SGTCid condition conc unit PHO87|YCR037C.score PHO87|YCR037C.strain.pval PHO87|YCR037C.strain.significant PHO87|YCR037C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_1365 1672-3266 55.4 µM 7.32706091223291 7.59509308726651e-14 yes 1 1.17627457884664e-13 1 6415873
SGTC_2247 cerulenin 830 nM 7.19199607982564 2.10043173254765e-13 yes 2 3.19254320437791e-13 3 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_2104 5389443 200 µM 6.90102429461186 1.76600956424166e-12 yes 3 2.58144507078485e-12 3 2244536
SGTC_2243 6634756 200 µM 6.2642510061479 1.38668885370352e-10 yes 4 1.87310813961436e-10 2 885676
SGTC_2256 7954252 200 µM 6.21423267825697 1.92027437947757e-10 yes 5 2.57880278701817e-10 1 2972920
SGTC_166 k072-0058 166.424 µM 5.52007967805428 1.36003679180465e-08 yes 6 1.69422990899149e-08 8 5846229
SGTC_1729 st035615 45.989 µM 5.35856809234733 3.42107665305974e-08 yes 7 4.1942060740041e-08 11 17385451
SGTC_208 k072-0098 12.366 µM 5.13048728733464 1.20431810655825e-07 yes 8 1.44496538925413e-07 24 5948901
SGTC_2837 9008476 45.46 µM 5.07398205874831 1.63189024998485e-07 yes 9 1.94787901964105e-07 12 2992805
SGTC_1950 st077106 7.18 µM 4.97427052673592 2.76813479138574e-07 yes 10 3.27468972017955e-07 12 13831864
SGTC_773 4358-1457 44.6 µM 4.83368327022873 5.73469484520196e-07 yes 11 6.70148864007757e-07 24 1186886
SGTC_464 bw-b 70c 158 µM 4.64665079257744 1.46623158733554e-06 yes 12 1.68683774061251e-06 9 5353454
SGTC_1896 st058441 89 µM 4.60399830954889 1.80750592310571e-06 yes 13 2.07227913592174e-06 5 688759
SGTC_1246 0422-0085 105 µM 4.5856919381937 1.97626644791851e-06 yes 14 2.26242683816649e-06 14 264295
SGTC_3000 9075062 71.4286 µM 4.51420332476962 2.79163829157331e-06 yes 15 3.17776106417868e-06 9 17057871
SGTC_3224 9130643 49.47 µM 4.36230564283866 5.71958534795825e-06 yes 16 6.4349451115444e-06 18 17644395
SGTC_1041 0206-0046 107 µM 4.20069721738378 1.19672249934802e-05 yes 17 1.33047130002134e-05 26 50494
SGTC_1540 guanosine 70.6 µM 4.19215523781059 1.2434593584832e-05 yes 18 1.38158403425757e-05 4 6802 Guanosine is a purine nucleoside
SGTC_997 3996-0078 137 µM 4.15196302198444 1.48765538094974e-05 yes 19 1.64817766602222e-05 17 735687
SGTC_1225 1216-0074 20.6 µM 4.13750534620062 1.58615542194647e-05 yes 20 1.75551135545114e-05 20 4241466
SGTC_2623 humulene 100 µM 4.08416770041624 2.00585325282587e-05 yes 21 2.21175386837269e-05 16 6187145 An anti-inflammatory.
SGTC_801 0866-0028 10.1 µM 4.07355516238086 2.10107134247359e-05 yes 22 2.3150439295868e-05 26 6849771
SGTC_92 0063-0024 660.874 µM 3.96388615728708 3.37122824527059e-05 yes 23 3.68697139853265e-05 13 3594437
SGTC_3016 9080866 49.47 µM 3.90693859712687 4.28953760591742e-05 yes 24 4.67364474634158e-05 26 17066299
SGTC_2239 6685329 187.64 µM 3.84701370253096 5.50836554830973e-05 yes 25 5.9783142388841e-05 33 805680
SGTC_80 0159-0065 512.242 µM 3.81428406525779 6.30527716249419e-05 yes 26 6.82891486650294e-05 4 1548079
SGTC_2069 5228469 200 µM 3.73108785689934 8.84778053808275e-05 yes 27 9.53273576023066e-05 18 2835210
SGTC_1060 3448-7350 82 µM 3.72609737308069 9.02749300890378e-05 yes 28 9.72336525744639e-05 40 570178
SGTC_838 0109-0203 71.4 µM 3.71890868715035 9.29240585235498e-05 yes 29 0.000100042680294676 19 759422
SGTC_2184 6075246 200 µM 3.64266647584354 0.00012589551850666 yes 30 0.000134914179353786 37 2267320
SGTC_1621 st003705 32.4 µM 3.62635782184598 0.000134246605691702 yes 31 0.000143723485303398 32 24207032
SGTC_1626 st003712 1.76 µM 3.61400055162201 0.000140917136941123 yes 32 0.000150754209161193 30 24207035
SGTC_2340 7987427 183.45 µM 3.60551713805928 0.000145674979731226 yes 33 0.000155765964762813 53 2239331
SGTC_1746 st038117 42 µM 3.59340066619412 0.000152731860602352 yes 34 0.000163195055871827 42 2898218
SGTC_1444 4112-3581 28 µM 3.53739709277568 0.000189709378412801 yes 35 0.000202045811040157 22 2877249
SGTC_868 0527-0199 213 µM 3.43180165048544 0.000283172979981812 yes 36 0.000299792955315965 44 2849450
SGTC_760 0568-0725 82.9 µM 3.36086312052157 0.000368383915976054 yes 37 0.000388496606727078 21 3916171
SGTC_1039 k821-0043 94 µM 3.34550046729348 0.000389731890935846 yes 38 0.000410671103970881 48 15992768
SGTC_2218 6965428 192.983 µM 3.25049622985145 0.000549384624331311 yes 39 0.000576018979696388 20 675684
SGTC_2887 9044784 58.44 µM 3.2484103075494 0.000553488016390677 yes 40 0.000580258950208672 71 6465546
SGTC_2128 5255449 168.493 µM 3.24617648083898 0.000557913776475128 yes 41 0.000584831530518431 65 736008
SGTC_1852 st056254 31.4 µM 3.24424886233908 0.000561759139219421 yes 42 0.00058880405142657 28 442583
SGTC_3009 9080819 71.4286 µM 3.22526644094862 0.00060095729666368 yes 43 0.000629277398213716 38 17027216
SGTC_1047 2043-3044 82 µM 3.20409068087628 0.000647656996657653 yes 44 0.000677448974496983 72 669592
SGTC_2121 5257820 149.641 µM 3.17563514616211 0.00071569250376912 yes 45 0.000747544309856761 32 791256
SGTC_2995 9067767 71.4286 µM 3.13000338879821 0.00083867183010708 yes 46 0.000874021432773205 49 11673567
SGTC_1198 1612-1005 86.7 µM 3.11960047458537 0.000869302345202564 yes 47 0.000905482432947652 40 6998509
SGTC_1531 st059297 52.4 µM 3.08159186603259 0.000990168696167905 yes 48 0.00102948465855947 53 7566702
SGTC_1859 st055998 20 µM 3.05413361201892 0.00108688025429147 no 49 0.00112855765324997 57 676301
SGTC_2389 9091542 195.52 µM 3.04983485399376 0.00110278204339652 no 50 0.00114483615649593 83 3626624 YOL127W RPL25
SGTC_1586 deoxycorticosterone acetate 53.7 µM 3.03733190888969 0.00115025215184028 no 51 0.00119341241450787 42 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_1156 4092-0367 4.88 µM 3.02636313602473 0.00119343098578639 no 52 0.00123757423024464 68 1357585
SGTC_2438 5259590 200 µM 3.00761848068735 0.00127066806977247 no 53 0.00131651732334673 50 1201127
SGTC_12 0849-0099 9.267 µM 3.00147108664134 0.001296977080238 no 54 0.00134339276625576 52 6071388
SGTC_1755 st041960 45.185 µM 3.0004134819774 0.0013015532068301 no 55 0.00134806667831962 60 2257073
SGTC_3008 9078912 71.4286 µM 2.96564093913389 0.0014604839869501 no 56 0.00151026455046271 56 16648731
SGTC_2740 felodipine 17.08 µM 2.95354665263107 0.00151978665373489 no 57 0.00157072560720198 52 3333 L-type calcium channel blocker
SGTC_2489 cantharidin 73.42 µM 2.92719174247228 0.0016566919832407 no 58 0.00171018968979448 107 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1197 1601-0112 267 µM 2.91486235207312 0.00172451810842927 no 59 0.0017792272580934 76 7350313
SGTC_471 1-acyl-paf 4 µM 2.90504661456288 0.00178031273138276 no 60 0.00183599204268308 70 16759367
SGTC_1257 0669-0121 16 µM 2.90037300835476 0.00180745130159734 no 61 0.00186359415657818 87 4307855
SGTC_1238 0333-0287 48.8 µM 2.89073852963867 0.00186458728913875 no 62 0.00192168870895433 79 7226
SGTC_1069 diphenylcyclopropenone 8.49 µM 2.88480083030889 0.00190061279572128 no 63 0.00195830679984667 84 65057 A dermal irritant. YDR527W RBA50
SGTC_1900 st060200 72.8 µM 2.82511640208807 0.00229947537803622 no 64 0.00236317212687433 69 688945
SGTC_2643 anethole 100 µM 2.81735640968277 0.00235655908873658 no 65 0.00242103801929903 61 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_1495 4469-0029 237 µM 2.80524058291389 0.00244825328122196 no 66 0.00251395179746722 201 793680
SGTC_1579 chlormadinone acetate 49.4 µM 2.79874949615226 0.00249869533925214 no 67 0.00256504597975734 59 45114258 A steroidal progestin.
SGTC_1151 3909-8316 15.3 µM 2.76362804931303 0.00278828090284866 no 68 0.00285813293044987 73 800431
SGTC_58 0957-0393 9 µM 2.75479375779244 0.00286573468646185 no 69 0.00293645714105135 531 6997992
SGTC_2447 5741742 33.78 µM 2.73707071486014 0.00302699703663804 no 70 0.00309944831779408 98 1776504
SGTC_1447 4239-0816 81.9 µM 2.73291430439735 0.00306598030564093 no 71 0.00313883316795812 96 1341554
SGTC_2109 5483026 200 µM 2.72645586359852 0.00312745210454497 no 72 0.00320092568946611 99 759335
SGTC_632 0781-2353 4.65 µM 2.72038414673819 0.00318625256345681 no 73 0.00326030582483823 117 6811515 YHR007C ERG11
SGTC_66 0109-0187 42.4 µM 2.7095638217313 0.00329351096583107 no 74 0.00336858710296104 96 759417
SGTC_1906 st060206 94.7 µM 2.6677423584002 0.00373925927567385 no 75 0.00381813956710849 99 5133468
SGTC_664 1222-0054 14.9 µM 2.66044841656783 0.00382231927061791 no 76 0.00390183398327835 110 6813991
SGTC_1136 pergolide 1.05886 µM 2.65913033166275 0.00383750421650215 no 77 0.00391713252148555 149 47811 A dopamine receptor agonist.
SGTC_2736 butenafine 14.65 µM 2.65669726690063 0.00386567632572021 no 78 0.00394551344014292 110 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1537 2',6'-dihydroxyflavanone 78 µM 2.64657930550503 0.00398482896565548 no 79 0.00406552185592353 100 5106787 A p450 inhibitor.
SGTC_1336 1486-0901 104 µM 2.63373996076677 0.0041407591157785 no 80 0.00422250690533614 84 5006114
SGTC_572 0960-0087 17.7 µM 2.62482499070656 0.00425221750237421 no 81 0.00433467572461717 140 6796365
SGTC_2792 7535235 81.82 µM 2.62083547025584 0.00430295919767958 no 82 0.0043857291413583 110 1281891
SGTC_1923 st058458 19.1 µM 2.60914711113799 0.004454750682573 no 83 0.00453841058034856 139 3534982
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM 2.60729223173802 0.00447927400044685 no 84 0.00456307180926414 72 616764
SGTC_851 0394-0702 453 µM 2.60354040316125 0.00452924571510048 no 85 0.00461331959035611 86 762646
SGTC_177 1327-0068 8.361 µM 2.59985110366935 0.00457886936588902 no 86 0.00466321086951688 142 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1779 st039427 55 µM 2.58731063696243 0.00475119573777713 no 87 0.00483641730580428 139 1124498
SGTC_2694 st077685 81.9 µM 2.58530581138763 0.00477927517994379 no 88 0.00486463303640578 120 2838096
SGTC_422 cantharidin 155 µM 2.56779238854687 0.00503092828049249 no 89 0.00511742169017606 171 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2790 5423970 71.43 µM 2.55519306155902 0.00521920035698901 no 90 0.00530644577455405 166 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1508 1080-0625 72.9 µM 2.52734865910936 0.0056576741627971 no 91 0.00574636723706461 84 767111
SGTC_1587 estradiol valerate 56.1 µM 2.52730238779406 0.00565842923912661 no 92 0.00574712445554453 79 13791 A steroid.
SGTC_1421 4029-0249 71.4 µM 2.52370106307291 0.00571747247058282 no 93 0.00580633158267773 99 2894095
SGTC_2671 danthron 100 µM 2.5004722106275 0.00611161729518636 no 94 0.00620139316002498 146 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1487 3970-0795 2.82 µM 2.49046010971447 0.00628879939145764 no 95 0.00637889080718407 102 3765103
SGTC_305 1682-2595 20.8 µM 2.48524698289118 0.00638284344361273 no 96 0.00647307899904183 113 226033
SGTC_829 1635-0120 117 µM 2.48376993631914 0.00640971444374983 no 97 0.00649998826287226 144 285054
SGTC_3182 9108849 49.47 µM 2.46418014630695 0.00677568422095928 no 98 0.00686635354729847 112 17133045
SGTC_3174 9107204 49.47 µM 2.45999562177968 0.00685620975855617 no 99 0.00694693553512485 139 3938802
SGTC_2943 9068529 45.32 µM 2.44720604836753 0.0071075916259915 no 100 0.00719842540080685 133 3270634
SGTC_900 1112-0045 141 µM 2.43477138752442 0.0073597589529442 no 101 0.00745060046161086 104 56211 YIL048W NEO1
SGTC_1588 farnesol 29.9 µM 2.39702474657291 0.00817418025566626 no 102 0.00826440368323772 118 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3075 9116269 49.47 µM 2.39171797956604 0.00829480814123765 no 103 0.00838486130293031 113 17015205 YNL244C SUI1
SGTC_2654 protoveratrine a 100 µM 2.37664988006314 0.00864588215633441 no 104 0.00873533107060769 92 5702278 A heart drug and vasodilator.
SGTC_2793 7325131 81.82 µM 2.37639772522869 0.00865186636720611 no 105 0.00874130360947602 119 4176441
SGTC_157 1348-1695 65.819 µM 2.36661268671021 0.00888691082751432 no 106 0.00897585418989145 213 5380510
SGTC_1191 1487-1166 10.6 µM 2.35876725473298 0.00907938738920896 no 107 0.00916787581517626 158 3955771
SGTC_514 4466-0038 2.65 nM 2.35029269334333 0.00929139072766097 no 108 0.00937932686776706 314 5722064
SGTC_1442 4112-3290 3 µM 2.3486432728926 0.00933315323097317 no 109 0.00942097436767266 137 704353
SGTC_2007 4011539 71.82 µM 2.34168037065014 0.00951126560128854 no 110 0.00959857372764993 186 45595301
SGTC_1584 6-fluoro-dl-tryptophan 90 µM 2.32453462298701 0.00996257990410011 no 111 0.010048429069644 146 94937 An inhibitor of serotonin biosynthesis.
SGTC_2663 amphotericin b 100 µM 2.31941325497115 0.0101009623045848 no 112 0.0101863198123967 109 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1295 1013-0063 9.78 µM 2.31379852793924 0.0102546000934235 no 113 0.0103393880816808 133 6826038
SGTC_293 4049-0273 38.5 µM 2.30642486026436 0.0104594615196043 no 114 0.0105434521045467 101 1380311
SGTC_3180 9109287 49.47 µM 2.30001282344491 0.0106404962740074 no 115 0.0107237467768246 134 18891271
SGTC_2365 9042475 200 µM 2.29213977701055 0.0108665084167761 no 116 0.010948789366741 170 6464479
SGTC_974 1326-0144 138 µM 2.27659539435025 0.0113250359277023 no 117 0.0114051990848413 197 5411856
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM 2.27009346455162 0.0115217618725516 no 118 0.0116009563923834 149 279621
SGTC_2366 9070441 60.58 µM 2.26660878520672 0.0116284127494233 no 119 0.0117070674713506 180 6837235
SGTC_272 doxorubicin 8.13 µM 2.26106797389911 0.0117997578631783 no 120 0.0118775240942939 197 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1696 st025591 34.7925 µM 2.25218806217927 0.0120789315203562 no 121 0.0121551950502223 174 2787147
SGTC_2297 7971671 152.32 µM 2.24951554759993 0.0121640654493382 no 122 0.0122398573882462 155 909016
SGTC_1677 st019204 53.9 µM 2.22305577371435 0.0130353989716773 no 123 0.0131060196745321 180 3945625
SGTC_2763 lisinopril 49.32 µM 2.20945685293424 0.01350384784709 no 124 0.0135714401751654 114 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_701 4424-0219 185 µM 2.19547756121372 0.0140004768693258 no 125 0.0140646793872675 165 2911779
SGTC_890 0929-0006 47.2 µM 2.19454205026724 0.0140342668203718 no 126 0.0140982321910178 156 1378169
SGTC_1738 st035555 74 µM 2.19341776549706 0.0140749681159517 no 127 0.0141386467504555 206 5331140
SGTC_2745 rifampicin 24.3 µM 2.1923084741431 0.014115226281572 no 128 0.0141786201412057 75 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_627 1391-0720 175 µM 2.1898631802208 0.0142043209495364 no 129 0.014267080494921 149 997839
SGTC_1987 st072290 61.9 µM 2.1844659697715 0.0144026853620315 no 130 0.0144640126218017 156 54697379
SGTC_517 1365-0151 113 µM 2.18205067690477 0.0144922246208643 no 131 0.0145528964092724 186 768657
SGTC_2129 girgensonine 121.053 µM 2.18149097380585 0.0145130420737774 no 132 0.0145735606769871 200 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_525 k781-2675 26.7 µM 2.17759038829627 0.0146588354096599 no 133 0.0147182728861327 213 3651118 YDL195W SEC31
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM 2.16750488742133 0.0150416582219405 no 134 0.0150981887159844 152 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2779 methotrexate 400 µM 2.15349369526651 0.0155877316679853 no 135 0.0156399495305183 194 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_2016 5121758 140 µM 2.15001472391054 0.0157259287033172 no 136 0.0157770250690335 252 2795203
SGTC_1298 1079-1278 263 µM 2.14395780964292 0.0159690390413343 no 137 0.016018133733569 176 2840950
SGTC_2463 5473429 200 µM 2.13580239294565 0.0163014626916402 no 138 0.0163477620059952 168 5399405
SGTC_884 0851-0618 334 µM 2.12953561327849 0.0165609141128452 no 139 0.0166049858326196 195 9642473
SGTC_2864 9034755 47.6 µM 2.12848409419093 0.0166047925959212 no 140 0.0166484836733539 179 4930451
SGTC_2170 morpholine 200 µM 2.12442338440143 0.0167751757483274 no 141 0.016817378162624 149 121171 Reacts with secondary amines.
SGTC_1683 st010134 710 nM 2.12363678103215 0.0168083531387094 no 142 0.0168502637275194 210 3818134
SGTC_790 1575-0012 79.1 µM 2.11685764048494 0.0170966172146417 no 143 0.0171359658255446 213 378741 YLR208W SEC13
SGTC_1068 loratadine 26.9 µM 2.11613085603285 0.0171277710085063 no 144 0.0171668399221855 186 3957 A H1 histamine antagonist.
SGTC_2789 5281112 71.43 µM 2.10426851438175 0.0176431517153213 no 145 0.0176775154685971 234 765948
SGTC_1996 st072960 66.8 µM 2.09494989292749 0.018057244520903 no 146 0.0180877234812132 182 1719405
SGTC_1090 efavirenz 20.7 µM 2.08482904879957 0.0185163437478004 no 147 0.0185424104450807 185 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_61 0978-8327 98.565 µM 2.08263669050294 0.0186170921393292 no 148 0.0186421760906466 215 6150059 YHR072W ERG7
SGTC_1032 k061-1018 98.7 µM 2.08128245653895 0.01867955793918 no 149 0.018704029988748 236 4005393
SGTC_2652 actinonin 100 µM 2.06697990494066 0.0193502438594994 no 150 0.0193680237589808 132 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_2560 caryophyllene 100 µM 2.0613742769077 0.0196186328916095 no 151 0.0196336734746958 220 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_2883 9059145 45.46 µM 2.058048280244 0.0197793658431271 no 152 0.0197927495171652 162 16476510
SGTC_2894 9048625 32.47 µM 2.05390042211832 0.0199813812083296 no 153 0.019992665237513 180 4092861
SGTC_2026 5148700 152 µM 2.05090347635863 0.0201284299993889 no 154 0.0201381737743496 204 79838
SGTC_1135 dihydrocapsaicin 536.708 nM 2.04954496512618 0.0201953887081697 no 155 0.0202044278334598 235 107982 A Capsaicinoid.
SGTC_304 1310-0298 97 µM 2.03830581951186 0.0207566260369816 no 156 0.0207596791280133 272 1550234
SGTC_1235 benzylparaben 21.5 µM 2.02098062863472 0.0216476191596411 no 157 0.021640885206587 191 7180
SGTC_1832 st054113 55 µM 2.0196298448987 0.0217184247181639 no 158 0.0217108985136162 162 1251267
SGTC_675 1309-0189 238 µM 2.01075484113658 0.0221885178573619 no 159 0.0221756791112547 194 4246530
SGTC_924 2046-0044 21.3 µM 2.01033296272379 0.0222110761474373 no 160 0.0221979801944201 192 3623589
SGTC_2889 9059656 51.95 µM 2.00251682728667 0.0226325264995924 no 161 0.0226145875816628 195 3949838
SGTC_2683 piperine 63.03 µM 1.99920624052479 0.0228130568484346 no 162 0.0227930218201574 181 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_899 1083-0020 478 µM 1.98882739339915 0.0233869111774641 no 163 0.0233601290336872 232 767123
SGTC_3173 9105693 49.47 µM 1.98335310299721 0.0236944505535848 no 164 0.0236640008166518 243 17096658
SGTC_1979 st071809 45.3 µM 1.98008788175833 0.0238795009178142 no 165 0.0238468272977655 197 4976333
SGTC_994 3910-0338 138 µM 1.97870748423965 0.0239580969174001 no 166 0.0239244749177389 263 3479481
SGTC_331 k048-0133 24.5 µM 1.97563375611663 0.0241338876808382 no 167 0.0240981362884242 181 6813582
SGTC_3124 9127567 49.47 µM 1.97213197164944 0.0243354786817174 no 168 0.0242972715164441 193 17592030
SGTC_1633 st005664 67.9 µM 1.96311552619288 0.0248610541390763 no 169 0.0248163759308805 262 2063822
SGTC_2622 2-methoxyxanthone 59.94 µM 1.96135959546402 0.0249645083669197 no 170 0.0249185449033598 208 71034 A hepatoprotective.
SGTC_2960 9079389 5.97 µM 1.96110225033492 0.0249797006624879 no 171 0.0249335481437973 239 16457355
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 1.96090329340866 0.02499145133957 no 172 0.0249451525385713 260 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_1250 0485-0349 40.2 µM 1.95949471769033 0.0250747764291165 no 173 0.0250274389492819 247 6842794 YDL195W SEC31
SGTC_717 1532-0246 73.2 µM 1.95159288247652 0.0255465428119243 no 174 0.0254932794741025 249 9561992
SGTC_1376 2910-0861 41.3 µM 1.94533015770669 0.025925708087672 no 175 0.0258676273540731 257 1112859
SGTC_2667 digitoxin 100 µM 1.93808356711253 0.0263703041757259 no 176 0.026306513983651 128 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1666 st014829 29 µM 1.93756641696279 0.0264022747495878 no 177 0.0263380715034171 267 3858230
SGTC_1127 asiatic acid 681.4 nM 1.93588989572013 0.0265061412414917 no 178 0.0264405937740911 252 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_2122 5258151 111.688 µM 1.92910767617683 0.0269298145561538 no 179 0.0268587481240382 254 2173356
SGTC_2556 citropten 84.59 µM 1.92812433870167 0.0269917086233937 no 180 0.0269198311546965 277 2775 A potential DNA crosslinker.
SGTC_3191 9110352 49.47 µM 1.91994252924232 0.0275113129644154 no 181 0.0274325795595357 190 17122424
SGTC_3052 9092717 49.47 µM 1.91516077355757 0.0278188318321043 no 182 0.0277360016595478 246 25237534
SGTC_3278 9139605 49.47 µM 1.91097286253853 0.0280905074697584 no 183 0.0280040342047563 237 7958859
SGTC_898 1000-0849 28.3 µM 1.90482556648815 0.0284932896365888 no 184 0.0284013746726361 195 6751807
SGTC_574 1315-0397 40 µM 1.89859952648627 0.0289061171005477 no 185 0.0288085753643963 321 6794277
SGTC_144 4161-2749 112.381 µM 1.89391124912656 0.0292202517895124 no 186 0.0291183955520816 197 797501 YMR168C CEP3
SGTC_1273 0849-0096 14.1 µM 1.88447142837266 0.0298613660612151 no 187 0.0297506180078677 256 5286025
SGTC_1872 amphotericin b 148 nM 1.88387808591718 0.0299020502056384 no 188 0.029790734036677 248 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_1708 st033234 31.827 µM 1.88161061076309 0.0300579496046883 no 189 0.0299444522428011 260 674664
SGTC_3204 9114183 49.47 µM 1.88088311050588 0.0301081111847304 no 190 0.0299939105976881 255 17027248
SGTC_803 4488-1585 147 µM 1.87409201636901 0.0305797171926889 no 191 0.0304588717647429 224 747204
SGTC_1667 st014849 34.6 µM 1.87144548526942 0.0307651541778292 no 192 0.0306416796591152 222 5348460
SGTC_3126 9127922 49.47 µM 1.87113666520053 0.030786853093218 no 193 0.0306630703353809 291 45595682
SGTC_2141 5621638 7.665 µM 1.8708503497174 0.0308069820650052 no 194 0.0306829132582613 229 2856238
SGTC_3238 9133470 49.47 µM 1.8706255893268 0.0308227911323939 no 195 0.0306984975910446 216 3534688
SGTC_2118 5526350 200 µM 1.86839813516922 0.0309798278907282 no 196 0.0308532984113057 260 743594
SGTC_56 0957-0365 83.25 µM 1.8655513935924 0.0311814879760671 no 197 0.0310520777251067 291 6752360
SGTC_40 0327-0103 19.753 µM 1.85565665456044 0.0318908839149492 no 198 0.0317512564012428 277 409036
SGTC_5 0352-0601 109.883 µM 1.83801235053825 0.0331889414686669 no 199 0.033030292710941 197 762456
SGTC_98 0074-0023 107.663 µM 1.82790319165837 0.0339520612824393 no 200 0.0337820409889013 299 3563821
SGTC_1011 4112-3381 17.4 µM 1.82699542125339 0.0340212875017611 no 201 0.0338502289176904 296 2877139
SGTC_3056 9094900 49.47 µM 1.82307310290324 0.0343217375065167 no 202 0.0341461598545869 290 25236784
SGTC_2985 9022375 71.43 µM 1.82271247584862 0.0343494707022989 no 203 0.0341734748751104 285 4939335
SGTC_2931 9014674 55.67 µM 1.8133376448118 0.0350769066363752 no 204 0.0348898802525283 294 2996810
SGTC_826 1683-5028 118 µM 1.80979923665855 0.0353547334648914 no 205 0.0351634631789005 253 722377
SGTC_981 1488-1094 54.9 µM 1.80870966474059 0.0354406464167389 no 206 0.0352480603567939 216 3449522
SGTC_2636 apigenin dimethyl ether 100 µM 1.80191656069699 0.0359801523649354 no 207 0.0357792671351225 339 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_1837 st055472 66.5 µM 1.79766960036044 0.036320848982761 no 208 0.0361146907900443 292 676091
SGTC_2905 7799065 20.05 µM 1.79672161978699 0.0363972565916828 no 209 0.0361899124732398 239 1296806
SGTC_1436 4092-1007 8.32 µM 1.79633725418105 0.0364282740705171 no 210 0.0362204481787074 271 2881121
SGTC_3284 9108171 64.8615 µM 1.79334521231708 0.0366704657096445 no 211 0.0364588711055253 243 8687505
SGTC_1174 0739-0097 51.1 µM 1.7917768835876 0.0367979396832935 no 212 0.036584356574417 303 728447
SGTC_1720 st037298 9.481 µM 1.78277633685158 0.0375365297617145 no 213 0.0373113595974869 293 597396
SGTC_3306 9127676 59.7925 µM 1.77993466496702 0.0377722177446374 no 214 0.0375433268798414 296 41905287
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 1.77858120441498 0.0378848975225932 no 215 0.0376542239190882 271 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1773 st048542 73.5835 µM 1.77227002074162 0.0384139499779554 no 216 0.0381748726067902 332 3237138
SGTC_88 0180-0332 8.668 µM 1.77191683377241 0.0384437339113739 no 217 0.0382041818078189 301 3101745
SGTC_1721 st082152 9.2685 µM 1.76770203410963 0.0388006187911154 no 218 0.0385553648827626 275 5296051
SGTC_2180 6301957 200 µM 1.76709462750754 0.0388522722421899 no 219 0.0386061910584615 232 845462
SGTC_2585 alliin 100 µM 1.75967054427544 0.0394881482423056 no 220 0.0392318414435937 328 87310 A garlic compound which reacts with lipids.
SGTC_1999 st074831 12.5 µM 1.75755039594522 0.0396712858521288 no 221 0.0394120199025274 320 17112523
SGTC_472 calcifediol 10 µM 1.75442856499381 0.0399422050335062 no 222 0.0396785501502792 224 5283731 A vitamin D metabolite.
SGTC_830 4076-0286 57.8 µM 1.75435250480731 0.0399488244165211 no 223 0.0396850621289109 496 6866659
SGTC_1949 st076024 69.1 µM 1.75060954138607 0.0402756708954772 no 224 0.0400065953091899 330 2921930
SGTC_1747 st037496 66.6 µM 1.7461331129916 0.0406694141614443 no 225 0.0403939120497311 333 723305
SGTC_2064 5220758 200 µM 1.74384795639928 0.0408716159978637 no 226 0.0405928028158798 354 788518
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 1.74321006035651 0.0409282055386117 no 227 0.0406484643950578 364 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2964 9083345 53.42 µM 1.73969937918066 0.041240786288886 no 228 0.0409559092092085 306 17741579
SGTC_2575 plumbagin 510 nM 1.73623700022381 0.0415509591371851 no 229 0.0412609687439471 324 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2326 6164455 177.58 µM 1.72693971852915 0.0423932039044749 no 230 0.0420892451203524 304 2888790
SGTC_410 α-linolenic acid 100 µM 1.72394190514077 0.0426677029291426 no 231 0.042359165666166 329 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_2903 5923464 63.88 µM 1.72362241833941 0.0426970417295277 no 232 0.0423880143672042 254 2876576
SGTC_2753 fluvastatin 17.09 µM 1.72349851240336 0.0427084245267113 no 233 0.0423992069781842 350 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_3216 9129716 49.47 µM 1.71596784699121 0.0434048581878002 no 234 0.0430839637328894 298 8056934
SGTC_1939 st074455 53.6 µM 1.71467082796584 0.0435257265658896 no 235 0.04320279745718 333 1644229
SGTC_980 1473-0395 201 µM 1.71315817904009 0.0436670323691839 no 236 0.0433417215705698 256 768876
SGTC_2921 7974240 10.71 µM 1.71131682006948 0.0438395443183766 no 237 0.0435113214921953 333 2979074 YDR527W RBA50
SGTC_1066 ketoconazole 628 nM 1.71019922759495 0.0439445163566592 no 238 0.0436145192507452 350 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_786 4544-0069 423 µM 1.70757331128892 0.04419195843271 no 239 0.0438577720091144 341 748821 YLR208W SEC13
SGTC_1486 3970-0793 4.53 µM 1.70154521301773 0.044764240114623 no 240 0.0444203276660652 282 2844330
SGTC_1697 st025554 27.742 µM 1.69788845321454 0.045114295332242 no 241 0.044764408494969 291 1269519
SGTC_2403 6032726 181.2 µM 1.69280353113676 0.0456047237368706 no 242 0.0452464351694643 347 2881040
SGTC_469 w7 172 µM 1.68867214655002 0.0460063339159984 no 243 0.0456411381166491 223 45115570 A P450 inhibitor.
SGTC_1723 st034307 2.5525 µM 1.68607659000938 0.0462600968091732 no 244 0.0458905241660639 331 867466
SGTC_3147 9097027 49.47 µM 1.68402043734656 0.0464619199848771 no 245 0.0460888595429107 325 25236841
SGTC_1379 2144-0755 36.5 µM 1.67591816419762 0.0472640935588459 no 246 0.0468771116428415 365 5392327
SGTC_2884 9058502 51.95 µM 1.67459231106116 0.0473964116117316 no 247 0.0470071244485826 349 6471554
SGTC_1107 amlodipine 47 µM 1.66788046235527 0.048070804394547 no 248 0.0476697294309756 357 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_1863 st057641 20.1 µM 1.66636514559572 0.0482241179067769 no 249 0.0478203542636795 356 3921635
SGTC_848 0368-0089 85.6 µM 1.66462806876065 0.0484003491826069 no 250 0.0479934909220031 345 762535
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.66284780415527 0.0485814960441956 no 251 0.0481714523849611 335 6312947
SGTC_891 0929-0073 133 µM 1.6585913474584 0.0490167999138795 no 252 0.0485990832553151 311 5603632
SGTC_3344 9148862 3.898 µM 1.65636582786301 0.0492456391345607 no 253 0.0488238784825096 325 4905352
SGTC_2486 5283202 22.39 µM 1.65505089842337 0.0493812472863546 no 254 0.0489570868780185 353 1377751
SGTC_1930 st074634 34.3 µM 1.65466600697614 0.0494209973409872 no 255 0.0489961330392519 364 684253 YOR116C RPO31
SGTC_377 3970-0964 33.1 µM 1.6510240610673 0.0497983885628383 no 256 0.0493668309517228 446 16481235
SGTC_1221 2958-7315 257 µM 1.64561487223122 0.0503631466594395 no 257 0.0499215376212481 351 4562705
SGTC_1955 wogonin 32.4 µM 1.64210460346518 0.050732366632483 no 258 0.0502841639138345 328 5281703 A flavanone.
SGTC_3141 9094609 49.47 µM 1.64195141474746 0.0507485284110995 no 259 0.0503000366683602 360 25236309 YDL196W YDL196W
SGTC_1035 k081-0041 55.2 µM 1.64059590692861 0.0508917164632644 no 260 0.0504406626029275 367 731709
SGTC_1857 st056007 79.3 µM 1.63923495008918 0.0510358035123502 no 261 0.05058216880975 301 619834
SGTC_3266 9136860 49.47 µM 1.63378928424434 0.0516155978850725 no 262 0.0511515515709619 355 4871271 YPR165W RHO1
SGTC_1785 bathophenanthroline 24 µM 1.63321531718507 0.0516770114135092 no 263 0.0512118598030401 401 72812 An iron chelator.
SGTC_2731 amoxapine 43.43 µM 1.63243898680763 0.0517601698878167 no 264 0.0512935208762469 175 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_2596 sinensetin 100 µM 1.63200487237157 0.0518067174359714 no 265 0.0513392298866688 349 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_2044 5102272 200 µM 1.62081195731946 0.0530183955106893 no 266 0.0525289866460287 310 592666
SGTC_2286 7945697 125 µM 1.61702911722013 0.0534329473397679 no 267 0.05293599794057 404 1245733
SGTC_3288 9119690 36.221 µM 1.61416030109951 0.0537490429114949 no 268 0.0532463302250818 320 17595618 YKL019W RAM2
SGTC_2497 7-hydroxyflavone 100 µM 1.60885433778913 0.0543375722139571 no 269 0.0538240980146074 334 5281894
SGTC_2540 epiandrosterone 100 µM 1.60697399661517 0.0545473560718784 no 270 0.0540300362366217 503 441302 A steroid.
SGTC_2806 7952793 58.44 µM 1.60145474815015 0.0551668222291977 no 271 0.0546381175244093 372 2972490
SGTC_761 k216-0224 480 µM 1.60125830755418 0.0551889722069268 no 272 0.054659859618029 383 1340404
SGTC_1737 st035557 69.7 µM 1.59917279249201 0.0554245612520114 no 273 0.0548911069831602 313 5716916
SGTC_2908 7930301 100 µM 1.59567938045988 0.0558209708786888 no 274 0.0552801972644325 408 2223178
SGTC_1339 1486-1321 22.7 µM 1.59099442850765 0.0563560963763274 no 275 0.0558054148195042 381 3469382
SGTC_691 1548-0686 185 µM 1.58925392093981 0.0565559280945636 no 276 0.0560015386542269 411 46495133
SGTC_2227 7312221 64.1025 µM 1.58579847217905 0.0569543104147033 no 277 0.0563925161981237 294 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3150 9097574 49.47 µM 1.57638343413786 0.0580509968379392 no 278 0.0574687318997995 318 17217476
SGTC_1663 st014140 55.4 µM 1.57614002133144 0.0580795686811051 no 279 0.0574967687506633 434 4207120
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 1.57172729082208 0.0585994541834352 no 280 0.0580069050932811 419 688664
SGTC_325 2810-4341 181 µM 1.56720437927562 0.0591361049274527 no 281 0.0585334635862693 350 774970
SGTC_403 arphamenine a 50 µM 1.56270882581504 0.0596733217647946 no 282 0.0590605487679234 404 5487158 An arginine aminopeptidase inhibitor.
SGTC_436 n,n-dimethylsphingosine 3.3 µM 1.56237423965065 0.059713457076999 no 283 0.0590999260042358 399 5282309
SGTC_2737 bleomycin 30.5 nM 1.56025811784307 0.0599677867451838 no 284 0.0593494482284862 452 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2475 5812728 15.03 µM 1.55904058612348 0.0601145018545988 no 285 0.0594933872016642 417 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_637 1181-0519 7.26 µM 1.55819316354567 0.0602167838111676 no 286 0.0595937325489972 518 6252091 YGR060W ERG25
SGTC_710 3448-4187 58 µM 1.5555066887567 0.0605419358083317 no 287 0.0599127214070535 493 3946412
SGTC_2519 cryptotanshinone 88.04 µM 1.55004723812977 0.0612069399530043 no 288 0.0605650892088473 336 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_484 loperamide 105 µM 1.54836032866148 0.0614135690858707 no 289 0.0607677834958038 259 3955 An opioid-receptor agonist.
SGTC_43 0570-0105 72.5 µM 1.54285034516711 0.0620922837879786 no 290 0.0614335454640065 530 1114046 YDL195W SEC31
SGTC_3190 9110366 49.47 µM 1.53159555581875 0.0634968107456676 no 291 0.0628111349450867 329 17123768
SGTC_2015 5119600 184 µM 1.53113629469783 0.0635546444359652 no 292 0.062867855667538 400 2828786
SGTC_1099 5-nonyloxytryptamine 2.85 µM 1.5297083027302 0.0637347300577646 no 293 0.0630444737884112 407 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_123 0083-0120 66.675 µM 1.52830726439326 0.0639118020782514 no 294 0.0632181335662024 417 16001701
SGTC_934 2950-0684 338 µM 1.52514547028689 0.0643128152597889 no 295 0.0636114090022419 431 1121253
SGTC_2241 6772625 37.8075 µM 1.51857861289821 0.0651519411825342 no 296 0.0644342989445555 408 2285411
SGTC_1349 flufenamic acid 69 µM 1.51511057485054 0.0655985090333571 no 297 0.0648722020505054 377 3371 A non-steroidal anti-inflammatory.
SGTC_763 3453-1109 128 µM 1.51467067623919 0.0656553225371113 no 298 0.0649279120104571 424 1560353
SGTC_2307 7538926 6.34 µM 1.51113189221056 0.0661137500856823 no 299 0.0653774253113062 441 96582
SGTC_1597 7-benzyloxygramine 47.5 µM 1.5100437732688 0.0662552064696907 no 300 0.0655161275506935 582 260807
SGTC_2146 5545642 200 µM 1.508755604298 0.0664229724033663 no 301 0.0656806249781461 396 825326
SGTC_2136 5328288 199.296 µM 1.50706136625521 0.0666441236709653 no 302 0.0658974641652647 340 262395
SGTC_957 1187-1561 14.1 µM 1.50664930879395 0.0666979961661555 no 303 0.065950285637564 445 1538454
SGTC_2352 9027995 87.8 µM 1.50493824177388 0.0669220620881811 no 304 0.0661699776490685 352 2997347
SGTC_2602 kawain 100 µM 1.50304376717535 0.0671708241869037 no 305 0.0664138790397629 471 5369129
SGTC_3117 9124945 49.47 µM 1.50107938896734 0.0674295197195762 no 306 0.0666675145449016 351 17592065
SGTC_2813 7971799 71.43 µM 1.49888296586327 0.0677196851257808 no 307 0.0669519980877906 392 2234054
SGTC_1628 st004252 77.7 µM 1.48226992639289 0.0699457356442855 no 308 0.069134243480639 451 692968
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.48041417177847 0.0701978520186659 no 309 0.0693813751323545 398 2346 DNA damaging agent; causes G2/M arrest.
SGTC_2031 5180455 200 µM 1.47718501890174 0.0706382189925517 no 310 0.0698130242262076 384 29949
SGTC_732 3970-1727 52.7 µM 1.47640284010157 0.0707452052532578 no 311 0.0699178903684336 401 1275699
SGTC_3236 9132701 49.47 µM 1.47576436361369 0.070832628202241 no 312 0.0700035802660432 414 24282524
SGTC_1419 3993-2473 62.6 µM 1.47423058364616 0.0710429791173885 no 313 0.0702097589814056 433 704026
SGTC_1788 fluconazole 20 µM 1.46878780572861 0.0717933044328382 no 314 0.0709451762910365 435 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_2533 agelasine 13.65 µM 1.46759502850553 0.0719585462421928 no 315 0.0711071296173564 471 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_910 3454-3003 490 µM 1.46651565420042 0.0721083289461913 no 316 0.0712539298411334 469 820824
SGTC_1711 st032263 62.8 µM 1.46313095640162 0.0725795669195563 no 317 0.0717157743440242 425 3958979
SGTC_2097 5376186 200 µM 1.46248033466892 0.0726704200692991 no 318 0.0718048147018932 457 742755
SGTC_2512 diallyl trisulfide 49.23 µM 1.46139346357626 0.0728223855345643 no 319 0.0719537467373996 372 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_1219 1469-0211 33.1 µM 1.45997229492833 0.0730214591302638 no 320 0.0721488441779623 414 6822282
SGTC_513 4245-1575 41.7 µM 1.45977469019533 0.0730491720362904 no 321 0.0721760033522093 609 719745
SGTC_148 3253-0744 288.01 µM 1.45868115004405 0.0732026801794826 no 322 0.0723264433049127 413 6893655
SGTC_1511 0906-3109 28.5 µM 1.45635970762722 0.0735293758138749 no 323 0.0726466039295626 558 2882180
SGTC_3188 9110789 49.47 µM 1.45547721042425 0.0736538613372586 no 324 0.0727685974391027 461 849217
SGTC_2071 5230951 39.92 µM 1.45137216586289 0.0742350398737327 no 325 0.0733381280107735 468 1799272
SGTC_1087 pterostilbene 9.05 µM 1.45040162845945 0.0743729558759068 no 326 0.0734732766302938 482 5281727 Similar to reservatol, lowers cholesterol.
SGTC_332 4112-0506 40.9 µM 1.44961178476717 0.0744853391331998 no 327 0.0735834039159177 445 2790355
SGTC_85 0868-0259 160.055 µM 1.44590559342252 0.0750144081824315 no 328 0.0741018414362997 430 83173
SGTC_307 1501-1223 22.3 µM 1.44480070273779 0.0751726876791074 no 329 0.0742569368255386 442 2830329
SGTC_510 ag-490 170 µM 1.44477281601022 0.0751766858434852 no 330 0.0742608545380404 461 5328779
SGTC_2794 7785382 27.27 µM 1.44219292951247 0.0755472700430932 no 331 0.0746239773308133 536 2205081
SGTC_2515 chrysin 20.77 µM 1.44180867200529 0.0756025850754878 no 332 0.0746781778906895 446 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_482 fipronil 114 µM 1.43905362640037 0.0760000863760619 no 333 0.0750676647525218 339 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_3332 9141069 11.198 µM 1.43621646441091 0.0764110965818528 no 334 0.0754703777304975 402 17332883
SGTC_3240 9133527 49.47 µM 1.43437611025275 0.0766786054378966 no 335 0.0757324806396114 448 17617455
SGTC_1572 epiandrosterone 68.9 µM 1.43217677289863 0.0769992285527916 no 336 0.0760466186433156 489 441302 A steroid.
SGTC_1417 3966-0327 90.4 µM 1.43199071750887 0.0770263986983348 no 337 0.0760732389401969 504 651118
SGTC_2498 4'-Methoxychalcone 54.63 µM 1.42959096004037 0.0773774948163089 no 338 0.0764172258013557 453 641818 YHR062C RPP1
SGTC_73 0327-0325 16.231 µM 1.42876098235277 0.0774992070503909 no 339 0.0765364717715661 528 53298
SGTC_1316 1272-0050 65.9 µM 1.42843902964643 0.0775464589817703 no 340 0.0765827659928382 449 7340392
SGTC_2571 chrysanthemic acid 100 µM 1.4262609835351 0.0778666983606379 no 341 0.0768965111722357 427 2743 An insecticide.
SGTC_117 lucigenin 22.078 µM 1.42593260999374 0.0779150662497615 no 342 0.0769438976657225 528 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_1698 5-fluorocytosine 1.055 µM 1.42576007902314 0.0779404883905676 no 343 0.0769688039294974 424 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1050 3232-1156 69.3 µM 1.42539013139837 0.0779950207515047 no 344 0.0770222295664404 475 700529
SGTC_408 cantharidin 100 µM 1.42258878878057 0.0784088943689468 no 345 0.0774276979490807 495 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_1934 st074720 32.6 µM 1.41594242420863 0.0793974954188448 no 346 0.0783961812166868 535 17250992
SGTC_990 3985-0011 41.3 µM 1.41408380064624 0.0796756338583364 no 347 0.0786686494492137 421 5399565 YGL099W LSG1
SGTC_1849 st056239 19.2 µM 1.41276883071351 0.0798728606710011 no 348 0.078861852873034 490 5393181
SGTC_3010 9080089 71.4286 µM 1.41088221016733 0.0801564715162588 no 349 0.0791396742562454 456 17027233
SGTC_3333 9141820 12.094 µM 1.40960913955831 0.0803482786662888 no 350 0.0793275634070364 426 1939433
SGTC_1460 k062-0059 9.15 µM 1.40720891596783 0.0807108513446199 no 351 0.0796827242916328 457 1373085
SGTC_380 3970-0968 6 µM 1.40541413924559 0.0809827728517902 no 352 0.0799490823389292 453 2891601
SGTC_1048 3161-0300 24.5 µM 1.39880258837561 0.0819904372777484 no 353 0.0809360949576267 517 2165101
SGTC_3061 glucosamine 200 µM 1.39668271102555 0.0823155191851429 no 354 0.0812545027414067 446 91431 and experimental redox chemotherapeutic
SGTC_2459 5811157 9.22 µM 1.39044070233614 0.0832783638942516 no 355 0.0821975469816093 468 2870684 YBR192W RIM2
SGTC_3017 9080681 49.47 µM 1.38775631976533 0.0836950303197307 no 356 0.0826056299202377 463 16451914
SGTC_820 1582-0060 59.9 µM 1.38478218266775 0.084158498764635 no 357 0.0830595403161594 507 3848840
SGTC_1483 3453-0561 55.9 µM 1.38457658868739 0.0841906081233878 no 358 0.0830909870845066 544 4546991
SGTC_1554 st069299 38.7 µM 1.38449883183379 0.0842027544681633 no 359 0.0831028827706793 497 24207999
SGTC_2869 9037858 32.47 µM 1.38424611802844 0.08424223980261 no 360 0.0831415532128042 423 27187042
SGTC_1774 st048371 48.465 µM 1.38071087800451 0.0847960621675586 no 361 0.0836839376359809 512 4242727
SGTC_1214 0358-0031 63.7 µM 1.37556493557836 0.0856070862204588 no 362 0.084478184415695 504 4301366
SGTC_3040 9091894 49.47 µM 1.37526916531673 0.0856538768690181 no 363 0.0845240061464192 430 25236966
SGTC_926 2268-1401 59.4 µM 1.37422816170032 0.0858187152130568 no 364 0.0846854302532795 505 2931578
SGTC_1668 st014914 51.6 µM 1.37294991334679 0.0860214448532159 no 365 0.0848839590281242 453 2839556
SGTC_1515 3460-0031 42.1 µM 1.37229919852984 0.0861247854820271 no 366 0.0849851575219537 415 2876596
SGTC_1118 chelidonine 707.474 nM 1.37224838727448 0.0861328587724958 no 367 0.0849930634406245 541 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_396 dithiazanine 1.25 µM 1.37020929011286 0.0864573139340777 no 368 0.0853107895677699 455 10578 An antihelmenthic.
SGTC_1798 st045719 60.953 µM 1.36925907400432 0.0866088212948467 no 369 0.0854591530281264 438 3980186
SGTC_176 1486-1328 72.834 µM 1.36823862153247 0.0867717484068535 no 370 0.0856186980591156 539 22310231
SGTC_1094 duloxetine 25.4 µM 1.36620665186415 0.0870968579153676 no 371 0.0859370551336678 510 60834 A selective serotonin reuptake inhibitor.
SGTC_3207 9114163 49.47 µM 1.36266907399727 0.087665029707898 no 372 0.0864934143336343 567 849233
SGTC_813 k007-0158 173 µM 1.3593679102127 0.0881977210103547 no 373 0.0870150172142141 585 6523916
SGTC_308 4092-1169 104 µM 1.35627103778357 0.0886996368416426 no 374 0.087506473467614 541 2268590 YDL196W YDL196W
SGTC_1462 k081-0014 26.5 µM 1.35251144629363 0.0893118157990392 no 375 0.0881058798028498 357 3270634
SGTC_991 3996-0057 64.7 µM 1.35047690941383 0.0896444099752323 no 376 0.0884315277390352 507 715343
SGTC_2797 7859098 81.82 µM 1.35001936007787 0.089719334141288 no 377 0.088504886444273 524 972681
SGTC_3254 9136651 49.47 µM 1.34694563705265 0.0902238666190116 no 378 0.0889988709155999 538 16454030
SGTC_119 0121-0043 24.815 µM 1.34503780926078 0.0905380828661381 no 379 0.0893065124705417 688 1092378
SGTC_197 4544-0043 41.561 µM 1.34360787043088 0.0907741236525274 no 380 0.0895376115497186 559 896523
SGTC_2713 st079149 53.4 µM 1.34320840352867 0.0908401454062805 no 381 0.0896022506615981 550 3103253
SGTC_2149 5554786 194.827 µM 1.34312217656594 0.0908544012119238 no 382 0.0896162078949012 558 745063 YPR165W RHO1
SGTC_536 3852-0578 10.6 µM 1.3429785148597 0.0908781563249285 no 383 0.0896394654638554 518 2869208
SGTC_834 0312-0008 75.7 µM 1.33388459526768 0.0923912714494535 no 384 0.0911208404386037 560 6385573 YIL048W NEO1
SGTC_2328 6201408 200 µM 1.33045674718886 0.0929664346521407 no 385 0.0916839141008787 511 2890418
SGTC_527 4476-4215 268 µM 1.32641752043217 0.0936475739620826 no 386 0.0923507192901571 535 4418754
SGTC_1330 1469-0054 61.8 µM 1.32590692058057 0.0937339386517266 no 387 0.092435265189269 528 7102664
SGTC_2314 7727897 200 µM 1.32483145197354 0.0939160396019145 no 388 0.0926135302454509 501 900724
SGTC_125 0133-0007 11.75 µM 1.32378194898818 0.0940939955772686 no 389 0.0927877363952238 548 26541
SGTC_2975 9084847 53.72 µM 1.32316205279242 0.0941992233078589 no 390 0.0928907462280578 534 27211724
SGTC_232 clozapine 119 µM 1.32078646856616 0.0946032838637215 no 391 0.093286286396546 523 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_2028 5153890 36.43 µM 1.320190911095 0.0947047815963507 no 392 0.0933856428755727 526 2830968 YPR165W RHO1
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 1.31957757526178 0.0948093930648767 no 393 0.0934880469917213 576 5379071
SGTC_3279 9140807 49.47 µM 1.31951429602061 0.0948201909098501 no 394 0.0934986169733356 513 45595718
SGTC_2222 6885208 172.143 µM 1.31911298004332 0.0948886917747865 no 395 0.0935656721843022 467 609514
SGTC_909 3448-9333 149 µM 1.31686971634575 0.095272267427032 no 396 0.0939411495218613 510 3344074
SGTC_405 ebelactone b 50 µM 1.31620929146308 0.0953854107098093 no 397 0.0940519029914956 540 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_100 0086-0128 49.5915 µM 1.31369835878753 0.0958164839594753 no 398 0.0944738667475473 604 93297
SGTC_1867 st057372 64 µM 1.31148316018099 0.0961979743315641 no 399 0.0948472897031535 545 688837
SGTC_2168 5727979 200 µM 1.30431980459149 0.0974392532905661 no 400 0.0960622827709248 491 695210
SGTC_2191 5911152 200 µM 1.30340164785286 0.0975991987016045 no 401 0.0962188371171593 523 2875902
SGTC_433 pimozide 108 µM 1.30195552220593 0.0978515080270325 no 402 0.0964657953121579 425 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_721 1187-1332 279 µM 1.30082627579803 0.0980488627847759 no 403 0.0966589629035352 448 25730
SGTC_1965 Pectolinarigenin 58.4 µM 1.3000072656927 0.0981921809081715 no 404 0.0967992394799623 543 5320438 An anti-inflammatory.
SGTC_3122 9126309 49.47 µM 1.29867699694642 0.0984252908515735 no 405 0.0970274007710972 509 17591206
SGTC_2482 5981709 142.65 µM 1.2959215965711 0.0989094225243698 no 406 0.0975012489572382 589 877755
SGTC_1784 st039334 36.3 µM 1.29466439651874 0.0991308940509665 no 407 0.0977180135382613 548 3496984
SGTC_1328 1441-0025 69.2 µM 1.29384403332874 0.0992756067070038 no 408 0.0978596497181246 495 4562601
SGTC_485 niflumic acid 177 µM 1.29280939601578 0.0994583376393525 no 409 0.0980384949353243 514 4488 A COX2 inhibitor.
SGTC_889 0919-1524 82.7 µM 1.292586749622 0.0994976921250526 no 410 0.0980770124147489 517 3905452
SGTC_2289 7946404 165.07 µM 1.29157847872849 0.0996760543434636 no 411 0.0982515805124659 641 1246120 YPR165W RHO1
SGTC_1518 st038567 90.8 µM 1.29064119018689 0.0998420692684001 no 412 0.09841406302254 506 77966
SGTC_2732 terfenadine 20 µM 1.28785279146826 0.100337151546649 no 413 0.098898605719713 482 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1870 st057514 26.5 µM 1.28691114264085 0.100504746013963 no 414 0.0990626305362827 552 5393161
SGTC_3356 9151811 4.48 µM 1.2818582892925 0.101407540987159 no 415 0.0999461810730508 566 1859254 YPR165W RHO1
SGTC_2185 6113692 200 µM 1.28149549386683 0.101472588335084 no 416 0.100009840839484 504 874150
SGTC_2706 st078239 82.5 µM 1.28008823187753 0.10172519071678 no 417 0.100257053481622 556 15434492
SGTC_2421 5690543 90.72 µM 1.27994935748403 0.10175014335353 no 418 0.100281473599375 561 3397993
SGTC_142 0335-0849 62.6745 µM 1.27890193961892 0.101938484577529 no 419 0.100465794771956 684 3889043 YPR107C YTH1
SGTC_2653 dihydrofissinolide 100 µM 1.27730313264554 0.102226462729418 no 420 0.10074762404597 526 6857746
SGTC_460 trequinsin 123 µM 1.27664512882281 0.102345154538471 no 421 0.100863780817084 590 5537 A vasodilator.
SGTC_1461 k072-0203 53.8 µM 1.27624381854878 0.102417592727778 no 422 0.100934671648116 537 5418714
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM 1.27019500231926 0.10351394854677 no 423 0.102007588713571 550 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1148 3909-7663 27.7 µM 1.26658432278285 0.104172435164295 no 424 0.102651980496889 572 4084526
SGTC_788 1182-0090 188 µM 1.26103905833312 0.1051896401363 no 425 0.103647387625147 704 5715185
SGTC_1910 st062352 60.4 µM 1.25905927938414 0.105554539727833 no 426 0.10400446056861 569 2245730
SGTC_2422 chlorphenesin carbamate 384.24 µM 1.25875671729983 0.105610386484114 no 427 0.104059109151776 604 2724 A muscle relaxant with antifungal properties.
SGTC_1457 k015-0032 57.3 µM 1.25726533337777 0.105885977595894 no 428 0.104328786280923 579 4302660
SGTC_558 k064-0027 21.3 µM 1.25716108990159 0.105905260043913 no 429 0.104347654863048 582 5088526
SGTC_3205 9113483 49.47 µM 1.25652610634687 0.106022771006224 no 430 0.104462643424979 618 17018033
SGTC_402 epigallocatechin gallate 10 µM 1.25642538348812 0.106041419576274 no 431 0.104480891664133 604 65064 An antioxidant.
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.25448860871496 0.106400469330926 no 432 0.104832231800195 680 368090
SGTC_2425 5628681 7.85 µM 1.25304796743722 0.106668111947114 no 433 0.105094125234405 669 5714958
SGTC_82 0054-0107 293.755 µM 1.25013834207595 0.107210143700746 no 434 0.105624507797939 567 3104697
SGTC_621 3584-0052 32.1 µM 1.2493051683425 0.107365720104968 no 435 0.105776739152676 603 2273927
SGTC_606 k015-0008 38.6 µM 1.24711993460355 0.107774536233036 no 436 0.106176762281364 635 1970475
SGTC_2948 9070189 9.45 µM 1.24585120983841 0.108012404656515 no 437 0.106409512514101 524 6473636 YDL196W YDL196W
SGTC_1828 st055811 49 µM 1.2402410834271 0.109068757570452 no 438 0.107443118425104 532 5877589
SGTC_642 0335-0876 158 µM 1.2390366742065 0.109296505405952 no 439 0.107665958347442 600 6812350
SGTC_1433 4060-0023 7.6 µM 1.23761677747309 0.109565439426118 no 440 0.107929095238911 609 3840627
SGTC_1571 st070080 73.4 µM 1.23701691561519 0.109679198279894 no 441 0.108040401373822 586 4315245
SGTC_3054 9094397 49.47 µM 1.23676642781919 0.109726726313026 no 442 0.108086904575578 623 2598354
SGTC_570 0987-0065 62.6 µM 1.23646472988881 0.10978399068038 no 443 0.108142934096443 477 3104428
SGTC_704 1310-0270 142 µM 1.23396442487475 0.110259391650134 no 444 0.108608080446183 615 5718033
SGTC_3338 9144300 39.5675 µM 1.23378540017282 0.110293487458136 no 445 0.108641440580826 610 4901274
SGTC_341 1486-1430 230 µM 1.23369402408049 0.110310893231731 no 446 0.108658470785289 593 2054753 YPL210C SRP72
SGTC_2778 tioconazole 65.09 nM 1.23358182377513 0.110332268399477 no 447 0.1086793847252 612 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_850 0388-0143 75.9 µM 1.23140866659851 0.110746860401526 no 448 0.109085028597762 580 67273
SGTC_2110 5483698 200 µM 1.22986428177408 0.111042173850971 no 449 0.10937396580551 589 2848765 YHR062C RPP1
SGTC_178 4092-0806 87.505 µM 1.22466146917683 0.112041192078833 no 450 0.110351398658954 686 2169044
SGTC_1378 2093-0007 380 nM 1.22168742551436 0.112615131280422 no 451 0.110912926633276 607 3618014
SGTC_643 k048-0106 28.4 µM 1.2215364602332 0.11264432087549 no 452 0.110941484815336 610 6763920
SGTC_1804 st050076 49.1 µM 1.219466841367 0.113045032847496 no 453 0.111333526887536 615 3895976
SGTC_2537 larixol 68.93 µM 1.21940438097494 0.113057141991995 no 454 0.111345373980178 665 6708759
SGTC_2208 7283366 200 µM 1.21683625482944 0.113555824178781 no 455 0.111833261472616 622 898663
SGTC_2702 st077768 96.8 µM 1.21649492203658 0.113622222534927 no 456 0.111898222130647 546 6484119
SGTC_3337 9144342 33.5465 µM 1.21368445373394 0.114169986133497 no 457 0.112434121582144 611 17682949
SGTC_995 3931-2021 34.6 µM 1.21152128882937 0.114592868565093 no 458 0.112847840317051 582 730143
SGTC_2056 5235370 200 µM 1.21105012177269 0.114685125832106 no 459 0.112938097903804 597 5511916
SGTC_1274 0865-0114 173 µM 1.21005616433533 0.114879921837552 no 460 0.11312867111206 609 870624
SGTC_3177 9107506 49.47 µM 1.20905015964543 0.115077318400647 no 461 0.1133217876969 558 8897194
SGTC_138 0850-0259 40.9225 µM 1.20896499910851 0.115094039525138 no 462 0.113338146234662 734 6813004
SGTC_1063 disulfiram 1.84 µM 1.19930584138339 0.117001821764348 no 463 0.115204522291611 613 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2370 9071495 200 µM 1.19912342128217 0.11703806592826 no 464 0.115239979120791 587 21791103
SGTC_2114 5491910 81.25 µM 1.19584688000129 0.11769042115192 no 465 0.115878158865634 640 2849228
SGTC_657 3534-0529 86.7 µM 1.19140554722212 0.118578787270123 no 466 0.116747208145922 614 1049549
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 1.19131062068803 0.118597826287247 no 467 0.1167658330142 717 688664
SGTC_322 k048-0136 19.3 µM 1.18981934826695 0.118897208095772 no 468 0.117058701607895 599 6823282
SGTC_2054 5233173 129 µM 1.18974471402189 0.118912205376329 no 469 0.117073372571523 678 6889
SGTC_2544 sphondin 68.51 µM 1.18972825897211 0.118915512094479 no 470 0.117076607340206 597 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.1886459741095 0.119133144844509 no 471 0.117289504277645 648 688669
SGTC_2628 lathosterol 100 µM 1.188251033016 0.119212632102185 no 472 0.11736726163462 632 6710616
SGTC_2746 daunorubicin 9.88 µM 1.18824246607204 0.119214356730697 no 473 0.117368948728362 470 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_185 k048-0037 25.491 µM 1.18733554634718 0.119397030165336 no 474 0.117547646161723 668 6827589
SGTC_3057 9095946 49.47 µM 1.18720414979007 0.119423512672881 no 475 0.117573552211541 618 24540043
SGTC_1940 st075990 51.1 µM 1.18671919211 0.119521290039273 no 476 0.117669201102037 692 1084979
SGTC_2825 7998094 58.44 µM 1.18303262733581 0.120266423385535 no 477 0.11839810841611 609 2987815
SGTC_246 cycloheximide 667 µM 1.18215813900331 0.120443655333294 no 478 0.118571479538303 556 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2853 9015042 58.44 µM 1.18141261418119 0.120594895525497 no 479 0.11871942468393 583 6457456
SGTC_342 k048-0088 23.3 µM 1.18137063896162 0.120603414763416 no 480 0.11872775830291 620 6820570
SGTC_145 3737-0113 38.366 µM 1.18089337140707 0.120700310188358 no 481 0.118822542463066 739 6849351
SGTC_3277 9138724 49.47 µM 1.17312773496683 0.122284603201214 no 482 0.120372292931464 522 15943418
SGTC_2567 aureobasidin a 60 nM 1.17153697400065 0.122610932804689 no 483 0.120691502457112 647 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_449 xestospongin c 11.1929 µM 1.17113155492339 0.122694198306404 no 484 0.120772950945865 672 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_2926 9010726 65.15 µM 1.16581580302358 0.123789624942144 no 485 0.121844463226469 633 2994293
SGTC_137 0438-0332 85.389 µM 1.16513243837601 0.123930942239844 no 486 0.121982694077196 764 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_250 brefeldin a 552.239 µM 1.16313777927593 0.12434407603981 no 487 0.122386803094937 550 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_1549 4'-methoxyflavonol 74.6 µM 1.16277623931691 0.124419061187713 no 488 0.122460149943416 660 97141
SGTC_2034 5197015 53.07 µM 1.16204099637859 0.124571651676669 no 489 0.122609406331145 657 780676
SGTC_316 k060-0003 58.6 µM 1.16035344261579 0.124922376976832 no 490 0.122952466996527 639 6152314
SGTC_1964 st076914 61 µM 1.15959945701461 0.125079301009348 no 491 0.123105961086451 653 24208661
SGTC_210 3551-0445 56.827 µM 1.15663009242481 0.125698641604232 no 492 0.123711761113065 669 2865180 YOR207C RET1
SGTC_753 1322-0200 289 µM 1.15165598505515 0.126740912505261 no 493 0.12473123292679 672 5403907
SGTC_2266 7929956 200 µM 1.15113949583355 0.126849481158857 no 494 0.124837425854471 680 2967153
SGTC_1291 0993-0025 5.79 µM 1.14914918825959 0.127268459310664 no 495 0.125247234356295 683 4353356
SGTC_2563 tomatine 8.54 µM 1.14753843858233 0.127608241098682 no 496 0.125579578075438 728 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_3115 9123671 49.47 µM 1.14671718710006 0.127781723648296 no 497 0.125749262390559 679 3286988
SGTC_1181 1222-0449 220 µM 1.1461959882298 0.127891907563812 no 498 0.125857033734214 687 658318
SGTC_613 3914-0030 117 µM 1.14515387752883 0.128112412635907 no 499 0.126072710193403 414 1145395
SGTC_1387 3342-1166 1.8 µM 1.14456339203702 0.128237473359904 no 500 0.126195032068446 590 3418228
SGTC_1004 4084-0029 199 µM 1.14005913742484 0.129194233088835 no 501 0.127130832191763 713 716894 YLR208W SEC13
SGTC_45 0kpi-0036 14.9 µM 1.13745305103178 0.129750052524119 no 502 0.127674470275626 625 2795021
SGTC_1166 k206-0078 225 µM 1.13367897616657 0.130557909483407 no 503 0.128464615783613 711 5404595
SGTC_2833 9001315 45.46 µM 1.1260405140386 0.132203581461263 no 504 0.130074185535052 680 2989378
SGTC_3094 9117742 49.47 µM 1.12269727838176 0.132928346845446 no 505 0.130783042141886 718 17149698
SGTC_1812 st052057 4.327 µM 1.12245823823387 0.132980271896579 no 506 0.13083382722014 707 3645418
SGTC_406 estrone 100 µM 1.12217230094942 0.133042402430065 no 507 0.130894593691997 694 5870 A steroid.
SGTC_797 k781-0471 270 µM 1.1218866894175 0.133104482126143 no 508 0.130955310403982 713 23738129
SGTC_1160 4092-0570 10.5 µM 1.12009707384392 0.133493921617267 no 509 0.131336198726004 710 4994975
SGTC_233 rapamycin 362 pM 1.1187078546384 0.133796770350057 no 510 0.131632396591147 709 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_956 1185-0240 191 µM 1.11594951931184 0.134399484278048 no 511 0.132221871692607 672 1416193
SGTC_1082 camptothecin 424.86 nM 1.11271320331365 0.135109013536449 no 512 0.132915811556402 609 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM 1.11260685567317 0.135132372679729 no 513 0.132938657387435 734 6708561
SGTC_3113 9123498 49.47 µM 1.10866170613207 0.136000877691047 no 514 0.133788073769496 717 8897275
SGTC_205 1486-1330 71.903 µM 1.10798226683318 0.136150837738646 no 515 0.133934737226788 652 4118834
SGTC_2019 4016004 108 µM 1.1042217817585 0.136982866105085 no 516 0.134748471601432 629 45595336
SGTC_1456 k015-0012 13 µM 1.10374699390719 0.137088162084645 no 517 0.134851452011849 781 2989616
SGTC_2369 9071472 200 µM 1.10188042258949 0.137502656515364 no 518 0.135256830418208 714 17296037
SGTC_1763 st044482 94.5 µM 1.10115717157909 0.137663492780366 no 519 0.135414129029587 730 88505
SGTC_1408 3909-7976 48.8 µM 1.10090443672066 0.137719726115749 no 520 0.135469125444533 760 24152374
SGTC_599 1935-0052 86.5 µM 1.10024000343504 0.137867636840286 no 521 0.135613782577213 729 9557311
SGTC_3220 9131269 49.47 µM 1.09993549698025 0.137935459788393 no 522 0.135680113568186 696 17722206
SGTC_2359 9039622 200 µM 1.09600217368154 0.138813577613703 no 523 0.136538911612022 752 6463596
SGTC_1153 4055-0057 267 µM 1.09247331322097 0.139604632114498 no 524 0.137312557091424 730 882706
SGTC_1117 retinoic acid 1.10837 µM 1.08965340796907 0.140238961645304 no 525 0.137932923612389 778 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_453 enantio-paf c16 10 µM 1.08609215590955 0.141042848335596 no 526 0.138719111206285 842 13871343 A lipid and platelet activating factor
SGTC_3200 9114385 49.47 µM 1.08505220759727 0.141278185798001 no 527 0.138949266503213 665 17018030 YLR208W SEC13
SGTC_3134 9127454 49.47 µM 1.08402516459223 0.141510863939921 no 528 0.139176820708999 730 24262820
SGTC_120 rhodamine 6G 52.259 µM 1.083803238304 0.141561175772057 no 529 0.139226024553507 855 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_2834 9001755 58.44 µM 1.08342141554911 0.141647765316355 no 530 0.139310707152592 650 2989575
SGTC_633 0437-0093 97.7 µM 1.08219136109553 0.141926960295334 no 531 0.139583753174381 707 2831118
SGTC_1263 0774-1208 64.8 µM 1.07992707132715 0.14244187731433 no 532 0.140087328552411 804 906585
SGTC_1303 1160-0052 261 µM 1.07992685873224 0.142441925719309 no 533 0.140087375891145 723 3562476
SGTC_2828 7998861 71.43 µM 1.076738801252 0.143169054497991 no 534 0.140798486339176 633 2988188
SGTC_392 N-ethylmaleimide 8.33 µM 1.07629352653741 0.143270811481285 no 535 0.140898001437082 697 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3055 9094636 49.47 µM 1.07601014905676 0.143335596116488 no 536 0.140961358724923 688 25236176
SGTC_2945 9067681 61.76 µM 1.07259568445548 0.144117752612656 no 537 0.14172628093644 701 16456930
SGTC_2993 9054257 71.4286 µM 1.07143105511907 0.144385192976 no 538 0.141987827751332 721 6470217 YGL055W OLE1
SGTC_2351 9026858 72.31 µM 1.06696681091053 0.145413439212284 no 539 0.142993411619644 684 1409300
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM 1.06660547666413 0.145496880009259 no 540 0.143075013193524 711 6708514
SGTC_619 1652-1634 108 µM 1.06377759540215 0.146151018056745 no 541 0.14371473157272 688 5400454
SGTC_666 0272-0154 136 µM 1.06367660133973 0.14617441621415 no 542 0.143737613914782 759 6870312
SGTC_9 0092-0002 10.449 µM 1.06082259808529 0.146836667740347 no 543 0.144385265155477 758 759368
SGTC_256 clotrimazole 625 nM 1.0595469811636 0.147133315569894 no 544 0.144675372434386 723 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2137 5261020 140 µM 1.05759542409934 0.147587931998813 no 545 0.14511996479458 740 763655
SGTC_1031 k035-0009 16 µM 1.05668666664257 0.147799948367869 no 546 0.145327306070218 806 5180959
SGTC_2234 tolnaftate 200 µM 1.0560177195444 0.147956146371312 no 547 0.145480059717015 710 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_1646 st011709 75.6 µM 1.05585775478141 0.14799351423488 no 548 0.145516603562075 697 5757843
SGTC_327 1273-0057 3.96 µM 1.05277770811646 0.148714246752522 no 549 0.146221441991404 713 3108138
SGTC_211 3455-0679 143.504 µM 1.04862267505466 0.149690238066999 no 550 0.147175907741209 777 748649
SGTC_2283 7944793 200 µM 1.04593012610284 0.150324977863626 no 551 0.147796647022011 737 2970533
SGTC_62 0180-0423 3.232 µM 1.04570777177333 0.150377475587275 no 552 0.147847986757249 748 30102 YGL099W LSG1
SGTC_1402 3909-7673 35.9 µM 1.04323210426064 0.150962804296131 no 553 0.148420403962337 740 5328014
SGTC_1410 3909-8106 77.9 µM 1.04279545639843 0.151066199217695 no 554 0.148521518069952 747 1039210
SGTC_819 1013-0258 27.7 µM 1.04278881238082 0.151067772834839 no 555 0.14852305697413 752 5753198
SGTC_225 nsc-122657 1.016 µM 1.04080917699837 0.151537129801214 no 556 0.148982060028535 625 275685
SGTC_3099 9120367 49.47 µM 1.03602205259701 0.152676124495957 no 557 0.150095927250923 764 24824940
SGTC_1132 3456-3614 2.5 µM 1.03372996583468 0.153223483273581 no 558 0.150631210067663 869 3125502
SGTC_150 3970-0969 77.2 µM 1.03343011939349 0.153295183772393 no 559 0.150701328667779 816 6615640
SGTC_3033 9090887 49.47 µM 1.03062393076658 0.153967288420268 no 560 0.151358604705516 782 19325384
SGTC_2580 diallyl disulphide 81.36 µM 1.03028551432677 0.154048473421257 no 561 0.151437998499757 720 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_2994 9053520 71.4286 µM 1.02838204715082 0.15450563655401 no 562 0.151885075031235 778 4647384
SGTC_1829 berberine 14.4 µM 1.02802940843367 0.154590429529265 no 563 0.15196799716553 772 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_795 0685-0265 78 µM 1.02791995993267 0.154616752983157 no 564 0.151993739827624 803 302754
SGTC_2846 9008642 19.48 µM 1.02648352924837 0.154962503402597 no 565 0.15233186169456 710 2992898
SGTC_69 0096-0274 206.684 µM 1.02566209935922 0.155160451777837 no 566 0.152525442562449 847 6741392
SGTC_430 0958-0115 16.4 µM 1.02393879016565 0.155576277478172 no 567 0.152932093499264 741 6833180
SGTC_122 0236-0016 402.397 µM 1.02248450740405 0.155927759875034 no 568 0.153275820775928 842 6808838
SGTC_2284 7945075 39.21 µM 1.0213631409412 0.156199137608328 no 569 0.153541210816384 871 1245402
SGTC_791 1348-1292 225 µM 1.01987395741065 0.156560010114151 no 570 0.153894121019286 873 5437054
SGTC_2664 lyso-paf C-16 73.48 µM 1.01977115140668 0.156584943239564 no 571 0.153918504020094 816 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_382 3229-0966 23.2 µM 1.01799007959257 0.157017314328106 no 572 0.154341335295067 821 5722370
SGTC_917 harmaline 728.087 nM 1.01784309759089 0.157053030566525 no 573 0.154376263494789 778 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_3318 9139014 38.6185 µM 1.01577514047705 0.157556105124716 no 574 0.154868238335287 749 16643984
SGTC_3067 9117431 49.47 µM 1.00961197975559 0.159061698743973 no 575 0.156340613910496 744 17150885
SGTC_2904 7225135 42.03 µM 1.00840189842908 0.159358411956496 no 576 0.15663078096718 849 4446116
SGTC_2085 5307070 144.047 µM 1.00630645973815 0.159873072319041 no 577 0.157134087029014 743 2840351
SGTC_194 1486-1323 56.904 µM 1.00516896064577 0.160152908071996 no 578 0.15740774927017 776 5178754
SGTC_2305 7443522 69.23 µM 1.00495433748983 0.160205743326797 no 579 0.15745941892876 843 5415886
SGTC_724 3910-0327 137 µM 1.00216699106406 0.160892958278876 no 580 0.158131473662362 802 2885483
SGTC_2333 9017922 200 µM 1.00112276727604 0.161150904434123 no 581 0.158383729635091 797 3163164
SGTC_2236 dapsone 200 µM 1.00066644111972 0.161263711666465 no 582 0.15849404842576 851 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_1086 cerivastatin 2.18 µM 1.00008403118964 0.161407762556973 no 583 0.158634921697924 770 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_3181 9108277 49.47 µM 0.99880133891655 0.16172531424159 no 584 0.158945468652595 778 17097298
SGTC_3148 9097893 49.47 µM 0.995861099632321 0.162454754373848 no 585 0.15965881918551 748 17174100
SGTC_2075 5212009 200 µM 0.99504394570874 0.162657860654298 no 586 0.159857445666724 717 780898
SGTC_680 0417-1641 114 µM 0.992231025236162 0.163358283676935 no 587 0.160542420620008 764 2835990
SGTC_865 0488-0499 301 µM 0.990359783274327 0.163825310402387 no 588 0.160999147609464 875 9634651
SGTC_584 0986-0246 15.4 µM 0.989429047768823 0.16405792682104 no 589 0.161226634162438 889 53315 YDR232W HEM1
SGTC_347 4534-1311 26.2 µM 0.989380339862976 0.164070106164324 no 590 0.161238544920105 790 2862016
SGTC_3121 9125696 49.47 µM 0.988718731838887 0.16423559840899 no 591 0.161400387680034 825 1235365
SGTC_833 3852-0053 558 µM 0.986021407956034 0.16491141711964 no 592 0.162061303869124 888 3123681
SGTC_2980 9014342 25.29 µM 0.983460134646458 0.165554812731197 no 593 0.162690513240733 759 2996599
SGTC_3321 9137793 26.8275 µM 0.981412660488718 0.166070307309441 no 594 0.163194642658985 826 4904192
SGTC_76 0433-0009 400.328 µM 0.98137177241723 0.166080612290128 no 595 0.163204720454053 727 2841569
SGTC_2408 sulbentine 18.36 µM 0.981306969922964 0.166096945245646 no 596 0.1632206933308 807 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_1468 k284-1086 134 µM 0.980633784171716 0.166266677765403 no 597 0.163386683957674 878 15996457
SGTC_368 fentichlor 4.58 µM 0.978550830824043 0.166792568858218 no 598 0.163900982006715 733 7329 A pesticide.
SGTC_2321 7390090 138.78 µM 0.977989525035767 0.166934467208117 no 599 0.164039752442939 733 649046
SGTC_1912 st060209 90.8 µM 0.976495955644881 0.167312421319631 no 600 0.16440937555644 770 688787
SGTC_2831 7999036 19.48 µM 0.9762288746502 0.167380065388894 no 601 0.164475528649455 874 2988270
SGTC_931 2812-0076 566 µM 0.975991683184051 0.167440154058456 no 602 0.164534292890088 833 3450959
SGTC_2777 climbazole 1.536 µM 0.973929894562889 0.167963060692072 no 603 0.165045674619637 859 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_1864 st057645 30.4 µM 0.971788211535152 0.168507341714294 no 604 0.165577960837669 817 688666
SGTC_1512 0259-0544 12.2 µM 0.971313144269216 0.168628227408438 no 605 0.165696182636697 865 18476
SGTC_1010 4112-3296 15.2 µM 0.969356107233253 0.169126803009921 no 606 0.166183772060269 872 704384
SGTC_2576 guaiol 23.12 µM 0.969246809796684 0.16915467555306 no 607 0.166211030460795 890 227829
SGTC_641 4092-0595 30 µM 0.968978419475029 0.169223131764939 no 608 0.166277978325766 850 786260
SGTC_2386 9075165 157.42 µM 0.968028775892548 0.169465492677711 no 609 0.166514999289777 834 16452277
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 0.96607368439151 0.169965157410199 no 610 0.167003655741833 827 390807
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.964962283211928 0.170249619943907 no 611 0.167281851712828 787 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_2099 5377090 177.372 µM 0.963302210082578 0.170675082479434 no 612 0.167697942260146 815 2243829
SGTC_361 000s-0510 1.45 µM 0.961953529608192 0.171021238383476 no 613 0.168036473785456 813 660
SGTC_2808 7946468 45.46 µM 0.960438370846086 0.171410658313241 no 614 0.16841731713635 851 2970879
SGTC_2441 5730946 39.09 µM 0.957650176538588 0.172128748465038 no 615 0.16911959415878 863 1774275
SGTC_1012 4112-3522 18 µM 0.957340354913634 0.172208660350613 no 616 0.169197746467846 879 3112398
SGTC_1669 st015249 58.4 µM 0.956903209075163 0.172321453063806 no 617 0.169308055662063 907 722793
SGTC_1323 1348-1351 11.2 µM 0.956771083217513 0.172355553554979 no 618 0.169341405327485 806 6989654
SGTC_3245 9134821 49.47 µM 0.956099390289173 0.172528978000732 no 619 0.169511011406906 860 17014901
SGTC_2066 5222451 176 µM 0.955569419860312 0.172665889613963 no 620 0.169644908691242 893 2281147
SGTC_1997 st073024 93.8 µM 0.95391322338488 0.173094194760705 no 621 0.170063784691312 852 686268
SGTC_1820 st053765 18.6 µM 0.952398326281908 0.17348655086799 no 622 0.170447503988857 818 3690829
SGTC_3080 9117754 49.47 µM 0.947501032359495 0.174758811708678 no 623 0.171691765219162 922 9550191
SGTC_2481 5478948 45.16 µM 0.946138292270278 0.175113886661221 no 624 0.172039027534241 814 77792
SGTC_575 k072-0246 11.9 µM 0.944925244059648 0.175430342670615 no 625 0.172348521300657 876 6796779
SGTC_1477 0139-0234 16 µM 0.943495811486522 0.175803713299243 no 626 0.172713678352361 879 620880
SGTC_3077 9117319 49.47 µM 0.942602943684016 0.176037187350924 no 627 0.172942016796229 818 17154678
SGTC_2699 st077704 54.6 µM 0.94169913995648 0.176273720844859 no 628 0.173173347751374 843 645852
SGTC_923 1900-2434 73.3 µM 0.941208381450553 0.176402240934217 no 629 0.173299041205566 839 5910570
SGTC_615 k087-0205 167 µM 0.931122186667684 0.179056737931087 no 630 0.175895181549595 819 9642773
SGTC_3025 9087895 49.47 µM 0.929753778573109 0.17941880358743 no 631 0.176249291480785 932 17173641
SGTC_1901 st060216 58.6 µM 0.927364357769122 0.180052120556999 no 632 0.176868694868334 885 688792
SGTC_2393 9031399 185.94 µM 0.925369357250602 0.180581970034706 no 633 0.177386906262139 890 1526623 YDL150W RPC53
SGTC_2984 9022109 38.96 µM 0.923694930104622 0.181027432847022 no 634 0.177822586245548 869 6459207
SGTC_262 fenpropimorph 62.5 µM 0.91800532493783 0.182546227870734 no 635 0.179308039040283 831 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1362 1611-0397 101 µM 0.915732959002487 0.183155035481079 no 636 0.179903486854099 879 27816
SGTC_2529 gangaleoidin 93.61 µM 0.913313827785499 0.183804554219146 no 637 0.180538755937047 897 4565183
SGTC_955 1216-0110 33 µM 0.91318605226181 0.183838900842738 no 638 0.180572349139662 873 3619719
SGTC_1494 4358-1428 177 µM 0.912850792727784 0.183929039085576 no 639 0.180660510176519 932 1564571
SGTC_2201 6605497 169.863 µM 0.911746742877188 0.184226069633331 no 640 0.180951025788833 897 670741
SGTC_1103 duloxetine 36.1 µM 0.910557158156111 0.184546446154937 no 641 0.181264376193983 989 60835 A selective serotonin reuptake inhibitor.
SGTC_192 3455-0609 60.9 µM 0.910178832702024 0.184648408570284 no 642 0.181364102683812 899 3769639
SGTC_696 1560-0013 611 µM 0.909261306226833 0.184895836393235 no 643 0.18160610507176 901 1650269
SGTC_442 cape 100 µM 0.908678472499598 0.185053115145834 no 644 0.18175993540735 883 5281787
SGTC_20 0481-0013 4.944 µM 0.906361916480999 0.185679063361973 no 645 0.18237216163219 933 182045
SGTC_1850 st056238 17 µM 0.904305407458616 0.186235844519991 no 646 0.182916740126325 977 5393177
SGTC_1848 st056003 16.4 µM 0.903026332195246 0.186582663832664 no 647 0.183255959866155 982 146492
SGTC_1108 betulinic acid 729.144 nM 0.90086339386841 0.187170050520212 no 648 0.183830478237773 912 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_3002 9075603 71.4286 µM 0.900335004650131 0.187313718200181 no 649 0.183970998989039 954 20105405
SGTC_3087 9117406 49.47 µM 0.897064514230755 0.188204472377167 no 650 0.184842246391134 864 42546093
SGTC_77 0828-0286 12.516 µM 0.896299245769642 0.188413278447287 no 651 0.185046480916339 942 745345
SGTC_483 fpl-64176 144 µM 0.895741491442329 0.188565553572972 no 652 0.185195422445258 870 3423
SGTC_1370 2001-0092 44.6 µM 0.895721760969679 0.188570941671141 no 653 0.185200692591801 1014 790957
SGTC_2264 7948757 110.76 µM 0.895256041420039 0.188698150306322 no 654 0.185325116569322 878 2971411
SGTC_2866 9034245 58.44 µM 0.894904625957681 0.188794172439667 no 655 0.185419036840258 924 6462273
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.89462609184146 0.188870301577932 no 656 0.18549349962703 876 5282362
SGTC_984 1492-0255 2.91 µM 0.894019702571615 0.189036105719425 no 657 0.185655674770023 867 1585198
SGTC_1675 st018485 24.5 µM 0.891365352999694 0.189762935302797 no 658 0.186366599354074 910 3323024
SGTC_976 1348-1067 47.6 µM 0.889794319710584 0.190193933381067 no 659 0.186788168601003 1008 5310671 YGL099W LSG1
SGTC_1446 4239-0190 62 µM 0.88628253417904 0.191159531003808 no 660 0.187732649175602 951 1340085
SGTC_1801 st050089 28.441 µM 0.885500216258815 0.191375045154497 no 661 0.187943451512507 984 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_1989 st071868 50.2 µM 0.885317797980735 0.191425319423914 no 662 0.187992626700782 964 16414057
SGTC_2809 7964133 12.99 µM 0.885005028066854 0.191511537286865 no 663 0.188076959757764 901 1253665
SGTC_736 0958-0254 92.6 µM 0.884493085104049 0.191652710336732 no 664 0.18821504680121 957 6812352
SGTC_2376 9072922 81.32 µM 0.884466840410106 0.191659949273089 no 665 0.188222127502093 936 17087968
SGTC_507 nimesulide 162 µM 0.883979453955226 0.191794412953632 no 666 0.188353652052312 940 4495 A COX2 inhibitor.
SGTC_1425 4048-4433 7.33 µM 0.880803325929154 0.192672079889276 no 667 0.189212139640992 987 23734946
SGTC_1165 k072-0275 30.3 µM 0.88061151254973 0.192725162602451 no 668 0.189264062628143 942 6153523 YGL055W OLE1
SGTC_2697 mebhydrolin 72.4 µM 0.88051533452499 0.192751782412059 no 669 0.189290100872494 959 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.880155917769568 0.192851280378232 no 670 0.189387425167723 912 4330530
SGTC_2752 diclazuril 33.15 µM 0.879358940732916 0.193072020808984 no 671 0.18960334361118 1074 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_207 4185-0010 4.486 µM 0.878740931139591 0.193243298393359 no 672 0.18977088007948 1015 3761753
SGTC_1490 4089-0339 670 nM 0.878440769728114 0.193326519743488 no 673 0.189852283793026 911 742542
SGTC_2465 5809242 33.21 µM 0.878375718187464 0.193344558512701 no 674 0.189869928587937 952 2731748
SGTC_2703 st077852 53.4 µM 0.877446142895159 0.193602441599254 no 675 0.190122179800057 896 6281836
SGTC_947 3447-0010 211 µM 0.875441261312459 0.194159350164422 no 676 0.190666928683136 935 748350
SGTC_3327 9140648 26.9345 µM 0.872586229449958 0.194954092443771 no 677 0.191444324513878 949 8029710
SGTC_779 1360-0071 233 µM 0.870966009708919 0.195405984137334 no 678 0.191886356258917 1004 7566
SGTC_2098 5376439 882.5 nM 0.869994623377425 0.195677216050843 no 679 0.192151671239308 991 2844116
SGTC_2433 5607874 27.82 µM 0.86779382652581 0.196292570685918 no 680 0.19275360512167 952 2252428
SGTC_2748 diazoxide 86.69 µM 0.865274090799808 0.196998541013966 no 681 0.193444183968606 879 3019 A potassium channel activatior.
SGTC_1767 st044992 70.3 µM 0.863714347962932 0.197436313146189 no 682 0.193872414875423 971 9600693
SGTC_2729 fluphenazine 10.66 µM 0.862040647694886 0.197906723369947 no 683 0.194332575141133 982 3372 An atypical antipsychotic.
SGTC_2152 5568786 200 µM 0.861979898568432 0.197923810243589 no 684 0.194349289753251 938 5399883
SGTC_1969 st069479 40.1 µM 0.859831791954063 0.198528579723642 no 685 0.194940885811811 917 3895485
SGTC_3156 9099931 49.47 µM 0.85537708283581 0.199786288560099 no 686 0.196171213230517 1014 18111053
SGTC_2937 9044753 11.33 µM 0.854837467664153 0.199938964201144 no 687 0.196320566356924 1015 6465530 YGL099W LSG1
SGTC_2058 5236698 133 µM 0.853746458592138 0.200247862331729 no 688 0.196622743186791 938 766665
SGTC_202 3594-0513 34.79 µM 0.853125405960805 0.200423829393492 no 689 0.196794881938583 968 708429
SGTC_42 0133-0086 60.653 µM 0.853031131392966 0.200450548964711 no 690 0.196821020238266 932 162923 Model of phenazepam hydroxylation.
SGTC_2603 homopterocarpin 100 µM 0.851852651105545 0.200784737766506 no 691 0.19714793970367 961 101795 A weak amylase inhibitor.
SGTC_2083 5306046 65.942 µM 0.850271094258436 0.201233754567826 no 692 0.197587191699006 961 539837
SGTC_2051 5263410 176 µM 0.849951497166814 0.201324563839965 no 693 0.197676026455187 1013 227584
SGTC_1707 st032323 6.317 µM 0.849688085846598 0.201399427134041 no 694 0.197749262036959 956 3132057 YMR211W DML1
SGTC_1146 3579-1023 7 µM 0.84958249350662 0.201429441881456 no 695 0.197778624210582 1025 X1146
SGTC_3041 9091929 49.47 µM 0.849124058585285 0.201559783630687 no 696 0.197906132236885 1043 25236887
SGTC_596 1155-0152 116 µM 0.848691346714959 0.201682858174523 no 697 0.198026531257789 992 280313
SGTC_2189 6047310 154.431 µM 0.8474085719925 0.202047977185515 no 698 0.198383714110603 937 711535
SGTC_505 gw-5074 63.9 µM 0.845939784437583 0.202466526864243 no 699 0.198793168455084 987 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_3335 9143315 29.6265 µM 0.843912584965604 0.203045053845604 no 700 0.199359127568666 953 4899691
SGTC_2646 retinol 96.75 µM 0.843057312273498 0.203289429363866 no 701 0.199598195653454 972 445354 A vitamin A analog and teratogen.
SGTC_2669 eugenol 100 µM 0.842458475679887 0.203460638285096 no 702 0.199765686682314 959 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_1385 3091-4834 14.1 µM 0.842139559493424 0.20355185233422 no 703 0.199854920133087 934 4072814
SGTC_639 0833-0042 114 µM 0.837463880197879 0.204891953479503 no 704 0.201165935845849 994 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_1327 1436-0082 2.18 µM 0.836503088743451 0.205167975211735 no 705 0.201435969920957 974 15992205
SGTC_128 0906-2981 13.371 µM 0.836499897452886 0.205168892392189 no 706 0.201436867207065 913 6740226
SGTC_1623 st003709 20.3 µM 0.835909223504266 0.205338694696366 no 707 0.201602986572648 985 16192618
SGTC_424 splitomicin 100 mM 0.835901816717564 0.205340824470982 no 708 0.201605070155943 906 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2666 tannic acid 100 µM 0.835211920238669 0.205539257358659 no 709 0.201799199639284 1020 16134267 A thiamine antagonist.
SGTC_6 0844-0013 19.835 µM 0.834224596889222 0.205823436226129 no 710 0.20207721650031 1165 1584900
SGTC_2827 7993847 71.43 µM 0.834100969168326 0.205859036106335 no 711 0.202112044529229 915 2985692
SGTC_746 1095-0025 46.6 µM 0.831997639250624 0.206465271290672 no 712 0.202705138516927 1013 6749286
SGTC_2507 purpurin 79.67 µM 0.829725068188818 0.207121473572038 no 713 0.203347122401516 1025 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_734 2023-0417 80 µM 0.82839118331268 0.207507205212351 no 714 0.203724499020707 978 3935732
SGTC_1909 st060837 51.5 µM 0.827495977176586 0.207766318045125 no 715 0.203978000632627 931 678937
SGTC_2161 5662504 8.5105 µM 0.826444425575188 0.208070928235375 no 716 0.204276015585678 952 2859334
SGTC_2127 5253358 187.912 µM 0.824706023192668 0.208575080921881 no 717 0.204769255649605 916 20612
SGTC_1017 4239-0030 168 µM 0.82374722693424 0.208853448528484 no 718 0.205041599463559 976 1149593
SGTC_1302 1159-0335 255 µM 0.82355580745581 0.208909049604139 no 719 0.205095997485806 984 649284
SGTC_1342 1486-1464 234 µM 0.823467473930253 0.208934710534176 no 720 0.205121103199789 1014 3253938
SGTC_297 0986-0032 24 µM 0.82256919122721 0.209195767504074 no 721 0.205376512332368 989 2847425
SGTC_1027 k015-0025 8.67 µM 0.822359188800283 0.209256825635885 no 722 0.205436249648246 1015 3598955
SGTC_1614 st002383 48.6 µM 0.82054493030848 0.209784757278659 no 723 0.205952763340492 1023 1947235
SGTC_3131 9127911 49.47 µM 0.819643069407695 0.2100474811654 no 724 0.206209806669894 959 45595681
SGTC_612 0302-0167 22.4 µM 0.818589578119457 0.210354621635924 no 725 0.206510307536998 1068 235821
SGTC_2384 9036245 200 µM 0.816994917767094 0.210820038729671 no 726 0.206965666209041 1030 6462766
SGTC_3353 9151644 39.2805 µM 0.816348897396418 0.211008757796233 no 727 0.207150307688421 992 4909158
SGTC_2134 5324836 1.464 µM 0.815149789364061 0.211359310297182 no 728 0.207493287368671 951 699272
SGTC_1002 4049-0206 172 µM 0.814906670302701 0.211430426359427 no 729 0.207562867373982 1070 4662749
SGTC_349 k015-0014 24 µM 0.814848460819217 0.211447455607064 no 730 0.207579528813376 950 2196908
SGTC_203 k066-0004 30.888 µM 0.813093431745818 0.211961268346621 no 731 0.208082246007968 1138 6795412
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM 0.812651172377258 0.212090861935584 no 732 0.20820904172841 1062 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_2798 7813637 45.45 µM 0.812463536870296 0.212145858052918 no 733 0.208262850582468 993 956368
SGTC_634 1611-4317 11.2 µM 0.810442467863019 0.212738763355569 no 734 0.20884295915676 1072 2843522
SGTC_346 4513-0042 7.16 µM 0.810260070275191 0.212792319470725 no 735 0.208895359635608 1010 2827372
SGTC_2265 7929201 200 µM 0.809344349813684 0.213061314920334 no 736 0.209158551368808 1074 1265108
SGTC_1503 4585-0012 61.3 µM 0.80763729275401 0.213563296962949 no 737 0.209649705931457 1024 2922052
SGTC_3320 9137005 35.139 µM 0.807506062106876 0.213601915524005 no 738 0.209687491675873 956 4908713
SGTC_2651 TUB2.036 5 µM 0.806684370240821 0.213843815526143 no 739 0.2099241755956 1166 15992207 YFL037W TUB2
SGTC_750 4073-0104 132 µM 0.805580851012261 0.21416893426091 no 740 0.210242285268509 876 22330957
SGTC_2914 7968218 45.32 µM 0.805441840891907 0.214209909797061 no 741 0.210282377554282 962 2977111
SGTC_2043 5101342 149 µM 0.805082942933654 0.214315722003541 no 742 0.210385909043929 1003 678451
SGTC_1860 st056228 74.6 µM 0.804755574666657 0.214412264965889 no 743 0.210480371238273 1023 688679
SGTC_3244 9134489 49.47 µM 0.80423017802398 0.214567260595483 no 744 0.210632026594913 1029 16584271
SGTC_2404 5161160 200 µM 0.802563115886388 0.215059486395547 no 745 0.211113647112825 1042 2831543
SGTC_340 k038-0059 454 µM 0.802410868398008 0.215104472463008 no 746 0.211157664124578 1041 23733424
SGTC_3294 9122953 26.2835 µM 0.802257016716415 0.215149938086593 no 747 0.211202150395392 1100 16459826
SGTC_2311 7694451 200 µM 0.801990859606518 0.215228604925272 no 748 0.211279122788984 990 2163142
SGTC_1256 0570-0116 285 µM 0.801700952969927 0.21531431029476 no 749 0.211362982220704 1012 410638
SGTC_1839 st053978 48 µM 0.801213900433259 0.21545834266516 no 750 0.211503912663519 1057 3788398
SGTC_2231 micatex 6.853 µM 0.801075448462808 0.21549929622082 no 751 0.211543984291552 1049 20737 An antifungal of unknown mechanism.
SGTC_8 0354-0001 70 µM 0.799854533451219 0.21586063355092 no 752 0.211897541465744 1102 4993152
SGTC_1208 2323-2347 50.3 µM 0.799773398618475 0.21588465834037 no 753 0.211921049039321 1050 5412760
SGTC_3317 9138495 8.753 µM 0.799692881545362 0.215908501737108 no 754 0.211944379134584 1074 17020139
SGTC_3256 9138902 49.47 µM 0.799071222396672 0.216092644066644 no 755 0.212124557553931 1071 17228773
SGTC_3276 9139060 49.47 µM 0.798833841932004 0.216162982782362 no 756 0.212193382280745 1056 4870619
SGTC_1236 0330-0013 258 µM 0.798788282482647 0.21617648411709 no 757 0.212206593018466 999 4617066
SGTC_2088 5278280 127.392 µM 0.798298986178009 0.216321515623213 no 758 0.212348503115999 1065 791502
SGTC_3070 9117005 49.47 µM 0.798231636945485 0.216341482906554 no 759 0.212368040684862 1025 8779016
SGTC_164 4100-3994 89.624 µM 0.797501382316617 0.2165580527621 no 760 0.212579950176042 1087 4615967
SGTC_1926 methyl fluorone black 53.6 µM 0.796475546636087 0.216862494132579 no 761 0.212877841579457 939 72721 Reacts with homocysteine.
SGTC_1719 st032227 49.2 µM 0.796345885241471 0.216900991870496 no 762 0.212915511158544 1081 3125804
SGTC_1299 1079-1439 3.74 µM 0.795479956852573 0.217158195761533 no 763 0.21316718273758 1045 323161
SGTC_306 1672-3436 11.6 µM 0.795443500856883 0.217169028031054 no 764 0.213177782035039 1071 6797378
SGTC_476 mead acid 10 µM 0.794902968632886 0.217329674467758 no 765 0.213334973640762 1053 5312531 An omega 9 fatty acid.
SGTC_682 0kpi-0099 17 µM 0.793919657356145 0.21762209095083 no 766 0.213621102571155 1061 1714895 YML126C ERG13
SGTC_3101 9120531 49.47 µM 0.793638951086966 0.217705608842407 no 767 0.213702824918263 1046 24824904
SGTC_1459 k035-0031 35.7 µM 0.790307224202618 0.218698301228132 no 768 0.214674184422544 924 3877128 YMR208W ERG12
SGTC_2686 alizarin 95.37 µM 0.788660023680999 0.219190047624385 no 769 0.215155369369041 1028 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_905 2-aminofluorene 215 µM 0.786921843893664 0.219709643086071 no 770 0.215663809710897 1128 1539 An established DNA mutagen. YPR165W RHO1
SGTC_2068 5226020 147 µM 0.786383589744375 0.219870687114617 no 771 0.215821397242299 1130 1810509
SGTC_555 4296-0685 37 µM 0.785452324898399 0.220149478712363 no 772 0.216094206168664 1073 2908540 YHR072W ERG7
SGTC_3326 9140064 16.379 µM 0.783131409456274 0.220845169874783 no 773 0.216774974110985 1084 1868434
SGTC_2455 5377712 9.75 µM 0.782565102236689 0.221015110514633 no 774 0.21694127063557 994 2243908
SGTC_1733 st037357 54.9 µM 0.779832856654052 0.221836068925205 no 775 0.21774463191962 1091 1272339 YGL099W LSG1
SGTC_2301 7769476 200 µM 0.779641979265788 0.221893486912326 no 776 0.217800819599933 1045 977820
SGTC_369 0957-0393 4.5 µM 0.778726114689126 0.222169106936631 no 777 0.218070534661766 1060 6997992
SGTC_3336 9143619 71.43 µM 0.778390613192788 0.222270121536793 no 778 0.218169385429708 1096 45595730
SGTC_2840 9008771 71.43 µM 0.776062720770652 0.222971737261485 no 779 0.218855976811423 1044 2992978
SGTC_2484 5809818 12.04 µM 0.775197896585135 0.223232712186906 no 780 0.219111365460536 1032 2870548
SGTC_231 b-estradiol 524 µM 0.774869816626705 0.223331761184099 no 781 0.219208294589279 1028 450 A steroid.
SGTC_1091 telmisartan 47.6 µM 0.774285637912812 0.223508189588473 no 782 0.219380947466072 1136 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_2171 5739187 198.077 µM 0.773603298456653 0.223714363964282 no 783 0.219582710459648 1051 2262761
SGTC_2312 7706453 155.7 µM 0.773563932401224 0.223726262033879 no 784 0.219594353976938 1052 976098
SGTC_2955 9076254 12.21 µM 0.773223928188713 0.223829040508398 no 785 0.219694933670741 1047 16459619
SGTC_3350 9150499 3.57 µM 0.772550703062007 0.224032626117266 no 786 0.219894164449242 1107 4910996 YPR165W RHO1
SGTC_2784 7567673 72.73 µM 0.772509459464164 0.22404510174276 no 787 0.219906373237 1108 3471247
SGTC_3168 9103419 49.47 µM 0.772129354907097 0.224160096761134 no 788 0.220018908789738 1030 16649256
SGTC_2070 5230947 200 µM 0.769045596608522 0.225094280469472 no 789 0.220933121378321 1170 2835538
SGTC_3323 9138564 53.9225 µM 0.768505333938085 0.225258172669068 no 790 0.221093511490994 1135 43912313 YNL103W MET4
SGTC_2783 7738165 71.43 µM 0.76819521069093 0.225352281099641 no 791 0.221185609210751 1017 17201110
SGTC_2878 9043973 25.97 µM 0.766892956412853 0.225747699514571 no 792 0.221572580916821 1075 6465167
SGTC_2415 st077333 57.7 µM 0.76531410735826 0.22622762952092 no 793 0.22204226275584 1138 2766255
SGTC_1251 0490-5699 265 µM 0.764386600428697 0.226509836649821 no 794 0.22231844575479 1150 3883818
SGTC_3217 9129673 49.47 µM 0.763655670104607 0.226732372525176 no 795 0.222536232303613 1065 17248312
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.76356155509995 0.226761035333714 no 796 0.222564283461157 998 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_1406 3909-7906 11.9 µM 0.762872438811948 0.226970968593127 no 797 0.222769737304278 1107 X1406
SGTC_3034 9090421 49.47 µM 0.762464133538143 0.227095406920978 no 798 0.222891520833889 1047 17173761
SGTC_2734 clemastine 41.6 µM 0.761652888894627 0.227342762312144 no 799 0.223133599934138 1034 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_946 3434-1334 87.4 µM 0.761568915320225 0.227368375235925 no 800 0.223158666578249 1058 4047976
SGTC_1652 st011932 78 µM 0.757468240045455 0.22862110559293 no 801 0.224384693255324 1073 1551076
SGTC_412 gemfibrozil 100 µM 0.756898432514466 0.228795484405425 no 802 0.224555357270048 1085 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_2591 skatole 100 µM 0.755607891758422 0.229190705901176 no 803 0.224942161467292 1099 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_283 0987-0079 11.7 µM 0.754778595600442 0.22944487552546 no 804 0.225190919427269 1139 411556
SGTC_1769 st044406 64.4 µM 0.754731992026679 0.229459163665215 no 805 0.225204903386708 1099 670903
SGTC_2224 6650123 117.647 µM 0.754700394320388 0.229468851455779 no 806 0.225214384936024 1075 2908370
SGTC_1305 1181-0477 144 µM 0.754515291388586 0.229525608231135 no 807 0.225269933464541 1091 6252086
SGTC_677 0929-0063 136 µM 0.752641030621484 0.230100742124286 no 808 0.225832827268073 1055 1539583
SGTC_398 bronopol 33.3 µM 0.752074711850948 0.230274680661634 no 809 0.226003065257573 1071 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_1172 0370-0043 85 µM 0.750868515905954 0.230645395367813 no 810 0.226365894924268 1124 376585
SGTC_1732 st034308 51.822 µM 0.750022737768326 0.230905537289838 no 811 0.226620505242086 1028 830119
SGTC_1886 st057356 49.9 µM 0.748603499882164 0.231342430129616 no 812 0.227048111007221 1085 24207747
SGTC_57 miconazole 162.5 nM 0.748400017327256 0.2314051071997 no 813 0.227109456046017 1074 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_1897 st060201 15 µM 0.746930088795957 0.231858158450467 no 814 0.227552881176226 1087 611878
SGTC_940 3232-1287 54.8 µM 0.746901923553559 0.231866844168803 no 815 0.227561382385197 1106 1585493 YIL048W NEO1
SGTC_727 3032-0951 202 µM 0.745570760872466 0.232277560463457 no 816 0.22796337556809 1100 3652836
SGTC_2167 5876490 200 µM 0.743303907304285 0.232977905044042 no 817 0.2286488532594 1126 686534
SGTC_2830 7992007 71.43 µM 0.743115727855881 0.23303609577134 no 818 0.228705809147203 1045 1952075
SGTC_1648 st011736 69.8 µM 0.742158913134624 0.23333209638422 no 819 0.228995529490368 1127 2855514
SGTC_1089 terbinafine 2.25 µM 0.741884257253408 0.23341710256792 no 820 0.229078732408589 1111 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_3251 9135047 49.47 µM 0.741217562506145 0.233623516499184 no 821 0.229280768201306 1102 17682963
SGTC_922 1866-0035 480 µM 0.739548121614699 0.234140832267972 no 822 0.229787115143949 1148 3156169
SGTC_1947 st076332 61.6 µM 0.738731618314965 0.234394075931124 no 823 0.230034991122409 1126 24208416
SGTC_2383 9036125 200 µM 0.73820378527436 0.234557867315939 no 824 0.230195311506063 1088 79580
SGTC_1637 st007924 17.4 µM 0.736808101023605 0.234991265673046 no 825 0.230619528031473 1131 683336
SGTC_853 0419-0306 21 µM 0.736024602425263 0.235234757315006 no 826 0.230857862783453 1090 762713
SGTC_1244 0416-0015 52.5 µM 0.735797115032127 0.235305480757689 no 827 0.230927088601892 1132 96201
SGTC_1743 st037606 46.3785 µM 0.732772231851963 0.236247000101454 no 828 0.231848680088127 1137 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_554 4483-2211 187 µM 0.732241931321835 0.236412273903208 no 829 0.232010457604064 1098 747107
SGTC_2445 5742597 35.57 µM 0.730846047718511 0.236847619981645 no 830 0.232436596792317 1092 1774255
SGTC_2337 9009472 200 µM 0.730170324405643 0.23705852178344 no 831 0.23264303973028 1140 5742383
SGTC_277 nystatin 15.5 µM 0.729489121042807 0.237271238396325 no 832 0.232851260025544 1160 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2662 daunorubicin 22.37 µM 0.729325035139286 0.237322492499033 no 833 0.232901430877319 1122 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1266 0828-0227 32.9 µM 0.729184430988087 0.237366416645382 no 834 0.232944426733252 1101 3913820
SGTC_1147 3809-1045 12.3 µM 0.726976486744898 0.238056754251341 no 835 0.233620179952396 1114 325925
SGTC_3114 9122766 49.47 µM 0.725681140948346 0.238462269705145 no 836 0.234017132848369 1090 17176985
SGTC_174 3553-0389 74.3 µM 0.72539663856996 0.238551385439489 no 837 0.234104367334714 1120 738071
SGTC_2689 tacrolimus 100 µM 0.724566100662474 0.238811642160689 no 838 0.234359130928561 1146 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_783 0848-0141 92.7 µM 0.72357877061151 0.239121233102715 no 839 0.234662189285197 1132 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2508 celastrol 40.54 µM 0.721318386594545 0.239830832881558 no 840 0.235356823493138 1119 122724 Celastrol is a natural product and antioxidant.
SGTC_2253 7938677 135.83 µM 0.720897288529506 0.239963154538544 no 841 0.235486355621612 1157 2301972
SGTC_3235 9132602 49.47 µM 0.720878514057804 0.239969054968257 no 842 0.235492131670367 1191 4912240
SGTC_1283 0922-0125 16.4 µM 0.720582611774569 0.240062061409859 no 843 0.235583177633511 1166 3360884
SGTC_2920 7982904 15.77 µM 0.719000730682713 0.240559603109516 no 844 0.236070234738003 1112 6456808
SGTC_1953 st076800 12.1 µM 0.71770138623874 0.240968699486615 no 845 0.23647071418769 1120 297591
SGTC_2177 5811945 192 µM 0.716841358157695 0.241239685826079 no 846 0.236735994588339 1175 5343475
SGTC_2037 5169046 200 µM 0.716674466828645 0.241292290814165 no 847 0.236787492094891 1147 5718022
SGTC_2332 7982454 138.89 µM 0.71497346077987 0.241828811865518 no 848 0.237312721212999 1147 2981748
SGTC_1604 st002052 72.4 µM 0.714030938977401 0.242126374882411 no 849 0.237604024166663 1198 6254834 YHR062C RPP1
SGTC_1781 st038725 66.3 µM 0.713893000925368 0.242169939872043 no 850 0.237646672803218 1187 4270275 YIL048W NEO1
SGTC_2140 5586273 200 µM 0.713331690573702 0.242347262401648 no 851 0.237820265917026 1164 854421
SGTC_1128 3448-9350 235 µM 0.712907580464198 0.242481288900994 no 852 0.237951474037647 1122 619386
SGTC_2957 9076800 11.52 µM 0.70860429900068 0.243843471718097 no 853 0.239285033886647 1123 16459615
SGTC_2424 5537928 59.2 µM 0.708380745925103 0.243914349025424 no 854 0.239354422966134 1231 5382802
SGTC_1356 1502-0781 85.8 µM 0.706912731735276 0.244380057695357 no 855 0.239810355726681 1141 567702
SGTC_3133 9127736 49.47 µM 0.706301555146178 0.244574086810841 no 856 0.240000313265135 1188 27243420
SGTC_1530 rhein 70.4 µM 0.705990889367825 0.244672745106672 no 857 0.240096901591401 1219 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2924 9010168 62.78 µM 0.705873512414176 0.244710026145188 no 858 0.240133400483705 1199 2993929
SGTC_2418 pentamidine 31.67 µM 0.705393239215847 0.244862601434404 no 859 0.24028277509741 1176 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1104 tacrolimus 29.8 µM 0.705164857177347 0.244935172796381 no 860 0.240353824257419 1227 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_2294 7971431 200 µM 0.70219090045334 0.245881241918376 no 861 0.241280059809002 1109 5741572
SGTC_2053 5265679 138 µM 0.702133936217816 0.245899382389187 no 862 0.241297820169929 1178 764595
SGTC_2849 9019321 12.99 µM 0.701542794721779 0.246087675972473 no 863 0.24148216873124 1151 16489627
SGTC_348 k064-0012 10.7 µM 0.700469541719735 0.246429731894885 no 864 0.241817060071809 1145 5066323
SGTC_3340 9146634 11.102 µM 0.698228744999873 0.247144715624763 no 865 0.242517076292972 1187 4907387
SGTC_3275 9138069 49.47 µM 0.697522579006565 0.247370265717808 no 866 0.242737907041465 1186 17617007
SGTC_2076 5212012 200 µM 0.697370797440021 0.247418759256954 no 867 0.242785386062446 1103 604802
SGTC_3022 9087993 49.47 µM 0.697144362430532 0.247491113683429 no 868 0.242856226881101 1201 17173644
SGTC_1617 st002906 78 µM 0.696708283278754 0.247630489075558 no 869 0.242992686956049 1192 5150859
SGTC_1871 st057448 67.3 µM 0.695254025687048 0.24809558765686 no 870 0.243448060173474 1277 691747
SGTC_2701 st077767 14.721 µM 0.694604770711658 0.248303381814727 no 871 0.243651510837296 1208 5721188
SGTC_2987 9018338 71.43 µM 0.693655748842825 0.248607283273628 no 872 0.243949061611795 1241 5055682
SGTC_3325 9138760 55.175 µM 0.691500214967427 0.249298276651493 no 873 0.244625622836326 1192 43844959
SGTC_268 camptothecin 39.6153 µM 0.687808502521028 0.250484086369604 no 874 0.245786690556011 1213 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_551 k048-0028 34.9 µM 0.687733127728243 0.250508328497275 no 875 0.245810427200275 1212 6836383
SGTC_2992 9074591 71.4286 µM 0.687697406452873 0.250519817649179 no 876 0.245821676791388 1208 17741321
SGTC_3030 9087619 49.47 µM 0.687625624658474 0.250542905909266 no 877 0.245844283646203 1185 25236973
SGTC_1324 1418-0026 34.4 µM 0.685818447804424 0.251124546716402 no 878 0.246413800840761 1224 1372513
SGTC_977 1348-1378 135 µM 0.685796546084504 0.251131600174298 no 879 0.246420707324718 1213 X977
SGTC_2762 leflunomide 42.06 µM 0.684962327205203 0.251400338700766 no 880 0.24668384694804 1204 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1499 4480-0877 67.3 µM 0.683072789361677 0.25200960341268 no 881 0.247280424311348 1151 2861909
SGTC_3283 9109332 35.8195 µM 0.681734714170304 0.252441524630232 no 882 0.247703356316867 1119 17027281
SGTC_165 k038-0023 64.381 µM 0.680483029360603 0.25284591252843 no 883 0.248099331901635 1224 46368543
SGTC_1482 3346-2049 8.48 µM 0.679470632560943 0.253173241762527 no 884 0.248419854590529 1207 3826804
SGTC_765 1319-0117 244 µM 0.679379910696844 0.253202584930662 no 885 0.248448587711677 1209 3487746 YGL099W LSG1
SGTC_463 ikarugamyin 104 µM 0.677587160233838 0.253782800555608 no 886 0.249016744679082 1260 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_1357 1503-1303 39.5 µM 0.676410347956241 0.254164049710773 no 887 0.249390074542545 1234 292895
SGTC_1659 st012954 42.1 µM 0.674704848228074 0.254717109150937 no 888 0.249931651843273 1213 24207262
SGTC_925 2064-1272 59.6 µM 0.67347625539123 0.2551159073526 no 889 0.250322174955916 1208 6815817
SGTC_1372 2752-0194 270 µM 0.672186658282278 0.255534858412259 no 890 0.250732436748385 1209 823334
SGTC_1527 coumarin 137 µM 0.670897118651968 0.255954149902727 no 891 0.25114303602085 1265 323 A hepatotoxic, DNA x-linker.
SGTC_275 trichlorophene 5.69 µM 0.669525821784051 0.256400418125337 no 892 0.251580057308126 1272 62616
SGTC_3104 9120930 49.47 µM 0.66949583001293 0.256410183031267 no 893 0.251589619931891 1240 17014836
SGTC_1206 3978-0017 132 µM 0.669263787921994 0.256485739276354 no 894 0.251663611088656 1291 3873677
SGTC_3019 9081971 49.47 µM 0.668341478030438 0.256786171290114 no 895 0.251957821219067 1280 16451803
SGTC_1510 1123-0200 71.5 µM 0.668070028847622 0.256874627666932 no 896 0.252044446088526 1308 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_962 1254-0300 21.5 µM 0.668043894124876 0.256883144951803 no 897 0.252052787031017 1204 7340576
SGTC_2893 9048488 25.97 µM 0.667331625531478 0.257115329275203 no 898 0.252280164855969 1202 6467338
SGTC_93 0109-0045 59.227 µM 0.666886981796482 0.257260328929519 no 899 0.25242216348697 1304 88733
SGTC_1241 0364-0022 50.8 µM 0.666161450784466 0.257497017998928 no 900 0.252653954927999 1248 4563895
SGTC_2918 7977171 22.06 µM 0.666114306747831 0.257512401651687 no 901 0.252669020304358 1192 2236483
SGTC_2909 7941780 10.49 µM 0.665933742764913 0.257571326215058 no 902 0.252726725813974 1240 1243215
SGTC_583 1488-1091 88.9 µM 0.664850926242613 0.25792483529251 no 903 0.253072923090744 1328 4303273
SGTC_2944 9067346 25.62 µM 0.661693003968711 0.258957243599034 no 904 0.25408399461877 1211 6473075
SGTC_662 k832-1615 104 µM 0.661482345509194 0.259026189393583 no 905 0.254151516417292 1247 5878478
SGTC_2029 5175081 200 µM 0.661477655548692 0.259027724465134 no 906 0.254153019785002 1250 1380876
SGTC_3118 9124250 49.47 µM 0.660786125479893 0.259254120736233 no 907 0.254374740910522 1183 1504786
SGTC_1034 k072-0165 12.7 µM 0.660529990242521 0.259338001405547 no 908 0.254456889732667 1253 5835461
SGTC_2851 9015922 71.43 µM 0.660048027212081 0.259495875493366 no 909 0.254611504721623 1254 2996893
SGTC_1463 k081-0032 34.1 µM 0.659075142782023 0.259814709264576 no 910 0.254923758422281 1119 977755
SGTC_1203 3992-3522 103 µM 0.658850253438824 0.259888438770738 no 911 0.254995966651686 1427 5322312
SGTC_315 k915-0449 187 µM 0.658400085363329 0.260036057862655 no 912 0.25514054028043 1288 20970215 YNL149C PGA2
SGTC_1709 st033179 39.1045 µM 0.657693367932417 0.260267891790229 no 913 0.255367592406272 1231 573381
SGTC_149 3970-0822 46.1 µM 0.65672103663613 0.260587032548689 no 914 0.255680152695857 1313 3114250 YBL034C STU1
SGTC_3142 9086498 49.47 µM 0.656057413683313 0.260804963972695 no 915 0.255893591934352 1199 25236367
SGTC_1562 morin hydrate 59.1 µM 0.650722951560227 0.262560182318689 no 916 0.257612672307702 1287 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_857 0438-0306 1.35 µM 0.646870410990074 0.263831547611092 no 917 0.258857908669704 1294 4686136
SGTC_1194 1488-0194 225 µM 0.646795275107041 0.263856374146611 no 918 0.258882225369562 1260 1391452
SGTC_1806 st050005 60.3 µM 0.645215021416559 0.2643788002612 no 919 0.259393926516433 1240 5194765
SGTC_3020 9089140 49.47 µM 0.645010032097275 0.264446607544541 no 920 0.259460342268377 1276 17217859
SGTC_3249 9135183 49.47 µM 0.642670916796116 0.265220976780498 no 921 0.260218828097226 1300 4902779
SGTC_2006 4011487 200 µM 0.642623693839898 0.265236621891863 no 922 0.260234152458805 1321 45595294
SGTC_2440 5628896 157.78 µM 0.642521684529149 0.265270419491122 no 923 0.26026725717406 1307 5522048
SGTC_2270 7924575 90.91 µM 0.640243209147344 0.266025890513501 no 924 0.26100724773009 1283 1262135
SGTC_1354 1498-1681 81 µM 0.639847577830642 0.266157180414858 no 925 0.261135848804861 1318 5754243
SGTC_2754 granisetron 64.02 µM 0.639697741813539 0.266206911927986 no 926 0.261184561925669 1297 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_3212 9128307 49.47 µM 0.638477443591685 0.266612111644722 no 927 0.261581466349829 1229 27243542
SGTC_2473 5854593 8.94 µM 0.634064807998132 0.268079924128804 no 928 0.263019264185676 1271 2872951
SGTC_2001 4023502 57.655 µM 0.631067096659489 0.269079393453856 no 929 0.263998326987626 1318 108941 YCR052W RSC6
SGTC_2805 7950783 58.44 µM 0.629582180701839 0.269575172101111 no 930 0.264483992573342 1311 1178958 YDL195W SEC31
SGTC_2875 9039966 71.43 µM 0.628905743066482 0.269801170425856 no 931 0.264705382989005 1380 6463691
SGTC_2261 9010538 184.68 µM 0.627720127617667 0.270197514170218 no 932 0.265093648784033 1234 6457250
SGTC_862 0452-0056 10.2 µM 0.627106063520771 0.2704029063123 no 933 0.265294856377029 1248 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_3155 9099265 49.47 µM 0.625252768747412 0.271023269059589 no 934 0.265902586764417 1279 25236499
SGTC_1885 st057546 99.9 µM 0.624860521808993 0.27115465883826 no 935 0.266031302341893 1361 702008
SGTC_1881 5652484 16 µM 0.624788066373494 0.271178932492665 no 936 0.266055081998661 1274 2255129
SGTC_2382 9035899 200 µM 0.624123140816988 0.27140174307788 no 937 0.266273358834081 1310 6462679
SGTC_794 k038-0031 316 µM 0.624049646108279 0.271426376092018 no 938 0.266297490694263 1318 6624242
SGTC_2935 9038016 29.96 µM 0.623178888780775 0.271718310117666 no 939 0.266583486571249 1280 6463195
SGTC_1546 5-methoxyflavanone 78.7 µM 0.622301111562007 0.272012755763909 no 940 0.266871945212419 1352 147795
SGTC_502 l-744,832 89.3 µM 0.622188927707194 0.272050398666993 no 941 0.266908822878792 1273 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_53 0973-0023 39.979 µM 0.621329476585048 0.272338870415751 no 942 0.267191431549197 1294 674768
SGTC_200 k038-0079 37.545 µM 0.62119329112037 0.272384594531857 no 943 0.267236226538193 1309 3436683
SGTC_2323 6148992 148.28 µM 0.620922917712989 0.272475383397154 no 944 0.267325170708612 1270 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_757 1066-0008 322 µM 0.619103800154521 0.273086616482105 no 945 0.267923990020971 1351 6842497
SGTC_521 r062-0005 13.8 µM 0.616722365704934 0.273887816802982 no 946 0.268708933196036 1266 2832033
SGTC_1809 st050081 57.6 µM 0.616312973157465 0.274025668171558 no 947 0.268843989115864 1366 5036894
SGTC_1377 2944-0135 198 µM 0.616079101860983 0.274104433105182 no 948 0.268921157021159 1392 1894137
SGTC_2767 sibutramine 71.45 µM 0.615753191469576 0.274214214308097 no 949 0.269028712584764 1394 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_97 0535-0701 19.132 µM 0.615194663288484 0.274402402071416 no 950 0.269213085875571 1273 2832013 YGL099W LSG1
SGTC_367 0335-0881 7.1 µM 0.614227321272336 0.274728484311763 no 951 0.269532560791803 1313 23828853
SGTC_1071 trifluoperazine 6.31 µM 0.613326716590111 0.275032241648174 no 952 0.269830165682944 1370 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1178 0988-0033 191 µM 0.611940035399555 0.275500266858301 no 953 0.270288716045905 1336 5392207
SGTC_2821 7996764 71.43 µM 0.611385442890311 0.275687559559604 no 954 0.27047221875522 1385 2987135
SGTC_2973 9094665 17.96 µM 0.608441676258559 0.276682752282086 no 955 0.271447288666753 1391 25237061 YIL048W NEO1
SGTC_547 1120-0019 610 nM 0.606269973277582 0.277418061781696 no 956 0.272167747095827 1341 3676939
SGTC_617 3770-0098 35 µM 0.604063444763099 0.278166139821884 no 957 0.272900730981042 1343 5962639
SGTC_3201 9113999 49.47 µM 0.603977366100332 0.278195342945601 no 958 0.272929345169737 1389 16649224
SGTC_1304 1165-0502 251 µM 0.603056961867966 0.278507693529424 no 959 0.273235398055801 1348 767425
SGTC_908 3448-7491 47.7 µM 0.601879067142471 0.278907675758728 no 960 0.273627319557427 1337 1203031
SGTC_2067 5224629 34.075 µM 0.601148839228121 0.279155782308917 no 961 0.273870428248458 1317 2835000
SGTC_1277 0873-0036 22 µM 0.601015630200064 0.279201053764066 no 962 0.273914787934009 1414 5965735
SGTC_3074 9116018 49.47 µM 0.599761785141657 0.279627351249983 no 963 0.274332502473948 1383 17027303
SGTC_3226 9131256 49.47 µM 0.599277642433558 0.279792040479639 no 964 0.274493877212918 1252 17178073
SGTC_881 0833-0569 170 µM 0.598022860546254 0.280219094387441 no 965 0.274912339764893 1300 5418700
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.596119730968076 0.280867409748189 no 966 0.27554762193342 1459 16725076
SGTC_2504 purpurogallin 52.29 µM 0.594583738620348 0.28139118528735 no 967 0.276060876262765 1323 5281571 An antioxidant.
SGTC_2953 9074162 66.49 µM 0.592449028713581 0.282119906228351 no 968 0.276774971640976 1370 16451992
SGTC_579 4491-1009 110 µM 0.592371189000682 0.282146495349362 no 969 0.276801027387703 1442 1271041
SGTC_2877 9040724 71.43 µM 0.592262551613335 0.282183606606665 no 970 0.276837394230373 1403 6463895
SGTC_1545 lovastatin 49.4 µM 0.589433308619307 0.283150921366248 no 971 0.27778531893445 1397 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_444 curcumin 90.4 µM 0.585082344232704 0.284641608172018 no 972 0.27924617497244 1348 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_1722 st034304 3.6505 µM 0.584694730032403 0.284774590487384 no 973 0.279376499105445 1362 4036148 YLR033W RSC58
SGTC_844 0330-0132 15.3 µM 0.582579188197252 0.285500910604793 no 974 0.280088309473771 1381 2828079
SGTC_1525 8-methoxypsoralen 92.5 µM 0.581940030497289 0.285720523283512 no 975 0.280303537821061 1431 4114 Related to psoralen; DNA damaging agent.
SGTC_2965 9082772 38.63 µM 0.579882844501518 0.286427911292283 no 976 0.280996812725002 1420 16459634
SGTC_16 erodoxin 22.806 µM 0.578908349906475 0.286763292777256 no 977 0.281325507894249 1390 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_2934 9036370 36.88 µM 0.57810117153845 0.287041231687765 no 978 0.281597908075469 1406 6462800
SGTC_1051 3253-3903 78 µM 0.577035497848875 0.287408374597884 no 979 0.281957737930626 1340 5509239
SGTC_447 ml7 120 µM 0.576930360245583 0.287444608344759 no 980 0.281993250148972 1433 4216 Selective myosin light chain kinase inhibitor.
SGTC_2344 7990960 76.95 µM 0.576440707792191 0.287613386537331 no 981 0.282158667919778 1382 140813
SGTC_360 0957-0399 1.01 µM 0.57448878579333 0.288286659211667 no 982 0.282818543518052 1429 6752301 YPR165W RHO1
SGTC_3105 9121040 49.47 µM 0.57420769115202 0.288383677833564 no 983 0.282913632673463 1258 41448907
SGTC_1161 k007-0610 110 µM 0.574035411708945 0.288443146958679 no 984 0.282971919232327 1424 5843850
SGTC_2263 7948595 193.29 µM 0.573135097079545 0.28875402047675 no 985 0.283276612537096 1380 2971371
SGTC_1321 1326-2144 215 µM 0.573132511340076 0.288754913545018 no 986 0.283277487854962 1395 3513030
SGTC_2474 5321570 43.32 µM 0.572305659744997 0.289040560006473 no 987 0.283557458036048 1439 2841384
SGTC_631 k072-0230 41.5 µM 0.572291348563475 0.289045505157155 no 988 0.283562304938514 1424 5773147
SGTC_1126 isoteolin 1.0172 µM 0.571750914871938 0.289232278190415 no 989 0.283745367749016 1341 133323
SGTC_698 k064-0052 127 µM 0.571747769500655 0.289233365391812 no 990 0.283746433356187 1439 5088751
SGTC_1326 1431-2094 10.8 µM 0.571553141996828 0.289300642361188 no 991 0.283812374121178 1355 616278
SGTC_2501 sodium tetradecyl sulfate 13.37 µM 0.570847347671089 0.289544676247418 no 992 0.284051562267347 1366 23665772 A membrane-active detergent.
SGTC_774 k060-0086 136 µM 0.570791210950734 0.289564090104804 no 993 0.284070590699544 1413 5911235
SGTC_751 0833-0568 350 µM 0.56967666735148 0.289949661077981 no 994 0.284448509111623 1407 6954252
SGTC_1813 st051246 8.6015 µM 0.56914677240269 0.290133060074044 no 995 0.284628269606811 1369 5291959
SGTC_2230 bromochlorosalicylanilide 954.5 nM 0.568996841308939 0.290184961756539 no 996 0.284679141771895 1370 77254
SGTC_2892 9047358 58.44 µM 0.567329780098939 0.290762341601652 no 997 0.285245073933556 1365 6466771
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 0.566336935694748 0.291106464241499 no 998 0.285582378193058 1454 23847180
SGTC_1026 k007-1105 30.6 µM 0.566236418262532 0.291141314464812 no 999 0.285616538089371 1378 7066794
SGTC_3045 9092950 49.47 µM 0.56569796363675 0.291328034291415 no 1000 0.285799559887394 1498 44120432
SGTC_1995 st072814 61.1 µM 0.562694996701027 0.292370396163727 no 1001 0.286821295901371 1339 5769371
SGTC_3271 9137798 49.47 µM 0.562505805926733 0.292436124329652 no 1002 0.286885724509094 1379 6498326
SGTC_3300 9124615 50.48 µM 0.562199273852022 0.292542633483205 no 1003 0.286990128058476 1466 24824903
SGTC_1726 st035556 14.5795 µM 0.561863101376172 0.292659462358948 no 1004 0.287104647692546 1484 5919439
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.56157380377923 0.292760018314653 no 1005 0.287203216372135 1439 364106
SGTC_333 3486-0131 40.1 µM 0.559518956741427 0.293474716766374 no 1006 0.287903798719457 1474 6744690
SGTC_3062 9077494 49.47 µM 0.557877822621188 0.294046101115328 no 1007 0.288463908198456 1413 16459633
SGTC_2480 5767542 37.17 µM 0.557414355444368 0.294207556920961 no 1008 0.288622179782992 1434 2867358
SGTC_2154 5570129 200 µM 0.556956502783339 0.294367097028927 no 1009 0.288778574193825 1384 673366
SGTC_3260 9137109 49.47 µM 0.55612978930281 0.294655268912296 no 1010 0.289061065984045 1365 17478346
SGTC_302 1094-0063 18.9 µM 0.555383559884223 0.294915497725672 no 1011 0.289316167557883 1357 5440289
SGTC_1699 st031318 29.054 µM 0.555046743592285 0.295032988648828 no 1012 0.289431344224971 1456 5340658
SGTC_3081 9117243 49.47 µM 0.554087629455918 0.295367672487296 no 1013 0.289759437893334 1501 45595589
SGTC_1077 5-fluorocytosine 377 nM 0.55371078045842 0.295499222106718 no 1014 0.289888398098301 1415 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1756 st041558 35.5 µM 0.553430570236148 0.295597054737191 no 1015 0.289984305324795 1541 3955792
SGTC_2791 5663188 71.43 µM 0.551948783557361 0.29611465330789 no 1016 0.290491721902164 1475 54690634
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM 0.549200513361309 0.297075742849688 no 1017 0.291433926078554 1494 1377
SGTC_2156 5649887 115 µM 0.548527086653257 0.297311462351806 no 1018 0.291665017844208 1489 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_2217 6934799 96.0675 µM 0.548210636947869 0.297422258725308 no 1019 0.291773639585096 1425 675606
SGTC_580 1123-0028 41 µM 0.547125757030145 0.297802243385335 no 1020 0.292146168921591 1447 1677248 YPR107C YTH1
SGTC_815 1582-0027 36.9 µM 0.546529483632721 0.298011185396486 no 1021 0.292351013290677 1463 3128206
SGTC_386 1509-0011 3.07 µM 0.546085769651716 0.29816671193321 no 1022 0.292503490573141 1414 3107280
SGTC_2111 5486399 200 µM 0.545630127781479 0.298326457787909 no 1023 0.292660105193332 1411 689674
SGTC_3078 9116413 49.47 µM 0.545229191021055 0.298467056510448 no 1024 0.29279794861503 1340 17177322
SGTC_395 anisomycin 6.25 µM 0.544569737815278 0.298698376184486 no 1025 0.293024736410023 1380 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1908 st060353 56.5 µM 0.543686037858036 0.299008483726515 no 1026 0.293328770993043 1549 4227716
SGTC_1193 1488-0126 41.5 µM 0.543469968565001 0.299084328891477 no 1027 0.293403131285807 1427 1384710
SGTC_557 1315-0110 16.2 µM 0.541991299966016 0.29960360895077 no 1028 0.293912249632846 1385 6833801
SGTC_2258 7960471 200 µM 0.541519273864082 0.299769461447866 no 1029 0.294074858275661 1368 2974708
SGTC_2776 terbinafine 19.92 µM 0.541324320039181 0.299837973134398 no 1030 0.294142030203497 1398 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_140 0062-0056 502.533 µM 0.540823616150036 0.300013965573266 no 1031 0.294314581717994 1343 3758964
SGTC_869 0564-0080 44.1 µM 0.540077137655298 0.300276432085364 no 1032 0.294571918317551 1398 6843321
SGTC_2299 7976368 114.88 µM 0.539921578692273 0.300331140656032 no 1033 0.29462555786684 1518 2979718
SGTC_2368 9071271 200 µM 0.539556263058023 0.300459636310021 no 1034 0.294751543029427 1380 27209959
SGTC_2423 st077119 87.2 µM 0.537414347016055 0.301213530234526 no 1035 0.295490717640572 1366 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_279 1273-0055 2.93 µM 0.536966072397402 0.301371417998562 no 1036 0.295645524896475 1472 2847562
SGTC_1770 st043884 66.3 µM 0.536669123223517 0.301476027614057 no 1037 0.295748093911567 1429 670149
SGTC_1916 st067606 49.2 µM 0.535192422197665 0.301996484145871 no 1038 0.296258402872292 1515 19590279
SGTC_2725 haloperidol 53.21 µM 0.535187642037252 0.301998169546704 no 1039 0.296260055425328 1386 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1674 st016616 23.6 µM 0.534515876595004 0.302235064276096 no 1040 0.296492334019101 1376 625830
SGTC_2364 9055074 200 µM 0.532599516590714 0.302911316858535 no 1041 0.29715541842034 1402 6470630
SGTC_172 1112-0046 2.638 µM 0.531861020346599 0.303172100968426 no 1042 0.297411128151189 1444 2802135 YIL048W NEO1
SGTC_229 benomyl 22.8748 µM 0.529506757360121 0.304004127833317 no 1043 0.298226979042075 1420 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_796 1234-0020 70.7 µM 0.529280781836595 0.304084044012215 no 1044 0.298305342621718 1403 46495034
SGTC_1396 3511-0007 98.6 µM 0.52727581344279 0.304793510156231 no 1045 0.299001033862328 1417 X1396
SGTC_739 1486-1183 203 µM 0.525286009339599 0.305498336837012 no 1046 0.299692190873406 1477 4346692
SGTC_2316 5844804 197.44 µM 0.524691148071629 0.305709188284974 no 1047 0.299898955932303 1494 776813
SGTC_2826 7992541 19.48 µM 0.524321634455896 0.305840196618262 no 1048 0.30002742595288 1493 2985066
SGTC_2153 5569715 200 µM 0.523804378368295 0.306023627694384 no 1049 0.300207303895997 1466 2054701
SGTC_124 0136-0217 7.121 µM 0.523489250871587 0.306135403110134 no 1050 0.300316914681654 1555 3976905
SGTC_2880 9042983 58.44 µM 0.522652085241302 0.306432432594322 no 1051 0.30060819378346 1445 6464714
SGTC_715 0868-0130 184 µM 0.522413971806326 0.306516939376386 no 1052 0.30069106503853 1591 2876258
SGTC_2751 anetholtrithion 17.25 µM 0.522179240419884 0.306600255936332 no 1053 0.300772769320935 1515 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_3351 9150312 21.596 µM 0.521605773676757 0.30680384670367 no 1054 0.300972421252445 1447 4904905
SGTC_1488 4013-0813 75.9 µM 0.521247750485291 0.306930981454205 no 1055 0.301097096993303 1425 2910057
SGTC_299 1273-0059 1.44 µM 0.519286845941957 0.307627714146751 no 1056 0.301780362463495 1447 2848077
SGTC_622 1348-1566 26.3 µM 0.515708950435042 0.308900771342392 no 1057 0.303028851212726 1530 7340407
SGTC_1180 1193-0155 285 µM 0.514529852535916 0.309320812673541 no 1058 0.303440797247892 1433 2921347
SGTC_2698 st077697 67.5 µM 0.514272569733501 0.309412500142213 no 1059 0.303530718385749 1405 3154499
SGTC_1423 4048-0112 5.59 µM 0.514106480468527 0.309471695416119 no 1060 0.3035887734194 1529 X1423
SGTC_74 000s-0487 160.283 µM 0.513749901119695 0.30959879927089 no 1061 0.303713429322058 1368 677548
SGTC_532 1548-0774 215 µM 0.513712650601667 0.309612078651867 no 1062 0.303726452978192 1562 5932993
SGTC_758 0868-0029 16 µM 0.511756483602556 0.310309778554783 no 1063 0.304410724777388 1526 762687
SGTC_1054 3429-0080 167 µM 0.510970665095593 0.31059024646337 no 1064 0.304685798997839 1518 1162877
SGTC_831 k061-1017 217 µM 0.508866375172325 0.311341834384716 no 1065 0.30542294519635 1552 1240153
SGTC_1710 st031758 61.5 µM 0.507051392698088 0.311990722942379 no 1066 0.306059379591639 1553 5394341
SGTC_1543 azetidyl-2-carboxylic acid 198 µM 0.506822746614417 0.312072509440875 no 1067 0.3061395972918 1457 16486 A toxic proline analog.
SGTC_1748 st037455 53.6035 µM 0.505226382276381 0.31264378548586 no 1068 0.306699921181963 1514 580690
SGTC_686 1319-0111 510 µM 0.504251975416792 0.312992708868517 no 1069 0.307042160261129 1557 4562600
SGTC_2082 5219693 150 µM 0.502624329205446 0.31357592302905 no 1070 0.307614210378792 1456 2834649
SGTC_965 1291-5240 308 µM 0.501430296274062 0.314004062575743 no 1071 0.308034161188758 1575 2834598
SGTC_656 4090-1979 187 µM 0.499439520900145 0.314718443599748 no 1072 0.308734891624842 1574 22330961
SGTC_2448 5185112 27.17 µM 0.499030028442809 0.314865474322178 no 1073 0.308879114848752 1463 5718189
SGTC_2045 5106652 78.05 µM 0.498003207356902 0.315234289618631 no 1074 0.309240890766698 1525 673349
SGTC_1630 st005209 31.3 µM 0.495600096226955 0.316098162667592 no 1075 0.310088292451129 1517 3367314
SGTC_2272 7805186 180 µM 0.494569140281815 0.316469080201834 no 1076 0.310452145035141 1485 2956062 YPR165W RHO1
SGTC_1340 1486-1359 257 µM 0.494511058338877 0.31648998243342 no 1077 0.310472649267769 1510 4309068
SGTC_28 pentachloropyridine N-oxide 1.606 µM 0.493568114168964 0.316829406306585 no 1078 0.310805612129864 1493 140250 A respiratory chain inhibitor.
SGTC_1202 1988-0068 29.6 µM 0.49356421588819 0.316830809859053 no 1079 0.310806988973027 1431 2850480
SGTC_2680 butyl paraben 22.24 µM 0.493390429509195 0.316893383274318 no 1080 0.310868371693491 1506 7184 An antifungal and steroid mimetic.
SGTC_113 0099-0221 2.5 µM 0.492868260791945 0.317081426524499 no 1081 0.311052837466007 1575 89219
SGTC_1280 0880-0253 10.1 µM 0.492531449348221 0.317202744035448 no 1082 0.31117184754051 1471 6836607
SGTC_3296 9122258 64.045 µM 0.491207822734256 0.317679696810184 no 1083 0.31163973332932 1512 4730474
SGTC_920 mycophenolic acid 780.421 nM 0.491128096514873 0.3177084348591 no 1084 0.31166792529386 1491 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2780 5215298 71.43 µM 0.490372320191677 0.317980915918363 no 1085 0.311935229946443 1553 2834131
SGTC_1616 st002734 56.1 µM 0.489218949555909 0.318396932149359 no 1086 0.312343347585843 1523 4026101
SGTC_1097 itavastatin 7.23 µM 0.486336460996187 0.319437635297188 no 1087 0.313364316061099 1505 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_2278 7948257 134.34 µM 0.483418271185995 0.320492678917606 no 1088 0.314399388756493 1578 1247028
SGTC_167 3672-0051 66.205 µM 0.481441226091523 0.321208286510441 no 1089 0.315101471133361 1448 3237971
SGTC_1807 st050092 58.9 µM 0.480943905058275 0.32138840059809 no 1090 0.315278183625906 1485 5008496
SGTC_688 0527-0193 473 µM 0.479959249353013 0.321745135920895 no 1091 0.315628184838478 1543 4007154
SGTC_1988 st071872 53.4 µM 0.479735078760226 0.321826374673403 no 1092 0.31570789062219 1543 16414116
SGTC_1285 0929-0069 65.5 µM 0.479293840231174 0.321986303077207 no 1093 0.315864801818001 1521 1206237
SGTC_1775 st081588 35.1725 µM 0.479186623888053 0.32202516898584 no 1094 0.315902934608612 1505 1426443 YGL099W LSG1
SGTC_3310 9130229 44.1445 µM 0.478963213161922 0.322106161595145 no 1095 0.315982399632599 1565 7761258
SGTC_182 3448-4371 550.524 µM 0.477465564722145 0.322649318858758 no 1096 0.31651531804709 1631 3491403
SGTC_1140 3229-1848 2.98 µM 0.476835956354685 0.322877774195137 no 1097 0.316739469738629 1589 2849525
SGTC_2126 5251174 33.877 µM 0.476397668516932 0.323036847761612 no 1098 0.316895547683023 1675 790722
SGTC_2624 nerol 100 µM 0.475969645389384 0.323192227067313 no 1099 0.317048001735249 1594 637566 A natural product oil.
SGTC_151 3013-0144 2.285 µM 0.475581057693044 0.323333317394645 no 1100 0.317186436505851 1587 906558 YHR107C CDC12
SGTC_2249 haloperidol 116.36 µM 0.474414512142085 0.323757025057228 no 1101 0.317602173200788 1558 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_892 0929-0076 29 µM 0.473379673046593 0.324133086179594 no 1102 0.317971164636874 1504 5751038
SGTC_1893 st059353 36.1 µM 0.473362569638748 0.324139303076833 no 1103 0.317977264699821 1480 3112488
SGTC_543 3844-1095 191 µM 0.472491601651531 0.324455954987534 no 1104 0.318287967444498 1597 4230703
SGTC_2619 obliquin 87.91 µM 0.472020009241736 0.324627461634646 no 1105 0.318456253250584 1589 6708593 A bioactive alkalod. YER133W GLC7
SGTC_1432 4049-0298 68.4 µM 0.471504260886336 0.324815069301588 no 1106 0.318640338813493 1613 741646
SGTC_529 4076-0302 30.3 µM 0.469914830485118 0.325393516929233 no 1107 0.319207934099126 1503 5816522
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.469571108395425 0.32551866445243 no 1108 0.319330735163885 1537 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2233 sulbentine 40.3845 µM 0.467559551581981 0.326251456473297 no 1109 0.320049798063726 1513 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_2009 4012297 12.05 µM 0.466770295866289 0.326539158742104 no 1110 0.320332114987442 1509 45595307
SGTC_2210 7115885 190.385 µM 0.46443746241885 0.327390134212346 no 1111 0.321167177579565 1521 2927039
SGTC_1753 st043925 64 µM 0.463577620667135 0.327704015608814 no 1112 0.321475195605184 1568 670181
SGTC_269 exalamide 29 µM 0.462881865112118 0.327958087227765 no 1113 0.321724523515299 1574 3316 A derivative of salicylamide.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 0.462537660908381 0.328083810998052 no 1114 0.321847900723674 1542 6857784
SGTC_2989 9073649 71.4286 µM 0.461789494194412 0.328357152986569 no 1115 0.322116142760393 1583 21367202
SGTC_903 1134-0042 114 µM 0.461623003920738 0.328417992554497 no 1116 0.322175847536979 1508 701009
SGTC_1381 2324-0066 62.1 µM 0.460895609373289 0.32868385344154 no 1117 0.322436750986071 1568 10885928
SGTC_3144 9087057 49.47 µM 0.460744494734793 0.328739096349085 no 1118 0.322490964090046 1659 17249618
SGTC_1654 st012436 41.8 µM 0.460001494049128 0.32901076917904 no 1119 0.322757574050805 1552 4323132
SGTC_766 1391-0721 126 µM 0.4589863005276 0.329382113389752 no 1120 0.323122001921773 1646 1020919 YIL115C NUP159
SGTC_822 1487-0950 154 µM 0.457179426768735 0.330043459930438 no 1121 0.323771042234682 1566 1958375
SGTC_859 0439-0102 54.6 µM 0.456860997605012 0.330160065565973 no 1122 0.32388547961432 1594 610143
SGTC_2546 rhodinyl acetate 100 µM 0.455716788840586 0.330579199678578 no 1123 0.324296823795661 1639 6708682
SGTC_379 3970-0972 5.9 µM 0.454423174047394 0.331053318586893 no 1124 0.324762137965438 1571 2898042 YBL034C STU1
SGTC_499 genistein 192 µM 0.454179735647728 0.331142570794772 no 1125 0.324849733541109 1622 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_1403 3909-7815 62.9 µM 0.450842456108098 0.332367088407989 no 1126 0.326051549747369 1596 6615483
SGTC_2982 9019404 25.97 µM 0.44973417268407 0.332774137667541 no 1127 0.326451063933947 1382 22333232
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM 0.448381377403977 0.333271258229923 no 1128 0.326938989698197 1582 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1415 3966-0071 78.1 µM 0.447083570255476 0.333748447389659 no 1129 0.327407360613915 1566 2893185
SGTC_1657 st012939 43.4 µM 0.44679715819492 0.333853794162039 no 1130 0.327510761668856 1640 24207257
SGTC_2543 pimpinellin 60.67 µM 0.445688089494516 0.334261850213989 no 1131 0.32791128463942 1509 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_2972 9093619 59.92 µM 0.443574632700701 0.33503998968719 no 1132 0.328675074706947 1493 25236256
SGTC_11 0438-0307 1.3 µM 0.443536113344191 0.335054178455404 no 1133 0.328689002016988 1656 4011476
SGTC_1762 st045503 25.4615 µM 0.44249534456958 0.33543763909219 no 1134 0.329065399186535 1555 4645554
SGTC_1413 3910-0535 34.4 µM 0.441075348571678 0.335961098687397 no 1135 0.329579224620517 1641 2876951
SGTC_2969 9091408 28.7 µM 0.439580967426063 0.336512323025949 no 1136 0.330120313957964 1482 4286311
SGTC_2741 miltefosine 3.04 µM 0.439485794926241 0.336547440713257 no 1137 0.330154786313105 1563 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_39 0986-0283 58.349 µM 0.439460260503335 0.336556862898948 no 1138 0.330164035361366 1711 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_1706 st031321 9.9705 µM 0.437747856598232 0.337188972785844 no 1139 0.330784536886643 1645 6103185
SGTC_2690 usnic acid 100 µM 0.437403128767677 0.337316279898919 no 1140 0.330909507737334 1709 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1242 0402-0103 60.1 µM 0.436482854539662 0.337656226043155 no 1141 0.331243218136612 1526 432868
SGTC_2112 5488546 200 µM 0.435622616685869 0.337974114788319 no 1142 0.331555279352363 1537 600757
SGTC_1866 st057638 64 µM 0.435076812874347 0.338175868823202 no 1143 0.331753336648105 1581 688802
SGTC_762 1165-0429 115 µM 0.431985682417493 0.339319367483758 no 1144 0.332875909612039 1671 5967793
SGTC_1014 4130-3005 69.3 µM 0.431141860409298 0.339631779499884 no 1145 0.333182612467039 1552 743608
SGTC_457 grayanotoxin iii 135 µM 0.429914764988138 0.340086289189757 no 1146 0.333628822296582 1558 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_1496 4469-0713 57.4 µM 0.429481303756835 0.34024689655151 no 1147 0.33378649850562 1671 746691
SGTC_215 1287-0124 461.5 µM 0.429166663191451 0.340363496280373 no 1148 0.33390097080273 1677 5560863
SGTC_1984 st072354 53.1 µM 0.427852984697929 0.340850484994932 no 1149 0.334379079240922 1604 5762938
SGTC_945 3381-0768 11.3 µM 0.427538567005499 0.340967080953953 no 1150 0.334493550291505 1609 1126236 YIL048W NEO1
SGTC_2159 5658611 73.75 µM 0.426269710070484 0.341437767221402 no 1151 0.334955663343845 1643 793844
SGTC_1159 4092-0538 61.2 µM 0.424918283285221 0.341939354366374 no 1152 0.335448122965508 1629 717301
SGTC_1715 st032160 10.2275 µM 0.42293106121655 0.34267742610687 no 1153 0.336172779839113 1660 5289825
SGTC_3263 9137018 49.47 µM 0.421850970463956 0.343078833589273 no 1154 0.336566899546299 1501 43844957
SGTC_3234 9132280 49.47 µM 0.418636186767337 0.344274630229652 no 1155 0.337741019457889 1599 17612295
SGTC_1476 4112-3294 3.34 µM 0.417606421034868 0.344658000277787 no 1156 0.338117450670793 1690 704369
SGTC_576 1073-0113 22.7 µM 0.41612324425761 0.345210450484183 no 1157 0.338659910906351 1679 5439563
SGTC_2659 sanguinarine 24.21 µM 0.415531647271045 0.345430899278188 no 1158 0.338876376336677 1600 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2807 7945238 51.95 µM 0.415090577615604 0.345595290690648 no 1159 0.33903779842675 1641 17148797
SGTC_2331 7980721 200 µM 0.414498953845182 0.345815840970436 no 1160 0.339254366519855 1702 2981221
SGTC_146 3448-8650 53.125 µM 0.410728521394996 0.347222639886108 no 1161 0.340635805410329 1636 2891488 YIL048W NEO1
SGTC_2528 xanthyletin 44.79 µM 0.410648341591128 0.347252579000481 no 1162 0.340665205585536 1618 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1534 6-azauridine 81.6 µM 0.409465570659327 0.347694335961563 no 1163 0.341099014122026 1609 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_1399 3562-5772 25 µM 0.409459602820858 0.34769656543399 no 1164 0.341101203497777 1587 23847490
SGTC_18 0111-0177 500 nM 0.409303603747073 0.347754845627755 no 1165 0.341158435595349 1639 721752
SGTC_1856 st057054 55.7 µM 0.407811201897166 0.348312578485767 no 1166 0.341706144469744 1728 1266018
SGTC_542 3381-0244 89.3 µM 0.407439780883961 0.348451435111173 no 1167 0.341842507192853 1721 1112843
SGTC_863 0466-0191 129 µM 0.407400148275785 0.348466253055203 no 1168 0.341857059043404 1711 765160 YPR165W RHO1
SGTC_561 1550-0330 72.9 µM 0.407032094149831 0.348603873144855 no 1169 0.341992208193776 1581 6812934
SGTC_70 0141-0289 43.283 µM 0.406458222012533 0.348818490942152 no 1170 0.342202973929135 1696 352408
SGTC_2347 9049783 174.81 µM 0.406328453722358 0.348867028644689 no 1171 0.342250640682981 1677 6467988 YPL169C MEX67
SGTC_443 clozapine 122 µM 0.405713823683154 0.349096954527095 no 1172 0.342476441979963 1696 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_818 4072-2707 53.5 µM 0.405649320573906 0.349121087596984 no 1173 0.342500142242502 1549 882871
SGTC_3158 9100007 49.47 µM 0.405535370633528 0.349163722100701 no 1174 0.342542012181513 1576 19297233
SGTC_1422 4031-0024 15.5 µM 0.404702970070451 0.349475223464208 no 1175 0.34284792937094 1643 782427
SGTC_1319 1306-0155 43.7 µM 0.403644159595023 0.349871598560142 no 1176 0.343237203834409 1645 3122360
SGTC_1935 st074532 41.6 µM 0.402196051866629 0.35041397547325 no 1177 0.343769873813413 1765 2829742
SGTC_2774 tamoxifen 10.92 µM 0.402057544362078 0.350465868333185 no 1178 0.343820838501063 1631 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_535 2293-4129 48.2 µM 0.40095829631676 0.350877808636573 no 1179 0.344225414154847 1730 396118 YIL048W NEO1
SGTC_876 0720-0963 56.8 µM 0.400309145948537 0.351121158407677 no 1180 0.344464416208562 1757 765861
SGTC_1313 1220-0047 237 µM 0.400188785159021 0.351166285284397 no 1181 0.34450873707804 1696 3528706
SGTC_1201 1889-3372 45.9 µM 0.399508027950142 0.351421561105894 no 1182 0.344759454826325 1626 5392199
SGTC_255 tunicamycin 200.472 nM 0.399416027073294 0.351456065479926 no 1183 0.344793343288877 1740 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_602 3130-1533 38.1 µM 0.397779423348618 0.352070068166015 no 1184 0.34539639308479 1724 720941
SGTC_3297 9117502 71.43 µM 0.397253941635611 0.352267294437619 no 1185 0.345590104033169 1639 7453720
SGTC_126 0417-1624 672.48 µM 0.397032704502663 0.352350342090313 no 1186 0.345671671882544 1749 41912 YDL195W SEC31
SGTC_2721 ifenprodil 61.44 µM 0.39543602297173 0.352949910469005 no 1187 0.346260564146245 1713 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_993 3909-8757 62.7 µM 0.394580577155849 0.353271288518102 no 1188 0.346576225008837 1639 4288324 YLR208W SEC13
SGTC_2232 chlorophetanol 41.5365 µM 0.393434356087755 0.353702070474557 no 1189 0.346999349423983 1734 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1764 st044502 93.5 µM 0.393018414762024 0.353858439237307 no 1190 0.347152940262214 1614 8407
SGTC_860 0443-0016 25.1 µM 0.392411577731095 0.354086617451097 no 1191 0.347377066441103 1654 5337942
SGTC_1009 4106-0057 9.87 µM 0.390377211353876 0.35485194623749 no 1192 0.348128818245085 1704 2928005
SGTC_2419 paclitaxel 166.5 µM 0.389424263483221 0.355210647078423 no 1193 0.348481163081193 1669 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_301 4119-0100 24.5 µM 0.388710700537529 0.355479324649535 no 1194 0.348745082902554 1649 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_234 nsc-17383 10.7 µM 0.388544539778316 0.355541899410165 no 1195 0.348806549967435 1727 408974
SGTC_1290 0986-0249 10.2 µM 0.388027426008774 0.355736665065889 no 1196 0.348997868808748 1667 53329
SGTC_694 1315-0438 43.2 µM 0.386715352845012 0.356231013043652 no 1197 0.349483474442916 1695 6793154
SGTC_578 3460-0051 92 µM 0.385831256529313 0.356564249153387 no 1198 0.349810822473046 1755 2876744
SGTC_684 1140-0066 328 µM 0.385214169845499 0.356796908149177 no 1199 0.350039372947005 1631 6813534
SGTC_2845 9003024 42.97 µM 0.384807701190434 0.356950187350307 no 1200 0.350189946481687 1727 2990173
SGTC_506 n9-isopropylolomoucine 153 µM 0.384282286680384 0.357148355214659 no 1201 0.350384617592776 1810 6610355
SGTC_1352 1496-0991 99 µM 0.383311022162737 0.357514783453255 no 1202 0.350744583867687 1634 3000039
SGTC_2730 imipramine 71.33 µM 0.381813558863181 0.358079987669457 no 1203 0.351299830421306 1719 3696 A tricyclic antidepressant.
SGTC_91 0417-1751 58.384 µM 0.381622936558534 0.35815195871813 no 1204 0.351370534344557 1658 6795624
SGTC_2091 4-phenylthiadiazole 200 µM 0.380176207645727 0.358698347483387 no 1205 0.351907309614404 1666 270010
SGTC_3032 9089427 49.47 µM 0.379238905953437 0.359052494450495 no 1206 0.352255231409703 1624 17173707
SGTC_1008 4106-0037 6 µM 0.376203325302637 0.360200278459322 no 1207 0.35338287173476 1667 2905394
SGTC_1692 fluoroquinolonic acid 71 µM 0.371844738687329 0.361850508182477 no 1208 0.355004225781943 1703 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_948 3448-0295 75.3 µM 0.369655731919554 0.362680273006358 no 1209 0.355819509860646 1632 678569
SGTC_266 formosanin C 406 nM 0.36860431356625 0.363079053269756 no 1210 0.356211339943793 1699 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2181 6316240 54.2555 µM 0.366656887289318 0.363818061925877 no 1211 0.356937484510532 1607 12779990
SGTC_1606 st000094 49.2 µM 0.366054806570362 0.364046642017535 no 1212 0.357162089817688 1834 1242210
SGTC_1892 st058411 7.36 µM 0.365145563012978 0.364391928230108 no 1213 0.357501375572751 1761 3934738
SGTC_417 st075190 100 µM 0.364544589419855 0.364620209034004 no 1214 0.35772569173252 1794 222757
SGTC_251 melphalan 456.522 µM 0.362712462483476 0.365316441457653 no 1215 0.358409844559713 1778 460612 A DNA alkylator.
SGTC_3274 9138298 49.47 µM 0.362652479476043 0.36533924331255 no 1216 0.358432251113413 1660 17015756
SGTC_1520 flindersine 88 µM 0.362146674687322 0.365531538146635 no 1217 0.358621213037066 1835 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_3299 9121982 43.1275 µM 0.359957713991193 0.366364117552997 no 1218 0.359439378089503 1646 17594604 YPL160W CDC60
SGTC_448 monastrol 171 µM 0.35939767567459 0.366577231497164 no 1219 0.359648806640793 1714 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_1650 st011916 45.8 µM 0.358807759390226 0.366801759535035 no 1220 0.359869453766515 1793 242528
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM 0.358776979826714 0.366813475796512 no 1221 0.359880967567851 1658 2374 Ca(2+)-ATPase inhibitor.
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM 0.358489298438946 0.366922987907508 no 1222 0.359988587532418 1623 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_673 1082-0474 110 µM 0.357646242976301 0.367243977457778 no 1223 0.360304033663061 1654 3098046
SGTC_1938 st074717 56.4 µM 0.357010745124831 0.367486001745286 no 1224 0.360541880835679 1640 17250979
SGTC_2023 5144124 124 µM 0.355833599266127 0.367934447365946 no 1225 0.360982592596288 1667 2830192
SGTC_141 0443-0274 32.331 µM 0.355728751177594 0.367974399047803 no 1226 0.361021855646198 1813 1627241
SGTC_2444 5485484 36.41 µM 0.355608895642102 0.368020070969102 no 1227 0.361066740412516 1754 6790631
SGTC_3098 9119039 49.47 µM 0.354383318460444 0.36848719404071 no 1228 0.361525817193453 1692 17161528
SGTC_792 4534-1957 155 µM 0.354131021660715 0.3685833799533 no 1229 0.361620347318228 1728 1717904
SGTC_2772 vinpocetine 57.06 µM 0.354032563439516 0.368620918509172 no 1230 0.361657239764295 1755 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_1350 1495-0454 146 µM 0.353674173165379 0.368757570333341 no 1231 0.36179154000594 1775 1069057
SGTC_3138 9097216 49.47 µM 0.352912511575097 0.369048041917381 no 1232 0.362077015360778 1745 25237486
SGTC_118 0083-0097 135.343 µM 0.352609464403335 0.369163634516363 no 1233 0.362190620617808 1699 5207356
SGTC_2451 5856223 45.7 µM 0.350958013177717 0.369793762408206 no 1234 0.362809923943985 1653 2179896
SGTC_296 1222-0039 74.9 µM 0.350936709648467 0.369801893273688 no 1235 0.362817915233941 1649 5984176
SGTC_515 4092-1064 102 µM 0.350870440615387 0.369827186384294 no 1236 0.362842774175832 1831 717353
SGTC_1115 galangin 695.678 nM 0.350868965432687 0.36982774942833 no 1237 0.362843327555219 1813 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1437 4092-1038 11.6 µM 0.350410415796459 0.370002781023922 no 1238 0.363015355323364 1694 3977136
SGTC_1222 0366-0074 1.18 µM 0.349126078727466 0.37049316468295 no 1239 0.363497329461682 1837 286520
SGTC_1124 fisetin 1.16336 µM 0.348407436022388 0.370767647669558 no 1240 0.363767109410803 1670 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_3231 9132313 49.47 µM 0.347360969428673 0.371167459414606 no 1241 0.364160075899167 1727 4905967
SGTC_1671 st016596 74.5 µM 0.34646648399268 0.37150931569865 no 1242 0.364496084074719 1695 2829167
SGTC_328 k915-0120 63.5 µM 0.344062958535139 0.372428401485229 no 1243 0.365399469482062 1813 6624543
SGTC_2852 9023854 51.95 µM 0.34366056015538 0.372582346072056 no 1244 0.365550787484446 1774 19798528
SGTC_2339 9000433 200 µM 0.343457275704005 0.372660123860295 no 1245 0.365627238585669 1633 2988954
SGTC_393 acivicin 6.25 µM 0.342828872654833 0.37290058726605 no 1246 0.365863601790678 1709 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_749 1000-0129 128 µM 0.341102202921242 0.373561565890385 no 1247 0.366513321442769 1849 708470
SGTC_1994 st072947 40.9 µM 0.34078618828413 0.373682578365353 no 1248 0.366632274450648 1766 5286565 YDL195W SEC31
SGTC_1120 ficusin 1.78878 µM 0.339181476524322 0.374297267635246 no 1249 0.3672365113263 1819 6199 A DNA cross-linker.
SGTC_1932 st074806 40.9 µM 0.338095208635294 0.374713547094848 no 1250 0.36764572056234 1778 17251235
SGTC_937 3122-0005 46.7 µM 0.336876905345875 0.375180598877733 no 1251 0.368104847817516 1851 759535
SGTC_2988 9073640 71.4286 µM 0.336634131702624 0.37527369108185 no 1252 0.368196361530062 1752 9102229
SGTC_2607 solasodine 47.35 µM 0.334665673381205 0.376028769509332 no 1253 0.368938649177009 1685 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 0.334374324674257 0.37614056800169 no 1254 0.369048555731949 1777 279621
SGTC_13 0199-0087 65 µM 0.333941555501259 0.376306652592185 no 1255 0.369211830617282 1771 4589825
SGTC_2967 9089538 49.85 µM 0.332000500249306 0.377051856164722 no 1256 0.369944440633931 1915 728216
SGTC_1514 1189-1591 158 µM 0.33122852261066 0.377348358795079 no 1257 0.370235938573304 1800 767698 YMR146C TIF34
SGTC_692 k241-0027 77.8 µM 0.330904489272688 0.377472835689012 no 1258 0.370358315439763 1815 3600480
SGTC_2549 cedrol 20.94 µM 0.330629550714993 0.377578462883515 no 1259 0.370462161093633 1823 6708665 A sedative which affects the nervous system.
SGTC_1471 k673-0312 37 µM 0.330582218492816 0.377596648124413 no 1260 0.370480039660877 1799 24099884
SGTC_425 3825-7017 13.1 µM 0.330387138702395 0.37767160147227 no 1261 0.370553729141786 1786 3397440
SGTC_2298 7976326 193.81 µM 0.324863555111858 0.37979576867846 no 1262 0.372642170443044 1790 2235818
SGTC_1473 k844-0725 134 µM 0.323696600779224 0.380245003313907 no 1263 0.373083872303571 1782 54682906
SGTC_2679 rapamycin 1 nM 0.322712468943682 0.380623983620314 no 1264 0.373456504070602 1767 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_714 4296-0578 26.1 µM 0.321831776038672 0.380963227693719 no 1265 0.373790070077353 1867 1589775
SGTC_1613 st002381 52.1 µM 0.319778815509374 0.381754385728736 no 1266 0.374568003916829 1761 551167
SGTC_877 0771-0151 33.1 µM 0.319117060560222 0.382009514499328 no 1267 0.374818873515725 1775 6166523
SGTC_363 0455-0021 3.06 µM 0.318531771321534 0.382235205880932 no 1268 0.375040799317557 1731 4597466
SGTC_2020 4017018 200 µM 0.317414910262927 0.38266598583381 no 1269 0.375464397490555 1725 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_648 0375-0473 33.3 µM 0.316811883172607 0.382898637371807 no 1270 0.375693173436267 1776 1713139
SGTC_411 enrofloxacin 100 µM 0.316250132258855 0.383115402326311 no 1271 0.375906329385369 1923 71188 A bacterial gyrase inhibitor.
SGTC_1792 st045773 43.6 µM 0.316042307557864 0.383195605711158 no 1272 0.375985197907536 1749 2919270
SGTC_3237 9133362 49.47 µM 0.315809540453556 0.383285440773626 no 1273 0.376073538107646 1806 43845137
SGTC_1603 st002045 67.8 µM 0.314459429914113 0.383806631443882 no 1274 0.376586062485108 1867 5887985
SGTC_799 1310-0557 151 µM 0.314003509646917 0.383982680413028 no 1275 0.376759186587515 1789 5354492
SGTC_2251 lansoprazole 556 µM 0.313811618036916 0.384056784566079 no 1276 0.376832059949507 1689 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_1548 st061468 90.8 µM 0.31264039439216 0.38450917616547 no 1277 0.377276942573583 1852 390799
SGTC_1315 1237-0019 3.69 µM 0.312296873658327 0.384641892813079 no 1278 0.377407457892874 1838 825140
SGTC_2925 9010536 32.5 µM 0.311524288643219 0.384940424589438 no 1279 0.37770104059944 1819 2994177
SGTC_3044 9093193 49.47 µM 0.310677298398069 0.385267785408678 no 1280 0.378022978530274 1694 25236277
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 0.310064739200865 0.385504589849524 no 1281 0.378255862874648 1734 75037 A free radical scavenger.
SGTC_1259 0671-0132 43 µM 0.309470861906128 0.385734212957652 no 1282 0.378481686919151 1746 X1259
SGTC_601 0986-0029 62.9 µM 0.307827714280364 0.386369745703491 no 1283 0.379106715975518 1763 24747981
SGTC_3192 9110362 49.47 µM 0.307716960897628 0.386412593623576 no 1284 0.37914885631704 1792 16649480
SGTC_2711 st079103 59.1 µM 0.307396197406235 0.386536697406464 no 1285 0.379270911102228 1865 54693780
SGTC_614 0462-0418 107 µM 0.307095795090217 0.386652933950612 no 1286 0.379385229102595 1778 5188303
SGTC_504 lovastatin 124 µM 0.306494886145239 0.386885477909165 no 1287 0.379613936439139 1706 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_938 3126-1755 342 µM 0.306145140653289 0.387020843576214 no 1288 0.379747069782946 1906 1777771
SGTC_247 mechlorethamine 29.705 µM 0.305909335756583 0.387112117376522 no 1289 0.379836838799064 1793 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_3227 9130768 49.47 µM 0.305086103975807 0.387430817397209 no 1290 0.380150287214644 1824 17720899
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM 0.303643607405109 0.387989437970035 no 1291 0.380699712626533 1799 7104
SGTC_1439 4092-1168 46 µM 0.303382872598435 0.388090434790312 no 1292 0.380799048338665 1805 2886240
SGTC_2610 ononetin 44.17 µM 0.303030163293986 0.388227070397513 no 1293 0.380933437339183 1725 259632
SGTC_626 0214-0009 33 µM 0.299784287149208 0.389485133692532 no 1294 0.38217085072541 1858 3437874
SGTC_337 1315-0038 354 µM 0.294964113034358 0.391355511583747 no 1295 0.38401064715186 1778 1626437
SGTC_652 0437-0092 114 µM 0.294956036281071 0.39135864773843 no 1296 0.384013732148952 1756 3091274
SGTC_2202 7226349 200 µM 0.294778146540827 0.391427723044204 no 1297 0.384081680786278 1785 844334
SGTC_1568 digitonin 820 nM 0.29331667684689 0.391995347067479 no 1298 0.384640053839632 1972 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.290837018047122 0.392958953681648 no 1299 0.385587986094889 1797 91467 include heat shock
SGTC_2406 ethylparaben 405.7 µM 0.289778162478243 0.393370630054608 no 1300 0.385992977614395 1559 8434 A possible steroid mimic.
SGTC_1689 st020265 53.493 µM 0.289637362858543 0.39342538105191 no 1301 0.386046840082721 1910 5758320 YPR016C TIF6
SGTC_248 streptozotocin 5.23457 mM 0.28925115787602 0.39357557059679 no 1302 0.386194592902734 1913 5300 DNA alkylating agent.
SGTC_951 1171-0579 82.7 µM 0.288959833319052 0.393688872992192 no 1303 0.38630605765653 1742 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_3160 9100216 49.47 µM 0.288013481942534 0.394056991493137 no 1304 0.386668209322485 1893 17191039
SGTC_2552 juarezic acid 87.02 µM 0.287722689392447 0.394170125080584 no 1305 0.386779510247899 1828 1549512
SGTC_1052 3253-3998 198 µM 0.287088197369683 0.394417006816383 no 1306 0.387022394553557 1793 5450317
SGTC_1368 1852-0141 284 µM 0.286993122078961 0.394454004402065 no 1307 0.38705879330263 1804 2838987
SGTC_802 4112-3352 742 µM 0.286189795993103 0.394766648584851 no 1308 0.387366379334311 1910 704594
SGTC_400 oxethazaine 37.5 µM 0.285967048070292 0.394853351223856 no 1309 0.387451679958686 1792 4621 A local anesthetic.
SGTC_2183 6420625 130.508 µM 0.285821300836267 0.394910084851343 no 1310 0.387507496349811 1790 2897619
SGTC_300 r073-0011 5.04 µM 0.28581010335026 0.394914443681484 no 1311 0.387511784714412 1900 2735780
SGTC_3046 9092212 49.47 µM 0.285607535590387 0.394993299228346 no 1312 0.387589365605477 1793 25236637
SGTC_581 0958-0271 211 µM 0.285506209962563 0.395032744867446 no 1313 0.387628173724241 1755 4591145
SGTC_1902 st060212 70.5 µM 0.285438155094871 0.395059238944064 no 1314 0.387654239639726 1813 688944
SGTC_2025 5147754 141 µM 0.284663437595876 0.395360874241952 no 1315 0.387951002363914 1905 315777 YLR208W SEC13
SGTC_1552 6-methylflavone 10.6 µM 0.282457812606593 0.396219974397429 no 1316 0.388796245360474 1916 689013
SGTC_2755 lomerizine 42.69 µM 0.282330271497596 0.396269667653691 no 1317 0.388845138006875 1750 3949 A calcium channel blocker.
SGTC_3179 9107801 49.47 µM 0.282149754017914 0.396340004730529 no 1318 0.388914342055467 1768 4818259
SGTC_1223 0764-0573 147 µM 0.279282809510914 0.397457535766501 no 1319 0.39001389883051 1808 1609797
SGTC_1750 st081859 2.357 µM 0.27442070526236 0.399354698222536 no 1320 0.391880666519418 1847 5291695
SGTC_2449 5812982 45.77 µM 0.273605149492698 0.399673157180145 no 1321 0.392194038119099 1831 776185
SGTC_1789 tunicamycin 25 nM 0.27081276819707 0.400764033091617 no 1322 0.393267519560356 1953 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_2188 6126565 140.678 µM 0.270045375896027 0.401063959734233 no 1323 0.393562672495963 1914 874518
SGTC_344 k064-0035 6.43 µM 0.269294240266743 0.401357589119967 no 1324 0.393851632064193 1752 5088750
SGTC_292 k038-0015 474 µM 0.268976845584467 0.401481679879329 no 1325 0.393973750400776 1882 46368540
SGTC_1550 gossypolone 36.6 µM 0.268648623087808 0.401610014404033 no 1326 0.394100045729289 1891 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2640 pentamidine 10.38 µM 0.26726301929093 0.402151900305135 no 1327 0.39463332887297 1968 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_1167 k781-0610 148 µM 0.266005304813785 0.402643933795943 no 1328 0.395117561760311 1833 4525169
SGTC_1808 st050063 61.5 µM 0.265028898724533 0.403026022359695 no 1329 0.395493599811837 1922 4011993
SGTC_738 1315-0003 72.4 µM 0.264703936176763 0.403153207706957 no 1330 0.395618772500252 1924 6251474
SGTC_2235 salicylic acid 500 µM 0.264380408663796 0.40327984158211 no 1331 0.395743403122474 1904 338 A COX inhibitor and kinase inhibitor.
SGTC_3348 9149464 3.537 µM 0.26437904213078 0.403280376486646 no 1332 0.395743929566658 1889 1951442
SGTC_2356 9061756 188.97 µM 0.263861476961471 0.403482980978972 no 1333 0.39594333042236 1964 20104043
SGTC_38 0929-0051 58.268 µM 0.260982751398258 0.404610349484688 no 1334 0.397052904408862 1992 1379719
SGTC_1355 1499-0035 1.68 µM 0.260725464490888 0.404711147073436 no 1335 0.397152113620052 1820 1548538
SGTC_2582 agaric acid 100 µM 0.260096611823477 0.404957540012958 no 1336 0.397394625692699 1792 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_1962 st076595 64.5 µM 0.25853280020697 0.405570425626304 no 1337 0.397997869100971 1833 279619
SGTC_939 1165-0479 45.3 µM 0.258315828050581 0.405655479205425 no 1338 0.398081585839141 1984 1377347
SGTC_480 am 92016 50 µM 0.25580201983071 0.406641221522033 no 1339 0.399051857094484 1820 2129 K+ channel blocker.
SGTC_2381 9035592 200 µM 0.255436859729757 0.406784461523415 no 1340 0.399192852415108 1780 4749657
SGTC_2041 5107442 45.335 µM 0.254910504163917 0.406990955013334 no 1341 0.399396111534865 1957 793005
SGTC_323 4013-0906 34.3 µM 0.253958592797994 0.407364463069687 no 1342 0.399763773847871 1987 2910086
SGTC_1931 st074438 57.1 µM 0.253384349157605 0.407589823784508 no 1343 0.399985610345468 1949 2787313
SGTC_2343 7990716 14.84 µM 0.25315392369054 0.407680262379777 no 1344 0.400074635262201 1900 6456862
SGTC_880 0833-0487 87.2 µM 0.253099176266634 0.407701750659257 no 1345 0.40009578770203 1811 76075
SGTC_3028 9087778 49.47 µM 0.25291856543026 0.407772642102833 no 1346 0.400165571325566 1802 17217395
SGTC_659 k018-0002 107 µM 0.252779254130696 0.407827325154819 no 1347 0.400219399992866 1985 6797879 YHR007C ERG11
SGTC_718 1130-0073 349 µM 0.251383440658674 0.408375314633814 no 1348 0.400758834588708 1915 6740020
SGTC_2472 5377652 49.4 µM 0.249835523851346 0.408983228678605 no 1349 0.401357273307004 1836 1610903
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.249653323447586 0.409054798756897 no 1350 0.401427728893166 1912 4000243
SGTC_911 3456-4043 236 µM 0.249604486063607 0.409073983068377 no 1351 0.401446614503166 1916 914281
SGTC_1200 1643-0193 18.4 µM 0.249526772714797 0.409104510891475 no 1352 0.401476667037866 1975 5403974
SGTC_531 3788-1495 174 µM 0.249312936459765 0.409188514174906 no 1353 0.401559362678845 1820 2896655
SGTC_1569 carminic acid 40.6 µM 0.249178189429961 0.409241450245192 no 1354 0.401611474872156 1988 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_697 0508-1955 564 µM 0.247802215296843 0.409782103406859 no 1355 0.402143720411057 1996 6243113
SGTC_1817 st052116 64.4 µM 0.246061016214059 0.410466508021276 no 1356 0.402817499987598 1956 4361398
SGTC_1576 erythromycin ethylsuccinate 23.2 µM 0.245715277513242 0.410602438364347 no 1357 0.40295132248312 1879 3256 An antibiotic and ribosome inhibitor.
SGTC_2394 5221648 200 µM 0.245702285929612 0.410607546334114 no 1358 0.402956351260047 1952 788586
SGTC_1345 1488-0192 31.4 µM 0.244402009402493 0.411118859503972 no 1359 0.403459742840418 1974 658348
SGTC_719 2810-4230 27.3 µM 0.243906483704346 0.411313756937722 no 1360 0.40365162377065 1896 721079
SGTC_2155 5570423 76 µM 0.242398465523838 0.411907016805857 no 1361 0.404235711632112 1862 797402
SGTC_2360 9040895 200 µM 0.239474869423373 0.413057742802427 no 1362 0.405368690456795 1847 4914414
SGTC_3206 9114350 49.47 µM 0.23946349394935 0.4130622216495 no 1363 0.405373100340678 1984 17087243
SGTC_441 propafenone 146 µM 0.239404888939557 0.413085296284956 no 1364 0.405395819697508 1879 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_1138 3761-0006 1.03 µM 0.239251875995288 0.41314554370852 no 1365 0.405455139604504 1948 12061087
SGTC_1067 clotrimazole 1.36 µM 0.238709915337191 0.413358952120338 no 1366 0.405665263835773 1867 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_654 1124-0271 80.9 µM 0.238073820679394 0.41360946042671 no 1367 0.405911919550012 1813 5403748
SGTC_2593 nobiletin 86.24 µM 0.236962073844973 0.414047375585962 no 1368 0.406343106524938 1831 72344 An anti-infammatory.
SGTC_2061 5245884 80.95 µM 0.236420830392112 0.41426060916952 no 1369 0.406553066982662 1863 573863
SGTC_2454 5-benzylidenerhodanine 10.36 µM 0.235453091992639 0.414641931846241 no 1370 0.406928541312928 2023 1273210
SGTC_2315 7733312 200 µM 0.235062958874235 0.414795680674373 no 1371 0.407079933888554 1846 726316
SGTC_3143 9086658 49.47 µM 0.23487263613253 0.414870690320448 no 1372 0.407153794360866 1846 25236626
SGTC_1085 doxorubicin 7.67 µM 0.234320001001708 0.415088511434581 no 1373 0.407368279771977 1993 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2157 5649910 96.377 µM 0.233388799004773 0.41545560368124 no 1374 0.407729755072354 1824 2858091
SGTC_1873 rapamycin 2 nM 0.232170271860848 0.41593607476417 no 1375 0.408202883278901 1870 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_228 caffeine 993.056 µM 0.232144123911196 0.415946386405747 no 1376 0.408213037441857 1989 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1768 st044301 37.178 µM 0.230875621800633 0.41644669916723 no 1377 0.408705715057054 1863 3931349
SGTC_2431 5490079 200 µM 0.230792035417753 0.416479671423524 no 1378 0.408738184517238 1861 5722345
SGTC_1325 1431-0015 227 µM 0.229158891343698 0.417124014149567 no 1379 0.409372711187863 1829 1103340
SGTC_1480 1070-0044 41.2 µM 0.228431350822243 0.417411130699088 no 1380 0.40965545961133 1982 3124987
SGTC_162 k030-0015 37.8 µM 0.228041523047862 0.41756499044029 no 1381 0.409806980055772 2007 1809920 YMR134W ERG29
SGTC_1581 himbacine 57.9 µM 0.228018437499992 0.417574102389351 no 1382 0.409815953498609 1868 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_2405 ticlatone 3.52 µM 0.226158190490347 0.418308493657481 no 1383 0.41053919365798 1693 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_1388 3346-4487 254 µM 0.225826915369543 0.418439304931812 no 1384 0.410668021165205 1964 3345614
SGTC_1475 4092-1048 11.7 µM 0.225622082446208 0.418520192235051 no 1385 0.410747682180988 1915 2881759
SGTC_509 pifithrin 175 µM 0.225413812604999 0.418602440289376 no 1386 0.410828683613931 1952 4817 A p53 inhibitor.
SGTC_2723 salbutamol 83.58 µM 0.224948236898089 0.418786314127989 no 1387 0.411009771583053 1998 9884233 β2-adrenoceptor agonist
SGTC_1016 4226-1401 38 µM 0.224762646549889 0.418859615877093 no 1388 0.411081963154228 2013 2901613
SGTC_2302 7771753 200 µM 0.223376616030379 0.419407138759705 no 1389 0.411621201131796 1827 2203047
SGTC_3140 9094243 49.47 µM 0.222615089656342 0.419708030615231 no 1390 0.41191754564536 2091 19291112
SGTC_1891 st059073 26.2 µM 0.222545119068475 0.419735679526857 no 1391 0.411944776903113 2048 688754
SGTC_2940 9060638 45.86 µM 0.222132490658859 0.419898737895913 no 1392 0.412105372862442 1906 4027022
SGTC_364 0083-0097 67.7 µM 0.22191676409349 0.419983992038968 no 1393 0.412189340016735 1891 5207356
SGTC_2367 9070478 135.38 µM 0.22135213006779 0.420207150566052 no 1394 0.412409131285854 1879 572802
SGTC_2796 7949634 45.45 µM 0.220694108512919 0.420467250716466 no 1395 0.412665309545515 1886 2971588
SGTC_438 sphingosine 6.67 µM 0.219807828192406 0.420817630958703 no 1396 0.413010411357441 1740 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_52 0329-0193 875 nM 0.219676960869099 0.420869373099793 no 1397 0.413061374471481 1990 3739292
SGTC_847 0342-0274 5.54 µM 0.218322128801068 0.421405124898734 no 1398 0.413589067001334 2027 18097
SGTC_10 0279-0212 42.575 µM 0.216681118502189 0.422054237200323 no 1399 0.414228431843086 1966 39851 YBR002C RER2
SGTC_3221 9128209 49.47 µM 0.21613811520391 0.422269072411387 no 1400 0.414440045087134 1914 16460723
SGTC_1752 st044819 83.042 µM 0.215771603164255 0.422414093248537 no 1401 0.414582892152071 1882 441209 YML126C ERG13
SGTC_1278 0874-0585 172 µM 0.214736948933985 0.422823540102674 no 1402 0.414986206708862 1965 766306
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 0.214654900338754 0.422856013016218 no 1403 0.415018193594437 1882 442882
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.213897327464808 0.423155867364081 no 1404 0.415313562190175 1971 165521
SGTC_2862 9027634 71.43 µM 0.213447371099511 0.423333985337956 no 1405 0.415489017459429 1825 5012562
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 0.212052344307729 0.423886314651387 no 1406 0.416033098951943 1956 6708739 YPR165W RHO1
SGTC_1177 0983-0204 23.6 µM 0.211157097646314 0.42424084617683 no 1407 0.416382343516761 2063 766818
SGTC_872 0588-0139 234 µM 0.207002798483697 0.425886810866503 no 1408 0.418003836480853 1940 2047100
SGTC_3239 9133757 49.47 µM 0.205794872780744 0.426365643897731 no 1409 0.418475573204623 1992 17036923
SGTC_3167 9103034 49.47 µM 0.20460059921411 0.426839171830725 no 1410 0.418942093600283 2002 5127859
SGTC_409 arachidonic acid 100 µM 0.204495983919303 0.426880656693851 no 1411 0.418982965027889 1941 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_226 1,3-diallylurea 8.28947 mM 0.204094633370617 0.427039818479546 no 1412 0.419139774012403 1983 74537 YKL182W FAS1
SGTC_2692 st077426 47.7 µM 0.204047609740775 0.427058467207259 no 1413 0.419158147140973 2035 25238571
SGTC_2584 androsterone 48.74 µM 0.202873932829564 0.42752397911444 no 1414 0.419616784590741 2044 2754130 A steroid.
SGTC_2900 5328528 85.29 µM 0.202057904322123 0.427847697537525 no 1415 0.419935728261353 1966 795359
SGTC_338 4055-0136 114 µM 0.201821393064662 0.427941530617161 no 1416 0.420028178215398 1901 2900563
SGTC_3311 9131146 2.8755 µM 0.199504331954168 0.428861012273831 no 1417 0.42093412752864 1958 4900406 YPR165W RHO1
SGTC_764 1951-2361 146 µM 0.199187545562347 0.428986753053821 no 1418 0.421058020711404 1863 5438930
SGTC_3085 9117376 49.47 µM 0.198784317093418 0.429146815372198 no 1419 0.421215732158886 1969 16480349
SGTC_3262 9137218 49.47 µM 0.196219642276065 0.430165139633664 no 1420 0.42221912729049 2009 17650664
SGTC_2132 5317594 122.667 µM 0.1955433686573 0.430433737077276 no 1421 0.422483794817175 1965 794577
SGTC_187 1488-2104 32.728 µM 0.194985369062191 0.430655383546494 no 1422 0.422702200792756 2049 2852859
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.194972835578769 0.43066036230006 no 1423 0.422707106782123 1932 688667
SGTC_667 1498-1044 59 µM 0.19494034425407 0.430673269082354 no 1424 0.422719824937783 1961 6739982
SGTC_2380 9035439 200 µM 0.194911706490266 0.430684645146002 no 1425 0.422731034751828 2027 6462575
SGTC_3005 9076496 71.4286 µM 0.194755142472117 0.430746839644166 no 1426 0.422792320444804 2078 21368410
SGTC_1301 naphtanilide LB 4.81 µM 0.193871796214691 0.431097777937863 no 1427 0.423138134021638 2054 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_273 hydroxyurea 18.1 mM 0.192593806640773 0.431605597468659 no 1428 0.423638547853735 1954 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_560 2332-1943 155 µM 0.19157418654547 0.432010832913814 no 1429 0.424037882059816 1994 21177716
SGTC_1688 st021091 57.6 µM 0.189395616527201 0.432876917951649 no 1430 0.424891379901105 2094 3656366
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM 0.188848568447037 0.43309444636846 no 1431 0.425105752275113 2080 688662
SGTC_1247 0448-0043 5.84 µM 0.188273731560859 0.433323046580551 no 1432 0.425331038144014 1949 3089013 YGL099W LSG1
SGTC_2617 dihydrotanshinone i 20.83 µM 0.187974212410087 0.433442167722466 no 1433 0.425448433166285 1949 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_1838 st055369 84.5 µM 0.187878776041451 0.433480124793998 no 1434 0.425485840359251 2078 676036
SGTC_1 0258-0098 57.368 µM 0.186162330384441 0.434162896117176 no 1435 0.426158731764816 1967 6790032 YDR047W HEM12
SGTC_204 PMA1.184 62.41 µM 0.18613609126474 0.434173335098483 no 1436 0.426169019856899 2051 2252213 YGL008C PMA1
SGTC_2318 6029776 164 µM 0.184838925148 0.434689457241561 no 1437 0.42667768800982 2013 818325
SGTC_533 1222-0222 6.71 µM 0.183987558031039 0.435028263487226 no 1438 0.427011607777007 2067 3982874
SGTC_2775 cyproheptadine 69.59 µM 0.183795291903657 0.435104783466978 no 1439 0.427087024868702 2096 2913 A selective serotonin reuptake inhibitor.
SGTC_1610 st001799 48.1 µM 0.18244929621543 0.435640544083743 no 1440 0.427615071086377 1911 621897
SGTC_3042 9091578 49.47 µM 0.181222203490095 0.436129079500215 no 1441 0.428096583638068 2078 25236497
SGTC_1253 0550-0034 176 µM 0.181066864652421 0.436190930629402 no 1442 0.428157546421799 1980 5969915
SGTC_1267 0828-0272 9.49 µM 0.180145022811944 0.436558011645119 no 1443 0.428519358822835 2081 745334
SGTC_1150 3909-7983 10.9 µM 0.18002256570765 0.436606778659769 no 1444 0.428567426366398 1955 23965914
SGTC_1884 5633444 25 µM 0.179564860606185 0.436789062533424 no 1445 0.428747096694696 2009 5724239
SGTC_1190 1486-1332 13 µM 0.178014748246185 0.43740650380047 no 1446 0.429355696653883 2072 4150046
SGTC_971 1315-0384 26.7 µM 0.176920818932127 0.437842329941626 no 1447 0.429785292717356 1926 6769120
SGTC_2094 5332512 191.667 µM 0.176839905166618 0.437874569335391 no 1448 0.429817071603117 2072 755774
SGTC_1612 st002233 45.4 µM 0.176525741011037 0.437999749247537 no 1449 0.429940463900622 2102 1035021
SGTC_109 0132-0036 33.701 µM 0.176338245157747 0.438074460646278 no 1450 0.430014108739982 2107 67274 A color developer.
SGTC_3083 9117465 49.47 µM 0.1762774347029 0.438098692238417 no 1451 0.430037994464222 1931 16420915
SGTC_902 1120-0002 2.07 µM 0.174493762717225 0.438809548090477 no 1452 0.430738716102537 2065 3280475
SGTC_1847 st056231 15 µM 0.174402305736414 0.43884600224566 no 1453 0.430774651187482 2078 5393180
SGTC_134 0269-0018 6.916 µM 0.17417696997915 0.43893582181966 no 1454 0.43086319208554 1957 4378915
SGTC_2196 6573537 42.6665 µM 0.174148722875316 0.43894708143005 no 1455 0.430874291430028 2108 2903087
SGTC_1389 3405-0187 19 µM 0.172753553257103 0.439503272890369 no 1456 0.431422573574411 1937 799890
SGTC_235 0330-0087 5 mM 0.170789851375392 0.440286314748365 no 1457 0.432194504628614 1996 46494818 YHR062C RPP1
SGTC_3334 9142812 21.919 µM 0.170545938654342 0.440383593271893 no 1458 0.432290404837483 2050 45283678
SGTC_871 0574-0004 149 µM 0.170448193368021 0.440422577559021 no 1459 0.4323288368902 1972 9551173
SGTC_800 3448-7362 155 µM 0.169122453450692 0.44095138654179 no 1460 0.432850162010483 2135 15991913
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM 0.168675667436965 0.441129623591826 no 1461 0.433025879542829 1943 803109
SGTC_49 0717-0965 32.132 µM 0.168435080858696 0.441225606117225 no 1462 0.433120505897224 2072 5889349 YGL099W LSG1
SGTC_2378 9074213 121.43 µM 0.168402083905938 0.441238770590807 no 1463 0.433133484398932 2103 657714
SGTC_814 3342-0569 96 µM 0.16751949411631 0.441590912909345 no 1464 0.43348065508517 2078 4346283
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 0.167501412438211 0.441598127757011 no 1465 0.433487768132549 2053 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1232 0279-0259 161 µM 0.166004171625009 0.442195615225958 no 1466 0.434076833621714 1959 1560000
SGTC_2416 tofa 880 nM 0.164986272809607 0.442601892127762 no 1467 0.434477393349007 1857 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2018 5133068 143 µM 0.164249234421217 0.442896106100021 no 1468 0.434767471948959 2028 785362
SGTC_1358 1509-0022 2.48 µM 0.164232971236783 0.442902598459614 no 1469 0.434773873100013 2020 3258434
SGTC_1363 1636-0063 10.4 µM 0.163147390200665 0.443336003423383 no 1470 0.435201193815387 2015 6072185
SGTC_2634 4'-methoxyflavone 100 µM 0.161575246447611 0.443963782661235 no 1471 0.435820175808796 1980 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_1734 st037168 69.4 µM 0.160517342133916 0.444386298072331 no 1472 0.436236780852052 1943 708907
SGTC_2107 5363541 170.161 µM 0.160438417713144 0.444417822162249 no 1473 0.436267864304036 2126 244052
SGTC_695 3505-6186 243 µM 0.160391820988806 0.444436434048697 no 1474 0.436286216058975 2057 1819379
SGTC_2000 st075254 36.4 µM 0.156993980169684 0.445793943464636 no 1475 0.437624796200342 2026 17234175
SGTC_953 1188-0045 9.7 µM 0.153721467448777 0.447101982850968 no 1476 0.43891467869676 2063 6144426
SGTC_2951 9072950 58.06 µM 0.153177626806112 0.44731941478495 no 1477 0.439129100333272 2158 16488155
SGTC_245 methotrexate 289.6 µM 0.152667428183821 0.447523410760312 no 1478 0.439330274073083 2076 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_636 0kpi-0074 126 µM 0.152487800846996 0.447595235613114 no 1479 0.439401105717439 2031 616434
SGTC_3285 9112818 20.8695 µM 0.151428330047553 0.448018904978752 no 1480 0.439818921494613 2107 17017947 YPR165W RHO1
SGTC_2467 5474540 200 µM 0.151270550591419 0.448082004131274 no 1481 0.439881149574929 2124 5413519
SGTC_1929 genistein trimethyl ether 50.5 µM 0.15055034480228 0.448370045455939 no 1482 0.440165216952072 2175 136420
SGTC_2387 9077560 195.08 µM 0.150399611244802 0.448430333749622 no 1483 0.440224673981941 1993 5303272
SGTC_160 3453-0671 289.699 µM 0.149450516499878 0.448809966653841 no 1484 0.440599076435516 2081 5322268
SGTC_416 estradiol valerate 100 µM 0.14922723283132 0.448899285770223 no 1485 0.440687165943561 2035 13791 A steroid.
SGTC_1287 0971-0001 34.6 µM 0.148199356393002 0.449310495684529 no 1486 0.441092719866803 2059 4665869
SGTC_1227 3909-8010 46.6 µM 0.147023996745042 0.449780774098128 no 1487 0.441556539738857 2057 15982272
SGTC_3096 9117468 49.47 µM 0.14567683683599 0.450319879004341 no 1488 0.442088253900537 2153 41316311
SGTC_1836 st055642 81 µM 0.144457930268746 0.450807738669281 no 1489 0.442569437361351 1954 8571
SGTC_598 3937-0236 20.2 µM 0.143316250728368 0.451264756131724 no 1490 0.443020211045428 2111 1379313
SGTC_3222 9128301 49.47 µM 0.142485758745717 0.451597244985696 no 1491 0.443348163737152 2084 4911358
SGTC_1130 3454-2858 15.9 µM 0.142277684909229 0.451680553022733 no 1492 0.443430336031005 1964 715628 YIL048W NEO1
SGTC_2402 5553605 200 µM 0.142087508778451 0.451756697086333 no 1493 0.443505442310227 2108 6758546
SGTC_2513 baicalein 25.65 µM 0.14041686949931 0.452425675418886 no 1494 0.444165314983018 2024 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2738 aclarubicin 5.55 µM 0.140407913007575 0.452429262255355 no 1495 0.444168853056093 2122 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.139945719269729 0.452614363803924 no 1496 0.444351438972549 2022 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_852 0418-0143 439 µM 0.139475354672994 0.452802748229921 no 1497 0.44453726484626 2175 5369229
SGTC_2290 7904846 200 µM 0.139070014348246 0.452965098488183 no 1498 0.444697411509725 2027 2962154
SGTC_1337 1486-1011 40.3 µM 0.139055639186446 0.452970856291368 no 1499 0.444703091185073 2179 X1337
SGTC_885 0865-0106 16.8 µM 0.137290983414511 0.453677743292062 no 1500 0.445400398572029 2122 2793380
SGTC_1778 st046819 58.9 µM 0.136913636558087 0.453828920275927 no 1501 0.44554952996469 2064 671715
SGTC_1088 bifonazole 369 nM 0.136137688797283 0.45413981028083 no 1502 0.445856216759128 2147 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_992 3909-8734 162 µM 0.135586898436308 0.454360506140909 no 1503 0.44607393166586 2045 4288319
SGTC_1834 st055981 52.8 µM 0.135535607811273 0.454381058468981 no 1504 0.446094206512331 2159 471719 YDL150W RPC53
SGTC_2786 7743617 45.45 µM 0.135295007156347 0.454477469599932 no 1505 0.446189316247999 2014 583674
SGTC_3309 9129340 25.759 µM 0.135076976654936 0.454564838957241 no 1506 0.446275506648328 2107 17158987
SGTC_2087 5276107 200 µM 0.135039197895964 0.454579977915384 no 1507 0.446290441359851 2140 144405
SGTC_1714 st033236 13.627 µM 0.134343134421438 0.454858920931672 no 1508 0.446565623015906 2127 2916566
SGTC_2586 curcumin 80 µM 0.133271487283646 0.455288420186081 no 1509 0.446989338137557 2139 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_1164 k060-0068 93.7 µM 0.13284259089569 0.455460329760381 no 1510 0.447158935087825 2185 5963676
SGTC_571 k831-0106 44.2 µM 0.132353000003688 0.455656577002259 no 1511 0.447352544056078 2197 4783639
SGTC_927 2425-1185 123 µM 0.131411918730497 0.456033829653141 no 1512 0.447724730322002 2043 730375
SGTC_1081 sertraline 6 µM 0.131058027935871 0.45617570465709 no 1513 0.447864701779714 2177 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_2570 licareol 100 µM 0.130917689907088 0.456231967794216 no 1514 0.447920210301803 2029 443158
SGTC_2479 5617353 43.85 µM 0.130837928494092 0.456263945457406 no 1515 0.447951759141357 2124 2731746
SGTC_1075 aripiprazole 15.2 µM 0.129712142151787 0.456715321850352 no 1516 0.448397087842558 2086 60795 An atypical antipschotic. YIL048W NEO1
SGTC_1331 1472-0049 76.2 µM 0.129193442808274 0.456923309662764 no 1517 0.448602292304773 2092 24051409
SGTC_271 rotenone 740 µM 0.127136406869604 0.457748254586591 no 1518 0.449416218367873 2113 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_319 1348-1596 45.5 µM 0.126585636064797 0.457969164408683 no 1519 0.449634183118502 2183 5380505
SGTC_3272 9137413 49.47 µM 0.126491004318644 0.458007121764083 no 1520 0.449671634683421 2210 17614870
SGTC_998 3996-0085 177 µM 0.12544288701494 0.458427553373278 no 1521 0.450086468656652 2148 715391
SGTC_919 tnp00227 403.569 nM 0.124983507431404 0.458611839132109 no 1522 0.450268303556821 2088 1269246 A methoxyflavone. YNL221C POP1
SGTC_2437 5741531 144.16 µM 0.122489905139095 0.459612332491459 no 1523 0.451255520161678 2189 2262990
SGTC_2867 9039098 71.43 µM 0.122151909198691 0.45974796443939 no 1524 0.451389356024485 2191 6463460
SGTC_2978 9011784 42.97 µM 0.121243060392566 0.460112692997483 no 1525 0.451749259202181 2204 2994934
SGTC_2879 9041815 71.43 µM 0.120900302151304 0.460250253453252 no 1526 0.451885001422549 2207 4942971
SGTC_195 4234-0266 16.654 µM 0.120838885874236 0.460274902382118 no 1527 0.451909324647085 2069 2303354
SGTC_116 0155-0182 31.788 µM 0.119301059388359 0.460892146196323 no 1528 0.452518422112228 2043 771486
SGTC_320 4092-0846 5.34 µM 0.118932128345235 0.461040239655159 no 1529 0.452664563831567 2172 1359356
SGTC_1844 rapamycin 4 nM 0.117738601762156 0.461519372817325 no 1530 0.453137389851229 2080 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2506 ethyl hematommate 54.16 µM 0.11746375646804 0.461629715536606 no 1531 0.453246281660908 2010 3940691 An allergen.
SGTC_1793 st048256 72.231 µM 0.116685166740358 0.461942313601971 no 1532 0.453554772599016 2214 672022
SGTC_390 dec-rvkr-cmk 16.7 µM 0.116406240883724 0.462054306017742 no 1533 0.453665294755578 2125 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_1307 1187-1599 12.2 µM 0.115431679777129 0.462445628737394 no 1534 0.454051484976209 2103 1538471
SGTC_359 0081-0058 15.9 µM 0.115172762523716 0.462549599821911 no 1535 0.454154093672539 2182 3494159
SGTC_2824 7998404 51.95 µM 0.114308558426717 0.462896649011372 no 1536 0.454496599163915 2139 837851
SGTC_2206 7254556 146.969 µM 0.114217701759274 0.462933137098843 no 1537 0.454532609881929 2197 4398905
SGTC_2214 7179297 48.276 µM 0.114042482257259 0.463003506227365 no 1538 0.454602058565347 2165 769744
SGTC_2871 9038510 12.99 µM 0.113628171562983 0.463169900312387 no 1539 0.454766277151133 2213 4945164
SGTC_3050 9093513 49.47 µM 0.113412664274918 0.463256454183182 no 1540 0.454851699926058 2167 25236664
SGTC_3197 9113331 49.47 µM 0.113197280371111 0.463342960237272 no 1541 0.454937075880006 2166 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_1258 0671-0043 57.1 µM 0.113047037801378 0.463403304175375 no 1542 0.454996631714889 2084 4298767
SGTC_3198 9112019 49.47 µM 0.112780283188146 0.463510446481864 no 1543 0.455102375167351 2165 45595555
SGTC_310 1273-0058 1.06 µM 0.111260393687041 0.464120962171712 no 1544 0.455704930806475 2188 2734232
SGTC_1072 oxiconazole 14.9 nM 0.111156058025123 0.464162875280351 no 1545 0.455746298120468 2217 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_689 0833-0039 98 µM 0.108314576746487 0.465304489779182 no 1546 0.456873080036208 2191 5374726
SGTC_1046 2001-0062 216 µM 0.107626301881688 0.465581059497966 no 1547 0.457146066144999 2127 739778
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.107598961511925 0.465592046032081 no 1548 0.457156910401481 2233 229346 A bile salt which induces apoptosis.
SGTC_1600 coumarin 106 71.1 µM 0.106753960974451 0.465931616408214 no 1549 0.457492086246256 2163 100336 A hepatotoxic, DNA x-linker.
SGTC_1449 4112-4002 201 µM 0.106481557738584 0.46604108917512 no 1550 0.457600143503223 2054 2059539
SGTC_2086 5274770 176.623 µM 0.106431725592672 0.466061115878101 no 1551 0.457619911320681 2117 689278
SGTC_1269 0831-0796 3.05 µM 0.105924857663281 0.466264822464839 no 1552 0.457820985726299 2209 927758
SGTC_2192 5915882 198.485 µM 0.105736317770486 0.466340597554045 no 1553 0.457895782221333 2206 2876149
SGTC_1672 st016598 6.51 µM 0.105373907550655 0.466486255387898 no 1554 0.458039559768627 2069 4665860 YNL267W PIK1
SGTC_1522 st012842 45.6 µM 0.105178809665428 0.466564669869194 no 1555 0.458116962441831 2162 3491067 YOR116C RPO31
SGTC_985 1493-0307 8.71 µM 0.104594103434793 0.466799684974313 no 1556 0.458348946909465 2221 3278274
SGTC_3273 9137859 49.47 µM 0.104412320092105 0.466872752799857 no 1557 0.458421073051439 2259 2377234
SGTC_2891 9063876 19.48 µM 0.103888919769018 0.467083139817485 no 1558 0.458628750134294 2255 6472478
SGTC_1001 4048-4355 44.4 µM 0.103838388852797 0.467103451811138 no 1559 0.45864880061219 2190 21824233
SGTC_2536 dehydroabietamide 32.04 µM 0.102439428856119 0.467665827840963 no 1560 0.459203944284287 2205 3983547
SGTC_3035 9091303 49.47 µM 0.102396330738912 0.467683154133224 no 1561 0.459221048005721 2218 25237002
SGTC_2644 guaiazulene 100 µM 0.102132508508245 0.467789217201205 no 1562 0.459325748932103 2212 3515 A coloring agent.
SGTC_3178 9107506 49.47 µM 0.101964000704641 0.46785696270707 no 1563 0.459392624694361 2184 8897194
SGTC_2059 5238311 157 µM 0.101478189910068 0.468052279328802 no 1564 0.459585435052008 2153 703021
SGTC_2842 9000675 19.48 µM 0.101380689800887 0.468091479451698 no 1565 0.459624132397223 2055 2989072
SGTC_3293 9120939 62.045 µM 0.101147807780908 0.468185111406464 no 1566 0.45971656374787 2184 934087
SGTC_2860 9025725 38.96 µM 0.0998122541983426 0.468722114526946 no 1567 0.460246689596382 2058 40546248
SGTC_2511 berberine 10.47 µM 0.0976907728230057 0.469575242301628 no 1568 0.46108892136498 2176 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_563 tetrahydrosecaminediol 614 µM 0.0956314708815332 0.470403499031648 no 1569 0.461906634796088 2238 334274 A psychoactive constituent of the cannabis plant.
SGTC_336 4111-0029 111 µM 0.0956258124312347 0.470405775053499 no 1570 0.46190888189296 2134 3131175
SGTC_1030 k029-0042 36.7 µM 0.0947737742188995 0.470748504896273 no 1571 0.462247259114245 2102 6080581
SGTC_2008 4012253 172 µM 0.0925344951943937 0.471649350890123 no 1572 0.463136692789456 2195 603940
SGTC_720 r052-1644 49.9 µM 0.0922936220630007 0.471746261157466 no 1573 0.463232377799795 2181 1422863 YOR257W CDC31
SGTC_1745 st081495 74 µM 0.0920619903897814 0.471839454895247 no 1574 0.463324393717925 2185 13842402 YBL026W LSM2
SGTC_488 nitrendipine 139 µM 0.092046179139652 0.471845816385076 no 1575 0.463330674824742 2264 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_2330 7979373 200 µM 0.0909883691611328 0.472271431314052 no 1576 0.463750916392259 2134 1863007
SGTC_3119 9125183 49.47 µM 0.0899728251157703 0.472680070139854 no 1577 0.464154404820205 2244 22695334
SGTC_1919 st067113 52.3 µM 0.0895682214829613 0.47284288426261 no 1578 0.464315169228382 2164 1268243
SGTC_3 0833-0587 95.581 µM 0.0892517442967982 0.472970239114128 no 1579 0.464440921710524 2171 5382644
SGTC_1971 st069429 63.5 µM 0.0890071993304602 0.473068649326174 no 1580 0.46453809429669 2258 1246522 YGL099W LSG1
SGTC_2377 9073351 62.6 µM 0.0881557116699391 0.473411319263875 no 1581 0.464876458590774 2112 7337946 YHR072W ERG7
SGTC_1188 1403-0014 4.57 µM 0.0873111735684084 0.473751211880214 no 1582 0.46521208635837 2152 9614867
SGTC_2555 cholic acid 100 µM 0.0871954880811122 0.473797772129315 no 1583 0.465258062844136 2159 6708657 Influences liver metabolism.
SGTC_3210 9128157 49.47 µM 0.0863680885672256 0.474130788233005 no 1584 0.465586906874199 2002 17590849
SGTC_1702 st027038 51 µM 0.085673903961583 0.474410201255995 no 1585 0.465862823728684 2160 5521182
SGTC_605 1315-0399 119 µM 0.0854353639188092 0.4745062178141 no 1586 0.465957639793711 2196 24020461
SGTC_2194 5927483 104.545 µM 0.0829170893391665 0.475519956829503 no 1587 0.466958732752819 2250 760979
SGTC_1217 1183-1422 255 µM 0.0815967129249345 0.476051542081089 no 1588 0.467483707642873 2225 2849664
SGTC_2144 5628481 200 µM 0.0814002217387191 0.476130653353356 no 1589 0.467561836387767 2213 2818399
SGTC_1431 4049-0260 9.09 µM 0.0807900886195678 0.476376311104337 no 1590 0.4678044452196 2236 3854841
SGTC_874 0599-0792 117 µM 0.0800046496826673 0.476692565400643 no 1591 0.468116778957719 2266 765305
SGTC_3006 9075424 71.4286 µM 0.0786363158882666 0.47724355526295 no 1592 0.468660950531414 2190 7465181
SGTC_1218 1348-1416 30.7 µM 0.0785869520515512 0.47726343352284 no 1593 0.468680583096628 2250 6787668
SGTC_1914 st062367 72.6 µM 0.0784984880105007 0.477299057135204 no 1594 0.468715766453008 2205 978205
SGTC_824 1304-0008 100 µM 0.0776442600520563 0.477643055749821 no 1595 0.4690555170993 2204 768245
SGTC_1553 gossypol 38.6 µM 0.0773710274639233 0.47775309036656 no 1596 0.469164194204687 2256 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2675 theaflavin digallate 100 µM 0.077343179754305 0.477764305127345 no 1597 0.469175270642461 2252 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1353 1498-1206 8.11 µM 0.0771841750580637 0.477828339442623 no 1598 0.469238515281499 2248 6756808
SGTC_777 1315-0167 517 µM 0.0763615319394689 0.47815964309455 no 1599 0.469565736638668 2090 4221767
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.0761755444928122 0.478234548052136 no 1600 0.469639719406632 2265 6708784 An antioxidant flavonoid
SGTC_1783 st039459 87.517 µM 0.073727858576923 0.479220404633571 no 1601 0.470613465585321 2266 729761
SGTC_1772 st048439 82.2 µM 0.0724827688350439 0.479721939674756 no 1602 0.471108858937185 2145 2927068 YDL195W SEC31
SGTC_594 1487-1584 10.8 µM 0.068049443565804 0.481507984188236 no 1603 0.472873137598995 2251 5013332
SGTC_2565 isoliquiritigenin 100 µM 0.0674718584090237 0.481740702815355 no 1604 0.473103032347549 2066 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_413 propylparaben 100 µM 0.0674111096245853 0.481765179869889 no 1605 0.473127212553499 2194 7175 A pharmaceutical preservative.
SGTC_2661 dactinomycin 12.96 µM 0.0663443897750318 0.482194996459343 no 1606 0.473551821559979 2307 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_645 0845-0943 5.41 µM 0.0663021463526236 0.482212018156003 no 1607 0.473568637222379 2219 1885106
SGTC_343 4130-2827 29.8 µM 0.0661661995736518 0.482266797195962 no 1608 0.473622753307369 2194 1118244
SGTC_665 3914-0008 307 µM 0.0661335581619027 0.482279949931123 no 1609 0.47363574688679 2250 1069549
SGTC_90 0870-0863 4.608 µM 0.0659527140538022 0.482352820739237 no 1610 0.473707736078778 2276 1738164
SGTC_2322 7413319 38.22 µM 0.0651150712454888 0.482690355053648 no 1611 0.474041190390186 2228 1840400
SGTC_2859 9028643 45.46 µM 0.0650858863293123 0.482702115554789 no 1612 0.474052808841177 2257 17151580
SGTC_2435 5706476 10.6 µM 0.0646812419354174 0.482865174648795 no 1613 0.47421389915501 2279 5725375
SGTC_3189 9110682 49.47 µM 0.0645229174534361 0.48292897526793 no 1614 0.47427692982051 2231 17122418
SGTC_2626 ethyl orsellinate 100 µM 0.0643317966780804 0.483005992516439 no 1615 0.474353017897956 2260 75653 A natural product.
SGTC_840 0245-0196 390 µM 0.0642666945964037 0.483032227293345 no 1616 0.474378936237157 2256 3827528
SGTC_491 tetrandrine 80.3 µM 0.0639197101378938 0.483172056007311 no 1617 0.474517078975069 2271 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_2012 4023501 200 µM 0.0625798288707016 0.483712024174823 no 1618 0.475050546079045 2217 3477460
SGTC_3072 9116419 49.47 µM 0.0617508119881188 0.484046130536936 no 1619 0.475380637514977 2249 17170162
SGTC_1248 0469-0687 58.6 µM 0.0613086434668869 0.484224335744841 no 1620 0.475556703631077 2240 4017482
SGTC_1835 st008666 49.2 µM 0.0607813782349112 0.484436841216907 no 1621 0.475766660456634 2187 690455
SGTC_1946 st076057 65.1 µM 0.0604827049473164 0.484557218477231 no 1622 0.475885595041292 2304 953009
SGTC_1022 4477-0945 21.3 µM 0.0590818326215352 0.485121844560616 no 1623 0.476443464414563 2285 4648966
SGTC_552 k242-0005 476 µM 0.0579504793570623 0.485577861949568 no 1624 0.476894036969241 2240 4088318
SGTC_1998 st075797 76.8 µM 0.0573712045680514 0.485811359025617 no 1625 0.477124750317639 2307 24208315
SGTC_2106 5357045 167.29 µM 0.0569253812759423 0.485991067099452 no 1626 0.477302317878723 2278 668842
SGTC_1440 4100-1550 40 µM 0.0568734126259484 0.486012015463995 no 1627 0.477323016836458 2285 742806
SGTC_1318 1280-3875 124 µM 0.0554451065887849 0.486587775087985 no 1628 0.477891930610128 2265 373245
SGTC_2726 cimetidine 79.27 µM 0.0545578502563299 0.486945448146732 no 1629 0.478245359668424 2313 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_3161 9100388 49.47 µM 0.0516805957173768 0.488105405173837 no 1630 0.479391599474536 2277 25236368
SGTC_389 tpck 16.7 µM 0.0504913594712106 0.488584872352841 no 1631 0.479865417383498 2266 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_2841 9004761 38.96 µM 0.0503431448824039 0.488644629548142 no 1632 0.479924471347161 2262 2991039
SGTC_771 0250-0039 27.3 µM 0.0495277866129447 0.488973370423384 no 1633 0.480249346926059 2216 3005115
SGTC_3079 9117512 49.47 µM 0.0492069318510933 0.489102736573248 no 1634 0.480377193571082 2327 7185044
SGTC_2427 5545055 42.75 µM 0.0490709642027934 0.489157558020458 no 1635 0.480431371365381 2277 5372858
SGTC_282 k297-0036 65.7 µM 0.0490291203792244 0.489174429273324 no 1636 0.480448044566624 2290 5061378
SGTC_139 0099-0334 718.624 µM 0.0484615387447486 0.489403277691088 no 1637 0.480674208021187 2324 97690
SGTC_1109 tnp00067 928.257 nM 0.0481486314435063 0.48952944313743 no 1638 0.480798894417649 2212 676295
SGTC_2657 nystatin 74.44 µM 0.0461253020176618 0.490345282202143 no 1639 0.481605189686504 2289 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3331 9141060 1.957 µM 0.0457154416883842 0.490510549529256 no 1640 0.481768527994795 2298 4906567 YPR165W RHO1
SGTC_454 lyso-paf C-16 6.67 µM 0.0440289154540209 0.491190621648442 no 1641 0.482440677505672 2269 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_404 fumagillin 50 µM 0.0437652017354768 0.491296963508558 no 1642 0.482545782742457 2223 12015870 A methionine aminopeptidase binder.
SGTC_2727 riluzole 51.77 µM 0.0433747425321535 0.491454416284235 no 1643 0.482701405643541 2343 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_2963 9082507 9 µM 0.0430196935159443 0.491597591049253 no 1644 0.482842917614724 2302 16459611
SGTC_1687 st020778 55.3625 µM 0.0428071895269798 0.491683284549537 no 1645 0.482927616415492 2283 4259299
SGTC_1700 st030840 7.9285 µM 0.0424798746317041 0.491815276981724 no 1646 0.483058077491867 2324 5499307
SGTC_2113 5491891 107.031 µM 0.0415083282015288 0.492207066318095 no 1647 0.483445326816462 2302 789979
SGTC_135 0933-0004 26.348 µM 0.0412755851218595 0.492300924266812 no 1648 0.483538098364682 2290 21230617 YGL099W LSG1
SGTC_1249 0481-0015 10.2 µM 0.0411431644560486 0.492354325538445 no 1649 0.483590881729314 2313 4227577
SGTC_1622 st003707 19.4 µM 0.0408543139316072 0.492470810741176 no 1650 0.483706019607719 2265 10140899
SGTC_986 1493-0483 84 µM 0.0406357930822751 0.492558934412967 no 1651 0.483793124479491 2332 40079
SGTC_2461 5755302 26.15 µM 0.0406095417971031 0.492569520885625 no 1652 0.483803588589555 2329 2788904
SGTC_1615 st002656 86.5 µM 0.0393308210983289 0.493085202468338 no 1653 0.484313316968794 2343 1584458
SGTC_1074 carmofur 3.8 µM 0.0385803843824955 0.49338784349483 no 1654 0.484612470821537 2345 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_518 1021-0119 62.6 µM 0.0377479369673761 0.49372356277762 no 1655 0.484944327518878 2181 1097762
SGTC_2768 sulfasalazine 50.2 µM 0.037634114675694 0.493769466734379 no 1656 0.48498970380093 2338 5384001 An antioxidant and salicylic acid derivative.
SGTC_3289 9119912 71.43 µM 0.0376244040025391 0.493773383003765 no 1657 0.484993575057278 2317 17014829
SGTC_855 0428-0020 25 µM 0.0374443591900284 0.493845994348818 no 1658 0.485065351966722 2245 6812414
SGTC_170 4197-0004 226 µM 0.0367622247864322 0.494121098225636 no 1659 0.485337296964405 2303 218692
SGTC_1777 st045864 34.765 µM 0.0352985665424771 0.494711398871408 no 1660 0.485920833176701 2349 4691462
SGTC_2182 6325192 200 µM 0.0349817152712033 0.494839188133472 no 1661 0.486047160524432 2341 736248
SGTC_1448 4255-0083 152 µM 0.0337430304317722 0.495338766981639 no 1662 0.486541032586014 2346 5399660
SGTC_1810 st050138 53 µM 0.0332346576841978 0.495543802951712 no 1663 0.486743730272171 2356 3444541
SGTC_1631 benzylvanillin 81.9 µM 0.0319887374836191 0.49604631008348 no 1664 0.487240516244214 2307 75506
SGTC_597 k018-0003 82.8 µM 0.0316492411597283 0.496183237569454 no 1665 0.487375887135857 2334 6786234
SGTC_1660 st012960 28.1 µM 0.0305829495406397 0.496613302897774 no 1666 0.487801070042519 2311 24207266
SGTC_35 0133-0054 64.071 µM 0.0302172491211942 0.49676080106951 no 1667 0.487946896001714 2327 99677
SGTC_353 1988-1175 58.3 µM 0.02979116863756 0.496932652926221 no 1668 0.488116801024275 2306 2788357
SGTC_2291 7917025 104.35 µM 0.0296726756980894 0.496980445012741 no 1669 0.488164051978496 2330 2964612
SGTC_806 3966-4455 5.86 µM 0.0291712963886343 0.497182668194204 no 1670 0.488363986825606 2241 714982
SGTC_2979 9012552 45.46 µM 0.028992221949988 0.497254895131656 no 1671 0.488435396986514 2362 17100905
SGTC_1664 st014217 9.02 µM 0.02820774910348 0.497571301291697 no 1672 0.488748228396967 2353 3982782
SGTC_1187 1391-0724 117 µM 0.0281774893497586 0.497583506172376 no 1673 0.488760295495559 2294 6997986
SGTC_2665 lovastatin 100 µM 0.0272400874550163 0.497961596178257 no 1674 0.489134121196491 2356 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1265 0819-1001 68.8 µM 0.0269444722982563 0.498080829463383 no 1675 0.489252011307703 2361 3106768
SGTC_3355 9151058 44.0485 µM 0.0251411709068512 0.498808175560599 no 1676 0.489971180457746 2366 17015728
SGTC_2329 6138490 200 µM 0.022973540238466 0.499682475763949 no 1677 0.490835689604176 2295 720019
SGTC_2319 6033012 152.6 µM 0.0225362299923182 0.499858862422913 no 1678 0.491010105988706 2356 847246
SGTC_1092 toremifene 6.32 µM 0.0218363936268426 0.499858862422913 no 1679 0.49128923159277 2368 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2981 9013952 38.96 µM 0.0210842623771173 0.499555494497105 no 1680 0.491589219454617 2323 2996344
SGTC_982 1491-0518 27.5 µM 0.0202053172820363 0.499200977255431 no 1681 0.491939793087424 2351 3091256
SGTC_175 3793-3120 23.7 µM 0.0200963738636947 0.499157035618166 no 1682 0.491983246400003 2358 5322297
SGTC_3151 9099821 49.47 µM 0.0177083957036309 0.498193863265848 no 1683 0.492935741447941 2357 17174189
SGTC_1526 st051518 75 µM 0.0170780078147509 0.497939602757773 no 1684 0.493187191788014 2295 673993
SGTC_693 4161-2696 114 µM 0.016845311985106 0.497845747480641 no 1685 0.493280010639868 2370 805759
SGTC_1145 3546-0597 10.2 µM 0.0166436733817613 0.497764418886863 no 1686 0.49336044152765 2312 875334
SGTC_2720 fluspirilene 36.88 µM 0.0156645907982135 0.49736951865643 no 1687 0.493750987989592 2366 3396 An atypical antipsychotic.
SGTC_2466 5983409 37.09 µM 0.0140051196096145 0.496700198619619 no 1688 0.494412948290106 2306 2879657
SGTC_2587 piperic acid 92.2 µM 0.0137744089412355 0.49660714601063 no 1689 0.494504979652029 2364 5370536
SGTC_2483 5729050 27.16 µM 0.012480511055765 0.496085281320037 no 1690 0.495021125713369 2381 2865180
SGTC_1184 1269-1718 139 µM 0.0124705316798747 0.49608125638749 no 1691 0.495025106598542 2381 5403821
SGTC_1563 conessine 56.1 µM 0.0118657827572314 0.495837346741568 no 1692 0.495266348648837 2382 441082 An anti-amoebic, histamine inhibitor.
SGTC_588 3970-1144 52.9 µM 0.0116335825214865 0.495743695263838 no 1693 0.495358976746078 2376 1888707
SGTC_2656 pseudo-anisatin 100 µM 0.0115949368267608 0.495728108625208 no 1694 0.495374393107859 2383 6708809 A neurotoxin.
SGTC_1620 st003704 16.5 µM 0.0108742617684443 0.495437446117493 no 1695 0.495661882709333 2377 2834414
SGTC_3255 9139072 49.47 µM 0.0103928908317028 0.495243301035759 no 1696 0.495853911069789 2337 17646060
SGTC_2452 5863136 48.41 µM 0.0102008293571811 0.495165839690041 no 1697 0.495930528450495 2383 2184096
SGTC_1170 0310-0127 64.8 µM 0.0101925290868464 0.495162492067482 no 1698 0.495933839607132 2381 774975
SGTC_1651 st011928 86.1 µM 0.0101424223161005 0.495142283268343 no 1699 0.495953828283297 2379 720198
SGTC_776 4476-4378 112 µM 0.00931938031450195 0.494810340121002 no 1700 0.496282158981757 2307 2892008
SGTC_55 0767-0285 6.563 µM 0.00907397227746697 0.494711364671115 no 1701 0.496380058483234 2383 3116166
SGTC_897 1000-0139 31.4 µM 0.0081149680253574 0.494324592100775 no 1702 0.496762631682196 2375 6151020
SGTC_804 1595-0054 20.9 µM 0.00770283909145005 0.494158379474224 no 1703 0.496927042195663 2382 761523 Stimulates phospholipase C.
SGTC_3135 9127742 49.47 µM 0.00752064166863214 0.494084899120918 no 1704 0.496999726345266 2370 3643468
SGTC_1961 st076550 68.7 µM 0.0066001807290101 0.493713679673287 no 1705 0.497366927966071 2395 1579337
SGTC_1393 3470-5649 58.2 µM 0.00595743842284055 0.493454466620222 no 1706 0.497623339988618 2379 4108395
SGTC_2252 omeprazole 400 µM 0.00585410309035084 0.493412792526508 no 1707 0.497664564102873 2382 4594 A proton pump inhibitor.
SGTC_2936 9038235 15.59 µM 0.00545791051596329 0.493253012741431 no 1708 0.497822619542794 2397 4749415
SGTC_882 0843-0131 351 µM 0.00536579072993071 0.493215862074087 no 1709 0.497859369482118 2398 5425421
SGTC_3316 9136639 10.545 µM 0.00530290509203228 0.493190501178199 no 1710 0.497884456864965 2359 4903665
SGTC_1036 k216-0215 33.5 µM 0.0052575299684928 0.493172202044281 no 1711 0.497902558667875 2393 622330
SGTC_2072 5231554 129 µM 0.00516697587169881 0.49313568292402 no 1712 0.497938684035015 2394 789545
SGTC_46 0329-0187a 2.197 µM 0.00441229665465738 0.492831334288269 no 1713 0.498239754022303 2374 46494817
SGTC_1024 4507-0395 26 µM 0.00395164714397786 0.492645564615962 no 1714 0.498423524979952 2360 4201836
SGTC_1029 k015-0030 64.7 µM 0.00285176612456979 0.492202013661278 no 1715 0.498862311461148 2376 2208316
SGTC_2246 7293507 91.5585 µM 0.00138723940066556 0.491611426451819 no 1716 0.499446571727542 2400 887656
SGTC_2906 7926292 26.41 µM 0.00121505839197372 0.491541993667015 no 1717 0.49951526195356 2397 2966319
SGTC_2187 6125751 200 µM 0.00116944650433239 0.49152360050609 no 1718 0.499533458451095 2387 874498
SGTC_355 1311-2252 105 µM 0.000850634629075749 0.49139503895392 no 1719 0.499660645922213 2404 5338538
SGTC_2255 7941087 197.44 µM 0.000720423545886675 0.491342531319987 no 1720 0.49971259261261 2404 935561
SGTC_2101 5377231 179.231 µM 0 0.491052023180123 no 1721 0.5 2405 2844213
SGTC_2525 harmine 47.85 µM -0.000456637784371877 0.490867888124389 no 1722 0.499817827887316 2407 5280953 A monoamine oxidase inhibitor
SGTC_3004 9076122 71.4286 µM -0.00076565235827942 0.490743281894555 no 1723 0.499694548932037 2407 44782551
SGTC_1489 4065-0444 182 µM -0.00136639565227488 0.490501042333598 no 1724 0.499454887172175 2410 2877968
SGTC_1802 st050112 57.9 µM -0.00146407972245676 0.490461653215181 no 1725 0.4994159169055 2399 4662563
SGTC_1019 4262-0212 3.4 µM -0.00166408901288644 0.490381003819422 no 1726 0.499336124840808 2402 4677213
SGTC_1968 st069590 43.6 µM -0.00244062262745482 0.490067887287881 no 1727 0.499026333410034 2412 6384066
SGTC_1846 st056244 14.8 µM -0.0025824996789004 0.490010679795119 no 1728 0.498969732834158 2416 5393182
SGTC_1761 st044296 37 µM -0.00293398086078572 0.489868956866506 no 1729 0.498829512664051 2408 1826700
SGTC_2350 9023895 38.85 µM -0.00442645185557647 0.489267182752006 no 1730 0.498234106969315 2419 2997209
SGTC_34 0469-0683 81.75 µM -0.00504375995446947 0.489018287133476 no 1731 0.497987839433368 2414 3690923
SGTC_949 1165-0505 146 µM -0.00656743153937882 0.488403968680128 no 1732 0.497379992719304 2419 6244267
SGTC_960 1222-0186 7.7 µM -0.00683353708428974 0.488296682233774 no 1733 0.497273834349799 2427 3126296
SGTC_2277 7947813 106.88 µM -0.00822348349828503 0.487736307960493 no 1734 0.496719341716517 2428 1246798
SGTC_3186 9110464 49.47 µM -0.00838004461495518 0.487673189885688 no 1735 0.496656885019947 2432 17018021
SGTC_1028 k015-0029 4.8 µM -0.0119436626611982 0.486236593381644 no 1736 0.495235281263909 2421 4588309
SGTC_1990 st072050 59.8 µM -0.0122460165258954 0.486114713836429 no 1737 0.49511466834636 2421 17233948
SGTC_2147 5545932 89.7195 µM -0.0137337627828073 0.48551501897325 no 1738 0.494521193589454 2434 797404
SGTC_2819 7996655 46.38 µM -0.0145038837547493 0.485204604093803 no 1739 0.49421399040096 2434 6456960
SGTC_103 0844-0104 51.839 µM -0.0147224270924517 0.485116516825831 no 1740 0.494126813532184 2451 5375804
SGTC_330 1488-0319 80.1 µM -0.0148096523140509 0.485081359555495 no 1741 0.494092019496763 2455 6846614
SGTC_742 0kpi-0133 140 µM -0.0148402954345392 0.485069008471125 no 1742 0.49407979600371 2437 2728852
SGTC_1123 mangostin 811.285 nM -0.0154924576477444 0.48480614993301 no 1743 0.493819650848673 2462 5281650 An antioxidant.
SGTC_2832 7992762 51.95 µM -0.015637765631899 0.484747583429808 no 1744 0.493761688371953 2438 2985177
SGTC_1179 1021-1431 9.29 µM -0.0167801138618054 0.484287170592558 no 1745 0.493306017251982 2452 2840958
SGTC_179 1273-0063 6.77 µM -0.0174180765111141 0.484030054753 no 1746 0.493051544186187 2439 3108139
SGTC_2817 7995342 71.43 µM -0.0187371867346773 0.483498439586377 no 1747 0.49252538136587 2448 18879975
SGTC_2854 9024559 71.43 µM -0.0187678953862762 0.4834860640255 no 1748 0.492513132540261 2452 3163529
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.0192374202204537 0.483296847898827 no 1749 0.492325853050387 2460 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_1911 st060208 74.3 µM -0.0193151262678735 0.483265533117516 no 1750 0.492294858581552 2454 688783
SGTC_375 3970-0961 9.27 µM -0.0198868539276023 0.483035135617886 no 1751 0.492066816059357 2451 2898222
SGTC_121 0557-0495 61.343 µM -0.0205428604897523 0.482770781993831 no 1752 0.491805160777114 2456 3104427
SGTC_2477 5967686 25.23 µM -0.0208866734901795 0.482632237292856 no 1753 0.491668028660327 2443 776118
SGTC_2715 st079500 56.4 µM -0.0212229014541467 0.482496751126418 no 1754 0.491533922838402 2440 28246688
SGTC_1943 st076331 65.2 µM -0.0217522849551368 0.482283435253431 no 1755 0.491322778129917 2442 24208415
SGTC_1260 0700-1617 7.75 µM -0.0218651168411597 0.482237970129947 no 1756 0.491277775423383 2465 2853078
SGTC_29 0299-0004 12.984 µM -0.0222218166431292 0.482094241000166 no 1757 0.491135507360971 2450 16871 A napthoquinone isolated from Swertia calycina.
SGTC_744 1594-0068 283 µM -0.0242363774060605 0.48128253522767 no 1758 0.490332030835609 2452 668392
SGTC_1412 3909-8563 178 µM -0.0258400243217475 0.480636449951695 no 1759 0.489692468852421 2447 23767530
SGTC_236 1509-0011 5.31 µM -0.0259081061615536 0.480609021913685 no 1760 0.489665317218086 2449 3107280
SGTC_3187 9109394 49.47 µM -0.0261904344377836 0.480495281686988 no 1761 0.489552722739907 2486 17098090
SGTC_545 4218-0007 221 µM -0.0277623736798158 0.479862031420977 no 1762 0.48892583792037 2484 2840508
SGTC_2949 9072542 2.23 µM -0.0279948935309748 0.479768365882506 no 1763 0.488833111962073 2482 16457352
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM -0.0282033877978526 0.479684379475205 no 1764 0.488749967614221 2438 4620898
SGTC_309 k408-0051 1.48 µM -0.0285595901214875 0.479540894868242 no 1765 0.48860792066926 2475 3640463
SGTC_2035 5154463 94.595 µM -0.0299456060851103 0.478982608479349 no 1766 0.488055216873202 2459 2769623
SGTC_3176 9106582 49.47 µM -0.0302684448900601 0.47885257508518 no 1767 0.487926481183074 2451 17018027
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.0309959296908939 0.478559566172129 no 1768 0.487636392875408 2493 6710655
SGTC_1642 st009582 77.7 µM -0.0315185953605145 0.478349059365182 no 1769 0.487427981279305 2463 6739311
SGTC_371 0195-0006 7.36 µM -0.0341664285249565 0.477282722329012 no 1770 0.486372218529376 2442 3928593
SGTC_1952 st077036 64.1 µM -0.0346344587245059 0.477094253609272 no 1771 0.486185611942878 2461 2937007
SGTC_3339 9145883 14.936 µM -0.0348421558009015 0.477010618760192 no 1772 0.486102802777794 2485 2030670
SGTC_1125 tnp00248 1.32998 µM -0.0349929032427257 0.476949916856781 no 1773 0.486042699900547 2485 24207736
SGTC_2588 indole-3-carbinol 100 µM -0.0351315326032111 0.47689409504787 no 1774 0.485987428771865 2498 3712 Induces cell cycle arrest.
SGTC_566 0958-0068 16.5 µM -0.0356123622674594 0.476700483149937 no 1775 0.485795725455657 2480 6815365
SGTC_1583 clindamycin 39.6 µM -0.0374713107614682 0.475952007131511 no 1776 0.485054607385801 2481 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_3071 9117417 49.47 µM -0.0382793874975982 0.475626674199322 no 1777 0.484732462566744 2496 45595590 YGL055W OLE1
SGTC_723 4182-0001 115 µM -0.0383589773397868 0.475594632082373 no 1778 0.484700734116556 2480 744821 YLR208W SEC13
SGTC_2630 antimycin a 100 µM -0.0384501245914772 0.475557937255663 no 1779 0.484664398429935 2455 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2739 tacrine 100.86 µM -0.0388589340656722 0.475393357855843 no 1780 0.484501428845022 2517 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_147 4466-0538 29.23 µM -0.040406368690131 0.474770426545085 no 1781 0.483884576458491 2594 6742687 YHR072W ERG7
SGTC_2215 7188065 200 µM -0.0415381041049597 0.474314877001186 no 1782 0.483433458185871 2494 940217
SGTC_590 k048-0076 22.4 µM -0.0424473615202335 0.473948904271038 no 1783 0.483071036657714 2497 6832814
SGTC_2709 st078560 56 µM -0.0428438209259236 0.473789337698352 no 1784 0.482913015996563 2494 17250903
SGTC_2773 thioridazine 9.09 µM -0.0430071514017514 0.473723601838504 no 1785 0.482847916567804 2478 5452 An antipsychotic.
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM -0.0454157322981532 0.472754300719834 no 1786 0.481887970682751 2489 2724278 An inhibitor of dopamine biosynthesis.
SGTC_711 k292-0785 179 µM -0.0461338273233836 0.472465343953642 no 1787 0.481601792198342 2487 4146315
SGTC_263 alizarin 107.927 µM -0.0465570654076563 0.472295042479581 no 1788 0.481433125869646 2471 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_2655 perillic acid 100 µM -0.0466732702402235 0.472248285156698 no 1789 0.481386817189892 2487 5702197 An apoptosis inducer.
SGTC_3130 9127414 49.47 µM -0.0469657203639437 0.472130613733489 no 1790 0.481270274275902 2473 1494646
SGTC_1114 scopoletin 1.73284 µM -0.0472480198026388 0.472017028888482 no 1791 0.481157777981573 2486 5280460 A coumarin with genotoxic properties.
SGTC_522 1273-0010 11.6 µM -0.0475972336476845 0.471876523787107 no 1792 0.481018618380996 2692 5705015
SGTC_3172 9105863 49.47 µM -0.0478859323518056 0.471760369405932 no 1793 0.48090357544307 2479 2348785
SGTC_475 α-linolenic acid 10 µM -0.049065260404289 0.471285906286033 no 1794 0.480433644114091 2576 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1647 st011722 22.4 µM -0.0493495800604178 0.471171525871828 no 1795 0.480320354223936 2528 2854783
SGTC_1015 4130-4525 82 µM -0.0506926013860096 0.470631267231289 no 1796 0.479785236154791 2512 1363237
SGTC_2413 inermin 26.06 µM -0.0519146554653327 0.470139717156712 no 1797 0.479298348325232 2590 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_1064 honokiol 6.76 µM -0.0522646932451773 0.469998928875957 no 1798 0.47915889277897 2544 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2838 9002687 71.43 µM -0.0532929369976501 0.469585381929532 no 1799 0.478749253832889 2498 6457060
SGTC_1037 k284-1091 78.7 µM -0.0536432582155181 0.46944449452979 no 1800 0.478609695517985 2486 3334711
SGTC_835 0312-0010 67.2 µM -0.0537671544670413 0.469394668543421 no 1801 0.478560339294073 2500 1626196
SGTC_1865 st057639 52.2 µM -0.0542866726433868 0.46918574488674 no 1802 0.478353383792902 2496 688818
SGTC_630 4356-0227 183 µM -0.0563716601271855 0.468347355421081 no 1803 0.477522866493342 2500 779312
SGTC_2857 9024691 58.44 µM -0.056933600281755 0.468121418830999 no 1804 0.477299044278917 2573 16478292
SGTC_370 0180-0345 38.7 µM -0.0590595553576163 0.46726673975608 no 1805 0.476452336265039 2487 3989527
SGTC_528 3492-0019 172 µM -0.0597016536896096 0.467008632083475 no 1806 0.476196627316318 2505 2869262
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM -0.0597754852476673 0.466978954507638 no 1807 0.476167225296467 2595 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1220 1838-0075 193 µM -0.0597861730492149 0.466974658418993 no 1808 0.476162969092643 2540 5529645
SGTC_2691 st077356 60.2 µM -0.0602866804061062 0.466773477865537 no 1809 0.47596365507326 2595 2839272
SGTC_2822 7994718 71.43 µM -0.0609361571334333 0.466512431252857 no 1810 0.47570502685466 2504 1018011
SGTC_2280 7785178 200 µM -0.0613096181144207 0.466362331198499 no 1811 0.475556315533046 2536 2954328
SGTC_2199 6590217 200 µM -0.0620331239531957 0.466071556042491 no 1812 0.475268226843574 2536 703109
SGTC_1479 0549-0158 134 µM -0.0623466826410192 0.465945543219723 no 1813 0.475143376693942 2537 5440202
SGTC_132 0417-1715 25.805 µM -0.0631052830867499 0.465640691364241 no 1814 0.474841333695776 2532 6769098
SGTC_2470 5664817 21.68 µM -0.0631289070020046 0.465631198159254 no 1815 0.474831927871135 2513 2859561
SGTC_2237 6667747 47.222 µM -0.0635941616049737 0.465444240876538 no 1816 0.474646690349037 2576 729940 YDL015C TSC13
SGTC_1658 st012944 20 µM -0.0642251843698749 0.465190683733858 no 1817 0.474395462280412 2559 24207260
SGTC_2708 st078559 56 µM -0.0645135855697623 0.465074803257152 no 1818 0.474280644963076 2522 17250902
SGTC_950 1165-0508 94.1 µM -0.0651458681594178 0.46482076057334 no 1819 0.474028930230375 2567 6148369
SGTC_2601 securinine 100 µM -0.065522695319047 0.464669363275718 no 1820 0.47387891845455 2554 442872 A GABA receptor antagonist.
SGTC_2095 5432005 200 µM -0.0659371620792643 0.46450284947824 no 1821 0.473713926943105 2544 783734
SGTC_303 1348-1668 34.2 µM -0.0661712762109829 0.464408795867964 no 1822 0.473620732450901 2555 5380509
SGTC_1973 st070275 50.2 µM -0.06634586223436 0.464338658526456 no 1823 0.473551235425105 2492 17118334
SGTC_2203 7227154 166.4 µM -0.0663740926516252 0.464327317479689 no 1824 0.473539997888395 2532 896304
SGTC_2325 6158266 200 µM -0.0668630793735977 0.464130880736298 no 1825 0.473345352812882 2581 3623240
SGTC_428 3448-4153 16.5 µM -0.0678066101871218 0.463751868366814 no 1826 0.472969790853641 2501 3834874
SGTC_2135 5326629 150.42 µM -0.0697754797271077 0.462961088070643 no 1827 0.4721861819711 2555 5020077
SGTC_592 k241-0073 46.5 µM -0.0698864676573392 0.462916515007332 no 1828 0.472142012018937 2548 4230158
SGTC_401 neomycin 50 µM -0.0711130378447456 0.462423952117498 no 1829 0.471653895871449 2561 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_2335 9018011 154.17 µM -0.071346513330545 0.462330200138887 no 1830 0.471560988619022 2622 6458208
SGTC_1679 SEC14.276 6.7 µM -0.0726689883034437 0.461799200546007 no 1831 0.47103476351496 2609 1005053 YMR079W SEC14
SGTC_1757 st041620 31.8375 µM -0.0740689178854217 0.461237175613686 no 1832 0.470477773618982 2582 5289815
SGTC_257 daunorubicin 18.5 µM -0.0750280138747923 0.460852175248508 no 1833 0.470096211427834 2664 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2013 4024628 200 µM -0.0750421319851464 0.460846508229017 no 1834 0.470090594950092 2635 5230760
SGTC_87 0100-0052 35.5 µM -0.078754595658304 0.459356602106573 no 1835 0.468613909617605 2567 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_646 4092-0839 27.3 µM -0.0787716462687822 0.459349760563259 no 1836 0.468607128474683 2604 877796
SGTC_825 1988-2224 89.6 µM -0.0789211127159399 0.459289787790817 no 1837 0.468547685049437 2543 1180859
SGTC_678 1218-2179 85.9 µM -0.0791711852753114 0.459189449318619 no 1838 0.468448231725235 2543 6820081 YOR116C RPO31
SGTC_1736 st036774 51 µM -0.0810123250959306 0.458450795541871 no 1839 0.467716075357425 2605 1272247
SGTC_2902 5787006 60.46 µM -0.0820029181612647 0.458053434992568 no 1840 0.467322196458212 2564 591003
SGTC_687 k029-0044 34.9 µM -0.0830146077917411 0.457647655164532 no 1841 0.466919962184215 2561 5829338
SGTC_1311 1190-0148 100 µM -0.0835089797655823 0.457449382936462 no 1842 0.466723418756936 2638 1961333
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.0840526801975803 0.457231339325899 no 1843 0.466507273588177 2538 4174840
SGTC_1245 0418-0076 17.2 µM -0.084671010158879 0.45698338221421 no 1844 0.466261471861102 2669 6790114
SGTC_929 2805-0021 398 µM -0.084924954735423 0.456881552493091 no 1845 0.466160526220929 2656 3098024
SGTC_1978 st071761 42 µM -0.085261995572145 0.45674640621736 no 1846 0.466026552306499 2588 5147680
SGTC_191 3914-0123 66.505 µM -0.0852880954671916 0.456735940917747 no 1847 0.466016177744552 2554 3144412
SGTC_220 paclitaxel 373.376 µM -0.0853555958253201 0.456708875374453 no 1848 0.465989346837764 2646 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_638 3970-0837 4.09 µM -0.0860659112205977 0.456424073203162 no 1849 0.465707010973751 2590 4118451 YLR208W SEC13
SGTC_3164 9100705 49.47 µM -0.0880056604796975 0.455646441879353 no 1850 0.464936088594546 2678 17174235
SGTC_3014 9081533 49.47 µM -0.0887312222875472 0.455355612943705 no 1851 0.46464775929837 2604 21367265
SGTC_539 4859-0462 2.54 µM -0.0900580387457678 0.454823843437834 no 1852 0.464120546949988 2670 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2612 dictamnine 15.46 µM -0.0904389241979672 0.454671204780485 no 1853 0.463969213187359 2659 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1513 0337-0559 19 µM -0.0927658779606028 0.453738831489837 no 1854 0.463044779762399 2588 775073
SGTC_1957 st077035 62.4 µM -0.0947052137858382 0.452961965058314 no 1855 0.4622744882964 2590 705593
SGTC_1681 tripelennamine 100 µM -0.0968850066658075 0.452088990438171 no 1856 0.461408857867385 2567 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_928 2764-0428 58.7 µM -0.096932255348433 0.452070070592825 no 1857 0.461390096673191 2702 662578
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.0973387904075317 0.451907285784557 no 1858 0.461228675977035 2751 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_2269 7935389 174.42 µM -0.0976619194462727 0.45177790418903 no 1859 0.461100377417137 2566 97605
SGTC_3302 9125395 16.351 µM -0.0979868853295568 0.451647792282163 no 1860 0.460971353620437 2617 17599668
SGTC_181 1447-1644 8.07 µM -0.0987939724246835 0.451324668116366 no 1861 0.460650927194841 2586 534600
SGTC_2499 avocadenofuran 51.48 µM -0.0990115050696422 0.451237582584959 no 1862 0.460564567634035 2584 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_556 4058-0063 51.5 µM -0.0995248283456368 0.451032091565913 no 1863 0.46036078779599 2593 6615692
SGTC_317 4495-0002 170 µM -0.100341468979929 0.450705205118996 no 1864 0.460036618058366 2614 15991618
SGTC_1529 apigenin 74 µM -0.102162002101648 0.449976599367406 no 1865 0.459314043915694 2677 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_44 0929-0055 61.211 µM -0.102953121674139 0.449660033378524 no 1866 0.459000088327567 2591 1379590
SGTC_2120 5538279 151.968 µM -0.103145444350185 0.449583080415955 no 1867 0.458923768981889 2607 2058197
SGTC_153 4077-0274 519.67 µM -0.104122142506139 0.449192309143028 no 1868 0.458536209592372 2614 3121976
SGTC_1795 st049545 62.3 µM -0.104578947313452 0.449009561075802 no 1869 0.45835496034845 2575 5291882
SGTC_702 1488-0190 94 µM -0.104869528049202 0.448893317777176 no 1870 0.458239669351794 2644 949357
SGTC_700 3453-2283 142 µM -0.105435315975182 0.448666993775743 no 1871 0.458015197064742 2710 565664
SGTC_459 nigericin 15.3 µM -0.106494066266478 0.448243522066306 no 1872 0.457595181535984 2697 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1383 3049-0032 20.7 µM -0.107311581993948 0.447916578031584 no 1873 0.457270898249932 2706 712864
SGTC_2956 9076196 2.52 µM -0.107354035649999 0.447899600766552 no 1874 0.457254058968529 2639 16423868
SGTC_168 3970-0862 530.542 µM -0.10803438870146 0.447627539853534 no 1875 0.45698420680061 2662 3135186
SGTC_512 prima-1 270 µM -0.108057233757927 0.447618404954355 no 1876 0.456975145983861 2749 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1945 st075991 56.6 µM -0.108194465993153 0.44756353140774 no 1877 0.456920717342842 2631 1084980
SGTC_1045 1348-1485 165 µM -0.109999991616898 0.446841669562412 no 1878 0.456204690781885 2580 6810614
SGTC_3280 9140961 49.47 µM -0.111106678512541 0.446399295248911 no 1879 0.455765876423978 2584 4901226
SGTC_3312 9133330 71.43 µM -0.111631405406105 0.446189570221539 no 1880 0.455557834867976 2751 17617324
SGTC_1862 st057513 3.81 µM -0.112651001927531 0.445782096736158 no 1881 0.455153624336381 2627 5393163
SGTC_1749 st037932 54.2 µM -0.112764019109099 0.445736933853021 no 1882 0.455108822468549 2719 594497
SGTC_261 5-fluorouridine 15.376 µM -0.112773598427456 0.44573310588658 no 1883 0.455105025095588 2651 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_3120 9124077 49.47 µM -0.113419849237317 0.44547487098534 no 1884 0.454848851917127 2588 18774327 YGL155W CDC43
SGTC_2050 5263056 171 µM -0.114601674821343 0.445002686049132 no 1885 0.454380426071163 2661 763468 YGL055W OLE1
SGTC_3267 9137951 49.47 µM -0.1147745697848 0.444933614364076 no 1886 0.454311903099258 2586 16643986
SGTC_435 c-PAF 6.7 µM -0.114896344447881 0.444884966285875 no 1887 0.454263641307435 2612 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2814 7977482 42.97 µM -0.115434484135698 0.444669993406045 no 1888 0.454050373627971 2723 6456762
SGTC_1465 k213-0056 144 µM -0.116634442418569 0.444190699815657 no 1889 0.453574871441529 2611 24048857 YMR208W ERG12
SGTC_2539 epi(13)torulosol 80 µM -0.117519171279549 0.443837369029277 no 1890 0.45322432641162 2694 6708597
SGTC_184 1494-0393 24.714 µM -0.117812107880837 0.443720389880777 no 1891 0.453108267830923 2604 3090647
SGTC_1464 k208-0027 110 µM -0.118675657452876 0.443375574917097 no 1892 0.452766161385532 2662 X1464
SGTC_1209 2323-2347 50.3 µM -0.118708348490054 0.443362522240943 no 1893 0.452753211091165 2601 5412760
SGTC_2295 7971645 200 µM -0.1192502475695 0.443146165074217 no 1894 0.452538549412342 2701 2978226 YKL099C UTP11
SGTC_465 cgp-37157 41 µM -0.119270725660714 0.443137989378647 no 1895 0.452530437728042 2611 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_904 1141-0088 396 µM -0.120488518036417 0.442651840262929 no 1896 0.452048087331142 2658 1378119
SGTC_964 1287-0107 19.4 µM -0.121437961802246 0.442272877179553 no 1897 0.451672075096973 2730 51516812 YPR165W RHO1
SGTC_1485 3909-9022 254 µM -0.121595433483621 0.442210028682126 no 1898 0.451609715102649 2622 714516
SGTC_731 3966-0296 387 µM -0.122445024195457 0.441870973802576 no 1899 0.451273291298487 2633 660956
SGTC_2685 mycophenolic acid 18.85 µM -0.122705749718108 0.44176693192208 no 1900 0.45117005533065 2669 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_2566 crystal violet carbinol 226 nM -0.124040028112714 0.441234554440923 no 1901 0.450641790962741 2787 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_3202 9113761 49.47 µM -0.124322310731631 0.441121937165181 no 1902 0.450530041464226 2813 4798415
SGTC_2039 Aminomethylbenzodioxan 200 µM -0.124501008755944 0.441050647653025 no 1903 0.450459300861703 2614 15053
SGTC_735 3076-0345 636 µM -0.124783377715757 0.440938003713664 no 1904 0.450347523594086 2722 2888990
SGTC_1018 4259-0013 28.1 µM -0.124971915799096 0.440862793883997 no 1905 0.450272891974524 2779 6801262
SGTC_385 1494-0393 12.4 µM -0.125523454366267 0.440642791589571 no 1906 0.450054578992468 2668 3090647
SGTC_3053 9095903 49.47 µM -0.125696929427961 0.440573598197161 no 1907 0.449985916275552 2623 17174018
SGTC_3184 9108758 49.47 µM -0.125938281244094 0.440477334059344 no 1908 0.449890389926429 2607 902885
SGTC_591 4299-0174 154 µM -0.127650771923028 0.439794401655771 no 1909 0.449212674789423 2672 5509088
SGTC_2304 7443016 91.4 µM -0.129908061368243 0.438894480285379 no 1910 0.448319583145068 2609 939854
SGTC_996 3970-0799 1.8 µM -0.130227935961674 0.438766980215174 no 1911 0.4481930465388 2707 6615648 YGL040C HEM2
SGTC_2119 5528445 120.635 µM -0.130330611517918 0.438726055708502 no 1912 0.44815243106187 2764 791935
SGTC_519 k048-0011 62.8 µM -0.131035335416006 0.438445183985347 no 1913 0.447873677383436 2767 6836379
SGTC_311 1315-0136 58 µM -0.131481285025013 0.438267464235026 no 1914 0.447697295215794 2775 6759207
SGTC_314 1671-0008 2.74 µM -0.132303293272578 0.43793991031734 no 1915 0.447372201310584 2632 3913060
SGTC_1694 st024011 44.9 µM -0.132812668770518 0.437736955647163 no 1916 0.447170767446704 2664 2787533
SGTC_2093 5331342 194.4 µM -0.133706160706325 0.437380993898792 no 1917 0.44681746668601 2752 33839
SGTC_2954 9074818 52.69 µM -0.135041565332633 0.436849071385474 no 1918 0.446289505461764 2752 16648742
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM -0.135932364929591 0.436494308737924 no 1919 0.445937374710736 2767 5024745
SGTC_218 alverine citrate 93.75 µM -0.136232793741727 0.436374673890711 no 1920 0.445818625587838 2748 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_784 4579-0127 173 µM -0.136498505888709 0.436268868542439 no 1921 0.445713602812217 2860 1948547
SGTC_487 nimodipine 119 µM -0.136586096764077 0.436233991259905 no 1922 0.445678983336818 2629 4497 L-type voltage-gated calcium channels inhibitor
SGTC_1294 1000-1494 117 µM -0.137555179925933 0.435848151025609 no 1923 0.445295989966556 2667 712797 YDL207W GLE1
SGTC_2800 7887935 81.82 µM -0.137628611612933 0.435818916700342 no 1924 0.445266970953229 2783 2961002
SGTC_1590 st077108 57.8 µM -0.138086137979598 0.43563677606546 no 1925 0.445086170555921 2624 5489485
SGTC_782 0083-0095 30.5 µM -0.138645052041461 0.435414291653654 no 1926 0.444865320352099 2632 3591729 An indicator and reagent.
SGTC_1601 4'-hydroxyflavanone 55.5 µM -0.139826184137892 0.434944191032241 no 1927 0.444398662288135 2855 165506
SGTC_291 SEC14.278 35.5 µM -0.140220689406353 0.434787195031119 no 1928 0.444242812807461 2711 1068044
SGTC_2970 9090938 41.86 µM -0.140412720353057 0.434710778754852 no 1929 0.444166954015143 2749 17217104
SGTC_492 tmb-8 126 µM -0.140998934712911 0.43447751729461 no 1930 0.443935391955852 2641 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM -0.142221136663479 0.433991262471983 no 1931 0.44345266842344 2659 16623 A steroid.
SGTC_3125 9127534 49.47 µM -0.143798552908715 0.4333638328492 no 1932 0.442829772805664 2630 1639235
SGTC_2942 9052777 62.25 µM -0.144530096658798 0.43307291250765 no 1933 0.442540946122468 2682 6469503
SGTC_1472 k841-0093 193 µM -0.145646723771707 0.432628922180369 no 1934 0.442100140502693 2770 X1472
SGTC_810 3825-7150 143 µM -0.145657598493302 0.432624598619517 no 1935 0.442095847891716 2717 22330411 YGL099W LSG1
SGTC_1497 4476-2978 41.3 µM -0.145773337651526 0.432578583661536 no 1936 0.442050162253305 2747 1528379
SGTC_2861 9024595 19.48 µM -0.146014325417001 0.432482775964141 no 1937 0.441955039792181 2692 16482810
SGTC_1320 1313-0481 95.3 µM -0.146185361832898 0.432414780707964 no 1938 0.441887530491535 2680 6813365 YLR208W SEC13
SGTC_50 0929-0078 56.389 µM -0.146192813059534 0.432411818530103 no 1939 0.441884589477269 2723 1377751
SGTC_1106 tegaserod maleate 11.7 µM -0.146370226959199 0.432341290120749 no 1940 0.441814564797862 2713 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2439 5492030 7.2 µM -0.147912029787925 0.4317284590296 no 1941 0.441206097120311 2760 5722370
SGTC_1007 4101-0031 70 µM -0.14822258308307 0.431605041080863 no 1942 0.441083554973199 2797 1146276
SGTC_1395 3486-0190 4.35 µM -0.149987097687672 0.430903926936713 no 1943 0.440387397330217 2723 6748079
SGTC_1887 st057648 70.8 µM -0.150257168875889 0.430796635713984 no 1944 0.440280861781451 2827 688672
SGTC_1501 4491-0275 38.4 µM -0.151316423782757 0.43037587472725 no 1945 0.439863057074947 2671 5104718
SGTC_2913 7966556 36.57 µM -0.15167181509739 0.4302347226145 no 1946 0.439722894120695 2677 2976516
SGTC_2605 digitonin 300 nM -0.152153879655542 0.43004327346107 no 1947 0.439532784521467 2674 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_2971 9092186 9.93 µM -0.152253027132541 0.430003899651237 no 1948 0.439493685910973 2661 25236400
SGTC_650 1328-0195 38 µM -0.152778676956751 0.429795163301625 no 1949 0.439286406815887 2661 2780821
SGTC_1782 st039423 80.636 µM -0.152999637482519 0.429707425393323 no 1950 0.439199280585877 2719 2068169
SGTC_2116 5511452 16.8835 µM -0.153163907582785 0.429642200087229 no 1951 0.439134509682725 2796 870744
SGTC_3261 9137475 49.47 µM -0.154786743639606 0.428997938106574 no 1952 0.438494721146764 2658 17027690
SGTC_71 0417-1750 47.813 µM -0.154884184820432 0.428959260195562 no 1953 0.438456310934128 2834 6811472
SGTC_733 4069-0007 56.1 µM -0.15674028831582 0.428222636599001 no 1954 0.43772476700321 2687 5717425 YNL287W SEC21
SGTC_2561 acetosyringone 100 µM -0.159780993096415 0.427016426973993 no 1955 0.436526798509503 2672 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_888 0916-0002 6.97 µM -0.159841292180259 0.426992513940436 no 1956 0.436503047890907 2856 2802138 YIL048W NEO1
SGTC_798 1287-0182 476 µM -0.160442916553611 0.426753940215566 no 1957 0.436266092478215 2706 1649755
SGTC_2933 9026794 32.47 µM -0.160862013569052 0.426587763414981 no 1958 0.436101040691101 2746 17586027
SGTC_1970 st070122 35.8 µM -0.162575132589525 0.425908627767811 no 1959 0.435426483895638 2853 102928
SGTC_1080 nisoldipine 24.4 µM -0.162928694534978 0.425768491691133 no 1960 0.4352872888614 2671 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2648 atorvastatin 78.68 µM -0.164608423866133 0.425102850787651 no 1961 0.434626100192315 2778 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_778 3456-2434 196 µM -0.16547944783845 0.424757766492359 no 1962 0.434283312533522 2877 5539063
SGTC_1739 st037196 92.5 µM -0.165672022922572 0.424681479422932 no 1963 0.434207532115011 2805 612214
SGTC_1921 5740136 50 µM -0.166198870328991 0.424472787488003 no 1964 0.434000224215671 2733 1774243
SGTC_2882 9058044 58.44 µM -0.166336368417447 0.424418325972905 no 1965 0.433946123413123 2784 18076804
SGTC_445 e6 berbamine 66 µM -0.166796845406951 0.424235946500631 no 1966 0.433764950458236 2788 6610268 A calcium/calmodulin antagonist.
SGTC_2718 lomofungin 53.02 µM -0.166817300605497 0.424227845259435 no 1967 0.433756902759134 2832 5351222 A RNA synthesis inhibitor.
SGTC_3066 9117245 49.47 µM -0.167331670119597 0.42402414075739 no 1968 0.433554543137339 2756 17176980
SGTC_1003 4049-0218 100 µM -0.167649924657705 0.423898113351151 no 1969 0.433429346402847 2864 295161
SGTC_63 0099-0242 26.702 µM -0.167884423718201 0.423805257727327 no 1970 0.433337102135938 2775 3898502 YLR359W ADE13
SGTC_1454 4239-0054 42.6 µM -0.167937516885268 0.423784234779731 no 1971 0.433316217523116 2891 1340767
SGTC_3214 9129694 49.47 µM -0.16983739896933 0.423032094337884 no 1972 0.432569007025436 2799 17158655
SGTC_2848 9016370 25.97 µM -0.170127503475259 0.422917270070524 no 1973 0.432454932077563 2737 7894410
SGTC_451 chloral hydrate 100 µM -0.170284462338579 0.422855147992584 no 1974 0.432393215030551 2815 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_2633 5,7-dihydroxyisoflavone 100 µM -0.170556714716056 0.422747398937609 no 1975 0.432286167882888 2844 5377381
SGTC_450 aminopyrene 156 nM -0.172432373155618 0.422005228930966 no 1976 0.431548811613876 2756 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_1636 st007707 68.9 µM -0.17300999490447 0.421776728283211 no 1977 0.431321785649761 2846 403051
SGTC_2810 7959871 45.46 µM -0.173637611637709 0.421528480037157 no 1978 0.431075135591656 2814 2974535
SGTC_2396 5342950 42.78 µM -0.173800421796974 0.421464087009429 no 1979 0.431011156446565 2795 1886677
SGTC_3246 9135460 32.98 µM -0.175169506113665 0.420922683877462 no 1980 0.430473222216829 2797 41446951
SGTC_3228 9131799 49.47 µM -0.175363475523124 0.420845990921882 no 1981 0.430397019070114 2765 17015818
SGTC_2496 diffractaic acid 79.83 µM -0.176250678535088 0.420495240844749 no 1982 0.430048504094195 2990 94870 An apoptosis inducer which activates caspases.
SGTC_2707 st078556 66.6 µM -0.179971971433261 0.41902474203162 no 1983 0.428587286221723 2809 17250899
SGTC_2388 9080168 200 µM -0.180126351248022 0.418963761888152 no 1984 0.428526687820443 2715 15943073
SGTC_3328 9140624 29.0385 µM -0.182671173903566 0.417958836624166 no 1985 0.427528017521207 2906 4904392
SGTC_3324 9138759 60.749 µM -0.182709730175679 0.417943615235239 no 1986 0.427512890352888 2857 45595710
SGTC_1404 3909-7820 48.3 µM -0.182829808912242 0.417896210891316 no 1987 0.427465779342612 2778 23741373
SGTC_2216 7189485 200 µM -0.183253578607303 0.417728925827757 no 1988 0.427299528214629 2829 731273
SGTC_3169 9102970 49.47 µM -0.183606580806041 0.417589587927083 no 1989 0.427161050078631 2713 17027839
SGTC_2645 abamectin 100 µM -0.183902415617999 0.417472823246763 no 1990 0.427045004870981 2813 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_196 k015-0023 18.111 µM -0.184891696152129 0.41708241154326 no 1991 0.426656992106968 2727 5211998
SGTC_1985 st071382 65.5 µM -0.18541963684516 0.416874097371664 no 1992 0.426449953745178 2740 6123237
SGTC_2641 levomentholum 100 µM -0.186067265206657 0.416618588870101 no 1993 0.426196006093316 2744 16666
SGTC_629 3448-6466 76.7 µM -0.187642259319887 0.415997354409668 no 1994 0.425578548229416 2769 573744
SGTC_2990 9074105 71.4286 µM -0.188571129534131 0.415631072776762 no 1995 0.425214481056302 2754 6502001
SGTC_1555 citronellol 128 µM -0.18908549105266 0.415428275974512 no 1996 0.425012906412712 2770 8842 A terpine precursor.
SGTC_1076 itraconazole 331 nM -0.189834198730182 0.415133124018338 no 1997 0.424719528215685 2731 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_2160 5660466 132.927 µM -0.190388492983654 0.414914643633038 no 1998 0.424502357015869 2701 2859134
SGTC_1098 clofazimine 15.1 µM -0.191276747952018 0.414564584332083 no 1999 0.424154388599214 2842 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_2843 9000894 45.46 µM -0.193649456969857 0.413629838379689 no 2000 0.423225185027398 2706 2242070
SGTC_1142 3253-1408 9.78 µM -0.194944314690879 0.413119925777216 no 2001 0.422718270776042 2731 256655
SGTC_2618 avocadyne 43.43 µM -0.196217343683801 0.412618752123002 no 2002 0.422220026811827 2771 3015189
SGTC_530 4358-1714 28 µM -0.196776071989059 0.412398833551002 no 2003 0.422001388396421 2855 1564641
SGTC_1915 st067105 30.6 µM -0.197340545360234 0.412176681615187 no 2004 0.421780526263129 2717 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_188 3229-0966 278.469 µM -0.197704571066864 0.412033431999114 no 2005 0.421638106557912 2789 5722370
SGTC_2429 5902844 64.44 µM -0.199953516829636 0.411148698441257 no 2006 0.420758467549546 2922 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_3088 9117578 49.47 µM -0.200397903780994 0.410973930258551 no 2007 0.420584699389654 2767 678341
SGTC_952 1185-0122 232 µM -0.201028809709361 0.41072583838447 no 2008 0.420338023498573 2716 678600
SGTC_3095 9117207 49.47 µM -0.205120076499656 0.409117895666547 no 2009 0.418739155569997 2901 17015229
SGTC_1332 1480-0653 17.5 µM -0.205693096384027 0.408892809745859 no 2010 0.41851532577055 2782 5749438
SGTC_3145 9085516 49.47 µM -0.206700039599395 0.408497348754446 no 2011 0.418122063236173 2847 25236195
SGTC_2271 7849410 118.62 µM -0.208181475072225 0.407915707902225 no 2012 0.41754363623276 2750 972430
SGTC_3011 9081274 71.4286 µM -0.208941092994273 0.407617545492503 no 2013 0.417247112246872 2802 6625322
SGTC_2362 9071156 126 µM -0.20944223619877 0.407420867903249 no 2014 0.417051512047266 2949 653133
SGTC_2052 5265182 7.135 µM -0.209966038613912 0.407215322471379 no 2015 0.416847089719887 2918 1239884
SGTC_849 0386-0493 241 µM -0.212841083271549 0.406087581906629 no 2016 0.41572545901577 2793 726119
SGTC_2688 kanamycin b 96.69 µM -0.2141523533929 0.40557349225906 no 2017 0.415214125280759 2906 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_284 0988-0104 32.6 µM -0.214158696323503 0.405571005878181 no 2018 0.415211652184098 2880 4666532
SGTC_3258 9138477 49.47 µM -0.215554344527056 0.405024015147187 no 2019 0.414667573445976 2810 4970355
SGTC_2717 st081029 62.2815 µM -0.215901715949403 0.404887900065983 no 2020 0.414532179755617 2877 5292846
SGTC_2801 7907800 81.82 µM -0.216553775032711 0.404632426324025 no 2021 0.41427805650008 2881 6620925
SGTC_1787 fluconazole 80 µM -0.217181814290414 0.404386401868826 no 2022 0.414033328275419 2826 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_1226 3909-7979 35.4 µM -0.217442602018631 0.40428425349968 no 2023 0.413931716854367 2908 6615510
SGTC_2397 5161689 200 µM -0.218617000441249 0.403824332422257 no 2024 0.41347420434388 2994 2259942
SGTC_2175 5807670 165.306 µM -0.218772034887219 0.403763627333871 no 2025 0.413413816057979 2896 241186
SGTC_741 4582-0002 126 µM -0.219172256291675 0.403606927874435 no 2026 0.413257933176539 2789 2912688
SGTC_264 promethazine 12.5 mM -0.222207586073931 0.402419004696924 no 2027 0.412076144451622 2818 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1264 0783-0040 158 µM -0.222447461430706 0.402325164026223 no 2028 0.411982784157137 2756 2855798
SGTC_2600 tangeritin 87.95 µM -0.224451330779 0.401541458792358 no 2029 0.41120306659355 2792 68077 A bioactive flavone.
SGTC_2785 7756463 72.73 µM -0.224664987975229 0.40145792162204 no 2030 0.411119951931463 2814 2201551
SGTC_2569 tetrandrine 100 µM -0.225863907665472 0.400989243341529 no 2031 0.410653634984614 2879 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1991 st073000 8.92 µM -0.225995215029985 0.400937921683021 no 2032 0.41060257095889 3005 4301969 YIL048W NEO1
SGTC_1359 1582-0056 520 nM -0.226961323731594 0.400560369426148 no 2033 0.410226908290534 2913 3661189
SGTC_2531 methyl deoxycholate 70.07 µM -0.228626265401396 0.399909933587294 no 2034 0.40957970417836 2807 16667744 Haematoxylin.
SGTC_3084 9116877 49.47 µM -0.229445425903165 0.39959001733643 no 2035 0.409261366478514 2805 27241325
SGTC_429 1112-0049 25.5 µM -0.23059893832117 0.399139637080455 no 2036 0.408813196240764 2808 2836170
SGTC_1507 4075-3230 155 µM -0.231184901647151 0.398910903475382 no 2037 0.408585579530758 2770 659771
SGTC_768 0384-0033 77.3 µM -0.231391984585553 0.398830075950602 no 2038 0.408505145795996 2825 3965305 YMR134W ERG29
SGTC_3090 9117696 49.47 µM -0.231566381626879 0.398762009578681 no 2039 0.40843741068268 2900 7923821
SGTC_3264 9137442 49.47 µM -0.232020998175433 0.398584589287189 no 2040 0.408260852297744 3051 17015726
SGTC_845 0330-0138 4.51 µM -0.232157661279285 0.398531258747515 no 2041 0.40820778040088 2904 9039800
SGTC_887 0885-0007 9.62 µM -0.232215653928813 0.398508628637717 no 2042 0.408185259981742 2944 5719458
SGTC_1653 st012112 65 µM -0.232533593161078 0.398384567261107 no 2043 0.408061799298509 2987 720429
SGTC_2313 7726885 200 µM -0.233059336125466 0.398179442432868 no 2044 0.407857665267803 2932 726423
SGTC_1470 k295-0292 231 µM -0.233772750309638 0.397901140464395 no 2045 0.407580702779051 2920 5045612
SGTC_1049 3226-0134 66 µM -0.234167372708926 0.397747221070468 no 2046 0.407427521841301 2797 5702385
SGTC_1956 st077085 54 µM -0.236907310142578 0.396678969940441 no 2047 0.406364349368222 2866 24208685
SGTC_2710 st078562 53.7235 µM -0.236948225937454 0.396663023479009 no 2048 0.406348478103017 2789 17250908
SGTC_2941 9056145 11.23 µM -0.237698112795758 0.396370794318913 no 2049 0.406057623748808 2800 2119517
SGTC_745 0469-0705 296 µM -0.238815662588356 0.395935395831967 no 2050 0.405624262302802 3015 3486736
SGTC_86 0417-1630 471.922 µM -0.239115148826 0.395818737733404 no 2051 0.405508147695644 2847 3634867
SGTC_3068 9116768 49.47 µM -0.239568818648387 0.395642038679801 no 2052 0.405332270001099 2930 41904888
SGTC_2306 7482397 179.52 µM -0.239639512672951 0.395614506120257 no 2053 0.405304865221403 2985 891448
SGTC_1958 st076513 41.9 µM -0.240128899047642 0.395423923546584 no 2054 0.405115165662623 2811 732122 YGL099W LSG1
SGTC_3123 9126162 49.47 µM -0.241674143042737 0.394822320875679 no 2055 0.404516333295649 2813 25239884
SGTC_3286 9117135 37.221 µM -0.242305770730116 0.394576484299045 no 2056 0.404271621297863 2867 3438150
SGTC_2124 5246320 200 µM -0.24267072125414 0.394434460592057 no 2057 0.404130245301704 2927 579342
SGTC_1741 st038134 10.228 µM -0.242730339151461 0.394411261095712 no 2058 0.404107151471005 3065 1272587
SGTC_2733 amorolfine 100 µM -0.243660662127877 0.394049287097215 no 2059 0.403746821131865 2869 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_1975 st070967 30.8 µM -0.244172888653284 0.39385002687372 no 2060 0.40354846169563 2975 261391
SGTC_972 1319-0219 195 µM -0.244281293530927 0.393807860068575 no 2061 0.403506485146218 2929 23903702
SGTC_217 ketoconazole 989 nM -0.245809899280806 0.39321340317241 no 2062 0.402914696811965 2923 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2219 9098279 200 µM -0.247021662178041 0.392742339535411 no 2063 0.402445729739049 2872 902349
SGTC_2262 9014885 67.46 µM -0.247871894603629 0.392411911846036 no 2064 0.402116763134914 2852 6457424
SGTC_2895 9054447 58.44 µM -0.24794720979068 0.39238264567543 no 2065 0.402087625993568 2857 2697450
SGTC_959 1222-0044 107 µM -0.24827098497539 0.392256839209123 no 2066 0.401962373480874 2976 6083612
SGTC_1343 1487-0095 224 µM -0.249996043025321 0.391586738752998 no 2067 0.401295204353781 2926 4560101 YGL055W OLE1
SGTC_1492 4158-0558 28.5 µM -0.250370850296382 0.391441186963654 no 2068 0.401150284981745 2956 3967268
SGTC_285 1486-1325 46 µM -0.250927506946122 0.391225044260554 no 2069 0.400935078580927 2956 22310230
SGTC_816 0325-0417 81.3 µM -0.251658998947737 0.390941066289251 no 2070 0.400652325621198 2908 68101
SGTC_769 0302-0231 76 µM -0.251781492930899 0.390893517664951 no 2071 0.400604981538763 2942 571869 YER009W NTF2
SGTC_21 0849-0113 22.993 µM -0.252181390216807 0.390738300453101 no 2072 0.400450430890049 2869 1560156
SGTC_2890 9046729 58.44 µM -0.252269824752482 0.390703977583309 no 2073 0.400416255180098 2880 903329
SGTC_1021 4476-0760 85.3 µM -0.255112805917387 0.389601025849223 no 2074 0.399317986824174 2875 746768
SGTC_2342 7990637 118.86 µM -0.255160705728796 0.389582450414835 no 2075 0.399299489507963 2969 2033102 YER133W GLC7
SGTC_372 0155-0182 15.9 µM -0.255237385942903 0.389552714533 no 2076 0.399269878626805 2848 771486
SGTC_394 menadione 8.33 µM -0.256720159330389 0.38897783598865 no 2077 0.398697404043305 2988 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1183 1254-0324 198 µM -0.25672957249639 0.388974187232698 no 2078 0.398693770468399 3006 5799357
SGTC_1879 gemcitabine 100 µM -0.256921208678569 0.388899906845402 no 2079 0.398619798921736 2870 60750 A nucleoside analog which inhibits DNA replication.
SGTC_2259 7964009 200 µM -0.2576531378297 0.388616240090432 no 2080 0.398337307884808 3012 313134
SGTC_1936 st074407 74.3 µM -0.257714999321253 0.388592267745635 no 2081 0.398313434629543 2856 809813
SGTC_1394 3474-0001 65.7 µM -0.257951444293397 0.388500645343303 no 2082 0.398222190561334 2902 5017666 YIL048W NEO1
SGTC_3089 9117425 49.47 µM -0.25846064604442 0.388303350788184 no 2083 0.398025708609036 2924 9401657
SGTC_407 eburnamonine 100 µM -0.260561391236936 0.387489704393418 no 2084 0.397215383346908 2839 3195
SGTC_936 3005-4620 401 µM -0.261211005540305 0.387238199997348 no 2085 0.396964895738094 3071 777207
SGTC_1144 3486-0183 12.5 µM -0.261303242331265 0.38720249347526 no 2086 0.39692933319551 2870 6744069
SGTC_1329 1447-1697 50.6 µM -0.262136567225892 0.386879941703879 no 2087 0.39660807781612 2980 2840515
SGTC_2150 5556613 200 µM -0.262218039962705 0.386848410562093 no 2088 0.396576672994248 2903 743190
SGTC_2240 6690706 185.951 µM -0.262247803095873 0.386836891980104 no 2089 0.396565200539765 2790 805876
SGTC_1414 3917-0015 5.4 µM -0.262426338200048 0.386767799491009 no 2090 0.396496384535352 2941 6618702
SGTC_2065 5221596 34.26 µM -0.263156469724283 0.386485278398737 no 2091 0.396214990352241 3000 788581
SGTC_3232 9132874 49.47 µM -0.263660017575325 0.386290467878113 no 2092 0.39602095347109 2874 3784940
SGTC_1116 jasmonic acid 1.58368 µM -0.26526932055513 0.385668059758261 no 2093 0.395400998394514 3030 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_158 k038-0087 26.446 µM -0.265650105692153 0.385520831687391 no 2094 0.39525434641365 2852 X158
SGTC_1980 st071811 45.7 µM -0.266091467959572 0.385350202507013 no 2095 0.39508438289329 3022 4974850
SGTC_1252 0493-0875 34.8 µM -0.266104452975037 0.385345182879221 no 2096 0.395079382815648 2847 3960963
SGTC_1635 st007035 42.4 µM -0.266580510365745 0.385161166260961 no 2097 0.394896081613181 2909 3716403
SGTC_497 capsazepine 133 µM -0.266708822464565 0.385111572548522 no 2098 0.394846680283261 2880 2733484 A calcium channel blocker.
SGTC_1627 st003713 25.6 µM -0.266993561862026 0.3850015250739 no 2099 0.394737059054223 2950 16195070 YER133W GLC7
SGTC_2079 5212404 121 µM -0.267319208279992 0.384875679008103 no 2100 0.39461169933216 2998 758462
SGTC_1478 0453-0656 35.7 µM -0.268115413639023 0.384568036526957 no 2101 0.394305240845108 2924 5258496
SGTC_978 1416-0512 87.4 µM -0.270896872705449 0.383493891719247 no 2102 0.393235175174159 2951 6814003
SGTC_1405 3909-7894 12 µM -0.273696702300185 0.382413556175006 no 2103 0.392158856105009 2987 7104060
SGTC_2799 7812892 81.82 µM -0.274450275480575 0.382122940087462 no 2104 0.391869305686158 3058 20205235
SGTC_2962 9082311 13.18 µM -0.274932706883263 0.38193692488928 no 2105 0.391683969297642 2867 16459453
SGTC_131 0141-0277 33.849 µM -0.275374723686388 0.381766516616666 no 2106 0.391514180623035 3076 1547771
SGTC_3128 9127691 49.47 µM -0.27711187908283 0.3810970230167 no 2107 0.390847100345593 3032 41316314
SGTC_2898 9056270 58.44 µM -0.277658579392012 0.38088640013506 no 2108 0.390637229788884 2879 19154699
SGTC_1407 3909-7909 12.3 µM -0.277886979829523 0.380798416562396 no 2109 0.390549559505361 2903 4411780
SGTC_2681 menadione 3.18 µM -0.278190164841018 0.380681634274545 no 2110 0.390433192160027 2979 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_988 1497-1057 103 µM -0.278448815616207 0.380582014494507 no 2111 0.390333925537353 2915 3533044
SGTC_2139 5578692 56.4705 µM -0.278568628004702 0.380535871235056 no 2112 0.390287945607105 2991 650991 YMR113W FOL3
SGTC_1673 st016611 27.3 µM -0.278655927688711 0.380502250640548 no 2113 0.39025444391631 3092 5226799
SGTC_2417 cerulenin 830 nM -0.278671439056175 0.380496277043296 no 2114 0.390248491436649 2988 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_399 oxolinic acid 75 µM -0.280115097759047 0.379940433210859 no 2115 0.389694600931165 2889 4628 A DNA gyrase inhibitor.
SGTC_1830 st055982 50.3 µM -0.280404151438806 0.379829170243365 no 2116 0.389583726185252 3000 455313 An antimicrobial agent.
SGTC_1484 3473-2379 286 µM -0.280637330869272 0.379739421722452 no 2117 0.389494290142238 2918 671917
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.28079219366017 0.379679820102503 no 2118 0.38943489570446 3114 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_114 0364-0001 490.298 µM -0.280896232529799 0.37963978055169 no 2119 0.389394995186467 2966 4003655
SGTC_1854 st056233 32.9 µM -0.280897755915285 0.379639194283563 no 2120 0.389394410953197 2997 5393174
SGTC_2749 bexarotene 57.39 µM -0.281149457433331 0.379542331874631 no 2121 0.38929788438738 3007 82146 An retinoic acid receptor inhibitor.
SGTC_339 3091-4833 71.4 µM -0.282396717716967 0.379062459785358 no 2122 0.3888196657528 2907 3240077
SGTC_894 0960-0238 55.9 µM -0.282718303806666 0.378938762635733 no 2123 0.388696392017568 2935 6741907 YDL195W SEC31
SGTC_2899 9053889 58.44 µM -0.28347477003853 0.378647839011877 no 2124 0.388406459697936 3014 6470052
SGTC_713 1488-1073 324 µM -0.284674941991179 0.378186415094077 no 2125 0.387946595019406 2885 3312542
SGTC_32 0928-0142 34.1 µM -0.285521976869407 0.377860864468775 no 2126 0.387622134862396 2981 2244242
SGTC_3023 9089636 49.47 µM -0.285633882815921 0.377817860854311 no 2127 0.387579274697192 2986 17249241
SGTC_2815 7968870 71.43 µM -0.287419057248909 0.377132052762963 no 2128 0.386895735469499 2910 2977326 YHR190W ERG9
SGTC_2802 7925815 54.55 µM -0.288253656803855 0.37681155851519 no 2129 0.386576289359157 2896 1262923
SGTC_2488 5268135 45.7 µM -0.289457523699504 0.376349411615954 no 2130 0.386115640203135 3057 1270356 YLR208W SEC13
SGTC_2696 st077691 74.316 µM -0.290677101839811 0.375881414087211 no 2131 0.385649142928385 3073 757133
SGTC_1042 0350-0096 82 µM -0.291037022976355 0.375743333797547 no 2132 0.385511502115226 2898 3122515
SGTC_2592 piperlongumine 83.33 µM -0.291602600376673 0.375526387608156 no 2133 0.38529524349766 3002 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1344 1488-0097 29.1 µM -0.291763484404284 0.375464682327538 no 2134 0.385233733129582 3014 747966
SGTC_1466 k213-0079 57.5 µM -0.292435771421693 0.375206868601734 no 2135 0.384976730655447 2917 3657981
SGTC_1310 1188-0297 994 nM -0.292998014174118 0.374991298278816 no 2136 0.384761834789677 2961 1588352
SGTC_2084 5306078 60.6385 µM -0.293085442166656 0.374957780889486 no 2137 0.384728421949872 2975 679340
SGTC_2358 9037157 4 µM -0.294458664676805 0.374431450749646 no 2138 0.384203722386133 3010 2388925
SGTC_2912 7964298 10.93 µM -0.295791450531773 0.373920842862473 no 2139 0.38369467624767 2995 2975850
SGTC_624 k048-0052 28 µM -0.295946235507314 0.373861557008481 no 2140 0.383635570440541 2975 6835531
SGTC_249 wiskostatin 11.211 µM -0.296489443051615 0.373653520880396 no 2141 0.383428163986069 2954 2775510 A n-wasp and actin depolymerizer.
SGTC_1243 0416-0003 5.65 µM -0.296801480978872 0.373534034096476 no 2142 0.383309037368555 2959 2141977
SGTC_2143 5623677 140.463 µM -0.296822936208274 0.373525818822641 no 2143 0.383300846817874 2932 5375313
SGTC_582 0987-0078 156 µM -0.296962595896643 0.373472344100017 no 2144 0.383247532897099 3022 1625765
SGTC_3076 9116187 49.47 µM -0.29792849154264 0.3731025761235 no 2145 0.382878870870564 3033 27241210
SGTC_1861 st057647 17.4 µM -0.298516685268422 0.37287745870858 no 2146 0.38265442165803 3106 688668
SGTC_1443 4112-3303 14 µM -0.299589381151426 0.372467021211508 no 2147 0.382245192478433 2939 704433
SGTC_431 k089-0097 107 µM -0.301648551630888 0.371679542522497 no 2148 0.381459996040861 3051 5499420
SGTC_455 paf C-16 10 µM -0.301758352159219 0.371637567075071 no 2149 0.381418140912926 2929 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_2173 5763948 167 µM -0.302793882481286 0.371241771172861 no 2150 0.381023472889861 2913 2867177
SGTC_3129 9127257 49.47 µM -0.303062271335596 0.371139210948075 no 2151 0.380921202965829 2951 837894
SGTC_787 4152-0075 138 µM -0.304282334107319 0.370673100214784 no 2152 0.380456401404159 2959 9566539
SGTC_1213 1315-0166 115 µM -0.305514088626132 0.370202715263138 no 2153 0.379987320705115 3053 768401
SGTC_2658 polymyxin b sulfate 77.05 µM -0.305621303155516 0.370161781128576 no 2154 0.37994649926515 2971 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_3111 9122088 49.47 µM -0.306196588073091 0.369942164472653 no 2155 0.379727485027524 2983 16876704
SGTC_954 1189-0853 2.85 µM -0.30762150484945 0.369398381168552 no 2156 0.379185177357526 2924 2828194
SGTC_3021 9087658 49.47 µM -0.309581027962289 0.368651005649409 no 2157 0.378439792729731 3047 25237042
SGTC_223 busulfan 5 mM -0.310977345798289 0.368118743269519 no 2158 0.377908921896305 3036 2478 A DNA alkylator.
SGTC_64 000l-0018 272.079 µM -0.311165747867346 0.368046945640971 no 2159 0.37783731029744 2897 6811119
SGTC_1341 1486-1360 280 µM -0.312334125110669 0.36760179496832 no 2160 0.377393304110213 2933 3976547
SGTC_1927 st060202 13.8 µM -0.312452491525786 0.367556707381392 no 2161 0.377348331587233 2934 688887
SGTC_79 0052-0007 94.094 µM -0.312868075813269 0.367398419398478 no 2162 0.377190446308474 3114 2801472
SGTC_1731 st035964 63 µM -0.313512476975398 0.36715302406981 no 2163 0.376945671452875 2969 6739575
SGTC_1796 st049173 110.4 µM -0.314125937093796 0.366919461854801 no 2164 0.376712695448987 3068 94134
SGTC_918 glabranin 770.725 nM -0.314472803064917 0.366787421623234 no 2165 0.376580984746416 2998 124049 Also referred to as licorice root.
SGTC_3171 9103192 49.47 µM -0.314575827214237 0.366748206822952 no 2166 0.376541867552432 3051 13018434
SGTC_1416 3966-0321 25.3 µM -0.315266130394414 0.366485487806243 no 2167 0.376279799364257 3013 582530 YLR208W SEC13
SGTC_2040 5100729 123 µM -0.315403815398936 0.366433094441135 no 2168 0.376227535150174 2959 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_3268 9137683 49.47 µM -0.315758049280244 0.366298309032783 no 2169 0.376093081009913 2929 1953228
SGTC_516 3992-2719 87.3 µM -0.315889209962629 0.36624840679218 no 2170 0.376043301057635 2894 5350887 YDR037W KRS1
SGTC_2518 prenyletin 46.28 µM -0.317087347894388 0.365792660292396 no 2171 0.375588662418049 3062 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_808 0711-0032 135 µM -0.319038741692103 0.365050796642818 no 2172 0.37484856750545 3084 4252555
SGTC_2870 9038528 12.99 µM -0.319904939915459 0.364721654665286 no 2173 0.374520196498504 3084 6463316
SGTC_3152 9099253 49.47 µM -0.321807581888198 0.363999030289236 no 2174 0.373799235045465 3034 25236131
SGTC_1268 0828-0275 2.46 µM -0.321958595674458 0.363941695848306 no 2175 0.373742030793143 3069 745337
SGTC_3241 9133421 49.47 µM -0.322318263723875 0.363805155241886 no 2176 0.373605799190339 3022 17018221
SGTC_1409 3909-8004 61.9 µM -0.323266638654913 0.363445207084957 no 2177 0.373246658620642 3014 2119279
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.323774352214778 0.363252557957603 no 2178 0.373054437547606 3031 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3233 9132340 49.47 µM -0.324373554317989 0.363025238503917 no 2179 0.372827619434592 2977 17682950
SGTC_679 0422-0091 41.4 µM -0.32440238761292 0.363014301225609 no 2180 0.37281670617548 2979 627384 YHR062C RPP1
SGTC_1760 st045453 10.4495 µM -0.325708090515521 0.362519128666781 no 2181 0.372322611205083 3103 3323419 YIL048W NEO1
SGTC_726 3448-4391 34.2 µM -0.326246640147545 0.362314956931434 no 2182 0.372118878168185 3159 1356692
SGTC_3146 9095609 49.47 µM -0.326896774424211 0.362068534063538 no 2183 0.371872980410074 3029 17173999
SGTC_2207 7258803 200 µM -0.327540314200103 0.361824667027616 no 2184 0.371629628325976 3059 3666799
SGTC_15 0266-0086 27.098 µM -0.328085358646782 0.361618168306904 no 2185 0.371423561982477 3077 1712902 YIL048W NEO1
SGTC_1493 4348-0038 111 µM -0.328243614027936 0.361558218295271 no 2186 0.371363736866919 3045 800424
SGTC_1065 prochlorperazine maleate 2.48 µM -0.329058830050924 0.361249453535864 no 2187 0.371055610874316 3017 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_206 4546-0025 72.014 µM -0.329478115698182 0.361090683404738 no 2188 0.370897166272004 3061 6620745 YIL048W NEO1
SGTC_1690 st023502 41.2 µM -0.330633348914661 0.360653357212377 no 2189 0.370460726430498 3073 24207482
SGTC_893 0958-0369 48.9 µM -0.330933378425112 0.360539807531936 no 2190 0.370347404412292 3113 6819948
SGTC_785 1270-0111 65.3 µM -0.331767411414318 0.360224222613729 no 2191 0.370032446866063 2948 6741994
SGTC_68 0986-0284 82.829 µM -0.332734779969614 0.359858304901564 no 2192 0.369667246704057 3160 423278 YIL048W NEO1
SGTC_644 1498-1197 63.3 µM -0.33323763267354 0.359668146079034 no 2193 0.369477456581651 3089 6741615
SGTC_921 1561-0023 372 µM -0.333980606196457 0.359387246738334 no 2194 0.369197096626188 2964 24050882
SGTC_1986 st071812 45 µM -0.335136120310926 0.358950527330292 no 2195 0.368761203359219 3068 11838594
SGTC_1185 1319-0113 81.3 µM -0.335978780977923 0.358632165111117 no 2196 0.36844343382467 3094 4672763
SGTC_156 3474-0145 5.642 µM -0.336303818803382 0.358509390118953 no 2197 0.368320885242841 3054 2265471
SGTC_729 4092-0585 94.1 µM -0.336679099166787 0.358367655440412 no 2198 0.368179410445156 2976 2169061
SGTC_1143 3454-2408 5.08 µM -0.337555481320734 0.358036742263801 no 2199 0.367849097788826 2990 X1143
SGTC_3162 9099653 49.47 µM -0.338153170348185 0.357811121979315 no 2200 0.367623881938172 3130 25237511
SGTC_2021 4019055 173 µM -0.33920611479532 0.357413769212378 no 2201 0.367227231561358 3167 44827708 YER133W GLC7
SGTC_2922 7999257 32.47 µM -0.339455170363429 0.35731980495817 no 2202 0.367133431561108 3013 2988377
SGTC_3092 9117248 49.47 µM -0.340069745289167 0.35708797374665 no 2203 0.366902002582134 3052 17141857
SGTC_1195 1502-0147 41.1 µM -0.340787530375533 0.356817276177951 no 2204 0.366631769238695 3011 817940
SGTC_1211 1056-0033 32.3 µM -0.341550613256074 0.356529574549705 no 2205 0.366344554565172 3151 6741922
SGTC_2476 5806916 10.51 µM -0.342885819058159 0.356026364478571 no 2206 0.365842180262203 2987 2870194
SGTC_1880 MG-132 525 µM -0.342923187386961 0.356012284769152 no 2207 0.365828123645288 3129 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_2004 4023728 41.89 µM -0.343321688466411 0.355862148996477 no 2208 0.365678233124791 3171 360084 YDR527W RBA50
SGTC_1272 0839-0021 27 µM -0.343388354849717 0.355837034536273 no 2209 0.365653159513286 3090 5027250
SGTC_2764 methyldopa 94.69 µM -0.345218627966053 0.355147781500955 no 2210 0.36496500776687 3196 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_352 k048-0007 5.11 µM -0.345773241323522 0.354939015948941 no 2211 0.364756568241529 3109 6811911
SGTC_65 0798-0905 34.986 µM -0.346734361337793 0.354577337781622 no 2212 0.36439544659542 3401 3602145
SGTC_1058 3448-5425 97.3 µM -0.346838997442697 0.354537970173436 no 2213 0.364356138926839 3016 7279705
SGTC_3106 9121286 49.47 µM -0.34720034673211 0.354402030415526 no 2214 0.364220405184909 3219 15943471
SGTC_1505 k297-0037 20.6 µM -0.347316820673959 0.354358216820289 no 2215 0.364176657671396 3039 4089396
SGTC_647 0140-0236 81 µM -0.349300447352001 0.353612339272203 no 2216 0.363431881319658 3060 990837
SGTC_1634 st006576 41 µM -0.349671308008346 0.353472951562354 no 2217 0.363292694413975 3205 3915356
SGTC_1625 st003711 30.1 µM -0.350651819917008 0.35310452155733 no 2218 0.362924787607703 3225 24207034 YER133W GLC7
SGTC_496 calpeptin 138 µM -0.350974817238464 0.352983184564797 no 2219 0.36280362051781 3070 73364 A calpain inhibitor.
SGTC_3269 9137823 49.47 µM -0.351493099442081 0.352788518204931 no 2220 0.362609224248942 2987 17682936
SGTC_1371 2421-0008 32.7 µM -0.351614922247652 0.352742767253133 no 2221 0.362563536328931 3043 2827552
SGTC_83 0170-0301 39.027 µM -0.351881400648876 0.352642697845553 no 2222 0.362463604197097 2999 3089716
SGTC_2105 5350118 200 µM -0.352012011662206 0.352593653815834 no 2223 0.362414627149784 3045 2133313
SGTC_1155 4088-0394 48.2 µM -0.352041195959889 0.352582695537597 no 2224 0.362403683811274 2993 2326248
SGTC_3223 9129970 49.47 µM -0.354456147805548 0.351676341002803 no 2225 0.361498531193209 2985 17248386
SGTC_2997 9067075 71.4286 µM -0.354518659930062 0.351652890768259 no 2226 0.361475111170284 3118 27209819
SGTC_1655 st012546 55.1 µM -0.354744120661469 0.351568318152918 no 2227 0.361390647140802 3114 720985 YLR208W SEC13
SGTC_1020 4335-0961 93.3 µM -0.35487096989901 0.351520738941821 no 2228 0.361343128762662 2982 669075
SGTC_747 3448-8087 38.7 µM -0.35522021066866 0.351389756084853 no 2229 0.361212312423876 3071 5168703
SGTC_47 0149-0135 24.25 µM -0.355513680211453 0.351279703887185 no 2230 0.361102399055843 3022 5239155
SGTC_1632 st005650 90 µM -0.355589800572001 0.351251160497853 no 2231 0.361073891512655 3138 2759605
SGTC_1976 st070609 63.5 µM -0.356908375497571 0.350756858411055 no 2232 0.360580199667293 2974 682556
SGTC_3027 9089541 49.47 µM -0.357862266634977 0.350399424885567 no 2233 0.360223195000811 3129 9943819
SGTC_254 nsc-64875 3.808 µM -0.358413577315623 0.350192903065048 no 2234 0.360016916217866 3180 56993
SGTC_3108 9121785 49.47 µM -0.360429584236308 0.3494380813221 no 2235 0.359262953104891 3005 17140271
SGTC_1539 benzyladenosine 56 µM -0.360989229917086 0.349228647382464 no 2236 0.359053749139329 3029 92208 A nucleotide analog.
SGTC_2213 7173844 200 µM -0.361499179241535 0.349037851077653 no 2237 0.358863159215048 3064 892728
SGTC_775 4577-0580 57.3 µM -0.361695625649917 0.348964361307834 no 2238 0.358789748141656 3245 2006902
SGTC_373 0844-0104 25.9 µM -0.362200718650594 0.348775434167201 no 2239 0.358601021280639 3177 5375804
SGTC_19 0279-0214 38.434 µM -0.363719961447571 0.348207396254247 no 2240 0.358033567893431 3056 3566274 YBR002C RER2
SGTC_1704 st028805 70.8 µM -0.364018883514861 0.348095670696426 no 2241 0.357921954184738 3114 2876101
SGTC_1154 4088-0362 150 µM -0.364766613931474 0.347816255614033 no 2242 0.357642814333166 3024 6618304
SGTC_84 0443-0269 128.823 µM -0.36562982261234 0.347493790884651 no 2243 0.357320659254272 3168 6150058
SGTC_2151 5563267 85.4165 µM -0.365853355241098 0.347410304847634 no 2244 0.357237251990311 3074 5310824
SGTC_2176 5809774 33.9695 µM -0.365889666846366 0.347396743714114 no 2245 0.357223703598158 3152 2870539
SGTC_1333 1482-0047 286 µM -0.365973080035948 0.347365592501424 no 2246 0.357192581596221 3179 3811116
SGTC_3048 9093155 49.47 µM -0.366712045803075 0.347089665846 no 2247 0.356916910187861 3169 25236002
SGTC_1825 st052143 62.6 µM -0.366984108388907 0.346988099245245 no 2248 0.356815435961061 3207 674173
SGTC_1951 sophoraflavanone G 9.2 µM -0.367276637598345 0.346878904293204 no 2249 0.356706339371637 3055 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1713 st033146 12.748 µM -0.367347471344355 0.346852465469546 no 2250 0.356679924216079 3213 674619
SGTC_2765 myclobutanil 7.74 µM -0.367599131840291 0.346758538766481 no 2251 0.356586081129884 3150 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_2961 9083290 32.55 µM -0.367707135143821 0.346718231814708 no 2252 0.356545809837473 3126 17741490
SGTC_2959 9079155 11 µM -0.368931076386578 0.346261576928294 no 2253 0.356089549579147 3206 16189457
SGTC_2522 biochanin a 4.94 µM -0.369543670075107 0.346033100869108 no 2254 0.355861264492941 3173 5280373 A possible chelator.
SGTC_2505 galangin 7.89 µM -0.369868368046229 0.345912022579528 no 2255 0.355740285656681 2984 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_421 streptovitacin 30 mM -0.370221797379183 0.345780248412567 no 2256 0.355608618349714 3216 91467 include heat shock
SGTC_1819 st053448 58.6 µM -0.37056373765546 0.345652775655356 no 2257 0.355481247596201 3058 2857616
SGTC_94 0334-0113 514.748 µM -0.370632491974204 0.345627146676113 no 2258 0.355455638962772 3074 6795178
SGTC_1954 st077032 68.9 µM -0.371974047737609 0.345127207742402 no 2259 0.354956086022006 3127 698907
SGTC_161 4065-0411 162.148 µM -0.372428281631444 0.344957995895169 no 2260 0.354787000124354 3174 1906281 YLR208W SEC13
SGTC_1270 0831-1170 17.3 µM -0.373507817870893 0.344555969985987 no 2261 0.354385263921302 3076 6764716
SGTC_1905 st060207 84.5 µM -0.374091536203034 0.344338662782182 no 2262 0.354168107720533 3030 1948547
SGTC_473 2-arachidonoylglycerol 10 µM -0.375585136415065 0.343782857971189 no 2263 0.353612671253419 3009 5282280 An endocannabinoid.
SGTC_2117 5521686 200 µM -0.3755992464588 0.343777608889459 no 2264 0.353607425527758 3033 803312
SGTC_1055 3448-0672 86 µM -0.375830148628476 0.343691715181397 no 2265 0.353521586410832 3206 748378
SGTC_391 gliotoxin 8.33 µM -0.377627720573149 0.343023309418168 no 2266 0.352853584442704 3239 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_2047 4141938 200 µM -0.377764102312996 0.342972617499409 no 2267 0.352802921626681 3104 3807862
SGTC_1254 0550-0035 264 µM -0.378517990572882 0.342692454737085 no 2268 0.352522915836665 3198 15121435
SGTC_2372 9071633 200 µM -0.379255245514919 0.342418556965789 no 2269 0.352249165184424 3206 21321366
SGTC_2614 arthonioic acid 13.39 µM -0.380317199301113 0.342024175895556 no 2270 0.351854984921709 3077 6710684
SGTC_1450 4112-4260 37.6 µM -0.380768934509423 0.341856465797144 no 2271 0.351687356268972 3217 1633175
SGTC_2524 avocatin b 10.57 µM -0.380775104087904 0.341854175510585 no 2272 0.35168506707834 3149 6710748
SGTC_770 0389-1121 67.2 µM -0.381124529637058 0.341724470374626 no 2273 0.351555423290119 3252 6753108
SGTC_2676 harmalol 100 µM -0.383079286308015 0.340999218792038 no 2274 0.350830488724487 3168 5459187 A monoamine oxidase inhibitor
SGTC_2642 cholecalciferol 100 µM -0.384815075987097 0.340355700114287 no 2275 0.350187214328818 3168 9821465 A vitamin D precursor, similar to steriods.
SGTC_1189 1431-2119 7.28 µM -0.385165601540136 0.340225804208072 no 2276 0.350057363503982 3122 3107275
SGTC_3329 9141233 27.5565 µM -0.385504362443704 0.340100285997269 no 2277 0.349931887504903 3217 4909101 YNL103W MET4
SGTC_1680 diphenhydramine 100 µM -0.38753812323907 0.339347106748477 no 2278 0.349178933644734 3103 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_81 0411-0046 9.971 µM -0.387743641020215 0.339271031300873 no 2279 0.349102878300035 3142 12925265
SGTC_1134 3477-0009 42.5 µM -0.388606579755671 0.338951673294377 no 2280 0.348783599347303 3307 3973534
SGTC_2829 7992743 58.44 µM -0.389772302185246 0.338520444277331 no 2281 0.348352463387084 3222 16462845
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.390218566609373 0.338355416226193 no 2282 0.348187466782423 3001 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_426 0988-0037 14.6 µM -0.390368712833048 0.338299899309872 no 2283 0.348131959926284 3269 5383008
SGTC_2103 5378138 10 µM -0.391761514025801 0.337785075501084 no 2284 0.347617216959896 3152 244142
SGTC_2228 7354201 200 µM -0.391794669605203 0.337772823832738 no 2285 0.34760496694148 3116 753451
SGTC_2958 9077254 16.72 µM -0.392557887663529 0.337490846610439 no 2286 0.347323024170465 3293 16457351
SGTC_708 3448-5400 146 µM -0.393364371590582 0.337192983584712 no 2287 0.347025190199364 3192 3462195
SGTC_193 1273-0060 1.558 µM -0.393559202051961 0.337121041101642 no 2288 0.346953253602771 3162 2847393 YHR072W ERG7
SGTC_3047 9092122 49.47 µM -0.394050440088243 0.336939674537715 no 2289 0.34677189992436 3152 17173831
SGTC_2907 7721985 69.9 µM -0.395127629555752 0.336542105674267 no 2290 0.346374349509452 3163 3267881
SGTC_1215 3852-0577 11.2 µM -0.395746774810107 0.336313674307289 no 2291 0.346145922650326 3251 2884876
SGTC_1458 k015-0034 6.33 µM -0.397648933204973 0.335612258181473 no 2292 0.345444492541339 3145 3598957
SGTC_975 1335-0046 28.5 µM -0.397722167136351 0.335585264781686 no 2293 0.345417497763736 3129 16486740
SGTC_2597 laccaic acid a 100 µM -0.398489658951803 0.335302424937352 no 2294 0.345134639736098 3203 5491415 A textile dye.
SGTC_3196 9111891 49.47 µM -0.398713919325104 0.335219797019347 no 2295 0.345052005214561 3127 18891510
SGTC_72 0744-0168 198.391 µM -0.39930513127193 0.335002005350132 no 2296 0.344834193339651 3025 677577
SGTC_414 piperonyl butoxide 100 µM -0.402315479758454 0.33389390964862 no 2297 0.343725931865846 3102 5794 A potent inhibitor of cytochrome P450.
SGTC_2917 7979103 53.79 µM -0.402343171635586 0.33388372309506 no 2298 0.343715743299456 3241 2980565
SGTC_966 1300-0360 30.2 µM -0.402554254786356 0.333806079445275 no 2299 0.343638084014477 3104 70588
SGTC_1300 1094-0077 113 µM -0.405544017715923 0.332707107186248 no 2300 0.342538834816587 3123 5532636
SGTC_36 0335-0881 14.2 µM -0.405623411522938 0.332677943269892 no 2301 0.342509662133529 3161 23828853
SGTC_823 0417-1665 178 µM -0.405988893110357 0.332543703108628 no 2302 0.342375380673238 3174 3429856
SGTC_587 k089-0003 57 µM -0.408613990131908 0.331580145644799 no 2303 0.341411481082637 3191 9659696
SGTC_534 k292-0788 63.4 µM -0.408987300253817 0.331443210228833 no 2304 0.341274490528104 3282 4146317
SGTC_286 k060-0067 22.9 µM -0.409978764608234 0.331079636538541 no 2305 0.340910762558523 3147 5985051
SGTC_1420 4'-methoxyflavone 42 µM -0.410344102876071 0.33094570575301 no 2306 0.340776772052495 3213 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_3149 9097855 49.47 µM -0.410495454985512 0.330890227327037 no 2307 0.34072126843263 3246 25236625 YMR079W SEC14
SGTC_1665 st014639 11.4 µM -0.410585907491248 0.330857073548444 no 2308 0.340688099470751 3187 981133 YIL048W NEO1
SGTC_595 3909-8003 73.7 µM -0.414682431216403 0.329356958665028 no 2309 0.339187197637052 3245 699517
SGTC_2220 6782180 200 µM -0.415428339039123 0.329084107520927 no 2310 0.338914182294951 3186 833803
SGTC_1882 5615643 20 µM -0.417460752520575 0.328341118221541 no 2311 0.338170712925226 3216 2253075
SGTC_230 MPP+ 141.667 µM -0.417875974478512 0.328189408914095 no 2312 0.338018899660267 3189 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2886 9058944 51.95 µM -0.418562588379771 0.327938603528096 no 2313 0.337767917993864 3150 4949929
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.418810004747019 0.327848246623605 no 2314 0.337677496231547 3179 6708630 An antioxidant.
SGTC_2011 4012611 177 µM -0.420596319819685 0.32719618042714 no 2315 0.337024940763954 3116 2049887
SGTC_2276 7947513 42.08 µM -0.420929940217989 0.327074455903412 no 2316 0.336903120772921 3191 2105100
SGTC_1533 dihydroergotamine mesylate 29.4 µM -0.421786215286955 0.326762120144481 no 2317 0.336590534097021 3225 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_1596 piperlongumine 63 µM -0.422056302408347 0.326663628059163 no 2318 0.336491961109017 3277 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_214 4373-3496 70 µM -0.423969452551965 0.325966309896399 no 2319 0.335794045740667 3257 3779166
SGTC_2541 muurolladie-3-one 83.07 µM -0.425164009129726 0.325531217951644 no 2320 0.3353585594595 3312 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_690 glyoxal 20.3 µM -0.425435259395523 0.325432453868436 no 2321 0.335259703537223 3216 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_3136 9095672 49.47 µM -0.42571606301465 0.325330224255966 no 2322 0.335157377955942 3171 17217380
SGTC_351 caspofungin 25 nM -0.425833591674236 0.32528744056985 no 2323 0.335114553832324 3172 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_1504 k297-0033 30 µM -0.42591219413605 0.325258828382451 no 2324 0.335085914511549 3089 4388117
SGTC_1624 st003710 6.25 µM -0.426110754351575 0.325186554800645 no 2325 0.335013572069473 3256 24207033
SGTC_2568 diosmetin 100 µM -0.427248669288079 0.324772494050454 no 2326 0.334599107912431 3315 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_374 0880-0231 82.3 µM -0.427614505771755 0.324639420621116 no 2327 0.33446590161315 3202 6833587
SGTC_3100 9120536 49.47 µM -0.43144758233986 0.323246483260622 no 2328 0.333071479224969 3207 16421196
SGTC_3265 9137266 49.47 µM -0.431960283348468 0.323060355267798 no 2329 0.332885139746891 3226 17224265
SGTC_867 0518-0118 155 µM -0.439301286010077 0.320400197128984 no 2330 0.330221621247402 3279 6848158
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM -0.439930305696388 0.320172685473088 no 2331 0.329993792786 3267 17037758
SGTC_2923 7992654 58.14 µM -0.442058612550458 0.319403394674854 no 2332 0.329223396301945 3194 2985126
SGTC_549 1661-1316 519 µM -0.442166546689276 0.31936440182264 no 2333 0.329184345988024 3328 2857282
SGTC_2334 9017922 200 µM -0.4438024749266 0.318773642621434 no 2334 0.328592699451288 3271 3163164
SGTC_2338 7999974 200 µM -0.444992623704476 0.318344150425003 no 2335 0.328162542377344 3194 315925
SGTC_970 1315-0089 19.5 µM -0.448236972801705 0.317174594166403 no 2336 0.32699109100367 3268 6811083 YLR033W RSC58
SGTC_628 1636-0253 16 µM -0.449040563132687 0.316885189017639 no 2337 0.326701197776218 3242 4456143
SGTC_508 roscovitine 141 µM -0.449608129412628 0.316680853086703 no 2338 0.326496512654354 3233 160355 A CDKinase inhibitor.
SGTC_1942 st076330 65.2 µM -0.45003974348434 0.31652550027292 no 2339 0.326340891818367 3327 24208414
SGTC_3219 9131112 49.47 µM -0.452942160539168 0.315481661789109 no 2340 0.325295195492029 3281 17612988 YMR079W SEC14
SGTC_906 1165-0455 526 µM -0.453050269979522 0.315442809179396 no 2341 0.325256271814918 3207 3252859
SGTC_3116 9124943 49.47 µM -0.454363926835475 0.314970867409823 no 2342 0.324783455787514 3216 41905195 YPL160W CDC60
SGTC_705 1124-0212 310 µM -0.454570637756187 0.314896632327041 no 2343 0.324709081334532 3342 9554485
SGTC_213 1246-0773 967 nM -0.45544538816507 0.314582570295812 no 2344 0.324394424102443 3245 6251622
SGTC_832 4083-0019 164 µM -0.457948183533947 0.313684731928648 no 2345 0.323494834360711 3315 1990758
SGTC_2478 5763493 32.33 µM -0.459227731955215 0.313226139619341 no 2346 0.323035318961498 3186 1365576 YLR208W SEC13
SGTC_2876 9059903 25.97 µM -0.459294055684301 0.313202376947218 no 2347 0.32301150793146 3296 6916095
SGTC_1718 roemerine 11.9335 µM -0.459551007862983 0.313110322645103 no 2348 0.322919265805329 3271 235224 An aporphine alkaloid with mutagenic activity.
SGTC_511 blebbistatin 171 µM -0.460045864577171 0.312933070765279 no 2349 0.322741650072541 3358 3476986 A myosin inhibitor.
SGTC_2074 5212007 75.395 µM -0.464081394270396 0.311489208104683 no 2350 0.321294715686137 3310 758611
SGTC_2855 9016525 58.44 µM -0.464879258693306 0.311204084065456 no 2351 0.321008962301869 3232 43811474
SGTC_2635 hydroquinidine 100 µM -0.466954173372041 0.310463125127827 no 2352 0.320266332668118 3219 442912 An experimental heart treatment.
SGTC_2186 6124449 200 µM -0.467589021586056 0.31023657210287 no 2353 0.320039258653929 3313 3834182 YLR033W RSC58
SGTC_1293 1000-1278 195 µM -0.469376041929024 0.309599239733928 no 2354 0.319400435079041 3346 678847
SGTC_618 k072-0232 33.2 µM -0.471120717529071 0.308977561254629 no 2355 0.31877726560329 3297 5872756 YGL099W LSG1
SGTC_1843 st055809 45.5 µM -0.472537879764811 0.308472987594058 no 2356 0.318271455310399 3314 16413835
SGTC_2420 aureobasidin a 50 nM -0.47291470898897 0.308338880204434 no 2357 0.318137015245444 3443 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2735 sertaconazole 140 nM -0.473317588497759 0.308195530228657 no 2358 0.317993307808063 3306 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2178 5812956 200 µM -0.473628716040284 0.308084846857539 no 2359 0.317882347119288 3257 5403383
SGTC_112 phenothiazine 287.218 µM -0.477180354606376 0.306822593013669 no 2360 0.316616849539176 3371 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2687 chenodiol 100 µM -0.477550136688807 0.306691303509692 no 2361 0.316485214065517 3336 5702181 A cholesterol synthesis inhibitor.
SGTC_1888 azatryptophan 97.5 µM -0.478667881821819 0.306294603829014 no 2362 0.316087459170025 3310 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_565 1418-0001 44.5 µM -0.479715650743464 0.305922945525172 no 2363 0.315714798824466 3377 2862145
SGTC_577 r071-0003 38.6 µM -0.480864406765475 0.305515695228342 no 2364 0.315306435579535 3249 4568517 YMR134W ERG29
SGTC_2401 5128683 200 µM -0.483148617025173 0.304706625241165 no 2365 0.3144951080874 3248 708373
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.483310230164385 0.304649417776967 no 2366 0.3144377386577 3296 688788
SGTC_730 1436-0052 41.2 µM -0.483358613698819 0.304632292008777 no 2367 0.314420564342881 3328 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_540 1187-0821 17.3 µM -0.483517523592925 0.304576047497667 no 2368 0.31436416019946 3252 847520
SGTC_2836 9010338 19.48 µM -0.483820205484194 0.304468929158863 no 2369 0.31425673701072 3234 2994051
SGTC_1649 st011737 51.3 µM -0.484360052122478 0.304277920459262 no 2370 0.314065182019629 3296 1761035
SGTC_767 0929-0023 86 µM -0.485895788327743 0.303734837899562 no 2371 0.313520527328414 3368 1204563
SGTC_725 1497-0963 19 µM -0.486188574835951 0.303631348888833 no 2372 0.313416735559979 3356 3549977
SGTC_1441 4106-0040 13 µM -0.487161788419189 0.303287467699943 no 2373 0.313071841037418 3322 2904180
SGTC_1925 st057770 10.1 µM -0.487978356636112 0.302999070924649 no 2374 0.312782585758954 3242 5989122
SGTC_1322 1348-1070 12 µM -0.488536675478918 0.302801953713247 no 2375 0.312584877212632 3354 6758089
SGTC_1369 1866-0067 208 µM -0.490131019548672 0.302239379106159 no 2376 0.312020594568423 3387 3531355
SGTC_481 bay k-8644 50 µM -0.491809636280643 0.301647575765788 no 2377 0.311426961851968 3289 2303 A calcium channel antagonist.
SGTC_2089 5281248 129.67 µM -0.492161247925692 0.301523679655364 no 2378 0.311302678517967 3315 2737878
SGTC_3166 9102297 49.47 µM -0.494372952769275 0.300744874864114 no 2379 0.310521406005979 3309 25237072
SGTC_670 4204-0025 119 µM -0.494611453228639 0.300660946248072 no 2380 0.310437207983753 3341 719039
SGTC_2782 7736369 71.43 µM -0.495530407481373 0.300337663963767 no 2381 0.310112881663924 3283 2950836 YOL077C BRX1
SGTC_173 1273-0061 2.693 µM -0.496373173703575 0.300041322313282 no 2382 0.309815574163475 3330 2847414 YPL266W DIM1
SGTC_1111 tnp00062 510.699 nM -0.497161073390593 0.299764393072692 no 2383 0.30953773471016 3418 676306
SGTC_973 1325-0077 65.9 µM -0.497498550850541 0.299645812658555 no 2384 0.309418762288564 3294 2835149
SGTC_1684 st024538 14.6195 µM -0.498772065506309 0.29919852573403 no 2385 0.308969984516286 3289 6732859
SGTC_789 1309-1135 70.6 µM -0.499695419035946 0.298874412856098 no 2386 0.308644779286616 3366 3092424
SGTC_1093 fluphenazine 7.97 µM -0.502838225461702 0.297772431464506 no 2387 0.3075390079739 3327 6602611 An atypical antipsychotic.
SGTC_2811 7967822 32.47 µM -0.503633241939804 0.297493963980784 no 2388 0.307259564177289 3383 2232244
SGTC_589 1227-0070 34.1 µM -0.503948661911719 0.297383515948748 no 2389 0.307148726828871 3391 2841384
SGTC_1149 3909-7961 23.3 µM -0.504871051660174 0.297060637801355 no 2390 0.306824703782689 3328 735261
SGTC_930 2810-3379 265 µM -0.506705865818051 0.296418846933951 no 2391 0.306180607089904 3455 1015764
SGTC_1643 st009866 20.2 µM -0.506909667564715 0.296347599331424 no 2392 0.306109101037112 3360 3156273 YOR207C RET1
SGTC_1205 4161-2785 76 µM -0.507000332251738 0.296315906142487 no 2393 0.306077292722428 3356 3498106
SGTC_474 dl-dihydrosphingosine 5 µM -0.508949046240717 0.295635080245152 no 2394 0.305393970073174 3421 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2017 5132927 60.65 µM -0.50986359865317 0.295315809441473 no 2395 0.305073512843343 3259 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_879 0831-1030 162 µM -0.50988984932956 0.295306647657331 no 2396 0.305064316866527 3386 1549252
SGTC_1361 1608-0041 5.61 µM -0.510003317422242 0.295267047509256 no 2397 0.305024568832433 3329 X1361
SGTC_3282 9108498 15.4605 µM -0.512859510160012 0.294271047811183 no 2398 0.304024799108215 3357 16459645
SGTC_2705 st078069 42.8 µM -0.512889112930277 0.294260732985623 no 2399 0.304014444730644 3343 1530061
SGTC_2024 5144227 134 µM -0.51369329916564 0.293980585263147 no 2400 0.303733218793166 3395 3475211
SGTC_3345 9148410 3.559 µM -0.514699683340854 0.293630173341852 no 2401 0.303381447375997 3382 4903596
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.515079314647537 0.293498040133322 no 2402 0.303248798394762 3419 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_668 1682-0499 62.6 µM -0.516262907737037 0.293086259541013 no 2403 0.302835399423629 3341 682214
SGTC_2938 9059746 27.26 µM -0.516543568944606 0.292988654796436 no 2404 0.302737408624578 3362 6471769
SGTC_3291 9121177 71.43 µM -0.516574794429058 0.292977796531479 no 2405 0.302726507354064 3315 17015612
SGTC_752 1896-0090 130 µM -0.51693296925555 0.292853259149087 no 2406 0.302601475894139 3388 772567
SGTC_1168 k815-0004 80.5 µM -0.517702336174211 0.292585833399254 no 2407 0.302332984015875 3270 642433
SGTC_335 4077-0256 27.6 µM -0.519522397860111 0.291953646741758 no 2408 0.301698248980219 3372 3121989
SGTC_655 k060-0012 42 µM -0.520188220876563 0.291722536435242 no 2409 0.301466197191002 3297 5994525
SGTC_2839 9003951 25.97 µM -0.520706871863477 0.291542569329278 no 2410 0.301285493283956 3396 2990634
SGTC_1231 0242-0792 125 µM -0.521115176886369 0.291400927687504 no 2411 0.301143269492344 3317 3707635
SGTC_1570 verbenone 133 µM -0.521284347875885 0.291342251418886 no 2412 0.301084351480632 3443 29025 A natural terpanoid with antifungal properties.
SGTC_2205 7238770 200 µM -0.522846453728442 0.290800702060435 no 2413 0.300540554844186 3408 279867
SGTC_672 1441-0018 53.7 µM -0.523071316245984 0.290722785704464 no 2414 0.300462312761085 3292 251141
SGTC_548 1436-0017 110 µM -0.524890793241226 0.290092684243194 no 2415 0.299829554998485 3464 9677137
SGTC_23 0213-0011 39.996 µM -0.52502618902814 0.290045821046661 no 2416 0.299782492663386 3453 627608
SGTC_1766 st045414 44.774 µM -0.525032487862056 0.29004364098034 no 2417 0.299780303327855 3410 253960
SGTC_1228 0124-0032 52.5 µM -0.525800136738159 0.289778010370216 no 2418 0.299513539764806 3414 X1228
SGTC_2673 kobusone 100 µM -0.526566529773587 0.289512928235848 no 2419 0.299247320003443 3423 6710676 An epoxy ketone and protein crosslinker.
SGTC_356 1634-0012 32.5 µM -0.529566052927278 0.288476541494349 no 2420 0.298206418133832 3426 735457
SGTC_1216 1165-0504 9.65 µM -0.53019889398501 0.288258107610538 no 2421 0.29798701890478 3434 6304004
SGTC_290 2043-6722 48.1 µM -0.531166188984933 0.287924383124839 no 2422 0.297651810321428 3411 773758 YLR208W SEC13
SGTC_2674 ligustilide 100 µM -0.532356851439215 0.287513845747391 no 2423 0.297239431918011 3388 5319022 A signalling regulator.
SGTC_2292 7671323 168.05 µM -0.534831304815357 0.286661546978543 no 2424 0.29638325695038 3433 937504
SGTC_3170 9103054 49.47 µM -0.537880735354788 0.285612854512586 no 2425 0.295329694569534 3380 16432970
SGTC_2677 mitomycin C 100 µM -0.539404323228105 0.285089580837861 no 2426 0.294803949316134 3422 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1933 st074711 15.9 µM -0.539476907011047 0.285064663469841 no 2427 0.294778913563729 3403 17250958
SGTC_2268 7933382 153.85 µM -0.5419866386757 0.284203734162788 no 2428 0.293913855201101 3436 935025 YOR257W CDC31
SGTC_1904 st060225 78 µM -0.544541910666985 0.283328462144192 no 2429 0.29303430803553 3429 66595
SGTC_2285 7945142 200 µM -0.545817138766546 0.282892134969712 no 2430 0.292595820491609 3422 2970608
SGTC_1366 1683-0113 21.9 µM -0.54900454630223 0.281802957206287 no 2431 0.291501164931596 3393 708623
SGTC_1559 coumarin 343 70.1 µM -0.549306343407865 0.281699934122356 no 2432 0.29139761741874 3483 108770 A hepatotoxic, DNA x-linker.
SGTC_712 r015-0009 80.6 µM -0.549531434107357 0.28162310777377 no 2433 0.291320399283838 3436 6813872 YLR060W FRS1
SGTC_1786 berberine 21.6 µM -0.550722554626032 0.281216731321042 no 2434 0.290911940372091 3428 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_3257 9139206 32.98 µM -0.551492962220923 0.280954041042974 no 2435 0.290647894911458 3430 4910041
SGTC_2327 6189656 200 µM -0.551585727774751 0.280922418243659 no 2436 0.290616108495554 3443 5349088
SGTC_1814 st052110 31.539 µM -0.55195005082954 0.280798241003699 no 2437 0.290491287765505 3464 674163
SGTC_1445 4239-0156 97.7 µM -0.552347179697911 0.280662912348535 no 2438 0.290355256024392 3501 4008346
SGTC_3229 9132204 49.47 µM -0.553562745446757 0.280248883111006 no 2439 0.289939064015735 3411 17682924
SGTC_1079 idarubicin 2.36 µM -0.553664971696467 0.280214077707359 no 2440 0.289904075992643 3433 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1467 k284-1082 293 µM -0.553824155399044 0.280159883928596 no 2441 0.289849597617168 3450 3334705
SGTC_2293 7624732 200 µM -0.554207153798932 0.280029513689272 no 2442 0.289718541500745 3412 894453
SGTC_854 0422-0053 192 µM -0.556019852683841 0.279412881713791 no 2443 0.289098641620424 3451 3596728
SGTC_2487 5918373 44.05 µM -0.55630343960691 0.279316472675765 no 2444 0.289001718096025 3510 2876279
SGTC_3213 9129884 49.47 µM -0.556812168906489 0.279143564093287 no 2445 0.288827884375742 3394 17190742
SGTC_1426 4048-4480 71.7 µM -0.557846127715547 0.278792299222514 no 2446 0.288474730537607 3461 14224343
SGTC_3243 9134147 49.47 µM -0.55940611444578 0.27826273537433 no 2447 0.28794229468837 3480 24282180
SGTC_1564 D-Arginine 115 µM -0.560718443342313 0.277817623308334 no 2448 0.287494746076879 3394 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_1960 st011366 51.8 µM -0.561512004131069 0.277548634333946 no 2449 0.287224274654019 3459 3972846
SGTC_2211 7117706 200 µM -0.562025908181216 0.27737450700143 no 2450 0.287049183651287 3442 822771
SGTC_1186 1319-0216 26 µM -0.56280442385418 0.277110822472819 no 2451 0.286784033794522 3514 4565136
SGTC_2102 5377816 72.7585 µM -0.563199422400362 0.276977082744177 no 2452 0.28664954808238 3509 1379702
SGTC_1375 2910-0797 186 µM -0.5632914651715 0.276945923181631 no 2453 0.286618214447284 3383 742508
SGTC_2062 5245942 200 µM -0.56454959352795 0.276520176719346 no 2454 0.286190079388242 3513 1376160
SGTC_289 k017-0060 526 µM -0.565507624696562 0.27619619749738 no 2455 0.285864269812004 3388 5512909
SGTC_1611 st001856 99.4 µM -0.569201615450073 0.274948740400454 no 2456 0.284609662245776 3412 647478
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM -0.571510492727045 0.274170447193321 no 2457 0.283826824885541 3481 6708760
SGTC_2939 9044578 71.43 µM -0.572704805584628 0.273768286974068 no 2458 0.283422291555952 3436 2653634
SGTC_3024 9090631 49.47 µM -0.573597707762953 0.273467811299779 no 2459 0.283120031640295 3457 25236383
SGTC_2756 carbadox 75.1 µM -0.573955072175668 0.273347598297639 no 2460 0.282999102130103 3426 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_3247 9135149 49.47 µM -0.575151158927712 0.272945439868365 no 2461 0.282594535577865 3443 8934436 YOR116C RPO31
SGTC_2460 5552655 174.22 µM -0.575810938286619 0.272723728878642 no 2462 0.28237148964874 3474 5401989
SGTC_2245 6637752 200 µM -0.576360186780698 0.272539228653898 no 2463 0.282185874555162 3442 681890
SGTC_2138 5575593 77.673 µM -0.577113769455335 0.272286190609929 no 2464 0.281931301610886 3442 762213
SGTC_2374 9071832 200 µM -0.579842825715141 0.271370805870727 no 2465 0.281010307330546 3474 17381698
SGTC_967 1306-0166 352 µM -0.580260742385063 0.271230763055636 no 2466 0.280869398444355 3497 4437607
SGTC_3304 9125678 46.087 µM -0.582149889305823 0.270598164585131 no 2467 0.280232861664907 3454 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_2598 perillyl alcohol 100 µM -0.583518314424718 0.270140395376797 no 2468 0.279772215859611 3502 10819 An apoptosis inducer.
SGTC_2010 4012422 159 µM -0.583616878239939 0.270107438508278 no 2469 0.279739051025353 3429 952393
SGTC_1826 st055655 41.6 µM -0.584402383828136 0.269844860232002 no 2470 0.279474811655284 3465 676168
SGTC_1292 0kpi-0043 232 µM -0.584440265947179 0.269832200253822 no 2471 0.279462071401987 3457 3333905
SGTC_440 fluspirilene 35.1 µM -0.584827693795173 0.26970274125361 no 2472 0.279331790533044 3586 3396 An atypical antipsychotic.
SGTC_490 phenamil 164 µM -0.585907666663129 0.269342032668566 no 2473 0.278968782497007 3431 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1455 4262-0120 131 µM -0.586080301937634 0.269284395295667 no 2474 0.278910776400319 3576 1529587
SGTC_1811 st050069 61.5 µM -0.586594540466538 0.269112744232819 no 2475 0.278738025116265 3491 3877702
SGTC_2450 5739737 12.93 µM -0.586750158544366 0.269060810273893 no 2476 0.278685757654592 3492 2262825
SGTC_2288 7946289 167.31 µM -0.587229726040338 0.268900797278237 no 2477 0.278524715282349 3543 1246052
SGTC_2244 6635614 200 µM -0.588461859685583 0.26848990147523 no 2478 0.278111163513319 3329 836499
SGTC_1506 4226-2149 212 µM -0.58939832222408 0.268177818266931 no 2479 0.27779705087687 3476 991114
SGTC_2458 5808907 16.39 µM -0.5894246790778 0.268169037288421 no 2480 0.277788212644905 3582 2731747
SGTC_886 0866-0150 153 µM -0.589944943784467 0.267995736919235 no 2481 0.277613780623367 3562 271463
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.590739218415718 0.26773127254289 no 2482 0.277347583034601 3492 676296 Flavone; oxidizing agent.
SGTC_3015 9080845 49.47 µM -0.591290875352044 0.267547668397837 no 2483 0.277162771157599 3522 5296973
SGTC_3292 9120825 59.784 µM -0.591712229557236 0.267407474779924 no 2484 0.277021652900576 3552 24824900
SGTC_1981 st071826 47 µM -0.595341743554397 0.266201393634786 no 2485 0.275807529028651 3474 11838600
SGTC_1557 sumaresinolic acid 42.3 µM -0.59632299647093 0.265875798557486 no 2486 0.275479735614288 3467 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_728 3030-5151 22.5 µM -0.59681510649992 0.265712584764212 no 2487 0.275315415495128 3529 3125388
SGTC_3097 9117246 49.47 µM -0.596973131958493 0.265660184631192 no 2488 0.275262659557822 3548 16423892
SGTC_2166 5933061 31.504 µM -0.597752661815168 0.26540177470348 no 2489 0.275002490608432 3755 2877375
SGTC_1609 st001574 46.4 µM -0.598251261556488 0.265236558500792 no 2490 0.27483614594205 3426 3960012
SGTC_2795 7780010 54.55 µM -0.601421061692914 0.264187434998385 no 2491 0.273779787009441 3499 953673
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.601480709294837 0.264167713433398 no 2492 0.273759928277074 3533 688798
SGTC_2558 carylophyllene oxide 100 µM -0.6017739333411 0.264070774304029 no 2493 0.273662314296431 3583 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_607 4491-0986 66.8 µM -0.604384861613639 0.263208407945402 no 2494 0.2727938990426 3562 698981 YDR232W HEM1
SGTC_683 panaxydol 45 µM -0.604614701439294 0.263132562848221 no 2495 0.272717518030803 3522 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_2142 5622915 118.518 µM -0.605006693563714 0.263003234703054 no 2496 0.27258727460292 3500 5322196
SGTC_1119 parthenolide 318.541 nM -0.606239178105626 0.262596818564649 no 2497 0.272177970167396 3582 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2514 salinomycin 42.74 µM -0.606448376140517 0.26252786669227 no 2498 0.272108526462953 3571 23682228 A polyether potassium ionophore.
SGTC_846 0335-0850 148 µM -0.606955765869991 0.262360669056689 no 2499 0.271940134030307 3509 6819598
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM -0.607419990110234 0.262207743316106 no 2500 0.271786112775147 3506 521171
SGTC_2874 9043904 71.43 µM -0.60749160101403 0.262184157165704 no 2501 0.271762357430454 3446 4463428
SGTC_2968 9090663 33.37 µM -0.607533828123643 0.262170249528484 no 2502 0.271748349998533 3430 25236811
SGTC_2868 9035608 32.47 µM -0.60755629767683 0.262162849261446 no 2503 0.271740896621921 3535 6462614
SGTC_318 1488-0629 67.2 µM -0.608427798777589 0.261875906096604 no 2504 0.271451889477347 3531 3662576
SGTC_2400 5203494 178.7 µM -0.608728611901706 0.261776900288241 no 2505 0.271352169406388 3525 6777674
SGTC_841 0251-0215 91.2 µM -0.610624508249873 0.261153351240479 no 2506 0.270724096890239 3514 3888614
SGTC_2844 9010103 25.97 µM -0.611662465026694 0.260812297065729 no 2507 0.270380550319333 3544 2480525
SGTC_1780 st038448 24.544 µM -0.612266339097671 0.260613980251636 no 2508 0.270180778277225 3559 728868 YDL195W SEC31
SGTC_2100 5377183 190 µM -0.612952957551666 0.26038858389949 no 2509 0.269953722677106 3555 2844202
SGTC_2858 9025781 8.96 µM -0.612959606637094 0.260386401694125 no 2510 0.269951524379862 3579 4894980 YPL153C RAD53
SGTC_1401 3807-4679 7.6 µM -0.613183479739312 0.260312932864558 no 2511 0.269877513471671 3530 3291456
SGTC_821 1114-0266 29.2 µM -0.613726573634104 0.26013474917701 no 2512 0.269698012584959 3529 3123235
SGTC_298 1391-0729 10 µM -0.614414067967763 0.259909279348628 no 2513 0.269470870927926 3521 3237558
SGTC_1044 1222-0021 1.78 µM -0.61470156301732 0.259815022712069 no 2514 0.269375913710098 3506 4306703
SGTC_281 1672-3440 14.9 µM -0.615127486062339 0.259675414217011 no 2515 0.269235265724843 3533 6833000
SGTC_1163 k060-0048 49.9 µM -0.615879655203779 0.259428963810896 no 2516 0.268986974996764 3541 6809982
SGTC_1040 k898-0338 155 µM -0.616159236187294 0.25933738909899 no 2517 0.26889471473818 3596 20969351
SGTC_875 0709-0210 25.7 µM -0.617737065042428 0.258820896040913 no 2518 0.268374337539352 3568 6251364
SGTC_2998 9066762 71.4286 µM -0.618231294497781 0.258659222462525 no 2519 0.268211442000219 3603 4945196
SGTC_2865 9030313 51.95 µM -0.618588917020233 0.258542268698422 no 2520 0.268093602449723 3488 42562754
SGTC_3199 9111318 49.47 µM -0.619501845912643 0.258243836597685 no 2521 0.267792903124092 3508 8548020
SGTC_60 0986-0278 202 µM -0.620507367029112 0.257915343296704 no 2522 0.267461902654264 3399 3110598
SGTC_748 act1.228 77.9 µM -0.621009222244368 0.257751473551921 no 2523 0.267296777665891 3526 4421505 YNR035C ARC35
SGTC_2174 5790901 200 µM -0.621146617827841 0.257706619481608 no 2524 0.267251579486338 3538 786020
SGTC_759 3486-0358 89.3 µM -0.621310924848241 0.257652985242502 no 2525 0.267197533481451 3592 875103
SGTC_1516 st013856 110 µM -0.621691183113583 0.257528880929185 no 2526 0.267072475141185 3536 5281404 A mutagen and neurotoxin.
SGTC_2517 totarol 10 µM -0.621952449797028 0.257443629716689 no 2527 0.26698656757206 3514 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_3319 9138450 16.7555 µM -0.62545396294478 0.256302503989009 no 2528 0.265836577265981 3495 2029690
SGTC_1712 st032288 53.4 µM -0.626326481612122 0.256018565388141 no 2529 0.265550410078564 3572 2883011
SGTC_870 0573-2213 57.6 µM -0.626337803106517 0.256014882179762 no 2530 0.265546697901299 3566 3916321
SGTC_2308 7584454 197.62 µM -0.626789176086591 0.255868060065559 no 2531 0.265398719760888 3621 893577
SGTC_3313 9133968 57.047 µM -0.627036790894453 0.255787534858867 no 2532 0.265317559488965 3541 1494643
SGTC_1112 tnp00069 1.16933 µM -0.627946696421237 0.255491744044704 no 2533 0.26501942959447 3567 145826
SGTC_321 4534-3890 65.3 µM -0.630245169649981 0.254745356226357 no 2534 0.264267095232648 3560 699746
SGTC_2324 6149169 200 µM -0.631436914974317 0.254358808289628 no 2535 0.263877442703319 3474 2888231
SGTC_3086 9117350 49.47 µM -0.633195549240147 0.253788949467512 no 2536 0.263302975917107 3502 2679265
SGTC_1629 st005085 44.9 µM -0.633932185648071 0.253550452918184 no 2537 0.263062539831965 3552 24207091
SGTC_1833 st055984 71 µM -0.634429532855678 0.253389496273214 no 2538 0.262900270553416 3549 676288
SGTC_3059 1327-0034 3 µM -0.634675478166786 0.253309920758883 no 2539 0.262820044988966 3530 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM -0.634680662405126 0.253308243541882 no 2540 0.262818354063022 3588 66535 A nucleotide analog.
SGTC_1158 4092-0494 91.8 µM -0.639260869086069 0.251828728338252 no 2541 0.26132662007587 3630 1148199
SGTC_1851 st056236 18.9 µM -0.639294638645475 0.251817836938156 no 2542 0.261315637794046 3613 5393171
SGTC_3036 9090181 49.47 µM -0.639570813955568 0.251728773869404 no 2543 0.261225831038187 3594 25236586
SGTC_1917 st066507 28.5 µM -0.639731029686033 0.251677113933637 no 2544 0.261173739316793 3516 3156428
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM -0.640504445200656 0.251427812728612 no 2545 0.26092235006736 3532 689007
SGTC_2929 9013348 24.6 µM -0.640693487213164 0.251366897161117 no 2546 0.260860923205631 3566 2995952
SGTC_2036 5160441 105 µM -0.640830642823 0.25132270598671 no 2547 0.26081636084486 3587 134534 YIL048W NEO1
SGTC_198 3454-2873 16.191 µM -0.641247547356187 0.251188405670378 no 2548 0.260680931080707 3550 710957
SGTC_1056 3448-1962 115 µM -0.642481732876963 0.250791051626223 no 2549 0.260280223131594 3570 715507
SGTC_864 0469-0573 172 µM -0.643748452608116 0.250383569322575 no 2550 0.259869282454743 3517 689425
SGTC_1992 st073643 23.3 µM -0.644588755828592 0.25011345173965 no 2551 0.259596861728827 3580 3161292
SGTC_941 3237-0776 460 µM -0.645296908779307 0.249885934276965 no 2552 0.259367397780659 3600 760008
SGTC_3347 9188721 44.724 µM -0.646497623015165 0.249500416463894 no 2553 0.258978568006997 3574 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_3082 9117008 49.47 µM -0.647140615007176 0.249294098630166 no 2554 0.258770470606759 3551 41448529
SGTC_478 N-arachidonylglycine 10 µM -0.647516555932666 0.249173511919578 no 2555 0.258648841496729 3537 5283389
SGTC_2355 9061122 103.12 µM -0.647818381450167 0.249076720903577 no 2556 0.258551212555018 3562 5302957
SGTC_1640 st009078 66.4 µM -0.651783974102764 0.247806873516883 no 2557 0.257270270717599 3601 690618
SGTC_3102 9121669 49.47 µM -0.652117479275921 0.247700237506922 no 2558 0.257162694460326 3603 41905072
SGTC_2412 st077135 33.4 µM -0.652814411124867 0.24747747742404 no 2559 0.256937965921739 3671 13258915
SGTC_2391 6285546 200 µM -0.65294947620251 0.247434319007084 no 2560 0.256894425455281 3561 846083
SGTC_2353 9059630 146.67 µM -0.654303742371249 0.247001802031414 no 2561 0.256458067648493 3614 4779114
SGTC_2803 7707263 71.43 µM -0.656826463065151 0.246197191259773 no 2562 0.255646253240717 3593 2199229
SGTC_3043 9092303 49.47 µM -0.656907011099023 0.246171523990134 no 2563 0.255620354917861 3569 25236084
SGTC_3051 9093778 49.47 µM -0.656913502410122 0.246169455544871 no 2564 0.255618267849355 3609 17217378
SGTC_737 1950-0117 57.9 µM -0.659202970703461 0.245440502063182 no 2565 0.254882719771934 3592 5393513
SGTC_1057 3448-5381 134 µM -0.660848486642585 0.24491729657327 no 2566 0.254354742267956 3627 5497911
SGTC_1491 4138-0063 26.5 µM -0.661992386019404 0.244553938169621 no 2567 0.253988050674459 3589 23883227
SGTC_108 0509-0257 621.132 µM -0.662237973514305 0.244475965446405 no 2568 0.253909360642539 3602 536624
SGTC_1334 1486-0610 236 µM -0.662387409116998 0.244428526992782 no 2569 0.253861485426284 3611 3742339
SGTC_1102 cgs 12066b 26.1 µM -0.664764482190948 0.243674590609092 no 2570 0.253100571666805 3577 6438352 A 5-HT1B full agonist.
SGTC_3248 9135562 49.47 µM -0.666841875790144 0.243016733109695 no 2571 0.252436570610868 3649 17650701
SGTC_7 0192-1582 4.227 µM -0.667381032032083 0.24284615324614 no 2572 0.252264389306513 3663 252616
SGTC_817 1391-0715 46 µM -0.667411859956954 0.242836401773786 no 2573 0.252254546180059 3581 1353946
SGTC_858 0438-0351 2.77 µM -0.66746726320379 0.242818877181637 no 2574 0.252236856845659 3630 2799119
SGTC_2033 5192550 145 µM -0.667533700671713 0.242797863259275 no 2575 0.252215645330687 3599 182073
SGTC_3039 9090270 49.47 µM -0.670238628329065 0.241943141126151 no 2576 0.251352841465193 3615 17173750
SGTC_2038 4100038 30.985 µM -0.670274051313324 0.241931958759205 no 2577 0.251341552783897 3623 3596803
SGTC_3037 9091026 49.47 µM -0.670807508000444 0.241763590469588 no 2578 0.25117158194731 3638 25236398 YIL048W NEO1
SGTC_1735 st034310 56.75 µM -0.672039945417745 0.241374854882826 no 2579 0.250779133317483 3657 871153
SGTC_2430 5571206 200 µM -0.673120669294914 0.2410342524478 no 2580 0.250435262637141 3671 1731771
SGTC_1481 3346-2004 36 µM -0.673168816376722 0.241019084430222 no 2581 0.250419948749977 3638 2770522
SGTC_2456 5770359 74.46 µM -0.673318966426329 0.240971785237762 no 2582 0.250372194506938 3636 3118787
SGTC_31 0508-1974 57.237 µM -0.673689779865423 0.240854995877751 no 2583 0.250254280397903 3603 6810525
SGTC_901 1112-0062 60.1 µM -0.674484093461739 0.240604926904475 no 2584 0.250001797581081 3644 1908457
SGTC_244 nsc-207895 1.295 µM -0.674490759476595 0.240602828881348 no 2585 0.249999679274407 3513 42640
SGTC_2608 thymoquinone 42.66 µM -0.675383843141072 0.240321834942452 no 2586 0.249715963899649 3567 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_979 1426-2828 121 µM -0.67576482887486 0.240202018536167 no 2587 0.249594984164668 3696 747872
SGTC_3154 9100113 49.47 µM -0.676337585517491 0.240021953271566 no 2588 0.249413167332972 3627 25237525
SGTC_154 3389-1638 511.116 µM -0.67655909898402 0.239952332824138 no 2589 0.249342868607386 3562 5238686
SGTC_1638 st008370 60.6 µM -0.676635531207409 0.239928313158265 no 2590 0.249318614793404 3644 24207134
SGTC_2414 st077232 92.9 µM -0.679058668178223 0.23916749593969 no 2591 0.248550344790283 3610 729801
SGTC_2700 st077718 96.8 µM -0.679171666981586 0.239132048747775 no 2592 0.248514548653015 3631 904970
SGTC_2242 6630449 61.2675 µM -0.68093206408564 0.238580191447257 no 2593 0.247957239110403 3640 691249 YDR170C SEC7
SGTC_2769 toremifene 3.73 µM -0.685753835460493 0.237072216273344 no 2594 0.246434175982706 3669 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1573 oleylamine 1.06 µM -0.68715857322015 0.236633881643492 no 2595 0.245991403400626 3672 5356789 An amine of the fatty acid oleic acid.
SGTC_2409 alverine citrate 63.97 µM -0.687961733981879 0.236383463691072 no 2596 0.245738439481722 3744 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_2911 7942208 15.64 µM -0.68850912689313 0.236212875374909 no 2597 0.245566112401011 3636 1243384
SGTC_2309 7664088 163.95 µM -0.689138383849131 0.23601685892674 no 2598 0.245368093583616 3664 704922
SGTC_1824 st053723 68.6 µM -0.6903347542316 0.235644431352228 no 2599 0.244991848503791 3634 675225
SGTC_2521 angolensin 13.4 µM -0.69081690476743 0.235494430599195 no 2600 0.244840305361217 3670 821428 A flavenoid.
SGTC_384 k007-0144 5.16 µM -0.691612903542383 0.235246904569396 no 2601 0.244590228059238 3665 6824886
SGTC_1129 3453-1384 223 µM -0.69249849635456 0.234971687022213 no 2602 0.244312164930728 3733 1084452
SGTC_932 2857-0803 154 µM -0.692560273288663 0.234952495114278 no 2603 0.244292774240756 3734 674898
SGTC_828 2074-0507 139 µM -0.693234264427337 0.234743166196096 no 2604 0.244081274217633 3708 X828
SGTC_1469 k284-2957 126 µM -0.69372264412422 0.234591549135117 no 2605 0.243928081235295 3676 23884841
SGTC_1199 1638-0010 4.46 µM -0.693831916898851 0.234557632911759 no 2606 0.243893812093787 3648 3111136
SGTC_2267 7931562 200 µM -0.694028898315029 0.234496500420256 no 2607 0.243832043122797 3594 934880
SGTC_1411 3909-8223 150 µM -0.696139590778213 0.233842007952485 no 2608 0.243170707360778 3673 X1411
SGTC_387 norethindrone acetate 66.7 µM -0.696628592173197 0.233690520885531 no 2609 0.243017628778005 3665 541197
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.697850694491475 0.233312165486591 no 2610 0.242635285919619 3650 61125 An anti-inflammatory.
SGTC_3208 9114115 49.47 µM -0.698742913261387 0.233036154830738 no 2611 0.242356355154618 3660 650895
SGTC_3349 9149703 23.001 µM -0.699442445158083 0.232819879332869 no 2612 0.242137784885276 3664 4910494
SGTC_2399 5884133 200 µM -0.70003247127784 0.232637546664492 no 2613 0.241953513054079 3692 722445
SGTC_2274 7947094 46.08 µM -0.701006895949145 0.232336599200014 no 2614 0.241649355830907 3669 2971028
SGTC_1141 3253-0389 52.6 µM -0.702145045380858 0.231985360337801 no 2615 0.241294356489257 3646 5402031
SGTC_1279 0874-0590 65.2 µM -0.702847409607554 0.231768754678827 no 2616 0.241075424070404 3705 3523074
SGTC_489 paxilline 115 µM -0.705275000031881 0.231020966195053 no 2617 0.24031955762402 3660 105008 A toxic potassium channel blocker.
SGTC_1271 0832-2808 169 µM -0.706340421753276 0.230693202244417 no 2618 0.239988230836116 3701 3663794
SGTC_3064 1327-0027 10 µM -0.706426536278371 0.230666721517108 no 2619 0.239961461668733 3575 16000455 YPR107C YTH1
SGTC_1670 st016595 4.04 µM -0.70763099886719 0.23029652016593 no 2620 0.239587218653581 3697 597879
SGTC_3305 9127027 53.8275 µM -0.70783763043836 0.230233043681966 no 2621 0.23952304742907 3634 41905295
SGTC_1006 4099-6547 255 µM -0.707969613529733 0.230192504067573 no 2622 0.239482063848355 3701 3146833
SGTC_2930 9013230 14.89 µM -0.708244197219734 0.230108176386442 no 2623 0.23939681199411 3678 2995857
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.709506969799885 0.229720587590486 no 2624 0.239004963927215 3679 688803
SGTC_1977 st070720 65.3 µM -0.709622411119222 0.229685172886451 no 2625 0.23896915909778 3685 682188
SGTC_1840 st055363 71 µM -0.710022312432766 0.22956251613848 no 2626 0.238845149945527 3667 676033
SGTC_1286 0929-0070 131 µM -0.711910772188557 0.228983788511197 no 2627 0.238260015575653 3758 1420408
SGTC_201 4262-0159 12.803 µM -0.712112972333633 0.228921871853169 no 2628 0.238197410958181 3678 1341029
SGTC_1137 ixabepilone 100 µM -0.712783550858976 0.228716598108052 no 2629 0.237989852919445 3704 154225 A novel microtubule stabilizer.
SGTC_520 3584-0023 682 µM -0.713570304225623 0.228475893382243 no 2630 0.237746462795517 3710 1340790
SGTC_3049 9092223 49.47 µM -0.713615803059598 0.228461977511198 no 2631 0.237732391447951 3663 8623917
SGTC_3026 9090633 49.47 µM -0.71409441628464 0.228315621956681 no 2632 0.23758439922701 3703 25236842
SGTC_2303 7774051 200 µM -0.714296213376866 0.228253930044499 no 2633 0.237522016608271 3674 2953184
SGTC_470 aa-861 153 µM -0.714356661887394 0.228235451997652 no 2634 0.237503331585643 3693 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_2287 7945887 168.79 µM -0.718593512624553 0.226942418052165 no 2635 0.236195705859413 3729 1245853
SGTC_3110 9122132 49.47 µM -0.719237495116136 0.226746244979998 no 2636 0.235997300293919 3818 918317
SGTC_1521 st012942 49.4 µM -0.719367601960983 0.226706622823296 no 2637 0.23595722662895 3751 24207259
SGTC_260 nsc-65238 3.989 µM -0.720751454832332 0.226285432323169 no 2638 0.235531224054375 3640 3246252
SGTC_3194 9111903 49.47 µM -0.720781307932757 0.226276351084669 no 2639 0.235522038812245 3703 17087251
SGTC_67 0335-0847 266 µM -0.721284588958148 0.226123285251537 no 2640 0.235367218383973 3819 4552207 YOR254C SEC63
SGTC_2564 betulinic acid 100 µM -0.72183106691934 0.225957147964206 no 2641 0.235199173251177 3721 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_1100 amiodarone 5.07 µM -0.722952714999776 0.225616366837686 no 2642 0.234854467622446 3766 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_2133 5320837 200 µM -0.723505799154032 0.225448434938244 no 2643 0.234684596278674 3680 2841355
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -0.723636306359401 0.225408819602093 no 2644 0.234644522894764 3771 6728940
SGTC_1169 aniline yellow 25.8 µM -0.724050508948935 0.225283114912446 no 2645 0.234517363417545 3668 6051 A DNA damaging agent.
SGTC_1224 0823-0416 294 µM -0.725365838489215 0.22488419412556 no 2646 0.234113812375392 3750 3598164
SGTC_3163 9099914 49.47 µM -0.726133399100772 0.224651589027293 no 2647 0.233878497938374 3722 16268368
SGTC_2115 tiliquinol 12.7705 µM -0.731486525827115 0.223033152614378 no 2648 0.232241015847928 3723 71208 A bioactive hydroxyquinoline.
SGTC_1805 st050013 60.3 µM -0.731625220961118 0.222991308688065 no 2649 0.232198674982211 3701 4037144
SGTC_3165 9101544 49.47 µM -0.732941156406138 0.222594517251119 no 2650 0.231797159876502 3726 5002184
SGTC_2804 7954240 19.48 µM -0.73396109930729 0.222287252963208 no 2651 0.231486223568514 3739 828705
SGTC_1744 st037937 38.9 µM -0.734033425691035 0.222265473372272 no 2652 0.231464183227448 3767 1016152
SGTC_3159 9100096 49.47 µM -0.734534868744498 0.222114507680652 no 2653 0.231311408432885 3700 25236875
SGTC_1695 st026914 34.495 µM -0.734630573218045 0.222085701306659 no 2654 0.231282256517383 3693 3289191
SGTC_3308 9128332 17.569 µM -0.736540706647037 0.221511210774593 no 2655 0.230700852058739 3713 17332805 YDL196W YDL196W
SGTC_358 0075-0058 9.45 µM -0.737375979182723 0.221260261930096 no 2656 0.230446869470213 3704 1069125
SGTC_3215 9129942 49.47 µM -0.738287583530682 0.220986565672039 no 2657 0.230169855026227 3664 17682944
SGTC_836 0330-0104 1.35 µM -0.738341540871302 0.220970371823443 no 2658 0.230153464540692 3746 46494820
SGTC_573 3702-0553 84.7 µM -0.738838303003544 0.22082131391005 no 2659 0.230002595039883 3698 1222756
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM -0.739386038344557 0.22065702778858 no 2660 0.229836308860429 3804 5393153
SGTC_623 k072-0108 16.9 µM -0.740341789563809 0.220370530325111 no 2661 0.229546314988273 3741 5382803
SGTC_2627 acetyl isogambogic acid 100 µM -0.742399573929987 0.219754410025557 no 2662 0.228922638817841 3730 6857789 A caspase activator and apoptosis inducer.
SGTC_2977 9011197 71.43 µM -0.744221068560998 0.219209863179082 no 2663 0.228371371987803 3760 2704722
SGTC_439 amiodarone 34.4 µM -0.744724727125502 0.219059428410835 no 2664 0.228219073839533 3665 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_1928 4'-methoxychalcone 40.3 µM -0.746343129188352 0.218576439635239 no 2665 0.227730082118084 3783 641818
SGTC_1281 0884-0031 11.8 µM -0.746832873913108 0.218430403306103 no 2666 0.227582224624928 3770 1548255
SGTC_1547 harmine 94.2 µM -0.747554194619284 0.218215416009616 no 2667 0.227364551129161 3774 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_1523 st012844 44.7 µM -0.747911374613163 0.218109004824313 no 2668 0.227256808087848 3858 4274103
SGTC_2125 5246583 200 µM -0.748341175175716 0.217980998151811 no 2669 0.227127197264374 3763 835267
SGTC_2279 7948423 32.93 µM -0.748764826968595 0.217854865155956 no 2670 0.226999481457025 3728 1247112
SGTC_3352 9151559 45.5865 µM -0.74900119662204 0.217784509593 no 2671 0.22692824209587 3758 17159339
SGTC_2346 9031566 143.75 µM -0.749699041039097 0.217576872285336 no 2672 0.226717992613407 3737 4771086
SGTC_2881 9058953 51.95 µM -0.752173286614942 0.216841604144833 no 2673 0.225973428022955 3738 17122249
SGTC_2057 5236571 38.335 µM -0.752759128545613 0.216667720879176 no 2674 0.225797335637597 3741 54684039 YBR257W POP4
SGTC_1661 st013063 9.66 µM -0.753515428620384 0.21644336337472 no 2675 0.225570121752716 3799 721395
SGTC_3343 9148379 18.9835 µM -0.754868652253268 0.216042263306619 no 2676 0.225163898245641 3802 1955036
SGTC_3012 9080433 71.4286 µM -0.755420166722737 0.215878916127205 no 2677 0.224998458344018 3762 17688859
SGTC_3252 9135871 49.47 µM -0.759220960239879 0.214755147500024 no 2678 0.223860194841832 3779 17682838
SGTC_2650 prasterone 100 µM -0.759836413650262 0.214573498626538 no 2679 0.223676186922635 3719 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_102 gallobenzophenone 83.616 µM -0.760288720110621 0.214440058949038 no 2680 0.223541011431291 3786 70837
SGTC_2048 5246248 200 µM -0.760554421010612 0.214361694240789 no 2681 0.223461626209843 3740 677046
SGTC_2523 spermine 47.74 µM -0.765353724475763 0.212949077747113 no 2682 0.222030470361805 3760 1103 A DNA binding polyamine.
SGTC_1765 st044815 90.4 µM -0.765957521294603 0.212771743018674 no 2683 0.221850789022863 3812 645695
SGTC_334 1502-1024 68.5 µM -0.766229510337518 0.212691888188654 no 2684 0.221769876095139 3823 3296216
SGTC_365 0121-0052 13.6 µM -0.767106992990449 0.212434382327991 no 2685 0.221508952262458 3810 3101739
SGTC_1131 3454-3128 32.3 µM -0.768802348884913 0.211937379824767 no 2686 0.221005327136121 3866 710982
SGTC_89 0302-0250 142.109 µM -0.76986881841429 0.211625087468674 no 2687 0.220688856077911 3849 4203518 YLR208W SEC13
SGTC_3322 9139058 2.11 µM -0.77040617166016 0.21146783739231 no 2688 0.220529496798342 3896 4908926 YPR165W RHO1
SGTC_1561 5-methoxyflavone 52.9 µM -0.771101624744685 0.211264422882647 no 2689 0.220323348825404 3736 94525
SGTC_1230 0170-0365 3.77 µM -0.77135631129566 0.211189957774392 no 2690 0.220247881636153 3869 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_2317 5986382 200 µM -0.771915984461483 0.211026374897636 no 2691 0.220082094729302 3825 877883
SGTC_3287 9117173 37.0625 µM -0.772812869392339 0.210764385742044 no 2692 0.219816567970806 3776 2789709
SGTC_1959 st077091 55.8 µM -0.773261089218071 0.210633527727448 no 2693 0.219683939446208 3794 821356 YKL052C ASK1
SGTC_2991 9074669 71.4286 µM -0.773297378636781 0.210622935098918 no 2694 0.219673203395718 3755 17333109
SGTC_2471 5466956 24.79 µM -0.774947558369669 0.210141589472131 no 2695 0.219185324059616 3755 724419
SGTC_1565 sinapyl alcohol 95.1 µM -0.775158795991761 0.210080019654865 no 2696 0.219122916187495 3817 5280507 A phenol propionate derived from cinnamic acid.
SGTC_59 0330-0160 1.33 µM -0.775337800402758 0.210027853207437 no 2697 0.219070039267308 3763 4293482
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.778717953129893 0.209044220200083 no 2698 0.218072939043264 3725 756377
SGTC_95 0471-0001 561.058 µM -0.778974588865195 0.208969649524385 no 2699 0.217997341905976 3734 4015405
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.779586693434181 0.208791853493208 no 2700 0.21781709539235 3833 115019
SGTC_663 1486-0733 13.9 µM -0.780110507451705 0.208639773736843 no 2701 0.217662916088562 3819 722445 YPR165W RHO1
SGTC_933 2914-0560 114 µM -0.781513319675294 0.208232814762458 no 2702 0.21725032291955 3829 463887
SGTC_2282 7944268 200 µM -0.78387987930227 0.207547333035251 no 2703 0.216555298529691 3805 2970414
SGTC_2611 pyromycin 23.93 µM -0.783918268257722 0.207536224551596 no 2704 0.216544034860981 3819 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_1556 plumbagin 1.48 µM -0.784585757544962 0.207343131584363 no 2705 0.216348241623649 3723 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2950 9072895 21.46 µM -0.786560346875936 0.206772539691502 no 2706 0.215769639758296 3750 17332245
SGTC_603 3794-0023 45.9 µM -0.787762747179772 0.206425541090138 no 2707 0.21541774755627 3802 3802260
SGTC_740 k014-0057 261 µM -0.788712515078282 0.206151693295484 no 2708 0.215140025779829 3823 4012779
SGTC_2005 4024620 188 µM -0.788983911834269 0.206073480706056 no 2709 0.215060704811763 3797 236743
SGTC_1070 indatraline 8.81 µM -0.789226916258299 0.206003465306038 no 2710 0.214989696464466 3813 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2534 helenine 20.12 µM -0.79293593291061 0.204936560794016 no 2711 0.213907575327867 3824 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_2296 7971656 126.45 µM -0.793503252173507 0.20477366067202 no 2712 0.213742337631718 3887 666570
SGTC_1948 st076329 66.6 µM -0.794057415227828 0.204614612603866 no 2713 0.213581003620742 3704 24208413
SGTC_1237 0330-0133 46.1 µM -0.795409545298296 0.204226851869686 no 2714 0.213187654626311 3765 X1237 YHR072W ERG7
SGTC_2947 9072639 7.68 µM -0.796687357580939 0.203860806304016 no 2715 0.212816314058594 3866 16488146
SGTC_1171 0368-0077 21.4 µM -0.797745836158571 0.203557887978917 no 2716 0.21250899940574 3799 3239779
SGTC_1122 capsaicin 818.572 nM -0.797774293715587 0.203549747624043 no 2717 0.21250074072667 3928 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_883 0850-0245 24.6 µM -0.798738141905984 0.203274151122747 no 2718 0.21222113268774 3924 6823229 YPR165W RHO1
SGTC_1348 1493-0373 93.8 µM -0.799446419963339 0.203071772709346 no 2719 0.212015801551334 3833 3010129
SGTC_2716 st080858 38.6235 µM -0.799799521523713 0.202970924894933 no 2720 0.211913480161616 3822 5296050
SGTC_1182 1222-0449 220 µM -0.799900038937106 0.202942222019836 no 2721 0.211884357616769 3834 658318
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM -0.800190171723044 0.202859387832384 no 2722 0.211800311632487 3901 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_2469 5655019 90.81 µM -0.80147524834936 0.202492735713903 no 2723 0.211428283843036 3905 2788239
SGTC_143 4032-1194 15.74 µM -0.802324750921177 0.202250577237824 no 2724 0.21118256434833 3850 1806963
SGTC_703 3875-0075 71.8 µM -0.80484305853067 0.20153372927262 no 2725 0.210455125310618 3868 2850814
SGTC_2714 st079313 56.9 µM -0.805724440202746 0.201283199960929 no 2726 0.210200877034407 3819 2939799
SGTC_1121 fusaric acid 630.51 nM -0.806840533205357 0.200966222914326 no 2727 0.209879181613662 3853 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2606 farnesol 9.78 µM -0.807105653589609 0.200890971189897 no 2728 0.209802807586323 3857 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_3183 9108214 49.47 µM -0.807929581131039 0.200657215681897 no 2729 0.209565560609064 3789 4974831
SGTC_1374 2889-5571 141 µM -0.809685003699966 0.200159731702817 no 2730 0.209060619558356 3878 2853281
SGTC_2647 atorvastatin 60.16 µM -0.811573840630084 0.199625267090209 no 2731 0.20851810337094 3838 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_3242 9133940 49.47 µM -0.813204195980848 0.199164633574114 no 2732 0.208050497050043 3855 17248444
SGTC_793 0488-0545 106 µM -0.813297453573453 0.199138304352745 no 2733 0.208023768334074 3846 292548
SGTC_1261 0712-0010 12.7 µM -0.813621498692031 0.199046833673274 no 2734 0.207930908976289 3830 2840123
SGTC_2022 5136654 200 µM -0.815856064227818 0.198416755340872 no 2735 0.207291231661958 3903 1713771
SGTC_2788 5282734 71.43 µM -0.816132352226591 0.198338934358842 no 2736 0.207212221064596 3916 743706
SGTC_963 1269-2853 151 µM -0.81860325556279 0.197643783788127 no 2737 0.206506404482607 3860 3668223
SGTC_2434 5670830 169.91 µM -0.818843900971656 0.197576160695634 no 2738 0.206437740016356 3897 1549830
SGTC_706 4262-0057 46.9 µM -0.819542751704371 0.197379857910772 no 2739 0.206238410407083 3846 883298
SGTC_345 1362-0200 395 µM -0.820141125929043 0.197211872117611 no 2740 0.206067829892497 3857 1419823
SGTC_2310 7668677 200 µM -0.821061286010597 0.196953717963316 no 2741 0.205805680132828 3838 2197143
SGTC_2485 5633444 17.78 µM -0.821729817548205 0.19676628745012 no 2742 0.205615342462584 3899 5724239
SGTC_2915 7971052 15.16 µM -0.823357510376351 0.196310396909564 no 2743 0.205152359044306 3709 5741558
SGTC_3157 9099274 49.47 µM -0.823604639407561 0.196241236081576 no 2744 0.205082119495942 3827 17217662
SGTC_2553 4-methylesculetin 85.09 µM -0.824621340192637 0.195956860534166 no 2745 0.204793300990361 3914 5319502
SGTC_1519 esterone 74 µM -0.824686491138837 0.195938646064401 no 2746 0.204774801535711 3852 698 A steroid.
SGTC_3301 9125354 19.7965 µM -0.824981717894866 0.195856121398932 no 2747 0.204690985064565 3840 41905162
SGTC_199 4063-0024 41.6 µM -0.825334320389312 0.195757586150326 no 2748 0.204590906058847 3880 306215
SGTC_1176 0848-0131 83.3 µM -0.827839616569435 0.195058344464771 no 2749 0.203880667708911 3924 6769040
SGTC_1868 st057644 42.7 µM -0.828030655183695 0.195005086933053 no 2750 0.203826569626053 3873 688665
SGTC_2678 equilin 100 µM -0.82882758985154 0.194783013754113 no 2751 0.203600986943303 3881 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_477 mead ethanolamide 10 µM -0.830677989182511 0.194267976536434 no 2752 0.203077781959426 3732 16061185
SGTC_1740 st038286 13.222 µM -0.832828057956893 0.193670572552784 no 2753 0.202470854079513 3921 716786
SGTC_329 k048-0121 21.3 µM -0.83384728151974 0.193387769591948 no 2754 0.20218352389557 3895 6832902
SGTC_2197 6588183 93.1375 µM -0.834551852976183 0.193192420212701 no 2755 0.201985040240148 3820 884136
SGTC_2927 9011802 47.9 µM -0.834609188481115 0.193176528680501 no 2756 0.201968893483413 3901 43912568
SGTC_3132 9126706 49.47 µM -0.83536955900589 0.192965854235426 no 2757 0.201754831914372 3938 850858
SGTC_1578 josamycin 24.2 µM -0.835812232691247 0.192843268110422 no 2758 0.201630271819593 3897 5282165 A P450 substrate.
SGTC_1502 4534-4282 27.7 µM -0.835971243566368 0.192799246101234 no 2759 0.201585540381636 3856 3278949
SGTC_1878 temozolomide 1 mM -0.836370734734988 0.192688674442979 no 2760 0.201473185532113 3788 5394 DNA alkylating agent.
SGTC_3069 9117009 49.47 µM -0.83735683974866 0.192415905007954 no 2761 0.201196009220111 3834 41904981
SGTC_2616 abietic acid 100 µM -0.841434150224236 0.191290576460881 no 2762 0.200052380336887 3892 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_2747 doxorubicin 7.63 µM -0.845610167603732 0.190142196283662 no 2763 0.198885125786525 3785 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_1678 st019265 80.2 µM -0.845811398339332 0.190086966213612 no 2764 0.198828982882936 3874 5367020
SGTC_856 0433-0016 11.3 µM -0.850308529299706 0.188855250746136 no 2765 0.197576787886949 3951 3911780
SGTC_861 0443-0273 110 µM -0.850813583584907 0.188717229683101 no 2766 0.197436457390787 3935 6149169
SGTC_1275 0867-0008 21.1 µM -0.851538208699358 0.18851931300597 no 2767 0.197235223937086 3870 3422836
SGTC_2781 5567276 71.43 µM -0.852139475422502 0.188355186377719 no 2768 0.197068342201528 3960 2853274
SGTC_1309 pyrazolanthrone 13.4 µM -0.853482487917943 0.187988905269886 no 2769 0.196695897467541 3906 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1924 st058459 75.1 µM -0.854763344118996 0.187639986082271 no 2770 0.196341087440607 3841 688683
SGTC_811 0416-0114 265 µM -0.854842435186737 0.187618453937287 no 2771 0.196319191146111 3992 6612453
SGTC_2728 chlorpromazine 9.18 µM -0.857387370082781 0.186926423289189 no 2772 0.195615418485314 3913 2726 A thorazine and dopamine antagonist.
SGTC_1453 4237-0541 195 µM -0.857555128139121 0.186880861286361 no 2773 0.195569080789443 3843 739892
SGTC_3270 9137563 49.47 µM -0.860590300217806 0.186057715518119 no 2774 0.194731865040302 3904 17015724
SGTC_136 0097-0015 404.482 µM -0.861429457239883 0.185830531378735 no 2775 0.194500778956934 3919 4861337
SGTC_2742 clothiapine 36.27 µM -0.863391974770653 0.185299893028705 no 2776 0.193960995158226 3865 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_968 1309-0633 340 µM -0.864006221287187 0.185134002539914 no 2777 0.193792236483008 3959 3761976
SGTC_1701 st028638 40.4 µM -0.864618698396459 0.184968681798426 no 2778 0.193624053088526 3873 3490878
SGTC_1338 1486-1223 76 µM -0.864643199123582 0.184962070434026 no 2779 0.193617327153698 3948 3444526
SGTC_3209 9113616 49.47 µM -0.86553610912797 0.184721224579963 no 2780 0.193372302899975 3916 16649353
SGTC_2996 9066192 71.4286 µM -0.868563867983285 0.183905995374925 no 2781 0.192542862294911 3998 6472854
SGTC_2516 gossypol 71.55 µM -0.869542504049613 0.183642975831872 no 2782 0.192275235201203 3969 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_2275 7947463 200 µM -0.870034796683729 0.183510755258627 no 2783 0.192140694247573 3865 1225414
SGTC_24 0417-1663 219 µM -0.871498188369229 0.183118066146344 no 2784 0.191741097304902 3911 4329390
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.873618453136918 0.182550041272343 no 2785 0.191163036731865 3729 88881 An O-methylated flavonoid and antioxidant.
SGTC_2320 7373003 200 µM -0.874201232237693 0.182394106129501 no 2786 0.191004337550279 4015 5415828
SGTC_958 1222-0007 33 µM -0.875180217639467 0.18213234480928 no 2787 0.190737927608671 4024 7312461
SGTC_2390 9097792 176.6 µM -0.876404997800704 0.181805193689506 no 2788 0.190404951163244 3944 4497149
SGTC_17 0960-0276 49.807 µM -0.87676913621521 0.181707999584555 no 2789 0.190306023087598 3920 6821114
SGTC_2638 epoxomicin 18 µM -0.877500932416068 0.181512770339642 no 2790 0.19010730630887 3942 9915668 A protesome inhibitor.
SGTC_2446 5162541 200 µM -0.879225096194156 0.181053315698416 no 2791 0.189639619859385 3905 1549321
SGTC_2407 paclitaxel 400 µM -0.8807014684011 0.18066047211711 no 2792 0.189239710906544 4110 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_2818 7996756 12.99 µM -0.881024722795513 0.180574529673889 no 2793 0.189152219447187 3952 2241621
SGTC_807 1315-0151 48 µM -0.881593690745955 0.180423322577258 no 2794 0.188998284112247 3944 4011080
SGTC_2055 5235184 200 µM -0.8824561619436 0.180194266516185 no 2795 0.188765088129221 4009 2836034
SGTC_209 4077-0173 175.592 µM -0.882849060816611 0.180089980536122 no 2796 0.188658914484944 3918 15993494
SGTC_190 3970-0790 3.722 µM -0.885111299519128 0.179490258649085 no 2797 0.188048302859788 3858 2832352
SGTC_2148 5546263 113.568 µM -0.892086780022739 0.17764896656957 no 2798 0.186173210103445 3934 792097
SGTC_2030 5175110 200 µM -0.896321948799426 0.176536861012729 no 2799 0.185040419924178 4026 2831986
SGTC_219 mitoxanthrone 164.414 µM -0.897030353448707 0.176351273043062 no 2800 0.184851360217852 3931 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_452 diindolylmethane 8 µM -0.897109848522191 0.176330454616508 no 2801 0.184830151991652 3973 3071 Inhibits expression of several cancer promoting factors.
SGTC_1567 st069303 68.4 µM -0.898138628830146 0.176061174601456 no 2802 0.184555823562861 4043 5581319
SGTC_96 0929-0093 37.281 µM -0.89957337218494 0.175686069998538 no 2803 0.184173666508623 3940 6991579
SGTC_3029 9088683 49.47 µM -0.900307664086441 0.175494290042473 no 2804 0.183978271805776 3998 25236615
SGTC_2193 5925765 200 µM -0.900375146904965 0.175476671760866 no 2805 0.18396032114065 3956 877370
SGTC_1284 0929-0043 16 µM -0.900854850398808 0.175351464028158 no 2806 0.183832749771127 3942 1239883
SGTC_1771 st048882 4.1505 µM -0.901637131362177 0.17514740188223 no 2807 0.183624829798604 3994 4580403
SGTC_2063 5246145 200 µM -0.905295261154063 0.174195159469909 no 2808 0.182654493131833 4020 711240
SGTC_467 ro 31-8220 72.8 µM -0.90565283523395 0.174102256735747 no 2809 0.182559816955659 3906 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_914 3820-6779 408 µM -0.90675338427989 0.173816516429182 no 2810 0.182268613003956 3927 2893481
SGTC_1645 Cervolide 78 µM -0.906807285599641 0.173802529462718 no 2811 0.182254358240312 3948 23173 A fragrance.
SGTC_1157 4092-0394 27.6 µM -0.908565617209043 0.173346648928352 no 2812 0.181789731308536 4077 3659885
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM -0.909987412833176 0.172978578860762 no 2813 0.181414573996182 3980 688751
SGTC_1162 k048-0130 20.1 µM -0.911761507529971 0.172520005527572 no 2814 0.180947138742107 3954 6797406
SGTC_186 3455-3465 67.277 µM -0.912244914361744 0.172395187602345 no 2815 0.18081990255024 3933 755278
SGTC_183 3914-0051 30.55 µM -0.91304255583953 0.172189358785781 no 2816 0.180610080164784 4020 1596232
SGTC_2090 5301565 104.445 µM -0.913244644913006 0.172137235260412 no 2817 0.18055694417847 3978 2056344
SGTC_1751 st044839 27.194 µM -0.913667048972616 0.172028319843482 no 2818 0.180445911671217 3950 5291326
SGTC_3315 9136395 68.55 µM -0.913836468115876 0.171984648070206 no 2819 0.180401390443154 3959 16876844
SGTC_1903 st060211 78.3 µM -0.913987605549687 0.171945694812038 no 2820 0.180361679236089 4040 688960
SGTC_78 0336-0123 156.75 µM -0.917880321280172 0.170944350904501 no 2821 0.179340762588627 3814 6765896
SGTC_610 4215-0184 155 µM -0.91817742829149 0.170868078037022 no 2822 0.179262991843011 4012 5605015
SGTC_1025 k007-0731 70 µM -0.919931941710478 0.170418106064055 no 2823 0.178804162869828 3964 6256118
SGTC_1175 0741-0056 27.6 µM -0.921510194906967 0.17001398774395 no 2824 0.178392060515735 4096 765927
SGTC_1982 st072467 71.9 µM -0.922925377399654 0.169652147134682 no 2825 0.178023047320211 3977 3163533
SGTC_3342 9147791 14.508 µM -0.923675653375434 0.16946051351376 no 2826 0.177827605908722 3904 1838168
SGTC_2928 9011484 9.79 µM -0.925357323272024 0.169031490389683 no 2827 0.177390035054202 4036 2994751
SGTC_2491 paeonol 100 µM -0.92612907058206 0.168834838015514 no 2828 0.177189454003542 3862 11092 Increases levels of cortical cytochrome oxidase.
SGTC_3109 9122853 49.47 µM -0.928455372709184 0.168242952389819 no 2829 0.176585703391342 4067 1234709
SGTC_3314 9135860 59.4275 µM -0.928780652865246 0.168160297217391 no 2830 0.17650138646861 4006 25252478
SGTC_1397 3532-0190 20.1 µM -0.929512275155135 0.167974484139573 no 2831 0.176311833354399 3942 5322280
SGTC_2032 5185112 25.99 µM -0.930381297623598 0.167753946758157 no 2832 0.17608684921003 3882 5718189
SGTC_1498 4478-3555 97.6 µM -0.93069866874056 0.167673451963348 no 2833 0.176004729263488 3939 3437919
SGTC_2583 asiatic acid 100 µM -0.932498158307498 0.167217518131996 no 2834 0.175539569010325 4025 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1842 st055362 61.2 µM -0.937942904330492 0.165842863788398 no 2835 0.174136876372629 3974 676032
SGTC_1078 idebenone 36.1 µM -0.939012013509577 0.165573802418853 no 2836 0.173862288170532 4065 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_3330 9141424 71.43 µM -0.941287528645433 0.165002066859637 no 2837 0.173278766036158 4096 27261020
SGTC_755 1995-0008 37.3 µM -0.943963437499616 0.164331367677363 no 2838 0.172594166264147 3985 689533
SGTC_3107 9121808 49.47 µM -0.944073670277912 0.164303776507048 no 2839 0.172566001540851 3905 662681
SGTC_2629 bisabolol 100 µM -0.944861146860186 0.164106759170252 no 2840 0.172364884756794 4063 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_2248 tofa 1.1 µM -0.946672284278788 0.163654215751727 no 2841 0.171902898821656 3969 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2952 9073731 13.78 µM -0.949305639728755 0.162997674038191 no 2842 0.171232593005713 4109 16457353
SGTC_709 3807-1509 243 µM -0.951253505793431 0.162513140077254 no 2843 0.170737851436023 4101 1886677 YPL242C IQG1
SGTC_2092 5303694 80.6725 µM -0.951355438308264 0.162487810077775 no 2844 0.170711986652278 4027 1963699
SGTC_3093 9117344 49.47 µM -0.95199750737069 0.162328316430364 no 2845 0.170549123012897 4069 24824913
SGTC_1096 rimcazole 32.2 µM -0.952840597096743 0.162119042909264 no 2846 0.170335420733747 3959 18528119 A dopamine reuptake inhibitor.
SGTC_1602 st001878 87.6 µM -0.95537667063034 0.161490592985242 no 2847 0.169693623697242 4061 595405 YLR310C CDC25
SGTC_2581 avocatin a 64 µM -0.958312424693693 0.1607650868712 no 2848 0.168952620223933 4022 6710728 A skin care supplement.
SGTC_538 2922-0838 53.3 µM -0.959765457913983 0.160406790715019 no 2849 0.168586635300108 4007 777039
SGTC_1898 st060199 18.6 µM -0.96058104724956 0.160205907451237 no 2850 0.168381430995601 4013 688866
SGTC_660 4031-1742 102 µM -0.961462372372261 0.15998901811744 no 2851 0.168159868056832 3962 6738706
SGTC_2162 5663267 200 µM -0.96587599551142 0.158905739498297 no 2852 0.167053117620908 4031 6456493
SGTC_681 1642-0006 26.6 µM -0.969086522185952 0.158120775718414 no 2853 0.16625101085632 4071 4446530
SGTC_2345 9052315 157.45 µM -0.969136529553856 0.158108569237073 no 2854 0.166238536896654 4105 6469265
SGTC_1152 3909-8331 15.9 µM -0.969146393188931 0.158106161659342 no 2855 0.166236076558872 4020 16001939
SGTC_2770 toltrazuril 17.5 µM -0.969285974179737 0.158072094437948 no 2856 0.166201262667885 3944 68591 Kills coccidiodes.
SGTC_2281 7943571 200 µM -0.971187894121255 0.157608377254513 no 2857 0.165727360570744 4165 1244024
SGTC_541 4513-1321 94 µM -0.971476087389237 0.157538189382569 no 2858 0.165655627643901 4040 747515
SGTC_3290 9121031 71.43 µM -0.973387938602869 0.157073088785907 no 2859 0.165180265594955 4074 17014854
SGTC_3153 9100258 49.47 µM -0.974258395970982 0.156861630052342 no 2860 0.164964128162098 3998 25236848
SGTC_159 3970-0959 50 µM -0.974590353932467 0.156781037427738 no 2861 0.16488175016513 4144 6615653
SGTC_227 fluconazole 33.516 µM -0.975225738503111 0.156626855016393 no 2862 0.164724148765969 4059 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_2411 st077133 39.94 µM -0.976463488411114 0.156326789344977 no 2863 0.164417416420375 4143 1403142 YNL221C POP1
SGTC_1297 1068-0111 14.1 µM -0.977282340465171 0.156128484638525 no 2864 0.164214696657796 4028 767057
SGTC_2046 4110841 106 µM -0.979458623115392 0.155602251504288 no 2865 0.16367671172572 4067 44119630 YMR134W ERG29
SGTC_3185 9108267 49.47 µM -0.981741615751612 0.15505147432277 no 2866 0.163113578867812 4072 4910486
SGTC_523 1934-0222 13.7 µM -0.982439959019116 0.154883254843448 no 2867 0.16294157429237 4025 1361595
SGTC_2238 6671620 73.2395 µM -0.98325969794311 0.154685946995601 no 2868 0.162739820021235 3996 729941
SGTC_1803 st050068 52.4 µM -0.983505290431852 0.154626866223723 no 2869 0.162679406404976 4136 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_259 usnic acid 108.925 µM -0.985069713007368 0.154250872170968 no 2870 0.162294914554287 4163 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_1937 st074714 47.2 µM -0.986213371062921 0.153976387754109 no 2871 0.162014209618989 4034 17250970
SGTC_2820 7989630 71.43 µM -0.98927432174043 0.153243333241703 no 2872 0.161264471980598 4064 2984098
SGTC_2910 7948405 25.97 µM -0.990327128327239 0.152991736272042 no 2873 0.161007125449874 3994 2971328
SGTC_3203 9113543 49.47 µM -0.992360611438048 0.152506555486409 no 2874 0.160510822984801 4171 17018012
SGTC_2226 7298446 200 µM -0.992891847361621 0.152379973149938 no 2875 0.160381331610131 4064 3283010
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.996681461276724 0.151479011450453 no 2876 0.159459575523635 4003 5355888
SGTC_2885 9057732 51.95 µM -0.996741704984537 0.151464717470225 no 2877 0.159444950374226 4167 6471414
SGTC_3127 9126946 49.47 µM -0.997945619752354 0.151179253543614 no 2878 0.159152864424143 4090 27243249
SGTC_423 5-fluorouracil 457 µM -0.998596810396654 0.151024996983822 no 2879 0.158995022949386 4020 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2712 st079126 47.7 µM -0.998660399134402 0.151009939452956 no 2880 0.158979615235328 4090 3152970
SGTC_546 peri-Naphthalide 147 µM -0.998715193767894 0.150996965128349 no 2881 0.158966339140062 4008 223824 A penicillin ester.
SGTC_567 1080-0542 68.4 µM -1.00199077728386 0.150222717031431 no 2882 0.158174023597893 3959 5950415
SGTC_2545 solidagenone 89.61 µM -1.00317129172656 0.149944329189276 no 2883 0.157889110933506 3887 6708572 An anti ulcer agent
SGTC_600 1495-0418 41.6 µM -1.00330821860272 0.149912061498063 no 2884 0.157856085978224 4078 5377768
SGTC_1541 2',3',6-trimethoxyflavone 64 µM -1.01118906287124 0.148062692627599 no 2885 0.155962974744379 4204 688801
SGTC_2670 beta-carotene 100 µM -1.01197502006205 0.147879095845118 no 2886 0.155774998671951 4030 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_661 1304-0007 33.6 µM -1.0124608558906 0.147765682595193 no 2887 0.155658876870175 4101 3117130
SGTC_2812 7970281 58.44 µM -1.01370491575038 0.147475535530265 no 2888 0.155361788869743 4153 2233435
SGTC_2744 captopril 92.04 µM -1.01377907942383 0.147458250700076 no 2889 0.155344090022641 4133 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_155 k072-0202 43.6 µM -1.01447779296861 0.147295472853711 no 2890 0.155177410311108 4017 5857737
SGTC_376 3970-0862 59.1 µM -1.01455129365221 0.147278356555262 no 2891 0.155159883420733 4149 3135186
SGTC_1974 st069448 26.9 µM -1.01668883294715 0.146781165245702 no 2892 0.154650739870644 4087 6323587 YNR016C ACC1
SGTC_2863 9028737 58.44 µM -1.01715728183253 0.146672354712833 no 2893 0.154539307016136 4074 6460917
SGTC_3139 9095020 49.47 µM -1.01910456608109 0.146220623000578 no 2894 0.154076663334717 3798 25236292
SGTC_559 1550-0661 158 µM -1.02017493675681 0.145972716394996 no 2895 0.153822750979133 4168 5830875
SGTC_2986 9022445 71.43 µM -1.02164734173664 0.145632157051036 no 2896 0.153473921195547 4131 6459286
SGTC_3354 9151612 71.43 µM -1.02364420871341 0.14517114662656 no 2897 0.153001678044587 4138 27261949
SGTC_2750 bromebric acid 70.15 µM -1.02379858456293 0.145135547298893 no 2898 0.152965209542621 4163 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1608 st001473 40.5 µM -1.02420963825645 0.145040786283632 no 2899 0.152868133646754 4080 7292267
SGTC_2771 fluoxetine 41.05 µM -1.02668124743081 0.144471879525646 no 2900 0.15228529114011 4140 3386 A selective serotonin reuptake inhibitor.
SGTC_722 3534-0461 190 µM -1.02742994179529 0.144299844678743 no 2901 0.152109029283142 4173 658262
SGTC_1691 st019933 84.6 µM -1.02868915122243 0.144010815310641 no 2902 0.151812884751058 4105 6176082
SGTC_252 miconazole 1.30953 nM -1.03085106041213 0.143515498251921 no 2903 0.15130533474633 4021 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM -1.03109172074763 0.143460431554925 no 2904 0.151248904967876 4085 688761
SGTC_1686 st019653 115.5 µM -1.03137701860045 0.14339516960484 no 2905 0.151182026769078 4098 97252
SGTC_1192 1488-0095 21.4 µM -1.03148998573621 0.143369333887261 no 2906 0.151155550975264 4178 915875
SGTC_866 0495-0101 262 µM -1.03182319883548 0.143293145966934 no 2907 0.151077474716312 4103 635694
SGTC_1822 st052468 42 µM -1.03184238983596 0.143288758849815 no 2908 0.15107297882718 4129 2873678
SGTC_1705 st027868 56.3335 µM -1.03477253535752 0.14261998339567 no 2909 0.150387576022317 4071 292948
SGTC_1289 0976-0073 69.1 µM -1.0357570382953 0.14239575524067 no 2910 0.15015775249029 4184 3391136
SGTC_983 1491-0821 12.2 µM -1.03579944095228 0.142386103067541 no 2911 0.150147859225406 4123 46495113
SGTC_550 4123-0385 25.7 µM -1.03770900893163 0.141951884321329 no 2912 0.149702774738065 4156 5731123
SGTC_2557 derrustone 83.84 µM -1.03853915678355 0.141763395975782 no 2913 0.149509557627262 4130 629853 An antioxidant.
SGTC_420 mitomycin C 81.9 mM -1.04134804123928 0.141126885204158 no 2914 0.148857023890517 4119 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1262 0737-0114 49.6 µM -1.04187293060586 0.141008157229434 no 2915 0.14873529787124 4204 765919
SGTC_1312 1218-2183 165 µM -1.04397962740145 0.140532312175284 no 2916 0.148247407675713 4177 6744073
SGTC_989 1501-0895 10.3 µM -1.04575033526394 0.140133201897776 no 2917 0.147838158283101 4107 2830112
SGTC_1234 0326-0494 15.5 µM -1.04597346200444 0.140082964729786 no 2918 0.147786642518759 4219 1547813
SGTC_2896 9052656 71.43 µM -1.04679245354474 0.13989867300702 no 2919 0.147597655831124 3963 6469436
SGTC_51 1013-0126 23.419 µM -1.04837707024883 0.139542566239967 no 2920 0.147232456838498 4125 1627850
SGTC_104 0074-0074 590.992 µM -1.04923725738197 0.139349517008905 no 2921 0.147034467496947 3921 3943124
SGTC_2080 5212524 12.4 µM -1.05031280027051 0.139108391869994 no 2922 0.146787160988594 4028 260183
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -1.05034291277929 0.139101645058948 no 2923 0.146780241043584 4173 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_987 1497-1013 404 µM -1.05302527013119 0.138501547136256 no 2924 0.146164705260669 4138 1676435
SGTC_1282 0886-0010 32.4 µM -1.05855023706275 0.13727106533469 no 2925 0.144902330112814 4206 2836211 YNL267W PIK1
SGTC_2428 5615643 7.78 µM -1.05907505728967 0.137154570575969 no 2926 0.144782799186403 4194 2253075
SGTC_649 1123-0311 367 µM -1.0596650735093 0.137023684874773 no 2927 0.144648498793611 4045 693629 YIL048W NEO1
SGTC_685 1278-0033 54.9 µM -1.06001931957441 0.136945142043925 no 2928 0.144567905092417 4229 3590572
SGTC_3018 9082602 49.47 µM -1.06160519275816 0.136593902175926 no 2929 0.144207477675036 4105 17332089
SGTC_3065 9113888 49.47 µM -1.06259961844613 0.136373970879609 no 2930 0.143981780067274 4228 16648368
SGTC_1575 cyproterone acetate 48 µM -1.06293137154416 0.136300652913732 no 2931 0.143906537492074 4157 9880 An androgen receptor antagonist and liver toxin.
SGTC_2946 9065502 71.43 µM -1.06348387933087 0.136178607677914 no 2932 0.14378128598556 3968 16489101
SGTC_2594 a-mangostin 100 µM -1.06570414674253 0.135688919877179 no 2933 0.143278701271356 4198 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1212 0520-0165 585 µM -1.06594208226523 0.135636514006204 no 2934 0.143224912123433 4305 5403258
SGTC_809 3998-0021 90 µM -1.06792817862569 0.135199612433172 no 2935 0.142776455228919 4118 715485
SGTC_907 3448-6986 75.5 µM -1.06892166494517 0.13498142769353 no 2936 0.142552484390501 4203 590582
SGTC_2468 5987765 72.9 µM -1.07295772233967 0.134097532183074 no 2937 0.141645042751155 4204 26772094
SGTC_3259 9138485 49.47 µM -1.07373758475597 0.133927201960139 no 2938 0.141470155516518 4168 17646153
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -1.07474102581715 0.133708258604831 no 2939 0.141245345232586 4246 4213774
SGTC_2766 oltipraz 83.91 µM -1.07642787297713 0.133340755926917 no 2940 0.140867971129525 4144 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3060 1327-0027 12.5 µM -1.07769325197793 0.13306553240668 no 2941 0.140585335451492 4069 16000455 YPR107C YTH1
SGTC_171 k064-0041 9.68 µM -1.07867971487848 0.132851245342021 no 2942 0.140365265788878 4186 53325
SGTC_1474 0330-0125 5.35 µM -1.08033597776794 0.132491993819754 no 2943 0.139996297035016 4186 X1474
SGTC_1889 st059080 5.18 µM -1.0813933141894 0.132263002751781 no 2944 0.139761097203913 4140 176925 Isolated from Daphnopsis sellowiana.
SGTC_106 0092-0003 11.579 µM -1.08149747512291 0.132240459022888 no 2945 0.139737941606579 4091 1072148
SGTC_2974 9094440 9.66 µM -1.08264743103473 0.13199174814579 no 2946 0.139482472889928 4192 25236134
SGTC_37 0566-0070 1.56 µM -1.08470981264704 0.13154650761847 no 2947 0.139025100216539 4131 1626686
SGTC_4 0960-0234 25.671 µM -1.0876900065137 0.130904956870821 no 2948 0.138365990477073 4193 6821112
SGTC_378 3970-0959 8.33 µM -1.08793691339716 0.130851902015761 no 2949 0.138311479413579 4208 6615653
SGTC_2145 5634607 200 µM -1.08849903689464 0.130731169483784 no 2950 0.138187430759449 4145 308662
SGTC_3058 9093861 49.47 µM -1.08915691765186 0.130589968093251 no 2951 0.138042346890323 4194 17217477
SGTC_1967 st070177 51.4 µM -1.0898132510175 0.130449203936837 no 2952 0.137897707824954 4224 5729214
SGTC_676 falcarinol 140 µM -1.09054314126244 0.130292787280767 no 2953 0.137736980162566 4220 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_878 0828-0289 13.7 µM -1.09263647122369 0.129844903195453 no 2954 0.137276721468805 4124 745350 YLR208W SEC13
SGTC_313 3474-0040 5.03 µM -1.09276155312695 0.129818174750598 no 2955 0.137249253112834 4183 1043375 YIL048W NEO1
SGTC_544 k015-0020 52.4 µM -1.09500490001285 0.129339446286873 no 2956 0.136757244891419 4196 3008304
SGTC_2759 disulfiram 3.38 µM -1.09642346916908 0.129037356943099 no 2957 0.136446748989616 4092 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_2932 9016711 44.54 µM -1.09932288792515 0.128421438245926 no 2958 0.135813626222915 4206 7117328
SGTC_2551 apiole 73.87 µM -1.10283010814675 0.1276791365764 no 2959 0.135050475240702 4097 10659 A possible DNA adduct former.
SGTC_1062 mesoridazine 14.2 µM -1.10432394634747 0.127363873851048 no 2960 0.134726319390278 4221 4078 A neuroleptic.
SGTC_1605 st000082 49.1 µM -1.10546697855448 0.127123011879503 no 2961 0.134478647628485 4160 1114022
SGTC_1351 1496-0003 46.5 µM -1.10571420421172 0.12707095772592 no 2962 0.134425120012835 4221 3891978
SGTC_1434 4073-0095 163 µM -1.10607378383364 0.126995273565089 no 2963 0.134347292396244 4154 24133745
SGTC_1438 4092-1045 4 µM -1.10657341797972 0.126890162882529 no 2964 0.134239202674738 4217 1351342
SGTC_1084 voriconazole 435 nM -1.10924831272957 0.126328461189836 no 2965 0.133661537970123 4204 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2195 6536160 144.242 µM -1.11269276498399 0.125607715328622 no 2966 0.132920201952913 4178 3834386
SGTC_1400 3771-8998 51.5 µM -1.11331964092498 0.125476851815711 no 2967 0.132785586969836 4112 670767
SGTC_253 dyclonine 31.25 µM -1.11748655388921 0.124609406079686 no 2968 0.131893172789228 4308 3180 An oral anasthetic.
SGTC_1500 4488-1866 171 µM -1.12123176223613 0.123833333178859 no 2969 0.131094611532049 4277 2900003
SGTC_2363 9053361 176 µM -1.12194925534776 0.123685043028486 no 2970 0.130942008164763 4284 6469797 YMR079W SEC14
SGTC_625 k213-0058 121 µM -1.12243550217046 0.123584617145477 no 2971 0.13083865830156 4275 3655420
SGTC_1101 ebselen 5.29 µM -1.12425966466997 0.123208376895058 no 2972 0.130451442229551 4255 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_107 0358-0022 2.6945 µM -1.12610379698278 0.122828834470886 no 2973 0.130060793527658 4231 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2682 pyrogallin 40.03 µM -1.13042145853274 0.121943422125068 no 2974 0.129149338160064 4222 822798 An ATP competetive kinase inhibitor.
SGTC_2526 patulin 37.61 µM -1.13168610206783 0.121684935685541 no 2975 0.128883213264856 4248 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_1288 0973-0013 65.5 µM -1.13428477397328 0.121154989998289 no 2976 0.128337556941514 4255 4315430
SGTC_3091 9116372 49.47 µM -1.13648376602142 0.120707820557527 no 2977 0.127877077975064 4290 17169793
SGTC_2426 5582046 32.21 µM -1.1367686768113 0.120649968506289 no 2978 0.127817500474382 4246 2251934
SGTC_1913 st060213 96.1 µM -1.1379293883487 0.120414484063481 no 2979 0.127574984262156 4260 688959
SGTC_1392 3455-1037 33.9 µM -1.13911545216346 0.120174190762346 no 2980 0.127327501676569 4226 981132
SGTC_2621 lithochol-11-enic acid 100 µM -1.13971945283141 0.12005195180052 no 2981 0.127201600068997 4187 6708711
SGTC_1742 st038235 28.8875 µM -1.14499009689457 0.118988985478588 no 2982 0.126106629842832 4286 564103 YBR002C RER2
SGTC_1662 st014054 52 µM -1.14648160851243 0.118689392384978 no 2983 0.125797966379794 4276 2838777
SGTC_1391 3442-0225 151 µM -1.14796318515056 0.118392322897337 no 2984 0.125491881031952 4210 5227075
SGTC_827 3253-0474 693 µM -1.14816349067628 0.118352200200283 no 2985 0.125450538963715 4266 5402065
SGTC_1758 st042942 75.2445 µM -1.1488995859734 0.118204837370954 no 2986 0.125298694198597 4212 669317
SGTC_2027 5150920 200 µM -1.1500543807039 0.117973914396276 no 2987 0.125060737028076 4190 786715
SGTC_1816 st051957 91.6 µM -1.15071801635032 0.117841352426995 no 2988 0.12492413107269 4231 674121
SGTC_2490 carminic acid 95.39 µM -1.15104201310491 0.117776672012766 no 2989 0.124857475906016 4211 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_2835 9006588 71.43 µM -1.15126215536052 0.117732738710914 no 2990 0.124812200686117 4302 2345538
SGTC_1276 0871-0068 94.2 µM -1.15171701821451 0.1176419994827 no 2991 0.124718688357069 4243 3414906
SGTC_1255 0566-0045 221 µM -1.15216827191727 0.117552029158793 no 2992 0.124625966404647 4251 2788469
SGTC_1367 1812-0510 76.9 µM -1.15240056315543 0.117505734257333 no 2993 0.124578254845467 4277 1142582 YDR527W RBA50
SGTC_781 4335-2806 94.4 µM -1.15285293454432 0.117415615135071 no 2994 0.124485376478243 4301 845254
SGTC_163 TUB2.036 7.546 µM -1.15428923624224 0.117129806854406 no 2995 0.124190803966013 4215 15992207 YJR013W GPI14
SGTC_699 0375-0592 111 µM -1.16175316304949 0.115652503223691 no 2996 0.122667872054111 4325 762578
SGTC_935 2996-0153 430 µM -1.16362576192804 0.115283953530102 no 2997 0.122287853284679 4250 23738523
SGTC_2341 7987486 176.74 µM -1.16448713063798 0.115114706556845 no 2998 0.122113327861953 4285 1258686
SGTC_466 geldanamycin 89.2 µM -1.16458545623958 0.115095398183775 no 2999 0.122093416838626 4227 5288382 HSP90 inhibitor.
SGTC_2520 obtusaquinone 4.71 µM -1.16711631775572 0.114599200696861 no 3000 0.121581699468436 4302 5967872
SGTC_2724 maprotiline 69.64 µM -1.16959582844161 0.114114549250091 no 3001 0.121081828441434 4198 4011 A tricyclic antidepressant.
SGTC_468 gf-109203x 121 µM -1.17002993162576 0.114029848739448 no 3002 0.120994461878015 4263 2396 A protein kinase C inhibitor.
SGTC_1524 corynanthine 62.1 µM -1.17068300596829 0.113902507824353 no 3003 0.120863109277827 4358 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_2649 anisomycin 9.56 µM -1.17274026390226 0.113502032022793 no 3004 0.120449989847006 4298 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_1922 5578187 25 µM -1.17281027160978 0.113488421670477 no 3005 0.120435949067801 4286 1350412
SGTC_1239 0337-0584 35.4 µM -1.17593617618315 0.112881893387399 no 3006 0.119810190657595 4326 914301 YML130C ERO1
SGTC_3281 9140613 49.47 µM -1.17624648680232 0.112821809420579 no 3007 0.119748196518401 4269 16013766
SGTC_2300 7976697 71.57 µM -1.17637447654536 0.112797034028401 no 3008 0.119722633200724 4156 2236109
SGTC_2704 st078022 71.1 µM -1.17733343718141 0.112611528465918 no 3009 0.119531222977433 4303 54697681
SGTC_3253 9135987 49.47 µM -1.17860682092594 0.112365536423962 no 3010 0.11927738715679 4262 4182430
SGTC_1875 nocodazole 6 µM -1.18001925983419 0.112093131129229 no 3011 0.118996277428017 4288 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_3341 9147222 25.867 µM -1.18016967927648 0.112064148826295 no 3012 0.118966367882953 4271 1939759
SGTC_586 0957-0265 8.15 µM -1.18192613009708 0.111726118348449 no 3013 0.118617506411398 4132 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_2457 5731572 11.68 µM -1.18545066550496 0.11105002004037 no 3014 0.117919654813116 4321 2865357
SGTC_1023 4482-3888 16 µM -1.18547766519729 0.111044852125399 no 3015 0.117914320157696 4296 3303168
SGTC_503 tyrphostin 8 294 µM -1.18585009389755 0.11097358444753 no 3016 0.117840752340606 4276 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1656 st012921 11 µM -1.18722596472355 0.110710582930722 no 3017 0.117569250915304 4167 6732821
SGTC_2919 7978188 46.38 µM -1.18823850992434 0.110517317631013 no 3018 0.117369727820851 4296 2980291
SGTC_1073 triclabendazole 3.09 µM -1.18853472692778 0.110460824211468 no 3019 0.117311403312039 4316 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2 0422-0095 29 µM -1.18885600776032 0.110399574118924 no 3020 0.117248166997151 4176 6790840
SGTC_2123 5259487 200 µM -1.18890708934295 0.110389837992899 no 3021 0.117238115055523 4298 2173474
SGTC_189 3970-0742 2.116 µM -1.19065018987325 0.110057972710005 no 3022 0.116895469812777 4249 2891807
SGTC_2190 6049624 200 µM -1.19098033539588 0.10999519769877 no 3023 0.116830652385365 4164 2265554
SGTC_381 3461-2219 42.7 µM -1.19103992087711 0.109983870646728 no 3024 0.116818956690134 4276 2883159
SGTC_1874 staurosporine 7.6 µM -1.19160343668798 0.109876789074787 no 3025 0.116708388416334 4291 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_593 1203-0218 61.7 µM -1.19262395242985 0.109683056996636 no 3026 0.116508340411391 4309 3666956
SGTC_354 2783-3500 4.88 µM -1.19276125404504 0.109657010739679 no 3027 0.116481444246135 4289 6740761
SGTC_501 nsc-95397 161 µM -1.19488164795321 0.109255333552147 no 3028 0.116066637029461 4310 262093
SGTC_1013 4112-3890 241 µM -1.19492403747211 0.109247314278322 no 3029 0.116058355180889 4227 705171
SGTC_2348 9022543 33.42 µM -1.19510179240289 0.109213691102075 no 3030 0.116023630894356 4307 3162678 YDL140C RPO21
SGTC_604 1000-0114 314 µM -1.19567438381231 0.109105433312853 no 3031 0.115911825755784 4289 1572745
SGTC_1382 3002-2117 298 µM -1.20121218818084 0.108062398603767 no 3032 0.114834451357792 4353 1497314
SGTC_3211 9128781 49.47 µM -1.2012428598411 0.108056641716761 no 3033 0.114828504120481 4263 17194361
SGTC_1895 st058434 18.3 µM -1.20272122994786 0.107779422266429 no 3034 0.114542107805057 4301 5393175
SGTC_1424 4048-1941 275 µM -1.2048002697285 0.107390434438952 no 3035 0.114140207926846 4359 X1424
SGTC_222 nsc-310342 10.666 µM -1.2051351962864 0.107327864526416 no 3036 0.114075557214235 4306 432556
SGTC_1821 st053465 65.6 µM -1.20608990898922 0.107149652381133 no 3037 0.113891412648778 4305 675086
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -1.2079095373325 0.106810581264062 no 3038 0.113541030323511 4239 2333 A French combination drug.
SGTC_568 1193-0097 7.48 µM -1.2080417981807 0.106785965880104 no 3039 0.113515592556611 4103 3646150
SGTC_3073 9114972 49.47 µM -1.20916043484246 0.106577937435264 no 3040 0.113300607371792 4291 41905075
SGTC_133 0724-0033 378.92 µM -1.21029245449798 0.106367718178045 no 3041 0.113083346006262 4122 280309
SGTC_3230 9131665 49.47 µM -1.21053229275361 0.106323218000384 no 3042 0.113037353559966 4267 15943720
SGTC_1682 st012968 530 nM -1.21130740161572 0.106179494344985 no 3043 0.112888806542057 4303 24207270
SGTC_3225 9130819 49.47 µM -1.21157191118307 0.106130480099664 no 3044 0.11283814607471 4245 4547121
SGTC_2049 5262831 67.185 µM -1.2127844056705 0.105906011207383 no 3045 0.112606129542648 4276 763417
SGTC_2823 7987624 58.44 µM -1.21351554430775 0.1057708215784 no 3046 0.112466387503926 4290 2239440
SGTC_3038 9091290 49.47 µM -1.21477605980827 0.105538041663148 no 3047 0.112225757012203 4316 25236843
SGTC_1899 st063254 59.6 µM -1.21876025978273 0.104804714463889 no 3048 0.111467599458061 4240 3093813
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM -1.22349038698545 0.103938891991931 no 3049 0.110572266409064 4352 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_1043 0916-0009 19.3 µM -1.2242601982525 0.103798474713805 no 3050 0.110427043264106 4344 3101130
SGTC_608 k048-0125 159 µM -1.22556155512744 0.103561413981692 no 3051 0.11018185632821 4348 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_912 3474-0017 2.18 µM -1.23482750568111 0.101884839847675 no 3052 0.10844735411627 4347 3360550
SGTC_1306 1185-0270 9.02 µM -1.23769943558303 0.101369227369658 no 3053 0.107913764258939 4341 1548076
SGTC_2620 irigenin 100 µM -1.23949987093976 0.101046956759133 no 3054 0.10758021826527 4343 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_1703 st026983 48.3 µM -1.24069311435579 0.100833782917654 no 3055 0.10735956946877 4349 1104023
SGTC_152 4469-0003 551.229 µM -1.24146421651489 0.100696199471884 no 3056 0.107217154626903 4297 697280
SGTC_2357 9067248 200 µM -1.24584897722257 0.0999164534076444 no 3057 0.106409922416647 4292 9150235
SGTC_3195 9113082 49.47 µM -1.24702337177737 0.099708360432759 no 3058 0.106194463995131 4330 17018038
SGTC_942 3253-1115 227 µM -1.24703690027453 0.0997059651414342 no 3059 0.106191983848341 4346 46497897
SGTC_1594 piperine 70.1 µM -1.24739619802975 0.0996423649752166 no 3060 0.10612612996783 4308 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_3303 9125618 40.5795 µM -1.24823004010062 0.0994948788065919 no 3061 0.105973412940584 4342 22695467
SGTC_2743 auranofin 4.32 µM -1.24925766827214 0.0993133362021256 no 3062 0.105785422791221 4347 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_3063 1327-0034 4 µM -1.25026598029474 0.0991354415347503 no 3063 0.10560120068497 4211 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_2639 lactacystin 53 µM -1.25051907358467 0.0990908253547152 no 3064 0.105554996106778 4353 3870 A proteasome inhibitor.
SGTC_221 trifluoperazine 10.304 µM -1.25149853466669 0.0989183008834885 no 3065 0.105376323971562 4298 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1841 st054148 70 µM -1.25372322807458 0.0985272550578177 no 3066 0.10497131105272 4355 675442
SGTC_2395 5646831 180.19 µM -1.25541605736097 0.0982304568565548 no 3067 0.104663881617119 4333 6808628
SGTC_1791 st048313 56.1 µM -1.25649882799741 0.0980409619561263 no 3068 0.104467585291034 4340 1204976
SGTC_553 k007-0256 45.7 µM -1.25702701753922 0.0979486211495875 no 3069 0.10437192625593 4381 6287000
SGTC_3103 9120822 49.47 µM -1.2577053585839 0.0978301236001317 no 3070 0.104249166800987 4334 17141819
SGTC_1038 k292-0204 154 µM -1.25813338779542 0.0977554064355096 no 3071 0.10417176017833 4275 4454212
SGTC_479 n-linoleoylglycine 10 µM -1.26002429451751 0.0974258286576281 no 3072 0.103830299157987 4376 6433346 An anti-infammatory.
SGTC_1983 st071813 46.9 µM -1.26037859216779 0.0973641667105058 no 3073 0.103766410298016 4398 11838595
SGTC_2442 5158906 48.48 µM -1.26053268300192 0.0973373576841373 no 3074 0.103738632709676 4341 1893835
SGTC_1724 st037281 8.293 µM -1.26271568770356 0.0969581358923825 no 3075 0.103345687061676 4304 574124 YDL195W SEC31
SGTC_2073 5212005 126 µM -1.26587877747098 0.0964105841336306 no 3076 0.102778242773749 4220 691789
SGTC_616 4092-0450 108 µM -1.26871047541671 0.0959223291071888 no 3077 0.102272172456913 4345 787165
SGTC_25 0118-0223 35.662 µM -1.27213435851019 0.0953343984258791 no 3078 0.101662692660021 4349 5333628
SGTC_1725 st036284 20.55 µM -1.27235041042747 0.0952973883410228 no 3079 0.101624322508156 4389 707914
SGTC_1105 epirubicin 18.1 µM -1.2723654437335 0.0952948135021588 no 3080 0.10162165303199 4368 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_224 benfluorex 43.875 µM -1.27287680348339 0.0952072605428287 no 3081 0.101530880877908 4368 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_2443 5493264 126.67 µM -1.2733684443181 0.0951231396420041 no 3082 0.101443664746724 4386 5340055
SGTC_1799 st045822 46.1415 µM -1.27663881913844 0.0945649635671414 no 3083 0.100864895131962 4339 3674992
SGTC_1240 0356-0016 42.1 µM -1.27756713302201 0.0944069630580412 no 3084 0.100701047750141 4319 4305613
SGTC_383 2324-0395 7.37 µM -1.28021717233999 0.0939569932850545 no 3085 0.10023438406426 4343 3146421
SGTC_48 0382-0018 55 µM -1.28136771200511 0.0937621281461129 no 3086 0.100032269790838 4391 762596
SGTC_274 sirtinol 40.1 µM -1.28319732889222 0.0934528634552505 no 3087 0.0997114757826361 4406 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_524 r073-0010 27.8 µM -1.28321046612121 0.0934506455645019 no 3088 0.099709175100976 4275 2772106
SGTC_2492 derrusnin 100 µM -1.28438703124819 0.0932521697592269 no 3089 0.0995032841933668 4382 1715307 Part of coumarin class of compounds.
SGTC_1972 st070201 17.4 µM -1.28454160916361 0.0932261170403909 no 3090 0.0994762572181693 4366 2829099
SGTC_2502 avocadyne acetate 18.59 µM -1.28456237844825 0.0932226169739684 no 3091 0.0994726262484617 4292 3952079
SGTC_1308 1187-1617 41.4 µM -1.28484709447251 0.0931746460539212 no 3092 0.0994228608159645 4383 2882570
SGTC_27 0485-0001 32.618 µM -1.28523869676188 0.0931086960015067 no 3093 0.0993544424972655 4345 2054479
SGTC_1173 0443-0020 122 µM -1.28887105658556 0.0924986108226169 no 3094 0.0987214589025172 4355 5331295
SGTC_1229 0139-0193 12.2 µM -1.29108676133905 0.092127919858946 no 3095 0.0983367970609045 4432 3090752
SGTC_3298 9116858 71.43 µM -1.29335174050477 0.0917501231376456 no 3096 0.0979447165697611 4418 2506942
SGTC_3193 9111931 49.47 µM -1.29425852197136 0.0915991948596187 no 3097 0.0977880692180876 4354 17087244
SGTC_458 nppb 133 µM -1.29663763915417 0.0912040799144167 no 3098 0.0973779476889583 4421 4549 A chloride channel blocker.
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -1.299711606835 0.0906954399712778 no 3099 0.0968499153810661 4377 551469
SGTC_651 3253-0966 34.4 µM -1.30191396419509 0.09033231929053 no 3100 0.0964728991468212 4383 781462
SGTC_3307 9126885 69.2785 µM -1.30746682444788 0.0894215684478255 no 3101 0.0955271075066187 4335 24824909
SGTC_1059 3448-6867 171 µM -1.31014820615365 0.0889842354898831 no 3102 0.0950728516378716 4336 3934407
SGTC_1335 1486-0900 202 µM -1.32195376867018 0.0870776745905845 no 3103 0.0930917730517009 4376 X1335
SGTC_2872 9044037 25.97 µM -1.32526862375513 0.086547861760119 no 3104 0.0925410358770139 4429 6465195
SGTC_3031 9088762 49.47 µM -1.32569664683083 0.0864796269350268 no 3105 0.0924700992803275 4346 205253
SGTC_1509 1326-1131 80 µM -1.33100509572538 0.0856367014740523 no 3106 0.0915936671163603 4366 768313
SGTC_2014 4013930 200 µM -1.33148089620601 0.0855614508440172 no 3107 0.0915154134153982 4357 64556
SGTC_1113 artemisinin 1.17947 µM -1.33229923704283 0.0854321412875021 no 3108 0.0913809388825363 4426 2240 An anti-malaria and mitochondrial poison.
SGTC_1558 st069300 45.6 µM -1.33508431046795 0.0849931565671916 no 3109 0.090924376948972 4334 24208000
SGTC_2385 9074692 200 µM -1.33892428821773 0.0843906729037348 no 3110 0.0902976609074684 4401 17046906
SGTC_1676 st018489 23.4 µM -1.34024247302739 0.0841845933084526 no 3111 0.0900832636510624 4400 3696235
SGTC_1452 4194-0072 190 µM -1.34169115348568 0.0839585484972925 no 3112 0.0898480782998587 4454 1343545
SGTC_350 k064-0020 19.8 µM -1.34681009524341 0.0831634646124378 no 3113 0.0890207012747443 4423 2790705
SGTC_2379 9035213 200 µM -1.35574762543079 0.0817888628787364 no 3114 0.087589740309515 4406 646551
SGTC_780 0109-0199 192 µM -1.3577614010116 0.0814815195176018 no 3115 0.0872697032366542 4457 610414
SGTC_1794 st048918 76.9 µM -1.35981092420036 0.0811696154755309 no 3116 0.0869448822724062 4361 672303
SGTC_674 0498-0004 451 µM -1.36568515316018 0.0802806452151441 no 3117 0.0860189031576478 4401 4231473
SGTC_2077 5212015 200 µM -1.3656946546768 0.0802792132974594 no 3118 0.0860174113949481 4321 780900
SGTC_1876 myriocin 605 nM -1.3702130441658 0.0796004581325428 no 3119 0.0853102038058265 4406 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_1314 1222-0010 41.1 µM -1.37108848001391 0.0794694532444212 no 3120 0.085173687834545 4420 3526027
SGTC_105 0111-0055 734.78 µM -1.37511270522843 0.0788693449755518 no 3121 0.0845482530122294 4437 5179370
SGTC_961 1252-1571 372 µM -1.38224080625556 0.0778148100179771 no 3122 0.0834488872445571 4437 6813498
SGTC_1061 3448-9325 110 µM -1.38386880616802 0.0775754708897336 no 3123 0.083199314917322 4380 723482
SGTC_1963 st076565 50.3 µM -1.38877636607352 0.0768573717097325 no 3124 0.0824503820359431 4444 4914280
SGTC_2361 9034121 116 µM -1.39281383888363 0.0762703863592107 no 3125 0.081838046235221 4445 6496917
SGTC_2847 9005661 71.43 µM -1.39393839869793 0.0761075019729089 no 3126 0.0816681037641875 4471 2991449
SGTC_3137 9097352 49.47 µM -1.39505057026941 0.0759466725101011 no 3127 0.0815002951991836 4443 44120435
SGTC_294 k038-0071 157 µM -1.39760531270841 0.0755782151620213 no 3128 0.0811158110529701 4445 24152826
SGTC_2354 9060492 162 µM -1.39861309850351 0.0754332425994824 no 3129 0.0809645181439034 4457 6471895
SGTC_1800 st050079 29.0735 µM -1.39898566682183 0.0753797013854162 no 3130 0.0809086406300974 4248 3645560
SGTC_2371 9071574 200 µM -1.39933535759131 0.0753294742251769 no 3131 0.080856220763637 4442 45596039
SGTC_1574 spiramycin 23.7 µM -1.40372744144975 0.0747007962786031 no 3132 0.0802000138302762 4404 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_2163 5671233 125 µM -1.40468557201611 0.074564184046708 no 3133 0.0800573989850634 4397 701023
SGTC_1693 xanthone 101.9 µM -1.40594792891694 0.0743844858331379 no 3134 0.0798697937848641 4466 7020 An insecticide.
SGTC_569 4130-2812 160 µM -1.40775839226357 0.0741273413549465 no 3135 0.079601312347515 4306 743552
SGTC_653 0203-0016 55.2 µM -1.40879626602013 0.0739802361583045 no 3136 0.0794477097966835 4500 295302
SGTC_2204 7233102 200 µM -1.40888633732028 0.0739674802412946 no 3137 0.0794343900700616 4394 2172480
SGTC_110 0850-0284 111.64 µM -1.4101621711857 0.0737869768179283 no 3138 0.0792459014794164 4349 3906265
SGTC_2684 capsaicin 100 µM -1.41296931660097 0.0733910108185969 no 3139 0.0788323730573127 4457 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_1877 wortmannin 25 µM -1.41756529204095 0.0727462302860476 no 3140 0.0781588596696664 4473 312145 A covalent inhibitor of PI 3-kinase.
SGTC_2200 6600604 21.907 µM -1.41974704091279 0.0724416698033303 no 3141 0.0778406689096348 4475 2904777
SGTC_1855 st056195 39.6 µM -1.42479151051373 0.071741230088159 no 3142 0.0771087385307462 4369 4028379
SGTC_772 k072-0172 35.3 µM -1.425154894163 0.0716909744703757 no 3143 0.0770562157854259 4486 5861980
SGTC_75 0159-0059 199.013 µM -1.42884271658944 0.0711824787751572 no 3144 0.076524722431528 4517 5377270
SGTC_913 3487-1245 167 µM -1.43169276350579 0.0707914004318337 no 3145 0.0761158841608625 4391 4016153
SGTC_2078 5212016 200 µM -1.43244832213498 0.0706880013663124 no 3146 0.0760077788498662 4354 1899708
SGTC_1644 st010134 20.9 µM -1.43404422824236 0.0704699812967614 no 3147 0.075779820922618 4432 3818134
SGTC_2787 5284540 71.43 µM -1.4345548947538 0.0704003273582767 no 3148 0.075706987815502 4464 736958
SGTC_2225 6654152 15.4 µM -1.43593026301034 0.0702129930171783 no 3149 0.075511093027853 4396 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_2453 5731132 22.18 µM -1.43636143172656 0.0701543439632226 no 3150 0.0754497609196358 4481 1362040
SGTC_1033 k072-0102 21.3 µM -1.43740339318207 0.0700127683443603 no 3151 0.075301702605276 4419 5965931
SGTC_1451 4152-0210 104 µM -1.43983023427854 0.0696838756899512 no 3152 0.0749577175228972 4496 659563
SGTC_1364 1653-0028 37.6 µM -1.44779782316485 0.0686124435951604 no 3153 0.0738368008771818 4463 5718652
SGTC_2493 resveratrol 26.09 µM -1.4487134178981 0.0684901384727432 no 3154 0.0737088158643571 4407 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2999 9069765 71.4286 µM -1.44893136082573 0.0684610504581746 no 3155 0.0736783760467933 4412 2097066
SGTC_26 0302-0163 425.158 µM -1.4567165651105 0.0674282272476831 no 3156 0.0725973176224154 4523 3100915
SGTC_324 1315-0088 19.6 µM -1.45915639309824 0.0671070384053785 no 3157 0.0722610339131828 4430 6787421
SGTC_216 k038-0035 28.382 µM -1.46082152733346 0.0668885135448764 no 3158 0.0720322132111178 4406 4444231 YPR107C YTH1
SGTC_1853 st056710 91.2 µM -1.46108333597163 0.0668542050745466 no 3159 0.0719962863831162 4507 269167
SGTC_258 haloperidol 50.781 µM -1.46267108484238 0.0666464315644489 no 3160 0.0717787009466938 4472 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2757 clomiphene 4.22 µM -1.46272207521273 0.0666397672343059 no 3161 0.0717717215838989 4479 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2131 toluylene red 5.2905 µM -1.47087671821432 0.0655805950000743 no 3162 0.0706622299968686 4431 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_2212 7123476 200 µM -1.4736137465401 0.0652280348517318 no 3163 0.0702928090108365 4506 1085715
SGTC_3112 9123419 49.47 µM -1.47540639009365 0.0649979203009775 no 3164 0.0700516592130045 4529 17015854
SGTC_2693 st077581 40.7 µM -1.47688015599111 0.0648092111890095 no 3165 0.0698538825694511 4455 25238761
SGTC_671 0560-0003 407 µM -1.48145462441263 0.0642261798311225 no 3166 0.0692427339328256 4432 3238678
SGTC_3250 9135583 49.47 µM -1.48897157210318 0.0632769833622489 no 3167 0.0682474273884454 4500 7699353
SGTC_669 0108-0021 26.2 µM -1.49406099162855 0.0626405465428221 no 3168 0.0675798392395583 4495 17201
SGTC_969 1313-0238 134 µM -1.49603689011425 0.0623948073213521 no 3169 0.067322021086506 4525 5212874
SGTC_1845 st056753 3.01 µM -1.49628221661822 0.0623643490047059 no 3170 0.0672900636548028 4457 5375839
SGTC_2349 9023730 187.07 µM -1.49630425071519 0.062361613946507 no 3171 0.067287193959488 4522 4126287
SGTC_2432 5630864 12.22 µM -1.49765157241961 0.0621945506599872 no 3172 0.0671119000400023 4493 5714970
SGTC_1398 3558-0053 112 µM -1.50054242568566 0.0618372730445759 no 3173 0.0667369761744634 4464 4532369
SGTC_500 h-89 112 µM -1.50184623726814 0.0616766614021148 no 3174 0.0665684119914702 4458 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_562 3772-2733 112 µM -1.50286115684342 0.0615518628779615 no 3175 0.0664374256757775 4483 2876874 YIL048W NEO1
SGTC_276 colchicine 750 µM -1.50654063782091 0.0611010722141098 no 3176 0.0659642215896463 4524 2833 A microtubule depolymerizer.
SGTC_843 0310-0051 143 µM -1.50663805495577 0.0610891723360713 no 3177 0.0659517287224674 4519 2065037
SGTC_754 3474-0146 171 µM -1.51129193170926 0.0605227908403018 no 3178 0.0653570443458705 4495 24762078
SGTC_896 0964-0007 44.5 µM -1.51425163152173 0.060164735036212 no 3179 0.0649810155095003 4454 6756758
SGTC_526 4469-0568 170 µM -1.51921142655764 0.0595684341138888 no 3180 0.0643546430172851 4468 2901964
SGTC_1941 st076221 61.8 µM -1.52473400285441 0.0589099324202458 no 3181 0.0636627284998152 4390 2828568
SGTC_1196 1588-0294 184 µM -1.52952741757743 0.0583430170076058 no 3182 0.0630668737307436 4545 6144269
SGTC_944 3370-0224 231 µM -1.53192104957167 0.0580615317097339 no 3183 0.062770959218661 4493 4580514
SGTC_609 0986-0026 86.3 µM -1.53240589532195 0.0580046452210696 no 3184 0.0627111517930981 4498 2848610
SGTC_2589 lobaric acid 100 µM -1.54156275810106 0.0569384840414068 no 3185 0.0615899406882996 4454 73157 A novel microtubule depolymerizer.
SGTC_999 SEC7.066 22.7 µM -1.54262181241588 0.0568161771929635 no 3186 0.0614612812556687 4467 740511 YDR170C SEC7
SGTC_2856 9022925 19.48 µM -1.56169156479941 0.0546490902349521 no 3187 0.0591803334505284 4530 4944862
SGTC_2254 7938975 95.19 µM -1.56204746570149 0.0546092757763574 no 3188 0.0591384037000519 4559 2969277
SGTC_1347 1493-0251 600 nM -1.56449402575104 0.0543362007551486 no 3189 0.0588507974463145 4569 3986378
SGTC_1591 genipin 88.4 µM -1.56558073222761 0.0542152540335194 no 3190 0.0587234018267531 4531 442424 A DNA cross-linking agent.
SGTC_743 1275-0778 158 µM -1.57153662697055 0.0535561621902903 no 3191 0.0580290268125833 4506 2849257 YMR203W TOM40
SGTC_1210 3013-0140 750 nM -1.57166079913493 0.0535424888927894 no 3192 0.0580146190196614 4550 905973
SGTC_1346 1488-2224 62.4 µM -1.57377105251321 0.0533105396246683 no 3193 0.0577701943034679 4546 3722427
SGTC_1944 st076371 56.9 µM -1.57686892720444 0.0529714791648188 no 3194 0.0574128438023767 4486 24208455
SGTC_212 3807-4682 38.772 µM -1.57994227558247 0.0526367953509958 no 3195 0.0570600432620776 4606 3125501 YBL034C STU1
SGTC_2495 cafestol 54.53 µM -1.58350333221685 0.0522511017772137 no 3196 0.056653393884757 4523 16667697 An anti-infammatory.
SGTC_3218 9131285 49.47 µM -1.58398592778977 0.052199005585237 no 3197 0.0565984607378748 4521 17156417
SGTC_312 4092-0653 6.84 µM -1.58859122063895 0.0517039368961633 no 3198 0.0560763557850007 4426 1148278
SGTC_1883 5-benzylidenerhodanine 20 µM -1.58936234828257 0.0516214067293421 no 3199 0.055989304989067 4525 1273210
SGTC_635 k038-0028 24.7 µM -1.59015013157888 0.051537202174987 no 3200 0.0559004840784273 4555 4035102
SGTC_716 1683-5115 658 µM -1.59122741975806 0.0514222298759672 no 3201 0.0557792020838905 4540 723597
SGTC_456 gingerol 170 µM -1.59155104510124 0.0513877312202927 no 3202 0.0557428086588551 4553 442793 A herb.
SGTC_493 zm226600 134 µM -1.59374499351181 0.0511543401900736 no 3203 0.0554965811244742 4550 5240098 A potassium channel opener. YCR052W RSC6
SGTC_1993 st073995 70.8 µM -1.59631214925071 0.0508823193348344 no 3204 0.0552095594689552 4544 3098394
SGTC_180 1486-1293 102.781 µM -1.59898145342332 0.0506006971705241 no 3205 0.0549123618251877 4467 4140536
SGTC_1815 st051655 58.2 µM -1.60470745934752 0.050000769436988 no 3206 0.054279099789406 4506 5984156
SGTC_427 1354-0053 47.3 µM -1.61314625990246 0.0491269698262056 no 3207 0.0533563677994089 4568 6813657
SGTC_2081 5214970 32.255 µM -1.61499263085333 0.0489374222246961 no 3208 0.053156145358931 4491 2063512
SGTC_1429 4049-0205 9.46 µM -1.61933068680962 0.0484943783681267 no 3209 0.0526880657395601 4610 22774478
SGTC_1360 1598-0022 39.8 µM -1.62059881401926 0.0483654726700951 no 3210 0.0525518533803956 4573 761525
SGTC_2375 9072683 200 µM -1.62242406854837 0.048180416013779 no 3211 0.05235628956646 4590 16798029
SGTC_1005 4092-0690 4.4 µM -1.63436413488537 0.0469837860042275 no 3212 0.0510912071562044 4568 1529343
SGTC_2165 5727197 32.143 µM -1.63475217408738 0.0469453003445097 no 3213 0.0510505051384418 4590 1361712
SGTC_1204 4049-0315 18.3 µM -1.63614918641295 0.0468069542137145 no 3214 0.0509041840677798 4571 588402
SGTC_446 go6976 132 µM -1.63772295050709 0.0466514962855293 no 3215 0.0507397503865832 4567 3501 A protein kinase C inhibitor.
SGTC_1317 1273-0028 910 nM -1.64090959657914 0.0463379851544756 no 3216 0.0504080913267682 4583 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_707 0865-0008 204 µM -1.64175414895306 0.0462551799170366 no 3217 0.0503204823812211 4620 723043
SGTC_115 0527-0192 112.043 µM -1.64596607482121 0.0458439885181153 no 3218 0.0498853719062477 4541 4233931
SGTC_2761 levamisole 97.89 µM -1.64814006315026 0.0456329040592314 no 3219 0.0496619663858162 4574 26879 An alkaline phosphatase inhibitor.
SGTC_2229 7354935 190 µM -1.65270592215571 0.0451921235607854 no 3220 0.0491953642745976 4560 318112
SGTC_3001 9076041 71.4286 µM -1.65570122014776 0.044904827839295 no 3221 0.0488911700510628 4569 16004211
SGTC_2722 naftopidil 47.16 µM -1.65616938247109 0.0448600569362018 no 3222 0.0488437608795343 4509 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_812 4251-0442 148 µM -1.65646557125623 0.0448317506262092 no 3223 0.0488137858489944 4592 5723007
SGTC_2223 6903751 107.57 µM -1.65726281623835 0.044755630585173 no 3224 0.0487331757413523 4545 5598863
SGTC_873 0591-4978 488 µM -1.65781807554822 0.0447026765709663 no 3225 0.0486770958921374 4585 3305145
SGTC_2179 6298986 200 µM -1.66479063890981 0.0440420023393271 no 3226 0.0479772660974671 4535 738374
SGTC_101 0490-5701 117.494 µM -1.66659842953443 0.0438719995146643 no 3227 0.0477971406934951 4450 4661669
SGTC_1384 3089-0840 101 µM -1.66995711691758 0.0435575573609555 no 3228 0.0474639241839675 4569 1069836
SGTC_1827 berberine 7.24 µM -1.67226513672166 0.0433425355950266 no 3229 0.0472360255655954 4486 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2966 9084041 48.03 µM -1.67454966450243 0.0431305472258723 no 3230 0.0470113111536932 4525 17741380
SGTC_620 0109-0052 432 µM -1.67492692033034 0.0430956211999106 no 3231 0.0469742855061483 4625 493037
SGTC_2595 hexamethylquercetagetin 100 µM -1.67740207569821 0.0428670397115207 no 3232 0.0467319418793499 4553 386331
SGTC_839 0122-0028 230 µM -1.67753450779399 0.0428548372275125 no 3233 0.0467190037131613 4593 759448
SGTC_2816 7982706 58.44 µM -1.68017116749263 0.0426124753998275 no 3234 0.0464620086956258 4557 2981853
SGTC_2198 6589944 200 µM -1.68770134852745 0.0419263983117684 no 3235 0.0457342864056912 4595 5290268
SGTC_842 0271-0008 11.1 µM -1.69481593850274 0.0412864288034736 no 3236 0.0450551714793984 4596 1221709
SGTC_130 0136-0219 337.655 µM -1.70248162958838 0.0406057729340274 no 3237 0.0443325596524598 4507 234244
SGTC_1418 3966-3099 2.4 µM -1.70505495002862 0.0403793338363456 no 3238 0.0440920882573536 4610 740335
SGTC_288 1315-0019 35.1 µM -1.71101664723487 0.0398586732192838 no 3239 0.0435390198770492 4629 6811474
SGTC_2532 xanthone 78.9 µM -1.71469618977449 0.0395400554981613 no 3240 0.0432004712569235 4602 7020 An insecticide.
SGTC_3013 9080133 71.4286 µM -1.71548012917016 0.0394724412835003 no 3241 0.0431286177417541 4630 17050193
SGTC_1380 2291-0730 164 µM -1.72752130015198 0.0384456665406955 no 3242 0.0420370415856782 4604 2999191
SGTC_1435 4092-0789 56.7 µM -1.7298008112275 0.0382537604910263 no 3243 0.0418329347353312 4618 2248285
SGTC_2096 5468907 200 µM -1.73403412031951 0.0378994418330892 no 3244 0.0414560146600009 4609 759785
SGTC_1754 st042065 16.137 µM -1.73478609961976 0.0378367837892864 no 3245 0.041389349592065 4353 1126236 YIL048W NEO1
SGTC_537 1334-0398 209 µM -1.73774689603182 0.0375908991345229 no 3246 0.0411277107477024 4619 5846986
SGTC_658 3253-0951 102 µM -1.73782134588329 0.03758473316822 no 3247 0.0411211491087907 4613 1184878
SGTC_2983 9022671 12.99 µM -1.74398083193717 0.0370774553770174 no 3248 0.0405812161418646 4593 6405161
SGTC_2436 5633522 8.09 µM -1.74446007058182 0.0370382224053399 no 3249 0.0405394490947254 4586 5724242
SGTC_415 dibenzyl ketone 100 µM -1.75177643588002 0.0364434688638972 no 3250 0.0399061288067789 4586 7593
SGTC_1053 3366-3204 134 µM -1.75472687890223 0.0362058467264002 no 3251 0.0396530180549947 4602 3632071 YPR165W RHO1
SGTC_2003 4023581 200 µM -1.75523447678868 0.03616509409168 no 3252 0.0396096044673553 4610 16641307
SGTC_585 0kpi-0023 191 µM -1.7587736100416 0.0358819965597193 no 3253 0.0393079844259913 4559 64601
SGTC_1641 st009299 47.1 µM -1.76931234202918 0.0350497327101659 no 3254 0.0384208824534245 4554 4046054
SGTC_1717 st033143 58.0435 µM -1.77152837115526 0.0348767599827447 no 3255 0.0382364395451536 4609 674616
SGTC_362 0310-0100 9.03 µM -1.77341977684042 0.0347296806915976 no 3256 0.0380795871515623 4631 790235
SGTC_2172 5754775 163.918 µM -1.7846434745911 0.0338673495847885 no 3257 0.0371595824687571 4603 2263357
SGTC_837 0091-0265 12.5 µM -1.78566426317335 0.0337898026272351 no 3258 0.0370768174807855 4633 759367
SGTC_486 niguldipine 82 µM -1.78710717634893 0.0336804370854694 no 3259 0.0369600839205935 4689 1236 A calcium channel blocker.
SGTC_287 k060-0039 29.6 µM -1.79247478575468 0.0332761538062513 no 3260 0.0365284723047539 4658 5861974
SGTC_111 0083-0039 52.457 µM -1.79864148017744 0.0328166265563128 no 3261 0.0360377056795506 4608 759313
SGTC_1386 3228-0095 33.8 µM -1.79895491326427 0.0327934106791277 no 3262 0.036012906516669 4627 870181
SGTC_2002 4023503 131 µM -1.81933229959014 0.0313128695887478 no 3263 0.0344303742409836 4609 4736863 YCR052W RSC6
SGTC_2060 5238662 140 µM -1.82700465085215 0.0307699458475919 no 3264 0.0338495350593942 4608 790130
SGTC_1966 st070145 16.1 µM -1.82826130099995 0.0306817678329579 no 3265 0.0337551724110875 4614 3748532
SGTC_2158 5657123 3.6195 µM -1.83105711389413 0.0304863386205365 no 3266 0.0335460093789999 4642 2858827
SGTC_640 3381-0960 37.1 µM -1.83265621135975 0.0303750249549632 no 3267 0.0334268565475899 4688 1745025
SGTC_3175 9106517 49.47 µM -1.83396647357869 0.0302840684095492 no 3268 0.033329485495523 4650 41468073
SGTC_2462 5162487 171.77 µM -1.83768042174508 0.0300274773718789 no 3269 0.0330547552340088 4620 2259986
SGTC_895 0964-0006 13.7 µM -1.84430078849201 0.0295745577238752 no 3270 0.032569658329915 4644 6738897
SGTC_916 4466-0038 42 nM -1.84472874997149 0.0295454757380729 no 3271 0.0325385032500807 4673 5722064 YGL116W CDC20
SGTC_1730 st033808 45.1 µM -1.85022989326025 0.0291737564250969 no 3272 0.0321402110893917 4574 1045166
SGTC_805 3852-0218 479 µM -1.852784593978 0.0290024576426262 no 3273 0.031956619631702 4635 6615355
SGTC_2336 9001819 198.65 µM -1.85828228799429 0.0286366579005273 no 3274 0.031564468862311 4622 2989602
SGTC_1759 st043059 70 µM -1.8842922079974 0.0269576737775639 no 3275 0.0297627304142373 4668 669426
SGTC_357 1325-0123 420 µM -1.8860870716576 0.0268449080903471 no 3276 0.0296416110957073 4636 1098503
SGTC_1000 4048-0884 8.67 µM -1.89032147262977 0.0265804337226095 no 3277 0.0293574893447711 4652 13040088
SGTC_1776 st049249 45.9 µM -1.90417350571739 0.0257304189331375 no 3278 0.0284437955247337 4672 1822314
SGTC_1139 k015-0024 46.9 µM -1.91306170889155 0.0251970790355322 no 3279 0.0278700765008615 4675 2766652
SGTC_1907 st060210 83.7 µM -1.91375159557793 0.0251560724337226 no 3280 0.0278259515071545 4652 688793
SGTC_280 3448-3607 3.04 µM -1.92147801900535 0.0247006255228532 no 3281 0.0273357354637624 4638 626179
SGTC_1428 4049-0204 61.7 µM -1.92576900014213 0.0244506880647503 no 3282 0.0270666119255212 4696 X1428
SGTC_2250 alverine citrate 130 µM -1.94841351577067 0.0231666120514353 no 3283 0.0256827519400823 4534 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_1618 st003135 44.5 µM -1.95279608197018 0.0229247681811417 no 3284 0.0254218814981804 4663 1270615
SGTC_432 NS 1619 61.3 µM -1.96016327296551 0.0225230165102471 no 3285 0.0249883548485754 4627 4552 A K+/calcium channel activator.
SGTC_1685 st024049 53.0905 µM -1.96133248363559 0.0224598055492904 no 3286 0.0249201251681623 4700 1941139
SGTC_1831 st055328 12 µM -1.96184579238564 0.0224321018655609 no 3287 0.0248902202473963 4659 1103068
SGTC_2398 5228213 48.84 µM -1.96230503760829 0.0224073404653561 no 3288 0.024863490532974 4631 80771 YMR134W ERG29
SGTC_943 3253-1379 105 µM -1.96466920118751 0.022280234950084 no 3289 0.0247262684207922 4637 668464
SGTC_2873 9040596 71.43 µM -1.97346543237871 0.0218126487490138 no 3290 0.0242212795814962 4651 6463863
SGTC_1560 lithocholic acid 53.1 µM -1.98087270890513 0.0214253500813428 no 3291 0.023802775157426 4638 9903 A bile acid which acts as a detergent.
SGTC_1373 2887-0003 58.5 µM -1.98166592486155 0.0213842225377544 no 3292 0.0237583216883468 4652 776948
SGTC_495 decylubiquinone 155 µM -2.02088482734701 0.0194323783375747 no 3293 0.0216458444492936 4695 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_3295 9122362 53.5725 µM -2.03244548141275 0.0188867468344919 no 3294 0.0210542888551971 4682 4730473
SGTC_1790 st045711 43.5 µM -2.03284297372623 0.0188682204175214 no 3295 0.0210341949648464 4685 585119
SGTC_2464 5717415 7.67 µM -2.03475628421991 0.0187792605538388 no 3296 0.0209377008767462 4656 5285744
SGTC_1818 st052136 56.3 µM -2.03713935996153 0.0186689581677956 no 3297 0.0208180392832658 4397 674169
SGTC_756 0508-1999 28.3 µM -2.03919725274079 0.018574151293517 no 3298 0.0207151724967452 4699 6753853
SGTC_1207 2099-0101 141 µM -2.04498572145676 0.0183096725268386 no 3299 0.0204281329106525 4701 5837381
SGTC_3346 9158254 43.5805 µM -2.05049222601901 0.0180610614304753 no 3300 0.0201582108187206 4683 17639500
SGTC_2572 astragaloside iv 100 µM -2.06369942399318 0.0174764775598085 no 3301 0.0195231120054921 4650 45006101 An anti-inflammatory agent.
SGTC_265 mycophenolic acid 32.932 µM -2.07206715764061 0.0171145229298179 no 3302 0.0191295893154061 4726 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_2916 7875993 68.79 µM -2.08588426536865 0.016530873658077 no 3303 0.0184945539554995 4620 1299250
SGTC_326 k292-0812 17.5 µM -2.08781741078689 0.0164505898994338 no 3304 0.0184071542000424 4704 3579357
SGTC_2373 9071805 200 µM -2.11035767461325 0.015538861121039 no 3305 0.017413779627181 4703 10149009
SGTC_1797 st048695 56.8 µM -2.11907725644695 0.0151979817566616 no 3306 0.0170419692270122 4692 592262 YIL048W NEO1
SGTC_1133 3473-0247 50 µM -2.12617385017293 0.0149253116819763 no 3307 0.0167443933045393 4679 711311
SGTC_2719 novobiocin 32.65 µM -2.13997395090172 0.014407100342052 no 3308 0.016178435981848 4722 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_54 0159-0055 9 µM -2.1489569205521 0.0140781661996211 no 3309 0.0158189075120972 4692 3319099
SGTC_1920 st075728 45.7 µM -2.16012874491838 0.0136781285402949 no 3310 0.0153813521657417 4695 3400306
SGTC_3003 9075612 71.4286 µM -2.17325800285487 0.0132205702440766 no 3311 0.0148804522245236 4725 6501993
SGTC_2760 etidronate 98.04 µM -2.17886887506201 0.0130290996926396 no 3312 0.0146707052792954 4679 3305 A chelator and antioxidant.
SGTC_397 arbidol 50 µM -2.18132716062406 0.0129459690308734 no 3313 0.01457961344297 4724 131410 A RNA synthesis inhibitor.
SGTC_14 0354-0009 295 µM -2.18415806516132 0.012850806233814 no 3314 0.0144753175868572 4772 1713507
SGTC_1607 st000305 50.6 µM -2.23987955293543 0.0110971166819259 no 3315 0.0125493717071237 4736 5457690
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -2.24244169814189 0.0110217453243143 no 3316 0.0124664196969218 4714 1241132 A phosphatase inhibitor.
SGTC_2850 9015429 58.44 µM -2.244759185734 0.010953955088775 no 3317 0.0123917981094708 4702 6457570
SGTC_2221 6807166 181.081 µM -2.25151166936701 0.0107584984890528 no 3318 0.0121765743173353 4744 674925
SGTC_366 0181-0206 4.31 µM -2.26070369082795 0.0104973113022471 no 3319 0.0118888058891232 4695 274874
SGTC_1390 3413-2614 145 µM -2.27148963980998 0.0101978940972901 no 3320 0.0115586767168666 4735 3421432
SGTC_1716 st033144 30.6155 µM -2.2952791501006 0.00956371343644327 no 3321 0.0108585658535813 4702 674617
SGTC_169 k015-0017 16.025 µM -2.33013933640619 0.00869673517141874 no 3322 0.00989939398530953 4695 1840002
SGTC_2164 5685496 200 µM -2.33523344267649 0.00857599539189759 no 3323 0.00976561448958262 4732 759046
SGTC_2273 7815444 169.05 µM -2.37209637239253 0.00774526296841242 no 3324 0.00884373829513283 4701 2824616
SGTC_237 nikkomycin 200 µM -2.37618681942688 0.00765759649311482 no 3325 0.00874630187316805 4757 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_2108 5365811 200 µM -2.401038404288 0.00714351620678744 no 3326 0.00817431030560652 4753 780283
SGTC_2625 euphol 100 µM -2.42139072915904 0.00674543611717184 no 3327 0.00773062429318363 4727 6708538 A triterpene alcohol.
SGTC_611 3453-1652 23.7 µM -2.43966809304481 0.00640478082276516 no 3328 0.0073503808107079 4746 1560575
SGTC_1728 st035614 33.7865 µM -2.45468926461448 0.00613630479605238 no 3329 0.00705032078310255 4723 15945546
SGTC_1233 0325-0408 14.2 µM -2.46585996521111 0.00594316210454035 no 3330 0.00683423796322635 4773 12874
SGTC_2130 NSC 7 2.4545 µM -2.47343295547928 0.00581530907435298 no 3331 0.00669109553786964 4753 21448
SGTC_278 4092-0821 23.9 µM -2.49908440481666 0.0054001847277351 no 3332 0.00622573253284305 4738 877900
SGTC_2257 7960413 200 µM -2.51062022993669 0.00522224200407064 no 3333 0.00602596370339828 4776 2974689 YIL048W NEO1
SGTC_41 0478-0632 82.643 µM -2.52326539173192 0.00503319799367862 no 3334 0.00581353075355728 4735 3750424
SGTC_2260 7964312 200 µM -2.53485902636928 0.00486525493245287 no 3335 0.00562462932304334 4774 231951
SGTC_1619 st003326 88.7 µM -2.54756851503039 0.00468690286181511 no 3336 0.00542382746972434 4739 2849032
SGTC_1427 4048-4900 550 nM -2.58977873623069 0.00413567932781717 no 3337 0.00480188191140387 4772 24132586
SGTC_2976 9009005 19.48 µM -2.60313098005796 0.00397380919557807 no 3338 0.00461883271886368 4750 2993148
SGTC_270 tamoxifen 5.46 µM -2.71887719365259 0.00279155791753122 no 3339 0.00327519614946389 4767 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_22 0964-0034 14.468 µM -2.72501019605219 0.00273884774551476 no 3340 0.00321497506874558 4778 138402
SGTC_418 lividomycin a 100 µM -2.75985093651774 0.00245609518540826 no 3341 0.00289138703081992 4783 72394 An antibiotic.
SGTC_1296 1068-0102 11.9 µM -2.78875027829146 0.00224189364461343 no 3342 0.002645592326541 4790 767053
SGTC_33 0986-0033 35.816 µM -2.8505776216807 0.00183941126321553 no 3343 0.00218199486192872 4780 2848082
SGTC_564 3555-0129 330 µM -2.92980477691463 0.00141990638695567 no 3344 0.00169587508915306 4795 563260
SGTC_129 0088-0017 176.636 µM -3.01176590117912 0.00107953588116882 no 3345 0.0012986640735719 4761 182446
SGTC_2695 st077686 51.995 µM -3.05567696969623 0.000929667789612746 yes 3346 0.00112276520665474 4773 2876092
SGTC_127 0180-0333 59.125 µM -3.06304221428822 0.000906488541524368 yes 3347 0.00109549574804332 4777 771601
SGTC_419 nsc-638432 893 µM -3.11559798205543 0.000755899609337649 yes 3348 0.000917861753601816 4798 368090
SGTC_2888 9058547 12.99 µM -3.13916434483432 0.000696167265978242 yes 3349 0.000847151977714185 4776 16476514
SGTC_3007 9078383 71.4286 µM -3.23527985753392 0.00049489738705729 yes 3350 0.000607617778055464 4801 6496995
SGTC_462 ag-879 158 µM -3.36147627943329 0.000311956061258461 yes 3351 0.000387635076476246 4796 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_295 k015-0027 31 µM -3.47046224432331 0.000206847920322621 yes 3352 0.000259781690538156 4809 3887424
SGTC_99 0109-0120 622.8 µM -3.59652403299747 0.000126777632397909 yes 3353 0.000161248900215055 4803 759414
SGTC_2897 9048598 12.99 µM -3.70678909390855 8.1583299104909e-05 yes 3354 0.000104951801618314 4802 6467404
SGTC_1430 4049-0248 69.1 µM -3.81216148713369 5.29503208863736e-05 yes 3355 6.88784113343318e-05 4808 22774488
SGTC_1727 st034309 9.9045 µM -8.26002771574504 2.79406066846417e-17 yes 3356 7.28193234969591e-17 4810 870305