68 µM 0.251711989505095 0.411824243374828 no 1390 0.400631844523294 1831 1548538 SGTC_1043 0916-0009 19.3 µM 0.25124092014616 0.411992058053918 no 1391 0.400813924604427 2025 3101130 SGTC_817 1391-0715 46 µM 0.250133451498151 0.412386648222274 no 1392 0.401242073738532 1811 1353946 SGTC_2773 thioridazine 9.09 µM 0.249421937653463 0.412640206779017 no 1393 0.401517208735272 1965 5452 An antipsychotic. SGTC_165 k038-0023 64.381 µM 0.247981146755782 0.413153765634277 no 1394 0.402074496998003 1837 46368543 SGTC_2836 9010338 19.48 µM 0.247852552733032 0.413199609224889 no 1395 0.402124246000609 1722 2994051 SGTC_1372 2752-0194 270 µM 0.247483714242826 0.413331106198338 no 1396 0.402266946862109 1856 823334 SGTC_1153 4055-0057 267 µM 0.247061385540838 0.413481685248853 no 1397 0.402430358683862 1813 882706 SGTC_698 k064-0052 127 µM 0.246099515314161 0.413824682420305 no 1398 0.402802599132727 1914 5088751 SGTC_2004 4023728 41.89 µM 0.245258925444773 0.414124485592979 no 1399 0.403127976672942 2000 360084 YDR527W RBA50 SGTC_2678 equilin 100 µM 0.245077634298954 0.414189151112874 no 1400 0.403198160086019 1987 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_3131 9127911 49.47 µM 0.244622256288202 0.414351592114559 no 1401 0.40337446475597 1901 45595681 SGTC_701 4424-0219 185 µM 0.244173876606878 0.414511551009655 no 1402 0.403548079135106 2001 2911779 SGTC_1190 1486-1332 13 µM 0.242986829355322 0.414935097032067 no 1403 0.404007800197175 1920 4150046 SGTC_3056 9094900 49.47 µM 0.242752623578359 0.415018674841906 no 1404 0.404098519370747 1788 25236784 SGTC_1494 4358-1428 177 µM 0.241802608311661 0.415357733191467 no 1405 0.404466558868948 2026 1564571 SGTC_493 zm226600 134 µM 0.239050267055629 0.416340392714418 no 1406 0.405533302474492 1921 5240098 A potassium channel opener. YCR052W RSC6 SGTC_1294 1000-1494 117 µM 0.23810035088107 0.416679659965494 no 1407 0.405901631299609 1836 712797 YDL207W GLE1 SGTC_504 lovastatin 124 µM 0.236075379210765 0.417403095485322 no 1408 0.4066870892839 1827 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_673 1082-0474 110 µM 0.236066031664312 0.417406435613099 no 1409 0.40669071593868 1834 3098046 SGTC_1816 st051957 91.6 µM 0.235260662160768 0.417694237979728 no 1410 0.407003212672533 1899 674121 SGTC_2361 9034121 116 µM 0.234570231081031 0.417941001698123 no 1411 0.407271158539252 1877 6496917 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.233815839398539 0.418210662209624 no 1412 0.407563976160296 2026 1273210 SGTC_3012 9080433 71.4286 µM 0.233457810450233 0.418338654640219 no 1413 0.407702963413184 2024 17688859 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 0.232251777401628 0.418769865174056 no 1414 0.408171232223644 1920 2724278 An inhibitor of dopamine biosynthesis. SGTC_302 1094-0063 18.9 µM 0.232182611084225 0.41879459817792 no 1415 0.408198091548506 1882 5440289 SGTC_890 0929-0006 47.2 µM 0.231712691512594 0.418962643991148 no 1416 0.408380586618238 1836 1378169 SGTC_377 3970-0964 33.1 µM 0.231631221921969 0.418991779467891 no 1417 0.408412227668872 1931 16481235 SGTC_1497 4476-2978 41.3 µM 0.230576837548273 0.419368892598552 no 1418 0.408821781860332 1951 1528379 SGTC_1097 itavastatin 7.23 µM 0.227852869747362 0.420343494208541 no 1419 0.409880311716182 1917 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_2463 5473429 200 µM 0.226211130200718 0.42093112444457 no 1420 0.410518607159604 1897 5399405 SGTC_262 fenpropimorph 62.5 µM 0.226013846407175 0.42100175040627 no 1421 0.41059532553887 1879 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.225615802350709 0.42114425461408 no 1422 0.410750124614053 1877 688667 SGTC_3301 9125354 19.7965 µM 0.224771603143655 0.421446521506202 no 1423 0.411078479118439 1864 41905162 SGTC_3330 9141424 71.43 µM 0.223777639613489 0.42180247108963 no 1424 0.411465164885125 2001 27261020 SGTC_1439 4092-1168 46 µM 0.222892960535268 0.422119338429653 no 1425 0.411809407630421 1964 2886240 SGTC_461 N-acetylfarnesylcysteine 136 µM 0.220727598345695 0.422895123022919 no 1426 0.412652270521347 2024 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_925 2064-1272 59.6 µM 0.220390095523881 0.423016067222279 no 1427 0.412783679210454 1847 6815817 SGTC_1067 clotrimazole 1.36 µM 0.22005099333334 0.423137591863183 no 1428 0.412915720467499 1895 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_3276 9139060 49.47 µM 0.218783627744949 0.423591844524068 no 1429 0.413409300545019 1934 4870619 SGTC_3066 9117245 49.47 µM 0.218189228487577 0.423804925765698 no 1430 0.413640838667791 1968 17176980 SGTC_748 act1.228 77.9 µM 0.217668896136688 0.423991473669788 no 1431 0.413843549939894 1858 4421505 YNR035C ARC35 SGTC_1674 st016616 23.6 µM 0.215683445172574 0.424703447397555 no 1432 0.414617253174358 1814 625830 SGTC_1017 4239-0030 168 µM 0.21545633081075 0.424784905284602 no 1433 0.414705777728692 1843 1149593 SGTC_1290 0986-0249 10.2 µM 0.21505108478419 0.424930260674767 no 1434 0.414863745137214 2034 53329 SGTC_42 0133-0086 60.653 µM 0.214983947580207 0.424954342722353 no 1435 0.41488991696473 1901 162923 Model of phenazepam hydroxylation. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.213461171879941 0.425500635881475 no 1436 0.415483635754382 2003 91467 include heat shock SGTC_2189 6047310 154.431 µM 0.213337920193327 0.425544858483443 no 1437 0.415531699121107 1922 711535 SGTC_2447 5741742 33.78 µM 0.213200256768416 0.425594253112338 no 1438 0.415585383999632 1963 1776504 SGTC_626 0214-0009 33 µM 0.21272677708578 0.425764149944695 no 1439 0.415770039832746 1987 3437874 SGTC_1175 0741-0056 27.6 µM 0.212460420562738 0.425859731656646 no 1440 0.415873926354703 2010 765927 SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.211053456805357 0.426364691027452 no 1441 0.416422779101886 2005 5282309 SGTC_305 1682-2595 20.8 µM 0.210681409887384 0.426498238905457 no 1442 0.416567940889052 1960 226033 SGTC_2246 7293507 91.5585 µM 0.210636344566451 0.426514415873213 no 1443 0.416585524827531 2066 887656 SGTC_1173 0443-0020 122 µM 0.209890705243419 0.426782093786605 no 1444 0.416876488397958 1898 5331295 SGTC_1978 st071761 42 µM 0.209776642323884 0.426823044341538 no 1445 0.416921002079969 1871 5147680 SGTC_3205 9113483 49.47 µM 0.209655373140605 0.426866582934455 no 1446 0.416968329214237 2025 17018033 SGTC_394 menadione 8.33 µM 0.20845042022696 0.427299238730078 no 1447 0.417438645596263 2042 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_648 0375-0473 33.3 µM 0.208134097133758 0.427412833632555 no 1448 0.417562132211109 1946 1713139 SGTC_1481 3346-2004 36 µM 0.207539076276093 0.427626528092123 no 1449 0.417794439238139 2040 2770522 SGTC_1934 st074720 32.6 µM 0.207257765818946 0.427727564696346 no 1450 0.417904277979249 1844 17250992 SGTC_1415 3966-0071 78.1 µM 0.206973675796717 0.427829604430388 no 1451 0.418015208511552 1989 2893185 SGTC_2457 5731572 11.68 µM 0.204255313899385 0.42880623144055 no 1452 0.419076994056053 2064 2865357 SGTC_1904 st060225 78 µM 0.203539118511382 0.429063612079726 no 1453 0.419356836690943 1932 66595 SGTC_84 0443-0269 128.823 µM 0.200781751475469 0.43005481353379 no 1454 0.4204346162858 2041 6150058 SGTC_2012 4023501 200 µM 0.200297412175771 0.430228966574659 no 1455 0.420623993163038 1910 3477460 SGTC_2336 9001819 198.65 µM 0.199664374693938 0.430456607221653 no 1456 0.420871538787255 2008 2989602 SGTC_1985 st071382 65.5 µM 0.199021711252612 0.430687733012133 no 1457 0.42112288059427 1962 6123237 SGTC_2264 7948757 110.76 µM 0.198107505061796 0.431016556616728 no 1458 0.421480476509054 1864 2971411 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.196729684607658 0.43151222425693 no 1459 0.422019539531342 1923 75037 A free radical scavenger. SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.194931307862212 0.432159348184544 no 1460 0.422723362088223 1919 279621 SGTC_1655 st012546 55.1 µM 0.19486576267554 0.432182937269199 no 1461 0.422749018885171 1994 720985 YLR208W SEC13 SGTC_3244 9134489 49.47 µM 0.193620514236599 0.43263113608395 no 1462 0.423236517059053 1925 16584271 SGTC_2859 9028643 45.46 µM 0.193508261614207 0.432671543127046 no 1463 0.423280468252067 2034 17151580 SGTC_288 1315-0019 35.1 µM 0.192811107748967 0.432922510040175 no 1464 0.423553451998183 1972 6811474 SGTC_1322 1348-1070 12 µM 0.192687703097147 0.432966937035601 no 1465 0.423601777243785 2053 6758089 SGTC_1874 staurosporine 7.6 µM 0.192521427507626 0.43302679936724 no 1466 0.423666892560154 2034 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2705 st078069 42.8 µM 0.192429135815108 0.433060026771327 no 1467 0.423703035883253 1954 1530061 SGTC_77 0828-0286 12.516 µM 0.192199746269929 0.433142615009192 no 1468 0.42379287232217 2086 745345 SGTC_3294 9122953 26.2835 µM 0.191561361502035 0.433372471153643 no 1469 0.424042905485653 2013 16459826 SGTC_396 dithiazanine 1.25 µM 0.190979251942047 0.433582084554544 no 1470 0.424270924259157 1912 10578 An antihelmenthic. SGTC_518 1021-0119 62.6 µM 0.19027479882025 0.433835777958188 no 1471 0.424546900258627 1884 1097762 SGTC_2658 polymyxin b sulfate 77.05 µM 0.19020602098564 0.433860548255164 no 1472 0.424573846593249 1976 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_2238 6671620 73.2395 µM 0.190021528257178 0.433926994486172 no 1473 0.424646130382745 2077 729941 SGTC_1902 st060212 70.5 µM 0.189122491463036 0.434250814996261 no 1474 0.424998406968611 2086 688944 SGTC_1028 k015-0029 4.8 µM 0.189081810800785 0.43426546864829 no 1475 0.42501434860784 1963 4588309 SGTC_118 0083-0097 135.343 µM 0.189022224274504 0.434286932577486 no 1476 0.42503769915959 1942 5207356 SGTC_2405 ticlatone 3.52 µM 0.188656470824669 0.434418686505548 no 1477 0.425181035053437 1973 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_514 4466-0038 2.65 nM 0.184902827063135 0.435771265284434 no 1478 0.426652626776123 1983 5722064 SGTC_160 3453-0671 289.699 µM 0.184844947105564 0.435792127531061 no 1479 0.426675326288846 1991 5322268 SGTC_2485 5633444 17.78 µM 0.18081109135646 0.437246527057634 no 1480 0.428257928480869 1922 5724239 SGTC_3302 9125395 16.351 µM 0.180341075441052 0.437416046025163 no 1481 0.428442405362652 1984 17599668 SGTC_2661 dactinomycin 12.96 µM 0.180294436949556 0.437432867591001 no 1482 0.4284607113909 2056 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_2926 9010726 65.15 µM 0.180252955793477 0.437447829104712 no 1483 0.428476993247856 1921 2994293 SGTC_88 0180-0332 8.668 µM 0.178480351952499 0.43808725902201 no 1484 0.429172875162441 2049 3101745 SGTC_785 1270-0111 65.3 µM 0.177593520082614 0.4384072259336 no 1485 0.429521106936308 2144 6741994 SGTC_2998 9066762 71.4286 µM 0.177068828714742 0.438596552351677 no 1486 0.429727163044586 2058 4945196 SGTC_2937 9044753 11.33 µM 0.174250559630038 0.439613718679788 no 1487 0.430834276213452 2039 6465530 YGL099W LSG1 SGTC_2301 7769476 200 µM 0.17398054211033 0.439711194121528 no 1488 0.430940377078214 2013 977820 SGTC_948 3448-0295 75.3 µM 0.173409300073483 0.439917422667281 no 1489 0.431164857723973 2020 678569 SGTC_1663 st014140 55.4 µM 0.172071183760088 0.440400570208122 no 1490 0.431690783433712 2118 4207120 SGTC_357 1325-0123 420 µM 0.171463050379926 0.440620175523048 no 1491 0.431929840839282 2110 1098503 SGTC_112 phenothiazine 287.218 µM 0.169487514948141 0.441333694188734 no 1492 0.432706595961909 2120 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_2940 9060638 45.86 µM 0.169191078923449 0.44144077665807 no 1493 0.43282317331076 1984 4027022 SGTC_1060 3448-7350 82 µM 0.167929965282084 0.441896380249136 no 1494 0.433319187993976 2098 570178 SGTC_484 loperamide 105 µM 0.167442457487959 0.442072523238569 no 1495 0.433510960231063 2054 3955 An opioid-receptor agonist. SGTC_1805 st050013 60.3 µM 0.167379302143745 0.442095342935353 no 1496 0.433535804963055 2071 4037144 SGTC_2480 5767542 37.17 µM 0.167102419364903 0.442195390275858 no 1497 0.433644731202028 2050 2867358 SGTC_2024 5144227 134 µM 0.167040717940976 0.442217685640545 no 1498 0.433669005352583 2064 3475211 SGTC_373 0844-0104 25.9 µM 0.166494932654993 0.442414909180797 no 1499 0.433883735336534 2130 5375804 SGTC_3291 9121177 71.43 µM 0.165502319703101 0.442773633745006 no 1500 0.434274312076216 1973 17015612 SGTC_1206 3978-0017 132 µM 0.162584088563965 0.443828536207093 no 1501 0.435422957888012 2027 3873677 SGTC_3158 9100007 49.47 µM 0.162248794047365 0.443949766439195 no 1502 0.435554968354585 1974 19297233 SGTC_784 4579-0127 173 µM 0.161257101382604 0.44430835688582 no 1503 0.435945454568263 2112 1948547 SGTC_976 1348-1067 47.6 µM 0.157882445597459 0.445528953108387 no 1504 0.437274715473732 2082 5310671 YGL099W LSG1 SGTC_1068 loratadine 26.9 µM 0.15772868156913 0.445584581183817 no 1505 0.437335299381631 1995 3957 A H1 histamine antagonist. SGTC_1417 3966-0327 90.4 µM 0.156149715924655 0.446155874236789 no 1506 0.437957505654187 2037 651118 SGTC_1378 2093-0007 380 nM 0.155990344932216 0.446213543242845 no 1507 0.438020315843384 2027 3618014 SGTC_389 tpck 16.7 µM 0.15377535992974 0.44701516133127 no 1508 0.438893431326235 2023 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_927 2425-1185 123 µM 0.152687314531377 0.447409011844546 no 1509 0.439322432497976 1974 730375 SGTC_2526 patulin 37.61 µM 0.152223969459377 0.447576749193941 no 1510 0.439505144685508 2045 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_1905 st060207 84.5 µM 0.151656606032793 0.447782155398387 no 1511 0.439728892276496 1999 1948547 SGTC_2295 7971645 200 µM 0.151320461243036 0.44790385865285 no 1512 0.439861464696651 2064 2978226 YKL099C UTP11 SGTC_3099 9120367 49.47 µM 0.151145515632272 0.447967200710577 no 1513 0.439930464309048 2099 24824940 SGTC_1374 2889-5571 141 µM 0.150548153599216 0.448183495866285 no 1514 0.440166081265049 2014 2853281 SGTC_310 1273-0058 1.06 µM 0.149408734251374 0.448596103895628 no 1515 0.440615560076485 2112 2734232 SGTC_919 tnp00227 403.569 nM 0.149153808086618 0.448688425721093 no 1516 0.44071613399537 2027 1269246 A methoxyflavone. YNL221C POP1 SGTC_3118 9124250 49.47 µM 0.147752997453368 0.449195780474349 no 1517 0.441268852341658 2042 1504786 SGTC_2670 beta-carotene 100 µM 0.147028591935015 0.449458183043186 no 1518 0.44155472623066 2132 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2404 5161160 200 µM 0.145088217137514 0.450161156694668 no 1519 0.442320610606128 2047 2831543 SGTC_404 fumagillin 50 µM 0.143723159705439 0.450655793872766 no 1520 0.442859541133481 2042 12015870 A methionine aminopeptidase binder. SGTC_2477 5967686 25.23 µM 0.143566434116198 0.45071258929913 no 1521 0.442921423853979 2049 776118 SGTC_910 3454-3003 490 µM 0.142136082594462 0.451230977594262 no 1522 0.443486258854897 2174 820824 SGTC_2138 5575593 77.673 µM 0.141741814605333 0.451373882942934 no 1523 0.44364197254193 2053 762213 SGTC_980 1473-0395 201 µM 0.141201890515713 0.451569592643368 no 1524 0.443855226312412 2032 768876 SGTC_1699 st031318 29.054 µM 0.139971982789065 0.45201544895136 no 1525 0.444341063463753 2126 5340658 SGTC_1723 st034307 2.5525 µM 0.139932272120311 0.452029845556903 no 1526 0.444356751337697 2062 867466 SGTC_1405 3909-7894 12 µM 0.139639849714212 0.452135861578629 no 1527 0.444472276775343 2153 7104060 SGTC_2534 helenine 20.12 µM 0.13872686690261 0.452466880050129 no 1528 0.444832993330174 2070 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_1457 k015-0032 57.3 µM 0.137760674691517 0.452817226534894 no 1529 0.445214782501706 2050 4302660 SGTC_287 k060-0039 29.6 µM 0.137679260615012 0.452846749398125 no 1530 0.445246955458864 2171 5861974 SGTC_1760 st045453 10.4495 µM 0.137168134341338 0.45303210303748 no 1531 0.445448948953152 2169 3323419 YIL048W NEO1 SGTC_2924 9010168 62.78 µM 0.136551101314914 0.453255876085098 no 1532 0.445692814911579 2051 2993929 SGTC_2702 st077768 96.8 µM 0.135758024431632 0.453543514945714 no 1533 0.446006287706564 2045 6484119 SGTC_190 3970-0790 3.722 µM 0.133551427723203 0.454343947177602 no 1534 0.446878647526728 2164 2832352 SGTC_1753 st043925 64 µM 0.133298000644675 0.454435888552339 no 1535 0.446978854372758 2162 670181 SGTC_2996 9066192 71.4286 µM 0.132895166619549 0.454582038628832 no 1536 0.447138144738862 2031 6472854 SGTC_2419 paclitaxel 166.5 µM 0.132178214684099 0.454842167356234 no 1537 0.44742166604132 2017 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_3304 9125678 46.087 µM 0.13018416063375 0.455565763292307 no 1538 0.448210362956102 2079 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_508 roscovitine 141 µM 0.129104331695473 0.455957669839889 no 1539 0.448637547249609 2126 160355 A CDKinase inhibitor. SGTC_2061 5245884 80.95 µM 0.127842742696984 0.456415597534189 no 1540 0.449136711895002 2122 573863 SGTC_780 0109-0199 192 µM 0.124027558378801 0.457800771187576 no 1541 0.45064672754725 2198 610414 SGTC_497 capsazepine 133 µM 0.12388462316686 0.457852676544834 no 1542 0.450703314043466 2072 2733484 A calcium channel blocker. SGTC_2805 7950783 58.44 µM 0.123764256122872 0.457896387076569 no 1543 0.450750966824618 2105 1178958 YDL195W SEC31 SGTC_1189 1431-2119 7.28 µM 0.123533321257926 0.457980251039375 no 1544 0.450842394904772 2184 3107275 SGTC_2262 9014885 67.46 µM 0.123477621924491 0.458000478524414 no 1545 0.450864446894738 2157 6457424 SGTC_1228 0124-0032 52.5 µM 0.122372328280174 0.458401893739513 no 1546 0.451302076307222 2145 X1228 SGTC_2391 6285546 200 µM 0.119749362469874 0.459354658876102 no 1547 0.452340848037293 2095 846083 SGTC_726 3448-4391 34.2 µM 0.119524351260253 0.459436402816816 no 1548 0.452429974402585 2145 1356692 SGTC_964 1287-0107 19.4 µM 0.11851046004862 0.459804758858786 no 1549 0.452831603791465 2166 51516812 YPR165W RHO1 SGTC_2360 9040895 200 µM 0.11735936880616 0.460223002746538 no 1550 0.453287640254107 2087 4914414 SGTC_1364 1653-0028 37.6 µM 0.116990490120987 0.460357042512264 no 1551 0.453433794757221 2114 5718652 SGTC_1325 1431-0015 227 µM 0.11519263812882 0.461010393745127 no 1552 0.454146216877934 2004 1103340 SGTC_2958 9077254 16.72 µM 0.113904365124612 0.461478625462255 no 1553 0.454656802611012 2103 16457351 SGTC_2656 pseudo-anisatin 100 µM 0.112464493616926 0.462002019870439 no 1554 0.455227560542435 2143 6708809 A neurotoxin. SGTC_809 3998-0021 90 µM 0.111623773099617 0.462307652917891 no 1555 0.455560860806197 2224 715485 SGTC_3344 9148862 3.898 µM 0.111402860489668 0.46238796653378 no 1556 0.455648445919855 2182 4905352 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.109106182606308 0.46322302271354 no 1557 0.456559135578534 2186 688751 SGTC_636 0kpi-0074 126 µM 0.108786654611031 0.463339213807608 no 1558 0.456685854535074 2113 616434 SGTC_788 1182-0090 188 µM 0.108188490122057 0.463556734874196 no 1559 0.456923087458242 2199 5715185 SGTC_1346 1488-2224 62.4 µM 0.107274422618989 0.46388915433018 no 1560 0.457285637612874 2220 3722427 SGTC_1240 0356-0016 42.1 µM 0.10545989092813 0.464549120591845 no 1561 0.458005447431973 2145 4305613 SGTC_3328 9140624 29.0385 µM 0.104581931563346 0.464868479743469 no 1562 0.45835377629775 2211 4904392 SGTC_2981 9013952 38.96 µM 0.104432541651198 0.464922822826514 no 1563 0.458413049679604 1987 2996344 SGTC_2930 9013230 14.89 µM 0.104224985959334 0.464998325772018 no 1564 0.458495403011643 2187 2995857 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.102347526207221 0.465681349954171 no 1565 0.459240416439806 2124 442882 SGTC_9 0092-0002 10.449 µM 0.101750724274061 0.465898489146114 no 1566 0.459477269447548 2231 759368 SGTC_1021 4476-0760 85.3 µM 0.10121550789652 0.466093229812644 no 1567 0.459689693208647 2049 746768 SGTC_1950 st077106 7.18 µM 0.100466309554796 0.466365842317688 no 1568 0.459987064279682 2073 13831864 SGTC_2446 5162541 200 µM 0.0983093110529387 0.4671508019478 no 1569 0.460843342423965 2182 1549321 SGTC_821 1114-0266 29.2 µM 0.0981940365934851 0.46719275543698 no 1570 0.460889108845109 2153 3123235 SGTC_2124 5246320 200 µM 0.0974648870044353 0.467458133740929 no 1571 0.461178608774066 2161 579342 SGTC_2832 7992762 51.95 µM 0.0969130364349003 0.467658992641244 no 1572 0.461397727981816 2015 2985177 SGTC_723 4182-0001 115 µM 0.0954439241499459 0.468193750363404 no 1573 0.46198111443531 2102 744821 YLR208W SEC13 SGTC_642 0335-0876 158 µM 0.0949841668927569 0.468361114108411 no 1574 0.462163701522498 2164 6812350 SGTC_3288 9119690 36.221 µM 0.0942805537374626 0.46861725863739 no 1575 0.462443148484512 2142 17595618 YKL019W RAM2 SGTC_2841 9004761 38.96 µM 0.0941662172215604 0.468658883126837 no 1576 0.462488560123477 2072 2991039 SGTC_2148 5546263 113.568 µM 0.0935391697366095 0.468887167383422 no 1577 0.462737616568561 2143 792097 SGTC_773 4358-1457 44.6 µM 0.0903754939193943 0.470039096476128 no 1578 0.463994415003534 2259 1186886 SGTC_1012 4112-3522 18 µM 0.0875111984182528 0.471082234488588 no 1579 0.465132592265492 2242 3112398 SGTC_3232 9132874 49.47 µM 0.0860443593874827 0.471616514877078 no 1580 0.465715577134114 2151 3784940 SGTC_1526 st051518 75 µM 0.0858174716786132 0.471699160878278 no 1581 0.465805758662773 2080 673993 SGTC_1265 0819-1001 68.8 µM 0.0854170849018524 0.471845008532176 no 1582 0.465964905506715 2263 3106768 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.0840931877991741 0.472327287214061 no 1583 0.466491170404638 2257 3256 An antibiotic and ribosome inhibitor. SGTC_1743 st037606 46.3785 µM 0.0830483225967458 0.472707946848104 no 1584 0.466906558207762 2206 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_2713 st079149 53.4 µM 0.0828131669030058 0.472793620946095 no 1585 0.467000049708561 2175 3103253 SGTC_1263 0774-1208 64.8 µM 0.0823861791238172 0.472949188299122 no 1586 0.467169813073924 2259 906585 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM 0.0821657637591941 0.473029495339782 no 1587 0.467257448961042 2188 4174840 SGTC_192 3455-0609 60.9 µM 0.0776366806551338 0.47467987810361 no 1588 0.46905853174129 2214 3769639 SGTC_2665 lovastatin 100 µM 0.0768823069976616 0.474954812332011 no 1589 0.469358586426095 2212 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2783 7738165 71.43 µM 0.0755480758222454 0.475441106865558 no 1590 0.469889323911765 2168 17201110 SGTC_1280 0880-0253 10.1 µM 0.0726244648309094 0.476506818268881 no 1591 0.471052479001735 2213 6836607 SGTC_368 fentichlor 4.58 µM 0.0725252979289387 0.476542969466836 no 1592 0.471091936820376 2186 7329 A pesticide. SGTC_878 0828-0289 13.7 µM 0.0711444992027183 0.47704635823025 no 1593 0.471641376315751 2219 745350 YLR208W SEC13 SGTC_1136 pergolide 1.05886 µM 0.0695583000088406 0.477624673657962 no 1594 0.472272614140076 2151 47811 A dopamine receptor agonist. SGTC_2849 9019321 12.99 µM 0.0690613482974205 0.477805867993764 no 1595 0.472470393564558 2231 16489627 SGTC_1769 st044406 64.4 µM 0.0685459275849735 0.477993801187087 no 1596 0.472675530548436 2149 670903 SGTC_2850 9015429 58.44 µM 0.0679465076342974 0.478212368414993 no 1597 0.472914108266112 2233 6457570 SGTC_944 3370-0224 231 µM 0.0670670303895387 0.478533065117841 no 1598 0.473264170357844 2246 4580514 SGTC_2311 7694451 200 µM 0.0661476554263396 0.478868325167864 no 1599 0.473630135179832 2244 2163142 SGTC_2383 9036125 200 µM 0.0660760719757088 0.478894429479867 no 1600 0.47365863050339 2178 79580 SGTC_3295 9122362 53.5725 µM 0.0660033246624837 0.47892095830999 no 1601 0.473687589265433 2197 4730473 SGTC_1627 st003713 25.6 µM 0.065095441007054 0.479252044901183 no 1602 0.474049005142536 2217 16195070 YER133W GLC7 SGTC_2216 7189485 200 µM 0.0629862740960323 0.480021269789869 no 1603 0.474888717151083 2278 731273 SGTC_2653 dihydrofissinolide 100 µM 0.0629499972589389 0.480034500812974 no 1604 0.474903160852258 2248 6857746 SGTC_2478 5763493 32.33 µM 0.0615324600273043 0.480551527349549 no 1605 0.475467582005861 2252 1365576 YLR208W SEC13 SGTC_853 0419-0306 21 µM 0.0615200161489431 0.480556066223276 no 1606 0.475472537007665 2168 762713 SGTC_99 0109-0120 622.8 µM 0.0614823149589202 0.48056981765409 no 1607 0.475487549188536 2288 759414 SGTC_1687 st020778 55.3625 µM 0.0613326905245789 0.480624393083798 no 1608 0.475547128262744 2222 4259299 SGTC_219 mitoxanthrone 164.414 µM 0.058852565130045 0.481529069579481 no 1609 0.476534770031395 2275 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_2791 5663188 71.43 µM 0.0585406944580356 0.481642837619187 no 1610 0.476658974283476 2286 54690634 SGTC_2112 5488546 200 µM 0.0579697707736309 0.48185111008655 no 1611 0.476886353723823 2305 600757 SGTC_1047 2043-3044 82 µM 0.0579624673576447 0.481853774398608 no 1612 0.47688926247434 2275 669592 SGTC_274 sirtinol 40.1 µM 0.0569205258217799 0.482233886614935 no 1613 0.47730425178899 2156 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_3175 9106517 49.47 µM 0.0563930031762474 0.482426339103165 no 1614 0.477514365371817 2247 41468073 SGTC_1104 tacrolimus 29.8 µM 0.0563234654195564 0.482451708395031 no 1615 0.477542062900946 2305 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_1436 4092-1007 8.32 µM 0.0542367152336046 0.483213045024784 no 1616 0.478373284597024 2300 2881121 SGTC_2792 7535235 81.82 µM 0.0538788119089658 0.483343629848291 no 1617 0.47851585889421 2245 1281891 SGTC_2586 curcumin 80 µM 0.0529475730965366 0.48368341054218 no 1618 0.478886839840033 2287 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_40 0327-0103 19.753 µM 0.0525975733131815 0.483811117885436 no 1619 0.479026275255844 2288 409036 SGTC_343 4130-2827 29.8 µM 0.0525671259614812 0.483822227543579 no 1620 0.479038405211089 2241 1118244 SGTC_194 1486-1323 56.904 µM 0.0524405262639455 0.483868421494116 no 1621 0.479088841617353 2268 5178754 SGTC_2335 9018011 154.17 µM 0.0524046354876166 0.483881517431699 no 1622 0.479103140304698 2276 6458208 SGTC_10 0279-0212 42.575 µM 0.0518345248542912 0.484089543487018 no 1623 0.479330272831019 2319 39851 YBR002C RER2 SGTC_2865 9030313 51.95 µM 0.0492191328022827 0.485043921128396 no 1624 0.480372331986548 2304 42562754 SGTC_2701 st077767 14.721 µM 0.0489569409087105 0.485139601879421 no 1625 0.480476805470816 2289 5721188 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.0489097603574164 0.485156819400442 no 1626 0.48049560526626 2201 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_117 lucigenin 22.078 µM 0.0483786693640779 0.485350631464934 no 1627 0.480707229388775 2191 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2390 9097792 176.6 µM 0.0481519176168094 0.485433381475955 no 1628 0.480797584943033 2215 4497149 SGTC_2561 acetosyringone 100 µM 0.0478095236511909 0.485558334752195 no 1629 0.480934023230712 2335 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1748 st037455 53.6035 µM 0.0456247807978948 0.486355667824998 no 1630 0.48180465875749 2293 580690 SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 0.0449772401015483 0.486592001735722 no 1631 0.482062725179564 2257 4213774 SGTC_918 glabranin 770.725 nM 0.0446448285820566 0.486713324306868 no 1632 0.482195205110019 2278 124049 Also referred to as licorice root. SGTC_1362 1611-0397 101 µM 0.0434111902896352 0.48716358461599 no 1633 0.482686878775177 2315 27816 SGTC_2287 7945887 168.79 µM 0.0433650671687078 0.487180419215472 no 1634 0.482705261926657 2303 1245853 SGTC_960 1222-0186 7.7 µM 0.0429616832613607 0.487327652341302 no 1635 0.482866038981649 2298 3126296 SGTC_3202 9113761 49.47 µM 0.0425645563172464 0.487472603393914 no 1636 0.483024324915608 2304 4798415 SGTC_2760 etidronate 98.04 µM 0.0418630010383584 0.487728674604678 no 1637 0.483303955710163 2320 3305 A chelator and antioxidant. SGTC_1434 4073-0095 163 µM 0.041517822703128 0.487854668299329 no 1638 0.483441542320725 2328 24133745 SGTC_2787 5284540 71.43 µM 0.0384468602383677 0.488975653555758 no 1639 0.484665699756186 2283 736958 SGTC_1285 0929-0069 65.5 µM 0.0381822322332857 0.489072254214282 no 1640 0.484771193594547 2307 1206237 SGTC_1277 0873-0036 22 µM 0.0377924247259546 0.489214551967129 no 1641 0.484926592126072 2323 5965735 SGTC_78 0336-0123 156.75 µM 0.037765912500249 0.489224230204686 no 1642 0.48493716142856 2240 6765896 SGTC_1149 3909-7961 23.3 µM 0.0377410874786879 0.489233292537331 no 1643 0.484947058123747 2211 735261 SGTC_2167 5876490 200 µM 0.0370961455939461 0.489468729429201 no 1644 0.485204172642682 2303 686534 SGTC_2881 9058953 51.95 µM 0.0344110866083713 0.490448952290571 no 1645 0.486274671436742 2325 17122249 SGTC_376 3970-0862 59.1 µM 0.0334435503598149 0.490802181008561 no 1646 0.486660440452962 2344 3135186 SGTC_317 4495-0002 170 µM 0.0327073533110904 0.491070957119028 no 1647 0.486953979967869 2247 15991618 SGTC_154 3389-1638 511.116 µM 0.0322634628451003 0.491233017808168 no 1648 0.487130973225878 2158 5238686 SGTC_1575 cyproterone acetate 48 µM 0.0295273143497461 0.492231993630843 no 1649 0.488222017367203 2319 9880 An androgen receptor antagonist and liver toxin. SGTC_205 1486-1330 71.903 µM 0.0283926348753834 0.492646283078132 no 1650 0.488674499176426 2340 4118834 SGTC_1042 0350-0096 82 µM 0.0283458566365627 0.49266336272732 no 1651 0.488693153485557 2350 3122515 SGTC_3319 9138450 16.7555 µM 0.0276050435640387 0.492933849830467 no 1652 0.488988579508671 2281 2029690 SGTC_1270 0831-1170 17.3 µM 0.0265771680312173 0.493309155089641 no 1653 0.489398492048914 2352 6764716 SGTC_541 4513-1321 94 µM 0.0237958573260471 0.494324715876407 no 1654 0.490507722245056 2333 747515 SGTC_724 3910-0327 137 µM 0.0221227488986259 0.494935648614352 no 1655 0.491175019959271 2342 2885483 SGTC_251 melphalan 456.522 µM 0.0211309781634827 0.49529779773511 no 1656 0.491570586703478 2305 460612 A DNA alkylator. SGTC_1640 st009078 66.4 µM 0.0211248850665322 0.495300022666545 no 1657 0.49157301695499 2361 690618 SGTC_3048 9093155 49.47 µM 0.0204377830365111 0.495550923075914 no 1658 0.491847071816742 2379 25236002 SGTC_1191 1487-1166 10.6 µM 0.0193286697701042 0.495955927692902 no 1659 0.492289456514374 2343 3955771 SGTC_991 3996-0057 64.7 µM 0.0192103633113111 0.49599912881986 no 1660 0.492336645201074 2357 715343 SGTC_2616 abietic acid 100 µM 0.0185817681058794 0.496228669228786 no 1661 0.492587373634945 2381 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_1382 3002-2117 298 µM 0.0181482465397133 0.496386976477866 no 1662 0.49276029455252 2366 1497314 SGTC_3214 9129694 49.47 µM 0.017222011275887 0.49672520779275 no 1663 0.493129751166813 2369 17158655 SGTC_1697 st025554 27.742 µM 0.0162979860738348 0.497062634410001 no 1664 0.493498332104579 2374 1269519 SGTC_3166 9102297 49.47 µM 0.0157667940570393 0.497256610957645 no 1665 0.493710219823302 2357 25237072 SGTC_1278 0874-0585 172 µM 0.0144374820646652 0.497742041459854 no 1666 0.494240478069207 2369 766306 SGTC_2146 5545642 200 µM 0.0141930056498395 0.497831318335132 no 1667 0.494338000054482 2376 825326 SGTC_1870 st057514 26.5 µM 0.0138855312482859 0.497943600705525 no 1668 0.49446065250486 2382 5393161 SGTC_170 4197-0004 226 µM 0.0136290022548837 0.498037279144284 no 1669 0.494562983082074 2354 218692 SGTC_2968 9090663 33.37 µM 0.0131889013957944 0.498197994020074 no 1670 0.494738542137521 2328 25236811 SGTC_1795 st049545 62.3 µM 0.0128153117161377 0.498334420748578 no 1671 0.494887570257901 2392 5291882 SGTC_2636 apigenin dimethyl ether 100 µM 0.0126045065318179 0.498411402249171 no 1672 0.494971662566213 2373 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_421 streptovitacin 30 mM 0.0124394544003518 0.498471675764415 no 1673 0.495037503677706 2316 91467 include heat shock SGTC_44 0929-0055 61.211 µM 0.0102887391870943 0.499257073736264 no 1674 0.495895459342889 2372 1379590 SGTC_1617 st002906 78 µM 0.00971125052614483 0.49946796160594 no 1675 0.496125832464061 2392 5150859 SGTC_3324 9138759 60.749 µM 0.00884720244714194 0.499783495781448 no 1676 0.496470522924412 2363 45595710 SGTC_1094 duloxetine 25.4 µM 0.00840372185103568 0.499945446654135 no 1677 0.496647439501992 2396 60834 A selective serotonin reuptake inhibitor. SGTC_2645 abamectin 100 µM 0.00810494792712348 0.499945446654135 no 1678 0.496766628991578 2385 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_2239 6685329 187.64 µM 0.00739931167211548 0.499687761421412 no 1679 0.497048128663884 2312 805680 SGTC_768 0384-0033 77.3 µM 0.00727636251863361 0.499642862688197 no 1680 0.497097176959024 2387 3965305 YMR134W ERG29 SGTC_478 N-arachidonylglycine 10 µM 0.00711099641779904 0.499582474085721 no 1681 0.497163146781358 2393 5283389 SGTC_929 2805-0021 398 µM 0.00697953860760161 0.499534468162591 no 1682 0.497215589558361 2323 3098024 SGTC_1469 k284-2957 126 µM 0.00687210083826145 0.499495233912192 no 1683 0.497258449999087 2369 23884841 SGTC_1729 st035615 45.989 µM 0.00684632074871987 0.499485819509621 no 1684 0.497268734524858 2307 17385451 SGTC_2753 fluvastatin 17.09 µM 0.00523531611605422 0.498897511777343 no 1685 0.49791142059086 2387 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_1521 st012942 49.4 µM 0.00503910869221374 0.498825860759339 no 1686 0.497989694994958 2387 24207259 SGTC_791 1348-1292 225 µM 0.00502222790903845 0.498819696237453 no 1687 0.497996429367877 2384 5437054 SGTC_1389 3405-0187 19 µM 0.00450251559302997 0.498629907916339 no 1688 0.498203762230858 2396 799890 SGTC_358 0075-0058 9.45 µM 0.00349712795361489 0.49826276180661 no 1689 0.498604850643087 2399 1069125 SGTC_2143 5623677 140.463 µM 0.00300762722604065 0.498084007100765 no 1690 0.498800132144811 2399 5375313 SGTC_2266 7929956 200 µM 0.00248570776175412 0.497893414222732 no 1691 0.499008347098309 2400 2967153 SGTC_410 α-linolenic acid 100 µM 0.00243915703829871 0.497876415001376 no 1692 0.499026918093774 2385 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_832 4083-0019 164 µM 0.000586353932543992 0.497199818657622 no 1693 0.499766078638433 2402 1990758 SGTC_2242 6630449 61.2675 µM 0.000354060682608299 0.497114991627445 no 1694 0.499858750226831 2401 691249 YDR170C SEC7 SGTC_1843 st055809 45.5 µM 7.1185238479984e-05 0.49701169356416 no 1695 0.499971601198654 2403 16413835 SGTC_522 1273-0010 11.6 µM -0.000345747769193216 0.496859441860407 no 1696 0.499862066599262 2415 5705015 SGTC_1070 indatraline 8.81 µM -0.000584485591294563 0.496772262015637 no 1697 0.499766823998624 2406 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_1158 4092-0494 91.8 µM -0.00121499402647795 0.496542020123194 no 1698 0.499515287631659 2415 1148199 SGTC_604 1000-0114 314 µM -0.00155559838943366 0.496417642573774 no 1699 0.499379406281425 2413 1572745 SGTC_2555 cholic acid 100 µM -0.00237603793337181 0.496118046396659 no 1700 0.499052098900445 2420 6708657 Influences liver metabolism. SGTC_365 0121-0052 13.6 µM -0.00409456028773056 0.495490508699745 no 1701 0.498366511345928 2422 3101739 SGTC_2100 5377183 190 µM -0.00429526271977673 0.495417220655334 no 1702 0.498286443364632 2418 2844202 SGTC_610 4215-0184 155 µM -0.00452319286014577 0.495333990390476 no 1703 0.498195513278761 2415 5605015 SGTC_2023 5144124 124 µM -0.00493351446778358 0.495184159136101 no 1704 0.498031820471938 2419 2830192 SGTC_439 amiodarone 34.4 µM -0.00573648231944607 0.494890952871323 no 1705 0.49771148721344 2428 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_1055 3448-0672 86 µM -0.00586168125859396 0.494845236325217 no 1706 0.497661540903024 2432 748378 SGTC_831 k061-1017 217 µM -0.00600568685787024 0.494792652587865 no 1707 0.497604091992264 2426 1240153 SGTC_1974 st069448 26.9 µM -0.00605175848226488 0.494775829523595 no 1708 0.497585712407379 2416 6323587 YNR016C ACC1 SGTC_3127 9126946 49.47 µM -0.00851583135310017 0.493876087045903 no 1709 0.496602715882022 2436 27243249 SGTC_644 1498-1197 63.3 µM -0.00861061359511318 0.493841478431319 no 1710 0.496564904624618 2427 6741615 SGTC_2125 5246583 200 µM -0.00883488755398018 0.49375958763304 no 1711 0.496475435663969 2417 835267 SGTC_568 1193-0097 7.48 µM -0.00916127020595423 0.493640413608262 no 1712 0.496345233096145 2426 3646150 SGTC_595 3909-8003 73.7 µM -0.0096001774296701 0.493480153719017 no 1713 0.49617014215283 2433 699517 SGTC_2620 irigenin 100 µM -0.0109675641799201 0.492980881378222 no 1714 0.495624662652162 2431 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.0113185300857626 0.492852735345465 no 1715 0.495484656206455 2438 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.0114154115252996 0.492817361747853 no 1716 0.495446008600924 2424 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_2437 5741531 144.16 µM -0.0145617716799129 0.491668587015669 no 1717 0.494190898898718 2434 2262990 SGTC_1857 st056007 79.3 µM -0.0157039485095517 0.491251580822853 no 1718 0.493735288465612 2444 619834 SGTC_684 1140-0066 328 µM -0.0166232980626114 0.490915935291656 no 1719 0.493368568979535 2438 6813534 SGTC_1961 st076550 68.7 µM -0.0169504745336991 0.490796487901194 no 1720 0.493238062842228 2454 1579337 SGTC_1305 1181-0477 144 µM -0.01697192963823 0.490788654982026 no 1721 0.493229504724999 2451 6252086 SGTC_995 3931-2021 34.6 µM -0.0176738874758045 0.490532383259941 no 1722 0.492949506084869 2445 730143 SGTC_3006 9075424 71.4286 µM -0.0184276736534163 0.490257194331586 no 1723 0.492648837902804 2448 7465181 SGTC_2431 5490079 200 µM -0.0190621707944933 0.490025558507235 no 1724 0.492395754637786 2451 5722345 SGTC_212 3807-4682 38.772 µM -0.0209801346775569 0.489325388347835 no 1725 0.491630751209642 2470 3125501 YBL034C STU1 SGTC_1733 st037357 54.9 µM -0.0221749967731021 0.488889209565409 no 1726 0.491154181185176 2458 1272339 YGL099W LSG1 SGTC_949 1165-0505 146 µM -0.0227798388986516 0.48866841982817 no 1727 0.49091294504009 2451 6244267 SGTC_2907 7721985 69.9 µM -0.0254680773345994 0.487687156368136 no 1728 0.489840805410382 2476 3267881 SGTC_3154 9100113 49.47 µM -0.0256757483957653 0.487611355096785 no 1729 0.489757983727733 2460 25237525 SGTC_2587 piperic acid 92.2 µM -0.0258617557301834 0.487543461604725 no 1730 0.489683802171102 2464 5370536 SGTC_1036 k216-0215 33.5 µM -0.025908787559262 0.487526294838142 no 1731 0.489665045470951 2454 622330 SGTC_253 dyclonine 31.25 µM -0.0262908486530445 0.487386842188022 no 1732 0.489512677053431 2452 3180 An oral anasthetic. SGTC_285 1486-1325 46 µM -0.0280272817610277 0.486753062195171 no 1733 0.488820195995782 2471 22310230 SGTC_532 1548-0774 215 µM -0.028036227482042 0.486749797185453 no 1734 0.48881662857132 2492 5932993 SGTC_1129 3453-1384 223 µM -0.0289136960676128 0.486429543006336 no 1735 0.488466711153417 2568 1084452 SGTC_2215 7188065 200 µM -0.0293785971716376 0.486259869216009 no 1736 0.488281321209391 2467 940217 SGTC_2362 9071156 126 µM -0.0309481141471975 0.485687065093637 no 1737 0.487655459370332 2481 653133 SGTC_2407 paclitaxel 400 µM -0.0316673924472769 0.485424570194743 no 1738 0.487368649447702 2680 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1476 4112-3294 3.34 µM -0.0320584974770647 0.48528184216602 no 1739 0.487212700299804 2532 704369 SGTC_1720 st037298 9.481 µM -0.032556448780875 0.485100124891966 no 1740 0.487014150120867 2487 597396 SGTC_2975 9084847 53.72 µM -0.0332905146618505 0.48483224802416 no 1741 0.486721458886068 2552 27211724 SGTC_904 1141-0088 396 µM -0.0336598078342141 0.484697487362134 no 1742 0.486574214749591 2476 1378119 SGTC_1563 conessine 56.1 µM -0.0342321049427484 0.484488650953131 no 1743 0.486346032747289 2485 441082 An anti-amoebic, histamine inhibitor. SGTC_2349 9023730 187.07 µM -0.0348379136913337 0.484267590479468 no 1744 0.486104494107855 2488 4126287 SGTC_579 4491-1009 110 µM -0.0349840385086197 0.484214270047155 no 1745 0.486046234253758 2460 1271041 SGTC_2514 salinomycin 42.74 µM -0.035334242429326 0.484086483017924 no 1746 0.485906609430086 2501 23682228 A polyether potassium ionophore. SGTC_2142 5622915 118.518 µM -0.035604217908101 0.483987971916599 no 1747 0.485798972525738 2494 5322196 SGTC_2826 7992541 19.48 µM -0.0356584902062069 0.48396816866602 no 1748 0.48577733475132 2459 2985066 SGTC_2413 inermin 26.06 µM -0.0359472191794389 0.483862815912211 no 1749 0.485662222358457 2490 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_2947 9072639 7.68 µM -0.0365335288171426 0.483648884033275 no 1750 0.485428472207926 2494 16488146 SGTC_113 0099-0221 2.5 µM -0.0374196202605708 0.483325577121193 no 1751 0.485075214459799 2462 89219 SGTC_2676 harmalol 100 µM -0.0384682259617493 0.482942988046247 no 1752 0.484657182366643 2463 5459187 A monoamine oxidase inhibitor SGTC_3270 9137563 49.47 µM -0.0393859621782123 0.48260816023826 no 1753 0.484291335892496 2599 17015724 SGTC_707 0865-0008 204 µM -0.0394167883814688 0.482596913786739 no 1754 0.484279047559 2486 723043 SGTC_1380 2291-0730 164 µM -0.0417030546770602 0.481762844984231 no 1755 0.483367709400638 2519 2999191 SGTC_2751 anetholtrithion 17.25 µM -0.0463294606649723 0.480075301433024 no 1756 0.481523829149328 2527 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2193 5925765 200 µM -0.0463574490174862 0.480065093362643 no 1757 0.481512675396131 2505 877370 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.0463698917971668 0.480060555165793 no 1758 0.481507716777594 2472 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1268 0828-0275 2.46 µM -0.0464858449665897 0.480018264232852 no 1759 0.48146150798525 2555 745337 SGTC_1740 st038286 13.222 µM -0.0465218583510366 0.480005129323916 no 1760 0.481447156250517 2531 716786 SGTC_1967 st070177 51.4 µM -0.0465974949212998 0.479977542999228 no 1761 0.481417014313312 2535 5729214 SGTC_800 3448-7362 155 µM -0.0466532818479591 0.479957196338617 no 1762 0.481394782727636 2484 15991913 SGTC_2035 5154463 94.595 µM -0.0468171910345535 0.479897415527509 no 1763 0.481329463796224 2495 2769623 SGTC_3141 9094609 49.47 µM -0.0478832085831754 0.479508629659115 no 1764 0.480904660824472 2494 25236309 YDL196W YDL196W SGTC_1873 rapamycin 2 nM -0.0480338088343066 0.479453706001202 no 1765 0.480844649070685 2518 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2888 9058547 12.99 µM -0.0480709878623915 0.479440146932287 no 1766 0.480829833898677 2506 16476514 SGTC_1527 coumarin 137 µM -0.0494739549424678 0.47892850699404 no 1767 0.480270796360167 2672 323 A hepatotoxic, DNA x-linker. SGTC_1051 3253-3903 78 µM -0.0498232397244691 0.478801133715267 no 1768 0.480131623528527 2478 5509239 SGTC_2505 galangin 7.89 µM -0.0505596101672339 0.478532609464031 no 1769 0.479838224027289 2494 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_704 1310-0270 142 µM -0.0514812761047878 0.478196529252374 no 1770 0.479471010784296 2549 5718033 SGTC_2592 piperlongumine 83.33 µM -0.0518520341935976 0.478061338795602 no 1771 0.479323296996135 2551 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_114 0364-0001 490.298 µM -0.0526379076645033 0.477774792135678 no 1772 0.479010206437434 2528 4003655 SGTC_789 1309-1135 70.6 µM -0.053204574105 0.477568180275272 no 1773 0.478784455585329 2508 3092424 SGTC_3300 9124615 50.48 µM -0.0545945671690262 0.4770614015086 no 1774 0.478230733538194 2588 24824903 SGTC_942 3253-1115 227 µM -0.0550819178645336 0.476883726640419 no 1775 0.478036600862933 2555 46497897 SGTC_5 0352-0601 109.883 µM -0.0551541761709192 0.476857383608684 no 1776 0.47800781772421 2457 762456 SGTC_2027 5150920 200 µM -0.0555114837018693 0.476727122376092 no 1777 0.477865490693529 2556 786715 SGTC_2978 9011784 42.97 µM -0.0565712947128236 0.476340768797902 no 1778 0.477443350706795 2647 2994934 SGTC_2789 5281112 71.43 µM -0.0587519451443817 0.475545884126991 no 1779 0.476574842259016 2539 765948 SGTC_806 3966-4455 5.86 µM -0.0592651516028317 0.475358825555906 no 1780 0.4763704586491 2528 714982 SGTC_1471 k673-0312 37 µM -0.0594293122509096 0.475298991802105 no 1781 0.476305083256447 2525 24099884 SGTC_2271 7849410 118.62 µM -0.0603486163536152 0.474963931482833 no 1782 0.475938991112401 2493 972430 SGTC_2902 5787006 60.46 µM -0.0611754976340865 0.47466257178396 no 1783 0.475609721615524 2522 591003 SGTC_3044 9093193 49.47 µM -0.0615412315128846 0.474529283439936 no 1784 0.47546408930871 2582 25236277 SGTC_1253 0550-0034 176 µM -0.0629278231778319 0.474023978895621 no 1785 0.474911989526869 2569 5969915 SGTC_782 0083-0095 30.5 µM -0.0632539094645176 0.473905151909462 no 1786 0.474782158571222 2499 3591729 An indicator and reagent. SGTC_2601 securinine 100 µM -0.0640498323299512 0.473615124597177 no 1787 0.474465273886026 2549 442872 A GABA receptor antagonist. SGTC_1529 apigenin 74 µM -0.0644258368724279 0.473478116693779 no 1788 0.474315578954156 2562 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_174 3553-0389 74.3 µM -0.066861369370231 0.472590738143575 no 1789 0.473346033482337 2595 738071 SGTC_609 0986-0026 86.3 µM -0.0668619352792031 0.47259053197207 no 1790 0.473345808221396 2526 2848610 SGTC_659 k018-0002 107 µM -0.0669822321101696 0.472546705693358 no 1791 0.473297924075635 2541 6797879 YHR007C ERG11 SGTC_2225 6654152 15.4 µM -0.0680535599899523 0.4721564165817 no 1792 0.472871499181515 2523 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_2798 7813637 45.45 µM -0.0684634618133894 0.472007094728093 no 1793 0.472708352525954 2591 956368 SGTC_1486 3970-0793 4.53 µM -0.0694765269441045 0.471638065321702 no 1794 0.472305158140684 2609 2844330 SGTC_908 3448-7491 47.7 µM -0.0700780262041702 0.471418968584557 no 1795 0.472065778122623 2524 1203031 SGTC_2430 5571206 200 µM -0.0709360849904897 0.471106434757405 no 1796 0.471724312015677 2541 1731771 SGTC_1247 0448-0043 5.84 µM -0.0731494298573031 0.470300342837061 no 1797 0.470843603822334 2597 3089013 YGL099W LSG1 SGTC_1024 4507-0395 26 µM -0.0739882688577925 0.469994872431498 no 1798 0.4705098598853 2688 4201836 SGTC_933 2914-0560 114 µM -0.0745225712580332 0.469800310831005 no 1799 0.470297290916976 2541 463887 SGTC_49 0717-0965 32.132 µM -0.0752112587093551 0.469549541891378 no 1800 0.470023313286836 2809 5889349 YGL099W LSG1 SGTC_2346 9031566 143.75 µM -0.075565419070946 0.469420587626488 no 1801 0.469882424677961 2626 4771086 SGTC_649 1123-0311 367 µM -0.0762861714031694 0.469158162511168 no 1802 0.469595713702434 2591 693629 YIL048W NEO1 SGTC_3000 9075062 71.4286 µM -0.0765124835539023 0.469075765269636 no 1803 0.469505691324757 2576 17057871 SGTC_2985 9022375 71.43 µM -0.0775063028649342 0.468713944613376 no 1804 0.469110388698869 2728 4939335 SGTC_1621 st003705 32.4 µM -0.0776669335626897 0.468655466074142 no 1805 0.469046498909906 2534 24207032 SGTC_899 1083-0020 478 µM -0.0782994951963398 0.468425184921701 no 1806 0.468794909503327 2703 767123 SGTC_209 4077-0173 175.592 µM -0.0789268929109602 0.468196794105167 no 1807 0.468545386256006 2620 15993494 SGTC_2439 5492030 7.2 µM -0.0795111132660517 0.467984130499535 no 1808 0.468313046245928 2597 5722370 SGTC_2261 9010538 184.68 µM -0.0796378115712632 0.467938011915884 no 1809 0.468262660710952 2658 6457250 SGTC_1330 1469-0054 61.8 µM -0.0800768711805029 0.467778196163426 no 1810 0.468088058894068 2597 7102664 SGTC_2309 7664088 163.95 µM -0.080378546767146 0.467668390594996 no 1811 0.467968094444659 2572 704922 SGTC_664 1222-0054 14.9 µM -0.0810917901905603 0.467408790060808 no 1812 0.467684477332619 2575 6813991 SGTC_2083 5306046 65.942 µM -0.0811081753379753 0.467402826490709 no 1813 0.467677962065944 2571 539837 SGTC_2140 5586273 200 µM -0.0815581751056738 0.467239046565046 no 1814 0.467499030936113 2538 854421 SGTC_864 0469-0573 172 µM -0.0815786741762746 0.467231585945823 no 1815 0.467490880150544 2545 689425 SGTC_500 h-89 112 µM -0.082061303685152 0.467055936680384 no 1816 0.467298982243051 2669 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_556 4058-0063 51.5 µM -0.0826900027482647 0.466827136160503 no 1817 0.467049017149702 2561 6615692 SGTC_445 e6 berbamine 66 µM -0.082713182827993 0.466818700514312 no 1818 0.467039801206256 2625 6610268 A calcium/calmodulin antagonist. SGTC_992 3909-8734 162 µM -0.0851087289792347 0.465946999418432 no 1819 0.466087475383479 2593 4288319 SGTC_597 k018-0003 82.8 µM -0.0867367441758135 0.465354683585877 no 1820 0.465440384418349 2645 6786234 SGTC_2078 5212016 200 µM -0.0873084827942331 0.46514668780006 no 1821 0.465213155738233 2532 1899708 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0891163543230004 0.464489055676052 no 1822 0.464494720118633 2693 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_1936 st074407 74.3 µM -0.0920425801341057 0.463424816851419 no 1823 0.463332104550935 2567 809813 SGTC_269 exalamide 29 µM -0.0927381168794576 0.463171895358922 no 1824 0.463055807294691 2601 3316 A derivative of salicylamide. SGTC_1311 1190-0148 100 µM -0.0928396161273314 0.463134987923896 no 1825 0.463015488893586 2655 1961333 SGTC_2651 TUB2.036 5 µM -0.0937127277800963 0.462817517807121 no 1826 0.462668679733982 2633 15992207 YFL037W TUB2 SGTC_922 1866-0035 480 µM -0.0937898470450345 0.462789477784157 no 1827 0.462638048508371 2584 3156169 SGTC_1383 3049-0032 20.7 µM -0.0939631328790451 0.462726472946955 no 1828 0.462569221411403 2668 712864 SGTC_1755 st041960 45.185 µM -0.0942557805245612 0.46262007158227 no 1829 0.462452987751031 2670 2257073 SGTC_1806 st050005 60.3 µM -0.0949756627108138 0.462358346901261 no 1830 0.462167078931711 2579 5194765 SGTC_2625 euphol 100 µM -0.0952935262693067 0.462242787701197 no 1831 0.462040842272058 2635 6708538 A triterpene alcohol. SGTC_2210 7115885 190.385 µM -0.0964440316896957 0.461824548519546 no 1832 0.461583961428109 2578 2927039 SGTC_2913 7966556 36.57 µM -0.0974074913123123 0.461474337893796 no 1833 0.46120139790734 2577 2976516 SGTC_1185 1319-0113 81.3 µM -0.0975282934079892 0.461430429305034 no 1834 0.461153433217837 2659 4672763 SGTC_1212 0520-0165 585 µM -0.0995075264422158 0.460711094149844 no 1835 0.460367656162124 2877 5403258 SGTC_3264 9137442 49.47 µM -0.0997475941689916 0.46062385230235 no 1836 0.460272357124001 2639 17015726 SGTC_1517 deoxycholic acid methyl ester 49.2 µM -0.0999751944073805 0.460541142954469 no 1837 0.460182009378365 2578 229346 A bile salt which induces apoptosis. SGTC_3149 9097855 49.47 µM -0.100100625398796 0.460495562380551 no 1838 0.460132219415612 2684 25236625 YMR079W SEC14 SGTC_1942 st076330 65.2 µM -0.100717484605971 0.46027140846523 no 1839 0.45988736562229 2722 24208414 SGTC_1198 1612-1005 86.7 µM -0.102125285023353 0.459759890222688 no 1840 0.459328615695966 2742 6998509 SGTC_2445 5742597 35.57 µM -0.102368047794078 0.459671690120172 no 1841 0.459232272286712 2605 1774255 SGTC_1854 st056233 32.9 µM -0.103385114877812 0.459302192890244 no 1842 0.458828662722722 2572 5393174 SGTC_588 3970-1144 52.9 µM -0.105739206538705 0.458447094268393 no 1843 0.457894636194057 2718 1888707 SGTC_2640 pentamidine 10.38 µM -0.10627877190921 0.458251129857495 no 1844 0.457680586875729 2656 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_3201 9113999 49.47 µM -0.107195652432087 0.45791815188831 no 1845 0.457316882207097 2791 16649224 SGTC_1519 esterone 74 µM -0.108476151886412 0.457453170099328 no 1846 0.456808998454526 2598 698 A steroid. SGTC_844 0330-0132 15.3 µM -0.108730404001591 0.457360851624823 no 1847 0.456708162953906 2664 2828079 SGTC_2564 betulinic acid 100 µM -0.108978719505258 0.457270690943802 no 1848 0.456609684583304 2685 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_722 3534-0461 190 µM -0.109959806713884 0.456914490314113 no 1849 0.456220625576451 2645 658262 SGTC_2355 9061122 103.12 µM -0.110869352961156 0.456584294777649 no 1850 0.45585997426734 2691 5302957 SGTC_304 1310-0298 97 µM -0.111363306380062 0.456404985804808 no 1851 0.455664128145854 2608 1550234 SGTC_348 k064-0012 10.7 µM -0.111573130158208 0.456328820808639 no 1852 0.455580938997583 2569 5066323 SGTC_958 1222-0007 33 µM -0.111621598665686 0.456311227207608 no 1853 0.455561722892429 2740 7312461 SGTC_2794 7785382 27.27 µM -0.112731385358461 0.455908408837073 no 1854 0.455121758964923 2578 2205081 SGTC_1855 st056195 39.6 µM -0.115484276029863 0.454909390855244 no 1855 0.454030641498684 2683 4028379 SGTC_2877 9040724 71.43 µM -0.11552818341433 0.454893459255062 no 1856 0.45401324144765 2653 6463895 SGTC_1994 st072947 40.9 µM -0.116129496233548 0.454675282870533 no 1857 0.453774956173004 2735 5286565 YDL195W SEC31 SGTC_249 wiskostatin 11.211 µM -0.116599174132602 0.454504877541155 no 1858 0.453588846104083 2594 2775510 A n-wasp and actin depolymerizer. SGTC_1452 4194-0072 190 µM -0.117349499853822 0.454232666869509 no 1859 0.453291550378302 2773 1343545 SGTC_1463 k081-0032 34.1 µM -0.117931318852555 0.454021603542027 no 1860 0.453061038770464 2651 977755 SGTC_1587 estradiol valerate 56.1 µM -0.118577897821766 0.453787062825052 no 1861 0.452804888385571 2635 13791 A steroid. SGTC_2891 9063876 19.48 µM -0.118801083944061 0.453706107800062 no 1862 0.452716474952174 2651 6472478 SGTC_804 1595-0054 20.9 µM -0.120629143959322 0.453043098752463 no 1863 0.4519923919296 2631 761523 Stimulates phospholipase C. SGTC_395 anisomycin 6.25 µM -0.120784841269963 0.452986635772246 no 1864 0.451930728552987 2663 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.124472199397983 0.451649711044912 no 1865 0.450470705421676 2595 5711223 A potent inhibitor of glutathione S-transferases. SGTC_3235 9132602 49.47 µM -0.125781349722583 0.451175183738672 no 1866 0.449952502637846 2709 4912240 SGTC_614 0462-0418 107 µM -0.12612748295095 0.451049732569985 no 1867 0.449815506469328 2639 5188303 SGTC_952 1185-0122 232 µM -0.126868097634027 0.450781323530028 no 1868 0.449522398483616 2599 678600 SGTC_1943 st076331 65.2 µM -0.127365079686927 0.450601222947406 no 1869 0.449325726741023 2623 24208415 SGTC_1824 st053723 68.6 µM -0.12760153664292 0.450515537233449 no 1870 0.449232157504982 2667 675225 SGTC_1242 0402-0103 60.1 µM -0.128352466071001 0.450243435685992 no 1871 0.448935023252866 2643 432868 SGTC_3293 9120939 62.045 µM -0.12993456440677 0.449670234269085 no 1872 0.448309098822205 2759 934087 SGTC_527 4476-4215 268 µM -0.132494735078917 0.448742895740057 no 1873 0.447296493555898 2654 4418754 SGTC_2394 5221648 200 µM -0.13314466150984 0.4485075253933 no 1874 0.447039487387369 2749 788586 SGTC_509 pifithrin 175 µM -0.133304069716861 0.448449798600845 no 1875 0.446976454579419 2648 4817 A p53 inhibitor. SGTC_2810 7959871 45.46 µM -0.135630700039988 0.4476073764518 no 1876 0.446056617291854 2752 2974535 SGTC_2520 obtusaquinone 4.71 µM -0.135675470713465 0.447591168271312 no 1877 0.446038919959706 2787 5967872 SGTC_984 1492-0255 2.91 µM -0.13610972731705 0.447433960318597 no 1878 0.445867268903742 2787 1585198 SGTC_463 ikarugamyin 104 µM -0.136536733534389 0.447279385175652 no 1879 0.445698493641386 2642 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_280 3448-3607 3.04 µM -0.136869939179583 0.447158771157554 no 1880 0.445566800120217 2647 626179 SGTC_1653 st012112 65 µM -0.137620424738914 0.446887127773249 no 1881 0.445270206258715 2781 720429 SGTC_1671 st016596 74.5 µM -0.138031120769342 0.446738484075152 no 1882 0.445107911067739 2691 2829167 SGTC_312 4092-0653 6.84 µM -0.138200813972474 0.446677068997641 no 1883 0.445040855907047 2749 1148278 SGTC_1496 4469-0713 57.4 µM -0.138471488693532 0.446579109507213 no 1884 0.444933900624491 2641 746691 SGTC_2688 kanamycin b 96.69 µM -0.138787936105567 0.446464588623183 no 1885 0.444808863656539 2741 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1395 3486-0190 4.35 µM -0.140582795449193 0.445815121922718 no 1886 0.444099770242684 2698 6748079 SGTC_2774 tamoxifen 10.92 µM -0.140763571769865 0.445749716357648 no 1887 0.444028360989111 2646 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_372 0155-0182 15.9 µM -0.141076913213036 0.445636351721856 no 1888 0.443904590906236 2664 771486 SGTC_2106 5357045 167.29 µM -0.141568593916517 0.445458474212308 no 1889 0.44371038772718 2768 668842 SGTC_1557 sumaresinolic acid 42.3 µM -0.142171763626178 0.445240277829615 no 1890 0.443472167283845 2651 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_1342 1486-1464 234 µM -0.142205674868433 0.44522801094424 no 1891 0.443458774725033 2662 3253938 SGTC_1008 4106-0037 6 µM -0.142413076780749 0.445152987541953 no 1892 0.443376866943251 2632 2905394 SGTC_545 4218-0007 221 µM -0.143424618839581 0.444787111081695 no 1893 0.442977420473586 2749 2840508 SGTC_1086 cerivastatin 2.18 µM -0.143662409475502 0.444701108626148 no 1894 0.442883528049736 2651 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1730 st033808 45.1 µM -0.143746617592665 0.444670653446714 no 1895 0.442850278963242 2654 1045166 SGTC_2173 5763948 167 µM -0.144293819743388 0.444472757216603 no 1896 0.442634229184213 2655 2867177 SGTC_1137 ixabepilone 100 µM -0.14453653570012 0.444384983165391 no 1897 0.442538404008024 2639 154225 A novel microtubule stabilizer. SGTC_441 propafenone 146 µM -0.145107109845132 0.444178655588799 no 1898 0.442313152430667 2647 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_3160 9100216 49.47 µM -0.145122165774291 0.444173211359231 no 1899 0.442307208894827 2625 17191039 SGTC_2161 5662504 8.5105 µM -0.146176412518606 0.443792021597214 no 1900 0.441891062808271 2692 2859334 SGTC_885 0865-0106 16.8 µM -0.146654078347329 0.443619326446873 no 1901 0.441702533376699 2664 2793380 SGTC_747 3448-8087 38.7 µM -0.148665214135626 0.442892338879498 no 1902 0.440908905623487 2724 5168703 SGTC_1818 st052136 56.3 µM -0.150182873164142 0.442343860955539 no 1903 0.44031016893615 2710 674169 SGTC_104 0074-0074 590.992 µM -0.150237694514638 0.442324050727259 no 1904 0.440288543729093 2643 3943124 SGTC_33 0986-0033 35.816 µM -0.150419315374485 0.442258421293488 no 1905 0.44021690158809 2665 2848082 SGTC_3026 9090633 49.47 µM -0.150503020382912 0.442228174682846 no 1906 0.440183883979971 2672 25236842 SGTC_2722 naftopidil 47.16 µM -0.152139504995104 0.441636902636832 no 1907 0.439538453189207 2671 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_703 3875-0075 71.8 µM -0.15251396836883 0.441501624929861 no 1908 0.439390787074802 2699 2850814 SGTC_2278 7948257 134.34 µM -0.15286498207524 0.441374824787224 no 1909 0.439252375773568 2697 1247028 SGTC_1690 st023502 41.2 µM -0.153205041383179 0.441251987540165 no 1910 0.439118291079954 2768 24207482 SGTC_3227 9130768 49.47 µM -0.153375586904536 0.441190384700489 no 1911 0.439051047956894 2695 17720899 SGTC_2028 5153890 36.43 µM -0.154822146256434 0.440667929580876 no 1912 0.438480765768149 2678 2830968 YPR165W RHO1 SGTC_2471 5466956 24.79 µM -0.156042126996725 0.440227388287925 no 1913 0.437999907684258 2723 724419 SGTC_2191 5911152 200 µM -0.157405929385766 0.439734999865088 no 1914 0.437462470367867 2706 2875902 SGTC_1214 0358-0031 63.7 µM -0.157610559412679 0.43966112808203 no 1915 0.437381841185877 2986 4301366 SGTC_2935 9038016 29.96 µM -0.159677106324049 0.438915219349125 no 1916 0.436567717994709 2739 6463195 SGTC_1170 0310-0127 64.8 µM -0.160085792820832 0.438767731810289 no 1917 0.436406746262755 2766 774975 SGTC_24 0417-1663 219 µM -0.160746087245388 0.438529461510356 no 1918 0.436146694513827 2756 4329390 SGTC_1157 4092-0394 27.6 µM -0.161192850570772 0.438368257527058 no 1919 0.435970755951798 2872 3659885 SGTC_3252 9135871 49.47 µM -0.161345627446136 0.438313133948492 no 1920 0.435910594241514 2843 17682838 SGTC_1204 4049-0315 18.3 µM -0.161361092130772 0.438307554186709 no 1921 0.43590450451589 2960 588402 SGTC_2375 9072683 200 µM -0.162044407075903 0.438061021836455 no 1922 0.435635442086613 2683 16798029 SGTC_430 0958-0115 16.4 µM -0.162101203445634 0.438040531425478 no 1923 0.435613079259419 2724 6833180 SGTC_2533 agelasine 13.65 µM -0.162439353367641 0.437918540609981 no 1924 0.435479941417903 2805 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_2543 pimpinellin 60.67 µM -0.163267122112224 0.437619940047274 no 1925 0.435154059639756 2695 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_712 r015-0009 80.6 µM -0.163905193961688 0.437389792975845 no 1926 0.43490288910533 2812 6813872 YLR060W FRS1 SGTC_946 3434-1334 87.4 µM -0.164016346216097 0.437349703470415 no 1927 0.434859137827409 2826 4047976 SGTC_1929 genistein trimethyl ether 50.5 µM -0.164228541933264 0.437273172204008 no 1928 0.434775616466399 2719 136420 SGTC_672 1441-0018 53.7 µM -0.165152361563713 0.436940011499579 no 1929 0.43441203012118 2694 251141 SGTC_3337 9144342 33.5465 µM -0.166188345902532 0.436566453597464 no 1930 0.434004365269047 2792 17682949 SGTC_2079 5212404 121 µM -0.166982112385441 0.436280273488242 no 1931 0.433692061779525 2748 758462 SGTC_1142 3253-1408 9.78 µM -0.167138839520412 0.436223771905485 no 1932 0.433630403151969 2683 256655 SGTC_2646 retinol 96.75 µM -0.167965253389442 0.435925863606545 no 1933 0.433305307226154 2780 445354 A vitamin A analog and teratogen. SGTC_1634 st006576 41 µM -0.168797738014541 0.435625803654145 no 1934 0.432977868799224 2826 3915356 SGTC_2737 bleomycin 30.5 nM -0.169123203799264 0.43550850314794 no 1935 0.43284986691527 2720 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_1603 st002045 67.8 µM -0.169303808628812 0.435443414151085 no 1936 0.432778840188297 2742 5887985 SGTC_1470 k295-0292 231 µM -0.169779965049515 0.435271818358841 no 1937 0.432591591868914 2801 5045612 SGTC_1826 st055655 41.6 µM -0.170065074424497 0.43516907734757 no 1938 0.432479479965439 2755 676168 SGTC_856 0433-0016 11.3 µM -0.17027974972938 0.435091720598001 no 1939 0.432395068029154 2772 3911780 SGTC_64 000l-0018 272.079 µM -0.171572151724392 0.434626065148034 no 1940 0.43188695123215 2692 6811119 SGTC_2102 5377816 72.7585 µM -0.172062829568804 0.434449296490357 no 1941 0.431694067299434 2885 1379702 SGTC_2629 bisabolol 100 µM -0.173245310812667 0.434023356798563 no 1942 0.431229304598338 2866 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_639 0833-0042 114 µM -0.174314168893376 0.4336384110177 no 1943 0.430809282273212 2729 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2139 5578692 56.4705 µM -0.175309061605438 0.433280160172662 no 1944 0.430418395951395 2752 650991 YMR113W FOL3 SGTC_1262 0737-0114 49.6 µM -0.175756543868269 0.433119044172092 no 1945 0.430242605533669 2777 765919 SGTC_746 1095-0025 46.6 µM -0.181337071710043 0.431110717106214 no 1946 0.428051504666719 2894 6749286 SGTC_1298 1079-1278 263 µM -0.181611802801894 0.431011892097598 no 1947 0.427943692798252 2761 2840950 SGTC_2999 9069765 71.4286 µM -0.182186442355501 0.430805199364964 no 1948 0.427718206185768 2800 2097066 SGTC_3195 9113082 49.47 µM -0.184023628650892 0.43014450723527 no 1949 0.426997459241556 2732 17018038 SGTC_2126 5251174 33.877 µM -0.184446269367521 0.429992544044844 no 1950 0.426831687357667 2851 790722 SGTC_1788 fluconazole 20 µM -0.186009030971672 0.429430733284278 no 1951 0.426218839616751 2819 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2177 5811945 192 µM -0.187893145191582 0.428753586769473 no 1952 0.425480208191205 2894 5343475 SGTC_2067 5224629 34.075 µM -0.188244851022971 0.428627207627841 no 1953 0.425342357437129 2896 2835000 SGTC_62 0180-0423 3.232 µM -0.188852279920868 0.428408956259731 no 1954 0.42510429778081 2785 30102 YGL099W LSG1 SGTC_326 k292-0812 17.5 µM -0.190503939180136 0.427815620093483 no 1955 0.424457128345961 2780 3579357 SGTC_1174 0739-0097 51.1 µM -0.191096482148784 0.427602796781553 no 1956 0.424225001845469 2809 728447 SGTC_546 peri-Naphthalide 147 µM -0.192150955183459 0.427224114451572 no 1957 0.423811981016383 2841 223824 A penicillin ester. SGTC_2021 4019055 173 µM -0.192916272804248 0.426949315576616 no 1958 0.42351227028365 2847 44827708 YER133W GLC7 SGTC_3114 9122766 49.47 µM -0.19294984778792 0.426937260781288 no 1959 0.423499122790046 2795 17176985 SGTC_1458 k015-0034 6.33 µM -0.193819160981024 0.426625165499975 no 1960 0.423158741605754 2802 3598957 SGTC_52 0329-0193 875 nM -0.19408395664042 0.426530109368295 no 1961 0.423055071759705 2958 3739292 SGTC_2698 st077697 67.5 µM -0.194274061262613 0.426461868396001 no 1962 0.422980647401363 2788 3154499 SGTC_2364 9055074 200 µM -0.194949988412732 0.426219251812788 no 1963 0.422716049893663 2842 6470630 SGTC_2306 7482397 179.52 µM -0.195479423714401 0.426029236355309 no 1964 0.422508822225555 2902 891448 SGTC_1995 st072814 61.1 µM -0.196085072849246 0.425811888652213 no 1965 0.422271789801837 2765 5769371 SGTC_2566 crystal violet carbinol 226 nM -0.19695916972561 0.425498243570343 no 1966 0.421929744846716 2937 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2237 6667747 47.222 µM -0.197189755124351 0.425415512334409 no 1967 0.421839523723642 2775 729940 YDL015C TSC13 SGTC_1836 st055642 81 µM -0.199484767565772 0.424592269362361 no 1968 0.420941778812236 2771 8571 SGTC_382 3229-0966 23.2 µM -0.200223489253965 0.424327352592044 no 1969 0.420652898674809 2929 5722370 SGTC_1703 st026983 48.3 µM -0.20109425900239 0.424015125294541 no 1970 0.420312435478221 2894 1104023 SGTC_2163 5671233 125 µM -0.201235336060132 0.423964544524931 no 1971 0.420257281213179 2919 701023 SGTC_2116 5511452 16.8835 µM -0.20132141496651 0.423933683018414 no 1972 0.4202236293183 2884 870744 SGTC_91 0417-1751 58.384 µM -0.201709288629831 0.423794626102772 no 1973 0.420072000292359 2731 6795624 SGTC_181 1447-1644 8.07 µM -0.203556250366576 0.423132600743508 no 1974 0.419350142197969 2842 534600 SGTC_759 3486-0358 89.3 µM -0.203718695183292 0.423074384343114 no 1975 0.419286665954949 2885 875103 SGTC_1057 3448-5381 134 µM -0.20759122440052 0.421687061070929 no 1976 0.417774078508321 2910 5497911 SGTC_607 4491-0986 66.8 µM -0.207773482800849 0.42162179128661 no 1977 0.41770291921388 2903 698981 YDR232W HEM1 SGTC_2081 5214970 32.255 µM -0.208077193653814 0.421513032130341 no 1978 0.417584347127773 2848 2063512 SGTC_2499 avocadenofuran 51.48 µM -0.208116373151518 0.421499002349373 no 1979 0.417569051562678 2758 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_2092 5303694 80.6725 µM -0.210588367453346 0.420614008476161 no 1980 0.416604245095234 2793 1963699 SGTC_3146 9095609 49.47 µM -0.211709088868467 0.420212913054406 no 1981 0.416166998467394 2848 17173999 SGTC_3190 9110366 49.47 µM -0.211971152814662 0.420119134822651 no 1982 0.416064769825784 2858 17123768 SGTC_1619 st003326 88.7 µM -0.212121137821012 0.420065465501629 no 1983 0.416006264662392 2942 2849032 SGTC_1785 bathophenanthroline 24 µM -0.212263276483615 0.420014605219288 no 1984 0.415950821866867 2793 72812 An iron chelator. SGTC_1040 k898-0338 155 µM -0.212687255746318 0.419862904222919 no 1985 0.415785453892977 2997 20969351 SGTC_517 1365-0151 113 µM -0.217181857871932 0.418255459153752 no 1986 0.414033311294154 2961 768657 SGTC_1932 st074806 40.9 µM -0.218831619287442 0.417665780985254 no 1987 0.413390607568316 3030 17251235 SGTC_1597 7-benzyloxygramine 47.5 µM -0.219675158168547 0.417364344293881 no 1988 0.413062076499845 2784 260807 SGTC_586 0957-0265 8.15 µM -0.220139674887988 0.41719837102727 no 1989 0.412881188261216 2835 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_2528 xanthyletin 44.79 µM -0.22150291961675 0.41671136474331 no 1990 0.412350431766377 2802 65188 An natural product with antifungal activity of unknown mechanism. SGTC_1412 3909-8563 178 µM -0.222784639991768 0.416253598811429 no 1991 0.411851561552371 2892 23767530 SGTC_1360 1598-0022 39.8 µM -0.22297124552797 0.416186962173682 no 1992 0.411778942949019 2908 761525 SGTC_1222 0366-0074 1.18 µM -0.225297838248471 0.415356341262788 no 1993 0.410873790636457 2944 286520 SGTC_1604 st002052 72.4 µM -0.226272992339255 0.415008312046998 no 1994 0.410494551337063 2923 6254834 YHR062C RPP1 SGTC_850 0388-0143 75.9 µM -0.229298541515963 0.413928929325468 no 1995 0.409318443494198 2826 67273 SGTC_1638 st008370 60.6 µM -0.229342127661646 0.413913384437234 no 1996 0.409301506387136 2775 24207134 SGTC_825 1988-2224 89.6 µM -0.230375493234866 0.413544876789433 no 1997 0.408900001305678 2804 1180859 SGTC_1892 st058411 7.36 µM -0.231069500911291 0.413297429998645 no 1998 0.408630404364271 2942 3934738 SGTC_3084 9116877 49.47 µM -0.231494921779366 0.413145764214972 no 1999 0.408465165070963 2810 27241325 SGTC_2976 9009005 19.48 µM -0.232192686544945 0.412897033828175 no 2000 0.408194178922543 3036 2993148 SGTC_977 1348-1378 135 µM -0.233623617597569 0.412387063044807 no 2001 0.407638595440997 2806 X977 SGTC_2954 9074818 52.69 µM -0.234306796730892 0.412143636332373 no 2002 0.40737340487387 2970 16648742 SGTC_547 1120-0019 610 nM -0.235065352966061 0.411873391257806 no 2003 0.407079004810151 2797 3676939 SGTC_2970 9090938 41.86 µM -0.235779231420062 0.411619101366812 no 2004 0.406801992392496 3058 17217104 SGTC_1649 st011737 51.3 µM -0.236530450102444 0.411351550633942 no 2005 0.406510540870152 2878 1761035 SGTC_1550 gossypolone 36.6 µM -0.237962886204329 0.41084149484964 no 2006 0.405954939966725 2821 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_2894 9048625 32.47 µM -0.238193576788776 0.410759365591243 no 2007 0.405865479376653 2988 4092861 SGTC_90 0870-0863 4.608 µM -0.239432577171468 0.410318330159417 no 2008 0.405385085783269 2806 1738164 SGTC_2848 9016370 25.97 µM -0.239625735780219 0.41024958349098 no 2009 0.405310205844434 2904 7894410 SGTC_3282 9108498 15.4605 µM -0.239799965463003 0.410187576141991 no 2010 0.405242666873058 2930 16459645 SGTC_957 1187-1561 14.1 µM -0.242058597534844 0.40938394565859 no 2011 0.404367379342879 2801 1538454 SGTC_1195 1502-0147 41.1 µM -0.242074437275558 0.409378311154538 no 2012 0.404361242653641 2833 817940 SGTC_1358 1509-0022 2.48 µM -0.24224587624935 0.409317328172971 no 2013 0.404294824656555 2895 3258434 SGTC_1466 k213-0079 57.5 µM -0.242443440467969 0.409247054837492 no 2014 0.404218288773714 2829 3657981 SGTC_1353 1498-1206 8.11 µM -0.242881536745982 0.409091234968288 no 2015 0.404048584455749 2846 6756808 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.243014032378431 0.409044112419555 no 2016 0.40399726349115 2836 368090 SGTC_730 1436-0052 41.2 µM -0.243757973210535 0.408779551613773 no 2017 0.403709135562892 2843 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1132 3456-3614 2.5 µM -0.243819428111417 0.408757698831755 no 2018 0.403685336443297 3105 3125502 SGTC_2655 perillic acid 100 µM -0.243819464389818 0.408757685931583 no 2019 0.403685322394173 2839 5702197 An apoptosis inducer. SGTC_83 0170-0301 39.027 µM -0.244151980760817 0.408639451174328 no 2020 0.403556557780028 2825 3089716 SGTC_1391 3442-0225 151 µM -0.247644644788642 0.407398048868965 no 2021 0.402204682430986 2843 5227075 SGTC_3173 9105693 49.47 µM -0.247964957924064 0.407284245878749 no 2022 0.402080759863038 3013 17096658 SGTC_611 3453-1652 23.7 µM -0.24818553846477 0.407205881100481 no 2023 0.401995427507887 2945 1560575 SGTC_2245 6637752 200 µM -0.248732416748334 0.407011609836368 no 2024 0.401783885883517 3003 681890 SGTC_2917 7979103 53.79 µM -0.250560364568573 0.406362421876124 no 2025 0.401077014392385 3008 2980565 SGTC_808 0711-0032 135 µM -0.251243174478302 0.406119990729772 no 2026 0.40081305319736 2849 4252555 SGTC_65 0798-0905 34.986 µM -0.252257890002191 0.405759783254818 no 2027 0.400420867344633 3250 3602145 SGTC_2691 st077356 60.2 µM -0.254589150454853 0.404932526447241 no 2028 0.399520219905344 3023 2839272 SGTC_2272 7805186 180 µM -0.255581317606631 0.40458058069882 no 2029 0.399137072884098 2989 2956062 YPR165W RHO1 SGTC_896 0964-0007 44.5 µM -0.255962999806166 0.404445209310259 no 2030 0.398989703819117 2835 6756758 SGTC_3351 9150312 21.596 µM -0.257135700978743 0.404029358513955 no 2031 0.398537009235372 2892 4904905 SGTC_342 k048-0088 23.3 µM -0.257192348636436 0.404009273466845 no 2032 0.398515145148138 2819 6820570 SGTC_1611 st001856 99.4 µM -0.257753423973427 0.403810351738836 no 2033 0.398298606185337 2886 647478 SGTC_2387 9077560 195.08 µM -0.258145183070993 0.403671473555376 no 2034 0.398147430952992 2858 5303272 SGTC_2919 7978188 46.38 µM -0.260053410066973 0.402995183065288 no 2035 0.397411287566697 3037 2980291 SGTC_418 lividomycin a 100 µM -0.261693032369201 0.402414319791797 no 2036 0.39677905637658 2973 72394 An antibiotic. SGTC_1306 1185-0270 9.02 µM -0.26170905480924 0.402408644638509 no 2037 0.39677287952931 2984 1548076 SGTC_2280 7785178 200 µM -0.262372590254989 0.4021736382529 no 2038 0.396517101235845 2882 2954328 SGTC_3339 9145883 14.936 µM -0.262440952004803 0.402149428369763 no 2039 0.396490751815806 3010 2030670 SGTC_1751 st044839 27.194 µM -0.263852166356239 0.401649739685432 no 2040 0.395946917742174 2855 5291326 SGTC_3041 9091929 49.47 µM -0.265157396399802 0.401187721448064 no 2041 0.395444106621528 3050 25236887 SGTC_3003 9075612 71.4286 µM -0.26557476012129 0.401040014423258 no 2042 0.395283363116566 2943 6501993 SGTC_792 4534-1957 155 µM -0.266207674768749 0.400816049884988 no 2043 0.395039636309112 2918 1717904 SGTC_139 0099-0334 718.624 µM -0.26687141435022 0.400581212587099 no 2044 0.394784083350826 2846 97690 SGTC_1685 st024049 53.0905 µM -0.271209139666959 0.399047373010343 no 2045 0.393115091946673 2975 1941139 SGTC_1594 piperine 70.1 µM -0.272583951977016 0.398561556979454 no 2046 0.392586524705704 2870 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_3225 9130819 49.47 µM -0.272875393639117 0.39845859069795 no 2047 0.392474500991589 3017 4547121 SGTC_2185 6113692 200 µM -0.272957613784569 0.398429543614926 no 2048 0.392442899001122 3017 874150 SGTC_3317 9138495 8.753 µM -0.273640864070647 0.398188183828064 no 2049 0.39218031357674 2890 17020139 SGTC_400 oxethazaine 37.5 µM -0.274668457487434 0.397825257379316 no 2050 0.391785483338502 2956 4621 A local anesthetic. SGTC_754 3474-0146 171 µM -0.274997154167396 0.397709186610505 no 2051 0.391659212349083 2880 24762078 SGTC_2597 laccaic acid a 100 µM -0.275792941102695 0.397428212461806 no 2052 0.39135355285832 3030 5491415 A textile dye. SGTC_2059 5238311 157 µM -0.277431656214484 0.396849787435896 no 2053 0.390724338540257 2883 703021 SGTC_443 clozapine 122 µM -0.277475210324685 0.396834417025041 no 2054 0.390707619046314 2887 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1797 st048695 56.8 µM -0.278257956911958 0.396558210127898 no 2055 0.390407173801321 3029 592262 YIL048W NEO1 SGTC_2398 5228213 48.84 µM -0.278362487861946 0.396521328335835 no 2056 0.390367056151762 3105 80771 YMR134W ERG29 SGTC_1225 1216-0074 20.6 µM -0.279654620796211 0.396065499936921 no 2057 0.389871248483811 2909 4241466 SGTC_567 1080-0542 68.4 µM -0.27998642532647 0.395948471469593 no 2058 0.389743959784279 2922 5950415 SGTC_412 gemfibrozil 100 µM -0.280501391625694 0.395766859864767 no 2059 0.389546428970241 2942 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_758 0868-0029 16 µM -0.280594603255595 0.395733989618954 no 2060 0.38951067789393 3009 762687 SGTC_818 4072-2707 53.5 µM -0.281373740438752 0.395459262901022 no 2061 0.389211878470672 2852 882871 SGTC_1210 3013-0140 750 nM -0.283061708922942 0.394864257160045 no 2062 0.388564766759424 3033 905973 SGTC_608 k048-0125 159 µM -0.284787790431838 0.394256070131315 no 2063 0.387903363442454 3027 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_3075 9116269 49.47 µM -0.286253315873859 0.393739892604969 no 2064 0.387342055589723 3114 17015205 YNL244C SUI1 SGTC_334 1502-1024 68.5 µM -0.28759953147272 0.393265902037328 no 2065 0.386826651782028 2993 3296216 SGTC_1301 naphtanilide LB 4.81 µM -0.287653663126265 0.393246846065561 no 2066 0.386805931437502 3038 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_109 0132-0036 33.701 µM -0.288002456130256 0.393124066562356 no 2067 0.386672429285088 2867 67274 A color developer. SGTC_823 0417-1665 178 µM -0.288476234349626 0.392957307727556 no 2068 0.386491109939172 3009 3429856 SGTC_282 k297-0036 65.7 µM -0.290417963674693 0.392274070021836 no 2069 0.385748251299122 3060 5061378 SGTC_2099 5377090 177.372 µM -0.292039146059904 0.391703877575352 no 2070 0.385128346844693 3004 2243829 SGTC_103 0844-0104 51.839 µM -0.292160047312393 0.391661364222782 no 2071 0.385082128606035 3028 5375804 SGTC_1414 3917-0015 5.4 µM -0.294124856473856 0.390970646348925 no 2072 0.384331248891439 3020 6618702 SGTC_272 doxorubicin 8.13 µM -0.294222875000687 0.390936197459321 no 2073 0.384293801058424 2923 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2101 5377231 179.231 µM -0.294402435032534 0.390873092796221 no 2074 0.384225203215678 3059 2844213 SGTC_2593 nobiletin 86.24 µM -0.294832690261312 0.390721895388579 no 2075 0.384060846313912 3004 72344 An anti-infammatory. SGTC_392 N-ethylmaleimide 8.33 µM -0.294877110957085 0.390706286305972 no 2076 0.384043878856453 2959 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_1420 4'-methoxyflavone 42 µM -0.295269875251094 0.390568279692213 no 2077 0.383893863607456 3011 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_1641 st009299 47.1 µM -0.295760359974155 0.39039595615449 no 2078 0.383706548737362 2959 4046054 SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.296026402150274 0.390302495725352 no 2079 0.383604959269126 2858 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_1951 sophoraflavanone G 9.2 µM -0.296147370283196 0.390260001801643 no 2080 0.383558769658676 2936 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_3080 9117754 49.47 µM -0.296776527019635 0.390039011538879 no 2081 0.383318563627708 3143 9550191 SGTC_2870 9038528 12.99 µM -0.298739460864716 0.389349762953946 no 2082 0.382569422863698 3050 6463316 SGTC_1881 5652484 16 µM -0.299361523384152 0.389131409498175 no 2083 0.382332108318779 3082 2255129 SGTC_1790 st045711 43.5 µM -0.300279310002854 0.388809316308149 no 2084 0.381982056843526 3102 585119 SGTC_1376 2910-0861 41.3 µM -0.301041098353689 0.388542028052538 no 2085 0.381691577656635 2913 1112859 SGTC_2736 butenafine 14.65 µM -0.30288850879911 0.387894047547367 no 2086 0.380987414458716 2959 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_422 cantharidin 155 µM -0.302899722827591 0.387890115170055 no 2087 0.380983141294523 2885 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1308 1187-1617 41.4 µM -0.304035288699789 0.387491970544217 no 2088 0.38055050321866 2927 2882570 SGTC_1993 st073995 70.8 µM -0.304177309190349 0.387442184569284 no 2089 0.380496405474228 2969 3098394 SGTC_2370 9071495 200 µM -0.304652771731697 0.38727552233458 no 2090 0.380315311643038 3017 21791103 SGTC_2831 7999036 19.48 µM -0.306087842360386 0.386772618105966 no 2091 0.37976888218358 3208 2988270 SGTC_654 1124-0271 80.9 µM -0.307218821543766 0.38637641314847 no 2092 0.379338410151356 2959 5403748 SGTC_451 chloral hydrate 100 µM -0.307580927666756 0.386249585036583 no 2093 0.379200617304629 3069 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_2389 9091542 195.52 µM -0.308380726776556 0.385969497506035 no 2094 0.378896322820265 3002 3626624 YOL127W RPL25 SGTC_871 0574-0004 149 µM -0.308381016572293 0.385969396031097 no 2095 0.378896212577112 2942 9551173 SGTC_223 busulfan 5 mM -0.309260322309536 0.385661534101192 no 2096 0.378561755351477 3032 2478 A DNA alkylator. SGTC_2710 st078562 53.7235 µM -0.309313757570508 0.385642827702979 no 2097 0.378541433371129 2908 17250908 SGTC_3231 9132313 49.47 µM -0.31016709908162 0.385344129455171 no 2098 0.378216944349153 3005 4905967 SGTC_2768 sulfasalazine 50.2 µM -0.311529857570096 0.384867259195999 no 2099 0.377698924151291 3077 5384001 An antioxidant and salicylic acid derivative. SGTC_1352 1496-0991 99 µM -0.311901913559437 0.384737095819921 no 2100 0.377557534096537 2945 3000039 SGTC_1721 st082152 9.2685 µM -0.311923798444814 0.384729439821401 no 2101 0.377549217834454 2885 5296051 SGTC_2639 lactacystin 53 µM -0.313047127706062 0.384336525512035 no 2102 0.377122428748752 3100 3870 A proteasome inhibitor. SGTC_1718 roemerine 11.9335 µM -0.313242898380979 0.384268061653977 no 2103 0.377048064483996 3105 235224 An aporphine alkaloid with mutagenic activity. SGTC_1853 st056710 91.2 µM -0.31409957472077 0.383968511948054 no 2104 0.376722706261742 3123 269167 SGTC_516 3992-2719 87.3 µM -0.315684307818849 0.383414569107009 no 2105 0.376121069314963 2892 5350887 YDR037W KRS1 SGTC_147 4466-0538 29.23 µM -0.315955533461429 0.383319786134254 no 2106 0.376018129812928 3179 6742687 YHR072W ERG7 SGTC_53 0973-0023 39.979 µM -0.316411697281354 0.383160390104756 no 2107 0.37584501978033 2996 674768 SGTC_449 xestospongin c 11.1929 µM -0.316487869774092 0.38313377529319 no 2108 0.375816115443601 3068 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1558 st069300 45.6 µM -0.316598844083883 0.383095001648884 no 2109 0.375774006491835 3073 24208000 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.316773121166047 0.383034112824625 no 2110 0.375707880431938 2963 16623 A steroid. SGTC_2988 9073640 71.4286 µM -0.317472909333622 0.382789650360787 no 2111 0.375442396155482 3174 9102229 SGTC_670 4204-0025 119 µM -0.317923422435821 0.382632293798594 no 2112 0.375271512566721 3064 719039 SGTC_1644 st010134 20.9 µM -0.318041226780185 0.382591149939674 no 2113 0.375226832376277 3072 3818134 SGTC_1889 st059080 5.18 µM -0.319472968949683 0.382091211632013 no 2114 0.374683942969507 3140 176925 Isolated from Daphnopsis sellowiana. SGTC_1001 4048-4355 44.4 µM -0.320377097656312 0.381775607527222 no 2115 0.3743412423805 2953 21824233 SGTC_2882 9058044 58.44 µM -0.320760698488642 0.381641727754624 no 2116 0.374195872446143 3051 18076804 SGTC_311 1315-0136 58 µM -0.32090107468976 0.381592738870115 no 2117 0.374142679744133 3147 6759207 SGTC_829 1635-0120 117 µM -0.323133730591611 0.380813835746973 no 2118 0.373296983014268 3109 285054 SGTC_3219 9131112 49.47 µM -0.325023153004477 0.380155052945725 no 2119 0.372581774323618 3079 17612988 YMR079W SEC14 SGTC_106 0092-0003 11.579 µM -0.325228863666062 0.380083348984043 no 2120 0.372503932518273 3031 1072148 SGTC_2009 4012297 12.05 µM -0.325373784082774 0.380032836974044 no 2121 0.372449097131376 3082 45595307 SGTC_959 1222-0044 107 µM -0.325497936256836 0.37998956536227 no 2122 0.372402122145715 3118 6083612 SGTC_57 miconazole 162.5 nM -0.327320086672359 0.379354651834842 no 2123 0.37171290074797 2989 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_2325 6158266 200 µM -0.327424385255166 0.379318319665092 no 2124 0.371673462624462 3052 3623240 SGTC_1757 st041620 31.8375 µM -0.327971541088563 0.379127736666725 no 2125 0.371466590234954 3042 5289815 SGTC_1234 0326-0494 15.5 µM -0.327988414189872 0.379121859966357 no 2126 0.371460211328061 3124 1547813 SGTC_435 c-PAF 6.7 µM -0.32812767185688 0.379073359245208 no 2127 0.371407566059804 3138 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_917 harmaline 728.087 nM -0.328298812769033 0.379013756820893 no 2128 0.37134287087571 3077 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2296 7971656 126.45 µM -0.328434843742477 0.378966384018229 no 2129 0.371291450645192 3050 666570 SGTC_1871 st057448 67.3 µM -0.32977324371829 0.378500383109056 no 2130 0.370785652940605 3194 691747 SGTC_339 3091-4833 71.4 µM -0.329986457923724 0.378426162988923 no 2131 0.370705097276357 2988 3240077 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.330040217318691 0.378407449987042 no 2132 0.370684787029966 3113 61125 An anti-inflammatory. SGTC_749 1000-0129 128 µM -0.330437332480963 0.378269227788526 no 2133 0.37053476847944 3153 708470 SGTC_539 4859-0462 2.54 µM -0.33066016534206 0.378191674116462 no 2134 0.370450597330287 3143 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_562 3772-2733 112 µM -0.332671537322828 0.377491868351816 no 2135 0.369691118427412 3118 2876874 YIL048W NEO1 SGTC_615 k087-0205 167 µM -0.332716385682501 0.377476269078329 no 2136 0.369674189804632 3005 9642773 SGTC_3180 9109287 49.47 µM -0.332793904155308 0.377449306872171 no 2137 0.369644929999372 3108 18891271 SGTC_3209 9113616 49.47 µM -0.33354133455841 0.377189368884314 no 2138 0.3693628467298 3204 16649353 SGTC_1333 1482-0047 286 µM -0.333834103494483 0.377087566177381 no 2139 0.369252373701816 3130 3811116 SGTC_420 mitomycin C 81.9 mM -0.335586155350207 0.37647851493237 no 2140 0.368591482792797 2995 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1246 0422-0085 105 µM -0.336673416400581 0.376100713857548 no 2141 0.368181552625447 3146 264295 SGTC_2989 9073649 71.4286 µM -0.338080128472407 0.375612086244945 no 2142 0.367651402486835 3059 21367202 SGTC_744 1594-0068 283 µM -0.338173801635541 0.37557955553467 no 2143 0.367616108652647 3015 668392 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -0.340887697871654 0.374637461626035 no 2144 0.366594063207027 3059 1241132 A phosphatase inhibitor. SGTC_1256 0570-0116 285 µM -0.341742405888085 0.374340915383034 no 2145 0.366272378026537 3031 410638 SGTC_2331 7980721 200 µM -0.344011527363925 0.373553990636446 no 2146 0.365418808507291 3052 2981221 SGTC_166 k072-0058 166.424 µM -0.345016145483451 0.373205760078344 no 2147 0.365041116410209 3136 5846229 SGTC_2844 9010103 25.97 µM -0.345994783411675 0.37286663458419 no 2148 0.36467331757163 3182 2480525 SGTC_1269 0831-0796 3.05 µM -0.346188998369913 0.372799345358704 no 2149 0.364600341088179 3134 927758 SGTC_2249 haloperidol 116.36 µM -0.34643474796792 0.372714206603772 no 2150 0.36450800743966 2986 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_398 bronopol 33.3 µM -0.348045199135714 0.372156427681639 no 2151 0.363903119498707 2981 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_861 0443-0273 110 µM -0.348851204194192 0.371877368854402 no 2152 0.363600509940768 3112 6149169 SGTC_308 4092-1169 104 µM -0.349415437381309 0.371682057445802 no 2153 0.363388722732567 3024 2268590 YDL196W YDL196W SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.349511521017262 0.371648801028542 no 2154 0.363352661509858 3182 688798 SGTC_1742 st038235 28.8875 µM -0.351278633937766 0.371037339884663 no 2155 0.362689661256062 3131 564103 YBR002C RER2 SGTC_3164 9100705 49.47 µM -0.3515167901546 0.370954957285972 no 2156 0.36260033922907 3148 17174235 SGTC_1996 st072960 66.8 µM -0.352236715370325 0.370705957940122 no 2157 0.362330372112021 3146 1719405 SGTC_697 0508-1955 564 µM -0.352570027000662 0.370590694326839 no 2158 0.362205405665438 3180 6243113 SGTC_767 0929-0023 86 µM -0.352965007297798 0.370454119902825 no 2159 0.362057337183356 3073 1204563 SGTC_3086 9117350 49.47 µM -0.353475952197829 0.370277472007654 no 2160 0.361865827023694 3088 2679265 SGTC_292 k038-0015 474 µM -0.354019113688242 0.370089715936109 no 2161 0.36166227950651 3141 46368540 SGTC_2752 diclazuril 33.15 µM -0.354980126713428 0.369757595876739 no 2162 0.361302239769676 3140 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_2697 mebhydrolin 72.4 µM -0.357187506369018 0.368995107486964 no 2163 0.360475719152466 3204 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_2118 5526350 200 µM -0.360123307455052 0.367981801461766 no 2164 0.359377461840283 3128 743594 SGTC_3194 9111903 49.47 µM -0.36068871501511 0.367786753495811 no 2165 0.359166080875649 3241 17087251 SGTC_1679 SEC14.276 6.7 µM -0.361208467365042 0.367607485223429 no 2166 0.358971806403849 3157 1005053 YMR079W SEC14 SGTC_2198 6589944 200 µM -0.361664222450656 0.36745031404059 no 2167 0.358801483015256 3085 5290268 SGTC_1257 0669-0121 16 µM -0.363373831963295 0.366860938076489 no 2168 0.358162823414215 3106 4307855 SGTC_1910 st062352 60.4 µM -0.363941243686538 0.366665396106745 no 2169 0.357950942744765 2970 2245730 SGTC_1911 st060208 74.3 µM -0.364873014031891 0.366344363601841 no 2170 0.357603099639421 3140 688783 SGTC_1827 berberine 7.24 µM -0.364909461713631 0.366331807802934 no 2171 0.357589495603409 3042 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_660 4031-1742 102 µM -0.365245615242026 0.366216013601942 no 2172 0.357464035395039 3063 6738706 SGTC_480 am 92016 50 µM -0.365389396193514 0.366166489355117 no 2173 0.357410377747857 3114 2129 K+ channel blocker. SGTC_2354 9060492 162 µM -0.365683627006715 0.366065150756007 no 2174 0.357300582468916 3202 6471895 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.366064028342754 0.365934147263521 no 2175 0.357158649275848 3181 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_1130 3454-2858 15.9 µM -0.368065053946289 0.365245287106253 no 2176 0.35641236375431 3097 715628 YIL048W NEO1 SGTC_1930 st074634 34.3 µM -0.369927824535783 0.364604412201443 no 2177 0.355718134406357 3020 684253 YOR116C RPO31 SGTC_294 k038-0071 157 µM -0.370904457645382 0.364268558526082 no 2178 0.355354347444129 3108 24152826 SGTC_323 4013-0906 34.3 µM -0.372842576060705 0.363602369119416 no 2179 0.354632806396938 3149 2910086 SGTC_2809 7964133 12.99 µM -0.372924328323834 0.363574277462218 no 2180 0.354602382331392 3096 1253665 SGTC_2522 biochanin a 4.94 µM -0.373691930449002 0.363310550335618 no 2181 0.354316764832662 3176 5280373 A possible chelator. SGTC_1041 0206-0046 107 µM -0.374149853733073 0.363153251243636 no 2182 0.354146414906516 3123 50494 SGTC_1284 0929-0043 16 µM -0.375654541700222 0.362636545533638 no 2183 0.353586868547823 3114 1239883 SGTC_1926 methyl fluorone black 53.6 µM -0.376648469096842 0.362295370678401 no 2184 0.353217431403323 3082 72721 Reacts with homocysteine. SGTC_883 0850-0245 24.6 µM -0.380557411846528 0.360954652611287 no 2185 0.351765843926651 3255 6823229 YPR165W RHO1 SGTC_3014 9081533 49.47 µM -0.381458901106518 0.360645694750942 no 2186 0.351431381027429 3197 21367265 SGTC_2135 5326629 150.42 µM -0.381463640626516 0.360644070665623 no 2187 0.351429622914595 3103 5020077 SGTC_256 clotrimazole 625 nM -0.383346382506721 0.35999911298964 no 2188 0.350731476401766 3143 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_306 1672-3436 11.6 µM -0.383438785413559 0.359967469414747 no 2189 0.350697225086455 3178 6797378 SGTC_1056 3448-1962 115 µM -0.38353272327986 0.359935301173358 no 2190 0.35066240604618 3152 715507 SGTC_1465 k213-0056 144 µM -0.386082813224158 0.35906242374318 no 2191 0.349717668994567 3066 24048857 YMR208W ERG12 SGTC_962 1254-0300 21.5 µM -0.386806856057235 0.358814722915493 no 2192 0.349449600588236 3035 7340576 SGTC_135 0933-0004 26.348 µM -0.387493160698941 0.358579987423199 no 2193 0.349195573603908 3198 21230617 YGL099W LSG1 SGTC_2666 tannic acid 100 µM -0.387876029855843 0.358449058607932 no 2194 0.34905388877263 3168 16134267 A thiamine antagonist. SGTC_979 1426-2828 121 µM -0.391885631241802 0.357078907297225 no 2195 0.347571360090091 3225 747872 SGTC_2871 9038510 12.99 µM -0.394135499573638 0.35631089290815 no 2196 0.346740501501257 3287 4945164 SGTC_1148 3909-7663 27.7 µM -0.394712209194179 0.356114121143574 no 2197 0.346527645635689 3203 4084526 SGTC_1114 scopoletin 1.73284 µM -0.395290960884348 0.35591669114695 no 2198 0.346314084774813 3222 5280460 A coumarin with genotoxic properties. SGTC_236 1509-0011 5.31 µM -0.396858398258676 0.355382184198185 no 2199 0.345735941843729 3244 3107280 SGTC_1027 k015-0025 8.67 µM -0.397587473789716 0.355133661238614 no 2200 0.345467147718345 3052 3598955 SGTC_533 1222-0222 6.71 µM -0.398796150599459 0.354721790403764 no 2201 0.345021706830678 3271 3982874 SGTC_3218 9131285 49.47 µM -0.399441430339563 0.354501973223689 no 2202 0.344783985887969 3279 17156417 SGTC_1752 st044819 83.042 µM -0.399850903479484 0.354362509648572 no 2203 0.344633167823346 3102 441209 YML126C ERG13 SGTC_121 0557-0495 61.343 µM -0.399912128088438 0.354341658669455 no 2204 0.344610619559558 3137 3104427 SGTC_1504 k297-0033 30 µM -0.400311458995068 0.354205671120874 no 2205 0.344463564488355 3044 4388117 SGTC_2308 7584454 197.62 µM -0.400381067963403 0.354181968489263 no 2206 0.344437933135688 3294 893577 SGTC_3320 9137005 35.139 µM -0.40137367385515 0.353844036594056 no 2207 0.344072514443557 3162 4908713 SGTC_993 3909-8757 62.7 µM -0.402491930286541 0.35346346497476 no 2208 0.343661013041205 3114 4288324 YLR208W SEC13 SGTC_848 0368-0089 85.6 µM -0.402514248537271 0.353455870985512 no 2209 0.343652802146784 3220 762535 SGTC_2201 6605497 169.863 µM -0.402644478149437 0.353411560330441 no 2210 0.3436048920853 3136 670741 SGTC_764 1951-2361 146 µM -0.40347785942196 0.353128049223148 no 2211 0.343298359661447 3121 5438930 SGTC_1351 1496-0003 46.5 µM -0.40361873930668 0.353080130815041 no 2212 0.343246551717423 3246 3891978 SGTC_1908 st060353 56.5 µM -0.403991289125201 0.352953424206377 no 2213 0.343109562394616 3312 4227716 SGTC_637 1181-0519 7.26 µM -0.40503932281939 0.352597068641612 no 2214 0.342724303282097 3167 6252091 YGR060W ERG25 SGTC_1279 0874-0590 65.2 µM -0.406355813444821 0.352149614817308 no 2215 0.342240590644627 3166 3523074 SGTC_891 0929-0073 133 µM -0.406623507771853 0.352058654867896 no 2216 0.342142264466423 3225 5603632 SGTC_164 4100-3994 89.624 µM -0.407927366716762 0.351615737279879 no 2217 0.341663500203349 3259 4615967 SGTC_2069 5228469 200 µM -0.408037052432552 0.351578486493238 no 2218 0.341623236279751 3211 2835210 SGTC_985 1493-0307 8.71 µM -0.411975930121001 0.350241736135276 no 2219 0.340178532794978 3278 3278274 SGTC_23 0213-0011 39.996 µM -0.415127792151132 0.349173411667733 no 2220 0.339024177558129 3297 627608 SGTC_1626 st003712 1.76 µM -0.419997519004842 0.347525166399464 no 2221 0.337243633063644 3270 24207035 SGTC_2667 digitoxin 100 µM -0.420325158208238 0.347414374120995 no 2222 0.33712396680368 3216 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1145 3546-0597 10.2 µM -0.420850763779581 0.347236666093368 no 2223 0.336932030146334 3181 875334 SGTC_2412 st077135 33.4 µM -0.421189417408036 0.347122184582685 no 2224 0.336808385667106 3356 13258915 SGTC_2025 5147754 141 µM -0.421208001997412 0.347115902485056 no 2225 0.336801600831938 3170 315777 YLR208W SEC13 SGTC_3186 9110464 49.47 µM -0.423399033290219 0.346375569070648 no 2226 0.336002075038384 3269 17018021 SGTC_2771 fluoxetine 41.05 µM -0.425612388463876 0.345628288039441 no 2227 0.3351951558124 3304 3386 A selective serotonin reuptake inhibitor. SGTC_2909 7941780 10.49 µM -0.426017447196421 0.345491595623032 no 2228 0.335047566372488 3304 1243215 SGTC_3040 9091894 49.47 µM -0.426621746490293 0.345287704301194 no 2229 0.33482742788214 3116 25236966 SGTC_2764 methyldopa 94.69 µM -0.427469809481257 0.345001642528086 no 2230 0.334518585113243 3329 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_1681 tripelennamine 100 µM -0.427837312961521 0.344877706710752 no 2231 0.334384784535359 3239 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_3063 1327-0034 4 µM -0.428169838285819 0.344765581167284 no 2232 0.334263736923679 3231 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_2835 9006588 71.43 µM -0.428300514366436 0.344721521708365 no 2233 0.334216172248048 3327 2345538 SGTC_2492 derrusnin 100 µM -0.428858922312577 0.344533269579097 no 2234 0.33401294781492 3107 1715307 Part of coumarin class of compounds. SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.429054108618197 0.344467476875655 no 2235 0.333941924078617 3256 7104 SGTC_188 3229-0966 278.469 µM -0.429652100983543 0.344265937041462 no 2236 0.333724365661866 3288 5722370 SGTC_3336 9143619 71.43 µM -0.429680088460657 0.344256505576544 no 2237 0.333714184774707 3292 45595730 SGTC_2367 9070478 135.38 µM -0.429957133608822 0.344163149704305 no 2238 0.333613411828616 3164 572802 SGTC_1344 1488-0097 29.1 µM -0.430495562453207 0.343981742563841 no 2239 0.333417597001541 3261 747966 SGTC_455 paf C-16 10 µM -0.430780858712437 0.343885635260633 no 2240 0.333313859366025 3156 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2269 7935389 174.42 µM -0.430844562833981 0.343864176730487 no 2241 0.333290697413996 3188 97605 SGTC_2627 acetyl isogambogic acid 100 µM -0.431013938007651 0.343807125689958 no 2242 0.333229117997101 3245 6857789 A caspase activator and apoptosis inducer. SGTC_876 0720-0963 56.8 µM -0.431288678549027 0.343714591747197 no 2243 0.333129240649888 3332 765861 SGTC_1840 st055363 71 µM -0.431452711500948 0.34365934911926 no 2244 0.333069614844206 3197 676033 SGTC_822 1487-0950 154 µM -0.432210795360207 0.343404086821559 no 2245 0.332794106992653 3314 1958375 SGTC_2045 5106652 78.05 µM -0.433163921097417 0.343083251288551 no 2246 0.332447843822159 3261 673349 SGTC_536 3852-0578 10.6 µM -0.433614957740138 0.342931465415023 no 2247 0.332284035522315 3297 2869208 SGTC_2971 9092186 9.93 µM -0.433624026887582 0.342928413664615 no 2248 0.332280742101464 3110 25236400 SGTC_128 0906-2981 13.371 µM -0.4340592471999 0.342781974928061 no 2249 0.332122708995049 3314 6740226 SGTC_3152 9099253 49.47 µM -0.436920933475231 0.341819691423715 no 2250 0.331084344952379 3211 25236131 SGTC_1779 st039427 55 µM -0.437425190398017 0.341650233956406 no 2251 0.330901509383025 3361 1124498 SGTC_618 k072-0232 33.2 µM -0.43918645885495 0.341058603504761 no 2252 0.33026321799059 3248 5872756 YGL099W LSG1 SGTC_814 3342-0569 96 µM -0.43919702283801 0.341055056117595 no 2253 0.330259391044326 3291 4346283 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.439428778813495 0.340977235960408 no 2254 0.330175438764435 3161 2333 A French combination drug. SGTC_1572 epiandrosterone 68.9 µM -0.440110657608074 0.340748310601875 no 2255 0.329928481656335 3175 441302 A steroid. SGTC_2075 5212009 200 µM -0.440411569433121 0.34064730491676 no 2256 0.329819523510916 3295 780898 SGTC_2490 carminic acid 95.39 µM -0.440529042374026 0.340607876416771 no 2257 0.329776991268303 3269 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_2338 7999974 200 µM -0.441222830602601 0.340375049563145 no 2258 0.329525843264297 3185 315925 SGTC_2068 5226020 147 µM -0.441287967230411 0.340353193628953 no 2259 0.329502268063796 3213 1810509 SGTC_2369 9071472 200 µM -0.442191316080236 0.340050139409052 no 2260 0.329175384744365 3282 17296037 SGTC_3045 9092950 49.47 µM -0.443103715026064 0.339744153943531 no 2261 0.328845359099743 3329 44120432 SGTC_2890 9046729 58.44 µM -0.444089186518154 0.33941378119334 no 2262 0.328489052096622 3159 903329 SGTC_2105 5350118 200 µM -0.444216199346436 0.339371209959861 no 2263 0.328443140682934 3214 2133313 SGTC_2318 6029776 164 µM -0.444491588877407 0.339278913946751 no 2264 0.328343604338882 3337 818325 SGTC_195 4234-0266 16.654 µM -0.444748128671031 0.339192944043541 no 2265 0.3282508919741 3189 2303354 SGTC_2418 pentamidine 31.67 µM -0.445036860933115 0.339096196027987 no 2266 0.328146558043341 3286 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_834 0312-0008 75.7 µM -0.445481917638776 0.338947087811861 no 2267 0.327985762249161 3220 6385573 YIL048W NEO1 SGTC_1398 3558-0053 112 µM -0.447083589294382 0.338410685543115 no 2268 0.327407353740891 3111 4532369 SGTC_352 k048-0007 5.11 µM -0.449605055881533 0.337566906922369 no 2269 0.326497620941284 3283 6811911 SGTC_250 brefeldin a 552.239 µM -0.450311729966167 0.337330573101461 no 2270 0.326242841114304 3195 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_1955 wogonin 32.4 µM -0.450323782741192 0.337326542834421 no 2271 0.326238496385453 3390 5281703 A flavanone. SGTC_366 0181-0206 4.31 µM -0.45148307334946 0.336938980754884 no 2272 0.325820710935176 3392 274874 SGTC_3087 9117406 49.47 µM -0.453793090374476 0.336167235967514 no 2273 0.324988878644282 3289 42546093 SGTC_2608 thymoquinone 42.66 µM -0.454605770762049 0.335895894574215 no 2274 0.324696441196921 3285 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_298 1391-0729 10 µM -0.455978337860747 0.335437809913332 no 2275 0.324202777733282 3192 3237558 SGTC_1177 0983-0204 23.6 µM -0.456840901444319 0.335150060428276 no 2276 0.323892702350535 3333 766818 SGTC_2462 5162487 171.77 µM -0.459060558971904 0.33441003211438 no 2277 0.323095339325054 3306 2259986 SGTC_1971 st069429 63.5 µM -0.459079808180329 0.334403617284329 no 2278 0.323088428018586 3298 1246522 YGL099W LSG1 SGTC_2330 7979373 200 µM -0.460091094435447 0.334066672531404 no 2279 0.322725418026907 3177 1863007 SGTC_725 1497-0963 19 µM -0.46126621185624 0.333675309750019 no 2280 0.322303811547841 3321 3549977 SGTC_2223 6903751 107.57 µM -0.463963372870782 0.332777728060374 no 2281 0.321336993778498 3281 5598863 SGTC_27 0485-0001 32.618 µM -0.463998140695598 0.332766164000672 no 2282 0.321324538870272 3275 2054479 SGTC_2795 7780010 54.55 µM -0.466214969655141 0.332029157641017 no 2283 0.320530817635711 3332 953673 SGTC_807 1315-0151 48 µM -0.466480823656076 0.331940815442977 no 2284 0.320435685333885 3398 4011080 SGTC_718 1130-0073 349 µM -0.46655513953022 0.331916122252224 no 2285 0.320409094500913 3394 6740020 SGTC_2090 5301565 104.445 µM -0.467949090455463 0.331453084770469 no 2286 0.319910498315505 3239 2056344 SGTC_1834 st055981 52.8 µM -0.468386022637642 0.331307999220278 no 2287 0.319754280853524 3372 471719 YDL150W RPC53 SGTC_1503 4585-0012 61.3 µM -0.469506154477771 0.330936169437959 no 2288 0.319353943377769 3363 2922052 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.470676184986478 0.330547953707136 no 2289 0.318935996778383 3345 756377 SGTC_2350 9023895 38.85 µM -0.471157158088574 0.330388419827087 no 2290 0.318764255087418 3347 2997209 SGTC_3103 9120822 49.47 µM -0.471549272851114 0.33025838215762 no 2291 0.318624270952598 3439 17141819 SGTC_2980 9014342 25.29 µM -0.471862512332411 0.330154516755671 no 2292 0.318512463719765 3367 2996599 SGTC_3030 9087619 49.47 µM -0.472141044426925 0.330062170782863 no 2293 0.318413058769067 3256 25236973 SGTC_2679 rapamycin 1 nM -0.474168808529143 0.329390187723092 no 2294 0.317689767083147 3305 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_1862 st057513 3.81 µM -0.476013878962842 0.328779226087846 no 2295 0.317032245101466 3199 5393163 SGTC_1847 st056231 15 µM -0.476202045729681 0.328716943743133 no 2296 0.316965221105968 3223 5393180 SGTC_554 4483-2211 187 µM -0.476911675321055 0.328482102384915 no 2297 0.316712508888351 3294 747107 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.4770925462088 0.328422256684533 no 2298 0.316648111092394 3282 688788 SGTC_542 3381-0244 89.3 µM -0.479499033262597 0.327626429087646 no 2299 0.315791827895855 3379 1112843 SGTC_1203 3992-3522 103 µM -0.480377359904521 0.327336160329493 no 2300 0.315479544948384 3521 5322312 SGTC_97 0535-0701 19.132 µM -0.483037626854045 0.326457634589074 no 2301 0.31453450997143 3310 2832013 YGL099W LSG1 SGTC_2181 6316240 54.2555 µM -0.483126691953943 0.326428238370075 no 2302 0.314502891393973 3315 12779990 SGTC_3038 9091290 49.47 µM -0.485037327933252 0.325797886754587 no 2303 0.313824933560672 3384 25236843 SGTC_561 1550-0330 72.9 µM -0.486722253141112 0.325242413854452 no 2304 0.313227586523809 3250 6812934 SGTC_3094 9117742 49.47 µM -0.486784076406349 0.325222039819989 no 2305 0.313205677975406 3277 17149698 SGTC_2402 5553605 200 µM -0.486972222887124 0.325160038822042 no 2306 0.313139007839716 3419 6758546 SGTC_150 3970-0969 77.2 µM -0.487267768087572 0.325062655876909 no 2307 0.313034293056195 3354 6615640 SGTC_391 gliotoxin 8.33 µM -0.487412627158037 0.3250149287837 no 2308 0.312982973464997 3409 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_56 0957-0365 83.25 µM -0.487663526682079 0.324932271061433 no 2309 0.312894095225905 3340 6752360 SGTC_629 3448-6466 76.7 µM -0.487739843040759 0.32490713068857 no 2310 0.312867063199812 3323 573744 SGTC_1121 fusaric acid 630.51 nM -0.487928685443825 0.324844925063119 no 2311 0.312800177636287 3235 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_384 k007-0144 5.16 µM -0.488139533926543 0.324775476296352 no 2312 0.312725505082651 3289 6824886 SGTC_79 0052-0007 94.094 µM -0.48818642223171 0.324760033166723 no 2313 0.312708900508516 3398 2801472 SGTC_926 2268-1401 59.4 µM -0.489694219881294 0.324263585718445 no 2314 0.312175146309845 3344 2931578 SGTC_1430 4049-0248 69.1 µM -0.490325697957637 0.324055762156498 no 2315 0.31195172264785 3356 22774488 SGTC_2663 amphotericin b 100 µM -0.49062139347193 0.323958465671489 no 2316 0.311847126202115 3321 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_457 grayanotoxin iii 135 µM -0.490639103567076 0.323952638673528 no 2317 0.311840862087408 3346 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_397 arbidol 50 µM -0.491422639025814 0.3236948820348 no 2318 0.31156377770021 3380 131410 A RNA synthesis inhibitor. SGTC_898 1000-0849 28.3 µM -0.491741775754323 0.323589921080159 no 2319 0.311450950825999 3332 6751807 SGTC_2796 7949634 45.45 µM -0.491879601255963 0.323544595956449 no 2320 0.311402229784828 3279 2971588 SGTC_1375 2910-0797 186 µM -0.493168439937575 0.323120876839506 no 2321 0.310946787817608 3269 742508 SGTC_2114 5491910 81.25 µM -0.493368838018072 0.323055014481037 no 2322 0.310875998346163 3368 2849228 SGTC_130 0136-0219 337.655 µM -0.494031864989652 0.322837145155646 no 2323 0.310641837769544 3274 234244 SGTC_1409 3909-8004 61.9 µM -0.494173618902489 0.322790572991115 no 2324 0.310591784628977 3309 2119279 SGTC_1009 4106-0057 9.87 µM -0.494587621266804 0.322654571592452 no 2325 0.310445620955158 3399 2928005 SGTC_1489 4065-0444 182 µM -0.496855693313492 0.32190992239528 no 2326 0.309645408904926 3356 2877968 SGTC_2718 lomofungin 53.02 µM -0.497231631369257 0.321786564071059 no 2327 0.309512858942968 3394 5351222 A RNA synthesis inhibitor. SGTC_1969 st069479 40.1 µM -0.497313810695446 0.321759600797417 no 2328 0.309483887078993 3381 3895485 SGTC_1508 1080-0625 72.9 µM -0.498622114728963 0.321330468978062 no 2329 0.309022811343955 3338 767111 SGTC_1 0258-0098 57.368 µM -0.500904264553273 0.320582480589324 no 2330 0.308219250533544 3282 6790032 YDR047W HEM12 SGTC_1650 st011916 45.8 µM -0.501736863292255 0.320309772414333 no 2331 0.307926315132203 3399 242528 SGTC_671 0560-0003 407 µM -0.502324874069528 0.320117234664535 no 2332 0.307719507461175 3271 3238678 SGTC_799 1310-0557 151 µM -0.503599221935075 0.319700129549508 no 2333 0.307271519726482 3402 5354492 SGTC_1792 st045773 43.6 µM -0.50525674012486 0.319157950528492 no 2334 0.306689261356642 3297 2919270 SGTC_734 2023-0417 80 µM -0.505331640150526 0.319133459633052 no 2335 0.306662961734009 3364 3935732 SGTC_810 3825-7150 143 µM -0.505380709806133 0.31911741520932 no 2336 0.306645732460823 3421 22330411 YGL099W LSG1 SGTC_108 0509-0257 621.132 µM -0.505921689279295 0.318940552310168 no 2337 0.306455812784677 3312 536624 SGTC_2467 5474540 200 µM -0.506772939043922 0.318662335937366 no 2338 0.306157072905923 3277 5413519 SGTC_591 4299-0174 154 µM -0.507709362291154 0.318356400111999 no 2339 0.30582859085114 3300 5509088 SGTC_2828 7998861 71.43 µM -0.509877934100571 0.317648388724373 no 2340 0.305068490921605 3359 2988188 SGTC_646 4092-0839 27.3 µM -0.51264153352748 0.316747074167143 no 2341 0.304101047230037 3445 877796 SGTC_811 0416-0114 265 µM -0.512801140598027 0.316695053394155 no 2342 0.304045215917589 3398 6612453 SGTC_431 k089-0097 107 µM -0.512877916195452 0.316670031195376 no 2343 0.304018361076029 3328 5499420 SGTC_119 0121-0043 24.815 µM -0.513358425708402 0.316513445746805 no 2344 0.303850310773019 3432 1092378 SGTC_2229 7354935 190 µM -0.514048844253062 0.316288514021226 no 2345 0.303608920807478 3347 318112 SGTC_2468 5987765 72.9 µM -0.515765177097144 0.315729643865541 no 2346 0.303009213336415 3329 26772094 SGTC_1680 diphenhydramine 100 µM -0.516171884444464 0.315597273990024 no 2347 0.302867182587216 3300 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_837 0091-0265 12.5 µM -0.516412072138894 0.315519111897871 no 2348 0.302783318000143 3293 759367 SGTC_1546 5-methoxyflavanone 78.7 µM -0.516720310647196 0.315418816741469 no 2349 0.30267570784631 3391 147795 SGTC_1428 4049-0204 61.7 µM -0.517078366612516 0.315302328970876 no 2350 0.302550727274259 3406 X1428 SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.517120592807583 0.315288592564951 no 2351 0.30253598961171 3349 77254 SGTC_346 4513-0042 7.16 µM -0.518534122065118 0.314828911413856 no 2352 0.30204282959673 3344 2827372 SGTC_467 ro 31-8220 72.8 µM -0.518543039085534 0.314826012499205 no 2353 0.302039719722783 3306 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_3297 9117502 71.43 µM -0.519754710695498 0.314432205416869 no 2354 0.30161727448402 3381 7453720 SGTC_600 1495-0418 41.6 µM -0.520562448745343 0.314169798564871 no 2355 0.301335807041671 3329 5377768 SGTC_3260 9137109 49.47 µM -0.521145588361005 0.313980414529516 no 2356 0.301132677555662 3321 17478346 SGTC_585 0kpi-0023 191 µM -0.521764064820683 0.313779607807379 no 2357 0.300917306362808 3374 64601 SGTC_2187 6125751 200 µM -0.522647209985218 0.313492964151664 no 2358 0.300609890428462 3366 874498 SGTC_1292 0kpi-0043 232 µM -0.527553600704399 0.311902544307238 no 2359 0.298904602266778 3362 3333905 SGTC_1127 asiatic acid 681.4 nM -0.530417658582615 0.310975768241735 no 2360 0.297911192673921 3305 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_133 0724-0033 378.92 µM -0.531987059022304 0.310468435854906 no 2361 0.297367479224882 3276 280309 SGTC_2451 5856223 45.7 µM -0.534714071294099 0.309587745372177 no 2362 0.296423794893645 3343 2179896 SGTC_2551 apiole 73.87 µM -0.535146750343474 0.30944811164359 no 2363 0.296274192297887 3327 10659 A possible DNA adduct former. SGTC_1106 tegaserod maleate 11.7 µM -0.535504387521968 0.309332716112171 no 2364 0.296150562235923 3369 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_2866 9034245 58.44 µM -0.535612295613652 0.309297902082839 no 2365 0.296113264599435 3342 6462273 SGTC_171 k064-0041 9.68 µM -0.537881758514261 0.308566109812547 no 2366 0.295329341362639 3334 53325 SGTC_123 0083-0120 66.675 µM -0.539329318628119 0.308099738150288 no 2367 0.294829821091691 3356 16001701 SGTC_2549 cedrol 20.94 µM -0.540141068863594 0.307838345754349 no 2368 0.294549874984949 3417 6708665 A sedative which affects the nervous system. SGTC_743 1275-0778 158 µM -0.54116983420679 0.307507212207059 no 2369 0.294195263797286 3415 2849257 YMR203W TOM40 SGTC_3083 9117465 49.47 µM -0.542939120062238 0.306938090658547 no 2370 0.29358585998688 3409 16420915 SGTC_1657 st012939 43.4 µM -0.542999583481139 0.306918649757151 no 2371 0.293565044606722 3463 24207257 SGTC_2813 7971799 71.43 µM -0.545145183798199 0.306229123210671 no 2372 0.292826834403146 3421 2234054 SGTC_156 3474-0145 5.642 µM -0.545605071665334 0.306081419291607 no 2373 0.29266871868816 3429 2265471 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -0.545710323196243 0.30604761969261 no 2374 0.292632537355155 3400 6708739 YPR165W RHO1 SGTC_2525 harmine 47.85 µM -0.54590931815731 0.305983720622532 no 2375 0.292564136400013 3345 5280953 A monoamine oxidase inhibitor SGTC_1821 st053465 65.6 µM -0.546122703664576 0.305915207178758 no 2376 0.292490797207934 3392 675086 SGTC_3266 9136860 49.47 µM -0.546752084266906 0.305713166321327 no 2377 0.292274533029796 3399 4871271 YPR165W RHO1 SGTC_2322 7413319 38.22 µM -0.547174257075642 0.305577675482938 no 2378 0.292129510104394 3443 1840400 SGTC_2385 9074692 200 µM -0.547456013448302 0.305487264271973 no 2379 0.292032741045212 3376 17046906 SGTC_3327 9140648 26.9345 µM -0.548268328067139 0.305226671628269 no 2380 0.291753835634336 3449 8029710 SGTC_299 1273-0059 1.44 µM -0.548575247142202 0.305128236873689 no 2381 0.29164848835139 3422 2848077 SGTC_1886 st057356 49.9 µM -0.549011878213154 0.304988225318052 no 2382 0.291498649127081 3321 24207747 SGTC_3315 9136395 68.55 µM -0.549432665737207 0.304853321213989 no 2383 0.291354280935476 3509 16876844 SGTC_213 1246-0773 967 nM -0.550331034865726 0.304565393655487 no 2384 0.291046170751621 3386 6251622 SGTC_2056 5235370 200 µM -0.550944388068957 0.304368883303211 no 2385 0.290835898848663 3349 5511916 SGTC_2257 7960413 200 µM -0.551564573666589 0.304170241355545 no 2386 0.290623356875726 3391 2974689 YIL048W NEO1 SGTC_685 1278-0033 54.9 µM -0.55332369786035 0.30360711833414 no 2387 0.290020888327048 3489 3590572 SGTC_495 decylubiquinone 155 µM -0.553951653362418 0.303406212802616 no 2388 0.289805966702464 3420 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_2934 9036370 36.88 µM -0.554181499763771 0.303332691531874 no 2389 0.289727319044959 3408 6462800 SGTC_264 promethazine 12.5 mM -0.555181382563731 0.303012950408915 no 2390 0.289385300910825 3517 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_3224 9130643 49.47 µM -0.555668604053918 0.302857202069956 no 2391 0.289218711557286 3513 17644395 SGTC_2137 5261020 140 µM -0.556092649989875 0.302721678012584 no 2392 0.289073759707801 3412 763655 SGTC_218 alverine citrate 93.75 µM -0.559947924536066 0.301490789956577 no 2393 0.28775747922565 3483 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1299 1079-1439 3.74 µM -0.560306982823351 0.301376266792237 no 2394 0.287635032650166 3374 323161 SGTC_1037 k284-1091 78.7 µM -0.560738739372586 0.301238582148351 no 2395 0.287487827026691 3469 3334711 SGTC_1475 4092-1048 11.7 µM -0.562511515835617 0.300673551311597 no 2396 0.286883779908635 3463 2881759 SGTC_2310 7668677 200 µM -0.563610305484878 0.3003235782409 no 2397 0.286509685882716 3540 2197143 SGTC_364 0083-0097 67.7 µM -0.565815680519179 0.299621705274452 no 2398 0.285759542921337 3486 5207356 SGTC_2862 9027634 71.43 µM -0.566203754604214 0.299498275459158 no 2399 0.285627638942536 3396 5012562 SGTC_3242 9133940 49.47 µM -0.566234500844299 0.299488497376972 no 2400 0.285617189724677 3508 17248444 SGTC_29 0299-0004 12.984 µM -0.566586908594813 0.299376433133626 no 2401 0.285497435704469 3377 16871 A napthoquinone isolated from Swertia calycina. SGTC_1815 st051655 58.2 µM -0.566588955291246 0.299375782347961 no 2402 0.285496740272771 3444 5984156 SGTC_2037 5169046 200 µM -0.567754292147239 0.299005345780437 no 2403 0.285100910174659 3473 5718022 SGTC_1435 4092-0789 56.7 µM -0.568122978161134 0.298888191454797 no 2404 0.284975733055547 3477 2248285 SGTC_1819 st053448 58.6 µM -0.568949264018262 0.29862570515833 no 2405 0.284695285826729 3389 2857616 SGTC_947 3447-0010 211 µM -0.569954503571695 0.298306512043071 no 2406 0.284354278191382 3477 748350 SGTC_988 1497-1057 103 µM -0.570194166013015 0.29823043510767 no 2407 0.284273006274556 3521 3533044 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.570984637042077 0.29797957561699 no 2408 0.284005028425647 3493 5024745 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.572710317785262 0.297432257636889 no 2409 0.283420425124256 3499 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3283 9109332 35.8195 µM -0.574569570572225 0.296843090212236 no 2410 0.28279121835104 3370 17027281 SGTC_643 k048-0106 28.4 µM -0.575359004965699 0.296593092744719 no 2411 0.28252426171998 3486 6763920 SGTC_2507 purpurin 79.67 µM -0.575623189760496 0.296509452454129 no 2412 0.282434951555815 3358 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_1287 0971-0001 34.6 µM -0.577954117393946 0.295771955029534 no 2413 0.281647548441609 3496 4665869 SGTC_665 3914-0008 307 µM -0.578254202931041 0.295677070270751 no 2414 0.281546254478838 3415 1069549 SGTC_2127 5253358 187.912 µM -0.583627545225049 0.293980433633465 no 2415 0.279735461903758 3418 20612 SGTC_1014 4130-3005 69.3 µM -0.584260039575987 0.293781019561841 no 2416 0.279522686414514 3439 743608 SGTC_1923 st058458 19.1 µM -0.584351553331107 0.293752172107509 no 2417 0.279491907060998 3549 3534982 SGTC_127 0180-0333 59.125 µM -0.585044511471659 0.293533776697093 no 2418 0.279258893849608 3501 771601 SGTC_50 0929-0078 56.389 µM -0.58529076996455 0.293456183015525 no 2419 0.279176110028122 3354 1377751 SGTC_1514 1189-1591 158 µM -0.585652069399724 0.293342358239032 no 2420 0.279054674905931 3537 767698 YMR146C TIF34 SGTC_2244 6635614 200 µM -0.586462536619303 0.293087100848322 no 2421 0.278782365003941 3323 836499 SGTC_1085 doxorubicin 7.67 µM -0.588560814569031 0.292426725387502 no 2422 0.278077963419789 3519 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1606 st000094 49.2 µM -0.588630125455241 0.292404923493223 no 2423 0.278054710257504 3549 1242210 SGTC_2746 daunorubicin 9.88 µM -0.589407037946896 0.292160595658675 no 2424 0.277794128222243 3413 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_682 0kpi-0099 17 µM -0.589545572777331 0.292117038423775 no 2425 0.277747675174047 3511 1714895 YML126C ERG13 SGTC_1808 st050063 61.5 µM -0.590877180238838 0.291698517148993 no 2426 0.277301358472459 3520 4011993 SGTC_1402 3909-7673 35.9 µM -0.590995214616816 0.291661432693584 no 2427 0.27726181365719 3492 5328014 SGTC_479 n-linoleoylglycine 10 µM -0.591009599665051 0.291656913298851 no 2428 0.277256994452587 3459 6433346 An anti-infammatory. SGTC_2329 6138490 200 µM -0.591556405427348 0.291485145864609 no 2429 0.277073836793473 3487 720019 SGTC_3305 9127027 53.8275 µM -0.592044284177821 0.291331928943329 no 2430 0.276910467286508 3422 41905295 SGTC_1794 st048918 76.9 µM -0.592476298723677 0.291196287398754 no 2431 0.276765843673678 3461 672303 SGTC_1093 fluphenazine 7.97 µM -0.59249432684703 0.291190627668964 no 2432 0.276759809282359 3505 6602611 An atypical antipsychotic. SGTC_1884 5633444 25 µM -0.593683364017933 0.290817456065206 no 2433 0.276361955961085 3540 5724239 SGTC_3157 9099274 49.47 µM -0.595299727003298 0.290310529871321 no 2434 0.275821569187215 3515 17217662 SGTC_1652 st011932 78 µM -0.595489275633636 0.290251110464479 no 2435 0.275758232814296 3491 1551076 SGTC_1388 3346-4487 254 µM -0.595613744764171 0.290212095175919 no 2436 0.27571664619752 3508 3345614 SGTC_2050 5263056 171 µM -0.595921372126222 0.290115678834386 no 2437 0.275613877463866 3513 763468 YGL055W OLE1 SGTC_1868 st057644 42.7 µM -0.596417131201911 0.289960329986765 no 2438 0.275448299420283 3455 688665 SGTC_2802 7925815 54.55 µM -0.597903351954139 0.289494848388711 no 2439 0.274952211584447 3464 1262923 SGTC_3029 9088683 49.47 µM -0.599266950720982 0.289068080722854 no 2440 0.274497441509563 3526 25236615 SGTC_2960 9079389 5.97 µM -0.599307416053623 0.289055420745653 no 2441 0.274483951700367 3517 16457355 SGTC_1443 4112-3303 14 µM -0.599565604060322 0.288974650230105 no 2442 0.274397888025484 3508 704433 SGTC_1128 3448-9350 235 µM -0.602888796760035 0.287935984920429 no 2443 0.273291334694678 3448 619386 SGTC_986 1493-0483 84 µM -0.603234267959798 0.287828108974932 no 2444 0.273176427001352 3490 40079 SGTC_2312 7706453 155.7 µM -0.603703762155206 0.287681536535716 no 2445 0.27302030621641 3507 976098 SGTC_2395 5646831 180.19 µM -0.604571579675284 0.287410703543348 no 2446 0.272731847566908 3544 6808628 SGTC_1289 0976-0073 69.1 µM -0.605529808083862 0.287111794828803 no 2447 0.272413512517271 3551 3391136 SGTC_640 3381-0960 37.1 µM -0.605587273672002 0.287093873755711 no 2448 0.27239442762207 3553 1745025 SGTC_3027 9089541 49.47 µM -0.605937360058172 0.286984708144079 no 2449 0.272278174789199 3541 9943819 SGTC_2664 lyso-paf C-16 73.48 µM -0.610553627921436 0.285547083701898 no 2450 0.27074756505711 3521 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_58 0957-0393 9 µM -0.611717443625656 0.285185183368837 no 2451 0.270362359388458 3519 6997992 SGTC_279 1273-0055 2.93 µM -0.616981253903086 0.283551083976059 no 2452 0.268623545271785 3543 2847562 SGTC_1700 st030840 7.9285 µM -0.617462021979066 0.283402058031846 no 2453 0.268465011892031 3542 5499307 SGTC_1162 k048-0130 20.1 µM -0.617811327954593 0.283293805570833 no 2454 0.268349857681486 3525 6797406 SGTC_2532 xanthone 78.9 µM -0.617946005095113 0.283252073443469 no 2455 0.268305465879809 3469 7020 An insecticide. SGTC_116 0155-0182 31.788 µM -0.618211387367019 0.283169848617957 no 2456 0.268218002328542 3528 771486 SGTC_2197 6588183 93.1375 µM -0.61831299603084 0.283138369687733 no 2457 0.268184518379095 3532 884136 SGTC_2906 7926292 26.41 µM -0.618755169249615 0.283001401516846 no 2458 0.268038829853121 3546 2966319 SGTC_1077 5-fluorocytosine 377 nM -0.620751663517424 0.282383361117804 no 2459 0.267381515565858 3533 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2052 5265182 7.135 µM -0.622640678206817 0.28179919082431 no 2460 0.266760336771013 3540 1239884 SGTC_1335 1486-0900 202 µM -0.625922891084806 0.280785566867262 no 2461 0.265682759587586 3574 X1335 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM -0.628245240226494 0.280069437916577 no 2462 0.264921649026559 3501 390807 SGTC_1651 st011928 86.1 µM -0.630215276233313 0.279462644497825 no 2463 0.264276872936511 3555 720198 SGTC_1081 sertraline 6 µM -0.631942046525769 0.278931305294294 no 2464 0.263712373540671 3573 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_2435 5706476 10.6 µM -0.632010095523137 0.278910376215125 no 2465 0.263690140209106 3569 5725375 SGTC_1117 retinoic acid 1.10837 µM -0.633683179007573 0.27839604484643 no 2466 0.263143802355158 3603 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.634147316796598 0.27825344375671 no 2467 0.262992342795266 3600 551469 SGTC_1183 1254-0324 198 µM -0.63513852163407 0.277949026562988 no 2468 0.262669037573643 3583 5799357 SGTC_3346 9158254 43.5805 µM -0.635578460252652 0.277813965439327 no 2469 0.262525606231328 3541 17639500 SGTC_1796 st049173 110.4 µM -0.636195987513406 0.277624438687935 no 2470 0.262324344060411 3548 94134 SGTC_1774 st048371 48.465 µM -0.640039238005059 0.276446319527395 no 2471 0.261073545058252 3539 4242727 SGTC_2316 5844804 197.44 µM -0.641402283976216 0.276029077903044 no 2472 0.260630674721593 3611 776813 SGTC_2784 7567673 72.73 µM -0.642702003144561 0.275631509459532 no 2473 0.260208740493765 3605 3471247 SGTC_3013 9080133 71.4286 µM -0.644252896494659 0.27515747856716 no 2474 0.259705727404254 3658 17050193 SGTC_1693 xanthone 101.9 µM -0.644843009993082 0.274977215736628 no 2475 0.259514463281412 3588 7020 An insecticide. SGTC_1379 2144-0755 36.5 µM -0.645764545324903 0.274695829423111 no 2476 0.259215926220755 3626 5392327 SGTC_3309 9129340 25.759 µM -0.646040407888745 0.27461162375982 no 2477 0.259126593374013 3596 17158987 SGTC_1258 0671-0043 57.1 µM -0.646062877166509 0.274604765686338 no 2478 0.25911931782666 3564 4298767 SGTC_295 k015-0027 31 µM -0.646497985124982 0.274471978685554 no 2479 0.258978450789719 3556 3887424 SGTC_3159 9100096 49.47 µM -0.648713166228294 0.273796437583427 no 2480 0.258261896296856 3563 25236875 SGTC_852 0418-0143 439 µM -0.649464233992169 0.273567578933749 no 2481 0.258019178542854 3635 5369229 SGTC_2030 5175110 200 µM -0.64989827761258 0.273435364221981 no 2482 0.257878965411458 3637 2831986 SGTC_2854 9024559 71.43 µM -0.650569352212641 0.273231009417186 no 2483 0.257662259809989 3568 3163529 SGTC_2916 7875993 68.79 µM -0.650997972001871 0.273100526258411 no 2484 0.25752389800512 3591 1299250 SGTC_1917 st066507 28.5 µM -0.651654775812173 0.272900637810516 no 2485 0.257311951524434 3547 3156428 SGTC_1727 st034309 9.9045 µM -0.653270169643826 0.272409325655292 no 2486 0.256791059991605 3631 870305 SGTC_887 0885-0007 9.62 µM -0.655321124990395 0.271786173776976 no 2487 0.256130511223873 3619 5719458 SGTC_1704 st028805 70.8 µM -0.655402165647466 0.271761565371358 no 2488 0.256104428765602 3584 2876101 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.655646795112154 0.271687289123006 no 2489 0.256025704615599 3604 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_2769 toremifene 3.73 µM -0.65769174865083 0.271066780474273 no 2490 0.255368112765597 3631 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1448 4255-0083 152 µM -0.6578877447791 0.271007345704998 no 2491 0.255305133050261 3647 5399660 SGTC_2381 9035592 200 µM -0.658811213569134 0.27072739627839 no 2492 0.255008502794819 3564 4749657 SGTC_1645 Cervolide 78 µM -0.65969301113203 0.270460214307797 no 2493 0.254725426265192 3561 23173 A fragrance. SGTC_3234 9132280 49.47 µM -0.659943926729033 0.27038421173572 no 2494 0.254644906887268 3626 17612295 SGTC_543 3844-1095 191 µM -0.660464616586475 0.270226528353098 no 2495 0.254477858886387 3610 4230703 SGTC_1050 3232-1156 69.3 µM -0.661820426152669 0.269816156941999 no 2496 0.254043156891268 3576 700529 SGTC_3170 9103054 49.47 µM -0.662346139312742 0.269657120026809 no 2497 0.253874706706852 3571 16432970 SGTC_3353 9151644 39.2805 µM -0.663315130380441 0.269364107319959 no 2498 0.253564374110624 3613 4909158 SGTC_1754 st042065 16.137 µM -0.664708202999955 0.268943136729 no 2499 0.253118573059406 3584 1126236 YIL048W NEO1 SGTC_2120 5538279 151.968 µM -0.664731615528461 0.268936064554235 no 2500 0.253111084275116 3630 2058197 SGTC_2109 5483026 200 µM -0.664826139021804 0.26890751298471 no 2501 0.253080850962018 3638 759335 SGTC_1107 amlodipine 47 µM -0.665450559117868 0.268718940194332 no 2502 0.25288117810373 3533 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_235 0330-0087 5 mM -0.666053996485101 0.268536767263352 no 2503 0.252688293777502 3634 46494818 YHR062C RPP1 SGTC_2486 5283202 22.39 µM -0.666401784218066 0.26843180112675 no 2504 0.252577161187389 3591 1377751 SGTC_2352 9027995 87.8 µM -0.666826693367791 0.268303586910605 no 2505 0.252441420063406 3576 2997347 SGTC_778 3456-2434 196 µM -0.66816678991961 0.267899421351403 no 2506 0.252013565890848 3657 5539063 SGTC_2003 4023581 200 µM -0.668378917746335 0.267835472917672 no 2507 0.251945874689146 3642 16641307 SGTC_34 0469-0683 81.75 µM -0.669110048151876 0.267615123980462 no 2508 0.251712640348976 3614 3690923 SGTC_1682 st012968 530 nM -0.669276165519374 0.267565072076763 no 2509 0.251659663959607 3583 24207270 SGTC_93 0109-0045 59.227 µM -0.671499169904853 0.2668957254367 no 2510 0.250951294050563 3689 88733 SGTC_477 mead ethanolamide 10 µM -0.672681947934761 0.266539936056645 no 2511 0.250574827278588 3514 16061185 SGTC_2345 9052315 157.45 µM -0.674490759476595 0.265996294930806 no 2512 0.249999679274407 3635 6469265 SGTC_783 0848-0141 92.7 µM -0.675064367152636 0.265824013630336 no 2513 0.249817435583815 3626 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_990 3985-0011 41.3 µM -0.67610449924593 0.265511757476018 no 2514 0.249487150135338 3612 5399565 YGL099W LSG1 SGTC_2019 4016004 108 µM -0.676405567737357 0.265421408992844 no 2515 0.249391591617246 3607 45595336 SGTC_1872 amphotericin b 148 nM -0.677460706183542 0.265104892748886 no 2516 0.249056846475421 3650 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_401 neomycin 50 µM -0.677530097810341 0.265084083644799 no 2517 0.249034840199854 3607 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_363 0455-0021 3.06 µM -0.678131307605943 0.264903828086471 no 2518 0.248844220912478 3663 4597466 SGTC_46 0329-0187a 2.197 µM -0.678390187997563 0.264826229398965 no 2519 0.248762164350401 3649 46494817 SGTC_3062 9077494 49.47 µM -0.678396565835772 0.264824317805309 no 2520 0.248760142967501 3609 16459633 SGTC_2657 nystatin 74.44 µM -0.678457738375757 0.264805983259484 no 2521 0.248740755474604 3652 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3212 9128307 49.47 µM -0.679939750774558 0.264361993918964 no 2522 0.24827130532177 3600 27243542 SGTC_897 1000-0139 31.4 µM -0.681450665754556 0.263909736224829 no 2523 0.247793186575027 3622 6151020 SGTC_2712 st079126 47.7 µM -0.683769652036711 0.263216368970996 no 2524 0.24706031648589 3632 3152970 SGTC_187 1488-2104 32.728 µM -0.685287426567797 0.26276306504986 no 2525 0.246581282200481 3681 2852859 SGTC_3060 1327-0027 12.5 µM -0.686943176428536 0.262269008738154 no 2526 0.246059268634443 3585 16000455 YPR107C YTH1 SGTC_3326 9140064 16.379 µM -0.687049746078471 0.262237225913265 no 2527 0.246025690397099 3636 1868434 SGTC_1186 1319-0216 26 µM -0.687706029567556 0.262041542550715 no 2528 0.245818961115164 3701 4565136 SGTC_2474 5321570 43.32 µM -0.688071585251327 0.261932577660438 no 2529 0.245703851531583 3671 2841384 SGTC_3213 9129884 49.47 µM -0.689094567452247 0.261627770510595 no 2530 0.24538187924213 3605 17190742 SGTC_2324 6149169 200 µM -0.690316833722947 0.261263823637182 no 2531 0.24499748201218 3601 2888231 SGTC_470 aa-861 153 µM -0.69228861791005 0.26067724608986 no 2532 0.244378048268887 3645 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2928 9011484 9.79 µM -0.693045938726199 0.260452134285591 no 2533 0.244140361326855 3667 2994751 SGTC_625 k213-0058 121 µM -0.694187191602877 0.260113088805182 no 2534 0.243782412003522 3725 3655420 SGTC_385 1494-0393 12.4 µM -0.694684453460154 0.259965432545752 no 2535 0.243626536494619 3684 3090647 SGTC_1809 st050081 57.6 µM -0.694842671820586 0.25991846046804 no 2536 0.243576951445005 3719 5036894 SGTC_3165 9101544 49.47 µM -0.696143407794063 0.259532462240805 no 2537 0.243169512267906 3661 5002184 SGTC_2624 nerol 100 µM -0.697586730030612 0.259104497738415 no 2538 0.242717841373907 3619 637566 A natural product oil. SGTC_3299 9121982 43.1275 µM -0.698140265619079 0.258940463827983 no 2539 0.242544739415358 3697 17594604 YPL160W CDC60 SGTC_1970 st070122 35.8 µM -0.699204826072187 0.258625144637719 no 2540 0.242212017499918 3699 102928 SGTC_129 0088-0017 176.636 µM -0.701388588662691 0.257978944319193 no 2541 0.241530270750757 3596 182446 SGTC_1092 toremifene 6.32 µM -0.701587691817967 0.257920069108969 no 2542 0.241468164805627 3678 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_2032 5185112 25.99 µM -0.701885493384724 0.257832021589367 no 2543 0.241375288206257 3606 5718189 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -0.703012909164728 0.257498833060738 no 2544 0.241023852292611 3704 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_1320 1313-0481 95.3 µM -0.70383446133719 0.257256178260707 no 2545 0.240767934964223 3698 6813365 YLR208W SEC13 SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.705446832426169 0.256780291868557 no 2546 0.240266104023103 3649 688662 SGTC_3216 9129716 49.47 µM -0.706859877586949 0.256363612991501 no 2547 0.239826779888703 3668 8056934 SGTC_3125 9127534 49.47 µM -0.707134381440537 0.256282708167505 no 2548 0.239741485873176 3562 1639235 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.70716141348577 0.256274741702881 no 2549 0.239733087353889 3751 6728940 SGTC_1548 st061468 90.8 µM -0.707183914589141 0.256268110625535 no 2550 0.239726096664159 3684 390799 SGTC_313 3474-0040 5.03 µM -0.708457486483247 0.255892934717402 no 2551 0.23933060207433 3669 1043375 YIL048W NEO1 SGTC_2638 epoxomicin 18 µM -0.709113403722701 0.255699822847034 no 2552 0.239127052888335 3700 9915668 A protesome inhibitor. SGTC_383 2324-0395 7.37 µM -0.709531589991729 0.25557674227388 no 2553 0.238997327578474 3705 3146421 SGTC_1313 1220-0047 237 µM -0.710772330320834 0.255211749800659 no 2554 0.238612664799465 3706 3528706 SGTC_3047 9092122 49.47 µM -0.710821545581344 0.255197277615158 no 2555 0.238597413738508 3665 17173831 SGTC_2214 7179297 48.276 µM -0.711152771146873 0.255099888952641 no 2556 0.238494785850885 3714 769744 SGTC_3076 9116187 49.47 µM -0.711228124290916 0.255077735944101 no 2557 0.238471441589466 3664 27241210 SGTC_2151 5563267 85.4165 µM -0.711980727186219 0.254856534068903 no 2558 0.238238355294187 3717 5310824 SGTC_1948 st076329 66.6 µM -0.712635445675717 0.25466418366259 no 2559 0.238035686030143 3608 24208413 SGTC_3093 9117344 49.47 µM -0.714068445557213 0.25424344663751 no 2560 0.237592428350418 3716 24824913 SGTC_2409 alverine citrate 63.97 µM -0.714738472034422 0.254046848121363 no 2561 0.237385330262338 3829 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1579 chlormadinone acetate 49.4 µM -0.714783658264555 0.254033592493001 no 2562 0.237371367245582 3697 45114258 A steroidal progestin. SGTC_1384 3089-0840 101 µM -0.716501236422859 0.253530000685886 no 2563 0.236840952159828 3668 1069836 SGTC_2436 5633522 8.09 µM -0.716916776152352 0.25340824379279 no 2564 0.236712724946849 3680 5724242 SGTC_3018 9082602 49.47 µM -0.717564011931386 0.253218659094887 no 2565 0.236513077067038 3698 17332089 SGTC_1421 4029-0249 71.4 µM -0.719204323078762 0.252738522532735 no 2566 0.236007518074347 3775 2894095 SGTC_2948 9070189 9.45 µM -0.719919242337675 0.252529408144495 no 2567 0.235787359850165 3613 6473636 YDL196W YDL196W SGTC_1140 3229-1848 2.98 µM -0.720009214929142 0.252503097557646 no 2568 0.23575966096111 3727 2849525 SGTC_1399 3562-5772 25 µM -0.720538367957833 0.252348387147226 no 2569 0.235596792650635 3660 23847490 SGTC_2974 9094440 9.66 µM -0.720857831751235 0.2522550085434 no 2570 0.2354984947634 3788 25236134 SGTC_2372 9071633 200 µM -0.721567061287301 0.252047767363803 no 2571 0.235280348236099 3748 21321366 SGTC_1988 st071872 53.4 µM -0.721631013621031 0.252029084519497 no 2572 0.235260683108359 3711 16414116 SGTC_1744 st037937 38.9 µM -0.7216741654322 0.252016478690761 no 2573 0.235247414584181 3749 1016152 SGTC_1568 digitonin 820 nM -0.721774336777317 0.251987217173309 no 2574 0.235216615015373 3707 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_2788 5282734 71.43 µM -0.721870771857573 0.251959048767428 no 2575 0.23518696633537 3756 743706 SGTC_2696 st077691 74.316 µM -0.722464200304355 0.251785746629478 no 2576 0.235004563948013 3705 757133 SGTC_1098 clofazimine 15.1 µM -0.723125615445682 0.251592664157201 no 2577 0.234801356592835 3758 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_86 0417-1630 471.922 µM -0.723790666836087 0.251398599073 no 2578 0.234597130039439 3743 3634867 SGTC_969 1313-0238 134 µM -0.724685987493036 0.251137465356232 no 2579 0.234322346734865 3733 5212874 SGTC_1266 0828-0227 32.9 µM -0.726568351214292 0.250588913972776 no 2580 0.233745210950467 3730 3913820 SGTC_1004 4084-0029 199 µM -0.728151379935489 0.250128085510144 no 2581 0.233260462336989 3734 716894 YLR208W SEC13 SGTC_1756 st041558 35.5 µM -0.728244503318332 0.250100990782294 no 2582 0.233231963859722 3775 3955792 SGTC_1032 k061-1018 98.7 µM -0.730801336668979 0.249357675586608 no 2583 0.232450253495769 3833 4005393 SGTC_3067 9117431 49.47 µM -0.730966972376801 0.249309562988103 no 2584 0.232399663366261 3751 17150885 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.731149574671303 0.249256527784924 no 2585 0.23234389822864 3687 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_20 0481-0013 4.944 µM -0.731679384036964 0.249102683353643 no 2586 0.232182141238934 3724 182045 SGTC_753 1322-0200 289 µM -0.732934125813379 0.24873853681811 no 2587 0.231799304006114 3748 5403907 SGTC_1074 carmofur 3.8 µM -0.735302862738687 0.248051864121987 no 2588 0.231077532564192 3761 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2756 carbadox 75.1 µM -0.735430607470274 0.248014860988878 no 2589 0.231038643490192 3745 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_172 1112-0046 2.638 µM -0.73830898401049 0.247181878455699 no 2590 0.230163354178216 3696 2802135 YIL048W NEO1 SGTC_3104 9120930 49.47 µM -0.738717247457021 0.247063851073813 no 2591 0.230039355200556 3754 17014836 SGTC_1959 st077091 55.8 µM -0.739532040355848 0.246828387756881 no 2592 0.229791995685799 3746 821356 YKL052C ASK1 SGTC_1312 1218-2183 165 µM -0.740075391424118 0.246671433977161 no 2593 0.229627124852673 3748 6744073 SGTC_2801 7907800 81.82 µM -0.741143699540975 0.246362995681054 no 2594 0.229303157848142 3798 6620925 SGTC_1187 1391-0724 117 µM -0.741278610924116 0.24632405923041 no 2595 0.229262263878125 3807 6997986 SGTC_355 1311-2252 105 µM -0.743167851471438 0.245779156750553 no 2596 0.228690032201737 3748 5338538 SGTC_220 paclitaxel 373.376 µM -0.743587482244859 0.245658213018461 no 2597 0.228563039261091 3682 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1689 st020265 53.493 µM -0.744044239365525 0.24552660526564 no 2598 0.228424855799991 3740 5758320 YPR016C TIF6 SGTC_1386 3228-0095 33.8 µM -0.744251567670827 0.245466879207406 no 2599 0.228362147929392 3732 870181 SGTC_2196 6573537 42.6665 µM -0.745940221779645 0.24498071138419 no 2600 0.227851763322281 3762 2903087 SGTC_1492 4158-0558 28.5 µM -0.746673803501262 0.244769672858881 no 2601 0.227630243210621 3762 3967268 SGTC_66 0109-0187 42.4 µM -0.751240964561481 0.243457985359167 no 2602 0.226253825443419 3746 759417 SGTC_2692 st077426 47.7 µM -0.751658239865564 0.24333833361344 no 2603 0.226128304902618 3742 25238571 SGTC_1741 st038134 10.228 µM -0.752325220226982 0.243147146122499 no 2604 0.225927752358058 3802 1272587 SGTC_938 3126-1755 342 µM -0.753770189808325 0.242733229586251 no 2605 0.225493613446558 3766 1777771 SGTC_2001 4023502 57.655 µM -0.754613058473026 0.242491963185723 no 2606 0.225240593050629 3786 108941 YCR052W RSC6 SGTC_2861 9024595 19.48 µM -0.755707424281566 0.242178901058814 no 2607 0.224912315889683 3674 16482810 SGTC_1502 4534-4282 27.7 µM -0.757028810023175 0.241801188168175 no 2608 0.224516301186224 3734 3278949 SGTC_492 tmb-8 126 µM -0.759201363120864 0.241180867966361 no 2609 0.223866055390562 3666 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.762116136526268 0.240349985226809 no 2610 0.222995346399046 3774 616764 SGTC_2982 9019404 25.97 µM -0.762187276950089 0.240329725512989 no 2611 0.222974119279698 3696 22333232 SGTC_2498 4'-Methoxychalcone 54.63 µM -0.764157379554454 0.239769039977119 no 2612 0.222386730861346 3775 641818 YHR062C RPP1 SGTC_2356 9061756 188.97 µM -0.764733750556123 0.239605141493067 no 2613 0.22221505219621 3789 20104043 SGTC_1390 3413-2614 145 µM -0.765452076772097 0.239400961855589 no 2614 0.222001196455201 3830 3421432 SGTC_3306 9127676 59.7925 µM -0.765789024582868 0.239305219344211 no 2615 0.22190092288977 3785 41905287 SGTC_1450 4112-4260 37.6 µM -0.766029071697216 0.239237023579077 no 2616 0.221829502146821 3752 1633175 SGTC_2284 7945075 39.21 µM -0.766173042303937 0.239196127595954 no 2617 0.221786673156792 3854 1245402 SGTC_1686 st019653 115.5 µM -0.766492361923048 0.239105435980993 no 2618 0.221691697453711 3759 97252 SGTC_2991 9074669 71.4286 µM -0.769452704894461 0.238265549123361 no 2619 0.220812305400331 3749 17333109 SGTC_2847 9005661 71.43 µM -0.76945767737256 0.238264139729106 no 2620 0.22081082997081 3737 2991449 SGTC_70 0141-0289 43.283 µM -0.772497496421493 0.237403391755495 no 2621 0.21990991456846 3816 352408 SGTC_1735 st034310 56.75 µM -0.773107327566317 0.237230919244539 no 2622 0.219729432436016 3927 871153 SGTC_833 3852-0053 558 µM -0.775086715150308 0.236671583164745 no 2623 0.219144210544552 3853 3123681 SGTC_2184 6075246 200 µM -0.776266358817397 0.236338584329921 no 2624 0.218795865988516 3846 2267320 SGTC_873 0591-4978 488 µM -0.778054816493031 0.235834217208596 no 2625 0.218268349027613 3820 3305145 SGTC_265 mycophenolic acid 32.932 µM -0.778720076269246 0.235646757273776 no 2626 0.218072313568543 3867 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_1772 st048439 82.2 µM -0.780319826238504 0.235196309060344 no 2627 0.217601322856316 3830 2927068 YDL195W SEC31 SGTC_3200 9114385 49.47 µM -0.780654965285689 0.235102002848896 no 2628 0.217502727251035 3822 17018030 YLR208W SEC13 SGTC_1031 k035-0009 16 µM -0.780740418427323 0.23507796016566 no 2629 0.217477591650273 3886 5180959 SGTC_2164 5685496 200 µM -0.780841204886455 0.235049605119924 no 2630 0.217447947988528 3744 759046 SGTC_2946 9065502 71.43 µM -0.780853374522289 0.235046181468588 no 2631 0.217444368771013 3626 16489101 SGTC_761 k216-0224 480 µM -0.781128560410846 0.234968771508247 no 2632 0.217363442796038 3811 1340404 SGTC_3179 9107801 49.47 µM -0.782223748584664 0.234660834031091 no 2633 0.217041544991544 3801 4818259 SGTC_1520 flindersine 88 µM -0.782784826094159 0.234503160609237 no 2634 0.216876739812877 3926 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2876 9059903 25.97 µM -0.783801904265098 0.23421749182619 no 2635 0.216578178158296 3753 6916095 SGTC_2977 9011197 71.43 µM -0.785709981402296 0.233682086503102 no 2636 0.216018707131057 3871 2704722 SGTC_2521 angolensin 13.4 µM -0.786551832625222 0.233446079440685 no 2637 0.21577213271027 3868 821428 A flavenoid. SGTC_2420 aureobasidin a 50 nM -0.787348252231408 0.233222930576458 no 2638 0.21553901524659 3898 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_1540 guanosine 70.6 µM -0.788306321051162 0.232954646158175 no 2639 0.215258775591592 3713 6802 Guanosine is a purine nucleoside SGTC_3124 9127567 49.47 µM -0.789500089776999 0.232620599570618 no 2640 0.214909888660911 3750 17592030 SGTC_1793 st048256 72.231 µM -0.79159663052505 0.232034579619894 no 2641 0.214297956122005 3698 672022 SGTC_2606 farnesol 9.78 µM -0.791937244648103 0.231939449666424 no 2642 0.21419863440423 3832 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_858 0438-0351 2.77 µM -0.79291298970535 0.231667054564441 no 2643 0.213914259341776 3829 2799119 SGTC_1069 diphenylcyclopropenone 8.49 µM -0.793045720973241 0.231630014252026 no 2644 0.213875592598662 3872 65057 A dermal irritant. YDR527W RBA50 SGTC_1712 st032288 53.4 µM -0.793573572418789 0.231482743403496 no 2645 0.213721861301362 3782 2883011 SGTC_2920 7982904 15.77 µM -0.795335810577282 0.23099145623671 no 2646 0.213209093942025 3835 6456808 SGTC_446 go6976 132 µM -0.795659898850496 0.230901168400535 no 2647 0.213114870502898 3804 3501 A protein kinase C inhibitor. SGTC_466 geldanamycin 89.2 µM -0.796758488670493 0.230595258633959 no 2648 0.212795654000718 3701 5288382 HSP90 inhibitor. SGTC_987 1497-1013 404 µM -0.798488028482851 0.230114115823416 no 2649 0.212293668800395 3800 1676435 SGTC_1456 k015-0012 13 µM -0.798760065155923 0.230038488759437 no 2650 0.212214775353681 3853 2989616 SGTC_16 erodoxin 22.806 µM -0.798767457322346 0.230036433907685 no 2651 0.212212631788229 3852 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_328 k915-0120 63.5 µM -0.799457415500193 0.22984468667557 no 2652 0.21201261484071 3829 6624543 SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.800780651581926 0.229477194801998 no 2653 0.211629321039894 3667 6708630 An antioxidant. SGTC_2567 aureobasidin a 60 nM -0.801294159383111 0.229334671080694 no 2654 0.211480685655579 3991 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_3307 9126885 69.2785 µM -0.801590778572652 0.229252367253405 no 2655 0.211394856773061 3815 24824909 SGTC_1861 st057647 17.4 µM -0.802657407033579 0.228956543512943 no 2656 0.211086388837496 3902 688668 SGTC_658 3253-0951 102 µM -0.803310380585184 0.228775550518562 no 2657 0.210897679767072 3834 1184878 SGTC_505 gw-5074 63.9 µM -0.803628612265855 0.228687371310974 no 2658 0.210805746815643 3880 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_2347 9049783 174.81 µM -0.804820680505456 0.228357229352644 no 2659 0.210461582949531 3862 6467988 YPL169C MEX67 SGTC_2932 9016711 44.54 µM -0.804835969156641 0.228352996918226 no 2660 0.210457171082553 3838 7117328 SGTC_155 k072-0202 43.6 µM -0.805236767182618 0.228242057706894 no 2661 0.210341531615096 3760 5857737 SGTC_548 1436-0017 110 µM -0.805459973276884 0.228180288333962 no 2662 0.210277147689362 3906 9677137 SGTC_1628 st004252 77.7 µM -0.806490881502819 0.227895119921172 no 2663 0.209979931815754 3850 692968 SGTC_937 3122-0005 46.7 µM -0.806940950567392 0.227770685343825 no 2664 0.209850252159452 3886 759535 SGTC_1368 1852-0141 284 µM -0.807446068941557 0.22763107634896 no 2665 0.209704767072222 3839 2838987 SGTC_379 3970-0972 5.9 µM -0.807972506903525 0.22748562614598 no 2666 0.209553204613392 3835 2898042 YBL034C STU1 SGTC_1319 1306-0155 43.7 µM -0.808263071037141 0.227405368242103 no 2667 0.20946957826799 3883 3122360 SGTC_1980 st071811 45.7 µM -0.809668387680736 0.227017425215204 no 2668 0.209065395735829 3966 4974850 SGTC_2157 5649910 96.377 µM -0.810884582664182 0.226681991387374 no 2669 0.208715977407706 3812 2858091 SGTC_2220 6782180 200 µM -0.81107170236739 0.226630407497014 no 2670 0.20866224763746 3742 833803 SGTC_2741 miltefosine 3.04 µM -0.811209545571823 0.226592412055986 no 2671 0.2086226723943 3794 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_805 3852-0218 479 µM -0.812423560416998 0.226257933340153 no 2672 0.208274315822133 3793 6615355 SGTC_2781 5567276 71.43 µM -0.813250087355242 0.226030372857866 no 2673 0.208037343792465 3906 2853274 SGTC_1193 1488-0126 41.5 µM -0.814429409951072 0.225705904316658 no 2674 0.207699498066149 3847 1384710 SGTC_2260 7964312 200 µM -0.820574459194406 0.224019479094081 no 2675 0.2059443503977 3907 231951 SGTC_402 epigallocatechin gallate 10 µM -0.822092093907743 0.223604089852765 no 2676 0.205512242399782 3832 65064 An antioxidant. SGTC_1116 jasmonic acid  1.58368 µM -0.824497543407303 0.222946596524242 no 2677 0.204828455528699 3921 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_227 fluconazole 33.516 µM -0.825273555252082 0.222734720568812 no 2678 0.20460815092346 3862 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_3215 9129942 49.47 µM -0.826003274881521 0.222535588595848 no 2679 0.204401117042786 3824 17682944 SGTC_3101 9120531 49.47 µM -0.82612186780728 0.222503235562141 no 2680 0.204367481994819 3874 24824904 SGTC_2837 9008476 45.46 µM -0.826532028099502 0.222391361460704 no 2681 0.204251178699699 3847 2992805 SGTC_2583 asiatic acid 100 µM -0.826860027891697 0.222301920305585 no 2682 0.204158200850991 3850 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_1907 st060210 83.7 µM -0.827386055439603 0.222158522487835 no 2683 0.2040091408697 3913 688793 SGTC_2983 9022671 12.99 µM -0.828032699561527 0.2219823163298 no 2684 0.203825990747894 3909 6405161 SGTC_2852 9023854 51.95 µM -0.828473852020476 0.221862151066564 no 2685 0.203701098637541 3951 19798528 SGTC_3024 9090631 49.47 µM -0.829288506851478 0.221640345386442 no 2686 0.203470586399008 3811 25236383 SGTC_1975 st070967 30.8 µM -0.830172630199242 0.221399768997599 no 2687 0.203220593719604 3832 261391 SGTC_2693 st077581 40.7 µM -0.834182563069964 0.220310513256248 no 2688 0.202089057738195 3936 25238761 SGTC_2277 7947813 106.88 µM -0.835031619419127 0.220080270873375 no 2689 0.201849952803081 3978 1246798 SGTC_3342 9147791 14.508 µM -0.836251358293512 0.219749750559723 no 2690 0.201506755614234 3810 1838168 SGTC_2015 5119600 184 µM -0.837498518220724 0.219412094632739 no 2691 0.201156204754121 3922 2828786 SGTC_2700 st077718 96.8 µM -0.837543134492925 0.219400020754099 no 2692 0.201143670821959 3873 904970 SGTC_2182 6325192 200 µM -0.838157427393673 0.219233822062375 no 2693 0.200971146751277 3806 736248 SGTC_1079 idarubicin 2.36 µM -0.838270228755078 0.219203311199592 no 2694 0.200939476155765 3851 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3168 9103419 49.47 µM -0.840503016420808 0.218599882396228 no 2695 0.200313205514213 3848 16649256 SGTC_1238 0333-0287 48.8 µM -0.840777727200904 0.2185257057265 no 2696 0.200236233478448 3885 7226 SGTC_2313 7726885 200 µM -0.841249060611641 0.218398471311407 no 2697 0.200104210574574 3925 726423 SGTC_1856 st057054 55.7 µM -0.842657981156074 0.218018393814183 no 2698 0.199709876799354 3896 1266018 SGTC_1498 4478-3555 97.6 µM -0.842820153297033 0.217974669927013 no 2699 0.199664517497488 3841 3437919 SGTC_2621 lithochol-11-enic acid 100 µM -0.845041134441719 0.217376371176379 no 2700 0.199043936410543 3826 6708711 SGTC_2634 4'-methoxyflavone 100 µM -0.8458639595645 0.217154955475279 no 2701 0.198814319998085 3915 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_911 3456-4043 236 µM -0.846605764082292 0.216955453500994 no 2702 0.198607450014987 3957 914281 SGTC_3323 9138564 53.9225 µM -0.84772424904469 0.216654846919368 no 2703 0.198295779211326 3908 43912313 YNL103W MET4 SGTC_2648 atorvastatin 78.68 µM -0.84815095637081 0.216540227597814 no 2704 0.198176953152303 3899 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2422 chlorphenesin carbamate 384.24 µM -0.848869055328654 0.216347415789998 no 2705 0.197977079739613 3902 2724 A muscle relaxant with antifungal properties. SGTC_1200 1643-0193 18.4 µM -0.849615430646942 0.216147117054454 no 2706 0.197769465062457 3880 5403974 SGTC_2914 7968218 45.32 µM -0.850366358214106 0.215945705086444 no 2707 0.197560716933928 3881 2977111 SGTC_3090 9117696 49.47 µM -0.853351659128726 0.215146071152828 no 2708 0.196732160202606 3856 7923821 SGTC_261 5-fluorouridine 15.376 µM -0.85394445648966 0.214987490987237 no 2709 0.196567882783007 3902 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2572 astragaloside iv 100 µM -0.855514654451597 0.214567772998981 no 2710 0.196133147581566 3978 45006101 An anti-inflammatory agent. SGTC_3128 9127691 49.47 µM -0.855663220615851 0.214528085559206 no 2711 0.196092044805596 3956 41316314 SGTC_115 0527-0192 112.043 µM -0.856357061753487 0.214342791806447 no 2712 0.195900153747253 3941 4233931 SGTC_1984 st072354 53.1 µM -0.857691251816013 0.213986751369463 no 2713 0.195531485958726 3811 5762938 SGTC_2483 5729050 27.16 µM -0.858889551729079 0.213667268075386 no 2714 0.195200727182721 3896 2865180 SGTC_865 0488-0499 301 µM -0.859820450279532 0.213419269565598 no 2715 0.194944012251697 3892 9634651 SGTC_2328 6201408 200 µM -0.860050188464747 0.213358091375188 no 2716 0.194880688693656 3933 2890418 SGTC_3052 9092717 49.47 µM -0.860278864244902 0.213297206252383 no 2717 0.19481767039411 3920 25237534 SGTC_1939 st074455 53.6 µM -0.860430898310371 0.213256732659025 no 2718 0.194775779820994 3905 1644229 SGTC_2955 9076254 12.21 µM -0.860970866939755 0.213113021664543 no 2719 0.194627044329557 3870 16459619 SGTC_1622 st003707 19.4 µM -0.86098153118641 0.213110183976984 no 2720 0.194624107536552 3951 10140899 SGTC_1837 st055472 66.5 µM -0.864001443685377 0.212307491890744 no 2721 0.193793548740411 4025 676091 SGTC_1895 st058434 18.3 µM -0.864082485339128 0.212285975410011 no 2722 0.193771289872771 3940 5393175 SGTC_2341 7987486 176.74 µM -0.865134408965376 0.212006806358076 no 2723 0.193482510389338 3961 1258686 SGTC_2205 7238770 200 µM -0.865837240831376 0.211820402162127 no 2724 0.193289711754419 3979 279867 SGTC_1422 4031-0024 15.5 µM -0.866558548219885 0.211629197655884 no 2725 0.193091966927239 3875 782427 SGTC_2724 maprotiline 69.64 µM -0.868405030502289 0.211140191844849 no 2726 0.192586320965916 3849 4011 A tricyclic antidepressant. SGTC_2475 5812728 15.03 µM -0.868843142278363 0.211024263521494 no 2727 0.192466466090731 3899 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_1239 0337-0584 35.4 µM -0.8690414141452 0.210971811265456 no 2728 0.192412239560372 4009 914301 YML130C ERO1 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.869271591743651 0.210910928027722 no 2729 0.192349298664135 3980 23847180 SGTC_1090 efavirenz 20.7 µM -0.869428127782822 0.210869529272535 no 2730 0.192306501872289 3973 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_1739 st037196 92.5 µM -0.872397750967528 0.210085062395653 no 2731 0.191495713515778 3995 612214 SGTC_2131 toluylene red 5.2905 µM -0.873057311548011 0.209911063351336 no 2732 0.191315920079317 3937 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_2466 5983409 37.09 µM -0.874840184403786 0.209441146791417 no 2733 0.190830434524233 3954 2879657 SGTC_3 0833-0587 95.581 µM -0.874965640057722 0.209408103435521 no 2734 0.190796300787071 3858 5382644 SGTC_739 1486-1183 203 µM -0.875597099643952 0.209241831936123 no 2735 0.190624551347512 3913 4346692 SGTC_3287 9117173 37.0625 µM -0.875733967334557 0.209205803148242 no 2736 0.190587337493913 3898 2789709 SGTC_3238 9133470 49.47 µM -0.876331816446246 0.209048469319958 no 2737 0.190424836673571 3927 3534688 SGTC_882 0843-0131 351 µM -0.876752273073718 0.20893786098954 no 2738 0.190310603719981 3898 5425421 SGTC_1513 0337-0559 19 µM -0.877036888482612 0.208863007592828 no 2739 0.190233301069782 3915 775073 SGTC_3132 9126706 49.47 µM -0.878164989599164 0.208566474263154 no 2740 0.189927094229915 4021 850858 SGTC_1913 st060213 96.1 µM -0.880449936528914 0.207966612840253 no 2741 0.189307807309533 3994 688959 SGTC_525 k781-2675 26.7 µM -0.884894384230313 0.206802744803601 no 2742 0.188106798566062 3923 3651118 YDL195W SEC31 SGTC_1979 st071809 45.3 µM -0.884911557008253 0.206798255257412 no 2743 0.188102167161027 4044 4976333 SGTC_2997 9067075 71.4286 µM -0.88766317281428 0.206079635185136 no 2744 0.187360980619574 3978 27209819 SGTC_812 4251-0442 148 µM -0.88937637058095 0.205632960372737 no 2745 0.186900419905488 3944 5723007 SGTC_1411 3909-8223 150 µM -0.889952371602794 0.205482911247189 no 2746 0.186745730456524 3970 X1411 SGTC_1860 st056228 74.6 µM -0.891273343482541 0.205139041715735 no 2747 0.186391272819587 3949 688679 SGTC_1416 3966-0321 25.3 µM -0.891313705204423 0.205128540318432 no 2748 0.186380449086284 3980 582530 YLR208W SEC13 SGTC_2094 5332512 191.667 µM -0.891922755385298 0.204970115153202 no 2749 0.186217168421087 4000 755774 SGTC_1716 st033144 30.6155 µM -0.89199182529111 0.204952153392458 no 2750 0.186198657022498 3951 674617 SGTC_1882 5615643 20 µM -0.892263670837286 0.204881468529528 no 2751 0.186125810880957 3886 2253075 SGTC_2093 5331342 194.4 µM -0.894486181891205 0.204304118509912 no 2752 0.185530909891911 4043 33839 SGTC_2898 9056270 58.44 µM -0.894593379010943 0.204276296022337 no 2753 0.185502246231364 3897 19154699 SGTC_1254 0550-0035 264 µM -0.895323983143489 0.204086731390973 no 2754 0.185306961683907 4058 15121435 SGTC_2770 toltrazuril 17.5 µM -0.895981891167509 0.203916118400622 no 2755 0.185131217486892 3879 68591 Kills coccidiodes. SGTC_634 1611-4317 11.2 µM -0.898495766086123 0.203264987296926 no 2756 0.184460650709196 3959 2843522 SGTC_2675 theaflavin digallate 100 µM -0.898680174305381 0.203217271718204 no 2757 0.184411520054124 3922 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_2020 4017018 200 µM -0.899034560083083 0.20312559326204 no 2758 0.184317126265756 4065 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1249 0481-0015 10.2 µM -0.900004424588545 0.20287481873326 no 2759 0.184058948031355 3920 4227577 SGTC_3111 9122088 49.47 µM -0.903723705939366 0.201914852786933 no 2760 0.183070962842643 3831 16876704 SGTC_319 1348-1596 45.5 µM -0.905269074287428 0.201516786135146 no 2761 0.182661427927413 4076 5380505 SGTC_2744 captopril 92.04 µM -0.907114866044749 0.201041951082516 no 2762 0.182173028729874 3978 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.91028850531999 0.200227094260364 no 2763 0.181335189475423 3957 803109 SGTC_2742 clothiapine 36.27 µM -0.912226808667193 0.199730397356258 no 2764 0.180824667089491 3932 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2614 arthonioic acid 13.39 µM -0.91303832173796 0.199522664669471 no 2765 0.180611193556779 3885 6710684 SGTC_1710 st031758 61.5 µM -0.913084143488138 0.199510939009103 no 2766 0.1805991445777 4018 5394341 SGTC_1433 4060-0023 7.6 µM -0.913410894876054 0.199427336248914 no 2767 0.180513238846127 3993 3840627 SGTC_745 0469-0705 296 µM -0.914545379390575 0.199137230293701 no 2768 0.180215172203373 4071 3486736 SGTC_1141 3253-0389 52.6 µM -0.918419255294585 0.198148535668336 no 2769 0.17919970685458 3973 5402031 SGTC_2491 paeonol 100 µM -0.919062640483228 0.197984617683035 no 2770 0.179031404415503 3853 11092 Increases levels of cortical cytochrome oxidase. SGTC_815 1582-0027 36.9 µM -0.9196538732241 0.197834059031287 no 2771 0.178876832198548 4062 3128206 SGTC_3126 9127922 49.47 µM -0.919856522366142 0.197782469926421 no 2772 0.178823870828861 4052 45595682 SGTC_419 nsc-638432 893 µM -0.920501586891584 0.197618307708758 no 2773 0.178655352070516 3968 368090 SGTC_1295 1013-0063 9.78 µM -0.920539424202936 0.197608681064149 no 2774 0.178645470433827 4001 6826038 SGTC_221 trifluoperazine 10.304 µM -0.920623789731729 0.197587217637844 no 2775 0.178623438672459 3954 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2754 granisetron 64.02 µM -0.920666346863026 0.1975763912168 no 2776 0.178612325676452 3989 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1073 triclabendazole 3.09 µM -0.921647152796482 0.197326976176513 no 2777 0.178356327275899 4066 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.924393349519364 0.196629643075536 no 2778 0.177640778010013 4035 6708561 SGTC_2845 9003024 42.97 µM -0.92476748299024 0.196534756218435 no 2779 0.17754343415564 4085 2990173 SGTC_3269 9137823 49.47 µM -0.928953348635925 0.195475039459012 no 2780 0.176456631789091 3905 17682936 SGTC_1968 st069590 43.6 µM -0.929890628752922 0.195238228866865 no 2781 0.176213857773478 4010 6384066 SGTC_630 4356-0227 183 µM -0.930748414222424 0.195021656021397 no 2782 0.175991859792016 3978 779312 SGTC_1567 st069303 68.4 µM -0.932535220159931 0.194570994217361 no 2783 0.175529996878104 4084 5581319 SGTC_1725 st036284 20.55 µM -0.933404744176701 0.19435191541143 no 2784 0.175305515911195 4110 707914 SGTC_1555 citronellol 128 µM -0.935115880221445 0.193921229109488 no 2785 0.17486429174116 3959 8842 A terpine precursor. SGTC_1831 st055328 12 µM -0.938714000254858 0.193017495652836 no 2786 0.173938801698237 4019 1103068 SGTC_740 k014-0057 261 µM -0.938802297991792 0.19299535044547 no 2787 0.173916129430014 4017 4012779 SGTC_1830 st055982 50.3 µM -0.939904410095774 0.192719069608094 no 2788 0.173633297506531 3921 455313 An antimicrobial agent. SGTC_2121 5257820 149.641 µM -0.940677653975015 0.192525374799214 no 2789 0.173435036902482 4067 791256 SGTC_2172 5754775 163.918 µM -0.941053832306995 0.192431186526509 no 2790 0.173338636477422 3987 2263357 SGTC_2403 6032726 181.2 µM -0.945266338751773 0.191378376088386 no 2791 0.172261459469684 4087 2881040 SGTC_683 panaxydol 45 µM -0.950192826728838 0.19015161169427 no 2792 0.17100714141879 4013 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_141 0443-0274 32.331 µM -0.950445080900352 0.190088927194848 no 2793 0.17094307338121 4060 1627241 SGTC_229 benomyl 22.8748 µM -0.951502196645438 0.189826374853892 no 2794 0.170674751981458 4049 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_2857 9024691 58.44 µM -0.952738672462792 0.189519558548369 no 2795 0.170361246975056 4141 16478292 SGTC_1126 isoteolin 1.0172 µM -0.952749069643788 0.189516979909828 no 2796 0.170358612363547 3974 133323 SGTC_3133 9127736 49.47 µM -0.953599871961659 0.189306042839612 no 2797 0.170143110299853 3995 27243420 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -0.955235651535104 0.188900894786868 no 2798 0.169729270228579 4003 688761 SGTC_2669 eugenol 100 µM -0.955659673917996 0.188795960652991 no 2799 0.169622101168136 4027 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_2944 9067346 25.62 µM -0.957424921082743 0.188359495660118 no 2800 0.169176412404717 4004 6473075 SGTC_930 2810-3379 265 µM -0.957895590257699 0.188243225859015 no 2801 0.169057705159004 4077 1015764 SGTC_2537 larixol 68.93 µM -0.959125342229574 0.187939648261704 no 2802 0.168747802549919 4033 6708759 SGTC_859 0439-0102 54.6 µM -0.960020036796627 0.187718973283085 no 2803 0.168522565368847 4052 610143 SGTC_3042 9091578 49.47 µM -0.960097552412239 0.187699861718129 no 2804 0.168503060103828 4020 25236497 SGTC_2291 7917025 104.35 µM -0.961202893312318 0.187427469421021 no 2805 0.168225080953862 3972 2964612 SGTC_246 cycloheximide 667 µM -0.961932538996957 0.187247794709658 no 2806 0.168041746100323 3927 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2065 5221596 34.26 µM -0.966453121607898 0.186136980103712 no 2807 0.166908746780551 4039 788581 SGTC_1025 k007-0731 70 µM -0.967644873571084 0.185844820005197 no 2808 0.166610879112037 4015 6256118 SGTC_1418 3966-3099 2.4 µM -0.967843477996613 0.185796159441357 no 2809 0.166561273096528 4051 740335 SGTC_2368 9071271 200 µM -0.969952633292164 0.185279877779928 no 2810 0.166035051428126 4054 27209959 SGTC_2918 7977171 22.06 µM -0.970183239620414 0.185223483749537 no 2811 0.165977581741712 4011 2236483 SGTC_3116 9124943 49.47 µM -0.970467806254168 0.185153908595941 no 2812 0.165906682261937 4039 41905195 YPL160W CDC60 SGTC_257 daunorubicin 18.5 µM -0.971642764973887 0.184866808833489 no 2813 0.165614149819902 4078 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1683 st010134 710 nM -0.973229728545201 0.184479475656314 no 2814 0.165219569349623 4049 3818134 SGTC_1089 terbinafine 2.25 µM -0.975176934329013 0.184004907716872 no 2815 0.164736250738852 4066 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_1341 1486-1360 280 µM -0.975364398603801 0.183959259557073 no 2816 0.164689768358525 4038 3976547 SGTC_1468 k284-1086 134 µM -0.976663527530748 0.183643111237858 no 2817 0.164367878607731 4040 15996457 SGTC_1648 st011736 69.8 µM -0.976751925467202 0.183621611548754 no 2818 0.164345990770578 4074 2855514 SGTC_802 4112-3352 742 µM -0.978415073152964 0.183217401765759 no 2819 0.163934538100813 4124 704594 SGTC_1559 coumarin 343 70.1 µM -0.978791972476821 0.183125877711124 no 2820 0.163841388468906 4101 108770 A hepatotoxic, DNA x-linker. SGTC_237 nikkomycin 200 µM -0.978859739222089 0.183109424651605 no 2821 0.163824643748137 4084 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_888 0916-0002 6.97 µM -0.980152087619158 0.18279583242736 no 2822 0.163505525457235 4117 2802138 YIL048W NEO1 SGTC_1973 st070275 50.2 µM -0.980831519385376 0.182631100804189 no 2823 0.163337916071279 4019 17118334 SGTC_375 3970-0961 9.27 µM -0.981867130474462 0.182380190124763 no 2824 0.163082655423295 4022 2898222 SGTC_2425 5628681 7.85 µM -0.983124541570148 0.182075830791017 no 2825 0.162773073537736 4141 5714958 SGTC_1427 4048-4900 550 nM -0.983125538178116 0.182075589685708 no 2826 0.162772828318776 4059 24132586 SGTC_1207 2099-0101 141 µM -0.983132303013353 0.182073953101926 no 2827 0.162771163813187 4087 5837381 SGTC_2303 7774051 200 µM -0.983971647783097 0.181870965856276 no 2828 0.162564726711618 4101 2953184 SGTC_2786 7743617 45.45 µM -0.984492570501282 0.181745057050515 no 2829 0.162436691317629 4023 583674 SGTC_592 k241-0073 46.5 µM -0.985941202504379 0.18139520450896 no 2830 0.1620809832885 4085 4230158 SGTC_2715 st079500 56.4 µM -0.987248082309509 0.181079947922317 no 2831 0.161760517759206 4028 28246688 SGTC_2307 7538926 6.34 µM -0.987390145580707 0.181045698916862 no 2832 0.161725706722592 4072 96582 SGTC_702 1488-0190 94 µM -0.990687943855718 0.180251797525188 no 2833 0.160918989923391 4130 949357 SGTC_3278 9139605 49.47 µM -0.994322751385632 0.179379300946258 no 2834 0.16003288136856 4116 7958859 SGTC_374 0880-0231 82.3 µM -0.998510372020013 0.178377405316729 no 2835 0.159015968758432 4003 6833587 SGTC_2207 7258803 200 µM -0.99988058967511 0.178050345363168 no 2836 0.158684149459395 4052 3666799 SGTC_1300 1094-0077 113 µM -1.00011361677782 0.177994761305011 no 2837 0.158627763559183 4066 5532636 SGTC_2085 5307070 144.047 µM -1.00138437705239 0.177691838850173 no 2838 0.158320507081434 4018 2840351 SGTC_3058 9093861 49.47 µM -1.00175394822394 0.177603801966649 no 2839 0.15823122200018 4097 17217477 SGTC_1758 st042942 75.2445 µM -1.0045024242607 0.176949941366252 no 2840 0.157568251656721 4030 669317 SGTC_3335 9143315 29.6265 µM -1.00532046354046 0.176755624501359 no 2841 0.157371282270505 4107 4899691 SGTC_1275 0867-0008 21.1 µM -1.00629795701174 0.176523607901834 no 2842 0.157136131473823 4062 3422836 SGTC_777 1315-0167 517 µM -1.00667750728357 0.176433570276897 no 2843 0.157044887244877 4109 4221767 SGTC_2029 5175081 200 µM -1.00773351953956 0.17618321397054 no 2844 0.156791204344191 4069 1380876 SGTC_3197 9113331 49.47 µM -1.01069450378085 0.17548243230251 no 2845 0.156081334227622 4135 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_82 0054-0107 293.755 µM -1.01099592702815 0.175411193116169 no 2846 0.15600918959746 4043 3104697 SGTC_2569 tetrandrine 100 µM -1.01270864649524 0.175006752486479 no 2847 0.155599673315748 4122 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2493 resveratrol 26.09 µM -1.01348659542486 0.174823243614622 no 2848 0.155413897816481 4006 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_208 k072-0098 12.366 µM -1.01415955722704 0.174664598513204 no 2849 0.155253311527719 4074 5948901 SGTC_710 3448-4187 58 µM -1.0149573858369 0.174476635567898 no 2850 0.155063070692884 4072 3946412 SGTC_151 3013-0144 2.285 µM -1.01502159476425 0.174461513973245 no 2851 0.15504776688176 3996 906558 YHR107C CDC12 SGTC_2041 5107442 45.335 µM -1.0153491317916 0.174384389956805 no 2852 0.154969715924208 4155 793005 SGTC_1161 k007-0610 110 µM -1.01545734159172 0.174358914928261 no 2853 0.154943935600946 4076 5843850 SGTC_511 blebbistatin 171 µM -1.01657383447603 0.174096205374095 no 2854 0.154678103388638 4167 3476986 A myosin inhibitor. SGTC_1898 st060199 18.6 µM -1.01800901178614 0.173758879521994 no 2855 0.154336836706186 4076 688866 SGTC_362 0310-0100 9.03 µM -1.0191681943509 0.173486727540963 no 2856 0.154061561747509 4187 790235 SGTC_2860 9025725 38.96 µM -1.02161703832403 0.172912682363005 no 2857 0.153481095139986 4138 40546248 SGTC_513 4245-1575 41.7 µM -1.02354297409659 0.172462065854226 no 2858 0.153025596020546 4023 719745 SGTC_2965 9082772 38.63 µM -1.02389237177858 0.17238039664947 no 2859 0.152943056823723 4127 16459634 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -1.03148232676503 0.170612390369581 no 2860 0.15115734588958 3999 17037758 SGTC_2288 7946289 167.31 µM -1.03179940768369 0.170538782955201 no 2861 0.151083048409711 4192 1246052 SGTC_3277 9138724 49.47 µM -1.03205677241995 0.170479053054901 no 2862 0.151022761321109 4078 15943418 SGTC_826 1683-5028 118 µM -1.03241831751928 0.17039516732732 no 2863 0.150938097270255 4171 722377 SGTC_2721 ifenprodil 61.44 µM -1.03334197587916 0.170180980097207 no 2864 0.15072194501748 4127 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2750 bromebric acid 70.15 µM -1.03377879918646 0.170079745209172 no 2865 0.150619792525915 4175 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_3071 9117417 49.47 µM -1.03678654891772 0.169383739818851 no 2866 0.149917672850824 4084 45595590 YGL055W OLE1 SGTC_916 4466-0038 42 nM -1.03950706833685 0.168755777459283 no 2867 0.149284486231081 4203 5722064 YGL116W CDC20 SGTC_1832 st054113 55 µM -1.04078946598066 0.168460288235677 no 2868 0.148986635032691 4134 1251267 SGTC_3311 9131146 2.8755 µM -1.04154369800795 0.16828665405679 no 2869 0.148811641749358 4111 4900406 YPR165W RHO1 SGTC_2353 9059630 146.67 µM -1.04716723236054 0.166995672811566 no 2870 0.147511227623556 4180 4779114 SGTC_1590 st077108 57.8 µM -1.04731614673352 0.166961573927629 no 2871 0.147476895709811 4164 5489485 SGTC_1749 st037932 54.2 µM -1.04915076359534 0.166541846051048 no 2872 0.147054367701514 4179 594497 SGTC_1359 1582-0056 520 nM -1.0494222027217 0.166479803472189 no 2873 0.146991921943562 4198 3661189 SGTC_1876 myriocin 605 nM -1.0505143643119 0.166230319975309 no 2874 0.146740845136784 4140 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_1462 k081-0014 26.5 µM -1.05129098657314 0.166053062410512 no 2875 0.146562482754783 3706 3270634 SGTC_1147 3809-1045 12.3 µM -1.05245119881872 0.165788481221877 no 2876 0.146296294625264 4129 325925 SGTC_2421 5690543 90.72 µM -1.05259066948138 0.165756693924008 no 2877 0.146264317667163 4158 3397993 SGTC_3284 9108171 64.8615 µM -1.05270313432669 0.165731064496279 no 2878 0.146238535852034 4132 8687505 SGTC_2255 7941087 197.44 µM -1.05287662915525 0.165691532071776 no 2879 0.146198769306601 4248 935561 SGTC_2591 skatole 100 µM -1.05340276736666 0.165571683829541 no 2880 0.146078218198868 4173 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1317 1273-0028 910 nM -1.0535002774157 0.165549478320017 no 2881 0.146055883603199 4135 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_2936 9038235 15.59 µM -1.05490404897851 0.165230017434671 no 2882 0.145734605137235 4085 4749415 SGTC_1654 st012436 41.8 µM -1.05526353255405 0.1651482727916 no 2883 0.145652407294814 4125 4323132 SGTC_1746 st038117 42 µM -1.05859662475472 0.164391592312501 no 2884 0.144891762364222 4199 2898218 SGTC_1997 st073024 93.8 µM -1.06209381072413 0.163600079350285 no 2885 0.144096549800147 4157 686268 SGTC_1891 st059073 26.2 µM -1.06293389022021 0.163410314601412 no 2886 0.143905966350429 4235 688754 SGTC_2684 capsaicin 100 µM -1.06356164857998 0.163268604245399 no 2887 0.143763661886513 4164 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1291 0993-0025 5.79 µM -1.06611463209043 0.162693115924492 no 2888 0.143185912995923 4165 4353356 SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.06693110137353 0.162509347894482 no 2889 0.143001474648104 4199 94937 An inhibitor of serotonin biosynthesis. SGTC_1122 capsaicin 818.572 nM -1.06794422604341 0.162281505225001 no 2890 0.142772835621589 4220 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_951 1171-0579 82.7 µM -1.06891698874165 0.16206293539359 no 2891 0.142553538033594 4116 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2132 5317594 122.667 µM -1.06896853709927 0.162051358356388 no 2892 0.142541923438539 4119 794577 SGTC_1022 4477-0945 21.3 µM -1.07241257208558 0.161279096702505 no 2893 0.141767381791347 4116 4648966 SGTC_3345 9148410 3.559 µM -1.07788343359588 0.160057300131647 no 2894 0.140542889687879 4131 4903596 SGTC_2575 plumbagin 510 nM -1.07802155729198 0.160026531776621 no 2895 0.140512067947177 4083 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_1264 0783-0040 158 µM -1.08811571753174 0.157788432962084 no 2896 0.138272012928923 4060 2855798 SGTC_350 k064-0020 19.8 µM -1.08985995804407 0.157403789498496 no 2897 0.137887418734344 4216 2790705 SGTC_2545 solidagenone 89.61 µM -1.09007922335776 0.15735548030958 no 2898 0.137839123780138 4025 6708572 An anti ulcer agent SGTC_2812 7970281 58.44 µM -1.09126645700743 0.157094074719842 no 2899 0.13757782641952 4224 2233435 SGTC_3039 9090270 49.47 µM -1.09189104692057 0.156956666973668 no 2900 0.137440496709163 4196 17173750 SGTC_3271 9137798 49.47 µM -1.09194154054058 0.156945561997199 no 2901 0.137429398676416 4126 6498326 SGTC_2544 sphondin 68.51 µM -1.09379639129806 0.156537986057344 no 2902 0.137022143595348 4179 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_1511 0906-3109 28.5 µM -1.09412478433926 0.156465899234654 no 2903 0.13695012691446 4204 2882180 SGTC_284 0988-0104 32.6 µM -1.09486918194944 0.156302574594329 no 2904 0.136786976108557 4172 4666532 SGTC_286 k060-0067 22.9 µM -1.09581954207242 0.1560942239876 no 2905 0.136578877337424 4198 5985051 SGTC_863 0466-0191 129 µM -1.09686373666981 0.155865512847033 no 2906 0.1363504815285 4248 765160 YPR165W RHO1 SGTC_936 3005-4620 401 µM -1.09770809816947 0.155680733012386 no 2907 0.136165986226341 4259 777207 SGTC_390 dec-rvkr-cmk 16.7 µM -1.10062972132784 0.155042481034072 no 2908 0.135528922296261 4237 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_1058 3448-5425 97.3 µM -1.10063181686619 0.155042023867912 no 2909 0.135528466095403 4121 7279705 SGTC_2650 prasterone 100 µM -1.10425807691811 0.154252246372778 no 2910 0.13474060148431 4181 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_700 3453-2283 142 µM -1.1043002946878 0.154243067293772 no 2911 0.13473144752569 4250 565664 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -1.10924137844127 0.153171261311501 no 2912 0.133663033271577 4210 521171 SGTC_245 methotrexate 289.6 µM -1.11158369148989 0.152664901966667 no 2913 0.133158593866558 4187 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_2915 7971052 15.16 µM -1.11608558769986 0.151694807174472 no 2914 0.132192750345304 4114 5741558 SGTC_189 3970-0742 2.116 µM -1.11685263451408 0.151529928852625 no 2915 0.132028669761828 4146 2891807 SGTC_3254 9136651 49.47 µM -1.11759480220604 0.151370511798849 no 2916 0.131870044865631 4161 16454030 SGTC_1658 st012944 20 µM -1.12117723458523 0.150602577079402 no 2917 0.13110621402091 4068 24207260 SGTC_1323 1348-1351 11.2 µM -1.12148614954185 0.15053647941207 no 2918 0.131040491930287 4175 6989654 SGTC_2747 doxorubicin 7.63 µM -1.12163776515643 0.150504045714247 no 2919 0.13100824382401 4196 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_3176 9106582 49.47 µM -1.12696207618047 0.149368017976543 no 2920 0.129879257760552 4177 17018027 SGTC_2415 st077333 57.7 µM -1.1280779343341 0.149130659099175 no 2921 0.129643503538087 4274 2766255 SGTC_69 0096-0274 206.684 µM -1.1289226302147 0.148951147906396 no 2922 0.129465236669485 4348 6741392 SGTC_1637 st007924 17.4 µM -1.12960601603637 0.148806023332548 no 2923 0.12932113744674 4144 683336 SGTC_3064 1327-0027 10 µM -1.13021147309689 0.148677526769311 no 2924 0.129193563237283 4138 16000455 YPR107C YTH1 SGTC_107 0358-0022 2.6945 µM -1.13026039060741 0.148667148212241 no 2925 0.129183259772176 4238 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_1429 4049-0205 9.46 µM -1.13119967190075 0.148467960035192 no 2926 0.128985530006927 4235 22774478 SGTC_25 0118-0223 35.662 µM -1.13299817950557 0.148087058738652 no 2927 0.12860750890944 4234 5333628 SGTC_332 4112-0506 40.9 µM -1.13393332260552 0.147889265835063 no 2928 0.128411259030772 4184 2790355 SGTC_1245 0418-0076 17.2 µM -1.13611253362063 0.147429025667185 no 2929 0.127954735077255 4265 6790114 SGTC_3261 9137475 49.47 µM -1.14140305227583 0.146315687400678 no 2930 0.126851117552432 4176 17027690 SGTC_2476 5806916 10.51 µM -1.14331497442126 0.14591473432123 no 2931 0.126453919976437 4105 2870194 SGTC_737 1950-0117 57.9 µM -1.14557663536014 0.145441390947566 no 2932 0.125985184691951 4225 5393513 SGTC_1885 st057546 99.9 µM -1.14885688736688 0.144756703599834 no 2933 0.125307498735546 4262 702008 SGTC_3004 9076122 71.4286 µM -1.1500143978423 0.144515615305139 no 2934 0.125068970623776 4260 44782551 SGTC_2441 5730946 39.09 µM -1.15020745862442 0.144475430609384 no 2935 0.125029217478426 4287 1774275 SGTC_3262 9137218 49.47 µM -1.15055373058057 0.144403374591342 no 2936 0.124957938733244 4157 17650664 SGTC_934 2950-0684 338 µM -1.15184137498576 0.144135640106252 no 2937 0.124693131173612 4277 1121253 SGTC_2568 diosmetin 100 µM -1.15247096870031 0.144004853244853 no 2938 0.124563796390068 4289 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_1989 st071868 50.2 µM -1.15336364261202 0.143819553395577 no 2939 0.124380578944498 4236 16414057 SGTC_1556 plumbagin 1.48 µM -1.15425401161926 0.14363489230305 no 2940 0.124198022380512 4167 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_512 prima-1 270 µM -1.15463505212737 0.143555914033123 no 2941 0.12411995314481 4256 322968 A re-activator of the apoptotic function of mutant p53. SGTC_2440 5628896 157.78 µM -1.15567959682199 0.143339561582479 no 2942 0.123906118371304 4216 5522048 SGTC_2034 5197015 53.07 µM -1.15800670933324 0.142858347926412 no 2943 0.123430649214464 4261 780676 SGTC_289 k017-0060 526 µM -1.15860654952166 0.142734486738999 no 2944 0.123308298991145 4225 5512909 SGTC_1524 corynanthine 62.1 µM -1.15908548448145 0.142635643449588 no 2945 0.123210671001703 4349 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1924 st058459 75.1 µM -1.15921060099299 0.142609829349605 no 2946 0.123185175685168 4197 688683 SGTC_1315 1237-0019 3.69 µM -1.16000879574301 0.142445219783154 no 2947 0.123022612498862 4264 825140 SGTC_2748 diazoxide 86.69 µM -1.16023529547732 0.142398532767685 no 2948 0.122976510161115 4316 3019 A potassium channel activatior. SGTC_2884 9058502 51.95 µM -1.16241619703455 0.141949526456954 no 2949 0.122533223602503 4278 6471554 SGTC_1231 0242-0792 125 µM -1.1629113805417 0.141847711229885 no 2950 0.122432729771466 4244 3707635 SGTC_258 haloperidol 50.781 µM -1.16424294547627 0.141574172025937 no 2951 0.122162785440035 4258 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_872 0588-0139 234 µM -1.16605161942976 0.141203194565641 no 2952 0.121796787884686 4210 2047100 SGTC_1230 0170-0365 3.77 µM -1.16624059569548 0.141164471671013 no 2953 0.121758591742362 4304 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_1088 bifonazole 369 nM -1.16765315045559 0.140875254872544 no 2954 0.121473350802806 4227 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1602 st001878 87.6 µM -1.16908694381841 0.140582100895185 no 2955 0.121184301830857 4242 595405 YLR310C CDC25 SGTC_3162 9099653 49.47 µM -1.17055996680697 0.140281357529624 no 2956 0.120887848423255 4229 25237511 SGTC_2453 5731132 22.18 µM -1.17158849698023 0.140071624384338 no 2957 0.120681154286427 4300 1362040 SGTC_1143 3454-2408 5.08 µM -1.17652675369124 0.139067605706485 no 2958 0.119692223987442 4265 X1143 SGTC_851 0394-0702 453 µM -1.17877996282263 0.138611127348977 no 2959 0.119242902521129 4280 762646 SGTC_2851 9015922 71.43 µM -1.18189604907836 0.137981522160255 no 2960 0.118623474930981 4288 2996893 SGTC_182 3448-4371 550.524 µM -1.18487479445561 0.137381492906648 no 2961 0.118033477275516 4131 3491403 SGTC_628 1636-0253 16 µM -1.18507598816088 0.137341029403769 no 2962 0.117993701969007 4256 4456143 SGTC_627 1391-0720 175 µM -1.18651142697212 0.137052574231736 no 2963 0.117710195762189 4240 997839 SGTC_3021 9087658 49.47 µM -1.18866315933415 0.136620953812019 no 2964 0.117286121620257 4266 25237042 SGTC_2649 anisomycin 9.56 µM -1.18880603115253 0.136592327804391 no 2965 0.117258002090291 4315 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1332 1480-0653 17.5 µM -1.19061609900972 0.136230015094849 no 2966 0.11690216431912 4279 5749438 SGTC_2337 9009472 200 µM -1.1917853169951 0.135996328179157 no 2967 0.116672717255556 4258 5742383 SGTC_3065 9113888 49.47 µM -1.19188286883061 0.135976843295505 no 2968 0.116653588148639 4331 16648368 SGTC_884 0851-0618 334 µM -1.19531464512208 0.135292600611474 no 2969 0.115982059986517 4297 9642473 SGTC_506 n9-isopropylolomoucine 153 µM -1.1959908267437 0.135158059368285 no 2970 0.1158500694201 4291 6610355 SGTC_1596 piperlongumine 63 µM -1.19672272150319 0.13501253618666 no 2971 0.115707323903117 4324 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_1139 k015-0024 46.9 µM -1.19821567363226 0.134716024669135 no 2972 0.115416532552744 4300 2766652 SGTC_3069 9117009 49.47 µM -1.19932231087405 0.134496526776527 no 2973 0.115201321513441 4261 41904981 SGTC_2856 9022925 19.48 µM -1.20139717863038 0.134085645519542 no 2974 0.114798585019776 4325 4944862 SGTC_2953 9074162 66.49 µM -1.20253193226595 0.133861298040158 no 2975 0.114578750970649 4281 16451992 SGTC_3265 9137266 49.47 µM -1.2029183697525 0.133784955995697 no 2976 0.114503955473273 4248 17224265 SGTC_3329 9141233 27.5565 µM -1.2034876268062 0.133672551846691 no 2977 0.114393838318615 4256 4909101 YNL103W MET4 SGTC_3341 9147222 25.867 µM -1.20545898481107 0.133283794036313 no 2978 0.114013081273675 4294 1939759 SGTC_2063 5246145 200 µM -1.20978188485198 0.132434030270057 no 2979 0.113181299572372 4334 711240 SGTC_2010 4012422 159 µM -1.2098491642623 0.132420834552351 no 2980 0.11316838845288 4241 952393 SGTC_458 nppb 133 µM -1.2100495526511 0.132381537129724 no 2981 0.113129939549688 4347 4549 A chloride channel blocker. SGTC_1326 1431-2094 10.8 µM -1.21052627983323 0.132288080239596 no 2982 0.113038506461042 4269 616278 SGTC_2811 7967822 32.47 µM -1.21208969330827 0.131981910155822 no 2983 0.112739024306974 4337 2232244 SGTC_273 hydroxyurea 18.1 mM -1.21334421619367 0.131736585143977 no 2984 0.112499122212655 4360 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_762 1165-0429 115 µM -1.21687974515194 0.131046897411521 no 2985 0.111824986561227 4302 5967793 SGTC_2941 9056145 11.23 µM -1.21804215393926 0.130820688234245 no 2986 0.111603977084002 4225 2119517 SGTC_965 1291-5240 308 µM -1.22143796291676 0.130161397281533 no 2987 0.110960120443971 4311 2834598 SGTC_2641 levomentholum 100 µM -1.2214991885117 0.130149531567666 no 2988 0.110948536337275 4294 16666 SGTC_1182 1222-0449 220 µM -1.22236226684708 0.129982343905134 no 2989 0.110785330927772 4308 658318 SGTC_3289 9119912 71.43 µM -1.22809443040549 0.128875734099675 no 2990 0.109705760787504 4332 17014829 SGTC_3105 9121040 49.47 µM -1.22841760169401 0.128813540184748 no 2991 0.109645121830814 4212 41448907 SGTC_3313 9133968 57.047 µM -1.22966376055003 0.12857391340277 no 2992 0.109411521378806 4296 1494643 SGTC_3119 9125183 49.47 µM -1.23019295630208 0.128472246762908 no 2993 0.10931242845894 4143 22695334 SGTC_2002 4023503 131 µM -1.23117290066098 0.12828413175397 no 2994 0.109129102265197 4306 4736863 YCR052W RSC6 SGTC_1125 tnp00248 1.32998 µM -1.23598459357742 0.127363230786087 no 2995 0.108232145226692 4354 24207736 SGTC_2298 7976326 193.81 µM -1.2385990037283 0.126864796130993 no 2996 0.107747018616978 4233 2235818 SGTC_1688 st021091 57.6 µM -1.23862659305851 0.126859543503897 no 2997 0.107741907542019 4342 3656366 SGTC_2136 5328288 199.296 µM -1.24190629915316 0.126236211285715 no 2998 0.107135567853314 4306 262395 SGTC_3230 9131665 49.47 µM -1.2451823283644 0.125615712114688 no 2999 0.106532368440847 4300 15943720 SGTC_1906 st060206 94.7 µM -1.24595613276056 0.125469460243825 no 3000 0.10639025022034 4350 5133468 SGTC_386 1509-0011 3.07 µM -1.24596127820621 0.12546848813363 no 3001 0.106389305657535 4324 3107280 SGTC_2644 guaiazulene 100 µM -1.24855861644542 0.124978453426412 no 3002 0.105913278274315 4341 3515 A coloring agent. SGTC_2076 5212012 200 µM -1.24908036549922 0.124880177532898 no 3003 0.105817840625233 4295 604802 SGTC_2122 5258151 111.688 µM -1.24961729377841 0.124779098887533 no 3004 0.105719691328864 4330 2173356 SGTC_1878 temozolomide 1 mM -1.25358928122457 0.124033133938276 no 3005 0.104995664600647 4261 5394 DNA alkylating agent. SGTC_2840 9008771 71.43 µM -1.25630822446047 0.123524301429577 no 3006 0.104502120595038 4272 2992978 SGTC_1998 st075797 76.8 µM -1.25639672578313 0.123507763588563 no 3007 0.104486084081901 4315 24208315 SGTC_2995 9067767 71.4286 µM -1.25916175356786 0.122991856330689 no 3008 0.103985956461351 4339 11673567 SGTC_3073 9114972 49.47 µM -1.263341724364 0.122214816229159 no 3009 0.10323319871257 4332 41905075 SGTC_2080 5212524 12.4 µM -1.26533045463623 0.121846331596017 no 3010 0.102876446894786 4291 260183 SGTC_158 k038-0087 26.446 µM -1.26888313029077 0.121190013152486 no 3011 0.102241374958743 4247 X158 SGTC_2910 7948405 25.97 µM -1.27275634933763 0.120477315344975 no 3012 0.10155225753627 4288 2971328 SGTC_222 nsc-310342 10.666 µM -1.27376778952448 0.120291690710354 no 3013 0.101372861856768 4362 432556 SGTC_2886 9058944 51.95 µM -1.27448108964546 0.120160903461144 no 3014 0.101246485148446 4246 4949929 SGTC_2226 7298446 200 µM -1.27506419312538 0.120054062896212 no 3015 0.101143260930225 4358 3283010 SGTC_612 0302-0167 22.4 µM -1.2768090133272 0.119734763904636 no 3016 0.100834841318394 4352 235821 SGTC_2717 st081029 62.2815 µM -1.27758151128832 0.119593589581812 no 3017 0.100698511513932 4325 5292846 SGTC_557 1315-0110 16.2 µM -1.27869432506936 0.119390428854792 no 3018 0.100502359438157 4342 6833801 SGTC_2292 7671323 168.05 µM -1.27873674843215 0.119382688659963 no 3019 0.100494887129754 4393 937504 SGTC_1066 ketoconazole 628 nM -1.2801350555518 0.119127763957805 no 3020 0.100248820835438 4413 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2460 5552655 174.22 µM -1.28214250048625 0.118762459874236 no 3021 0.0998963311693576 4367 5401989 SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -1.28753656451172 0.117784799046976 no 3022 0.0989536667851709 4366 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3150 9097574 49.47 µM -1.28832987403121 0.117641495442381 no 3023 0.0988155790900097 4393 17217476 SGTC_1600 coumarin 106 71.1 µM -1.28945416069062 0.117438615508314 no 3024 0.0986201213449201 4411 100336 A hepatotoxic, DNA x-linker. SGTC_3107 9121808 49.47 µM -1.29047891666838 0.117253912027817 no 3025 0.0984422137202355 4303 662681 SGTC_2074 5212007 75.395 µM -1.29462319299413 0.116509040750023 no 3026 0.0977251237639852 4273 758611 SGTC_619 1652-1634 108 µM -1.3003175968769 0.115491040563925 no 3027 0.096746069690966 4345 5400454 SGTC_3068 9116768 49.47 µM -1.30197381215467 0.115196145574503 no 3028 0.0964626689904841 4333 41904888 SGTC_760 0568-0725 82.9 µM -1.30312148632899 0.114992112376766 no 3029 0.0962666446118915 4384 3916171 SGTC_315 k915-0449 187 µM -1.30456659886677 0.114735566395716 no 3030 0.0960202339842654 4395 20970215 YNL149C PGA2 SGTC_193 1273-0060 1.558 µM -1.30985702226459 0.113799850353648 no 3031 0.0951221042809861 4203 2847393 YHR072W ERG7 SGTC_3096 9117468 49.47 µM -1.31069168193436 0.113652722415118 no 3032 0.0949809750349078 4298 41316311 SGTC_2103 5378138 10 µM -1.31162204623878 0.113488884210699 no 3033 0.0948238453369058 4448 244142 SGTC_2973 9094665 17.96 µM -1.32368456927416 0.111379894327501 no 3034 0.0928039126515848 4379 25237061 YIL048W NEO1 SGTC_2379 9035213 200 µM -1.32402379881782 0.111320992324419 no 3035 0.0927475704680393 4372 646551 SGTC_1454 4239-0054 42.6 µM -1.32683446664424 0.11083382061255 no 3036 0.0922817231588796 4457 1340767 SGTC_1394 3474-0001 65.7 µM -1.3268469684952 0.110831657090349 no 3037 0.092279654945709 4353 5017666 YIL048W NEO1 SGTC_1509 1326-1131 80 µM -1.327432708599 0.110730325079741 no 3038 0.092182792916714 4365 768313 SGTC_407 eburnamonine 100 µM -1.32905025933732 0.110450836501324 no 3039 0.091915694491431 4227 3195 SGTC_1791 st048313 56.1 µM -1.33127330558712 0.11006755305772 no 3040 0.0915495492239562 4404 1204976 SGTC_351 caspofungin 25 nM -1.33301440369002 0.109768031070557 no 3041 0.0912635385228185 4385 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1271 0832-2808 169 µM -1.33370081556374 0.109650108229975 no 3042 0.0911509637023909 4424 3663794 SGTC_1426 4048-4480 71.7 µM -1.33449291952461 0.109514140979038 no 3043 0.091021182897892 4410 14224343 SGTC_2406 ethylparaben 405.7 µM -1.33575721852874 0.109297370825128 no 3044 0.0908143202275971 4370 8434 A possible steroid mimic. SGTC_413 propylparaben 100 µM -1.33734359107358 0.109025815871259 no 3045 0.0905552541053306 4378 7175 A pharmaceutical preservative. SGTC_1660 st012960 28.1 µM -1.34231203308751 0.108178457519194 no 3046 0.0897474217196876 4420 24207266 SGTC_736 0958-0254 92.6 µM -1.3433009278839 0.108010370589922 no 3047 0.0895872758909491 4458 6812352 SGTC_2585 alliin 100 µM -1.34465797090584 0.10778001405679 no 3048 0.0893678565908711 4448 87310 A garlic compound which reacts with lipids. SGTC_2159 5658611 73.75 µM -1.34612548298232 0.107531304031666 no 3049 0.0891310258124556 4388 793844 SGTC_1307 1187-1599 12.2 µM -1.34811093356064 0.10719547386001 no 3050 0.0888113526757251 4397 1538471 SGTC_1251 0490-5699 265 µM -1.34887343336065 0.107066701598726 no 3051 0.088688811371758 4418 3883818 SGTC_1798 st045719 60.953 µM -1.35253947081728 0.106449132619621 no 3052 0.0881014004486681 4360 3980186 SGTC_3255 9139072 49.47 µM -1.35422119543789 0.106166696805128 no 3053 0.0878329094181558 4399 17646060 SGTC_1523 st012844 44.7 µM -1.35667533808053 0.105755509897726 no 3054 0.0874421959688281 4458 4274103 SGTC_38 0929-0051 58.268 µM -1.35769286256053 0.105585363662771 no 3055 0.0872805812638611 4375 1379719 SGTC_1560 lithocholic acid 53.1 µM -1.35887889670585 0.105387289879549 no 3056 0.0870924835428532 4343 9903 A bile acid which acts as a detergent. SGTC_1216 1165-0504 9.65 µM -1.36062801699873 0.105095668538101 no 3057 0.08681563651876 4426 6304004 SGTC_2158 5657123 3.6195 µM -1.36133137553341 0.104978566178129 no 3058 0.0867044959943833 4393 2858827 SGTC_940 3232-1287 54.8 µM -1.36639814547438 0.104137788342294 no 3059 0.0859070152850684 4399 1585493 YIL048W NEO1 SGTC_3061 glucosamine 200 µM -1.36740021305101 0.103972085460486 no 3060 0.0857499478020539 4341 91431 and experimental redox chemotherapeutic SGTC_1946 st076057 65.1 µM -1.36954318847688 0.103618362780658 no 3061 0.0854147721381897 4385 953009 SGTC_3100 9120536 49.47 µM -1.37496445109276 0.1027274217093 no 3062 0.0845712330026585 4302 16421196 SGTC_566 0958-0068 16.5 µM -1.37786898464412 0.102252381589156 no 3063 0.0841218711911648 4325 6815365 SGTC_314 1671-0008 2.74 µM -1.38097482097219 0.101746188081542 no 3064 0.0836433513173523 4312 3913060 SGTC_387 norethindrone acetate 66.7 µM -1.38173830489027 0.101622034235184 no 3065 0.0835260342117437 4430 541197 SGTC_1810 st050138 53 µM -1.38422378843273 0.101218621798696 no 3066 0.0831449707535906 4429 3444541 SGTC_2374 9071832 200 µM -1.38946969921496 0.100371004736078 no 3067 0.0823449843487458 4362 17381698 SGTC_1023 4482-3888 16 µM -1.39032035955445 0.100234047341728 no 3068 0.0822158090591049 4431 3303168 SGTC_2510 benzyl isothiocyanate 8.31 µM -1.39047900722094 0.100208519965783 no 3069 0.0821917348372046 4438 2346 DNA damaging agent; causes G2/M arrest. SGTC_968 1309-0633 340 µM -1.39049500401095 0.100205946248236 no 3070 0.082189307675655 4461 3761976 SGTC_774 k060-0086 136 µM -1.39227317897478 0.0999201570583556 no 3071 0.0819198450875241 4421 5911235 SGTC_85 0868-0259 160.055 µM -1.39250145932709 0.0998835108830256 no 3072 0.0818853000214525 4355 83173 SGTC_1356 1502-0781 85.8 µM -1.39302908367651 0.0997988481493679 no 3073 0.0818054980269424 4433 567702 SGTC_2707 st078556 66.6 µM -1.39370325617498 0.0996907465623911 no 3074 0.081703616274246 4365 17250899 SGTC_836 0330-0104 1.35 µM -1.39580266069646 0.0993546612570693 no 3075 0.0813869644718039 4455 46494820 SGTC_2518 prenyletin 46.28 µM -1.39900719381513 0.0988432586158732 no 3076 0.0809054129178272 4440 3873459 A coumarin with calcium channel inhibitory activity. SGTC_2302 7771753 200 µM -1.40163272511582 0.0984256949231266 no 3077 0.0805124747352874 4410 2203047 SGTC_2133 5320837 200 µM -1.40304434859617 0.0982017253970667 no 3078 0.0803018073352661 4452 2841355 SGTC_674 0498-0004 451 µM -1.4055721057477 0.0978016022516349 no 3079 0.0799256119634565 4430 4231473 SGTC_206 4546-0025 72.014 µM -1.40714888766503 0.0975526166569723 no 3080 0.0796916220680117 4481 6620745 YIL048W NEO1 SGTC_169 k015-0017 16.025 µM -1.40904318017419 0.0972541088596276 no 3081 0.0794112002128088 4435 1840002 SGTC_1618 st003135 44.5 µM -1.41061428347759 0.0970070389971997 no 3082 0.0791791888299784 4419 1270615 SGTC_1525 8-methoxypsoralen 92.5 µM -1.41089778423301 0.0969625051160226 no 3083 0.0791373778090082 4481 4114 Related to psoralen; DNA damaging agent. SGTC_2921 7974240 10.71 µM -1.41263560699236 0.0966898461594939 no 3084 0.078881446953761 4517 2979074 YDR527W RBA50 SGTC_2348 9022543 33.42 µM -1.41455055897814 0.0963900488021604 no 3085 0.0786001567905678 4447 3162678 YDL140C RPO21 SGTC_2371 9071574 200 µM -1.414877502506 0.0963389321502452 no 3086 0.0785522076424473 4452 45596039 SGTC_2506 ethyl hematommate 54.16 µM -1.4185969766722 0.0957588053215662 no 3087 0.078008273907632 4475 3940691 An allergen. SGTC_1623 st003709 20.3 µM -1.41907631375526 0.0956842303955867 no 3088 0.0779383843089054 4415 16192618 SGTC_3137 9097352 49.47 µM -1.42033628162701 0.0954884092782543 no 3089 0.0777549016705545 4455 44120435 SGTC_3236 9132701 49.47 µM -1.42154526175307 0.0953007899998394 no 3090 0.0775791525366504 4450 24282524 SGTC_3181 9108277 49.47 µM -1.42230959780974 0.0951823142909819 no 3091 0.077468196923357 4414 17097298 SGTC_2144 5628481 200 µM -1.42266191398382 0.0951277401496557 no 3092 0.0774170931874897 4435 2818399 SGTC_570 0987-0065 62.6 µM -1.4264284103249 0.0945457454349352 no 3093 0.076872358909985 4300 3104428 SGTC_3010 9080089 71.4286 µM -1.42729065514007 0.0944128823722129 no 3094 0.0767480665323299 4465 17027233 SGTC_847 0342-0274 5.54 µM -1.43165823864844 0.0937419971295244 no 3095 0.0761208267715179 4447 18097 SGTC_1361 1608-0041 5.61 µM -1.43178486137975 0.0937225998015548 no 3096 0.0761027005387189 4442 X1361 SGTC_1472 k841-0093 193 µM -1.4322778259744 0.0936471108121043 no 3097 0.0760321632175417 4553 X1472 SGTC_309 k408-0051 1.48 µM -1.43269716953851 0.0935829309548134 no 3098 0.0759721993720838 4380 3640463 SGTC_790 1575-0012 79.1 µM -1.43385467165089 0.0934059456946066 no 3099 0.0758068697477606 4497 378741 YLR208W SEC13 SGTC_686 1319-0111 510 µM -1.43484749596134 0.0932543372144071 no 3100 0.0756652800086444 4470 4562600 SGTC_967 1306-0166 352 µM -1.44222488059849 0.0921334706474225 no 3101 0.0746194718961312 4466 4437607 SGTC_2925 9010536 32.5 µM -1.44433503534852 0.0918147108086307 no 3102 0.0743223775612536 4378 2994177 SGTC_1453 4237-0541 195 µM -1.44572760136516 0.0916047977738672 no 3103 0.0741268097502582 4457 739892 SGTC_1167 k781-0610 148 µM -1.44685275056211 0.0914354546035066 no 3104 0.0739690844658888 4491 4525169 SGTC_1553 gossypol 38.6 µM -1.44783596636899 0.0912876635208879 no 3105 0.0738314656994789 4366 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1034 k072-0165 12.7 µM -1.44919748110832 0.0910833013563422 no 3106 0.0736412203903651 4480 5835461 SGTC_2156 5649887 115 µM -1.45198476578085 0.0906659910762891 no 3107 0.0732529206042982 4490 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_1691 st019933 84.6 µM -1.4528083641515 0.0905429545396772 no 3108 0.0731384845025359 4446 6176082 SGTC_1220 1838-0075 193 µM -1.45535264974653 0.0901636491922479 no 3109 0.0727858289222564 4404 5529645 SGTC_2218 6965428 192.983 µM -1.45607673632628 0.0900559175137015 no 3110 0.0726857038799409 4383 675684 SGTC_185 k048-0037 25.491 µM -1.45701077453942 0.0899170899254958 no 3111 0.0725567030287614 4514 6827589 SGTC_1282 0886-0010 32.4 µM -1.45876417676602 0.0896569085947223 no 3112 0.0723150127723489 4490 2836211 YNL267W PIK1 SGTC_1215 3852-0577 11.2 µM -1.45993966633068 0.089482795425431 no 3113 0.0721533281750977 4491 2884876 SGTC_4 0960-0234 25.671 µM -1.46324938928328 0.0889939112297693 no 3114 0.0716995754150536 4469 6821112 SGTC_3108 9121785 49.47 µM -1.46589563267505 0.0886044630975219 no 3115 0.0713383609723233 4346 17140271 SGTC_2123 5259487 200 µM -1.46618907238887 0.0885613558321994 no 3116 0.071298392394339 4485 2173474 SGTC_1501 4491-0275 38.4 µM -1.46799673603198 0.0882961485606029 no 3117 0.0710525547552228 4479 5104718 SGTC_3174 9107204 49.47 µM -1.4741425315969 0.0873989089183788 no 3118 0.0702216095585713 4485 3938802 SGTC_653 0203-0016 55.2 µM -1.47489910817197 0.0872889266339603 no 3119 0.0701198350748534 4547 295302 SGTC_1410 3909-8106 77.9 µM -1.47788625592751 0.0868556991521185 no 3120 0.0697191128373261 4537 1039210 SGTC_1616 st002734 56.1 µM -1.48689642532757 0.0855586817631888 no 3121 0.0685210842681337 4453 4026101 SGTC_2458 5808907 16.39 µM -1.4874339351714 0.0854817679197533 no 3122 0.0684501198627554 4600 2731747 SGTC_3203 9113543 49.47 µM -1.48967075750044 0.0851622505870474 no 3123 0.0681554135793323 4505 17018012 SGTC_535 2293-4129 48.2 µM -1.4901456888933 0.0850945246717742 no 3124 0.0680929665554768 4488 396118 YIL048W NEO1 SGTC_2487 5918373 44.05 µM -1.49541282125 0.0843461279493809 no 3125 0.0674033682354754 4547 2876279 SGTC_1401 3807-4679 7.6 µM -1.4962207294772 0.0842317720796471 no 3126 0.0672980721693625 4429 3291456 SGTC_1213 1315-0166 115 µM -1.49876154963351 0.0838728885773602 no 3127 0.0669677514205302 4494 768401 SGTC_894 0960-0238 55.9 µM -1.49973980506384 0.0837350194343275 no 3128 0.0668409076682615 4495 6741907 YDL195W SEC31 SGTC_1859 st055998 20 µM -1.50429863553608 0.0830947712403198 no 3129 0.066252245129816 4425 676301 SGTC_2263 7948595 193.29 µM -1.50510944051276 0.0829812873560209 no 3130 0.0661479711420222 4513 2971371 SGTC_161 4065-0411 162.148 µM -1.50775005704277 0.0826125029447796 no 3131 0.0658092543811312 4483 1906281 YLR208W SEC13 SGTC_175 3793-3120 23.7 µM -1.5079209214825 0.0825886828429767 no 3132 0.0657873836770296 4491 5322297 SGTC_875 0709-0210 25.7 µM -1.50884650261768 0.0824597380168792 no 3133 0.0656690068961932 4472 6251364 SGTC_928 2764-0428 58.7 µM -1.51360827031822 0.0817987599723525 no 3134 0.0650626111515868 4520 662578 SGTC_1515 3460-0031 42.1 µM -1.52415119793991 0.0803495229957702 no 3135 0.0637354728593903 4477 2876596 SGTC_1482 3346-2049 8.48 µM -1.52701087931357 0.0799597945574864 no 3136 0.0633791530544144 4550 3826804 SGTC_1354 1498-1681 81 µM -1.52730441063028 0.0799198720032133 no 3137 0.0633426666186094 4519 5754243 SGTC_1921 5740136 50 µM -1.53381166753117 0.079038700518367 no 3138 0.0625379958911476 4459 1774243 SGTC_2879 9041815 71.43 µM -1.53581278704874 0.0787692063237845 no 3139 0.0622921513306827 4552 4942971 SGTC_1084 voriconazole 435 nM -1.5359273632592 0.0787537972486604 no 3140 0.0622780980872446 4532 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1209 2323-2347 50.3 µM -1.54038237944406 0.0781564224250895 no 3141 0.0617335869669596 4529 5412760 SGTC_2455 5377712 9.75 µM -1.54131994214983 0.0780311432059504 no 3142 0.0616194688519008 4513 2243908 SGTC_3155 9099265 49.47 µM -1.54333674758563 0.0777621696077395 no 3143 0.0613745459659177 4489 25236499 SGTC_186 3455-3465 67.277 µM -1.54398057557443 0.0776764530969218 no 3144 0.0612965191898089 4520 755278 SGTC_2743 auranofin 4.32 µM -1.5488444508183 0.0770312137713782 no 3145 0.0607095585395354 4585 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_623 k072-0108 16.9 µM -1.54903739187752 0.0770057025588146 no 3146 0.0606863658475203 4495 5382803 SGTC_110 0850-0284 111.64 µM -1.55112948359577 0.076729492447834 no 3147 0.0604353284160843 4433 3906265 SGTC_763 3453-1109 128 µM -1.55226850013104 0.0765794299359438 no 3148 0.0602989958631832 4549 1560353 SGTC_2299 7976368 114.88 µM -1.55497451329716 0.0762238148599566 no 3149 0.0599760697067217 4517 2979718 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -1.55726542668658 0.0759237343979857 no 3150 0.0597037401402806 4540 5393153 SGTC_2738 aclarubicin 5.55 µM -1.5592096218647 0.0756697759870939 no 3151 0.0594733871250829 4574 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1003 4049-0218 100 µM -1.56203801547314 0.0753014763239824 no 3152 0.059139516758528 4535 295161 SGTC_569 4130-2812 160 µM -1.56786311939444 0.0745472668777904 no 3153 0.0584565402290521 4406 743552 SGTC_2716 st080858 38.6235 µM -1.56793225396019 0.0745383503820981 no 3154 0.0584484717521979 4521 5296050 SGTC_1972 st070201 17.4 µM -1.56844328499098 0.0744724663992214 no 3155 0.0583888580555926 4546 2829099 SGTC_676 falcarinol 140 µM -1.57378779420036 0.0737860941007067 no 3156 0.0577682584031952 4549 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_3292 9120825 59.784 µM -1.5742854170234 0.0737224334083607 no 3157 0.0577107398091199 4505 24824900 SGTC_1787 fluconazole 80 µM -1.57598811366307 0.0735049256746793 no 3158 0.0575142712797051 4195 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_173 1273-0061 2.693 µM -1.58398994774062 0.0724893135847279 no 3159 0.0565980033290714 4488 2847414 YPL266W DIM1 SGTC_2252 omeprazole 400 µM -1.59420149174367 0.0712088947620869 no 3160 0.0554454562602896 4583 4594 A proton pump inhibitor. SGTC_2289 7946404 165.07 µM -1.59705241163582 0.0708545387621485 no 3161 0.0551270123682841 4520 1246120 YPR165W RHO1 SGTC_895 0964-0006 13.7 µM -1.59988122071733 0.070504271576103 no 3162 0.0548124680487254 4548 6738897 SGTC_1715 st032160 10.2275 µM -1.60293516965658 0.0701276230633252 no 3163 0.0544744839878139 4446 5289825 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -1.60455232220792 0.0699288047878674 no 3164 0.0542961805449428 4482 4000243 SGTC_485 niflumic acid 177 µM -1.61173373247235 0.0690511337453964 no 3165 0.0535099469558938 4592 4488 A COX2 inhibitor. SGTC_2211 7117706 200 µM -1.61632941982468 0.0684939454660285 no 3166 0.0530115546521051 4530 822771 SGTC_322 k048-0136 19.3 µM -1.61682611661803 0.0684339334592815 no 3167 0.0529579101273372 4599 6823282 SGTC_360 0957-0399 1.01 µM -1.61924028424382 0.0681428259753482 no 3168 0.0526977867675708 4566 6752301 YPR165W RHO1 SGTC_440 fluspirilene 35.1 µM -1.62661533284066 0.0672594395377006 no 3169 0.0519094103962544 4573 3396 An atypical antipsychotic. SGTC_565 1418-0001 44.5 µM -1.6277583436553 0.0671233252270409 no 3170 0.0517880682538477 4590 2862145 SGTC_1570 verbenone 133 µM -1.6290463999077 0.0669701937017937 no 3171 0.0516515983618712 4572 29025 A natural terpanoid with antifungal properties. SGTC_111 0083-0039 52.457 µM -1.63117568910087 0.0667176443243032 no 3172 0.0514266267416167 4539 759313 SGTC_1223 0764-0573 147 µM -1.63217992919773 0.0665987901084989 no 3173 0.0513207938123004 4558 1609797 SGTC_3136 9095672 49.47 µM -1.63355896393349 0.0664358451742993 no 3174 0.0511757451409425 4421 17217380 SGTC_2519 cryptotanshinone 88.04 µM -1.63626786587959 0.0661166637412288 no 3175 0.0508917691524549 4568 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_1218 1348-1416 30.7 µM -1.63743597541907 0.0659793961597155 no 3176 0.0507697032112982 4538 6787668 SGTC_2175 5807670 165.306 µM -1.63928559981373 0.0657624937918872 no 3177 0.0505768968185141 4529 241186 SGTC_1764 st044502 93.5 µM -1.65366579502374 0.0640949583793686 no 3178 0.0490977180847244 4589 8407 SGTC_1552 6-methylflavone 10.6 µM -1.65789840427448 0.0636104569077484 no 3179 0.0486689871578389 4523 689013 SGTC_1172 0370-0043 85 µM -1.65894725603201 0.0634908378560955 no 3180 0.0485632105194611 4589 376585 SGTC_1976 st070609 63.5 µM -1.66087208564398 0.0632717711325046 no 3181 0.048369569813726 4526 682556 SGTC_1499 4480-0877 67.3 µM -1.6623114635268 0.0631083390601454 no 3182 0.0482251702392637 4572 2861909 SGTC_2584 androsterone 48.74 µM -1.66373575021148 0.0629469442961828 no 3183 0.0480826243108044 4466 2754130 A steroid. SGTC_2046 4110841 106 µM -1.66553464209605 0.0627435604249629 no 3184 0.0479030691125039 4584 44119630 YMR134W ERG29 SGTC_1059 3448-6867 171 µM -1.66706302454343 0.0625711632263478 no 3185 0.0477509367466407 4543 3934407 SGTC_45 0kpi-0036 14.9 µM -1.66779241634156 0.0624890201694788 no 3186 0.0476784709312763 4556 2795021 SGTC_3178 9107506 49.47 µM -1.671738559537 0.0620460682198398 no 3187 0.0472879435015807 4554 8897194 SGTC_651 3253-0966 34.4 µM -1.67447784186598 0.0617400289117873 no 3188 0.047018362813408 4595 781462 SGTC_2254 7938975 95.19 µM -1.67651496076326 0.0615132020562255 no 3189 0.0468186841348762 4613 2969277 SGTC_2107 5363541 170.161 µM -1.6798826472345 0.0611396485959973 no 3190 0.0464900753324886 4525 244052 SGTC_2373 9071805 200 µM -1.68063962758024 0.061055926698625 no 3191 0.0464164668658389 4583 10149009 SGTC_1531 st059297 52.4 µM -1.68088807043404 0.06102846850142 no 3192 0.0463923287836305 4598 7566702 SGTC_32 0928-0142 34.1 µM -1.68560975395122 0.0605084553466883 no 3193 0.0459354946348937 4594 2244242 SGTC_728 3030-5151 22.5 µM -1.68876990942269 0.0601623589822348 no 3194 0.0456317662059495 4643 3125388 SGTC_1369 1866-0067 208 µM -1.69307203771328 0.059693688513711 no 3195 0.0452208780044453 4593 3531355 SGTC_2711 st079103 59.1 µM -1.69475438800041 0.0595111945502107 no 3196 0.0450610117148102 4522 54693780 SGTC_978 1416-0512 87.4 µM -1.69677192366117 0.059292918134813 no 3197 0.044869894387173 4611 6814003 SGTC_3142 9086498 49.47 µM -1.69925085886582 0.0590255831581396 no 3198 0.0446359636677783 4453 25236367 SGTC_606 k015-0008 38.6 µM -1.70265108184947 0.0586604331271674 no 3199 0.0443166922536822 4645 1970475 SGTC_1350 1495-0454 146 µM -1.70458551131874 0.0584534874514772 no 3200 0.044135877720525 4614 1069057 SGTC_1500 4488-1866 171 µM -1.7055847596927 0.058346812442638 no 3201 0.0440427094464506 4633 2900003 SGTC_572 0960-0087 17.7 µM -1.7113088982266 0.0577386745507268 no 3202 0.0435120522958022 4547 6796365 SGTC_2740 felodipine 17.08 µM -1.71348520777894 0.0575087732640904 no 3203 0.0433116562034203 4653 3333 L-type calcium channel blocker SGTC_211 3455-0679 143.504 µM -1.7141196421352 0.0574418885300817 no 3204 0.0432533775458009 4563 748649 SGTC_183 3914-0051 30.55 µM -1.71683436542976 0.0571563819358561 no 3205 0.0430047199835276 4591 1596232 SGTC_3199 9111318 49.47 µM -1.72329427762328 0.0564814862067139 no 3206 0.0424176610329692 4516 8548020 SGTC_2429 5902844 64.44 µM -1.72393688149803 0.0564146954044281 no 3207 0.042359619163117 4583 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_2938 9059746 27.26 µM -1.73820617458938 0.0549475557526664 no 3208 0.0410872457570838 4572 6471769 SGTC_1938 st074717 56.4 µM -1.74349661606508 0.0544113279053786 no 3209 0.0406234524376867 4484 17250979 SGTC_2873 9040596 71.43 µM -1.76473781241505 0.0522999254441734 no 3210 0.0388039202467605 4576 6463863 SGTC_1007 4101-0031 70 µM -1.7663973541775 0.0521377436639787 no 3211 0.0386646043405924 4609 1146276 SGTC_2166 5933061 31.504 µM -1.76679714977901 0.0520987326725432 no 3212 0.0386311031165797 4598 2877375 SGTC_2834 9001755 58.44 µM -1.76918725440915 0.0518659960539705 no 3213 0.038431315240973 4467 2989575 SGTC_974 1326-0144 138 µM -1.77034065160078 0.0517539798631538 no 3214 0.0383352049586229 4621 5411856 SGTC_2863 9028737 58.44 µM -1.77319005509165 0.0514780743632222 no 3215 0.0380986097011834 4617 6460917 SGTC_1150 3909-7983 10.9 µM -1.7758664186146 0.0512199907428116 no 3216 0.0378774685625263 4624 23965914 SGTC_695 3505-6186 243 µM -1.78265077047849 0.0505703821138541 no 3217 0.0373215848679126 4610 1819379 SGTC_1927 st060202 13.8 µM -1.79062725230352 0.0498150384672433 no 3218 0.0366765653874202 4567 688887 SGTC_2048 5246248 200 µM -1.79074484586868 0.0498039704768947 no 3219 0.0366671248064589 4646 677046 SGTC_2708 st078559 56 µM -1.79441943886754 0.0494591024691045 no 3220 0.03637312326794 4588 17250902 SGTC_617 3770-0098 35 µM -1.79471063933816 0.0494318544312747 no 3221 0.0363499072709304 4573 5962639 SGTC_2426 5582046 32.21 µM -1.79637844723023 0.0492760260775215 no 3222 0.0362171746116421 4596 2251934 SGTC_1561 5-methoxyflavone 52.9 µM -1.79749709950659 0.0491717269544438 no 3223 0.0361283690910078 4597 94525 SGTC_2843 9000894 45.46 µM -1.79857871915375 0.0490710483463804 no 3224 0.0360426730795327 4640 2242070 SGTC_39 0986-0283 58.349 µM -1.8015146128473 0.0487986013340619 no 3225 0.0358109030906589 4641 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2959 9079155 11 µM -1.80220923927021 0.0487343181033477 no 3226 0.0357562458065796 4626 16189457 SGTC_924 2046-0044 21.3 µM -1.80415512151685 0.0485545994855666 no 3227 0.0356034962668808 4596 3623589 SGTC_3334 9142812 21.919 µM -1.80648776073541 0.0483398593916111 no 3228 0.0354210921143499 4611 45283678 SGTC_3253 9135987 49.47 µM -1.80740390261093 0.0482557284662631 no 3229 0.035349662956065 4642 4182430 SGTC_2219 9098279 200 µM -1.81103006918064 0.0479238799653626 no 3230 0.0350680986142769 4597 902349 SGTC_2357 9067248 200 µM -1.81125338029592 0.0479035035189089 no 3231 0.0350508192973496 4585 9150235 SGTC_1717 st033143 58.0435 µM -1.81353904748689 0.0476953420300566 no 3232 0.0348743608903726 4623 674616 SGTC_1875 nocodazole 6 µM -1.81401740234921 0.0476518688437404 no 3233 0.0348375233070155 4650 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_1373 2887-0003 58.5 µM -1.83242066255969 0.04600332873838 no 3234 0.0334443859747676 4601 776948 SGTC_152 4469-0003 551.229 µM -1.83719955425577 0.0455828212809029 no 3235 0.0330902207334458 4625 697280 SGTC_2504 purpurogallin 52.29 µM -1.83936950756028 0.0453929042389815 no 3236 0.0329304279531068 4598 5281571 An antioxidant. SGTC_2662 daunorubicin 22.37 µM -1.84445978756951 0.0449498936046435 no 3237 0.0325580805174707 4533 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_874 0599-0792 117 µM -1.84636174082939 0.0447852610894796 no 3238 0.0324198492610662 4625 765305 SGTC_2482 5981709 142.65 µM -1.84869036443062 0.0445843576174829 no 3239 0.0322512679153126 4596 877755 SGTC_1309 pyrazolanthrone 13.4 µM -1.84992981105414 0.0444777199847627 no 3240 0.0321618332815865 4643 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_1061 3448-9325 110 µM -1.85305939546019 0.0442093758883949 no 3241 0.0319369229443039 4616 723482 SGTC_3237 9133362 49.47 µM -1.85497274248134 0.0440459611000388 no 3242 0.0318000595370505 4639 43845137 SGTC_1491 4138-0063 26.5 µM -1.8594502128585 0.043665453366038 no 3243 0.0314816750299195 4667 23883227 SGTC_2077 5212015 200 µM -1.8601235773637 0.0436084591336473 no 3244 0.0314340220740485 4586 780900 SGTC_2595 hexamethylquercetagetin 100 µM -1.86233736257247 0.0434215051994191 no 3245 0.0312777760827859 4605 386331 SGTC_2685 mycophenolic acid 18.85 µM -1.86442192700553 0.0432460559555674 no 3246 0.0311312380108337 4658 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2612 dictamnine 15.46 µM -1.87086148942404 0.0427076777239574 no 3247 0.0306821410288197 4557 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_1321 1326-2144 215 µM -1.87664411692782 0.0422288517893969 no 3248 0.0302834432731121 4634 3513030 SGTC_11 0438-0307 1.3 µM -1.87750757671835 0.0421577278577335 no 3249 0.0302242799381214 4643 4011476 SGTC_1935 st074532 41.6 µM -1.88501924463547 0.0415430670207608 no 3250 0.0297136198194088 4617 2829742 SGTC_2899 9053889 58.44 µM -1.90198304912896 0.0401816608188282 no 3251 0.0285866853406049 4661 6470052 SGTC_140 0062-0056 502.533 µM -1.90363598535028 0.0400509672600406 no 3252 0.0284788043965533 4577 3758964 SGTC_587 k089-0003 57 µM -1.90473011117656 0.0399646475915799 no 3253 0.0284075813788605 4606 9659696 SGTC_816 0325-0417 81.3 µM -1.90644468691493 0.0398296824772208 no 3254 0.0282962678206668 4669 68101 SGTC_2444 5485484 36.41 µM -1.90981186220551 0.0395657091261476 no 3255 0.0280787207079028 4679 6790631 SGTC_862 0452-0056 10.2 µM -1.92054937117196 0.0387334202962275 no 3256 0.0273942716037266 4634 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_490 phenamil 164 µM -1.9213805286098 0.0386695946213508 no 3257 0.0273418757423071 4682 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_996 3970-0799 1.8 µM -1.92309775551774 0.0385379979071259 no 3258 0.0272338870906695 4619 6615648 YGL040C HEM2 SGTC_2057 5236571 38.335 µM -1.93432968925163 0.0376862328073865 no 3259 0.0265363025727054 4609 54684039 YBR257W POP4 SGTC_3226 9131256 49.47 µM -1.93868009553106 0.0373604794472701 no 3260 0.0262701519089305 4699 17178073 SGTC_1082 camptothecin 424.86 nM -1.9391067148852 0.037328658900132 no 3261 0.0262441726147595 4550 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1026 k007-1105 30.6 µM -1.9397949110642 0.0372773746111517 no 3262 0.0262023096837252 4630 7066794 SGTC_1620 st003704 16.5 µM -1.94756360722095 0.0367024353545663 no 3263 0.0257336009467723 4681 2834414 SGTC_715 0868-0130 184 µM -1.95678036120772 0.036029757541778 no 3264 0.025186648490914 4712 2876258 SGTC_2550 chrysin dimethyl ether 71.87 µM -1.9671548507821 0.0352846979270753 no 3265 0.0245826806533582 4586 88881 An O-methylated flavonoid and antioxidant. SGTC_1015 4130-4525 82 µM -1.96976770767179 0.0350990572806785 no 3266 0.0244324995568261 4667 1363237 SGTC_1138 3761-0006 1.03 µM -1.97113741740881 0.0350020615279319 no 3267 0.0243540799355743 4693 12061087 SGTC_426 0988-0037 14.6 µM -1.97229802310821 0.0349200457163957 no 3268 0.0242877975922301 4658 5383008 SGTC_2820 7989630 71.43 µM -1.97293817841565 0.0348748757961149 no 3269 0.0242513031038748 4702 2984098 SGTC_1176 0848-0131 83.3 µM -1.97525342871413 0.0347119099814864 no 3270 0.024119697700912 4701 6769040 SGTC_2825 7998094 58.44 µM -1.97700317277992 0.034589164344059 no 3271 0.0240206357803358 4635 2987815 SGTC_3312 9133330 71.43 µM -1.98709202389718 0.033888361384913 no 3272 0.0234560999868767 4690 17617324 SGTC_2221 6807166 181.081 µM -2.00386970639525 0.0327488188249414 no 3273 0.0225420096910864 4693 674925 SGTC_2393 9031399 185.94 µM -2.01217699019026 0.0321963904561853 no 3274 0.0221006415666383 4660 1526623 YDL150W RPC53 SGTC_3308 9128332 17.569 µM -2.01387945188899 0.0320841330202998 no 3275 0.0220110956913737 4651 17332805 YDL196W YDL196W SGTC_3204 9114183 49.47 µM -2.01556648608763 0.0319732118179204 no 3276 0.0219226636057894 4633 17027248 SGTC_699 0375-0592 111 µM -2.01621086729278 0.0319309279154852 no 3277 0.0218889652709161 4733 762578 SGTC_1324 1418-0026 34.4 µM -2.01731402944106 0.0318586463029021 no 3278 0.0218313762321266 4705 1372513 SGTC_2270 7924575 90.91 µM -2.02070671473384 0.0316371966427853 no 3279 0.0216550671665297 4654 1262135 SGTC_2340 7987427 183.45 µM -2.04620809752448 0.0300130566064004 no 3280 0.0203679504988358 4663 2239331 SGTC_1813 st051246 8.6015 µM -2.04625434903251 0.0300101749598951 no 3281 0.0203656763077397 4674 5291959 SGTC_2819 7996655 46.38 µM -2.05507029400239 0.0294650823351408 no 3282 0.0199361078331817 4675 6456960 SGTC_131 0141-0277 33.849 µM -2.06406043693225 0.0289177094752915 no 3283 0.0195059932427085 4647 1547771 SGTC_1630 st005209 31.3 µM -2.06911160529488 0.0286138907836541 no 3284 0.0192678074747017 4693 3367314 SGTC_687 k029-0044 34.9 µM -2.07249636908915 0.028411792551143 no 3285 0.0191095872543064 4722 5829338 SGTC_3144 9087057 49.47 µM -2.07666397265885 0.0281645852733591 no 3286 0.0189162919910653 4643 17249618 SGTC_1799 st045822 46.1415 µM -2.08068188691767 0.0279279549779239 no 3287 0.0187315165359126 4690 3674992 SGTC_198 3454-2873 16.191 µM -2.08896521743218 0.0274453420634265 no 3288 0.018355427160873 4715 710957 SGTC_631 k072-0230 41.5 µM -2.11587731533427 0.0259251140433822 no 3289 0.0171776216107042 4713 5773147 SGTC_427 1354-0053 47.3 µM -2.11795112950254 0.025810949483255 no 3290 0.017089603379814 4703 6813657 SGTC_2448 5185112 27.17 µM -2.13794640624247 0.0247316297252619 no 3291 0.0162605466187947 4703 5718189 SGTC_3017 9080681 49.47 µM -2.1398235272032 0.0246322781309678 no 3292 0.0161845155528373 4722 16451914 SGTC_657 3534-0529 86.7 µM -2.14500435016266 0.0243598055870517 no 3293 0.0159762495891528 4726 1049549 SGTC_2200 6600604 21.907 µM -2.15211524512498 0.0239899497133734 no 3294 0.0156941393615916 4726 2904777 SGTC_515 4092-1064 102 µM -2.15360638110344 0.0239129933910481 no 3295 0.0156355267157098 4670 717353 SGTC_3340 9146634 11.102 µM -2.1566639500577 0.0237558435036835 no 3296 0.0155159289075026 4706 4907387 SGTC_2188 6126565 140.678 µM -2.15859090172745 0.0236572507018615 no 3297 0.015440959617325 4679 874518 SGTC_2174 5790901 200 µM -2.15966935169497 0.0236022219718331 no 3298 0.0153991377114537 4689 786020 SGTC_3034 9090421 49.47 µM -2.16333377568359 0.0234160456895786 no 3299 0.0152577585382154 4699 17173761 SGTC_2022 5136654 200 µM -2.16807847274326 0.0231768218203675 no 3300 0.0150763582212587 4686 1713771 SGTC_1851 st056236 18.9 µM -2.18824382544276 0.0221829327213679 no 3301 0.0143259231680819 4702 5393171 SGTC_2619 obliquin 87.91 µM -2.19285991007201 0.0219605495654383 no 3302 0.0141587369551811 4710 6708593 A bioactive alkalod. YER133W GLC7 SGTC_3139 9095020 49.47 µM -2.22219927665669 0.0205906730159112 no 3303 0.013134920666302 4664 25236292 SGTC_450 aminopyrene 156 nM -2.2338515552849 0.0200670667886087 no 3304 0.012746421005837 4710 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1656 st012921 11 µM -2.2356592606119 0.0199868564797315 no 3305 0.0126870497803988 4663 6732821 SGTC_2536 dehydroabietamide 32.04 µM -2.24608774600951 0.0195294225407156 no 3306 0.0123491940462802 4722 3983547 SGTC_2827 7993847 71.43 µM -2.24658999820063 0.0195076180947631 no 3307 0.0123331209841442 4731 2985692 SGTC_3354 9151612 71.43 µM -2.27089754695162 0.0184767847854567 no 3308 0.0115765903999009 4709 27261949 SGTC_1767 st044992 70.3 µM -2.27532399139623 0.0182941498204296 no 3309 0.0114432506319921 4724 9600693 SGTC_2243 6634756 200 µM -2.3005048125488 0.0172841972342629 no 3310 0.0107098184765003 4725 885676 SGTC_577 r071-0003 38.6 µM -2.31658041759434 0.0166646628268479 no 3311 0.0102632995591093 4722 4568517 YMR134W ERG29 SGTC_491 tetrandrine 80.3 µM -2.31807235492214 0.0166081410735461 no 3312 0.0102226945329387 4752 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_290 2043-6722 48.1 µM -2.37174445361785 0.0146810955323279 no 3313 0.00885216544535623 4763 773758 YLR208W SEC13 SGTC_2515 chrysin 20.77 µM -2.37203657294655 0.0146711573467628 no 3314 0.00884516977415126 4759 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_2481 5478948 45.16 µM -2.39746362792734 0.0138279936748712 no 3315 0.00825450995770612 4732 77792 SGTC_3246 9135460 32.98 µM -2.40052916549232 0.0137292195955758 no 3316 0.00818569303431064 4759 41446951 SGTC_2160 5660466 132.927 µM -2.41406291449885 0.0133003929960393 no 3317 0.00788786903068812 4747 2859134 SGTC_2275 7947463 200 µM -2.4191902811351 0.0131409772671579 no 3318 0.00777755046940101 4732 1225414 SGTC_2839 9003951 25.97 µM -2.4297277112642 0.0128185334676201 no 3319 0.00755508491134035 4760 2990634 SGTC_1101 ebselen 5.29 µM -2.43883858218044 0.0125452816483605 no 3320 0.00736727414955575 4772 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_729 4092-0585 94.1 µM -2.44363733501736 0.0124033963431188 no 3321 0.00727001722556533 4756 2169061 SGTC_997 3996-0078 137 µM -2.51062456196951 0.0105632373886395 no 3322 0.00602588976433806 4768 735687 SGTC_564 3555-0129 330 µM -2.5698323472892 0.00913958992968476 no 3323 0.00508738712745884 4764 563260 SGTC_26 0302-0163 425.158 µM -2.59247261520607 0.00864133946018019 no 3324 0.00476443836037185 4792 3100915 SGTC_909 3448-9333 149 µM -2.60518567511396 0.00837213728134333 no 3325 0.00459122418532993 4748 3344074 SGTC_2793 7325131 81.82 µM -2.60704468861691 0.00833339566642584 no 3326 0.00456637200765548 4753 4176441 SGTC_1825 st052143 62.6 µM -2.64266764474871 0.00762083157122672 no 3327 0.00411278666074064 4785 674173 SGTC_1184 1269-1718 139 µM -2.65216130464681 0.00744022475327915 no 3328 0.00399891616421616 4785 5403821 SGTC_1953 st076800 12.1 µM -2.67188405135076 0.00707703436219345 no 3329 0.00377133529511675 4744 297591 SGTC_2006 4011487 200 µM -2.68801634060153 0.00679168645906314 no 3330 0.0035938939574489 4734 45595294 SGTC_694 1315-0438 43.2 µM -2.69414330723463 0.00668600538647613 no 3331 0.00352849077048865 4787 6793154 SGTC_1811 st050069 61.5 µM -2.71303090647341 0.00636931179713777 no 3332 0.00333354440227712 4784 3877702 SGTC_1113 artemisinin 1.17947 µM -2.77939445978299 0.00535929939195669 no 3333 0.00272301737406742 4784 2240 An anti-malaria and mitochondrial poison. SGTC_2602 kawain 100 µM -2.86716176684189 0.00424317514750516 no 3334 0.00207085625767498 4769 5369129 SGTC_2766 oltipraz 83.91 µM -2.89914659745073 0.00389128968699167 no 3335 0.00187089949734415 4784 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_2014 4013930 200 µM -2.91528946575456 0.00372381695711425 no 3336 0.00177679388607558 4767 64556 SGTC_487 nimodipine 119 µM -2.96232300530329 0.00327210387786427 no 3337 0.00152663647582894 4800 4497 L-type voltage-gated calcium channels inhibitor SGTC_779 1360-0071 233 µM -2.98464665259603 0.00307547420699108 no 3338 0.00141953035978454 4787 7566 SGTC_2763 lisinopril 49.32 µM -3.04332346280287 0.00260837888227414 no 3339 0.00116990340680905 4775 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_603 3794-0023 45.9 µM -3.1901004602702 0.00170744498367515 no 3340 0.000711116726341712 4800 3802260 SGTC_2626 ethyl orsellinate 100 µM -3.24924067802317 0.00143267096758037 no 3341 0.000578567645657108 4778 75653 A natural product. SGTC_538 2922-0838 53.3 µM -3.27072307806077 0.00134330454467514 no 3342 0.000536364492623262 4800 777039 SGTC_80 0159-0065 512.242 µM -3.30190345906837 0.00122263592460696 no 3343 0.000480155581234158 4800 1548079 SGTC_2807 7945238 51.95 µM -3.32514604097699 0.00113923186887712 no 3344 0.000441861159219854 4784 17148797 SGTC_473 2-arachidonoylglycerol 10 µM -3.39654330214356 0.000914550615768442 yes 3345 0.000341213794758523 4738 5282280 An endocannabinoid. SGTC_1133 3473-0247 50 µM -3.54067393304372 0.000579878073084702 yes 3346 0.000199553238448779 4789 711311 SGTC_1392 3455-1037 33.9 µM -3.5701263568561 0.000527268979831244 yes 3347 0.000178404536125399 4802 981132 SGTC_464 bw-b 70c 158 µM -3.61353073088513 0.000457743208935791 yes 3348 0.000151027768076958 4802 5353454 SGTC_2452 5863136 48.41 µM -3.68293373133523 0.000363990860249268 yes 3349 0.000115282556186054 4796 2184096 SGTC_732 3970-1727 52.7 µM -3.68979484616272 0.000355763538956188 yes 3350 0.000112217485767939 4808 1275699 SGTC_462 ag-879 158 µM -3.80019921176509 0.000245004067897524 yes 3351 7.22899066709687e-05 4804 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_727 3032-0951 202 µM -3.83180486456795 0.000219801801953661 yes 3352 6.36033090708671e-05 4806 3652836 SGTC_563 tetrahydrosecaminediol 614 µM -3.95605904879241 0.00014235437798577 yes 3353 3.80981672500863e-05 4810 334274 A psychoactive constituent of the cannabis plant. SGTC_438 sphingosine 6.67 µM -5.15997816017586 1.11781866307703e-06 yes 3354 1.2348932606513e-07 4806 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.