SGTCid condition conc unit RIM1|YCR028C-A.score RIM1|YCR028C-A.strain.pval RIM1|YCR028C-A.strain.significant RIM1|YCR028C-A.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene SGTC_310 1273-0058 1.06 µM 8.90477380502501 3.00990823017225e-14 yes 1 2.6747507311639e-19 66 2734232 SGTC_236 1509-0011 5.31 µM 6.33487091699394 4.79302601121211e-08 yes 2 1.1877002965048e-10 285 3107280 SGTC_118 0083-0097 135.343 µM 6.19616466169547 9.08714179651851e-08 yes 3 2.89278004233171e-10 19 5207356 SGTC_967 1306-0166 352 µM 5.59515857813047 1.24553004574529e-06 yes 4 1.10210103939795e-08 5 4437607 SGTC_1016 4226-1401 38 µM 5.41698439167309 2.5798627668926e-06 yes 5 3.03063148419029e-08 5 2901613 SGTC_116 0155-0182 31.788 µM 5.39932460794603 2.76964501708314e-06 yes 6 3.34461222531683e-08 34 771486 SGTC_275 trichlorophene 5.69 µM 5.3303423075017 3.64711483075938e-06 yes 7 4.90139100866668e-08 150 62616 SGTC_2183 6420625 130.508 µM 5.22703300255107 5.47390457654859e-06 yes 8 8.61258818918253e-08 26 2897619 SGTC_119 0121-0043 24.815 µM 5.03336768241279 1.14898266514546e-05 yes 9 2.40968750716343e-07 52 1092378 SGTC_1150 3909-7983 10.9 µM 4.8858836515608 1.9863750464938e-05 yes 10 5.14829964161042e-07 9 23965914 SGTC_3056 9094900 49.47 µM 4.87948696963355 2.03341837626093e-05 yes 11 5.31810749848861e-07 7 25236784 SGTC_2844 9010103 25.97 µM 4.86266334518511 2.16224355099075e-05 yes 12 5.79083666925917e-07 12 2480525 SGTC_2433 5607874 27.82 µM 4.63464417424322 4.87768665418156e-05 yes 13 1.78775983367456e-06 10 2252428 SGTC_195 4234-0266 16.654 µM 4.53677080823822 6.84148009750516e-05 yes 14 2.85610628811214e-06 19 2303354 SGTC_2712 st079126 47.7 µM 4.46616740407198 8.69743895509629e-05 yes 15 3.98166532837615e-06 8 3152970 SGTC_2704 st078022 71.1 µM 4.43857166708901 9.54410908472478e-05 yes 16 4.52789157957662e-06 10 54697681 SGTC_28 pentachloropyridine N-oxide 1.606 µM 4.22081132501006 0.000195090498560675 yes 17 1.2171230864742e-05 60 140250 A respiratory chain inhibitor. SGTC_1939 st074455 53.6 µM 4.19382615659735 0.000212688619793287 yes 18 1.37144110321218e-05 24 1644229 SGTC_1178 0988-0033 191 µM 4.19023287220388 0.000215140735273016 yes 19 1.39334154435562e-05 22 5392207 SGTC_173 1273-0061 2.693 µM 4.18844439812241 0.000216371033411498 yes 20 1.40436552353244e-05 178 2847414 YPL266W DIM1 SGTC_124 0136-0217 7.121 µM 4.14633600600529 0.000247306294006866 yes 21 1.68918975023515e-05 54 3976905 SGTC_1188 1403-0014 4.57 µM 4.02428620210087 0.000361842450057846 yes 22 2.8574192042569e-05 47 9614867 SGTC_1576 erythromycin ethylsuccinate 23.2 µM 3.9855222268419 0.000407478266545891 yes 23 3.36659368653881e-05 19 3256 An antibiotic and ribosome inhibitor. SGTC_63 0099-0242 26.702 µM 3.80711878926117 0.000694814096776142 yes 24 7.02976112928158e-05 95 3898502 YLR359W ADE13 SGTC_204 PMA1.184 62.41 µM 3.74497822347557 0.000832573302652412 yes 25 9.02047117271958e-05 38 2252213 YGL008C PMA1 SGTC_691 1548-0686 185 µM 3.71335305118411 0.000911949423031455 yes 26 0.000102265622870882 45 46495133 SGTC_2232 chlorophetanol 41.5365 µM 3.65762213612854 0.00106895346155311 no 27 0.000127282982394441 143 15907 An antifungal of unknown mechanism. YFR051C RET2 SGTC_2459 5811157 9.22 µM 3.64419664636761 0.0011103081798507 no 28 0.000134114144227258 22 2870684 YBR192W RIM2 SGTC_26 0302-0163 425.158 µM 3.56264782370224 0.00139461862822156 no 29 0.000183566526758445 16 3100915 SGTC_10 0279-0212 42.575 µM 3.55296521311521 0.00143246491586128 no 30 0.000190457416611273 153 39851 YBR002C RER2 SGTC_2172 5754775 163.918 µM 3.55257217842935 0.00143402078411174 no 31 0.000190742172415271 25 2263357 SGTC_1965 Pectolinarigenin 58.4 µM 3.54008907598624 0.00148424625309237 no 32 0.000199996001069965 19 5320438 An anti-inflammatory. SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM 3.51836021011061 0.00157551514217889 no 33 0.000217111259977471 38 5355888 SGTC_1742 st038235 28.8875 µM 3.5163994815509 0.00158399753842827 no 34 0.000218721131209646 137 564103 YBR002C RER2 SGTC_113 0099-0221 2.5 µM 3.51531622369964 0.001588701700336 no 35 0.000219615320413146 42 89219 SGTC_2832 7992762 51.95 µM 3.43124427737654 0.00199509102732912 no 36 0.000300409651706646 47 2985177 SGTC_1198 1612-1005 86.7 µM 3.41505263785419 0.00208343795566898 no 37 0.000318848433818332 26 6998509 SGTC_2543 pimpinellin 60.67 µM 3.39695936084052 0.002186348545912 no 38 0.00034069542782024 34 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo. SGTC_511 blebbistatin 171 µM 3.33152491989581 0.00259812783745477 no 39 0.000431857832991534 34 3476986 A myosin inhibitor. SGTC_3073 9114972 49.47 µM 3.30119968799221 0.00281174144521583 no 40 0.00048136168290887 29 41905075 SGTC_545 4218-0007 221 µM 3.25239624363046 0.00318894409445177 no 41 0.00057218183696748 53 2840508 SGTC_3179 9107801 49.47 µM 3.24760968756805 0.00322828837950648 no 42 0.000581893984298127 30 4818259 SGTC_601 0986-0029 62.9 µM 3.24302693279463 0.00326636611115971 no 43 0.000591335154325064 72 24747981 SGTC_120 rhodamine 6G 52.259 µM 3.23783457781426 0.00330999670428388 no 44 0.000602203114485712 66 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase SGTC_2688 kanamycin b 96.69 µM 3.23607381799057 0.00332491065970361 no 45 0.000605930202234649 485 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis. SGTC_1461 k072-0203 53.8 µM 3.23441137618224 0.00333904726491345 no 46 0.000609468720234405 35 5418714 SGTC_519 k048-0011 62.8 µM 3.19761238598172 0.00366612377320753 no 47 0.000692852015931596 52 6836379 SGTC_2283 7944793 200 µM 3.18970726746963 0.00374002958543927 no 48 0.000712084863290015 80 2970533 SGTC_2855 9016525 58.44 µM 3.18354760143453 0.00379854015795471 no 49 0.000727410952849388 52 43811474 SGTC_1064 honokiol 6.76 µM 3.16794943624048 0.00395039356906089 no 50 0.000767591091539137 51 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis. SGTC_2122 5258151 111.688 µM 3.15644355795888 0.00406586830882843 no 51 0.000798528964734292 49 2173356 SGTC_1015 4130-4525 82 µM 3.14271745769818 0.00420757127166218 no 52 0.000836936636622628 56 1363237 SGTC_2921 7974240 10.71 µM 3.13458307300532 0.0042936169587255 no 53 0.000860492588093055 95 2979074 YDR527W RBA50 SGTC_1183 1254-0324 198 µM 3.13179055810792 0.00432351694277017 no 54 0.000868718855581494 55 5799357 SGTC_648 0375-0473 33.3 µM 3.10951658331133 0.00456874900641748 no 55 0.000936968823930859 49 1713139 SGTC_187 1488-2104 32.728 µM 3.10460989658403 0.00462441140546836 no 56 0.000952650663874705 70 2852859 SGTC_386 1509-0011 3.07 µM 3.09890803113554 0.00468985409030268 no 57 0.000971176521801487 190 3107280 SGTC_948 3448-0295 75.3 µM 3.0720418950375 0.00500945650817504 no 58 0.00106299941990977 79 678569 SGTC_2526 patulin 37.61 µM 3.06138033791815 0.00514157098726096 no 59 0.0011015951825769 160 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.  SGTC_2967 9089538 49.85 µM 3.04176954009125 0.00539270123843569 no 60 0.00117595944295898 79 728216 SGTC_3211 9128781 49.47 µM 3.03394556387585 0.00549589776544423 no 61 0.00120688990030906 120 17194361 SGTC_480 am 92016 50 µM 3.01731249376497 0.00572113353274774 no 62 0.00127513380499516 51 2129 K+ channel blocker. SGTC_283 0987-0079 11.7 µM 3.01636507189832 0.00573420618703027 no 63 0.00127912522923642 76 411556 SGTC_471 1-acyl-paf 4 µM 3.01586541619684 0.00574111117596201 no 64 0.00128123484374306 64 16759367 SGTC_945 3381-0768 11.3 µM 2.98183368982339 0.00622913261766843 no 65 0.0014326380183948 77 1126236 YIL048W NEO1 SGTC_19 0279-0214 38.434 µM 2.94948701591543 0.00672668486483536 no 66 0.00159150973731957 118 3566274 YBR002C RER2 SGTC_1763 st044482 94.5 µM 2.94804250447091 0.00674970123529751 no 67 0.00159896545918367 58 88505 SGTC_1069 diphenylcyclopropenone 8.49 µM 2.94392843510345 0.00681563523015 no 68 0.00162037463527486 79 65057 A dermal irritant. YDR527W RBA50 SGTC_1961 st076550 68.7 µM 2.94388348288724 0.00681635878659973 no 69 0.0016206099974885 55 1579337 SGTC_440 fluspirilene 35.1 µM 2.93866929424032 0.00690074880385727 no 70 0.00164812291196719 66 3396 An atypical antipsychotic. SGTC_123 0083-0120 66.675 µM 2.92812984419007 0.00707414830597906 no 71 0.00170503801807218 96 16001701 SGTC_2610 ononetin 44.17 µM 2.92741731314592 0.00708600872907688 no 72 0.0017089496554182 105 259632 SGTC_2842 9000675 19.48 µM 2.92562002195666 0.00711600348922234 no 73 0.00171885270397439 74 2989072 SGTC_2790 5423970 71.43 µM 2.91947961989923 0.00721932666941714 no 74 0.00175308159612158 133 1376240 YKL165C | YIL048W MCD4 | NEO1 SGTC_2710 st078562 53.7235 µM 2.9145286005337 0.00730359752682559 no 75 0.00178113083264954 50 17250908 SGTC_2964 9083345 53.42 µM 2.90894293817698 0.00739971061309854 no 76 0.00181326522576454 68 17741579 SGTC_2156 5649887 115 µM 2.87126241918392 0.00807769888850392 no 77 0.00204417986874119 67 54680440 YKL052C | YBR257W ASK1 | POP4 SGTC_91 0417-1751 58.384 µM 2.85831477333883 0.00832295984078547 no 78 0.00212948837909755 123 6795624 SGTC_2233 sulbentine 40.3845 µM 2.85710920640051 0.00834612568998618 no 79 0.00213759359842654 135 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58 SGTC_357 1325-0123 420 µM 2.85532902950023 0.00838043660891074 no 80 0.00214961317386966 42 1098503 SGTC_1268 0828-0275 2.46 µM 2.85412712967085 0.00840367185313163 no 81 0.00215776290118084 76 745337 SGTC_1631 benzylvanillin 81.9 µM 2.84403837615038 0.00860094854251132 no 82 0.00222728411589034 88 75506 SGTC_800 3448-7362 155 µM 2.83323812601676 0.00881662899884702 no 83 0.00230395229766024 301 15991913 SGTC_2460 5552655 174.22 µM 2.82556606850475 0.00897270559779442 no 84 0.00235985767922119 93 5401989 SGTC_946 3434-1334 87.4 µM 2.8138715309209 0.00921527021101972 no 85 0.0024474392992365 82 4047976 SGTC_580 1123-0028 41 µM 2.80944183046716 0.00930863751021195 no 86 0.0024813743257225 110 1677248 YPR107C YTH1 SGTC_969 1313-0238 134 µM 2.7773395009349 0.0100103543415713 no 87 0.00274029499733914 93 5212874 SGTC_2581 avocatin a 64 µM 2.7551332162173 0.0105223739394458 no 88 0.00293341214053526 121 6710728 A skin care supplement. SGTC_1922 5578187 25 µM 2.74836231956908 0.0106829666078364 no 89 0.00299468916288075 107 1350412 SGTC_1490 4089-0339 670 nM 2.7366338275053 0.0109661980096263 no 90 0.0031035670966857 44 742542 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 2.73144752022939 0.0110935111849191 no 91 0.00315283913449554 117 5711223 A potent inhibitor of glutathione S-transferases. SGTC_982 1491-0518 27.5 µM 2.73098081293727 0.0111050306812244 no 92 0.00315730739145778 69 3091256 SGTC_141 0443-0274 32.331 µM 2.72764270912185 0.0111877270867567 no 93 0.00318943293046253 146 1627241 SGTC_579 4491-1009 110 µM 2.72555953837873 0.0112396053282747 no 94 0.00320962989239935 94 1271041 SGTC_1460 k062-0059 9.15 µM 2.70370683128494 0.0117965393831237 no 95 0.00342853790670113 78 1373085 SGTC_614 0462-0418 107 µM 2.70171761046164 0.0118484056644231 no 96 0.00344911614505445 109 5188303 SGTC_2089 5281248 129.67 µM 2.69615432586632 0.0119945126255153 no 97 0.00350725800341247 90 2737878 SGTC_3255 9139072 49.47 µM 2.69472554709592 0.0120322874539832 no 98 0.00352233151683743 85 17646060 SGTC_134 0269-0018 6.916 µM 2.68791709721937 0.0122137132254692 no 99 0.00359496224203054 230 4378915 SGTC_3165 9101544 49.47 µM 2.66505154229564 0.0128404728601296 no 100 0.00384882618845256 65 5002184 SGTC_432 NS 1619 61.3 µM 2.66083862612018 0.0129589375659846 no 101 0.00389731524216609 107 4552 A K+/calcium channel activator. SGTC_2381 9035592 200 µM 2.64808431836848 0.0133233598088196 no 102 0.00404746661683465 90 4749657 SGTC_2501 sodium tetradecyl sulfate 13.37 µM 2.63986055271552 0.0135629983106767 no 103 0.00414700732816409 132 23665772 A membrane-active detergent. SGTC_1431 4049-0260 9.09 µM 2.63970989031447 0.0135674230538088 no 104 0.00414885120447011 67 3854841 SGTC_1453 4237-0541 195 µM 2.63051276888489 0.0138398994473377 no 105 0.00426280834091975 102 739892 SGTC_1663 st014140 55.4 µM 2.62244811758299 0.0140826954711642 no 106 0.0043650279414423 105 4207120 SGTC_1371 2421-0008 32.7 µM 2.60995192911306 0.0144661570298876 no 107 0.00452774732866148 143 2827552 SGTC_3131 9127911 49.47 µM 2.59658627134311 0.0148862143743884 no 108 0.00470776289117 107 45595681 SGTC_307 1501-1223 22.3 µM 2.57506160892877 0.0155847361663727 no 109 0.00501111164858495 80 2830329 SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 2.57304886799378 0.0156514692765715 no 110 0.00504034864630495 64 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA. SGTC_904 1141-0088 396 µM 2.56719002675678 0.0158471183736296 no 111 0.00512632047068293 95 1378119 SGTC_686 1319-0111 510 µM 2.56075579257134 0.0160643947290458 no 112 0.00522223722245195 104 4562600 SGTC_397 arbidol 50 µM 2.55439563186159 0.0162816738993346 no 113 0.00531861570526228 104 131410 A RNA synthesis inhibitor. SGTC_624 k048-0052 28 µM 2.55134271029283 0.0163868604076028 no 114 0.00536543743517578 103 6835531 SGTC_276 colchicine 750 µM 2.5466970956104 0.0165480383763974 no 115 0.0054373890698087 112 2833 A microtubule depolymerizer. SGTC_932 2857-0803 154 µM 2.49974107681241 0.0182547435556904 no 116 0.0062142052783775 106 674898 SGTC_2427 5545055 42.75 µM 2.49587389991041 0.0184017596987635 no 117 0.0062823629447238 120 5372858 SGTC_508 roscovitine 141 µM 2.4692680523434 0.0194408052020947 no 118 0.00676948792340964 66 160355 A CDKinase inhibitor. SGTC_679 0422-0091 41.4 µM 2.46744297218428 0.0195138719579717 no 119 0.00680409478222268 149 627384 YHR062C RPP1 SGTC_1883 5-benzylidenerhodanine 20 µM 2.46351193514344 0.0196720428638346 no 120 0.00687916573832419 205 1273210 SGTC_3178 9107506 49.47 µM 2.45163648363501 0.0201564950310153 no 121 0.00711041223634998 109 8897194 SGTC_127 0180-0333 59.125 µM 2.45139169890445 0.0201665863621062 no 122 0.00711525013267664 189 771601 SGTC_211 3455-0679 143.504 µM 2.42148025363047 0.0214323633939555 no 123 0.00772872040432786 133 748649 SGTC_1477 0139-0234 16 µM 2.40600500720872 0.0221131849252325 no 124 0.00806402182874547 102 620880 SGTC_3070 9117005 49.47 µM 2.39605940497257 0.0225602991348532 no 125 0.00828620208643305 72 8779016 SGTC_1597 7-benzyloxygramine 47.5 µM 2.38683177175402 0.0229819293350513 no 126 0.00849713287851041 323 260807 SGTC_2589 lobaric acid 100 µM 2.38427938571992 0.0230997183699571 no 127 0.00855630253970999 153 73157 A novel microtubule depolymerizer. SGTC_2629 bisabolol 100 µM 2.37851130673851 0.0233677806194984 no 128 0.00869135190987825 144 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer. SGTC_832 4083-0019 164 µM 2.37703916466553 0.0234366138613942 no 129 0.00872611750190778 314 1990758 SGTC_186 3455-3465 67.277 µM 2.37654379008421 0.0234598145181295 no 130 0.00873784348148902 44 755278 SGTC_2016 5121758 140 µM 2.3698462794223 0.0237753908906887 no 131 0.00889774114076292 192 2795203 SGTC_1479 0549-0158 134 µM 2.3682342378931 0.0238518784275969 no 132 0.00893660803257173 164 5440202 SGTC_1963 st076565 50.3 µM 2.3627891452139 0.0241117660510104 no 133 0.00906899304248161 108 4914280 SGTC_1906 st060206 94.7 µM 2.36091906816997 0.0242015695765751 no 134 0.00911485425112944 147 5133468 SGTC_2853 9015042 58.44 µM 2.35653854075885 0.0244130284058301 no 135 0.0092230766911372 133 6457456 SGTC_1766 st045414 44.774 µM 2.35508905897413 0.0244833390945049 no 136 0.00925913343503688 171 253960 SGTC_717 1532-0246 73.2 µM 2.34368494520846 0.0250424746299513 no 137 0.00954714647047015 159 9561992 SGTC_2203 7227154 166.4 µM 2.34201328188838 0.0251253277702346 no 138 0.00959001617613474 105 896304 SGTC_3043 9092303 49.47 µM 2.32841509664135 0.0258078714565027 no 139 0.0099450363965615 138 25236084 SGTC_1944 st076371 56.9 µM 2.31429063229708 0.026533191348453 no 140 0.0103258926510713 168 24208455 SGTC_1534 6-azauridine 81.6 µM 2.30540217170789 0.0269983048787189 no 141 0.0105720299951078 172 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1 SGTC_3184 9108758 49.47 µM 2.30533822403835 0.0270016756173558 no 142 0.0105738191809479 88 902885 SGTC_1148 3909-7663 27.7 µM 2.30479998527314 0.0270300605845638 no 143 0.0105888889696803 135 4084526 SGTC_1186 1319-0216 26 µM 2.30101098439341 0.0272305857071591 no 144 0.0106955051033665 155 4565136 SGTC_3225 9130819 49.47 µM 2.29640631139643 0.0274759475824446 no 145 0.0108263302225623 143 4547121 SGTC_2422 chlorphenesin carbamate 384.24 µM 2.28782317029628 0.0279382244576699 no 146 0.0110739104677888 206 2724 A muscle relaxant with antifungal properties. SGTC_2908 7930301 100 µM 2.26174383728979 0.0293827306568004 no 147 0.0118566173002298 192 2223178 SGTC_820 1582-0060 59.9 µM 2.26059356370423 0.0294478451391624 no 148 0.0118922183398781 178 3848840 SGTC_908 3448-7491 47.7 µM 2.25974234493588 0.0294961078716062 no 149 0.0119186232812967 320 1203031 SGTC_2171 5739187 198.077 µM 2.25176346937709 0.0299516974812301 no 150 0.0121686116760286 111 2262761 SGTC_583 1488-1091 88.9 µM 2.24098872116883 0.0305761772033443 no 151 0.0125134028031839 184 4303273 SGTC_1342 1486-1464 234 µM 2.23911513684858 0.0306858588662077 no 152 0.0125742128096919 148 3253938 SGTC_3290 9121031 71.43 µM 2.23404415403361 0.0309843548596866 no 153 0.0127400839836801 124 17014854 SGTC_738 1315-0003 72.4 µM 2.22703317422629 0.0314009997223333 no 154 0.0129725283671325 167 6251474 SGTC_544 k015-0020 52.4 µM 2.22137287117388 0.0317407473368093 no 155 0.0131628584618731 158 3008304 SGTC_2011 4012611 177 µM 2.21251432934623 0.0322785542875647 no 156 0.0134655736089361 191 2049887 SGTC_2085 5307070 144.047 µM 2.21219604683076 0.0322980165005833 no 157 0.0134765609428382 153 2840351 SGTC_3140 9094243 49.47 µM 2.21190107556606 0.0323160619317582 no 158 0.0134867504655389 188 19291112 SGTC_697 0508-1955 564 µM 2.20967684233207 0.0324524017281317 no 159 0.0135637990260393 196 6243113 SGTC_877 0771-0151 33.1 µM 2.20512190255759 0.0327330890213104 no 160 0.0137227707592077 157 6166523 SGTC_192 3455-0609 60.9 µM 2.1984603146422 0.0331471952770754 no 161 0.0139581598144673 149 3769639 SGTC_2824 7998404 51.95 µM 2.1961973144541 0.0332888491761167 no 162 0.014038911759815 161 837851 SGTC_2510 benzyl isothiocyanate 8.31 µM 2.19613188660786 0.0332929520767332 no 163 0.0140412524362034 149 2346 DNA damaging agent; causes G2/M arrest. SGTC_1738 st035555 74 µM 2.19383506063513 0.033437247374636 no 164 0.0141236346464259 205 5331140 SGTC_2082 5219693 150 µM 2.19264966975777 0.0335119193248404 no 165 0.01416631477791 194 2834649 SGTC_609 0986-0026 86.3 µM 2.19123584680187 0.033601160465814 no 166 0.0142173648974639 205 2848610 SGTC_2716 st080858 38.6235 µM 2.19063058682887 0.0336394244928882 no 167 0.0142392679369762 144 5296050 SGTC_2614 arthonioic acid 13.39 µM 2.18575799251768 0.0339487739724611 no 168 0.0144166577911816 155 6710684 SGTC_2729 fluphenazine 10.66 µM 2.18179049586059 0.0342023857639218 no 169 0.0145624991684087 171 3372 An atypical antipsychotic. SGTC_147 4466-0538 29.23 µM 2.16195597607772 0.0354937124618621 no 170 0.0153107848556219 204 6742687 YHR072W ERG7 SGTC_1052 3253-3998 198 µM 2.15337060764839 0.0360649267888737 no 171 0.0156447818322243 212 5450317 SGTC_2154 5570129 200 µM 2.14674864135927 0.0365106335536359 no 172 0.0159066490358319 188 673366 SGTC_673 1082-0474 110 µM 2.14094817487244 0.0369047410432066 no 173 0.0161391087951115 269 3098046 SGTC_1972 st070201 17.4 µM 2.13626393931786 0.0372255398050847 no 174 0.016328953199601 170 2829099 SGTC_87 0100-0052 35.5 µM 2.13353955806375 0.0374131639882593 no 175 0.0164402450960453 411 200187 YGR083C | YDR527W GCD2 | RBA50 SGTC_563 tetrahydrosecaminediol 614 µM 2.13027130273915 0.0376392623058991 no 176 0.0165746106693259 193 334274 A psychoactive constituent of the cannabis plant. SGTC_2086 5274770 176.623 µM 2.12333666216788 0.0381226966951701 no 177 0.0168628252976292 188 689278 SGTC_2603 homopterocarpin 100 µM 2.12309347085427 0.038139741772866 no 178 0.0168730100200798 235 101795 A weak amylase inhibitor. SGTC_788 1182-0090 188 µM 2.12153863216866 0.0382488660894825 no 179 0.0169382502426038 291 5715185 SGTC_3037 9091026 49.47 µM 2.11337744823703 0.0388258305663762 no 180 0.0172842373060961 359 25236398 YIL048W NEO1 SGTC_2095 5432005 200 µM 2.11215080805643 0.0389131589887305 no 181 0.0173367581282655 154 783734 SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 2.09580898060106 0.0400919178761606 no 182 0.0180495696926235 172 5357218 A potent inhibitor of glutathione S-transferases. SGTC_1541 2',3',6-trimethoxyflavone 64 µM 2.08140765384333 0.0411546034224614 no 183 0.0186983043519318 201 688801 SGTC_391 gliotoxin 8.33 µM 2.07970692568347 0.0412815956253193 no 184 0.0187762112358513 242 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion SGTC_1319 1306-0155 43.7 µM 2.07823567029063 0.0413917093394099 no 185 0.0188438291034386 241 3122360 SGTC_2344 7990960 76.95 µM 2.07654560918971 0.0415184928573964 no 186 0.0189217587060078 198 140813 SGTC_1449 4112-4002 201 µM 2.07593342341142 0.0415644948296733 no 187 0.0189500544682607 164 2059539 SGTC_1147 3809-1045 12.3 µM 2.07414898962139 0.0416988196348934 no 188 0.0190327379909699 216 325925 SGTC_707 0865-0008 204 µM 2.07188514099502 0.0418697385694695 no 189 0.0191380770067078 157 723043 SGTC_2808 7946468 45.46 µM 2.05538407366568 0.0431327591706419 no 190 0.0199209612780546 245 2970879 SGTC_1107 amlodipine 47 µM 2.04991942827921 0.043557753351911 no 191 0.0201861469872827 233 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.  SGTC_2361 9034121 116 µM 2.04798265384562 0.0437091881304066 no 192 0.0202808495430175 182 6496917 SGTC_1127 asiatic acid 681.4 nM 2.04709860069195 0.0437784525728767 no 193 0.0203242021764709 222 470603 A kinase inhibitor which arrests cells at G2/M. SGTC_1194 1488-0194 225 µM 2.04698156493798 0.043787628809329 no 194 0.0203299473171364 228 1391452 SGTC_2826 7992541 19.48 µM 2.04559652607399 0.0438963412327281 no 195 0.0203980417711888 211 2985066 SGTC_2423 st077119 87.2 µM 2.04519429122155 0.0439279536152809 no 196 0.0204178535455859 201 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae). SGTC_1481 3346-2004 36 µM 2.03729401628554 0.0445525810703984 no 197 0.02081029355931 187 2770522 SGTC_3169 9102970 49.47 µM 2.03478265526758 0.0447526314168198 no 198 0.0209363735263146 133 17027839 SGTC_1172 0370-0043 85 µM 2.02819064594423 0.0452811812491108 no 199 0.0212703971127556 183 376585 SGTC_696 1560-0013 611 µM 2.02627355682067 0.0454358332378317 no 200 0.021368379738995 208 1650269 SGTC_177 1327-0068 8.361 µM 2.0193784192551 0.0459955799762179 no 201 0.0217239514131987 257 15389900 YOR207C | YLR033W RET1 | RSC58 SGTC_782 0083-0095 30.5 µM 2.01534103658167 0.0463258975776431 no 202 0.0219344639742301 261 3591729 An indicator and reagent. SGTC_933 2914-0560 114 µM 2.00440195006457 0.0472304543786934 no 203 0.0225135103005341 240 463887 SGTC_2390 9097792 176.6 µM 1.99933279424103 0.0476543977507937 no 204 0.0227861790747971 190 4497149 SGTC_596 1155-0152 116 µM 1.99932081648552 0.0476554030710314 no 205 0.0227868266365309 284 280313 SGTC_2112 5488546 200 µM 1.99083801437245 0.0483716604988008 no 206 0.0232493493091705 237 600757 SGTC_417 st075190 100 µM 1.9894801186291 0.0484871117399491 no 207 0.0233241170614113 225 222757 SGTC_2943 9068529 45.32 µM 1.98762007783739 0.0486456139653107 no 208 0.0234268620257781 235 3270634 SGTC_2773 thioridazine 9.09 µM 1.98608539483504 0.0487767026597411 no 209 0.0235119213532845 193 5452 An antipsychotic. SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM 1.98359010705336 0.0489904463172523 no 210 0.0236507764785795 242 6710655 SGTC_3252 9135871 49.47 µM 1.9813077640076 0.0491866039719375 no 211 0.0237783851157056 199 17682838 SGTC_675 1309-0189 238 µM 1.98062811374955 0.0492451380633604 no 212 0.0238164968749122 204 4246530 SGTC_861 0443-0273 110 µM 1.97752610375174 0.049513001717921 no 213 0.0239910964311458 209 6149169 SGTC_2882 9058044 58.44 µM 1.97425520157735 0.0497967077690701 no 214 0.0241763660097228 194 18076804 SGTC_1991 st073000 8.92 µM 1.96550454322476 0.0505620859800727 no 215 0.0246779351766334 315 4301969 YIL048W NEO1 SGTC_1745 st081495 74 µM 1.96183028773338 0.0508862361873642 no 216 0.024891123093962 330 13842402 YBL026W LSM2 SGTC_1679 SEC14.276 6.7 µM 1.95193891612747 0.0517670988621392 no 217 0.0254727286211689 285 1005053 YMR079W SEC14 SGTC_126 0417-1624 672.48 µM 1.94997953151342 0.0519430190661129 no 218 0.025589279359424 315 41912 YDL195W SEC31 SGTC_1013 4112-3890 241 µM 1.94985953822838 0.051953807887948 no 219 0.0255964314460891 248 705171 SGTC_2400 5203494 178.7 µM 1.9486808931518 0.0520598767479595 no 220 0.0256667724753439 223 6777674 SGTC_5 0352-0601 109.883 µM 1.94714502359602 0.0521983510816063 no 221 0.0257586752554403 173 762456 SGTC_2917 7979103 53.79 µM 1.94601438469936 0.0523004765460962 no 222 0.0258265058601677 284 2980565 SGTC_2900 5328528 85.29 µM 1.94579254425999 0.0523205329899619 no 223 0.0258398322958512 277 795359 SGTC_1623 st003709 20.3 µM 1.94517603512765 0.0523763032338034 no 224 0.0258768975537422 337 16192618 SGTC_1289 0976-0073 69.1 µM 1.94388339011075 0.0524933908617297 no 225 0.0259547573369388 224 3391136 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.94274073502183 0.0525970653422333 no 226 0.0260237458898059 197 6857784 SGTC_314 1671-0008 2.74 µM 1.93787824686831 0.0530400630614463 no 227 0.026319039243596 302 3913060 SGTC_2786 7743617 45.45 µM 1.93255410679947 0.0535285076543343 no 228 0.026645575298647 212 583674 SGTC_629 3448-6466 76.7 µM 1.92812297005739 0.0539377382120831 no 229 0.0269199162529919 257 573744 SGTC_582 0987-0078 156 µM 1.92577012015871 0.0541560364972146 no 230 0.0270665419695518 371 1625765 SGTC_2860 9025725 38.96 µM 1.92249602709172 0.0544609708130015 no 231 0.0272716865118121 204 40546248 SGTC_909 3448-9333 149 µM 1.92111758156628 0.0545897585841187 no 232 0.0273584427820713 217 3344074 SGTC_467 ro 31-8220 72.8 µM 1.9200504101415 0.0546896294046928 no 233 0.0274257661267072 311 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7 SGTC_961 1252-1571 372 µM 1.91856567830975 0.0548288176851071 no 234 0.0275196613466633 259 6813498 SGTC_3129 9127257 49.47 µM 1.9160824826994 0.0550622339588619 no 235 0.0276772988164744 231 837894 SGTC_446 go6976 132 µM 1.91460532668997 0.0552014561650174 no 236 0.0277714276558649 200 3501 A protein kinase C inhibitor. SGTC_2487 5918373 44.05 µM 1.90821762487861 0.055806701715759 no 237 0.0281815472835116 252 2876279 SGTC_1607 st000305 50.6 µM 1.90191532446116 0.0564089748987715 no 238 0.0285911127144449 234 5457690 SGTC_2332 7982454 138.89 µM 1.90148697310018 0.0564500950908967 no 239 0.0286191285989429 309 2981748 SGTC_148 3253-0744 288.01 µM 1.90078824914502 0.0565172207732195 no 240 0.0286648769231667 238 6893655 SGTC_1678 st019265 80.2 µM 1.90058773669899 0.0565364954055481 no 241 0.0286780165204934 282 5367020 SGTC_657 3534-0529 86.7 µM 1.90048754848545 0.0565461281246403 no 242 0.028684583738834 243 1049549 SGTC_2731 amoxapine 43.43 µM 1.89196346918361 0.0573704324898587 no 243 0.0292479241207759 114 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine. SGTC_2337 9009472 200 µM 1.88674431598493 0.0578797885737252 no 244 0.0295973619856055 306 5742383 SGTC_620 0109-0052 432 µM 1.88379199129375 0.0581694869230715 no 245 0.0297965586417881 248 493037 SGTC_2653 dihydrofissinolide 100 µM 1.87743048531571 0.0587975842669497 no 246 0.0302295582601593 184 6857746 SGTC_414 piperonyl butoxide 100 µM 1.87302259864226 0.0592359056862139 no 247 0.0305326322156864 211 5794 A potent inhibitor of cytochrome P450. SGTC_926 2268-1401 59.4 µM 1.8719852890181 0.0593394275611361 no 248 0.0306043193869942 263 2931578 SGTC_735 3076-0345 636 µM 1.86313961404674 0.0602279837104638 no 249 0.0312213130400774 314 2888990 SGTC_1022 4477-0945 21.3 µM 1.85579873997703 0.06097326088773 no 250 0.0317411251257003 283 4648966 SGTC_1024 4507-0395 26 µM 1.85361108143576 0.0611967502419629 no 251 0.0318974105364997 271 4201836 SGTC_210 3551-0445 56.827 µM 1.85008708259028 0.0615581044815317 no 252 0.0321504997051772 289 2865180 YOR207C RET1 SGTC_3027 9089541 49.47 µM 1.84963012528206 0.0616050831170231 no 253 0.0321834388917306 274 9943819 SGTC_2091 4-phenylthiadiazole 200 µM 1.84903615278064 0.0616661897817148 no 254 0.0322262962776567 290 270010 SGTC_484 loperamide 105 µM 1.84433957951393 0.062151031430756 no 255 0.0325668333766466 137 3955 An opioid-receptor agonist. SGTC_2405 ticlatone 3.52 µM 1.83693450932062 0.0629215139711658 no 256 0.033109782035162 325 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W SGTC_1834 st055981 52.8 µM 1.81666958309091 0.0650681009812592 no 257 0.0346338609228553 294 471719 YDL150W RPC53 SGTC_2063 5246145 200 µM 1.81204472904143 0.0655658699189826 no 258 0.0349896427354765 306 711240 SGTC_713 1488-1073 324 µM 1.80983521823616 0.0658047175169523 no 259 0.0351606723201539 234 3312542 SGTC_530 4358-1714 28 µM 1.80209044016351 0.0666472537744505 no 260 0.0357655887685855 344 1564641 SGTC_2981 9013952 38.96 µM 1.79935764152847 0.0669465331783207 no 261 0.0359810627428379 290 2996344 SGTC_1765 st044815 90.4 µM 1.79393442979939 0.0675435274965492 no 262 0.0364118176197249 296 645695 SGTC_720 r052-1644 49.9 µM 1.79087934926924 0.0678816415828935 no 263 0.0366563291166167 254 1422863 YOR257W CDC31 SGTC_630 4356-0227 183 µM 1.78214525354869 0.0688554789786662 no 264 0.0373627738865315 254 779312 SGTC_581 0958-0271 211 µM 1.78102529129228 0.068981128144514 no 265 0.0374541595675209 376 4591145 SGTC_438 sphingosine 6.67 µM 1.77785191599874 0.0693381106812835 no 266 0.0377140896199031 238 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes. SGTC_2634 4'-methoxyflavone 100 µM 1.76884690782906 0.0703588607079209 no 267 0.0384597131413504 291 77793 From seeds of Psoralea corylifolia (Fabaceae) SGTC_1907 st060210 83.7 µM 1.76666974914311 0.0706073754050605 no 268 0.0386417761963506 331 688793 SGTC_526 4469-0568 170 µM 1.76655668831259 0.0706202992885519 no 269 0.0386512499607185 308 2901964 SGTC_830 4076-0286 57.8 µM 1.76192966770397 0.0711507711466463 no 270 0.0390405906618269 488 6866659 SGTC_2268 7933382 153.85 µM 1.75868041678302 0.0715251114497607 no 271 0.0393159027257029 373 935025 YOR257W CDC31 SGTC_752 1896-0090 130 µM 1.75744772646771 0.0716675222345435 no 272 0.0394207622160951 299 772567 SGTC_3116 9124943 49.47 µM 1.7513480305541 0.0723754137981547 no 273 0.0399429895134862 293 41905195 YPL160W CDC60 SGTC_3251 9135047 49.47 µM 1.74261738180205 0.0733979427001109 no 274 0.0407002358825089 222 17682963 SGTC_3152 9099253 49.47 µM 1.74020343564031 0.0736826035374844 no 275 0.0409116512898906 453 25236131 SGTC_517 1365-0151 113 µM 1.7379755493186 0.0739460717436371 no 276 0.0411075610863629 305 768657 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 1.73677393767665 0.0740884719702184 no 277 0.0412135405205546 313 66535 A nucleotide analog. SGTC_305 1682-2595 20.8 µM 1.73669581784737 0.0740977370184122 no 278 0.0412204381746677 299 226033 SGTC_796 1234-0020 70.7 µM 1.73254900265308 0.074590822770545 no 279 0.041587930100783 311 46495034 SGTC_3323 9138564 53.9225 µM 1.72921006881515 0.0749896626016499 no 280 0.0418857524708405 353 43912313 YNL103W MET4 SGTC_425 3825-7017 13.1 µM 1.72819518777594 0.0751112131887587 no 281 0.0419766181029833 352 3397440 SGTC_404 fumagillin 50 µM 1.72686013576902 0.0752713388504651 no 282 0.0420963926534529 335 12015870 A methionine aminopeptidase binder. SGTC_1205 4161-2785 76 µM 1.72471931268182 0.0755286514576991 no 283 0.0422890344354973 290 3498106 SGTC_2693 st077581 40.7 µM 1.72170323149984 0.0758923008488626 no 284 0.0425616458292575 404 25238761 SGTC_727 3032-0951 202 µM 1.71780769052886 0.0763639581225223 no 285 0.0429158491564867 307 3652836 SGTC_3127 9126946 49.47 µM 1.71658352354532 0.0765126352394913 no 286 0.0430276475387042 288 27243249 SGTC_2749 bexarotene 57.39 µM 1.71651816487926 0.0765205793459014 no 287 0.0430336231004412 347 82146 An retinoic acid receptor inhibitor. SGTC_3274 9138298 49.47 µM 1.71232829499464 0.0770311530865515 no 288 0.0434180925528599 335 17015756 SGTC_420 mitomycin C 81.9 mM 1.70482869587058 0.0779515063145624 no 289 0.0441131889764754 346 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_862 0452-0056 10.2 µM 1.70152548332861 0.078359514674589 no 290 0.0444221783860784 292 1575396 YLR359W | YHR072W ADE13 | ERG7 SGTC_463 ikarugamyin 104 µM 1.70051450129332 0.0784847129005728 no 291 0.0445170955440606 206 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis. SGTC_2481 5478948 45.16 µM 1.69398035677917 0.0792975497312956 no 292 0.0451345078871228 337 77792 SGTC_2113 5491891 107.031 µM 1.69044964544544 0.0797394083003849 no 293 0.0454709820184303 346 789979 SGTC_2772 vinpocetine 57.06 µM 1.68974096412301 0.0798283217712578 no 294 0.0455387612878073 338 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor. SGTC_1970 st070122 35.8 µM 1.68960023654234 0.0798459868326856 no 295 0.0455522303325309 356 102928 SGTC_503 tyrphostin 8 294 µM 1.68819905569796 0.0800220336591306 no 296 0.0456865122204193 354 92970 A tyrosine kinase inhibitor. YOR207C RET1 SGTC_1954 st077032 68.9 µM 1.68312559871868 0.0806619272282676 no 297 0.0461753899494154 304 698907 SGTC_2680 butyl paraben 22.24 µM 1.68015431108186 0.0810384732068127 no 298 0.0464636480772257 273 7184 An antifungal and steroid mimetic. SGTC_1755 st041960 45.185 µM 1.67906054941038 0.0811774172319722 no 299 0.0465701218943561 322 2257073 SGTC_2118 5526350 200 µM 1.67602018186179 0.0815645890519595 no 300 0.0468671197793646 352 743594 SGTC_1195 1502-0147 41.1 µM 1.67552785328333 0.0816274147972538 no 301 0.0469153554374597 361 817940 SGTC_2890 9046729 58.44 µM 1.6753329805858 0.0816522924581091 no 302 0.0469344589924114 298 903329 SGTC_2455 5377712 9.75 µM 1.67106958257361 0.0821979940417201 no 303 0.047353967305405 302 2243908 SGTC_3258 9138477 49.47 µM 1.67057356250148 0.0822616610259284 no 304 0.0474029690310849 310 4970355 SGTC_1812 st052057 4.327 µM 1.66903217393948 0.0824597440023388 no 305 0.0475555018512743 347 3645418 SGTC_2622 2-methoxyxanthone 59.94 µM 1.66668718817803 0.0827617852241471 no 306 0.0477883108864913 329 71034 A hepatoprotective. SGTC_2514 salinomycin 42.74 µM 1.66663324939422 0.0827687424833856 no 307 0.0477936766200381 407 23682228 A polyether potassium ionophore. SGTC_1866 st057638 64 µM 1.65981386884169 0.0836518852677879 no 308 0.0484759514165588 313 688802 SGTC_1091 telmisartan 47.6 µM 1.65347544798392 0.084479072441355 no 309 0.0491170694408437 348 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. SGTC_407 eburnamonine 100 µM 1.6467717364343 0.0853605926853145 no 310 0.0498024864138307 296 3195 SGTC_2995 9067767 71.4286 µM 1.64659906989055 0.0853833885559439 no 311 0.0498202408835987 301 11673567 SGTC_2296 7971656 126.45 µM 1.64495568155561 0.0856005810953699 no 312 0.0499894754164462 377 666570 SGTC_1902 st060212 70.5 µM 1.64455091987454 0.0856541384118868 no 313 0.050031227661368 357 688944 SGTC_2540 epiandrosterone 100 µM 1.64452277255696 0.0856578637456323 no 314 0.0500341321658668 481 441302 A steroid. SGTC_2191 5911152 200 µM 1.64125791866394 0.0860907949111343 no 315 0.0503719437068146 347 2875902 SGTC_633 0437-0093 97.7 µM 1.63827440342146 0.0864878491772522 no 316 0.0506822323767696 319 2831118 SGTC_13 0199-0087 65 µM 1.63263656371593 0.087241883405045 no 317 0.0512727282255308 353 4589825 SGTC_3232 9132874 49.47 µM 1.63059683554928 0.0875158930658501 no 318 0.0514877086669817 338 3784940 SGTC_2775 cyproheptadine 69.59 µM 1.62550071867742 0.0882032929947699 no 319 0.05202795541369 343 2913 A selective serotonin reuptake inhibitor. SGTC_1511 0906-3109 28.5 µM 1.62192729715896 0.0886876961339104 no 320 0.0524094579778835 483 2882180 SGTC_3283 9109332 35.8195 µM 1.62137449251224 0.0887628094248129 no 321 0.0524686738936632 279 17027281 SGTC_1120 ficusin 1.78878 µM 1.62130955562428 0.0887716359455276 no 322 0.0524756333567689 332 6199 A DNA cross-linker. SGTC_2881 9058953 51.95 µM 1.61661101240146 0.089412019421311 no 323 0.0529811366455063 396 17122249 SGTC_199 4063-0024 41.6 µM 1.61599266966456 0.0894965510730825 no 324 0.0530479490370837 324 306215 SGTC_1769 st044406 64.4 µM 1.61303765288065 0.0899013427952615 no 325 0.0533681638490666 389 670903 SGTC_589 1227-0070 34.1 µM 1.61125921615699 0.0901456161934389 no 326 0.0535616179736934 352 2841384 SGTC_3214 9129694 49.47 µM 1.60256095550549 0.0913474537882989 no 327 0.054515809871609 353 17158655 SGTC_3253 9135987 49.47 µM 1.60042056501964 0.0916450041756903 no 328 0.0547526579696892 320 4182430 SGTC_3194 9111903 49.47 µM 1.5915583420712 0.0928846470917376 no 329 0.0557419882910669 381 17087251 SGTC_3148 9097893 49.47 µM 1.58855707578345 0.0933072603099244 no 330 0.0560802127842515 375 17174100 SGTC_1530 rhein 70.4 µM 1.58700091511392 0.0935269443045111 no 331 0.056256218682727 390 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death. SGTC_2659 sanguinarine 24.21 µM 1.58548008462134 0.0937420095674125 no 332 0.0564286491371697 362 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. SGTC_1622 st003707 19.4 µM 1.58541781801298 0.0937508226512992 no 333 0.056435717738149 425 10140899 SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.58535045614106 0.0937603575967856 no 334 0.0564433655471022 361 2724278 An inhibitor of dopamine biosynthesis. SGTC_1096 rimcazole 32.2 µM 1.58443456455921 0.0938900713644355 no 335 0.056547430721753 335 18528119 A dopamine reuptake inhibitor. SGTC_1051 3253-3903 78 µM 1.58417939993099 0.0939262328071545 no 336 0.0565764498759529 412 5509239 SGTC_3320 9137005 35.139 µM 1.58247901025298 0.0941674712835027 no 337 0.0567701301424557 350 4908713 SGTC_2811 7967822 32.47 µM 1.56864028712175 0.0961478231372892 no 338 0.0583658897707006 408 2232244 SGTC_767 0929-0023 86 µM 1.56781776273815 0.0962664849525398 no 339 0.0584618341363046 504 1204563 SGTC_2018 5133068 143 µM 1.56613224872164 0.0965099825438357 no 340 0.0586588298863953 392 785362 SGTC_1459 k035-0031 35.7 µM 1.56493086646859 0.0966838161009324 no 341 0.0587995601558303 317 3877128 YMR208W ERG12 SGTC_1693 xanthone 101.9 µM 1.56373609943873 0.0968569204365526 no 342 0.0589397781651978 399 7020 An insecticide. SGTC_338 4055-0136 114 µM 1.55978459080351 0.0974310573082341 no 343 0.0594053970395155 400 2900563 SGTC_2714 st079313 56.9 µM 1.55738353118299 0.0977811378325102 no 344 0.0596897269156998 375 2939799 SGTC_734 2023-0417 80 µM 1.54774440729309 0.0991958287731064 no 345 0.0608419229420406 410 3935732 SGTC_2783 7738165 71.43 µM 1.54597471940516 0.0994571760033593 no 346 0.0610553367133628 309 17201110 SGTC_840 0245-0196 390 µM 1.5445843320551 0.0996628609633496 no 347 0.0612234191962827 435 3827528 SGTC_1927 st060202 13.8 µM 1.54343450713161 0.0998331933214496 no 348 0.0613626933011037 373 688887 SGTC_1962 st076595 64.5 µM 1.53993067221859 0.100353554292397 no 349 0.0617886266621213 416 279619 SGTC_1396 3511-0007 98.6 µM 1.53550429852025 0.101013749309695 no 350 0.0623300010116138 354 X1396 SGTC_2347 9049783 174.81 µM 1.53505331077808 0.101081191574822 no 351 0.0623853667595469 442 6467988 YPL169C MEX67 SGTC_1614 st002383 48.6 µM 1.53486581611893 0.101109239830216 no 352 0.0624083959232219 409 1947235 SGTC_1109 tnp00067 928.257 nM 1.53271052037711 0.101432068658111 no 353 0.0626735979456563 380 676295 SGTC_1648 st011736 69.8 µM 1.53245344414819 0.101470624626449 no 354 0.0627052888704514 385 2855514 SGTC_3218 9131285 49.47 µM 1.53143918352842 0.101622846292267 no 355 0.0628304431162368 480 17156417 SGTC_983 1491-0821 12.2 µM 1.52753239148406 0.102210736926882 no 356 0.0633143394990381 365 46495113 SGTC_1723 st034307 2.5525 µM 1.52605003842457 0.102434446300689 no 357 0.0634987016234377 395 867466 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM 1.52527968333133 0.102550844961846 no 358 0.0635946764980448 501 551469 SGTC_3289 9119912 71.43 µM 1.52473731377113 0.102632853259983 no 359 0.0636623154234671 404 17014829 SGTC_455 paf C-16 10 µM 1.52460549437797 0.102652792042115 no 360 0.0636787630761764 383 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis. SGTC_2498 4'-Methoxychalcone 54.63 µM 1.52264400092742 0.102949816994092 no 361 0.0639238975467478 395 641818 YHR062C RPP1 SGTC_2626 ethyl orsellinate 100 µM 1.52099945393975 0.103199328169724 no 362 0.0641299871760535 384 75653 A natural product. SGTC_2367 9070478 135.38 µM 1.52094857657159 0.103207054296258 no 363 0.0641363712004436 438 572802 SGTC_1286 0929-0070 131 µM 1.5208362815617 0.103224108658955 no 364 0.0641504635772944 444 1420408 SGTC_2462 5162487 171.77 µM 1.51800743661621 0.103654403631866 no 365 0.0645062619747108 411 2259986 SGTC_1727 st034309 9.9045 µM 1.51716246508398 0.10378318414154 no 366 0.0646128352096847 507 870305 SGTC_2521 angolensin 13.4 µM 1.51684467460845 0.103831648007394 no 367 0.0646529523563458 378 821428 A flavenoid. SGTC_2719 novobiocin 32.65 µM 1.51675893063783 0.103844726995358 no 368 0.0646637797934266 299 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication. SGTC_2358 9037157 4 µM 1.50945123371353 0.104963804049254 no 369 0.0655917543231935 413 2388925 SGTC_100 0086-0128 49.5915 µM 1.50413250436484 0.105783768693103 no 370 0.0662736262199389 482 93297 SGTC_161 4065-0411 162.148 µM 1.50233371200025 0.106062125504021 no 371 0.0665054731936645 501 1906281 YLR208W SEC13 SGTC_1258 0671-0043 57.1 µM 1.50199845524061 0.106114063767276 no 372 0.0665487538883864 438 4298767 SGTC_70 0141-0289 43.283 µM 1.49409940783481 0.107343111877111 no 373 0.0675748193744933 671 352408 SGTC_220 paclitaxel 373.376 µM 1.49390344354671 0.107373732745107 no 374 0.0676004291408714 349 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_1201 1889-3372 45.9 µM 1.4931421256309 0.107492754042593 no 375 0.0676999938099649 384 5392199 SGTC_2611 pyromycin 23.93 µM 1.49268037301959 0.107564988845618 no 376 0.0677604366879101 433 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release. SGTC_1223 0764-0573 147 µM 1.49246832943493 0.107598171845791 no 377 0.067788206907638 474 1609797 SGTC_2265 7929201 200 µM 1.4896493016722 0.108040026530883 no 378 0.0681582357724566 437 1265108 SGTC_224 benfluorex 43.875 µM 1.48591433188212 0.108627456080527 no 379 0.0686508911085775 296 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis. SGTC_2682 pyrogallin 40.03 µM 1.48224815771885 0.109206296329852 no 380 0.0691371384875518 478 822798 An ATP competetive kinase inhibitor. SGTC_600 1495-0418 41.6 µM 1.48191414310494 0.109259142752516 no 381 0.0691815706661611 418 5377768 SGTC_1242 0402-0103 60.1 µM 1.47980744042736 0.109592880034085 no 382 0.0694623212399028 406 432868 SGTC_2231 micatex 6.853 µM 1.47919520151149 0.109690006146599 no 383 0.0695440758333973 378 20737 An antifungal of unknown mechanism. SGTC_1491 4138-0063 26.5 µM 1.47891642495444 0.109734251970601 no 384 0.0695813264691348 381 23883227 SGTC_3093 9117344 49.47 µM 1.47762399928384 0.109939545778439 no 385 0.0697542235027264 419 24824913 SGTC_15 0266-0086 27.098 µM 1.47726345651371 0.109996864897866 no 386 0.0698025148345641 541 1712902 YIL048W NEO1 SGTC_758 0868-0029 16 µM 1.47500560465942 0.110356306008776 no 387 0.0701055183096345 434 762687 SGTC_21 0849-0113 22.993 µM 1.47169328423914 0.110885137228035 no 388 0.0705518609751496 459 1560156 SGTC_1327 1436-0082 2.18 µM 1.46796851454997 0.111481984159295 no 389 0.071056387796036 422 15992205 SGTC_3307 9126885 69.2785 µM 1.46467639397669 0.112011415531913 no 390 0.0715046141698555 482 24824909 SGTC_2883 9059145 45.46 µM 1.46427867331754 0.112075497567299 no 391 0.0715589109076939 390 16476510 SGTC_497 capsazepine 133 µM 1.46397707727195 0.112124109164498 no 392 0.0716001058207053 410 2733484 A calcium channel blocker. SGTC_489 paxilline 115 µM 1.46388210787437 0.112139419560881 no 393 0.0716130814282239 403 105008 A toxic potassium channel blocker. SGTC_557 1315-0110 16.2 µM 1.46069622534044 0.112653894607239 no 394 0.0720494127055147 444 6833801 SGTC_1365 1672-3266 55.4 µM 1.46016576022929 0.112739720668903 no 395 0.0721222615249907 472 6415873 SGTC_602 3130-1533 38.1 µM 1.45986245389255 0.112788814782966 no 396 0.0721639399738735 495 720941 SGTC_2733 amorolfine 100 µM 1.45799073416581 0.113092114955869 no 397 0.0724215485163178 295 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_1575 cyproterone acetate 48 µM 1.45621784067232 0.113379937279358 no 398 0.0726662045780525 441 9880 An androgen receptor antagonist and liver toxin. SGTC_2457 5731572 11.68 µM 1.45613534434458 0.113393342944845 no 399 0.0726776043130918 418 2865357 SGTC_343 4130-2827 29.8 µM 1.45136936362757 0.114169735603986 no 400 0.0733385179518444 477 1118244 SGTC_3260 9137109 49.47 µM 1.45083641135648 0.114256789934181 no 401 0.0734127090043938 351 17478346 SGTC_1411 3909-8223 150 µM 1.45032379486481 0.114340567134085 no 402 0.0734841233056581 456 X1411 SGTC_2587 piperic acid 92.2 µM 1.4482180436084 0.114685170078982 no 403 0.0737780399325966 422 5370536 SGTC_2317 5986382 200 µM 1.44690650162112 0.11490017503719 no 404 0.0739615559757418 437 877883 SGTC_1074 carmofur 3.8 µM 1.44376686953744 0.115416028476024 no 405 0.0744022821435727 508 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1645 Cervolide 78 µM 1.44244494778925 0.115633716865424 no 406 0.0745884457777281 417 23173 A fragrance. SGTC_1585 2',4'-dihydroxychalcone 10.4 µM 1.43999526839836 0.116037890257195 no 407 0.0749343688688113 478 5357218 A potent inhibitor of glutathione S-transferases. SGTC_884 0851-0618 334 µM 1.43671794978419 0.116580182930822 no 408 0.0753990762636255 483 9642473 SGTC_516 3992-2719 87.3 µM 1.42997103686832 0.117702236720776 no 409 0.076362665964006 415 5350887 YDR037W KRS1 SGTC_3275 9138069 49.47 µM 1.42959129087338 0.117765617285999 no 410 0.07641717829755 418 17617007 SGTC_1377 2944-0135 198 µM 1.42921511559319 0.117828425699085 no 411 0.0764712072424555 487 1894137 SGTC_1958 st076513 41.9 µM 1.42188532161919 0.11905698370746 no 412 0.0775297725128763 487 732122 YGL099W LSG1 SGTC_3099 9120367 49.47 µM 1.41938515179161 0.119478102378779 no 413 0.0778933794472982 453 24824940 SGTC_2250 alverine citrate 130 µM 1.4193337150582 0.119486777196326 no 414 0.0779008736027309 624 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1 SGTC_874 0599-0792 117 µM 1.41851239186033 0.119625353750636 no 415 0.0780206117048217 537 765305 SGTC_14 0354-0009 295 µM 1.41676690708766 0.119920234460284 no 416 0.0782755440277959 485 1713507 SGTC_3235 9132602 49.47 µM 1.41362628138943 0.120452098777456 no 417 0.0787358302438257 503 4912240 SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 1.40026186915684 0.122733927994681 no 418 0.0807174574154986 493 16623 A steroid. SGTC_2333 9017922 200 µM 1.39548100119416 0.123557525959339 no 419 0.0814354200250819 471 3163164 SGTC_849 0386-0493 241 µM 1.39523941089464 0.123599247105003 no 420 0.0814718280687847 454 726119 SGTC_1179 1021-1431 9.29 µM 1.39167611379152 0.124215752457184 no 421 0.0820102493181045 561 2840958 SGTC_748 act1.228 77.9 µM 1.38872465461191 0.12472802665433 no 422 0.0824582470704853 549 4421505 YNR035C ARC35 SGTC_1135 dihydrocapsaicin 536.708 nM 1.38823763066834 0.124812699369698 no 423 0.082532348499832 498 107982 A Capsaicinoid. SGTC_1518 st038567 90.8 µM 1.38699781968066 0.125028430925844 no 424 0.0827212138386619 426 77966 SGTC_3113 9123498 49.47 µM 1.38678878320585 0.12506482966484 no 425 0.0827530892118423 463 8897275 SGTC_1921 5740136 50 µM 1.38567897000143 0.125258201237739 no 426 0.0829224762612651 540 1774243 SGTC_2312 7706453 155.7 µM 1.38420928066767 0.125514598009943 no 427 0.0831471912211525 490 976098 SGTC_2771 fluoxetine 41.05 µM 1.38373167506154 0.125597998182418 no 428 0.083220315440787 451 3386 A selective serotonin reuptake inhibitor. SGTC_2213 7173844 200 µM 1.38140915002089 0.126004112001556 no 429 0.083576597048566 496 892728 SGTC_1352 1496-0991 99 µM 1.37920154803941 0.126390978439698 no 430 0.0839163104589332 473 3000039 SGTC_3112 9123419 49.47 µM 1.37851522983543 0.126511419255092 no 431 0.0840221344900122 528 17015854 SGTC_1486 3970-0793 4.53 µM 1.37630029134249 0.126900660319922 no 432 0.0843643413795773 490 2844330 SGTC_2319 6033012 152.6 µM 1.3761101893096 0.126934106605804 no 433 0.0843937607107051 432 847246 SGTC_1036 k216-0215 33.5 µM 1.37435222354622 0.127243691391963 no 434 0.08466618037189 554 622330 SGTC_2041 5107442 45.335 µM 1.37373421655628 0.127352649575488 no 435 0.0847621051059374 499 793005 SGTC_1311 1190-0148 100 µM 1.37345165623301 0.127402488196229 no 436 0.0848059902015067 603 1961333 SGTC_2120 5538279 151.968 µM 1.36890698888243 0.128205950755995 no 437 0.0855141754222218 482 2058197 SGTC_3193 9111931 49.47 µM 1.36837174896218 0.128300808203967 no 438 0.0855978712987659 501 17087244 SGTC_2979 9012552 45.46 µM 1.3674356369689 0.128466826993656 no 439 0.0857443992732372 439 17100905 SGTC_1397 3532-0190 20.1 µM 1.36736265000438 0.128479777443017 no 440 0.0857558316810756 414 5322280 SGTC_799 1310-0557 151 µM 1.36499881083494 0.128899695479045 no 441 0.0861267118877555 519 5354492 SGTC_2294 7971431 200 µM 1.36136876154694 0.129546397741923 no 442 0.0866985914568611 423 5741572 SGTC_1741 st038134 10.228 µM 1.36086768884533 0.129635841321325 no 443 0.086777753051717 538 1272587 SGTC_599 1935-0052 86.5 µM 1.36069416973147 0.129666825180009 no 444 0.086805178925289 521 9557311 SGTC_2580 diallyl disulphide 81.36 µM 1.36044578625058 0.129711185868596 no 445 0.0868444488904832 478 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.  SGTC_8 0354-0001 70 µM 1.35945617912573 0.129888031659815 no 446 0.0870010397141526 615 4993152 SGTC_1126 isoteolin 1.0172 µM 1.3575191943542 0.130234659664035 no 447 0.0873081494111428 504 133323 SGTC_1521 st012942 49.4 µM 1.35627253247244 0.130458090987828 no 448 0.087506235770261 553 24207259 SGTC_2910 7948405 25.97 µM 1.3556584227903 0.130568251389009 no 449 0.0876039369700486 459 2971328 SGTC_2142 5622915 118.518 µM 1.35094375268072 0.131416122199091 no 450 0.0883567256465139 460 5322196 SGTC_1831 st055328 12 µM 1.34584886230071 0.132336635540409 no 451 0.089175631792074 510 1103068 SGTC_2138 5575593 77.673 µM 1.34447002097175 0.132586518346251 no 452 0.0893982222069345 434 762213 SGTC_1840 st055363 71 µM 1.34242691549592 0.132957380875318 no 453 0.0897288062556684 449 676033 SGTC_1416 3966-0321 25.3 µM 1.34158068592797 0.133111196608513 no 454 0.0898659960146952 535 582530 YLR208W SEC13 SGTC_2727 riluzole 51.77 µM 1.33779848249281 0.133800169149332 no 455 0.0904810683551393 460 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.  SGTC_2025 5147754 141 µM 1.33750410797014 0.133853895537683 no 456 0.0905290711300132 477 315777 YLR208W SEC13 SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.32622785679398 0.135923095934565 no 457 0.0923821174004308 611 688664 SGTC_1049 3226-0134 66 µM 1.32401216568683 0.136332237691094 no 458 0.0927495021803262 554 5702385 SGTC_678 1218-2179 85.9 µM 1.3231686665545 0.136488216502904 no 459 0.0928896467552232 464 6820081 YOR116C RPO31 SGTC_1997 st073024 93.8 µM 1.31652436011299 0.137721140664451 no 460 0.0939990538635773 522 686268 SGTC_2050 5263056 171 µM 1.31474012227382 0.138053516112744 no 461 0.0942986286494762 620 763468 YGL055W OLE1 SGTC_1331 1472-0049 76.2 µM 1.31344610965913 0.138294912289704 no 462 0.0945163343999154 499 24051409 SGTC_2624 nerol 100 µM 1.31025993036994 0.138890515309107 no 463 0.0950539589002184 516 637566 A natural product oil. SGTC_1303 1160-0052 261 µM 1.3099515659825 0.138948251445831 no 464 0.0951061105123191 532 3562476 SGTC_273 hydroxyurea 18.1 mM 1.30918355854441 0.139092119172222 no 465 0.0952360900846784 606 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12 SGTC_732 3970-1727 52.7 µM 1.30774062714004 0.139362691795549 no 466 0.0954806491914509 506 1275699 SGTC_1318 1280-3875 124 µM 1.30546067215499 0.139790949154219 no 467 0.0958680151863998 560 373245 SGTC_1882 5615643 20 µM 1.30437733894519 0.13999475120849 no 468 0.0960524788628085 492 2253075 SGTC_2718 lomofungin 53.02 µM 1.30341529698848 0.140175904527019 no 469 0.0962165084388933 526 5351222 A RNA synthesis inhibitor. SGTC_1627 st003713 25.6 µM 1.30246209326615 0.140355550580663 no 470 0.0963792340674079 632 16195070 YER133W GLC7 SGTC_396 dithiazanine 1.25 µM 1.30208325929804 0.140426991124658 no 471 0.0964439626218047 510 10578 An antihelmenthic. SGTC_2320 7373003 200 µM 1.30173572945008 0.140492550044874 no 472 0.0965033705601279 521 5415828 SGTC_1424 4048-1941 275 µM 1.3016516316765 0.140508417586106 no 473 0.0965177505599684 589 X1424 SGTC_2774 tamoxifen 10.92 µM 1.30051311886162 0.140723351547502 no 474 0.0967125814539501 518 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  SGTC_1776 st049249 45.9 µM 1.30029037293696 0.14076542868324 no 475 0.096750733175725 570 1822314 SGTC_520 3584-0023 682 µM 1.30001171969068 0.140818078838929 no 476 0.0967984762140184 522 1340790 SGTC_1226 3909-7979 35.4 µM 1.29053826283079 0.142615992320386 no 477 0.0984319178515588 607 6615510 SGTC_3006 9075424 71.4286 µM 1.28943351999458 0.14282666129818 no 478 0.0986237071873043 526 7465181 SGTC_3351 9150312 21.596 µM 1.28932522274022 0.142847324362081 no 479 0.0986425228884187 557 4904905 SGTC_2497 7-hydroxyflavone 100 µM 1.28915699842389 0.142879425487274 no 480 0.0986717556032192 498 5281894 SGTC_311 1315-0136 58 µM 1.28376641089885 0.143910656950486 no 481 0.0996118497832816 564 6759207 SGTC_1324 1418-0026 34.4 µM 1.27940105543789 0.144749429563951 no 482 0.100377931193434 584 1372513 SGTC_254 nsc-64875 3.808 µM 1.27727353654955 0.145159408457725 no 483 0.10075284651969 545 56993 SGTC_1849 st056239 19.2 µM 1.27678188606552 0.145254261941326 no 484 0.100839631160007 583 5393181 SGTC_2725 haloperidol 53.21 µM 1.27578522285444 0.145446674801555 no 485 0.101015726322995 562 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_341 1486-1430 230 µM 1.27551157511435 0.145499534409555 no 486 0.101064114896875 556 2054753 YPL210C SRP72 SGTC_744 1594-0068 283 µM 1.27535748247873 0.145529305647753 no 487 0.101091370218753 620 668392 SGTC_3205 9113483 49.47 µM 1.27438184661028 0.145717896997119 no 488 0.101264061343384 606 17018033 SGTC_355 1311-2252 105 µM 1.27364606803912 0.145860232325372 no 489 0.101394438951545 573 5338538 SGTC_261 5-fluorouridine 15.376 µM 1.27030020367032 0.146508663316634 no 490 0.101988857840599 575 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_2144 5628481 200 µM 1.26973799625534 0.146617809116943 no 491 0.102088986711502 507 2818399 SGTC_84 0443-0269 128.823 µM 1.2693492995146 0.146693301806083 no 492 0.102158255220444 578 6150058 SGTC_1717 st033143 58.0435 µM 1.26796282919988 0.146962794512727 no 493 0.102405612524233 623 674616 SGTC_2478 5763493 32.33 µM 1.26664575920333 0.147219104989263 no 494 0.102640991357437 587 1365576 YLR208W SEC13 SGTC_1092 toremifene 6.32 µM 1.2651207373832 0.147516258395347 no 495 0.10291402508268 622 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_3002 9075603 71.4286 µM 1.26466750869206 0.147604648271374 no 496 0.102995270932092 586 20105405 SGTC_2241 6772625 37.8075 µM 1.25710874674991 0.149084007706744 no 497 0.104357130163649 547 2285411 SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.25638716851955 0.149225747080019 no 498 0.104487815780115 602 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM 1.25415359139669 0.149665058107814 no 499 0.104893092216526 590 4213774 SGTC_1439 4092-1168 46 µM 1.25172732983768 0.150143244083266 no 500 0.105334618966153 578 2886240 SGTC_1752 st044819 83.042 µM 1.25120934700381 0.150245463834344 no 501 0.105429054467359 572 441209 YML126C ERG13 SGTC_2380 9035439 200 µM 1.24944491191152 0.15059400893584 no 502 0.10575119517542 628 6462575 SGTC_3280 9140961 49.47 µM 1.24832545685257 0.15081542419635 no 503 0.105955947624813 549 4901226 SGTC_1045 1348-1485 165 µM 1.248232966516 0.150833727402732 no 504 0.105972877251431 632 6810614 SGTC_831 k061-1017 217 µM 1.243013932426 0.151868934719516 no 505 0.106931349709232 763 1240153 SGTC_531 3788-1495 174 µM 1.24054927883914 0.152359441482809 no 506 0.107386149530927 584 2896655 SGTC_2019 4016004 108 µM 1.23935824224236 0.152596853881725 no 507 0.107606429237226 533 45595336 SGTC_1443 4112-3303 14 µM 1.23523116054 0.153421413570605 no 508 0.108372242671064 605 704433 SGTC_230 MPP+ 141.667 µM 1.2333210342364 0.15380403958579 no 509 0.108728006621542 569 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death. SGTC_1762 st045503 25.4615 µM 1.23096587523257 0.154276680892249 no 510 0.109167813783141 606 4645554 SGTC_1437 4092-1038 11.6 µM 1.22523864460059 0.15543004478592 no 511 0.110242659019022 630 3977136 SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 1.22502560786484 0.155473056118116 no 512 0.110282786111279 519 4620898 SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.22478119735437 0.155522411371575 no 513 0.110328835593865 630 5393153 SGTC_3209 9113616 49.47 µM 1.22463343329945 0.155552255250159 no 514 0.110356682566036 647 16649353 SGTC_1904 st060225 78 µM 1.22420807264427 0.15563818635116 no 515 0.110436872323148 587 66595 SGTC_2652 actinonin 100 µM 1.22161343702473 0.156163030920988 no 516 0.110926922416897 572 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase. SGTC_1441 4106-0040 13 µM 1.21978783665007 0.156533012649935 no 517 0.111272656763855 580 2904180 SGTC_176 1486-1328 72.834 µM 1.2146430214309 0.157578779116906 no 518 0.112251136454079 629 22310231 SGTC_55 0767-0285 6.563 µM 1.21456637450141 0.157594393463485 no 519 0.112265760084268 643 3116166 SGTC_354 2783-3500 4.88 µM 1.2138629829476 0.157737734338889 no 520 0.112400025230197 605 6740761 SGTC_1515 3460-0031 42.1 µM 1.21310329550431 0.157892643654881 no 521 0.11254516510096 527 2876596 SGTC_2674 ligustilide 100 µM 1.21304022886035 0.157905508183927 no 522 0.11255722013005 563 5319022 A signalling regulator. SGTC_974 1326-0144 138 µM 1.21207191250935 0.158103114755004 no 523 0.112742427148051 630 5411856 SGTC_3 0833-0587 95.581 µM 1.21143748375289 0.158232672083496 no 524 0.112863890398101 597 5382644 SGTC_208 k072-0098 12.366 µM 1.21072625610903 0.15837799539495 no 525 0.113000168052576 704 5948901 SGTC_3098 9119039 49.47 µM 1.2096591171387 0.158596205345568 no 526 0.113204861771165 608 17161528 SGTC_1056 3448-1962 115 µM 1.20776014162772 0.158984997635775 no 527 0.113569768530458 593 715507 SGTC_117 lucigenin 22.078 µM 1.20726922706268 0.159085607969515 no 528 0.113664238851833 668 65100 An acridine derivative; a dye stuff and potential carcinogen. SGTC_2865 9030313 51.95 µM 1.20640656313443 0.159262507389599 no 529 0.1138303833401 559 42562754 SGTC_3115 9123671 49.47 µM 1.20613593301003 0.159318029826681 no 530 0.11388254091068 623 3286988 SGTC_1154 4088-0362 150 µM 1.20587532720717 0.159371507653473 no 531 0.113932782623277 685 6618304 SGTC_1881 5652484 16 µM 1.20491349067181 0.159568983834671 no 532 0.114118350023257 605 2255129 SGTC_1539 benzyladenosine 56 µM 1.20391956311338 0.1597732168581 no 533 0.114310334827701 592 92208 A nucleotide analog. SGTC_2168 5727979 200 µM 1.20350315684722 0.159858831158084 no 534 0.114390835242405 557 695210 SGTC_2849 9019321 12.99 µM 1.20336115037756 0.159888034948565 no 535 0.114418297417604 577 16489627 SGTC_2996 9066192 71.4286 µM 1.20135576819951 0.160300816626843 no 536 0.114806613068931 606 6472854 SGTC_2151 5563267 85.4165 µM 1.19793748366855 0.16100602973697 no 537 0.115470677893533 641 5310824 SGTC_3213 9129884 49.47 µM 1.19439107804526 0.161739811831253 no 538 0.116162512603197 534 17190742 SGTC_856 0433-0016 11.3 µM 1.19286686785524 0.162055852734506 no 539 0.116460758437001 651 3911780 SGTC_54 0159-0055 9 µM 1.18925897035126 0.162805542305053 no 540 0.117168887753905 619 3319099 SGTC_850 0388-0143 75.9 µM 1.18922222927209 0.162813188362988 no 541 0.11717611465493 607 67273 SGTC_262 fenpropimorph 62.5 µM 1.18919582060315 0.16281868432329 no 542 0.117181309385394 579 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes.  YDL196W YDL196W SGTC_330 1488-0319 80.1 µM 1.18560499261208 0.163567102068377 no 543 0.117889164843258 640 6846614 SGTC_598 3937-0236 20.2 µM 1.18241192463523 0.164234490146741 no 544 0.118521146964327 698 1379313 SGTC_1931 st074438 57.1 µM 1.18127807527713 0.164471902019408 no 545 0.118746137046132 609 2787313 SGTC_1699 st031318 29.054 µM 1.18031689856421 0.164673332831203 no 546 0.118937099800533 634 5340658 SGTC_2261 9010538 184.68 µM 1.17983038565685 0.164775350728121 no 547 0.119033840868084 550 6457250 SGTC_2679 rapamycin 1 nM 1.17803164538139 0.165152887711737 no 548 0.11939199527641 731 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2 SGTC_3312 9133330 71.43 µM 1.17800641024992 0.165158188284551 no 549 0.119397025347823 688 17617324 SGTC_2446 5162541 200 µM 1.17346389511615 0.166114125425394 no 550 0.120304913647232 609 1549321 SGTC_2023 5144124 124 µM 1.16981996788296 0.166883540303509 no 551 0.121036713136328 639 2830192 SGTC_912 3474-0017 2.18 µM 1.16897807220267 0.167061632893941 no 552 0.121206233075483 659 3360550 SGTC_842 0271-0008 11.1 µM 1.16816307845202 0.167234151410197 no 553 0.12137049517624 699 1221709 SGTC_3224 9130643 49.47 µM 1.16339328470494 0.168246126827675 no 554 0.12233498643195 623 17644395 SGTC_3091 9116372 49.47 µM 1.16212868707853 0.168515087379024 no 555 0.122591598172077 594 17169793 SGTC_1709 st033179 39.1045 µM 1.1606930380715 0.168820762801712 no 556 0.122883377034987 678 573381 SGTC_1430 4049-0248 69.1 µM 1.16002120269064 0.168963930898563 no 557 0.123020086843254 721 22774488 SGTC_539 4859-0462 2.54 µM 1.15962408129409 0.169048594118484 no 558 0.123100946030057 658 46499474 YNL221C | YBR257W POP1 | POP4 SGTC_1735 st034310 56.75 µM 1.15705479704901 0.169597003910802 no 559 0.123624986580604 655 871153 SGTC_755 1995-0008 37.3 µM 1.15573805714435 0.169878501879146 no 560 0.123894158245178 685 689533 SGTC_265 mycophenolic acid 32.932 µM 1.15424056359527 0.170199005950479 no 561 0.124200778297541 709 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1 SGTC_144 4161-2749 112.381 µM 1.15378556772325 0.170296464052989 no 562 0.124294046266652 579 797501 YMR168C CEP3 SGTC_2555 cholic acid 100 µM 1.15257880534843 0.170555120324687 no 563 0.124541653372252 651 6708657 Influences liver metabolism. SGTC_868 0527-0199 213 µM 1.15211663389815 0.170654248284199 no 564 0.124636574352915 681 2849450 SGTC_1514 1189-1591 158 µM 1.15102832971464 0.170887816768816 no 565 0.124860290458271 697 767698 YMR146C TIF34 SGTC_218 alverine citrate 93.75 µM 1.15022835425384 0.171059635406569 no 566 0.125024915388779 631 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1408 3909-7976 48.8 µM 1.1450321775735 0.172178358158462 no 567 0.126097914152244 712 24152374 SGTC_1638 st008370 60.6 µM 1.14459318519523 0.172273085447924 no 568 0.126188858293248 669 24207134 SGTC_2928 9011484 9.79 µM 1.14368487478932 0.172469189356172 no 569 0.126377174140996 611 2994751 SGTC_1722 st034304 3.6505 µM 1.14114459226846 0.173018391022828 no 570 0.126904878615512 677 4036148 YLR033W RSC58 SGTC_2556 citropten 84.59 µM 1.14045375301924 0.173167940938825 no 571 0.127048654719814 708 2775 A potential DNA crosslinker. SGTC_1332 1480-0653 17.5 µM 1.13577857014901 0.174182167205772 no 572 0.12802462398438 662 5749438 SGTC_778 3456-2434 196 µM 1.13478777262148 0.174397593002874 no 573 0.128232125312698 765 5539063 SGTC_2956 9076196 2.52 µM 1.1343837520789 0.174485486400486 no 574 0.128316805763286 672 16423868 SGTC_838 0109-0203 71.4 µM 1.1330923611453 0.17476661308201 no 575 0.128587734454903 697 759422 SGTC_1600 coumarin 106 71.1 µM 1.13175070564179 0.175058986352345 no 576 0.128869628649511 699 100336 A hepatotoxic, DNA x-linker. SGTC_2598 perillyl alcohol 100 µM 1.13005833693602 0.175428229261314 no 577 0.129225821895571 700 10819 An apoptosis inducer. SGTC_708 3448-5400 146 µM 1.12733164097707 0.176024180545246 no 578 0.129801144679345 707 3462195 SGTC_1719 st032227 49.2 µM 1.12670731629916 0.176160814139952 no 579 0.129933124042255 655 3125804 SGTC_3306 9127676 59.7925 µM 1.126537788567 0.176197926907841 no 580 0.129968977456675 642 41905287 SGTC_1440 4100-1550 40 µM 1.12382869806908 0.176791668382241 no 581 0.130542852185793 667 742806 SGTC_3079 9117512 49.47 µM 1.12122904943581 0.177362611551994 no 582 0.131095188749674 735 7185044 SGTC_1896 st058441 89 µM 1.12111510424129 0.177387663163979 no 583 0.131119435088676 625 688759 SGTC_2022 5136654 200 µM 1.12109917846837 0.177391164729443 no 584 0.13112282417238 672 1713771 SGTC_282 k297-0036 65.7 µM 1.12097740071887 0.177417941184106 no 585 0.131148741083679 638 5061378 SGTC_3330 9141424 71.43 µM 1.1198196061328 0.177672644146461 no 586 0.131395321293015 732 27261020 SGTC_613 3914-0030 117 µM 1.11825249223337 0.178017760456634 no 587 0.131729585453131 440 1145395 SGTC_3248 9135562 49.47 µM 1.11825223326209 0.17801781752327 no 588 0.131729640739947 736 17650701 SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.11775949190712 0.178126418372507 no 589 0.131834863256847 667 6708514 SGTC_219 mitoxanthrone 164.414 µM 1.11733289445823 0.178220474740697 no 590 0.131926007883396 666 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA.  YMR168C CEP3 SGTC_1986 st071812 45 µM 1.11568147217535 0.178584876007207 no 591 0.132279252059507 646 11838594 SGTC_2817 7995342 71.43 µM 1.11532512941395 0.178663567767938 no 592 0.132355560285343 597 18879975 SGTC_3016 9080866 49.47 µM 1.11477589941576 0.178784897888964 no 593 0.132473233326276 719 17066299 SGTC_631 k072-0230 41.5 µM 1.11412666140562 0.178928387608161 no 594 0.132612426126768 737 5773147 SGTC_1082 camptothecin 424.86 nM 1.11230176313695 0.179332100970459 no 595 0.133004213030896 610 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1123 mangostin 811.285 nM 1.10744174326733 0.180410050617415 no 596 0.13405149328232 667 5281650 An antioxidant. SGTC_726 3448-4391 34.2 µM 1.10523481944867 0.180900884340177 no 597 0.134528926457787 755 1356692 SGTC_2316 5844804 197.44 µM 1.10469191984442 0.181021756769415 no 598 0.13464655289981 839 776813 SGTC_2868 9035608 32.47 µM 1.10184096309157 0.181657330712043 no 599 0.13526540916422 693 6462614 SGTC_1175 0741-0056 27.6 µM 1.09856146485855 0.182390165579456 no 600 0.135979696932124 778 765927 SGTC_3138 9097216 49.47 µM 1.09838304040988 0.182430089116325 no 601 0.136018632418348 688 25237486 SGTC_89 0302-0250 142.109 µM 1.096322187719 0.18289161283922 no 602 0.136468901438583 754 4203518 YLR208W SEC13 SGTC_1046 2001-0062 216 µM 1.09529666814787 0.183121547126643 no 603 0.136693343363242 700 739778 SGTC_931 2812-0076 566 µM 1.09488505076864 0.183213887573008 no 604 0.136783499561264 739 3450959 SGTC_653 0203-0016 55.2 µM 1.09451050076789 0.183297937716309 no 605 0.136865572238725 720 295302 SGTC_1463 k081-0032 34.1 µM 1.09370744711941 0.183478226386548 no 606 0.137041653529962 586 977755 SGTC_2796 7949634 45.45 µM 1.0907655614486 0.184139634870905 no 607 0.137688026884544 666 2971588 SGTC_3041 9091929 49.47 µM 1.09035069135871 0.184233027161512 no 608 0.137779346753753 740 25236887 SGTC_3051 9093778 49.47 µM 1.08906615898775 0.184522377869109 no 609 0.138062355915613 645 17217378 SGTC_2927 9011802 47.9 µM 1.08864821544044 0.18461658374756 no 610 0.138154522980248 687 43912568 SGTC_1134 3477-0009 42.5 µM 1.08813433462252 0.184732455193288 no 611 0.138267904118925 771 3973534 SGTC_1822 st052468 42 µM 1.08690773428325 0.185009215553976 no 612 0.138538793932938 682 2873678 SGTC_1375 2910-0797 186 µM 1.08544733684344 0.185339063787686 no 613 0.138861788195501 717 742508 SGTC_1550 gossypolone 36.6 µM 1.08239881680487 0.186028784181367 no 614 0.139537676907225 738 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_3117 9124945 49.47 µM 1.0820211073375 0.186114350701595 no 615 0.139621574553743 643 17592065 SGTC_938 3126-1755 342 µM 1.0804209441194 0.186477123126939 no 616 0.139977386711885 769 1777771 SGTC_1783 st039459 87.517 µM 1.0800387464664 0.186563835771068 no 617 0.140062463232965 782 729761 SGTC_174 3553-0389 74.3 µM 1.07911743949138 0.186772963648092 no 618 0.140267688929073 658 738071 SGTC_1879 gemcitabine 100 µM 1.07851230596013 0.186910402093938 no 619 0.140402596495526 734 60750 A nucleoside analog which inhibits DNA replication. SGTC_3240 9133527 49.47 µM 1.0774683269509 0.187147658567646 no 620 0.140635546667173 708 17617455 SGTC_1432 4049-0298 68.4 µM 1.07729891870437 0.187186176135689 no 621 0.140673372610307 709 741646 SGTC_2056 5235370 200 µM 1.07722266002834 0.187203516317502 no 622 0.140690402112373 688 5511916 SGTC_251 melphalan 456.522 µM 1.07642344452813 0.187385306764116 no 623 0.140868960946505 816 460612 A DNA alkylator. SGTC_1279 0874-0590 65.2 µM 1.07632372558715 0.187407996600081 no 624 0.140891250699327 755 3523074 SGTC_88 0180-0332 8.668 µM 1.07531924039656 0.187636649728789 no 625 0.141115912459465 728 3101745 SGTC_775 4577-0580 57.3 µM 1.07368664847903 0.188008647671869 no 626 0.141481573709875 734 2006902 SGTC_2643 anethole 100 µM 1.07348178009473 0.188055360552307 no 627 0.141527504590879 773 637563 An anti-fungal, anti-helmenthic and channel blocker. SGTC_1935 st074532 41.6 µM 1.07229936974313 0.188325106758848 no 628 0.141792794888098 816 2829742 SGTC_2903 5923464 63.88 µM 1.07191741381466 0.188412294293691 no 629 0.141878563961985 709 2876576 SGTC_1163 k060-0048 49.9 µM 1.06878107512978 0.189129154818848 no 630 0.142584164416299 773 6809982 SGTC_676 falcarinol 140 µM 1.06812431481745 0.189279480342579 no 631 0.142732219592901 757 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer. SGTC_1549 4'-methoxyflavonol 74.6 µM 1.06666103355035 0.189614674447278 no 632 0.143062464510911 742 97141 SGTC_1087 pterostilbene 9.05 µM 1.06640392437833 0.189673608187897 no 633 0.143120544227531 762 5281727 Similar to reservatol, lowers cholesterol. SGTC_2372 9071633 200 µM 1.0645994483528 0.190087541351869 no 634 0.143528614787841 804 21321366 SGTC_2210 7115885 190.385 µM 1.0634974960133 0.190340593701809 no 635 0.143778200062149 768 2927039 SGTC_1703 st026983 48.3 µM 1.06227784757217 0.190620914903384 no 636 0.144054783988662 790 1104023 SGTC_2736 butenafine 14.65 µM 1.06047210827416 0.191036406942831 no 637 0.144464936238732 781 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_2020 4017018 200 µM 1.05734601308343 0.191757018441852 no 638 0.145176850353347 735 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope. SGTC_1839 st053978 48 µM 1.05280532285064 0.192806675129055 no 639 0.146215112461575 742 3788398 SGTC_2656 pseudo-anisatin 100 µM 1.05020334792178 0.19340974419211 no 640 0.146812315310799 748 6708809 A neurotoxin. SGTC_93 0109-0045 59.227 µM 1.04983235713668 0.193495823703169 no 641 0.146897597868039 877 88733 SGTC_584 0986-0246 15.4 µM 1.04973637798969 0.193518097166007 no 642 0.146919666755438 818 53315 YDR232W HEM1 SGTC_1661 st013063 9.66 µM 1.04722787885852 0.194100788081247 no 643 0.147497245047337 813 721395 SGTC_1384 3089-0840 101 µM 1.04701010827123 0.194151423658082 no 644 0.147547458076115 718 1069836 SGTC_970 1315-0089 19.5 µM 1.04469028245033 0.19469132411553 no 645 0.148083068757739 719 6811083 YLR033W RSC58 SGTC_1247 0448-0043 5.84 µM 1.04420617192931 0.194804107790447 no 646 0.148195006030292 787 3089013 YGL099W LSG1 SGTC_1484 3473-2379 286 µM 1.04259143658199 0.195180581414833 no 647 0.148568778519493 887 671917 SGTC_50 0929-0078 56.389 µM 1.04203854736842 0.195309588428541 no 648 0.148696903838662 717 1377751 SGTC_1235 benzylparaben 21.5 µM 1.04102404402749 0.195546439716222 no 649 0.148932194640301 713 7180 SGTC_2513 baicalein 25.65 µM 1.03879652978605 0.196067098469785 no 650 0.149449687813936 743 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2 SGTC_3122 9126309 49.47 µM 1.0385870325313 0.196116109540359 no 651 0.149498419613929 769 17591206 SGTC_871 0574-0004 149 µM 1.03552533746006 0.196833228710723 no 652 0.150211819930935 796 9551173 SGTC_159 3970-0959 50 µM 1.03435832310697 0.197106987643346 no 653 0.150484340230771 957 6615653 SGTC_2959 9079155 11 µM 1.03368426410077 0.197265213734386 no 654 0.150641895939772 703 16189457 SGTC_2010 4012422 159 µM 1.03217863440618 0.197618917001111 no 655 0.150994221020811 774 952393 SGTC_2785 7756463 72.73 µM 1.03087909239262 0.197924514066499 no 656 0.151298761117044 750 2201551 SGTC_3348 9149464 3.537 µM 1.03061215905469 0.197987320766578 no 657 0.151361365929476 758 1951442 SGTC_2573 2',4'-dihydroxychalcone 15.04 µM 1.02888835961046 0.198393203028441 no 658 0.151766069465312 849 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_1485 3909-9022 254 µM 1.02812361914506 0.198573427904781 no 659 0.151945840803238 791 714516 SGTC_1165 k072-0275 30.3 µM 1.02602044470674 0.199069587868421 no 660 0.152440973656587 766 6153523 YGL055W OLE1 SGTC_3310 9130229 44.1445 µM 1.02542531615752 0.199210120133595 no 661 0.152581273964974 753 7761258 SGTC_3355 9151058 44.0485 µM 1.02441494246446 0.199448844211128 no 662 0.15281966357872 757 17015728 SGTC_336 4111-0029 111 µM 1.02336324788513 0.199697514134509 no 663 0.153068064747861 712 3131175 SGTC_1667 st014849 34.6 µM 1.02303651607427 0.199774806819529 no 664 0.153145290436175 805 5348460 SGTC_2238 6671620 73.2395 µM 1.02263296693761 0.199870296483722 no 665 0.153240708152726 748 729941 SGTC_2467 5474540 200 µM 1.02221886315891 0.199968312167265 no 666 0.153338662419761 776 5413519 SGTC_2663 amphotericin b 100 µM 1.01958141808652 0.200593256290912 no 667 0.153963510708598 738 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_359 0081-0058 15.9 µM 1.01840405749439 0.20087261073561 no 668 0.154242987371983 713 3494159 SGTC_1685 st024049 53.0905 µM 1.01644089346306 0.201338932988518 no 669 0.154709740263766 755 1941139 SGTC_3134 9127454 49.47 µM 1.01634332592451 0.201362125711512 no 670 0.154732961793353 810 24262820 SGTC_1850 st056238 17 µM 1.01530673573062 0.20160863183586 no 671 0.154979817298842 831 5393177 SGTC_2185 6113692 200 µM 1.01524251363867 0.201623910102355 no 672 0.154995119817727 720 874150 SGTC_1609 st001574 46.4 µM 1.01470959363614 0.201750717121895 no 673 0.155122139823047 787 3960012 SGTC_68 0986-0284 82.829 µM 1.01435045236412 0.201836200847509 no 674 0.155207778902073 653 423278 YIL048W NEO1 SGTC_2240 6690706 185.951 µM 1.00855945737231 0.203217580295212 no 675 0.156592979630688 672 805876 SGTC_1835 st008666 49.2 µM 1.00851516974424 0.203228166327955 no 676 0.156603604453863 679 690455 SGTC_3050 9093513 49.47 µM 1.00538444843931 0.203977333608454 no 677 0.157355882666634 806 25236664 SGTC_3327 9140648 26.9345 µM 1.00199295074566 0.204790757506028 no 678 0.158173498731315 784 8029710 SGTC_59 0330-0160 1.33 µM 0.99928107648439 0.205442565001081 no 679 0.158829274906806 917 4293482 SGTC_1820 st053765 18.6 µM 0.998266414729716 0.205686758499358 no 680 0.159075094414615 761 3690829 SGTC_1664 st014217 9.02 µM 0.996565468405109 0.206096502857422 no 681 0.159487737171262 892 3982782 SGTC_1529 apigenin 74 µM 0.995865479983924 0.206265264940816 no 682 0.159657754884115 805 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_2284 7945075 39.21 µM 0.995164493589349 0.206434349684928 no 683 0.159828133804555 893 1245402 SGTC_916 4466-0038 42 nM 0.994461559024968 0.206603986784657 no 684 0.159999105632636 927 5722064 YGL116W CDC20 SGTC_96 0929-0093 37.281 µM 0.994258179858335 0.206653083066602 no 685 0.160048594994991 775 6991579 SGTC_2793 7325131 81.82 µM 0.991340827886217 0.207358099795941 no 686 0.160759591603112 780 4176441 SGTC_3285 9112818 20.8695 µM 0.988861469325776 0.207958385941245 no 687 0.161365462232387 860 17017947 YPR165W RHO1 SGTC_975 1335-0046 28.5 µM 0.988790691975355 0.207975537141175 no 688 0.161382779636227 800 16486740 SGTC_17 0960-0276 49.807 µM 0.982581577164405 0.209483415502796 no 689 0.162906707597223 833 6821114 SGTC_1662 st014054 52 µM 0.98096104724427 0.209878015659205 no 690 0.16330597544687 798 2838777 SGTC_291 SEC14.278 35.5 µM 0.98090012393612 0.209892859043037 no 691 0.163320998184414 837 1068044 SGTC_900 1112-0045 141 µM 0.980863722705812 0.209901728150596 no 692 0.163329974588504 701 56211 YIL048W NEO1 SGTC_1295 1013-0063 9.78 µM 0.980727695472368 0.209934872940363 no 693 0.16336352122037 854 6826038 SGTC_206 4546-0025 72.014 µM 0.980454840991927 0.210001366725606 no 694 0.163430825273752 869 6620745 YIL048W NEO1 SGTC_2071 5230951 39.92 µM 0.97960285901499 0.210209071708722 no 695 0.163641096566028 873 1799272 SGTC_2801 7907800 81.82 µM 0.978635166143624 0.210445132176775 no 696 0.163880138549621 815 6620925 SGTC_2878 9043973 25.97 µM 0.9769129211026 0.210865643942955 no 697 0.164306132180973 795 6465167 SGTC_2258 7960471 200 µM 0.976631102091269 0.21093450113174 no 698 0.164375907806649 718 2974708 SGTC_94 0334-0113 514.748 µM 0.975237542371523 0.211275185028297 no 699 0.164721221846776 842 6795178 SGTC_538 2922-0838 53.3 µM 0.973837566989692 0.211617761736613 no 700 0.165068598508249 913 777039 SGTC_1264 0783-0040 158 µM 0.971670980825129 0.212148570108128 no 701 0.165607128951964 792 2855798 SGTC_2012 4023501 200 µM 0.970709901882967 0.212384281142097 no 702 0.165846379801072 754 3477460 SGTC_2604 4'-hydroxychalcone 11.32 µM 0.970132786072359 0.212525896157125 no 703 0.165990154233731 780 5282362 SGTC_3227 9130768 49.47 µM 0.970078787067101 0.212539149473044 no 704 0.166003610898073 867 17720899 SGTC_2897 9048598 12.99 µM 0.969358312147586 0.212716026355265 no 705 0.16618322219202 792 6467404 SGTC_1670 st016595 4.04 µM 0.962681222460057 0.21435933903182 no 706 0.167853761418428 862 597879 SGTC_1387 3342-1166 1.8 µM 0.961763843382905 0.214585692622267 no 707 0.16808412207158 771 3418228 SGTC_2458 5808907 16.39 µM 0.961245110670596 0.21471374590437 no 708 0.168214469678535 910 2731747 SGTC_2276 7947513 42.08 µM 0.960511411738584 0.214894941101321 no 709 0.168398945188757 766 2105100 SGTC_1602 st001878 87.6 µM 0.958993722677483 0.215270033222623 no 710 0.168780953767763 849 595405 YLR310C CDC25 SGTC_2695 st077686 51.995 µM 0.958765720056114 0.215326416169006 no 711 0.168838391039885 796 2876092 SGTC_1895 st058434 18.3 µM 0.957899870384072 0.215540610854087 no 712 0.169056625915894 875 5393175 SGTC_851 0394-0702 453 µM 0.955463874589108 0.216143892183362 no 713 0.169671582853922 896 762646 SGTC_3198 9112019 49.47 µM 0.955031067181643 0.216251180387535 no 714 0.169780993198554 831 45595555 SGTC_1361 1608-0041 5.61 µM 0.954158169717194 0.216467655859929 no 715 0.17000179249283 856 X1361 SGTC_891 0929-0073 133 µM 0.953414416267045 0.21665220297653 no 716 0.170190069988259 859 5603632 SGTC_3020 9089140 49.47 µM 0.952535481299424 0.216870409878535 no 717 0.170412740187095 834 17217859 SGTC_2726 cimetidine 79.27 µM 0.952203487472591 0.21695286466029 no 718 0.170496896338954 803 2756 A P450 inhibitor, histamine H2-receptor antagonist. SGTC_1747 st037496 66.6 µM 0.95179025598522 0.217055521130699 no 719 0.170601682360657 872 723305 SGTC_1737 st035557 69.7 µM 0.951352728350019 0.217164243925135 no 720 0.170712674255993 722 5716916 SGTC_3273 9137859 49.47 µM 0.948557583626456 0.217859561453811 no 721 0.171422836317429 865 2377234 SGTC_1118 chelidonine 707.474 nM 0.947870900896405 0.218030576247379 no 722 0.171597590218802 915 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor. SGTC_957 1187-1561 14.1 µM 0.945633542051742 0.218588315497047 no 723 0.172167764985866 841 1538454 SGTC_3146 9095609 49.47 µM 0.944569502307319 0.218853852233889 no 724 0.1724393515815 842 17173999 SGTC_1094 duloxetine 25.4 µM 0.944390777547458 0.218898472138937 no 725 0.172484996261771 846 60834 A selective serotonin reuptake inhibitor. SGTC_892 0929-0076 29 µM 0.942909290979707 0.219268537209109 no 726 0.172863651096388 873 5751038 SGTC_2264 7948757 110.76 µM 0.942558445724223 0.219356228553911 no 727 0.172953401556293 822 2971411 SGTC_992 3909-8734 162 µM 0.942364294806493 0.219404763893385 no 728 0.173003080468057 843 4288319 SGTC_1633 st005664 67.9 µM 0.941964461299064 0.219504736784346 no 729 0.173105417626531 872 2063822 SGTC_142 0335-0849 62.6745 µM 0.940337772075242 0.219911737831107 no 730 0.173522165250036 951 3889043 YPR107C YTH1 SGTC_2181 6316240 54.2555 µM 0.938758363491427 0.220307323212416 no 731 0.173927410285778 811 12779990 SGTC_44 0929-0055 61.211 µM 0.935156960560309 0.221210869983884 no 732 0.1748537076606 794 1379590 SGTC_200 k038-0079 37.545 µM 0.934565690665961 0.22135941449919 no 733 0.175006083668606 858 3436683 SGTC_2706 st078239 82.5 µM 0.934199939378141 0.221451330607262 no 734 0.175100383500269 868 15434492 SGTC_721 1187-1332 279 µM 0.933218615101933 0.221698052718612 no 735 0.175353552668947 779 25730 SGTC_368 fentichlor 4.58 µM 0.93298991905215 0.221755573468846 no 736 0.175412586666537 787 7329 A pesticide. SGTC_1218 1348-1416 30.7 µM 0.931077952546915 0.222236797401199 no 737 0.175906621186557 877 6787668 SGTC_2418 pentamidine 31.67 µM 0.930960885287682 0.222266281472848 no 738 0.175936898888205 818 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_1574 spiramycin 23.7 µM 0.930958987134955 0.222266759552063 no 739 0.175937389844302 876 6419898 An antibiotic and protein synthesis inhibitor. SGTC_3040 9091894 49.47 µM 0.92957797299248 0.222614744860623 no 740 0.17629481826766 798 25236966 SGTC_1848 st056003 16.4 µM 0.929244440676059 0.222698834237079 no 741 0.176381210574612 950 146492 SGTC_2850 9015429 58.44 µM 0.928802196857367 0.222810359611616 no 742 0.176495802879937 827 6457570 SGTC_1012 4112-3522 18 µM 0.924757973579802 0.223831709894218 no 743 0.177545907942939 922 3112398 SGTC_1868 st057644 42.7 µM 0.924430313835236 0.223914575247681 no 744 0.177631158956611 948 688665 SGTC_1502 4534-4282 27.7 µM 0.922401335317101 0.224428093218432 no 745 0.178159636757981 855 3278949 SGTC_1006 4099-6547 255 µM 0.91817983000221 0.22549866101249 no 746 0.179262363257526 888 3146833 SGTC_688 0527-0193 473 µM 0.915575453315849 0.226160566394159 no 747 0.179944805410941 870 4007154 SGTC_3121 9125696 49.47 µM 0.914727182296087 0.226376392267536 no 748 0.180167435294625 914 1235365 SGTC_1037 k284-1091 78.7 µM 0.913587657003399 0.226666505067863 no 749 0.180466777257583 833 3334711 SGTC_1366 1683-0113 21.9 µM 0.913383593703429 0.226718479876039 no 750 0.180520415576205 887 708623 SGTC_2759 disulfiram 3.38 µM 0.911821127306455 0.227116662004322 no 751 0.180931443351101 854 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_2534 helenine 20.12 µM 0.911721876884692 0.227141968494088 no 752 0.180957572303838 847 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58 SGTC_2062 5245942 200 µM 0.910540524094773 0.227443307301489 no 753 0.181268760206268 982 1376160 SGTC_731 3966-0296 387 µM 0.909680135904926 0.227662916286383 no 754 0.181495611503842 896 660956 SGTC_334 1502-1024 68.5 µM 0.907528373887272 0.228212663038738 no 755 0.182063725965663 926 3296216 SGTC_3053 9095903 49.47 µM 0.907004865601404 0.228346525268864 no 756 0.182202112115278 941 17174018 SGTC_71 0417-1750 47.813 µM 0.905092797591612 0.228835820033853 no 757 0.182708113729706 936 6811472 SGTC_3003 9075612 71.4286 µM 0.90455961699551 0.228972364846032 no 758 0.182849368681757 878 6501993 SGTC_1504 k297-0033 30 µM 0.903116179576893 0.229342251069596 no 759 0.183232118906591 783 4388117 SGTC_421 streptovitacin 30 mM 0.902103587255005 0.229601931411879 no 760 0.183500921736088 929 91467 include heat shock SGTC_2508 celastrol 40.54 µM 0.901396063939779 0.229783474206324 no 761 0.183688886716725 857 122724 Celastrol is a natural product and antioxidant. SGTC_1444 4112-3581 28 µM 0.901187682550257 0.229836957925054 no 762 0.183744269454364 938 2877249 SGTC_2670 beta-carotene 100 µM 0.900038621689288 0.230132004071737 no 763 0.18404984886352 867 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.) SGTC_2889 9059656 51.95 µM 0.899982223299885 0.230146491027395 no 764 0.184064855502291 948 3949838 SGTC_1964 st076914 61 µM 0.899365015108656 0.23030506555472 no 765 0.184229133737298 950 24208661 SGTC_2933 9026794 32.47 µM 0.898772731897051 0.230457293730736 no 766 0.184386863619365 914 17586027 SGTC_1360 1598-0022 39.8 µM 0.896989510481101 0.230915955357482 no 767 0.184862257165444 984 761525 SGTC_1060 3448-7350 82 µM 0.896341990135266 0.23108262984388 no 768 0.185035069622757 896 570178 SGTC_66 0109-0187 42.4 µM 0.894835977495222 0.231470543451346 no 769 0.18543738746782 828 759417 SGTC_3250 9135583 49.47 µM 0.892538701036972 0.232062966793043 no 770 0.186052129330378 894 7699353 SGTC_914 3820-6779 408 µM 0.889039579694308 0.232966942596364 no 771 0.186990904379456 930 2893481 SGTC_903 1134-0042 114 µM 0.888075816515768 0.233216267790083 no 772 0.187249985097606 908 701009 SGTC_3096 9117468 49.47 µM 0.887390253671796 0.23339371276516 no 773 0.187434414484388 819 41316311 SGTC_1819 st053448 58.6 µM 0.887173324754882 0.233449876308823 no 774 0.187492795847126 921 2857616 SGTC_1017 4239-0030 168 µM 0.886557227248194 0.233609426666064 no 775 0.187658665407006 897 1149593 SGTC_428 3448-4153 16.5 µM 0.884379626020571 0.234173842841141 no 776 0.188245658734419 839 3834874 SGTC_1827 berberine 7.24 µM 0.881653963017687 0.234881374822575 no 777 0.188981981858906 838 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_1146 3579-1023 7 µM 0.87851680534442 0.235697183629611 no 778 0.189831660919136 998 X1146 SGTC_1772 st048439 82.2 µM 0.878108032524481 0.235803598777121 no 779 0.189942547142604 904 2927068 YDL195W SEC31 SGTC_3171 9103192 49.47 µM 0.877674680114501 0.235916441608896 no 780 0.190060144448375 979 13018434 SGTC_372 0155-0182 15.9 µM 0.877400498620707 0.235987852488864 no 781 0.190134571213907 980 771486 SGTC_802 4112-3352 742 µM 0.877289773530616 0.236016694339953 no 782 0.190164632695959 988 704594 SGTC_2204 7233102 200 µM 0.876544850775618 0.236210783510361 no 783 0.190366952574841 881 2172480 SGTC_1806 st050005 60.3 µM 0.875357224771262 0.236520400452801 no 784 0.190689783257034 910 5194765 SGTC_2834 9001755 58.44 µM 0.875030763685391 0.236605548756289 no 785 0.190778583550777 862 2989575 SGTC_1537 2',6'-dihydroxyflavanone 78 µM 0.873261029908368 0.23706742803248 no 786 0.191260408232666 1007 5106787 A p450 inhibitor. SGTC_2404 5161160 200 µM 0.872803931381332 0.237186805724863 no 787 0.191384978203345 963 2831543 SGTC_3081 9117243 49.47 µM 0.86416753715451 0.239448516326703 no 788 0.193747931252028 963 45595589 SGTC_270 tamoxifen 5.46 µM 0.863832829441491 0.239536406462041 no 789 0.193839865254921 1017 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.  YIL048W NEO1 SGTC_826 1683-5028 118 µM 0.86322745635588 0.239695414725803 no 790 0.19400621030525 924 722377 SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.86319569387703 0.239703759099452 no 791 0.194014940433303 955 229346 A bile salt which induces apoptosis. SGTC_401 neomycin 50 µM 0.862808769940307 0.239805421256876 no 792 0.194121308261737 920 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis. SGTC_38 0929-0051 58.268 µM 0.861458078194029 0.240160492468089 no 793 0.19449290029648 1006 1379719 SGTC_1900 st060200 72.8 µM 0.856855619036044 0.241372540516376 no 794 0.195762341429188 950 688945 SGTC_1666 st014829 29 µM 0.856705290993615 0.24141218506169 no 795 0.195803889244834 990 3858230 SGTC_1073 triclabendazole 3.09 µM 0.856567462038295 0.241448536452987 no 796 0.195841987252479 995 50248 An antihelmetic and likely tubulin inhibitor. SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.856520226281044 0.241460995226779 no 797 0.195855044965078 1002 6708739 YPR165W RHO1 SGTC_2343 7990716 14.84 µM 0.856496748868763 0.241467187694561 no 798 0.195861535187824 967 6456862 SGTC_2259 7964009 200 µM 0.856473985242578 0.241473191974493 no 799 0.195867828212301 901 313134 SGTC_2295 7971645 200 µM 0.85590172355769 0.241624162024334 no 800 0.196026070768229 934 2978226 YKL099C UTP11 SGTC_680 0417-1641 114 µM 0.853651391345923 0.242218325479753 no 801 0.196649087305088 906 2835990 SGTC_2694 st077685 81.9 µM 0.853406562794667 0.242283016194449 no 802 0.196716941674583 936 2838096 SGTC_742 0kpi-0133 140 µM 0.852640910236414 0.24248538394308 no 803 0.19692923420843 992 2728852 SGTC_1468 k284-1086 134 µM 0.85263002739704 0.242488261019432 no 804 0.196932252693354 1016 15996457 SGTC_2532 xanthone 78.9 µM 0.852335285218662 0.242566188501626 no 805 0.197014013592907 876 7020 An insecticide. SGTC_2932 9016711 44.54 µM 0.85134134472346 0.242829078396793 no 806 0.197289882158027 1006 7117328 SGTC_62 0180-0423 3.232 µM 0.850928678049707 0.242938270953697 no 807 0.197404486563164 948 30102 YGL099W LSG1 SGTC_1116 jasmonic acid  1.58368 µM 0.849454237480123 0.243328628259095 no 808 0.197814292042402 971 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid. SGTC_1629 st005085 44.9 µM 0.849415733572029 0.243338826686634 no 809 0.197825000686924 951 24207091 SGTC_150 3970-0969 77.2 µM 0.84844961997173 0.243594794218204 no 810 0.198093809269412 983 6615640 SGTC_469 w7 172 µM 0.847775972756599 0.243773360079604 no 811 0.198281373313959 978 45115570 A P450 inhibitor. SGTC_3192 9110362 49.47 µM 0.847308825801319 0.243897229719792 no 812 0.198411504269341 1004 16649480 SGTC_2077 5212015 200 µM 0.846563412158777 0.244094955439133 no 813 0.198619257369178 927 780900 SGTC_2942 9052777 62.25 µM 0.846480423893034 0.244116973952331 no 814 0.198642395015666 1040 6469503 SGTC_917 harmaline 728.087 nM 0.846369098670758 0.244146512531636 no 815 0.198673435735211 962 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7 SGTC_2102 5377816 72.7585 µM 0.846193805484155 0.244193028015534 no 816 0.198722318517911 1019 1379702 SGTC_1133 3473-0247 50 µM 0.843404426206365 0.244933855237204 no 817 0.199501148655246 907 711311 SGTC_1942 st076330 65.2 µM 0.841019975535039 0.2455680955558 no 818 0.200168371941964 1028 24208414 SGTC_288 1315-0019 35.1 µM 0.839749382959371 0.245906420573553 no 819 0.200524459591861 996 6811474 SGTC_1221 2958-7315 257 µM 0.837732102387586 0.246444082189977 no 820 0.20109058976045 945 4562705 SGTC_3264 9137442 49.47 µM 0.834985715055103 0.247177082566932 no 821 0.201862875715842 962 17015726 SGTC_2997 9067075 71.4286 µM 0.832602223366876 0.247814171271245 no 822 0.202534552326484 988 27209819 SGTC_237 nikkomycin 200 µM 0.832376122092794 0.247874651865826 no 823 0.202598337793143 995 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. SGTC_692 k241-0027 77.8 µM 0.831234382821806 0.248180179871644 no 824 0.202920617400985 991 3600480 SGTC_1367 1812-0510 76.9 µM 0.8301541138789 0.248469443305038 no 825 0.203225827471384 983 1142582 YDR527W RBA50 SGTC_1635 st007035 42.4 µM 0.829771120265647 0.248572040563758 no 826 0.203334101011672 1049 3716403 SGTC_3147 9097027 49.47 µM 0.82967736662014 0.248597158956009 no 827 0.203360610715711 1026 25236841 SGTC_2362 9071156 126 µM 0.829456217096755 0.248656414493115 no 828 0.203423150942869 976 653133 SGTC_364 0083-0097 67.7 µM 0.828139559938216 0.249009359647218 no 829 0.203795733939226 978 5207356 SGTC_2863 9028737 58.44 µM 0.825177033239061 0.249804472786582 no 830 0.204635545201751 1003 6460917 SGTC_2197 6588183 93.1375 µM 0.824559492176693 0.249970384369072 no 831 0.204810863505504 983 884136 SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 0.82003591238609 0.251187492189608 no 832 0.206097817400779 978 1609 A potent and irreversible inhibitor of serine proteases. SGTC_954 1189-0853 2.85 µM 0.818748925383915 0.251534338853964 no 833 0.206464838223564 1064 2828194 SGTC_1564 D-Arginine 115 µM 0.818494518731639 0.251602932114379 no 834 0.206537435302356 1006 71070 D-isomer of arginine; arginine decarboxylase inhibitor. SGTC_2187 6125751 200 µM 0.817457537242562 0.251882625821276 no 835 0.206833503083483 996 874498 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.817204398766821 0.251950927014116 no 836 0.206905814584078 941 2374 Ca(2+)-ATPase inhibitor. SGTC_879 0831-1030 162 µM 0.816121138201099 0.252243320053676 no 837 0.207215427613675 1013 1549252 SGTC_3021 9087658 49.47 µM 0.816108247169986 0.252246800670026 no 838 0.207219113723589 1017 25237042 SGTC_532 1548-0774 215 µM 0.814918783678695 0.252568068259069 no 839 0.207559400232803 1045 5932993 SGTC_1130 3454-2858 15.9 µM 0.813474515750272 0.252958446716498 no 840 0.207973025823168 947 715628 YIL048W NEO1 SGTC_1770 st043884 66.3 µM 0.813443741790248 0.252966768218821 no 841 0.207981844505543 1062 670149 SGTC_1584 6-fluoro-dl-tryptophan 90 µM 0.81323382333742 0.253023535535806 no 842 0.208042005283679 1060 94937 An inhibitor of serotonin biosynthesis. SGTC_1253 0550-0034 176 µM 0.812914068109278 0.253110018404041 no 843 0.208133664051475 971 5969915 SGTC_1865 st057639 52.2 µM 0.812858185831353 0.253125134247607 no 844 0.208149685315432 1055 688818 SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.812170479964154 0.253311193707671 no 845 0.208346907891246 997 75037 A free radical scavenger. SGTC_1998 st075797 76.8 µM 0.810594437318538 0.253737864549553 no 846 0.208799306203593 1076 24208315 SGTC_1789 tunicamycin 25 nM 0.809595798181073 0.254008414217489 no 847 0.209086261916162 1036 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_837 0091-0265 12.5 µM 0.809494223248519 0.254035941208626 no 848 0.209115462148976 1019 759367 SGTC_2282 7944268 200 µM 0.807432265030795 0.254595073804317 no 849 0.209708742110601 1020 2970414 SGTC_370 0180-0345 38.7 µM 0.80631794745656 0.254897506737288 no 850 0.2100297723061 957 3989527 SGTC_1108 betulinic acid 729.144 nM 0.805959745123188 0.254994765065444 no 851 0.210133030186141 1037 64945 Apoptosis-inducing agent of unknown mechanism. SGTC_233 rapamycin 362 pM 0.804182107719849 0.255477712470073 no 852 0.210645905253618 1082 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C SGTC_1617 st002906 78 µM 0.803288075251664 0.255720783138318 no 853 0.210904124366378 1032 5150859 SGTC_3054 9094397 49.47 µM 0.803046399105743 0.255786511077924 no 854 0.210973958384062 1084 2598354 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 0.802965922077676 0.255808400132031 no 855 0.210997215794221 1038 6312947 SGTC_1761 st044296 37 µM 0.802181148530946 0.256021902980333 no 856 0.211224089730979 1082 1826700 SGTC_1729 st035615 45.989 µM 0.798656140584686 0.256982050066097 no 857 0.212244912530179 977 17385451 SGTC_949 1165-0505 146 µM 0.798605034936055 0.256995984064347 no 858 0.212259733619058 1059 6244267 SGTC_2173 5763948 167 µM 0.798140846997412 0.257122563292672 no 859 0.212394379913305 1087 2867177 SGTC_2411 st077133 39.94 µM 0.797409653292331 0.257322017955928 no 860 0.212606577360283 1072 1403142 YNL221C POP1 SGTC_1271 0832-2808 169 µM 0.792290401639276 0.258720693873498 no 861 0.214095683522022 1076 3663794 SGTC_962 1254-0300 21.5 µM 0.792147162501047 0.258759886019912 no 862 0.214137436538347 1026 7340576 SGTC_1669 st015249 58.4 µM 0.79138727010485 0.25896785413316 no 863 0.214359018075369 1149 722793 SGTC_2983 9022671 12.99 µM 0.790901870921384 0.259100743904912 no 864 0.214500628274794 1019 6405161 SGTC_566 0958-0068 16.5 µM 0.790486512342447 0.25921448635396 no 865 0.214621848023629 1013 6815365 SGTC_1144 3486-0183 12.5 µM 0.789691303227192 0.259432319654471 no 866 0.214854035778805 1058 6744069 SGTC_1909 st060837 51.5 µM 0.787997781747092 0.259896544460022 no 867 0.215349001703687 997 678937 SGTC_1466 k213-0079 57.5 µM 0.786060716492021 0.260428053882875 no 868 0.215915958576842 1054 3657981 SGTC_1442 4112-3290 3 µM 0.785353316702444 0.260622296073226 no 869 0.216123221817669 1093 704353 SGTC_1164 k060-0068 93.7 µM 0.783064015968643 0.261251417154407 no 870 0.216794760392474 1113 5963676 SGTC_423 5-fluorouracil 457 µM 0.782690730772364 0.261354073326159 no 871 0.216904373361983 1010 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_1888 azatryptophan 97.5 µM 0.781888636678749 0.261574725164508 no 872 0.217140011851489 966 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides SGTC_2894 9048625 32.47 µM 0.781054080105241 0.261804408721991 no 873 0.217385344060596 1093 4092861 SGTC_1041 0206-0046 107 µM 0.780650065667973 0.261915637225272 no 874 0.217504168499139 1037 50494 SGTC_2767 sibutramine 71.45 µM 0.779261187162358 0.262298191669962 no 875 0.217912936563625 1080 64765 A serotonin-norepinephrine reuptake inhibitor.  SGTC_3322 9139058 2.11 µM 0.778147472495321 0.262605161271423 no 876 0.218241039530909 1055 4908926 YPR165W RHO1 SGTC_1380 2291-0730 164 µM 0.77689626383209 0.262950247055105 no 877 0.218609987860847 1043 2999191 SGTC_2146 5545642 200 µM 0.776193627276259 0.263144137178374 no 878 0.218817334131389 1114 825326 SGTC_149 3970-0822 46.1 µM 0.775967804393458 0.263206467727483 no 879 0.218883997913913 1156 3114250 YBL034C STU1 SGTC_441 propafenone 146 µM 0.775588499110715 0.263311178722525 no 880 0.218995996581003 1076 4932 Slows the influx of sodium ions into the cardiac muscle. SGTC_3068 9116768 49.47 µM 0.772843751827505 0.264069526901914 no 881 0.219807428365065 1072 41904888 SGTC_3245 9134821 49.47 µM 0.771089476961596 0.264554798995341 no 882 0.220326948753903 1076 17014901 SGTC_1042 0350-0096 82 µM 0.769824246146681 0.264905071843562 no 883 0.220702077540836 1045 3122515 SGTC_2724 maprotiline 69.64 µM 0.768448326696667 0.265286255640561 no 884 0.221110439362239 1089 4011 A tricyclic antidepressant. SGTC_2434 5670830 169.91 µM 0.766227812215809 0.265902012217841 no 885 0.221770381210241 1047 1549830 SGTC_2440 5628896 157.78 µM 0.765973185516437 0.265972667364838 no 886 0.221846128678919 1072 5522048 SGTC_2280 7785178 200 µM 0.765801294691392 0.266020369906104 no 887 0.221897271870222 1056 2954328 SGTC_1336 1486-0901 104 µM 0.765337698313037 0.266149047155233 no 888 0.222035240651305 1081 5006114 SGTC_1689 st020265 53.493 µM 0.761488407673855 0.267218683985772 no 889 0.2231827001261 1082 5758320 YPR016C TIF6 SGTC_2028 5153890 36.43 µM 0.759758179087797 0.267700183878122 no 890 0.22369957267646 1099 2830968 YPR165W RHO1 SGTC_1156 4092-0367 4.88 µM 0.758861487907212 0.267949893160419 no 891 0.223967709467195 1103 1357585 SGTC_371 0195-0006 7.36 µM 0.75707878900493 0.268446684763937 no 892 0.22450133042883 992 3928593 SGTC_2702 st077768 96.8 µM 0.756403805117363 0.268634905936226 no 893 0.224703563648383 1028 6484119 SGTC_2505 galangin 7.89 µM 0.755822317618291 0.268797108533035 no 894 0.224877867047519 1012 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2892 9047358 58.44 µM 0.755145223414893 0.268986042038506 no 895 0.225080925525488 1068 6466771 SGTC_528 3492-0019 172 µM 0.755034019513005 0.269017078277424 no 896 0.225114285164901 1165 2869262 SGTC_2107 5363541 170.161 µM 0.754908694357816 0.269052057814502 no 897 0.225151884343074 1121 244052 SGTC_1773 st048542 73.5835 µM 0.753129783180028 0.269548816207524 no 898 0.225685964354539 1058 3237138 SGTC_2132 5317594 122.667 µM 0.7479680977044 0.270992806131325 no 899 0.227239700263502 1064 794577 SGTC_2438 5259590 200 µM 0.746839930787927 0.271308925800313 no 900 0.227580094498244 1137 1201127 SGTC_2461 5755302 26.15 µM 0.746475298590232 0.271411137387112 no 901 0.227690173888552 1108 2788904 SGTC_2966 9084041 48.03 µM 0.744561253444361 0.271947985915406 no 902 0.228268499359067 1082 17741380 SGTC_2341 7987486 176.74 µM 0.744163044812092 0.272059741215658 no 903 0.228388921092755 1148 1258686 SGTC_1730 st033808 45.1 µM 0.7438801746895 0.272139141198232 no 904 0.228474485145378 1141 1045166 SGTC_387 norethindrone acetate 66.7 µM 0.743368590950785 0.272282768999027 no 905 0.22862927743242 1075 541197 SGTC_2299 7976368 114.88 µM 0.742937321278331 0.272403877773619 no 906 0.2287598144557 1110 2979718 SGTC_168 3970-0862 530.542 µM 0.738956207230922 0.273523112634349 no 907 0.229966794980496 1170 3135186 SGTC_1956 st077085 54 µM 0.737754287652458 0.273861462372014 no 908 0.230331888088008 1158 24208685 SGTC_92 0063-0024 660.874 µM 0.736734800817818 0.274148617983194 no 909 0.230641819606322 1201 3594437 SGTC_1309 pyrazolanthrone 13.4 µM 0.736004429204917 0.27435443083603 no 910 0.230864001150677 1146 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14 SGTC_2628 lathosterol 100 µM 0.735820511648239 0.274406269345296 no 911 0.230919968332482 1188 6710616 SGTC_2053 5265679 138 µM 0.735345549950239 0.274540163134914 no 912 0.231064536975057 1137 764595 SGTC_2578 7,8-dihydroxyflavone 64.44 µM 0.735051002503799 0.274623213543923 no 913 0.23115421657439 1069 1880 Intensifies effect of antibiotics on Staphylococcus aureus. SGTC_693 4161-2696 114 µM 0.735043142732133 0.274625429849832 no 914 0.231156609871414 1114 805759 SGTC_577 r071-0003 38.6 µM 0.734884243988682 0.27467023816101 no 915 0.231204997434359 1194 4568517 YMR134W ERG29 SGTC_656 4090-1979 187 µM 0.734424728744166 0.274799838465501 no 916 0.231344959996439 1168 22330961 SGTC_424 splitomicin 100 mM 0.733683055492741 0.275009081342336 no 917 0.231570963992811 1083 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_1476 4112-3294 3.34 µM 0.73266659011317 0.275295976760465 no 918 0.231880902948363 1147 704369 SGTC_1676 st018489 23.4 µM 0.731726526396612 0.275561439005896 no 919 0.232167751162798 1103 3696235 SGTC_1824 st053723 68.6 µM 0.731559166142235 0.275608712647443 no 920 0.232218839668768 1133 675225 SGTC_1590 st077108 57.8 µM 0.731020797893458 0.275760810606582 no 921 0.232383224752274 1122 5489485 SGTC_321 4534-3890 65.3 µM 0.729525062155092 0.276183597148327 no 922 0.232840271484598 1165 699746 SGTC_2234 tolnaftate 200 µM 0.729278265871907 0.276253387460488 no 923 0.232915732132744 1123 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7 SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.728364703480565 0.276511804574753 no 924 0.233195181953679 1140 7104 SGTC_2081 5214970 32.255 µM 0.727806667468576 0.276669713116121 no 925 0.233365971243926 1108 2063512 SGTC_2795 7780010 54.55 µM 0.727010905278993 0.276894967909387 no 926 0.233609637641693 1105 953673 SGTC_997 3996-0078 137 µM 0.726745462966419 0.276970126097415 no 927 0.233690948783826 1192 735687 SGTC_3293 9120939 62.045 µM 0.726181002375293 0.277129982472857 no 928 0.233863908310189 1143 934087 SGTC_510 ag-490 170 µM 0.724802954421668 0.277520437971281 no 929 0.234286461517935 1247 5328779 SGTC_171 k064-0041 9.68 µM 0.723010884489357 0.278028604074431 no 930 0.234836598555603 1102 53325 SGTC_152 4469-0003 551.229 µM 0.721286118220418 0.278518113647056 no 931 0.235366748034533 1151 697280 SGTC_3212 9128307 49.47 µM 0.71971570984109 0.278964179429706 no 932 0.235850025819536 1088 27243542 SGTC_1912 st060209 90.8 µM 0.719054948808324 0.279151968747887 no 933 0.236053531940459 1139 688787 SGTC_2134 5324836 1.464 µM 0.716020363277378 0.280015191037075 no 934 0.236989387612249 1112 699272 SGTC_2607 solasodine 47.35 µM 0.715383654035459 0.280196474310484 no 935 0.237186005045644 1175 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity. SGTC_2922 7999257 32.47 µM 0.71524271645748 0.280236609613819 no 936 0.237229539038281 1142 2988377 SGTC_1708 st033234 31.827 µM 0.714793555335931 0.280364537426903 no 937 0.237368309007428 1213 674664 SGTC_1160 4092-0570 10.5 µM 0.712628308830249 0.280981628476087 no 938 0.238037894743684 1178 4994975 SGTC_1313 1220-0047 237 µM 0.710447399845313 0.281603846051513 no 939 0.238713369201429 1175 3528706 SGTC_2754 granisetron 64.02 µM 0.710278907487007 0.281651944887327 no 940 0.238765598518066 1170 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. SGTC_1390 3413-2614 145 µM 0.709996329381537 0.28173262021422 no 941 0.238853206204476 1208 3421432 SGTC_1266 0828-0227 32.9 µM 0.709972200926155 0.281739509342728 no 942 0.238860687563803 1132 3913820 SGTC_40 0327-0103 19.753 µM 0.708359036535544 0.282200282269183 no 943 0.239361161971761 1118 409036 SGTC_2536 dehydroabietamide 32.04 µM 0.707425285960174 0.282467157846184 no 944 0.239651113900228 1188 3983547 SGTC_3158 9100007 49.47 µM 0.707163751881299 0.282541928744406 no 945 0.239732360851109 1181 19297233 SGTC_1068 loratadine 26.9 µM 0.706544368385662 0.282719044415326 no 946 0.239924835557378 1166 3957 A H1 histamine antagonist. SGTC_1063 disulfiram 1.84 µM 0.70610941158235 0.282843454269493 no 947 0.240060049643911 1187 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase. SGTC_478 N-arachidonylglycine 10 µM 0.704261036798878 0.283372434427409 no 948 0.240635113064604 1115 5283389 SGTC_1197 1601-0112 267 µM 0.703595828525875 0.283562924147212 no 949 0.240842254955653 1190 7350313 SGTC_2929 9013348 24.6 µM 0.702059941676644 0.284002976498485 no 950 0.241320891315641 1173 2995952 SGTC_121 0557-0495 61.343 µM 0.701320950778563 0.284214823745519 no 951 0.241551370907149 1317 3104427 SGTC_1910 st062352 60.4 µM 0.699533637519577 0.284727506706956 no 952 0.242109299508937 1167 2245730 SGTC_1624 st003710 6.25 µM 0.699133684143854 0.284842291987257 no 953 0.242234244761071 1210 24207033 SGTC_2301 7769476 200 µM 0.698998537693499 0.284881083556231 no 954 0.242276472349453 1164 977820 SGTC_571 k831-0106 44.2 µM 0.697536679906507 0.285300846808896 no 955 0.24273349637283 1171 4783639 SGTC_1425 4048-4433 7.33 µM 0.697108165369414 0.285423947878053 no 956 0.242867552268563 1246 23734946 SGTC_2395 5646831 180.19 µM 0.696890160276859 0.285486584770325 no 957 0.242935768052367 1193 6808628 SGTC_1409 3909-8004 61.9 µM 0.695497222813665 0.285886955859197 no 958 0.243371875510338 1208 2119279 SGTC_72 0744-0168 198.391 µM 0.694371887162013 0.286210605164715 no 959 0.243724509636213 1129 677577 SGTC_3276 9139060 49.47 µM 0.693756606534273 0.28638763493835 no 960 0.243917429972481 1258 4870619 SGTC_506 n9-isopropylolomoucine 153 µM 0.693405170285425 0.286488774194463 no 961 0.244027659253091 1206 6610355 SGTC_3304 9125678 46.087 µM 0.69096922910117 0.287190275101536 no 962 0.244792439292614 1196 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2 SGTC_2148 5546263 113.568 µM 0.689072623853901 0.287737020720447 no 963 0.24538878336545 1184 792097 SGTC_482 fipronil 114 µM 0.687452477834025 0.288204458934369 no 964 0.245898818849404 1229 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels. SGTC_140 0062-0056 502.533 µM 0.687266145847313 0.288258241672472 no 965 0.245957514170315 1201 3758964 SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.686104229686457 0.288593723107851 no 966 0.246323691948275 1207 688667 SGTC_3045 9092950 49.47 µM 0.685215506511532 0.288850449291362 no 967 0.246603970102982 1238 44120432 SGTC_1913 st060213 96.1 µM 0.684758789501703 0.288982423305465 no 968 0.246748072153149 1233 688959 SGTC_2947 9072639 7.68 µM 0.683587401580534 0.289321039918345 no 969 0.247117871149977 1233 16488146 SGTC_1248 0469-0687 58.6 µM 0.683181183268335 0.289438510187616 no 970 0.247246180628593 1203 4017482 SGTC_2378 9074213 121.43 µM 0.682980712348774 0.289496490651974 no 971 0.24730951517087 1207 657714 SGTC_761 k216-0224 480 µM 0.681683663903381 0.289871756469268 no 972 0.247719499672205 1266 1340404 SGTC_3350 9150499 3.57 µM 0.681222540284509 0.290005225046589 no 973 0.247865343803515 1207 4910996 YPR165W RHO1 SGTC_2224 6650123 117.647 µM 0.680082742788205 0.29033525396017 no 974 0.248226035410631 1191 2908370 SGTC_2219 9098279 200 µM 0.679731096561279 0.290437108783503 no 975 0.248337371158039 1222 902349 SGTC_2202 7226349 200 µM 0.679578182971999 0.290481405637129 no 976 0.248385793883483 1180 844334 SGTC_3108 9121785 49.47 µM 0.679249918002963 0.290576509926546 no 977 0.24848976164369 1184 17140271 SGTC_1782 st039423 80.636 µM 0.6778557287201 0.290980593986791 no 978 0.248931586178029 1202 2068169 SGTC_2743 auranofin 4.32 µM 0.674039406236076 0.292088036492773 no 979 0.250143130492316 1181 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold. SGTC_1210 3013-0140 750 nM 0.673574782112699 0.292222997652577 no 980 0.25029084511743 1250 905973 SGTC_2270 7924575 90.91 µM 0.672450291306454 0.292549752845416 no 981 0.250648537766745 1218 1262135 SGTC_1418 3966-3099 2.4 µM 0.672416482861938 0.292559579551431 no 982 0.250659296187197 1234 740335 SGTC_170 4197-0004 226 µM 0.670857375687122 0.293012913574888 no 983 0.251155696131627 1232 218692 SGTC_2859 9028643 45.46 µM 0.669283602991113 0.293470842057462 no 984 0.251657292217726 1206 17151580 SGTC_2479 5617353 43.85 µM 0.669007856280013 0.293551111568744 no 985 0.251745233222754 1277 2731746 SGTC_133 0724-0033 378.92 µM 0.668923767110021 0.293575591840196 no 986 0.25177205412777 1137 280309 SGTC_2150 5556613 200 µM 0.668791965455141 0.293613964203871 no 987 0.251814096342316 1248 743190 SGTC_347 4534-1311 26.2 µM 0.667304161688066 0.294047280167317 no 988 0.252288934316012 1251 2862016 SGTC_651 3253-0966 34.4 µM 0.666458466214911 0.294293716756906 no 989 0.252559051381468 1259 781462 SGTC_1493 4348-0038 111 µM 0.665475173002708 0.294580369349792 no 990 0.252873308940271 1282 800424 SGTC_3191 9110352 49.47 µM 0.665404236336299 0.294601054001072 no 991 0.252895988043161 1235 17122424 SGTC_2902 5787006 60.46 µM 0.662947536316331 0.295317824145794 no 992 0.253682077654554 1219 591003 SGTC_878 0828-0289 13.7 µM 0.662922277206028 0.295325197944548 no 993 0.253690166669941 1253 745350 YLR208W SEC13 SGTC_411 enrofloxacin 100 µM 0.662232131377205 0.295526702439998 no 994 0.253911232405049 1306 71188 A bacterial gyrase inhibitor. SGTC_640 3381-0960 37.1 µM 0.662134308666815 0.295555269222789 no 995 0.253942574902441 1281 1745025 SGTC_3163 9099914 49.47 µM 0.661840276550143 0.295641141912226 no 996 0.254036795317525 1269 16268368 SGTC_1686 st019653 115.5 µM 0.661504997318274 0.295739074899031 no 997 0.254144255441344 1267 97252 SGTC_2153 5569715 200 µM 0.659828731073544 0.296228925294873 no 998 0.254681871776326 1262 2054701 SGTC_3036 9090181 49.47 µM 0.65978979736579 0.296240307199884 no 999 0.254694365766378 1269 25236586 SGTC_1374 2889-5571 141 µM 0.658714838147436 0.296554640655646 no 1000 0.255039451411781 1257 2853281 SGTC_1843 st055809 45.5 µM 0.658473925671167 0.296625107865771 no 1001 0.255116823173937 1247 16413835 SGTC_1496 4469-0713 57.4 µM 0.658384093782512 0.296651385772057 no 1002 0.25514567684138 1232 746691 SGTC_1155 4088-0394 48.2 µM 0.657612948215645 0.296877007542431 no 1003 0.255393436110164 1225 2326248 SGTC_1426 4048-4480 71.7 µM 0.656967871845983 0.297065804284936 no 1004 0.255600787487192 1250 14224343 SGTC_1149 3909-7961 23.3 µM 0.65642408727709 0.297224998242048 no 1005 0.255775648214018 1229 735261 SGTC_2931 9014674 55.67 µM 0.656105750086033 0.297318210144819 no 1006 0.255878042490047 1252 2996810 SGTC_2711 st079103 59.1 µM 0.652876546670658 0.29826450297663 no 1007 0.256917935021801 1253 54693780 SGTC_175 3793-3120 23.7 µM 0.652668271490235 0.298325583442109 no 1008 0.256985080779525 1261 5322297 SGTC_818 4072-2707 53.5 µM 0.651953652309968 0.298535201722171 no 1009 0.257215535970629 1214 882871 SGTC_2318 6029776 164 µM 0.651001663854181 0.298814551240511 no 1010 0.257522706414108 1305 818325 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 0.650961377952729 0.298826375271214 no 1011 0.257535709342127 1281 6708561 SGTC_3335 9143315 29.6265 µM 0.649883820864061 0.29914272031372 no 1012 0.257883634872283 1250 4899691 SGTC_812 4251-0442 148 µM 0.649654643979496 0.299210020774129 no 1013 0.25795766377283 1262 5723007 SGTC_1471 k673-0312 37 µM 0.648469558738525 0.299558144423129 no 1014 0.25834064677656 1269 24099884 SGTC_413 propylparaben 100 µM 0.64655333282544 0.300121431654007 no 1015 0.258960534705561 1243 7175 A pharmaceutical preservative. SGTC_458 nppb 133 µM 0.645250991600622 0.300504536645962 no 1016 0.259382273220821 1334 4549 A chloride channel blocker. SGTC_1474 0330-0125 5.35 µM 0.644828117384054 0.300628979503417 no 1017 0.259519289291541 1282 X1474 SGTC_2201 6605497 169.863 µM 0.644761634494436 0.300648546115061 no 1018 0.259540833905785 1267 670741 SGTC_2432 5630864 12.22 µM 0.642981063000418 0.301172800695776 no 1019 0.26011819384784 1260 5714970 SGTC_1953 st076800 12.1 µM 0.641126422686443 0.301719300874723 no 1020 0.26072027421317 1239 297591 SGTC_2553 4-methylesculetin 85.09 µM 0.640303403013182 0.301961959863537 no 1021 0.260987684398747 1279 5319502 SGTC_253 dyclonine 31.25 µM 0.639624450338547 0.302162208128285 no 1022 0.26120839138511 1350 3180 An oral anasthetic. SGTC_1948 st076329 66.6 µM 0.63894452901053 0.30236280179996 no 1023 0.261429509324909 1190 24208413 SGTC_2416 tofa 880 nM 0.638500827055679 0.302493737091478 no 1024 0.261573857923319 1216 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_2961 9083290 32.55 µM 0.638447648061469 0.30250943177998 no 1025 0.261591161275724 1275 17741490 SGTC_20 0481-0013 4.944 µM 0.637537758545604 0.302778023529788 no 1026 0.261887311631071 1261 182045 SGTC_2828 7998861 71.43 µM 0.63740735660805 0.30281652583606 no 1027 0.261929768866471 1221 2988188 SGTC_509 pifithrin 175 µM 0.636986899502227 0.302940684381751 no 1028 0.262066688459191 1345 4817 A p53 inhibitor. SGTC_2064 5220758 200 µM 0.635920775890416 0.303255606587481 no 1029 0.262414030238998 1324 788518 SGTC_2507 purpurin 79.67 µM 0.635893106818187 0.303263781701656 no 1030 0.262423047926359 1266 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1 SGTC_587 k089-0003 57 µM 0.635883723370206 0.303266554160991 no 1031 0.262426106142277 1240 9659696 SGTC_2519 cryptotanshinone 88.04 µM 0.635531174585215 0.303370727403028 no 1032 0.26254102065602 1266 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE) SGTC_636 0kpi-0074 126 µM 0.634163419509143 0.303775031193629 no 1033 0.262987088884589 1271 616434 SGTC_3272 9137413 49.47 µM 0.633481940516268 0.303976563780058 no 1034 0.263209485264796 1243 17614870 SGTC_940 3232-1287 54.8 µM 0.631553229590358 0.304547260892632 no 1035 0.263839428221781 1267 1585493 YIL048W NEO1 SGTC_1004 4084-0029 199 µM 0.631487991812158 0.30456657279752 no 1036 0.263860749190752 1312 716894 YLR208W SEC13 SGTC_2760 etidronate 98.04 µM 0.631124388541554 0.304674217829695 no 1037 0.263979597868448 1270 3305 A chelator and antioxidant. SGTC_2039 Aminomethylbenzodioxan 200 µM 0.628173873027444 0.305548345128438 no 1038 0.264945021902679 1281 15053 SGTC_1020 4335-0961 93.3 µM 0.626489756668885 0.306047783530825 no 1039 0.265496876764992 1249 669075 SGTC_41 0478-0632 82.643 µM 0.62623483740521 0.306123413371313 no 1040 0.265580460043611 1291 3750424 SGTC_212 3807-4682 38.772 µM 0.626090223367785 0.306166321361219 no 1041 0.265627882225505 1378 3125501 YBL034C STU1 SGTC_2403 6032726 181.2 µM 0.625777301107254 0.30625917667237 no 1042 0.26573051114072 1304 2881040 SGTC_1804 st050076 49.1 µM 0.625106637737232 0.306458228578133 no 1043 0.265950535871769 1320 3895976 SGTC_1684 st024538 14.6195 µM 0.623737415232378 0.306864789115691 no 1044 0.266400023499301 1296 6732859 SGTC_1462 k081-0014 26.5 µM 0.623484978844362 0.306939770516349 no 1045 0.266482935125086 1116 3270634 SGTC_2384 9036245 200 µM 0.623089241839983 0.307057332878084 no 1046 0.266612939475174 1346 6462766 SGTC_3095 9117207 49.47 µM 0.621779548540886 0.307446547433805 no 1047 0.267043417983835 1273 17015229 SGTC_16 erodoxin 22.806 µM 0.62130588720917 0.307587363506414 no 1048 0.26719919044532 1330 3967339 Erodoxin inhibits Ero1. YML130C ERO1 SGTC_1807 st050092 58.9 µM 0.620217419051908 0.307911064610373 no 1049 0.267557327428546 1284 5008496 SGTC_454 lyso-paf C-16 6.67 µM 0.619848468371968 0.308020821327452 no 1050 0.26767877759355 1239 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_1386 3228-0095 33.8 µM 0.616409119410665 0.309044795863255 no 1051 0.268812268034095 1347 870181 SGTC_1612 st002233 45.4 µM 0.613751067791056 0.309837178190722 no 1052 0.26968991829885 1325 1035021 SGTC_1379 2144-0755 36.5 µM 0.613150493256397 0.310016335939011 no 1053 0.269888417937987 1347 5392327 SGTC_1886 st057356 49.9 µM 0.61280859895668 0.310118346787798 no 1054 0.270001452216899 1258 24207747 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.612034606836061 0.310349336455505 no 1055 0.270257430608935 1359 5024745 SGTC_1290 0986-0249 10.2 µM 0.608692328987942 0.31134766181833 no 1056 0.271364196286855 1285 53329 SGTC_3057 9095946 49.47 µM 0.607067740111293 0.311833422338641 no 1057 0.271902979017779 1350 24540043 SGTC_2768 sulfasalazine 50.2 µM 0.604744976176382 0.31252850961503 no 1058 0.272674229479529 1418 5384001 An antioxidant and salicylic acid derivative. SGTC_18 0111-0177 500 nM 0.602425252809689 0.313223353242501 no 1059 0.273445552345183 1384 721752 SGTC_1122 capsaicin 818.572 nM 0.601169300656463 0.313599834841647 no 1060 0.273863614741751 1432 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_1668 st014914 51.6 µM 0.597930927123372 0.314571458300699 no 1061 0.274943011389109 1337 2839556 SGTC_1990 st072050 59.8 µM 0.595688543835483 0.315245004217719 no 1062 0.275691656421224 1333 17233948 SGTC_700 3453-2283 142 µM 0.594340754039534 0.315650136465148 no 1063 0.276142112934855 1416 565664 SGTC_1251 0490-5699 265 µM 0.592597036605069 0.316174609465924 no 1064 0.276725431400051 1383 3883818 SGTC_3030 9087619 49.47 µM 0.592582133055822 0.316179093732092 no 1065 0.27673041962262 1305 25236973 SGTC_418 lividomycin a 100 µM 0.592020588650023 0.316348074160581 no 1066 0.276918400804704 1345 72394 An antibiotic. SGTC_1457 k015-0032 57.3 µM 0.591709989627568 0.316441556363912 no 1067 0.277022402995823 1351 4302660 SGTC_2472 5377652 49.4 µM 0.591694297751859 0.316446279520461 no 1068 0.277027657832167 1331 1610903 SGTC_2788 5282734 71.43 µM 0.591266573855561 0.316575033268372 no 1069 0.277170911189783 1454 743706 SGTC_1057 3448-5381 134 µM 0.590238147685718 0.316884701796037 no 1070 0.277515500114636 1387 5497911 SGTC_1702 st027038 51 µM 0.590129121825274 0.316917538006927 no 1071 0.277552043062073 1372 5521182 SGTC_1105 epirubicin 18.1 µM 0.590025987709812 0.316948601080072 no 1072 0.277586613396897 1289 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2281 7943571 200 µM 0.588627156412157 0.317370043910556 no 1073 0.278055706324594 1412 1244024 SGTC_1682 st012968 530 nM 0.586685530106179 0.317955413692874 no 1074 0.27870746383618 1310 24207270 SGTC_2441 5730946 39.09 µM 0.586426318668206 0.318033596331853 no 1075 0.278794531157721 1408 1774275 SGTC_1494 4358-1428 177 µM 0.5855804336214 0.318288786247258 no 1076 0.279078750121605 1436 1564571 SGTC_34 0469-0683 81.75 µM 0.582889284849837 0.319101235858079 no 1077 0.279983917175606 1395 3690923 SGTC_2359 9039622 200 µM 0.579643808088685 0.320082192189056 no 1078 0.281077422071413 1333 6463596 SGTC_264 promethazine 12.5 mM 0.574540828686554 0.321627129545837 no 1079 0.282800940047323 1386 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3 SGTC_1519 esterone 74 µM 0.573730876280626 0.321872629092376 no 1080 0.283074965487036 1324 698 A steroid. SGTC_1613 st002381 52.1 µM 0.572272368826856 0.322314904123324 no 1081 0.283568733045685 1366 551167 SGTC_2751 anetholtrithion 17.25 µM 0.572064584596146 0.322377932712478 no 1082 0.283639110521886 1399 2194 A chloretic substance that stimulates the liver to produce bile. SGTC_2925 9010536 32.5 µM 0.571003389392846 0.32269991179947 no 1083 0.283998672652836 1448 2994177 SGTC_2031 5180455 200 µM 0.570816089266872 0.322756754670787 no 1084 0.284062157724262 1335 29949 SGTC_559 1550-0661 158 µM 0.56925689169745 0.323230109157853 no 1085 0.284590908494727 1426 5830875 SGTC_1281 0884-0031 11.8 µM 0.568558726148386 0.323442157067116 no 1086 0.284827820706127 1374 1548255 SGTC_3086 9117350 49.47 µM 0.568055019440113 0.323595179262518 no 1087 0.284998804585513 1314 2679265 SGTC_1193 1488-0126 41.5 µM 0.565929701350106 0.324241162684793 no 1088 0.28572078494117 1383 1384710 SGTC_2129 girgensonine 121.053 µM 0.565770831381202 0.324289471977587 no 1089 0.285774788733158 1468 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_487 nimodipine 119 µM 0.565150867594993 0.324478019292655 no 1090 0.285985576026533 1312 4497 L-type voltage-gated calcium channels inhibitor SGTC_36 0335-0881 14.2 µM 0.563818695256883 0.324883320180953 no 1091 0.286438763599381 1357 23828853 SGTC_2692 st077426 47.7 µM 0.563703785886233 0.324918289996444 no 1092 0.286477870222216 1391 25238571 SGTC_3011 9081274 71.4286 µM 0.562611197515256 0.325250869189873 no 1093 0.28684983273052 1377 6625322 SGTC_2805 7950783 58.44 µM 0.56045695595533 0.325907018776248 no 1094 0.28758389588833 1438 1178958 YDL195W SEC31 SGTC_2225 6654152 15.4 µM 0.560098427255802 0.326016273650424 no 1095 0.287706151573114 1384 97582 YGR029W | YLR033W ERV1 | RSC58 SGTC_3013 9080133 71.4286 µM 0.559900799051347 0.326076503513832 no 1096 0.287773551854484 1463 17050193 SGTC_1547 harmine 94.2 µM 0.559086161239068 0.326324823273139 no 1097 0.288051459426317 1409 5280953 A monoamine oxidase inhibitor YHR072W ERG7 SGTC_3157 9099274 49.47 µM 0.558561834243895 0.326484690564347 no 1098 0.288230396617134 1364 17217662 SGTC_1696 st025591 34.7925 µM 0.558253626126266 0.326578678091015 no 1099 0.288335603332115 1411 2787147 SGTC_791 1348-1292 225 µM 0.557921076319386 0.326680100920618 no 1100 0.288449139376914 1404 5437054 SGTC_935 2996-0153 430 µM 0.554863639043605 0.327613174071192 no 1101 0.28949396713134 1417 23738523 SGTC_1768 st044301 37.178 µM 0.554149626043056 0.327831233026197 no 1102 0.289738224832327 1373 3931349 SGTC_2447 5741742 33.78 µM 0.552177868712092 0.328433710792206 no 1103 0.29041324782866 1490 1776504 SGTC_2386 9075165 157.42 µM 0.550934097047915 0.328813979550312 no 1104 0.290839426266858 1380 16452277 SGTC_2127 5253358 187.912 µM 0.550830079381012 0.328845789784035 no 1105 0.290875081170526 1357 20612 SGTC_1173 0443-0020 122 µM 0.549691088695204 0.32919419207453 no 1106 0.291265635020499 1407 5331295 SGTC_1237 0330-0133 46.1 µM 0.549379421991138 0.32928955269675 no 1107 0.291372546513735 1384 X1237 YHR072W ERG7 SGTC_3210 9128157 49.47 µM 0.548948225583028 0.329421504118986 no 1108 0.291520490643112 1401 17590849 SGTC_2914 7968218 45.32 µM 0.547173323525327 0.329964869603954 no 1109 0.292129830756498 1469 2977111 SGTC_1372 2752-0194 270 µM 0.546654699206409 0.330123708182172 no 1110 0.292307991065336 1364 823334 SGTC_1750 st081859 2.357 µM 0.54654846145373 0.330156249297925 no 1111 0.292344492601812 1428 5291695 SGTC_1176 0848-0131 83.3 µM 0.544017336308554 0.330931924147184 no 1112 0.293214771526707 1472 6769040 SGTC_677 0929-0063 136 µM 0.543883367179059 0.330972999866226 no 1113 0.293260867696887 1390 1539583 SGTC_2476 5806916 10.51 µM 0.540203674716553 0.33210200909003 no 1114 0.294528289369476 1419 2870194 SGTC_750 4073-0104 132 µM 0.538341106438322 0.332674067638942 no 1115 0.295170788599073 1314 22330957 SGTC_786 4544-0069 423 µM 0.538195504498653 0.332718803429242 no 1116 0.295221041664038 1489 748821 YLR208W SEC13 SGTC_277 nystatin 15.5 µM 0.5372719146407 0.33300262929245 no 1117 0.295539901227766 1403 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_2531 methyl deoxycholate 70.07 µM 0.533274947476619 0.334232027738444 no 1118 0.296921633571443 1400 16667744 Haematoxylin. SGTC_1721 st082152 9.2685 µM 0.533093353828918 0.334287925205291 no 1119 0.296984479759546 1377 5296051 SGTC_3242 9133940 49.47 µM 0.527686670645312 0.335953868696979 no 1120 0.298858413121305 1465 17248444 SGTC_2677 mitomycin C 100 µM 0.527259609870059 0.336085595507227 no 1121 0.299006659237279 1442 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_2034 5197015 53.07 µM 0.527037473620483 0.336154121349233 no 1122 0.299083782858373 1531 780676 SGTC_1867 st057372 64 µM 0.526153020027183 0.336427016558642 no 1123 0.29939094636844 1429 688837 SGTC_2307 7538926 6.34 µM 0.525035916639776 0.336771818258769 no 1124 0.299779111563503 1439 96582 SGTC_1482 3346-2049 8.48 µM 0.523105378502028 0.337368015640437 no 1125 0.300450461424329 1476 3826804 SGTC_380 3970-0968 6 µM 0.521789721228589 0.337774556974241 no 1126 0.30090837356844 1401 2891601 SGTC_2388 9080168 200 µM 0.519526967434685 0.338474196118428 no 1127 0.301696656124224 1400 15943073 SGTC_2309 7664088 163.95 µM 0.518920599548627 0.338661778796767 no 1128 0.301908056037143 1476 704922 SGTC_74 000s-0487 160.283 µM 0.518704785960701 0.338728551378098 no 1129 0.301983311852152 1360 677548 SGTC_3268 9137683 49.47 µM 0.516667458938806 0.339359148545005 no 1130 0.302694157861956 1475 1953228 SGTC_724 3910-0327 137 µM 0.515610444821629 0.339686494946443 no 1131 0.303063256922766 1426 2885483 SGTC_560 2332-1943 155 µM 0.515281800986162 0.339788297223685 no 1132 0.303178057178103 1474 21177716 SGTC_1861 st057647 17.4 µM 0.514136779769564 0.340143075688764 no 1133 0.303578182196968 1565 688668 SGTC_1805 st050013 60.3 µM 0.511936810005481 0.340825121219347 no 1134 0.30434761747253 1496 4037144 SGTC_2306 7482397 179.52 µM 0.511713558110024 0.340894364013367 no 1135 0.304425747906914 1579 891448 SGTC_2813 7971799 71.43 µM 0.509509148076997 0.341578361263731 no 1136 0.305197693856064 1513 2234054 SGTC_1255 0566-0045 221 µM 0.508241737646461 0.341971856637865 no 1137 0.305641911830663 1531 2788469 SGTC_1864 st057645 30.4 µM 0.508060775544577 0.34202805431127 no 1138 0.305705361072397 1486 688666 SGTC_2992 9074591 71.4286 µM 0.507384598010655 0.342238071804685 no 1139 0.305942495208235 1465 17741321 SGTC_2030 5175110 200 µM 0.506110864318133 0.342633819885025 no 1140 0.306389412061518 1528 2831986 SGTC_3008 9078912 71.4286 µM 0.506034869474421 0.342657436890898 no 1141 0.306416085602121 1457 16648731 SGTC_157 1348-1695 65.819 µM 0.50502211027562 0.342972231925186 no 1142 0.306771653304204 1450 5380510 SGTC_2009 4012297 12.05 µM 0.503798037778237 0.343352854801807 no 1143 0.307201653364996 1462 45595307 SGTC_1238 0333-0287 48.8 µM 0.503054916735087 0.343584004351479 no 1144 0.307462831134175 1456 7226 SGTC_2123 5259487 200 µM 0.502995142465536 0.343602599821928 no 1145 0.307483843679794 1546 2173474 SGTC_1665 st014639 11.4 µM 0.502603045918492 0.34372458844063 no 1146 0.307621693674683 1551 981133 YIL048W NEO1 SGTC_214 4373-3496 70 µM 0.502144147028412 0.343867381194926 no 1147 0.307783063978512 1517 3779166 SGTC_1779 st039427 55 µM 0.501447553335926 0.344084178545807 no 1148 0.308028089951523 1630 1124498 SGTC_258 haloperidol 50.781 µM 0.500538490206251 0.34436717878041 no 1149 0.308347980524679 1421 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_3333 9141820 12.094 µM 0.500355470732604 0.344424165075737 no 1150 0.308412400930029 1466 1939433 SGTC_987 1497-1013 404 µM 0.498854337927446 0.344891702051006 no 1151 0.308941002076807 1482 1676435 SGTC_3066 9117245 49.47 µM 0.498264036995748 0.345075619826157 no 1152 0.309148976121082 1577 17176980 SGTC_979 1426-2828 121 µM 0.497291893577849 0.345378586545722 no 1153 0.30949161372102 1563 747872 SGTC_3317 9138495 8.753 µM 0.496987360966354 0.345473513970539 no 1154 0.309598982102522 1471 17020139 SGTC_2368 9071271 200 µM 0.496243750399849 0.345705349473196 no 1155 0.309861223491099 1449 27209959 SGTC_1081 sertraline 6 µM 0.494399205174815 0.346280673100916 no 1156 0.310512137610346 1558 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1 SGTC_956 1185-0240 191 µM 0.494339192114077 0.346299397467184 no 1157 0.310533325361351 1494 1416193 SGTC_1325 1431-0015 227 µM 0.493980938546757 0.346411182132905 no 1158 0.310659820692801 1401 1103340 SGTC_2442 5158906 48.48 µM 0.492503635998008 0.346872281158184 no 1159 0.311181676084762 1601 1893835 SGTC_2205 7238770 200 µM 0.491293424329052 0.347250184265889 no 1160 0.311609465004121 1525 279867 SGTC_460 trequinsin 123 µM 0.490544460529886 0.347484133322919 no 1161 0.311874338250277 1505 5537 A vasodilator. SGTC_1483 3453-0561 55.9 µM 0.490472087417377 0.34750674313181 no 1162 0.311899938372849 1528 4546991 SGTC_824 1304-0008 100 µM 0.490068627987527 0.347632796298675 no 1163 0.31204266839472 1505 768245 SGTC_452 diindolylmethane 8 µM 0.489713361214456 0.347743806543471 no 1164 0.31216837288664 1510 3071 Inhibits expression of several cancer promoting factors. SGTC_2087 5276107 200 µM 0.489189335443571 0.347907572757098 no 1165 0.312353829508651 1467 144405 SGTC_1526 st051518 75 µM 0.489188800986387 0.347907739797781 no 1166 0.312354018681306 1496 673993 SGTC_301 4119-0100 24.5 µM 0.48729763664609 0.348498994005637 no 1167 0.313023711149541 1514 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1 SGTC_2734 clemastine 41.6 µM 0.486788480950744 0.348658239580351 no 1168 0.313204117145218 1507 26987 Clemastine is a selective histamine H1 antagonist. SGTC_3069 9117009 49.47 µM 0.485086793084417 0.349190659679007 no 1169 0.313807389994721 1446 41904981 SGTC_578 3460-0051 92 µM 0.48400640776463 0.349528842285963 no 1170 0.314190660783494 1542 2876744 SGTC_2267 7931562 200 µM 0.483020762702855 0.349837473482205 no 1171 0.314540496986702 1407 934880 SGTC_2515 chrysin 20.77 µM 0.48252603464772 0.349992423172707 no 1172 0.314716154229088 1570 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor. SGTC_793 0488-0545 106 µM 0.48222222550587 0.350087589108969 no 1173 0.314824044936307 1471 292548 SGTC_1414 3917-0015 5.4 µM 0.480850418571043 0.350517414513112 no 1174 0.31531140678948 1509 6618702 SGTC_2026 5148700 152 µM 0.480613315419485 0.350591724970225 no 1175 0.315395675041429 1486 79838 SGTC_2802 7925815 54.55 µM 0.479871376352774 0.350824292889782 no 1176 0.315659427818316 1483 1262923 SGTC_1845 st056753 3.01 µM 0.479586766283803 0.350913521487661 no 1177 0.315760629111743 1440 5375839 SGTC_3326 9140064 16.379 µM 0.478429124032554 0.351276540617082 no 1178 0.316172404403278 1453 1868434 SGTC_315 k915-0449 187 µM 0.476586910738887 0.351854510641136 no 1179 0.316828152954249 1570 20970215 YNL149C PGA2 SGTC_937 3122-0005 46.7 µM 0.47593996732165 0.35205756190087 no 1180 0.317058573674926 1608 759535 SGTC_655 k060-0012 42 µM 0.47441836623566 0.352535301603417 no 1181 0.317600799289211 1473 5994525 SGTC_2192 5915882 198.485 µM 0.473925222397119 0.352690184787461 no 1182 0.317776616153048 1499 2876149 SGTC_2256 7954252 200 µM 0.472289967826209 0.353203948789871 no 1183 0.318359915056651 1489 2972920 SGTC_299 1273-0059 1.44 µM 0.468967858180757 0.354248512060608 no 1184 0.319546305359746 1530 2848077 SGTC_485 niflumic acid 177 µM 0.468517304381803 0.354390263343818 no 1185 0.319707349605713 1559 4488 A COX2 inhibitor. SGTC_1911 st060208 74.3 µM 0.465676151177263 0.355284598628832 no 1186 0.320723662791088 1620 688783 SGTC_1167 k781-0610 148 µM 0.465440689018027 0.355358753022611 no 1187 0.320807950778908 1538 4525169 SGTC_196 k015-0023 18.111 µM 0.464763183709333 0.355572151162208 no 1188 0.321050527717994 1525 5211998 SGTC_661 1304-0007 33.6 µM 0.462187847933748 0.356383733672778 no 1189 0.321973308477361 1512 3117130 SGTC_2194 5927483 104.545 µM 0.461531435576729 0.356590697454199 no 1190 0.32220868665161 1554 760979 SGTC_2544 sphondin 68.51 µM 0.460247348864316 0.356995686128699 no 1191 0.32266934419537 1600 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31 SGTC_527 4476-4215 268 µM 0.459519134450518 0.357225429655269 no 1192 0.32293070730907 1563 4418754 SGTC_1062 mesoridazine 14.2 µM 0.458216671425313 0.357636471271373 no 1193 0.323398391807764 1536 4078 A neuroleptic. SGTC_2570 licareol 100 µM 0.458062711043072 0.357685070235801 no 1194 0.323453693902583 1507 443158 SGTC_923 1900-2434 73.3 µM 0.456876203307416 0.358059679315494 no 1195 0.323880014595729 1495 5910570 SGTC_1019 4262-0212 3.4 µM 0.456046116461757 0.358321839030616 no 1196 0.324178408182925 1558 4677213 SGTC_825 1988-2224 89.6 µM 0.455135740706098 0.358609432553522 no 1197 0.324505793338938 1544 1180859 SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.454976970206287 0.358659597387069 no 1198 0.32456290355893 1692 1273210 SGTC_125 0133-0007 11.75 µM 0.454638034401416 0.358766695075612 no 1199 0.324684833576566 1719 26541 SGTC_1816 st051957 91.6 µM 0.453905267774709 0.358998274250142 no 1200 0.324948505957905 1554 674121 SGTC_1032 k061-1018 98.7 µM 0.451861182266885 0.359644548492536 no 1201 0.325684495202041 1710 4005393 SGTC_867 0518-0118 155 µM 0.449981880404996 0.360239077848187 no 1202 0.3263617529171 1572 6848158 SGTC_3154 9100113 49.47 µM 0.449793936917049 0.360298553614907 no 1203 0.326429515029329 1512 25237525 SGTC_2930 9013230 14.89 µM 0.448553735057653 0.36069110712694 no 1204 0.326876807323721 1656 2995857 SGTC_2541 muurolladie-3-one 83.07 µM 0.448307629901949 0.360769022760448 no 1205 0.32696559743933 1582 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils.  YMR203W TOM40 SGTC_178 4092-0806 87.505 µM 0.447851506845606 0.360913444267067 no 1206 0.327130183968249 1526 2169044 SGTC_1039 k821-0043 94 µM 0.44739716202583 0.361057322451633 no 1207 0.327294162269924 1660 15992768 SGTC_1034 k072-0165 12.7 µM 0.445921846537791 0.361524648715408 no 1208 0.327826850422803 1671 5835461 SGTC_3216 9129716 49.47 µM 0.445408721285185 0.361687236596922 no 1209 0.328012205376953 1482 8056934 SGTC_3286 9117135 37.221 µM 0.4441208258901 0.362095426600761 no 1210 0.328477615149033 1499 3438150 SGTC_2870 9038528 12.99 µM 0.443840435033442 0.362184315457693 no 1211 0.328578975967464 1529 6463316 SGTC_723 4182-0001 115 µM 0.442615133178401 0.36257284495135 no 1212 0.329022068438782 1534 744821 YLR208W SEC13 SGTC_2287 7945887 168.79 µM 0.440983857540649 0.363090323822887 no 1213 0.329612341690439 1641 1245853 SGTC_1014 4130-3005 69.3 µM 0.440787359139455 0.363152674614024 no 1214 0.329683472864933 1540 743608 SGTC_1934 st074720 32.6 µM 0.439306400224471 0.363622713377553 no 1215 0.33021976864504 1512 17250992 SGTC_1353 1498-1206 8.11 µM 0.43930562178979 0.36362296049753 no 1216 0.330220050629416 1552 6756808 SGTC_2807 7945238 51.95 µM 0.438315825514764 0.363937224682929 no 1217 0.330578677735659 1610 17148797 SGTC_190 3970-0790 3.722 µM 0.437653679257836 0.36414750982205 no 1218 0.330818676216578 1627 2832352 SGTC_652 0437-0092 114 µM 0.435963095143968 0.364684592817742 no 1219 0.331431752863925 1533 3091274 SGTC_2274 7947094 46.08 µM 0.433211815436648 0.365559216673851 no 1220 0.332430447950438 1536 2971028 SGTC_2593 nobiletin 86.24 µM 0.431212714778058 0.366195164047072 no 1221 0.333156854830022 1539 72344 An anti-infammatory. SGTC_1857 st056007 79.3 µM 0.430451705983148 0.366437350405388 no 1222 0.333433544946043 1590 619834 SGTC_1695 st026914 34.495 µM 0.43015566984036 0.366531576461105 no 1223 0.333541203252527 1553 3289191 SGTC_3308 9128332 17.569 µM 0.43010938952957 0.366546307859842 no 1224 0.333558035071607 1702 17332805 YDL196W YDL196W SGTC_907 3448-6986 75.5 µM 0.428916450536797 0.366926097821951 no 1225 0.33399201402018 1671 590582 SGTC_3023 9089636 49.47 µM 0.428493600385049 0.36706074978342 no 1226 0.334145895904991 1655 17249241 SGTC_269 exalamide 29 µM 0.427798830967395 0.367282026937681 no 1227 0.334398794064657 1625 3316 A derivative of salicylamide. SGTC_1862 st057513 3.81 µM 0.425665088447488 0.367961878031296 no 1228 0.335175952314525 1577 5393163 SGTC_777 1315-0167 517 µM 0.424485723018099 0.368337824080005 no 1229 0.335605807627296 1546 4221767 SGTC_637 1181-0519 7.26 µM 0.42386725154512 0.368535024514298 no 1230 0.335831314283356 1574 6252091 YGR060W ERG25 SGTC_3001 9076041 71.4286 µM 0.422873911318358 0.368851824795331 no 1231 0.336193629044135 1579 16004211 SGTC_102 gallobenzophenone 83.616 µM 0.422645166944695 0.368924789555232 no 1232 0.336277083726544 1683 70837 SGTC_847 0342-0274 5.54 µM 0.421551494486304 0.369273713869182 no 1233 0.336676208652458 1704 18097 SGTC_1191 1487-1166 10.6 µM 0.420871648625983 0.369490665617692 no 1234 0.336924404453112 1672 3955771 SGTC_625 k213-0058 121 µM 0.419512103920107 0.369924646805026 no 1235 0.337420955327624 1674 3655420 SGTC_2414 st077232 92.9 µM 0.418447603471897 0.370264562409603 no 1236 0.337809944019844 1518 729801 SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.41550618476604 0.371204340520268 no 1237 0.338885694266296 1660 5377381 SGTC_2985 9022375 71.43 µM 0.413428168468235 0.37186872668828 no 1238 0.339646470150045 1600 4939335 SGTC_784 4579-0127 173 µM 0.4133944401668 0.371879513499797 no 1239 0.339658823710329 1740 1948547 SGTC_1212 0520-0165 585 µM 0.412918189270472 0.372031836338947 no 1240 0.339833277030078 1801 5403258 SGTC_1642 st009582 77.7 µM 0.411951748926901 0.372341001626791 no 1241 0.340187394858069 1722 6739311 SGTC_1393 3470-5649 58.2 µM 0.410858789417205 0.372690739681829 no 1242 0.340588041048648 1573 4108395 SGTC_765 1319-0117 244 µM 0.410023939393454 0.372957955562447 no 1243 0.340894193284886 1544 3487746 YGL099W LSG1 SGTC_1199 1638-0010 4.46 µM 0.409426038802803 0.373149367073554 no 1244 0.341113516974818 1584 3111136 SGTC_1801 st050089 28.441 µM 0.409383460587123 0.373162999231056 no 1245 0.341129137692593 1610 5008493 YIL048W | YNL267W NEO1 | PIK1 SGTC_1099 5-nonyloxytryptamine 2.85 µM 0.407087818139738 0.37389822380538 no 1246 0.341971745092727 1570 23581825 A 5-HT1D beta serotonin receptor agonist. SGTC_3356 9151811 4.48 µM 0.405350925774956 0.374454802903696 no 1247 0.342609788980712 1593 1859254 YPR165W RHO1 SGTC_2033 5192550 145 µM 0.40414332411846 0.374841927559248 no 1248 0.343053663925985 1589 182073 SGTC_2945 9067681 61.76 µM 0.401180574855946 0.375792239085785 no 1249 0.344143590662456 1641 16456930 SGTC_950 1165-0508 94.1 µM 0.400651026157365 0.375962173146263 no 1250 0.344338536126744 1579 6148369 SGTC_2366 9070441 60.58 µM 0.400430735823306 0.376032872184917 no 1251 0.344419644916992 1561 6837235 SGTC_1733 st037357 54.9 µM 0.400313097198813 0.37607062832689 no 1252 0.344462961262217 1523 1272339 YGL099W LSG1 SGTC_1415 3966-0071 78.1 µM 0.399883652236833 0.376208468847209 no 1253 0.3446211067937 1645 2893185 SGTC_905 2-aminofluorene 215 µM 0.3978589349137 0.376858562245175 no 1254 0.345367085864828 1610 1539 An established DNA mutagen. YPR165W RHO1 SGTC_2059 5238311 157 µM 0.397459783073297 0.376986762632702 no 1255 0.345514218855347 1597 703021 SGTC_2052 5265182 7.135 µM 0.39646324495713 0.377306891912461 no 1256 0.345881658693335 1730 1239884 SGTC_1947 st076332 61.6 µM 0.392793548342487 0.378486475817306 no 1257 0.347235985080782 1691 24208416 SGTC_2179 6298986 200 µM 0.392444924210782 0.378598596347485 no 1258 0.347364749031077 1755 738374 SGTC_3090 9117696 49.47 µM 0.392302761757354 0.378644319953626 no 1259 0.347417261638999 1739 7923821 SGTC_138 0850-0259 40.9225 µM 0.391340686961533 0.378953795987373 no 1260 0.347772714094425 1630 6813004 SGTC_1930 st074634 34.3 µM 0.390218885693149 0.379314750140939 no 1261 0.348187348818383 1551 684253 YOR116C RPO31 SGTC_2567 aureobasidin a 60 nM 0.390151423061545 0.379336460477924 no 1262 0.348212289819439 1695 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1 SGTC_1274 0865-0114 173 µM 0.390067467700214 0.379363478917532 no 1263 0.348243329115658 1663 870624 SGTC_179 1273-0063 6.77 µM 0.387641562321781 0.38014443561244 no 1264 0.349140653498378 1587 3108139 SGTC_1117 retinoic acid 1.10837 µM 0.38663201503628 0.380469577169953 no 1265 0.349514326564847 1761 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR). SGTC_2732 terfenadine 20 µM 0.385960188070815 0.380685997080872 no 1266 0.349763076950712 1660 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.  SGTC_2321 7390090 138.78 µM 0.384176414985817 0.381260796324536 no 1267 0.350423848830168 1580 649046 SGTC_810 3825-7150 143 µM 0.384012637201921 0.381313584882347 no 1268 0.350484540575411 1816 22330411 YGL099W LSG1 SGTC_2269 7935389 174.42 µM 0.383217612883058 0.381569867037497 no 1269 0.350779209921269 1584 97605 SGTC_462 ag-879 158 µM 0.3826709576168 0.381746115669459 no 1270 0.350981875387665 1730 6809654 Ag-879 is a 5-Lipoxygenase inhibitor. SGTC_762 1165-0429 115 µM 0.381555590802338 0.382105800169696 no 1271 0.351395514860862 1766 5967793 SGTC_2895 9054447 58.44 µM 0.380054864800176 0.382589916194217 no 1272 0.351952344504694 1665 2697450 SGTC_3206 9114350 49.47 µM 0.379853295500176 0.382654954005589 no 1273 0.352027159037629 1630 17087243 SGTC_2792 7535235 81.82 µM 0.375568112046781 0.384038380127177 no 1274 0.35361900048169 1583 1281891 SGTC_194 1486-1323 56.904 µM 0.375174597777025 0.384165496448909 no 1275 0.353765310380252 1625 5178754 SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.375003853584839 0.384220655565172 no 1276 0.35382880035316 1633 688664 SGTC_77 0828-0286 12.516 µM 0.37477582268503 0.384294324877913 no 1277 0.353913598307131 1576 745345 SGTC_405 ebelactone b 50 µM 0.374692301267962 0.384321308957339 no 1278 0.353944659267864 1639 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).  SGTC_2266 7929956 200 µM 0.372917665344227 0.384894790217426 no 1279 0.354604861921345 1631 2967153 SGTC_1317 1273-0028 910 nM 0.372851646247688 0.384916129441051 no 1280 0.354629430885459 1654 5917803 YLR359W | YHR072W ADE13 | ERG7 SGTC_1273 0849-0096 14.1 µM 0.372129061621601 0.38514971183229 no 1281 0.354898379801623 1640 5286025 SGTC_3221 9128209 49.47 µM 0.371276266298152 0.385425439692382 no 1282 0.355215886709477 1677 16460723 SGTC_284 0988-0104 32.6 µM 0.371126411606051 0.385473897063374 no 1283 0.355271689973027 1735 4666532 SGTC_160 3453-0671 289.699 µM 0.370456174192539 0.385690648503365 no 1284 0.355521312617979 1599 5322268 SGTC_848 0368-0089 85.6 µM 0.367665434660285 0.386593542833968 no 1285 0.356561358546105 1747 762535 SGTC_1230 0170-0365 3.77 µM 0.367445307131789 0.386664787395668 no 1286 0.356643440652442 1743 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1 SGTC_345 1362-0200 395 µM 0.365173604172745 0.387400249735177 no 1287 0.357490910282107 1619 1419823 SGTC_641 4092-0595 30 µM 0.361629654758068 0.388548407513351 no 1288 0.35881440056353 1736 786260 SGTC_2115 tiliquinol 12.7705 µM 0.361404738075202 0.388621308313277 no 1289 0.35889845327828 1701 71208 A bioactive hydroxyquinoline. SGTC_2262 9014885 67.46 µM 0.359371116931187 0.389280630667787 no 1290 0.35965873943577 1810 6457424 SGTC_3114 9122766 49.47 µM 0.357743866475898 0.389808432948658 no 1291 0.360267500996692 1644 17176985 SGTC_756 0508-1999 28.3 µM 0.357437187329107 0.389907927800323 no 1292 0.36038227075818 1606 6753853 SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.357233439342371 0.389974033041571 no 1293 0.36045852713735 1711 165521 SGTC_1249 0481-0015 10.2 µM 0.356355442310202 0.390258932141591 no 1294 0.360787196909845 1651 4227577 SGTC_225 nsc-122657 1.016 µM 0.353669822501366 0.391130747622554 no 1295 0.361793170442824 1742 275685 SGTC_952 1185-0122 232 µM 0.353046119214911 0.391333294883559 no 1296 0.362026932857491 1660 678600 SGTC_6 0844-0013 19.835 µM 0.348664137760348 0.392757168620486 no 1297 0.36367073528845 1767 1584900 SGTC_2245 6637752 200 µM 0.346287344450142 0.393530081970356 no 1298 0.364563389311872 1835 681890 SGTC_1838 st055369 84.5 µM 0.345020919048998 0.393942084545057 no 1299 0.365039322072315 1674 676036 SGTC_1764 st044502 93.5 µM 0.344461806477788 0.394124016855876 no 1300 0.365249507259156 1692 8407 SGTC_889 0919-1524 82.7 µM 0.343819133788922 0.394333167733411 no 1301 0.365491154910049 1685 3905452 SGTC_2874 9043904 71.43 µM 0.343173625659176 0.394543272046785 no 1302 0.365733922453636 1698 4463428 SGTC_289 k017-0060 526 µM 0.342978888251587 0.394606662510569 no 1303 0.365807171324258 1700 5512909 SGTC_806 3966-4455 5.86 µM 0.34295451056466 0.39461459807457 no 1304 0.365816341134861 1653 714982 SGTC_1029 k015-0030 64.7 µM 0.342562530661899 0.394742203615863 no 1305 0.365963797209066 1752 2208316 SGTC_143 4032-1194 15.74 µM 0.341196732219456 0.3951869151936 no 1306 0.366477741580638 1702 1806963 SGTC_398 bronopol 33.3 µM 0.340847296022674 0.395300715525534 no 1307 0.366609271512514 1750 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them. SGTC_114 0364-0001 490.298 µM 0.336467075823557 0.396727969394703 no 1308 0.368259337717197 1666 4003655 SGTC_235 0330-0087 5 mM 0.331599091868288 0.398315780524186 no 1309 0.370096002700912 1726 46494818 YHR062C RPP1 SGTC_3141 9094609 49.47 µM 0.33137694961299 0.398388278013425 no 1310 0.370179886900996 1665 25236309 YDL196W YDL196W SGTC_1072 oxiconazole 14.9 nM 0.330703406856076 0.398608114257318 no 1311 0.370434264336 1758 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_145 3737-0113 38.366 µM 0.330473999165792 0.39868299751386 no 1312 0.370520917865413 1868 6849351 SGTC_46 0329-0187a 2.197 µM 0.329449569479514 0.399017437326687 no 1313 0.37090795295952 1784 46494817 SGTC_2302 7771753 200 µM 0.328252418576817 0.399408358402906 no 1314 0.371360408583794 1660 2203047 SGTC_447 ml7 120 µM 0.328163051283396 0.399437544705444 no 1315 0.371394191528401 1806 4216 Selective myosin light chain kinase inhibitor. SGTC_2000 st075254 36.4 µM 0.327079012120818 0.399791623804079 no 1316 0.371804062727607 1713 17234175 SGTC_228 caffeine 993.056 µM 0.326560745517933 0.399960934069647 no 1317 0.372000068797471 1812 2519 Caffeine is a phosphodiesterase inhibitor. SGTC_1301 naphtanilide LB 4.81 µM 0.326289449268879 0.400049570164465 no 1318 0.37210268503551 1843 67238 An a1-adrenergic receptor antagonist or alpha blocker. SGTC_1341 1486-1360 280 µM 0.325953768597194 0.400159248633959 no 1319 0.372229666882209 1708 3976547 SGTC_1351 1496-0003 46.5 µM 0.325629545953393 0.400265190846716 no 1320 0.372352327558403 1813 3891978 SGTC_3181 9108277 49.47 µM 0.320565103479926 0.40192098388652 no 1321 0.374269993184039 1711 17097298 SGTC_3291 9121177 71.43 µM 0.320524443451512 0.40193428463983 no 1322 0.37428540188732 1716 17015612 SGTC_1915 st067105 30.6 µM 0.320340004720725 0.401994619866616 no 1323 0.374355300121461 1702 69751 YOR207C | YOR116C RET1 | RPO31 SGTC_3077 9117319 49.47 µM 0.319039625214809 0.402420077702898 no 1324 0.374848232520549 1774 17154678 SGTC_1561 5-methoxyflavone 52.9 µM 0.316914283254108 0.40311569523447 no 1325 0.375654321890342 1856 94525 SGTC_1310 1188-0297 994 nM 0.316089374065797 0.403385768084439 no 1326 0.375967335929481 1800 1588352 SGTC_2830 7992007 71.43 µM 0.315208521239292 0.403674207593697 no 1327 0.376301668048692 1681 1952075 SGTC_229 benomyl 22.8748 µM 0.315027658806117 0.403733438359063 no 1328 0.376370326790632 1741 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C SGTC_422 cantharidin 155 µM 0.314523740691794 0.403898478497122 no 1329 0.376561644102828 1664 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2800 7887935 81.82 µM 0.314081095914964 0.404043464888173 no 1330 0.376729723428499 1790 2961002 SGTC_873 0591-4978 488 µM 0.311655323725011 0.404838249699129 no 1331 0.37765124221962 1925 3305145 SGTC_2060 5238662 140 µM 0.311258100679428 0.404968434153116 no 1332 0.377802208540235 1740 790130 SGTC_130 0136-0219 337.655 µM 0.310890232524129 0.4050890073219 no 1333 0.377942035057731 1900 234244 SGTC_2407 paclitaxel 400 µM 0.308956303970696 0.405723023366861 no 1334 0.378677383047602 1836 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_643 k048-0106 28.4 µM 0.307075163112675 0.406339970964609 no 1335 0.379393080981869 1839 6763920 SGTC_392 N-ethylmaleimide 8.33 µM 0.305776067843732 0.406766164095108 no 1336 0.379887575679525 1734 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides. SGTC_3031 9088762 49.47 µM 0.303809652035345 0.407411494504357 no 1337 0.380636456426817 1748 205253 SGTC_901 1112-0062 60.1 µM 0.303487803994752 0.407517141280501 no 1338 0.380759070241538 1772 1908457 SGTC_3164 9100705 49.47 µM 0.302986489430946 0.407681711426705 no 1339 0.380950078917259 1863 17174235 SGTC_644 1498-1197 63.3 µM 0.302935673282597 0.407698394120012 no 1340 0.380969442283508 1840 6741615 SGTC_327 1273-0057 3.96 µM 0.301073653605592 0.408309801277569 no 1341 0.381679165425115 1815 3108138 SGTC_11 0438-0307 1.3 µM 0.299987746644169 0.408666469583282 no 1342 0.382093251100249 1898 4011476 SGTC_1583 clindamycin 39.6 µM 0.297734360498079 0.409406839829256 no 1343 0.382952958094777 1702 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis. SGTC_606 k015-0008 38.6 µM 0.297485787164295 0.40948853067161 no 1344 0.383047828660279 1889 1970475 SGTC_2841 9004761 38.96 µM 0.294280184647296 0.410542366964978 no 1345 0.384271906493096 1645 2991039 SGTC_86 0417-1630 471.922 µM 0.294256841863653 0.410550043243836 no 1346 0.384280824320679 1871 3634867 SGTC_342 k048-0088 23.3 µM 0.293119779328213 0.410924007908308 no 1347 0.384715299360935 1748 6820570 SGTC_555 4296-0685 37 µM 0.291290899764658 0.411525671671597 no 1348 0.38541442338491 1822 2908540 YHR072W ERG7 SGTC_2977 9011197 71.43 µM 0.290844070259554 0.41167270107743 no 1349 0.385585289179306 1863 2704722 SGTC_1897 st060201 15 µM 0.289758228979667 0.412030049186765 no 1350 0.386000602980424 1746 611878 SGTC_1736 st036774 51 µM 0.289736504225317 0.412037199503712 no 1351 0.386008913624088 1982 1272247 SGTC_1002 4049-0206 172 µM 0.288675591236695 0.412386415656544 no 1352 0.386414821603091 1764 4662749 SGTC_3346 9158254 43.5805 µM 0.288031503191708 0.412598461202028 no 1353 0.386661311991245 1792 17639500 SGTC_3183 9108214 49.47 µM 0.287462965098264 0.412785655523518 no 1354 0.386878927663788 1886 4974831 SGTC_860 0443-0016 25.1 µM 0.286946922869037 0.412955582464638 no 1355 0.387076480627368 1872 5337942 SGTC_2984 9022109 38.96 µM 0.285060091491308 0.413577033576406 no 1356 0.387799052222678 1858 6459207 SGTC_709 3807-1509 243 µM 0.282188958947353 0.414523091351621 no 1357 0.388899311965587 1834 1886677 YPL242C IQG1 SGTC_1328 1441-0025 69.2 µM 0.282186740877574 0.414523822413223 no 1358 0.388900162307997 1710 4562601 SGTC_839 0122-0028 230 µM 0.280986334918556 0.414919511910151 no 1359 0.389360440466947 1836 759448 SGTC_836 0330-0104 1.35 µM 0.279344012250585 0.415461010073579 no 1360 0.389990416566099 1832 46494820 SGTC_2946 9065502 71.43 µM 0.278557703560667 0.415720324635998 no 1361 0.390292137974557 1836 16489101 SGTC_221 trifluoperazine 10.304 µM 0.277730318135541 0.415993225410297 no 1362 0.390609692657643 1821 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1 SGTC_2068 5226020 147 µM 0.276663954926482 0.416345009188135 no 1363 0.391019075828257 1775 1810509 SGTC_2722 naftopidil 47.16 µM 0.275812686530264 0.41662588321259 no 1364 0.391345969548017 1901 4418 An a1-adrenergic receptor antagonist or alpha blocker.  SGTC_3094 9117742 49.47 µM 0.274187829606961 0.417162119033844 no 1365 0.391970140216295 1764 17149698 SGTC_2133 5320837 200 µM 0.274033684245873 0.41721299815703 no 1366 0.392029367906515 1908 2841355 SGTC_2452 5863136 48.41 µM 0.27360634480815 0.417354058340673 no 1367 0.392193578776276 1803 2184096 SGTC_647 0140-0236 81 µM 0.271626961853405 0.418007569978382 no 1368 0.39295443303901 1859 990837 SGTC_795 0685-0265 78 µM 0.271028222779267 0.41820529392894 no 1369 0.393184662857888 1802 302754 SGTC_1674 st016616 23.6 µM 0.270968267262369 0.418225094413727 no 1370 0.393207719279937 1718 625830 SGTC_728 3030-5151 22.5 µM 0.269955950732459 0.418559446160108 no 1371 0.393597071011197 1851 3125388 SGTC_681 1642-0006 26.6 µM 0.268349455226192 0.419090166296301 no 1372 0.394215170951215 1866 4446530 SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.266820215122075 0.419595501247019 no 1373 0.394803794463639 1821 16486 A toxic proline analog. SGTC_1784 st039334 36.3 µM 0.265668340606812 0.419976223961784 no 1374 0.395247323963372 1949 3496984 SGTC_1337 1486-1011 40.3 µM 0.265266252427705 0.420109141599142 no 1375 0.395402180084238 1949 X1337 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.265124698150011 0.420155937136625 no 1376 0.395456700780497 1787 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1 SGTC_3033 9090887 49.47 µM 0.263826983461003 0.420584992989873 no 1377 0.39595662060336 1787 19325384 SGTC_550 4123-0385 25.7 µM 0.261816065024973 0.421250037481204 no 1378 0.396731626442097 1830 5731123 SGTC_317 4495-0002 170 µM 0.257938716794392 0.422532974490832 no 1379 0.398227101959024 1825 15991618 SGTC_2572 astragaloside iv 100 µM 0.256748010703623 0.422927120982927 no 1380 0.398686653164023 1845 45006101 An anti-inflammatory agent. SGTC_1217 1183-1422 255 µM 0.254975726281134 0.423513923814738 no 1381 0.399370923675602 1934 2849664 SGTC_2909 7941780 10.49 µM 0.253920371452051 0.423863432163891 no 1382 0.399778538160947 1999 1243215 SGTC_2558 carylophyllene oxide 100 µM 0.253343844762172 0.424054389370071 no 1383 0.400001258848842 1888 6708694 An oxygenated terpenoid and antifungal agent. SGTC_927 2425-1185 123 µM 0.253171135747018 0.42411159753399 no 1384 0.400067985201851 1794 730375 SGTC_2094 5332512 191.667 µM 0.251894857094845 0.424534401788383 no 1385 0.400561167444175 1940 755774 SGTC_2058 5236698 133 µM 0.250782515824938 0.424902967888937 no 1386 0.400991130021734 1843 766665 SGTC_1672 st016598 6.51 µM 0.250345450626984 0.42504780421358 no 1387 0.401160105344117 1830 4665860 YNL267W PIK1 SGTC_302 1094-0063 18.9 µM 0.249816781557959 0.425223010095881 no 1388 0.40136452066916 1848 5440289 SGTC_2370 9071495 200 µM 0.249704101585048 0.425260355205155 no 1389 0.401408093030268 1823 21791103 SGTC_64 000l-0018 272.079 µM 0.24940488598375 0.42535952638612 no 1390 0.401523803038118 1822 6811119 SGTC_290 2043-6722 48.1 µM 0.249256091047622 0.425408844321663 no 1391 0.401581346913681 1897 773758 YLR208W SEC13 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 0.248165907077858 0.425770220282456 no 1392 0.402003021789392 1848 689007 SGTC_51 1013-0126 23.419 µM 0.247779815135362 0.425898217637273 no 1393 0.402152386602731 2029 1627850 SGTC_137 0438-0332 85.389 µM 0.247087882108096 0.426127627077058 no 1394 0.402420105854358 1928 2063393 YER012W | YPR107C PRE1 | YTH1 SGTC_3288 9119690 36.221 µM 0.246008208476853 0.426485641292918 no 1395 0.402837939147614 1810 17595618 YKL019W RAM2 SGTC_1966 st070145 16.1 µM 0.245560647173197 0.426634068095454 no 1396 0.403011177773804 1847 3748532 SGTC_1809 st050081 57.6 µM 0.244147447567781 0.427102802048781 no 1397 0.403558313156734 1948 5036894 SGTC_984 1492-0255 2.91 µM 0.243883220339098 0.427190453109525 no 1398 0.40366063254413 1891 1585198 SGTC_2740 felodipine 17.08 µM 0.242242676219625 0.427734744646103 no 1399 0.404296064370199 2003 3333 L-type calcium channel blocker SGTC_918 glabranin 770.725 nM 0.242080757897611 0.427788472573297 no 1400 0.404358793902113 1896 124049 Also referred to as licorice root. SGTC_2166 5933061 31.504 µM 0.241832969423377 0.427870696627088 no 1401 0.404454795550132 1971 2877375 SGTC_2208 7283366 200 µM 0.241032975921125 0.428136181140152 no 1402 0.404764779371502 1981 898663 SGTC_2606 farnesol 9.78 µM 0.239591081616314 0.428614767866232 no 1403 0.40532363963559 1973 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2417 cerulenin 830 nM 0.239133210235641 0.428766764362605 no 1404 0.405501145324138 1899 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1 SGTC_595 3909-8003 73.7 µM 0.23874092505249 0.428896997052653 no 1405 0.405653240287226 1915 699517 SGTC_745 0469-0705 296 µM 0.238309723646757 0.429040158265324 no 1406 0.405820440098842 1998 3486736 SGTC_2550 chrysin dimethyl ether 71.87 µM 0.236984715217021 0.429480126608736 no 1407 0.406334324015971 1927 88881 An O-methylated flavonoid and antioxidant. SGTC_1981 st071826 47 µM 0.236901695975376 0.429507696025902 no 1408 0.406366527119576 1883 11838600 SGTC_1860 st056228 74.6 µM 0.233433498573744 0.430659736793388 no 1409 0.407712401733251 1860 688679 SGTC_3186 9110464 49.47 µM 0.233420520690233 0.430664048807792 no 1410 0.407717440009566 1974 17018021 SGTC_2070 5230947 200 µM 0.231692791049033 0.431238175580719 no 1411 0.408388315478533 2009 2835538 SGTC_2960 9079389 5.97 µM 0.23106259401269 0.431447627096884 no 1412 0.408633087232393 2005 16457355 SGTC_995 3931-2021 34.6 µM 0.229028286780078 0.432123878217469 no 1413 0.40942346535317 1907 730143 SGTC_2178 5812956 200 µM 0.228974266394395 0.432141838572258 no 1414 0.409444458628463 1960 5403383 SGTC_3261 9137475 49.47 µM 0.22862784646938 0.432257017400742 no 1415 0.409579089694823 1980 17027690 SGTC_1358 1509-0022 2.48 µM 0.228095116317989 0.432434152493597 no 1416 0.409786148323997 1935 3258434 SGTC_2001 4023502 57.655 µM 0.227454720212556 0.432647104956878 no 1417 0.410035087263508 1924 108941 YCR052W RSC6 SGTC_654 1124-0271 80.9 µM 0.225349759788511 0.43334721004654 no 1418 0.410853596146491 1832 5403748 SGTC_666 0272-0154 136 µM 0.225158326399325 0.433410890771436 no 1419 0.410928053884125 1921 6870312 SGTC_1802 st050112 57.9 µM 0.224089527308873 0.433766460792138 no 1420 0.411343820639625 2008 4662563 SGTC_2453 5731132 22.18 µM 0.223711458910512 0.433892250122628 no 1421 0.411490914497654 2021 1362040 SGTC_1448 4255-0083 152 µM 0.222578284682993 0.434269315152316 no 1422 0.411931869406917 2003 5399660 SGTC_2139 5578692 56.4705 µM 0.222334654540341 0.434350391186384 no 1423 0.412026688357552 2046 650991 YMR113W FOL3 SGTC_864 0469-0573 172 µM 0.221760904913003 0.434541336362822 no 1424 0.412250007517184 1850 689425 SGTC_1284 0929-0043 16 µM 0.221475236344069 0.434636413207259 no 1425 0.412361208193959 1901 1239883 SGTC_1287 0971-0001 34.6 µM 0.220875923116833 0.434835890238029 no 1426 0.412594522503472 1929 4665869 SGTC_1706 st031321 9.9705 µM 0.219909273247175 0.435157667521407 no 1427 0.412970907042901 2014 6103185 SGTC_541 4513-1321 94 µM 0.219748747408603 0.435211107339365 no 1428 0.413033418758358 1849 747515 SGTC_2304 7443016 91.4 µM 0.217899330548287 0.435826872151236 no 1429 0.413753774379864 1907 939854 SGTC_1187 1391-0724 117 µM 0.217710876437319 0.435889626857679 no 1430 0.413827194386462 1930 6997986 SGTC_2666 tannic acid 100 µM 0.216778718079161 0.436200056764446 no 1431 0.414190399052538 1958 16134267 A thiamine antagonist. SGTC_2092 5303694 80.6725 µM 0.216208555859406 0.43638995311967 no 1432 0.414412592330125 1887 1963699 SGTC_772 k072-0172 35.3 µM 0.214869591344697 0.436835961810872 no 1433 0.414934496867957 1807 5861980 SGTC_3349 9149703 23.001 µM 0.213925643752853 0.437150438774053 no 1434 0.415302521146266 2001 4910494 SGTC_475 α-linolenic acid 10 µM 0.212562545697978 0.437604626111769 no 1435 0.415834093989472 2029 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2779 methotrexate 400 µM 0.211526857421108 0.437949774780297 no 1436 0.416238088557693 2038 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2 SGTC_2290 7904846 200 µM 0.210969495195171 0.438135538285815 no 1437 0.416455537462578 1889 2962154 SGTC_776 4476-4378 112 µM 0.210857596983534 0.438172834535349 no 1438 0.416499196435995 1888 2892008 SGTC_499 genistein 192 µM 0.210809832760595 0.438188754763806 no 1439 0.416517832766419 2033 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger. SGTC_58 0957-0393 9 µM 0.210368543185939 0.438335845122453 no 1440 0.416690021101269 1909 6997992 SGTC_819 1013-0258 27.7 µM 0.210268173651946 0.43836930142114 no 1441 0.416729186876139 1916 5753198 SGTC_3097 9117246 49.47 µM 0.210217606363731 0.438386157243613 no 1442 0.416748919342533 1996 16423892 SGTC_2750 bromebric acid 70.15 µM 0.210059426678832 0.438438884713606 no 1443 0.416810645883551 1930 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2 SGTC_2761 levamisole 97.89 µM 0.208757937949165 0.438872763163693 no 1444 0.417318604238667 2043 26879 An alkaline phosphatase inhibitor. SGTC_2079 5212404 121 µM 0.207685182764382 0.439230443763657 no 1445 0.417737393932067 2071 758462 SGTC_166 k072-0058 166.424 µM 0.206287438088336 0.43969655754396 no 1446 0.418283195233915 2085 5846229 SGTC_1259 0671-0132 43 µM 0.205498312781922 0.439959748565877 no 1447 0.418591408087962 1903 X1259 SGTC_2991 9074669 71.4286 µM 0.203424188615509 0.440651641813661 no 1448 0.419401747630869 2008 17333109 SGTC_2401 5128683 200 µM 0.202285975876779 0.441031407758747 no 1449 0.419846581489447 1891 708373 SGTC_646 4092-0839 27.3 µM 0.202238837724522 0.441047136627519 no 1450 0.419865006133624 2014 877796 SGTC_2239 6685329 187.64 µM 0.202089617156534 0.441096928558595 no 1451 0.419923332358111 1902 805680 SGTC_2835 9006588 71.43 µM 0.20107121051296 0.441436775390867 no 1452 0.420321446464824 1894 2345538 SGTC_3337 9144342 33.5465 µM 0.200891646854078 0.441496701062502 no 1453 0.420391649706578 2005 17682949 SGTC_2198 6589944 200 µM 0.200381935024806 0.441666814176028 no 1454 0.420590943367669 1995 5290268 SGTC_410 α-linolenic acid 100 µM 0.200184091186388 0.441732846211951 no 1455 0.420668304373052 2016 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation. SGTC_2147 5545932 89.7195 µM 0.198736969553146 0.442215884286826 no 1456 0.421234251644247 1962 797404 SGTC_1401 3807-4679 7.6 µM 0.198657375465589 0.442242454680874 no 1457 0.421265384415316 1954 3291456 SGTC_2851 9015922 71.43 µM 0.196778450050236 0.442869759751143 no 1458 0.422000457878231 2010 2996893 SGTC_798 1287-0182 476 µM 0.195303299683848 0.443362359428647 no 1459 0.422577757019282 2081 1649755 SGTC_1067 clotrimazole 1.36 µM 0.193295516167393 0.444032962793286 no 1460 0.423363768846509 1952 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_2061 5245884 80.95 µM 0.193250518865132 0.444047993817883 no 1461 0.423381388003496 1957 573863 SGTC_2861 9024595 19.48 µM 0.191200139123695 0.444732993448945 no 1462 0.424184397310563 2096 16482810 SGTC_754 3474-0146 171 µM 0.187628147992325 0.445926732649352 no 1463 0.425584079601106 1860 24762078 SGTC_3336 9143619 71.43 µM 0.186973883516738 0.446145437579653 no 1464 0.425840554879892 2072 45595730 SGTC_298 1391-0729 10 µM 0.186883021894013 0.446175811739291 no 1465 0.425876175620268 1951 3237558 SGTC_1058 3448-5425 97.3 µM 0.184947917906547 0.446822772952269 no 1466 0.42663494309989 2075 7279705 SGTC_3047 9092122 49.47 µM 0.179509675888396 0.448641686900779 no 1467 0.428768760235812 1957 17173831 SGTC_1357 1503-1303 39.5 µM 0.179430720299717 0.448668103007542 no 1468 0.428799755741504 2003 292895 SGTC_1646 st011709 75.6 µM 0.17939463537904 0.448680175985735 no 1469 0.42881392170401 2098 5757843 SGTC_449 xestospongin c 11.1929 µM 0.178244515899403 0.449064997771744 no 1470 0.429265475404806 2045 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1 SGTC_1847 st056231 15 µM 0.178104287754297 0.449111920394949 no 1471 0.42932053736562 2069 5393180 SGTC_1158 4092-0494 91.8 µM 0.17723240327841 0.449403683097246 no 1472 0.429662922199247 2064 1148199 SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.176037123328601 0.449803709540081 no 1473 0.430132388816742 2033 5357218 A potent inhibitor of glutathione S-transferases. SGTC_3173 9105693 49.47 µM 0.17590019599486 0.449849538515991 no 1474 0.430186175685159 2044 17096658 SGTC_783 0848-0141 92.7 µM 0.17544324754735 0.450002481987201 no 1475 0.430365680451257 2022 6755076 YHR007C | YLR033W ERG11 | RSC58 SGTC_3018 9082602 49.47 µM 0.174229123196572 0.450408892936146 no 1476 0.430842699277628 2003 17332089 SGTC_2644 guaiazulene 100 µM 0.174059453672606 0.450465691560194 no 1477 0.430909369000335 2093 3515 A coloring agent. SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.173992238565125 0.450488192791669 no 1478 0.430935780962109 2082 91467 include heat shock SGTC_203 k066-0004 30.888 µM 0.173784436153149 0.450557758667287 no 1479 0.431017438209235 2129 6795412 SGTC_2974 9094440 9.66 µM 0.17276649910358 0.450898554683502 no 1480 0.431417485428746 2045 25236134 SGTC_998 3996-0085 177 µM 0.172512862944654 0.450983475393702 no 1481 0.431517174896237 2073 715391 SGTC_699 0375-0592 111 µM 0.17250150830767 0.450987277127477 no 1482 0.431521637838763 2163 762578 SGTC_739 1486-1183 203 µM 0.17186708000619 0.451199702104865 no 1483 0.431771013893132 2120 4346692 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 0.171699113199592 0.451255944600866 no 1484 0.431837041512491 1997 5379071 SGTC_2684 capsaicin 100 µM 0.171556837630901 0.451303585333274 no 1485 0.431892971416167 2030 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. SGTC_2720 fluspirilene 36.88 µM 0.171372878002927 0.45136518494177 no 1486 0.431965289750726 2071 3396 An atypical antipsychotic. SGTC_363 0455-0021 3.06 µM 0.170486919497085 0.451661868025141 no 1487 0.432313610251885 2020 4597466 SGTC_2673 kobusone 100 µM 0.17002963639463 0.451815010106599 no 1488 0.432493414760426 2051 6710676 An epoxy ketone and protein crosslinker. SGTC_1252 0493-0875 34.8 µM 0.169307187136617 0.452056969760631 no 1489 0.432777511538249 1994 3960963 SGTC_1307 1187-1599 12.2 µM 0.169253567105413 0.452074928666014 no 1490 0.432798598528159 1977 1538471 SGTC_1870 st057514 26.5 µM 0.168944830852757 0.452178335308332 no 1491 0.432920018035782 1996 5393161 SGTC_2140 5586273 200 µM 0.16867027574213 0.45227029620804 no 1492 0.433028000136233 2115 854421 SGTC_2357 9067248 200 µM 0.167158852897478 0.452776585659842 no 1493 0.433622529728252 2022 9150235 SGTC_448 monastrol 171 µM 0.165545579265779 0.453317077318953 no 1494 0.434257288815451 2090 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity SGTC_1090 efavirenz 20.7 µM 0.164502569090421 0.453666560912959 no 1495 0.434667762229085 2045 64139 A non-nucleoside reverse transcriptase inhibitor. SGTC_2970 9090938 41.86 µM 0.163534917923603 0.453990825900841 no 1496 0.435048641332991 2149 17217104 SGTC_2339 9000433 200 µM 0.162367032466144 0.454382231279567 no 1497 0.4355084153 1940 2988954 SGTC_2335 9018011 154.17 µM 0.161705828639146 0.45460384693461 no 1498 0.435768757182654 2102 6458208 SGTC_3058 9093861 49.47 µM 0.159246258991116 0.455428344285931 no 1499 0.436737429718723 2077 17217477 SGTC_668 1682-0499 62.6 µM 0.158164807171366 0.455790929731503 no 1500 0.437163467227476 2001 682214 SGTC_1977 st070720 65.3 µM 0.156205677940881 0.456447873411419 no 1501 0.437935450663549 1986 682188 SGTC_1510 1123-0200 71.5 µM 0.155395145063529 0.456719699720433 no 1502 0.438254905676897 2102 5378812 YNL149C | YNL150W PGA2 | YNL150W SGTC_1960 st011366 51.8 µM 0.154749339316825 0.456936296422664 no 1503 0.438509465662123 2119 3972846 SGTC_1395 3486-0190 4.35 µM 0.154707809360153 0.456950225587736 no 1504 0.43852583657271 2133 6748079 SGTC_385 1494-0393 12.4 µM 0.153759065262818 0.457268449132307 no 1505 0.438899855558684 2058 3090647 SGTC_3338 9144300 39.5675 µM 0.153171688228755 0.457465478282771 no 1506 0.439131441852196 2070 4901274 SGTC_1433 4060-0023 7.6 µM 0.151911562394473 0.457888208812659 no 1507 0.43962834433336 2101 3840627 SGTC_1871 st057448 67.3 µM 0.151768016887513 0.45793636661306 no 1508 0.439684954348285 2106 691747 SGTC_801 0866-0028 10.1 µM 0.15110236177604 0.4581596940003 no 1509 0.439947484732898 1986 6849771 SGTC_3318 9139014 38.6185 µM 0.150679909990698 0.458301433492211 no 1510 0.440114110888669 2001 16643984 SGTC_2310 7668677 200 µM 0.150431549512547 0.45838476497583 no 1511 0.440212075781898 2074 2197143 SGTC_3167 9103034 49.47 µM 0.149391441904348 0.458733768307745 no 1512 0.440622382162612 2128 5127859 SGTC_3123 9126162 49.47 µM 0.149128866901826 0.458821879183725 no 1513 0.440725974040942 2058 25239884 SGTC_2618 avocadyne 43.43 µM 0.149003653048938 0.458863897232982 no 1514 0.440775375214979 2060 3015189 SGTC_1854 st056233 32.9 µM 0.148636756673046 0.458987019401784 no 1515 0.44092013376588 2168 5393174 SGTC_2486 5283202 22.39 µM 0.148332881654962 0.459088995999946 no 1516 0.441040033288964 1986 1377751 SGTC_3331 9141060 1.957 µM 0.146720733024042 0.45963005748021 no 1517 0.441676226560373 1996 4906567 YPR165W RHO1 SGTC_3144 9087057 49.47 µM 0.146643041512059 0.459656133824083 no 1518 0.441706889344905 2199 17249618 SGTC_2915 7971052 15.16 µM 0.146635931263548 0.459658520313341 no 1519 0.44170969558935 2152 5741558 SGTC_1079 idarubicin 2.36 µM 0.14589338172264 0.459907758196201 no 1520 0.442002778153918 2176 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2701 st077767 14.721 µM 0.144928912377482 0.460231507306489 no 1521 0.442383499326498 2032 5721188 SGTC_1833 st055984 71 µM 0.143767009329522 0.460621565147753 no 1522 0.442842227464777 2023 676288 SGTC_1588 farnesol 29.9 µM 0.143441880292107 0.460730719722462 no 1523 0.442970604623765 2007 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures. SGTC_2965 9082772 38.63 µM 0.143426670133228 0.460735826254975 no 1524 0.442976610499763 2164 16459634 SGTC_3046 9092212 49.47 µM 0.142777971755396 0.460953620880907 no 1525 0.44323276740609 2134 25236637 SGTC_500 h-89 112 µM 0.139872652155916 0.461929198493106 no 1526 0.444380304629929 2170 449241 Protein kinase A inhibitor; also known to inhibit several other kinases. SGTC_639 0833-0042 114 µM 0.133496393034128 0.464071078326535 no 1527 0.446900408341094 2031 5978911 YPR085C | YHR062C ASA1 | RPP1 SGTC_2215 7188065 200 µM 0.133352244084746 0.464119512367478 no 1528 0.446957405850785 2165 940217 SGTC_1527 coumarin 137 µM 0.132833841260633 0.464293700084188 no 1529 0.447162395025108 2108 323 A hepatotoxic, DNA x-linker. SGTC_2647 atorvastatin 60.16 µM 0.132552552613356 0.46438821830605 no 1530 0.447273629357413 2130 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7 SGTC_2575 plumbagin 510 nM 0.130153247995102 0.465194510459848 no 1531 0.448222591276907 2027 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_751 0833-0568 350 µM 0.129123634420904 0.465540558624198 no 1532 0.448629910496276 2094 6954252 SGTC_115 0527-0192 112.043 µM 0.128375493405678 0.465792021578671 no 1533 0.448925912049589 2041 4233931 SGTC_1184 1269-1718 139 µM 0.127964787392622 0.46593007268776 no 1534 0.449088419740493 2159 5403821 SGTC_3088 9117578 49.47 µM 0.127718629542953 0.466012815989634 no 1535 0.449185823295456 2172 678341 SGTC_2623 humulene 100 µM 0.127173178155006 0.466196168810541 no 1536 0.449401666861068 2070 6187145 An anti-inflammatory. SGTC_2886 9058944 51.95 µM 0.126433490643 0.466444825323514 no 1537 0.449694396578593 2188 4949929 SGTC_2214 7179297 48.276 µM 0.125679039236573 0.466698458422686 no 1538 0.449992997276875 2124 769744 SGTC_565 1418-0001 44.5 µM 0.125455608253885 0.466773574532019 no 1539 0.45008143339413 2174 2862145 SGTC_993 3909-8757 62.7 µM 0.122950384937833 0.467615895464395 no 1540 0.451073193426146 2090 4288324 YLR208W SEC13 SGTC_2638 epoxomicin 18 µM 0.120972796644946 0.468280914456815 no 1541 0.451856291027578 2184 9915668 A protesome inhibitor. SGTC_2450 5739737 12.93 µM 0.120334186013986 0.46849568401732 no 1542 0.452109212168707 2096 2262825 SGTC_429 1112-0049 25.5 µM 0.118239341675822 0.469200259969132 no 1543 0.452939009215155 1999 2836170 SGTC_365 0121-0052 13.6 µM 0.117678980675254 0.469388747164204 no 1544 0.453161011015599 2146 3101739 SGTC_226 1,3-diallylurea 8.28947 mM 0.116778964499705 0.469691497641203 no 1545 0.453517606789225 2145 74537 YKL182W FAS1 SGTC_2873 9040596 71.43 µM 0.115971489380741 0.469963133763705 no 1546 0.453837568740182 2033 6463863 SGTC_3231 9132313 49.47 µM 0.114653624693146 0.470406495848744 no 1547 0.454359836782608 2115 4905967 SGTC_2944 9067346 25.62 µM 0.114518461939024 0.470451970006286 no 1548 0.454413406081589 2132 6473075 SGTC_2869 9037858 32.47 µM 0.11263737417228 0.471084882916355 no 1549 0.455159026641036 2235 27187042 SGTC_2342 7990637 118.86 µM 0.112437397515166 0.471152171610899 no 1550 0.455238302192668 2121 2033102 YER133W GLC7 SGTC_136 0097-0015 404.482 µM 0.111337229797454 0.471522373741841 no 1551 0.455674466903578 2213 4861337 SGTC_2686 alizarin 95.37 µM 0.111249397217352 0.471551930126183 no 1552 0.455709290696899 2101 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1 SGTC_2474 5321570 43.32 µM 0.111207397998064 0.471566063263685 no 1553 0.455725942635102 2186 2841384 SGTC_2451 5856223 45.7 µM 0.111045660687108 0.471620489744314 no 1554 0.455790069308226 2111 2179896 SGTC_2662 daunorubicin 22.37 µM 0.110827704564947 0.471693835344993 no 1555 0.455876487807003 2179 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_49 0717-0965 32.132 µM 0.109764052708288 0.472051784347179 no 1556 0.456298250258239 2155 5889349 YGL099W LSG1 SGTC_989 1501-0895 10.3 µM 0.105073756084855 0.473630467469363 no 1557 0.458158641808816 2245 2830112 SGTC_893 0958-0369 48.9 µM 0.103010319570761 0.474325121756825 no 1558 0.458977390346639 2242 6819948 SGTC_2421 5690543 90.72 µM 0.101109217880825 0.474965195298993 no 1559 0.459731880368662 2135 3397993 SGTC_883 0850-0245 24.6 µM 0.100941589731306 0.475021636405397 no 1560 0.459798413931857 2172 6823229 YPR165W RHO1 SGTC_3325 9138760 55.175 µM 0.100572928633762 0.475145767916963 no 1561 0.459944743769522 2108 43844959 SGTC_61 0978-8327 98.565 µM 0.0999751869197747 0.475347038056831 no 1562 0.460182012350596 2241 6150059 YHR072W ERG7 SGTC_2377 9073351 62.6 µM 0.0994650626000084 0.47551881085772 no 1563 0.46038451315617 2070 7337946 YHR072W ERG7 SGTC_344 k064-0035 6.43 µM 0.0993714140748849 0.475550345370948 no 1564 0.460421689333185 2084 5088750 SGTC_2972 9093619 59.92 µM 0.0992503628621743 0.475591107489861 no 1565 0.460469744220411 2033 25236256 SGTC_112 phenothiazine 287.218 µM 0.0971539606995633 0.476297078566954 no 1566 0.461302064527872 2237 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.  SGTC_1315 1237-0019 3.69 µM 0.0968836058388906 0.476388127016106 no 1567 0.461409414099777 2230 825140 SGTC_1124 fisetin 1.16336 µM 0.0959951560370331 0.476687342339088 no 1568 0.461762209859623 2083 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster. SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.0951150450917907 0.47698376223258 no 1569 0.462111724000045 2233 77254 SGTC_2211 7117706 200 µM 0.0946453627109743 0.477141955694531 no 1570 0.462298258649894 2246 822771 SGTC_561 1550-0330 72.9 µM 0.0941923807418224 0.47729452771265 no 1571 0.462478168576544 2140 6812934 SGTC_2351 9026858 72.31 µM 0.0930882469184587 0.477666432629083 no 1572 0.462916727245959 2213 1409300 SGTC_1162 k048-0130 20.1 µM 0.0915197411375877 0.478194785113987 no 1573 0.463539810450638 2106 6797406 SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.0907186133615008 0.478464660520624 no 1574 0.46385809014655 2185 390807 SGTC_682 0kpi-0099 17 µM 0.0907130375571958 0.478466538873036 no 1575 0.463860305436645 2125 1714895 YML126C ERG13 SGTC_348 k064-0012 10.7 µM 0.0896372279910572 0.478828961763189 no 1576 0.464287749905957 2232 5066323 SGTC_574 1315-0397 40 µM 0.0889502655780096 0.479060397496758 no 1577 0.464560717842489 2237 6794277 SGTC_1451 4152-0210 104 µM 0.0883874308854455 0.479250020210649 no 1578 0.464784375448425 2240 659563 SGTC_2436 5633522 8.09 µM 0.0867435579122211 0.479803878572517 no 1579 0.465437676337597 2262 5724242 SGTC_2907 7721985 69.9 µM 0.0865508888752919 0.479868795746574 no 1580 0.465514252166465 2173 3267881 SGTC_2105 5350118 200 µM 0.0854459030570399 0.480241115734671 no 1581 0.465953450604566 2169 2133313 SGTC_523 1934-0222 13.7 µM 0.085247625763573 0.480307926208063 no 1582 0.466032264234694 2215 1361595 SGTC_292 k038-0015 474 µM 0.0847733271351844 0.480467745618739 no 1583 0.466220799525397 2220 46368540 SGTC_2948 9070189 9.45 µM 0.0846413653608868 0.480512211946616 no 1584 0.466273256121713 2267 6473636 YDL196W YDL196W SGTC_1298 1079-1278 263 µM 0.0839894067437536 0.48073190188307 no 1585 0.466532427101187 2208 2840950 SGTC_1419 3993-2473 62.6 µM 0.0829789605907602 0.481072402597066 no 1586 0.466934134463074 2198 704026 SGTC_2199 6590217 200 µM 0.0825451915840951 0.481218578572407 no 1587 0.46710659161795 2220 703109 SGTC_2383 9036125 200 µM 0.08099056011144 0.481742495003096 no 1588 0.467724729891138 2150 79580 SGTC_2823 7987624 58.44 µM 0.0799056716209544 0.482108125084405 no 1589 0.468156139477552 2197 2239440 SGTC_1955 wogonin 32.4 µM 0.0797738354760957 0.482152557650532 no 1590 0.468208567126174 2235 5281703 A flavanone. SGTC_318 1488-0629 67.2 µM 0.0791193943342545 0.482373126376638 no 1591 0.468468828710714 2159 3662576 SGTC_2017 5132927 60.65 µM 0.0788945199250816 0.482448917881952 no 1592 0.468558261061289 2232 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis SGTC_1370 2001-0092 44.6 µM 0.0784933421855597 0.482584132105323 no 1593 0.468717813025333 2233 790957 SGTC_1356 1502-0781 85.8 µM 0.0781859595911906 0.482687734670426 no 1594 0.468840065224812 2205 567702 SGTC_1581 himbacine 57.9 µM 0.077714026379894 0.482846800898548 no 1595 0.469027768206893 2123 5281825 An alkaloid muscarinic receptor antagonist. SGTC_2646 retinol 96.75 µM 0.0775891732105164 0.482888883418443 no 1596 0.469077427472054 2239 445354 A vitamin A analog and teratogen. SGTC_2406 ethylparaben 405.7 µM 0.0772577713464216 0.483000585355086 no 1597 0.469209242020022 1928 8434 A possible steroid mimic. SGTC_1568 digitonin 820 nM 0.0768237291852698 0.483146885130773 no 1598 0.469381886680291 2285 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1 SGTC_3246 9135460 32.98 µM 0.0764241649338274 0.483281565667521 no 1599 0.469540822493065 2242 41446951 SGTC_2898 9056270 58.44 µM 0.0761637521633199 0.483369343646254 no 1600 0.469644410238026 2244 19154699 SGTC_3271 9137798 49.47 µM 0.0754832576104058 0.483598723428234 no 1601 0.469915109010829 2263 6498326 SGTC_1182 1222-0449 220 µM 0.0754096254783653 0.483623543531079 no 1602 0.46994440049675 2215 658318 SGTC_167 3672-0051 66.205 µM 0.0752945146290981 0.483662345510567 no 1603 0.469990192893604 2271 3237971 SGTC_2951 9072950 58.06 µM 0.0744281741810146 0.48395437960647 no 1604 0.470334845607509 2292 16488155 SGTC_1391 3442-0225 151 µM 0.073161751977259 0.484381292426432 no 1605 0.470838701144198 2228 5227075 SGTC_3279 9140807 49.47 µM 0.0717988946020367 0.484840733674784 no 1606 0.47138097626579 2253 45595718 SGTC_522 1273-0010 11.6 µM 0.0705722692663033 0.485254266126894 no 1607 0.471869090643583 2208 5705015 SGTC_2699 st077704 54.6 µM 0.0697941403911067 0.48551660512418 no 1608 0.472178755548326 2215 645852 SGTC_1893 st059353 36.1 µM 0.0695009699938621 0.485615446460537 no 1609 0.47229543028942 2140 3112488 SGTC_1945 st075991 56.6 µM 0.0693151565168021 0.485678093258501 no 1610 0.472369380799354 2113 1084980 SGTC_2496 diffractaic acid 79.83 µM 0.0679726081700973 0.486130742282241 no 1611 0.47290371967642 2290 94870 An apoptosis inducer which activates caspases. SGTC_1758 st042942 75.2445 µM 0.0676406610004849 0.486242663236277 no 1612 0.473035843352107 2277 669317 SGTC_331 k048-0133 24.5 µM 0.066700735666828 0.486559578972604 no 1613 0.473409974320365 2284 6813582 SGTC_37 0566-0070 1.56 µM 0.0666698214543842 0.48657000249945 no 1614 0.473422279915296 2268 1626686 SGTC_3341 9147222 25.867 µM 0.066468203861448 0.486637983313898 no 1615 0.473502535676274 2212 1939759 SGTC_1348 1493-0373 93.8 µM 0.0663882710575456 0.486664934924242 no 1616 0.473534353971365 2241 3010129 SGTC_2565 isoliquiritigenin 100 µM 0.064873995319816 0.48717552727521 no 1617 0.474137162847552 2078 638278 Binds to benzodiazepine receptor 65X better than valium. SGTC_1957 st077035 62.4 µM 0.0642405851278977 0.487389110512877 no 1618 0.474389330928502 2307 705593 SGTC_1250 0485-0349 40.2 µM 0.0636597282912176 0.487584976162285 no 1619 0.47462058591966 2244 6842794 YDL195W SEC31 SGTC_2045 5106652 78.05 µM 0.0635821364268491 0.487611140463432 no 1620 0.474651478011885 2278 673349 SGTC_1999 st074831 12.5 µM 0.0624986469736732 0.487976503158304 no 1621 0.475082869696956 2151 17112523 SGTC_1166 k206-0078 225 µM 0.0613103533082384 0.488377218396766 no 1622 0.475556022783875 2282 5404595 SGTC_2669 eugenol 100 µM 0.0609631283103932 0.488494311507284 no 1623 0.475694286879104 2293 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism. SGTC_1048 3161-0300 24.5 µM 0.0600944808833771 0.488787245859457 no 1624 0.476040192818854 2292 2165101 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.0583851755336576 0.489363693164558 no 1625 0.476720911419328 2260 521171 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.0569868595898165 0.48983527876656 no 1626 0.477277831329402 2252 6708760 SGTC_2326 6164455 177.58 µM 0.0569063732166706 0.489862423439041 no 1627 0.477309888724735 2259 2888790 SGTC_3100 9120536 49.47 µM 0.0548577291243761 0.490553360491826 no 1628 0.478125904204882 2328 16421196 SGTC_3052 9092717 49.47 µM 0.0544509401086723 0.490690559847364 no 1629 0.478287947341284 2255 25237534 SGTC_2667 digitoxin 100 µM 0.0540641818246044 0.490821004379753 no 1630 0.478442014627126 2321 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_2654 protoveratrine a 100 µM 0.0515614315288595 0.491665146692454 no 1631 0.479439075809673 2312 5702278 A heart drug and vasodilator. SGTC_78 0336-0123 156.75 µM 0.0511896519178905 0.491790545978278 no 1632 0.479587198804237 2158 6765896 SGTC_1565 sinapyl alcohol 95.1 µM 0.0501348896639291 0.492146316052681 no 1633 0.480007448377368 2255 5280507 A phenol propionate derived from cinnamic acid. SGTC_2940 9060638 45.86 µM 0.049053339688851 0.492511128079195 no 1634 0.480438394071916 2247 4027022 SGTC_2084 5306078 60.6385 µM 0.0484112512806375 0.492727710580971 no 1635 0.480694246297258 2273 679340 SGTC_1777 st045864 34.765 µM 0.0479619647870858 0.492879260449464 no 1636 0.48087327770243 2321 4691462 SGTC_2533 agelasine 13.65 µM 0.0465278530500372 0.493363010772928 no 1637 0.481444767298545 2315 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase. SGTC_1557 sumaresinolic acid 42.3 µM 0.0461208785958862 0.493500291999306 no 1638 0.481606952500425 2311 9982268 A natural terpine and antifungal of unknown mechanisn. SGTC_2364 9055074 200 µM 0.0454158709395441 0.49373810803982 no 1639 0.48188791542985 2278 6470630 SGTC_2971 9092186 9.93 µM 0.0454098636693929 0.493740134446222 no 1640 0.481890309513936 2244 25236400 SGTC_3085 9117376 49.47 µM 0.0447380621647882 0.49396675134281 no 1641 0.482158047418461 2223 16480349 SGTC_375 3970-0961 9.27 µM 0.0447273441162911 0.493970366847692 no 1642 0.482162319025257 2283 2898222 SGTC_3189 9110682 49.47 µM 0.0443088503708874 0.494111537164166 no 1643 0.48232910851446 2292 17122418 SGTC_1385 3091-4834 14.1 µM 0.0440012131440465 0.494215312769861 no 1644 0.482451718428271 2285 4072814 SGTC_1354 1498-1681 81 µM 0.0434417134781043 0.494404050408997 no 1645 0.482674713261383 2254 5754243 SGTC_1987 st072290 61.9 µM 0.0426934750024515 0.494656457806571 no 1646 0.482972940511316 2225 54697379 SGTC_1359 1582-0056 520 nM 0.0421659287324463 0.494834419181251 no 1647 0.483183211662209 2298 3661189 SGTC_1980 st071811 45.7 µM 0.0420620908482384 0.49486944776194 no 1648 0.483224600265027 2296 4974850 SGTC_922 1866-0035 480 µM 0.0416697760628899 0.495001791241984 no 1649 0.483380974116426 2202 3156169 SGTC_1570 verbenone 133 µM 0.0402173648266483 0.495491752360727 no 1650 0.483959916849981 2350 29025 A natural terpanoid with antifungal properties. SGTC_2748 diazoxide 86.69 µM 0.0400665174894234 0.495542640093381 no 1651 0.484020047764368 2314 3019 A potassium channel activatior. SGTC_2255 7941087 197.44 µM 0.039657140569033 0.495680742087354 no 1652 0.484183235823787 2352 935561 SGTC_1153 4055-0057 267 µM 0.0393372090753875 0.495788670314048 no 1653 0.484310770505321 2320 882706 SGTC_2325 6158266 200 µM 0.0391299174362942 0.495858599884183 no 1654 0.484393404281952 2283 3623240 SGTC_703 3875-0075 71.8 µM 0.0376990788438358 0.496341294814391 no 1655 0.484963805226163 2305 2850814 SGTC_1649 st011737 51.3 µM 0.0371519617882813 0.496525866792652 no 1656 0.485181920541989 2286 1761035 SGTC_1053 3366-3204 134 µM 0.0370356382043189 0.496565109084541 no 1657 0.485228295022353 2302 3632071 YPR165W RHO1 SGTC_1626 st003712 1.76 µM 0.0368056664621825 0.496642691198664 no 1658 0.485319977963994 2296 24207035 SGTC_2227 7312221 64.1025 µM 0.0363229440212919 0.49680554043102 no 1659 0.485512427662828 2313 887188 YOR168W | YOR169C GLN4 | YOR169C SGTC_1376 2910-0861 41.3 µM 0.0354892861233563 0.497086781025672 no 1660 0.485844794715054 2343 1112859 SGTC_202 3594-0513 34.79 µM 0.0351231453517668 0.497210301761147 no 1661 0.485990772737336 2334 708429 SGTC_787 4152-0075 138 µM 0.0351146239371955 0.497213176536806 no 1662 0.485994170194149 2235 9566539 SGTC_2602 kawain 100 µM 0.0327918515802203 0.49799678952315 no 1663 0.486920288108422 2351 5369129 SGTC_2124 5246320 200 µM 0.0325454162509034 0.498079927717873 no 1664 0.4870185491324 2318 579342 SGTC_3265 9137266 49.47 µM 0.0313450649437853 0.498484883120945 no 1665 0.48749717571028 2354 17224265 SGTC_704 1310-0270 142 µM 0.031161681156561 0.498546750369726 no 1666 0.487570299535019 2328 5718033 SGTC_2820 7989630 71.43 µM 0.0310575304671958 0.498581887169867 no 1667 0.487611829547127 2354 2984098 SGTC_3104 9120930 49.47 µM 0.0310348036928362 0.498589554390187 no 1668 0.487620891849848 2257 17014836 SGTC_2109 5483026 200 µM 0.030797553438466 0.498669594374621 no 1669 0.487715495784627 2318 759335 SGTC_52 0329-0193 875 nM 0.0304111896794389 0.49879994018264 no 1670 0.487869560455255 2326 3739292 SGTC_2866 9034245 58.44 µM 0.0285920481911568 0.499413657275688 no 1671 0.488594977058738 2364 6462273 SGTC_1692 fluoroquinolonic acid 71 µM 0.0284382123735937 0.499465556385295 no 1672 0.488656323724598 2308 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2 SGTC_1339 1486-1321 22.7 µM 0.0280972529127444 0.499580584845344 no 1673 0.488792292533983 2340 3469382 SGTC_2528 xanthyletin 44.79 µM 0.0277439239638799 0.499699786398747 no 1674 0.488933195458048 2335 65188 An natural product with antifungal activity of unknown mechanism. SGTC_2782 7736369 71.43 µM 0.027631957222627 0.499737560296652 no 1675 0.488977846606551 2326 2950836 YOL077C BRX1 SGTC_2032 5185112 25.99 µM 0.0275725846139363 0.499757590664092 no 1676 0.489001523829069 2352 5718189 SGTC_496 calpeptin 138 µM 0.0273292192502096 0.4998396941477 no 1677 0.489098575988191 2262 73364 A calpain inhibitor. SGTC_333 3486-0131 40.1 µM 0.0269197449738167 0.49997783733833 no 1678 0.489261872505901 2350 6744690 SGTC_1677 st019204 53.9 µM 0.0267883589890184 0.49997783733833 no 1679 0.489314269034226 2244 3945625 SGTC_378 3970-0959 8.33 µM 0.0263560795677354 0.499832000440205 no 1680 0.489486662698133 2336 6615653 SGTC_3124 9127567 49.47 µM 0.0260725871388145 0.499736359404116 no 1681 0.489599720960825 2363 17592030 SGTC_2251 lansoprazole 556 µM 0.0260420247241346 0.49972604864983 no 1682 0.489611909461635 2309 3883 Gastric proton pump inhibitor. YBR192W RIM2 SGTC_1322 1348-1070 12 µM 0.0258761187511863 0.499670077430391 no 1683 0.489678074071698 2343 6758089 SGTC_3145 9085516 49.47 µM 0.0249966811640096 0.499373384243692 no 1684 0.490028805415122 2285 25236195 SGTC_1106 tegaserod maleate 11.7 µM 0.0235720683464644 0.498892767753378 no 1685 0.490596976094617 2282 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. SGTC_942 3253-1115 227 µM 0.0233527849425968 0.49881878902721 no 1686 0.490684433440323 2349 46497897 SGTC_389 tpck 16.7 µM 0.0230163509356757 0.498705287771192 no 1687 0.49081861512182 2343 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.  SGTC_1732 st034308 51.822 µM 0.0223284131333636 0.498473201567331 no 1688 0.491092992063039 2363 830119 SGTC_797 k781-0471 270 µM 0.0210241096830687 0.49803317658943 no 1689 0.491613211589358 2297 23738129 SGTC_1825 st052143 62.6 µM 0.0201155811684521 0.497726673193221 no 1690 0.491975585342692 2363 674173 SGTC_2591 skatole 100 µM 0.0192079555514926 0.497420475740609 no 1691 0.492337605581064 2345 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite. SGTC_1035 k081-0041 55.2 µM 0.0184849750998414 0.497176571437452 no 1692 0.492625981826232 2364 731709 SGTC_2293 7624732 200 µM 0.0174385527444049 0.496823552837827 no 1693 0.493043376591516 2367 894453 SGTC_890 0929-0006 47.2 µM 0.017006952329195 0.49667794983945 no 1694 0.493215534709106 2365 1378169 SGTC_1044 1222-0021 1.78 µM 0.016463456342036 0.496494598828129 no 1695 0.493432327874506 2323 4306703 SGTC_1506 4226-2149 212 µM 0.0162652168551351 0.496427721956525 no 1696 0.493511403398761 2307 991114 SGTC_1932 st074806 40.9 µM 0.0157747355012401 0.496262256575638 no 1697 0.493707052039408 2341 17251235 SGTC_1362 1611-0397 101 µM 0.0156726725424677 0.496227825405046 no 1698 0.493747764235859 2380 27816 SGTC_2730 imipramine 71.33 µM 0.015569821844398 0.496193128517242 no 1699 0.493788790721854 2377 3696 A tricyclic antidepressant. SGTC_2471 5466956 24.79 µM 0.0152822788356925 0.496096125464293 no 1700 0.493903490137143 2318 724419 SGTC_3072 9116419 49.47 µM 0.0149393628555848 0.495980442561015 no 1701 0.49404027820179 2371 17170162 SGTC_323 4013-0906 34.3 µM 0.0145324133034511 0.495843158334715 no 1702 0.494202609957172 2375 2910086 SGTC_329 k048-0121 21.3 µM 0.0132136346523373 0.495398272487466 no 1703 0.494728675855508 2343 6832902 SGTC_959 1222-0044 107 µM 0.0128648489743313 0.495280611665753 no 1704 0.494867809380187 2383 6083612 SGTC_1846 st056244 14.8 µM 0.0124653653647016 0.49514584869642 no 1705 0.495027167499909 2334 5393182 SGTC_3243 9134147 49.47 µM 0.0117287281812498 0.494897350818221 no 1706 0.495321021709175 2385 24282180 SGTC_439 amiodarone 34.4 µM 0.0104312382518695 0.49445965922346 no 1707 0.495838613491777 2339 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1 SGTC_855 0428-0020 25 µM 0.0102342008894669 0.494393191765441 no 1708 0.495917215830226 2374 6812414 SGTC_1334 1486-0610 236 µM 0.0101219852149888 0.49435533764043 no 1709 0.495961981088519 2354 3742339 SGTC_2495 cafestol 54.53 µM 0.00867539358664078 0.493867358253129 no 1710 0.496539062112333 2365 16667697 An anti-infammatory. SGTC_2083 5306046 65.942 µM 0.00819600323450969 0.493705647284339 no 1711 0.496730304386166 2383 539837 SGTC_456 gingerol 170 µM 0.0080606134753398 0.493659976945385 no 1712 0.496784315301127 2380 442793 A herb. SGTC_683 panaxydol 45 µM 0.00748018645341105 0.493464185398993 no 1713 0.497015865187118 2387 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis. SGTC_474 dl-dihydrosphingosine 5 µM 0.00635312251793491 0.493084005035662 no 1714 0.49746548786477 2388 3058739 A sphingolipid protein kinase C inhibitor. SGTC_1651 st011928 86.1 µM 0.00517203306300671 0.492685607571299 no 1715 0.497936666534539 2390 720198 SGTC_33 0986-0033 35.816 µM 0.00495025255206718 0.492610798803822 no 1716 0.498025143023964 2399 2848082 SGTC_2769 toremifene 3.73 µM 0.0042707577971037 0.492381600108239 no 1717 0.498296219324698 2391 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue. SGTC_1340 1486-1359 257 µM 0.00424333365970623 0.492372349792563 no 1718 0.498307159873474 2382 4309068 SGTC_1512 0259-0544 12.2 µM 0.00369533981292779 0.492187509254651 no 1719 0.498525776063393 2393 18476 SGTC_2512 diallyl trisulfide 49.23 µM 0.00350330081278956 0.492122734119155 no 1720 0.498602388043657 2400 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent SGTC_944 3370-0224 231 µM 0.00333600184415751 0.492066304014582 no 1721 0.49866913028539 2396 4580514 SGTC_1232 0279-0259 161 µM 0.00314086198934025 0.492000483352755 no 1722 0.498746979415724 2399 1560000 SGTC_1791 st048313 56.1 µM 0.00240210914065227 0.491751304047513 no 1723 0.499041698023243 2398 1204976 SGTC_3166 9102297 49.47 µM 0.00205006541408497 0.491632561792692 no 1724 0.49918214280161 2399 25237072 SGTC_888 0916-0002 6.97 µM 0.00199457594135136 0.491613845591 no 1725 0.49920427985313 2399 2802138 YIL048W NEO1 SGTC_1571 st070080 73.4 µM 0 0.490941101990876 no 1726 0.5 2406 4315245 SGTC_361 000s-0510 1.45 µM -0.00175393019055021 0.490349546190172 no 1727 0.49930028344887 2412 660 SGTC_1142 3253-1408 9.78 µM -0.00197270507219233 0.490275760479563 no 1728 0.499213005050381 2397 256655 SGTC_3302 9125395 16.351 µM -0.00362008209599739 0.489720164212153 no 1729 0.498555799347757 2419 17599668 SGTC_1454 4239-0054 42.6 µM -0.00365841733664468 0.489707235458159 no 1730 0.498540505900709 2415 1340767 SGTC_2167 5876490 200 µM -0.00380839216333096 0.489656655792603 no 1731 0.498480675018376 2417 686534 SGTC_223 busulfan 5 mM -0.00446126528486757 0.489436473428601 no 1732 0.49822021855758 2417 2478 A DNA alkylator. SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM -0.00459324960109485 0.489391961924261 no 1733 0.498167564973123 2410 6708784 An antioxidant flavonoid SGTC_1269 0831-0796 3.05 µM -0.00609064302631201 0.488886977718251 no 1734 0.497570200004597 2423 927758 SGTC_2924 9010168 62.78 µM -0.00653955902136454 0.488735587748735 no 1735 0.497391112006421 2430 2993929 SGTC_605 1315-0399 119 µM -0.00778262944145401 0.488316390030201 no 1736 0.496895211405628 2428 24020461 SGTC_1473 k844-0725 134 µM -0.00811202611364654 0.488205310508252 no 1737 0.496763805296533 2415 54682906 SGTC_1586 deoxycorticosterone acetate 53.7 µM -0.00821061867843544 0.488172063188482 no 1738 0.496724473863821 2423 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE. SGTC_3324 9138759 60.749 µM -0.00842254735884313 0.48810059701698 no 1739 0.496639929476765 2458 45595710 SGTC_2040 5100729 123 µM -0.00917861448809857 0.487845640680304 no 1740 0.496338314019586 2425 11840 YJR013W | YDR381W GPI14 | YRA1 SGTC_495 decylubiquinone 155 µM -0.0103424530054314 0.487453187912706 no 1741 0.495874031769816 2446 2971 A Co-enzyme Q analog. A free radical scavenger. SGTC_1943 st076331 65.2 µM -0.0115607355120642 0.487042389353354 no 1742 0.49538803654388 2421 24208415 SGTC_2998 9066762 71.4286 µM -0.0134508762956518 0.486405071028937 no 1743 0.494634038544759 2444 4945196 SGTC_2601 securinine 100 µM -0.0136221381985321 0.486347326572305 no 1744 0.494565721190183 2432 442872 A GABA receptor antagonist. SGTC_3076 9116187 49.47 µM -0.0138598505945781 0.486267177446193 no 1745 0.494470896617618 2438 27241210 SGTC_1914 st062367 72.6 µM -0.0152792964616333 0.485788596705005 no 1746 0.49390467979335 2446 978205 SGTC_2305 7443522 69.23 µM -0.015837112663228 0.48560052881216 no 1747 0.493682170260431 2444 5415886 SGTC_2260 7964312 200 µM -0.0162170983253416 0.485472418368286 no 1748 0.493530597383149 2442 231951 SGTC_823 0417-1665 178 µM -0.0167431483795553 0.485295065454115 no 1749 0.493320762274296 2453 3429856 SGTC_1988 st071872 53.4 µM -0.0173505380785829 0.485090293250821 no 1750 0.493078484051359 2431 16414116 SGTC_1923 st058458 19.1 µM -0.0178460264831318 0.484923249777293 no 1751 0.492880843386338 2436 3534982 SGTC_3229 9132204 49.47 µM -0.0182192435321746 0.484797429259892 no 1752 0.492731975532661 2436 17682924 SGTC_2402 5553605 200 µM -0.0186805313352967 0.484641920048543 no 1753 0.492547979644806 2449 6758546 SGTC_3313 9133968 57.047 µM -0.0187081743728014 0.484632601109649 no 1754 0.492536953595241 2443 1494643 SGTC_2791 5663188 71.43 µM -0.0191237228047025 0.484492513667942 no 1755 0.49237120341384 2458 54690634 SGTC_1293 1000-1278 195 µM -0.0195433797216199 0.484351043138549 no 1756 0.492203815814159 2456 678847 SGTC_870 0573-2213 57.6 µM -0.0205104773842536 0.484025032407374 no 1757 0.491818077045684 2443 3916321 SGTC_743 1275-0778 158 µM -0.0208010786461447 0.483927072164905 no 1758 0.49170216864543 2457 2849257 YMR203W TOM40 SGTC_1759 st043059 70 µM -0.0236050907239756 0.482981904333647 no 1759 0.490583805736671 2465 669426 SGTC_1654 st012436 41.8 µM -0.0245466222911449 0.482664556930151 no 1760 0.490208297846819 2453 4323132 SGTC_546 peri-Naphthalide 147 µM -0.0257238232127424 0.482267791596383 no 1761 0.489738810983263 2478 223824 A penicillin ester. SGTC_2583 asiatic acid 100 µM -0.026147005363356 0.482125166003254 no 1762 0.489570042502575 2491 5320556 A kinase inhibitor; arrests cells at G2/M. SGTC_502 l-744,832 89.3 µM -0.0275450816341785 0.481653987026027 no 1763 0.489012491764725 2461 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.  SGTC_2906 7926292 26.41 µM -0.0280268882533484 0.481491614700292 no 1764 0.488820352920987 2483 2966319 SGTC_2635 hydroquinidine 100 µM -0.0299426219175275 0.48084602919729 no 1765 0.488056406850207 2472 442912 An experimental heart treatment. SGTC_3236 9132701 49.47 µM -0.0300430737573037 0.480812179176431 no 1766 0.488016350385061 2467 24282524 SGTC_2523 spermine 47.74 µM -0.0300838188680629 0.480798449025827 no 1767 0.4880001027817 2464 1103 A DNA binding polyamine. SGTC_2812 7970281 58.44 µM -0.0313668097761289 0.480366122793854 no 1768 0.487488505040805 2495 2233435 SGTC_573 3702-0553 84.7 µM -0.0318652078889093 0.480198185030495 no 1769 0.487289772311862 2463 1222756 SGTC_821 1114-0266 29.2 µM -0.033015714668041 0.479810529426455 no 1770 0.486831027990069 2495 3123235 SGTC_1863 st057641 20.1 µM -0.0338264950163805 0.479537353830921 no 1771 0.486507754031969 2454 3921635 SGTC_698 k064-0052 127 µM -0.0349947661567191 0.479143746074454 no 1772 0.486041957160297 2453 5088751 SGTC_303 1348-1668 34.2 µM -0.0359070467191838 0.478836399436835 no 1773 0.485678238511527 2489 5380509 SGTC_3228 9131799 49.47 µM -0.0361683951236259 0.478748353666231 no 1774 0.485574043265434 2497 17015818 SGTC_1793 st048256 72.231 µM -0.0362303821610872 0.478727470979887 no 1775 0.485549330212603 2462 672022 SGTC_2576 guaiol 23.12 µM -0.0367271341948032 0.478560123316644 no 1776 0.485351286637632 2517 227829 SGTC_2619 obliquin 87.91 µM -0.0374207794761863 0.478326451858028 no 1777 0.485074752323349 2479 6708593 A bioactive alkalod. YER133W GLC7 SGTC_2517 totarol 10 µM -0.0390555146521549 0.477775780754127 no 1778 0.484423064026046 2517 460178 An antibacterial membrane disruptor. YGL001C ERG26 SGTC_1413 3910-0535 34.4 µM -0.0397053668739986 0.477556885562515 no 1779 0.484164011453035 2519 2876951 SGTC_1180 1193-0155 285 µM -0.0421108501597799 0.476746685821519 no 1780 0.483205165333981 2526 2921347 SGTC_2007 4011539 71.82 µM -0.0431641097084438 0.476391963627431 no 1781 0.482785357356595 2483 45595301 SGTC_887 0885-0007 9.62 µM -0.0432665996176674 0.476357447540366 no 1782 0.482744507960813 2599 5719458 SGTC_667 1498-1044 59 µM -0.044241582595459 0.476029106099564 no 1783 0.482355918183872 2520 6739982 SGTC_1256 0570-0116 285 µM -0.0460225362389782 0.475429383050764 no 1784 0.481646143808675 2500 410638 SGTC_1475 4092-1048 11.7 µM -0.0460754163130482 0.475411576918699 no 1785 0.481625070066711 2519 2881759 SGTC_215 1287-0124 461.5 µM -0.0469552650937719 0.475115315588328 no 1786 0.481274440728579 2556 5560863 SGTC_2099 5377090 177.372 µM -0.0473613151737902 0.474978595658931 no 1787 0.481112630210437 2546 2243829 SGTC_2776 terbinafine 19.92 µM -0.0473756120474451 0.474973781854212 no 1788 0.481106932978288 2481 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_3180 9109287 49.47 µM -0.0491442907360829 0.474378290284164 no 1789 0.480402153562461 2557 18891271 SGTC_3182 9108849 49.47 µM -0.0502029120126695 0.474021893291908 no 1790 0.479980345515767 2544 17133045 SGTC_272 doxorubicin 8.13 µM -0.0505784647866715 0.473895464125261 no 1791 0.47983071173388 2472 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1620 st003704 16.5 µM -0.0508501091662981 0.473804017170826 no 1792 0.479722480577437 2496 2834414 SGTC_1224 0823-0416 294 µM -0.0510317752125965 0.473742861488069 no 1793 0.479650100284398 2547 3598164 SGTC_3012 9080433 71.4286 µM -0.0534480263532899 0.47292951910241 no 1794 0.478687470186961 2500 17688859 SGTC_415 dibenzyl ketone 100 µM -0.0538475899375664 0.472795031449635 no 1795 0.478528296603169 2597 7593 SGTC_1926 methyl fluorone black 53.6 µM -0.0539282394265721 0.472767886307283 no 1796 0.478496168794093 2489 72721 Reacts with homocysteine. SGTC_2683 piperine 63.03 µM -0.0541799256231818 0.472683174152391 no 1797 0.478395907110673 2504 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_1739 st037196 92.5 µM -0.0549699967653491 0.472417261260851 no 1798 0.478081183375613 2514 612214 SGTC_2244 6635614 200 µM -0.055894620236625 0.472106077942548 no 1799 0.477712878280523 2509 836499 SGTC_1985 st071382 65.5 µM -0.0591018129833792 0.471026825913446 no 1800 0.476435507308066 2514 6123237 SGTC_3137 9097352 49.47 µM -0.0591999641797422 0.47099380038147 no 1801 0.476396419087302 2575 44120435 SGTC_711 k292-0785 179 µM -0.0595462097429557 0.470877298618557 no 1802 0.47625853034791 2510 4146315 SGTC_2080 5212524 12.4 µM -0.0595901559832914 0.47086251213933 no 1803 0.476241029412021 2518 260183 SGTC_1790 st045711 43.5 µM -0.0607261957828058 0.470480285729672 no 1804 0.475788634479161 2517 585119 SGTC_1400 3771-8998 51.5 µM -0.0619778486143756 0.47005919222428 no 1805 0.475290236163199 2540 670767 SGTC_1421 4029-0249 71.4 µM -0.062337141825847 0.469938321389727 no 1806 0.475147175539194 2554 2894095 SGTC_3136 9095672 49.47 µM -0.0640413227857553 0.469365051020995 no 1807 0.474468661747636 2489 17217380 SGTC_73 0327-0325 16.231 µM -0.0648145056723715 0.469104980474802 no 1808 0.474160845939725 2652 53298 SGTC_2015 5119600 184 µM -0.0655640403625244 0.468852876902044 no 1809 0.473862459559774 2569 2828786 SGTC_1606 st000094 49.2 µM -0.065890015700095 0.468743240040544 no 1810 0.473732694813352 2509 1242210 SGTC_2825 7998094 58.44 µM -0.0666954329404631 0.468472360346495 no 1811 0.473412085101841 2577 2987815 SGTC_131 0141-0277 33.849 µM -0.0702796289309422 0.467267094419513 no 1812 0.471985548083857 2604 1547771 SGTC_1725 st036284 20.55 µM -0.071312641735885 0.466919776014212 no 1813 0.47157446709795 2554 707914 SGTC_760 0568-0725 82.9 µM -0.0714334034329063 0.466879175291267 no 1814 0.471526412704337 2542 3916171 SGTC_287 k060-0039 29.6 µM -0.0721507611771057 0.466638002931672 no 1815 0.471240964938384 2574 5861974 SGTC_2065 5221596 34.26 µM -0.0723560769978583 0.466568978951948 no 1816 0.471159269303696 2629 788581 SGTC_1681 tripelennamine 100 µM -0.073208915095008 0.466282278857992 no 1817 0.470819936103457 2521 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist. SGTC_1749 st037932 54.2 µM -0.0773765564110043 0.464881489911055 no 1818 0.469161995066586 2640 594497 SGTC_346 4513-0042 7.16 µM -0.077707317916125 0.464770335830067 no 1819 0.469030436427927 2569 2827372 SGTC_412 gemfibrozil 100 µM -0.0827892405399202 0.463062880754735 no 1820 0.467009562281169 2535 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels. SGTC_1844 rapamycin 4 nM -0.0832976183148752 0.462892109829372 no 1821 0.46680744701218 2546 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2 SGTC_3239 9133757 49.47 µM -0.0837594366631329 0.462736984768034 no 1822 0.466623849747707 2549 17036923 SGTC_2176 5809774 33.9695 µM -0.0837727571095488 0.46273251050603 no 1823 0.466618554269613 2606 2870539 SGTC_2804 7954240 19.48 µM -0.0840177609268839 0.462650215962187 no 1824 0.466521155259406 2628 828705 SGTC_2745 rifampicin 24.3 µM -0.0850116330798913 0.462316399818447 no 1825 0.466126071165342 2624 25141428 Inhibits bacterial DNA-dependent RNA polymerase. SGTC_2707 st078556 66.6 µM -0.0853976831925924 0.462186742639216 no 1826 0.465972617490267 2596 17250899 SGTC_2114 5491910 81.25 µM -0.0859224219739806 0.462010512507844 no 1827 0.465764043632458 2633 2849228 SGTC_1967 st070177 51.4 µM -0.0865538194114393 0.461798471644482 no 1828 0.465513087422602 2647 5729214 SGTC_1229 0139-0193 12.2 µM -0.08687305075337 0.461691268988257 no 1829 0.465386210449346 2576 3090752 SGTC_2393 9031399 185.94 µM -0.0871913707002452 0.461584375163468 no 1830 0.465259699209219 2635 1526623 YDL150W RPC53 SGTC_2338 7999974 200 µM -0.0875461204600436 0.461465251250117 no 1831 0.465118713652335 2658 315925 SGTC_2962 9082311 13.18 µM -0.0881674567298223 0.461256616717111 no 1832 0.464871791163798 2576 16459453 SGTC_2952 9073731 13.78 µM -0.088422777539382 0.461170887262825 no 1833 0.464770329170165 2578 16457353 SGTC_2291 7917025 104.35 µM -0.0895779965544446 0.460783020237577 no 1834 0.464311285152005 2587 2964612 SGTC_1316 1272-0050 65.9 µM -0.0900416348319228 0.460627363256881 no 1835 0.464127064685071 2574 7340392 SGTC_1272 0839-0021 27 µM -0.0906851287444441 0.460411333461801 no 1836 0.463871393740135 2651 5027250 SGTC_207 4185-0010 4.486 µM -0.0907598317955384 0.460386255371427 no 1837 0.463841713927118 2566 3761753 SGTC_1621 st003705 32.4 µM -0.0908926667417919 0.460341662578246 no 1838 0.463788938582999 2563 24207032 SGTC_2356 9061756 188.97 µM -0.0909344168405154 0.460327647141126 no 1839 0.463772351394062 2567 20104043 SGTC_433 pimozide 108 µM -0.0913100192044863 0.460201560284903 no 1840 0.463623128537101 2557 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic SGTC_1505 k297-0037 20.6 µM -0.0922366002823351 0.459890531205487 no 1841 0.463255029577916 2592 4089396 SGTC_3062 9077494 49.47 µM -0.0955493653623701 0.458778724509779 no 1842 0.461939240848944 2619 16459633 SGTC_325 2810-4341 181 µM -0.0965869911560393 0.458430549798622 no 1843 0.461527193871169 2625 774970 SGTC_1228 0124-0032 52.5 µM -0.0967357469696418 0.458380637482273 no 1844 0.461468125483691 2631 X1228 SGTC_1524 corynanthine 62.1 µM -0.0971369848416294 0.45824601266299 no 1845 0.461308805034291 2770 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist. SGTC_1984 st072354 53.1 µM -0.0972104294071543 0.458221370788045 no 1846 0.461279642902446 2598 5762938 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.0986355387369999 0.457743254773035 no 1847 0.460713825882264 2621 279621 SGTC_1292 0kpi-0043 232 µM -0.101394477184407 0.456817821103621 no 1848 0.459618660224843 2619 3333905 SGTC_719 2810-4230 27.3 µM -0.104046139629989 0.455928591735367 no 1849 0.458566366557007 2593 721079 SGTC_701 4424-0219 185 µM -0.104563856908471 0.455755001959194 no 1850 0.458360947722864 2639 2911779 SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.104668241846564 0.455720002878327 no 1851 0.458319531419625 2792 804 An inhibitor of viral and cellular DNA polymerases. SGTC_2013 4024628 200 µM -0.105698455900929 0.455374602312751 no 1852 0.45791080275099 2701 5230760 SGTC_1190 1486-1332 13 µM -0.105746663861158 0.455358440421261 no 1853 0.457891677739236 2569 4150046 SGTC_2506 ethyl hematommate 54.16 µM -0.105872583320879 0.455316225819568 no 1854 0.457841723562401 2659 3940691 An allergen. SGTC_1734 st037168 69.4 µM -0.106459476228514 0.455119476156677 no 1855 0.457608902961751 2698 708907 SGTC_2877 9040724 71.43 µM -0.106774298288155 0.455013939911935 no 1856 0.457484018941129 2604 6463895 SGTC_158 k038-0087 26.446 µM -0.107576893317812 0.45474490432458 no 1857 0.457165663530838 2592 X158 SGTC_664 1222-0054 14.9 µM -0.108028876985739 0.454593405298796 no 1858 0.45698639286317 2630 6813991 SGTC_1891 st059073 26.2 µM -0.108084562954256 0.454574740545573 no 1859 0.456964306694893 2640 688754 SGTC_2235 salicylic acid 500 µM -0.110047861120296 0.453916749126099 no 1860 0.456185708852077 2604 338 A COX inhibitor and kinase inhibitor. SGTC_2116 5511452 16.8835 µM -0.110164607235969 0.453877626104717 no 1861 0.456139415359581 2714 870744 SGTC_3029 9088683 49.47 µM -0.111983785294327 0.453268055810262 no 1862 0.455418131578311 2728 25236615 SGTC_2888 9058547 12.99 µM -0.112416983848562 0.453122915788435 no 1863 0.4552463947609 2633 16476514 SGTC_479 n-linoleoylglycine 10 µM -0.114737375006913 0.452345592701039 no 1864 0.45432664428566 2615 6433346 An anti-infammatory. SGTC_271 rotenone 740 µM -0.117176674072807 0.451528632817204 no 1865 0.453360025479341 2749 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria. SGTC_2648 atorvastatin 78.68 µM -0.117424579502018 0.451445616794841 no 1866 0.453261803591068 2638 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11 SGTC_2184 6075246 200 µM -0.117486182012673 0.451424988308415 no 1867 0.453237396682982 2662 2267320 SGTC_2093 5331342 194.4 µM -0.11879386635847 0.450987122437033 no 1868 0.452719334105491 2702 33839 SGTC_408 cantharidin 100 µM -0.119344280422619 0.450802839238769 no 1869 0.452501301728271 2671 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_2429 5902844 64.44 µM -0.11978647398422 0.450654796843303 no 1870 0.452326148491854 2757 1927790 YGL093W | YPR107C SPC105 | YTH1 SGTC_1828 st055811 49 µM -0.120758472130235 0.450329404834255 no 1871 0.451941171877241 2640 5877589 SGTC_2159 5658611 73.75 µM -0.121534927432945 0.450069497912484 no 1872 0.451633675821892 2609 793844 SGTC_1185 1319-0113 81.3 µM -0.122008014218061 0.449911149603991 no 1873 0.451446335631933 2717 4672763 SGTC_2994 9053520 71.4286 µM -0.122262921422218 0.449825832147306 no 1874 0.451345398032194 2719 4647384 SGTC_746 1095-0025 46.6 µM -0.124881824823255 0.448949420029097 no 1875 0.450308553703898 2739 6749286 SGTC_3188 9110789 49.47 µM -0.125712884989218 0.448671358832331 no 1876 0.449979601021142 2747 849217 SGTC_2723 salbutamol 83.58 µM -0.126251769333958 0.448491069075805 no 1877 0.449766316585043 2714 9884233 β2-adrenoceptor agonist SGTC_1285 0929-0069 65.5 µM -0.126281903795748 0.448480987569858 no 1878 0.449754390127722 2665 1206237 SGTC_1794 st048918 76.9 µM -0.126639052350583 0.448361505798565 no 1879 0.449613043228005 2592 672303 SGTC_3109 9122853 49.47 µM -0.127380558836665 0.448113454502609 no 1880 0.449319601344521 2696 1234709 SGTC_733 4069-0007 56.1 µM -0.128357355761585 0.447786724020099 no 1881 0.448933088551462 2644 5717425 YNL287W SEC21 SGTC_3015 9080845 49.47 µM -0.128441475544836 0.447758588302689 no 1882 0.448899805109475 2735 5296973 SGTC_3007 9078383 71.4286 µM -0.12873896718817 0.447659087768558 no 1883 0.448782100299996 2675 6496995 SGTC_2887 9044784 58.44 µM -0.128915831420931 0.447599934438629 no 1884 0.448712124770115 2647 6465546 SGTC_1125 tnp00248 1.32998 µM -0.129134861853436 0.447526679979439 no 1885 0.448625468586551 2785 24207736 SGTC_642 0335-0876 158 µM -0.134177123361914 0.44584080168958 no 1886 0.446631257615145 2641 6812350 SGTC_2867 9039098 71.43 µM -0.134295515292279 0.445801229032262 no 1887 0.446584449699051 2625 6463460 SGTC_2111 5486399 200 µM -0.135189840473967 0.445502317143661 no 1888 0.446230889739992 2638 689674 SGTC_1786 berberine 21.6 µM -0.135694626101415 0.445333615415504 no 1889 0.446031348088063 2636 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_3203 9113543 49.47 µM -0.13730574043902 0.444795239797894 no 1890 0.445394566599676 2826 17018012 SGTC_3263 9137018 49.47 µM -0.137635321306618 0.444685118411927 no 1891 0.445264319405582 2672 43844957 SGTC_1003 4049-0218 100 µM -0.137890153902609 0.444599975258922 no 1892 0.445163616060096 2784 295161 SGTC_1159 4092-0538 61.2 µM -0.137962266053558 0.444575882039319 no 1893 0.445135119818462 2661 717301 SGTC_3223 9129970 49.47 µM -0.138391445168934 0.44443249426282 no 1894 0.444965528863948 2672 17248386 SGTC_332 4112-0506 40.9 µM -0.139326269577094 0.444120196727808 no 1895 0.444596166103103 2663 2790355 SGTC_616 4092-0450 108 µM -0.139874425459044 0.443937089978968 no 1896 0.444379604071044 2706 787165 SGTC_2278 7948257 134.34 µM -0.141429722428176 0.443417621704636 no 1897 0.443765237575496 2651 1247028 SGTC_2758 dehydroepiandrosterone 69.35 µM -0.141799599762462 0.443294097168982 no 1898 0.443619150109163 2715 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem] SGTC_3241 9133421 49.47 µM -0.141980068387201 0.443233829719627 no 1899 0.443547874652526 2635 17018221 SGTC_246 cycloheximide 667 µM -0.142506939719151 0.443057888696332 no 1900 0.443339799106653 2646 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells. SGTC_2470 5664817 21.68 µM -0.1429717438401 0.442902683435782 no 1901 0.443156248526679 2659 2859561 SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.143080727852098 0.442866293261349 no 1902 0.443113212637192 2737 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks. SGTC_611 3453-1652 23.7 µM -0.143757640770098 0.442640280278999 no 1903 0.442845926555374 2690 1560575 SGTC_1438 4092-1045 4 µM -0.145287699459943 0.442129481200529 no 1904 0.442241863044279 2657 1351342 SGTC_1267 0828-0272 9.49 µM -0.146366367354983 0.441769433457297 no 1905 0.441816088151539 2766 745334 SGTC_31 0508-1974 57.237 µM -0.147222430780865 0.441483722916881 no 1906 0.441478228151648 2700 6810525 SGTC_2324 6149169 200 µM -0.148259008418379 0.441137806657847 no 1907 0.441069182161327 2745 2888231 SGTC_588 3970-1144 52.9 µM -0.148720873191137 0.440983692237801 no 1908 0.440886944990449 2817 1888707 SGTC_191 3914-0123 66.505 µM -0.14880842578368 0.440954478812683 no 1909 0.440852400928177 2670 3144412 SGTC_1851 st056236 18.9 µM -0.149596283186944 0.440691611141875 no 1910 0.440541570385952 2677 5393171 SGTC_3074 9116018 49.47 µM -0.150159898211023 0.440503577697116 no 1911 0.440319231847159 2641 17027303 SGTC_2843 9000894 45.46 µM -0.151981504797438 0.439895944617633 no 1912 0.439600761608093 2644 2242070 SGTC_2690 usnic acid 100 µM -0.153434580670771 0.439411343698861 no 1913 0.439027788153649 2834 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_575 k072-0246 11.9 µM -0.153631273772576 0.439345753493772 no 1914 0.438950238382353 2672 6796779 SGTC_3153 9100258 49.47 µM -0.154262959726416 0.439135119799911 no 1915 0.438701200765849 2721 25236848 SGTC_185 k048-0037 25.491 µM -0.154278654295426 0.439129886714409 no 1916 0.438695013604126 2675 6827589 SGTC_274 sirtinol 40.1 µM -0.154308720839538 0.439119861569428 no 1917 0.438683160719598 2721 6836442 NAD-dependent acetyltransferase inhibitor. SGTC_603 3794-0023 45.9 µM -0.154772893213919 0.438965096650811 no 1918 0.438500180875129 2713 3802260 SGTC_1089 terbinafine 2.25 µM -0.155247187463468 0.438806966522325 no 1919 0.438313224498407 2793 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1 SGTC_362 0310-0100 9.03 µM -0.158754302745327 0.437637995897868 no 1920 0.436931226616798 2808 790235 SGTC_3238 9133470 49.47 µM -0.160034135516191 0.437211544681739 no 1921 0.436427092245452 2821 3534688 SGTC_553 k007-0256 45.7 µM -0.161088121427815 0.436860402314509 no 1922 0.436011997894474 2740 6287000 SGTC_2845 9003024 42.97 µM -0.161692202531803 0.436659171110839 no 1923 0.435774122608733 2922 2990173 SGTC_1050 3232-1156 69.3 µM -0.163087647829279 0.436194383797992 no 1924 0.435224712596806 2737 700529 SGTC_2387 9077560 195.08 µM -0.166159282601995 0.435171611683755 no 1925 0.434015800863675 2688 5303272 SGTC_67 0335-0847 266 µM -0.166375417797788 0.435099660700027 no 1926 0.433930759040965 3089 4552207 YOR254C SEC63 SGTC_834 0312-0008 75.7 µM -0.169950618488281 0.433909796908401 no 1927 0.432524486155838 2685 6385573 YIL048W NEO1 SGTC_1055 3448-0672 86 µM -0.17021022900036 0.433823419025967 no 1928 0.432422403762382 2857 748378 SGTC_2463 5473429 200 µM -0.173707077607587 0.432660253478896 no 1929 0.431047837483115 2779 5399405 SGTC_963 1269-2853 151 µM -0.174721157203198 0.432323046288091 no 1930 0.430649371224517 2751 3668223 SGTC_81 0411-0046 9.971 µM -0.175671371362781 0.432007120701847 no 1931 0.430276063919253 2697 12925265 SGTC_2336 9001819 198.65 µM -0.176462568691171 0.43174409792323 no 1932 0.429965276525758 2930 2989602 SGTC_1636 st007707 68.9 µM -0.177148509681978 0.431516090662857 no 1933 0.429695869604978 2857 403051 SGTC_2957 9076800 11.52 µM -0.177961906874175 0.431245746447649 no 1934 0.429376446026045 2784 16459615 SGTC_556 4058-0063 51.5 µM -0.17874511482137 0.430985466494915 no 1935 0.429068921546339 2722 6615692 SGTC_1968 st069590 43.6 µM -0.17886201860888 0.430946618956196 no 1936 0.429023023278619 2840 6384066 SGTC_2708 st078559 56 µM -0.180828540035791 0.430293237423482 no 1937 0.428251080337828 2756 17250902 SGTC_2373 9071805 200 µM -0.182059090347183 0.429884481028655 no 1938 0.42776817664855 2749 10149009 SGTC_1545 lovastatin 49.4 µM -0.182226375853573 0.429828918982781 no 1939 0.427702537292894 2770 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12 SGTC_249 wiskostatin 11.211 µM -0.182579759172189 0.429711551160009 no 1940 0.427563883603868 2729 2775510 A n-wasp and actin depolymerizer. SGTC_1422 4031-0024 15.5 µM -0.183307842194604 0.429469755381329 no 1941 0.427278240737418 2729 782427 SGTC_2162 5663267 200 µM -0.186310704413043 0.428472787842266 no 1942 0.426100556762343 2805 6456493 SGTC_1008 4106-0037 6 µM -0.186393256997285 0.428445386324791 no 1943 0.426068189955704 2705 2905394 SGTC_1137 ixabepilone 100 µM -0.186639836896734 0.428363541596643 no 1944 0.425971515101454 2724 154225 A novel microtubule stabilizer. SGTC_1297 1068-0111 14.1 µM -0.186806401322016 0.428308257324693 no 1945 0.425906213871125 2719 767057 SGTC_1021 4476-0760 85.3 µM -0.187510431018058 0.428074598917104 no 1946 0.425630222983963 2748 746768 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM -0.18822946709424 0.427835986114019 no 1947 0.42534838696209 2815 279621 SGTC_1240 0356-0016 42.1 µM -0.188443366235111 0.427765008570254 no 1948 0.425264553623664 2811 4305613 SGTC_2180 6301957 200 µM -0.190231361465087 0.427171794845841 no 1949 0.424563918454862 2793 845462 SGTC_2247 cerulenin 830 nM -0.190555112939688 0.427064399475659 no 1950 0.42443708018136 2970 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12 SGTC_2323 6148992 148.28 µM -0.193632187778484 0.426043938111022 no 1951 0.423231946475958 2810 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42 SGTC_369 0957-0393 4.5 µM -0.194541541498409 0.425742460331835 no 1952 0.422875935797012 2815 6997992 SGTC_2846 9008642 19.48 µM -0.19467196061544 0.425699226073901 no 1953 0.422824882056468 2885 2992898 SGTC_2303 7774051 200 µM -0.195124048530616 0.425549364736694 no 1954 0.422647918200875 2914 2953184 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.195961744245666 0.425271707808781 no 1955 0.422320054540455 2937 688798 SGTC_2582 agaric acid 100 µM -0.196217354460855 0.425186992357326 no 1956 0.422220022594379 2857 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase. SGTC_843 0310-0051 143 µM -0.198432567620992 0.424452961854423 no 1957 0.42135331937311 2776 2065037 SGTC_593 1203-0218 61.7 µM -0.198527015148943 0.424421671633531 no 1958 0.421316375169158 2888 3666956 SGTC_3284 9108171 64.8615 µM -0.200158501766054 0.423881239694933 no 1959 0.420678310585958 2868 8687505 SGTC_231 b-estradiol 524 µM -0.202491322590359 0.423108738818744 no 1960 0.4197663207387 2782 450 A steroid. SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM -0.202625233654406 0.423064403842075 no 1961 0.419713982752735 2740 364106 SGTC_814 3342-0569 96 µM -0.204910833822317 0.422307843112032 no 1962 0.41882089532743 2759 4346283 SGTC_3196 9111891 49.47 µM -0.205251007653106 0.422195265976096 no 1963 0.418688009658804 2725 18891510 SGTC_980 1473-0395 201 µM -0.20550340954289 0.422111740195821 no 1964 0.418589417258437 2769 768876 SGTC_22 0964-0034 14.468 µM -0.207619114247238 0.421411741360356 no 1965 0.417763189278409 2805 138402 SGTC_3162 9099653 49.47 µM -0.210076725784668 0.420598931611928 no 1966 0.416803895144535 2806 25237511 SGTC_2466 5983409 37.09 µM -0.210465728941992 0.420470306916332 no 1967 0.416652098474781 2818 2879657 SGTC_2119 5528445 120.635 µM -0.211487990913101 0.420132334401372 no 1968 0.416253251078925 2914 791935 SGTC_2345 9052315 157.45 µM -0.212481094998224 0.419804058231712 no 1969 0.415865862533881 2874 6469265 SGTC_1572 epiandrosterone 68.9 µM -0.212672878181384 0.419740669637155 no 1970 0.415791061443865 2770 441302 A steroid. SGTC_2090 5301565 104.445 µM -0.21360573009292 0.419432371123117 no 1971 0.415427265281946 2802 2056344 SGTC_3119 9125183 49.47 µM -0.214323049905692 0.419195337501667 no 1972 0.415147572204406 2848 22695334 SGTC_2242 6630449 61.2675 µM -0.215234971598874 0.418894041313234 no 1973 0.414792063211415 2971 691249 YDR170C SEC7 SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.215487424334933 0.418810640086486 no 1974 0.414693657849977 2814 115019 SGTC_197 4544-0043 41.561 µM -0.215687034101467 0.418744698843042 no 1975 0.414615854317735 2795 896523 SGTC_3022 9087993 49.47 µM -0.216876849793003 0.418351689716139 no 1976 0.414152159709137 2803 17173644 SGTC_1671 st016596 74.5 µM -0.217209801816555 0.418241726600912 no 1977 0.414022423144847 2822 2829167 SGTC_1478 0453-0656 35.7 µM -0.21824318686868 0.417900474198406 no 1978 0.413619818857524 2815 5258496 SGTC_792 4534-1957 155 µM -0.220717160326852 0.417083751121938 no 1979 0.41265633447815 2845 1717904 SGTC_1778 st046819 58.9 µM -0.22112591915035 0.4169488435241 no 1980 0.412497194591556 2811 671715 SGTC_1767 st044992 70.3 µM -0.221180300158411 0.416930896241709 no 1981 0.412476023808062 2860 9600693 SGTC_3244 9134489 49.47 µM -0.221208448198787 0.416921606654224 no 1982 0.412465065742899 2860 16584271 SGTC_1558 st069300 45.6 µM -0.221872077246935 0.416702605209081 no 1983 0.412206733960699 2872 24208000 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.222666158182364 0.416440587859228 no 1984 0.411897670987987 2834 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. SGTC_403 arphamenine a 50 µM -0.223751395016641 0.416082559886928 no 1985 0.411475376097006 2797 5487158 An arginine aminopeptidase inhibitor. SGTC_906 1165-0455 526 µM -0.22415671375915 0.415948859961585 no 1986 0.411317681926564 2802 3252859 SGTC_3230 9131665 49.47 µM -0.224182804592611 0.415940253876742 no 1987 0.411307531462038 2794 15943720 SGTC_2157 5649910 96.377 µM -0.225493440765981 0.415507991314871 no 1988 0.41079771374973 2821 2858091 SGTC_1887 st057648 70.8 µM -0.226787352842521 0.415081344824302 no 1989 0.410294549233436 2951 688672 SGTC_1683 st010134 710 nM -0.227591830756446 0.414816131744553 no 1990 0.409981785706879 2794 3818134 SGTC_3195 9113082 49.47 µM -0.22761626265294 0.41480807786234 no 1991 0.409972288011498 2848 17018038 SGTC_3277 9138724 49.47 µM -0.228022647462801 0.414674119901648 no 1992 0.409814317066061 2873 15943418 SGTC_377 3970-0964 33.1 µM -0.228321931499583 0.414575472264309 no 1993 0.409697987965888 2793 16481235 SGTC_1548 st061468 90.8 µM -0.229842018438671 0.414074516527225 no 1994 0.409107266325432 2933 390799 SGTC_2810 7959871 45.46 µM -0.230420207417715 0.413884006782087 no 1995 0.408882630158478 2924 2974535 SGTC_2054 5233173 129 µM -0.230436117500066 0.413878764793198 no 1996 0.408876449245966 2980 6889 SGTC_227 fluconazole 33.516 µM -0.23064504626874 0.41380992922085 no 1997 0.408795284551187 2841 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C SGTC_730 1436-0052 41.2 µM -0.231360748851005 0.413574147425507 no 1998 0.40851727791905 2814 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2 SGTC_1531 st059297 52.4 µM -0.232909178734439 0.413064137830038 no 1999 0.407915965416932 2939 7566702 SGTC_1181 1222-0449 220 µM -0.233045202599487 0.413019342361085 no 2000 0.40786315266745 3004 658318 SGTC_2980 9014342 25.29 µM -0.234235860701701 0.412627282454162 no 2001 0.407400938235303 2994 2996599 SGTC_2190 6049624 200 µM -0.236688066102507 0.411820095241797 no 2002 0.406449396903605 2852 2265554 SGTC_3024 9090631 49.47 µM -0.238360510859506 0.411269793899014 no 2003 0.40580074629111 2894 25236383 SGTC_450 aminopyrene 156 nM -0.238841390026162 0.411111597643212 no 2004 0.405614287123123 2926 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1 SGTC_1559 coumarin 343 70.1 µM -0.239360093849679 0.410940974301651 no 2005 0.405413185588779 2988 108770 A hepatotoxic, DNA x-linker. SGTC_3160 9100216 49.47 µM -0.240147611316928 0.410681959148774 no 2006 0.405107912716876 2793 17191039 SGTC_1262 0737-0114 49.6 µM -0.240697874070558 0.410501000375939 no 2007 0.404894643391508 2959 765919 SGTC_257 daunorubicin 18.5 µM -0.241682147464293 0.410177360906629 no 2008 0.40451323190258 2936 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_1751 st044839 27.194 µM -0.24226574842139 0.409985495631452 no 2009 0.404287126061202 2801 5291326 SGTC_2499 avocadenofuran 51.48 µM -0.243419561344442 0.409606230318191 no 2010 0.403840195848253 2819 6857792 A insecticide and lysyl oxidase inhibitor. SGTC_1214 0358-0031 63.7 µM -0.243594051338624 0.409548881751085 no 2011 0.403772617943064 3107 4301366 SGTC_56 0957-0365 83.25 µM -0.245041960025895 0.409073081162878 no 2012 0.403211971068409 2943 6752360 SGTC_2419 paclitaxel 166.5 µM -0.245456527572111 0.408936873807121 no 2013 0.403051482328485 2771 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase SGTC_297 0986-0032 24 µM -0.24594784689338 0.408775463674802 no 2014 0.402861302338364 2813 2847425 SGTC_690 glyoxal 20.3 µM -0.245980808067875 0.408764635695153 no 2015 0.402848544541801 2853 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins. SGTC_2511 berberine 10.47 µM -0.247275012424608 0.40833953550928 no 2016 0.402347697811286 2852 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2 0422-0095 29 µM -0.248389814247502 0.407973449121897 no 2017 0.401916406871608 2853 6790840 SGTC_306 1672-3436 11.6 µM -0.248421200534091 0.407963143435592 no 2018 0.401904265972028 2932 6797378 SGTC_2228 7354201 200 µM -0.249365864667118 0.407652992825099 no 2019 0.401538893652873 2869 753451 SGTC_1616 st002734 56.1 µM -0.249936167598368 0.407465779884906 no 2020 0.401318356468529 2858 4026101 SGTC_695 3505-6186 243 µM -0.251246583656866 0.407035690664391 no 2021 0.400811735387918 2968 1819379 SGTC_1798 st045719 60.953 µM -0.251604808373705 0.406918137880458 no 2022 0.400673270813626 2848 3980186 SGTC_300 r073-0011 5.04 µM -0.251793918081168 0.40685608420205 no 2023 0.400600179283719 2912 2735780 SGTC_1746 st038117 42 µM -0.251953394992282 0.40680375592446 no 2024 0.400538543632899 2949 2898218 SGTC_2641 levomentholum 100 µM -0.252601758694286 0.406591029068274 no 2025 0.40028798542261 2895 16666 SGTC_1131 3454-3128 32.3 µM -0.253051852944743 0.406443370233861 no 2026 0.400114071971454 3009 710982 SGTC_2762 leflunomide 42.06 µM -0.254039558196364 0.406119388296311 no 2027 0.399732498643713 2858 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1 SGTC_2297 7971671 152.32 µM -0.255850738834119 0.405525461392777 no 2028 0.399033046747946 3020 909016 SGTC_1837 st055472 66.5 µM -0.255973264785219 0.405485290212765 no 2029 0.398985740667252 3032 676091 SGTC_2131 toluylene red 5.2905 µM -0.256534221844107 0.405301388366058 no 2030 0.398769179546014 2898 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain. SGTC_3120 9124077 49.47 µM -0.258251747742183 0.40473845192427 no 2031 0.398106311542504 2852 18774327 YGL155W CDC43 SGTC_1878 temozolomide 1 mM -0.258940233517709 0.40451284904166 no 2032 0.397840677345513 2943 5394 DNA alkylating agent. SGTC_2822 7994718 71.43 µM -0.260250641116824 0.40408354270391 no 2033 0.397335221838559 2798 1018011 SGTC_981 1488-1094 54.9 µM -0.260407050613822 0.404032308651766 no 2034 0.397274902457625 2822 3449522 SGTC_3185 9108267 49.47 µM -0.262780030491627 0.403255209340263 no 2035 0.396360064060283 2949 4910486 SGTC_2856 9022925 19.48 µM -0.263232712333804 0.403107009160518 no 2036 0.396185609409542 3034 4944862 SGTC_2585 alliin 100 µM -0.263588722253973 0.402990467465531 no 2037 0.39604842481079 3074 87310 A garlic compound which reacts with lipids. SGTC_436 n,n-dimethylsphingosine 3.3 µM -0.26467422667813 0.402635175195469 no 2038 0.395630216872767 3218 5282309 SGTC_465 cgp-37157 41 µM -0.265427439086523 0.402388691374668 no 2039 0.395340100321346 2949 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange. SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -0.26720322086982 0.401807732179172 no 2040 0.394656348195062 2852 2333 A French combination drug. SGTC_672 1441-0018 53.7 µM -0.267891336476251 0.40158266867982 no 2041 0.394391481269614 2867 251141 SGTC_1728 st035614 33.7865 µM -0.268293142357919 0.401451264228075 no 2042 0.394236842198719 2973 15945546 SGTC_2160 5660466 132.927 µM -0.273628581326752 0.399707452685211 no 2043 0.392185033624075 2903 2859134 SGTC_2349 9023730 187.07 µM -0.273744932034581 0.399669447269986 no 2044 0.392140322683859 3038 4126287 SGTC_2152 5568786 200 µM -0.274314927230219 0.39948327474329 no 2045 0.391921307034572 2893 5399883 SGTC_3222 9128301 49.47 µM -0.275596204800549 0.399064865785578 no 2046 0.391429112475849 2919 4911358 SGTC_1710 st031758 61.5 µM -0.275705027227521 0.399029334497519 no 2047 0.391387317034342 3042 5394341 SGTC_2257 7960413 200 µM -0.27875848043312 0.398032702646476 no 2048 0.39021508982824 2887 2974689 YIL048W NEO1 SGTC_2483 5729050 27.16 µM -0.279323326537349 0.397848412391039 no 2049 0.389998353214715 3066 2865180 SGTC_2735 sertaconazole 140 nM -0.280827883021044 0.397357637607424 no 2050 0.389421208150395 2900 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C SGTC_2117 5521686 200 µM -0.282139548973474 0.396929914750447 no 2051 0.388918254415635 2862 803312 SGTC_2057 5236571 38.335 µM -0.284190976663546 0.396261210739376 no 2052 0.388132015046941 3077 54684039 YBR257W POP4 SGTC_1724 st037281 8.293 µM -0.285799271899186 0.395737167887176 no 2053 0.387515932909602 2889 574124 YDL195W SEC31 SGTC_1152 3909-8331 15.9 µM -0.286521387877349 0.395501936678025 no 2054 0.387239407326845 2926 16001939 SGTC_2394 5221648 200 µM -0.286532265550589 0.395498393537711 no 2055 0.387235242290435 3036 788586 SGTC_2035 5154463 94.595 µM -0.286989629579596 0.395349426030697 no 2056 0.387060130394584 3060 2769623 SGTC_260 nsc-65238 3.989 µM -0.287341887883747 0.395234702809899 no 2057 0.386925276207282 3033 3246252 SGTC_685 1278-0033 54.9 µM -0.288192772511968 0.394957624815177 no 2058 0.386599590454374 3058 3590572 SGTC_3132 9126706 49.47 µM -0.28880803126868 0.394757307979772 no 2059 0.38636414291325 3125 850858 SGTC_2620 irigenin 100 µM -0.289881489875373 0.394407876416368 no 2060 0.385953451429448 3097 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro. SGTC_1115 galangin 695.678 nM -0.290636156823238 0.394162268550781 no 2061 0.385664802008317 3063 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity. SGTC_2464 5717415 7.67 µM -0.292363004202787 0.393600421081012 no 2062 0.385004545735724 2939 5285744 SGTC_483 fpl-64176 144 µM -0.292502754987129 0.39355496140363 no 2063 0.384951126884866 2922 3423 SGTC_521 r062-0005 13.8 µM -0.292605038002373 0.393521690575184 no 2064 0.384912031234948 2898 2832033 SGTC_1757 st041620 31.8375 µM -0.293290164687668 0.393298851221281 no 2065 0.384650185360933 2993 5289815 SGTC_1007 4101-0031 70 µM -0.294139221237944 0.393022741727536 no 2066 0.384325760787069 3080 1146276 SGTC_3299 9121982 43.1275 µM -0.296625707025519 0.392214457394345 no 2067 0.383376141177045 2954 17594604 YPL160W CDC60 SGTC_3298 9116858 71.43 µM -0.29697022521612 0.392102501120331 no 2068 0.383244620531728 3076 2506942 SGTC_968 1309-0633 340 µM -0.298024518595092 0.391759948442829 no 2069 0.382842225158822 3028 3761976 SGTC_1392 3455-1037 33.9 µM -0.298547345390446 0.391590106792294 no 2070 0.382642723122823 3083 981132 SGTC_3190 9110366 49.47 µM -0.298831167755498 0.391497915006457 no 2071 0.382534434251047 3039 17123768 SGTC_2072 5231554 129 µM -0.299078599893611 0.391417548543705 no 2072 0.382440037108018 3040 789545 SGTC_590 k048-0076 22.4 µM -0.299772846297131 0.391192080653399 no 2073 0.382175214416753 3049 6832814 SGTC_101 0490-5701 117.494 µM -0.300118122977993 0.39107996000439 no 2074 0.382043527944838 2920 4661669 SGTC_85 0868-0259 160.055 µM -0.30021311615942 0.391049114744157 no 2075 0.382007300503436 2986 83173 SGTC_2664 lyso-paf C-16 73.48 µM -0.300452667991114 0.390971332851293 no 2076 0.381915947482582 2937 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling. SGTC_828 2074-0507 139 µM -0.300971198746381 0.39080298212652 no 2077 0.381718228456056 3082 X828 SGTC_169 k015-0017 16.025 µM -0.303048712714094 0.390128683836221 no 2078 0.38092636929685 3167 1840002 SGTC_3309 9129340 25.759 µM -0.303510879387925 0.389978723352705 no 2079 0.380750278855693 2981 17158987 SGTC_2286 7945697 125 µM -0.304109809357389 0.389784411269681 no 2080 0.380522116886163 2991 1245733 SGTC_882 0843-0131 351 µM -0.306526271785277 0.389000713600142 no 2081 0.379601989948511 2946 5425421 SGTC_358 0075-0058 9.45 µM -0.308366696662072 0.388404136817213 no 2082 0.378901660122617 2967 1069125 SGTC_1951 sophoraflavanone G 9.2 µM -0.311036601423258 0.387539150887033 no 2083 0.377886398389527 2963 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity. SGTC_592 k241-0073 46.5 µM -0.311755159685591 0.387306450127091 no 2084 0.37761330207287 3077 4230158 SGTC_1302 1159-0335 255 µM -0.312209994119087 0.387159175657939 no 2085 0.377440468631314 2966 649284 SGTC_1407 3909-7909 12.3 µM -0.313136707922459 0.38685915788243 no 2086 0.377088400783688 2979 4411780 SGTC_1446 4239-0190 62 µM -0.315201236073875 0.386191023127113 no 2087 0.376304433557278 2984 1340085 SGTC_729 4092-0585 94.1 µM -0.315268347644904 0.386169309736324 no 2088 0.376278957694318 2940 2169061 SGTC_1743 st037606 46.3785 µM -0.316217326930981 0.385862313572829 no 2089 0.375918778512597 2976 590142 YLR208W | YDL195W SEC13 | SEC31 SGTC_3035 9091303 49.47 µM -0.318406407720452 0.385154415667349 no 2090 0.375088339177188 2969 25237002 SGTC_2014 4013930 200 µM -0.320872235599238 0.384357482397924 no 2091 0.374153607534512 3030 64556 SGTC_773 4358-1457 44.6 µM -0.321321999504349 0.384212175356602 no 2092 0.373983193227951 3143 1186886 SGTC_863 0466-0191 129 µM -0.322020529315732 0.383986530776679 no 2093 0.373718571039611 3098 765160 YPR165W RHO1 SGTC_2189 6047310 154.431 µM -0.322927935753436 0.383693471956995 no 2094 0.373374909566651 2939 711535 SGTC_2657 nystatin 74.44 µM -0.32524251321999 0.382946250349185 no 2095 0.37249876765215 3034 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. SGTC_3321 9137793 26.8275 µM -0.325621425749262 0.382823966342414 no 2096 0.372355399779491 3025 4904192 SGTC_671 0560-0003 407 µM -0.327062294766519 0.382359070681352 no 2097 0.371810384636611 3015 3238678 SGTC_1936 st074407 74.3 µM -0.329411318064559 0.381601523214091 no 2098 0.370922407084072 2988 809813 SGTC_1771 st048882 4.1505 µM -0.330266499258009 0.381325844242032 no 2099 0.370599301887735 2980 4580403 SGTC_2987 9018338 71.43 µM -0.330476012290237 0.38125831412044 no 2100 0.370520157424932 3091 5055682 SGTC_383 2324-0395 7.37 µM -0.331125251081225 0.381049074810518 no 2101 0.37027493945014 3122 3146421 SGTC_3226 9131256 49.47 µM -0.332812147269934 0.380505577765686 no 2102 0.369638044137758 2995 17178073 SGTC_419 nsc-638432 893 µM -0.333713237605279 0.380215354168915 no 2103 0.369297979762249 3058 368090 SGTC_1321 1326-2144 215 µM -0.333975080344168 0.380131032373326 no 2104 0.369199181541762 3099 3513030 SGTC_1043 0916-0009 19.3 µM -0.337622791842801 0.378956945963088 no 2105 0.367823732166026 3178 3101130 SGTC_1343 1487-0095 224 µM -0.337744769056109 0.378917704463355 no 2106 0.367777767151673 3140 4560101 YGL055W OLE1 SGTC_3092 9117248 49.47 µM -0.33821763358697 0.378765590199682 no 2107 0.367599594193137 3051 17141857 SGTC_808 0711-0032 135 µM -0.338690842504038 0.3786133839498 no 2108 0.367421319995888 3116 4252555 SGTC_2165 5727197 32.143 µM -0.339048612443174 0.378498320802935 no 2109 0.36728655462571 3362 1361712 SGTC_501 nsc-95397 161 µM -0.340968979185748 0.377880891905845 no 2110 0.366563467443525 3172 262093 SGTC_2492 derrusnin 100 µM -0.34188307757431 0.377587103967391 no 2111 0.366219442631965 2941 1715307 Part of coumarin class of compounds. SGTC_604 1000-0114 314 µM -0.343534631349179 0.377056480160922 no 2112 0.365598146089186 3155 1572745 SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM -0.344184338970447 0.376847800689826 no 2113 0.365353829659822 2957 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding. SGTC_880 0833-0487 87.2 µM -0.345164421215153 0.376533076332695 no 2114 0.364985382352636 2999 76075 SGTC_3292 9120825 59.784 µM -0.345861770207017 0.376309193326768 no 2115 0.364723300258669 3181 24824900 SGTC_2818 7996756 12.99 µM -0.346236235750796 0.376188988807265 no 2116 0.364582592332238 2938 2241621 SGTC_615 k087-0205 167 µM -0.346457739044191 0.376117891263339 no 2117 0.36449936957748 3024 9642773 SGTC_3014 9081533 49.47 µM -0.35277500813068 0.374091969285833 no 2118 0.362128560662896 3157 21367265 SGTC_3199 9111318 49.47 µM -0.353484382344227 0.373864691761825 no 2119 0.361862667562544 3140 8548020 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.355128086841103 0.37333823131701 no 2120 0.3612468179936 3148 1377 SGTC_2705 st078069 42.8 µM -0.356217684882972 0.372989375265627 no 2121 0.360838774422342 3100 1530061 SGTC_569 4130-2812 160 µM -0.356409588157463 0.372927944467525 no 2122 0.360766924952913 3073 743552 SGTC_1516 st013856 110 µM -0.358848877866408 0.372147377338461 no 2123 0.359854072656283 3130 5281404 A mutagen and neurotoxin. SGTC_2253 7938677 135.83 µM -0.360822023599559 0.371516359179653 no 2124 0.359116248949174 3215 2301972 SGTC_2721 ifenprodil 61.44 µM -0.360913693293238 0.371487051302342 no 2125 0.35908198339866 3176 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor. SGTC_2221 6807166 181.081 µM -0.36165216021305 0.371250981946098 no 2126 0.358805990516069 3098 674925 SGTC_172 1112-0046 2.638 µM -0.363325450705534 0.370716252257379 no 2127 0.358180891776851 3043 2802135 YIL048W NEO1 SGTC_1059 3448-6867 171 µM -0.363456664790143 0.370674331008416 no 2128 0.358131889578632 3084 3934407 SGTC_1026 k007-1105 30.6 µM -0.36350635161892 0.370658457092575 no 2129 0.35811333452942 3027 7066794 SGTC_3039 9090270 49.47 µM -0.363837642409064 0.370552622155165 no 2130 0.357989625866097 3189 17173750 SGTC_2630 antimycin a 100 µM -0.364579563480675 0.37031564184341 no 2131 0.357712636155762 2994 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain. SGTC_3262 9137218 49.47 µM -0.364810520968505 0.370241880724511 no 2132 0.35762642549143 2955 17650664 SGTC_1260 0700-1617 7.75 µM -0.365088386270394 0.37015314493478 no 2133 0.357522714937591 3152 2853078 SGTC_373 0844-0104 25.9 µM -0.365094841762347 0.370151083467036 no 2134 0.357520305612272 3181 5375804 SGTC_1404 3909-7820 48.3 µM -0.365185284109322 0.370122202407274 no 2135 0.357486551224011 3150 23741373 SGTC_1885 st057546 99.9 µM -0.365596101656669 0.369991024782629 no 2136 0.357333242226907 3220 702008 SGTC_1615 st002656 86.5 µM -0.365666292630071 0.369968613705185 no 2137 0.357307050643917 3090 1584458 SGTC_2880 9042983 58.44 µM -0.36810209655731 0.369191166782709 no 2138 0.35639855382834 3171 6464714 SGTC_2756 carbadox 75.1 µM -0.369642029032944 0.368699935021621 no 2139 0.355824615510961 3069 2553 A substituted quinoxaline antibiotic. YLR208W SEC13 SGTC_464 bw-b 70c 158 µM -0.370403936442628 0.368456969124072 no 2140 0.355540770605703 3162 5353454 SGTC_716 1683-5115 658 µM -0.37071501684228 0.368357783300484 no 2141 0.355424902132165 3074 723597 SGTC_461 N-acetylfarnesylcysteine 136 µM -0.372214942057134 0.367879665794449 no 2142 0.354866410966959 3151 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ). SGTC_1971 st069429 63.5 µM -0.372259971131133 0.367865315446669 no 2143 0.354849649385082 3175 1246522 YGL099W LSG1 SGTC_2829 7992743 58.44 µM -0.375567996981148 0.366811584003565 no 2144 0.353619043260311 3206 16462845 SGTC_2375 9072683 200 µM -0.376909762446088 0.366384466331089 no 2145 0.35312033309696 3235 16798029 SGTC_278 4092-0821 23.9 µM -0.377703833903666 0.366131771324908 no 2146 0.352825309693063 3144 877900 SGTC_2982 9019404 25.97 µM -0.377827815894638 0.36609232213989 no 2147 0.352779254327222 3060 22333232 SGTC_965 1291-5240 308 µM -0.380151778548709 0.365353134887958 no 2148 0.351916376003398 3203 2834598 SGTC_1344 1488-0097 29.1 µM -0.383628260779147 0.364248297419517 no 2149 0.35062699537209 3183 747966 SGTC_1005 4092-0690 4.4 µM -0.384233532080021 0.36405605515811 no 2150 0.350402683633188 3103 1529343 SGTC_964 1287-0107 19.4 µM -0.384681646888515 0.363913749934083 no 2151 0.350236647221943 3234 51516812 YPR165W RHO1 SGTC_2799 7812892 81.82 µM -0.385076278067613 0.363788444735959 no 2152 0.350090451372359 3229 20205235 SGTC_2518 prenyletin 46.28 µM -0.385395176121482 0.363687197326308 no 2153 0.349972327994674 3167 3873459 A coumarin with calcium channel inhibitory activity. SGTC_181 1447-1644 8.07 µM -0.386546618633225 0.363321703435176 no 2154 0.349545941821125 3186 534600 SGTC_477 mead ethanolamide 10 µM -0.389980520700574 0.362232445129692 no 2155 0.348275475527639 3119 16061185 SGTC_2715 st079500 56.4 µM -0.391187316085361 0.361849905227045 no 2156 0.34782939156129 3053 28246688 SGTC_491 tetrandrine 80.3 µM -0.391586051030767 0.361723541263297 no 2157 0.347682048061803 3175 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_951 1171-0579 82.7 µM -0.391709618578921 0.361684384260781 no 2158 0.347636391131556 3079 1616050 YPR165W | YDR526C RHO1 | YDR526C SGTC_2650 prasterone 100 µM -0.392925468263917 0.361299174074285 no 2159 0.347187265196306 3157 16759247 A steroid and weak partial agonist of the androgen receptor. SGTC_35 0133-0054 64.071 µM -0.393298656611373 0.361180967281613 no 2160 0.347049455163873 3125 99677 SGTC_1145 3546-0597 10.2 µM -0.395763813087893 0.360400466459113 no 2161 0.346139637355265 3133 875334 SGTC_3254 9136651 49.47 µM -0.39718776654866 0.359949888816665 no 2162 0.345614501354024 3122 16454030 SGTC_406 estrone 100 µM -0.397973378214146 0.359701383125189 no 2163 0.345324904761166 3274 5870 A steroid. SGTC_104 0074-0074 590.992 µM -0.398682200980104 0.359477218287552 no 2164 0.345063692208745 3076 3943124 SGTC_3118 9124250 49.47 µM -0.399987024175761 0.359064695088144 no 2165 0.34458303701069 3126 1504786 SGTC_3202 9113761 49.47 µM -0.400282356113101 0.358971347921579 no 2166 0.344474280937515 3236 4798415 SGTC_1383 3049-0032 20.7 µM -0.40171740523161 0.358517884126915 no 2167 0.343946006826222 3247 712864 SGTC_3005 9076496 71.4286 µM -0.401800442937788 0.358491650987575 no 2168 0.343915448073605 3225 21368410 SGTC_2374 9071832 200 µM -0.404356851699443 0.357684361685202 no 2169 0.342975162373012 3213 17381698 SGTC_2787 5284540 71.43 µM -0.407149086795042 0.356803327699077 no 2170 0.341949246401746 3147 736958 SGTC_549 1661-1316 519 µM -0.408473728211326 0.35638563022204 no 2171 0.341462957251482 3262 2857282 SGTC_1959 st077091 55.8 µM -0.409051774289159 0.356203409640736 no 2172 0.34125083313749 3052 821356 YKL052C ASK1 SGTC_2763 lisinopril 49.32 µM -0.40993320544088 0.355925614561597 no 2173 0.340927473127205 3195 5362119 A lysine-analog of enalapril and an ACE inhibitor. SGTC_1373 2887-0003 58.5 µM -0.412019415819681 0.355268421777382 no 2174 0.340162596128159 3167 776948 SGTC_2206 7254556 146.969 µM -0.412473092954969 0.35512556242229 no 2175 0.339996349273196 3175 4398905 SGTC_1203 3992-3522 103 µM -0.414034670863685 0.35463398961306 no 2176 0.339424357810407 3425 5322312 SGTC_1219 1469-0211 33.1 µM -0.415791773618961 0.354081156421666 no 2177 0.338781189505696 3234 6822282 SGTC_1929 genistein trimethyl ether 50.5 µM -0.415958729019163 0.354028643604458 no 2178 0.338720101712292 3316 136420 SGTC_1690 st023502 41.2 µM -0.417174104255217 0.353646452914683 no 2179 0.338275532491322 3230 24207482 SGTC_1817 st052116 64.4 µM -0.417375575312688 0.353583111936966 no 2180 0.338201858631323 3261 4361398 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM -0.418139827893334 0.353342873571571 no 2181 0.337922443378816 3307 23847180 SGTC_1368 1852-0141 284 µM -0.418288647883326 0.35329609966393 no 2182 0.337868044293136 3237 2838987 SGTC_3215 9129942 49.47 µM -0.418451677470876 0.353244862243655 no 2183 0.337808454972598 3258 17682944 SGTC_2615 purpurogallin-4-carboxylic acid 100 µM -0.418972907270725 0.353081066454174 no 2184 0.337617966346999 3154 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase. SGTC_1974 st069448 26.9 µM -0.4192161849415 0.353004626075875 no 2185 0.337529072332254 3264 6323587 YNR016C ACC1 SGTC_1464 k208-0027 110 µM -0.419226437278491 0.353001404815038 no 2186 0.337525326312447 3319 X1464 SGTC_1933 st074711 15.9 µM -0.420004547332226 0.352756955173196 no 2187 0.337241065879113 3190 17250958 SGTC_2435 5706476 10.6 µM -0.420361970108028 0.352644688247878 no 2188 0.337110522731651 3288 5725375 SGTC_2839 9003951 25.97 µM -0.420488069489699 0.352605083341726 no 2189 0.337064471559921 3249 2990634 SGTC_1608 st001473 40.5 µM -0.421968907650646 0.35214010589217 no 2190 0.33652385611507 3152 7292267 SGTC_2636 apigenin dimethyl ether 100 µM -0.422843108762012 0.351865713807325 no 2191 0.336204866522694 3287 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. SGTC_3172 9105863 49.47 µM -0.424584194857442 0.351319455913069 no 2192 0.335569908351837 3179 2348785 SGTC_2350 9023895 38.85 µM -0.426311804177152 0.350777729697518 no 2193 0.334940328811385 3286 2997209 SGTC_2584 androsterone 48.74 µM -0.426784429946655 0.350629581280366 no 2194 0.334768174075186 3264 2754130 A steroid. SGTC_2884 9058502 51.95 µM -0.429483569627136 0.349783949704182 no 2195 0.333785674194453 3252 6471554 SGTC_356 1634-0012 32.5 µM -0.429528659570409 0.349769829485716 no 2196 0.333769270887634 3276 735457 SGTC_3034 9090421 49.47 µM -0.429556096731371 0.349761237456241 no 2197 0.333759289656194 3220 17173761 SGTC_2101 5377231 179.231 µM -0.430472328625392 0.349474360893971 no 2198 0.333426045701387 3255 2844213 SGTC_854 0422-0053 192 µM -0.432018439873193 0.348990461080096 no 2199 0.332864005556217 3241 3596728 SGTC_1841 st054148 70 µM -0.433620430403451 0.348489331169818 no 2200 0.332282048147247 3226 675442 SGTC_911 3456-4043 236 µM -0.433621285624864 0.348489063712515 no 2201 0.332281737577551 3226 914281 SGTC_2594 a-mangostin 100 µM -0.434296737403305 0.348277850121495 no 2202 0.332036486373501 3292 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis. SGTC_250 brefeldin a 552.239 µM -0.435042809430121 0.348044608278002 no 2203 0.331765677126276 3165 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.  SGTC_313 3474-0040 5.03 µM -0.437800959325677 0.34718283728117 no 2204 0.330765287743613 3134 1043375 YIL048W NEO1 SGTC_316 k060-0003 58.6 µM -0.437854932481648 0.347165981484258 no 2205 0.330745723538577 3274 6152314 SGTC_1596 piperlongumine 63 µM -0.437876165680515 0.347159350446865 no 2206 0.330738027049289 3307 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_536 3852-0578 10.6 µM -0.439528172698229 0.346643579293929 no 2207 0.330139436516069 3307 2869208 SGTC_638 3970-0837 4.09 µM -0.43975520371049 0.346572720396231 no 2208 0.33005720770962 3187 4118451 YLR208W SEC13 SGTC_2923 7992654 58.14 µM -0.441012468060141 0.346180411478161 no 2209 0.329601985377894 3190 2985126 SGTC_184 1494-0393 24.714 µM -0.441469129899648 0.34603795839759 no 2210 0.329436702585835 3122 3090647 SGTC_1525 8-methoxypsoralen 92.5 µM -0.441918260721555 0.345897875824719 no 2211 0.329274178045483 3383 4114 Related to psoralen; DNA damaging agent. SGTC_2468 5987765 72.9 µM -0.442011029638203 0.345868944101821 no 2212 0.329240612277873 3197 26772094 SGTC_1637 st007924 17.4 µM -0.442708002221137 0.34565160894645 no 2213 0.328988476799909 3171 683336 SGTC_1151 3909-8316 15.3 µM -0.443282237668499 0.345472584805035 no 2214 0.328780800915392 3299 800431 SGTC_1995 st072814 61.1 µM -0.443477467120836 0.345411727771913 no 2215 0.328710206985337 3183 5769371 SGTC_1952 st077036 64.1 µM -0.446025450369145 0.344617835944702 no 2216 0.327789431013685 3250 2937007 SGTC_567 1080-0542 68.4 µM -0.44789155992138 0.344036833568141 no 2217 0.327115729949639 3279 5950415 SGTC_2893 9048488 25.97 µM -0.449421021064171 0.343560919056945 no 2218 0.326563984987972 3217 6467338 SGTC_1070 indatraline 8.81 µM -0.450345225341845 0.343273459286831 no 2219 0.326230766913785 3220 10314472 A monamine transport inhibitor. YGL099W LSG1 SGTC_2484 5809818 12.04 µM -0.451012681526447 0.343065913494294 no 2220 0.325990204532022 3210 2870548 SGTC_2346 9031566 143.75 µM -0.452434651062282 0.342623909356185 no 2221 0.325477944459068 3229 4771086 SGTC_1225 1216-0074 20.6 µM -0.454456588924355 0.341995782414267 no 2222 0.32475011516501 3206 4241466 SGTC_3017 9080681 49.47 µM -0.45510830338658 0.34179341651888 no 2223 0.324515662329277 3267 16451914 SGTC_1901 st060216 58.6 µM -0.456008629450407 0.341513928234228 no 2224 0.324191886408909 3179 688792 SGTC_2789 5281112 71.43 µM -0.456633888744017 0.341319880056525 no 2225 0.323967108387968 3215 765948 SGTC_234 nsc-17383 10.7 µM -0.457581093914407 0.34102599643234 no 2226 0.323626714469525 3339 408974 SGTC_1660 st012960 28.1 µM -0.458794352206171 0.340649706983681 no 2227 0.32319092544124 3275 24207266 SGTC_2477 5967686 25.23 µM -0.458845271082378 0.340633918067591 no 2228 0.323172641240113 3152 776118 SGTC_886 0866-0150 153 µM -0.459998659010566 0.34027635059136 no 2229 0.322758591518584 3357 271463 SGTC_689 0833-0039 98 µM -0.461069502937634 0.33994450149701 no 2230 0.322374370505184 3265 5374726 SGTC_2954 9074818 52.69 µM -0.461343586019368 0.339859584459076 no 2231 0.322276059398891 3340 16648742 SGTC_869 0564-0080 44.1 µM -0.462960723350117 0.339358724852096 no 2232 0.321696260185742 3247 6843321 SGTC_1071 trifluoperazine 6.31 µM -0.465740189420552 0.338498532034586 no 2233 0.320700740728627 3338 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. SGTC_3257 9139206 32.98 µM -0.469621512880631 0.337298744358529 no 2234 0.319312725990105 3311 4910041 SGTC_2687 chenodiol 100 µM -0.470110158751912 0.337147811910845 no 2235 0.319138158305344 3322 5702181 A cholesterol synthesis inhibitor. SGTC_753 1322-0200 289 µM -0.476791057754139 0.335086860287075 no 2236 0.316755457004664 3371 5403907 SGTC_1097 itavastatin 7.23 µM -0.476955505308382 0.335036193059797 no 2237 0.316696903022382 3271 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49 SGTC_1436 4092-1007 8.32 µM -0.478021673939816 0.334707773293922 no 2238 0.316317389382968 3237 2881121 SGTC_925 2064-1272 59.6 µM -0.478662460450097 0.334510447910661 no 2239 0.316089387877666 3244 6815817 SGTC_1128 3448-9350 235 µM -0.478707707238568 0.334496516229726 no 2240 0.316073291029985 3262 619386 SGTC_770 0389-1121 67.2 µM -0.479147533934247 0.334361103574347 no 2241 0.315916837911365 3408 6753108 SGTC_2703 st077852 53.4 µM -0.48027963023894 0.334012655978931 no 2242 0.315514285543366 3336 6281836 SGTC_2872 9044037 25.97 µM -0.482341294639796 0.333378464490587 no 2243 0.314781758435719 3273 6465195 SGTC_846 0335-0850 148 µM -0.48238749801071 0.333364257253273 no 2244 0.314765350312668 3305 6819598 SGTC_110 0850-0284 111.64 µM -0.482790477343999 0.33324035385502 no 2245 0.314622256467552 3162 3906265 SGTC_1713 st033146 12.748 µM -0.483160584612223 0.333126573607218 no 2246 0.314490859679935 3397 674619 SGTC_3042 9091578 49.47 µM -0.483874011154446 0.332907291755275 no 2247 0.314237642778504 3339 25236497 SGTC_524 r073-0010 27.8 µM -0.484013350503321 0.332864470480155 no 2248 0.314188197180264 3207 2772106 SGTC_2608 thymoquinone 42.66 µM -0.485123682241913 0.332523325194423 no 2249 0.313794306969647 3342 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC). SGTC_2803 7707263 71.43 µM -0.486439459411933 0.332119237099309 no 2250 0.313327809629635 3224 2199229 SGTC_1720 st037298 9.481 µM -0.488560732009846 0.331468184478098 no 2251 0.31257635966839 3326 597396 SGTC_789 1309-1135 70.6 µM -0.489490370647369 0.331183023716771 no 2252 0.312247285094544 3344 3092424 SGTC_2649 anisomycin 9.56 µM -0.490378528365524 0.33091067838058 no 2253 0.311933033821924 3336 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.491068373135404 0.330699205591094 no 2254 0.311689044783382 3350 688662 SGTC_1320 1313-0481 95.3 µM -0.492668639204481 0.330208850121189 no 2255 0.311123370037107 3419 6813365 YLR208W SEC13 SGTC_985 1493-0307 8.71 µM -0.495238382552454 0.3294220363382 no 2256 0.310215929961449 3408 3278274 SGTC_353 1988-1175 58.3 µM -0.49853795530662 0.328412867453865 no 2257 0.309052461972561 3209 2788357 SGTC_98 0074-0023 107.663 µM -0.501237724201 0.327588077356133 no 2258 0.308101913871721 3334 3563821 SGTC_328 k915-0120 63.5 µM -0.501295766359546 0.32757035446362 no 2259 0.308081492195232 3352 6624543 SGTC_2904 7225135 42.03 µM -0.501865157980206 0.327396514090744 no 2260 0.307881187749996 3397 4446116 SGTC_1899 st063254 59.6 µM -0.502778839708824 0.327117637075383 no 2261 0.307559886216724 3239 3093813 SGTC_1170 0310-0127 64.8 µM -0.502912504739421 0.327076847471872 no 2262 0.307512894493723 3314 774975 SGTC_2612 dictamnine 15.46 µM -0.503994279685184 0.326746805970884 no 2263 0.30713269837909 3315 68085 A quinoline derivative and established mutagen. YOR116C RPO31 SGTC_835 0312-0010 67.2 µM -0.505299913617852 0.326348647250839 no 2264 0.306674101740011 3277 1626196 SGTC_635 k038-0028 24.7 µM -0.506065513346264 0.326115266266583 no 2265 0.306405329741596 3315 4035102 SGTC_2051 5263410 176 µM -0.50620214049432 0.326073624795631 no 2266 0.306357376259908 3424 227584 SGTC_2334 9017922 200 µM -0.506884184547971 0.325865782611994 no 2267 0.306118041625839 3351 3163164 SGTC_1018 4259-0013 28.1 µM -0.50883989623189 0.325270110444357 no 2268 0.305432225974786 3374 6801262 SGTC_986 1493-0483 84 µM -0.513815254463931 0.323756726122812 no 2269 0.303690580859956 3390 40079 SGTC_1114 scopoletin 1.73284 µM -0.513821714473053 0.323754763029479 no 2270 0.303688322390212 3419 5280460 A coumarin with genotoxic properties. SGTC_1501 4491-0275 38.4 µM -0.515619606263145 0.323208603252428 no 2271 0.303060056971512 3387 5104718 SGTC_1412 3909-8563 178 µM -0.516102805507886 0.32306188288768 no 2272 0.302891304301593 3426 23767530 SGTC_222 nsc-310342 10.666 µM -0.516739969574032 0.322868454169278 no 2273 0.302668845235355 3375 432556 SGTC_525 k781-2675 26.7 µM -0.516909925924509 0.322816867324926 no 2274 0.302609519150145 3414 3651118 YDL195W SEC31 SGTC_2277 7947813 106.88 µM -0.517374811655158 0.322675777996609 no 2275 0.302447269697792 3472 1246798 SGTC_3004 9076122 71.4286 µM -0.517946126669226 0.322502423141285 no 2276 0.302247928877995 3410 44782551 SGTC_2008 4012253 172 µM -0.521290521094554 0.321488404224222 no 2277 0.301082201601681 3320 603940 SGTC_1579 chlormadinone acetate 49.4 µM -0.521565995608781 0.321404939606082 no 2278 0.300986272166867 3424 45114258 A steroidal progestin. SGTC_108 0509-0257 621.132 µM -0.522926256086488 0.320992933480552 no 2279 0.300512786145216 3336 536624 SGTC_90 0870-0863 4.608 µM -0.524013611179168 0.320663745435853 no 2280 0.300134536448336 3338 1738164 SGTC_2212 7123476 200 µM -0.524810956223804 0.32042244519032 no 2281 0.299857307181952 3361 1085715 SGTC_2936 9038235 15.59 µM -0.527729673130487 0.319539802950681 no 2282 0.298843487468189 3360 4749415 SGTC_1687 st020778 55.3625 µM -0.527739663927411 0.319536783408786 no 2283 0.298840019829434 3382 4259299 SGTC_3110 9122132 49.47 µM -0.528541697765426 0.319294421895763 no 2284 0.298561706947027 3490 918317 SGTC_3208 9114115 49.47 µM -0.529827909919805 0.318905910806944 no 2285 0.298115626191269 3355 650895 SGTC_632 0781-2353 4.65 µM -0.530601890266234 0.318672219424463 no 2286 0.297847342757656 3413 6811515 YHR007C ERG11 SGTC_459 nigericin 15.3 µM -0.530659732258968 0.318654757824577 no 2287 0.297827297512676 3450 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification. SGTC_205 1486-1330 71.903 µM -0.531873082207997 0.318288559176842 no 2288 0.297406950836125 3390 4118834 SGTC_2737 bleomycin 30.5 nM -0.532185845949889 0.318194193357341 no 2289 0.297298642526833 3420 16211318 Bleomycin acts by induction of DNA strand breaks. SGTC_623 k072-0108 16.9 µM -0.532911099199639 0.317975418270426 no 2290 0.297047560818558 3383 5382803 SGTC_1898 st060199 18.6 µM -0.533316286953866 0.317853219665777 no 2291 0.296907327596645 3394 688866 SGTC_2746 daunorubicin 9.88 µM -0.53454577805951 0.317482544864637 no 2292 0.296481993114784 3329 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_2330 7979373 200 µM -0.536189976845404 0.316987127287189 no 2293 0.295913630007059 3331 1863007 SGTC_1270 0831-1170 17.3 µM -0.537248555527638 0.316668337798145 no 2294 0.295547967765618 3429 6764716 SGTC_2155 5570423 76 µM -0.537326791855123 0.316644782436493 no 2295 0.295520951029506 3320 797402 SGTC_259 usnic acid 108.925 µM -0.537893809685233 0.316474087165455 no 2296 0.295325181168822 3490 5646 An anti-infective, antifungal and antitrichomonal agent. SGTC_2814 7977482 42.97 µM -0.538171658517933 0.316390457710099 no 2297 0.295229272243025 3448 6456762 SGTC_1610 st001799 48.1 µM -0.53877750670656 0.316208136601032 no 2298 0.295020192973779 3295 621897 SGTC_1578 josamycin 24.2 µM -0.541433039935923 0.315409520453763 no 2299 0.29410456956098 3340 5282165 A P450 substrate. SGTC_322 k048-0136 19.3 µM -0.542721741500113 0.315022270929996 no 2300 0.293660701250583 3429 6823282 SGTC_1335 1486-0900 202 µM -0.545088320832602 0.314311653088246 no 2301 0.29284638742003 3430 X1335 SGTC_1994 st072947 40.9 µM -0.548532017362651 0.313278835651323 no 2302 0.291663325521441 3460 5286565 YDL195W SEC31 SGTC_1996 st072960 66.8 µM -0.549300172648366 0.313048653350013 no 2303 0.291399734453386 3478 1719405 SGTC_1169 aniline yellow 25.8 µM -0.550088029376313 0.312812643062372 no 2304 0.291129498385527 3383 6051 A DNA damaging agent. SGTC_518 1021-0119 62.6 µM -0.55015291235392 0.312793210141188 no 2305 0.291107248641519 3334 1097762 SGTC_3319 9138450 16.7555 µM -0.550579787188425 0.312665371013619 no 2306 0.290960884045084 3347 2029690 SGTC_2311 7694451 200 µM -0.551381397616611 0.312425368149533 no 2307 0.290686125036509 3352 2163142 SGTC_1992 st073643 23.3 µM -0.55306112751304 0.311922713615878 no 2308 0.290110776787908 3422 3161292 SGTC_1141 3253-0389 52.6 µM -0.553433252836765 0.31181140347571 no 2309 0.289983387083679 3440 5402031 SGTC_2263 7948595 193.29 µM -0.558401423949801 0.310326973789438 no 2310 0.28828515034592 3428 2971371 SGTC_3150 9097574 49.47 µM -0.55919631048557 0.310089756888191 no 2311 0.288013875433448 3464 17217476 SGTC_472 calcifediol 10 µM -0.559237393296856 0.310077498747719 no 2312 0.287999858171867 3427 5283731 A vitamin D metabolite. SGTC_1508 1080-0625 72.9 µM -0.559725651646485 0.309931830153372 no 2313 0.287833291386265 3412 767111 SGTC_3287 9117173 37.0625 µM -0.559967535866448 0.309859676672398 no 2314 0.287750790705697 3380 2789709 SGTC_547 1120-0019 610 nM -0.562256787017735 0.309177161537078 no 2315 0.28697053794199 3436 3676939 SGTC_1030 k029-0042 36.7 µM -0.56293977670357 0.308973662988924 no 2316 0.28673794665078 3408 6080581 SGTC_1382 3002-2117 298 µM -0.563302742322581 0.308865540289872 no 2317 0.286614375537931 3520 1497314 SGTC_1563 conessine 56.1 µM -0.564790286661619 0.308422593439451 no 2318 0.286108207293242 3504 441082 An anti-amoebic, histamine inhibitor. SGTC_1078 idebenone 36.1 µM -0.565446827237426 0.308227183627267 no 2319 0.28588494071828 3453 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen. SGTC_1711 st032263 62.8 µM -0.566075969317954 0.308039979561169 no 2320 0.285671069170651 3415 3958979 SGTC_2363 9053361 176 µM -0.566078162322813 0.308039327109981 no 2321 0.285670323810289 3531 6469797 YMR079W SEC14 SGTC_1792 st045773 43.6 µM -0.566586628460009 0.307888067340109 no 2322 0.285497530889444 3429 2919270 SGTC_2488 5268135 45.7 µM -0.56783310436096 0.307517400703142 no 2323 0.285074149468967 3444 1270356 YLR208W SEC13 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM -0.568787053959556 0.30723385578578 no 2324 0.284750330666898 3581 16725076 SGTC_2502 avocadyne acetate 18.59 µM -0.569299553503703 0.307081571773482 no 2325 0.284576434889344 3432 3952079 SGTC_1300 1094-0077 113 µM -0.570813831462615 0.306631813978346 no 2326 0.28406292304473 3427 5532636 SGTC_1513 0337-0559 19 µM -0.573498009027557 0.305835298097398 no 2327 0.283153773388384 3367 775073 SGTC_1280 0880-0253 10.1 µM -0.573529663429131 0.305825910283702 no 2328 0.283143060156354 3421 6836607 SGTC_1312 1218-2183 165 µM -0.574139196623068 0.30564516460685 no 2329 0.282936805440802 3492 6744073 SGTC_122 0236-0016 402.397 µM -0.575742284236188 0.305170025025471 no 2330 0.282394694984579 3524 6808838 SGTC_47 0149-0135 24.25 µM -0.576262944191124 0.305015777037632 no 2331 0.282218732801258 3393 5239155 SGTC_3125 9127534 49.47 µM -0.576323508388387 0.304997836854444 no 2332 0.28219826795823 3405 1639235 SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.577596153204129 0.304620965468087 no 2333 0.281768402339756 3379 688803 SGTC_910 3454-3003 490 µM -0.57815187433237 0.304456463421109 no 2334 0.281580793553442 3486 820824 SGTC_811 0416-0114 265 µM -0.579296027634586 0.30411790091289 no 2335 0.281194722706782 3492 6612453 SGTC_977 1348-1378 135 µM -0.581163544681763 0.303565651031449 no 2336 0.2805651174079 3463 X977 SGTC_747 3448-8087 38.7 µM -0.58127305392483 0.303533281580408 no 2337 0.280528219196881 3440 5168703 SGTC_2854 9024559 71.43 µM -0.582858400300868 0.30306484743307 no 2338 0.279994313439848 3452 3163529 SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.583284412006849 0.302939025721334 no 2339 0.279850927173178 3409 4174840 SGTC_930 2810-3379 265 µM -0.583393379916854 0.302906846020833 no 2340 0.279814256667647 3558 1015764 SGTC_1605 st000082 49.1 µM -0.58554520745635 0.302271695919693 no 2341 0.279090589234357 3494 1114022 SGTC_1136 pergolide 1.05886 µM -0.585835680073214 0.302186003566822 no 2342 0.278992971993466 3435 47811 A dopamine receptor agonist. SGTC_493 zm226600 134 µM -0.587069147020019 0.301822239896149 no 2343 0.278578633876615 3543 5240098 A potassium channel opener. YCR052W RSC6 SGTC_591 4299-0174 154 µM -0.587152269855145 0.301797733090278 no 2344 0.27855072258206 3414 5509088 SGTC_82 0054-0107 293.755 µM -0.589251450166035 0.301179136080822 no 2345 0.277846303932544 3513 3104697 SGTC_2678 equilin 100 µM -0.592773781070322 0.300142443464075 no 2346 0.276666278331925 3543 3247 Equilin is an estrone commonly used hormone replacement therapy SGTC_2170 morpholine 200 µM -0.593609999297596 0.299896564903591 no 2347 0.276386495764931 3508 121171 Reacts with secondary amines. SGTC_665 3914-0008 307 µM -0.594300096437381 0.29969371994981 no 2348 0.276155707076196 3454 1069549 SGTC_1308 1187-1617 41.4 µM -0.599457502943601 0.29817974026899 no 2349 0.274433920531291 3515 2882570 SGTC_3087 9117406 49.47 µM -0.599700626578212 0.29810845629718 no 2350 0.274352885298233 3508 42546093 SGTC_973 1325-0077 65.9 µM -0.602958279621839 0.29715406072534 no 2351 0.273268221972729 3532 2835149 SGTC_1455 4262-0120 131 µM -0.605298432031158 0.296469328925922 no 2352 0.27249036153265 3603 1529587 SGTC_737 1950-0117 57.9 µM -0.608562644583791 0.295515425568888 no 2353 0.271407185601838 3519 5393513 SGTC_1047 2043-3044 82 µM -0.608759141821052 0.295458048094665 no 2354 0.271342049705793 3494 669592 SGTC_542 3381-0244 89.3 µM -0.610237862810537 0.295026423918696 no 2355 0.27085212584436 3570 1112843 SGTC_12 0849-0099 9.267 µM -0.611199172364204 0.294745982959519 no 2356 0.270533865620525 3484 6071388 SGTC_2428 5615643 7.78 µM -0.611578132547424 0.294635463435123 no 2357 0.270408454843841 3529 2253075 SGTC_1830 st055982 50.3 µM -0.612507353682216 0.294364547359871 no 2358 0.27010106707834 3523 455313 An antimicrobial agent. SGTC_2137 5261020 140 µM -0.613078903420976 0.29419796816923 no 2359 0.269912084419158 3521 763655 SGTC_725 1497-0963 19 µM -0.613142337195108 0.294179482967989 no 2360 0.269891114151998 3561 3549977 SGTC_540 1187-0821 17.3 µM -0.615631051566247 0.293454672015949 no 2361 0.269069026238279 3505 847520 SGTC_936 3005-4620 401 µM -0.616424119755526 0.293223873472989 no 2362 0.268807319210287 3573 777207 SGTC_1102 cgs 12066b 26.1 µM -0.617452505309831 0.292924718292844 no 2363 0.2684681495594 3500 6438352 A 5-HT1B full agonist. SGTC_597 k018-0003 82.8 µM -0.617497271977769 0.292911698981641 no 2364 0.268453390048364 3596 6786234 SGTC_1573 oleylamine 1.06 µM -0.618652395903701 0.292575851812631 no 2365 0.268072688361382 3557 5356789 An amine of the fatty acid oleic acid. SGTC_1364 1653-0028 37.6 µM -0.619748913723661 0.292257209747273 no 2366 0.267711553476874 3514 5718652 SGTC_2420 aureobasidin a 50 nM -0.621688783933004 0.291693889863156 no 2367 0.267073264084743 3615 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1 SGTC_3301 9125354 19.7965 µM -0.622440454586979 0.291475747965295 no 2368 0.266826143225662 3535 41905162 SGTC_585 0kpi-0023 191 µM -0.622599776495954 0.291429521023233 no 2369 0.266773779056686 3513 64601 SGTC_1928 4'-methoxychalcone 40.3 µM -0.622925331460992 0.291335072519486 no 2370 0.26666679538994 3615 641818 SGTC_2862 9027634 71.43 µM -0.623837384746349 0.291070547924863 no 2371 0.266367192558575 3515 5012562 SGTC_3294 9122953 26.2835 µM -0.623848448267929 0.291067339838906 no 2372 0.266363559318522 3563 16459826 SGTC_1275 0867-0008 21.1 µM -0.624458572542948 0.290890447865622 no 2373 0.266163234464089 3508 3422836 SGTC_1546 5-methoxyflavanone 78.7 µM -0.624670929638201 0.290828891435322 no 2374 0.266093528201058 3590 147795 SGTC_1697 st025554 27.742 µM -0.62697069473883 0.29016264374505 no 2375 0.265339222477461 3547 1269519 SGTC_2104 5389443 200 µM -0.629157992785717 0.289529642378026 no 2376 0.2646228134805 3607 2244536 SGTC_515 4092-1064 102 µM -0.629664402764845 0.28938318045137 no 2377 0.264457088642757 3601 717353 SGTC_281 1672-3440 14.9 µM -0.632972739673134 0.288427213685837 no 2378 0.263375722442619 3563 6833000 SGTC_1628 st004252 77.7 µM -0.633793291558168 0.28819034015094 no 2379 0.26310786589365 3557 692968 SGTC_2024 5144227 134 µM -0.634205145708513 0.288071482393853 no 2380 0.262973474923343 3561 3475211 SGTC_1 0258-0098 57.368 µM -0.635179721897364 0.287790319814479 no 2381 0.26265560352324 3493 6790032 YDR047W HEM12 SGTC_853 0419-0306 21 µM -0.637082451468309 0.287241761429934 no 2382 0.262035569255065 3497 762713 SGTC_2088 5278280 127.392 µM -0.639868641665085 0.286439394693529 no 2383 0.261129001125408 3613 791502 SGTC_714 4296-0578 26.1 µM -0.642371264669188 0.285719597605554 no 2384 0.260316076349757 3582 1589775 SGTC_1811 st050069 61.5 µM -0.645101504561165 0.284935316795218 no 2385 0.259430704456323 3581 3877702 SGTC_805 3852-0218 479 µM -0.64520948824383 0.284904318835518 no 2386 0.259395719127801 3553 6615355 SGTC_2029 5175081 200 µM -0.64644201372806 0.284550622215197 no 2387 0.258996569416765 3592 1380876 SGTC_953 1188-0045 9.7 µM -0.646998684377154 0.284390943763339 no 2388 0.258816397475333 3578 6144426 SGTC_594 1487-1584 10.8 µM -0.648196299108585 0.284047558625438 no 2389 0.258428997646064 3562 5013332 SGTC_3089 9117425 49.47 µM -0.648963334487115 0.283827735260687 no 2390 0.258181037882484 3544 9401657 SGTC_2753 fluvastatin 17.09 µM -0.649151295860914 0.283773880156738 no 2391 0.258120294372197 3576 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5 SGTC_2697 mebhydrolin 72.4 µM -0.649843048258636 0.283575719897776 no 2392 0.257896804465724 3612 22530 H1 Histamine receptor antagonist. YIL048W NEO1 SGTC_1121 fusaric acid 630.51 nM -0.651223974811398 0.283180336347919 no 2393 0.257450958080899 3583 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler. SGTC_1973 st070275 50.2 µM -0.652473120655036 0.282822911913513 no 2394 0.257048003667896 3556 17118334 SGTC_785 1270-0111 65.3 µM -0.655558811868389 0.281940917392431 no 2395 0.25605401702868 3597 6741994 SGTC_2560 caryophyllene 100 µM -0.655728232872261 0.281892529558964 no 2396 0.255999499950361 3634 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor. SGTC_3247 9135149 49.47 µM -0.656111665321983 0.281783033324501 no 2397 0.255876139638576 3579 8934436 YOR116C RPO31 SGTC_1417 3966-0327 90.4 µM -0.656731002894491 0.281606213324747 no 2398 0.255676947984077 3642 651118 SGTC_2382 9035899 200 µM -0.656824344807253 0.281579568981554 no 2399 0.255646934335137 3645 6462679 SGTC_1189 1431-2119 7.28 µM -0.658420613253105 0.281124104254295 no 2400 0.255133946717818 3635 3107275 SGTC_1076 itraconazole 331 nM -0.659337187498185 0.280862738221363 no 2401 0.254839633720529 3636 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1 SGTC_554 4483-2211 187 µM -0.659659480560022 0.280770862560365 no 2402 0.254736187310655 3585 747107 SGTC_1236 0330-0013 258 µM -0.660810329016883 0.280442910356482 no 2403 0.254366978964357 3592 4617066 SGTC_766 1391-0721 126 µM -0.661112025075743 0.280356968051521 no 2404 0.254270237054549 3624 1020919 YIL115C NUP159 SGTC_902 1120-0002 2.07 µM -0.661645372684274 0.280205067800088 no 2405 0.25409926092497 3610 3280475 SGTC_2415 st077333 57.7 µM -0.662496192553196 0.279962832320641 no 2406 0.253826637069717 3665 2766255 SGTC_105 0111-0055 734.78 µM -0.664163118187652 0.279488539296092 no 2407 0.253292958057523 3574 5179370 SGTC_1803 st050068 52.4 µM -0.665766366388195 0.279032732947237 no 2408 0.252780222962178 3700 3984059 YIL048W | YNL267W NEO1 | PIK1 SGTC_1497 4476-2978 41.3 µM -0.665785082904352 0.279027413943545 no 2409 0.252774240458473 3645 1528379 SGTC_7 0192-1582 4.227 µM -0.66624918317509 0.278895538127935 no 2410 0.25262592037262 3660 252616 SGTC_1103 duloxetine 36.1 µM -0.666354280895861 0.27886567843201 no 2411 0.252592338948556 3680 60835 A selective serotonin reuptake inhibitor. SGTC_2275 7947463 200 µM -0.668014219302344 0.278394273713666 no 2412 0.2520622579791 3588 1225414 SGTC_2864 9034755 47.6 µM -0.671752681839699 0.277334014784186 no 2413 0.250870578465882 3627 4930451 SGTC_351 caspofungin 25 nM -0.672104630801149 0.277234300931357 no 2414 0.250758544334027 3675 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1 SGTC_1241 0364-0022 50.8 µM -0.674940831465524 0.27643139189342 no 2415 0.249856678748884 3634 4563895 SGTC_618 k072-0232 33.2 µM -0.677180202089265 0.275798248073396 no 2416 0.249145813722125 3621 5872756 YGL099W LSG1 SGTC_2207 7258803 200 µM -0.677374108031066 0.275743458020361 no 2417 0.249084310934626 3598 3666799 SGTC_2002 4023503 131 µM -0.677630853286448 0.275670920326164 no 2418 0.249002889299232 3697 4736863 YCR052W RSC6 SGTC_1065 prochlorperazine maleate 2.48 µM -0.678627073229668 0.275389549260839 no 2419 0.248687092155009 3683 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine. SGTC_3269 9137823 49.47 µM -0.6795455853367 0.275130251163299 no 2420 0.248396117137669 3585 17682936 SGTC_476 mead acid 10 µM -0.679911972830883 0.275026852679127 no 2421 0.248280100065071 3658 5312531 An omega 9 fatty acid. SGTC_379 3970-0972 5.9 µM -0.682419166386859 0.274319809853415 no 2422 0.247486969891725 3650 2898042 YBL034C STU1 SGTC_2217 6934799 96.0675 µM -0.683570442479117 0.27399544437626 no 2423 0.247123227196114 3600 675606 SGTC_2988 9073640 71.4286 µM -0.683956832825262 0.273886623598662 no 2424 0.247001212289172 3674 9102229 SGTC_1522 st012842 45.6 µM -0.684367422281607 0.273771010942709 no 2425 0.24687159108535 3575 3491067 YOR116C RPO31 SGTC_1465 k213-0056 144 µM -0.685552129980412 0.273437559542056 no 2426 0.246497788487902 3563 24048857 YMR208W ERG12 SGTC_2135 5326629 150.42 µM -0.685584980539128 0.273428316190632 no 2427 0.246487427701954 3632 5020077 SGTC_1625 st003711 30.1 µM -0.685735553320993 0.273385950637129 no 2428 0.2464399413172 3698 24207034 YER133W GLC7 SGTC_2764 methyldopa 94.69 µM -0.686651681010157 0.273128256615227 no 2429 0.246151126312275 3675 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. SGTC_2006 4011487 200 µM -0.687872456836477 0.272785056474853 no 2430 0.245766551355069 3687 45595294 SGTC_1245 0418-0076 17.2 µM -0.689305290649764 0.272382512982619 no 2431 0.245315584631461 3658 6790114 SGTC_710 3448-4187 58 µM -0.689928814779736 0.272207430925435 no 2432 0.245119477110762 3686 3946412 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.690346623533263 0.272090143889347 no 2433 0.244988117297036 3646 803109 SGTC_779 1360-0071 233 µM -0.690896840291218 0.271935725694102 no 2434 0.244815185967281 3714 7566 SGTC_3332 9141069 11.198 µM -0.691683854129895 0.271714926254402 no 2435 0.244567944338259 3625 17332883 SGTC_1306 1185-0270 9.02 µM -0.692140303323801 0.271586908762255 no 2436 0.24442461175328 3662 1548076 SGTC_2161 5662504 8.5105 µM -0.694661404219213 0.270880372656839 no 2437 0.243633760496422 3642 2859334 SGTC_2831 7999036 19.48 µM -0.694743742552807 0.270857312895553 no 2438 0.243607954873473 3667 2988270 SGTC_1488 4013-0813 75.9 µM -0.695335705888099 0.270691555861689 no 2439 0.243422471351185 3645 2910057 SGTC_2934 9036370 36.88 µM -0.695539545571099 0.270634489963096 no 2440 0.243358618672301 3684 6462800 SGTC_79 0052-0007 94.094 µM -0.696508225654691 0.270363385466609 no 2441 0.243055303866787 3702 2801472 SGTC_947 3447-0010 211 µM -0.696625451439389 0.270330586696236 no 2442 0.243018611797165 3678 748350 SGTC_2136 5328288 199.296 µM -0.697440865062394 0.270102496002706 no 2443 0.242763467479144 3664 262395 SGTC_2376 9072922 81.32 µM -0.702541957284625 0.268677787121788 no 2444 0.241170622672684 3699 17087968 SGTC_2354 9060492 162 µM -0.70405288187789 0.26825651964042 no 2445 0.240699920838851 3711 6471895 SGTC_1202 1988-0068 29.6 µM -0.7050332458398 0.267983357956767 no 2446 0.240394773458356 3630 2850480 SGTC_1231 0242-0792 125 µM -0.705120877183355 0.267958947799595 no 2447 0.240367507652827 3679 3707635 SGTC_2389 9091542 195.52 µM -0.706190440783222 0.267661105668132 no 2448 0.240034857121977 3700 3626624 YOL127W RPL25 SGTC_244 nsc-207895 1.295 µM -0.708043329063392 0.267145525776242 no 2449 0.239459175260697 3558 42640 SGTC_1027 k015-0025 8.67 µM -0.708291118287548 0.267076614613418 no 2450 0.239382245751363 3665 3598955 SGTC_1520 flindersine 88 µM -0.708844026996504 0.266922880879968 no 2451 0.23921063645459 3753 68230 Flindersine is a natural alkaloid of the quinoline subtype. SGTC_2314 7727897 200 µM -0.70923746645822 0.266813514068233 no 2452 0.239088563447607 3701 900724 SGTC_2546 rhodinyl acetate 100 µM -0.710886271212973 0.266355431987209 no 2453 0.238577357061595 3661 6708682 SGTC_492 tmb-8 126 µM -0.71381480604788 0.26554278898366 no 2454 0.237670851499077 3590 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1 SGTC_132 0417-1715 25.805 µM -0.714803975086667 0.265268587581667 no 2455 0.237365089282456 3709 6769098 SGTC_337 1315-0038 354 µM -0.717003104778252 0.264659495969426 no 2456 0.236686090458411 3699 1626437 SGTC_2857 9024691 58.44 µM -0.718497688305237 0.264245948451222 no 2457 0.236225236372907 3759 16478292 SGTC_2005 4024620 188 µM -0.718773897469455 0.264169558109627 no 2458 0.236140121551593 3709 236743 SGTC_3128 9127691 49.47 µM -0.718992325790087 0.26410915600886 no 2459 0.2360728240636 3691 41316314 SGTC_1917 st066507 28.5 µM -0.719623377511709 0.263934690473175 no 2460 0.235878457205795 3679 3156428 SGTC_2596 sinensetin 100 µM -0.720449221318084 0.263706459956978 no 2461 0.235624226797243 3731 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets. SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.721592408119546 0.263390694610036 no 2462 0.235272554061788 3729 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1 SGTC_2195 6536160 144.242 µM -0.722373862429648 0.263174956337417 no 2463 0.235032326099691 3636 3834386 SGTC_3155 9099265 49.47 µM -0.724172606813029 0.262678715229906 no 2464 0.234479886860941 3679 25236499 SGTC_1946 st076057 65.1 µM -0.724975698895237 0.262457311307995 no 2465 0.234233469427281 3598 953009 SGTC_2365 9042475 200 µM -0.725160257538839 0.26240644396249 no 2466 0.234176860486102 3760 6464479 SGTC_919 tnp00227 403.569 nM -0.725384164390825 0.262344738392556 no 2467 0.234108192595668 3723 1269246 A methoxyflavone. YNL221C POP1 SGTC_308 4092-1169 104 µM -0.725464689724209 0.262322548563555 no 2468 0.234083499763588 3676 2268590 YDL196W YDL196W SGTC_2480 5767542 37.17 µM -0.72670479530083 0.261980942376112 no 2469 0.233703407619695 3712 2867358 SGTC_2200 6600604 21.907 µM -0.728067977202279 0.26160569623926 no 2470 0.233285987651758 3682 2904777 SGTC_3135 9127742 49.47 µM -0.728389248192028 0.261517299439726 no 2471 0.233187671533831 3770 3643468 SGTC_295 k015-0027 31 µM -0.730851540505812 0.260840316219779 no 2472 0.232434919086427 3689 3887424 SGTC_155 k072-0202 43.6 µM -0.730862513441126 0.260837301337331 no 2473 0.232431567555332 3652 5857737 SGTC_1872 amphotericin b 148 nM -0.731323347188264 0.260710700576795 no 2474 0.232290836540951 3740 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1 SGTC_1445 4239-0156 97.7 µM -0.731578115942555 0.260640723796321 no 2475 0.23221305472568 3796 4008346 SGTC_1326 1431-2094 10.8 µM -0.733368639760571 0.260149197379007 no 2476 0.231666810447274 3705 616278 SGTC_2177 5811945 192 µM -0.733943299867646 0.259991545654703 no 2477 0.231491647850442 3757 5343475 SGTC_3316 9136639 10.545 µM -0.734497917084486 0.259839439212779 no 2478 0.231322664585445 3764 4903665 SGTC_3143 9086658 49.47 µM -0.735700107829825 0.259509890301222 no 2479 0.230956612017068 3804 25236626 SGTC_2639 lactacystin 53 µM -0.738801364112663 0.258660760306435 no 2480 0.230013811687207 3756 3870 A proteasome inhibitor. SGTC_3082 9117008 49.47 µM -0.738853807118543 0.258646413686952 no 2481 0.229997887242306 3801 41448529 SGTC_628 1636-0253 16 µM -0.739919651791364 0.258354924197926 no 2482 0.229674374674942 3746 4456143 SGTC_1836 st055642 81 µM -0.740373840644225 0.258230763398023 no 2483 0.229536593608963 3759 8571 SGTC_1740 st038286 13.222 µM -0.74252527475668 0.25764305020808 no 2484 0.228884572077917 3760 716786 SGTC_2717 st081029 62.2815 µM -0.743963172903935 0.257250643167267 no 2485 0.228449377539255 3736 5292846 SGTC_45 0kpi-0036 14.9 µM -0.744239456349363 0.25717528012249 no 2486 0.228365810815713 3720 2795021 SGTC_3219 9131112 49.47 µM -0.745506234677049 0.256829882489082 no 2487 0.227982871755182 3705 17612988 YMR079W SEC14 SGTC_1714 st033236 13.627 µM -0.745832130459599 0.256741063358266 no 2488 0.227884413973421 3761 2916566 SGTC_1093 fluphenazine 7.97 µM -0.748335907036919 0.25605922169437 no 2489 0.22712878567405 3784 6602611 An atypical antipsychotic. SGTC_216 k038-0035 28.382 µM -0.75114435169542 0.255295536655023 no 2490 0.226282893160602 3671 4444231 YPR107C YTH1 SGTC_1329 1447-1697 50.6 µM -0.75161292941911 0.255168234869981 no 2491 0.226141932828384 3780 2840515 SGTC_2597 laccaic acid a 100 µM -0.755864219994845 0.254014775635598 no 2492 0.224865304066336 3773 5491415 A textile dye. SGTC_928 2764-0428 58.7 µM -0.756111786227018 0.25394769041163 no 2493 0.224791087997621 3810 662578 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.756136240367654 0.253941064360214 no 2494 0.224783757823591 3784 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair. SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.756818225478921 0.253756311414106 no 2495 0.224579386125956 3688 17037758 SGTC_1204 4049-0315 18.3 µM -0.757588919893106 0.253547611678019 no 2496 0.224348557680088 3854 588402 SGTC_3352 9151559 45.5865 µM -0.757774899942826 0.253497262830232 no 2497 0.224292875512967 3766 17159339 SGTC_1452 4194-0072 190 µM -0.758027171458316 0.253428975836558 no 2498 0.224217358314422 3762 1343545 SGTC_1077 5-fluorocytosine 377 nM -0.758780360494622 0.253225153772681 no 2499 0.223991977932486 3799 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_3347 9188721 44.724 µM -0.759123342067248 0.253132367382223 no 2500 0.223889388571831 3801 44118411 YKL104C | YBL026W GFA1 | LSM2 SGTC_712 r015-0009 80.6 µM -0.759247421020432 0.253098804858335 no 2501 0.223852281842864 3783 6813872 YLR060W FRS1 SGTC_1233 0325-0408 14.2 µM -0.760244929276798 0.252829070648836 no 2502 0.223554096648902 3819 12874 SGTC_976 1348-1067 47.6 µM -0.761134291136541 0.252588707760741 no 2503 0.223288430270411 3806 5310671 YGL099W LSG1 SGTC_1423 4048-0112 5.59 µM -0.761793110758661 0.252410729888424 no 2504 0.223091746392783 3786 X1423 SGTC_1523 st012844 44.7 µM -0.766019330546779 0.2512706048015 no 2505 0.221832400156413 3891 4274103 SGTC_1832 st054113 55 µM -0.766020735315752 0.251270226284292 no 2506 0.221831982233809 3734 1251267 SGTC_2819 7996655 46.38 µM -0.768174051651834 0.250690366427721 no 2507 0.221191893638877 3716 6456960 SGTC_1938 st074717 56.4 µM -0.769765551949325 0.250262252163219 no 2508 0.220719488681038 3653 17250979 SGTC_2355 9061122 103.12 µM -0.770633355725922 0.250028976001394 no 2509 0.220462142167113 3817 5302957 SGTC_3328 9140624 29.0385 µM -0.771505138830145 0.249794746366756 no 2510 0.220203788817208 3787 4904392 SGTC_1796 st049173 110.4 µM -0.772989521576988 0.249396192417972 no 2511 0.219764290993059 3734 94134 SGTC_9 0092-0002 10.449 µM -0.774291855153911 0.249046796882962 no 2512 0.219379109561339 3769 759368 SGTC_2430 5571206 200 µM -0.774855715888606 0.248895602778201 no 2513 0.219212461114703 3822 1731771 SGTC_2661 dactinomycin 12.96 µM -0.776358802032987 0.248492802780083 no 2514 0.21876858130706 3786 45006140 An Actinomycin D Classic transcription inhibitor. SGTC_395 anisomycin 6.25 µM -0.776382242990285 0.248486523777929 no 2515 0.218761663002893 3801 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. SGTC_2681 menadione 3.18 µM -0.776915063048095 0.248343822962027 no 2516 0.218604441813807 3830 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_833 3852-0053 558 µM -0.777503193680201 0.248186359507545 no 2517 0.218430975481031 3856 3123681 SGTC_929 2805-0021 398 µM -0.778210759914758 0.247996989487274 no 2518 0.21822238728314 3879 3098024 SGTC_2369 9071472 200 µM -0.779296320720175 0.247706604555384 no 2519 0.217902590764915 3885 17296037 SGTC_627 1391-0720 175 µM -0.779586975173015 0.247628886008794 no 2520 0.217817012448475 3806 997839 SGTC_1905 st060207 84.5 µM -0.779684320047839 0.247602859723007 no 2521 0.217788355221016 3712 1948547 SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.779830830450613 0.24756369121552 no 2522 0.217745228319695 3798 61125 An anti-inflammatory. SGTC_872 0588-0139 234 µM -0.780768433987168 0.247313108014664 no 2523 0.217469351382877 3794 2047100 SGTC_1010 4112-3296 15.2 µM -0.780979468651174 0.247256725752711 no 2524 0.217407285167412 3866 704384 SGTC_390 dec-rvkr-cmk 16.7 µM -0.781260678750693 0.24718160535831 no 2525 0.217324595946341 3856 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1 SGTC_876 0720-0963 56.8 µM -0.781352771564077 0.247157007015879 no 2526 0.217297520202201 3802 765861 SGTC_1350 1495-0454 146 µM -0.783024393922175 0.246710737943153 no 2527 0.216806393650251 3806 1069057 SGTC_537 1334-0398 209 µM -0.784452756882339 0.246329753393469 no 2528 0.216387246253156 3781 5846986 SGTC_2852 9023854 51.95 µM -0.784949951745897 0.246197211581188 no 2529 0.216241456522308 3885 19798528 SGTC_2340 7987427 183.45 µM -0.785778034106221 0.245976546957023 no 2530 0.215998768739312 3815 2239331 SGTC_3048 9093155 49.47 µM -0.786114504124593 0.245886915878662 no 2531 0.215900203885812 3729 25236002 SGTC_25 0118-0223 35.662 µM -0.786667093516417 0.24573975155288 no 2532 0.215738386017487 3818 5333628 SGTC_427 1354-0053 47.3 µM -0.786804492637735 0.245703167079877 no 2533 0.215698161574428 3935 6813657 SGTC_2254 7938975 95.19 µM -0.787121711482716 0.245618714215916 no 2534 0.215605310403229 3850 2969277 SGTC_1500 4488-1866 171 µM -0.78837832781352 0.245284319735955 no 2535 0.215237721820513 3918 2900003 SGTC_1207 2099-0101 141 µM -0.788505781521383 0.245250417079592 no 2536 0.215200459067357 3847 5837381 SGTC_193 1273-0060 1.558 µM -0.788581653777251 0.245230236273649 no 2537 0.215178278602244 3668 2847393 YHR072W ERG7 SGTC_1213 1315-0166 115 µM -0.789427401623748 0.245005341338527 no 2538 0.214931122867106 3886 768401 SGTC_1028 k015-0029 4.8 µM -0.790494194398294 0.244721826112061 no 2539 0.214619605703354 3792 4588309 SGTC_146 3448-8650 53.125 µM -0.792651845672574 0.244148940184972 no 2540 0.21399034665885 3800 2891488 YIL048W NEO1 SGTC_2709 st078560 56 µM -0.792791005077514 0.244112016300634 no 2541 0.21394979900537 3800 17250903 SGTC_1924 st058459 75.1 µM -0.793394736345379 0.243951860041626 no 2542 0.213773938255396 3755 688683 SGTC_1113 artemisinin 1.17947 µM -0.795098495316013 0.243500197192961 no 2543 0.213278104932853 3823 2240 An anti-malaria and mitochondrial poison. SGTC_645 0845-0943 5.41 µM -0.795393129835313 0.243422136052051 no 2544 0.213192427523885 3843 1885106 SGTC_1781 st038725 66.3 µM -0.796194792899291 0.243209810073364 no 2545 0.212959411821766 3824 4270275 YIL048W NEO1 SGTC_2396 5342950 42.78 µM -0.796626027183994 0.243095636134019 no 2546 0.212834128440724 3845 1886677 SGTC_1908 st060353 56.5 µM -0.796964160184391 0.243006132044064 no 2547 0.212735923201671 3855 4227716 SGTC_576 1073-0113 22.7 µM -0.79743617463908 0.24288121923512 no 2548 0.212598878519566 3981 5439563 SGTC_2073 5212005 126 µM -0.798029627473787 0.242724218568679 no 2549 0.2124266486024 3664 691789 SGTC_1775 st081588 35.1725 µM -0.79891815901745 0.242489256215712 no 2550 0.212168934375103 3853 1426443 YGL099W LSG1 SGTC_2986 9022445 71.43 µM -0.799302072998224 0.242387772532772 no 2551 0.212057638578086 3759 6459286 SGTC_1001 4048-4355 44.4 µM -0.799657742063865 0.24229377563864 no 2552 0.211954561389508 3818 21824233 SGTC_2445 5742597 35.57 µM -0.799733406643368 0.242273781408929 no 2553 0.211932636662091 3787 1774255 SGTC_1277 0873-0036 22 µM -0.802791899615775 0.241466329218058 no 2554 0.211047512449321 3888 5965735 SGTC_3297 9117502 71.43 µM -0.803240322910312 0.241348066978592 no 2555 0.210917921665805 3851 7453720 SGTC_3019 9081971 49.47 µM -0.803461773018385 0.241289675766894 no 2556 0.210853941550845 3843 16451803 SGTC_3343 9148379 18.9835 µM -0.803708083926802 0.241224738362737 no 2557 0.21078279216515 3889 1955036 SGTC_1716 st033144 30.6155 µM -0.803898486286711 0.241174547197311 no 2558 0.210727802177691 3818 674617 SGTC_2288 7946289 167.31 µM -0.804496865272822 0.241016847988599 no 2559 0.210555039504759 3855 1246052 SGTC_1554 st069299 38.7 µM -0.808072572031982 0.240075661594064 no 2560 0.209524402968119 3782 24207999 SGTC_129 0088-0017 176.636 µM -0.80855054892272 0.239950002004996 no 2561 0.209386859491642 3710 182446 SGTC_852 0418-0143 439 µM -0.810131531649518 0.239534619069736 no 2562 0.208932291780114 3895 5369229 SGTC_139 0099-0334 718.624 µM -0.811482382388171 0.239180011617952 no 2563 0.208544353083119 3885 97690 SGTC_2739 tacrine 100.86 µM -0.813065390952511 0.238764826493711 no 2564 0.208090283947361 3887 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. SGTC_2973 9094665 17.96 µM -0.813444500562192 0.238665453699644 no 2565 0.207981627066824 3928 25237061 YIL048W NEO1 SGTC_3354 9151612 71.43 µM -0.813735547975998 0.238589179263261 no 2566 0.207898232489284 3883 27261949 SGTC_3161 9100388 49.47 µM -0.814062070665517 0.238503623747697 no 2567 0.20780469659405 3876 25236368 SGTC_1080 nisoldipine 24.4 µM -0.814088699758229 0.238496647130311 no 2568 0.207797069503698 3840 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class. SGTC_1877 wortmannin 25 µM -0.815451830866128 0.238139666547828 no 2569 0.20740686312867 3853 312145 A covalent inhibitor of PI 3-kinase. SGTC_617 3770-0098 35 µM -0.81680933521567 0.237784450698988 no 2570 0.207018698273923 3799 5962639 SGTC_2557 derrustone 83.84 µM -0.820816607727531 0.236737571685829 no 2571 0.205875368632459 3818 629853 An antioxidant. SGTC_481 bay k-8644 50 µM -0.822119104818482 0.236397847800732 no 2572 0.2055045566069 3840 2303 A calcium channel antagonist. SGTC_2926 9010726 65.15 µM -0.822544924558918 0.236286841577992 no 2573 0.205383414704526 3893 2994293 SGTC_1157 4092-0394 27.6 µM -0.822680163981584 0.236251592249771 no 2574 0.205344949176032 3969 3659885 SGTC_3065 9113888 49.47 µM -0.824877651480909 0.235679236575874 no 2575 0.204720527752481 3911 16648368 SGTC_75 0159-0059 199.013 µM -0.82553776036942 0.235507454676726 no 2576 0.204533177029157 3902 5377270 SGTC_1211 1056-0033 32.3 µM -0.826831516819968 0.23517097745874 no 2577 0.204166281862041 3850 6741922 SGTC_822 1487-0950 154 µM -0.827483582297721 0.235001490437319 no 2578 0.203981511893485 3855 1958375 SGTC_3111 9122088 49.47 µM -0.83281316305819 0.233618741129119 no 2579 0.202475054922295 3755 16876704 SGTC_3009 9080819 71.4286 µM -0.837823291977769 0.232322997334372 no 2580 0.201064977619893 3900 17027216 SGTC_1363 1636-0063 10.4 µM -0.838156468940593 0.232236971508111 no 2581 0.200971415863517 3883 6072185 SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.838388211551974 0.232177146343379 no 2582 0.200906354002192 3915 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W SGTC_2352 9027995 87.8 µM -0.839882182397804 0.231791678494202 no 2583 0.200487224330419 3849 2997347 SGTC_771 0250-0039 27.3 µM -0.83999055745855 0.231763729909217 no 2584 0.200456840429002 3860 3005115 SGTC_3130 9127414 49.47 µM -0.840066241041437 0.231744213164644 no 2585 0.200435623511111 3887 1494646 SGTC_486 niguldipine 82 µM -0.840378299748629 0.231663751354875 no 2586 0.200348156118507 3913 1236 A calcium channel blocker. SGTC_3106 9121286 49.47 µM -0.840504538391951 0.231631206166641 no 2587 0.200312779019596 3914 15943471 SGTC_23 0213-0011 39.996 µM -0.841116631267715 0.23147344056019 no 2588 0.20014129942609 3894 627608 SGTC_2685 mycophenolic acid 18.85 µM -0.844118678016242 0.230700537663282 no 2589 0.199301545682492 3876 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_2027 5150920 200 µM -0.844686657388414 0.230554468822564 no 2590 0.19914290550044 3868 786715 SGTC_3233 9132340 49.47 µM -0.844939530011459 0.230489453495781 no 2591 0.199072301078227 3906 17682950 SGTC_2046 4110841 106 µM -0.845906109418695 0.230241033616379 no 2592 0.198802562020586 3917 44119630 YMR134W ERG29 SGTC_572 0960-0087 17.7 µM -0.846726085156234 0.230030409696716 no 2593 0.198573907838098 3903 6796365 SGTC_163 TUB2.036 7.546 µM -0.847052314623612 0.22994664241745 no 2594 0.198482981307123 3911 15992207 YJR013W GPI14 SGTC_687 k029-0044 34.9 µM -0.848279708193969 0.229631632544556 no 2595 0.198141107813414 3957 5829338 SGTC_612 0302-0167 22.4 µM -0.852340557627786 0.228591142627252 no 2596 0.197012550856551 3922 235821 SGTC_3151 9099821 49.47 µM -0.854872665258207 0.227943696747792 no 2597 0.19631082236771 3870 17174189 SGTC_1499 4480-0877 67.3 µM -0.854958005599817 0.22792189368101 no 2598 0.196287198238071 3834 2861909 SGTC_1874 staurosporine 7.6 µM -0.855708119320595 0.227730302334589 no 2599 0.196079624018712 3964 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1 SGTC_2816 7982706 58.44 µM -0.857862783362614 0.227180470277814 no 2600 0.195484118382186 3981 2981853 SGTC_3025 9087895 49.47 µM -0.860221643718999 0.226579389851137 no 2601 0.194833438020818 3932 17173641 SGTC_1171 0368-0077 21.4 µM -0.86135949700023 0.226289765463599 no 2602 0.194520038146365 3870 3239779 SGTC_2409 alverine citrate 63.97 µM -0.862857565115563 0.225908772627852 no 2603 0.194107892203444 4113 21718 An antispasmotic used to treat irritable bowel syndrome. SGTC_1487 3970-0795 2.82 µM -0.863903494645937 0.225642984094728 no 2604 0.193820453464017 3965 3765103 SGTC_1826 st055655 41.6 µM -0.865430255067569 0.225255326062111 no 2605 0.193401340520658 3964 676168 SGTC_2397 5161689 200 µM -0.865674753025971 0.225193280917155 no 2606 0.193334274477255 3941 2259942 SGTC_1540 guanosine 70.6 µM -0.867803187352583 0.22465356685339 no 2607 0.192751042430462 3816 6802 Guanosine is a purine nucleoside SGTC_2537 larixol 68.93 µM -0.870117549467905 0.224067539999939 no 2608 0.192118084008668 3932 6708759 SGTC_2391 6285546 200 µM -0.871213217173455 0.223790405706921 no 2609 0.191818872238834 3920 846083 SGTC_529 4076-0302 30.3 µM -0.87126947714749 0.223776180770266 no 2610 0.191803516119231 3889 5816522 SGTC_2348 9022543 33.42 µM -0.87513532797673 0.222799959572843 no 2611 0.190750138379813 3988 3162678 YDL140C RPO21 SGTC_1641 st009299 47.1 µM -0.875591563486142 0.222684909343553 no 2612 0.190626056703601 3856 4046054 SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM -0.875847540895447 0.222620373611472 no 2613 0.190556460620059 3960 368090 SGTC_3249 9135183 49.47 µM -0.87731123543744 0.222251559184874 no 2614 0.190158805633732 3952 4902779 SGTC_1429 4049-0205 9.46 µM -0.87807675283771 0.222058806877065 no 2615 0.189951033902109 3949 22774478 SGTC_188 3229-0966 278.469 µM -0.878915013131009 0.221847847886872 no 2616 0.189723678914811 3974 5722370 SGTC_466 geldanamycin 89.2 µM -0.88076422708998 0.221382874413231 no 2617 0.189222722802639 3847 5288382 HSP90 inhibitor. SGTC_2248 tofa 1.1 µM -0.880907289825213 0.221346925406833 no 2618 0.189184000764771 3861 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner SGTC_1673 st016611 27.3 µM -0.881889584568294 0.221100183163317 no 2619 0.1889182600002 3987 5226799 SGTC_2911 7942208 15.64 µM -0.883715615803187 0.220641921546951 no 2620 0.188424874218184 3985 1243384 SGTC_232 clozapine 119 µM -0.883959324004482 0.22058080160885 no 2621 0.188359085475296 3905 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_1647 st011722 22.4 µM -0.885621628983836 0.220164168515372 no 2622 0.187910726225406 3919 2854783 SGTC_1208 2323-2347 50.3 µM -0.887894301713307 0.219595286404227 no 2623 0.187298805091531 3965 5412760 SGTC_162 k030-0015 37.8 µM -0.888095807447336 0.219544887446651 no 2624 0.187244608842735 4034 1809920 YMR134W ERG29 SGTC_154 3389-1638 511.116 µM -0.888583198282135 0.219423012731107 no 2625 0.187113562074976 3962 5238686 SGTC_2990 9074105 71.4286 µM -0.888655022021973 0.219405056103103 no 2626 0.187094255329042 3895 6502001 SGTC_1700 st030840 7.9285 µM -0.889755346874841 0.219130069840879 no 2627 0.186798634023462 3990 5499307 SGTC_2437 5741531 144.16 µM -0.891261528938629 0.218753975764963 no 2628 0.186394441179108 3987 2262990 SGTC_3256 9138902 49.47 µM -0.895904820926499 0.21759688502091 no 2629 0.185151799580286 4022 17228773 SGTC_1760 st045453 10.4495 µM -0.896420794318747 0.217468524823997 no 2630 0.185014032728788 4017 3323419 YIL048W NEO1 SGTC_1925 st057770 10.1 µM -0.898584415286078 0.21693075073726 no 2631 0.184437031476446 3954 5989122 SGTC_2645 abamectin 100 µM -0.898589400471746 0.216929512543581 no 2632 0.184435703305325 3915 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels. SGTC_4 0960-0234 25.671 µM -0.898894779867682 0.216853671837209 no 2633 0.184354354372244 3969 6821112 SGTC_1257 0669-0121 16 µM -0.89909616059244 0.216803667498476 no 2634 0.184300721492495 3987 4307855 SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.899705122486642 0.21665249827817 no 2635 0.184138598314954 4020 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis. SGTC_1591 genipin 88.4 µM -0.902249481667034 0.216021544282813 no 2636 0.183462177446799 4017 442424 A DNA cross-linking agent. SGTC_2322 7413319 38.22 µM -0.904709880893422 0.215412424376516 no 2637 0.182809552535302 4033 1840400 SGTC_349 k015-0014 24 µM -0.908135898276733 0.214565908733764 no 2638 0.181903213085095 3967 2196908 SGTC_263 alizarin 107.927 µM -0.908795950465534 0.214403042548283 no 2639 0.181728922279341 3989 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. SGTC_988 1497-1057 103 µM -0.908905328759662 0.214376060679963 no 2640 0.181700050368302 3894 3533044 SGTC_1788 fluconazole 20 µM -0.908962943720067 0.214361848788748 no 2641 0.181684843258054 4037 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11 SGTC_2919 7978188 46.38 µM -0.909261049536913 0.21428832373352 no 2642 0.181606172803327 3964 2980291 SGTC_2935 9038016 29.96 µM -0.910049718737591 0.214093876492994 no 2643 0.181398144951806 3982 6463195 SGTC_3080 9117754 49.47 µM -0.910385598477249 0.214011096168945 no 2644 0.181309595023802 3994 9550191 SGTC_1427 4048-4900 550 nM -0.910793346660512 0.213910628316988 no 2645 0.181202134381994 3972 24132586 SGTC_2978 9011784 42.97 µM -0.910855692175482 0.213895269001632 no 2646 0.181185706951141 3983 2994934 SGTC_2529 gangaleoidin 93.61 µM -0.912337883047386 0.213530308579118 no 2647 0.180795438947962 4005 4565183 SGTC_2879 9041815 71.43 µM -0.912881739479168 0.21339648566046 no 2648 0.180652371178433 3996 4942971 SGTC_885 0865-0106 16.8 µM -0.91430240162862 0.213047144080303 no 2649 0.180278984497212 3902 2793380 SGTC_2658 polymyxin b sulfate 77.05 µM -0.915544287526525 0.212742037163771 no 2650 0.179952981856482 4007 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides.  YIL048W NEO1 SGTC_3340 9146634 11.102 µM -0.915733179864005 0.212695652396892 no 2651 0.179903428919555 4024 4907387 SGTC_2899 9053889 58.44 µM -0.917329358162069 0.212303927618669 no 2652 0.179485038860256 3950 6470052 SGTC_741 4582-0002 126 µM -0.917945900913913 0.212152732245587 no 2653 0.179323594636224 3956 2912688 SGTC_2069 5228469 200 µM -0.920372465304878 0.211558275293687 no 2654 0.178689076207104 4010 2835210 SGTC_42 0133-0086 60.653 µM -0.920956239980684 0.211415408505612 no 2655 0.178536637115219 3883 162923 Model of phenazepam hydroxylation. SGTC_757 1066-0008 322 µM -0.921752883351459 0.211220537696804 no 2656 0.178328744543788 4039 6842497 SGTC_2493 resveratrol 26.09 µM -0.923535831041732 0.210784783741317 no 2657 0.177864018340724 3871 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase. SGTC_2038 4100038 30.985 µM -0.925149021822849 0.210390973256645 no 2658 0.177444198218683 3997 3596803 SGTC_1640 st009078 66.4 µM -0.925474201897499 0.210311642971009 no 2659 0.177359648497188 3974 690618 SGTC_558 k064-0027 21.3 µM -0.925825762846995 0.210225896621637 no 2660 0.177268268133541 4021 5088526 SGTC_3028 9087778 49.47 µM -0.926474364542177 0.210067755391612 no 2661 0.177099756750689 3980 17217395 SGTC_2485 5633444 17.78 µM -0.926798723928444 0.209988696726261 no 2662 0.177015523820341 4028 5724239 SGTC_3126 9127922 49.47 µM -0.929480201444431 0.209335789128733 no 2663 0.176320140504083 4067 45595682 SGTC_111 0083-0039 52.457 µM -0.930445642686546 0.209101008595555 no 2664 0.17607019793048 3894 759313 SGTC_2037 5169046 200 µM -0.931975716997033 0.208729235701747 no 2665 0.17567453748961 4071 5718022 SGTC_1884 5633444 25 µM -0.932073082414758 0.208705591333624 no 2666 0.175649378939098 4016 5724239 SGTC_3071 9117417 49.47 µM -0.934403562194219 0.208140125259755 no 2667 0.175047880467894 3948 45595590 YGL055W OLE1 SGTC_2798 7813637 45.45 µM -0.934725807255959 0.208062007148037 no 2668 0.174964811748589 4029 956368 SGTC_468 gf-109203x 121 µM -0.936497391418372 0.207632851859831 no 2669 0.17450857751381 3979 2396 A protein kinase C inhibitor. SGTC_3220 9131269 49.47 µM -0.938336708809498 0.207187842481314 no 2670 0.174035700242815 4031 17722206 SGTC_2655 perillic acid 100 µM -0.939237809903607 0.206970033706675 no 2671 0.173804330243664 4042 5702197 An apoptosis inducer. SGTC_1398 3558-0053 112 µM -0.940031911164524 0.20677820065811 no 2672 0.173600596163703 3911 4532369 SGTC_1119 parthenolide 318.541 nM -0.941942367915143 0.206317118259851 no 2673 0.173111073539509 4133 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs. SGTC_2969 9091408 28.7 µM -0.942958759491635 0.206072064043928 no 2674 0.172850998840589 3976 4286311 SGTC_2675 theaflavin digallate 100 µM -0.943235191884815 0.20600544546019 no 2675 0.172780308298023 3972 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative. SGTC_153 4077-0274 519.67 µM -0.945780419012127 0.205392661111861 no 2676 0.172130297412363 4019 3121976 SGTC_182 3448-4371 550.524 µM -0.945884610800963 0.205367599169471 no 2677 0.172103721766752 3932 3491403 SGTC_899 1083-0020 478 µM -0.947269889821309 0.205034561456571 no 2678 0.171750634913406 4091 767123 SGTC_2186 6124449 200 µM -0.95098022045487 0.204144136248484 no 2679 0.170807208379805 4029 3834182 YLR033W RSC58 SGTC_416 estradiol valerate 100 µM -0.95151223645411 0.204016649242933 no 2680 0.17067220492966 4061 13791 A steroid. SGTC_1088 bifonazole 369 nM -0.952141662504413 0.203865881137027 no 2681 0.170512571109673 3980 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase. SGTC_1694 st024011 44.9 µM -0.952618774595224 0.203751641458696 no 2682 0.170391630586579 4053 2787533 SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.953112204576525 0.203633534778562 no 2683 0.170266611538267 4096 165506 SGTC_2328 6201408 200 µM -0.953915737296624 0.203441289754357 no 2684 0.170063148384834 4046 2890418 SGTC_2571 chrysanthemic acid 100 µM -0.956063098734618 0.202928065593448 no 2685 0.169520178322314 4068 2743 An insecticide. SGTC_2243 6634756 200 µM -0.956906942445774 0.202726596903138 no 2686 0.169307113389518 4132 885676 SGTC_2424 5537928 59.2 µM -0.957011321728746 0.202701684534188 no 2687 0.169280770265488 4072 5382802 SGTC_3105 9121040 49.47 µM -0.95714792394001 0.202669084231736 no 2688 0.169246298730889 3867 41448907 SGTC_1111 tnp00062 510.699 nM -0.957532217106684 0.202577388955924 no 2689 0.169149346617796 4082 676306 SGTC_3084 9116877 49.47 µM -0.960096552845474 0.201966154018848 no 2690 0.168503311615713 3960 27241325 SGTC_409 arachidonic acid 100 µM -0.960322228846833 0.201912414801357 no 2691 0.168446532942827 4043 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes. SGTC_2780 5215298 71.43 µM -0.964337083312918 0.200957806912533 no 2692 0.167438477336784 4085 2834131 SGTC_1630 st005209 31.3 µM -0.966389898215816 0.200470759128417 no 2693 0.166924558486679 3997 3367314 SGTC_2049 5262831 67.185 µM -0.966987366480622 0.200329138013834 no 2694 0.16677517463501 4063 763417 SGTC_1129 3453-1384 223 µM -0.967429151952291 0.200224457893782 no 2695 0.166664771341716 4172 1084452 SGTC_2627 acetyl isogambogic acid 100 µM -0.968058826378863 0.200075314715233 no 2696 0.166507495667226 4081 6857789 A caspase activator and apoptosis inducer. SGTC_943 3253-1379 105 µM -0.969770567263257 0.199670213534164 no 2697 0.166080433408688 4078 668464 SGTC_781 4335-2806 94.4 µM -0.9704378958043 0.19951241713253 no 2698 0.165914133498588 4134 845254 SGTC_1675 st018485 24.5 µM -0.97145834796303 0.199271266372171 no 2699 0.165660042506981 4102 3323024 SGTC_1174 0739-0097 51.1 µM -0.971952713625354 0.199154502233104 no 2700 0.165537036757572 4091 728447 SGTC_1937 st074714 47.2 µM -0.975533343331581 0.19831002486735 no 2701 0.164647885240959 4019 17250970 SGTC_2993 9054257 71.4286 µM -0.975805537822287 0.198245917381189 no 2702 0.164580419974927 3998 6470217 YGL055W OLE1 SGTC_607 4491-0986 66.8 µM -0.976059221210101 0.198186180909757 no 2703 0.164517558943045 4074 698981 YDR232W HEM1 SGTC_3083 9117465 49.47 µM -0.976534533541792 0.198074285292239 no 2704 0.164399821651655 4061 16420915 SGTC_2958 9077254 16.72 µM -0.977348216411663 0.197882820773136 no 2705 0.16419839507406 4143 16457351 SGTC_1420 4'-methoxyflavone 42 µM -0.977668792476829 0.197807417990693 no 2706 0.164119080681323 4040 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13 SGTC_3187 9109394 49.47 µM -0.978548173954084 0.1976006675801 no 2707 0.163901638679535 4080 17098090 SGTC_1294 1000-1494 117 µM -0.987056535354904 0.195607029693945 no 2708 0.161807461956217 4074 712797 YDL207W GLE1 SGTC_1104 tacrolimus 29.8 µM -0.98866921921671 0.195230534881499 no 2709 0.161412503732322 4110 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41 SGTC_335 4077-0256 27.6 µM -0.990192691248589 0.194875272122129 no 2710 0.161039972120703 4065 3121989 SGTC_1800 st050079 29.0735 µM -0.99085252776738 0.19472152506783 no 2711 0.160878797874868 3946 3645560 SGTC_1402 3909-7673 35.9 µM -0.993550683304071 0.194093601972593 no 2712 0.160220831957244 4079 5328014 SGTC_3149 9097855 49.47 µM -0.993660715533468 0.194068021137594 no 2713 0.160194037135745 4084 25236625 YMR079W SEC14 SGTC_2600 tangeritin 87.95 µM -0.993947976768966 0.194001246911358 no 2714 0.160124097679465 4019 68077 A bioactive flavone. SGTC_2551 apiole 73.87 µM -0.995748854671393 0.193582949702774 no 2715 0.159686093116157 3954 10659 A possible DNA adduct former. SGTC_209 4077-0173 175.592 µM -0.997136143652734 0.193261093848496 no 2716 0.159349215607767 4062 15993494 SGTC_99 0109-0120 622.8 µM -0.99788260068499 0.193088048451449 no 2717 0.159168145000737 4069 759414 SGTC_564 3555-0129 330 µM -0.999739372120345 0.192658017900221 no 2718 0.158718326466487 3922 563260 SGTC_490 phenamil 164 µM -1.00342861040735 0.191805324288473 no 2719 0.157827052811929 4064 4755 Irreversibly blocks amiloride-sensitive Na+ channels. SGTC_2036 5160441 105 µM -1.00511069278892 0.191417312739472 no 2720 0.157421775919335 4063 134534 YIL048W NEO1 SGTC_2353 9059630 146.67 µM -1.00600820732327 0.191210477002193 no 2721 0.157205811022922 4132 4779114 SGTC_504 lovastatin 124 µM -1.00857463784002 0.190619789518445 no 2722 0.156589337869874 4113 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1 SGTC_2252 omeprazole 400 µM -1.00858818381896 0.190616674761992 no 2723 0.156586088266397 4048 4594 A proton pump inhibitor. SGTC_2360 9040895 200 µM -1.01470981868728 0.189212267510171 no 2724 0.15512208616823 4132 4914414 SGTC_1355 1499-0035 1.68 µM -1.01481548101861 0.189188082839784 no 2725 0.155096896389533 4097 1548538 SGTC_324 1315-0088 19.6 µM -1.01516647873666 0.189107757901 no 2726 0.155013238323856 4069 6787421 SGTC_790 1575-0012 79.1 µM -1.0171114738904 0.18866303145351 no 2727 0.154550201295041 4172 378741 YLR208W SEC13 SGTC_247 mechlorethamine 29.705 µM -1.01826057294496 0.188400591228521 no 2728 0.15427707002258 4009 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links. SGTC_1405 3909-7894 12 µM -1.01862126310638 0.188318260444836 no 2729 0.154191402839322 4109 7104060 SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM -1.01919551884495 0.18818722719882 no 2730 0.154055076829618 4163 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_3159 9100096 49.47 µM -1.02060803114885 0.1878651606674 no 2731 0.153720091469904 4051 25236875 SGTC_1100 amiodarone 5.07 µM -1.02113538690689 0.187745005740589 no 2732 0.15359514975752 4202 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. SGTC_1875 nocodazole 6 µM -1.02210628239059 0.187523917055188 no 2733 0.153365300031944 4130 4122 A microtubule depolymerizer. YJL014W CCT3 SGTC_841 0251-0215 91.2 µM -1.02252897520394 0.187427713321318 no 2734 0.153265302999929 4136 3888614 SGTC_2331 7980721 200 µM -1.0229114521721 0.187340688899732 no 2735 0.153174857126616 4086 2981221 SGTC_393 acivicin 6.25 µM -1.02454854952925 0.186968484900701 no 2736 0.152788125893633 3968 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1 SGTC_2236 dapsone 200 µM -1.02534905780805 0.186786651169788 no 2737 0.152599257901351 4112 2955 A bacterial DFR inhibitor. An anti-cancer agent. SGTC_382 3229-0966 23.2 µM -1.0279224477343 0.186202853050721 no 2738 0.151993154655995 4156 5722370 SGTC_256 clotrimazole 625 nM -1.02839251400982 0.18609633628964 no 2739 0.151882614234319 4049 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C SGTC_2642 cholecalciferol 100 µM -1.03121555166557 0.185457432338437 no 2740 0.151219874681983 4120 9821465 A vitamin D precursor, similar to steriods. SGTC_2439 5492030 7.2 µM -1.03132260425418 0.185433231245823 no 2741 0.151194780809119 4123 5722370 SGTC_2765 myclobutanil 7.74 µM -1.03361221367105 0.184916094783634 no 2742 0.150658743627367 4155 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11 SGTC_1346 1488-2224 62.4 µM -1.0343485762484 0.18474996888292 no 2743 0.15048661769575 4140 3722427 SGTC_749 1000-0129 128 µM -1.03599562995832 0.18437872394414 no 2744 0.150102090631834 4184 708470 SGTC_999 SEC7.066 22.7 µM -1.0366396461757 0.184233689371074 no 2745 0.149951914584824 4093 740511 YDR170C SEC7 SGTC_3107 9121808 49.47 µM -1.03689097450631 0.184177108668833 no 2746 0.149893335337827 4015 662681 SGTC_1234 0326-0494 15.5 µM -1.03729581809524 0.184085990337601 no 2747 0.149799007070591 4209 1547813 SGTC_978 1416-0512 87.4 µM -1.03881930857587 0.183743349211339 no 2748 0.149444389808844 4216 6814003 SGTC_1855 st056195 39.6 µM -1.03990255774996 0.183499962548323 no 2749 0.149192587020747 4090 4028379 SGTC_955 1216-0110 33 µM -1.04076306202378 0.183306765954076 no 2750 0.148992763641228 4116 3619719 SGTC_1244 0416-0015 52.5 µM -1.04285425814382 0.18283778879635 no 2751 0.148507898725567 4106 96201 SGTC_2371 9071574 200 µM -1.0444068361939 0.182490088414165 no 2752 0.148148601057959 4142 45596039 SGTC_534 k292-0788 63.4 µM -1.04763982908473 0.181767385105756 no 2753 0.147402289851257 4191 4146317 SGTC_958 1222-0007 33 µM -1.0476752867216 0.181759468843968 no 2754 0.147394118723433 4225 7312461 SGTC_1634 st006576 41 µM -1.04932293276599 0.181391853761032 no 2755 0.147014757368108 4143 3915356 SGTC_2766 oltipraz 83.91 µM -1.05018226455819 0.181200308504779 no 2756 0.146817161018368 4116 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40 SGTC_1503 4585-0012 61.3 µM -1.05064682501979 0.18109681064615 no 2757 0.146710413348443 4200 2922052 SGTC_2408 sulbentine 18.36 µM -1.05081172735283 0.181060081519351 no 2758 0.146672534273828 4090 67686 An antifungal agent of unknown mechanism. YDL205C HEM3 SGTC_1132 3456-3614 2.5 µM -1.05088739807351 0.181043228744655 no 2759 0.146655154443284 4211 3125502 SGTC_2289 7946404 165.07 µM -1.05147522410528 0.180912346329034 no 2760 0.14652019133978 4157 1246120 YPR165W RHO1 SGTC_1296 1068-0102 11.9 µM -1.05349612717592 0.180462834650101 no 2761 0.146056834165425 4155 767053 SGTC_1821 st053465 65.6 µM -1.0558059965456 0.179949906767783 no 2762 0.145528429018802 4159 675086 SGTC_1920 st075728 45.7 µM -1.05720113447763 0.179640547401568 no 2763 0.145209901093215 4125 3400306 SGTC_1814 st052110 31.539 µM -1.06116842664537 0.178762663622859 no 2764 0.144306682666351 4107 674163 SGTC_366 0181-0206 4.31 µM -1.06274035373094 0.178415575393823 no 2765 0.143949857652185 4187 274874 SGTC_2920 7982904 15.77 µM -1.06640430144748 0.177608209515574 no 2766 0.143120459037775 4170 6456808 SGTC_2821 7996764 71.43 µM -1.06748243226963 0.177371078687032 no 2767 0.142877021230105 4217 2987135 SGTC_763 3453-1109 128 µM -1.0688106494191 0.177079217270883 no 2768 0.142577499852208 4168 1560353 SGTC_65 0798-0905 34.986 µM -1.07071851826067 0.176660514881393 no 2769 0.142148006843044 4271 3602145 SGTC_2794 7785382 27.27 µM -1.07500652950309 0.175721751346869 no 2770 0.141185902499978 4148 2205081 SGTC_1618 st003135 44.5 µM -1.07666109092814 0.175360368934147 no 2771 0.140815850497175 4132 1270615 SGTC_2226 7298446 200 µM -1.07696369675624 0.175294326035459 no 2772 0.140748242244075 4156 3283010 SGTC_3217 9129673 49.47 µM -1.07710425539342 0.175263654860309 no 2773 0.140716846098835 4207 17248312 SGTC_1278 0874-0585 172 µM -1.07878337382379 0.174897519105102 no 2774 0.140342154140883 4240 766306 SGTC_2848 9016370 25.97 µM -1.08007331338857 0.174616574654862 no 2775 0.14005476725253 4167 7894410 SGTC_1975 st070967 30.8 µM -1.08219005050163 0.174156177830287 no 2776 0.139584044292408 4169 261391 SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -1.08424892825419 0.173709106487049 no 2777 0.139127221478783 4172 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. SGTC_804 1595-0054 20.9 µM -1.08491921007275 0.173563717011352 no 2778 0.138978719480111 4122 761523 Stimulates phospholipase C. SGTC_1712 st032288 53.4 µM -1.08500212294464 0.173545737931087 no 2779 0.138960357504876 4051 2883011 SGTC_1976 st070609 63.5 µM -1.08645795551976 0.173230243874103 no 2780 0.138638216337952 4091 682556 SGTC_326 k292-0812 17.5 µM -1.08682766363508 0.173150182469445 no 2781 0.138556489782365 4163 3579357 SGTC_533 1222-0222 6.71 µM -1.09210605532968 0.172009701806074 no 2782 0.137393244085066 4216 3982874 SGTC_2272 7805186 180 µM -1.09214499804806 0.172001305471299 no 2783 0.137384686789592 4194 2956062 YPR165W RHO1 SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -1.09282222640357 0.171855331928025 no 2784 0.137235930434015 4190 688751 SGTC_2617 dihydrotanshinone i 20.83 µM -1.09321269810018 0.171771203467132 no 2785 0.137150211531412 4161 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12 SGTC_764 1951-2361 146 µM -1.09436058108401 0.171524040509405 no 2786 0.136898432583351 4189 5438930 SGTC_1220 1838-0075 193 µM -1.09777588348956 0.170790000030938 no 2787 0.136151182360068 4090 5529645 SGTC_1265 0819-1001 68.8 µM -1.0983965421617 0.17065681994952 no 2788 0.136015685821653 4151 3106768 SGTC_296 1222-0039 74.9 µM -1.09866236857364 0.170599799624728 no 2789 0.135957681269416 4192 5984176 SGTC_2110 5483698 200 µM -1.09879640485429 0.170571053186649 no 2790 0.135928440356709 4164 2848765 YHR062C RPP1 SGTC_2222 6885208 172.143 µM -1.10345516684447 0.169573827302122 no 2791 0.134914775427176 4156 609514 SGTC_1066 ketoconazole 628 nM -1.10373278076385 0.169514521297399 no 2792 0.134854535642609 4263 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W SGTC_2130 NSC 7 2.4545 µM -1.10408731066943 0.169438803265072 no 2793 0.13477763259737 4269 21448 SGTC_960 1222-0186 7.7 µM -1.10756728958368 0.168696725954302 no 2794 0.134024368356283 4232 3126296 SGTC_2905 7799065 20.05 µM -1.11004139923835 0.168170414484345 no 2795 0.133490593643899 4109 1296806 SGTC_3259 9138485 49.47 µM -1.11208348945175 0.167736802206495 no 2796 0.133051127444773 4222 17646153 SGTC_1553 gossypol 38.6 µM -1.11688793148668 0.166719481350396 no 2797 0.13202112269453 4094 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_360 0957-0399 1.01 µM -1.11944482328413 0.166179696676838 no 2798 0.131475208849993 4217 6752301 YPR165W RHO1 SGTC_663 1486-0733 13.9 µM -1.12058385065243 0.165939600820031 no 2799 0.131232521154128 4229 722445 YPR165W RHO1 SGTC_1604 st002052 72.4 µM -1.12115420347168 0.165819460287399 no 2800 0.131111114834583 4300 6254834 YHR062C RPP1 SGTC_1594 piperine 70.1 µM -1.12292891695436 0.165445990017052 no 2801 0.130733842560186 4184 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation. SGTC_817 1391-0715 46 µM -1.12330277741297 0.165367384357427 no 2802 0.130654462318844 4204 1353946 SGTC_1023 4482-3888 16 µM -1.12332393253065 0.165362937131624 no 2803 0.130649971536774 4226 3303168 SGTC_2196 6573537 42.6665 µM -1.12574737379371 0.164853993865001 no 2804 0.130136232650764 4228 2903087 SGTC_198 3454-2873 16.191 µM -1.12625080040767 0.164748397395229 no 2805 0.130029688181766 4202 710957 SGTC_3201 9113999 49.47 µM -1.12675870376532 0.16464190631829 no 2806 0.129922257461189 4230 16649224 SGTC_1406 3909-7906 11.9 µM -1.12691861387206 0.164608387521279 no 2807 0.129888446311853 4231 X1406 SGTC_774 k060-0086 136 µM -1.12804742972895 0.16437190194133 no 2808 0.129649944490507 4233 5911235 SGTC_2744 captopril 92.04 µM -1.12850274715955 0.164276575851819 no 2809 0.129553828667209 4268 44093 angiotensin-converting enzyme (ACE) inhibitor  SGTC_1085 doxorubicin 7.67 µM -1.13016687688254 0.16392847561426 no 2810 0.129202957006842 4245 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2 SGTC_2616 abietic acid 100 µM -1.13240884949692 0.163460260381966 no 2811 0.128731293039031 4270 6708678 Abietic acid is an inhibitor of 5α-reductase. SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.13280133560479 0.163378382714942 no 2812 0.128648845230984 4258 6728940 SGTC_1715 st032160 10.2275 µM -1.13363928434157 0.163203664967928 no 2813 0.128472943715913 4166 5289825 SGTC_2047 4141938 200 µM -1.13431646682519 0.163062556768053 no 2814 0.128330912147573 4229 3807862 SGTC_1993 st073995 70.8 µM -1.13461549281406 0.163000272343153 no 2815 0.128268229451675 4209 3098394 SGTC_2048 5246248 200 µM -1.13546542520673 0.162823323531503 no 2816 0.128090180261401 4259 677046 SGTC_1705 st027868 56.3335 µM -1.13869106517999 0.162152909399118 no 2817 0.127416015336407 4167 292948 SGTC_2976 9009005 19.48 µM -1.14039423369748 0.161799650518207 no 2818 0.127061047065764 4271 2993148 SGTC_844 0330-0132 15.3 µM -1.14047002450077 0.161783942201944 no 2819 0.127045267028087 4278 2828079 SGTC_2689 tacrolimus 100 µM -1.14082536453048 0.16171030808143 no 2820 0.126971301581357 4257 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). SGTC_3339 9145883 14.936 µM -1.14302079822945 0.16125585130154 no 2821 0.126514977958566 4130 2030670 SGTC_1410 3909-8106 77.9 µM -1.14685930040139 0.160463281557737 no 2822 0.125719887963579 4285 1039210 SGTC_367 0335-0881 7.1 µM -1.14718537419974 0.160396071678019 no 2823 0.125652507502689 4198 23828853 SGTC_2145 5634607 200 µM -1.15247042331152 0.159309290353218 no 2824 0.124563908386389 4211 308662 SGTC_794 k038-0031 316 µM -1.15334808831304 0.159129281293077 no 2825 0.124383769782735 4230 6624242 SGTC_2043 5101342 149 µM -1.15667607106684 0.158447923114977 no 2826 0.123702364819818 4257 678451 SGTC_2937 9044753 11.33 µM -1.16026077558048 0.157716148692576 no 2827 0.122971324633501 4183 6465530 YGL099W LSG1 SGTC_1632 st005650 90 µM -1.1609495529139 0.157575797731145 no 2828 0.122831207695523 4280 2759605 SGTC_1979 st071809 45.3 µM -1.16386001298206 0.156983644650869 no 2829 0.122240373400317 4323 4976333 SGTC_1246 0422-0085 105 µM -1.16503143321275 0.156745724851776 no 2830 0.122003134718613 4288 264295 SGTC_991 3996-0057 64.7 µM -1.165492486404 0.156652148352745 no 2831 0.12190984991937 4309 715343 SGTC_1989 st071868 50.2 µM -1.16658227515366 0.156431108342345 no 2832 0.121689552388283 4248 16414057 SGTC_1691 st019933 84.6 µM -1.16665306484782 0.156416757295997 no 2833 0.12167525214571 4253 6176082 SGTC_1873 rapamycin 2 nM -1.16702176956215 0.156342024580779 no 2834 0.121600789114172 4208 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1 SGTC_2912 7964298 10.93 µM -1.16802854883933 0.156138080410149 no 2835 0.121397624681637 4262 2975850 SGTC_3055 9094636 49.47 µM -1.1682588770576 0.156091447269409 no 2836 0.121351178840449 4292 25236176 SGTC_670 4204-0025 119 µM -1.16933415383358 0.155873864030425 no 2837 0.121134513877555 4274 719039 SGTC_2163 5671233 125 µM -1.17105206963239 0.155526657305785 no 2838 0.120788924035943 4224 701023 SGTC_2815 7968870 71.43 µM -1.17152200307834 0.155431768336687 no 2839 0.120694509420123 4213 2977326 YHR190W ERG9 SGTC_896 0964-0007 44.5 µM -1.17265588777571 0.155202971632257 no 2840 0.120466913895177 4221 6756758 SGTC_610 4215-0184 155 µM -1.17433163266507 0.154865244956887 no 2841 0.120131108851724 4275 5605015 SGTC_39 0986-0283 58.349 µM -1.17678113387995 0.1543724508412 no 2842 0.119641437304673 4339 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2 SGTC_2465 5809242 33.21 µM -1.17702986856438 0.154322468096451 no 2843 0.119591792438122 4311 2731748 SGTC_2066 5222451 176 µM -1.17818488688739 0.154090509674103 no 2844 0.119361453145513 4229 2281147 SGTC_1209 2323-2347 50.3 µM -1.17866700799658 0.153993755189139 no 2845 0.11926539891241 4272 5412760 SGTC_881 0833-0569 170 µM -1.1812351812435 0.153479038789682 no 2846 0.118754654441583 4284 5418700 SGTC_1829 berberine 14.4 µM -1.18146287829694 0.153433458525659 no 2847 0.118709445959089 4237 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid. SGTC_2770 toltrazuril 17.5 µM -1.18333138542526 0.153059760566661 no 2848 0.118338919409899 4215 68591 Kills coccidiodes. SGTC_1323 1348-1351 11.2 µM -1.18618192221164 0.152490821705765 no 2849 0.11777523189819 4243 6989654 SGTC_803 4488-1585 147 µM -1.18716393353902 0.152295147409975 no 2850 0.117581482026184 4260 747204 SGTC_1389 3405-0187 19 µM -1.18725598838429 0.152276813230244 no 2851 0.117563331269238 4239 799890 SGTC_1347 1493-0251 600 nM -1.19031996034056 0.151667410730778 no 2852 0.116960329227553 4321 3986378 SGTC_2313 7726885 200 µM -1.19093037207649 0.151546198022277 no 2853 0.116840460040956 4288 726423 SGTC_1227 3909-8010 46.6 µM -1.19291173671193 0.151153191799692 no 2854 0.116451971088978 4263 15982272 SGTC_1403 3909-7815 62.9 µM -1.19373316149493 0.150990460140652 no 2855 0.116291182141841 4243 6615483 SGTC_1555 citronellol 128 µM -1.19458447743071 0.150821929855937 no 2856 0.116124708473524 4241 8842 A terpine precursor. SGTC_622 1348-1566 26.3 µM -1.19593364946465 0.150555098353624 no 2857 0.115861226287621 4274 7340407 SGTC_1774 st048371 48.465 µM -1.19748840839109 0.150247997238109 no 2858 0.11555812147913 4265 4242727 SGTC_3176 9106582 49.47 µM -1.1996795162319 0.14981591162212 no 2859 0.115131915667682 4256 17018027 SGTC_1054 3429-0080 167 µM -1.19983567517032 0.149785148811749 no 2860 0.115101582958305 4313 1162877 SGTC_1480 1070-0044 41.2 µM -1.2002749258559 0.149698640431238 no 2861 0.115016292260484 4313 3124987 SGTC_1978 st071761 42 µM -1.20299701714386 0.149163280672502 no 2862 0.114488737421771 4314 5147680 SGTC_1619 st003326 88.7 µM -1.20306629754375 0.149149671848364 no 2863 0.114475333049818 4276 2849032 SGTC_3353 9151644 39.2805 µM -1.20307173574445 0.149148603651798 no 2864 0.11447428091402 4308 4909158 SGTC_252 miconazole 1.30953 nM -1.20412689577951 0.148941440900746 no 2865 0.114270267946611 4186 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W SGTC_939 1165-0479 45.3 µM -1.20531835602133 0.148707749129057 no 2866 0.114040213013821 4282 1377347 SGTC_2605 digitonin 300 nM -1.20589810590645 0.148594126281099 no 2867 0.11392839053002 4305 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. SGTC_1112 tnp00069 1.16933 µM -1.20621589640021 0.148531868434986 no 2868 0.11386712808182 4297 145826 SGTC_650 1328-0195 38 µM -1.20628132805655 0.148519051985575 no 2869 0.1138545173297 4289 2780821 SGTC_1288 0973-0013 65.5 µM -1.21299874028002 0.147207210816696 no 2870 0.112565151069912 4322 4315430 SGTC_1659 st012954 42.1 µM -1.22011557649112 0.145825864901593 no 2871 0.111210532259144 4250 24207262 SGTC_3305 9127027 53.8275 µM -1.2203554203856 0.145779464526728 no 2872 0.111165084550514 4244 41905295 SGTC_2067 5224629 34.075 µM -1.22043123964994 0.145764798541166 no 2873 0.111150720423277 4295 2835000 SGTC_1216 1165-0504 9.65 µM -1.22046432197886 0.145758399621335 no 2874 0.111144453319413 4309 6304004 SGTC_990 3985-0011 41.3 µM -1.22209788906838 0.145442663224236 no 2875 0.110835305651226 4283 5399565 YGL099W LSG1 SGTC_1435 4092-0789 56.7 µM -1.22422976691859 0.145031305534794 no 2876 0.11043278146872 4286 2248285 SGTC_1140 3229-1848 2.98 µM -1.22531054307982 0.144823063195637 no 2877 0.110229118756378 4321 2849525 SGTC_1880 MG-132 525 µM -1.22653007520854 0.144588327453328 no 2878 0.109999632358579 4260 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1 SGTC_3078 9116413 49.47 µM -1.22707563886388 0.14448340029784 no 2879 0.109897081553177 4236 17177322 SGTC_2482 5981709 142.65 µM -1.22856525480745 0.144197166826851 no 2880 0.109617424624107 4235 877755 SGTC_266 formosanin C 406 nM -1.23048912454208 0.143828056458106 no 2881 0.109256998534403 4158 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1 SGTC_3282 9108498 15.4605 µM -1.23128449108099 0.14367564518924 no 2882 0.109108240154668 4283 16459645 SGTC_2448 5185112 27.17 µM -1.23268520246185 0.143407500430586 no 2883 0.108846617375135 4323 5718189 SGTC_402 epigallocatechin gallate 10 µM -1.23287096931925 0.143371963602778 no 2884 0.108811954022957 4258 65064 An antioxidant. SGTC_1345 1488-0192 31.4 µM -1.23298795446352 0.143349587630528 no 2885 0.108790129136641 4362 658348 SGTC_1643 st009866 20.2 µM -1.23336874169212 0.143276770060011 no 2886 0.108719110820692 4265 3156273 YOR207C RET1 SGTC_2425 5628681 7.85 µM -1.23558518578915 0.142853417546541 no 2887 0.108306397043355 4381 5714958 SGTC_3044 9093193 49.47 µM -1.23723583534114 0.14253868460191 no 2888 0.107999770600307 4340 25236277 SGTC_451 chloral hydrate 100 µM -1.23745210609205 0.142497482560006 no 2889 0.107959642272417 4329 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1 SGTC_718 1130-0073 349 µM -1.23943194334741 0.142120675411653 no 2890 0.107592788930193 4343 6740020 SGTC_3344 9148862 3.898 µM -1.24088662465541 0.141844247302896 no 2891 0.1073238172455 4351 4905352 SGTC_156 3474-0145 5.642 µM -1.24221513018285 0.141592114234925 no 2892 0.107078599360501 4229 2265471 SGTC_3133 9127736 49.47 µM -1.2475770730945 0.140577574328042 no 2893 0.106092989452647 4338 27243420 SGTC_2742 clothiapine 36.27 µM -1.2526858386292 0.139615539449463 no 2894 0.105160030853399 4363 16351 An atypical antipsychotic. YIL048W NEO1 SGTC_2916 7875993 68.79 µM -1.25293484706342 0.139568763212704 no 2895 0.105114709361312 4171 1299250 SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -1.25333579199816 0.139493468101405 no 2896 0.105041763940303 4349 5269 Sir2p (silent information regulator) and HDAC inhibitor. SGTC_201 4262-0159 12.803 µM -1.25431908881717 0.13930892769738 no 2897 0.10486302418062 4362 1341029 SGTC_399 oxolinic acid 75 µM -1.25954869800389 0.138330251476897 no 2898 0.103916106133129 4315 4628 A DNA gyrase inhibitor. SGTC_2833 9001315 45.46 µM -1.25983157488676 0.13827744744811 no 2899 0.10386506337843 4287 2989378 SGTC_245 methotrexate 289.6 µM -1.26083394798363 0.138090447206891 no 2900 0.103684339972006 4291 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2 SGTC_1903 st060211 78.3 µM -1.26432838179736 0.137439883278476 no 2901 0.103056093341743 4363 688960 SGTC_2809 7964133 12.99 µM -1.26486174301767 0.137340771006304 no 2902 0.102960446751763 4333 1253665 SGTC_1200 1643-0193 18.4 µM -1.26585229279763 0.137156830830303 no 2903 0.10278298458836 4350 5403974 SGTC_1592 4',5'-dihydroxyflavone 8.85 µM -1.26718159065188 0.13691025138313 no 2904 0.102545183376087 4333 688669 SGTC_2473 5854593 8.94 µM -1.2679127127193 0.136774760376823 no 2905 0.102414561850743 4246 2872951 SGTC_2143 5623677 140.463 µM -1.27716966939337 0.135067194372821 no 2906 0.100771176292983 4278 5375313 SGTC_1983 st071813 46.9 µM -1.28089379304142 0.134384372715683 no 2907 0.100115486637785 4413 11838595 SGTC_1698 5-fluorocytosine 1.055 µM -1.28213537531351 0.134157255155707 no 2908 0.0998975806841483 4366 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU. SGTC_2128 5255449 168.493 µM -1.28721136509708 0.133231468533451 no 2909 0.0990103135107405 4291 736008 SGTC_1263 0774-1208 64.8 µM -1.28747012523301 0.133184392501744 no 2910 0.0989652379644753 4383 906585 SGTC_2564 betulinic acid 100 µM -1.28998838417096 0.13272684535968 no 2911 0.0985273455988776 4395 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14 SGTC_2329 6138490 200 µM -1.29126868760175 0.132494640251493 no 2912 0.0983052622209605 4406 720019 SGTC_3204 9114183 49.47 µM -1.29642677871444 0.13156196788883 no 2913 0.0974142455957417 4331 17027248 SGTC_2220 6782180 200 µM -1.29679696096082 0.131495207229103 no 2914 0.0973505283192475 4284 833803 SGTC_1859 st055998 20 µM -1.3000152484157 0.13091578934008 no 2915 0.0967978715119802 4312 676301 SGTC_768 0384-0033 77.3 µM -1.3007025700033 0.130792273498875 no 2916 0.0966801411289054 4319 3965305 YMR134W ERG29 SGTC_2055 5235184 200 µM -1.30254432267806 0.130461696599814 no 2917 0.0963651883546032 4398 2836034 SGTC_2444 5485484 36.41 µM -1.30699312669081 0.129665564270016 no 2918 0.0956075229181806 4431 6790631 SGTC_1795 st049545 62.3 µM -1.30796602754042 0.129491908895077 no 2919 0.095442416165978 4315 5291882 SGTC_1369 1866-0067 208 µM -1.3084092909875 0.129412843208374 no 2920 0.0953672614943243 4388 3531355 SGTC_32 0928-0142 34.1 µM -1.30873162751826 0.129355368482283 no 2921 0.0953126371706107 4350 2244242 SGTC_1177 0983-0204 23.6 µM -1.30959342070443 0.129201791960944 no 2922 0.0951667076820089 4396 766818 SGTC_1587 estradiol valerate 56.1 µM -1.31224396844003 0.128730241422891 no 2923 0.0947189154506586 4425 13791 A steroid. SGTC_1075 aripiprazole 15.2 µM -1.31455544894243 0.128319989079384 no 2924 0.0943296755988808 4432 60795 An atypical antipschotic. YIL048W NEO1 SGTC_2595 hexamethylquercetagetin 100 µM -1.31545802450982 0.128160042461264 no 2925 0.094178007806793 4378 386331 SGTC_2003 4023581 200 µM -1.31639525132596 0.12799410184695 no 2926 0.0940207077211313 4397 16641307 SGTC_3200 9114385 49.47 µM -1.32094466676304 0.127190726642092 no 2927 0.0932599074239241 4380 17018030 YLR208W SEC13 SGTC_815 1582-0027 36.9 µM -1.32240241884709 0.126934047924851 no 2928 0.0930170919190473 4399 3128206 SGTC_2847 9005661 71.43 µM -1.32287641631592 0.126850664922299 no 2929 0.0929382396617302 4426 2991449 SGTC_2875 9039966 71.43 µM -1.32299254973524 0.126830241193381 no 2930 0.0929189277259149 4372 6463691 SGTC_658 3253-0951 102 µM -1.32349674812448 0.126741597215162 no 2931 0.092835118500127 4383 1184878 SGTC_865 0488-0499 301 µM -1.32352205644195 0.126737148854081 no 2932 0.0928309131565649 4334 9634651 SGTC_1434 4073-0095 163 µM -1.32412040870205 0.126632010081749 no 2933 0.0927315292897961 4376 24133745 SGTC_248 streptozotocin 5.23457 mM -1.32506640791579 0.126465908896539 no 2934 0.0925745632642439 4411 5300 DNA alkylating agent. SGTC_1756 st041558 35.5 µM -1.32630136475893 0.126249300219728 no 2935 0.0923699474927028 4463 3955792 SGTC_2778 tioconazole 65.09 nM -1.32780641152262 0.125985668124898 no 2936 0.0921210341594799 4277 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_608 k048-0125 159 µM -1.33257923337398 0.125152174726845 no 2937 0.0913349619036792 4432 6817652 YLR060W | YFL022C FRS1 | FRS2 SGTC_2950 9072895 21.46 µM -1.33708950336071 0.124368077599786 no 2938 0.0905967115286097 4356 17332245 SGTC_2149 5554786 194.827 µM -1.339347345092 0.123976851494383 no 2939 0.090228811216993 4427 745063 YPR165W RHO1 SGTC_2968 9090663 33.37 µM -1.34291154338688 0.123361021626835 no 2940 0.0896503090909312 4343 25236811 SGTC_1011 4112-3381 17.4 µM -1.34470321939956 0.123052262749496 no 2941 0.0893605472880412 4444 2877139 SGTC_996 3970-0799 1.8 µM -1.34528183839149 0.122952665369488 no 2942 0.0892671181522814 4377 6615648 YGL040C HEM2 SGTC_1780 st038448 24.544 µM -1.35162833053342 0.121863955839497 no 2943 0.0882471213172116 4426 728868 YDL195W SEC31 SGTC_1084 voriconazole 435 nM -1.35343056687193 0.121556029421865 no 2944 0.0879590588930401 4420 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C SGTC_1254 0550-0035 264 µM -1.35469879607113 0.121339670464583 no 2945 0.0877567708136612 4407 15121435 SGTC_857 0438-0306 1.35 µM -1.35596178698723 0.121124474406221 no 2946 0.0875556633615444 4465 4686136 SGTC_109 0132-0036 33.701 µM -1.35652674275809 0.121028300766446 no 2947 0.0874658162314754 4279 67274 A color developer. SGTC_1467 k284-1082 293 µM -1.35727543456034 0.120900932138409 no 2948 0.0873468548846082 4379 3334705 SGTC_2891 9063876 19.48 µM -1.36152974539974 0.120178972911252 no 2949 0.0866731700019354 4437 6472478 SGTC_1009 4106-0057 9.87 µM -1.36214940138722 0.120074070885095 no 2950 0.0865753702115448 4409 2928005 SGTC_213 1246-0773 967 nM -1.36255148689216 0.120006036061243 no 2951 0.08651195353454 4433 6251622 SGTC_1314 1222-0010 41.1 µM -1.36571611598955 0.119471513820916 no 2952 0.0860140419845466 4417 3526027 SGTC_897 1000-0139 31.4 µM -1.36609643556973 0.119407389115131 no 2953 0.0859543484691503 4381 6151020 SGTC_1799 st045822 46.1415 µM -1.37040061261377 0.118683365209465 no 2954 0.0852809404844774 4399 3674992 SGTC_2308 7584454 197.62 µM -1.37137638171898 0.118519659131484 no 2955 0.085128828064629 4433 893577 SGTC_971 1315-0384 26.7 µM -1.37145762768377 0.118506035588585 no 2956 0.0851161718252826 4447 6769120 SGTC_694 1315-0438 43.2 µM -1.3723649367074 0.118353970748634 no 2957 0.084974929883983 4428 6793154 SGTC_621 3584-0052 32.1 µM -1.3744310911571 0.118008198476935 no 2958 0.0846539446966058 4442 2273927 SGTC_2713 st079149 53.4 µM -1.37487482794765 0.117934032146233 no 2959 0.0845851272245453 4460 3103253 SGTC_189 3970-0742 2.116 µM -1.37687059312204 0.117600866928162 no 2960 0.0842761302273442 4388 2891807 SGTC_48 0382-0018 55 µM -1.37989482897887 0.117097283502143 no 2961 0.0838095144885025 4463 762596 SGTC_1656 st012921 11 µM -1.38473832915277 0.116293949983583 no 2962 0.083066247209528 4328 6732821 SGTC_722 3534-0461 190 µM -1.38776695080598 0.115793620073992 no 2963 0.0826040107750078 4445 658262 SGTC_2489 cantharidin 73.42 µM -1.39065690472545 0.115317625253183 no 2964 0.0821647458361393 4388 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7 SGTC_1813 st051246 8.6015 µM -1.39346852309238 0.114855869147664 no 2965 0.0817390785580261 4373 5291959 SGTC_1603 st002045 67.8 µM -1.39394410792774 0.114777893408265 no 2966 0.0816672416697961 4418 5887985 SGTC_2504 purpurogallin 52.29 µM -1.3983767840248 0.114052933598253 no 2967 0.0809999755048173 4350 5281571 An antioxidant. SGTC_2158 5657123 3.6195 µM -1.3987470736142 0.113992521060946 no 2968 0.0809444213053351 4424 2858827 SGTC_507 nimesulide 162 µM -1.39979157055509 0.113822234839046 no 2969 0.0807878713997483 4476 4495 A COX2 inhibitor. SGTC_2271 7849410 118.62 µM -1.40288789610252 0.113318500788698 no 2970 0.0803251353947684 4358 972430 SGTC_674 0498-0004 451 µM -1.40352201808859 0.113215533432689 no 2971 0.0802306154611317 4429 4231473 SGTC_705 1124-0212 310 µM -1.40463523130027 0.113034933762004 no 2972 0.0800648872734728 4429 9554485 SGTC_2738 aclarubicin 5.55 µM -1.40758377909619 0.112557576400502 no 2973 0.0796271766977158 4475 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31 SGTC_1276 0871-0068 94.2 µM -1.40845078811381 0.112417485668671 no 2974 0.0794988146794277 4460 3414906 SGTC_24 0417-1663 219 µM -1.40846396285611 0.112415357863981 no 2975 0.0794968653471117 4468 4329390 SGTC_2545 solidagenone 89.61 µM -1.41098104916022 0.112009360170871 no 2976 0.0791251009775241 4343 6708572 An anti ulcer agent SGTC_662 k832-1615 104 µM -1.4127148898061 0.111730307873175 no 2977 0.0788697858694718 4458 5878478 SGTC_3038 9091290 49.47 µM -1.4148875623586 0.111381330436048 no 2978 0.0785507326281413 4446 25236843 SGTC_2588 indole-3-carbinol 100 µM -1.41521838571776 0.111328261682168 no 2979 0.0785022377306272 4443 3712 Induces cell cycle arrest. SGTC_1560 lithocholic acid 53.1 µM -1.41560061833547 0.111266968695182 no 2980 0.0784462350916716 4380 9903 A bile acid which acts as a detergent. SGTC_2625 euphol 100 µM -1.41649820121096 0.111123131600027 no 2981 0.0783148452241247 4443 6708538 A triterpene alcohol. SGTC_1291 0993-0025 5.79 µM -1.41734839756204 0.110987011003391 no 2982 0.0781905458450601 4434 4353356 SGTC_2747 doxorubicin 7.63 µM -1.41837799284714 0.110822327702371 no 2983 0.0780402185974953 4490 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. SGTC_769 0302-0231 76 µM -1.42245096833598 0.110172573418727 no 2984 0.0774476879416534 4356 571869 YER009W NTF2 SGTC_1025 k007-0731 70 µM -1.42320321801342 0.110052867971043 no 2985 0.0773386265108167 4420 6256118 SGTC_1338 1486-1223 76 µM -1.4232348054113 0.110047843512448 no 2986 0.0773340495118806 4455 3444526 SGTC_2004 4023728 41.89 µM -1.42496881538636 0.109772275163844 no 2987 0.0770831078417133 4404 360084 YDR527W RBA50 SGTC_3314 9135860 59.4275 µM -1.42519665630298 0.109736103602617 no 2988 0.0770501813116293 4439 25252478 SGTC_2237 6667747 47.222 µM -1.42547655993781 0.1096916783831 no 2989 0.0770097455480881 4445 729940 YDL015C TSC13 SGTC_1161 k007-0610 110 µM -1.42560590594654 0.109671153448595 no 2990 0.0769910652644653 4390 5843850 SGTC_3267 9137951 49.47 µM -1.42571030053133 0.109654589876628 no 2991 0.0769759910028929 4489 16643986 SGTC_2691 st077356 60.2 µM -1.42737494280887 0.109390715133787 no 2992 0.0767359246893539 4448 2839272 SGTC_1333 1482-0047 286 µM -1.43155637666589 0.108729897734841 no 2993 0.0761354108513354 4478 3811116 SGTC_3032 9089427 49.47 µM -1.43333682891802 0.108449395185279 no 2994 0.0758808009293976 4440 17173707 SGTC_2913 7966556 36.57 µM -1.43434434729757 0.10829089588378 no 2995 0.0757370103930671 4353 2976516 SGTC_543 3844-1095 191 µM -1.43560835915645 0.108092281783397 no 2996 0.0755569073899373 4470 4230703 SGTC_2279 7948423 32.93 µM -1.4361838008827 0.108001949586493 no 2997 0.0754750236307583 4412 1247112 SGTC_2141 5621638 7.665 µM -1.4368750608103 0.107893508262061 no 2998 0.0753767486967644 4485 2856238 SGTC_1492 4158-0558 28.5 µM -1.43909099716786 0.107546412136579 no 2999 0.0750623712205728 4455 3967268 SGTC_1098 clofazimine 15.1 µM -1.44021072463169 0.107371328489964 no 3000 0.0749038949577071 4514 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2 SGTC_736 0958-0254 92.6 µM -1.44329205329404 0.106890584419876 no 3001 0.0744691087096443 4517 6812352 SGTC_2700 st077718 96.8 µM -1.44641419081937 0.106405059303841 no 3002 0.0740305319763685 4431 904970 SGTC_1658 st012944 20 µM -1.44781291296535 0.106188060630432 no 3003 0.0738346901968516 4301 24207260 SGTC_2125 5246583 200 µM -1.45037928588508 0.105790743544007 no 3004 0.0734763901046231 4462 835267 SGTC_1916 st067606 49.2 µM -1.45365232192452 0.105285583969214 no 3005 0.0730213614929824 4363 19590279 SGTC_1680 diphenhydramine 100 µM -1.45769971142364 0.104663327220001 no 3006 0.0724616657712723 4437 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1 SGTC_1507 4075-3230 155 µM -1.45958447363336 0.104374469473612 no 3007 0.0722021544834824 4432 659771 SGTC_2741 miltefosine 3.04 µM -1.46289052248646 0.10386918225881 no 3008 0.0717486688788226 4522 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis. SGTC_107 0358-0022 2.6945 µM -1.46614679371554 0.103373239566627 no 3009 0.0713041499904468 4496 521106 YGL093W | YPR107C SPC105 | YTH1 SGTC_400 oxethazaine 37.5 µM -1.4683297358144 0.103041732904113 no 3010 0.0710073387254457 4501 4621 A local anesthetic. SGTC_813 k007-0158 173 µM -1.47457275735322 0.102097916688879 no 3011 0.070163721777368 4480 6523916 SGTC_2098 5376439 882.5 nM -1.47828289599386 0.101540008292721 no 3012 0.0696660368981182 4528 2844116 SGTC_445 e6 berbamine 66 µM -1.47971168597442 0.101325748642977 no 3013 0.0694751028115394 4492 6610268 A calcium/calmodulin antagonist. SGTC_649 1123-0311 367 µM -1.47974769488075 0.101320353048582 no 3014 0.0694702960297462 4381 693629 YIL048W NEO1 SGTC_1086 cerivastatin 2.18 µM -1.48045675055427 0.101214150394383 no 3015 0.0693756972814577 4496 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7 SGTC_1222 0366-0074 1.18 µM -1.48857462995103 0.100004027380773 no 3016 0.0682997081972478 4502 286520 SGTC_924 2046-0044 21.3 µM -1.49519535373517 0.0990249327723143 no 3017 0.0674317328895294 4471 3623589 SGTC_2955 9076254 12.21 µM -1.49560709476503 0.098964275553862 no 3018 0.067378036613673 4413 16459619 SGTC_1495 4469-0029 237 µM -1.5014188990334 0.0981109850133953 no 3019 0.0666236243663061 4499 793680 SGTC_2431 5490079 200 µM -1.50494013621559 0.0975966253210299 no 3020 0.0661697340996315 4533 5722345 SGTC_920 mycophenolic acid 780.421 nM -1.5065275251335 0.0973653974931073 no 3021 0.0659659033133201 4474 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. SGTC_715 0868-0130 184 µM -1.50684166079426 0.0973196864340255 no 3022 0.0659256240340806 4542 2876258 SGTC_2174 5790901 200 µM -1.50933524545172 0.0969573939916914 no 3023 0.0656065660095268 4474 786020 SGTC_1818 st052136 56.3 µM -1.51526848580822 0.0960993372817696 no 3024 0.0648522128305314 4145 674169 SGTC_3237 9133362 49.47 µM -1.51783714692306 0.0957295978844402 no 3025 0.0645277290094514 4481 43845137 SGTC_2566 crystal violet carbinol 226 nM -1.52103958897242 0.0952700976292888 no 3026 0.0641249514341727 4465 68050 Cationic dye that binds acidic phospholipids including cardiolipin. SGTC_2963 9082507 9 µM -1.52120365270372 0.0952466008597923 no 3027 0.0641043695571284 4508 16459611 SGTC_2827 7993847 71.43 µM -1.52640370592829 0.0945040724892491 no 3028 0.0634546776446559 4542 2985692 SGTC_2728 chlorpromazine 9.18 µM -1.53280973001438 0.0935952187496386 no 3029 0.0626613712732744 4607 2726 A thorazine and dopamine antagonist. SGTC_2385 9074692 200 µM -1.53406256497806 0.0934182300686387 no 3030 0.0625071308493659 4517 17046906 SGTC_2885 9057732 51.95 µM -1.53430319537914 0.0933842644005291 no 3031 0.0624775400030919 4522 6471414 SGTC_3197 9113331 49.47 µM -1.53534012337807 0.093238003406818 no 3032 0.0623501516220692 4499 16610459 YLR208W | YDL195W SEC13 | SEC31 SGTC_972 1319-0219 195 µM -1.53741794707643 0.0929454313074731 no 3033 0.0620954971110749 4502 23903702 SGTC_586 0957-0265 8.15 µM -1.53882552598814 0.0927476203340329 no 3034 0.0619234482065632 4423 6752309 YPR165W | YPR107C RHO1 | YTH1 SGTC_43 0570-0105 72.5 µM -1.54106477384701 0.0924335744929187 no 3035 0.0616505110611434 4482 1114046 YDL195W SEC31 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -1.54304144501002 0.0921570084567491 no 3036 0.0614103602098358 4525 616764 SGTC_512 prima-1 270 µM -1.54359956941403 0.0920790294704731 no 3037 0.0613426847063973 4514 322968 A re-activator of the apoptotic function of mutant p53. SGTC_3303 9125618 40.5795 µM -1.54568571920863 0.0917879932269586 no 3038 0.0610902439201585 4505 22695467 SGTC_80 0159-0065 512.242 µM -1.55073639958481 0.091086201787922 no 3039 0.0604824338487963 4492 1548079 SGTC_1754 st042065 16.137 µM -1.5511688878246 0.0910262930825398 no 3040 0.0604306079728073 4262 1126236 YIL048W NEO1 SGTC_1940 st075990 51.1 µM -1.55147103330011 0.0909844569328079 no 3041 0.0603944219378214 4561 1084979 SGTC_1138 3761-0006 1.03 µM -1.55650807039002 0.0902891101886936 no 3042 0.0597936625459126 4552 12061087 SGTC_1038 k292-0204 154 µM -1.56007024997079 0.0897997506133293 no 3043 0.0593716405030855 4478 4454212 SGTC_3300 9124615 50.48 µM -1.56134805808569 0.0896246911822314 no 3044 0.0592208251122544 4540 24824903 SGTC_165 k038-0023 64.381 µM -1.56176287103883 0.0895679164923146 no 3045 0.0591719307819066 4510 46368543 SGTC_128 0906-2981 13.371 µM -1.56241113736513 0.089479243030843 no 3046 0.0590955825253163 4514 6740226 SGTC_2097 5376186 200 µM -1.5637229631047 0.0893000040073563 no 3047 0.0589413213038449 4498 742755 SGTC_2096 5468907 200 µM -1.56429048272988 0.089222544782022 no 3048 0.0588746830828257 4527 759785 SGTC_1808 st050063 61.5 µM -1.57062700338889 0.0883610828353522 no 3049 0.0581346569106076 4491 4011993 SGTC_934 2950-0684 338 µM -1.57125247033826 0.0882763866860025 no 3050 0.0580620083082309 4537 1121253 SGTC_1509 1326-1131 80 µM -1.57666792225216 0.0875455942727192 no 3051 0.0574359775313815 4522 768313 SGTC_1941 st076221 61.8 µM -1.57685147779296 0.0875209035703805 no 3052 0.0574148517705261 4424 2828568 SGTC_279 1273-0055 2.93 µM -1.58657260003136 0.0862206948140902 no 3053 0.0563047386044283 4576 2847562 SGTC_3207 9114163 49.47 µM -1.59019728002317 0.0857396064328514 no 3054 0.0558951717179371 4499 849233 SGTC_2443 5493264 126.67 µM -1.59100958626615 0.0856320686290905 no 3055 0.0558037091967665 4566 5340055 SGTC_2108 5365811 200 µM -1.59985990646866 0.0844669487095704 no 3056 0.0548148327326306 4539 780283 SGTC_76 0433-0009 400.328 µM -1.60200685958999 0.084186109202826 no 3057 0.0545770463112369 4589 2841569 SGTC_1192 1488-0095 21.4 µM -1.60276782034353 0.0840867375599908 no 3058 0.0544929619415932 4579 915875 SGTC_180 1486-1293 102.781 µM -1.60505951378582 0.0837880039440222 no 3059 0.0542403540115965 4472 4140536 SGTC_285 1486-1325 46 µM -1.60744172334803 0.0834783168719128 no 3060 0.0539787518090563 4582 22310230 SGTC_2547 epiafzelechin trimethyl ether 100 µM -1.60985102598656 0.0831659834647884 no 3061 0.0537151913218895 4498 6708630 An antioxidant. SGTC_1657 st012939 43.4 µM -1.61583858247684 0.0823935844019002 no 3062 0.0530646086667792 4543 24207257 SGTC_2549 cedrol 20.94 µM -1.61716844228984 0.0822227669334473 no 3063 0.0529209631472442 4504 6708665 A sedative which affects the nervous system. SGTC_2676 harmalol 100 µM -1.61780653873504 0.0821408996527682 no 3064 0.0528521484019457 4509 5459187 A monoamine oxidase inhibitor SGTC_552 k242-0005 476 µM -1.61901442888622 0.0819860964320679 no 3065 0.0527220793136014 4597 4088318 SGTC_807 1315-0151 48 µM -1.61998092663079 0.0818623884649508 no 3066 0.0526181870816285 4552 4011080 SGTC_626 0214-0009 33 µM -1.62302379696387 0.0814738314854386 no 3067 0.0522921589476629 4600 3437874 SGTC_3026 9090633 49.47 µM -1.62400771237392 0.0813484892143979 no 3068 0.0521870812811386 4563 25236842 SGTC_634 1611-4317 11.2 µM -1.62538462967498 0.0811733262019754 no 3069 0.0520403144401494 4574 2843522 SGTC_350 k064-0020 19.8 µM -1.62635135245267 0.0810505157843055 no 3070 0.0519374666695008 4550 2790705 SGTC_898 1000-0849 28.3 µM -1.62660827799252 0.081017900105802 no 3071 0.0519101600405517 4555 6751807 SGTC_2126 5251174 33.877 µM -1.62730645999714 0.0809293187053205 no 3072 0.051836013294792 4534 790722 SGTC_488 nitrendipine 139 µM -1.62942589583041 0.0806608644515942 no 3073 0.0516114452430389 4580 4507 Dihydropyridine L-type calcium channel blocker. SGTC_2315 7733312 200 µM -1.63727539770278 0.0796724784435993 no 3074 0.0507864695409087 4472 726316 SGTC_1552 6-methylflavone 10.6 µM -1.63863145952604 0.0795026593009901 no 3075 0.0506450181772285 4511 689013 SGTC_426 0988-0037 14.6 µM -1.63967542619703 0.079372110440413 no 3076 0.0505363355039065 4562 5383008 SGTC_2522 biochanin a 4.94 µM -1.64255488979347 0.0790128722503576 no 3077 0.0502375302981209 4560 5280373 A possible chelator. SGTC_548 1436-0017 110 µM -1.6431720287736 0.0789360392786469 no 3078 0.0501736727002652 4591 9677137 SGTC_780 0109-0199 192 µM -1.64475300426762 0.0787394681709084 no 3079 0.0500103786437766 4585 610414 SGTC_3049 9092223 49.47 µM -1.64531942259554 0.0786691326874812 no 3080 0.0499519782683521 4540 8623917 SGTC_320 4092-0846 5.34 µM -1.64612045355679 0.0785697452740032 no 3081 0.0498694810929875 4546 1359356 SGTC_2953 9074162 66.49 µM -1.65278603322751 0.0777464054914525 no 3082 0.0491872087879975 4543 16451992 SGTC_183 3914-0051 30.55 µM -1.65387612336528 0.0776123817319286 no 3083 0.049076342441258 4565 1596232 SGTC_535 2293-4129 48.2 µM -1.6552090893813 0.0774487354908823 no 3084 0.048941046058104 4559 396118 YIL048W NEO1 SGTC_69 0096-0274 206.684 µM -1.65935408841615 0.0769415344648833 no 3085 0.0485222310059923 4614 6741392 SGTC_3315 9136395 68.55 µM -1.66519217622663 0.0762314470359803 no 3086 0.047937210686982 4574 16876844 SGTC_3342 9147791 14.508 µM -1.66668295979463 0.0760509247169876 no 3087 0.047788731501069 4538 1838168 SGTC_83 0170-0301 39.027 µM -1.66952643662897 0.0757075043890234 no 3088 0.0475065478101662 4600 3089716 SGTC_2413 inermin 26.06 µM -1.67332205970272 0.0752509313161149 no 3089 0.0471319560123306 4597 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1 SGTC_473 2-arachidonoylglycerol 10 µM -1.68030680511049 0.074416230706886 no 3090 0.046448818857456 4436 5282280 An endocannabinoid. SGTC_1704 st028805 70.8 µM -1.68113396740161 0.0743178519985423 no 3091 0.0463684479770177 4627 2876101 SGTC_1101 ebselen 5.29 µM -1.68565753180834 0.0737815968208156 no 3092 0.0459308905525771 4601 3194 A potent scavenger of hydrogen peroxide and hydroperoxides. SGTC_1726 st035556 14.5795 µM -1.68733252429947 0.073583783462729 no 3093 0.0457697152023902 4609 5919439 SGTC_3139 9095020 49.47 µM -1.68859647263076 0.0734347822600693 no 3094 0.0456483935609491 4474 25236292 SGTC_1261 0712-0010 12.7 µM -1.68937690123918 0.0733428963213513 no 3095 0.0455736123422738 4572 2840123 SGTC_706 4262-0057 46.9 µM -1.69350340833597 0.0728585117331363 no 3096 0.0451798433287132 4577 883298 SGTC_2871 9038510 12.99 µM -1.69405132100206 0.0727943803379544 no 3097 0.0451277656453074 4538 4945164 SGTC_1969 st069479 40.1 µM -1.69405650188895 0.0727937741383357 no 3098 0.045127273446028 4583 3895485 SGTC_1569 carminic acid 40.6 µM -1.69736619784783 0.0724073061553803 no 3099 0.0448137245109719 4637 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_3295 9122362 53.5725 µM -1.70133399786738 0.0719460666288917 no 3100 0.0444401436798677 4579 4730473 SGTC_858 0438-0351 2.77 µM -1.70224925873347 0.071839991995689 no 3101 0.0443543261510596 4577 2799119 SGTC_1556 plumbagin 1.48 µM -1.70569241506205 0.0714420196985204 no 3102 0.0440326813071362 4526 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. SGTC_2246 7293507 91.5585 µM -1.70603685570891 0.071402301298527 no 3103 0.0440006088962393 4607 887656 SGTC_669 0108-0021 26.2 µM -1.71185808433229 0.0707336002150215 no 3104 0.0434614123938515 4587 17201 SGTC_3175 9106517 49.47 µM -1.71351624337679 0.0705440061028646 no 3105 0.0433088038227685 4609 41468073 SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM -1.71451390593349 0.0704301216040853 no 3106 0.0432171926893021 4499 4330530 SGTC_3156 9099931 49.47 µM -1.71501318637709 0.0703731811771263 no 3107 0.0431714046719768 4630 18111053 SGTC_1650 st011916 45.8 µM -1.71695768357674 0.0701517583562658 no 3108 0.0429934520261727 4572 242528 SGTC_2292 7671323 168.05 µM -1.71892672014504 0.0699280876679054 no 3109 0.0428138580297107 4607 937504 SGTC_2797 7859098 81.82 µM -1.72079619086436 0.0697162352868259 no 3110 0.042643906942929 4551 972681 SGTC_1381 2324-0066 62.1 µM -1.73322819581177 0.068319959987648 no 3111 0.0415275586925666 4604 10885928 SGTC_1856 st057054 55.7 µM -1.73817436407707 0.0677704798648081 no 3112 0.0410900473987971 4574 1266018 SGTC_740 k014-0057 261 µM -1.74460757092196 0.0670609163572198 no 3113 0.0405266010347581 4593 4012779 SGTC_3102 9121669 49.47 µM -1.74998478775257 0.0664722452913249 no 3114 0.0400604693532086 4635 41905072 SGTC_2021 4019055 173 µM -1.75101713456827 0.0663596882036729 no 3115 0.0399714792910592 4389 44827708 YER133W GLC7 SGTC_1611 st001856 99.4 µM -1.75285670976942 0.0661594846282094 no 3116 0.0398133029926088 4606 647478 SGTC_1653 st012112 65 µM -1.75815806411027 0.0655851473149916 no 3117 0.0393603092035409 4587 720429 SGTC_2449 5812982 45.77 µM -1.76058499106015 0.0653235127125303 no 3118 0.0391543353983717 4542 776185 SGTC_1394 3474-0001 65.7 µM -1.76646943571954 0.0646925025624553 no 3119 0.0386585624558643 4608 5017666 YIL048W NEO1 SGTC_2941 9056145 11.23 µM -1.76713367209437 0.0646215724617203 no 3120 0.038602922269714 4572 2119517 SGTC_217 ketoconazole 989 nM -1.76718443345226 0.064616154424622 no 3121 0.0385986728973119 4416 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4 SGTC_1815 st051655 58.2 µM -1.76916146046454 0.0644054098849299 no 3122 0.0384334668420944 4590 5984156 SGTC_164 4100-3994 89.624 µM -1.77132171851517 0.0641757445488414 no 3123 0.0382536089230524 4593 4615967 SGTC_2103 5378138 10 µM -1.77268045200453 0.0640316188156006 no 3124 0.0381408360305661 4675 244142 SGTC_255 tunicamycin 200.472 nM -1.78358235774823 0.0628843083890206 no 3125 0.0372457772279994 4546 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7 SGTC_1785 bathophenanthroline 24 µM -1.78432179228516 0.0628070744908382 no 3126 0.037185695560102 4558 72812 An iron chelator. SGTC_2490 carminic acid 95.39 µM -1.78748652826006 0.0624773528613875 no 3127 0.0369294437852979 4615 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker. SGTC_816 0325-0417 81.3 µM -1.79153378478142 0.0620576532215833 no 3128 0.0366038390432013 4644 68101 SGTC_2106 5357045 167.29 µM -1.79475225901861 0.0617254710120509 no 3129 0.036346590127093 4641 668842 SGTC_430 0958-0115 16.4 µM -1.79774848185596 0.061417476845877 no 3130 0.0361084373655134 4553 6833180 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.7992623460398 0.0612623176406286 no 3131 0.0359885956851596 4599 688761 SGTC_1458 k015-0034 6.33 µM -1.80204626037972 0.0609777879165155 no 3132 0.0357690638002869 4641 3598957 SGTC_1652 st011932 78 µM -1.8076949171612 0.0604036429675088 no 3133 0.0353269980598098 4581 1551076 SGTC_913 3487-1245 167 µM -1.80820446382588 0.0603520599669182 no 3134 0.0352873420746184 4565 4016153 SGTC_2640 pentamidine 10.38 µM -1.81171164016348 0.05999795226543 no 3135 0.0350153820495762 4573 4735 Thought to act by inhibiting tRNA aminoacylation and translation. SGTC_514 4466-0038 2.65 nM -1.81699476508298 0.0594676070840845 no 3136 0.0346089574590178 4440 5722064 SGTC_2806 7952793 58.44 µM -1.81765210411156 0.0594018781181544 no 3137 0.0345586612762004 4628 2972490 SGTC_27 0485-0001 32.618 µM -1.81816170639556 0.0593509609194339 no 3138 0.0345197104758658 4643 2054479 SGTC_1450 4112-4260 37.6 µM -1.82393635542267 0.0587763715835629 no 3139 0.0340808473152031 4631 1633175 SGTC_684 1140-0066 328 µM -1.82407367314411 0.0587627615220485 no 3140 0.0340704675142873 4635 6813534 SGTC_3334 9142812 21.919 µM -1.83042774710215 0.0581356870069064 no 3141 0.0335930008822772 4622 45283678 SGTC_3067 9117431 49.47 µM -1.83190875183635 0.0579902870289471 no 3142 0.0334825082200236 4639 17150885 SGTC_394 menadione 8.33 µM -1.84208871782478 0.0569985732396945 no 3143 0.0327310869099382 4639 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress. SGTC_619 1652-1634 108 µM -1.84416259060117 0.0567981870878397 no 3144 0.0325797242236943 4627 5400454 SGTC_2516 gossypol 71.55 µM -1.84547031437655 0.056672114940756 no 3145 0.0324845764595574 4653 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. SGTC_1330 1469-0054 61.8 µM -1.846967420485 0.0565280560073246 no 3146 0.0323759311102831 4606 7102664 SGTC_2552 juarezic acid 87.02 µM -1.84807050903404 0.0564220961425303 no 3147 0.0322960716995549 4604 1549512 SGTC_103 0844-0104 51.839 µM -1.84885934677667 0.056346418452177 no 3148 0.0322390626006556 4464 5375804 SGTC_2076 5212012 200 µM -1.84930378016195 0.0563038166818054 no 3149 0.0322069801121495 4632 604802 SGTC_1033 k072-0102 21.3 µM -1.8529169139981 0.0559584164550962 no 3150 0.0319471342021158 4597 5965931 SGTC_1196 1588-0294 184 µM -1.86017419784751 0.0552697026666537 no 3151 0.0314304421526737 4681 6144269 SGTC_2469 5655019 90.81 µM -1.86219912614701 0.0550787370266272 no 3152 0.031287513787254 4685 2788239 SGTC_1428 4049-0204 61.7 µM -1.86723278264708 0.0546062845428335 no 3153 0.0309345437319669 4686 X1428 SGTC_3168 9103419 49.47 µM -1.86842998588035 0.0544943896658819 no 3154 0.0308510803453492 4693 16649256 SGTC_1304 1165-0502 251 µM -1.87580056830575 0.0538094985729174 no 3155 0.030341334968591 4646 767425 SGTC_2075 5212009 200 µM -1.87866823562191 0.0535448775613691 no 3156 0.0301449038107558 4610 780898 SGTC_1753 st043925 64 µM -1.87913422606996 0.0535019746988875 no 3157 0.0301130839162288 4666 670181 SGTC_3311 9131146 2.8755 µM -1.87986565430453 0.0534346884124918 no 3158 0.030063194912162 4619 4900406 YPR165W RHO1 SGTC_660 4031-1742 102 µM -1.88254913268861 0.0531884012966563 no 3159 0.0298807477267058 4535 6738706 SGTC_1215 3852-0577 11.2 µM -1.88328418300807 0.0531210963229575 no 3160 0.0298309328876518 4672 2884876 SGTC_1892 st058411 7.36 µM -1.89004771020036 0.0525049579314502 no 3161 0.0293757897511177 4648 3934738 SGTC_759 3486-0358 89.3 µM -1.8933080874699 0.0522099799031517 no 3162 0.0291584551368993 4634 875103 SGTC_95 0471-0001 561.058 µM -1.8975641740272 0.0518268986691638 no 3163 0.0288767587836467 4647 4015405 SGTC_2755 lomerizine 42.69 µM -1.9016588303563 0.0514604590957138 no 3164 0.0286078857087539 4599 3949 A calcium channel blocker. SGTC_2412 st077135 33.4 µM -1.90670853485656 0.0510113909915324 no 3165 0.0282791705772574 4643 13258915 SGTC_268 camptothecin 39.6153 µM -1.91204787574673 0.0505399640178965 no 3166 0.0279350267957252 4606 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic. SGTC_1655 st012546 55.1 µM -1.91906052564557 0.0499260754606559 no 3167 0.0274883372101023 4658 720985 YLR208W SEC13 SGTC_1000 4048-0884 8.67 µM -1.94442325742079 0.0477553213657275 no 3168 0.0259222157517849 4667 13040088 SGTC_2781 5567276 71.43 µM -1.9472771833973 0.0475158629883539 no 3169 0.0257507563124653 4635 2853274 SGTC_443 clozapine 122 µM -1.94755995989286 0.0474921891227756 no 3170 0.0257338193434787 4661 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1 SGTC_151 3013-0144 2.285 µM -1.94811289904112 0.0474459247188496 no 3171 0.025700727855764 4445 906558 YHR107C CDC12 SGTC_1139 k015-0024 46.9 µM -1.94822296648304 0.0474367196896178 no 3172 0.0256941449542529 4691 2766652 SGTC_1447 4239-0816 81.9 µM -1.95177455530715 0.0471404646637591 no 3173 0.0254824882390345 4702 1341554 SGTC_1876 myriocin 605 nM -1.95266656023539 0.0470662917822044 no 3174 0.025429559277589 4644 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1 SGTC_53 0973-0023 39.979 µM -1.95651638076595 0.0467472404654437 no 3175 0.0252021773484171 4600 674768 SGTC_1349 flufenamic acid 69 µM -1.95765497224874 0.0466532136363646 no 3176 0.0251352560898389 4615 3371 A non-steroidal anti-inflammatory. SGTC_1748 st037455 53.6035 µM -1.96057554149031 0.046412721800766 no 3177 0.0249642789260247 4660 580690 SGTC_2918 7977171 22.06 µM -1.96193596348818 0.0463010392420459 no 3178 0.0248849700663337 4660 2236483 SGTC_442 cape 100 µM -1.96899780351184 0.0457247669219028 no 3179 0.0244766716563984 4689 5281787 SGTC_2074 5212007 75.395 µM -1.97016667423329 0.0456299412075615 no 3180 0.0244096357830499 4638 758611 SGTC_2568 diosmetin 100 µM -1.97114605333155 0.0455506099614942 no 3181 0.0243535861766246 4671 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.  SGTC_2398 5228213 48.84 µM -1.97607343296729 0.0451531654957522 no 3182 0.0240732304362382 4637 80771 YMR134W ERG29 SGTC_2285 7945142 200 µM -1.97613647925599 0.0451480982947584 no 3183 0.0240696609014835 4668 2970608 SGTC_2229 7354935 190 µM -1.97796695428788 0.0450011774553597 no 3184 0.0239662173652813 4674 318112 SGTC_1949 st076024 69.1 µM -1.98867621842353 0.0441493067676104 no 3185 0.0233684762870127 4644 2921930 SGTC_2651 TUB2.036 5 µM -1.9919694762731 0.0438899732577632 no 3186 0.0231872035251865 4560 15992207 YFL037W TUB2 SGTC_2520 obtusaquinone 4.71 µM -1.99890512307352 0.043347831839942 no 3187 0.0228093101690581 4691 5967872 SGTC_866 0495-0101 262 µM -1.99961959426966 0.0432922920221582 no 3188 0.0227706782356665 4681 635694 SGTC_376 3970-0862 59.1 µM -2.00632049512687 0.0427741858327206 no 3189 0.022411032365099 4697 3135186 SGTC_3296 9122258 64.045 µM -2.01720796399222 0.0419430760588908 no 3190 0.0218369076647681 4657 4730474 SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -2.02161740331475 0.041610216819253 no 3191 0.0216079463657027 4660 1241132 A phosphatase inhibitor. SGTC_3061 glucosamine 200 µM -2.02243974367483 0.0415483774796088 no 3192 0.0215654713451891 4635 91431 and experimental redox chemotherapeutic SGTC_2044 5102272 200 µM -2.02972455912349 0.0410038106743596 no 3193 0.0211922725369293 4698 592666 SGTC_2188 6126565 140.678 µM -2.03082665751685 0.0409219311769751 no 3194 0.0211362909196587 4648 874518 SGTC_2164 5685496 200 µM -2.03957512410331 0.0402766660344024 no 3195 0.0206963308947006 4654 759046 SGTC_97 0535-0701 19.132 µM -2.04354215728945 0.0399868031945095 no 3196 0.0204993992891664 4616 2832013 YGL099W LSG1 SGTC_1852 st056254 31.4 µM -2.04471756075542 0.0399012452168696 no 3197 0.0204413556601362 4683 442583 SGTC_1797 st048695 56.8 µM -2.0477257803732 0.0396829535516442 no 3198 0.0202934381433231 4674 592262 YIL048W NEO1 SGTC_293 4049-0273 38.5 µM -2.0490110043518 0.0395899877213667 no 3199 0.0202305194421233 4601 1380311 SGTC_3064 1327-0027 10 µM -2.05139318916248 0.0394181423985931 no 3200 0.0201143358955424 4690 16000455 YPR107C YTH1 SGTC_2300 7976697 71.57 µM -2.05187569779165 0.0393834093506139 no 3201 0.0200908721060998 4613 2236109 SGTC_384 k007-0144 5.16 µM -2.0556516248569 0.0391124609402189 no 3202 0.0199080539453165 4677 6824886 SGTC_2193 5925765 200 µM -2.05965659878808 0.0388267371367681 no 3203 0.0197156906482053 4709 877370 SGTC_1061 3448-9325 110 µM -2.06080192125006 0.0387453406009804 no 3204 0.0196609705622168 4676 723482 SGTC_2561 acetosyringone 100 µM -2.06281724177222 0.0386024519971519 no 3205 0.01956499763231 4659 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent. SGTC_1299 1079-1439 3.74 µM -2.0692769700976 0.0381473412167731 no 3206 0.0192600517369121 4704 323161 SGTC_2223 6903751 107.57 µM -2.07331561483033 0.0378650342920289 no 3207 0.0190714582209467 4688 5598863 SGTC_60 0986-0278 202 µM -2.07752885750202 0.0375723421043023 no 3208 0.0188763873282301 4664 3110598 SGTC_1143 3454-2408 5.08 µM -2.07805855006934 0.0375356756600415 no 3209 0.018851983379695 4720 X1143 SGTC_1206 3978-0017 132 µM -2.08286099552418 0.0372045718307374 no 3210 0.0186319479078463 4676 3873677 SGTC_1810 st050138 53 µM -2.09477020305522 0.0363937817668307 no 3211 0.0180957125531032 4730 3444541 SGTC_1950 st077106 7.18 µM -2.09664173027405 0.0362676911199011 no 3212 0.0180126511373032 4635 13831864 SGTC_1469 k284-2957 126 µM -2.09789113661572 0.036183713935868 no 3213 0.017957381581319 4723 23884841 SGTC_659 k018-0002 107 µM -2.10080453464245 0.0359885121252744 no 3214 0.0178290641161377 4685 6797879 YHR007C ERG11 SGTC_2525 harmine 47.85 µM -2.10236218722879 0.0358845015641167 no 3215 0.0177607804413853 4726 5280953 A monoamine oxidase inhibitor SGTC_2840 9008771 71.43 µM -2.10335325318947 0.0358184524956903 no 3216 0.0177174507807795 4677 2992978 SGTC_1239 0337-0584 35.4 µM -2.11379448672809 0.0351286366902951 no 3217 0.0172664120346746 4715 914301 YML130C ERO1 SGTC_2475 5812728 15.03 µM -2.11743276773625 0.0348908441655723 no 3218 0.017111567831196 4679 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2 SGTC_2100 5377183 190 µM -2.13267251597667 0.0339091149143924 no 3219 0.0164758000114609 4729 2844202 SGTC_2975 9084847 53.72 µM -2.13316654174656 0.0338776744258143 no 3220 0.0164555333685897 4679 27211724 SGTC_1562 morin hydrate 59.1 µM -2.13722314725812 0.0336204122625234 no 3221 0.0162899231051834 4708 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase. SGTC_2298 7976326 193.81 µM -2.13957856536776 0.0334717754306133 no 3222 0.0161944201956354 4695 2235818 SGTC_2491 paeonol 100 µM -2.14184351682861 0.0333293580686496 no 3223 0.0161030381557084 4711 11092 Increases levels of cortical cytochrome oxidase. SGTC_2784 7567673 72.73 µM -2.14427514241664 0.033177016280054 no 3224 0.0160054236617837 4647 3471247 SGTC_895 0964-0006 13.7 µM -2.15444262919371 0.0325462225393909 no 3225 0.0156027382723664 4719 6738897 SGTC_702 1488-0190 94 µM -2.15884797162084 0.0322760023233336 no 3226 0.0154309816970397 4733 949357 SGTC_1283 0922-0125 16.4 µM -2.15887152579055 0.0322745625209775 no 3227 0.0154300677415232 4705 3360884 SGTC_2524 avocatin b 10.57 µM -2.16881555845914 0.0316714286591455 no 3228 0.0150483447780356 4736 6710748 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -2.17417788550162 0.0313500728958301 no 3229 0.0148458892554225 4706 756377 SGTC_1853 st056710 91.2 µM -2.17954745712674 0.0310309894106171 no 3230 0.0146455116074602 4733 269167 SGTC_994 3910-0338 138 µM -2.18892892528955 0.0304799521315339 no 3231 0.0143010031612251 4733 3479481 SGTC_1842 st055362 61.2 µM -2.20387788435423 0.0296186637461296 no 3232 0.0137664666354149 4721 676032 SGTC_894 0960-0238 55.9 µM -2.21729710526562 0.0288628089792591 no 3233 0.0133013977909576 4730 6741907 YDL195W SEC31 SGTC_2078 5212016 200 µM -2.21824559274623 0.0288099964935987 no 3234 0.0132690458076917 4676 1899708 SGTC_1644 st010134 20.9 µM -2.22886132730581 0.0282243672245175 no 3235 0.0129115664699465 4720 3818134 SGTC_513 4245-1575 41.7 µM -2.2422582906007 0.0274994848935007 no 3236 0.0124723418815248 4578 719745 SGTC_1982 st072467 71.9 µM -2.24285471635222 0.0274675777809828 no 3237 0.0124530923552545 4718 3163533 SGTC_57 miconazole 162.5 nM -2.24727112444904 0.0272322715573677 no 3238 0.012311352554317 4609 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20 SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -2.24969534338027 0.0271038256206762 no 3239 0.0122341456648708 4682 676296 Flavone; oxidizing agent. SGTC_966 1300-0360 30.2 µM -2.25022412726573 0.027075875556319 no 3240 0.012217360727098 4729 70588 SGTC_2696 st077691 74.316 µM -2.25375884550536 0.0268896572024218 no 3241 0.0121056715701653 4720 757133 SGTC_1399 3562-5772 25 µM -2.2610265981295 0.0265101308389937 no 3242 0.0118788050282778 4727 23847490 SGTC_1282 0886-0010 32.4 µM -2.2638795750062 0.0263623750492399 no 3243 0.0117907612540293 4739 2836211 YNL267W PIK1 SGTC_135 0933-0004 26.348 µM -2.27213514757472 0.0259386914181291 no 3244 0.0115391744052648 4689 21230617 YGL099W LSG1 SGTC_470 aa-861 153 µM -2.27684331852869 0.0256996249273561 no 3245 0.0113977918372079 4699 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor. SGTC_2621 lithochol-11-enic acid 100 µM -2.28010825611194 0.0255349266283587 no 3246 0.0113006343446578 4690 6708711 SGTC_505 gw-5074 63.9 µM -2.28826743951787 0.0251272008587412 no 3247 0.0110609757295785 4717 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases. SGTC_551 k048-0028 34.9 µM -2.2888368201838 0.0250989529494044 no 3248 0.0110444176310763 4704 6836383 SGTC_2426 5582046 32.21 µM -2.2899430745888 0.0250441459474172 no 3249 0.0110123083956833 4722 2251934 SGTC_435 c-PAF 6.7 µM -2.29095721026371 0.0249939909472548 no 3250 0.0109829442998411 4665 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase SGTC_3101 9120531 49.47 µM -2.2910534979344 0.0249892333334691 no 3251 0.010980159853697 4706 24824904 SGTC_809 3998-0021 90 µM -2.29931077117351 0.0245840531374155 no 3252 0.0107436493141184 4720 715485 SGTC_3281 9140613 49.47 µM -2.30866326454377 0.0241318039093034 no 3253 0.0104811371719624 4724 16013766 SGTC_381 3461-2219 42.7 µM -2.32063010701875 0.0235633465458744 no 3254 0.0101534079236943 4734 2883159 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM -2.32888730134035 0.0231777097126173 no 3255 0.00993251841819281 4721 442882 SGTC_2539 epi(13)torulosol 80 µM -2.33715098802571 0.0227971032134142 no 3256 0.00971566729697967 4699 6708597 SGTC_2569 tetrandrine 100 µM -2.34752167365616 0.022326917832682 no 3257 0.0094493868022969 4731 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker. SGTC_2999 9069765 71.4286 µM -2.35021844999773 0.0222060005407474 no 3258 0.00938119802857986 4701 2097066 SGTC_3010 9080089 71.4286 µM -2.36362161553365 0.0216132008127532 no 3259 0.0090486428711003 4750 17027233 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -2.36680706313032 0.0214742973670006 no 3260 0.00897114177615688 4766 688788 SGTC_2838 9002687 71.43 µM -2.37857079336608 0.0209678537849827 no 3261 0.00868994965124691 4724 6457060 SGTC_827 3253-0474 693 µM -2.38220309805218 0.0208135355893449 no 3262 0.00860470156630533 4754 5402065 SGTC_2592 piperlongumine 83.33 µM -2.39864855447223 0.0201268304166697 no 3263 0.00822785003806161 4733 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.  SGTC_3345 9148410 3.559 µM -2.40761539565454 0.0197605684286346 no 3264 0.00802854339501254 4717 4903596 SGTC_3234 9132280 49.47 µM -2.41487450581181 0.0194682194731927 no 3265 0.00787031595956304 4761 17612295 SGTC_1718 roemerine 11.9335 µM -2.41638162805751 0.0194079853547539 no 3266 0.00783781109492036 4433 235224 An aporphine alkaloid with mutagenic activity. SGTC_1731 st035964 63 µM -2.42484472080732 0.0190726798641728 no 3267 0.00765746786689075 4671 6739575 SGTC_2858 9025781 8.96 µM -2.42693885245141 0.0189904752984789 no 3268 0.00761341100409176 4603 4894980 YPL153C RAD53 SGTC_2665 lovastatin 100 µM -2.43645365019375 0.0186207592173975 no 3269 0.0074160350723654 4772 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1 SGTC_2949 9072542 2.23 µM -2.4366064837877 0.0186148709282521 no 3270 0.00741290181925832 4717 16457352 SGTC_2273 7815444 169.05 µM -2.44615229671716 0.0182502232544853 no 3271 0.00721949970075818 4710 2824616 SGTC_1388 3346-4487 254 µM -2.44828461157646 0.0181696062398328 no 3272 0.00717691109326587 4762 3345614 SGTC_3177 9107506 49.47 µM -2.45134005222461 0.0180546175082991 no 3273 0.00711627124245205 4761 8897194 SGTC_2938 9059746 27.26 µM -2.4740689783199 0.0172185517286985 no 3274 0.00667919511296693 4731 6471769 SGTC_2175 5807670 165.306 µM -2.47705678611212 0.0171111468844455 no 3275 0.00662354117712958 4746 241186 SGTC_2989 9073649 71.4286 µM -2.48610642594316 0.0167893198871335 no 3276 0.00645746681165139 4727 21367202 SGTC_1489 4065-0444 182 µM -2.48795551393554 0.0167242027661125 no 3277 0.00642399015089385 4768 2877968 SGTC_3103 9120822 49.47 µM -2.48854490225347 0.0167034924447398 no 3278 0.00641335194082954 4760 17141819 SGTC_921 1561-0023 372 µM -2.51399641437052 0.0158298539382402 no 3279 0.0059685823772562 4751 24050882 SGTC_1498 4478-3555 97.6 µM -2.52419348097646 0.0154909912050561 no 3280 0.00579820423721821 4773 3437919 SGTC_3059 1327-0034 3 µM -2.52807857433608 0.0153635321617095 no 3281 0.00573443406701128 4679 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_340 k038-0059 454 µM -2.53242292005282 0.0152220738204538 no 3282 0.00566386360043804 4769 23733424 SGTC_1456 k015-0012 13 µM -2.54029607732465 0.0149685621593814 no 3283 0.00553793309822724 4761 2989616 SGTC_319 1348-1596 45.5 µM -2.54492848911451 0.0148211034345987 no 3284 0.00546500597298876 4783 5380505 SGTC_2777 climbazole 1.536 µM -2.56364109560599 0.0142380913044933 no 3285 0.00517902954600099 4598 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2 SGTC_2586 curcumin 80 µM -2.58150752167565 0.013699987395173 no 3286 0.00491849238774411 4697 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40 SGTC_2939 9044578 71.43 µM -2.5967394799348 0.013255174902868 no 3287 0.00470566374061597 4729 2653634 SGTC_1688 st021091 57.6 µM -2.60644643126009 0.012978262711407 no 3288 0.00457435666102119 4789 3656366 SGTC_2671 danthron 100 µM -2.61760585826979 0.012666108761821 no 3289 0.00442745090282833 4763 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin. SGTC_1470 k295-0292 231 µM -2.61865034900455 0.0126372273534267 no 3290 0.00441391901366937 4795 5045612 SGTC_29 0299-0004 12.984 µM -2.62467213430489 0.0124718269519542 no 3291 0.00433662198133107 4742 16871 A napthoquinone isolated from Swertia calycina. SGTC_3075 9116269 49.47 µM -2.62699776457274 0.0124084524597544 no 3292 0.00430709499699037 4754 17015205 YNL244C SUI1 SGTC_2876 9059903 25.97 µM -2.63678502630911 0.0121447923817344 no 3293 0.00418479268339772 4773 6916095 SGTC_294 k038-0071 157 µM -2.64028814729451 0.0120516087073635 no 3294 0.00414177822007112 4786 24152826 SGTC_3142 9086498 49.47 µM -2.64627764540061 0.0118937226283376 no 3295 0.00406914945331391 4691 25236367 SGTC_2182 6325192 200 µM -2.64652306281329 0.0118872917526687 no 3296 0.0040661979797736 4784 736248 SGTC_304 1310-0298 97 µM -2.64683317304154 0.0118791699916469 no 3297 0.00406247122891646 4599 1550234 SGTC_941 3237-0776 460 µM -2.66147098351474 0.0115012436911073 no 3298 0.00389000231334853 4766 760008 SGTC_1243 0416-0003 5.65 µM -2.66725788804516 0.0113547401816585 no 3299 0.00382364832580403 4749 2141977 SGTC_1744 st037937 38.9 µM -2.6697244558337 0.0112927901712731 no 3300 0.00379567578467448 4772 1016152 SGTC_309 k408-0051 1.48 µM -2.67011852757966 0.0112829199782371 no 3301 0.00379122378166423 4713 3640463 SGTC_829 1635-0120 117 µM -2.68428613423799 0.0109330139210371 no 3302 0.00363424348442371 4767 285054 SGTC_1168 k815-0004 80.5 µM -2.7172909142739 0.0101542833782152 no 3303 0.00329093635362952 4775 642433 SGTC_286 k060-0067 22.9 µM -2.73684844856145 0.00971604110189435 no 3304 0.00310154312979197 4793 5985051 SGTC_1472 k841-0093 193 µM -2.75126157224719 0.00940373821746815 no 3305 0.00296831092937944 4789 X1472 SGTC_1919 st067113 52.3 µM -2.75701727835491 0.00928149856529738 no 3306 0.00291656345752109 4749 1268243 SGTC_1707 st032323 6.317 µM -2.76424968665817 0.00912986965388611 no 3307 0.00285269314610808 4655 3132057 YMR211W DML1 SGTC_859 0439-0102 54.6 µM -2.77582074183824 0.00889178915372257 no 3308 0.0027531279003833 4786 610143 SGTC_2327 6189656 200 µM -2.77950560698076 0.00881712188872608 no 3309 0.00272208568332882 4775 5349088 SGTC_3270 9137563 49.47 µM -2.79357897878832 0.00853698402784398 no 3310 0.00260641489972844 4782 17015724 SGTC_2216 7189485 200 µM -2.7952240125568 0.0085047540581211 no 3311 0.00259318818581339 4804 731273 SGTC_3329 9141233 27.5565 µM -2.79902618555524 0.00843066909896479 no 3312 0.00256284902872672 4764 4909101 YNL103W MET4 SGTC_1889 st059080 5.18 µM -2.80589319232432 0.00829830065794282 no 3313 0.0025088660723823 4763 176925 Isolated from Daphnopsis sellowiana. SGTC_312 4092-0653 6.84 µM -2.80939235289228 0.00823155545429717 no 3314 0.00248175575447729 4719 1148278 SGTC_2121 5257820 149.641 µM -2.84375202531341 0.00760080389307633 no 3315 0.00222928664171555 4782 791256 SGTC_1701 st028638 40.4 µM -2.85829988776535 0.00734683280164505 no 3316 0.00212958828700822 4784 3490878 SGTC_845 0330-0138 4.51 µM -2.89278287007673 0.00677450029683297 no 3317 0.00190922584587627 4775 9039800 SGTC_2399 5884133 200 µM -2.91182469817722 0.00647564312959667 no 3318 0.0017966211629551 4749 722445 SGTC_2698 st077697 67.5 µM -2.91419269834272 0.00643930549435002 no 3319 0.00178304854410312 4765 3154499 SGTC_2249 haloperidol 116.36 µM -2.91650754550006 0.0064039580078104 no 3320 0.00176987080576852 4756 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines. SGTC_570 0987-0065 62.6 µM -2.91986091319704 0.00635305695257593 no 3321 0.00175093819651621 4768 3104428 SGTC_2379 9035213 200 µM -2.93511478584542 0.00612600897501113 no 3322 0.00166712160332257 4782 646551 SGTC_875 0709-0210 25.7 µM -2.95635845823476 0.00582178986916316 no 3323 0.00155647536602928 4790 6251364 SGTC_568 1193-0097 7.48 µM -2.9685995740433 0.00565264577021175 no 3324 0.0014958007896579 4667 3646150 SGTC_3000 9075062 71.4286 µM -2.97649067466406 0.00554593554273284 no 3325 0.00145783974705091 4790 17057871 SGTC_339 3091-4833 71.4 µM -2.99268718677274 0.00533250217104867 no 3326 0.0013826651362391 4692 3240077 SGTC_1031 k035-0009 16 µM -3.11241299555475 0.00396854445639566 no 3327 0.000927823509790538 4797 5180959 SGTC_3170 9103054 49.47 µM -3.1829020409917 0.00332036148691562 no 3328 0.000729034673700595 4790 16432970 SGTC_3060 1327-0027 12.5 µM -3.20956000320075 0.00310117863453691 no 3329 0.000664691483235018 4764 16000455 YPR107C YTH1 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM -3.27358222909447 0.00262704815641669 no 3330 0.000530967438363076 4803 4000243 SGTC_2836 9010338 19.48 µM -3.34466793400391 0.00217812756386977 no 3331 0.000411905696296518 4774 2994051 SGTC_2752 diclazuril 33.15 µM -3.34689009974302 0.00216528876864606 no 3332 0.000408618015119491 4772 456389 An antifungal agent for coccidioides. YHR062C RPP1 SGTC_431 k089-0097 107 µM -3.39791825101614 0.00188872013629927 no 3333 0.000339503534343712 4655 5499420 SGTC_3278 9139605 49.47 µM -3.39964579815511 0.00187994563234419 no 3334 0.000337365982884021 4797 7958859 SGTC_562 3772-2733 112 µM -3.40462770645948 0.00185484876219003 no 3335 0.000331271563777113 4788 2876874 YIL048W NEO1 SGTC_106 0092-0003 11.579 µM -3.41651437641702 0.00179619417372458 no 3336 0.000317141573288837 4801 1072148 SGTC_1305 1181-0477 144 µM -3.44993706881768 0.00164019821010703 no 3337 0.000280358624179262 4806 6252086 SGTC_2218 6965428 192.983 µM -3.54053666892829 0.00127738032106117 no 3338 0.000199657071125512 4793 675684 SGTC_2757 clomiphene 4.22 µM -3.54778932894837 0.00125177450607195 no 3339 0.000194239407248511 4788 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. SGTC_3063 1327-0034 4 µM -3.57900017232512 0.00114685459590731 no 3340 0.000172455620354971 4761 15998580 YGL093W | YPR107C SPC105 | YTH1 SGTC_3174 9107204 49.47 µM -3.59763660789283 0.00108811085373603 no 3341 0.00016056092261515 4801 3938802 SGTC_280 3448-3607 3.04 µM -3.60175686765783 0.00107550152180865 no 3342 0.000158036952477265 4792 626179 SGTC_457 grayanotoxin iii 135 µM -3.76330805180799 0.000674921928592452 yes 3343 8.38402199387881e-05 4757 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity. SGTC_374 0880-0231 82.3 µM -3.87392859259546 0.000485645464002713 yes 3344 5.35474022805628e-05 4783 6833587 SGTC_2563 tomatine 8.54 µM -3.89647001919503 0.00045368699886896 yes 3345 4.88024418026459e-05 4783 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties. SGTC_1378 2093-0007 380 nM -3.93823706549295 0.000399565025741617 yes 3346 4.10412380043558e-05 4804 3618014 SGTC_444 curcumin 90.4 µM -3.94874066111084 0.000386930975039887 yes 3347 3.92817038917264e-05 4788 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. SGTC_1040 k898-0338 155 µM -4.00449411446665 0.000325856287063288 yes 3348 3.10751691841513e-05 4804 20969351 SGTC_352 k048-0007 5.11 µM -4.1413712147193 0.000211839597128608 yes 3349 1.72617848602253e-05 4792 6811911 SGTC_1567 st069303 68.4 µM -4.63360347492174 4.05484077385981e-05 yes 3350 1.79677505177697e-06 4808 5581319 SGTC_2456 5770359 74.46 µM -4.97165785703594 1.18407232130088e-05 yes 3351 3.31913905567298e-07 4809 3118787 SGTC_453 enantio-paf c16 10 µM -5.02742899822356 9.59228779181952e-06 yes 3352 2.48549724062584e-07 4658 13871343 A lipid and platelet activating factor SGTC_2837 9008476 45.46 µM -6.5584080051898 1.28209772398597e-08 yes 3353 2.71926203822239e-11 4810 2992805 SGTC_3266 9136860 49.47 µM -7.07650390327839 9.45028280560912e-10 yes 3354 7.3918295985869e-13 4802 4871271 YPR165W RHO1 SGTC_1787 fluconazole 80 µM -7.41564454251176 1.54913293218622e-10 yes 3355 6.05173600846108e-14 4794 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C SGTC_2896 9052656 71.43 µM -10.0844462719229 6.11914649931676e-18 yes 3356 3.23645523578182e-24 4800 6469436