SGTCid condition conc unit YCR050C|YCR050C.score YCR050C|YCR050C.strain.pval YCR050C|YCR050C.strain.significant YCR050C|YCR050C.strain.rank expt.zyg.pval expt.zyg.rank CID description SGTC_target_orf SGTC_target_gene
SGTC_2322 7413319 38.22 µM 8.92659225242874 2.58583862557738e-19 yes 1 2.19666577309087e-19 27 1840400
SGTC_3023 9089636 49.47 µM 7.78540109944213 3.47719990406663e-15 yes 2 3.47461933895495e-15 1 17249241
SGTC_103 0844-0104 51.839 µM 7.43810450626945 4.90331148149457e-14 yes 3 5.10701225627544e-14 54 5375804
SGTC_1247 0448-0043 5.84 µM 7.02289039523963 9.97685180778121e-13 yes 4 1.08662348358539e-12 6 3089013 YGL099W LSG1
SGTC_37 0566-0070 1.56 µM 5.89678984542192 1.54782596779302e-09 yes 5 1.85320710923376e-09 5 1626686
SGTC_1166 k206-0078 225 µM 5.61020137716444 8.28938508430912e-09 yes 6 1.01045656640587e-08 5 5404595
SGTC_568 1193-0097 7.48 µM 5.13265010626488 1.14358882187759e-07 yes 7 1.42845357993034e-07 82 3646150
SGTC_1248 0469-0687 58.6 µM 5.01251120597988 2.13965653536187e-07 yes 8 2.68621228228457e-07 10 4017482
SGTC_364 0083-0097 67.7 µM 4.88889752467803 4.01932006466385e-07 yes 9 5.07011303195482e-07 12 5207356
SGTC_88 0180-0332 8.668 µM 4.76258256448576 7.54267779368488e-07 yes 10 9.55654775580194e-07 9 3101745
SGTC_1352 1496-0991 99 µM 4.62407057678559 1.47859242837426e-06 yes 11 1.88140871001326e-06 17 3000039
SGTC_1175 0741-0056 27.6 µM 4.34864391881763 5.34601605385833e-06 yes 12 6.84909565609067e-06 9 765927
SGTC_717 1532-0246 73.2 µM 4.33574123778093 5.66796097869047e-06 yes 13 7.26348782785588e-06 24 9561992
SGTC_1879 gemcitabine 100 µM 4.32184739743347 6.03530477627469e-06 yes 14 7.73640968790838e-06 9 60750 A nucleoside analog which inhibits DNA replication.
SGTC_3268 9137683 49.47 µM 4.14531828496722 1.31956624082909e-05 yes 15 1.69671009603876e-05 8 1953228
SGTC_805 3852-0218 479 µM 4.07017378579837 1.82490041732087e-05 yes 16 2.34890402200091e-05 68 6615355
SGTC_419 nsc-638432 893 µM 4.06657911901732 1.8531818834617e-05 yes 17 2.38541464001795e-05 11 368090
SGTC_2286 7945697 125 µM 4.03905673454905 2.08392653610602e-05 yes 18 2.68332921850077e-05 53 1245733
SGTC_436 n,n-dimethylsphingosine 3.3 µM 4.00695774920147 2.38746480253732e-05 yes 19 3.07529301851201e-05 26 5282309
SGTC_1206 3978-0017 132 µM 3.96384560083673 2.86155543792024e-05 yes 20 3.68759815961474e-05 35 3873677
SGTC_723 4182-0001 115 µM 3.95853312705886 2.92579584415171e-05 yes 21 3.77057414366291e-05 27 744821 YLR208W SEC13
SGTC_3013 9080133 71.4286 µM 3.93818645604063 3.18469178995581e-05 yes 22 4.10498935408608e-05 19 17050193
SGTC_1073 triclabendazole 3.09 µM 3.92062057111633 3.42550479415462e-05 yes 23 4.4160616205554e-05 26 50248 An antihelmetic and likely tubulin inhibitor.
SGTC_2029 5175081 200 µM 3.88828985787536 3.91442069212258e-05 yes 24 5.04765109497853e-05 18 1380876
SGTC_2266 7929956 200 µM 3.87663473872792 4.10632208802801e-05 yes 25 5.29555850592792e-05 38 2967153
SGTC_963 1269-2853 151 µM 3.83811385046207 4.80577378370235e-05 yes 26 6.19914990391664e-05 28 3668223
SGTC_2277 7947813 106.88 µM 3.81668543737412 5.24210667469963e-05 yes 27 6.7628214901916e-05 28 1246798
SGTC_45 0kpi-0036 14.9 µM 3.78708853713725 5.906546984751e-05 yes 28 7.62113998256298e-05 31 2795021
SGTC_3037 9091026 49.47 µM 3.7291896406018 7.44233099675023e-05 yes 29 9.60482724848448e-05 133 25236398 YIL048W NEO1
SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 54.9 µM 3.7066361665508 8.13665508197132e-05 yes 30 0.000105015167179781 63 442882
SGTC_788 1182-0090 188 µM 3.58655868617276 0.000129798447709959 yes 31 0.000167535341080578 97 5715185
SGTC_1862 st057513 3.81 µM 3.47113773267065 0.000200823992249611 yes 32 0.000259129049946231 28 5393163
SGTC_2042 p-Dimethylaminoacetophenone 200 µM 3.46445230423216 0.000205888585459513 yes 33 0.000265656174037995 37 75037 A free radical scavenger.
SGTC_3199 9111318 49.47 µM 3.4506801339191 0.000216700037092776 yes 34 0.000279587934397068 37 8548020
SGTC_905 2-aminofluorene 215 µM 3.433020658904 0.000231339186825544 yes 35 0.000298448307674028 48 1539 An established DNA mutagen. YPR165W RHO1
SGTC_1497 4476-2978 41.3 µM 3.40941134444599 0.000252354691013985 yes 36 0.000325516171638793 26 1528379
SGTC_1349 flufenamic acid 69 µM 3.39560105571335 0.000265459289716474 yes 37 0.00034239044965328 30 3371 A non-steroidal anti-inflammatory.
SGTC_2867 9039098 71.43 µM 3.36677681676403 0.000294878935442123 yes 38 0.000380261054304589 58 6463460
SGTC_1080 nisoldipine 24.4 µM 3.36143740766392 0.000300651279651684 yes 39 0.000387689641274536 47 4499 Nisoldipine (INN) is an L-type calcium channel blocker of the dihydropyridine class.
SGTC_2154 5570129 200 µM 3.34355549726955 0.000320757966956611 yes 40 0.000413560741882689 41 673366
SGTC_2855 9016525 58.44 µM 3.34285959497874 0.00032156517409184 yes 41 0.00041459921615241 43 43811474
SGTC_275 trichlorophene 5.69 µM 3.31272482313245 0.000358387600083407 yes 42 0.000461959174237317 266 62616
SGTC_2957 9076800 11.52 µM 3.29128482268173 0.000386930626108423 yes 43 0.000498654406786195 42 16459615
SGTC_794 k038-0031 316 µM 3.28912228694377 0.000389923849921807 yes 44 0.000502501740744994 133 6624242
SGTC_1381 2324-0066 62.1 µM 3.2171576987805 0.00050268609419121 yes 45 0.000647337073954772 58 10885928
SGTC_145 3737-0113 38.366 µM 3.21497701551577 0.000506533065917087 yes 46 0.000652274836122349 117 6849351
SGTC_3051 9093778 49.47 µM 3.20163628577152 0.000530667115470697 yes 47 0.000683247085416382 11 17217378
SGTC_372 0155-0182 15.9 µM 3.19619270351276 0.00054081699594898 yes 48 0.000696270365365714 60 771486
SGTC_1361 1608-0041 5.61 µM 3.18327936913025 0.000565617102024294 yes 49 0.000728085208590022 43 X1361
SGTC_1131 3454-3128 32.3 µM 3.14004991187978 0.00065649383024174 yes 50 0.000844595262116404 87 710982
SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 100 µM 3.13944972717368 0.000657845421766246 yes 51 0.000846327275585099 65 5379071
SGTC_2475 5812728 15.03 µM 3.1302304747303 0.000678932074828504 yes 52 0.000873346016458858 50 776160 YPL266W | YMR113W | YBL105C | YBR192W DIM1 | FOL3 | PKC1 | RIM2
SGTC_698 k064-0052 127 µM 3.11964711673032 0.000703906555161634 yes 53 0.000905339082120298 15 5088751
SGTC_2618 avocadyne 43.43 µM 3.11650246120698 0.000711488898268612 yes 54 0.000915050764185844 59 3015189
SGTC_2319 6033012 152.6 µM 3.10433378326454 0.000741544740679336 yes 55 0.000953540249202282 64 847246
SGTC_2040 5100729 123 µM 3.09671626566199 0.000760950398410505 yes 56 0.000978385345464289 70 11840 YJR013W | YDR381W GPI14 | YRA1
SGTC_272 doxorubicin 8.13 µM 3.0916888061708 0.000774012961802828 yes 57 0.000995106855120318 73 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_1327 1436-0082 2.18 µM 3.07028057217091 0.000831981335521749 yes 58 0.00106928883030692 55 15992205
SGTC_1848 st056003 16.4 µM 3.03660316347859 0.000931301320196796 yes 59 0.00119630109604223 48 146492
SGTC_2321 7390090 138.78 µM 3.00423098698854 0.00103692917022789 no 60 0.00133126549561586 75 649046
SGTC_366 0181-0206 4.31 µM 2.95216612368168 0.0012300703328274 no 61 0.00157776557542674 91 274874
SGTC_3254 9136651 49.47 µM 2.94711841436077 0.00125044720479555 no 62 0.00160375175141228 65 16454030
SGTC_816 0325-0417 81.3 µM 2.94595588199033 0.00125518371827626 no 63 0.00160979159006951 52 68101
SGTC_344 k064-0035 6.43 µM 2.91595378293542 0.00138324389873275 no 64 0.00177301512350412 68 5088750
SGTC_1161 k007-0610 110 µM 2.91438241335357 0.00139026904771291 no 65 0.00178196520449241 191 5843850
SGTC_2070 5230947 200 µM 2.88287395457979 0.00153819187770637 no 66 0.00197032543918232 57 2835538
SGTC_2259 7964009 200 µM 2.85544738088089 0.00167848650931339 no 67 0.00214881217955395 93 313134
SGTC_139 0099-0334 718.624 µM 2.83525577235258 0.00178911352769497 no 68 0.0022894505132301 95 97690
SGTC_2566 crystal violet carbinol 226 nM 2.82521597653039 0.00184655335052331 no 69 0.00236243781026861 102 68050 Cationic dye that binds acidic phospholipids including cardiolipin.
SGTC_1196 1588-0294 184 µM 2.81246081810503 0.00192194496663061 no 70 0.00245820064347538 62 6144269
SGTC_834 0312-0008 75.7 µM 2.80881911841258 0.00194397728051571 no 71 0.00248617875753962 110 6385573 YIL048W NEO1
SGTC_1609 st001574 46.4 µM 2.79868446469599 0.00200650497089917 no 72 0.00256556258522997 71 3960012
SGTC_1838 st055369 84.5 µM 2.75240522886541 0.00231588172117107 no 73 0.00295796333298044 68 676036
SGTC_1174 0739-0097 51.1 µM 2.75089898414253 0.0023266404425611 no 74 0.00297159836444813 103 728447
SGTC_2797 7859098 81.82 µM 2.7426222234371 0.00238657089979629 no 75 0.00304753810907876 101 972681
SGTC_1703 st026983 48.3 µM 2.73276351085068 0.00245977701071568 no 76 0.00314027047159812 73 1104023
SGTC_1329 1447-1697 50.6 µM 2.70990596876326 0.00263737965284575 no 77 0.00336511427075363 74 2840515
SGTC_733 4069-0007 56.1 µM 2.69337505352664 0.00277295623949196 no 78 0.00353663257945655 188 5717425 YNL287W SEC21
SGTC_235 0330-0087 5 mM 2.67485138833068 0.00293232308617238 no 79 0.00373811913762309 101 46494818 YHR062C RPP1
SGTC_2699 st077704 54.6 µM 2.67461926956114 0.0029343714362085 no 80 0.00374070796783742 127 645852
SGTC_577 r071-0003 38.6 µM 2.67454355178532 0.00293503989250849 no 81 0.00374155279903255 158 4568517 YMR134W ERG29
SGTC_2007 4011539 71.82 µM 2.67426213527726 0.00293752551419952 no 82 0.00374469424128126 142 45595301
SGTC_2243 6634756 200 µM 2.66140479114288 0.00305313206437773 no 83 0.00389076722180386 81 885676
SGTC_979 1426-2828 121 µM 2.65901798917707 0.0030750384811507 no 84 0.00391843892230232 105 747872
SGTC_2323 6148992 148.28 µM 2.63651322670814 0.00328865491836374 no 85 0.00418814672883519 100 2888220 YOR207C | YHR062C | YKL042W RET1 | RPP1 | SPC42
SGTC_2481 5478948 45.16 µM 2.6220132786462 0.00343326581953661 no 86 0.00437060125794036 131 77792
SGTC_1724 st037281 8.293 µM 2.61386894288081 0.00351697337101266 no 87 0.00447616846474821 155 574124 YDL195W SEC31
SGTC_2271 7849410 118.62 µM 2.61226057935539 0.00353371923244711 no 88 0.00449728340522309 79 972430
SGTC_1994 st072947 40.9 µM 2.59007682291001 0.00377210649664238 no 89 0.00479772578764723 95 5286565 YDL195W SEC31
SGTC_524 r073-0010 27.8 µM 2.57787102897229 0.00390933119982075 no 90 0.00497055469184146 143 2772106
SGTC_2592 piperlongumine 83.33 µM 2.57664699702132 0.00392333627544919 no 91 0.00498818880679415 113 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_1531 st059297 52.4 µM 2.5506113935111 0.00423207081469316 no 92 0.0053767076833622 101 7566702
SGTC_1387 3342-1166 1.8 µM 2.54596153835486 0.00428944153404438 no 93 0.00544885974135968 72 3418228
SGTC_288 1315-0019 35.1 µM 2.54183635073118 0.00434091978603187 no 94 0.00551358951066083 115 6811474
SGTC_1659 st012954 42.1 µM 2.54124210282012 0.00434838073365737 no 95 0.00552297014434313 84 24207262
SGTC_2477 5967686 25.23 µM 2.53448840219914 0.00443398410848608 no 96 0.0056305827356923 111 776118
SGTC_2249 haloperidol 116.36 µM 2.52089273308065 0.00461088858310778 no 97 0.00585287649415252 264 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_2414 st077232 92.9 µM 2.51800029424832 0.00464932731859427 no 98 0.00590116112340991 114 729801
SGTC_3205 9113483 49.47 µM 2.51394026832208 0.00470376489964993 no 99 0.00596953265531908 139 17018033
SGTC_750 4073-0104 132 µM 2.50145354476599 0.00487476995433792 no 100 0.00618423340133697 78 22330957
SGTC_2415 st077333 57.7 µM 2.48596442828579 0.00509457848000889 no 101 0.00646004396634593 182 2766255
SGTC_1421 4029-0249 71.4 µM 2.46157881691193 0.00545854683253205 no 102 0.00691635005333708 111 2894095
SGTC_2666 tannic acid 100 µM 2.42744428160903 0.00600680081842795 no 103 0.00760281115300299 155 16134267 A thiamine antagonist.
SGTC_1258 0671-0043 57.1 µM 2.4239641830433 0.00606535036364318 no 104 0.00767605976624812 143 4298767
SGTC_595 3909-8003 73.7 µM 2.4205659550843 0.00612301000050909 no 105 0.00774818393232747 117 699517
SGTC_926 2268-1401 59.4 µM 2.40690921441915 0.00635965875295639 no 106 0.00804408433102696 131 2931578
SGTC_2099 5377090 177.372 µM 2.37347463446709 0.00697351098708702 no 107 0.00881080168105554 147 2243829
SGTC_2627 acetyl isogambogic acid 100 µM 2.35687495904002 0.00729727406080666 no 108 0.00921472567348516 175 6857789 A caspase activator and apoptosis inducer.
SGTC_708 3448-5400 146 µM 2.34682733680852 0.00749961985809966 no 109 0.00946701332416968 188 3462195
SGTC_221 trifluoperazine 10.304 µM 2.33380336391609 0.00776925143286549 no 110 0.00980301029551416 376 5566 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels. YIL048W NEO1
SGTC_1621 st003705 32.4 µM 2.3189362389943 0.00808743591427607 no 111 0.0101992469105422 165 24207032
SGTC_1579 chlormadinone acetate 49.4 µM 2.30261518094354 0.00844987263361357 no 112 0.0106502521239097 125 45114258 A steroidal progestin.
SGTC_2360 9040895 200 µM 2.29208338206026 0.00869124735068133 no 113 0.0109504160666089 135 4914414
SGTC_2668 2',4'-dihydroxychalcone 15.08 µM 2.28946079825562 0.00875228567351617 no 114 0.0110262965560568 91 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_1614 st002383 48.6 µM 2.2889091439536 0.0087651726761623 no 115 0.0110423159352713 138 1947235
SGTC_878 0828-0289 13.7 µM 2.28359844093067 0.00889008749231685 no 116 0.0111975707501216 206 745350 YLR208W SEC13
SGTC_3184 9108758 49.47 µM 2.27517770040888 0.00909135298079164 no 117 0.0114476360106139 93 902885
SGTC_2058 5236698 133 µM 2.26483677325949 0.00934396281720961 no 118 0.011761348947235 164 766665
SGTC_1764 st044502 93.5 µM 2.25293262607861 0.00964234352029502 no 119 0.0121316986744715 168 8407
SGTC_58 0957-0393 9 µM 2.23349025558436 0.0101475912086966 no 120 0.0127583161045324 625 6997992
SGTC_1776 st049249 45.9 µM 2.23143859420439 0.0102022315054123 no 121 0.0128260453880375 185 1822314
SGTC_1481 3346-2004 36 µM 2.22515824404374 0.0103710894009049 no 122 0.0130353084389141 137 2770522
SGTC_2150 5556613 200 µM 2.21848607504916 0.0105531461354522 no 123 0.0132608540008259 158 743190
SGTC_786 4544-0069 423 µM 2.20946850480982 0.0108036203765972 no 124 0.0135710353637806 190 748821 YLR208W SEC13
SGTC_2152 5568786 200 µM 2.20797710676827 0.0108455407298529 no 125 0.0136229345365848 149 5399883
SGTC_502 l-744,832 89.3 µM 2.19877268741962 0.0111074058046604 no 126 0.0139470447483362 177 6610354 L-744,832 is a Ras farnesyltransferase inhibitor that has been demonstrated to induce tumor regression.
SGTC_2924 9010168 62.78 µM 2.1805916929203 0.0116408484773518 no 127 0.0146068150531498 186 2993929
SGTC_3163 9099914 49.47 µM 2.17986376587346 0.0116626617097686 no 128 0.0146337807590393 75 16268368
SGTC_1156 4092-0367 4.88 µM 2.17288475359827 0.011873603678792 no 129 0.0148944961271622 191 1357585
SGTC_982 1491-0518 27.5 µM 2.16618419930415 0.012079235679191 no 130 0.015148557029559 152 3091256
SGTC_2162 5663267 200 µM 2.15811894637519 0.0123308373327792 no 131 0.0154592925290615 138 6456493
SGTC_2365 9042475 200 µM 2.15360587243415 0.0124735974397404 no 132 0.0156355466780972 200 6464479
SGTC_2006 4011487 200 µM 2.15230527065831 0.0125150035527743 no 133 0.0156866594915014 269 45595294
SGTC_2759 disulfiram 3.38 µM 2.15107395872512 0.0125543133554232 no 134 0.0157351812870326 194 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_713 1488-1073 324 µM 2.15036041833329 0.012577142114299 no 135 0.0157633583528266 129 3312542
SGTC_1019 4262-0212 3.4 µM 2.14991111738595 0.0125915353200366 no 136 0.0157811230380734 256 4677213
SGTC_2054 5233173 129 µM 2.14831637952022 0.0126427373886944 no 137 0.0158443152808387 257 6889
SGTC_1611 st001856 99.4 µM 2.14804087045554 0.0126516013578016 no 138 0.0158552544112475 177 647478
SGTC_3014 9081533 49.47 µM 2.13940526923272 0.0129321745539917 no 139 0.0162014302855913 147 21367265
SGTC_856 0433-0016 11.3 µM 2.1391744597346 0.0129397468658244 no 140 0.0162107709146353 178 3911780
SGTC_138 0850-0259 40.9225 µM 2.13899246817816 0.0129457202799253 no 141 0.0162181391830763 399 6813004
SGTC_2813 7971799 71.43 µM 2.13297150080297 0.0131446921999287 no 142 0.0164635320703721 175 2234054
SGTC_3267 9137951 49.47 µM 2.12969527357532 0.0132540662196074 no 143 0.0165983897303097 105 16643986
SGTC_199 4063-0024 41.6 µM 2.12273660320851 0.0134889864037406 no 144 0.0168879649698155 137 306215
SGTC_1134 3477-0009 42.5 µM 2.11369985440378 0.0137994196706928 no 145 0.0172704554795876 230 3973534
SGTC_86 0417-1630 471.922 µM 2.10598515623111 0.014069294050999 no 146 0.0176028208805773 369 3634867
SGTC_469 w7 172 µM 2.10140105832347 0.0142317990357613 no 147 0.0178028875659907 108 45115570 A P450 inhibitor.
SGTC_1829 berberine 14.4 µM 2.08724826346479 0.0147437528640228 no 148 0.0184328493987505 170 2353 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_831 k061-1017 217 µM 2.08527536214153 0.0148163624559926 no 149 0.0185221562606528 340 1240153
SGTC_495 decylubiquinone 155 µM 2.07351344147103 0.0152556543111917 no 150 0.0190622607489388 210 2971 A Co-enzyme Q analog. A free radical scavenger.
SGTC_2507 purpurin 79.67 µM 2.07327237608828 0.0152647735359181 no 151 0.0190734690042943 235 6683 Anthraquninome derivative; natural product; red/yellow dye. YBR257W | YHR062C POP4 | RPP1
SGTC_1827 berberine 7.24 µM 2.06923772016103 0.015418096261354 no 152 0.0192618923492615 188 629413 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_806 3966-4455 5.86 µM 2.06868144172547 0.0154393390077405 no 153 0.0192879949143199 176 714982
SGTC_1741 st038134 10.228 µM 2.06803767085177 0.0154639542104658 no 154 0.0193182404554503 251 1272587
SGTC_3198 9112019 49.47 µM 2.06747582014213 0.0154854646401283 no 155 0.0193446701640714 177 45595555
SGTC_1877 wortmannin 25 µM 2.05832918280389 0.0158392722458948 no 156 0.0197792723235179 313 312145 A covalent inhibitor of PI 3-kinase.
SGTC_1717 st033143 58.0435 µM 2.05286856548263 0.0160537855309048 no 157 0.0200426632216463 251 674616
SGTC_1534 6-azauridine 81.6 µM 2.04622911980196 0.0163179574278436 no 158 0.0203669168047499 237 233502 6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP; used in antiviral studies. YHR062C RPP1
SGTC_3328 9140624 29.0385 µM 2.04003311260992 0.0165678352686517 no 159 0.0206735139108851 204 4904392
SGTC_1581 himbacine 57.9 µM 2.02177589984634 0.0173232530104141 no 160 0.0215997543047824 253 5281825 An alkaloid muscarinic receptor antagonist.
SGTC_3140 9094243 49.47 µM 2.02038755159769 0.0173818827550179 no 161 0.0216716018217031 227 19291112
SGTC_937 3122-0005 46.7 µM 2.01868690526025 0.0174539316545323 no 162 0.0217598859360152 233 759535
SGTC_1306 1185-0270 9.02 µM 2.01450550734021 0.017632164122813 no 163 0.0219782436202234 229 1548076
SGTC_969 1313-0238 134 µM 2.0079317420302 0.0179155114423199 no 164 0.0223252727851951 265 5212874
SGTC_1136 pergolide 1.05886 µM 2.00360462111891 0.0181041340135536 no 165 0.0225562152269281 319 47811 A dopamine receptor agonist.
SGTC_2961 9083290 32.55 µM 2.00175140152489 0.0181854335649018 no 166 0.0226557375543982 194 17741490
SGTC_243 5hr heat shock (37°C) + splitomicin 1 µM 1.99626934202771 0.018427751797996 no 167 0.0229523066163329 317 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_3166 9102297 49.47 µM 1.97972429163131 0.0191758156162045 no 168 0.0238672587325435 252 25237072
SGTC_1462 k081-0014 26.5 µM 1.97764082976545 0.0192718220630945 no 169 0.0239846198674187 135 3270634
SGTC_1392 3455-1037 33.9 µM 1.97172830399475 0.0195465000837355 no 170 0.0243203153717929 214 981132
SGTC_269 exalamide 29 µM 1.96692654793124 0.0197720151131565 no 171 0.0245958397062866 184 3316 A derivative of salicylamide.
SGTC_1771 st048882 4.1505 µM 1.96215091988379 0.0199984897012558 no 172 0.0248724580506766 236 4580403
SGTC_3273 9137859 49.47 µM 1.95156853881034 0.0205081890099003 no 173 0.0254947257610293 162 2377234
SGTC_1884 5633444 25 µM 1.94453762464797 0.0208528834756313 no 174 0.0259153264210969 287 5724239
SGTC_144 4161-2749 112.381 µM 1.94258845189439 0.0209493066080874 no 175 0.0260329516562668 186 797501 YMR168C CEP3
SGTC_718 1130-0073 349 µM 1.94026946826934 0.0210645151086056 no 176 0.0261734749349706 241 6740020
SGTC_3030 9087619 49.47 µM 1.93670518944209 0.0212426356037926 no 177 0.0263906955257082 225 25236973
SGTC_1150 3909-7983 10.9 µM 1.93160790814455 0.0214995784063372 no 178 0.0267039595158925 278 23965914
SGTC_918 glabranin 770.725 nM 1.93024751726158 0.0215685951739494 no 179 0.0267880882447961 255 124049 Also referred to as licorice root.
SGTC_1228 0124-0032 52.5 µM 1.92982539655786 0.0215900486673274 no 180 0.026814237806393 248 X1228
SGTC_1244 0416-0015 52.5 µM 1.92887419472733 0.021638457824818 no 181 0.0268732410561063 260 96201
SGTC_1202 1988-0068 29.6 µM 1.92701223938757 0.0217334831245018 no 182 0.0269890523173344 260 2850480
SGTC_314 1671-0008 2.74 µM 1.92660188699896 0.0217544728895733 no 183 0.0270146316582805 306 3913060
SGTC_2683 piperine 63.03 µM 1.92645717497965 0.0217618790771825 no 184 0.0270236571153349 196 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_731 3966-0296 387 µM 1.92224855483011 0.0219782047463592 no 185 0.0272872449379019 236 660956
SGTC_966 1300-0360 30.2 µM 1.9143431793449 0.0223894553856791 no 186 0.0277881603137722 256 70588
SGTC_2892 9047358 58.44 µM 1.90255935899276 0.0230145052743083 no 187 0.0285490332262753 179 6466771
SGTC_1876 myriocin 605 nM 1.90037337592754 0.0231320578768406 no 188 0.0286920691389134 223 301119 Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.[2] Due to this property, it is used in biochemical research as a tool for depleting cells of sphingolipids. YMR296C LCB1
SGTC_292 k038-0015 474 µM 1.89520157470201 0.0234121889797077 no 189 0.0290328508135262 237 46368540
SGTC_1330 1469-0054 61.8 µM 1.88986286456636 0.0237043493999786 no 190 0.0293881516249151 230 7102664
SGTC_1126 isoteolin 1.0172 µM 1.88959884974065 0.0237188767864731 no 191 0.0294058155667562 268 133323
SGTC_1153 4055-0057 267 µM 1.87913046481726 0.0243009610419578 no 192 0.0301133406397284 278 882706
SGTC_224 benfluorex 43.875 µM 1.87207098818911 0.0247002308306468 no 193 0.0305983915467158 147 2318 Inhibits enzymes in fatty acid oxidation, ketogenisis and gluconeogenesis.
SGTC_1968 st069590 43.6 µM 1.86567590933374 0.0250666605986565 no 194 0.0310433610622525 234 6384066
SGTC_3285 9112818 20.8695 µM 1.85606295414478 0.0256260360407409 no 195 0.0317222926683666 285 17017947 YPR165W RHO1
SGTC_16 erodoxin 22.806 µM 1.84626756030204 0.0262067395273788 no 196 0.0324266827544374 362 3967339 Erodoxin inhibits Ero1. YML130C ERO1
SGTC_593 1203-0218 61.7 µM 1.84623924344027 0.0262084340627704 no 197 0.0324287375844067 266 3666956
SGTC_1474 0330-0125 5.35 µM 1.83337101509627 0.0269880307323496 no 198 0.0333737075058892 262 X1474
SGTC_2299 7976368 114.88 µM 1.82547053985943 0.0274761867169714 no 199 0.0339650264691569 262 2979718
SGTC_951 1171-0579 82.7 µM 1.82467433454363 0.0275257885977395 no 200 0.0340250942685924 382 1616050 YPR165W | YDR526C RHO1 | YDR526C
SGTC_2972 9093619 59.92 µM 1.82207853214796 0.0276880202103112 no 201 0.0342215352951149 280 25236256
SGTC_2132 5317594 122.667 µM 1.81702190099464 0.0280063362738096 no 202 0.0346068799702734 227 794577
SGTC_1503 4585-0012 61.3 µM 1.81469077979436 0.0281541039854587 no 203 0.0347857213909444 247 2922052
SGTC_2934 9036370 36.88 µM 1.80494260680952 0.0287790821083706 no 204 0.0355418317966391 319 6462800
SGTC_2706 st078239 82.5 µM 1.79705312242707 0.029293302292993 no 205 0.0361635933672638 268 15434492
SGTC_177 1327-0068 8.361 µM 1.79470552853118 0.0294477786029617 no 206 0.03635031462612 328 15389900 YOR207C | YLR033W RET1 | RSC58
SGTC_1461 k072-0203 53.8 µM 1.78207578137193 0.0302904903633682 no 207 0.0373684373116686 279 5418714
SGTC_3334 9142812 21.919 µM 1.76870741756875 0.0312041603213979 no 208 0.0384713568956329 291 45283678
SGTC_2804 7954240 19.48 µM 1.76256997788516 0.0316311996124099 no 209 0.038986522148869 330 828705
SGTC_3209 9113616 49.47 µM 1.74193192100603 0.0331027470991908 no 210 0.0407601787759614 336 16649353
SGTC_1374 2889-5571 141 µM 1.73921570695563 0.0333005547993961 no 211 0.0409984138247394 349 2853281
SGTC_624 k048-0052 28 µM 1.73854054147008 0.0333498743495415 no 212 0.0410578064915515 290 6835531
SGTC_1533 dihydroergotamine mesylate 29.4 µM 1.73819598024741 0.0333750670612911 no 213 0.0410881435847225 295 71171 A 9,10alpha-dihydro derivative of ergotamine. It is used as a vasoconstrictor, specifically for the therapy of migraine disorders. [PubChem] DrugBank Mode of Action: Two theories have been proposed to explain the efficacy of 5-HT1D receptor agonists in migraine: 1) activation of 5-HT1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, leads to vasoconstriction, which correlates with the relief of migraine headache and 2) activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
SGTC_36 0335-0881 14.2 µM 1.73631558980929 0.0335128287098885 no 214 0.0412540240842776 403 23828853
SGTC_3174 9107204 49.47 µM 1.73316532611927 0.0337446729639055 no 215 0.041533144003882 319 3938802
SGTC_3333 9141820 12.094 µM 1.73062539762847 0.0339325590253695 no 216 0.0417592994185385 264 1939433
SGTC_1872 amphotericin b 148 nM 1.72907474278545 0.0340476879866123 no 217 0.041897859444721 307 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. YNL221C POP1
SGTC_2784 7567673 72.73 µM 1.7240941663145 0.0344196472990931 no 218 0.0423454225278294 368 3471247
SGTC_2097 5376186 200 µM 1.71954909642902 0.0347619896856606 no 219 0.0427572179490367 331 742755
SGTC_2775 cyproheptadine 69.59 µM 1.70853583955088 0.0356031327814026 no 220 0.0437684810935495 296 2913 A selective serotonin reuptake inhibitor.
SGTC_1900 st060200 72.8 µM 1.7073885371981 0.0356917101156934 no 221 0.0438749297573605 315 688945
SGTC_1786 berberine 21.6 µM 1.70515530645066 0.0358646443523636 no 222 0.0440827315094116 359 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_591 4299-0174 154 µM 1.70441563763306 0.035922073051672 no 223 0.0441517322542735 289 5509088
SGTC_1947 st076332 61.6 µM 1.70201729625851 0.0361088012421936 no 224 0.0443760629849654 260 24208416
SGTC_1231 0242-0792 125 µM 1.69871842582483 0.0363669399283783 no 225 0.0446861249885254 309 3707635
SGTC_1207 2099-0101 141 µM 1.67683895998565 0.0381174899980256 no 226 0.0467869884744726 368 5837381
SGTC_2171 5739187 198.077 µM 1.67606163480242 0.0381809255539771 no 227 0.0468630602634776 278 2262761
SGTC_2211 7117706 200 µM 1.67085023170388 0.0386084417802596 no 228 0.0473756319263182 295 822771
SGTC_1464 k208-0027 110 µM 1.66753569751164 0.0388823724587146 no 229 0.0477039661569796 345 X1464
SGTC_95 0471-0001 561.058 µM 1.66387205659427 0.0391869947015201 no 230 0.0480690001476305 356 4015405
SGTC_2936 9038235 15.59 µM 1.65884798997444 0.0396078882229584 no 231 0.0485732136140228 350 4749415
SGTC_1806 st050005 60.3 µM 1.65800332733342 0.039679009927068 no 232 0.0486583973899609 332 5194765
SGTC_2762 leflunomide 42.06 µM 1.65674587143461 0.0397850817035537 no 233 0.0487854323254694 379 3899 A prodrug with immunosuppresive properties, leflunomide is converted to an active metabolite that inhibits dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC). YBL105C PKC1
SGTC_1733 st037357 54.9 µM 1.65542760886331 0.0398965301780166 no 234 0.0489188947350809 379 1272339 YGL099W LSG1
SGTC_2835 9006588 71.43 µM 1.64479088663031 0.0408050918733695 no 235 0.0500064710970944 375 2345538
SGTC_1026 k007-1105 30.6 µM 1.64430089984817 0.0408473464813302 no 236 0.05005703178229 442 7066794
SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 19.1 µM 1.6330435036722 0.0418279568829142 no 237 0.0512299236998399 343 6312947
SGTC_2485 5633444 17.78 µM 1.63294931182029 0.0418362414715852 no 238 0.051239828866577 378 5724239
SGTC_2688 kanamycin b 96.69 µM 1.63169058509397 0.041947079606867 no 239 0.0513723422071534 906 636396 Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. Kanamycin interacts with the 30S subunit of prokaryotic ribosomes resulting in mistranslation and indirect inhibition of translocation during protein synthesis.
SGTC_339 3091-4833 71.4 µM 1.63012285066534 0.042085459956433 no 240 0.0515377675665792 317 3240077
SGTC_1142 3253-1408 9.78 µM 1.62925449045831 0.0421622669984387 no 241 0.0516295779638248 340 256655
SGTC_707 0865-0008 204 µM 1.62802749438253 0.0422709889664524 no 242 0.0517595280047269 340 723043
SGTC_1013 4112-3890 241 µM 1.62698188357624 0.0423638176143699 no 243 0.0518704727495356 374 705171
SGTC_3113 9123498 49.47 µM 1.62403951318184 0.0426259245456042 no 244 0.052183687899984 330 8897275
SGTC_2284 7945075 39.21 µM 1.62115208565857 0.0428844102876049 no 245 0.0524925128847869 402 1245402
SGTC_2907 7721985 69.9 µM 1.60986878824933 0.0439066741674446 no 246 0.0537132520489217 376 3267881
SGTC_600 1495-0418 41.6 µM 1.60212032078602 0.0446199994271179 no 247 0.0545645026119903 342 5377768
SGTC_2830 7992007 71.43 µM 1.60155368479994 0.044672528197724 no 248 0.0546271697812164 341 1952075
SGTC_1661 st013063 9.66 µM 1.60051847695573 0.0447686235186471 no 249 0.0547418056528915 404 721395
SGTC_2333 9017922 200 µM 1.59989180709646 0.0448268762859535 no 250 0.0548112935854867 367 3163164
SGTC_1545 lovastatin 49.4 µM 1.59875303336044 0.0449328884210391 no 251 0.0549377443148798 416 12923612 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR107C CDC12
SGTC_1521 st012942 49.4 µM 1.59745517913018 0.0450539558541486 no 252 0.0550821404984111 411 24207259
SGTC_797 k781-0471 270 µM 1.593091677013 0.04546292164254 no 253 0.0555698131032946 374 23738129
SGTC_582 0987-0078 156 µM 1.5896611026619 0.0457865412780681 no 254 0.0559556079668555 525 1625765
SGTC_265 mycophenolic acid 32.932 µM 1.58916824116258 0.0458331865800888 no 255 0.0560112072430306 399 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation. YHR062C RPP1
SGTC_1299 1079-1439 3.74 µM 1.5864380611725 0.0460922678479618 no 256 0.0563199860953032 347 323161
SGTC_840 0245-0196 390 µM 1.58470144373796 0.0462576758969965 no 257 0.056517091854646 414 3827528
SGTC_827 3253-0474 693 µM 1.58412424888808 0.0463127575430855 no 258 0.0565827235905668 392 5402065
SGTC_1436 4092-1007 8.32 µM 1.58286740207776 0.0464328804926038 no 259 0.0567258450137651 349 2881121
SGTC_3122 9126309 49.47 µM 1.57523351786145 0.0471678701675801 no 260 0.0576012765786663 336 17591206
SGTC_126 0417-1624 672.48 µM 1.57468961717598 0.0472205907864316 no 261 0.0576640527887993 477 41912 YDL195W SEC31
SGTC_187 1488-2104 32.728 µM 1.57000958354699 0.0476761833846161 no 262 0.0582064408645275 394 2852859
SGTC_149 3970-0822 46.1 µM 1.56405195133665 0.0482612333345411 no 263 0.0589026842614096 548 3114250 YBL034C STU1
SGTC_712 r015-0009 80.6 µM 1.56012229140248 0.0486502665275166 no 264 0.0593654923517259 351 6813872 YLR060W FRS1
SGTC_2112 5488546 200 µM 1.55892132837594 0.048769659786427 no 265 0.0595075007858592 401 600757
SGTC_43 0570-0105 72.5 µM 1.55499376439765 0.0491617529458835 no 266 0.0599737772091681 524 1114046 YDL195W SEC31
SGTC_2824 7998404 51.95 µM 1.5448863197826 0.050182372663274 no 267 0.0611868815096793 373 837851
SGTC_1267 0828-0272 9.49 µM 1.54235699023842 0.0504404012576713 no 268 0.0614934335324783 440 745334
SGTC_128 0906-2981 13.371 µM 1.54092156435361 0.0505873052147019 no 269 0.0616679383977273 348 6740226
SGTC_1926 methyl fluorone black 53.6 µM 1.5404588193011 0.0506347359162953 no 270 0.0617242766987018 377 72721 Reacts with homocysteine.
SGTC_953 1188-0045 9.7 µM 1.53487835876773 0.0512095185854947 no 271 0.0624068551566822 430 6144426
SGTC_1085 doxorubicin 7.67 µM 1.53004967051357 0.0517110480526437 no 272 0.063002217336246 449 443939 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_863 0466-0191 129 µM 1.52623044111981 0.0521104895212603 no 273 0.0634762424083682 468 765160 YPR165W RHO1
SGTC_2178 5812956 200 µM 1.52128268343073 0.0526316001159615 no 274 0.0640944569459269 382 5403383
SGTC_2068 5226020 147 µM 1.51656318387063 0.0531325154747082 no 275 0.0646885032612629 462 1810509
SGTC_2257 7960413 200 µM 1.51536885816233 0.0532598755243596 no 276 0.0648395096431062 470 2974689 YIL048W NEO1
SGTC_1486 3970-0793 4.53 µM 1.51515232488622 0.0532829920101874 no 277 0.0648669166409104 392 2844330
SGTC_1165 k072-0275 30.3 µM 1.51385889897702 0.0534212402128688 no 278 0.0650308151932879 388 6153523 YGL055W OLE1
SGTC_2816 7982706 58.44 µM 1.51382084947112 0.0534253114451992 no 279 0.0650356415601548 429 2981853
SGTC_1109 tnp00067 928.257 nM 1.51314205763673 0.0534979823409401 no 280 0.0651217892321789 393 676295
SGTC_1037 k284-1091 78.7 µM 1.50876209926921 0.0539687819949527 no 281 0.0656797947767409 353 3334711
SGTC_2838 9002687 71.43 µM 1.5068845029402 0.0541716056912116 no 282 0.0659201321815861 385 6457060
SGTC_1553 gossypol 38.6 µM 1.50285982933969 0.054608395344401 no 283 0.0664375968740201 274 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_868 0527-0199 213 µM 1.49026862724143 0.0559928966561736 no 284 0.0680768090322514 443 2849450
SGTC_2037 5169046 200 µM 1.48915290535211 0.056116902498037 no 285 0.0682235544678812 396 5718022
SGTC_335 4077-0256 27.6 µM 1.48797200079753 0.0562483888179718 no 286 0.0683791388826475 490 3121989
SGTC_3035 9091303 49.47 µM 1.48775232165583 0.0562728754868339 no 287 0.0684081118315682 378 25237002
SGTC_946 3434-1334 87.4 µM 1.48567069803817 0.0565053222349351 no 288 0.0686831224150104 432 4047976
SGTC_910 3454-3003 490 µM 1.48500570749997 0.0565797383778456 no 289 0.0687711560989253 458 820824
SGTC_2654 protoveratrine a 100 µM 1.48427153960524 0.0566619855163913 no 290 0.06886844873605 410 5702278 A heart drug and vasodilator.
SGTC_1465 k213-0056 144 µM 1.47925084109079 0.0572269699359398 no 291 0.0695366430091567 416 24048857 YMR208W ERG12
SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 70 µM 1.47718416922148 0.0574608188927292 no 292 0.0698131380765072 556 6708739 YPR165W RHO1
SGTC_1544 7-methoxy-4-methylcoumarin 105 µM 1.47539817873465 0.0576635130157827 no 293 0.0700527623676732 440 390807
SGTC_2208 7283366 200 µM 1.47532567813303 0.0576717530534007 no 294 0.0700625030378031 436 898663
SGTC_2244 6635614 200 µM 1.46974951935843 0.0583082889172066 no 295 0.0708148028397498 294 836499
SGTC_351 caspofungin 25 nM 1.45938319608256 0.0595062893430955 no 296 0.0722298341959201 591 9963413 Caspofungin is an echinocandin antifungal that acts by inhibiting 1,3-beta-D-glucan synthase required for cell wall biosynthesis. YER133W | YER165W GLC7 | PAB1
SGTC_3331 9141060 1.957 µM 1.45896012926742 0.0595555884415416 no 297 0.0722880409051306 428 4906567 YPR165W RHO1
SGTC_691 1548-0686 185 µM 1.45799215699533 0.0596685046437043 no 298 0.0724213524222021 473 46495133
SGTC_1663 st014140 55.4 µM 1.4551341018008 0.0600028824273949 no 299 0.0728160699715441 503 4207120
SGTC_2881 9058953 51.95 µM 1.45426131493289 0.0601052859601872 no 300 0.0729369356917891 463 17122249
SGTC_1640 st009078 66.4 µM 1.45278794633999 0.0602784657796265 no 301 0.0731413198311962 381 690618
SGTC_3001 9076041 71.4286 µM 1.45170477301053 0.0604060309508707 no 302 0.0732918558007932 442 16004211
SGTC_1348 1493-0373 93.8 µM 1.45095428945588 0.0604945391168661 no 303 0.0733962945248702 432 3010129
SGTC_1318 1280-3875 124 µM 1.44784723172175 0.0608620495455317 no 304 0.0738298900450324 479 373245
SGTC_2036 5160441 105 µM 1.43955311389749 0.0618516500438974 no 305 0.0749969363695183 536 134534 YIL048W NEO1
SGTC_1935 st074532 41.6 µM 1.43933562618083 0.0618777672566451 no 306 0.0750277267954568 543 2829742
SGTC_1613 st002381 52.1 µM 1.43860112082414 0.0619660346338369 no 307 0.0751317843119469 450 551167
SGTC_579 4491-1009 110 µM 1.43497969067595 0.0624026683802035 no 308 0.0756464425210811 583 1271041
SGTC_373 0844-0104 25.9 µM 1.43253413062449 0.0626988826728609 no 309 0.0759955087689022 481 5375804
SGTC_2117 5521686 200 µM 1.43240252922379 0.0627148536864685 no 310 0.0760143275689335 439 803312
SGTC_1542 7-hydroxy-3'-methoxyflavone 49.7 µM 1.43231113035545 0.0627259476266963 no 311 0.0760273995556287 473 5393153
SGTC_3295 9122362 53.5725 µM 1.43004718572096 0.0630012322855713 no 312 0.0763517383995094 429 4730473
SGTC_28 pentachloropyridine N-oxide 1.606 µM 1.42947161110836 0.0630713691814105 no 313 0.0764343643978252 449 140250 A respiratory chain inhibitor.
SGTC_1651 st011928 86.1 µM 1.42875764483721 0.0631584543393051 no 314 0.0765369515703635 459 720198
SGTC_2883 9059145 45.46 µM 1.42528016929174 0.0635839544909082 no 315 0.0770381150727912 415 16476510
SGTC_1224 0823-0416 294 µM 1.42422099909783 0.063713995612216 no 316 0.0771912539870733 461 3598164
SGTC_886 0866-0150 153 µM 1.42139622453034 0.0640618230945522 no 317 0.0776008017262661 487 271463
SGTC_2656 pseudo-anisatin 100 µM 1.41953274097001 0.0642920894003137 no 318 0.0778718792478893 411 6708809 A neurotoxin.
SGTC_1931 st074438 57.1 µM 1.41871394738899 0.064393468995027 no 319 0.0779912146431586 436 2787313
SGTC_124 0136-0217 7.121 µM 1.41350202609877 0.0650417016924075 no 320 0.0787540830330735 563 3976905
SGTC_2792 7535235 81.82 µM 1.41019892019725 0.0654551402399926 no 321 0.0792404772914214 443 1281891
SGTC_1107 amlodipine 47 µM 1.40653579148157 0.065916022024241 no 322 0.0797825421251728 485 2162 Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
SGTC_690 glyoxal 20.3 µM 1.40230885688437 0.0664509605742677 no 323 0.0804115183679726 515 7860 Glyoxal is a potent glycating agent that covalently cross-links proteins.
SGTC_146 3448-8650 53.125 µM 1.40073194411586 0.0666513849695314 no 324 0.0806471232376431 651 2891488 YIL048W NEO1
SGTC_523 1934-0222 13.7 µM 1.39848899924525 0.0669372671103925 no 325 0.0809831369223353 495 1361595
SGTC_1413 3910-0535 34.4 µM 1.39649455342917 0.0671922718534939 no 326 0.0812828098073848 479 2876951
SGTC_1950 st077106 7.18 µM 1.39414220165786 0.0674940022198096 no 327 0.0816373337412882 487 13831864
SGTC_1001 4048-4355 44.4 µM 1.39274786019447 0.0676733446004302 no 328 0.0818480251467379 464 21824233
SGTC_2951 9072950 58.06 µM 1.38745390493377 0.0683576152834907 no 329 0.0826516987780261 508 16488155
SGTC_1857 st056007 79.3 µM 1.38585643032392 0.068565142124382 no 330 0.0828953735855681 442 619834
SGTC_1378 2093-0007 380 nM 1.38399170025764 0.0688080022757004 no 331 0.083180498064048 494 3618014
SGTC_1472 k841-0093 193 µM 1.36942678937167 0.0707277980391199 no 332 0.0854329524955962 545 X1472
SGTC_3239 9133757 49.47 µM 1.36804367907715 0.0709122242181147 no 333 0.0856492021492891 463 17036923
SGTC_1535 tetrahydropapaveroline hydrobromide 54.3 µM 1.36725498156144 0.07101755569042 no 334 0.0857726985503637 491 2724278 An inhibitor of dopamine biosynthesis.
SGTC_1750 st081859 2.357 µM 1.36040549249004 0.0719373723244541 no 335 0.0868508206722231 713 5291695
SGTC_1428 4049-0204 61.7 µM 1.35604923358607 0.0725271087420699 no 336 0.0875417518828726 515 X1428
SGTC_1754 st042065 16.137 µM 1.35282070082069 0.0729665613145064 no 337 0.0880564589050651 660 1126236 YIL048W NEO1
SGTC_1702 st027038 51 µM 1.35031017627627 0.073309688352344 no 338 0.0884582547489954 541 5521182
SGTC_1822 st052468 42 µM 1.3470052612645 0.0737632692940053 no 339 0.0889892691042094 479 2873678
SGTC_1820 st053765 18.6 µM 1.34588225754147 0.0739178825276617 no 340 0.0891702458199881 492 3690829
SGTC_3241 9133421 49.47 µM 1.34571680939107 0.0739406820608596 no 341 0.0891969316077644 420 17018221
SGTC_765 1319-0117 244 µM 1.34439759831395 0.0741226678341757 no 342 0.0894099250233975 477 3487746 YGL099W LSG1
SGTC_2442 5158906 48.48 µM 1.3402327459511 0.0746994566041706 no 343 0.0900848443330764 527 1893835
SGTC_811 0416-0114 265 µM 1.33335945251233 0.0756588177801535 no 344 0.0912069359919629 504 6612453
SGTC_2348 9022543 33.42 µM 1.33056325615554 0.0760517807660344 no 345 0.0916663797439256 540 3162678 YDL140C RPO21
SGTC_405 ebelactone b 50 µM 1.32844009571028 0.0763511951483436 no 346 0.0920163804918623 531 5819825 Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
SGTC_2398 5228213 48.84 µM 1.32819277738067 0.0763861309580958 no 347 0.092057214917106 622 80771 YMR134W ERG29
SGTC_581 0958-0271 211 µM 1.32785404721305 0.0764339991996726 no 348 0.0921131640089676 632 4591145
SGTC_3261 9137475 49.47 µM 1.32484502541548 0.0768602266528744 no 349 0.0926112787866274 315 17027690
SGTC_2403 6032726 181.2 µM 1.32212524604536 0.0772470355340511 no 350 0.0930632241469472 525 2881040
SGTC_1642 st009582 77.7 µM 1.32193353167303 0.0772743569806418 no 351 0.0930951426934444 491 6739311
SGTC_2472 5377652 49.4 µM 1.31847065226665 0.0777691208309847 no 352 0.0936730715505596 585 1610903
SGTC_800 3448-7362 155 µM 1.31587965427635 0.0781408832321145 no 353 0.0941072192880293 811 15991913
SGTC_1201 1889-3372 45.9 µM 1.31404096381939 0.078405519469781 no 354 0.0944162096703899 510 5392199
SGTC_962 1254-0300 21.5 µM 1.31151381603938 0.078770351010322 no 355 0.0948421145387521 531 7340576
SGTC_1515 3460-0031 42.1 µM 1.30682440539613 0.0794507433706896 no 356 0.0956361772438784 460 2876596
SGTC_659 k018-0002 107 µM 1.30488604483941 0.0797332781699305 no 357 0.0959658269070045 553 6797879 YHR007C ERG11
SGTC_2291 7917025 104.35 µM 1.30093203677363 0.0803119685479379 no 358 0.0966408595033129 574 2964612
SGTC_2104 5389443 200 µM 1.29869154038494 0.0806412829925804 no 359 0.097024904218091 615 2244536
SGTC_1232 0279-0259 161 µM 1.29640515930609 0.0809783920408012 no 360 0.0974179677616425 554 1560000
SGTC_3249 9135183 49.47 µM 1.2962561399893 0.0810004006445369 no 361 0.0974436269269893 576 4902779
SGTC_549 1661-1316 519 µM 1.29590158669057 0.0810527826296189 no 362 0.0975046962672423 554 2857282
SGTC_2496 diffractaic acid 79.83 µM 1.29347067792124 0.0814126157695148 no 363 0.0979241595468118 569 94870 An apoptosis inducer which activates caspases.
SGTC_3082 9117008 49.47 µM 1.29042338786394 0.0818653884667645 no 364 0.0984518480358071 548 41448529
SGTC_3002 9075603 71.4286 µM 1.28690527489744 0.082390474238494 no 365 0.0990636532557576 575 20105405
SGTC_2989 9073649 71.4286 µM 1.27741987891746 0.0838188217426105 no 366 0.100727025134712 654 21367202
SGTC_1422 4031-0024 15.5 µM 1.27622438022833 0.0840001563224486 no 367 0.100938106319065 559 782427
SGTC_3144 9087057 49.47 µM 1.27567677621266 0.084083315810678 no 368 0.101034900701724 555 17249618
SGTC_460 trequinsin 123 µM 1.27374648737321 0.0843769436290023 no 369 0.101376637764865 595 5537 A vasodilator.
SGTC_2510 benzyl isothiocyanate 8.31 µM 1.27136363501677 0.0847404739214394 no 370 0.101799656699009 522 2346 DNA damaging agent; causes G2/M arrest.
SGTC_877 0771-0151 33.1 µM 1.27058641524949 0.0848593009948183 no 371 0.101937911155676 604 6166523
SGTC_2096 5468907 200 µM 1.26900282721433 0.0851017980847576 no 372 0.102220027851541 552 759785
SGTC_34 0469-0683 81.75 µM 1.26887587759157 0.0851212605230547 no 373 0.102242668530986 549 3690923
SGTC_1377 2944-0135 198 µM 1.26864858236211 0.0851561151136884 no 374 0.102283214339641 581 1894137
SGTC_2947 9072639 7.68 µM 1.26718537795897 0.0853807462786887 no 375 0.10254450642773 608 16488146
SGTC_1766 st045414 44.774 µM 1.2616120715915 0.0862404262698275 no 376 0.103544205127786 601 253960
SGTC_1767 st044992 70.3 µM 1.25902849812585 0.0866411305945214 no 377 0.10401001931002 580 9600693
SGTC_238 5hr heat shock (37°C) + nsc-638432 8.929 µM 1.25736519369961 0.0868998393404031 no 378 0.104310713390316 678 368090
SGTC_3161 9100388 49.47 µM 1.25733687765498 0.0869042485809787 no 379 0.104315837845662 570 25236368
SGTC_3134 9127454 49.47 µM 1.25549035501222 0.087192141312203 no 380 0.104650403607639 560 24262820
SGTC_258 haloperidol 50.781 µM 1.25540430769697 0.0872055743590692 no 381 0.104666013187015 560 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_1571 st070080 73.4 µM 1.25106505711677 0.0878849903788181 no 382 0.105455371429998 576 4315245
SGTC_3321 9137793 26.8275 µM 1.24921890540126 0.0881752448079579 no 383 0.105792509536454 614 4904192
SGTC_202 3594-0513 34.79 µM 1.24683354905615 0.0885513310519015 no 384 0.106229268149752 548 708429
SGTC_1039 k821-0043 94 µM 1.24384933594578 0.0890235167959457 no 385 0.106777509381198 596 15992768
SGTC_884 0851-0618 334 µM 1.24307817791432 0.0891458396790885 no 386 0.106919513170854 626 9642473
SGTC_1393 3470-5649 58.2 µM 1.24075734104444 0.0895147308578985 no 387 0.107347702239518 476 4108395
SGTC_2977 9011197 71.43 µM 1.23958448139977 0.089701585213578 no 388 0.107564561752788 509 2704722
SGTC_876 0720-0963 56.8 µM 1.23622571604363 0.0902382916564334 no 389 0.108187337147862 635 765861
SGTC_2015 5119600 184 µM 1.23223524394166 0.0908790361787693 no 390 0.108930610737096 613 2828786
SGTC_1308 1187-1617 41.4 µM 1.23162296151211 0.0909776474735748 no 391 0.109044979784771 641 2882570
SGTC_482 fipronil 114 µM 1.23073142037405 0.0911213767493284 no 392 0.109211666222174 522 3352 A inhibitor of GABA receptors and glutamate-gated chloride (GluCl) channels.
SGTC_2108 5365811 200 µM 1.23047317178163 0.0911630415808937 no 393 0.109259983688657 603 780283
SGTC_1141 3253-0389 52.6 µM 1.22942270741506 0.0913326650640812 no 394 0.109456680422909 575 5402031
SGTC_1684 st024538 14.6195 µM 1.22808093978573 0.0915496668304989 no 395 0.10970829265304 596 6732859
SGTC_3085 9117376 49.47 µM 1.22698098396868 0.0917278456032488 no 396 0.109914869121842 593 16480349
SGTC_223 busulfan 5 mM 1.22650858740586 0.0918044466149805 no 397 0.110003672873294 497 2478 A DNA alkylator.
SGTC_735 3076-0345 636 µM 1.22161600793716 0.0926005866257648 no 398 0.110926436077686 660 2888990
SGTC_510 ag-490 170 µM 1.21949365094595 0.0929475288601604 no 399 0.111328442092716 641 5328779
SGTC_2556 citropten 84.59 µM 1.21783891818371 0.0932186944248131 no 400 0.111642595858937 649 2775 A potential DNA crosslinker.
SGTC_1896 st058441 89 µM 1.21730894417359 0.0933056661823214 no 401 0.111743346272064 556 688759
SGTC_374 0880-0231 82.3 µM 1.21355129050267 0.093924038605291 no 402 0.112459558535566 619 6833587
SGTC_274 sirtinol 40.1 µM 1.21178354449986 0.094215988894302 no 403 0.112797624475371 610 6836442 NAD-dependent acetyltransferase inhibitor.
SGTC_752 1896-0090 130 µM 1.21134381651361 0.0942887155791105 no 404 0.112881831177623 616 772567
SGTC_186 3455-3465 67.277 µM 1.20885818799501 0.0947005927462272 no 405 0.113358666025488 510 755278
SGTC_2770 toltrazuril 17.5 µM 1.2013696041658 0.0959494902716359 no 406 0.114803930709559 668 68591 Kills coccidiodes.
SGTC_981 1488-1094 54.9 µM 1.19719127433123 0.0966515683122926 no 407 0.115616005046716 554 3449522
SGTC_684 1140-0066 328 µM 1.19700706389039 0.0966826075134462 no 408 0.11565190073057 676 6813534
SGTC_2081 5214970 32.255 µM 1.1970050836847 0.0966829412151005 no 409 0.115652286641157 607 2063512
SGTC_760 0568-0725 82.9 µM 1.19612143599644 0.0968319367884075 no 410 0.115824586806635 661 3916171
SGTC_2091 4-phenylthiadiazole 200 µM 1.19555690722251 0.0969272125947954 no 411 0.11593475818792 637 270010
SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 66.5 µM 1.19509571789255 0.0970050988160993 no 412 0.116024817423469 605 689007
SGTC_2170 morpholine 200 µM 1.19094679296247 0.097707840946438 no 413 0.116837236603984 639 121171 Reacts with secondary amines.
SGTC_3011 9081274 71.4286 µM 1.18782647631497 0.0982388120771874 no 414 0.11745089052146 674 6625322
SGTC_3337 9144342 33.5465 µM 1.18291141804483 0.0990794685692267 no 415 0.118422127983179 638 17682949
SGTC_1078 idebenone 36.1 µM 1.17942888955975 0.0996782862717644 no 416 0.119113718530226 685 3686 A short-chain Coenzyme Q analog that enhances superoxide formation, presumably by mediating electron transfer from N2 to oxygen.
SGTC_538 2922-0838 53.3 µM 1.17246085378901 0.100884364129343 no 417 0.12050603995494 718 777039
SGTC_1965 Pectolinarigenin 58.4 µM 1.17019385091537 0.101279038042525 no 418 0.120961483414809 647 5320438 An anti-inflammatory.
SGTC_3055 9094636 49.47 µM 1.16638166811174 0.101945254493266 no 419 0.121730083478995 608 25236176
SGTC_1844 rapamycin 4 nM 1.16482080912357 0.102218948228428 no 420 0.122045766926029 754 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR186C | YKL203C KOG1 | TOR2
SGTC_2734 clemastine 41.6 µM 1.16209299698614 0.102698547608882 no 421 0.122598845869258 501 26987 Clemastine is a selective histamine H1 antagonist.
SGTC_1940 st075990 51.1 µM 1.16153370923519 0.102797082356447 no 422 0.122712461425827 715 1084979
SGTC_1402 3909-7673 35.9 µM 1.16093098858774 0.102903345956646 no 423 0.12283498273976 641 5328014
SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 39.67 µM 1.15735708080431 0.103535089262808 no 424 0.12356325072817 585 279621
SGTC_2134 5324836 1.464 µM 1.15731911017306 0.103541816234647 no 425 0.12357100433965 581 699272
SGTC_2575 plumbagin 510 nM 1.15628856504891 0.103724511325848 no 426 0.123781572017278 635 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_1337 1486-1011 40.3 µM 1.15475269194028 0.103997224807772 no 427 0.124095857526255 645 X1337
SGTC_3040 9091894 49.47 µM 1.14751455672522 0.105289446280214 no 428 0.125584510210597 585 25236966
SGTC_3145 9085516 49.47 µM 1.1444477711433 0.105840447927751 no 429 0.126218993167325 629 25236195
SGTC_904 1141-0088 396 µM 1.14428809823051 0.105869192932843 no 430 0.126252088752989 644 1378119
SGTC_2153 5569715 200 µM 1.14328315982466 0.106050235784278 no 431 0.126460522291042 651 2054701
SGTC_924 2046-0044 21.3 µM 1.14049184109652 0.106554274042458 no 432 0.127040724952703 678 3623589
SGTC_2968 9090663 33.37 µM 1.13752052860258 0.107092712178951 no 433 0.127660373887172 674 25236811
SGTC_657 3534-0529 86.7 µM 1.13519172726628 0.10751608905777 no 434 0.128147497479608 688 1049549
SGTC_188 3229-0966 278.469 µM 1.13125555167325 0.108234427105979 no 435 0.128973773275367 786 5722370
SGTC_52 0329-0193 875 nM 1.12925066774683 0.108601636285869 no 436 0.129396052562622 674 3739292
SGTC_2591 skatole 100 µM 1.12584384034108 0.10922767526647 no 437 0.130115811934651 663 6736 A reactive methylindole and nucleophilic thiol agent. Glutathione protects alkylation of proteins by a skatole metabolite.
SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100 µM 1.12469035793502 0.109440225764723 no 438 0.130360134486029 612 6857784
SGTC_3316 9136639 10.545 µM 1.12353099007411 0.109654159945654 no 439 0.130606023252764 670 4903665
SGTC_638 3970-0837 4.09 µM 1.12024551536466 0.110262047939832 no 440 0.131304576485598 694 4118451 YLR208W SEC13
SGTC_1897 st060201 15 µM 1.11818096271563 0.110645271817027 no 441 0.131744856632369 648 611878
SGTC_308 4092-1169 104 µM 1.11752363843578 0.110767484975048 no 442 0.131885249131011 728 2268590 YDL196W YDL196W
SGTC_1319 1306-0155 43.7 µM 1.1158048181139 0.111087514082974 no 443 0.132252845485352 739 3122360
SGTC_1254 0550-0035 264 µM 1.11410364559049 0.111404908786037 no 444 0.132617362430274 740 15121435
SGTC_2732 terfenadine 20 µM 1.11390444893908 0.111442116125799 no 445 0.132660090304242 640 5405 A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity.
SGTC_1697 st025554 27.742 µM 1.11272261768337 0.111663049726524 no 446 0.132913789271305 645 1269519
SGTC_1425 4048-4433 7.33 µM 1.11229314265085 0.111743414113375 no 447 0.133006065649556 747 23734946
SGTC_1438 4092-1045 4 µM 1.1047777656403 0.113156410389169 no 448 0.134627948566148 715 1351342
SGTC_1809 st050081 57.6 µM 1.10218861967794 0.113646146264013 no 449 0.135189839242784 703 5036894
SGTC_1592 4',5'-dihydroxyflavone 8.85 µM 1.10102883777669 0.113866007844651 no 450 0.135442053217543 720 688669
SGTC_140 0062-0056 502.533 µM 1.09509971886195 0.114994735587851 no 451 0.136736475924318 749 3758964
SGTC_3121 9125696 49.47 µM 1.09193413828722 0.115600615875117 no 452 0.137431025585271 693 1235365
SGTC_2332 7982454 138.89 µM 1.09164250740458 0.115656546809024 no 453 0.137495132324759 728 2981748
SGTC_1772 st048439 82.2 µM 1.09130063802584 0.1157221372917 no 454 0.137570308555564 719 2927068 YDL195W SEC31
SGTC_1225 1216-0074 20.6 µM 1.09026954041497 0.115920121935278 no 455 0.13779721426976 716 4241466
SGTC_1360 1598-0022 39.8 µM 1.09010847312296 0.115951070732362 no 456 0.137832682155932 794 761525
SGTC_2558 carylophyllene oxide 100 µM 1.08973151048992 0.116023526370007 no 457 0.137915715705649 754 6708694 An oxygenated terpenoid and antifungal agent.
SGTC_3099 9120367 49.47 µM 1.08840214903989 0.116279298209276 no 458 0.138208806428035 710 24824940
SGTC_634 1611-4317 11.2 µM 1.08696027850069 0.116557169045789 no 459 0.138527182342771 779 2843522
SGTC_2978 9011784 42.97 µM 1.08619889876455 0.116704088587146 no 460 0.138695502203072 823 2994934
SGTC_1303 1160-0052 261 µM 1.08191196514151 0.117533767245678 no 461 0.139645823841753 720 3562476
SGTC_3311 9131146 2.8755 µM 1.0799844616764 0.117908167465461 no 462 0.140074549779912 717 4900406 YPR165W RHO1
SGTC_762 1165-0429 115 µM 1.07970496230694 0.117962527675357 no 463 0.140136791729493 717 5967793
SGTC_1426 4048-4480 71.7 µM 1.07608781233301 0.118667631873775 no 464 0.140943992915926 742 14224343
SGTC_1213 1315-0166 115 µM 1.07519372488142 0.118842377647783 no 465 0.141144002149117 616 768401
SGTC_418 lividomycin a 100 µM 1.07489423907679 0.118900951552369 no 466 0.141211040757995 773 72394 An antibiotic.
SGTC_826 1683-5028 118 µM 1.07429452503535 0.11901830585322 no 467 0.141345349053509 728 722377
SGTC_770 0389-1121 67.2 µM 1.07359389967689 0.119155510416717 no 468 0.141502366463326 773 6753108
SGTC_66 0109-0187 42.4 µM 1.07348780572806 0.119176296691237 no 469 0.141526153517656 669 759417
SGTC_2452 5863136 48.41 µM 1.070146749711 0.119832197251376 no 470 0.142276629468485 716 2184096
SGTC_120 rhodamine 6G 52.259 µM 1.06598107006757 0.120653543563755 no 471 0.143216099604976 885 65211 Rhodamine 6G is a noncompetitive inhibitor of F0F1-ATPase
SGTC_724 3910-0327 137 µM 1.06493555826286 0.120860307678872 no 472 0.143452546248361 752 2885483
SGTC_1607 st000305 50.6 µM 1.06455976210682 0.120934687345649 no 473 0.143537598393094 748 5457690
SGTC_2786 7743617 45.45 µM 1.06156754576129 0.121528072834304 no 474 0.144216026824873 649 583674
SGTC_2127 5253358 187.912 µM 1.0614013969585 0.121561081621953 no 475 0.144253761167117 659 20612
SGTC_2416 tofa 880 nM 1.05725310700385 0.122387265987624 no 476 0.145198044167901 667 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2940 9060638 45.86 µM 1.05385565878506 0.12306684005049 no 477 0.145974503213606 746 4027022
SGTC_476 mead acid 10 µM 1.05360735063825 0.123116611370164 no 478 0.146031361213374 681 5312531 An omega 9 fatty acid.
SGTC_1833 st055984 71 µM 1.05133002452731 0.123573740706621 no 479 0.146553520974192 748 676288
SGTC_1190 1486-1332 13 µM 1.04862869310177 0.124117520540008 no 480 0.147174522303175 753 4150046
SGTC_592 k241-0073 46.5 µM 1.04538498773235 0.124772689909831 no 481 0.147922536109091 800 4230158
SGTC_2207 7258803 200 µM 1.04412935786668 0.12502695194164 no 482 0.14821277237706 706 3666799
SGTC_1294 1000-1494 117 µM 1.04382211584891 0.125089222786659 no 483 0.148283848720998 740 712797 YDL207W GLE1
SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 100 µM 1.04326245956595 0.125202707817457 no 484 0.148413376326679 804 23847180
SGTC_2005 4024620 188 µM 1.03943491199551 0.125980770948666 no 485 0.149301257155028 764 236743
SGTC_560 2332-1943 155 µM 1.0381292786061 0.126246949422453 no 486 0.149604936059993 765 21177716
SGTC_329 k048-0121 21.3 µM 1.0378463797418 0.126304675423286 no 487 0.149670790151771 730 6832902
SGTC_1023 4482-3888 16 µM 1.03771185484675 0.12633213191202 no 488 0.149702112066195 767 3303168
SGTC_1606 st000094 49.2 µM 1.03437724028195 0.127014055318576 no 489 0.150479920082013 826 1242210
SGTC_2133 5320837 200 µM 1.03266030777595 0.127366162624009 no 490 0.15088144737069 715 2841355
SGTC_2504 purpurogallin 52.29 µM 1.03220243089288 0.127460178252208 no 491 0.150988648258981 735 5281571 An antioxidant.
SGTC_985 1493-0307 8.71 µM 1.03209912318619 0.127481397042191 no 492 0.151012842287128 731 3278274
SGTC_3112 9123419 49.47 µM 1.03185606593604 0.12753132924693 no 493 0.151069774971955 805 17015854
SGTC_1971 st069429 63.5 µM 1.03176290508586 0.127550471250521 no 494 0.151091600354527 748 1246522 YGL099W LSG1
SGTC_975 1335-0046 28.5 µM 1.03067681394087 0.127773780647292 no 495 0.151346200611337 759 16486740
SGTC_2146 5545642 200 µM 1.03013283633075 0.127885729050502 no 496 0.15147382640611 774 825326
SGTC_2430 5571206 200 µM 1.03007229255364 0.127898192929821 no 497 0.151488035362709 860 1731771
SGTC_18 0111-0177 500 nM 1.02500662156407 0.128944031163557 no 498 0.15268003166108 868 721752
SGTC_679 0422-0091 41.4 µM 1.0241547424566 0.129120487643571 no 499 0.152881095669145 818 627384 YHR062C RPP1
SGTC_1919 st067113 52.3 µM 1.02316454675528 0.129325805050554 no 500 0.15311502627997 765 1268243
SGTC_346 4513-0042 7.16 µM 1.02195932032919 0.129576014312225 no 501 0.153400077176697 805 2827372
SGTC_42 0133-0086 60.653 µM 1.02167800502723 0.129634464601533 no 502 0.153466662280677 705 162923 Model of phenazepam hydroxylation.
SGTC_919 tnp00227 403.569 nM 1.02096177495107 0.129783361743062 no 503 0.153636274668082 813 1269246 A methoxyflavone. YNL221C POP1
SGTC_2232 chlorophetanol 41.5365 µM 1.01622170343053 0.130771760963144 no 504 0.154761911739037 906 15907 An antifungal of unknown mechanism. YFR051C RET2
SGTC_1200 1643-0193 18.4 µM 1.01414166281768 0.131207129209659 no 505 0.155257580183939 835 5403974
SGTC_1627 st003713 25.6 µM 1.01311306752147 0.131422791504025 no 506 0.155503078628304 845 16195070 YER133W GLC7
SGTC_2458 5808907 16.39 µM 1.01097334982117 0.131872203022926 no 507 0.156014592613665 858 2731747
SGTC_3213 9129884 49.47 µM 1.01090219420689 0.131887166247621 no 508 0.156031621874779 699 17190742
SGTC_854 0422-0053 192 µM 1.01008075684704 0.132059990080929 no 509 0.156228300418845 770 3596728
SGTC_2358 9037157 4 µM 1.01003744684229 0.132069106490657 no 510 0.156238674758715 787 2388925
SGTC_1118 chelidonine 707.474 nM 1.00980901768738 0.132117196181892 no 511 0.156293399456306 854 10147 Benzophenanthridine derived from scoulerine from Chelidonium majus; putative GST and MDR inhibitor.
SGTC_1902 st060212 70.5 µM 1.00503402532518 0.133125208682894 no 512 0.157440233103127 805 688944
SGTC_3066 9117245 49.47 µM 1.00446331224599 0.133246040785986 no 513 0.157577673193844 825 17176980
SGTC_2595 hexamethylquercetagetin 100 µM 1.00349631628401 0.133450946622107 no 514 0.157810726696654 736 386331
SGTC_119 0121-0043 24.815 µM 1.00343560519445 0.133463818490758 no 515 0.157825366087162 963 1092378
SGTC_1484 3473-2379 286 µM 1.00256327298027 0.133648863267853 no 516 0.158035811828809 932 671917
SGTC_2903 5923464 63.88 µM 1.00158738902357 0.133856083082653 no 517 0.158271457118591 782 2876576
SGTC_2912 7964298 10.93 µM 1.00040589236701 0.134107258207104 no 518 0.158557059793505 844 2975850
SGTC_782 0083-0095 30.5 µM 1.0003893176816 0.134110784131506 no 519 0.158561068787511 838 3591729 An indicator and reagent.
SGTC_2214 7179297 48.276 µM 0.999434939030792 0.134313916032134 no 520 0.15879202077346 808 769744
SGTC_686 1319-0111 510 µM 0.99874288176239 0.134461347007787 no 521 0.158959630940933 842 4562600
SGTC_2986 9022445 71.43 µM 0.998445932532901 0.134524641018266 no 522 0.159031584957162 805 6459286
SGTC_496 calpeptin 138 µM 0.993692231316244 0.135540665735225 no 523 0.160186363017035 711 73364 A calpain inhibitor.
SGTC_3237 9133362 49.47 µM 0.993661071738292 0.135547342876553 no 524 0.160193950398238 814 43845137
SGTC_2359 9039622 200 µM 0.99078692010584 0.136164210036351 no 525 0.160894818742269 850 6463596
SGTC_2182 6325192 200 µM 0.988743229475225 0.136604005868629 no 526 0.161394393172568 777 736248
SGTC_10 0279-0212 42.575 µM 0.985831266467376 0.137232327657295 no 527 0.162107960010554 920 39851 YBR002C RER2
SGTC_1222 0366-0074 1.18 µM 0.985332966730551 0.137340044560838 no 528 0.162230272259105 876 286520
SGTC_2210 7115885 190.385 µM 0.985312055140193 0.137344566258236 no 529 0.162235406514409 843 2927039
SGTC_509 pifithrin 175 µM 0.984885621683608 0.137436795817034 no 530 0.162340128380215 874 4817 A p53 inhibitor.
SGTC_866 0495-0101 262 µM 0.984862451198162 0.137441808369441 no 531 0.162345819757786 761 635694
SGTC_1398 3558-0053 112 µM 0.982918711087683 0.137862748966427 no 532 0.162823724014177 750 4532369
SGTC_1692 fluoroquinolonic acid 71 µM 0.981916959655044 0.138080033540808 no 533 0.16307037991305 799 483180 Also called cipro. Inhibits gyrases and topoisomerase 1 and 2
SGTC_1785 bathophenanthroline 24 µM 0.981362261020798 0.138200450681673 no 534 0.163207064811982 785 72812 An iron chelator.
SGTC_1275 0867-0008 21.1 µM 0.980031984277547 0.138489526418201 no 535 0.163535165428162 820 3422836
SGTC_2939 9044578 71.43 µM 0.978046305497421 0.138921790339406 no 536 0.164025711265937 781 2653634
SGTC_2965 9082772 38.63 µM 0.977112079091255 0.139125480242693 no 537 0.16425683419752 855 16459634
SGTC_2690 usnic acid 100 µM 0.973374349815709 0.13994245231567 no 538 0.16518364118798 886 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_2945 9067681 61.76 µM 0.970551791344382 0.140561547893974 no 539 0.165885761205902 810 16456930
SGTC_2662 daunorubicin 22.37 µM 0.967800930239752 0.141166703834266 no 540 0.166571899573277 795 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_2639 lactacystin 53 µM 0.966551175442425 0.141442217405199 no 541 0.166884226147585 870 3870 A proteasome inhibitor.
SGTC_2449 5812982 45.77 µM 0.964115658013935 0.141980183648837 no 542 0.167493971647267 787 776185
SGTC_1508 1080-0625 72.9 µM 0.961904260340292 0.142469843878007 no 543 0.168048849157656 793 767111
SGTC_311 1315-0136 58 µM 0.961354129684129 0.142591834140931 no 544 0.168187069890156 845 6759207
SGTC_777 1315-0167 517 µM 0.957573832147521 0.143432016886751 no 545 0.169138849830592 800 4221767
SGTC_2508 celastrol 40.54 µM 0.953387699359491 0.144366290251972 no 546 0.170196835725842 803 122724 Celastrol is a natural product and antioxidant.
SGTC_457 grayanotoxin iii 135 µM 0.94786878625864 0.145604272536154 no 547 0.171598128548748 884 46864190 Grayanotoxin III activates Na+ ion channels affecting their polarization state. This produces an effect on the voltage-dependent Ca2+ channels, increasing influx of Ca2+, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.
SGTC_3024 9090631 49.47 µM 0.94715765127857 0.145764309322685 no 548 0.17177922559812 821 25236383
SGTC_2105 5350118 200 µM 0.947014958987273 0.145796435629179 no 549 0.171815578198354 866 2133313
SGTC_2000 st075254 36.4 µM 0.946850281246629 0.145833517741792 no 550 0.17185753796618 836 17234175
SGTC_2431 5490079 200 µM 0.944968605058264 0.146257683361577 no 551 0.17233745217778 874 5722345
SGTC_3053 9095903 49.47 µM 0.942812333076862 0.146744765818836 no 552 0.172888451132377 893 17174018
SGTC_1277 0873-0036 22 µM 0.94187920862948 0.146955887258166 no 553 0.173127242984985 893 5965735
SGTC_1093 fluphenazine 7.97 µM 0.93926304109742 0.147548886593529 no 554 0.173797854607419 886 6602611 An atypical antipsychotic.
SGTC_426 0988-0037 14.6 µM 0.936501447506703 0.148176586086634 no 555 0.174507533821286 910 5383008
SGTC_1898 st060199 18.6 µM 0.936495938892001 0.148177839956289 no 556 0.174508951271653 844 688866
SGTC_2258 7960471 200 µM 0.933227814976032 0.148922981213088 no 557 0.175351178141421 761 2974708
SGTC_3079 9117512 49.47 µM 0.931798288297728 0.149249702960681 no 558 0.175720389709227 944 7185044
SGTC_2729 fluphenazine 10.66 µM 0.928550349663776 0.149993805014091 no 559 0.176561081474765 897 3372 An atypical antipsychotic.
SGTC_231 b-estradiol 524 µM 0.927353913090964 0.15026853075307 no 560 0.176871405431884 809 450 A steroid.
SGTC_210 3551-0445 56.827 µM 0.927204097673477 0.150302954975035 no 561 0.176910287854044 870 2865180 YOR207C RET1
SGTC_2655 perillic acid 100 µM 0.92414639008189 0.151006695753163 no 562 0.177705051558671 843 5702197 An apoptosis inducer.
SGTC_55 0767-0285 6.563 µM 0.924072432826724 0.151023744358344 no 563 0.177724302494192 940 3116166
SGTC_273 hydroxyurea 18.1 mM 0.923532963865587 0.151148141334685 no 564 0.177864765057883 954 3657 Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. YDR047W HEM12
SGTC_1912 st060209 90.8 µM 0.923141886472388 0.151238363081789 no 565 0.177966634390827 820 688787
SGTC_1944 st076371 56.9 µM 0.922557923103025 0.151373150389371 no 566 0.178118815869677 833 24208455
SGTC_1665 st014639 11.4 µM 0.91991805843964 0.151983466437936 no 567 0.178807790628611 933 981133 YIL048W NEO1
SGTC_1690 st023502 41.2 µM 0.919176598020688 0.152155179890104 no 568 0.179001604757112 870 24207482
SGTC_337 1315-0038 354 µM 0.918645095159863 0.15227834889804 no 569 0.179140618315855 869 1626437
SGTC_613 3914-0030 117 µM 0.917441917891281 0.152557414331517 no 570 0.179455557822481 673 1145395
SGTC_626 0214-0009 33 µM 0.917310233037197 0.15258797795964 no 571 0.179490048312477 926 3437874
SGTC_2538 3',7'-epoxycaryophyllan-6-one 100 µM 0.916785736308733 0.15270975226355 no 572 0.179627464220535 863 4330530
SGTC_2679 rapamycin 1 nM 0.914755317450861 0.153181769602053 no 573 0.18016004841396 954 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YHR036W | YHR186C | YKL203C BRL1 | KOG1 | TOR2
SGTC_2749 bexarotene 57.39 µM 0.9110437488997 0.154047105254747 no 574 0.181136161502051 858 82146 An retinoic acid receptor inhibitor.
SGTC_232 clozapine 119 µM 0.907044042012925 0.154983232657789 no 575 0.1821917538 889 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_287 k060-0039 29.6 µM 0.904999369088429 0.15546323444526 no 576 0.182732860716408 930 5861974
SGTC_3110 9122132 49.47 µM 0.904974902551531 0.155468984074382 no 577 0.182739341665418 934 918317
SGTC_2307 7538926 6.34 µM 0.903548695798532 0.155804384701394 no 578 0.183117378005644 903 96582
SGTC_2489 cantharidin 73.42 µM 0.90328779540593 0.155865792152438 no 579 0.183186586105102 890 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 92.62 µM 0.901360869078993 0.1563198218678 no 580 0.183698239930172 859 6708760
SGTC_653 0203-0016 55.2 µM 0.900593008131506 0.156500990683426 no 581 0.18390237673868 916 295302
SGTC_2611 pyromycin 23.93 µM 0.900453415436894 0.156533940975378 no 582 0.183939502804188 878 196990 An antibiotic that causes premature chain termination during translation. Part of the molecule resembles the 3' end of the aminoacylated tRNAs. It will enter the A site and transfer to the growing chain, causing premature chain release.
SGTC_399 oxolinic acid 75 µM 0.899585730800617 0.156738856859193 no 583 0.184170376818977 891 4628 A DNA gyrase inhibitor.
SGTC_875 0709-0210 25.7 µM 0.895640295724746 0.157672852209297 no 584 0.185222453511817 986 6251364
SGTC_2239 6685329 187.64 µM 0.89443609279747 0.157958647668672 no 585 0.185544304260956 884 805680
SGTC_1188 1403-0014 4.57 µM 0.894256835376369 0.158001220192742 no 586 0.185592244563846 954 9614867
SGTC_1797 st048695 56.8 µM 0.892911565827531 0.158320953727002 no 587 0.185952266430328 919 592262 YIL048W NEO1
SGTC_2628 lathosterol 100 µM 0.892635732503623 0.158386564122067 no 588 0.186026138577368 930 6710616
SGTC_1055 3448-0672 86 µM 0.891956337107465 0.158548242850237 no 589 0.186208168054346 883 748378
SGTC_283 0987-0079 11.7 µM 0.889027738577893 0.159246412818937 no 590 0.186994086185456 960 411556
SGTC_2686 alizarin 95.37 µM 0.888318474318132 0.159415801909717 no 591 0.187184732450643 865 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium. YHR062C RPP1
SGTC_1273 0849-0096 14.1 µM 0.885166440503791 0.160170008641683 no 592 0.188033434739838 916 5286025
SGTC_1456 k015-0012 13 µM 0.8843191419747 0.160373144178478 no 593 0.188261978943746 1004 2989616
SGTC_1818 st052136 56.3 µM 0.883391551073064 0.160595722357093 no 594 0.188512377060688 885 674169
SGTC_445 e6 berbamine 66 µM 0.880203878128798 0.161362151279815 no 595 0.189374436490946 1010 6610268 A calcium/calmodulin antagonist.
SGTC_2349 9023730 187.07 µM 0.879589623728028 0.161510113369999 no 596 0.189540830993938 927 4126287
SGTC_3349 9149703 23.001 µM 0.878693413469676 0.161726151848278 no 597 0.18978376543161 961 4910494
SGTC_1578 josamycin 24.2 µM 0.877891902260109 0.161919521840867 no 598 0.190001192053271 861 5282165 A P450 substrate.
SGTC_1765 st044815 90.4 µM 0.876619800179421 0.162226734168752 no 599 0.190346590452031 920 645695
SGTC_168 3970-0862 530.542 µM 0.876318495915618 0.1622995546235 no 600 0.190428456387793 1042 3135186
SGTC_1982 st072467 71.9 µM 0.875890813841447 0.162402955120642 no 601 0.190544696953279 962 3163533
SGTC_1565 sinapyl alcohol 95.1 µM 0.873975331737743 0.162866586254934 no 602 0.191065843932204 916 5280507 A phenol propionate derived from cinnamic acid.
SGTC_1060 3448-7350 82 µM 0.872101408189064 0.163320990409645 no 603 0.191576529003029 923 570178
SGTC_2517 totarol 10 µM 0.871157959632545 0.163550076877363 no 604 0.191833955477727 885 460178 An antibacterial membrane disruptor. YGL001C ERG26
SGTC_2003 4023581 200 µM 0.871032305714496 0.163580603672535 no 605 0.191868256993585 918 16641307
SGTC_1963 st076565 50.3 µM 0.870406970550948 0.163732579767162 no 606 0.192039019354277 934 4914280
SGTC_2018 5133068 143 µM 0.869654608578709 0.163915548800044 no 607 0.192244592565168 880 785362
SGTC_3350 9150499 3.57 µM 0.867997000932135 0.164319135065673 no 608 0.19269798722698 993 4910996 YPR165W RHO1
SGTC_2955 9076254 12.21 µM 0.867988998669639 0.164321084979079 no 609 0.192700177617519 905 16459619
SGTC_1366 1683-0113 21.9 µM 0.86781975254435 0.164362328740974 no 610 0.192746507468457 945 708623
SGTC_694 1315-0438 43.2 µM 0.867447574530418 0.164453048787322 no 611 0.19284841233022 891 6793154
SGTC_392 N-ethylmaleimide 8.33 µM 0.867166505568636 0.164521582104362 no 612 0.192925392724519 916 4362 N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It contains the imide functional group, but more importantly it is an alkene that is reactive toward thiols and is commonly used to modify cysteine residues in proteins and peptides.
SGTC_3056 9094900 49.47 µM 0.867083519448851 0.164541820229159 no 613 0.192948124913466 945 25236784
SGTC_74 000s-0487 160.283 µM 0.866517821348691 0.164679822052029 no 614 0.193103128817875 1001 677548
SGTC_108 0509-0257 621.132 µM 0.865817774062475 0.164850702093327 no 615 0.193295050238236 963 536624
SGTC_1991 st073000 8.92 µM 0.864085027410662 0.16527415557169 no 616 0.19377059169365 990 4301969 YIL048W NEO1
SGTC_2194 5927483 104.545 µM 0.859477087707697 0.166403678485395 no 617 0.195038677826165 1013 760979
SGTC_50 0929-0078 56.389 µM 0.859386232804564 0.166425999316673 no 618 0.19506373133373 900 1377751
SGTC_525 k781-2675 26.7 µM 0.857477585704091 0.166895354127368 no 619 0.195590498531589 989 3651118 YDL195W SEC31
SGTC_1287 0971-0001 34.6 µM 0.856928529483337 0.167030530353205 no 620 0.195742192293533 996 4665869
SGTC_574 1315-0397 40 µM 0.85666542271052 0.167095331577914 no 621 0.195814908978821 1061 6794277
SGTC_1727 st034309 9.9045 µM 0.856116912847251 0.167230477557616 no 622 0.195966557246231 1024 870305
SGTC_2304 7443016 91.4 µM 0.853951415298507 0.167764717065049 no 623 0.196565954834968 892 939854
SGTC_1638 st008370 60.6 µM 0.85363453059059 0.167842986243293 no 624 0.196653759818199 953 24207134
SGTC_1372 2752-0194 270 µM 0.845859391107559 0.169770774975713 no 625 0.198815594424208 909 823334
SGTC_1632 st005650 90 µM 0.842380871313117 0.170637827653858 no 626 0.199787398348145 940 2759605
SGTC_2528 xanthyletin 44.79 µM 0.84120396932718 0.170931821852201 no 627 0.200116838610563 973 65188 An natural product with antifungal activity of unknown mechanism.
SGTC_1007 4101-0031 70 µM 0.840619855104415 0.171077855873415 no 628 0.200280465961377 1002 1146276
SGTC_1444 4112-3581 28 µM 0.833202642711388 0.172939164758121 no 629 0.202365226208219 1004 2877249
SGTC_3231 9132313 49.47 µM 0.832569964235734 0.173098527030608 no 630 0.202543652220841 982 4905967
SGTC_2993 9054257 71.4286 µM 0.829918535270359 0.173767399428793 no 631 0.203292422236195 1053 6470217 YGL055W OLE1
SGTC_2887 9044784 58.44 µM 0.829179733381649 0.173954068467032 no 632 0.20350135560286 1069 6465546
SGTC_412 gemfibrozil 100 µM 0.82869979781285 0.174075399458204 no 633 0.203637150109101 971 3463 A peroxisome proliferator-activated receptor activator which lowers lipid levels.
SGTC_942 3253-1115 227 µM 0.823896626481703 0.17529263598597 no 634 0.204999148720086 1012 46497897
SGTC_2633 5,7-dihydroxyisoflavone 100 µM 0.821207540862825 0.175976464385215 no 635 0.205764030970042 983 5377381
SGTC_2051 5263410 176 µM 0.817810820079578 0.176842653688694 no 636 0.206732609370691 1074 227584
SGTC_320 4092-0846 5.34 µM 0.81778146641928 0.176850150817923 no 637 0.206740991344723 1025 1359356
SGTC_2731 amoxapine 43.43 µM 0.816171444416208 0.17726166930979 no 638 0.207201043236307 1016 2170 A moderate and strong reuptake inhibitor of serotonin and norepinephrine.
SGTC_1343 1487-0095 224 µM 0.815134373139208 0.17752706266108 no 639 0.207497699040324 1017 4560101 YGL055W OLE1
SGTC_779 1360-0071 233 µM 0.812931763709694 0.178091556332415 no 640 0.208128590933175 1089 7566
SGTC_422 cantharidin 155 µM 0.811878008149791 0.178362016813766 no 641 0.208430817327717 995 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2698 st077697 67.5 µM 0.808528693963987 0.179223380517128 no 642 0.209393147353887 970 3154499
SGTC_3120 9124077 49.47 µM 0.808119767364456 0.179328725604157 no 643 0.209510819591244 1105 18774327 YGL155W CDC43
SGTC_1526 st051518 75 µM 0.807318820995834 0.179535173136043 no 644 0.209741411661018 926 673993
SGTC_2949 9072542 2.23 µM 0.807184881389488 0.179569711245761 no 645 0.209779987366642 1070 16457352
SGTC_896 0964-0007 44.5 µM 0.807080375201123 0.17959666245699 no 646 0.209810088903091 1069 6756758
SGTC_2997 9067075 71.4286 µM 0.805606426923819 0.17997705126346 no 647 0.210234909339475 1032 27209819
SGTC_3244 9134489 49.47 µM 0.804444979212135 0.180277147691605 no 648 0.210570016642807 1028 16584271
SGTC_241 5hr heat shock (37°C) + cantharidin 155.449 µM 0.803243745296738 0.180587854265047 no 649 0.210916932802649 1036 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_2022 5136654 200 µM 0.798287858590954 0.181873272815692 no 650 0.212351731083292 1011 1713771
SGTC_3179 9107801 49.47 µM 0.797850613735726 0.181986955980772 no 651 0.212478592788615 1073 4818259
SGTC_2842 9000675 19.48 µM 0.796657367774464 0.182297424599311 no 652 0.212825024962642 1015 2989072
SGTC_2979 9012552 45.46 µM 0.794624662847355 0.182827072227019 no 653 0.213415933799104 1014 17100905
SGTC_160 3453-0671 289.699 µM 0.793844517144075 0.183030604116461 no 654 0.2136429764449 1089 5322268
SGTC_369 0957-0393 4.5 µM 0.792619811298707 0.183350402148399 no 655 0.213999681326727 1042 6997992
SGTC_2459 5811157 9.22 µM 0.789378337821286 0.18419850320166 no 656 0.214945456440333 1073 2870684 YBR192W RIM2
SGTC_908 3448-7491 47.7 µM 0.788629877188504 0.184394677309291 no 657 0.215164181679142 1093 1203031
SGTC_1964 st076914 61 µM 0.784992988899844 0.185349767396792 no 658 0.216228839647984 1105 24208661
SGTC_474 dl-dihydrosphingosine 5 µM 0.77812064997555 0.187162892058604 no 659 0.218248945017177 1110 3058739 A sphingolipid protein kinase C inhibitor.
SGTC_2378 9074213 121.43 µM 0.774117883695608 0.18822397660248 no 660 0.219430541334142 1101 657714
SGTC_2078 5212016 200 µM 0.772436998999423 0.188670663094533 no 661 0.219927823676206 1039 1899708
SGTC_2223 6903751 107.57 µM 0.770535053692145 0.189176882607292 no 662 0.220491284917301 1028 5598863
SGTC_2435 5706476 10.6 µM 0.76982088807257 0.189367179865618 no 663 0.220703073664073 1117 5725375
SGTC_3356 9151811 4.48 µM 0.767833281273812 0.189897419457981 no 664 0.221293119626764 1056 1859254 YPR165W RHO1
SGTC_25 0118-0223 35.662 µM 0.767399656085375 0.190013220078144 no 665 0.221421966475754 1093 5333628
SGTC_2377 9073351 62.6 µM 0.766778870631959 0.190179077813963 no 666 0.221606500531015 1068 7337946 YHR072W ERG7
SGTC_342 k048-0088 23.3 µM 0.766558269871921 0.190238038017599 no 667 0.221672097249381 1093 6820570
SGTC_347 4534-1311 26.2 µM 0.765591492357266 0.190496562112655 no 668 0.221959704109927 1110 2862016
SGTC_14 0354-0009 295 µM 0.764639358608541 0.190751381074413 no 669 0.222243162732746 1110 1713507
SGTC_349 k015-0014 24 µM 0.76401413404586 0.190918823254906 no 670 0.222429409901894 1048 2196908
SGTC_3088 9117578 49.47 µM 0.763925353270122 0.190942607055199 no 671 0.222455863884529 1153 678341
SGTC_2293 7624732 200 µM 0.763092749733624 0.19116574463734 no 672 0.222704041827579 1093 894453
SGTC_2184 6075246 200 µM 0.761335418701518 0.191637233555924 no 673 0.223228375224571 1057 2267320
SGTC_2711 st079103 59.1 µM 0.759799317356864 0.192049949772517 no 674 0.223687275515706 1092 54693780
SGTC_2234 tolnaftate 200 µM 0.756925299859869 0.192823593681065 no 675 0.22454730853209 1075 5510 Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. YAR007C | YGR099W | YAL001C | YER082C RFA1 | TEL2 | TFC3 | UTP7
SGTC_783 0848-0141 92.7 µM 0.756724380587432 0.192877749348209 no 676 0.224607502535992 1048 6755076 YHR007C | YLR033W ERG11 | RSC58
SGTC_2783 7738165 71.43 µM 0.755687692675115 0.193157325233934 no 677 0.224918232382272 1040 17201110
SGTC_1302 1159-0335 255 µM 0.754611124637287 0.193447917755626 no 678 0.225241173383876 1095 649284
SGTC_1705 st027868 56.3335 µM 0.753906864930682 0.19363815921046 no 679 0.225452574072703 1131 292948
SGTC_299 1273-0059 1.44 µM 0.752779893520451 0.193942824900491 no 680 0.225791095525392 1077 2848077
SGTC_1532 4',5'-dihydroxyflavone 78.7 µM 0.75239617041137 0.194046627315761 no 681 0.225906424456214 1145 165521
SGTC_2570 licareol 100 µM 0.751062022999211 0.194407796022041 no 682 0.226307664893303 1042 443158
SGTC_1591 genipin 88.4 µM 0.749683259029903 0.194781472607465 no 683 0.2267227462679 1056 442424 A DNA cross-linking agent.
SGTC_768 0384-0033 77.3 µM 0.748949323501069 0.194980563988914 no 684 0.226943875036273 1072 3965305 YMR134W ERG29
SGTC_914 3820-6779 408 µM 0.746965340321253 0.195519369123778 no 685 0.22754224134287 1139 2893481
SGTC_447 ml7 120 µM 0.746831751963634 0.195555681173982 no 686 0.227582563287846 1153 4216 Selective myosin light chain kinase inhibitor.
SGTC_3308 9128332 17.569 µM 0.741252661360237 0.197075846719853 no 687 0.229270129321423 1146 17332805 YDL196W YDL196W
SGTC_2421 5690543 90.72 µM 0.739815277910407 0.197468654075615 no 688 0.229706043697462 1106 3397993
SGTC_69 0096-0274 206.684 µM 0.739154815276072 0.197649303566466 no 689 0.229906497326237 1280 6741392
SGTC_23 0213-0011 39.996 µM 0.739061564341002 0.197674817571835 no 690 0.229934807326108 1125 627608
SGTC_1679 SEC14.276 6.7 µM 0.738821413427936 0.197740533440327 no 691 0.230007723591537 1159 1005053 YMR079W SEC14
SGTC_1385 3091-4834 14.1 µM 0.737371415602726 0.198137597142309 no 692 0.230448256700118 1076 4072814
SGTC_1770 st043884 66.3 µM 0.736934863951518 0.198257235548434 no 693 0.230580980567661 1146 670149
SGTC_636 0kpi-0074 126 µM 0.73690641871812 0.198265032570412 no 694 0.230589630193413 1102 616434
SGTC_2346 9031566 143.75 µM 0.736340614972448 0.198420161479197 no 695 0.23076171744707 1100 4771086
SGTC_3008 9078912 71.4286 µM 0.735900338746949 0.19854092460573 no 696 0.230895675551832 1125 16648731
SGTC_2623 humulene 100 µM 0.735606744136505 0.198621479146215 no 697 0.23098502854747 1053 6187145 An anti-inflammatory.
SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 100 µM 0.735249096750431 0.198719634688979 no 698 0.231093901529164 1096 521171
SGTC_2911 7942208 15.64 µM 0.735083940079356 0.198764971446108 no 699 0.231144187247467 1114 1243384
SGTC_70 0141-0289 43.283 µM 0.730124052446608 0.200129402113522 no 700 0.232657180189684 1204 352408
SGTC_1934 st074720 32.6 µM 0.729433211628963 0.200319893302829 no 701 0.232868354195057 1180 17250992
SGTC_2990 9074105 71.4286 µM 0.7290101979149 0.200436588089232 no 702 0.232997712215884 1121 6502001
SGTC_2200 6600604 21.907 µM 0.727072040342843 0.200971780339118 no 703 0.233590912775319 1120 2904777
SGTC_1108 betulinic acid 729.144 nM 0.726108980342067 0.201238032999468 no 704 0.233885982085837 1170 64945 Apoptosis-inducing agent of unknown mechanism.
SGTC_605 1315-0399 119 µM 0.726025888131976 0.201261015017764 no 705 0.233911450154628 1174 24020461
SGTC_551 k048-0028 34.9 µM 0.725161351418158 0.201500225826782 no 706 0.234176524987418 1159 6836383
SGTC_649 1123-0311 367 µM 0.723903660616197 0.201848523449619 no 707 0.234562441238955 1139 693629 YIL048W NEO1
SGTC_2031 5180455 200 µM 0.722621963785856 0.202203839753992 no 708 0.234956085265159 1148 29949
SGTC_671 0560-0003 407 µM 0.721747999286598 0.202446337556849 no 709 0.235224712757732 1097 3238678
SGTC_1240 0356-0016 42.1 µM 0.721467329067728 0.202524251634369 no 710 0.235311017369592 1119 4305613
SGTC_3228 9131799 49.47 µM 0.71700466714603 0.20376549387466 no 711 0.236685608445 1110 17015818
SGTC_2712 st079126 47.7 µM 0.715794492441404 0.204102871205606 no 712 0.237059126846196 1141 3152970
SGTC_2926 9010726 65.15 µM 0.715665832823596 0.204138759004779 no 713 0.237098856463169 1164 2994293
SGTC_1338 1486-1223 76 µM 0.714808542477331 0.204377984087938 no 714 0.237363677956658 1168 3444526
SGTC_2235 salicylic acid 500 µM 0.713532070988874 0.204734489869482 no 715 0.237758287477346 1180 338 A COX inhibitor and kinase inhibitor.
SGTC_1030 k029-0042 36.7 µM 0.711686666978178 0.205250546264876 no 716 0.238329412905222 1169 6080581
SGTC_1326 1431-2094 10.8 µM 0.711461306536001 0.205313619895868 no 717 0.238399210097386 1157 616278
SGTC_1512 0259-0544 12.2 µM 0.710910955562755 0.205467699900113 no 718 0.23856970830974 1175 18476
SGTC_2559 tetrahydrosappanone a trimethyl ether 100 µM 0.71029578462279 0.20564000858791 no 719 0.238760366656245 1213 6708784 An antioxidant flavonoid
SGTC_2380 9035439 200 µM 0.709891163745303 0.205753389186731 no 720 0.238885815193917 1242 6462575
SGTC_106 0092-0003 11.579 µM 0.707594125052661 0.206397755269278 no 721 0.239598671122852 1133 1072148
SGTC_2661 dactinomycin 12.96 µM 0.7037670814157 0.207473970616374 no 722 0.240788918555753 1192 45006140 An Actinomycin D Classic transcription inhibitor.
SGTC_2460 5552655 174.22 µM 0.70366033900888 0.2075040354643 no 723 0.240822162528924 1186 5401989
SGTC_2270 7924575 90.91 µM 0.703360737799614 0.2075884342829 no 724 0.240915484000297 1166 1262135
SGTC_451 chloral hydrate 100 µM 0.70210024715506 0.20794374150238 no 725 0.241308324110707 1245 2707 Chloral hydrate is an aldehyde dehydrogenase (ALDH) inhibitor. YLR153C | YPL028W | YPR107C ACS2 | ERG10 | YTH1
SGTC_377 3970-0964 33.1 µM 0.698275595086022 0.209024030109212 no 726 0.242502429282259 1199 16481235
SGTC_1974 st069448 26.9 µM 0.697054868449715 0.20936952394286 no 727 0.242884228404037 1174 6323587 YNR016C ACC1
SGTC_2851 9015922 71.43 µM 0.696968022968262 0.209394116017636 no 728 0.242911402915441 1170 2996893
SGTC_2159 5658611 73.75 µM 0.694261191315043 0.210161462519916 no 729 0.243759212078283 1219 793844
SGTC_2418 pentamidine 31.67 µM 0.692813278633187 0.210572601391396 no 730 0.24421336898228 1193 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_123 0083-0120 66.675 µM 0.692779807125816 0.21058211129808 no 731 0.24422387315408 1153 16001701
SGTC_2779 methotrexate 400 µM 0.692439585466916 0.210678789192195 no 732 0.244330656791992 1268 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YGR267C FOL2
SGTC_278 4092-0821 23.9 µM 0.687718527350737 0.212023017546195 no 733 0.245815025218751 1205 877900
SGTC_2387 9077560 195.08 µM 0.687087261897716 0.212203137365534 no 734 0.246013870402054 1204 5303272
SGTC_2399 5884133 200 µM 0.685897155075858 0.212542955317983 no 735 0.246388982161883 1229 722445
SGTC_1414 3917-0015 5.4 µM 0.683709348484394 0.213168480719889 no 736 0.247079359543921 1198 6618702
SGTC_3234 9132280 49.47 µM 0.680187333354958 0.214177727897556 no 737 0.24819292581975 1221 17612295
SGTC_685 1278-0033 54.9 µM 0.676606030586334 0.215206809331789 no 738 0.249327975913416 1272 3590572
SGTC_720 r052-1644 49.9 µM 0.674490759476595 0.215815974727074 no 739 0.249999679274407 1215 1422863 YOR257W CDC31
SGTC_1415 3966-0071 78.1 µM 0.673632418932384 0.216063448298485 no 740 0.250272518543103 1223 2893185
SGTC_2724 maprotiline 69.64 µM 0.673463694051813 0.216112113755817 no 741 0.250326169399775 1212 4011 A tricyclic antidepressant.
SGTC_2470 5664817 21.68 µM 0.671758388417203 0.216604332682568 no 742 0.250868761708644 1263 2859561
SGTC_637 1181-0519 7.26 µM 0.671056400266543 0.216807142619389 no 743 0.251092300292847 1249 6252091 YGR060W ERG25
SGTC_2093 5331342 194.4 µM 0.669881507419051 0.217146824011655 no 744 0.251466664580645 1235 33839
SGTC_3158 9100007 49.47 µM 0.667578848880156 0.217813452583501 no 745 0.2522012313823 1242 19297233
SGTC_865 0488-0499 301 µM 0.666238629989882 0.218201993988883 no 746 0.252629292516556 1260 9634651
SGTC_2274 7947094 46.08 µM 0.664130100022686 0.218814083382986 no 747 0.253303523346164 1247 2971028
SGTC_166 k072-0058 166.424 µM 0.663325540815415 0.219047900650729 no 748 0.253561041109292 1257 5846229
SGTC_2148 5546263 113.568 µM 0.663149669561642 0.21909903066946 no 749 0.253617351080069 1239 792097
SGTC_1412 3909-8563 178 µM 0.662187583269479 0.219378853801567 no 750 0.253925505412989 1306 23767530
SGTC_479 n-linoleoylglycine 10 µM 0.661375200842909 0.219615295338883 no 751 0.254185862823766 1246 6433346 An anti-infammatory.
SGTC_478 N-arachidonylglycine 10 µM 0.661370492258139 0.219616666185188 no 752 0.254187372268467 1194 5283389
SGTC_1732 st034308 51.822 µM 0.660973427725155 0.219732284298504 no 753 0.254314677309172 1181 830119
SGTC_3017 9080681 49.47 µM 0.660488037873166 0.219873668628816 no 754 0.25447034620628 1251 16451914
SGTC_9 0092-0002 10.449 µM 0.660421848064196 0.219892952437332 no 755 0.254491577741969 1227 759368
SGTC_1980 st071811 45.7 µM 0.6597315120964 0.220094133487294 no 756 0.254713070353572 1295 4974850
SGTC_2571 chrysanthemic acid 100 µM 0.659210246515168 0.220246113161566 no 757 0.254880384005273 1202 2743 An insecticide.
SGTC_1344 1488-0097 29.1 µM 0.65651196562364 0.22103378256541 no 758 0.255747385603041 1253 747966
SGTC_2727 riluzole 51.77 µM 0.656352729255855 0.221080316415364 no 759 0.255798598912109 1253 5070 Riluzole is a sodium channel protein inhibitor and potent neuroprotective agent. It has been shown to preferentially block tetrodotoxin-sensitive sodium channels, which are associated with damaged neurons.
SGTC_1575 cyproterone acetate 48 µM 0.651850273819974 0.222398393053617 no 760 0.25724888305339 1221 9880 An androgen receptor antagonist and liver toxin.
SGTC_785 1270-0111 65.3 µM 0.649725113785549 0.223022079340426 no 761 0.257934899386028 1264 6741994
SGTC_75 0159-0059 199.013 µM 0.648718950844701 0.22331771244702 no 762 0.258260026467348 1376 5377270
SGTC_21 0849-0113 22.993 µM 0.647870852657407 0.223567075728961 no 763 0.258534242085805 1243 1560156
SGTC_1036 k216-0215 33.5 µM 0.645045347411031 0.224398990667292 no 764 0.259448899616188 1265 622330
SGTC_2889 9059656 51.95 µM 0.644942213947597 0.224429389504892 no 765 0.259482317021752 1331 3949838
SGTC_1914 st062367 72.6 µM 0.639732501245663 0.225968002696871 no 766 0.26117326088618 1285 978205
SGTC_1457 k015-0032 57.3 µM 0.639480049020463 0.226042711989762 no 767 0.261255344252669 1295 4302660
SGTC_668 1682-0499 62.6 µM 0.63861128477757 0.226299915866396 no 768 0.261537919127026 1301 682214
SGTC_3070 9117005 49.47 µM 0.634591123295146 0.227492263652626 no 769 0.262847559521361 1336 8779016
SGTC_2267 7931562 200 µM 0.63437170670091 0.22755744253012 no 770 0.262919134840673 1221 934880
SGTC_618 k072-0232 33.2 µM 0.634368810390437 0.227558302965012 no 771 0.262920079705248 1288 5872756 YGL099W LSG1
SGTC_1128 3448-9350 235 µM 0.633622922325307 0.227779952107791 no 772 0.263163468858442 1282 619386
SGTC_1266 0828-0227 32.9 µM 0.63355732507563 0.22779945088946 no 773 0.263184879263332 1281 3913820
SGTC_2974 9094440 9.66 µM 0.632908415512077 0.227992389849654 no 774 0.263396725959519 1379 25236134
SGTC_6 0844-0013 19.835 µM 0.632547734423079 0.228099670155942 no 775 0.263514513584315 1386 1584900
SGTC_517 1365-0151 113 µM 0.630223344594005 0.228791712842857 no 776 0.264274233874374 1331 768657
SGTC_1074 carmofur 3.8 µM 0.629950041702302 0.228873160929028 no 777 0.264363635379514 1319 2577 Carmofur is a derivative of 5-fluorouracil (5-FU). 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2593 nobiletin 86.24 µM 0.629570085102534 0.228986420345933 no 778 0.264487950499164 1248 72344 An anti-infammatory.
SGTC_423 5-fluorouracil 457 µM 0.629507978426572 0.229004936413027 no 779 0.264508273539961 1258 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1104 tacrolimus 29.8 µM 0.626464439168398 0.229913345359449 no 780 0.265505177304927 1328 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12). YLR029C | YDL195W | YDR464W RPL15A | SEC31 | SPP41
SGTC_409 arachidonic acid 100 µM 0.626185304455643 0.229996759905259 no 781 0.265596702523672 1319 231 Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine, phosphatidylcholine, and phosphatidylinositides) of cellular membranes.
SGTC_2660 2',4'-dihydroxychalcone 17.14 µM 0.625397308265787 0.230232330208349 no 782 0.265855164173437 1317 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_2672 12a-hydroxy-5-deoxydehydromunduserone 100 µM 0.624691740028987 0.230443373260389 no 783 0.266086697683138 1264 4620898
SGTC_1819 st053448 58.6 µM 0.623196286572095 0.230891036788354 no 784 0.266577770833696 1290 2857616
SGTC_1051 3253-3903 78 µM 0.6231950274134 0.230891413921607 no 785 0.266578184506002 1271 5509239
SGTC_1505 k297-0037 20.6 µM 0.623193701053155 0.230891811182908 no 786 0.266578620256432 1290 4089396
SGTC_2110 5483698 200 µM 0.623064977558374 0.230930367277807 no 787 0.266620911625834 1310 2848765 YHR062C RPP1
SGTC_1321 1326-2144 215 µM 0.622227209408772 0.231181388829604 no 788 0.266896238427306 1288 3513030
SGTC_1587 estradiol valerate 56.1 µM 0.62180336715875 0.231308443202816 no 789 0.267035585993304 1292 13791 A steroid.
SGTC_3220 9131269 49.47 µM 0.620264014335246 0.231770219478918 no 790 0.26754199129807 1347 17722206
SGTC_461 N-acetylfarnesylcysteine 136 µM 0.619501354556085 0.231999192887034 no 791 0.267793064920758 1323 6438381 Potential activator of peroxisome proliferator-activated receptor γ (PPARγ).
SGTC_3159 9100096 49.47 µM 0.618723489712148 0.232232860999973 no 792 0.268049266394631 1262 25236875
SGTC_122 0236-0016 402.397 µM 0.618185289931688 0.232394611116374 no 793 0.268226602773318 1345 6808838
SGTC_1218 1348-1416 30.7 µM 0.617804600061497 0.232509061163042 no 794 0.268352075402636 1305 6787668
SGTC_2080 5212524 12.4 µM 0.617302069060388 0.232660189332125 no 795 0.268517751180246 1295 260183
SGTC_1198 1612-1005 86.7 µM 0.617227010046682 0.232682766817043 no 796 0.26854250125141 1390 6998509
SGTC_3341 9147222 25.867 µM 0.615548373147587 0.233188012870339 no 797 0.269096316903987 1301 1939759
SGTC_61 0978-8327 98.565 µM 0.614265957327815 0.233574411936117 no 798 0.26951979718478 1338 6150059 YHR072W ERG7
SGTC_1551 6-bromo-3'-methylflavone 63.5 µM 0.613947994708258 0.233670270754243 no 799 0.269624846677935 1360 688751
SGTC_571 k831-0106 44.2 µM 0.611958777372348 0.234270471320283 no 800 0.270282515818486 1353 4783639
SGTC_1482 3346-2049 8.48 µM 0.611606958031202 0.23437671345428 no 801 0.270398916702912 1329 3826804
SGTC_648 0375-0473 33.3 µM 0.611524704449451 0.234401556172592 no 802 0.270426134253828 1333 1713139
SGTC_1676 st018489 23.4 µM 0.611449278265505 0.234424338120054 no 803 0.270451093835371 1345 3696235
SGTC_3077 9117319 49.47 µM 0.61119448512131 0.234501305653148 no 804 0.270535416970069 1329 17154678
SGTC_1842 st055362 61.2 µM 0.610810238861684 0.234617404624132 no 805 0.270662607114613 1340 676032
SGTC_2224 6650123 117.647 µM 0.610781545995002 0.234626075371733 no 806 0.270672105997491 1284 2908370
SGTC_1961 st076550 68.7 µM 0.609612791998622 0.234979413775576 no 807 0.271059167901341 1325 1579337
SGTC_2420 aureobasidin a 50 nM 0.608727884631206 0.235247134950465 no 808 0.2713524104758 1454 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YDR367W KEI1
SGTC_2166 5933061 31.504 µM 0.607964997063084 0.235478075194039 no 809 0.271605344687191 1502 2877375
SGTC_2893 9048488 25.97 µM 0.607128394620032 0.235731474052388 no 810 0.271882853845013 1277 6467338
SGTC_384 k007-0144 5.16 µM 0.606617852589807 0.235886186189559 no 811 0.272052274877217 1350 6824886
SGTC_948 3448-0295 75.3 µM 0.606387938920418 0.235955876366967 no 812 0.272128587813744 1343 678569
SGTC_2141 5621638 7.665 µM 0.60637482222901 0.23595985256904 no 813 0.272132941826314 1378 2856238
SGTC_209 4077-0173 175.592 µM 0.604428247318143 0.236550347714924 no 814 0.272779480171773 1293 15993494
SGTC_194 1486-1323 56.904 µM 0.604073393324044 0.236658080534405 no 815 0.272897423985614 1304 5178754
SGTC_3248 9135562 49.47 µM 0.602790280828155 0.237047855559426 no 816 0.273324106612734 1365 17650701
SGTC_1460 k062-0059 9.15 µM 0.602321575688603 0.2371903234819 no 817 0.273480050852825 1301 1373085
SGTC_1067 clotrimazole 1.36 µM 0.601785200007694 0.237353418284256 no 818 0.273658563978377 1336 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2560 caryophyllene 100 µM 0.600327794211422 0.237796879898748 no 819 0.274143899396794 1361 16667688 A peroxisome proliferator-activated receptor (PPAR) inhibitor.
SGTC_3131 9127911 49.47 µM 0.599001218394794 0.238200927120812 no 820 0.274586036042338 1388 45595681
SGTC_1235 benzylparaben 21.5 µM 0.59867371034618 0.238300737078536 no 821 0.274695245857341 1327 7180
SGTC_1729 st035615 45.989 µM 0.597519336739948 0.238652721660907 no 822 0.275080350404686 1334 17385451
SGTC_1288 0973-0013 65.5 µM 0.595836543462859 0.239166338019944 no 823 0.275642214201077 1389 4315430
SGTC_352 k048-0007 5.11 µM 0.595150538677959 0.239375891227165 no 824 0.275871424467942 1314 6811911
SGTC_2241 6772625 37.8075 µM 0.594873783985941 0.239460459591618 no 825 0.275963921194387 1276 2285411
SGTC_2771 fluoxetine 41.05 µM 0.594676908163529 0.239520629174342 no 826 0.276029730141043 1383 3386 A selective serotonin reuptake inhibitor.
SGTC_2822 7994718 71.43 µM 0.594469804795976 0.239583933427723 no 827 0.276098966127039 1339 1018011
SGTC_518 1021-0119 62.6 µM 0.592801780384108 0.240094122982252 no 828 0.276656908053667 1295 1097762
SGTC_2864 9034755 47.6 µM 0.592596948818242 0.240156814503882 no 829 0.2767254607822 1342 4930451
SGTC_3137 9097352 49.47 µM 0.591645008653434 0.240448285953509 no 830 0.277044163897458 1436 44120435
SGTC_433 pimozide 108 µM 0.589575477935304 0.241082612982483 no 831 0.277737647971713 1297 16362 D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7receptor; Ca2+ channel antagonist; antipsychotic
SGTC_3196 9111891 49.47 µM 0.58877676595682 0.241327667440574 no 832 0.278005516850196 1337 18891510
SGTC_622 1348-1566 26.3 µM 0.587624108559468 0.241681555086174 no 833 0.278392312644052 1418 7340407
SGTC_3074 9116018 49.47 µM 0.586700992038404 0.241965172353113 no 834 0.278702270698937 1400 17027303
SGTC_2529 gangaleoidin 93.61 µM 0.584284149401577 0.24270857464345 no 835 0.279514577256965 1400 4565183
SGTC_543 3844-1095 191 µM 0.584126751698515 0.242757031817916 no 836 0.27956751884561 1404 4230703
SGTC_3067 9117431 49.47 µM 0.58343111628964 0.242971256006662 no 837 0.279801557950633 1354 17150885
SGTC_2409 alverine citrate 63.97 µM 0.583058875441483 0.243085931311996 no 838 0.279926833434896 1481 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_3343 9148379 18.9835 µM 0.582843862974848 0.243152182997406 no 839 0.279999207015708 1438 1955036
SGTC_1332 1480-0653 17.5 µM 0.582519694506779 0.243252087320768 no 840 0.280108339847447 1319 5749438
SGTC_3300 9124615 50.48 µM 0.58228254156043 0.243325188692428 no 841 0.280188191551119 1435 24824903
SGTC_437 s-farnesyl-l-cysteine methyl ester 6.67 µM 0.582027445250979 0.243403834280329 no 842 0.280274097270172 1388 6439225 Stimulates the multidrug resistance transporter ATPase activity (4-5-fold at 10-20 µM) and competes for drug binding.
SGTC_298 1391-0729 10 µM 0.581387239010337 0.243601268821021 no 843 0.280489748001637 1336 3237558
SGTC_2879 9041815 71.43 µM 0.581244065868776 0.243645434115753 no 844 0.280537986248045 1323 4942971
SGTC_623 k072-0108 16.9 µM 0.580201837249079 0.243967065553505 no 845 0.280889257410043 1363 5382803
SGTC_1743 st037606 46.3785 µM 0.578456273900276 0.244506258565346 no 846 0.281478055264602 1408 590142 YLR208W | YDL195W SEC13 | SEC31
SGTC_2103 5378138 10 µM 0.578181886251976 0.244591073450497 no 847 0.281570663388314 1405 244142
SGTC_2800 7887935 81.82 µM 0.577846141617318 0.244694875705171 no 848 0.281683999995858 1399 2961002
SGTC_410 α-linolenic acid 100 µM 0.575702279106041 0.24535825316124 no 849 0.282408217297006 1397 860 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_1738 st035555 74 µM 0.574549894072967 0.245715235809735 no 850 0.282797873740798 1374 5331140
SGTC_2427 5545055 42.75 µM 0.574437756763675 0.245749988278424 no 851 0.282835804561205 1428 5372858
SGTC_815 1582-0027 36.9 µM 0.573207890645476 0.246131309158161 no 852 0.283251971178938 1413 3128206
SGTC_367 0335-0881 7.1 µM 0.570489672991487 0.246975219039274 no 853 0.284172812208675 1424 23828853
SGTC_825 1988-2224 89.6 µM 0.566538129194309 0.248204788975139 no 854 0.285514010331364 1398 1180859
SGTC_2247 cerulenin 830 nM 0.566350358525843 0.248263297193097 no 855 0.285577816718342 1435 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YHR107C CDC12
SGTC_1193 1488-0126 41.5 µM 0.566160894757276 0.248322340423653 no 856 0.285642205315829 1382 1384710
SGTC_301 4119-0100 24.5 µM 0.565570887014385 0.248506254461404 no 857 0.285842761617579 1391 2801 A tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent. YIL048W NEO1
SGTC_2848 9016370 25.97 µM 0.564519183394729 0.248834265761284 no 858 0.286200424227897 1417 7894410
SGTC_1783 st039459 87.517 µM 0.564288761936069 0.248906161683168 no 859 0.286278814168003 1511 729761
SGTC_1580 hydrocortisone 21-hemisuccinate 43.2 µM 0.563773381351117 0.249067010339666 no 860 0.286454184787818 1372 16623 A steroid.
SGTC_178 4092-0806 87.505 µM 0.563679783287221 0.249096227932711 no 861 0.286486039245637 1387 2169044
SGTC_1631 benzylvanillin 81.9 µM 0.563392877017674 0.249185800018681 no 862 0.286583693228364 1427 75506
SGTC_2574 2',4'-dihydroxychalcone 14.64 µM 0.56078846698998 0.249999679274407 no 863 0.287470874887732 1438 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_1865 st057639 52.2 µM 0.558941377342846 0.250577749389406 no 864 0.288100864618763 1393 688818
SGTC_3274 9138298 49.47 µM 0.558153919174266 0.250824409529659 no 865 0.288369642135311 1366 17015756
SGTC_1027 k015-0025 8.67 µM 0.556634015457975 0.251300861137208 no 866 0.288888754130553 1359 3598955
SGTC_2589 lobaric acid 100 µM 0.555756727665716 0.251576086452644 no 867 0.289188585403488 1377 73157 A novel microtubule depolymerizer.
SGTC_669 0108-0021 26.2 µM 0.555174888784434 0.251758710455254 no 868 0.289387521549338 1637 17201
SGTC_1028 k015-0029 4.8 µM 0.554577708088986 0.251946222620208 no 869 0.289591770039839 1403 4588309
SGTC_1886 st057356 49.9 µM 0.554405796207787 0.252000215869772 no 870 0.289650580100578 1329 24207747
SGTC_2642 cholecalciferol 100 µM 0.554228294908194 0.252055971022721 no 871 0.289711308150752 1434 9821465 A vitamin D precursor, similar to steriods.
SGTC_547 1120-0019 610 nM 0.554196501187593 0.252065958474883 no 872 0.289722186283243 1418 3676939
SGTC_1029 k015-0030 64.7 µM 0.551300608179808 0.252976528468351 no 873 0.290713810825264 1448 2208316
SGTC_1102 cgs 12066b 26.1 µM 0.551134248411441 0.25302889031846 no 874 0.290770824654802 1400 6438352 A 5-HT1B full agonist.
SGTC_3200 9114385 49.47 µM 0.549598801628964 0.253512442303414 no 875 0.291297290481841 1362 17018030 YLR208W SEC13
SGTC_1662 st014054 52 µM 0.549477196809023 0.253550759551575 no 876 0.291339004701367 1397 2838777
SGTC_3031 9088762 49.47 µM 0.549312295651435 0.253602724182409 no 877 0.291395575358292 1353 205253
SGTC_887 0885-0007 9.62 µM 0.546925394100935 0.254355524847183 no 878 0.292214994354677 1473 5719458
SGTC_2290 7904846 200 µM 0.543783308609139 0.255348284551033 no 879 0.293295298094665 1404 2962154
SGTC_3019 9081971 49.47 µM 0.542928279367372 0.255618785999707 no 880 0.293589592120408 1509 16451803
SGTC_1757 st041620 31.8375 µM 0.54228008490574 0.255823951822022 no 881 0.293812786388961 1390 5289815
SGTC_801 0866-0028 10.1 µM 0.538271760674963 0.257094568942379 no 882 0.295194722110118 1433 6849771
SGTC_2874 9043904 71.43 µM 0.537912704665618 0.257208547710114 no 883 0.295318658472684 1410 4463428
SGTC_3115 9123671 49.47 µM 0.536626887713801 0.257616932927709 no 884 0.295762683778697 1488 3286988
SGTC_1768 st044301 37.178 µM 0.53623250588396 0.257742259029179 no 885 0.295898935300634 1395 3931349
SGTC_1707 st032323 6.317 µM 0.53458585657461 0.258265870646916 no 886 0.296468132912784 1400 3132057 YMR211W DML1
SGTC_421 streptovitacin 30 mM 0.533945040536313 0.258469790176179 no 887 0.296689779484464 1453 91467 include heat shock
SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.66 µM 0.530319690344866 0.259625012354812 no 888 0.297945148461824 1536 16725076
SGTC_2754 granisetron 64.02 µM 0.530216234759003 0.259658017675506 no 889 0.297981008079585 1517 5284566 A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
SGTC_2615 purpurogallin-4-carboxylic acid 100 µM 0.529201469355003 0.259981871931416 no 890 0.298332848751898 1395 269315 Purpurogallin is a red, crystalline compound, and the aglycon of several glycosides from nutgalls and oak barks. It can inhibit hydroxyestradiol methylation by catechol-O-methyltransferase.
SGTC_2818 7996756 12.99 µM 0.528801941747895 0.260109435096822 no 891 0.298471425308302 1413 2241621
SGTC_1953 st076800 12.1 µM 0.527588622732532 0.260497027329518 no 892 0.298892445656635 1393 297591
SGTC_2758 dehydroepiandrosterone 69.35 µM 0.527085980528516 0.260657682413075 no 893 0.299066940944444 1463 5881 A major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. [PubChem]
SGTC_2921 7974240 10.71 µM 0.526871544339463 0.260726236271391 no 894 0.299141397839237 1494 2979074 YDR527W RBA50
SGTC_208 k072-0098 12.366 µM 0.525902946223607 0.261036006365548 no 895 0.299477820893244 1431 5948901
SGTC_162 k030-0015 37.8 µM 0.525280849811073 0.261235060515129 no 896 0.299693983972267 1544 1809920 YMR134W ERG29
SGTC_693 4161-2696 114 µM 0.525275174610746 0.26123687678579 no 897 0.299695956288953 1531 805759
SGTC_473 2-arachidonoylglycerol 10 µM 0.523806254506992 0.261707202763711 no 898 0.30020665137291 1422 5282280 An endocannabinoid.
SGTC_2717 st081029 62.2815 µM 0.523348828396091 0.261853752343143 no 899 0.300365763651069 1430 5292846
SGTC_2908 7930301 100 µM 0.52315062045536 0.261917267011627 no 900 0.300434720643618 1362 2223178
SGTC_1262 0737-0114 49.6 µM 0.522867711800441 0.262007937251449 no 901 0.300533157593632 1469 765919
SGTC_598 3937-0236 20.2 µM 0.521445577629296 0.262463964897912 no 902 0.301028204037634 1489 1379313
SGTC_2393 9031399 185.94 µM 0.521241818188396 0.262529336539831 no 903 0.301099163015009 1513 1526623 YDL150W RPC53
SGTC_3182 9108849 49.47 µM 0.519970940330362 0.262937257177942 no 904 0.301541914700773 1451 17133045
SGTC_2821 7996764 71.43 µM 0.518916679696095 0.263275894723155 no 905 0.301909422843952 1508 2987135
SGTC_448 monastrol 171 µM 0.517971428863971 0.263579706657723 no 906 0.302239101906649 1476 2987927 Monastrol is a cell-permeable small molecule inhibitor discovered by Thomas U. Mayer in the lab of Tim Mitchison. Monastrol was shown to inhibit the kinesin Eg5, a motor protein important for spindle bipolarity
SGTC_3044 9093193 49.47 µM 0.517162845202461 0.263839734450132 no 907 0.302521243127088 1402 25236277
SGTC_3090 9117696 49.47 µM 0.516183602951984 0.264154818378589 no 908 0.302863090680028 1543 7923821
SGTC_1933 st074711 15.9 µM 0.515054172585636 0.264518465155041 no 909 0.303257582613692 1417 17250958
SGTC_660 4031-1742 102 µM 0.514740705033 0.264619438576257 no 910 0.303367112520324 1443 6738706
SGTC_2202 7226349 200 µM 0.513563093447286 0.264998943113224 no 911 0.303778744181369 1434 844334
SGTC_1463 k081-0032 34.1 µM 0.512975753452165 0.265188326308539 no 912 0.303984140744724 1354 977755
SGTC_2055 5235184 200 µM 0.511977037300545 0.265510512249305 no 913 0.304333540261261 1478 2836034
SGTC_3288 9119690 36.221 µM 0.511224993569124 0.265753252637291 no 914 0.304596759719355 1410 17595618 YKL019W RAM2
SGTC_1089 terbinafine 2.25 µM 0.510792451364675 0.265892917087089 no 915 0.304748197735665 1516 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_331 k048-0133 24.5 µM 0.510143068521135 0.266102667473368 no 916 0.304975616984957 1443 6813582
SGTC_2276 7947513 42.08 µM 0.507118426235937 0.267080728422289 no 917 0.306035863452131 1319 2105100
SGTC_2983 9022671 12.99 µM 0.506225923191543 0.26736967835201 no 918 0.306349029332862 1594 6405161
SGTC_2155 5570423 76 µM 0.505912748466744 0.26747110675882 no 919 0.306458951180626 1472 797402
SGTC_3296 9122258 64.045 µM 0.505814163432917 0.267503039669008 no 920 0.306493557351385 1501 4730474
SGTC_3147 9097027 49.47 µM 0.505113024248445 0.267730202752803 no 921 0.306739727054421 1584 25236841
SGTC_1096 rimcazole 32.2 µM 0.503756718886814 0.268169909781375 no 922 0.307216172761684 1451 18528119 A dopamine reuptake inhibitor.
SGTC_2671 danthron 100 µM 0.503383127769278 0.268291089852012 no 923 0.307347465839474 1455 2950 Danthron, derived from the anthraquinones, is an established mutagen and genotoxin.
SGTC_1678 st019265 80.2 µM 0.501665913534887 0.268848448978168 no 924 0.307951272805176 1614 5367020
SGTC_2909 7941780 10.49 µM 0.501612080677885 0.268865930995033 no 925 0.307970209936797 1516 1243215
SGTC_631 k072-0230 41.5 µM 0.500324660000553 0.269284185989014 no 926 0.308423246475594 1523 5773147
SGTC_2438 5259590 200 µM 0.498734942530171 0.269801100484565 no 927 0.308983062367061 1561 1201127
SGTC_1873 rapamycin 2 nM 0.498690914027364 0.269815423914608 no 928 0.308998573242042 1478 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YMR211W | YHR007C | YHR186C DML1 | ERG11 | KOG1
SGTC_1728 st035614 33.7865 µM 0.498177502963033 0.269982475806267 no 929 0.309179468820057 1526 15945546
SGTC_561 1550-0330 72.9 µM 0.497154290980487 0.270315559228221 no 930 0.30954012594786 1452 6812934
SGTC_1214 0358-0031 63.7 µM 0.495996527815649 0.270692690301772 no 931 0.309948430346961 1680 4301366
SGTC_2256 7954252 200 µM 0.494535538924924 0.271168969123675 no 932 0.310464006998307 1457 2972920
SGTC_264 promethazine 12.5 mM 0.493963118187663 0.271355690749825 no 933 0.310666113447082 1486 6014 Promethazine is a Na+ channel blocker. YMR168C CEP3
SGTC_1589 2',5'-dimethoxyflavone 47.2 µM 0.492562130410449 0.271812958153574 no 934 0.311161005774537 1463 688667
SGTC_2124 5246320 200 µM 0.49052201710285 0.272479514268977 no 935 0.311882276936723 1522 579342
SGTC_229 benomyl 22.8748 µM 0.487476001048871 0.273476232290998 no 936 0.312960522974842 1468 28780 Benomyl is a fungal microtubule inhibitor often used in molecular biology to study the cell cycle in yeast. YIL142W | YJL014W | YDR212W | YDR187C CCT2 | CCT3 | TCP1 | YDR187C
SGTC_578 3460-0051 92 µM 0.487114289580405 0.273594711372257 no 937 0.313088670229397 1531 2876744
SGTC_790 1575-0012 79.1 µM 0.486803037680059 0.273696682681523 no 938 0.31319895872799 1542 378741 YLR208W SEC13
SGTC_2357 9067248 200 µM 0.486219295728385 0.273887976952729 no 939 0.313405845969925 1509 9150235
SGTC_992 3909-8734 162 µM 0.486183458313168 0.273899723151782 no 940 0.313418549222167 1489 4288319
SGTC_1076 itraconazole 331 nM 0.485313536096462 0.274184928331256 no 941 0.313726977534991 1497 3793 Itraconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR217W RFC1
SGTC_1290 0986-0249 10.2 µM 0.484642485577759 0.274405033325892 no 942 0.313964985476254 1478 53329
SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 61.8 µM 0.484376989038351 0.27449214043048 no 943 0.314059173065896 1508 17037758
SGTC_1849 st056239 19.2 µM 0.483534929083837 0.274768503206234 no 944 0.314357982484922 1409 5393181
SGTC_1106 tegaserod maleate 11.7 µM 0.482743327262714 0.275028430734144 no 945 0.31463899754219 1535 6918369 Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation.
SGTC_2984 9022109 38.96 µM 0.482237216648853 0.275194678848973 no 946 0.314818720811866 1548 6459207
SGTC_3029 9088683 49.47 µM 0.47945057751077 0.27611092423249 no 947 0.315809059832956 1503 25236615
SGTC_2841 9004761 38.96 µM 0.479260149103595 0.27617359161015 no 948 0.315876784264344 1410 2991039
SGTC_993 3909-8757 62.7 µM 0.478626768974098 0.276382078536755 no 949 0.316102085604981 1524 4288324 YLR208W SEC13
SGTC_678 1218-2179 85.9 µM 0.474228291404093 0.277832031688352 no 950 0.31766856037 1544 6820081 YOR116C RPO31
SGTC_2871 9038510 12.99 µM 0.47238912162812 0.278439411077462 no 951 0.318324533830562 1650 4945164
SGTC_2995 9067767 71.4286 µM 0.472201412556426 0.278501437709836 no 952 0.31839151579055 1543 11673567
SGTC_2426 5582046 32.21 µM 0.472115571452063 0.278529805308573 no 953 0.318422149242395 1548 2251934
SGTC_1384 3089-0840 101 µM 0.47203612583281 0.278556060668579 no 954 0.318450501493078 1615 1069836
SGTC_1548 st061468 90.8 µM 0.471471934095269 0.278742550644454 no 955 0.318651878675289 1540 390799
SGTC_2176 5809774 33.9695 µM 0.470763108887615 0.278976934400064 no 956 0.318904955868446 1574 2870539
SGTC_3188 9110789 49.47 µM 0.470653868717376 0.279013064835209 no 957 0.318943966221768 1581 849217
SGTC_2168 5727979 200 µM 0.46990485551862 0.279260857079575 no 958 0.319211497560757 1449 695210
SGTC_499 genistein 192 µM 0.469159269348475 0.279507621740751 no 959 0.319477898372165 1595 6610345 A kinase inhibitor, peroxisome proliferator-activated receptor activator and oxygen scavenger.
SGTC_2722 naftopidil 47.16 µM 0.466879147006839 0.280262924078751 no 960 0.320293172726053 1566 4418 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_1236 0330-0013 258 µM 0.464997532904918 0.28088696213145 no 961 0.320966611668941 1530 4617066
SGTC_1519 esterone 74 µM 0.464067580379379 0.281195629070619 no 962 0.321299664033146 1469 698 A steroid.
SGTC_3154 9100113 49.47 µM 0.463985482281061 0.281222886681806 no 963 0.3213290734819 1487 25237525
SGTC_3277 9138724 49.47 µM 0.463512738468025 0.281379868451409 no 964 0.321498443107621 1526 15943418
SGTC_1549 4'-methoxyflavonol 74.6 µM 0.46326362149617 0.281462608540264 no 965 0.321587709021786 1532 97141
SGTC_1229 0139-0193 12.2 µM 0.460690233481895 0.282318003127058 no 966 0.322510431496817 1629 3090752
SGTC_2092 5303694 80.6725 µM 0.459991193751358 0.282550579886007 no 967 0.322761270733887 1511 1963699
SGTC_929 2805-0021 398 µM 0.458956870329577 0.282894877409067 no 968 0.323132569126373 1588 3098024
SGTC_755 1995-0008 37.3 µM 0.457999321104159 0.283213798419733 no 969 0.323476464506847 1541 689533
SGTC_1182 1222-0449 220 µM 0.456662930909757 0.283659184184872 no 970 0.3239566694135 1563 658318
SGTC_2535 4',4'-dimethoxydalbergione 51.19 µM 0.455647147881907 0.283997943786064 no 971 0.324321866719835 1591 364106
SGTC_1852 st056254 31.4 µM 0.455204650794172 0.284145575308623 no 972 0.324481007459921 1596 442583
SGTC_2451 5856223 45.7 µM 0.45435902089361 0.284427807183916 no 973 0.324785221027036 1494 2179896
SGTC_197 4544-0043 41.561 µM 0.454236957171649 0.284468557428385 no 974 0.324829142852267 1535 896523
SGTC_1677 st019204 53.9 µM 0.453903908365482 0.284579757967259 no 975 0.324948995197466 1490 3945625
SGTC_2744 captopril 92.04 µM 0.453322419615965 0.28477395902302 no 976 0.325158295615921 1645 44093 angiotensin-converting enzyme (ACE) inhibitor
SGTC_1568 digitonin 820 nM 0.453003102843513 0.284880628830017 no 977 0.325273253616178 1714 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes. YMR211W DML1
SGTC_2087 5276107 200 µM 0.452458152295005 0.285062717051358 no 978 0.325469480978788 1519 144405
SGTC_931 2812-0076 566 µM 0.452085221608626 0.285187359017794 no 979 0.325603794825056 1542 3450959
SGTC_2017 5132927 60.65 µM 0.451882408249159 0.285255154783289 no 980 0.325676849119601 1502 8367 Originally believed to exert its effects predominantly via monoamine oxidase inhibition, etryptamine was developed during the 1960s as an antidepressant by Upjohn as Monase but was withdrawn from potential commercial use due to an unacceptable incidence of agranulocytosis
SGTC_87 0100-0052 35.5 µM 0.451779173686286 0.285289666633477 no 981 0.3257140372503 1610 200187 YGR083C | YDR527W GCD2 | RBA50
SGTC_1643 st009866 20.2 µM 0.4511215367885 0.285509564745798 no 982 0.32595097813841 1607 3156273 YOR207C RET1
SGTC_1052 3253-3998 198 µM 0.446583038089469 0.287029326212351 no 983 0.327588072382281 1522 5450317
SGTC_2944 9067346 25.62 µM 0.446432917086513 0.287079661117479 no 984 0.327642279836694 1589 6473075
SGTC_809 3998-0021 90 µM 0.44605091943572 0.287207762078895 no 985 0.327780232415733 1596 715485
SGTC_1723 st034307 2.5525 µM 0.445368606072199 0.287436639680023 no 986 0.328026697881304 1552 867466
SGTC_1840 st055363 71 µM 0.444848933722307 0.287611018256825 no 987 0.328214464361826 1498 676033
SGTC_3336 9143619 71.43 µM 0.443341657918941 0.288117074608042 no 988 0.328759314222463 1594 45595730
SGTC_1094 duloxetine 25.4 µM 0.442469317964466 0.288410147912436 no 989 0.329074814010348 1569 60834 A selective serotonin reuptake inhibitor.
SGTC_83 0170-0301 39.027 µM 0.441167634847098 0.288847725427907 no 990 0.329545821049318 1576 3089716
SGTC_2561 acetosyringone 100 µM 0.441049064040521 0.288887600052699 no 991 0.329588738713099 1538 17198 A non-steroidal anti-inflammatory agent and anti-asthmatic agent.
SGTC_787 4152-0075 138 µM 0.441017037283856 0.288898370896124 no 992 0.329600331442086 1595 9566539
SGTC_404 fumagillin 50 µM 0.439975854329491 0.289248631589241 no 993 0.329977297696592 1585 12015870 A methionine aminopeptidase binder.
SGTC_654 1124-0271 80.9 µM 0.438330747817383 0.289802462570934 no 994 0.330573269868747 1527 5403748
SGTC_1491 4138-0063 26.5 µM 0.43645379393915 0.290434952730704 no 995 0.331253758294156 1615 23883227
SGTC_1539 benzyladenosine 56 µM 0.43590421289635 0.290620271095694 no 996 0.331453114188795 1536 92208 A nucleotide analog.
SGTC_890 0929-0006 47.2 µM 0.435092710515043 0.290894010264631 no 997 0.331747567163196 1518 1378169
SGTC_1957 st077035 62.4 µM 0.434967135736802 0.290936380406269 no 998 0.331793141162944 1599 705593
SGTC_617 3770-0098 35 µM 0.434319253103276 0.29115502806737 no 999 0.332028312339116 1580 5962639
SGTC_1667 st014849 34.6 µM 0.434318419817211 0.291155309334448 no 1000 0.332028614851447 1589 5348460
SGTC_3315 9136395 68.55 µM 0.432191544708607 0.291873627079976 no 1001 0.332801102075492 1674 16876844
SGTC_843 0310-0051 143 µM 0.432084776337979 0.291909708123172 no 1002 0.332839899408176 1607 2065037
SGTC_2636 apigenin dimethyl ether 100 µM 0.429878140717218 0.292655877874511 no 1003 0.33364214363507 1601 5281601 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_705 1124-0212 310 µM 0.42896916216796 0.292963504732572 no 1004 0.333972833376334 1682 9554485
SGTC_555 4296-0685 37 µM 0.42878204255627 0.293026850498246 no 1005 0.334040924194239 1621 2908540 YHR072W ERG7
SGTC_1916 st067606 49.2 µM 0.428113883214412 0.293253094901521 no 1006 0.334284104776436 1682 19590279
SGTC_1479 0549-0158 134 µM 0.427803066124684 0.29335836778426 no 1007 0.334397252226815 1586 5440202
SGTC_2857 9024691 58.44 µM 0.426178746008608 0.293908805154875 no 1008 0.334988801733688 1578 16478292
SGTC_2343 7990716 14.84 µM 0.424557427793715 0.294458701112151 no 1009 0.335579666507818 1627 6456862
SGTC_1086 cerivastatin 2.18 µM 0.423077222409507 0.294961150702511 no 1010 0.336119460170081 1614 23663992 Cerevastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. Cerivastatin was withdrawn from the market due to reports of fatal rhabdomyolysis. YPR034W ARP7
SGTC_427 1354-0053 47.3 µM 0.4217541919087 0.295410581987601 no 1011 0.336602222330158 1678 6813657
SGTC_322 k048-0136 19.3 µM 0.421454988966451 0.295512264395523 no 1012 0.336711436228364 1601 6823282
SGTC_1517 deoxycholic acid methyl ester 49.2 µM 0.421275519255468 0.295573263871376 no 1013 0.33677695217543 1559 229346 A bile salt which induces apoptosis.
SGTC_100 0086-0128 49.5915 µM 0.421060692780072 0.29564628827364 no 1014 0.336855381726992 1497 93297
SGTC_2776 terbinafine 19.92 µM 0.419924715699974 0.296032570493708 no 1015 0.337270225827606 1575 5282481 Terbinafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane terbinafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_830 4076-0286 57.8 µM 0.419923760033989 0.296032895559724 no 1016 0.337270574907824 1625 6866659
SGTC_1388 3346-4487 254 µM 0.418286852262369 0.296589923592956 no 1017 0.337868700637321 1645 3345614
SGTC_2476 5806916 10.51 µM 0.418249649062566 0.296602589154827 no 1018 0.337882299444423 1644 2870194
SGTC_26 0302-0163 425.158 µM 0.418108767771602 0.296650553422711 no 1019 0.337933797403054 1622 3100915
SGTC_999 SEC7.066 22.7 µM 0.417229294424897 0.296950058091305 no 1020 0.338255349955047 1649 740511 YDR170C SEC7
SGTC_82 0054-0107 293.755 µM 0.416456904978014 0.297213209378981 no 1021 0.338537847892377 1715 3104697
SGTC_1271 0832-2808 169 µM 0.415838062242018 0.297424124538153 no 1022 0.338764252402814 1716 3663794
SGTC_2695 st077686 51.995 µM 0.415162446796081 0.297654467102361 no 1023 0.339011493822652 1560 2876092
SGTC_230 MPP+ 141.667 µM 0.412725057450244 0.298486140050507 no 1024 0.339904032056673 1552 39484 MPP+ (1-methyl-4-phenylpyridinium) is a toxic positively charged molecule and acts by interfering with oxidative phosphorylation in mitochondria, causing depletion of ATP and cell death.
SGTC_2863 9028737 58.44 µM 0.412419514745753 0.298590470227891 no 1025 0.340015981018823 1715 6460917
SGTC_3172 9105863 49.47 µM 0.412103289764908 0.298698465421639 no 1026 0.340131858757273 1651 2348785
SGTC_1813 st051246 8.6015 µM 0.411923395430803 0.298759909741909 no 1027 0.340197786122834 1704 5291959
SGTC_1017 4239-0030 168 µM 0.41179511431271 0.298803728672228 no 1028 0.340244801350124 1526 1149593
SGTC_121 0557-0495 61.343 µM 0.410239813549783 0.299335228582821 no 1029 0.340815018884791 1629 3104427
SGTC_2069 5228469 200 µM 0.410143370484973 0.29936820061928 no 1030 0.340850389653192 1578 2835210
SGTC_2388 9080168 200 µM 0.408326009723316 0.299989829151777 no 1031 0.341517173171575 1540 15943073
SGTC_738 1315-0003 72.4 µM 0.408041818924243 0.300087089443654 no 1032 0.341621486615495 1693 6251474
SGTC_1358 1509-0022 2.48 µM 0.406665982217938 0.30055815168428 no 1033 0.342126664260428 1624 3258434
SGTC_1492 4158-0558 28.5 µM 0.399096229203306 0.303155851884835 no 1034 0.344911150310436 1734 3967268
SGTC_2035 5154463 94.595 µM 0.398693394573362 0.303294372999944 no 1035 0.34505956778187 1697 2769623
SGTC_2680 butyl paraben 22.24 µM 0.39856703597306 0.303337829249207 no 1036 0.345106127341291 1642 7184 An antifungal and steroid mimetic.
SGTC_2516 gossypol 71.55 µM 0.398544692328865 0.30334551378792 no 1037 0.345114360584288 1759 3503 Gossypol is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1693 xanthone 101.9 µM 0.392396317701262 0.305463390071277 no 1038 0.347382703193134 1672 7020 An insecticide.
SGTC_1682 st012968 530 nM 0.391703432576306 0.305702472591338 no 1039 0.347638676742963 1574 24207270
SGTC_955 1216-0110 33 µM 0.39155872310083 0.305752415581334 no 1040 0.347692145747448 1569 3619719
SGTC_1826 st055655 41.6 µM 0.391482027340213 0.305778886740837 no 1041 0.347720485451715 1630 676168
SGTC_522 1273-0010 11.6 µM 0.390675531260263 0.306057306265389 no 1042 0.348018543772597 1694 5705015
SGTC_1487 3970-0795 2.82 µM 0.389157697072625 0.306581598639206 no 1043 0.348579747294335 1678 3765103
SGTC_1014 4130-3005 69.3 µM 0.388899240780841 0.306670914460981 no 1044 0.34867534190888 1614 743608
SGTC_773 4358-1457 44.6 µM 0.388874238466209 0.306679555224568 no 1045 0.34868458996541 1784 1186886
SGTC_2391 6285546 200 µM 0.388352085493647 0.306860035079223 no 1046 0.34887774863206 1608 846083
SGTC_2325 6158266 200 µM 0.38819408582366 0.30691465619291 no 1047 0.34893620475372 1621 3623240
SGTC_2309 7664088 163.95 µM 0.388008399647658 0.306978854120611 no 1048 0.349004908807277 1785 704922
SGTC_1889 st059080 5.18 µM 0.387153224271546 0.307274593252994 no 1049 0.349321388337535 1779 176925 Isolated from Daphnopsis sellowiana.
SGTC_2604 4'-hydroxychalcone 11.32 µM 0.386509345994862 0.307497343782625 no 1050 0.349559741137152 1626 5282362
SGTC_2733 amorolfine 100 µM 0.385810660310016 0.307739135339772 no 1051 0.349818449820139 1743 54260 Amorolfine is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_3290 9121031 71.43 µM 0.384777556127536 0.308096810906151 no 1052 0.350201114452602 1609 17014854
SGTC_1937 st074714 47.2 µM 0.384691527341522 0.308126603540865 no 1053 0.350232986618741 1565 17250970
SGTC_1959 st077091 55.8 µM 0.383508488275886 0.308536430048671 no 1054 0.350671388880627 1635 821356 YKL052C ASK1
SGTC_3222 9128301 49.47 µM 0.382414609283992 0.308915582244411 no 1055 0.351076927868462 1630 4911358
SGTC_2875 9039966 71.43 µM 0.380403355387855 0.309613239503672 no 1056 0.351823012135515 1761 6463691
SGTC_1624 st003710 6.25 µM 0.380024578105604 0.309744705442392 no 1057 0.351963585359195 1758 24207033
SGTC_667 1498-1044 59 µM 0.3795376301044 0.309913751008839 no 1058 0.352144333027076 1686 6739982
SGTC_2922 7999257 32.47 µM 0.378958971941778 0.310114686318153 no 1059 0.352359165542914 1621 2988377
SGTC_3206 9114350 49.47 µM 0.378838079045817 0.310156672759409 no 1060 0.35240405416766 1632 17087243
SGTC_1082 camptothecin 424.86 nM 0.378244791524747 0.310362759046353 no 1061 0.352624376976778 1463 2538 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_1336 1486-0901 104 µM 0.376679147327127 0.310906892136601 no 1062 0.353206030678363 1696 5006114
SGTC_1292 0kpi-0043 232 µM 0.375365033449367 0.311363926357607 no 1063 0.353694503072813 1647 3333905
SGTC_1065 prochlorperazine maleate 2.48 µM 0.373413463789545 0.312043197286914 no 1064 0.35442037018508 1676 6436057 A phenothiazine class of antipsychotic, more potent than chlorpromazine.
SGTC_302 1094-0063 18.9 µM 0.372515100425886 0.312356100270801 no 1065 0.354754685593191 1659 5440289
SGTC_1962 st076595 64.5 µM 0.36857791879591 0.313729028126802 no 1066 0.35622117838868 1675 279619
SGTC_3266 9136860 49.47 µM 0.367917487423774 0.313959579564693 no 1067 0.356467380177965 1654 4871271 YPR165W RHO1
SGTC_1124 fisetin 1.16336 µM 0.367531685255092 0.314094293709052 no 1068 0.356611230811978 1644 5281614 Fisetin is a natural flavonol thought to be a sirtuin-activating compound; demonstrated to alleviate aging effects in the model organisms yeast S. cerevisiae, the nematode C. elegans and the fruit fly D. melanogaster.
SGTC_850 0388-0143 75.9 µM 0.365765563584621 0.314711302976002 no 1069 0.357270009087728 1650 67273
SGTC_2279 7948423 32.93 µM 0.365167845588507 0.314920238058247 no 1070 0.357493059444733 1844 1247112
SGTC_3187 9109394 49.47 µM 0.364790194736237 0.315052278202085 no 1071 0.357634012475055 1609 17098090
SGTC_1432 4049-0298 68.4 µM 0.361727511269665 0.31612397300585 no 1072 0.358777833131607 1804 741646
SGTC_2499 avocadenofuran 51.48 µM 0.36151704536009 0.316197676176894 no 1073 0.35885648251734 1610 6857792 A insecticide and lysyl oxidase inhibitor.
SGTC_771 0250-0039 27.3 µM 0.36078811963497 0.316452995509104 no 1074 0.359128922323387 1689 3005115
SGTC_2684 capsaicin 100 µM 0.360576450917156 0.316527152680126 no 1075 0.359208048045792 1708 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_2228 7354201 200 µM 0.359506656543783 0.316902063066457 no 1076 0.359608049506814 1772 753451
SGTC_2140 5586273 200 µM 0.358374095430995 0.317299175086096 no 1077 0.360031687432733 1678 854421
SGTC_1993 st073995 70.8 µM 0.357684704250612 0.317541000662252 no 1078 0.360289640532559 1702 3098394
SGTC_164 4100-3994 89.624 µM 0.356412792941255 0.317987367785892 no 1079 0.360765725108819 1834 4615967
SGTC_1062 mesoridazine 14.2 µM 0.354802113224089 0.318553002573191 no 1080 0.361368922562591 1700 4078 A neuroleptic.
SGTC_710 3448-4187 58 µM 0.352543565098998 0.319346866779528 no 1081 0.362215326324383 1689 3946412
SGTC_564 3555-0129 330 µM 0.350699999375735 0.319995482182758 no 1082 0.362906713011411 1767 563260
SGTC_136 0097-0015 404.482 µM 0.349423431195563 0.320444935574167 no 1083 0.363385722521864 1788 4861337
SGTC_312 4092-0653 6.84 µM 0.349403837897312 0.320451836025921 no 1084 0.363393076225663 1784 1148278
SGTC_2417 cerulenin 830 nM 0.348996371902606 0.320595353210848 no 1085 0.363546016668746 1691 5282054 Cerulenin, an antibiotic and antifungal, is an inhibitor of fatty acid biosynthesis. YKL182W FAS1
SGTC_2956 9076196 2.52 µM 0.348630371837837 0.320724288186219 no 1086 0.363683411613656 1722 16423868
SGTC_206 4546-0025 72.014 µM 0.347618523706819 0.321080855876236 no 1087 0.364063346499182 1719 6620745 YIL048W NEO1
SGTC_1885 st057546 99.9 µM 0.345978533672311 0.321659126482683 no 1088 0.364679423651363 1796 702008
SGTC_2136 5328288 199.296 µM 0.345612516381383 0.321788245500437 no 1089 0.364816969150416 1670 262395
SGTC_1325 1431-0015 227 µM 0.34453437067843 0.322168705336109 no 1090 0.365222226171665 1628 1103340
SGTC_416 estradiol valerate 100 µM 0.342144914144983 0.323012569074321 no 1091 0.366120919120904 1737 13791 A steroid.
SGTC_3180 9109287 49.47 µM 0.340267870429789 0.323676108197604 no 1092 0.366827405386771 1729 18891271
SGTC_3097 9117246 49.47 µM 0.339644554850808 0.323896575806795 no 1093 0.367062110356414 1692 16423892
SGTC_1802 st050112 57.9 µM 0.339274199714031 0.324027600218713 no 1094 0.367201588442753 1729 4662563
SGTC_620 0109-0052 432 µM 0.339211760910326 0.324049691995774 no 1095 0.367225105018023 1807 493037
SGTC_2817 7995342 71.43 µM 0.338525729293292 0.324292460973113 no 1096 0.367483520620676 1626 18879975
SGTC_2400 5203494 178.7 µM 0.338361286590896 0.324350664128473 no 1097 0.367545472110561 1663 6777674
SGTC_742 0kpi-0133 140 µM 0.337583150374898 0.324626137288342 no 1098 0.367838670778816 1850 2728852
SGTC_1241 0364-0022 50.8 µM 0.336619139296836 0.324967546321367 no 1099 0.36820201317427 1763 4563895
SGTC_62 0180-0423 3.232 µM 0.335723416252393 0.325284902628496 no 1100 0.368539723038212 1782 30102 YGL099W LSG1
SGTC_1184 1269-1718 139 µM 0.333458651126416 0.326087878028933 no 1101 0.369394048336405 1837 5403821
SGTC_1341 1486-1360 280 µM 0.333181042326213 0.326186360187313 no 1102 0.369498813712129 1702 3976547
SGTC_699 0375-0592 111 µM 0.332426232095385 0.326454191575786 no 1103 0.369783716686919 1849 762578
SGTC_2484 5809818 12.04 µM 0.332190208317261 0.326537958915702 no 1104 0.369872818496412 1729 2870548
SGTC_1669 st015249 58.4 µM 0.329511577802814 0.327489245367265 no 1105 0.370884522160245 1872 722793
SGTC_2562 3',7'-dimethoxyflavone 64.92 µM 0.329297196779106 0.327565428988607 no 1106 0.370965531362504 1894 688664
SGTC_313 3474-0040 5.03 µM 0.328167751158887 0.327966913502247 no 1107 0.371392414839936 1700 1043375 YIL048W NEO1
SGTC_989 1501-0895 10.3 µM 0.325557189262009 0.328895651536227 no 1108 0.372379703480766 1878 2830112
SGTC_672 1441-0018 53.7 µM 0.325331637153598 0.328975944055236 no 1109 0.372465044536067 1694 251141
SGTC_900 1112-0045 141 µM 0.322969757166063 0.329817204536462 no 1110 0.373359072994471 1770 56211 YIL048W NEO1
SGTC_677 0929-0063 136 µM 0.322261819158571 0.330069527739504 no 1111 0.373627177675345 1724 1539583
SGTC_604 1000-0114 314 µM 0.322131390284765 0.33011602362536 no 1112 0.373676579343403 1855 1572745
SGTC_3133 9127736 49.47 µM 0.321708680193609 0.3302667312955 no 1113 0.373836700664692 1925 27243420
SGTC_2187 6125751 200 µM 0.319707245646175 0.330980670804895 no 1114 0.374595133309598 1768 874498
SGTC_2433 5607874 27.82 µM 0.319686718118965 0.330987996449849 no 1115 0.374602914623164 1701 2252428
SGTC_2897 9048598 12.99 µM 0.317982690548451 0.331596337037581 no 1116 0.375249033470393 1737 6467404
SGTC_2038 4100038 30.985 µM 0.31588394720998 0.332346202529747 no 1117 0.376045298412042 1773 3596803
SGTC_2809 7964133 12.99 µM 0.315736390227776 0.332398948852665 no 1118 0.376101301557377 1778 1253665
SGTC_1920 st075728 45.7 µM 0.314924437978941 0.332689251989699 no 1119 0.376409513089118 1899 3400306
SGTC_2372 9071633 200 µM 0.314568531949691 0.332816533281314 no 1120 0.37654463744652 1856 21321366
SGTC_1180 1193-0155 285 µM 0.313930443414832 0.33304477864171 no 1121 0.376786933932352 1723 2921347
SGTC_2098 5376439 882.5 nM 0.313850133516935 0.333073510014273 no 1122 0.376817432837458 1866 2844116
SGTC_19 0279-0214 38.434 µM 0.312282069738102 0.333634690882715 no 1123 0.377413082725181 1788 3566274 YBR002C RER2
SGTC_167 3672-0051 66.205 µM 0.311565668449461 0.333891201603462 no 1124 0.377685314459066 1708 3237971
SGTC_2041 5107442 45.335 µM 0.31098233215671 0.33410012515342 no 1125 0.377907026528135 1857 793005
SGTC_1789 tunicamycin 25 nM 0.310949009697537 0.334112061239912 no 1126 0.37791969280709 1874 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1903 st060211 78.3 µM 0.308153634118206 0.335113959602132 no 1127 0.378982715699689 1880 688960
SGTC_2073 5212005 126 µM 0.307607726615654 0.33530975711199 no 1128 0.37919042006562 1905 691789
SGTC_71 0417-1750 47.813 µM 0.307415257836053 0.335378799456076 no 1129 0.379263658018104 1924 6811472
SGTC_132 0417-1715 25.805 µM 0.306950625477674 0.335545495148631 no 1130 0.379440477130219 1914 6769098
SGTC_1687 st020778 55.3625 µM 0.305127736569595 0.336199803606081 no 1131 0.380134433565316 1806 4259299
SGTC_2756 carbadox 75.1 µM 0.303635590824051 0.336735764680733 no 1132 0.380702766696122 1756 2553 A substituted quinoxaline antibiotic. YLR208W SEC13
SGTC_2406 ethylparaben 405.7 µM 0.302816527110485 0.337030103773409 no 1133 0.381014843803143 1539 8434 A possible steroid mimic.
SGTC_891 0929-0073 133 µM 0.301602232917247 0.337466656699019 no 1134 0.381477652798688 1849 5603632
SGTC_1869 3',7'-dimethoxyflavone 40.3 µM 0.300638905618344 0.337813139816702 no 1135 0.381844930360463 1727 688664
SGTC_2201 6605497 169.863 µM 0.299530545782385 0.338211957351743 no 1136 0.38226763453153 1876 670741
SGTC_1485 3909-9022 254 µM 0.299314723279745 0.338289637202728 no 1137 0.382349960848951 1868 714516
SGTC_2914 7968218 45.32 µM 0.299112480027264 0.33836243579357 no 1138 0.382427112136582 1877 2977111
SGTC_1357 1503-1303 39.5 µM 0.298784239835135 0.338480600548104 no 1139 0.382552338378317 1775 292895
SGTC_2227 7312221 64.1025 µM 0.298239423478795 0.338676766695089 no 1140 0.382760217252775 1849 887188 YOR168W | YOR169C GLN4 | YOR169C
SGTC_3207 9114163 49.47 µM 0.297387594787729 0.338983563165474 no 1141 0.383085306722505 1945 849233
SGTC_2120 5538279 151.968 µM 0.293972982054166 0.340214448092639 no 1142 0.384389274420828 1803 2058197
SGTC_3046 9092212 49.47 µM 0.293652766602712 0.340329965606264 no 1143 0.384511625243693 1785 25236637
SGTC_2515 chrysin 20.77 µM 0.291286934805151 0.341183901589175 no 1144 0.385415939471635 1876 5281607 Chrysin is a naturally occurring flavone and aromatase inhibitor.
SGTC_1569 carminic acid 40.6 µM 0.291157075062664 0.341230797464421 no 1145 0.385465595078016 1931 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1450 4112-4260 37.6 µM 0.291068322893403 0.34126284969074 no 1146 0.385499533101929 1903 1633175
SGTC_3259 9138485 49.47 µM 0.287044136995601 0.342717356360317 no 1147 0.38703926256149 1899 17646153
SGTC_1803 st050068 52.4 µM 0.286242341815869 0.343007437813634 no 1148 0.38734625786739 1827 3984059 YIL048W | YNL267W NEO1 | PIK1
SGTC_481 bay k-8644 50 µM 0.285608084448676 0.343236971344667 no 1149 0.387589155393625 1765 2303 A calcium channel antagonist.
SGTC_268 camptothecin 39.6153 µM 0.285333296280949 0.343336433322395 no 1150 0.387694402945062 1807 24360 Camptothecin is a Topo I (topoisomerase I) inhibitor and antineoplastic.
SGTC_829 1635-0120 117 µM 0.285254863413627 0.343364824774863 no 1151 0.387724445298765 1911 285054
SGTC_1406 3909-7906 11.9 µM 0.283526885700705 0.343990549274302 no 1152 0.388386487511487 1847 X1406
SGTC_3193 9111931 49.47 µM 0.282932645918556 0.344205830542553 no 1153 0.388614234386451 1804 17087244
SGTC_397 arbidol 50 µM 0.282648512416429 0.344308784315244 no 1154 0.388723144229664 1907 131410 A RNA synthesis inhibitor.
SGTC_912 3474-0017 2.18 µM 0.278496220057746 0.345814651111706 no 1155 0.390315733137384 1897 3360550
SGTC_3243 9134147 49.47 µM 0.278489503065851 0.345817089075171 no 1156 0.390318310902397 1931 24282180
SGTC_263 alizarin 107.927 µM 0.275531903990315 0.346891183279264 no 1157 0.391453809084302 1841 6293 Alizarin, an anthraquinone, binds to and calcium and forms precipitates; used as a biological stain to quantify free calcium.
SGTC_176 1486-1328 72.834 µM 0.274809731676969 0.347153637833466 no 1158 0.391731210532583 1768 22310231
SGTC_1850 st056238 17 µM 0.274529748279797 0.347255410174994 no 1159 0.391838772813411 1894 5393177
SGTC_803 4488-1585 147 µM 0.274433439183035 0.347290420519812 no 1160 0.391875774154989 1911 747204
SGTC_1286 0929-0070 131 µM 0.272913820770782 0.347843005501467 no 1161 0.392459731118599 1893 1420408
SGTC_650 1328-0195 38 µM 0.269812510848824 0.348971749651706 no 1162 0.393652248702859 1933 2780821
SGTC_2236 dapsone 200 µM 0.268865299395465 0.349316761242576 no 1163 0.394016670530961 1953 2955 A bacterial DFR inhibitor. An anti-cancer agent.
SGTC_324 1315-0088 19.6 µM 0.26801452915088 0.349626751345101 no 1164 0.394344067548146 1868 6787421
SGTC_2311 7694451 200 µM 0.267411248593688 0.349846625887149 no 1165 0.394576269787846 1872 2163142
SGTC_441 propafenone 146 µM 0.267269720591518 0.349898215161812 no 1166 0.39463074923921 1829 4932 Slows the influx of sodium ions into the cardiac muscle.
SGTC_2439 5492030 7.2 µM 0.266977286878887 0.350004820816808 no 1167 0.394743324501699 1951 5722370
SGTC_203 k066-0004 30.888 µM 0.266933839703723 0.350020660336764 no 1168 0.394760050673501 1981 6795412
SGTC_3169 9102970 49.47 µM 0.266566226602637 0.350154691346477 no 1169 0.394901581096971 1876 17027839
SGTC_1790 st045711 43.5 µM 0.26359956670018 0.35123701157682 no 1170 0.396044246221877 1958 585119
SGTC_89 0302-0250 142.109 µM 0.262194076446364 0.351750195752683 no 1171 0.396585910001841 1894 4203518 YLR208W SEC13
SGTC_1176 0848-0131 83.3 µM 0.259842394445141 0.352609465254733 no 1172 0.39749267388483 1987 6769040
SGTC_2810 7959871 45.46 µM 0.259316634383803 0.352801673223984 no 1173 0.397695472946619 1902 2974535
SGTC_1899 st063254 59.6 µM 0.25905601778935 0.352896963671971 no 1174 0.397796009666113 1771 3093813
SGTC_2240 6690706 185.951 µM 0.258813302015447 0.352985717259449 no 1175 0.397889646983073 1739 805876
SGTC_906 1165-0455 526 µM 0.258428811384231 0.353126329861319 no 1176 0.398037991659084 1806 3252859
SGTC_484 loperamide 105 µM 0.258219297485138 0.353202959923365 no 1177 0.398118832790471 1873 3955 An opioid-receptor agonist.
SGTC_1781 st038725 66.3 µM 0.256402311733267 0.353867774892046 no 1178 0.398820101502328 1790 4270275 YIL048W NEO1
SGTC_159 3970-0959 50 µM 0.253563490135416 0.35490736011454 no 1179 0.399916402790468 1945 6615653
SGTC_2355 9061122 103.12 µM 0.253389166162273 0.354971233404725 no 1180 0.399983749350379 1949 5302957
SGTC_2199 6590217 200 µM 0.25239498689782 0.355335584177431 no 1181 0.400367887312334 1933 703109
SGTC_492 tmb-8 126 µM 0.251972211452183 0.355490564708709 no 1182 0.40053127149112 1979 5494 TMB-8 is a protein kinase C (PKC) inhibitor which also serves as an intracellular Ca2+ and Na+ channel-blocker resulting in reduced membrane K+ conductance. YKL104C GFA1
SGTC_2904 7225135 42.03 µM 0.251791838963482 0.355556692720067 no 1183 0.400600982850692 1986 4446116
SGTC_2735 sertaconazole 140 nM 0.250627844633124 0.355983539839844 no 1184 0.401050925882626 1958 65863 A topical antifungal; lanosterol 14-alpha-demethylase inhibitor. YJL195C YJL195C
SGTC_2793 7325131 81.82 µM 0.249768507531964 0.356298782336448 no 1185 0.401383187663129 1880 4176441
SGTC_1620 st003704 16.5 µM 0.247500526231699 0.357131248484613 no 1186 0.402260442145491 1983 2834414
SGTC_557 1315-0110 16.2 µM 0.246232623653273 0.357596931000259 no 1187 0.402751081405026 1836 6833801
SGTC_647 0140-0236 81 µM 0.245975516187624 0.357691388787977 no 1188 0.402850592785014 1897 990837
SGTC_154 3389-1638 511.116 µM 0.245825850016748 0.357746378118696 no 1189 0.402908522773096 1731 5238686
SGTC_1603 st002045 67.8 µM 0.244387392584503 0.358275036812543 no 1190 0.403465402534631 1989 5887985
SGTC_3247 9135149 49.47 µM 0.243187929425869 0.358716068728372 no 1191 0.40392990857698 1897 8934436 YOR116C RPO31
SGTC_2865 9030313 51.95 µM 0.242159257923266 0.359094452217846 no 1192 0.404328381534074 1795 42562754
SGTC_3284 9108171 64.8615 µM 0.241660857274442 0.359277832191526 no 1193 0.404521481012496 1887 8687505
SGTC_233 rapamycin 362 pM 0.238854417398043 0.360311029074561 no 1194 0.405609236104252 1993 5284616 Rapamycin is an potent immunosuppressive and anticancer drug. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. that acts by inhibiting TOR. TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. YBR088C | YGR114C POL30 | YGR114C
SGTC_575 k072-0246 11.9 µM 0.238796247887907 0.360332455130817 no 1195 0.405631789914794 1881 6796779
SGTC_1140 3229-1848 2.98 µM 0.237980758833609 0.360632877102947 no 1196 0.405948008879936 1997 2849525
SGTC_1442 4112-3290 3 µM 0.237479852739866 0.360817450997483 no 1197 0.406142273694864 1912 704353
SGTC_2084 5306078 60.6385 µM 0.237397797928458 0.360847689648924 no 1198 0.406174098955192 1930 679340
SGTC_1265 0819-1001 68.8 µM 0.236886517340485 0.361036125191961 no 1199 0.40637241496953 1916 3106768
SGTC_2745 rifampicin 24.3 µM 0.236825343985694 0.361058673260879 no 1200 0.40639614456009 2016 25141428 Inhibits bacterial DNA-dependent RNA polymerase.
SGTC_952 1185-0122 232 µM 0.233133124025418 0.362420490986109 no 1201 0.40782901710541 1906 678600
SGTC_2497 7-hydroxyflavone 100 µM 0.231436909646641 0.363046698487153 no 1202 0.408487696820501 1985 5281894
SGTC_880 0833-0487 87.2 µM 0.230031553841443 0.363565804555989 no 1203 0.409033625333105 1854 76075
SGTC_300 r073-0011 5.04 µM 0.229864671870363 0.363627463576672 no 1204 0.409098464522874 2036 2735780
SGTC_1763 st044482 94.5 µM 0.228470941161393 0.364142552575771 no 1205 0.409640072170729 1950 88505
SGTC_1427 4048-4900 550 nM 0.227879476120377 0.364361217938858 no 1206 0.409869969328655 2029 24132586
SGTC_1057 3448-5381 134 µM 0.227662055007479 0.364441609897465 no 1207 0.409954486759013 1999 5497911
SGTC_988 1497-1057 103 µM 0.226801213752366 0.364759966453543 no 1208 0.410289159929265 2056 3533044
SGTC_2131 toluylene red 5.2905 µM 0.22617391178384 0.364992014209245 no 1209 0.41053308014238 1858 11105 A phenazine natural dye and potentional inhibitor of the electron transport chain.
SGTC_1711 st032263 62.8 µM 0.226016292803332 0.365050327447935 no 1210 0.410594374180025 1946 3958979
SGTC_565 1418-0001 44.5 µM 0.225996282729246 0.365057730664332 no 1211 0.410602155748309 1984 2862145
SGTC_1177 0983-0204 23.6 µM 0.225078138114129 0.365397474786234 no 1212 0.410959243954646 2047 766818
SGTC_1255 0566-0045 221 µM 0.223182044397281 0.36609942679549 no 1213 0.411696913007333 1944 2788469
SGTC_1441 4106-0040 13 µM 0.223131262899025 0.366118232766712 no 1214 0.411716673687268 1997 2904180
SGTC_237 nikkomycin 200 µM 0.222287995596847 0.36643056790709 no 1215 0.412044848240504 2005 353481 Nikkomycin inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine.
SGTC_54 0159-0055 9 µM 0.220667353630475 0.367031080722186 no 1216 0.412675726434732 2040 3319099
SGTC_1144 3486-0183 12.5 µM 0.220658446934823 0.367034381910582 no 1217 0.412679194228962 1925 6744069
SGTC_3323 9138564 53.9225 µM 0.220003745410578 0.367277068178385 no 1218 0.412934118875429 2031 43912313 YNL103W MET4
SGTC_873 0591-4978 488 µM 0.2181612866141 0.367960319374021 no 1219 0.41365172368908 2067 3305145
SGTC_939 1165-0479 45.3 µM 0.217651195950293 0.36814955363992 no 1220 0.413850445989241 2047 1377347
SGTC_1476 4112-3294 3.34 µM 0.217034111466471 0.368378523411557 no 1221 0.414090880675637 1998 704369
SGTC_1120 ficusin 1.78878 µM 0.216348814552646 0.368632858255897 no 1222 0.414357930713419 1984 6199 A DNA cross-linker.
SGTC_2946 9065502 71.43 µM 0.215669622875648 0.368884984049105 no 1223 0.414622640700408 2021 16489101
SGTC_839 0122-0028 230 µM 0.215134255850858 0.369083759827491 no 1224 0.414831323417198 1946 759448
SGTC_1671 st016596 74.5 µM 0.214803479245454 0.369206590979324 no 1225 0.414960270085494 1936 2829167
SGTC_930 2810-3379 265 µM 0.214690555767515 0.369248527235813 no 1226 0.415004293151698 2045 1015764
SGTC_2010 4012422 159 µM 0.214376089038992 0.369365318566301 no 1227 0.415126893206259 1949 952393
SGTC_1511 0906-3109 28.5 µM 0.214112947863161 0.369463057116202 no 1228 0.415229489497629 1997 2882180
SGTC_93 0109-0045 59.227 µM 0.214029092447345 0.369494205313576 no 1229 0.415262185157427 2047 88733
SGTC_1380 2291-0730 164 µM 0.211352402358399 0.37048891417962 no 1230 0.416306147579416 1874 2999191
SGTC_3218 9131285 49.47 µM 0.211092852445587 0.370585414046144 no 1231 0.41640740874642 2029 17156417
SGTC_2833 9001315 45.46 µM 0.210870081641869 0.370668246046121 no 1232 0.416494325285041 1894 2989378
SGTC_1297 1068-0111 14.1 µM 0.210296389948763 0.370881587183899 no 1233 0.416718176348644 1876 767057
SGTC_903 1134-0042 114 µM 0.210285238197281 0.37088573462607 no 1234 0.416722527963131 1906 701009
SGTC_1610 st001799 48.1 µM 0.210152264671167 0.370935189897618 no 1235 0.416774417416609 1850 621897
SGTC_3279 9140807 49.47 µM 0.209981581043339 0.370998673366028 no 1236 0.416841024379689 2034 45595718
SGTC_2773 thioridazine 9.09 µM 0.209871533250368 0.371039606016978 no 1237 0.416883970299254 2057 5452 An antipsychotic.
SGTC_3192 9110362 49.47 µM 0.209494181034817 0.371179974534403 no 1238 0.417031238735866 1970 16649480
SGTC_1907 st060210 83.7 µM 0.208742582216639 0.371459607382912 no 1239 0.417324598256776 2021 688793
SGTC_576 1073-0113 22.7 µM 0.208485450172355 0.371555289119091 no 1240 0.417424971061795 2055 5439563
SGTC_2172 5754775 163.918 µM 0.207641316072686 0.371869456711823 no 1241 0.417754520907906 1876 2263357
SGTC_3191 9110352 49.47 µM 0.207193467479806 0.372036170476202 no 1242 0.417929384410529 1970 17122424
SGTC_756 0508-1999 28.3 µM 0.203940484639965 0.373247827016379 no 1243 0.419200003845952 1844 6753853
SGTC_536 3852-0578 10.6 µM 0.203192944121417 0.373526445277184 no 1244 0.419492113789407 2060 2869208
SGTC_681 1642-0006 26.6 µM 0.200285236648373 0.374610813992473 no 1245 0.42062875403647 2042 4446530
SGTC_823 0417-1665 178 µM 0.199787574114462 0.374796506522269 no 1246 0.420823359915419 1948 3429856
SGTC_1712 st032288 53.4 µM 0.198467362347082 0.375289256930413 no 1247 0.421339708947356 1979 2883011
SGTC_3111 9122088 49.47 µM 0.1983790211002 0.375322236329033 no 1248 0.421374264999505 2053 16876704
SGTC_655 k060-0012 42 µM 0.198125812604713 0.375416768726927 no 1249 0.421473314793766 1942 5994525
SGTC_3021 9087658 49.47 µM 0.196752420232369 0.375929638732136 no 1250 0.42201064318196 2080 25237042
SGTC_1440 4100-1550 40 µM 0.196569298469747 0.375998039022001 no 1251 0.422082299047861 2032 742806
SGTC_1016 4226-1401 38 µM 0.195367870871411 0.376446897054675 no 1252 0.422552483636713 2069 2901613
SGTC_583 1488-1091 88.9 µM 0.195310035484138 0.376468508801728 no 1253 0.422575120589233 2102 4303273
SGTC_1195 1502-0147 41.1 µM 0.194547693716792 0.37675341446366 no 1254 0.422873527426477 1939 817940
SGTC_3130 9127414 49.47 µM 0.193901529128468 0.376994954463236 no 1255 0.423126493176013 2112 1494646
SGTC_4 0960-0234 25.671 µM 0.192341131994613 0.377578438132244 no 1256 0.423737500585426 1954 6821112
SGTC_333 3486-0131 40.1 µM 0.192172128369483 0.37764165092979 no 1257 0.423803688661361 2067 6744690
SGTC_1397 3532-0190 20.1 µM 0.191879506107388 0.377751108827059 no 1258 0.423918295454047 1980 5322280
SGTC_860 0443-0016 25.1 µM 0.191637460284248 0.377841655587299 no 1259 0.424013098625851 2101 5337942
SGTC_1466 k213-0079 57.5 µM 0.191523145427601 0.377884421889563 no 1260 0.424057874367057 1961 3657981
SGTC_1434 4073-0095 163 µM 0.190651647231675 0.378210507024487 no 1261 0.424399261812065 2051 24133745
SGTC_960 1222-0186 7.7 µM 0.190047612029394 0.378436567483601 no 1262 0.424635910672172 2004 3126296
SGTC_1541 2',3',6-trimethoxyflavone 64 µM 0.188779923875507 0.378911135592697 no 1263 0.425132653669235 2067 688801
SGTC_305 1682-2595 20.8 µM 0.188207501834711 0.379125485755924 no 1264 0.425356995981831 1995 226033
SGTC_2151 5563267 85.4165 µM 0.186533931174392 0.379752386950903 no 1265 0.426013036271559 1961 5310824
SGTC_2012 4023501 200 µM 0.185927734573582 0.379979539633047 no 1266 0.426250716180417 1945 3477460
SGTC_995 3931-2021 34.6 µM 0.185245462879031 0.380235248541265 no 1267 0.426518255946322 1977 730143
SGTC_2594 a-mangostin 100 µM 0.18382419058808 0.380768095814977 no 1268 0.427075689083787 2062 45934201 Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis, reduce cell proliferation and inhibit tumorigenesis.
SGTC_1856 st057054 55.7 µM 0.183778943297743 0.380785063136502 no 1269 0.42709343779215 2088 1266018
SGTC_3299 9121982 43.1275 µM 0.18284346000456 0.381135912173393 no 1270 0.427460423615958 1957 17594604 YPL160W CDC60
SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 15.32 µM 0.181813394340847 0.381522346971802 no 1271 0.427864586278405 1896 5711223 A potent inhibitor of glutathione S-transferases.
SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.94 µM 0.181420507597098 0.381669771736562 no 1272 0.428018761612618 2043 4000243
SGTC_2970 9090938 41.86 µM 0.180091627023798 0.38216854103234 no 1273 0.428540317904198 2120 17217104
SGTC_3272 9137413 49.47 µM 0.178875323850924 0.382625228080912 no 1274 0.429017799491909 2107 17614870
SGTC_1625 st003711 30.1 µM 0.177073723275353 0.383301977421548 no 1275 0.429725240770591 2046 24207034 YER133W GLC7
SGTC_3253 9135987 49.47 µM 0.175944906182453 0.383726185507652 no 1276 0.430168612789407 2038 4182430
SGTC_3276 9139060 49.47 µM 0.175833149126024 0.383768191264295 no 1277 0.430212513054892 2076 4870619
SGTC_2847 9005661 71.43 µM 0.174974702230847 0.384090898376605 no 1278 0.43054975580211 2121 2991449
SGTC_2491 paeonol 100 µM 0.174596147575958 0.384233230084849 no 1279 0.430698487939096 1970 11092 Increases levels of cortical cytochrome oxidase.
SGTC_2195 6536160 144.242 µM 0.173567500464484 0.384620067040009 no 1280 0.431102687580243 1962 3834386
SGTC_531 3788-1495 174 µM 0.173368306971063 0.38469498979701 no 1281 0.431180967615228 1944 2896655
SGTC_486 niguldipine 82 µM 0.173104151981355 0.384794353198763 no 1282 0.431284780706349 2025 1236 A calcium channel blocker.
SGTC_1368 1852-0141 284 µM 0.170986871477415 0.385591053193513 no 1283 0.432117044307978 1998 2838987
SGTC_2077 5212015 200 µM 0.166918219340102 0.387123377363686 no 1284 0.433717198652388 2117 780900
SGTC_2782 7736369 71.43 µM 0.166072568364184 0.387442085823032 no 1285 0.43404992081533 1983 2950836 YOL077C BRX1
SGTC_729 4092-0585 94.1 µM 0.165905779268427 0.387504954167271 no 1286 0.434115549664774 1955 2169061
SGTC_3138 9097216 49.47 µM 0.165631746900608 0.387608252463343 no 1287 0.434223380973794 2176 25237486
SGTC_2312 7706453 155.7 µM 0.165369648707141 0.387707059538412 no 1288 0.434326520783261 1990 976098
SGTC_804 1595-0054 20.9 µM 0.165240489129611 0.387755753430909 no 1289 0.434377348776874 1971 761523 Stimulates phospholipase C.
SGTC_2719 novobiocin 32.65 µM 0.164906842965777 0.387881548093258 no 1290 0.43450865311839 2099 54675769 An antibiotic compound derived from Streptomyces niveus, novobiocin has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, inhibiting DNA replication.
SGTC_1045 1348-1485 165 µM 0.164894116901312 0.387886346436279 no 1291 0.43451366152385 2113 6810614
SGTC_3022 9087993 49.47 µM 0.164889931651257 0.387887924482111 no 1292 0.434515308651956 2101 17173644
SGTC_1558 st069300 45.6 µM 0.164511009107208 0.388030804652122 no 1293 0.434664440403448 2119 24208000
SGTC_2142 5622915 118.518 µM 0.16392009348009 0.388253651213463 no 1294 0.434897024373955 1987 5322196
SGTC_3294 9122953 26.2835 µM 0.163814649442238 0.388293420221864 no 1295 0.434938529443351 2092 16459826
SGTC_290 2043-6722 48.1 µM 0.163794714323717 0.388300939032741 no 1296 0.434946376420697 2074 773758 YLR208W SEC13
SGTC_125 0133-0007 11.75 µM 0.163754375891604 0.388316153368913 no 1297 0.434962254747431 2138 26541
SGTC_642 0335-0876 158 µM 0.162363960593296 0.388840677115885 no 1298 0.435509624752301 2014 6812350
SGTC_2728 chlorpromazine 9.18 µM 0.161453800003014 0.389184138207721 no 1299 0.435867998076185 2127 2726 A thorazine and dopamine antagonist.
SGTC_398 bronopol 33.3 µM 0.160816732616353 0.389424595521471 no 1300 0.436118873024429 2032 2450 Metabolized to formaldehyde. Reacts with secondary amines and cross-links them.
SGTC_2596 sinensetin 100 µM 0.16020085086996 0.389657096696938 no 1301 0.436361429577141 2003 145659 Isolated from citrus fruit, sinensetin exhibits antiadhesive action on platelets.
SGTC_3047 9092122 49.47 µM 0.159797733103196 0.389809298851924 no 1302 0.436520204928394 1998 17173831
SGTC_954 1189-0853 2.85 µM 0.158561598482057 0.3902761222038 no 1303 0.43700714296038 2136 2828194
SGTC_1792 st045773 43.6 µM 0.157505413919656 0.390675113241513 no 1304 0.437423270729716 2001 2919270
SGTC_2191 5911152 200 µM 0.157034449486558 0.390853064920885 no 1305 0.437608849071329 2073 2875902
SGTC_2803 7707263 71.43 µM 0.155580380332855 0.391402622140522 no 1306 0.43818189541637 2005 2199229
SGTC_749 1000-0129 128 µM 0.155243323247823 0.391530041959046 no 1307 0.438314747631785 2137 708470
SGTC_1984 st072354 53.1 µM 0.15403647232027 0.391986370792552 no 1308 0.438790489001414 2048 5762938
SGTC_1097 itavastatin 7.23 µM 0.153997802390754 0.392000994946183 no 1309 0.438805734177188 2059 5282451 Itavastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W HSH49
SGTC_1992 st073643 23.3 µM 0.153450850034893 0.39220785714914 no 1310 0.439021373577199 2113 3161292
SGTC_612 0302-0167 22.4 µM 0.152626608670027 0.392519650033995 no 1311 0.439346370078926 2095 235821
SGTC_1038 k292-0204 154 µM 0.15229930787306 0.392643480077784 no 1312 0.439475435394963 2065 4454212
SGTC_1636 st007707 68.9 µM 0.150934805747121 0.393159838860075 no 1313 0.440013571990629 2106 403051
SGTC_2811 7967822 32.47 µM 0.149835990048528 0.393575792544959 no 1314 0.440447006961233 2087 2232244
SGTC_1467 k284-1082 293 µM 0.149210993101288 0.393812437664255 no 1315 0.440693572929871 2167 3334705
SGTC_2344 7990960 76.95 µM 0.147894110324403 0.394311182588499 no 1316 0.44121316818653 2026 140813
SGTC_1404 3909-7820 48.3 µM 0.147745171435532 0.394367601355472 no 1317 0.441271940578645 2143 23741373
SGTC_2361 9034121 116 µM 0.147536115293391 0.394446796565186 no 1318 0.441354437866952 2020 6496917
SGTC_2071 5230951 39.92 µM 0.147488428516664 0.394464862009387 no 1319 0.44137325627747 2122 1799272
SGTC_1929 genistein trimethyl ether 50.5 µM 0.147335792940194 0.394522687311112 no 1320 0.441433491033463 2183 136420
SGTC_3306 9127676 59.7925 µM 0.146916522780802 0.394681537882924 no 1321 0.441598955073494 2004 41905287
SGTC_1986 st071812 45 µM 0.146690184751017 0.394767298763049 no 1322 0.441688283113926 2154 11838594
SGTC_1335 1486-0900 202 µM 0.146461073185346 0.394854115746804 no 1323 0.441778708796689 2157 X1335
SGTC_3146 9095609 49.47 µM 0.14567227860329 0.395153052683018 no 1324 0.442090053179324 2067 17173999
SGTC_1836 st055642 81 µM 0.143494974480839 0.395978526006753 no 1325 0.442949639980724 1959 8571
SGTC_3326 9140064 16.379 µM 0.141101700367627 0.396886417587394 no 1326 0.443894800196701 2105 1868434
SGTC_2743 auranofin 4.32 µM 0.140531998360683 0.39710261734988 no 1327 0.444119836151894 2121 16667669 Auranofin is used to treat rheumatoid arthritis and is thought to inhibit selenocysteine-containing flavoreductases (thioredoxin reductase and thioredoxin glutathione reductase) more effectively than non Se-containing ones (glutathione reductase); this preference has been ascribed to the high affinity of selenium for gold.
SGTC_2385 9074692 200 µM 0.139500894293599 0.397493997827958 no 1328 0.444527174652939 2005 17046906
SGTC_2533 agelasine 13.65 µM 0.138876277268554 0.397731136548968 no 1329 0.444773958643446 2177 16667745 Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges (Agelas sp.) that have been associated with inhibition of Na/K-ATPase.
SGTC_2614 arthonioic acid 13.39 µM 0.138676419004077 0.397807021641872 no 1330 0.444852926466428 2152 6710684
SGTC_477 mead ethanolamide 10 µM 0.138252543687242 0.397967977581137 no 1331 0.445020414951166 2154 16061185
SGTC_2829 7992743 58.44 µM 0.137257982156075 0.398345705321305 no 1332 0.445413440703768 2207 16462845
SGTC_2585 alliin 100 µM 0.134735771485516 0.399304050262499 no 1333 0.446410394750692 2110 87310 A garlic compound which reacts with lipids.
SGTC_1296 1068-0102 11.9 µM 0.134514282177586 0.399388236929802 no 1334 0.446497959090302 2142 767053
SGTC_3165 9101544 49.47 µM 0.134119060829904 0.399538469653324 no 1335 0.446654213726229 2136 5002184
SGTC_3005 9076496 71.4286 µM 0.133504773150916 0.399772004049538 no 1336 0.446897094817627 2189 21368410
SGTC_2450 5739737 12.93 µM 0.133215216884131 0.399882097401259 no 1337 0.44701158838667 2072 2262825
SGTC_2455 5377712 9.75 µM 0.133166686055063 0.399900550281778 no 1338 0.44703077841524 1985 2243908
SGTC_2021 4019055 173 µM 0.132240578032103 0.400252727188167 no 1339 0.447397003155001 2144 44827708 YER133W GLC7
SGTC_3054 9094397 49.47 µM 0.130686535329996 0.400843874902318 no 1340 0.448011642118327 2101 2598354
SGTC_3233 9132340 49.47 µM 0.130655010839137 0.400855868968144 no 1341 0.448024111657107 2051 17682950
SGTC_2143 5623677 140.463 µM 0.129298083324422 0.401372225163435 no 1342 0.448560893995011 2156 5375313
SGTC_505 gw-5074 63.9 µM 0.127348965578899 0.402114230771597 no 1343 0.449332103415531 2147 5924208 A c-Raf1 kinase inhibitor, which inhibits other kinases.
SGTC_1522 st012842 45.6 µM 0.126610693707195 0.402395374261956 no 1344 0.449624266353239 2031 3491067 YOR116C RPO31
SGTC_2730 imipramine 71.33 µM 0.125703732070118 0.40274082610553 no 1345 0.449983223769792 2197 3696 A tricyclic antidepressant.
SGTC_192 3455-0609 60.9 µM 0.125206958515016 0.402930073969994 no 1346 0.450179854250239 2124 3769639
SGTC_1752 st044819 83.042 µM 0.125113099198793 0.402965832606093 no 1347 0.450217006561194 2080 441209 YML126C ERG13
SGTC_2238 6671620 73.2395 µM 0.123237161251736 0.403680699550637 no 1348 0.450959649708217 2215 729941
SGTC_2737 bleomycin 30.5 nM 0.121371564176493 0.404391945139493 no 1349 0.451698369423842 2156 16211318 Bleomycin acts by induction of DNA strand breaks.
SGTC_2367 9070478 135.38 µM 0.117950053919316 0.405697191422944 no 1350 0.453053616363007 2122 572802
SGTC_2987 9018338 71.43 µM 0.117876003667768 0.405725451949103 no 1351 0.453082953484612 2221 5055682
SGTC_240 5hr heat shock (37°C) + Streptovitacin 300 µM 0.117234511815254 0.405970291347823 no 1352 0.453337109500408 2182 91467 include heat shock
SGTC_3256 9138902 49.47 µM 0.117183384561892 0.405989806766377 no 1353 0.453357366698401 2199 17228773
SGTC_2382 9035899 200 µM 0.116819980583181 0.406128525830908 no 1354 0.453501354972873 2109 6462679
SGTC_2586 curcumin 80 µM 0.116632251664794 0.406200190588401 no 1355 0.453575739501454 2167 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. YMR203W TOM40
SGTC_114 0364-0001 490.298 µM 0.115740478789364 0.406540664170696 no 1356 0.453929112189881 2044 4003655
SGTC_2900 5328528 85.29 µM 0.115221408469958 0.40673887468726 no 1357 0.454134815090078 2175 795359
SGTC_1423 4048-0112 5.59 µM 0.115071024134833 0.406796304430243 no 1358 0.454194413350831 2211 X1423
SGTC_1355 1499-0035 1.68 µM 0.114900679539377 0.40686135914765 no 1359 0.454261923234374 2122 1548538
SGTC_148 3253-0744 288.01 µM 0.113503193916767 0.407395156734783 no 1360 0.454815815533727 2232 6893655
SGTC_1722 st034304 3.6505 µM 0.113112170273247 0.407544546877914 no 1361 0.454970813217377 2112 4036148 YLR033W RSC58
SGTC_63 0099-0242 26.702 µM 0.112261931931762 0.407869425858649 no 1362 0.455307862434053 2233 3898502 YLR359W ADE13
SGTC_2464 5717415 7.67 µM 0.111949459994787 0.407988838388539 no 1363 0.455431739823632 2143 5285744
SGTC_2423 st077119 87.2 µM 0.111947127740289 0.407989729702038 no 1364 0.455432664446488 2196 107936 An active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae).
SGTC_3236 9132701 49.47 µM 0.11069251087465 0.408469273276084 no 1365 0.455930092469889 2097 24282524
SGTC_1952 st077036 64.1 µM 0.110230737625682 0.408645808241195 no 1366 0.456113192852316 2226 2937007
SGTC_2471 5466956 24.79 µM 0.110002345493373 0.408733128938422 no 1367 0.456203757385323 2120 724419
SGTC_13 0199-0087 65 µM 0.109481229199828 0.408932383221414 no 1368 0.456410404598405 2220 4589825
SGTC_2691 st077356 60.2 µM 0.108463066153998 0.409321756418582 no 1369 0.456814188285592 2180 2839272
SGTC_379 3970-0972 5.9 µM 0.108323770342824 0.40937503388596 no 1370 0.456869433775654 2115 2898042 YBL034C STU1
SGTC_2802 7925815 54.55 µM 0.107448610713134 0.409709800718663 no 1371 0.457216545959419 2141 1262923
SGTC_1755 st041960 45.185 µM 0.106611324632908 0.410030141755508 no 1372 0.45754866701756 2131 2257073
SGTC_2624 nerol 100 µM 0.105545811957551 0.410437887842959 no 1373 0.457971360139758 2181 637566 A natural product oil.
SGTC_1863 st057641 20.1 µM 0.10539014464554 0.410497466098139 no 1374 0.45803311797372 2250 3921635
SGTC_77 0828-0286 12.516 µM 0.104981772838173 0.410653771278774 no 1375 0.458195135978385 2218 745345
SGTC_1939 st074455 53.6 µM 0.104324672315755 0.410905307682992 no 1376 0.45845584953214 2225 1644229
SGTC_2572 astragaloside iv 100 µM 0.101330972317462 0.412051750646553 no 1377 0.459643865185167 2121 45006101 An anti-inflammatory agent.
SGTC_463 ikarugamyin 104 µM 0.100956982603806 0.412195023670351 no 1378 0.459792304274667 2225 54714554 An antiprotozoal antibiotic found to inhibit cholesteryl ester accumulation in macrophage. Shown to be efficient inhibitor of clathrin-dependent endocytosis.
SGTC_2774 tamoxifen 10.92 µM 0.0998072826195094 0.412635539456508 no 1379 0.460248663114772 2210 2733526 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen.
SGTC_1494 4358-1428 177 µM 0.0992519743149299 0.41284834926432 no 1380 0.460469104502412 2251 1564571
SGTC_1053 3366-3204 134 µM 0.098550317916784 0.413117280415385 no 1381 0.460747659230708 2124 3632071 YPR165W RHO1
SGTC_2300 7976697 71.57 µM 0.0978337921818012 0.413391952772332 no 1382 0.461032136903018 2140 2236109
SGTC_2444 5485484 36.41 µM 0.0964057326575887 0.413939510189569 no 1383 0.461599169665464 2197 6790631
SGTC_709 3807-1509 243 µM 0.0963857838501362 0.41394716030034 no 1384 0.461607091198564 2227 1886677 YPL242C IQG1
SGTC_3305 9127027 53.8275 µM 0.0958356127628965 0.414158156687098 no 1385 0.461825566313741 2160 41905295
SGTC_1759 st043059 70 µM 0.093369398415413 0.41510427942745 no 1386 0.462805050409032 2159 669426
SGTC_2203 7227154 166.4 µM 0.0915757578454594 0.415792689963757 no 1387 0.463517556468334 2252 896304
SGTC_2053 5265679 138 µM 0.0907986998407098 0.416091010091233 no 1388 0.463826271581037 2213 764595
SGTC_1189 1431-2119 7.28 µM 0.0905941594527249 0.416169543181613 no 1389 0.463907536465362 2245 3107275
SGTC_2531 methyl deoxycholate 70.07 µM 0.0902604656566743 0.416297671785284 no 1390 0.464040117853501 2169 16667744 Haematoxylin.
SGTC_2755 lomerizine 42.69 µM 0.0891914060807043 0.41670821905531 no 1391 0.464464897556141 2180 3949 A calcium channel blocker.
SGTC_2725 haloperidol 53.21 µM 0.088112669973767 0.417122574472553 no 1392 0.464893563182906 2251 3559 Haloperidol is a D2, D3, and D4 dopamine antagonist of the typical antipsychotic class of medications. It is a butyrophenone derivative and has pharmacological effects similar to the phenothiazines.
SGTC_862 0452-0056 10.2 µM 0.087982958361136 0.417172404461537 no 1393 0.464945110433752 2230 1575396 YLR359W | YHR072W ADE13 | ERG7
SGTC_845 0330-0138 4.51 µM 0.0871812950199542 0.417480400792804 no 1394 0.465263703575622 2253 9039800
SGTC_214 4373-3496 70 µM 0.0870451086435593 0.417532728172491 no 1395 0.465317828320531 2194 3779166
SGTC_898 1000-0849 28.3 µM 0.0865609539090732 0.417718768500551 no 1396 0.465510251812221 2248 6751807
SGTC_3352 9151559 45.5865 µM 0.0854429506077356 0.418148440508949 no 1397 0.465954624169643 2176 17159339
SGTC_1633 st005664 67.9 µM 0.0850784566123685 0.418288544305171 no 1398 0.466099508665575 2226 2063822
SGTC_341 1486-1430 230 µM 0.0848014885033835 0.418395011932119 no 1399 0.466209605075269 2256 2054753 YPL210C SRP72
SGTC_2067 5224629 34.075 µM 0.0844542361871795 0.418528505530455 no 1400 0.466347643512359 2158 2835000
SGTC_2229 7354935 190 µM 0.0843886212260185 0.418553730829309 no 1401 0.466373726980634 2250 318112
SGTC_3171 9103192 49.47 µM 0.0834620074337799 0.418909997950663 no 1402 0.46674209281509 2261 13018434
SGTC_1077 5-fluorocytosine 377 nM 0.0831157534355657 0.419043143764264 no 1403 0.466879749878928 2193 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1084 voriconazole 435 nM 0.08223756242235 0.419380878039706 no 1404 0.467228902049109 2257 71616 Voriconazole is an antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YJL195C YJL195C
SGTC_2519 cryptotanshinone 88.04 µM 0.0818296460868383 0.419537774526809 no 1405 0.467391090477439 2252 160254 Cryptotanshinone is a natural product that exhibits antitumor activity via inhibition STAT3 activity. Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also inhibits acetylcholinesterase (AChE)
SGTC_378 3970-0959 8.33 µM 0.0812853593299585 0.419747142962992 no 1406 0.467607508510592 2191 6615653
SGTC_1572 epiandrosterone 68.9 µM 0.0803341078078649 0.420113111292337 no 1407 0.467985765878756 2189 441302 A steroid.
SGTC_2350 9023895 38.85 µM 0.0768030308664864 0.421472199525604 no 1408 0.469390119790034 2219 2997209
SGTC_2339 9000433 200 µM 0.0765898078117979 0.421554297803778 no 1409 0.469474933662297 2155 2988954
SGTC_143 4032-1194 15.74 µM 0.0759409774221755 0.421804140990274 no 1410 0.469733027849697 2252 1806963
SGTC_260 nsc-65238 3.989 µM 0.0754816949425052 0.421981014560838 no 1411 0.469915730651668 2258 3246252
SGTC_2389 9091542 195.52 µM 0.0754518698732727 0.421992500992021 no 1412 0.469927595298672 2133 3626624 YOL127W RPL25
SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 85.4 µM 0.0752647160636317 0.422064580439753 no 1413 0.470002047164433 2223 688761
SGTC_1681 tripelennamine 100 µM 0.0752148123468479 0.422083800539406 no 1414 0.47002189959488 2288 9066 Tripelennamine acts primarily as an antihistamine, or H1 receptor antagonist.
SGTC_1209 2323-2347 50.3 µM 0.0738257892947235 0.422618848253725 no 1415 0.470574503062767 2287 5412760
SGTC_1223 0764-0573 147 µM 0.0738080691466957 0.422625674928719 no 1416 0.470581553145106 2266 1609797
SGTC_2019 4016004 108 µM 0.0736371854772939 0.422691508938652 no 1417 0.470649540857027 2203 45595336
SGTC_676 falcarinol 140 µM 0.0732764968447926 0.422830473592984 no 1418 0.470793047105835 2272 3322 Farnesol is a natural pesticide found in carrots. Preliminary research in animal models suggest that falcarinol may have a protective effect against certain types of cancer.
SGTC_3255 9139072 49.47 µM 0.0726281420772253 0.423080293225151 no 1419 0.471051015856535 2190 17646060
SGTC_719 2810-4230 27.3 µM 0.0716821173119946 0.42344486449667 no 1420 0.471427443932588 2284 721079
SGTC_706 4262-0057 46.9 µM 0.0716799060646751 0.423445716725949 no 1421 0.471428323829201 2265 883298
SGTC_1137 ixabepilone 100 µM 0.0705937784024677 0.423864360693427 no 1422 0.471860531088026 2290 154225 A novel microtubule stabilizer.
SGTC_3028 9087778 49.47 µM 0.0702504295374795 0.423996721168507 no 1423 0.471997168235678 2267 17217395
SGTC_323 4013-0906 34.3 µM 0.0690218259445502 0.424470416150116 no 1424 0.472486123167956 2286 2910086
SGTC_1847 st056231 15 µM 0.0685348877824353 0.424658188110581 no 1425 0.472679924459475 2281 5393180
SGTC_3092 9117248 49.47 µM 0.0649165956615469 0.426053998282808 no 1426 0.474120203518955 2312 17141857
SGTC_2072 5231554 129 µM 0.0648429710193306 0.426082409768456 no 1427 0.474149513747607 2299 789545
SGTC_1100 amiodarone 5.07 µM 0.0641887341983184 0.426334894250078 no 1428 0.474409973851902 2308 441325 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
SGTC_3052 9092717 49.47 µM 0.0626888757244698 0.426913836656507 no 1429 0.475007127928187 2232 25237534
SGTC_1272 0839-0021 27 µM 0.0624723772370997 0.426997417679862 no 1430 0.475093329366054 2228 5027250
SGTC_2294 7971431 200 µM 0.0620879177087196 0.427145849521504 no 1431 0.4752464093534 2260 5741572
SGTC_1780 st038448 24.544 µM 0.0615866899345474 0.42733937864572 no 1432 0.475445988357233 2251 728868 YDL195W SEC31
SGTC_20 0481-0013 4.944 µM 0.061377565408927 0.427420128917498 no 1433 0.475529259438886 2263 182045
SGTC_244 nsc-207895 1.295 µM 0.0601544028654783 0.427892495427615 no 1434 0.476016330576063 2283 42640
SGTC_1901 st060216 58.6 µM 0.05926389052592 0.428236462617691 no 1435 0.476370960863265 2306 688792
SGTC_2852 9023854 51.95 µM 0.0565127157268295 0.429299468243249 no 1436 0.477466683014548 2285 19798528
SGTC_2039 Aminomethylbenzodioxan 200 µM 0.0564784135964811 0.429312725237274 no 1437 0.477480345763212 2284 15053
SGTC_2335 9018011 154.17 µM 0.05608722459111 0.429463916535297 no 1438 0.477636160608859 2267 6458208
SGTC_2707 st078556 66.6 µM 0.0556675033191581 0.429626146823129 no 1439 0.477803343968554 2312 17250899
SGTC_2652 actinonin 100 µM 0.0555616701457367 0.429667055243188 no 1440 0.477845500051635 2328 443600 A inhibitor of aminopeptidase M, N and leucine. Also an alanyl aminopeptidase and peptide deformylase.
SGTC_1139 k015-0024 46.9 µM 0.0552939932073109 0.42977052560976 no 1441 0.477952123786588 2304 2766652
SGTC_2896 9052656 71.43 µM 0.0537874369117665 0.430352973861294 no 1442 0.478552259461202 2299 6469436
SGTC_459 nigericin 15.3 µM 0.0533412822601736 0.430525490419364 no 1443 0.478729994257811 2254 34230 Nigericin is a polyether antibioitc and K+/Na+ ionophore, stimulates Ca2+ release from mitochondrial stores by disruption of membrane potential leading to rapid intracellular acidification.
SGTC_1825 st052143 62.6 µM 0.0524732135787549 0.430861188280253 no 1444 0.479075819194826 2300 674173
SGTC_2964 9083345 53.42 µM 0.0518015022413036 0.431120985505122 no 1445 0.479343429272463 2267 17741579
SGTC_3167 9103034 49.47 µM 0.0508468647746525 0.431490261083566 no 1446 0.479723773230236 2305 5127859
SGTC_2677 mitomycin C 100 µM 0.0505293067587495 0.431613113067276 no 1447 0.479850297905495 2312 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_3119 9125183 49.47 µM 0.0501038169409326 0.431777730421628 no 1448 0.480019829040767 2318 22695334
SGTC_1917 st066507 28.5 µM 0.0477075034246882 0.432705058346828 no 1449 0.480974677022934 2232 3156428
SGTC_1866 st057638 64 µM 0.0466643084445602 0.433108871172917 no 1450 0.481390388537817 2280 688802
SGTC_3075 9116269 49.47 µM 0.0461500298615134 0.433307970225779 no 1451 0.481595335198219 2272 17015205 YNL244C SUI1
SGTC_1307 1187-1599 12.2 µM 0.0455775576190737 0.433529618419351 no 1452 0.481823478502443 2268 1538471
SGTC_2149 5554786 194.827 µM 0.044085928236826 0.434107241324891 no 1453 0.482417954759862 2291 745063 YPR165W RHO1
SGTC_721 1187-1332 279 µM 0.0436222181801676 0.434286838488767 no 1454 0.482602770503237 2310 25730
SGTC_3332 9141069 11.198 µM 0.0427829524935508 0.434611924643227 no 1455 0.482937276742777 2323 17332883
SGTC_11 0438-0307 1.3 µM 0.0426967554372711 0.434645315230297 no 1456 0.482971632999425 2339 4011476
SGTC_3216 9129716 49.47 µM 0.0423865679749587 0.434765477962662 no 1457 0.483095267965017 2305 8056934
SGTC_1839 st053978 48 µM 0.0420622054129546 0.434891138396001 no 1458 0.483224554600731 2334 3788398
SGTC_2937 9044753 11.33 µM 0.041785431254719 0.434998367933747 no 1459 0.483334874522102 2331 6465530 YGL099W LSG1
SGTC_1246 0422-0085 105 µM 0.0413435421837702 0.435169577207718 no 1460 0.483511010541717 2325 264295
SGTC_2600 tangeritin 87.95 µM 0.040441567255398 0.435519083766621 no 1461 0.483870545731067 2335 68077 A bioactive flavone.
SGTC_1157 4092-0394 27.6 µM 0.0403785236258531 0.435543514449801 no 1462 0.483895675973532 2331 3659885
SGTC_1597 7-benzyloxygramine 47.5 µM 0.0399353704477696 0.435715252217966 no 1463 0.48407232602288 2345 260807
SGTC_2895 9054447 58.44 µM 0.039818603851862 0.435760505485823 no 1464 0.484118872131975 2308 2697450
SGTC_1997 st073024 93.8 µM 0.0393235659927039 0.435952368327183 no 1465 0.484316209099786 2337 686268
SGTC_1648 st011736 69.8 µM 0.0387834871891262 0.436161704971911 no 1466 0.484531505121678 2317 2855514
SGTC_2658 polymyxin b sulfate 77.05 µM 0.038328456968612 0.436338090338715 no 1467 0.484712901035593 2320 5702105 Polymyxin B (PMB) acts selectively on Gram-negative bacteria by electrostatic and hydrophobic interactions with anionic cell envelope components such as phospholipids and lipopolysaccharides. YIL048W NEO1
SGTC_3340 9146634 11.102 µM 0.0365160131564008 0.437040781214274 no 1468 0.485435455286092 2284 4907387
SGTC_2383 9036125 200 µM 0.0361445379260573 0.437184828080015 no 1469 0.485583554691107 2251 79580
SGTC_508 roscovitine 141 µM 0.0348585676112063 0.437683552690152 no 1470 0.486096259387602 2343 160355 A CDKinase inhibitor.
SGTC_552 k242-0005 476 µM 0.0337406632424129 0.438117178496201 no 1471 0.486541976420499 2306 4088318
SGTC_386 1509-0011 3.07 µM 0.0321080194167879 0.438750600834675 no 1472 0.487192954069606 2346 3107280
SGTC_616 4092-0450 108 µM 0.0300549848863176 0.439547346096755 no 1473 0.488011600676935 2319 787165
SGTC_1451 4152-0210 104 µM 0.0291123098216984 0.439913263345483 no 1474 0.488387509070937 2354 659563
SGTC_3330 9141424 71.43 µM 0.0290380837985509 0.439942077771715 no 1475 0.488417108456052 2343 27261020
SGTC_2189 6047310 154.431 µM 0.0286185787426865 0.44010493495424 no 1476 0.488584397229443 2326 711535
SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 61.9 µM 0.0274149147084259 0.440572268755915 no 1477 0.489064401251448 2362 66535 A nucleotide analog.
SGTC_370 0180-0345 38.7 µM 0.0270553113049053 0.440711904226098 no 1478 0.489207809056184 2312 3989527
SGTC_2487 5918373 44.05 µM 0.0268925302533524 0.440775115198147 no 1479 0.489272725679308 2369 2876279
SGTC_2079 5212404 121 µM 0.0255464466176773 0.441297882711285 no 1480 0.489809550758996 2360 758462
SGTC_697 0508-1955 564 µM 0.0250158194410657 0.44150398621602 no 1481 0.490021172734009 2360 6243113
SGTC_179 1273-0063 6.77 µM 0.024568209244407 0.441677857007782 no 1482 0.490199688494856 2359 3108139
SGTC_1000 4048-0884 8.67 µM 0.0238287467485562 0.441965120219665 no 1483 0.490494604983279 2334 13040088
SGTC_2785 7756463 72.73 µM 0.0236036605549721 0.442052566803239 no 1484 0.49058437613263 2357 2201551
SGTC_282 k297-0036 65.7 µM 0.0232302070663453 0.442197660702333 no 1485 0.490733321675191 2341 5061378
SGTC_1715 st032160 10.2275 µM 0.0227398815396266 0.442388173418991 no 1486 0.490928881591826 2350 5289825
SGTC_3211 9128781 49.47 µM 0.0222216086448911 0.442589559383644 no 1487 0.491135590319778 2268 17194361
SGTC_1685 st024049 53.0905 µM 0.0210955269210256 0.443027173471508 no 1488 0.491584726551079 2328 1941139
SGTC_3096 9117468 49.47 µM 0.018241151234894 0.444136741531087 no 1489 0.49272323707597 2369 41316311
SGTC_1003 4049-0218 100 µM 0.016952903700197 0.4446376599182 no 1490 0.493237093884236 2361 295161
SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 100 µM 0.0160155682966183 0.44500218628899 no 1491 0.493610985791673 2384 5024745
SGTC_1978 st071761 42 µM 0.0156857773842231 0.445130451867062 no 1492 0.493742536802996 2331 5147680
SGTC_3286 9117135 37.221 µM 0.0146302708047731 0.445541008586013 no 1493 0.494163574612437 2369 3438150
SGTC_1960 st011366 51.8 µM 0.0142007615027612 0.445708090068298 no 1494 0.49433490622863 2379 3972846
SGTC_2622 2-methoxyxanthone 59.94 µM 0.012657714259966 0.446308423276011 no 1495 0.494950437447061 2374 71034 A hepatoprotective.
SGTC_78 0336-0123 156.75 µM 0.0125996025682179 0.446331034445501 no 1496 0.494973618809292 2360 6765896
SGTC_2962 9082311 13.18 µM 0.0110141603743911 0.44694799463712 no 1497 0.495606074582828 2378 16459453
SGTC_3036 9090181 49.47 µM 0.0098149561338797 0.447414739278572 no 1498 0.496084461884171 2385 25236586
SGTC_2576 guaiol 23.12 µM 0.00979994151260041 0.447420583611851 no 1499 0.496090451563354 2388 227829
SGTC_2486 5283202 22.39 µM 0.00953397822496153 0.447524109798536 no 1500 0.496196550605916 2374 1377751
SGTC_2049 5262831 67.185 µM 0.00924485728398144 0.44763665415517 no 1501 0.496311888088765 2387 763417
SGTC_15 0266-0086 27.098 µM 0.00894109543691082 0.447754902229933 no 1502 0.496433066522514 2391 1712902 YIL048W NEO1
SGTC_2089 5281248 129.67 µM 0.00777302981591783 0.448209648683415 no 1503 0.496899040986294 2389 2737878
SGTC_2394 5221648 200 µM 0.00688281321844441 0.448556269847276 no 1504 0.497254176478777 2383 788586
SGTC_1674 st016616 23.6 µM 0.00621689138189669 0.448815583675484 no 1505 0.497519835151396 2390 625830
SGTC_2016 5121758 140 µM 0.00607792272527429 0.448869701638471 no 1506 0.497575274576573 2403 2795203
SGTC_2925 9010536 32.5 µM 0.00598924033371035 0.448904237336026 no 1507 0.497610653088116 2389 2994177
SGTC_1111 tnp00062 510.699 nM 0.00581870521756795 0.448970650132997 no 1508 0.497678685570445 2387 676306
SGTC_2326 6164455 177.58 µM 0.00525912850221909 0.449188580414128 no 1509 0.497901920954001 2392 2888790
SGTC_2478 5763493 32.33 µM 0.00424157422583101 0.449584911855045 no 1510 0.498307861779719 2393 1365576 YLR208W SEC13
SGTC_3301 9125354 19.7965 µM 0.00423105027455536 0.449589011136003 no 1511 0.498312060191167 2394 41905162
SGTC_494 Boc-Gly-Val-Val-CHO 140 µM 0.00358556412958713 0.449840450642944 no 1512 0.498569569934617 2396 6610324 An aldehyde inhibitor of gamma-secretase. The exact mechanism of DNA strand scission is unresolved, but it has been suggested that bleomycin chelates metal ions (primarily iron), producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
SGTC_3229 9132204 49.47 µM 0.00158022058375502 0.450621730354619 no 1513 0.499369583459148 2399 17682924
SGTC_1745 st081495 74 µM 0.000602408586694863 0.451002754462979 no 1514 0.499759673759226 2403 13842402 YBL026W LSM2
SGTC_1657 st012939 43.4 µM 0.000294672765451043 0.451122679272303 no 1515 0.49988244257668 2404 24207257
SGTC_1069 diphenylcyclopropenone 8.49 µM 0 0.451237517583658 no 1516 0.5 2405 65057 A dermal irritant. YDR527W RBA50
SGTC_90 0870-0863 4.608 µM -0.00206590509997887 0.452042745264505 no 1517 0.499175823694581 2408 1738164
SGTC_757 1066-0008 322 µM -0.00266160602663553 0.452274968368452 no 1518 0.498938174075892 2419 6842497
SGTC_1448 4255-0083 152 µM -0.0040496825618033 0.452816147816662 no 1519 0.498384414819807 2414 5399660
SGTC_944 3370-0224 231 µM -0.00543177619885538 0.453355081763129 no 1520 0.497833045472311 2424 4580514
SGTC_227 fluconazole 33.516 µM -0.00577635399602673 0.453489459936963 no 1521 0.497695580979402 2413 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YCR093W | YER133W | YOR174W | YJL195C CDC39 | GLC7 | MED4 | YJL195C
SGTC_319 1348-1596 45.5 µM -0.00593060828669796 0.453549617628435 no 1522 0.497634043475228 2418 5380505
SGTC_1382 3002-2117 298 µM -0.00785464874157885 0.454300064043178 no 1523 0.496866480739992 2410 1497314
SGTC_855 0428-0020 25 µM -0.00920234994085645 0.45482581432299 no 1524 0.49632884534383 2433 6812414
SGTC_2607 solasodine 47.35 µM -0.0097591141610566 0.455043036174227 no 1525 0.496106738541226 2428 6710642 Solasodine is a steroidal glycoalkaloid with teratogenic activity.
SGTC_1281 0884-0031 11.8 µM -0.00982953297463356 0.455070511070113 no 1526 0.496078646846593 2421 1548255
SGTC_1072 oxiconazole 14.9 nM -0.00988325896376769 0.45509147316904 no 1527 0.496057214319069 2427 47316 Oxiconazole is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_1353 1498-1206 8.11 µM -0.0100036154714906 0.455138432739997 no 1528 0.49600920139307 2421 6756808
SGTC_1471 k673-0312 37 µM -0.0108946998662992 0.455486127132477 no 1529 0.495653729570941 2426 24099884
SGTC_1906 st060206 94.7 µM -0.0135095990685713 0.456506636891167 no 1530 0.494610613676265 2429 5133468
SGTC_408 cantharidin 100 µM -0.0150793312325586 0.457119390350566 no 1531 0.493984445187741 2452 2545 Cantharidin is a toxic blistering agent secreted by the Spanish fly of unknown mechanism. In Saccharomyces cerevisiae, cantharidin is thought to act by inhibiting GLC7 (encoding type 1 serine/threonine protein phosphatase) as decreased expression confers hypersensitivity and overexpression confers resisitance (Hoon et al., Nat Chem Biol 4, 2008). YER133W GLC7
SGTC_879 0831-1030 162 µM -0.0166239119198324 0.457722425327579 no 1532 0.49336832411977 2440 1549252
SGTC_1701 st028638 40.4 µM -0.0169228869396407 0.457839162400719 no 1533 0.493249067121504 2440 3490878
SGTC_2703 st077852 53.4 µM -0.0176312059499688 0.458115745449975 no 1534 0.492966530897338 2446 6281836
SGTC_540 1187-0821 17.3 µM -0.017875852081326 0.458211279121501 no 1535 0.492868946591949 2438 847520
SGTC_1845 st056753 3.01 µM -0.0187936649895237 0.458569704122669 no 1536 0.492502853768889 2425 5375839
SGTC_2303 7774051 200 µM -0.0188577020447912 0.458594713183184 no 1537 0.492477311206659 2468 2953184
SGTC_3087 9117406 49.47 µM -0.0190124638841509 0.458655154618377 no 1538 0.49241558123285 2495 42546093
SGTC_2230 bromochlorosalicylanilide 954.5 nM -0.0190240450474857 0.458659677620223 no 1539 0.492410961852616 2439 77254
SGTC_594 1487-1584 10.8 µM -0.0195074394870342 0.458848471188316 no 1540 0.492218151160426 2439 5013332
SGTC_39 0986-0283 58.349 µM -0.019538620823355 0.458860649627972 no 1541 0.492205713977443 2445 3110600 YBR109C | YER133W | YKL058W CMD1 | GLC7 | TOA2
SGTC_2308 7584454 197.62 µM -0.0200476988084326 0.459059484773635 no 1542 0.492002661026205 2443 893577
SGTC_375 3970-0961 9.27 µM -0.02093286976733 0.459405238277388 no 1543 0.491649603040628 2455 2898222
SGTC_1130 3454-2858 15.9 µM -0.0217794612605429 0.459735951123884 no 1544 0.491311938920525 2502 715628 YIL048W NEO1
SGTC_1226 3909-7979 35.4 µM -0.0218025449545041 0.459744968938741 no 1545 0.491302732045208 2462 6615510
SGTC_2231 micatex 6.853 µM -0.0218292540637754 0.459755403074602 no 1546 0.491292079187576 2462 20737 An antifungal of unknown mechanism.
SGTC_2942 9052777 62.25 µM -0.0220980999419905 0.459860431497225 no 1547 0.491184851066876 2454 6469503
SGTC_1851 st056236 18.9 µM -0.0226123667904226 0.460061344870197 no 1548 0.490979739539197 2448 5393171
SGTC_537 1334-0398 209 µM -0.0228433089216437 0.460151572483887 no 1549 0.490887630751613 2442 5846986
SGTC_2351 9026858 72.31 µM -0.0236723530032454 0.460475491576794 no 1550 0.490556979465762 2456 1409300
SGTC_156 3474-0145 5.642 µM -0.0238190773352315 0.460532821559029 no 1551 0.490498461426508 2431 2265471
SGTC_2116 5511452 16.8835 µM -0.0266924851013836 0.461655719572111 no 1552 0.489352503509348 2485 870744
SGTC_295 k015-0027 31 µM -0.0268022196542514 0.461698608817249 no 1553 0.489308741413568 2493 3887424
SGTC_252 miconazole 1.30953 nM -0.0269122241209295 0.461741604004024 no 1554 0.489264871805454 2449 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YDL196W YDL196W
SGTC_767 0929-0023 86 µM -0.0280824442520107 0.462199011492372 no 1555 0.488798198004581 2458 1204563
SGTC_633 0437-0093 97.7 µM -0.029554876496347 0.46277461650358 no 1556 0.488211026458385 2451 2831118
SGTC_1170 0310-0127 64.8 µM -0.0303072233645039 0.463068755028097 no 1557 0.487911017904318 2488 774975
SGTC_1075 aripiprazole 15.2 µM -0.0307420136783109 0.463238750440101 no 1558 0.487737642456703 2464 60795 An atypical antipschotic. YIL048W NEO1
SGTC_2173 5763948 167 µM -0.0310298766386473 0.463351303520915 no 1559 0.487622856513862 2464 2867177
SGTC_2888 9058547 12.99 µM -0.0312304783276985 0.463429739584911 no 1560 0.487542866786646 2477 16476514
SGTC_3157 9099274 49.47 µM -0.0313047281780414 0.463458771934469 no 1561 0.487513259858375 2463 17217662
SGTC_2644 guaiazulene 100 µM -0.0327888068938814 0.464039100480411 no 1562 0.486921502109707 2477 3515 A coloring agent.
SGTC_2547 epiafzelechin trimethyl ether 100 µM -0.0343045079423128 0.464631873478001 no 1563 0.48631716508441 2456 6708630 An antioxidant.
SGTC_3114 9122766 49.47 µM -0.0352247934302413 0.46499182478408 no 1564 0.485950246098828 2511 17176985
SGTC_1159 4092-0538 61.2 µM -0.0352793091899267 0.46501314843742 no 1565 0.485928510966742 2459 717301
SGTC_247 mechlorethamine 29.705 µM -0.0353320088292362 0.465033761816981 no 1566 0.485907499951549 2463 22133593 Mechlorethamine, a bifunctional alkylating agent, binds to the N7 position on guanine inducing DNA damage and interstrand cross-links.
SGTC_711 k292-0785 179 µM -0.0362946694986149 0.465410321453431 no 1567 0.485523700132518 2469 4146315
SGTC_2302 7771753 200 µM -0.0364586281451113 0.465474459514729 no 1568 0.485458333359214 2501 2203047
SGTC_2188 6126565 140.678 µM -0.0375771097833411 0.465912015901471 no 1569 0.485012429387935 2476 874518
SGTC_1158 4092-0494 91.8 µM -0.0381657589283143 0.466142315384562 no 1570 0.48477776070568 2565 1148199
SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 70.1 µM -0.0409256738055598 0.467222237502301 no 1571 0.483677574926458 2493 551469
SGTC_2537 larixol 68.93 µM -0.0416580254420928 0.467508838893638 no 1572 0.483385657868901 2476 6708759
SGTC_345 1362-0200 395 µM -0.0418544370604031 0.46758570626529 no 1573 0.483307369251225 2505 1419823
SGTC_739 1486-1183 203 µM -0.0424092965481529 0.467802861806423 no 1574 0.483086208722235 2466 4346692
SGTC_3355 9151058 44.0485 µM -0.0427307324704412 0.467928666676965 no 1575 0.482958090483884 2482 17015728
SGTC_2352 9027995 87.8 µM -0.0442262968201913 0.468514048526986 no 1576 0.482362010362894 2518 2997347
SGTC_2047 4141938 200 µM -0.0453886043503359 0.46896903673588 no 1577 0.481898782019359 2496 3807862
SGTC_1528 arabinosylhypoxanthine 74.6 µM -0.0456566225925453 0.469073958923471 no 1578 0.481791968943115 2584 804 An inhibitor of viral and cellular DNA polymerases.
SGTC_430 0958-0115 16.4 µM -0.045929413198861 0.469180751573229 no 1579 0.481683255282973 2534 6833180
SGTC_1364 1653-0028 37.6 µM -0.0460837928010491 0.469241189412918 no 1580 0.481621731877407 2539 5718652
SGTC_2331 7980721 200 µM -0.0461516856823072 0.469267768919983 no 1581 0.481594675324403 2554 2981221
SGTC_1804 st050076 49.1 µM -0.0462222889216526 0.469295409655312 no 1582 0.48156653873413 2536 3895976
SGTC_2264 7948757 110.76 µM -0.0465847468240913 0.469437312028842 no 1583 0.481422094551371 2477 2971411
SGTC_250 brefeldin a 552.239 µM -0.0467238902232669 0.469491787741997 no 1584 0.481366644746024 2477 6436187 Brefeldin A inhibits transport of proteins from ER to Golgi and induces retrograde protein transport from the Golgi apparatus to the endoplasmic reticulum.
SGTC_867 0518-0118 155 µM -0.0475642801249379 0.469820818969932 no 1585 0.481031750061498 2505 6848158
SGTC_2065 5221596 34.26 µM -0.0479038163681791 0.469953760774266 no 1586 0.480896448931305 2551 788581
SGTC_3104 9120930 49.47 µM -0.0479429065337386 0.469969066328055 no 1587 0.480880872109033 2543 17014836
SGTC_2844 9010103 25.97 µM -0.0488899043673469 0.470339871976193 no 1588 0.480503517195084 2596 2480525
SGTC_2280 7785178 200 µM -0.0491234144059822 0.470431308929194 no 1589 0.480410471966258 2511 2954328
SGTC_438 sphingosine 6.67 µM -0.0506598836905803 0.471032992253067 no 1590 0.479798271877664 2515 5280335 A constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
SGTC_741 4582-0002 126 µM -0.0508298004527538 0.471099535958919 no 1591 0.479730572118063 2503 2912688
SGTC_764 1951-2361 146 µM -0.0515494049767837 0.471381360231496 no 1592 0.479443867337703 2502 5438930
SGTC_554 4483-2211 187 µM -0.0525101309380569 0.471757639068329 no 1593 0.479061111575793 2563 747107
SGTC_490 phenamil 164 µM -0.0526455504977256 0.471810679655834 no 1594 0.479007161609883 2528 4755 Irreversibly blocks amiloride-sensitive Na+ channels.
SGTC_1390 3413-2614 145 µM -0.0528247963651275 0.471880886723657 no 1595 0.478935752218656 2519 3421432
SGTC_3309 9129340 25.759 µM -0.054132601162264 0.472393154351752 no 1596 0.478414759173133 2557 17158987
SGTC_516 3992-2719 87.3 µM -0.054377366338856 0.472489034061824 no 1597 0.478317255607229 2490 5350887 YDR037W KRS1
SGTC_2453 5731132 22.18 µM -0.0544649827151401 0.472523355642116 no 1598 0.478282353452803 2527 1362040
SGTC_736 0958-0254 92.6 µM -0.0560018423009285 0.47312541587985 no 1599 0.477670169761238 2562 6812352
SGTC_1437 4092-1038 11.6 µM -0.0566173807902229 0.473366568575879 no 1600 0.47742499444235 2506 3977136
SGTC_181 1447-1644 8.07 µM -0.0571157093799385 0.473561808497783 no 1601 0.477226511287829 2497 534600
SGTC_3141 9094609 49.47 µM -0.0577493932941345 0.473810088384708 no 1602 0.476974124578222 2516 25236309 YDL196W YDL196W
SGTC_2545 solidagenone 89.61 µM -0.058936526049323 0.474275239042584 no 1603 0.476501332511266 2494 6708572 An anti ulcer agent
SGTC_901 1112-0062 60.1 µM -0.0615465223797975 0.475298028485365 no 1604 0.475461982551806 2495 1908457
SGTC_2872 9044037 25.97 µM -0.0633888496158296 0.476020086861203 no 1605 0.474728433056454 2523 6465195
SGTC_1617 st002906 78 µM -0.0634938728688024 0.476061250738308 no 1606 0.474686619071757 2529 5150859
SGTC_922 1866-0035 480 µM -0.0638600746622829 0.476204785572627 no 1607 0.474540821580526 2525 3156169
SGTC_2059 5238311 157 µM -0.0670868609047118 0.477469673804936 no 1608 0.473256276904462 2535 703021
SGTC_1020 4335-0961 93.3 µM -0.0692594819870061 0.478321461870184 no 1609 0.472391538472811 2523 669075
SGTC_1670 st016595 4.04 µM -0.0694200090424796 0.478384401363171 no 1610 0.472327651213042 2518 597879
SGTC_1650 st011916 45.8 µM -0.0712344989257953 0.479095864176089 no 1611 0.471605562487333 2543 242528
SGTC_1694 st024011 44.9 µM -0.0721864366228557 0.479469146428568 no 1612 0.471226769509951 2541 2787533
SGTC_2123 5259487 200 µM -0.072522411315336 0.479600896120844 no 1613 0.471093085388048 2570 2173474
SGTC_3186 9110464 49.47 µM -0.0741083313174956 0.480222831360599 no 1614 0.470462093029976 2609 17018021
SGTC_81 0411-0046 9.971 µM -0.0745576440367684 0.48039904289641 no 1615 0.470283337720112 2523 12925265
SGTC_291 SEC14.278 35.5 µM -0.0746747061478553 0.48044495296466 no 1616 0.470236766519505 2542 1068044
SGTC_506 n9-isopropylolomoucine 153 µM -0.0759921970637985 0.480961671606621 no 1617 0.469712653044679 2529 6610355
SGTC_2992 9074591 71.4286 µM -0.0765850374341655 0.48119419350467 no 1618 0.469476831194345 2539 17741321
SGTC_514 4466-0038 2.65 nM -0.077247857432503 0.481454170153913 no 1619 0.469213185315088 2610 5722064
SGTC_921 1561-0023 372 µM -0.0777344124128775 0.481645015730833 no 1620 0.469019659884839 2526 24050882
SGTC_3003 9075612 71.4286 µM -0.0781428710359217 0.481805232162429 no 1621 0.468857202639241 2618 6501993
SGTC_3015 9080845 49.47 µM -0.0782921485947236 0.481863786484693 no 1622 0.46879783140362 2625 5296973
SGTC_1099 5-nonyloxytryptamine 2.85 µM -0.0787142628268438 0.482029363470471 no 1623 0.46862995029327 2545 23581825 A 5-HT1D beta serotonin receptor agonist.
SGTC_1268 0828-0275 2.46 µM -0.0794952511846324 0.482335719260994 no 1624 0.468319354333385 2629 745337
SGTC_1315 1237-0019 3.69 µM -0.0796224618603056 0.482385620776116 no 1625 0.468268764975488 2551 825140
SGTC_2780 5215298 71.43 µM -0.080047518296951 0.48255236161089 no 1626 0.468099731529819 2567 2834131
SGTC_450 aminopyrene 156 nM -0.0800487265543947 0.482552835589619 no 1627 0.468099251046704 2538 15352 Aminopyrene is an established DNA mutagen. YPR165W RHO1
SGTC_3043 9092303 49.47 µM -0.0806281756099824 0.482780146372472 no 1628 0.467868829125716 2564 25236084
SGTC_828 2074-0507 139 µM -0.0820879878114759 0.483352837507244 no 1629 0.467288372611643 2639 X828
SGTC_1999 st074831 12.5 µM -0.0822215059972767 0.48340521904647 no 1630 0.467235286016194 2579 17112523
SGTC_2434 5670830 169.91 µM -0.0823995998810835 0.483475088863899 no 1631 0.467164477109023 2626 1549830
SGTC_1525 8-methoxypsoralen 92.5 µM -0.0825774505356297 0.483544863764009 no 1632 0.467093765945114 2576 4114 Related to psoralen; DNA damaging agent.
SGTC_2885 9057732 51.95 µM -0.0826295042403752 0.483565285724388 no 1633 0.467073070248851 2646 6471414
SGTC_857 0438-0306 1.35 µM -0.0831005178148901 0.483750077994152 no 1634 0.466885807057669 2616 4686136
SGTC_1458 k015-0034 6.33 µM -0.0844925163062833 0.484296219575869 no 1635 0.466332426344284 2590 3598957
SGTC_2174 5790901 200 µM -0.0845042908033093 0.48430083935053 no 1636 0.466327745739166 2606 786020
SGTC_872 0588-0139 234 µM -0.0853289245696913 0.484624393169924 no 1637 0.465999948451549 2587 2047100
SGTC_402 epigallocatechin gallate 10 µM -0.08665382478926 0.485144252956517 no 1638 0.465473340384779 2563 65064 An antioxidant.
SGTC_280 3448-3607 3.04 µM -0.0888028714288913 0.485987541784682 no 1639 0.464619287819567 2564 626179
SGTC_2807 7945238 51.95 µM -0.0907783590484242 0.486762781185996 no 1640 0.463834353008557 2647 17148797
SGTC_2714 st079313 56.9 µM -0.0920458829182552 0.487260221335535 no 1641 0.463330792500422 2571 2939799
SGTC_627 1391-0720 175 µM -0.0932336355225026 0.487726373230567 no 1642 0.462858976736517 2635 997839
SGTC_2465 5809242 33.21 µM -0.0964319507577556 0.48898168313687 no 1643 0.461588758662871 2585 2731748
SGTC_3320 9137005 35.139 µM -0.0969039330544537 0.4891669414768 no 1644 0.461401342691927 2633 4908713
SGTC_1910 st062352 60.4 µM -0.0974195067716231 0.48936931260731 no 1645 0.461196627122308 2558 2245730
SGTC_3116 9124943 49.47 µM -0.0976276710579999 0.48945102127853 no 1646 0.461113975566668 2585 41905195 YPL160W CDC60
SGTC_249 wiskostatin 11.211 µM -0.0978503903021993 0.489538443553729 no 1647 0.461025546830258 2560 2775510 A n-wasp and actin depolymerizer.
SGTC_2521 angolensin 13.4 µM -0.099011409459079 0.489994177534209 no 1648 0.460564605590626 2696 821428 A flavenoid.
SGTC_1227 3909-8010 46.6 µM -0.0992442596194777 0.490085579625112 no 1649 0.460472167099822 2599 15982272
SGTC_3025 9087895 49.47 µM -0.0993551670462232 0.49012911497581 no 1650 0.46042813904194 2615 17173641
SGTC_674 0498-0004 451 µM -0.0995432952878052 0.490202962679328 no 1651 0.460353456955484 2603 4231473
SGTC_1560 lithocholic acid 53.1 µM -0.101008189385892 0.490778002283402 no 1652 0.459771979619055 2589 9903 A bile acid which acts as a detergent.
SGTC_2681 menadione 3.18 µM -0.101667423030458 0.491036788717433 no 1653 0.459510330389261 2613 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_1966 st070145 16.1 µM -0.102131068505873 0.49121879801608 no 1654 0.459326320421572 2568 3748532
SGTC_2814 7977482 42.97 µM -0.103384971236615 0.491711040829005 no 1655 0.458828719721836 2684 6456762
SGTC_1328 1441-0025 69.2 µM -0.103833655457871 0.491887183261705 no 1656 0.458650678810921 2585 4562601
SGTC_2603 homopterocarpin 100 µM -0.104905220489553 0.492307859776644 no 1657 0.458225508238642 2679 101795 A weak amylase inhibitor.
SGTC_1401 3807-4679 7.6 µM -0.107434322959888 0.493300771483844 no 1658 0.457222213143652 2589 3291456
SGTC_1734 st037168 69.4 µM -0.107741506760766 0.493421373102614 no 1659 0.457100371749432 2704 708907
SGTC_2506 ethyl hematommate 54.16 µM -0.108263225234112 0.493626203284764 no 1660 0.456893446561008 2664 3940691 An allergen.
SGTC_2534 helenine 20.12 µM -0.108904988445316 0.493878166137863 no 1661 0.456638924987281 2603 72724 Natural product isolated from Penicillium funiculosum with antiviral properties. YLR033W RSC58
SGTC_1238 0333-0287 48.8 µM -0.109914372393454 0.494274465585128 no 1662 0.456238642043233 2618 7226
SGTC_1550 gossypolone 36.6 µM -0.112112726725598 0.495137591861967 no 1663 0.455367013289253 2617 5478622 Gossypolone is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
SGTC_1424 4048-1941 275 µM -0.113078594311005 0.495516821919961 no 1664 0.454984122697672 2700 X1424
SGTC_1576 erythromycin ethylsuccinate 23.2 µM -0.113400732084466 0.495643304281435 no 1665 0.454856429668529 2600 3256 An antibiotic and ribosome inhibitor.
SGTC_1582 3',3',6'-trihydroxyflavone 74 µM -0.115147680685657 0.496329223644453 no 1666 0.454164033747176 2605 688803
SGTC_2502 avocadyne acetate 18.59 µM -0.116118268962097 0.496710318835877 no 1667 0.453779405108522 2572 3952079
SGTC_2088 5278280 127.392 µM -0.116707778630899 0.496941787471373 no 1668 0.453545812974392 2660 791502
SGTC_1981 st071826 47 µM -0.116923538523737 0.49702650499982 no 1669 0.453460322522323 2696 11838600
SGTC_2950 9072895 21.46 µM -0.117401889639524 0.497214328722344 no 1670 0.453270793356639 2682 17332245
SGTC_2404 5161160 200 µM -0.117994813018617 0.497447139894551 no 1671 0.453035883891991 2594 2831543
SGTC_1660 st012960 28.1 µM -0.119561691065943 0.498062378026493 no 1672 0.45241518403494 2678 24207266
SGTC_1419 3993-2473 62.6 µM -0.119745756617792 0.498134652103393 no 1673 0.452342276287169 2641 704026
SGTC_388 3',4'-dichloroisocoumarin 16.7 µM -0.120482258122434 0.498423842960855 no 1674 0.452050566614492 2735 1609 A potent and irreversible inhibitor of serine proteases.
SGTC_2873 9040596 71.43 µM -0.122755807409212 0.499316567579049 no 1675 0.451150235039727 2734 6463863
SGTC_818 4072-2707 53.5 µM -0.123822252752811 0.499735316061104 no 1676 0.450728006126287 2627 882871
SGTC_1205 4161-2785 76 µM -0.124395914049522 0.499960569008795 no 1677 0.450500904168987 2777 3498106
SGTC_493 zm226600 134 µM -0.124496334629453 0.5 no 1678 0.450461151172838 2795 5240098 A potassium channel opener. YCR052W RSC6
SGTC_3124 9127567 49.47 µM -0.124656713556847 0.499937025856016 no 1679 0.45039766379436 2699 17592030
SGTC_1283 0922-0125 16.4 µM -0.125918194217274 0.499441694971978 no 1680 0.449898340202716 2720 3360884
SGTC_748 act1.228 77.9 µM -0.126571296639249 0.499185249158369 no 1681 0.449639858076646 2629 4421505 YNR035C ARC35
SGTC_772 k072-0172 35.3 µM -0.126974384855376 0.499026973554513 no 1682 0.449480336176127 2659 5861980
SGTC_673 1082-0474 110 µM -0.127242144858259 0.498921835669194 no 1683 0.44937437483979 2644 3098046
SGTC_3009 9080819 71.4286 µM -0.129265483854809 0.498127360039063 no 1684 0.44857379107071 2702 17027216
SGTC_2408 sulbentine 18.36 µM -0.129417581903791 0.498067638131028 no 1685 0.448513618162471 2763 67686 An antifungal agent of unknown mechanism. YDL205C HEM3
SGTC_382 3229-0966 23.2 µM -0.129628070723511 0.497984988924746 no 1686 0.448430346698388 2770 5722370
SGTC_2101 5377231 179.231 µM -0.129660773184603 0.49797214819125 no 1687 0.448417409484362 2739 2844213
SGTC_2197 6588183 93.1375 µM -0.129736131066764 0.497942558668413 no 1688 0.448387597837566 2652 884136
SGTC_343 4130-2827 29.8 µM -0.13019683484986 0.497761662049257 no 1689 0.448205349345241 2669 1118244
SGTC_1242 0402-0103 60.1 µM -0.130346079619714 0.49770306077303 no 1690 0.448146312375798 2647 432868
SGTC_1429 4049-0205 9.46 µM -0.131123701120798 0.497397726867736 no 1691 0.44783872612461 2611 22774478
SGTC_2045 5106652 78.05 µM -0.131321052099565 0.497320237032531 no 1692 0.447760669417968 2732 673349
SGTC_1954 st077032 68.9 µM -0.131491625308512 0.497253261566388 no 1693 0.447693205545274 2722 698907
SGTC_725 1497-0963 19 µM -0.131743358529747 0.497154418813053 no 1694 0.447593644620809 2694 3549977
SGTC_1488 4013-0813 75.9 µM -0.131755372826643 0.497149701417822 no 1695 0.447588893028106 2641 2910057
SGTC_3210 9128157 49.47 µM -0.132430290547224 0.496884696670586 no 1696 0.447321978636029 2790 17590849
SGTC_2931 9014674 55.67 µM -0.132757109759584 0.496756372414778 no 1697 0.447192737740727 2668 2996810
SGTC_2854 9024559 71.43 µM -0.133404889529167 0.496502025285368 no 1698 0.446936589344263 2726 3163529
SGTC_778 3456-2434 196 µM -0.13401124234304 0.496263945506488 no 1699 0.44669684226145 2823 5539063
SGTC_2474 5321570 43.32 µM -0.134087238197164 0.496234106409695 no 1700 0.446666795476809 2788 2841384
SGTC_666 0272-0154 136 µM -0.134379263291547 0.496119445548937 no 1701 0.446551339198128 2678 6870312
SGTC_1527 coumarin 137 µM -0.135877350602091 0.49553124113779 no 1702 0.445959120498066 2880 323 A hepatotoxic, DNA x-linker.
SGTC_2522 biochanin a 4.94 µM -0.137770359709817 0.494787989897457 no 1703 0.44521095523083 2757 5280373 A possible chelator.
SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 44.4 nM -0.138803716397045 0.494382271035639 no 1704 0.444802628578392 2785 5955 4-Nitroquinoline 1-oxide (also known as 4-NQO) is a quinoline derivative and a tumorigenic compound. 4-NQO induces DNA lesions that require nucleotide exicision repair.
SGTC_1151 3909-8316 15.3 µM -0.139086321930122 0.49427131480022 no 1705 0.444690968342374 2768 800431
SGTC_533 1222-0222 6.71 µM -0.139429884650947 0.494136426226752 no 1706 0.444555229231549 2830 3982874
SGTC_2446 5162541 200 µM -0.139600878729761 0.494069291289092 no 1707 0.444487673147762 2639 1549321
SGTC_2687 chenodiol 100 µM -0.141595844554815 0.493286049556701 no 1708 0.443699624712943 2737 5702181 A cholesterol synthesis inhibitor.
SGTC_2261 9010538 184.68 µM -0.141930574706145 0.493154633907766 no 1709 0.443567421828334 2780 6457250
SGTC_1594 piperine 70.1 µM -0.142268219235448 0.4930220748216 no 1710 0.443434074262506 2663 638024 Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.
SGTC_1125 tnp00248 1.32998 µM -0.143202722495599 0.492655193336223 no 1711 0.443065039871825 2818 24207736
SGTC_1396 3511-0007 98.6 µM -0.143259793701233 0.492632787653537 no 1712 0.443042504107341 2766 X1396
SGTC_40 0327-0103 19.753 µM -0.144064342764495 0.492316930860603 no 1713 0.442724830648547 2712 409036
SGTC_1041 0206-0046 107 µM -0.145093883582853 0.491912751922001 no 1714 0.442318373690966 2764 50494
SGTC_950 1165-0508 94.1 µM -0.145585698328153 0.491719677332538 no 1715 0.442124229382394 2750 6148369
SGTC_775 4577-0580 57.3 µM -0.146982001452115 0.491171533176556 no 1716 0.441573113388524 2885 2006902
SGTC_1923 st058458 19.1 µM -0.147993074598838 0.490774628393548 no 1717 0.44117411686437 2906 3534982
SGTC_3346 9158254 43.5805 µM -0.148717266614022 0.490490346665699 no 1718 0.440888367982796 2757 17639500
SGTC_1249 0481-0015 10.2 µM -0.148968117458867 0.490391876232893 no 1719 0.440789395396113 2670 4227577
SGTC_368 fentichlor 4.58 µM -0.150255246640749 0.489886628484932 no 1720 0.440281620034317 2750 7329 A pesticide.
SGTC_1800 st050079 29.0735 µM -0.15053128564268 0.489778274637059 no 1721 0.440172734785611 2748 3645560
SGTC_2463 5473429 200 µM -0.150844633471493 0.489655276835064 no 1722 0.440049138328567 2741 5399405
SGTC_2700 st077718 96.8 µM -0.151019821805209 0.489586510933762 no 1723 0.439980039845019 2743 904970
SGTC_1280 0880-0253 10.1 µM -0.15111438478545 0.489549392674142 no 1724 0.439942742695561 2706 6836607
SGTC_2837 9008476 45.46 µM -0.151997369279085 0.489202804290013 no 1725 0.439594505277637 2872 2992805
SGTC_254 nsc-64875 3.808 µM -0.152093030971944 0.489165255721839 no 1726 0.439556780371005 2821 56993
SGTC_2376 9072922 81.32 µM -0.152241732874358 0.489106888311608 no 1727 0.43949813974946 2800 17087968
SGTC_1932 st074806 40.9 µM -0.152512645019769 0.489000552408904 no 1728 0.439391308910239 2920 17251235
SGTC_2514 salinomycin 42.74 µM -0.152729916164122 0.488915271735084 no 1729 0.439305633922561 2819 23682228 A polyether potassium ionophore.
SGTC_1015 4130-4525 82 µM -0.15305120600776 0.48878916381409 no 1730 0.439178947191305 2700 1363237
SGTC_1700 st030840 7.9285 µM -0.153264061689777 0.488705617477338 no 1731 0.43909502020406 2793 5499307
SGTC_142 0335-0849 62.6745 µM -0.153758701760704 0.488511472050668 no 1732 0.438899998870915 2702 3889043 YPR107C YTH1
SGTC_1739 st037196 92.5 µM -0.153961403792383 0.48843191261531 no 1733 0.438820083989679 2770 612214
SGTC_2988 9073640 71.4286 µM -0.154381384274881 0.488267074048574 no 1734 0.4386545154427 2845 9102229
SGTC_464 bw-b 70c 158 µM -0.155515658873401 0.487821891553627 no 1735 0.438207405063417 2821 5353454
SGTC_2738 aclarubicin 5.55 µM -0.156241142492983 0.487537160128575 no 1736 0.437921473955196 2765 451415 Aclarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YOR116C RPO31
SGTC_2669 eugenol 100 µM -0.157940830389379 0.486870106713678 no 1737 0.43725171191647 2685 3314 Eugenol is a member of the phenylpropanoids class of chemical compounds; antifungal activity of unknown mechanism.
SGTC_3226 9131256 49.47 µM -0.158275531523391 0.486738755377272 no 1738 0.437119844056527 2672 17178073
SGTC_2673 kobusone 100 µM -0.15827715390218 0.486738118688502 no 1739 0.437119204877549 2693 6710676 An epoxy ketone and protein crosslinker.
SGTC_769 0302-0231 76 µM -0.158534437451328 0.486637150374678 no 1740 0.437017843305359 2762 571869 YER009W NTF2
SGTC_632 0781-2353 4.65 µM -0.158731880152807 0.486559666573865 no 1741 0.436940059935849 2771 6811515 YHR007C ERG11
SGTC_1874 staurosporine 7.6 µM -0.159178066598003 0.48638456842387 no 1742 0.436764291922403 2803 46864193 The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. YPR165W RHO1
SGTC_2768 sulfasalazine 50.2 µM -0.15924661557905 0.486357667794136 no 1743 0.436737289253123 2724 5384001 An antioxidant and salicylic acid derivative.
SGTC_213 1246-0773 967 nM -0.16052635058279 0.485855473791681 no 1744 0.436233233005779 2722 6251622
SGTC_2161 5662504 8.5105 µM -0.162539153025303 0.485065654933167 no 1745 0.43544064926447 2723 2859334
SGTC_2557 derrustone 83.84 µM -0.164958806677612 0.484116266456374 no 1746 0.434488202652299 2799 629853 An antioxidant.
SGTC_1574 spiramycin 23.7 µM -0.166765163746044 0.483407572768982 no 1747 0.433777415044296 2672 6419898 An antibiotic and protein synthesis inhibitor.
SGTC_3312 9133330 71.43 µM -0.166901530422199 0.483354073706711 no 1748 0.433723764469166 2850 17617324
SGTC_2320 7373003 200 µM -0.168111900945694 0.482879237159149 no 1749 0.433247623498596 2755 5415828
SGTC_2260 7964312 200 µM -0.168553763888524 0.482705897351445 no 1750 0.433073825579887 2909 231951
SGTC_2629 bisabolol 100 µM -0.168593054902187 0.482690483913535 no 1751 0.433058371874548 2858 6097621 A monocyclic sesquiterpene alcohol; an anti-infammatory and apoptosis inducer.
SGTC_1830 st055982 50.3 µM -0.169947360154989 0.482159220643339 no 1752 0.432525767405553 2690 455313 An antimicrobial agent.
SGTC_468 gf-109203x 121 µM -0.170076725537921 0.482108475176924 no 1753 0.43247489858133 2798 2396 A protein kinase C inhibitor.
SGTC_881 0833-0569 170 µM -0.170218351764597 0.482052920547362 no 1754 0.432419209853461 2721 5418700
SGTC_2634 4'-methoxyflavone 100 µM -0.170613724866263 0.481897832432569 no 1755 0.432263752641786 2767 77793 From seeds of Psoralea corylifolia (Fabaceae)
SGTC_91 0417-1751 58.384 µM -0.170676191545782 0.481873329651064 no 1756 0.43223919225375 2673 6795624
SGTC_2422 chlorphenesin carbamate 384.24 µM -0.170738978822738 0.481848701183055 no 1757 0.432214506078425 2706 2724 A muscle relaxant with antifungal properties.
SGTC_1005 4092-0690 4.4 µM -0.171522909387741 0.481541208300507 no 1758 0.431906309138706 2753 1529343
SGTC_317 4495-0002 170 µM -0.171584539584926 0.481517034624038 no 1759 0.431882081402747 2749 15991618
SGTC_899 1083-0020 478 µM -0.171700808130558 0.481471429921712 no 1760 0.431836375226949 2887 767123
SGTC_185 k048-0037 25.491 µM -0.172203825375055 0.481274131281154 no 1761 0.431638645296942 2705 6827589
SGTC_2715 st079500 56.4 µM -0.175158376348826 0.48011536082827 no 1762 0.430477594753436 2695 28246688
SGTC_1304 1165-0502 251 µM -0.176826321536565 0.479461268803584 no 1763 0.429822406619134 2755 767425
SGTC_3282 9108498 15.4605 µM -0.178161995156133 0.47893751832451 no 1764 0.429297877819956 2821 16459645
SGTC_1504 k297-0033 30 µM -0.178182565976029 0.478929452282107 no 1765 0.429289800482078 2683 4388117
SGTC_2806 7952793 58.44 µM -0.178200112280422 0.478922572191975 no 1766 0.429282910773815 2858 2972490
SGTC_916 4466-0038 42 nM -0.179236071606463 0.478516372868185 no 1767 0.428876170633038 2817 5722064 YGL116W CDC20
SGTC_1138 3761-0006 1.03 µM -0.180627255984717 0.477970925092824 no 1768 0.428330080292482 2702 12061087
SGTC_1513 0337-0559 19 µM -0.181458523052691 0.477645026186408 no 1769 0.428003843230958 2743 775073
SGTC_1518 st038567 90.8 µM -0.181533967830282 0.47761544873882 no 1770 0.427974236788478 2703 77966
SGTC_1615 st002656 86.5 µM -0.182098769457766 0.477394027260294 no 1771 0.427752607209372 2695 1584458
SGTC_3227 9130768 49.47 µM -0.182347647451865 0.477296460819304 no 1772 0.42765495408931 2746 17720899
SGTC_487 nimodipine 119 µM -0.182465502974315 0.477250258961074 no 1773 0.42760871225582 2796 4497 L-type voltage-gated calcium channels inhibitor
SGTC_2617 dihydrotanshinone i 20.83 µM -0.183517981508011 0.476837678739948 no 1774 0.427195805579074 2741 5316743 Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with a mouse xenograft model. YDR047W HEM12
SGTC_3139 9095020 49.47 µM -0.187841289546599 0.475143171763027 no 1775 0.42550053373116 2683 25236292
SGTC_1744 st037937 38.9 µM -0.188389611412303 0.474928290217842 no 1776 0.425285621395458 2909 1016152
SGTC_2932 9016711 44.54 µM -0.188432837860183 0.474911350538988 no 1777 0.425268679923137 2821 7117328
SGTC_2425 5628681 7.85 µM -0.18881132164907 0.474763031390153 no 1778 0.425120349027623 2831 5714958
SGTC_2958 9077254 16.72 µM -0.191256155723385 0.473805041942261 no 1779 0.42416245480971 2924 16457351
SGTC_2973 9094665 17.96 µM -0.192024990392125 0.473503811028028 no 1780 0.423861315090731 2979 25237061 YIL048W NEO1
SGTC_599 1935-0052 86.5 µM -0.193807379068962 0.472805526251995 no 1781 0.423163354452373 2752 9557311
SGTC_3045 9092950 49.47 µM -0.194559577460817 0.472510863128881 no 1782 0.422868875379531 2794 44120432
SGTC_2500 5-alpha-androstan-3,17-dione 61.44 µM -0.195388831163052 0.472186032113782 no 1783 0.422544279775769 2993 6710655
SGTC_2769 toremifene 3.73 µM -0.195895978573195 0.471987384028841 no 1784 0.422345792461064 2933 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_2781 5567276 71.43 µM -0.196789171791319 0.471637539958726 no 1785 0.421996262543667 2921 2853274
SGTC_2746 daunorubicin 9.88 µM -0.197281703344701 0.471444635563147 no 1786 0.421803548297568 2726 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_3057 9095946 49.47 µM -0.199172501062913 0.47070415031648 no 1787 0.421063904715884 2731 24540043
SGTC_1391 3442-0225 151 µM -0.199298563600119 0.470654784542454 no 1788 0.421014601358573 2759 5227075
SGTC_957 1187-1561 14.1 µM -0.199800305253693 0.470458308243524 no 1789 0.420818381291367 2737 1538454
SGTC_3245 9134821 49.47 µM -0.200718375844886 0.470098820941204 no 1790 0.420459395138718 2758 17014901
SGTC_174 3553-0389 74.3 µM -0.201455270639232 0.469810293946005 no 1791 0.420171300617971 2915 738071
SGTC_3109 9122853 49.47 µM -0.20155260925948 0.469772182740862 no 1792 0.420133248552069 2817 1234709
SGTC_553 k007-0256 45.7 µM -0.203447446532284 0.469030348505192 no 1793 0.419392659093576 2806 6287000
SGTC_603 3794-0023 45.9 µM -0.204752820108835 0.468519353384848 no 1794 0.418882625032001 2853 3802260
SGTC_746 1095-0025 46.6 µM -0.205827968380645 0.468098520038799 no 1795 0.418462646663664 2945 6749286
SGTC_539 4859-0462 2.54 µM -0.206593569949247 0.467798870823196 no 1796 0.418163641186427 2947 46499474 YNL221C | YBR257W POP1 | POP4
SGTC_2185 6113692 200 µM -0.207800463331215 0.467326541280136 no 1797 0.417692385412539 2896 874150
SGTC_2985 9022375 71.43 µM -0.207832779238637 0.467313894762731 no 1798 0.417679768638626 2968 4939335
SGTC_3335 9143315 29.6265 µM -0.209377705957363 0.466709341376956 no 1799 0.41707669756589 2827 4899691
SGTC_2899 9053889 58.44 µM -0.210228652335004 0.466376385792113 no 1800 0.416744608944049 2828 6470052
SGTC_2637 3-alpha-acetoxydihydrodeoxygedunin 100 µM -0.210954083998133 0.46609255977566 no 1801 0.416461550339686 2795 6708514
SGTC_304 1310-0298 97 µM -0.211226030144065 0.465986164953062 no 1802 0.416355449918899 2779 1550234
SGTC_222 nsc-310342 10.666 µM -0.211294723742065 0.465959290004558 no 1803 0.416328649915877 2759 432556
SGTC_1774 st048371 48.465 µM -0.212825932614183 0.465360276743432 no 1804 0.415731367895966 2791 4242727
SGTC_1834 st055981 52.8 µM -0.21342320927676 0.46512664161845 no 1805 0.41549843955921 2939 471719 YDL150W RPC53
SGTC_2582 agaric acid 100 µM -0.213425803743901 0.465125626773797 no 1806 0.415497427823266 2892 12629 Agaric acid is an inducer of mitochondrial permeability transition (MPT), and is used to study the MPT process at the level of the ADP and ATP exchange via the adenine nucleotide carrier/translocase.
SGTC_972 1319-0219 195 µM -0.214193309845006 0.464825421178826 no 1807 0.415198156496635 2855 23903702
SGTC_1967 st070177 51.4 µM -0.214950731843581 0.46452917954941 no 1808 0.414902865462078 2961 5729214
SGTC_67 0335-0847 266 µM -0.215303790437783 0.464391098569008 no 1809 0.414765237292544 3162 4552207 YOR254C SEC63
SGTC_3098 9119039 49.47 µM -0.21532634837289 0.464382276321233 no 1810 0.41475644418597 2767 17161528
SGTC_2121 5257820 149.641 µM -0.215770232651803 0.464208679908835 no 1811 0.414583426326763 2926 791256
SGTC_2145 5634607 200 µM -0.216178776171311 0.464048910752143 no 1812 0.414424198283282 2775 308662
SGTC_1880 MG-132 525 µM -0.21630229520407 0.464000607291299 no 1813 0.414376060049757 2890 462382 MG-132 [Z-Leu-Leu-Leu-CHO] is a proteasome inhibitor, often used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. YDR086C SSS1
SGTC_820 1582-0060 59.9 µM -0.216480400670834 0.463930958146269 no 1814 0.41430665048057 2841 3848840
SGTC_584 0986-0246 15.4 µM -0.21689115411976 0.463770334916405 no 1815 0.414146585757829 2773 53315 YDR232W HEM1
SGTC_196 k015-0023 18.111 µM -0.217546500817565 0.463514076869324 no 1816 0.413891236091731 2777 5211998
SGTC_920 mycophenolic acid 780.421 nM -0.218164840564723 0.463272303405374 no 1817 0.413650339210292 2829 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_1630 st005209 31.3 µM -0.219937125097214 0.462579408101772 no 1818 0.412960061244587 2781 3367314
SGTC_27 0485-0001 32.618 µM -0.220867365353915 0.462215765127571 no 1819 0.412597854288283 2759 2054479
SGTC_387 norethindrone acetate 66.7 µM -0.221548103064039 0.461949675926241 no 1820 0.412332843086612 2839 541197
SGTC_1938 st074717 56.4 µM -0.221588224406721 0.461933993681966 no 1821 0.412317225093248 2758 17250979
SGTC_1596 piperlongumine 63 µM -0.221936869995406 0.461797720943994 no 1822 0.412181514035623 2960 637858 Piperlongumine selectively kills cancer cells without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1), increasing the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells.
SGTC_2011 4012611 177 µM -0.223009269054782 0.461378587774435 no 1823 0.411764146248262 2795 2049887
SGTC_2859 9028643 45.46 µM -0.223219819990398 0.461296301713436 no 1824 0.411682213479869 2897 17151580
SGTC_2676 harmalol 100 µM -0.223512328572321 0.461181988282419 no 1825 0.411568394502558 2862 5459187 A monoamine oxidase inhibitor
SGTC_1237 0330-0133 46.1 µM -0.223796319567208 0.461071006624303 no 1826 0.411457896950788 2799 X1237 YHR072W ERG7
SGTC_675 1309-0189 238 µM -0.224268515573253 0.460886482504015 no 1827 0.411274186595306 2841 4246530
SGTC_933 2914-0560 114 µM -0.224659813133144 0.460733578148844 no 1828 0.411121964946655 3010 463887
SGTC_1871 st057448 67.3 µM -0.226586423765852 0.45998081633435 no 1829 0.41037267500515 2990 691747
SGTC_3185 9108267 49.47 µM -0.229411715106053 0.45887718374377 no 1830 0.409274465806202 2882 4910486
SGTC_2975 9084847 53.72 µM -0.230307282238774 0.458527417568674 no 1831 0.408926501145116 2915 27211724
SGTC_1212 0520-0165 585 µM -0.230762379051669 0.45834969055924 no 1832 0.408749704800195 3228 5403258
SGTC_2379 9035213 200 µM -0.231911214510805 0.457901077885728 no 1833 0.408303487023219 2953 646551
SGTC_2265 7929201 200 µM -0.231939568204703 0.457890006630931 no 1834 0.408292475700394 2784 1265108
SGTC_3339 9145883 14.936 µM -0.232711102520136 0.457588758524473 no 1835 0.407992873659923 2968 2030670
SGTC_2177 5811945 192 µM -0.233381017507052 0.457327207774615 no 1836 0.407732776036512 2974 5343475
SGTC_2167 5876490 200 µM -0.234511704684595 0.456885802577678 no 1837 0.407293873746147 3050 686534
SGTC_1948 st076329 66.6 µM -0.236133689778224 0.456252694238097 no 1838 0.406664466169877 2768 24208413
SGTC_527 4476-4215 268 µM -0.236468531057268 0.456122009645098 no 1839 0.406534561745802 2832 4418754
SGTC_1260 0700-1617 7.75 µM -0.238302242338205 0.455406418351853 no 1840 0.405823341153403 2938 2853078
SGTC_2216 7189485 200 µM -0.238322898193463 0.455398358387636 no 1841 0.405815331368934 2931 731273
SGTC_1475 4092-1048 11.7 µM -0.238431397679789 0.455356021929642 no 1842 0.405773258837293 2905 2881759
SGTC_1081 sertraline 6 µM -0.239168231315377 0.455068523164466 no 1843 0.405487567809467 2940 63009 A selective serotonin uptake inhibitor that is used in the treatment of depression. Also called zoloft. YGL099W LSG1
SGTC_205 1486-1330 71.903 µM -0.240962302829473 0.454368608564166 no 1844 0.404792166864164 2819 4118834
SGTC_1762 st045503 25.4615 µM -0.242349755434036 0.45382742374884 no 1845 0.404254581664079 2918 4645554
SGTC_1777 st045864 34.765 µM -0.242413855050566 0.45380242334493 no 1846 0.404229749856913 2833 4691462
SGTC_1034 k072-0165 12.7 µM -0.242843457543934 0.453634872690621 no 1847 0.404063334390005 3005 5835461
SGTC_1217 1183-1422 255 µM -0.243227898182894 0.453484942752493 no 1848 0.403914428025442 2969 2849664
SGTC_1713 st033146 12.748 µM -0.243711498525544 0.453296350440479 no 1849 0.403727133657758 2969 674619
SGTC_1775 st081588 35.1725 µM -0.244159644252017 0.453121593963885 no 1850 0.403553590270417 2848 1426443 YGL099W LSG1
SGTC_1749 st037932 54.2 µM -0.245622926066859 0.452551043917327 no 1851 0.402987070192048 2973 594497
SGTC_2215 7188065 200 µM -0.245631693578408 0.452547625659965 no 1852 0.402983676399305 2963 940217
SGTC_2083 5306046 65.942 µM -0.247198740721049 0.451936725629971 no 1853 0.402377209914033 2869 539837
SGTC_2062 5245942 200 µM -0.247437935979777 0.451843487362102 no 1854 0.40228465903982 2810 1376160
SGTC_515 4092-1064 102 µM -0.248282009876796 0.451514488770733 no 1855 0.401958108672135 3083 717353
SGTC_2753 fluvastatin 17.09 µM -0.248776798337179 0.451321648247979 no 1856 0.401766719607592 2925 446155 Fluvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YOR319W | YOR157C | YKL145W | YBR198C HSH49 | PUP1 | RPT1 | TAF5
SGTC_2739 tacrine 100.86 µM -0.248844837950276 0.451295131157193 no 1857 0.401740403054506 2944 1935 A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
SGTC_248 streptozotocin 5.23457 mM -0.249931902423539 0.450871498876983 no 1858 0.401320005702842 2927 5300 DNA alkylating agent.
SGTC_92 0063-0024 660.874 µM -0.250018705005547 0.450837674056991 no 1859 0.401286441704718 2779 3594437
SGTC_472 calcifediol 10 µM -0.250396273400874 0.450690549145928 no 1860 0.401140455621118 2913 5283731 A vitamin D metabolite.
SGTC_1083 didemethylchlorpromazine sulfoxide 707.394 nM -0.25167742547421 0.450191380580824 no 1861 0.40064520365168 3266 398788 A metabolite of chlorprazamine and quinoline alkaloid. Quinoline alkaloids readily oxidize, producing quinone and semiquinone derivatives that may lead to the formation of reactive oxygen species YPL252C | YPL251W YAH1 | YPL251W
SGTC_306 1672-3436 11.6 µM -0.253155088351641 0.449615744430156 no 1862 0.400074185282133 2940 6797378
SGTC_3217 9129673 49.47 µM -0.254284032120597 0.449176026145851 no 1863 0.399638067492604 3027 17248312
SGTC_1538 2',3',6-trimethoxyflavanone 63.6 µM -0.254494707961423 0.449093975791472 no 1864 0.399556695988277 2907 4213774
SGTC_2928 9011484 9.79 µM -0.255777650032134 0.448594364994716 no 1865 0.399061266331324 2984 2994751
SGTC_1044 1222-0021 1.78 µM -0.257466223819144 0.447936915093381 no 1866 0.398409443049416 2984 4306703
SGTC_1147 3809-1045 12.3 µM -0.258518532201542 0.447527268727722 no 1867 0.398003374137219 2870 325925
SGTC_1646 st011709 75.6 µM -0.258663054521611 0.447471012923871 no 1868 0.397947613910828 2960 5757843
SGTC_1798 st045719 60.953 µM -0.259268710301134 0.447235270861221 no 1869 0.39771395986319 2862 3980186
SGTC_118 0083-0097 135.343 µM -0.259493239038569 0.447147881285023 no 1870 0.397627348941406 2895 5207356
SGTC_1958 st076513 41.9 µM -0.26041080938427 0.446790777396044 no 1871 0.397273452916622 2845 732122 YGL099W LSG1
SGTC_2281 7943571 200 µM -0.260960335250408 0.446576931243136 no 1872 0.397061547756613 3059 1244024
SGTC_1276 0871-0068 94.2 µM -0.260966708138487 0.446574451346059 no 1873 0.397059090456477 2963 3414906
SGTC_2001 4023502 57.655 µM -0.261582251047052 0.446334933533189 no 1874 0.396821764644345 2989 108941 YCR052W RSC6
SGTC_1875 nocodazole 6 µM -0.261791719982584 0.446253430205126 no 1875 0.396741011502053 2915 4122 A microtubule depolymerizer. YJL014W CCT3
SGTC_2890 9046729 58.44 µM -0.263388817554264 0.445632082333394 no 1876 0.396125454355889 2898 903329
SGTC_2512 diallyl trisulfide 49.23 µM -0.263786931459228 0.445477217580408 no 1877 0.395972052600118 2876 16315 Antifungal agent Antilipemic agent Antioxidant Antiprotozoal agent Insecticide Platelet aggregation inhibitor Spermatocidal agent
SGTC_2129 girgensonine 121.053 µM -0.264644653518191 0.445143595351695 no 1878 0.395641608815734 2946 442638 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1400 3771-8998 51.5 µM -0.264764877136184 0.445096835899766 no 1879 0.395595297763037 2873 670767
SGTC_2429 5902844 64.44 µM -0.265118831523657 0.444959174266 no 1880 0.395458960399991 3045 1927790 YGL093W | YPR107C SPC105 | YTH1
SGTC_1500 4488-1866 171 µM -0.265119273179736 0.444959002499147 no 1881 0.395458790289378 3009 2900003
SGTC_2845 9003024 42.97 µM -0.266107836893825 0.444574560802276 no 1882 0.395078079789104 3107 2990173
SGTC_1350 1495-0454 146 µM -0.266971552443798 0.444238713861695 no 1883 0.394745532117345 3038 1069057
SGTC_2273 7815444 169.05 µM -0.267224926736588 0.444140199448563 no 1884 0.394647992508202 3064 2824616
SGTC_2066 5222451 176 µM -0.268641340687282 0.443589547537716 no 1885 0.394102848019328 2874 2281147
SGTC_541 4513-1321 94 µM -0.268764605820401 0.443541631526686 no 1886 0.39405541595742 2899 747515
SGTC_2869 9037858 32.47 µM -0.269253897626537 0.44335144062194 no 1887 0.393867153409355 2841 27187042
SGTC_414 piperonyl butoxide 100 µM -0.270169662305466 0.442995512041376 no 1888 0.393514865543113 2882 5794 A potent inhibitor of cytochrome P450.
SGTC_1645 Cervolide 78 µM -0.2723743782332 0.442138798346674 no 1889 0.392667085708322 2956 23173 A fragrance.
SGTC_1704 st028805 70.8 µM -0.272925089989022 0.441924843553758 no 1890 0.392455399705189 2937 2876101
SGTC_381 3461-2219 42.7 µM -0.274255588963999 0.441408006816169 no 1891 0.391944105646687 3010 2883159
SGTC_2998 9066762 71.4286 µM -0.276486404207111 0.440541663521647 no 1892 0.39108725034646 3061 4945196
SGTC_1629 st005085 44.9 µM -0.278297651406233 0.439838469735329 no 1893 0.390391939421663 2894 24207091
SGTC_2356 9061756 188.97 µM -0.278335962916016 0.439823597818323 no 1894 0.390377235978256 2969 20104043
SGTC_2034 5197015 53.07 µM -0.278476624633751 0.439768995911491 no 1895 0.390323253243074 3052 780676
SGTC_1178 0988-0033 191 µM -0.278522588333753 0.439751154022597 no 1896 0.390305613889474 3039 5392207
SGTC_2113 5491891 107.031 µM -0.279191567166882 0.439491488057318 no 1897 0.39004890743419 2907 789979
SGTC_2160 5660466 132.927 µM -0.279805477988271 0.43925321979398 no 1898 0.38981337434356 2928 2859134
SGTC_1264 0783-0040 158 µM -0.280780927637775 0.438874678029833 no 1899 0.389439216468505 2854 2855798
SGTC_371 0195-0006 7.36 µM -0.281551832922749 0.438575553120953 no 1900 0.389143589122098 2816 3928593
SGTC_3050 9093513 49.47 µM -0.286428510159281 0.436684135778445 no 1901 0.387274970522983 2917 25236664
SGTC_137 0438-0332 85.389 µM -0.28794455373073 0.436096431608728 no 1902 0.386694590771217 2973 2063393 YER012W | YPR107C PRE1 | YTH1
SGTC_190 3970-0790 3.722 µM -0.289628686383857 0.435443732054781 no 1903 0.38605015931371 2995 2832352
SGTC_46 0329-0187a 2.197 µM -0.290207011172941 0.435219637961082 no 1904 0.38582893638856 3009 46494817
SGTC_1071 trifluoperazine 6.31 µM -0.291251954760461 0.434814787340706 no 1905 0.385429314912702 3067 2913535 Phenothiazine antipsychotic; D2 dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.
SGTC_1339 1486-1321 22.7 µM -0.292211876212749 0.434442937718205 no 1906 0.38506231590766 2943 3469382
SGTC_1735 st034310 56.75 µM -0.29483395695587 0.433427505547831 no 1907 0.38406036246911 3107 871153
SGTC_1132 3456-3614 2.5 µM -0.29591605571853 0.43300857751179 no 1908 0.383647094607442 3183 3125502
SGTC_909 3448-9333 149 µM -0.296033432832753 0.432963140184146 no 1909 0.383602274678115 2897 3344074
SGTC_1721 st082152 9.2685 µM -0.296190004265808 0.432902531899402 no 1910 0.383542490996679 2864 5296051
SGTC_2002 4023503 131 µM -0.296412758125163 0.432816307336409 no 1911 0.383457441652925 3049 4736863 YCR052W RSC6
SGTC_1547 harmine 94.2 µM -0.296501487525326 0.432781962452828 no 1912 0.383423565566705 2954 5280953 A monoamine oxidase inhibitor YHR072W ERG7
SGTC_967 1306-0166 352 µM -0.29706691238067 0.432563112877813 no 1913 0.383207712392196 3089 4437607
SGTC_2283 7944793 200 µM -0.297457218889875 0.432412055506525 no 1914 0.383058732485172 3012 2970533
SGTC_359 0081-0058 15.9 µM -0.299231365130363 0.431725545955491 no 1915 0.382381759557156 3322 3494159
SGTC_1604 st002052 72.4 µM -0.300616511272532 0.431189703989526 no 1916 0.381853469681196 3062 6254834 YHR062C RPP1
SGTC_609 0986-0026 86.3 µM -0.302385548951659 0.430505538337142 no 1917 0.381179084855298 2953 2848610
SGTC_1362 1611-0397 101 µM -0.302563593269286 0.430436692187629 no 1918 0.381111231521002 2948 27816
SGTC_1641 st009299 47.1 µM -0.302825859494479 0.43033528297569 no 1919 0.381011287570882 2978 4046054
SGTC_2678 equilin 100 µM -0.303424958185844 0.430103649629927 no 1920 0.380783013883751 3042 3247 Equilin is an estrone commonly used hormone replacement therapy
SGTC_219 mitoxanthrone 164.414 µM -0.303792894000563 0.429961404177774 no 1921 0.380642840406591 2985 4212 Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. YMR168C CEP3
SGTC_2608 thymoquinone 42.66 µM -0.304455553028073 0.429705240498138 no 1922 0.380390424979825 3018 10281 A benzoquinone with antoxidant properties and demonstrated potential to act as a histone deacetylase inhibitor (HDAC).
SGTC_585 0kpi-0023 191 µM -0.304524247963083 0.429678686831723 no 1923 0.380364261098425 3071 64601
SGTC_257 daunorubicin 18.5 µM -0.306328769154834 0.428981272932616 no 1924 0.379677168386098 3047 30323 Daunorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction. YIL143C SSL2
SGTC_848 0368-0089 85.6 µM -0.306523052552669 0.428906199189335 no 1925 0.379603215297624 3064 762535
SGTC_1192 1488-0095 21.4 µM -0.306534930169663 0.42890160960023 no 1926 0.37959869427976 3027 915875
SGTC_44 0929-0055 61.211 µM -0.308472565094408 0.42815302389848 no 1927 0.378861386478985 2928 1379590
SGTC_2751 anetholtrithion 17.25 µM -0.308879549166639 0.427995822466929 no 1928 0.378706577021131 3073 2194 A chloretic substance that stimulates the liver to produce bile.
SGTC_1810 st050138 53 µM -0.308912188265531 0.427983215802184 no 1929 0.37869416253459 3066 3444541
SGTC_2710 st078562 53.7235 µM -0.30906526859557 0.427924090383785 no 1930 0.378635939138694 2907 17250908
SGTC_744 1594-0068 283 µM -0.309491484016331 0.427759478383182 no 1931 0.378473844589186 2973 668392
SGTC_1230 0170-0365 3.77 µM -0.310075682287466 0.427533871019953 no 1932 0.378251702115292 3070 4018932 YCR093W | YMR134W | YIL048W | YNL267W CDC39 | ERG29 | NEO1 | PIK1
SGTC_1376 2910-0861 41.3 µM -0.310604545667942 0.42732965347496 no 1933 0.37805063553436 2935 1112859
SGTC_1977 st070720 65.3 µM -0.312056448431576 0.426769109856728 no 1934 0.377498812020313 3054 682188
SGTC_1793 st048256 72.231 µM -0.312751191177379 0.426500939161456 no 1935 0.377234850060156 2928 672022
SGTC_526 4469-0568 170 µM -0.314491777837387 0.425829222178758 no 1936 0.37657378012817 2952 2901964
SGTC_3201 9113999 49.47 µM -0.314905083177153 0.425669753349082 no 1937 0.376416861002334 3142 16649224
SGTC_17 0960-0276 49.807 µM -0.315295695784494 0.425519051407406 no 1938 0.376268576368535 2975 6821114
SGTC_847 0342-0274 5.54 µM -0.315573393710715 0.425411919605508 no 1939 0.376163167590629 3084 18097
SGTC_663 1486-0733 13.9 µM -0.31614554822659 0.425191208124062 no 1940 0.375946017898898 2963 722445 YPR165W RHO1
SGTC_821 1114-0266 29.2 µM -0.316169039320771 0.425182146816934 no 1941 0.375937103167445 3033 3123235
SGTC_1346 1488-2224 62.4 µM -0.316444546751566 0.425075877262267 no 1942 0.375832554668283 3072 3722427
SGTC_961 1252-1571 372 µM -0.317409485226883 0.424703721266063 no 1943 0.375466455441413 3145 6813498
SGTC_1554 st069299 38.7 µM -0.319525093546554 0.423888011983308 no 1944 0.374664182991142 3045 24207999
SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 67.5 µM -0.319916757503663 0.423737034847564 no 1945 0.37451571714406 3007 688788
SGTC_2638 epoxomicin 18 µM -0.320515889211441 0.423506105497015 no 1946 0.374288643665346 3071 9915668 A protesome inhibitor.
SGTC_958 1222-0007 33 µM -0.320899103049544 0.42335841331013 no 1947 0.374143426840442 3139 7312461
SGTC_1058 3448-5425 97.3 µM -0.321215980658257 0.423236295511022 no 1948 0.374023361259976 2963 7279705
SGTC_1832 st054113 55 µM -0.321919637705526 0.422965147639985 no 1949 0.373756787864982 3088 1251267
SGTC_859 0439-0102 54.6 µM -0.322271449071092 0.422829593990342 no 1950 0.373623530300396 3110 610143
SGTC_1699 st031318 29.054 µM -0.322667509626442 0.42267700196947 no 1951 0.373473530300185 3084 5340658
SGTC_548 1436-0017 110 µM -0.322836352539042 0.42261195463158 no 1952 0.37340959025613 3120 9677137
SGTC_1946 st076057 65.1 µM -0.323564243518778 0.42233155619971 no 1953 0.37313398116795 2945 953009
SGTC_491 tetrandrine 80.3 µM -0.3240590608173 0.422140964960176 no 1954 0.372946660291131 3064 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_3033 9090887 49.47 µM -0.324091991060331 0.42212828170125 no 1955 0.372934195094767 2970 19325384
SGTC_796 1234-0020 70.7 µM -0.324214334307353 0.422081161253904 no 1956 0.372887885256679 2969 46495034
SGTC_326 k292-0812 17.5 µM -0.325436850578104 0.421610371018972 no 1957 0.372425234664342 3062 3579357
SGTC_2935 9038016 29.96 µM -0.32605881702171 0.421370895091901 no 1958 0.372189927493903 3148 6463195
SGTC_1495 4469-0029 237 µM -0.32662246203792 0.421153899798472 no 1959 0.371976726149539 2965 793680
SGTC_2616 abietic acid 100 µM -0.327366705687376 0.420867413303864 no 1960 0.371695272667309 3141 6708678 Abietic acid is an inhibitor of 5α-reductase.
SGTC_1635 st007035 42.4 µM -0.328025869021399 0.420613712306641 no 1961 0.371446051586473 3057 3716403
SGTC_1737 st035557 69.7 µM -0.330464661394162 0.419675349165437 no 1962 0.370524445135122 2977 5716916
SGTC_1122 capsaicin 818.572 nM -0.332064792543054 0.419059921620734 no 1963 0.369920167299406 3120 1548943 An isomer of capsaicen, an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel.
SGTC_696 1560-0013 611 µM -0.33278238030534 0.418783993911851 no 1964 0.369649279696822 3194 1650269
SGTC_2580 diallyl disulphide 81.36 µM -0.333600061224112 0.418469626966022 no 1965 0.369340686025231 2968 16590 Diallyl disulfide is an efficient agent for detoxication of the cells. It significantly increases the production of the enzyme glutathione S-transferase (GST), which binds electrophilic toxins in the cell.
SGTC_1162 k048-0130 20.1 µM -0.334185751212868 0.418244483625542 no 1966 0.369119697707793 2992 6797406
SGTC_2285 7945142 200 µM -0.33569387888108 0.417664872224654 no 1967 0.368550861093004 3105 2970608
SGTC_2138 5575593 77.673 µM -0.335770815131963 0.417635308471476 no 1968 0.368521849934543 3008 762213
SGTC_3152 9099253 49.47 µM -0.335900888428526 0.417585327177603 no 1969 0.368472803538027 3057 25236131
SGTC_276 colchicine 750 µM -0.337650247509466 0.416913257162207 no 1970 0.367813385805276 3136 2833 A microtubule depolymerizer.
SGTC_129 0088-0017 176.636 µM -0.338039587923607 0.416763713040426 no 1971 0.367666677554137 3134 182446
SGTC_753 1322-0200 289 µM -0.340166243382501 0.41594708616032 no 1972 0.366865668921878 3130 5403907
SGTC_3164 9100705 49.47 µM -0.340715392415878 0.415736274001827 no 1973 0.366658924914533 3135 17174235
SGTC_761 k216-0224 480 µM -0.341529483739117 0.415423798102336 no 1974 0.36635250643926 3191 1340404
SGTC_2313 7726885 200 µM -0.341660828678982 0.415373388458659 no 1975 0.36630307706678 3091 726423
SGTC_1529 apigenin 74 µM -0.342241349694514 0.415150603592522 no 1976 0.366084634706225 3240 5280443 Natural flavone that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase.
SGTC_358 0075-0058 9.45 µM -0.343676740652943 0.414599865028997 no 1977 0.365544702561527 3168 1069125
SGTC_1199 1638-0010 4.46 µM -0.343986559313596 0.414481014115711 no 1978 0.365428197056867 3001 3111136
SGTC_59 0330-0160 1.33 µM -0.344280845851949 0.414368128799068 no 1979 0.365317543813951 3045 4293482
SGTC_987 1497-1013 404 µM -0.34456192407689 0.414260316660606 no 1980 0.365211867431354 3029 1676435
SGTC_2831 7999036 19.48 µM -0.34498722093468 0.414097199397908 no 1981 0.365051988936233 3246 2988270
SGTC_1883 5-benzylidenerhodanine 20 µM -0.345172050354628 0.414026315015096 no 1982 0.364982514779805 3118 1273210
SGTC_640 3381-0960 37.1 µM -0.345805733154804 0.413783311050488 no 1983 0.364744358123012 3083 1745025
SGTC_3083 9117465 49.47 µM -0.347102437888974 0.413286155172176 no 1984 0.364257181031813 3100 16420915
SGTC_1317 1273-0028 910 nM -0.347404475266328 0.413170374139718 no 1985 0.364143735848064 3020 5917803 YLR359W | YHR072W ADE13 | ERG7
SGTC_902 1120-0002 2.07 µM -0.348002278907149 0.412941238275406 no 1986 0.36391923601251 3011 3280475
SGTC_596 1155-0152 116 µM -0.348900810450028 0.412596890360165 no 1987 0.363581888359637 3044 280313
SGTC_1208 2323-2347 50.3 µM -0.349823922523551 0.412243192390905 no 1988 0.363235422233322 3181 5412760
SGTC_1185 1319-0113 81.3 µM -0.351346366822106 0.41166001117592 no 1989 0.362664256839779 3132 4672763
SGTC_932 2857-0803 154 µM -0.353902500980899 0.410681308365322 no 1990 0.361705976337849 3250 674898
SGTC_3351 9150312 21.596 µM -0.354925403355067 0.410289810822224 no 1991 0.361322738365327 3103 4904905
SGTC_2834 9001755 58.44 µM -0.354940426299927 0.410284061724533 no 1992 0.361317110943123 3049 2989575
SGTC_651 3253-0966 34.4 µM -0.357035810684502 0.409482373121474 no 1993 0.360532498549753 3045 781462
SGTC_303 1348-1668 34.2 µM -0.357603443304228 0.409265263352206 no 1994 0.360320050558711 3071 5380509
SGTC_704 1310-0270 142 µM -0.357653022141119 0.409246301615523 no 1995 0.360301496722762 3090 5718033
SGTC_2663 amphotericin b 100 µM -0.359138871079561 0.408678128114392 no 1996 0.359745601892053 3072 16667679 Amphotericin b is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_1908 st060353 56.5 µM -0.35981847643755 0.408418317825499 no 1997 0.359491442584527 3253 4227716
SGTC_1042 0350-0096 82 µM -0.36095987436977 0.407982056785097 no 1998 0.359064721634333 3034 3122515
SGTC_2033 5192550 145 µM -0.361036463294918 0.407952787317159 no 1999 0.359036094525974 3063 182073
SGTC_2222 6885208 172.143 µM -0.363200893798927 0.407125834625038 no 2000 0.358227409998196 3076 609514
SGTC_2456 5770359 74.46 µM -0.363792926373111 0.406899711744715 no 2001 0.358006322595725 3202 3118787
SGTC_2337 9009472 200 µM -0.366716364370655 0.405783580506601 no 2002 0.356915299364293 3257 5742383
SGTC_3059 1327-0034 3 µM -0.366778548588236 0.405759847650129 no 2003 0.356892104964782 3046 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1608 st001473 40.5 µM -0.368704170348168 0.40502509822377 no 2004 0.35617411997287 3060 7292267
SGTC_3265 9137266 49.47 µM -0.368760067034622 0.405003775003331 no 2005 0.356153286001756 3128 17224265
SGTC_2057 5236571 38.335 µM -0.371437572978394 0.403982703326151 no 2006 0.35515582239571 3236 54684039 YBR257W POP4
SGTC_97 0535-0701 19.132 µM -0.371503165425351 0.403957697706609 no 2007 0.355131399356896 3080 2832013 YGL099W LSG1
SGTC_1210 3013-0140 750 nM -0.372023414075928 0.40375937872217 no 2008 0.354937708308276 3174 905973
SGTC_846 0335-0850 148 µM -0.373610583824741 0.403154502077022 no 2009 0.354347029264974 3131 6819598
SGTC_917 harmaline 728.087 nM -0.374094657017011 0.402970065909971 no 2010 0.354166946835699 3149 5280951 Harmaline is a fluorescent psychoactive indole alkaloid family; monoamine oxidase (MAOI) inhibitor. YHR072W ERG7
SGTC_2432 5630864 12.22 µM -0.374697549057768 0.402740388900059 no 2011 0.353942707627323 3185 5714970
SGTC_1375 2910-0797 186 µM -0.376217929621239 0.402161335792625 no 2012 0.353377443513367 3106 742508
SGTC_1389 3405-0187 19 µM -0.378439265541649 0.401315702615194 no 2013 0.352552151800639 3096 799890
SGTC_2250 alverine citrate 130 µM -0.378546276356965 0.401274976647937 no 2014 0.352512411611972 3088 21718 An antispasmotic used to treat irritable bowel syndrome. YIL048W NEO1
SGTC_3118 9124250 49.47 µM -0.381733095183905 0.400062636800484 no 2015 0.351329674663307 3097 1504786
SGTC_3197 9113331 49.47 µM -0.38300081557759 0.399580633483981 no 2016 0.350859579680057 3295 16610459 YLR208W | YDL195W SEC13 | SEC31
SGTC_2405 ticlatone 3.52 µM -0.383639025138963 0.399338035998029 no 2017 0.350623005677274 2894 6258 An FDA approved topical antifungal of unknown mechanism. YOR282W YOR282W
SGTC_726 3448-4391 34.2 µM -0.385283728470329 0.398713027454504 no 2018 0.350013607791689 3263 1356692
SGTC_1892 st058411 7.36 µM -0.385412010213102 0.39866428962842 no 2019 0.349966092863637 3190 3934738
SGTC_3338 9144300 39.5675 µM -0.385657355730793 0.398571080398369 no 2020 0.349875224631187 3128 4901274
SGTC_1445 4239-0156 97.7 µM -0.385731992341766 0.398542726346585 no 2021 0.34984758329262 3259 4008346
SGTC_2107 5363541 170.161 µM -0.385879003851611 0.398486879021899 no 2022 0.349793140558082 3187 244052
SGTC_1567 st069303 68.4 µM -0.386666157947985 0.398187887144971 no 2023 0.34950168654815 3167 5581319
SGTC_2135 5326629 150.42 µM -0.386938419994444 0.39808448528643 no 2024 0.349400898632159 3109 5020077
SGTC_2619 obliquin 87.91 µM -0.386938603512367 0.398084415590938 no 2025 0.349400830699759 3049 6708593 A bioactive alkalod. YER133W GLC7
SGTC_588 3970-1144 52.9 µM -0.387586671352977 0.397838316019261 no 2026 0.349160967044238 3175 1888707
SGTC_587 k089-0003 57 µM -0.389076969680855 0.397272539223479 no 2027 0.348609604710652 3154 9659696
SGTC_3027 9089541 49.47 µM -0.390829708166842 0.396607406242479 no 2028 0.347961557047471 3186 9943819
SGTC_2437 5741531 144.16 µM -0.390925473641159 0.39657107360119 no 2029 0.347926162030468 3262 2262990
SGTC_3000 9075062 71.4286 µM -0.391012465232282 0.396538070478133 no 2030 0.347894010998162 3091 17057871
SGTC_940 3232-1287 54.8 µM -0.391391478501167 0.396394287973982 no 2031 0.347753945075904 3185 1585493 YIL048W NEO1
SGTC_639 0833-0042 114 µM -0.391523668392536 0.39634414371914 no 2032 0.347705098640281 3111 5978911 YPR085C | YHR062C ASA1 | RPP1
SGTC_864 0469-0573 172 µM -0.39153331443877 0.396340484703133 no 2033 0.347701534359455 3109 689425
SGTC_3173 9105693 49.47 µM -0.391775435697116 0.396248644307528 no 2034 0.347612073289491 3260 17096658
SGTC_362 0310-0100 9.03 µM -0.392120885342002 0.396117619800707 no 2035 0.347484448239361 3214 790235
SGTC_799 1310-0557 151 µM -0.393479496744518 0.395602430322508 no 2036 0.346982682259072 3247 5354492
SGTC_1501 4491-0275 38.4 µM -0.393832606622226 0.395468559830492 no 2037 0.346852314653424 3204 5104718
SGTC_759 3486-0358 89.3 µM -0.393915085354475 0.395437292392395 no 2038 0.346821866247796 3276 875103
SGTC_1101 ebselen 5.29 µM -0.39402163541209 0.395396900584038 no 2039 0.346782532973644 3244 3194 A potent scavenger of hydrogen peroxide and hydroperoxides.
SGTC_2317 5986382 200 µM -0.39479388949231 0.395104182230593 no 2040 0.346497502437298 3153 877883
SGTC_1324 1418-0026 34.4 µM -0.394913141042781 0.395058985905331 no 2041 0.346453495734942 3188 1372513
SGTC_2726 cimetidine 79.27 µM -0.39507751786309 0.394996689421986 no 2042 0.34639284011532 3098 2756 A P450 inhibitor, histamine H2-receptor antagonist.
SGTC_2119 5528445 120.635 µM -0.396038626880357 0.394632496514358 no 2043 0.346038266429067 3243 791935
SGTC_107 0358-0022 2.6945 µM -0.39619452692205 0.394573430003142 no 2044 0.34598076427908 3168 521106 YGL093W | YPR107C SPC105 | YTH1
SGTC_2649 anisomycin 9.56 µM -0.398441703031953 0.393722302734266 no 2045 0.345152311290834 3168 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_157 1348-1695 65.819 µM -0.398521007012956 0.39369227526968 no 2046 0.345123088289953 3164 5380510
SGTC_1996 st072960 66.8 µM -0.398778474169474 0.393594792896363 no 2047 0.345028219685699 3223 1719405
SGTC_180 1486-1293 102.781 µM -0.399059712432745 0.393488317912835 no 2048 0.344924603301643 3275 4140536
SGTC_789 1309-1135 70.6 µM -0.400046831031238 0.393114664296091 no 2049 0.34456101208077 3104 3092424
SGTC_849 0386-0493 241 µM -0.400792998024097 0.392832283311258 no 2050 0.344286267238816 3088 726119
SGTC_3125 9127534 49.47 µM -0.400949921965995 0.392772903861217 no 2051 0.344228497000002 3174 1639235
SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 13.23 µM -0.40242756934968 0.392213890016082 no 2052 0.343684691871681 3112 5355888
SGTC_727 3032-0951 202 µM -0.403796257820877 0.39169629513525 no 2053 0.343181274276894 3144 3652836
SGTC_1298 1079-1278 263 µM -0.404901751263151 0.391278372194172 no 2054 0.342774865523932 3162 2840950
SGTC_454 lyso-paf C-16 6.67 µM -0.40590592465844 0.390898861231801 no 2055 0.34240586233519 3168 162126 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_1439 4092-1168 46 µM -0.407564656509272 0.390272198249377 no 2056 0.341796658316949 3187 2886240
SGTC_76 0433-0009 400.328 µM -0.408475345384626 0.389928264320252 no 2057 0.341462363731566 3197 2841569
SGTC_465 cgp-37157 41 µM -0.408915291885066 0.389762143442689 no 2058 0.341300913221263 3175 2688 A selective antagonist of mitochondrial Na+/Ca2+ exchange.
SGTC_802 4112-3352 742 µM -0.409616109213309 0.389497561069324 no 2059 0.341043788951328 3263 704594
SGTC_191 3914-0123 66.505 µM -0.410913414573329 0.389007919407129 no 2060 0.340568012828552 3088 3144412
SGTC_1805 st050013 60.3 µM -0.411703478671099 0.388709811987669 no 2061 0.340278387474662 3146 4037144
SGTC_1168 k815-0004 80.5 µM -0.41212428632 0.388551059347414 no 2062 0.340124164294416 3078 642433
SGTC_1688 st021091 57.6 µM -0.412177269697234 0.388531072315129 no 2063 0.34010474813727 3238 3656366
SGTC_1746 st038117 42 µM -0.413021806352397 0.388212525830503 no 2064 0.339795318602242 3202 2898218
SGTC_1498 4478-3555 97.6 µM -0.415871833637122 0.387138094701474 no 2065 0.338751895585211 3208 3437919
SGTC_2060 5238662 140 µM -0.416641755945433 0.386847989774553 no 2066 0.338470231211431 3215 790130
SGTC_1278 0874-0585 172 µM -0.417090068604445 0.386679095719626 no 2067 0.338306264446563 3200 766306
SGTC_1761 st044296 37 µM -0.417992503881976 0.386339183917712 no 2068 0.337976298964589 3101 1826700
SGTC_974 1326-0144 138 µM -0.419688729771489 0.385700518671309 no 2069 0.337356429674209 3164 5411856
SGTC_1709 st033179 39.1045 µM -0.423763689595668 0.3841674782222 no 2070 0.335869080753243 3145 573381
SGTC_2709 st078560 56 µM -0.423944450661999 0.384099515870301 no 2071 0.335803162761968 3305 17250903
SGTC_2685 mycophenolic acid 18.85 µM -0.42459483360281 0.383855015081718 no 2072 0.335566029939419 3166 446541 Mycophenolic acid is a potent reversible inhibitor of IMPDH (inosine monophosphate dehydrogenase), leading to a depletion of GMP and inhibition of de novo synthesis of purines. The resulting imbalance of nucleotide pools also results in inhibiting transcription-elongation.
SGTC_483 fpl-64176 144 µM -0.424685815329847 0.383820815678618 no 2073 0.335532862772164 3224 3423
SGTC_2027 5150920 200 µM -0.424719274952369 0.38380823866506 no 2074 0.335520665470467 3195 786715
SGTC_1985 st071382 65.5 µM -0.424835380227226 0.383764597232692 no 2075 0.335478342037703 3177 6123237
SGTC_606 k015-0008 38.6 µM -0.426400523246894 0.3831764383145 no 2076 0.334908010094419 3283 1970475
SGTC_1021 4476-0760 85.3 µM -0.427063546632477 0.382927364464091 no 2077 0.334666521655753 3146 746768
SGTC_2815 7968870 71.43 µM -0.427103141462525 0.382912491652352 no 2078 0.33465210246615 3147 2977326 YHR190W ERG9
SGTC_2920 7982904 15.77 µM -0.42912934503314 0.382151629658617 no 2079 0.333914548893055 3215 6456808
SGTC_2826 7992541 19.48 µM -0.429236222873842 0.382111508443971 no 2080 0.333875662319355 3196 2985066
SGTC_2520 obtusaquinone 4.71 µM -0.430045834522754 0.381807626879268 no 2081 0.33358115012045 3315 5967872
SGTC_1215 3852-0577 11.2 µM -0.430839484110567 0.381509807227163 no 2082 0.333292543945424 3310 2884876
SGTC_1008 4106-0037 6 µM -0.430866362292121 0.381499722326927 no 2083 0.333282771573539 3081 2905394
SGTC_1211 1056-0033 32.3 µM -0.431618321050702 0.381217614255396 no 2084 0.333009420227619 3284 6741922
SGTC_2659 sanguinarine 24.21 µM -0.431798172093874 0.381150149913725 no 2085 0.33294405408477 3134 13394149 Na+/K+-and Mg2++-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis.
SGTC_2023 5144124 124 µM -0.432363131490611 0.380938250187878 no 2086 0.332738754874863 3138 2830192
SGTC_2373 9071805 200 µM -0.432951849186305 0.380717477405566 no 2087 0.332524875544837 3312 10149009
SGTC_3148 9097893 49.47 µM -0.433018710266205 0.380692406540893 no 2088 0.332500588565599 3126 17174100
SGTC_2675 theaflavin digallate 100 µM -0.433368147263529 0.380561386483738 no 2089 0.332373668628698 3235 467320 Theaflavin digallate is an antioxidant natural phenol found in black tea, and a theaflavin derivative.
SGTC_1121 fusaric acid 630.51 nM -0.434041420816687 0.380308983791903 no 2090 0.332129181357515 3150 3442 Fusaric acid is a small molecule inhibitor of dopamine β-hydroxylase, an enzyme responsible for the conversion of dopamine to norepinephrine. May also act as an ETC uncoupler.
SGTC_2315 7733312 200 µM -0.43437601660614 0.380183566536257 no 2091 0.332007705436529 3135 726316
SGTC_2587 piperic acid 92.2 µM -0.43527179576187 0.379847861757635 no 2092 0.331682577280904 3185 5370536
SGTC_1135 dihydrocapsaicin 536.708 nM -0.435533268218947 0.379749888643189 no 2093 0.331587698248856 3119 107982 A Capsaicinoid.
SGTC_1455 4262-0120 131 µM -0.435774837642392 0.37965938000813 no 2094 0.331500050919861 3337 1529587
SGTC_652 0437-0092 114 µM -0.437571019106491 0.378986613113306 no 2095 0.330848641719653 3208 3091274
SGTC_2419 paclitaxel 166.5 µM -0.438377860800255 0.378684526500314 no 2096 0.330556196278724 3186 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3117 9124945 49.47 µM -0.438808738579114 0.378523233488262 no 2097 0.330400063952388 3127 17592065
SGTC_1868 st057644 42.7 µM -0.439029247337831 0.378440697331991 no 2098 0.330320172094792 3131 688665
SGTC_3010 9080089 71.4286 µM -0.439248955606054 0.37835846631354 no 2099 0.330240577952346 3261 17027233
SGTC_889 0919-1524 82.7 µM -0.440092550537086 0.378042782160483 no 2100 0.329935038565186 3244 3905452
SGTC_2147 5545932 89.7195 µM -0.440648641072684 0.377834730384484 no 2101 0.329733691635128 3227 797404
SGTC_170 4197-0004 226 µM -0.441347825840942 0.377573192632289 no 2102 0.329480603757959 3286 218692
SGTC_2272 7805186 180 µM -0.442922353608579 0.376984428877504 no 2103 0.328910949084535 3302 2956062 YPR165W RHO1
SGTC_444 curcumin 90.4 µM -0.443773194762624 0.37666639243359 no 2104 0.328603285086729 3300 6610332 A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties.
SGTC_923 1900-2434 73.3 µM -0.445235752317438 0.376119897809327 no 2105 0.328074696075331 3167 5910570
SGTC_956 1185-0240 191 µM -0.445457544754387 0.37603704520585 no 2106 0.327994567172584 3173 1416193
SGTC_2467 5474540 200 µM -0.446588941058064 0.375614490702576 no 2107 0.32758594094332 3157 5413519
SGTC_3063 1327-0034 4 µM -0.446848907236096 0.375517419448897 no 2108 0.327492078146847 3259 15998580 YGL093W | YPR107C SPC105 | YTH1
SGTC_1117 retinoic acid 1.10837 µM -0.447126778350931 0.375413671212908 no 2109 0.327391762690035 3336 444795 A transcription inhibitor binds retinoic acid receptor (RAR), which is bound to DNA as a heterodimer with the retinoid X receptor (RXR).
SGTC_2941 9056145 11.23 µM -0.447782115443106 0.375169024881421 no 2110 0.327155225970247 3241 2119517
SGTC_2030 5175110 200 µM -0.449299584916546 0.374602725576982 no 2111 0.3266077785892 3302 2831986
SGTC_1006 4099-6547 255 µM -0.449631991796384 0.374478711831486 no 2112 0.326487908151233 3306 3146833
SGTC_2665 lovastatin 100 µM -0.450765269345861 0.374056008394343 no 2113 0.326079367582709 3248 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YBR252W DUT1
SGTC_1782 st039423 80.636 µM -0.451838524090065 0.373655832543946 no 2114 0.325692657274513 3208 2068169
SGTC_2853 9015042 58.44 µM -0.4526839971929 0.373340683668309 no 2115 0.325388152223514 3091 6457456
SGTC_3073 9114972 49.47 µM -0.452996343733906 0.373224278362551 no 2116 0.325275687159272 3266 41905075
SGTC_391 gliotoxin 8.33 µM -0.453296718806592 0.373112345496684 no 2117 0.325167547610594 3357 6223 A prooxidant peroxiredoxin mimetic; causes catalytic oxidation of thioredoxin and glutathione depletion
SGTC_3105 9121040 49.47 µM -0.454764741293027 0.372565450453246 no 2118 0.324639249371828 3234 41448907
SGTC_1557 sumaresinolic acid 42.3 µM -0.454824130663568 0.372543331018171 no 2119 0.32461788429339 3188 9982268 A natural terpine and antifungal of unknown mechanisn.
SGTC_51 1013-0126 23.419 µM -0.455345103721505 0.372349313820861 no 2120 0.324430491149889 3445 1627850
SGTC_7 0192-1582 4.227 µM -0.455563179375935 0.37226810920317 no 2121 0.324352062894017 3243 252616
SGTC_12 0849-0099 9.267 µM -0.456530035001413 0.371908150575949 no 2122 0.324004438918722 3265 6071388
SGTC_2218 6965428 192.983 µM -0.45693459528068 0.371757566703097 no 2123 0.323859028531045 3283 675684
SGTC_2340 7987427 183.45 µM -0.457066618614439 0.371708429729661 no 2124 0.323811581432919 3300 2239331
SGTC_32 0928-0142 34.1 µM -0.457148358197596 0.371678008611542 no 2125 0.323782206954478 3278 2244242
SGTC_2788 5282734 71.43 µM -0.458644008943419 0.371121512143042 no 2126 0.323244913933672 3342 743706
SGTC_2702 st077768 96.8 µM -0.46068098455559 0.370364034871193 no 2127 0.322513749799198 3261 6484119
SGTC_2763 lisinopril 49.32 µM -0.461472364301421 0.370069884820863 no 2128 0.322229872093357 3308 5362119 A lysine-analog of enalapril and an ACE inhibitor.
SGTC_835 0312-0010 67.2 µM -0.461899348966073 0.369911209297927 no 2129 0.322076750452449 3181 1626196
SGTC_3348 9149464 3.537 µM -0.463110341381346 0.369461302309773 no 2130 0.321642638900507 3260 1951442
SGTC_1555 citronellol 128 µM -0.464746355582258 0.368853775416769 no 2131 0.32105655390628 3281 8842 A terpine precursor.
SGTC_2882 9058044 58.44 µM -0.465324497643718 0.368639163078685 no 2132 0.320849547011377 3283 18076804
SGTC_2305 7443522 69.23 µM -0.46634255855301 0.368261347909341 no 2133 0.320485160181547 3250 5415886
SGTC_2255 7941087 197.44 µM -0.466625648576092 0.368156312268163 no 2134 0.320383866634829 3345 935561
SGTC_400 oxethazaine 37.5 µM -0.466942668862083 0.368038699089145 no 2135 0.320270448249804 3286 4621 A local anesthetic.
SGTC_2850 9015429 58.44 µM -0.467032874702743 0.368005235365539 no 2136 0.320238178932363 3250 6457570
SGTC_1890 3',4',7',8'-tetrahydroxyflavone 14.9 µM -0.468006615547683 0.367644069859032 no 2137 0.319889929398146 3362 688798
SGTC_3293 9120939 62.045 µM -0.469705688962422 0.367014155148346 no 2138 0.319282651408976 3333 934087
SGTC_79 0052-0007 94.094 µM -0.469926961260363 0.366932146926925 no 2139 0.319203600517892 3365 2801472
SGTC_2100 5377183 190 µM -0.470370430422906 0.366767806103259 no 2140 0.319045193175846 3287 2844202
SGTC_1061 3448-9325 110 µM -0.470544180943535 0.366703424282941 no 2141 0.318983138435244 3315 723482
SGTC_1311 1190-0148 100 µM -0.470561321706274 0.366697073118071 no 2142 0.318977016912171 3357 1961333
SGTC_2386 9075165 157.42 µM -0.472305486481425 0.366050999024057 no 2143 0.318354377398152 3294 16452277
SGTC_2144 5628481 200 µM -0.472309911622772 0.366049360343751 no 2144 0.318352798343405 3236 2818399
SGTC_913 3487-1245 167 µM -0.47236182606071 0.366030136017817 no 2145 0.318334273590747 3164 4016153
SGTC_2640 pentamidine 10.38 µM -0.472622689869165 0.365933541183399 no 2146 0.318241195813127 3304 4735 Thought to act by inhibiting tRNA aminoacylation and translation.
SGTC_96 0929-0093 37.281 µM -0.472631342266516 0.365930337446856 no 2147 0.318238108782238 3236 6991579
SGTC_101 0490-5701 117.494 µM -0.472742011822156 0.365889360483981 no 2148 0.318198624846297 3300 4661669
SGTC_3325 9138760 55.175 µM -0.473003836073634 0.365792422456339 no 2149 0.318105221184849 3231 43844959
SGTC_135 0933-0004 26.348 µM -0.473161563207692 0.365734029566969 no 2150 0.318048958901604 3351 21230617 YGL099W LSG1
SGTC_72 0744-0168 198.391 µM -0.473307505209223 0.36568000247665 no 2151 0.317996904190769 3144 677577
SGTC_883 0850-0245 24.6 µM -0.473909936031775 0.365457013431099 no 2152 0.317782066742766 3390 6823229 YPR165W RHO1
SGTC_1145 3546-0597 10.2 µM -0.475539924691271 0.364853903218592 no 2153 0.317201091678258 3270 875334
SGTC_225 nsc-122657 1.016 µM -0.476051591488089 0.364664650840203 no 2154 0.317018811620662 3317 275685
SGTC_1649 st011737 51.3 µM -0.478676390736535 0.363694324544734 no 2155 0.316084432047932 3286 1761035
SGTC_1173 0443-0020 122 µM -0.478714216530072 0.363680347613008 no 2156 0.316070975334674 3237 5331295
SGTC_1459 k035-0031 35.7 µM -0.479230053124678 0.363489759999729 no 2157 0.315887488238675 3193 3877128 YMR208W ERG12
SGTC_307 1501-1223 22.3 µM -0.480320942598877 0.363086817279287 no 2158 0.315499599773164 3302 2830329
SGTC_630 4356-0227 183 µM -0.480520760700716 0.363013026710348 no 2159 0.315428572294183 3316 779312
SGTC_3016 9080866 49.47 µM -0.480604301422676 0.36298217757227 no 2160 0.315398878873526 3238 17066299
SGTC_2613 3',4'-dimethoxydalbergione 24.65 µM -0.480896882330974 0.362874143035756 no 2161 0.315294894343717 3247 115019
SGTC_874 0599-0792 117 µM -0.48219260432441 0.36239583324328 no 2162 0.314834565051599 3401 765305
SGTC_3032 9089427 49.47 µM -0.482536367625098 0.36226897061777 no 2163 0.314712484992029 3317 17173707
SGTC_1731 st035964 63 µM -0.48545566980068 0.361192240406523 no 2164 0.313676575550287 3238 6739575
SGTC_3225 9130819 49.47 µM -0.485877897061471 0.361036600501599 no 2165 0.313526870197041 3358 4547121
SGTC_798 1287-0182 476 µM -0.487521601228839 0.360430923450004 no 2166 0.312944369331966 3389 1649755
SGTC_1506 4226-2149 212 µM -0.487691151465401 0.360368466960083 no 2167 0.312884310132079 3331 991114
SGTC_813 k007-0158 173 µM -0.487943413111805 0.360275549320382 no 2168 0.312794961543711 3284 6523916
SGTC_1928 4'-methoxychalcone 40.3 µM -0.489110954380763 0.359845606654667 no 2169 0.312381573239154 3429 641818
SGTC_535 2293-4129 48.2 µM -0.489153569572924 0.35982991712126 no 2170 0.312366489050366 3383 396118 YIL048W NEO1
SGTC_1345 1488-0192 31.4 µM -0.490060233064659 0.359496168998695 no 2171 0.312045638528503 3368 658348
SGTC_1435 4092-0789 56.7 µM -0.490305894137546 0.359405758162755 no 2172 0.311958728399877 3345 2248285
SGTC_590 k048-0076 22.4 µM -0.490474582534186 0.359343680198277 no 2173 0.311899055774484 3349 6832814
SGTC_2118 5526350 200 µM -0.490753960378411 0.359240876267435 no 2174 0.311800238203922 3329 743594
SGTC_562 3772-2733 112 µM -0.491723391690152 0.358884229306635 no 2175 0.311457449805805 3364 2876874 YIL048W NEO1
SGTC_195 4234-0266 16.654 µM -0.494086790634652 0.358015267385829 no 2176 0.310622443172614 3276 2303354
SGTC_1399 3562-5772 25 µM -0.49597151801181 0.357322827453505 no 2177 0.309957253058848 3289 23847490
SGTC_3345 9148410 3.559 µM -0.49769452683933 0.356690212888821 no 2178 0.309349683172774 3358 4903596
SGTC_2927 9011802 47.9 µM -0.498213336270946 0.356499805528162 no 2179 0.30916684178723 3362 43912568
SGTC_2443 5493264 126.67 µM -0.499017247648763 0.356204834043503 no 2180 0.30888361671823 3383 5340055
SGTC_2242 6630449 61.2675 µM -0.499039871615402 0.356196534092356 no 2181 0.308875647738026 3373 691249 YDR170C SEC7
SGTC_1696 st025591 34.7925 µM -0.49950104867061 0.356027359030613 no 2182 0.30871322409522 3312 2787147
SGTC_253 dyclonine 31.25 µM -0.49981556117319 0.355912001650914 no 2183 0.308602476235651 3365 3180 An oral anasthetic.
SGTC_1367 1812-0510 76.9 µM -0.502034760859055 0.355098415623566 no 2184 0.307821534759426 3321 1142582 YDR527W RBA50
SGTC_2884 9058502 51.95 µM -0.502531786809172 0.354916290122478 no 2185 0.307646749268877 3386 6471554
SGTC_2980 9014342 25.29 µM -0.503306143433257 0.354632608250348 no 2186 0.307374523915729 3423 2996599
SGTC_452 diindolylmethane 8 µM -0.503442316774337 0.35458273012273 no 2187 0.307326663091721 3364 3071 Inhibits expression of several cancer promoting factors.
SGTC_1411 3909-8223 150 µM -0.505917086705548 0.353676696458769 no 2188 0.306457428374185 3378 X1411
SGTC_2237 6667747 47.222 µM -0.507220727335105 0.353199755603136 no 2189 0.305999976585587 3221 729940 YDL015C TSC13
SGTC_3071 9117417 49.47 µM -0.507808660621324 0.352984733805315 no 2190 0.305793767763159 3264 45595590 YGL055W OLE1
SGTC_432 NS 1619 61.3 µM -0.508889333676692 0.352589627316955 no 2191 0.305414898419983 3402 4552 A K+/calcium channel activator.
SGTC_3317 9138495 8.753 µM -0.510480075833726 0.352008323033142 no 2192 0.304857584823488 3375 17020139
SGTC_411 enrofloxacin 100 µM -0.510641358811527 0.351949404737079 no 2193 0.304801104868783 3446 71188 A bacterial gyrase inhibitor.
SGTC_1801 st050089 28.441 µM -0.511384454651984 0.351677990279658 no 2194 0.304540939000651 3381 5008493 YIL048W | YNL267W NEO1 | PIK1
SGTC_2085 5307070 144.047 µM -0.511846393719715 0.351509305930168 no 2195 0.30437925896664 3262 2840351
SGTC_3297 9117502 71.43 µM -0.511917727656033 0.351483259821498 no 2196 0.304354295285256 3368 7453720
SGTC_589 1227-0070 34.1 µM -0.512482199629446 0.351277179176989 no 2197 0.304156787542092 3409 2841384
SGTC_2991 9074669 71.4286 µM -0.512692613904953 0.351200371116961 no 2198 0.304083178573912 3433 17333109
SGTC_2796 7949634 45.45 µM -0.513248263791168 0.350997570043619 no 2199 0.303888834431668 3330 2971588
SGTC_1537 2',6'-dihydroxyflavanone 78 µM -0.513487564453148 0.350910243167052 no 2200 0.303805153685379 3309 5106787 A p450 inhibitor.
SGTC_1187 1391-0724 117 µM -0.514153639750308 0.350667216885142 no 2201 0.303572288805524 3359 6997986
SGTC_1351 1496-0003 46.5 µM -0.514383256365993 0.350583452417079 no 2202 0.303492031605602 3409 3891978
SGTC_2790 5423970 71.43 µM -0.515855170125276 0.350046668875298 no 2203 0.302977783312834 3424 1376240 YKL165C | YIL048W MCD4 | NEO1
SGTC_1284 0929-0043 16 µM -0.517370348181973 0.34949442033919 no 2204 0.302448827306051 3348 1239883
SGTC_3094 9117742 49.47 µM -0.518987681957756 0.348905289646923 no 2205 0.301884665615265 3355 17149698
SGTC_644 1498-1197 63.3 µM -0.519018524480228 0.348894058469591 no 2206 0.301873911659191 3418 6741615
SGTC_360 0957-0399 1.01 µM -0.521257298578891 0.348079172255634 no 2207 0.301093771723279 3411 6752301 YPR165W RHO1
SGTC_356 1634-0012 32.5 µM -0.521270300713603 0.348074441682547 no 2208 0.30108924355708 3412 735457
SGTC_2798 7813637 45.45 µM -0.523022360400725 0.347437205446628 no 2209 0.300479346418656 3409 956368
SGTC_2757 clomiphene 4.22 µM -0.524093459710232 0.347047851341095 no 2210 0.300106768653475 3504 1548953 Clomifene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined.
SGTC_2588 indole-3-carbinol 100 µM -0.524407631548356 0.346933677687811 no 2211 0.299997524836421 3422 3712 Induces cell cycle arrest.
SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 200 µM -0.524964340059876 0.346731397555755 no 2212 0.299803990383111 3286 803109
SGTC_1543 azetidyl-2-carboxylic acid 198 µM -0.52506689906086 0.346694137488821 no 2213 0.299768342883102 3381 16486 A toxic proline analog.
SGTC_1154 4088-0362 150 µM -0.526604130459641 0.346135833460583 no 2214 0.299234261523743 3390 6618304
SGTC_2262 9014885 67.46 µM -0.527028178662052 0.345981883001429 no 2215 0.299087010177548 3352 6457424
SGTC_2976 9009005 19.48 µM -0.527146274542936 0.34593901288963 no 2216 0.299046007070785 3436 2993148
SGTC_2316 5844804 197.44 µM -0.527546416840429 0.345793771491103 no 2217 0.298907095908938 3382 776813
SGTC_897 1000-0139 31.4 µM -0.528407055034598 0.345481458793926 no 2218 0.298608420938128 3426 6151020
SGTC_947 3447-0010 211 µM -0.529530572905603 0.345073909272478 no 2219 0.298218720855691 3412 748350
SGTC_714 4296-0578 26.1 µM -0.529581564639271 0.345055416578055 no 2220 0.298201039509676 3343 1589775
SGTC_2226 7298446 200 µM -0.5306220214096 0.344678164729277 no 2221 0.297840366204483 3402 3283010
SGTC_3189 9110682 49.47 µM -0.531495276247203 0.344361656603467 no 2222 0.2975378069251 3401 17122418
SGTC_754 3474-0146 171 µM -0.53377629242777 0.34353542486512 no 2223 0.296748158995007 3273 24762078
SGTC_2163 5671233 125 µM -0.535145204667881 0.343039934637934 no 2224 0.296274726667217 3510 701023
SGTC_2943 9068529 45.32 µM -0.535843154341987 0.342787409193547 no 2225 0.29603347722113 3440 3270634
SGTC_2794 7785382 27.27 µM -0.536359281331085 0.342600714246288 no 2226 0.29585513361891 3445 2205081
SGTC_2263 7948595 193.29 µM -0.536529607457562 0.342539111821599 no 2227 0.295796289603557 3381 2971371
SGTC_2643 anethole 100 µM -0.536604339845839 0.342512084428447 no 2228 0.29577047286703 3408 637563 An anti-fungal, anti-helmenthic and channel blocker.
SGTC_662 k832-1615 104 µM -0.536887080361085 0.342409837010898 no 2229 0.295672807886545 3389 5878478
SGTC_3269 9137823 49.47 µM -0.537795789275934 0.342081298955468 no 2230 0.295359019650548 3301 17682936
SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 62.6 µM -0.538744882734707 0.341738287718262 no 2231 0.295031449825728 3435 756377
SGTC_2061 5245884 80.95 µM -0.538975509446564 0.341654956788163 no 2232 0.294951876673912 3359 573863
SGTC_2954 9074818 52.69 µM -0.539041962303293 0.341630947218364 no 2233 0.294928950275106 3435 16648742
SGTC_3065 9113888 49.47 µM -0.539423051122158 0.341493271328284 no 2234 0.294797489557351 3503 16648368
SGTC_1668 st014914 51.6 µM -0.540628044389256 0.341058082459245 no 2235 0.294381991937342 3440 2839556
SGTC_2482 5981709 142.65 µM -0.542620766685053 0.340338865617304 no 2236 0.293695468872583 3356 877755
SGTC_1925 st057770 10.1 µM -0.542681728143517 0.340316872436308 no 2237 0.293674478411203 3325 5989122
SGTC_3281 9140613 49.47 µM -0.542871996703478 0.340248232380473 no 2238 0.293608968945145 3379 16013766
SGTC_1333 1482-0047 286 µM -0.543380212897205 0.340064917547373 no 2239 0.293434023285113 3452 3811116
SGTC_1867 st057372 64 µM -0.545219242736792 0.339401891113363 no 2240 0.292801369252211 3435 688837
SGTC_1726 st035556 14.5795 µM -0.545838352781233 0.339178794712027 no 2241 0.292588528625202 3496 5919439
SGTC_3129 9127257 49.47 µM -0.546898858208244 0.338796772434069 no 2242 0.292224110101039 3302 837894
SGTC_3136 9095672 49.47 µM -0.550829923187534 0.337382146806907 no 2243 0.290875134711654 3350 17217380
SGTC_715 0868-0130 184 µM -0.551340898059556 0.337198436517018 no 2244 0.29070000370397 3495 2876258
SGTC_976 1348-1067 47.6 µM -0.551388784598594 0.337181221905545 no 2245 0.290683593648007 3434 5310671 YGL099W LSG1
SGTC_2653 dihydrofissinolide 100 µM -0.553166203320412 0.336542503546619 no 2246 0.290074803517728 3447 6857746
SGTC_1936 st074407 74.3 µM -0.553239511046684 0.336516170402235 no 2247 0.290049707459891 3363 809813
SGTC_2175 5807670 165.306 µM -0.553327894010023 0.33648442309124 no 2248 0.290019451921122 3420 241186
SGTC_1588 farnesol 29.9 µM -0.553402198024647 0.336457733864507 no 2249 0.28999401707795 3449 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_2397 5161689 200 µM -0.55404714983504 0.336226108531937 no 2250 0.289773288995246 3507 2259942
SGTC_2371 9071574 200 µM -0.555548640820632 0.335687110173976 no 2251 0.289259724853099 3440 45596039
SGTC_41 0478-0632 82.643 µM -0.556122915218599 0.335481049045352 no 2252 0.289063415434933 3479 3750424
SGTC_1559 coumarin 343 70.1 µM -0.556200685865166 0.335453147185921 no 2253 0.289036835208851 3490 108770 A hepatotoxic, DNA x-linker.
SGTC_3006 9075424 71.4286 µM -0.556305295880538 0.335415617568279 no 2254 0.289001083714516 3375 7465181
SGTC_1092 toremifene 6.32 µM -0.556381786026229 0.335388177201502 no 2255 0.288974943777025 3450 3005573 A first generation selective estrogen receptor modulator (SERM). Like tamoxifen, it is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on mammary and uterine tissue.
SGTC_1493 4348-0038 111 µM -0.557286471619001 0.335063693488985 no 2256 0.288665858631193 3479 800424
SGTC_2212 7123476 200 µM -0.557626253483039 0.334941855654614 no 2257 0.288549812650163 3413 1085715
SGTC_2963 9082507 9 µM -0.558674539246009 0.334566074387434 no 2258 0.288191929332452 3458 16459611
SGTC_808 0711-0032 135 µM -0.55925823440627 0.334356907695993 no 2259 0.287992747406686 3450 4252555
SGTC_2095 5432005 200 µM -0.559291972077755 0.334344819399768 no 2260 0.287981236647177 3380 783734
SGTC_1356 1502-0781 85.8 µM -0.559415591023214 0.334300527875151 no 2261 0.287939061675639 3385 567702
SGTC_332 4112-0506 40.9 µM -0.559440122923636 0.334291738596459 no 2262 0.287930692494625 3432 2790355
SGTC_2819 7996655 46.38 µM -0.560550670766725 0.333893947206668 no 2263 0.287551943866707 3351 6456960
SGTC_888 0916-0002 6.97 µM -0.561331493173343 0.333614373115337 no 2264 0.287285788098446 3504 2802138 YIL048W NEO1
SGTC_2544 sphondin 68.51 µM -0.56213644017659 0.33332625788333 no 2265 0.287011531169356 3501 108104 Sphondin is a coumarin of the psoralen class. YOR116C RPO31
SGTC_2441 5730946 39.09 µM -0.562973044540598 0.33302691569543 no 2266 0.286726619613111 3476 1774275
SGTC_1787 fluconazole 80 µM -0.563040012945408 0.333002958583625 no 2267 0.286703818844893 3418 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOL135C | YOR232W | YCL017C | YOL134C MED7 | MGE1 | NFS1 | YOL134C
SGTC_2551 apiole 73.87 µM -0.563354633593732 0.332890416093952 no 2268 0.286596711294495 3371 10659 A possible DNA adduct former.
SGTC_2540 epiandrosterone 100 µM -0.563359388068362 0.332888715493252 no 2269 0.286595092855489 3537 441302 A steroid.
SGTC_2338 7999974 200 µM -0.570164024278541 0.33045834211731 no 2270 0.284283227025963 3501 315925
SGTC_60 0986-0278 202 µM -0.570213099733726 0.330440839903902 no 2271 0.28426658613489 3332 3110598
SGTC_1253 0550-0034 176 µM -0.571387696351177 0.330022043870627 no 2272 0.283868433696026 3469 5969915
SGTC_2301 7769476 200 µM -0.57193101999019 0.329828396774816 no 2273 0.28368435388663 3431 977820
SGTC_1183 1254-0324 198 µM -0.572579871999599 0.32959719784354 no 2274 0.283464595660628 3491 5799357
SGTC_1370 2001-0092 44.6 µM -0.574072707851279 0.329065517957665 no 2275 0.28295930050087 3570 790957
SGTC_625 k213-0058 121 µM -0.574415111402842 0.328943618152487 no 2276 0.282843464726894 3506 3655420
SGTC_56 0957-0365 83.25 µM -0.576497529819932 0.328202644154716 no 2277 0.282139469514692 3489 6752360
SGTC_1664 st014217 9.02 µM -0.577273173526938 0.327926824163306 no 2278 0.281877466405753 3539 3982782
SGTC_2902 5787006 60.46 µM -0.577328412499469 0.327907184684395 no 2279 0.281858811818294 3413 591003
SGTC_628 1636-0253 16 µM -0.577648421689418 0.32779341905676 no 2280 0.281750754183316 3446 4456143
SGTC_183 3914-0051 30.55 µM -0.577702576903116 0.327774168059603 no 2281 0.281732469545809 3474 1596232
SGTC_791 1348-1292 225 µM -0.577856076326875 0.327719604850277 no 2282 0.281680646041162 3509 5437054
SGTC_2366 9070441 60.58 µM -0.578320305886486 0.327554611278959 no 2283 0.281523943768442 3412 6837235
SGTC_2225 6654152 15.4 µM -0.57909836878201 0.327278152545444 no 2284 0.281261400325582 3449 97582 YGR029W | YLR033W ERV1 | RSC58
SGTC_1259 0671-0132 43 µM -0.580569939407377 0.326755538012858 no 2285 0.280765168530782 3386 X1259
SGTC_3041 9091929 49.47 µM -0.58088232728774 0.326644640058951 no 2286 0.280659881982425 3572 25236887
SGTC_1945 st075991 56.6 µM -0.581083673892569 0.326573169965445 no 2287 0.280592030674195 3419 1084980
SGTC_521 r062-0005 13.8 µM -0.582407512269321 0.326103418221182 no 2288 0.28014611132331 3444 2832033
SGTC_740 k014-0057 261 µM -0.584309891577383 0.325428859666878 no 2289 0.279505919196857 3453 4012779
SGTC_2960 9079389 5.97 µM -0.585252918109642 0.325094686628266 no 2290 0.279188833772533 3493 16457355
SGTC_2578 7,8-dihydroxyflavone 64.44 µM -0.5856438642863 0.324956191269464 no 2291 0.279057432413576 3435 1880 Intensifies effect of antibiotics on Staphylococcus aureus.
SGTC_2645 abamectin 100 µM -0.586523085787072 0.324644809420731 no 2292 0.278762026206148 3489 5702208 Abamectin is an avermectin, primarily used as an antihelmentic. Avermectins work by inhibiting neuronal activity by activating glutamate-gated chloride channels.
SGTC_1164 k060-0068 93.7 µM -0.586552801855158 0.32463428742679 no 2293 0.278752044679998 3528 5963676
SGTC_2694 st077685 81.9 µM -0.588703790418724 0.323873028259797 no 2294 0.278029997382442 3442 2838096
SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 122.826 µM -0.588844290773259 0.323823329174635 no 2295 0.27798286576576 3494 616764
SGTC_703 3875-0075 71.8 µM -0.589083010888034 0.323738894089797 no 2296 0.277902794731251 3514 2850814
SGTC_2767 sibutramine 71.45 µM -0.59235853873622 0.322581260640987 no 2297 0.276805261998922 3571 64765 A serotonin-norepinephrine reuptake inhibitor.
SGTC_2457 5731572 11.68 µM -0.592612600835411 0.322491541939346 no 2298 0.27672022209434 3526 2865357
SGTC_2930 9013230 14.89 µM -0.592946575091435 0.322373619031432 no 2299 0.276608453394479 3506 2995857
SGTC_2082 5219693 150 µM -0.594149558600589 0.3219490060013 no 2300 0.276206043268798 3501 2834649
SGTC_2368 9071271 200 µM -0.595140769862365 0.32159931607369 no 2301 0.275874689134142 3462 27209959
SGTC_2913 7966556 36.57 µM -0.59568506697833 0.321407360400889 no 2302 0.27569281798694 3487 2976516
SGTC_996 3970-0799 1.8 µM -0.596225241049768 0.321216905935235 no 2303 0.275512382801783 3563 6615648 YGL040C HEM2
SGTC_2861 9024595 19.48 µM -0.599210555379263 0.320165193340446 no 2304 0.274516242404779 3444 16482810
SGTC_2181 6316240 54.2555 µM -0.59931911272059 0.320126976230604 no 2305 0.274480052477771 3498 12779990
SGTC_1710 st031758 61.5 µM -0.599471215430824 0.320073432385191 no 2306 0.274429349725087 3561 5394341
SGTC_2828 7998861 71.43 µM -0.600908132129434 0.319567787878197 no 2307 0.27395058825197 3469 2988188
SGTC_943 3253-1379 105 µM -0.601361838902799 0.319408200105654 no 2308 0.273799505012207 3532 668464
SGTC_573 3702-0553 84.7 µM -0.601765506025115 0.319266241499864 no 2309 0.273665119500818 3516 1222756
SGTC_3078 9116413 49.47 µM -0.602144247911973 0.319133072501329 no 2310 0.273539061570996 3453 17177322
SGTC_22 0964-0034 14.468 µM -0.602963724565925 0.318845017147884 no 2311 0.273266410811923 3509 138402
SGTC_3303 9125618 40.5795 µM -0.603259385886477 0.318741115681449 no 2312 0.27316807342376 3501 22695467
SGTC_1043 0916-0009 19.3 µM -0.604079593197084 0.31845295257343 no 2313 0.272895363099431 3562 3101130
SGTC_680 0417-1641 114 µM -0.60518385857123 0.318065164890346 no 2314 0.272528419834119 3463 2835990
SGTC_2906 7926292 26.41 µM -0.605225347575377 0.31805059897466 no 2315 0.272514637969185 3528 2966319
SGTC_1602 st001878 87.6 µM -0.605587416475657 0.317923496155 no 2316 0.272394380196378 3559 595405 YLR310C CDC25
SGTC_389 tpck 16.7 µM -0.606222746362113 0.317700518014069 no 2317 0.272183425090491 3501 439647 TPCK, N-p-Tosyl-L-phenylalanine chloromethyl ketone, is a serine/cysteine protease inhibitor capable of alkylating nucleophilic residues at the α-chloro ketone, irreversibly disabling the protease.
SGTC_1340 1486-1359 257 µM -0.606725828054021 0.317524001165449 no 2318 0.272016439337745 3458 4309068
SGTC_1788 fluconazole 20 µM -0.608865852104094 0.316773592399951 no 2319 0.271306680106812 3511 3365 Fluconazole is a triazole antifungal; inhibits lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YHR007C ERG11
SGTC_354 2783-3500 4.88 µM -0.609659781593544 0.316495388962271 no 2320 0.271043600805305 3477 6740761
SGTC_629 3448-6466 76.7 µM -0.613016351273171 0.315320350922959 no 2321 0.269932764032323 3546 573744
SGTC_1408 3909-7976 48.8 µM -0.613497076694743 0.315152215300301 no 2322 0.269773857557555 3533 24152374
SGTC_2564 betulinic acid 100 µM -0.616260269358134 0.314186521072508 no 2323 0.268861378230476 3594 6708517 Apoptosis-inducing agent of unknown mechanism. YBR070C ALG14
SGTC_2523 spermine 47.74 µM -0.616801514342068 0.313997512717945 no 2324 0.268682826511638 3520 1103 A DNA binding polyamine.
SGTC_2364 9055074 200 µM -0.618743725936778 0.313319674207393 no 2325 0.268042599727031 3513 6470630
SGTC_1410 3909-8106 77.9 µM -0.618873198556804 0.313274510198136 no 2326 0.267999947949923 3561 1039210
SGTC_297 0986-0032 24 µM -0.621307707334495 0.312425801097843 no 2327 0.267198591775016 3506 2847425
SGTC_428 3448-4153 16.5 µM -0.621543205202092 0.312343755395062 no 2328 0.267121138215465 3497 3834874
SGTC_2440 5628896 157.78 µM -0.622001517252875 0.312184109563704 no 2329 0.266970435170254 3548 5522048
SGTC_837 0091-0265 12.5 µM -0.624621380699241 0.311272198729732 no 2330 0.26610979182419 3511 759367
SGTC_1622 st003707 19.4 µM -0.626326263866796 0.310679391335381 no 2331 0.265550481474808 3566 10140899
SGTC_456 gingerol 170 µM -0.626388320590292 0.310657822758303 no 2332 0.26553013416718 3624 442793 A herb.
SGTC_2598 perillyl alcohol 100 µM -0.626985531391277 0.310450288078568 no 2333 0.265334359692429 3569 10819 An apoptosis inducer.
SGTC_1443 4112-3303 14 µM -0.62698594203722 0.310450145397151 no 2334 0.265334225101866 3556 704433
SGTC_1110 3-hydroxy-3'-methoxyflavone 1.24133 µM -0.627774479072947 0.31017621606529 no 2335 0.265075843424353 3584 676296 Flavone; oxidizing agent.
SGTC_2480 5767542 37.17 µM -0.627879759806376 0.310139650629319 no 2336 0.265041355527226 3562 2867358
SGTC_838 0109-0203 71.4 µM -0.628158377641537 0.310042891910004 no 2337 0.264950096805735 3573 759422
SGTC_978 1416-0512 87.4 µM -0.632908902455613 0.308395152727468 no 2338 0.263396566956537 3586 6814003
SGTC_110 0850-0284 111.64 µM -0.633516590037309 0.308184651012008 no 2339 0.263198175293977 3459 3906265
SGTC_836 0330-0104 1.35 µM -0.635562685221504 0.307476351896803 no 2340 0.262530748605497 3574 46494820
SGTC_869 0564-0080 44.1 µM -0.636361952577435 0.307199863267693 no 2341 0.26227026682496 3540 6843321
SGTC_2581 avocatin a 64 µM -0.638482770416958 0.306466745255235 no 2342 0.261579733116795 3547 6710728 A skin care supplement.
SGTC_281 1672-3440 14.9 µM -0.638858802270559 0.30633684037157 no 2343 0.261457395431488 3572 6833000
SGTC_2846 9008642 19.48 µM -0.639109467473655 0.306250258476244 no 2344 0.261375860682324 3561 2992898
SGTC_425 3825-7017 13.1 µM -0.639242034684411 0.306204473006576 no 2345 0.261332745361143 3618 3397440
SGTC_1623 st003709 20.3 µM -0.639411056972722 0.306146101234979 no 2346 0.261277778919904 3576 16192618
SGTC_1468 k284-1086 134 µM -0.641172793460727 0.305537979522905 no 2347 0.260705211920403 3599 15996457
SGTC_1718 roemerine 11.9335 µM -0.641343719193836 0.305479007346571 no 2348 0.260649695183379 3559 235224 An aporphine alkaloid with mutagenic activity.
SGTC_3156 9099931 49.47 µM -0.643130557220276 0.304862821346727 no 2349 0.260069694089865 3580 18111053
SGTC_3095 9117207 49.47 µM -0.64330815742931 0.304801606608066 no 2350 0.260012082088516 3554 17015229
SGTC_665 3914-0008 307 µM -0.643757734261165 0.304646672159788 no 2351 0.259866272599139 3557 1069549
SGTC_1695 st026914 34.495 µM -0.645605853463214 0.304010136330576 no 2352 0.259267322774525 3561 3289191
SGTC_105 0111-0055 734.78 µM -0.645699356452606 0.303977947459035 no 2353 0.259237038722707 3539 5179370
SGTC_722 3534-0461 190 µM -0.64642654273196 0.303727661828293 no 2354 0.259001577683431 3560 658262
SGTC_2008 4012253 172 µM -0.647098227604608 0.303496560614501 no 2355 0.258784186166047 3598 603940
SGTC_310 1273-0058 1.06 µM -0.64722351391525 0.303453463053476 no 2356 0.258743647571449 3615 2734232
SGTC_1751 st044839 27.194 µM -0.64878008131159 0.302918243580423 no 2357 0.258240266977372 3604 5291326
SGTC_2347 9049783 174.81 µM -0.649163087557545 0.302786613220392 no 2358 0.25811648389456 3590 6467988 YPL169C MEX67
SGTC_2552 juarezic acid 87.02 µM -0.65029996419356 0.302396046053868 no 2359 0.25774924010798 3661 1549512
SGTC_417 st075190 100 µM -0.650571586717941 0.302302765211608 no 2360 0.257661538394211 3613 222757
SGTC_2505 galangin 7.89 µM -0.650854630000543 0.30220557598028 no 2361 0.257570165623724 3527 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_2298 7976326 193.81 µM -0.651744685871731 0.301900046848218 no 2362 0.257282945166953 3500 2235818
SGTC_2635 hydroquinidine 100 µM -0.652840211501047 0.301524176862682 no 2363 0.256929648446184 3588 442912 An experimental heart treatment.
SGTC_1197 1601-0112 267 µM -0.653002453450074 0.301468530274087 no 2364 0.256877348409811 3587 7350313
SGTC_1864 st057645 30.4 µM -0.653978903888024 0.301133719875432 no 2365 0.256562698568789 3637 688666
SGTC_1949 st076024 69.1 µM -0.655102756714164 0.300748574915596 no 2366 0.256200798662462 3584 2921930
SGTC_246 cycloheximide 667 µM -0.655190389028439 0.300718552618685 no 2367 0.256172590743156 3491 16760040 Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells.
SGTC_2324 6149169 200 µM -0.655723153245616 0.300536059957079 no 2368 0.256001134408177 3532 2888231
SGTC_586 0957-0265 8.15 µM -0.656829164998454 0.300157367280839 no 2369 0.255645384475501 3524 6752309 YPR165W | YPR107C RHO1 | YTH1
SGTC_1680 diphenhydramine 100 µM -0.659731457160986 0.29916466512227 no 2370 0.254713087983481 3599 8980 A first generation anti-histamine possessing anticholinergic, antitussive, antiemetic and sedative properties. YIL048W NEO1
SGTC_2503 beta-caryophyllene alcohol 24.72 µM -0.660099909514588 0.299038746068182 no 2371 0.254594858381418 3602 61125 An anti-inflammatory.
SGTC_1502 4534-4282 27.7 µM -0.661426916430842 0.298585439334052 no 2372 0.254169284516824 3594 3278949
SGTC_2555 cholic acid 100 µM -0.663013370291743 0.298043915833179 no 2373 0.253660995520075 3625 6708657 Influences liver metabolism.
SGTC_2020 4017018 200 µM -0.663402004463403 0.297911326905521 no 2374 0.253536561239041 3629 21127491 Used for adrenal and myocardial imaging when labeled with iodine radioisotope.
SGTC_1698 5-fluorocytosine 1.055 µM -0.663410870417604 0.297908302453462 no 2375 0.253533722880272 3642 3366 The mechanism of 5-fluorocytosine (5-FC) is identical to 5-fluorouracil (5-FU) and acts by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex. The specificity of 5-FC for fungi is due to the requirement for the fungal specific cytosine permease in addition to cytosine deaminase that acts to convert 5-FC to 5-FU.
SGTC_1773 st048542 73.5835 µM -0.663590050583973 0.297847181539954 no 2376 0.253476363473665 3563 3237138
SGTC_1943 st076331 65.2 µM -0.664689586360105 0.297472239465741 no 2377 0.253124527903089 3670 24208415
SGTC_643 k048-0106 28.4 µM -0.665536216957604 0.297183685098511 no 2378 0.252853793485023 3627 6763920
SGTC_701 4424-0219 185 µM -0.668848978908977 0.296055838955691 no 2379 0.251795909682887 3656 2911779
SGTC_2868 9035608 32.47 µM -0.671473260416136 0.29516378635584 no 2380 0.250959544138502 3624 6462614
SGTC_2801 7907800 81.82 µM -0.671684974237748 0.295091874021959 no 2381 0.250892134522727 3652 6620925
SGTC_357 1325-0123 420 µM -0.672882502711543 0.294685264338777 no 2382 0.250511022319571 3612 1098503
SGTC_2498 4'-Methoxychalcone 54.63 µM -0.673655607266857 0.294422901195579 no 2383 0.250265145631671 3569 641818 YHR062C RPP1
SGTC_1243 0416-0003 5.65 µM -0.674204142519746 0.294236814005372 no 2384 0.250090768169769 3629 2141977
SGTC_688 0527-0193 473 µM -0.674490759476595 0.294139602592526 no 2385 0.249999679274407 3636 4007154
SGTC_2282 7944268 200 µM -0.674969787222039 0.293977164660948 no 2386 0.249847480177759 3672 2970414
SGTC_3221 9128209 49.47 µM -0.675513173710875 0.293792952956885 no 2387 0.249674892261831 3662 16460723
SGTC_2186 6124449 200 µM -0.6755329903317 0.293786235997518 no 2388 0.249668599394824 3595 3834182 YLR033W RSC58
SGTC_608 k048-0125 159 µM -0.67613770400635 0.293581298941033 no 2389 0.249476610058359 3659 6817652 YLR060W | YFL022C FRS1 | FRS2
SGTC_1407 3909-7909 12.3 µM -0.680199855875548 0.292206357336205 no 2390 0.248188961800494 3656 4411780
SGTC_1098 clofazimine 15.1 µM -0.680910813931775 0.291966023372861 no 2391 0.247963962541471 3686 2794 Several studies have pointed to inhibition of K+ transport. However, it is not clear whether inhibition results from a specific interaction(s) or is a consequence of membrane disruption. CFZ also is reported to bind to DNA YEL034W HYP2
SGTC_169 k015-0017 16.025 µM -0.681359323203745 0.291814455588838 no 2392 0.247822077334925 3686 1840002
SGTC_1647 st011722 22.4 µM -0.68264667575703 0.291379615538266 no 2393 0.247415066222441 3646 2854783
SGTC_49 0717-0965 32.132 µM -0.683430168334931 0.291115116650835 no 2394 0.247167531145025 3735 5889349 YGL099W LSG1
SGTC_1972 st070201 17.4 µM -0.684700231477153 0.290686595010357 no 2395 0.24676655147466 3635 2829099
SGTC_1887 st057648 70.8 µM -0.685653319103591 0.290365215387796 no 2396 0.246465875049385 3639 688672
SGTC_1403 3909-7815 62.9 µM -0.687455503468794 0.289757976851877 no 2397 0.24589786582438 3611 6615483
SGTC_1285 0929-0069 65.5 µM -0.6876915295073 0.289678493008852 no 2398 0.24582352762621 3662 1206237
SGTC_2196 6573537 42.6665 µM -0.687828636350355 0.289632325773666 no 2399 0.245780350321696 3692 2903087
SGTC_2122 5258151 111.688 µM -0.689285950431763 0.289141825993223 no 2400 0.245321668763048 3653 2173356
SGTC_393 acivicin 6.25 µM -0.68983220035793 0.288958071010983 no 2401 0.245149858248095 3573 16758175 Acivicin is a glutamine analog antimetabolite, used as an antineoplastic agent. It interferes with glutamate metabolism and inhibits glutamate dependent synthesis of enzymes, and is thereby potentially helpful in treatment of solid tumors. is an irreversible inhibitor of γ-glutamyl transpeptidase. YPR035W GLN1
SGTC_1605 st000082 49.1 µM -0.689897504877961 0.288936106665608 no 2402 0.245129322524938 3671 1114022
SGTC_1817 st052116 64.4 µM -0.690558465696479 0.288713845120517 no 2403 0.244921528217585 3666 4361398
SGTC_2667 digitoxin 100 µM -0.690718280983863 0.288660116062727 no 2404 0.244871299371777 3624 5702041 Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin, a spirostan steroid. As a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_776 4476-4378 112 µM -0.693215709524023 0.287821106197687 no 2405 0.244087095468179 3673 2892008
SGTC_1220 1838-0075 193 µM -0.694631475322495 0.287345992525711 no 2406 0.243643140865295 3613 5529645
SGTC_2787 5284540 71.43 µM -0.697705104238624 0.28631579943326 no 2407 0.242680817704766 3683 736958
SGTC_198 3454-2873 16.191 µM -0.697910039874969 0.286247173231721 no 2408 0.242616727616491 3671 710957
SGTC_1371 2421-0008 32.7 µM -0.698754191374559 0.285964577052919 no 2409 0.242352830435828 3662 2827552
SGTC_2296 7971656 126.45 µM -0.698811325954236 0.285945454930468 no 2410 0.24233497474401 3718 666570
SGTC_1331 1472-0049 76.2 µM -0.700073722921973 0.285523103974507 no 2411 0.241940632544711 3648 24051409
SGTC_2126 5251174 33.877 µM -0.700859433752231 0.285260384444182 no 2412 0.241695371393954 3701 790722
SGTC_266 formosanin C 406 nM -0.701582242978198 0.285018799194728 no 2413 0.241469864338501 3656 73597 Formosanin C is a saponin glycoside isolated from the plant Paris formosana Hayata. The amphipathic nature of saponins gives them activity as surfactants that can be used to enhance penetration of macromolecules through cell membranes. YMR211W DML1
SGTC_2157 5649910 96.377 µM -0.702885876814694 0.284583331168557 no 2414 0.24106343666171 3658 2858091
SGTC_3275 9138069 49.47 µM -0.704096030420047 0.284179374009247 no 2415 0.240686486021078 3734 17617007
SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150 µM -0.704774015742343 0.283953177990808 no 2416 0.240475440733092 3697 2374 Ca(2+)-ATPase inhibitor.
SGTC_80 0159-0065 512.242 µM -0.70521820254509 0.283805030823649 no 2417 0.240337227604127 3629 1548079
SGTC_2139 5578692 56.4705 µM -0.707671438242465 0.282987483973951 no 2418 0.239574659116685 3635 650991 YMR113W FOL3
SGTC_1477 0139-0234 16 µM -0.708479095730988 0.282718577717424 no 2419 0.239323894622201 3692 620880
SGTC_1823 3-hydroxy-2-naphthoic acid 106 µM -0.711262331714743 0.281792852430124 no 2420 0.238460844607174 3669 7104
SGTC_3242 9133940 49.47 µM -0.712272377857915 0.281457265120148 no 2421 0.238148062640018 3723 17248444
SGTC_2878 9043973 25.97 µM -0.713411727791612 0.281078948285704 no 2422 0.237795509032344 3751 6465167
SGTC_440 fluspirilene 35.1 µM -0.714812067632086 0.280614307520595 no 2423 0.237362588685383 3751 3396 An atypical antipsychotic.
SGTC_2601 securinine 100 µM -0.715903034857469 0.280252576086644 no 2424 0.237025612192452 3670 442872 A GABA receptor antagonist.
SGTC_255 tunicamycin 200.472 nM -0.715978425305981 0.280227587261144 no 2425 0.237002335407925 3682 23847177 Tunicamycin inhibits GlcNAc phosphotransferase (GPT), which catalyzes the transfer of N-actelyglucosamine-1-phosphate from UDP-N-acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthesis. Tunicamycin is used as a chemical tool in research to induce the unfolded protein response pathway. YBR243C ALG7
SGTC_1359 1582-0056 520 nM -0.717091436315122 0.279858795651333 no 2426 0.23665883972943 3758 3661189
SGTC_1447 4239-0816 81.9 µM -0.717111403307489 0.279852181820721 no 2427 0.236652680049775 3704 1341554
SGTC_1046 2001-0062 216 µM -0.717117161718026 0.279850274429265 no 2428 0.236650903636162 3639 739778
SGTC_2213 7173844 200 µM -0.717346160771522 0.279774426866994 no 2429 0.236580265603329 3688 892728
SGTC_2370 9071495 200 µM -0.718161652847352 0.279504405964069 no 2430 0.236328809653841 3659 21791103
SGTC_911 3456-4043 236 µM -0.723342308942776 0.277791979601829 no 2431 0.23473480272362 3794 914281
SGTC_226 1,3-diallylurea 8.28947 mM -0.724145813742372 0.277526846807274 no 2432 0.234488110406772 3667 74537 YKL182W FAS1
SGTC_1523 st012844 44.7 µM -0.724585359577178 0.277381862041767 no 2433 0.234353221609968 3803 4274103
SGTC_1808 st050063 61.5 µM -0.7255304808468 0.277070238040114 no 2434 0.234063326200125 3692 4011993
SGTC_1079 idarubicin 2.36 µM -0.725613645313202 0.277042825377862 no 2435 0.23403782681785 3680 636362 Idarubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2550 chrysin dimethyl ether 71.87 µM -0.725658684122282 0.277027980244719 no 2436 0.234024017934762 3564 88881 An O-methylated flavonoid and antioxidant.
SGTC_871 0574-0004 149 µM -0.727459439812621 0.276434756717773 no 2437 0.233472276759186 3702 9551173
SGTC_259 usnic acid 108.925 µM -0.727498604127936 0.276421861729787 no 2438 0.233460285060771 3795 5646 An anti-infective, antifungal and antitrichomonal agent.
SGTC_365 0121-0052 13.6 µM -0.72754634272362 0.276406144028919 no 2439 0.2334456684706 3739 3101739
SGTC_3061 glucosamine 200 µM -0.72839805308511 0.276125796222593 no 2440 0.233184977363208 3641 91431 and experimental redox chemotherapeutic
SGTC_1342 1486-1464 234 µM -0.728668975177621 0.276036649151614 no 2441 0.233102087545964 3753 3253938
SGTC_984 1492-0255 2.91 µM -0.729715666422339 0.275692367623011 no 2442 0.232782001453924 3676 1585198
SGTC_817 1391-0715 46 µM -0.730778406305448 0.275343023414578 no 2443 0.232457257601424 3708 1353946
SGTC_1301 naphtanilide LB 4.81 µM -0.731014949769345 0.27526529641891 no 2444 0.232385010770783 3768 67238 An a1-adrenergic receptor antagonist or alpha blocker.
SGTC_550 4123-0385 25.7 µM -0.73125220896827 0.275187345087441 no 2445 0.232312557883494 3746 5731123
SGTC_2183 6420625 130.508 µM -0.733461970254357 0.274461852133291 no 2446 0.231638357283698 3744 2897619
SGTC_488 nitrendipine 139 µM -0.733613531368411 0.274412127287297 no 2447 0.231592155815021 3759 4507 Dihydropyridine L-type calcium channel blocker.
SGTC_1112 tnp00069 1.16933 µM -0.736058974664747 0.273610430561647 no 2448 0.230847404106583 3788 145826
SGTC_641 4092-0595 30 µM -0.737307430788169 0.273201592930099 no 2449 0.230467707195453 3772 786260
SGTC_1987 st072290 61.9 µM -0.738236288086987 0.272897612278092 no 2450 0.230185437519456 3740 54697379
SGTC_2971 9092186 9.93 µM -0.738533119382577 0.272800505747803 no 2451 0.230095274493714 3753 25236400
SGTC_33 0986-0033 35.816 µM -0.7386555402926 0.272760461494235 no 2452 0.23005809468403 3674 2848082
SGTC_2651 TUB2.036 5 µM -0.739277238528593 0.272557147124604 no 2453 0.229869333881012 3817 15992207 YFL037W TUB2
SGTC_1263 0774-1208 64.8 µM -0.740124294358188 0.272280255062057 no 2454 0.229612289322751 3756 906585
SGTC_1600 coumarin 106 71.1 µM -0.740691220524291 0.272095012029585 no 2455 0.229440341905943 3822 100336 A hepatotoxic, DNA x-linker.
SGTC_2328 6201408 200 µM -0.740971807405128 0.272003353497164 no 2456 0.229355267246966 3748 2890418
SGTC_1599 8-chlro-1-tetrahydronorharmanone 90.6 µM -0.741521628860475 0.271823789395217 no 2457 0.229188611263011 3763 4174840
SGTC_328 k915-0120 63.5 µM -0.744228609530224 0.270940587856924 no 2458 0.228369091300424 3746 6624543
SGTC_1070 indatraline 8.81 µM -0.745575995974723 0.270501512937309 no 2459 0.22796179385576 3751 10314472 A monamine transport inhibitor. YGL099W LSG1
SGTC_2526 patulin 37.61 µM -0.74665813558181 0.270149132028349 no 2460 0.227634973194085 3801 4696 Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase. It induces intra- and intermolecular protein crosslinking.
SGTC_239 5hr heat shock (37°C) + mitomycin C 819.444 µM -0.747673702176417 0.269818638506971 no 2461 0.227328498572986 3747 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 49.5065 µM -0.747995155296919 0.26971407094654 no 2462 0.22723153988249 3706 279621
SGTC_3177 9107506 49.47 µM -0.748050516117093 0.26969606431702 no 2463 0.227214843960259 3670 8897194
SGTC_1011 4112-3381 17.4 µM -0.750197292821887 0.268998269662341 no 2464 0.226567944518875 3821 2877139
SGTC_38 0929-0051 58.268 µM -0.751181624747832 0.268678622803046 no 2465 0.226271678642932 3773 1379719
SGTC_401 neomycin 50 µM -0.751371545900338 0.268616970761128 no 2466 0.226214541053347 3754 8378 Neomycin is an aminoglycoside antibiotic; inhibits initiation and elongation during protein synthesis.
SGTC_355 1311-2252 105 µM -0.751636975176417 0.268530819249627 no 2467 0.226134700579752 3762 5338538
SGTC_130 0136-0219 337.655 µM -0.752284028658225 0.268320860559146 no 2468 0.225940135226454 3687 234244
SGTC_1995 st072814 61.1 µM -0.752367015864953 0.268293938489744 no 2469 0.225915188288657 3734 5769371
SGTC_687 k029-0044 34.9 µM -0.753299180782268 0.267991626124318 no 2470 0.225635075493168 3773 5829338
SGTC_2192 5915882 198.485 µM -0.753387974155412 0.267962838308255 no 2471 0.225608403602836 3727 2876149
SGTC_2994 9053520 71.4286 µM -0.753416122636658 0.267953712577279 no 2472 0.225599948691088 3792 4647384
SGTC_434 1-hexadecyl-2-methylglycero-3 PC 8 µM -0.753808404156715 0.267826551291303 no 2473 0.225482138416539 3794 1377
SGTC_2543 pimpinellin 60.67 µM -0.75500055260002 0.26744029322066 no 2474 0.225124325326346 3668 4825 From Heracleum laciniatum; cause of phototoxicity in patient with vitiligo.
SGTC_3235 9132602 49.47 µM -0.755398857665032 0.26731130436404 no 2475 0.225004849223724 3768 4912240
SGTC_2705 st078069 42.8 µM -0.75631277774089 0.267015455174366 no 2476 0.224730844439591 3783 1530061
SGTC_793 0488-0545 106 µM -0.756606078288837 0.266920544592114 no 2477 0.224642949355556 3768 292548
SGTC_528 3492-0019 172 µM -0.757405057038146 0.266662085558939 no 2478 0.22440361367456 3783 2869262
SGTC_1725 st036284 20.55 µM -0.757962418227701 0.266481861548133 no 2479 0.224236740744802 3815 707914
SGTC_1320 1313-0481 95.3 µM -0.759980298682044 0.265829891034173 no 2480 0.223633180661976 3764 6813365 YLR208W SEC13
SGTC_774 k060-0086 136 µM -0.760013850205029 0.265819057484462 no 2481 0.223623153015288 3780 5911235
SGTC_1313 1220-0047 237 µM -0.760796135032611 0.265566526691157 no 2482 0.223389421640834 3771 3528706
SGTC_971 1315-0384 26.7 µM -0.761222676110762 0.265428885468661 no 2483 0.223262038107543 3794 6769120
SGTC_2536 dehydroabietamide 32.04 µM -0.761667325233246 0.265285439479874 no 2484 0.223129290757069 3784 3983547
SGTC_3354 9151612 71.43 µM -0.762396888857993 0.265050163964255 no 2485 0.222911581264216 3801 27261949
SGTC_3324 9138759 60.749 µM -0.762501274970595 0.265016509365892 no 2486 0.222880441244146 3807 45595710
SGTC_2128 5255449 168.493 µM -0.763271529948191 0.264768242490863 no 2487 0.222650738691015 3785 736008
SGTC_1048 3161-0300 24.5 µM -0.763575458897112 0.26467031333236 no 2488 0.22256013928085 3775 2165101
SGTC_383 2324-0395 7.37 µM -0.765107701430711 0.264176889097362 no 2489 0.222103707134521 3808 3146421
SGTC_1496 4469-0713 57.4 µM -0.766849223142659 0.263616640674553 no 2490 0.221585583200071 3748 746691
SGTC_1983 st071813 46.9 µM -0.768298188035673 0.263150970358603 no 2491 0.221155025455888 3843 11838595
SGTC_964 1287-0107 19.4 µM -0.769297356744064 0.262830101156828 no 2492 0.220858403015967 3791 51516812 YPR165W RHO1
SGTC_1024 4507-0395 26 µM -0.76993375415175 0.262625835290874 no 2493 0.220669595014895 3847 4201836
SGTC_1169 aniline yellow 25.8 µM -0.771226475378446 0.262211157980808 no 2494 0.220286351983193 3725 6051 A DNA damaging agent.
SGTC_2966 9084041 48.03 µM -0.771282367218215 0.262193236642878 no 2495 0.220269790773987 3744 17741380
SGTC_1795 st049545 62.3 µM -0.771770085953004 0.262036879586827 no 2496 0.220125306021887 3726 5291882
SGTC_986 1493-0483 84 µM -0.774564221216932 0.2611420339267 no 2497 0.219298602970583 3715 40079
SGTC_3081 9117243 49.47 µM -0.775860290845957 0.260727490436295 no 2498 0.218915740431304 3817 45595589
SGTC_1816 st051957 91.6 µM -0.776285695157546 0.260591500155953 no 2499 0.218790158691887 3782 674121
SGTC_2720 fluspirilene 36.88 µM -0.776346975476401 0.260571913500686 no 2500 0.218772071814499 3761 3396 An atypical antipsychotic.
SGTC_1644 st010134 20.9 µM -0.777964318555022 0.260055246083366 no 2501 0.218295024355501 3787 3818134
SGTC_1305 1181-0477 144 µM -0.778106008392405 0.260010007814043 no 2502 0.218253260447001 3815 6252086
SGTC_544 k015-0020 52.4 µM -0.77880096932604 0.259788181731997 no 2503 0.218048483325584 3808 3008304
SGTC_2952 9073731 13.78 µM -0.779056311178284 0.259706703152691 no 2504 0.217973272152601 3858 16457353
SGTC_3204 9114183 49.47 µM -0.7790570324372 0.259706473020494 no 2505 0.217973059726324 3824 17027248
SGTC_1585 2',4'-dihydroxychalcone 10.4 µM -0.78246014358078 0.258621814808159 no 2506 0.216972099918521 3803 5357218 A potent inhibitor of glutathione S-transferases.
SGTC_3322 9139058 2.11 µM -0.783692774372107 0.258229523406812 no 2507 0.216610201669951 3924 4908926 YPR165W RHO1
SGTC_3307 9126885 69.2785 µM -0.784698896212997 0.257909548486228 no 2508 0.216315065054005 3798 24824909
SGTC_2490 carminic acid 95.39 µM -0.786085882813728 0.257468785399916 no 2509 0.21590858714099 3727 14749 Coloring matter from the insect Coccus cacti L. It is used in foods, pharmaceuticals, toiletries, etc., as a dye, and also has use as a microscopic stain and biological marker.
SGTC_1431 4049-0260 9.09 µM -0.788042046425404 0.25684781237783 no 2510 0.215336056041006 3782 3854841
SGTC_2252 omeprazole 400 µM -0.788045909189896 0.256846586936738 no 2511 0.215334926357028 3758 4594 A proton pump inhibitor.
SGTC_2953 9074162 66.49 µM -0.788350904492948 0.256749838436298 no 2512 0.215245739875322 3748 16451992
SGTC_3238 9133470 49.47 µM -0.788550451127567 0.256686549901183 no 2513 0.215187400211794 3790 3534688
SGTC_1239 0337-0584 35.4 µM -0.789457023516941 0.256399122240488 no 2514 0.214922469351334 3870 914301 YML130C ERO1
SGTC_2363 9053361 176 µM -0.789784355572112 0.256295383241284 no 2515 0.214826858515101 3859 6469797 YMR079W SEC14
SGTC_501 nsc-95397 161 µM -0.790030775320148 0.256217301636253 no 2516 0.21475489776308 3826 262093
SGTC_236 1509-0011 5.31 µM -0.792224961884072 0.255522589658677 no 2517 0.214114758078036 3880 3107280
SGTC_3181 9108277 49.47 µM -0.792299391384013 0.255499041444392 no 2518 0.214093063244283 3768 17097298
SGTC_2693 st077581 40.7 µM -0.794035301765737 0.254950150993945 no 2519 0.213587440174232 3873 25238761
SGTC_64 000l-0018 272.079 µM -0.794882806587638 0.254682396458514 no 2520 0.213340838250882 3751 6811119
SGTC_1807 st050092 58.9 µM -0.794973938769623 0.254653613588124 no 2521 0.213314331037218 3842 5008496
SGTC_8 0354-0001 70 µM -0.796133295895558 0.254287595023046 no 2522 0.212977281607302 3835 4993152
SGTC_728 3030-5151 22.5 µM -0.797592597561065 0.253827273874638 no 2523 0.212553474063757 3858 3125388
SGTC_1234 0326-0494 15.5 µM -0.799161637531797 0.253332825396008 no 2524 0.212098346542406 3894 1547813
SGTC_47 0149-0135 24.25 µM -0.799338820633907 0.253277021867407 no 2525 0.212046987311996 3855 5239155
SGTC_1274 0865-0114 173 µM -0.799826532950441 0.253123451054887 no 2526 0.211905654009068 3848 870624
SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 4.569 µM -0.800118188386288 0.253031638023995 no 2527 0.211821162024905 3874 3385 5-fluorouracil (5-FU) is a potent FDA-approved antitumor agent. 5-FU is a pyrimidine analog that inhibits thymidylate synthase and is metabolized into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_1656 st012921 11 µM -0.800982834950393 0.252759550587133 no 2528 0.211570791549697 3763 6732821
SGTC_1245 0418-0076 17.2 µM -0.801379118792259 0.252634899281148 no 2529 0.211456099958235 3890 6790114
SGTC_3240 9133527 49.47 µM -0.801541116540912 0.25258395212321 no 2530 0.211409225414798 3780 17617455
SGTC_2046 4110841 106 µM -0.801798814806356 0.252502918976975 no 2531 0.211334672175948 3863 44119630 YMR134W ERG29
SGTC_1050 3232-1156 69.3 µM -0.801938796973945 0.252458907366302 no 2532 0.211294181176413 3820 700529
SGTC_155 k072-0202 43.6 µM -0.802016220469567 0.252434566482512 no 2533 0.211271787742209 3753 5857737
SGTC_2697 mebhydrolin 72.4 µM -0.802606105641162 0.252249155302429 no 2534 0.211101219109435 3864 22530 H1 Histamine receptor antagonist. YIL048W NEO1
SGTC_1119 parthenolide 318.541 nM -0.803314247551665 0.252026668851939 no 2535 0.210896562510184 3974 5702252 Parthenolide specifically inhibits HDAC1 (histone deacetylase 1) without affecting other class I/II HDACs.
SGTC_2384 9036245 200 µM -0.805188933594436 0.251438173809224 no 2536 0.210355330746852 3811 6462766
SGTC_1483 3453-0561 55.9 µM -0.805602248176401 0.251308525284862 no 2537 0.210236114453072 3848 4546991
SGTC_1686 st019653 115.5 µM -0.806090260281574 0.251155491154142 no 2538 0.210095403531838 3803 97252
SGTC_330 1488-0319 80.1 µM -0.806803259923258 0.25093199255811 no 2539 0.209889920350322 3885 6846614
SGTC_1769 st044406 64.4 µM -0.807131716974611 0.250829069040239 no 2540 0.209795300310676 3839 670903
SGTC_2410 aloe-emodin-8-o-glycoside 46.3 µM -0.809783009051879 0.249999093516297 no 2541 0.20903244980082 3823 14077415 Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, culminating in apoptosis.
SGTC_3329 9141233 27.5565 µM -0.810003630519529 0.24993009465756 no 2542 0.208969044574743 3828 4909101 YNL103W MET4
SGTC_215 1287-0124 461.5 µM -0.810463573396878 0.249786281081387 no 2543 0.208836896308547 3866 5560863
SGTC_1736 st036774 51 µM -0.817237891895456 0.247673206341683 no 2544 0.206896246082971 3955 1272247
SGTC_184 1494-0393 24.714 µM -0.817379337060946 0.24762918812958 no 2545 0.206855840139094 3844 3090647
SGTC_2447 5741742 33.78 µM -0.818040990178087 0.247423334953598 no 2546 0.206666890989087 3898 1776504
SGTC_1316 1272-0050 65.9 µM -0.818049188360011 0.247420784913204 no 2547 0.206664550464713 3831 7340392
SGTC_3230 9131665 49.47 µM -0.818686133942669 0.247222706253125 no 2548 0.206482754884318 3780 15943720
SGTC_1191 1487-1166 10.6 µM -0.819207296235988 0.247060697217935 no 2549 0.20633407640779 3915 3955771
SGTC_1583 clindamycin 39.6 µM -0.819792714897709 0.246878781136746 no 2550 0.206167142397748 3824 32603 Cindamycin is an antibiotic that acts by inhibiting bacterial protein synthesis.
SGTC_1295 1013-0063 9.78 µM -0.822250484083859 0.246115823953214 no 2551 0.205467175857712 3836 6826038
SGTC_983 1491-0821 12.2 µM -0.822403680177755 0.246068309701007 no 2552 0.205423592764199 3874 46495113
SGTC_747 3448-8087 38.7 µM -0.822713982270053 0.245972083606667 no 2553 0.205335331064251 3896 5168703
SGTC_530 4358-1714 28 µM -0.824671193959133 0.245365608920567 no 2554 0.204779145043849 3919 1564641
SGTC_716 1683-5115 658 µM -0.825799292520152 0.245016414216615 no 2555 0.204458977750287 3848 723597
SGTC_1129 3453-1384 223 µM -0.826982594721253 0.244650419113293 no 2556 0.204123463397101 4014 1084452
SGTC_2329 6138490 200 µM -0.827441071644232 0.244508691477564 no 2557 0.203993554720694 4001 720019
SGTC_1405 3909-7894 12 µM -0.828254698688603 0.244257286251523 no 2558 0.20376313616045 3892 7104060
SGTC_325 2810-4341 181 µM -0.828293546354139 0.244245286073487 no 2559 0.203752138413363 3873 774970
SGTC_1221 2958-7315 257 µM -0.828768512077678 0.244098593222807 no 2560 0.203617704561397 3888 4562705
SGTC_175 3793-3120 23.7 µM -0.830758137702853 0.243484615402513 no 2561 0.203055137920527 3898 5322297
SGTC_758 0868-0029 16 µM -0.830788599568354 0.243475221675531 no 2562 0.203046532047661 3946 762687
SGTC_1951 sophoraflavanone G 9.2 µM -0.831381447639052 0.24329244018358 no 2563 0.20287908813161 3867 9910234 Sophoraflavanone G is a volatile phytoncide; a natural flavanone with antimicrobial activity.
SGTC_1334 1486-0610 236 µM -0.831857620834359 0.243145684545497 no 2564 0.202744657598555 3946 3742339
SGTC_2692 st077426 47.7 µM -0.833409183453111 0.24266782826851 no 2565 0.202306998589927 3881 25238571
SGTC_563 tetrahydrosecaminediol 614 µM -0.834072272774425 0.242463762632261 no 2566 0.202120129304428 3937 334274 A psychoactive constituent of the cannabis plant.
SGTC_1970 st070122 35.8 µM -0.834767878882095 0.242249789906268 no 2567 0.201924207310063 3895 102928
SGTC_2565 isoliquiritigenin 100 µM -0.834933032078655 0.242199002803754 no 2568 0.201877707541656 3964 638278 Binds to benzodiazepine receptor 65X better than valium.
SGTC_212 3807-4682 38.772 µM -0.835040247679688 0.242166035476972 no 2569 0.201847523846221 3965 3125501 YBL034C STU1
SGTC_853 0419-0306 21 µM -0.835914005461126 0.241897457664504 no 2570 0.201601641380047 3891 762713
SGTC_2910 7948405 25.97 µM -0.838663617017879 0.24105333074545 no 2571 0.200829050207515 3773 2971328
SGTC_566 0958-0068 16.5 µM -0.839281680030556 0.240863806984036 no 2572 0.200655630567159 3806 6815365
SGTC_1478 0453-0656 35.7 µM -0.839339783445916 0.240845994235908 no 2573 0.200639332204362 3903 5258496
SGTC_1882 5615643 20 µM -0.839357599439969 0.240840532535064 no 2574 0.200634334868464 3799 2253075
SGTC_2412 st077135 33.4 µM -0.84004792243111 0.240628957866521 no 2575 0.200440758773896 3996 13258915
SGTC_1990 st072050 59.8 µM -0.841704225150638 0.240121736331269 no 2576 0.199976766329965 3891 17233948
SGTC_109 0132-0036 33.701 µM -0.842053850410638 0.240014742609706 no 2577 0.199878905809594 3708 67274 A color developer.
SGTC_2004 4023728 41.89 µM -0.842506839214067 0.23987615583014 no 2578 0.199752156552233 3905 360084 YDR527W RBA50
SGTC_2573 2',4'-dihydroxychalcone 15.04 µM -0.843063545249442 0.239705897741692 no 2579 0.199596452771703 3891 5357218 A potent inhibitor of glutathione S-transferases. YPR085C ASA1
SGTC_3176 9106582 49.47 µM -0.84314859581244 0.239679892432116 no 2580 0.199572671616186 3817 17018027
SGTC_1634 st006576 41 µM -0.843164650678584 0.239674983621919 no 2581 0.19956818267476 3866 3915356
SGTC_991 3996-0057 64.7 µM -0.843678793047202 0.239517812492525 no 2582 0.199424460575029 3949 715343
SGTC_1894 3',6'-dihydroxyflavone 78.7 µM -0.844317160355658 0.23932274466423 no 2583 0.199246099678576 3898 688662
SGTC_1480 1070-0044 41.2 µM -0.844584055828468 0.239241214341392 no 2584 0.199171557125441 3904 3124987
SGTC_1204 4049-0315 18.3 µM -0.846948237391363 0.238519675204495 no 2585 0.198511986937852 4015 588402
SGTC_318 1488-0629 67.2 µM -0.848290499327964 0.238110552778939 no 2586 0.198138103669835 3954 3662576
SGTC_1658 st012944 20 µM -0.848384532249244 0.238081905896757 no 2587 0.19811192701063 3799 24207260
SGTC_1828 st055811 49 µM -0.849099507745996 0.237864152284957 no 2588 0.197912962150988 3940 5877589
SGTC_3224 9130643 49.47 µM -0.849736851522896 0.237670134369567 no 2589 0.197735702603004 3910 17644395
SGTC_1853 st056710 91.2 µM -0.850260657351032 0.23751074429584 no 2590 0.197590092345815 3989 269167
SGTC_2076 5212012 200 µM -0.851089141759688 0.237258762711182 no 2591 0.197359918336652 3808 604802
SGTC_467 ro 31-8220 72.8 µM -0.852378869927477 0.236866787297539 no 2592 0.197001921986258 3844 5083 Ro-318220 is a protein kinase C (PKC) inhibitor of the bisindolylmaleimide class. YBR109C | YER133W CMD1 | GLC7
SGTC_390 dec-rvkr-cmk 16.7 µM -0.854697214833988 0.236163089805567 no 2593 0.196359396412941 3954 9962075 A caspase and metalloprotease inhibitor. YBR109C CMD1
SGTC_2137 5261020 140 µM -0.854746621118418 0.236148105839575 no 2594 0.196345717378614 3873 763655
SGTC_780 0109-0199 192 µM -0.855117070082187 0.236035772553334 no 2595 0.196243170205257 3989 610414
SGTC_340 k038-0059 454 µM -0.855795511404541 0.235830121402499 no 2596 0.196055449223075 3899 23733424
SGTC_513 4245-1575 41.7 µM -0.856625973233536 0.235578523863083 no 2597 0.195825813323785 3837 719745
SGTC_2630 antimycin a 100 µM -0.857826882479336 0.235214957242997 no 2598 0.195494031654401 3887 5702199 Antimycin a is an antibiotic that inhibits complex III of the mitochondrial electron transport chain.
SGTC_2306 7482397 179.52 µM -0.858067588962768 0.235142122381644 no 2599 0.195427571471387 3910 891448
SGTC_1293 1000-1278 195 µM -0.858894670497447 0.234891952500983 no 2600 0.195199315012769 3958 678847
SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 66.67 µM -0.859414029690951 0.234734935551366 no 2601 0.195056066052607 3970 6708561
SGTC_1269 0831-0796 3.05 µM -0.859759887456941 0.234630405180115 no 2602 0.194960707482797 3961 927758
SGTC_504 lovastatin 124 µM -0.859811541893596 0.234614795603841 no 2603 0.19494646795394 3939 53232 Lovastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YNL163C RIA1
SGTC_3250 9135583 49.47 µM -0.860067208983737 0.234537543418711 no 2604 0.194875997764863 3939 7699353
SGTC_1454 4239-0054 42.6 µM -0.86023525774902 0.234486773588796 no 2605 0.194829686482953 4046 1340767
SGTC_1449 4112-4002 201 µM -0.861763389688371 0.234025383164946 no 2606 0.194408867472369 3978 2059539
SGTC_1219 1469-0211 33.1 µM -0.862164372535299 0.233904397348111 no 2607 0.19429853599672 3937 6822282
SGTC_35 0133-0054 64.071 µM -0.862417229017397 0.233828122508503 no 2608 0.19422898148288 3936 99677
SGTC_151 3013-0144 2.285 µM -0.863089395090092 0.233625428838957 no 2609 0.194044159101132 3859 906558 YHR107C CDC12
SGTC_2918 7977171 22.06 µM -0.864003313395404 0.233349990418646 no 2610 0.193793035189051 3844 2236483
SGTC_1002 4049-0206 172 µM -0.865327302123301 0.232951283989161 no 2611 0.193429584866307 3939 4662749
SGTC_2967 9089538 49.85 µM -0.866268625598174 0.232668043807826 no 2612 0.193171433723699 3971 728216
SGTC_938 3126-1755 342 µM -0.866343086961684 0.232645646876935 no 2613 0.193151022214285 3957 1777771
SGTC_2445 5742597 35.57 µM -0.867058856527987 0.232430414598255 no 2614 0.192954881083594 3894 1774255
SGTC_1969 st069479 40.1 µM -0.867243052096068 0.232375044817913 no 2615 0.192904425968006 3938 3895485
SGTC_1379 2144-0755 36.5 µM -0.868415954495053 0.2320226387497 no 2616 0.19258333191889 4013 5392327
SGTC_1546 5-methoxyflavanone 78.7 µM -0.869140996522011 0.231804944115515 no 2617 0.192385007719352 3914 147795
SGTC_3091 9116372 49.47 µM -0.870215421080558 0.231482556346693 no 2618 0.192091345009159 4016 17169793
SGTC_645 0845-0943 5.41 µM -0.870263773331404 0.231468053833612 no 2619 0.19207813578002 3931 1885106
SGTC_1905 st060207 84.5 µM -0.871335047751713 0.231146871544796 no 2620 0.191785619619649 3867 1948547
SGTC_2052 5265182 7.135 µM -0.871917881890609 0.230972234644 no 2621 0.191626588839983 3946 1239884
SGTC_2428 5615643 7.78 µM -0.87397629454672 0.230356054126199 no 2622 0.191065581760503 3976 2253075
SGTC_380 3970-0968 6 µM -0.873999391079075 0.23034914545722 no 2623 0.19105929266926 3838 2891601
SGTC_3175 9106517 49.47 µM -0.874538005584043 0.23018806714587 no 2624 0.190912666145903 3970 41468073
SGTC_2411 st077133 39.94 µM -0.874740036902287 0.230127663816454 no 2625 0.190857685156193 4044 1403142 YNL221C POP1
SGTC_2532 xanthone 78.9 µM -0.874756186324936 0.23012283584438 no 2626 0.190853290656729 3935 7020 An insecticide.
SGTC_2839 9003951 25.97 µM -0.875084091901074 0.230024818655292 no 2627 0.190764076072179 3982 2990634
SGTC_2075 5212009 200 µM -0.875113047104754 0.230016164519085 no 2628 0.190756199343711 3819 780898
SGTC_2682 pyrogallin 40.03 µM -0.876046485573951 0.229737275906041 no 2629 0.190502381580604 3948 822798 An ATP competetive kinase inhibitor.
SGTC_1955 wogonin 32.4 µM -0.876126722776501 0.229713311831609 no 2630 0.19048057340609 4029 5281703 A flavanone.
SGTC_1706 st031321 9.9705 µM -0.877139215135631 0.229411035739569 no 2631 0.190205513468665 3960 6103185
SGTC_3344 9148862 3.898 µM -0.877197035081661 0.229393780526373 no 2632 0.190189813113877 3987 4905352
SGTC_619 1652-1634 108 µM -0.878294395331393 0.229066433130784 no 2633 0.189891988286301 3907 5400454
SGTC_2198 6589944 200 µM -0.878427551462817 0.229026729905842 no 2634 0.189855869077375 3939 5290268
SGTC_48 0382-0018 55 µM -0.878883138104773 0.228890916633791 no 2635 0.189732321074372 3975 762596
SGTC_2568 diosmetin 100 µM -0.878885763284217 0.228890134182119 no 2636 0.189731609309899 3987 5281612 Diosmetin is a natural flavonoid and antioxidant that impedes human CYP1A enzyme activity.
SGTC_2295 7971645 200 µM -0.879976108177842 0.228565279670428 no 2637 0.189436126278585 4002 2978226 YKL099C UTP11
SGTC_2245 6637752 200 µM -0.881347302049653 0.228157117608371 no 2638 0.189064935555689 4017 681890
SGTC_2 0422-0095 29 µM -0.882102267666212 0.22793256271945 no 2639 0.18886075302121 3816 6790840
SGTC_1540 guanosine 70.6 µM -0.882622822381166 0.227777802810963 no 2640 0.188720046735683 3833 6802 Guanosine is a purine nucleoside
SGTC_1194 1488-0194 225 µM -0.882979858398254 0.22767169089421 no 2641 0.188623577030105 3905 1391452
SGTC_532 1548-0774 215 µM -0.883267491075156 0.227586226051803 no 2642 0.188545881945649 4099 5932993
SGTC_1149 3909-7961 23.3 µM -0.884212938084588 0.227305430904558 no 2643 0.188290637699004 3977 735261
SGTC_795 0685-0265 78 µM -0.88442148512865 0.227243519298455 no 2644 0.18823436454136 3979 302754
SGTC_2621 lithochol-11-enic acid 100 µM -0.885103718632955 0.227041050245403 no 2645 0.188050347013596 3869 6708711
SGTC_3252 9135871 49.47 µM -0.886299194445032 0.226686509701441 no 2646 0.187728161511503 3968 17682838
SGTC_2929 9013348 24.6 µM -0.886467135650115 0.226636728660816 no 2647 0.187682928016273 3979 2995952
SGTC_2287 7945887 168.79 µM -0.886549836065837 0.226612216916113 no 2648 0.187660655856722 3971 1245853
SGTC_204 PMA1.184 62.41 µM -0.887727933725766 0.226263200681546 no 2649 0.187343558128314 3978 2252213 YGL008C PMA1
SGTC_1673 st016611 27.3 µM -0.888327909489055 0.226085572189934 no 2650 0.187182195540872 3999 5226799
SGTC_3102 9121669 49.47 µM -0.888936539120421 0.225905462195008 no 2651 0.187018593357064 3963 41905072
SGTC_2094 5332512 191.667 µM -0.889557120620287 0.225721898885751 no 2652 0.18685186957512 3998 755774
SGTC_31 0508-1974 57.237 µM -0.890842786467789 0.225341877273352 no 2653 0.186506758781555 3909 6810525
SGTC_385 1494-0393 12.4 µM -0.891155949393896 0.225249366379078 no 2654 0.18642275640297 3953 3090647
SGTC_2013 4024628 200 µM -0.891538718482978 0.225136322472836 no 2655 0.186320114800011 3999 5230760
SGTC_3260 9137109 49.47 µM -0.891774940929433 0.225066574500215 no 2656 0.186256787947711 3878 17478346
SGTC_1520 flindersine 88 µM -0.893748929531514 0.224484205705481 no 2657 0.185728119785038 4099 68230 Flindersine is a natural alkaloid of the quinoline subtype.
SGTC_2969 9091408 28.7 µM -0.897202679238845 0.223467335515126 no 2658 0.18480538790786 3922 4286311
SGTC_1386 3228-0095 33.8 µM -0.897540294562201 0.223368073922417 no 2659 0.184715340991815 4000 870181
SGTC_2747 doxorubicin 7.63 µM -0.897555359087691 0.223363645416788 no 2660 0.184711323699627 3882 31703 Doxorubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally, doxorubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_256 clotrimazole 625 nM -0.897795133070508 0.223293165991151 no 2661 0.1846473899245 3893 2812 Clotrimazole, an imidazole antifungal; inhibits lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W | YJL195C CDC20 | YJL195C
SGTC_2395 5646831 180.19 µM -0.898022855560559 0.223226240714534 no 2662 0.184586682322805 3993 6808628
SGTC_2563 tomatine 8.54 µM -0.899455919030716 0.222805340337795 no 2663 0.184204932711519 3851 6708777 Tomatine is a toxic glycoalkaloid found in the stems and leaves of tomato plants with fungicidal properties.
SGTC_3258 9138477 49.47 µM -0.900557453446898 0.222482119897423 no 2664 0.183911832417709 4004 4970355
SGTC_915 methyl methanesulfonate (MMS) 110 mM -0.901225872241391 0.22228611790044 no 2665 0.183734118778889 4009 4156 MMS is a DNA alkylating agent; methylates DNA on N7-deoxyguanine and N3-deoxyadenine inducing DNA damage and stalling of replication forks.
SGTC_892 0929-0076 29 µM -0.904398725157875 0.221357079703337 no 2666 0.182892006964447 3958 5751038
SGTC_567 1080-0542 68.4 µM -0.905027397973615 0.221173262899783 no 2667 0.18272543631215 3854 5950415
SGTC_580 1123-0028 41 µM -0.905082931434236 0.221157029744328 no 2668 0.18271072694114 4035 1677248 YPR107C YTH1
SGTC_503 tyrphostin 8 294 µM -0.907200207256808 0.22053863100537 no 2669 0.182150467080174 3969 92970 A tyrosine kinase inhibitor. YOR207C RET1
SGTC_1530 rhein 70.4 µM -0.908026485222757 0.220297566704938 no 2670 0.181932114366909 4030 10168 An apoptosis inducer thought to act through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death.
SGTC_2275 7947463 200 µM -0.908828609218458 0.220063693837921 no 2671 0.181720301250006 3960 1225414
SGTC_1563 conessine 56.1 µM -0.909387426070148 0.219900845511368 no 2672 0.181572828331655 4045 441082 An anti-amoebic, histamine inhibitor.
SGTC_286 k060-0067 22.9 µM -0.909441009500198 0.219885234062116 no 2673 0.181558691490518 3976 5985051
SGTC_127 0180-0333 59.125 µM -0.910389436609275 0.219609016579383 no 2674 0.181308583311193 3867 771601
SGTC_1446 4239-0190 62 µM -0.911456195413112 0.219298574721854 no 2675 0.181027528011693 4003 1340085
SGTC_1835 st008666 49.2 µM -0.913098233412894 0.218821211759766 no 2676 0.180595439687238 3929 690455
SGTC_1619 st003326 88.7 µM -0.913845579738788 0.218604146075795 no 2677 0.180398996218124 3970 2849032
SGTC_2761 levamisole 97.89 µM -0.916980257254353 0.217695034928784 no 2678 0.179576492850742 3928 26879 An alkaline phosphatase inhibitor.
SGTC_2448 5185112 27.17 µM -0.917835309445969 0.217447434060854 no 2679 0.179352546738762 4024 5718189
SGTC_2620 irigenin 100 µM -0.919374239134234 0.217002209930713 no 2680 0.178949929419076 4053 5464170 A phytoestrogen derived from Belamcanda chinensis with an antiproliferative effect on prostate cancer cells in vitro.
SGTC_2288 7946289 167.31 µM -0.920512177975611 0.216673334598416 no 2681 0.178652586055881 4056 1246052
SGTC_396 dithiazanine 1.25 µM -0.920889896221014 0.216564234130488 no 2682 0.17855395710863 3990 10578 An antihelmenthic.
SGTC_1891 st059073 26.2 µM -0.92195754353853 0.216256025878745 no 2683 0.178275360925302 4087 688754
SGTC_68 0986-0284 82.829 µM -0.922768749539732 0.216022016940282 no 2684 0.178063864815193 4087 423278 YIL048W NEO1
SGTC_822 1487-0950 154 µM -0.924561619468434 0.215505347667816 no 2685 0.177596992554931 4027 1958375
SGTC_171 k064-0041 9.68 µM -0.929987895439763 0.21394597765277 no 2686 0.176188675898068 4022 53325
SGTC_1418 3966-3099 2.4 µM -0.931082160696411 0.21363231217708 no 2687 0.175905532872859 3997 740335
SGTC_2791 5663188 71.43 µM -0.933664097941708 0.212893275973824 no 2688 0.175238595017777 4055 54690634
SGTC_3262 9137218 49.47 µM -0.934682393507555 0.212602216730552 no 2689 0.174976001538681 3834 17650664
SGTC_1799 st045822 46.1415 µM -0.936279096588105 0.212146299568986 no 2690 0.17456475390462 3982 3674992
SGTC_2292 7671323 168.05 µM -0.937289316133696 0.211858140390256 no 2691 0.174304878554087 4074 937504
SGTC_2674 ligustilide 100 µM -0.938463461834555 0.211523510153797 no 2692 0.1740031428451 4071 5319022 A signalling regulator.
SGTC_635 k038-0028 24.7 µM -0.938482296106877 0.211518144929966 no 2693 0.173998305461479 4016 4035102
SGTC_2862 9027634 71.43 µM -0.938543049330284 0.211500839009766 no 2694 0.17398270222141 3950 5012562
SGTC_2413 inermin 26.06 µM -0.939090138013423 0.211345034868719 no 2695 0.173842233606456 4127 91510 Inermin is a bioactive isoflavanoid. YFL038C YPT1
SGTC_935 2996-0153 430 µM -0.939348739883052 0.211271411636928 no 2696 0.173775860988892 4044 23738523
SGTC_1054 3429-0080 167 µM -0.939973824273055 0.211093513919197 no 2697 0.173615493743788 4074 1162877
SGTC_1784 st039334 36.3 µM -0.94110563342245 0.210771626883036 no 2698 0.173325364463287 4103 3496984
SGTC_1672 st016598 6.51 µM -0.942271142444413 0.210440456658766 no 2699 0.173026919317511 4057 4665860 YNL267W PIK1
SGTC_1831 st055328 12 µM -0.942530109402261 0.210366914728539 no 2700 0.172960651625774 4025 1103068
SGTC_2466 5983409 37.09 µM -0.942634061998463 0.210337398316723 no 2701 0.172934055489242 4031 2879657
SGTC_945 3381-0768 11.3 µM -0.943259810755876 0.210159773922461 no 2702 0.172774013542642 4079 1126236 YIL048W NEO1
SGTC_2569 tetrandrine 100 µM -0.943785764957502 0.210010545280918 no 2703 0.172639568168044 4033 73078 Tetrandrine a bis-benzylisoquinoline alkaloid, a calcium channel blocker.
SGTC_1031 k035-0009 16 µM -0.945722691399005 0.209461519532413 no 2704 0.172145022815213 4097 5180959
SGTC_407 eburnamonine 100 µM -0.946283651307459 0.209302672139496 no 2705 0.172001964849344 3881 3195
SGTC_3123 9126162 49.47 µM -0.948383898432103 0.208708573743967 no 2706 0.171467026715449 4096 25239884
SGTC_29 0299-0004 12.984 µM -0.948644818013858 0.20863483670612 no 2707 0.171400644182319 3924 16871 A napthoquinone isolated from Swertia calycina.
SGTC_153 4077-0274 519.67 µM -0.950144581224752 0.208211294850086 no 2708 0.171019396661572 4024 3121976
SGTC_858 0438-0351 2.77 µM -0.951973898363213 0.207695372465529 no 2709 0.170555109779035 4005 2799119
SGTC_2345 9052315 157.45 µM -0.952156516374239 0.207643910193565 no 2710 0.170508805054998 4078 6469265
SGTC_1300 1094-0077 113 µM -0.955725914805426 0.206639557194318 no 2711 0.169605363110695 4001 5532636
SGTC_1708 st033234 31.827 µM -0.958951501627962 0.20573442488072 no 2712 0.168791588934555 4134 674664
SGTC_1747 st037496 66.6 µM -0.960033976644414 0.205431199512431 no 2713 0.168519057575982 4038 723305
SGTC_1893 st059353 36.1 µM -0.960054476242512 0.205425459680153 no 2714 0.168513899187148 4046 3112488
SGTC_2646 retinol 96.75 µM -0.960102461357019 0.205412024349677 no 2715 0.168501824914252 4058 445354 A vitamin A analog and teratogen.
SGTC_2374 9071832 200 µM -0.961062234151125 0.205143407619962 no 2716 0.168260438549249 3949 17381698
SGTC_1314 1222-0010 41.1 µM -0.962104203816472 0.204852022465879 no 2717 0.167998631329665 4048 3526027
SGTC_792 4534-1957 155 µM -0.962698552932043 0.204685923973677 no 2718 0.167849411566107 3985 1717904
SGTC_2179 6298986 200 µM -0.964416994920256 0.204206134194883 no 2719 0.167418452545993 4029 738374
SGTC_1626 st003712 1.76 µM -0.967133496848668 0.203449053305199 no 2720 0.166738651069503 4088 24207035
SGTC_350 k064-0020 19.8 µM -0.967654744803352 0.203303974781573 no 2721 0.166608413319959 4077 2790705
SGTC_2982 9019404 25.97 µM -0.968467274486338 0.203077947215746 no 2722 0.166405527602505 3992 22333232
SGTC_3232 9132874 49.47 µM -0.968796117698853 0.202986513062009 no 2723 0.166323462007657 4010 3784940
SGTC_2402 5553605 200 µM -0.970674764807889 0.202464630829937 no 2724 0.165855131050718 4152 6758546
SGTC_998 3996-0085 177 µM -0.9707860918717 0.2024337297227 no 2725 0.165827404926698 4078 715391
SGTC_2701 st077767 14.721 µM -0.97195516067681 0.202109401056315 no 2726 0.165536428040653 4029 5721188
SGTC_3048 9093155 49.47 µM -0.973273725941052 0.20174397172919 no 2727 0.165208638571934 4019 25236002
SGTC_1186 1319-0216 26 µM -0.973554014866617 0.201666343026516 no 2728 0.16513901416827 4120 4565136
SGTC_664 1222-0054 14.9 µM -0.974716301191522 0.201344627672535 no 2729 0.164850502328289 4028 6813991
SGTC_1748 st037455 53.6035 µM -0.979653861472016 0.199981367437902 no 2730 0.163628504091029 4113 580690
SGTC_2314 7727897 200 µM -0.979811676486553 0.199937886443388 no 2731 0.163589543647206 4076 900724
SGTC_3012 9080433 71.4286 µM -0.981287760776296 0.199531472869698 no 2732 0.163225428302556 4055 17688859
SGTC_2823 7987624 58.44 µM -0.986035357066992 0.198227682014234 no 2733 0.162057881437646 4081 2239440
SGTC_3353 9151644 39.2805 µM -0.986301715973974 0.198154686870373 no 2734 0.161992538984539 4111 4909158
SGTC_2024 5144227 134 µM -0.987618724438061 0.197794001799435 no 2735 0.161669706244855 4136 3475211
SGTC_3089 9117425 49.47 µM -0.990379718417203 0.197039145484941 no 2736 0.160994277436303 4083 9401657
SGTC_2114 5491910 81.25 µM -0.990866998501957 0.196906104254288 no 2737 0.160875264377146 4139 2849228
SGTC_2479 5617353 43.85 µM -0.991092197277695 0.196844637005067 no 2738 0.160820281344243 4134 2731746
SGTC_2220 6782180 200 µM -0.997560772646083 0.195084024656038 no 2739 0.159246195383185 3995 833803
SGTC_2805 7950783 58.44 µM -0.998210745076157 0.194907646406233 no 2740 0.159088588568075 4101 1178958 YDL195W SEC31
SGTC_2233 sulbentine 40.3845 µM -0.999201774673716 0.194638904694863 no 2741 0.158848478179457 4073 67686 An antifungal agent of unknown mechanism. YOR207C | YLR033W RET1 | RSC58
SGTC_3283 9109332 35.8195 µM -1.00000395589389 0.19442153899877 no 2742 0.15865429672284 3921 17027281
SGTC_1758 st042942 75.2445 µM -1.00054582034016 0.194274794558445 no 2743 0.15852321743223 4023 669317
SGTC_1473 k844-0725 134 µM -1.00132782287676 0.194063136322013 no 2744 0.15833417297881 4154 54682906
SGTC_1420 4'-methoxyflavone 42 µM -1.00494891663856 0.193084877180527 no 2745 0.157460724121135 4079 77793 From seeds of Psoralea corylifolia (Fabaceae) YLR208W SEC13
SGTC_449 xestospongin c 11.1929 µM -1.00611582260999 0.192770273441435 no 2746 0.157179929125443 4114 5311502 Synthetic form of the macrocyclic bis-1-oxaquinolizidine isolated from the Okanowan marine sponge. YIL048W NEO1
SGTC_1814 st052110 31.539 µM -1.00690752840079 0.192557003995306 no 2747 0.156989606923197 4047 674163
SGTC_2772 vinpocetine 57.06 µM -1.00795660543201 0.192274626243036 no 2748 0.156737647558966 4135 443955 Ca2+-calmodulin-dependent phosphodiesterase I (PDE1) inhibitor.
SGTC_455 paf C-16 10 µM -1.00883051493711 0.192039591425279 no 2749 0.156527961907714 4076 108156 Platelet-activating factor, also known as a PAF; natural lipid; potentphospholipid activator and mediator of lipid signaling processes, including platelet aggregation and degranulation, inflammation and andanaphylaxis.
SGTC_977 1348-1378 135 µM -1.00904496158485 0.191981943646712 no 2750 0.156476535862213 4081 X977
SGTC_2254 7938975 95.19 µM -1.0091865002646 0.191943900869228 no 2751 0.156442599834227 4183 2969277
SGTC_615 k087-0205 167 µM -1.00958104805295 0.191837878644124 no 2752 0.156348026653447 4099 9642773
SGTC_1616 st002734 56.1 µM -1.0098942232024 0.191753748268253 no 2753 0.156272985322773 4045 4026101
SGTC_597 k018-0003 82.8 µM -1.01169812309564 0.191269594319174 no 2754 0.155841206606808 4160 6786234
SGTC_1116 jasmonic acid 1.58368 µM -1.01181261330333 0.191238891267778 no 2755 0.155813828975587 4165 5281166 Jasmonic acid (JA) is a plant hormone derived from the fatty acid linolenic acid.
SGTC_2381 9035592 200 µM -1.01203254092598 0.191179921345836 no 2756 0.155761247371831 4098 4749657
SGTC_2468 5987765 72.9 µM -1.01212296241884 0.191155679565838 no 2757 0.155739632258286 4145 26772094
SGTC_1066 ketoconazole 628 nM -1.01528764434013 0.190308423799356 no 2758 0.154984366195671 4166 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YBR102C | YOR262W | YPR112C | YDR280W | YMR079W | YDL163W EXO84 | GPN2 | MRD1 | RRP45 | SEC14 | YDL163W
SGTC_2362 9071156 126 µM -1.0168042876521 0.189903203551029 no 2759 0.154623271011426 4141 653133
SGTC_3304 9125678 46.087 µM -1.01707920074416 0.189829808471385 no 2760 0.154557876964404 4040 41316246 YGL155W | YKL019W | YKL058W CDC43 | RAM2 | TOA2
SGTC_1009 4106-0057 9.87 µM -1.01819421895604 0.189532304724959 no 2761 0.154292833123599 4118 2928005
SGTC_500 h-89 112 µM -1.01897912838634 0.189323051154634 no 2762 0.154106437691212 4138 449241 Protein kinase A inhibitor; also known to inhibit several other kinases.
SGTC_3292 9120825 59.784 µM -1.01909657455281 0.189291752734298 no 2763 0.15407856012 4116 24824900
SGTC_442 cape 100 µM -1.02093904837436 0.188801165917324 no 2764 0.153641658641285 4092 5281787
SGTC_3062 9077494 49.47 µM -1.02234287640358 0.188427901696502 no 2765 0.153309323329947 4094 16459633
SGTC_607 4491-0986 66.8 µM -1.02262587426012 0.1883527104797 no 2766 0.153242385542558 4137 698981 YDR232W HEM1
SGTC_2610 ononetin 44.17 µM -1.02342326764776 0.188140946326411 no 2767 0.153053881401681 4112 259632
SGTC_131 0141-0277 33.849 µM -1.02409516892283 0.18796262329017 no 2768 0.152895163024858 4085 1547771
SGTC_882 0843-0131 351 µM -1.02428639593456 0.187911890598097 no 2769 0.152850010809159 4113 5425421
SGTC_534 k292-0788 63.4 µM -1.02606422744207 0.187440635145061 no 2770 0.152430655350597 4166 4146317
SGTC_3183 9108214 49.47 µM -1.02625794544683 0.187389329867625 no 2771 0.152385007263748 4041 4974831
SGTC_3264 9137442 49.47 µM -1.0293579991348 0.186569477004363 no 2772 0.151655739049991 4127 17015726
SGTC_2401 5128683 200 µM -1.02995072290001 0.186412976170981 no 2773 0.151516569095475 4117 708373
SGTC_1895 st058434 18.3 µM -1.03054960492245 0.186254931949084 no 2774 0.151376039460899 4143 5393175
SGTC_1719 st032227 49.2 µM -1.03281537142884 0.185657750600686 no 2775 0.150845154423119 4131 3125804
SGTC_1114 scopoletin 1.73284 µM -1.03289632524966 0.185636435846754 no 2776 0.15082620933409 4160 5280460 A coumarin with genotoxic properties.
SGTC_1861 st057647 17.4 µM -1.03305612739995 0.185594365161731 no 2777 0.150788816540011 4201 688668
SGTC_3080 9117754 49.47 µM -1.03308055927839 0.185587933567853 no 2778 0.150783100163436 4157 9550191
SGTC_24 0417-1663 219 µM -1.03765746177179 0.18438552299334 no 2779 0.149714777842655 4147 4329390
SGTC_1018 4259-0013 28.1 µM -1.03958617215477 0.183880281013714 no 2780 0.149266101986601 4192 6801262
SGTC_1812 st052057 4.327 µM -1.03966160337296 0.183860538704753 no 2781 0.149248572686427 4147 3645418
SGTC_542 3381-0244 89.3 µM -1.04075239158905 0.183575198689697 no 2782 0.148995240397999 4151 1112843
SGTC_99 0109-0120 622.8 µM -1.04618487058202 0.182158226269468 no 2783 0.147737843348803 4114 759414
SGTC_1312 1218-2183 165 µM -1.04744737135113 0.181829905405435 no 2784 0.147446646571896 4182 6744073
SGTC_2501 sodium tetradecyl sulfate 13.37 µM -1.04894896011966 0.181439890548943 no 2785 0.147100805000408 4187 23665772 A membrane-active detergent.
SGTC_1909 st060837 51.5 µM -1.04907725893193 0.181406591184982 no 2786 0.147071280831026 4124 678937
SGTC_2905 7799065 20.05 µM -1.04989892796347 0.181193421511305 no 2787 0.146882292264916 4056 1296806
SGTC_1 0258-0098 57.368 µM -1.05172061765239 0.180721371320854 no 2788 0.146463874386715 4099 6790032 YDR047W HEM12
SGTC_336 4111-0029 111 µM -1.05413772784609 0.180096222662327 no 2789 0.145909932633509 4145 3131175
SGTC_1637 st007924 17.4 µM -1.05493532140721 0.17989023551886 no 2790 0.145727453291037 4074 683336
SGTC_1282 0886-0010 32.4 µM -1.05740632611968 0.179253011713631 no 2791 0.145163092806226 4204 2836211 YNL267W PIK1
SGTC_2248 tofa 1.1 µM -1.06191595096069 0.178093732320667 no 2792 0.144136921525702 4125 115175 TOFA (5-(Tetradecyloxy)-2-furoic acid) is a cell-permeable, potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner
SGTC_2704 st078022 71.1 µM -1.06222991451743 0.178013198766088 no 2793 0.144065661257212 4212 54697681
SGTC_3060 1327-0027 12.5 µM -1.06237573765181 0.177975802059003 no 2794 0.144032571880065 4055 16000455 YPR107C YTH1
SGTC_3101 9120531 49.47 µM -1.06391866005308 0.177580419315217 no 2795 0.143682774505583 4190 24824904
SGTC_1123 mangostin 811.285 nM -1.06397572298539 0.177565807248119 no 2796 0.143669848717553 4164 5281650 An antioxidant.
SGTC_3168 9103419 49.47 µM -1.0672346771955 0.176732548457238 no 2797 0.142932938595268 4158 16649256
SGTC_363 0455-0021 3.06 µM -1.06898087830298 0.176287093572608 no 2798 0.142539142880717 4122 4597466
SGTC_861 0443-0273 110 µM -1.06941534780946 0.176176371128551 no 2799 0.142441277298515 4161 6149169
SGTC_172 1112-0046 2.638 µM -1.06950545829672 0.176153412420872 no 2800 0.142420985328468 4149 2802135 YIL048W NEO1
SGTC_1904 st060225 78 µM -1.06980213014355 0.176077838571843 no 2801 0.142354191647305 4087 66595
SGTC_1796 st049173 110.4 µM -1.06999951315733 0.176027568820182 no 2802 0.142309763924748 4123 94134
SGTC_1691 st019933 84.6 µM -1.0709677205708 0.175781116173504 no 2803 0.142091971981141 4155 6176082
SGTC_1911 st060208 74.3 µM -1.07235491259313 0.175428394090324 no 2804 0.141780325539599 4209 688783
SGTC_1756 st041558 35.5 µM -1.07285181477386 0.175302155716978 no 2805 0.141668804232498 4255 3955792
SGTC_3007 9078383 71.4286 µM -1.07288370081898 0.175294057010382 no 2806 0.14166164997731 4155 6496995
SGTC_519 k048-0011 62.8 µM -1.0739115056135 0.175033132919594 no 2807 0.141431173039262 4209 6836379
SGTC_556 4058-0063 51.5 µM -1.07808658250717 0.173975760434261 no 2808 0.140497559423757 4206 6615692
SGTC_458 nppb 133 µM -1.08086734140252 0.173273768585855 no 2809 0.139878063935777 4217 4549 A chloride channel blocker.
SGTC_1310 1188-0297 994 nM -1.08238446445287 0.172891538226831 no 2810 0.139540864256 4046 1588352
SGTC_2492 derrusnin 100 µM -1.08359793029166 0.172586199596623 no 2811 0.139271554457452 4168 1715307 Part of coumarin class of compounds.
SGTC_2462 5162487 171.77 µM -1.08458270270409 0.172338658911093 no 2812 0.13905325972622 4087 2259986
SGTC_1666 st014829 29 µM -1.09012090512374 0.170950751425233 no 2813 0.137829944340526 4158 3858230
SGTC_520 3584-0023 682 µM -1.09410086877781 0.169957776709009 no 2814 0.136955370729958 4192 1340790
SGTC_894 0960-0238 55.9 µM -1.09528862083968 0.169662158202125 no 2815 0.136695105568703 4183 6741907 YDL195W SEC31
SGTC_3049 9092223 49.47 µM -1.0967434844213 0.169300508263732 no 2816 0.136376770880604 4170 8623917
SGTC_2493 resveratrol 26.09 µM -1.09757814798456 0.169093251174205 no 2817 0.136194369568748 4123 6255462 Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates SIRT1, a NAD+-dependent histone deacetylase.
SGTC_2736 butenafine 14.65 µM -1.10018796243262 0.168446254328323 no 2818 0.135625117154366 4114 2484 Butenafine inhibits squalene epoxidase, an enzyme in the ergosterol biosynthetic pathway. Because ergosterol is part of the fungal cell membrane butenafine is thought to change cell membrane permeability, ultimately resulting in fungal cell lysis. YGR175C ERG1
SGTC_1347 1493-0251 600 nM -1.10117366413341 0.168202304574051 no 2819 0.135410540696212 4244 3986378
SGTC_3100 9120536 49.47 µM -1.10383638818334 0.167544448141468 no 2820 0.134832058470835 4041 16421196
SGTC_2269 7935389 174.42 µM -1.10424726623493 0.167443083830198 no 2821 0.134742945602551 4166 97605
SGTC_2849 9019321 12.99 µM -1.10646887243605 0.166895694413295 no 2822 0.134261814878399 4229 16489627
SGTC_150 3970-0969 77.2 µM -1.10736984507858 0.166674029927341 no 2823 0.134067028953457 4285 6615640
SGTC_1172 0370-0043 85 µM -1.10833822515399 0.166435993266561 no 2824 0.133857886452117 4227 376585
SGTC_2193 5925765 200 µM -1.11045134852801 0.165917330686066 no 2825 0.13340229087797 4199 877370
SGTC_1163 k060-0048 49.9 µM -1.11171235017279 0.16560831817991 no 2826 0.133130924003775 4190 6809982
SGTC_907 3448-6986 75.5 µM -1.11303779413218 0.165283915349874 no 2827 0.132846098968739 4246 590582
SGTC_2390 9097792 176.6 µM -1.11403026050764 0.165041278310711 no 2828 0.132633102498271 4228 4497149
SGTC_218 alverine citrate 93.75 µM -1.11415509674175 0.165010774827794 no 2829 0.132606327649454 4245 21718 An antispasmotic used to treat irritable bowel syndrome.
SGTC_471 1-acyl-paf 4 µM -1.11574513108507 0.164622572503474 no 2830 0.132265623157625 4137 16759367
SGTC_970 1315-0089 19.5 µM -1.11584197866684 0.164598946579917 no 2831 0.132244890662979 4159 6811083 YLR033W RSC58
SGTC_990 3985-0011 41.3 µM -1.11640432921163 0.16446180484222 no 2832 0.132124550620442 4187 5399565 YGL099W LSG1
SGTC_2513 baicalein 25.65 µM -1.11741150104574 0.164216368670149 no 2833 0.131909209936686 4224 5281605 Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis; inhibits cellular Ca2+ uptake; may also act as an iron chelator. YIL026C | YBR002C IRR1 | RER2
SGTC_2310 7668677 200 µM -1.11791875092609 0.164092847705954 no 2834 0.131800847928958 4224 2197143
SGTC_1143 3454-2408 5.08 µM -1.1207180747544 0.163412265704693 no 2835 0.131203942988615 4214 X1143
SGTC_559 1550-0661 158 µM -1.12529381074409 0.162303749561696 no 2836 0.130232275789858 4274 5830875
SGTC_2840 9008771 71.43 µM -1.12934828985284 0.161325613055119 no 2837 0.129375468712897 4168 2992978
SGTC_30 5-(2-thienylidene)-Rhodanine 28.7 µM -1.12935331080713 0.161324404146599 no 2838 0.129374410094284 4152 1241132 A phosphatase inhibitor.
SGTC_431 k089-0097 107 µM -1.13254059620521 0.160558185370179 no 2839 0.128703613508483 4023 5499420
SGTC_2657 nystatin 74.44 µM -1.13334234063642 0.160365821986164 no 2840 0.128535258788538 4251 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_3064 1327-0027 10 µM -1.13503655067711 0.159959823985115 no 2841 0.128180002129941 4143 16000455 YPR107C YTH1
SGTC_1730 st033808 45.1 µM -1.13609827421109 0.159705737052678 no 2842 0.127957718617895 4160 1045166
SGTC_1742 st038235 28.8875 µM -1.14164664037858 0.158382225289203 no 2843 0.126800464440155 4284 564103 YBR002C RER2
SGTC_1716 st033144 30.6155 µM -1.14205763486438 0.158284473394495 no 2844 0.126715031809937 4258 674617
SGTC_3153 9100258 49.47 µM -1.14245191423591 0.158190734274394 no 2845 0.126633111396623 4171 25236848
SGTC_2789 5281112 71.43 µM -1.14251695467505 0.15817527454342 no 2846 0.1266196013265 4253 765948
SGTC_2843 9000894 45.46 µM -1.14437162516234 0.157734847538895 no 2847 0.126234775276823 4162 2242070
SGTC_1279 0874-0590 65.2 µM -1.14477559091818 0.157639025075637 no 2848 0.126151064543208 4294 3523074
SGTC_1584 6-fluoro-dl-tryptophan 90 µM -1.14574278566033 0.157409757637311 no 2849 0.125950797430725 4260 94937 An inhibitor of serotonin biosynthesis.
SGTC_2584 androsterone 48.74 µM -1.14581958061534 0.157391563271998 no 2850 0.125934905791199 4168 2754130 A steroid.
SGTC_439 amiodarone 34.4 µM -1.14670609493383 0.157181629180247 no 2851 0.1257515553121 4096 2157 Amiodarone is a non-selective ion channel blocker with broad fungicidal activity. Amiodarone induces an immediate influx of Ca2+ inSaccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. YIL048W | YNL267W NEO1 | PIK1
SGTC_112 phenothiazine 287.218 µM -1.14953241204101 0.1565135632152 no 2852 0.125168254847573 4203 7108 Phenothiazine is an organic compound that occurs in various antipsychotic and antihistaminic drugs.
SGTC_2219 9098279 200 µM -1.1504867717433 0.156288400899317 no 2853 0.124971719736997 4178 902349
SGTC_2341 7987486 176.74 µM -1.15319241155566 0.155651219146321 no 2854 0.124415708760006 4275 1258686
SGTC_841 0251-0215 91.2 µM -1.15339466757437 0.155603656509452 no 2855 0.124374214596148 4284 3888614
SGTC_262 fenpropimorph 62.5 µM -1.15348971141261 0.1555813092593 no 2856 0.124354719065046 4231 91695 Fenpropimorph is a morpholine antifungal drug that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in fungal cytoplasmic cell membranes. YDL196W YDL196W
SGTC_546 peri-Naphthalide 147 µM -1.15486866672476 0.15525731959463 no 2857 0.124072106151654 4174 223824 A penicillin ester.
SGTC_217 ketoconazole 989 nM -1.15520429123419 0.155178531047677 no 2858 0.124003388930607 4073 456201 Ketoconazole is an imidazole antifungal; acts by inhibiting lanosterol 14α-demethylase preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YOR174W MED4
SGTC_2870 9038528 12.99 µM -1.15543800248758 0.155123682440078 no 2859 0.123955553605531 4290 6463316
SGTC_1601 4'-hydroxyflavanone 55.5 µM -1.15754207662576 0.154630463439096 no 2860 0.123525479413563 4311 165506
SGTC_1064 honokiol 6.76 µM -1.15854076196961 0.154396723272627 no 2861 0.12332171361777 4267 72303 Inhibits phosporylation of AKT, SRC Kinases and induces apoptosis.
SGTC_2933 9026794 32.47 µM -1.16012843222194 0.15402561356778 no 2862 0.122998259873166 4195 17586027
SGTC_1181 1222-0449 220 µM -1.16691843659455 0.152445149326259 no 2863 0.121621654848874 4316 658318
SGTC_784 4579-0127 173 µM -1.1724873391833 0.151156974183944 no 2864 0.120500726155336 4281 1948547
SGTC_1047 2043-3044 82 µM -1.17346203312428 0.150932258939474 no 2865 0.120305286788058 4242 669592
SGTC_2454 5-benzylidenerhodanine 10.36 µM -1.1752607029257 0.150518160473198 no 2866 0.119945215556245 4319 1273210
SGTC_3319 9138450 16.7555 µM -1.17813804158083 0.149857300697124 no 2867 0.119370789165843 4205 2029690
SGTC_485 niflumic acid 177 µM -1.1783143133323 0.149816878057893 no 2868 0.119335661822094 4313 4488 A COX2 inhibitor.
SGTC_2832 7992762 51.95 µM -1.17950634420618 0.149543712430488 no 2869 0.119098305980498 4206 2985177
SGTC_1323 1348-1351 11.2 µM -1.18102960490562 0.149195126280936 no 2870 0.118795481376835 4238 6989654
SGTC_661 1304-0007 33.6 µM -1.18106037907696 0.149188089452099 no 2871 0.118789369074139 4264 3117130
SGTC_1524 corynanthine 62.1 µM -1.18413558097383 0.148486030731163 no 2872 0.118179698683292 4365 18528820 Corynanthine acts as an α1-adrenergic and α2-adrenergic receptor antagonist.
SGTC_3103 9120822 49.47 µM -1.18511073734067 0.148263867772734 no 2873 0.117986833135502 4274 17141819
SGTC_3069 9117009 49.47 µM -1.18535655969682 0.148207898920911 no 2874 0.117938249769324 4249 41904981
SGTC_1289 0976-0073 69.1 µM -1.18901324851166 0.147377012905162 no 2875 0.117217226782861 4340 3391136
SGTC_1167 k781-0610 148 µM -1.189605381964 0.14724276044333 no 2876 0.117100764765931 4302 4525169
SGTC_692 k241-0027 77.8 µM -1.19035538103734 0.147072833336478 no 2877 0.116953371131468 4333 3600480
SGTC_1373 2887-0003 58.5 µM -1.1935127297845 0.146358915998346 no 2878 0.116334314847579 4234 776948
SGTC_895 0964-0006 13.7 µM -1.19731836690911 0.145501509650778 no 2879 0.1155912440997 4274 6738897
SGTC_443 clozapine 122 µM -1.19765668846454 0.14542544996797 no 2880 0.115525348605225 4247 2818 An adrenergic, cholinergic, GABAA and histaminergic receptor agonist. YIL048W NEO1
SGTC_558 k064-0027 21.3 µM -1.19842570024727 0.145252664254742 no 2881 0.11537566610025 4287 5088526
SGTC_420 mitomycin C 81.9 mM -1.19880932809198 0.14516652034381 no 2882 0.115301047304809 4268 5746 Mitomycin is a bifunctional and trifunctional alkylating agent, cross-links DNA inhibiting DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific.
SGTC_1035 k081-0041 55.2 µM -1.20247858700867 0.144344322704602 no 2883 0.114589078747971 4311 731709
SGTC_1924 st058459 75.1 µM -1.20274863802528 0.144283934646772 no 2884 0.114536802997092 4230 688683
SGTC_1489 4065-0444 182 µM -1.20616091202832 0.143522358505564 no 2885 0.113877726081046 4294 2877968
SGTC_497 capsazepine 133 µM -1.2083014780956 0.1430459988916 no 2886 0.113465660066738 4246 2733484 A calcium channel blocker.
SGTC_730 1436-0052 41.2 µM -1.2090173768807 0.142886922078057 no 2887 0.113328084758124 4324 768764 YPL266W | YMR113W | YOL144W | YBR192W DIM1 | FOL3 | NOP8 | RIM2
SGTC_1510 1123-0200 71.5 µM -1.21329127273273 0.141939725914761 no 2888 0.11250923920137 4316 5378812 YNL149C | YNL150W PGA2 | YNL150W
SGTC_1032 k061-1018 98.7 µM -1.21345968920335 0.141902488115555 no 2889 0.112477058680035 4363 4005393
SGTC_1049 3226-0134 66 µM -1.21390758985703 0.141803487031808 no 2890 0.112391507145715 4325 5702385
SGTC_2130 NSC 7 2.4545 µM -1.21895567605961 0.140690924976525 no 2891 0.111430508021184 4371 21448
SGTC_2938 9059746 27.26 µM -1.22025199985007 0.140406183009763 no 2892 0.111184679942574 4296 6471769
SGTC_3313 9133968 57.047 µM -1.22108233626033 0.140224002498059 no 2893 0.111027423440161 4292 1494643
SGTC_3318 9139014 38.6185 µM -1.22176486753184 0.140074371554362 no 2894 0.110898278929663 4302 16643984
SGTC_2716 st080858 38.6235 µM -1.22274657205835 0.13985934332072 no 2895 0.11071271539322 4272 5296050
SGTC_2165 5727197 32.143 µM -1.22342304354283 0.13971130262151 no 2896 0.110584977104956 4403 1361712
SGTC_216 k038-0035 28.382 µM -1.22465665104058 0.139441611265778 no 2897 0.110352306717651 4220 4444231 YPR107C YTH1
SGTC_3170 9103054 49.47 µM -1.22512863343218 0.139338520168523 no 2898 0.110263379153012 4281 16432970
SGTC_2251 lansoprazole 556 µM -1.22707016038788 0.138914994422802 no 2899 0.109898111013262 4248 3883 Gastric proton pump inhibitor. YBR192W RIM2
SGTC_2880 9042983 58.44 µM -1.22821261499608 0.1386661888092 no 2900 0.10968358216979 4271 6464714
SGTC_3106 9121286 49.47 µM -1.23264459725798 0.137703858716621 no 2901 0.108854195200911 4272 15943471
SGTC_462 ag-879 158 µM -1.23573503353491 0.137035525894293 no 2902 0.108278535335597 4340 6809654 Ag-879 is a 5-Lipoxygenase inhibitor.
SGTC_2111 5486399 200 µM -1.2377600178426 0.136598809854091 no 2903 0.107902528784508 4264 689674
SGTC_1740 st038286 13.222 µM -1.23790123970711 0.136568388935334 no 2904 0.107876341308139 4344 716786
SGTC_2028 5153890 36.43 µM -1.2381237063534 0.136520476294394 no 2905 0.107835097491072 4309 2830968 YPR165W RHO1
SGTC_2206 7254556 146.969 µM -1.23945365548891 0.136234284962821 no 2906 0.1075887707711 4350 4398905
SGTC_2056 5235370 200 µM -1.24054688427529 0.135999341053147 no 2907 0.107386592074124 4233 5511916
SGTC_2436 5633522 8.09 µM -1.24094307360912 0.13591426520491 no 2908 0.107313389569859 4299 5724242
SGTC_3135 9127742 49.47 µM -1.2432202962087 0.135425971775606 no 2909 0.106893332766009 4412 3643468
SGTC_1913 st060213 96.1 µM -1.24481135976216 0.135085522269654 no 2910 0.10660054974046 4336 688959
SGTC_2696 st077691 74.316 µM -1.24485422233063 0.135076358832009 no 2911 0.1065926703067 4374 757133
SGTC_928 2764-0428 58.7 µM -1.24524406117918 0.134993036125827 no 2912 0.106521025459713 4346 662578
SGTC_1203 3992-3522 103 µM -1.24543313151406 0.13495263763272 no 2913 0.106486290507586 4432 5322312
SGTC_1794 st048918 76.9 µM -1.24707728844129 0.134601681664198 no 2914 0.106184579831948 4262 672303
SGTC_3107 9121808 49.47 µM -1.24755254278012 0.13450035235419 no 2915 0.106097483538 4272 662681
SGTC_2063 5246145 200 µM -1.24960877068926 0.134062546065451 no 2916 0.105721248816375 4369 711240
SGTC_3302 9125395 16.351 µM -1.25050370331857 0.133872305653633 no 2917 0.105557801677461 4268 17599668
SGTC_1470 k295-0292 231 µM -1.25050902659859 0.133871174612124 no 2918 0.105556830000584 4397 5045612
SGTC_1760 st045453 10.4495 µM -1.25165219662621 0.133628436507707 no 2919 0.105348313003751 4370 3323419 YIL048W NEO1
SGTC_2473 5854593 8.94 µM -1.25473380802725 0.132975602352023 no 2920 0.104787704244548 4231 2872951
SGTC_2981 9013952 38.96 µM -1.25602929210632 0.13270181286443 no 2921 0.104552675035682 4288 2996344
SGTC_1171 0368-0077 21.4 µM -1.25798537858784 0.13228914688551 no 2922 0.104198522078663 4286 3239779
SGTC_2650 prasterone 100 µM -1.25923568901534 0.132025838894348 no 2923 0.103972607172175 4324 16759247 A steroid and weak partial agonist of the androgen receptor.
SGTC_3289 9119912 71.43 µM -1.26039260541796 0.131782521273892 no 2924 0.103763883939712 4353 17014829
SGTC_1115 galangin 695.678 nM -1.26094108492308 0.131667275625456 no 2925 0.103665037163059 4413 5281616 Galangin is a flavonoid found in medicinal herbs. An inhibitor of cancer cell proliferation, galangin is used to study mechanisms of genotoxicity.
SGTC_1878 temozolomide 1 mM -1.26220774726965 0.131401392364644 no 2926 0.10343702085588 4270 5394 DNA alkylating agent.
SGTC_3257 9139206 32.98 µM -1.26354915779334 0.131120223228396 no 2927 0.103195946000766 4339 4910041
SGTC_3298 9116858 71.43 µM -1.26593334177831 0.130621507779744 no 2928 0.102768474083994 4400 2506942
SGTC_1778 st046819 58.9 µM -1.26666128195923 0.130469501429013 no 2929 0.102638214935666 4378 671715
SGTC_656 4090-1979 187 µM -1.26938585773618 0.129901649535719 no 2930 0.102151738830432 4367 22330961
SGTC_2050 5263056 171 µM -1.27501756301746 0.128733327885066 no 2931 0.101151512828531 4330 763468 YGL055W OLE1
SGTC_57 miconazole 162.5 nM -1.27758255697563 0.128203632420882 no 2932 0.100698327063051 4198 4189 Miconazole, an imidazole, is a topically used antifungal that acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2919 7978188 46.38 µM -1.27854927645708 0.128004389003867 no 2933 0.100527910875111 4360 2980291
SGTC_189 3970-0742 2.116 µM -1.27963167431584 0.127781559360324 no 2934 0.100337352348373 4330 2891807
SGTC_1087 pterostilbene 9.05 µM -1.28048722604363 0.127605620642367 no 2935 0.100186917220872 4351 5281727 Similar to reservatol, lowers cholesterol.
SGTC_1354 1498-1681 81 µM -1.28225240409744 0.127243155488581 no 2936 0.0998770592316392 4332 5754243
SGTC_611 3453-1652 23.7 µM -1.28441455542596 0.126800151874234 no 2937 0.0994984713715049 4374 1560575
SGTC_2877 9040724 71.43 µM -1.28608638621234 0.126458347123245 no 2938 0.099206457373193 4320 6463895
SGTC_529 4076-0302 30.3 µM -1.29265503258958 0.125121609482221 no 2939 0.0980651983890776 4318 5816522
SGTC_446 go6976 132 µM -1.2928115415901 0.125089880288141 no 2940 0.0980381238082375 4386 3501 A protein kinase C inhibitor.
SGTC_2723 salbutamol 83.58 µM -1.29340837045978 0.124968936272446 no 2941 0.0979349283111277 4360 9884233 β2-adrenoceptor agonist
SGTC_2289 7946404 165.07 µM -1.29499623369887 0.124647562556484 no 2942 0.0976607643693918 4347 1246120 YPR165W RHO1
SGTC_3291 9121177 71.43 µM -1.29534853498616 0.124576337322961 no 2943 0.09760001161281 4353 17015612
SGTC_751 0833-0568 350 µM -1.29560863504161 0.124523770798455 no 2944 0.0975551763264102 4383 6954252
SGTC_968 1309-0633 340 µM -1.29580110052331 0.124484883284533 no 2945 0.0975220094149092 4392 3761976
SGTC_2106 5357045 167.29 µM -1.29629748753937 0.124384627832064 no 2946 0.0974365069261104 4380 668842
SGTC_3058 9093861 49.47 µM -1.29785199624595 0.124071028522096 no 2947 0.0971690991023584 4382 17217477
SGTC_1090 efavirenz 20.7 µM -1.29847684084438 0.123945131305213 no 2948 0.0970617647205238 4387 64139 A non-nucleoside reverse transcriptase inhibitor.
SGTC_572 0960-0087 17.7 µM -1.30035313739558 0.123567621910111 no 2949 0.0967399818174141 4342 6796365
SGTC_2009 4012297 12.05 µM -1.3030020019873 0.12303604444255 no 2950 0.0962870390422833 4341 45595307
SGTC_3084 9116877 49.47 µM -1.30336870868344 0.12296257979938 no 2951 0.0962244570376431 4316 27241325
SGTC_277 nystatin 15.5 µM -1.30697129962577 0.122242485205232 no 2952 0.0956112295030405 4385 11468707 Nystatin is a polyene antifungal that binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
SGTC_2583 asiatic acid 100 µM -1.30798892388935 0.122039617299367 no 2953 0.0954385330559318 4391 5320556 A kinase inhibitor; arrests cells at G2/M.
SGTC_1562 morin hydrate 59.1 µM -1.30915083029686 0.121808275340404 no 2954 0.0952416320026214 4393 18542136 Morin hydrate is a flavonoid with antioxidant properties. Morin not only scavenges oxyradicals, but also moderately inhibits xanthine oxidase.
SGTC_3251 9135047 49.47 µM -1.31577318239712 0.120495610973268 no 2955 0.0941250914229408 4413 17682963
SGTC_251 melphalan 456.522 µM -1.32191250389284 0.119287618981831 no 2956 0.0930986441031615 4423 460612 A DNA alkylator.
SGTC_3287 9117173 37.0625 µM -1.32402917901869 0.118873123486731 no 2957 0.0927466770814623 4387 2789709
SGTC_3127 9126946 49.47 µM -1.3257429688422 0.118538268569002 no 2958 0.0924624247106932 4349 27243249
SGTC_1675 st018485 24.5 µM -1.3267257074504 0.118346553684915 no 2959 0.0922997169178695 4405 3323024
SGTC_2553 4-methylesculetin 85.09 µM -1.32793488540516 0.118110965409947 no 2960 0.0920998094324185 4408 5319502
SGTC_812 4251-0442 148 µM -1.32850119567204 0.118000743365213 no 2961 0.0920062944186835 4402 5723007
SGTC_1821 st053465 65.6 µM -1.32964254309668 0.117778821885404 no 2962 0.0918180369977995 4394 675086
SGTC_3178 9107506 49.47 µM -1.33124403870349 0.117467928259002 no 2963 0.0915543625737564 4386 8897194
SGTC_2689 tacrolimus 100 µM -1.33128745225745 0.117459508610527 no 2964 0.0915472226726915 4390 23581796 Tacrolimus, also known as FK-506, is a potent immunosuppressant, neuroprotective and neuroregenerative, and T cell proliferation blocker. FK-506 disrupts calcineurin-mediated signal transduction in T lymphocytes and interacts with its FK-506-binding protein-12 (FKBP12).
SGTC_1148 3909-7663 27.7 µM -1.3322343780567 0.117275967599408 no 2965 0.0913915915413281 4424 4084526
SGTC_2748 diazoxide 86.69 µM -1.33371276659773 0.116989820384117 no 2966 0.0911490045883207 4466 3019 A potassium channel activatior.
SGTC_2718 lomofungin 53.02 µM -1.33427623547003 0.116880889366654 no 2967 0.0910566714685352 4366 5351222 A RNA synthesis inhibitor.
SGTC_925 2064-1272 59.6 µM -1.3361659691355 0.116516086897996 no 2968 0.0907475157579764 4355 6815817
SGTC_732 3970-1727 52.7 µM -1.33767114708208 0.116226099080025 no 2969 0.0905018302407756 4472 1275699
SGTC_2820 7989630 71.43 µM -1.33767396309577 0.116225557026808 no 2970 0.0905013710548869 4419 2984098
SGTC_2327 6189656 200 µM -1.33960210421212 0.115854831046079 no 2971 0.0901873696806275 4462 5349088
SGTC_1395 3486-0190 4.35 µM -1.34592104320765 0.11464576867295 no 2972 0.0891639907859174 4370 6748079
SGTC_1146 3579-1023 7 µM -1.34783810974574 0.1142807398113 no 2973 0.0888552287880673 4425 X1146
SGTC_2752 diclazuril 33.15 µM -1.34936139329409 0.11399128186222 no 2974 0.0886104574614049 4326 456389 An antifungal agent for coccidioides. YHR062C RPP1
SGTC_2268 7933382 153.85 µM -1.3502498799432 0.113822690903928 no 2975 0.0884679216200072 4431 935025 YOR257W CDC31
SGTC_737 1950-0117 57.9 µM -1.35033255099621 0.113807013055397 no 2976 0.0884546677736626 4388 5393513
SGTC_1628 st004252 77.7 µM -1.3527547262565 0.113348351457882 no 2977 0.0880670003375656 4416 692968
SGTC_1469 k284-2957 126 µM -1.35384400483116 0.113142516703045 no 2978 0.0878930755727665 4400 23884841
SGTC_353 1988-1175 58.3 µM -1.35527481558762 0.112872550006283 no 2979 0.0876650078840413 4228 2788357
SGTC_2032 5185112 25.99 µM -1.35683498274143 0.112578700663198 no 2980 0.0874168246422595 4278 5718189
SGTC_1257 0669-0121 16 µM -1.35742170072464 0.11246833689059 no 2981 0.0873236284301913 4400 4307855
SGTC_2511 berberine 10.47 µM -1.35901034289234 0.112169895586725 no 2982 0.0870716556359148 4385 12456 Berberine is a quaternary ammonium salt and isoquinoline alkaloid.
SGTC_2836 9010338 19.48 µM -1.36327422102872 0.11137168574636 no 2983 0.0863980516753136 4377 2994051
SGTC_766 1391-0721 126 µM -1.36448848905862 0.111145116978637 no 2984 0.0862069372996997 4432 1020919 YIL115C NUP159
SGTC_927 2425-1185 123 µM -1.36573149681722 0.110913527753669 no 2985 0.0860116272666033 4353 730375
SGTC_2923 7992654 58.14 µM -1.36910087663765 0.110287505568209 no 2986 0.0854838721714029 4401 2985126
SGTC_1791 st048313 56.1 µM -1.37026281812808 0.110072208516763 no 2987 0.0853024376330858 4436 1204976
SGTC_158 k038-0087 26.446 µM -1.37242755419577 0.109671907364116 no 2988 0.0849651886252205 4330 X158
SGTC_2086 5274770 176.623 µM -1.37263392764945 0.109633799599859 no 2989 0.0849330895069857 4454 689278
SGTC_1417 3966-0327 90.4 µM -1.3729252918897 0.109580014101222 no 2990 0.0848877864863677 4491 651118
SGTC_3310 9130229 44.1445 µM -1.37476159991542 0.109241469751437 no 2991 0.0846026833457594 4433 7761258
SGTC_1976 st070609 63.5 µM -1.37503502401758 0.109191125243196 no 2992 0.0845602933297522 4366 682556
SGTC_2546 rhodinyl acetate 100 µM -1.37717599701039 0.108797492551114 no 2993 0.0842289204972512 4366 6708682
SGTC_2721 ifenprodil 61.44 µM -1.38359520817134 0.107623394636676 no 2994 0.0832412182012599 4419 3689 Ifenprodil is a selective antagonist of the NMDA glutamate receptor.
SGTC_1256 0570-0116 285 µM -1.38404080207793 0.107542234002683 no 2995 0.0831729807636621 4419 410638
SGTC_65 0798-0905 34.986 µM -1.38560629244853 0.107257444722814 no 2996 0.0829335778839986 4442 3602145
SGTC_113 0099-0221 2.5 µM -1.38605896386097 0.107175197544258 no 2997 0.0828644497400095 4391 89219
SGTC_2205 7238770 200 µM -1.38758671554871 0.106897951696633 no 2998 0.0826314644751272 4479 279867
SGTC_1033 k072-0102 21.3 µM -1.38762316920898 0.106891342663876 no 2999 0.082625911245901 4389 5965931
SGTC_1160 4092-0570 10.5 µM -1.38989030630628 0.106480890798711 no 3000 0.0822810948287395 4433 4994975
SGTC_1252 0493-0875 34.8 µM -1.39013937634894 0.106435867596829 no 3001 0.0822432791048383 4403 3960963
SGTC_763 3453-1109 128 µM -1.39647382846926 0.105295435529112 no 3002 0.0812859281953348 4465 1560353
SGTC_2221 6807166 181.081 µM -1.40098942004135 0.104487879472729 no 3003 0.0806086184585214 4408 674925
SGTC_2799 7812892 81.82 µM -1.40509663674882 0.103757261472922 no 3004 0.0799962720460945 4455 20205235
SGTC_470 aa-861 153 µM -1.40770492554717 0.103295210617404 no 3005 0.0796092313606359 4396 1967 aa-861 is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
SGTC_1179 1021-1431 9.29 µM -1.41104770219232 0.102705233904693 no 3006 0.0791152744932141 4462 2840958
SGTC_3347 9188721 44.724 µM -1.41391092481337 0.102201845549829 no 3007 0.0786940289249333 4457 44118411 YKL104C | YBL026W GFA1 | LSM2
SGTC_406 estrone 100 µM -1.41441758710663 0.102112955548678 no 3008 0.0786196646315136 4429 5870 A steroid.
SGTC_2605 digitonin 300 nM -1.41702641117952 0.101656147797516 no 3009 0.0782376028932023 4448 2735010 Digitonin is a glycoside obtained from Digitalis purpurea. As a detergent, it effectively water-solubilizes lipids and has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
SGTC_1233 0325-0408 14.2 µM -1.4178629568333 0.10150998333724 no 3010 0.078115389593519 4483 12874
SGTC_115 0527-0192 112.043 µM -1.41872205691781 0.101360037449255 no 3011 0.0779900320367187 4431 4233931
SGTC_394 menadione 8.33 µM -1.41970554444509 0.101188579354323 no 3012 0.0778467116547736 4474 4055 Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. As a free radical generator, menadione is often used as a research tool to induce oxidative stress.
SGTC_2190 6049624 200 µM -1.42024601360577 0.101094445711579 no 3013 0.0777680360247307 4337 2265554
SGTC_2917 7979103 53.79 µM -1.42328652722697 0.100566068055491 no 3014 0.0773265554896731 4444 2980565
SGTC_1837 st055472 66.5 µM -1.42392435479893 0.10045548306828 no 3015 0.0772341853981176 4504 676091
SGTC_111 0083-0039 52.457 µM -1.42654760099199 0.100001603892533 no 3016 0.0768551684959038 4410 759313
SGTC_1309 pyrazolanthrone 13.4 µM -1.42727191787778 0.0998765454023001 no 3017 0.0767507658788356 4436 8515 1,9-Pyrazoloanthrone is derivative of anthrone used in biochemical studies to inhihibit mitogen-activated protein kinase c. YJR013W GPI14
SGTC_1499 4480-0877 67.3 µM -1.42832631212145 0.0996947009260578 no 3018 0.0765989789030286 4437 2861909
SGTC_270 tamoxifen 5.46 µM -1.42922318682725 0.0995402133024109 no 3019 0.0764700476899435 4475 5376 Used for treating and preventing breast cancer, tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. YIL048W NEO1
SGTC_2996 9066192 71.4286 µM -1.43028917738433 0.0993568229322765 no 3020 0.0763170198458281 4439 6472854
SGTC_682 0kpi-0099 17 µM -1.43037008518846 0.0993429138462854 no 3021 0.0763054146800375 4463 1714895 YML126C ERG13
SGTC_1915 st067105 30.6 µM -1.43854717947992 0.0979444992908059 no 3022 0.0751394305281556 4403 69751 YOR207C | YOR116C RET1 | RPO31
SGTC_2353 9059630 146.67 µM -1.43910324442718 0.0978499297851532 no 3023 0.0750606364704373 4503 4779114
SGTC_3093 9117344 49.47 µM -1.4440092075314 0.0970184753873197 no 3024 0.0743681926729736 4485 24824913
SGTC_475 α-linolenic acid 10 µM -1.44506912074725 0.0968395263240837 no 3025 0.0742192357537805 4460 5280934 Alpha-linolenic acid (ALA) is a polyunsaturated n−3 (omega-3) fatty acid. ALA has been noted to be a reactive oxygen species scavenger that temporarily improves cell proliferation.
SGTC_84 0443-0269 128.823 µM -1.45013992129209 0.0959867570036714 no 3026 0.0735097522836455 4404 6150058
SGTC_2278 7948257 134.34 µM -1.4504762569558 0.0959303904939437 no 3027 0.0734628777584196 4466 1247028
SGTC_3194 9111903 49.47 µM -1.45061089438911 0.0959078334243007 no 3028 0.0734441199780092 4467 17087251
SGTC_893 0958-0369 48.9 µM -1.45615617644743 0.0949821664221987 no 3029 0.0726747255047672 4341 6819948
SGTC_3076 9116187 49.47 µM -1.45670454049487 0.0948909875256661 no 3030 0.0725989779492984 4469 27241210
SGTC_424 splitomicin 100 mM -1.46322678025687 0.0938114470202825 no 3031 0.0717026675996974 4472 5269 Sir2p (silent information regulator) and HDAC inhibitor.
SGTC_5 0352-0601 109.883 µM -1.46452123612502 0.0935982752200578 no 3032 0.0715257925238062 4385 762456
SGTC_1369 1866-0067 208 µM -1.46453910173245 0.0935953356052306 no 3033 0.0715233537029892 4494 3531355
SGTC_234 nsc-17383 10.7 µM -1.46520355704196 0.0934860542529617 no 3034 0.0714326947131063 4478 408974
SGTC_2396 5342950 42.78 µM -1.46567034909188 0.0934093384745131 no 3035 0.0713690578688538 4467 1886677
SGTC_1270 0831-1170 17.3 µM -1.46599260406589 0.093356404041517 no 3036 0.0713251508763553 4489 6764716
SGTC_2180 6301957 200 µM -1.46602536340304 0.0933510241494639 no 3037 0.0713206886031564 4490 845462
SGTC_163 TUB2.036 7.546 µM -1.46686908411266 0.0932125432772312 no 3038 0.0712058360340703 4413 15992207 YJR013W GPI14
SGTC_2948 9070189 9.45 µM -1.47061556834559 0.092599461690195 no 3039 0.0706975556286536 4420 6473636 YDL196W YDL196W
SGTC_3263 9137018 49.47 µM -1.47144395785594 0.0924643061001254 no 3040 0.0705855464651422 4433 43844957
SGTC_781 4335-2806 94.4 µM -1.47319786458727 0.092178629845375 no 3041 0.0703488453612146 4527 845254
SGTC_220 paclitaxel 373.376 µM -1.47412895353888 0.0920272398626835 no 3042 0.0702234371126104 4458 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_1152 3909-8331 15.9 µM -1.47777203635314 0.0914366637530522 no 3043 0.0697344027706878 4465 16001939
SGTC_965 1291-5240 308 µM -1.47778373244083 0.0914347722478549 no 3044 0.0697328369624608 4469 2834598
SGTC_1590 st077108 57.8 µM -1.4779055492174 0.0914150736180918 no 3045 0.0697165304076799 4494 5489485
SGTC_161 4065-0411 162.148 µM -1.47878243226578 0.0912733682750219 no 3046 0.0695992362841536 4467 1906281 YLR208W SEC13
SGTC_1291 0993-0025 5.79 µM -1.47941727200546 0.0911708790997409 no 3047 0.0695144133556947 4473 4353356
SGTC_973 1325-0077 65.9 µM -1.48242520246461 0.0906864356589103 no 3048 0.069113596089845 4491 2835149
SGTC_376 3970-0862 59.1 µM -1.48643342901387 0.090043861758769 no 3049 0.0685822565555553 4500 3135186
SGTC_2102 5377816 72.7585 µM -1.49045604972306 0.0894023877188994 no 3050 0.0680521821936761 4523 1379702
SGTC_570 0987-0065 62.6 µM -1.49449969213086 0.0887609936380362 no 3051 0.0675225311633531 4345 3104428
SGTC_842 0271-0008 11.1 µM -1.49465373480132 0.0887366276447584 no 3052 0.0675024172589608 4512 1221709
SGTC_1922 5578187 25 µM -1.49885902941676 0.088073369859793 no 3053 0.0669551035314452 4490 1350412
SGTC_870 0573-2213 57.6 µM -1.49930056351813 0.0880039462174069 no 3054 0.0668978381306541 4481 3916321
SGTC_1689 st020265 53.493 µM -1.50000617433257 0.0878930857764733 no 3055 0.0668064015878513 4485 5758320 YPR016C TIF6
SGTC_814 3342-0569 96 µM -1.50386908677148 0.0872880183474938 no 3056 0.0663075390311332 4530 4346283
SGTC_1025 k007-0731 70 µM -1.50529479594863 0.0870654897813196 no 3057 0.0661241512741491 4474 6256118
SGTC_700 3453-2283 142 µM -1.50831627349843 0.0865952902681054 no 3058 0.0657368000892928 4525 565664
SGTC_1113 artemisinin 1.17947 µM -1.50971829621635 0.0863777546185075 no 3059 0.0655576603335051 4531 2240 An anti-malaria and mitochondrial poison.
SGTC_2670 beta-carotene 100 µM -1.51188014024101 0.0860431274895382 no 3060 0.0652821785708252 4475 5280489 A carotenoid that is a precursor of VITAMIN A. It is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). (From Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Engewood, CO, 1995.)
SGTC_3271 9137798 49.47 µM -1.51683026895373 0.0852805624186246 no 3061 0.0646547713516668 4506 6498326
SGTC_173 1273-0061 2.693 µM -1.51741345598287 0.0851910571684166 no 3062 0.0645811643573968 4457 2847414 YPL266W DIM1
SGTC_3143 9086658 49.47 µM -1.5180193092551 0.0850981477577288 no 3063 0.0645047654947377 4482 25236626
SGTC_480 am 92016 50 µM -1.51866174730262 0.0849997109383572 no 3064 0.0644238299659082 4522 2129 K+ channel blocker.
SGTC_1573 oleylamine 1.06 µM -1.51958366768756 0.0848585999187112 no 3065 0.0643078226238931 4497 5356789 An amine of the fatty acid oleic acid.
SGTC_2318 6029776 164 µM -1.52002607468434 0.0847909465958371 no 3066 0.0642522112181315 4524 818325
SGTC_1753 st043925 64 µM -1.52054263350258 0.0847120050903337 no 3067 0.0641873260941293 4529 670181
SGTC_1824 st053723 68.6 µM -1.52165121410641 0.0845427757718595 no 3068 0.064048248869879 4529 675225
SGTC_1927 st060202 13.8 µM -1.52199626854338 0.084490153601682 no 3069 0.0640050078354102 4441 688887
SGTC_997 3996-0078 137 µM -1.5225894858624 0.0843997430499066 no 3070 0.0639307209453684 4557 735687
SGTC_1973 st070275 50.2 µM -1.52684477124796 0.0837533340800711 no 3071 0.063399807813369 4480 17118334
SGTC_3342 9147791 14.508 µM -1.52873426647293 0.0834675011147251 no 3072 0.0631651669148679 4471 1838168
SGTC_104 0074-0074 590.992 µM -1.52882271620891 0.0834541388857243 no 3073 0.0631541996593196 4367 3943124
SGTC_670 4204-0025 119 µM -1.53423895703678 0.0826389596686821 no 3074 0.0624854384635744 4523 719039
SGTC_702 1488-0190 94 µM -1.53619962007788 0.0823453493093645 no 3075 0.0622447145876796 4555 949357
SGTC_1586 deoxycorticosterone acetate 53.7 µM -1.5363982621745 0.0823156464267182 no 3076 0.0622203663627967 4512 5952 Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.
SGTC_2740 felodipine 17.08 µM -1.53664971497522 0.0822780583501061 no 3077 0.0621895556087158 4568 3333 L-type calcium channel blocker
SGTC_2741 miltefosine 3.04 µM -1.53774590535969 0.0821143468301943 no 3078 0.0620553773584133 4565 3599 Inhibitor of protein kinase C and of phosphatidylcholine synthesis.
SGTC_271 rotenone 740 µM -1.53986183023701 0.0817990363230665 no 3079 0.0617970182938878 4541 5102 Inhibits electron transfer from iron-sulfur centers in mitochondria.
SGTC_1683 st010134 710 nM -1.54034192432624 0.0817276209383263 no 3080 0.0617385147876763 4484 3818134
SGTC_2525 harmine 47.85 µM -1.54115741313703 0.0816064223564486 no 3081 0.0616392397223242 4522 5280953 A monoamine oxidase inhibitor
SGTC_1261 0712-0010 12.7 µM -1.54247266540499 0.0814112341507656 no 3082 0.0614793877005513 4492 2840123
SGTC_207 4185-0010 4.486 µM -1.54393097747068 0.0811952272372388 no 3083 0.0613025273245984 4582 3761753
SGTC_2524 avocatin b 10.57 µM -1.54711329357314 0.0807253606601702 no 3084 0.0609179644641353 4535 6710748
SGTC_1490 4089-0339 670 nM -1.55014631217831 0.0802794515652897 no 3085 0.0605532012146864 4505 742542
SGTC_851 0394-0702 453 µM -1.55154628832129 0.0800742584936984 no 3086 0.060385411762474 4529 762646
SGTC_658 3253-0951 102 µM -1.55290280910432 0.0798758130976613 no 3087 0.0602231778004973 4540 1184878
SGTC_807 1315-0151 48 µM -1.55362330625791 0.0797705629317201 no 3088 0.0601371483316142 4522 4011080
SGTC_1452 4194-0072 190 µM -1.55574076618042 0.0794618517227693 no 3089 0.0598848742519482 4573 1343545
SGTC_936 3005-4620 401 µM -1.55637735478403 0.0793692184470665 no 3090 0.0598091933983547 4538 777207
SGTC_2204 7233102 200 µM -1.55819939343438 0.0791045360379108 no 3091 0.0595929943692215 4514 2172480
SGTC_2488 5268135 45.7 µM -1.56035538697306 0.0787922049960805 no 3092 0.0593379606702281 4547 1270356 YLR208W SEC13
SGTC_1133 3473-0247 50 µM -1.56055917094831 0.0787627319433783 no 3093 0.0593138992798345 4487 711311
SGTC_102 gallobenzophenone 83.616 µM -1.56060497677622 0.0787561082467899 no 3094 0.0593084919003485 4505 70837
SGTC_1921 5740136 50 µM -1.56408645176028 0.0782539079618067 no 3095 0.0588986336135397 4466 1774243
SGTC_646 4092-0839 27.3 µM -1.56603037933758 0.0779745564286502 no 3096 0.0586707526272252 4545 877796
SGTC_3150 9097574 49.47 µM -1.56726995388368 0.0777968192280969 no 3097 0.0585258026527349 4558 17217476
SGTC_1843 st055809 45.5 µM -1.57126113489316 0.0772266299271004 no 3098 0.0580610024128707 4565 16413835
SGTC_1860 st056228 74.6 µM -1.58538151324599 0.0752348305563471 no 3099 0.0564398394330877 4526 688679
SGTC_1564 D-Arginine 115 µM -1.58636683295152 0.075097318414257 no 3100 0.0563280598142087 4533 71070 D-isomer of arginine; arginine decarboxylase inhibitor.
SGTC_511 blebbistatin 171 µM -1.58658415825745 0.0750670141061554 no 3101 0.0563034288451153 4581 3476986 A myosin inhibitor.
SGTC_1979 st071809 45.3 µM -1.58717195898952 0.0749850966312681 no 3102 0.056236851889786 4575 4976333
SGTC_2495 cafestol 54.53 µM -1.59045428611295 0.0745289156785438 no 3103 0.0558662210521056 4528 16667697 An anti-infammatory.
SGTC_3068 9116768 49.47 µM -1.59194823126072 0.0743219886022132 no 3104 0.0556981685343167 4507 41904888
SGTC_2827 7993847 71.43 µM -1.59221444601147 0.0742851611641882 no 3105 0.0556682642040882 4573 2985692
SGTC_1570 verbenone 133 µM -1.59410185719917 0.0740244612621405 no 3106 0.0554566115145787 4551 29025 A natural terpanoid with antifungal properties.
SGTC_141 0443-0274 32.331 µM -1.59461841135096 0.0739532338556159 no 3107 0.0553987964432185 4477 1627241
SGTC_1561 5-methoxyflavone 52.9 µM -1.59613479813186 0.0737444425074208 no 3108 0.0552293504883671 4515 94525
SGTC_2742 clothiapine 36.27 µM -1.59755231624873 0.0735496721440424 no 3109 0.0550713228822739 4587 16351 An atypical antipsychotic. YIL048W NEO1
SGTC_2217 6934799 96.0675 µM -1.60381088260998 0.0726944296361417 no 3110 0.0543778725300091 4521 675606
SGTC_1453 4237-0541 195 µM -1.60721284728755 0.0722327519553679 no 3111 0.0540038423671961 4547 739892
SGTC_745 0469-0705 296 µM -1.60891439333728 0.0720026812827588 no 3112 0.0538175308842817 4571 3486736
SGTC_2647 atorvastatin 60.16 µM -1.61438329963975 0.0712670196738102 no 3113 0.0532221559278036 4532 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YPR034W ARP7
SGTC_193 1273-0060 1.558 µM -1.61874063934448 0.0706850240575821 no 3114 0.0527515394768399 4412 2847393 YHR072W ERG7
SGTC_810 3825-7150 143 µM -1.62413093145806 0.0699701223989313 no 3115 0.0521739338705021 4569 22330411 YGL099W LSG1
SGTC_3208 9114115 49.47 µM -1.62611908826566 0.069707846846881 no 3116 0.0519621620557692 4516 650895
SGTC_2246 7293507 91.5585 µM -1.62642260608362 0.0696678737689052 no 3117 0.0519298925285244 4587 887656
SGTC_2915 7971052 15.16 µM -1.63297114394384 0.0688097271236201 no 3118 0.0512375328760405 4526 5741558
SGTC_2407 paclitaxel 400 µM -1.63527925670542 0.0685092129534339 no 3119 0.0509952599859906 4579 4666 Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase
SGTC_3212 9128307 49.47 µM -1.64288612965504 0.0675259687651649 no 3120 0.0502032476648176 4465 27243542
SGTC_1988 st071872 53.4 µM -1.64345887021264 0.0674523815593189 no 3121 0.0501440142161928 4603 16414116
SGTC_338 4055-0136 114 µM -1.64627511115317 0.0670914448390569 no 3122 0.0498535656241857 4547 2900563
SGTC_1811 st050069 61.5 µM -1.64667850814138 0.0670398669606486 no 3123 0.0498120720035613 4573 3877702
SGTC_1127 asiatic acid 681.4 nM -1.66799610510345 0.0643576115602935 no 3124 0.0476582499854516 4526 470603 A kinase inhibitor which arrests cells at G2/M.
SGTC_844 0330-0132 15.3 µM -1.67355758377304 0.0636717482449392 no 3125 0.047108790279118 4619 2828079
SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 54.59 µM -1.67507526666234 0.0634855728184604 no 3126 0.046959732511969 4541 5098884 YER133W | YBR257W | YHR062C GLC7 | POP4 | RPP1
SGTC_1394 3474-0001 65.7 µM -1.67790561073801 0.0631395042584004 no 3127 0.0466827635247606 4575 5017666 YIL048W NEO1
SGTC_734 2023-0417 80 µM -1.6821595174297 0.0626221409593478 no 3128 0.0462689558988906 4581 3935732
SGTC_2483 5729050 27.16 µM -1.68645264727876 0.0621033635422461 no 3129 0.0458543241797932 4563 2865180
SGTC_489 paxilline 115 µM -1.6900617416382 0.0616698437107257 no 3130 0.0455080716223694 4549 105008 A toxic potassium channel blocker.
SGTC_3202 9113761 49.47 µM -1.69643389150583 0.0609102020363666 no 3131 0.0449018699448344 4517 4798415
SGTC_1612 st002233 45.4 µM -1.69874479825865 0.0606365271377774 no 3132 0.0446836393335085 4604 1035021
SGTC_1088 bifonazole 369 nM -1.69997150882625 0.0604916421986865 no 3133 0.0445681423920406 4593 2378 Bifonazole, an imidazole, has a dual mechanism; topical antifungal that inhibits lanosterol 14α-demethylase as will as Hmg-CoA reductase.
SGTC_3086 9117350 49.47 µM -1.70507631161953 0.059891628664597 no 3134 0.0440900964716866 4578 2679265
SGTC_1998 st075797 76.8 µM -1.70526664445661 0.0598693476001423 no 3135 0.0440723527650283 4579 24208315
SGTC_3108 9121785 49.47 µM -1.70829899119951 0.0595152449486249 no 3136 0.0437904392026717 4473 17140271
SGTC_1416 3966-0321 25.3 µM -1.70899155799626 0.0594346011088568 no 3137 0.0437262566211021 4645 582530 YLR208W SEC13
SGTC_2518 prenyletin 46.28 µM -1.71036691256699 0.0592747061033718 no 3138 0.0435990227470286 4622 3873459 A coumarin with calcium channel inhibitory activity.
SGTC_294 k038-0071 157 µM -1.71037071110058 0.0592742649636603 no 3139 0.0435986717593549 4616 24152826
SGTC_2115 tiliquinol 12.7705 µM -1.71704096098956 0.0585035840946091 no 3140 0.0429858440629685 4573 71208 A bioactive hydroxyquinoline.
SGTC_1365 1672-3266 55.4 µM -1.71760441020435 0.0584388452260559 no 3141 0.0429343976832808 4616 6415873
SGTC_2860 9025725 38.96 µM -1.72376906226976 0.0577342120017249 no 3142 0.0423747708869921 4627 40546248
SGTC_1815 st051655 58.2 µM -1.7237729290055 0.0577337721312383 no 3143 0.0423744217256212 4566 5984156
SGTC_3132 9126706 49.47 µM -1.72421211212311 0.0576838288685562 no 3144 0.0423347791838942 4603 850858
SGTC_1655 st012546 55.1 µM -1.72438368408421 0.0576643271868716 no 3145 0.0423193005188758 4593 720985 YLR208W SEC13
SGTC_1103 duloxetine 36.1 µM -1.72457593731306 0.0576424809346296 no 3146 0.0423019614969443 4640 60835 A selective serotonin reuptake inhibitor.
SGTC_309 k408-0051 1.48 µM -1.72718699641102 0.057346423312834 no 3147 0.0420670427227407 4519 3640463
SGTC_3155 9099265 49.47 µM -1.72729725922319 0.0573339474291799 no 3148 0.042057145585958 4580 25236499
SGTC_53 0973-0023 39.979 µM -1.72959636197567 0.0570742975425171 no 3149 0.0418512082487527 4529 674768
SGTC_1779 st039427 55 µM -1.73086578498602 0.0569313320224832 no 3150 0.0417378526725272 4591 1124498
SGTC_1056 3448-1962 115 µM -1.73576740976164 0.0563819440863279 no 3151 0.0413024844001995 4564 715507
SGTC_2043 5101342 149 µM -1.74024393075446 0.0558838618080886 no 3152 0.040908097361567 4622 678451
SGTC_1363 1636-0063 10.4 µM -1.74039019828263 0.055867646034637 no 3153 0.0408952627306774 4611 6072185
SGTC_3327 9140648 26.9345 µM -1.74158481901712 0.0557353447798372 no 3154 0.0407905598247882 4611 8029710
SGTC_2342 7990637 118.86 µM -1.74343127039551 0.0555313414509439 no 3155 0.0406291550215365 4585 2033102 YER133W GLC7
SGTC_2894 9048625 32.47 µM -1.74444384805756 0.055419718342834 no 3156 0.0405408623642196 4606 4092861
SGTC_2856 9022925 19.48 µM -1.74561780227383 0.0552905274769978 no 3157 0.0404386933651947 4604 4944862
SGTC_1855 st056195 39.6 µM -1.74689049498494 0.0551507394920549 no 3158 0.0403281674512075 4543 4028379
SGTC_245 methotrexate 289.6 µM -1.75004356189312 0.0548056205417781 no 3159 0.0400553986037307 4559 126941 Methotrexate is an antineoplastic antimetabolite with immunosuppresent properties. Potent inhibitor of dihydrofolate reductase (DHFR), a key enzyme in folic acid biosynthesis.Methotrexate inhibits folate-dependent processes including DNA, RNA and methionine biosyntheis. YOR074C | YOR236W | YFR051C CDC21 | DFR1 | RET2
SGTC_2369 9071472 200 µM -1.75030652623714 0.0547769150744993 no 3160 0.0400327176942368 4613 17296037
SGTC_296 1222-0039 74.9 µM -1.7512722018317 0.054671602849886 no 3161 0.0399495168243779 4626 5984176
SGTC_327 1273-0057 3.96 µM -1.75558678256646 0.0542030282584064 no 3162 0.0395794953591689 4531 3108138
SGTC_1022 4477-0945 21.3 µM -1.7567125794755 0.0540812880792973 no 3163 0.0394834061374035 4562 4648966
SGTC_2641 levomentholum 100 µM -1.75975139703179 0.0537537601211389 no 3164 0.0392249835537272 4623 16666
SGTC_98 0074-0023 107.663 µM -1.76120975100691 0.0535971355547699 no 3165 0.0391014541281506 4604 3563821
SGTC_1383 3049-0032 20.7 µM -1.77033693120592 0.0526250891876023 no 3166 0.0383355146563767 4649 712864
SGTC_1854 st056233 32.9 µM -1.77121302601317 0.0525325256076321 no 3167 0.0382626419744558 4549 5393174
SGTC_2866 9034245 58.44 µM -1.77311322053945 0.0523322051455779 no 3168 0.0381049738630146 4628 6462273
SGTC_201 4262-0159 12.803 µM -1.7741892757969 0.0522190355644362 no 3169 0.038015923749081 4664 1341029
SGTC_512 prima-1 270 µM -1.77605630761209 0.0520231396141896 no 3170 0.0378618183927364 4620 322968 A re-activator of the apoptotic function of mutant p53.
SGTC_1888 azatryptophan 97.5 µM -1.77679224521354 0.0519460829026239 no 3171 0.0378012141292586 4630 5354789 An unusual alpha-amino acid with strong fluorescent activity that is used as a vehicle for probing the structure and dynamics of protein and peptides
SGTC_2898 9056270 58.44 µM -1.77980294453437 0.0516317901159609 no 3172 0.037554107787167 4639 19154699
SGTC_2461 5755302 26.15 µM -1.78153188072998 0.0514519876075968 no 3173 0.0374128007484433 4610 2788904
SGTC_415 dibenzyl ketone 100 µM -1.78351686899475 0.0512461711396499 no 3174 0.0372511022416808 4601 7593
SGTC_1105 epirubicin 18.1 µM -1.78983123436622 0.0505958099123509 no 3175 0.0367405231479055 4647 65348 Epirubicin forms complexes with DNA by intercalation between base pairs, thereby preventing DNA replication. Additionally,epirubicin inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the topoisomerase II reaction.
SGTC_2886 9058944 51.95 µM -1.79062930232508 0.0505140813071687 no 3176 0.0366764007917072 4597 4949929
SGTC_3223 9129970 49.47 µM -1.79207004337828 0.0503668041360373 no 3177 0.036560873393805 4627 17248386
SGTC_569 4130-2812 160 µM -1.79339417956655 0.0502317486378923 no 3178 0.0364549588043752 4531 743552
SGTC_293 4049-0273 38.5 µM -1.7939812927221 0.0501719583732453 no 3179 0.0364080773943688 4521 1380311
SGTC_1433 4060-0023 7.6 µM -1.7963941065967 0.0499268383405956 no 3180 0.0362159302422697 4651 3840627
SGTC_429 1112-0049 25.5 µM -1.80417127448607 0.049143243792933 no 3181 0.0356022305192888 4591 2836170
SGTC_1956 st077085 54 µM -1.80545889197995 0.0490144617845974 no 3182 0.0355014513413572 4637 24208685
SGTC_3072 9116419 49.47 µM -1.80755848672359 0.0488050476478972 no 3183 0.0353376220980481 4622 17170162
SGTC_1063 disulfiram 1.84 µM -1.8101865218359 0.0485439350582431 no 3184 0.0351334335151869 4656 3117 Disulfiram blocks the oxidation of alcohol through its irreversible inactivation of aldehyde dehydrogenase.
SGTC_885 0865-0106 16.8 µM -1.81019456687159 0.0485431374493001 no 3185 0.03513280993519 4598 2793380
SGTC_3004 9076122 71.4286 µM -1.81519438054333 0.0480494642984824 no 3186 0.0347470214917289 4622 44782551
SGTC_980 1473-0395 201 µM -1.81604982428734 0.0479654031706571 no 3187 0.0346813647648961 4569 768876
SGTC_2469 5655019 90.81 µM -1.81753938746083 0.0478193105717919 no 3188 0.0345672815036827 4675 2788239
SGTC_3151 9099821 49.47 µM -1.82139624644932 0.0474426946686982 no 3189 0.034273322672362 4575 17174189
SGTC_1720 st037298 9.481 µM -1.82230728273764 0.0473540813669608 no 3190 0.0342041868955531 4613 597396
SGTC_2090 5301565 104.445 µM -1.82773604138711 0.0468287916454653 no 3191 0.0337945881248709 4648 2056344
SGTC_348 k064-0012 10.7 µM -1.82887507322001 0.0467191737094422 no 3192 0.0337091626036768 4613 5066323
SGTC_2708 st078559 56 µM -1.83197318502851 0.0464220594368442 no 3193 0.0334777078811319 4603 17250902
SGTC_2891 9063876 19.48 µM -1.83606009463715 0.046032440048672 no 3194 0.0331743846638454 4662 6472478
SGTC_2044 5102272 200 µM -1.83932978024466 0.0457226246919073 no 3195 0.0329333476999427 4643 592666
SGTC_1409 3909-8004 61.9 µM -1.84087204327759 0.0455770721703478 no 3196 0.0328201560794428 4670 2119279
SGTC_2764 methyldopa 94.69 µM -1.84256000061466 0.0454181968477077 no 3197 0.032696639277047 4599 38853 An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 63.64 µM -1.85108421958383 0.0446226653314089 no 3198 0.0320787189714519 4613 6728940
SGTC_3190 9110366 49.47 µM -1.8527556578132 0.0444680005679511 no 3199 0.0319586942456498 4645 17123768
SGTC_228 caffeine 993.056 µM -1.8527990621649 0.0444639899533096 no 3200 0.0319555823589444 4637 2519 Caffeine is a phosphodiesterase inhibitor.
SGTC_1870 st057514 26.5 µM -1.85363689124637 0.0443866306248041 no 3201 0.0318955629961727 4639 5393161
SGTC_2253 7938677 135.83 µM -1.85566512885202 0.0441998062600228 no 3202 0.0317506520744294 4661 2301972
SGTC_1155 4088-0394 48.2 µM -1.85899261380153 0.0438946795261835 no 3203 0.0315140926704544 4651 2326248
SGTC_2014 4013930 200 µM -1.85914598931857 0.0438806562220844 no 3204 0.0315032240322913 4613 64556
SGTC_2612 dictamnine 15.46 µM -1.86348298102329 0.0434856135537627 no 3205 0.0311971723992677 4554 68085 A quinoline derivative and established mutagen. YOR116C RPO31
SGTC_1653 st012112 65 µM -1.86431550834081 0.0434101107347267 no 3206 0.0311387051137298 4624 720429
SGTC_3203 9113543 49.47 µM -1.87197536024875 0.0427203859109697 no 3207 0.0306050062247603 4640 17018012
SGTC_117 lucigenin 22.078 µM -1.87307215691181 0.0426223548464715 no 3208 0.0305292107898778 4599 65100 An acridine derivative; a dye stuff and potential carcinogen.
SGTC_2626 ethyl orsellinate 100 µM -1.87750310500478 0.0422281693411692 no 3209 0.0302245860881521 4582 75653 A natural product.
SGTC_852 0418-0143 439 µM -1.877889389571 0.0421939449856999 no 3210 0.0301981490972492 4640 5369229
SGTC_3246 9135460 32.98 µM -1.88072335022502 0.0419435452723576 no 3211 0.0300047808022615 4655 41446951
SGTC_279 1273-0055 2.93 µM -1.88390855359259 0.041663548247308 no 3212 0.0297886730172127 4696 2847562
SGTC_2539 epi(13)torulosol 80 µM -1.88971733607966 0.0411568234159702 no 3213 0.0293978871347597 4615 6708597
SGTC_2808 7946468 45.46 µM -1.89368130398061 0.0408139067619812 no 3214 0.0291336621925825 4632 2970879
SGTC_1040 k898-0338 155 µM -1.89406526852774 0.0407808141013627 no 3215 0.0291081735314037 4632 20969351
SGTC_3142 9086498 49.47 µM -1.89567696697417 0.0406421444496126 no 3216 0.0290013864126502 4534 25236367
SGTC_147 4466-0538 29.23 µM -1.89575945356383 0.0406350576557639 no 3217 0.0289959298260376 4649 6742687 YHR072W ERG7
SGTC_1930 st074634 34.3 µM -1.89967789082518 0.0402995608938489 no 3218 0.0287377017404361 4583 684253 YOR116C RPO31
SGTC_1942 st076330 65.2 µM -1.90202750508311 0.0400994680744801 no 3219 0.0285837794255479 4668 24208414
SGTC_1841 st054148 70 µM -1.90714819406248 0.0396661870356534 no 3220 0.0282506999341712 4675 675442
SGTC_3 0833-0587 95.581 µM -1.91012989798881 0.03941565244605 no 3221 0.0280582451679828 4563 5382644
SGTC_1552 6-methylflavone 10.6 µM -1.9105066899544 0.0393840847118857 no 3222 0.0280340029244948 4628 689013
SGTC_3162 9099653 49.47 µM -1.91380951855914 0.0391082523690652 no 3223 0.0278222494166002 4649 25237511
SGTC_284 0988-0104 32.6 µM -1.92101060930477 0.0385123115697567 no 3224 0.0273651849896241 4641 4666532
SGTC_1322 1348-1070 12 µM -1.92605948292712 0.0380989117318565 no 3225 0.0270484734943211 4666 6758089
SGTC_1846 st056244 14.8 µM -1.93405233519087 0.0374518666978035 no 3226 0.0265533467549361 4677 5393182
SGTC_949 1165-0505 146 µM -1.94260741981467 0.0367692800156684 no 3227 0.0260318048656846 4662 6244267
SGTC_2125 5246583 200 µM -1.94361856884663 0.0366892798271164 no 3228 0.0259707324593547 4658 835267
SGTC_1059 3448-6867 171 µM -1.94632074238608 0.0364761874039609 no 3229 0.025808111746296 4643 3934407
SGTC_334 1502-1024 68.5 µM -1.95615284557944 0.035709362223133 no 3230 0.0252235757240575 4668 3296216
SGTC_2424 5537928 59.2 µM -1.96451283542197 0.0350677885623531 no 3231 0.0247353246284249 4670 5382802
SGTC_2064 5220758 200 µM -1.96473875419724 0.0350505829282989 no 3232 0.0247222410256549 4678 788518
SGTC_2664 lyso-paf C-16 73.48 µM -1.96731651997711 0.0348547542098073 no 3233 0.0245733658435093 4672 6710742 Lyso-PAF C-16 is a metabolite of the platelet-activating factor (PAF); natural occuring lipid involved in cellular signaling.
SGTC_289 k017-0060 526 µM -1.9688276224265 0.0347403763895205 no 3234 0.0244864445824295 4679 5512909
SGTC_1216 1165-0504 9.65 µM -1.9740883784245 0.034344583079953 no 3235 0.0241858472830861 4703 6304004
SGTC_819 1013-0258 27.7 µM -1.98607563926975 0.0334565522721958 no 3236 0.0235124628823582 4684 5753198
SGTC_1652 st011932 78 µM -1.99104248314709 0.0330941835433494 no 3237 0.0232381084508173 4647 1551076
SGTC_2876 9059903 25.97 µM -1.99326551757858 0.0329330471921127 no 3238 0.0231161900835402 4676 6916095
SGTC_1556 plumbagin 1.48 µM -1.99416908998926 0.0328677369601465 no 3239 0.0230667894387891 4622 10205 Like menadione, plumbagin is a naphthoquinone, and undergoes one electron reduction to semiquinone. Under aerobic conditions the semiquinone radical participates in redox cylcing to generate reactive oxygen species (ROS) such as superoxide and hydrogen peroxide.
SGTC_2048 5246248 200 µM -1.99850605543362 0.0325557453579618 no 3240 0.0228309120501067 4699 677046
SGTC_601 0986-0029 62.9 µM -2.00511432256201 0.0320850613084634 no 3241 0.0224754133255115 4654 24747981
SGTC_602 3130-1533 38.1 µM -2.01207200166396 0.0315955762208793 no 3242 0.0221061737914175 4700 720941
SGTC_2375 9072683 200 µM -2.01344691623782 0.0314995825476311 no 3243 0.0220338170759901 4715 16798029
SGTC_695 3505-6186 243 µM -2.02290953882673 0.0308454418092754 no 3244 0.0215412374593334 4667 1819379
SGTC_133 0724-0033 378.92 µM -2.02322013115755 0.0308241629527294 no 3245 0.0215252285238375 4636 280309
SGTC_3160 9100216 49.47 µM -2.02518879694662 0.0306895709837231 no 3246 0.0214239908014068 4690 17191039
SGTC_610 4215-0184 155 µM -2.04545993295497 0.0293317897959528 no 3247 0.0204047677345981 4699 5605015
SGTC_1507 4075-3230 155 µM -2.04913039773665 0.0290913527848483 no 3248 0.0202246828919651 4659 659771
SGTC_689 0833-0039 98 µM -2.05457983127302 0.0287374050282102 no 3249 0.019959802684278 4661 5374726
SGTC_959 1222-0044 107 µM -2.05505258533932 0.0287068685605802 no 3250 0.0199369629447454 4694 6083612
SGTC_2026 5148700 152 µM -2.05903707263922 0.0284505702612639 no 3251 0.0197453436017325 4699 79838
SGTC_1618 st003135 44.5 µM -2.06832091399817 0.027860775383127 no 3252 0.0193049282091204 4686 1270615
SGTC_2812 7970281 58.44 µM -2.07055161720267 0.0277205885432103 no 3253 0.0192003587980392 4697 2233435
SGTC_2765 myclobutanil 7.74 µM -2.07202418908299 0.0276283683657641 no 3254 0.019131592710846 4689 6336 Myclobutanil is a general use pesticide, and more specifically, a triazole fungicide registered for use on a wide range of food crops. Like other azoles, it acts by inhibiting fungal cytochrome P450 enzyme 14α-demethylase. YHR007C ERG11
SGTC_934 2950-0684 338 µM -2.0722176949279 0.0276162690451012 no 3255 0.0191225719688572 4688 1121253
SGTC_743 1275-0778 158 µM -2.07255595707554 0.0275951291697222 no 3256 0.0191068117482256 4687 2849257 YMR203W TOM40
SGTC_621 3584-0052 32.1 µM -2.07408396951859 0.0274998032268106 no 3257 0.0190357565463857 4723 2273927
SGTC_2648 atorvastatin 78.68 µM -2.08279090934903 0.0269618409099111 no 3258 0.0186351432847636 4720 60823 Atorvastatin is a specific inhibitor of HMG-CoA reductase. HMG-CoA reductase is the enzyme that catalyzes the conversion of HMG-CoA to mevalonate, an early step in cholesterol biosynthesis. YHR007C ERG11
SGTC_2109 5483026 200 µM -2.08371422744262 0.0269053119634537 no 3259 0.0185930846479676 4707 759335
SGTC_116 0155-0182 31.788 µM -2.08448913281901 0.0268579457888602 no 3260 0.0185578488493916 4593 771486
SGTC_545 4218-0007 221 µM -2.08460698561357 0.0268507481270549 no 3261 0.0185524949374106 4699 2840508
SGTC_200 k038-0079 37.545 µM -2.08695493493812 0.026707686381111 no 3262 0.0184461041777745 4716 3436683
SGTC_1975 st070967 30.8 µM -2.09551169129175 0.0261916955928349 no 3263 0.0180627651301454 4691 261391
SGTC_2606 farnesol 9.78 µM -2.09723106868251 0.0260890255890949 no 3264 0.0179865627326263 4675 445070 Farnesol is a polyprenyl alcohol found in plant essential oils. Induces apoptosis in cell cultures.
SGTC_73 0327-0325 16.231 µM -2.09866390534213 0.0260037232516349 no 3265 0.0179232693132119 4546 53298
SGTC_2164 5685496 200 µM -2.10322983004348 0.0257334508409833 no 3266 0.0177228419510333 4670 759046
SGTC_1941 st076221 61.8 µM -2.1076286891174 0.0254752952926819 no 3267 0.0175315599975367 4626 2828568
SGTC_2713 st079149 53.4 µM -2.11044259258972 0.0253112961096796 no 3268 0.0174101255158937 4716 3103253
SGTC_994 3910-0338 138 µM -2.11579035077058 0.0250020569121188 no 3269 0.0171813210667164 4716 3479481
SGTC_261 5-fluorouridine 15.376 µM -2.12384846707825 0.0245420751107639 no 3270 0.0168414083547345 4713 1821 5-fluorouridine (FUrd) is FDA-approved anticancer drug. As a 5-fluorauracil metabolite, FUrd is thought to also act by inhibiting thymidylate synthetase and through metabolism into cytotoxic ribonucleotides and deoxyribonucleotides that can be incorporated into DNA and RNA. In addition to being incorporated in DNA and RNA, the drug has been shown to inhibit the essential ribonuclease activity of the exosome complex.
SGTC_2602 kawain 100 µM -2.13807560768566 0.0237472863571773 no 3271 0.016255303645826 4683 5369129
SGTC_152 4469-0003 551.229 µM -2.14739370643319 0.0232385550820775 no 3272 0.0158809756363054 4696 697280
SGTC_3126 9127922 49.47 µM -2.16393582924186 0.0223580174158872 no 3273 0.0152346373334478 4661 45595682
SGTC_466 geldanamycin 89.2 µM -2.17625501989956 0.021720698180895 no 3274 0.0147680984408901 4746 5288382 HSP90 inhibitor.
SGTC_2916 7875993 68.79 µM -2.17956138951863 0.0215522827062226 no 3275 0.0146449947306932 4648 1299250
SGTC_2354 9060492 162 µM -2.19427560572378 0.0208161132624612 no 3276 0.0141078010364697 4719 6471895
SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 15.5 µM -2.19878847763304 0.0205946397511529 no 3277 0.0139464830926159 4728 2333 A French combination drug.
SGTC_824 1304-0008 100 µM -2.20202713973746 0.0204369323683512 no 3278 0.01383169572079 4734 768245
SGTC_3149 9097855 49.47 µM -2.20386761505123 0.0203477669147529 no 3279 0.0137668278413857 4697 25236625 YMR079W SEC14
SGTC_3270 9137563 49.47 µM -2.21522711683518 0.01980470108545 no 3280 0.0133722397587025 4731 17015724
SGTC_1012 4112-3522 18 µM -2.22840345625186 0.0191902359504978 no 3281 0.012926811414379 4726 3112398
SGTC_3020 9089140 49.47 µM -2.24202816789946 0.018571979799925 no 3282 0.0124797759329971 4732 17217859
SGTC_2959 9079155 11 µM -2.24759449067956 0.0183243173711772 no 3283 0.0123010296009949 4714 16189457
SGTC_285 1486-1325 46 µM -2.25073384881505 0.0181858828575047 no 3284 0.0122011997701585 4750 22310230
SGTC_3280 9140961 49.47 µM -2.25486558841934 0.0180050470949759 no 3285 0.0120708834289723 4733 4901226
SGTC_413 propylparaben 100 µM -2.25586344365456 0.0179616040752911 no 3286 0.0120395922793734 4722 7175 A pharmaceutical preservative.
SGTC_3314 9135860 59.4275 µM -2.26305969807557 0.0176509439798499 no 3287 0.0118160047472657 4716 25252478
SGTC_2156 5649887 115 µM -2.26535282551036 0.017552918757826 no 3288 0.0117455183862831 4751 54680440 YKL052C | YBR257W ASK1 | POP4
SGTC_3278 9139605 49.47 µM -2.26805922151576 0.0174378256116527 no 3289 0.0116627986872289 4710 7958859
SGTC_1004 4084-0029 199 µM -2.27198925180127 0.0172718433876742 no 3290 0.0115435797593432 4731 716894 YLR208W SEC13
SGTC_316 k060-0003 58.6 µM -2.27691046669364 0.0170659039315715 no 3291 0.0113957863663591 4757 6152314
SGTC_2597 laccaic acid a 100 µM -2.29324862167621 0.0163971803998741 no 3292 0.0109168476704672 4702 5491415 A textile dye.
SGTC_1654 st012436 41.8 µM -2.29522006446778 0.0163180265271319 no 3293 0.0108602579426195 4754 4323132
SGTC_1859 st055998 20 µM -2.29953903457279 0.016145761975743 no 3294 0.0107371747307798 4697 676301
SGTC_94 0334-0113 514.748 µM -2.30059130818164 0.0161040282991078 no 3295 0.0107073713983909 4738 6795178
SGTC_2330 7979373 200 µM -2.31154232211154 0.0156751649877428 no 3296 0.010401459149631 4692 1863007
SGTC_453 enantio-paf c16 10 µM -2.31369830663248 0.0155918968485438 no 3297 0.0103421384268165 4294 13871343 A lipid and platelet activating factor
SGTC_2025 5147754 141 µM -2.32094524813149 0.0153147829676977 no 3298 0.0101448995205683 4734 315777 YLR208W SEC13
SGTC_2549 cedrol 20.94 µM -2.32455685663772 0.0151782660128707 no 3299 0.0100478340066711 4730 6708665 A sedative which affects the nervous system.
SGTC_2750 bromebric acid 70.15 µM -2.3361177248777 0.0147482783617606 no 3300 0.00974255337980208 4732 5358572 An antineoplastic and ion channel blocker. YOR256C TRE2
SGTC_1430 4049-0248 69.1 µM -2.36116319485125 0.0138525607665826 no 3301 0.00910885586087715 4757 22774488
SGTC_1516 st013856 110 µM -2.36165888758965 0.0138353171445932 no 3302 0.00909668692193831 4741 5281404 A mutagen and neurotoxin.
SGTC_1989 st071868 50.2 µM -2.36386998705963 0.0137586250777789 no 3303 0.00904257905036488 4746 16414057
SGTC_2541 muurolladie-3-one 83.07 µM -2.3667925951537 0.0136578172084297 no 3304 0.00897149245952399 4722 3989419 Muurolladie-3-one is a natural monoterpene ketone which is a component of some essential oils. YMR203W TOM40
SGTC_2760 etidronate 98.04 µM -2.40011757119257 0.0125526848692585 no 3305 0.00819490334440468 4719 3305 A chelator and antioxidant.
SGTC_832 4083-0019 164 µM -2.40031704242512 0.0125463101923644 no 3306 0.0081904386090435 4769 1990758
SGTC_2825 7998094 58.44 µM -2.40747281764457 0.0123194730059359 no 3307 0.00803167898216644 4715 2987815
SGTC_403 arphamenine a 50 µM -2.42502666056107 0.0117780110173285 no 3308 0.00765363129001497 4762 5487158 An arginine aminopeptidase inhibitor.
SGTC_1714 st033236 13.627 µM -2.429668267536 0.0116383364278608 no 3309 0.00755632399909623 4742 2916566
SGTC_85 0868-0259 160.055 µM -2.43490061642629 0.0114826116171294 no 3310 0.00744794017582073 4746 83173
SGTC_2777 climbazole 1.536 µM -2.44825187694068 0.0110934279374362 no 3311 0.00717756322185392 4574 37907 Climbazole, an imidazole, is topically used antifungal; inhibits lanosterol 14α-demethylase, preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YLR127C APC2
SGTC_165 k038-0023 64.381 µM -2.44862404245739 0.0110827458443262 no 3312 0.00717015214341471 4732 46368543
SGTC_134 0269-0018 6.916 µM -2.45309206928759 0.0109551989053186 no 3313 0.00708170410955723 4728 4378915
SGTC_3195 9113082 49.47 µM -2.46814703446722 0.0105347865494448 no 3314 0.00679072599998796 4730 17018038
SGTC_2297 7971671 152.32 µM -2.47345985659189 0.0103898176018193 no 3315 0.00669059182025091 4732 909016
SGTC_941 3237-0776 460 µM -2.51338492436127 0.00935495789659683 no 3316 0.00597893914066694 4753 760008
SGTC_2336 9001819 198.65 µM -2.52908481892334 0.00897341259825532 no 3317 0.00571801933137724 4734 2989602
SGTC_2074 5212007 75.395 µM -2.54997972600433 0.0084867982391701 no 3318 0.00538645918216029 4754 758611
SGTC_395 anisomycin 6.25 µM -2.5589405477776 0.00828531035092629 no 3319 0.00524958476060662 4771 6610309 Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.
SGTC_683 panaxydol 45 µM -2.56562373756088 0.00813778305351306 no 3320 0.00514952400078466 4762 5283280 Panoxydol generates reactive oxygen species (ROS); known to Induce apoptosis.
SGTC_1509 1326-1131 80 µM -2.5761714713483 0.00790964301201328 no 3321 0.00499505452135319 4755 768313
SGTC_1068 loratadine 26.9 µM -2.60615132110093 0.00729163141213309 no 3322 0.00457829994265777 4779 3957 A H1 histamine antagonist.
SGTC_1091 telmisartan 47.6 µM -2.63225556822023 0.00678860072244027 no 3323 0.00424100160720381 4775 65999 Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
SGTC_833 3852-0053 558 µM -2.6403388566789 0.00663917873624568 no 3324 0.00414115848006698 4781 3123681
SGTC_2795 7780010 54.55 µM -2.64141487743031 0.00661950905677326 no 3325 0.00412802753756887 4748 953673
SGTC_1250 0485-0349 40.2 µM -2.65194517633518 0.00642971770832977 no 3326 0.00400147676151196 4743 6842794 YDL195W SEC31
SGTC_2158 5657123 3.6195 µM -2.66008242270519 0.00628637141601487 no 3327 0.00390607656514092 4783 2858827
SGTC_3128 9127691 49.47 µM -2.67224400416835 0.00607740561721359 no 3328 0.00376729195393108 4771 41316314
SGTC_507 nimesulide 162 µM -2.69588665433218 0.00568871027331143 no 3329 0.00351007750140978 4775 4495 A COX2 inhibitor.
SGTC_321 4534-3890 65.3 µM -2.73332712848751 0.00511821518848838 no 3330 0.0031349013234439 4790 699746
SGTC_1514 1189-1591 158 µM -2.73335230591189 0.00511784934147019 no 3331 0.00313466167057989 4773 767698 YMR146C TIF34
SGTC_2334 9017922 200 µM -2.75561451201694 0.00480332944943311 no 3332 0.00292909971284792 4766 3163164
SGTC_315 k915-0449 187 µM -2.78284012244301 0.00444218585715011 no 3333 0.00269426760818545 4792 20970215 YNL149C PGA2
SGTC_182 3448-4371 550.524 µM -2.83039316789689 0.00386919830181225 no 3334 0.00232454172134555 4756 3491403
SGTC_361 000s-0510 1.45 µM -2.85991495200233 0.00354770776052141 no 3335 0.00211877317260644 4742 660
SGTC_211 3455-0679 143.504 µM -2.97978645409458 0.00247464444564241 no 3336 0.00144224696150186 4743 748649
SGTC_1010 4112-3296 15.2 µM -2.98368439996998 0.00244530116689588 no 3337 0.00142400182815363 4797 704384
SGTC_2625 euphol 100 µM -3.03254515074596 0.00210326713464668 no 3338 0.00121250408290732 4774 6708538 A triterpene alcohol.
SGTC_3018 9082602 49.47 µM -3.16544938207102 0.00138100230069426 no 3339 0.000774218003461964 4731 17332089
SGTC_435 c-PAF 6.7 µM -3.16926096108754 0.00136412136568598 no 3340 0.00076413555269112 4754 124663 C-PAF (Carbamyl-Platelet-Activating-Factor) is a non-hydrolyzable bioactive analog of PAF used a chemical tool to determine the biological processes of PAF including stimulating human neutrophils and cause cultured retinal endothelial cell death in rats. Stimulates neutrophil degranulation responses, but resists metabolic inactivation by acetylhydrolase
SGTC_2999 9069765 71.4286 µM -3.17179240805894 0.00135301435976795 no 3341 0.00075750631049313 4778 2097066
SGTC_3039 9090270 49.47 µM -3.21816555723787 0.00116363253888244 no 3342 0.000645066638357895 4796 17173750
SGTC_2858 9025781 8.96 µM -3.30764272836492 0.000865123360329855 yes 3343 0.000470423773543764 4728 4894980 YPL153C RAD53
SGTC_3219 9131112 49.47 µM -3.33907944280802 0.00077821862044592 yes 3344 0.000420282609068544 4753 17612988 YMR079W SEC14
SGTC_3215 9129942 49.47 µM -3.36666983006918 0.00070864771449049 yes 3345 0.000380408595623093 4789 17682944
SGTC_3214 9129694 49.47 µM -3.36677391463942 0.000708396475785378 yes 3346 0.000380265055814067 4791 17158655
SGTC_2778 tioconazole 65.09 nM -3.45491164826716 0.00052280595895637 yes 3347 0.000275236588963643 4758 5482 Tioconazole is a topically used antifungal; acts by inhibiting lanosterol 14α-demethylase, thereby preventing the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane. YGL116W CDC20
SGTC_2766 oltipraz 83.91 µM -3.53047328954059 0.000400673915868537 yes 3348 0.000207408448649188 4805 47318 Oltipraz is an antischistosomiasis drug found to inhibit carcinogenesis. Its mechanism of action is believed to be the induction of phase II detoxifying enzymes resulting in diminished carcinogen-DNA binding. YMR203W TOM40
SGTC_3038 9091290 49.47 µM -3.53832385320951 0.000389633774847382 yes 3349 0.000201337924451597 4796 25236843
SGTC_3034 9090421 49.47 µM -3.5583204447439 0.000362775663500425 yes 3350 0.000186616900920489 4787 17173761
SGTC_2567 aureobasidin a 60 nM -3.77950149102125 0.000160685679974828 yes 3351 7.85713262204699e-05 4794 9963430 Aureobasidium a is a potent inhibitor of inositol phosphorylceramide (IPC) synthase in fungi. YKL004W | YMR211W | YDR367W AUR1 | DML1 | KEI1
SGTC_1881 5652484 16 µM -4.00966425429431 6.56594300203257e-05 yes 3352 3.04025719188381e-05 4806 2255129
SGTC_3042 9091578 49.47 µM -4.10681588859517 4.43492534862773e-05 yes 3353 2.00575362562477e-05 4779 25236497
SGTC_1251 0490-5699 265 µM -4.71134183506469 3.17185982082346e-06 yes 3354 1.23045525339329e-06 4810 3883818
SGTC_3026 9090633 49.47 µM -5.20402847323216 2.87360794649516e-07 yes 3355 9.75070535938159e-08 4810 25236842