SGTCid condition conc unit YCR013C|YCR013C.score YCR013C|YCR013C.strain.pval YCR013C|YCR013C.strain.significant YCR013C|YCR013C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_563 tetrahydrosecaminediol 614 µM 6.53352772889447 3.03110584569402e-13 yes 1 3.21191468743911e-11 1 334274 A psychoactive constituent of the cannabis plant.
SGTC_1934 st074720 32.6 µM 4.22865534386317 1.6863374065702e-06 yes 2 1.17546083145057e-05 9 17250992
SGTC_662 k832-1615 104 µM 4.01006740594335 5.29767502418692e-06 yes 3 3.0350708295174e-05 4 5878478
SGTC_153 4077-0274 519.67 µM 3.83912332812922 1.24693863988305e-05 yes 4 6.17372004036567e-05 8 3121976
SGTC_1927 st060202 13.8 µM 3.7042596973373 2.39126349860922e-05 yes 5 0.000106004488026879 9 688887
SGTC_2789 5281112 71.43 µM 3.23218275584648 0.000197620831662514 yes 6 0.000614242299789214 15 765948
SGTC_3012 9080433 71.4286 µM 3.22871683630341 0.000200516791236679 yes 7 0.000621734754712737 12 17688859
SGTC_1787 fluconazole 80 µM 3.17291695999212 0.000252951603642818 yes 8 0.000754578412440352 20 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2760 etidronate 98.04 µM 3.11303898870051 0.000323265225203642 yes 9 0.000925857768385724 16 3305 A chelator and antioxidant.
SGTC_2969 9091408 28.7 µM 3.09179620057206 0.000352303942081895 yes 10 0.000994746932542317 18 4286311
SGTC_2418 pentamidine 31.67 µM 3.09061617772132 0.000353986024940089 yes 11 0.000998708236263378 25 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_2628 lathosterol 100 µM 3.08604043682904 0.000360579413696452 yes 12 0.00101420617385654 11 6710616
SGTC_1424 4048-1941 275 µM 3.0664179863319 0.000390168777300272 yes 13 0.00108320115606956 12 X1424
SGTC_2980 9014342 25.29 µM 3.05093473143401 0.00041509069497256 yes 14 0.00114065079856151 32 2996599
SGTC_641 4092-0595 30 µM 3.02981403939531 0.000451472129459268 yes 15 0.00122352178253005 22 786260
SGTC_599 1935-0052 86.5 µM 2.97020457261672 0.000570702199476 yes 16 0.00148800747620792 11 9557311
SGTC_3269 9137823 49.47 µM 2.96011626836773 0.00059355238588957 yes 17 0.00153761479537971 9 17682936
SGTC_3349 9149703 23.001 µM 2.95331230669437 0.000609437637378706 yes 18 0.00157191862614851 5 4910494
SGTC_2986 9022445 71.43 µM 2.92236231112632 0.000686774180606414 yes 19 0.00173693589189849 16 6459286
SGTC_1070 indatraline 8.81 µM 2.90706562713152 0.000728251093278698 yes 20 0.00182418323713486 19 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_549 1661-1316 519 µM 2.90668681656403 0.000729306932735642 yes 21 0.00182639354781522 20 2857282
SGTC_1264 0783-0040 158 µM 2.8849670649232 0.000792258576586753 yes 22 0.0019572730592103 13 2855798
SGTC_987 1497-1013 404 µM 2.85205859272439 0.000897220321403607 yes 23 0.00217185466005756 14 1676435
SGTC_167 3672-0051 66.205 µM 2.82381688476518 0.000997332062633293 yes 24 0.00237277444203796 26 3237971
SGTC_2292 7671323 168.05 µM 2.82191508369195 0.00100442889686609 no 25 0.0023868907819289 30 937504
SGTC_1396 3511-0007 98.6 µM 2.81256402582468 0.00104000258484151 no 26 0.00245741189511109 20 X1396
SGTC_1240 0356-0016 42.1 µM 2.79900357544338 0.0010936457938702 no 27 0.0025630284922239 17 4305613
SGTC_1013 4112-3890 241 µM 2.76116903680198 0.00125700181702211 no 28 0.00287974291406131 20 705171
SGTC_152 4469-0003 551.229 µM 2.74432701408148 0.00133666063123683 no 29 0.00303175510991837 43 697280
SGTC_1177 0983-0204 23.6 µM 2.74190653377768 0.00134848068812248 no 30 0.00305418601084688 31 766818
SGTC_2786 7743617 45.45 µM 2.72093100636297 0.00145498271959911 no 31 0.00325491733663298 16 583674
SGTC_960 1222-0186 7.7 µM 2.6805351346516 0.00168199001987304 no 32 0.00367522738549209 29 3126296
SGTC_593 1203-0218 61.7 µM 2.66849366085461 0.00175564479253385 no 33 0.00380961081496638 21 3666956
SGTC_1123 mangostin 811.285 nM 2.66378909341743 0.00178521013213607 no 34 0.00386329944723043 6 5281650 An antioxidant.
SGTC_2429 5902844 64.44 µM 2.65188936651572 0.00186202513138195 no 35 0.00400213821123041 28 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1892 st058411 7.36 µM 2.63184785412235 0.00199821452077877 no 36 0.00424609416180524 22 3934738
SGTC_2862 9027634 71.43 µM 2.63061898478115 0.00200685230634344 no 37 0.0042614764537871 21 5012562
SGTC_1036 k216-0215 33.5 µM 2.61586383828551 0.00211324671998807 no 38 0.00445010208859819 13 622330
SGTC_3168 9103419 49.47 µM 2.61268173767086 0.0021368519827792 no 39 0.00449174577006946 8 16649256
SGTC_1353 1498-1206 8.11 µM 2.60830375677213 0.00216971926834417 no 40 0.00454960846260811 28 6756808
SGTC_888 0916-0002 6.97 µM 2.60795661055457 0.00217234494708905 no 41 0.0045542249588857 20 2802138 YIL048W NEO1
SGTC_1257 0669-0121 16 µM 2.59301514514379 0.00228812333762585 no 42 0.00475692904430841 19 4307855
SGTC_2873 9040596 71.43 µM 2.58533857943072 0.00234975554883488 no 43 0.00486417068507263 37 6463863
SGTC_1329 1447-1697 50.6 µM 2.5789375027958 0.00240229213203364 no 44 0.00495523574452965 15 2840515
SGTC_2151 5563267 85.4165 µM 2.56170912892378 0.00254901494029283 no 45 0.00520792557660977 35 5310824
SGTC_1524 corynanthine 62.1 µM 2.55808172707268 0.00258092080462084 no 46 0.00526256764872657 35 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_1125 tnp00248 1.32998 µM 2.55045327442249 0.00264919944455351 no 47 0.00537914720593614 36 24207736
SGTC_2239 6685329 187.64 µM 2.53340878917312 0.00280768667960763 no 48 0.00564795668527477 26 805680
SGTC_3340 9146634 11.102 µM 2.52864254938854 0.00285351025460275 no 49 0.00572522887208888 16 4907387
SGTC_395 anisomycin 6.25 µM 2.5201329352411 0.00293700345496575 no 50 0.00586552604260747 26 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_3322 9139058 2.11 µM 2.51822941894317 0.00295597881926695 no 51 0.00589732341032901 33 4908926 YPR165W RHO1
SGTC_2382 9035899 200 µM 2.51667322191822 0.00297157391396473 no 52 0.00592343245385229 29 6462679
SGTC_2834 9001755 58.44 µM 2.49515042807134 0.00319499515884091 no 53 0.00629518712820195 27 2989575
SGTC_1035 k081-0041 55.2 µM 2.46791424852995 0.0034993396798414 no 54 0.00679514358496599 29 731709
SGTC_1402 3909-7673 35.9 µM 2.45972717269921 0.00359578252800918 no 55 0.00695213348184796 24 5328014
SGTC_2362 9071156 126 µM 2.43143699369226 0.0039476702740047 no 56 0.00751953186988583 27 653133
SGTC_1409 3909-8004 61.9 µM 2.4229158587517 0.0040595444676662 no 57 0.00769824615935947 28 2119279
SGTC_690 glyoxal 20.3 µM 2.41848583060742 0.00411882050169258 no 58 0.00779262627080602 60 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_2206 7254556 146.969 µM 2.41225702116793 0.00420347518793913 no 59 0.00792705043582704 16 4398905
SGTC_718 1130-0073 349 µM 2.39367120898442 0.00446539710633436 no 60 0.00834034711799968 27 6740020
SGTC_1906 st060206 94.7 µM 2.39278083233717 0.00447830297964738 no 61 0.00836061304093445 20 5133468
SGTC_2284 7945075 39.21 µM 2.39256769063103 0.00448139737351181 no 62 0.00836547078257316 24 1245402
SGTC_456 gingerol 170 µM 2.37581138439285 0.00473072312715452 no 63 0.00875520552109577 22 442793 A herb.
SGTC_3336 9143619 71.43 µM 2.3609364603795 0.004962343549946 no 64 0.00911442679606531 10 45595730
SGTC_914 3820-6779 408 µM 2.35930466703933 0.00498835764544481 no 65 0.00915460852281972 27 2893481
SGTC_2162 5663267 200 µM 2.35576574267905 0.00504519307448165 no 66 0.00924228519173949 38 6456493
SGTC_597 k018-0003 82.8 µM 2.34691772944771 0.00518982378664303 no 67 0.00946471697862862 26 6786234
SGTC_3074 9116018 49.47 µM 2.34661403519866 0.00519485284794513 no 68 0.00947243399544388 27 17027303
SGTC_2016 5121758 140 µM 2.3095684355905 0.00584181204734874 no 69 0.0104560293974947 62 2795203
SGTC_3164 9100705 49.47 µM 2.3085051532981 0.00586139242397712 no 70 0.0104855282721953 21 17174235
SGTC_2777 climbazole 1.536 µM 2.29657341154949 0.00608514051886246 no 71 0.0108215584302488 38 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_12 0849-0099 9.267 µM 2.29445929023495 0.00612556517421978 no 72 0.0108820654359055 32 6071388
SGTC_1920 st075728 45.7 µM 2.27627163566014 0.00648328037228153 no 73 0.0114148783420686 35 3400306
SGTC_2064 5220758 200 µM 2.27043510682021 0.00660192676776152 no 74 0.0115905982209888 61 788518
SGTC_328 k915-0120 63.5 µM 2.27035714755403 0.00660352445073219 no 75 0.0115929611421706 17 6624543
SGTC_1155 4088-0394 48.2 µM 2.27030316482314 0.0066046309632695 no 76 0.0115945975870875 37 2326248
SGTC_3181 9108277 49.47 µM 2.25620673313331 0.00689924403563984 no 77 0.0120288435410819 44 17097298
SGTC_2641 levomentholum 100 µM 2.23842359868353 0.00728742389494029 no 78 0.0125967222715308 19 16666
SGTC_1301 naphtanilide LB 4.81 µM 2.23534384521173 0.00735657223413031 no 79 0.012697391833284 54 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_155 k072-0202 43.6 µM 2.22045821237664 0.00769900885493434 no 80 0.0131938396373874 39 5857737
SGTC_2963 9082507 9 µM 2.21831887812526 0.00774935907198553 no 81 0.0132665489461721 46 16459611
SGTC_596 1155-0152 116 µM 2.19862630914537 0.00822661089165346 no 82 0.0139522523317858 41 280313
SGTC_1855 st056195 39.6 µM 2.15791172899564 0.00929587036632827 no 83 0.0154673477042024 38 4028379
SGTC_1398 3558-0053 112 µM 2.1548541501348 0.00938087134144437 no 84 0.0155866246252581 20 4532369
SGTC_1081 sertraline 6 µM 2.15068949892859 0.00949774233976414 no 85 0.0157503578845825 41 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_1423 4048-0112 5.59 µM 2.14235506356256 0.00973545699018516 no 86 0.0160824605008989 43 X1423
SGTC_303 1348-1668 34.2 µM 2.13445165788517 0.00996566289382454 no 87 0.0164029134121616 44 5380509
SGTC_1780 st038448 24.544 µM 2.1312239668465 0.0100610352893833 no 88 0.016535347722612 49 728868 YDL195W SEC31
SGTC_858 0438-0351 2.77 µM 2.12906238770852 0.0101253504719652 no 89 0.0166245495471297 48 2799119
SGTC_2924 9010168 62.78 µM 2.12179613345053 0.0103441859696826 no 90 0.0169274307439951 38 2993929
SGTC_3188 9110789 49.47 µM 2.12079902011329 0.0103745351800843 no 91 0.0169693596030008 52 849217
SGTC_2560 caryophyllene 100 µM 2.1072776941479 0.0107938119778624 no 92 0.0175467578464422 46 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_651 3253-0966 34.4 µM 2.10337900707264 0.0109174121808137 no 93 0.0177163260177795 45 781462
SGTC_413 propylparaben 100 µM 2.10188948547428 0.0109649586763396 no 94 0.0177814789082327 40 7175 A pharmaceutical preservative.
SGTC_1403 3909-7815 62.9 µM 2.0901600832805 0.0113457047546168 no 95 0.018301710950269 37 6615483
SGTC_1318 1280-3875 124 µM 2.07703785808789 0.0117852306044237 no 96 0.0188990326063889 48 373245
SGTC_1946 st076057 65.1 µM 2.07252758250918 0.011939676246171 no 97 0.0191081333440525 27 953009
SGTC_2819 7996655 46.38 µM 2.06869043762886 0.0120724508906343 no 98 0.0192875725554807 27 6456960
SGTC_1838 st055369 84.5 µM 2.05211548145741 0.012660796907836 no 99 0.0200792203646587 42 676036
SGTC_333 3486-0131 40.1 µM 2.05146818902055 0.0126842681749861 no 100 0.0201106872217659 41 6744690
SGTC_754 3474-0146 171 µM 2.05056928508058 0.012716925496072 no 101 0.0201544550407771 46 24762078
SGTC_2288 7946289 167.31 µM 2.0403155793213 0.0130946224789395 no 102 0.0206594520461554 46 1246052
SGTC_1316 1272-0050 65.9 µM 2.03853071795138 0.0131613494381555 no 103 0.0207484429823326 35 7340392
SGTC_13 0199-0087 65 µM 2.02307557382342 0.0137515283641072 no 104 0.0215326782260325 58 4589825
SGTC_3100 9120536 49.47 µM 2.00798939596835 0.0143494962384818 no 105 0.0223222092571749 47 16421196
SGTC_2442 5158906 48.48 µM 2.00376905727218 0.0145207334131093 no 106 0.022547402443195 34 1893835
SGTC_225 nsc-122657 1.016 µM 1.98878927022505 0.0151428018000146 no 107 0.0233622338001519 46 275685
SGTC_2804 7954240 19.48 µM 1.98701364833908 0.0152180346854603 no 108 0.0234604421997666 61 828705
SGTC_1924 st058459 75.1 µM 1.98566018982325 0.0152755959990188 no 109 0.02353553412048 35 688683
SGTC_986 1493-0483 84 µM 1.97682063902832 0.0156561518109044 no 110 0.0240309539483387 50 40079
SGTC_517 1365-0151 113 µM 1.97561742642693 0.0157085756643049 no 111 0.0240990617137212 53 768657
SGTC_136 0097-0015 404.482 µM 1.97415786596091 0.0157723706341127 no 112 0.0241818976297152 56 4861337
SGTC_2883 9059145 45.46 µM 1.94656956611843 0.0170206657218702 no 113 0.0257931801153023 60 16476510
SGTC_622 1348-1566 26.3 µM 1.94605674612299 0.0170446469006999 no 114 0.0258239617717912 55 7340407
SGTC_2384 9036245 200 µM 1.94172337643821 0.0172484453494027 no 115 0.0260852985967159 40 6462766
SGTC_2338 7999974 200 µM 1.93431342863202 0.0176017593508517 no 116 0.0265373015809273 60 315925
SGTC_1587 estradiol valerate 56.1 µM 1.93095591487191 0.0177638716284653 no 117 0.0267442522375307 51 13791 A steroid.
SGTC_2823 7987624 58.44 µM 1.92062451018622 0.0182707204076101 no 118 0.0273895314276101 79 2239440
SGTC_2191 5911152 200 µM 1.91132804143444 0.0187372779008876 no 119 0.0279812188206402 43 2875902
SGTC_821 1114-0266 29.2 µM 1.89496407229008 0.0195831695732157 no 120 0.0290485808147971 52 3123235
SGTC_101 0490-5701 117.494 µM 1.8891122999767 0.0198934323490857 no 121 0.0294383913261253 39 4661669
SGTC_1950 st077106 7.18 µM 1.87408373373084 0.0207094197862005 no 122 0.0304594424715479 61 13831864
SGTC_1862 st057513 3.81 µM 1.87209055914864 0.0208197405986094 no 123 0.030597037950294 64 5393163
SGTC_3102 9121669 49.47 µM 1.85592935143157 0.0217327589319822 no 124 0.0317318143471727 54 41905072
SGTC_2937 9044753 11.33 µM 1.84970007078915 0.0220935988818606 no 125 0.0321783951538584 66 6465530 YGL099W LSG1
SGTC_1172 0370-0043 85 µM 1.84942845605029 0.0221094469270664 no 126 0.0321979848192838 56 376585
SGTC_778 3456-2434 196 µM 1.84894537970014 0.0221376569394396 no 127 0.0322328500499878 57 5539063
SGTC_1875 nocodazole 6 µM 1.84652256002436 0.0222795999924156 no 128 0.0324081833864173 72 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_1376 2910-0861 41.3 µM 1.83822735962712 0.0227714098249091 no 129 0.0330144549111985 57 1112859
SGTC_3277 9138724 49.47 µM 1.83727776528984 0.0228282890432136 no 130 0.0330844502881079 56 15943418
SGTC_3234 9132280 49.47 µM 1.82975591683315 0.023283079416259 no 131 0.0336432226818558 59 17612295
SGTC_3178 9107506 49.47 µM 1.82926031473443 0.0233133107159553 no 132 0.0336803103642073 86 8897194
SGTC_2249 haloperidol 116.36 µM 1.81837385410211 0.0239857543902167 no 133 0.0345035058723121 114 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1719 st032227 49.2 µM 1.81715667162526 0.0240619413969064 no 134 0.0345965636304144 76 3125804
SGTC_1685 st024049 53.0905 µM 1.81279559153896 0.0243365854223743 no 135 0.0349316770825474 60 1941139
SGTC_3073 9114972 49.47 µM 1.80262740278436 0.024987175128052 no 136 0.0357233752237323 54 41905075
SGTC_683 panaxydol 45 µM 1.80119137695484 0.0250802207256616 no 137 0.0358363605180862 47 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_769 0302-0231 76 µM 1.79887499848993 0.0252309197212882 no 138 0.0360192281316104 96 571869 YER009W NTF2
SGTC_1616 st002734 56.1 µM 1.79846190110009 0.0252578745843651 no 139 0.036051920470393 68 4026101
SGTC_3260 9137109 49.47 µM 1.7977349094843 0.0253053698368082 no 140 0.0361095132682835 43 17478346
SGTC_1916 st067606 49.2 µM 1.79704728030439 0.0253503623279297 no 141 0.0361640570572691 82 19590279
SGTC_2167 5876490 200 µM 1.79640354299267 0.025392543630804 no 142 0.0362151803972828 55 686534
SGTC_310 1273-0058 1.06 µM 1.79442542673306 0.0255225290324266 no 143 0.0363726457623718 48 2734232
SGTC_1903 st060211 78.3 µM 1.78363683200257 0.0262413104721192 no 144 0.0372413482977943 66 688960
SGTC_1550 gossypolone 36.6 µM 1.77951329909975 0.0265204718791659 no 145 0.0375778232551981 67 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1346 1488-2224 62.4 µM 1.77674490121789 0.0267092799643138 no 146 0.03780511051032 83 3722427
SGTC_187 1488-2104 32.728 µM 1.77001078128226 0.0271732460519157 no 147 0.0383626723640905 63 2852859
SGTC_569 4130-2812 160 µM 1.76607812962391 0.0274472937930602 no 148 0.0386913710353094 65 743552
SGTC_2038 4100038 30.985 µM 1.76574689667668 0.0274704806925129 no 149 0.0387191605802958 81 3596803
SGTC_555 4296-0685 37 µM 1.76474059485844 0.027541023821149 no 150 0.0388036863232983 76 2908540 YHR072W ERG7
SGTC_981 1488-1094 54.9 µM 1.76007704687166 0.0278699194180438 no 151 0.0391973719769003 50 3449522
SGTC_1140 3229-1848 2.98 µM 1.75621070594504 0.0281450670280389 no 152 0.0395262186707156 54 2849525
SGTC_2389 9091542 195.52 µM 1.75469067595185 0.0282538573248313 no 153 0.0396561158811883 82 3626624 YOL127W RPL25
SGTC_2196 6573537 42.6665 µM 1.75335983768221 0.0283493941192034 no 154 0.0397701301516291 64 2903087
SGTC_783 0848-0141 92.7 µM 1.75154653103559 0.0284799983902631 no 155 0.0399259067630624 83 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_1145 3546-0597 10.2 µM 1.74797231709796 0.0287388987976197 no 156 0.0402344105431862 67 875334
SGTC_2640 pentamidine 10.38 µM 1.74467547005209 0.0289794401230963 no 157 0.0405206877724738 87 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1529 apigenin 74 µM 1.74309638518852 0.0290952430372332 no 158 0.0406583899711197 64 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1407 3909-7909 12.3 µM 1.7311866182153 0.0299810928936954 no 159 0.0417092426506075 46 4411780
SGTC_2289 7946404 165.07 µM 1.72776878645246 0.030239403310882 no 160 0.0420148427907936 94 1246120 YPR165W RHO1
SGTC_1362 1611-0397 101 µM 1.72532028273758 0.0304255864052529 no 161 0.0422348843282204 76 27816
SGTC_308 4092-1169 104 µM 1.724601420732 0.0304804283455652 no 162 0.0422996636181961 68 2268590 YDL196W YDL196W
SGTC_2065 5221596 34.26 µM 1.72040397206193 0.0308022888294666 no 163 0.0426795177447133 74 788581
SGTC_2133 5320837 200 µM 1.7193462813527 0.0308838349125352 no 164 0.0427756687153184 57 2841355
SGTC_3310 9130229 44.1445 µM 1.71375004426489 0.0313182740692954 no 165 0.0432873208202273 69 7761258
SGTC_1834 st055981 52.8 µM 1.70813612858987 0.0317591509859614 no 166 0.0438055432812621 77 471719 YDL150W RPC53
SGTC_164 4100-3994 89.624 µM 1.70563740414681 0.0319570255353846 no 167 0.0440378053651168 84 4615967
SGTC_1497 4476-2978 41.3 µM 1.70420333748774 0.0320710487097251 no 168 0.0441715529594819 78 1528379
SGTC_1938 st074717 56.4 µM 1.70373363186294 0.0321084681275734 no 169 0.0442154309725865 59 17250979
SGTC_372 0155-0182 15.9 µM 1.70164524139889 0.0322752778335433 no 170 0.0444109455787531 64 771486
SGTC_3276 9139060 49.47 µM 1.70072170573659 0.0323492727734667 no 171 0.0444976286271183 98 4870619
SGTC_2147 5545932 89.7195 µM 1.69989956969177 0.0324152611587123 no 172 0.044574908942715 90 797404
SGTC_2468 5987765 72.9 µM 1.69866930762824 0.0325142150084881 no 173 0.0446907547743528 65 26772094
SGTC_2871 9038510 12.99 µM 1.69605567195832 0.0327252650618309 no 174 0.0449376687006382 101 4945164
SGTC_843 0310-0051 143 µM 1.68245002864548 0.0338422356086049 no 175 0.0462408036009676 76 2065037
SGTC_193 1273-0060 1.558 µM 1.67294405114093 0.034641103196771 no 176 0.0471691553595236 80 2847393 YHR072W ERG7
SGTC_7 0192-1582 4.227 µM 1.66866222403194 0.0350059672039481 no 177 0.0475921698205296 104 252616
SGTC_936 3005-4620 401 µM 1.66124229136036 0.0356457012801276 no 178 0.04833239747781 79 777207
SGTC_1121 fusaric acid 630.51 nM 1.66097868331864 0.035668604231807 no 179 0.0483588640035732 70 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_761 k216-0224 480 µM 1.65496648362907 0.0361942425267162 no 180 0.0489656483938515 90 1340404
SGTC_1887 st057648 70.8 µM 1.64674936651033 0.0369228943406952 no 181 0.0498047863208295 100 688672
SGTC_2479 5617353 43.85 µM 1.64003126747688 0.0375274929914595 no 182 0.0504993329563014 92 2731746
SGTC_3115 9123671 49.47 µM 1.63683631670525 0.0378178477308288 no 183 0.0508323376204894 64 3286988
SGTC_3230 9131665 49.47 µM 1.63570791757206 0.0379208328838467 no 184 0.0509503658166077 40 15943720
SGTC_2772 vinpocetine 57.06 µM 1.63520328179017 0.0379669632696549 no 185 0.0510032202143375 77 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1294 1000-1494 117 µM 1.63260394655184 0.03820530270231 no 186 0.0512761603370452 79 712797 YDL207W GLE1
SGTC_249 wiskostatin 11.211 µM 1.63002757831284 0.0384427388306941 no 187 0.0515478342220482 70 2775510 A n-wasp and actin depolymerizer.
SGTC_305 1682-2595 20.8 µM 1.62854018162143 0.0385803629198308 no 188 0.0517051981794387 83 226033
SGTC_2431 5490079 200 µM 1.62601170191725 0.0388152362852973 no 189 0.0519735830150097 112 5722345
SGTC_2659 sanguinarine 24.21 µM 1.62319197186981 0.0390785364735698 no 190 0.0522741867424233 78 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2703 st077852 53.4 µM 1.61950545242285 0.0394249668137617 no 191 0.0526692771499494 84 6281836
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.61775055223388 0.0395907542122549 no 192 0.0528581833567576 89 688664
SGTC_1187 1391-0724 117 µM 1.61034316872726 0.0402967961035395 no 193 0.0536614799928038 79 6997986
SGTC_1181 1222-0449 220 µM 1.6058337145536 0.0407316037721794 no 194 0.0541552253889313 84 658318
SGTC_2399 5884133 200 µM 1.60532288091744 0.0407810982082498 no 195 0.054211383134777 99 722445
SGTC_739 1486-1183 203 µM 1.59741843379101 0.0415531945202484 no 196 0.0550862330583814 68 4346692
SGTC_2201 6605497 169.863 µM 1.59604201474413 0.041688844395105 no 197 0.0552397066324938 74 670741
SGTC_1799 st045822 46.1415 µM 1.59440831182495 0.04185031558084 no 198 0.0554223059854544 90 3674992
SGTC_2764 methyldopa 94.69 µM 1.59014359644494 0.0422742169801754 no 199 0.0559012204435335 75 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_147 4466-0538 29.23 µM 1.58673084926875 0.0426159315188168 no 200 0.0562868081458613 89 6742687 YHR072W ERG7
SGTC_3215 9129942 49.47 µM 1.58572159141743 0.0427174141753392 no 201 0.0564012395163776 94 17682944
SGTC_110 0850-0284 111.64 µM 1.5842851735266 0.0428621853142214 no 202 0.05656441911939 58 3906265
SGTC_1460 k062-0059 9.15 µM 1.5836215400602 0.0429292042101353 no 203 0.0566399345764721 78 1373085
SGTC_3021 9087658 49.47 µM 1.58292425181927 0.0429997130289502 no 204 0.0567193651885253 53 25237042
SGTC_2998 9066762 71.4286 µM 1.58286461324275 0.0430057479400291 no 205 0.056726162904682 82 4945196
SGTC_1250 0485-0349 40.2 µM 1.5827002464049 0.043022383992561 no 206 0.0567449010650224 86 6842794 YDL195W SEC31
SGTC_2981 9013952 38.96 µM 1.57976045563533 0.0433208079385548 no 207 0.0570808674084385 79 2996344
SGTC_337 1315-0038 354 µM 1.57920234484507 0.0433776512045716 no 208 0.0571448261511827 67 1626437
SGTC_2060 5238662 140 µM 1.57684079042136 0.0436188409990582 no 209 0.057416081633084 72 790130
SGTC_3030 9087619 49.47 µM 1.57641368419673 0.0436625774741844 no 210 0.0574652483794096 105 25236973
SGTC_2395 5646831 180.19 µM 1.57290568853816 0.0440231431803553 no 211 0.0578703288650798 95 6808628
SGTC_1192 1488-0095 21.4 µM 1.57188226690515 0.0441287857461914 no 212 0.0579889289206346 74 915875
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 1.55795550750639 0.0455867868316143 no 213 0.0596218977741923 91 688761
SGTC_116 0155-0182 31.788 µM 1.55152648400243 0.0462727883711295 no 214 0.0603877828030635 89 771486
SGTC_1364 1653-0028 37.6 µM 1.55113182701244 0.0463151683796553 no 215 0.0604350476776012 74 5718652
SGTC_2471 5466956 24.79 µM 1.54791705870521 0.046661546337094 no 216 0.0608211334829783 117 724419
SGTC_2076 5212012 200 µM 1.54598329186167 0.0468709008988006 no 217 0.061054301517906 78 604802
SGTC_2160 5660466 132.927 µM 1.54512418277377 0.0469641516366147 no 218 0.0611581143140472 105 2859134
SGTC_1022 4477-0945 21.3 µM 1.54397980462414 0.0470885975038698 no 219 0.0612966125764167 80 4648966
SGTC_746 1095-0025 46.6 µM 1.52546628288781 0.0491388272261606 no 220 0.0635714185945043 92 6749286
SGTC_3140 9094243 49.47 µM 1.52532848645486 0.0491543502263824 no 221 0.0635885930021778 101 19291112
SGTC_2612 dictamnine 15.46 µM 1.52531490210113 0.0491558807387614 no 222 0.0635902862983054 128 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1602 st001878 87.6 µM 1.52262685806085 0.0494594850703243 no 223 0.063926043179042 109 595405 YLR310C CDC25
SGTC_402 epigallocatechin gallate 10 µM 1.52237206973454 0.0494883399328168 no 224 0.0639579395509211 102 65064 An antioxidant.
SGTC_2376 9072922 81.32 µM 1.52101322784853 0.0496424562160316 no 225 0.0641282589293006 91 17087968
SGTC_2948 9070189 9.45 µM 1.51985714731786 0.0497738771434838 no 226 0.0642734412983941 78 6473636 YDL196W YDL196W
SGTC_2966 9084041 48.03 µM 1.51466183730893 0.0503678993444883 no 227 0.0649290317771912 85 17741380
SGTC_1378 2093-0007 380 nM 1.51373914750747 0.0504739863740257 no 228 0.065046005936364 106 3618014
SGTC_1778 st046819 58.9 µM 1.51189722635995 0.0506862951596401 no 229 0.0652800048852535 112 671715
SGTC_1565 sinapyl alcohol 95.1 µM 1.50439624760111 0.0515582496451944 no 230 0.066239684943968 99 5280507 A phenol propionate derived from cinnamic acid.
SGTC_71 0417-1750 47.813 µM 1.50392436135312 0.0516135005930931 no 231 0.066300421777348 91 6811472
SGTC_573 3702-0553 84.7 µM 1.5026359014439 0.0517646000859068 no 232 0.0664664800708717 103 1222756
SGTC_2694 st077685 81.9 µM 1.4997012708152 0.0521100607060788 no 233 0.0668459006238753 78 2838096
SGTC_2323 6148992 148.28 µM 1.49397134805506 0.0527898561912848 no 234 0.0675915541312 90 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2045 5106652 78.05 µM 1.4811357216537 0.0543382002451669 no 235 0.0692852052943531 76 673349
SGTC_649 1123-0311 367 µM 1.48014440448875 0.0544592605624841 no 236 0.0694173567354396 105 693629 YIL048W NEO1
SGTC_2241 6772625 37.8075 µM 1.47904272293967 0.0545940488209697 no 237 0.0695644483973064 104 2285411
SGTC_1759 st043059 70 µM 1.47696777719422 0.0548486299635736 no 238 0.0698421375147098 111 669426
SGTC_1500 4488-1866 171 µM 1.47626892276338 0.0549345853767598 no 239 0.0699358567151439 95 2900003
SGTC_3141 9094609 49.47 µM 1.47574306009612 0.0549993338746489 no 240 0.0700064408024467 129 25236309 YDL196W YDL196W
SGTC_2774 tamoxifen 10.92 µM 1.4719291173098 0.0554707439919738 no 241 0.0705200098855692 90 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_686 1319-0111 510 µM 1.47054909046939 0.0556421016354975 no 242 0.0707065502293683 114 4562600
SGTC_2915 7971052 15.16 µM 1.46895473712972 0.0558405920190741 no 243 0.0709225332397509 76 5741558
SGTC_2159 5658611 73.75 µM 1.46793638576024 0.0559676646318581 no 244 0.0710607517205632 90 793844
SGTC_1040 k898-0338 155 µM 1.45767396555332 0.0572610040215018 no 245 0.0724652156386536 96 20969351
SGTC_174 3553-0389 74.3 µM 1.45685006903637 0.0573658486229159 no 246 0.0725788857099419 94 738071
SGTC_545 4218-0007 221 µM 1.45515038488272 0.0575826183829062 no 247 0.0728138165074205 112 2840508
SGTC_1953 st076800 12.1 µM 1.44665873363914 0.0586752682196899 no 248 0.073996263768954 121 297591
SGTC_2369 9071472 200 µM 1.44486781215464 0.058907777235367 no 249 0.0742475094964033 82 17296037
SGTC_645 0845-0943 5.41 µM 1.43700046347483 0.0599377410415729 no 250 0.0753589309266992 99 1885106
SGTC_3198 9112019 49.47 µM 1.43640966018703 0.0600156526009131 no 251 0.0754429029662184 113 45595555
SGTC_2503 beta-caryophyllene alcohol 24.72 µM 1.43546552007432 0.0601403246907787 no 252 0.0755772434773341 96 61125 An anti-inflammatory.
SGTC_2370 9071495 200 µM 1.43214291256778 0.0605806822561951 no 253 0.0760514627589974 115 21791103
SGTC_1005 4092-0690 4.4 µM 1.43143671283642 0.0606746017782463 no 254 0.0761525464257724 128 1529343
SGTC_1822 st052468 42 µM 1.430133499578 0.0608482187998366 no 255 0.0763393535683955 94 2873678
SGTC_876 0720-0963 56.8 µM 1.42929635398793 0.0609599499851335 no 256 0.0764595367520703 99 765861
SGTC_609 0986-0026 86.3 µM 1.42221813843694 0.0619110790863385 no 257 0.0774814673642488 106 2848610
SGTC_3295 9122362 53.5725 µM 1.41418767635337 0.0630041459554641 no 258 0.0786534026958761 119 4730473
SGTC_1741 st038134 10.228 µM 1.41271760445397 0.0632058629384581 no 259 0.0788693866164331 95 1272587
SGTC_1317 1273-0028 910 nM 1.41230868262443 0.0632620627470872 no 260 0.0789295454803655 124 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_1563 conessine 56.1 µM 1.41216121701683 0.0632823390942329 no 261 0.0789512485274795 71 441082 An anti-amoebic, histamine inhibitor.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM 1.41106167460717 0.0634336844289798 no 262 0.0791132146933632 128 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_934 2950-0684 338 µM 1.40699756399658 0.0639955307040466 no 263 0.0797140555590692 120 1121253
SGTC_2404 5161160 200 µM 1.4061870842317 0.0641080375292328 no 264 0.0798342892033087 140 2831543
SGTC_1935 st074532 41.6 µM 1.40530956879765 0.0642300232229695 no 265 0.079964622092453 116 2829742
SGTC_286 k060-0067 22.9 µM 1.40365785795805 0.0644601211206071 no 266 0.080210378597529 121 5985051
SGTC_2152 5568786 200 µM 1.40218280242653 0.0646661502603881 no 267 0.0804303328859141 111 5399883
SGTC_2914 7968218 45.32 µM 1.40165453208469 0.0647400609466959 no 268 0.080509217142129 81 2977111
SGTC_1120 ficusin 1.78878 µM 1.40133824989893 0.0647843436017056 no 269 0.0805564741147558 101 6199 A DNA cross-linker.
SGTC_1134 3477-0009 42.5 µM 1.40084245329416 0.0648538073897361 no 270 0.0806305952087868 124 3973534
SGTC_1673 st016611 27.3 µM 1.39967363638605 0.0650177938091745 no 271 0.0808055359949631 124 5226799
SGTC_2177 5811945 192 µM 1.39939103741685 0.0650574910582777 no 272 0.080847876530396 112 5343475
SGTC_1375 2910-0797 186 µM 1.39819770335399 0.0652253285701237 no 273 0.081026853132055 100 742508
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM 1.39698556242379 0.0653961549293413 no 274 0.0812089563718559 111 756377
SGTC_3061 glucosamine 200 µM 1.39628155715074 0.0654955291933886 no 275 0.0813148626656705 93 91431 and experimental redox chemotherapeutic
SGTC_2906 7926292 26.41 µM 1.39428880087649 0.0657774527686438 no 276 0.0816152057032231 93 2966319
SGTC_1473 k844-0725 134 µM 1.39364885941898 0.0658681872285209 no 277 0.0817118332276616 132 54682906
SGTC_2250 alverine citrate 130 µM 1.38973102461095 0.066425795899259 no 278 0.0823052850610536 139 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_2785 7756463 72.73 µM 1.3887690491274 0.0665632670435826 no 279 0.0824514948696964 152 2201551
SGTC_723 4182-0001 115 µM 1.38847081501678 0.0666059308907306 no 280 0.0824968628962754 107 744821 YLR208W SEC13
SGTC_3195 9113082 49.47 µM 1.38621660559839 0.0669290914695255 no 281 0.0828403862089033 96 17018038
SGTC_1913 st060213 96.1 µM 1.38267499968569 0.0674392595412903 no 282 0.083382270452845 115 688959
SGTC_1603 st002045 67.8 µM 1.38000447686753 0.0678259317598355 no 283 0.0837926332110568 100 5887985
SGTC_980 1473-0395 201 µM 1.37409488870213 0.0686876821109171 no 284 0.0847061130268928 116 768876
SGTC_431 k089-0097 107 µM 1.37264203681007 0.0689008280517524 no 285 0.084931828401994 125 5499420
SGTC_3069 9117009 49.47 µM 1.36450676024889 0.0701037765693796 no 286 0.0862040640028445 91 41904981
SGTC_758 0868-0029 16 µM 1.35891051820915 0.0709406176867908 no 287 0.0870874727135683 103 762687
SGTC_3328 9140624 29.0385 µM 1.35786880653694 0.0710972350100422 no 288 0.0872526584878832 117 4904392
SGTC_2409 alverine citrate 63.97 µM 1.35595294431414 0.071385970537659 no 289 0.0875570701937236 95 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3339 9145883 14.936 µM 1.35172211881255 0.0720267766378299 no 290 0.088232113242013 98 2030670
SGTC_1222 0366-0074 1.18 µM 1.34477986968236 0.0730878010514033 no 291 0.0893481664513265 131 286520
SGTC_1828 st055811 49 µM 1.3410101766582 0.0736689342879136 no 292 0.0899585742596454 95 5877589
SGTC_988 1497-1057 103 µM 1.3347805602985 0.0746370205620426 no 293 0.0909740888677488 114 3533044
SGTC_323 4013-0906 34.3 µM 1.33056961015154 0.0752968842887906 no 294 0.0916653337768837 101 2910086
SGTC_2959 9079155 11 µM 1.33029484785454 0.0753400941174189 no 295 0.0917105720220278 133 16189457
SGTC_280 3448-3607 3.04 µM 1.33023698715191 0.0753491958497455 no 296 0.0917201006068007 90 626179
SGTC_1972 st070201 17.4 µM 1.32981376315344 0.0754157962561957 no 297 0.0917898200552278 118 2829099
SGTC_762 1165-0429 115 µM 1.32577031209724 0.0760543553625756 no 298 0.0924578947375368 134 5967793
SGTC_477 mead ethanolamide 10 µM 1.32132104018517 0.0767617510006216 no 299 0.0931971706828879 60 16061185
SGTC_421 streptovitacin 30 mM 1.32077847927159 0.0768483545960221 no 300 0.0932876187285084 120 91467 include heat shock
SGTC_3064 1327-0027 10 µM 1.32047693076633 0.0768965198855025 no 301 0.0933379166414988 86 16000455 YPR107C YTH1
SGTC_2430 5571206 200 µM 1.31850576312663 0.0772119330751896 no 302 0.0936671985458773 135 1731771
SGTC_3162 9099653 49.47 µM 1.31692947335788 0.0774648670660273 no 303 0.0939311330017881 93 25237511
SGTC_1666 st014829 29 µM 1.31508440107075 0.0777617290995937 no 304 0.0942407692380121 106 3858230
SGTC_1088 bifonazole 369 nM 1.31503341273125 0.077769945088594 no 305 0.0942493366737317 107 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_1347 1493-0251 600 nM 1.31479704484782 0.0778080407554894 no 306 0.0942890604480766 119 3986378
SGTC_887 0885-0007 9.62 µM 1.30752011552493 0.0789878134998301 no 307 0.0955180638753113 133 5719458
SGTC_2021 4019055 173 µM 1.30628033207337 0.0791901572790994 no 308 0.0957286215115847 166 44827708 YER133W GLC7
SGTC_1684 st024538 14.6195 µM 1.30575191962651 0.0792765181196866 no 309 0.0958184677316217 118 6732859
SGTC_1331 1472-0049 76.2 µM 1.30483671462577 0.0794262628783458 no 310 0.0959742272001442 139 24051409
SGTC_532 1548-0774 215 µM 1.30266123904141 0.0797830707328535 no 311 0.0963452203085026 136 5932993
SGTC_1929 genistein trimethyl ether 50.5 µM 1.30199201575287 0.0798930760215221 no 312 0.0964595575027269 125 136420
SGTC_3042 9091578 49.47 µM 1.30162140156297 0.0799540460061356 no 313 0.0965229200354049 108 25236497
SGTC_135 0933-0004 26.348 µM 1.29964149434086 0.0802803580134641 no 314 0.0968619355130591 138 21230617 YGL099W LSG1
SGTC_2842 9000675 19.48 µM 1.2988634581816 0.0804088626270933 no 315 0.0969953960707131 124 2989072
SGTC_2156 5649887 115 µM 1.29724952699686 0.0806759236171073 no 316 0.0972726723545336 137 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_1350 1495-0454 146 µM 1.29576477232087 0.0809222005487158 no 317 0.0975282690952734 127 1069057
SGTC_996 3970-0799 1.8 µM 1.29536751934712 0.0809881892162425 no 318 0.0975967386331198 153 6615648 YGL040C HEM2
SGTC_453 enantio-paf c16 10 µM 1.2942515496196 0.0811737830017828 no 319 0.0977892729973542 153 13871343 A lipid and platelet activating factor
SGTC_938 3126-1755 342 µM 1.29365082086915 0.0812738212900158 no 320 0.0978930298435469 112 1777771
SGTC_922 1866-0035 480 µM 1.2934868133485 0.0813011493264073 no 321 0.0979213709594672 145 3156169
SGTC_346 4513-0042 7.16 µM 1.29344175540715 0.0813086583973937 no 322 0.0979291581939351 139 2827372
SGTC_2644 guaiazulene 100 µM 1.29046282857685 0.0818062690227896 no 323 0.098445004952784 99 3515 A coloring agent.
SGTC_2472 5377652 49.4 µM 1.28777375838936 0.0822574290780469 no 324 0.0989123647648575 145 1610903
SGTC_574 1315-0397 40 µM 1.28741457863345 0.0823178322263472 no 325 0.0989749128157072 145 6794277
SGTC_937 3122-0005 46.7 µM 1.28619544032802 0.082523103440107 no 326 0.0991874309924566 124 759535
SGTC_2296 7971656 126.45 µM 1.28430469693119 0.082842217367407 no 327 0.0995176820206622 103 666570
SGTC_1511 0906-3109 28.5 µM 1.28188887655801 0.0832513020490328 no 328 0.0999408152740785 131 2882180
SGTC_674 0498-0004 451 µM 1.28175851148341 0.0832734206264858 no 329 0.0999636861488428 153 4231473
SGTC_1996 st072960 66.8 µM 1.27779420131195 0.0839481427391097 no 330 0.100660999766208 129 1719405
SGTC_1488 4013-0813 75.9 µM 1.27609540180646 0.0842385302385308 no 331 0.100960898431985 118 2910057
SGTC_452 diindolylmethane 8 µM 1.27396097594351 0.0846044502369434 no 332 0.101338623318507 113 3071 Inhibits expression of several cancer promoting factors.
SGTC_859 0439-0102 54.6 µM 1.27253033256215 0.0848503822761039 no 333 0.101592376942205 149 610143
SGTC_339 3091-4833 71.4 µM 1.26854428173811 0.0855384235267898 no 334 0.102301823805308 155 3240077
SGTC_1807 st050092 58.9 µM 1.26768620417236 0.0856870832362703 no 335 0.102455016695739 138 5008496
SGTC_3041 9091929 49.47 µM 1.2503522159717 0.0887317123132114 no 336 0.105585455902724 125 25236887
SGTC_1793 st048256 72.231 µM 1.24952536901631 0.0888789316179667 no 337 0.105736490300126 123 672022
SGTC_1306 1185-0270 9.02 µM 1.24946122876099 0.0888903593248211 no 338 0.105748212880047 139 1548076
SGTC_2034 5197015 53.07 µM 1.24881157308429 0.0890061684904713 no 339 0.105867000013522 136 780676
SGTC_224 benfluorex 43.875 µM 1.24564476534757 0.089572299580051 no 340 0.106447420015184 122 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_3011 9081274 71.4286 µM 1.24448150483769 0.0897809270492274 no 341 0.106661201098923 130 6625322
SGTC_3135 9127742 49.47 µM 1.24185375913628 0.0902535350082506 no 342 0.107145261818722 126 3643468
SGTC_1911 st060208 74.3 µM 1.23814601250463 0.0909235239209707 no 343 0.107830962707518 153 688783
SGTC_2551 apiole 73.87 µM 1.23660052448734 0.0912038801884261 no 344 0.108117712555283 111 10659 A possible DNA adduct former.
SGTC_884 0851-0618 334 µM 1.23653787099472 0.0912152592290471 no 345 0.108129348851583 141 9642473
SGTC_611 3453-1652 23.7 µM 1.23510916443648 0.0914750247156925 no 346 0.108394939561 155 1560575
SGTC_3018 9082602 49.47 µM 1.23217785623547 0.0920097069892871 no 347 0.108941326599146 147 17332089
SGTC_3226 9131256 49.47 µM 1.23190944015687 0.092058782565714 no 348 0.108991457319529 112 17178073
SGTC_3123 9126162 49.47 µM 1.23030502800376 0.0923525278106599 no 349 0.109291451093176 118 25239884
SGTC_2264 7948757 110.76 µM 1.22998051992369 0.0924120249074515 no 350 0.109352199829622 116 2971411
SGTC_2625 euphol 100 µM 1.2287206582276 0.0926432837035682 no 351 0.109588279018325 150 6708538 A triterpene alcohol.
SGTC_3342 9147791 14.508 µM 1.22517089660936 0.0932971757303426 no 352 0.110255418733632 129 1838168
SGTC_870 0573-2213 57.6 µM 1.2250270329936 0.0933237481740164 no 353 0.110282517642623 129 3916321
SGTC_1980 st071811 45.7 µM 1.22246947835635 0.0937970769910807 no 354 0.110765069584674 150 4974850
SGTC_2536 dehydroabietamide 32.04 µM 1.21567958344551 0.0950622822073508 no 355 0.112053502272603 121 3983547
SGTC_1654 st012436 41.8 µM 1.21326615533913 0.0955150066077325 no 356 0.11251403912221 115 4323132
SGTC_1718 roemerine 11.9335 µM 1.21239883155075 0.0956780910646189 no 357 0.112679873989584 155 235224 An aporphine alkaloid with mutagenic activity.
SGTC_2462 5162487 171.77 µM 1.21134534537566 0.0958764554154702 no 358 0.112881538327019 137 2259986
SGTC_1012 4112-3522 18 µM 1.20996230217782 0.0961373321356227 no 359 0.113146679318932 135 3112398
SGTC_3119 9125183 49.47 µM 1.19947412174424 0.0981326690335767 no 360 0.115171820668718 102 22695334
SGTC_1408 3909-7976 48.8 µM 1.19890693013074 0.0982414334665354 no 361 0.115282068374319 139 24152374
SGTC_2499 avocadenofuran 51.48 µM 1.19856470491097 0.0983071011322375 no 362 0.115348624577178 139 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_3025 9087895 49.47 µM 1.19803519635469 0.0984087688829944 no 363 0.115451657585922 141 17173641
SGTC_2953 9074162 66.49 µM 1.19673326969709 0.0986590713232959 no 364 0.115705267543651 133 16451992
SGTC_1196 1588-0294 184 µM 1.196318373615 0.0987389351682345 no 365 0.115786170675283 152 6144269
SGTC_2205 7238770 200 µM 1.1960027800328 0.0987997158306206 no 366 0.115847737099427 121 279867
SGTC_822 1487-0950 154 µM 1.19311014704924 0.0993580884818043 no 367 0.116413119024675 137 1958375
SGTC_2003 4023581 200 µM 1.19291604900206 0.0993956381716063 no 368 0.116451126572641 124 16641307
SGTC_3286 9117135 37.221 µM 1.19178512338163 0.0996146303450813 no 369 0.116672755223764 141 3438150
SGTC_2861 9024595 19.48 µM 1.18865428110268 0.100222724578022 no 370 0.117287869160228 99 16482810
SGTC_2669 eugenol 100 µM 1.18175472055763 0.10157236200508 no 371 0.118651519442962 100 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_2100 5377183 190 µM 1.18152280676922 0.101617955949222 no 372 0.11869754938436 154 2844202
SGTC_1569 carminic acid 40.6 µM 1.17050399100663 0.103801446754449 no 373 0.120899104502619 138 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2770 toltrazuril 17.5 µM 1.16984215328604 0.103933671874561 no 374 0.121032248250403 130 68591 Kills coccidiodes.
SGTC_2029 5175081 200 µM 1.16902415713915 0.104097263802939 no 375 0.121196949323228 133 1380876
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM 1.16669991606194 0.104563109922772 no 376 0.121665788370506 151 2333 A French combination drug.
SGTC_3148 9097893 49.47 µM 1.16578865207571 0.104746165487885 no 377 0.12184995321413 136 17174100
SGTC_2741 miltefosine 3.04 µM 1.16452275517533 0.105000845014118 no 378 0.122106113597517 103 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_1735 st034310 56.75 µM 1.16316369556113 0.105274766089217 no 379 0.122381546554012 158 871153
SGTC_799 1310-0557 151 µM 1.15985037671811 0.105944737714319 no 380 0.123054864713877 160 5354492
SGTC_1163 k060-0048 49.9 µM 1.15834675063832 0.106249793670165 no 381 0.12336128008867 142 6809982
SGTC_1760 st045453 10.4495 µM 1.15713711886244 0.106495664100066 no 382 0.123608171736746 160 3323419 YIL048W NEO1
SGTC_2103 5378138 10 µM 1.15606240508185 0.106714455395624 no 383 0.123827816083561 144 244142
SGTC_2662 daunorubicin 22.37 µM 1.15575741293407 0.106776605050785 no 384 0.12389019851202 161 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1372 2752-0194 270 µM 1.15547577323427 0.106834019261822 no 385 0.123947824013662 132 823334
SGTC_1661 st013063 9.66 µM 1.15447944194236 0.107037307099896 no 386 0.124151831087367 157 721395
SGTC_1867 st057372 64 µM 1.15399242483378 0.107136777772303 no 387 0.124251637299593 131 688837
SGTC_2933 9026794 32.47 µM 1.15381365822035 0.107173306629392 no 388 0.124288286678153 152 17586027
SGTC_1877 wortmannin 25 µM 1.15317496378079 0.107303889697185 no 389 0.124419288740257 152 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2514 salinomycin 42.74 µM 1.15270970360791 0.107399085775194 no 390 0.124514778614982 154 23682228 A polyether potassium ionophore.
SGTC_191 3914-0123 66.505 µM 1.14833226178445 0.108297728487019 no 391 0.125415712822752 161 3144412
SGTC_2349 9023730 187.07 µM 1.14831135439439 0.108302033499385 no 392 0.125420026724045 136 4126287
SGTC_2855 9016525 58.44 µM 1.14541615745791 0.108899369462238 no 393 0.126018404180969 162 43811474
SGTC_3249 9135183 49.47 µM 1.13689319119286 0.110671564508142 no 394 0.127791469415317 148 4902779
SGTC_496 calpeptin 138 µM 1.13457179629861 0.111157817839071 no 395 0.128277387915488 138 73364 A calpain inhibitor.
SGTC_2746 daunorubicin 9.88 µM 1.13030689371434 0.112055153203621 no 396 0.129173465379589 111 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2478 5763493 32.33 µM 1.12885031266735 0.112362800960199 no 397 0.129480492106052 163 1365576 YLR208W SEC13
SGTC_3194 9111903 49.47 µM 1.12466075585921 0.113251049764824 no 398 0.130366408763915 156 17087251
SGTC_535 2293-4129 48.2 µM 1.12108879205282 0.114012306383521 no 399 0.131125034485878 186 396118 YIL048W NEO1
SGTC_2889 9059656 51.95 µM 1.11811043857989 0.114649834336339 no 400 0.131759914363641 156 3949838
SGTC_2911 7942208 15.64 µM 1.11810926242634 0.114650086596597 no 401 0.131760165496305 142 1243384
SGTC_2150 5556613 200 µM 1.11793047186203 0.114688438014645 no 402 0.131798344752802 157 743190
SGTC_2063 5246145 200 µM 1.1158180208768 0.11514225992233 no 403 0.132250019180865 168 711240
SGTC_2463 5473429 200 µM 1.11459333894723 0.115405944631558 no 404 0.132512363036063 154 5399405
SGTC_2794 7785382 27.27 µM 1.11212531814875 0.115938634219651 no 405 0.133042136157754 160 2205081
SGTC_3126 9127922 49.47 µM 1.11212031660881 0.115939715505288 no 406 0.13304321124169 206 45595682
SGTC_2251 lansoprazole 556 µM 1.10862966792156 0.116696107765228 no 407 0.133794987041936 141 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1687 st020778 55.3625 µM 1.10678522006929 0.117097192934016 no 408 0.134193399921278 153 4259299
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.10478247726928 0.117533805166638 no 409 0.134626927522169 160 4213774
SGTC_2718 lomofungin 53.02 µM 1.09776676612301 0.119072366575039 no 410 0.136153173468597 154 5351222 A RNA synthesis inhibitor.
SGTC_2114 5491910 81.25 µM 1.09492663592472 0.11969923943113 no 411 0.136774389355091 152 2849228
SGTC_1308 1187-1617 41.4 µM 1.09110694340666 0.12054598577057 no 412 0.137612913972426 162 2882570
SGTC_568 1193-0097 7.48 µM 1.08976296745865 0.120844917994483 no 413 0.137908785375279 177 3646150
SGTC_1734 st037168 69.4 µM 1.08705585347645 0.12144862741696 no 414 0.138506063213611 156 708907
SGTC_1882 5615643 20 µM 1.08674837299837 0.121517332031056 no 415 0.138574014764541 153 2253075
SGTC_2305 7443522 69.23 µM 1.08424129623332 0.122078542476687 no 416 0.139128912986725 166 5415886
SGTC_2025 5147754 141 µM 1.08205573155691 0.122569265098002 no 417 0.139613882319222 155 315777 YLR208W SEC13
SGTC_1165 k072-0275 30.3 µM 1.08092595335731 0.122823474946472 no 418 0.139865026415599 162 6153523 YGL055W OLE1
SGTC_3187 9109394 49.47 µM 1.08040719069903 0.122940324802129 no 419 0.13998044758968 183 17098090
SGTC_1224 0823-0416 294 µM 1.07745454597631 0.123606884147111 no 420 0.140638623463437 158 3598164
SGTC_117 lucigenin 22.078 µM 1.0756451326351 0.124016607563537 no 421 0.14104299724862 167 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1754 st042065 16.137 µM 1.07499770078702 0.124163442588579 no 422 0.141187878859034 172 1126236 YIL048W NEO1
SGTC_2030 5175110 200 µM 1.0747200843414 0.124226442161152 no 423 0.141250034471363 161 2831986
SGTC_329 k048-0121 21.3 µM 1.07125677830455 0.125014250854918 no 424 0.142026994083175 167 6832902
SGTC_985 1493-0307 8.71 µM 1.07109893050819 0.12505023993508 no 425 0.142062474529026 172 3278274
SGTC_1050 3232-1156 69.3 µM 1.0700698232538 0.125285052355163 no 426 0.142293940525976 176 700529
SGTC_2136 5328288 199.296 µM 1.06628475448693 0.126151342736634 no 427 0.143147469530506 141 262395
SGTC_1804 st050076 49.1 µM 1.06521790256402 0.126396266131206 no 428 0.143388667003715 159 3895976
SGTC_3257 9139206 32.98 µM 1.0649284160101 0.126462782352334 no 429 0.143454162402984 171 4910041
SGTC_462 ag-879 158 µM 1.05962719592911 0.127685173795918 no 430 0.14465711802476 187 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_658 3253-0951 102 µM 1.05330501273291 0.129153693803866 no 431 0.146100611119369 182 1184878
SGTC_1677 st019204 53.9 µM 1.05293938220048 0.129238979369049 no 432 0.146184387543697 153 3945625
SGTC_1724 st037281 8.293 µM 1.05195764581352 0.129468168504134 no 433 0.146409491058245 174 574124 YDL195W SEC31
SGTC_2957 9076800 11.52 µM 1.05128299527424 0.129625830741822 no 434 0.14656431732935 153 16459615
SGTC_1895 st058434 18.3 µM 1.05091294708109 0.129712365489116 no 435 0.146649286733778 190 5393175
SGTC_464 bw-b 70c 158 µM 1.0480850601095 0.130374980149033 no 436 0.147299709447248 183 5353454
SGTC_2458 5808907 16.39 µM 1.04687843348658 0.130658421591066 no 437 0.147577824892429 194 2731747
SGTC_3089 9117425 49.47 µM 1.0462781706709 0.130799584308732 no 438 0.147716310441657 154 9401657
SGTC_2541 muurolladie-3-one 83.07 µM 1.04543046262958 0.13099911776705 no 439 0.147912031824026 204 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_347 4534-1311 26.2 µM 1.0446083515374 0.131192827002628 no 440 0.148102009054118 161 2862016
SGTC_3190 9110366 49.47 µM 1.04247917742343 0.131695431241951 no 441 0.148594787233805 151 17123768
SGTC_1703 st026983 48.3 µM 1.04244131875392 0.131704380012868 no 442 0.148603559189546 159 1104023
SGTC_3063 1327-0034 4 µM 1.04142993788318 0.13194359858061 no 443 0.148838027025527 179 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_327 1273-0057 3.96 µM 1.03753332091562 0.132868053157519 no 444 0.149743687515121 170 3108138
SGTC_1221 2958-7315 257 µM 1.03676058577345 0.1330519096757 no 445 0.149923724251465 176 4562705
SGTC_2676 harmalol 100 µM 1.0364575901472 0.13312404905896 no 446 0.149994357476056 176 5459187 A monoamine oxidase inhibitor
SGTC_3233 9132340 49.47 µM 1.03486732294851 0.133503112718891 no 447 0.150365438504057 204 17682950
SGTC_1851 st056236 18.9 µM 1.03313896510612 0.133915933417002 no 448 0.150769435417167 171 5393171
SGTC_492 tmb-8 126 µM 1.02658635315282 0.135488996917222 no 449 0.152307641365273 162 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_898 1000-0849 28.3 µM 1.0251637524873 0.135832182015179 no 450 0.152642964144943 205 6751807
SGTC_2172 5754775 163.918 µM 1.02477309724834 0.135926526925305 no 451 0.152735131569965 206 2263357
SGTC_792 4534-1957 155 µM 1.02376890769381 0.136169248856491 no 452 0.152972219718653 164 1717904
SGTC_2556 citropten 84.59 µM 1.02142322576203 0.136737377100293 no 453 0.153526983032083 154 2775 A potential DNA crosslinker.
SGTC_1824 st053723 68.6 µM 1.02013022899378 0.137051235034296 no 454 0.153833350968273 170 675225
SGTC_592 k241-0073 46.5 µM 1.01958212832135 0.137184427689457 no 455 0.153963342217378 180 4230158
SGTC_861 0443-0273 110 µM 1.01682825342466 0.137854978340772 no 456 0.154617569504735 184 6149169
SGTC_14 0354-0009 295 µM 1.01494181539524 0.138315602206133 no 457 0.155066781964132 190 1713507
SGTC_188 3229-0966 278.469 µM 1.01394232288017 0.138560079524149 no 458 0.155305137349896 211 5722370
SGTC_3312 9133330 71.43 µM 1.01351903470165 0.138663705121131 no 459 0.155406154443147 189 17617324
SGTC_2566 crystal violet carbinol 226 nM 1.01258601239484 0.138892305630302 no 460 0.155628971902708 216 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_786 4544-0069 423 µM 1.01141761619742 0.13917893698335 no 461 0.155908296614907 183 748821 YLR208W SEC13
SGTC_2434 5670830 169.91 µM 1.01105990395989 0.139266771504883 no 462 0.155993879764171 187 1549830
SGTC_119 0121-0043 24.815 µM 1.00948330706191 0.139654346711742 no 463 0.156371451678307 197 1092378
SGTC_2547 epiafzelechin trimethyl ether 100 µM 1.00814748848442 0.139983304756891 no 464 0.156691831349288 150 6708630 An antioxidant.
SGTC_2715 st079500 56.4 µM 1.00608078836773 0.140493286114737 no 465 0.157188354690137 196 28246688
SGTC_2899 9053889 58.44 µM 1.00529289553995 0.140688039158639 no 466 0.157377917520898 179 6470052
SGTC_1809 st050081 57.6 µM 1.00522908463005 0.140703820092695 no 467 0.157393276662101 200 5036894
SGTC_2280 7785178 200 µM 1.00458214192552 0.140863881879185 no 468 0.157549049932653 174 2954328
SGTC_2200 6600604 21.907 µM 0.998244050671729 0.142438538509972 no 469 0.159080515303636 207 2904777
SGTC_688 0527-0193 473 µM 0.998168534531424 0.142457371488781 no 470 0.159098820774652 213 4007154
SGTC_1546 5-methoxyflavanone 78.7 µM 0.996154962097236 0.142960157769391 no 471 0.159587429220066 161 147795
SGTC_1048 3161-0300 24.5 µM 0.99481280192332 0.143295958581004 no 472 0.159913659349714 174 2165101
SGTC_890 0929-0006 47.2 µM 0.98964800809665 0.144593126422759 no 473 0.161173097923948 170 1378169
SGTC_2973 9094665 17.96 µM 0.988970516825138 0.144763867328107 no 474 0.161338783476011 205 25237061 YIL048W NEO1
SGTC_1600 coumarin 106 71.1 µM 0.988898521720868 0.144782019464905 no 475 0.161356396944167 191 100336 A hepatotoxic, DNA x-linker.
SGTC_446 go6976 132 µM 0.988197171852774 0.144958931112542 no 476 0.161528046495272 181 3501 A protein kinase C inhibitor.
SGTC_2543 pimpinellin 60.67 µM 0.988071744250616 0.144990584869174 no 477 0.161558756403008 183 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_1270 0831-1170 17.3 µM 0.987403414606302 0.145159327497063 no 478 0.161722455543648 190 6764716
SGTC_3224 9130643 49.47 µM 0.986272454309828 0.145445177958717 no 479 0.161999716538334 194 17644395
SGTC_426 0988-0037 14.6 µM 0.986133964432219 0.145480207306774 no 480 0.162033689342219 207 5383008
SGTC_1792 st045773 43.6 µM 0.985614688758521 0.145611602359649 no 481 0.162161113618661 113 2919270
SGTC_63 0099-0242 26.702 µM 0.984728676810443 0.145835978791653 no 482 0.162378681365006 211 3898502 YLR359W ADE13
SGTC_2524 avocatin b 10.57 µM 0.984193174480896 0.145971703680435 no 483 0.162510270578273 149 6710748
SGTC_133 0724-0033 378.92 µM 0.982919033418383 0.146294980192173 no 484 0.162823644687478 188 280309
SGTC_190 3970-0790 3.722 µM 0.982496661665964 0.146402250850838 no 485 0.162927613395128 173 2832352
SGTC_2320 7373003 200 µM 0.978223456671355 0.147490495310899 no 486 0.163981908761179 187 5415828
SGTC_544 k015-0020 52.4 µM 0.977530899096052 0.147667375942835 no 487 0.164153194124034 199 3008304
SGTC_1054 3429-0080 167 µM 0.97551225075737 0.148183753180944 no 488 0.164653113927716 185 1162877
SGTC_3316 9136639 10.545 µM 0.975227635163495 0.148256655901076 no 489 0.164723678462649 197 4903665
SGTC_2750 bromebric acid 70.15 µM 0.974896880493046 0.148341407031915 no 490 0.164805706834609 183 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_2728 chlorpromazine 9.18 µM 0.97456701596487 0.148425962346514 no 491 0.164887540795774 224 2726 A thorazine and dopamine antagonist.
SGTC_619 1652-1634 108 µM 0.973678591604452 0.148653855522141 no 492 0.165108075122357 181 5400454
SGTC_2372 9071633 200 µM 0.972541959035716 0.148945758442424 no 493 0.165390500663015 179 21321366
SGTC_895 0964-0006 13.7 µM 0.971403318638799 0.149238560730005 no 494 0.165673738300535 225 6738897
SGTC_1633 st005664 67.9 µM 0.970864859830406 0.149377159610606 no 495 0.165807789492543 179 2063822
SGTC_1091 telmisartan 47.6 µM 0.969200645494976 0.149806070144577 no 496 0.166222544544531 194 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_3297 9117502 71.43 µM 0.965106066324147 0.150864841549761 no 497 0.167245844402355 153 7453720
SGTC_577 r071-0003 38.6 µM 0.964738045404494 0.150960247340621 no 498 0.167338017099739 207 4568517 YMR134W ERG29
SGTC_716 1683-5115 658 µM 0.963585241118963 0.151259360320012 no 499 0.167626954595739 197 723597
SGTC_2476 5806916 10.51 µM 0.962919191218366 0.151432356873036 no 500 0.167794038923737 186 2870194
SGTC_79 0052-0007 94.094 µM 0.962910369658242 0.15143464902449 no 501 0.167796252607013 188 2801472
SGTC_1292 0kpi-0043 232 µM 0.962698656951459 0.151489666349533 no 502 0.16784938545803 202 3333905
SGTC_3186 9110464 49.47 µM 0.961967579724103 0.151679751982584 no 503 0.168032944808347 176 17018021
SGTC_2265 7929201 200 µM 0.958581252450626 0.152562289759877 no 504 0.168884870379668 229 1265108
SGTC_1251 0490-5699 265 µM 0.95738050077649 0.15287604384751 no 505 0.169187618391887 209 3883818
SGTC_2312 7706453 155.7 µM 0.95616660575468 0.153193666883756 no 506 0.169494034233951 192 976098
SGTC_623 k072-0108 16.9 µM 0.953309446160466 0.153942984971571 no 507 0.170216653405016 209 5382803
SGTC_2925 9010536 32.5 µM 0.950901588844255 0.15457634925099 no 508 0.170827167595055 172 2994177
SGTC_1078 idebenone 36.1 µM 0.950765786220702 0.15461212209065 no 509 0.170861642154693 220 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_3314 9135860 59.4275 µM 0.949213294164282 0.155021465026634 no 510 0.171256070737184 191 25252478
SGTC_1312 1218-2183 165 µM 0.947945318581372 0.155356320452395 no 511 0.171578646163286 201 6744073
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM 0.946581932256132 0.155716904741892 no 512 0.171925927110949 207 688803
SGTC_39 0986-0283 58.349 µM 0.946318919543784 0.15578652900214 no 513 0.171992973156413 188 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1182 1222-0449 220 µM 0.944885917949566 0.156166231182246 no 514 0.172358560796169 200 658318
SGTC_1412 3909-8563 178 µM 0.944872475828001 0.156169795823144 no 515 0.17236199249799 211 23767530
SGTC_2054 5233173 129 µM 0.944366775600364 0.15630393857858 no 516 0.172491126727889 142 6889
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.944296474826273 0.156322592668141 no 517 0.172509083425434 173 77254
SGTC_3008 9078912 71.4286 µM 0.944087577799613 0.156378031490167 no 518 0.172562448345925 201 16648731
SGTC_691 1548-0686 185 µM 0.943036378682828 0.156657203919149 no 519 0.172831147848902 232 46495133
SGTC_2858 9025781 8.96 µM 0.941062532327209 0.157182294397304 no 520 0.173336407391581 200 4894980 YPL153C RAD53
SGTC_1117 retinoic acid 1.10837 µM 0.941020634917427 0.157193452642606 no 521 0.173347142353046 190 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_639 0833-0042 114 µM 0.940605361584087 0.15730407766256 no 522 0.173453566644619 222 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_760 0568-0725 82.9 µM 0.939685690501024 0.157549251773048 no 523 0.173689403610874 214 3916171
SGTC_982 1491-0518 27.5 µM 0.93947544755489 0.157605335454283 no 524 0.173743346150127 188 3091256
SGTC_1486 3970-0793 4.53 µM 0.938808696701932 0.157783282357451 no 525 0.173914486502015 213 2844330
SGTC_2366 9070441 60.58 µM 0.937415054110481 0.15815565297437 no 526 0.1742725501218 184 6837235
SGTC_2518 prenyletin 46.28 µM 0.936577040830386 0.1583798411584 no 527 0.174488083247755 167 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_2843 9000894 45.46 µM 0.93553746123101 0.158658242644269 no 528 0.174755693476534 128 2242070
SGTC_1738 st035555 74 µM 0.935099257282295 0.158775690609104 no 529 0.174868574648235 203 5331140
SGTC_351 caspofungin 25 nM 0.934777655306338 0.158861923021971 no 530 0.174951448632248 210 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_2175 5807670 165.306 µM 0.932322919679467 0.159521132131069 no 531 0.175584833163285 166 241186
SGTC_1217 1183-1422 255 µM 0.930447016324695 0.160026103486816 no 532 0.176069842469898 200 2849664
SGTC_1667 st014849 34.6 µM 0.93044486011354 0.160026684514548 no 533 0.176070400439515 201 5348460
SGTC_1965 Pectolinarigenin 58.4 µM 0.930098625716812 0.160120001151228 no 534 0.176160011136708 193 5320438 An anti-inflammatory.
SGTC_2252 omeprazole 400 µM 0.927702079755973 0.160766890219702 no 535 0.176781064679226 178 4594 A proton pump inhibitor.
SGTC_2582 agaric acid 100 µM 0.927522625754529 0.160815398025638 no 536 0.176827624969781 222 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_439 amiodarone 34.4 µM 0.926849651886831 0.160997393175148 no 537 0.177002300631978 198 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_389 tpck 16.7 µM 0.924779936631806 0.16155795706935 no 538 0.177540194486086 185 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_917 harmaline 728.087 nM 0.923675278865195 0.161857663937969 no 539 0.177827703432129 194 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_463 ikarugamyin 104 µM 0.9204253506823 0.162741507564953 no 540 0.178675263053841 192 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_70 0141-0289 43.283 µM 0.920071745436083 0.162837862304158 no 541 0.178767634133424 206 352408
SGTC_3176 9106582 49.47 µM 0.918751748650714 0.163197879039005 no 542 0.179112717853858 148 17018027
SGTC_1553 gossypol 38.6 µM 0.91843569969778 0.163284155112973 no 543 0.179195403941994 191 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_523 1934-0222 13.7 µM 0.917663030830484 0.16349520553978 no 544 0.179397653976728 216 1361595
SGTC_759 3486-0358 89.3 µM 0.915846852498705 0.163991982359869 no 545 0.179873612820577 229 875103
SGTC_2910 7948405 25.97 µM 0.914874852175802 0.164258254194211 no 546 0.180128666709537 184 2971328
SGTC_660 4031-1742 102 µM 0.914027202609388 0.164490689835733 no 547 0.180351276055712 203 6738706
SGTC_2123 5259487 200 µM 0.911492793734707 0.165186925962912 no 548 0.181017890422718 189 2173474
SGTC_3059 1327-0034 3 µM 0.909391385659952 0.165765655245546 no 549 0.181571783655063 196 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1252 0493-0875 34.8 µM 0.909229534703133 0.165810283417469 no 550 0.18161448859497 177 3960963
SGTC_2092 5303694 80.6725 µM 0.908578880228261 0.165989770791726 no 551 0.181786229465703 207 1963699
SGTC_2450 5739737 12.93 µM 0.906962176343599 0.166436292678297 no 552 0.182213399652632 210 2262825
SGTC_1449 4112-4002 201 µM 0.905130200829064 0.166943207412154 no 553 0.182698207088933 184 2059539
SGTC_1596 piperlongumine 63 µM 0.90425522138069 0.167185668627144 no 554 0.182930042435993 183 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2153 5569715 200 µM 0.904199828451351 0.167201025923936 no 555 0.182944725573319 214 2054701
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 0.902883560086797 0.167566219521881 no 556 0.183293848355741 201 6710655
SGTC_1416 3966-0321 25.3 µM 0.90277196604094 0.167597204470624 no 557 0.183323466293342 207 582530 YLR208W SEC13
SGTC_1880 MG-132 525 µM 0.900620300128214 0.168195352618721 no 558 0.183895118706138 213 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_918 glabranin 770.725 nM 0.898980236589132 0.168652200101663 no 559 0.184331593857827 187 124049 Also referred to as licorice root.
SGTC_35 0133-0054 64.071 µM 0.898397744963084 0.168814647668788 no 560 0.184486769138718 218 99677
SGTC_257 daunorubicin 18.5 µM 0.897619791362892 0.169031763195046 no 561 0.18469414200735 201 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2033 5192550 145 µM 0.897047257318448 0.169191663622825 no 562 0.18484685036407 202 182073
SGTC_113 0099-0221 2.5 µM 0.894366070840455 0.169941771807776 no 563 0.185563029900506 205 89219
SGTC_2952 9073731 13.78 µM 0.893437790019809 0.170201970469823 no 564 0.18581138645278 217 16457353
SGTC_1871 st057448 67.3 µM 0.89127591653872 0.170808936119415 no 565 0.186390582795932 223 691747
SGTC_3245 9134821 49.47 µM 0.890878994603953 0.170920525889026 no 566 0.18649704516419 230 17014901
SGTC_200 k038-0079 37.545 µM 0.890809582788164 0.170940044966455 no 567 0.186515666663735 225 3436683
SGTC_2449 5812982 45.77 µM 0.889020011928959 0.171443776840846 no 568 0.186996162418044 198 776185
SGTC_2688 kanamycin b 96.69 µM 0.888978503825597 0.171455471868806 no 569 0.187007316330133 217 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_220 paclitaxel 373.376 µM 0.88799677795664 0.171732224593685 no 570 0.187271242242257 191 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1288 0973-0013 65.5 µM 0.886624338759455 0.172119599070723 no 571 0.187640592834794 200 4315430
SGTC_505 gw-5074 63.9 µM 0.885256418151434 0.172506252654495 no 572 0.188009174880403 221 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1379 2144-0755 36.5 µM 0.884955445061437 0.172591399369283 no 573 0.188090331110989 234 5392327
SGTC_2947 9072639 7.68 µM 0.883605629656285 0.17297359806922 no 574 0.188454569490124 217 16488146
SGTC_1742 st038235 28.8875 µM 0.880709758987319 0.173795378401751 no 575 0.189237466679955 228 564103 YBR002C RER2
SGTC_1733 st037357 54.9 µM 0.879895501301587 0.174026892240146 no 576 0.189457961010645 223 1272339 YGL099W LSG1
SGTC_2793 7325131 81.82 µM 0.877400821204333 0.174737412079798 no 577 0.190134483637826 211 4176441
SGTC_3017 9080681 49.47 µM 0.877187782808797 0.174798173629284 no 578 0.190192325410796 216 16451914
SGTC_2595 hexamethylquercetagetin 100 µM 0.874557678507103 0.175549420959397 no 579 0.190907311911479 232 386331
SGTC_334 1502-1024 68.5 µM 0.874374326619599 0.175601868686785 no 580 0.190957217014409 201 3296216
SGTC_1692 fluoroquinolonic acid 71 µM 0.873932512250216 0.175728290280495 no 581 0.191077503849092 207 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1618 st003135 44.5 µM 0.873369812468906 0.175889385714127 no 582 0.191230769780243 229 1270615
SGTC_258 haloperidol 50.781 µM 0.872978536024134 0.176001459437518 no 583 0.191337388513033 242 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2799 7812892 81.82 µM 0.870759877634227 0.176637806895201 no 584 0.191942638409046 239 20205235
SGTC_1320 1313-0481 95.3 µM 0.87042305056974 0.176734541442654 no 585 0.192034627165199 204 6813365 YLR208W SEC13
SGTC_1080 nisoldipine 24.4 µM 0.869630203288667 0.176962374209554 no 586 0.192251263249302 219 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_1205 4161-2785 76 µM 0.869131585319838 0.177105752195884 no 587 0.192387581210039 199 3498106
SGTC_349 k015-0014 24 µM 0.867701657881972 0.177517335797775 no 588 0.192778839022939 212 2196908
SGTC_875 0709-0210 25.7 µM 0.865623332736449 0.178116626614991 no 589 0.193348377937383 229 6251364
SGTC_404 fumagillin 50 µM 0.863338010856529 0.178777075929451 no 590 0.193975825533747 234 12015870 A methionine aminopeptidase binder.
SGTC_465 cgp-37157 41 µM 0.862501847499753 0.179019108685901 no 591 0.194205708434959 194 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_794 k038-0031 316 µM 0.860621571387548 0.179564119115182 no 592 0.194723250627076 209 6624242
SGTC_1519 esterone 74 µM 0.860350796024666 0.179642690952035 no 593 0.194797850051203 216 698 A steroid.
SGTC_998 3996-0085 177 µM 0.859558038981078 0.179872852237878 no 594 0.195016356921766 211 715391
SGTC_1558 st069300 45.6 µM 0.859282538862397 0.179952881581664 no 595 0.195092327634621 219 24208000
SGTC_2528 xanthyletin 44.79 µM 0.859280487072157 0.179953477684977 no 596 0.195092893494841 225 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_53 0973-0023 39.979 µM 0.856012051992362 0.180904624815663 no 597 0.195995556571044 226 674768
SGTC_1638 st008370 60.6 µM 0.855851161696645 0.180951526715588 no 598 0.196040055928434 223 24207134
SGTC_2220 6782180 200 µM 0.855075289287747 0.181177811957573 no 599 0.196254734282449 200 833803
SGTC_3274 9138298 49.47 µM 0.854439352724577 0.181363416656892 no 600 0.196430799633388 241 17015756
SGTC_2099 5377090 177.372 µM 0.853597027096952 0.181609441354262 no 601 0.196664153162291 226 2243829
SGTC_556 4058-0063 51.5 µM 0.853175886772749 0.181732525411276 no 602 0.196780886635816 215 6615692
SGTC_1708 st033234 31.827 µM 0.852961095170523 0.181795321305938 no 603 0.196840439643847 210 674664
SGTC_653 0203-0016 55.2 µM 0.851179318659847 0.182316759883055 no 604 0.197334874693567 222 295302
SGTC_993 3909-8757 62.7 µM 0.84728605596115 0.183459374924135 no 605 0.198417848474677 210 4288324 YLR208W SEC13
SGTC_1326 1431-2094 10.8 µM 0.846801676342847 0.183601844758672 no 606 0.198552836860401 226 616278
SGTC_2350 9023895 38.85 µM 0.845971662725557 0.183846135634873 no 607 0.198784276329903 221 2997209
SGTC_2744 captopril 92.04 µM 0.843824562604412 0.184479012068336 no 608 0.199383723850055 162 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_166 k072-0058 166.424 µM 0.843616164703126 0.184540511226654 no 609 0.199441964215546 244 5846229
SGTC_1464 k208-0027 110 µM 0.843611223769265 0.184541969473186 no 610 0.199443345168474 231 X1464
SGTC_254 nsc-64875 3.808 µM 0.841129583043606 0.185275296077083 no 611 0.200137671902027 198 56993
SGTC_459 nigericin 15.3 µM 0.841091884167851 0.185286450056458 no 612 0.200148230685887 230 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_2270 7924575 90.91 µM 0.840661309194865 0.185413873997435 no 613 0.200268850817733 230 1262135
SGTC_489 paxilline 115 µM 0.840205161347914 0.185548925275207 no 614 0.200396682502458 237 105008 A toxic potassium channel blocker.
SGTC_46 0329-0187a 2.197 µM 0.838847081143433 0.185951372157138 no 615 0.200777563413603 221 46494817
SGTC_2091 4-phenylthiadiazole 200 µM 0.836693994744623 0.186590515548735 no 616 0.201382297780202 208 270010
SGTC_2486 5283202 22.39 µM 0.834090104879693 0.18736529476972 no 617 0.20211510535556 221 1377751
SGTC_903 1134-0042 114 µM 0.83401727715018 0.18738699298153 no 618 0.202135624031022 231 701009
SGTC_1983 st071813 46.9 µM 0.832895070780232 0.187721538231016 no 619 0.202451954942351 215 11838595
SGTC_2271 7849410 118.62 µM 0.832230473219172 0.187919837794782 no 620 0.20263943317809 246 972430
SGTC_1564 D-Arginine 115 µM 0.830371060083745 0.188475327721593 no 621 0.203164511343658 246 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_2017 5132927 60.65 µM 0.830266247556844 0.188506670034631 no 622 0.20319413342959 204 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_467 ro 31-8220 72.8 µM 0.830253655178269 0.188510435776658 no 623 0.203197692457431 233 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_1743 st037606 46.3785 µM 0.829586257009477 0.188710087112203 no 624 0.203386374770353 191 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_1745 st081495 74 µM 0.829004745423308 0.188884151796673 no 625 0.20355086099807 228 13842402 YBL026W LSM2
SGTC_3196 9111891 49.47 µM 0.828708245247637 0.188972941680567 no 626 0.203634759497797 245 18891510
SGTC_18 0111-0177 500 nM 0.826884768490697 0.189519564802504 no 627 0.20415118867501 233 721752
SGTC_655 k060-0012 42 µM 0.826268135041485 0.189704632750264 no 628 0.204326002562558 239 5994525
SGTC_880 0833-0487 87.2 µM 0.82616213052094 0.189736458693373 no 629 0.20435606352748 241 76075
SGTC_2240 6690706 185.951 µM 0.822690574648013 0.190780544662635 no 630 0.205341988295334 207 805876
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM 0.822607650420781 0.190805527531062 no 631 0.205365573343323 250 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_2511 berberine 10.47 µM 0.822467687533862 0.190847699186718 no 632 0.205405384797016 247 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_874 0599-0792 117 µM 0.821768807367894 0.191058361522033 no 633 0.205604244893544 227 765305
SGTC_3054 9094397 49.47 µM 0.821637449379515 0.191097972465766 no 634 0.205641634388549 230 2598354
SGTC_2371 9071574 200 µM 0.820229792845198 0.191522766740766 no 635 0.206042560441222 231 45596039
SGTC_2193 5925765 200 µM 0.819523933447572 0.191735994422675 no 636 0.206243776346823 216 877370
SGTC_2755 lomerizine 42.69 µM 0.818806094948898 0.191952989804753 no 637 0.206448526487752 215 3949 A calcium channel blocker.
SGTC_1847 st056231 15 µM 0.816599844141259 0.192620857675613 no 638 0.207078572097467 239 5393180
SGTC_2461 5755302 26.15 µM 0.815340421066511 0.193002741399583 no 639 0.207438738744931 250 2788904
SGTC_1955 wogonin 32.4 µM 0.815047819983364 0.193091530379558 no 640 0.207522469045748 211 5281703 A flavanone.
SGTC_1267 0828-0272 9.49 µM 0.814554996449511 0.193241132665114 no 641 0.207663539855683 226 745334
SGTC_2988 9073640 71.4286 µM 0.814467463944876 0.193267711566068 no 642 0.207688601972116 235 9102229
SGTC_737 1950-0117 57.9 µM 0.814421733238023 0.193281598402697 no 643 0.20770169619929 232 5393513
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.813902208929522 0.193439402747829 no 644 0.207850487581725 230 5106787 A p450 inhibitor.
SGTC_968 1309-0633 340 µM 0.812924473437317 0.193736600795607 no 645 0.20813068095877 238 3761976
SGTC_2738 aclarubicin 5.55 µM 0.812596805515812 0.193836262850294 no 646 0.208224631848666 198 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2317 5986382 200 µM 0.810071419833185 0.194605421305183 no 647 0.208949564626575 254 877883
SGTC_1427 4048-4900 550 nM 0.808523297433396 0.195077850917325 no 648 0.209394699999911 246 24132586
SGTC_2809 7964133 12.99 µM 0.807762220907271 0.195310358674329 no 649 0.209613738609021 246 1253665
SGTC_807 1315-0151 48 µM 0.807416625477244 0.195415993130545 no 650 0.209713245802754 264 4011080
SGTC_2357 9067248 200 µM 0.806298804048075 0.195757903228203 no 651 0.210035289963137 234 9150235
SGTC_3229 9132204 49.47 µM 0.806149164337446 0.195803701342949 no 652 0.210078423179683 227 17682924
SGTC_1629 st005085 44.9 µM 0.80124488656185 0.197308281048163 no 653 0.211494945074692 260 24207091
SGTC_701 4424-0219 185 µM 0.800785736918887 0.197449500336675 no 654 0.211627848783924 229 2911779
SGTC_2618 avocadyne 43.43 µM 0.7998334202011 0.197742596330192 no 655 0.211903658559359 242 3015189
SGTC_3354 9151612 71.43 µM 0.799553660751171 0.197828748266573 no 656 0.211984722376694 215 27261949
SGTC_283 0987-0079 11.7 µM 0.798903081520043 0.198029181840259 no 657 0.212173306004379 227 411556
SGTC_712 r015-0009 80.6 µM 0.796413524533296 0.198797308355727 no 658 0.212895859923199 235 6813872 YLR060W FRS1
SGTC_1489 4065-0444 182 µM 0.796330318231919 0.198823011762593 no 659 0.212920033989807 233 2877968
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.795976033442332 0.198932476932198 no 660 0.213022982875047 225 17037758
SGTC_373 0844-0104 25.9 µM 0.795635436282776 0.19903774720238 no 661 0.213121981752367 237 5375804
SGTC_905 2-aminofluorene 215 µM 0.795477319439125 0.199086628665985 no 662 0.213167949534732 246 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2427 5545055 42.75 µM 0.795354412305794 0.199124630123074 no 663 0.213203685132322 242 5372858
SGTC_920 mycophenolic acid 780.421 nM 0.795118854633534 0.199197474029305 no 664 0.21327218395724 230 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2258 7960471 200 µM 0.793677270422293 0.19964361942858 no 665 0.213691667891794 241 2974708
SGTC_3154 9100113 49.47 µM 0.792282017236473 0.200075998257347 no 666 0.214098127375087 234 25237525
SGTC_1160 4092-0570 10.5 µM 0.792221106174306 0.200094886968067 no 667 0.214115881981548 242 4994975
SGTC_201 4262-0159 12.803 µM 0.791456180280906 0.200332184121115 no 668 0.214338918651461 230 1341029
SGTC_2314 7727897 200 µM 0.790883915722436 0.200509823920039 no 669 0.214505867561637 223 900724
SGTC_3047 9092122 49.47 µM 0.79005866075224 0.200766162375717 no 670 0.214746755399177 236 17173831
SGTC_3338 9144300 39.5675 µM 0.788609515185225 0.201216767702039 no 671 0.215170133942443 212 4901274
SGTC_3227 9130768 49.47 µM 0.788147625143834 0.201360517686371 no 672 0.215305180276608 246 17720899
SGTC_1494 4358-1428 177 µM 0.787565429348152 0.201541797041255 no 673 0.215475471375236 222 1564571
SGTC_3095 9117207 49.47 µM 0.784642694005274 0.202453331031351 no 674 0.216331545315271 204 17015229
SGTC_132 0417-1715 25.805 µM 0.783174325271552 0.202912210285103 no 675 0.216762374856147 241 6769098
SGTC_809 3998-0021 90 µM 0.783040683989069 0.202954005283303 no 676 0.216801610750441 258 715485
SGTC_236 1509-0011 5.31 µM 0.7818217158208 0.20333546286994 no 677 0.217159678483734 280 3107280
SGTC_2603 homopterocarpin 100 µM 0.781393832656523 0.203469463790223 no 678 0.217285448665226 249 101795 A weak amylase inhibitor.
SGTC_125 0133-0007 11.75 µM 0.7804787760896 0.203756210391078 no 679 0.217554557686913 246 26541
SGTC_5 0352-0601 109.883 µM 0.779660849600167 0.204012723628936 no 680 0.217795264455729 230 762456
SGTC_1554 st069299 38.7 µM 0.779406325028486 0.204092585344752 no 681 0.217870199565729 223 24207999
SGTC_1508 1080-0625 72.9 µM 0.779312631980503 0.204121987932079 no 682 0.21789778767511 238 767111
SGTC_189 3970-0742 2.116 µM 0.778308524570265 0.204437253534609 no 683 0.218193575612162 240 2891807
SGTC_1448 4255-0083 152 µM 0.776612405853202 0.204970451855326 no 684 0.218693740012006 257 5399660
SGTC_1502 4534-4282 27.7 µM 0.776476897616997 0.205013086372689 no 685 0.218733728159226 258 3278949
SGTC_390 dec-rvkr-cmk 16.7 µM 0.776471967712334 0.205014637551995 no 686 0.218735183041293 227 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1691 st019933 84.6 µM 0.775305455236874 0.205381873203948 no 687 0.219079593308549 262 6176082
SGTC_1646 st011709 75.6 µM 0.774875117969841 0.205517448430824 no 688 0.219206728145397 244 5757843
SGTC_617 3770-0098 35 µM 0.774809593781386 0.205538096101653 no 689 0.219226089721568 253 5962639
SGTC_2224 6650123 117.647 µM 0.773494756001571 0.205952681792832 no 690 0.219614815524632 250 2908370
SGTC_3225 9130819 49.47 µM 0.771028518330387 0.206731655483544 no 691 0.22034501401712 263 4547121
SGTC_3128 9127691 49.47 µM 0.769657618684729 0.207165414413414 no 692 0.220751508229958 245 41316314
SGTC_930 2810-3379 265 µM 0.766733612827467 0.208092379879505 no 693 0.221619957256671 258 1015764
SGTC_1779 st039427 55 µM 0.766192935443269 0.208264052689627 no 694 0.221780755632333 252 1124498
SGTC_587 k089-0003 57 µM 0.764393171907429 0.208836105057438 no 695 0.222316488281706 249 9659696
SGTC_335 4077-0256 27.6 µM 0.763903207710053 0.208991999684769 no 696 0.222462462870397 258 3121989
SGTC_2938 9059746 27.26 µM 0.763130565455145 0.209237974777378 no 697 0.222692766502743 241 6471769
SGTC_2630 antimycin a 100 µM 0.762593429284111 0.209409075529555 no 698 0.222852952222083 265 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_1499 4480-0877 67.3 µM 0.762472715546842 0.209447539324227 no 699 0.222888960723398 236 2861909
SGTC_1930 st074634 34.3 µM 0.760903848616995 0.209947815444931 no 700 0.223357249823879 250 684253 YOR116C RPO31
SGTC_65 0798-0905 34.986 µM 0.760388510913545 0.210112298057525 no 701 0.223511194389999 258 3602145
SGTC_1194 1488-0194 225 µM 0.757603946747857 0.211002368425326 no 702 0.224344058369394 245 1391452
SGTC_2586 curcumin 80 µM 0.755484958602092 0.211681169717808 no 703 0.224979026999552 237 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_2564 betulinic acid 100 µM 0.755368369937341 0.211718555044434 no 704 0.225013993091778 264 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2745 rifampicin 24.3 µM 0.755340253198877 0.211727571537365 no 705 0.22502242604027 211 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_2267 7931562 200 µM 0.755299252818757 0.211740719967162 no 706 0.225034723452347 230 934880
SGTC_864 0469-0573 172 µM 0.752248248273437 0.212720488023682 no 707 0.22595089171467 255 689425
SGTC_2623 humulene 100 µM 0.752001073595536 0.212799978883975 no 708 0.226025206579563 242 6187145 An anti-inflammatory.
SGTC_1263 0774-1208 64.8 µM 0.751311949145747 0.213021691410964 no 709 0.226232469799865 278 906585
SGTC_1475 4092-1048 11.7 µM 0.751183868846673 0.213062913629105 no 710 0.226271003460435 258 2881759
SGTC_801 0866-0028 10.1 µM 0.750784592922579 0.213191449119076 no 711 0.226391151605474 255 6849771
SGTC_1701 st028638 40.4 µM 0.750683691464238 0.213223938621057 no 712 0.226421520077659 248 3490878
SGTC_1434 4073-0095 163 µM 0.750218474604743 0.213373772251944 no 713 0.226561566885748 247 24133745
SGTC_912 3474-0017 2.18 µM 0.748023509544558 0.214081537969145 no 714 0.227222988616564 256 3360550
SGTC_3305 9127027 53.8275 µM 0.746104450969043 0.214701455712698 no 715 0.227802160399865 252 41905295
SGTC_1523 st012844 44.7 µM 0.745874722651212 0.214775735208727 no 716 0.227871548030445 235 4274103
SGTC_3110 9122132 49.47 µM 0.74586424360418 0.214779123820681 no 717 0.227874713427712 234 918317
SGTC_183 3914-0051 30.55 µM 0.743682685543732 0.21548525087991 no 718 0.228534233382304 242 1596232
SGTC_942 3253-1115 227 µM 0.742170412204429 0.215975533018118 no 719 0.22899204638787 280 46497897
SGTC_2850 9015429 58.44 µM 0.742114944220375 0.215993528131431 no 720 0.229008848079603 279 6457570
SGTC_2803 7707263 71.43 µM 0.74150733530998 0.216190707559367 no 721 0.229192942910813 240 2199229
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.740082407579751 0.216653529471248 no 722 0.229624996350525 250 521171
SGTC_3236 9132701 49.47 µM 0.739603615920059 0.216809171353298 no 723 0.229770273482863 256 24282524
SGTC_632 0781-2353 4.65 µM 0.739294275195223 0.216909763806801 no 724 0.229864162407636 263 6811515 YHR007C ERG11
SGTC_248 streptozotocin 5.23457 mM 0.739187226223925 0.216944580632483 no 725 0.229896658161429 272 5300 DNA alkylating agent.
SGTC_2118 5526350 200 µM 0.737694752405813 0.217430332211714 no 726 0.230349980837017 257 743594
SGTC_1790 st045711 43.5 µM 0.737448249277444 0.217510621321158 no 727 0.230424901542256 215 585119
SGTC_410 α-linolenic acid 100 µM 0.736702246385057 0.217753707902385 no 728 0.230651720231632 255 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1726 st035556 14.5795 µM 0.735900551020212 0.218015116613674 no 729 0.230895610955272 224 5919439
SGTC_2294 7971431 200 µM 0.73553082223269 0.218135734967436 no 730 0.231008137867019 277 5741572
SGTC_1659 st012954 42.1 µM 0.733856611781446 0.218682401652835 no 731 0.231518066583772 261 24207262
SGTC_1457 k015-0032 57.3 µM 0.733825554893278 0.218692549856596 no 732 0.231527531772499 262 4302660
SGTC_1447 4239-0816 81.9 µM 0.733736876810906 0.218721527955698 no 733 0.231554559324513 251 1341554
SGTC_891 0929-0073 133 µM 0.732373502888291 0.219167327456159 no 734 0.231970313519129 267 5603632
SGTC_2923 7992654 58.14 µM 0.732012208553055 0.219285551902565 no 735 0.23208055808616 249 2985126
SGTC_1514 1189-1591 158 µM 0.731575700003895 0.219428437182254 no 736 0.23221379225235 270 767698 YMR146C TIF34
SGTC_3147 9097027 49.47 µM 0.729529714263736 0.220098875998144 no 737 0.232838849182221 285 25236841
SGTC_669 0108-0021 26.2 µM 0.72752211675714 0.220757876233326 no 738 0.23345308590695 300 17201
SGTC_2711 st079103 59.1 µM 0.727002594681159 0.220928594859133 no 739 0.233612183132817 253 54693780
SGTC_824 1304-0008 100 µM 0.726965613284778 0.220940750088002 no 740 0.233623510520802 261 768245
SGTC_1279 0874-0590 65.2 µM 0.726734783444387 0.221016629036899 no 741 0.233694220497616 255 3523074
SGTC_1132 3456-3614 2.5 µM 0.724994776590236 0.221589088076961 no 742 0.234227617450468 244 3125502
SGTC_1865 st057639 52.2 µM 0.72071433067312 0.223000947528509 no 743 0.235542646741367 273 688818
SGTC_1277 0873-0036 22 µM 0.718753137956967 0.223649533637969 no 744 0.23614651808088 261 5965735
SGTC_264 promethazine 12.5 mM 0.718650559530357 0.223683486846352 no 745 0.236178126481781 285 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_3173 9105693 49.47 µM 0.718609488793931 0.223697081981274 no 746 0.236190782625537 284 17096658
SGTC_377 3970-0964 33.1 µM 0.717457813847611 0.224078497852737 no 747 0.236545828822961 249 16481235
SGTC_1405 3909-7894 12 µM 0.716953970902118 0.224245478467223 no 748 0.236701249256471 268 7104060
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.71570107374005 0.224661012284778 no 749 0.237087973833923 253 803109
SGTC_2074 5212007 75.395 µM 0.71536757122222 0.224771694738211 no 750 0.237190972619356 257 758611
SGTC_2459 5811157 9.22 µM 0.715064636438414 0.224872259199219 no 751 0.237284552178528 266 2870684 YBR192W RIM2
SGTC_2008 4012253 172 µM 0.712657281481634 0.225672328645059 no 752 0.238028928346718 256 603940
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.710566563361184 0.226368470584752 no 753 0.238676434629764 268 5377381
SGTC_1413 3910-0535 34.4 µM 0.710224682295075 0.226482421260985 no 754 0.238782408590508 257 2876951
SGTC_1030 k029-0042 36.7 µM 0.708769345361075 0.226967854587121 no 755 0.239233811874377 257 6080581
SGTC_298 1391-0729 10 µM 0.708670769548133 0.227000756139386 no 756 0.239264404082296 267 3237558
SGTC_2805 7950783 58.44 µM 0.706593281621571 0.227694782554904 no 757 0.239909632603435 264 1178958 YDL195W SEC31
SGTC_2408 sulbentine 18.36 µM 0.705943019612314 0.227912260786594 no 758 0.24011178654225 253 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_368 fentichlor 4.58 µM 0.704824838478132 0.228286506325682 no 759 0.240459624542128 278 7329 A pesticide.
SGTC_1586 deoxycorticosterone acetate 53.7 µM 0.703534871559183 0.228718675845665 no 760 0.240861241442679 282 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_330 1488-0319 80.1 µM 0.703102065720536 0.228863778919844 no 761 0.240996072456723 270 6846614
SGTC_702 1488-0190 94 µM 0.702963595989616 0.228910213377221 no 762 0.241039218280897 247 949357
SGTC_630 4356-0227 183 µM 0.701208612099894 0.229499187840399 no 763 0.24158641803076 288 779312
SGTC_374 0880-0231 82.3 µM 0.700349454528887 0.22978783136113 no 764 0.241854547019218 270 6833587
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.698127614551405 0.23053522492381 no 765 0.242548694917593 274 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_595 3909-8003 73.7 µM 0.697388648356451 0.230784102784359 no 766 0.242779801829533 284 699517
SGTC_424 splitomicin 100 mM 0.697298213346264 0.230814570870047 no 767 0.242808092978818 285 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_1841 st054148 70 µM 0.695954248332386 0.231267625237687 no 768 0.243228741182948 281 675442
SGTC_2253 7938677 135.83 µM 0.695125479008261 0.231547252786223 no 769 0.243488334297055 248 2301972
SGTC_626 0214-0009 33 µM 0.695106486159431 0.231553663199563 no 770 0.243494285128111 276 3437874
SGTC_127 0180-0333 59.125 µM 0.695000061259218 0.231589585265126 no 771 0.243527631584583 236 771601
SGTC_2207 7258803 200 µM 0.694126409950578 0.231884590021664 no 772 0.243801468777099 277 3666799
SGTC_1075 aripiprazole 15.2 µM 0.68965823047713 0.233396622522072 no 773 0.245204569501644 264 60795 An atypical antipschotic. YIL048W NEO1
SGTC_618 k072-0232 33.2 µM 0.68871793757546 0.233715513003286 no 774 0.245500392934027 277 5872756 YGL099W LSG1
SGTC_1831 st055328 12 µM 0.688452842040786 0.233805461000781 no 775 0.24558382867905 268 1103068
SGTC_1042 0350-0096 82 µM 0.687164985538697 0.234242708855611 no 776 0.245989383220407 281 3122515
SGTC_1354 1498-1681 81 µM 0.686596879562224 0.234435733699997 no 777 0.246168397706697 263 5754243
SGTC_3026 9090633 49.47 µM 0.686245579086866 0.234555138762589 no 778 0.246279130089493 274 25236842
SGTC_1634 st006576 41 µM 0.685948503876332 0.234656139207688 no 779 0.246372791122268 270 3915356
SGTC_1144 3486-0183 12.5 µM 0.683434488269742 0.23551182336335 no 780 0.247166166680714 295 6744069
SGTC_2596 sinensetin 100 µM 0.682992641601748 0.235662390404989 no 781 0.247305746133298 285 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_1053 3366-3204 134 µM 0.682884595547237 0.235699217079889 no 782 0.247339884314971 291 3632071 YPR165W RHO1
SGTC_1454 4239-0054 42.6 µM 0.682535108755032 0.235818358724738 no 783 0.2474503252511 270 1340767
SGTC_2194 5927483 104.545 µM 0.681494718862302 0.236173228857174 no 784 0.247779253648527 244 760979
SGTC_1216 1165-0504 9.65 µM 0.680681806732818 0.236450712403207 no 785 0.248036425324831 282 6304004
SGTC_3050 9093513 49.47 µM 0.680163732645214 0.236627648017158 no 786 0.248200396745156 290 25236664
SGTC_2844 9010103 25.97 µM 0.679697684335408 0.236786877706757 no 787 0.248347951285964 296 2480525
SGTC_451 chloral hydrate 100 µM 0.679242041173468 0.236942609329315 no 788 0.248492256670291 293 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2465 5809242 33.21 µM 0.67775425146657 0.237451504150698 no 789 0.248963761068023 314 2731748
SGTC_796 1234-0020 70.7 µM 0.676818141482869 0.237772005550166 no 790 0.249260673164814 269 46495034
SGTC_141 0443-0274 32.331 µM 0.675396642744763 0.238259145708914 no 791 0.249711898956793 247 1627241
SGTC_2708 st078559 56 µM 0.674226859922287 0.238660433868263 no 792 0.250083547776229 256 17250902
SGTC_2813 7971799 71.43 µM 0.67358684891309 0.238880142884048 no 793 0.250287008220988 275 2234054
SGTC_2498 4'-Methoxychalcone 54.63 µM 0.671776021192552 0.239502379726993 no 794 0.250863148147607 271 641818 YHR062C RPP1
SGTC_774 k060-0086 136 µM 0.671696040317459 0.239529883156906 no 795 0.250888611349932 283 5911235
SGTC_1202 1988-0068 29.6 µM 0.671678979470452 0.239535750180189 no 796 0.250894043122937 269 2850480
SGTC_1937 st074714 47.2 µM 0.66948122325635 0.240292188159333 no 797 0.251594277242804 264 17250970
SGTC_2616 abietic acid 100 µM 0.667802192391757 0.240870963745442 no 798 0.252129933462835 289 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1693 xanthone 101.9 µM 0.666308813468223 0.241386380171463 no 799 0.252606866672134 296 7020 An insecticide.
SGTC_490 phenamil 164 µM 0.666267626461604 0.241400603709171 no 800 0.252620027098237 277 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1052 3253-3998 198 µM 0.666030556495868 0.241482482399965 no 801 0.252695784751397 266 5450317
SGTC_2800 7887935 81.82 µM 0.6659343019711 0.24151573087578 no 802 0.252726547089448 291 2961002
SGTC_607 4491-0986 66.8 µM 0.663693737465198 0.242290374230135 no 803 0.25344317419855 265 698981 YDR232W HEM1
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 0.663258894428197 0.242440870906398 no 804 0.253582378991993 271 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1552 6-methylflavone 10.6 µM 0.663254237560686 0.242442482895505 no 805 0.253583869996182 289 689013
SGTC_2398 5228213 48.84 µM 0.663139202772857 0.242482304386615 no 806 0.253620702514581 284 80771 YMR134W ERG29
SGTC_49 0717-0965 32.132 µM 0.662191305089659 0.242810572129194 no 807 0.253924312942876 308 5889349 YGL099W LSG1
SGTC_3175 9106517 49.47 µM 0.661108434479837 0.243185876651439 no 808 0.254271388302212 298 41468073
SGTC_1278 0874-0585 172 µM 0.660536095684943 0.243384366151726 no 809 0.254454931406543 280 766306
SGTC_833 3852-0053 558 µM 0.660519319707243 0.243390185451614 no 810 0.254460312335376 295 3123681
SGTC_449 xestospongin c 11.1929 µM 0.659635291236994 0.243696946157688 no 811 0.254743950594872 296 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_429 1112-0049 25.5 µM 0.658837477406235 0.243973969206279 no 812 0.255000069144568 269 2836170
SGTC_2878 9043973 25.97 µM 0.656792634548649 0.244684770327054 no 813 0.255657130411892 297 6465167
SGTC_2324 6149169 200 µM 0.655642689020705 0.245084988444226 no 814 0.256027025891741 280 2888231
SGTC_2130 NSC 7 2.4545 µM 0.655135523890845 0.245261610082359 no 815 0.256190251063725 271 21448
SGTC_1941 st076221 61.8 µM 0.65498530381668 0.24531393776517 no 816 0.256238608053291 269 2828568
SGTC_25 0118-0223 35.662 µM 0.654692084092464 0.245416095254182 no 817 0.256333011430419 293 5333628
SGTC_1662 st014054 52 µM 0.653233987765995 0.245924434027169 no 818 0.256802721000562 286 2838777
SGTC_1420 4'-methoxyflavone 42 µM 0.650879642374778 0.246746425059162 no 819 0.257562091873193 278 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_961 1252-1571 372 µM 0.648005125499905 0.24775201875568 no 820 0.258490817598075 306 6813498
SGTC_3094 9117742 49.47 µM 0.647215322171152 0.248028698779608 no 821 0.258746298054241 306 17149698
SGTC_2946 9065502 71.43 µM 0.6448507018291 0.248858045647493 no 822 0.259511970729021 253 16489101
SGTC_2428 5615643 7.78 µM 0.644827518337054 0.248866184129809 no 823 0.259519483416112 310 2253075
SGTC_2352 9027995 87.8 µM 0.644473716139406 0.248990402708318 no 824 0.259634148119604 289 2997347
SGTC_1014 4130-3005 69.3 µM 0.642357553123922 0.249734067636713 no 825 0.260320526703776 295 743608
SGTC_416 estradiol valerate 100 µM 0.641682969855828 0.249971378301537 no 826 0.260539524478171 301 13791 A steroid.
SGTC_3113 9123498 49.47 µM 0.640894400643651 0.250248939552369 no 827 0.260795647028509 311 8897275
SGTC_3098 9119039 49.47 µM 0.640587899275381 0.250356866248317 no 828 0.260895231781794 292 17161528
SGTC_1516 st013856 110 µM 0.640115627803404 0.25052321297744 no 829 0.26104871484807 287 5281404 A mutagen and neurotoxin.
SGTC_1525 8-methoxypsoralen 92.5 µM 0.64004852349078 0.250546853674119 no 830 0.261070526782009 310 4114 Related to psoralen; DNA damaging agent.
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.638774777869718 0.250995815415545 no 831 0.26148472926517 287 5379071
SGTC_1073 triclabendazole 3.09 µM 0.638557930019894 0.251072290948488 no 832 0.261555278445823 282 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2681 menadione 3.18 µM 0.636503073385928 0.251797586806603 no 833 0.26222428921142 302 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1988 st071872 53.4 µM 0.635985723333906 0.251980368280275 no 834 0.262392863700119 271 16414116
SGTC_2642 cholecalciferol 100 µM 0.63594630952817 0.251994296177046 no 835 0.262405708656491 290 9821465 A vitamin D precursor, similar to steriods.
SGTC_2787 5284540 71.43 µM 0.634695833303611 0.252436395396979 no 836 0.262813405852997 304 736958
SGTC_2186 6124449 200 µM 0.634396751775369 0.252542194623137 no 837 0.262910964447993 281 3834182 YLR033W RSC58
SGTC_1103 duloxetine 36.1 µM 0.63424693328543 0.252595201262022 no 838 0.262959841297569 293 60835 A selective serotonin reuptake inhibitor.
SGTC_1272 0839-0021 27 µM 0.633522709938724 0.252851518244869 no 839 0.263196177719105 306 5027250
SGTC_1399 3562-5772 25 µM 0.633132603888494 0.252989641216365 no 840 0.263323526308952 295 23847490
SGTC_1233 0325-0408 14.2 µM 0.633071145199367 0.253011405218141 no 841 0.26334359212559 300 12874
SGTC_1254 0550-0035 264 µM 0.63206928651707 0.253366326377682 no 842 0.263670801789274 290 15121435
SGTC_1335 1486-0900 202 µM 0.63074683250296 0.253835222916837 no 843 0.264103036064649 285 X1335
SGTC_2453 5731132 22.18 µM 0.630441060287115 0.253943703990738 no 844 0.264203026799872 305 1362040
SGTC_2282 7944268 200 µM 0.629533793840819 0.254265724761744 no 845 0.264499825918155 297 2970414
SGTC_3165 9101544 49.47 µM 0.62940595284734 0.254311117229628 no 846 0.264541660886744 299 5002184
SGTC_1672 st016598 6.51 µM 0.629113690206762 0.254414906803495 no 847 0.264637314201963 312 4665860 YNL267W PIK1
SGTC_3302 9125395 16.351 µM 0.628948837904345 0.254473459657221 no 848 0.264691275723946 279 17599668
SGTC_2516 gossypol 71.55 µM 0.627341000296799 0.255044907464184 no 849 0.265217866555462 300 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_748 act1.228 77.9 µM 0.625509800092215 0.255696558177164 no 850 0.265818259213514 279 4421505 YNR035C ARC35
SGTC_2050 5263056 171 µM 0.625496106953087 0.25570143428893 no 851 0.265822751354436 280 763468 YGL055W OLE1
SGTC_1652 st011932 78 µM 0.624690933746545 0.255988240924199 no 852 0.266086962324601 289 1551076
SGTC_83 0170-0301 39.027 µM 0.623717091614988 0.256335352377618 no 853 0.266406698219272 292 3089716
SGTC_2515 chrysin 20.77 µM 0.623525958726001 0.256403507622215 no 854 0.266469474575068 292 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1283 0922-0125 16.4 µM 0.622103444469082 0.256911052299929 no 855 0.266936925106173 278 3360884
SGTC_3070 9117005 49.47 µM 0.621944336189637 0.256967853681655 no 856 0.266989235211941 301 8779016
SGTC_1176 0848-0131 83.3 µM 0.621566914466347 0.257102618712947 no 857 0.267113341036562 303 6769040
SGTC_554 4483-2211 187 µM 0.620075654050155 0.25763545864146 no 858 0.267603989953189 292 747107
SGTC_1366 1683-0113 21.9 µM 0.619175774799283 0.257957270271739 no 859 0.267900284491561 293 708623
SGTC_1265 0819-1001 68.8 µM 0.617159390279942 0.258679118954781 no 860 0.268564799276002 313 3106768
SGTC_1954 st077032 68.9 µM 0.616553668122774 0.258896166452124 no 861 0.268764581294154 322 698907
SGTC_2896 9052656 71.43 µM 0.61643601508326 0.258938335811316 no 862 0.268803394807637 300 6469436
SGTC_2634 4'-methoxyflavone 100 µM 0.615455428916677 0.259289936973025 no 863 0.26912699778883 295 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_2747 doxorubicin 7.63 µM 0.61523372359138 0.259369466310763 no 864 0.26920018978905 250 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3353 9151644 39.2805 µM 0.615134893787433 0.259404922243534 no 865 0.269232819877404 300 4909158
SGTC_553 k007-0256 45.7 µM 0.614403597258875 0.259667358140746 no 866 0.269474329632399 300 6287000
SGTC_1721 st082152 9.2685 µM 0.614210421380926 0.259736704858007 no 867 0.269538143847556 306 5296051
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.613242583083861 0.260084285500083 no 868 0.269857976007343 326 6708760
SGTC_990 3985-0011 41.3 µM 0.610867854635672 0.260938138776858 no 869 0.270643533695805 302 5399565 YGL099W LSG1
SGTC_2798 7813637 45.45 µM 0.610714493946679 0.260993330395983 no 870 0.27069430448271 299 956368
SGTC_2602 kawain 100 µM 0.610247363432721 0.261161478835024 no 871 0.270848979564579 292 5369129
SGTC_2211 7117706 200 µM 0.610070564854798 0.261225133824109 no 872 0.270907532170225 292 822771
SGTC_2865 9030313 51.95 µM 0.60860894329398 0.261751684813503 no 873 0.271391837570174 296 42562754
SGTC_3086 9117350 49.47 µM 0.608570992279089 0.261765363963092 no 874 0.271404418307225 278 2679265
SGTC_1244 0416-0015 52.5 µM 0.60851286066994 0.261786317762778 no 875 0.271423689461713 298 96201
SGTC_921 1561-0023 372 µM 0.607008396989048 0.262328907581898 no 876 0.271922669789552 294 24050882
SGTC_2620 irigenin 100 µM 0.602944311550512 0.263797507481043 no 877 0.273272868222717 301 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_27 0485-0001 32.618 µM 0.602817836955254 0.263843277575877 no 878 0.273314939705034 306 2054479
SGTC_1234 0326-0494 15.5 µM 0.600981051808219 0.264508450787837 no 879 0.273926303399275 321 1547813
SGTC_3289 9119912 71.43 µM 0.599563457405481 0.265022401081662 no 880 0.274398603530547 310 17014829
SGTC_52 0329-0193 875 nM 0.599411315004765 0.265077590596622 no 881 0.274449316710283 334 3739292
SGTC_721 1187-1332 279 µM 0.598557896592328 0.265387275517795 no 882 0.274733869877116 313 25730
SGTC_940 3232-1287 54.8 µM 0.597608013268032 0.265732181009864 no 883 0.275050758065201 315 1585493 YIL048W NEO1
SGTC_3280 9140961 49.47 µM 0.597088076316913 0.265921067872146 no 884 0.275224289137189 322 4901226
SGTC_1994 st072947 40.9 µM 0.597056326115964 0.265932604543158 no 885 0.275234887641776 319 5286565 YDL195W SEC31
SGTC_983 1491-0821 12.2 µM 0.596951887360535 0.265970554928495 no 886 0.275269751661429 288 46495113
SGTC_2904 7225135 42.03 µM 0.595941903814054 0.266337698745578 no 887 0.275607019136081 335 4446116
SGTC_1763 st044482 94.5 µM 0.59343090559313 0.267251593450952 no 888 0.276446405400895 313 88505
SGTC_318 1488-0629 67.2 µM 0.589146609802074 0.268814536680622 no 889 0.27788146440704 331 3662576
SGTC_2375 9072683 200 µM 0.588522323625531 0.269042663570273 no 890 0.278090877185572 309 16798029
SGTC_862 0452-0056 10.2 µM 0.584099185367437 0.270661746285174 no 891 0.279576791434589 304 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_548 1436-0017 110 µM 0.583755400796789 0.270787791576092 no 892 0.279692444065212 311 9677137
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM 0.583749025160754 0.270790129418157 no 893 0.279694589113362 319 688788
SGTC_1313 1220-0047 237 µM 0.583331354831919 0.270943304283076 no 894 0.279835129418885 305 3528706
SGTC_366 0181-0206 4.31 µM 0.58256827585285 0.271223264630743 no 895 0.280091983396859 315 274874
SGTC_245 methotrexate 289.6 µM 0.581287446098719 0.271693502639549 no 896 0.280523370050521 298 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_3222 9128301 49.47 µM 0.581262792944184 0.271702557665971 no 897 0.280531676447595 296 4911358
SGTC_2438 5259590 200 µM 0.58098562226684 0.271804371924856 no 898 0.280625071864312 314 1201127
SGTC_2004 4023728 41.89 µM 0.580940180409844 0.271821066082691 no 899 0.280640385385271 330 360084 YDR527W RBA50
SGTC_1854 st056233 32.9 µM 0.580702757290395 0.27190829746525 no 900 0.280720401539279 315 5393174
SGTC_1269 0831-0796 3.05 µM 0.579456087824048 0.272366563415808 no 901 0.281140734097419 314 927758
SGTC_2110 5483698 200 µM 0.57937641406046 0.272395863906675 no 902 0.281167607585104 303 2848765 YHR062C RPP1
SGTC_2422 chlorphenesin carbamate 384.24 µM 0.579204724151362 0.272459009192888 no 903 0.281225521789445 301 2724 A muscle relaxant with antifungal properties.
SGTC_736 0958-0254 92.6 µM 0.577701024816481 0.273012360433631 no 904 0.281732993574954 332 6812352
SGTC_85 0868-0259 160.055 µM 0.577589852794098 0.273053293097254 no 905 0.281770529673312 304 83173
SGTC_1097 itavastatin 7.23 µM 0.57749780071645 0.273087188249797 no 906 0.28180161194172 312 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1501 4491-0275 38.4 µM 0.576233918073011 0.273552782269434 no 907 0.28222854107598 323 5104718
SGTC_81 0411-0046 9.971 µM 0.574140547972519 0.274324809310359 no 908 0.282936348249395 298 12925265
SGTC_3205 9113483 49.47 µM 0.572293958514004 0.275006716348171 no 909 0.283561420999058 338 17018033
SGTC_1179 1021-1431 9.29 µM 0.572210460902829 0.275037569999499 no 910 0.283589700669671 333 2840958
SGTC_2791 5663188 71.43 µM 0.571708400531678 0.275223124969713 no 911 0.283759771166488 337 54690634
SGTC_676 falcarinol 140 µM 0.57072847403764 0.27558547047089 no 912 0.284091857093278 337 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_1218 1348-1416 30.7 µM 0.570553889054499 0.275650051029409 no 913 0.284151041459291 302 6787668
SGTC_252 miconazole 1.30953 nM 0.569950105688651 0.275873453281293 no 914 0.284355769660994 307 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1830 st055982 50.3 µM 0.569734920045563 0.275953094321501 no 915 0.284428750894478 342 455313 An antimicrobial agent.
SGTC_670 4204-0025 119 µM 0.569046394249534 0.276207996232788 no 916 0.284662327798826 329 719039
SGTC_1302 1159-0335 255 µM 0.568628276782845 0.276362845557862 no 917 0.284804215501509 314 649284
SGTC_798 1287-0182 476 µM 0.567888422110233 0.276636954187155 no 918 0.285055367029473 340 1649755
SGTC_2176 5809774 33.9695 µM 0.567848113830847 0.276651891821101 no 919 0.28506905313569 305 2870539
SGTC_111 0083-0039 52.457 µM 0.566996099424863 0.276967727823001 no 920 0.285358415847068 313 759313
SGTC_3067 9117431 49.47 µM 0.566924697427295 0.276994204077085 no 921 0.285382671877549 334 17150885
SGTC_2652 actinonin 100 µM 0.565240381295532 0.277619116854748 no 922 0.285955136861222 314 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.563158974905665 0.278392307786089 no 923 0.286663317923405 314 97141
SGTC_1383 3049-0032 20.7 µM 0.562878489880404 0.278496581209869 no 924 0.286758814152014 346 712864
SGTC_588 3970-1144 52.9 µM 0.561175863991751 0.279129959288044 no 925 0.287338827483763 306 1888707
SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.560989162012207 0.279199455145747 no 926 0.287402462782369 314 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_3007 9078383 71.4286 µM 0.559059497646605 0.279918224081069 no 927 0.288060557651041 313 6496995
SGTC_192 3455-0609 60.9 µM 0.556297014299337 0.280948763865694 no 928 0.289003913949937 302 3769639
SGTC_3278 9139605 49.47 µM 0.555943721949457 0.281080691115985 no 929 0.289124663966788 322 7958859
SGTC_1311 1190-0148 100 µM 0.555320717574606 0.281313407751531 no 930 0.289337655287019 338 1961333
SGTC_506 n9-isopropylolomoucine 153 µM 0.554059780435192 0.281784701788921 no 931 0.289768967090153 317 6610355
SGTC_2737 bleomycin 30.5 nM 0.551890633658984 0.282596342014669 no 932 0.29051164297117 314 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_1190 1486-1332 13 µM 0.551249513469298 0.282836448058152 no 933 0.290731321144009 328 4150046
SGTC_348 k064-0012 10.7 µM 0.551065999454708 0.282905193959775 no 934 0.290794216043291 324 5066323
SGTC_186 3455-3465 67.277 µM 0.550046135098708 0.283287389902999 no 935 0.291143865240481 322 755278
SGTC_838 0109-0203 71.4 µM 0.548951357714625 0.283697935013212 no 936 0.2915194158778 297 759422
SGTC_2212 7123476 200 µM 0.548546462855997 0.283849844062849 no 937 0.291658367551829 304 1085715
SGTC_965 1291-5240 308 µM 0.547352204735931 0.284298134243617 no 938 0.29206839234973 335 2834598
SGTC_493 zm226600 134 µM 0.547030368847303 0.284419000048711 no 939 0.292178934186719 333 5240098 A potassium channel opener. YCR052W RSC6
SGTC_3143 9086658 49.47 µM 0.546663737250289 0.284556718836388 no 940 0.292304885840629 329 25236626
SGTC_2852 9023854 51.95 µM 0.546533968609686 0.284605471800727 no 941 0.29234947226786 353 19798528
SGTC_500 h-89 112 µM 0.545912435885218 0.284839031590925 no 942 0.292563064795976 344 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_1850 st056238 17 µM 0.54507497415404 0.285153877808766 no 943 0.29285097692433 339 5393177
SGTC_537 1334-0398 209 µM 0.544777504111121 0.285265752461317 no 944 0.292953276209464 340 5846986
SGTC_742 0kpi-0133 140 µM 0.543835376948293 0.285620212282537 no 945 0.293277381018455 336 2728852
SGTC_154 3389-1638 511.116 µM 0.543480083219992 0.28575394009642 no 946 0.293399650130316 355 5238686
SGTC_2379 9035213 200 µM 0.543017260201229 0.285928185151482 no 947 0.293558959276955 317 646551
SGTC_3155 9099265 49.47 µM 0.540771467541672 0.286774404558693 no 948 0.294332555748598 346 25236499
SGTC_2115 tiliquinol 12.7705 µM 0.54076862484831 0.286775476443421 no 949 0.29433353555264 345 71208 A bioactive hydroxyquinoline.
SGTC_2895 9054447 58.44 µM 0.540655217052934 0.286818240284609 no 950 0.294372625561517 334 2697450
SGTC_2215 7188065 200 µM 0.538465086783329 0.287644687362247 no 951 0.295128001117887 331 940217
SGTC_2096 5468907 200 µM 0.537047721143147 0.288180130374742 no 952 0.295617325524115 319 759785
SGTC_2055 5235184 200 µM 0.536870275095328 0.288247197873478 no 953 0.295678612391804 355 2836034
SGTC_3093 9117344 49.47 µM 0.53642095033259 0.288417057550983 no 954 0.295833827683611 312 24824913
SGTC_2227 7312221 64.1025 µM 0.534082533695948 0.289301817527784 no 955 0.296642216716403 345 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_1066 ketoconazole 628 nM 0.533712278755264 0.289442023542564 no 956 0.296770306319059 354 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.53270979812848 0.289821797261109 no 957 0.297117241257528 331 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_307 1501-1223 22.3 µM 0.532579152716799 0.289871307393434 no 958 0.297162468213035 335 2830329
SGTC_1201 1889-3372 45.9 µM 0.531939164523388 0.290113898274869 no 959 0.297384065403633 309 5392199
SGTC_3335 9143315 29.6265 µM 0.530074963790204 0.290821075007438 no 960 0.298029978384814 313 4899691
SGTC_2594 a-mangostin 100 µM 0.52882025355334 0.291297497348286 no 961 0.298465073199603 337 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1370 2001-0092 44.6 µM 0.526966983467223 0.292001862703252 no 962 0.299108258265488 335 790957
SGTC_704 1310-0270 142 µM 0.526945371244917 0.292010081454483 no 963 0.299115762587047 346 5718033
SGTC_1619 st003326 88.7 µM 0.526923999108682 0.292018209011078 no 964 0.299123183628569 301 2849032
SGTC_570 0987-0065 62.6 µM 0.526016053758115 0.292363586523979 no 965 0.29943852642438 337 3104428
SGTC_485 niflumic acid 177 µM 0.523892544488817 0.293172098721176 no 966 0.300176640316049 336 4488 A COX2 inhibitor.
SGTC_1548 st061468 90.8 µM 0.523528059447539 0.293310978184278 no 967 0.30030341491956 336 390799
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.522368340962121 0.293753067570329 no 968 0.300706947240391 367 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_818 4072-2707 53.5 µM 0.521220299676175 0.294191009010841 no 969 0.301106657250746 328 882871
SGTC_1909 st060837 51.5 µM 0.519840780497674 0.29471765060176 no 970 0.301587276648232 362 678937
SGTC_1720 st037298 9.481 µM 0.518766235216938 0.295128167134237 no 971 0.3019618831781 358 597396
SGTC_946 3434-1334 87.4 µM 0.517567188565428 0.295586558444064 no 972 0.302380139776215 323 4047976
SGTC_1801 st050089 28.441 µM 0.517119368878176 0.29575784224505 no 973 0.302536416779427 313 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2009 4012297 12.05 µM 0.516331265995749 0.296059389568313 no 974 0.302811531331459 321 45595307
SGTC_2145 5634607 200 µM 0.516245362954909 0.296092266687087 no 975 0.302841525527057 338 308662
SGTC_1345 1488-0192 31.4 µM 0.516213074261523 0.296104624764429 no 976 0.302852799900154 340 658348
SGTC_37 0566-0070 1.56 µM 0.514919859157578 0.296599780478646 no 977 0.303304511422025 344 1626686
SGTC_1015 4130-4525 82 µM 0.512751064272341 0.297431034916883 no 978 0.30406273236263 330 1363237
SGTC_321 4534-3890 65.3 µM 0.511229756288269 0.298014755122765 no 979 0.304595092422764 354 699746
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 0.511075967968323 0.298073792173819 no 980 0.304648931521897 333 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_97 0535-0701 19.132 µM 0.509449225154153 0.298698600607953 no 981 0.305218689942559 333 2832013 YGL099W LSG1
SGTC_1527 coumarin 137 µM 0.50930665578765 0.298753387810558 no 982 0.305268646670363 377 323 A hepatotoxic, DNA x-linker.
SGTC_3027 9089541 49.47 µM 0.507182585872321 0.29957017538268 no 983 0.306013356259176 327 9943819
SGTC_3217 9129673 49.47 µM 0.506537343701906 0.299818496370446 no 984 0.306239740479637 326 17248312
SGTC_1136 pergolide 1.05886 µM 0.505888185589997 0.300068418410565 no 985 0.306467573292514 335 47811 A dopamine receptor agonist.
SGTC_3313 9133968 57.047 µM 0.505442166490847 0.300240187729196 no 986 0.30662415447287 321 1494643
SGTC_2683 piperine 63.03 µM 0.504926798344105 0.300438719846647 no 987 0.306805125558615 350 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_650 1328-0195 38 µM 0.504890859454948 0.300452566576692 no 988 0.306817747226073 346 2780821
SGTC_1033 k072-0102 21.3 µM 0.504379298451999 0.300649694820463 no 989 0.306997431273834 333 5965931
SGTC_2678 equilin 100 µM 0.504002665934591 0.300794866147694 no 990 0.307129751791871 308 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_1717 st033143 58.0435 µM 0.500799260115631 0.302030880833417 no 991 0.308256203200974 363 674616
SGTC_2024 5144227 134 µM 0.497074607322954 0.303470876129414 no 992 0.309568220188441 337 3475211
SGTC_629 3448-6466 76.7 µM 0.495942671244068 0.303909103006288 no 993 0.309967429472921 352 573744
SGTC_869 0564-0080 44.1 µM 0.495539022971403 0.304065442893754 no 994 0.310109841699268 318 6843321
SGTC_848 0368-0089 85.6 µM 0.495450956526232 0.304099557298863 no 995 0.310140916443678 351 762535
SGTC_2565 isoliquiritigenin 100 µM 0.495046019988087 0.30425644000164 no 996 0.310283818044601 305 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_455 paf C-16 10 µM 0.492670298970621 0.3051775798323 no 997 0.311122783561043 334 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_3015 9080845 49.47 µM 0.492027437445771 0.305427049566467 no 998 0.311349973656703 342 5296973
SGTC_3149 9097855 49.47 µM 0.491865981400775 0.305489718627745 no 999 0.311407044229539 319 25236625 YMR079W SEC14
SGTC_1963 st076565 50.3 µM 0.491634054370633 0.305579750931285 no 1000 0.311489032420317 359 4914280
SGTC_3045 9092950 49.47 µM 0.491618948244847 0.305585615421928 no 1001 0.311494372889447 328 44120432
SGTC_2657 nystatin 74.44 µM 0.491220015626802 0.305740506838688 no 1002 0.311635421901572 336 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3242 9133940 49.47 µM 0.489931379818684 0.306241075902289 no 1003 0.312091228494563 348 17248444
SGTC_3248 9135562 49.47 µM 0.489527154087053 0.306398171525785 no 1004 0.31223426752709 329 17650701
SGTC_1397 3532-0190 20.1 µM 0.487903063143023 0.307029706063457 no 1005 0.312809252366163 322 5322280
SGTC_1191 1487-1166 10.6 µM 0.486713747378989 0.307492540005646 no 1006 0.313230600795056 354 3955771
SGTC_80 0159-0065 512.242 µM 0.486523706310293 0.307566524793348 no 1007 0.313297950786298 331 1548079
SGTC_2583 asiatic acid 100 µM 0.48632322343657 0.30764458315992 no 1008 0.313369008072326 360 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_705 1124-0212 310 µM 0.484960753450269 0.308175293860116 no 1009 0.313852092692383 384 9554485
SGTC_1985 st071382 65.5 µM 0.484615690143196 0.308309767000561 no 1010 0.313974490878659 342 6123237
SGTC_775 4577-0580 57.3 µM 0.482299247575358 0.309213163242817 no 1011 0.314796690854664 359 2006902
SGTC_2698 st077697 67.5 µM 0.479876750320454 0.310159155496999 no 1012 0.315657517082514 339 3154499
SGTC_2386 9075165 157.42 µM 0.479468955912343 0.310318524255076 no 1013 0.315802524019733 341 16452277
SGTC_478 N-arachidonylglycine 10 µM 0.478835101756892 0.31056630937263 no 1014 0.316027971450727 315 5283389
SGTC_1561 5-methoxyflavone 52.9 µM 0.47828244401152 0.310782423501334 no 1015 0.316224595025334 345 94525
SGTC_2401 5128683 200 µM 0.477846160559209 0.310953076152032 no 1016 0.3163798518803 358 708373
SGTC_2707 st078556 66.6 µM 0.476891540422009 0.311326618435104 no 1017 0.316719678119918 332 17250899
SGTC_784 4579-0127 173 µM 0.476684330946103 0.311407725062416 no 1018 0.316793461118982 362 1948547
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.47560216554672 0.311831458544013 no 1019 0.317178916153743 339 75037 A free radical scavenger.
SGTC_1984 st072354 53.1 µM 0.47409939221513 0.312420298831988 no 1020 0.317714516002021 363 5762938
SGTC_975 1335-0046 28.5 µM 0.473581612989196 0.312623294334603 no 1021 0.317899144925894 358 16486740
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.473446190970002 0.312676395960429 no 1022 0.31794744097359 362 689007
SGTC_2557 derrustone 83.84 µM 0.472257099496926 0.313142828883053 no 1023 0.318371643886256 361 629853 An antioxidant.
SGTC_2739 tacrine 100.86 µM 0.47129542875627 0.313520272619417 no 1024 0.318714889800625 335 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_1664 st014217 9.02 µM 0.470645405342105 0.313775509350473 no 1025 0.318946988630143 368 3982782
SGTC_3024 9090631 49.47 µM 0.469149439646287 0.314363250399263 no 1026 0.319481411185372 333 25236383
SGTC_271 rotenone 740 µM 0.466577589550717 0.315374789408681 no 1027 0.320401061879656 369 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1932 st074806 40.9 µM 0.465658178370656 0.315736741243146 no 1028 0.320730096160299 396 17251235
SGTC_1452 4194-0072 190 µM 0.464737516883003 0.316099362459979 no 1029 0.32105971908226 351 1343545
SGTC_3311 9131146 2.8755 µM 0.463040356258811 0.316768287276018 no 1030 0.321667720256012 349 4900406 YPR165W RHO1
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 0.461948025479475 0.317199139627064 no 1031 0.322059296408564 365 551469
SGTC_3266 9136860 49.47 µM 0.461178742866461 0.317502719616401 no 1032 0.322335185647715 363 4871271 YPR165W RHO1
SGTC_526 4469-0568 170 µM 0.461062409163931 0.317548638774156 no 1033 0.322376915142204 357 2901964
SGTC_2995 9067767 71.4286 µM 0.46073280571208 0.317678754861369 no 1034 0.322495157740508 344 11673567
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.459280590768017 0.318252307331706 no 1035 0.323016341942437 335 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_345 1362-0200 395 µM 0.459136914658447 0.31830907595299 no 1036 0.323067924658377 333 1419823
SGTC_3139 9095020 49.47 µM 0.457905046650038 0.318795980807172 no 1037 0.323510330508769 324 25236292
SGTC_3319 9138450 16.7555 µM 0.456986574845691 0.319159217231846 no 1038 0.323840347555801 366 2029690
SGTC_1811 st050069 61.5 µM 0.456703947202461 0.319271025526989 no 1039 0.323941926670587 365 3877702
SGTC_1606 st000094 49.2 µM 0.456052373638521 0.319528852492815 no 1040 0.324176158475674 352 1242210
SGTC_2351 9026858 72.31 µM 0.456017440828576 0.319542677834203 no 1041 0.324188718310989 366 1409300
SGTC_1808 st050063 61.5 µM 0.4551689113963 0.319878576921478 no 1042 0.324493862264338 389 4011993
SGTC_1072 oxiconazole 14.9 nM 0.455129042846849 0.319894362932217 no 1043 0.324508202495424 325 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_3171 9103192 49.47 µM 0.454848977967929 0.320005264224488 no 1044 0.324608945750471 363 13018434
SGTC_143 4032-1194 15.74 µM 0.454786303323702 0.320030084602131 no 1045 0.324631492454469 344 1806963
SGTC_999 SEC7.066 22.7 µM 0.454552503756605 0.32012268088287 no 1046 0.324715605656025 360 740511 YDR170C SEC7
SGTC_503 tyrphostin 8 294 µM 0.454549789544001 0.320123755912137 no 1047 0.324716582190709 396 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_2765 myclobutanil 7.74 µM 0.454284345932728 0.320228898541152 no 1048 0.324812090806387 375 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2945 9067681 61.76 µM 0.453104558514428 0.320696388750003 no 1049 0.325236726512811 382 16456930
SGTC_2190 6049624 200 µM 0.452749012764754 0.320837329412541 no 1050 0.32536474107929 361 2265554
SGTC_1948 st076329 66.6 µM 0.452021586888108 0.321125766244181 no 1051 0.325626715619847 365 24208413
SGTC_2704 st078022 71.1 µM 0.450929813421435 0.321558875704119 no 1052 0.326020067649242 366 54697681
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.45078367363941 0.321616868174989 no 1053 0.32607273465271 353 390807
SGTC_1896 st058441 89 µM 0.450492633241973 0.321732374328015 no 1054 0.326177632413775 337 688759
SGTC_2132 5317594 122.667 µM 0.44996017916586 0.321943735710141 no 1055 0.326369576900922 389 794577
SGTC_3144 9087057 49.47 µM 0.449170379096134 0.322257358493068 no 1056 0.326654376796558 392 17249618
SGTC_1437 4092-1038 11.6 µM 0.448521191203825 0.322515240189927 no 1057 0.326888547972406 363 3977136
SGTC_2214 7179297 48.276 µM 0.448423927046602 0.322553884509026 no 1058 0.326923638393707 354 769744
SGTC_3202 9113761 49.47 µM 0.446377920233513 0.323367233484111 no 1059 0.327662139655464 368 4798415
SGTC_134 0269-0018 6.916 µM 0.445260745763331 0.323811700664032 no 1060 0.328065666077824 363 4378915
SGTC_2964 9083345 53.42 µM 0.444641590897319 0.324058139355761 no 1061 0.328289392977845 349 17741579
SGTC_1753 st043925 64 µM 0.44398899118606 0.324317973394676 no 1062 0.328525271598944 353 670181
SGTC_551 k048-0028 34.9 µM 0.443063966964392 0.324686420454024 no 1063 0.328859733672983 365 6836383
SGTC_2005 4024620 188 µM 0.442275342688063 0.325000673497603 no 1064 0.32914498574123 370 236743
SGTC_1900 st060200 72.8 µM 0.442048071298793 0.325091260317307 no 1065 0.329227210201527 350 688945
SGTC_55 0767-0285 6.563 µM 0.441321598154245 0.325380890473614 no 1066 0.329490096133481 373 3116166
SGTC_3097 9117246 49.47 µM 0.441037642703275 0.325494126457049 no 1067 0.329592872877139 336 16423892
SGTC_2976 9009005 19.48 µM 0.440956107776082 0.325526643998268 no 1068 0.329622386555453 346 2993148
SGTC_1039 k821-0043 94 µM 0.439823772923627 0.325978375941241 no 1069 0.330032374106128 374 15992768
SGTC_2179 6298986 200 µM 0.439806300987412 0.325985348172419 no 1070 0.330038701818538 354 738374
SGTC_790 1575-0012 79.1 µM 0.438967540500116 0.326320129718166 no 1071 0.330342528132285 393 378741 YLR208W SEC13
SGTC_1784 st039334 36.3 µM 0.438857938120538 0.326363886586466 no 1072 0.33038223794607 369 3496984
SGTC_2301 7769476 200 µM 0.438419431586223 0.326538976694099 no 1073 0.330541131455468 357 977820
SGTC_1968 st069590 43.6 µM 0.438104872299572 0.326664599779433 no 1074 0.330655131310385 364 6384066
SGTC_1197 1601-0112 267 µM 0.437975419143366 0.326716304184955 no 1075 0.330702051167063 347 7350313
SGTC_2576 guaiol 23.12 µM 0.435820647055586 0.32757742181345 no 1076 0.331483431178475 345 227829
SGTC_1604 st002052 72.4 µM 0.435505784748871 0.327703328101178 no 1077 0.331597670512199 328 6254834 YHR062C RPP1
SGTC_3208 9114115 49.47 µM 0.434763278474669 0.328000317059213 no 1078 0.331867130992455 383 650895
SGTC_2546 rhodinyl acetate 100 µM 0.434330248125148 0.328173571532254 no 1079 0.332024320767326 349 6708682
SGTC_2287 7945887 168.79 µM 0.429352851434762 0.330167663576042 no 1080 0.333833230066301 373 1245853
SGTC_507 nimesulide 162 µM 0.427887666271129 0.330755583487096 no 1081 0.334366453552865 373 4495 A COX2 inhibitor.
SGTC_2046 4110841 106 µM 0.427350445583198 0.330971253298617 no 1082 0.334562047615604 372 44119630 YMR134W ERG29
SGTC_2026 5148700 152 µM 0.427135168382586 0.331057693108831 no 1083 0.334640439449311 346 79838
SGTC_2437 5741531 144.16 µM 0.426539034390312 0.331297104545028 no 1084 0.334857555489965 367 2262990
SGTC_2833 9001315 45.46 µM 0.424417475444004 0.332149695861934 no 1085 0.335630689107893 347 2989378
SGTC_1783 st039459 87.517 µM 0.424378131180794 0.332165515374822 no 1086 0.335645033440077 426 729761
SGTC_2229 7354935 190 µM 0.423870729463335 0.332369557882582 no 1087 0.335830046001764 383 318112
SGTC_847 0342-0274 5.54 µM 0.423715208819252 0.332432107674623 no 1088 0.335886761057446 388 18097
SGTC_2658 polymyxin b sulfate 77.05 µM 0.420873887156646 0.333575696040484 no 1089 0.336923587101396 362 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_3298 9116858 71.43 µM 0.420734994840096 0.33363163783907 no 1090 0.336974302125959 391 2506942
SGTC_482 fipronil 114 µM 0.420457136014119 0.333743562420221 no 1091 0.337075768160103 366 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_1349 flufenamic acid 69 µM 0.41970526771656 0.334046497374451 no 1092 0.337350388211679 373 3371 A non-steroidal anti-inflammatory.
SGTC_744 1594-0068 283 µM 0.419307383725705 0.334206852430092 no 1093 0.33749575049983 363 668392
SGTC_3291 9121177 71.43 µM 0.416252184670044 0.33543916415991 no 1094 0.338612738659089 342 17015612
SGTC_215 1287-0124 461.5 µM 0.415933906712983 0.335567643450138 no 1095 0.33872918374913 379 5560863
SGTC_262 fenpropimorph 62.5 µM 0.415687385161001 0.335667170041147 no 1096 0.338819386654756 380 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_234 nsc-17383 10.7 µM 0.415582541373309 0.335709501456861 no 1097 0.338857752083509 366 408974
SGTC_1768 st044301 37.178 µM 0.414305575632647 0.336225252542658 no 1098 0.339325165512238 411 3931349
SGTC_2332 7982454 138.89 µM 0.414218934659848 0.336260256971338 no 1099 0.339356888059217 388 2981748
SGTC_360 0957-0399 1.01 µM 0.413459447519279 0.336567163447454 no 1100 0.339635013823051 353 6752301 YPR165W RHO1
SGTC_745 0469-0705 296 µM 0.412908072123601 0.336790040834197 no 1101 0.339836983368846 403 3486736
SGTC_1849 st056239 19.2 µM 0.412861524785586 0.336808858860219 no 1102 0.339854035826801 356 5393181
SGTC_1578 josamycin 24.2 µM 0.41190629676883 0.337195125899202 no 1103 0.340204052665288 349 5282165 A P450 substrate.
SGTC_2484 5809818 12.04 µM 0.411816326484445 0.337231516176166 no 1104 0.340237026885116 346 2870548
SGTC_510 ag-490 170 µM 0.410811450672329 0.337638061675275 no 1105 0.340605398082083 355 5328779
SGTC_2629 bisabolol 100 µM 0.410153791712785 0.33790423530659 no 1106 0.340846567570815 402 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM 0.408806266375778 0.338449870973373 no 1107 0.34134092043507 396 688798
SGTC_2237 6667747 47.222 µM 0.407578081178621 0.338947479466497 no 1108 0.341791729503561 408 729940 YDL015C TSC13
SGTC_2300 7976697 71.57 µM 0.406809524812534 0.339259008946088 no 1109 0.342073945283533 356 2236109
SGTC_528 3492-0019 172 µM 0.406744558411715 0.339285347708138 no 1110 0.342097805152183 371 2869262
SGTC_1487 3970-0795 2.82 µM 0.404437353741764 0.34022124590934 no 1111 0.342945568258345 360 3765103
SGTC_950 1165-0508 94.1 µM 0.404421128831577 0.340227830902839 no 1112 0.342951532773009 373 6148369
SGTC_394 menadione 8.33 µM 0.404008239874486 0.340395421172071 no 1113 0.343103329969007 387 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1115 galangin 695.678 nM 0.40290457312151 0.340843550558772 no 1114 0.343509213486379 406 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_3256 9138902 49.47 µM 0.402814551389249 0.340880112619476 no 1115 0.343542327768185 392 17228773
SGTC_709 3807-1509 243 µM 0.402290087496635 0.341093151789992 no 1116 0.343735274443336 392 1886677 YPL242C IQG1
SGTC_1690 st023502 41.2 µM 0.401424121107486 0.341445021411292 no 1117 0.344053946637731 409 24207482
SGTC_57 miconazole 162.5 nM 0.401099655867781 0.341576897455551 no 1118 0.344173377103116 378 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_3307 9126885 69.2785 µM 0.400463514461796 0.341835507658731 no 1119 0.344407575683179 359 24824909
SGTC_2102 5377816 72.7585 µM 0.399263203634101 0.342323671447228 no 1120 0.344849638454573 400 1379702
SGTC_21 0849-0113 22.993 µM 0.399024651287659 0.342420721587212 no 1121 0.344937520216414 369 1560156
SGTC_2617 dihydrotanshinone i 20.83 µM 0.398868174953274 0.342484386433256 no 1122 0.344995170036518 351 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_2336 9001819 198.65 µM 0.398012547598673 0.342832590921649 no 1123 0.345310468290323 408 2989602
SGTC_408 cantharidin 100 µM 0.396150630598079 0.343590774332735 no 1124 0.345996954634019 360 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1736 st036774 51 µM 0.396031136105748 0.343639454717758 no 1125 0.346041029414751 394 1272247
SGTC_1839 st053978 48 µM 0.395504697283487 0.343853949399247 no 1126 0.346235227843105 382 3788398
SGTC_2113 5491891 107.031 µM 0.395429063057041 0.343884770291514 no 1127 0.346263131935292 373 789979
SGTC_2367 9070478 135.38 µM 0.3952265058219 0.343967317326673 no 1128 0.346337866442253 376 572802
SGTC_1096 rimcazole 32.2 µM 0.395081872303694 0.344026263579771 no 1129 0.346391233365108 392 18528119 A dopamine reuptake inhibitor.
SGTC_487 nimodipine 119 µM 0.392904756147915 0.344914017519665 no 1130 0.347194914305281 396 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2869 9037858 32.47 µM 0.391152474435272 0.345629159328407 no 1131 0.347842267598922 361 27187042
SGTC_1421 4029-0249 71.4 µM 0.391094534094225 0.345652815389031 no 1132 0.347863680349102 389 2894095
SGTC_520 3584-0023 682 µM 0.391081631081031 0.345658083552996 no 1133 0.34786844892348 338 1340790
SGTC_247 mechlorethamine 29.705 µM 0.390131008042919 0.346046295054823 no 1134 0.348219837401233 374 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_2439 5492030 7.2 µM 0.389951704349408 0.34611953651159 no 1135 0.348286129871222 383 5722370
SGTC_3172 9105863 49.47 µM 0.388605644741533 0.346669554714343 no 1136 0.348783945235558 381 2348785
SGTC_541 4513-1321 94 µM 0.387037139135102 0.347310875260992 no 1137 0.349364356695487 374 747515
SGTC_232 clozapine 119 µM 0.385561931548949 0.347914447947503 no 1138 0.349910565713517 387 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2420 aureobasidin a 50 nM 0.385458379497187 0.347956830172771 no 1139 0.34994891848634 347 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_281 1672-3440 14.9 µM 0.384458277653459 0.348366253813506 no 1140 0.35031940687013 392 6833000
SGTC_2519 cryptotanshinone 88.04 µM 0.381661009612796 0.349512342082869 no 1141 0.351356412216067 363 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_616 4092-0450 108 µM 0.381543577942099 0.349560485939513 no 1142 0.351399970850542 389 787165
SGTC_3218 9131285 49.47 µM 0.381505049401278 0.349576282142109 no 1143 0.351414262570597 396 17156417
SGTC_226 1,3-diallylurea 8.28947 mM 0.378245892072428 0.350913434850088 no 1144 0.352623968232418 370 74537 YKL182W FAS1
SGTC_1617 st002906 78 µM 0.376885381075703 0.351472167163739 no 1145 0.353129392968207 402 5150859
SGTC_2673 kobusone 100 µM 0.376662693109185 0.351563650883859 no 1146 0.35321214542191 397 6710676 An epoxy ketone and protein crosslinker.
SGTC_1453 4237-0541 195 µM 0.376078469827249 0.351803699854853 no 1147 0.353429279989641 360 739892
SGTC_415 dibenzyl ketone 100 µM 0.37577649521451 0.351927800065156 no 1148 0.353541531690344 414 7593
SGTC_223 busulfan 5 mM 0.374446587193669 0.352474529818551 no 1149 0.354036044043008 389 2478 A DNA alkylator.
SGTC_3090 9117696 49.47 µM 0.374153327129635 0.352595131111647 no 1150 0.354145122895784 409 7923821
SGTC_2006 4011487 200 µM 0.374146501763428 0.352597938175581 no 1151 0.354147661751271 372 45595294
SGTC_1442 4112-3290 3 µM 0.373285200824025 0.352952229223099 no 1152 0.354468094889627 390 704353
SGTC_2887 9044784 58.44 µM 0.372536581017153 0.353260273166184 no 1153 0.354746690535905 394 6465546
SGTC_1688 st021091 57.6 µM 0.371805080226536 0.35356136583178 no 1154 0.355018990477524 403 3656366
SGTC_2269 7935389 174.42 µM 0.371638148577441 0.353630089332707 no 1155 0.355081140888356 400 97605
SGTC_1225 1216-0074 20.6 µM 0.369797839153233 0.354388035593477 no 1156 0.355766562699462 380 4241466
SGTC_228 caffeine 993.056 µM 0.368859987227656 0.354774519638403 no 1157 0.356116044534707 366 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_3300 9124615 50.48 µM 0.367331149846292 0.355404866201377 no 1158 0.356686010730179 376 24824903
SGTC_991 3996-0057 64.7 µM 0.365874109161125 0.356005979039989 no 1159 0.357229508376516 355 715343
SGTC_1100 amiodarone 5.07 µM 0.365872821006559 0.356006510636274 no 1160 0.357229989005521 372 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2592 piperlongumine 83.33 µM 0.365362026031116 0.356217327822043 no 1161 0.357420591808016 388 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2507 purpurin 79.67 µM 0.365176545377978 0.356293890963276 no 1162 0.357489812595929 370 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1665 st014639 11.4 µM 0.364048508638527 0.35675964928189 no 1163 0.357910893200591 396 981133 YIL048W NEO1
SGTC_2650 prasterone 100 µM 0.363347825310604 0.357049064038175 no 1164 0.358172535764481 376 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_3220 9131269 49.47 µM 0.361631175562339 0.357758467538416 no 1165 0.358813832253107 393 17722206
SGTC_178 4092-0806 87.505 µM 0.36099146481393 0.358022953123202 no 1166 0.359052913785985 377 2169044
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.360631717018278 0.358171719212108 no 1167 0.35918738796168 357 3256 An antibiotic and ribosome inhibitor.
SGTC_23 0213-0011 39.996 µM 0.360456942784756 0.358244001172246 no 1168 0.359252725086749 378 627608
SGTC_770 0389-1121 67.2 µM 0.359689550742945 0.358561434143192 no 1169 0.359539653536695 376 6753108
SGTC_2674 ligustilide 100 µM 0.358868264354501 0.358901268879916 no 1170 0.359846820868254 387 5319022 A signalling regulator.
SGTC_1037 k284-1091 78.7 µM 0.354897317849685 0.360545952408586 no 1171 0.361333258952813 364 3334711
SGTC_1683 st010134 710 nM 0.354703189670229 0.360626422740543 no 1172 0.361405980557415 378 3818134
SGTC_2919 7978188 46.38 µM 0.35467616031241 0.36063762748396 no 1173 0.361416106317557 369 2980291
SGTC_2138 5575593 77.673 µM 0.353559982044722 0.36110043213597 no 1174 0.361834334630024 407 762213
SGTC_1299 1079-1439 3.74 µM 0.353534657330666 0.36111093496745 no 1175 0.361843825633735 389 323161
SGTC_1237 0330-0133 46.1 µM 0.352460191889079 0.361556640692308 no 1176 0.362246583835816 412 X1237 YHR072W ERG7
SGTC_45 0kpi-0036 14.9 µM 0.35225709997626 0.361640907652956 no 1177 0.362322729017756 415 2795021
SGTC_2692 st077426 47.7 µM 0.352207033697451 0.36166168220038 no 1178 0.362341501187796 419 25238571
SGTC_304 1310-0298 97 µM 0.352201991298644 0.361663774520546 no 1179 0.362343391835328 409 1550234
SGTC_1774 st048371 48.465 µM 0.351991598841974 0.36175107958753 no 1180 0.362422281483433 380 4242727
SGTC_1630 st005209 31.3 µM 0.35171971163062 0.361863913355539 no 1181 0.362524238118777 409 3367314
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.349766493172643 0.362674855631774 no 1182 0.363256973587112 386 2374 Ca(2+)-ATPase inhibitor.
SGTC_2867 9039098 71.43 µM 0.349515735909196 0.362779010399997 no 1183 0.363351079643275 395 6463460
SGTC_2956 9076196 2.52 µM 0.349439187962185 0.362810807449009 no 1184 0.363379808771281 416 16423868
SGTC_2474 5321570 43.32 µM 0.347991186660254 0.363412466841999 no 1185 0.363923401182089 427 2841384
SGTC_1518 st038567 90.8 µM 0.347943960671149 0.363432095409266 no 1186 0.363941134852369 405 77966
SGTC_436 n,n-dimethylsphingosine 3.3 µM 0.34791675617567 0.363443402593438 no 1187 0.363951350452068 406 5282309
SGTC_1649 st011737 51.3 µM 0.344688609506294 0.364785980690667 no 1188 0.365164241125198 395 1761035
SGTC_2221 6807166 181.081 µM 0.343134677494861 0.365432849964231 no 1189 0.365748572093065 401 674925
SGTC_1016 4226-1401 38 µM 0.342850283239196 0.365551278833955 no 1190 0.365855547722119 382 2901613
SGTC_2537 larixol 68.93 µM 0.342687674730773 0.365618998837856 no 1191 0.365916718017519 399 6708759
SGTC_863 0466-0191 129 µM 0.342487585350587 0.365702333888344 no 1192 0.365991992597221 427 765160 YPR165W RHO1
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 0.34236626570682 0.365752865287323 no 1193 0.366037636138479 422 5393153
SGTC_513 4245-1575 41.7 µM 0.342101400710756 0.36586319350979 no 1194 0.366137291685812 394 719745
SGTC_1414 3917-0015 5.4 µM 0.341556401457383 0.366090245182628 no 1195 0.366342376245785 418 6618702
SGTC_1977 st070720 65.3 µM 0.341192506785123 0.36624187314742 no 1196 0.366479331966455 376 682188
SGTC_956 1185-0240 191 µM 0.340308314780849 0.366610386071779 no 1197 0.366812178077854 383 1416193
SGTC_2482 5981709 142.65 µM 0.33926687732196 0.367044593386237 no 1198 0.367204346278653 406 877755
SGTC_2532 xanthone 78.9 µM 0.339216727288747 0.367065506775615 no 1199 0.367223234492908 408 7020 An insecticide.
SGTC_3055 9094636 49.47 µM 0.339031597857849 0.367142712211125 no 1200 0.367292963337659 397 25236176
SGTC_2233 sulbentine 40.3845 µM 0.337524063541641 0.367771606399575 no 1201 0.367860937613999 389 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_91 0417-1751 58.384 µM 0.336124373963207 0.368355828865577 no 1202 0.368388539438307 400 6795624
SGTC_1116 jasmonic acid 1.58368 µM 0.335077227306229 0.368793101126467 no 1203 0.36878341542274 423 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_1419 3993-2473 62.6 µM 0.33082340380989 0.370571173784414 no 1204 0.370388940838406 395 704026
SGTC_1242 0402-0103 60.1 µM 0.330590248728427 0.3706687115727 no 1205 0.37047700641981 385 432868
SGTC_371 0195-0006 7.36 µM 0.330196658785197 0.370833384326993 no 1206 0.370625685648548 382 3928593
SGTC_1803 st050068 52.4 µM 0.329747432142506 0.371021363643594 no 1207 0.370795405342391 409 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_2550 chrysin dimethyl ether 71.87 µM 0.329231663871574 0.37123722532473 no 1208 0.370990295743129 393 88881 An O-methylated flavonoid and antioxidant.
SGTC_1337 1486-1011 40.3 µM 0.328662894204549 0.37147531636148 no 1209 0.371205251848804 385 X1337
SGTC_435 c-PAF 6.7 µM 0.327897422405181 0.371795825937705 no 1210 0.371494611357218 412 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_3252 9135871 49.47 µM 0.327552795279993 0.371940153284481 no 1211 0.371624909160478 410 17682838
SGTC_1193 1488-0126 41.5 µM 0.327330857164503 0.372033108889613 no 1212 0.371708828070368 384 1384710
SGTC_2444 5485484 36.41 µM 0.327168952704084 0.372100924962601 no 1213 0.371770050990199 418 6790631
SGTC_2748 diazoxide 86.69 µM 0.326825267992635 0.372244895524235 no 1214 0.371900023453587 408 3019 A potassium channel activatior.
SGTC_992 3909-8734 162 µM 0.326640082192145 0.372322477819459 no 1215 0.3719700618767 413 4288319
SGTC_2729 fluphenazine 10.66 µM 0.3244839517636 0.373226154228579 no 1216 0.372785835101852 409 3372 An atypical antipsychotic.
SGTC_1657 st012939 43.4 µM 0.323894060505533 0.373473510965491 no 1217 0.373009120420511 408 24207257
SGTC_1711 st032263 62.8 µM 0.32341064388145 0.373676258999601 no 1218 0.37319213483055 423 3958979
SGTC_3261 9137475 49.47 µM 0.32338904066169 0.373685320345182 no 1219 0.373200314159439 410 17027690
SGTC_3111 9122088 49.47 µM 0.322954462932833 0.373867616284039 no 1220 0.37336486445812 408 16876704
SGTC_1974 st069448 26.9 µM 0.322942609019976 0.373872589139096 no 1221 0.373369353196152 399 6323587 YNR016C ACC1
SGTC_1836 st055642 81 µM 0.322731524688057 0.373961144999433 no 1222 0.373449287677041 429 8571
SGTC_62 0180-0423 3.232 µM 0.32123574066456 0.374588859146047 no 1223 0.374015874557443 409 30102 YGL099W LSG1
SGTC_2591 skatole 100 µM 0.320163000811478 0.375039245277217 no 1224 0.374422384604878 423 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_694 1315-0438 43.2 µM 0.319604505065707 0.375273795301413 no 1225 0.374634079412053 409 6793154
SGTC_2892 9047358 58.44 µM 0.31910003260103 0.375485696954902 no 1226 0.374825329470888 410 6466771
SGTC_851 0394-0702 453 µM 0.318943113604406 0.375551617819463 no 1227 0.374884825157199 414 762646
SGTC_1886 st057356 49.9 µM 0.318480740441589 0.375745879530119 no 1228 0.375060150805016 392 24207747
SGTC_3003 9075612 71.4286 µM 0.31797513557143 0.37595834068851 no 1229 0.375251898884061 424 6501993
SGTC_1842 st055362 61.2 µM 0.317180022809609 0.376292532543108 no 1230 0.375553503706966 389 676032
SGTC_1057 3448-5381 134 µM 0.317101800511694 0.376325414977412 no 1231 0.375583179362602 398 5497911
SGTC_1360 1598-0022 39.8 µM 0.316636931138116 0.376520851381899 no 1232 0.375759554785922 427 761525
SGTC_2412 st077135 33.4 µM 0.31663168676464 0.376523056357193 no 1233 0.375761544694321 419 13258915
SGTC_1428 4049-0204 61.7 µM 0.31576567080881 0.376887224423727 no 1234 0.376090188323459 413 X1428
SGTC_1021 4476-0760 85.3 µM 0.315584675922405 0.376963348371927 no 1235 0.37615888527584 393 746768
SGTC_3118 9124250 49.47 µM 0.313951160370539 0.377650598482086 no 1236 0.376779066478105 427 1504786
SGTC_76 0433-0009 400.328 µM 0.312504972516898 0.378259359877864 no 1237 0.377328392319951 440 2841569
SGTC_915 methyl methanesulfonate (MMS) 110 mM 0.311658966147536 0.378615619863392 no 1238 0.377649857987766 443 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_2942 9052777 62.25 µM 0.311083754529374 0.378857904980646 no 1239 0.377868475437389 424 6469503
SGTC_1043 0916-0009 19.3 µM 0.310761563161973 0.378993636145504 no 1240 0.377990945999366 424 3101130
SGTC_2202 7226349 200 µM 0.30934161599447 0.379592001963723 no 1241 0.378530838658642 385 844334
SGTC_1967 st070177 51.4 µM 0.309089685428275 0.379698195691121 no 1242 0.378626652563936 437 5729214
SGTC_2097 5376186 200 µM 0.3088605745345 0.379794778352895 no 1243 0.378713794199333 386 742755
SGTC_1067 clotrimazole 1.36 µM 0.307764639296965 0.380256878096867 no 1244 0.379130715078521 384 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_1303 1160-0052 261 µM 0.307362764702871 0.380426370899296 no 1245 0.379283633384397 418 3562476
SGTC_627 1391-0720 175 µM 0.306611257906097 0.380743384576819 no 1246 0.379569641785924 448 997839
SGTC_1230 0170-0365 3.77 µM 0.30642379963471 0.380822473975621 no 1247 0.379640994917677 405 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1597 7-benzyloxygramine 47.5 µM 0.305977214155067 0.381010910244362 no 1248 0.379810997378065 411 260807
SGTC_2835 9006588 71.43 µM 0.305863635541981 0.381058839122735 no 1249 0.379854237250241 347 2345538
SGTC_3104 9120930 49.47 µM 0.304299424507213 0.381719103646204 no 1250 0.380449891778882 425 17014836
SGTC_2228 7354201 200 µM 0.302574654603381 0.382447540261651 no 1251 0.381107016127091 433 753451
SGTC_564 3555-0129 330 µM 0.302228147029249 0.382593934010975 no 1252 0.381239074340494 421 563260
SGTC_1772 st048439 82.2 µM 0.302065105034709 0.382662822377274 no 1253 0.381301216395675 392 2927068 YDL195W SEC31
SGTC_3270 9137563 49.47 µM 0.302026618431433 0.382679084246206 no 1254 0.381315885680342 429 17015724
SGTC_403 arphamenine a 50 µM 0.301741216670648 0.38279968242767 no 1255 0.381424672739788 446 5487158 An arginine aminopeptidase inhibitor.
SGTC_2107 5363541 170.161 µM 0.300410802071833 0.383362006668371 no 1256 0.38193191256465 433 244052
SGTC_685 1278-0033 54.9 µM 0.299882219121696 0.383585490288806 no 1257 0.382133498796443 439 3590572
SGTC_2344 7990960 76.95 µM 0.299710267697624 0.383658199297175 no 1258 0.382199082981841 416 140813
SGTC_2275 7947463 200 µM 0.299554144739028 0.383724218847275 no 1259 0.38225863294215 414 1225414
SGTC_763 3453-1109 128 µM 0.299522621241157 0.383737549565052 no 1260 0.382270657283934 432 1560353
SGTC_1590 st077108 57.8 µM 0.298534951853893 0.384155286721576 no 1261 0.38264745193076 415 5489485
SGTC_1018 4259-0013 28.1 µM 0.29765579569889 0.384527241200249 no 1262 0.382982942398588 409 6801262
SGTC_926 2268-1401 59.4 µM 0.296872494369009 0.384858730888903 no 1263 0.383281928150472 450 2931578
SGTC_1624 st003710 6.25 µM 0.296099883675707 0.385185778818123 no 1264 0.383576901409472 436 24207033
SGTC_3056 9094900 49.47 µM 0.296067819708709 0.385199353337841 no 1265 0.383589144497307 389 25236784
SGTC_1327 1436-0082 2.18 µM 0.296043990503054 0.385209441701008 no 1266 0.38359824335497 416 15992205
SGTC_773 4358-1457 44.6 µM 0.295785159206188 0.385319025855323 no 1267 0.383697078694906 432 1186886
SGTC_146 3448-8650 53.125 µM 0.295575923648189 0.385407618829029 no 1268 0.383776981316479 452 2891488 YIL048W NEO1
SGTC_114 0364-0001 490.298 µM 0.294491846270139 0.385866726518882 no 1269 0.384191046532015 375 4003655
SGTC_2348 9022543 33.42 µM 0.294102198972757 0.386031781581719 no 1270 0.384339905309816 446 3162678 YDL140C RPO21
SGTC_90 0870-0863 4.608 µM 0.294094886797485 0.386034879225251 no 1271 0.384342698977444 433 1738164
SGTC_1921 5740136 50 µM 0.293850258213428 0.386138514974456 no 1272 0.384436164498046 441 1774243
SGTC_1863 st057641 20.1 µM 0.293350770471473 0.386350145831507 no 1273 0.384627025205842 435 3921635
SGTC_845 0330-0138 4.51 µM 0.291773068167457 0.38701883347189 no 1274 0.385230069085662 445 9039800
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.291345339763223 0.387200178217389 no 1275 0.385393607268904 424 4620898
SGTC_2930 9013230 14.89 µM 0.291131973523735 0.387290648674731 no 1276 0.385475193589723 414 2995857
SGTC_953 1188-0045 9.7 µM 0.290773415635468 0.387442696335518 no 1277 0.385612309255751 418 6144426
SGTC_1874 staurosporine 7.6 µM 0.29032594769137 0.387632470817529 no 1278 0.385783444954587 439 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_1284 0929-0043 16 µM 0.288536640304071 0.388391597291642 no 1279 0.386467993797017 425 1239883
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.288341699020329 0.388474328345213 no 1280 0.386542595347597 447 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3267 9137951 49.47 µM 0.287634748558943 0.388774393188549 no 1281 0.386813171459575 419 16643986
SGTC_1969 st069479 40.1 µM 0.285747242746883 0.389575868995048 no 1282 0.387535859050289 448 3895485
SGTC_2723 salbutamol 83.58 µM 0.285250656715858 0.389786808377825 no 1283 0.387726056620604 425 9884233 β2-adrenoceptor agonist
SGTC_61 0978-8327 98.565 µM 0.284550008496574 0.390084484327026 no 1284 0.387994457929658 421 6150059 YHR072W ERG7
SGTC_2810 7959871 45.46 µM 0.283625149501665 0.39047751668834 no 1285 0.388348830864095 399 2974535
SGTC_2695 st077686 51.995 µM 0.282968851255388 0.390756488160146 no 1286 0.388600357321998 386 2876092
SGTC_547 1120-0019 610 nM 0.282906053549209 0.390783184414141 no 1287 0.388624427008148 411 3676939
SGTC_3134 9127454 49.47 µM 0.282783361743633 0.390835344040239 no 1288 0.388671454692975 430 24262820
SGTC_3197 9113331 49.47 µM 0.282547397386965 0.390935664431239 no 1289 0.388761904254924 376 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2383 9036125 200 µM 0.28241992839872 0.390989860969779 no 1290 0.388810768017093 435 79580
SGTC_3333 9141820 12.094 µM 0.282309699564553 0.39103672914482 no 1291 0.388853024383972 443 1939433
SGTC_2773 thioridazine 9.09 µM 0.281600542385592 0.391338293351511 no 1292 0.389124912133458 431 5452 An antipsychotic.
SGTC_342 k048-0088 23.3 µM 0.280971026526557 0.391606045377231 no 1293 0.389366311250633 393 6820570
SGTC_2168 5727979 200 µM 0.279716841197605 0.392139641087488 no 1294 0.389847378247141 400 695210
SGTC_1041 0206-0046 107 µM 0.2788517104737 0.392507831035198 no 1295 0.390179314256051 419 50494
SGTC_383 2324-0395 7.37 µM 0.276766360525401 0.393395727573478 no 1296 0.390979756460521 430 3146421
SGTC_217 ketoconazole 989 nM 0.274930065118076 0.394178041598518 no 1297 0.391684984121602 411 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_382 3229-0966 23.2 µM 0.274801852318289 0.394232679883207 no 1298 0.391734237462478 436 5722370
SGTC_1829 berberine 14.4 µM 0.274774693833901 0.394244253823249 no 1299 0.391744670700434 427 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3060 1327-0027 12.5 µM 0.274733544861136 0.394261790169127 no 1300 0.391760478690575 417 16000455 YPR107C YTH1
SGTC_2257 7960413 200 µM 0.274688625710275 0.394280933486251 no 1301 0.391777735254748 428 2974689 YIL048W NEO1
SGTC_2731 amoxapine 43.43 µM 0.274168184427602 0.394502749976686 no 1302 0.391977688397694 446 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1352 1496-0991 99 µM 0.273908657189551 0.394613375475937 no 1303 0.392077409229182 458 3000039
SGTC_2928 9011484 9.79 µM 0.273765351589776 0.394674464242707 no 1304 0.392132476058431 430 2994751
SGTC_123 0083-0120 66.675 µM 0.272802846654713 0.395084830951903 no 1305 0.392502385611706 414 16001701
SGTC_3211 9128781 49.47 µM 0.272548897483742 0.395193122326422 no 1306 0.392599999475598 426 17194361
SGTC_2106 5357045 167.29 µM 0.271239925403179 0.395751434637605 no 1307 0.393103253746965 420 668842
SGTC_1663 st014140 55.4 µM 0.270976493420151 0.395863821467585 no 1308 0.393204555816342 424 4207120
SGTC_989 1501-0895 10.3 µM 0.270907888432377 0.395893091533557 no 1309 0.393230938869319 449 2830112
SGTC_1055 3448-0672 86 µM 0.270669470155229 0.395994816379505 no 1310 0.393322629922501 416 748378
SGTC_1034 k072-0165 12.7 µM 0.269530635368781 0.39648081546617 no 1311 0.393760685284202 434 5835461
SGTC_1870 st057514 26.5 µM 0.269453913536856 0.396513562391066 no 1312 0.393790201350398 415 5393161
SGTC_877 0771-0151 33.1 µM 0.268676427334183 0.396845455391251 no 1313 0.394089346620504 432 6166523
SGTC_1484 3473-2379 286 µM 0.2684372409174 0.396947574237052 no 1314 0.394181388465674 455 671917
SGTC_2624 nerol 100 µM 0.267526543392923 0.397336454330294 no 1315 0.394531890006928 427 637566 A natural product oil.
SGTC_1010 4112-3296 15.2 µM 0.267038317438388 0.397544975434345 no 1316 0.39471982945553 415 704384
SGTC_1185 1319-0113 81.3 µM 0.26678085795668 0.397654948068138 no 1317 0.394818946701821 430 4672763
SGTC_275 trichlorophene 5.69 µM 0.266298066631439 0.397861192084399 no 1318 0.395004830983157 429 62616
SGTC_195 4234-0266 16.654 µM 0.265605418706698 0.398157134755684 no 1319 0.395271555968064 426 2303354
SGTC_277 nystatin 15.5 µM 0.264968163502902 0.398429461939155 no 1320 0.395516993661273 441 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1512 0259-0544 12.2 µM 0.264219755499188 0.398749352764694 no 1321 0.395805294568705 420 18476
SGTC_1885 st057546 99.9 µM 0.263718819242348 0.39896350516112 no 1322 0.395998296544448 402 702008
SGTC_2752 diclazuril 33.15 µM 0.261299661873 0.39999813234044 no 1323 0.396930713650354 422 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_612 0302-0167 22.4 µM 0.260908105858559 0.400165659564985 no 1324 0.397081686863309 431 235821
SGTC_198 3454-2873 16.191 µM 0.260689780237572 0.400259078153083 no 1325 0.397165873907776 436 710957
SGTC_2540 epiandrosterone 100 µM 0.260142800757738 0.400493148342541 no 1326 0.39737681194348 420 441302 A steroid.
SGTC_314 1671-0008 2.74 µM 0.25999846472618 0.400554920356495 no 1327 0.397432478927937 434 3913060
SGTC_955 1216-0110 33 µM 0.25886141282097 0.401041635434231 no 1328 0.397871085848104 424 3619719
SGTC_148 3253-0744 288.01 µM 0.258351592481296 0.401259913963942 no 1329 0.398067786134931 407 6893655
SGTC_376 3970-0862 59.1 µM 0.257685153164173 0.401545295054411 no 1330 0.398324952651008 438 3135186
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.256248314477938 0.402160753258169 no 1331 0.398879552054584 430 66535 A nucleotide analog.
SGTC_397 arbidol 50 µM 0.255727012125539 0.402384108965178 no 1332 0.399080817934311 411 131410 A RNA synthesis inhibitor.
SGTC_700 3453-2283 142 µM 0.255418787423685 0.402516185033156 no 1333 0.39919983082091 410 565664
SGTC_1334 1486-0610 236 µM 0.255230068965568 0.402597057477794 no 1334 0.399272704130505 413 3742339
SGTC_638 3970-0837 4.09 µM 0.252982971465341 0.403560336556292 no 1335 0.400140686038146 414 4118451 YLR208W SEC13
SGTC_2882 9058044 58.44 µM 0.250070916387585 0.404809537709333 no 1336 0.401266253454136 411 18076804
SGTC_2716 st080858 38.6235 µM 0.249396958710194 0.405098788039403 no 1337 0.401526868720617 434 5296050
SGTC_2847 9005661 71.43 µM 0.248956898234056 0.40528768195217 no 1338 0.401697061033789 443 2991449
SGTC_3355 9151058 44.0485 µM 0.24868504732802 0.405404383717308 no 1339 0.401802208026537 420 17015728
SGTC_3212 9128307 49.47 µM 0.248618172973753 0.405433093225028 no 1340 0.401828074901841 392 27243542
SGTC_1395 3486-0190 4.35 µM 0.248390939558543 0.405530649511498 no 1341 0.40191597157514 442 6748079
SGTC_1800 st050079 29.0735 µM 0.247561345011613 0.405886862416265 no 1342 0.402236911013593 442 3645560
SGTC_781 4335-2806 94.4 µM 0.246149148881851 0.406493413015447 no 1343 0.402783388954663 448 845254
SGTC_409 arachidonic acid 100 µM 0.245630203923145 0.406716360884425 no 1344 0.402984253025486 420 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_1462 k081-0014 26.5 µM 0.244121146819961 0.407364849885396 no 1345 0.403568497566149 434 3270634
SGTC_2761 levamisole 97.89 µM 0.243056517855845 0.407822507127401 no 1346 0.403980807482075 441 26879 An alkaline phosphatase inhibitor.
SGTC_1747 st037496 66.6 µM 0.242639440981817 0.408001832328344 no 1347 0.404142362288605 406 723305
SGTC_931 2812-0076 566 µM 0.242632888476804 0.408004649778858 no 1348 0.40414490053319 423 3450959
SGTC_68 0986-0284 82.829 µM 0.239749911228021 0.409244733753374 no 1349 0.405262069773717 400 423278 YIL048W NEO1
SGTC_1689 st020265 53.493 µM 0.239575493279331 0.409319787175315 no 1350 0.405329682537809 452 5758320 YPR016C TIF6
SGTC_1817 st052116 64.4 µM 0.239170132863954 0.40949422980118 no 1351 0.405486830590914 415 4361398
SGTC_43 0570-0105 72.5 µM 0.238776666459445 0.409663571103565 no 1352 0.405639382207159 460 1114046 YDL195W SEC31
SGTC_885 0865-0106 16.8 µM 0.237543406391709 0.410194454491339 no 1353 0.406117624603468 420 2793380
SGTC_100 0086-0128 49.5915 µM 0.237492134279103 0.410216529248875 no 1354 0.406137510308063 445 93297
SGTC_2309 7664088 163.95 µM 0.236399413337796 0.410687058181704 no 1355 0.406561375690727 456 704922
SGTC_1330 1469-0054 61.8 µM 0.234450246741542 0.411526693981546 no 1356 0.40731772707759 460 7102664
SGTC_2508 celastrol 40.54 µM 0.23381532989039 0.41180028264084 no 1357 0.407564173943687 401 122724 Celastrol is a natural product and antioxidant.
SGTC_3004 9076122 71.4286 µM 0.233674738599975 0.411860869893256 no 1358 0.407618750265765 457 44782551
SGTC_720 r052-1644 49.9 µM 0.232776919503129 0.412247830926594 no 1359 0.407967318110681 441 1422863 YOR257W CDC31
SGTC_375 3970-0961 9.27 µM 0.232391200471136 0.412414102485361 no 1360 0.408117091437481 410 2898222
SGTC_41 0478-0632 82.643 µM 0.232064570585033 0.412554914832419 no 1361 0.40824393115851 465 3750424
SGTC_1636 st007707 68.9 µM 0.229447596975439 0.413683514672838 no 1362 0.409260522847614 478 403051
SGTC_1679 SEC14.276 6.7 µM 0.2278814887485 0.414359258613168 no 1363 0.409869186985563 459 1005053 YMR079W SEC14
SGTC_585 0kpi-0023 191 µM 0.227719296082084 0.414429255983903 no 1364 0.409932235208927 448 64601
SGTC_802 4112-3352 742 µM 0.227064374410456 0.414711927672737 no 1365 0.41018684281739 403 704594
SGTC_2790 5423970 71.43 µM 0.226846317627489 0.414806053284362 no 1366 0.410271623066274 425 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1899 st063254 59.6 µM 0.226499076187375 0.414955952377623 no 1367 0.410406638829614 448 3093813
SGTC_260 nsc-65238 3.989 µM 0.226129045137753 0.415115703042412 no 1368 0.41055052742462 430 3246252
SGTC_2978 9011784 42.97 µM 0.224158633275286 0.415966609572506 no 1369 0.411316935149606 430 2994934
SGTC_2452 5863136 48.41 µM 0.223684996186323 0.416171204843824 no 1370 0.411501210730927 446 2184096
SGTC_473 2-arachidonoylglycerol 10 µM 0.22304416731807 0.416448057486174 no 1371 0.411750565841514 462 5282280 An endocannabinoid.
SGTC_103 0844-0104 51.839 µM 0.222394884018247 0.41672860491369 no 1372 0.412003247036547 423 5375804
SGTC_2334 9017922 200 µM 0.221542899250893 0.417096801509703 no 1373 0.412334868779717 444 3163164
SGTC_56 0957-0365 83.25 µM 0.220052756383301 0.417740961294599 no 1374 0.412915033937053 454 6752360
SGTC_2078 5212016 200 µM 0.21997109937788 0.417776266426369 no 1375 0.412946831398447 478 1899708
SGTC_752 1896-0090 130 µM 0.219241305373842 0.418091828744258 no 1376 0.413231040520283 441 772567
SGTC_370 0180-0345 38.7 µM 0.218130548479431 0.418572220249678 no 1377 0.413663698097028 412 3989527
SGTC_1482 3346-2049 8.48 µM 0.217326615487711 0.418919989229875 no 1378 0.413976908286027 447 3826804
SGTC_2231 micatex 6.853 µM 0.216943145576488 0.419085894721683 no 1379 0.414126326449609 447 20737 An antifungal of unknown mechanism.
SGTC_1614 st002383 48.6 µM 0.214235481098258 0.420257754081287 no 1380 0.415181714211977 452 1947235
SGTC_278 4092-0821 23.9 µM 0.214049221792841 0.420338391998397 no 1381 0.415254336568103 449 877900
SGTC_162 k030-0015 37.8 µM 0.212090981304842 0.421186381897255 no 1382 0.416018027768135 447 1809920 YMR134W ERG29
SGTC_1498 4478-3555 97.6 µM 0.211962021792515 0.421242238970713 no 1383 0.416068331654841 470 3437919
SGTC_1991 st073000 8.92 µM 0.211879800330077 0.421277852915802 no 1384 0.416100404912829 452 4301969 YIL048W NEO1
SGTC_2825 7998094 58.44 µM 0.21120211836391 0.421571413045793 no 1385 0.416364778911224 466 2987815
SGTC_2555 cholic acid 100 µM 0.211097848061927 0.421616585014647 no 1386 0.416405459697268 435 6708657 Influences liver metabolism.
SGTC_1126 isoteolin 1.0172 µM 0.211087449886247 0.421621089767752 no 1387 0.416409516567465 419 133323
SGTC_680 0417-1641 114 µM 0.209479950100649 0.422317622407232 no 1388 0.417036792839839 439 2835990
SGTC_1170 0310-0127 64.8 µM 0.208071219444649 0.42292822789244 no 1389 0.417586679453092 464 774975
SGTC_10 0279-0212 42.575 µM 0.207808668862056 0.423042049317761 no 1390 0.417689181801839 442 39851 YBR002C RER2
SGTC_1159 4092-0538 61.2 µM 0.207237045506177 0.423289882762714 no 1391 0.417912368557741 435 717301
SGTC_1764 st044502 93.5 µM 0.206452457853462 0.423630098572496 no 1392 0.418218748925893 425 8407
SGTC_846 0335-0850 148 µM 0.205985653188397 0.423832543176486 no 1393 0.418401059047664 447 6819598
SGTC_31 0508-1974 57.237 µM 0.205098119114389 0.424217505798601 no 1394 0.418747732963994 448 6810525
SGTC_3241 9133421 49.47 µM 0.205018376186285 0.424252097364988 no 1395 0.418778883924698 471 17018221
SGTC_811 0416-0114 265 µM 0.204590347503484 0.424437781257376 no 1396 0.418946098731707 465 6612453
SGTC_213 1246-0773 967 nM 0.204470005404644 0.424489990101971 no 1397 0.418993114530052 462 6251622
SGTC_2493 resveratrol 26.09 µM 0.203698191411671 0.424824862959917 no 1398 0.419294677805404 463 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2073 5212005 126 µM 0.203364569564587 0.4249696308402 no 1399 0.41942504526927 477 691789
SGTC_315 k915-0449 187 µM 0.202998896793462 0.425128318139218 no 1400 0.419567947246118 461 20970215 YNL149C PGA2
SGTC_1770 st043884 66.3 µM 0.20260449118487 0.425299487934424 no 1401 0.419722089675366 479 670149
SGTC_173 1273-0061 2.693 µM 0.202279238517609 0.425440656341774 no 1402 0.419849214875192 446 2847414 YPL266W DIM1
SGTC_1357 1503-1303 39.5 µM 0.201649063332166 0.42571419651112 no 1403 0.420095543013995 431 292895
SGTC_2062 5245942 200 µM 0.20124870412828 0.425887999029328 no 1404 0.420252055030195 444 1376160
SGTC_58 0957-0393 9 µM 0.200521617951717 0.42620367589856 no 1405 0.420536326320407 444 6997992
SGTC_1605 st000082 49.1 µM 0.200030981222122 0.426416720941316 no 1406 0.420728175617871 461 1114022
SGTC_2080 5212524 12.4 µM 0.19895290455526 0.42688492041125 no 1407 0.421149792386884 451 260183
SGTC_820 1582-0060 59.9 µM 0.198586601816193 0.427044026039467 no 1408 0.421293067536036 442 3848840
SGTC_219 mitoxanthrone 164.414 µM 0.198400643619181 0.427124802558608 no 1409 0.421365806959059 445 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.198308138262983 0.427164986172321 no 1410 0.421401992361208 469 364106
SGTC_734 2023-0417 80 µM 0.19692534761471 0.427765749630588 no 1411 0.421942978764954 469 3935732
SGTC_1200 1643-0193 18.4 µM 0.196911856100802 0.427771611944336 no 1412 0.42194825775018 468 5403974
SGTC_825 1988-2224 89.6 µM 0.196632490196896 0.427893005207597 no 1413 0.422057571722951 447 1180859
SGTC_717 1532-0246 73.2 µM 0.196217457316719 0.428073362633621 no 1414 0.422219982343194 428 9561992
SGTC_2086 5274770 176.623 µM 0.196091208624239 0.428128228472334 no 1415 0.422269388592309 446 689278
SGTC_2360 9040895 200 µM 0.196019435805601 0.428159420511101 no 1416 0.422297476761312 425 4914414
SGTC_2977 9011197 71.43 µM 0.195664908779615 0.428313502422561 no 1417 0.422436226096824 501 2704722
SGTC_476 mead acid 10 µM 0.195319330936446 0.428463705425689 no 1418 0.422571482302709 455 5312531 An omega 9 fatty acid.
SGTC_290 2043-6722 48.1 µM 0.194515250345922 0.428813233528132 no 1419 0.422886227862873 460 773758 YLR208W SEC13
SGTC_2496 diffractaic acid 79.83 µM 0.194047746637541 0.429016479745772 no 1420 0.423069247982253 432 94870 An apoptosis inducer which activates caspases.
SGTC_1102 cgs 12066b 26.1 µM 0.19393584310817 0.429065132355061 no 1421 0.423113058863344 446 6438352 A 5-HT1B full agonist.
SGTC_1827 berberine 7.24 µM 0.193467960571624 0.429268566614281 no 1422 0.423296247883859 464 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2693 st077581 40.7 µM 0.192554023471073 0.429665998523898 no 1423 0.423654127464566 474 25238761
SGTC_1694 st024011 44.9 µM 0.191484888078517 0.43013100994139 no 1424 0.424072859525097 460 2787533
SGTC_1776 st049249 45.9 µM 0.190320605955522 0.430637514856189 no 1425 0.424528953765446 442 1822314
SGTC_785 1270-0111 65.3 µM 0.190277961130276 0.430656069072257 no 1426 0.424545661311785 439 6741994
SGTC_1795 st049545 62.3 µM 0.188725035825491 0.431331830899023 no 1427 0.425154164216256 445 5291882
SGTC_1555 citronellol 128 µM 0.18853113796152 0.43141622050985 no 1428 0.425230154290807 486 8842 A terpine precursor.
SGTC_2680 butyl paraben 22.24 µM 0.188117445963444 0.431596280951197 no 1429 0.425392292671334 472 7184 An antifungal and steroid mimetic.
SGTC_1443 4112-3303 14 µM 0.18772043442329 0.431769094549479 no 1430 0.425547905342877 473 704433
SGTC_661 1304-0007 33.6 µM 0.187130300830905 0.432025995611728 no 1431 0.425779235573075 459 3117130
SGTC_2814 7977482 42.97 µM 0.185384581106497 0.432786122360674 no 1432 0.42646370065177 473 6456762
SGTC_1583 clindamycin 39.6 µM 0.184696860103451 0.433085640458974 no 1433 0.426733404540963 463 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_2139 5578692 56.4705 µM 0.184226884420326 0.433290347653359 no 1434 0.426917734852955 458 650991 YMR113W FOL3
SGTC_2020 4017018 200 µM 0.184152835453341 0.433322602777632 no 1435 0.42694677923585 461 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_830 4076-0286 57.8 µM 0.184139300004615 0.433328498756391 no 1436 0.426952088316344 447 6866659
SGTC_2646 retinol 96.75 µM 0.183466634929394 0.43362152721302 no 1437 0.427215947939042 463 445354 A vitamin A analog and teratogen.
SGTC_647 0140-0236 81 µM 0.183442939059862 0.433631850347832 no 1438 0.427225243476008 462 990837
SGTC_2093 5331342 194.4 µM 0.183036502655089 0.433808921911526 no 1439 0.427384688714897 474 33839
SGTC_2235 salicylic acid 500 µM 0.182848037053001 0.433891034959639 no 1440 0.42745862790768 450 338 A COX inhibitor and kinase inhibitor.
SGTC_1389 3405-0187 19 µM 0.182617771068861 0.43399136399241 no 1441 0.427548969766069 482 799890
SGTC_664 1222-0054 14.9 µM 0.181696631302796 0.434392755631337 no 1442 0.4279104048998 448 6813991
SGTC_1881 5652484 16 µM 0.18077748379931 0.434793346557667 no 1443 0.428271118615008 469 2255129
SGTC_2954 9074818 52.69 µM 0.178496512048012 0.435787748032969 no 1444 0.429166530097284 473 16648742
SGTC_3231 9132313 49.47 µM 0.178147989616188 0.435939724118012 no 1445 0.429303377252031 466 4905967
SGTC_2491 paeonol 100 µM 0.178121624605104 0.435951221184003 no 1446 0.42931372980606 459 11092 Increases levels of cortical cytochrome oxidase.
SGTC_908 3448-7491 47.7 µM 0.176380863871076 0.436710439011332 no 1447 0.429997368698262 453 1203031
SGTC_604 1000-0114 314 µM 0.175704917872473 0.437005310054784 no 1448 0.430262885756409 467 1572745
SGTC_3299 9121982 43.1275 µM 0.173961653739017 0.43776594335629 no 1449 0.43094779927409 450 17594604 YPL160W CDC60
SGTC_1158 4092-0494 91.8 µM 0.173117754075018 0.438134242412509 no 1450 0.431279434958275 468 1148199
SGTC_1253 0550-0034 176 µM 0.172543863498302 0.438384733340852 no 1451 0.43150499016643 442 5969915
SGTC_2638 epoxomicin 18 µM 0.172062625600792 0.438594802395627 no 1452 0.431694147475245 468 9915668 A protesome inhibitor.
SGTC_1987 st072290 61.9 µM 0.171414320821901 0.438877826510075 no 1453 0.431948997522391 476 54697379
SGTC_1262 0737-0114 49.6 µM 0.170153567733018 0.439428310591944 no 1454 0.432444683360766 486 765919
SGTC_1209 2323-2347 50.3 µM 0.170085496939076 0.439458035764418 no 1455 0.432471449547182 467 5412760
SGTC_74 000s-0487 160.283 µM 0.169490637696084 0.439717813565077 no 1456 0.432705367931542 402 677548
SGTC_1105 epirubicin 18.1 µM 0.167770140714837 0.440469308328024 no 1457 0.433382056881325 458 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_299 1273-0059 1.44 µM 0.165233273700198 0.441577775342073 no 1458 0.43438018828704 471 2848077
SGTC_1146 3579-1023 7 µM 0.163585785799443 0.442297879823857 no 1459 0.435028617622946 458 X1146
SGTC_1071 trifluoperazine 6.31 µM 0.163164887727723 0.442481881861185 no 1460 0.4351943056067 480 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1104 tacrolimus 29.8 µM 0.162935038466098 0.442582369226406 no 1461 0.435284791370228 461 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2929 9013348 24.6 µM 0.162798849767996 0.442641911049719 no 1462 0.435338406969418 462 2995952
SGTC_1813 st051246 8.6015 µM 0.161952563130876 0.44301193732835 no 1463 0.435671604873333 476 5291959
SGTC_2322 7413319 38.22 µM 0.161164290592083 0.443356642523828 no 1464 0.435982002694985 470 1840400
SGTC_2801 7907800 81.82 µM 0.160888659056103 0.443477184090634 no 1465 0.436090547350529 490 6620925
SGTC_1476 4112-3294 3.34 µM 0.160053022767517 0.44384266369927 no 1466 0.436419653206595 487 704369
SGTC_2077 5212015 200 µM 0.159777782032061 0.443963055345066 no 1467 0.436528063290772 475 780900
SGTC_1660 st012960 28.1 µM 0.159771880563703 0.4439656367329 no 1468 0.436530387776129 489 24207266
SGTC_941 3237-0776 460 µM 0.159755944249383 0.443972607519744 no 1469 0.436536664823069 489 760008
SGTC_354 2783-3500 4.88 µM 0.159299430469478 0.444172300958941 no 1470 0.436716484724497 457 6740761
SGTC_320 4092-0846 5.34 µM 0.158283063769918 0.444616942449847 no 1471 0.437116876530436 469 1359356
SGTC_177 1327-0068 8.361 µM 0.156458030078663 0.445415535269311 no 1472 0.43783599945832 460 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_2121 5257820 149.641 µM 0.156388589399949 0.445445925310685 no 1473 0.437863365425977 499 791256
SGTC_1128 3448-9350 235 µM 0.156054564840451 0.44559211240485 no 1474 0.437995005751038 413 619386
SGTC_1226 3909-7979 35.4 µM 0.155419504220243 0.44587006944017 no 1475 0.438245304424259 491 6615510
SGTC_699 0375-0592 111 µM 0.155181738027112 0.445974143186563 no 1476 0.438339022411026 482 762578
SGTC_2893 9048488 25.97 µM 0.155126800508192 0.44599819067318 no 1477 0.438360677090279 458 6467338
SGTC_2717 st081029 62.2815 µM 0.154484195473586 0.446279489235112 no 1478 0.438613985906104 495 5292846
SGTC_2768 sulfasalazine 50.2 µM 0.153390714540264 0.446758219539224 no 1479 0.439045083479002 462 5384001 An antioxidant and salicylic acid derivative.
SGTC_1712 st032288 53.4 µM 0.152141219487994 0.447305348404701 no 1480 0.439537777075852 478 2883011
SGTC_2040 5100729 123 µM 0.15185134269945 0.447432294017209 no 1481 0.439652093013063 488 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_512 prima-1 270 µM 0.150279791508259 0.448120616138623 no 1482 0.440271937980279 456 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_2290 7904846 200 µM 0.150196427228855 0.448157133156993 no 1483 0.440304822289968 455 2962154
SGTC_381 3461-2219 42.7 µM 0.149946252520783 0.448266722710704 no 1484 0.440403509984855 479 2883159
SGTC_1530 rhein 70.4 µM 0.149857044884047 0.448305801257773 no 1485 0.440438701072684 484 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_1184 1269-1718 139 µM 0.14811225936097 0.449070227276769 no 1486 0.441127087292992 463 5403821
SGTC_2339 9000433 200 µM 0.147943808235519 0.449144039194398 no 1487 0.441193557309559 459 2988954
SGTC_1068 loratadine 26.9 µM 0.147437435271203 0.449365932297546 no 1488 0.441393379650777 479 3957 A H1 histamine antagonist.
SGTC_2818 7996756 12.99 µM 0.147306040997176 0.449423511980796 no 1489 0.441445232235318 492 2241621
SGTC_3114 9122766 49.47 µM 0.146402225888385 0.449819611213963 no 1490 0.441801935119846 454 17176985
SGTC_868 0527-0199 213 µM 0.146371267022744 0.449833179902223 no 1491 0.441814154293579 487 2849450
SGTC_2931 9014674 55.67 µM 0.146290909193295 0.449868399500436 no 1492 0.4418458710331 472 2996810
SGTC_2902 5787006 60.46 µM 0.145380832413298 0.450267299621415 no 1493 0.442205098698154 456 591003
SGTC_1056 3448-1962 115 µM 0.143331982894624 0.451165523978914 no 1494 0.443013998951733 473 715507
SGTC_11 0438-0307 1.3 µM 0.141809741693405 0.451833043212847 no 1495 0.443615144540363 484 4011476
SGTC_3321 9137793 26.8275 µM 0.141578385947471 0.451934507179799 no 1496 0.443706520225154 473 4904192
SGTC_3255 9139072 49.47 µM 0.140342212226632 0.452476699728183 no 1497 0.444194806899308 473 17646060
SGTC_3356 9151811 4.48 µM 0.140238656545527 0.452522123853032 no 1498 0.444235715086265 504 1859254 YPR165W RHO1
SGTC_73 0327-0325 16.231 µM 0.139161595289731 0.452994607528291 no 1499 0.444661227834715 481 53298
SGTC_2849 9019321 12.99 µM 0.139004247194561 0.453063638351074 no 1500 0.444723396428804 491 16489627
SGTC_2 0422-0095 29 µM 0.138630999520349 0.453227393025547 no 1501 0.444870872878513 446 6790840
SGTC_2610 ononetin 44.17 µM 0.137662133340425 0.453652500015331 no 1502 0.445253723806965 471 259632
SGTC_1628 st004252 77.7 µM 0.136875072612628 0.453997875800534 no 1503 0.445564771270339 464 692968
SGTC_471 1-acyl-paf 4 µM 0.13606806444272 0.454352040987672 no 1504 0.445883736783484 471 16759367
SGTC_1722 st034304 3.6505 µM 0.135677477141022 0.454523467948529 no 1505 0.446038126844493 479 4036148 YLR033W RSC58
SGTC_3076 9116187 49.47 µM 0.135213687624546 0.454727034021355 no 1506 0.446221462659547 488 27241210
SGTC_2049 5262831 67.185 µM 0.134301051602456 0.45512764206415 no 1507 0.446582260859106 482 763417
SGTC_1236 0330-0013 258 µM 0.134113580370107 0.455209939552296 no 1508 0.446656380538039 482 4617066
SGTC_2903 5923464 63.88 µM 0.13343216120124 0.455509090071905 no 1509 0.446925805924733 487 2876576
SGTC_1515 3460-0031 42.1 µM 0.130726173244536 0.456697295951349 no 1510 0.447995963380918 473 2876596
SGTC_897 1000-0139 31.4 µM 0.130436828824871 0.456824370894481 no 1511 0.448110415142871 492 6151020
SGTC_165 k038-0023 64.381 µM 0.129884254066137 0.457067064195887 no 1512 0.448329001093777 469 46368543
SGTC_2143 5623677 140.463 µM 0.12806063289551 0.457868119896055 no 1513 0.449050494935261 492 5375313
SGTC_1183 1254-0324 198 µM 0.127656882546216 0.458045497159657 no 1514 0.449210256785245 470 5799357
SGTC_605 1315-0399 119 µM 0.127502649709432 0.458113257571216 no 1515 0.449271288067418 469 24020461
SGTC_3287 9117173 37.0625 µM 0.127169325486619 0.458259703866032 no 1516 0.44940319147497 491 2789709
SGTC_2779 methotrexate 400 µM 0.127165319918553 0.458261463750431 no 1517 0.449404776596553 493 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_1386 3228-0095 33.8 µM 0.126660455195979 0.458483287403871 no 1518 0.449604572933636 498 870181
SGTC_3081 9117243 49.47 µM 0.125831520716299 0.458847526393559 no 1519 0.449932645076032 480 45595589
SGTC_2740 felodipine 17.08 µM 0.12559992298817 0.458949298070849 no 1520 0.450024311959988 502 3333 L-type calcium channel blocker
SGTC_1802 st050112 57.9 µM 0.124769219837275 0.459314358508649 no 1521 0.450353127972527 472 4662563
SGTC_102 gallobenzophenone 83.616 µM 0.12449773505793 0.45943367254271 no 1522 0.450460596795686 485 70837
SGTC_2682 pyrogallin 40.03 µM 0.12395261056407 0.459673258700058 no 1523 0.45067639844714 483 822798 An ATP competetive kinase inhibitor.
SGTC_1492 4158-0558 28.5 µM 0.123545056523748 0.459852391220487 no 1524 0.450837748800942 495 3967268
SGTC_2204 7233102 200 µM 0.123445825784633 0.459896007413717 no 1525 0.450877035410645 493 2172480
SGTC_530 4358-1714 28 µM 0.122886455488135 0.460141883817925 no 1526 0.45109850564213 499 1564641
SGTC_3032 9089427 49.47 µM 0.122395013173193 0.460357914429063 no 1527 0.451293093865226 497 17173707
SGTC_2457 5731572 11.68 µM 0.122195175939241 0.460445763205866 no 1528 0.451372223434399 500 2865357
SGTC_2163 5671233 125 µM 0.122009463937996 0.460527404238019 no 1529 0.451445761566107 494 701023
SGTC_1112 tnp00069 1.16933 µM 0.121722218597751 0.460653683715373 no 1530 0.451559508092074 506 145826
SGTC_2406 ethylparaben 405.7 µM 0.121616467285519 0.460700175357967 no 1531 0.45160138564604 446 8434 A possible steroid mimic.
SGTC_2837 9008476 45.46 µM 0.121415536502668 0.460788512404644 no 1532 0.451680955784747 498 2992805
SGTC_1970 st070122 35.8 µM 0.121259010493865 0.460857328713488 no 1533 0.451742942635965 507 102928
SGTC_128 0906-2981 13.371 µM 0.120918578784096 0.461007002795957 no 1534 0.451877763202927 490 6740226
SGTC_1539 benzyladenosine 56 µM 0.120741899198471 0.461084683857405 no 1535 0.451947735494818 457 92208 A nucleotide analog.
SGTC_581 0958-0271 211 µM 0.118947709614105 0.461873622322895 no 1536 0.452658391617645 474 4591145
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 0.117653023455835 0.462443013239542 no 1537 0.453171295008495 493 5355888
SGTC_3038 9091290 49.47 µM 0.117398731022044 0.462554857764178 no 1538 0.453272044808638 507 25236843
SGTC_2661 dactinomycin 12.96 µM 0.116301926172237 0.463037295299852 no 1539 0.453706629554404 496 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2816 7982706 58.44 µM 0.114711579313947 0.463736917239384 no 1540 0.45433686777708 485 2981853
SGTC_1534 6-azauridine 81.6 µM 0.114604242941622 0.46378414048797 no 1541 0.454379408245376 508 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_656 4090-1979 187 µM 0.113089230044076 0.464450733164143 no 1542 0.454979906697477 495 22330961
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.113049875104799 0.464468050337632 no 1543 0.454995507004477 502 6708784 An antioxidant flavonoid
SGTC_2569 tetrandrine 100 µM 0.111718335282181 0.465054001153362 no 1544 0.455523370444111 455 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1818 st052136 56.3 µM 0.11144017976292 0.465176414504039 no 1545 0.455633649814543 499 674169
SGTC_1477 0139-0234 16 µM 0.109355044338963 0.466094165069232 no 1546 0.456460444628313 491 620880
SGTC_959 1222-0044 107 µM 0.10927837157348 0.466127915252907 no 1547 0.456490850415616 492 6083612
SGTC_2328 6201408 200 µM 0.109161283233138 0.466179456227085 no 1548 0.456537284124333 490 2890418
SGTC_2164 5685496 200 µM 0.1088176487103 0.466330723561877 no 1549 0.456673562649283 463 759046
SGTC_2342 7990637 118.86 µM 0.10701176677536 0.467125749168164 no 1550 0.457389822412155 492 2033102 YER133W GLC7
SGTC_2719 novobiocin 32.65 µM 0.106473544519513 0.467362722884753 no 1551 0.457603322244502 474 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1893 st059353 36.1 µM 0.105511511842774 0.467786324728212 no 1552 0.457984967924248 507 3112488
SGTC_1912 st060209 90.8 µM 0.105161492755618 0.46794045406884 no 1553 0.458123832788431 509 688787
SGTC_2921 7974240 10.71 µM 0.105045281220693 0.467991628362724 no 1554 0.458169939116672 488 2979074 YDR527W RBA50
SGTC_2119 5528445 120.635 µM 0.104047283540337 0.468431123005897 no 1555 0.458565912666312 500 791935
SGTC_344 k064-0035 6.43 µM 0.104012363028556 0.4684465018756 no 1556 0.458579768754984 498 5088750
SGTC_943 3253-1379 105 µM 0.103872859437721 0.468507939232447 no 1557 0.458635122802064 504 668464
SGTC_3136 9095672 49.47 µM 0.103115981038965 0.468841281381623 no 1558 0.458935460800073 505 17217380
SGTC_3046 9092212 49.47 µM 0.101550627647849 0.469530758742865 no 1559 0.45955668509469 490 25236637
SGTC_1758 st042942 75.2445 µM 0.10133901986413 0.469623970808157 no 1560 0.459640671120298 508 669317
SGTC_1307 1187-1599 12.2 µM 0.10122623083209 0.469673654437106 no 1561 0.459685437234858 506 1538471
SGTC_687 k029-0044 34.9 µM 0.101213612857707 0.469679212690952 no 1562 0.459690445357218 503 5829338
SGTC_1 0258-0098 57.368 µM 0.100387693189562 0.470043045469936 no 1563 0.460018269910769 469 6790032 YDR047W HEM12
SGTC_1655 st012546 55.1 µM 0.0986153192734165 0.470823892760887 no 1564 0.460721853145588 508 720985 YLR208W SEC13
SGTC_1388 3346-4487 254 µM 0.0980099621237302 0.471090618257352 no 1565 0.46096219141285 506 3345614
SGTC_2967 9089538 49.85 µM 0.0978453323238333 0.471163157792042 no 1566 0.461027555035153 512 728216
SGTC_2974 9094440 9.66 µM 0.0954941451927621 0.472199246141819 no 1567 0.46196117023446 469 25236134
SGTC_860 0443-0016 25.1 µM 0.0948816173279968 0.472469197554516 no 1568 0.462204428942661 496 5337942
SGTC_913 3487-1245 167 µM 0.0944168784633281 0.472674024294051 no 1569 0.462389004311692 507 4016153
SGTC_751 0833-0568 350 µM 0.093072475127279 0.473266590555872 no 1570 0.462922992082304 513 6954252
SGTC_677 0929-0063 136 µM 0.0925462224097802 0.473498560646629 no 1571 0.463132034297181 509 1539583
SGTC_2706 st078239 82.5 µM 0.0925296513841523 0.473505865234735 no 1572 0.463138616935057 512 15434492
SGTC_180 1486-1293 102.781 µM 0.0923325625032155 0.473592743647422 no 1573 0.463216908863267 497 4140536
SGTC_727 3032-0951 202 µM 0.0921292301306554 0.473682375559288 no 1574 0.463297682460026 502 3652836
SGTC_2268 7933382 153.85 µM 0.091223533191065 0.474081636263505 no 1575 0.463657488065117 447 935025 YOR257W CDC31
SGTC_2396 5342950 42.78 µM 0.0904108259280008 0.474439926264208 no 1576 0.463980377040325 507 1886677
SGTC_222 nsc-310342 10.666 µM 0.0897799439531663 0.474718071064234 no 1577 0.46423104311198 517 432556
SGTC_2446 5162541 200 µM 0.0889947604161172 0.475064261914417 no 1578 0.46454303709036 496 1549321
SGTC_978 1416-0512 87.4 µM 0.0882160895314718 0.475407599902194 no 1579 0.464852464787576 501 6814003
SGTC_2255 7941087 197.44 µM 0.0881540710934458 0.475434946371856 no 1580 0.464877110547901 503 935561
SGTC_2411 st077133 39.94 µM 0.0848196123035738 0.476905412873344 no 1581 0.466202400681726 516 1403142 YNL221C POP1
SGTC_2316 5844804 197.44 µM 0.0847132655069256 0.47695231614127 no 1582 0.4662446747651 504 776813
SGTC_75 0159-0059 199.013 µM 0.084362272446204 0.477107120636403 no 1583 0.466384201272129 523 5377270
SGTC_970 1315-0089 19.5 µM 0.0841763082087743 0.477189141038082 no 1584 0.466458127316425 511 6811083 YLR033W RSC58
SGTC_2122 5258151 111.688 µM 0.08397884991029 0.477276232007126 no 1585 0.466536623841768 486 2173356
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM 0.0837226638079493 0.477389227081763 no 1586 0.466638468646464 509 6728940
SGTC_642 0335-0876 158 µM 0.0834447268732098 0.477511817772722 no 1587 0.466748962796758 517 6812350
SGTC_713 1488-1073 324 µM 0.0823859820635524 0.477978821728346 no 1588 0.467169891423247 526 3312542
SGTC_2820 7989630 71.43 µM 0.0811575756555298 0.478520699925625 no 1589 0.467658318947956 517 2984098
SGTC_2645 abamectin 100 µM 0.0801050596613975 0.478985020457799 no 1590 0.46807684932717 513 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1087 pterostilbene 9.05 µM 0.0798129311407722 0.479113898899048 no 1591 0.468193019786255 512 5281727 Similar to reservatol, lowers cholesterol.
SGTC_468 gf-109203x 121 µM 0.0792915001493742 0.479343944210089 no 1592 0.468400383457267 521 2396 A protein kinase C inhibitor.
SGTC_2984 9022109 38.96 µM 0.0786345258841696 0.479633798389962 no 1593 0.468661662435285 506 6459207
SGTC_3156 9099931 49.47 µM 0.0782171468899351 0.479817949785768 no 1594 0.468827661278838 500 18111053
SGTC_2126 5251174 33.877 µM 0.077537145950641 0.480117981572969 no 1595 0.469098121005435 487 790722
SGTC_2125 5246583 200 µM 0.0766020558933227 0.480530582806716 no 1596 0.46947006169746 511 835267
SGTC_2165 5727197 32.143 µM 0.0762719835068156 0.480676229690519 no 1597 0.4696013574113 516 1361712
SGTC_2213 7173844 200 µM 0.0753407531317802 0.481087155828711 no 1598 0.469971798646909 512 892728
SGTC_1856 st057054 55.7 µM 0.0751630354241953 0.481165580021366 no 1599 0.470042497292858 508 1266018
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 0.0748888708867605 0.481286566200385 no 1600 0.470151565718625 506 279621
SGTC_407 eburnamonine 100 µM 0.0745716558472001 0.481426552302958 no 1601 0.470277763334543 516 3195
SGTC_2891 9063876 19.48 µM 0.0737148305238464 0.481804678301106 no 1602 0.470618648922075 524 6472478
SGTC_2567 aureobasidin a 60 nM 0.0734600299188635 0.481917127652519 no 1603 0.470720024803511 501 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_142 0335-0849 62.6745 µM 0.0730167434326482 0.482112763570089 no 1604 0.470896396871232 512 3889043 YPR107C YTH1
SGTC_386 1509-0011 3.07 µM 0.0717273879676216 0.482681819983108 no 1605 0.471409429923733 512 3107280
SGTC_2806 7952793 58.44 µM 0.0716392819440475 0.482720706835151 no 1606 0.471444488950458 506 2972490
SGTC_1295 1013-0063 9.78 µM 0.0713802454229547 0.482835037254629 no 1607 0.471547565684412 506 6826038
SGTC_2433 5607874 27.82 µM 0.0706291091777879 0.483166572670024 no 1608 0.471846471242705 526 2252428
SGTC_1702 st027038 51 µM 0.0701981703714091 0.483356785078262 no 1609 0.472017965283462 498 5521182
SGTC_2149 5554786 194.827 µM 0.0690827577569015 0.483849135387083 no 1610 0.472461872776355 501 745063 YPR165W RHO1
SGTC_3002 9075603 71.4286 µM 0.0688292739371639 0.483961028238243 no 1611 0.472562758052511 519 20105405
SGTC_2203 7227154 166.4 µM 0.0684738642793792 0.48411791532731 no 1612 0.472704212258532 503 896304
SGTC_3268 9137683 49.47 µM 0.0672596638538787 0.484653913452953 no 1613 0.473187493860183 533 1953228
SGTC_1280 0880-0253 10.1 µM 0.0660376707394657 0.485193379588532 no 1614 0.473673916992362 515 6836607
SGTC_2460 5552655 174.22 µM 0.0659698198441131 0.485223334128754 no 1615 0.473700926685364 472 5401989
SGTC_636 0kpi-0074 126 µM 0.0657471289854586 0.48532164737787 no 1616 0.473789575026606 520 616434
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.0657377490374453 0.485325788443837 no 1617 0.473793309006473 514 1377
SGTC_2670 beta-carotene 100 µM 0.0651573675621739 0.485582018721502 no 1618 0.474024352358656 512 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_2380 9035439 200 µM 0.0638182345357079 0.486173249700675 no 1619 0.474557479397478 486 6462575
SGTC_284 0988-0104 32.6 µM 0.0636038481415568 0.4862679047499 no 1620 0.47464283378751 515 4666532
SGTC_491 tetrandrine 80.3 µM 0.0635306170338904 0.486300237642061 no 1621 0.474671989806326 508 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2304 7443016 91.4 µM 0.0614733533117632 0.487208593747286 no 1622 0.475491117618629 535 939854
SGTC_1621 st003705 32.4 µM 0.060876387154739 0.487472188459801 no 1623 0.475728827440275 499 24207032
SGTC_2094 5332512 191.667 µM 0.0607223364627202 0.487540211547037 no 1624 0.475790171289059 519 755774
SGTC_1076 itraconazole 331 nM 0.0602368886087494 0.48775456972418 no 1625 0.475983483091184 515 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_3350 9150499 3.57 µM 0.0589267929955716 0.488333083341025 no 1626 0.476505208701189 523 4910996 YPR165W RHO1
SGTC_2968 9090663 33.37 µM 0.0585933831730624 0.488480314823582 no 1627 0.47663799054637 521 25236811
SGTC_2552 juarezic acid 87.02 µM 0.0584711904614582 0.488534274678069 no 1628 0.476686654951093 510 1549512
SGTC_359 0081-0058 15.9 µM 0.0576404817085539 0.488901118137595 no 1629 0.477017501759464 529 3494159
SGTC_457 grayanotoxin iii 135 µM 0.0572405410570457 0.489077736488196 no 1630 0.477176791994981 526 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_2208 7283366 200 µM 0.0571804080029072 0.489104292116431 no 1631 0.47720074238536 525 898663
SGTC_1751 st044839 27.194 µM 0.0571085949894575 0.489136005847256 no 1632 0.477229344893896 521 5291326
SGTC_1415 3966-0071 78.1 µM 0.0569693863268482 0.489197482728374 no 1633 0.477284790846544 527 2893185
SGTC_1755 st041960 45.185 µM 0.0561494332689168 0.489559592915908 no 1634 0.477611381985062 528 2257073
SGTC_886 0866-0150 153 µM 0.0552498412076208 0.489956883413649 no 1635 0.477969711001163 525 271463
SGTC_3075 9116269 49.47 µM 0.0541766789360164 0.490430841429525 no 1636 0.478397200451896 519 17015205 YNL244C SUI1
SGTC_1332 1480-0653 17.5 µM 0.053988897203073 0.490513775922128 no 1637 0.478472005044738 536 5749438
SGTC_1393 3470-5649 58.2 µM 0.0537073255416638 0.490638133848806 no 1638 0.478584173144741 527 4108395
SGTC_66 0109-0187 42.4 µM 0.0528467644722692 0.491018211743269 no 1639 0.478927000436251 469 759417
SGTC_447 ml7 120 µM 0.0524817181169473 0.491179441657378 no 1640 0.479072431043468 516 4216 Selective myosin light chain kinase inhibitor.
SGTC_2127 5253358 187.912 µM 0.0511499277102947 0.491767665148908 no 1641 0.479603025736429 516 20612
SGTC_538 2922-0838 53.3 µM 0.0504145010258167 0.492092495225264 no 1642 0.479896040466649 496 777039
SGTC_600 1495-0418 41.6 µM 0.0491912736587441 0.492632793138909 no 1643 0.48038343273037 522 5377768
SGTC_3131 9127911 49.47 µM 0.0483535615714981 0.493002817320161 no 1644 0.480717234239877 509 45595681
SGTC_814 3342-0569 96 µM 0.0479303778989436 0.493189743268342 no 1645 0.480885864571728 528 4346283
SGTC_3039 9090270 49.47 µM 0.0477031876060475 0.493290096911103 no 1646 0.480976396827385 526 17173750
SGTC_1868 st057644 42.7 µM 0.0468780082164416 0.493654595576854 no 1647 0.481305227860869 514 688665
SGTC_2730 imipramine 71.33 µM 0.0466598353861222 0.493750967890061 no 1648 0.481392171088277 534 3696 A tricyclic antidepressant.
SGTC_1507 4075-3230 155 µM 0.0464830234025499 0.493829070366282 no 1649 0.481462632410954 518 659771
SGTC_826 1683-5028 118 µM 0.0449848436109781 0.494490864747715 no 1650 0.482059694885312 514 722377
SGTC_325 2810-4341 181 µM 0.0448920850281744 0.494531839725548 no 1651 0.482096662859222 511 774970
SGTC_1746 st038117 42 µM 0.0442919616710548 0.494796938307851 no 1652 0.482335839522753 537 2898218
SGTC_1728 st035614 33.7865 µM 0.0442363234638579 0.494821516056075 no 1653 0.48235801422176 504 15945546
SGTC_2622 2-methoxyxanthone 59.94 µM 0.043378424338239 0.495200488799072 no 1654 0.482699938196597 530 71034 A hepatoprotective.
SGTC_149 3970-0822 46.1 µM 0.0432074198195001 0.495276029737549 no 1655 0.48276809522666 502 3114250 YBL034C STU1
SGTC_2918 7977171 22.06 µM 0.0414102749773551 0.49606992496333 no 1656 0.483484410788654 529 2236483
SGTC_932 2857-0803 154 µM 0.0411575598163954 0.496181564119041 no 1657 0.483585143671764 523 674898
SGTC_889 0919-1524 82.7 µM 0.0411302866899238 0.496193612281718 no 1658 0.483596014869633 496 3905452
SGTC_1469 k284-2957 126 µM 0.0405628840342723 0.496444268565424 no 1659 0.483822187019501 525 23884841
SGTC_1510 1123-0200 71.5 µM 0.0403395419618846 0.496542932741345 no 1660 0.483911214747116 534 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_2991 9074669 71.4286 µM 0.0398180800898771 0.496773295909616 no 1661 0.484119080917195 533 17333109
SGTC_850 0388-0143 75.9 µM 0.0391829789086501 0.49705386229805 no 1662 0.484372252038988 534 67273
SGTC_539 4859-0462 2.54 µM 0.0389006047496866 0.497178606201483 no 1663 0.484484817207441 503 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_1732 st034308 51.822 µM 0.0383631178917324 0.497416051516376 no 1664 0.484699083490273 531 830119
SGTC_229 benomyl 22.8748 µM 0.0381540410367266 0.497508415551595 no 1665 0.484782432065667 505 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_856 0433-0016 11.3 µM 0.0373957705737393 0.497843398333059 no 1666 0.485084722453485 516 3911780
SGTC_2767 sibutramine 71.45 µM 0.0369280214278209 0.498050037657644 no 1667 0.485271198555893 529 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_218 alverine citrate 93.75 µM 0.0368081195478056 0.498103007255041 no 1668 0.485318999987101 531 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2724 maprotiline 69.64 µM 0.0366066279722886 0.498192021177147 no 1669 0.485399329358196 534 4011 A tricyclic antidepressant.
SGTC_2148 5546263 113.568 µM 0.0356757656120957 0.498603253909137 no 1670 0.485770447243844 527 792097
SGTC_714 4296-0578 26.1 µM 0.0356504899600376 0.498614420110498 no 1671 0.485780524359743 525 1589775
SGTC_2614 arthonioic acid 13.39 µM 0.0347742480673231 0.49900152422245 no 1672 0.486129877636812 530 6710684
SGTC_78 0336-0123 156.75 µM 0.034417054666681 0.499159324585267 no 1673 0.486272291935422 531 6765896
SGTC_1725 st036284 20.55 µM 0.0341166698105685 0.499292028257629 no 1674 0.486392057818204 498 707914
SGTC_2934 9036370 36.88 µM 0.034105688796108 0.499296879438999 no 1675 0.486396436061211 529 6462800
SGTC_1410 3909-8106 77.9 µM 0.0337327222255084 0.499461648287269 no 1676 0.486545142625548 536 1039210
SGTC_1472 k841-0093 193 µM 0.0331595417297487 0.499714867639056 no 1677 0.486773680694386 523 X1472
SGTC_1951 sophoraflavanone G 9.2 µM 0.0328403790469057 0.499855867202973 no 1678 0.486900938871579 517 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1888 azatryptophan 97.5 µM 0.032187869166578 0.499855867202973 no 1679 0.487161115085237 495 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_1411 3909-8223 150 µM 0.0320373262667572 0.499789360416854 no 1680 0.487221142054479 530 X1411
SGTC_1852 st056254 31.4 µM 0.0300007124284939 0.498889627249052 no 1681 0.488033242495912 535 442583
SGTC_1203 3992-3522 103 µM 0.028604176537576 0.498272670045907 no 1682 0.488590140526748 531 5322312
SGTC_1820 st053765 18.6 µM 0.0283639137785144 0.49816652790055 no 1683 0.488685952623496 525 3690829
SGTC_3001 9076041 71.4286 µM 0.0281868877686015 0.498088322269772 no 1684 0.488756547557583 526 16004211
SGTC_1259 0671-0132 43 µM 0.0279413255250486 0.497979839180106 no 1685 0.488854474147965 524 X1259
SGTC_1866 st057638 64 µM 0.0279360717105398 0.497977518181452 no 1686 0.488856569298839 533 688802
SGTC_185 k048-0037 25.491 µM 0.0278666589131454 0.497946853418716 no 1687 0.48888425022181 538 6827589
SGTC_384 k007-0144 5.16 µM 0.0265665210207615 0.497372488861091 no 1688 0.489402738092293 532 6824886
SGTC_2266 7929956 200 µM 0.0263540968004049 0.49727864626785 no 1689 0.489487453433187 537 2967153
SGTC_401 neomycin 50 µM 0.0260563600112237 0.497147115417614 no 1690 0.489606192449512 511 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2137 5261020 140 µM 0.025120260515234 0.496733577871207 no 1691 0.489979519863258 533 763655
SGTC_542 3381-0244 89.3 µM 0.0249859300966059 0.496674235448597 no 1692 0.49003309313128 542 1112843
SGTC_3334 9142812 21.919 µM 0.0248700422231511 0.496623040348515 no 1693 0.490079311341429 526 45283678
SGTC_1430 4049-0248 69.1 µM 0.0230283765814677 0.495809466642383 no 1694 0.490813818854514 535 22774488
SGTC_634 1611-4317 11.2 µM 0.0222280855598388 0.495455935534885 no 1695 0.491133007042634 528 2843522
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.0220494514083264 0.495377023806936 no 1696 0.491204254296129 542 229346 A bile salt which induces apoptosis.
SGTC_1467 k284-1082 293 µM 0.0220454066746402 0.495375237045841 no 1697 0.491205867519277 526 3334705
SGTC_2742 clothiapine 36.27 µM 0.021277385374646 0.495035965360802 no 1698 0.491512191805995 538 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2185 6113692 200 µM 0.0212742259795923 0.495034569712378 no 1699 0.491513451937025 530 874150
SGTC_3185 9108267 49.47 µM 0.020050407225477 0.494493958069376 no 1700 0.492001580741273 535 4910486
SGTC_2807 7945238 51.95 µM 0.0196967818419711 0.494337748869274 no 1701 0.492142629000498 539 17148797
SGTC_2419 paclitaxel 166.5 µM 0.0179451768341041 0.493564014464186 no 1702 0.492841294452566 542 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_853 0419-0306 21 µM 0.0177822658277097 0.493492053164288 no 1703 0.492906276171819 539 762713
SGTC_2523 spermine 47.74 µM 0.0165441037174706 0.492945137385661 no 1704 0.493400158607997 531 1103 A DNA binding polyamine.
SGTC_2879 9041815 71.43 µM 0.0157928317410106 0.492613295075308 no 1705 0.493699833583463 543 4942971
SGTC_1020 4335-0961 93.3 µM 0.0154463602610835 0.492460257804613 no 1706 0.493838038844947 534 669075
SGTC_3337 9144342 33.5465 µM 0.014870240775263 0.492205786935437 no 1707 0.494067850859288 541 17682949
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.0143288900190135 0.491966676235998 no 1708 0.494283795546606 534 23847180
SGTC_2058 5236698 133 µM 0.0138032279450548 0.491734497875172 no 1709 0.494493483625857 540 766665
SGTC_2061 5245884 80.95 µM 0.0137226945608361 0.491698927532436 no 1710 0.494525608755097 540 573863
SGTC_3033 9090887 49.47 µM 0.0136563964137249 0.491669644721961 no 1711 0.494552055410871 530 19325384
SGTC_2245 6637752 200 µM 0.013539165504289 0.491617865850889 no 1712 0.49459881945366 532 681890
SGTC_2795 7780010 54.55 µM 0.0132284885962838 0.491480645903655 no 1713 0.494722750507124 541 953673
SGTC_427 1354-0053 47.3 µM 0.0131559466858004 0.491448605697412 no 1714 0.494751688024137 526 6813657
SGTC_1503 4585-0012 61.3 µM 0.0130423175299762 0.491398418246974 no 1715 0.494797015609672 533 2922052
SGTC_16 erodoxin 22.806 µM 0.0117776865910575 0.490839868487761 no 1716 0.495301491478503 539 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_1174 0739-0097 51.1 µM 0.011102386018859 0.490541615657433 no 1717 0.495570879795015 539 728447
SGTC_272 doxorubicin 8.13 µM 0.0109772248571353 0.490486337632597 no 1718 0.495620808831558 540 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_3323 9138564 53.9225 µM 0.00802655211892879 0.489183214169921 no 1719 0.496797903376751 541 43912313 YNL103W MET4
SGTC_1574 spiramycin 23.7 µM 0.00778564267206318 0.489076824782834 no 1720 0.496894009336956 543 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_157 1348-1695 65.819 µM 0.00742309876191251 0.488916721177889 no 1721 0.497038639248648 538 5380510
SGTC_2876 9059903 25.97 µM 0.00621103038460207 0.488381470805941 no 1722 0.497522173305879 544 6916095
SGTC_1884 5633444 25 µM 0.00545255297369759 0.488046537153407 no 1723 0.49782475686112 545 5724239
SGTC_206 4546-0025 72.014 µM 0.00431146658195854 0.487542664361802 no 1724 0.498279979018759 547 6620745 YIL048W NEO1
SGTC_3207 9114163 49.47 µM 0.00412318436123639 0.487459525931115 no 1725 0.498355092089165 546 849233
SGTC_2286 7945697 125 µM 0.00400861367258489 0.487408936039794 no 1726 0.498400798803135 543 1245733
SGTC_126 0417-1624 672.48 µM 0.00272460019404982 0.486841980446258 no 1727 0.498913043130231 546 41912 YDL195W SEC31
SGTC_755 1995-0008 37.3 µM 0.00118613521766195 0.486162707023697 no 1728 0.49952680062236 547 689533
SGTC_2982 9019404 25.97 µM 0.000502890420838812 0.485861048933939 no 1729 0.499799375757175 548 22333232
SGTC_3265 9137266 49.47 µM -0.000390957089887462 0.485466420289412 no 1730 0.499844030690994 550 17224265
SGTC_2860 9025725 38.96 µM -0.00041653937073787 0.485455126064086 no 1731 0.499833824838366 549 40546248
SGTC_2950 9072895 21.46 µM -0.000620685472001545 0.485364998785504 no 1732 0.499752382338287 549 17332245
SGTC_1445 4239-0156 97.7 µM -0.00145166807926647 0.484998140856121 no 1733 0.499420868429476 551 4008346
SGTC_2684 capsaicin 100 µM -0.0016947415736704 0.484890832405924 no 1734 0.499323896255554 550 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_121 0557-0495 61.343 µM -0.00203357011918912 0.484741253275528 no 1735 0.499188723458454 549 3104427
SGTC_1706 st031321 9.9705 µM -0.0027835309655025 0.484410183490371 no 1736 0.498889533243046 549 6103185
SGTC_584 0986-0246 15.4 µM -0.0035715195740963 0.484062337953787 no 1737 0.498575172865736 549 53315 YDR232W HEM1
SGTC_1931 st074438 57.1 µM -0.0036092461175431 0.484045684449513 no 1738 0.49856012224947 551 2787313
SGTC_3107 9121808 49.47 µM -0.00559941372249446 0.483167211462802 no 1739 0.49776616879369 550 662681
SGTC_3121 9125696 49.47 µM -0.00594811640104977 0.483013300113549 no 1740 0.497627058871358 550 1235365
SGTC_2663 amphotericin b 100 µM -0.00636880537595563 0.482827618625643 no 1741 0.497459231436203 549 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3345 9148410 3.559 µM -0.0074217199685 0.482362905133623 no 1742 0.497039189292484 553 4903596
SGTC_1214 0358-0031 63.7 µM -0.00750833730311478 0.482324676838341 no 1743 0.497004634938314 561 4301366
SGTC_1971 st069429 63.5 µM -0.00753333014496391 0.482313646354351 no 1744 0.496994664518975 552 1246522 YGL099W LSG1
SGTC_2783 7738165 71.43 µM -0.00968420462351487 0.481364418704644 no 1745 0.496136621710777 550 17201110
SGTC_2142 5622915 118.518 µM -0.0100382977502105 0.481208159696947 no 1746 0.495995365860405 551 5322196
SGTC_160 3453-0671 289.699 µM -0.0102332517682723 0.481122128979965 no 1747 0.495917594454973 555 5322268
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.0103613667765266 0.481065593942395 no 1748 0.495866486671129 556 15053
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -0.0122634289453366 0.480226290729186 no 1749 0.495107722317632 552 23665772 A membrane-active detergent.
SGTC_1373 2887-0003 58.5 µM -0.0128237119300585 0.479979077023435 no 1750 0.494884219332761 558 776948
SGTC_672 1441-0018 53.7 µM -0.0128979804557972 0.479946308091909 no 1751 0.494854592927972 555 251141
SGTC_2846 9008642 19.48 µM -0.0129049489657579 0.479943233436701 no 1752 0.494851813126073 558 2992898
SGTC_2155 5570423 76 µM -0.013700499220565 0.47959222758805 no 1753 0.494534462582425 557 797402
SGTC_137 0438-0332 85.389 µM -0.0139056673822884 0.479501707610329 no 1754 0.494452620125157 558 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_2174 5790901 200 µM -0.0144745382714566 0.479250727914539 no 1755 0.494225696326165 559 786020
SGTC_2958 9077254 16.72 µM -0.0146222344366526 0.479185567301945 no 1756 0.494166780316549 557 16457351
SGTC_1286 0929-0070 131 µM -0.0147338972577822 0.479136304253757 no 1757 0.494122238094546 554 1420408
SGTC_518 1021-0119 62.6 µM -0.014887630720938 0.479068481135174 no 1758 0.494060914042593 567 1097762
SGTC_2890 9046729 58.44 µM -0.0149576438775066 0.479037593391792 no 1759 0.494032985944018 560 903329
SGTC_1999 st074831 12.5 µM -0.0150241438235204 0.479008255690043 no 1760 0.494006459284708 564 17112523
SGTC_1025 k007-0731 70 µM -0.0160565845641503 0.478552789730035 no 1761 0.493594624772172 553 6256118
SGTC_3157 9099274 49.47 µM -0.0179174296820659 0.477731940518671 no 1762 0.492852362185218 551 17217662
SGTC_2870 9038528 12.99 µM -0.0193673755721905 0.477092410973704 no 1763 0.492274018023365 581 6463316
SGTC_519 k048-0011 62.8 µM -0.0197089814515567 0.476941746943793 no 1764 0.49213776300502 560 6836379
SGTC_2413 inermin 26.06 µM -0.0202504855698281 0.476702925285039 no 1765 0.491921777233824 578 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_923 1900-2434 73.3 µM -0.0205157042477188 0.476585957911704 no 1766 0.491815992267524 556 5910570
SGTC_2407 paclitaxel 400 µM -0.0230617874246316 0.475463182348489 no 1767 0.490800493395437 578 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_871 0574-0004 149 µM -0.0232377423256333 0.475385596588029 no 1768 0.490730316352939 557 9551173
SGTC_935 2996-0153 430 µM -0.0232641986388875 0.475373930990871 no 1769 0.490719764663546 561 23738523
SGTC_2960 9079389 5.97 µM -0.0235709170252692 0.475238688704332 no 1770 0.490597435277738 562 16457355
SGTC_1620 st003704 16.5 µM -0.0237277055540317 0.475169556554458 no 1771 0.490534903193824 557 2834414
SGTC_925 2064-1272 59.6 µM -0.0238125751584874 0.47513213564498 no 1772 0.490501054684182 581 6815817
SGTC_1046 2001-0062 216 µM -0.0244670849576242 0.474843555009042 no 1773 0.490240019124917 558 739778
SGTC_2778 tioconazole 65.09 nM -0.0245358348053391 0.47481324320135 no 1774 0.490212600135238 565 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_565 1418-0001 44.5 µM -0.0247375719299544 0.47472429814581 no 1775 0.490132143087936 571 2862145
SGTC_515 4092-1064 102 µM -0.0248015425009182 0.47469609405115 no 1776 0.49010663035011 571 717353
SGTC_1173 0443-0020 122 µM -0.0285490973158652 0.473044054223444 no 1777 0.488612104986872 560 5331295
SGTC_776 4476-4378 112 µM -0.0287996122987137 0.472933635567885 no 1778 0.488512205046839 563 2892008
SGTC_1902 st060212 70.5 µM -0.0293427700125417 0.472694236903863 no 1779 0.488295608018643 559 688944
SGTC_1268 0828-0275 2.46 µM -0.0308950109350575 0.47201013594728 no 1780 0.487676634361297 573 745337
SGTC_3174 9107204 49.47 µM -0.0312283951456489 0.471863218132029 no 1781 0.48754369745088 570 3938802
SGTC_1573 oleylamine 1.06 µM -0.0314302131039349 0.471774281605388 no 1782 0.487463223237943 565 5356789 An amine of the fatty acid oleic acid.
SGTC_98 0074-0023 107.663 µM -0.0333773283465327 0.470916305704348 no 1783 0.486686844472993 586 3563821
SGTC_1119 parthenolide 318.541 nM -0.0333814144691565 0.470914505337824 no 1784 0.486685215253792 595 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_1426 4048-4480 71.7 µM -0.0334560583823753 0.470881616952593 no 1785 0.486655453264755 569 14224343
SGTC_2385 9074692 200 µM -0.0341067234378179 0.470594939949129 no 1786 0.486396023538888 559 17046906
SGTC_2256 7954252 200 µM -0.0352520499203102 0.470090356808 no 1787 0.485939379081659 587 2972920
SGTC_2394 5221648 200 µM -0.0364947071805657 0.469542948123723 no 1788 0.485443949478936 563 788586
SGTC_839 0122-0028 230 µM -0.036533832282412 0.469525713873856 no 1789 0.485428351223566 562 759448
SGTC_1997 st073024 93.8 µM -0.0368390605044542 0.469391265593595 no 1790 0.485306664697318 565 686268
SGTC_2184 6075246 200 µM -0.0378650745156864 0.468939348065592 no 1791 0.48489762978347 562 2267320
SGTC_324 1315-0088 19.6 µM -0.0380680221866385 0.468849962575825 no 1792 0.484816723709362 566 6787421
SGTC_1656 st012921 11 µM -0.0381157896776329 0.468828924274353 no 1793 0.48479768105797 559 6732821
SGTC_161 4065-0411 162.148 µM -0.039851157183361 0.468064673475058 no 1794 0.484105895531508 575 1906281 YLR208W SEC13
SGTC_2757 clomiphene 4.22 µM -0.0400489230123926 0.467977585396833 no 1795 0.484027061315853 564 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_1643 st009866 20.2 µM -0.0412444704738173 0.46745114739847 no 1796 0.483550500751981 563 3156273 YOR207C RET1
SGTC_3132 9126706 49.47 µM -0.0417131102907452 0.467244805694074 no 1797 0.483363701278892 567 850858
SGTC_3058 9093861 49.47 µM -0.0425863261157694 0.466860353046634 no 1798 0.48301564789039 568 17217477
SGTC_791 1348-1292 225 µM -0.0440771127617375 0.46620407277801 no 1799 0.482421468210304 570 5437054
SGTC_2015 5119600 184 µM -0.0444824281507011 0.466025658971985 no 1800 0.48225992920811 567 2828786
SGTC_1246 0422-0085 105 µM -0.0449114939822314 0.465836798014714 no 1801 0.482088927608555 573 264295
SGTC_300 r073-0011 5.04 µM -0.0449123058326271 0.465836440671601 no 1802 0.482088604053589 567 2735780
SGTC_1710 st031758 61.5 µM -0.0449568986275257 0.465816812801923 no 1803 0.482070832053251 562 5394341
SGTC_2400 5203494 178.7 µM -0.0452635643868128 0.465681833708802 no 1804 0.481948614531915 569 6777674
SGTC_2014 4013930 200 µM -0.0487760665875064 0.464136089457651 no 1805 0.48054887778149 578 64556
SGTC_2273 7815444 169.05 µM -0.0493635647384204 0.463877601775917 no 1806 0.480314781935984 570 2824616
SGTC_1709 st033179 39.1045 µM -0.0494244220554974 0.463850826617799 no 1807 0.480290532978082 574 573381
SGTC_3158 9100007 49.47 µM -0.0495355809114901 0.463801920909137 no 1808 0.480246241262859 572 19297233
SGTC_572 0960-0087 17.7 µM -0.0514212737553959 0.462972371041016 no 1809 0.479494916595304 572 6796365
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.0521704606239803 0.462642834881378 no 1810 0.479196434938199 575 6708561
SGTC_865 0488-0499 301 µM -0.05243850515038 0.462524939452328 no 1811 0.479089646817136 565 9634651
SGTC_3153 9100258 49.47 µM -0.0527257267705095 0.462398612915658 no 1812 0.478975220266586 572 25236848
SGTC_2725 haloperidol 53.21 µM -0.0536474179318156 0.46199325806241 no 1813 0.478608038417416 569 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2504 purpurogallin 52.29 µM -0.055171724626203 0.46132296293699 no 1814 0.478000827546921 573 5281571 An antioxidant.
SGTC_872 0588-0139 234 µM -0.0557594979749742 0.461064526078218 no 1815 0.477766700325772 569 2047100
SGTC_1431 4049-0260 9.09 µM -0.0558131923327442 0.461040918134134 no 1816 0.477745312682564 565 3854841
SGTC_668 1682-0499 62.6 µM -0.0562171610850765 0.460863308503896 no 1817 0.477584405106366 570 682214
SGTC_1212 0520-0165 585 µM -0.0562499935064396 0.460848873684862 no 1818 0.477571327558682 587 5403258
SGTC_1982 st072467 71.9 µM -0.0567053814510519 0.460648667079373 no 1819 0.477389943568865 590 3163533
SGTC_1933 st074711 15.9 µM -0.057675813206005 0.460222060123137 no 1820 0.477003429941365 575 17250958
SGTC_665 3914-0008 307 µM -0.0580879025406551 0.460040917282657 no 1821 0.476839305248294 589 1069549
SGTC_3200 9114385 49.47 µM -0.0585461186350113 0.459839508159959 no 1822 0.476656814055026 583 17018030 YLR208W SEC13
SGTC_1993 st073995 70.8 µM -0.059253338196698 0.459528669678829 no 1823 0.476375163248554 573 3098394
SGTC_392 N-ethylmaleimide 8.33 µM -0.0606698177939236 0.458906170463632 no 1824 0.475811084648496 574 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_1189 1431-2119 7.28 µM -0.0616117459386906 0.458492277696041 no 1825 0.475436011404363 568 3107275
SGTC_2939 9044578 71.43 µM -0.0621925277568853 0.458237098679774 no 1826 0.475204756479289 580 2653634
SGTC_387 norethindrone acetate 66.7 µM -0.0652995281664786 0.456872265942663 no 1827 0.473967759006487 596 541197
SGTC_3170 9103054 49.47 µM -0.0657066132472521 0.456693480309128 no 1828 0.47380570359207 603 16432970
SGTC_2146 5545642 200 µM -0.0665192412641303 0.456336612579464 no 1829 0.473482219660915 582 825326
SGTC_2298 7976326 193.81 µM -0.0666191646556264 0.456292733385098 no 1830 0.473442444224576 574 2235818
SGTC_1124 fisetin 1.16336 µM -0.0674638275260657 0.45592183931821 no 1831 0.473106228922763 614 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_3040 9091894 49.47 µM -0.0689063873433132 0.455288495844003 no 1832 0.472532067120922 567 25236966
SGTC_2234 tolnaftate 200 µM -0.0713132386870711 0.454232042192457 no 1833 0.471574229553671 585 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_566 0958-0068 16.5 µM -0.0728782239114645 0.453545287071072 no 1834 0.470951511328339 603 6815365
SGTC_1761 st044296 37 µM -0.0734611731472635 0.453289509588392 no 1835 0.470719569950321 584 1826700
SGTC_2517 totarol 10 µM -0.0736220669065662 0.453218918511465 no 1836 0.470655555967067 584 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_1151 3909-8316 15.3 µM -0.0740140031215602 0.453046965270034 no 1837 0.47049962147148 591 800431
SGTC_1853 st056710 91.2 µM -0.0747711540457274 0.452714807209121 no 1838 0.470198396644279 601 269167
SGTC_973 1325-0077 65.9 µM -0.0751136687981071 0.452564558674155 no 1839 0.470062136210496 582 2835149
SGTC_579 4491-1009 110 µM -0.0752068318245664 0.452523692679294 no 1840 0.470025074370602 575 1271041
SGTC_1441 4106-0040 13 µM -0.0760130018434298 0.452170086963098 no 1841 0.469704377075634 570 2904180
SGTC_910 3454-3003 490 µM -0.0768069251522919 0.451821890025454 no 1842 0.469388570770356 583 820824
SGTC_230 MPP+ 141.667 µM -0.0770883520365722 0.451698471395256 no 1843 0.469276629577268 601 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_1471 k673-0312 37 µM -0.0772323532283797 0.451635322055428 no 1844 0.469219352174326 575 24099884
SGTC_3306 9127676 59.7925 µM -0.0773375378027045 0.451589195874233 no 1845 0.469177514733901 582 41905287
SGTC_803 4488-1585 147 µM -0.0773636368217671 0.45157775087436 no 1846 0.46916713383327 588 747204
SGTC_2283 7944793 200 µM -0.0773808623845356 0.451570197104319 no 1847 0.469160282366734 576 2970533
SGTC_2423 st077119 87.2 µM -0.0780002493302318 0.451298594628444 no 1848 0.468913927330728 574 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_2181 6316240 54.2555 µM -0.0781647944414728 0.451226445079211 no 1849 0.468848483135998 587 12779990
SGTC_3016 9080866 49.47 µM -0.0787131902059107 0.450985996788404 no 1850 0.468630376883517 589 17066299
SGTC_2326 6164455 177.58 µM -0.0789474250569565 0.450883300214074 no 1851 0.468537220594956 590 2888790
SGTC_994 3910-0338 138 µM -0.0791126047718515 0.450810881750938 no 1852 0.468471528890312 580 3479481
SGTC_1008 4106-0037 6 µM -0.079259244847038 0.450746592850443 no 1853 0.468413211089569 589 2905394
SGTC_1570 verbenone 133 µM -0.0795529112508926 0.450617849597595 no 1854 0.468296423916711 579 29025 A natural terpanoid with antifungal properties.
SGTC_1908 st060353 56.5 µM -0.0816460987549926 0.449700348190925 no 1855 0.46746407106624 611 4227716
SGTC_2109 5483026 200 µM -0.0817764983548279 0.449643199319962 no 1856 0.467412222531293 576 759335
SGTC_2997 9067075 71.4286 µM -0.0827379980483892 0.449221845208997 no 1857 0.467029935182648 584 27209819
SGTC_1744 st037937 38.9 µM -0.0831451435202213 0.449043440728174 no 1858 0.466868065375251 600 1016152
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.0837954465479016 0.4487585099694 no 1859 0.466609534208364 580 676296 Flavone; oxidizing agent.
SGTC_2913 7966556 36.57 µM -0.0843205947801921 0.448528435158277 no 1860 0.466400769222458 596 2976516
SGTC_624 k048-0052 28 µM -0.0846791870568989 0.448371340789866 no 1861 0.466258221424279 586 6835531
SGTC_1107 amlodipine 47 µM -0.0852888780001446 0.448104262128835 no 1862 0.466015866692448 594 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1785 bathophenanthroline 24 µM -0.0853136814859598 0.448093397314844 no 1863 0.466006007467962 585 72812 An iron chelator.
SGTC_209 4077-0173 175.592 µM -0.085597070492856 0.447969265559074 no 1864 0.465893363661019 579 15993494
SGTC_2072 5231554 129 µM -0.0862619065317276 0.447678070100496 no 1865 0.465629109872325 587 789545
SGTC_28 pentachloropyridine N-oxide 1.606 µM -0.0863762920005277 0.447627972572894 no 1866 0.465583646362483 580 140250 A respiratory chain inhibitor.
SGTC_2605 digitonin 300 nM -0.0875842174144792 0.447098987319824 no 1867 0.465103573323307 579 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2585 alliin 100 µM -0.0879843348605179 0.446923785092287 no 1868 0.464944563411336 592 87310 A garlic compound which reacts with lipids.
SGTC_1079 idarubicin 2.36 µM -0.0880541648459688 0.446893209208318 no 1869 0.464916812982852 591 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2473 5854593 8.94 µM -0.088408097923499 0.446738240288192 no 1870 0.464776162644005 586 2872951
SGTC_1466 k213-0079 57.5 µM -0.0898282838096914 0.446116496645352 no 1871 0.464211835906683 594 3657981
SGTC_892 0929-0076 29 µM -0.0901814344783148 0.445961911204222 no 1872 0.464071518673086 575 5751038
SGTC_2994 9053520 71.4286 µM -0.0904347903795773 0.445851014211071 no 1873 0.46397085561199 615 4647384
SGTC_1493 4348-0038 111 µM -0.0910210252626056 0.445594428249771 no 1874 0.463737942328714 584 800424
SGTC_1451 4152-0210 104 µM -0.0910574590427944 0.445578482497412 no 1875 0.463723467462709 623 659563
SGTC_50 0929-0078 56.389 µM -0.0912624021019963 0.445488787948552 no 1876 0.463642046026767 596 1377751
SGTC_362 0310-0100 9.03 µM -0.0916325919447695 0.445326779236675 no 1877 0.463494977874323 592 790235
SGTC_2857 9024691 58.44 µM -0.0920234893012989 0.445155718065012 no 1878 0.463339688504856 626 16478292
SGTC_1164 k060-0068 93.7 µM -0.0942315401905371 0.444189642310735 no 1879 0.46246261539436 580 5963676
SGTC_1309 pyrazolanthrone 13.4 µM -0.0942754720575175 0.44417042439922 no 1880 0.462445166791832 608 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_2961 9083290 32.55 µM -0.0949452259424512 0.443877458119626 no 1881 0.462179166821251 599 17741490
SGTC_2679 rapamycin 1 nM -0.0949524759403688 0.443874286965589 no 1882 0.4621762874988 600 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_1404 3909-7820 48.3 µM -0.0953639008086435 0.443694335342011 no 1883 0.462012894171873 593 23741373
SGTC_33 0986-0033 35.816 µM -0.0959093803654016 0.443455767933071 no 1884 0.461796272236796 581 2848082
SGTC_2052 5265182 7.135 µM -0.0962880606597658 0.443290162816456 no 1885 0.461645896619785 592 1239884
SGTC_2075 5212009 200 µM -0.0969893502469612 0.442983499827919 no 1886 0.461367425923405 582 780898
SGTC_3284 9108171 64.8615 µM -0.0983466576516148 0.442390067662898 no 1887 0.460828515138266 579 8687505
SGTC_259 usnic acid 108.925 µM -0.0987822289757815 0.442199657635745 no 1888 0.460655589348347 639 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2028 5153890 36.43 µM -0.0993491074914043 0.441951866667288 no 1889 0.460430544552996 610 2830968 YPR165W RHO1
SGTC_1757 st041620 31.8375 µM -0.100469156837885 0.441462343425111 no 1890 0.459985934096394 593 5289815
SGTC_2373 9071805 200 µM -0.10126942826493 0.441112635460314 no 1891 0.459668292056759 636 10149009
SGTC_831 k061-1017 217 µM -0.101553466531506 0.440988525542599 no 1892 0.459555558368835 607 1240153
SGTC_3150 9097574 49.47 µM -0.101778175976418 0.440890343333083 no 1893 0.459466374363881 621 17217476
SGTC_1249 0481-0015 10.2 µM -0.102646542593419 0.440510962449815 no 1894 0.459121751128884 591 4227577
SGTC_2827 7993847 71.43 µM -0.102736760380648 0.440471550305878 no 1895 0.459085948716216 593 2985692
SGTC_3332 9141069 11.198 µM -0.102804705476522 0.440441868500775 no 1896 0.459058985312726 600 17332883
SGTC_1271 0832-2808 169 µM -0.103340484420648 0.440207825285264 no 1897 0.458846372839657 621 3663794
SGTC_3129 9127257 49.47 µM -0.103438888649334 0.440164841836494 no 1898 0.458807324493231 649 837894
SGTC_2608 thymoquinone 42.66 µM -0.103788004175155 0.440012352158075 no 1899 0.458668793167917 588 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_458 nppb 133 µM -0.104533233763483 0.439686874174009 no 1900 0.458373098004663 596 4549 A chloride channel blocker.
SGTC_6 0844-0013 19.835 µM -0.105461145939824 0.439281666822861 no 1901 0.458004949531265 598 1584900
SGTC_567 1080-0542 68.4 µM -0.108208159644531 0.438082455669698 no 1902 0.456915286251883 587 5950415
SGTC_852 0418-0143 439 µM -0.108728842431193 0.437855214902058 no 1903 0.456708782258769 592 5369229
SGTC_1044 1222-0021 1.78 µM -0.109310127918375 0.437601549605944 no 1904 0.456478256908224 606 4306703
SGTC_208 k072-0098 12.366 µM -0.109491003940229 0.437522622929279 no 1905 0.456406528343682 591 5948901
SGTC_1343 1487-0095 224 µM -0.110289847004452 0.437174071243556 no 1906 0.456089754529599 620 4560101 YGL055W OLE1
SGTC_2490 carminic acid 95.39 µM -0.110529346093816 0.437069582344851 no 1907 0.455994788813858 593 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2359 9039622 200 µM -0.11053046351204 0.437069094846809 no 1908 0.455994345743232 595 6463596
SGTC_1610 st001799 48.1 µM -0.11159978525972 0.436602623845691 no 1909 0.455570371148816 593 621897
SGTC_2333 9017922 200 µM -0.111826660986377 0.436503664995951 no 1910 0.455480423848167 597 3163164
SGTC_2999 9069765 71.4286 µM -0.112354174554576 0.436273589045736 no 1911 0.455271294299255 597 2097066
SGTC_380 3970-0968 6 µM -0.112571827098161 0.436178665793099 no 1912 0.455185010879517 594 2891601
SGTC_156 3474-0145 5.642 µM -0.11353844659377 0.435757145407327 no 1913 0.45480184207887 593 2265471
SGTC_2037 5169046 200 µM -0.114223746755086 0.435458346047765 no 1914 0.454530213957663 608 5718022
SGTC_1729 st035615 45.989 µM -0.11443446523697 0.43536647757779 no 1915 0.45444669706437 586 17385451
SGTC_84 0443-0269 128.823 µM -0.114519926229739 0.435329219520857 no 1916 0.454412825732155 594 6150058
SGTC_2840 9008771 71.43 µM -0.115112831222087 0.435070749138486 no 1917 0.454177844834839 575 2992978
SGTC_2361 9034121 116 µM -0.115194363425516 0.435035208242243 no 1918 0.454145533135692 612 6496917
SGTC_2112 5488546 200 µM -0.115466213255739 0.434916709331931 no 1919 0.454037799618442 611 600757
SGTC_1333 1482-0047 286 µM -0.115546103457841 0.434881886430296 no 1920 0.454006139941562 624 3811116
SGTC_1806 st050005 60.3 µM -0.115958677338914 0.434702059911749 no 1921 0.453842645752758 596 5194765
SGTC_3005 9076496 71.4286 µM -0.116969631879744 0.43426147737668 no 1922 0.453442059250606 604 21368410
SGTC_1562 morin hydrate 59.1 µM -0.117169941876918 0.434174190260178 no 1923 0.453362692862893 618 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_2425 5628681 7.85 µM -0.117192569749823 0.434164330136318 no 1924 0.453353727413761 589 5714958
SGTC_1150 3909-7983 10.9 µM -0.117736582873555 0.43392728808246 no 1925 0.453138189708131 598 23965914
SGTC_586 0957-0265 8.15 µM -0.118086095603964 0.433775007934742 no 1926 0.452999720232959 608 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2248 tofa 1.1 µM -0.118125099958621 0.433758014631106 no 1927 0.452984267895274 598 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1775 st081588 35.1725 µM -0.119011566131465 0.43337183470411 no 1928 0.452633096230831 602 1426443 YGL099W LSG1
SGTC_2272 7805186 180 µM -0.119341181794179 0.433228257212782 no 1929 0.452502529130218 596 2956062 YPR165W RHO1
SGTC_3213 9129884 49.47 µM -0.119440469199943 0.433185010276234 no 1930 0.452463200485972 624 17190742
SGTC_1359 1582-0056 520 nM -0.119555330340677 0.4331349808358 no 1931 0.452417703525581 616 3661189
SGTC_319 1348-1596 45.5 µM -0.119674848900493 0.433082923926402 no 1932 0.45237036240603 628 5380505
SGTC_1794 st048918 76.9 µM -0.120990443304333 0.432509987101759 no 1933 0.451849302361633 599 672303
SGTC_1786 berberine 21.6 µM -0.121069322415854 0.432475640017053 no 1934 0.4518180637839 628 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_1290 0986-0249 10.2 µM -0.121493316303612 0.432291025059121 no 1935 0.451650154153622 609 53329
SGTC_2926 9010726 65.15 µM -0.122276582145452 0.431950015204547 no 1936 0.4513399887775 638 2994293
SGTC_2101 5377231 179.231 µM -0.122440013943215 0.431878868411249 no 1937 0.451275275172773 627 2844213
SGTC_2048 5246248 200 µM -0.124045144243527 0.431180224518855 no 1938 0.450639765563904 595 677046
SGTC_1245 0418-0076 17.2 µM -0.124933937113412 0.430793463831709 no 1939 0.450287925458061 638 6790114
SGTC_637 1181-0519 7.26 µM -0.126868436979153 0.429951890749906 no 1940 0.449522264189627 610 6252091 YGR060W ERG25
SGTC_1241 0364-0022 50.8 µM -0.127056740284 0.429869989353472 no 1941 0.44944774507219 624 4563895
SGTC_1579 chlormadinone acetate 49.4 µM -0.127677307360047 0.429600098793601 no 1942 0.449202174597882 633 45114258 A steroidal progestin.
SGTC_2627 acetyl isogambogic acid 100 µM -0.12890614254397 0.429065763804714 no 1943 0.448715958088964 633 6857789 A caspase activator and apoptosis inducer.
SGTC_2337 9009472 200 µM -0.131472180486274 0.427950392454184 no 1944 0.4477008961433 595 5742383
SGTC_2306 7482397 179.52 µM -0.132582267638769 0.4274680522825 no 1945 0.447261878487986 633 891448
SGTC_2079 5212404 121 µM -0.133181828716042 0.427207584084926 no 1946 0.447024790700863 612 758462
SGTC_2083 5306046 65.942 µM -0.13476707973117 0.42651905431093 no 1947 0.446398017452599 610 539837
SGTC_591 4299-0174 154 µM -0.13651504930665 0.425760109789165 no 1948 0.445707064149076 609 5509088
SGTC_1133 3473-0247 50 µM -0.137258561687159 0.425437370049119 no 1949 0.44541321167197 590 711311
SGTC_1401 3807-4679 7.6 µM -0.139361398108164 0.424524853576204 no 1950 0.444582287243841 595 3291456
SGTC_77 0828-0286 12.516 µM -0.141042211348346 0.423795762715013 no 1951 0.443918297897168 619 745345
SGTC_1281 0884-0031 11.8 µM -0.141609375382859 0.423549801173353 no 1952 0.443694280541816 603 1548255
SGTC_1266 0828-0227 32.9 µM -0.141832303561 0.423453132250302 no 1953 0.443606233722114 614 3913820
SGTC_1797 st048695 56.8 µM -0.143221108533584 0.422851005134721 no 1954 0.443057779738363 612 592262 YIL048W NEO1
SGTC_2321 7390090 138.78 µM -0.144983918297941 0.422086985033847 no 1955 0.442361784481898 625 649046
SGTC_2983 9022671 12.99 µM -0.14519913612749 0.42199372740643 no 1956 0.442276823988474 653 6405161
SGTC_2199 6590217 200 µM -0.14655624278917 0.421405770449304 no 1957 0.441741146917819 624 703109
SGTC_204 PMA1.184 62.41 µM -0.146647864186184 0.421366082419399 no 1958 0.441704985952836 614 2252213 YGL008C PMA1
SGTC_1640 st009078 66.4 µM -0.14740223673001 0.421039338062889 no 1959 0.441407270076433 624 690618
SGTC_1439 4092-1168 46 µM -0.147576524031736 0.420963856041074 no 1960 0.441338491658438 610 2886240
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.148225627762987 0.420682761531225 no 1961 0.441082353591809 637 7104
SGTC_1949 st076024 69.1 µM -0.148343713302051 0.42063162890647 no 1962 0.441035759368803 607 2921930
SGTC_112 phenothiazine 287.218 µM -0.148391177198068 0.420611076779125 no 1963 0.44101703128218 619 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2157 5649910 96.377 µM -0.148609150154078 0.420516696073155 no 1964 0.440931026206363 641 2858091
SGTC_237 nikkomycin 200 µM -0.148826724419815 0.420422492553851 no 1965 0.440845181219083 631 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_631 k072-0230 41.5 µM -0.150103594931348 0.419869735675784 no 1966 0.440341441888139 640 5773147
SGTC_2828 7998861 71.43 µM -0.150162837859449 0.419844093257301 no 1967 0.440318072244699 603 2988188
SGTC_2295 7971645 200 µM -0.150338951274507 0.419767867200241 no 1968 0.440248601759352 631 2978226 YKL099C UTP11
SGTC_1670 st016595 4.04 µM -0.150887964155807 0.419530260753139 no 1969 0.440032047496636 610 597879
SGTC_3108 9121785 49.47 µM -0.152656108170538 0.418765228209361 no 1970 0.439334737785968 594 17140271
SGTC_2909 7941780 10.49 µM -0.15336484949824 0.418458659282955 no 1971 0.439055281476966 639 1243215
SGTC_2082 5219693 150 µM -0.153906759329296 0.418224287394013 no 1972 0.438841627217427 627 2834649
SGTC_958 1222-0007 33 µM -0.154088540016135 0.418145675125541 no 1973 0.438769962053521 645 7312461
SGTC_2364 9055074 200 µM -0.154295474255171 0.418056189016037 no 1974 0.438688382804004 631 6470630
SGTC_34 0469-0683 81.75 µM -0.154371695014599 0.418023229375832 no 1975 0.438658335110646 614 3690923
SGTC_2310 7668677 200 µM -0.155538068892018 0.417518933961899 no 1976 0.438198572234998 614 2197143
SGTC_2588 indole-3-carbinol 100 µM -0.156612686287809 0.417054430558408 no 1977 0.437775051859782 628 3712 Induces cell cycle arrest.
SGTC_2712 st079126 47.7 µM -0.156728440539268 0.417004402674189 no 1978 0.437729435881526 632 3152970
SGTC_279 1273-0055 2.93 µM -0.157025524386475 0.416876012019302 no 1979 0.437612366041245 620 2847562
SGTC_561 1550-0330 72.9 µM -0.157295084344386 0.416759524027939 no 1980 0.437506147080906 644 6812934
SGTC_2480 5767542 37.17 µM -0.157354917273006 0.416733668739036 no 1981 0.437482570779166 613 2867358
SGTC_663 1486-0733 13.9 µM -0.158401018170698 0.416281680953947 no 1982 0.437070405761914 616 722445 YPR165W RHO1
SGTC_963 1269-2853 151 µM -0.158657581849165 0.416170844617355 no 1983 0.4369693297742 599 3668223
SGTC_3080 9117754 49.47 µM -0.158662440381525 0.416168745779993 no 1984 0.436967415743417 603 9550191
SGTC_1521 st012942 49.4 µM -0.15867393098642 0.416163781963172 no 1985 0.436962888997205 598 24207259
SGTC_276 colchicine 750 µM -0.158706772090091 0.416149595035929 no 1986 0.436949951225858 613 2833 A microtubule depolymerizer.
SGTC_1438 4092-1045 4 µM -0.159732288030398 0.415706640625564 no 1987 0.436545982640454 614 1351342
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -0.16054366703906 0.415356254918189 no 1988 0.436226413186307 612 688801
SGTC_2545 solidagenone 89.61 µM -0.160882687310919 0.415209872408028 no 1989 0.436092899097814 615 6708572 An anti ulcer agent
SGTC_1939 st074455 53.6 µM -0.162219492880225 0.414632780055397 no 1990 0.435566505003813 612 1644229
SGTC_2070 5230947 200 µM -0.162831289802871 0.414368731715535 no 1991 0.435325635670292 657 2835538
SGTC_3315 9136395 68.55 µM -0.163348548207898 0.414145515886718 no 1992 0.435122005621526 629 16876844
SGTC_2278 7948257 134.34 µM -0.164136295704271 0.413805627465639 no 1993 0.434811924714544 604 1247028
SGTC_2593 nobiletin 86.24 µM -0.165031678089163 0.413419376363639 no 1994 0.434459524197015 620 72344 An anti-infammatory.
SGTC_1406 3909-7906 11.9 µM -0.165407678560665 0.413257201794115 no 1995 0.434311555153359 627 X1406
SGTC_733 4069-0007 56.1 µM -0.166403063539455 0.41282794903477 no 1996 0.433919881605695 602 5717425 YNL287W SEC21
SGTC_945 3381-0768 11.3 µM -0.166428800950846 0.412816851337417 no 1997 0.433909755063013 641 1126236 YIL048W NEO1
SGTC_1957 st077035 62.4 µM -0.166501931079195 0.412785318786174 no 1998 0.433880981801336 623 705593
SGTC_2129 girgensonine 121.053 µM -0.166533038628341 0.412771905875054 no 1999 0.43386874255186 632 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.168806824326638 0.411791774793499 no 2000 0.432974295163536 634 4174840
SGTC_3254 9136651 49.47 µM -0.170776745473759 0.410943071109495 no 2001 0.432199657430562 620 16454030
SGTC_338 4055-0136 114 µM -0.171047606250212 0.4108264083091 no 2002 0.432093166382406 611 2900563
SGTC_540 1187-0821 17.3 µM -0.17215369381344 0.410350085861975 no 2003 0.431658350633418 622 847520
SGTC_1223 0764-0573 147 µM -0.172240471181899 0.410312721883702 no 2004 0.431624240946953 614 1609797
SGTC_3347 9188721 44.724 µM -0.172432262897432 0.410230144467905 no 2005 0.431548854951439 634 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_2647 atorvastatin 60.16 µM -0.172854944192629 0.410048169803632 no 2006 0.431382723889189 643 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_2905 7799065 20.05 µM -0.173519629137468 0.409762045827249 no 2007 0.431121500041941 667 1296806
SGTC_901 1112-0062 60.1 µM -0.174357674584296 0.409401364621534 no 2008 0.430792187774223 610 1908457
SGTC_2161 5662504 8.5105 µM -0.17520997680292 0.409034626173271 no 2009 0.43045732262029 609 2859334
SGTC_2019 4016004 108 µM -0.175613603982433 0.408860976565556 no 2010 0.430298757011854 632 45595336
SGTC_2454 5-benzylidenerhodanine 10.36 µM -0.175662362401374 0.408840000793237 no 2011 0.430279602946274 615 1273210
SGTC_3019 9081971 49.47 µM -0.175944654159904 0.408718564588235 no 2012 0.430168711787615 638 16451803
SGTC_99 0109-0120 622.8 µM -0.176826264497539 0.408339370120114 no 2013 0.429822429021429 667 759414
SGTC_697 0508-1955 564 µM -0.177406621086975 0.408089796440908 no 2014 0.429594503466984 637 6243113
SGTC_610 4215-0184 155 µM -0.17782097812198 0.40791163119579 no 2015 0.429431785874861 626 5605015
SGTC_2838 9002687 71.43 µM -0.178390821943065 0.407666640845312 no 2016 0.429208028364361 651 6457060
SGTC_263 alizarin 107.927 µM -0.178908448262814 0.407444131416858 no 2017 0.429004794531649 629 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2780 5215298 71.43 µM -0.179008923796203 0.407400943961865 no 2018 0.42896534734976 673 2834131
SGTC_646 4092-0839 27.3 µM -0.179830580568144 0.407047813052219 no 2019 0.42864278757366 631 877796
SGTC_2699 st077704 54.6 µM -0.180070449451138 0.40694473665321 no 2020 0.428548630646918 636 645852
SGTC_3214 9129694 49.47 µM -0.180455532450638 0.40677927236095 no 2021 0.428397480607497 629 17158655
SGTC_2377 9073351 62.6 µM -0.180464548889249 0.406775398334036 no 2022 0.428393941664913 667 7337946 YHR072W ERG7
SGTC_1206 3978-0017 132 µM -0.18210599292389 0.406070283509904 no 2023 0.427749772850573 666 3873677
SGTC_3352 9151559 45.5865 µM -0.182480195453629 0.405909579943901 no 2024 0.42760294757926 608 17159339
SGTC_140 0062-0056 502.533 µM -0.184273337268808 0.405139724679008 no 2025 0.426899514756203 628 3758964
SGTC_2575 plumbagin 510 nM -0.184736617304254 0.404940882718274 no 2026 0.426717812005451 647 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_443 clozapine 122 µM -0.185027895582887 0.404815877278877 no 2027 0.426603577907554 632 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_1635 st007035 42.4 µM -0.185326547584769 0.404687717406011 no 2028 0.426486458360391 623 3716403
SGTC_3160 9100216 49.47 µM -0.186673542453367 0.404109811719144 no 2029 0.425958300745434 627 17191039
SGTC_1338 1486-1223 76 µM -0.187055553755517 0.403945954164498 no 2030 0.425808537980318 641 3444526
SGTC_3035 9091303 49.47 µM -0.187151874886723 0.403904641436239 no 2031 0.42577077817097 631 25237002
SGTC_1002 4049-0206 172 µM -0.188319104416618 0.403404094807862 no 2032 0.425313255058888 622 4662749
SGTC_1468 k284-1086 134 µM -0.188845115427734 0.403178575549633 no 2033 0.425107105484251 636 15996457
SGTC_3049 9092223 49.47 µM -0.189782008785733 0.402776976500069 no 2034 0.424739977292743 652 8623917
SGTC_1750 st081859 2.357 µM -0.190002821793575 0.402682339990713 no 2035 0.424653459669929 654 5291695
SGTC_3329 9141233 27.5565 µM -0.192523892877587 0.401602259466134 no 2036 0.423665927079426 632 4909101 YNL103W MET4
SGTC_2651 TUB2.036 5 µM -0.192534591620015 0.401597677492166 no 2037 0.423661737275586 625 15992207 YFL037W TUB2
SGTC_1483 3453-0561 55.9 µM -0.194228593793983 0.400872354506584 no 2038 0.422998447282377 637 4546991
SGTC_2489 cantharidin 73.42 µM -0.194721022027189 0.400661574875788 no 2039 0.422805676859473 629 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2753 fluvastatin 17.09 µM -0.194845298985335 0.400608383770774 no 2040 0.422757029193345 644 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2607 solasodine 47.35 µM -0.196235512042438 0.400013492079963 no 2041 0.422212916894572 634 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_979 1426-2828 121 µM -0.197102390304224 0.399642660022658 no 2042 0.421873706464569 645 747872
SGTC_2027 5150920 200 µM -0.198528330452145 0.39903287022694 no 2043 0.421315860678531 647 786715
SGTC_659 k018-0002 107 µM -0.19996773301612 0.398417573167144 no 2044 0.420752908369912 647 6797879 YHR007C ERG11
SGTC_2355 9061122 103.12 µM -0.199983514002168 0.398410828713103 no 2045 0.42074673730053 662 5302957
SGTC_684 1140-0066 328 µM -0.200865260953186 0.398034037300678 no 2046 0.420401965903745 657 6813534
SGTC_726 3448-4391 34.2 µM -0.201146465546897 0.397913891878044 no 2047 0.42029202507715 667 1356692
SGTC_497 capsazepine 133 µM -0.201868396927701 0.397605489097687 no 2048 0.420009804510212 626 2733484 A calcium channel blocker.
SGTC_782 0083-0095 30.5 µM -0.202734605905759 0.397235536649379 no 2049 0.419671236603915 675 3591729 An indicator and reagent.
SGTC_15 0266-0086 27.098 µM -0.203725374264884 0.396812499013216 no 2050 0.41928405611049 633 1712902 YIL048W NEO1
SGTC_2992 9074591 71.4286 µM -0.204300063473451 0.396567174187508 no 2051 0.419059510186671 629 17741321
SGTC_1461 k072-0203 53.8 µM -0.204453394365116 0.396501726811953 no 2052 0.418999604297382 638 5418714
SGTC_2011 4012611 177 µM -0.204686093253937 0.396402407769738 no 2053 0.418908693173401 657 2049887
SGTC_3258 9138477 49.47 µM -0.204819724001685 0.396345375392192 no 2054 0.418856488084862 611 4970355
SGTC_2330 7979373 200 µM -0.204997820463337 0.396269368903892 no 2055 0.418786913942122 634 1863007
SGTC_294 k038-0071 157 µM -0.205068510303795 0.396239201589773 no 2056 0.418759299358358 642 24152826
SGTC_1319 1306-0155 43.7 µM -0.205303420688726 0.396138956635419 no 2057 0.418667535829912 627 3122360
SGTC_971 1315-0384 26.7 µM -0.205683815134897 0.395976642814923 no 2058 0.418518950949812 667 6769120
SGTC_1141 3253-0389 52.6 µM -0.208107890548672 0.394942717719591 no 2059 0.417572363136261 617 5402031
SGTC_654 1124-0271 80.9 µM -0.208139832052197 0.394929098837788 no 2060 0.417559893333892 641 5403748
SGTC_2572 astragaloside iv 100 µM -0.208322788314189 0.394851094348062 no 2061 0.417488469726892 635 45006101 An anti-inflammatory agent.
SGTC_3247 9135149 49.47 µM -0.208746001990502 0.394670670837711 no 2062 0.417323263366893 632 8934436 YOR116C RPO31
SGTC_1143 3454-2408 5.08 µM -0.208753091104405 0.394667648814746 no 2063 0.41732049617338 637 X1143
SGTC_2189 6047310 154.431 µM -0.209285762839757 0.394440593978501 no 2064 0.417112582648319 633 711535
SGTC_24 0417-1663 219 µM -0.211141885596593 0.393649690081903 no 2065 0.416388278458856 670 4329390
SGTC_2226 7298446 200 µM -0.21154653506457 0.393477324878335 no 2066 0.4162304120039 657 3283010
SGTC_2941 9056145 11.23 µM -0.21232069913527 0.393147618775449 no 2067 0.415928423985417 653 2119517
SGTC_1766 st045414 44.774 µM -0.213096309226941 0.392817373672193 no 2068 0.415625921672421 630 253960
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.216035644532569 0.391566543349052 no 2069 0.414479981612223 630 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1198 1612-1005 86.7 µM -0.216266494862862 0.391468352571407 no 2070 0.4143900121412 633 6998509
SGTC_1897 st060201 15 µM -0.216872483466077 0.391210631937505 no 2071 0.414153861134404 636 611878
SGTC_2841 9004761 38.96 µM -0.217983509474274 0.390738248283347 no 2072 0.413720980010334 638 2991039
SGTC_2281 7943571 200 µM -0.218872334096001 0.390360455764223 no 2073 0.413374749074475 653 1244024
SGTC_138 0850-0259 40.9225 µM -0.219764949827457 0.38998115600836 no 2074 0.413027109138227 658 6813004
SGTC_1322 1348-1070 12 µM -0.220012146796245 0.389876132949964 no 2075 0.41293084734999 645 6758089
SGTC_3096 9117468 49.47 µM -0.223213252532388 0.388516853419803 no 2076 0.411684769050415 660 41316311
SGTC_124 0136-0217 7.121 µM -0.224006213654757 0.388180349979791 no 2077 0.411376234145797 662 3976905
SGTC_3272 9137413 49.47 µM -0.225054159063311 0.387735769403816 no 2078 0.4109685709661 682 17614870
SGTC_2851 9015922 71.43 µM -0.22623565823982 0.38723470642866 no 2079 0.410509069101888 635 2996893
SGTC_430 0958-0115 16.4 µM -0.226344050042401 0.387188747851604 no 2080 0.410466920126245 654 6833180
SGTC_3243 9134147 49.47 µM -0.226611848808823 0.387075206836877 no 2081 0.410362788976484 659 24282180
SGTC_2766 oltipraz 83.91 µM -0.227941006308929 0.386511815316526 no 2082 0.409846051650608 653 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_1796 st049173 110.4 µM -0.230309052338809 0.385508662155399 no 2083 0.40892581345943 660 94134
SGTC_679 0422-0091 41.4 µM -0.230695271229944 0.385345124286549 no 2084 0.408775773730009 642 627384 YHR062C RPP1
SGTC_3142 9086498 49.47 µM -0.231225093795357 0.385120813035764 no 2085 0.40856996807092 678 25236367
SGTC_466 geldanamycin 89.2 µM -0.231610154139623 0.384957813953097 no 2086 0.408420410043176 641 5288382 HSP90 inhibitor.
SGTC_181 1447-1644 8.07 µM -0.2319047316148 0.384833130705435 no 2087 0.408306004703962 670 534600
SGTC_120 rhodamine 6G 52.259 µM -0.231955467506634 0.384811657367303 no 2088 0.408286301145204 654 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_96 0929-0093 37.281 µM -0.232084776431213 0.384756930563719 no 2089 0.408236084371757 649 6991579
SGTC_2771 fluoxetine 41.05 µM -0.235333116395732 0.383382907066723 no 2090 0.406975096800042 665 3386 A selective serotonin reuptake inhibitor.
SGTC_812 4251-0442 148 µM -0.237008443459834 0.382674827946754 no 2091 0.406325119964209 678 5723007
SGTC_3014 9081533 49.47 µM -0.237009844366635 0.382674236015417 no 2092 0.406324576561968 687 21367265
SGTC_1876 myriocin 605 nM -0.239274456518477 0.38171771867929 no 2093 0.405446385472969 683 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_3293 9120939 62.045 µM -0.239278400928442 0.381716053284038 no 2094 0.405444856289 693 934087
SGTC_2863 9028737 58.44 µM -0.244775551375645 0.379397206035678 no 2095 0.403315112660401 679 6460917
SGTC_2158 5657123 3.6195 µM -0.244972326622326 0.379314280712489 no 2096 0.403238929378582 722 2858827
SGTC_3084 9116877 49.47 µM -0.245895730788751 0.378925212547974 no 2097 0.402881474362779 656 27241325
SGTC_2972 9093619 59.92 µM -0.246344613629864 0.378736124015554 no 2098 0.40270773855312 643 25236256
SGTC_3296 9122258 64.045 µM -0.247765969643667 0.378137580094269 no 2099 0.402157743181243 675 4730474
SGTC_2568 diosmetin 100 µM -0.248015006418082 0.378032738857133 no 2100 0.402061398018233 645 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2032 5185112 25.99 µM -0.248558841233926 0.377803822717477 no 2101 0.401851024668019 635 5718189
SGTC_3022 9087993 49.47 µM -0.24951714611346 0.377400548345362 no 2102 0.40148038978213 634 17173644
SGTC_1919 st067113 52.3 µM -0.250862212347187 0.376834742365507 no 2103 0.400960320262849 667 1268243
SGTC_2512 diallyl trisulfide 49.23 µM -0.252113813442417 0.376308490222767 no 2104 0.400476546588584 663 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1450 4112-4260 37.6 µM -0.252120761721829 0.37630556936799 no 2105 0.400473861338229 639 1633175
SGTC_608 k048-0125 159 µM -0.25294023834114 0.37596113493483 no 2106 0.400157197272875 675 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1188 1403-0014 4.57 µM -0.252994132776118 0.375938486010089 no 2107 0.400136373557622 659 9614867
SGTC_1425 4048-4433 7.33 µM -0.254160546669964 0.375448409985545 no 2108 0.3996857645793 676 23734946
SGTC_1810 st050138 53 µM -0.254777472964992 0.375189285767947 no 2109 0.399447487600555 696 3444541
SGTC_2829 7992743 58.44 µM -0.25605614280472 0.374652392424021 no 2110 0.398953743109344 668 16462845
SGTC_1716 st033144 30.6155 µM -0.256379663290087 0.374516589725098 no 2111 0.398828844773655 688 674617
SGTC_3177 9107506 49.47 µM -0.256767435380411 0.374353836935465 no 2112 0.398679155110476 666 8897194
SGTC_1756 st041558 35.5 µM -0.257253581560382 0.37414982694074 no 2113 0.398491511660887 696 3955792
SGTC_3043 9092303 49.47 µM -0.258207438177946 0.373749645913733 no 2114 0.39812340884592 664 25236084
SGTC_1323 1348-1351 11.2 µM -0.259407174173979 0.373246501886694 no 2115 0.397660547468591 655 6989654
SGTC_1127 asiatic acid 681.4 nM -0.261018096108392 0.372571255073376 no 2116 0.397039276094121 655 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_1989 st071868 50.2 µM -0.261404397636499 0.372409387976796 no 2117 0.39689033304255 677 16414057
SGTC_1680 diphenhydramine 100 µM -0.261670388234116 0.372297946363521 no 2118 0.39678778601272 663 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_873 0591-4978 488 µM -0.261698149289381 0.372286315979082 no 2119 0.396777083738239 668 3305145
SGTC_378 3970-0959 8.33 µM -0.262423257401087 0.371982576086449 no 2120 0.396497571995914 697 6615653
SGTC_1959 st077091 55.8 µM -0.262767817837531 0.371838271376313 no 2121 0.396364770863873 663 821356 YKL052C ASK1
SGTC_499 genistein 192 µM -0.263118154880722 0.371691565834804 no 2122 0.396229755628503 665 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2217 6934799 96.0675 µM -0.264474440058338 0.37112378990573 no 2123 0.395707178855738 673 675606
SGTC_400 oxethazaine 37.5 µM -0.264855392484672 0.3709643637901 no 2124 0.39556043153455 685 4621 A local anesthetic.
SGTC_1791 st048313 56.1 µM -0.265867869626549 0.370540756394715 no 2125 0.395170485540682 630 1204976
SGTC_3238 9133470 49.47 µM -0.266532705282712 0.370262683031257 no 2126 0.394914487438861 669 3534688
SGTC_1156 4092-0367 4.88 µM -0.268377810025746 0.369491307273687 no 2127 0.394204259113166 651 1357585
SGTC_3263 9137018 49.47 µM -0.268474781070585 0.369450781461799 no 2128 0.394166942166582 655 43844957
SGTC_2696 st077691 74.316 µM -0.268478281895417 0.369449318436022 no 2129 0.394165594977514 697 757133
SGTC_2900 5328528 85.29 µM -0.269316017718308 0.369099275595882 no 2130 0.393843253521946 641 795359
SGTC_896 0964-0007 44.5 µM -0.270436462114226 0.368631274371952 no 2131 0.393412246021007 657 6756758
SGTC_1455 4262-0120 131 µM -0.270582159883116 0.368570431802438 no 2132 0.393356209243165 656 1529587
SGTC_1864 st057645 30.4 µM -0.272092500904815 0.367939916239922 no 2133 0.392775447755724 669 688666
SGTC_1432 4049-0298 68.4 µM -0.272694260299494 0.367688801318101 no 2134 0.392544123584654 680 741646
SGTC_1891 st059073 26.2 µM -0.273055631464626 0.367538027865066 no 2135 0.392405226024778 683 688754
SGTC_3327 9140648 26.9345 µM -0.273254343109188 0.367455128894474 no 2136 0.392328854539794 679 8029710
SGTC_385 1494-0393 12.4 µM -0.273482596199919 0.367359913379236 no 2137 0.392241134413345 688 3090647
SGTC_1495 4469-0029 237 µM -0.273639543928749 0.367294447545113 no 2138 0.392180820883817 679 793680
SGTC_2467 5474540 200 µM -0.273844792589825 0.367208840309389 no 2139 0.392101949671154 654 5413519
SGTC_3183 9108214 49.47 µM -0.275737026619743 0.366419919203167 no 2140 0.391375027262806 679 4974831
SGTC_1422 4031-0024 15.5 µM -0.275969824907672 0.366322898507443 no 2141 0.39128562139906 678 782427
SGTC_95 0471-0001 561.058 µM -0.276044036295359 0.366291972066751 no 2142 0.391257121824343 650 4015405
SGTC_312 4092-0653 6.84 µM -0.276374972794671 0.366154070005242 no 2143 0.39113003860664 664 1148278
SGTC_2736 butenafine 14.65 µM -0.27707124272156 0.365863989057846 no 2144 0.390862701343237 677 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.277707922461739 0.36559880175919 no 2145 0.390618289245109 648 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1219 1469-0211 33.1 µM -0.278264211579243 0.3653671510077 no 2146 0.390404773306716 697 6822282
SGTC_265 mycophenolic acid 32.932 µM -0.27937556237352 0.364904507760378 no 2147 0.389978311573163 689 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_3053 9095903 49.47 µM -0.280778395866972 0.364320804229602 no 2148 0.389440187459425 699 17174018
SGTC_1697 st025554 27.742 µM -0.281374830896547 0.364072729408774 no 2149 0.389211460325529 652 1269519
SGTC_94 0334-0113 514.748 µM -0.282098578624654 0.363771777988489 no 2150 0.388933961541549 662 6795178
SGTC_2619 obliquin 87.91 µM -0.284031976058543 0.362968238102854 no 2151 0.388192937988203 664 6708593 A bioactive alkalod. YER133W GLC7
SGTC_3271 9137798 49.47 µM -0.288033237402378 0.361307191090824 no 2152 0.386660648253049 653 6498326
SGTC_1944 st076371 56.9 µM -0.288662674007639 0.361046129437937 no 2153 0.386419764534406 655 24208455
SGTC_560 2332-1943 155 µM -0.292384055702058 0.35950399566764 no 2154 0.384996498794009 674 21177716
SGTC_1305 1181-0477 144 µM -0.292402167382843 0.359496495788715 no 2155 0.384989575638401 669 6252086
SGTC_1157 4092-0394 27.6 µM -0.29251387711932 0.359450239020048 no 2156 0.384946875614178 665 3659885
SGTC_1374 2889-5571 141 µM -0.293209637683064 0.359162184863794 no 2157 0.384680958933969 658 2853281
SGTC_1400 3771-8998 51.5 µM -0.294438150702084 0.358653759614745 no 2158 0.384211559086561 657 670767
SGTC_2521 angolensin 13.4 µM -0.294761347303348 0.358520044913864 no 2159 0.384088097783989 663 821428 A flavenoid.
SGTC_1676 st018489 23.4 µM -0.300511385747036 0.356144019834572 no 2160 0.381893556486679 678 3696235
SGTC_1678 st019265 80.2 µM -0.300764676331591 0.356039482895996 no 2161 0.381796973052595 706 5367020
SGTC_1367 1812-0510 76.9 µM -0.300767164920599 0.356038455870523 no 2162 0.381796024153407 672 1142582 YDR527W RBA50
SGTC_109 0132-0036 33.701 µM -0.301643883920296 0.35567670435273 no 2163 0.381461775367429 652 67274 A color developer.
SGTC_306 1672-3436 11.6 µM -0.302921999518546 0.35514956156976 no 2164 0.380974652688002 710 6797378
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.303073039662364 0.355087285240754 no 2165 0.380917099854349 683 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_810 3825-7150 143 µM -0.303114158068701 0.355070332117556 no 2166 0.380901432417602 663 22330411 YGL099W LSG1
SGTC_580 1123-0028 41 µM -0.303653086642374 0.354848158345102 no 2167 0.380696101339732 689 1677248 YPR107C YTH1
SGTC_3091 9116372 49.47 µM -0.308318971857158 0.352926713708279 no 2168 0.37891981565079 683 17169793
SGTC_594 1487-1584 10.8 µM -0.310276783131913 0.352121585524025 no 2169 0.378175242452844 712 5013332
SGTC_976 1348-1067 47.6 µM -0.311282389828991 0.351708298183337 no 2170 0.377792976808838 661 5310671 YGL099W LSG1
SGTC_3105 9121040 49.47 µM -0.311839111304264 0.351479570383409 no 2171 0.37758139928486 664 41448907
SGTC_2013 4024628 200 µM -0.311871050607179 0.351466449820731 no 2172 0.377569262122823 714 5230760
SGTC_2522 biochanin a 4.94 µM -0.311941691047984 0.351437431583941 no 2173 0.377542418682819 701 5280373 A possible chelator.
SGTC_2970 9090938 41.86 µM -0.312123744855043 0.351362650078378 no 2174 0.377473240776169 675 17217104
SGTC_129 0088-0017 176.636 µM -0.312174757667084 0.351341696783867 no 2175 0.377453857324277 711 182446
SGTC_199 4063-0024 41.6 µM -0.31292196532856 0.351034836235465 no 2176 0.37716997456113 696 306215
SGTC_2259 7964009 200 µM -0.313338767956447 0.350863707417188 no 2177 0.377011649709966 681 313134
SGTC_422 cantharidin 155 µM -0.313560928665674 0.350772506097793 no 2178 0.376927269145466 664 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1973 st070275 50.2 µM -0.314718103559915 0.350297602293329 no 2179 0.376487848793582 671 17118334
SGTC_266 formosanin C 406 nM -0.314986218141874 0.350187601604912 no 2180 0.376386058988123 684 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_808 0711-0032 135 µM -0.315353682794465 0.350036860491087 no 2181 0.376246564855059 716 4252555
SGTC_2044 5102272 200 µM -0.317577581481551 0.349125079160743 no 2182 0.375402690906693 673 592666
SGTC_2470 5664817 21.68 µM -0.317705701061738 0.349072577582291 no 2183 0.375354093148212 681 2859561
SGTC_2754 granisetron 64.02 µM -0.318128081214524 0.348899512678913 no 2184 0.375193891771262 722 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_1180 1193-0155 285 µM -0.320233424636725 0.348037344338956 no 2185 0.374395693518888 708 2921347
SGTC_508 roscovitine 141 µM -0.320412988509223 0.347963846623877 no 2186 0.374327640372289 690 160355 A CDKinase inhibitor.
SGTC_2134 5324836 1.464 µM -0.322069849552945 0.347285942704363 no 2187 0.373699889433625 677 699272
SGTC_1058 3448-5425 97.3 µM -0.322097616626645 0.347274585973275 no 2188 0.373689371903291 690 7279705
SGTC_1137 ixabepilone 100 µM -0.322120762566842 0.347265119390241 no 2189 0.373680604824169 653 154225 A novel microtubule stabilizer.
SGTC_1958 st076513 41.9 µM -0.322249854181282 0.347212323261851 no 2190 0.373631709482896 706 732122 YGL099W LSG1
SGTC_2246 7293507 91.5585 µM -0.322460129850961 0.347126330676294 no 2191 0.373552068845922 717 887656
SGTC_130 0136-0219 337.655 µM -0.322725427952995 0.347017847805366 no 2192 0.373451596500395 734 234244
SGTC_1928 4'-methoxychalcone 40.3 µM -0.323635502484487 0.346645805146874 no 2193 0.373107003115225 722 641818
SGTC_2466 5983409 37.09 µM -0.323679311187259 0.346627899674672 no 2194 0.373090417812929 693 2879657
SGTC_3325 9138760 55.175 µM -0.324093198625773 0.34645875271161 no 2195 0.372933737993461 681 43844959
SGTC_3193 9111931 49.47 µM -0.324553463916876 0.346270688060537 no 2196 0.37275952621263 692 17087244
SGTC_484 loperamide 105 µM -0.325811225559521 0.34575695936668 no 2197 0.372283592504814 662 3955 An opioid-receptor agonist.
SGTC_804 1595-0054 20.9 µM -0.326614080407111 0.345429184254538 no 2198 0.371979896252991 714 761523 Stimulates phospholipase C.
SGTC_857 0438-0306 1.35 µM -0.328181356305878 0.344789659167758 no 2199 0.371387271717493 668 4686136
SGTC_2782 7736369 71.43 µM -0.328462101395805 0.344675148221272 no 2200 0.371281147423778 691 2950836 YOL077C BRX1
SGTC_3191 9110352 49.47 µM -0.328568159220269 0.344631892817078 no 2201 0.371241059111392 697 17122424
SGTC_2898 9056270 58.44 µM -0.32902941413532 0.344443794849656 no 2202 0.371066727728199 658 19154699
SGTC_1069 diphenylcyclopropenone 8.49 µM -0.329903280707021 0.344087540940516 no 2203 0.370736522256757 737 65057 A dermal irritant. YDR527W RBA50
SGTC_1669 st015249 58.4 µM -0.330190850888016 0.343970335887643 no 2204 0.370627879735698 696 722793
SGTC_3077 9117319 49.47 µM -0.330970337050156 0.343652715925039 no 2205 0.370333445810341 706 17154678
SGTC_3301 9125354 19.7965 µM -0.331226941144423 0.343548180684052 no 2206 0.370236535809848 666 41905162
SGTC_1138 3761-0006 1.03 µM -0.33178752923607 0.34331985023119 no 2207 0.370024850808292 688 12061087
SGTC_657 3534-0529 86.7 µM -0.331968096355316 0.3432463164725 no 2208 0.369956674809113 705 1049549
SGTC_522 1273-0010 11.6 µM -0.33259679324427 0.342990333644464 no 2209 0.369719332156743 661 5705015
SGTC_1082 camptothecin 424.86 nM -0.335331021089698 0.341877893466243 no 2210 0.368687697781242 661 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1825 st052143 62.6 µM -0.335477433909802 0.34181836296469 no 2211 0.368632482285448 715 674173
SGTC_1351 1496-0003 46.5 µM -0.336438380898659 0.341427745840201 no 2212 0.368270155393835 691 3891978
SGTC_1060 3448-7350 82 µM -0.338679388137414 0.340517454986324 no 2213 0.367425634915459 718 570178
SGTC_813 k007-0158 173 µM -0.340927844848785 0.339605070912718 no 2214 0.366578951049402 685 6523916
SGTC_2784 7567673 72.73 µM -0.341147620576934 0.339515940098709 no 2215 0.36649622655795 701 3471247
SGTC_764 1951-2361 146 µM -0.341620178635169 0.339324322931131 no 2216 0.366318374763313 707 5438930
SGTC_732 3970-1727 52.7 µM -0.343339138868334 0.338627653895365 no 2217 0.365671669872465 722 1275699
SGTC_2485 5633444 17.78 µM -0.343496341768212 0.338563969400726 no 2218 0.365612546227962 676 5724239
SGTC_2192 5915882 198.485 µM -0.344892109185127 0.33799873243797 no 2219 0.365087741511128 697 2876149
SGTC_2671 danthron 100 µM -0.345276450738909 0.33784315160356 no 2220 0.364943274454252 693 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_3169 9102970 49.47 µM -0.345444686745017 0.337775058657328 no 2221 0.364880043605427 664 17027839
SGTC_652 0437-0092 114 µM -0.345797176897737 0.337632406695613 no 2222 0.364747573469035 686 3091274
SGTC_1936 st074407 74.3 µM -0.346379398220822 0.33739683414361 no 2223 0.364528802898264 678 809813
SGTC_352 k048-0007 5.11 µM -0.346524468156299 0.337338147314371 no 2224 0.364474299506453 735 6811911
SGTC_1668 st014914 51.6 µM -0.346612008324672 0.337302735585622 no 2225 0.364441411618266 687 2839556
SGTC_1976 st070609 63.5 µM -0.347044590666816 0.337127768638311 no 2226 0.364278909795296 676 682556
SGTC_2705 st078069 42.8 µM -0.347612039687325 0.336898305466478 no 2227 0.364065781589592 718 1530061
SGTC_51 1013-0126 23.419 µM -0.348070623497846 0.336712909187556 no 2228 0.363893572783238 731 1627850
SGTC_1644 st010134 20.9 µM -0.349251169600264 0.336235820597397 no 2229 0.363450377002916 729 3818134
SGTC_182 3448-4371 550.524 µM -0.349849107435448 0.335994279294902 no 2230 0.363225971297607 665 3491403
SGTC_2802 7925815 54.55 µM -0.350642233014948 0.335673994981663 no 2231 0.362928384184834 698 1262923
SGTC_1686 st019653 115.5 µM -0.350820889832703 0.335601865268216 no 2232 0.36286136211954 727 97252
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM -0.35237286774713 0.334975535156383 no 2233 0.36227932357894 706 91467 include heat shock
SGTC_1560 lithocholic acid 53.1 µM -0.352427066774329 0.334953670390359 no 2234 0.362259003051925 688 9903 A bile acid which acts as a detergent.
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.35491528248987 0.333950487214522 no 2235 0.361326529541838 723 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_2403 6032726 181.2 µM -0.356226018171662 0.333422509260813 no 2236 0.360835654298662 702 2881040
SGTC_1559 coumarin 343 70.1 µM -0.356511576692264 0.333307527041454 no 2237 0.360728741975607 723 108770 A hepatotoxic, DNA x-linker.
SGTC_3288 9119690 36.221 µM -0.35781962389373 0.332781032639477 no 2238 0.360239151934705 724 17595618 YKL019W RAM2
SGTC_2219 9098279 200 µM -0.358468931173337 0.332519806112822 no 2239 0.359996207231009 706 902349
SGTC_929 2805-0021 398 µM -0.358741771212509 0.332410062531314 no 2240 0.359894138313039 742 3098024
SGTC_86 0417-1630 471.922 µM -0.360420361332495 0.331735204926265 no 2241 0.359266401118575 701 3634867
SGTC_2469 5655019 90.81 µM -0.36063970742036 0.331647059653592 no 2242 0.359184400949879 721 2788239
SGTC_1567 st069303 68.4 µM -0.360717754761625 0.331615698204977 no 2243 0.359155225357715 715 5581319
SGTC_2580 diallyl disulphide 81.36 µM -0.36466526088615 0.330031031343063 no 2244 0.357680646606451 656 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1727 st034309 9.9045 µM -0.364827654826042 0.329965905760235 no 2245 0.357620030139521 731 870305
SGTC_1365 1672-3266 55.4 µM -0.367165260068353 0.329029017055304 no 2246 0.356747875410438 726 6415873
SGTC_2558 carylophyllene oxide 100 µM -0.367505680850104 0.32889266919436 no 2247 0.35662092757792 728 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_1737 st035557 69.7 µM -0.367742972678307 0.328797640773082 no 2248 0.356532447415961 715 5716916
SGTC_2088 5278280 127.392 µM -0.368111262898499 0.328650173256198 no 2249 0.356395136536384 705 791502
SGTC_2822 7994718 71.43 µM -0.368734621213338 0.328400634430424 no 2250 0.356162770187009 722 1018011
SGTC_916 4466-0038 42 nM -0.369309025118791 0.328170760467493 no 2251 0.355948699618761 721 5722064 YGL116W CDC20
SGTC_1843 st055809 45.5 µM -0.369667544003654 0.32802731572646 no 2252 0.355815108737859 712 16413835
SGTC_3130 9127414 49.47 µM -0.370040126257025 0.327878271052641 no 2253 0.355676296340812 711 1494646
SGTC_450 aminopyrene 156 nM -0.370301371650664 0.327773780987237 no 2254 0.355578975958747 727 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1641 st009299 47.1 µM -0.370796002523814 0.327575980896404 no 2255 0.355394739494036 690 4046054
SGTC_3351 9150312 21.596 µM -0.371433804055625 0.327320999090209 no 2256 0.355157225754438 706 4904905
SGTC_3285 9112818 20.8695 µM -0.37195193977773 0.327113916855207 no 2257 0.354964316309542 716 17017947 YPR165W RHO1
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.372507174408115 0.326892066440188 no 2258 0.354757635666232 699 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1135 dihydrocapsaicin 536.708 nM -0.373135037466528 0.326641270197474 no 2259 0.354523971301496 724 107982 A Capsaicinoid.
SGTC_977 1348-1378 135 µM -0.37446627905178 0.326109772685897 no 2260 0.354028720033588 703 X977
SGTC_1961 st076550 68.7 µM -0.375531152906426 0.325684876429387 no 2261 0.35363274109182 708 1579337
SGTC_2388 9080168 200 µM -0.375575345355766 0.325667248049454 no 2262 0.353616311315952 707 15943073
SGTC_2666 tannic acid 100 µM -0.378357401745867 0.324558271190176 no 2263 0.352582554325399 720 16134267 A thiamine antagonist.
SGTC_1328 1441-0025 69.2 µM -0.378659427231508 0.324437971816718 no 2264 0.352470392964476 710 4562601
SGTC_2601 securinine 100 µM -0.379806615449212 0.323981203811309 no 2265 0.352044485638937 709 442872 A GABA receptor antagonist.
SGTC_3066 9117245 49.47 µM -0.380401959770734 0.323744264035088 no 2266 0.35182353004493 719 17176980
SGTC_644 1498-1197 63.3 µM -0.380848044842251 0.323566774417944 no 2267 0.351658003191065 711 6741615
SGTC_3318 9139014 38.6185 µM -0.381029269729684 0.323494679597176 no 2268 0.351590764888261 736 16643984
SGTC_2943 9068529 45.32 µM -0.381728466946546 0.323216587320102 no 2269 0.351331391319574 706 3270634
SGTC_2877 9040724 71.43 µM -0.381854692968381 0.323166393861407 no 2270 0.351284574001208 712 6463895
SGTC_1739 st037196 92.5 µM -0.382310249446124 0.322985269759892 no 2271 0.351115626562721 720 612214
SGTC_1363 1636-0063 10.4 µM -0.382473168031254 0.322920505360077 no 2272 0.351055213801888 715 6072185
SGTC_882 0843-0131 351 µM -0.383173109245933 0.322642321522931 no 2273 0.350795707490378 698 5425421
SGTC_469 w7 172 µM -0.383618833248247 0.322465225194428 no 2274 0.350630489599102 695 45115570 A P450 inhibitor.
SGTC_22 0964-0034 14.468 µM -0.383649062729023 0.322453215789174 no 2275 0.350619285366738 727 138402
SGTC_3000 9075062 71.4286 µM -0.384512191042045 0.322110395029503 no 2276 0.350299430983796 692 17057871
SGTC_2848 9016370 25.97 µM -0.384995174252339 0.321918627821856 no 2277 0.350120495439706 688 7894410
SGTC_350 k064-0020 19.8 µM -0.38522024353688 0.321829280850047 no 2278 0.350037123168264 718 2790705
SGTC_3308 9128332 17.569 µM -0.385762119575231 0.3216142116489 no 2279 0.349836426030466 711 17332805 YDL196W YDL196W
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.387271496714215 0.321015459056566 no 2280 0.349277612344643 707 368090
SGTC_1840 st055363 71 µM -0.387439342446979 0.320948905288588 no 2281 0.349215491309892 718 676033
SGTC_3125 9127534 49.47 µM -0.388721185922881 0.320440821788827 no 2282 0.348741204226621 721 1639235
SGTC_2510 benzyl isothiocyanate 8.31 µM -0.389223945457449 0.320241635082602 no 2283 0.348555245709478 708 2346 DNA damaging agent; causes G2/M arrest.
SGTC_1220 1838-0075 193 µM -0.389888031116103 0.319978612473838 no 2284 0.348309672363961 708 5529645
SGTC_353 1988-1175 58.3 µM -0.391245515412568 0.319441238916886 no 2285 0.347807883880458 735 2788357
SGTC_1878 temozolomide 1 mM -0.392706157619878 0.318863452536637 no 2286 0.347268261095352 723 5394 DNA alkylating agent.
SGTC_442 cape 100 µM -0.392828315350182 0.318815150508431 no 2287 0.347223144890276 714 5281787
SGTC_2435 5706476 10.6 µM -0.393208585704013 0.318664808632774 no 2288 0.347082714465658 698 5725375
SGTC_440 fluspirilene 35.1 µM -0.394517633397652 0.318147498092778 no 2289 0.346599455566881 725 3396 An atypical antipsychotic.
SGTC_2788 5282734 71.43 µM -0.396439071186383 0.317388825012072 no 2290 0.345890573761509 754 743706
SGTC_534 k292-0788 63.4 µM -0.397418660218054 0.317002332464508 no 2291 0.345529378645757 736 4146317
SGTC_1622 st003707 19.4 µM -0.398788014461578 0.316462394296694 no 2292 0.345024704573191 721 10140899
SGTC_1463 k081-0032 34.1 µM -0.398938262232417 0.316403175185605 no 2293 0.344969347673813 723 977755
SGTC_2713 st079149 53.4 µM -0.399028740957279 0.31636751589801 no 2294 0.34493601352745 697 3103253
SGTC_287 k060-0039 29.6 µM -0.39943819147665 0.316206165457376 no 2295 0.344785178931583 711 5861974
SGTC_2520 obtusaquinone 4.71 µM -0.40067283819761 0.315719845361884 no 2296 0.344330505531948 712 5967872
SGTC_2390 9097792 176.6 µM -0.404317332676339 0.314286162781216 no 2297 0.342989690686187 711 4497149
SGTC_3167 9103034 49.47 µM -0.404658828636508 0.314151967041906 no 2298 0.342864154756702 707 5127859
SGTC_211 3455-0679 143.504 µM -0.404666769549672 0.314148846838297 no 2299 0.342861235836504 714 748649
SGTC_194 1486-1323 56.904 µM -0.405555356739703 0.313799780394787 no 2300 0.342534668316397 716 5178754
SGTC_475 α-linolenic acid 10 µM -0.405679840046735 0.313750892531153 no 2301 0.342488928449662 723 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1098 clofazimine 15.1 µM -0.406048356799536 0.313606185497056 no 2302 0.342353535024372 712 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_1491 4138-0063 26.5 µM -0.406114920359664 0.313580050759101 no 2303 0.342329081665086 731 23883227
SGTC_3309 9129340 25.759 µM -0.407391167560118 0.313079141067672 no 2304 0.34186035651315 700 17158987
SGTC_207 4185-0010 4.486 µM -0.408067868545012 0.31281368493066 no 2305 0.341611924487467 707 3761753
SGTC_3092 9117248 49.47 µM -0.408606908591783 0.312602299828576 no 2306 0.341414079939377 719 17141857
SGTC_1777 st045864 34.765 µM -0.410079021470854 0.312025323410777 no 2307 0.340873990615417 733 4691462
SGTC_3124 9127567 49.47 µM -0.410263566875831 0.311953025604726 no 2308 0.340806307499651 737 17592030
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -0.410762526623184 0.311757588604959 no 2309 0.340623336731488 718 442882
SGTC_495 decylubiquinone 155 µM -0.410812561118413 0.311737993571147 no 2310 0.34060499092653 751 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_3133 9127736 49.47 µM -0.414080969143714 0.310459142042676 no 2311 0.33940740481837 724 27243420
SGTC_1848 st056003 16.4 µM -0.414390331807529 0.31033821396007 no 2312 0.339294134163078 701 146492
SGTC_756 0508-1999 28.3 µM -0.41468282048652 0.310223900674425 no 2313 0.339187055135325 721 6753853
SGTC_2244 6635614 200 µM -0.414863212452853 0.310153407262337 no 2314 0.339121020775353 694 836499
SGTC_3209 9113616 49.47 µM -0.415129996712165 0.310049166334947 no 2315 0.339023370674741 752 16649353
SGTC_543 3844-1095 191 µM -0.415542527299796 0.309888007827359 no 2316 0.338872394851876 739 4230703
SGTC_3235 9132602 49.47 µM -0.416231569779648 0.309618909112204 no 2317 0.33862028035038 731 4912240
SGTC_411 enrofloxacin 100 µM -0.416698453383016 0.309436630319164 no 2318 0.338449492885226 725 71188 A bacterial gyrase inhibitor.
SGTC_3078 9116413 49.47 µM -0.418876141952501 0.3085870458241 no 2319 0.337653327054111 711 17177322
SGTC_2090 5301565 104.445 µM -0.421227225687436 0.307670963532196 no 2320 0.336794582730707 730 2056344
SGTC_2709 st078560 56 µM -0.421684632180364 0.307492877513393 no 2321 0.336627611523371 746 17250903
SGTC_3221 9128209 49.47 µM -0.425237104867538 0.306111309603202 no 2322 0.335331918928749 736 16460723
SGTC_795 0685-0265 78 µM -0.425403800838891 0.306046548490298 no 2323 0.33527116788006 717 302754
SGTC_1456 k015-0012 13 µM -0.426739629649907 0.305527800237401 no 2324 0.334784491169919 730 2989616
SGTC_1714 st033236 13.627 µM -0.427959276102834 0.305054510259318 no 2325 0.334340384872783 744 2916566
SGTC_2448 5185112 27.17 µM -0.429719968650985 0.304371839495742 no 2326 0.33369967793667 702 5718189
SGTC_2584 androsterone 48.74 µM -0.431071767904596 0.303848170354577 no 2327 0.333208093918388 734 2754130 A steroid.
SGTC_3068 9116768 49.47 µM -0.431243625303795 0.303781623876518 no 2328 0.333145618195678 761 41904888
SGTC_1167 k781-0610 148 µM -0.431556662524281 0.303660426579769 no 2329 0.33303183094074 728 4525169
SGTC_197 4544-0043 41.561 µM -0.432159925909369 0.303426924546033 no 2330 0.332812591481452 736 896523
SGTC_2475 5812728 15.03 µM -0.433415753292871 0.302941095458241 no 2331 0.332356379003959 730 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_1964 st076914 61 µM -0.434286024658674 0.302604626857231 no 2332 0.33204037552529 746 24208661
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -0.436282076947574 0.301833536616878 no 2333 0.331316042053187 744 688669
SGTC_405 ebelactone b 50 µM -0.436379398393493 0.301795963186084 no 2334 0.331280741854751 733 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2839 9003951 25.97 µM -0.43780093023775 0.301247384306496 no 2335 0.330765298287538 747 2990634
SGTC_2824 7998404 51.95 µM -0.437830595562041 0.301235941039968 no 2336 0.330754545134934 753 837851
SGTC_331 k048-0133 24.5 µM -0.438154929159644 0.301110843575568 no 2337 0.330636989084873 717 6813582
SGTC_1130 3454-2858 15.9 µM -0.438654141087761 0.300918340224926 no 2338 0.330456080309377 782 715628 YIL048W NEO1
SGTC_516 3992-2719 87.3 µM -0.439496061548973 0.300593809290095 no 2339 0.330151067578499 712 5350887 YDR037W KRS1
SGTC_3099 9120367 49.47 µM -0.440755164829365 0.300108764053411 no 2340 0.329695127588401 742 24824940
SGTC_414 piperonyl butoxide 100 µM -0.441429965602092 0.299848955865068 no 2341 0.32945087628634 738 5794 A potent inhibitor of cytochrome P450.
SGTC_1285 0929-0069 65.5 µM -0.442627443527751 0.299388160173304 no 2342 0.329017615585919 725 1206237
SGTC_1826 st055655 41.6 µM -0.442706709026981 0.29935766973456 no 2343 0.328988944551372 720 676168
SGTC_1001 4048-4355 44.4 µM -0.444729682097736 0.298579985646291 no 2344 0.328257558132512 752 21824233
SGTC_893 0958-0369 48.9 µM -0.445491757046534 0.298287262438157 no 2345 0.32798220770181 765 6819948
SGTC_1324 1418-0026 34.4 µM -0.445827463806523 0.298158354440015 no 2346 0.327860940879654 743 1372513
SGTC_1342 1486-1464 234 µM -0.447428233775876 0.297544024268548 no 2347 0.327282947053636 746 3253938
SGTC_1474 0330-0125 5.35 µM -0.448159479000947 0.297263585472917 no 2348 0.327019052224634 745 X1474
SGTC_1274 0865-0114 173 µM -0.448323767655913 0.297200595990263 no 2349 0.326959774940758 719 870624
SGTC_3206 9114350 49.47 µM -0.448437557822704 0.297156971577144 no 2350 0.326918720665947 746 17087243
SGTC_2796 7949634 45.45 µM -0.45271206589741 0.295520352943148 no 2351 0.325378045014328 718 2971588
SGTC_1990 st072050 59.8 µM -0.45412903389537 0.294978742104171 no 2352 0.324867978591602 723 17233948
SGTC_3010 9080089 71.4286 µM -0.455045493816397 0.294628685318981 no 2353 0.32453825490689 748 17027233
SGTC_1273 0849-0096 14.1 µM -0.45588784989121 0.294307102824378 no 2354 0.324235313528743 760 5286025
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.455921441035958 0.294294282245648 no 2355 0.324223235361932 741 5024745
SGTC_2951 9072950 58.06 µM -0.457507202161799 0.293689345774409 no 2356 0.323653263397322 758 16488155
SGTC_2756 carbadox 75.1 µM -0.457852258858026 0.293557789757621 no 2357 0.323529293988089 741 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_1572 epiandrosterone 68.9 µM -0.458121658505863 0.293455097654213 no 2358 0.323432519694782 744 441302 A steroid.
SGTC_479 n-linoleoylglycine 10 µM -0.459933415982005 0.292764908828435 no 2359 0.322782006973887 764 6433346 An anti-infammatory.
SGTC_793 0488-0545 106 µM -0.460031402375516 0.292727602416859 no 2360 0.322746840324059 734 292548
SGTC_1282 0886-0010 32.4 µM -0.460497362544876 0.292550227373086 no 2361 0.322579632086727 738 2836211 YNL267W PIK1
SGTC_1007 4101-0031 70 µM -0.460515648594184 0.292543267520308 no 2362 0.322573070930889 755 1146276
SGTC_1178 0988-0033 191 µM -0.462140253083164 0.291925234171541 no 2363 0.321990372771805 724 5392207
SGTC_118 0083-0097 135.343 µM -0.463263727180105 0.291498197211763 no 2364 0.321587671149949 758 5207356
SGTC_1898 st060199 18.6 µM -0.463537798882196 0.291394065695018 no 2365 0.321489463797047 723 688866
SGTC_1084 voriconazole 435 nM -0.463642563631502 0.29135426568881 no 2366 0.321451927030568 774 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_3199 9111318 49.47 µM -0.46387068178901 0.291267612642821 no 2367 0.321370199567394 735 8548020
SGTC_1092 toremifene 6.32 µM -0.463990706375482 0.29122202489026 no 2368 0.321327202056367 777 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1752 st044819 83.042 µM -0.464160674524233 0.291157473267167 no 2369 0.321266316900327 728 441209 YML126C ERG13
SGTC_666 0272-0154 136 µM -0.465065575915462 0.290813916383368 no 2370 0.320942248456528 735 6870312
SGTC_881 0833-0569 170 µM -0.465496593826607 0.290650341822711 no 2371 0.320787937793442 716 5418700
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM -0.466187029348926 0.290388406040852 no 2372 0.320540816385802 771 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2183 6420625 130.508 µM -0.467069203354945 0.290053889884943 no 2373 0.320225183474815 728 2897619
SGTC_2036 5160441 105 µM -0.467130797802875 0.290030540313149 no 2374 0.32020315046011 755 134534 YIL048W NEO1
SGTC_1612 st002233 45.4 µM -0.4683703295533 0.289560839002789 no 2375 0.319759891088122 738 1035021
SGTC_715 0868-0130 184 µM -0.470197944768131 0.288868944875533 no 2376 0.319106801188003 744 2876258
SGTC_196 k015-0023 18.111 µM -0.471115370216118 0.288521921760657 no 2377 0.318779174794199 732 5211998
SGTC_511 blebbistatin 171 µM -0.474025623139665 0.287422398537965 no 2378 0.317740817698662 752 3476986 A myosin inhibitor.
SGTC_2432 5630864 12.22 µM -0.475371647495637 0.286914527983986 no 2379 0.317261049716644 768 5714970
SGTC_1613 st002381 52.1 µM -0.475872397151743 0.286725697919738 no 2380 0.317082644119739 739 551167
SGTC_2135 5326629 150.42 µM -0.475939306264528 0.286700471307858 no 2381 0.317058809158804 734 5020077
SGTC_2733 amorolfine 100 µM -0.476158207845688 0.28661794662719 no 2382 0.316980835389168 762 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_2343 7990716 14.84 µM -0.477152019350668 0.286243426955961 no 2383 0.316626937316205 760 6456862
SGTC_3239 9133757 49.47 µM -0.477408767761123 0.286146708638885 no 2384 0.316535536003971 767 17036923
SGTC_571 k831-0106 44.2 µM -0.478058083387284 0.285902177729133 no 2385 0.316304432480041 778 4783639
SGTC_2853 9015042 58.44 µM -0.478435034732827 0.285760264232385 no 2386 0.316170301377502 731 6457456
SGTC_1131 3454-3128 32.3 µM -0.478741544395103 0.285644895110614 no 2387 0.316061253463051 715 710982
SGTC_2368 9071271 200 µM -0.479044976824388 0.285530706083142 no 2388 0.315953316105761 766 27209959
SGTC_615 k087-0205 167 µM -0.479233259270558 0.285459861730651 no 2389 0.315886347929386 755 9642773
SGTC_2897 9048598 12.99 µM -0.479517633249687 0.285352877234569 no 2390 0.315785213435385 741 6467404
SGTC_1857 st056007 79.3 µM -0.480365238238608 0.285034112622482 no 2391 0.315483853826606 745 619834
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.48066413552372 0.284921744780728 no 2392 0.315377612383606 747 688662
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.480979733472297 0.284803121407884 no 2393 0.31526545134468 744 16486 A toxic proline analog.
SGTC_2051 5263410 176 µM -0.48129088566798 0.284686192129909 no 2394 0.315154886957762 763 227584
SGTC_3034 9090421 49.47 µM -0.481839315864134 0.284480150900052 no 2395 0.314960048850907 757 17173761
SGTC_1247 0448-0043 5.84 µM -0.482046566279696 0.284402306978801 no 2396 0.314886433412454 765 3089013 YGL099W LSG1
SGTC_3290 9121031 71.43 µM -0.482464307134567 0.284245433112938 no 2397 0.314738074030918 723 17014854
SGTC_40 0327-0103 19.753 µM -0.48438874327294 0.283523285999443 no 2398 0.31405500287567 725 409036
SGTC_2071 5230951 39.92 µM -0.485457884836363 0.283122469535332 no 2399 0.313675790104752 756 1799272
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.486213165810075 0.282839482009757 no 2400 0.313408018820162 746 16623 A steroid.
SGTC_227 fluconazole 33.516 µM -0.486599191334443 0.282694899035119 no 2401 0.313271198371935 761 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_1480 1070-0044 41.2 µM -0.487098886148983 0.2825077948362 no 2402 0.313094127863367 746 3124987
SGTC_1186 1319-0216 26 µM -0.487280331109091 0.282439869879127 no 2403 0.313029842179149 739 4565136
SGTC_2597 laccaic acid a 100 µM -0.487362766182237 0.282409012433787 no 2404 0.313000637430762 751 5491415 A textile dye.
SGTC_879 0831-1030 162 µM -0.487607777049785 0.282317308502396 no 2405 0.312913842945416 764 1549252
SGTC_3088 9117578 49.47 µM -0.490224383065293 0.281338846297389 no 2406 0.311987564278013 773 678341
SGTC_1166 k206-0078 225 µM -0.49372967926637 0.280030635139287 no 2407 0.31074855089479 732 5404595
SGTC_1922 5578187 25 µM -0.494227052736369 0.279845249612426 no 2408 0.3105729181147 710 1350412
SGTC_2859 9028643 45.46 µM -0.49560200137434 0.279333076313488 no 2409 0.310087620244404 750 17151580
SGTC_2144 5628481 200 µM -0.495670954585936 0.279307402992188 no 2410 0.310063291418724 748 2818399
SGTC_1111 tnp00062 510.699 nM -0.496526817994507 0.278988835186558 no 2411 0.309761385577335 737 676306
SGTC_766 1391-0721 126 µM -0.496847802825478 0.278869404426464 no 2412 0.309648191234692 775 1020919 YIL115C NUP159
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -0.49753061442115 0.278615429379333 no 2413 0.309407459815009 755 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_255 tunicamycin 200.472 nM -0.499862395570303 0.277748962316906 no 2414 0.308585986140965 764 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2031 5180455 200 µM -0.500458519237344 0.277527659991464 no 2415 0.308376128509649 769 29949
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.501160832748716 0.277267046827699 no 2416 0.308128968438677 787 165506
SGTC_1723 st034307 2.5525 µM -0.501254973282404 0.277232122437116 no 2417 0.308095844856191 752 867466
SGTC_1883 5-benzylidenerhodanine 20 µM -0.501335110309478 0.277202394783165 no 2418 0.308067649674114 765 1273210
SGTC_2415 st077333 57.7 µM -0.501341182129797 0.277200142442558 no 2419 0.308065513428406 783 2766255
SGTC_2775 cyproheptadine 69.59 µM -0.502019401105817 0.276948613608308 no 2420 0.307826936906788 773 2913 A selective serotonin reuptake inhibitor.
SGTC_282 k297-0036 65.7 µM -0.502449187417963 0.276789278040527 no 2421 0.307675793370833 764 5061378
SGTC_3 0833-0587 95.581 µM -0.503807819773606 0.27628588500073 no 2422 0.30719821603069 756 5382644
SGTC_558 k064-0027 21.3 µM -0.504278103599756 0.276111742718136 no 2423 0.307032981113123 743 5088526
SGTC_1287 0971-0001 34.6 µM -0.504374575945575 0.276076026453335 no 2424 0.306999090254073 737 4665869
SGTC_3145 9085516 49.47 µM -0.505440985567955 0.275681368456128 no 2425 0.306624569099072 750 25236195
SGTC_1118 chelidonine 707.474 nM -0.505583181459956 0.275628765413962 no 2426 0.306574645398021 769 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1238 0333-0287 48.8 µM -0.505868436899589 0.275523254716701 no 2427 0.306474505596439 746 7226
SGTC_2108 5365811 200 µM -0.506848130053711 0.275161035727907 no 2428 0.306130691361764 735 780283
SGTC_1740 st038286 13.222 µM -0.50816806073274 0.274673392811437 no 2429 0.305667743852023 731 716786
SGTC_2533 agelasine 13.65 µM -0.508246921594165 0.274644271491042 no 2430 0.305640094312019 760 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2636 apigenin dimethyl ether 100 µM -0.510381692473012 0.273856533677226 no 2431 0.304892040140106 785 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_2066 5222451 176 µM -0.510957530013994 0.273644239109459 no 2432 0.304690397846347 770 2281147
SGTC_3344 9148862 3.898 µM -0.513492727294455 0.272710555032239 no 2433 0.303803348411217 791 4905352
SGTC_1061 3448-9325 110 µM -0.513677774486817 0.272642466228595 no 2434 0.3037386467131 791 723482
SGTC_2329 6138490 200 µM -0.513951491760288 0.272541766411538 no 2435 0.303642952823115 769 720019
SGTC_326 k292-0812 17.5 µM -0.514103193199772 0.272485963831718 no 2436 0.303589922505153 765 3579357
SGTC_2297 7971671 152.32 µM -0.515796103478054 0.271863620852525 no 2437 0.302998412147605 779 909016
SGTC_104 0074-0074 590.992 µM -0.516832102039873 0.271483119056025 no 2438 0.302636684222094 750 3943124
SGTC_2095 5432005 200 µM -0.517060998351007 0.271399085759006 no 2439 0.302556789187265 805 783734
SGTC_3246 9135460 32.98 µM -0.518785903709175 0.270766248967754 no 2440 0.301955024497176 767 41446951
SGTC_2308 7584454 197.62 µM -0.519032201461267 0.270675946887793 no 2441 0.301869142919727 775 893577
SGTC_900 1112-0045 141 µM -0.519627796726446 0.270457641290426 no 2442 0.30166151015125 764 56211 YIL048W NEO1
SGTC_753 1322-0200 289 µM -0.52083488115975 0.270015474467521 no 2443 0.301240900894619 776 5403907
SGTC_2445 5742597 35.57 µM -0.521621687487448 0.269727454485438 no 2444 0.300966880067571 754 1774255
SGTC_2571 chrysanthemic acid 100 µM -0.522553175399379 0.269386671085942 no 2445 0.300642616388074 808 2743 An insecticide.
SGTC_2743 auranofin 4.32 µM -0.523352430195229 0.269094437139374 no 2446 0.300364510643136 729 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2817 7995342 71.43 µM -0.524227478265312 0.268774673200095 no 2447 0.300060165527088 796 18879975
SGTC_1382 3002-2117 298 µM -0.525493542004743 0.268312360680565 no 2448 0.299620070757391 804 1497314
SGTC_815 1582-0027 36.9 µM -0.526869766678952 0.267810276213012 no 2449 0.299142015116677 762 3128206
SGTC_1371 2421-0008 32.7 µM -0.527225214241504 0.267680676157648 no 2450 0.299018600485763 778 2827552
SGTC_2391 6285546 200 µM -0.52810758356461 0.267359091368406 no 2451 0.298712333804084 755 846083
SGTC_2654 protoveratrine a 100 µM -0.528728127420537 0.267133047231225 no 2452 0.298497031087762 797 5702278 A heart drug and vasodilator.
SGTC_772 k072-0172 35.3 µM -0.530240917721605 0.266582391048963 no 2453 0.297972452329961 746 5861980
SGTC_1300 1094-0077 113 µM -0.530434584787453 0.266511937638053 no 2454 0.297905326230645 760 5532636
SGTC_621 3584-0052 32.1 µM -0.531418744954569 0.266154059311227 no 2455 0.297564317346095 789 2273927
SGTC_995 3931-2021 34.6 µM -0.531796068880704 0.266016914438297 no 2456 0.29743362287937 779 730143
SGTC_1446 4239-0190 62 µM -0.532042317156274 0.265927430573315 no 2457 0.297348343496123 782 1340085
SGTC_590 k048-0076 22.4 µM -0.534719967661054 0.26495538796825 no 2458 0.296421755940092 780 6832814
SGTC_1695 st026914 34.495 µM -0.536189201804989 0.264422793740829 no 2459 0.295913897803463 772 3289191
SGTC_957 1187-1561 14.1 µM -0.536413041570106 0.264341700163544 no 2460 0.295836560031275 772 1538454
SGTC_184 1494-0393 24.714 µM -0.537025507046412 0.264119878423614 no 2461 0.295624997578143 782 3090647
SGTC_2216 7189485 200 µM -0.538693394697127 0.263516286725398 no 2462 0.29504921609744 764 731273
SGTC_1832 st054113 55 µM -0.539394838078387 0.263262651899229 no 2463 0.294807221026516 772 1251267
SGTC_789 1309-1135 70.6 µM -0.539791868631066 0.263119144950037 no 2464 0.294670287691009 753 3092424
SGTC_552 k242-0005 476 µM -0.540096710756815 0.263008986700163 no 2465 0.294565169476622 811 4088318
SGTC_82 0054-0107 293.755 µM -0.541503515027948 0.262500927188437 no 2466 0.294080287766732 779 3104697
SGTC_855 0428-0020 25 µM -0.541841775273978 0.26237884135253 no 2467 0.293963755011525 753 6812414
SGTC_3071 9117417 49.47 µM -0.542152752756358 0.262266628146772 no 2468 0.293856640179822 766 45595590 YGL055W OLE1
SGTC_3057 9095946 49.47 µM -0.542418841502394 0.262170632126248 no 2469 0.293765001412455 791 24540043
SGTC_2262 9014885 67.46 µM -0.542860873495985 0.26201120140642 no 2470 0.293612798479335 759 6457424
SGTC_2166 5933061 31.504 µM -0.543727598634203 0.261698738022066 no 2471 0.293314468844746 759 2877375
SGTC_2940 9060638 45.86 µM -0.544058492332719 0.261579497870423 no 2472 0.293200611214276 754 4027022
SGTC_3180 9109287 49.47 µM -0.544771142281017 0.261322783587918 no 2473 0.292955464209768 759 18891271
SGTC_731 3966-0296 387 µM -0.546224478745058 0.260799656924664 no 2474 0.292455820793683 756 660956
SGTC_1304 1165-0502 251 µM -0.546601889311937 0.260663896632515 no 2475 0.292326135407564 758 767425
SGTC_231 b-estradiol 524 µM -0.547308954952875 0.260409652360653 no 2476 0.292083246336555 760 450 A steroid.
SGTC_2762 leflunomide 42.06 µM -0.547452878659515 0.260357916410919 no 2477 0.292033817604467 788 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -0.547607067733372 0.260302496266803 no 2478 0.291980867686014 774 94937 An inhibitor of serotonin biosynthesis.
SGTC_3082 9117008 49.47 µM -0.548372025562709 0.26002763755101 no 2479 0.291718240394283 768 41448529
SGTC_93 0109-0045 59.227 µM -0.548685269842546 0.259915128249201 no 2480 0.291610728341717 786 88733
SGTC_1962 st076595 64.5 µM -0.54968289811322 0.259556973198021 no 2481 0.291268444413728 781 279619
SGTC_2347 9049783 174.81 µM -0.551005319658001 0.259082608335796 no 2482 0.290815013945408 811 6467988 YPL169C MEX67
SGTC_1914 st062367 72.6 µM -0.551079717776169 0.259055934366663 no 2483 0.290789514207194 776 978205
SGTC_2197 6588183 93.1375 µM -0.552475110058103 0.258555907375819 no 2484 0.290311441363511 776 884136
SGTC_841 0251-0215 91.2 µM -0.553039113361391 0.258353943504727 no 2485 0.290118313716514 790 3888614
SGTC_4 0960-0234 25.671 µM -0.554207413008482 0.257935847426259 no 2486 0.289718452812672 763 6821112
SGTC_1952 st077036 64.1 µM -0.555127175736128 0.257606941674568 no 2487 0.289403837938003 782 2937007
SGTC_253 dyclonine 31.25 µM -0.555252105236499 0.257562283881413 no 2488 0.289361116823663 777 3180 An oral anasthetic.
SGTC_1315 1237-0019 3.69 µM -0.55580401588931 0.257365043844877 no 2489 0.289172419943804 765 825140
SGTC_969 1313-0238 134 µM -0.559684633877388 0.255980420592019 no 2490 0.287847282633111 792 5212874
SGTC_768 0384-0033 77.3 µM -0.56071676902868 0.255612805190024 no 2491 0.287495316864922 784 3965305 YMR134W ERG29
SGTC_2188 6126565 140.678 µM -0.560959330740308 0.255526452057499 no 2492 0.28741263105809 772 874518
SGTC_966 1300-0360 30.2 µM -0.562365581535993 0.255026120482762 no 2493 0.286933482119858 799 70588
SGTC_909 3448-9333 149 µM -0.563058495310019 0.25477977652177 no 2494 0.286697526295808 781 3344074
SGTC_2069 5228469 200 µM -0.563206320310525 0.254727238064394 no 2495 0.2866471998069 802 2835210
SGTC_1651 st011928 86.1 µM -0.566098803261989 0.253700363754805 no 2496 0.285663308395618 775 720198
SGTC_2318 6029776 164 µM -0.568582601393526 0.252820316555271 no 2497 0.284819717439069 810 818325
SGTC_3324 9138759 60.749 µM -0.56928348920529 0.25257227246964 no 2498 0.284581884882585 786 45595710
SGTC_2263 7948595 193.29 µM -0.570846989758811 0.252019412192613 no 2499 0.284051683585462 760 2971371
SGTC_1681 tripelennamine 100 µM -0.570887274606949 0.25200517574619 no 2500 0.284038028769911 762 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1377 2944-0135 198 µM -0.571002823717385 0.251964343672748 no 2501 0.283998864377387 779 1894137
SGTC_1436 4092-1007 8.32 µM -0.5716361358993 0.251740609516011 no 2502 0.283784254477599 753 2881121
SGTC_1027 k015-0025 8.67 µM -0.572687793233225 0.25136931581792 no 2503 0.283428051977022 777 3598955
SGTC_1520 flindersine 88 µM -0.576493869383988 0.25002798194741 no 2504 0.282140706243792 771 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_42 0133-0086 60.653 µM -0.578447478355853 0.249340970686995 no 2505 0.281481023606336 816 162923 Model of phenazepam hydroxylation.
SGTC_3051 9093778 49.47 µM -0.578837022997145 0.249204102494976 no 2506 0.281349573612276 809 17217378
SGTC_3052 9092717 49.47 µM -0.580486881243686 0.248624860921086 no 2507 0.280793165492067 814 25237534
SGTC_1293 1000-1278 195 µM -0.581398958217027 0.248304951859547 no 2508 0.280485799715512 803 678847
SGTC_292 k038-0015 474 µM -0.581687277379965 0.248203870195636 no 2509 0.280388671361916 803 46368540
SGTC_1631 benzylvanillin 81.9 µM -0.582236635781953 0.248011331678055 no 2510 0.280203649747215 776 75506
SGTC_2502 avocadyne acetate 18.59 µM -0.583405428538702 0.247601959784408 no 2511 0.279810202139497 767 3952079
SGTC_2732 terfenadine 20 µM -0.584085301006604 0.247363999304267 no 2512 0.279581461825053 806 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_2346 9031566 143.75 µM -0.58581257696446 0.246759989927039 no 2513 0.279000735496844 778 4771086
SGTC_202 3594-0513 34.79 µM -0.585923471159137 0.246721238442803 no 2514 0.27896347188334 795 708429
SGTC_524 r073-0010 27.8 µM -0.5863784047621 0.246562298024944 no 2515 0.278810626555509 810 2772106
SGTC_1003 4049-0218 100 µM -0.587863514772837 0.246043826295029 no 2516 0.278311953827109 801 295161
SGTC_3161 9100388 49.47 µM -0.588942163801946 0.24566762250267 no 2517 0.277950036024084 807 25236368
SGTC_598 3937-0236 20.2 µM -0.589187208037986 0.245582200737813 no 2518 0.277867848656389 809 1379313
SGTC_235 0330-0087 5 mM -0.589433166607078 0.245496476285118 no 2519 0.277785366554737 779 46494818 YHR062C RPP1
SGTC_1045 1348-1485 165 µM -0.589953011273414 0.245315346650558 no 2520 0.277611076213178 785 6810614
SGTC_842 0271-0008 11.1 µM -0.59043589336513 0.245147160273469 no 2521 0.277449226335919 786 1221709
SGTC_9 0092-0002 10.449 µM -0.591518558685548 0.244770296690583 no 2522 0.277086512002806 795 759368
SGTC_1369 1866-0067 208 µM -0.594602395367457 0.243698559460613 no 2523 0.276054639265462 790 3531355
SGTC_2222 6885208 172.143 µM -0.595534800296125 0.243375016835023 no 2524 0.275743022125592 777 609514
SGTC_44 0929-0055 61.211 µM -0.596556459143745 0.243020769954184 no 2525 0.275401774240535 767 1379590
SGTC_2041 5107442 45.335 µM -0.597909521983793 0.242552042656504 no 2526 0.274950152999028 805 793005
SGTC_1699 st031318 29.054 µM -0.598840873417314 0.242229689109623 no 2527 0.274639501503513 790 5340658
SGTC_614 0462-0418 107 µM -0.599591363607305 0.241970103174328 no 2528 0.274389302140254 778 5188303
SGTC_64 000l-0018 272.079 µM -0.600761860023352 0.241565543283197 no 2529 0.27399930528618 799 6811119
SGTC_1960 st011366 51.8 µM -0.601138043548894 0.241435600613702 no 2530 0.273874023164838 810 3972846
SGTC_1872 amphotericin b 148 nM -0.601756849045781 0.241221933211315 no 2531 0.273668001168159 783 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2763 lisinopril 49.32 µM -0.603318184014396 0.240683276821454 no 2532 0.27314851917083 814 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_3282 9108498 15.4605 µM -0.603845375021107 0.240501545293642 no 2533 0.272973224410526 805 16459645
SGTC_1297 1068-0111 14.1 µM -0.606879878362848 0.239456955753722 no 2534 0.271965316268688 800 767057
SGTC_2539 epi(13)torulosol 80 µM -0.612074666766957 0.237674480892944 no 2535 0.270244178819 801 6708597
SGTC_583 1488-1091 88.9 µM -0.61317750823796 0.237297004593718 no 2536 0.26987948747709 819 4303273
SGTC_288 1315-0019 35.1 µM -0.613290697261825 0.237258281332469 no 2537 0.269842071693638 814 6811474
SGTC_115 0527-0192 112.043 µM -0.613417253807584 0.237214988998954 no 2538 0.269800240215273 826 4233931
SGTC_2685 mycophenolic acid 18.85 µM -0.613988539906423 0.237019618050274 no 2539 0.269611450086474 794 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2456 5770359 74.46 µM -0.614745467465362 0.236760896877702 no 2540 0.269361413913759 825 3118787
SGTC_829 1635-0120 117 µM -0.615618517242264 0.23646267760322 no 2541 0.269073163504883 809 285054
SGTC_293 4049-0273 38.5 µM -0.616871214226215 0.236035138545671 no 2542 0.268659837494823 799 1380311
SGTC_525 k781-2675 26.7 µM -0.620405147196065 0.234831324187828 no 2543 0.267495542262966 794 3651118 YDL195W SEC31
SGTC_2495 cafestol 54.53 µM -0.62259210692882 0.234088051890415 no 2544 0.266776299686486 822 16667697 An anti-infammatory.
SGTC_29 0299-0004 12.984 µM -0.62295815967679 0.233963770578023 no 2545 0.266656008606373 799 16871 A napthoquinone isolated from Swertia calycina.
SGTC_2922 7999257 32.47 µM -0.62363908704077 0.233732681096044 no 2546 0.266432317411215 820 2988377
SGTC_2443 5493264 126.67 µM -0.625773403487873 0.233009168662177 no 2547 0.265731789567217 818 5340055
SGTC_2649 anisomycin 9.56 µM -0.628356988991362 0.232135024914792 no 2548 0.264885053225745 809 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_2381 9035592 200 µM -0.629141522254623 0.231869943595034 no 2549 0.26462820441932 809 4749657
SGTC_1336 1486-0901 104 µM -0.629593604082889 0.231717268933075 no 2550 0.264480254638663 802 5006114
SGTC_2154 5570129 200 µM -0.629634057333796 0.231703610008028 no 2551 0.264467017827303 836 673366
SGTC_3138 9097216 49.47 µM -0.63097968921835 0.231249516984379 no 2552 0.264026902399498 817 25237486
SGTC_1653 st012112 65 µM -0.63100050897509 0.231242495112055 no 2553 0.264020095820846 820 720429
SGTC_509 pifithrin 175 µM -0.632452087457585 0.230753215083287 no 2554 0.263545753523185 823 4817 A p53 inhibitor.
SGTC_2402 5553605 200 µM -0.632735525888716 0.230657744705993 no 2555 0.263453183170213 818 6758546
SGTC_1229 0139-0193 12.2 µM -0.634283681711328 0.230136670065627 no 2556 0.262947852045127 805 3090752
SGTC_3240 9133527 49.47 µM -0.6356178424994 0.229688150173739 no 2557 0.262512768557879 829 17617455
SGTC_603 3794-0023 45.9 µM -0.636859677165524 0.229271108907415 no 2558 0.262108124956388 825 3802260
SGTC_836 0330-0104 1.35 µM -0.638243594834746 0.228806852984323 no 2559 0.261657561456213 798 46494820
SGTC_2085 5307070 144.047 µM -0.63889078257909 0.228589925381151 no 2560 0.261446992357674 828 2840351
SGTC_648 0375-0473 33.3 µM -0.639573035157337 0.228361369694295 no 2561 0.261225108811537 808 1713139
SGTC_1873 rapamycin 2 nM -0.640442351504368 0.228070333507297 no 2562 0.260942528268182 793 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1923 st058458 19.1 µM -0.640979793173301 0.227890509186594 no 2563 0.260767905794252 843 3534982
SGTC_398 bronopol 33.3 µM -0.641280657218628 0.227789876965902 no 2564 0.260670177026282 804 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_151 3013-0144 2.285 µM -0.644947906605141 0.226565277042642 no 2565 0.259480472423331 817 906558 YHR107C CDC12
SGTC_738 1315-0003 72.4 µM -0.645073527793511 0.226523394457334 no 2566 0.259439768967823 832 6251474
SGTC_139 0099-0334 718.624 µM -0.645138680859189 0.226501673897279 no 2567 0.259418659537361 830 97690
SGTC_159 3970-0959 50 µM -0.645231242905536 0.226470817824433 no 2568 0.259388671191346 813 6615653
SGTC_1805 st050013 60.3 µM -0.645702954124351 0.226313607140636 no 2569 0.259235873533626 817 4037144
SGTC_550 4123-0385 25.7 µM -0.646973820236554 0.225890363113915 no 2570 0.25882444361547 819 5731123
SGTC_578 3460-0051 92 µM -0.648934568208328 0.225238242506465 no 2571 0.2581903349397 840 2876744
SGTC_3079 9117512 49.47 µM -0.649392340418281 0.225086146788026 no 2572 0.258042406806588 858 7185044
SGTC_800 3448-7362 155 µM -0.649931394442523 0.224907119659486 no 2573 0.257868268998685 827 15991913
SGTC_849 0386-0493 241 µM -0.65043611823888 0.224739567257906 no 2574 0.257705276636181 827 726119
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.651008477268831 0.22454964776924 no 2575 0.25752050730775 811 6708514
SGTC_2059 5238311 157 µM -0.651226536250867 0.224477315659929 no 2576 0.257450131465962 819 703021
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.651376151045415 0.224427694747033 no 2577 0.257401850920173 805 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_3294 9122953 26.2835 µM -0.651952167018142 0.224236712689366 no 2578 0.25721601506937 816 16459826
SGTC_2187 6125751 200 µM -0.653275726794606 0.223798227153123 no 2579 0.256789269009339 815 874498
SGTC_559 1550-0661 158 µM -0.653385617125866 0.22376184322733 no 2580 0.256753854420017 813 5830875
SGTC_361 000s-0510 1.45 µM -0.653545728261183 0.223708837561234 no 2581 0.256702259617379 813 660
SGTC_1588 farnesol 29.9 µM -0.653705700815741 0.223655884903291 no 2582 0.256650714863105 813 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1261 0712-0010 12.7 µM -0.654334043228731 0.223447965709137 no 2583 0.256448308834539 822 2840123
SGTC_2140 5586273 200 µM -0.65436402859252 0.223438046269163 no 2584 0.256438651820205 814 854421
SGTC_1814 st052110 31.539 µM -0.656028772373773 0.222887726583625 no 2585 0.255902805853227 825 674163
SGTC_2812 7970281 58.44 µM -0.656341243436606 0.222784518162143 no 2586 0.255802293167253 827 2233435
SGTC_26 0302-0163 425.158 µM -0.657498448635309 0.222402533409141 no 2587 0.255430234087354 851 3100915
SGTC_1296 1068-0102 11.9 µM -0.658997068544337 0.221908405821815 no 2588 0.25494882554941 816 767053
SGTC_1391 3442-0225 151 µM -0.659197392047135 0.221842402341657 no 2589 0.254884510705399 813 5227075
SGTC_2643 anethole 100 µM -0.660656101975168 0.221362118329758 no 2590 0.254416440884761 846 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_423 5-fluorouracil 457 µM -0.660847797329124 0.221299046373123 no 2591 0.254354963319842 826 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_933 2914-0560 114 µM -0.660897622815316 0.221282654383432 no 2592 0.254338985336695 802 463887
SGTC_757 1066-0008 322 µM -0.661402568933343 0.221116572328366 no 2593 0.254177089448562 804 6842497
SGTC_3304 9125678 46.087 µM -0.663058342563993 0.220572471746691 no 2594 0.253646594495992 825 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2393 9031399 185.94 µM -0.664954802350952 0.21995022324828 no 2595 0.253039701084995 839 1526623 YDL150W RPC53
SGTC_3006 9075424 71.4286 µM -0.665175059349854 0.219878019943277 no 2596 0.252969265343506 817 7465181
SGTC_2374 9071832 200 µM -0.665712551705933 0.219701879592674 no 2597 0.252797424577397 815 17381698
SGTC_3192 9110362 49.47 µM -0.666324540732051 0.219501424786782 no 2598 0.252601841457001 837 16649480
SGTC_2606 farnesol 9.78 µM -0.667968215711073 0.218963565278175 no 2599 0.252076940750575 843 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_1981 st071826 47 µM -0.673634717985129 0.217115138672405 no 2600 0.250271787536244 811 11838600
SGTC_216 k038-0035 28.382 µM -0.673952036699055 0.21701189580371 no 2601 0.250170903733938 828 4444231 YPR107C YTH1
SGTC_3273 9137859 49.47 µM -0.674555829111117 0.216815524181111 no 2602 0.249979002136805 863 2377234
SGTC_2653 dihydrofissinolide 100 µM -0.676685635060556 0.216123667540308 no 2603 0.249302716295893 830 6857746
SGTC_2881 9058953 51.95 µM -0.679078963339407 0.215347734807768 no 2604 0.248543915419154 792 17122249
SGTC_291 SEC14.278 35.5 µM -0.679894314016481 0.215083762349666 no 2605 0.248285691088669 827 1068044
SGTC_620 0109-0052 432 µM -0.679944008685465 0.215067679613768 no 2606 0.2482699572441 838 493037
SGTC_2180 6301957 200 µM -0.680115209356328 0.215012279114215 no 2607 0.248215757417246 832 845462
SGTC_2081 5214970 32.255 µM -0.682110991169792 0.214367056214944 no 2608 0.247584385568832 826 2063512
SGTC_470 aa-861 153 µM -0.682819154267125 0.214138382777079 no 2609 0.247360562336595 824 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2012 4023501 200 µM -0.682942068874157 0.214098706797573 no 2610 0.247321724755447 849 3477460
SGTC_311 1315-0136 58 µM -0.684367250092377 0.213638980693312 no 2611 0.246871645437066 826 6759207
SGTC_425 3825-7017 13.1 µM -0.684440605639098 0.213615333689468 no 2612 0.246848491259513 821 3397440
SGTC_131 0141-0277 33.849 µM -0.68456132468526 0.213576421836987 no 2613 0.246810389647397 841 1547771
SGTC_2436 5633522 8.09 µM -0.684897304668513 0.213468145812053 no 2614 0.246704363479389 835 5724242
SGTC_2944 9067346 25.62 µM -0.686600732486421 0.212919675876047 no 2615 0.246167183385909 838 6473075
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM -0.68669058721444 0.212890767290153 no 2616 0.246138864906658 824 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_719 2810-4230 27.3 µM -0.68813968147703 0.212424872701493 no 2617 0.245682411955278 828 721079
SGTC_1023 4482-3888 16 µM -0.689215534286124 0.212079363654693 no 2618 0.245343821271801 830 3303168
SGTC_710 3448-4187 58 µM -0.69265010970581 0.21097855460309 no 2619 0.244264577654377 821 3946412
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -0.692680767599885 0.210968743609393 no 2620 0.244254955588916 795 4000243
SGTC_1698 5-fluorocytosine 1.055 µM -0.69313920701629 0.210822067911219 no 2621 0.244111097476178 832 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2854 9024559 71.43 µM -0.693843935917468 0.210596709633419 no 2622 0.243890042956222 837 3163529
SGTC_2497 7-hydroxyflavone 100 µM -0.69466174821174 0.210335366816198 no 2623 0.243633652682796 853 5281894
SGTC_3031 9088762 49.47 µM -0.697404872321388 0.209460156642888 no 2624 0.242774726609845 836 205253
SGTC_2291 7917025 104.35 µM -0.69761500081669 0.209393202355111 no 2625 0.242708998897619 829 2964612
SGTC_2182 6325192 200 µM -0.699404235969751 0.208823599822484 no 2626 0.242149720669685 815 736248
SGTC_692 k241-0027 77.8 µM -0.701635152332366 0.208114668564089 no 2627 0.241453361799712 823 3600480
SGTC_667 1498-1044 59 µM -0.701851277937356 0.208046064626015 no 2628 0.241385958131627 857 6739982
SGTC_1339 1486-1321 22.7 µM -0.702354980203238 0.20788622812969 no 2629 0.241228906846208 838 3469382
SGTC_502 l-744,832 89.3 µM -0.703044738610444 0.207667469350313 no 2630 0.241013934518319 864 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2626 ethyl orsellinate 100 µM -0.705859598440778 0.206776139872973 no 2631 0.240137727296887 856 75653 A natural product.
SGTC_212 3807-4682 38.772 µM -0.706514345203442 0.206569138500325 no 2632 0.239934167464716 837 3125501 YBL034C STU1
SGTC_1966 st070145 16.1 µM -0.70704650796554 0.206400983113651 no 2633 0.239768788174983 850 3748532
SGTC_2341 7987486 176.74 µM -0.708073774143283 0.206076612030472 no 2634 0.239449722447296 817 1258686
SGTC_358 0075-0058 9.45 µM -0.710227880657155 0.205397410489858 no 2635 0.238781417064788 886 1069125
SGTC_2735 sertaconazole 140 nM -0.710464526555901 0.205322875883105 no 2636 0.238708060608068 873 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_1385 3091-4834 14.1 µM -0.710491539505691 0.205314368836061 no 2637 0.238699687808358 829 4072814
SGTC_2701 st077767 14.721 µM -0.710971953901518 0.205163109418423 no 2638 0.238550807793782 826 5721188
SGTC_823 0417-1665 178 µM -0.711589735167191 0.204968697128874 no 2639 0.238359432632868 860 3429856
SGTC_2345 9052315 157.45 µM -0.712981030056318 0.204531265712121 no 2640 0.237928747892623 849 6469265
SGTC_1844 rapamycin 4 nM -0.714295687598573 0.204118440449733 no 2641 0.237522179133256 833 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2587 piperic acid 92.2 µM -0.714634560644346 0.204012108948414 no 2642 0.23741744167738 824 5370536
SGTC_3223 9129970 49.47 µM -0.715503442074163 0.203739622379488 no 2643 0.23714900735232 860 17248386
SGTC_1231 0242-0792 125 µM -0.716692224976981 0.203367164445018 no 2644 0.236782012186251 845 3707635
SGTC_1199 1638-0010 4.46 µM -0.717142387604726 0.20322622997276 no 2645 0.236643121782052 843 3111136
SGTC_412 gemfibrozil 100 µM -0.718321341636034 0.202857405802785 no 2646 0.236279587052617 826 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_974 1326-0144 138 µM -0.719431467827676 0.20251047952714 no 2647 0.235937556942881 852 5411856
SGTC_313 3474-0040 5.03 µM -0.721022349701923 0.202013930818591 no 2648 0.235447881996941 843 1043375 YIL048W NEO1
SGTC_2299 7976368 114.88 µM -0.722404894203506 0.201583001090738 no 2649 0.235022789376909 841 2979718
SGTC_3009 9080819 71.4286 µM -0.722811739709699 0.201456295062301 no 2650 0.23489777689403 839 17027216
SGTC_1258 0671-0043 57.1 µM -0.723772834472703 0.201157165886466 no 2651 0.234602604788437 864 4298767
SGTC_379 3970-0972 5.9 µM -0.723783627392231 0.201153808233213 no 2652 0.234599291224518 853 2898042 YBL034C STU1
SGTC_210 3551-0445 56.827 µM -0.724687166836387 0.200872838315379 no 2653 0.234321984899531 848 2865180 YOR207C RET1
SGTC_681 1642-0006 26.6 µM -0.724777285664169 0.200844827358242 no 2654 0.234294336380233 867 4446530
SGTC_1845 st056753 3.01 µM -0.7250739361503 0.200752638278539 no 2655 0.234203336560476 835 5375839
SGTC_1637 st007924 17.4 µM -0.725380149290717 0.200657504089537 no 2656 0.234109423850835 832 683336
SGTC_1591 genipin 88.4 µM -0.725506017806285 0.20061840715455 no 2657 0.234070827201512 867 442424 A DNA cross-linking agent.
SGTC_393 acivicin 6.25 µM -0.725794294368532 0.200528880710164 no 2658 0.233982442605997 840 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_2128 5255449 168.493 µM -0.727895091487154 0.199877187218963 no 2659 0.233338904071301 833 736008
SGTC_2815 7968870 71.43 µM -0.72866592868345 0.199638383684953 no 2660 0.23310301954343 863 2977326 YHR190W ERG9
SGTC_3251 9135047 49.47 µM -0.728826797581156 0.199588568543703 no 2661 0.233053808622514 824 17682963
SGTC_3204 9114183 49.47 µM -0.728841215835191 0.199584104109584 no 2662 0.233049398259478 836 17027248
SGTC_2243 6634756 200 µM -0.729034303035323 0.199524322836582 no 2663 0.232990339773626 811 885676
SGTC_2656 pseudo-anisatin 100 µM -0.729340611615186 0.199429509471712 no 2664 0.232896667961231 873 6708809 A neurotoxin.
SGTC_2722 naftopidil 47.16 µM -0.729450414072574 0.199395528323676 no 2665 0.232863094514829 856 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1490 4089-0339 670 nM -0.730173042557027 0.199171979634752 no 2666 0.232642209092834 844 742542
SGTC_1846 st056244 14.8 µM -0.731705153835065 0.198698513077836 no 2667 0.232174275017153 861 5393182
SGTC_289 k017-0060 526 µM -0.731719170907139 0.198694184533803 no 2668 0.232169996373127 854 5512909
SGTC_250 brefeldin a 552.239 µM -0.731979540533995 0.198613791390327 no 2669 0.232090527772026 841 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_964 1287-0107 19.4 µM -0.732604866755172 0.198420792415271 no 2670 0.23189973097135 846 51516812 YPR165W RHO1
SGTC_1771 st048882 4.1505 µM -0.737192902398458 0.197008217541135 no 2671 0.230502524527141 847 4580403
SGTC_1384 3089-0840 101 µM -0.739896988064431 0.19617853578539 no 2672 0.229681251073295 836 1069836
SGTC_3216 9129716 49.47 µM -0.742383435559342 0.195417503860063 no 2673 0.228927526355352 830 8056934
SGTC_1321 1326-2144 215 µM -0.744246925575484 0.1948483190907 no 2674 0.22836355185714 863 3513030
SGTC_3228 9131799 49.47 µM -0.746283736061969 0.19422734992134 no 2675 0.227748017010261 860 17015818
SGTC_1675 st018485 24.5 µM -0.746769668885888 0.194079380231295 no 2676 0.227601303643742 863 3323024
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.747218760044753 0.193942690147998 no 2677 0.227465760881583 869 279621
SGTC_2131 toluylene red 5.2905 µM -0.749169652509498 0.193349577392871 no 2678 0.226877478935617 827 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM -0.749731547167147 0.193178954991351 no 2679 0.226708201711452 847 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1815 st051655 58.2 µM -0.750201273443671 0.193036390580658 no 2680 0.226566745983826 853 5984156
SGTC_1956 st077085 54 µM -0.75125352705314 0.192717259274518 no 2681 0.226250045947007 878 24208685
SGTC_1904 st060225 78 µM -0.751811140210125 0.192548275086953 no 2682 0.226082320819809 830 66595
SGTC_2426 5582046 32.21 µM -0.75282491556555 0.192241283450857 no 2683 0.22577756622142 850 2251934
SGTC_927 2425-1185 123 µM -0.753816479986788 0.19194130753441 no 2684 0.225479713443207 872 730375
SGTC_643 k048-0106 28.4 µM -0.754091613965461 0.191858122631037 no 2685 0.225397106289189 859 6763920
SGTC_2714 st079313 56.9 µM -0.754255447619644 0.191808599115899 no 2686 0.225347924460566 853 2939799
SGTC_1522 st012842 45.6 µM -0.754287316329127 0.191798966775462 no 2687 0.225338358381196 858 3491067 YOR116C RPO31
SGTC_19 0279-0214 38.434 µM -0.755670447504437 0.191381199787995 no 2688 0.224923403393071 855 3566274 YBR002C RER2
SGTC_2917 7979103 53.79 µM -0.757357985959825 0.190872244204051 no 2689 0.224417709896955 840 2980565
SGTC_952 1185-0122 232 µM -0.757435963449428 0.190848746560209 no 2690 0.224394358505624 852 678600
SGTC_1545 lovastatin 49.4 µM -0.757858766579272 0.190721370471607 no 2691 0.224267768526164 840 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_364 0083-0097 67.7 µM -0.758090076086527 0.190651706931481 no 2692 0.224198530132804 865 5207356
SGTC_2068 5226020 147 µM -0.759118041233442 0.190342303400429 no 2693 0.223890973903253 867 1810509
SGTC_1658 st012944 20 µM -0.759308094295951 0.190285133812268 no 2694 0.223834138323453 846 24207260
SGTC_296 1222-0039 74.9 µM -0.760122284347188 0.190040337882031 no 2695 0.223590746718892 846 5984176
SGTC_2687 chenodiol 100 µM -0.760820541126678 0.189830552922436 no 2696 0.223382131814953 833 5702181 A cholesterol synthesis inhibitor.
SGTC_1063 disulfiram 1.84 µM -0.764441148306609 0.188745059186935 no 2697 0.222302197654594 876 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_3343 9148379 18.9835 µM -0.76499471376608 0.188579432626146 no 2698 0.222137346213018 834 1955036
SGTC_919 tnp00227 403.569 nM -0.766541344270992 0.188117156551845 no 2699 0.221677130618108 883 1269246 A methoxyflavone. YNL221C POP1
SGTC_2098 5376439 882.5 nM -0.767970245868225 0.187690690888471 no 2700 0.221252431050779 852 2844116
SGTC_1355 1499-0035 1.68 µM -0.76823866292711 0.187610646625929 no 2701 0.221172703819484 878 1548538
SGTC_911 3456-4043 236 µM -0.772286454672044 0.186406119023329 no 2702 0.219972393085026 854 914281
SGTC_1077 5-fluorocytosine 377 nM -0.772318168419479 0.186396700711514 no 2703 0.219963003638989 881 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_2792 7535235 81.82 µM -0.772365589209602 0.186382618290382 no 2704 0.219948964259234 864 1281891
SGTC_628 1636-0253 16 µM -0.775586175706865 0.185427752463698 no 2705 0.218996682721337 867 4456143
SGTC_322 k048-0136 19.3 µM -0.778052127276315 0.184698683556639 no 2706 0.218269141678682 873 6823282
SGTC_1368 1852-0141 284 µM -0.778935949838224 0.184437812152921 no 2707 0.218008722830176 870 2838987
SGTC_1715 st032160 10.2275 µM -0.779729259231975 0.184203852154292 no 2708 0.217775126368513 840 5289825
SGTC_832 4083-0019 164 µM -0.779935413873869 0.184143084006246 no 2709 0.217714446086288 879 1990758
SGTC_2397 5161689 200 µM -0.779943293662094 0.184140761530822 no 2710 0.217712126915281 867 2259942
SGTC_2173 5763948 167 µM -0.780396072946961 0.184007340757105 no 2711 0.217578889332282 862 2867177
SGTC_3237 9133362 49.47 µM -0.781674566514316 0.18363093124368 no 2712 0.217202926187939 862 43845137
SGTC_2225 6654152 15.4 µM -0.782722782958026 0.183322677324937 no 2713 0.216894960171867 855 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_3253 9135987 49.47 µM -0.787024710029717 0.182060971760928 no 2714 0.215633700639843 857 4182430
SGTC_1361 1608-0041 5.61 µM -0.787537147422515 0.181911042488105 no 2715 0.215483745770853 859 X1361
SGTC_1106 tegaserod maleate 11.7 µM -0.788862681429625 0.18152357520393 no 2716 0.215096134651239 871 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2198 6589944 200 µM -0.789619765991656 0.181302503515361 no 2717 0.214874930606004 854 5290268
SGTC_1248 0469-0687 58.6 µM -0.790045810166178 0.181178171095939 no 2718 0.214750507664026 867 4017482
SGTC_1608 st001473 40.5 µM -0.791196213382614 0.180842715946068 no 2719 0.214414750411251 881 7292267
SGTC_169 k015-0017 16.025 µM -0.793573980618876 0.180150598912647 no 2720 0.213721742442202 900 1840002
SGTC_1239 0337-0584 35.4 µM -0.794530758107504 0.179872571277104 no 2721 0.21344325506748 885 914301 YML130C ERO1
SGTC_633 0437-0093 97.7 µM -0.796505546011791 0.179299575196864 no 2722 0.212869126633802 867 2831118
SGTC_771 0250-0039 27.3 µM -0.796587819559211 0.179275727986524 no 2723 0.212845226888615 874 3005115
SGTC_3151 9099821 49.47 µM -0.797139128118781 0.17911598117697 no 2724 0.212685116994797 865 17174189
SGTC_1942 st076330 65.2 µM -0.797840155764884 0.178912981232357 no 2725 0.212481627593959 874 24208414
SGTC_1232 0279-0259 161 µM -0.800244452271916 0.178217857989431 no 2726 0.211784589749852 862 1560000
SGTC_765 1319-0117 244 µM -0.801376295445325 0.177891212839257 no 2727 0.211456916956252 850 3487746 YGL099W LSG1
SGTC_2864 9034755 47.6 µM -0.802122305704658 0.177676124023565 no 2728 0.211241106643405 859 4930451
SGTC_1765 st044815 90.4 µM -0.802646383711726 0.177525120630885 no 2729 0.211089575421925 885 645695
SGTC_3020 9089140 49.47 µM -0.803595225879446 0.177251935447857 no 2730 0.21081539060032 882 17217859
SGTC_2866 9034245 58.44 µM -0.803974949107926 0.177142682142432 no 2731 0.210705721366285 859 6462273
SGTC_3262 9137218 49.47 µM -0.804114391826816 0.177102572607129 no 2732 0.210665456815444 820 17650664
SGTC_356 1634-0012 32.5 µM -0.805430882777272 0.176724177778481 no 2733 0.210285538204731 877 735457
SGTC_454 lyso-paf C-16 6.67 µM -0.805559373300894 0.176687273551579 no 2734 0.210248479420259 872 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_602 3130-1533 38.1 µM -0.806760859278908 0.176342426263568 no 2735 0.209902136714511 873 720941
SGTC_448 monastrol 171 µM -0.809890322950475 0.175446216777385 no 2736 0.209001607044322 886 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_2993 9054257 71.4286 µM -0.812372050491994 0.174737561087423 no 2737 0.208289089408439 865 6470217 YGL055W OLE1
SGTC_3250 9135583 49.47 µM -0.812418319164949 0.174724366375876 no 2738 0.208275819039895 871 7699353
SGTC_20 0481-0013 4.944 µM -0.814878848722499 0.174023593935513 no 2739 0.207570830712692 878 182045
SGTC_1459 k035-0031 35.7 µM -0.816086733613907 0.173680236444888 no 2740 0.20722526547708 858 3877128 YMR208W ERG12
SGTC_894 0960-0238 55.9 µM -0.817494693884174 0.173280549244083 no 2741 0.206822890181805 888 6741907 YDL195W SEC31
SGTC_1208 2323-2347 50.3 µM -0.818042716953416 0.17312513669896 no 2742 0.20666639800534 881 5412760
SGTC_817 1391-0715 46 µM -0.818461804091483 0.173006348709345 no 2743 0.206546771797274 884 1353946
SGTC_2831 7999036 19.48 µM -0.819159629743902 0.172808669036089 no 2744 0.206347672186734 892 2988270
SGTC_689 0833-0039 98 µM -0.819653801714342 0.172668767372276 no 2745 0.206206746690465 906 5374726
SGTC_2047 4141938 200 µM -0.819832277111627 0.172618258170338 no 2746 0.2061558639946 880 3807862
SGTC_69 0096-0274 206.684 µM -0.822236555516646 0.171938756842149 no 2747 0.205471138698704 895 6741392
SGTC_2007 4011539 71.82 µM -0.822303847104171 0.171919763378028 no 2748 0.205451993871601 884 45595301
SGTC_1496 4469-0713 57.4 µM -0.822418603544883 0.171887375757887 no 2749 0.205419347476158 892 746691
SGTC_2416 tofa 880 nM -0.824986008555411 0.171163797862581 no 2750 0.20468976707333 877 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_1940 st075990 51.1 µM -0.825353547161593 0.171060373190342 no 2751 0.204585449770003 909 1084979
SGTC_3029 9088683 49.47 µM -0.827428215961215 0.170477315149838 no 2752 0.203997196685775 854 25236615
SGTC_984 1492-0255 2.91 µM -0.829642574359391 0.169856405020117 no 2753 0.203370449071507 882 1585198
SGTC_1113 artemisinin 1.17947 µM -0.831048235059963 0.169463008552772 no 2754 0.202973190486443 874 2240 An anti-malaria and mitochondrial poison.
SGTC_3244 9134489 49.47 µM -0.832855258336731 0.168958144040297 no 2755 0.202463182827855 900 16584271
SGTC_1381 2324-0066 62.1 µM -0.833454518178287 0.168790930292234 no 2756 0.202294219241795 873 10885928
SGTC_2487 5918373 44.05 µM -0.833498551146007 0.168778647801408 no 2757 0.202281807306672 875 2876279
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -0.834363965042644 0.168537367102805 no 2758 0.202037958431005 888 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_3037 9091026 49.47 µM -0.837407693276184 0.167690526568058 no 2759 0.201181721414373 878 25236398 YIL048W NEO1
SGTC_107 0358-0022 2.6945 µM -0.837425934420764 0.167685459704753 no 2760 0.201176596531142 897 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2955 9076254 12.21 µM -0.838784634672085 0.167308329200377 no 2761 0.200795087305067 865 16459619
SGTC_2667 digitoxin 100 µM -0.839467365098251 0.167119032205665 no 2762 0.200603547560591 842 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2405 ticlatone 3.52 µM -0.839698894195869 0.167054868744646 no 2763 0.200538617083932 914 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_3048 9093155 49.47 µM -0.839928548204798 0.166991240620296 no 2764 0.20047422493013 844 25236002
SGTC_1175 0741-0056 27.6 µM -0.839983503821416 0.166976016890793 no 2765 0.200458817894059 890 765927
SGTC_2087 5276107 200 µM -0.840115444176391 0.166939470608979 no 2766 0.200421830769344 876 144405
SGTC_2525 harmine 47.85 µM -0.840728769524193 0.166769652787805 no 2767 0.200249949774774 850 5280953 A monoamine oxidase inhibitor
SGTC_1029 k015-0030 64.7 µM -0.842815096678556 0.166192824250033 no 2768 0.199665931732372 873 2208316
SGTC_89 0302-0250 142.109 µM -0.842979952285264 0.166147299913676 no 2769 0.199619828026798 904 4203518 YLR208W SEC13
SGTC_2920 7982904 15.77 µM -0.843932577965298 0.165884393241769 no 2770 0.199353541135542 870 6456808
SGTC_2962 9082311 13.18 µM -0.843959751212769 0.165876897885871 no 2771 0.199345948552594 894 16459453
SGTC_2340 7987427 183.45 µM -0.848872696834197 0.164525329400988 no 2772 0.197976066484744 870 2239331
SGTC_2057 5236571 38.335 µM -0.849291810607566 0.164410361070682 no 2773 0.197859468318545 891 54684039 YBR257W POP4
SGTC_2023 5144124 124 µM -0.850022224312262 0.164210123642781 no 2774 0.197656365158132 879 2830192
SGTC_1090 efavirenz 20.7 µM -0.851550928547081 0.163791552979519 no 2775 0.197231692655089 876 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_2018 5133068 143 µM -0.852265435651342 0.163596153270852 no 2776 0.197033392736317 898 785362
SGTC_2313 7726885 200 µM -0.852990671468894 0.1633979743786 no 2777 0.196832238686903 897 726423
SGTC_2363 9053361 176 µM -0.85303426133591 0.163386067924414 no 2778 0.196820152405412 887 6469797 YMR079W SEC14
SGTC_474 dl-dihydrosphingosine 5 µM -0.855353546081756 0.162753374346028 no 2779 0.19617772622777 852 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_105 0111-0055 734.78 µM -0.85618730414261 0.162526317679646 no 2780 0.195947091956603 894 5179370
SGTC_3189 9110682 49.47 µM -0.856859207796867 0.162343488748499 no 2781 0.195761349629261 902 17122418
SGTC_2223 6903751 107.57 µM -0.857115482613685 0.162273790147982 no 2782 0.195690532693126 886 5598863
SGTC_1298 1079-1278 263 µM -0.857313102029668 0.162220057256134 no 2783 0.195635934743228 889 2840950
SGTC_1707 st032323 6.317 µM -0.858340274904999 0.161940954666438 no 2784 0.195352298192497 882 3132057 YMR211W DML1
SGTC_2236 dapsone 200 µM -0.861482152586904 0.161089189214122 no 2785 0.194486273345433 878 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_2845 9003024 42.97 µM -0.861996521027932 0.160950022519853 no 2786 0.194344716136092 875 2990173
SGTC_582 0987-0078 156 µM -0.862682506538761 0.160764545543159 no 2787 0.194156026552584 906 1625765
SGTC_87 0100-0052 35.5 µM -0.863685947378648 0.160493486386865 no 2788 0.193880217672059 907 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1314 1222-0010 41.1 µM -0.864020092436361 0.160403290194462 no 2789 0.19378842654399 899 3526027
SGTC_2689 tacrolimus 100 µM -0.864025650997992 0.160401790045117 no 2790 0.193786899806528 865 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_671 0560-0003 407 µM -0.865774586547904 0.159930241060269 no 2791 0.19330689411959 870 3238678
SGTC_406 estrone 100 µM -0.866139044316089 0.159832090023484 no 2792 0.193206957963327 874 5870 A steroid.
SGTC_2001 4023502 57.655 µM -0.866809274617843 0.159651695179782 no 2793 0.193023259777781 896 108941 YCR052W RSC6
SGTC_1444 4112-3581 28 µM -0.868295154057047 0.159252240805913 no 2794 0.192616387178469 901 2877249
SGTC_3320 9137005 35.139 µM -0.869208196735932 0.159007109180436 no 2795 0.19236663245084 880 4908713
SGTC_1291 0993-0025 5.79 µM -0.869676550221754 0.158881462687466 no 2796 0.192238595389137 901 4353356
SGTC_575 k072-0246 11.9 µM -0.870302480215817 0.158713644326178 no 2797 0.192067561944713 899 6796779
SGTC_2553 4-methylesculetin 85.09 µM -0.871080031578336 0.158505336599087 no 2798 0.191855228151627 881 5319502
SGTC_2451 5856223 45.7 µM -0.871427417178797 0.158412329207697 no 2799 0.191760410523473 890 2179896
SGTC_954 1189-0853 2.85 µM -0.872469499415911 0.158133541816615 no 2800 0.191476150174331 884 2828194
SGTC_8 0354-0001 70 µM -0.872790085026327 0.158047840628023 no 2801 0.191388752432556 888 4993152
SGTC_2665 lovastatin 100 µM -0.873474310345115 0.157865030729149 no 2802 0.191202301366987 893 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_2210 7115885 190.385 µM -0.873523518212064 0.157851888827964 no 2803 0.191188896540895 902 2927039
SGTC_2116 5511452 16.8835 µM -0.875511640746679 0.157321523640743 no 2804 0.190647789589097 909 870744
SGTC_108 0509-0257 621.132 µM -0.875962711911402 0.157201356038492 no 2805 0.190525152587672 890 536624
SGTC_433 pimozide 108 µM -0.875992403783839 0.15719344809373 no 2806 0.190517081675738 892 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_777 1315-0167 517 µM -0.877015451044156 0.156921135962864 no 2807 0.190239122889444 880 4221767
SGTC_1000 4048-0884 8.67 µM -0.877253441547309 0.156857832776678 no 2808 0.19017449734109 914 13040088
SGTC_1479 0549-0158 134 µM -0.877649427830381 0.156752541475479 no 2809 0.190066998450532 909 5440202
SGTC_1260 0700-1617 7.75 µM -0.878459159338543 0.156537381673578 no 2810 0.189847295917109 875 2853078
SGTC_17 0960-0276 49.807 µM -0.880332423106609 0.156040368378671 no 2811 0.189339626504129 891 6821114
SGTC_1645 Cervolide 78 µM -0.880376219696137 0.156028760747369 no 2812 0.189327767284998 897 23173 A fragrance.
SGTC_343 4130-2827 29.8 µM -0.880438386741792 0.15601228527852 no 2813 0.189310934507894 888 1118244
SGTC_1101 ebselen 5.29 µM -0.884648696938403 0.15489914007965 no 2814 0.188173066801769 887 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_1575 cyproterone acetate 48 µM -0.884654722942914 0.154897550659896 no 2815 0.188171441259714 912 9880 An androgen receptor antagonist and liver toxin.
SGTC_2242 6630449 61.2675 µM -0.884809743827272 0.154856666033812 no 2816 0.188129626651812 910 691249 YDR170C SEC7
SGTC_997 3996-0078 137 µM -0.889976727588631 0.153498023637123 no 2817 0.186739191218417 890 735687
SGTC_2884 9058502 51.95 µM -0.890440602617836 0.153376436506369 no 2818 0.186614674385171 889 6471554
SGTC_3152 9099253 49.47 µM -0.891738217799001 0.153036655171469 no 2819 0.186266631861571 876 25236131
SGTC_1289 0976-0073 69.1 µM -0.892353001865038 0.152875847923017 no 2820 0.186101876803799 904 3391136
SGTC_536 3852-0578 10.6 µM -0.892356342508922 0.152874974426869 no 2821 0.186100981796492 909 2869208
SGTC_2697 mebhydrolin 72.4 µM -0.8932095669768 0.152651985595075 no 2822 0.185872477863487 909 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_805 3852-0218 479 µM -0.894906925314389 0.152209025631173 no 2823 0.185418422211793 887 6615355
SGTC_1478 0453-0656 35.7 µM -0.895003930711371 0.152183735918787 no 2824 0.185392493381883 919 5258496
SGTC_367 0335-0881 7.1 µM -0.895762192103853 0.151986150149025 no 2825 0.185189893254637 906 23828853
SGTC_635 k038-0028 24.7 µM -0.896009906130802 0.151921638418841 no 2826 0.185123736266652 911 4035102
SGTC_3303 9125618 40.5795 µM -0.896556329373894 0.151779398699159 no 2827 0.18497785492006 884 22695467
SGTC_883 0850-0245 24.6 µM -0.898623000661004 0.151242222949851 no 2828 0.184426751577072 878 6823229 YPR165W RHO1
SGTC_340 k038-0059 454 µM -0.899089612928167 0.151121114822619 no 2829 0.184302465151608 892 23733424
SGTC_1049 3226-0134 66 µM -0.899366077130601 0.151049389631409 no 2830 0.184228850987573 895 5702385
SGTC_48 0382-0018 55 µM -0.900837689568431 0.150667979393332 no 2831 0.183837312536809 907 762596
SGTC_1682 st012968 530 nM -0.901003294523743 0.150625098339029 no 2832 0.183793284009798 902 24207270
SGTC_928 2764-0428 58.7 µM -0.902143505749056 0.150330077458278 no 2833 0.183490320318289 915 662578
SGTC_2327 6189656 200 µM -0.902971813683897 0.150116000773636 no 2834 0.183270427269964 923 5349088
SGTC_1648 st011736 69.8 µM -0.903257265447504 0.150042272702005 no 2835 0.183194685742376 916 2855514
SGTC_158 k038-0087 26.446 µM -0.903587107196897 0.149957109408546 no 2836 0.183107190131146 859 X158
SGTC_1650 st011916 45.8 µM -0.904172839007876 0.149805956191525 no 2837 0.182951879996634 923 242528
SGTC_878 0828-0289 13.7 µM -0.908560980996708 0.148676791156631 no 2838 0.181790955420383 900 745350 YLR208W SEC13
SGTC_1065 prochlorperazine maleate 2.48 µM -0.908985708464375 0.148567802259097 no 2839 0.181678834864959 913 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_256 clotrimazole 625 nM -0.909192678504908 0.148514711243389 no 2840 0.181624214110069 862 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_1609 st001574 46.4 µM -0.909386405461394 0.148465028779466 no 2841 0.181573097604116 905 3960012
SGTC_2702 st077768 96.8 µM -0.91123696567067 0.147991001498458 no 2842 0.181085265426701 881 6484119
SGTC_3085 9117376 49.47 µM -0.912684255515073 0.147620980008363 no 2843 0.180704313424711 896 16480349
SGTC_2067 5224629 34.075 µM -0.913802155277968 0.147335596603493 no 2844 0.180410406870432 908 2835000
SGTC_1392 3455-1037 33.9 µM -0.915810579769454 0.146823804735725 no 2845 0.179883126745881 875 981132
SGTC_840 0245-0196 390 µM -0.915843209141957 0.146815499892502 no 2846 0.179874568417434 895 3827528
SGTC_2424 5537928 59.2 µM -0.916587430561237 0.14662616586823 no 2847 0.1796794367001 903 5382802
SGTC_750 4073-0104 132 µM -0.917061118158829 0.146505742510456 no 2848 0.179555307107947 868 22330957
SGTC_2002 4023503 131 µM -0.917826544700997 0.146311292086403 no 2849 0.17935484141574 924 4736863 YCR052W RSC6
SGTC_2734 clemastine 41.6 µM -0.918152001584644 0.146228664929543 no 2850 0.179269646709016 944 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_2053 5265679 138 µM -0.920362891202771 0.145668192786855 no 2851 0.178691576942611 911 764595
SGTC_1207 2099-0101 141 µM -0.922055046645246 0.145240199445389 no 2852 0.178249931730798 896 5837381
SGTC_2464 5717415 7.67 µM -0.922736117266141 0.145068176723607 no 2853 0.178072369585565 900 5285744
SGTC_2218 6965428 192.983 µM -0.92449759851347 0.144623903421063 no 2854 0.177613650618855 895 675684
SGTC_2990 9074105 71.4286 µM -0.926014803700907 0.14424197583229 no 2855 0.177219143508813 917 6502001
SGTC_88 0180-0332 8.668 µM -0.927818600035075 0.143788789821781 no 2856 0.176750837026156 908 3101745
SGTC_1798 st045719 60.953 µM -0.928156024114688 0.143704122131816 no 2857 0.176663321013696 879 3980186
SGTC_1147 3809-1045 12.3 µM -0.928403732609096 0.143641987624606 no 2858 0.176599091531521 891 325925
SGTC_1907 st060210 83.7 µM -0.928913517696198 0.143514171617213 no 2859 0.176466953471754 913 688793
SGTC_1889 st059080 5.18 µM -0.930386832789845 0.143145205966002 no 2860 0.176085416775001 904 176925 Isolated from Daphnopsis sellowiana.
SGTC_336 4111-0029 111 µM -0.930843822885242 0.143030891216029 no 2861 0.175967178633506 922 3131175
SGTC_2170 morpholine 200 µM -0.931227821060784 0.142934882886831 no 2862 0.175867864745886 911 121171 Reacts with secondary amines.
SGTC_251 melphalan 456.522 µM -0.932324825254043 0.142660846708154 no 2863 0.17558434091343 919 460612 A DNA alkylator.
SGTC_2232 chlorophetanol 41.5365 µM -0.933314322103093 0.142413971216401 no 2864 0.175328851272727 910 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1169 aniline yellow 25.8 µM -0.934041541667144 0.142232717203146 no 2865 0.175141232393042 900 6051 A DNA damaging agent.
SGTC_3127 9126946 49.47 µM -0.937866425888188 0.141281963851694 no 2866 0.174156529525709 896 27243249
SGTC_1047 2043-3044 82 µM -0.940315362807517 0.140675497682661 no 2867 0.173527910819622 951 669592
SGTC_972 1319-0219 195 µM -0.940422836297825 0.140648922976248 no 2868 0.173500356518048 918 23903702
SGTC_3087 9117406 49.47 µM -0.941028953261749 0.140499113714688 no 2869 0.173345010991774 893 42546093
SGTC_1623 st003709 20.3 µM -0.941494769033204 0.140384055260438 no 2870 0.173225684336369 909 16192618
SGTC_2690 usnic acid 100 µM -0.946000617432009 0.139274394591864 no 2871 0.172074135653457 919 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2335 9018011 154.17 µM -0.946351913198152 0.139188132058586 no 2872 0.171984561643455 908 6458208
SGTC_1275 0867-0008 21.1 µM -0.94662779796907 0.139120412589573 no 2873 0.171914236933855 915 3422836
SGTC_1171 0368-0077 21.4 µM -0.947489181019683 0.138909119362254 no 2874 0.171694783323416 907 3239779
SGTC_2856 9022925 19.48 µM -0.949449337298053 0.138429116915534 no 2875 0.171196063747414 925 4944862
SGTC_365 0121-0052 13.6 µM -0.949860485786776 0.138328578594362 no 2876 0.17109157350675 883 3101739
SGTC_483 fpl-64176 144 µM -0.95085648648215 0.138085232475876 no 2877 0.17083861668922 925 3423
SGTC_3065 9113888 49.47 µM -0.950969758736429 0.138057575931401 no 2878 0.170809863812151 929 16648368
SGTC_441 propafenone 146 µM -0.951177696625267 0.138006815666391 no 2879 0.170757089198521 920 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_3109 9122853 49.47 µM -0.955814032273782 0.13687833306999 no 2880 0.169583098818736 952 1234709
SGTC_2880 9042983 58.44 µM -0.956155556323934 0.136795456347867 no 2881 0.16949682500626 930 6464714
SGTC_1671 st016596 74.5 µM -0.956381495172256 0.136740647232301 no 2882 0.169439765134407 914 2829167
SGTC_203 k066-0004 30.888 µM -0.956563922280164 0.136696404318279 no 2883 0.169393702958687 945 6795412
SGTC_163 TUB2.036 7.546 µM -0.959690921366533 0.135939554211181 no 2884 0.168605396894759 901 15992207 YJR013W GPI14
SGTC_1129 3453-1384 223 µM -0.960218798099924 0.13581207200152 no 2885 0.168472553945681 940 1084452
SGTC_3283 9109332 35.8195 µM -0.961606895263845 0.135477237392764 no 2886 0.168123553271964 890 17027281
SGTC_2492 derrusnin 100 µM -0.965277522426931 0.134594541928185 no 2887 0.167202913532674 937 1715307 Part of coumarin class of compounds.
SGTC_1611 st001856 99.4 µM -0.966026048824651 0.134415025422165 no 2888 0.167015573326107 936 647478
SGTC_3219 9131112 49.47 µM -0.966490879280212 0.134303629514607 no 2889 0.166899304324717 899 17612988 YMR079W SEC14
SGTC_806 3966-4455 5.86 µM -0.967012500170751 0.134178699376939 no 2890 0.166768892397468 921 714982
SGTC_244 nsc-207895 1.295 µM -0.969594316982991 0.133561520195799 no 2891 0.166124373382866 879 42640
SGTC_728 3030-5151 22.5 µM -0.970508325817118 0.133343496474012 no 2892 0.165896588447372 927 3125388
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM -0.970609405907972 0.133319400309993 no 2893 0.165871410150403 904 688667
SGTC_438 sphingosine 6.67 µM -0.970664421501988 0.13330628657514 no 2894 0.165857707214213 921 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_295 k015-0027 31 µM -0.971048198766204 0.133214832595089 no 2895 0.165762138756806 925 3887424
SGTC_866 0495-0101 262 µM -0.972603623054355 0.132844617701397 no 2896 0.165375170640764 904 635694
SGTC_1615 st002656 86.5 µM -0.974444880843403 0.132407286527604 no 2897 0.164917847184213 936 1584458
SGTC_601 0986-0029 62.9 µM -0.976263778252163 0.131976241515708 no 2898 0.164466882422343 902 24747981
SGTC_2776 terbinafine 19.92 µM -0.976815481628013 0.131845689539715 no 2899 0.164330255067653 896 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1917 st066507 28.5 µM -0.97859995118546 0.131424032955928 no 2900 0.163888841710193 922 3156428
SGTC_396 dithiazanine 1.25 µM -0.979468093978312 0.131219234416362 no 2901 0.163674372997571 916 10578 An antihelmenthic.
SGTC_1748 st037455 53.6035 µM -0.980571396196905 0.130959278982901 no 2902 0.163402072808768 926 580690
SGTC_1979 st071809 45.3 µM -0.98137880333816 0.130769266742484 no 2903 0.163202987494907 949 4976333
SGTC_106 0092-0003 11.579 µM -0.981548871185443 0.130729267907482 no 2904 0.163161073352654 920 1072148
SGTC_1108 betulinic acid 729.144 nM -0.981826246236083 0.130664049273693 no 2905 0.163092727779139 904 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_1995 st072814 61.1 µM -0.983367551085415 0.130302055186551 no 2906 0.162713287289437 933 5769371
SGTC_1788 fluconazole 20 µM -0.983464592404749 0.130279287097915 no 2907 0.16268941675709 903 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_3117 9124945 49.47 µM -0.985641823525891 0.129769182958417 no 2908 0.162154453443587 914 17592065
SGTC_2769 toremifene 3.73 µM -0.986045917755089 0.129674659980845 no 2909 0.162055290391182 933 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1026 k007-1105 30.6 µM -0.986925079606929 0.129469177173467 no 2910 0.16183968417753 913 7066794
SGTC_546 peri-Naphthalide 147 µM -0.988698287708294 0.129055419363184 no 2911 0.161405390416405 898 223824 A penicillin ester.
SGTC_787 4152-0075 138 µM -0.98894777607615 0.128997277767269 no 2912 0.161344346822395 912 9566539
SGTC_767 0929-0023 86 µM -0.990117755229736 0.128724864285409 no 2913 0.161058282946366 931 1204563
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.990151995217276 0.128716897993209 no 2914 0.161049916141137 934 616764
SGTC_3182 9108849 49.47 µM -0.991625916609368 0.128374298968022 no 2915 0.160690020988861 916 17133045
SGTC_1243 0416-0003 5.65 µM -0.993823567218123 0.127864652515694 no 2916 0.160154385205796 933 2141977
SGTC_1705 st027868 56.3335 µM -0.995365357925892 0.127507943612772 no 2917 0.159779300377052 901 292948
SGTC_2885 9057732 51.95 µM -0.99839941369804 0.126808006165953 no 2918 0.159042858908023 919 6471414
SGTC_1356 1502-0781 85.8 µM -1.00058218914106 0.126306111140837 no 2919 0.158514422210472 932 567702
SGTC_2989 9073649 71.4286 µM -1.00189611074704 0.12600466374563 no 2920 0.158196885610892 926 21367202
SGTC_1730 st033808 45.1 µM -1.00408738675266 0.125503045315771 no 2921 0.157668247261741 927 1045166
SGTC_1089 terbinafine 2.25 µM -1.00431583479266 0.125450830205169 no 2922 0.157613201778157 911 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1812 st052057 4.327 µM -1.0047540546311 0.125350711152738 no 2923 0.157507646272136 941 3645418
SGTC_1440 4100-1550 40 µM -1.00685602766692 0.124871253821856 no 2924 0.15700198283599 934 742806
SGTC_576 1073-0113 22.7 µM -1.00845483603794 0.124507426684553 no 2925 0.156618079574977 951 5439563
SGTC_59 0330-0160 1.33 µM -1.00985080775995 0.124190363951665 no 2926 0.156283386878796 936 4293482
SGTC_145 3737-0113 38.366 µM -1.01133720449465 0.123853384624265 no 2927 0.155927532528977 918 6849351
SGTC_399 oxolinic acid 75 µM -1.01771859553695 0.12241394098297 no 2928 0.154405853740028 916 4628 A DNA gyrase inhibitor.
SGTC_819 1013-0258 27.7 µM -1.02059862292363 0.121768156233589 no 2929 0.153722321087793 937 5753198
SGTC_2311 7694451 200 µM -1.02200240161305 0.121454257989207 no 2930 0.153389881868027 943 2163142
SGTC_72 0744-0168 198.391 µM -1.02465594899755 0.120862454541995 no 2931 0.152762777589906 961 677577
SGTC_444 curcumin 90.4 µM -1.02514014805701 0.120754686080649 no 2932 0.152648532098739 921 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_867 0518-0118 155 µM -1.02519886474611 0.120741622073543 no 2933 0.152634681905198 917 6848158
SGTC_2581 avocatin a 64 µM -1.02601193171176 0.120560823255384 no 2934 0.15244297997353 951 6710728 A skin care supplement.
SGTC_3146 9095609 49.47 µM -1.02603729690801 0.120555185954593 no 2935 0.152437002032376 946 17173999
SGTC_472 calcifediol 10 µM -1.02686891128943 0.120370466188206 no 2936 0.152241097525557 956 5283731 A vitamin D metabolite.
SGTC_2353 9059630 146.67 µM -1.0268726299735 0.120369640635019 no 2937 0.152240221885759 952 4779114
SGTC_1531 st059297 52.4 µM -1.02934295940396 0.119822105027028 no 2938 0.151659271443484 926 7566702
SGTC_1975 st070967 30.8 µM -1.02996161814158 0.119685257942433 no 2939 0.151514011716873 933 261391
SGTC_3120 9124077 49.47 µM -1.03018140320382 0.119636668112723 no 2940 0.151462428937311 967 18774327 YGL155W CDC43
SGTC_2808 7946468 45.46 µM -1.03083101721076 0.119493133533026 no 2941 0.151310035086373 944 2970879
SGTC_270 tamoxifen 5.46 µM -1.03758070716976 0.118008951232702 no 2942 0.149732651860307 970 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_1109 tnp00067 928.257 nM -1.03782398892515 0.117955700823378 no 2943 0.149676003182683 942 676295
SGTC_2358 9037157 4 µM -1.04155632080667 0.117140884425845 no 2944 0.148808714237532 929 2388925
SGTC_221 trifluoperazine 10.304 µM -1.04205895476419 0.117031458335435 no 2945 0.148692173361679 952 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_316 k060-0003 58.6 µM -1.04484753474422 0.116425685245343 no 2946 0.148046720658441 949 6152314
SGTC_1821 st053465 65.6 µM -1.04549393838426 0.116285582823418 no 2947 0.147897370340638 948 675086
SGTC_1235 benzylparaben 21.5 µM -1.04631527453154 0.116107737910519 no 2948 0.147707747754378 961 7180
SGTC_3210 9128157 49.47 µM -1.04650405457932 0.116066888437615 no 2949 0.147664186963981 946 17590849
SGTC_2447 5741742 33.78 µM -1.05133724834856 0.115024522280833 no 2950 0.146551862671955 941 1776504
SGTC_1094 duloxetine 25.4 µM -1.05271426845315 0.114728765130832 no 2951 0.146235983593899 930 60834 A selective serotonin reuptake inhibitor.
SGTC_779 1360-0071 233 µM -1.05474187628576 0.114294259969767 no 2952 0.145771696995722 929 7566
SGTC_2238 6671620 73.2395 µM -1.0564792901877 0.113922875030978 no 2953 0.14537464880806 926 729941
SGTC_2084 5306078 60.6385 µM -1.05726087871264 0.113756085479522 no 2954 0.145196271199237 957 679340
SGTC_682 0kpi-0099 17 µM -1.05879527352493 0.113429154847446 no 2955 0.144846513335641 942 1714895 YML126C ERG13
SGTC_2356 9061756 188.97 µM -1.05963263651701 0.11325102236536 no 2956 0.144655879970735 935 20104043
SGTC_419 nsc-638432 893 µM -1.06024280218156 0.113121347391962 no 2957 0.144517076648139 940 368090
SGTC_1074 carmofur 3.8 µM -1.06177557273255 0.1127960640085 no 2958 0.144168790841677 948 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2279 7948423 32.93 µM -1.06252606017089 0.112637039912591 no 2959 0.143998466892936 930 1247112
SGTC_1556 plumbagin 1.48 µM -1.06302626529212 0.112531138203947 no 2960 0.143885020191146 915 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_3036 9090181 49.47 µM -1.06304248020638 0.112527706428593 no 2961 0.143881343651929 952 25236586
SGTC_1767 st044992 70.3 µM -1.06415357929425 0.112292727972691 no 2962 0.143629566075947 944 9600693
SGTC_1696 st025591 34.7925 µM -1.06513697912436 0.112085048414336 no 2963 0.143406973637477 926 2787147
SGTC_2414 st077232 92.9 µM -1.06731856379474 0.111625310417564 no 2964 0.142914004057449 931 729801
SGTC_3259 9138485 49.47 µM -1.07256296238634 0.110525651709049 no 2965 0.141733625041888 941 17646153
SGTC_1344 1488-0097 29.1 µM -1.07270917431209 0.110495105291295 no 2966 0.141700811394268 959 747966
SGTC_261 5-fluorouridine 15.376 µM -1.07274266888158 0.110488108498663 no 2967 0.141693295091707 952 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1647 st011722 22.4 µM -1.07403057922078 0.110219313468808 no 2968 0.14140448817782 932 2854783
SGTC_2440 5628896 157.78 µM -1.07428571696462 0.110166120315524 no 2969 0.141347322300222 957 5522048
SGTC_363 0455-0021 3.06 µM -1.07438879330123 0.110144635361472 no 2970 0.141324231574712 919 4597466
SGTC_1031 k035-0009 16 µM -1.07501987024558 0.110013160913998 no 2971 0.141182916133345 956 5180959
SGTC_514 4466-0038 2.65 nM -1.07637723199645 0.109730758672714 no 2972 0.14087929034066 907 5722064
SGTC_168 3970-0862 530.542 µM -1.07858942987692 0.109271621649005 no 2973 0.140385397707515 935 3135186
SGTC_1509 1326-1131 80 µM -1.08657202773259 0.107626329462528 no 2974 0.138612996377886 911 768313
SGTC_332 4112-0506 40.9 µM -1.08776002211189 0.107383006104675 no 2975 0.138350531240487 946 2790355
SGTC_1581 himbacine 57.9 µM -1.09076655987897 0.10676898346248 no 2976 0.137687807163099 985 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2506 ethyl hematommate 54.16 µM -1.09255350695604 0.106405239374841 no 2977 0.137294942738323 952 3940691 An allergen.
SGTC_2648 atorvastatin 78.68 µM -1.09274937602082 0.106365423501518 no 2978 0.137251927076408 947 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_3330 9141424 71.43 µM -1.09711914723992 0.105479940934944 no 2979 0.136294655585774 935 27261020
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.0980038188374 0.105301323505001 no 2980 0.136101410865037 957 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1276 0871-0068 94.2 µM -1.09862882773345 0.105175264609151 no 2981 0.135964999102068 951 3414906
SGTC_951 1171-0579 82.7 µM -1.10148751214605 0.104600084596079 no 2982 0.135342268283738 939 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_1394 3474-0001 65.7 µM -1.10184038596282 0.104529243111014 no 2983 0.135265534638451 934 5017666 YIL048W NEO1
SGTC_1051 3253-3903 78 µM -1.10607044266901 0.103682738876968 no 2984 0.134348015417358 938 5509239
SGTC_2886 9058944 51.95 µM -1.10693930838409 0.103509481954173 no 2985 0.134160084668225 925 4949929
SGTC_2043 5101342 149 µM -1.11209677086584 0.10248537777909 no 2986 0.133048272493262 974 678451
SGTC_2056 5235370 200 µM -1.11213425056375 0.102477962590832 no 2987 0.133040216144798 974 5511916
SGTC_1481 3346-2004 36 µM -1.11401554853305 0.102106257378238 no 2988 0.132636258164726 964 2770522
SGTC_1028 k015-0029 4.8 µM -1.11588171277782 0.101738512340435 no 2989 0.132236385293438 967 4588309
SGTC_844 0330-0132 15.3 µM -1.11984787362762 0.100960147678036 no 2990 0.131389297240453 946 2828079
SGTC_54 0159-0055 9 µM -1.12387244110082 0.100174767425522 no 2991 0.13053357207263 958 3319099
SGTC_899 1083-0020 478 µM -1.1243444829825 0.100082943151036 no 2992 0.13043345709858 967 767123
SGTC_1700 st030840 7.9285 µM -1.12548421775004 0.0998614888090076 no 2993 0.13019195064694 960 5499307
SGTC_1380 2291-0730 164 µM -1.12733164150234 0.0995032887069088 no 2994 0.129801144568345 966 2999191
SGTC_1418 3966-3099 2.4 µM -1.12878108952045 0.0992229108828609 no 2995 0.129495095943351 939 740335
SGTC_2481 5478948 45.16 µM -1.13063741779917 0.0988646713860518 no 2996 0.129103865881836 961 77792
SGTC_501 nsc-95397 161 µM -1.13119129839478 0.0987579654726504 no 2997 0.128987291800778 955 262093
SGTC_214 4373-3496 70 µM -1.13222703412739 0.0985586556640065 no 2998 0.128769498605555 969 3779166
SGTC_724 3910-0327 137 µM -1.13242092241069 0.0985213778908732 no 2999 0.128728756389464 966 2885483
SGTC_1195 1502-0147 41.1 µM -1.13252566911103 0.0985012431469667 no 3000 0.128706749432212 938 817940
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.13326826917605 0.0983585845855807 no 3001 0.128550806311296 924 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2935 9038016 29.96 µM -1.13385701941931 0.098245589208214 no 3002 0.12842726428462 953 6463195
SGTC_2916 7875993 68.79 µM -1.13386383928083 0.098244280869551 no 3003 0.128425833703274 935 1299250
SGTC_675 1309-0189 238 µM -1.13943502635561 0.0971797499072557 no 3004 0.127260876875755 950 4246530
SGTC_1168 k815-0004 80.5 µM -1.13980498214264 0.0971093604021691 no 3005 0.127183778817505 970 642433
SGTC_1009 4106-0057 9.87 µM -1.14035473489699 0.0970048310193112 no 3006 0.127069271461182 960 2928005
SGTC_1458 k015-0034 6.33 µM -1.14191772707482 0.0967080966702447 no 3007 0.126744109670956 977 3598957
SGTC_2195 6536160 144.242 µM -1.14292775366937 0.0965166978607789 no 3008 0.126534294173366 959 3834386
SGTC_122 0236-0016 402.397 µM -1.14381160863232 0.096349436875097 no 3009 0.126350887243796 956 6808838
SGTC_693 4161-2696 114 µM -1.14495493658871 0.0961333892712242 no 3010 0.126113912517592 981 805759
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM -1.14558963654462 0.0960136077953716 no 3011 0.125982493668534 960 165521
SGTC_828 2074-0507 139 µM -1.14578779707098 0.0959762331500297 no 3012 0.125941482780601 957 X828
SGTC_1417 3966-0327 90.4 µM -1.14689073665948 0.0957684054837232 no 3013 0.125713390822438 987 651118
SGTC_1227 3909-8010 46.6 µM -1.15159016035542 0.0948865997755562 no 3014 0.124744763323463 961 15982272
SGTC_38 0929-0051 58.268 µM -1.1534655611787 0.0945363722697163 no 3015 0.124359672593809 965 1379719
SGTC_816 0325-0417 81.3 µM -1.15501718725961 0.0942473302426146 no 3016 0.124041694125866 948 68101
SGTC_1038 k292-0204 154 µM -1.15545075372014 0.0941666806914386 no 3017 0.123952944092699 954 4454212
SGTC_2727 riluzole 51.77 µM -1.15552390659363 0.0941530782338225 no 3018 0.12393797425449 967 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_3106 9121286 49.47 µM -1.15900950018514 0.0935066262106746 no 3019 0.123226156323796 938 15943471
SGTC_2477 5967686 25.23 µM -1.16007765736591 0.0933091792579442 no 3020 0.123008594945598 984 776118
SGTC_3317 9138495 8.753 µM -1.16124245725109 0.0930942193523684 no 3021 0.122771656548148 962 17020139
SGTC_2534 helenine 20.12 µM -1.16184543309965 0.0929830860621399 no 3022 0.122649127706098 955 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1789 tunicamycin 25 nM -1.16274652893818 0.0928171896999707 no 3023 0.122466178760898 944 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_460 trequinsin 123 µM -1.16344926178173 0.0926879649558389 no 3024 0.12232363630191 1014 5537 A vasodilator.
SGTC_2178 5812956 200 µM -1.16747872632869 0.0919495594261216 no 3025 0.121508547287156 952 5403383
SGTC_2035 5154463 94.595 µM -1.16976547967677 0.0915324507790797 no 3026 0.121047679560278 974 2769623
SGTC_2700 st077718 96.8 µM -1.17105468441054 0.0912979160820621 no 3027 0.120788398555488 967 904970
SGTC_1879 gemcitabine 100 µM -1.17339281114131 0.0908736966673133 no 3028 0.120319159364792 986 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2639 lactacystin 53 µM -1.17339420504943 0.0908734441997084 no 3029 0.120318880004592 941 3870 A proteasome inhibitor.
SGTC_1769 st044406 64.4 µM -1.17676856128077 0.0902637979905618 no 3030 0.119643947051102 983 670903
SGTC_625 k213-0058 121 µM -1.17750237782412 0.0901316221460155 no 3031 0.119497524507643 973 3655420
SGTC_1905 st060207 84.5 µM -1.17837545073221 0.0899745506632876 no 3032 0.11932348009652 962 1948547
SGTC_527 4476-4215 268 µM -1.18187668344747 0.0893466993692557 no 3033 0.118627317471213 939 4418754
SGTC_2089 5281248 129.67 µM -1.1827934499271 0.0891828418274548 no 3034 0.118445508566983 963 2737878
SGTC_488 nitrendipine 139 µM -1.18344861314544 0.0890658788181424 no 3035 0.118315700340654 1003 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1256 0570-0116 285 µM -1.18533381711777 0.0887299597393803 no 3036 0.117942743929231 977 410638
SGTC_1947 st076332 61.6 µM -1.1901570360961 0.0878748204632665 no 3037 0.116992338094636 960 24208416
SGTC_3101 9120531 49.47 µM -1.193636612437 0.0872617313903368 no 3038 0.116310072864063 988 24824904
SGTC_2975 9084847 53.72 µM -1.19487022566685 0.0870451416632461 no 3039 0.116068868729412 976 27211724
SGTC_708 3448-5400 146 µM -1.19948559840705 0.0862383655488934 no 3040 0.115169590669684 981 3462195
SGTC_3137 9097352 49.47 µM -1.20058742103706 0.08604659438682 no 3041 0.114955641448929 942 44120435
SGTC_317 4495-0002 170 µM -1.20155199292661 0.0858789736619752 no 3042 0.114768575424084 963 15991618
SGTC_2544 sphondin 68.51 µM -1.20406173274282 0.0854439830759355 no 3043 0.114282859576444 952 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_60 0986-0278 202 µM -1.20488199450127 0.0853021729043631 no 3044 0.114124430226661 967 3110598
SGTC_1211 1056-0033 32.3 µM -1.20701842761512 0.0849336454842231 no 3045 0.113712523659209 957 6741922
SGTC_1004 4084-0029 199 µM -1.20725214927193 0.0848934018343412 no 3046 0.113667526265431 976 716894 YLR208W SEC13
SGTC_1086 cerivastatin 2.18 µM -1.21054477941394 0.0843279746370137 no 3047 0.113034959428324 943 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_2354 9060492 162 µM -1.21069686489863 0.0843019261926348 no 3048 0.113005802200298 993 6471895
SGTC_2927 9011802 47.9 µM -1.21402390441556 0.083733597327082 no 3049 0.112369298019793 969 43912568
SGTC_2285 7945142 200 µM -1.21435073235295 0.0836779238177026 no 3050 0.112306910210405 966 2970608
SGTC_47 0149-0135 24.25 µM -1.21715097143429 0.0832020564459127 no 3051 0.111773390169628 984 5239155
SGTC_2171 5739187 198.077 µM -1.21992797764251 0.0827321496189211 no 3052 0.111246089392685 959 2262761
SGTC_341 1486-1430 230 µM -1.22586439291872 0.0817343302234697 no 3053 0.110124855109914 982 2054753 YPL210C SRP72
SGTC_3203 9113543 49.47 µM -1.22596593365332 0.0817173420632967 no 3054 0.11010574748401 972 17018012
SGTC_3103 9120822 49.47 µM -1.23136232299645 0.0808183299006789 no 3055 0.109093690978489 978 17141819
SGTC_2749 bexarotene 57.39 µM -1.23191553795941 0.0807265906523165 no 3056 0.108990318279598 973 82146 An retinoic acid receptor inhibitor.
SGTC_1204 4049-0315 18.3 µM -1.23368443391355 0.0804337835742173 no 3057 0.10866025826243 974 588402
SGTC_2488 5268135 45.7 µM -1.23421945000457 0.0803453800767217 no 3058 0.108560570831649 982 1270356 YLR208W SEC13
SGTC_2421 5690543 90.72 µM -1.23572038147528 0.0800977652588603 no 3059 0.108281259415982 991 3397993
SGTC_2912 7964298 10.93 µM -1.23816082425089 0.0796963876108188 no 3060 0.107828217188718 965 2975850
SGTC_613 3914-0030 117 µM -1.2387568364761 0.0795985935326731 no 3061 0.107717781591947 943 1145395
SGTC_3166 9102297 49.47 µM -1.23989160310118 0.0794126513180593 no 3062 0.107507745049597 974 25237072
SGTC_36 0335-0881 14.2 µM -1.24176639398994 0.0791061696684633 no 3063 0.10716138264113 948 23828853
SGTC_1819 st053448 58.6 µM -1.24199453718898 0.0790689351489267 no 3064 0.107119288800767 997 2857616
SGTC_1860 st056228 74.6 µM -1.24692394262577 0.0782676606651354 no 3065 0.106212693385781 999 688679
SGTC_707 0865-0008 204 µM -1.24956978857372 0.0778401260804661 no 3066 0.105728372519898 998 723043
SGTC_3044 9093193 49.47 µM -1.25688878162133 0.0766667046611642 no 3067 0.104396955669148 973 25236277
SGTC_967 1306-0166 352 µM -1.25862712518282 0.0763899909447568 no 3068 0.104082522370074 987 4437607
SGTC_533 1222-0222 6.71 µM -1.26140712467654 0.0759490442083261 no 3069 0.103581101352293 991 3982874
SGTC_1731 st035964 63 µM -1.26353113833695 0.0756134540786877 no 3070 0.103199181705332 994 6739575
SGTC_3159 9100096 49.47 µM -1.26450540314353 0.0754599005593375 no 3071 0.103024341308777 992 25236875
SGTC_1627 st003713 25.6 µM -1.26798837860253 0.0749128930714411 no 3072 0.102401050372711 994 16195070 YER133W GLC7
SGTC_92 0063-0024 660.874 µM -1.27287197352127 0.074151016493153 no 3073 0.101531737974624 1021 3594437
SGTC_3232 9132874 49.47 µM -1.28171230599237 0.0727869334063412 no 3074 0.0999717932250209 978 3784940
SGTC_1557 sumaresinolic acid 42.3 µM -1.28281264563444 0.0726185018714932 no 3075 0.0997788613499867 978 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_2117 5521686 200 µM -1.283522600605 0.0725099859599494 no 3076 0.0996545233763011 1000 803312
SGTC_3201 9113999 49.47 µM -1.28575263974882 0.0721699345124187 no 3077 0.0992647018102278 983 16649224
SGTC_1540 guanosine 70.6 µM -1.28721879584449 0.0719470319915476 no 3078 0.0990090188786138 980 6802 Guanosine is a purine nucleoside
SGTC_2531 methyl deoxycholate 70.07 µM -1.28723262465461 0.0719449320869257 no 3079 0.0990066095682331 1006 16667744 Haematoxylin.
SGTC_1387 3342-1166 1.8 µM -1.28839135569104 0.0717691456877356 no 3080 0.098804883154117 966 3418228
SGTC_698 k064-0052 127 µM -1.29043830814191 0.0714594160874702 no 3081 0.0984492592814796 1032 5088751
SGTC_1901 st060216 58.6 µM -1.29110565729534 0.0713586598300029 no 3082 0.0983335213179422 982 688792
SGTC_1816 st051957 91.6 µM -1.29549034516591 0.0706993702816351 no 3083 0.0975755649160373 1016 674121
SGTC_673 1082-0474 110 µM -1.29973942462887 0.070064946750297 no 3084 0.0968451465837321 981 3098046
SGTC_1062 mesoridazine 14.2 µM -1.3003388274137 0.069975804444005 no 3085 0.0967424329959825 971 4078 A neuroleptic.
SGTC_369 0957-0393 4.5 µM -1.30222446570283 0.069695944087254 no 3086 0.0964198319960904 992 6997992
SGTC_2675 theaflavin digallate 100 µM -1.30312705364209 0.0695622901858422 no 3087 0.0962656944210379 1011 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_486 niguldipine 82 µM -1.30873323588614 0.0687365504388901 no 3088 0.0953123646684934 994 1236 A calcium channel blocker.
SGTC_2664 lyso-paf C-16 73.48 µM -1.3106123292902 0.0684614748358819 no 3089 0.0949943858153793 993 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_2561 acetosyringone 100 µM -1.31470408661335 0.0678654318844024 no 3090 0.094304686308209 996 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_1122 capsaicin 818.572 nM -1.3149778086981 0.0678257024758027 no 3091 0.0942586803270752 1002 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1114 scopoletin 1.73284 µM -1.31513100821101 0.0678034741649561 no 3092 0.094232938466146 1009 5280460 A coumarin with genotoxic properties.
SGTC_2483 5729050 27.16 µM -1.317219163321 0.0675010563740522 no 3093 0.0938825861014602 1005 2865180
SGTC_1465 k213-0056 144 µM -1.32066105494983 0.0670048596279342 no 3094 0.093307202577031 947 24048857 YMR208W ERG12
SGTC_924 2046-0044 21.3 µM -1.32188496368199 0.0668290976493477 no 3095 0.0931032300678534 989 3623589
SGTC_1526 st051518 75 µM -1.32298111949562 0.0666719848888927 no 3096 0.0929208283396003 989 673993
SGTC_1762 st045503 25.4615 µM -1.32366246697806 0.0665744710470522 no 3097 0.0928075844705666 1015 4645554
SGTC_1485 3909-9022 254 µM -1.33050221636828 0.0656016791679894 no 3098 0.0916764282973638 1020 714516
SGTC_268 camptothecin 39.6153 µM -1.3375848081113 0.0646060015626492 no 3099 0.0905159097181723 1021 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1986 st071812 45 µM -1.34039969127379 0.0642135576877912 no 3100 0.0900577180250043 1015 11838594
SGTC_2529 gangaleoidin 93.61 µM -1.34215909413674 0.0639692088005072 no 3101 0.0897722082938122 1012 4565183
SGTC_420 mitomycin C 81.9 mM -1.34235642828799 0.0639418478508872 no 3102 0.0897402276125361 963 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2307 7538926 6.34 µM -1.34488534576101 0.0635920112566739 no 3103 0.0893311316518417 985 96582
SGTC_2949 9072542 2.23 µM -1.34552467983819 0.0635038055660874 no 3104 0.0892279284015522 1011 16457352
SGTC_205 1486-1330 71.903 µM -1.34628025458816 0.0633996855277814 no 3105 0.0891060756357356 1011 4118834
SGTC_1749 st037932 54.2 µM -1.34702080077229 0.0632977654539506 no 3106 0.0889867667672358 1011 594497
SGTC_285 1486-1325 46 µM -1.34960157795998 0.0629435742402017 no 3107 0.0885719088762639 992 22310230
SGTC_1017 4239-0030 168 µM -1.35023847473949 0.0628564031782231 no 3108 0.0884697502215939 993 1149593
SGTC_3122 9126309 49.47 µM -1.35133091228815 0.0627071020381602 no 3109 0.0882947270060595 1031 17591206
SGTC_480 am 92016 50 µM -1.35269054180322 0.0625216705484814 no 3110 0.0880772566485841 1021 2129 K+ channel blocker.
SGTC_1210 3013-0140 750 nM -1.35388194572388 0.062359533981055 no 3111 0.0878870221825411 1006 905973
SGTC_3348 9149464 3.537 µM -1.35391867155983 0.0623545412255905 no 3112 0.0878811629482486 988 1951442
SGTC_2686 alizarin 95.37 µM -1.35658601120105 0.0619927580511683 no 3113 0.0874563945283584 974 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_834 0312-0008 75.7 µM -1.36457219158499 0.0609193460751718 no 3114 0.0861937749678435 1017 6385573 YIL048W NEO1
SGTC_1626 st003712 1.76 µM -1.36559525986044 0.0607828932431329 no 3115 0.0860330175962647 1002 24207035
SGTC_2677 mitomycin C 100 µM -1.37051243622144 0.0601303919426216 no 3116 0.085263498004257 1035 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1006 4099-6547 255 µM -1.37075549179003 0.0600982816589607 no 3117 0.0852255949069525 1016 3146833
SGTC_703 3875-0075 71.8 µM -1.37674172586281 0.0593116646732345 no 3118 0.0842960566524046 1044 2850814
SGTC_589 1227-0070 34.1 µM -1.3781675064353 0.0591255065263895 no 3119 0.0840757885072171 1012 2841384
SGTC_2549 cedrol 20.94 µM -1.38819384464841 0.057829323193428 no 3120 0.0825390130641746 984 6708665 A sedative which affects the nervous system.
SGTC_2365 9042475 200 µM -1.3898616304396 0.0576158989907761 no 3121 0.0822854494591887 989 6464479
SGTC_1773 st048542 73.5835 µM -1.39708937937412 0.0566981253856782 no 3122 0.0811933475871953 1003 3237138
SGTC_2751 anetholtrithion 17.25 µM -1.39774294243485 0.0566157074999969 no 3123 0.0810951369485812 1015 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1348 1493-0373 93.8 µM -1.40085162868527 0.056224976663417 no 3124 0.0806292230293967 1016 3010129
SGTC_301 4119-0100 24.5 µM -1.40207106912164 0.0560722869833874 no 3125 0.0804470126511231 1012 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_640 3381-0960 37.1 µM -1.40209260073397 0.0560695938886393 no 3126 0.0804437981668656 1014 1745025
SGTC_3331 9141060 1.957 µM -1.40427394973805 0.0557972870477918 no 3127 0.0801186442109895 1003 4906567 YPR165W RHO1
SGTC_269 exalamide 29 µM -1.41718104088428 0.0542073357030188 no 3128 0.0782150016878327 1020 3316 A derivative of salicylamide.
SGTC_827 3253-0474 693 µM -1.41725341310977 0.0541985227338141 no 3129 0.0782044252177228 1010 5402065
SGTC_2604 4'-hydroxychalcone 11.32 µM -1.42364676433692 0.0534244504570776 no 3130 0.0772743756983824 1021 5282362
SGTC_1674 st016616 23.6 µM -1.42420181218451 0.0533576636960886 no 3131 0.0771940302363933 1003 625830
SGTC_1032 k061-1018 98.7 µM -1.42800870612679 0.052901376482567 no 3132 0.0766446763238063 1021 4005393
SGTC_1161 k007-0610 110 µM -1.42847001664783 0.0528462955410328 no 3133 0.0765783093840679 991 5843850
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -1.42888624287817 0.0527966367607517 no 3134 0.0765184660642454 993 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_1632 st005650 90 µM -1.42972225867242 0.0526970059277993 no 3135 0.0763983745966876 1004 2759605
SGTC_1642 st009582 77.7 µM -1.43066275142703 0.0525851025986425 no 3136 0.0762634467523022 1009 6739311
SGTC_907 3448-6986 75.5 µM -1.43400796867396 0.0521886039018195 no 3137 0.0757849944221079 1011 590582
SGTC_1915 st067105 30.6 µM -1.43456953737619 0.0521222761898159 no 3138 0.075704900218368 999 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2759 disulfiram 3.38 µM -1.43486580499205 0.0520873105735521 no 3139 0.0756626707944983 985 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_788 1182-0090 188 µM -1.43527356988351 0.052039216480594 no 3140 0.0756045781106708 1015 5715185
SGTC_3184 9108758 49.47 µM -1.43535810284065 0.0520292506027248 no 3141 0.075592539281675 1022 902885
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM -1.44299211120336 0.051135485414034 no 3142 0.0745113467548923 1008 6312947
SGTC_1713 st033146 12.748 µM -1.44637709374782 0.0507431123093606 no 3143 0.0740357315120124 1028 674619
SGTC_2455 5377712 9.75 µM -1.45200115851607 0.0500964988853363 no 3144 0.0732506415559876 991 2243908
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.45297304257503 0.0499854274579589 no 3145 0.0731156194330962 1023 688751
SGTC_2836 9010338 19.48 µM -1.45785793803844 0.0494301298587079 no 3146 0.0724398522462035 1013 2994051
SGTC_2655 perillic acid 100 µM -1.45786936784046 0.0494288363577922 no 3147 0.0724382766993709 1030 5702197 An apoptosis inducer.
SGTC_1704 st028805 70.8 µM -1.46273765578271 0.0488803484836175 no 3148 0.0717695890801444 1011 2876101
SGTC_179 1273-0063 6.77 µM -1.46387976517377 0.0487523791249652 no 3149 0.0716134015326948 1032 3108139
SGTC_2141 5621638 7.665 µM -1.46469466585029 0.0486612361532637 no 3150 0.071502120457436 1025 2856238
SGTC_1594 piperine 70.1 µM -1.46499665276616 0.048627494887972 no 3151 0.0714609154923929 1020 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3072 9116419 49.47 µM -1.47539543691156 0.0474769971445163 no 3152 0.0700531307207545 1013 17170162
SGTC_904 1141-0088 396 µM -1.47811520222703 0.0471797142864445 no 3153 0.0696884728519385 1031 1378119
SGTC_2908 7930301 100 µM -1.48005863595285 0.0469682035267343 no 3154 0.0694287995666279 1015 2223178
SGTC_2277 7947813 106.88 µM -1.48015592960682 0.0469576347337449 no 3155 0.0694158192195708 1025 1246798
SGTC_902 1120-0002 2.07 µM -1.48352383431204 0.0465929609105427 no 3156 0.0689676443926846 964 3280475
SGTC_1992 st073643 23.3 µM -1.48466461343246 0.0464699548580897 no 3157 0.0688163450242916 1025 3161292
SGTC_1625 st003711 30.1 µM -1.48659094341517 0.0462628375350597 no 3158 0.0685614406138954 1018 24207034 YER133W GLC7
SGTC_1024 4507-0395 26 µM -1.48800696230902 0.0461110616387828 no 3159 0.068374528767185 1026 4201836
SGTC_2872 9044037 25.97 µM -1.49000849928062 0.0458972095060105 no 3160 0.0681110005867231 1033 6465195
SGTC_696 1560-0013 611 µM -1.49172990693879 0.0457139255895493 no 3161 0.0678849827842042 1018 1650269
SGTC_2315 7733312 200 µM -1.4921156999299 0.0456729297527459 no 3162 0.0678344083810467 1014 726316
SGTC_3023 9089636 49.47 µM -1.49385221066667 0.045488767254105 no 3163 0.0676071257915307 1054 17249241
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM -1.49838108288128 0.0450112744797512 no 3164 0.0670171342248879 992 6708739 YPR165W RHO1
SGTC_1142 3253-1408 9.78 µM -1.49983949499585 0.0448583712261958 no 3165 0.0668279919936591 1038 256655
SGTC_2274 7947094 46.08 µM -1.50363536817415 0.0444623632926706 no 3166 0.0663376395950096 1030 2971028
SGTC_176 1486-1328 72.834 µM -1.50506351439994 0.0443141018312998 no 3167 0.0661538740946827 1007 22310231
SGTC_1310 1188-0297 994 nM -1.50651018215086 0.0441643240627622 no 3168 0.0659681276303244 987 1588352
SGTC_1093 fluphenazine 7.97 µM -1.50941831871982 0.0438644709772434 no 3169 0.0655959573001974 1039 6602611 An atypical antipsychotic.
SGTC_2293 7624732 200 µM -1.51562124121625 0.0432303845811636 no 3170 0.0648075764234638 1009 894453
SGTC_2726 cimetidine 79.27 µM -1.51776990057852 0.0430124743771418 no 3171 0.0645362077367806 1032 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2441 5730946 39.09 µM -1.52767711026529 0.0420191700018715 no 3172 0.0632963629918355 1005 1774275
SGTC_1781 st038725 66.3 µM -1.52955211368731 0.0418332867516305 no 3173 0.0630638151186275 1027 4270275 YIL048W NEO1
SGTC_2104 5389443 200 µM -1.53679750040098 0.0411212457152846 no 3174 0.0621714528717465 1042 2244536
SGTC_144 4161-2749 112.381 µM -1.5486765364927 0.0399751232048169 no 3175 0.0607297485069366 1009 797501 YMR168C CEP3
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM -1.55296164402491 0.0395681101569964 no 3176 0.0602161491284995 1012 688664
SGTC_2260 7964312 200 µM -1.56188873163278 0.0387310104934649 no 3177 0.059157101756325 1034 231951
SGTC_1228 0124-0032 52.5 µM -1.56977195905032 0.0380038424944726 no 3178 0.0582340866871496 1023 X1228
SGTC_3028 9087778 49.47 µM -1.57655185172922 0.0373873927997488 no 3179 0.0574493394673105 1025 17217395
SGTC_1215 3852-0577 11.2 µM -1.57772519644221 0.0372815421429826 no 3180 0.0573143776007678 1020 2884876
SGTC_1861 st057647 17.4 µM -1.578118223533 0.0372461408752973 no 3181 0.0572692261885481 1030 688668
SGTC_1910 st062352 60.4 µM -1.58596582845771 0.0365450116503207 no 3182 0.0563735307021795 1027 2245730
SGTC_357 1325-0123 420 µM -1.58649292682742 0.0364983086899812 no 3183 0.056313767695268 1043 1098503
SGTC_1255 0566-0045 221 µM -1.5866391847964 0.0364853583257025 no 3184 0.0562971936569099 1020 2788469
SGTC_3326 9140064 16.379 µM -1.58935015738033 0.0362459961434946 no 3185 0.0559906803617993 1031 1868434
SGTC_2996 9066192 71.4286 µM -1.59789718756797 0.0354997493568181 no 3186 0.0550329300553684 1017 6472854
SGTC_355 1311-2252 105 µM -1.59960703412539 0.0353519840430093 no 3187 0.0548428935070299 1047 5338538
SGTC_1433 4060-0023 7.6 µM -1.60002076565141 0.035316305172492 no 3188 0.0547969883944353 1038 3840627
SGTC_233 rapamycin 362 pM -1.60302568165689 0.0350580562444604 no 3189 0.0544644921275609 1050 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_2505 galangin 7.89 µM -1.60494824324637 0.0348936415876799 no 3190 0.0542525976595844 1034 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2907 7721985 69.9 µM -1.61426182057938 0.0341060950660335 no 3191 0.0532353238628203 1041 3267881
SGTC_2302 7771753 200 µM -1.6212696447444 0.0335232053469315 no 3192 0.0524799110780136 1012 2203047
SGTC_297 0986-0032 24 µM -1.62456397373162 0.0332520401779878 no 3193 0.0521277493582654 1028 2847425
SGTC_3112 9123419 49.47 µM -1.62980463581969 0.0328243918580716 no 3194 0.0515713968541619 1049 17015854
SGTC_2781 5567276 71.43 µM -1.63254137232938 0.032602877089872 no 3195 0.0512827451645159 1021 2853274
SGTC_837 0091-0265 12.5 µM -1.63529128540813 0.0323815390772446 no 3196 0.0509939997762171 1052 759367
SGTC_3346 9158254 43.5805 µM -1.6361860244186 0.0323097902389487 no 3197 0.0509003302305887 1033 17639500
SGTC_1340 1486-1359 257 µM -1.63964894693749 0.0320333350088669 no 3198 0.0505390898420936 1025 4309068
SGTC_906 1165-0455 526 µM -1.65281439440793 0.0310000703077926 no 3199 0.0491843218150885 1034 3252859
SGTC_445 e6 berbamine 66 µM -1.67293709617281 0.0294741876458401 no 3200 0.047169840009624 1028 6610268 A calcium/calmodulin antagonist.
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -1.67556633242049 0.0292795009773172 no 3201 0.0469115840285823 1041 16725076
SGTC_2570 licareol 100 µM -1.67599550854368 0.0292478234593752 no 3202 0.0468695361888127 1035 443158
SGTC_2821 7996764 71.43 µM -1.6800195280964 0.0289521927465563 no 3203 0.0464767581573491 1008 2987135
SGTC_2417 cerulenin 830 nM -1.68339621701071 0.0287060394307842 no 3204 0.04614920755694 1037 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_3013 9080133 71.4286 µM -1.68585199654504 0.0285281135636731 no 3205 0.0459121549095949 1041 17050193
SGTC_2600 tangeritin 87.95 µM -1.68674700122456 0.0284634973011635 no 3206 0.045826005123922 1030 68077 A bioactive flavone.
SGTC_1435 4092-0789 56.7 µM -1.69602404893967 0.027800870870463 no 3207 0.0449406628828905 1035 2248285
SGTC_171 k064-0041 9.68 µM -1.69659479856482 0.0277605274695465 no 3208 0.0448866469373713 1008 53325
SGTC_172 1112-0046 2.638 µM -1.69959530017973 0.0275492387334291 no 3209 0.0446035374982269 1057 2802135 YIL048W NEO1
SGTC_504 lovastatin 124 µM -1.7008306756043 0.0274626367649514 no 3210 0.044487393628917 1051 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_2710 st078562 53.7235 µM -1.70732638626833 0.0270110025600186 no 3211 0.0438807021836559 1046 17250908
SGTC_274 sirtinol 40.1 µM -1.71265583723787 0.0266451010285353 no 3212 0.0433879371540874 1033 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_170 4197-0004 226 µM -1.71343773291962 0.0265917686775247 no 3213 0.0433160197565142 1042 218692
SGTC_780 0109-0199 192 µM -1.71393698839108 0.0265577616152212 no 3214 0.0432701494847395 1033 610414
SGTC_2120 5538279 151.968 µM -1.71398013347249 0.0265548244705851 no 3215 0.043266187270916 1050 2058197
SGTC_1139 k015-0024 46.9 µM -1.71741557685751 0.0263218228166007 no 3216 0.0429516337836694 1053 2766652
SGTC_2111 5486399 200 µM -1.71840078055778 0.0262553196423656 no 3217 0.0428617690381339 1031 689674
SGTC_309 k408-0051 1.48 µM -1.72309318416362 0.0259404980882832 no 3218 0.0424358375943237 1023 3640463
SGTC_529 4076-0302 30.3 µM -1.73344154333545 0.025257359501699 no 3219 0.0415086095442219 1048 5816522
SGTC_1064 honokiol 6.76 µM -1.74196216952974 0.0247062524325725 no 3220 0.0407575320613727 1056 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_1149 3909-7961 23.3 µM -1.74508936013867 0.0245065353213598 no 3221 0.0404846576758201 1048 735261
SGTC_2513 baicalein 25.65 µM -1.74626117676645 0.0244320474305313 no 3222 0.0403827893547406 1059 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2720 fluspirilene 36.88 µM -1.74768638255755 0.0243417088022175 no 3223 0.040259174039863 1042 3396 An atypical antipsychotic.
SGTC_481 bay k-8644 50 µM -1.75139132320338 0.0241081774202373 no 3224 0.0399392632855219 1049 2303 A calcium channel antagonist.
SGTC_948 3448-0295 75.3 µM -1.75735029286621 0.0237365185307211 no 3225 0.0394290601533783 1025 678569
SGTC_1390 3413-2614 145 µM -1.75993587621701 0.0235767616744113 no 3226 0.0392093397752438 1059 3421432
SGTC_391 gliotoxin 8.33 µM -1.761109941715 0.0235045181688743 no 3227 0.0391098983360416 1046 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_1059 3448-6867 171 µM -1.76556292470215 0.0232322041834231 no 3228 0.0387346023517828 1043 3934407
SGTC_2331 7980721 200 µM -1.76616952754566 0.023195314846985 no 3229 0.0386837058589623 1027 2981221
SGTC_418 lividomycin a 100 µM -1.7695094445893 0.0229930865869641 no 3230 0.0384044480284508 1053 72394 An antibiotic.
SGTC_2010 4012422 159 µM -1.77038745290026 0.0229401713404516 no 3231 0.038331309240638 1042 952393
SGTC_1978 st071761 42 µM -1.77183581292497 0.0228531066875561 no 3232 0.0382109079053379 1047 5147680
SGTC_2319 6033012 152.6 µM -1.77350691399459 0.0227529985797019 no 3233 0.0380723736195323 1050 847246
SGTC_2691 st077356 60.2 µM -1.77509391784032 0.0226582707377989 no 3234 0.0379411905463171 1054 2839272
SGTC_1085 doxorubicin 7.67 µM -1.77588413303313 0.0226112271112098 no 3235 0.037876008361839 1032 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_730 1436-0052 41.2 µM -1.77633987326131 0.0225841331317834 no 3236 0.0378384574547881 1048 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_2563 tomatine 8.54 µM -1.78124650489027 0.0222941611700756 no 3237 0.0374360947246063 1049 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_711 k292-0785 179 µM -1.80302351549977 0.0210448111983469 no 3238 0.0356922608319922 1040 4146315
SGTC_2526 patulin 37.61 µM -1.8032140223734 0.0210341487127481 no 3239 0.0356773045546815 1043 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1325 1431-0015 227 µM -1.80390934766546 0.0209952708109579 no 3240 0.0356227596708901 1054 1103340
SGTC_2611 pyromycin 23.93 µM -1.8047255708966 0.0209497107202716 no 3241 0.0355588181667501 1058 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_3163 9099914 49.47 µM -1.80980189552821 0.0206682341181945 no 3242 0.0351632569413227 1070 16268368
SGTC_3083 9117465 49.47 µM -1.81347440596177 0.0204666000500342 no 3243 0.0348793413149861 1046 16420915
SGTC_2022 5136654 200 µM -1.82520696260319 0.0198335739329777 no 3244 0.0339849017583837 1048 1713771
SGTC_2979 9012552 45.46 µM -1.84722151339662 0.0186905716013815 no 3245 0.0323575213222348 1060 17100905
SGTC_1835 st008666 49.2 µM -1.85731038510556 0.0181857842359538 no 3246 0.0316335038773339 1050 690455
SGTC_729 4092-0585 94.1 µM -1.86210605320556 0.0179499406698711 no 3247 0.0312940714800716 1040 2169061
SGTC_2378 9074213 121.43 µM -1.86677234342528 0.0177229682804094 no 3248 0.0309666931088032 1051 657714
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.87420478921289 0.0173665052984616 no 3249 0.0304511021474036 1047 1241132 A phosphatase inhibitor.
SGTC_2254 7938975 95.19 µM -1.87972470961417 0.0171057464936385 no 3250 0.0300728030847958 1055 2969277
SGTC_150 3970-0969 77.2 µM -1.90124890571684 0.0161206757080517 no 3251 0.0286347090222403 1052 6615640
SGTC_725 1497-0963 19 µM -1.90793789919703 0.0158246233446031 no 3252 0.0281996215740578 1066 3549977
SGTC_747 3448-8087 38.7 µM -1.91057282322461 0.0157092892856417 no 3253 0.0280297498065915 1070 5168703
SGTC_1925 st057770 10.1 µM -1.91216753936608 0.0156398373530657 no 3254 0.0279273540989021 1051 5989122
SGTC_3264 9137442 49.47 µM -1.91587992433416 0.0154791780450331 no 3255 0.0276901906951582 1037 17015726
SGTC_302 1094-0063 18.9 µM -1.91628819677219 0.015461596183884 no 3256 0.0276642112120927 1057 5440289
SGTC_939 1165-0479 45.3 µM -1.92615692805035 0.0150417942127576 no 3257 0.0270423910633969 1050 1377347
SGTC_749 1000-0129 128 µM -1.93250168840432 0.014777101990456 no 3258 0.0266488069298036 1064 708470
SGTC_2247 cerulenin 830 nM -1.95081855698742 0.0140353169439956 no 3259 0.0255393167756148 1049 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_562 3772-2733 112 µM -1.9529254412755 0.013952087804548 no 3260 0.0254142152852948 1059 2876874 YIL048W NEO1
SGTC_1833 st055984 71 µM -1.95424108037472 0.0139003316521388 no 3261 0.0253363565790981 1070 676288
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.96021348598182 0.0136674584741115 no 3262 0.0249854214358214 1033 4330530
SGTC_273 hydroxyurea 18.1 mM -1.97921509865703 0.0129488120300448 no 3263 0.0238958968448936 1076 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_2932 9016711 44.54 µM -1.98026137388221 0.0129102087725908 no 3264 0.0238370833349487 1069 7117328
SGTC_1358 1509-0022 2.48 µM -1.9973597865244 0.0122933079975 no 3265 0.0228930564788755 1065 3258434
SGTC_1998 st075797 76.8 µM -2.00108242381806 0.0121624350905396 no 3266 0.022691754063883 1054 24208315
SGTC_1837 st055472 66.5 µM -2.00268987958716 0.0121062977974895 no 3267 0.0226052928733581 1064 676091
SGTC_1782 st039423 80.636 µM -2.00965895473432 0.0118655065412061 no 3268 0.0222336484684826 1076 2068169
SGTC_947 3447-0010 211 µM -2.01701219813211 0.0116159573164119 no 3269 0.0218471201834143 1067 748350
SGTC_835 0312-0010 67.2 µM -2.02332868337288 0.0114052439448024 no 3270 0.02151963576269 1066 1626196
SGTC_1945 st075991 56.6 µM -2.03621755965296 0.0109855609684773 no 3271 0.0208642568805407 1065 1084980
SGTC_531 3788-1495 174 µM -2.04666972297363 0.0106551509582144 no 3272 0.0203452619750953 1060 2896655
SGTC_1547 harmine 94.2 µM -2.05735616360423 0.0103263168273414 no 3273 0.0198259892791778 1044 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_521 r062-0005 13.8 µM -2.06608235030481 0.0100643995475457 no 3274 0.0194103522378981 1066 2832033
SGTC_2635 hydroquinidine 100 µM -2.06891837916196 0.00998053334425851 no 3275 0.0192768732931707 1067 442912 An experimental heart treatment.
SGTC_2621 lithochol-11-enic acid 100 µM -2.06914440605515 0.00997387566694239 no 3276 0.019266268882553 1067 6708711
SGTC_944 3370-0224 231 µM -2.07287100069284 0.00986466547290517 no 3277 0.0190921432532558 1061 4580514
SGTC_1213 1315-0166 115 µM -2.08226254439189 0.00959406036553493 no 3278 0.0186592475781438 1059 768401
SGTC_432 NS 1619 61.3 µM -2.08458057839649 0.00952827609073628 no 3279 0.018553694471468 1054 4552 A K+/calcium channel activator.
SGTC_32 0928-0142 34.1 µM -2.09515007750428 0.0092332944692139 no 3280 0.0180788267486903 1069 2244242
SGTC_2826 7992541 19.48 µM -2.10250980405222 0.00903264302361552 no 3281 0.0177543208710917 1072 2985066
SGTC_1568 digitonin 820 nM -2.1113425461457 0.0087968824004646 no 3282 0.0173714397772647 1052 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_949 1165-0505 146 µM -2.11610181512263 0.00867209961904097 no 3283 0.0171680745787268 1063 6244267
SGTC_246 cycloheximide 667 µM -2.11784268436731 0.00862684521598449 no 3284 0.017094196512039 1070 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2124 5246320 200 µM -2.12204763756159 0.00851838966483283 no 3285 0.0169168689350258 1064 579342
SGTC_1019 4262-0212 3.4 µM -2.12693455501664 0.00839384944615308 no 3286 0.0167127606299349 1068 4677213
SGTC_557 1315-0110 16.2 µM -2.13111358713342 0.00828862008676578 no 3287 0.0165398928131567 1075 6833801
SGTC_417 st075190 100 µM -2.1489657930098 0.00785203188392062 no 3288 0.0158185558217379 1077 222757
SGTC_2598 perillyl alcohol 100 µM -2.16228337606325 0.00753964420063037 no 3289 0.0152981701486014 1075 10819 An apoptosis inducer.
SGTC_735 3076-0345 636 µM -2.16710034086398 0.00742937936713225 no 3290 0.0151136019733933 1073 2888990
SGTC_1152 3909-8331 15.9 µM -2.17181490059589 0.00732283712438435 no 3291 0.0149348136544861 1064 16001939
SGTC_1607 st000305 50.6 µM -2.17802965784562 0.00718445170859618 no 3292 0.0147019144050931 1077 5457690
SGTC_1505 k297-0037 20.6 µM -2.22181766640572 0.00627312068081792 no 3293 0.0131478151612138 1084 4089396
SGTC_706 4262-0057 46.9 µM -2.23194359802963 0.00607754847738773 no 3294 0.0128093454511734 1081 883298
SGTC_2830 7992007 71.43 µM -2.27741049622729 0.00526443503225603 no 3295 0.0113808619471401 1068 1952075
SGTC_3179 9107801 49.47 µM -2.27869444951184 0.00524294989593931 no 3296 0.0113426174639007 1075 4818259
SGTC_606 k015-0008 38.6 µM -2.27950354034764 0.00522945100847912 no 3297 0.011318574878271 1085 1970475
SGTC_1504 k297-0033 30 µM -2.28339652152305 0.00516493180842911 no 3298 0.0112035109913664 1054 4388117
SGTC_1926 methyl fluorone black 53.6 µM -2.28930918225104 0.00506829474359516 no 3299 0.0110306972871856 1036 72721 Reacts with homocysteine.
SGTC_3116 9124943 49.47 µM -2.29154752216482 0.00503213331256258 no 3300 0.0109658833218185 1065 41905195 YPL160W CDC60
SGTC_741 4582-0002 126 µM -2.30674190810053 0.00479267624747621 no 3301 0.0105346062344353 1074 2912688
SGTC_2987 9018338 71.43 µM -2.31280684202594 0.00469996838757409 no 3302 0.0103666307225943 1075 5055682
SGTC_3341 9147222 25.867 µM -2.31347436639354 0.00468986304975228 no 3303 0.0103482862608707 1070 1939759
SGTC_2985 9022375 71.43 µM -2.31861802468822 0.00461264351657229 no 3304 0.0102078784499339 1070 4939335
SGTC_743 1275-0778 158 µM -2.33145673379861 0.00442482998369281 no 3305 0.00986464447625516 1060 2849257 YMR203W TOM40
SGTC_1162 k048-0130 20.1 µM -2.35351979617745 0.00411798271580439 no 3306 0.00929830881533539 1076 6797406
SGTC_1011 4112-3381 17.4 µM -2.35477292142595 0.0041011402647896 no 3307 0.00926701391569607 1074 2877139
SGTC_722 3534-0461 190 µM -2.36659612971955 0.00394524144079699 no 3308 0.00897625569366921 1074 658262
SGTC_3275 9138069 49.47 µM -2.37175253380961 0.00387892831059034 no 3309 0.00885197187580364 1082 17617007
SGTC_3292 9120825 59.784 µM -2.37545624599044 0.00383191546560313 no 3310 0.00876363513574135 1076 24824900
SGTC_428 3448-4153 16.5 µM -2.39080972407031 0.00364242730595077 no 3311 0.00840563143395926 1074 3834874
SGTC_2303 7774051 200 µM -2.39500218698462 0.00359216800799246 no 3312 0.00831013306963186 1082 2953184
SGTC_854 0422-0053 192 µM -2.40597832052475 0.00346352123313873 no 3313 0.00806461092142146 1087 3596728
SGTC_740 k014-0057 261 µM -2.43711917273189 0.00312075643861558 no 3314 0.00740239966279351 1081 4012779
SGTC_1470 k295-0292 231 µM -2.44951287824238 0.00299306062915123 no 3315 0.00715247971039035 1090 5045612
SGTC_1154 4088-0362 150 µM -2.45131332215272 0.00297490705802338 no 3316 0.00711679977516551 1082 6618304
SGTC_1506 4226-2149 212 µM -2.46339418590744 0.00285564268929521 no 3317 0.00688142563303388 1081 991114
SGTC_1533 dihydroergotamine mesylate 29.4 µM -2.46343372772343 0.00285525950986063 no 3318 0.00688066665614361 1084 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -2.47610759115327 0.00273480641011054 no 3319 0.00664117724656405 1079 115019
SGTC_962 1254-0300 21.5 µM -2.49744393662271 0.0025423488187403 no 3320 0.00625461217968108 1083 7340576
SGTC_2276 7947513 42.08 µM -2.51025789931778 0.00243273438021626 no 3321 0.00603215080324219 1081 2105100
SGTC_1571 st070080 73.4 µM -2.52634242977651 0.00230120154316102 no 3322 0.00576285391704513 1082 4315245
SGTC_2894 9048625 32.47 µM -2.61825569008365 0.00166557573178685 no 3323 0.00441902766426222 1080 4092861
SGTC_2325 6158266 200 µM -2.63619715341849 0.00156197462081137 no 3324 0.00419205014169783 1079 3623240
SGTC_2721 ifenprodil 61.44 µM -2.63864772727742 0.00154828944845571 no 3325 0.00416187127512886 1078 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1859 st055998 20 µM -2.72412923475395 0.00113417208523139 no 3326 0.00322356366497151 1086 676301
SGTC_1513 0337-0559 19 µM -2.74177131026699 0.00106250403159579 no 3327 0.00305544354172616 1085 775073
SGTC_3281 9140613 49.47 µM -2.75562010470697 0.00100918156125974 no 3328 0.00292904963575067 1073 16013766
SGTC_1943 st076331 65.2 µM -2.76901740930136 0.000959945183066731 yes 3329 0.0028112815387947 1093 24208415
SGTC_2832 7992762 51.95 µM -2.7700627944485 0.000956197622962129 yes 3330 0.0028022743209296 1072 2985177
SGTC_678 1218-2179 85.9 µM -2.77414379927704 0.000941696033511331 yes 3331 0.00276736037731843 1092 6820081 YOR116C RPO31
SGTC_2000 st075254 36.4 µM -2.78736508196874 0.000896091193422398 yes 3332 0.00265692881229776 1085 17234175
SGTC_2874 9043904 71.43 µM -2.80171742674758 0.000848889254787288 yes 3333 0.00254156876236821 1081 4463428
SGTC_1429 4049-0205 9.46 µM -2.81706258302235 0.000800960120846519 yes 3334 0.00242325404822411 1088 22774478
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM -2.84521682062485 0.000719444572379993 yes 3335 0.00221906009378804 1079 6857784
SGTC_2387 9077560 195.08 µM -2.86396619306313 0.000669477551635769 yes 3336 0.0020918633058906 1083 5303272
SGTC_2261 9010538 184.68 µM -2.86847957169107 0.000657937425857344 yes 3337 0.00206224916208021 1085 6457250
SGTC_3279 9140807 49.47 µM -2.88693586378859 0.000612631519558144 yes 3338 0.00194506759611863 1091 45595718
SGTC_2811 7967822 32.47 µM -2.92480059684533 0.000528565140283142 yes 3339 0.00172338503785269 1083 2232244
SGTC_2971 9092186 9.93 µM -2.93964778675684 0.000498618686092273 yes 3340 0.00164292764274083 1078 25236400
SGTC_797 k781-0471 270 µM -3.01737656365183 0.000365899292809285 yes 3341 0.00127486429453183 1092 23738129
SGTC_1341 1486-1360 280 µM -3.04441283973198 0.000328021507123275 yes 3342 0.00116567486840898 1092 3976547
SGTC_2589 lobaric acid 100 µM -3.07549048958435 0.000288999035462629 yes 3343 0.00105078315320763 1090 73157 A novel microtubule depolymerizer.
SGTC_2936 9038235 15.59 µM -3.08035523870139 0.000283297140502985 yes 3344 0.00103376916795271 1081 4749415
SGTC_1148 3909-7663 27.7 µM -3.10995204323286 0.000250804172706266 yes 3345 0.000935588607184868 1094 4084526
SGTC_695 3505-6186 243 µM -3.13067680115612 0.000230157592814528 yes 3346 0.000872019916687963 1090 1819379
SGTC_2105 5350118 200 µM -3.83890980295056 9.04992408108578e-06 yes 3347 6.17909076232287e-05 1094 2133313
SGTC_2797 7859098 81.82 µM -3.84013205581644 8.99496266790441e-06 yes 3348 6.14840732307737e-05 1085 972681
SGTC_2875 9039966 71.43 µM -4.07357968705872 2.72085742598877e-06 yes 3349 2.31480004599697e-05 1095 6463691
SGTC_2868 9035608 32.47 µM -4.25969797184423 1.00161229781289e-06 yes 3350 1.02351660622073e-05 1095 6462614
SGTC_1153 4055-0057 267 µM -4.45595507738936 3.34023885179391e-07 yes 3351 4.1760260746975e-06 1095 882706
SGTC_2965 9082772 38.63 µM -4.50375454210645 2.53874262630148e-07 yes 3352 3.33816575327376e-06 1039 16459634
SGTC_67 0335-0847 266 µM -4.6100325307791 1.3660271042954e-07 yes 3353 2.01302983556423e-06 1095 4552207 YOR254C SEC63
SGTC_2888 9058547 12.99 µM -4.76916628777724 5.26671465062143e-08 yes 3354 9.24949571551073e-07 1094 16476514
SGTC_175 3793-3120 23.7 µM -5.23945405951072 2.64063080720191e-09 yes 3355 8.05261658437845e-08 1094 5322297
SGTC_3062 9077494 49.47 µM -7.55129705972445 2.26800735940931e-17 yes 3356 2.15472322476256e-14 1072 16459633